Miracle-dz/UniFAR-FTUs huggingface dataset:
Validation of the inventory of Callous-Unemotional Traits among school-going adolescents in Malaysia

A key component in the study of antisocial behaviour among adolescents is the presence of callous-unemotional (CU) traits. Among the established tools available to measure CU traits is the Inventory of Callous-Unemotional traits (ICU). To date, there is no validated questionnaire to assess CU traits for the local population. Therefore, there is a need to validate the Malay version of the ICU (M-ICU) so that research can be conducted to explore CU traits among adolescents in Malaysia. The aim of the study is to validate the M-ICU. Two phases of cross-sectional study involving 409 (phase 1 –exploratory factor analysis (EFA), n = 180; phase 2—confirmatory factor analysis (CFA), n = 229) adolescents aged between 13 to 18 years old were conducted from July until October 2020 at six secondary schools in Kuantan district. Participants were selected via multistage random sampling. The ICU was initially translated into Malay language using forward-backward translation procedure by a group of bilingual researchers. Study participants completed the final version of the M-ICU questionnaire and socio-demographic questionnaire. Data was analysed using SPSS version 26 and MPlus software for factor structure validity by performing EFA and CFA. Initial EFA revealed three factors with two items deleted. A further EFA with two factors resulted in the deletion of unemotional factor items. Cronbach’s alpha for overall scale improved from 0.70 to 0.74. CFA supported a two-factor solution with 17 items compared to the original English version that has three factors with 24 items. The findings revealed acceptable fit indices (RMSEA = 0.057, CFI = 0.941, TLI = 0.932, WRMR = 0.968). The study revealed that a two-factor model with 17 items of the M-ICU has good psychometric properties. The scale is valid and reliable to measure CU traits among adolescents in Malaysia.
Epithelial Gab1 calibrates RIPK3-dependent necroptosis to prevent intestinal inflammation

As a hallmark of inflammatory bowel disease (IBD), elevated intestinal epithelial cell (IEC) death compromises the gut barrier, activating the inflammatory response and triggering more IEC death. However, the precise intracellular machinery that prevents IEC death and breaks this vicious feedback cycle remains largely unknown. Here, we report that Grb2-associated binder 1 (Gab1) expression is decreased in patients with IBD and inversely correlated with IBD severity. Gab1 deficiency in IECs accounted for the exacerbated colitis induced by dextran sodium sulfate owing to sensitizing IECs to receptor-interaction protein kinase 3–mediated (RIPK3-mediated) necroptosis, which irreversibly disrupted the homeostasis of the epithelial barrier and promoted intestinal inflammation. Mechanistically, Gab1 negatively regulated necroptosis signaling through inhibiting the formation of RIPK1/RIPK3 complex in response to TNF-α. Importantly, administration of RIPK3 inhibitor revealed a curative effect in epithelial Gab1-deficient mice. Further analysis indicated mice with Gab1 deletion were prone to inflammation-associated colorectal tumorigenesis. Collectively, our study defines a protective role for Gab1 in colitis and colitis-driven colorectal cancer by negatively regulating RIPK3-dependent necroptosis, which may serve as an important target to address necroptosis and intestinal inflammation–related disease.
Two antagonistic response regulators control Pseudomonas aeruginosa polarization during mechanotaxis

The opportunistic pathogen Pseudomonas aeruginosa adapts to solid surfaces to enhance virulence and infect its host. Type IV pili (T4P), long and thin filaments that power surface‐specific twitching motility, allow single cells to sense surfaces and control their direction of movement. T4P distribution is polarized to the sensing pole by the chemotaxis‐like Chp system via a local positive feedback loop. However, how the initial spatially resolved mechanical signal is translated into T4P polarity is incompletely understood. Here, we demonstrate that the two Chp response regulators PilG and PilH enable dynamic cell polarization by antagonistically regulating T4P extension. By precisely quantifying the localization of fluorescent protein fusions, we show that phosphorylation of PilG by the histidine kinase ChpA controls PilG polarization. Although PilH is not strictly required for twitching reversals, it becomes activated upon phosphorylation and breaks the local positive feedback mechanism established by PilG, allowing forward‐twitching cells to reverse. Chp thus uses a main output response regulator, PilG, to resolve mechanical signals in space and employs a second regulator, PilH, to break and respond when the signal changes. By identifying the molecular functions of two response regulators that dynamically control cell polarization, our work provides a rationale for the diversity of architectures often found in non‐canonical chemotaxis systems.
Predictive Factors to Guide Empiric Antimicrobial Therapy of Acute Hematogenous Osteomyelitis in Children

Background: Acute hematogenous osteomyelitis (AHO) is a serious infection in children. Pediatric Infectious Diseases Society guidelines recommend empiric methicillin-resistant Staphylococcus aureus (MRSA) therapy in regions where MRSA accounts for more than 10–20% of all staphylococcal osteomyelitis. We sought to examine factors present at the time of admission which may predict etiology and guide empiric treatment for pediatric AHO in a region with endemic MRSA. Methods: We reviewed admissions with International Classification of Diseases 9/10 codes for AHO from 2011 to 2020 in otherwise healthy children. Medical records were reviewed for clinical and laboratory parameters present on the day of admission. Logistic regression was used to determine clinical variables independently associated with (1) MRSA infection and (2) non-Staphylococcus aureus infection. Results: A total of 545 cases were included. An organism was identified in 77.1% of cases and S. aureus was the most common (66.2%); 18.9% of all AHO cases were MRSA. Organisms besides S. aureus were identified in 10.8% of cases. CRP >7 mg/dL, subperiosteal abscess, history of any prior skin or soft tissue infection (SSTI) and need for intensive care unit admission were independently associated with MRSA infection. Vancomycin was used as an empiric treatment in 57.6% of cases. If the above criteria were relied upon to predict MRSA AHO, empiric vancomycin use could have been reduced by 25%. Conclusions: Critical illness, CRP >7 mg/dL at the time of presentation, subperiosteal abscess and history of SSTI are suggestive of MRSA AHO, and could be considered when planning empiric therapy. Further work is needed to validate these findings before wider implementation.
Hypothalamic Oxytocin Neuron Activation Attenuates Intermittent Hypoxia-Induced Hypertension and Cardiac Dysfunction in an Animal Model of Sleep Apnea

Background: Obstructive sleep apnea is a prevalent and poorly treated cardiovascular disease that leads to hypertension and autonomic imbalance. Recent studies that restore cardiac parasympathetic tone using selective activation of hypothalamic oxytocin neurons have shown beneficial cardiovascular outcomes in animal models of cardiovascular disease. This study aimed to determine if chemogenetic activation of hypothalamic oxytocin neurons in animals with existing obstructive sleep apnea-induced hypertension would reverse or blunt the progression of autonomic and cardiovascular dysfunction. Methods: Two groups of rats were exposed to chronic intermittent hypoxia (CIH), a model of obstructive sleep apnea, for 4 weeks to induce hypertension. During an additional 4 weeks of exposure to CIH, 1 group was treated with selective activation of hypothalamic oxytocin neurons while the other group was untreated. Results: Hypertensive animals exposed to CIH and treated with daily hypothalamic oxytocin neuron activation had lower blood pressure, faster heart rate recovery times after exercise, and improved indices of cardiac function compared with untreated hypertensive animals. Microarray analysis suggested that, compared with treated animals, untreated animals had gene expression profiles associated with cellular stress response activation, hypoxia-inducible factor stabilization, and myocardial extracellular matrix remodeling and fibrosis. Conclusions: In animals already presenting with CIH-induced hypertension, chronic activation of hypothalamic oxytocin neurons blunted the progression of hypertension and conferred cardioprotection after an additional 4 weeks of CIH exposure. These results have significant clinical translation for the treatment of cardiovascular disease in patients with obstructive sleep apnea.
Patient and disease characteristics, treatment practices and oncologic outcomes among patients with colorectal cancer: a population-based analysis

Background: The incidence of colorectal cancer (CRC) is increasing among young adults. We sought to report on patient and disease characteristics, treatment practice patterns and outcomes in this population. Methods: We conducted a retrospective cohort study using administrative health data from the Alberta Cancer Registry (2004–2015), including demographic and tumour characteristics, and treatment received. Outcome measures included overall and cancer-specific deaths. We used Cox regression and Kaplan–Meier curves to assess for factors associated with survival. Results: We included 18 070 patients with CRC (n = 1583 [8.8%] < 50 yr, n = 16 487 [91.2 %] ≥ 50 yr). Younger patients were more likely to present with locally advanced disease (21.0% v. 18.0%, p < 0.0001), stage III (16.4 % v. 14.6%, p < 0.0001) or metastatic (16.7% v. 13.8%, p < 0.0001) involvement. Younger patients were more likely to receive surgery (87.2% v. 80.9%, p < 0.0001), chemotherapy (59.6% v. 34.1%, p < 0.0001) or radiation therapy (49.5% v. 37.2%, p < 0.001). At 5 years, overall and cancer-specific survival was better among younger patients than older patients (30.6% v. 51.5% overall deaths, 27.5% v. 38.4% cancer-specific deaths, p < 0.0001). Conclusion: Despite higher stage and higher grade disease, young patients with CRC had more favourable oncologic outcomes than stage-matched older patients, which may be related to younger patients receiving more aggressive treatment. Further investigation should focus on optimal treatment patterns for young patients with CRC.
Numerical modelling of nonlinear effects in laminar flow through a porous medium

This paper deals with the introduction of a nonlinear term into Darcy's equation to describe inertial effects in a porous medium. The method chosen is the numerical resolution of flow equations at a pore scale. The medium is modelled by cylinders of either equal or unequal diameters arranged in a regular pattern with a square or triangular base. For a given flow through this medium the pressure drop is evaluated numerically. The Navier-Stokes equations are discretized by the mixed finite-element method. The numerical solution is based on operator-splitting methods whose purpose is to separate the difficulties due to the nonlinear operator in the equation of motion and the necessity of taking into account the continuity equation. The associated Stokes problems are solved by a mixed formulation proposed by Glowinski & Pironneau. For Reynolds numbers lower than 1, the relationship between the global pressure gradient and the filtration velocity is linear as predicted by Darcy's law. For higher values of the Reynolds number the pressure drop is influenced by inertial effects which can be interpreted by the addition of a quadratic term in Darcy's law. On the one hand this study confirms the presence of a nonlinear term in the motion equation as experimentally predicted by several authors, and on the other hand analyses the fluid behaviour in simple media. In addition to the detailed numerical solutions, an estimation of the hydrodynamical constants in the Forchheimer equation is given in terms of porosity and the geometrical characteristics of the models studied.
Mixing Layer Formation near the Tropopause Due to Gravity Wave–Critical Level Interactions in a Cloud-Resolving Model

Abstract A plausible mechanism for the formation of mixing layers in the lower stratosphere above regions of tropical convection is demonstrated numerically using high-resolution, two-dimensional (2D), anelastic, nonlinear, cloud-resolving simulations. One noteworthy point is that the mixing layer simulated in this study is free of anvil clouds and well above the cloud anvil top located in the upper troposphere. Hence, the present mechanism is complementary to the well-known process by which overshooting cloud turrets causes mixing within stratospheric anvil clouds. The paper is organized as a case study verifying the proposed mechanism using atmospheric soundings obtained during the Central Equatorial Pacific Experiment (CEPEX), when several such mixing layers, devoid of anvil clouds, had been observed. The basic dynamical ingredient of the present mechanism is (quasi stationary) gravity wave–critical level interactions, occurring in association with a reversal of stratospheric westerlies to easterlies b.
Morphological examination and scanning electron microscopy of the barn owl's (Tyto alba) tongue

The beak structure changes according to the feeding patterns of birds. Further, the morphological and histological structures of their tongues vary. Therefore, the current study aimed to perform macroanatomical and histological examinations and scanning electron microscopy of the barn owl's (Tylo alba) tongue. Two dead barn owls were brought to the anatomy laboratory and were used as study material. The tongue of the barn owl was long, triangular‐shaped with a bifurcated tip. There were no papillae in the anterior 1/3 of the tongue, and the lingual papillae were shaped toward the back. The radix linguae were surrounded by a single row of conical papillae. Irregular thread‐like papillae were found on both sides of the tongue. The salivary gland ducts were on the lateral margin of the corpus linguae and the dorsal surface of the radix linguae. The lingual glands were in the lamina propria near the stratified squamous epithelium layer of the tongue. The dorsal surface of the tongue comprised non‐keratinized stratified squamous epithelium, and the ventral surface and caudal part of the tongue had keratinized stratified squamous epithelium. Hyaline cartilages were detected in the connective tissue immediately below the non‐keratinized stratified squamous epithelium on the dorsal surface of the root of the tongue. The study results can contribute to the current knowledge on the anatomical structure of birds. Further, they can be useful in managing the barn owl when used as companion animals and in research activity.
Hepatitis B virus reactivation associated with Janus kinase (JAK) inhibitors: a retrospective study of pharmacovigilance databases and review of the literature

ABSTRACT Background Recently, there have been clinical reports of hepatitis B virus reactivation (HBVr) related with Janus kinase (JAK) inhibitors. However, there were no studies to investigate the association between HBVr and different JAK inhibitors. Research design and methods This study was a retrospective review utilizing the FAERS pharmacovigilance database and a systematic literature search for all cases of HBVr reported with JAK inhibitors. Disproportionality analysis and Bayesian analysis were used in data detection to screen the suspected HBVr after the administration of different JAK inhibitors, based on the FDA Adverse Event Reporting System (FAERS) pharmacovigilance database from Q4 2011 to Q1 2022. Results There were a total number of 2097 (0.02%) reports of HBVr in FAERS, of which 41 (1.96%) were associated with JAK inhibitors. Baricitinib appeared to have the strongest signal among four JAK inhibitors, based on the highest reporting odds ratio (ROR = 4.45, 95% confidence interval [CI] 1.67–11.89). Ruxolitinib also showed signals, whereas no signals were detected among Tofacitinib and Upadacitinib. Conclusion While there may be an association between JAK inhibitors and HBVr, it appears to be a numerically uncommon occurrence. Further studies are needed to optimize the safety profiles of JAK inhibitors.
Magnetic field draping against the dayside magnetopause

Interplanetary magnetic fields observed upstream of Earth's magnetosphere at ISEE 3 form input for a gas dynamic model of magnetic field draping in the dayside magnetosheath. Model results near the magnetopause are compared with appropriately lagged observations at ISEE 1. In 16 of 24 cases the angle between the transverse component of the model and observed fields is less than 20°. The agreement is surprisingly good in view of the uncertainty introduced by the large distances between ISEE 1 and ISEE 3. The results indicate that magnetohydrodynamic and energy transfer processes at the magnetopause do not cause large distortions of the magnetosheath magnetic field. In addition, a comparison between observed and model field magnitudes indicates that immediately outside the magnetopause the observed field behaves like the model field at a distance of ∼0.5 RE from the magnetopause, outside the region where magnetohydrodynamic effects make the gas dynamic model inapplicable. Patterns of model magnetic field orientation at the magnetopause are presented for practical application.
Singularities in water waves and the Rayleigh–Taylor problem

We describe, by means of asymptotic methods and direct numerical simulation, the structure of singularities developing at the interface between two perfect, inviscid and irrotational fluids of different densities ρ1 and ρ2 and under the action of gravity. When the lighter fluid is on top of the heavier fluid, one encounters the water-wave problem for fluids of different densities. In the limit when the density of the lighter fluid is zero, one encounters the classical water-wave problem. Analogously, when the heavier fluid is on top of the lighter fluid, one encounters the Rayleigh–Taylor problem for fluids of different densities, with this being the case when one of the densities is zero for the classical Rayleigh–Taylor problem. We will show that both water-wave and Rayleigh–Taylor problems develop singularities of the Moore-type (singularities in the curvature) when both fluid densities are non-zero. For the classical water-wave problem, we propose and provide evidence of the development of a singularity in the form of a logarithmic spiral, and for the classical Rayleigh–Taylor problem no singularities were found. The regularizing effects of surface tension are also discussed, and estimates of the size and wavelength of the capillary waves, bubbles or blobs that are produced are provided.
The lightning discharge

A survey of the data available indicates that lightning flashes in all thunderstorms have similar characteristics as regards the times involved and the number of strokes in a flash, and it is shown that Norinder's divergent values are due to misinter-pretation of his data. It is suggested that while the charge neutralized in a lightning flash is probably about 50% greater than has hitherto been believed, the cloud potential is only a few per cent of the accepted value, and the energy of a flash about 250 kWh, as compared with Wilson's value of about 2800 kWh. A theory is advanced bearing on the mechanism of the leader and return strokes, which enables the shape of the lightning current wave to be calculated; in addition, a form is derived for the whole current wave in a multiple flash. A synthesis made from the results of many investigations leads to a picture of the mechanism of the return stroke and to the calculation of the various field changes produced, which agree well with those observed both in shape and in amplitude. New light is thrown on the analysis of the electrostatic field change caused by a stroke. The importance of space charge is emphasized in several connections, including the neutralization of cloud charge thereby, the frequency of ? air discharges? and the peculiarity of flashes to the Empire State Building, the currents to which have been re-analysed. The effect of direct strokes to transmission lines is investigated, and it is shown that successive strokes which do not cause flashover are unlikely. The polarity of flashes to earth is shown to differ in tropical and temperate regions, and it is concluded that the polarity of strokes to phase wires cannot be deduced from that of strokes to towers. Suggestions are made as to further investigations.
Mesenchymal Stem Cells Versus Placebo for Perianal Fistulizing Crohn’s Disease: A Systemic Review and Meta-Analysis

Background Mesenchymal stem cells (MSCs)-based therapy for perianal fistulizing Crohn’s disease (pfCD) has been extensively studies in the past decade. Its efficacy and safety had been preliminarily confirmed in some phase 2 or phase 3 clinical trials. This meta-analysis is performed to evaluate the efficacy and safety of MSCs-based therapy for pfCD. Methods Electronic databases (Pubmed, Cochrane Library, Embase) were searched for studies that reported the efficacy and safety of MSCs. And RevMan were used to assess the efficacy and safety. Results After screening, 5 randomized controlled trials (RCTs) were included in this meta-analysis. RevMan 5.4 for meta-analysis showed that: [Efficacy] Patients had definite remission after MSCs treatment, with an odds ratio (OR) of 2.06 (P < .0001, 95%CI 1.46, 2.89) vs controls. [Safety] The incidence of the most frequently reported TEAEs (treatment-emergent adverse events, TEAEs), perianal abscess and proctalgia, did not significantly increase due to the use of MSCs, with an OR of 1.07 in perianal abscess (P = .87, 95%CI 0.67, 1.72) vs controls, and an OR of 1.10 in proctalgia (P = .47, 95%CI 0.63, 1.92) vs controls. Conclusions MSCs seem to be an effective and safe therapy for pfCD. MSCs based therapy has the potential to be used in combination with traditional therapies.
Argument Structure in Usage-Based Construction Grammar: Experimental and corpus-based perspectives

The argument structure of verbs, defined as the part of grammar that deals with how participants in verbal events are expressed in clauses, is a classical topic in linguistics that has received considerable attention in the literature. This book investigates argument structure in English from a usage-based perspective, taking the view that the cognitive representation of grammar is shaped by language use, and that crucial aspects of grammatical organization are tied to the frequency with which words and syntactic constructions are used. On the basis of several case studies combining quantitative corpus studies and psycholinguistic experiments, it is shown how a usage-based approach sheds new light on a number of issues in argument realization and offers frequency-based explanations for its organizing principles at three levels of generality: verbs, constructions, and argument structure alternations.