Miracle-dz/UniFAR-FTUs huggingface dataset:
Impact of Non-Saccharomyces Wine Yeast Strains on Improving Healthy Characteristics and the Sensory Profile of Beer in Sequential Fermentation

The use of non-Saccharomyces yeasts in brewing is a useful tool for developing new products to meet the growing consumer demand for innovative products. Non-Saccharomyces yeasts can be used both in single and in mixed fermentations with Saccharomyces cerevisiae, as they are able to improve the sensory profile of beers, and they can be used to obtain functional beers (with a low ethanol content and melatonin production). The aim of this study was to evaluate this capacity in eight non-Saccharomyces strains isolated from Madrid agriculture. For this purpose, single fermentations were carried out with non-Saccharomyces strains and sequential fermentations with non-Saccharomyces and the commercial strain SafAle S-04. The Wickerhamomyces anomalus strain CLI 1028 was selected in pure culture for brewing beer with a low ethanol content (1.25% (v/v)) for its fruity and phenolic flavours and the absence of wort flavours. The best-evaluated strains in sequential fermentation were CLI 3 (Hanseniaspora vineae) and CLI 457 (Metschnikowia pulcherrima), due to their fruity notes as well as their superior bitterness, body, and balance. Volatile compounds and melatonin production were analysed by GC and HPLC, respectively. The beers were sensory-analysed by a trained panel. The results of the study show the potential of non-Saccharomyces strains in the production of low-alcohol beers, and as a flavour enhancement in sequential fermentation.
Effect of cutting parameters on surface roughness in turning of annealed AISI-1020 steel

This study focuses on the effects of cutting parameters such as cutting speed ( Vc ), feed rate ( f ), and depth of cut ( d ) on roughness induced on the surface of annealed AISI 1020 steel when machined by turning using carbide insert tools. The results indicated that surface roughness increased when feed rate increased and cutting speed decreased. Depth of cut slightly influenced roughness. Analysis of variance and multiple regression techniques were used to formulate a quantitative equation for estimating predicted values of roughness as functions of the cutting parameters. The results showed that cutting speed is the most influencing parameter on surface roughness (69.35%), followed by feed rate (30.13%), while depth of cut failed to affect the responses substantially (0.52%). The proposed model can be used to select the optimum parameters for minimum surface roughness in metal turning.
CLK2 Expression Is Associated with the Progression of Colorectal Cancer and Is a Prognostic Biomarker

Background CLK2 is a splicing regulator and expressed ubiquitously in various malignancies. The study is aimed at exploring the potential roles of CLK2 in the development of colorectal cancer (CRC). Methods Real-time PCR and analyses of The Cancer Genome Atlas (TCGA) and Human Protein Atlas (HPA) database were utilized to evaluate the CLK2 gene transcription level and protein level of colorectal cancer (CRC) tissue. The chi-squared and logistic regression tests were used to evaluate the relationship between CLK2 and clinicopathologic features. Kaplan-Meier survival curve and Cox regression analysis were performed to explore the prognostic significance of CLK2. The association between CLK2 expression and immune landscapes was explored by CIBERSORT and ESTIMATE. Furthermore, GSEA (Gene Set Enrichment Analysis) and alternative splicing (AS) analyses were performed to investigate the relationship between CLK2 expression and downstream signaling pathway. Results The CLK2 expression was upregulated in CRC in both transcript and protein level. The elevated expression of CLK2 was correlated with local invasion and poor prognosis. Furthermore, CLK2 induced tumor cell adhesion and thereby promotes local invasion of CRC. The CLK2 expression significantly inhibited plasma cells and eosinophil infiltration and showed no relationship with immune and stromal scores of CRC samples. CLK2 might involve in Notch signaling pathway by regulating the AS of CTBP1. Conclusions CLK2 might be a potential prognostic biomarker and therapeutic target for colorectal cancer.
Factors Influencing Self-Confidence and Willingness to Perform Cardiopulmonary Resuscitation among Working Adults—A Quasi-Experimental Study in a Training Environment

Background: There is a potential relationship between the self-confidence and the willingness of bystanders to undertake resuscitation (CPR) and its training. The current guidelines increasingly focus on both the importance of the human factor and the fact that training programs should increase the willingness of bystanders to undertake resuscitation, which may have a direct impact on improving survival in out-of-hospital cardiac arrest (OHCA). Aim: The objective of the study was to analyze factors influencing the assessment of own skills crucial in basic life support (BLS) and the willingness to provide CPR to individual victims. Methods: A pre-test and post-test quasi-experimental design was used in this study. The data was collected from 4 December 2019 to 3 October 2020 in workplaces, during instructor-led BLS courses. Each intervention (training) consisted of a theoretical and a practical part. The program was focused both on the skills and the human factor. Results: Comparison of pre-test and post-test data concerning self-confidence scores of the ability to recognize OHCA among 967 participants demonstrated a significant difference (respectively, Me = 2.2, IQR [2–3] vs. Me = 3.4, IQR [3–4]; p = 0.000). Additionally, self-assessment scores for the ability to perform proper chest compressions between pre-test and post-test also differed significantly (respectively Me = 2.3, IQR [2–3] vs. Me = 3.3, IQR [3–4]; p = 0.000). A highly significant difference was found in the likelihood of changing the decision in favor of the willingness to undertake CPR for all types of victims, with the greatest difference found in relation to the willingness to conduct resuscitation on strangers (OR = 7.67, 95% CI 5.01–11.73; p < 0.01). Conclusions: Completing hands-on training has a highly significant, beneficial effect on the readiness to undertake resuscitation for all types of victims, strangers in particular. Training programs should place particular emphasis on developing readiness to undertake resuscitation for both those who have never been trained and those who had their last training more than one year ago.
FACTORS AFFECTING THE ADOPTION INTENTION MOBILE PAYMENT OF OVO IN SURABAYA

Background: Provide an adequate background covering the literature review and the gap of the research with other relevant former research works. Aim: This study aims to determine the Factors Affecting Adoption Intention to OVO Mobile Payment Users in Surabaya. Method: This type of research is basic business research using a quantitative approach with data analysis in the form of SEM (Structural Equation Model). Management of data in this study using AMOS 22.0 for windows which are used in testing the Measurement Model (Outer Model) and Structural Model (Inner Model). The sampling technique used is 300 respondents with the last education of SMK/SMA and have used m-payment OVO in the last 6 months and who are domiciled in Surabaya. Findings: The results showed that Perceived Transaction Convenience (PCT), Compatibility (COM), Relative Advantage (RA), Government Support (GS), Additional Value (AV), Perceived Risk (PSR), Absorptive Capacity (AC), Affinity (AFFI), and Personal Innovativeness in Information Technology (PIIT) is proven to have a significant effect on Adaptation Intention (AI). In addition, Social Influence (SI) has been shown to have non-significant results on the Adaptation Intention (AI) of OVO mobile payment users in Surabaya.
Trip durations of daily and seasonal foraging activities in Mischocyttarus nomurae (Richards) (Hymenoptera, Vespidae)

The study of foraging activity in wasps is important to understand the social organization and its evolutionary success. We examined aspects of the daily and seasonal foraging activities of Mischocyttarus nomurae Richards wasps, in terms of individual trip durationin the collection of different resources. The study was undertaken in two areas in the municipality of Rio de Contas, Bahia State, Brazil. Observations were done for 10 colonies of M. nomurae in their post-emergence phase under natural conditions, five during the rainy period and five during the dry period. The amplitudes of the activity hours were similar between the two periods. The foraging efficiency index was higher (80.56%) during the rainy period than during the dry period (74.42%), with greater percentages of returns with all foraged items (with the exception of prey captures). Temperature influenced positively and significantly the number of trips performed during the rainy period, while temperature and luminosity positively influenced the number of trips performed during the dry period. The mean duration of trips for diferente resources were greater during the dry period (with the exception of wood pulp), although those differences were not statistically significant. Wasps spent the most part of their time nectar (83.60 min), followed by prey (21.06 min), and wood Pulp (1.40 min). We observed that 52.56% of the foraging individuals of M. nomurae collected only a single resource type.
Self-reported oral hygiene habits and gingival bleeding in women with breast cancer: evidence from an observational and prospective study

Objectives: to describe and examine oral hygiene habits and self-reported gingival bleeding in women with breast cancer undergoing chemotherapy. Methods: in an observational and prospective study, 140 women were evaluated during chemotherapy between 2017 and 2019. Results and Conclusion: more than 40% of participants reported gingival bleeding at some point during chemotherapy. Flossing was unsatisfactory at baseline and in the intermediate cycle as well as did not affect self-reported gingival bleeding. The amount of tooth brushing per day was a predictor of self-reported gingival bleeding at the end of chemotherapy.
Estimativas da cobertura de mamografia segundo inquéritos de saúde no Brasil

OBJETIVO: Inqueritos populacionais constituem ferramenta fundamental para monitorar a cobertura de mamografia e os fatores associados a sua realizacao. Em inqueritos baseados na populacao residente em domicilios com telefone as estimativas tendem a ser superestimadas. O estudo teve por objetivo estimar a cobertura de mamografia com base em pesquisas de base populacional. METODOS: A partir das coberturas por mamografia em mulheres de 50 a 69 anos, com e sem telefone fixo, observadas na Pesquisa Nacional por Amostra de Domicilios (PNAD) 2003, calcularam-se as razoes entre elas e o respectivo coeficiente de variacao. A razao de cobertura foi multiplicada pela cobertura estimada pelo sistema de Vigilância de Fatores de Risco e Protecao para Doencas Cronicas por Inquerito Telefonico (VIGITEL), permitindo estimar a cobertura entre mulheres sem telefone em 2007. Essas estimativas foram aplicadas a populacao de mulheres, com e sem telefone, obtidas a partir da PNAD 2006, obtendo-se assim as estimativas finais para as capitais. RESULTADOS: Em 2007, para o conjunto das capitais, estimou-se a cobertura de mamografia em aproximadamente 70%, variando de 41,2% em Porto Velho (RO) a 82,2% em Florianopolis (SC). Em 17 municipios a cobertura foi maior que 60%; em oito, de 50%-60%; e em dois, a cobertura foi inferior a 50%. Em termos absolutos, a diferenca entre as coberturas do VIGITEL e as estimadas foi de 6,5% para o conjunto dos municipios, variando de 3,4% em Sao Paulo (SP) a 24,2% em Joao Pessoa (PB). CONCLUSOES: As diferencas nas magnitudes das estimativas da cobertura de mamografia por inqueritos populacionais sao em grande parte reflexo dos desenhos dos estudos. No caso especifico da mamografia, seria mais apropriado estimar sua cobertura combinando dados do VIGITEL com aqueles de outros inqueritos, que incluam informacoes sobre mulheres com e sem telefone fixo, especialmente em municipios de baixa cobertura de telefonia fixa.
The effect of international opportunity recognition processes on problem-solving competence: how does past negative entrepreneurial experience matter?

Research background: Little research addresses how identifying an opportunity in the international market, whether through active search or serendipitous discovery, may have implications for the subsequent gestation behaviors. An emerging body of research suggests addressing this deficiency by focusing on the cognitive and experience-based factors that international entrepreneurs use to develop an opportunity in the foreign market once identified. Purpose of the article: The aim of this study is to explore the role of active and serendipitous international opportunity recognition (IOR) in entrepreneurs? problem-solving skills (problem-solving speed and creativity), as well as the moderating effect of past negative entrepreneurial experience (PNE) on such relationships. Methods: This study used the survey data collection method through an online self-administered questionnaire. Partial least square structural equation modeling (PLS-SEM) method was used to analyze the results over a sample of Spanish international entrepreneurs. Findings & value added: The results show that entrepreneurs that have identified an international opportunity (IO) actively are better equipped to solve problems speedily than those that have discovered an IO serendipitously. In contrast, entrepreneurs who identified an IO serendipitously are better equipped to solve problems creatively. Furthermore, the impact of active search on problem-solving speed is greater for entrepreneurs without PNE, and the impact of active search on problem-solving creativity is greater for entrepreneurs with PNE. Also, it is found that PNE does not moderate serendipitous IOR relationship with problem-solving competence. These findings are relevant as they indicate that the IOR processes have implications for the subsequent gestation behaviors. Thus, the value added of this study is the combination of cognitive and experience-based factors of the international entrepreneur to enrich the link between IOR processes and IO development. These are two intertwined and interdependent processes, which, however, have been scarcely studied as a whole. The results of this research help international entrepreneurs to understand how and why the way they recognized an IO and having or not PNE influence their problem-solving skills during the IO development phase.
The Effect of Multimedia Teaching Intervention on Physical Education Curriculum on University Students� Sports Attitudes and Sports Behaviors

Background. World Health Organization pointed out in 2019 that insufficient physical activity has become the fourth major risk factor affecting global mortality. Objectives. This research explores the influence of multi-media teaching intervention in the physical education curriculum on college students’ sports attitudes and behavior. Methods. The subjects of weight training and Yogalates courses (94 people in weight training class 2 and 94 people in Yogalates class 2) were divided into experimental and control groups. Both groups were taught in person for 18 weeks. The experimental group participated in multi-media audio-visual teaching for 6 weeks, once a week, for 30 minutes. The control group did not implement multi-media audio-visual teaching. Before and after the teaching experiment, 188 questionnaires were issued with the sports attitude and sports behavior scales, and 184 (97.8%) were effectively returned in the pre-test; 180 (95.7%) were effectively returned in the post-test. After the questionnaire was collected, it was analyzed by descriptive statistics, cross-analysis, and an independent sample t-test. Results. The study found that after multi-media teaching is involved in physical education courses, students’ sports attitudes and behaviors are significantly higher than in traditional teaching, and the number of students participating in sports after class has increased significantly. Conclusion. Multi-media teaching intervention in physical education courses can effectively improve students’ attitudes towards sports, change their actual participation in sports, and enable students to develop the habit of continuing to participate in sports after class.
THE INFLUENCE OF SITUATIONAL LEADERSHIP AND ORGANIZATIONAL CULTURE MODERATED BY COMPENSATION ON EMPLOYEE PERFORMANCE

The development of the retail business is quite rapid and followed by very fierce competition , causing PT Midi Utama Indonesia Tbk. Palu Branch needs to maintain a competitive advantage to remain competitive with other companies. Employees become one of the important resources to maintain a competitive advantage. Therefore, improving employee performance is required at all times, where changes occur so quickly and are difficult to predict. This study aimed at analyzing the influence of situational leadership and organizational culture moderated by compensation on employee performance. Respondents in this study were 108 office employees using the saturated sample technique (Census) in determining the sample. The data collection method uses a questionnaire and is analyzed using SEM-PLS. The results of this study show that situational leadership has an insignificant positive direct influence on employee performance. Likewise, the effect of a positive interaction is insignificant between compensation and situational leadership on employee performance. Meanwhile, organizational culture has a positive and significant effect directly on employee performance. The effect of the interaction of compensation and organizational culture proved to be positive and significant in influencing employee performance. The company is expected to maintain a clan culture that prioritizes teamwork and collaborativeity. Furthermore, the application of more flexible leadership according to the conditions and situations faced by the company needs to be optimized. In the end, the provision of indirect financial compensation needs to be improved so that it can strengthen the improvement of employee performance.
Identification of Endoplasmic Reticulum Stress-Related Subtypes, Infiltration Analysis of Tumor Microenvironment, and Construction of a Prognostic Model in Colorectal Cancer

Simple Summary Understanding how endoplasmic reticulum stress influences colorectal cancer progression and the composition of the tumor microenvironment is important for developing novel strategies in the treatment of colorectal cancer. In this study, we identified two endoplasmic reticulum stress-related subtypes of colorectal cancer with distinct prognosis and infiltration patterns in the tumor microenvironment. Besides, we constructed a prognostic model for predicting patients’ survival, which involved an endoplasmic reticulum stress-related 14-gene signature. Furthermore, by utilizing spatial transcriptomics data from two untreated colorectal cancer patients, we explored endoplasmic reticulum stress-related gene signatures at a subcellular level and found that colorectal cancer cells and regulatory T cells showed an evidently increased expression of endoplasmic reticulum stress-related gene signature, and cancer-associated fibroblasts might be the leading characteristic that distinguishes the endoplasmic reticulum stress-related subtypes of colorectal cancer. We suggest that targeting endoplasmic reticulum stress in colorectal cancer might reshape the exhausted tumor microenvironment and mitigate tumor progression. Abstract Recently, endoplasmic reticulum (ER) stress has been shown to influence tumor progression and immune cell function in the tumor microenvironment (TME). However, the underlying role of ER stress-related gene patterns in colorectal cancer (CRC) development remains unclear. We analyzed the ER stress-related gene patterns in 884 patients with CRC from the Gene Expression Omnibus database and evaluated the cell-infiltrating patterns in the TME. Two ER stress-related patterns were identified in patients with CRC that had distinct cell-infiltrating patterns in the TME and clinical characteristics. A risk score and nomogram based on 14 screened prognosis-correlated genes was built and validated to predict patient survival. Patients with a higher risk score were shown to have an unfavorable prognosis, and the risk score was associated with cell infiltration and drug sensitivity. Furthermore, spatial transcriptomics data were utilized to explore ER stress-related gene patterns in CRC tissues, and it was shown that ER stress phenotype involves in the formation of the immunosuppressive TME. This study demonstrated that ER stress-related gene patterns play a role in influencing the TME and predicting prognosis. These analyses of ER stress in the TME of CRC might deepen our understanding of CRC progression and immune escape and provide novel insights into therapeutic strategies.
Decision Support Application for Energy Consumption Forecasting

Energy consumption forecasting is crucial in current and future power and energy systems. With the increasing penetration of renewable energy sources, with high associated uncertainty due to the dependence on natural conditions (such as wind speed or solar intensity), the need to balance the fluctuation of generation with the flexibility from the consumer side increases considerably. In this way, significant work has been done on the development of energy consumption forecasting methods, able to deal with different forecasting circumstances, e.g., the prediction time horizon, the available data, the frequency of data, or even the quality of data measurements. The main conclusion is that different methods are more suitable for different prediction circumstances, and no method can outperform all others in all situations (no-free-lunch theorem). This paper proposes a novel application, developed in the scope of the SIMOCE project (ANI|P2020 17690), which brings together several of the most relevant forecasting methods in this domain, namely artificial neural networks, support vector machines, and several methods based on fuzzy rule-based systems, with the objective of providing decision support for energy consumption forecasting, regardless of the prediction conditions. For this, the application also includes several data management strategies that enable training of the forecasting methods depending on the available data. Results show that by this application, users are endowed with the means to automatically refine and train different forecasting methods for energy consumption prediction. These methods show different performance levels depending on the prediction conditions, hence, using the proposed approach, users always have access to the most adequate methods in each situation.