Miracle-dz/UniFAR-FTUs huggingface dataset:
Identification of the key miRNAs and target genes in basal cell carcinoma by bioinformatics analysis

: The highly tissue-destructive and localized accumulation of basal cell carcinoma(BCC) makes it one of the most important cancers affecting people's lives. Existing therapeutic approaches, including surgical treatment, chemotherapy, and Hedgehog pathway inhibitors, have failed to achieve broad therapeutic effects for various reasons. This study aims to explore additional potential therapeutic targets and possible diagnostic and prognostic biomarkers using bioinformatics analysis. The Gene Expression Omnibus (GEO) database identified the microarray dataset GSE34535. The GEO2R tool was used to screen out differentially expressed genes (DEGs) between BCC and non-lesional skin. Potential target genes of DE-miRNA were screened using the miRWalk, mirDIP and miRTarBase databases. Gene Ontology function and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis for target genes were established using the DAVID database. Protein–protein interaction network and miRNA-hub gene network were analyzed based on the STRING database and visualized by Cytoscape software. 51 up-regulated DE-miRNAs and 38 down-regulated DE-miRNAs were identified from the BCC samples. miR-455-5p was mainly up-regulated and miR-139-5p was mainly down-regulated. Two key bub genes MAPK1 and EGFR were identified in the PPI network. Four out of the ten hub genes were regulated by up-regulated miR-18a and four by down-regulated miR-133b. Viral infections were also identified in the study. Bioinformatics identified four miRNAs and two important hub genes that may be associated with BCC, and it was suggested that viruses may play a role in BCC. Cytoscape determine
Monolithic 9 GHz passively mode locked quantum dot lasers directly grown on on-axis (001) Si

Optical frequency comb direct generation on silicon by mode locked lasers (MLLs) is promising as it offers high wavelength channel counts and ultrashort pulses that will benefit future large-scale high capacity silicon photonic integrated circuits. Here, we demonstrate two-section quantum dot (QD) MLLs that are directly grown on a complementary metal–oxide–semiconductor compatible on-axis (001) silicon substrate by employing molecular beam epitaxy. The lasers, incorporating five layers of InAs QDs, operate in the O-band wavelength range with a pulse repetition rate around 9 GHz. A pulsewidth reduction of 48% of the narrowest achievable pulse from each QD MLL is obtained when the saturable absorber (SA) section length ratio is increased from 8% to 23%. The device with the longest SA section exhibits a more than 50 dB fundamental RF peak signal to noise floor ratio with 1.3 ps pulses.Optical frequency comb direct generation on silicon by mode locked lasers (MLLs) is promising as it offers high wavelength channel counts and ultrashort pulses that will benefit future large-scale high capacity silicon photonic integrated circuits. Here, we demonstrate two-section quantum dot (QD) MLLs that are directly grown on a complementary metal–oxide–semiconductor compatible on-axis (001) silicon substrate by employing molecular beam epitaxy. The lasers, incorporating five layers of InAs QDs, operate in the O-band wavelength range with a pulse repetition rate around 9 GHz. A pulsewidth reduction of 48% of the narrowest achievable pulse from each QD MLL is obtained when the saturable absorber (SA) section length ratio is increased from 8% to 23%. The device with the longest SA section exhibits a more than 50 dB fundamental RF peak signal to noise floor ratio with 1.3 ps pulses.
Pathological manifestations and immune responses of serotypes Ia and III Streptococcus agalactiae infections in Nile tilapia ( Oreochromis niloticus )

Streptococcus agalactiae (Group B Streptococcus, GBS) infections cause serious worldwide damage to fish farming. Here, we evaluated the pathological manifestations and immune responses of Nile tilapia (Oreochromis niloticus) infected with GBS serotype Ia (GBS-Ia) and GBS serotypes III (GBS-III). Experimental infection of fish with GBS by intraperitoneal injection indicated the severity of GBS-Ia infection as shown by the LD50 of GBS-Ia and GBS-III, being 1.5810 6 CFU/fish and 2.1010 CFU/fish, respectively. The onset of disease and clinical observation revealed notable differences between the GBS-Ia and GBS-III infections. Histological findings showed severe changes of the liver, pancreas, kidney and brain of fish infected with GBS. In addition, significantly different haemato-immunological parameters were observed between GBS-Ia and GBS-III infected fish. Differences in the pathological manifestations and immune responses of GBS-Ia and GBS-III infections in tilapia are of practical use for fish pathologists who monitor tilapia mortality resulting from GBS infections.
The Efficacy of Selective Credit Policies: An Alternative Test: A Note

In a recent article in this journal Kane [4] presents a case against selective credit allocation. His argument is based on the social costs involved in implementing and enforcing such policies and on econometric evidence that suggests that the effects of credit controls on expenditure flows are, at best, short-lived. Kane's theoretical discussion stresses the ability of lenders and borrowers ' 'to relabel debt contracts and to substitute other less efficient unregulated (even specifically devised) forms of credit for regulated ones " [4, p. 67]. The econometric evidence that he cites focuses primarily on the role of selective credit policies in influencing investment in housing, the area where most policy initiatives have been taken. However, there have also been some studies of the usefulness of credit allocation programs in affecting expenditures on consumer durable goods, and some of this evidence does not appear to support Kane's position. The latter studies are frequently based on correlations between particular expenditure flows and the flows of credit typically used to finance those expenditures. The strong positive associations that are observed between these variables have been interpreted as evidence that selective credit policies can alter expenditure patterns [2, 7]. The problem with these analyses is that such correlations may also reflect the influence of expenditures on customary credit flows or the simultaneous response of both variables to other factors. An alternative test that is far less susceptible to this reverse or simultaneous causation interpretation follows quite naturally from a simple extension of a model of consumer durable goods expenditures developed by Mishkin [6]. The first section of this note provides a brief discussion of the Mishkin model and our proposed modification. In the second section the extended model is subjected to empirical test. The third and concluding section summarizes the results and compares them to earlier studies, including our own [3].
Comparative Analysis of Urban Heat Island Intensities in Chinese, Russian, and DPRK Regions across the Transnational Urban Agglomeration of the Tumen River in Northeast Asia

Quantification of the spatial pattern of urban heat island intensities across the transnational urban agglomeration of the Tumen River is important for the promotion of sustainable regional development. This study employed Landsat images and MODIS LST data obtained in 2016 to determine the intensity of urban heat islands in this region, enabling direct comparison of data from the sub-regions of China, Democratic People’s Republic of Korea (DPRK), and Russia. The average urban heat island intensity for the region was found to be 1.0 °C, with the highest intensity of 3.0 °C occurring during the summer time. The intensity of urban heat islands on the Chinese side was higher than on the other two sides, with city size, socio-economic development levels and vegetation coverage significantly affect their intensity. Urban heat island effects in Chinese cities in the region contribute increases in maximum summer temperatures and the number of high-temperature days that pose a threat to the health of their residents. The factors that influence urban heat island intensities in these cities and the impacts of urban heat island effects on the quality of life and health of residents are discussed. Therefore, it is desirable to reduce the impact of urban heat island effects on cities in the region by increasing the area of green spaces they contain, as well as controlling their size and population.
High precision U/Th dating of the rock paintings at Mt. Huashan, Guangxi, southern China

Abstract The rock art and the associated natural scenery at 38 sites located in the Zuojiang River valley, in the southwest of Guangxi Zhuang Autonomous Region, southern China, were inscribed recently on UNESCO’s World Heritage List. The painted panel at the site of Mt. Huashan is probably the largest known rock art panel in the world, consisting of approximately 1900 identifiable figures and occupying an area of approximately 8000 m2. To determine a precise age on the rock art at Mt. Huashan, 56 secondary carbonate layers above and below the paintings were studied for their mineralogy, oxygen, and carbon isotopic compositions and dated by the 230Th/U method. The 230Th/U dating results demonstrate that ages of the rock paintings can be bracketed between 1856±16 and 1728±41yr BP corresponding to the middle to the end of the Eastern Han dynasty (AD 25 to 220). The results imply that the rock painting practices at Mt. Huashan probably lasted more than a century, and the Zuojiang rock art is younger than that at Baiyunwan and Cangyuan in Yunnan Province by 1 to 10 centuries.
Ionospheric response to wave‐accelerated electrons at the poleward auroral boundary

[1] The local ionospheric response to an auroral intensification at the poleward auroral boundary has been investigated using the incoherent scatter radar (ISR) and optical instrumentation at Sondrestrom, Greenland, in conjunction with space-bome measurements by the IMAGE and FAST satellites. ISR elevation scans through the illuminated region revealed filamentary columns of enhanced plasma density, ∼5 km in latitude by ∼200 km in altitude. Column densities were typically 5 × 10 11 /m 3 above background and often constant over a broad range of altitudes. The brightness of the O + 732-733 nm multiplet, monitored simultaneously by a near-infrared spectrometer, exceeded 1.2 kR during one 4-min period (a factor of ∼4 brighter than previously reported auroral measurements). A time-dependent model was developed to relate O + emission intensities to O + column densities for a given illumination time. The results suggested that the electron source was composed of kilometer-scale flux tubes locked in the E x B flow for several minutes whose average energy varied temporally between 1 keV over their illumination lifetime. Conjugate electrons measured by the FAST satellite at 1700 km showed evidence for energization by inertial Alfven waves. Ionization rates computed from these spectra were sufficient to account for the observed filamentary ionospheric structure. The implications of such ionization patterns for electrodynamic coupling with the magnetosphere are discussed.
17- and 24-GHz observations of southern pulsars

We present observations of PSRs J0437-4715, J0738-4042, J0835-4510,J0908-4913, J1048-5832, J1622-4950, J1644-4559, J1721-3532 andJ1740-3015 at 17 GHz using the Parkes radio telescope. All nine weredetected at 17 GHz, additionally, we detected PSR J0835-4510 andJ1622-4950 at 24 GHz. Polarization profiles of each pulsar and thevariation with frequency are discussed. In general, we find that thehighly polarized edge components of young pulsars continue to dominatetheir profiles at 17 GHz. Older pulsars ({\gsim}10$^{5}$ yr) appearto be almost completely depolarized. Our detection of PSR J0437-4715 isthe highest frequency observation of a millisecond pulsar to date, andimplies a luminosity at 17 GHz of 14 {$\mu$}Jy kpc$^{2}$, and a meanspectral index of 2.2. We find that the spectral index of the magnetar PSR J1622-4950 is flatbetween 1.4 and 24 GHz, similar to the other known radio magnetars XTEJ1810-197 and 1E 1547.0-5408. The profile is similar to that at 3.1 GHz,and is highly linearly polarized. Analysis of the frequency evolution ofthe profile of PSR J0835-4510 show that the profile is made of fourcomponents that vary with frequency only in their amplitude. The widthand separation of the components remain fixed and the spectral index ofeach component can be determined independently.
Practical Applications of Protease Enzymes in Paper Conservation

Paper conservators have long recognized the benefits of enzymes in the conservation treatment of works of art. Most commonly, hydrolase-type enzymes are employed in the conservation of works on paper to assist in the breakdown of adhesive residues from previous restorations or to facilitate the removal of secondary supports such as linings or mounts. The principal advantages of these enzymes are their specificity and efficiency in catalyzing hydrolytic cleavage of polymers such as proteins, polysaccharides, and lipids. The author evaluates the effectiveness of two protease enzymes while taking into consideration cost effectiveness, optimal working conditions, and aftertreatment effects. The fruition of this research was realized in the successful conservation treatment of an Indian miniature utilizing the protease enzyme trypsin incorporated into an agarose gel. The conservation treatment of this item is discussed in detail.
Case Series of Pneumomediastinum in COVID-19 Infection

Introduction: Pneumomediastinum is rare in viral infection of the lung however in COVID-19 patients it is more common. Study Design: Case series of 14 moderate to severe COVID cases complicated by Pneumomediastinum admitted to Saint George Hospital over 4 months. Data was collected retrospectively from medical charts of the patients. Results: Most of the patients were males. Average hospital stay was 15.21 days. Five patients (35.72%) developed pneumomediastinum without any kind of mechanical ventilation during hospitalization. Around 35.72% of the patients were discharged and the average time till death was 8.8 days. Conclusion: Pneumomediastinum can develop without any positive pressure ventilation in COVID-19 infection.
Aspirin-induced long non-coding RNA suppresses colon cancer growth

Background To study the effect of long non-coding RNAs (lncRNA) on aspirin-treated colon cancer cells. Methods To study the changes of lncRNA in aspirin-treated colon cells by microarray analysis, real-time quantitative PCR (qPCR) was used to verify the expression of selected lncRNA and mRNA. The effects of aspirin on the proliferation and metastasis of the siRNA transfected cells and control colon cancer cells were detected by Cell Counting Kit-8 (CCK-8) and Transwell experiments. Bioinformatics tools were employed to analyze the potential function of lncRNA. Results Compared with the control group, aspirin inhibited the proliferation and metastasis of colon cancer cells. Microarray analysis showed that a total of 10,568 lncRNAs and 22,126 mRNAs were noticeably expressed in the aspirin-treated group (≥1.5-fold, P<0.05). The qPCR results showed that lncRNA and mRNA expressions were consistent with microarray analysis. The analysis of the co-expression network profiles of 58 lncRNA and 101 mRNA differential genes showed a total of 158 nodes and 791 connections. Analysis of Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways revealed that a variety of lncRNAs (NEAT1, LOC152578) were involved in the inhibition mechanism of aspirin in colon cancer. Conclusions lncRNA NEAT1 and LOC152578 are involved in the inhibition of tumor cell growth and metastasis by aspirin. The results of these analyses will help us further understand the mechanism of action of aspirin and the roles of lncRNAs in the prevention and treatment of colon cancer.
A survey on dental treatments provided under general anesthesia for pediatric patients: A hospital-based retrospective audit

Aim: To evaluate the dental procedures carried out under general anesthesia (GA) on children with primary dentition in a pediatric hospital. Methods: The study comprised all children with primary dentition treated under GA at a private pediatric hospital from January 2014 to December 2017. The data was tabulated based on the dental records include reasons for dental treatment under general anesthesia (DGA), dental status, and treatment provided. Descriptive statistics were used for statistical analysis and chi-square test used for the comparison. Results: Forty-eight children with primary dentition were utilized the service of general anesthesia for dental treatment. Dental caries (78%) was the most common reason for DGA (p 0.05). Overall restorative procedures (60%), extractions (26%), and preventive procedures (14%) were performed under GA (p<0.05). Among, restorative procedures stainless steel crowns (54.2%) were given more priority than other restorative materials. Conclusions: Dental caries was found to be a common reason for DGA. Restorative procedures were given priority over surgical and preventive procedures. Stainless steel crowns were extensively used compared to other materials.
A model for designing a procurement-inventory system as a defence against a recurring epidemic

The COVID-19 pandemic has caused a general shortage of personal protection products and therapeutic devices, which has highlighted the need for each country to have its own production resources and not depend solely on imports. Given the time that elapses between the onset of an epidemic and its detection, as well as the time required to activate production and the lead time of purchasing operations, it is necessary to have a permanent reserve, which we call shield stock, in order to immediately meet the demand for equipment at the beginning and throughout the course of the epidemic. This situation is analysed in order to identify the most relevant decisions in the scenario described, formulate a cost optimisation model and develop procedures to find the most economical combination of shield stock, domestic production capacity and imports to guarantee the immediate satisfaction of demand and the restoration of the shield stock after the epidemic, as a preventative measure. The procedure is illustrated with a specific pattern of the spread of the epidemic and some numerical examples.
Geophysical study of palaeo-incisions in the Šventoji-Būtingė coastal ar ea, north-west Lithuania

Palaeo-incisions (palaeo-tunnels, tunnel valleys, buried valleys, etc.) comprise the most prominent features in the sub-Quaternary surface covered by the Scandinavian continental ice sheets. An exception is the Scandinavian crystalline bedrock region. Palaeo-incisions are objects of Quaternary geology both from scientific and practical point of view and have been previously mapped along the Lithuanian coastal area using gravimetric and transient electromagnetic methods, complemented by traditional drilling. This paper presents an approach for high-resolution identification of the palaeo-incisions in the Sventoji-Būtingė coastal area of north-western Lithuania. Several geophysical methods have been tested, including shallow seismic reflection profiling, electrical tomography and ground-penetrating radar. A combination of shallow seismic reflection and electrical tomography profiling provides an optimal survey strategy for high-resolution investigations of
Precarity, Hospitality, and the Becoming of a Subject That Matters: A Study of Syrian Refugees in Lebanese Tented Settlements

How is it possible to gain a sense that you have a voice and that your life matters when you have lost everything and live your life as a ‘displaced person’ in extreme precarity? We explore this question by examining the mundane everyday organizing practices of Syrian refugees living in tented settlements in Lebanon. Contrasting traditional empirical settings within organization studies where an already placed and mattering subject can be assumed, our context provides an opportunity to reveal how relations of recognition and mattering become constituted, and how subjects in precarious settings become enacted as such. Specifically, drawing on theories on the relational enactment of self and other, we show how material-discursive boundary-making and invitational practices – organizing a home, cooking and eating, and organizing a digital ‘home’ – function to enact relational host/guest subject positions. We also disclose how these guest/host relationalities create the conditions of possibility for the enactment of a subject that matters, and for the despair enacted in everyday precarious life to transform into ‘undefeated despair’.
Spatial Heterogeneity of Uplift Pattern in the Western European Alps Revealed by InSAR Time‐Series Analysis

The Western European Alps display measurable surface deformation rates from leveling and GNSS data. Based on the time‐series analysis of 4 years of Sentinel‐1 data, we propose for the first time an InSAR‐based mapping of the uplift pattern affecting the Western Alps on a ∼350 × 175‐km‐wide area. This approach provides a denser spatial distribution of vertical motion despite the high noise level inherent to mountainous areas and the low expected deformation signal. Our results show consistency with other geodetic measurements at the regional scale, and reveal smaller‐scale spatial variations in the uplift pattern. Higher uplift rates are found within the external crystalline massifs compared to surrounding areas, in agreement with the variations expected from recent deglaciation and long‐term exhumation data. This work brings the first InSAR‐based geodetic clue of differential uplift within the Alpine belt in response to the surface and deep processes affecting the belt.
Cytological Analysis of Pleural and Peritoneal Fluids : A Two Year Study in Tertiary Health Care Centre

DOI: 10.21276/sjm.2018. 3.4. 5 Abstract: Cytological examination of cavity effusions is extremely important as it highlight the cause, presence of metastatic cells, typing of unknown cases, prognosis and staging of cancer. To study and evaluate trends in cytological evaluation of cavity effusions for various pathological conditions in a tertiary health care centre. 2) To correlate their frequency in relation to diagnosis. Our Study was cross-sectional study performed in Department of Pathology, Sri Aurobindo Medical College and Post Graduate Institute from 1st January 2013 to 31st December 2014. Serous cavity effusions included in the study were pleural and peritoneal in origin. All other fluids (pericardial and synovial fluid) were excluded from the study. The history and relevant parameters were noted and correlated clinically. Cytospin and Conventional smear methods were performed on pleural and peritoneal fluids. Both air dried and wet fixed smears in methyl alcohol were used and stained with Papanicolaou (PAP) and MayGrunwald-Giemsa (MGG) stain. Out of 885 cases, 400 (45.19%) were pleural fluid, 485(54.8%) were peritoneal fluid . 806 (91%) were of benign effusion and 79 (8.92%) were of malignant effusion. Total transudate cases in our study were 611 (69%) and exudates were 274 (30.9%). Male to female ratio was 1.5:1 with youngest patient 20 years old and eldest was 85years old. In younger age group benign effusions are common and malignant in older age group. Morphology and staining with MayGrunwald-Giemsa (MGG) and Papanicolaou (PAP) helped in better interpretation. Preliminary fluid analysis for cytology in resource limited settings, still remains the most convenient and cost effective method in arriving at the diagnosis, thereby reducing the need for invasive investigations and their related complications. Presence and absence of malignant cells at times can be the only clue to the presence of malignancy thereby affecting the prognosis and treatment outcome of the patient.