Miracle-dz/UniFAR-FTUs huggingface dataset:
CLINICAL EVALUATION OF PULPOTOMY OF PRIMARY MOLARS APPLYING PROPOLIS VERSUS FORMOCRESOL

Aim: The purpose of this study was to clinically evaluate applying propolis versus formocresol as a pulpotomy material in exposed primary molars. Methods: This study included 60 primary molars in 60 children 4–9 years of age who underwent an identical conventional pulpotomy technique; the molars were allocated to propolis, Formocresol groups. The patients were recalled after an interval of 1 monthand 3 months for clinical and radiographic evaluation. Results : The clinical success rates according to presence or absence of pain swelling sensitivity to percussion for propolis group were 93%, 100%, 100% respectively after 1 month and 90%, 93%, 96% after 3 months and for fc group it was 96%, 100%, 100%after 1 month and 93%, 96%, 96% after 3 months which indicates that there was no significant difference between the two materials. And for radiographic examination therewasno significant difference between the two materials at one month, three months intervals regarding root resorption and periapical radiolucency Conclusions : it could be concluded that propolis offers good clinical and radiographical results when compared with formocresol, but with no statistically significant differences
In vitro screening of putative probiotic strains and prebiotics for effective anti diarrheal synbiotics formulation

2018 Abstract: The present study was to investigate the utilization of prebiotics by selected Lactobacillus and Bifidobacterium probiotic strains and antagonistic effect of their potential synergy on enterotoxigenic Escherichia coli ( ETEC ) as target pathogen . To select the suitable synbiotic combination, in vitro fermentation, antibacterial potential through co - culturing, and toxin production by ETEC in co - cultured condition through GM1 enzyme - linked immunosorbent assay ( GM1 - ELISA ) was undertaken . All putative probiotic strains grew well in basal media supplemented with fructooligosaccharides ( FOS ) and galactooligosaccharides ( GOS ) , whereas greater inactivation of ETEC was observed when FOS was used with L . rhamnosus RSI3, GOS with Bifidobacterium breve BIF7 and inulin with Lactobacillus acidophilus NCDC 13 . All three combinations shown greater than two log reduction in ETEC population . Also, there was a decrease in LT enterotoxin concentration when ETEC was grown with these synbiotics . Short chain FOS, GOS and inulin was found to be the most effective substrates, depending on its compatibility with different strains improving its antagonistic activity for the development of antidiarrheal synbiotics . These pairs can be used as synbiotic combinations for preparing dairy based fermented formulations against secretory diarrhea
A DFT study on Electronic Excitations, Charge Transfer and NLO Properties of Visible Absorbing Squaraine and Thiosquaraine dyes

Density functional calculations have been performed to see the effect of sulfur substitution in place of oxygen at central four membered acceptor squarate ring on electronic excitations, charge transfer and second order non-linear optical properties in visible absorbing squaraines (SQ). Molecules oxy-thiosquaraines (OSQ) and thiosquaraines (SSQ) have shown red shift in absorption as compared to their corresponding SQ molecules. The lowest five electronic excitations for all the molecules have been calculated by using TDDFT method. Further, effect of electron donating and electron withdrawing groups on absorption maxima have been studied. The large red shifts in case of electron withdrawing group within the same series of molecules (SQ, OSQ and SSQ) are due to destabilization of HOMO and stabilization of LUMO levels. Charge transfers in these molecules are reported by using VMOdes. Second hyperpolarizabilities (  γ  ) for these molecules are calculated by SOS method. This study may be helpful in synthesizing new C-N bonding SQ, OSQ and SSQ dyes which are further useful in
HYPOGLYCEMIC AND HYPOLIPIDEMIC EFFECT OF METHONOLIC SEED EXTRACT OF EMBELIA ROBUSTA IN ALLOXAN INDUCED DYSLIPIDEMIA IN WISTAR RATS

Ayurveda refers Embelia robusta (Sanskrit: Tandula ) as a medicinal plant used for the treatment of diabetes mellitus, anticancer, antiinflammatory, antifungal, antibacterial. Objective: The present study was carried out to evaluate the hypolipidemic activity of methonolic seed extract of E.robusta in normal and Alloxan induced diabetic dyslipidemic rats. Method: Diabetes was induced in male wistar rats by single intraperitonial injection of Alloxan (130mg/kg) body weight. After diabetic induction methanolic seed extract of E.robusta at the dose 50mg/kg (T1) and 100mg/kg (T2) body weight was used as a test drug and Gliclazide 50mg/kg body weight as a standard drug to the diabetes induced experimental rats for 30days. Acute toxicity and Oral glucose tolerance study was carried out in normal rats, Activity of methonolic seed extract of E.robusta on lipid profile was carried on diabetes induced rats, which showed significant reduction in lipid parameters in both Test group T1 & Test group T2. Result : Acute toxicity study showed no signs of toxicity by methanolic seed extract of E.robusta even when the dose was increased to 4000mg/kg body weight. In oral glucose tolerance test rats treated with methanolic seed extract of E.robusta at the dose T2 showed significant (P<0.05) reduction in hyperglycaemic control in Group-IV and there was significant reduction in serum level TC (116.3), TG (108.7), LDL (36.43), VLDL (21.7) and increases in level of HDL (58.17), comparable to the standard control. Conclusion: The results indicate that methonolic seed extract of E.robusta has hypoglycemic and hypolipidemic activity.
The Contribution of Coping Resources to the Success in Weight Reduction

In recent years, obesity is viewed as an epidemic in Israel. This study examines the contribution of coping resources to exceptional success in weight reduction and the adoption of healthy behaviors, to trace the implications of this success and to shed light on its significance in personal and professional- educational arenas. The theoretical framework was the positive psychology approach and success analysis. The sample included student teachers, and information was gathered through in-depth interviews. Analysis revealed the contribution of personal inner resources and social external resources to weight reduction and the adoption of healthy behaviors. Moreover, it emerged that the participants experienced personal growth, which expressed itself in a generalization of the strengths and resources they acquired through weight reduction and their application to academic work and teaching. All these contributed to their mental wellbeing and quality of life. The unique contribution is the identification of mechanisms that contribute to the actualization of resources for behaviors that actually promote health, and the understanding of the potential for change in weight reduction to optimize adaptive functioning systems. The study has practical importance for developing educational approaches to promote health and mental wellbeing among educators.
Functional Immune Responses Impairing Lymphorganogenesis or Suppresses Bone Resorption without Osteoprotegerin Transgenic Mice and Rats Continuous RANKL Inhibition in

Receptor activator of NF- (cid:1) B ligand (RANKL) is an essential mediator of osteoclast formation, function, and survival. The effects of RANKL are inhibited by a soluble decoy receptor called osteoprotegerin (OPG). Total ablation of RANKL in knockout mice leads to high bone mass, lymph node agenesis, and altered lymphocyte differentiation. In contrast, RANKL inhibition via OPG suppresses bone resorption but not inﬂammation in animal models of inﬂammatory bone loss. This suggests that the immune phenotype of RANKL knockout mice is related to total RANKL ablation. We hypothesized that prenatal RANKL inhibition via OPG overexpression would suppress bone resorption without inﬂuencing lymph node formation or subsequent immune responses. Transgenic rats were created, wherein soluble OPG was overexpressed by 100-fold vs wild type (WT) controls, by gestational day 11 (i.e., before lymph node formation). The structure of lymph nodes, spleen, and thymus of OPG-transgenic (OPG-Tg) animals were comparable to those of age-matched WT rats at gestational day 19 and in adulthood. The OPG-Tg neonates had elevated bone mass, conﬁrming the prenatal inhibition of RANKL. Adult OPG-Tg rats and OPG-Tg mice exhibited no signiﬁcant functional alterations relative to WT controls when subjected to immune challenges to test for altered innate and humoral responses (e.g., contact hypersensitivity to oxazolone, IgM response to Pneumovax, IgG response to keyhole limpet hemocyanin, splenic B lymphocytes). These data indicate that splenic T and B lymphocytes from OPG-Tg rodents and their WT littermates re-sponded similarly to T and B cell-speciﬁc polyclonal activators anti-CD3 and anti-IgM.
University Assessment of the T-SPOT.CMV interferon- release assay in renal transplant recipients: A single center cohort study

Background The measurement of CMV specific cellular immunity in organ transplant recipients could contribute additional acuity to serology based, CMV infection risk stratification, facilitating optimisation of immunosuppression and anti-viral prophylaxis. Methods A pilot study of renal transplant recipient (RTR’s) responses in the T-SPOT.CMV ELISPOT based assay. 108 RTR’s were recruited 3 months post-transplantation, immediately prior to the cessation of stratified anti-viral prophylaxis, used in recipients from seropositive donors. RTR’s were monitored for CMV viremia and disease. Cellular responses to peptides derived from CMV IE1 and pp65 were measured, using the T-SPOT.CMV assay. Results At recruitment, no CMV specific cellular immunity was detected by T-SPOT.CMV in CMV seronegative recipients (IE1 (cid:20) 1spot / 2.5x10 5 PBMC’s; pp65 (cid:20) 3 spots / 2.5x10 5 PBMC’s). At recruitment, CMV sero-positive recipients who made a robust response to both IE1 ( > 25 spots / 2.5x10 5 PBMC’s) and pp65 ( > 50 spots / 2.5x10 5 PBMC’s), were less likely to develop high level viremia than those who responded to one or neither antigen (0/28 vs 5/25; p < 0.02). assessing the diversity of response to CMV antigens, may enhance risk stratification in this group.
CMAR_A_253042 6103..6112

Di-Er Sun Shu-Yuan Ye 1,2 1Clinical Laboratory, HwaMei Hospital, University of Chinese Academy of Sciences, Ningbo, Zhejiang, People’s Republic of China; 2Clinical Laboratory, Ningbo Institute of Life and Health Industry, University of Chinese Academy of Sciences, Ningbo, Zhejiang, People’s Republic of China Abstract: Despite numerous advances in cancer treatment, the global prevalence and cancer-related mortality remain high. Understanding tumor initiation and progression mechanisms are critical as it will lead to the development of interventions for improving the prognosis of cancer patients. The roles of long noncoding RNAs (lncRNAs) in cancer have attracted immense research interest. Growing evidence indicates that lncRNA regulator of reprogramming (linc-ROR), a well-studied RNA, regulates the progression of various cancers, such as lung cancer (LC), hepatocellular carcinoma (HCC), breast cancer (BC), colorectal cancer (CRC), pancreatic cancer (PC), papillary thyroid carcinoma (PTC), or esophageal squamous cell carcinoma (ESCC). linc-ROR promotes the proliferation, invasion, migration and chemoresistance of cancer cells. Herein, we reviewed current literature on the modulatory functions and mechanisms of linc-ROR in cancer development. We highlight new linc-ROR-related therapeutic strategies in cancer treatment.
Assessing the Relatedness of Abelmoschus Accessions using Morphological Characters

Character analysis of Okra ( Abelmoschus [Medik.] species, Malvaceae) accessions was carried out using morphological data to evaluate their genetic distinction and relatedness. Seeds of five Abelmoschus accessions (NG/MR/01/10/002, A.E 3, NG/MR/MAY/09/009, NGAE-96-0065 and NG/OA/05/12/160) were obtained from the Gene Bank of National Centre for Genetic Resources and Biotechnology, Ibadan, Nigeria. Based on the International Board for Plant Genetic Resources standard descriptors for Okra, 16 qualitative morphological characters were selected based on their relevance to Abelmoschus breeding, crop distinction, utilization and conservation. The five accessions present significant differences with two of the accessions (NG/MR/MAY/09/009 and NG/OA/05/12/160) closely related and other three (NG/MR/01/10/002, A.E 3 and NGAE-96-0065) closely related too. Accessions NG/MR/01/10/002, A.E 3 and NGAE-96-0065 had medium or intermediate growth habit while accession NG/MR/MAY/09/009 and NG/OA/05/12/160 shows erect growth habit. General aspect of the stem, nature of branching, fruit pubescence, fruit shape, position of the fruit on the main stem, leaf shape, fruit colour, and fruit length at maturity had the most effect on observed relationship between the accessions. Scatter plots derived from the principal component analysis suggest moderate tendency of grouping with the genus where two distinct clusters were obtained from the dendrogram. Together, these results suggest that the five okra accessions may be the descendants of the two commonly cultivated Abelmoschus species in Southern Nigeria (i.e. A . esculentus and A . caillei ).
Specialized color modules in macaque extrastriate brain

It is unclear how the brain determines hue. Imaging studies are consistent with the existence of specialized color regions in the brain, but electrophysiological studies have produced conflicting results. Here we address the neural basis for color, using targeted single-unit recording in alert macaque monkeys, guided by functional magnetic resonance imaging (fMRI) of the same subjects. Distributed within posterior inferior temporal cortex, a large region encompassing V4, PITd and posterior TEO that some have proposed functions as a single visual complex, we found color-biased fMRI hotspots, which we call “globs”, each several millimeters wide. Almost all cells located in the globs showed strong luminance-invariant color tuning, and some shape selectivity; cells in different globs represented distinct visual field locations, consistent with the coarse retinotopy of this brain region. Cells in “inter-glob” regions were not color-tuned, but more strongly shape-selective. Neither population was direction-selective. These results argue that color perception is mediated by specialized neurons that are clustered within the extrastriate brain.
DMSO_A_305919 1975..1985

1Department of Nephrology, The Second Clinical Medical Institution of North Sichuan Medical College (Nanchong Central Hospital) and Nanchong Key Laboratory of Basic Science & Clinical Research on Chronic Kidney Disease, Nanchong, Sichuan, People’s Republic of China; 2Department of Nephrology, Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, People’s Republic of China
Wave propagation across non-linear rock joints based on time-domain recursive method

I e i s m l Studying wave propagation across joints is crucial in geophysics, mining and underground construction. Limited analyses are available for oblique incidence across non-linear joints. In this paper, the time-domain recursive method (TDRM) proposed by Li et al. is extended to analyse wave propagation across a set of non-linear joints. The Barton–Bandis model (B–B model) and the Coulomb-slip model are adopted to describe the non-linear normal and shear properties of the joints, respectively. With the displacement discontinuity model and the time shifting function, the wave propagation equation is established for incident longitudinal-( P -) or transverse-( S -)wave across the joints with arbitrary impinging angles. Comparison between the results from the TDRM and the existing methods is carried out for two speciﬁc cases to verify the derived wave propagation equation. The effects of some parameters, such as the incident angle, the joint spacing, the amplitude of incidence and the joint maximum allowable normal closure, on wave propagation are discussed.
IS TOOTH HELPFUL IN IDENTIFICATION OF GENDER, AGE, AND BLOOD GROUP?

Introduction : Data in the form of age, gender, and blood group might provide vital clues in human identity through odontological examinations. Therefore it is important to gather as much data as possible using less tissue. The purpose of this study was to find out whether a tooth helpful in determine age, gender and ABO blood group of individual or not? Materials and Methods : The study sample consisted of twenty eight teeth divided into four groups under different environmental conditions and time. The teeth were sectioned longitudinally in the buccolingual plane along the midline. Longitudinal ground sections of each tooth were prepared for age determination from cemental lines. Pulp removed was divided into two halves thereafter sex and blood group was determined. Results : A strong positive correlation was found between the estimated age and actual age of the study groups. Moreover, there was no significant difference between the actual and determined sex and blood group of the study groups. Conclusion : Although age, sex, and blood group are more reliably determined in freshly extracted teeth, these variables may be of significant help in identification even after a period of 6 weeks post-extraction.
Kinase, and ApoptosisB, c-Jun N-Terminal k Activation of NF-Silymarin Suppresses TNF-Induced

2 Silymarin is a polyphenolic ﬂavonoid derived from milk thistle ( Silybum marianum ) that has anti-inﬂammatory, cytoprotective, and anticarcinogenic effects. How silymarin produces these effects is not understood, but it may involve suppression of NF- k B, a nuclear transcription factor, which regulates the expression of various genes involved in inﬂammation, cytoprotection, and carcinogenesis. In this report, we investigated the effect of silymarin on NF- k B activation induced by various inﬂammatory agents. Silymarin blocked TNF-induced activation of NF- k B in a dose- and time-dependent manner. This effect was mediated through inhibition of phosphorylation and degradation of Ik B a , an inhibitor of NF- k B. Silymarin blocked the translocation of p65 to the nucleus without affecting its ability to bind to the DNA. NF- k B-dependent reporter gene transcription was also suppressed by silymarin. Silymarin also blocked NF- k B activation induced by phorbol ester, LPS, okadaic acid, and ceramide, whereas H 2 O 2 induced NF- k B activation was not signiﬁcantly affected. The effects of silymarin on NF- k B activation were speciﬁc, as AP-1 activation was unaffected. Silymarin also inhibited the TNF-induced activation of mitogen-activated protein kinase kinase and c-Jun N-terminal kinase and abrogated TNF-induced cytotoxicity and caspase activation. Silymarin suppressed the TNF-induced production of reactive oxygen intermediates and lipid peroxidation. Overall, the inhibition of activation of NF- k B and the kinases may provide in part the molecular basis for the anticarcinogenic and anti-inﬂammatory effects of silymarin,
E-Business Adoption among Homestay Businesses: The Sarawak Experience

Information technology (IT) is now universally deemed by business organizations as an essential tool that they use to run their business activities and processes. The escalation of internet penetration in Sarawak has augmented new opportunities to the small medium enterprises (SMEs) to adopt e-business toward sustaining their businesses. The objectives of this study are to identify factors that influence e-business adoption among homestays in Kuching, Sarawak and to determine which factor has the most significant influence in its adoption. For the purpose of this study, the reviewed IT adoption model used is the technology-organization-environment (TOE) framework. This framework identifies three elements that drive the adoption of technology which are technological, organizational and environmental factors. A total of 150 homestay businesses within the city of Kuching were chosen to participate in the survey. Data were analysed using correlation analysis and multiple regression analysis. The findings indicated that organizational factor has the most significant influence on e-business adoption among the homestay owners in Kuching, Sarawak.
Mental Health Problems in Iraq: a Systematic Review

------------Abstract Objective: Most of the population worldwide is suffering from mental health problems. For the last four decades, Iraq has had a long history of wars and terrorist activities that have seriously hampered development and, therefore, there is limited research that has been carried out that focuses on the mental health of the nation, not to mention all the related psychological or other medical issues that result from poor mental health. Therefore, this systematic review aims to evaluate the prevalence and trend of mental illness in Iraq. Materials and methods: By using the protocol of PRISMA, 33 English-language articles were searched in the major databases, (PubMed, EMBASE and MEDLINE). With the help of specific keywords such as “mental health in Iraq”, “anxiety”, “depression”, “Iraq survey”, “psychosis”, “postpartum”, “prevalence of mental illness in Iraq”, “prevalence of mental disorders in Iraq”. 14 articles were finally selected for further data extraction. Results: Findings revealed that many different factors are responsible for the mental health problems, such as violence, war, people with diabetes, stressful environments, infertile women, parents of children with cancer, and old age. Topics such as child and adolescent mental health include hospital-based studies on the psychiatric problems of children, community-based investi-gations on the mental health of minority groups, the prevalence rate among different age groups within the child and adolescent population, and studies on prevention and intervention strategies for boosting mental healthcare should all be considered for further investigation. Conclusion: This systematic review indicated that research into the mental health field needs to be regarded as a priority focus for the country. Though major factors have been identified, there is an uneven distribution of the present mental health situation and published studies.
CASE STUDIES IN GENDER INTEGRATION Market-based solutions in Cambodia GENDER CONSIDER ATIONS for Maternal Nutrition Interventions and Supplementation in Pakistan

A variety of interventions, including those involving supplementation, target undernourished pregnant and breastfeeding women. A successful intervention strategy must be informed by data and evidence on potential gender barriers to effective demand, and learning from culturally specific gender norms and practices to optimize uptake while avoiding unintended harmful consequences with respect to gender inequality. This brief is intended to inform the design of nutrition interventions, especially those involving supplements, for pregnant and breastfeeding women in Pakistan by: (1) analyzing regional and sociodemographic variations in intrahousehold decision-making, antenatal care, and food expenditures; (2) identifying key gender norms and practices with relevance for nutrition; and (3) synthesizing evidence from previous interventions engaging men and addressing norms to improve MNCH in Pakistan and other South Asian countries.