Miracle-dz/UniFAR-FTUs huggingface dataset:
Profiling of cell‐free DNA methylation and histone signatures in pediatric NAFLD: A pilot study

Nonalcoholic fatty liver disease (NAFLD) has become the most common chronic liver disease in children and adolescents, increasing the risk of its progression toward nonalcoholic steatohepatitis (NASH), cirrhosis, and cancer. There is an urgent need for noninvasive early diagnostic and prognostic tools such as epigenetic marks (epimarks), which would replace liver biopsy in the future. We used plasma samples from 67 children with biopsy‐proven NAFLD, and as controls we used samples from 20 children negative for steatosis by ultrasound. All patients were genotyped for patatin‐like phospholipase domain containing 3 (PNPLA3), transmembrane 6 superfamily member 2 (TM6SF2), membrane bound O‐acyltransferase domain containing 7 (MBOAT7), and klotho‐β (KLB) gene variants, and data on anthropometric and biochemical parameters were collected. Furthermore, plasma cell‐free DNA (cfDNA) methylation was quantified using a commercially available kit, and ImageStream(X) was used for the detection of free circulating histone complexes and variants. We found a significant enrichment of the levels of histone macroH2A1.2 in the plasma of children with NAFLD compared to controls, and a strong correlation between cfDNA methylation levels and NASH. Receiver operating characteristic curve analysis demonstrated that combination of cfDNA methylation, PNPLA3 rs738409 variant, coupled with either high‐density lipoprotein cholesterol or alanine aminotransferase levels can strongly predict the progression of pediatric NAFLD to NASH with area under the curve >0.87. Conclusion: Our pilot study combined epimarks and genetic and metabolic markers for a robust risk assessment of NAFLD development and progression in children, offering a promising noninvasive tool for the consistent diagnosis and prognosis of pediatric NAFLD. Further studies are necessary to identify their pathogenic origin and function.
USP7 Induces Chemoresistance in Triple-Negative Breast Cancer via Deubiquitination and Stabilization of ABCB1

Triple-negative breast cancer (TNBC) accounts for 15–20% of all breast cancer. TNBC does not express the estrogen receptor, progesterone receptor, or human epidermal growth factor receptor 2. Cytotoxic chemotherapy and surgery are the current therapeutic strategies for TNBC patients, but the chemoresistance of TNBC limits the efficiency of this strategy and shortens the lifespan of patients. The exploration of targeted therapy is ongoing in TNBC research. The aim of the present study was to identify the mechanism underlying acquired resistance in TNBC through the exploration of the relationship between the expression of USP7 and of ABCB1. We found that ubiquitin specific protease 7 (USP7) is a potential therapeutic target for overcoming the chemoresistance of TNBC. USP7 overexpression increased the chemoresistance of TNBC, while the knockdown of USP7 effectively increased the chemosensitivity of chemoresistant TNBC. A USP7 inhibitor effectively induced apoptosis and suppressed metastasis in chemoresistant TNBC. We further clarified that USP7 is a specific deubiquitinating enzyme for ABCB1 that plays an essential role in drug resistance. USP7 directly interacted with ABCB1 and regulated its stability. We concluded that USP7 promotes the chemoresistance of TNBC by stabilizing the ABCB1 protein.
DISCOVERY OF A NEW FAINT DWARF GALAXY ASSOCIATED WITH NGC 253

We report the discovery of a new faint dwarf galaxy, which we dub Scl-MM-Dw1, at a projected distance of ∼65 kpc from the spiral galaxy NGC 253. The discovery results from the Panoramic Imaging Survey of Centaurus and Sculptor (PISCeS), a program with the Magellan/Megacam imager to study faint substructure in resolved stellar light around massive galaxies outside of the Local Group. We measure a tip of the red giant branch distance to Scl-MM-Dw1 of D = 3.9 ± 0.5 Mpc, consistent with that of NGC 253, making their association likely. The new dwarf's stellar population is complex, with an old, metal-poor red giant branch (≳10 Gyr, [Fe/H] ∼ −2), and an asymptotic giant branch with an age of ∼500 Myr. Scl-MM-Dw1 has a half-light radius of rh = 340 ± 50 pc and an absolute magnitude of MV = −10.3 ± 0.6 mag, comparable to the Milky Way's satellites at the same luminosity. Once complete, our imaging survey of NGC 253 and other nearby massive galaxies will provide a census of faint substructure in halos beyond the Local Group, both to put our own environment into context and to confront models of hierarchical structure formation.
Secondary School Students’ Well-Being as an Effect of Outdoor Physical Activity versus Indoor Activity and Inactivity

(1) Background: Well-being is a broad concept within which, among other components, self-esteem and general mood can be distinguished. Their formation can take place on the basis of contact with physical activity and with the natural environment. (2) Methods: The aim of the study was to compare the self-esteem and general mood of schoolchildren at different levels of contact with physical activity and the natural environment, distinguishing between active outdoor, active indoor and inactive groups. The study involved 306 secondary school students aged 16–19 years. The study used a diagnostic survey method, choosing a questionnaire technique. Two research tools in the form of survey questionnaires were used: Rosenberg Self-Esteem Scale—SES and General Mood Scale—GMS. (3) Results: The results indicated physical activity as an important determinant of both well-being components studied. In the study group of adolescents, contact with the natural environment proved to be a non-significant determinant of well-being. (4) Conclusions: The hypothesis of a synergistic positive effect of physical activity and contact with nature on self-esteem and general mood, which was not confirmed in this study, should be verified among representatives of older age groups.
Optical scatter of quantum noise filter cavity optics

Optical cavities to filter squeezed light for quantum noise reduction require optics with very low scattering losses. We report on measured light scattering from two super-polished fused silica optics before and after applying highly-reflective ion-beam sputtered dielectric coatings. We used an imaging scatterometer that illuminates the sample with a linearly polarized 1064 nm wavelength laser at a fixed angle of incidence and records images of back scatter for azimuthal angles in the plane of the laser beam. We extract from these images the bidirectional reflectance distribution function (BRDF) of the optics with and without coating and estimate their integrated scatter. We find that application of these coatings led to a more than 50% increase of the integrated wide-angle scatter, to 5.00 ± 0.30 ? > and 3.38 ± 0.20 ? > ppm for the two coated samples. In addition, the BRDF function of the coated optics takes on a pattern of maxima versus azimuthal angle. We compare with a scattering model to show that this is qualitatively consistent with roughness scattering from the coating layer interfaces. These results are part of a broader study to understand and minimize optical loss in quantum noise filter cavities for interferometric gravitational-wave detectors. The scattering measured for these samples is acceptable for the 16 m long filter cavities envisioned for the Laser Interferometer Gravitational-wave Observatory (LIGO), though reducing the loss further would improve LIGO’s quantum-noise limited performance.
Nexus Between Financial Crises, Corporate Governance and Future Stock Price Crash Risk

We aim to investigate the impact of corporate governance attributes on future stock price crash risk in stable and crisis periods. We used Dynamic Panel Generalized Method of Movements (DPGMM) and Principal Component Analysis (PCA) to generate the factors for the individual attribute to capture the accuracy of the results. Ownership concentration and board structure have a significant negative while audit quality has no association with the stock price crash risk. However, the financial crisis has a positive association with stock crash risk. Furthermore, the study provides a potential screening methodology for investors to mitigate future risk as to price crash risk for portfolios that cannot be dealt with diversification.
Cepheids in open clusters: an 8D all-sky census

Cepheids in open clusters (cluster Cepheids: CCs) are of great importance as zeropoint calibrators of the Galactic Cepheid period-luminosity relationship (PLR). We perform an 8-dimensional all-sky census that aims to identify new bona-fide CCs and provide a ranking of membership confidence for known CC candidates according to membership probabilities. The probabilities are computed for combinations of known Galactic open clusters and classical Cepheid candidates, based on spatial, kinematic, and population-specific membership constraints. Data employed in this analysis are taken largely from published literature and supplemented by a year-round observing program on both hemispheres dedicated to determining systemic radial velocities of Cepheids. In total, we find 23 bona-fide CCs, 5 of which are candidates identified for the first time, including an overtone-Cepheid member in NGC129. We discuss a subset of CC candidates in detail, some of which have been previously mentioned in the literature. Our results indicate unlikely membership for 7 Cepheids that have been previously discussed in terms of cluster membership. We furthermore revisit the Galactic PLR using our bona fide CC sample and obtain a result consistent with the recent calibration by Turner (2010). However, our calibration remains limited mainly by cluster uncertainties and the small number of long-period calibrators. In the near future, Gaia will enable our study to be carried out in much greater detail and accuracy, thanks to data homogeneity and greater levels of completeness.
Celiac Disease and Gallbladder: Pathophysiological Aspects and Clinical Issues

Background: Celiac Disease (CD) is an immune-mediated disorder which primarily affects the small intestine; however, extra-intestinal organs are often affected by the pathological process, too. As regards the digestive system, liver alterations in CD patients have been widely described, which can also extend to the biliary tract. Notably, gallbladder function can be altered in CD patients. In this review, we specifically analyze and summarize the main pathophysiological aspects and clinical evidence of gallbladder dysfunction in CD patients, in order to discuss the potential medical complications and clinical research gaps. In addition to some perturbations of bile composition, CD patients can develop gallbladder dysmotility, which mainly expresses with an impaired emptying during the digestive phase. The main pathophysiological determinant is a perturbation of cholecystokinin secretion by the specific duodenal enteroendocrine cells in response to the appropriate nutrient stimulation in CD patients. This situation appears to be reversible with a gluten-free diet in most cases. Despite this gallbladder impairment, CD patients do not seem to be more predisposed to gallbladder complications, such as calculous and acalculous cholecystitis. However, very few clinical studies have actively investigated these clinical aspects, which may not be completely evidenced so far; alternatively, the substantial improvements in the last two decades regarding CD diagnosis, which have reduced the diagnostic delay (and related dietary treatment), may have lessened the potential clinical consequences of CD-related gallbladder dysfunction. Specific clinical studies focused on these aspects are needed for a better understanding of the clinical implications of gallbladder alterations in CD patients.
A Molecular Disk around the Episodic Jets in KjPn 8

We report the detection of millimeter CO emission from a dense, expanding disk of molecular gas, ≈ 20'' in diameter, at the center of the remarkable 14' × 4', bipolar, episodic jet system of the planetary nebula KjPn 8. The disk surrounds the compact photoionized core and exceeds it in mass by at least an order of magnitude. The disk axis lies at a position angle of ≈ 115° and appears to be aligned with the most prominent and youngest of the bipolar jets. The disk axis is not, however, aligned with the older, more extensive bipolar structure of the nebula at a position angle of ≈ 71°, indicating that major changes have taken place in the escape of matter from the central star system over the last ≈ 5000 yr.
Transport relaxation time and length scales in turbulent suspensions

We show that in a turbulent flow transporting suspended sediment, the unsaturated sediment flux q(x, t) can be described by a first-order relaxation equation. From a mode analysis of the advection–diffusion equation for the particle concentration, the relaxation length and time scales of the dominant mode are shown to be the deposition length HU/Vfall and deposition time H/Vfall, where H is the flow depth, U the mean flow velocity and Vfall the sediment settling velocity. This result is expected to be particularly relevant for the case of sediment transport in slowly varying flows, where the flux is never far from saturation. Predictions are shown to be in quantitative agreement with flume experiments, for both net erosion and net deposition situations.
Novel Method of Oil/Water Separation Using Composite of Polymethylacrylamide Hydrogel-Coated Metal Mesh

Different compositions of hydrogels composed of mathacrylamide homopolymer (60 and 90% of PMAM) were prepared using the free radical polymerization technique, with and without methylene bisacrylamide as crosslinker (0 and 3%). Several parameters and properties were studied to evaluate their performance as oil/water separators. Many parameters are used, such as residual oil in water, water recovery, separation time, hydrogels coated percentages, swelling parameters, mechanical properties, microscopic and photographic images, and scanning electron microscopy. The results showed that water recovery (87-97), Separation efficiency (96.2-99.6 %), separation time (6-9.5 min.), hydrogels coated percentages (18-23 %), water content (70-97 %), and tensile test (63-90 MPa). The effect of polymer crosslinking density, mesh pore size, and polymer composition on the parameters and properties mentioned above were also studied. The results showed that the separation efficiency of 1000 micron mesh composite is better than 500-micron mesh composites.
Protecting the Skies: GNSS-less Aircraft Navigation with Terrestrial Cellular Signals of Opportunity

This paper shows how to protect our skies from harmful radio frequency interference (RFI) to global navigation satellite system (GNSS) signals, by offering terrestrial cellular signals of opportunity (SOPs) as a viable aircraft navigation system backup. An extensive flight campaign was conducted by the Autonomous Systems Perception, Intelligence, and Navigation (ASPIN) Laboratory in collaboration with the United States Air Force (USAF) to study the potential of cellular SOPs for high-altitude aircraft navigation. A multitude of flight trajectories and altitudes were exercised in the flight campaign in two different regions in Southern California, USA: (i) rural and (ii) semi-urban. Samples of the ambient downlink cellular SOPs were recorded, which were fed to ASPIN Laboratory’s MATRIX (Multichannel Adaptive TRansceiver Information eXtractor) software-defined receiver (SDR), which produced carrier phase measurements from these samples. These measurements were fused with altimeter data via an extended Kalman filter (EKF) to estimate the aircraft’s trajectory. This paper shows for the first time that at altitudes as high as about 11,000 ft above ground level (AGL), more than 100 cellular long-term evolution (LTE) eNodeBs can be reliable tracked, many of which were more than 100 km away, with carrier-to-noise ratio ( C/N 0 ) exceeding 40 dB-Hz. The paper shows pseudorange and Doppler tracking results from cellular eNodeBs along with the C/N 0 and number of tracked eNodeBs over the two regions, while performing ascending, descending, and grid maneuvers. In addition, the paper shows navigation results in the rural and semi-urban regions, showing a position root mean-squared error of 9.86 m and 10.37, respectively, over trajectories of 42.23 km and 56.56 km, respectively, while exploiting an average of about 19 and 10 eNodeBs, respectively.
Characteristics of Respiratory Syncytial Virus versus Influenza Infection in Hospitalized Patients of Peru: A Retrospective Observational Study

Respiratory syncytial virus (RSV) and influenza infections are important causes of respiratory illness associated with hospitalizations in children in Peru; however, comparisons of RSV and influenza hospitalization across all age groups are not available in Peru. Therefore, we conducted an observational, retrospective study between May 2015 and October 2021 using hospitalization from RSV and influenza infection data obtained from SUSALUD (open data) in Peru to compare the baseline characteristics of sex, age, region, and infection type. For the study, 2696 RSV-infected and 1563 influenza-infected hospitalized patients from different age groups were included. Most hospitalizations from RSV infection and the influenza virus occurred in children <5 years of age (86.1% vs. 32.2%, respectively). Compared with influenza infection, RSV infection was less likely to occur in individuals ≥5 years of age (adjusted odds ratio (aOR) = 0.07; 95% confidence interval (CI), 0.06–0.08; p < 0.0001; compared to <5 years of age), and more likely to occur in highlands (aOR = 1.75; 95% CI, 1.46–2.07; p < 0.0001, compared to coast region), and jungle region (aOR = 1.75; 95% CI, 1.27–2.41; p = 0.001, compared to coast region). Among the respiratory complications, RSV pneumonia was less likely to occur between different age groups (aOR = 0.29; 95% CI, 0.22–0.37; p < 0.0001, compared to <5 years of age), compared with influenza pneumonia. These findings on the RSV-hospitalization and its complications are helpful for health services planning and may increase awareness of the Peruvian population’s RSV and influenza disease burden.
ROTATIONAL CORRECTIONS TO NEUTRON-STAR RADIUS MEASUREMENTS FROM THERMAL SPECTRA

We calculate the rotational broadening in the observed thermal spectra of neutron stars spinning at moderate rates in the Hartle–Thorne approximation. These calculations accurately account for the effects of the second-order Doppler boosts as well as for the oblate shapes and the quadrupole moments of the neutron stars. We find that fitting the spectra and inferring the bolometric fluxes under the assumption that a star is not rotating causes an underestimate of the inferred fluxes and, thus, radii. The correction depends on the stellar spin, mass, radius, and the observer's inclination. For a 10 km, 1.4 M☉ neutron star spinning at 600 Hz, the rotational correction to the flux is ∼1%–4%, while for a 15 km neutron star with the same spin period, the correction ranges from 2% for pole-on sources to 12% for edge-on sources. We calculate the inclination-averaged corrections to inferred radii as a function of the neutron-star radius and mass and provide an empirical formula for the corrections. For realistic neutron-star parameters (1.4 M☉, 12 km, 600 Hz), the stellar radius is on the order of 4% larger than the radius inferred under the assumption that the star is not spinning.
ON THE DISTANCE OF THE GLOBULAR CLUSTER M4 (NGC 6121) USING RR LYRAE STARS. I. OPTICAL AND NEAR-INFRARED PERIOD–LUMINOSITY AND PERIOD–WESENHEIT RELATIONS

We present new distance determinations to the nearby globular M4 (NGC 6121) based on accurate optical and near-infrared (NIR) mean magnitudes for fundamental (FU) and first overtone (FO) RR Lyrae variables (RRLs), and new empirical optical and NIR period–luminosity (PL) and period–Wesenheit (PW) relations. We have found that optical–NIR and NIR PL and PW relations are affected by smaller standard deviations than optical relations. The difference is the consequence of a steady decrease in the intrinsic spread of cluster RRL apparent magnitudes at fixed period as longer wavelengths are considered. The weighted mean visual apparent magnitude of 44 cluster RRLs is =13.329 ± 0.001 (standard error of the mean) ±0.177 (weighted standard deviation) mag. Distances were estimated using RR Lyr itself to fix the zero-point of the empirical PL and PW relations. Using the entire sample (FU+FO) we found weighted mean true distance moduli of 11.35 ± 0.03 ± 0.05 mag and 11.32 ± 0.02 ± 0.07 mag. Distances were also evaluated using predicted metallicity dependent PLZ and PWZ relations. We found weighted mean true distance moduli of 11.283 ± 0.010 ± 0.018 mag (NIR PLZ) and 11.272 ± 0.005 ± 0.019 mag (optical–NIR and NIR PWZ). The above weighted mean true distance moduli agree within 1σ. The same result is found from distances based on PWZ relations in which the color index is independent of the adopted magnitude (11.272 ± 0.004 ± 0.013 mag). These distances agree quite well with the geometric distance provided by Kaluzny et al. based on three eclipsing binaries. The available evidence indicates that this approach can provide distances to globulars hosting RRLs with a precision better than 2%–3%.
Adapted work placement delivery method under COVID-19 towards students’ job preparatory behaviours

This study investigated students’ perceptions of an adapted work placement (WP) delivery method due to COVID-19, their intention of finding paid jobs or becoming self-employed and how the intention influenced their job preparatory behaviours (JPB). Ajzen’s Theory of Planned Behaviour (TPB) was utilised as a theoretical framework to model the research design. The TPB framework has three constructs – attitude towards behaviour, subjective norm and perceived behavioural control – that lead to students’ intentions with regard to future jobs and, ultimately, behaviours. The study analysed three sets of data from: (i) semi-structured interviews with accounting students, (ii) a semi-structured interview with the head of an accounting department, (iii) document analysis of a WP guidebook. All data were collected from a polytechnic in Indonesia. There were three key findings. In terms of students’ perceptions, the adapted WP programme created disappointment among the students. Beyond this disappointment, the adapted delivery method unexpectedly increased the students’ self-employment intentions. Nonetheless, the intentions did not entirely prompt the students to pursue JPB towards self-employment. This paper provides insights into how higher education institutions might restructure their WP programmes, especially in times of crisis, and provides suggestions for students’ job preparations.
The Hubble Space Telescope UV Legacy Survey of Galactic Globular Clusters - IV. Helium content and relative age of multiple stellar populations within NGC 6352

In this paper we combine WFC3/UVIS F275W, F336W, and F438W data from the “UV Legacy Survey of Galactic Globular Clusters: Shedding Light on Their Populations and Formation” (GO 13297) HST Treasury program with F606W, F625W, F658N, and F814W ACS archive data for a multi-wavelength study of the globular cluster NGC 6352. In the colormagnitude and two-color diagrams obtained with appropriate combination of the photometry in the different bands we separate two distinct stellar populations an d trace them from the main sequence to the subgiant, red giant, horizontal and asymptotic giant branches.