Miracle-dz/UniFAR-FTUs huggingface dataset:
The northernmost South American fossil record of Boa constrictor (Boidae, Boinae) from the Plio–Pleistocene of El Breal de Orocual (Venezuela)

Onary-Alves, S.Y. , Hsiou, A.S. & Rincón, A.D., July 2016. The northernmost South American fossil record of Boa constrictor (Boidae, Boinae) from the Plio–Pleistocene of El Breal de Orocual (Venezuela). Alcheringa 41, xxx–xxx. ISSN 0311-5518. Boa constrictor is an extant boid widely distributed through the neotropical region, from the north of Central America to central Argentina. The fossil record of the species includes examples from several localities across the Americas that extend beyond the current distribution of the species. Here we report the first Plio–Pleistocene fossils of Boa from Monagas state, Venezuela. The material comes from El Breal de Orocual (Maturín municipality), which is an inactive tar seep deposit emplaced within the Mesa Formation. The specimens consist of two isolated anterior trunk vertebrae, an articulated sequence of six mid-trunk vertebrae and two posterior trunk vertebrae. The vertebrae are attributed to B. constrictor based on the following features: robust and high vertebrae; thick zygosphene with a notched or concave anterior edge; presence of a paracotylar, subcentral and lateral foramina; marked parasagittal ridges; epizygapophyseal process evident on the dorsal surface of the postzygapophyseal articular facets and high blade-like neural spine. The presence of B. constrictor in northern of Venezuela indicates a palaeoenvironment probably like savanna crossed by rivers with riparian forests, and suggests the predominance of a mesothermal climate with a moderate rainfall. Silvio Y. Onary-Alves [silvioyuji@gmail.com], Programa de Pós-graduação em Biologia Comparada, Faculdade de Filosofia, Ciências e Letras, Universidade de São Paulo (USP), Av. Bandeirantes 3900, CEP 14040901, Ribeirão Preto, São Paulo, Brazil; Annie S. Hsiou [anniehsiou@ffclrp.usp. br], Laboratório de Paleontologia, Faculdade de Filosofia, Ciências e Letras, Departamento de Biologia, Universidade de São Paulo (USP), Av. Bandeirantes 3900, CEP 14040901, Ribeirão Preto, São Paulo, Brazil; Ascanio D. Rincón [paleosur1974@gmail.com], Laboratorio de Paleontología, Centro de Ecología, Instituto Venezolano de Investigaciones Científicas (IVIC), Carretera Panamericana Km 11, 1020-A Caracas, Venezuela.
Using Livelihood Profiles for Assessing Context in ICT4D Resarch: A Case Study of Zimbabwe's Highveld Prime Communal

The importance of context specific ICT4D innovation has been highlighted in Information Systems research by the short‐comings of a‐contextual innovation. This has often been accepted without due understanding of how to develop context specific interventions. There is therefore a need for a framework that elucidates ICT4D contextualisation and guides the development of context specific interventions. This should be useful to practitioners that are constantly advised to develop context specific artefacts without any clarity of how to do so. Using evidence from Zimbabwe this paper proposes the use of livelihood profiles for identifying the livelihood issues that matter in a particular locality and Sen's Capability Approach for assessing the opportunity freedoms to exploit the local livelihoods. This is presented as a systematic way of establishing the context under which ICT4D interventions will be deployed. The study uses focus groups under an interpretivist paradigm to investigate contextual issues in Zimbabwe Highveld Prime Communal livelihood zone. The study found a politically polarised contextual setting characterised by poor agricultural finance, ineffective crop and livestock markets, unrewarding labour markets against a good agricultural climate that is affected by cyclical droughts. As a result the study posits that ICT4D innovations for the zone must be designed to operate under these realities and limitations.
Pharmacological management of co-morbid obstructive sleep apnoea and insomnia

ABSTRACT Introduction Clinical presentation of both insomnia and obstructive sleep apnea (COMISA) is common. Approximately 30% of clinical cohorts with OSA have insomnia symptoms and vice versa. The underlying pathophysiology of COMISA is multifactorial. This poses a complex clinical challenge. Currently, there are no clinical guidelines or recommendations outside of continuous positive airway pressure (CPAP) therapy and cognitive behavioral therapy for insomnia (CBTi). Clinically translatable precision medicine approaches to characterize individual causes or endotypes may help optimize future pharmacological management of COMISA. Areas covered This review article provides an up-to-date account of COMISA and its consequences, the underlying pathophysiology of sleep apnea, insomnia and COMISA, current treatment approaches and limitations, pharmacotherapy targets and future priorities. Expert opinion There are multiple promising emerging therapies, but clinical trial data specifically in COMISA populations are lacking. This is a priority for future investigation to inform development of evidence-based guidelines. Pharmacotherapies, particularly for insomnia, do not target the underlying causes of the disorder thus, are indicated for short-term use only and should remain second line. Future multidisciplinary research should be directed toward the multifactorial nature of COMISA and the challenges of adapting COMISA treatment in clinical practice and overcoming the practical barriers that health-care providers and consumers encounter.
Multifrequency Analysis of Single Inductive Coil Measurements Across a Gel Phantom Simulation of Internal Bleeding in the Brain

The present study is part of an ongoing effort to develop a simple diagnostic technology for detecting internal bleeding in the brain, which can be used in lieu or in support of medical imaging and thereby reduce the cost of diagnostics in general, and in particular, would make diagnostics accessible to economically disadvantaged populations. The study deals with a single coil inductive device to be used for detecting cerebral hemorrhage. It presents a first‐order experimental study that examines the predictions of our recently published theoretical study. The experimental model employs a homogeneous cylindrical phantom in which internal head bleeding was simulated by way of a fluid inclusion. We measured the changes in amplitude and phase across the coil with a network vector analyzer as a function of frequency (100–1,000 MHz), volume of blood simulating fluid, and the site of the fluid injection. We have developed a new mathematical model to statistically analyze the complex data produced in this experiment. We determined that the resolution for the fluid volume increase following fluid injection is strongly dependent on frequency as well as the location of liquid accumulation. The experimental data obtained in this study supports the predictions of our previous theoretical study, and the statistical analysis shows that the simple single coil device is sensitive enough to detect changes due to fluid volume alteration of two milliliters. Bioelectromagnetics. 2020;41:21–33 © 2019 Bioelectromagnetics Society
Transcriptional profiling of human peripheral blood mononuclear cells in household contacts of pulmonary tuberculosis patients provides insights into mechanisms of Mycobacterium tuberculosis control and elimination

ABSTRACT Household contacts (HHCs) of patients with active tuberculosis (ATB) are at higher risk of Mycobacterium tuberculosis (M. tuberculosis) infection. However, the immune factors responsible for different defense responses in HHCs are unknown. Hence, we aimed to evaluate transcriptome signatures in human peripheral blood mononuclear cells (PBMCs) of HHCs to aid risk stratification. We recruited 112 HHCs of ATB patients and followed them for 6 years. Among the HHCs, only 2 developed ATB, while the remaining HHCs were classified into three groups: (1) HHC-1 group (n = 23): HHCs with consistently positive T-SPOT.TB test, negative chest radiograph, and no clinical symptoms or evidence of ATB during the 6-year follow-up period; (2) HHC-2 group (n = 15): HHCs with an initial positive T-SPOT result that later became negative without evidence of ATB; (3) HHC-3 group (n = 14): HHCs with a consistently negative T-SPOT.TB test and no clinical or radiological evidence of ATB. HHC-2 and HHC-3 were combined as HHC-23 group for analysis. RNA sequencing (RNA-seq) in PBMCs, with and without purified protein derivative (PPD) stimulation, identified significant differences in gene signatures between HHC-1 and HHC-23. Gene ontology analysis revealed functions related to bacterial pathogens, leukocyte chemotaxis, and inflammatory and cytokine responses. Modules associated with clinical features in the HHC-23 group were linked to the IL-17 signaling pathway, ferroptosis, complement and coagulation cascades, and the TNF signaling pathway. Validation using real-time PCR confirmed key genes like ATG-7, CXCL-3, and TNFRSF1B associated with infection outcomes in HHCs. Our research enhances understanding of disease mechanisms in HHCs. HHCs with persistent latent tuberculosis infection (HHC-1) showed significantly different gene expression compared to HHCs with no M. tuberculosis infection (HHC-23). These findings can help identify HHCs at risk of developing ATB and guide targeted public health interventions.
Gestalt neurons and emergent properties in visual perception: A novel concept for the transformation from local to global processing

Gestalten in visual perception are defined by emergent properties of the whole, which cannot be predicted from the sum of its parts; rather, they arise by virtue of inherent principles, the Laws of Seeing. This review attempts to assign neurophysiological correlates to select emergent properties in motion and contour perception and proposes parallels to the processing of local versus global attributes by classical versus contextual receptive fields. The aim is to identify Gestalt neurons in the visual system to account for the Laws of Seeing in causal terms and to explain “Why do things look as they do” (Koffka, 1935, p. 76).
Breakage fusion bridge cycles drive high oncogene copy number, but not intratumoral genetic heterogeneity or rapid cancer genome change

Oncogene amplification is a major driver of cancer pathogenesis. Breakage fusion bridge (BFB) cycles, like extrachromosomal DNA (ecDNA), can lead to high copy numbers of oncogenes, but their impact on intratumoral heterogeneity, treatment response, and patient survival are not well understood due to difficulty in detecting them by DNA sequencing. We describe a novel algorithm that detects and reconstructs BFB amplifications using optical genome maps (OGMs), called OM2BFB. OM2BFB showed high precision (>93%) and recall (92%) in detecting BFB amplifications in cancer cell lines, PDX models and primary tumors. OM-based comparisons demonstrated that short-read BFB detection using our AmpliconSuite (AS) toolkit also achieved high precision, albeit with reduced sensitivity. We detected 371 BFB events using whole genome sequences from 2,557 primary tumors and cancer lines. BFB amplifications were preferentially found in cervical, head and neck, lung, and esophageal cancers, but rarely in brain cancers. BFB amplified genes show lower variance of gene expression, with fewer options for regulatory rewiring relative to ecDNA amplified genes. BFB positive (BFB (+)) tumors showed reduced heterogeneity of amplicon structures, and delayed onset of resistance, relative to ecDNA(+) tumors. EcDNA and BFB amplifications represent contrasting mechanisms to increase the copy numbers of oncogene with markedly different characteristics that suggest different routes for intervention.
Stomatin-like protein 3 modulates the responses of Aδ, but not C fiber bone afferent neurons to noxious mechanical stimulation in an animal model of acute experimental bone pain

STOML3 is a membrane bound scaffolding protein that has been shown to facilitate the opening of mechanically sensitive ion channels and contribute to noxious mechanical sensation, allodynia and hyperalgesia. In this study, we aimed to determine the role of STOML3 in noxious mechanical sensitivity of bone afferent neurons and carrageenan-induced acute inflammation in the bone. An in vivo, electrophysiological bone-nerve preparation was used to make recordings of the activity and sensitivity of bone afferent neurons that innervate the tibial marrow cavity in anaesthetised rats, in response to noxious mechanical stimuli delivered to the marrow cavity, before and after injection of either the STOML3 oligomerisation inhibitor OB-1 or vehicle, in either naïve animals or animals with carrageenan-induced inflammation of the marrow cavity. A dynamic weight-bearing apparatus was used to measure weight bearing in response to inflammatory pain before and after injection of OB-1 or saline into the tibial marrow cavity in the presence of carrageenan-induced inflammation. Electrophysiological recordings revealed that Aδ, but not C bone afferent neurons have a reduced discharge frequency in response to mechanical stimulation, and that carrageenan-induced sensitisation of Aδ, but not C bone afferent neurons was attenuated by inhibition of STOML3 oligomerisation with OB-1. Animals treated with OB-1 spent a significantly greater amount of time on the limb injected with carrageenan than animals treated with saline. Our findings demonstrate that inhibition of STOML3 oligomerisation reduces inflammatory bone pain by reducing the sensitivity of Aδ bone afferent neurons to mechanical stimulation. Targeting STOML3 may be an effective approach to reduce pain from noxious pressure and/or painful inflammatory pathology in bone.
Effects of different wind stress climatologies on the North Atlantic circulation: Model results

Can we use ocean circulation models to test wind stress fields? Even in the cas perfect model, several issues need to be considered if we want to learn something comparing simulated volume transports with observations. Obviously, we have to ide circulation regimes where the oceanic transports are (predominantly) driven by the wind s so that changes in the winds have significant effects on the resulting circulation. In add we have to focus on those areas in the ocean where the transport is well-known observations. In this report, I shall discuss these issues for the case of the North Atlantic model being used is that developed by Bryan and Holland (1989) as a “Community Mod Effort” (CME) under the World Ocean Circulation Experiment (WOCE). The model spans Atlantic Ocean between 15 °S and 65°N. In recent years, a suite of model experiments has b conducted by the CME groups at NCAR and at IfM Kiel, differing in a number of mo factors, including horizontal resolution, frictional parameterization, wind and thermoha forcing. For model descriptions, list of experiments, and detailed accounts of the m circulation in different parts of the basin, the reader is referred to Bryan et al. (1994) Böning et al. (1994). Model results discussed in this report are all from a model version w grid resolution of 1/3 deg. in latitude, 2/5 deg. in longitude, and 30 levels in the vertical. Large-scale ocean circulation is forced by the momentum, heat and freshwater f at the surface. The thermohaline forcing in the Atlantic Ocean is associated with deep renewal in subarctic regions, driving an overturning motion with a northward flow of wa water in the upper 1000 or 1200 m, and southward flow of cold, North Atlantic Deep W between 1000 m and 4000–4500 m. The deep flow has a strong impact on the vorticity ba of the horizontal circulation in the subpolar North Atlantic. Both the CME-results (Bryan e 1994) and diagnostic modeling by Greatbatch et al. (1991) suggest that the structur strength of the subpolar gyre is governed by the thermohaline-driven flow and its intera with bottom topography, and to a much lesser degree by the wind stress. (This does no however, for the seasonal variability which, in good approximation, can be understood in of a linear response to the variation in the wind stress curl. Lack of data would presentl allow to use this behavior for a test of different wind stress fields in the subpolar N Atlantic.) A model evaluation in terms of a wind-driven transport has to be restricted to upper-layer circulation in the tropics and subtropics, south of the Gulf Stream recircul regime. The second requirement noted above, knowledge of volume transports observations in the ocean, readily lead to further restrictions. As recently discussed review of Schmitz and McCartney (1993), there is very little quantitative information
Nanoporous gold with microporous structure prepared by sodium dodecyl sulfate-mediated electrochemical dealloying

Nanoporous gold (NPG) is a promising catalytic material for the oxidation of CO and methanol applications. However, NPGs are prone to extensive macroscopic cracking that often decrease mechanic properties of NPGs and depresses their catalytic action. To produce crack-free NPG with an ultra-finer porosity in room temperature, the anionic surfactant sodium dodecyl sulfate (SDS) was added in electrochemical dealloying process. SDS has the effect of reducing the surface diffusion of gold which hinder the initial coarsening of ligaments and prevents interior silver atoms from being exposed and dissolved. As a result, the pore and ligment size are finer, but higher residual silver of NPG samples. NPG with pore size down to 2 nm and the ligament 4.0 nm was successfully fabricated with 13.32 mM SDS in perchloric acid solution. The surface diffusion coefficient of Au atoms was 1.6 × 10−24 m2·s−1, nearly 3 orders of magnitude smaller than that of Au atoms in the absence of SDS (2.8 × 10−21 m2·s−1). Nanoindentation results demonstrated that high residual silver content made NPG samples harder and stiffer，the specific surface areas of NPG with 6.66 mM SDS was 190 m2 g−1 by BET. This work provided very important clues on how to control the crack free ultrafine nanoporous structure of other materials.
Genomic analysis of Shigella isolates from Lebanon reveals marked genetic diversity and antimicrobial resistance

In this study, we characterized 54 clinical isolates of Shigella collected in North Lebanon between 2009 and 2017 through phenotypic and genomic analyses. The most prevalent serogroup was S. sonnei, accounting for 46.3 % (25/54) of the isolates, followed by S. flexneri (27.8 %, 15/54), S. boydii (18.5 %, 10/54) and S. dysenteriae (7.4 %, 4/54). Only three isolates were pan-susceptible, and 87 % (47/54) of the isolates had multidrug resistance phenotypes. Notably, 27.8 % (15/54) of the isolates were resistant to third-generation cephalosporins (3GCs) and 77.8 % (42/54) were resistant to nalidixic acid. 3GC resistance was mediated by the extended-spectrum beta-lactamase genes bla CTX-M-15 and bla CTX-M-3, which were present on various plasmids. Quinolone resistance was conferred by single point mutations in the gyrA DNA gyrase gene, leading to GyrA S83L, GyrA D87Y or GyrA S83A amino acid substitutions. This is the first study, to our knowledge, to provide genomic insights into the serotypes of Shigella circulating in Lebanon and the various antimicrobial resistance determinants carried by these strains.
Environmental Concern and the Intention to Use Eco-friendly Technologies: An Analysis of Battery Electric Vehicles in Macau.

A growing number of people are becoming aware of the environmental footprint that our actions have on the environment. Research indicates that a key factor leading to the adoption of an electric vehicle is consumers’ high environmental concern. Indeed, the environmental concern (EC) construct is commonly associated with the purchase of sustainable and eco-friendly products in literature. Our study challenges this assumption. We examined how the environmental factor influenced the behavioral intention of Macau residents to adopt battery-electric vehicle (BEV) technology. For this purpose, we conducted a study based on the UTAUT-2 framework and used structural equation modeling (SmartPLS) to analyze the data. As a result, the choice of vehicles did not depend on the consumers’ level of concern. It appeared that consumers strongly perceived the benefits of a cleaner environment, however, when it comes to technology, environmental benefits are nice to have, rather than the primary incentive to purchase BEVs. Researchers should consider the role of environmental concern as a background factor in technology acceptance models, rather than a direct predictor of behavior. It is also recommended that marketers correctly consider this element when developing their product communications strategies, to appeal to the desired segment of customers.
Australian health professionals' perspectives on discussing sexual activity and intimacy with people who have had a heart attack: a qualitative study.

BACKGROUND Sexual activity and intimacy contribute to wellbeing throughout adult life, including after a heart attack. Providing support and information about sexual activity and intimacy after a heart attack is recognised as part of a comprehensive approach to cardiac rehabilitation. Previous research shows that patients expect health professionals to initiate discussions about sexual activity and intimacy, but that this seldom occurs. METHODS Drawing on qualitative survey responses from a range of Australian health professionals working in cardiac care and rehabilitation, this research examined their perspectives on discussing sexual activity and intimacy with their patients, and patients' partners. Using a social constructionist approach, thematic analysis was used to identify themes expressed by participants. RESULTS Discussions about sexual activity and intimacy after heart attack were perceived as nebulous and taboo. The predominance of an illness - rather than wellness - framing of these discussions and a tendency for health professionals to make judgement calls contributed to discussions not occurring. Health professionals also identified a range of intrapersonal, interpersonal and structural obstacles to discussions, including embarrassment, fear of patients' embarrassment, a lack of role clarity, the absence of a clear protocol or training to guide practice, and a lack of time, privacy and patient resources. CONCLUSIONS Such discussions require normalisation, careful timing, sufficient time and adequate privacy. Staff training, a protocol and appropriate patient resources are needed to support health professionals to initiate discussions. Further research is required that investigates the impact of specific resources and training on health professionals' practice and patient outcomes.
The Role of Shared Auditors in Goodwill Impairment and Long-term M&A Performance

Using the mergers and acquisitions(M&A) of listed companies in China's A share market as a sample, this study examines the effect of shared auditors, defined as audit firms that provide audit services for both acquirer and target prior to the M&A transaction, on transaction outcomes. The results show that shared auditor deals are associated with significantly lower goodwill impairment and higher long-term M&A performance. Further mediation effect analysis suggests that goodwill impairment is a mediator between shared auditors and long-term M&A performance, that is, shared auditors improve the long-term M&A performance by reducing the risk of goodwill impairment. Overall, our evidence suggests that social network, such as shared auditors, plays an important role in the outcomes of M&A transactions.