Miracle-dz/UniFAR-FTUs huggingface dataset:
A quasi-experimental text messaging trial to improve adolescent sexual and reproductive health and smoking knowledge in Indonesia.

Background:To evaluate the feasibility and acceptability of a text message intervention to improve young people's knowledge of sexual reproductive health (SRH) and harms related to smoking in Indonesia. Methods: A quasi-experimental short message service (SMS) trial of young people aged 16-24 years receiving twice weekly SMS over a 10-week intervention period. Pre- and post-online demographic and risk behaviour surveys were used to assess changes in knowledge. Among respondents who completed both surveys, we assessed changes in knowledge before and after SMS intervention using paired McNemar's test and differences in mean knowledge score using a paired t-test. Results: In total, 555 eligible young people were enrolled into the SMS intervention; 235 (42%) completed a follow-up survey, of which 198 (84%) were matched to a baseline survey. Median age of participants was 19 years and the majority were female (63%). The mean knowledge score significantly increased between baseline and follow-up surveys for SRH questions [2.7, (95% CI 2.47, 2.94) vs 3.4 (95% CI 2.99, 3.81) (P = <0.01)] and smoking-related questions [3.8 (95% CI 3.66, 3.99) vs 4.1 (95% CI 3.99, 4.28) (P = 0.03)]. A majority of participants reported that the SMS intervention increased their knowledge (95%) and were a useful reminder (95%). Conclusions: An SMS intervention was feasible, acceptable and improved adolescents' SRH knowledge and smoking knowledge in a low- to middle-income setting. SMS interventions targeting young people need to be scaled up, with the potential to explore additional topics around healthy lifestyle, nutrition and physical activity.
Evidence-based conservation education in Mexican communities: Connecting arts and science

Several studies suggest that 63% of primate species are currently threatened due to deforestation, pet-trade, and bushmeat hunting. Successful primate conservation strategies require effective educational programs capable of enhancing critical system-thinking and responsible behavior towards these species. Arts-based conservation education can simultaneously foster cognitive and emotional processes. In this paper, we evaluate an arts-based educational program focused on the conservation of black howler monkeys (Alouatta pigra). Our goals were to determine (1) whether children’s knowledge changed with our educational techniques, (2) if there was a particular educational technique that better improved the children’s learning, and (3) the children’s emotional feedback regarding the whole program. A total of 229 children from communities located in primate-habitat areas, both inside and outside protected areas, participated in the study. Different educational techniques were tested (storytelling, theater and shadow puppets), contrasted with a control group, and evaluated through an analysis of drawings. Our results showed that children’s knowledge increase with each art-based technique, with storytelling being the most effective for children’s learning. Specific drawings indicators also revealed the increase of children’s knowledge and a decrease of misconceptions between pre and post evaluations. Finally, a satisfaction survey about the program showed a high positive feedback. The study highlights the value of designing multidisciplinary projects, where arts-based education program (grounded in scientific information) has shown to be a successful way to communicate animal knowledge and promote conservation.
Satellite‐based estimates reveal widespread forest degradation in the Amazon

Anthropogenic and natural forest disturbance cause ecological damage and carbon emissions. Forest disturbance in the Amazon occurs in the form of deforestation (conversion of forest to non‐forest land covers), degradation from the extraction of forest resources, and destruction from natural events. The crucial role of the Amazon rainforest in the hydrologic cycle has even led to the speculation of a disturbance “tipping point” leading to a collapse of the tropical ecosystem. Here we use time series analysis of Landsat data to map deforestation, degradation, and natural disturbance in the Amazon Ecoregion from 1995 to 2017. The map was used to stratify the study area for selection of sample units that were assigned reference labels based on their land cover and disturbance history. An unbiased statistical estimator was applied to the sample of reference observations to obtain estimates of area and uncertainty at biennial time intervals. We show that degradation and natural disturbance, largely during periods of severe drought, have affected as much of the forest area in the Amazon Ecoregion as deforestation from 1995 to 2017. Consequently, an estimated 17% (1,036,800 ± 24,800 km2, 95% confidence interval) of the original forest area has been disturbed as of 2017. Our results suggest that the area of disturbed forest in the Amazon is 44%–60% more than previously realized, indicating an unaccounted for source of carbon emissions and pervasive damage to forest ecosystems.
Estradiol and/or Ibandronate Therapy Ameliorates A Case Series Describing the Outcomes of Treatment in Co-infected Patients with HIV and Hepatitis C on the United States-Mexico Border

According to the National Health and Nutrition Examination Survey 2007-2010 (NHANES) and the Hispanic Community Health Study/Study of Latinos (HCHS/SOL), the prevalence of Hepatitis C in people of Hispanic descent is 1.5-2%. However, this percentage is estimated to increase as the Hispanic population continues to grow in the United States. Currently there is minimal information on Hepatitis C treatment outcomes in the Hispanic population and even less data in the HIV coinfected, Hispanic population. This study was done to see if there was any differences in the clinical features and treatment outcomes in a population where the predominant race was that of Hispanics. In this small study, we enrolled 36 patients to evaluate the demographics, efficacy of various direct acting anti-Hepatitis C medications in HIV co-infected patients. All the patients were male with over 94% being of Hispanic origin. The average CD4 count at enrollment was 234 cell/cu Original Research Article Heredia and Antony; BJMMR, 15(10): 1-7, 2016; Article no.BJMMR. 26229 2 mm and at the end of treatment was 256 cells/cu mm. A sustained viral response (SVR) or the definition of cure, was noted in all but one of the patients regardless of the medication used, underlying liver stage, or stage of HIV infection.
A phase I dose escalation trial of tremelimumab (CP-675,206) in combination with gemcitabine in chemotherapy-naive patients with metastatic pancreatic cancer.

BACKGROUND Tremelimumab (CP-675,206) is a fully human monoclonal antibody binding to cytotoxic T-lymphocyte-associated antigen 4 (CTLA4) on T cells that stimulates the immune system by blocking the CTLA4-negative regulatory signal. Combination with standard chemotherapy may strengthen antitumor therapy. This is a phase Ib, multisite, open-label, nonrandomized dose escalation trial evaluating the safety, tolerability, and maximum tolerated dose (MTD) of tremelimumab combined with gemcitabine in patients with metastatic pancreatic cancer. PATIENTS AND METHODS Gemcitabine (1000 mg/m2 on days 1, 8, and 15 of each 28-day cycles) was administrated with escalating doses of i.v. tremelimumab (6, 10, or 15 mg/kg) on day 1 of each 84-day cycle for a maximum of 4 cycles. The first 18 patients had an initial 4-week gemcitabine-only lead-in period. Dose-limiting toxicities (DLTs) related to tremelimumab were evaluated during the first 6 weeks after the first dose of tremelimumab. RESULTS From June 2008 to August 2011, 34 patients were enrolled and received at least one dose of tremelimumab. No DLTs related to tremelimumab were observed at any dose, even when the maximum dose established for tremelimumab (15 mg/kg) was used. Most frequent grade 3/4 toxicities were asthenia (11.8%) and nausea (8.8%). Only one patient had a serious drug-related event (diarrhea with dehydration). The median overall survival was 7.4 months (95% confidence interval 5.8-9.4 months). At the end of treatment, two patients achieved partial response. Both patients received tremelimumab 15-mg/kg group (n = 2/19, 10.5%). CONCLUSION Tremelimumab plus gemcitabine demonstrated a safety and tolerability profile, warranting further study in patients with metastatic pancreatic cancer. CLINICALTRIALS. GOV ID NCT00556023.
Risk Factors of Birth Asphyxia Among Neonates Born in Public Hospitals of Tigray, Northern Ethiopia

palsy, ﬁ dif ﬁ with Materials and Methods: Hospital-based unmatched case-control study design was implemented on 390 samples from January to February 2018. Data were collected by interviews using a structured questionnaire and checklist. The collected data were coded and entered using EpiData version 3.1 statistical software and transported to statistical package for social science (SPSS) version 20 software for analysis. Cross-tabulation and odds ratio with 95% con ﬁ dence interval were computed. Bivariate logistic regression and multivariable logistic regression were done. Multicollinearity was checked. Goodness of ﬁ t was checked by the Hosmer – Lemeshow test. Results: A total of 260 controls and 130 cases were enrolled in the study. Multivariable logistic regression showed that Primi-parity [AOR 5.5 (CI: 2.5, 12.3)], pre-eclamcia/preg-nancy-induced hypertension [AOR12.4 (CI: 4.17, 37.15)], post-term pregnancy [AOR 2.73 (CI: 1.00, 7.55)] meconium-stained liquor [AOR 29.2 (CI: 12.0, 71.1)], cord entangled [AOR 5.67 (CI: 1.66,19.3)] and non-vertex presentation [AOR 5.49 (CI: 2.20,13.7)] were found to be risk factors for perinatal birth asphyxia. Conclusion and Recommendations: Intrapartum factors and neonatal factors in the index pregnancy have an association with perinatal birth asphyxia. The research ﬁ nding suggests effective antenatal care follow-up and follow-up of labor progress using partograph after labor initiation.
Educational Change and its Impact on Fertility and Demographic Dividend of Future India

Introduction: A window of opportunity opens up towards the development of a nation as a consequence of rapid demographic transition. In developing societies mortality rates decline followed by a fall in fertility rates, inducing a change in the age structure. As a result of declining population growth there is a bulge in working-age population and shrinking dependent population that can allow for faster rates of economic growth when combined with effective policies and markets.
Implementing a Sustainable Model for Anti-Money Laundering in the United Nations Development Goals

The United Nations Sustainable Development Goals (SDGs), adopted in 2015, are the most relevant global agreements on 17 of the most important issues that are crucial to all countries and their societies. The achievement of all SDGs requires a reduction in the scale of money laundering destabilizing domestic economies. This original research study has shown that the supreme audit institutions’ (SAI) capacity to audit and evaluate anti-money laundering system is limited for a number of reasons including the lack of global SAI standards and guidelines for auditing anti-money laundering systems. The aim of this research was to create a generally accepted approach to auditing anti-money laundering outcomes. To address the research goal, interviews were conducted with 15 representatives of 11 SAIs. In addition, members of the International Organization of Supreme Audit Institutions (INTOSAI) were interviewed and SAI audits of anti-money laundering entities were analysed. A literature review was also carried out. Based on this research study, an original approach both to managing anti-money laundering and auditing such activities was created. This research provides the basis for strengthening risk management that supports an efficient realization of SDGs. The proposed Sustainable Model for Anti-Money Laundering will enhance SAI’s audit capacity and significantly improve parliamentary watchdogs’ investigative functions.
Research on the Types of Pre-Game Expectations in the Athletes of Sports Games

The purpose of the article is to study the types of expectations that have formed within athletes of Sports Games before competitions. The individuals under study are football players, mini-football players, handball players and volleyball players, women-volleyball playersof sports teams participating in tournaments of different difficulty levels (n = 342, ages 14-38). The study presents standardized questionnaire tests, socio-metric type expectometric techniques, content analysis and cluster analysis of k-means. Types of athletes’ pre-game expectations of are an important component of sports, competitive activity in game sports. Understanding types of athletes’ pregame expectations by the coaching staff allows operationalizing the tasks decision of tactical and technical preparation of the team for the game, strategic preparation of the team during the tournament. The aim is to study the types of athletes’ pre-game expectations of sports gamesdirectly before the game. Research Methods: standardized questionnaire tests, expectometry, content analysis, cluster analysis of k-means. The cluster analysis defines four types of athletes’ pre-game expectations: realistic-valuable (RVT), passivemoderate (PMT), unrealistic-pragmatic (UPT) and active-moderate (AMT). The results obtained could be significant for coaching staff, sports directors, anyone involved in coaching and team management, including football, mini-football, handball and volleyball, as well as researchers in the field of psychology and pedagogy of physical education and sports.
Comparative efficacy and safety associated with apixaban and rivaroxaban treatment in morbidly obese versus non-obese patients

Background: Due to limited enrollment of patients with a BMI > 30 or weight > 100 kg in landmark trials for apixaban and rivaroxaban, the International Society of Thrombosis and Hemostasis (ISTH) recommends against the use of direct oral anticoagulants (DOACs) in those with a BMI > 40 or weight > 120 kg. The purpose of this study was to investigate the efficacy and safety of apixaban and rivaroxaban, prescribed in morbidly obese patients compared to nonobese patients.
AVO Interpretation in LMR Space: A Primer

In this paper we present how the more frequently used AVO attributes such as P-impedance, Simpedance, Vp/Vs and Poisson's Ratio petrophysically relate to ρ λ ⋅ and ρ μ ⋅ as well as to each other in the LMR crossplot space. We also present how the magnitude and direction of anomalous movement away from a given non-reservoir reference point in LMR crossplot space can be related to fluid content and AVO class respectively, of the reservoir under scrutiny. Finally we point to possible LMR interpretation pitfalls due to the fact that multiple combinations of mineralogy, fluid and porosity can produce ambiguities in the LMR crossplot space.
The Impact of the Moderating Effect of Psychological Health Status on Nurse Healthcare Management Information System Usage Intention

Nurses play a key role in healthcare but work in a highly stressful and unfriendly environment. Therefore, many medical institutions have adopted nurse healthcare management information systems for nurses to relieve symptoms of mental stress and even improve their psychological health. The key to the success of these systems depends on how nurses intend to use them. In this study, the moderating effect of nurses’ psychological health status on their usage of these systems are discussed. This study used a mail survey method for nurses to obtain 1565 valid samples. The results show that perceived usefulness is insignificant toward the usage intention of nurses with a positive psychological health status, which indicates that this system does not meet the needs of these healthy nurses. Furthermore, perceived ease of use is insignificant toward the usage intention of nurses with a negative psychological health status, which indicates that a negative psychological health status may affect one’s behavior due to impatience. This study raises the serious issue that nurses should maintain their psychological health in order to ensure the quality of care for patients. People in various fields are expected to pay attention to the psychological health status of nurses and create a win–win situation for both patients and nurses.
Examining Paternalistic Leadership Behaviours of Primary School Principals Based on the Teachers Perceptions in Turkey

Bu arastirmanin amaci, ilkokullarda gorevli ogretmenlerin kendi okul mudurlerinin paternalist liderlik davranislarina iliskin algilarini ve bu algilarin ogrenim durumu, mesleki kidem, cinsiyet, medeni durum, sendika uyeligi ve mesleki kidem degiskenlerine gore anlamli fark olusturup olusturmadigini belirlemektir. Betimsel tarama modelinde yapilmis arastirmanin orneklemi, 2016-2017 egitim-ogretim yilinda Mardin merkez Artuklu ilcesi ve bagli 8 ilce merkezindeki kamu ilkokullarindan basit seckisiz yontemle secilen 1059 ogretmenden olusmaktadir. Arastirmanin verileri, “Okul Mudurlerinin Paternalist Liderlik Davranislari Olcegi” kullanilarak elde edilmistir. Verilerin analizi sonucunda ulasilan bazi onemli bulgular sunlardir: Ogretmenlerin ilkokul mudurlerinin paternalist liderlik davranislari ile ilgili algilari “cok katiliyorum” duzeyinde saptanmistir. Ogretmenlerin ilkokul mudurlerinin paternalist liderlik davranislari ile ilgili algilari arasinda; “ogrenim durumu” ve “medeni durum” degiskenlerine gore yardimsever liderlik alt boyutunda ve “cinsiyet” degiskenine gore ise cikarci liderlik alt boyutunda anlamli bir fark saptanmistir. Arastirmanin sonucunda uygulayicilara ve arastirmacilara yonelik oneriler sunulmustur.
Integrating Phenological, Aerobiological and Weather Data to Study the Local and Regional Flowering Dynamics of Four Grapevine Cultivars

Phenological, aerobiological, and weather data are useful tools to study local and regional flowering dynamics in crops with economic importance. The present study focuses on four autochthonous grapevine cultivars, namely, ‘Treixadura’, ‘Godello’, ‘Loureira’, and ‘Albariño’ (Vitis vinifera L.), which belong to the Designation of Origin Ribeiro area (located in northwestern Spain) from 2015–2019. The aims of the work were to (1) compare the airborne pollen concentration in the vineyard collected by two different traps, (2) analyze the influence of the main meteorological variables on cultivar phenology and pollen concentration, and (3) test the contribution of the air masses on pollen concentrations in the vineyard. Phenological development has been assessed twice weekly, according to the Biologische Bundesanstalt, Bundessortenamt und Chemische Industrie (BBCH) scale. Airborne pollen concentrations were monitored by using two traps during stage 6 (flowering), namely, a Hirst volumetric sampler and a Cour passive trap. The bioclimatic conditions affected the duration of flowering, ranging from 11 and 24 days. The highest seasonal pollen integral (SPIn) was registered in 2016 for the Hirst sampler, with 302 pollen, and in 2019 for the Cour trap, with 1,797,765 pollen/m2/day. The main variables affecting pollen concentrations were average temperature during the main pollen season, as well as, temperatures and dew points during the pre-peak period. The relationship between pollen data registered by both traps and the obtained harvest indicate that the Hirst trap may be more suitable for predicting a local production and that the Cour sampler is more appropriate for forecasting regional productions.
Directly, on Constitutive K-Ras Activity Radiation-Induced EGFR Depends Indirectly, but not Stimulated PI3K-AKT Signaling Mediated through Ligand or

Previous results showed an inducible radiation sensitivity selectively observable for K-RAS–mutated cell lines as a function of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor blockade of phosphatidylinositol 3-kinase (PI3K)-AKT signaling. Therefore, the role of K-Ras activity for a direct (i.e., through activation of PI3K by K-Ras) or an indirect stimulation of PI3K-AKT signaling (through K-Ras activity–dependent EGFR ligand production) was investigated by means of small interfering RNA and inhibitor approaches as well as ELISA measurements of EGFR ligand production. K-RASmt tumor cells presented a constitutively activated extracellular signal–regulated kinase-1/2 signaling, resulting in enhanced production and secretion of the EGFR ligand amphiregulin (AREG). Medium supernatants conditioned by K-RASmt tumor cells equally efficiently stimulated EGFR signaling into the PI3K-AKT and mitogen-activated protein kinase pathways. Knocking down K-Ras expression by specific small interfering RNA markedly affected autocrine production of AREG, but not PI3K-AKT signaling, after treatment of K-RAS–mutated or wild-type cells with EGFR ligands or exposure to ionizing radiation. These results indicate that PI3K-mediated activation of AKT in K-RASmt human tumor cells as a function of EGFR ligand or radiation stimulus is independent of a direct function of K-Ras enzyme activity but depends on a K-Ras–mediated enhanced production of EGFR ligands (i.e., most likely AREG) through up-regulated extracellular signal–regulated kinase-1/2 signaling. The data provide new differential insight into the importance of K-RAS mutation in the context of PI3K-AKT–mediated radioresistance of EGFR-overexpressing or EGFRmutated tumors. (Mol Cancer Res 2007;5(8):863–72)