Miracle-dz/UniFAR-FTUs huggingface dataset:
Cost-effectiveness analysis of the addition of bevacizumab to temozolomide therapy for the treatment of unresected glioblastoma

Glioblastoma, a cancer that originates from astrocytes, is the most prevalent malignant glioma in the adult population. The aim of the present study was to evaluate the cost-effectiveness of bevacizumab (BEV) as a supplement to standard temozolomide (TMZ) treatment for unresected glioblastoma. The analyzed data were from a phase II trial that showed a survival benefit following combination therapy, when compared with TMZ monotherapy. According to the clinical symptoms and disease progression, a Markov model was constructed to estimate the incremental cost-effectiveness ratio (ICER) from a Chinese societal perspective. Health outcomes were retrieved from the GENOM 009 trial, and utility parameters were obtained from published literature. Uncertainties within the model were addressed through one-way deterministic and probabilistic sensitivity analyses. The addition of BEV to TMZ therapy increased overall costs by $30,894.99, with a gain of 0.18 quality-adjusted life-years (QALYs), resulting in an ICER of $171,638.83/QALY. Both one-way sensitivity and probabilistic sensitivity analyses confirmed that BEV/TMZ co-treatment was not cost-effective in the context of a $26,508.00/QALY willingness-to-pay (WTP) threshold. The utility of the progression-free survival state had the most noticeable impact on the ICER. In summary, the combination of BEV and TMZ should not be considered a cost-effective neoadjuvant treatment option for patients with unresected glioblastoma in China, from a societal perspective. However, in view of the survival benefits conferred, an appropriate price discount or the use of medical insurance could make BEV affordable for this patient population.
Surgical management of urolithiasis and unilateral cryptorchidism in a German shephard

A four year old male German shepherd weighing around 30kg was presented with the history of anuria for the past two days and dribbling urine for the past six months. Clinical examination of animal revealed congested mucous membrane, restlessness, ptyalism, distended painful abdomen, severely dehydrated and cryptorchid. Survey radiography revealed numerous cystic and urethral calculi. Attempt of lithohydropropulsion under Xylazine sedation was unsuccessful. Under general anaesthesia a mid ventral ceiliotomy performed. Exploration of abdominal cavity revealed uroabdomen, cystorrhexis. Calculi from the bladder was removed. Prescrotal urethrotomy was performed and caliculi removed from the penile urethra. The retained testicle in the abdomen was identified and removed. The testicle in the scrotal sac was removed by prescrotal method.
Neo-adjuvant chemotherapy followed by either continuous hyper-fractionated accelerated radiation therapy week-end less or conventional chemo-radiotherapy in locally advanced NSCLC-A randomised prospective single institute study

Context: Better locoregional control and increased overall survival by continuous hyper fractionated accelerated radiotherapy have been shown in unresectable nonsmall cell lung carcinoma (NSCLC). Dose escalation and neoadjuvant chemotherapy (NACT) along with continuous hyperfractionated accelerated radiotherapy week end-less (CHARTWEL) were also tried for improved survival. In this present study, we compared the results of NACT followed by CHARTWEL against NACT followed by conventional concurrent chemo-radiation therapy. Aims: The aim of this study is to compare the locoregional control and toxicities in NSCLC Stage IIIA and B in both arms. Settings and Design: Randomized, prospective single-institutional study with a study population comprising all locally advanced unresectable NSCLC patients enrolled in 2014 at our institute. Subjects and Methods: All enrolled patients were randomized into two arms-CHARTWEL and concomitant chemo-radiotherapy (CCRT), after three weeks of the fourth cycle of NACT. In CHARTWEL arm 30 patients received two-dimensional radiotherapy (RT) 58.5 Gy/39 fr/2.5 weeks while in CCRT arm 30 received 66 Gy/33 fr/6.5 weeks. Disease response was evaluated at 6 months and toxicity assessment during and after treatment completion. Data were analyzed using tools such as percentage, mean, Chi-square test and P value. Chi-square and P value was calculated by statistical online software (http://quantpsy.org). Results: 28% of patients in study arm and 20% in control arm had complete response at 6 months after RT. Locoregional disease control was observed in 44% in study arm and 32% in control arm of patients. There was no statistical difference in grades of toxicities or overall survival (OS)/disease-free survival except persistent esophagitis Grade III seen in two patients of study arm. Conclusions: Study suggests that CHARTWEL in combination with NACT is an effective strategy to treat patients with locally advanced lung cancer with the advantage of a smaller dose and shorter duration. Although large multivariate studies still needed.
Pain from torture: assessment and management

Abstract Introduction: Survivors of torture are for many reasons at particularly high risk for inadequate assessment and management of pain. Among the many health problems associated with torture, persistent pain is frequent, particularly pain in the musculoskeletal system. The pathophysiology underlying post-torture pain is largely unknown, but pain inflicted in torture may have profound effects on neurophysiology and pain processing. Methods: A narrative review of assessment and treatment studies, informed by clinical experience, was undertaken. Results: The clinical presentation in survivors of torture shares characteristics with other chronic primary pain syndromes, including chronic widespread pain. Unfortunately, such pain is often misunderstood and dismissed as a manifestation of psychological distress, both in specialist psychosocially oriented torture services and in mainstream health care. This means that pain is at risk of not being recognized, assessed, or managed as a problem in its own right. Conclusions: The available research literature on rehabilitation for torture survivors is predominantly targeted at mental health problems, and studies of effectiveness of pain management in torture survivors are lacking. Rehabilitation is identified as a right in the UN Convention on Torture, aiming to restore as far as possible torture survivors' health and capacity for full participation in society. It is therefore important that pain and its consequences are adequately addressed in rehabilitative efforts. This article summarizes the current status on assessment and management of pain problems in the torture survivor.
Celiac Disease in First-Degree Relatives: Homozygosity of DQB1*02 and at least one copy of HLA-DQB1*02 Allele.

1. Lopes LHC, Muniz JG, Oliveira RP, et al. Celiac disease in Brazilian firstdegree relatives: the odds are five times greater for HLA DQ2 Homozygous. J Pediatr Gastroenterol Nutr 2019;68:e77–80. 2. De Silvestri A, Capittini C, Poddighe D, et al. HLA-DQ genetics in children with celiac disease: a meta-analysis suggesting a two-step genetic screening procedure starting with HLA-DQ b chains. Pediatr Res 2018;83:564–72. 3. Poddighe D, Capittini C, Gaviglio I, et al. HLA-DQB1 02 allele in children with celiac disease: potential usefulness for screening strategies. Int J Immunogenet 2019. doi:10.1111/iji.12441. [Epub ahead of print].
Association of fitness and body fatness with left ventricular mass: The Heart Health Study

Left ventricular mass (LVM) is a clinical prognostic indicator of cardiovascular disease. Left ventricular mass is associated with body size (body mass index [BMI], weight, and body surface area [BSA]). This study examined if the association between body size (weight, BMI, and BSA) and LVM is influenced by body composition and cardiorespiratory fitness in adults who are overweight or obese.
Ultrasound Diagnostics of Hemodynamic Changes in Arteriovenous Fistula for Hemodialysis: Review

The socio-economic significance of chronic kidney disease in the terminal stage is due to the fact that expensive methods of treatment are required, the number of patients on hemodialysis increases annually and most of them are of working age. The most preferred vascular access for hemodialysis treatment is an arteriovenous fistula, yet its dysfunction occurs in more than 30% of patients. Adequate long-term functioning of the fistula depends on its successful maturation, timely diagnosis and elimination of possible complications of permanent vascular access. The main method for diagnosing dysfunction of an arteriovenous fistula is duplex ultrasound, which allows determining the diameters, the state of the walls and blood vessels lumen, the access flow, identifying such complications as stenosis of inflow artery, anastomotic zone and outflow vein, fistula thrombosis, hand ischemia. Ultrasound diagnosis of vascular access complications allows for their timely correction, which increases the duration of fistula adequate functioning.
Disease Burden in Patients with Glanzmann’s Thrombasthenia: Perspectives from the Glanzmann’s Thrombasthenia Patient/Caregiver Questionnaire

Purpose Glanzmann’s thrombasthenia (GT) is a rare bleeding disorder caused by a mutation in the αIIbβ3 integrin essential for optimal platelet function and hemostasis. The aim of this study was to identify the burden of GT on patients and caregivers through better understanding of the management and psychosocial impact of this disorder. Patients and Methods Participants for this online survey were recruited using a rare disease specialty recruiter from Comprehensive Health Education Services. Data were collected from January 31 through March 12, 2019. The questionnaire was designed to collect information regarding demographics, diagnosis, treatment, and psychosocial impact. Results Of the 45 respondents (24 patients and 21 caregivers), the majority were female (58%), white (64%), and employed full-time (53%) and had no family history of GT (64%). Many patients reported significant bruising at birth (76%), and the mean age at diagnosis was 2.6 years. About half of the patients experienced 1 bleed per day, and 13% had over 500 bleeds of any severity per year. Most bleeds were skin bruising or mouth bleeds, but patients also reported joint/muscle and gastrointestinal bleeds. Most patients reported receiving a platelet transfusion (82%), and some had developed platelet refractoriness (38%) or antibodies (32%). Common treatments were antifibrinolytics (82%) and recombinant activated factor VII (rFVIIa) (42%), likely due to the presence of antibodies. Many (58%) patients experienced issues with excessive bleeding at school; 38% reported missing school as a result. Female patients struggled to find a gynecologist with knowledge of the management of GT. Most patients were satisfied with the support they receive from their current partner (65%) and their friends (76%). Conclusion Most patients with GT are diagnosed early. Patients experience considerable psychosocial impact. Patient and physician education concerning treatment alternatives and the support of the GT community are critical.
Assessment of dental caries among outdoor patients in a tertiary care hospital of Northern India

1 Associate Professor, Department of Dentistry, IIMSR Lucknow 2 Senior Resident Department of Dentistry, IIMSR 3 Associate Professor, Dental Department Govt Medical College Haldwani *Corresponding Author Dr Bharat Bhushan Associate Professor, Dental Department Govt Medical College Haldwani, India Abstract Background and Objectives: Dental caries is an irretrievable disease, with a likelihood of new lesions that continue to affect humanity. Dental caries or tooth decay is an acquired chronic infective disease process caused by the acidic by-products of bacteria inhabiting organized dental plaque or oral bio-film that, if left uninterrupted, can dissolve or demineralize the enamel surfaces of the teeth. The aim of this study was to assess the dental caries and oral health status of the outdoor patients attending a tertiary care hospital of Northern India. Materials and Methods: The present cross-sectional study was carried out in the Department of Dentistry, Integral Institute of Medical Sciences and Research, Lucknow, India. The study was carried out for a duration of six months from February 2019July 2019. Data entry and management were carried out using MS excel spreadsheet and software. Results: Out of total 3743 study subjects, 1775 (47.4%) of the study subjects had dental caries. In females, 52.5% were having dental caries and 47.5% males were suffering with dental caries. Majority of study subjects belonged to the age group equal to or above 12 years, 94.2% of them had caries. Conclusion: Despite scientific advances and the fact that it is a preventable disease, dental caries continues to be a major public health problem. Implementation of Primary prevention strategies is the need of the hour to reduce the burden of dental caries.
Can Mean Platelet Volume and Platelet Distribution Width Predict Readmissions Within 24 Hours to Emergency Department?

Objective: In this study; we aimed to investigate the relationship between Mean Platelet Volume (MPV) and Platelet Distribution Width (PDW) values obtained from the initial hemogram of the patients admitted to the emergency department with the re-admission rate to the emergency department within the first 24 hours after discharge. Materials and Methods: This retrospective case-control study was conducted with patients who presented to the emergency service over one-year period. The patients were divided into two groups: The first group consisted of patients who, after presenting to the emergency department and being discharged, were readmitted to the same service within the first 24 hours, the second group comprised of those who were not re-admitted to the emergency department within this period. Statistical analysis was performed between the groups and the ability of these parameters to predict re-admission. A p value of <0.05 was considered statistically significant. Results: The study was carried out with 614 patients: 216 patients in the readmission group and 398 patients in the control group. When the differences between the groups in terms of hemogram parameters were examined, it was determined that MPV and PDW were higher in the readmission group compared to the control group. The multivariate regression analysis revealed that MPV and PDW were significant predictors of readmission cases. According to the ROC curve analysis, MPV had 90.2% sensitivity and 22.5% specificity while for PDW, these values were 20% and 77.0%. Conclusion: It was concluded that MPV and PDW could be guiding parameters in predicting cases of emergency department readmission within 24 hours of discharge.
Spectrum of clinical and imaging findings in patients with serological diagnosis of H1N1 and its correlation with clinical severity

Poster: "ECR 2019 / C-1732 / Spectrum of clinical and imaging findings in patients with serological diagnosis of H1N1 and its correlation with clinical severity" by: "K. Schoen1, N. Horvat2, N. F. C. Guerreiro2, I. de Castro2, K. Giassi2; 1Sao Paulo, Parana/BR, 2Sao Paulo/BR"
Dynamic functional connectivity of migraine brain: a resting-state fMRI study.

Migraine headache is an episodic phenomenon, and patients with episodic migraine have ictal (headache), peri-ictal (premonitory, aura, and postdrome), and interictal (asymptomatic) phases. We aimed to find the functional characteristics of migraine brain regardless of headache phase using dynamic functional connectivity analysis. We prospectively recruited 50 patients with migraine and 50 age- and sex-matched controls. All subjects underwent a resting-state functional MRI. Significant networks were defined in a data-driven fashion from the interictal (>48 hours apart from headache phases) patients and matched controls (interictal dataset) and tested to ictal or peri-ictal patients and controls (ictal/peri-ictal dataset). Both static and dynamic analyses were used for the between-group comparison. A false discovery rate correction was performed. As a result, the static analysis did not reveal a network which was significant in both interictal and ictal/peri-ictal datasets. Dynamic analysis revealed significant between-group differences in seven brain networks in the interictal dataset, among which a frontoparietal network (controls > patients, p=0.0467), two brainstem networks (patients > controls, p=0.0467 and <0.001), and a cerebellar network (controls > patients, p=0.0408 and <0.001 in two states) remained significant in the ictal/peri-ictal dataset. Using these networks, migraine was classified with a sensitivity of 0.70 and specificity of 0.76 in the ictal/peri-ictal dataset. In conclusion, the dynamic connectivity analysis revealed more functional networks related to migraine than the conventional static analysis, suggesting a substantial temporal fluctuation in functional characteristics. Our data also revealed migraine-related networks which show significant difference regardless of headache phases between patients and controls.
Novel approaches to the control of infectious diseases

ii DEDICATION.iv LIST OF ABBREVIATIONS AND SYMBOLS.v ACKNOWLEDGMENTS.x INTRODUCTION: . 1 Chapter 1 : POLYETHER IONOPHORES: BROAD-SPECTRUM AND PROMISING BIOLOGICALLY ACTIVE MOLECULES FOR THE CONTROL OF DRUG-RESISTANT BACTERIA AND PARASITES . 5 Chapter 2 : ANTIMALARIAL, ANTI-MTB AND ANTI-MRSA METABOLITES FROM A MARINE STREPTOMYCES . 65 PART 1 A NEW ANTIMALARIAL POLYETHER FROM A MARINE STREPTOMYCES SP. H668 . 65 PART 2 EPIGENETIC STUDIES YIELDING POTENT ANTI-MYCOBACTERIUM TUBERCULOSIS AND ANTI-MRSA POLYETHERS IN A MARINE STREPTOMYCES SP . 80 Chapter 3 : ANTIFUNGAL AND ANTI-HEPATITIS C VIRUS (HCV) CYCLIC PEROXIDES ISOLATED FROM A JAMAICAN SPONGE OF THE GENUS PLAKINASTRELLA . 96 Chapter 4 : BIOASSAY-GUIDED ISOLATION OF HCV ACTIVE METABOLITES FROM xiv INGA FAGIFOLIA AND DIPLOSTEPHIUM RHODENDROIDES . 154 Chapter 5 : ENVIRONMENTAL TOXICOLOGY – ENCYCLOPEDIA OF SUSTAINABILITY SCIENCE AND TECHNOLOGY "SCIENCE, POLICY, AND RISK MANAGEMENT: THE CASE OF SEAFOOD SAFETY" . 178 Chapter 6 : REDUCING OYSTER-ASSOCIATED BACTERIA LEVELS USING SUPERCRITICAL FLUID CO2 AS AN AGENT OF WARM PASTEURIZATION . 238 BIBLIOGRAPHY. 264 VITA . 293
Inverse Expression of bcl-2 Protein and Fas Antigen in Lymphoblasts in Peripheral Lymph Nodes and Activated Peripheral Blood T and B Lymphocytes

To examine the regulatory mechanism of apoptosis in lymphoid cells, expression of both bcl-2 protein and Fas antigen was investigated in reactive lymph nodes, in resting lymphocytes from peripheral blood (PBLs), and in PBLs stimulated with pokeweed mitogen, interleukin-4 (IL-4) + anti-IgM antibody, IL-2 + anti-CD3 antibody, phytohemagglutinin + phorbol myristate acetate using immunohistochemistry and flow cytometry. Germinal center cells expressed a large amount of Fas antigen, which is associated with the induction of apoptosis in lymphoid cell lines, in contrast to the lack of bcl-2 protein as an apoptosis inhibitor. On the other hand, mantle zone lymphocytes expressed a high level of bcl-2 protein and less Fas antigen. This inverse expression of bcl-2 protein and Fas antigen was also shown in activated T and B lymphocytes from peripheral blood. These lymphoblasts fell into apoptosis dose-dependently in the presence of anti-Fas monoclonal antibody, but resting lymphocytes that expressed both bcl-2 protein and Fas antigen did not undergo apoptosis. These findings suggest that bcl-2 expression prevents the apoptosis of lymphoid cells induced by the Fas antigen-dependent mechanism and that apoptosis of lymphocytes is exquisitely controlled, at least in part, by regulation of the bcl-2 and Fas genes.
Őszi búzafajták növekedésdinamikájának vizsgálata eltérő N-szinteken Hunt-Parsons modellel

Osszefoglalas A termest meghatarozo novekedesdinamika egyreszről genetikailag meghatarozott tulajdonsag, masreszről pedig kornyezeti adottsagoktol fugg. A kornyezeti tenyezők kozul a N-műtragyazasra (0, 80, 160 es 240 kg/ha) adott novekedesi- es produkciobeli reakciokat vizsgaltuk harom elterő tenyeszidejű genotipus (extra korai Mv Toborzo, korai Mv Palotas es kozepkorai Mv Verbunkos) eseteben 2007-ben es 2008-ban. A kiserletet Martonvasaron, erdőmaradvanyos csernozjom talajon allitottuk be. A novekedesanalizishez hetente vettunk mintat, 2007-ben osszesen 24, 2008-ban 21 alkalommal. A szarazanyag es levelterulet dinamikajaval, es az ezekből szamitott novekedesi mutatokkal jellemeztuk a N-műtragyazas, a fajtak, illetve az evjarat hatasat. A novekedesanalizis klasszikus es funkcionalis modszerevel kiszamitottuk a levelterulet index (LAI), a biomassza- es levelterulet tartossag (LAD, BMD), valamint harvest index (HI) mutatokat. Megallapitottuk, hogy a szarazanyag produkcio es a levelterulet az N160, ill. az .
{4-Bromo-2-[3-(dimethyl­amino)propyl­imino­meth­yl]phenolato}dichloro­zinc(II)

The title compound, [ZnCl2(C12H17BrN2O)], is a mononuclear Schiff base zinc(II) complex. The Zn atom is tetra­hedrally coordinated by one phenolate O atom and one imine N atom of the Schiff base, and by two chloride anions. In the crystal structure, mol­ecules are linked through inter­molecular N—H⋯O and C—H⋯Cl inter­actions, forming layers parallel to the bc plane.
Low‐calorie sweeteners and body weight and composition: a meta‐analysis of randomized controlled trials and prospective cohorts (391.1)

Findings from randomized controlled trials (RCTs) and prospective cohorts investigating the relationship between low‐calorie sweeteners (LCS) and body weight and composition have been mixed and use of LCS as part of weight loss efforts remains controversial. The purpose of this study was to systematically review and quantitatively summarize results from RCTs and separately from prospective cohorts. Meta‐analyses evaluated weighted mean change in body weight and composition values between the LCS intervention and placebo groups among the 15 RCTs, and weighted mean correlations for LCS intake and body weight and composition parameters among the 9 prospective cohorts. Compared to placebo, LCS from food, beverages, or supplements significantly reduced body weight (‐0.74 kg, 95% CI: ‐1.10, ‐0.38), fat mass (‐1.18 kg, 95% CI: ‐1.75, ‐0.60), and waist circumference (‐0.93 cm, 95% CI: ‐1.74, ‐0.12), with no effect on BMI. In contrast, the meta‐analysis of cohorts showed that LCS intake was weakly but significantly associated with increased BMI (0.034, 95% CI: 0.009, 0.060), and nonsignificantly associated with increased body weight (0.024, 95% CI: ‐0.010, 0.058) and fat mass (0.035, 95% CI: ‐0.026, 0.096). Overall, available evidence from RCTs indicates that LCS may help reduce body weight, fat mass, and waist circumference, although this conclusion is not supported by results from prospective cohort studies.
Cytoglobin Attenuates Neuroinflammation in Lipopolysaccharide-Activated Primary Preoptic Area Cells via NF-κB Pathway Inhibition

Cytoglobin (Cygb) is a hexacoordinate protein, associated with the transport of oxygen, nitric oxide scavenging, tumor suppression and protection against oxidative stress and inflammation. This protein is expressed in brain areas including the preoptic area (POA) of the anterior hypothalamus, the region responsible for the regulation of body temperature. In this study, we show that Cygb is upregulated in the rat hypothalamus 2.5 h and 5 h after intravenous administration of lipopolysaccharide (LPS). We investigated the effect of treatment with Cygb in POA primary cultures stimulated with LPS for 4 h. The levels of tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6) were measured and the results showed that Cygb reduced the concentrations of both cytokines. We further observed a decrease in immunoreactivity of the inflammatory transcription factor nuclear factor-κB (NF-κB), but not NF-IL6 and STAT3, in the nucleus of Cygb-treated POA cells. These findings suggest that Cygb attenuates the secretion of IL-6 and TNF-α in LPS-stimulated POA primary cultures via inhibition of the NF-κB signaling pathway, indicating that this protein might play an important role in the control of neuroinflammation and fever.