Miracle-dz/UniFAR-FTUs huggingface dataset:
Developing Classroom Assessment Tool using Learning Management System-based Computerized Adaptive Test in Vocational High Schools

Computers have taken on a large role in education, including testing and evaluation. Traditional tests that aren't comprehensive and don't distinguish between students' beginning talents lead to measurement findings that aren't representative of their true abilities. This study aims to develop and test assessment tool eligibility class that is used as an LMS-based adaptive. This type of research includes development research. The respondents of this study were experts who assessed the validation and students of SMK Electrical Power Installation Engineering Expertise Competencies. The data analysis technique used item response theory, classical test theory and descriptive statistics. Item analysis using the Rasch Model showed 10 items were not fit and the remaining 50 items were fit. Classical test theory analysis items with less validity there are 0 items, moderate there are 55 items, and high there are 5 items, with an Alpha reliability of 0.934. The attitude questionnaire developed consists of 8 items. There are 0 items with less validity, 6 items being moderate, and 2 items high, with an Alpha reliability of 0.731. The developed observation guide contains 16 observations. Items with less validity have 0 items, while there are 15 items, and 1 item high. The use of CAT-assisted learning management systems on research tools greatly facilitates teachers in conducting research accurately and practically.
Seizures in PPT1 Knock-In Mice Are Associated with Inflammatory Activation of Microglia

Infantile neuronal ceroid lipofuscinosis (INCL), the most severe form of neuronal ceroid lipofuscinoses, is caused by mutations in the lysosomal enzyme palmitoyl protein thioesterase 1 (PPT1). Typical symptoms of this disease include progressive psychomotor developmental retardation, visual failure, seizures, and premature death. Here, we investigated seizure activity and relevant pathological changes in PPT1 knock-in mice (PPT1 KI). The behavior studies in this study demonstrated that PPT1 KI mice had no significant seizure activity until 7 months of age, and local field potentials also displayed epileptiform activity at the same age. The expression levels of Iba-1 and CD68 demonstrated, by Western blot analysis, the inflammatory cytokine TNF-α content measured with enzyme-linked immunosorbent assay, and the number of microglia demonstrated by immunohistochemistry (IHC) were significantly increased at age of 7 months, all of which indicate microglia activation at an age of seizure onset. The increased expression of GFAP were seen at an earlier age of 4 months, and such an increase reached its peak at age of 6 months, indicating that astrocyte activation precedes microglia. The purinergic P2X7 receptor (P2X7R) is an ATP-sensitive ionic channel that is highly expressed in microglia and is fundamental to microglial activation, proliferation, cytokines release and epilepsy. We show that the ATP concentration in hippocampal tissue in PPT1 KI mice was increased using an enhanced ATP assay kit and demonstrated that the antagonist of P2X7R, A-438079, significantly reduced seizures in PPT1 KI mice. In contrast to glial cell activation and proliferation, a significant reduction in synaptic proteins GABAAR was seen in PPT1 KI mice. These results indicate that seizure in PPT1 KI mice may be associated with microglial activation involved in ATP-sensitive P2X7R signaling and impaired inhibitory neurotransmission.
Local and Regional Therapies for Hepatocellular Carcinoma and Future Combinations

Simple Summary Percutaneous interventional radiological techniques offer many alternatives for treatment of Hepatocellular Carcinoma (HCC) using local anesthesia and sedation. These methods aim to destroy the malignant tumors locally without affecting the non-malignant liver. In this way, complications are kept low and patient recovery is quick. Indications depend on tumor size, type and stage, as well as patient’s condition, liver function and co-morbidities. In recent years, a lot of research has been made in combining such approaches with immune therapy, but there is still much work to be done. This manuscript tries to analyze where we stand today and explain, using a comprehensive algorithm, the treatment options for each different clinical condition. Abstract Background: Hepatocellular carcinoma (HCC) can be treated by local and regional methods of percutaneous interventional radiological techniques. Indications depend on tumor size, type and stage, as well as patient’s condition, liver function and co-morbidities. According to international classification systems such as Barcelona Clinic Liver Cancer (BCLC) classification, very early, early or intermediate staged tumors can be treated either with ablative methods or with transarterial chemoembolization (TACE), depending on tumor characteristics. The combination of both allows for individualized forms of treatment with the ultimate goal of improving response and survival. In recent years, a lot of research has been carried out in combining locoregional approaches with immune therapy. Although recent developments in systemic treatment, especially immunotherapy, seem quite promising and have expanded possible combined treatment options, there is still not enough evidence in their favor. The aim of this review is to provide a comprehensive up-to-date overview of all these techniques, explaining indications, contraindications, technical problems, outcomes, results and complications. Moreover, combinations of percutaneous treatment with each other or with immunotherapy and future options will be discussed. Use of all those methods as down-staging or bridging solutions until surgery or transplantation are taken into consideration will also be reviewed. Conclusion: Local and regional therapies remain a mainstay of curative and palliative treatment of patients with HCC. Currently, evidence on potential combination of the local and regional treatment options with each other as well as with other treatment modalities is growing and has the potential to further individualize HCC therapy. To identify the most suitable treatment option out of these new various options, a repeated interdisciplinary discussion of each case by the tumor board is of utmost importance.
Accounting Comparability and Earnings Management Strategies: Evidence from Southeast Asian Countries

ABSTRACT We examined the effect of accounting comparability on the use of accrual earnings management (AEM) and real earnings management (REM) among five members of the Association of Southeast Asian Nations. Analyzing 1,195 listed non-financial companies from 2014 to 2017, we find that more comparable accounting information between firms induces managers to engage in more REM and less AEM, supporting the substitute hypothesis. The results remain similar under the robustness tests. Our results suggest that reporting and legal environment factors may affect cost-benefit considerations versus incentives for using earnings management strategies.
Investigation Of Fully Grouted Roof Bolts Installed Under In Situ Conditions

• A series of 24 pull tests of bolts installed fully grouted and overcored to leave 12 inches of grouted bolt. The tests compared the pull-out performance of offset-head roof bolts with that of standard 5/8-inch bolts; • A second series of 24 tests that compared the pull-out loads obtained by bolts installed with 1 ft of resin (a Short Encapsulation Pull Test or SEPT) to that of fully grouted bolts overcored to leave only 12 inches of grouted bolt, and; • An investigation into the pressures generated during the installation of fully grouted resin bolts.
Development of the regulation of hydrobiological monitoring in circulation cooling system of the Zaporizhzhia nuclear power plant

The article proposes a new approach to solving the problem of biofouling at the facilities of the circulating cooling system of the Zaporizhzhia Nuclear Power Plant (ZNPP) by regulating hydrobiological studies. In the course of the studies, 4 species of hydrobionts were found that formed massive fouling on water supply facilities: filamentous algae Oedogonium sp. and Ulotrix zonata with a total biomass of 123.6±18.44 g/m2, tropical molluscs Melanoides tuberculata and Tarebia granifera of the Thiaridae family with a biomass of 20.09 g/m2. The shells of dead mollusks drifted along the pipes of the circulation system with the flow of water and interfered with the operation of pumping stations. Also, the blue-green algae Microcystis aeruginosa, which dominated the phytoplankton of the cooling pond, belonged to the potential bio-hindrances. The hydrobiological regulation was developed with the aim of timely detection of hydrobionts capable of active reproduction and creation of biological obstacles. It provides for four types of monitoring: current (operational), extreme (control), deployed (research) and background (hydrobiological monitoring of the Kakhovka reservoir in the zone of influence of waste warm waters). For each type of monitoring, the subjects of control (a group of hydrobionts), control parameters (species composition, abundance, biomass) and frequency of control are determined. The regulation of hydrobiological monitoring makes it possible to minimize the consequences or prevent the occurrence of accidents and emergencies in the operation of the ZNPP cooling circulation systems associated with biological obstacles, and can be used as an example for solving similar problems at other power facilities. The article also contains practical recommendations for improving the ecological state of the cooling pond and preventing the massive development of dangerous aquatic organisms by introducing biomeliorator fish with a different food spectrum into the reservoir
Plagio electrónico: la otra cara del APA

This essay regards about electronic plagiarism. It consisted in three parts. At the beginning plagiarism is approached from epistemic scope that has not direct relation with truth as adequacy through a scientific procedure looking for results related to a subject and object. Secondly it is analysed since the ethic point of view that function as penalty, rules and duties respect to an original or fraud. Later it is analysed the aesthetic aspect where can be found its complexity. Also as with originals artworks, mechanical or electronically reproduction, stripped of all singularity and open it to the new power of users participation, as Walter Banjamin stressed, sending it back to epistemic field. Finally three scenarios are presented to counteract: conservative, negotiator and open or conservative, negotiator and open or ethical scenarios. Revista Humanismo y Cambio Social. Numero 7. Ano 3. Enero - Junio 2016:8-18
A description of the male drumming call of Besdolus ventralis (Pictet, 1841) (Plecoptera: Perlodidae)

This paper gives the first description of the male drumming call of Besdolus ventralis. Based on the examination of a single male specimen of this rare stonefly species its male call is composed of 3 beat groups, each containing 3-6 beats repeated at decreasing interbeat intervals. Beat groups are separated by 184-212 ms intergroup intervals. Call duration varied between 496-549 ms at ambient air temperature 18.7-20.4 degrees of Celsius. These results show that the male call of B. ventralis is clearly different from the diphasic call of B. ravizzarum, and is rather similar to that of B. bicolor, which is the closest relative of B. ventralis regarding mitocondrial DNA sequences. The main difference between the male calls of the two species seems to be that B. ventralis produces 3-6 beats per group, while B. bicolor is reported to produce only 2 (rarely 3) beats per beat-group.
Long-Term Calculation of Predicted Environmental Concentrations to Assess the Risk of Anticancer Drugs in Environmental Waters

This study reports the consumption data for 132 anticancer drugs in Catalonia (NE Spain) during the period of 2013–2017 and calculates the predicted environmental concentrations (PECs) in wastewater effluents and rivers. This long-term analysis can determine the evolution of drugs present in the environment according to prescriptions and serve as an adequate tool to determine their presence and impact. Data showed that out of 132 compounds prescribed, 77 reached wastewater effluents, which accounted for the most consumed, those excreted in the highest doses, and the least biodegradable. Once diluted in receiving river waters, only mycophenolic acid and hydroxycarbamide had PEC values higher than 10 ng L−1, which is the value set by the European Medicines Agency (EMA) to carry out further risk assessment. It was also observed that compounds present in river water are those that can pose a high risk, given their persistence and capability to bioaccumulate. Therefore, this study shows that the estimation of PEC, together with physico-chemical properties of detected compounds, is a useful tool to determine the long-term presence and fate of this new class of emerging contaminants.
Comparison of Nutritional Profiles of Super Worm (Zophobas morio) and Yellow Mealworm (Tenebrio molitor) as Alternative Feeds Used in Animal Husbandry: Is Super Worm Superior?

Simple Summary Currently, the food industry is facing numerous problems related to the increase in the global human population resulting in an increase in the demand for livestock. Animal feed production, as the chain leader of food production, needs to reduce the utilization of commonly used feeds, such as soybean meal and fish meal, and replace them with more sustainable ones. The utilization of insects as an alternative sustainable feed in the upcoming years can be one of the solutions. Optimization of rearing conditions, which includes the choice of insect species, time of harvest, and proper insect diet, is highly desirable for wider insect mass production. Along with the optimization of rearing conditions, insect producers will be able to obtain the desirable biomass and nutritive composition of insect products with the minimization of production costs. With their desirable nutritional composition, super worms could be used in extended mass production. Additionally, in animal feed production, super worms and yellow mealworms can be used as a nutritional source and a promising alternative to traditional feed ingredients. However, the optimization of the rearing conditions is needed for wider use in the animal feed industry. Abstract Edible insects are acknowledged as a valuable nutritional source and promising alternative to traditional feed ingredients, while the optimization of rearing conditions is required for their wider utilization in the animal feed industry. The main goal of this study was to compare and optimize the rearing conditions of the two species’ larvae and identify the most favorable nutritive composition of the full-fat larval meal. For that purpose, Tenebrio molitor (TM) and Zophobas morio (ZM) were reared on three different substrates and harvested after three time periods. An artificial neural network (ANN) with multi-objective optimization (MOO) was used to investigate the influence between the observed parameters as well as to optimize and determine rearing conditions. The optimization of the larval rearing conditions showed that the best nutritive composition of full-fat larval meal was obtained for ZM larvae reared on a mixture of cabbage, carrot and flaxseed and harvested after 104 days. The best nutritive composition contained 39.52% protein, 32% crude fat, 44.01% essential amino acids, 65.21 mg/100 g Ca and 651.15 mg/100 g P with a favorable ratio of 1.5 of n6/n3 fatty acids. Additionally, the incorporation of flaxseed in the larval diet resulted in an increase in C18:3n3 content in all samples.
EFFECT OF SIMULATED GRAVITATIONAL UNLOADING ON M. SOLEUS SATELLITE CELLS

Markers of the satellite cells terminal differentiation in m. Soleus were analyzed following different periods of gravitational unloading simulated by rats' tail-suspension. Satellite cells were cultivated in vitro. Western blotting was used to determine levels of mTORc1, phospho-p70S6K, phospho-ACC, phospho-FOXO1 and phospho-FOXO3 involved in cells proliferation and differentiation. Desmin and АМРКа1 expression was determined using PCR analysis. It was shown that 7 and 14 days of tail-suspension lead to the increased intensity of satellite cells proliferation and activities of transcription factors FOXO1 and FOXO3 in rat soleus muscle.
Warming‐to‐Cooling Reversal of Overflow‐Derived Water Masses in the Irminger Sea During 2002–2021

Shipboard hydrography along the A25‐Ovide section (2002–2018) is combined with a high‐resolution mooring array (2014–2020) and a regional fleet of Deep‐Argo floats (2016–2021) to describe temperature changes of overflow‐derived water masses in the Irminger Sea. Removing dynamical influences enables to identify a new statistically significant trend reversal in Iceland Scotland Overflow Water (ISOW) and Denmark Strait Overflow Water (DSOW) core temperatures in the mid‐2010s. A basin‐wide cooling trend of −16 ± 6 m°C yr−1 during 2016–2021—but reaching as strong as −44 ± 13 m°C yr−1 for DSOW in recent years—is found to interrupt a warming phase that was prevailing since the late 1990s. The absence of an apparent reversal in the Nordic Seas and the faster changes detected in DSOW compared to ISOW point out the entrainment of subpolar signals within the overflows near the Greenland‐Iceland‐Scotland sills as a most likely driver.
The Individual's Influence on Low-Technology Innovation: A Critical Realism Based Case Study on North-West Pakistan's Marble Sector

While 49 firm-level determinants of low-technology (LT) innovation have been identified through a systematic review of literature, only 9 amongst these are related to the key individual (owner and top manager). The extant literature does not shed much light on the in-depth dynamics behind presence or lack of LT innovation. Therefore, this study offers a much-needed understanding of the influence of small firm owners and managers on LT innovation in north-west Pakistan’s marble industry. Advocating the need for critical realism that has been an often-ignored paradigm in management research, this paper offers a unique perspective on the paradigm’s fundamental tenets which are “objects” as individuals and their roles, “mechanisms” as ways in which objects influence an event such as occurrence of LT innovation, and “causal powers” as individual-level determinants of LT innovation. A case study approach and mixed methods have been used to investigate two marble sectors. Findings reveal that the more the interests and stakes of owners and managers diverge, the lesser the instance of LT innovation. A role-ordered matrix is presented and explanations of mechanisms and causal powers are offered in terms of individuals’ professional and psychological traits and nature of business stake
Vehicle-Free Nanotheranostic Self-Assembled from Clinically Approved Dyes for Cancer Fluorescence Imaging and Photothermal/Photodynamic Combinational Therapy

Phototherapy, including photothermal therapy (PTT) and photodynamic therapy (PDT) has attracted growing attention as a noninvasive option for cancer treatment. At present, researchers have developed various “all-in-one” nanoplatforms for cancer imaging and PTT/PDT combinational therapy. However, the complex structure, tedious preparation procedures, overuse of extra carriers and severe side effects hinder their biomedical applications. In this work, we reported a nanoplatform (designated as ICG-MB) self-assembly from two different FDA-approved dyes of indocyanine green (ICG) and methylene blue (MB) without any additional excipients for cancer fluorescence imaging and combinational PTT/PDT. ICG-MB was found to exhibit good dispersion in the aqueous phase and improve the photostability and cellular uptake of free ICG and MB, thus exhibiting enhanced photothermal conversion and singlet oxygen (1O2) generation abilities to robustly ablate cancer cells under 808 nm and 670 nm laser irradiation. After intravenous injection, ICG-MB effectively accumulated at tumor sites with a near-infrared (NIR) fluorescence signal, which helped to delineate the targeted area for NIR laser-triggered phototoxicity. As a consequence, ICG-MB displayed a combinational PTT/PDT effect to potently inhibit tumor growth without causing any system toxicities in vivo. In conclusion, this minimalist, effective and biocompatible nanotheranostic would provide a promising candidate for cancer phototherapy based on current available dyes in clinic.
Improved ginseng production under continuous cropping through soil health reinforcement and rhizosphere microbial manipulation with biochar: a field study of Panax ginseng from Northeast China

ABSTRACT The production of ginseng, an important Chinese medicine crop, has been increasingly challenged by soil degradation and pathogenic disease under continuous cropping in Northeast China. In a field experiment, an Alfisol garden continuously cropped with Chinese ginseng (Panax ginseng C. A. Meyer) was treated with soil amendment at 20 t ha−1 with maize (MB) and wood (WB) biochar, respectively, compared to conventional manure compost (MC). Two years after the amendment, the rooted topsoil and ginseng plants were sampled. The changes in soil fertility and health, particularly in the soil microbial community and root disease incidence, and in ginseng growth and quality were portrayed using soil physico-chemical assays, biochemical assays of extracellular enzyme activities and gene sequencing assays as well as ginsenoside assays. Topsoil fertility was improved by 23% and 39%, ginseng root biomass increased by 25% and 27%, and root quality improved by 6% and 18% with WB and MB, respectively, compared to MC. In the ginseng rhizosphere, fungal abundance increased by 96% and 384%, with a significant and insignificant increase in bacterial abundance, respectively, under WB and MB. Specifically, the abundance of Fusarium spp. was significantly reduced by 19–35%, while that of Burkholderia spp. increased by folds under biochar amendments over MC. Relevantly, there was a significant decrease in the abundance proportion of pathotrophic fungi but a great increase in that of arbuscular mycorrhizal fungi, along with an enhanced microbial community network complexity, especially fungal community complexity, under biochar amendments. Thus, biochar, particularly from maize residue, could promote ginseng quality production while enhancing soil health and ecological services, including carbon sequestration, in continuously cropped fields.