Miracle-dz/UniFAR-FTUs huggingface dataset:
Fndc5/irisin is regulated by myogenesis stage, irisin, muscle type and training.

OBJECTIVES Irisin, a novel myokine that responds to exercise, was initially identified as a regulator of fat tissue metabolism. We aimed to investigate fibronectin type III domain-containing protein 5 (Fndc5)/irisin, auto/para-crine role in different muscle fibers, different activities, and muscle cell differentiation. METHODS Using in-vitro, ex-vivo, and in-vivo muscle models, Fndc5 was studied at the physiological and molecular levels. RESULTS Following training, C57BL/6 mice (n=10) were subject to fast and slow-twitch muscles dissection and molecular analysis. Isolated mice (C57BL/6, n=14) slow and fast-twitch muscles were subject to electrical aerobic and anaerobic pulses stimulation (EPS). L6 muscle cells differentiation was characterized by Fndc5 differentiation-depended expression pattern parallel with significant hypertrophy, Myogenin elevation, and overlapping Peroxisome proliferator-activated receptor-gamma coactivator-1 alpha (Pgc-1α) expression pattern. Exogenous irisin significantly altered Fndc5 expression; augmented at early differentiation (3-4-fold, P<0.05) and decreased (2-fold, P<0.05) at late differentiation. Training induced a significant elevation in Fndc5/irisin and Pgc-1α expression levels in all muscle types compared to the sedentary state, where soleus muscle (slow) Fndc5 expression levels were significantly higher compared to levels in all other fast muscles (3-140-fold, P<0.001). Similarly, following EPS, Fndc5 expression levels were significantly augmented in the soleus slow muscle following both aerobic and anaerobic activity (3-3.5-fold, P<0.05) compared to extensor digitorum longus (fast) muscle. CONCLUSIONS Muscle cell's Fndc5 expression has a differentiation-depended pattern paralleling Pgc-1α expression and hypertrophy. Irisin autocrinally and significantly regulate Fndc5 and Pgc-1α in a differentiation-depended manner. Muscle Fndc5 expression levels are dependent on fiber type and activity type.
The effects of high-velocity supernova kicks on the orbital properties and sky distributions of neutron-star binaries

We systematically investigate the effects of high supernova kick velocities on the orbital parameters of post-supernova neutron-star binaries. Using Monte- Carlo simulations, we determine the post-supernova distributions of orbital parameters for progeneitors of HMXBs and LMXBs. With the recent distribution of pulsar birth velocities by Lyne & Lorimer (1994), only about 27% of massive systems remain bound after the supernova, of which about 26% immediately experience dynamical mass transfer and possibly merge to become Thorne-Zytkow objects. The correlations between various orbital parameters can be compared with observational samples to yield information about supernova kick velocities and pre-supernova orbital-period distributions. After the supernova, the spins of most stars in massive systems have large inclinations with respect to their orbital axes, and a significant fraction of systems (about 20%) contain stars with retrograde spins. In the case of low-mass companions, we find that about 19% of systems remain bound after the supernova, of which about 57% experience immediate dynamical mass transfer. There is a tight correlation between the eccentricity and the post-supernova orbital period in LMXB progeneitors. All LMXBs with post-supernova periods longer than a few days initially have large eccentricities (e.g. Cir X-1 is discussed in this context). We use the results of these calculations to simulate the sky distributions of HMXBs and LMXBs. The simulated distributions agree with observed samples. Most importantly, the distribution of Galactic LMXBs is consistent with an ordinary Galactic disk population which has been widened because of large supernova kicks and does not require a special population of progenitors.
Does Double Reading of Screening Breast MRI Scans Impact Recall Rates and Cancer Detection?

Objective: To investigate the effect of double reads by a second radiologist on cancer detection rate (CDR), positive predictive value of recommendation for tissue diagnosis (PPV2), and the positive predictive value of biopsy performed (PPV3) for biopsy recommendations in high-risk screening breast MRIs. Methods: The policy of second reads on biopsies recommended for MRIs was prospectively implemented in October 2019. This IRB approved retrospective analysis compared consecutive high-risk screening breast MRI scans performed in a single academic institution between 06/01/2018 to 06/01/2019 (pre-intervention) with screening breast MRI scans performed between 10/31/2019 to 10/31/2020 (post-intervention). Pathology results after biopsy were recorded. Testing of association was performed using the Chi-square test. Results/Discussion: A total of 1124 screening breast MRIs in the pre-intervention and 1672 screening breast MRIs were performed in the post-intervention periods. Biopsies were recommended in 8.6% (97/1124) of pre-intervention and 5.5% (92/1672) of post-intervention MRIs (P = .0012). There was a non-significant increase in PPV2 from pre-intervention 10.3% (10/97) to post-intervention 18.4% (17/92) (P = .109) and in PPV3 from 14% (10/71) to 22.9% (17/74), respectively (P = .17). Similar cancer detection rates, 8.9/1000 (10/1124) and 10.2/1000 (17/1672) (P = .736) were diagnosed in pre-intervention and post-intervention periods, respectively. Conclusion: Double reading of screening breast MRI scans significantly reduced the number of unnecessary biopsies without significant impact in the PPVs or cancer detection rate. Visual Abstract
The merging history of the Milky Way

The age distribution, and chemical elemental abundances, of stars in the halo of the Milky Way provide constraints on theories of galaxy formation. As one specific example, the accretion of satellite galaxies similar to the present retinue of dwarf spheroidals (dSphs) would provide an observable metal-poor, intermediate-age population. This paper presents a quantitative assessment of any contribution made by such stars to the stellar halo. The bulk of the stellar populations in the halo show a well-defined turn-off, at B-V ~ 0.4, implying that the vast majority of the stars are old. The fraction of stars which lie blueward of this well-defined turn-off, with metallicities similar to that of the present dSphs, is used in this paper to place limits on the importance of the recent accretion of such systems. Very few ( ~ -1.5 dex). Direct comparison of this statistic with the colour distribution of the turnoff stars in the Carina dwarf allows us to derive an upper limit on the number of mergers of such satellite galaxies into the halo of the Milky Way. This upper limit is ~ 40 Carina-like galaxies. The higher metallicity data constrain satellite galaxies like the Fornax dwarf; only <~ 5 of these could have been accreted within the last < ~ 10 Gyr. We note that the low star-formation rates inferred for dSphs predict distinctive elemental abundance signatures; future data for field halo stars, including candidate younger stars, will provide a further robust test of accretion models.
TP53‐altered acute myeloid leukemia and myelodysplastic syndrome with excess blasts should be approached as a single entity

TP53‐altered myelodysplastic syndrome with excess blasts and TP53‐altered acute myeloid leukemia should be considered under one unifying classification term for their study in clinical trials. Ultimately, such a unification would simplify the screening processes for clinical trials and allow a focus on treating the patient for a genetically defined disorder rather than one based on an arbitrary blast threshold.
Electro‐Synthesis of Organic Compounds with Heterogeneous Catalysis

Electro‐organic synthesis has attracted a lot of attention in pharmaceutical science, medicinal chemistry, and future industrial applications in energy storage and conversion. To date, there has not been a detailed review on electro‐organic synthesis with the strategy of heterogeneous catalysis. In this review, the most recent advances in synthesizing value‐added chemicals by heterogeneous catalysis are summarized. An overview of electrocatalytic oxidation and reduction processes as well as paired electrocatalysis is provided, and the anodic oxidation of alcohols (monohydric and polyhydric), aldehydes, and amines are discussed. This review also provides in‐depth insight into the cathodic reduction of carboxylates, carbon dioxide, CC, C≡C, and reductive coupling reactions. Moreover, the electrocatalytic paired electro‐synthesis methods, including parallel paired, sequential divergent paired, and convergent paired electrolysis, are summarized. Additionally, the strategies developed to achieve high electrosynthesis efficiency and the associated challenges are also addressed. It is believed that electro‐organic synthesis is a promising direction of organic electrochemistry, offering numerous opportunities to develop new organic reaction methods.
Ecology of dark matter haloes –II. Effects of interactions on the alignment of halo pairs

We use the Horizon Run 4 cosmological N -body simulation to study the effects of distant and close interactions on the alignments of the shapes, spins, and orbits of targets haloes with their neighbours, and their dependence on the local density environment and neighbour separation. Interacting targets have a significantly lower spin and higher sphericity and oblateness than all targets. Interacting pairs initially have anti-parallel spins, but the spins develop parallel alignment as time goes on. Neighbours tend to evolve in the plane of rotation of the target, and in the direction of the major axis of prolate haloes. Moreover, interactions are preferentially radial, while pairs with non-radial orbits are preferentially prograde. The alignment signals are stronger at high-mass and for close separations, and independent on the large-scale density. Positive alignment signals are found at redshifts up to 4, and increase with decreasing redshifts. Moreover, the orbits tend to become prograde at low redshift, while no alignment is found at high redshift (z = 4).
Identification of psychological stressors in cancer patients based on a computer decision support nursing system.

OBJECTIVE We aim to improve the decision-making process of nursing evaluation, and the purpose of this paper was to introduce nursing outcome classifications based on standardized nursing language, as well as build a comprehensive nursing evaluation decision-making system model based on an artificial neural network and fuzzy comprehensive evaluations. METHODS Based on the principle and method of the decision support system (DSS), this paper proposed a framework of DSS and developed an intelligent nursing decision support system which integrates expert systems, data, models and knowledge. RESULTS Taking cancer patients as examples, based on the analysis and comparison of cancer stressors and their frequency of occurrence, this paper found that the 5 major factors for cancer patients' stress events were lack of privacy, attitude of the medical workers, unfamiliar medical workers and uncomfortable temperature in wards. In addition, through the single factor analysis of the stressors, it was found that "the impact of hospitalization on individuals and their families", "the professional level and service attitude of medical workers", and "partial loss of free social contact in the hospital" were all positively correlated with stress level. The degree of cancer patients' participation in treatment decision-making was lower than the expectation of the patients. There was a statistically significant difference between the actual participation and the anticipated participation of cancer patients in nursing decision-making (P < 0.0001). In addition, the system helped patients adapt to the hospital environment as quickly as possible, so that they could feel comfortable in the hospital environment, as well as a relaxed and pleasant with the humanistic environment. CONCLUSION Cancer patients have a variety of stressors, and the pressure is high. Our computer decision support nursing system assisted nurses to help patients to take positive coping measures to relieve pressure as soon as possible, so as to improve their quality of life.
Effect of primary tumor resection on survival in patients with asymptomatic unresectable metastatic colorectal cancer: a systematic review and meta-analysis

ABSTRACT Objective It remains controversial whether primary tumor resection (PTR) improves survival in patients with asymptomatic, unresectable metastatic colorectal cancer (mCRC). Therefore, we conducted a meta-analysis to assess the latest evidence on clinical outcomes. Materials and Methods We systematically searched PubMed, Web of Science, Cochrane Library, and Embase databases for eligible studies published between database inception and May 2022. RevMan 5.4 and Stata 16.0 were used for the meta-analysis. Results A total of nine studies were included, including four randomized controlled trials (RCTs) and five retrospective cohort studies. Meta-analysis showed that overall survival (OS) [HR = 0.89, 95%CI (0.74, 1.06), P = 0.19] and progression-free survival (PFS) [HR = 0.87, 95%CI (0.71, 1.06), P = 0.17] were not significantly different between the PTR and non-PTR groups. In the subgroup analysis, all subgroups showed no significant difference in OS between the two groups. Conclusion PTR may not provide additional survival benefits over chemotherapy in asymptomatic, unresectable mCRC patients. However, in view of the limitations of this study, more well-designed RCTs are needed to validate our conclusions.
Loneliness is associated with unhealthful dietary behaviors and physical inactivity among US college students.

Objective: To evaluate dietary and physical activity behavior in relation to loneliness among college students. Participants: Three-hundred forty-six incoming first-year students in Fall 2019 at a large state University in the US. Methods: Students completed online surveys in Fall 2019. Multivariable regression analyses were used to model associations of health behaviors with loneliness, adjusting for gender and body mass index (BMI). Results: Two-hundred sixty-four students were included in this analysis. Students in loneliness score ranges of 4-6 and 7-9 have higher fat diet than students in score range of 10-12 (p = .007). Sedentary (19.2%) and low active (53.8%) behaviors were more frequent in students reporting high loneliness than those reporting low loneliness (13.8%, 36.7%, respectively) (p = .006). Conclusions: In this sample of college students, loneliness was related to altered diet quality and physical inactivity. Interventions to reduce loneliness may have a positive effect on health promotion in this population.
Brief Report: Child Sexual Abuse and Somatic Symptoms in Older Adulthood for Men

ABSTRACT Somatic symptom disorders are often misdiagnosed or minimized among men, especially in middle and older adulthood. Previous research investigating links between somatic disorders and early trauma, such as childhood sexual abuse (CSA), have mostly been based on small, non-representative, female samples using cross-sectional designs. The current study used data from the Wisconsin Longitudinal Study to assess associations between CSA and somatic symptom severity among men in middle- and late-adulthood (mid-50s to early 70s) with histories of CSA (n = 129) and a matched, non-abused comparison group (n = 2,322). Childhood (e.g., co-occurring adversities and parental education) and demographic background variables (e.g., marital status, self-rated health, and income) were controlled. Growth curve modeling was used to explore trajectories of somatic symptoms over time. Results indicated that the CSA group had higher somatic symptom severity than the non-abused group (γ01 = .10, p < .05); symptoms decreased over time for both groups with no significant differences in the rate of change. Healthcare providers should include CSA in assessments for men. Because contemporary somatic symptoms may represent unresolved early life course trauma, mental health support services should be expanded for this population. Future research should explore gender-appropriate treatment modalities for older men with histories of CSA.
Editing a gateway for cell therapy across the blood–brain barrier

Abstract Stem cell therapy has been shown to improve stroke outcomes in animal models and is currently advancing towards clinical practice. However, uncertainty remains regarding the optimal route for cell delivery to the injured brain. Local intracerebral injections are effective in precisely delivering cells into the stroke cavity but carry the risk of damaging adjacent healthy tissue. Systemic endovascular injections, meanwhile, are minimally invasive, but most injected cells do not cross CNS barriers and become mechanically trapped in peripheral organs. Although the blood–brain barrier and the blood–CSF barrier tightly limit the entrance of cells and molecules into the brain parenchyma, immune cells can cross these barriers especially under pathological conditions, such as stroke. Deciphering the cell surface signature and the molecular mechanisms underlying this pathophysiological process holds promise for improving the targeted delivery of systemic injected cells to the injured brain. In this review, we describe experimental approaches that have already been developed in which (i) cells are either engineered to express cell surface proteins mimicking infiltrating immune cells; or (ii) cell grafts are preconditioned with hypoxia or incubated with pharmacological agents or cytokines. Modified cell grafts can be complemented with strategies to temporarily increase the permeability of the blood–brain barrier. Although these approaches could significantly enhance homing of stem cells into the injured brain, cell entrapment in off-target organs remains a non-negligible risk. Recent developments in safety-switch systems, which enable the precise elimination of transplanted cells on the administration of a drug, represent a promising strategy for selectively removing stem cells stuck in untargeted organs. In sum, the techniques described in this review hold great potential to substantially improve efficacy and safety of future cell therapies in stroke and may be relevant to other brain diseases.
Modelling of electron beam absorption in complex geometries

Computational modelling of processes that involve highly energetic electrons like electron beam melting, welding, drilling or electron beam lithography, to name but a few, requires information about the attenuation of the electron beam as it passes through the sample. Depth–dose curves as a function of electron energy, target material as well as local surface obliquity have to be provided in situ during the calculation. The most efficient way to address this issue is by employing mathematical expressions. Therefore, we propose an electron beam model based on a set of semi-empirical equations available from different published literature and on theoretical considerations. Particular stress is thereby put on accuracy and the range of validity of the theoretical approach by comparison with experimental data. Finally, we apply our model to powder-bed based additive manufacturing. The numerical results demonstrate that electron beam absorption and depth of penetration have a strong influence on the quality of the fabricated product.
Newtonian quantum gravity

We develop a nonlinear quantum theory of Newtonian gravity consistent with an objective interpretation of the wavefunction. Inspired by the ideas of Schrodinger, and Bell, we seek a dimensional reduction procedure to map complex wavefunctions in configuration space onto a family of observable fields in space-time. Consideration of quasi-classical conservation laws selects the reduced one-body quantities as the basis for an explicit quasi-classical coarse-graining. These we interpret as describing the objective reality of the laboratory. Thereafter, we examine what may stand in the role of the usual Copenhagen observer to localise this quantity against macroscopic dispersion. Only a tiny change is needed, via a generically attractive self-potential. A nonlinear treatment of gravitational self-energy is thus advanced. This term sets a scale for all wavepackets. The Newtonian cosmology is thus closed, without need of an external observer. Finally, the concept of quantisation is re-interpreted as a nonlinear eigenvalue problem. To illustrate, we exhibit an elementary family of gravitationally self-bound solitary waves. Contrasting this theory with its canonically quantised analogue, we find that the given interpretation is empirically distinguishable, in principle. This result encourages deeper study of nonlinear field theories as a testable alternative to canonically quantised gravity.
Detection of 10 cases of ceftriaxone-resistant Neisseria gonorrhoeae in the United Kingdom, December 2021 to June 2022

Between December 2021 and June 2022, 10 cases of ceftriaxone-resistant Neisseria gonorrhoeae (ST8123; n = 8) were detected in the United Kingdom, compared with nine cases during the previous 6 years. Most of these cases were associated with travel from the Asia-Pacific region; all were heterosexual people, with most in their 20s. Although all cases were successfully treated, not all partners of cases could be traced, and there is a risk of further transmission of ceftriaxone-resistant gonococcal infection within the UK.
Microscopic anatomy of the oesophagus in the southern white‐breasted hedgehog (Erinaceus concolor) a histochemical, stereological, and scanning electron microscope study

The present work was designed to investigate the microscopic structure of the oesophagus in the southern white‐breasted hedgehog (Erinaceus concolor) using histochemical staining, Scanning electron microscope (SEM), and stereological procedures. Four adult males were included in our study. Serial sections of the entire length of the oesophagus were stained with aldehyde fuchsin, alcian blue (pH 2.5), Periodic acid Schiff (PAS), and Masson's trichrome. Then, the total volume of the oesophagus, and the total volume of its different layers, were estimated using Cavalieri's principle. The oesophageal epithelium was a non‐keratinized stratified squamous type. Muscularis mucosa was present as a thick layer between lamina propria and submucosa and its thickness was increased toward the stomach. Tunica submucosa was a loose connective tissue containing an oesophageal gland with PAS‐positive and AB‐positive reactions throughout the submucosa and become denser toward the stomach. The tunica muscularis consisted of two distinct striated muscle layers, and its thickness was decreased toward the stomach. On SEM images, the cervical and thoracic oesophagus showed shallow folding, while the abdominal part had deeper folds. The present findings indicate that the histological properties of the oesophagus in southern white‐breasted hedgehogs have slight similarities with rodents and considering its epithelium, submucosal glands and tunica muscularis more resemble with dog oesophagus. The obtained results may be quite helpful to improve the current knowledge of the histophysiology of the hedgehog gastrointestinal tract as a member of eulipotyplan mammals and as a pet for biologists and veterinarians.