Miracle-dz/UniFAR-FTUs huggingface dataset:
Prevalence of Non-Alcoholic Fatty Liver Disease in Urban Adult Population in a Tertiary Care Center, Chennai

Background: Non-alcoholic fatty liver disease (NAFLD) is becoming one of the most common liver diseases among the Indian population. The predisposing factors for NAFLD are diet, lifestyle modifications, and lack of exercise. There is a paucity of research on NAFLD in the South Indian population. Hence, the present study aimed to assess the prevalence of NAFLD among the urban adult population in Chennai. Material and Methods: This analytical cross-sectional study was conducted in General Medicine outpatient departments at a tertiary care center in Chennai. The study included 510 non-alcoholic adults (both male and female) aged between 21 and 40 years. Ultrasonography was performed to rule out fatty liver in all participants. All the results obtained were statistically analyzed using SPSS software version 22.0. The frequency was given in percentage. Results: The proportion of participants who screened positive for NAFLD was 61.5%. The participants with higher body mass index (BMI) were found to be significantly 23.09 times higher risk of developing NAFLD. An increase in age was also found to be a predictor of NAFLD. This study also supports that males are more prone to develop NAFLD and are at a 1.59% higher risk of developing the disease than females. Conclusion: Fatty liver has become one of the common non-communicable diseases in India, the high prevalence of NAFLD in the present study supports it. Therefore, people should have regular screening and diagnosis to rule out fatty liver disease. Proper diet patterns and exercise must be followed to prevent fatty liver.
Economic growth effects of de facto and de jure trade globalization in ECOWAS

This paper examines the dynamics of trade globalization by analysing and comparing the economic growth effect of overall trade globalization with the growth effects of de facto and de jure trade globalization in the economic community of west African states (ECOWAS). Using fixed effects and random effects models, we separate the de facto measure of trade globalization from the de jure measure to prove that de facto trade globalization significantly and positively contributes to economic growth in ECOWAS, whereas de jure trade globalization does not. We also use pooled mean group estimates to prove that the growth effect of de facto trade globalization is significant only in the short run. By implication, relying only on the results of overall trade globalization can be misleading for policymakers, considering that the de facto and de jure measures of trade globalization yield different growth results. The findings of this study can aid policymakers within the region in identifying proper measures and tailoring trade policies to gain reasonable competitive advantage among other economic communities.
A SURVEY on MCDM APPROACHES for MARITIME PROBLEMS

The maritime industry is a worldwide area of work where critical decisions are made in critical situations. The fact that decision-making is based on a scientific and mathematical basis has been in academic authorities' attendance area for the last five decades. In this study, a literature review has been conducted on the use of decision-making techniques in maritime practices. In the literature survey, Multi-Criteria Decision-Making (MCDM) methods have been examined, studies in Turkey and the International area carded; weights, distributions, usage reasons, advantages, and disadvantages of methods determined based on studies have been comparatively studied. The main aim of this paper is to statistically compare the quality and quantity of the papers published on the decision-making techniques used in maritime in Turkey and the International area. In addition to MCDM techniques, other mathematical methods used in shipping are also included in the study. The evaluation of other mathematical methods and their comparison with the commonly used methods have been made under a subtitle in this paper.
Clinical Utility of Mobocertinib in the Treatment of NSCLC – Patient Selection and Reported Outcomes

Abstract Mobocertinib is an oral tyrosine kinase inhibitor (TKI) that selectively targets epidermal growth factor receptor exon 20 insertion (EGFRex20ins) mutations. It is a structural analog of the third-generation TKI osimertinib, which targets EGFR T790M mutant non-small cell lung cancer (NSCLC); however, mobocertinib gains selectivity for EGFRex20ins mutants over wild type (WT) by interacting with the C790 gatekeeper residue of EGFR. This is accomplished via a carboxylated isopropyl ester moiety at the C5-position of mobocertinib’s central pyrimidine core. In Phase 1/2 dose-escalation and dose-expansion studies, mobocertinib was found to have an investigator-confirmed overall response rate (ORR) of 56% (9/16; 95% CI: 30–80%) and 25% (3/12; 95% CI: 5–57%) in patients without and with baseline brain metastasis, respectively. Median investigator-assessed progression-free survival (mPFS) was 10.2 months (95% CI: 5.6 – not reached) and 3.7 months (95% CI: 1.8–15.9) in patients without and with baseline brain metastasis, respectively. A third phase evaluated patients who had received pre-treatment with platinum-based chemotherapy (PPP) and included an extension cohort (EXCLAIM cohort) which evaluated patients treated previously with 1 or 2 lines of therapy. An Independent Review Committee (IRC) found both cohorts to have similar outcomes in terms of ORR, median time to response, mPFS, and disease progression or death. The treatment-emergent adverse events (TEAE) related to mobocertinib are similar to other EGFR inhibitors and are predominately gastrointestinal (eg diarrhea, nausea, vomiting) and cutaneous (eg rash). In September 2021, the FDA granted accelerated approval for mobocertinib in the treatment of patients with locally advanced or metastatic NSCLC with EGFRex20ins mutation whose disease progressed while on platinum-based chemotherapy. The present review describes data that led to the approval of mobocertinib.
A comparative study on the application of different endoscopic diagnostic methods in the differential diagnosis of benign and malignant bile duct strictures

Objective To compare the diagnostic value of cytobrush, ERCP-guided biopsy, SpyGlass direct visual impression and SpyGlass-guided biospy (SpyBite) in the differential diagnosis of benign and malignant bile duct strictures. Methods The data of 1,008 patients who were clinically diagnosed with indeterminate biliary strictures and underwent ERCP-guided biopsy, cytobrush, SpyGlass direct visual impression or SpyBite at the First Affiliated Hospital of Nanchang University between January 2010 and December 2019 were collected and analyzed retrospectively. The final diagnose was determined by surgical pathological specimen or follow-up (Malignant stricture can be identified if the stricture showed malignant progression during one year of follow-up). The differential diagnostic value of the above endoscopic diagnostic methods was evaluated by means of sensitivity, specificity, accuracy, positive predictive value, negative predictive value, etc. and safety was evaluated by the incidence rate of adverse events. Results In terms of sensitivity, standard biopsy group (48.6%) and SpyBite group (61.5%) were significantly higher than cytobrush group (32.0%), and visual impression group (100%) was significantly higher than any other group. As far as specificity was concerned, cytobrush group (99.0%), standard biopsy group (99.3%) and the SpyBite group (100%) were significantly higher than visual impression (55.6%), but there was no statistical difference among the three groups above. As far as accuracy was concerned, standard biopsy group (65.3%), and SpyBite group (80.0%) were significantly higher than cytobrush group (44.4%), and SpyBite group (80.0%) was significantly higher than visual impression group (54.8%). In terms of safety, visual impression group and SpyBite group were significantly higher than cytobrush group and standard biopsy group in post-ERCP cholangitis. Conclusion SpyBite combined with SpyGlass-guided visual impression was better for differential diagnosis of benign and malignant bile duct strictures in terms of sensitivity and accuracy compared with conventional endoscopic diagnostic methods such as cytobrush and standard biopsy. Furthmore, the incidence rates of adverse events after SpyGlass examination was similar to those after conventional endoscopic diagnostic methods except for higher cholangitis, which could be controlled by antibiotics and might be avoided by adequate biliary drainage.
Distinct topographic organization and network activity patterns of corticocollicular neurons within layer 5 auditory cortex

The auditory cortex (AC) modulates the activity of upstream pathways in the auditory brainstem via descending (corticofugal) projections. This feedback system plays an important role in the plasticity of the auditory system by shaping response properties of neurons in many subcortical nuclei. The majority of layer (L) 5 corticofugal neurons project to the inferior colliculus (IC). This corticocollicular (CC) pathway is involved in processing of complex sounds, auditory-related learning, and defense behavior. Partly due to their location in deep cortical layers, CC neuron population activity patterns within neuronal AC ensembles remain poorly understood. We employed two-photon imaging to record the activity of hundreds of L5 neurons in anesthetized as well as awake animals. CC neurons are broader tuned than other L5 pyramidal neurons and display weaker topographic order in core AC subfields. Network activity analyses revealed stronger clusters of CC neurons compared to non-CC neurons, which respond more reliable and integrate information over larger distances. However, results obtained from secondary auditory cortex (A2) differed considerably. Here CC neurons displayed similar or higher topography, depending on the subset of neurons analyzed. Furthermore, specifically in A2, CC activity clusters formed in response to complex sounds were spatially more restricted compared to other L5 neurons. Our findings indicate distinct network mechanism of CC neurons in analyzing sound properties with pronounced subfield differences, demonstrating that the topography of sound-evoked responses within AC is neuron-type dependent.
Unsteady thrust, lift and moment of a two-dimensional flapping thin airfoil in the presence of leading-edge vortices: a first approximation from linear potential theory

The effect of a leading-edge vortex (LEV) on the lift, thrust and moment of a two-dimensional heaving and pitching thin airfoil is analysed within the unsteady linear potential theory. First, general expressions that take into account the effect of any set of unsteady point vortices interacting with the oscillating foil and unsteady wake are derived. Then, a simplified analysis, based on the Brown–Michael model, of the initial stages of the growing LEV from the sharp leading edge during each half-stroke is used to obtain simple expressions for its main contribution to the unsteady lift, thrust and moment. It is found that the LEV contributes to the aerodynamic forces and moment provided that a pitching motion exists, while its effect is negligible, in the present approximation, for a pure heaving motion, and for some combined pitching and heaving motions with large phase shifts which are also characterized in the present work. In particular, the effect of the LEV is found to decrease with the distance of the pivot point from the trailing edge. Further, the time-averaged lift and moment are not modified by the growing LEVs in the present approximation, and only the time-averaged thrust force is corrected, decreasing slightly in most cases in relation to the linear potential results by an amount proportional to $a_{0}^{2}k^{3}$ for large $k$ , where $k$ is the reduced frequency and $a_{0}$ is the pitching amplitude. The time-averaged input power is also modified by the LEV in the present approximation, so that the propulsion efficiency changes by both the thrust and the power, these corrections being relevant only for pivot locations behind the midchord point. Finally, the potential results modified by the LEV are compared with available experimental data.
ANALYSIS OF ELEMENTARY SCHOOL STUDENTS' CRITICAL THINKING SKILLS IN THE SUBJECTS OF NATURAL SCIENCE AND SOCIAL STUDIES

The ability to think critically is a skill that students need to cope with the challenges of today's world. The aim of this study is to analyze the critical thinking skills of fourth-grade students in science materials at SD Islam Ummina and SDN 1 Tunjungan for the 2022/2023 academic year. This research employs a quantitative descriptive method, with data collected by providing High Order Thinking Skills (HOTS) questions with critical thinking indicators related to science material to 52 students of grade IV SD. The results of the PAP analysis on the final test showed that 7 students (13%) had high critical thinking skills, 5 students (10%) had good critical thinking skills, 18 students (35%) had sufficient critical thinking skills, and 22 students (42%) had low critical thinking skills. Furthermore, in the distribution of student answers, the minimum score was 110 with a percentage of 21% for question number 7, which utilized type C5 questions with complex multiple-choice formats. Thus, the students' ability to solve questions at levels C4, C5, and C6 is still low. Based on these results, it can be concluded that the critical thinking skills of fourth-grade students at SD Islam Ummina and SDN 1 Tunjungan are still low.
Effect of the use of inorganic- based photoluminescent materials in solar energy devices application

The dynamic processes that take place in life require energy. The main convenient source of energy even in living tissue are hydrocarbons. This is due to the high-carbon based energy source that eventually converts fossil fuels. The preferred fuels as the primarily and industrial fuel contribute to the observed negative effects which emit pollutants to our environments and result to global warming. To mitigate such energy dependence, solar radiation has been exploited to produce clean energy through the use of photovoltaic cells. Nevertheless, natural radiation varies depending on the season of the year. This study investigated the properties of inorganic materials that support fluorescence after the source of light has been withdrawn. The minerals Sb/Ca/Mn/Ag were prepared hydrothermally to cultivate luminescent properties. The resulting products were characterized using Fourier Transformed Infrared (FTIR) spectroscopy and then applied to extend radiation in a photoactive material of a photocell. Optimal values of the prepared luminescent substance were established to produce the best generated potential in the fabricated solar cells when the natural radiation was withdrawn. Established receptive layer composites (KI/I2: CX) were inserted into a molding dice on top of the photosensitive layer and joined together by pressing. The ensued inorganic luminescent cells optical characteristics were observed under UV radiation (320 - 400 nm) wavelength which produced sequential varying colorations from brown, light blue, blue to red before diminishing gradually as the incident radiation was removed. The open circuit potential voltage (VOC) and current density (JSC) generated parameters were observed. The (0.45, 0.4, and 0.086) V residue potential resulted due to shifting of IR by SbNO3, Sb-PO4, Sb-CO3 and Sb-O luminescent materials. The dopants had promising properties for radiation delay in photo voltaic devices application.
Circular LSTM for Low-Dose Sinograms Inpainting

Computed tomography (CT) is usually accompanied by a long scanning time and substantial patient radiation exposure. Sinograms are the basis for constructing CT scans; however, continuous sinograms may highly overlap, resulting in extra radiation exposure. This paper proposes a deep learning model to inpaint a sparse-view sinogram sequence. Because a sinogram sequence around the human body is circular in nature, we propose a circular LSTM (CirLSTM) architecture that feeds position-relevant information to our model. To evaluate the performance of our proposed method, we compared the results of our inpainted sinograms with ground truth sinograms using evaluation metrics, including the peak signal-to-noise ratio (PSNR) and structural similarity index measure (SSIM). The SSIM values for both our proposed method and the state-of-the-art method range from 0.998 to 0.999, indicating that the prediction of structures is not challenging for either method. Our proposed CirLSTM achieves PSNR values ranging from 49 to 52, outperforming all the other compared methods. These results demonstrate the feasibility of using only interleaved sinograms to construct a complete sinogram sequence and to generate high-quality CT images. Furthermore, we validated the proposed model across different body portions and CT machine models. The results show that CirLSTM outperforms all other methods in both the across-body segment validation and across-machine validation scenarios.
The evolution of DARWIN: current status of wind models for AGB stars

Abstract The slow, dense winds observed in evolved asymptotic giant branch (AGB) stars are usually attributed to a combination of dust formation in the dynamical inner atmosphere of these stars and momentum transfer from stellar photons interacting with the newly formed dust particles. Wind models calculated with the DARWIN code, using this mass-loss scenario, have successfully produced outflows with dynamical and photometric properties compatible with observations, for both C-type and M-type AGB stars. Presented here is an overview of the DARWIN models currently available and what output these models produce, as well as future plans.
Muscular and Kinematic Responses to Unexpected Translational Balance Perturbation: A Pilot Study in Healthy Young Adults

Falls and fall-related injuries are significant public health problems in older adults. While balance-controlling strategies have been extensively researched, there is still a lack of understanding regarding how fast the lower-limb muscles contract and coordinate in response to a sudden loss of standing balance. Therefore, this pilot study aims to investigate the speed and timing patterns of multiple joint/muscles’ activities among the different challenges in standing balance. Twelve healthy young subjects were recruited, and they received unexpected translational balance perturbations with randomized intensities and directions. Electromyographical (EMG) and mechanomyographical (MMG) signals of eight dominant-leg’s muscles, dominant-leg’s three-dimensional (3D) hip/knee/ankle joint angles, and 3D postural sways were concurrently collected. Two-way ANOVAs were used to examine the difference in timing and speed of the collected signals among muscles/joint motions and among perturbation intensities. This study has found that (1) agonist muscles resisting the induced postural sway tended to activate more rapidly than the antagonist muscles, and ankle muscles contributed the most with the fastest rate of response; (2) voluntary corrective lower-limb joint motions and postural sways could occur as early as the perturbation-induced passive ones; (3) muscles reacted more rapidly under a larger perturbation intensity, while the joint motions or postural sways did not. These findings expand the current knowledge on standing-balance-controlling mechanisms and may potentially provide more insights for developing future fall-prevention strategies in daily life.
Preparation of Complementary Food for Infants and Young Children with Beef Liver: Process Optimization and Storage Quality

In this study, fuzzy mathematics and response surface modeling were applied to optimize the preparation process of beef liver paste and characterize the proximate composition, sensory and physicochemical qualities, and in vitro simulated digestive properties while refrigerated at 0–4 °C (0, 3, 7, 15, 30, 45, and 60 days). The results showed that the optimal preparation process was 4.8% potato starch, 99.4% water, 10.2% olive oil, and a 3:2 ratio of chicken breast and beef liver. The beef liver paste prepared contained essential amino acids for infants and children, with a protein content of 10.29 g/100 g. During storage, the pH of the beef liver paste decreased significantly (p < 0.05) on day 7, texture and rheological properties decreased significantly after 30 days, a* values increased, L* and b* values gradually decreased, and TVB-N and TBARS values increased significantly (p < 0.05) on day 7 but were below the limit values during the storage period (TVB-N value ≤ 15 mg/100 g, TBARS value ≤ 1 mg/Kg). In vitro simulated digestion tests showed better digestibility and digestive characteristics in the first 15 days. The results of this study provide a reference for the development of beef liver products for infant and child supplementation.
The Comparison of Dexmedetomidine to Dexamethasone as Adjuvants to Bupivacaine in Ultrasound-Guided Infraclavicular Brachial Plexus Block in Upper Limb Surgeries

Background The clinical utility of adjuvants with local anesthesia produces an excellent nerve block with prolonged duration and faster onset. Brachial plexus block is widely used nowadays in patients undergoing upper limb surgery There are several approaches to achieve brachial plexus block such as interscalene, supraclavicular, infraclavicular, and axillary. The objective of this study is to compare the effectiveness of dexamethasone to dexmedetomidine as adjuvants to bupivacaine in patients undergoing ultrasound-guided infraclavicular brachial plexus (USG-ICBP) block. Methods A randomized, prospective, double-blind study was undertaken on the patients posted for upper limb surgeries under ultrasound-guided infraclavicular brachial plexus block. Sixty patients with the American Society of Anesthesiologists (ASA) classes I and II were randomly allocated into two groups. Group A received 25 mL of 0.5% bupivacaine and 1.5 mL (6 mg) of dexamethasone, and group B received 25 mL of 0.5% bupivacaine and 0.75 mL (75 mcg) of dexmedetomidine along with 0.75 mL of 0.9% normal saline (NS). Student’s t test or Mann-Whitney test and chi-square test were used for statistical analysis. Results The onset of sensory block was significantly faster in the patients in group B as compared to the patients in group A. In terms of the duration of the block, sensory and motor blocks were maintained for a significantly longer duration in the group A patients as compared to those in group B. Moreover, the duration of postoperative analgesia was significantly longer-lasting in the group A patients. In terms of adverse effects, procedure-related complications such as the failure of the block and inadequate block were comparable across the groups. However, drug-related adverse effects were significantly more common in group B. Conclusion As compared to 75 mcg of dexmedetomidine, the addition of 6 mg of dexamethasone as adjuvant to 25 mL of 0.5% bupivacaine resulted in significantly longer-lasting sensory and motor blocks, postoperative analgesia, and a delayed time for first rescue analgesia without increasing undue adverse effects. Dexmedetomidine use is associated with more sedation as compared to dexamethasone.