Miracle-dz/UniFAR-FTUs huggingface dataset:
Components of Unrealistic Optimism of College Students: The Case of the COVID-19 Pandemic

College students are among the most strongly affected populations by the coronavirus disease-2019 (COVID-19) pandemic because of uncertainty regarding academic success, future careers, and social life during their study period. Their mental health and behavior may dramatically be impacted. The study examined an unrealistic optimism of Israeli college students in assessing the health, security, and economic risks during the pandemic, and the contributions of these perceived risks to the prediction of psychological coping responses, such as well-being, and coping suppressing response of anxiety, expressed during this pandemic. Using social networks, a questionnaire was disseminated to students during the third lockdown that was implemented in Israel because of the pandemic. Depressive and anxiety symptoms, perceived threats, resilience, well-being, hope, and morale were measured using a structured quantitative questionnaire. First, we hypothesized that the three perceived risks would be inversely rated, so perceived health risk would be rated lowest, and perceived economic risk would be rated highest. The second and third hypotheses claimed that psychological coping responses articulated along this pandemic would be predicted by all these perceived risks, as well as the observance of pandemic precaution rules. The fourth hypothesis suggested that the three investigated perceived risks will positively and significantly correlate with each other. The results generally supported the hypotheses and indicated that the unrealistic optimism process was employed quite consistently by the participating students.
RIGI, TLR7, and TLR3 Genes Were Predicted to Have Immune Response Against Avian Influenza in Indigenous Ducks

Avian influenza is a disease with every possibility to evolve as a human-to-human pandemic arising out of frequent mutations and genetic reassortment or recombination of avian influenza (AI) virus. The greatest concern is that till date, no satisfactory medicine or vaccines are available, leading to massive culling of poultry birds, causing huge economic loss and ban on export of chicken products, which emphasizes the need to develop an alternative strategy for control of AI. In the current study, we attempt to explore the molecular mechanism of innate immune potential of ducks against avian influenza. In the present study, we have characterized immune response molecules such as duck TLR3, TLR7, and RIGI that are predicted to have potent antiviral activities against the identified strain of avian influenza through in silico studies (molecular docking) followed by experimental validation with differential mRNA expression analysis. Future exploitation may include immunomodulation with the recombinant protein, and transgenic or gene-edited chicken resistant to bird flu.
Modelled Economic Analysis for Dacomitinib–A Cost Effectiveness Analysis in Treating Patients With EGFR-Mutation-Positive Non-Small Cell Lung Cancer in China

Objectives To establish the cost-effectiveness of dacomitinib compared to gefitinib from the Chinese healthcare system perspective. Patients Advanced non-small cell lung cancer (NSCLC) harbouring epidermal growth factor receptor (EGFR) mutations. Methods Partitioned survival analysis was undertaken to examine the cost-effectiveness of dacomitinib utilising individual patient data (IPD) from the pivotal randomised controlled trial (RCT) (ARCHER 1050). The three health states modelled were progression-free, post-progression, and death. Parametric survival distributions were fitted to IPD against the Kaplan-Meier survival curves corresponding to progression-free survival (PFS) and overall survival (OS) outcomes by randomised groups. Costs included drug acquisition and administration, outpatient management (outpatient consultation and examinations), and best supportive care costs. Utility weights were sourced from the pivotal trial and other published literature. The incremental cost-effectiveness ratio (ICER) was calculated with costs and quality-adjusted life years (QALYs) discounted at an annual rate of 5%. Both deterministic and probabilistic sensitivity analyses were undertaken. Results In the base case, dacomitinib (CNY 265,512 and 1.95 QALY) was associated with higher costs and QALY gains compared to gefitinib (CNY 247,048 and 1.61 QALYs), resulting in an ICER of CNY 58,947/QALY. Using the empirical WTP/QALY threshold, dacomitinib is a cost-effective treatment strategy for patients with EGFR-mutation-positive advanced NSCLC. The probabilistic sensitivity analysis suggested that dacomitinib had a 97% probability of being cost-effective. Conclusions Dacomitinib is a cost-effective treatment strategy in treating patients with EGFR-mutation-positive NSCLC from the Chinese healthcare system perspective. The uncertainty around the cost-effectiveness of dacomitinib could be reduced if long-term survival data become available. Clinical Trial Registration NCT01024413
Public Emotional and Coping Responses to the COVID-19 Infodemic: A Review and Recommendations

Since its onset in early 2020, the coronavirus disease 2019 (COVID-19) pandemic has adversely affected not only the physical but also the mental health of people worldwide. Healthcare professionals and laypersons have sought to learn more about this novel and highly transmissible disease to better understand its etiology, treatment, and prevention. However, information overload and misinformation related to COVID-19 have elicited considerable public anxiety and created additional health threats. Collectively, these problems have been recognized by the World Health Organization as an “infodemic. ” This review provides an overview of the global challenges posed by the COVID-19 infodemic, and used the psychological entropy model as a guiding framework to explicate the potential causes of the infodemic and identify potential solutions to mitigate impacts on public health. We first examine the role of anxiety in information processing and then delineate the adverse impacts of the infodemic. Finally, we propose strategies to combat the infodemic at the public, community, and individual levels.
Knowledge Gaps in the Fetal to Neonatal Transition of Infants With a Congenital Diaphragmatic Hernia

Clinical research for infants born with a congenital diaphragmatic hernia (CDH) has until recently mainly focused on advances in prenatal and postnatal treatment. However, during the early perinatal transition period there are major physiological adaptations. For most infants these changes will happen uneventfully, but for CDH infants this marks the beginning of serious respiratory complications. In recent years, there is emerging evidence that the clinical management during the perinatal stabilization period in the delivery room may influence postnatal outcomes. Herein, we discuss major knowledge gaps and novel concepts that aim to optimize fetal to neonatal transition for infants with CDH. One such novel and interesting approach is performing resuscitation with an intact umbilical cord, the efficacy of this procedure is currently being investigated in several clinical trials. Furthermore, close evaluation of neonatal physiological parameters in the first 24 h of life might provide early clues concerning the severity of lung hypoplasia and the risk of adverse outcomes. We will provide an overview of trending concepts and discuss potential areas for future research.
Analyzing Enterprise Resource Planning System Implementation Success Factors in the Engineering–Construction Industry

Enterprise resource planning (ERP) systems offer many benefits to the engineering–construction industry. Many construction firms recognize the benefits of ERP system implementation; however, they still hesitate to adopt these systems due to high cost, uncertainties, and risks. This study identifies and analyzes critical factors that need to be considered to ensure successful ERP system implementation in the construction industry. First, this paper identifies the factors associated with the success and failure of ERP systems, and provides indicators to evaluate the success of such systems. Then, the paper develops an information system success model to analyze the relationships between factors and success indicators. Finally, the paper provides recommendations for successful ERP systems based on the analysis. The derived success factors should help senior managers in construction firms make better decisions and improve their business value by implementing the most effective EPR systems.
Therapeutic Potential of Vital Transcription Factors in Alzheimer’s and Parkinson’s Disease With Particular Emphasis on Transcription Factor EB Mediated Autophagy

Autophagy is an important cellular self-digestion and recycling pathway that helps in maintaining cellular homeostasis. Dysregulation at various steps of the autophagic and endolysosomal pathway has been reported in several neurodegenerative disorders such as Alzheimer’s disease (AD), Parkinson’s disease (PD), and Huntington disease (HD) and is cited as a critically important feature for central nervous system (CNS) proteostasis. Recently, another molecular target, namely transcription factor EB (TFEB) has been explored globally to treat neurodegenerative disorders. This TFEB, is a key regulator of autophagy and lysosomal biogenesis pathway. Multiple research studies suggested therapeutic potential by targeting TFEB to treat human diseases involving autophagy-lysosomal dysfunction, especially neurodegenerative disorders. A common observation involving all neurodegenerative disorders is their poor efficacy in clearing and recycle toxic aggregated proteins and damaged cellular organelles due to impairment in the autophagy pathway. This dysfunction in autophagy characterized by the accumulation of toxic protein aggregates leads to a progressive loss in structural integrity/functionality of neurons and may even result in neuronal death. In recent years TFEB, a key regulator of autophagy and lysosomal biogenesis, has received considerable attention. It has emerged as a potential therapeutic target in numerous neurodegenerative disorders like AD and PD. In various neurobiology studies involving animal models, TFEB has been found to ameliorate neurotoxicity and rescue neurodegeneration. Since TFEB is a master transcriptional regulator of autophagy and lysosomal biogenesis pathway and plays a crucial role in defining autophagy activation. Studies have been done to understand the mechanisms for TFEB dysfunction, which may yield insights into how TFEB might be targeted and used for the therapeutic strategy to develop a treatment process with extensive application to neurodegenerative disorders. In this review, we explore the role of different transcription factor-based targeted therapy by some natural compounds for AD and PD with special emphasis on TFEB.
Diagnosis and Stratification of Pseudomonas aeruginosa Infected Patients by Immunochemical Quantitative Determination of Pyocyanin From Clinical Bacterial Isolates

The development of a highly sensitive, specific, and reliable immunochemical assay to detect pyocyanin (PYO), one of the most important virulence factors (VFs) of Pseudomonas aeruginosa, is here reported. The assay uses a high-affinity monoclonal antibody (mAb; C.9.1.9.1.1.2.2.) raised against 1-hydroxyphenazine (1-OHphz) hapten derivatives (PC1; a 1:1 mixture of 9-hydroxy- and 6-hydroxy-phenazine-2-carobxylic acids). Selective screening using PYO and 1-OHphz on several cloning cycles allowed the selection of a clone able to detect PYO at low concentration levels. The microplate-based ELISA developed is able to achieve a limit of detection (LoD) of 0.07 nM, which is much lower than the concentrations reported to be found in clinical samples (130 μM in sputa and 2.8 μM in ear secretions). The ELISA has allowed the investigation of the release kinetics of PYO and 1-OHphz (the main metabolite of PYO) of clinical isolates obtained from P. aeruginosa-infected patients and cultured in Mueller–Hinton medium. Significant differences have been found between clinical isolates obtained from patients with an acute or a chronic infection (~6,000 nM vs. ~8 nM of PYO content, respectively) corroborated by the analysis of PYO/1-OHphz levels released by 37 clinical isolates obtained from infected patients at different stages. In all cases, the levels of 1-OHphz were much lower than those of PYO (at the highest levels 6,000 nM vs. 300 nM for PYO vs. 1-OHphz, respectively). The results found point to a real potential of PYO as a biomarker of P. aeruginosa infection and the possibility to use such VF also as a biomarker for patient stratification[2] and for an effective management of these kinds of infections.
Cariprazine in the Treatment of Bipolar Disorder: Within and Beyond Clinical Trials

Bipolar disorder (BD) is chronic psychiatric disorder associated with significant impairment in psychosocial functioning and quality of life. Although current pharmacological treatments for BD have improved its clinical management, many patients do not achieve remission, particularly those suffering from bipolar depression. In addition, available treatments are associated with a myriad of potential adverse effects, which highlights the need for novel therapeutic agents that can be effective for both phases of the illness with a reduced side effect burden. Cariprazine is a novel antipsychotic that is a dopamine D2/D3 partial agonist with a preference for D3 receptors. In this review, we examine the pharmacological properties, clinical efficacy and tolerability profile of cariprazine in patients with BD, taking into account the latest clinical trials data. We also review post hoc analyses addressing clinically relevant subgroups and symptom domains in BD. Current evidence suggests efficacy for cariprazine 3–12 mg/day in the treatment of acute manic and mixed episodes; for bipolar depression, the efficacy of cariprazine appears to be dose-related, with doses of 1.5–3 mg/day beneficial as monotherapy. Cariprazine is overall well-tolerated by patients in both manic and depressive episodes. Its most common side effects relative to placebo include akathisia, extrapyramidal symptoms and nausea. There are no metabolic concerns reported with cariprazine use. In summary, the latest evidence suggests that cariprazine is an effective and safe treatment option for BD.
Identification of Candidate Genes Associated With Hypoxia Tolerance in Trachinotus blochii Using Bulked Segregant Analysis and RNA-Seq

Golden Pompano (Trachinotus blochii) has rapidly developed into the one of the main valuable fish species in Chinese marine aquaculture. Due to its rapid growth, active metabolism, and high oxygen consumption, hypoxia will increase its mortality and cause serious economic losses. We constructed two experimental groups of fish with different degrees of tolerance to hypoxia, used BSR-Seq analysis based on genome and genetic linkage groups to locate SNPs and genes that were related to the differences in hypoxia tolerance. The results showed that hypoxia tolerance SNPs of golden pompano may be jointly determined by multiple linkage groups, especially linkage groups 18 and 22. There were 768 and 348 candidate genes located in the candidate regions of the brain and liver, respectively. These genes were mainly involved in anaerobic energy metabolism, stress response, immune response, waste discharge, and cell death. The prostaglandin-endoperoxide synthase 2 (PTGS2) on LG8, which is involved in the metabolism of arachidonic acid, has a G/A nonsynonymous mutation at position 20641628, and the encoded amino acid was changed from hydrophobic aspartic acid to asparaginate. The specific pathway of the RIG-I-like receptor signaling pathway in the liver may mediate the metabolic system and the immune system, linking glucose metabolism with immune regulation. The death of the hypoxia-intolerant group may be due to the accumulation of lactic acid caused by the activation of anaerobic glycolysis during the early stage of hypoxia stress, and the activation of type I interferon was inhibited, which resulted in decreased immunity. Among the genes involved in the RIG-I-like receptor signaling pathway, the CYLD Lysine 63 Deubiquitinase (CYLD) located on LG16 had a G/T nonsynonymous mutation at position 13629651, and the encoded amino acid was changed from alanine acid to valine. The interferon induced with helicase C domain 1 (Ifih1) located on LG18 has a G/C nonsynonymous mutation at position 16153700, and the encoded hydrophilic glycine was changed to hydrophobic alanine. Our findings suggest these SNPs may assist in the molecular breeding of hypoxia-tolerant golden pompano, and speculate that the balance of glucose and lipid metabolism plays a key role in Trachinotus blochii under acute hypoxia.
Heuristics-guided evolutionary approach to multiobjective generation scheduling

A novel approach for multiobjective generation scheduling is presented. The work reported employs a simple heuristics-guided evolutionary algorithm to generate solutions to this nonlinear constrained optimisation problem where the objectives are mutually conflicting and equally important. The algorithm produces a cost-emission frontier of pareto-optimal solutions, any of which can be selected based on the relative preference of the objectives. Within this framework, an efficient search algorithm has been developed to deal with the combinatorial explosion of the search space such that only feasible schedules are generated based on heuristics. This approach has been evaluated by successful experiments with three test systems containing 11, 19 and 40 generating units. Attaching importance to heuristics results in producing high quality solutions in a reasonable time for this large scale tightly constrained problem.
Variation in the origin of suprascapular artery

Variation in the origin of the suprascapular artery was observed in one of the 30 cadavers dissected. The suprascapular artery in our case emerged from the first part of the axillary artery on the left side in a male cadaver, while it arose from the thyrocervical trunk on the right side in the same cadaver. Later in its course it passed obliquely behind the clavicle and brachial plexus to reach the suprascapular notch where it was accompanied by the suprascapular nerve, and both together passed beneath the transverse scapular ligament. It then supplied supraspinatus and took part in the anastomosis around the scapula. © IJAV. 2010; 3: 178–179.
Intersectional and Entangled Risks: An Empirical Analysis of Disasters and Landfills

Landfills are environmental hazards linked to harms, such as the production of greenhouse gases and the accumulation of toxins in natural and human systems. Although environmental justice research has established such unwanted land uses as hazardous waste sites occur in poor communities and communities of color, less is known about the relationship between landfills and gender. As a driver of global climate change, there is also limited research into the relationships among disasters, landfills, and climate-related risks. To fill this gap, the current study uses an intersectional approach to theorize and empirically analyze relationships among landfills, disasters, race, class, and gender. We employ negative binomial regression to analyze a unique U.S. dataset of landfill counts, total number of disasters, and socio-demographic characteristics, including the use of two-way interactions among race, sex, and socioeconomic status variables, and number of federally-declared disasters that influence landfill counts. Findings suggest that intersecting axes of social location (specifically gender and race) are not multiplicative when it comes to landfills or the environmental risks they pose, but we argue may be entangled—that is related in non-linear and complicated ways. Using intersectionality theory, we interpret the findings to indicate that women of color are agents of resistance enacting their own forms of power against dominant structural arrangements that produce and maintain environmental injustices. Conclusions and implications for environmental justice, intersectionality, and climate risks are further discussed.
Molecular Evolution of Severe Acute Respiratory Syndrome Coronavirus 2: Hazardous and More Hazardous Strains Behind the Coronavirus Disease 2019 Pandemic and Their Targeting by Drugs and Vaccines

Within almost the last 2 years, the world has been shaken by the coronavirus disease 2019 (COVID-19) pandemic, which has affected the lives of all people. With nearly 4.92 million deaths by October 19, 2021, and serious health damages in millions of people, COVID-19 has been the most serious global challenge after the Second World War. Besides lost lives and long-term health problems, devastating impact on economics, education, and culture will probably leave a lasting impression on the future. Therefore, the actual extent of losses will become obvious only after years. Moreover, despite the availability of different vaccines and vaccination programs, it is still impossible to forecast what the next steps of the virus are or how near we are to the end of the pandemic. In this article, the route of molecular evolution of the coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is thoroughly compiled, highlighting the changes that the virus has undergone during the last 2 years and discussing the approaches that the medical community has undertaken in the fight against virus-induced damages.
Optimal modal beamforming of bandpass signals using an undersized sparse vertical hydrophone array: theory and a shallow-water experiment

Conventional methods for modal beamforming of underwater acoustic signals using a vertical-line hydrophone array (VLA) can suffer significant degradation in resolution when the array is geometrically deficient, i.e., consists of sparsely spaced elements and spans the water column partially or is poorly navigated. Designed for estimating the coefficients of the normal modes, these conventional methods include the direct projection (DP) of the data on the calculated mode shapes and least-squares (LS) fitting of the mode sum to the data. The degradation, in the form of modal cross talk or sidelobes, is a result of an undersampling in depth. This cross talk may be mitigated with the application of proper space-time filter constraints in the case of a pulse transmission. In this paper, a generalized least-squares (GLS) mode beamformer, capable of incorporating physical space-time constraints on the propagation of sound, is presented. The formulation is based on the well-known theorem of Gauss and Markov. Initialized by a model prediction of the basic arrival structure of the normal modes and incorporating, iteratively, refined estimates of the statistics of the modal fluctuations, this GLS technique strives to boost the resolution of a geometrically deficient VLA. The improvement is demonstrated using the VLA data collected during a shallow-water tomography experiment in the Barents Sea. The superiority of the GLS method over the conventional DP and LS methods is evident, providing a high-quality time series of modal arrivals as a function of geophysical time, which, in turn, reveals the dominant time scales of the oceanic processes associated with the Barents Sea Polar Front.