Miracle-dz/UniFAR-FTUs huggingface dataset:
Unmet needs in histological transformation of follicular lymphoma: a clinical and biological review

Histological transformation, with its profound diagnostic and therapeutic implications, is considered to be one of the most unfavorable events in the natural history of follicular lymphoma (FL). No optimal treatment of transformed follicular lymphoma (tFL) has been identified because of its rarity and heterogeneous presentation, and the lack of data from randomized clinical trials. Consequently, its treatment has been based on that used in de novo diffuse large B-cell lymphomas. However, patients with tFL present a different behavior, with a worse clinical course and poor response to treatment, although their prognosis seems to have improved significantly since the introduction of rituximab into therapeutic schemes. There is no consensus definition of tFL, which prevents the genuine identification of transformation when a biopsy is unavailable. There are no biomarkers at diagnosis that accurately identify patients who will transform. A better knowledge of the pathways leading to transformation would clearly help to identify patients at risk of transformation, and to distinguish them from patients who will relapse with FL and from those who will remain disease-free. This would also facilitate the identification of new drug targets, the design of clinical trials and the treatment of transformation when it arises. In the present review we provide a comprehensive overview of the current open questions in the field of transformation of FL. Large-scale international collaborative studies are required to address these gaps in our knowledge.
Two Visual Systems and Their Eye Movements: a Fixation-Based Event-Related Experiment with Ultrafast fMRI Reconciles Competing Views

B.M. Velichkovsky, DSc, Professor, Corresponding Member of the Russian Academy of Sciences, Member of Academia Europaea (MAE), Chief Researcher1, 2; Senior Professor3; A.N. Korosteleva, Researcher1; S. Pannasch, Dr. rer. nat., Dr. habil. , Professor3; J.R. Helmert, Dr. rer. nat., Leading Researcher3; V.A. Orlov, Researcher1; M.G. Sharaev, PhD, Leading Researcher4; B.B. Velichkovsky, DSc, Professor, Department of Methodology of Psychology5; V.L. Ushakov, PhD, Associate Professor, Leading Researcher1; Senior Researcher6
The association of Big Five personality traits and religiosity on Internet addiction among Israeli-Palestinian Muslim college students in Israel

ABSTRACT Prior studies have demonstrated that personality traits and religiosity may be protective/risk factors for the development of Internet addiction; however, these associations have not been examined among the unique population of Israeli-Palestinian young adults. This study was the first to investigate the relationships between Internet addiction (Internet Addiction Test; IAT) with the Big Five personality traits (Big Five Personality Trait Short Questionnaire; BFPTSQ) and religiosity (Positions Regarding Religion Questionnaire) among a sample of Israeli-Palestinian Muslim college students (n = 350). IAT scores were positively associated with BFPTSQ openness (r = .33, p < .01), BFPTSQ extraversion (r = .30, p < .01), and BFPTSQ agreeableness (r = .36, p < .01), whereas IAT scores were negatively related to religiosity (r = −.46, p < .01), BFPTSQ conscientiousness (r = −.33, p < .01), and BFPTSQ emotional stability (r = −.36, p < .01). The present work may provide insight into risk factors for developing Internet addiction in a manner that may increase early identification and intervention efforts.
Low-temperature spin dynamics in the 
TmFeO3
 orthoferrite with a non-Kramers ion

S. A. Skorobogatov,1,2 S. E. Nikitin,3,4 K. A. Shaykhutdinov,1 A. D. Balaev,1 K. Yu. Terentjev,1 G. Ehlers,5 G. Sala,6 E. V. Pomjakushina,7 K. Conder,7 and A. Podlesnyak 6,* 1Kirensky Institute of Physics, Federal Research Center KSC SB RAS, Krasnoyarsk, 660036 Russia 2Department of Solid State Physics and Nanotechnology, Institute of Engineering Physics and Radioelectronics, Siberian Federal University, Krasnoyarsk 660041, Russia 3Max Planck Institute for Chemical Physics of Solids, D-01187 Dresden, Germany 4Institut für Festkörperund Materialphysik, Technische Universität Dresden, D-01069 Dresden, Germany 5Neutron Technologies Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831, USA 6Neutron Scattering Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831, USA 7Laboratory for Multiscale Materials Experiments, Paul Scherrer Institut, CH-5232 Villigen PSI, Switzerland
How Does a Radio Host’s Testimonial Influence Media Experiences? The Indirect Effect of Social Presence

This study examined how a radio host’s personal experiences (testimonials) influence listeners’ experiences, particularly focusing on the role of social presence. A Web-based experiment, using 113 undergrad students at a large public university in the United States, compared effects of a radio host’s sharing vs. not sharing testimonials during the radio program. The investigation found that social presence has significant indirect effects. Specifically, when the radio host shares testimonials, listeners experience a stronger feeling of social presence of the radio host, and it consequently fosters stronger levels of enjoyment, perceived credibility of the radio host, and information seeking intention.
Sınıf öğretmenlerinin Suriyeli öğrencilerin eğitimi ile ilgili yaşadıkları problemler

Bu arastirmanin amaci bulunan sinif ogretmenlerinin siniflarindaki Suriyeli ogrencilerin egitimi ile ilgili olarak karsilastiklari sorunlari ve cozum onerilerini tespit etmeye yoneliktir Arastirma, Suriyeli ogrencilerin yogun olarak bulundugu Mersin ilinin Toroslar ilcesinde bulunan 6 ilkokulda, 160 gonullu sinif ogretmenin katilimiyla gerceklestirilmistir. Ogretmenlere arastirmacilar tarafindan gelistirilen verilen veri toplama araci (anket) kisisel bilgi formu ve 22’si problemlerin tespitine 5’i cozum onerilerine yonelik 27 anket maddesi icermektedir. Arastirmadan elde edilen bulgular ogretmenlerin; Suriyeli ogrencilere yonelik olarak Turkce dil ve matematik becerilerinin yeterli olmadigi, yasi buyuk ogrencilerin uyum sorunu oldugu, kendi aralarinda siddet uyguladiklari, Turk ogrencilerle karsilikli siddet uyguladiklari, oyunlarinin siddet icerikli oldugu, arkadas secimlerini kendi aralarinda yaptiklari, okul kaynaklarinin ve veli katiliminin yeterli olmadigi ve rehberlik servisinin yeterli oldugu yonundeki goruslere katildigini gostermektedir. Ogretmenler; Suriyeli ogrencilerin ayri sinifta okumalari, velilerin ana-baba egitimine alinmasi, ogrencilerin kaynastirmadan sonra diger siniflarla birlestirilmesi ve yasi buyuk olanlarin ayri siniflarda egitim almalari konusundaki onerilere de cogunlukla katiliyorum duzeyinde gorus bildirmislerdir. Ankete verilen yanitlar uzerinde, SPSS programinda testler kullanilarak yas, cinsiyet, medeni durum, lisans egitimi, ogretmenlikte gecen kidem yili, okutulan sinif duzeyi ve hizmet ici egitim degiskenlerine gore fark analizi yapilmistir. Cinsiyete gore 2, lisans egitim durumuna gore 3, yasa gore 3, kideme gore 1, sinif duzeyine gore 5, hizmet ici egitime gore 5 maddede ogretmen gorusleri arasinda farklilik bulunmustur. Fark bulunan maddelere gore; kadin ogretmenlerin siddete karsi daha duyarli olduklari, Kidemli ogretmenler ile 4. Sinifi okutan ogretmenlerin uyum sorunlarina iliskin daha iyimser olduklari, Suriyeli cocuklarin egitimine yonelik hizmet ici egitim alanlarin siddet ve adaptasyon sorunlarina daha ilgili olduklari ifade edilebilir. Bu bulgular gelecege umutla bakmak icin sebep oldugu seklinde yorumlanmistir. Ote yandan, sorunlarin cozumu icin merkezi otoritenin inisiyatifinin beklendigi dusuncesiyle, yerel aktorlerin daha fazla aktif olmasinin yollarinin aranmasi gerektigi onerilmektedir.
Association between Ranibizumab Injections and Risk of Acute Myocardial Infarction in Age-related Macular Degeneration: A Case-crossover Study

Purpose This study aimed to evaluate the risk of acute myocardial infarction (AMI) associated with intravitreal ranibizumab in age-related macular degeneration (AMD). Methods This nationwide retrospective case-crossover study using data from the Korean National Health Insurance Service database included patients diagnosed with exudative AMD using the registration code for exudative AMD (V201) from 2009 to 2014. We identified all incident AMI cases among these exudative AMD cases from inpatient claims and defined the index date as the date of hospitalization. For each patient, we defined the case period as one to 60 days and four control periods as 121 to 180, 181 to 240, 241 to 300, and 301 to 361 days, respectively, before the index date. A prescription of ranibizumab was searched for during the case and control periods. We calculated the adjusted odds ratios and their 95% confidence intervals using a conditional logistic regression model. Results From a cohort of patients with exudative AMD (n = 41,860), a total of 181 AMI patients with exudative AMD were included. Among all the patients, 11.05% were treated during the 2 months preceding the index date as compared with 8.29% to 9.39% treated during control periods. The adjusted odds ratio of AMI associated with intravitreal ranibizumab during the preceding 2 months was 1.22 (95% confidence interval, 0.673–2.213; p = 0.5124). Analyses based on case periods of 15 days and 1 month yielded similar results. Conclusions Intravitreal ranibizumab injection does not appear to increase the risk of hospitalization for AMI within 60 days in exudative AMD patients.
Exercise training during pregnancy for overweight and obese women: A randomized controlled trial

Background The effectiveness of exercise training for preventing excessive gestational weight gain (GWG) and gestational diabetes mellitus (GDM) is still uncertain. As maternal obesity is associated with both GWG and GDM, there is a special need to assess whether prenatal exercise training programs provided to obese women reduce the risk of adverse pregnancy outcomes. Our primary aim was to assess whether regular supervised exercise training in pregnancy could reduce GWG in women with prepregnancy overweight/obesity. Secondary aims were to examine the effects of exercise in pregnancy on 30 outcomes including GDM incidence, blood pressure, blood measurements, skinfold thickness, and body composition. Methods and Findings This was a single-center study where we randomized (1:1) 91 pregnant women with a prepregnancy body mass index (BMI) 28 kg/m to exercise training (n = 46) or control (standard maternity care) (n = 45). Assessments were done at baseline (pregnancy week 12–18) and in late pregnancy (week 34–37), as well as at delivery. The exercise group was offered thrice weekly supervised sessions of 35 min of moderate intensity endurance exercise and 25 min of strength training. Seventeen women were lost to follow-up (eight in the exercise group and nine in the control group). Our primary endpoint was GWG from baseline testing to delivery. The principal analyses were done as intention-to-treat analyses, with supplementary per protocol analyses where we assessed outcomes in the women who adhered to the exercise program (n = 19) compared to the control group. Mean GWG from baseline to delivery was 10.5 kg in the exercise group and 9.2 kg in the control group, with a mean difference of 0.92 kg (95% CI −1.35, 3.18; p = 0.43). Among the 30 secondary outcomes in late pregnancy, an apparent reduction was recorded in the incidence of GDM (2009 WHO definition) in the exercise group (2 cases; 6.1%) compared to the control group (9 cases; PLOSMedicine | DOI:10.1371/journal.pmed. 1002079 July 26, 2016 1 / 18 a11111
Mid-Term Behaviour of Cemented Titanium Stems: A Seven to Eleven Year Clinical Radiographic and Retrieval Study

A controversy exists regarding the results of cemented Ti-alloy femoral stems. Although most authors reported unfavourable results, there is no clear evidence of the exact reason for the increased failure rate. We studied 35 arthroplasties in 30 patients with a mean age at the time of surgery of 49.7 years (range 27 to 67 years). In most of them (23 hips) the pre-operative diagnosis was hip dysplasia or dislocation. The femoral component used in this study was the Optifix stem. Survival analysis showed a cumulative rate of success at nine years of 90.4% (±15.3) with 25.5 femoral components remaining at risk. Three femoral components were retrieved during revision surgery: due to fatigue fracture, fracture of the femur and aseptic loosening respectively. Given that most publications refer to different designs of stems we presume that the problem could be focused on the design rather than the material or the method of fixation. Further information is necessary before Ti-alloy stems fixed with cement are withdrawn from use.
Charter value, risk-taking and systemic risk in banking before and after the global financial crisis of 2007-2008

ABSTRACT We investigate how bank charter value affects risk for a sample of OECD banks by using standalone and systemic risk measures before, during, and after the global financial crisis of 2007–2008. Prior to the crisis, bank charter value is positively associated with risk-taking and systemic risk for very large ‘too-big-too-fail’ banks and large U.S. and European banks but such a relationship is inverted during and after the crisis. A deeper investigation shows that such a behaviour before the crisis is mostly relevant for very large banks and large banks with high growth strategies. Banks’ business models also influence this relationship. We find that for banks following a focus strategy, higher charter value amplifies both standalone and systemic risk for large U.S. and European banks. Our findings have important policy implications and cast doubts on the relevance of the uniform more stringent capital requirements introduced by Basel III.
Antibiotic susceptibility of Pseudomonas aeruginosa isolated from different clinical sources

Pseudomonas aeruginosa (P. aeruginosa) is a Gram negative opportunistic pathogen which is responsible for many infections in humans. It is the causative agent of nosocomial pneumonia, urinary tract infection, surgical site infections and burn infection. Bacterial resistance to antibiotic is an increasing problems worldwide. Emergence of bacterial resistance to antimicrobials pose a challenge in treating pyogenic infection hence periodical monitoring of bacterial profile and their antibiotic susceptibility pattern is important. In current study, P. aeruginosa isolates obtained from different clinical sources were identified according to traditional biochemical tests. Antibiotic susceptibility testing was performed by the disc diffusion method. Importantly, present results show that 53% out of P. aeruginosa isolates exhibited multi drug resistance (MDR) pattern. P. aeruginosa isolates showed higher resistance to ciprofloxacin, gatifloxacin and meropenem and intermediate resistance to cefoperazone, cefepime, pipracillin, tobramycin, pipracillin-tazobactam, ceftazidime and azetreonem while Low bacterial resistance was noted against colistin only. The inappropriate use of antibiotics has led to the development of resistant bacteria which led to ineffective antibiotic therapy. Current study suggests applying of strict policies for antibiotic prescription and dispensing.
Improving the reproductive health of sub-Saharan Africas youth: a route to achieve the Millennium Development Goals.

As the fastest-growing region in the world sub-Saharan Africa is confronting many of the greatest global health and development challenges. With a population of more than 840 million and growing at the rate of 2.4 percent per year sub-Saharan Africa will double in size in just 30 years. Half the population in these countries is younger than 18. The future of sub-Saharan Africa rests to a great extent on the investments made in the education health and employment opportunities of its youth and on how successfully its youth transition to a healthy and productive adulthood. This chartbook provides information on education sexual experience and marriage HIV / AIDS maternal health and childbearing contraception violence and harmful practices and age structure population growth and the MDGs.
Becoming a Drug Dealer in Turkey

One of the major actors of ever-increasing drug crimes is the drug dealer. Turkey is a key country in the delivery of drugs due to its geographical location. In this research, in-depth interviews were conducted with 20 drug dealers who were formerly convicted in Turkey’s Diyarbakır province. Drug dealers are classified as drug smugglers, growers/manufacturers, shippers, wholesalers, and street vendors called “corner dealer. ” In this context, how drug dealers entered the drug trade, their reasons for entering it, and their previous criminal experiences were discussed. Important information has been gathered from the perspective of drug dealers on the process of being a criminal in the drug business. It is believed that the information provided will shed light on the problems of countries struggling with drugs.
Phosphate and nitrogen fertilization in the production of Barueiro (Dipteryx alata Vog.) seedlings

Abstract Barueiro (Dipteryx alata Vog.), a fruit tree native to the Brazilian cerrado, has aroused the interest of producers and consumers due to its almond highly appraised and valued by local markets. To obtain quality barueiro seedlings, balanced fertilization is required, with special attention to the supply of phosphorus and nitrogen, essential for seedling growth and establishment in the field. The aim of this study was to evaluate the growth of barueiro seedlings produced with different phosphate and nitrogen concentrations in Nova Xavantina – MT. The experiment was conducted at the seedling nursery of the Mato Grosso State University (UNEMAT), Campus of Nova Xavantina - MT, from December 2017 to April 2018. The experimental design was randomized blocks (DBC), in a 5 × 2 factorial scheme, corresponding to 5 phosphorus concentrations and 2 nitrogen concentrations, with 10 treatments, 4 blocks and 10 plants per plot, totalizing 400 seedlings. The applied concentrations were 0, 150, 300, 450 and 600 mg kg-1 P2O5 and 0 and 250 mg kg-1 N. The following variables were evaluated: plant height, plant stem diameter, number of leaves, number of leaflets, fresh and shoot and root dry mass and Dickson’s Quality Index. Significant interaction between phosphorus and nitrogen concentrations for all traits evaluated was observed, except for root dry mass. The greatest growth of barueiro seedlings was obtained when the highest phosphorus concentration (600 mg kg-1de P2O5) was used, associated to nitrogen fertilization of 250 mg kg-1. There was no isolated effect of phosphate fertilization on the growth of barueiro seedlings without nitrogen application.
PACKAGE OF BIRTHING BALL, PELVIC ROCKING, AND ENDORPHIN MASSAGE (BPE) DECREASE THE FIRST STEP LABOR PAIN

Background and Purpose : Labor pain is unpleasant and frightening experience for birth mother. In addition, labor pain cause exhaustion and childbirth trauma. Birthing ball, pelvic rocking, and endorphin (B.P.E) massage are emerging as non-pharmacology methods of pain management in labor. The aimed of this study was to investigate the effect of package of BPE on labour pain during the first stage of labor. Method: This study was quasi-experiment. Total numbers of samples were 23 mothers who were in the first stage of labor. Samples were selected by using quota sampling technique. Instrument of this study was numeric rating scale (NRS). Result: Data analysis by using paired sample t-test revealed that there were significantly different between before and after the intervention of BPE on labour pain during the first stage of labor in this study (p <0.01). Conclusion and recommendation : This study showed that BPE is effective as non-pharmacology methods on pain relieve of first stage of labor. Further study need to investigate other variables such as anxiety of birth mother. Key Words : labor pain, package of birth ball, pelvic rocking, and endorphin massage(BPE), labor process.
The Consequences of Cold Water Immersion: Impacts and Treatment

This paper documents a demonstration project conducted by the authors under the auspices of the Irish Naval service. It explores and describes in detail the consequences that cold water immersion can have on the human body. Further, this study investigates post immersion treatment and survival challenges and proposes appropriate casualty care regimes with specific focus on ‘post rescue collapse’ and ‘afterdrop. ’ Observations of individual differences in response are reported.
Right-sided Cardio-pulmonary Relationships in Endurance Athletes: Potential Long-term Consequences of Higher Pulmonary Pressure Generation during Exercise

Endurance-trained athletes (ETA) demonstrate physiologic cardiac adaptations, however few demonstrate indicators of reduced right-heart (RH) performance. This subset of ETA has not been characterized; they may be among those who generate higher pulmonary pressures (PP) during exercise. With RH catheterization during a graded-exercise protocol, PP during exercise were measured in 7 untrained controls and 16 ETA, with “high” and “low” pressure-generators (HPG, LPG) identified within our ETA cohort. Potential impacts of high-pressure states on longterm RH function were investigated with Echocardiography. A wide range in PP was produced in both cohorts, despite uniform RH enlargement in ETA. Compared to LPG, HPG athletes with peak-systolic PP over the median of 49mmHg demonstrated reduced resting RV systolic strain (p=0.04), slowed RV diastolic rate (p=0.03), and large left-atrial size (p<0.01). HPG demonstrated paradoxical increases in pulmonary vascular resistance in response to light exercise. Higher exercise-induced PP may influence long-term RH performance in ETA.
Serum C - Reactive Protein Level in Diabetic Foot Patients and Their Relation with Bacterial Isolates

Background: Foot infections are one of the major complications of diabetes mellitus and a significant risk factor for lower extremity amputation. C-reactive protein is an acute-phase reactant, rises dramatically in response to infection. Objective: To determine the microbial isolates of patients with diabetic foot infections and their relation with C-reactive protein level in their sera. Materials and Methods: A prospective study of 90 patients with diabetic foot infections admitted to different public and private hospitals in Erbil city center-Iraq between June 2011 and May 2012 was undertaken. Bacteriological specimens were obtained and processed using standard procedure. The patients serum had been tested for C-reactive protein by high sensitive Enzyme linked Immunosorbent Assay (ELISA). Results: A total of 130 pathogens were isolated from 90 diabetic foot patients 46 (51%) of the patients had polymicrobial infection, 37 (41%) had single organism and 7 (8%) had no growth. Gram positive (G+ve) bacteria 60(53%) were more commonly isolated than Gram negative (G-ve) bacteria 53(47%). Staphylococcus aureus and Escherichia coli were the most frequently among G+ve and G-ve isolates respectively. No significant difference was found between mean serum levels of C-reactive protein in patients infected with G+ve bacteria versus G-ve bacteria, although their concentration was more in the later. However, highly significant differences (P<0.01) were observed between both G+ve and G-ve bacteria versus no bacterial isolate in patients. Conclusion: C-reactive protein serum level was higher in patient with diabetic foot infected by G-ve bacteria, although G+ve bacteria represented a major bacterial isolates.