Miracle-dz/UniFAR-FTUs huggingface dataset:
Chiasmatic lesions on conventional magnetic resonance imaging during the first event of optic neuritis in patients with neuromyelitis optica spectrum disorder and myelin oligodendrocyte glycoprotein‐associated disease in a Latin American cohort

Optic neuritis (ON) is often the initial symptom of neuromyelitis optica spectrum disorder (NMOSD) and myelin oligodendrocyte glycoprotein‐associated disease (MOGAD). We aimed to compare the frequency and pattern of chiasmatic lesions in MOGAD‐related ON (MOGAD‐ON) and NMOSD‐related ON (NMOSD‐ON) using conventional brain imaging (magnetic resonance imaging [MRI]) in Latin America (LATAM).
On the use of acoustic signals for detection and location of partial discharges in power transformers

The objective of this work is to assess the efficacy and reliability of a certain technique of acoustic emission measurement for detection and location of partial discharges in power transformers. The possibility of locating a simulated partial discharge was studied in the laboratory. The experimental setup involved an arrangement of increasing complexity, starting with a simple tank filled with insulating oil, up to simulation of an unenergized transformer. It was concluded that, under careful control of experimental parameters, such location is effective. The study was complemented with observations on transformers in the field. In this case, results were less reliable. While the acoustic emission test was not sensitive to intense discharges within the internal winding of a transformer, problems in two tap-switches and one mechanical problem were detected. Considering that the literature reports doubts on the effectiveness of the technique, it was found that measurement of acoustic emission is useful for defects external to the transformer winding. Taking into account its success in locating some kinds of defects, partial discharge measurements by both acoustic and electromagnetic means supplement other usual tests to increase the reliability of the final diagnosis.
Hypotensive episodes revealed by ambulatory blood pressure monitoring in nursing home residents

Susceptibility to hypotension increases at advanced age, particularly in nursing home (NH) residents, a vulnerable population with multiple coexisting risk factors for low blood pressure (BP). Hypotension may be responsible for symptoms such as dizziness, confusion, and drowsiness, which impair autonomy and quality of life. Moreover, hypotension in older people is a frequent cause of syncope and falls, which are more likely to occur in NH residents due to concomitant conditions such as dementia, gait, and balance disorders, which magnify the risk of falls and related complications. Ambulatory blood pressure monitoring (ABPM) is a valuable diagnostic tool to investigate low BP and may be useful to detect hypotension in NH residents. However, ABPM is rarely used in this setting and data regarding ambulatory BP in NH residents are scarce. This study aimed to assess the prevalence of hypotensive episodes in NH residents undergoing ABPM and to analyze the associated clinical features and ambulatory BP profile.
Individuals With SARS-CoV-2 Infection During the First and Second Waves in Catalonia, Spain: Retrospective Observational Study Using Daily Updated Data

Background A description of individuals with SARS-CoV-2 infection comparing the first and second waves could help adapt health services to manage this highly transmissible infection. Objective We aimed to describe the epidemiology of individuals with suspected SARS-CoV-2 infection, and the characteristics of patients with a positive test comparing the first and second waves in Catalonia, Spain. Methods This study had 2 stages. First, we analyzed daily updated data on SARS-CoV-2 infection in individuals from Girona (Catalonia). Second, we compared 2 retrospective cohorts of patients with a positive reverse-transcription polymerase chain reaction or rapid antigen test for SARS-CoV-2. The severity of patients with a positive test was defined by their admission to hospital, admission to intermediate respiratory care, admission to the intensive care unit, or death. The first wave was from March 1, 2020, to June 24, 2020, and the second wave was from June 25, 2020, to December 8, 2020. Results The numbers of tests and cases were lower in the first wave than in the second wave (26,096 tests and 3140 cases in the first wave versus 140,332 tests and 11,800 cases in the second wave), but the percentage of positive results was higher in the first wave than in the second wave (12.0% versus 8.4%). Among individuals with a positive diagnostic test, 818 needed hospitalization in the first wave and 680 in the second; however, the percentage of hospitalized individuals was higher in the first wave than in the second wave (26.1% versus 5.8%). The group that was not admitted to hospital included older people and those with a higher percentage of comorbidities in the first wave, whereas the characteristics of the groups admitted to hospital were more alike. Conclusions Screening systems for SARS-CoV-2 infection were scarce during the first wave, but were more adequate during the second wave, reflecting the usefulness of surveillance systems to detect a high number of asymptomatic infected individuals and their contacts, to help control this pandemic. The characteristics of individuals with SARS-CoV-2 infection in the first and second waves differed substantially; individuals in the first wave were older and had a worse health condition.
Decay characteristics of residual dc voltage for 1000 kV GIS

Volume and surface resistivity are varied by temperature and electric field strength of an insulator. As change of the insulator electric field strength is very small during residual dc voltage measurement, insulator resistivity depends on temperature. So insulator resistivity is estimated by fundamental characteristics of resistivity as a function of temperature. Then the decay time constant of residual dc voltage for l000 kV GIS is calculated by resistivity based on the calculated insulator resistance for the temperature. Finally the measured decay time constant is compared with the calculated one.
Wheat endophytes and their potential role in managing abiotic stress under changing climate

Wheat (Triticum aestivum L.) cultivation differs considerably in respect of soil type, temperature, pH, organic matter, moisture regime, etc. Among these, rising atmospheric temperature due to global warming is most important as it affects grain yield drastically. Studies have shown that for every 1°C rise in temperature above wheat's optimal growing temperature range of 20–25°C, there is a decrease in 2.8 days and 1.5 mg in the grain filling period and kernel weight, respectively, resulting in wheat yield reduction by 4–6 quintal per hectare. Growing demand for food and multidimensional issues of global warming may further push wheat crop to heat stress environments that can substantially affect heading duration, percent grain setting, maturity duration, grain growth rate and ultimately total grain yield. Considerable genetic variation exists in wheat gene pool with respect to various attributes associated with high temperature and stress tolerance; however, only about 15% of the genetic variability could be incorporated into cultivated wheat so far. Thus, alternative strategies have to be explored and implemented for sustainable, more productive and environment friendly agriculture. One of the feasible and environment friendly option is to look at micro‐organisms that reside inside the plant without adversely affecting its growth, known as ‘endophytes’, and these colonize virtually all plant organs such as roots, stems, leaves, flowers and grains. The relationship between plant and endophytes is vital to the plant health, productivity and overall survival under abiotic stress conditions. Thus, it becomes imperative to enlist the endophytes (bacterial and fungal) isolated till date from wheat cultivars, their mechanism of ingression and establishment inside plant organs, genes involved in ingression, the survival advantages they confer to the plant under abiotic stress conditions and the potential benefits of their use in sustainable wheat cultivation.
Phosphatidylserine receptors enhance SARS-CoV-2 infection

Phosphatidylserine (PS) receptors enhance infection of many enveloped viruses through virion-associated PS binding that is termed apoptotic mimicry. Here we show that this broadly shared uptake mechanism is utilized by SARS-CoV-2 in cells that express low surface levels of ACE2. Expression of members of the TIM (TIM-1 and TIM-4) and TAM (AXL) families of PS receptors enhance SARS-CoV-2 binding to cells, facilitate internalization of fluorescently-labeled virions and increase ACE2-dependent infection of SARS-CoV-2; however, PS receptors alone did not mediate infection. We were unable to detect direct interactions of the PS receptor AXL with purified SARS-CoV-2 spike, contrary to a previous report. Instead, our studies indicate that the PS receptors interact with PS on the surface of SARS-CoV-2 virions. In support of this, we demonstrate that: 1) significant quantities of PS are located on the outer leaflet of SARS-CoV-2 virions, 2) PS liposomes, but not phosphatidylcholine liposomes, reduced entry of VSV/Spike pseudovirions and 3) an established mutant of TIM-1 which does not bind to PS is unable to facilitate entry of SARS-CoV-2. As AXL is an abundant PS receptor on a number of airway lines, we evaluated small molecule inhibitors of AXL signaling such as bemcentinib for their ability to inhibit SARS-CoV-2 infection. Bemcentinib robustly inhibited virus infection of Vero E6 cells as well as multiple human lung cell lines that expressed AXL. This inhibition correlated well with inhibitors that block endosomal acidification and cathepsin activity, consistent with AXL-mediated uptake of SARS-CoV-2 into the endosomal compartment. We extended our observations to the related betacoronavirus mouse hepatitis virus (MHV), showing that inhibition or ablation of AXL reduces MHV infection of murine cells. In total, our findings provide evidence that PS receptors facilitate infection of the pandemic coronavirus SARS-CoV-2 and suggest that inhibition of the PS receptor AXL has therapeutic potential against SARS-CoV-2.
Reverberation Degrades Pitch Perception but Not Mandarin Tone and Vowel Recognition of Cochlear Implant Users

Objectives: The primary goal of this study was to investigate the effects of reverberation on Mandarin tone and vowel recognition of cochlear implant (CI) users and normal-hearing (NH) listeners. To understand the performance of Mandarin tone recognition, this study also measured participants’ pitch perception and the availability of temporal envelope cues in reverberation. Design: Fifteen CI users and nine NH listeners, all Mandarin speakers, were asked to recognize Mandarin single-vowels produced in four lexical tones and rank harmonic complex tones in pitch with different reverberation times (RTs) from 0 to 1 second. Virtual acoustic techniques were used to simulate rooms with different degrees of reverberation. Vowel duration and correlation between amplitude envelope and fundamental frequency (F0) contour were analyzed for different tones as a function of the RT. Results: Vowel durations of different tones significantly increased with longer RTs. Amplitude-F0 correlation remained similar for the falling Tone 4 but greatly decreased for the other tones in reverberation. NH listeners had robust pitch-ranking, tone recognition, and vowel recognition performance as the RT increased. Reverberation significantly degraded CI users’ pitch-ranking thresholds but did not significantly affect the overall scores of tone and vowel recognition with CIs. Detailed analyses of tone confusion matrices showed that CI users reduced the flat Tone-1 responses but increased the falling Tone-4 responses in reverberation, possibly due to the falling amplitude envelope of late reflections after the original vowel segment. CI users’ tone recognition scores were not correlated with their pitch-ranking thresholds. Conclusions: NH listeners can reliably recognize Mandarin tones in reverberation using salient pitch cues from spectral and temporal fine structures. However, CI users have poorer pitch perception using F0-related amplitude modulations that are reduced in reverberation. Reverberation distorts speech amplitude envelopes, which affect the distribution of tone responses but not the accuracy of tone recognition with CIs. Recognition of vowels with stationary formant trajectories is not affected by reverberation for both NH listeners and CI users, regardless of the available spectral resolution. Future studies should test how the relatively stable vowel and tone recognition may contribute to sentence recognition in reverberation of Mandarin-speaking CI users.
Challenges of sexually transmitted infections and sexual health among people who inject drugs

Purpose of review This review provides a summary of recently published research on sexually transmitted infections (STI) and related behaviors among people who inject drugs (PWID), covering three major areas: sexual behavior and its role in STI transmission among PWID, multilevel factors associated with STI risk, and strategies addressing sexual health of PWID. This review is timely given the growing priority of combination prevention approaches and integrated care for PWID. Recent findings Modern research improves the understanding that PWID have an increased risk of STI, which varies by gender, setting, type of substance used, and presence of mental disorders. Major socioeconomic and structural factors, specific and nonspecific to PWID, facilitate inequality and sexual risk behavior. Sexual transmission continues to contribute substantially to the spread of bloodborne infections among PWID, accounting for at least 10% of new HIV cases according to epidemiological modeling. Despite the substantial evidence that behavioral interventions can improve sexual health and reduce sex-related risks among PWID, there is a research-practice gap, reflected in the scarcity of implementation studies published recently. Summary Integration of sexual health into prevention programs for PWID is essential to curb transmission of STI, including HIV, among PWID and their sexual partners.
Orthogonal Effects in Seismic Analysis of Skewed Bridges

In seismic analysis of bridges, the designer chooses the direction of the applied earthquake forces arbitrarily. This paper investigates the effects of seismic force direction on the responses of slab-girder skewed bridges in response spectrum and time history linear dynamic analyses. The combination rules for orthogonal earthquake effects, such as the 100/30, 100/40 percentage rules and the SRSS method are also examined. It is concluded that either the SRSS or the 100/40 percentage rule in the skew direction should be used in the response spectrum analysis of skewed bridges. For time history analysis none of the combination rules provide conservative results. In this case, the application of paired acceleration time histories in several angular directions is recommended.
Top athletes handedness in the major racket sports

Previous research showed a higher percentage of left-handed athletes in interactive and fast ball sports than in the general population. The aim of this study was to analyse the patterns of representation of left-handedness in top level co mpetitors of the major racket sports. The hand used to hold the racket by the 100 world best male p layers (selected fro m 2012 rankings ) in tennis (T), table tennis (TT), squash (S) and badminton (B) was recorded. The proportion of left-handers was calculated for each sport and logistic regression analyses were used to evaluate the probability for a player of holding the racket with the left hand given his position in the ranking. TT showed a higher percentage of left-handers (29%) than T (15%), B (16%) and S (14%). Logistic regressions showed that, when going up in the ranking, the probability of using the left-hand to hold the racket tended to increase in TT, B and S, and to decrease in T. The higher proportion of left-handers observed in TT when co mpared to the other sports can be attributed to the fact that, among the analysed sports, TT is a sport in wh ich the opponents s tand with the shortest distance. Furthermore, the technical and tactical co mponents of performance are mo re determinant than physical fitness in TT, and these characteristics, taken together, may favor left-handed players. The very lo w nu mber of left-handers among the very best tennis players may be exp lained by the fact that the disadvantage of a reduced experience against left-handed opponents is nowadays compensated by the player's professionalism. In conclusion, the present study confirmed that left-handed indiv iduals are more represented in racket sports , and especially in TT, when co mpared with the general population. Finally, considering the specific position of each player in the ran king as determinant of left -handedness probability seems to be a promising approach to further analyse left-handedness in the best ranked players of different sports.
Design of a Tennis-Specific Agility Test (TAT) for Monitoring Tennis Players

Abstract Agility is an important ability for tennis players. To be successful in the rallies, players must perform rapid, multidirectional movements in response to the ball and/or the position of the opponent. For a test to be representative in monitoring agility performance, it should capture a combination of the physical and cognitive agility performance. Considering that literature reports no reliable and valid sport-specific agility test for tennis, the aim of this article was to design and evaluate the measurement properties of a Tennis-specific Agility Test (TAT). To evaluate the TAT, test-retest reliability, concurrent validity, and feasibility were assessed. For reproducibility, a two-way mixed ANOVA was performed. Concurrent validity was assessed using Pearson correlations. A total of 69 tennis players participated in this study of whom 16 competed at the international (22 ± 3.7 years, playing level (Dynamic Rating System): . 8 ± . 3), 43 at the national (14 ± 1.4 years, playing level: 4.6 ± 1.4), and 10 at the regional level (15 ± 0.8 years, playing level: 4.9 ± 1.1). Test-retest reliability was found to be moderate with an Intra-Class Correlation coefficient (ICC) of . 74 (p < .01) and a percentual minimal detectable change (%MDC) of 6.2%. Concurrent validity was found to be moderate by comparison with a recognised agility test, the Spider Drill, which measures only the physical component (.70; p < .01), and by comparison with tennis performance for both boys (r = .67; p < .01) and girls (r = .72; p < .01). The feasibility was high with short time for preparation (five to ten minutes) and time per participant (<5 minutes). In conclusion, the TAT shows promising results for assessing sport-specific agility performance in tennis making it likely to be used in the practical setting.
Molecular and docking studies of tetramethoxy hydroxyflavone compound from Artemisia absinthium against carcinogens found in cigarette smoke

Abstract Artemisia absinthium (AA) is an indigenous medicine used for treatment of inflammation of the liver and chronic fever, and is studied as an antimalarial and anticancer agent. The focus of the current investigation was to determine the action and effect of AA on microRNAs (miRNAs) from breast cancer cell lines. Molecular docking is a structure-based drug design process that studies the interaction of small molecule ligands with receptor biomacromolecules to predict binding mechanism and affinity. MiRNA expression profiling was done using microarray technology. Validation of transcripts with regulated expression pattern was done by SYBR-based quantitative real time PCR (qRT-PCR). AutoDock 4.2 programming allots polar hydrogens, bound together total Kollman charges, solvation borders, and fragmental volumes to the protein using auto dock devices in docking research (ADT). As confirmed by SYBR-based RT-PCR, our investigation discovered an upregulation of the miRNA-22 articulation and a downregulation of miRNA-199a*. These findings support and demonstrate the role of AA as a miRNA articulation-influencing factor in human breast cancer progression. AA’s tetramethoxy hydroxyflavone (p7F) molecule was found to be effective in the treatment of cancer. Changes in miRNA expression patterns could be a key pathogenic component in AA’s physiological action on cancer cells.
Comparison of Muscle Activity During 200 m Indoor Curve and Straight Sprinting in Elite Female Sprinters

Abstract The purpose of this study was to assess whether peak surface electromyography (sEMG) amplitude of selected lower limb muscles differed during a) curve and straight sprinting, b) sprinting in inside and outside lanes between lower limbs. Eleven well-trained female sprinters (personal best: 24.1 ± 1.1 s) were included in a randomized within-subject design study, in which participants underwent two experimental conditions: all-out 200 m indoor sprints in the innermost and outermost lane. Peak sEMG amplitude was recorded bilaterally from gastrocnemius medialis, biceps femoris, gluteus maximus, tibialis anterior, and vastus lateralis muscles. Left gastrocnemius medialis peak sEMG amplitude was significantly higher than for the right leg muscle during curve (p = 0.011) and straight sprinting (p < 0.001) when sprinting in the inside lane, and also significantly higher when sprinting in the inside vs. outside lane for both curve and straight sprinting (p = 0.037 and p = 0.027, respectively). Moreover, left biceps femoris peak sEMG amplitude was significantly higher during straight sprinting in the inside vs. outside lane (p = 0.006). Furthermore, right and left vastus lateralis peak sEMG amplitude was significantly higher during curve sprinting in the inside lane (p = 0.001 and p = 0.004, respectively) and for the left leg muscle peak sEMG amplitude was significantly higher during curve compared to straight sprinting in the outside lane (p = 0.024). Results indicate that curve sprinting creates greater demands mainly for the gastrocnemius medialis of the inner than the outer leg, but the degree of these requirements seems to depend on the radius of the curve, thus significant changes were noted during sprinting in the inside lane, but not in the outside lane.
Differences in Nervous Autonomic Control in Response to a Single Session of Exercise in Bodybuilders Using Anabolic Androgenic Steroids

Abstract Considering the role of autonomic nerve activity in blood pressure control, this study aimed to investigate the cardiac autonomic nerve responses after an aerobic exercise session in Anabolic Androgenic Steroids (AAS) users. Twenty men (AAS, n = 9; control group, n = 11) performed an aerobic exercise session (60 min, 70 to 80% of HRmax). Heart rate variability (HRV) was assessed before and during a 60-min post-exercise recovery period. RMSSD (root mean square successive difference of the RR intervals) and the LF/HF ratio (low frequency/high frequency spectra) were also evaluated. The Student's t-test for independent samples was used to compare differences between initial group characteristics. Repeated measures ANOVA was used to compare pre- and post-exercise HRV recovery (p < 0.05). AAS had a lower SDNN (standard deviation of the intervals) (40.8 ± 16.8 vs. 71.6 ± 24.7 ms; p = 0.04, d = 1.4) and a higher LF/HF (3.4 ± 2.1 vs. 1.8 ± 0.9%; p = 0.03, d = 0.9) before exercise. AAS and controls had similar RMSSD (14.0 ± 15.8 vs. 18.9 ± 12.1 ms; p = 0.20) and a LF/HF (2.8 ± 1.6 vs. 2.4 ± 1.2 ms; p = 0.41) immediately post-exercise. The between-groups comparison revealed a higher HF/LF at 30 min (4.3 ± 1.4 vs. 2.5 ± 1.3%; p = 0.008, d = 1.3) and 60 min (5.0 ± 2.2 vs. 2.3 ± 0.8%; p = 0.001, d = 1.6) for the AAS group in the recovery time. This study demonstrated impaired parasympathetic activity at rest and immediately after the exercise session as an adverse effect of AAS usage, but similar behavior regarding the restoration of sympathetic activity.