Miracle-dz/UniFAR-FTUs huggingface dataset:
Depleted Calcium Stores and Increased Calcium Entry in Rod Photoreceptors of the Cacna2d4 Mouse Model of Cone-Rod Dystrophy RCD4

Unidentified pathogenetic mechanisms and genetic and clinical heterogeneity represent critical factors hindering the development of treatments for inherited retinal dystrophies. Frameshift mutations in Cacna2d4, which codes for an accessory subunit of voltage-gated calcium channels (VGCC), cause cone-rod dystrophy RCD4 in patients, but the underlying mechanisms remain unknown. To define its pathogenetic mechanisms, we investigated the impact of a Cacna2d4 frameshift mutation on the electrophysiological profile and calcium handling of mouse rod photoreceptors by patch-clamp recordings and calcium imaging, respectively. In mutant (MUT) rods, the dysregulation of calcium handling extends beyond the reduction in calcium entry through VGCC and surprisingly involves internal calcium stores’ depletion and upregulation of calcium entry via non-selective cationic channels (CSC). The similar dependence of CSC on basal calcium levels in WT and MUT rods suggests that the primary defect in MUT rods lies in defective calcium stores. Calcium stores’ depletion, leading to upregulated calcium and sodium influx via CSC, represents a novel and, so far, unsuspected consequence of the Cacna2d4 mutation. Blocking CSC may provide a novel strategy to counteract the well-known pathogenetic mechanisms involved in rod demise, such as the reticulum stress response and calcium and sodium overload due to store depletion.
VVV-WIT-07: another Boyajian’s star or a Mamajek’s object?

We report the discovery of VVV-WIT-07, an unique and intriguing variable source presenting a sequence of recurrent dips with a likely deep eclipse in July 2012. The object was found serendipitously in the near-IR data obtained by the VISTA Variables in the V\'ia L\'actea (VVV) ESO Public Survey. Our analysis is based on VVV variability, multicolor, and proper motion (PM) data. Complementary data from the VVV eXtended survey (VVVX) as well as archive data and spectroscopic follow-up observations aided in the analysis and interpretation of VVV-WIT-07. A search for periodicity in the VVV Ks-band light curve of VVV-WIT-07 results in two tentative periods at P~322 days and P~170 days. Colors and PM are consistent either with a reddened MS star or a pre-MS star in the foreground disk. The near-IR spectra of VVV-WIT-07 appear featureless, having no prominent lines in emission or absorption. Features found in the light curve of VVV-WIT-07 are similar to those seen in J1407 (Mamajek's object), a pre-MS K5 dwarf with a ring system eclipsing the star or, alternatively, to KIC 8462852 (Boyajian's star), an F3 IV/V star showing irregular and aperiodic dips in its light curve. Alternative scenarios, none of which is fully consistent with the available data, are also briefly discussed, including a young stellar object, a T Tauri star surrounded by clumpy dust structure, a main sequence star eclipsed by a nearby extended object, a self-eclipsing R CrB variable star, and even a long-period, high-inclination X-ray binary.
Are star formation rates of galaxies bimodal

Star formation rate (SFR) distributions of galaxies are often assumed to be bimodal with modes corresponding to star-forming and quiescent galaxies, respectively. Both classes of galaxies are typically studied separately, and SFR distributions of star-forming galaxies are commonly modelled as lognormals. Using both observational data and results from numerical simulations, I argue that this division into star-forming and quiescent galaxies is unnecessary from a theoretical point of view and that the SFR distributions of the whole population can be well fitted by zero-inflated negative binomial distributions. This family of distributions has three parameters that determine the average SFR of the galaxies in the sample, the scatter relative to the star-forming sequence and the fraction of galaxies with zero SFRs, respectively. The proposed distributions naturally account for (i) the discrete nature of star formation, (ii) the presence of ‘dead’ galaxies with zero SFRs and (iii) asymmetric scatter. Excluding ‘dead’ galaxies, the distribution of log SFR is unimodal with a peak at the star-forming sequence and an extended tail towards low SFRs. However, uncertainties and biases in the SFR measurements can create the appearance of a bimodal distribution.
Trans-Arterial Chemoembolization Plus Systemic Treatments for Hepatocellular Carcinoma: An Update

Recent years have seen the advent of novel treatment options for hepatocellular carcinoma (HCC). Given a strong biological rationale supporting this strategy, multiple studies have explored the role of combination treatments including locoregional plus systemic therapies to produce a synergistic effect and enhance antitumor activity. Among locoregional therapies, several clinical trials assessing trans-arterial chemoembolization (TACE) have been recently presented and published. In the current paper, we discuss available evidence and current and future research on combined TACE and systemic treatments, including antiangiogenic agents, immune checkpoint inhibitors, and immune-based combinations for HCC patients.
New Well-Preserved Materials of Glossotherium chapadmalense (Xenarthra, Mylodontidae) from the Pliocene of Argentina Shed Light on the Origin and Evolution of the Genus

ABSTRACT Fossil remains of extinct mylodontine sloths have been discovered in numerous localities throughout the American supercontinent, but knowledge of them is still mainly centered on the Pleistocene forms rather than their Neogene relatives. In this contribution, previously unpublished cranial and postcranial materials herein ascribed to Glossotherium chapadmalense (Kraglievich), coming from the Pliocene Chapadmalal Formation (Province of Buenos Aires, Argentina), are presented. These remains are described and compared with those of other mylodontine species from South and North America, providing an exhaustive characterization of cranial morphology in G. chapadmalense and some preliminary insights into its postcranial anatomy. The results have revealed a unique combination of differences and similarities of this enigmatic species with the larger-sized representatives of Glossotherium. In addition, these materials allowed shedding light on the long-standing uncertainties regarding its taxonomic status, as this form has been alternately considered to belong to the genera Glossotherium or Glossotheridium over the last century. As a result, the genus Glossotherium was present, at least, at the Early–Late Pliocene transition in the Pampean region of Argentina, and is recorded by the Upper Pleistocene throughout the entire South American continent. The radiation of the Pleistocene species is associated with a consistent body mass increase that was probably a response to the cooling temperatures and higher predation pressure in South America during the Late Pliocene–Early Pleistocene. These phenomena were probably driven by the stable emergence of the Panamanian Isthmus around 3 Ma and the successive faunal turnover pulses of the Great American Biotic Interchange.
Export Led Industrialization and Gender Differences in Job Creation and Destruction: Micro Evidence from The Turkish Manufacturing Sector

In this paper we investigate gender differences in job creation and destruction patterns in Turkey during a period of substantial trade liberalization. The primary findings are as follows. 1) In the manufacturing sector as a whole, net job creation rate for females at every skill level are significantly higher than their male counterparts. 2) Gross job reallocation rate for females is about twice the size of males at the same skill levels. 3) Net job creation rates in the exportable sector are higher than they are in the import competing sectors for all worker groups. However, the net job creation rate for female production workers (non-production) relative to their male counterparts is higher (lower) in the import-competing sector than it is in the exportable sector. Since female production (non-production) workers constitute a smaller (larger) share of employees in import competing sectors, the results indicate that the relative net job creation rate for females are higher where females constitute a smaller fraction of the workforce. 4) The ratio of gross job reallocation rate of females to males at a given skill level differ only slightly across sectors by trade orientation.
ApoE3 vs. ApoE4 Astrocytes: A Detailed Analysis Provides New Insights into Differences in Cholesterol Homeostasis

The strongest genetic risk factor for sporadic Alzheimer’s disease (AD) is the presence of the ε4 allele of the apolipoprotein E (ApoE) gene, the major apolipoprotein involved in brain cholesterol homeostasis. Being astrocytes the main producers of cholesterol and ApoE in the brain, we investigated the impact of the ApoE genotype on astrocyte cholesterol homeostasis. Two mouse astrocytic cell lines expressing the human ApoE3 or ApoE4 isoform were employed. Gas chromatography–mass spectrometry (GC-MS) analysis pointed out that the levels of total cholesterol, cholesterol precursors, and various oxysterols are altered in ApoE4 astrocytes. Moreover, the gene expression analysis of more than 40 lipid-related genes by qRT-PCR showed that certain genes are up-regulated (e.g., CYP27A1) and others down-regulated (e.g., PPARγ, LXRα) in ApoE4, compared to ApoE3 astrocytes. Beyond confirming the significant reduction in the levels of PPARγ, a key transcription factor involved in the maintenance of lipid homeostasis, Western blotting showed that both intracellular and secreted ApoE levels are altered in ApoE4 astrocytes, as well as the levels of receptors and transporters involved in lipid uptake/efflux (ABCA1, LDLR, LRP1, and ApoER2). Data showed that the ApoE genotype clearly affects astrocytic cholesterol homeostasis; however, further investigation is needed to clarify the mechanisms underlying these differences and the consequences on neighboring cells. Indeed, drug development aimed at restoring cholesterol homeostasis could be a potential strategy to counteract AD.
Manifestations of the $a^0_0(980)-f_0(980)$ mixing in $D^0\to K^0_S\pi^+\pi^-$ and $D^0\to K^0_S\eta\pi^0$ decays

Possible manifestations of the isospin-breaking mixing of the $a^0_0(980)$ and $f_0(980)$ resonances are analyzed in the $D^0\to K^0_S \pi^+\pi^-$ and $D^0\to K^0_S\eta\pi^0$ decays. It is shown that the $a^0_0(980)-f_0(980)$ mixing has the most influence on the $\pi^+\pi^-$ mass spectrum in the decay $D^0\to K^0_S\pi^+\pi^-$. Owing to the $a^0_0(980)-f_0(980)$ mixing, the $f_0(980)$ peak in $D^0 \to K^0_Sf_0(980)\to K^0_S \pi^+\pi^-$ can experience distortions comparable with its size. The effect essentially depends on the relative phase between the amplitudes of the $D^0\to K^0_Sf_0(980)$ and $D^0\to K^0_Sa^0_0(980)$ transitions.
Spontaneous and stimulated radiative emission of modulated free-electron quantum wavepackets—semiclassical analysis

Here we present a semiclassical analysis of spontaneous and stimulated radiative emission from unmodulated and optically-modulated free-electron quantum wavepackets. We show that the radiative emission/absorption and corresponding deceleration/acceleration of the wavepackets depend on the controllable ‘history-dependent’ wavepacket size. The characteristics of the radiative interaction when the wavepacket size (duration) is short relative to the radiation wavelength, are close to the predictions of the classical point-particle modelling. On the other hand, in the long-sized wavepacket limit, the interaction is quantum-mechanical, and it diminishes exponentially at high frequency. We exemplify these effects through the scheme of Smith-Purcell radiation, and demonstrate that if the wavepacket is optically-modulated and periodically-bunched, it exhibits finite radiative emission at harmonics of the modulation frequency beyond the limit of high-frequency cutoff. Besides, the radiation analysis is further extended to the cases of superradiant emission from a beam of phase-correlated modulated electron wavepackets. The features of the wavepacket-dependent radiative emission explain the classical-to-quantum transition, and indicate a way for measuring the quantum electron wavepacket size. This suggests a new direction for exploring light–matter interaction.
A surface temperature dipole pattern between Eurasia and North America triggered by the Barents–Kara sea-ice retreat in boreal winter

The Arctic has experienced dramatic climate changes, characterized by rapid surface warming and sea-ice loss over the past four decades, with broad implications for climate variability over remote regions. Some studies report that Arctic warming may simultaneously induce a widespread cooling over Eurasia and frequent cold events over North America, especially during boreal winter. In contrast, other studies suggest a seesaw pattern of extreme temperature events with cold weather over East Asia accompanied by warm weather in North America on sub-seasonal time scales. It is unclear whether a systematic linkage in surface air temperature (SAT) exists between the two continents, let alone their interaction with Arctic sea ice. Here, we reveal a dipole pattern of SAT in boreal winter featuring a cooling (warming) in the Eurasian continent accompanied by a warming (cooling) in the North American continent, which is induced by an anomalous Barents–Kara sea-ice decline (increase). The dipole operates on interannual and multidecadal time scales. We find that an anomalous sea-ice loss over the Barents–Kara Seas triggers a wavenumber one atmospheric circulation pattern over the high-latitude Northern Hemisphere, with an anomalous high-pressure center over Siberia and an anomalous low-pressure center over high-latitude North America. The circulation adjustment generates the dipole temperature pattern through thermal advection. Our finding has important implications for Northern Hemisphere climate variability, extreme weather events, and their prediction and projection.
Sphalerons, merons, and unstable branes in AdS space

We construct unstable classical solutions of Yang-Mills theories and their dual unstable states of type IIB on AdS_5. An example is the unstable D0-brane of type IIB located at the center of AdS. This has a field theory dual which is a sphaleron in gauge theories on S^3 x R. We argue that the two are dual because both are sphalerons associated to the topology of the instanton/D-instanton. This agreement provides a non-supersymmetric test of the AdS/CFT duality. As an illustration, many aspects of Sen's hypothesis regarding the unstable branes can be seen easily in the weakly coupled dual field theory description. In Euclidean AdS the D0-branes are dual to gauge theory merons. This implies that the two ends of a D0-brane world-line carry half the charge of a D-instanton. Other examples involve unstable strings in the Coulomb phase.
The Wooldridge Method for the Initial Values Problem is Simple: What About Performance?

The Wooldridge method is based on a simple and novel strategy to deal with the initial values problem in the nonlinear dynamic random-effects panel data models. This characteristic of the method makes it very attractive in empirical applications. However, its finite sample performance is not known as of yet. In this paper we investigate the performance of this method in comparison with an ideal case in which the initial values are known constants, the worst scenario based on exogenous initial values assumption, and the Heckman's reduced-form approximation method which is widely used in the literature. The dynamic random-effects probit and tobit (type1) models are used as the working examples. Various designs of Monte Carlo Experiments with balanced and unbalanced panel data sets, and also two full length empirical applications are provided. The results suggest that the Wooldridge method works very well for the panels with moderately long durations (longer than 5-8 periods). In short panels Heckman's reduced-form approximation is suggested (shorter than 5 periods). It is also found that all methods perform equally well for panels of long durations (longer than 10-15 periods).
Nonlinear Earthquake Response of Marine Sediments With Distributed Acoustic Sensing

Soft sediment layers can significantly amplify seismic waves from earthquakes. Large dynamic strains can trigger a nonlinear response of shallow soils with low strength, which is characterized by a shift of resonance frequencies, ground motion deamplification, and in some cases, soil liquefaction. We investigate the response of marine sediments during earthquake ground motions recorded along a fiber‐optic cable offshore the Tohoku region, Japan, with distributed acoustic sensing (DAS). We compute AutoCorrelation Functions (ACFs) of the ground motions from 105 earthquakes in different frequency bands. We detect time delays in the ACF waveforms that are converted to relative velocity changes (dv/v). dv/v drops, which characterize soil nonlinearity, are observed during the strongest ground motions and exhibit a large variability along the cable. This study demonstrates that DAS can be used to infer the dynamic properties of the shallow Earth with an unprecedented spatial resolution.
Diagnostic value and safety of endobronchial ultrasonography with a guide sheath transbronchial biopsy for diagnosing peripheral pulmonary lesions in patients with interstitial lung disease

Background Radial endobronchial ultrasonography transbronchial biopsy with and without a guide sheath is a useful method for diagnosing peripheral pulmonary lesions (PPLs). However, the diagnostic yield and complications of radial endobronchial ultrasonography transbronchial biopsy for PPLs remains elusive in patients with interstitial lung disease (ILD). Methods We retrospectively analysed 431 patients (69 with and 362 without ILD) who underwent radial endobronchial ultrasonography with a guide sheath transbronchial biopsy (EBUS-GS TBB) for PPLs from April 1, 2011, to March 31, 2020. We investigated the diagnostic yield and complications of the procedure for PPLs and compared them between patients with and without ILD. We also evaluated the factors contributing to successful diagnosis. Results The diagnostic yield of radial endobronchial ultrasonography in patients with ILD was significantly lower than in those without ILD (62.3% vs. 75.4%, P=0.024). Multivariate analysis showed that the presence of ILD as background lung [odds ratio (OR) =0.517], probe position within the lesion (OR =4.654), and the presence of solid lesion (OR =1.946) significantly affected the diagnostic yield of PPLs. There was a significant difference in the rate of pneumothorax between the patients with ILD and those without ILD (4.3% vs. 0.6%, P=0.031). Conclusions The presence of ILD as the background lung significantly affected the diagnostic yield of PPLs with radial EBUS-GS TBB. Regarding the complications, pneumothorax occurred more frequently in patients with ILD than in those without ILD.
THE RADIAL DISTRIBUTIONS OF THE TWO MAIN-SEQUENCE COMPONENTS IN THE YOUNG MASSIVE STAR CLUSTER NGC 1856

The recent discovery of double main sequences in the young, massive star cluster NGC 1856 has caught significant attention. The observations can be explained by invoking two stellar generations with different ages and metallicities or by a single generation of stars composed of two populations characterized by different rotation rates. We analyzed the number ratios of stars belonging to both main-sequence components in NGC 1856 as a function of radius. We found that their number ratios remain approximately unchanged from the cluster’s central region to its periphery, indicating that both components are homogeneously distributed in space. Through a comparison of the loci of the best-fitting isochrones with the ridge lines of both stellar components, we found that both multiple stellar populations and rapid stellar rotation can potentially explain the observed main-sequence bifurcation in NGC 1856. However, if NGC 1856 were a young representative of the old globular clusters, then the multiple stellar populations model would not be able to explain the observed homogeneity in the spatial distributions of these two components, since all relevant scenarios would predict that the second stellar generation should be formed in a more compact configuration than that of the first stellar generation, while NGC 1856 is too young for both stellar generations to have been fully mixed dynamically. We speculate that the rapid stellar rotation scenario would be the favored explanation of the observed multiple stellar sequences in NGC 1856.
Assessment of the Proximity of the Inferior Alveolar Canal with the Mandibular Root Apices and Cortical Plates—A Retrospective Cone Beam Computed Tomographic Analysis

Various endodontic interventions often lead to iatrogenic damage to the inferior alveolar nerve present in the inferior alveolar canal (IAC). The purpose of the present study was to analyze the relationships of IAC with the root apices of mandibular teeth and with the mandibular cortical plates. Materials: 116 cone beam computed tomography (CBCT) scans were examined and the shortest distance of IAC with the root apices of mandibular canines, premolars and molars, and with cortical plates was analyzed. The data were statistically analyzed using SPSS. Results: The shortest mean distance between IAC and lingual cortical plate (LCP) was found in the third molar area, and between IAC and buccal cortical plate (BCP) in the second premolar area. A high incidence of 60% direct communication (DC) was present in mandibular second molars; 38% in mandibular third molars; 13% in mandibular second premolars; 12% in mandibular first molars; and 1% in mandibular first premolars. Conclusion: Anteriorly, IAC was found to be significantly present in close approximation to the roots of mandibular canines. Posteriorly, IAC was found to be in significant proximity to the distal roots of mandibular second molars.
Clinical Features and Outcomes of Patients with Tetanus at Dr. Hasan Sadikin General Hospital Bandung 2015–2019

Background: Tetanus is a disease characterized by painful muscle spasms all over the body, which still becomes an important health issue worldwide, particularly in developing countries due to the high mortality rate. The clinical features also affect the mortality rate of adult tetanus patients. Tetanus severity score (TSS) is a prognostic scoring system developed in Vietnam that uses clinical features to predict the mortality rate in adult tetanus patients. The aim of this study was to describe the clinical features and outcomes of adult tetanus patients using TSS.Methods: A descriptive, cross-sectional study with a total sampling method was conducted between 2015 and 2019. A total of 71 medical records of adult generalized tetanus patients in the Department of Neurology Dr. Hasan Sadikin General Hospital Bandung were collected to analyze the clinical features and outcomes using TSS. Statistical analysis was performed using SPSS software ver. 25.0. Results: Among seventy-one tetanus patients, 62 (87.3%) were male, and the average age was 55.2±11.2 years. More than half of the patients (71%) were having grade III or worse and experienced dysautonomia complications (57.7%). The mortality rate was 38% and those who survived at discharge, 88.64% had TSS score <8, whereas 37.04% who died had TSS score ≥8.Conclusions: Tetanus in Bandung has a high mortality rate. Those who have died have high TSS scores, while the survivors have low TSS scores, suggesting that the TSS is a prospective scoring to predict the mortality rate in patients with tetanus in Indonesia.