Miracle-dz/UniFAR-FTUs huggingface dataset:
Investigating the Diurnal Radiative, Turbulent, and Biophysical Processes in the Amazonian Canopy‐Atmosphere Interface by Combining LES Simulations and Observations

We investigate the atmospheric diurnal variability inside and above the Amazonian rainforest for a representative day during the dry season. To this end, we combine high‐resolution large‐eddy simulations that are constrained and evaluated against a comprehensive observation set, including CO2 concentrations, gathered during GoAmazon2014/15. We design systematic numerical experiments to quantify whether a multilayer approach in solving the explicit canopy improves our canopy‐atmosphere representation. We particularly focus on the relationship between photosynthesis and plant transpiration, and their distribution at leaf and canopy scales. We found the variability of photosynthesis drivers like vapor pressure deficit and leaf temperature to be about 3 times larger for sunlit leaves compared to shaded leaves. This leads to a large spread on leaf stomatal conductance values with minimum and maximum values varying more than 100%. Regarding the turbulent structure, we find wind‐driven stripe‐like shapes at the canopy top and structures resembling convective cells at the canopy. Wind‐related variables provide the best spatiotemporal agreement between model and observations. The potential temperature and heat flux profiles agree with an observed decoupling near the canopy top interface, although with less variability and cold biases of up to 3 K. The increasing complexity on the biophysical processes leads to the largest disagreements for evaporation, CO2 plant assimilation and soil efflux. The model is able to capture the correct dependences and trends with the magnitudes still differing. We finally discuss the need to revise leaf and soil models and to complete the observations at leaf and canopy levels.
Reversible one-dimensional cellular automata with one of the two Welch indices equal to 1 and full shifts

Reversible cellular automata are invertible discrete dynamical systems which have been widely studied both for analysing interesting theoretical questions and for obtaining relevant practical applications, for instance, simulating invertible natural systems or implementing data coding devices. An important problem in the theory of reversible automata is to know how the local behaviour which is not invertible is able to yield a reversible global one. In this sense, symbolic dynamics plays an important role for obtaining an adequate representation of a reversible cellular automaton. In this paper we prove the equivalence between a reversible automaton where the ancestors only differ at one side (technically with one of the two Welch indices equal to 1) and a full shift. We represent any reversible automaton by a de Bruijn diagram, and we characterize the way in which the diagram produces an evolution formed by undefined repetitions of two states. By means of amalgamations, we prove that there is always a way of transforming a de Bruijn diagram into the full shift. Finally, we provide an example illustrating the previous results.
Supply Chain Management Practice and Its Impact on Performance of Humanitarian Relief Organization in Case of Gedeo Zone

Abstract: Purpose: The purpose of this study was to see how supply chain management practices affected humanitarian relief organizations in the Gedeo zone. Research methodology: The study used a mixed research approach, with respondents selected using a stratified proportionate technique from each organization's employees to disseminate a questionnaire and semi-structured interviews done using a purposeful sampling technique. Correlation and regression, as well as thematic analysis, were used in the analysis. Results: The finding of the study reveals that supplier integration, information sharing, postponement, and outsourcing affect humanitarian relief organizations’ performance positively in a statistically significant way. Limitations: The main limitation is that the study focused only on humanitarian relief organizations operating in the Gedeo zone. Contribution: Ethiopia experienced natural and human-made disasters such as (El Niño, flood, famine, war, communal conflict, etc) for decades. To reduce the threat of this, the Study suggests that supply chain management practice is a serious concern for many relief humanitarian organizations operating in the Gedeo zone. Keywords: 1. supply chain management practice 2. humanitarian relief 3. organization performance
Generalizations to several variables of Lagrange's expansion, with applications to stochastic processes

ABSTRACT A generalization to two independent variables of Lagrange's expansion of an inverse function was given by Stieltjes and proved rigorously by Poincaré. A new method of proof is given here that also provides a new and sometimes more convenient form of the generalization. The results are given for an arbitrary number of independent variables. Applications are pointed out to random branching processes, to queues with various types of customers, and to some enumeration problems.
Aglianico Grape Seed Semi-Polar Extract Exerts Anticancer Effects by Modulating MDM2 Expression and Metabolic Pathways

Grapevine (Vitis vinifera L.) seeds are rich in polyphenols including proanthocyanidins, molecules with a variety of biological effects including anticancer action. We have previously reported that the grape seed semi-polar extract of Aglianico cultivar (AGS) was able to induce apoptosis and decrease cancer properties in different mesothelioma cell lines. Concomitantly, this extract resulted in enriched oligomeric proanthocyanidins which might be involved in determining the anticancer activity. Through transcriptomic and metabolomic analyses, we investigated in detail the anticancer pathway induced by AGS. Transcriptomics analysis and functional annotation allowed the identification of the relevant causative genes involved in the apoptotic induction following AGS treatment. Subsequent biological validation strengthened the hypothesis that MDM2 could be the molecular target of AGS and that it could act in both a p53-dependent and independent manner. Finally, AGS significantly inhibited tumor progression in a xenograft mouse model of mesothelioma, confirming also in vivo that MDM2 could act as molecular player responsible for the AGS antitumor effect. Our findings indicated that AGS, exerting a pro-apoptotic effect by hindering MDM2 pathway, could represent a novel source of anticancer molecules.
Advances and Challenges in Diagnostics of Toxoplasmosis in HIV-Infected Patients

Toxoplasma gondii is a worldwide distributed protozoan parasite. This apicomplexan parasite infects one-third of the population worldwide, causing toxoplasmosis, considered one of the neglected parasitic infections. In healthy humans, most infections are asymptomatic. However, in immunocompromised patients, the course of the disease can be life-threatening. Human immunodeficiency virus (HIV)-infected patients have a very high burden of Toxoplasma gondii co-infection. Thus, it is essential to use modern, sensitive, and specific methods to properly monitor the course of toxoplasmosis in immunodeficient patients.
Psychometric Evaluation of the Arabic Version of the Person-Centered Climate Questionnaire: Patient Version (PCQ-P)

Background: Adopting a person-centered care approach has transformed different healthcare settings worldwide. However, this concept has gained little attention in many Middle Eastern countries, including Saudi Arabia and other Arab countries. This study aimed to evaluate the psychometric characteristics of the Arabic person-centered climate questionnaire—patient version, measuring to what extent the climate of health care settings is perceived as being person-centered. Method: This is a psychometric analysis study. The original validated version of the English Person-Centered Climate Questionnaire—Patient version (PCQ-P) was translated into Arabic and tested among a sample of hospital patients (n = 300) in Saudi Arabia using translation and back translation procedures. For psychometric evaluation, statistical analyses of validity and reliability were used, including exploratory factor analysis as well as conformity analysis. Results: The Arabic version of the person-centered climate questionnaire—patient version—showed good reliability as the Cronbach’s alpha value of the total of 17 items was 0.84, and the Cronbach’s alpha values of the three sub-scales (safety, everydayness, and hospitality) were 0.83, 0.56, and 0.68, respectively. Internal consistency results were high in terms cof orrelation coefficient for all 17 items. The exploratory factor analysis identified the three factors (safety, everydayness, and hospitality) responsible for 47.174% of the total variance. Conclusion: The Arabic version of the PCQ-P showed satisfactory reliability and validity for measuring patients’ perceptions of person-centeredness in Arab healthcare settings. This Arabic version will be accessible to those interested in generating and using empirical evidence to promote a patient-centered care approach in Arab healthcare settings. The results of this study can be used as a starting point for assessing and developing a person-centered care culture in Saudi hospitals and other Arab countries in the Middle East.
On the nonlinear evolution of columnar vortices in a rotating environment

We examine the three-dimensional, nonlinear evolution of columnar vortices in a rotating environment. As the initial vorticity distribution, a wavetrain of finite amplitude Kelvin-Helmholtz vortices in shear is employed. Through direct numerical simulation of the Navier-Stokes equations we seek to better understand the process of maturation of the various three-dimensional modes of instability to which such vortical flows are subject, especially those which exist as a consequence of the action of the Coriolis force. In the absence of rotational influence, we thereby demonstrate that the nonlinear evolution of columnar vortices is most strongly controlled by one or the other of two mechanisms. One mechanism of instability is identifiable as a so-called elliptical instability, which promotes the initial bending of vortex tubes in a sinusoidal fashion, while the other is a hyperbolic mode, which is responsible for the development of streamwise vortex streaks in the "braids" between adjacent vortex cores. In the rotating case, anticyclonic vortices are strongly destabilized by weak background rotation, while rapid rotation stabilizes both the cyclones and anticyclones. The strong anticyclones are subject to two distinct forms of instability, namely a Coriolis force modified elliptical instability and an inertial (centrifugal) instability. The former instability is very similar to the nonrotating form of the elliptical instability as it promotes bending of vortex tubes, while the latter instability grows on the edge of the vortex core and generates streaks of vorticity, which surround the vortex core itself. These results of direct numerical simulation fully verify the results of previous linear stability analyses. Taken together, they provide a simple explanation for the broken symmetry that is often observed to be characteristic of the von Karman vortex streets that develop in the atmospheric lee of oceanic islands.
Analysis of mode separation in multichannel branching waveguides

Spatial separation of modes is important in multiport switching and wavelength multiplexing for integrated optics, and in controlling the spatial modes in multimode semiconductor laser structures. It has been recently shown that the m normal modes of an m - mode channel waveguide can be separated by branching into m single-mode channels whose propagation constants are all different. By means of examples, we answer two questions about this mode separation scheme. 1) How widely separated must the channels be in order for each mode to be concentrated in a different one of the channels? 2) How small must the branching angle be in order for the power to remain in the launched mode? The effects of wavelength, dimensions, and refractive index step are discussed. Important conclusions are that the branching angle must be rather small, of the order of a few milliradians, and that it is helpful to have the largest possible difference in the widths of the guiding channels, thereby giving them the largest possible difference in uncoupled propagation constants.
Capacity Estimation of Lithium-Ion Batteries Based on Multiple Small Voltage Sections and BP Neural Networks

Accurate capacity estimation of onboard lithium-ion batteries is crucial to the performance and safety of electric vehicles. In recent years, data-driven methods based on partial charging curve have been widely studied due to their low requirement of battery knowledge and easy implementation. However, existing data-driven methods are usually based on a fixed voltage segment or state of charge, which would be failed if the charging process does not cover the predetermined segment due to the user’s free charging behavior. This paper proposes a capacity estimation method using multiple small voltage sections and back propagation neural networks. It is intended to reduce the requirement of the length of voltage segment for estimating the complete battery capacity in an incomplete charging cycle. Firstly, the voltage segment most possibly covered is selected and divided into a number of small sections. Then, sectional capacity and skewness of the voltage curve are extracted from these small voltage sections, and severed as health factors. Secondly, the Box–Cox transformation is adopted to enhance the correlation between health factors and the capacity. Thirdly, multiple back propagation neural networks are constructed to achieve capacity estimation based on each voltage section, and their weighted average is taken as the final result. Finally, two public datasets are employed to verify the accuracy and generalization of the proposed method. Results show that the root mean square error of the fusion estimation is lower than 4.5%.
Diode-Laser Spectroscopy: Line Profiles of H2O in the Region of 1.39 μm

Abstract Using a stabilized diode-laser spectrometer, we have studied the line profiles of water vapor near 7185.59 cm −1 . With low pressures of pure gas (≤1,Torr) in a White-type cell, we have deduced the line intensities using the Voigt profile. This study shows clear differences between experimental and calculated lines described by a Voigt profile when the pressure increases. For water vapor in mixtures with N 2 , O 2 , Ar, or He, we have determined the collisional broadening coefficients, taking into account the collisional narrowing (Dicke effect). The narrowing parameters have been determined using soft (Galatry) or hard (Rautian and Sobel'man) collision models and compared to the dynamic friction coefficient.
Evidence for substructure in rich clusters of galaxies from radial-velocity measurements

New radial-velocity measurements in 15 clusters of galaxies are used to look for substructure. With a new statistical test that looks for deviations of the local velocity mean and dispersion from the global values, it is found that most of the clusters in the sample show significant subclustering. In 30-40 percent of the cases, the subclusters contain a large fraction of the galaxies found in the main body of the cluster. This result is in good agreement with earlier work by Geller and Beers (1982) based on number counts. The large fraction of clusters with significant substructure, along with evidence based on radial-velocity dispersion profiles, suggest that many, perhaps most, rich clusters did not collapse in single, coherent events. 22 references.
Combined tazemetostat and MAPKi enhances differentiation of papillary thyroid cancer cells harbouring BRAF V600E by synergistically decreasing global trimethylation of H3K27

Clinical efficacy of differentiation therapy with mitogen‐activated protein kinase inhibitors (MAPKi) for lethal radioiodine‐refractory papillary thyroid cancer (RR‐PTC) urgently needs to be improved and the aberrant trimethylation of histone H3 lysine 27 (H3K27) plays a vital role in BRAFV600E‐MAPK‐induced cancer dedifferentiation and drug resistance. Therefore, dual inhibition of MAPK and histone methyltransferase (EZH2) may produce more favourable treatment effects. In this study, BRAFV600E‐mutant (BCPAP and K1) and BRAF‐wild‐type (TPC‐1) PTC cells were treated with MAPKi (dabrafenib or selumetinib) or EZH2 inhibitor (tazemetostat), or in combination, and the expression of iodine‐metabolizing genes, radioiodine uptake, and toxicity were tested. We found that tazemetostat alone slightly increased iodine‐metabolizing gene expression and promoted radioiodine uptake and toxicity, irrespective of the BRAF status. However, MAPKi induced these effects preferentially in BRAFV600E mutant cells, which was robustly strengthened by tazemetostat incorporation. Mechanically, MAPKi‐induced decrease of trimethylation of H3K27 was evidently intensified by tazemetostat in BRAFV600E‐mutant cells. In conclusion, tazemetostat combined with MAPKi enhances differentiation of PTC cells harbouring BRAFV600E through synergistically decreasing global trimethylation of H3K27, representing a novel differentiation strategy.
IMF By effects in the magnetospheric convection on closed magnetic field lines

Using data from the Super Dual Auroral Radar Network (SuperDARN) and the ultraviolet imager on the Polar satellite, we have earlier shown that the IMF By‐related electric field can penetrate into the closed magnetosphere and produce convection changes in the region of the postnoon auroral oval [ Kozlovsky et al., JGR, N12, 2002 ]. In such a case, contra‐directed azimuthal (East–West) plasma flows should be expected in the conjugated hemispheres. In this paper we present a theoretical model, which can well explain these observations. Due to the solar wind‐magnetosphere dynamo, IMF By generates a voltage between the two polar caps, so that field‐aligned currents flow between the two hemispheres within some layer just equatorward of the open polar cap boundary. In this region a field‐aligned potential difference (i.e., a magnetic field line discontinuity) can occur when the field‐aligned current exceeds a threshold value. The IMF By‐related contra‐directed ionospheric plasma flows can co‐exist in the northern and southern hemispheres within the region of the inter‐hemispheric field‐aligned currents. The latitudinal width of this region depends on the IMF By and the ionospheric conductance, and can be of the order of 1–2 degrees.
On certain varieties of groups which are central extensions

Abstract Connexions are sought between the subvarieties of a variety U of groups and the subvarieties of the variety of all groups which are central extensions by groups in U, in the case when U has the form . Here , is the variety of abelian groups of exponent dividing r and Bis a variety of soluble groups of finite exponent.
The Weak s-Component and Nucleosynthesis in Massive Stars

The difficulties of the phenomenological analysis of the weak s-component and the need for a comparison with the astrophysical picture are discussed. New results of s-process calculations in massive stars during both core He and shell C burning are presented. They are obtained after adopting an updated nuclear network, which includes the deviation from the 1/v trends of neutron capture cross sections, as well as an extrapolation of beta decay rates to the high temperatures characterizing carbon burning. For a complete discussion of the branching at 85 Kr, we additionally present a new measurement of the 87 Rb neutron capture cross section
Progresses, Challenges, and Prospects of CRISPR/Cas9 Gene-Editing in Glioma Studies

Simple Summary Glioma is the most common primary intracranial tumor.Glioma involves a wide variety of cells and is highly aggressive, so most patients with glioblastoma have a poor prognosis.Glioma involves a wide variety of cells and is highly aggressive, so most patients with glioblastoma have a poor prognosis. CRISPR/Cas9 has the property of precise localization, and more and more studies focus on using it for the treatment of glioma and the exploration of its pathogenesis.This paper mainly discusses the role of CRISPR/Cas9 in the treatment of glioma patients, screening of key targets for clinical prognosis, and exploring the pathogenesis of glioma.The future research prospects of CRISPR/Cas9 in glioma treatment and potential opportunities and challenges are also pointed out. In order to help readers comprehensively understand the application and development of CRISPR/Cas9 in glioma research. Abstract Glioma refers to a tumor that is derived from brain glial stem cells or progenitor cells and is the most common primary intracranial tumor. Due to its complex cellular components, as well as the aggressiveness and specificity of the pathogenic site of glioma, most patients with malignant glioma have poor prognoses following surgeries, radiotherapies, and chemotherapies. In recent years, an increasing amount of research has focused on the use of CRISPR/Cas9 gene-editing technology in the treatment of glioma. As an emerging gene-editing technology, CRISPR/Cas9 utilizes the expression of certain functional proteins to repair tissues or treat gene-deficient diseases and could be applied to immunotherapies through the expression of antigens, antibodies, or receptors. In addition, some research also utilized CRISPR/Cas9 to establish tumor models so as to study tumor pathogenesis and screen tumor prognostic targets. This paper mainly discusses the roles of CRISPR/Cas9 in the treatment of glioma patients, the exploration of the pathogenesis of neuroglioma, and the screening targets for clinical prognosis. This paper also raises the future research prospects of CRISPR/Cas9 in glioma, as well as the opportunities and challenges that it will face in clinical treatment in the future.
Ångström (B1Σ+ →A1Π) 0–1 and 1–1 bands in isotopic CO molecules: further investigations

In the emission spectrum of six 12C16O, 13C16O, 12C18O, 14C16O, 13C18O and 14C18O isotopologues of the carbon monoxide molecule, new recordings and analyses or new reanalyses of the selected and strongest bands belonging to the Ångström (B1Σ+ − A1Π) system were carried out. Under high resolution, emission spectra of the 0–1 and 1–1 bands were recorded and reanalysed, representing both the 0 − v″ and 1 − v″ progressions of this system. Unobserved so far, new spectral lines were identified, and for the 12C16O, 13C16O, 12C18O, 14C16O and 14C18O molecules new parameters of the rovibronic structure B0, B1, D0 and D1 of the v = 0 and v = 1 levels of the B1Σ+ state and band origins ν0 of the 0–1 and 1–1 bands of the B − A transition were determined. A detailed analysis included the predissociation regions of the spectra observed in all analysed bands and isotopologues. The values of rotational quantum numbers and rovibronic terms of the highest nonpredissociated Jh as well as the first, already predissociated Jf levels were determined. On that basis, a new and more precise value of dissociation energy of the CO molecule was determined: De=(90679.1±6.0)? > cm−1. Also, atomic states of the dissociation products of this molecule, which correspond to this energy, were identified as C(3P0) + O(3P2) i.e. as both triplet ground atomic sublevels.
Electron-ion recombination measurements in the flowing afterglow

Electron-ion recombination rates (T approximately=300 K) have been measured in a flowing afterglow tube, using an axially traversable ion sampling mass spectrometer and floating double probe. The values are O2+:1.9+or-0.5*10-7 cm3 s-1, N2+:2.2+or-0.4*10-7 cm3 s-1, NO+:3.4+or-0.6*10-7 cm3 s-1, and CO2+:3.4+or-1.2*10-7 cm3 s-1.