Miracle-dz/UniFAR-FTUs huggingface dataset:
Risk Factors for Anemia Among Pregnant Women Attending the Antenatal Care Unit in Selected Jigjiga Public Health Facilities, Somali Region, East Ethiopia 2019: Unmatched Case–Control Study

Background Anemia is a significant public health concern in many developing countries, particularly during pregnancy, and it has adverse effects on mother and fetus/baby. Objective To determine the factors associated with anemia among pregnant women attending antenatal care in Jigjiga public health facilities, Somali Region, East Ethiopia. Methods An institution-based unmatched case–control study was conducted. The sample size was 228 pregnant women; comprising 114 presenting with anemia and 114 controls. Hemoglobin levels were measured using a portable heme analyzer. Socio-demographic, dietary, medical history, and nutrition-related data were collected using a structured questionnaire. Data were entered into Epidata 3.1 and exported to Statistical Package for the Social Sciences (SPSS) version 23.0 for cleaning and analyses. Bivariate and multivariate logistic regression was performed and statistical significance was considered at a level of p<0.05. Results Three predictors of anemia among pregnant women were identified in this study. An inadequate intake of red meat (i.e. those who consumed red meat 1–2 times a month [AOR=7.245; 95% CI=(2.007–26.151)] or not at all [AOR=8.690; 95% CI=(1.795–42.072)]), and insufficient consumption of green vegetables (i.e. 1–2 times a week [AOR=2.970; 95% CI=(1.012–8.716)] or 1–2 times a month [AOR=8.057; 95% CI=(2.358–27.526)]) were associated with anemia. Also, having a mid-upper arm circumference (MUAC) of less than 23 cm was strongly associated [AOR=16.432; 95% CI= (5.240–51.526)] with anemia. Conclusion This study revealed three key factors to be associated with anemia among pregnant women in Jigjiga Town, namely reduced intake of red meat and green vegetables, and low MUAC. Interventions including nutrition counselling and enrolling pregnant women with low nutritional status in nutritional programs should be the core components of anemia control strategies, needed to address the high prevalence of anemia during pregnancy in developing countries.
A Prospective, Randomized, Placebo-Controlled Study of a Combination of Simvastatin and Chemotherapy in Metastatic Breast Cancer

Preclinical studies support the anticancer activity of statins; however, the existing clinical evidence is inconsistent and not definitive. Our study aimed at evaluating a postulated cancer chemo-sensitizing effect of statin (simvastatin) in a cohort of metastatic breast cancer (MBC) patients. We designed a prospective, single-centered, randomized, double blinded, placebo-controlled trial that encompassed MBC patients with an ECOG Performance Status Scale ≤2 and scheduled to be treated with a chemotherapy regimen consisting of carboplatin and vinorelbine every 3 weeks at Al-Baironi Hospital, Damascus, Syria. Patients were enrolled between August 2011 and July 2012 and randomly allocated to receive a 15-day course of either simvastatin (40 mg) or placebo seven days prior to the first day of each chemotherapy cycle and then continued for eight days in each individual cycle. Primary endpoints were objective response rate (ORR) and toxicity, and the secondary endpoint was overall survival (OS). Eighty-two patients met the inclusion criteria and consented. ORR (35% vs. 32.5%) and predominant toxicity and grade ≥3 neutropenia (occurred in 30% vs. 40% of the patients) were not significantly different between simvastatin and placebo groups, respectively. Over a median follow-up of 44 months (range, 10–60), median OS was 15 months in the simvastatin group and 17 the in placebo group (hazard ratio (HR) = 1.16, 95% CI (0.70–1.91), P=0.57). Elevated baseline values of high-sensitivity C-reactive protein (hsCRP >10 mg/l), lactate dehydrogenase (LDH >480 U/L), and chemotherapy being ≥2nd line were significantly associated with shorter OS for the total cohort in both Univariate and multivariate analyses. Our data prove a safe profile of simvastatin at 40 mg per day combined with carboplatin and vinorelbine in MBC patients but without any beneficial increase of tumor sensitivity to chemotherapy. Moreover, we demonstrated a strong clinical advantage of baseline values of hsCRP and LDH as useful prognostic tools in MBC patients. This trial is registered with ISRCTN12964275.
Implementation of Pharmacogenetics to Individualize Treatment Regimens for Children with Acute Lymphoblastic Leukemia

Abstract Despite major advances in the management and high cure rates of childhood acute lymphoblastic leukemia (ALL), patients still suffer from many drug-induced toxicities, sometimes necessitating dose reduction, or halting of cytotoxic drugs with a secondary risk of disease relapse. In addition, investigators have noted significant inter-individual variability in drug toxicities and disease outcomes, hence the role of pharmacogenetics (PGx) in elucidating genetic polymorphisms in candidate genes for the optimization of disease management. In this review, we present the PGx data in association with main toxicities seen in children treated for ALL in addition to efficacy, with a focus on the most plausible germline PGx variants. We then follow with a summary of the highest evidence drug-gene annotations with suggestions to move forward in implementing preemptive PGx for the individualization of treatment regimens for children with ALL.
Wastewater Treatment by a Polymeric Bioflocculant and Iron Nanoparticles Synthesized from a Bioflocculant

Wastewater remains a global challenge. Various methods have been used in wastewater treatment, including flocculation. The aim of this study was to synthesize iron nanoparticles (FeNPs) using a polymeric bioflocculant and to evaluate its efficacy in the removal of pollutants in wastewater. A comparison between the efficiencies of the bioflocculant and iron nanoparticles was investigated. A scanning electron microscope (SEM) equipped with an energy-dispersive X-ray analyzer (EDX) and Fourier transform-infrared (FT-IR) spectroscopy were used to characterize the material. SEM-EDX analysis revealed the presence of elements such as O and C that were abundant in both samples, while FT-IR studies showed the presence of functional groups such as hydroxyl (–OH) and amine (–NH2). Fe nanoparticles showed the best flocculation activity (FA) at 0.4 mg/mL dosage as opposed to that of the bioflocculant, which displayed the highest flocculation activity at 0.8 mg/mL, and both samples were found to be cation-dependent. When evaluated for heat stability and pH stability, FeNPs were found thermostable with 86% FA at 100 °C, while an alkaline pH of 11 favored FA with 93%. The bioflocculant flocculated poorly at high temperature and was found effective mostly at a pH of 7 with over 90% FA. FeNPs effectively removed BOD (biochemical oxygen demand) and COD (chemical oxygen demand) in all two wastewater samples from coal mine water and Mzingazi River water. Cytotoxicity results showed both FeNPs and the bioflocculant as nontoxic at concentrations up to 50 µL.
New Method for Beat-to-Beat Fetal Heart Rate Measurement Using Doppler Ultrasound Signal

The most commonly used method of fetal monitoring is based on heart activity analysis. Computer-aided fetal monitoring system enables extraction of clinically important information hidden for visual interpretation—the instantaneous fetal heart rate (FHR) variability. Today’s fetal monitors are based on monitoring of mechanical activity of the fetal heart by means of Doppler ultrasound technique. The FHR is determined using autocorrelation methods, and thus it has a form of evenly spaced—every 250 ms—instantaneous measurements, where some of which are incorrect or duplicate. The parameters describing a beat-to-beat FHR variability calculated from such a signal show significant errors. The aim of our research was to develop new analysis methods that will both improve an accuracy of the FHR determination and provide FHR representation as time series of events. The study was carried out on simultaneously recorded (during labor) Doppler ultrasound signal and the reference direct fetal electrocardiogram Two subranges of Doppler bandwidths were separated to describe heart wall movements and valve motions. After reduction of signal complexity by determining the Doppler ultrasound envelope, the signal was analyzed to determine the FHR. The autocorrelation method supported by a trapezoidal prediction function was used. In the final stage, two different methods were developed to provide signal representation as time series of events: the first using correction of duplicate measurements and the second based on segmentation of instantaneous periodicity measurements. Thus, it ensured the mean heart interval measurement error of only 1.35 ms. In a case of beat-to-beat variability assessment the errors ranged from −1.9% to −10.1%. Comparing the obtained values to other published results clearly confirms that the new methods provides a higher accuracy of an interval measurement and a better reliability of the FHR variability estimation.
Absence of Adverse Effects of Tiotropium/Olodaterol Compared with the Monocomponents on Long-Term Heart Rate and Blood Pressure in Patients with Moderate-to-Very-Severe COPD

Introduction Long-acting β2-agonists (LABAs) and long-acting muscarinic antagonists (LAMAs) are established maintenance bronchodilator treatments for chronic obstructive pulmonary disease (COPD) with the potential to increase heart rate (HR) and impact blood pressure (BP). While previous studies indicate that HR and BP are not negatively influenced by tiotropium or olodaterol monotherapy, the effect of tiotropium/olodaterol has not been evaluated. We report a post hoc analysis of the effect of dual bronchodilation with tiotropium/olodaterol versus monocomponents on HR and BP in patients with moderate-to-very-severe COPD included in the large TONADO® study. Methods The TONADO® trials (1237.5 [NCT01431274] and 1237.6 [NCT01431287]) were two replicate, randomized, double-blind, parallel-group, 52-week, Phase III trials that compared tiotropium/olodaterol (5/5 μg and 2.5/5 μg) with tiotropium (5 μg and 2.5 μg) and olodaterol (5 μg) in patients with moderate-to-very-severe COPD. Patients with cardiovascular comorbidities were included. Changes in HR and systolic/diastolic BP were measured before and after dosing with the study medication at each visit (baseline, Week 12, Week 24 and Week 52). Results Overall, 3,100 patients were included in this analysis. Over 52 weeks, small changes from baseline in mean HR (<2 beats per minute [bpm]) and small changes from pre- to post-dose (<1 bpm) were evident at different time points. There was a non-significant increase from baseline in mean diastolic and systolic BP (<2 mmHg) observed over 52 weeks of treatment. The short-term (1 hour pre- to 1 hour post-dose) mean changes in systolic and diastolic BP over 52 weeks in the tiotropium/olodaterol 5/5 µg group were comparable with those observed for the monocomponents at all time points. Conclusion There were no differences in HR or BP among patients on tiotropium/olodaterol when compared with monocomponents. This supports the already demonstrated cardiovascular safety profile of tiotropium/olodaterol as long-acting maintenance bronchodilator treatment for COPD, including patients with cardiovascular comorbidities.
Transsphenoidal Optic Canal Decompression for Traumatic Optic Neuropathy Assisted by a Computed Tomography Image Postprocessing Technique

The endoscopic transethmoidal approach is favored for the lack of external scars, a wide field of view, and rapid recovery time. But the effect of iatrogenic trauma should not be ignored due to the removal of the uncinate process and anterior and posterior ethmoidal sinus. Anatomically, the optic nerve is close to the sphenoid sinus and Onodi cell. In order to preserve the uncinate process and ethmoidal sinus, we perform endoscopic transsphenoidal optic canal decompression (ETOCD), which is less invasive. However, the anatomy of sphenoid sinus is quite variable, and the anatomical landmarks are rare. Therefore, identifying the position of optic canal is particularly important during surgery. To solve this, we use a postprocessing technique to identify the position of the optic nerve and internal carotid artery on the sphenoid sinus wall. Our results find that VA in 13 patients improved, with a total improve rate of 59.1%. No serious complications were found. We also found that the length of optic canal is different and the medial wall of the optic canal was the longest (p < 0.05). The middle section of the optic canal is the narrowest, which was significantly different from cranial mouth and orbital mouth (p < 0.05). We assumed that decompression may not require removal of all medial wall. If we remove the length of the shortest wall on the medial wall of the optic canal, the compression may be relieved. Thus, ETOCD was a feasible, safe, effective, and less-invasive approach for patients with TON. The CT postprocessing imaging facilitated recognition of the optic canal during surgery. The decompression length of the medial wall may not need to be completely removed, especially near the cranial mouth.
Genetic Determination of Potential Trichoderma Species Using ISSR(Microsatellite) Marker in Uttar Pradesh, India

Seven Trichoderma sp. were collected from different locations of Uttar Pradesh, India for evaluating their bioefficiency by determining their genetic variations. PCR-based Inter Simple Sequence Regions (ISSR) Marker employing 6 primers produced 30 scorable bands out of which 27 bands were polymorphic. The Unweighted Pair Group Method of Arithmetic Means (UPGMA) dendrogram constructed from Nei’s [14] genetic distance produced 2 main clusters (1 isolates in cluster 1 and 6 isolates in cluster 2). The result indicating their genetic diversity has opened new possibility of using the most efficient and more isolates of Trichoderma in the preparation of effective biopesticide.
Time Perspectives and Delay of Gratification – The Role of Psychological Distance Toward the Future and Perceived Possibility of Getting a Future Reward

Purpose This study investigated how an individual’s time perspective of the present and the future affects the delay of gratification, using the construal level theory. In addition, the mechanisms that influence the time perspective on the delay of gratification were examined through the mediating roles of the psychological distance and the perceived possibility of getting a future reward. Participants and Methods One hundred twenty university students completed the Korean version of the Swedish Zimbardo Time Perspective Inventory (S-ZTPI) and performed a Temporal Discounting task to aid in the evaluation of their ability to delay gratification. Their psychological distance to the future and perceived possibility of getting a future reward were measured using the visual analogue scale. Results The results showed that once the Present-Hedonistic and Future-Negative from among the six-time perspectives increased, and the ability to delayed gratification decreased. On the other hand, once the Future-Positive time perspective increased, the ability to delayed gratification increased. Only the psychological distance for 9 months was associated with time perspective and the mediation effect was not significant. Present-Hedonistic time perspective negatively predicted the perceived possibility of getting a future reward and the delay of gratification. The perceived possibility of getting a future reward fully mediated the relation between the Future-Negative time perspective and the delay of gratification. Conclusion These findings suggest that problems involved with the delay of gratification (such as smoking, addiction, and binge eating behavior) are more likely to occur in people who have high Present-Hedonistic and Future-Negative time perspectives, because these time perspectives lead to a lower perceived possibility of getting a future.
Effect of Structure and Composition of Non-Stoichiometry Magnesium Aluminate Spinel on Water Adsorption

MgAl2O4 is used in humidity sensing and measurement, and as a catalyst or catalyst support in a wide variety of applications. For such applications, a detailed understanding of the surface properties and defect structure of the spinel, and, in particular, of the gas interactions at the spinel surface is essential. However, to the best of our knowledge, very limited experimental data regarding this subject is currently available. In this work, four spinel samples with an Al2O3 to MgO ratio (n) between 0.95 and 2.45 were synthesized and analyzed using X-ray photoelectron spectroscopy and water adsorption micro-calorimetry. The results showed that the spinel composition and its consequent defect structure do indeed have a distinct effect on the spinel-water vapor surface interactions. The adsorption behavior at the spinel-water interface showed changes that resulted from alterations in types and energetic diversity of adsorption sites, affecting both H2O uptake and overall energetics. Furthermore, changes in composition following appropriate thermal treatment were shown to have a major effect on the reducibility of the spinel which enabled increased water uptake at the surface. In addition to non-stoichiometry, the impact of intrinsic anti-site defects on the water-surface interaction was investigated. These defects were also shown to promote water uptake. Our results show that by composition modification and subsequent thermal treatments, the defect structure can be modified and controlled, allowing for the possibility of specifically designed spinels for water interactions.
An In Vitro Evaluation Study of the Geometric Changes of Root Canal Preparation and the Quality of Endodontic Treatment

Introduction The geometry of root canals differs in different parts, especially in the apical region, and it is affected by different preparation techniques. The aim of this study was to evaluate the geometric changes of root canal preparation by general dentists regardless of the endodontic instrumentation systems and to study the quality of endodontic treatment by evaluating the untouched areas after mechanical preparation and the smear layer removal. Materials and Methods 100 extracted maxillary canines were collected for the in vitro study from 10 dentists, and the dentists were asked to treat the teeth endodontically. The teeth then were separated and examined under an optical microscope to evaluate the root canal final diameter and the untouched areas. Then, the teeth were examined under a scanned electronic microscope to evaluate the smear layer in coronal, middle, and third parts of the canal. Statistical significance was set as P < 0.05. Results The mean diameter of the root canal after instrumentation in the coronal and middle thirds was 2.50 ± 1.12 and 1.75 ± 1.24 mm, respectively, and the untouched area percentage observed in the apical thirds was 71%. For smear layer removal, it was better in the coronal and middle thirds than in the apical (P < 0.05). Conclusion The changes in the diameter of the root canal, the percentage of untouched areas after mechanical preparation, and the percentage of smear layer were observed in a higher percent in the apical third than in the coronal and middle thirds, and this raises the question of changing the technique of processing the root canal, especially in the apical third.
Areas of Potential Improvement for Hospitals’ Patient-Safety Culture in Western Ethiopia

Background Patient-safety culture is an important component of health-care quality and currentlyan issue of high concern globally. In Ethiopia, little is known about patient-safety culture in hospitals. We assessed the patient-safety culture and associated factors among health-care workers in public hospitals of East Wollega Zone, western Ethiopia. Methods This institution-based cross-sectional study was conducted among 421 health-care workers selected using simple random sampling from March 4 to March 29, 2019. A standardized measuring 12 patient safety–culture components was used for data collection. Data were cleaned and entered into EpiData version 3.1 and analysis done using SPSS version 25 (IBM). Bivariate and multivariate linear regression analyses were performed. Significance was set at 95% CI and p<0.05, and unstandardized β-coefficients were used to measure extent of association. Results This study revealed that the level of patient-safety culture was 49.2% and patient safety culture–component scores ranged from 29.2% for nonpunitive responses to error to 77.9% for teamwork within a hospital unit. Age ≥45 years (β=13.642, CI: 5.324–21.959; p=0.001), 1–5 years’ experience at the current hospital (β=5.559, 95% CI 2.075–9.042; p=0.002), and working in general hospitals (β=11.988, 95% CI 7.233–16.743; p<0.001) and primary hospitals (β=6.408, 95% CI 2.192–10.624; p=0.003) were factors associated with better scores on patient-safety culture. Conclusion Overall scores for patient-safety culture were low. Improving the current state of patient safety in public hospitals would require tailored interventions to address low-scoring components, such as nonpunitive responses to error.
Protective Effect of Methylxanthine Fractions Isolated from Bancha Tea Leaves against Doxorubicin-Induced Cardio- and Nephrotoxicities in Rats

Doxorubicin is an anthracycline antibiotic that is used for the treatment of various types of cancer. However, its clinical usage is limited due to its potential life-threatening adverse effects, such as cardio- and nephrotoxicities. Nonetheless, simultaneous administration of doxorubicin and antioxidants, such as those found in green tea leaves, could reduce cardiac and renal tissue damage caused by oxidative stress. The methylxanthine fraction isolated from Bancha tea leaves were tested in vitro for its antioxidant activity and in vivo for its organoprotective properties against doxorubicin-induced cardio- and nephrotoxicities in a rat model. The in vivo study was conducted on male Wistar rats divided into 6 groups. Methylxanthines were administered at high (5 mg/kg body weight) and low (1 mg/kg body weight) doses, while doxorubicin was administered at a cumulative dose of 20 mg/kg body weight. Serum creatinine, uric acid, and urea concentrations, as well as serum enzyme levels (creatinine kinase (CK), creatinine kinase MB fraction (CK-MB), aspartate aminotransferase (AST), and lactate dehydrogenase (LDH)) and electrolytes (Na+, K+, and Cl−), were analysed. In addition, histological analysis was performed to assess cardiac and renal tissue damage. The concomitant administration of Bancha methylxanthines and doxorubicin showed a dose-dependent reduction in the serum biochemical parameters, indicating a decrease in the cardiac and renal tissue damage caused by the antibiotic. Histological analysis showed that pretreatment with methylxanthines at the dose of 5 mg/kg resulted in an almost normal myocardial structure and a significant decrease in the morphological kidney changes caused by doxorubicin exposure compared with the group that received doxorubicin alone. The putative mechanism is most likely related to a reduction in the oxidative stress caused by doxorubicin.