Miracle-dz/UniFAR-FTUs huggingface dataset:
Uncoupling Proteins as Therapeutic Targets for Neurodegenerative Diseases

Most of the major retinal degenerative diseases are associated with significant levels of oxidative stress. One of the major sources contributing to the overall level of stress is the reactive oxygen species (ROS) generated by mitochondria. The driving force for ROS production is the proton gradient across the inner mitochondrial membrane. This gradient can be modulated by members of the uncoupling protein family, particularly the widely expressed UCP2. The overexpression and knockout studies of UCP2 in mice have established the ability of this protein to provide neuroprotection in a number of animal models of neurological disease, including retinal diseases. The expression and activity of UCP2 are controlled at the transcriptional, translational and post-translational levels, making it an ideal candidate for therapeutic intervention. In addition to regulation by a number of growth factors, including the neuroprotective factors LIF and PEDF, small molecule activators of UCP2 have been found to reduce mitochondrial ROS production and protect against cell death both in culture and animal models of retinal degeneration. Such studies point to the development of new therapeutics to combat a range of blinding retinal degenerative diseases and possibly other diseases in which oxidative stress plays a key role.
Service Orientation, Integrity and Commitment to Students; Administrative Performance Management in Madrasah

This study aims to understand service orientation, integrity, and commitment in the performance management system of the head of administration within the scope of students in Madrasah Aliyah Negeri in Lampung Province. This study uses a phenomenological qualitative approach, where the researcher uses interviews, observations, and documentation to obtain data. The data analysis refers to the interactive data analysis model from Milles & Huberman, namely data reduction, data presentation, conclusion drawing, and verification. The results showed that service orientation, integrity, and commitment in the administrative performance management system at Madrasah Aliyah Negeri Lampung Province were carried out in a planned and systematic way through various varied activities to be able to provide good service to students. This research has implications for improving the quality of administrative resources in providing optimal services to students and stakeholders.
The evaluation of disease awareness, caregiver burden, and workday loss in caregivers of COPD patients

Background/aim Our aim is to determine the caregiver burden of chronic obstructive lung disease (COPD) patient’s caregivers, and to determine whether there is a workday loss. Materials and methods 252 COPD patients and their caregivers were included. Disease information of the patients were recorded and a questionnaire was applied. Socio-demographic characteristics of the caregivers were recorded and a questionnaire consisting of 24 questions including COPD disease, treatment and loss of working days, and the Zarit Scale were used. Results 128(50.8%) of the patients according to GOLD were group-D, 97(38.5%) of the patient’s relatives were working, 62(24.7%) were not able to go to work for 1–14 days, and 125(57.1%) spent outside the home from 1–14 nights, because those accompanied to patients. In univariate analysis were detected modified medical research council (mMRC) (p < 0.001), CAT (p < 0.001), the number of comorbidities of patients (p = 0.027), forced expiratory volume in 1 FEV1cc (p = 0.009), FEV1% (p < 0.001), the presence of long term oxygen therapy (LTOT), and the number of comorbidities of the patient’s relatives (p = 0.06) increased the care load. In multiple linear regression analysis, age (p = 0.03), COPD assessment test (CAT) score (p = 0.001), FEV1% (<0.068) and the number of comorbidities of patients (p = 0.01) and the number of comorbidities of caregivers (p = 0.003) increased the caregiving burden. Conclusion In COPD increases caregiving burden. This burden is greater in symptomatic patients and when comorbidities are present. Psychosocial and legal regulations should be investigated and solutions should be produced for the caregivers of COPD patients.
Expression Analysis of Genes Involved in Transport Processes in Mice with MPTP-Induced Model of Parkinson’s Disease

Processes of intracellular and extracellular transport play one of the most important roles in the functioning of cells. Changes to transport mechanisms in a neuron can lead to the disruption of many cellular processes and even to cell death. It was shown that disruption of the processes of vesicular, axonal, and synaptic transport can lead to a number of diseases of the central nervous system, including Parkinson’s disease (PD). Here, we studied changes in the expression of genes whose protein products are involved in the transport processes (Snca, Drd2, Rab5a, Anxa2, and Nsf) in the brain tissues and peripheral blood of mice with MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine)-induced models of PD. We detected changes in the expressions of Drd2, Anxa2, and Nsf at the earliest modeling stages. Additionally, we have identified conspicuous changes in the expression level of Anxa2 in the striatum and substantia nigra of mice with MPTP-induced models of PD in its early stages. These data clearly suggest the involvement of protein products in these genes in the earliest stages of the pathogenesis of PD.
Application of Osimertinib for Non-Small Cell Lung Cancer: In Patients with Untreated Central Nervous System Metastasis

: Power load forecasting is very important for power dispatching. Accurate load forecasting is of great significance for saving energy, reducing generating cost and improving social and economic benefits. In order to accurately predict the power load, based on BP neural network theory, combined with the advantages of Clementine in dealing with big data and preventing overfitting, a neural network prediction model for large data is constructed.
Is it possible to predict mortality and recurrence of VT afterablation? PAINESD risk score applicability vs new predictors

Type of funding sources: None. Catheter ablation (CA) prevents ventricular tachycardia (VT) recurrences in patients (pts) with structural heart disease (SHD), and might have a favorable outcome, but is associated with severe short-term complications. Identification of pts at high risk of periprocedural acute haemodynamic decompensation has important implications at procedural planning. The PAINESD risk score is a promising tool to predict VT ablation procedure-related mortality. To evaluate the accuracy of the PAINESD risk score to predict short-term mortality after structural VT ablation and to compare it with other conventional clinical predictors. Prospective, observational, single-centre study of consecutive pts with SHD (ischemic or nonischemic), referred for VT-CA. High-density substrate maps were collected, through endocardial, epicardial or combined endo-epicardial approaches according to clinical data and operator preference. The primary endpoint was 30-day mortality or hemodynamic decompensation. Univariate Cox regression analysis was used to identify relevant clinical predictors and to compare them with the PAINESD risk score. Multivariable Cox proportional hazards regression models were used to estimate predictors of 30-day mortality. A total of 102 pts with SHD referred for VT ablation were evaluated(mean age: 67±11 years, 94% male, 78.4% in NYHA class I-II; mean LVEF was 34±11%). The baseline PAINESD risk score was 12.39±5.8, 19.6% at low risk, 36.3% at intermediate risk and 27.5% at high risk of adverse events. Overall 30-day mortality was 4.9%. The PAINESD did not predict 30-days mortality or hemodynamic decompensation (p= 0.93). Indeed, a non- significant trend to higher short and long-term mortality was noticed in high-risk score pts – Figure 1. On univariate analysis age>65 years (p=0.019), LVEF <35% (p=0.049), body mass index<28kg/m2 (p=0.019), CKD (p=0.001) and previous VT ablation (p=0.022) were prognostic predictors. On multivariate analysis, only LVEF<35% (HR2.225; CI95% 1.004-4-774,p=0.038) and CKD (HR 3.35; CI95%: 1.31-8.51, p=0.011) were independent predictors of short-term prognosis. In our population, LVEF<35% and CKD were the strongest predictors of short-term mortality. PAINESD risk score was not accurate in predicting adverse events. New score systems must be derived for prognostic stratification in this population, incorporating the reduction on the actual short-term event rates after VT ablation.
The impact of Fusarium mycotoxins on macro and micro parameters of dairy cattle

Recommended Citation FALKAUSKAS, RIMVYDAS; BAKUTIS, BRONIUS; JOVAISIENE, JURGITA; VAICIULIENE, GINTARE; GERULIS, GEDIMINAS; ZELVYTE, RASA; BARTKIENE, ELENA; SILINSKAS, IGNAS; KLEMENTAVICIUTE, JOLITA; and BALIUKONIENE, VIOLETA (2022) "The impact of Fusarium mycotoxins on macro and micro parameters of dairy cattle," Turkish Journal of Veterinary & Animal Sciences: Vol. 46: No. 2, Article 19. https://doi.org/ 10.55730/1300-0128.4182 Available at: https://journals.tubitak. gov.tr/veterinary/vol46/iss2/19
Minimally Invasive Distal Chevron Osteotomy for Symptomatic Bunionette: Clinical and Radiologic Results of a 31-Case Retrospective Study

Background: Bunionette is a common forefoot deformity that usually leads to significant discomfort. Multiple surgical techniques have been described for correcting bunionette. The purpose of this study is to analyze the clinical and radiologic outcomes of a new surgical technique via minimally invasive distal Chevron osteotomy of the fifth metatarsal without fixation, trying to find an effective technique with fewer complications. Methods: We retrospectively analyzed the data of 28 patients (31 feet) who presented with symptomatic bunionette that was resistant to conservative treatment and who underwent surgery at our center from February 2018 to February 2020. A minimum follow-up of 20 months was obtained (mean follow-up 26 months, range 20–37). Clinical results were evaluated using the visual analog scale (VAS) and the American Orthopaedic Foot & Ankle Society (AOFAS) score; 5 different radiologic parameters were analyzed. Results: After surgery, the mean AOFAS score increased by 29 points (P < .001) and the mean VAS scores decreased by 6 points (P < .001). An adequate radiologic correction was observed with a decrease in the M4–M5 intermetatarsal angle from 10.3 to 4.8 degrees (P < .001), metatarsophalangeal angle by a mean of 16.05 degrees (P < .001), and lateral deviation angle of the fifth metatarsal from 8.5 to 0.97 degrees (P < .001). Moreover, the length of the fifth metatarsal and the forefoot width was reduced (P < .001). The only complication was an asymptomatic delay in bone healing, but a complete bone consolidation was achieved after therapy. Conclusion: The proposed surgical technique shows a good correction capacity with excellent clinical and radiologic results and low complication rates. Level of Evidence: Level IV, retrospective case series.
Distribution and molecular differentiation of Culex pipiens complex species in theMiddle and Eastern Black Sea Regions of Turkey

Recommended Citation AKINER, MUHAMMET MUSTAFA; ÖZTÜRK, MURAT; BERİŞ, FATİH ŞABAN; KARACAOĞLU, ÇAĞAŞAN; ŞİMŞEK, FATİH MEHMET; and AKGEYİK, AYTÜL UZUN (2022) "Distribution and molecular differentiation of Culex pipiens complex species in theMiddle and Eastern Black Sea Regions of Turkey," Turkish Journal of Zoology: Vol. 46: No. 2, Article 4. https://doi.org/10.55730/1300-0179.3049 Available at: https://journals.tubitak. gov.tr/zoology/vol46/iss2/4
A review of the predictive methods for arteriovenous fistula (AVF) failure identification

ABSTRACT The arteriovenous fistula (AVF) is the optimal form of vascular access for end-stage renal failure patients requiring haemodialysis. However, AVFs can fail to mature into a useable conduit or develop recurrent stenoses that result in high surgical re-intervention rates to maintain patency. Here, we performed a narrative review of literature on methods of AVF failure identification such as clinical prediction models, shear stress metrics characterisation with 0D, 1D and 3D computational models and blood flow sound frequency. Clinical risk factors identified by a clinical scoring system fail to predict ongoing AVF status and patency rate. The pulse wave propagation model, although showed positive prospect to support surgical planning, has limited ability in blood flow volume prediction in the anastomotic region. Shear stress metrics were one of the most common indicators to understand flow behaviours in AVF. While transverse wall shear stress seemed promising in characterising multidirectional flow in an AVF, no definitive correlations between shear stress metrics and disease initialisation have been reported. We conclude that further assessment is required to develop a clinical diagnostic marker for AVF failure prediction as no definitive prediction indicator was proposed even though there is an apparent impact of haemodynamic factors in AVF failure.
Biogenic synthesis of gold nanoparticles using red seaweed Champia parvula and its anti-oxidant and anticarcinogenic activity on lung cancer

Abstract The biocompatible gold nanoparticles (AuNPs) have great potential in the development of next-generation anti-cancer medicine. Here, AuNPs were synthesized through a biogenic method using the red marine algae Champia parvula. The synthesized Cp-AuNPs were characterized and confirmed by various spectroscopic techniques. The UV spectroscopy analysis found the Cp-AuNPs Surface Plasmon Resonance (SPR) peak at 550 nm. The accurate size and morphology of Cp-AuNPs were identified by Transmission Electron Microscope (TEM) and Scanning Electron Microscope (SEM) analysis were found to be 20 nm in size and round in shape. The crystal nature of Cp-AuNPs was confirmed by X-ray Diffraction (XRD) spectrum. The FTIR analytical tool was used to determine the presence of organic compounds in the algae extract and synthesized Cp-AuNPs. The biogenic Cp-AuNPs showed excellent anti-oxidant and free radical scavenging ability due to the presence of anti-oxidant-rich components. Anti-cancer activity of Cp-AuNPs was investigated on lung cancer (A549) cells and demonstrated high anti-cancer potential. Our findings suggested that synthesized Cp-AuNPs have a significant therapeutic ability for lung cancer.
An Examination of the Causality Between Export, Import and Economic Growth of Kosovo Using Quarterly Data From 2010 to 2021

The aim of this paper is to examine the nexus between exports, imports, and economic growth for the Kosovo’s economy in the period 2010-2021. Unit root tests were used to test the stationarity condition. The ADF, P-P and KPSS tests showed that the three variables are stationary in the first difference. The Johansen cointegration test showed that these variables are cointegrated in the short run. The lag length was set to five based on three criteria. The proposed model was free of serial autocorrelation and heteroskedasticity. Granger causality results based on Vector Autoregression showed that there is a bidirectional causality relationship between exports and economic growth. There is no causality between imports and economic growth. However, there is unidirectional causality from economic growth to imports and unidirectional causality from exports to imports. This study supports the ELG theory, i.e., exports are an important driver of economic growth.
A marble Sarcophagus of Gadara (Umm Qais), Jordan: insights on its provenance

This research investigates the archaeometric characteristics of the marble sarcophagus displayed in the Umm Qeis Museum of Antiquities, Gadara (Umm Qais), north Jordan. Marble sarcophagi are very rarely found at archaeological sites in Jordan; the Gadara marble sarcophagus is, therefore, unique. This sarcophagus, dated to the 3rd century AD, presents only the base and the lid; the lid shows remnants and traces of the chiton and himation of two effigies, while the pedestal shows remnants of a foot and a weapon, both probably indicate an Attic sarcophagus. The research undertaken aims to determine the quarry origins of the box and the lid, while also considering the notion of some scholars that the boxes of Attic sarcophagi were carved of Pentelic marble, while the lids were carved of Hymettian marble. The results of the mineralogical, petrographic, chemical and isotopic analyses showed that the most likely quarry origin of the two marble parts is Pentelikon Mountain, Athens, Greece. The sarcophagus’s high quality, elaborate decorations, large volume and heavy weight, along with the inland location of Gadara, suggest that it was ordered by a wealthy and/or a high-status Gadarene citizen.
Dietary phytochemical consumption is inversely associated with liver alkaline phosphatase in Middle Eastern adults

BACKGROUND The hepatoprotective effects of phytochemicals are controversial. A dietary phytochemical index (DPI) has been suggested as an alternative method for quantifying the phytochemical content of foods. AIM To assess the DPI in relation to liver function tests among a representative sample of Iranian adults. METHODS A total of 5111 participants aged 35-70 years old were included in this cross-sectional study by a multistage cluster random sampling method. Dietary intakes were collected by a validated and reliable food frequency questionnaire with 121 items. DPI was calculated by the percent of daily energy intake taken from phytochemical-rich foods. Fasting serum concentrations of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) and gamma glutamyl transferase (GGT) were determined. Linear regression was used to investigate the association between DPI and levels of liver enzymes using crude and adjusted models. RESULTS There was an inverse association between DPI score and serum ALP in the crude model (β = -0.05; P < 0.001). This association remained significant after adjustment for body mass index, age, smoking, energy intake, history of diabetes, and education (β = -0.03; P = 0.01). No significant associations were found between DPI score and serum levels of AST, ALT, and GGT. The individuals with the highest DPI scores consumed significantly higher amounts of fruits, vegetables, legumes, nuts, and cereals, yet were shown to have significantly higher serum total cholesterol and low-density lipoprotein cholesterol, as well as several other metabolic abnormalities. CONCLUSION Higher adherence to phytochemical-rich foods was associated with lower levels of ALP, but no change in other liver enzymes. Those with higher DPI scores also consumed food items associated with a healthier overall dietary pattern; however, they also presented several unexpected metabolic derangements. Additional randomised trials are needed to better determine the effects of phytochemical-rich foods on liver function.
Fracture stratigraphy of Mesozoic platform carbonates, Agri Valley, southern Italy

Abstract The Viggiano Mt. platform carbonates form a layered succession cross-cut by a dense array of pressure solution seams, and five sets of fractures and veins, which together form a sub-seismic structural network associated with polyphasic tectonic evolution. To assess the influence exerted by depositional and diagenetic heterogeneities on fracture geometry, distribution and multiscale properties, we present the results of stratigraphic, petrographic, mineralogical and mesoscale structural analyses conducted at the Viggiano Mountain, southern Italy. Based on rock textures and fossil associations, we documented that the Sinemurian–Pleinsbachian carbonates were deposited in a low-energy open lagoon, the Toarcian carbonates in a ramp setting rimmed by sand shoals, and the Cenomanian carbonates in a medium- to high-energy, lagoonal–tidal setting. Fracture-density (P20) and intensity (P21) values computed after circular scanline measurements show similar trends in both Sinemurian–Pleinsbachian and Toarcian carbonates, consistent with the bed and bed-package heterogeneities acting as efficient mechanical interfaces during incipient faulting. On the other hand, P20 and P21 do not show very similar variations throughout the Cenomanian carbonates due to pronounced bed amalgamation. Throughout the study area, the aforementioned parameters do not vary in proportion to the bed thickness, and show higher values within the coarse-grained carbonate beds. This conclusion is confirmed by results of linear scanline measurements, which focus on the P10 properties of the most common diffuse fracture set. The original results reported in this work are consistent with burial-related, physical–chemical compaction and cementation processes affecting the fracture stratigraphy of the Mesozoic platform carbonates.
Modulating the Growth, Antioxidant Activity, and Immunoexpression of Proinflammatory Cytokines and Apoptotic Proteins in Broiler Chickens by Adding Dietary Spirulina platensis Phycocyanin

This study investigated the dietary effect of Spirulina platensis phycocyanin (SPC) on growth performance (body weight (BW), body weight gain (BWG), feed intake (FI), feed conversion ratio (FCR)) at starter, grower, and finisher stages, intestinal histomorphology, serum biochemical parameters, inflammatory and antioxidant indices, and proinflammatory cytokines (tumor necrosis factor-α and caspase-3) immune expression in broiler chickens. In total, 250 one-day-old chicks (Ross 308 broiler) were randomly allotted to five experimental groups (5 replicates/group, 10 chicks/replicate) and fed basal diets supplemented with five levels of SPC (0, 0.25, 0.5, 0.75, and 1 g kg–1 diet) for 35 days. Compared with SPC0 treatment, different SPC levels increased the overall BW and BWG without affecting the total feed consumption. However, the FCR decreased linearly with an increase in supplementation level. The serum levels of total proteins, albumin, globulins, and growth hormone increased linearly by increasing levels of SPC supplementation. Further, SPC supplementation increased the thyroxin hormones without affecting serum glucose and leptin levels. Serum total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) values decreased in broilers fed SPC0.250 and SPC1 diets. Triglycerides (TG) decreased in SPC0.25-, SPC0.75-, and SPC1-treated groups. Though antioxidant enzyme activities (total antioxidant capacity, catalase, and superoxide dismutase) increased linearly and quadratically, malondialdehyde (MDA) decreased linearly by increasing the SPC level. There was no effect on serum proinflammatory cytokines IL1β levels. Immunolabelling index of caspase-3 and tumor necrosis factor-α (TNF-α) were downregulated by SPC supplementation. The intestinal histomorphology is represented by increased villus height, the villus height to crypt depth ratio, and numbers of goblet cells in different sections of the small intestine. In conclusion, SPC supplementation is beneficial in broiler chicken diets due to its growth-promoting, antioxidant, and anti-inflammatory properties.