Miracle-dz/UniFAR-FTUs huggingface dataset:
Experimental trap fishery for the crabs Platyxanthus patagonicus and Ovalipes trimaculatus in the San Matías Gulf, Patagonia, Argentina

Crab species had not been exploited until recently in the San Matías Gulf. An experimental trap fishery plan was developed to provide information on the feasibility of their potential extraction. Sampling was carried out using an artisanal shellfish boat in the San Matías Gulf. Nine baited traps, three of each type (cubical, tubular-conical and tubular-pyramidal) were intercalated along a master line. The total number of crabs of each species caught was compared among lines (N=27), types of trap and soaking times (6, 24 and 48 h). A total of 137 traps of 243 traps employed caught crabs. More crabs were caught in the cubical traps than in the other types. Comparisons of numbers of crabs among lines allowed identification of areas having different relative abundances, with an average of 3.56 crabs per trap. The catch of Ovalipes trimaculatus was significantly greater in lines on the 10-m isobath. Two lines, on the 50-m isobath, showed the best results for Platyxanthus patagonicus. The total number of crabs per trap obtained during a soaking time of 6 h was significantly less than the number caught with longer soaking times. Only individuals exceeding 50 mm in carapace width were caught. The size-frequency distributions differed significantly between sexes for the two species, with males larger than females. In O. trimaculatus, males made up 29% of the catch and the remainder was constituted of non-ovigerous females; mean carapace width was 92.93 mm for females and 105.93 mm for males. Forty per cent of P. patagonicus were males (mean carapace width: 99.33 mm). Females bearing eggs amounted to 45% of the total females. Females' mean carapace width was 90.58 mm. Based on the results obtained, preliminary suggestions for management of a potential fishery for these species are made within a precautionary approach.
Adenosine A2A Receptor Antagonists Affects NMDA Glutamate Receptor Function. Potential to Address Neurodegeneration in Alzheimer’s Disease

(1) Background. N-methyl d-aspartate (NMDA) ionotropic glutamate receptor (NMDAR), which is one of the main targets to combat Alzheimer’s disease (AD), is expressed in both neurons and glial cells. The aim of this paper was to assess whether the adenosine A2A receptor (A2AR), which is a target in neurodegeneration, may affect NMDAR functionality. (2) Methods. Immuno-histo/cytochemical, biophysical, biochemical and signaling assays were performed in a heterologous cell expression system and in primary cultures of neurons and microglia (resting and activated) from control and the APPSw,Ind transgenic mice. (3) Results. On the one hand, NMDA and A2A receptors were able to physically interact forming complexes, mainly in microglia. Furthermore, the amount of complexes was markedly enhanced in activated microglia. On the other hand, the interaction resulted in a novel functional entity that displayed a cross-antagonism, that could be useful to prevent the exacerbation of NMDAR function by using A2AR antagonists. Interestingly, the amount of complexes was markedly higher in the hippocampal cells from the APPSw,Ind than from the control mice. In neurons, the number of complexes was lesser, probably due to NMDAR not interacting with the A2AR. However, the activation of the A2AR receptors resulted in higher NMDAR functionality in neurons, probably by indirect mechanisms. (4) Conclusions. A2AR antagonists such as istradefylline, which is already approved for Parkinson’s disease (Nouriast® in Japan and Nourianz® in the US), have potential to afford neuroprotection in AD in a synergistic-like fashion. i.e., via both neurons and microglia.
Variation in the Vulnerability of Prey to Different Predators: Community-Level Consequences

Midge larvae (Diptera, Chironomidae) that weave filamentous algae into retreats of tufts, are dominant primary consumers in a river food web. In a previous study, densities of tuft—weaving midges increased in the presence of large fish. In the absence of large fish, midges decreased as densities of predatory invertebrates built up, and higher standing crops of algae were maintained. To examine the mechanisms underlying these dynamics, we compared the vulnerability of tuft—weaving midges (naked or in algal tufts) to fish and predatory invertebrates, in field and laboratory experiments. When midges were exposed for 1 h in the river to fish, 15 out of 15 midges in tufts survived, while 15 of 15 naked midges were consumed. Tufts afforded only partial protection to midges exposed to invertebrate predators, however. After 1 h, enhancement of survivorship by tufts was moderately significant for midges exposed to aeshnids, and insignificant for midges exposed to lestids and naucorids. We suggest that the vulnerab.
Impact of fascia iliaca block on pain, opioid consumption, and ambulation for patients with hip fractures - a prospective, randomized study.

OBJECTIVES To determine the effect of the fascia iliaca block (FIB) on patients undergoing surgery for hip fractures. DESIGN Prospective, randomized controlled trial SETTING:: Level I trauma center. PATIENTS/PARTICIPANTS Patients (N = 97) undergoing surgery for hip fractures were prospectively randomized to receive either a perioperative FIB (FIB group) or receive no block (control group) from February 2018 to April 2019. MAIN OUTCOME MEASURES visual analog score (VAS), morphine milligram equivalents (MME), post-operative ambulatory distance RESULTS:: Fifty-seven patients were randomized to the FIB group and 40 patients were randomized to the control group. Eighteen patients crossed over from the FIB to the control group, and twelve crossed from the control to the FIB group. In the intent to treat analysis, demographic data, mechanism of injury, radiographic fracture classification, and surgical procedure were similar between the two groups. The FIB group consumed fewer MMEs prior to surgery (13 versus 17, p = 0.04), had a trend toward improved VAS on postop day (POD) 2 (0 versus 2 p = 0.06), and walked a farther distance POD 2 (25' versus 2 ' p = 0.09). A greater proportion of the FIB group was discharged home (50.9% versus 32.5%, p = 0.05). There were no differences in opioid-related, block-related, or medical complications between groups. In the as treated and per protocol analyses there were no significant differences. CONCLUSIONS A single perioperative FIB for patients with hip fractures undergoing surgery may decrease opioid consumption and increase the likelihood that a patient is discharged home. LEVEL OF EVIDENCE Level II, Therapeutic.
Evidence Relating to Environmental Noise Exposure and Annoyance, Sleep Disturbance, Cardio-Vascular and Metabolic Health Outcomes in the Context of IGCB (N): A Scoping Review of New Evidence

WHO published the Environmental Noise Guidelines for the European Region in 2018, based on seven systematic reviews including studies published between 2000 and 2014. Since then, new studies were published. At the request of the UK Department for Environment, Food and Rural Affairs (DEFRA), a review on annoyance, sleep disturbance, cardiovascular and metabolic effects in relation to environmental noise was prepared. The aim was to advise the Interdepartmental Group on Costs and Benefits Noise Subject Group (IGCB(N)) whether this new evidence warrants an update of their recommendations. Four databases for observational studies were screened and data were extracted on design, type and measurements of exposures and outcomes and confounders and their associations. The quality of the studies was indirectly assessed for cardiovascular and metabolic effects by only including studies with a case control or cohort design. For studies on annoyance and sleep disturbance, the risk of bias was expressed in exposure misclassification, selective participation and confounding. The update yielded 87 papers, pertaining to 108 new studies of which 40 new studies were on annoyance, 42 on sleep disturbance and 26 concerning cardiovascular and metabolic effects. The number, size and quality of the new studies suggest new meta-analyses could be undertaken over the sources and effects included in the WHO reviews.
Multilevel analysis of hemodialysis-associated infection among end-stage renal disease patients: results of a retrospective cohort study utilizing the insurance claim data of Fukuoka Prefecture, Japan

Abstract The presence of comorbid conditions along with heterogeneity in terms of healthcare practices and service delivery could have a significant impact on the patient's outcomes. With a strong interest in social epidemiology to examine the impact of health services and variations on health outcomes, the current study was conducted to analyse the incidence of hemodialysis-associated infection (HAI) as well as its associated factors, and to quantify the extent to which the contextual effects of the care facility and regional variations influence the risk of HAI. A total of 6111 patients with end-stage renal disease who received hemodialysis treatment between 1 October 2015 and 31 March 2016 were identified from the insurance claim database as a population-based, close-cohort retrospective study. Patients were followed for one year from April 1, 2016 to March 31, 2017. A total of 200 HAI cases were observed during the follow-up and 12 patients died within 90 days of the onset of HAI. Increased risks for HAI were associated with moderate (HR 1.73, 95% confidence interval [CI] 1.00–2.98) and severe (HR 1.87, 95% CI 1.11–3.14) comorbid conditions as well as malignancy (HR 1.36, 95% CI 1.00–1.85). Increased risk was also seen among patients who received hemodialysis treatment from clinics (HR 2.49, 95% CI 1.1–5.33). However, these statistics were no longer significant when variations at the level of care facilities were statistically controlled. In univariate analyses, no statistically significant association was observed between 90-day mortality and baseline patients, and the characteristics of the care facility. The results of the multivariate, multilevel analyses indicated that HAI variations were only significant at the care facility level (σ2 2.07, 95% CI 1.3–3.2) and were largely explained by the heterogeneity between care facilities. The results of this study highlight the need to look beyond the influence of patient-level characteristics when developing policies that aim at improving the quality of hemodialysis healthcare and service delivery in Japan.
Alumina-based Coating for Coke Reduction in Steam Crackers

Alumina-based coatings have been claimed as being an advantageous modification in industrial ethylene furnaces. In this work, on-line experimentally measured coking rates of a commercial coating (CoatAlloy™) have pointed out its superiority compared to an uncoated reference material in an electrobalance set-up. Additionally, the effects of presulfiding with 500 ppmw DMDS per H2O, continuous addition of 41 ppmw S per HC of DMDS, and a combination thereof were evaluated during ethane steam cracking under industrially relevant conditions (Tgasphase = 1173 K, Ptot = 0.1 MPa, XC2H6 = 70%, dilution δ = 0.33 kgH2O/kgHC). The examined samples were further evaluated using online thermogravimetry, scanning electron microscopy and energy diffractive X-ray for surface and cross-section analysis together with X-ray photoelectron spectroscopy and wavelength-dispersive X-ray spectroscopy for surface analysis. The passivating coating illustrated a better performance than the reference Ni-Cr Fe-base alloy after application of an improved pretreatment, followed by piddling changes on the product distribution. Presulfiding of the coating affected negatively the observed coking rates in comparison with the reference alloy, so alternative presulfiding and sulfur addition strategies are recommended when using this barrier coating.
A year-long observation of water exchange between the North Pacific and the Bering Sea

Knowledge of the exchange of waters between the North Pacific Ocean and Bering Sea is limited because of the lack of reliable measurements. Existing estimates of flow through the major pass (Amchitka) in the Aleutian Islands were disparate and based on short-term data. A 1-yr series of direct current measurements was obtained in this pass, which revealed a northward flow of warm Alaskan Stream water into the Bering Sea. An estimate of volume transport gave 2-3 x lo6 m3 s-l, which is 10-l 5% of the transport of the Alaskan Stream. The Aleutian island arc forms a partial barrier to water exchange between the North Acknowledgments I thank W. Parker and P. Proctor for their efforts in data retrieval and processing. J. D. Schumacher and P. J. Stabeno provided support and advice. The studies of this region by F. Favorite were of great interest to me. This is a contribution (FOCI-O 107) to the Fisheries Oceanography Coordinated Investigations of NOAA. Contribution 1117 from NOAA/Pacific Marine Environmental Laboratory. Pacific Ocean and the Bering Sea (Fig. 1). West of Attu Island (173”E), essentially unrestricted transport of upper-ocean and deep waters is possible. To the east, however, there are only three passes that would permit significant flow of water across the Aleutian arc (Favorite 1967). These passes (with cross-sectional areas) are Amukta (19 km*), Amchitka (46 km*), and Buldir (28 km*). Amchitka has an area about double the others and is the only pass that would allow exchange of waters deeper than -600 m. The need for a long time series of data through this major pass led to the current measurements reported here. Anecdotal reports implied that flow was northward through most Aleutian passes, but early editions of the Coast Pilot (U.S. Dep. Commerce 195 5) refuted this idea. Furthermore, additional analyses of the limited, short-duration current measure-
Protein Kinase A Catalytic and Regulatory Subunits Interact Differently in Various Areas of Mouse Brain

Protein kinase A (PKA) are tetramers of two catalytic and two regulatory subunits, docked at precise intracellular sites to provide localized phosphorylating activity, triggered by cAMP binding to regulatory subunits and subsequent dissociation of catalytic subunits. It is unclear whether in the brain PKA dissociated subunits may also be found. PKA catalytic subunit was examined in various mouse brain areas using immunofluorescence, equilibrium binding and western blot, to reveal its location in comparison to regulatory subunits type RI and RII. In the cerebral cortex, catalytic subunits colocalized with clusters of RI, yet not all RI clusters were bound to catalytic subunits. In stria terminalis, catalytic subunits were in proximity to RI but separated from them. Catalytic subunits clusters were also present in the corpus striatum, where RII clusters were detected, whereas RI clusters were absent. Upon cAMP addition, the distribution of regulatory subunits did not change, while catalytic subunits were completely released from regulatory subunits. Unpredictably, catalytic subunits were not solubilized; instead, they re-targeted to other binding sites within the tissue, suggesting local macromolecular reorganization. Hence, the interactions between catalytic and regulatory subunits of protein kinase A consistently vary in different brain areas, supporting the idea of multiple interaction patterns.
Efficacy of the eCHECKUP TO GO for High School Seniors: Sex Differences in Risk Factors, Protective Behavioral Strategies, and Alcohol Use.

OBJECTIVE The purpose of this randomized controlled study was to examine sex as a moderator of the efficacy of a brief, web-based personalized feedback intervention (eCHECKUP TO GO) on decreasing cognitive risk factors for alcohol use, increasing protective behavioral strategies, and reducing alcohol use among high school seniors. METHOD Participants (n = 311) were high school seniors randomized by class period to the eCHECKUP TO GO intervention or assessment-only control group. Participants completed online surveys at baseline and 30-day follow-up (91.0%; n = 283). RESULTS Students in the intervention group reported a significant reduction in normative perceptions of peer drinking, positive alcohol expectancies, and alcohol use relative to those in the control group. Intervention effects for perceptions of frequency of peer drunkenness and frequency of alcohol use were moderated by sex, with results favoring females. In contrast, we did not find evidence for sex as a moderator of intervention effects for normative perceptions of peer drinking frequency, sex-specific perceptions of peer heavy episodic drinking, positive alcohol expectancies, or peak drinking quantity. Further, we did not find significant intervention or moderator effects for protective behavioral strategies. CONCLUSIONS Results of this study extend the literature by demonstrating the efficacy of the eCHECKUP TO GO for both males and females on reducing cognitive risk factors and alcohol use, although results were significant for a broader range of variables for females. Results also indicate that program content regarding normative feedback and protective behavioral strategies may need modification to be more effective for this age group.
Silage-concentrate finishing of bulls versus silage or fresh forage finishing of steers: Effects on fatty acids and meat tenderness

Abstract The objective of this trial was to assess meat quality in terms of tenderness and fatty acid (FA) composition in M. longissimus dorsi and M. gluteus medius from bulls finished on ad lib silage-concentrates (SIL:CON) vs. steers fed ad lib silage (FF) or restricted silage and unrestricted grazing (RES-F). Warner-Brazler shear force value day 1 was lowest for the FF steers (p<0.05). Myofibril fragmentation index (MFI) values were similar after seven days of ageing, showing that ageing compensated for differences in meat tenderness associated with feeding programmes. Total monounsaturated FAs and 18:1c-9 levels were higher in the steer tissue (p<0.001). The SIL:CON bulls had higher polyunsaturated n-6 fatty acids and 18:2n-6 level (p<0.001). Polar lipid 18:2n-6 and n-6 levels were higher for FF than for RES-F steers, whereas the 18:3n-3 level was higher for RES-F than for FF steers (p<0.001). The n-6/n-3 ratio was lowest for the FF steers and highest for the SIL:CON bulls (p<0.001).
Study of historical evacuation drill data combining regression analysis and dimensionless numbers

The time needed to evacuate a building depends on many factors. Some are related to people’s behavior, while others are related to the physical characteristics of the building. This paper analyzes the historical data of 47 evacuation drills in 15 different university buildings, both academic and residential, involving more than 19 000 persons. We propose the study of the data presented using a dimensionless analysis and statistical regression in order to give a prediction of the ratio between exit time and the number of people evacuated. The results obtained show that this approach could be a useful tool for comparing buildings of this type, and that it represents a promising research topic which can also be extended to other types of buildings.
Actions of Rab27B‐GTPase on mammalian central excitatory synaptic transmission

Members of the Rab3 gene family are considered central to membrane trafficking of synaptic vesicles at mammalian central excitatory synapses. Recent evidence, however, indicates that the Rab27B‐GTPase, which is highly homologous to the Rab3 family, is also enriched on SV membranes and co‐localize with Rab3A and Synaptotagmin at presynaptic terminals. While functional roles of Rab3A have been well‐established, little functional information exists on the role of Rab27B in synaptic transmission. Here we report on functional effects of Rab27B at SC‐CA1 and DG‐MF hippocampal synapses. The data establish distinct functional actions of Rab27B and demonstrate functions of Rab27B that differ between SC‐CA1 and DG‐MF synapses. Rab27B knockout reduced frequency facilitation compared to wild‐type (WT) controls at the DG/MF‐CA3 synaptic region, while increasing facilitation at the SC‐CA1 synaptic region. Remarkably, Rab27B KO resulted in a complete elimination of LTP at the MF‐CA3 synapse with no effect at the SC‐CA1 synapse. These actions are similar to those previously reported for Rab3A KO. Specificity of action on LTP to Rab27B was confirmed as LTP was rescued in response to lentiviral infection and expression of human Rab27B, but not to GFP, in the DG in the Rab27B KO mice. Notably, the effect of Rab27B KO on MF‐CA3 LTP occurred in spite of continued expression of Rab3A in the Rab27B KO. Overall, the results provide a novel perspective in suggesting that Rab27B and Rab3A act synergistically, perhaps via sequential effector recruitment or signaling for presynaptic LTP expression in this hippocampal synaptic region.
Asthma and COVID‐19: Is asthma a risk factor for severe outcomes?

When I first read the manuscript that accompanies this editorial, upon its online publication on February 19th 2020(1), COVID-19 had already killed 2118 people in China, but only one person in Europe - an 80-year-old tourist from China, who died in France on the 15th February. I read the manuscript with grim fascination, as it was clear that SARS-CoV-2 had spread very rapidly in China which already had 74,576 cases and in South Korea which already had 58 cases, and that it was then invading Europe also, as France already had 12 cases, Germany 16, the UK 9, Italy 3, Spain 2 and other countries too.
Comment on Influence of Serving Temperature and Wine Type on Perception of Ethyl Acetate and 4-Ethyl Phenol in Wine

In their article, Cliff and King (Journal of Wine Research, 2009, Volume 20, Number 1, pp. 45–52) present a study examining the influence of serving temperature and wine type on perception of ethyl acetate and 4-ethylphenol in a blended red wine sample of unspecified composition, a blended white wine sample of unspecified composition, a Gewurztraminer white wine, and a Chardonnay white wine. This Comment will address a number of scientific concerns in the manuscript that require discussion. Throughout their manuscript, Cliff and King (2009) have not discussed any relevant studies regarding the reported levels of ethyl acetate or 4-ethylphenol in commercial wines. Such integration of these well established fields of research is required to both contextualize and integrate Cliff and King’s (2009) findings into the broader scientific literature. With respect to 4-ethylphenol, it is important to note that published peer reviewed surveys of this compound in commercial wines have reported average concentrations of 3mgL (range: 0 to 28mgL) and 440mgL (range: 1 to 6,000mgL) in white and red wines, respectively, from France (Chatonnet et al., 1992), an average concentration of 795mg L (range: 2 to 2,700mgL) in redwines fromAustralia (Pollnitz et al., 2000a,b), and average/median concentrations of 56/29 mg L (range: ,0.5 to 544 mg L; .99.5% of all samples had concentrations ,500 mg L and .97% of all samples had concentrations ,100 mg L), respectively, in red wines from the Okanagan Valley of British Columbia, Canada (Rayne and Eggers, 2007, 2008). In addition, the sensory impacts of Brettanomyces derived organoleptic defaults, of which 4-ethylphenol is one contributing compound, have been the subject of much recent attention since the early work of Chatonnet (1993) that is the only citation provided by Cliff and King (2009) with regard to 4-ethylphenol and/or Brettanomyces. These post-1993 works warranted integration (see recent reviews by Snowdon et al. (2006), Renouf et al. (2007), Suarez et al. (2007), and Oelofse et al. (2008), the sensory work by Romano et al. (2009), and references in these publications therein). Similarly, a significant quantity of research has been conducted on ethyl acetate concentrations in wine and associated sensory impacts. For example, wine rejection levels of ,200 mg L have been developed for ethyl acetate (Corison et al., 1979), and concentrations of this compound can range widely over several orders of magnitude from