Miracle-dz/UniFAR-FTUs huggingface dataset:
Elevated limb-bud and heart development (LBH) expression indicates poor prognosis and promotes gastric cancer cell proliferation and invasion via upregulating Integrin/FAK/Akt pathway

The limb-bud and heart development (LBH) gene is a highly conserved, tissue-specific transcription cofactor in vertebrates that regulates multiple key genes in embryonic development. The role of LBH in various cancer types is still controversial, and its specific role and molecular mechanism in the oncogenesis of gastric cancer (GC) remains largely unexplored. In the present study, the prognostic significance and clinicopathological characteristics of LBH in GC was determined. The LBH mRNA expression was first investigated in four independent public datasets (TCGA-STAD, GSE15459, GSE29272, and GSE62254) and then validated with our samples at the protein level. LBH was overexpressed at both the mRNA and protein levels in cancer compared with normal tissues. High LBH expression was correlated with advanced T, N, and M stages. Kaplan–Meier analysis and log-rank test indicated that higher LBH expression was statistically correlated with shorter overall survival (OS) in the public datasets and our study samples. Univariate and multivariate Cox regression analysis showed that LBH was an independent prognostic biomarker for survival in TCGA-STAD, GSE15459, GSE62254 cohorts, and our GC patients. In vitro experiments showed that knockdown of LBH can significantly inhibit the proliferation and invasion of HGC-27 cells, while overexpression of LBH can significantly enhance the proliferation and invasion of BGC-823 cells. Gene Set Enrichment Analysis (GSEA), Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomics (KEGG) indicated that high LBH expression is associated with the PI3K-Akt pathway, focal adhesion, and extracellular matrix (ECM)-receptor interaction. Western blot analysis showed that knockdown of LBH significantly inhibited the expression of integrin α5, integrin β1, p-FAK, and p-Akt. Therefore, results from the present study indicate that LBH is a potential independent prognostic biomarker and promotes proliferation and invasion of GC cells by activating the integrin/FAK/Akt pathway.
Numerical Simulation of Rapid Erosion of Seisho Coast Triggered by Storm Waves during Typhoon 0709

On September 6, 2007, the Seisho Bypass extending along the Seisho coast was severely damaged over a length of 1.1 km owing to storm waves associated with Typhoon 0709, resulting in roads being closed to traffic for urgent repairs. During the typhoon, severe beach erosion occurred owing to both strong offshore sand transport and westward longshore sand transport by storm waves, and the foreshore was rapidly narrowed. However, the foreshore was recovered except the damaged area of the highway as a result of the effect of normal waves. These beach changes were predicted using the contour-line-change model incorporating Fukuhama et al.'s concept. The predicted results were in good agreement with the measured beach changes.
Ozone observations by the Gas and Aerosol Measurement Sensor during SOLVE II

The Gas and Aerosol Measurement Sensor (GAMS) was deployed aboard the NASA DC-8 aircraft during the second SAGE III Ozone Loss and Validation Experiment (SOLVE II). GAMS acquired line-of-sight (LOS) direct solar irradiance spectra during the sunlit portions of ten science flights of the DC-8 between 12 January and 4 February 2003. Differential line-of-sight (DLOS) optical depth spectra are produced from the GAMS raw solar irradiance spectra. Then, DLOS ozone number densities are retrieved from the GAMS spectra using a multiple linear regression spectral fitting technique. Both the DLOS optical depth spectra and retrieved ozone data are compared with coincident measurements from two other solar instruments aboard the DC-8 platform to demonstrate the robustness and stability of the GAMS data. The GAMS ozone measurements are then utilized to evaluate the quality of the Wulf band ozone cross sections, a critical component of the SAGE III aerosol, water vapor, and temperature/pressure retrievals. Results suggest the ozone cross section compilation of Shettle and Anderson currently used operationally in SAGE III data processing may be in error by as much as 10–20% in the Wulf bands, and their lack of reported temperature dependence is a significant deficiency. A second, more recent, cross section database compiled for the SCIAMACHY satellite mission appears to be of much better quality in the Wulf bands, but still may have errors as large as 5% near the Wulf band absorption peaks, which is slightly larger than their stated uncertainty. Additional laboratory measurements of the Wulf band cross sections should be pursued to further reduce their uncertainty and better quantify their temperature dependence.
The Mediating Role of Work-related Musculoskeletal Disorders on the Relationship between Psychosocial Factors and Presenteeism among Administrative Workers

—In a highly demanding working environment, the problem of work-related musculoskeletal disorders (WRMDs) is getting more serious as compared to previous days. This phenomenon brings significant negative effect on the productivity of the employees. Therefore, the present study was conducted to investigate the factors that contribute to the prevalence of WRMDs and to examine the influence of WRMDs on employees' presenteeism. Analyzing a total of 368 responses collected from the administrative employees, the findings indicate that the prevalence of WRMDs among administrative workers includes neck disorder (67.1%), shoulders' disorder (73.4%), upper-back disorder (70.1%) and wrists/hands' disorder (41.0%). The study also found that shoulders' and upper-back disorders partially mediate the relationship between social support and personal risk factors and presenteeism, neck and wrists/hands' disorders serve as partial mediators in the relationship between personal risk factors and presenteeism. The implication of the study is discussed.
Towards controlled self-organized behavioral exploration

Self-organizing (SO) systems have the capabilities to induce low-dimensional global behavior in a high-dimensional system, for instance in bird flocks or ant colonies. These systems tend to be resilient under changeable conditions or to malfunction of individual parts. In the case of agents’ behavior, the self-organization relies on the embodied interaction with the environment and exploits physical effects. These properties make it natural to aim for the application of a self-organizing method to robot development. A difference between the prominent SO systems and a robot is that it consists of a single component instead of many largely independent components. In order to obtain a self-organized behavioral development, a guiding principle is required. One of the prominent principles is Homeokinesis – balancing activity and predictability. The maximization of the predictive information (PI) [1] is another such principle that was also cast into a online algorithm [3]. Although these methods lead to self-organization of behavior in a large variety of robots, the principle has an inherent disadvantage of constantly increasing the complexity of the behavior. As an effect the system aims for behaviors with maximal attractor dimension, see [5]. However, natural behavior such as walking, crawling, reaching, etc. are low-dimensional. Conceptually, it might be a question of timescales. If a succession of low-dimensional behaviors is generated then on a longer time-scale the predictive information can potentially also be maximized. Nevertheless, for direct behavior generation, it may ultimately not be suitable. Recently the differential extrinsic plasticity (DEP) [2] learning rule was proposed, which originated from a simplification of the PI rule. It leads to the emergence of low-dimensional behaviors in different systems. Examples are a humanoid robot starting to crawling, turn a wheel or a hexapod robot to locomote [2]. Applied to a real tendon driven anthropomorphic arm the learning rule led to the SO development of bottle swinging, and shaking, table wiping and wheel turning, just due to the brain-body-environment coupling [4]. The DEP rule creates a dynamics with a multitude of attractors. Depending on the body and environmental conditions different attractor behaviors are reached. These can be switched by perturbations. However, a systematic understanding is still missing. In this contribution we provide a first analysis of DEP rule and propose a method to obtain a systematic sweep through the behavior landscape.
Telehealth for Acute and Chronic Care Consultations

• Results vary by setting and condition, with telehealth consultations producing generally either better outcomes or no difference from comparators in settings and clinical indications studied. – Remote intensive care unit consultations likely reduce mortality. – Specialty telehealth consultations likely reduce patient time in the emergency department. – Telehealth consultations in emergency services likely reduce heart attack mortality. – Remote consultations for outpatient care likely improve access and clinical outcomes.
Estrutura e análise zoogeográfica de uma taxocenose de morcegos no norte do Estado do Amazonas, Brasil

During an epidemiological survey along the middle course of rio Negro, in the western periphery of Guyana subregion, a survey of bats was conducted in the municipalities of Barcelos and Santa Isabel do Rio Negro, State of Amazonas, Brazil. Fieldworks conducted from 1998 to 2004 resulted in the capture of 36 bat species distributed in 27 genera and six families. Phyllostomidae accounted for the largest number of species and individuals, Phyllostominae being the most speciose, and Stenodermatinae the most abundant. The analysis of species distribution patterns and comparisons with lists for other Amazonian localities indicate that the assemblage reported here is almost entirely composed for species widely distributed in different zoogeographical Amazonian provinces, occurring yet in other Neotropical rainforests. Thus, it appears that the assemblage reported here is comprised almost entirely of the commonest species in the Amazon region, highlighting the need for the increase of sampling effort with mist nets in the understory and canopy and search for roosts.
Resetting of the U–Pb Zircon System in Cambro-Ordovician Intrusives of the Deep Freeze Range, Northern Victoria Land, Antarctica

A detailed in situ isotopic (U^Pb, Lu^Hf) and geochemical study of zircon populations in a composite sequence of foliated to massive Cambro-Ordovician intrusions in the Deep Freeze Range (NorthVictoria Land, Antarctica), has highlighted great complexity in zircon systematics. Zircons in deformed granitoids and tonalites display complex internal textures, a wide spread of concordant U^Pb ages (between 522 and 435Ma) and unusual trace-element compositions (anomalous enrichment of light rare earth elements, U,Th and Y) within single zircon grains. In contrast, zircons from undeformed samples display a limited range of U^Pb ages and traceelement compositions. Zircons from all age and textural populations in most of the deformed and undeformed samples show a relatively narrow range of Hf values, suggesting that the Lu^Hf system remained undisturbed. Inferred emplacement ages cover a time interval of about 30Myr: from 508 to 493Ma for the oldest strongly foliated synkinematic Howard Peaks megacrystic monzogranites and high-K calc-alkaline mafic to intermediate rocks of the ‘Corner Tonalite’ unit; from about 489 to 481Ma for the younger massive shoshonitic mafic dyke suite and the high-K calc-alkaline Keinath granite.The observed isotopic and chemical variations in zircon are attributed to a sub-solidus recrystallization under hydrous conditions and varying temperature, in a setting characterized by a transpressional to extensional stress regime.
Effect of Football Shoe Collar Type on Ankle Biomechanics and Dynamic Stability during Anterior and Lateral Single-Leg Jump Landings

In this study, we investigated the effects of football shoes with different collar heights on ankle biomechanics and dynamic postural stability. Fifteen healthy college football players performed anterior and lateral single-leg jump landings when wearing high collar, elastic collar, or low collar football shoes. The kinematics of lower limbs and ground reaction forces were collected by simultaneously using a stereo-photogrammetric system with markers (Vicon) and a force plate (Kistler). During the anterior single-leg jump landing, a high collar shoe resulted in a significantly smaller ankle dorsiflexion range of motion (ROM), compared to both elastic (p = 0.031, dz = 0.511) and low collar (p = 0.043, dz = 0.446) types, while also presenting lower total ankle sagittal ROM, compared to the low collar type (p = 0.023, dz = 0.756). Ankle joint stiffness was significantly greater for the high collar, compared to the elastic collar (p = 0.003, dz = 0.629) and low collar (p = 0.030, dz = 1.040). Medial-lateral stability was significantly improved with the high collar, compared to the low collar (p = 0.001, dz = 1.232). During the lateral single-leg jump landing, ankle inversion ROM (p = 0.028, dz = 0.615) and total ankle frontal ROM (p = 0.019, dz = 0.873) were significantly smaller for the high collar, compared to the elastic collar. The high collar also resulted in a significantly smaller total ankle sagittal ROM, compared to the low collar (p = 0.001, dz = 0.634). Therefore, the high collar shoe should be effective in decreasing the amount of ROM and increasing the dynamic stability, leading to high ankle joint stiffness due to differences in design and material characteristics of the collar types.
A re-examination of herzenbergite–teallite solid solution at temperatures between 300 and 700°C

Abstract In order to investigate the range of the solid solution series in herzenbergite-teallite minerals, samples of different composition were synthesized. Herzenbergite-teallite minerals were synthesized by an evacuated silica glass tube method at 700°C. A linear relationship between cell dimensions, a, b and c and composition is established. Extension of solid solution to the Pb-rich portion of the system PbS-SnS is limited; the solid solution area is between Pb1.060Sn0. 940S2 and SnS at 700°C. Teallite coexisting with galena was also synthesized by hydrothermal recrystallization at 300, 400 and 450°C. The compositions of teallite are Pb1.140Sn0. 860S2 at 300°C, Pb1.114Sn0. 886S2 at 400°C, and Pb1.124Sn0. 876S2 at 450°C, respectively. Their compositions shift towards the PbS end-member from stoichiometric teallite. The cell dimensions of teallite, which was synthesized hydrothermally, follow the linear relationship between cell dimensions and composition established at 700°C.
Frequency‐dependent anisotropy due to fluid flow in bed limited cracks

Evidence from a number of measurements support the idea that anisotropy, or shear wave splitting, exhibits a frequency dependence. This is generally attributed to properties of the microstructure of the rock and typically assumed to be the result of scattering from oriented inclusions within the rock mass. However, there are a number of competing mechanisms that may give rise to this observed frequency dependence. The scale length of the inclusions must be much smaller than the wavelength at which the measurements were conducted, in order for their presence to be observed as an effective anisotropy, and may therefore be insufficient to account for a significant frequency dependence from scattering. An alternative mechanism resulting in frequency dependence is the transfer of fluid between the inclusions, assumed to be fluid filled. Using a recently developed model, it is demonstrated that this fluid effect is potentially significant enough to explain observed frequency dependence.
The Consequences of Abortion and Contraception Policies on Young Women's Reproductive Choices, Schooling and Labor Supply

I specify a dynamic life-cycle model of abortion, contraceptive use, schooling, and labor supply decisions of US women. I structurally estimate the model, allowing for abortion misreporting, using from the NLSY97, aggregate abortion provider data from the Guttmacher Institute, and information on mandatory counseling restrictions at the state level. I simulate a series of policies and find that eliminating access to abortion services increases contraceptive use but decreases women’s schooling and lifetime earnings. I also find that providing free contraception would increase contraceptive use and decrease abortion rates substantially, while also leading to an increase in women’s schooling.
Generalizations of Kempe's universality theorem

In 1876, A. B. Kempe presented a flawed proof of what is now called Kempe’s Universality Theorem: that the intersection of a closed disk with any curve in R defined by a polynomial equation can be drawn by a linkage. Kapovich and Millson published the first correct proof of this claim in 2002, but their argument relied on different, more complex constructions. We provide a corrected version of Kempe’s proof, using a novel contraparallelogram bracing. The resulting historical proof of Kempe’s Universality Theorem uses simpler gadgets than those of Kapovich and Millson. We use our two-dimensional proof of Kempe’s theorem to give simple proofs of two extensions of Kempe’s theorem first shown by King: a generalization to d dimensions and a characterization of the drawable subsets of R. Our results improve King’s by proving better continuity properties for the constructions. We prove that our construction requires only O(n) bars to draw a curve defined by a polynomial of degree n in d dimensions, improving the previously known bounds of O(n) in two dimensions and O(n) in three dimensions. We also prove a matching Ω(n) lower bound in the worst case. We give an algorithm for computing a configuration above a given point on a given polynomial curve, running in time polynomial in the size of the dense representation of the polynomial defining the curve. We use this algorithm to prove the coNP-hardness of testing the rigidity of a given configuration of a linkage. While this theorem has long been assumed in rigidity theory, we believe this to be the first published proof that this problem is computationally intractable. This thesis is joint work with Reid W. Barton and Erik D. Demaine. Thesis Supervisor: Erik D. Demaine Title: Esther & Harold Edgerton Associate Professor
Sillimanite deformation mechanisms within a Grt-Sil-Bt gneiss: effect of pre-deformation grain orientations and characteristics on mechanism, slip-system activation and rheology

Abstract Sillimanite-bearing metapelites are common in the middle to lower crust and play an important role in the rheology of these crustal levels. We report deformation microstructures in a metasedimentary gneiss (Greenland) produced during simple shear at c. 700 °C and c. 4.5 kbar. Electron backscatter diffraction analysis shows activation of the (001)[010] and (001)[100] slip systems in large grains. Additionally, (100)[001] and (010)[001] are activated in needles with their c-axes parallel to lineation. Medium-grained sillimanite aggregates mixed with biotite show a weak crystallographic preferred orientation (CPO) suggesting activation of (001)[010] and (001)[100] together with grain boundary sliding (GBS). GBS is the dominant deformation mechanism in the outer parts of fine-grained clusters of sillimanite stemming from andalusite replacement. Associated features are phase mixing, clockwise dispersion of c-axis orientations and change of misorientation axes from original c-axis rotation to rotation close to the kinematic Y axis. The latter features which result in strain localization around these clusters allow their ‘preservation’. Rheologically, the medium-grained aggregates together with zones around clusters take up most of the deformation. Our study shows that deformation mechanism and slip-system activation, and CPOs are strongly dependent on the orientation relationship between stress axes and pre-deformation grain orientations and characteristics.
Geotechnical parameters from VP and VS measurements in unsaturated soils

This paper presents a simple procedure for evaluating the coefficients of volume change of unsaturated soils from measurements of the shear and dilatational wave velocities. The procedure is based on some analytical expressions that have been derived in the present study using the theory of linear elasticity for low-frequency excitations. The soil parameters required as input are the porosity and degree of saturation of the soil, Poisson's ratio of the soil skeleton, and three physical parameters that generally assume constant values. The results of some applications of the proposed method to a set of experimental data published in the literature are also shown.
Classification and comparison of natural and altered flow regimes to support an Australian trial of the Ecological Limits of Hydrologic Alteration framework

The Ecological Limits of Hydrologic Alteration (ELOHA) is a new framework designed to develop environmental flow prescriptions for many streams and rivers in a user‐defined geographic region or jurisdiction. This study presents hydrologic classifications and comparisons of natural and altered flows in southeast Queensland, Australia, to support the ecological steps of a field trial of the ELOHA framework. We extended existing protocols for flow classification by assessing the stability of flow classes. Model‐based clustering distinguished six Reference classes (based on modelled pre‐development flow data) and five Historic classes (based on stream gauge data). The principal flow regime change was loss of some of the original (natural) flow diversity accompanied by the emergence of a perennial flow class in the Historic classification composed mostly of gauges with flow regimes influenced by dams. However, similarities between Reference and Historic classifications indicate that hydrologic changes in southeast Queensland have not totally obscured Reference (pre‐development) characteristics. Duration of low flow spells has undergone the greatest absolute change from Reference values.