Miracle-dz/UniFAR-FTUs huggingface dataset:
Correlation between Serum Vitamin D3 Levels and Severity of COVID-19, Experience from a COVID-19-Dedicated Tertiary Care Hospital from Western India

Context: It is postulated that 25(OH)D deficiency is associated with a worse prognosis of COVID-19. Aims: We aimed to find out whether baseline serum 25-hydroxy vitamin D levels were correlated with COVID-19 disease severity or not in Indian population. Settings and Design: It is a prospective observational study. Methods and Material: We prospectively recruited 200 COVID-19-positive adult patients and measured their baseline vitamin D levels on admission and prospectively followed their clinical course for their outcome and correlated the association. Statistical Analysis Used: The continuous data were represented as mean (±SD) or median (IQR), while the categorical data were represented as proportions. Parametric data were analysed using unpaired T-test and ANOVA for two and more than two groups, and for categorical, nonparametric data, Chi-square test were applied. A two-sided P value of <0.05 was considered as statistically significant with 95% confidence interval. Results: Eighty-six per cent (172/200) of patients had hypovitaminosis D (<30 ng/mL). The prevalence of 25(OH) severe deficiency, deficiency and vitamin D insufficiency was 23%, 41% and 22%, respectively. Clinical severity was graded as asymptomatic (11%), mild (14%), moderate (14.5%), severe (37.5%) and critical (22%). Sixty per cent of patients had clinically severe or critical disease requiring oxygen support with eleven per cent (n = 22) mortality overall. Age (P: 0.001), HTN (P: 0.049) and DM (P: 0.018) were negatively associated with clinical severity. No linear association was found between vitamin D levels and clinical severity. Low vitamin D levels had a significant inverse association with inflammatory markers like neutrophil–lymphocyte ratio (NLR, P: 0.012) and IL-6 (P: 0.002). Conclusions: Vitamin D deficiency was not associated with worse outcomes of COVID-19 infection in Indian population.
Generalised 2D ballooning theory in tokamaks : obtaining the global properties of linear microinstabilities from the local ballooning equations

This thesis involves the development of a technique to improve our understanding of the impact of global effects on linear microinstabilities. The technique combines local ballooning solutions with higher order theory to reconstruct the global eigenmode structure and associated global eigenvalue. In this work, the theory of 2D ballooning eigenmodes has been extended beyond the two limits of highly unstable isolated modes, which often sit on the outboard mid-plane, and less unstable general modes that peak on the top or bottom of the tokamak. Our generalised solutions can account for global modes with arbitrary poloidal positions which, in turn, enables us to explore experimentally relevant regimes with arbitrary equilibria. Furthermore, using a generally applicable gyrokinetic plasma model, the global mode structures of the ion temperature gradient (ITG) driven microinstability have been reconstructed directly from the local gyrokinetic code, GS2. Using CYCLONE base case parameters with the circular Miller equilibrium model we benchmark our calculation against direct global gyrokinetic simulations. Introducing a radially varying profile for the mode drive that peaks about a reference rational surface $x_{s}=0$, while holding other profiles constant, leads to a highly unstable isolated mode. The effect of the other equilibrium profiles is found to be stabilising. However, rotational flow shear introduced via a Doppler shift in the real local frequency, i.e $\omega_{0} \rightarrow \omega_{0} + n\qprime\gamma_{E} x_{s}$, where $n$ is the toroidal mode number and $\gamma_{E}$ represents the strength of the flow shear, can cancel the influence of the other profile variations and, for a critical value of flow shear, a highly unstable isolated mode can be captured again. Finally, for an equilibrium that exhibits an isolated mode, we have also investigated the effect of the flux surface shaping through elongation $\bar{\kappa}$ and triangularity $\bar{\delta}$. Our simulations indicate that, depending on the value of $\bar{\kappa}$ and $\bar{\delta}$, the effect of shaping can be both stabilising and destabilising.
RASA3 is a candidate gene in sickle cell disease‐associated pulmonary hypertension and pulmonary arterial hypertension

Abstract Pulmonary hypertension (PH) is associated with significant morbidity and mortality. RASA3 is a GTPase activating protein integral to angiogenesis and endothelial barrier function. In this study, we explore the association of RASA3 genetic variation with PH risk in patients with sickle cell disease (SCD)‐associated PH and pulmonary arterial hypertension (PAH). Cis‐expression quantitative trait loci (eQTL) were queried for RASA3 using whole genome genotype arrays and gene expression profiles derived from peripheral blood mononuclear cells (PBMC) of three SCD cohorts. Genome‐wide single nucleotide polymorphisms (SNPs) near or in the RASA3 gene that may associate with lung RASA3 expression were identified, reduced to 9 tagging SNPs for RASA3 and associated with markers of PH. Associations between the top RASA3 SNP and PAH severity were corroborated using data from the PAH Biobank and analyzed based on European or African ancestry (EA, AA). We found that PBMC RASA3 expression was lower in patients with SCD‐associated PH as defined by echocardiography and right heart catheterization and was associated with higher mortality. One eQTL for RASA3 (rs9525228) was identified, with the risk allele correlating with PH risk, higher tricuspid regurgitant jet velocity and higher pulmonary vascular resistance in patients with SCD‐associated PH. rs9525228 associated with markers of precapillary PH and decreased survival in individuals of EA but not AA. In conclusion, RASA3 is a novel candidate gene in SCD‐associated PH and PAH, with RASA3 expression appearing to be protective. Further studies are ongoing to delineate the role of RASA3 in PH.
Influence of Surface Structure on Ball Properties during a Professional Water Polo Game

The use of modern materials in sports, in terms of chemical composition and surface texture, entails both progress in results and an increasing discrepancy in the technical parameters of the equipment used. This paper aims to demonstrate the differences between balls admitted to a league and world championships in composition, surface texture, and the influence of these parameters on the water polo game. This research compared two new balls produced by top companies producing sports accessories (Kap 7 and Mikasa). To obtain the goal, the measurement of the contact angle, analysis of the material using Fourier-transform infrared spectroscopy, and optical microscopic evaluation were used. The analysis of the surface free energy shows significant differences (Kap 7 32.16 mJ/m2, Mikasa 36.48 mJ/m2). In the case of both balls, anisotropies of the structure of the furrows were observed, however, the Mikasa ball is slightly more homogeneous than the Kap 7 ball. The obtained results from the analysis of the contact angle, as well as the composition and real feedback from the players, indicated the need to standardize the material aspect of the regulations so that the sports results are repeatable every time.
The Archaeology and History of Rock-cut Cisterns and Open Water Reservoirs in the Negev Highlands

This article provides the final assessment of a large-scale optically stimulated luminescence (OSL) dating project of water installations in the arid Negev Highlands, southern Israel. Results from five open reservoirs and five rock-cut cisterns are reported. By sampling spoil piles, feeding channels, and accumulation of sediments within reservoirs and cisterns, their construction and phases of maintenance and abandonment are dated. Conventional wisdom argued for progress from simpler open reservoirs in the Bronze or Iron Ages to the more sophisticated rock-cut cisterns of the Nabatean–Byzantine periods. It is shown that open reservoirs were dug throughout the history of the region, likely from the Early or Intermediate Bronze Ages until the medieval period, including periods with no stone-built remains in the region. The construction of subterranean cisterns, which calls for more resources and skill, characterize the Late Roman/Byzantine to Early Islamic period. The significance of these results for reconstructing the history of human activity in the region is also discussed.
Colon Cancer Screening Methods: 2023 Update

Colorectal cancer (CRC) is a significant cause of morbidity and mortality worldwide. National screening guidelines have been implemented to identify and remove precancerous polyps before they become cancer. Routine CRC screening is advised for people with average risk starting at age 45 because it is a common and preventable malignancy. Various screening modalities are currently in use, ranging from stool-based tests (fecal occult blood test (FOBT), fecal immunochemical test (FIT), and FIT-DNA test), radiologic tests (computed tomographic colonography (CTC), double contrast barium enema), and visual endoscopic examinations (flexible sigmoidoscopy (FS), colonoscopy, and colon capsule endoscopy (CCE)) with their varying sensitivity and specificity. Biomarkers also play a vital role in assessing the recurrence of CRC. This review offers a summary of the current screening options, including biomarkers available to detect CRC, highlighting the benefits and challenges encompassing each screening modality.
An Update on Clinical Trials and Potential Therapeutic Strategies in T-Cell Acute Lymphoblastic Leukemia

Current therapies for T-cell acute leukemia are based on risk stratification and have greatly improved the survival rate for patients, but mortality rates remain high owing to relapsed disease, therapy resistance, or treatment-related toxicities/infection. Patients with relapsed disease continue to have poor outcomes. In the past few years, newer agents have been investigated to optimize upfront therapies for higher-risk patients in the hopes of decreasing relapse rates. This review summarizes the progress of chemo/targeted therapies using Nelarabine/Bortezomib/CDK4/6 inhibitors for T-ALL in clinical trials and novel strategies to target NOTCH-induced T-ALL. We also outline immunotherapy clinical trials using monoclonal/bispecific T-cell engaging antibodies, anti-PD1/anti-PDL1 checkpoint inhibitors, and CAR-T for T-ALL therapy. Overall, pre-clinical studies and clinical trials showed that applying monoclonal antibodies or CAR-T for relapsed/refractory T-ALL therapy is promising. The combination of target therapy and immunotherapy may be a novel strategy for T-ALL treatment.
A review and comparison of surface incident shortwave radiation from multiple data sources: satellite retrievals, reanalysis data and GCM simulations

ABSTRACT Surface incident shortwave radiation (Rs ) can promote the circulation of substance and energy, and the accuracy of its estimation is of great significance for climate studies. The Rs can be acquired from satellite retrievals, reanalysis predictions and general circulation model (GCM) simulations. Although Rs estimates have been evaluated and compared in previous studies, most of them focus on evaluating the Rs estimates over specific regions using ground measurements from limited stations. Therefore, it is essential to comprehensively validate Rs estimates from multiple data sources. In this study, ground measurements of 690 stations from BSRN, GEBA, CMA, GC-NET and buoys were employed to validate the Rs estimates from seven representative products (GLASS, GEWEX-SRB, CERES-EBAF, ERA5, MERRA2, CFSR and CMIP6). The validation results indicated that the selected products overestimated Rs globally, with biases ranged from 0.48 to 21.27 W/m2. The satellite retrievals showed relatively better accuracy among seven datasets compared to ground measurements at the selected stations. Moreover, the selected seven products were all in poor accuracy at high-latitude regions with RMSEs greater than 50 W/m2. The long-term variation trends were also analyzed in this study.
Synthesis and Characterization of Biodegradable Poly(vinyl alcohol)-Chitosan/Cellulose Hydrogel Beads for Efficient Removal of Pb(II), Cd(II), Zn(II), and Co(II) from Water

Globally, water contamination by heavy metals is a serious problem that affects the environment and human health. Adsorption is the most efficient way of water treatment for eliminating heavy metals. Various hydrogels have been prepared and used as adsorbents to remove heavy metals. By taking advantage of poly(vinyl alcohol) (PVA), chitosan (CS), cellulose (CE), and the process for physical crosslinking, we propose a simple method to prepare a PVA-CS/CE composite hydrogel adsorbent for the removal of Pb(II), Cd(II), Zn(II) and Co(II) from water. Structural analyses of the adsorbent were examined by Fourier transform infrared (FTIR) spectroscopy, scanning electron microscopy-energy dispersive X-ray (SEM-EDX) analysis, and X-ray diffraction (XRD). PVA-CS/CE hydrogel beads had a good spherical shape together with a robust structure and suitable functional groups for the adsorption of heavy metals. The effects of adsorption parameters such as pH, contact time, adsorbent dose, initial concentration of metal ions, and temperature on the adsorption capacity of PVA-CS/CE adsorbent were studied. The adsorption characteristics of PVA-CS/CE for heavy metals may be completely explained by pseudo-second-order adsorption and the Langmuir adsorption model. The removal efficiency of PVA-CS/CE adsorbent for Pb(II), Cd(II), Zn(II), and Co(II) was 99, 95, 92, and 84%, respectively, within 60 min. The heavy metal’s hydrated ionic radius may be crucial in determining the adsorption preference. After five consecutive adsorption–desorption cycles, the removal efficiency remained over 80%. As a result, the outstanding adsorption-desorption properties of PVA-CS/CE can potentially be extended to industrial wastewater for heavy metal ion removal.
Assessment of pharmaceutical care services provided to HIV infected patients on antiretroviral therapy in Rivers state, Nigeria

Pharmaceutical care of HIV infected persons on antiretroviral therapy is pertinent in optimal management to achieve viral suppression and improve immune status. The objective of the study was to assess pharmaceutical care services provided to HIV infected patients on antiretroviral therapy. A prospective, cross-sectional study was carried out among 217 pharmacists giving pharmaceutical care services to HIV positive patients in Rivers State, Nigeria. Data collection tool was a structured, pre-tested questionnaire used to assess pharmaceutical care services carried out by pharmacists. The data collected were analyzed using SPSS version 20 and Microsoft Excel. Most of the respondents were female (62.8%). More than half (59.9%) of the subjects involved in provision of pharmaceutical care to HIV infected patients were practicing in the hospital setting. Most respondents (77.8%) did not monitor for drug therapy problems (DTPs), while most (89.9%) did not document interventions to identified drug therapy problems. Majority of respondents (90.3%) established rapport with patients to improve adherence. Most respondents (72.5%) had regular supply of antiretroviral drugs in their health facility. Pharmaceutical care services rendered to HIV infected patients on antiretroviral therapy was sub-optimal. Identification of DTPs and respective interventions, involvement in general patient management, and documentation of activities were the most affected.
Specification Tests for Dynamic Models Using Multipliers

Extending the multiplier central limit theorem and resampling bootstrap to statistics and empirical processes of pseudo-observations, it is shown how to build asymptotically independent copies of statistics and empirical processes to perform statistical tests. Application to parametric and semi-parametric specification tests for the innovations of dynamic models are given. Finally, the performance of some multipliers-based tests is studied for testing the null hypothesis of Gaussian innovations for GARCH models.
Spindle cell thymoma and its histological mimickers

Spindle cell thymomas are the most common spindle cell neoplasms of the anterior mediastinum. These tumors belong to the group of thymic epithelial neoplasms and are known for their wide histomorphologic spectrum. This histological heterogeneity is the reason why unequivocal diagnosis can be challenging, especially when dealing with small biopsy material. Conversely, less conventional patterns of the tumor may also pose significant diagnostic problems in resected material and the differential diagnosis often includes other spindle cell neoplasms that are known to arise in the mediastinal cavity. These can be of variable origin and may share overlapping pathological features with spindle cell thymoma. Since spindle cell thymomas are tumors that primarily affect the adult population and predominantly arise from the thymic gland in the anterior mediastinum, this review will focus on the differential diagnosis with other spindle cell neoplasms that share similar demographic characteristics and, for the most part, originate from the anterior mediastinal compartment. These include other epithelial spindle cell tumors of thymic origin (sarcomatoid thymic carcinoma and spindle cell carcinoid tumor), mesenchymal neoplasms [solitary fibrous tumor (SFT), synovial sarcoma, and dedifferentiated liposarcoma] and various other tumors with spindle cell morphology, that may occasionally involve the anterior mediastinum. The clinical, pathological, immunohistochemical and molecular hallmarks of these lesions will be discussed and useful tips for the differential diagnosis with spindle cell thymoma will be provided.
Temperature-Responsive Hydrogel for Silver Sulfadiazine Drug Delivery: Optimized Design and In Vitro/In Vivo Evaluation

Response surface methodology (RSM) was applied to optimise a temperature-responsive hydrogel formulation synthesised via the direct incorporation of biocellulose, which was extracted from oil palm empty fruit bunches (OPEFB) using the PF127 method. The optimised temperature-responsive hydrogel formulation was found to contain 3.000 w/v% biocellulose percentage and 19.047 w/v% PF127 percentage. The optimised temperature-responsive hydrogel provided excellent LCST near to the human body surface temperature, with high mechanical strength, drug release duration, and inhibition zone diameter against Staphylococcus aureus. Moreover, in vitro cytotoxicity testing against human epidermal keratinocyte (HaCaT) cells was conducted to evaluate the toxicity of the optimised formula. It was found that silver sulfadiazine (SSD)-loaded temperature-responsive hydrogel can be used as a safe replacement for the commercial SSD cream with no toxic effect on HaCaT cells. Last, but not least, in vivo (animal) dermal testing—both dermal sensitization and animal irritation—were conducted to evaluate the safety and biocompatibility of the optimised formula. No sensitization effects were detected on the skin applied with SSD-loaded temperature-responsive hydrogel indicating no irritant response for topical application. Therefore, the temperature-responsive hydrogel produced from OPEFB is ready for the next stage of commercialisation.
Scaling up support vector machines

Kernel methods, such as support vector machines (SVMs), have been successfully used in various aspects of machine learning problems, such as classification, regression, and ranking. Many of them are formulated as quadratic programming (QP) problems, which take O(m3) time and O(m2) space complexities, where m is the training set size. It is thus computationally infeasible on massive data sets. By observing that practical SVM implementations only approximate the optimal solution by an iterative strategy, I scale up kernel methods by exploiting such "approximateness" in this thesis. First, I show that SVM classification problems can be equivalently formulated as minimum enclosing ball (MEB) problems in computational geometry. Then, by adopting an efficient approximate MEB algorithm, I obtain provably approximately optimal solutions with the idea of core-sets. My proposed Core Vector Machine (CVM) algorithm can be used with nonlinear kernels and has a time complexity that is linear in m and a space complexity that is independent of m for a fixed approximation factor (1 + e) 2. Experiments on large real-world data sets demonstrate that the CVM is as accurate as existing SVM implementations but is much faster and can handle much larger data sets than existing scale-up methods. By generalizing the underlying MEB problem as the center-constrained minimum enclosing ball (CCMEB) problem, I extend the CVM algorithm to the regression and ranking setting. Moreover, the condition on the kernel function is relaxed. Thus, the enhanced CVM algorithm can be used with any linear/nonlinear kernels. Finally, I introduce the enclosing ball (MEB) problem where the ball's radius is fixed and thus does not have to be minimized. I develop efficient (1 + e)- approximation algorithms that are simple to implement and do not require any sophisticated numerical solver. For the Gaussian kernel in particular, a suitable choice of this (fixed) radius is easy to determine, and the center obtained from the (1+e)-approximation of this EB problem is close to the center of the corresponding MEB. Experimental results show that the proposed algorithm has accuracies comparable to the other large-scale SVM implementations, but can handle very large data sets and is even faster than the CVM in general.
Performance Evaluation of Radiation-Shielding Materials and Process Technology for Manufacturing Skin Protection Cream

Personnel using X-ray devices, the main source of radiation in medical institutions, are primarily affected by scattered rays. When interventionists use radiation for examinations/treatments, their hands may enter the radiation-generating area. The shielding gloves used for protection against these rays restrict movement and cause discomfort. Here, a shielding cream that directly adheres to the skin was developed and examined as a personal protective device; further, its shielding performance was verified. Bismuth oxide and barium sulfate were selected as shielding materials and comparatively evaluated in terms of thickness, concentration, and energy. With increasing wt% of the shielding material, the protective cream became thicker, resulting in improved protection. Furthermore, the shielding performance improved with increasing mixing temperature. Because the shielding cream is applied to the skin and has a protective effect, it must be stable on the skin and easy to remove. During manufacturing, the bubbles were removed, and the dispersion improved by 5% with increasing stirring speed. During mixing, the temperature increased as the shielding performance increased by 5% in the low-energy region. In terms of the shielding performance, bismuth oxide was superior to barium sulfate by approximately 10%. This study is expected to facilitate the mass production of cream in the future.