Miracle-dz/UniFAR-FTUs huggingface dataset:
Improving Students’ Moral Logical Thinking and Preventing Violent Acts through Group Counseling in Senior High Schools

This reserach to see the effectiveness of group counseling guideline in enhancing students’ moral logical thinking and preventing violent acts in Senior High Schools in Kota Padang Indonesia. This research applied Research and Development (R&D) method. The results of the research indicate that group counseling guideline is effective to improve students’ moral logical thinking and prevent violent acts among Senior High Schools students in Kota Padang Indonesia.
Magnetized Water and Proline to Boost the Growth, Productivity and Fruit Quality of ‘Taifi’ Pomegranate Subjected to Deficit Irrigation in Saline Clay Soils of Semi-Arid Egypt

Water scarcity is becoming a global problem. The shift from traditional irrigation systems to deficit irrigation increased soil salinity, particularly in clay soils. The use of magnetized water (MW) and biostimulants can induce plant resistance to drought and salinity stress. To assess the role of MW and proline (P) on ‘Taifi’ pomegranate shrubs’ growth, productivity, and fruit quality under such conditions, a split-plots experiment was conducted for two seasons using three irrigation levels (100%, 75%, and 50%), based on the crop water requirements (CWR), and four treatments including foliar spray of tap water (control) and P, irrigation with MW, and MW + P. The most pronounced effect was referred to MW + P at 75% CWR that improved shrubs’ chlorophyll content and nutritional status, reduced endogenous proline content, and enhanced vegetative growth with minimum consumptive water use (CWU), optimum water use efficiency (WUE), maximum water productivity (WP), utmost yield and average fruit weight, lowest percentage of fruit cracking, and fairly good total soluble solids (TSS), vitamin C and anthocyanin contents. Overall, MW + P at 75% CWR improved the resistance mechanism of pomegranate shrubs in saline clay soils, plus improving the growers’ net profit. MW generally reduced soil salinity, expressed as reduced pH, EC, Na+, and Ca2+ values.
Effect of Dictation on Upper Basic Education Students’ English Language Writing Skill in Billiri LGA, Gombe State

This study was on the effects of dictation on upper basic education students’ English language writing skill in Billiri LGA, Gombe state. The study was guided by two research questions and the quasi-experimental research design involving two groups (Dictation and the other Non-Dictation) was used. The population of the study comprised upper basic education students of public Secondary Schools in Billiri LGA from a sample of 127 students from two intact classes selected by the simple random sampling technique to participate in the study. One validated instrument tagged: Upper Basic Education Dictation Writing Skill Test (UBEDWST) with reliability coefficient of 0.81 was used to collect data. The research questions were answered using the mean and standard deviation statistics and computed by the aid of the Statistical Packages for Social Sciences (SPSS version 23). The results obtained showed students exposed to dictation had improved spelling ability and achieved more in writing skill. The study concluded that dictation can positively influence Upper Basic Education Students’ Spelling and writing skill. The study recommended that Upper Basic Education students should be introduced to dictation activities in English language classrooms by their teachers to enhance their spelling ability and texts formation. Also, teachers of English language should make dictation a basic part of their teaching of writing and essay development. The paper recommends that teachers of English language should adopt dictation strategies such as dicto-comp and split dictation by exposing their students to interact and discover ways of constructing different sentences.
Flow Injection Analysis System Coupled to Chronoamperometry and Boron-Doped Diamond Electrode for Determination of Synthetic Hormones 17α-Ethinylestradiol and Cyproterone Acetate

Abstract Flow injection analysis with chronoamperometry detection using a cathodically pretreated boron-doped diamond electrode (CPT-BDDE) was employed to develop and optimize a novel method for the determination of the hormones 17-α-ethinylestradiol (EE2) and cyproterone acetate (CPA). The electrochemical properties of EE2 and CPA were evaluated by cyclic voltammetry and oxidation peaks were observed at 0.97 V and 1.60 V in 0.04 mol L−1 Britton-Robinson buffer (pH 2.0). Analytical curves were linear in the concentration range from 0.070 to 10.0 µmol L−1 for EE2 and 1.0 to 80.0 µmol L−1 for CPA with detection limits of 0.023 and 0.23 µmol L−1, respectively. The developed methods presented good precision and accuracy for EE2 and CPA quantification in commercial pharmaceutical samples. The obtained results were satisfactory and consistent compared with a reference high-performance liquid chromatography method at a confidence level of 95%. Furthermore, recovery studies carried out in synthetic urine and lake water show that these methods do not suffer any significant matrix interferences and are potentially applicable for the determination of these hormones in real samples. Thus, the developed procedure for EE2 and CPA determination are simple and fast, with an analytical frequency of ∼83 determinations per hour, and attractive for routine analysis.
Distribution, Deposition, and Modelling of Lipid and Long-Chain Polyunsaturated Fatty Acids in Atlantic Salmon Fillets

Abstract This review focuses on an understanding of lipid distribution and deposition dynamics in Atlantic salmon and explores the extent to which these can be predicted through multi-dimensional modeling. The methodology used to measure lipids can have an impact on their assessment and considerable work has been done to standardize and develop robust rapid assessment measures. The distribution of lipids in salmon fillets is spatially variable, with levels consistently highest in the belly region and lowest in the tail section. The level of lipids in the whole-body, fillet and Norwegian Quality Cut (NQC) of Atlantic salmon increases with fish size but plateaus as size increases. Lipid levels are predictable based on fish size data although there are various other factors that influence lipid deposition in the fillet. The relationship between these factors and the deposition of n-3 LC-PUFA is mathematically complex but does lend itself to multidimensional modeling. Effects are strongly influenced by dietary fatty acid composition and for the most part a “parity” exists between levels of certain fatty acids in the diet and what ends up in the body tissues. This parity results in a “dilution effect” that generally explains the relationship between diet and whole-body fatty acid levels. Some specific fatty acids demonstrate traits of selective retention in Atlantic salmon muscle tissue. Notably, docosahexaenoic acid is preferentially retained compared to other fatty acids. Which is explained by the understanding that not all fatty acids dilute at the same rate and biologically active fatty acids, like EPA, are essential for mediating inflammatory responses and have a critical role to play in biosynthesis. There are various influential dietary factors in addition to the level of specific fatty acids in the diet, that affect the level of deposition of n-3 LC-PUFA in the muscle.
Therapeutic Role of Vitamin D in Multiple Sclerosis: An Essentially Contested Concept

Multiple sclerosis (MS) is an immune-mediated demyelinating disease of the nervous system with incredibly intricate etiopathogenesis involving numerous genetic, epigenetic, and environmental risk factors. Major environmental risk factors include ultraviolet (UV) radiation, vitamin D, Epstein-Barr virus (EBV) infection, smoking, and high body mass index (BMI). Vitamin D, in particular, can be viewed as one piece of this puzzle, with various tabs and pockets, occupying a sequential site. In this article, we have briefly discussed the neuroimmunology of MS and the role of vitamin D in regulating immune responses. Various observational studies and clinical trials were reviewed and discussed according to stages of disease activity and course of the disease. The data reviewed in this article implied that serum vitamin D levels greatly influence the risk of developing MS and disease activity. Long-term follow-up studies indicated that low serum vitamin D levels correlate with worse disability outcomes. Since clinical trials did not provide significant evidence, the role of vitamin D in controlling disease activity remains unresolved. Larger clinical trials are needed to support the findings of observational studies and provide significant evidence in favour of vitamin D.
Immunotherapy in Advanced Non-Small Cell Lung Cancers: Current Status and Updates

Abstract Non-small-cell lung cancer (NSCLC) is a major health burden, and novel therapeutic options are needed to help solve this problem. One such option is immunotherapy, which targets immune checkpoint molecules that inhibit cancer cells, decreasing immune system activation, for example, immunotherapies target PD-1, its ligand PD-L1, and CTLA-4. There have been major advances in the development of agents that inhibit these molecules, called immune checkpoint inhibitors, and several of them are already approved for usage in NSCLC patients, especially in advanced stages. In this review, the reasons why immune checkpoint inhibitors could be beneficial and the clinical results of studies using these drugs for advanced or recurrent NSCLC patients are discussed, as is the safety profile of the drugs.
The Possible Role of Glucose-6-Phosphate Dehydrogenase in the SARS-CoV-2 Infection

Glucose-6-phosphate dehydrogenase (G6PD) is the second rate-limiting enzyme of the pentose phosphate pathway. This enzyme is present in the cytoplasm of all mammalian cells, and its activity is essential for an adequate functioning of the antioxidant system and for the response of innate immunity. It is responsible for the production of nicotinamide adenine dinucleotide phosphate (NADPH), the first redox equivalent, in the pentose phosphate pathway. Viral infections such as SARS-CoV-2 may induce the Warburg effect with an increase in anaerobic glycolysis and production of lactate. This condition ensures the success of viral replication and production of the virion. Therefore, the activity of G6PD may be increased in COVID-19 patients raising the level of the NADPH, which is needed for the enzymatic and non-enzymatic antioxidant systems that counteract the oxidative stress caused by the cytokine storm. G6PD deficiency affects approximately 350–400 million people worldwide; therefore, it is one of the most prevalent diseases related to enzymatic deficiency worldwide. In G6PD-deficient patients exposed to SARS-CoV-2, the amount of NADPH is reduced, increasing the susceptibility for viral infection. There is loss of the redox homeostasis in them, resulting in severe pneumonia and fatal outcomes.
Modeling Human Cardiac Thin Filament Structures

Striated muscle contraction is regulated in a calcium-dependent manner through dynamic motions of the tropomyosin/troponin polymer, a multicomponent complex wrapped around actin-containing thin filaments. Tropomyosin/troponin sterically blocks myosin-binding at low-calcium concentrations but moves to expose myosin-binding sites at high-calcium concentrations leading to force development. Understanding the key intermolecular interactions that define these dynamic motions will promote our understanding of mutation-induced contractile dysfunction that eventually leads to hypertrophic cardiomyopathy, dilated cardiomyopathy, and skeletal myopathies. Advancements in cryoelectron microscopy (cryoEM) have resulted in a partial elucidation of structures of the thin filament, revealing many atomic-level interactions between the component proteins and critical calcium-dependent conformational alterations. However, building models at the resolutions achieved can be challenging since landmarks in the maps are often missing or ambiguous. Therefore, current computational analyses including de novo structure prediction, protein-protein docking, molecular dynamics flexible fitting, and molecular dynamics simulations are needed to ensure good quality models. We review here our efforts to model the troponin T domain spanning the head-to-tail overlap domain of tropomyosin, improving previous models. Next, we refined the published cryoEM modeled structures, which had mistakenly compressed alpha helices, with a model that has expected helical parameters while matching densities in the cryoEM volume. Lastly, we used this model to reinterpret the interactions between tropomyosin and troponin I showing key features that hold the tropomyosin cable in its low-calcium, sterically blocking position. These revised thin filament models show improved intermolecular interactions in the key low- and high-calcium regulatory states, providing novel insights into function.
Correlation between Sebum Level and Follicular Fluorescence in Acne Vulgaris Patients

Abstract Background: The pathogenesis of acne vulgaris is multifactorial involving four important factors, including follicular epidermal hyperproliferation, increased sebum production, increased activity of C. acnes and inflammation. Increased sebum levels can increase the production of porphyrins which appear as red-orange fluorescence on the faces of patients with acne vulgaris. Objective: To determine the correlation between sebum levels and follicular fluorescence in acne vulgaris patients. Subjects and Methods: This study was an observational analytic study with cross sectional data collection method involving 60 acne vulgaris patients based on inclusion and exclusion criteria. Basic data were recorded including age and gender. Sebum levels were measured using a Sebumeter® SM 815 (C & K, Courage-Khazaka, Cologne, Germany) and follicular fluorescence was examined using a Visiopor® PP34 camera (C & K, Courage-Khazaka, Cologne, Germany). The correlation between sebum levels and follicular fluorescence was analyzed using Spearman correlation. The result was significant if the p value<0.05. Results: Acne vulgaris was more common in women (76.7%) with a mean age of 22.52 years, the youngest was 18 years old and the eldest was 36 years old. The results of this study showed a positive correlation with moderate strength between sebum levels and the spot counts (r = 0.495) and positive correlation with weak strength between sebum levels and the percentage of the area covered with follicular fluorescence spots (r = 0.349). Conclusion: There is a correlation between sebum levels and follicular fluorescence in acne vulgaris patients. Keywords: acne vulgaris, sebum level, follicular fluorescence.
Calibrations and observations with the QUIET radiotelescope

of a dissertation at the University of Miami. Dissertation supervised by Professor Joshua Gundersen. No. of pages in text. (191) The Q/U Imaging ExperimenT (QUIET) is a project aiming to measure the predicted B-mode polarization of the Cosmic Microwave Background (CMB) radiation and improve the characterization of the E-mode component. The CMB was generated 380,000 years after the Big Bang during a period known as recombination, once the universe had expanded enough to cool to a temperature of 3,600 K. This relic radiation provides crucial information about the large-scale physical conditions and processes prevailing up to and during that period. The prediction of B-mode polarization arises from cosmological models in which the universe underwent an inflationary phase that occurred 10−35 s after the Big Bang, and lasted 10−32 s. Inflation propagated original quantum fluctuations in space-time to the post-inflationary period in the form of gravitational waves, which produced ripples in space and polarization of the CMB in the form of Eand B-mode patterns. Scalar density perturbations were also propagated by the inflation but derived in the formation of E-modes only. The detection of B-mode polarization would thus provide strong support to the inflationary scenario that considers the existence of primordial gravitational waves. The expected level of this signal is ∼ 10−8 K and its measurement represents an enormous scientific and technical challenge. The QUIET telescope observed the microwave sky with two arrays of polarimeters operating at 43 and 94 GHz. It was located in the Chilean Andes and collected more than 10,000 hours of data between October 2008 and December 2010. The detector elements are based on state-of-the-art Monolithic Microwave Integrated Circuit (MMIC) technology and were designed to provide simultaneous measurements of the Q and U Stokes parameters of the sky, improving the efficiency and sensitivity of the instrument. This thesis describes the design of the QUIET telescope, the observations conducted, and the results of the data analysis. The attention is centered on the analysis of calibration data gathered through the observation of astronomical sources such as the Crab nebula and Jupiter in order to characterize the telescope beam patterns, responsivities and instrumental polarization. Finally, the impact of these quantities and their uncertainties on the CMB results is addressed. To God, my family, and all those that have been with me along the way.
Rule Extraction for Screening of COVID-19 Disease Using Granular Computing Approach

In the epidemic status of an unknown virus called Coronavirus, one of the main problems is inadequate access to treatment centers. Statistics show that many people are infected with the virus through unseasonable visits to medical centers immediately after noticing the initial symptoms similar to those reported for Coronavirus. Besides, unnecessary congestion at health centers reduces the quality of service to patients in urgent need of care. Since any external factor, including the virus, appears to have some symptoms after the onset of activity in the affected person, early diagnosis is possible. This paper presents an approach to classifying patients and diagnosing disease by symptoms, based on granular computing. One of the vital features of this method is the extraction of correct rules with zero entropy. This process is done based on a predefined classification of training datasets collected by experts. Granular computing has been a helpful approach in rule extraction and variety in recent years. Experimental results show that the proposed method can successfully detect COVID-19 disease according to its observed symptoms.
A Case Study of Co-production Within a Mental Health Recovery College Dementia Course: Perspectives of A Person With Dementia, Their Family Supporter and Mental Health Staff

Background Undertaking co-production as a power-sharing way to improve mental health dementia services remains uncommon, suggesting opportunities to apply knowledge from lived experience of people with dementia, may often be missed. One barrier is stigma, assuming people with progressive cognitive impairment cannot manage this level of participation, support peers nor offer a “valid” perspective. Purpose This paper shares knowledge gained from a service evaluation that explored various experiences of a person with dementia, their family supporter and mental health staff, involved in co-producing a course about “living well” with dementia, within a mental health Recovery College. Design A qualitative, case study approach used semi-structured interviewing and inductive thematic analysis. Findings Co-production activities generated a shared sense of positivity, pride and privilege, highlighting positive effects in breaking down the “them and us” barriers common in traditional healthcare professional-service user relationships. Each individual had both something to offer and something to gain during the process. Staff identified challenges in the co-production process; in that balancing all the voices during meetings could be complex at times, and the process overall required considerable time commitment. Conclusion Taking part in co-production at an appropriate level and with peer support is a relational activity seen to be valuable in powerfully, yet gently, challenging stigma and assumptions around dementia. Findings show that while the process of co-production requires time and dedication, there is overall value in involving people living with dementia both in co-production and in peer support. This provided a straightforward and beneficial means to inclusively improve post-diagnosis support and care quality within a memory service.
Successful Treatment of Refractory Anemia in a Patient With Glycogen Storage Disease Type Ia Undergoing Hemodialysis

Glycogen storage disease type Ⅰa (GSDIa), also known as von Gierke disease, is a rare inherited metabolic disorder caused by defective glucose 6-phosphatase (G6Pase) activity. Although anemia, renal failure, and hepatic adenoma are the major clinical manifestations of GSDIa, there has been no report of refractory anemia in GSDIa patients on maintenance hemodialysis (HD) concomitant with multiple liver adenomas. Herein, we present a case of refractory anemia in a patient with GSDIa undergoing HD with multiple hepatic adenomas, successfully managed through aggressive treatment for renal anemia and intravenous iron therapy (IIT). A 26-year-old man with GSDIa who had been on HD for a year suffered from refractory anemia. He had experienced hypoglycemia and hyperlactic acidemia repeatedly and unusual hypertriglyceridemia had been observed for a long time. In addition, multiple hepatic adenomas developed and his renal function gradually declined, eventually progressing to end-stage kidney disease, and HD was started. Despite 120 µg/week of darbepoetin alfa (DA), 200 mg/day of oral sodium ferrous citrate, and 600 mg/week of roxadustat, the anemia persisted and iron deficiency gradually progressed. We considered that renal anemia, blood loss by each HD session, and decreased intestinal iron absorption due to inappropriately increased hepcidin from hepatic adenomas were the main etiology of the anemia; hence, we changed oral sodium ferrous citrate to intravenous saccharated ferric oxide along with continuous aggressive treatment of renal anemia, and the anemia resolved quickly within three months. We believe that refractory anemia was mainly induced by renal anemia and chronic iron deficiency due to blood loss during HD and inappropriately elevated hepcidin levels in hepatic adenomas. Aggressive treatment of renal anemia, along with IIT, may be a promising treatment option. Strict monitoring of iron overload is essential for safe treatment.