Miracle-dz/UniFAR-FTUs huggingface dataset:
Steering witnesses for unknown Gaussian quantum states

We define and fully characterize the witnesses based on second moments detecting steering in Gaussian states by means of Gaussian measurements. All such tests, which arise from linear combination of variances or second moments of canonical operators, are easily implemented in experiments. We propose also a set of linear constraints fully characterizing steering witnesses when the steered party has one bosonic mode, while in the general case the constraints restrict the set of tests detecting steering. Given an unknown quantum state we implement a semidefinite program providing the appropriate steering test with respect to the number of random measurements performed. Thus, it is a ‘repeat-until-success’ method allowing for steering detection with less measurements than in full tomography. We study the efficiency of steering detection for two-mode squeezed vacuum states, for two-mode general unknown states, and for three-mode continuous variable GHZ states. In addition, we discuss the robustness of this method to statistical errors.
Vision Transformers, a new approach for high-resolution and large-scale mapping of canopy heights

Accurate and timely monitoring of forest canopy heights is critical for assessing forest dynamics, biodiversity, carbon sequestration as well as forest degradation and deforestation. Recent advances in deep learning techniques, coupled with the vast amount of spaceborne remote sensing data offer an unprecedented opportunity to map canopy height at high spatial and temporal resolutions. Current techniques for wall-to-wall canopy height mapping correlate remotely sensed 2D information from optical and radar sensors to the vertical structure of trees using LiDAR measurements. While studies using deep learning algorithms have shown promising performances for the accurate mapping of canopy heights, they have limitations due to the type of architectures and loss functions employed. Moreover, mapping canopy heights over tropical forests remains poorly studied, and the accurate height estimation of tall canopies is a challenge due to signal saturation from optical and radar sensors, persistent cloud covers and sometimes the limited penetration capabilities of LiDARs. Here, we map heights at 10 m resolution across the diverse landscape of Ghana with a new vision transformer (ViT) model optimized concurrently with a classification (discrete) and a regression (continuous) loss function. This model achieves better accuracy than previously used convolutional based approaches (ConvNets) optimized with only a continuous loss function. The ViT model results show that our proposed discrete/continuous loss significantly increases the sensitivity for very tall trees (i.e.,>35m), for which other approaches show saturation effects. The height maps generated by the ViT also have better ground sampling distance and better sensitivity to sparse vegetation in comparison to a convolutional model. Our ViT model has a RMSE of 3.12m in comparison to a reference dataset while the ConvNet model has a RMSE of 4.3m.
Applications of Information Inequalities to Database Theory Problems

The paper describes several applications of information inequalities to problems in database theory. The problems discussed include: upper bounds of a query’s output, worst-case optimal join algorithms, the query domination problem, and the implication problem for approximate integrity constraints. The paper is self-contained: all required concepts and results from information inequalities are introduced here, gradually, and motivated by database problems.
A similarity‐based cross‐language comparison of basicness and demarcation of “blue” terms

To investigate linguistic and perceptual boundaries within the “blue” region of the color gamut, we analyzed sorting data from speakers of six languages who sorted color stimuli by similarity. Two of these languages, Russian and Italian, are thought to have a separate basic color term and category for “light blue,” distinguishing it from “blue,” and the third was English, which lacks this distinction. There has been less study of the possible basicness of “light blue” terms in the other three languages: Lithuanian and Estonian (both spoken in Baltic states) and Udmurt (a linguistic enclave in North Russia). Sorting data from each sample of speakers were analyzed with principal component analysis and multidimensional scaling, reducing them to a pattern of interstimulus similarities. In addition, color-naming data were collected for five of the languages and confirmed that sorting responses were not simply a reflection of the words used by subjects to label the stimuli. A “clustering index” was created, quantifying the extent of light/dark blue separation and the strength of any category boundary between them; this was low for English-language participants but high for Russian and Italian. Udmurt and Lithuanian values were also high, whereas Estonian responses were closer to English. Thus, when clustering of blue stimuli is used as an additional indicator of basicness, the results are compatible with earlier evidence that “light blue” is a separate basic color category in Russian and Italian, and further indicate that light blue terms are basic in Udmurt and Lithuanian, but not Estonian. It may be that “blue” categories are especially susceptible to splitting into two under the influence of linguistic contact. © 2016 Wiley Periodicals, Inc. Col Res Appl, 2016
Racial disparities among candidemic patients at a Southern California teaching hospital

Abstract Racially and ethnically minoritized (REM) patients are disproportionately affected by infectious diseases, including candidemia. REM patients with candidemia were significantly younger, with trends toward more risk factors for candidemia and longer lengths of stay. Although Candida parapsilosis was more common in REM patients, there were no differences in mortality rates.
Osteopontin promotes age-related adipose tissue remodeling through senescence-associated macrophage dysfunction

Adipose tissue macrophages (ATMs) play an important role in obesity and inflammation, and they accumulate in adipose tissue (AT) with aging. Furthermore, increased ATM senescence has been shown in obesity-related AT remodeling and dysfunction. However, ATM senescence and its role are unclear in age-related AT dysfunction. Here, we show that ATMs (a) acquire a senescence-like phenotype during chronological aging; (b) display a global decline of basic macrophage functions such as efferocytosis, an essential process to preserve AT homeostasis by clearing dysfunctional or apoptotic cells; and (c) promote AT remodeling and dysfunction. Importantly, we uncover a major role for the age-associated accumulation of osteopontin (OPN) in these processes in visceral AT. Consistently, loss or pharmacologic inhibition of OPN and bone marrow transplantation of OPN–/– mice attenuate the ATM senescence-like phenotype, preserve efferocytosis, and finally restore healthy AT homeostasis in the context of aging. Collectively, our findings implicate pharmacologic OPN inhibition as a viable treatment modality to counter ATM senescence-mediated AT remodeling and dysfunction during aging.
A Systematic Review Looking at Anodyspareunia Among Cisgender Men and Women

Abstract This systematic review aims to provide an up-to-date evaluation of the available literature on anodyspareunia and treatment interventions. It aims to identify research gaps and to evaluate treatment methods in psychosexual healthcare services. Electronic searches including PubMed, PsycINFO, Web of Science, and registered clinical trials yielded 8 studies. Research centered on men who have sex with men (MSM) and cisgender women with a 3:1 ratio. In terms of causes of anodyspareunia, correlates among both MSM and cisgender women included generalized anxiety, performance anxiety, compromised well-being, lack of stimulation, lack of lubrication, and lack of sexual arousal. While research has focused on anodyspareunia among cisgender gay men, limited research has targeted other genders or sexualities including heterosexual men and lesbian and bisexual women. No research was found on intersex, transgender, and gender nonconforming people. Similarly, there were no articles that discussed or evaluated treatment strategies. The findings of this review demonstrate the paucity of research on both the condition of anodyspareunia and its treatment across genders and sexually diverse groups. Both quantitative and qualitative research would not only develop our understanding of anodyspareunia but also contribute to public health through the development of suitable treatment interventions.
Design and statistical optimisation of emulsomal nanoparticles for improved anti-SARS-CoV-2 activity of N-(5-nitrothiazol-2-yl)-carboxamido candidates: in vitro and in silico studies

Abstract In this article, emulsomes (EMLs) were fabricated to encapsulate the N-(5-nitrothiazol-2-yl)-carboxamido derivatives (3a–3g) in an attempt to improve their biological availability and antiviral activity. Next, both cytotoxicity and anti-SARS-CoV-2 activities of the examined compounds loaded EMLs (F3a–g) were assessed in Vero E6 cells via MTT assay to calculate the CC50 and inhibitory concentration 50 (IC50) values. The most potent 3e-loaded EMLs (F3e) elicited a selectivity index of 18 with an IC50 value of 0.73 μg/mL. Moreover, F3e was selected for further elucidation of a possible mode of action where the results showed that it exhibited a combination of virucidal (>90%), viral adsorption (>80%), and viral replication (>60%) inhibition. Besides, molecular docking and MD simulations towards the SARS-CoV-2 Mpro were performed. Finally, a structure–activity relationship (SAR) study focussed on studying the influence of altering the size, type, and flexibility of the α-substituent to the carboxamide in addition to compound contraction on SARS-CoV-2 activity. Highlights Emulsomes (EMLs) were fabricated to encapsulate the N-(5-nitrothiazol-2-yl)-carboxamido derivatives (3a–3g). The most potent 3e-loaded EMLs (F3e) showed an IC50 value of 0.73 μg/mL against SARS-CoV-2. F3e exhibited a combination of virucidal (>90%), viral adsorption (>80%), and viral replication (>60%) inhibition. Molecular docking, molecular dynamics (MD) simulations, and MM-GBSA calculations were performed. Structure–activity relationship (SAR) study was discussed to study the influence of altering the size, type, and flexibility of the α-substituent to the carboxamide on the anti-SARS-CoV-2 activity. GRAPHICAL ABSTRACT
Uncertainty and sensitivity analysis of runoff and sediment yield in a small agricultural watershed with KINEROS2 / Analyse d'incertitude et de sensibilité des simulations d'écoulement et de transport solide de KINEROS2 dans un petit bassin versant agricole

Abstract Using the Monte Carlo (MC) method, this paper derives arithmetic and geometric means and associated variances of the net capillary drive parameter, G, that appears in the Parlange infiltration model, as a function of soil texture and antecedent soil moisture content. Approximate expressions for the arithmetic and geometric statistics of G are also obtained, which compare favourably with MC generated ones. This paper also applies the MC method to evaluate parameter sensitivity and predictive uncertainty of the distributed runoff and erosion model KINEROS2 in a small experimental watershed. The MC simulations of flow and sediment related variables show that those parameters which impart the greatest uncertainty to KINEROS2 model outputs are not necessarily the most sensitive ones. Soil hydraulic conductivity and wetting front net capillary drive, followed by initial effective relative saturation, dominated uncertainties of flow and sediment discharge model outputs at the watershed outlet. Model predictive uncertainty measured by the coefficient of variation decreased with rainfall intensity, thus implying improved model reliability for larger rainfall events. The antecedent relative saturation was the most sensitive parameter in all but the peak arrival times, followed by the overland plane roughness coefficient. Among the sediment related parameters, the median particle size and hydraulic erosion parameters dominated sediment model output uncertainty and sensitivity. Effect of rain splash erosion coefficient was negligible. Comparison of medians from MC simulations and simulations by direct substitution of average parameters with observed flow rates and sediment discharges indicates that KINEROS2 can be applied to ungauged watersheds and still produce runoff and sediment yield predictions within order of magnitude of accuracy.
FIRST THREE YEARS OF THE MICROWAVE RADIOMETER ABOARD ENVISAT : IN-FLIGHT CALIBRATION, PROCESSING AND VALIDATION OF THE GEOPHYSICAL PRODUCTS

Abstract The Envisat microwave radiometer is designed to correct the satellite altimeter data for the excess path delay resulting from tropospheric humidity. Neural networks have been used to formulate the inversion algorithm to retrieve this quantity from the measured brightness temperatures. The learning database has been built with European Centre for Medium-Range Weather Forecasts (ECMWF) analyses and simulated brightness temperatures by a radiative transfer model. The in-flight calibration has been performed in a consistent way by adjusting measurements on simulated brightness temperatures. Finally, coincident radiosonde measurements are used to validate the Envisat wet-tropospheric correction, and this comparison shows the good performances of the method.
Quantum Geometry of the Ising Model

We introduce some modern mathematical and theoretical tools in 2dimensional physics, and apply them to the Ising model. We rederive some well-known results, but also some new properties of this important model. All the tools presented here have applications for beyond the Ising model. We explore several aspects of conformal field theory, proving, analysing, and testing Zamolodchikov’s C-theorem. We explore finite size effects in critical and non-critical systems on the cylinder and the torus, and discuss the implications of modular invariance. Using BCFT, we explore the implications for theories with a boundary, and look at an interesting relationship between BCFTs and non-critical theories for integrable models, which indicates that there is a deep link between conformal symmetry and the symmetry of integrability. Finally we explore the holographic projection of critical and off-critical models which relates flat 2-dimensional models to 3-dimensional gravity.
Clinical significance of long non‐coding RNA ZEB2‐AS1 and EMT‐related markers in ductal and lobular breast cancer

Breast cancer is considered the most prevalent type of cancer in women and accounts for a high rate of death. A body of research has demonstrated that lncRNAs have a regulatory function in human diseases, especially cancers. ZEB2‐AS1 is known as an oncogenic lncRNA in various types of cancers, and its deregulation may contribute to cancer development and progression. Therefore, we aimed to reveal the association of ZEB2‐AS1 expression with epithelial–mesenchymal transition (EMT) markers, as a hallmark of cancer progression, in a clinical setting.
Penicillin-Binding Protein Occupancy Dataset for 18 β-Lactams and 4 β-Lactamase Inhibitors in Neisseria gonorrhoeae

The manuscript represents the first N. gonorrhoeae PBP-binding data set for 22 chemically different drugs in two type strains with different genetic background. We have identified three clusters of drugs according to their PBP binding IC50s and highlighted the binding differences across the two strains studied. ABSTRACT The lack of effective first-line antibiotic treatments against Neisseria gonorrhoeae, and the worldwide dissemination of resistant strains, are the main drivers of a worsening global health crisis. β-lactam antibiotics have been the backbone of therapeutic armamentarium against gonococci. However, we are lacking critical insights to design rationally optimized therapies. In the present work, we generated the first PBP-binding data set on 18 currently available and clinically relevant β-lactams and 4 β-lactamase inhibitors in two N. gonorrhoeae ATCC type collection strains, 19424 and 49226 (PBP2 type XXII and A39T change in mtrR). PBP binding (IC50) was determined via the Bocillin FL binding assay in isolated membrane preparations. Three clusters of differential PBP IC50s were identified and were mostly consistent across both strains, but with quantitative differences. Carbapenems were coselective for PBP2 and PBP3 (0.01 to 0.03 mg/L). Third- and fourth-generation cephalosporins cefixime, cefotaxime, ceftazidime, cefepime, and ceftriaxone showed the lowest IC50 values for PBP2 (0.01 mg/L), whereas cefoxitin, ceftaroline, and ceftolozane required higher concentrations (0.04 to >2 mg/L). Aztreonam was selective for PBP2 in both strains (0.03 to 0.07 mg/L); amdinocillin bound this PBP at higher concentrations (1.33 to 2.94 mg/L). Penicillins specifically targeted PBP2 in strain ATCC 19424 (0.02 to 0.19 mg/L) and showed limited inhibition in strain ATCC 49226 (0.01 to >2 mg/L). Preferential PBP2 binding was observed by β-lactam-based β-lactamase inhibitors sulbactam and tazobactam (1.07 to 6.02 mg/L); meanwhile, diazabicyclooctane inhibitors relebactam and avibactam were selective for PBP3 (1.27 to 5.40 mg/L). This data set will set the bar for future studies that will help the rational use and translational development of antibiotics against multidrug-resistant (MDR) N. gonorrhoeae. IMPORTANCE The manuscript represents the first N. gonorrhoeae PBP-binding data set for 22 chemically different drugs in two type strains with different genetic background. We have identified three clusters of drugs according to their PBP binding IC50s and highlighted the binding differences across the two strains studied. With the currently available genomic information and the PBP-binding data, we have been able to correlate the target attainment differences and the mutations that affect the drug uptake with the MIC changes. The results of the current work will allow us to develop molecular tools of great practical use for the study and the design of new rationally designed therapies capable of combating the growing MDR gonococci threat.
Return to Sport in Middle-aged and Older Athletes After Unicompartmental Knee Arthroplasty at a Mean 10-Year Follow-up: Radiographic and Clinical Outcomes

Background: Return to sport is essential information when an athlete contemplates surgical intervention. Young athletes, <30 years of age, may undergo complex cartilage procedures or femoral/tibial osteotomies to successfully treat single-compartment knee osteoarthritis. Unicompartmental knee arthroplasty (UKA) may offer an attractive alternative option to middle-aged/older athletes with timely return to the same sport without a lengthy rehabilitation. Purpose: The purpose of this study was to determine if athletes are able to return to the same level of vigorous and moderate sports after fixed-bearing intramedullary nonrobotic UKA and the specific sports activities that these athletes continued to participate in at a minimum of 5 years. We hypothesized that UKA in the appropriately selected middle-aged/older athlete would yield high return to sport after UKA with high patient satisfaction. We also hypothesized that UKA would allow athletes to return to their sports of choice. Study Design: Cohort study; Level of evidence, 3. Methods: We identified 245 patients who underwent a UKA by a single surgeon between 2003 and 2017. Athletes were included if they participated in vigorous or moderate sports, as defined by the American College of Sports Medicine, and had minimum 5-year follow-up. The primary outcome was return to vigorous or moderate sports after UKA. Secondary outcomes included the Knee injury and Osteoarthritis Outcome Score (KOOS) Activities of Daily Living score, KOOS Sport and Recreation score, Lysholm score, Patient Acceptable Symptom State (PASS) analysis, and radiographic analysis. Results: An overall 169 athletes met the inclusion criteria and were evaluated for return to sports. A total of 98% (165/169) returned to vigorous or moderate sports participation. The mean ± SD time to return to sport was 5.2 ± 2.3 months in the 39- to 50-year-old cohort, 5.8 ± 3.2 months in athletes aged 51 to 64 years, and 5.2 ± 3.0 months in athletes aged ≥65 years. A total of 143 athletes had minimum 5-year clinical and radiographic follow-up (mean, 10 years; range, 5-19 years). Maintenance of vigorous and moderate sport was seen in 99% (142/143) of athletes at a mean 10 years. In athletes who participated in vigorous sports, the mean Lysholm score was 85 ± 17, and 83% reached the PASS for KOOS Sport and Recreation. Radiographic analysis revealed no evidence of implant loosening (ie, subsidence, radiolucency) or osteolysis, and limb alignment and posterior slope of the implant were within normal limits. Conclusion: Athletes returned to sport at a mean 5 months after UKA implantation, with 98% (165/169) participating in vigorous or moderate sports. UKA is recommended as an alternative procedure in middle-aged and older athletes with single-compartment osteoarthritis who are contemplating a return to vigorous or moderate sport.
A Comparative Study of the Properties of Gelatin (Porcine and Bovine)-Based Edible Films Loaded with Spearmint Essential Oil

Gelatin (bovine/porcine)-based edible films are considered as an excellent carrier for essential oils (EOs) to preserve food quality and extend their shelf life. Spearmint essential oil (SEO) is known for its potential antioxidant and antimicrobial effects; nevertheless, its food applications are limited due to the volatile nature of its active components. Thus, edible films loaded with essential oil can be an alternative to synthetic preservatives to improve their food applications. In the present study, the effect of SEO addition was investigated on the physicochemical properties of bovine and porcine gelatin films, and antioxidant activity was assessed. GCMS (Gas chromatography mass spectrometry) analysis revealed the presence of carvone (55%) and limonene (25.3%) as major components. The incorporation of SEO into the films decreased the opacity, moisture content, water solubility, and elongation at break of bovine and porcine gelatin films. However, with the addition of EO, the thickness and water vapor permeability of bovine and porcine-based gelatin films increased. Moreover, the addition of SEO increased the tensile strength (TS) of the porcine-based film, whereas bovine samples demonstrated a decrease in tensile strength. XRD (X-ray diffraction) findings revealed a decrease in the percentage crystallinity of both types of gelatin films. SEM (scanning electron microscope) results showed the changes in the morphology of films after the addition of SEO. Antioxidant properties significantly increased with the incorporation of EO (p < 0.05) when compared with control films. Therefore, the addition of SEO to gelatin-based edible films could be an effective approach to prepare an active food packaging material to prevent food oxidation.
Impact of coronavirus disease 2019 on consumers’ perceptions of genetically modified food

ABSTRACT The coronavirus disease 2019 (COVID-19) pandemic has generated significant economic loss and an unprecedented challenge to people’s livelihoods. Using household data collected in November 2020, this study shows that the COVID-19 outbreak has significantly affected consumers’ perceptions and consumption of genetically modified (GM) food in China. Their perceptions and purchase intentions have turned more negative, and their actual purchase of GM food has decreased after the COVID-19 outbreak. The study’s results also indicate that consumers with more knowledge of genetic modification technology are less likely to change their perceptions of GM food.