Miracle-dz/UniFAR-FTUs huggingface dataset:
A visual and acoustic survey for harbour porpoises off North-West Africa: further evidence of a discrete population

The distribution of harbour porpoises Phocoena phocoena in southern Europe and along the Atlantic African coast is poorly understood, with tentative assessments suggesting a discrete West African population with a northern limit around the Straits of Gibraltar. This study describes visual and acoustic surveys for porpoises in Atlantic waters of North-West Africa in spring 2005 between latitudes of 20°N and 37°N. During this period, 276h of acoustic data were collected in all sea states (from 3 125km of trackline) and 60h (824km) of visual effort was conducted in Beaufort sea states of three or less. Harbour porpoises were seen three times on the survey trackline and on four additional occasions off the trackline. The four individuals seen in Agadir Bay (30°N) represent the northernmost living porpoises reported from the Atlantic African coasts and the first sightings of porpoises reported in Moroccan waters. In addition, 31 acoustic detections were made on the survey trackline, of which 23 were made between Dakhla (24°N) and Cap Barbas (22°N). Fishing activities off North-West Africa are intense, ranging from small-scale artisanal gillnetters to international freeze-trawlers. Further monitoring of the status of this little known and isolated population is required for effective conservation management.
Synaptotagmin-1 is the Ca2+ sensor for fast striatal dopamine release

Dopamine powerfully controls neural circuits through neuromodulation. In the vertebrate striatum, dopamine adjusts cellular functions to regulate behaviors across broad time scales, but how the dopamine secretory system is built to support fast and slow neuromodulation is not known. Here, we set out to identify Ca2+-triggering mechanisms for dopamine release. We find that synchronous dopamine secretion is abolished in acute brain slices of conditional knockout mice in which Synaptotagmin-1 is removed from dopamine neurons. This indicates that Synaptotagmin-1 is the Ca2+ sensor for fast dopamine release. Remarkably, dopamine release induced by strong depolarization and asynchronous release during stimulus trains are unaffected by Synaptotagmin-1 knockout. Microdialysis further reveals that these modes and action potential-independent release provide significant amounts of extracellular dopamine in vivo. We propose that the molecular machinery for dopamine secretion has evolved to support fast and slow signaling modes, with fast release requiring the Ca2+ sensor Synaptotagmin-1.
The Effect of Divided Attention with Bounce Drop Jump on Dynamic Postural Stability

Abstract This study determined the effect of divided attention on controlling postural stability during a drop vertical jump task. In total, 30 participants were tested for drop vertical jumps from a 30-cm high platform and landing on a single leg with or without divided attention tasks. Three-dimensional marker trajectories and ground reaction forces were collected simultaneously. Vertical ground reaction force, loading rate, and dynamic postural stability index were analyzed with or without divided attention tasks. The paired sample t test indicated a significantly low knee flexion angle, high vertical ground reaction force, and increased loading rate in the divided attention task. Moreover, participants showed an increased vertical stability index and dynamic postural stability index in the divided attention task than in the nondivided attention task. Thus, results demonstrated that the divided attention task could affect posture control, leading to poor dynamic posture stability and possibly increasing lower extremity injury risk. The influence of the divided attention task on movement quality likely indicates that an athlete can no longer focus his attention on the bounce drop jump maneuver. Therefore, the bounce drop jump combined with dynamic postural stability index could be used in posture stability screening.
Absorption of immunomodulating β(1,3)‐glucan in yolk sac larvae of Atlantic halibut, Hippoglossus hippoglossus (L.)

A soluble immunomodulating β(1,3)-glucan, laminaran, was given in drinking water to yolk-sac larvae of Atlantic halibut, Hippoglossus hippoglossus L. The larvae absorbed laminaran when the concentration was 25 mg l–1. After 5 days exposure to laminaran, each larva contained 2.3 ng and 46 ng of 3H- and 125I-labelled laminaran, respectively. After 10 days exposure, each larva contained 4.5 ng and 47 ng of 3H- and 125I-laminaran, respectively. The absorption was confirmed by fluorescence microscopy of larvae exposed to fluorescein-labelled laminaran (FITC-laminaran). The fluorescence was localized to cells in the intestinal epithelial layer and the skin epithelial layer.
Undisturbed climbing fiber pruning in the cerebellar cortex of CX3CR1‐deficient mice

Pruning, the elimination of excess synapses is a phenomenon of fundamental importance for correct wiring of the central nervous system. The establishment of the cerebellar climbing fiber (CF)‐to‐Purkinje cell (PC) synapse provides a suitable model to study pruning and pruning‐relevant processes during early postnatal development. Until now, the role of microglia in pruning remains under intense investigation. Here, we analyzed migration of microglia into the cerebellar cortex during early postnatal development and their possible contribution to the elimination of CF‐to‐PC synapses. Microglia enrich in the PC layer at pruning‐relevant time points giving rise to the possibility that microglia are actively involved in synaptic pruning. We investigated the contribution of microglial fractalkine (CX3CR1) signaling during postnatal development using genetic ablation of the CX3CR1 receptor and an in‐depth histological analysis of the cerebellar cortex. We found an aberrant migration of microglia into the granule and the molecular layer. By electrophysiological analysis, we show that defective fractalkine signaling and the associated migration deficits neither affect the pruning of excess CFs nor the development of functional parallel fiber and inhibitory synapses with PCs. These findings indicate that CX3CR1 signaling is not mandatory for correct cerebellar circuit formation.
Exploiting the RSSI Long-Term Data of a WSN for the RF Channel Modeling in EPS Environments

In this paper, we propose a methodology to use the received signal strength indicator (RSSI) available by the protocol stack of an installed Wireless Sensor Network (WSN) at an electric-power-system environment (EPS) as a tool for obtaining the characteristic of its communication channel. Thereby, it is possible to optimize the settings and configuration of the network after its deployment, which is usually run empirically without any previous knowledge of the channel. A study case of a hydroelectric power plant is presented, where measurements recorded over a two-month period were analyzed and treated to obtain the large-scale characteristics of the radiofrequency channel at 2.4 GHz. In addition, we showed that instantaneous RSSI data can also be used to detect specific issues in the network, such as repetitive patterns in the transmitted power level of the nodes, and information about its environment, such as the presence of external sources of electromagnetic interference. As a result, we demonstrate the practical use of the RSSI long-term data generated by the WSN for its own performance optimization and the detection of particular events in an EPS or any similar industrial environment.
Immunohistochemical Studies of Cytokeratins and Differentiation Markers in Bovine Ocular Squamous Cell Carcinoma

Bovine Ocular Squamous Cell Carcinoma is considered the most common bovine tumour, causing significant economic losses, mainly by abattoir condemnations. To obtain a better insight into the genesis and neoplastic transformation, 19 samples collected at slaughter from Holstein Friesian cattle and diagnosed as Ocular Squamous Cell Carcinoma were studied. Tumours were histologically classified into three categories: poorly (26.3%), moderately (26.3%), and well differentiated (47.4%). Expression of keratins (MNF116 and LP34) and of cornified envelope precursors (involucrin and profilaggrin) was studied. Expression of MNF116 was observed in all carcinomas. LP34 immunostaining was seen in all but three carcinomas, one from each degree. Involucrin immunoreaction was observed in all but one poorly differentiated carcinoma. Profilaggrin was present in only two moderately differentiated carcinomas, in all but one well differentiated, and in all but one poorly differentiated. MNF116 is a useful marker to confirm the epithelial origin of the tumour and stain most neoplastic cells in these tumours. The expression of involucrin and LP34 demonstrates that, in all tumours, cells have reached the final program of differentiation, regardless of the grade. The expression of profilaggrin could indicate molecular changes during malignant transformation but their expression does not seem to be of diagnostic value.
Recurrent GANs Password Cracker For IoT Password Security Enhancement †

Text-based passwords are a fundamental and popular means of authentication. Password authentication can be simply implemented because it does not require any equipment, unlike biometric authentication, and it relies only on the users’ memory. This reliance on memory is a weakness of passwords, and people therefore usually use easy-to-remember passwords, such as “iloveyou1234”. However, these sample passwords are not difficult to crack. The default passwords of IoT also are text-based passwords and are easy to crack. This weakness enables free password cracking tools such as Hashcat and JtR to execute millions of cracking attempts per second. Finally, this weakness creates a security hole in networks by giving hackers access to an IoT device easily. Research has been conducted to better exploit weak passwords to improve password-cracking performance. The Markov model and probabilistic context-free-grammar (PCFG) are representative research results, and PassGAN, which uses generative adversarial networks (GANs), was recently introduced. These advanced password cracking techniques contribute to the development of better password strength checkers. We studied some methods of improving the performance of PassGAN, and developed two approaches for better password cracking: the first was changing the convolutional neural network (CNN)-based improved Wasserstein GAN (IWGAN) cost function to an RNN-based cost function; the second was employing the dual-discriminator GAN structure. In the password cracking performance experiments, our models showed 10–15% better performance than PassGAN. Through additional performance experiments with PCFG, we identified the cracking performance advantages of PassGAN and our models over PCFG. Finally, we prove that our models enhanced password strength estimation through a comparison with zxcvbn.
Exploring Predictors of Affective State during d-Amphetamine Intake

Possible predictors of positive and negative affective response to oral d-Amphetamine were examined in healthy adults using secondary data analysis on two datasets. The predictors examined included subjective response to the drug, midbrain D2/D3 binding potential, and stable personality traits. Using correlational analyses, D2/D3 binding potential and stable personality traits were found to not have significant associations with positive or negative affect. In contrast, subjective response to d-amphetamine was found to be positively associated with negative affect, though this finding did not replicate across datasets. In subsequent multiple regression models, one dataset showed a significant positive relationship between negative affect and the degree to which participants subjectively felt the effects of the drug, while the other dataset showed a significant positive relationship between negative affect and the degree to which participants subjectively disliked the effects of the drug. Though the lack of replication across datasets makes it difficult to draw definitive conclusions, these findings suggest that negative affect may play a major role in people’s experience of drug use. PSY-4999: Honors Thesis, Amy Booth
Potencial produtivo de progênies de feijão-caupi com arquitetura ereta de planta

This research was carried out to estimate genetic parameters and to identify, in cowpea populations, promising genotypes regarding grain yield and erect plant type. Three lines and 348 progenies, coming from advanced generations of crossings between: TE96-282-22G (P1) x TVx5058-09C (P2) and TE96-282-22G (P1) x 1T81D-1332 (P3), were evaluated in the Teresina, PI, in 2004. The genetic variability for the main branch node number, and for the number of pods per plant indicates favorable condition for selection of superior progenies, considering these characters. The populations that stood out for grain yield, are among those presenting higher length and number node in the main branche. The absence of correlation for the main branch length with number of pods per plant and with weight of a hundred grains indicates the possibility of selecting genotypes with erect plant type, higher seed size and pod production.
Supplementary feeding pattern and rate of liveweight gain in winter-spring affect wool production of young Merino sheep on the south coast of Western Australia

The effects of different supplementary feeding practices in summer-autumn and management strategies on green pasture on liveweight change, wool growth rate, annual wool production and wool characteristics of young Merino wethers were examined at 2 farms. The grain feeding treatments were lupins (L) or lupins and oats (LO) fed in amounts that were adjusted to try and maintain liveweight, or lupins and oats (LOG) fed at a higher rate. The objectives of liveweight maintenance or gain were not always achieved, but liveweight patterns differed between LOG compared with L or LO during summer-autumn. The sheep used at farm 1 were aged 4.5 months and liveweight 32 kg at the start of the experiment, while those at farm 2 were 6.5 months and liveweight 39 kg. The stocking rate in summer-autumn was 8 wethers/ha at both farms. During supplementation, sheep on LOG had a higher (P<0.05) liveweight change compared with those on L or LO (farm 1, 15 v. -8 g/sheep. day; farm 2, -35 v. -51 g/sheep. day) and clean wool growth rates (farm 1, 7.1 v. 6.4 g/sheep. day; farm 2, 5.1 v. 4.8 g/sheep.day). The sheep on LOG grew broader (P<0.05) wool than those on L or LO (farm 1, 19.0 v. 18.5 ¦m; farm 2, 21.7 v. 20.8 ¦m), and at farm 1 length was also greater (P<0.05) (114 v. 111 mm), while at farm 2 staple strength was greater (P<0.01) (22.9 v. 16.4 N/ktex). There were no significant differences in annual clean wool production. There were positive (P<0.01) relationships between staple strength and liveweight change to the time of minimum liveweight in summer-autumn. After green pasture on offer reached 500 kg DM/ha in autumn, different liveweight change patterns were achieved in 2 groups (LS, lower stocking rates; HS, higher stocking rates) of sheep at each farm by adjusting stocking rates. Within a farm, the LS and HS groups were comprised of equal numbers of sheep from each replicate of the supplementary feeding treatments. There were differences (P<0.05 to 0.01) in liveweight change between LS and HS (farm 1, 93 v. 72 g/day; farm 2, 127 v. 60 g/day), the differences being more pronounced at farm 2. The differential stocking rates at farm 2 resulted in differences in clean wool growth rates (P<0.01), in clean wool production (4.22 v. 4.53 kg, P<0.05), and fibre diameter (20.8 v. 21.4 ¦m, P<0.01), but there were no significant effects on staple length or strength. There were no significant effects of the supplementary feeding treatments imposed in summer-autumn on the responses to the stocking rate treatments on green pasture.
Anabolic Properties of Mixed Wheat-Legume Pasta Products in Old Rats: Impact on Whole-Body Protein Retention and Skeletal Muscle Protein Synthesis

The mechanisms that are responsible for sarcopenia are numerous, but the altered muscle protein anabolic response to food intake that appears with advancing age plays an important role. Dietary protein quality needs to be optimized to counter this phenomenon. Blending different plant proteins is expected to compensate for the lower anabolic capacity of plant-based when compared to animal-based protein sources. The objective of this work was to evaluate the nutritional value of pasta products that were made from a mix of wheat semolina and faba bean, lentil, or split pea flour, and to assess their effect on protein metabolism as compared to dietary milk proteins in old rats. Forty-three old rats have consumed for six weeks isoproteic and isocaloric diets containing wheat pasta enriched with 62% to 79% legume protein (depending on the type) or milk proteins, i.e., casein or soluble milk proteins (SMP). The protein digestibility of casein and SMP was 5% to 14% higher than legume-enriched pasta. The net protein utilization and skeletal muscle protein synthesis rate were equivalent either in rats fed legume-enriched pasta diets or those fed casein diet, but lower than in rats fed SMP diet. After legume-enriched pasta intake, muscle mass, and protein accretion were in the same range as in the casein and SMP groups. Mixed wheat-legume pasta could be a nutritional strategy for enhancing the protein content and improving the protein quality, i.e., amino acid profile, of this staple food that is more adequate for maintaining muscle mass, especially for older individuals.
Predictors of Engagement in a Pediatric Weight Management Clinic after Referral.

Background: Little is known about factors that affect a family's ability to engage in pediatric weight management clinics (PWMCs). We aimed at comparing child and family characteristics of patients referred to a PWMC by participants' attendance at orientation, attendance at intake, or completing the program. Methods: We performed a retrospective study of patients ages 2-18 years referred to a PWMC between 2014 and 2017. We extracted data from electronic medical records and clinic databases, including age, sex, race/ethnicity, language, referral year, address, and insurance. We performed t-tests and chi-square tests to examine the association of engagement outcomes with covariates. We used separate multivariate logistic regression models to assess the predictors of engagement outcomes, including significant covariates from bivariate analyses. Results: Participants (N = 2020 referred) had a mean age of 11.5 ± 3.5 years; 72% had Medicaid, and 34% lived in city limits. Participants were 39% white, 30% black, and 27% Hispanic. Of those referred, 41% attended orientation, 14% attended intake, and 9% completed. Significant predictors of attending orientation were age [odds ratio (OR): 0.93, 95% confidence interval (CI): 0.91-0.96], male sex (OR: 0.74, 95% CI: 0.60-0.91), Hispanic ethnicity (OR: 1.69, 95% CI: 1.26-2.26), living in city limits (OR: 1.39, 95% CI: 1.11-1.75), and Medicaid (OR: 0.77, 95% CI: 0.60-0.98). Significant predictors of attending intake were age (OR: 0.93, 95% CI: 0.90-0.96), Medicaid (OR: 0.61, 95% CI: 0.46-0.81), and 2017 referral year (OR: 0.21, 95% CI: 0.12-0.35). Hispanic ethnicity was associated with twice the odds of completion (OR: 2.07, 95% CI: 1.10-3.91). Conclusions: Child and family characteristics more strongly predicted initial engagement with a PWMC than completion. Future research should examine how targeting these predictors (e.g., referring at younger age) can improve PWMC engagement.
Combined Optimization of Codon Usage and Glycine Supplementation Enhances the Extracellular Production of a β-Cyclodextrin Glycosyltransferase from Bacillus sp. NR5 UPM in Escherichia coli

Two optimization strategies, codon usage modification and glycine supplementation, were adopted to improve the extracellular production of Bacillus sp. NR5 UPM β-cyclodextrin glycosyltransferase (CGT-BS) in recombinant Escherichia coli. Several rare codons were eliminated and replaced with the ones favored by E. coli cells, resulting in an increased codon adaptation index (CAI) from 0.67 to 0.78. The cultivation of the codon modified recombinant E. coli following optimization of glycine supplementation enhanced the secretion of β-CGTase activity up to 2.2-fold at 12 h of cultivation as compared to the control. β-CGTase secreted into the culture medium by the transformant reached 65.524 U/mL at post-induction temperature of 37 °C with addition of 1.2 mM glycine and induced at 2 h of cultivation. A 20.1-fold purity of the recombinant β-CGTase was obtained when purified through a combination of diafiltration and nickel-nitrilotriacetic acid (Ni-NTA) affinity chromatography. This combined strategy doubled the extracellular β-CGTase production when compared to the single approach, hence offering the potential of enhancing the expression of extracellular enzymes, particularly β-CGTase by the recombinant E. coli.
Feasibility of the Oberlin Procedure in Late Presentation Cases of C5-C6 and C5-C7 Brachial Plexus Injuries in Adults

Background: Oberlin et al presented a new technique for nerve transfer that completely changed the prognosis of patients with brachial plexus injury. Currently, most of the literature addresses cases submitted to early surgical intervention, before 12 months from injury, showing consistent good results. The aim of this study was to evaluate the feasibility of the Oberlin procedure in late presentation cases (≥12 months), comparing the elbow flexion strength with patients operated earlier. Methods: We retrospectively reviewed 49 patients with partial brachial plexus injuries submitted to the Oberlin procedure. They were divided into 2 groups. Group A included 39 patients operated with <12 months of injury. The mean postoperative follow-up was 22.53 months. The interval from injury to surgery varied from 4 to 11 months (±8.45 months). Group B included 10 patients with surgery ≥12 months after injury. The mean postoperative follow-up was 32 months. The interval from injury to surgery ranged from 12 to 19 months (±15.4 months). Patients were evaluated monthly after surgery and the elbow flexion strength was measured using the British Medical Research Council scale. Results: In Group A, 24 patients presented with either good (M3) or excellent (M4) elbow flexion strength. In Group B, 9 patients presented with either good (M3) or excellent (M4) elbow flexion strength. A significant difference was not seen in the postoperative elbow flexion strength among the 2 groups. Conclusion: Biceps reinnervation with the Oberlin procedure is still feasible and should be attempted after more than 12 months of injury in partial brachial plexus injuries.
Factors Influencing Family Environment Reporting Concordance Among U.S. War Zone Veterans and Their Partners

A key challenge in the assessment of family variables is the discrepancies that arise between reports. Although prior research has observed levels of interpartner agreement on the family environment, no studies have investigated factors that may influence agreement. In this study, war zone veterans (WZVs) and their partners (N = 207 couples) completed assessments of the family environment. We examined interpartner agreement in relation to WZV and partner posttraumatic stress disorder (PTSD) symptoms, WZV time away from home, and family size. More severe WZV PTSD symptoms were associated with greater interpartner agreement on family environment, whereas more severe partner PTSD symptoms were associated with reporting more negative perceptions of the family environment relative to WZV reports. Family size was associated with greater interpartner agreement. Factors associated with concordance in this study should be considered by clinicians and researchers seeking to understand and address reporting discrepancies on the family.