Miracle-dz/UniFAR-FTUs huggingface dataset:
Eff ects of Gossypin on Fracture Healing in Experimental Femur Fractured Mouse Mechano-Bioregulatory Model

This paper aimed to research the possible eff ects of gossypin in a mechano-bio-regulatory mouse model for bone fracture healing. A total of 28 male Mus musculus BALB/c mice were randomly selected. Four groups were created. Each group consisted of 7 mice. The Control group was called Group 1. Group 2 was a femur fractured group of mice without any medication. Group 3 was the dose group of 5 mg/kg gossypin to mouse with femur fractures. Group 4 was the dose group of 10 mg/kg gossypin to mouse with femur fractures. An open fracture model was created in the right femur of the animals in Groups 2, 3, and 4. The radiological views for all groups were taken on postoperative 1st day, 6th week, and 12th week. All samples were obtained, collected, and prepared for biomechanical features, histopathological examinations, biochemical tests, and PCR tests. In terms of radiological and histological results, gossypin showed a significant diff erence depending on the dose in Group 4 to Group 3. Gossypin had sufficient antioxidant and anti-infl ammatory eff ects in mice with femur fracture in bone healing in Groups 3 and 4. Biomechanical tests showed enough hardness levels and high thresholds in braking forces.
CMAR_A_285598 595..604

Department of Digestive Surgery, Xi Jing Hospital, The Fourth Military Medical University, Xi’an, People’s Republic of China Background: Totally laparoscopic total gastrectomy (TLTG) using the overlap reconstruction method is associated with fewer postoperative complications and fast recovery than laparoscopic-assisted radical total gastrectomy (LATG). However, evidence on the safety and feasibility of TLTG (overlap reconstruction) in patients with advanced Siewert III esophagogastric junction cancer and gastric cancer of the upper and middle third of the stomach is scarce. Methods: This study is a prospective, single-center, single-blind, two-arm randomized controlled trial designed to include 292 patients with advanced Siewert III esophagogastric junction cancer and gastric cancer of the upper and middle third of the stomach who will be randomly assigned to two groups: a TLTG overlap group (n=146) and an LATG group (n=146). The patients’ demographics, pathological characteristics, intraoperative variables, postoperative complications, postoperative recovery variables, 3-year disease-free survival and 3-year overall survival will be collected and analyzed. The primary outcome is the postoperative complications within 30 days after surgery including intra-abdominal hemorrhage, anastomotic leakage, duodenal stump fistula, pancreatic fistula, chyle leakage, abdominal infection, intestinal obstruction, wound complications, pulmonary infection, pleural effusion, pulmonary embolism, cardiovascular and cerebrovascular complications, and deep vein thrombosis. The secondary outcomes are the 3-year disease-free survival and 3-year overall survival. Discussion: This trial will provide high-level evidence for the safety and feasibility of TLTG (overlap reconstruction) compared with LATG in advanced Siewert III esophagogastric junction cancer and the upper and middle third of gastric cancer. Trial Registration: This trial has been registered at the Chinese Clinical Trial Registry: ChiCTR1900025667 (registration date: September 4, 2019).
Effect of biodiesel structural configuration on its ignition quality

Biodiesel is an alternative fuel consisting of alkyl esters of fatty acids from vegetable oils or animal fats. The properties of biodiesel depend on the type of vegetable oil used for the transesterification process. Cetane number is one of the most significant properties to specify the ignition quality of any fuel. The cetane number of biodiesel fuels is considerably influenced by their fatty acid methyl ester composition. The objective of this work is to investigate the influence of fatty acid methyl ester composition on cetane number of biodiesel fuels. In the present work, 15 various biodiesel fuels were prepared and their cetane number was measured experimentally. A wide literature review was made and the measured cetane numbers were compared with the reported values. The dependence of cetane number of biodiesel fuels on their fatty acid ester composition investigated. It was found from the investigation that the unsaturation percentage can significantly affect the cetane number. Copyright © 2010 International Energy and Environment Foundation - All rights reserved.
Flour, dough and bread properties of wheat flour substituted with orange-fleshed sweetpotato flour

ABSTRACT This study investigated some quality attributes of composite flours, dough and bread from wheat flour substituted with orange-fleshed sweetpotato (OFSP) flour at 0–30% levels. Chemical, functional and pasting properties of flours, rheological properties of dough, as well as chemical composition and physical properties of bread were determined. Protein content of composite flours decreased by 25.51–37.37% at 10–30% OFSP flour substitution. Flour composites were higher in ash (2.12–2.33%), crude fibre (3.28–4.34%), water (1.45–2.08 ml/g) and oil (1.45–1.67 ml/g) absorption capacities. Wheat flour (100%) had maximum peak viscosity of 117.71 Rapid Visco Units (RVU) which decreased by 0.71–30.80% with OFSP flour substitution. Dough from composites had higher hydration (82.15–112.10%) and breakdown torque (0.38–0.42 Nm) but lower stability (1.16–2.38 min), protein weakening (0.06–0.37 Nm), starch gelatinization (0.46–0.81 Nm), stability of hot gel (0.04–0.43 Nm) and starch retrogradation (0.46–0.81 Nm). Bread substituted with OFSP flour had higher total carotenoids (1565.50–5179.27 µg/100 g), weight (193.74–198.50 g) and crumb moisture (27.81–27.91%).
Investigation of selenium compounds as targets for 76,77Br production using protons of energies up to 34 MeV

Abstract Selenium compounds of Zn, Sn and Cu were prepared using a conventional sintering method and the phase composition of each compound was investigated using X-ray diffraction. The compounds prepared were tested under variable irradiation and separation conditions for 76,77Br production. The activity of 77Br was measured as a function of proton beam current within the range 2–15 μA and the thermal stability of the irradiated compound was investigated. The results showed that the compounds ZnSe and Cu2Se are thermally more stable in comparison to the SnSe. The effects of several factors, such as temperature, gas flow rate and separation time, were studied to obtain the maximum separation yield of radiobromine by the dry distillation method. The data showed that the compound Cu2Se is the most suitable target for proton irradiation to produce 76,77Br at energies up to 20 MeV. A simplified method was used to prepare also CuSe, which was tested in irradiations with intermediate energy protons of beam currents up to 10 μA. The data of a typical production run using 17 MeV protons and the Cu2Se target are reported.
Prevalence of anti-leptospiral antibodies and frequency distribution of Leptospira serovars in small ruminants in enzootic South Peninsular India

Abstract Background and Aim: For understanding the epidemiology of leptospirosis, the confined abundance of several species of pathogenic leptospires and knowledge on the serovar(s) prevalent in the reservoir and carrier hosts may be a useful indicator of transmission to incidental/accidental hosts in a geographical niche. The present study was carried out to ascertain the frequency distribution of Leptospira serovars and the prevalence of anti-leptospiral antibodies in small ruminants (sheep and goats) in the epidemiological units (villages) in the coastal districts of enzootic regions in South Peninsular India. Materials and Methods: A total of 1167 serum samples (sheep n=299 and goats n=868) from apparently healthy animals, randomly collected from various epidemiological units were tested in microscopic agglutination test (MAT) using 18 reference Leptospira serovars antigens. Results: The overall seroprevalence of 40% (at 95% confidence intervals [CI]: 36.82-42.43) in small ruminants (44% [95% CI: 40.49-52.26] in sheep and 38% [95% CI: 34.96-41.41] in goats) was observed with the predominance of Icterohaemorrhagiae, Javanica, Australis, Hurstbridge, and Pyrogenes serogroup anti-leptospiral antibodies in the studied region. The Chi-squared test revealed that the presence of anti-leptospiral antibodies is significantly not independent (associated) across the administrative division (Chi-square=105.80, p<0.05) as well as for sheep (Chi-square=34.67, p<0.01) and goats (Chi-square=68.78, p<0.01). Among seropositive samples (n=462 reactors), the MAT was positive for more than one serovar in 73% of sheep (95/131) and 53% of goats (177/331), representing an overall 59% cross-reactive prevalence in small ruminants. The determined frequency distribution (varied among small ruminants) of the employed serovars representing major reactive serogroup was Icterohaemorrhagiae (29.87), Javanica (20.78), Australis (20.35), Hurstbridge (16.23), Pyrogenes (15.8), Djasmin (15.58), Bataviae (15.37), Autumnalis (14.5), Canicola (14.5), Hebdomadis (14.07), Shermani (13.64), Panama (13.42), Sejroe (12.77), etc. Conclusion: This study indicates alarmingly high seroprevalence of leptospirosis in small ruminants with existing endemicity in the studied region in South Peninsular India. Further, these prevalent serovars in the administrative division may be of use in the reference panels of antigens in the MAT in both humans and animal disease diagnostic laboratories for effective and timely diagnosis of leptospirosis and to combat the challenges in public health.
The Role of Vitamins in Non-Alcoholic Fatty Liver Disease: A Systematic Review

Non-Alcoholic Fatty Liver Disease (NAFLD) emerged as the most prevalent liver disorder contributing significantly to disease burden worldwide. It manifests as a broad spectrum of hepatic damage with varying severity ranging from less serious steatosis to a more severe Non-Alcoholic Steatohepatitis (NASH), with or without fibrosis, cirrhosis, and hepatocellular carcinoma. Vitamins, on the other hand, are micronutrients that are vital for healthy well-being. Some studies have linked liver diseases with hypovitaminosis; however, there are still some gaps about the basis of their correlation. Hence, this systematic review aims to discuss the role of vitamins in the pathogenesis of NAFLD and explore their hepatoprotective potential that may benefit clinicians in managing this condition. This systematic review searched for studies indexed in the PubMed, PubMed Central, Medline, Google Scholar, and ScienceDirect databases. Inclusion and exclusion criteria were applied, duplicates were removed, and meticulous screening of articles was done systematically. Out of 729 unique studies generated using the search strategy, 17 were finally included after thorough review and quality appraisal. NAFLD is not simply an outcome of insulin resistance and metabolic derangements; instead, it is a disease with complex underlying pathogenesis. Moreover, vitamin deficiency has been associated with NAFLD development and increased susceptibility to more severe liver damage. Derangement in vitamins correlates to the lipotoxic hepatic environment, altered immune system, unwarranted inflammation, oxidative stress, gene mutations, epigenetic modification, and gut dysbiosis seen in NAFLD. As they influence several pathophysiologic processes in the liver, vitamins A, B3, B6, B9, B12, C, D, and E are promising potential options that can impact NAFLD management. However, more well-designed studies conducted in the human population are still necessary to establish their efficacy and safety as therapeutic agents.
Optimal Macroprudential Policy and Asset Price Bubbles, WP/21/184, August 2019

We study the interplay between firms’ indebtedness and stock market bubbles. A bubble relaxes borrowing constraints and increases borrowing capacity of credit-constrained firms. Yet a deflating bubble amplifies downturns when constraints start binding. We show analytically and quantitatively that optimal macroprudential policy should respond to bubbles in a non-monotonic way, which depends on the underlying level of indebtedness. If the level of debt is moderate, policy should accommodate the bubble to reduce the incidence of a binding borrowing constraint. If debt is elevated, policy should lean against the bubble more aggressively to mitigate the externalities when constraints bind. JEL Classification: E2, E44, G1
Evaluation of promising commercial sugarcane genotypes for stability by AMMI analysis

The choice and recommendation of a variety for commercial cultivation are influenced by genotype x environment interaction (GEI)). The complication of genotype by environment interaction (GEI) is that usually involves layout of trials in various seasons, making it difficult to identify the genotype adapted to different environments. Twenty sugarcane clones and four standard checks were evaluated under three environments within the tropical climate. Additive Main Effects and Multiplicative Interaction (AMMI) model was applied to assess the extent of genotype x environment (GE) interaction and also the stability of sugarcane clones across the environments. The significant difference was observed by AMMI analysis among the tested clones and environments. The sum of the first two principal components conferred to 63.6 per cent of the total of G x E interaction. In the present study, the genotypes G24 (Co 88025), G23 (CoV 94101) and G20 (Co 16001) recorded in high mean yield and higher Principal Component Analysis (PCA) scores; hence, these materials specifically suited to the favorable locations. Since the genotypes Co 15021(G19), Co 0240 (G3), and Co 13001(G7) were near the center point of the axes and hence were influenced by the environment. These clones recorded higher cane yield and stability and suitable for cultivation in different environments. The utilization of the AMMI model made it easy for the visual comparison and identification of exceedingly superior genotypes for every set of environments.
Nurturing Employee Engagement through the Application of Socialization Tactics

The research was conducted to determine how different onboarding programs, otherwise termed as socialization tactics affects the level of employee engagement among new hires. In this study, faculty members and staff from the different colleges in Oman were chosen as the respondents. The study revealed, among other things that, the typology of socialization tactics has varied effects on the level of employee engagement and that there is a statistically significant relationship between socialization tactics and employee engagement. Further studies need to be conducted applying different statistical techniques to further demystify the gray areas that were revealed in the study. This may be done through the application of structural equation modelling or any other techniques that can possibly eliminate observed variables that taints the results of the study.
Genetic variability and association studies in segregating generation of red sorghum (Sorghum bicolor (L.) Moench) population

Sorghum is a universal crop grown for its diversified end uses. A total of 250 plants of F 2 generation were evaluated for nine quantitative characters of cross made between Paiyur 2 and Kottathur local 5. The minimum difference was observed between the phenotypic coefficient of variation and genotypic coefficient of variation for all the traits which reveals that the effect of environment was minimum on the expression of the character. High PCV was observed for plant height (20.36%), test weight (23.59%), and single plant yield (44.52%). Low PCV was observed for days to fifty percent flowering (9.80%), days to maturity (6.54%) and number of leaves (7.14%). High heritability accompanied with genetic advance was observed for plant height (h2=99.03%; GAPM=41.55%), leaf length (h2=97.87%; GAPM=23.70%), stem diameter (h2=94.49%; GAPM=27.36%), test weight (h2=99.03%; GAPM=48.13%), and single plant yield (h2=99.57%; GAPM=91.33%) and it indicates that the characters are under the additive gene action and suitable for the selection process. Plant height (0.6115) recorded positive significant correlation with single plant yield and hence selection towards the plant height directly improves the yield. Plant height (0.6132) and test weight (0.297) showed positive direct effect on single plant yield which indicates that the selection towards these characters will improve the yield.
Commentary on long-term macular vascular density measured by OCT-A in children with retinopathy of prematurity

Laser photocoagulation is one of the therapeutical options for the treatment of Retinopathy of Prematurity (ROP) [1-3]. Although generally considered a safe procedure, it may be associated with an increased risk of cataract development and myopia [2,4,5]. Recent studies with optical coherence tomography angiography (OCT-A) in former preterm children with history of ROP have additionally demonstrated changes in macular morphologic and vascular parameters [6-11]. However, since there are few publications on this topic, we still do not know the long-term impact of laser treatment on macular parameters and vasculature in addition to the effects of the disease [6-11]. Our study aimed to assess long-term superficial vascular density measured by OCT-A in former preterm children with history of ROP with and without need of laser treatment.
The influence of leading-edge tubercles on the hydrodynamic performance and propeller wake flow development of a ducted propeller

This study implements leading-edge (LE) tubercles on a benchmark 19A accelerating duct to investigate the impact on the hydrodynamic performance and propeller wake flow development at multiple operating conditions. The study was conducted using Computational Fluid Dynamics (CFD) where the sliding mesh technique was used to describe the propeller rotation and the hydrodynamic flow-field was solved using Improved Delayed Detached Eddy Simulations (IDDES). In summary, it was found that LE tubercles can enhance the thrust of the duct by a maximum of 7.15% and disrupt the coherent vortex structure of the benchmark ducted propeller which will likely influence the noise signature of the propulsor.
Effectiveness of Education Program on Nurse-Midwife’s Knowledge Regarding Immediate Newborn Care in Delivery Rooms at Maternity Hospitals in Baghdad City/Iraq

Immediate newborn care is the care given to newborns in the transitional period (immediately after birth) which crucial to their survival. Nurses- midwives require adequate knowledge and skills to provide immediate newborn care. The study was aimed at determining the effectiveness of education program on nurses- midwives’ knowledge before and after the implementation of an educational program regarding immediate newborn care in delivery room among study sample. Quasi-experimental study was conducted from 1 st October 2019 to 20th January 2021 at three maternity teaching hospitals in Baghdad city/Al-Russafa Health Directorate: Al-Elwiya Maternity Teaching hospital, Al- Maternity and Pediatric Hospital, Al- Za’faraniyah General Hospital. Non-probability (convenient sample) used to collect the data from (40) participant (nurse-midwife) who work in delivery room that considered as study sample. The results of study indicated that nurses– midwives’ knowledge assessment before the implementation of an educational program for study sample was moderate related to immediate newborn care in delivery room. There were high significant differences in participants’ knowledge at pretest and posttest before and after the implementation of education program for study sample. Socio- demographic and professional variable were no significant effect on their knowledge. The study findings showed that program had been an effective method of increasing the nurses- midwives’ knowledge about immediate newborn care in delivery room.
Effect of modification extent of montmorillonite on the performance of starch nanocomposite films

The mechanism of the influence of organically modified montmorillonites (OMts) with different modification extents on starch/OMt nanocomposites was investigated. The nanostructures of OMts and their dispersion in starch films were analyzed using X-ray diffraction (XRD) and transmission electron microscopy (TEM), respectively. The modifier content in the OMts increased with an increase in the added amount and molecular weight of the modifiers. The highest d-spacing of 3.71 nm was achieved for the OMt modified with 30% dioctadecyl dimethyl ammonium chloride (DDAC). Intercalated nanostructures were formed between starch and the OMts modified with DDAC, whereas exfoliated nanostructures were formed between starch and the OMts modified with octadecyltrimethyl ammonium chloride (OAC) and octadecyl dimethyl benzyl ammonium chloride (ODBAC). The films with the OMt modified with 50% DDAC exhibited the highest tensile strength of 6.22 MPa. The water vapor permeability (WVP) of the film with the OMt modified with 30% DDAC exhibited a minimum value of 1.63 × 10−10 g · m/m2 · s · Pa. The amount and types of the modifiers in the OMts significantly influenced the structure and properties of the starch/clay nanocomposites. For a given polymer, the modification extent of Mt should be optimized to achieve high-performance nanocomposites.
Characterization of the Neuroprotective Function of the TGF-β Signaling Pathway in the Retina

The aim of this work was to demonstrate the neuroprotective role of TGF-β signaling on photoreceptors in the adult retina and to investigate the molecular mechanisms, mediating this effect. The assessment of this notion included the generation of transgenic mice, bearing a TβRII deficiency in different subpopulations of retinal cells. The deletion of TGF-β signaling in retinal neurons and Muller cells, accompanied by a reduced phosphorylation of retinal SMAD3, led to an increased susceptibility to light-induced degeneration, resulting in a thinner outer nuclear layer (ONL), an attenuation of photoreceptors’ responses in the frame of functional analyses and elevated rate of TUNEL-positive apoptotic cells in the Tgfbr2∆oc mouse model. The downregulation of the pathway in rod photoreceptors (Tgfbr2∆rod) did not yield a comparable outcome, a fact, which implicates that other cells than rod photoreceptors are most likely responsible for the observed neuroprotective effect. To the best of our knowledge, the Muller cells are very likely candidates. To identify the molecular machinery, which might convey the neuroprotective properties of the TGF-β signaling pathway, real-time RT-PCR analyses for neuroprotective factors and Western blot analysis for AKT/pAKT were performed. We found that following light exposure, the deletion of TβRII in the Tgfbr2∆oc model resulted in a diminished phosphorylation of AKT, a serine/threonine-specific protein kinase, bound and activated by PI3K. Thus, the neuroprotective effect, downstream of TGF-β, is most likely regulated through the activation of the PI3K/pAKT signaling cascade.
Physico-Chemical Analysis of Drinking Water Samples of Different Places in Kadegaon Tahsil, Maharashtra (India)

Drinking water has great effects on human health. This research throws light on to the physico-chemical analysis of drinking water in Kadegaon Tahsil, Maharashtra (India). In present study two different scenarios were compared: Well water and bore well water. The parameters such as water temperature, total dissolved solid, hardness, pH, alkalinity, dissolved oxygen, chemical oxygen demand, biological oxygen demand, conductivity and chloride, were analyzed from period of 1 Aug 2016–10 Oct 2016. Our results demonstrated that drinking water collected from different places of Kadegaon Tahsil was not found to be suitable for human health