Miracle-dz/UniFAR-FTUs huggingface dataset:
The Value of Myocardium and Kidney Histopathological and Immunohistochemical Findings in Accidental Hypothermia-Related Fatalities

Background and Objectives: The post-mortem diagnosis of hypothermia is challenging in forensics. The aim of our study was to detect the kidney and heart histopathological changes that occurred in a group of hypothermia-related fatalities. Materials and Methods: The cohort included 107 cases identified in the database of our department between 2007 and 2021, which have been associated with extreme cold stress. Demographic and clinicopathological data were collected from the medico-legal reports. Archived tissue samples were evaluated to identify the histopathological features, in routine haematoxylin-eosin (H&E), Periodic acid-Schiff (PAS), and Masson’s trichrome stainings, while cardiac sirtuin1 (SIRT1) and renal ubiquitin (Ub) immunostaining have been performed. Results: The majority of cases exposed to low temperatures were males (76%) from rural regions (68.2%) during the cold season. Paradoxical undressing was documented in 9.3% of cases. The common comorbidities included alcoholism (50.5%), neuropsychiatric diseases (10.3%), diabetes mellitus (3.7%), and lung tuberculosis (4.7%). The microscopic heart exam revealed areas of myocardial degeneration (100%), contraction bands (95.3%), fatty change (13.1%) and focal wavy contractile myocardial cells. Basal vacuolisation of renal tubular epithelial cells (Armanni-Ebstein lesions) (21.5%), focal tubular necrosis (7.5%), tubular renal cysts (7.5%), interstitial haemorrhages (5.6%), diabetic kidney disease (3.7%), background benign nephroangiosclerosis (42.1%), variable thickening of tubules and corpuscles basement membranes, capsular space amorphous material, and intratubular casts were identified in kidney tissue samples. Myocardial cells displayed SIRT1 weak expression, with a loss of immunopositivity correlated with areas with contraction bands, while a variable Ub expression was observed in renal corpuscles capsules, proximal, distal, and collecting renal tubules, Henle’s loops, urothelium, and intratubular casts. Conclusions: In the context of the current concept that death associated with hypothermia is still a diagnosis of exclusion, our findings suggest that the microscopic exam provides relevant data that support the diagnosis of hypothermia-related fatalities in appropriate circumstances of death. A deeper insight into the histopathologic findings in hypothermic patients may lead to new therapeutic approaches in these cases.
Post-COVID-19 Assessment of Physical, Psychological, and Socio-Economic Impact on a General Population of Patients From Odisha, India

Aim: This prospective cross-sectional study evaluated the physical, psychological, and socioeconomic impacts of post-COVID-19 conditions (PCC) in a generalized population from Odisha, India. Materials and methods: The study protocol and clinical record form (CRF) were approved by the Institutional Ethics Committee. Those above 18 years and of all genders who had recovered in the last six months, whether hospitalized or not hospitalized after the COVID-19 diagnosis, were included in our study. Results: A total of 198 persons with a median age of 41 years (18-87 years) were enrolled at the post-Covid clinic. For COVID-19 management, 91 persons (46%) were hospitalized, and the remaining 107 (54%) were non-hospitalized. Five dominant clusters of physical symptoms were present - fatigue (82.8%), cough (54%), breathing difficulty (54%), pain in the body (53%), and sleeplessness (51%). The psychological issues faced were fear (41.6%), worry (40.4%), depression (31.8%), and anger (30.3%). The median monthly income in Indian Rupees (INR) for pre-Covid versus post-Covid was 30,000 versus 25,000, effectively a loss of 16.6% in the family income. Adverse impacts on health and economic conditions were observed in 31.3% and 20.7%, respectively. Conclusion: Post-Covid clinics can be a resource-appropriate health system approach for nearly 20% of the pandemic survivors with a low gross domestic product (GDP) per capita.
Special Stanley Decompositions

Let $I$ be an intersection of three monomial prime ideals of a polynomial algebra $S$ over a field. We give a special Stanley decomposition of $I$ which provides a lower bound of the Stanley depth of $I$, greater than or equal to $\depth\ (I)$, that is, Stanley's Conjecture holds for $I$.
The Age-Accompanied and Diet-Associated Remodeling of the Phospholipid, Amino Acid, and SCFA Metabolism of Healthy Centenarians from a Chinese Longevous Region: A Window into Exceptional Longevity

As centenarians provide a paradigm of healthy aging, investigating the comprehensive metabolic profiles of healthy centenarians is of utmost importance for the pursuit of health and longevity. However, relevant reports, especially studies considering the dietary influence on metabolism, are still limited, mostly lacking the guidance of a model of healthy aging. Therefore, exploring the signatures of the integrative metabolic profiles of the healthy centenarians from a famous longevous region, Bama County, China, should be an effective way. The global metabolome in urine and the short-chain fatty acids (SCFAs) in the feces of 30 healthy centenarians and 31 elderly people aged 60–70 from the longevous region were analyzed by non-targeted metabolomics combined with metabolic target analysis. The results showed that the characteristic metabolites related to longevity were mostly summarized into phosphatidylserine, lyso-phosphatidylethanolamine, phosphatidylcholine, phosphatidylinositol, bile acids, and amino acids (p < 0.05). Six metabolic pathways were found significant relevant to longevity. Furthermore, acetic acid, propionic acid, butyric acid, valeric acid, and total SCFA were significantly increased in the centenarian group (p < 0.05) and were also positively associated with the dietary fiber intake (p < 0.01). It was age-accompanied and diet-associated remodeling of phospholipid, amino acid, and SCFA metabolism that expressed the unique metabolic signatures related to exceptional longevity. This metabolic remodeling is suggestive of cognitive benefits, better antioxidant capacity, the attenuation of local inflammation, and health-span-promoting processes, which play a critical and positive role in shaping healthy aging.
Molecular Recognition of FDA-Approved Small Molecule Protein Kinase Drugs in Protein Kinases

Protein kinases are key enzymes that catalyze the covalent phosphorylation of substrates via the transfer of the γ-phosphate of ATP, playing a crucial role in cellular proliferation, differentiation, and various cell regulatory processes. Due to their pivotal cellular role, the aberrant function of kinases has been associated with cancers and many other diseases. Consequently, competitive inhibition of the ATP binding site of protein kinases has emerged as an effective means of curing these diseases. Decades of intense development of protein kinase inhibitors (PKIs) resulted in 71 FDA-approved PKI drugs that target dozens of protein kinases for the treatment of various diseases. How do FDA-approved protein kinase inhibitor PKI drugs compete with ATP in their own binding pocket? This is the central question we attempt to address in this work. Based on modes of non-bonded interactions and their calculated interaction strengths by means of the advanced double hybrid DFT method B2PLYP, the molecular recognition of PKI drugs in the ATP-binding pockets was systematically analyzed. It was found that (1) all the FDA-approved PKI drugs studied here form one or more hydrogen bond(s) with the backbone amide N, O atoms in the hinge region of the ATP binding site, mimicking the adenine base; (2) all the FDA-approved PKI drugs feature two or more aromatic rings. The latter reach far and deep into the hydrophobic regions I and II, forming multiple CH-π interactions with aliphatic residues L(3), V(11), A(15), V(36), G(51), L(77) and π-π stacking interactions with aromatic residues F(47) and F(82), but ATP itself does not utilize these regions extensively; (3) all FDA-approved PKI drugs studied here have one thing in common, i.e., they frequently formed non-bonded interactions with a total of 12 residues L(3),V(11), A(15), K(17), E(24),V(36),T(45), F(47), G(51), L(77), D(81) and F(82) in the ATP binding. Many of those 12 commonly involved residues are highly conserved residues with important structural and catalytic functional roles. K(17) and E(24) are the two highly conserved residues crucial for the catalytic function of kinases. D(81) and F(82) belong to the DFG motif; T(45) was dubbed the gate keeper residue. F(47) is located on the hinge region and G(51) sits on the linker that connects the hinge to the αD-helix. It is this targeting of highly conserved residues in protein kinases that led to promiscuous PKI drugs that lack selectivity. Although the formation of hydrogen bond(s) with the backbone of the hinge gives PKI drugs the added binding affinity and the much-needed directionality, selectivity is sacrificed. That is why so many FDA-approved PKI drugs are known to have multiple targets. Moreover, off-target-mediated toxicity caused by a lack of selectivity was one of the major challenges facing the PKI drug discovery community. This work suggests a road map for future PKI drug design, i.e., targeting non-conserved residues in the ATP binding pocket to gain better selectivity so as to avoid off-target-mediated toxicity.
Up-and-down designs. I. Stationary treatment distributions

The primary objective of experiments motivating this work is to estimate the unknown amout ? of treatment that has a probability of response equal to a fixed value G,? < G < 1. We further assume that it is desirable to 'center' the distribution of treatments around the unknown quantile. This is accomplished by sequentially assigning treatment levels to subjects using upand-down rules, that is, rules by which the treatment used in the next trial is restricted to be one level higher, one level lower, or the same as it is for the current trial. We describe two such rules that asymptotically result in a unimodal distribution of treatment assignments with mode as close to ? as is possible given the discreteness of the treatment levels permitted. Responses are assumed to follow an extreme value function and a logistic function to illustrate how a parametric stationary treatment distribution can be determined by pairing a response function model with an up-and-down design. The designs are shown to be robust with respect to the form of the response function.
The distinct stellar metallicity populations of simulated Local Group dwarfs

A number of Local Group dwarf galaxies are known to have two spatially segregated stellar metallicity populations, a centrally concentrated metal-rich population, and a more extended metal-poor population. In this work we discuss mechanisms that lead to the formation of two spatially segregated metallicity populations. Using a set of high-resolution hydrodynamical simulations of Local Group-like environments, we select a sample of satellite and field galaxies, spanning the stellar mass range 106–109 M⊙, that exhibit bimodality in their metallicity distributions. Among those, we identify a subsample with a strong spatial segregation in the two populations. We find three distinct mechanisms for their formation. In field dwarfs and in a small fraction of satellites, a merger causes the metal-poor stars to migrate to larger radii and encourages the available gas to sink to the centre of the dwarf. Most of the gas is subsequently blown out of the halo through star formation feedback, but the remaining gas is consumed in the formation of a metal-rich population. In the exclusive case of satellites that have retained some of their gas at infall, it is the compression of this gas by ram pressure near pericentre that triggers the formation of metal-rich stars, whilst simultaneously preventing star formation at larger radii through stripping. Additionally, in a small number of field and satellite dwarfs, interactions with gaseous filaments and other galaxies can result in the formation of a metal-rich population. Regardless of the formation mechanism, a history of mergers typically enhances the spatial segregation.
Uncovering the Anticancer Potential of Polydatin: A Mechanistic Insight

Polydatin or 3-O-β-d-resveratrol-glucopyranoside (PD), a stilbenoid component of Polygonum cuspicadum (Polygonaceae), has a variety of biological roles. In traditional Chinese medicine, P. cuspicadum extracts are used for the treatment of infections, inflammation, and cardiovascular disorders. Polydatin possesses a broad range of biological activities including antioxidant, anti-inflammatory, anticancer, and hepatoprotective, neuroprotective, and immunostimulatory effects. Currently, a major proportion of the population is victimized with cervical lung cancer, ovarian cancer and breast cancer. PD has been recognized as a potent anticancer agent. PD could effectively inhibit the migration and proliferation of ovarian cancer cells, as well as the expression of the PI3K protein. The malignancy of lung cancer cells was reduced after PD treatments via targeting caspase 3, arresting cancer cells at the S phase and inhibiting NLRP3 inflammasome by downregulation of the NF-κB pathway. This ceases cell cycle, inhibits VEGF, and counteracts ROS in breast cancer. It also prevents cervical cancer by regulating epithelial-to-mesenchymal transition (EMT), apoptosis, and the C-Myc gene. The objective of this review is thus to unveil the polydatin anticancer potential for the treatment of various tumors, as well as to examine the mechanisms of action of this compound.
A New Species of the Genus Microhyla (Amphibia: Anura: Microhylidae) from the Dabie Mountains, China

Simple Summary In China, new species of Microhylidae continue to be discovered at a rapid rate, often as a result of re-examining geographically widespread species populations using new molecular and bioacoustic tools. Here, we show that members of the genus Microhyla from the Dabie mountains in East China can be distinguished from morphologically similar species (M. beilunensis, M. fanjinshanensis and M. mixtura) with the analysis of phylogeny, species delimitation, bioacoustics and morphology. Based on the above multiple lines of evidence, we describe the population of the Dabie Mountains as a new species, Microhyla dabieshanensis sp. nov. This study enriches the diversity of Microhylidae, and clarifies the species of the genus Microhyla in the Dabie Mountains. Microhyla dabieshanensis sp. nov. is distributed in the Dabie Mountains above 500 m above sea level, and in some areas has sympatric distribution with M. fissipes and M. heymonsi. Abstract Species belonging to the genus Microhyla are small-sized frogs that are widely distributed in southern, eastern, and south-eastern Asia. In China, the genus harbors many cryptic species, on two of which—M. beilunensis and M. fanjinshanensis—studies were recently published. In this study, we collected specimens from the Dabie Mountain range, which is at the junction of Anhui, Henan and Hubei Provinces, East China; these specimens belonged to a species previously identified as M. mixtura. Based on phylogenetic analyses, species delimitation analyses, morphological comparisons and advertisement calls comparisons, we found they were significantly different from other known congeners, and thus we describe them as a new species. This study enriches the diversity of Microhylidae, and clarifies the species of the genus Microhyla in the Dabie Mountains.
Polarized Radio Emission from the Magnetar XTE J1810–197

We have used the Parkes radio telescope to study the polarized emission from the anomalous X-ray pulsar XTE J1810-197 at frequencies of 1.4, 3.2, and 8.4 GHz. We find that the pulsed emission is nearly 100% linearly polarized. The position angle of linear polarization varies gently across the observed pulse profiles, varying little with observing frequency or time, even as the pulse profiles have changed dramatically over a period of 7 months. In the context of the standard pulsar "rotating vector model," there are two possible interpretations of the observed position angle swing coupled with the wide profile. In the first, the magnetic and rotation axes are substantially misaligned and the emission originates high in the magnetosphere, as seen for other young radio pulsars, and the beaming fraction is large. In the second interpretation, the magnetic and rotation axes are nearly aligned, and the line of sight remains in the emission zone over almost the entire pulse phase. We deprecate this possibility because of the observed large modulation of thermal X-ray flux. We have also measured the Faraday rotation caused by the Galactic magnetic field, RM = +77 rad m-2, implying an average magnetic field component along the line of sight of 0.5 μG.
Minecraft Education Edition in foreign language education: Pre-service teachers’ reasons for acceptance and integration

In this paper, I explored the reasons three pre-service teachers gave for why they accept and integrate Minecraft Education Edition into their growing practice. During a six-week online university course on technology in foreign language education, a group of twenty-one pre-service and in-service teachers created weekly Reflexive Digital Story (RDS) Journals to document their technology exploration along with lesson plans and projects that incorporated innovative technologies they wanted to integrate into their practice. Three of the pre-service teachers enrolled in this course became innovators and early adopters in comparison to their peers as they voluntarily integrated Minecraft Education Edition into their coursework. This allowed me to qualitatively analyze their coursework to identify the reasons they integrated the digital game into their developing practice. This work contributes to the field of digital game-based learning, technology acceptance and integration, and the study of teacher education by illuminating the factors that contribute to why pre-service teachers accept and use Virtual Worlds (VWs). I discovered the reasons these pre-service teachers gave for acceptance and use of VW technology embodied the recognition of a need for motivation and engagement in the classroom, beliefs about the social nature of culture and language, and perceptions of VWs as an opportunity to make the impossible possible.
Ionosphere-thermosphere global time response to geomagnetic storms

In this study, we investigate thermospheric neutral mass density heating associated with 168 CME-driven geomagnetic storms in the period of May 2001 to September 2011. We use neutral density measured by two low-Earth orbit satellites: CHAMP and GRACE. For each storm, we superpose geomagnetic and density data for the time when the IMF B$_\mathrm{z}$ component turns sharply southward chosen as the zero epoch time. This indicates the storm main phase onset. We find that the average SYM-H index reaches the minimum of $-$42 nT near 12 hours after storm main phase onset. The Joule heating is enhanced by approximately 200\% in comparison to quiet values. In respect to thermosphere density, on average, high latitude regions (auroral zones and polar caps) of both hemispheres are highly heated in the first 1.5 hour of the storm. The equatorial response is presumably associated with direct equator-ward propagation of TADs (traveling atmospheric disturbances). A slight north-south asymmetry in thermosphere heating is found and is most likely due to a positive B$_\mathrm{y}$ component in the first hours of the storm main phase.
Declining Rotation Curves at z = 2 in ΛCDM Galaxy Formation Simulations

Selecting disk galaxies from the cosmological, hydrodynamical simulation Magneticum Pathfinder, we show that almost half of our poster child disk galaxies at z = 2 show significantly declining rotation curves and low dark matter fractions, very similar to recently reported observations. These galaxies do not show any anomalous behavior, they reside in standard dark matter halos, and they typically grow significantly in mass until z = 0, where they span all morphological classes, including disk galaxies matching present-day rotation curves and observed dark matter fractions. Our findings demonstrate that declining rotation curves and low dark matter fractions in rotation-dominated galaxies at z = 2 appear naturally within the ΛCDM paradigm and reflect the complex baryonic physics, which plays a role at the peak epoch of star formation. In addition, we find some dispersion-dominated galaxies at z = 2 that host a significant gas disk and exhibit similar shaped rotation curves as the disk galaxy population, rendering it difficult to differentiate between these two populations with currently available observation techniques.
Point Defects Stability, Hydrogen Diffusion, Electronic Structure, and Mechanical Properties of Defected Equiatomic γ(U,Zr) from First-Principles

At present, many experimental fast reactors have adopted alloy nuclear fuels, for example, U-Zr alloy fuels. During the neutron irradiation process, vacancies and hydrogen (H) impurity atoms can both exist in U-Zr alloy fuels. Here, first-principles density functional theory (DFT) is employed to study the behaviors of vacancies and H atoms in disordered-γ(U,Zr) as well as their impacts on the electronic structure and mechanical properties. The formation energy of vacancies and hydrogen solution energy are calculated. The effect of vacancies on the migration barrier of hydrogen atoms is revealed. The effect of vacancies and hydrogen atom on densities of states and elastic constants are also presented. The results illustrate that U vacancy is easier to be formed than Zr vacancy. The H interstitial prefers the tetrahedral site. Besides, U vacancy shows H-trap ability and can raise the H migration barrier. Almost all the defects lead to decreases in electrical conductivity and bulk modulus. It is also found that the main effect of defects is on the U-5f orbitals. This work provides a theoretical understanding of the effect of defects on the electronic and mechanical properties of U-Zr alloys, which is an essential step toward tailoring their performance.
Likelihood and Pseudo-likelihood Estimation Based on Response-Biased Observation

Response-biased observation refers to situations where the probability a unit is observed depends on the value of a response associated with that unit. We discuss the construction of estimating equations for parametric regression models through likelihood and pseudo likelihoods, for situations in which responses are stratified and sampling is stratum-specific. Properties of the resulting estimators are reviewed and an illustration involving field reliability data is presented.
Sustained propagation and control of topological excitations in polariton superfluid

We present a simple method to compensate for losses in a polariton superfluid. Based on a weak support field, it allows for the extended propagation of a resonantly driven polariton superfluid with minimal energetic cost. Moreover, this setup is based on optical bistability and leads to the significant release of the phase constraint imposed by resonant driving. This release, together with macroscopic polariton propagation, offers a unique opportunity to study the hydrodynamics of the topological excitations of polariton superfluids such as quantized vortices and dark solitons. We numerically study how the coherent field supporting the superfluid flow interacts with the vortices and how it can be used to control them. Interestingly, we show that standard hydrodynamics does not apply for this driven-dissipative fluid and new types of behaviour are identified.