Miracle-dz/UniFAR-FTUs huggingface dataset:
CEOR_A_253891 299..306

Elizabeth A Brooks 1 Allison M Singer Dipak R Delvadia 3 David Forstein 4,5 Teresa J Beaudoin Robert L Bauserman Matt W Yuen Carter A Little April Zambelli-Weiner 1 1TTi Health Research & Economics, Westminster, MD, USA; 2Benaroya Research Institute at Virginia Mason Medical Center, Seattle, WA, USA; 3Drexel University College of Medicine, Philadelphia, PA, USA; 4Greenville Health System, Greenville, SC, USA; 5Touro College of Osteopathic Medicine, New York, NY, USA; 6Mercy Clinical Minimally Invasive Gynecology, St. Louis, MO, USA Purpose: The CHOICES study compared short-term resource utilization, facility costs, and perioperative patient outcomes between transcervical fibroid ablation (TFA) with the Sonata® system and myomectomy through a case-matched comparative trial design. This is the first facility-level comparative study conducted for TFA. Patients and Methods: The study enrolled 88 patients from 4 centers equally divided among the two cohorts. The TFA arm consisted of 44 women who had enrolled in the SONATA Pivotal IDE trial, whereas the myomectomy arm included 44 patients who were identified through retrospective case-matching to the enrolled SONATA patients at the same 4 centers. Results: TFA had a significantly lower mean operating room duration (90 minutes) and length of stay (5.2 hours) than myomectomy (143 minutes and 45.8 hours, respectively). The average total mean facility costs for TFA procedure ($7,563) were significantly lower than those associated with myomectomy ($11,425; p=0.002). TFA mean facility costs were also compared with other stratifications of myomectomy (inpatient or outpatient and surgical route). TFA facility costs were significantly lower than that associated with inpatient, abdominal, or laparoscopic myomectomy (all p<0.001). Conclusion: TFA using the Sonata system has a significantly shorter operating room time and length of stay than myomectomy for the treatment of symptomatic uterine fibroids. All procedure, anesthesia, laboratory, pathology, and pharmacy costs were significantly higher for myomectomy as compared to TFA. TFA was also associated with significantly lower facility procedure-related costs compared to myomectomy, including inpatient, abdominal, or laparoscopic myomectomy.
A PILOT STUDY OF EXPRESSIVE BODY MOVEMENT ON AUDIO PARAMETERS OF PIANO PERFORMANCES

Body movement plays an important role in music performances and is widely studied by researchers. However, how the expressive body movement and audio parameters change while trying to maintain consistent musical expressive intentions have not been answered. In this paper, a pilot experiment was designed to explore the objective changes in body movement and audio parameters under three expressive body movement conditions: deadpan, normal, and exaggerated. Through audio and motion data analysis, the results showed that changes in expressive body movement can affect the tempo and dynamics of music. In addition, head movement was the most affected body part under different body movement conditions, but the wrists are hardly affected. Lastly, we proposed that the difficulty of the music may have an impact on the expressive body movement in order to achieve a similar musical expression.
ALK-negative Anaplastic Large-cell Lymphoma (ALCL) is Clinically and Immunophenotypically Different from both ALK-positive ALCL and Peripheral T-cell Lymphoma, Not Otherwise Specified: Report from the International Peripheral T-Cell Lymphoma Project

The International Peripheral T-cell Lymphoma Project is a collaborative effort designed to gain better understanding of peripheral T- and NK/T-cell lymphomas (PTCLs) Twenty-two institutions in North America, Europe and Asia submitted clinical and pathologic information on PTCLs diagnosed and treated at their respective centers. Of the 1314 eligible cases, 181 had anaplastic large cell lymphoma (ALCL) (13.8%) on consensus review: 159 systemic ALCL (12.1%) and 22 primary cutaneous ALCL (1.7%). ALK-positive ALCL patients had a superior outcome compared to those with ALK-negative ALCL (5 year (y) failure-free survival (FFS) 60% vs 36%, p=. 015; 5 y overall survival (OS) 70% vs 49%, p=. 016). However, contrary to prior reports, the 5 y FFS (36% vs 20% p=.012) and OS (49% vs 32% p=.032) was superior for ALK-negative ALCL compared to PTCL, not otherwise specified (PTCL-NOS).
Institutional Knowledge at Singapore Management University Exploring the Role that Forecast Surprise and Forecast Error Play in Determining Management Forecast Precision

The determinants of the precision of the management forecast are important but largely unexplored by prior studies. Using a larger sample of more recent management earnings forecasts than used in prior work, we provide strong evidence that bad news forecasts are less precise than are good news forecasts. In addition, we examine the association between management forecast precision and forecast surprise (i.e., the difference between the management earnings forecast and the market’s extant expectations for future earnings), and between management forecast precision and expected forecast error (i.e., the expected accuracy of the forecast, or the difference between the management earnings forecast and management’s expectations for future earnings). We find that the forecast precision is negatively associated with both forecast surprise and forecast error. Furthermore, we document that the negative association is stronger when the forecast is bad news (i.e., when the forecast is in short of extant market’s expectation) than when it is good news, and when the forecast has negative forecast error (i.e., when forecast exceeds the actual ex post earnings) than when it has positive forecast error, due to greater legal liability concern related to bad news forecasts and negative forecast errors, respectively. Thus, this study enables us to better understand management’s voluntary disclosure incentives and the influence of those incentives on the precision of their forecasts.
21. Effectiveness of Seminar and Webinar in Learning Experience: An Empirical Analysis

The purpose of this study is to analyse the effectiveness of online mode of instruction (webinar) vis-à-vis offline mode of instruction (seminar) and the possible policy implications therein. This Study has been conducted by using the primary data collected from 253 scholars ranging from students to professors through questionnaire. Various factors were taken into consideration for investigation based on review of literature. The results throw light on why scholars favour one mode of learning over the other. This study has repercussions on policy implications concerning effectiveness of distance education involving intergenerational age differences on learning outcome and experience .
The Sensory Processing Dysfunction and Related Postnatal Environmental Factors in Preschool Aged Children in Qingdao, China

Previous studies have shown that prenatal chemical or non-chemical exposure may contribute to the Sensory Processing Dysfunction (SPD). To date, few studies have examined the possible influence of postnatal environmental factors on the SPD. We hypothesized that the postnatal environment in early childhood might also influence the SPD. Parents or guardians of pre-school children completed questionnaires about their postnatal living environment. The sensory processing dysfunction profile was used to measure the possible SPD. Results showed girls invulnerable to the SPD in dyspraxia and visual senses with OR (95% CI) 0.42 (0.30, 0.59) and 0.64 (0.48, 0.86), respectively. Strict or let-alone or not special care style seemed averse to the sensory processing compared to generous care style. Lower frequency of floor vacuuming or cleaning indicated higher risk of SPD in vestibular and tactile sensory. Consistently, child with dirty hands usually showed higher risk of SPD in all 6 sensory except proprioceptive senses. Child living in the home having more furniture in bad materials commonly releasing more volatile or semi-volatile organic compounds indicated higher risk of SPD in vestibular or tactile sensory with OR (95% CI) 1.12 (1.00 – 1.24) and 1.16 (1.04 – 1.30), respectively. Poor gestational nutrition, taken drugs during pregnancy, and gestational passive smoking were also entered the multivariate models and showed adverse association. Our results indicate that a social environment of parental guidance and an indoor environment of exposure to chemical are associated with SPD. Very contribute to grow after the range of 8 years [6]. Harm to the cortex may negatively impact the ability to sensory integration and other types of information. Previous research has indicated that at least 10-Research
Soy Isoﬂavones Exert Antidiabetic and Hypolipidemic Effects through the PPAR Pathways in Obese Zucker Rats and Murine RAW 264.7 Cells 1

The hypocholesterolemic and anti-atherosclerotic mechanism by which soy may exert a beneﬁcial effect remains unclear. Peroxisome-proliferator activated receptors (PPAR) are promiscuous nuclear receptors that regulate the transcription of genes involved in lipid and glucose homeostasis and lipid metabolism within the cell. We hypothesize that the isoﬂavones improve lipid and glucose metabolism by acting as an antidiabetic PPAR agonist. Male and female obese Zucker rats (OZR) were used as a model of Type 2 diabetes, and OZR fed a high isoﬂavone soy protein diet displayed improvements in lipid metabolism consistent with results in humans treated with antidiabetic PPAR agonists such as the ﬁbrates or glitazones. Liver triglyceride and cholesterol concentrations were lower in all OZR fed high-isoﬂavone soy protein diets than in rats fed low-isoﬂavone and casein diets ( P (cid:1) 0.05). Concurrently, PPAR-directed gene expression was evaluated in a cell culture model. An isoﬂavone-containing soy extract doubled PPAR-directed gene expression ( P (cid:1) 0.05) in RAW 264.7 cells containing either a PPAR (cid:1) or PPAR (cid:2) expression plasmid. A similar induction was observed when the soy isoﬂavones genistein or daidzein were used to treat cells. Both isoﬂavones doubled PPAR (cid:1) -directed gene expression ( P (cid:1) 0.05), whereas they increased PPAR (cid:2) -directed gene expression 200–400% ( P (cid:1) 0.05). This study suggests that soy isoﬂavones improve lipid metabolism, produce an antidiabetic effect, and activate PPAR receptors. J. Nutr. 133: 1238–1243, 2003. comparisons (LSD) were made (signiﬁcance at P (cid:5) 0.05) when appropriate. Data are presented as means (cid:4) SEM . For the cell experiments, each time-course experiment was initially analyzed by a two-way ANOVA, and when there were signiﬁcant differences, individual time points were further analyzed post hoc by use of Kruskal– Wallis ANOVA on ranks. All other cell experiments were analyzed by Kruskal–Wallis ANOVA on ranks unless otherwise stated.
Abnormal brain activity in nonsuicidal self-injury: a coordinate-based activation likelihood meta-analysis of functional neuroimaging studies

Background: The high prevalence of nonsuicidal self-injury (NSSI) in youths demonstrates a substantial population-level burden on society. NSSI is often associated with emotional and social skill deficits. To date, several studies have aimed to identify the underlying neural mechanism of those deficits in NSSI by using functional magnetic resonance imaging (fMRI). However, their conclusions display poor consistency. Objective: We aimed to conduct a meta-analysis using activation likelihood estimation (ALE) for fMRI data based on emotional and cognitive tasks to clarify the underlying neural processing deficits of NSSI. Methods: We searched for MRI studies of NSSI in the PubMed, Cochrane, and Embase databases. We identified significant foci for the included studies and conducted two ALE meta-analyses as follows: (i) activation for the NSSI contrast healthy control group and (ii) deactivation for the NSSI contrast healthy controls. Considering the diverse sex composition of study participants and possible bias from one large sample study, we conducted sensitivity analyses for the meta-analysis. Results: Nine studies comprising 359 participants were included, and the results demonstrated substantial activation in NSSI patients compared with healthy controls in two clusters located in the right medial frontal gyrus extending to the rostral anterior cingulate and the left inferior frontal gyrus extending to the insula. Conclusions: The results suggest that individuals with NSSI show brain activity alterations that underpin their core symptoms, including poor emotional regulation and reward processing deficits. Our findings provide new insights into the neural mechanism of NSSI, which may serve as functional biomarkers for developing effective diagnosis and therapeutic interventions for these patients.
AN ANALYSIS ON THE IMPACT OF POPULATION GROWTH ON THE ECONOMY OF NIGERIA

The impact of population growth on the economy has always been a subject of conflict and dishar-mony among economists. Some postulated that population growth could lead to sustainable economic growth; while others asserted that population growth could be detrimental to economic growth. However, population growth in Nigeria put pressure on the economic resources, which leads to low level of productivity and standard of living. The methodology adopted for this study is the regression method using secondary data. The analysis was carried out using the Trend Analysis, Descriptive Stastistics, Ordinary Least Square Augmented Dickey-Fuller (ADF) stationarity test combined with Granger Causality, Error Correction Model and Cointegration tests. The result from the trend analysis shows that the structure of Nigeria population has been increasing steadily since 1994 till 2014. The result from the ordinary least square revealed that there is a positive relationship between economic growth (proxy by GDP per capita),population growth, food production index and human development index; while negative relationships was found between economic growth (proxy by GDP per capita) and fossil fuel energy consumption. The result of the ordinary least square also revealed that population growth is a stimulus to economic growth in Nigeria. The result from the Granger Causality shows that there is a unidirectional relationship between population growth and economic growth. This paper recommends that the average population growth rate of Nigeria should be maintained since it is found to impact positively on economic growth in Nigeria. It recommends that it is important that efforts should be channeled towards growing Nigeria economy, since economic growth causes an increase in population growth. It recommends that population growth should also be taken as a blessing not a curse, since it has long run equilibrium with economic growth. This paper also recommends that the Government should make concerted effort to check population growth rate.
Assessment of some hematological, biochemical parameters and cardiac biomarker levels in patients with ischemic heart disease in Erbil city

The present study was designed to investigate some hematological, biochemical parameters and cardiac biomarker level in male and female patients with ischemic heart disease and healthy person. This study was carried out in the center of heart diseases in Erbil city, one hundred twenty people participated, and sixty of them were suffering from ischemic heart disease (IHD) with both male and female sex in age range 44-72 years. Other sixty healthy people with both sex and same age participate as a control group. The results showed that the white blood cell (WBC)count, increased significantly(P<0.05), hemoglobin (Hb) and packed cell volume (PCV)level, red blood cell (RBC)count, mean corpuscular volume(MCV) and mean corpuscular hemoglobin(MCH) decreased significantly, mean corpuscular hemoglobin concentration(MCHC) decreased nonsignificantly, and platelet count changed nonsignificantly in male patients with IHD when compared with control group. According to biochemical test the level of serum urea, creatinine, cholesterol, triglyceride increased significantly, low-density lipoprotein (LDL), creatine kinase (CK-MB) isoenzyme and troponin- T level increased nonsignificantly and high-density lipoprotein(HDL) level decreased significantly in male patients with IHD when compared with control group. In female patients with IHD, the WBC count increased significantly, Hb concentration, MCV, MCH and MCHC level decreased significantly, in PCV level, RBC count and platelet count no significant changes observed when compared with control group. There was a significant increase in serum urea, creatinine, cholesterol, triglyceride, LDL and creatine kinase(CK-MB) isoenzyme level, and a significant decrease in HDL level, while there was no significant increase in troponin- T level in female patients when compared with control group. In conclusion, a consequence of ischemic heart disease and other risk factors, increment in white blood cells, decrement in blood cellular and alter cardiac biomarker through elevation of CK- MB isoenzyme and Troponin-T in male and female patients was observed.
ATM-dependent DNA damage checkpoint functions regulate gene expression in human fibroblasts

The relationships between profiles of global gene expression and DNA damage checkpoint functions were studied in cells from patients with ataxia telangiectasia (AT). Three telomerase-expressing AT fibroblast lines displayed the expected hypersensitivity to ionizing radiation (IR) and defects in DNA damage checkpoints. Profiles of global gene expression in AT cells were determined at 2, 6 and 24 h after treatment with 1.5 Gy IR or sham-treatment, and were compared to those previously recognized in normal human fibroblasts. Under basal conditions 160 genes or ESTs were differentially expressed in AT and normal fibroblasts, and these were associated by gene ontology with insulin-like growth factor binding and regulation of cell growth. Upon DNA damage, 1091 gene mRNAs were changed in at least two of the three AT cell lines. When compared with the 1811 genes changed in normal human fibroblasts after the same treatment, 715 were found in both AT and normal fibroblasts, including most genes categorized by gene ontology into cell cycle, cell growth and DNA damage response pathways. However, the IR-induced changes in these 715 genes in AT cells usually were delayed or attenuated in comparison to normal cells. The reduced change in DNA-damage-response genes and the attenuated repression of cell-cycle-regulated genes may account for the defects in cell cycle checkpoint function in AT cells.
Coccydynia: A Story Retold

Coccydynia refers to a pathological condition in which pain occurs in the coccyx or its immediate vicinity. The pain is usually provoked by sitting or rising from sitting. Most cases are associated with abnormal mobility of the coccyx, which may trigger a chronic inflammatory process leading to degeneration of this structure. The exact incidence of coccydynia has not been reported; however, factors associated with increased risk of developing coccydynia include obesity and female gender. Several non operative interventions are currently used for the management of coccydynia including Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), hot baths, ring-shaped cushions, intrarectal massage and manipulation (manual therapy), steroid injection, dextrose prolotherapy, ganglion impar blocks, pulsed Radio Frequency Thermocoagulation (RFT) and psychotherapy. Several studies have reported good or excellent results after coccygectomy especially in patients who are refractory to conservative treatment.
O S -S R -N D -H F I SOTOPE E VIDENCE FOR THE A NCIENT D EPLETION AND S UBSEQUENT M -S H ISTORY OF THE K AAPVAAL C RATONIC LITHOSPHERE

The bulk of the Kaapvaal sub-cratonic lithospheric mantle (SCLM) is accepted to have been formed as residua of large degrees of melting in the Archaean and been coupled to the crust ever since. The overall strong major element depletion, however, is not consistent their high relative modal garnet and cpx contents and the enrichment in incompatible trace elements. Numerous models have been proposed to explain these inconsistencies, mostly invoking large-scale metasomatism. However, many open questions remain concerning the style and timing of the processes that led to the modification of the SCLM.We have carried out a detailed, multi-technique study on a suite of low temperature peridotite xenoliths from Kimberley and Lesotho to better constrain these metasomatic processes and to evaluate the timing of growth and relationship between the major modal minerals. Petrography and mineral chemical studies were performed on the samples prior to analysis. Depletion ages of the bulk xenoliths were obtained by Re-Os isotope analyses. Kimberley peridotites yield a range of T RD ages between 1.4 and 2.9 Ga with a tight clustering around 2.7 Ga. Samples from N. Lesotho show evidence of extensive Re metasomatism in recent times, but nevertheless yield Archaean T RD . Major and trace element analyses were carried out on whole rocks with the results showing the typical range of high Mg-numbers, low Al and Ca compositions. Major and trace element traverses were performed across pyroxenes and garnets to evaluate the extent of element zonation. In
AtSig5 Is an Essential Nucleus-Encoded Arabidopsis (cid:1) -Like Factor 1

Transcription of chloroplast genes is subject to control by nucleus-encoded proteins. The chloroplast-encoded RNA polymerase (PEP) is a eubacterial-type RNA polymerase that is presumed to assemble with nucleus-encoded (cid:1) -factors mediating promoter recognition. Recently, families of (cid:1) -factor genes have been identified in several plants including Arabidopsis. One of these genes, Arabidopsis SIG5 , encodes a (cid:1) -factor, AtSig5, which is phylogenetically distinct from the other family members. To investigate the role of this plant (cid:1) -factor, two different insertional alleles of the SIG5 gene were identified and characterized. Heterozygous mutant plants showed no visible leaf phenotype, but exhibited siliques containing aborted embryos and unfertilized ovules. Our inability to recover plants homozygous for a SIG5 gene disruption indicates that SIG5 is an essential gene. SIG5 transcripts accumulate in flower tissues, consistent with a role for AtSig5 protein in reproduction. Therefore, SIG5 encodes an essential member of the Arabidopsis (cid:1) -factor family that plays a role in plant reproduction in addition to its previously proposed role in leaf chloroplast gene expression.