Miracle-dz/UniFAR-FTUs huggingface dataset:
Recent Advances in Light-Controlled Activation of Pt(IV) Prodrugs

Pt(IV) prodrugs remain one of the most promising alternatives to conventional Pt(II) therapy due to their versatility in axial ligand choice and delayed mode of action. Selective activation from an external source is especially attractive due to the opportunity to control the activity of an antitumor drug in space and time and avoid damage to normal tissues. In this review, we discuss recent advances in photoabsorber-mediated photocontrollable activation of Pt(IV) prodrugs. Two main approaches developed are the focus of the review. The first one is the photocatalytic strategy based on the flavin derivatives that are not covalently bound to the Pt(IV) substrate. The second one is the conjugation of photoactive molecules with the Pt(II) drug via axial position, yielding dual-action Pt(IV) molecules capable of the controllable release of Pt(II) cytotoxic agents. Thus, Pt(IV) prodrugs with a light-controlled mode of activation are non-toxic in the absence of light, but show high antiproliferative activity when irradiated. The susceptibility of Pt(IV) prodrugs to photoreduction, photoactivation mechanisms, and biological activity is considered in this review.
Crossover distributions at the edge of the rarefaction fan

We consider the weakly asymmetric limit of simple exclusion process with drift to the left, starting from step Bernoulli initial data with $\rho_-<\rho_+$ so that macroscopically one has a rarefaction fan. We study the fluctuations of the process observed along slopes in the fan, which are given by the Hopf--Cole solution of the Kardar-Parisi-Zhang (KPZ) equation, with appropriate initial data. For slopes strictly inside the fan, the initial data is a Dirac delta function and the one point distribution functions have been computed in [Comm. Pure Appl. Math. 64 (2011) 466-537] and [Nuclear Phys. B 834 (2010) 523-542]. At the edge of the rarefaction fan, the initial data is one-sided Brownian. We obtain a new family of crossover distributions giving the exact one-point distributions of this process, which converge, as $T\nearrow\infty$ to those of the Airy $\mathcal{A}_{2\to \mathrm{BM}}$ process. As an application, we prove moment and large deviation estimates for the equilibrium Hopf-Cole solution of KPZ. These bounds rely on the apparently new observation that the FKG inequality holds for the stochastic heat equation. Finally, via a Feynman-Kac path integral, the KPZ equation also governs the free energy of the continuum directed polymer, and thus our formula may also be interpreted in those terms.
A Brunn-Minkowski type inequality for Fano manifolds and the Bando-Mabuchi uniqueness theorem

For $\phi$ a metric on the anticanonical bundle, $-K_X$, of a Fano manifold $X$ we consider the volume of $X$ $$ \int_X e^{-\phi}. $$ We prove that the logarithm of the volume is concave along continuous geodesics in the space of positively curved metrics on $-K_X$ and that the concavity is strict unless the geodesic comes from the flow of a holomorphic vector field on $X$. As consequences we get a simplified proof of the Bando-Mabuchi uniqueness theorem for K\"ahler - Einstein metrics and a generalization of this theorem to 'twisted' K\"ahler-Einstein metrics.
Value Creation and Value Appropriation

This article discusses the nine research studies compiled for the Journal of Creating Value (JCV) special issue, which has embarked on securing a deeper understanding of the divergent aspects of defining, measuring and maximizing value. Altogether, the nine studies collectively offer insights in this regard that are applicable to a wide range of organizations. This special issue runs the gamut of management actions in terms of value management and prepares companies for the future. The proposed classification framework in this article categorizes the nine studies based on their focus on value creation potential and value appropriation potential. Further, this article identifies and delineates future research directions that extend beyond the path forward identified by each of the studies themselves. Overall, this article is aimed to serve as a guide to understand and appreciate this special issue on a topic of vital interest.
Nonlinear Utility and the Probability Score

Abstract Proper scoring rules, such as the probability score, are based (in part) upon the assumption that the assessor's utility function is linearly related to the score. The effects of two nonlinear utility functions, one representing a “risk-taker” and one representing a “risk-avoider,” on an assessor's probability forecasts are considered. The results indicate that factors other than the expected score, e.g., the variance of the score, may be relevant for probability assessment. In general, a “risk-taker” “hedges” toward a categorical forecast, while a “risk-avoider” “hedges” away from a categorical forecast. The implications of these results for the process of probability assessment are briefly discussed.
Virtual homology of surgered torus bundles

Let $M$ be a once-punctured torus bundle over $S^1$ with monodromy $h$. We show that, under certain hypotheses on $h$, "most" Dehn-fillings of $M$ (in some cases all but finitely many) are virtually $\mathbb{Z}$-representable. We apply our results to show that surgeries on the figure-eight knot with even numerator are virtually $\mathbb{Z}$-representable.
Pseudo-Differential Operators and Markov Processes

Markov processes and pseudo-dofferential operators - why? Levy processes and continuous negative definite functions pseudo-differential operators and Dirichlet forms constructing Feller semi-groups from pseudo-differential operators the martingale problem for pseudo-differential operators subordination in the sense of Bochner transition functions (existence, estimates) path properties and symbol Balayage theory and the Dirichlet problem for pseudo-differential operators.
Barrier height determination of SiC Schottky diodes by capacitance and current-voltage measurements

Extractions of barrier heights of 6H and 4H-SiC Schottky diodes have been performed on structures with various gate metallization, using both capacitance-voltage (C-V) and current-voltage (I-V) measurements. The sum of the two barriers extracted by C-V measurements on both n-type and p-type materials is found to be higher than the band gap energy E-G, whereas the one extracted by I-V is less than E-G. However, above room temperature, temperature variations of barrier heights are in agreement with the variations of E-G. We have also computed theoretical I-V characteristics using a two-barrier height model. By taking account of temperature variations of a large number of parameters, e.g., the carrier mobility, free carrier concentration, and barrier height, we have achieved a good fit with experimental data. The model is shown to be valid for n-type Schottky diodes over a wide range of temperatures (from 100 to 500 K).
Public Attitudes Toward Immigration: Was There a Trump Effect?

This paper examines public opinion about immigration policy in 2012 and 2016, seeking to understand whether there are meaningful differences in public opinion across these elections, whether the predictors of opinion changed, and whether the issue’s salience grew. One prominent candidate for explaining differences in opinion about immigration in 2016 is the rhetoric of Donald J. Trump, whose presidential candidacy was launched with an attack on immigration from Mexico. We analyze content from Trump’s campaign speeches and from Mitt Romney’s 2012 campaign speeches to compare the emphasis on immigration themes, finding that Trump talked far more about immigration than Romney did. We also examine media coverage and find a marked increase in mentions of the immigration issue, which should, in theory, lead to more people seeing immigration as an important problem. We analyze “most important problem” questions from American National Election Studies surveys and find that mentions of immigration increased from less than one percent in 2012 to about five percent in 2016. However, we find that the overall distribution of public opinion about immigration changed very little from 2012 to 2016. Multivariate models show that the predictors of opinion about immigration policies were primarily the same in 2016 as in 2012: a combination of perceived economic threat, perceived cultural threat, and ethnic prejudice. In addition, models of presidential vote choice find that immigration issues were statistically significant predictors in 2016 but not in 2012. All of this suggests that Trump’s 2016 candidacy did not persuade so much as it activated. Trump’s rhetoric did not significantly alter American public opinion on immigration. Still, his emphasis on the immigration issue did garner increased media coverage and was attractive to many Republican and conservative voters who already held anti-immigration views.
Development of natural coir/jute fibers hybrid composite materials for automotive thermal insulation applications

Thermal comfort property is closely related to the concept of thermal insulation and includes protection against heat. This research paper presents an experimental study on thermal insulation properties, for natural fiber composite materials: a natural fiber (Coir/Jute) with different blend proportions of raw materials mixed with rigid polyurethane foam as a binder. The natural fiber composite materials were characterized by both thermal resistance (Thermal Insulation Value TIV) and also in terms of heat transfer (thermal conductivity). Thermal insulation values were measured according to Lee’s disk method (ASTM C177). The influence of the structure of these materials on the thermal insulating properties was analyzed. The experimental results show the thermal resistance performances of natural fiber composites based on coir/jute fiber materials, thus promoting environmentally friendly solutions.
Optimizing parameter for electrophoretic deposition of hydroxyapatite coating with superior corrosion resistance on pure titanium

Bioactive hydroxyapatite (HA) coating is applied on a commercially pure Ti by electrophoretic deposition (EPD). Optimizing the coating structure is necessary to obtain a stable layer and the best corrosion protection. The EPD was conducted at a constant voltage of 20, 30, and 40 V for 30 min in a HA/DMF (dimethylformamide) suspension. Uniform HA layers with a Ca/P ratio of 1.82 were successfully deposited on the Ti surface. The layers, which consisted of HA grains with the size of 1–5 μm, exhibited a gradual increase in thickness of 32, 50, and 60 μm with formation voltage. For the biomedical application, the suitable coating thickness was at least 50 μm. The high compaction of HA grains deposited at 30 V led to an order magnitude higher polarization resistance and ten times lower corrosion current density relative to the other specimens. The porous HA layer formed at 20 V, and the presence of cracks in the 40 V-coating led to a lower corrosion resistance relative to the 30-V coating. The 20 V- and 30 V-coatings remained intact and triggered the deposition of HA during immersion in simulated body fluid for 28 days, while the 40 V-coating dissolved into the solution. The optimum EPD voltage for depositing a stable HA coating with reasonable coating thickness and the best corrosion resistance was 30 V.
Invariant polytopes of linear operators with applications to regularity of wavelets and of subdivisions

We generalize the recent invariant polytope algorithm for computing the joint spectral radius and extend it to a wider class of matrix sets. This, in particular, makes the algorithm applicable to sets of matrices that have finitely many spectrum maximizing products. A criterion of convergence of the algorithm is proved. As an application we solve two challenging computational open problems. First we find the regularity of the Butterfly subdivision scheme for various parameters $\omega$. In the "most regular" case $\omega = \frac{1}{16}$, we prove that the limit function has Holder exponent $2$ and its derivative is "almost Lipschitz" with logarithmic factor $2$. Second we compute the Holder exponent of Daubechies wavelets of high order.
Apoptosis Effects of Oxalis corniculata L. Extract on Human MCF-7 Breast Cancer Cell Line:.

Background: Recently, the non-toxic properties of natural plant products have gained more focus as anticancer agents. Therefore, this study aimed to assess the apoptosis effects of the ethanolic extract of Oxalis corniculata on the MCF-7 breast cancer cell line.Materials and Methods: In this experimental study, aerial parts of O. corniculata were collected in Lahijan city (Iran), and after confirmation, they were dried and extracted with ethanol for 24 h. Then, the total phenolic and flavonoid contents of the extract were measured. The 2,2-diphenyl-1-picrylhydrazyl radical scavenging assay was used to measure the antioxidant properties of the extract. Selected cell lines (MCF-7 and human dermal fibroblast) were cultured in 6-wells dishes (1×106 cells/well). After 72 h of treating the extract, cytotoxicity was assessed using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay. The expression of apoptotic genes (such as p53, bcl-2, bax, and CD95) was studied by real-time polymerase chain reaction (PCR). Results: The extract's total phenolic content was 31.30±02 μg of gallic acid equivalents/mg of dry extract, and the total flavonoid content was 49.61±04 μg of quercetin as equivalents/mg of extract. The antioxidant activity ofO. corniculata was measured at the dose of 619.2 μg/μl, indicating that it decreases cancer cell viability and enhances apoptosis. Within the half maximal inhibitory concentrations, real-time PCR revealed substantial increases in p53 (P<0.001), CD95 (P<0.05), and bcl-2 expression (P<0.05) in MCF-7 cells treated with O. corniculata. Conclusion: This study suggests that O. corniculata may cause apoptosis by oxidative stress in cancer cells. [GMJ.2022;11:e2484].
Effect of Gestational Pesticide Exposure on the Child’s Respiratory System: A Narrative Review

Background: In recent years, concern has arisen worldwide about the potential adverse effects that could result from early-life exposure to pesticides. Asthma, bronchitis, and persistent cough in children have been linked to gestational exposure to pesticides. The respiratory effects of gestational exposure to pesticides are controversial. The aim of this study was to determine the relationship between pesticide exposure in pregnant women and its effect on the respiratory system of their children. Methods: A narrative review was carried out by means of a search in the main databases. Results: Findings of studies confirmed the effects of pesticides on the child’s health. These substances cross the placenta and become transmitters of exposure to the individual at the most sensitive stage of her development. Conclusions: Chronic exposure to pesticides in fetuses is associated with chronic respiratory symptoms and disease.
Rational solutions of the Boussinesq equation and applications to rogue waves

We study rational solutions of the Boussinesq equation, which is a soliton equation solvable by the inverse scattering method. These rational solutions, which are algebraically decaying and depend on two arbitrary parameters, are expressed in terms of special polynomials that are derived through a bilinear equation, have a similar appearance to rogue-wave solutions of the focusing nonlinear Schrodinger (NLS) equation and have an interesting structure. Further rational solutions of the Kadomtsev-Petviashvili I (KPI) equation are derived in two ways, from rational solutions of the NLS equation and from rational solutions of the Boussinesq equation. It is shown that the two families of rational solutions of the KPI equation are fundamentally different.
Liberation theory for noncommutative homogeneous spaces

We discuss the liberation question, in the homogeneous space setting. Our first series of results concerns the axiomatization and classification of the families of compact quantum groups $G=(G_N)$ which are "uniform", in a suitable sense. We study then the quotient spaces of type $X=(G_M\times G_N)/(G_L\times G_{M-L}\times G_{N-L})$, and the liberation operation for them, with a number of algebraic and probabilistic results.
Fuzzy Laplace Transforms for Derivatives of Higher Orders

In this paper, we find the formula of fuzzy derivative of the third order and fourth order and find the fuzzy Laplace transforms for the fuzzy derivative of the above mentioned orders by using generalized H-differentiability. Keywords: Fuzzy numbers, generalized H-differentiability , Fuzzy Laplace transform.
Disclosure Of Islamic Ethical Identity, Islamic Intellectual Capital, Company Size And Financial Performance Of Sharia Banking

Penelitian ini bertujuan untuk menganalisis pengaruh pengungkapan identitas etis islam, Islamic intellectual capital, dan ukuran perusahaan terhadap kinerja keuangan perbankan syariah yang diproksikan dengan Return on Assets (ROA). Variabel pengungkapan identitas etik Islam diproksikan dengan indeks identitas etik, variabel modal intelektual Islam diproksikan dengan iB-VAIC TM , variabel ukuran perusahaan diproksikan dengan logaritma natural dari total aset. Penelitian ini menggunakan penelitian asosiatif dengan desain pendekatan kuantitatif. Populasi dan sampel dalam penelitian ini adalah Bank Umum Syariah yang terdaftar di Otoritas Jasa Keuangan periode 2016-2019. Teknik pengambilan sampel menggunakan teknik purposive sampling yang diperoleh 10 Bank Umum Syariah dan data yang digunakan sebanyak 36 data. hipotesis diuji dengan menggunakan analisis regresi berganda dengan program SPSS versi 25. Hasil penelitian ini menunjukkan bahwa pengungkapan identitas etis Islam dan modal intelektual Islam secara parsial berpengaruh positif terhadap kinerja keuangan perbankan syariah yang diproksikan dengan Return on Assets (ROA). Sedangkan variabel ukuran perusahaan berpengaruh negatif terhadap kinerja keuangan perbankan syariah yang diproksikan dengan ROA.
Constraints for the computation of optical flow

A number of constraints are proposed for which both the components of optical flow can be obtained by local differential techniques and the aperture problem can usually be solved. The constraints are suggested by the observation that it is possible to describe spatial and temporal changes of the image brightness in terms of infinitesimal deformations. An arbitrary choice of two of the four equations which correspond to the elementary deformations of a 2-D pattern implies that the spatial gradient of the image brightness is stationary and leads to a linear system of equations for optical flow which seems best suited for numerical implementation on real data in the absence of a priori information. In that case, the error term between the computed optical flow and the motion field-that is, the 2-D vector field associated with the true displacement of points on the image plane-is derived and the conditions under which it can safely be neglected are discussed. Experiments on real images are reported which show that the obtained optical flows allow the estimate of 3-D motion parameters, the detection of discontinuities in the flow field, and the segmentation of the image in different moving objects. <<ETX>>
Partial Regularity for Singular Solutions to the Monge‐Ampère Equation

We prove that solutions to the Monge‐Ampère inequality detD2u≥1 in ℝn are strictly convex away from a singular set of Hausdorff (n‐1)‐dimensional measure zero. Furthermore, we show this is optimal by constructing solutions to det D2u = 1 with singular set of Hausdorff dimension as close as we like to n‐1. As a consequence we obtain W2,1 regularity for the Monge‐Ampère equation with bounded right‐hand side and unique continuation for the Monge‐Ampère equation with sufficiently regular right‐hand side. © 2015 Wiley Periodicals, Inc.
Quality of Life of Hemodialysis Patients in Greece: Associations with Socio-Economic, Anthropometric and Nutritional Factors

Chronic kidney disease (CKD) is a serious public health problem that, in recent decades, has taken on significant dimensions with serious effects on the quality of life (QoL) of patients. The purpose of this cross-sectional study is to evaluate the QoL of a sample of hemodialysis patients in Greece and the possible correlations with socio-economic and anthropometric factors, as well as with adherence to the Mediterranean Diet (MD). During September–November 2019, one-hundred and five (n = 105) patients with end-stage CKD (63.4 ± 13.09 years of age) who were regularly monitored in five public and private hemodialysis units in the region of Attica, completed a demographic questionnaire, the MedDietScore questionnaire, and the KDQOL-SF questionnaire. Females presented worse QoL than males (p < 0.05), and older patients presented worse QoL than younger patients (p < 0.01). Patients of higher educational status presented better QoL scores than those of lower educational status (p < 0.01), while those with low financial status presented lower QoL scores than patients of middle and high financial status (p < 0.01). Obese patients had lower QoL scores than overweight patients (p < 0.05), and overweight males scored higher than normal weight males (p < 0.05). Age was negatively correlated to the total and most of the scales of QoL (p < 0.01). A majority of the patients (90.5%) showed a moderate adherence to MD, although “work status” was the only QoL scale that was correlated to MD. Age, educational status and financial status accounted for 28.1% of the variance in the KDQOL-SF total score. Hemodialysis patients need support in various levels, such as social, financial and educational, as well as nutritional counseling to adopt a balanced diet and maintain a healthy weight, in order to achieve a better quality of life.
Real models for the framed little $n$-disks operads

We study the action of the orthogonal group on the little $n$-disks operads. As an application we provide small models (over the reals) for the framed little $n$-disks operads. It follows in particular that the framed little $n$-disks operads are formal (over the reals) for $n$ even and coformal for all $n$.
Angina in 2022: Current Perspectives

Angina is the main symptom of ischemic heart disease; mirroring a mismatch between oxygen supply and demand. Epicardial coronary stenoses are only responsible for nearly half of the patients presenting with angina; whereas in several cases; symptoms may underlie coronary vasomotor disorders; such as microvascular dysfunction or epicardial spasm. Various medications have been proven to improve the prognosis and quality of life; representing the treatment of choice in stable angina and leaving revascularization only in particular coronary anatomies or poorly controlled symptoms despite optimal medical therapy. Antianginal medications aim to reduce the oxygen supply-demand mismatch and are generally effective in improving symptoms; quality of life; effort tolerance and time to ischemia onset and may improve prognosis in selected populations. Since antianginal medications have different mechanisms of action and side effects; their use should be tailored according to patient history and potential drug-drug interactions. Angina with non-obstructed coronary arteries patients should be phenotyped with invasive assessment and treated accordingly. Patients with refractory angina represent a higher-risk population in which some therapeutic options are available to reduce symptoms and improve quality of life; but robust data from large randomized controlled trials are still lacking.