Miracle-dz/UniFAR-FTUs huggingface dataset:
Effect of amount of biomaterial used for maxillary sinus lift on volume maintenance of grafts

Background Regardless of the kind of biomaterial used for the graft, it is clear that, over time, the graft undergoes dimensional changes that could influence the final bone volume obtained, which could alter the stability of the installed implants. The aim of the present study was to compared and correlated the graft behavior with the amount (in grams) of xenogeneic and alloplastic biomaterials used in grafts for maxillary sinus lift. Material and Methods This retrospective cohort study used 148 CBCT images of 74 grafts from 68 maxillary sinuses lift patients in a university, post-graduate clinic. The weights of biomaterials, categorized in intervals according to amount used, were correlated with the graft volumes at V1 (10 days) and V2 (180 days). Kruskal-Wallis test was used to evaluate the possible bias effect of weight on graft maintenance. Results Mean weights of biomaterials used were: Bio-Oss Small® (1.58g); Bio-Oss Large® (1.35g); Endobon® (0.72g); BoneCeramic®+Emdogaim® (0.96g); Cerasorb® (1.13g) and Osteogen® (2.70g). No significant differences (p>0.05). Were found for the influence of these mean amounts in graft maintenance: Bio-Oss Small® (18); Bio-Oss Large® (10); Endobon® (17); BoneCeramic®+Emdogaim® (10); Cerasorb® (11); and Osteogen® (08) at V1 and V2. However, when biomaterials were categorized by intervals, all Cerasorb® interval groups showed statistically significant differences (p<0.001) in graft volume at V2. Conclusions The amounts of the biomaterials used could influence the final volume; depending on the biomaterial characteristics. Implant installation was possible with all studied grafts, although graft volume shrinkage should be considered when selecting biomaterial for sinus lift. Key words:Biocompatible materials; cone beam computed tomography; maxillary sinus; hydroxyapatites.
Cocoa colonic phenolic metabolites are related to HDL-cholesterol raising effects and methylxanthine metabolites and insoluble dietary fibre to anti-inflammatory and hypoglycemic effects in humans

Background In many cocoa intervention studies, health outcomes are related to cocoa components without taking into account the bioavailability of the main bioactive components: phenolic compounds and methylxanthines. Methods The present work associates the results of bioavailability and randomised controlled crossover studies in humans carried out with similar cocoa products, so that the main phenol and methylxanthine metabolites observed in plasma and urine are associated to the health effects observed in the chronic studies. We outstand that doses of cocoa and consumption rate used are realistic. In the bioavailability study, a conventional (CC) and a methylxanthine-polyphenol rich (MPC) cocoa product were used, whereas in the chronic study a dietary fibre-rich (DFC) and a polyphenol-rich (PC) product were studied in healthy and cardiovascular risk subjects. Results and Discussion The main phenolic metabolites formed after CC and MPC intake, 5-(4′-hydroxyphenyl)-γ-valerolactone-3′-sulfate, 3′-methyl-epicatechin-5-sulfate, 4-hydroxy-5-(4′-hydroxyphenyl)valeric acid-sulfate, 5-phenyl-γ-valerolactone--sulfate and 5-(4′-hydroxyphenyl)-γ-valerolactone-3′-glucuronide, may contribute to the changes in cholesterol (and indirectly HDL-cholesterol) observed after the regular intake of both DFC and PC, in healthy and cardiovascular risk subjects, whereas 7-methylxanthine (the main cocoa methylxanthine metabolite) and theobromine, together with its content in insoluble dietary fibre, may be responsible for the decrease of IL-1β and hypoglycemic effects observed with DFC. With both phenolic and methylxanthine metabolites a strong dose–response effect was observed. Conclusion After the regular consumption of both DFC and PC, positive changes were observed in volunteer’s lipid profile, which may be related to the long-lasting presence of colonic phenolic metabolites in blood. In contrast, the anti-inflammatory and hypoglycemic effects were only observed with DFC, and these may be related to methylxanthine metabolites, and it is likely that insoluble dietary fibre may have also played a role.
High-sensitivity multispeckle diffuse correlation spectroscopy

Abstract. Significance: Cerebral blood flow is an important biomarker of brain health and function as it regulates the delivery of oxygen and substrates to tissue and the removal of metabolic waste products. Moreover, blood flow changes in specific areas of the brain are correlated with neuronal activity in those areas. Diffuse correlation spectroscopy (DCS) is a promising noninvasive optical technique for monitoring cerebral blood flow and for measuring cortex functional activation tasks. However, the current state-of-the-art DCS adoption is hindered by a trade-off between sensitivity to the cortex and signal-to-noise ratio (SNR). Aim: We aim to develop a scalable method that increases the sensitivity of DCS instruments. Approach: We report on a multispeckle DCS (mDCS) approach that is based on a 1024-pixel single-photon avalanche diode (SPAD) camera. Our approach is scalable to >100,000 independent speckle measurements since large-pixel-count SPAD cameras are becoming available, owing to the investments in LiDAR technology for automotive and augmented reality applications. Results: We demonstrated a 32-fold increase in SNR with respect to traditional single-speckle DCS. Conclusion: A mDCS system that is based on a SPAD camera serves as a scalable method toward high-sensitivity DCS measurements, thus enabling both high sensitivity to the cortex and high SNR.
The Relationship Between Convective Clustering and Mean Tropical Climate in Aquaplanet Simulations

Convective clustering, the spatial organization of tropical deep convection, can manifest itself in two ways: through a decrease in the total area covered by convection and/or through a decrease in the number of convective areas. Much of our current understanding of convective clustering comes from simulations in idealized radiative convective equilibrium (RCE) configurations. In these simulations the two forms of convective clustering tend to covary, and their individual effects on the climate are thus hard to disentangle. This study shows that in aquaplanet simulations with more realistic boundary conditions, such as meridional gradients of surface temperature and rotational forces, the two aspects of convective clustering are not equivalent and are associated with different impacts on the large‐scale climate. For instance, reducing the convective area in the equatorial region in the aquaplanet simulations results in broader meridional humidity and rain distributions and in lower tropospheric temperatures throughout the tropics. By contrast, the number of convective regions primarily impacts the zonal variance of humidity‐related quantities in the aquaplanet simulations, as the distribution of convective regions affects the size of the subsidence regions and thereby the moistening influence of convective regions. The aquaplanet simulations confirm many other qualitative results from RCE simulations, such as a reduction of equatorial tropospheric humidity when the area covered by convection diminishes.
Utilizing a novel unified healthcare model to compare practice patterns between telemedicine and in-person visits

Objective Telemedicine practice has been shown to vary from clinical guidelines. Variations in practice patterns may be caused by disruptions in the continuity of care between traditional and telemedicine providers. This study compares virtual and in-person visits in Stanford’s ClickWell Care (CWC) – where patients see the same provider for both visit modalities. Methods Clinical data for two years of patient encounters at CWC from January 2015–2017 (5772 visits) were obtained through Stanford STRIDE. For the 20 most common visit categories, including 17 specific diagnoses, we compared the frequency of prescriptions, labs, procedures, and images ordered, as well as rates of repeat visits. Results For the 17 specific diagnoses, there are no differences in labs ordered. Two diagnoses show differences in images ordered, and four differences in prescriptions. Overall, there are more labs (0.16 virtual, 0.33 in-person p < 0.0001) and images ordered (0.07 virtual, 0.16 in-person, p < 0.0001) for in-person visits – due mainly to general medical exam visits. Repeat visits were more likely after in-person visits (19% virtual, 38% in-person, p < 0.0001), 10 out of 17 specific diagnoses showed differences in visit frequency between visit modalities. Visits for both anxiety (5.3x, p < 0.0001) and depression (5.1x, p < 0.0001) were much more frequent in the virtual setting. Conclusions Prescriptions, labs, and images ordered were similar between in-person and virtual visits for most diagnoses. Overall however, for in-person visits we find increased orders for labs and images, primarily from general medical exams. Finally, for anxiety and depression patients show clear preferences for virtual visits.
Comparative Analysis of the Vlasiator Simulations and MMS Observations of Multiple X‐Line Reconnection and Flux Transfer Events

The Vlasiator hybrid‐Vlasov code was developed to investigate global magnetospheric dynamics at ion‐kinetic scales. Here we focus on the role of magnetic reconnection in the formation and evolution of magnetic islands at the low‐latitude magnetopause, under southward interplanetary magnetic field conditions. The simulation results indicate that (1) the magnetic reconnection ion kinetics, including the Earthward pointing Larmor electric field on the magnetospheric side of an X‐point and anisotropic ion distributions, are well‐captured by Vlasiator, thus enabling the study of reconnection‐driven magnetic island evolution processes, (2) magnetic islands evolve due to continuous reconnection at adjacent X‐points, “coalescence” which refers to the merging of neighboring islands to create a larger island, “erosion” during which an island loses magnetic flux due to reconnection, and “division” which involves the splitting of an island into smaller islands, and (3) continuous reconnection at adjacent X‐points is the dominant source of magnetic flux and plasma to the outer layers of magnetic islands resulting in cross‐sectional growth rates up to + 0.3 RE2/min. The simulation results are compared to the Magnetospheric Multiscale (MMS) measurements of a chain of ion‐scale flux transfer events (FTEs) sandwiched between two dominant X‐lines. The MMS measurements similarly reveal (1) anisotropic ion populations and (2) normalized reconnection rate ~0.18, in agreement with theory and the Vlasiator predictions. Based on the simulation results and the MMS measurements, it is estimated that the observed ion‐scale FTEs may grow Earth‐sized within ~10 min, which is comparable to the average transport time for FTEs formed in the subsolar region to the high‐latitude magnetopause. Future simulations shall revisit reconnection‐driven island evolution processes with improved spatial resolutions.
In silico analysis of CpG islands and miRNAs potentially regulating the JAK-STAT signalling pathway

Introduction Searching for new therapeutic possibilities constitutes a challenge for modern medicine and an answer to better understanding of molecular mechanisms of pro-inflammatory diseases. The JAK-STAT pathway plays an important role in the inflammatory processes, which is supported by the fact that its inhibitors are used to treat, for instance, psoriasis and rheumatoid arthritis. Aim To determine whether the epigenetic mechanisms – methylation of gene promotion regions and miRNAs may serve as a new therapeutic strategy for JAK-STAT pathway inhibition. Material and methods Basing on MethPrimer (plus CpG Island Prediction) program and microrna.org database of the said mechanism in the regulation of the JAK-STAT signalling pathway, the gene expression was performed, indicating or excluding the possibility of their use as new potential therapeutic strategies. Results A different number of CpG islands (CGI) for each gene (JAK1-4 CGI; JAK2-2 CGI; JAK3-5 CGI, TYK2-6 CGI; STAT1-2 CGI; STAT2-1 CGI; STAT3-3 CGI; STAT5A-4 CGI; STAT5B-3 CGI) might be a new therapeutic goal. What is more, our results show that genes associated with JAK-STAT signalling pathways can be regulated by miRNAs (JAK1-42 miRNAs; JAK2-47 miRNAs; JAK3-15 miRNAs, TYK2-4 miRNAs; STAT1-17 miRNAs; STAT2-30 miRNAs, STAT3-36 miRNAs, STAT4-15 miRNAs; STAT5A-10 miRNAs; STAT5B-23 miRNAs). Conclusions The epigenetic mechanisms of the regulation of the JAK-STAT signalling pathway gene expression constitute a promising new therapeutic strategy for treatment of those diseases, during which disorders are observed in gene expression models of the analysed signalling pathway.
Risk to human health related to the presence of perfluoroalkyl substances in food

Abstract The European Commission asked EFSA for a scientific evaluation on the risks to human health related to the presence of perfluoroalkyl substances (PFASs) in food. Based on several similar effects in animals, toxicokinetics and observed concentrations in human blood, the CONTAM Panel decided to perform the assessment for the sum of four PFASs: PFOA, PFNA, PFHxS and PFOS. These made up half of the lower bound (LB) exposure to those PFASs with available occurrence data, the remaining contribution being primarily from PFASs with short half‐lives. Equal potencies were assumed for the four PFASs included in the assessment. The mean LB exposure in adolescents and adult age groups ranged from 3 to 22, the 95th percentile from 9 to 70 ng/kg body weight (bw) per week. Toddlers and ‘other children’ showed a twofold higher exposure. Upper bound exposure was 4‐ to 49‐fold higher than LB levels, but the latter were considered more reliable. ‘Fish meat’, ‘Fruit and fruit products’ and ‘Eggs and egg products’ contributed most to the exposure. Based on available studies in animals and humans, effects on the immune system were considered the most critical for the risk assessment. From a human study, a lowest BMDL 10 of 17.5 ng/mL for the sum of the four PFASs in serum was identified for 1‐year‐old children. Using PBPK modelling, this serum level of 17.5 ng/mL in children was estimated to correspond to long‐term maternal exposure of 0.63 ng/kg bw per day. Since accumulation over time is important, a tolerable weekly intake (TWI) of 4.4 ng/kg bw per week was established. This TWI also protects against other potential adverse effects observed in humans. Based on the estimated LB exposure, but also reported serum levels, the CONTAM Panel concluded that parts of the European population exceed this TWI, which is of concern.
Effect of fish oil and telmisartan on dehydroepiandrosterone‐induced polycystic ovarian syndrome in rats: The role of oxidative stress, transforming growth factor beta‐1, and nuclear factor kappa B

Abstract Our aim was to explore the effect of telmisartan and/or fish oil on dehydroepiandrosterone (DHEA)‐induced PCOS in rats. Sixty female rats were divided into six equal groups as follows: Control; DHEA‐induced PCOS; DHEA + Telmisartan; DHEA + Fish oil; DHEA + Carboxymethyl cellulose; and DHEA + Telmisartan +Fish oil group. Plasma sex hormones, anthropometric measurements, and the glycemic indices were measured. Tissue oxidative stress parameters and the proinflammatory cytokines were assessed. The ovaries were subjected to histopathological and electron microscopic examination. Telmisartan and/or fish oil induced significant improvement of insulin resistance with amelioration of oxidative stress and inflammation compared to PCOS group. Also, telmisartan and/or fish oil restored the hormonal levels and the anthropometric measurements to the normal values. This was significant with telmisartan/fish oil combination compared to the use of each of these agents alone. In conclusion, this combination may represent a promising hope for amelioration of PCOS.
Early detection of black Sigatoka in banana leaves using hyperspectral images

Premise Black Sigatoka is one of the most severe banana (Musa spp.) diseases worldwide, but no methods for the rapid early detection of this disease have been reported. This paper assesses the use of hyperspectral images for the development of a partial‐least‐squares penalized‐logistic‐regression (PLS–PLR) model and a hyperspectral biplot (HS biplot) as a visual tool for detecting the early stages of black Sigatoka disease. Methods Young (three‐month‐old) banana plants were inoculated with a conidia suspension of the black Sigatoka fungus (Pseudocercospora fijiensis). Selected infected and control plants were evaluated using a hyperspectral imaging system at wavelengths in the range of 386–1019 nm. PLS–PLR models were run on the hyperspectral data set. The prediction power was assessed using leave‐one‐out cross‐validation as well as external validation. Results The PLS–PLR model was able to predict the presence of the disease with a 98% accuracy. The wavelengths with the highest contribution to the classification ranged from 577 to 651 nm and from 700 to 1019 nm. Discussion PLS–PLR and HS biplot effectively estimated the presence of black Sigatoka disease at the early stages and can be used to graphically represent the relationship between groups of leaves and both visible and near‐infrared wavelengths.
Malvidin induces hepatic stellate cell apoptosis via the endoplasmic reticulum stress pathway and mitochondrial pathway

Abstract Blueberries have great beneficial effects due to high level of anthocyanins, especially malvidin. Hepatic stellate cells (HSCs) can be activated and increase excessive extracellular matrix (ECM) components, which play a central role in liver fibrogenesis. Therefore, activated HSC’s apoptosis can be induced to recover liver fibrosis. Malvidin's effects on apoptosis in rat activated hepatic stellate T6 cells (HSC‐T6) in vitro were investigated here. High concentration of malvidin was found to significantly induce apoptosis, activate caspase‐3, increase malondialdehyde, upregulate Bax, but downregulate Bcl‐2. Moreover, malvidin upregulated the protein levels of some endoplasmic reticulum stress (ERS)‐typical markers, including caspase‐12, glucose‐regulated protein 78 (GRP78), and CCAAT/enhancer‐binding protein (C/EBP) homologous protein (CHOP), suggesting that malvidin induced HSC apoptosis by the ERS apoptosis pathway as well as the mitochondrial‐dependent pathway. These findings indicated that blueberry anthocyanins, especially malvidin, could induce activated hepatic stellate cell apoptosis and might act as one kind of functional food ingredient or a novel nutraceutical beneficial for liver health.
Double Tropopauses and the Tropical Belt Connected to ENSO

A detailed analysis of double tropopause (DT) occurrences requires vertically well resolved, accurate, and globally distributed information on the troposphere‐stratosphere transition zone. Here, we use radio occultation observations from 2001 to 2018 with such properties. We establish a connection between El Niño‐Southern Oscillation (ENSO) phases and the distribution of DTs by analyzing the global and seasonal DT characteristics. The seasonal distribution of DTs reveals several hotspot locations, such as near the subtropical jet stream and over high mountain ranges, where DTs occur particularly often. In this study, we detect a higher number of DTs during the cold La Niña state while warmer El Niño events result in lower DT rates, affecting the structure of the tropopause region. Close to the Niño 3 region, this relates to a much lower first lapse rate tropopause altitude during La Niña and corresponds to an apparent narrowing of the tropical belt there.
Effects of ventilation on the indoor spread of COVID-19

Abstract Although the relative importance of airborne transmission of the SARS-CoV-2 virus is controversial, increasing evidence suggests that understanding airflows is important for estimation of the risk of contracting COVID-19. The data available so far indicate that indoor transmission of the virus far outstrips outdoor transmission, possibly due to longer exposure times and the decreased turbulence levels (and therefore dispersion) found indoors. In this paper we discuss the role of building ventilation on the possible pathways of airborne particles and examine the fluid mechanics of the processes involved.
GISS‐E2.1: Configurations and Climatology

This paper describes the GISS‐E2.1 contribution to the Coupled Model Intercomparison Project, Phase 6 (CMIP6). This model version differs from the predecessor model (GISS‐E2) chiefly due to parameterization improvements to the atmospheric and ocean model components, while keeping atmospheric resolution the same. Model skill when compared to modern era climatologies is significantly higher than in previous versions. Additionally, updates in forcings have a material impact on the results. In particular, there have been specific improvements in representations of modes of variability (such as the Madden‐Julian Oscillation and other modes in the Pacific) and significant improvements in the simulation of the climate of the Southern Oceans, including sea ice. The effective climate sensitivity to 2 × CO2 is slightly higher than previously at 2.7–3.1°C (depending on version) and is a result of lower CO2 radiative forcing and stronger positive feedbacks.
Nucleation of Stick‐Slip Instability Within a Large‐Scale Experimental Fault: Effects of Stress Heterogeneities Due to Loading and Gouge Layer Compaction

Geodetic observations and large‐scale laboratory experiments show that seismic instability is preceded by slow slip within a finite nucleation zone. In laboratory experiments rupture nucleation is studied mostly using bare (rock) interfaces, whereas upper crustal faults are typically filled with gouge. To investigate effects of gouge on rupture nucleation, we performed a biaxial shearing experiment on a 350 mm long saw‐cut fault filled with gypsum gouge, at room temperature and a minimum horizontal stress σ2 = 0.3–5 MPa. The gouge layer was sandwiched between polymethylmethacrylate (PMMA) plates For reference also a fault without gouge was deformed. Strain gauges and Digital Image Correlation were used to monitor the deformation field along the fault zone margins. Stick‐slip behavior occurred on both the gouge‐filled fault and the PMMA fault. Nucleation of instability on the PMMA fault persistently occurred from one location 2/3 to 3/4 along the fault adjacent to a slow slip zone at the fault end, but nucleation on the gouge‐filled fault was more variable, nucleating at the ends and/or at approximately 2/3 along the fault, with precursory slip occurring over a large fraction of the fault. Nucleation correlated to regions of high average fault stress ratio τ/σn, which was more variable for the gouge‐filled fault due to small length scale variations in normal stress caused by heterogeneous gouge compaction. Rupture velocities and slip rates were lower for the gouge‐filled fault than for the bare PMMA fault. Stick‐slip persisted when σ2 was lowered and the nucleation zone length increased, expanding from the center to the sample ends before transitioning into instability.