Miracle-dz/UniFAR-FTUs huggingface dataset:
Diaries

Dr. Kenneth Keele has for many years been engaged in examining the anatomical drawings and notes of Leonardo from . the point of view of the cardiologist and the book embodying the results of his long study is happily timed to appear as a quincentenary tribute. * The anniversary will be celebrated in this country by a special exhibition at the Royal Academy which is now being prepared by a committee of distinguished artists and . scientists. Of these, Dr. Sherwood Taylor, Director of the Science Museum, has undertaken responsibility for the scientific, and Dr. Keele for the anatomical exhibits. Our readers are urged not to miss the rare opportunity which this exhibition will provide of judging Leonardo's work as a whole, and in particular of seeing the originals of the anatomical drawings from the Royal Library at Windsor which are being lent by His Majesty the King for this occasion. * Leonardo da Vinci on Afot'ement of the Heart and Blood, by K. D. Keele, M.D., F.R. C.P. London: Harvey & Blythe.
The Theatre of Grotowski

First published in 1985, this is a reissue of the seminal text on the work of Jerzy Grotowski and Laboratory Theatre recognised as being one of the most influential and important studies of the Polish theatre practitioner. In 1984 Grotowski's Laboratory Theatre closed down after twenty-five years of ceaseless experimentation pushing at the boundaries of the nature of theatre. From tiny beginnings in provincial Poland, Grotowski's influence spread to Eurpoe and the United States, fuelled first by the international tours of his remarkable company and then by 'paratheatrical' participatory projects which attracted adherents all over the world. This magnificent study of his work remains one of the most important and thorough examinations of the history, theory and post-theatre work of this most influential of theatre practitioners.
Early Impulse Control: Treatment of Potential Errors within Pre-Programming and Control

Abstract Early aiming adjustments following an online perturbation are made possible by impulse control. This process may unfold even earlier when perturbations impose a greater risk of a costly overshoot error. Participants executed upward and downward aims to mediate the cost of potential errors—downward overshoots require more energy to correct against gravity. On 33% of the trials, texture elements on the aiming surface were shifted following onset to appear congruent or incongruent with the aiming direction, and consequently generate a misperception of the limb moving slower or faster, respectively. Thus, the risk of potential errors could be influenced by the online perturbation (e.g., increased perceived likelihood of overshooting following the incongruent background). Findings indicated greater undershooting for down compared to up, which reflects the principle of movement optimisation. There was also more undershooting for an incongruent compared to congruent background, which is consistent with early online adjustments counter-acting the misperceived limb velocity. However, there were no interactions throughout the movement trajectory. We suggest that while the initial pre-programme considers the cost of potential errors (target direction), early impulse control fails to discriminate the likelihood of these errors occurring following an online perturbation (moving background).
Transportation Systems Analysis: Models and Applications

Modeling Transportation Systems: Preliminary Concepts and Application Areas. - Transportation Supply Models. - Random Utility Theory. - Travel-Demand Models. - Basic Static Assignment to Transportation Networks. - Advanced Models for Traffic Assignment to Transportation Networks. - Intraperiod (Within-Day) Dynamic Models. - Estimation of Travel Demand Flows. - Transportation Supply Design Models. - Methods for the Evaluation and Comparison of Transportation System Projects.
Growing Old on the Suburban Fringe: Master Planned Communities and Planned Diversity

This paper investigates the situation of older people who have moved to the post-traditional successor to the Australian suburb, the outer suburban ‘master planned community’ (MPC). The purpose of the paper is to discuss the needs and expectations of older residents for supportive community of place, in contrast to the needs and motivations of the property developer in ‘creating community’. The new MPC of Springfield Lakes on the outskirts of Brisbane will provide the backdrop for the paper; and qualitative data from interviews with older residents of Springfield Lakes and the staff of the development company, Delfin Lend Lease, will be used to illustrate the possible tensions and contradictions that arise from a strategy of planning for diversity. Springfield Lakes is emerging as a community that accommodates multigenerations, but there are questions about whether this strategy of diversity is in the interests of those older residents who might not exercise the agency to construct their own model of community in their Third Age. The author is a member of an ARC Linkage project: ‘Building Sustainable Social Capital in New Communities’, in conjunction with the property developer Delfin Lend Lease
Youth anti-racism action: Contributions of youth perceptions of school racial messages and critical consciousness.

The current study examined whether youth perceptions of school racial messages that acknowledged the reality of racism (critical consciousness [CC] messages) or denied racism (color-blind messages) predicted youth anti-racism action through interpersonal and communal/political means. We further tested whether youths' critical reflection of perceived inequality and anger toward social injustice-psychological aspects of CC development-mediated relations between school messages and youth actions. These questions were explored using structural equation modeling with 372 racially/ethnically diverse adolescents (Mage = 17.00; standard deviation = 1.29; female = 51.0%). Results indicated that youth perceptions of CC messages predicted their involvement in both interpersonal and communal/political anti-racism action. Youths' anger toward social injustice mediated links between school racial messages and anti-racism action, albeit in unique ways. These findings underscore the power of schools in prompting youth anti-racism action. Implications of the importance of partnerships between schools and youth community organizing groups to stimulate youth anti-racism action were discussed.
SKEW EFFECTS ON BACKFILL PRESSURES AT FRAME BRIDGE ABUTMENTS

The abutments of frame bridges are integrally connected to the deck without expansion joints. Active soil pressures are normally considered in design despite the movement of the abutments into the soil from thermal expansion of the deck. Many abutments are located on a skew, but possible effects of this skew on the backfill soil pressures are not considered in design. To improve the knowledge of soil pressures behind a skewed integral abutment for use in designing this type of bridge, soil pressures were measured on an installed project for 33 months. The soil pressure measurements were taken using total pressure cells in the backfill on each side of the centerline for both abutments of a 20-degree skewed bridge in Maine. A total of 16 pressure cells plus temperature indicators have been monitored four times a day using a data acquisition system since October 1989. Expansion of the deck causes the pressure to increase well above the active conditions on the upper part of the abutment wall. Skew effects on the pressures that develop near the deck level behind the abutment wall of an integral abutment are substantial. When the greatest deck expansion occurs, the pressures at 3 m (10 ft) from centerline on the obtuse side reach almost three times the value at the corresponding distance on the acute side. The horizontal variation of pressure is greater than the vertical variation. A design envelope is proposed.
AGE AND SEX DIFFERENCES IN DRIVING PERFORMANCE: SOME PRELIMINARY FINDINGS FROM THE ASTON DRIVING SIMULATOR

the aston research programme on driver behaviour involves several methods of data collection, most of them indirect. these include judgments, scale-ratings and questionnaires. to supplement these with more direct data on behaviour, a low-cost driving simulator was required. the simulator selected was based on an acorn archimedes personal computer with 2 megabytes of memory. the aims of this pilot study were first to assess the hardware and software for design problems; second to determine whether the simulator discriminated between groups of drivers, and finally to replicate and extend hagen's (1975) experiment on sex and age differences in driving performance. this preliminary study support hagen's (1975) findings with respect to significant sex differences in mean speed and maximum speed, mean accelerator input and maximum accelerator input. males drove significantly faster and used the accelerator significantly more. however, while hagen found that males were less consistent in their operation of the accelerator, no significant difference emerged in the current study with respect to mean accelerator pedal use, although females exhibited greater variability in the maximum accelerator pedal measure. however, given that this study found significant differences between young and old males on this measure, it is likely that age was a confounding factor in the hagen study. while the means for hagen's groups of subjects were similar to those of the young groups in this study, the age range was greater. with respect to position on road, compared with young females, males in this study drove closer to the centre as in hagen (1975). males also used the brake pedal significantly more. for the covering abstract of this seminar see irrd 845356.
The Human Resource Management and the Profitability, in Turkish Banking Sector: Evidence Within the “Leap Period”

Since the concurrence reached its highest level at the last decades of the 20th century, the firms are in the search of gaining the competitive advantage. After have seen the impact of the strategic resources, scholar have focused to find the new ones. Human resource management had a considerable potential to contribute to the firm performance. In spite of evidence the relationship between the HRM and the firm performance, there are still some uncertainties: First, is it really acceptable to trust the perceptions of the respondents, particularly since they evaluate both HRM and the performance. And secondly, is it really certain that HRM ensures the profitability (but not the profitability ensures the HRM). In order to answer these questions, the annual activity reports (between 2010-2019) of the commercial banks in Turkey are analyzed. The data gathered from the HRM sections and the financial sheets are compared. Based on the intensity of new HRM practices starting and their impact on ROA, it is argued that HRM is one the factors that ensure the profitability, when it is driven in a leap period.
Relationship Between Audit Manager Experience and Compliance Audit Outcomes

This study examines variables that effect on Illinois Auditor General compliance audit outcomes. Specifically, the compliance reports the Auditor General staff complete. The variables added focus on the experience level of each audit manager and how that experience affects audit outcomes including; material findings, immaterial findings, and total findings. The results of this study show there is a significant relationship between an audit managers prior experience and the resulting findings. Additionally, this study confirms and adds further data to work done by Branson, Nation, & Stephens (2016) in which audit hours have a significant positive relationship with audit findings.
The Dynamic Dial-a-Ride Problem with Time Windows in a Competitive Multi-Company Environment

Door-to-door transportation for elderly and disabled people is for many governments an important instrument to increase the mobility of this group of people. Many issues arise in the implementation of such a system, which is often modeled as the Dynamic Dial-a-Ride System with Time Windows (DDARPTW). One of those issues is that taxi companies try to maximize their profit by combining as many rides as possible. This leads to longer travel times, a measure that is expressed in the service quality of a ride. Our main contribution is a system in which multiple companies compete on service quality to increase the average service quality of the rides. We use an auction mechanism to assign rides to companies and an on-line optimization technique to insert assigned rides into current schedules. To determine an offer for announced requests, we allow companies to use knowledge about the distribution of future requests by the use of a Monte Carlo simulation.
Epigenetic modification of H3K4 and oxidative stress are involved in MC‐LR‐induced apoptosis in testicular cells of SD rats

Microcystin‐leucine arginine (MC‐LR) is a cyclic heptapeptide, produced by aquatic cyanobacteria such as microcystis, with strong reproductive toxicity which poses greater threat to the reproductive abilities of humans and animals. By exploring the role of trimethylation of histone H3 at lysine 4 (H3K4me3) and the role of oxidative stress in MC‐LR‐induced apoptosis in testicular Sertoli cells in Sprague‐Dawley (SD) rats, this study indicated that MC‐LR increased the expression levels of apoptosis‐related genes by raising the levels of H3K4me3. 5′‐Deoxy‐5′‐methylthioadenosine (MTA), the inhibitor of H3K4me3, reduced apoptosis, indicating for the first time that epigenetic modification is closely related to the testicular reproductive toxicity induced by MC‐LR. MC‐LR also induced oxidative stress by stimulating the generation of reactive oxygen species (ROS), and subsequently triggering mitochondria‐mediated apoptotic pathway by decreasing mitochondrial membrane potential and increasing the levels of Bax, Bcl‐2, Caspase‐3, and so on. MC‐LR‐induced apoptosis of testicular cells could be decreased after pretreatment with oxidative stress inhibitor N‐acetyl‐cysteine (NAC). Furthermore, the pathological damage to mitochondria and testes were observed in SD rats. These results show that MC‐LR can induce apoptosis by raising the levels of H3K4me3, and pretreatment with MTA can ameliorate the MC‐LR‐induced apoptosis of cocultured cells by lowering the levels of H3K4me3. Furthermore, NAC has a protective effect on MC‐LR‐induced apoptosis of testicular cells in SD rats by inhibiting the oxidative stress.
Genes and Variants Underlying Human Congenital Lactic Acidosis—From Genetics to Personalized Treatment

Congenital lactic acidosis (CLA) is a rare condition in most instances due to a range of inborn errors of metabolism that result in defective mitochondrial function. Even though the implementation of next generation sequencing has been rapid, the diagnosis rate for this highly heterogeneous allelic condition remains low. The present work reports our group’s experience of using a clinical/biochemical analysis system in conjunction with genetic findings that facilitates the taking of timely clinical decisions with minimum need for invasive procedures. The system’s workflow combines different metabolomics datasets and phenotypic information with the results of clinical exome sequencing and/or RNA analysis. The system’s use detected genetic variants in 64% of a cohort of 39 CLA-patients; these variants, 14 of which were novel, were found in 19 different nuclear and two mitochondrial genes. For patients with variants of unknown significance, the genetic analysis was combined with functional genetic and/or bioenergetics analyses in an attempt to detect pathogenicity. Our results warranted subsequent testing of antisense therapy to rescue the abnormal splicing in cultures of fibroblasts from a patient with a defective GFM1 gene. The discussed system facilitates the diagnosis of CLA by avoiding the need to use invasive techniques and increase our knowledge of the causes of this condition.
Experimental and observational studies on alcohol use and dietary intake: a systematic review

The scientific literature on links among alcohol use, total energy intake, cardiometabolic disease and obesity is conflicting. To clarify the link between alcohol use and cardiometabolic health, this systematic review (PROSPERO CRD42016039308A) uses PRISMA (Preferred Reporting Items for Systematic Reviews and Meta‐Analyses) guidelines to synthesize how alcohol use affects dietary intake (carbohydrate, fat and protein intake) in humans. A search of Google Scholar, PsycINFO and PubMed from June 2016‐March 2019 yielded 30 qualified studies. Experimental and observational studies allowed for inferences about effects of a single drinking occasion and of frequent drinking, respectively. Alcohol quantities were standardized according to the 2015‐2020 Dietary Guidelines for Americans. On average, methodological quality of the studies was medium strength. Results indicated that a single occasion of light and moderate drinking as well as frequent light and moderate drinking were linked to greater fat and protein intake, albeit the majority of studies did not detect differences in dietary intake due to these drinking behaviours. Frequent heavy drinking, on the other hand, was linked to less carbohydrate intake in the majority of studies. Overall, alcohol use does not appear to uniformly affect diet but instead appears to affect intake of specific macronutrients in a dose‐dependent manner, most consistently decreasing carbohydrate intake with heavier use.
Electrical characterization and comparison of a novel covered PVT collector

Hybrid photovoltaic-thermal (PVT) collectors have been widely investigated in recent decades, since they include in a single device the two most diffused solar technologies: photovoltaic and solar thermal, ensuring higher overall performances and compactness with respect to separated components. In this study a novel PVT collector, able to reduce the optical losses as well as to increase the heat transfer toward the working fluid, is presented. In detail, the PV cells are directly laminated on the aluminium roll bond absorber without the front cover glass, which is added at the end of the lamination process above a spacer, creating an air gap. Obtained results showed that the novel collector maintains similar electrical characteristics to an uncovered PVT and even better performances than a traditional covered collector. Moreover, due to the air gap between cells and glass, the overall thermal losses from the surface are heavily reduced, with benefits in terms of thermal efficiency. The work proves that the direct lamination of PV cells above a roll-bond absorber within an air gap with a single glass layer as a cover could lead to a new generation of hybrid PVT collectors.
Assessing toxicity of FeMn dust particles collected from a South African ferromanganese smelter works : in vitro studies on primary rat astrocytes and BEAS-2B cells

iv List of Figures . vi List of Tables . ix Abbreviations . x Aim of Study . 1 Chapter 1: Introduction . 2 1.1. Airborne Particulate Matter . 2 1.2. Manganese . 3 1.3. Manganese Overexposure . 5 1.4. Studies Conducted on Manganese Overexposure in an Occupational Environment . 5 1.5. Biomarkers of Manganese Overexposure . 7 1.6. Accumulation and Transport of Manganese in the Body. 8 1.7. Central Nervous System . 10 1.8. Functions of Astrocytes in the CNS . 11 1.9. Lung exposure to Manganese . 13 1.10. Manganese Toxicity . 15 1.10. 1. Manganese Toxicity in Astrocytes . 15 1.10. 2. Manganese Toxicity in the Lung . 17 1.11. Particulate Matter induced Oxidative stress . 19 1.11.1. Transcription Factors Nrf2 and NF-κB . 19 1.11.2. Nrf2: Antioxidant Mediator . 22 1.11.3. NF-κB: Proinflammatory Mediator . 23 Chapter 2: Materials and Methods . 27 2.1. FeMn Dust Sampling . 27 2.1.1. Sample Preparation . 28 2.2. Dust Particle Characterization . 28 2.2.1. Scanning Mobility Particle Sizer (SMPS) and Aerodynamic Particle Sizer (APS) . 28 2.2.2. Brunauer-Emmett-Teller (BET) Analysis . 29 2.2.3. Inductively Coupled Plasma Atomic Emission Spectroscopy (ICP-AES) . 29 2.2.4. pH Measurements . 30 2.3. Cell Culturing . 31 2.3. 1. Primary Rat Astrocytes . 31 2.3. 1.1. Isolation . 31 2.3. 1.2. Dissociation . 32 2.3. 1.3. Culturing . 32 2.3. 2. Human Bronchial Epithelial Cells (BEAS-2B). 32 2.3. 2.1. Culturing . 32 2.3. 2.2. Cell Stocks . 33 2.3. 3. Trypan Blue Dye Exclusion Assay . 33 2.4. Cellular Uptake Studies . 34 2.4.1. CytoViva Hyperspectral Imaging System . 34 2.5. Cell Viability and Cytotoxicity Assays . 35 2.5.1. XTT Assay . 35 2.5.2. ATP Assay . 36 2.5. 3. LDH Assay . 36 2.5. 4. Particle Interference Studies (in the absence of cells) . 37 2.5. 4.1. XTT Assay . 37 2.5. 4.2. ATP Assay . 38 2.5. 4.3. LDH Assay . 38 2.5. 5. Real Time Cell Viability and Cytotoxicity Studies . 39 2.5. 5.1. Proliferation Curves . 39 2.5. 5.2. Cytotoxicity Experiments . 40 2.5. 6. Nuclear Translocation of Nrf2 and Nf-κB . 40 2.5. 6.1. Cell Fractionation . 41 2.5. 6.2. Bicinchoninic Acid (BCA) Protein Determination Assay . 41 2.5. 6.3. Sodium Dodecyl Sulphate Polyacrylamide Gel Electrophoresis (SDS-PAGE) . 42 2.5. 6.4. Preparation of the Nitrocellulose Membrane and Transfer of Proteins . 43 2.5. 6.5. Blocking and Antibody Treatment. 43 2.5. 6.5.1. Nrf2 . 44 2.5. 6.5.2. NF-ĸB p65 . 44 2.5. 6.6. Detection . 44 2.5. 6.7. Loading Control . 45 2.6. Genotoxicity Study . 46 2.6.1. Alkaline Comet Assay . 46 2.6.1.1. Cell Treatment . 46 2.6.1.2. Embedding the Cells in Agarose Gel. 47 2.6.1.3. Cell Lysis . 47 2.6.1.4. DNA Unwinding and Electrophoresis . 47 2.6.1.5. Visualization and Scoring . 47 2.7. Statistical Analysis .
Differential effects of text message reminders on non-attendance and late cancellations in a paediatric outpatient clinic.

INTRODUCTION SMS text appointment reminders reduce non-attendance rates in outpatient paediatric settings. The potential effect on late cancellation rates, however, has not been assessed. The aim of the present study was to assess if SMS text messaging reminders affect non-attendance and late cancellation rates in a secondary paediatric outpatient centre. METHODS Non-attendances and late cancellations in children and adolescents aged 0-19 years of age were recorded prospectively during a year before and after the introduction of automatic SMS text messaging reminders. In a telephone interview, the families of late-cancelling patients were asked about the reasons for their cancellation. RESULTS During the year before the introduction of SMS reminders, the clinic had 4,556 scheduled appointments in 1,466 patients (878 boys (59.9%) and 588 girls (40.1%); the year after the introduction, the clinic had 4,464 scheduled appointments in 1,424 patients (828 boys (58.1%) and 579 girls (41.9%). Before the introduction, 163 (4.3%) non-attendances and 162 (3.5%) late cancellations were recorded; after the introduction, 67 (1.5%) (p < 0.001) non-attendances and 177 (4.0%) (p = 0.28) late cancellations were recorded. During the no-SMS and SMS period, a total of 85 (52.5%) and 115 (65%) (p = 0.26), late cancelling families, respectively, said that that they had forgotten the appointment and could not manage to visit. CONCLUSIONS SMS text reminders only improved the non-attendance rate; they did not influence the late cancellation rate. Most late cancellations were explained by forgetfulness. FUNDING none TRIAL REGISTRATION: not relevant.