Miracle-dz/UniFAR-FTUs huggingface dataset:
Characterization of the MSP-1 Protein in Field Samples of Plasmodium falciparum and its Homology to the Plasmodium vivax MSP-1 Protein

Merozoite surface protein-1 (MSP-1) is one of the several proteins on the surface of the asexual merozoite of malaria parasites. It undergoes a two stage proteolytic cleavage to form a C-terminal 19-kDa fragment or PfMSP119 that is used for red blood cell invasion. A homologue of PfMSP-119 of Plasmodium falciparum called PvMSP-119 has been identified in Plasmodium vivax. Recently, attention has been focused on this C-terminal cysteine-rich region as an important determinant of haplotypes that characterize the malaria parasite in endemic areas. In this study, sequence specific primers were used to determine the PfMSP-119 haplotypes from field samples and PvMSP-119 haplotypes from both field and Aotus adapted parasites. 163 PfMSP-119 samples from Kisumu-Kenya were polymerase chain reaction (PCR) typed at position 1644 in the first epidermal growth factor (EGF)-like domain followed by sequencing of a random selection of positive samples so as to evaluate molecular changes at positions 1691, 1700 and 1701 in the second EGF-like domain. 121 selected samples gave bands, with 80% typing as GAA (E) and 20% as CAA (Q) at position 1644. From computer-alignment sequences, samples 96B216 confirmed as the Uganda-PA haplotype (E-KNG), 96B209 as the PfMAD20 haplotype (E-TSR), 96B208 as the PfK1/Wellcome haplotype (Q-KNG), 96B183 as the Uganda-PA haplotype (E-KNG) and 96B017 as the E-TSG haplotype. Next, genotyping and sequence analyses of the PvMSP-119 fragment against reference sequences from GenBank demonstrated isolates as belonging to either one or the other of two parental haplotypes identified as Belem and Sal-1 strains. Comparison of PfMSP-119 and PvMSP-119 fragments demonstrated highly conserved cysteine amino acids in the two EGF-like domains. Key words: Merozoite surface protein-1 (MSP-1), polymerase chain reaction (PCR), Plasmodium falciparum, epidermal growth factor (EGF), GenBank, Plasmodium vivax, malaria parasite.
SHARED KNOWLEDGE AMONG GRAPHIC DESIGNERS, INSTRUCTIONAL DESIGNERS AND SUBJECT MATTER EXPERTS IN DESIGNING MULTIMEDIA- BASED INSTRUCTIONAL MEDIA

The research identified and explored the shared knowledge among the instructional multimedia design and development experts comprising of subject matter expert, graphic designer and instructional designer. The knowledge shared by the team was categorized into three groups of multimedia design principles encompasses of basic principles, authoring principles and design principles. The research focused on soliciting knowledge of agreement on the principles. The research design sequentially began with the modified Delphi technique which involved twelve experts in selecting the list of principles in multimedia design. Next phase, the interview session involved three selected experts to verify the list of principles and obtain detailed information. Outcome of the research is essential in providing description of the cognitive skills needed to perform tasks in multimedia design and development proficiently.
Do community members are aware of obstetric fistula? A community based cross sectional study, Dabat district, Northwest Ethiopia.

Background: Obstetric fistula results from complex interactions of social, biological, and economic influences. Community-awareness can affect hopes and the attitude of fistula patients and could influence the decision of women to seek medical care. This study was aimed at determining community awareness towards obstetric fistula and its associated factors among Dabat district residents, Amhara National Regional State, Ethiopia. Methods: Community-based cross sectional study was conducted using a semi-structured pretested questionnaire. The survey was followed by focus group discussions. Data were coded, and entered to Epi data version 2.0. 11.61 and exported to SPSS version 20. Descriptive statistics were presented in triangulation with qualitative findings and Logistic regression models were fitted to identify factors associated to awareness. Odds Ratios with 95% CI, p ≤ 0.05 were considered to confirm significance. Results: Seven hundred ninety nine respondents participated in the study with 99.1% response rate. Participants mean age was 38.5±11.3 and 48.2% were females. Among them 36.7% attended formal education, 73.4% heard about obstetric fistula and 54.7% were deemed to have awareness. Reported perceived causes include prolonged labor 39.6%, injury during surgery 9.6% and ‘God’s curse’ 6.7%. The odds of having awareness was 1.87 times higher among females than males (AOR=1.87; 95% CI, 1.64-4.83). Individuals who attended formal education had 3.48 times (AOR= 3.48; 95% CI, 2.4-7.67) and those government employees have 1.6 times (AOR=1.60; 95% CI, 1.10-7.19) higher odds of awareness compared to those who did not attend formal education, and farmer participants respectively. The odds of awareness was 8.2 times higher among individuals who had prior information about obstetric fistula (AOR=8.215; 95% CI, 7.16-11.98) compared to those who did not have prior information. Conclusions: More than half of the participants had awareness towards obstetric fistula but there were few mis perceptions and misconceptions on its nature. Being female, attending formal education, being a government employee, having prior information were factors associated to awareness. Hence, further community awareness creation actions are required in offering accurate information on the causes, nature, and management of obstetric fistula. Key Words: Awareness, Obstetric fistula, Dabat district, Ethiopia
Biological Affinity and Sex Determination Using Morphometric and Morphoscopic Variables from the Human Mandible

I am submitting herewith a dissertation written by Gregory Eugene Berg entitled ―Biological Affinity and Sex Determination Using Morphometric and Morphoscopic Variables of the Human Mandible. ‖ I have examined the final electronic copy of this dissertation for form and content and recommend that it be accepted in partial fulfillment of the requirements for the degree of Doctor of Philosophy with a major in Anthropology.
Smoking behaviour and age

Aim: This study was aimed to evaluate age-related differences in smoking habits and to determine the different characteristics of the patients older than 65 years. Method: Information regarding demographic characteristics, comorbidities, and smoking history were obtained. The Hooked on Nicotine Checklist (HONC) questionnaire and the Fagerstrom Nicotine Dependence Test (NDT), were administered. Results: This study included a total of 140 patients with a mean age of 51.5±14.1 who presented to the smoking cessation unit between 2016-18. The age of onset for cigarette smoking was 16.9±5.1 years; the mean total smoking amount was 32.8±15.8 packs/year. 51(36.4%) patients were ≥65 years of age and 89 (63.6%) were Conclusion: Smoking is associated with male gender, a lower educational level, and a higher smoking rate above 65 years of age. These patients have a higher autonomy over smoking; they tried to quit smoking and used drugs more often. The rate of living with other smokers at home and at work is low. Patients over 65 years of age have different characteristics and treatments should be evaluated differently.
Identification of the Type of Human Papillomavirus (HPV) in Patients with Cervical Cancer

Human Papillomavirus (HPV) is the most significant risk factor for the cause of cervical cancer. The purpose of this study for identification of HPV types 16, 18, 31, 33, 45 and 52 in cervical cancer patients. HPV is a row of high-risk HPV types that can cause cervical cancer. Total sample of 78 diisolat DNA derived from FFPE, cervical smears and cervical cancer fresh tissue obtained from Dr. Dr. M. Djamil, Padang and hospitals. Arifin Achmad, Pekanbaru. HPV DNA detection is done by using Polymerase Chain Reaction (PCR) using universal primers GP5 +/6 +. HPV types were identified by PCR with specific primers. Total sample types obtained with concentrations varying between 0.9 to 645 ng / ml with purity DNA in accordance with the specified purity for PCR amplification. The results of the study of 78 patients with cervical cancer samples, 42 samples (54%) identified HPV DNA. HPV type 18 is more dominant and followed by HPV type 16 as compared to the other types, namely the percentage of 40.4% and 28.5%. HPV type 45 (7.1%), HPV type 52 (2.3%) and HPV 31 and HPV type 33 was not detected.
A phase II, double-blind study of galunisertib+gemcitabine (GG) vs gemcitabine+placebo (GP) in patients (pts) with unresectable pancreatic cancer (PC).

4019Background: In vivo preclinical models, transforming growth factor-beta (TGFβ) inhibitors enhanced gemcitabine activity. In this study, patients (pts) with Stage II to IV unresectable PC were treated with GG or GP to evaluate their efficacy and safety. Methods: Pts were randomized 2:1 (stratified for ECOG PS, disease stage and previous gemcitabine use) to GG or GP. Oral galunisertib 150 mg BID was given as intermittent dosing (14 days on/14 days off per cycle); gemcitabine was administered per label. The primary endpoint was overall survival (OS). Using a Bayesian augmented control (BAC) design assuming a hazard ratio (HR) of 0.7 for OS, the study had 90% power to identify if the probability of HR 0.85. Secondary endpoints included progression-free survival (PFS), overall response rate (ORR), biomarkers and safety (CTCAE v4). Results: 156 pts were randomized to GG (N = 104) or GP (N = 52). Baseline characteristics were balanced between groups. HR based on BAC was 0.8 with 95% credible interv.
Training and Preparedness to Meet the Needs of Students with a Chronic Health Condition in the School Setting

Despite the increasing prevalence of chronic health conditions among youth in schools, teachers report little exposure to specific coursework focusing on how to best support students with these conditions in the classroom. This study examined how teacher preparation programs prepare educators to meet the needs of this growing student population; findings also include survey results describing level of preparation to support students with a chronic health condition from the perspective of preservice and practicing educators enrolled in the nation’s leading colleges of education. Results suggest that dedicated curriculum to prepare teachers to work with students with chronic health conditions is largely absent from teacher preparation programming, and that teachers feel they lack knowledge to adequately support students with a chronic health condition in the classroom setting. Recommendations and implications are discussed.
Impacts of Psychological Distress, Gender Role Attitude, and Housekeeping Sharing on Quality of Life of Gynecologic Cancer Survivors.

PURPOSE To determine impacts of psychological distress, gender role attitude, and housekeeping sharing on quality of life of gynecologic cancer survivors. METHODS Subjects completed questionnaires consisting of four measurements: FACT-G (ver. 4) for quality of life, anxiety and depression from SCL-90-R for psychological distress, gender role attitude, and housekeeping sharing. A total of 158 completed data sets were analyzed by descriptive statistics, independent t-test, ANOVA, Pearson's correlation coefficient, and multiple regression analysis using SPSS 21.0 program. RESULTS Quality of life was significantly and negatively correlated with psychological distress (r=-0.64, p < .001), but not with gender role attitude (r=-0.14, p=.820) or housekeeping sharing (r=0.08, p=.350). Psychological distress was significantly and positively correlated with gender role attitude (r=0.25, p < .010). Factors that significantly impacted quality of life were type of cancer (t=2.27, p=.025), number of treatment methods (t=2.58, p=.011), education level (t=3.33, p < .001), and psychological distress (t=-9.96, p < .001). CONCLUSION Nursing interventions that can relieve psychological distress need to be developed for gynecologic cancer survivors. Nurses need to put priority on ovarian cancer survivors who have low education level with multiple treatment methods when performing nursing interventions to improve the quality of life of gynecologic cancer survivors.
Landbouw en zorg in de provincie. Inventarisatie van provinciaal beleid landbouw en zorg

Om zicht te krijgen op de verschillende beleidsplannen en stimuleringsregelingen van de provincies en om een indruk te krijgen van het resultaat van die beleidsmatige activiteiten, is een inventarisatie uitgevoerd van de beleidsactiviteiten van alle provincies in Nederland. Per hoofdstuk worden de provincies besproken. In het laatste hoofdstuk worden knelpunten besproken waar meerdere provincies tegen aan lopen en worden modellen en fasen van beleidsontwikkeling beschreven
Search Results: Predicting Ranking Algorithms With User Ratings and User-Driven Data

Search Results: Predicting Ranking Algorithms With User Ratings and User-Driven Data by Gary Michael Taylor MS, West Virginia University, 2010 BS, Marshall University, 2006 Doctoral Study Submitted in Partial Fulfillment of the Requirements for the Degree of Doctor of Information Technology Walden University February 2020 Abstract The purpose of this correlational quantitative study was to examine the possible relationship between user-driven parameters, user ratings, and ranking algorithms. The study’s population consisted of students and faculty in the information technology (IT) field at a university in Huntington, WV. Arrow’s impossibility theorem was used as the theoretical framework for this study. Complete survey data were collected from 47The purpose of this correlational quantitative study was to examine the possible relationship between user-driven parameters, user ratings, and ranking algorithms. The study’s population consisted of students and faculty in the information technology (IT) field at a university in Huntington, WV. Arrow’s impossibility theorem was used as the theoretical framework for this study. Complete survey data were collected from 47 students and faculty members in the IT field, and a multiple regression analysis was used to measure the correlations between the variables. The model was able to explain 85% of the total variability in the ranking algorithm. The overall model was able to significantly predict the algorithm ranking discounted cumulative gain, R = . 852, F(3,115) = 220.13, p < . 01. The Respondent DCG and Search term variables were the most significant predictor with p = . 0001. The overall findings can potentially be useful to content providers who focus their content on a specific niche. The content created by these providers would most likely be focused entirely on that subgroup of interested users. While it is necessary to focus content to the interested users, it may be beneficial to expand the content to more generic terms to help reach potential new users outside of the subgroups of interest. User’s searching for more generic terms could potentially be exposed to more content that would generally require more specific search terms. This exposure with more generic terms could help users expand their knowledge of new content more quickly. Search Results: Predicting Ranking Algorithms With User Ratings and User-Driven Data by Gary Michael Taylor MS, West Virginia University, 2010 BS, Marshall University, 2006 Doctoral Study Submitted in Partial Fulfillment of the Requirements for the Degree of Doctor of Information Technology Walden University February 2020
Enterprise Resource Planning Systems Implementation and Firm Performance: An Empirical Study

Adopting an ERP system is a challenge for any firm and the problems associated with it initially often negatively affect the adopting firm’s profitability as measured through a firm’s main financial indicators. Also for a longer period of time after implementation the empirical results on adoption are mixed, although more positive results have been reported in recent years. However, over the many years of implementing ERP systems much knowledge has been gained on how to improve the implementation process and speeding up the realization of the benefits. This research investigates whether Pakistani manufacturing firms profited from this by realizing the financial benefits early on. This is empirically tested by comparing ten financial performance indicators of firms that adopted an ERP system to that of non-adopters between 2002 and 2012. The results show that they benefitted from the start, but not in all areas.
Individual difference on reading ability tested by eye-tracking: from perspective of gender

This paper aims to investigate the individual difference on digital reading, by examining the eye-tracking records of male and female readers with different reading ability (including their pupil size, blink rate, fixation rate, fixation duration, saccade rate, saccade duration, saccade amplitude and regression rate). ,A total of 74 participants were selected according to 6,520 undergraduate students’ university entrance exam scores and the follow-up reading assessments. Half of them are men and half are women, with the top 3% good readers and the bottom 3% poor readers, from different disciplines. ,Results indicated that the major gender differences on reading abilities were indicated by saccade duration, regression rate and blink rate. The major effects on reading ability have a larger effect size than the major effect on gender. Among all the indicators that have been examined, blink rate and regression rates are the most sensitive to the gender attribute, while the fixation rate and saccade amplitude showed the least sensitiveness. ,This finding could be helpful for user modeling with eye-tracking data in intelligent tutoring systems, where necessary adjustments might be needed according to users’ individual differences. In this way, instructors could be able to provide purposeful guidance according to what the learners had seen and personalized the experience of digital reading.
Factors Influencing Intention to Use Web 2.0 in Indonesian Vocational High Schools

e-learning based on Web 2.0 applications is widely available for education to support teaching and learning efficiency and effectiveness. The objective of this research is to examine factors influencing teachers’ intention to use of Web 2.0 into teaching in Indonesian Vocational High Schools (VHSs) using Technology Acceptance Model (TAM) and Technological Pedagogical Content Knowledge (TPACK) frameworks. Based on these two frameworks, we developed a survey instrument and validated it through face and content validity. For the data analysis, we applied exploratory factorial analyses (EFA). To assess the model, a covariance-based structural equation modeling (CB-SEM) was used. The study involved 640 respondents who completed 35 online instrument items of seven validated variables. Results informed that there was a significant difference based on gender regarding intention to use Web 2.0; however, no significant differences were informed based on age and teaching subject. Besides, the findings also informed that TPACK, subjective norm, and facilitating condition significantly influenced intention to use Web 2.0.
A study of sexual dysfunction and its associated factors among women in childbearing age, Egypt

Background and objective: Sexual dysfunction is a significant public health problem that is more common among women than in men. The women sexual dysfunction and the factors influencing it have not yet been fully investigated. Aim: The present study aimed to evaluate sexual dysfunction and its associated factors among women in childbearing age, Egypt.Methods: A population-based cross-sectional survey involving 780 non-pregnant sexual active females aged 15-51 years old who were recruited into the study by random sampling. The study population was selected from health facilities which affiliated to the ministry of health in Damietta Governorate. Interview tools used to collect data related to female and male partner.Results: A total of 780 women in childbearing age were enrolled. More than half of the studied women have sexual dysfunction versus 46.9% without sexual function. 22.3% of sexual dysfunction women have mild dysfunction, 18.5% of them have moderate dysfunction, and 12.3% have severe dysfunction. Desire disorder was the most common sexual disorder among participants (67.3%), followed by arousal disorder (55.8%). There was a statistically significant correlation between female sexual dysfunction and husband's age, educational level and husbands suffer from depression, heavy smokers and hypnotic drugs used. Female sexual dysfunction was found among older age, low educated and non-workers females, as well as women, suffer chronic disease, genital inflammation, and stress.Conclusions: Sexual dysfunction is prevalent among women, so further study based on a comprehensive survey is necessarily needed.
More Tools for the Synthesist’s Toolbag in Harris Cooper’s Research Synthesis and Meta-Analysis: A Step-by-Step Approach (4th ed.)

The need for research synthesis grows along with the volume of contemporary published scholarship. Reporting such synthesis warrants rigorous guidelines for preparing these important, information-rich documents that make statements concerning the state of knowledge about a topic, gaps in knowledge, or the aggregation or integration of primary research. Cooper’s revised and expanded fourth edition of Research Synthesis and MetaAnalysis: A Step-by-Step Approach (2010) provides these needed guidelines with special attention given to the threats to validity at all steps of the research synthesis process.
Cephalometric Comparison of Treatment with Twin Block Appliance in Skeletal Class II Div 1 Patients with Normal and Vertical Growth Pattern

Regarding the effects of increase in vertical dimension on the outcomes of treatment with functional appliances, this study was designed to evaluate the differences between the outcome of treatment with twin block appliance in patients with normal and vertical growth pattern. This prospective cohort study was done by counting all (census) method so any patient with class II malocclusion due to mandibular deficiency was entered to the study with an informed consent. Each subject had immediate pre-post treatment lateral cephalograms. There were 11 patients in normal (FMA≤28) & 16 patients in vertical (FMA>28) group. Pre-post treatment lateral cephalograms were digitized and analyzed by Dolphin Imaging software. The data were then subjected to Paired t test & ANKOVA analysis. There was a statistically significant (p<0.05) reduction in overjet, U1-NA, U1-SN, ANB in both groups. Patients with normal growth pattern show a statistically significant (p<0.05) increase in L1-NB, AFH & IMPA. In patients with vertical growth pattern a statistically significant (p<0.05) increase in SNB, L1-NB, Co-Go, Co-Gn, AFH, PFH, PFH/AFH, LAFH & ANS-PNS can be mentioned. In comparison between two groups, there was statistically no significant difference in any variable after treatment. Twin block appliance is effective in correcting skeletal class II malocclusion and there is statistically no significant difference in any variable after treatment between two groups.
MODELLING OF DYNAMIC ASPECTS OF OPERATION IN RAILWAY VEHICLE TRACTION DRIVE SYSTEM INCLUDING THE ELECTROMECHANICAL COUPLING

In this paper, the influence of electromechanical interaction in an electric motor on the railway vehicle driving system dynamics was investigated. This is the train driven by DC. In particular, there is considered influence of electromagnetic field between a rotor and stator on excitation of resonant torsional vibrations of the drive system. Conclusions drawn from the computational results can be very useful during the design phase of these devices as well as helpful for their users during regular maintenance.