Miracle-dz/UniFAR-FTUs huggingface dataset:
Evaluation of salivary transferrin in patients with oral squamous cell carcinoma

Abstract Objectives About 94% of oral cancers are squamous cell carcinomas (OSCCs). Its occurrence is age‐related due to some factors. Salivary biomarkers have good susceptibility to OSCC's early diagnosis. Moreover, since the clinical diagnosis of advanced stages of OSCC is feasible, its prognosis is very poor. Material and Methods According to inclusion and exclusion criteria, 40 OSCC patients and 40 healthy people were selected, and 5 mL of saliva were prepared from each person. The quantity of saline transferrin was computed. After that, the data were analyzed. Results Our study results demonstrated that the mean and standard deviation of the salivary transferrin in the control group were 1.234 mL and 0.374, respectively, and in the case group, it was equal to 2.512 mL for the mean and 0.463 for the standard deviation. There was a statistically substantial difference between the mean of the salivary transferrin variable in the two study groups. Conclusion In conclusion, the mean concentration of salivary transferrin in the case group was higher than in the control group.
Tissue-derived exosome proteomics identifies promising diagnostic biomarkers for esophageal cancer

Esophageal cancer (EC) is a fatal digestive disease with a poor prognosis and frequent lymphatic metastases. Nevertheless, reliable biomarkers for EC diagnosis are currently unavailable. Accordingly, we have performed a comparative proteomics analysis on cancer and paracancer tissue-derived exosomes from eight pairs of EC patients using label-free quantification proteomics profiling and have analyzed the differentially expressed proteins through bioinformatics. Furthermore, nano-flow cytometry (NanoFCM) was used to validate the candidate proteins from plasma-derived exosomes in 122 EC patients. Of the 803 differentially expressed proteins discovered in cancer and paracancer tissue-derived exosomes, 686 were up-regulated and 117 were down-regulated. Intercellular adhesion molecule-1 (CD54) was identified as an up-regulated candidate for further investigation, and its high expression in cancer tissues of EC patients was validated using immunohistochemistry, real-time quantitative PCR (RT-qPCR), and western blot analyses. In addition, plasma-derived exosome NanoFCM data from 122 EC patients concurred with our proteomic analysis. The receiver operating characteristic (ROC) analysis demonstrated that the AUC, sensitivity, and specificity values for CD54 were 0.702, 66.13%, and 71.31%, respectively, for EC diagnosis. Small interference (si)RNA was employed to silence the CD54 gene in EC cells. A series of assays, including cell counting kit-8, adhesion, wound healing, and Matrigel invasion, were performed to investigate EC viability, adhesive, migratory, and invasive abilities, respectively. The results showed that CD54 promoted EC proliferation, migration, and invasion. Collectively, tissue-derived exosomal proteomics strongly demonstrates that CD54 is a promising biomarker for EC diagnosis and a key molecule for EC development.
A statistical method based on remote sensing for the estimation of air temperature in China

Environmental applications require accurate air temperature (Tair) datasets with different temporal and spatial resolutions. Existing methods generally improve the estimation accuracy of Tair using environmental variables as auxiliary data to overcome problems related to sparse metrological stations. However, these data are always fixed and do not comprehensively explain the variations in Tair values at all temporal and spatial scales. Moreover, these methods seldom consider the spatial heterogeneity of relationships between Tair and auxiliary data. This heterogeneity is often caused by several factors, such as land type, topography, and climate. This study proposes an estimation method to produce maximum, minimum, and mean Tair (Tmax, Tmin, and Tmean) datasets at different temporal and spatial resolutions using satellite‐derived digital elevation model data and both nighttime and daytime land surface temperature data as auxiliary data. The method is based on the assumption that the relationships between Tair and the chosen auxiliary data vary spatially. These relationships were further explored using geographically weighted regression with adaptive bi‐square kernel function. The derived relationships were used to construct a Tair estimation model. Monthly Tair data with 5‐km resolution and 8‐day Tair data with 1‐km resolution were produced for 2010. The results show that the proposed method can accurately represent the variations in Tair; the R2 values were in the range of 0.95–0.99 for the monthly Tair data and 0.93–0.99 for the 8‐day Tair data. The root mean square errors (RMSEs) for the monthly and 8‐day Tmax, Tmin, and Tmean data of the year 2010 were 1.29 and 1.45 °C, 1.24 and 1.29 °C, and 0.8 and 1.2 °C, respectively. These results were compared with those from other estimation methods, specifically the estimation of Tair based on multiple linear regression (EATMLR) and regression kriging (EATRK). The proposed method was found to produce RMSEs that were 25–26% smaller than EATMLR and 34–42% smaller than EATRK.
Exaggerated mandibles are correlated with enhanced foraging efficacy in male Auckland tree wētā

Sexual selection has driven the evolution of weaponry for males to fight rivals to gain access to females. Although weapons are predicted to increase males' reproductive success, they are also expected to incur costs and may impair functional activities, including foraging. Using feeding assays, we tested whether the enlarged mandibles of Auckland tree wētā (Hemideina thoracica) impact feeding activity (the total volume of biomass consumed, bite rate, and number of foraging visits) and foraging behaviour (time spent moving, feeding, or stationary). We predicted that increased head capsule size in male wētā would hinder their foraging efficacy. However, we found that wētā with longer heads fed at a faster rate and spent less time foraging than wētā with smaller heads, regardless of sex. Contrary to expectations that weapons impede functional activities, our results demonstrate that exaggerated traits can improve feeding performance and may offer benefits other than increased mating success.
Status Logam Berat Merkuri (Hg) Dalam Tanah Pada Kawasan Pengolahan Tambang Emas Di Kelurahan Poboya, Kota Palu

Along with the discovery of several gold prospects area in ​​Central Sulawesi, gold mining had increased both by companies, cooperatives and illegal mining. The activity of this mining produce waste that consist of hazardous toxic substances in which there was a heavy metal such as mercury (Hg). This metal is one of the trace elements that has liquid at room temperature, high specific gravity and power electric conductivity, and a toxic chemical element became a global concern because has significant hazardous effect on human health, wildlife and ecosystems. This study was aims to know the content of mercury in soil around the Poboya’s gold mining. The method used in this study was a survey which describes the actually condition of this area and assess the causes of certain symptoms. In this study measurements, field observations, and laboratory analysis had been done. There step that be noticed in this survey were pre-survey, main survey (sampling) and laboratory analysis. Compose soil sample for laboratory analysis had been collected from several sample point that had been plotting by tactics. The results of this study showed that the content of mercury in all representative soil sample and tailings had highest than threshold. Normally, concentrations of mercury in the soil range from 0.03 ppm (normal) to 0.3 to 0.5 ppm (critics); while concentrations of mercury in soil agricultural areas ranged from 0.057 ppm to 8.19 ppm and in tailings ranged from 84.15 ppm - 575, 16 ppm.
Follistatin-like 1 protects endothelial function in the spontaneously hypertensive rat by inhibition of endoplasmic reticulum stress through AMPK-dependent mechanism

ABSTRACT Objective Endothelial dysfunction is a critical initiating factor in the development of hypertension and related complications. Follistatin-like 1 (FSTL1) can promote endothelial cell function and stimulates revascularization in response to ischemic insult. However, it is unclear whether FSTL1 has an effect on ameliorating endothelial dysfunction in spontaneously hypertensive rats (SHRs). Methods Wistar Kyoto (WKY) and SHRs were treated with a tail vein injection of vehicle (1 mL/day) or recombinant FSTL1 (100 μg/kg body weight/day) for 4 weeks. Blood pressure was measured by tail-cuff plethysmograph, and vascular reactivity in mesenteric arteries was measured using wire myography. Results We found that treatment with FSTL1 reversed impaired endothelium-dependent relaxation (EDR) in mesenteric arteries and lowered blood pressure of SHRs. Decreased AMP-activated protein kinase (AMPK) phosphorylation, elevated endoplasmic reticulum (ER) stress markers, increased reactive oxygen species (ROS), and reduction of nitric oxide (NO) production in mesenteric arteries of SHRs were also reversed by FSTL1 treatment. Ex vivo treatment with FSTL1 improved the impaired EDR in mesenteric arteries from SHRs and reversed tunicamycin (ER stress inducer)-induced ER stress and the impairment of EDR in mesenteric arteries from WKY rats. The effects of FSTL1 were abolished by cotreatment of compound C (AMPK inhibitor). Conclusions These results suggest that FSTL1 prevents endothelial dysfunction in mesenteric arteries of SHRs through inhibiting ER stress and ROS and increasing NO production via activation of AMPK signaling.
Sex steroid levels in corresponding cerebrospinal fluid and serum samples quantified by mass spectrometry in men

Objective Sex steroids exert important biological functions within the CNS, but the underlying mechanisms are poorly understood. The contribution of circulating sex steroids to the levels in CNS tissue and cerebrospinal fluid (CSF) has been sparsely investigated in human and with inconclusive results. This could partly be due to lack of sensitive validated assays. To address this, we validated a gas chromatography–tandem mass spectrometry (GC-MS/MS) assay for quantification of sex steroid hormones/precursors in CSF. Methods GC-MS/MS quantification of dihydrotestosterone (DHT, CSF lower limit of quantification, 1.5 pg/mL), testosterone (4.9), estrone (E1, 0.88), estradiol (E2, 0.25), dehydroepiandrosterone (DHEA, 38.4), androstenedione (4D, 22.3), and progesterone (P, 4.2) in CSF, and corresponding serum samples from 47 men. Results Analyses of CSF revealed that DHEA was the major sex steroid (73.5 ± 31.7 pg/mL) followed by 4D (61.4 ± 29.6 pg/mL) and testosterone (49.5 ± 18.9 pg/mL). The CSF levels of DHT, E2, and E1 were substantially lower, and P was in general not detectable in CSF. For all sex steroids except E2, strong associations between corresponding CSF and serum levels were observed. We propose that testosteronein CSF is derived from circulating testosterone, DHT in CSF is from local conversion from testosterone, while E2 in CSF is from local conversion from 4D in CNS. Conclusions We describe the first thoroughly validated highly sensitive mass spectrometric assay for a broad sex steroid hormone panel suitable for human CSF. This assay constitutes a new tool for investigation of the role of sex steroid hormones in the human CNS. Significance statement In this study, a fully validated highly sensitive mass spectrometric assay for sex steroids was applied to human CSF. The results were used to describe the relative contribution of peripheral circulating sex steroids together with locally transformation of sex steroids to the levels in CSF. The results are of importance to understand the biological processes of the human brain.
Seasonal and Spatial Variations in Fishing Intensity and Gearwise Landings of the Vembanad Lake

The variations noticed in the fishing intensity on an annual basis in the different regions of the Vembanad lake arc discussed. Stake nets and dip nets acconnted for 72.48% of the total landings; the former contributing to 53.14%. The contributions from gill nets, seines, cast nets, line fishing and other indigenous fishing methods are respectively 10.15, 9.68, 3.49, 2.54 and 1.66%. Stake and dip nets are almost confined to the northern sector (Cochin backwaters), contributing 57 and 20.7% respectively of the production. Seines and gill nets acconnted for 8.5 and 8.3% respectively in this sector. In the southern sector (Thannecrmukkom to Allcppey), the stationary gears are rarely noticed, the major part of the landings being obtained from gill nets (34.34%), seines (24.67%) and cast nets (19.04%).
Self-collected samples as an additional option for STI testing in low-resource settings: a qualitative study of acceptability among adults in Rakai, Uganda

Introduction Self-collected samples (SCS) for sexually transmitted infection (STI) testing have been shown to be feasible and acceptable in high-resource settings. However, few studies have assessed the acceptability of SCS for STI testing in a general population in low-resource settings. This study explored the acceptability of SCS among adults in south-central Uganda. Methods Nested within the Rakai Community Cohort Study, we conducted semistructured interviews with 36 adults who SCS for STI testing. We analysed the data using an adapted version of the Framework Method. Results Overall, SCS was acceptable to both male and female participants, regardless of whether they reported recent STI symptoms. Perceived advantages of SCS over provider-collection included increased privacy and confidentiality, gentleness and efficiency. Disadvantages included the lack of provider involvement, fear of self-harm and the perception that SCS was unhygienic. Most participants preferred provider-collected samples to SCS. Nevertheless, almost all said they would recommend SCS and would do it again in the future. Conclusion SCS are acceptable among adults in this low-resource setting and could be offered as an additional option to expand STI diagnostic services.
Trigger tool-based description of adverse events in helicopter emergency medical services in Qatar

Introduction Adverse events (AEs) in helicopter emergency medical services (HEMS) remain poorly reported, despite the potential for harm to occur. The trigger tool (TT) represents a novel approach to AE detection in healthcare. The aim of this study was to retrospectively describe the frequency of AEs and their proximal causes (PCs) in Qatar HEMS. Methods Using the Pittsburgh Adverse Event Tool to identify AEs in HEMS, we retrospectively analysed 804 records within an existing AE TT database (21-month period). We calculated outcome measures for triggers, AEs and harm per 100 patient encounters, plotted measures on statistical process control charts, and conducted a multivariate analysis to report harm associations. Results We identified 883 triggers in 536 patients, with a rate of 1.1 triggers per patient encounter, where 81.2% had documentation errors (n=436). An AE and harm rate of 27.7% and 3.5%, respectively, was realised. The leading PC was actions by HEMS Crew (81.6%; n=182). The majority of harm (57.1%) stemmed from the intervention and medication triggers (n=16), where deviation from standard of care was common (37.9%; n=11). Age and diagnosis-adjusted odds were significant in the patient condition (6.50; 95% CI 1.71 to 24.67; p=0.01) and interventional (11.85; 95% CI 1.36 to 102.92; p=0.03) trigger groupings, while age and diagnosis had no effect on harm. Conclusion The TT methodology is a robust, reliable and valid means of AE detection in the HEMS domain. While an AE rate of 27.7% is high, more research is required to understand prehospital clinical decision-making and reasons for guideline deviance. Furthermore, focused quality improvement initiatives to reduce AEs and documentation errors should also be addressed in future research.
Organ-On-A-Chip: An Emerging Research Platform

ABSTRACT In drug development, conventional preclinical and clinical testing stages rely on cell cultures and animal experiments, but these methods may fall short of fully representing human biology. To overcome this limitation, the emergence of organ-on-a-chip (OOC) technology has sparked interest as a transformative approach in drug testing research. By closely replicating human organ responses to external signals, OOC devices hold immense potential in revolutionizing drug efficacy and safety predictions. This review focuses on the advancements, applications, and prospects of OOC devices in drug testing. Based on the latest advances in the field of OOC systems and their clinical applications, this review reflects the effectiveness of OOC devices in replacing human volunteers in certain clinical studies. This review underscores the critical role of OOC technology in transforming drug testing methodologies.
High School Teachers’ Experiences of Consumer Technologies for Stress Management During the COVID-19 Pandemic: Qualitative Study

Background Stress in education is an adverse reaction that teachers have to excessive pressures or other types of demands placed on them. Consumer digital technologies are already being used by teachers for stress management, albeit not in a systematic way. Understanding teachers’ experiences and the long-term use of technologies to support stress self-management in the educational context is essential for meaningful insight into the value, opportunity, and benefits of use. Objective The aim of this study was first to understand teachers’ experiences of consumer technologies for stress management. They were chosen by teachers from a taxonomy tailored to their stress management. The second aim was to explore whether their experiences of use evolved over time as teachers transitioned from working at home during lockdown to working full time on school premises. Methods A longitudinal study intended for 6 weeks in the summer term (2020) was extended because of COVID-19 into the autumn term, lasting up to 27 weeks. Teachers chose to use a Withings smartwatch or the Wysa, Daylio, or Teacher Tapp apps. In total, 2 semistructured interviews and web-based surveys were conducted with 8 teachers in South London in the summer term, and 6 (75%) of them took part in a third interview in the autumn term. The interviews were analyzed by creating case studies and conducting cross-case analysis. Results The teachers described that the data captured or shared by the technology powerfully illustrated the physical and psychosocial toll of their work. This insight gave teachers permission to destress and self-care. The social-emotional confidence generated also led to empathy toward colleagues, and a virtuous cycle of knowledge, self-compassion, permission, and stress management action was demonstrated. Although the COVID-19 pandemic added a new source of stress, it also meant that teachers’ stress management experiences could be contrasted between working from home and then back in school. More intentional self-care was demonstrated when back in school, sometimes without the need to refer to the data or technology. Conclusions The findings of this study demonstrate that taking a situated approach to understand the real-world, existential significance and value of data generates contextually informed insights. Where a strategic personal choice of consumer technology is enabled for high school heads of year, the data generated are perceived as holistic, with personal and professional salience, and are motivational in the educational context. Technology adoption was aided by the pandemic conditions of home working, and this flexibility would otherwise need workplace facilitation. These findings add to the value proposition of technologies for individual stress management and workforce health outcomes pertinent to educators, policy makers, and designers.
Occurrence of some mycotoxins residues in meat and meat products with studying the effect of different food processing methods on mycotoxin stability in meat samples.

رجرب فٌبلاو نوشنلالاو ةدمجملا موحللاو ةجزاطلا موحللا نم ةنٌع نوثلاثو ناتنثا عٌمجت مت ( 8 عون لك نم تانٌع ) نم ةرتفلا ىف ةٌردنكسلإا ةنٌدمب ةفلتخم نكامأ نم اٌئاوشع اعٌمجت ربمسٌد ىلا ربوتكأ رهش 2009 نٌسكوتلافلألا ةٌرطفلا مومسلا اٌاقب دجاوت ىدم ساٌقل ًفارجوتاموركلا لصفلا زاهج مادختساب نونٌلارٌزلاو HPLC) ,) نأ جئاتنلا ترهظأ ثٌح ةدمجملا موحللا تانٌع ىف تدجو نٌسكوتلافلأا اٌاقب نم ةٌمك ىلعأ 0.87 مارجوركٌم / نوشنلالا تانٌع ىف تدجو ةٌمك لقأ امنٌب مارجولٌك 0.41 مارجوركٌم / مارجولٌك , امنٌب نوشنلالا تانٌع ىف تدجو نونٌلارٌزلا اٌاقب نم ةٌمك ىلعأ تناك 2.96 مارجوركٌم / رجرب فٌبلا تانٌع ىف تدجو ةٌمك لقأو مارجولٌك 2.15 مارجوركٌم / مارجولٌك . ةبسنلاب مت دقف نونٌلارٌزلا يرطفلا مسلا تابث ًلع موحلل ةفلتخملا ةٌئاذغلا تلاماعملا رٌثأت ةساردل نقح 15 اهنزو محللا نم ةعطق ًف نونٌلارٌزلا نم مارجوركٌم 200 دنع دٌمجتلا لبق مارج 20 ° دعب مث موٌ دعب ًفارجوتاموركلا لصفلا زاهجب نونٌلارٌزلا ةٌمك ساٌقو صلاختسا مث م 30.21. 14.7. 4 رٌخأو ًا 60 ًلاوتلا ًلع اموٌ , ًلع ةٌرارحلا ةجلاعملا رٌثأت رابتخا اضٌأو ةجرد دنع اهٌلغو موحللا ًهطب نونٌلارٌزلا زٌكرت 100 ° ةدمل م 45 ةقٌقد , رٌثأت كلذكو ةدمل رشابملا بهللا ًلع ءاوشلا 11 ةقٌقد 0 ةجردب لقت ةصلختسملا مومسلا ةٌمك نأ دجو دقو دج ةدودحم اًا ةفلتخملا ةٌرارحلا تلاماعملاب رثأتٌ لا تباث بكرم نونٌلارٌزلا نأ ىنعٌ امم موحلل 0 كلذكو ةماعلا ةحصلا ًلع اهرٌثأتو ةٌرطفلا مومسلل ةٌحصلا ةٌمهلأا ةشقانم تمت دقو اهتاجتنمو موحللا ةدوج نٌسحتل رابتعلاا ًف اهعضو بجٌ ًتلا تاحارتقلاا 0
Predicting Moffitt's Developmental Taxonomy of Antisocial Behavior Using Life History Theory: A Partial Test of the Evolutionary Taxonomy

Evolutionary criminology is an approach to the understanding of crime and criminality that is based in part on key aspects of evolutionary psychology. The approach allows for a renewed examination of traditional criminological assumptions and can serve to further enhance theoretical viewpoints on antisocial behavior. The recently developed evolutionary taxonomy theory is an example of such an approach. Relying on the tenets of life history theory, the evolutionary taxonomy was proposed as a theoretical scaffolding for Moffitt's developmental taxonomy of offending. While recent tests of the evolutionary taxonomy have been informative, lacking from the existing literature is an assessment of the extent to which measures of life history theory can predict classification into offending groups based on Moffitt's developmental taxonomy. The current study provided a partial test of classification predictions using the National Longitudinal Study of Adolescence to Adult Health study (n = 12,012). Results of multivariable regression analyses indicated that measures associated with somatic effort and aspects of the developmental environment were predictive of group classification, but measures associated with reproductive effort were not. Implications for evolutionary criminology and traditional criminology are discussed.