Miracle-dz/UniFAR-FTUs huggingface dataset:
A novel long-acting local anesthetic – HTX-011 (ZYNRELEF™) for postoperative pain control

ABSTRACT Introduction Pain following most surgical procedures is expected. However, the treatment and management of postoperative surgical pain have remained challenging. The use of opioid therapy has become increasingly controversial given the limited therapeutic window of these drugs, the adverse side effects, and the potential for abuse. A multimodal approach to the treatment of postoperative pain has been shown to improve pain outcomes after surgery and improve patient satisfaction. Here, we examine a new formulation of bupivacaine and meloxicam extended-release solution HTX-011 (ZYNRELEF®) and its efficacy in postoperative pain control. Areas covered HTX-011 exists as an extended-release polymer that controls the release of the active ingredients over 72 hours. A systematic approach was taken to review PubMed (Medline) for prospective and retrospective studies related to the use of HTX-011 for the management of postoperative pain. Expert opinion HTX-011 represents a new tool to help modulate postoperative pain. Although multimodal analgesia has been effective in managing postoperative pain, direct surgical infiltration with local anesthetics has had limited efficacy due to their short duration of action. The HTX-011 formulation provides a long-acting local anesthetic at the surgical site, which provides a longer period of analgesia while maintaining a favorable safety profile.
Exploring the concept of non-violent resistance amongst healthcare workers

Background Non-violent resistance which has involved healthcare workers has been instrumental in securing a number of health-related gains and a force in opposing threats to health. Despite this, we know little about healthcare workers who have engaged in acts of non-violent resistance. Research aim Amongst a sample of healthcare workers who had engaged in acts of resistance this study sought to explore their understanding of non-violent resistance and how or whether they felt healthcare workers made a distinct contribution to such action. Research design Cross-sectional survey Participants and research context Healthcare workers (doctors, nurses, academics and others) from the UK and Europe who had engaged in acts of non-violent resistance. Ethical considerations Ethical approval for this study was granted by the University of Greenwich Human Research Ethics Committee (UREC/20.5.6.11). Findings/results Most participants spoke about the nature of non-violent resistance, its oppositional, didactic and symbolic functions and the role of violence or harm. While most people understood non-violent resistance as a public, oppositional and collective act, many identified more subtle everyday acts in the workplace that undermined policy or procedures they saw as harmful. When asked about distinctions in non-violent resistance carried out by healthcare workers, most participants referred to their standing in society, noting that healthcare works were a trusted and authoritative source. Some identified an ethical imperative to act while others identified the risks that came with such action, noting their accountability and responsibility they had to patients. About a quarter of participants felt that such action was no different to others carrying out non-violent resistance or dependent on the issue or nature of the action. Conclusions These findings speak to the complex and multifaceted nature of non-violent resistance. Additionally our findings suggest healthcare workers have a distinct role to play in leading and supporting non-violent actions.
Two-dimensional color-code quantum computation

We describe in detail how to perform universal fault-tolerant quantum computation on a two-dimensional color code, making use of only nearest neighbor interactions. Three defects (holes) in the code are used to represent logical qubits. Triple-defect logical qubits are deformed into isolated triangular sections of color code to enable transversal implementation of all single logical qubit Clifford group gates. Controlled-NOT (CNOT) is implemented between pairs of triple-defect logical qubits via braiding.
A curious source of extended X-ray emission in the outskirts of globular cluster GLIMPSE-C01

We report the discovery of an unusual source of extended X-ray emission CXOU J184846.3-013040 ('The Stem') located on the outskirts of the globular cluster GLIMPSE-C01. No point-like source falls within the extended emission which has an X-ray luminosity L X (0.3― 8 keV) ∼ 10 32 erg s ―1 and a physical size of ∼0.1 pc at the inferred distance to the cluster. These X-ray properties are consistent with the pulsar wind nebula of an unseen pulsar located within the 95 per cent confidence error contour of an unidentified Fermi γ-ray source OFGL J1848.6-0138. However, we cannot exclude an alternative interpretation that postulates X-ray emission associated with a bow shock produced from the interaction of the globular cluster and interstellar gas in the Galactic plane. Analysis of the X-ray data reveals that 'The Stem' is most significant in the 2-5 keV band, which suggests that the emission may be dominated by non-thermal bremsstrahlung from suprathermal electrons at the bow shock. If the bow shock interpretation is correct, these observations would provide compelling evidence that GLIMPSE-C01 is shedding its intracluster gas during a galactic passage. Such a direct detection of gas stripping would help clarify a crucial step in the evolutionary history of globular clusters. Intriguingly, the data may also accommodate a new type of X-ray source.
Lenalidomide-based triplet regimens in first relapsed multiple myeloma patients: real-world evidence from a propensity score matched analysis

Lenalidomide and dexamethasone (Rd)-based triplets, in particular carfilzomib-Rd (KRd) and daratumumab-Rd (DaraRd), represent a standard of care in lenalidomide-sensitive multiple myeloma (MM) patients in first relapse. Meta-analysis of randomized clinical trials (RCT), suggested better outcome with DaraRd. Trying to address this issue in clinical practice, we collected data of 430 consecutive MM patients addressed to Rd-based triplets in first relapse between January 2017 and March 2021. Overall, the most common used regimen was DaraRd, chosen in almost half of the cases (54.4%), followed by KRd (34.6%). Different triplets were used much less commonly. In an attempt to limit the imbalance of a retrospective analysis, we conducted a propensity score matching (PSM) comparison between DaraRd and KRd. After PSM, efficacy of DaraRd versus KRd was similar in terms of overall-response rate (ORR) (OR: 0.9, P=0.685) as well as of very good partial response (VGPR) or better (OR: 0.9, P=0.582). The median progression-free survival (PFS) was significantly longer for DaraRd (29.8 vs. 22.5 months; P=0.028). DaraRd was tolerated better, registering a lower rate of grade 3-4 non-hematological toxicity (OR: 0.4, P<0.001). With the limitations of any retrospective analysis, our real-life PSM comparison between DaraRd and KRd, in first-relapse MM patients, showed better tolerability and prolonged PFS of DaraRd, although with some gaps of performance, in particular of DaraRd, with respect to RCT. Carfilzomib-containing regimens, like KRd, still remain a valid second-line option in the emerging scenario of first-line daratumumab-based therapy.
CAN OVERTURNING MOTIONS IN PENUMBRAL FILAMENTS BE DETECTED?

Numerical simulations indicate that the filamentation of sunspot penumbrae and the associated systematic outflow (the Evershed effect) are due to convectively driven fluid motions constrained by the inclined magnetic field. We investigate whether these motions, in particular the upflows in the bright filaments and the downflows at their edges, can be reliably observed with existing instrumentation. We use a snapshot from a sunspot simulation to calculate two-dimensional maps of synthetic line profiles for the spectral lines Fe i 7090.4 Å and C i 5380.34 Å. The maps are spatially and spectrally degraded according to typical instrument properties. Line-of-sight velocities are determined from line bisector shifts. We find that the detectability of the convective flows is strongly affected by spatial smearing, particularly so for the downflows. Furthermore, the line-of-sight velocities are dominated by the Evershed flow unless the observation is made very near the disk center. These problems may have compromised recent attempts to detect overturning penumbral convection. Lines with a low formation height are best suited for detecting the convective flows.
Comparative Statics with Concave and Supermodular Functions

Certain problems in comparative statics, including (but not exclusively) certain problems in consumer theory, cannot be easily addressed by the methods of lattice programming. One reason for this is that there is no order on the choice space which orders choices in a way which conforms with the comparison desired, and which also orders constraint sets in the strong set order it induces. The objective of this paper is to show how lattice programming theory can be extended to deal with situations like these. We show that the interaction of concavity and supermodularity in objective or constraint functions yield a structure that is very useful for comparative statics.
THE COLLISIONAL EVOLUTION OF UNDIFFERENTIATED ASTEROIDS AND THE FORMATION OF CHONDRITIC METEOROIDS

Most meteorites are fragments from recent collisions experienced in the asteroid belt. In such a hypervelocity collision, the smaller collision partner is destroyed, whereas a crater on the asteroid is formed or it is entirely disrupted, too. The present size distribution of the asteroid belt suggests that an asteroid with a 100 km radius is encountered 1014 times during the lifetime of the solar system by objects larger than 10 cm in radius; the formed craters cover the surface of the asteroid about 100 times. We present a Monte Carlo code that takes into account the statistical bombardment of individual infinitesimally small surface elements, the subsequent compaction of the underlying material, and the formation of a crater and a regolith layer. For the entire asteroid, 10,000 individual surface elements are calculated. We compare the ejected material from the calculated craters with the shock stage of meteorites with low petrologic type and find that these most likely stem from smaller parent bodies that do not possess a significant regolith layer. For larger objects, which accrete a regolith layer, a prediction of the thickness depending on the largest visible crater can be made. Additionally, we compare the crater distribution of an object initially 100 km in radius with the shape model of the asteroid (21) Lutetia, assuming it to be initially formed spherical with a radius that is equal to its longest present ellipsoid length. Here we find the shapes of both objects to show resemblance to each other.
Soil Microbial Communities Associated with Three Arctic Plants in Different Local Environments in Ny–Ålesund, Svalbard

Understanding soil microbial community structure in the Arctic is essential for predicting the impact of climate change on interactions between organisms living in polar environments. The hypothesis of the present study was that soil microbial communities and soil chemical characteristics would vary depending on their associated plant species and local environments in Arctic mature soils. We analyzed soil bacterial communities and soil chemical characteristics from soil without vegetation (bare soil) and rhizosphere soil of three Arctic plants (Cassiope tetragona [L.] D. Don, Dryas octopetala L. and Silene acaulis [L.] Jacq.) in different local environments (coal-mined site and seashore-adjacent site). We did not observe any clear differences in microbial community structure in samples belonging to different plant rhizospheres; however, samples from different environmental sites had distinct microbial community structure. The samples from coal-mined site had a relatively higher abundance of Bacteroidetes and Firmicutes. On the other hand, Acidobacteria was more prevalent in seashore-adjacent samples. The relative abundance of Proteobacteria and Acidobacteria decreased toward higher soil pH, whereas that of Bacteroidetes and Firmicutes was positively correlated with soil pH. Our results suggest that soil bacterial community dissimilarity can be driven by spatial heterogeneity in deglaciated mature soil. Furthermore, these results indicate that soil microbial composition and relative abundance are more affected by soil pH, an abiotic factor, than plant species, a biotic factor.
POPULATION SYNTHESIS OF YOUNG ISOLATED NEUTRON STARS: THE EFFECT OF FALLBACK DISK ACCRETION AND MAGNETIC FIELD EVOLUTION

The spin evolution of isolated neutron stars (NSs) is dominated by their magnetic fields. The measured braking indices of young NSs show that the spin-down mechanism due to magnetic dipole radiation with constant magnetic fields is inadequate. Assuming that the NS magnetic field is buried by supernova fallback matter and re-emerges after accretion stops, we carry out a Monte Carlo simulation of the evolution of young NSs, and show that most of the pulsars have braking indices ranging from −1 to 3. The results are compatible with the observational data of NSs associated with supernova remnants. They also suggest that the initial spin periods of NSs might occupy a relatively wide range.
CHEMICAL PROCESSES IN PROTOPLANETARY DISKS

We have developed a high-resolution combined physical and chemical model of a protoplanetary disk surrounding a typical T Tauri star. Our aims were to use our model to calculate the chemical structure of disks on small scales (submilliarcsecond in the inner disk for objects at the distance of Taurus, ∼140 pc) to investigate the various chemical processes thought to be important in disks and to determine potential molecular tracers of each process. Our gas-phase network was extracted from the UMIST Database for Astrochemistry to which we added gas–grain interactions including freezeout and thermal and non-thermal desorption (cosmic-ray-induced desorption, photodesorption, and X-ray desorption), and a grain-surface network. We find that cosmic-ray-induced desorption has the least effect on our disk chemical structure while photodesorption has a significant effect, enhancing the abundances of most gas-phase molecules throughout the disk and affecting the abundances and distribution of HCN, CN, and CS, in particular. In the outer disk, we also see enhancements in the abundances of H2O and CO2. X-ray desorption is a potentially powerful mechanism in disks, acting to homogenize the fractional abundances of gas-phase species across the depth and increasing the column densities of most molecules, although there remain significant uncertainties in the rates adopted for this process. The addition of grain-surface chemistry enhances the fractional abundances of several small complex organic molecules including CH3OH, HCOOCH3, and CH3OCH3 to potentially observable values (i.e., a fractional abundance of ≳10−11).
Utilization of 18s ribosomal RNA LAMP for detecting Plasmodium falciparum in microscopy and rapid diagnostic test negative patients

In this study, Plasmodium falciparum was detected in patients that were declared negative for malaria microscopy and rapid diagnostic test kit (mRDT), using Plasmodium 18s rRNA loop-mediated isothermal amplification (LAMP) technique. The main aim of this study was to assess the usefulness of LAMP assay for detecting pre-clinical malaria, when microscopy and mRDT were less sensitive. DNA was obtained from 100 μL of whole blood using the boil and spin method. Subsequently, the Plasmodium 18s rRNA LAMP assay was performed to amplify the specific Plasmodium 18s rRNA gene. Microscopy and mRDT negative samples [697/2223 (31.2%)] were used for this study. Compared to frequencies obtained for the other demographic variables, most of the patients were < 6 years (37.7%), females (59.0%), peri-urban dwellers (39.0%) and patients that sought outpatient department services (39.3%). Overall, the prevalence of Plasmodium 18s rRNA was 17.5%. when stratified by study variables, Plasmodium 18s rRNA LAMP positivity was higher in patients over 30 years [58/122 (54.2%)], males [69/122 (56.5%)], rural dwellers [69/122 (56.5%)] and patients that sought OPD services [68/122 (55.7%)]. The risk of being infected with Plasmodium when routine tests were negative was higher in 15–30-year group (OR = 3.03, 95% CI: 1.6–5.8, p = 0.0007), patients > 30 years (OR = 15.2, 95% CI: 8.3–27.7, p<0.001), males (OR = 2.1, 95% CI: 1.4–3.2, p = 0.0002) and rural dwellers (OR = 2.2, 95% CI:1.4–3.6, p = 0.0009). However, risk was lower in post-natal children (OR = 0.3, 95% CI: 0.18–0.51, p<0.001). Majority (81.5%) of the infected patients presented with headache, herpes labialis, diarrhea and vomiting. We demonstrated the lack of sensitivities of microscopy and mRDT for one-time diagnosis of malaria. Therefore, it is essential to utilize a sensitive technique such as Plasmodium 18s rRNA LAMP to increase the detection rate of Plasmodium infection.
Removal of dyes (BG, MG, and SA) from aqueous solution using a novel adsorbent macrocyclic compound

The use of macrocyclic compounds to remove organic dyes is fascinating because they have a wide surface area range and can be used for different things. new (14E, 34E)-7-Hydroxy-7, 8, 22, 23, 24, 25, 26, 27-Octahydro-6H, 16H, 33H Tetrabenzo[f,k,u,z][1,5,13,20]Tetraoxacycloheptacosine-16,33-Dione (HOTTD) was obtained by a simple high-dilution method, and characterized by FTIR, 1H-NMR, FESEM, EDX, and XRD. It worked well in removing organic dyes from aqueous solutions. Contact time, pH, dosage, initial concentration and temperature were studied. The optimum conditions were achieved by using 20 mg/L dye concentration, 50 mg dose of adsorbent and pH 9.0 at room temperature. The adsorption process was remarkably fast and reached equilibrium within 10 min for both Brilliant Green and Malachite Green while 70 min for Safranin. The batch adsorption experiments followed a pseudo 2nd order and Langmuir model with maximum adsorption capacity 19.26 mg/g, 18.28 mg/g, and 14.35 mg/g for Brilliant Green, Malachite green and Safranin respectively. The process was endothermic and spontaneous in nature. Adsorbent regeneration test provides an excellent value 5 times.
Ulceration vs. Mitosis in Cutaneous Melanoma: Which Is Superior for Predicting Prognosis Across Clinical Stages?

Abstract Ulceration and high mitosis are considered among the major unfavorable prognostic factors in the survival of cutaneous melanoma patients. The aim of this study was to investigate the clinical significance of these parameters and to compare them to see which one is superior to predicting prognosis across all clinical stages of melanoma. A total of 1,074 melanomas were analyzed retrospectively. Tumor ulceration was found to be limited to the local stage for predicting survival, whereas, mitosis maintained its prognostic strength for predicting survival across all clinical stages. Furthermore, no survival differences were observed between ulceration and mitosis across clinical stages.
The Perceived Impact of the Namaste Care Family Program on Nursing Home Residents with Dementia, Staff, and Family Caregivers: A Qualitative Study

Objective(s): To examine the perspectives of staff, and family caregivers (i.e., family, friends, and volunteers) on the impact of the Namaste Care Family program on all involved. The Namaste Care Family program is a structured program for people with advanced dementia based on a palliative care approach in which family caregivers provide daily sessions together with staff with the aim to increase residents’ quality of life. Methods: In this descriptive qualitative study, we interviewed 12 family caregivers, and 31 staff members from 10 nursing homes. Data was analyzed thematically. Results: A perceived impact of the program was identified for the residents, staff, and family caregivers. For residents, this included well-being, more engagement, enhanced interactions, changes in energy level, and weight gain. The impact on family caregivers included a more positive view of people with dementia, changes in family visits, mixed feelings during sessions, and mixed changes in relations with all involved. For staff, this included diverse work experiences, shift to more person-centered care (more time and attention for residents, and more awareness), and developing relationships with residents and colleagues. Conclusions: The Namaste Care Family program was valued for its observed benefits and shift towards a person-centered care culture.
Exercise‐induced increase in M2 macrophages accelerates wound healing in young mice

Moderate‐intensity exercise performed during wound healing has been reported to decrease inflammatory cytokines and chemokines and accelerate wound healing. However, its effect on macrophage phenotype and the mechanism by which exercise accelerates wound healing remain unclear. The purpose of this study was to investigate the effect of exercise on macrophage phenotype during wound healing and to clarify the relationship between angiogenesis and wound healing. 12‐week‐old male C57BL/6J mice were divided into sedentary (n = 6) and exercise groups (n = 6). The exercise group performed moderate‐intensity treadmill running exercise (9.0 m/min, 60 min) for 10 days. Double immunofluorescence analysis was performed using F4/80+ inducible nitric oxide synthase (iNOS)+ for M1 macrophages, F4/80+ transforming growth factor‐beta (TGF‐β)1+ for M2 macrophages, and CD31+ alpha smooth muscle actin (α‐SMA)+ for angiogenesis. The exercise group showed significantly accelerated wound healing compared with the sedentary group. From early wound healing onward, exercise significantly inhibited M1 macrophage infiltration and increased M2 macrophage count. Exercise also significantly increased angiogenesis. Furthermore, the M2 macrophage phenotype was significantly correlated with angiogenesis in the exercise group, indicating that M2 macrophages and angiogenesis are related to accelerated wound healing. These findings suggest that moderate‐intensity exercise increases TGF‐β1 derived from M2 macrophages, which may be associated with enhanced angiogenesis and wound healing in young mice.
On the Doppler effect for photons in rotating systems

The analysis of the Doppler effect for photons in rotating systems, studied using the Mössbauer effect, confirms the general conclusions of a previous paper dedicated to experiments with photons emitted/absorbed by atoms/nuclei in inertial flight. The wave theory of light is so deeply rooted that it continues to be applied to describe phenomena in which the fundamental entities at work are discrete (photons). The fact that the wave theory of light can describe one aspect of these phenomena should not overshadow two issues: the corpuscular theory of light, first applied to the Doppler effect for photons by Schrödinger in 1922, is by far more complete since it describes all of the features of the studied phenomena; the wave theory can only be used when the number of photons at work is statistically significant. This disregarding of basic methodological criteria may appear to be a minor fault. However, the historical development of quantum physics shows that the predominance of the wave theory of radiation, beyond its natural application domain, has hampered the reorientation toward the photon description of the underlying phenomena.