Miracle-dz/UniFAR-FTUs huggingface dataset:
Advancement Of A Valid Model Of Chronic PTSD And Repetitive mTBI: Implications For Pathophysiology And Drug Discovery

Post-traumatic stress disorder (PTSD) is increasingly being recognized as a health and economic burden. PTSD can develop after witnessing or experiencing severe or life threatening trauma and is associated with a number of devastating symptoms that result in decreased quality of life. In addition, PTSD patients have difficulties integrating into society and are at greater risk for other neuropsychiatric disorders, including suicide and substance abuse. The prevalence of PTSD ranges from 8% to 12 % in the general population with a noticeably higher incidences in the US military (20 % -34 %). Current treatment strategies for PTSD are limited and provide only symptomatic relief. Furthermore, many military-related PTSD cases are complicated with the presence of other comorbidities such as mild traumatic brain injury (mTBI). Comorbid PTSD and mTBI pose particular challenges clinically; the similar symptomatic profiles and unclear presentations in the comorbid condition make it difficult to both diagnose and treat. As both military and civilian populations are increasingly exposed to traumatic stress and mTBI, establishing criteria that facilitate the discrimination between these conditions and developing new effective treatments should be a top priority. Animal models are an appropriate platform for conducting such studies. In Chapter 1, the epidemiology, diagnosis and pathophysiology of PTSD and TBI are reviewed. In addition, a quick summary of preclinical animal models of the two conditions is presented. The thesis then focuses on the establishment and validation of a chronic mouse model of PTSD (Chapter 2) and PTSD with comorbid repetitive mild TBI (Chapters 3). Chapter 4 investigates the key molecular mechanisms implicated in PTSD pathophysiology in a mouse model. Finally, the outcomes of a pilot treatment study are presented in Chapter 5.
Inter-relationship between Physico-chemical Variables and Litter Production in Mangroves of Indian Sundarbans

Litter production in mangrove has immense ecological importance, as it sustains both the planktonic and detritus food webs in the aquatic phase and intertidal mudflats, respectively. The present study was undertaken in the western and central sectors of Indian Sundarbans that are different in terms of physico-chemical variables (particularly salinity). Litter production was higher in the western sector owing to higher diversity of mangrove species in the selected plots. High salinity and wind action also accelerated the process of litter fall (both leaf litter and miscellaneous litter), and hence, the peak values of total litter, leaf litter and miscellaneous litter fall (except Sagar Island) was observed in premonsoon season, in both the western and central sectors of the study area.
Factors Affecting the Prediction of Saleable Meat Yield in Lamb Carcasses Using Electronic Probe Technology

Factors Affecting the Prediction of Saleable Meat Yield in Lamb Carcasses Using Electronic Probe Technology Curtis Mikel Advisor: University of Guelph, 2014 Professor I.B. Mandell This thesis is an investigation of the use of electronic probe technology (Viewtrak PG207 optical probe) for predicting saleable meat yield (SMY) in lamb carcasses. 370 lambs were used in this study to compare probe versus carcass measures of backfat and longissimus muscle depth. Pearson correlation coefficients were determined to test probe accuracy versus actual carcass measures. Multiple regression analysis evaluated relationships among probe and carcass measures to SMY. ANOVA was used to determine significant predictors of saleable meat yield and develop prediction equations. Coefficients of determination (R) for models with probe measurements on the hot carcass ranged from 0.014 to 0.284 (P ≤ 0.86) and 0.120 to 0.316 (P ≤ 0.50) on the chilled carcass. In this study, Viewtrak PG-207 optical probe measurements could not be used alone to accurately predict SMY in lamb carcasses.
Protective and/or Therapeutic Effects of Curcumin Nanoparticles on Monosodium Glutamate Induced Cardiotoxicity in Male Albino Rats

The flavor enhancer monosodium glutamate (MSG), which is produced from glutamic acid, is frequently used as a food enhancer in processed foods. The usage of MSG as a food additive is still debated. Moreover, curcumin, the main active compound of turmeric extract, has antioxidant, anti-mutagenic, and antimicrobial properties; additionally, it has several pharmacological activities against many chronic diseases, and its conjugation with nanomaterials increases its efficacy. This work studied the protective and therapeutic impacts of curcumin nanoparticles (CUR-NPS) on cardiotoxicity persuaded by MSG. In this work, 40 adult male albino rats were used and divided into five groups (8 rats per group): control, CUR-NPS, MSG, therapeutic, and protective groups. At the end of the treatment period, the rats were sacrificed, and then the biochemical, molecular, and histopathological investigations were performed. The outcomes demonstrated that the curcumin nanoparticles reduced the levels of malondialdehyde (MDA), lactate dehydrogenase (LDH), creatine kinase-MB (CK-MB), endothelin-1 (End-1), heart fatty acid binding proteins (HFABP), calcium (Ca +2 ), and DNA damage while elevating the levels of both nitric oxide (NO) and total antioxidant capacity (TAC). Moreover, CUR-NPS improved the histopathological changes in heart tissue.
Influence of irrigation and nitrogen levels on growth, yield attributes and yield of maize (Zea mays)

A field experiment was conducted at the Tamil Nadu Agricultural University, Coimbatore, Tamil Nadu, during the winter (rabi) seasons of 2013 and 2014, to investigate the effect of nitrogen and water-management practices on potential yield of maize. The crop was subjected to 2 irrigation levels (cumulative pan evaporation: 0.80 and 0.50) and 5 staggered nitrogen levels (0, 50, 75, 100 and 125% of recommended dose of nitrogen (RDN). The ex- periment was laid out in a factorial randomized block design with 10 treatments and replicated thrice. Irrigation at IW : CPE ratio of 0.80 along with 250 kg N/ha (100% RDN) favourably increased the higher growth parameters, nutrient uptake, yield attributes and higher grain yield (7.31 t/ha) of maize. The crop did not respond significantly to further increase in nitrogen level up to 125% RDN (312 kg N/ha) over the 100% of recommended dose of nitro- gen (250 kg N/ha). Better correlation coefficient of r2 = > 0.95 was obtained with significant at P = 0.01 levels be- tween growth parameters and yield attributes of maize. The same set of treatment resulted in higher net returns (64.3 103 /ha) and benefit: cost ratio (2.89) than others.
Profile of Students' Creative Thinking Skill on Colloid Materials Through Chemistry Flipbooks

This research aims to describe creative thinking skills of 19 XI grade students of Darul Quran Mojokerto Senior High School. This study used explanatory sequential mix methods quantitative and qualitative to provide of students’ abilities. Analysis of creative thinking skills is carried out through the results of creative thinking tests before and after using chemistry flipbooks and analysis of the results of making colloidal products. The instruments used was creative thinking pretest-posttest question sheet and colloid product assessment sheet accompanied by a scoring rubric that has been validated and declared valid for being used as a test to measure creative thinking skills. The average percentage results for each indicator are 95.62% for fluency, 77.20% for flexibility, 73.25% for originality and 87.71% for elaboration. The percentage for creative thinking level is 79% for very creative and 21% for creative. The results of this study are expected to be used as a basis for designing learning that can train creative thinking in other subjects.
Assessment for Nurses’ Practices Regarding Pre and Postoperative Care for Patients with Total Knee Arthroplasty

: Background: Total knee arthroplasty (TKA) is one of the most clinically successful and cost-effective medical procedures developed during the mid of last century, and usually used to treat chronic refractory knee pain and loss of movement because of various underlying knee problems, Purpose: to assess nurses' practices related to pre and postoperative care of patient with total knee arthroplasty, Design: A descriptive research design was used in the study. Setting: The present study was carried out at Orthopedic Departments affiliated to the Suez Canal University Hospitals, Sample: All available staff nurses (80 nurses) were included in the study, Instruments: Nurses‟ Practices Observational Checklist specifically designed for the care of patients undergoing total knee arthroplasty, Results: The findings of the study indicated that a significant proportion, specifically 73.8% of the nurses, demonstrated an incompetent level of total practices concerning the care of patients undergoing TKA. , Conclusion: Based on the results of the current study, the majority of studied nurses had an incompetent level of practices regarding pre and postoperative care of patient with TKA, This outcome raises concerns about the adequacy of nursing practices in the pre and postoperative care of TKA patients within the studied setting, As an incompetent practices could potentially impact patient outcomes, recovery, and overall satisfaction with the healthcare provided. Recommendations: Educational programs and educational guidelines about standardized protocol of pre and postoperative nursing care for patients with total knee arthroplasty should be prepared and conducted. Further investigation and intervention may be necessary to address the identified gaps in nursing practices, potentially through targeted training programs, continuing education, or the implementation of evidence-based guidelines. Improving the competency of nursing practices in TKA care is crucial to ensuring the optimal well-being and recovery of patients undergoing this procedure, ultimately contributing to the continued success of TKA as a medical intervention.
Assessment of Knowledge and Hygienic Practices Regarding Menstruation for Visually Impaired Adolescent Girls

Background: Menstruation is part of the female reproductive cycle starts when girls become sexually mature at the time of puberty. A visually challenged female faces daily extra challenges for bearing their everyday skills including menstruation hygiene management. Hygienic practices during menstruation are very important as poor menstruation affects the health by increasing vulnerability to infections. Aim: The study was aimed to assess knowledge and hygienic practices regarding menstruation for visually impaired adolescent girls. Subjects and method: Research design: A descriptive research design was used. Setting: The study was carried out in El-Nor and El-Aml schools in Port-Said city & Damietta city. , which included two schools one school at each city. Sample: Purposive sampling included 50 visually impaired menstruated adolescent girls (27) visually impaired girl at Port-Said City and (23) visually impaired girl at Damietta city. Tools of data collection: first, Structured Interviewing Questionnaire, second, Health practices during menstruation, and third, Girls behaviors and restrictions during menstruation. Results: More than three quarters of the studied visually impaired adolescent girls had poor level of total knowledge regarding menstruation and the majority of them had poor level of health practices during menstruation. Conclusion: There were lack of visually impaired adolescent girls’ knowledge and practices regarding menstruation. Recommendations: Audio educational sessions should be applied to raise awareness and improve health practices of visually impaired adolescent girls regarding menstruation.
The Relationship between Ambidextrous Leadership Behavior and Career Competencies among Nurses

Background: Fostering creativity and adaptation in a healthcare setting is linked to ambidextrous leadership. Educators who support inquiry can assist nurses in acquiring the skills necessary to accept change, integrate new technology, and apply creative methods to patient care. The aim of the study: To identify the relationship between ambidextrous leadership behavior and career competencies among nurses. Subject and method: A descriptive correlational study design that had been used. Setting: Minia General Hospital served as the study's site. Subject : The current study's convenience sample consisted of all 331 staff nurses at Minia General Hospital. Tools of data collection: 1 st tool: Demographic data sheet, 2 nd tool: Ambidextrous leadership behavior scale, and 3 rd tool: Nurse Career Competence Questionnaire. Results: (58.3) percent of Minia general hospital nurses exhibited "moderate" responses toward ambidextrous leadership behavior. In addition, (57.7) percent of nurses exhibited "moderate" responses toward career competencies . Conclusion: There was a positive correlation between ambidextrous leadership behavior and career competencies. Recommendations: Programs for developing leaders that concentrate on ambidextrous leadership should be supported by healthcare organizations.
Effect of irrigation schedule, residue incorporation and nutrient management on system productivity and profitability of soybean (Glycine max)wheat (Triticum aestivum) cropping system in Vertisols of Rajasthan

A 3-year field experiment was carried out at Kota, Rajasthan during 201516 to 201718, to study the effect of irrigation schedule, residue incorporation and nutrient management on system productivity and profitability of soy- bean [Glycine max (L.) Merr. ]wheat (Triticum aestivum L.) cropping system in Vertisols of Rajasthan. The treat- ments consisted of 24 combinations of 2 irrigation schedules in soybean, viz. 1 irrigation at flowering stage and 2 irrigations at flowering and other pod-development stages -in main plots; 4 wheat residue-management practices, viz. sowing of soybean after wheat-residue burning, wheat-residue incorporation without irrigation, residue incor- poration with irrigation and application of urea @ 25 kg/ha and residue incorporation with irrigation and application of urea @ 25 kg/ha + cellulolytic microbes @ 2.0 kg/ha in subplots; and 3 nutrient-management practices, viz. 75% recommended dose of fertilizers (RDF), 100% RDF (20 kg N, 40 kg P O , 40 kg K O/ha) and 125% RDF in sub- 2 5 2 subplots. The experiment was laid out in a split split-plot design with 3 replications. Wheat crop was sown every year with the adoption of recommended package of practices. Pooled data of 3 years revealed that 2 irrigations at flowering and other at pod development stages-in soybean crop significantly increased dry-matter production, unit- area efficiency, branches/plant, pods/plant, seeds/pod, seed index, seed and straw yields and net returns of soy- bean, grain yield of wheat, soybean-equivalent yield (SEY), profitability, production- and economic-efficiency of system, available N, P and K status of soil after harvesting of wheat and soybean as compared to 1 irrigation at flowering stage. However, available K status of soil after harvesting of soybean was found non-significant in rela- tion to irrigation. Wheat-residue incorporation with irrigation and application of urea @ 25 kg/ha + cellulolytic mi- crobes @ 2.0 kg/ha resulted in the highest growth and yield attributes, seed and straw yields and net returns of soybean, water-use efficiency (WUE), water productivity (WP), soybean-equivalent yield (4.51 t/ha), system profit- ability ( 96,520/ha), production (12.35 kg/ha/day) and economic (264 /ha/day) efficiency of system, organic car- bon, bulk density of soil after harvesting of soybean and N, P and K status of soil after harvesting of both soybean as well as wheat over wheat-residue burning. Application of 125% RDF resulted in the maximum growth and yield attributes, seed (1.51 t/ha) and straw (2.17 t/ha) yield, net returns ( 25,700), benefit: cost ratio (1.09) of soybean and SEY (4.44 t/ha), system profitability ( 95,740/ha), production (12.15 kg/ha/day) and economic efficiency (262 /ha/day), bulk density (1.42 Mg/m3), N (282, 288 kg/ha) P O (24.6,25.9 kg/ha) and K O (293, 299 kg/ha) of 2 5 2 soil after harvesting of wheat and soybean respectively.
Minimizing Mineral Nitrogen Fertilizers Losses to Mango Trees Using Urea-formaldehyde Slow Release Fertilizer and Nitrobein Biofertilizer Under New Valley Conditions

A significant amount of chemical fertilizers are lost due to their widespread use in regions with high temperatures, which also pollute the ecosystem and lower soil fertility. Consequently, using highly nutritious, environmentally friendly fertilizers that are also compatible with the soil and environment is imperative. The application of fertilizers that give macro-and micronutrients to fruit trees is one of the key components of biofertilizer and nitrogen slow release fertilizers in agriculture. A two-year trial was conducted during the 2021 and 2022 seasons in Keitt mango trees orchard about five years old grown in sandy soil under a drip irrigation system from a well at a private orchard, in New Valley Governorate, Egypt. The main objective of this work is to study the effect of three rates of Nitrobein biofertilizer (0.0, 200, and 400 g/tree) and four rates of urea-formaldehyde fertilizer (0.0, 500, 750, and 1000 g/tree) on vegetative growth parameters, yield and fruit quality of Keitt mango trees. Briefly, Nitrobein and urea-formaldehyde treatments enhanced all studied growth, yield, and fruit quality traits. Nitrobein biofertilizer at 400 g/tree combined with urea-formaldehyde fertilizer at 1000 g/tree treatment proved to be the most efficient treatment in this respect.
Histopathologic Changes and Molecular Characterization of Fascioliasis (a Zoonotic Disease) among Slaughtered Livestock in Erbil and Halabja Abattoirs, Kurdistan Region-Iraq

Fascioliasis is a zoonotic disease, caused by the parasites Fasciola (F.) hepatica and F. gigantica, which poses a great threat to the ruminants in addition to humans in many countries, including Iraq. Hence, the study of this parasite and its deleterious impacts on host, morphologically, histopathologically, epidemiologically, and molecularly, is so important. Hence, the current study was designed to investigate this fluke of livestock in Erbil and Halabja slaughterhouses from August to October 2022. To meet the prerequisites of the study, 33 flukes were collected from the sheep and cattle at study sites. The samples were transported to the Zoology Research Laboratory, Salahaddin University-Erbil, Iraq. Some of them were used for morphological identification, and others were preserved in 96% ethanol and stored at -20°C. Subsequently, DNA was extracted. Conversely, pieces of the infested liver were fixed in 99% ethanol and 10% formalin before histopathologic examination. The parasite species were identified using traditional Polymerase Chain Reaction (PCR), and sequencing methods. Macroscopically, hepatomegaly was the main finding of the infestation. Among livestock, cattle exhibited the highest rate of morbidity, followed by goats and sheep. The amplified DNA region was 98–99%, matched to F. hepatica and F. gigantica sequences. It was also established that 28S rDNA sequencing combined with morphologic characteristics of Fasciola species can be applied as a salient indicator in the identification of flukes. The current study is reckoned as a comprehensive investigation regarding fascioliasis, because it covered the parasite epidemiology, morphology, and molecular identification, despite of histopathologic examination.
Continuous versus Intermittent Use of Meropenem in Septic Critically Ill Patients: A Randomized Controlled Trail

Background: Meropenem is commonly used in the treatment of critically ill patients with sepsis. However, the optimal dosing regimen remains a subject of debate. This study aimed to compare the pharmacokinetic, clinical, and bacteriological efficacies of continuous infusion of meropenem versus traditional intermittent administration in critically ill patients with sepsis, and to evaluate the safety of both dosing regimens. Methods: This prospective randomized controlled trial was conducted on critically ill patients diagnosed with sepsis and admitted to the ICU. Patients were randomly assigned to either the continuous infusion group (n=30) or the intermittent intravenous group (n=30). Clinical parameters, laboratory data, and clinical outcomes were recorded. Microbiological outcomes, including microbiological eradication and superinfection, were assessed. Pharmacokinetic analysis was performed to evaluate drug concentrations. Results : The superinfection rate (requiring other antibiotics) was lower in the continuous group (3.3%) compared to 16.7% in intermittent group. The mean total fluid infusion in the first 24hr was 4190 ml in the continuous group compared to 4336 ml in the intermittent group. The mean length of ICU stay was 10.10 ± 6.12 days in the continuous group compared to 11.60 ± 5.55 days in the intermittent group. A significantly lower mean duration of meropenem treatment (9.93 days) was associated with continuous group compared to 11.53 days in intermittent group. Mortality rate was lower in the continuous group (26.7%) compared to intermittent group (40%). Conclusion: Continuous infusion of meropenem demonstrated superior clinical and bacteriological outcomes in critically ill septic patients compared to intermittent administration.
Anatomy, Pollen and Seed Morphology of Endemicspecies Verbascum Globiferumhub.-Mor. and V. Lysiosepalum Hub.-Mor. (Scrophulariaceae)In Diyarbakir, Turkey and Their Taxonomic Importance

Verbascum globiferumHub. -Mor. and V. lysiosepalum Hub. -Mor.are endemic to Turkey which is a center of endemism for Verbascum species. This study gives the anatomical, palynological and seed micromorphological features of V. globiferum and V. lysiosepalumwhich grow in Diyarbakır. The xylem elements occupy a large area in the root cross-sections of the species. In stem cross-sections, the upper part of the epidermis cells is surrounded by a separate cuticle layer and the pith region covers a large area. In the leaves, the main vein is shapped as collateral bundle. Pollen grains are tricolporate-tricolpate, oblate-spheroidal, and exine ornamentation is reticulate. Seeds are brown and oblong-ovate to prismatic and alveolate. The seed coat ornamentation is irregular with polygonal cells, with densely, distinct vesicles.The capsules are pubescent, covered with stellate and branched hairy or glandular hairs.The seed displayed that substantial taxonomic understanding can be acquired from examining the seed characteristics of Verbascum, particularly at the species level. Bangladesh J. Plant Taxon. 30(2): 201-212, 2023 (December)