Miracle-dz/UniFAR-FTUs huggingface dataset:
Exploring Attitudes of Mandatory Volunteers: The Role of Perceived Organizational Support, Role Clarity, and Self-Efficacy Toward Service

This study attempted to investigate the effects of perceived organizational support (POS) and role clarity on volunteer satisfaction, the mediating role of attitudes toward volunteering in the relationship between volunteer satisfaction and attitudes toward civic participation, and the moderating role of self-efficacy toward service in the relationships between POS, role clarity, and volunteer satisfaction among mandatory volunteers. Using data conducted at a major event in Wuhan, China, results showed that POS and role clarity predicted volunteer satisfaction. Volunteer satisfaction positively influenced attitudes toward volunteering, which is linked to attitudes toward civic participation. Self-efficacy toward service moderated the associations between POS, role clarity, and volunteer satisfaction, highlighting its essential role in strengthening the effects of organizational climate factors on volunteer satisfaction. Our findings underline the important role of organizations in increasing mandatory volunteers’ satisfaction that affects positive attitudes toward volunteering, leading to enhanced attitudes toward civic participation.
Miniaturized circular microstrip antenna designed with quasiperiodic sector metamaterials

Miniaturized circular microstrip antennas (CMSAs) are designed by loading new quasiperiodic sector metamaterials in the substrate. The resonance performances of new antennas are numerically studied. One particular metamaterial CMSA is further experimentally demonstrated operating in the 3.5 GHz band. The practical new CMSA has a patch diameter of 20 mm fabricated on substrates with a dielectric constant of 3. The normalized diameter is hence only about 0. 4λg (or 0.232λ0) which is beyond the 0. 58λg limitation for a conventional CMSA. The bandwidth and antenna gain characteristics for the new antenna are also evaluated in experiments. Both are observed reasonably high for such a compact CMSA.
Competence building in child mental health -A Norway-Cambodia transcultural experience

Abstract The prevalence of mental health and neurodevelopmental disorders in young people is high in low- and middle-income countries. Collaboration between institutions from high-income countries and institutions in resource-poor settings may enhance professional competence. This may be a key to bridging the gap between service needs and ability to meet those needs. However, there are challenging issues in transferring knowledge from a Western context to a different cultural and socioeconomic situation. The aim of the present study is to describe significant aspect of a transcultural competence building project in Cambodia in child mental health from the perspective of the staff. A Norwegian expert team developed and implemented a program at Centre for Child and Adolescent Mental Health (Caritas-CCAMH) in collaboration with the staff two weeks per year over a 14-year period. The study has a qualitative approach using thematic analysis of the transcripts from a focus-group interview with 11 staff members at the end of the 14-year period. The multidisciplinary staff described a learning process characterized by collaboration in planning and implementation. Mixing theory and practice in clinical case discussions with a bio-psycho-social perspective was perceived as the cornerstone of the teaching process. A pedagogical strategy that involved constant reflection back and forth enabled the customization of the content and method of capacity building despite the differences in socio-economic conditions and learning styles. This model of continuity, low-investment, and low-intensity capacity-building may enrich the child and adolescent mental health settings in low- and middle-income countries.
Pharmacogenetic Interventions Improve the Clinical Outcome of Treatment-Resistant Autistic Spectrum Disorder Sufferers

BACKGROUND: Autistic spectrum disorders (ASD) are severe neurodevelopmental alterations characterised by deficits in social communication and repetitive and restricted behaviours. About a third of patients receive pharmacological treatment for comorbid symptoms. However, 30–50% do not respond adequately and/or present severe and long-lasting side effects. METHODS: Genetic variants in CYP1A2, CYP2C19, CYP2D6 and SLC6A4 were investigated in N = 42 ASD sufferers resistant to pharmacological treatment. Clinical recommendations based on their pharmacogenetic profiles were provided within 24–48 h of receiving a biological sample. RESULTS: A total of 39 participants (93%) improved after the pharmacogenetic intervention according to their CGI scores (difference in basal-final scores: 2.26, SD 1.55) and 37 participants (88%) according to their CGAS scores (average improvement of 20.29, SD 11.85). Twenty-three of them (55%) achieved symptom stability (CGI ≤ 3 and CGAS improvement ≥ 20 points), requiring less frequent visits to their clinicians and hospital stays. Furthermore, the clinical improvement was higher than that observed in a control group (N = 62) with no pharmacogenetic interventions, in which 66% responded to treatment (difference in CGI scores: −0.87, SD 9.4, p = 1 × 10−5; difference in CGAS scores: 6.59, SD 7.76, p = 5 × 10−8). CONCLUSIONS: The implementation of pharmacogenetic interventions has the potential to significantly improve the clinical outcomes in severe comorbid ASD populations with drug treatment resistance and poor prognosis.
Indian Diabetes Risk Score (IDRS) as a strong predictor of diabetes mellitus: A cross sectional study among urban population of Jhalawar, Rajasthan

Introduction: The patients with Type 2 diabetes Mellitus may often remain asymptomatic for a longer period of time. The Indian Diabetes Risk Score (IDRS), a simple screening tool for prediction of undiagnosed diabetes. Objective: Validation of IDRS with standard test for type 2 diabetes among urban population of Jhalawar, Rajasthan. Material and Methods: A Community based Cross-sectional study was carried out in urban field practice area of Department of Community Medicine, Jhalawar Medical College, Jhalawar, Rajasthan. The study was conducted using a two-stage sampling design. A predesigned, pretested proforma and Indian Diabetes Risk Score (IDRS) sheet was used to collect data from the study participants. The IDRS is based on four parameters: age, family history of diabetes, waist circumference and physical inactivity. Data was collected using the World Health Organization stepwise approach to surveillance (STEPS). Results: Among 450 participants, 12.7% participants were in low risk, 59.1% were in moderate risk and 28.2% were in high risk of developing diabetes according to IDRS score. IDRS score of ? 60 turned out to be the best cut point for identifying undiagnosed diabetes with sensitivity 92.3% and specificity 82.6%. Positive Predictive value and Negative Predictive value were 47.3% and 98.5% respectively. Conclusion: Association of IDRS was found significant with diabetes. IDRS score of ? 60 turned out to be the best cut point for identifying undiagnosed diabetes. IDRS is found valid screening tool for early detection of Diabetes.
Visual Servoed Autonomous Landing of an UAV on a Catamaran in a Marine Environment

This paper introduces a procedure for autonomous landing of a quadrotor on an unmanned surface vehicle in a marine environment. The relative pose and velocity of the vehicle with respect to the quadrotor are estimated using a combination of data coming from a vision system, which recognizes a set of AprilTags located on the vehicle itself, and an ultrasonic sensor, to achieve further robustness during the final landing phase. The considered software and hardware architecture is provided, and the details about the landing procedure are presented. Software-in-the-loop tests were performed as a validation step for the proposed algorithms; to recreate realistic conditions, the movements of the landing platform have been replicated from data of a test in a real marine environment. In order to provide further proof of the reliability of the vision system, a video sequence from a manual landing of a quadrotor on the surface vehicle in a real marine environment has been processed, and the results are presented.
Lycorine Alkaloid and Crinum americanum L. (Amaryllidaceae) Extracts Display Antifungal Activity on Clinically Relevant Candida Species

Candida species are the main fungal agents causing infectious conditions in hospital patients. The development of new drugs with antifungal potential, increased efficacy, and reduced toxicity is essential to face the challenge of fungal resistance to standard treatments. The aim of this study is to evaluate the in vitro antifungal effects of two crude extracts of Crinum americanum L. , a rich alkaloid fraction and lycorine alkaloid, on the Candida species. As such, we used a disk diffusion susceptibility test, determined the minimum inhibitory concentration (MIC), and characterized the components of the extracts using Electrospray Ionization Fourier Transform Ion Cyclotron Resonance Mass Spectrometry (ESI FT-ICR MS). The extracts were found to have antifungal activity against various Candida species. The chemical characterization of the extracts indicated the presence of alkaloids such as lycorine and crinine. The Amaryllidaceae family has a promising antifungal potential. Furthermore, it was found that the alkaloid lycorine directly contributes to the effects that were observed for the extracts and fraction of C. americanum.
Skin Manifestation Induced by Immune Checkpoint Inhibitors

Abstract In accordance with recent therapeutic progress of immune checkpoint inhibitors for certain cancers, various disorders are induced as immune-related adverse events (irAEs) affecting the skin, gut, thyroid gland, lung, and liver. Among such irAEs, mucocutaneous manifestation is the most common. Cutaneous manifestations are categorized into several groups, ie, inflammatory reactions, immunobullous reactions, alterations of epidermal keratinocytes, and alterations of epidermal melanocytes; however, there are additionally various cutaneous toxicities, unclassified into those groups. Blocking of programmed cell death 1 (PD-1)/programmed cell death ligand 1(PDL1) can lead to the induction of autoimmune reaction, via activation of cytotoxic T cells, inhibition of regulatory T cell function, and alteration of cytokine balance. Similarly, blockade of cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) reduces the suppressive function of regulatory T cells. Due to those mechanisms, various autoimmune conditions can be induced, in addition to nonspecific drug eruptions. Dermatologists should be aware of various types of those mucocutaneous manifestations, either common or rare, as well as the management of such conditions. Herein, various mucocutaneous manifestations of irAEs and cases involving Japanese patients have been described, based on a single institute’s experience.
Development of low power non-thermal plasma jet and optimization of operational parameters for treating dyes and emerging contaminants

Non-thermal plasma has emerged as an effective treatment system against the latest class of highly recalcitrant and toxic environmental pollutants termed emerging contaminants (ECs). In the present work, a detailed experimental study is carried out to evaluate the efficacy of a non-thermal plasma jet with two dyes, Rd. B and Met. Blue, as model contaminants. The plasma jet provided a complete dye decoloration in 30 min with an applied voltage of 6.5 kVp−p. ·OH, having the highest oxidation potential, acts as the main reactive species, which with direct action on contaminants also acts indirectly by getting converted into H2O2 and O3. Further, the effect of critical operational parameters viz, sample pH, applied voltage (4.5‒6.5 kVp−p), conductivity (5‒20 mS cm−1), and sample distance on plasma treatment efficacy was also examined. Out of all the assessed parameters, the applied voltage and sample conductivity was found to be the most significant operating parameters. A high voltage and low conductivity favored the dye decoloration, while the pH effect was not that significant. To understand the influence of plasma discharge gas on treatment efficacy, all the experiments are conducted with argon and helium gases under the fixed geometrical configuration. Both the gases provided a similar dye decoloration efficiency. The DBD plasma system with complete dye removal also rendered maximum mineralization of 73% for Rd. B, and 60% for Met. Blue. Finally, the system’s efficiency against the actual ECs (four pharmaceutical compounds, viz, metformin, atenolol, acetaminophen, and ranitidine) and microbial contaminant (E. coli) was also tested. The system showed effectivity in the complete removal of targeted pharmaceuticals and a log2.5 E. coli reduction. The present systematic characterization of dye degradation could be of interest to large communities working towards commercializing plasma treatment systems.
Confirming Parkinson Disease Diagnosis: Patterns of Diagnostic Changes by Movement Disorder Specialists

Background The American Academy of Neurology Parkinson Disease (PD) quality measures include an annual diagnostic review. Objective To investigate the frequency and pattern of changes in diagnoses between PD and other causes of parkinsonism. Methods This prospective longitudinal cohort study included consented patients diagnosed with PD at least once and a minimum of two times at the Movement Disorders Center between 2002 and 2017. Movement disorder specialists confirmed and documented diagnoses at every visit. Longitudinal changes in diagnoses were identified across visits. Results Of 1567 patients with parkinsonism, 174 had non-PD parkinsonism with no change over time. Of 1393 patients diagnosed with PD at least once, 94% (N = 1308) had no change of diagnosis over time and 6% (N = 85) had a change of diagnosis including PD ⟷ drug-induced parkinsonism (DIP) (27.1%), PD ⟷ multiple system atrophy (MSA) (20.0%), PD ⟷ progressive supranuclear palsy (PSP) (18.8%), PD ⟷ Lewy body dementia (DLB) (16.5%), PD⟷ vascular parkinsonism (9.4%), more than two diagnoses (4.7%), and PD ⟷ corticobasal syndrome (CBS) (3.5%). The direction of diagnostic switches was as follows: PD ⟶ other parkinsonism diseases (36.5%), other parkinsonism diseases ⟶ PD (31.8%), and 31.8% of multiple switches. There were no significant differences in duration of follow-up, age at first visit, gender, race, marital status, education, income, cognition, or employment between the stable and unstable groups. Diagnostic change was associated with greater PD severity and greater medical comorbidity. Conclusion Over a 15-year period, movement disorder specialists changed their clinical diagnosis of PD in 6% of patients. The most common diagnostic switches, to or from PD, were DIP, MSA, PSP, and DLB. This study describes routine clinical diagnostic patterns in the absence of pathologic confirmation. The presence of diverse diagnostic changes over time underscores the value of confirming PD diagnosis.
Impact of Food-Based Weight Loss Interventions on Gut Microbiome in Individuals with Obesity: A Systematic Review

The observation that the gut microbiota is different in healthy weight as compared with the obese state has sparked interest in the possible modulation of the microbiota in response to weight change. This systematic review investigates the effect of food-based weight loss diets on microbiota outcomes (α-diversity, β-diversity, relative bacterial abundance, and faecal short-chain fatty acids, SCFAs) in individuals without medical comorbidities who have successfully lost weight. Nineteen studies were included using the keywords ‘obesity’, ‘weight loss’, ‘microbiota’, and related terms. Across all 28 diet intervention arms, there were minimal changes in α- and β-diversity and faecal SCFA concentrations following weight loss. Changes in relative bacterial abundance at the phylum and genus level were inconsistent across studies. Further research with larger sample sizes, detailed dietary reporting, and consistent microbiota analysis techniques are needed to further our understanding of the effect of diet-induced weight loss on the gut microbiota.
Evaluating Baltimore's Aerial Investigation Research Pilot Program

iii Acknowledgments. iii Summary . iv Evaluating the AIR program in Baltimore . iv AIR Research methodology . v Findings on clearance rates . v Findings on crime rates . vi Considerations for policymakers . vi Figures and Tables . x Figures . x Tables . x Chapter
Do No Harm Policy for Minds in Other Substrates

Various authors have argued that in the future not only will it be technically feasible for human minds to be transferred to other substrates, but this will become, for most humans, the preferred option over the current biological limitations. It has even been claimed that such a scenario is inevitable in order to solve the challenging, but imperative, multi-agent value alignment problem. In all these considerations, it has been overlooked that, in order to create a suitable environment for a particular mind – for example, a personal universe in a computational substrate – numerous other potentially sentient beings will have to be created. These range from non-player characters to subroutines. This article analyzes the additional suffering and mind crimes that these scenarios might entail. We offer a partial solution to reduce the suffering by imposing on the transferred mind the perception of indicators to measure potential suffering in non-player characters. This approach can be seen as implementing literal empathy through enhanced cognition.
Intrauterine Growth Restriction with and without Pre-Eclampsia: Pregnancy Outcome and Placental Findings

Background & Objective: Accordingly, this study aimed to assess pregnancy outcomes and pathological findings of the placenta caused by intrauterine growth restriction (IUGR) with or without pre-eclampsia (PE). Materials & Methods: This cohort study was conducted on two groups: Group I was PE-induced IUGR (PE-IUGR), and group II was idiopathic IUGR (I-IUGR). Pregnancy and neonatal outcomes were evaluated in both groups. The placental assessment was also performed based on pathological findings. Data were compiled and analyzed by SPSS 21. An analytical study was conducted on the groups based on t (or non-parametric Mann-Whitney), chi-square, and Fisher’s exact tests. Results: The findings of this study showed that maternal age, body mass index (BMI), the incidence of preterm delivery, and low birth weight were higher in the PE-IUGR group ( P <0.001 in all) than in the I-IUGR group, and the difference was statistically significant. Additionally, circulatory disorders and impaired anomalies were higher in the PE-IUGR group ( P >0.001) than in the I-IUGR group. Conclusion: Placental disorders and reduced blood flow to the fetus due to placental disorders might lead to low birth weight and preterm delivery.
The Case for Using the MVPF in Empirical Welfare Analysis

This paper outlines the case for using the Marginal Value of Public Funds (MVPF) in empirical welfare analysis. It compares the MVPF approach with more traditional welfare metrics such as the Cost-Beneﬁt Ratio and the Net Social Beneﬁts criterion. It outlines the advantages of the MVPF approach relative to these metrics. In building the case for the MVPF, this paper also addresses several misconceptions about the MVPF that appear in recent literature.
Ocular Barriers and Their Influence on Gene Therapy Products Delivery

The eye is formed by tissues and cavities that contain liquids whose compositions are highly regulated to ensure their optical properties and their immune and metabolic functions. The integrity of the ocular barriers, composed of different elements that work in a coordinated fashion, is essential to maintain the ocular homeostasis. Specialized junctions between the cells of different tissues have specific features which guarantee sealing properties and selectively control the passage of drugs from the circulation or the outside into the tissues and within the different ocular compartments. Tissues structure also constitute selective obstacles and pathways for various molecules. Specific transporters control the passage of water, ions, and macromolecules, whilst efflux pumps reject and eliminate toxins, metabolites, or drugs. Ocular barriers, thus, limit the bioavailability of gene therapy products in ocular tissues and cells depending on the route chosen for their administration. On the other hand, ocular barriers allow a real local treatment, with limited systemic side-effects. Understanding the different barriers that limit the accessibility of different types of gene therapy products to the different target cells is a prerequisite for the development of efficient gene delivery systems. This review summarizes actual knowledge on the different ocular barriers that limit the penetration and distribution of gene therapy products using different routes of administration, and it provides a general overview of various methods used to bypass the ocular barriers.
Design and Optimization of Gate Driver Integrated Multichip 3D GaN Power Module

Gallium Nitride (GaN) high electron mobility transistors (HEMT) are excellent power semiconductor devices due to their superior material properties, compared to their silicon counterparts. It has demonstrated fast switching speed with high dV/dt, enabling the designer to push switching frequency towards MHz range. However, traditional wire bonded packaging becomes a limiting factor in fully harnessing the benefits offered by these advanced power devices, as it is likely to introduce voltage overshoot, oscillation, parasitic turn-on, and electromagnetic interference (EMI) issues; and thus, improved, and advanced packaging structures are a must to bridge the gap. Besides, the unique electrical behavior and footprint of GaN compared to silicon and silicon carbide, make them to have different requirements for power module integration. To seek a viable solution, a globally optimized double-sided cooled, gate driver integrated 650V/60A GaN half-bridge power module is presented herein. The proposed 3D integrated hybrid solution delivers an optimized package, having power loop inductance and thermal resistance as low as 0.91 nH and 0.38° C/W respectively, which is verified using simulation and experimental results. The overall utility of the design improved proportionately by introducing simple, yet effective electrical/thermal co-design approaches, which can be applied to future power modules, designed for separate applications.
Behaviour Analysis of Open-Source Firewalls Under Security Crisis

Nowadays, in this COVID era, work from home is quietly more preferred than work from the office. Due to this, the need for a firewall has been increased day by day. Every organization uses the firewall to secure their network and create VPN servers to allow their employees to work from home. Due to this, the security of the firewall plays a crucial role. In this paper, we have compared the two most popular open-source firewalls named pfSense and OPNSense. We have examined the security they provide by default without any other attachment. To do this, we performed four different attacks on the firewalls and compared the results. As a result, we have observed that both provide the same security still pfSense has a slight edge when an attacker tries to perform a Brute force attack over OPNSense.