Miracle-dz/UniFAR-FTUs huggingface dataset:
Virialisation-induced curvature as a physical explanation for dark energy

The geometry of the dark energy and cold dark matter dominated cosmological model (LambdaCDM) is commonly assumed to be given by a Friedmann-Lemaitre-Robertson-Walker (FLRW) metric, i.e. it assumes homogeneity in the comoving spatial section. The homogeneity assumption fails most strongly at (i) small distance scales and (ii) recent epochs, implying that the FLRW approximation is most likely to fail at these scales. We use the virialisation fraction to quantify (i) and (ii), which approximately coincide with each other on the observational past light cone. For increasing time, the virialisation fraction increases above 10% at about the same redshift (sim 1-3) at which Omega_Lambda grows above 10% (approx 1.8). Thus, instead of non-zero Omega_Lambda, we propose an approximate, general-relativistic correction to the matter-dominated (Omega_m =1, Omega_Lambda=0), homogeneous metric (Einstein de Sitter, EdS). A low-redshift effective matter-density parameter of Omega_m^eff(0) = 0.26 pm 0.05 is inferred. Over redshifts 0 < z < 3, the distance modulus of the virialisation-corrected EdS model approximately matches the LambdaCDM distance modulus. This rough approximation assumes "old physics" (general relativity), not "new physics". Thus, pending more detailed calculations, we strengthen the claim that "dark energy" should be considered as an artefact of emerging average curvature in the void-dominated Universe, via a novel approach that quantifies the relation between virialisation and average curvature evolution.
A New Treatment Protocol of Combined High-Dose Levothyroxine and Repetitive Transcranial Magnetic Stimulation for the Treatment of Rapid-Cycling Bipolar Spectrum Disorders: A Cohort Evaluation of 55 Patients

Background: Bipolar spectrum disorders (BSD) are highly disabling, with rapid cycling being treatment resistant. High-dose levothyroxine (HDT) has been reported to be effective. Diagnosis is associated with mutations in thyroid-activating enzymes and cerebral transporter protein carrier. Repetitive transcranial magnetic stimulation (rTMS) has neuroplastic effects. Methods: We report data on 55 severely symptomatic patients with rapid-cycling BSD treated with a combination protocol of HDT and rTMS. Of the patients, 31 patients (56.4%) were female and 40 (72.7%) had at least one additional diagnosis. Results: Patients were evaluated at three monthly intervals after acute treatment. Remission was measured using the Sheehan Disability Scale (SDS). The average number of medications prescribed was 1.8, with 32 patients (58.2%) needing only levothyroxine. The average dose of levothyroxine was 303.7 mcg (50 mcg–1000 mcg). A total of 53 patients were in remission (96.4%), with an average duration of 2.0 years. The SDS scores decreased significantly (Cohen’s d = 2.61 (95% C.I. 1.81 to 2.83, p < 0.001). One patient had reversible side effects. A total of 52 (94.3%) patients had Deiodinase 1 and 2 (DiO1/DiO2) or SLCO1C1 protein carrier gene mutations. Conclusion: The data support the safety and acceptability of combined HDT/rTMS. Patients achieved long remissions with substantial improvements in quality of life.
Influence of Fe2O3, MgO and Molarity of NaOH Solution on the Mechanical Properties of Fly Ash-Based Geopolymers

The use of waste from industrial activities is of particular importance for environmental protection. Fly ash has a high potential in the production of construction materials. In the present study, the use of fly ash in the production of geopolymer paste and the effect of Fe2O3, MgO and molarity of NaOH solution on the mechanical strength of geopolymer paste are presented. Samples resulting from the heat treatment of the geopolymer paste were subjected to mechanical tests and SEM, EDS and XRD analyses. Samples were obtained using 6 molar and 8 molar NaOH solution with and without the addition of Fe2O3 and MgO. Samples obtained using a 6 molar NaOH solution where Fe2O3 and MgO were added had higher mechanical strengths compared to the other samples.
Weakly repelling fixpoints and the connectivity of wandering domains

It is proved that if a transcendental meromorphic function f has a multiply-connected wandering domain, then f has a (cid:12)xpoint z 0 such that j f 0 ( z 0 ) j > 1 or f 0 ( z 0 ) = 1. Entire functions with a multiply-connected wandering domain have in(cid:12)nitely many such (cid:12)xpoints. These results are used to show that solutions of certain di(cid:11)erential equations do not have wandering domains at all.
Nursing and Midwifery Managers’ Views on Compassion in Daily Practice: A Survey in Greece and Cyprus

Compassionate care is a key component in nursing and midwifery quality care. It leads to positive patient outcomes, greater patient satisfaction, higher level of compliance, lower costs and reduction of nurse’s burnout. The aim of this article is to describe how nurses’ and midwives’ managers understand and practice compassion in Cyprus and Greece. This is a cross-sectional, descriptive, exploratory online survey using close and open-ended questions. Descriptive statistics and thematic analysis were applied. This is part of a larger study participating 17 countries. This article discusses Cyprus (Greek-Cypriots n = 47) and Greece data (n = 58). The sample included nurses and/or midwives in management positions, nurse educators/managers in the hospital, community or in educational setting. Participants in this study reported the necessity to be a compassionate manager. Some stated that nurses and midwives do not receive compassion from their managers. Thematic areas revealed include: (a) Defining compassion, (b) Giving/receiving compassion, (c) Manager as advocate (d) Importance of cultural characteristics (e) Advantages/barriers of compassion. Managing and leading staff with compassion have a positive effect in the quality, effectiveness and efficiency in daily practice. It enhances work satisfaction. Nurses’ and midwives’ managers in Cyprus and Greece highlight the importance of reinforcing themselves in providing compassionate care and supporting their staff.
Properties of submillimetre galaxies in a semi-analytic model using the `Count Matching' approach: application to the ECDF-S

We present a new technique for modeling submillimeter galaxies (SMGs): the “Count Matching” approach. Using lightcones drawn from a semi-analytic model of galaxy formation, we choose physical galaxy properties given by the model as proxies for their submillimeter luminosities, assuming a monotonic relationship. As recent interferometric observations of the Extended Chandra Deep Field South show that the brightest sources detected by single-dish telescopes are comprised by emission from multiple fainter sources, we assign the submillimeter fluxes so that the combined LABOCA plus bright-end ALMA observed number counts for this field are reproduced. After turning the model catalogs g iven by the proxies into submillimeter maps, we perform a source extraction to include the effects of the observational process on the recovered counts and galaxy properties. We fin d that for all proxies, there are lines of sight giving counts consistent with those derived f rom LABOCA observations, even for input sources with randomized positions in the simulated map. Comparing the recovered redshift, stellar mass and host halo mass distributions for model SMGs with observational data, we find that the best among the proposed proxies is that i n which the submillimeter luminosity increases monotonically with the product between dust mass and SFR. This proxy naturally reproduces a positive trend between SFR and bolometric IR luminosity. The majority of components of blended sources are spatially unassociated.
Dynamic Ranges of Retinal Nerve Fiber and Optic Nerve Head Parameters Measured Using Optical Coherence Tomography in Glaucoma: A Longitudinal Study

Purpose To evaluate the dynamic range of retinal nerve fiber layer (RNFL) and optic nerve head (ONH) parameters measured using optical coherence tomography (OCT) in conditions ranging from nonglaucomatous status to advanced glaucoma by longitudinal observation. Methods A total of 15 eyes from 12 participants with glaucoma progression from a nonglaucomatous status to advanced glaucoma were included. The RNFL and ONH parameters were compared between the nonglaucomatous and advanced stages within the same eye. The absolute and relative changes in OCT parameters were analyzed. Results The median highest intraocular pressure was 42.5 mmHg (interquartile range, 37.5 to 54.5 mmHg), and the final mean deviation of the visual field test was −24.68 dB (interquartile range, −23.93 to −31.13 dB). The median relative changes in RNFL thickness were −40.6% in the overall area, and −51.9%, −21.4%, −51.1%, and −41.8% in the superior, nasal, inferior, and temporal quadrants, respectively (all p < 0.05). Relative changes in the rim area, disc area, average cup to disc ratio, vertical cup to disc ratio, and cup volume were −56.64%, 0.59%, 62.10%, 66.0%, and 337.90%, respectively (all p < 0.05, except for disc area with a p-value of 0.753). Conclusions The dynamic range of the RNFL thickness ranged from 40.6% to 51.9%, and the dynamic range of the ONH parameters ranged from 56.64% to 337.90%. During the course of glaucoma progression, the cup volume showed the widest dynamic range. However, the disc area did not show significant changes.
Calcium-Related Genes Predicting Outcomes and Serving as Therapeutic Targets in Endometrial Cancer

Endometrial cancer (EC) is the most common gynecologic cancer with increasing incidence. The dysregulation of intracellular calcium plays a crucial role in cancer progression. However, the relationship between calcium-related genes and prognosis remains unclear. In this study, we aimed to establish a risk model based on calcium-related genes for prognosis prediction in patients with EC. The TCGA-total set was divided into a training set and a testing set (1:1). The four-gene prognostic signature (CACNA2D1, SLC8A1, TRPM4 and CCL2) was established and classified all EC patients into a low-risk or high-risk group. This model was validated in both the testing dataset and the total set. The EC patients with high RiskScores showed significantly shorter overall survival than those with low RiskScores, and this trend was consistent among most subgroups. Moreover, an enrichment analysis confirmed that calcium-related and estrogen-response signalings were significantly enriched in the high-risk group. The knockdown of CACNA2D1 by siRNA or its blocker, amlodipine (AM) inhibited cell proliferation and induced cycle arrest in vitro. The calcium channel blocker AM inhibited cell proliferation and induced cycle arrest in vitro. AM also showed marked tumor inhibition effects in vivo. In summary, the prognostic model constructed by four calcium-related genes can reliably predict the outcomes of EC patients, and a calcium channel blocker, AM, has significant potential for EC treatment.
Transcriptome Profiling of the Hippocampal Seizure Network Implicates a Role for Wnt Signaling during Epileptogenesis in a Mouse Model of Temporal Lobe Epilepsy

Mesial temporal lobe epilepsy (mTLE) is a life-threatening condition characterized by recurrent hippocampal seizures. mTLE can develop after exposure to risk factors such as febrile seizure, trauma, and infection. Within the latent period between exposure and onset of epilepsy, pathological remodeling events occur that contribute to epileptogenesis. The molecular mechanisms responsible are currently unclear. We used the mouse intrahippocampal kainite model of mTLE to investigate transcriptional dysregulation in the ipsilateral and contralateral dentate gyrus (DG), representing the epileptogenic zone (EZ) and peri-ictal zone (PIZ). DG were analyzed after 3, 7, and 14 days by RNA sequencing. In both the EZ and PIZ, transcriptional dysregulation was dynamic over the epileptogenic period with early expression of genes representing cell signaling, migration, and proliferation. Canonical Wnt signaling was upregulated in the EZ and PIZ at 3 days. Expression of inflammatory genes differed between the EZ and PIZ, with early expression after 3 days in the PIZ and delayed expression after 7–14 days in the EZ. This suggests that critical gene changes occur early in the hippocampal seizure network and that Wnt signaling may play a role within the latent epileptogenic period. These findings may help to identify novel therapeutic targets that could prevent epileptogenesis.
Global existence of mild solutions to semilinear differential equations in Banach spaces

Soit X un espace de Banach sur le corps reel R de norme |•|. Soit {S(t); t≥0} un semigroupe lineaire de contraction sur X de classe (C 0 ) et soit A le generateur infinitesimal de {S(t); t≥0}. Soit Ω un sous-ensemble de [a, b]×X(a<b≤+∞) et soit B un operateur continu non lineaire de Ω dans X. On etudie l'existence et l'unicite des solutions globales du probleme aux valeurs initiales pour l'equation semi-lineaire: u(t)=Au(t)+B(t, u(t)), τ<t<b, u(τ)=z, ou (τ, z)∈Ω
A spectroscopic survey of Andromeda's Western Shelf

The Andromeda galaxy (M31) shows many tidal features in its halo, including the Giant Southern Stream (GSS) and a sharp ledge in surface density on its western side (the W Shelf). Using DEIMOS on the Keck telescope, we obtain radial velocities of M31’s giant stars along its NW minor axis, in a radial range covering the W Shelf and extending beyond its edge. In the space of velocity versus radius, the sample shows the wedge pattern expected from a radial shell, which is detected clearly here for the first tim e. This confirms predictions from an earlier model of formation of the GSS, which proposed that the W Shelf is a shell from the third orbital wrap of the same tidal debris stream that pr oduces the GSS, with the main body of the progenitor lying in the second wrap. We calculate the distortions in the shelf wedge pattern expected from its outward expansion and angular momentum, and show that these effects are echoed in the data. In addition, a hot, rela tively smooth spheroid population is clearly present. We construct a bulge-disk-halo N-body model that agrees with surface brightness and kinematic constraints, and combine it with a simulation of the GSS. From the contrasting kinematic signatures of the hot spheroid and sh elf components, we decompose the observed stellar metallicity distribution into contribut ions from each component using a nonparametric mixture model. The shelf component’s metallici ty distribution matches previous observations of the GSS superbly, further strengthening th e evidence they are connected and bolstering the case for a massive progenitor of this stream.
The Role of Boundary Mixing for Diapycnal Oxygen Fluxes in a Stratified Marine System

Insufficient diapycnal oxygen transport through the halocline is the key reason for the anoxic conditions typically observed in the deeper parts of the Baltic Sea. The variability of turbulent oxygen fluxes through the halocline was investigated seasonally and in space during three cruises (summer, fall, winter). Turbulence dissipation rates and oxygen fluxes showed a pronounced seasonal pattern, with the lowest values during summer. At the basin boundaries, halocline oxygen fluxes increased by an order of magnitude as a result of boundary mixing. A simple box model, distinguishing between interior, intermediate, and boundary regions, was used to extrapolate the locally observed fluxes to the central Baltic Sea. The boundary area, covering less than 23% of the total basin area, contributed more than 80% of the basin‐scale oxygen transport through the halocline. According to this model, the annual oxygen flux through the halocline is of the order of 20–28 Gmol per year.
Cinnamon Leaf and Clove Essential Oils Are Potent Inhibitors of Candida albicans Virulence Traits

Plant-based essential oils are promising anti-virulence agents against the multidrug-resistant opportunistic pathogen Candida albicans. Gas chromatography–mass spectrometry of Cinnamomum zeylanicum (cinnamon) leaf and Eugenia caryophyllus (clove) flower bud essential oils revealed eugenol (73 and 75%, respectively) as their major component, with β-caryophyllene, eugenyl acetate, and α-humulene as common minor components. Cinnamon leaf and clove essential oils had minimum inhibitory concentrations of 600 and 500 µg/mL, respectively against the C. albicans RSY150 reference strain and 1000 and 750 µg/mL, respectively for the clinical reference strain ATCC 10231. The combined oils are additive (FICI = 0.72 ± 0.16) and synergistic (0.5 ± 0.0) against RSY150 and the clinical reference strain, respectively. Mycelial growth was inhibited by sublethal concentrations of either essential oil, which abolished colony growth. At half of the lowest combined lethal concentration for the two oils, the yeast-to-hyphal transition and mycelial growth was potently inhibited. Mutant strains als1Δ/Δ, als3Δ/Δ, hwp1Δ/HWP1+, and efg1Δ/Δ were sensitive to either or both oils, especially efg1Δ/Δ. In conclusion, oils of cinnamon leaf and clove and their combination significantly impact C. albicans virulence by inhibiting hyphal and mycelial growth.
Stellar Streams as Probes of Dark Halo Mass and Morphology: A Bayesian Reconstruction

Tidal streams provide a powerful tool by means of which the matter distribution of the dark matter haloes of their host galaxies can be studied. However, the analysis is not straightforward because streams do not delineate orbits, and for most streams, especially those in external galaxies, kinematic information is absent. We present a method wherein streams are fitted with simple corrections made to possible orbits of the progenitor, using a Bayesian technique known as parallel tempering to efficiently explore the parameter space. We show that it is possible to constrain the shape of the host halo potential or its density distribution using only the projection of tidal streams on the sky, if the host halo is considered to be axisymmetric. By adding kinematic data or the circular velocity curve of the host to the fitting data, we are able to recover other parameters of the matter distribution such as its mass and profile. We test our method on several simulated low-mass stellar streams and also explore the cases for which additional data are required.
Reduction of greenhouse gas emissions in an imperfect production process under breakdown consideration

A long-run manufacturing system can experience machine breakdown at any time for various reasons such as unskilled labor or outdated machinery technology. In an integrated green inventory model, the produced green products cannot all be perfect throughout a cycle, particularly when machines malfunction. Therefore, an inspection policy is introduced to clean the production process from unusable defect products, the correctness of which depends on the discussion of the inspected errors. The perfect products detected via the inspection process are delivered to the retailer as well as the market. To transport green products, it is essential to control the capacity of the containers and the quantities of green products transported per batch. In this study, the greenhouse gas equivalence factor of CO$ _2 $ emissions is calculated for all green products' manufacturing and transportation mediums. These types of energies are used in the manufacturing process: electricity, natural gas, and coal. Whereas within transportation, four transportation modes are considered: railways, roadways, airways, and waterways. The retailer can agree to transport their inventories to the customers' house according to their requirement by requiring a third-party local agency via outsourcing criteria. The model solves the problem of CO$ _2 $ emissions through production and transportation within the machine breakdown.
Effects and Complications of Subcutaneous Implantable Cardioverter-Defibrillator in the Prevention of Sudden Cardiac Death: A Narrative Review

An implantable cardioverter-defibrillator (ICD) is one of those devices that is a big boom for the prevention of sudden deaths due to heart failure. This particular device has been in use for just a couple of years, but its impact in the domain has brought about a considerable change in the way a specific issue of the cardiovascular system is tackled. Although subcutaneous or hypodermic implantable cardioverter-defibrillator (S-ICD) is considered to be a better alternative as far as transvenous implantable cardioverter-defibrillator (TV-ICD) is concerned, the former, being a newer introduction in the market, needs to be assessed in depth to clearly understand its effects and complications. Various types of research have been conducted on the efficacy of this device, and in most of the studies, the supremacy of this device is clearly evident when compared with other devices that are used for the same purpose. Better innovations in subcutaneous or hypodermic implantable cardioverter-defibrillators would enable them to be manufactured in a more efficient and cost-effective way so that a huge lot of people are benefited from this device. This review article is a whole peep into the various studies done in this domain, thereby providing adequate scientific insights about subcutaneous or hypodermic implantable cardioverter-defibrillators in a very simple and comprehensive manner.
A general theory of linear cosmological perturbations: bimetric theories

We implement the method developed in [1] to construct the most general parametrised action for linear cosmological perturbations of bimetric theories of gravity. Specifically, we consider perturbations around a homogeneous and isotropic background, and identify the complete form of the action invariant under diffeomorphism transformations, as well as the number of free parameters characterising this cosmological class of theories. We discuss, in detail, the case without derivative interactions, and compare our results with those found in massive bigravity.
Paternalistic Leadership Styles and Employee Voice: The Roles of Trust in Supervisors and Self-Efficacy

The purpose of this paper is to test the role of trust in supervisors in mediating the link between paternalistic leadership styles and employee voice and to investigate the contingency role of self-efficacy on the relationship between trust in supervisors and employee voices. We designed the items using survey questionnaires that were assessed by prior studies and collected data from 485 highly skilled employees of manufacturing organizations. To assess the validity of the suggested hypotheses, we used a Baron and Kenny (1986) approach and conducted hierarchical regression analysis. The findings reveal that authoritarian leadership and moral leadership styles are significantly related to trust in supervisors, which explains the association between authoritarian leadership style, and moral leadership style and employee voice. However, the results suggest that trust in supervisors does not explain the association between benevolent leadership style and employee voice. Moreover, the findings reveal that self-efficacy moderates the link between trust in supervisors and employee voice. The originality of this work lies in the fact that this research is the first to test the mediating role of trust in supervisors in the relationship between paternalistic leadership styles and employee voice and the moderating role of self-efficacy on the association between trust in supervisors and employee voice.