Miracle-dz/UniFAR-FTUs huggingface dataset:
Three-Dimensional Modeling of Thyroid Hormone Metabolites Binding to the Cancer-Relevant αvβ3 Integrin: In-Silico Based Study

Background Thyroid hormones (TH), T4 and T3, mediate pro-mitogenic effects in cancer cells through binding the membrane receptor αvβ3 integrin. The deaminated analogue tetrac effectively blocks TH binding to this receptor and prevents their action. While computational data on TH binding to the αvβ3 integrin was published, a comprehensive analysis of additional TH metabolites is lacking. Methods In-silico docking of 26 TH metabolites, including the biologically active thyroid hormones (T3 and T4) and an array of sulfated, deiodinated, deaminated or decarboxylated metabolites, to the αvβ3 receptor binding pocket was performed using DOCK6, based on the three-dimensional representation of the crystallographic structure of the integrin. As the TH binding site upon the integrin is at close proximity to the well-defined RGD binding site, linear and cyclic RGD were included as a reference. Binding energy was calculated for each receptor-ligand complex using Grid score and Amber score with distance movable region protocol. Results All TH molecules demonstrated negative free energy, suggesting affinity to the αvβ3 integrin. Notably, based on both Grid and Amber scores sulfated forms of 3,3’ T2 (3,3’ T2S) and T4 (T4S) demonstrated the highest binding affinity to the integrin, compared to both cyclic RGD and an array of examined TH metabolites. The major thyroid hormones, T3 and T4, showed high affinity to the integrin, which was superior to that of linear RGD. For all hormone metabolites, decarboxylation led to decreased affinity. This corresponds with the observation that the carboxylic group mediates binding to the integrin pocket via divalent cations at the metal-ion-dependent adhesion (MIDAS) motif site. A similar reduced affinity was documented for deaminated forms of T3 (triac) and T4 (tetrac). Lastly, the reverse forms of T3, T3S, and T3AM showed higher Amber scores relative to their native form, indicating that iodination at position 5 is associated with increased binding affinity compared to position 5’. Summary Three-dimensional docking of various TH metabolites uncovered a structural basis for a differential computational free energy to the αvβ3 integrin. These findings may suggest that naturally occurring endogenous TH metabolites may impact integrin-mediate intracellular pathways in physiology and cancer.
A Meta-Analysis of Emotional Evidence for the Biophilia Hypothesis and Implications for Biophilic Design

The biophilia hypothesis posits an innate biological and genetic connection between human and nature, including an emotional dimension to this connection. Biophilic design builds on this hypothesis in an attempt to design human-nature connections into the built environment. This article builds on this theoretical framework through a meta-analysis of experimental studies on the emotional impacts of human exposure to natural and urban environments. A total of 49 studies were identified, with a combined sample size of 3,201 participants. The primary findings indicated that exposure to natural environments had a medium to large effect on both increasing positive affect and decreasing negative affect. This finding supported the anticipated emotional dimension of the biophilia hypothesis and lends credibility to biophilic design theory. Evidence was revealed in support of the affective/arousal response model. Immersion in environments indicated a larger effect size than laboratory simulation of environments. Methodological recommendations for future experimental research were few, however the Positive and Negative Affect Schedule (PANAS) outcome measure was recommended as a measure of both positive and negative affect for further studies. A combination measurement of stress related outcome variables was proposed to further explore the affective/arousal response model and its potential relationship to the biophilia hypothesis. The meta-analysis provides evidence for fundamental theories regarding human-nature connection, while revealing gaps in current knowledge.
Simultaneous energy harvesting and information processing in wireless multiple relays with multiple antennas

ABSTRACT Wireless networks suffer from battery discharging specially in cooperative communications when multiple relays have an important role but they are energy constrained. To overcome this problem, energy harvesting from radio frequency signals is applied to charge the node battery. These intermediate nodes have the ability to harvest energy from the source signal and use the energy harvested to transmit information to the destination. In fact, the node tries to harvest energy and then transmit the data to destination. Division of energy harvesting and data transmission can be done in two algorithms: time-switching-based relaying protocol and power-splitting-based relaying protocol. These two algorithms also can be applied in delay-limited and delay-tolerant transmission systems. The previous works have assumed a single relay for energy harvesting, but in this article, the proposed method is concentrated on improving the outage probability and throughput by using multiple antennas in each relay node instead of using single antenna. According to our simulation results, when using multi-antenna relays, ability of energy harvesting is increased and thus system performance will be improved to great extent. Maximum ratio combining scheme has been used when the destination chooses the best signal of relays and antennas satisfying the required signal-to-noise ratio.
Timing Analysis of TSN-Enabled OPC UA PubSub

Industrial automation is changing towards a flat and highly interconnected architecture, with requirements for end-to-end real-time enabled machine-to-machine communications. Technologies such as time-sensitive networking (TSN) and OPC Unified Architecture (OPC UA) publish-subscribe provide the necessary features. While TSN is well explored, OPC UA's execution time behavior remains unknown. This article presents findings made while extending the open62541 OPC UA Pub Sub stack with the 802.1q VLAN tag to enable IEEE 802.1Qbv time-aware scheduling. The results include end-to-end timing measures and worst-case execution time analyses considering various payloads. Time-predictable T-CREST platforms host the publisher and subscriber, and a TSN network handles message transmission. The paper concludes by outlining further research focusing on dynamic memory access, buffer management, and the inclusion of non-priority access to the Ethernet port.
Intelligent Brain Tumor Detection System using Deep Learning Technique

Brain tumors are dangerous and serious disorders affected by uncontrolled cell growth in the brain. Brain tumors are one of the most challenging diseases to cure among the different ailments encountered in medical study. Tumors are classified as either benign or malignant, with benign tumors being non-cancerous and malignant tumors being cancerous from the MRI (Magnetic Resonance Images). There are several tumor detection techniques available, but more study is needed in this field since numerical analysis, precisedisorder diagnosis, and brain tumor detection are all necessary for scientific confirmation. As a result, good planning can protect a person's life that has a brain tumor. Using the 2D Convolutional Neural Network (CNN) technique, this study proposes Computer-Aided Diagnosis (CAD) a deep learning-based intelligent brain tumor detection framework for categorization of brain MRI images with the dataset from Figshare, It is a combination of 3064 brain MRI images from 233 patients into two categories: benign and malignant. The performance of the proposed framework is calculated and compared with state-of-the-art methods in terms of accuracy, recall, and F1-Score.
Semi Autonomous Detection of Bite Points for a Surgical Needle

In this paper, a semi-autonomous solution has been proposed where bite points or entry and exit points were calculated around a wounded region for the purpose of suturing. These bite points were calculated on either side of the wound at a distance of at least 3 mm from the center of the wound along its length. A user-friendly interface that has been provided can help assist the medical staff to manually perform segmentation of the wound and generate the optimal best-fit curve which are the prerequisites to the calculation of bite points. The final results obtained were validated on a scale of 0 to 10 by doctors who have had an average of 25 years of practice in the medical field. A score of 7.89 was obtained for the above-mentioned algorithm.
Traffic Steering in Edge Compute Devices using eXpress Data Path for 5G and TSN Integration

Timeliness has become critical across industrial automation, AR/VR, robotics, and many other use cases. IEEE Time-sensitive networking (TSN) standards provide high-reliability & determinism across wired (Ethernet) networks. Time-critical hard/soft real-time applications typically run over these wired TSN links. However, TSN over-wired links lack the mobility and potential to meet all the needs of Industry 4.0. New generation wireless technologies such as Wi-Fi and 5G that are now introducing TSN supporting capabilities can fulfill this need. The 5G Release 16 from the 3rd Generation Partnership Project (3GPP) supports Ultra-Reliable Low-Latency Communications (URLLC), which brings the possibility of combining 5G with TSN to meet the stringent requirements of industry 4.0. 5G that comes with the support of both private and public networks is coupled with TSN to support the use cases with deterministic performance and required latency levels. The 5G-TSN networks must provide a low end-to-end (E2E) latency to support time-sensitive applications. The traffic steering delay within the User Equipment (UE) in edge compute devices is a critical component in addition to network latencies. This paper discusses the traffic steering aspects of UE and proposes a new use case of eXpress Data Path (XDP) programming over the 5G modem of UE to efficiently steer the traffic in 5G-TSN networks. Experiment results show that the proposed solution provides 100 times lower latency in traffic steering latency compared to a conventional Layer 2 (L2) software bridge.
Aizerman Conjectures for a Class of Multivariate Positive Systems

The Aizerman conjecture predicts stability for a class of nonlinear control systems on the basis of linear system stability analysis. The conjecture is known to be false in general. Here, a number of Aizerman conjectures are shown to be true for a class of internally positive multivariate systems, under a natural generalization of the classical sector condition and, moreover, guarantee positivity in closed loop. These results are stronger and/or more general than existing results. This article relates the obtained results to other, diverse, results in the literature.
Investigating the Factors Affecting Job Satisfaction and Turnover:Case of Sultan Qaboos University

Job satisfaction has received wide attention as one of the core elements of an organization that is successful in achieving its purposes. This study aims to investigate the job satisfaction of Sultan Qaboos University (SQU) administrative staff by measuring the job satisfaction level of non-academic staff. The study is concerned with the problem of turnover amongst administrative employees in 2014 which was believed to be high by Majlis AlShura (Oman Parliament), this drove the university to create an incentive program through increasing salaries. This is a descriptive quantitative cross sectional applied research where data were collected by using a structured questionnaire consisting of 42 items covering seven domains of job satisfaction. The overall response rate (150 completed questionnaire) was 68%, 137 (47.4% males, 52.6% females) were usable. The outcome showed that administrative staffs were satisfied with their job. It also revealed that job satisfaction was affected by staff’s gender, where males showed higher job satisfaction than females. It also showed that those who have shorter experience are more satisfied than those who have longer experience and those who hold lower qualifications and lower job levels have higher job satisfaction compared to those who have higher qualifications and job level.
Optimal investment in a market with borrowing and unbounded random coefficients

We consider the problem of optimal investment in a market with borrowing and random coefficients. We assume that the bond interest rate, the borrowing interest rate, the appreciation rate and the volatility of stock, are random and possibly unbounded. Due to the possibility of borrowing, the formulated optimal investment problem is an optimal stochastic control problem with nonlinear system dynamics and possibly unbounded coefficients. Explicit closed-form solutions in terms of a linear backward stochastic differential equation are obtained for the power and logarithmic utility from terminal wealth. The optimal controls turn out to be of a linear state-feedback form.
The Effect of Figs and Orange Albedo Addition on the Quality Properties of “İncir Uyutması ”, A Traditional Dairy Dessert

: In this research, “ incir uyutması ”, a local dairy dessert, was produced by adding figs (10%, 15% and 20%) and orange peel albedo (0.2%, 0.4% and 0.6%) layer at different ratios. Produced dairy desserts were stored at 4ºC for 7 days. As a result of the physicochemical analysis, it was determined that dry matter, viscosity, a* (redness)
AN ABSTRACT OF THE THESIS OF Redacted for Privacy

This paper presents a model of the determination of excise tax rates by studying the substantial variation in the state excise taxes in the U. S. brewing industry. Two approaches are used. First, assuming that the government is only interested in the public interest, a socially optimal tax rate is derived. The magnitude of the tax rate is determined by the negative externalities of drinking behavior imposed on nondrinkers. Second, a special interest group that engages in lobbying activity and makes campaign contributions is introduced into the model. The government not only cares about the welfare of the society, but is also concerned about the abundance of its campaign contributions. The lobbying activity by the interest group causes the tax rate to deviate from the social optimum. Data from the beer industry in 1992 and 1995 are employed in the estimation. Instrumental variable techniques are used to deal with endogenous consumption and heteroscedasticity. The estimation indicates that states with a production capacity one barrel per person higher than the average state will have a beer tax 20 cents per barrel lower than average. The paper provides evidence that the power of interest group hampers the economic efficiency of the local tax system.
IMPACT OF RURAL SETTLEMENTS ON THE DEFORESTATION OF THE AMAZON

In recent years, it is possible to realize a change in the profile of deforestation in the Amazon, reflecting increasing rates of “little deforestations”, result from the diversification of productive activities related to family farming. In the Amazon, the state of Pará stands out for its strategic location when considering the Arc of Deforestation in advance, and also for its contribution in the distribution of lands by the Agrarian Reform, whose settlements add 1.055 units and 221.04 families installed. In this context, this paper aims to investigate the influence of the settlement projects of agrarian reform have on deforestation in the city of Novo Repartimento (PA) from 2000 to 2013.
The Effects of Low Temperature and Colchicine on Chromosome Structure in Urodele Developmental Stages I. A comparison of euchromatic and hetero chromatic condensation patterns

Chromosome of Trillium and certain other species of plants have demonstrated less intense reaction of the heterochromatin to the Feulgen staining procedure than does the euchromatin when maintained at tempera tures below 5•Ž (Darlington and LaCour 1941, Dyer 1963). This reaction of the heterochromatic DNA to low temperature has been demonstrated in a few urodele organisms, including Triton and Ambystoma (Callan 1941, Dyer 1963, Callan 1966). The temperature dependent heterochromatic reaction was originally interpreted as representing DNA deficiency in the Feulgen negative areas (Darlington and LaCour 1941). Recently this conclusion has been challenged through studies with autoradiography and microspectrophoto metry; through these techniques it has been suggested that the Feulgen negative areas of the chromosomes are under spiralized areas rather than deficient in DNA (Woodard and Swift 1965, Woodard et al. 1966). This investigation was initiated to evaluate the low temperature reaction of chromosomes in premetamorphic stages of urodele development. Evalua tions were made of condensation patterns for euchromatin and heterochromatin following low temperature and colchicine exposure.
Surveillance of the Microbial Quality of Soybean Products Sold within Markets in Port Harcourt Metropolis, Rivers State, Nigeria

Considerable public health burden and challenge has been caused by foodborne pathogens. They cause illnesses to children, elderly and immune-compromised persons and this poses a great health risk. The microbial quality of locally and industrially soybean products sold within in Port Harcourt Metropolis, Nigeria was investigated. The results show significant higher bacteria and fungi counts [p < 0.05] in locally prepared samples compared to industrially prepared samples. Occurrences of the bacteria isolated from industrial samples include: Pseudomonas sp. [37.5%], Bacillus sp. , Staphylococcus sp. [25% each] and Streptococcus sp. [12%], while Pseudomonas sp. and Staphylococcus sp. were the most frequent bacteria in locally processed samples [25% each]. Fungi isolated from industrially processed samples include: Rhizopus sp. , Aspergillus sp. and Saccharomyces sp. [33.3% each]. The most frequent fungus in locally produced samples is Rhizopus sp. [40%] followed by Saccharomyces sp. and Aspergillus sp. [30% each]. 50% of the isolates were resistant to ampicillin and ofloxacin, while about 70% were sensitive to erythromycin and augmentin. The results revealed that locally made soy products would most likely cause food-borne illnesses, stressing the need for local vendors to be enlightened on the practice of good hygiene and observing Hazard analysis and critical control points during processing and packaging of these products for consumption. Most of the isolates are spoilage microorganisms but several of them invaded the product through poor handling and processing routes employed.
Size-dependent free vibration analysis of functionally graded piezoelectric plate subjected to thermo-electro-mechanical loading

Analytical solutions are presented to study the thermo-electro-mechanical vibration problem of functionally graded piezoelectric materials’ nanoscale rectangular plates based on the size-dependent Kirchhoff plate theory. The plate is under an applied electric voltage, a biaxial force, and a uniform temperature rise. The material properties vary continuously along the thickness direction. To check the validity of the method, the results are compared with the results obtained in previous studies for the special cases. Finally, a parametric study is accompanied to survey the effects of the gradient index, length scale parameter, length-to-thickness ratio, external electric, and temperature change on the vibration of functionally graded piezoelectric nanoplates.
The Role of Systemic Inflammatory Markers in the Diagnosis of Hyperemesis Gravidarum

Öz This study was aimed to investigate the diagnostic value of the neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), platelet distribution width (PDW), mean platelet volume (MPV), plateletcrit (PCT) and red cell distribution width (RDW) in patients with hyperemesis gravidarum (HG). We conducted this retrospective study in a tertiary center between August and December 2019.A total of 72 pregnant patients with HG and 78 pregnant women without nausea and vomiting were included in the study. Hemoglobin (Hb), white blood cell count (WBC), neutrophil count, lymphocyte count, platelet count, RDW, PDW, MPV, PCT, and CRP values were all derived from patients' medical files. The student's t-test was used to compare the normally distributed data. Mann-Whitney U test was used to compare the non-normally distributed data. The median NLR value of the HG group was 3.4 (1.1-7.2), and the control group was 1.98 (1.0-4.6). This difference was statistically significant (p<0.05). The median PLR value of the HG group (152.6 [69.8-338.1]) was significantly higher (p<0.05) than the PLR value of the control group (88.1 [48.3-201.2]). The results of this study suggest that NLR and PLR can be used as effective markers in the diagnosis of HG. The increased values of NLR and PLR also indicate that inflammation may act a crucial role in the pathogenesis of HG.
Spleen stiffness-spleen size-to-platelet ratio risk score as noninvasive predictors of esophageal varices in patients with hepatitis B virus-related cirrhosis

Abstract This study was conducted to evaluate the predictive value of spleen stiffness-spleen size-to-platelet ratio risk score (SSPS) as a noninvasive predictor of esophageal varices (EVs) and to compare it with others. In this retrospective study, from April 2017 to October 2018, a total of 65 patients with hepatitis B virus-related cirrhosis who underwent the liver and spleen stiffness (LS, and SS) measurements by 2 dimensional-shear wave elastography and endoscopic evaluation for EVs were enrolled. Liver stiffness-spleen size-to-platelet ratio risk score (LSPS) and SSPS were calculated. The prognostic values were assessed by the area under the receiver operating characteristic curve (AUC). Twenty-six patients had no EV on endoscopy. Among 39 patients who had EVs, 12 patients had high risk EVs. The AUCs of the LS value, SS value, LSPS, and SSPS for predicting EVs were 0.72, 0.77, 0.80, and 0.85, respectively. The AUCs of the LS value, SS value, LSPS, and SSPS for predicting high-risk EVs were 0.55, 0.78, 0.67, and 0.80, respectively. SSPS had the highest specificity, at 96.15%, for predicting EVs. SSPS may be beneficial to exclude from having EVs and it is expected that the frequency of performing endoscopies for screening EVs can be reduced.
The haplotypes GCA and ACA in ESR1 gene are associated with the susceptibility of recurrent spontaneous abortion (RSA) in Chinese Han

Abstract The nonstructured abstract were supplied as following: Estrogen receptor is involved in the pathogenesis of recurrent spontaneous abortion (RSA). The ESR1 and ESR2 genes can mediate nongenomic estrogen responses. This study aimed to assess the genetic association between the ESR1 and ESR2 genes polymorphisms and RSA susceptibility in a Chinese Han population. A total of 258 women who had experienced RSA and 264 unrelated healthy women were recruited. Genotypes of the 6 polymorphisms in the ESR1 (rs9340799, rs2234693, and rs3798759) and ESR2 genes (rs207764, rs4986938, and rs1256049) were analyzed using Snapshot technology. No association was detected between the alleles and genotypes of ESR1 rs9340799, rs2234693, and rs3798759 polymorphims and RSA risk (P > .05). Subjects carrying the haplotype of rs9340799A-rs2234693C-rs3798759A had a significantly increased RSA risk in the case group compared with the control group (P = .0005, Padj = .003, odds ratios [95% CI] = 0.35 [0.19–0.65]). However, subjects carrying the haplotype of rs9340799G-rs2234693C-rs3798759A had a significantly decreased RSA risk in the case group compared with the control group (P = .0005, Padj = .003, odds ratios [95% CI] = 2.99 [1.57–5.70]). In addition, no association was found between the alleles, genotypes, and haplotypes of ESR2 rs207764, rs4986938, rs1256049 polymorphisms and RSA risk (P > .05). In conclusion, the haplotype rs9340799A-rs2234693C-rs3798759A of ESR1 might be a risk factor. And the haplotype rs9340799G-rs2234693C-rs3798759A of ESR1 might be a protective factor for RSA in a Chinese Han population.