Miracle-dz/UniFAR-FTUs huggingface dataset:
ESTIMATE OF HETEROSIS AND HETEROBELTIOSIS FOR THE IMPROVEMENT OF YIELD IN UPLAND COTTON (GOSSYPIUM HIRSUTUM L.)

The enhancing seed cotton yield per acre of the crop is a prime concern of breeding programmes. To achieve high degree of heterotic response, it is essential to have knowledge about performance of desirable parents . Therefore, research was undertaken to assess the expression of heterotic effects in cross combination of upland cotton in F1 crosses. The research work was carried out using six cross combinations sown under field condition during 2018 at Nuclear Institute of Agriculture, Tandojam experimental farm. The crosses were obtained by the combinations of four genotypes in half diallel method. The trial was conducted in a three replications with Randomized Complete Block Design (RCBD). Observations were made for plant height (cm), sympodial branches plant-1, number of bolls plant-1 , weight boll (g) and yield of plant-1 (g). Results showed that crosses exhibited significant cross vigour while compared with mid and better parents. The crosses Sadori × CRIS-342 and Sadori × NIA-Noori displayed significant heterotic effects for characters under studied. For development of hybrid in cotton, cross combinations of these parents Sadori × CRIS-342 and Sadori × NIA-Noori will give highest heterosis for yield of plant-1, bolls plant-1 and weight of bolls. Therefore, the above F1 transgressive and heterotic hybrids can be exploited to create genetic variability followed by selection of high yielding in cotton genotypes to establish strains with superior and improved characteristics in segregating filial generations.
Anthocyanins Found in Pinot Noir Waste Induce Target Genes Related to the Nrf2 Signalling in Endothelial Cells

Grape pomace is a source of anthocyanins, which can prevent cardiovascular diseases due to their antioxidant properties. Anthocyanin activity is associated with the ability to regulate oxidative stress through the transcription factor Nrf2. Thus, the present study aimed to evaluate if the anthocyanins found in Pinot noir pomace extract can affect the target genes related to the Nrf2 signalling pathway in endothelial cells. Our results highlight that the predominant anthocyanin in the Pinot noir pomace extract was malvidin-3-glucoside (3.7 ± 2.7 Eq. Malv-3-glu/kg). Molecular docking indicated that cyanidin-3-glucoside (−6.9 kcal/mol), malvidin-3-glucoside (−6.6 kcal/mol) and peonidin-3-glucoside (−6.6 kcal/mol) showed the highest affinities for the binding sites of the BTB domains in Keap1, suggesting that these components may modify the interaction of this protein with Nrf2. In addition, when HUVEC cells were exposed to different concentrations of Pinot noir pomace extract (100 µg/mL, 200 µg/mL, and 400 µg/mL), no changes in Nrf2 gene expression were observed. However, the gene expression of HO-1 and NQO1, which are in the signalling pathway of this transcription factor, increased according the concentrations of the extract (p = 0.0004 and p = 0.0084, respectively). In summary, our results show that anthocyanins play a very important role in Nrf2 activation and release, while at the same time not promoting its transcription. These preliminary results strongly suggest that the Pinot noir pomace extract can serve as a potent bioactive component source that protects cells against oxidative stress.
A geometric approach to the Proinov type contractions

In this paper, we prove some fixed-circle, fixed-disc and fixed-ellipse results on metric spaces. To do this, we define the notions of Proinov type a0-contraction and generalized Proinov type a0-contraction. Also, we give some illustrative examples to show the validity of our obtained results. Finally, we present a nice application to exponential linear unit activation functions.
“Why Would I Talk To Them About Sex?”: Exploring Patient-Provider Communication Among Black Women Experiencing Sexual Pain

Ineffective patient-provider communication poses a potential health risk to Black women if medical providers are not addressing their needs or concerns. Additionally, less than half of OBGYNs report asking their patients about sexual difficulties, which limits women’s opportunities to disclose their experiences of sexual pain. The purpose of this qualitative study is to explore Black women’s experiences of patient-provider communication about sexual pain (reoccurring unwanted genital pain). Specifically, we aimed to describe the pathway from sexual pain disclosure to treatment among N = 25 premenopausal Black women living in the southern United States who were experiencing sexual pain. Using constructivist grounded theory, open-ended responses to six interview questions related to healthcare experiences, treatment, and patient-provider communication were qualitatively analyzed and categorized to form a conceptual framework of patient-provider communication about sexual pain. Five key categories emerged related to Black women’s experiences with their medical providers regarding sexual pain: (1) provider preferences, (2) healthcare experiences, (3) reasons for non-disclosure, (4) provider responses to sexual pain, and (5) treatment for sexual pain. Useful strategies to improve patient-provider communication are presented for both patients and providers.
Understanding Sensitization, Cognitive and Neuropathic Associated Mechanisms behind Post-COVID Pain: A Network Analysis

This study aimed to describe a network including demographic, sensory-related, psychological/cognitive and other variables in individuals with post-COVID pain after hospitalization. Demographic (i.e., age, height, weight, months with symptoms), sensory-related (Central Sensitization Inventory -CSI-, Self-Report Leeds Assessment of Neuropathic Symptoms -S-LANSS-, PainDETECT), psychological/cognitive (Hospital Anxiety and Depression Scale -HADS-A/HADS-D-, Pain Catastrophizing Scale -PCS-, Tampa Scale for Kinesiophobia -TSK-11-) and other (sleep quality and health-related quality of life -EQ/5D/5L) variables were collected in 146 COVID-19 survivors with post-COVID pain. A network analysis was conducted to quantify the adjusted correlations between the modelled variables, and to assess their centrality indices (i.e., the connectivity with other symptoms in the network and the importance in the system modelled as network). The network revealed associations between sensory-related and psychological/cognitive variables. PainDETECT was associated with S-LANSS (ρ: 0.388) and CSI (ρ: 0.207). Further, CSI was associated with HADS-A (ρ: 0.269), TSK-11 (ρ: 0.165) and female gender (ρ: 0.413). As expected, HADS-A was associated with HADS-D (ρ: 0.598) and TSK-11 with PCS (ρ: 0.405). The only negative association was between sleep quality and EQ-5D-5L (ρ: −0.162). Gender was the node showing the highest strength, closeness, and betweenness centralities. In addition, CSI was the node with the second highest closeness and betweenness centralities, whereas HADS-D was the node with the second highest strength centrality. This is the first study applying a network analysis for phenotyping post-COVID pain. Our findings support a model where sensitization-associated symptoms, neuropathic phenotype, and psychological aspects are connected, reflecting post-COVID pain as a nociplastic pain condition. In addition, post-COVID pain is gender dependent since female sex plays a relevant role. Clinical implications of current findings, e.g., developing treatments targeting these mechanisms, are discussed.
The Use of Thiocyanate Formulations to Create Manganese Porphyrin Antioxidants That Supplement Innate Immunity

The innate immune response to infection results in inflammation and oxidative damage, creating a paradox where most anti-inflammatory and antioxidant therapies can further suppress an already inadequate immune response. We have previously reported the beneficial effects of the exogenous supplementation of innate immunity with small pseudohalide thiocyanate (−SCN) in a mouse model of a cystic fibrosis (CF) lung infection and inflammation. The object of this study was to evaluate the use of −SCN as a counter anion for cationic manganese porphyrin (MnP) catalytic antioxidants, which could increase the parent compound’s antioxidant spectrum against hypohalous acids while supplementing innate immunity. The antioxidant activities of the parent compound were examined, as its chloride salt was compared with the −SCN-anion exchanged compound, (MnP(SCN) versus MnP(Cl)). We measured the superoxide dismutase activity spectrophotometrically and performed hydrogen peroxide scavenging using oxygen and hydrogen peroxide electrodes. Peroxidase activity was measured using an amplex red assay. The inhibition of lipid peroxidation was assessed using a thiobarbituric acid reactive species (TBARS) assay. The effects of the MnP compounds on macrophage phagocytosis were assessed by flow cytometry. The abilities of the MnP(Cl) formulations to protect human bronchiolar epithelial cells against hypochlorite (HOCl) and glycine chloramine versus their MnP(SCN) formulations were assessed using a cell viability assay. We found that anions exchanging out the chloride for −SCN improved the cellular bioavailability but did not adversely affect the cell viability or phagocytosis and that they switched hydrogen-peroxide scavenging from a dismutation reaction to a peroxidase reaction. In addition, the −SCN formulations improved the ability of MnPs to protect human bronchiolar epithelial cells against hypochlorous acid (HOCl) and glycine chloramine toxicity. These novel types of antioxidants may be more beneficial in treating lung disease that is associated with chronic infections or acute infectious exacerbations.
Design of high gain/directional ultra‐wideband antenna for radar imaging systems

A compact size of 40 × 40 mm2 ( λ0 × λ0) semi‐elliptical slotted ground structure (SESGS) directional ultra‐wideband (UWB) antenna is proposed for radar imaging applications. A vertical semi‐elliptical slot is inserted into ground and subsequently, an axis of semi‐ellipse is rotated diagonally (with 45°) in direction of the substrate. Axes of semi‐ellipse are optimized symmetrically around the circular patch to work antenna as a reflector. Furthermore, semi‐elliptical slot is rotated horizontally (with 90°) again to improve the impedance bandwidth. Proposed antenna achieves fractional bandwidth around 83% covering the UWB frequency range from 4.40 to 10.60 GHz (S11 < −10 dB) having 4.5/6/7/8/9.3/10.2 GHz resonant frequencies. Also, antenna is capable to send low‐distortion Gaussian pulses with fidelity factor more than 95% in time‐domain. Measured gain and half power beam width (HPBW) are 6.1‐9.1 dBi and 44°‐29° in 4.40‐10.60 GHz band, respectively, which show an improvement of 1‐3 dBi in gain and half power beam‐width is reduced by 5°‐10° when compared with previously designed antennas. Experimental results show good agreement with CST simulation.
Remotely delivered cognitive-behavioural and personalized exercise interventions to lessen the impact of fatigue: a qualitative evaluation

Abstract Objectives Fatigue can be a disabling symptom of inflammatory rheumatic diseases. LIFT (Lessening the Impact of Fatigue in inflammatory rheumatic diseases: a randomized Trial) is a randomized trial of remotely delivered cognitive-behavioural approach or personalized exercise programme interventions, compared with usual care. The aim of this nested qualitative study was to evaluate participants’ experiences of taking part in the intervention, including their ideas about future service delivery. Methods Semi-structured telephone interviews were conducted with a subgroup of LIFT participants to discuss their views and experiences of the interventions. Results Forty-three participants (30 women) from six sites who had participated in the cognitive-behavioural approach (n = 22) or personalized exercise programme (n = 21) interventions took part. Five themes were identified in the thematic analysis. In the theme ‘not a miracle cure, but a way to better manage fatigue’, LIFT could not cure fatigue; however, most felt better able to manage after participating. Participants valued ‘building a therapeutic relationship’ with the same therapist throughout the intervention. In ‘structure, self-monitoring and being accountable’, participants liked the inclusion of goal-setting techniques and were motivated by reporting back to the therapist. After taking part in the interventions, participants felt ‘better equipped to cope with fatigue’; more confident and empowered. Lastly, participants shared ideas for ‘a tailored programme delivered remotely’, including follow-up sessions, video calling, and group-based sessions for social support. Conclusion Many participants engaged with the LIFT interventions and reported benefits of taking part. This suggests an important future role for the remote delivery of fatigue self-management.
Output Power and Gain Monitoring in RF CMOS Class A Power Amplifiers by Thermal Imaging

The viability of using off-chip single-shot imaging techniques for local thermal testing in integrated radio frequency (RF) power amplifiers (PAs) is analyzed. With this approach, the frequency response of the output power and power gain of a Class A RF PA is measured, also deriving information about the intrinsic operation of its transistors. To carry out this paper, the PA is heterodynally driven, and its electrical behavior is down converted into a lower frequency thermal field acquirable with an InfraRed lock-in thermography (IR-LIT) system. After discussing the theory, the feasibility of the proposed approach is demonstrated and assessed with thermal sensors monolithically integrated in the PA. As crucial advantages to RF-testing, this local approach is noninvasive and demands less complex instrumentation than the mainstream commercially available solutions.
Compact Sets in the Space L~(O,

A characterization o] compact sets in L~(0, T; B) is given, where 1 B. Using the present characterization /or this kind o] situatious, su]]ieient conditions ]or compactness are given with optimal parameters. As an example, it is proved that i] {f~} is bounded in ~q(O, T; B) and in L~oo(O, T; X) and i] {~],/~t} is bounded in L~or T; Y) then {f. } is relatively compact in L~(O, T; B), Yp < q.
Asymptotics of the QMLE for General Arch(Q) Models

Asymptotic properties of the quasi-maximum likelihood estimator (QMLE) for general ARCH(q) models - including for example Power ARCH and log-ARCH - are derived. Strong consistency is established under the assumptions that the ARCH process is geometrically ergodic, the conditional variance function has a finite log-moment, and finite second moment of the rescaled error. We allow for a non-compact parameter space. Asymptotic normality of the estimator is established under the additional assumption that certain ratios involving the conditional variance function are suitably bounded, and that the rescaled errors have little more than fourth moment. We verify our general conditions for a range of specific ARCH models.
Lower Cambrian Organic-Rich Shales in Southern China: A Review of Gas-Bearing Property, Pore Structure, and Their Controlling Factors

The Lower Cambrian shales are widely developed in southern China, with greater thicknesses and higher TOC contents. Although the shale gas resource potential has been suggested to be huge, the shale gas exploration and development is not satisfactory. At present, the gas-bearing property evaluation of the Lower Cambrian shale is still a hot spot of concern. According to previous works, this paper systematically summarizes the gas-bearing characteristics and controlling factors of the Lower Cambrian shales in southern China. The buried depth of Lower Cambrian shales mainly ranges from 3000 m to 6000 m, and the thickness of organic-rich shale intervals ( TOC > 2 % ) varies from 20 m to 300 m. The TOC content and EqVRo value are generally up to 2%-10% and 2.5%-6.0%, respectively. The gas content of the Lower Cambrian shales in the Weiyuan-Qianwei block of the Sichuan Basin and the western Hubei area generally exceeds 2 m3/t, and gas composition is dominated by CH4. In southeastern Chongqing, northwestern Hunan, and northern Guizhou areas, the gas content of the Lower Cambrian shales is generally <2 m3/t, and the N2 content is generally >60%. In the Lower Yangtze region, the Lower Cambrian shale reservoirs basically contain no gas. Higher maturity, lower porosity, and less-no organic pores are suggested to be responsible for low gas contents and/or the predominate of N2 in shale gas reservoirs. Strong tectonic deformation is an important factor leading to the massive gas loss from shale reservoirs, thus resulting in no gas or only a small amount of N2 in the Lower Cambrian shales. In a word, the Lower Cambrian shale gas plays with low maturity and relatively stable tectonic condition, especially deep-ultradeep zones, may be the favorable targets for shale gas exploration.
Different teeth profile shapes of polymer gears and comparison of their performance

This article presents a lifespan testing analysis of polymer gears manufactured by cutting. Compared to injection molding, machine cutting provides higher accuracy of gear geometry. Two different tooth flank geometries were tested; i.e. involute and S-gears. In theory, S-gears have several advantages over involute gears due to the convex/concave contact between the matching flanks. The theoretical tooth flank geometry of S-gears provides more rolling and less sliding between the matching flanks, compared to involute gears. The convex/concave contact leads to lower contact stress, which in combination with less sliding means lower losses due to sliding friction and consequently less heat generated. The goal of our research was to prove that tooth flank geometry affects the lifetime of polymer gears, and to find the mechanisms and quantitative differences in the performance of both analyzed geometries. The gears were tested on specially designed testing equipment, which allows exact adjustment of the central axis distance. Two different material pairs (POM/POM and POM/PA66) of the drive and driven gears were tested. Each test was done at a constant moment load and a constant rotational speed. Several tests were conducted using the same conditions due to repeatability analysis. All the tests were performed till the failure of the gear pair and without lubrication. In lifespan testing, the polymer S-gears showed better performance and longer lifespan than involute polymer gears.
New Practical Nonlinear Energy-Harvesting Models for Wireless-Powered Communications

As a massive number of nodes are expected to be connected to each other in next-generation wireless networks, the power supply of such multiple-antenna nodes is a challenge and requires new and sustainable solutions. Radio frequency energy harvesting (EH) is among the promising approaches to solve this issue. In this paper, two new mathematically tractable nonlinear EH (NL-EH) models are proposed, for which the system performance is evaluated in terms of average harvested power, throughput, and bit error probability. The system consists of one multiantenna power-constraint source harvesting its power from a dedicated power beacon and transmitting its signal to a destination equipped with multiple antennas. For a comprehensive analysis of the system, closed-form expressions are derived for Nakagami- m fading channels and the special case of Rayleigh channels. For comparison purposes, the performance derivations in Nakagami- m fading channels are provided for linear and piece-wise linear EH models given in the literature. Besides, the simulation results are obtained by applying the Monte-Carlo method for NL-EH models existing in the literature. The results provide a broadening view of EH systems and thoroughly compare the proposed NL-EH models with linear, piece-wise linear, and NL-EH models available in the literature. Hence, these provide better insights towards the analyses and design of EH systems.
Radiofrequency Ablation as an Effective Long-Term Treatment for Chronic Sacroiliac Joint Pain: A Systematic Review of Randomized Controlled Trials

Radiofrequency ablation (RFA) has emerged as a popular intervention for chronic pain management, including pain originating in the sacroiliac joint. It offers a less invasive option than surgery but with better results than the previous standard treatment with steroid and anesthetic injections. Procedure volumes have enjoyed significant growth in the market in recent years. The evidence supporting this intervention, in the form of randomized controlled trials, however, is both thin and mixed. The purpose of this systematic review is to evaluate the body of randomized controlled trials (RCTs) to determine the quality of support for and against the use of radiofrequency ablation to treat sacroiliac joint (SIJ) pain. Several important new papers have emerged since previous systematic reviews with similar objectives were published. The review was conducted according to PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines, and three databases were used: PubMed, Google Scholar, and Scopus. Only RCTs were sought, and no other filters, such as a historical timeline cut-off, were used. Among 95 publications that returned in response to the query, 16 were ultimately accepted as meeting the inclusion/exclusion criteria. The Cochrane risk-of-bias tool was utilized as a quality assessment measure, and the GRADE (Grading of Recommendations, Assessment, Development, and Evaluations) framework was used to assess the certainty of the evidence. Among the included publications, 15 out of 16 publications featured positive results and conclusions that supported the use of RFA in treating chronic sacroiliac joint pain. The single negative study was also the largest trial (n=681), but it was identified as “High Risk” using the Cochrane risk-of-bias tool. It included several design flaws including neither operator nor patient blinding, missing information, use of inconsistent treatment modalities across groups, and disproportionate drop-out rates. Despite its flaws, we have included this study in the present review because of its sheer size. Taken in aggregate, the total body of research included in this review supports this intervention. Questions continue to exist around whether there are clinically significant benefits associated with different RFA modalities (for example, unipolar vs. bipolar), with convincing evidence supporting each of them. Finally, it can be concluded that while the benefits are reasonably and justifiably supported in this patient population for up to one year, there is a dearth of evidence beyond a 12-month post-intervention follow-up.
Evaluation of the impact of active signage on road user behaviour at pedestrian crossings

The main objective of the study was to verify the effectiveness of the active pedestrian crossings equipped with flashing lights activated automatically by detected pedestrians. Eight unsignalised pedestrian crossings were video-recorded for 48 hours each, both before and after installation of the equipment. An additional survey was done a month after the installation on three of the crossings. A traffic Conflict Rate was calculated for each crossing, as the number of conflicts per hour divided by the product of hourly pedestrian and vehicle traffic volume. The ANOVA test was used to check the statistical significance of changes of the indicators. The average percentage of drivers yielding to pedestrians increased by 94.8% and the average waiting time decreased by 39.2%. The Conflict Rate decreased at five out of eight sites. The average speeds of vehicles approaching the crossings decreased by 3.9 km/h. The “before-one month after” analysis mostly confirmed the positive results of the first analysis. Generally, at four out of eight crossings the effects were clearly positive, at two, relatively positive, and at the remaining two there was no clear positive effect. These sites were multilane streets which suggests that such sites should be either signalised or narrowed.