Miracle-dz/UniFAR-FTUs huggingface dataset:
Poly(glutamic acid) Modified Pencil Graphite Electrode for Voltammetric Determination of Bisphenol A

: Bisphenol A (BPA), which is an endocrine-disrupting substance, is often utilized as beverage and food packing material, and it may accumulate in nutrition and water sources, which is why it is important to monitor. In this study, for the determination of bisphenol A, electro-polymerization of glutamic acid (GA) was performed on a pencil graphite electrode (PGE). The performance of the sensor (PGA/PGE) for determining bisphenol A was examined utilizing the cyclic voltammetric (CV) and differential pulse voltammetric (DPV) methods. Electrochemical characterization process of the PGA/PGE was carried out by the electrochemical impedance spectroscopy (EIS) and CV methods. The morphological property of the PGA/PGE was investigated by scanning electron microscopy (SEM). The presence of functional groups in the PGA/PGE composition was characterized by Fourier transform infrared spectroscopy (FTIR). The electrochemical behavior of BPA was observed with the bare PGE and the PGA/PGE. Based on the findings, the response of BPA was considerably raised with PGA/PGE. With the optimized parameters and based on the findings from DPV, the BPA oxidation current was linear in a concentration interval of 1.0 to 100 μM (R=0.9992), and the detection limit was found to be 0.37 μM. Detection of BPA in the plastic bottled drinking water sample using PGA/PGE was performed successfully, and the recoveries were in the range of 89.3 to 104.7%. This strategy can provide several prospects in electrochemically determining BPA in practical applications.
Association between APOC3 polymorphisms and non-alcoholic fatty liver disease risk: a meta-analysis

Background and Aim The apolipoprotein C3 (APOC3) polymorphism has been reported to predispose to non-alcoholic fatty liver disease (NAFLD). However, the results remain inconclusive. This meta-analysis aimed to provide insights into the association between APOC3 polymorphisms and NAFLD risk. Methods Studies with terms “NALFD” and “APOC3” were retrieved from PubMed, Web of Science, CNKI and Wanfang databases up to August 1, 2019. Pooled odds ratio (OR) and 95% confidence interval (95% CI) for the association of APOC3 polymorphisms and NAFLD risk were calculated using fixed and random-effects models. Results A total of twelve studies from eleven articles were included. Of them, eight studies (1750 cases and 2181 controls) reported the strong association of variant rs2854116 with NAFLD and six studies (1523 cases and 1568 controls) found the association of rs2854117 polymorphism with NAFLD. Overall, a statistically significant association between rs2854116 polymorphism of APOC3 gene and NAFLD risk was found only under dominant model. However, association of rs2854117 polymorphism with NAFLD risk was not detected under all four genetic models. In sub-group analysis of NAFLD subjects based on country, no association among them in China was detected. Besides, four studies analyze the association between the two polymorphisms and clinical characteristics in all subjects or NAFLD patients, and we also failed detect any association between the wild carriers and variant carriers. Conclusion The meta-analyses suggests that the rs2854116 polymorphism but not rs2854117 polymorphism in APOC3 gene might be a risk factor for NAFLD among Asians. That is, individuals with CT+CC genotype have higher risk of developing NAFLD. However, studies with sufficient sample size are needed for the further validation.
Knowledge of Avulsion of Permanent Teeth Emergency Management Among Undergraduate in Brazilian Health Care Students

Objective: To assess the knowledge of undergraduate health care students, about avulsion of permanent teeth. Material and Methods: It is a cross-sectional study. The sample consisted of Brazilian undergraduate students of the nursing, medicine, and dentistry degree programs. A structured questionnaire developed by the researchers, containing 18 objective questions about avulsion of permanent teeth was used as the data collection. Data analysis included Pearson's Chi-square and Fisher's Exact. Results: A total of 82.7% dental students, 22.9% nursing students, and 23% medical students had previously received some information about dental trauma. Students in the second half of the dentistry program had a higher percentage of correct answers in all questions (p<0.05). Being in the first or second half of the nursing program had no relation to the percentage of correct answers by students for any questions (p>0.05). Students in the first half of the medical program had a higher percentage of correct answers for six of these questions (p<0.05). Dentistry students had the highest percentage of correct answers in all the questions (p<0.001). Conclusion: Although students from the dentistry degree program report having information on avulsion of permanent teeth, their practical experience was considered low. Upon comparing students from the dentistry, nursing, and medical degree programs regarding their learning about avulsion of permanent teeth, dentistry students had greater knowledge on the subject. Descriptive analysis was done using absolute and relative frequency for categorical variables and mean and standard deviation values for numerical variables. The Kolmogorov– Smirnov test demonstrated non-normal distribution. To compare the frequency of correct answers between the first and second half of each degree program and between the dentistry, nursing, and medical studies programs, Pearson's Chi-square and Fisher's Exact tests were used. The level of significance was set at 5% (p<0.05).
Salinomycin suppresses TGF-β1-induced EMT by down-regulating MMP-2 and MMP-9 via the AMPK/SIRT1 pathway in non-small cell lung cancer

Salinomycin (Sal) is a recently identified anti-tumor drug for treating several types of solid tumor; however, its effects on the migratory and invasive properties of non-small cell lung cancer (NSCLC) remain unclear. This study investigated the inhibitory effect underlying mechanisms of Salon transforming growth factor-β1 (TGF-β1)-induced epithelial-to-mesenchymal transition (EMT) and cell migration. Sal solidly blocked cell migration and invasion enhancement by TGF-β1-induced EMT, through recovering E-cadherin loss and suppressing mesenchymal markers induction, as well as TGF-β1-mediated AMPK/SIRT signaling activity upregulation. The pharmacologic inhibition or knockdown of AMPK or SIRT1 can act synergistically with Sal to inhibit TGF-β1-induced MMP-2 and MMP-9. In contrast, AMPK or SIRT1 upregulation can protect against TGF-β1-induced MMP-2 and MMP-9 inhibition by Sal. Next we demonstrated that the MMP-2 and MMP-9 knockdown can act synergistically with Sal to inhibit TGF-β1-induced EMT. Moreover, treatment of PMA of MMP activator increased TGF-β1-induced MMP-2 and MMP-9, even with Sal. Our results demonstrate that Sal suppresses TGF-β1-induced EMT by downregulating MMP-2 and MMP-9 through the AMPK/SIRT pathway, thereby inhibiting lung cancer cell migration and invasion.
Toward Reproducible and Extensible Research: from Values to Action

The National Academies report, "Reproducibility and Replicability in Science," outlines values and broad goals for reproducible and replicable scientific research, emphasizing the importance of its availability and transparency. Confronted with these goals, we examine what it means for research material to be transparent, available, and reproducible. As early-career researchers, we advocate for the focus to be placed on reusable and extensible research, which is naturally achieved when research material is reproducible, transparent, and open. When we understand the inner workings of a study, have access to its inputs and outputs, and are able to achieve the same results ourselves, we can more easily reuse, extend, and generalize prior efforts. To achieve the outlined reproducibility goals, one needs actionable steps that facilitate implementation and help mark progress in practice. We discuss concrete guidelines and checklists as tools for actionable reproducibility. We emphasize how a set of hierarchical recommendations that give an order of importance to the various aspects of reproducibility, transparency, and openness would help researchers facing limited resources prioritize accordingly. Finally, we discuss how training, new roles focusing on reproducibility, and supportive work environments would be beneficial.
Global Bibliometric Analysis of the ‘Mining & Mineral Processing’ Subject Category From the Web of Science (1997–2012)

The main objective of this study is to analyze the evolution of the research in the category ‘Mining & Mineral Processing’. First, we have revised journals that are in this subject category in the database Science Citation Index-Expanded (SCI-E) of the Web of Science (WoS). Second, we have analyzed publications for journals between 1997 and 2012, with an analysis from the perspective of both quantity and quality. To do this, we have analyzed various bibliometric indicators for different countries and research centers such as the number of documents (article and review), showing per document, productivity, the average number of citations, authors, research centers, national and international collaboration including their networks, the weighted and relative impact factor, as well as the h-index. Furthermore, we have analyzed the international dissemination of research of countries through journals and the relationship with the impact factor to detect the published journals of each country. We have also shown that English is the most common language of publication, and the United States is the most productive country, although it has a relatively low impact factor due to the dispersion of its publications in low or medium impact journals. We can also see that University of Science and Technology of Beijing and the Russian Academy of Sciences have been the most productive institutions during the period under study, along with the large increase of the Atomic Energy and Alternative Energies Commission of France (CEA).
The crystal structure of nambulite (Li,Na)Mn4Si5O14(OH)

IOSTENMACrmR, T. J., SZALDA, D. J. & MARZILLI, L. G. (1975b). lnorg. Chem. In the press. MANYAK, A. R. , Mu~'nv, C. B. & MARTELL, A. E. (1955). Arch. Biochem. Biophys. 59, 373-382. MARZlLLI, L. G. & KISTENMACHER, T. J. (1974). 168th National Meeting of the American Chemical Society, Atlantic City, New Jersey, Abstract A3. MARZILLI, L. G. , KISTENMACHER, Z. J. & CHANG, C. H. (1973). J. Amer. Chem. Soc. 95, 7507-7508. MARZmLI, L. G. , KISTENMACHER, T. J., DARCY, P. E. , SZALDA, D. J. & BEER, M. (1974). J. Amer. Chem. Soc. 96, 4686-4688. Pn, PY, M. E. & AmvmD, F. R. (1968). NRC Crystallographic Programs, National Research Council, Ottawa, Canada. SAITO, K. , TERASHIMA, R. , SAKAKI, T. & TOMITA, K. (1974) Biochem. Biophys. Res. Commun. 61, 83-86. STEWART, J. M. (1967). X-RAY 67. Technical Report 67-58, Computer Science Center, Univ. of Maryland, College Park, Maryland. STEWART, R. F. , DAVmSON, E. R. & SIMPSON, W. T. (1965). J. Chem. Phys. 42, 3175-3187. STRANDBERG, B. , LINDQVIST, I. & ROSENSTEIN, R. (1961). Z. Kristallogr. 116, 266-289. SUNDARALINGAM, M. t~ CARRABINE, J. A. (1971). J. Mol. Biol. 61,287-310. SZALDA, D. J., MARZILLI, L. G. & KISTENMACHER, T. J. (1975a). Biochem. Biophys. Res. Commun. 63, 601-605. SZALDA, D. J., MARZILLI, L. G. & K~Sa-ENMACHER, T. J. (1975b). Inorg. Chem. In the press. WIGGINS, J. W. &BEER, M. (1972). Anal. Chem. 44, 77A-81A. WILSON, A. J. C. (1942). Nature, Lond. 150, 152. ZIMMER, C. , LUCK, G. & TRIESEL, H. (1974). Biopolymers, 13, 425--453.
Prevalence of Self-Reported Symptoms of Sexually Transmitted Infection among Establishment-Based Female Sex Workers in Ethiopia

Introduction In spite of the fact that female sex workers being regarded as core transmitters of sexually transmitted infections to the general population, previous studies undertaken around STIs in Ethiopia fail to consider this segment of the population. Hence, the present study investigated the prevalence of self-reported symptoms of STIs and the risk factors among FSWs in Adama Town, Ethiopia. Method A cross-sectional study was conducted from May 01, 2017, to April 30, 2017, in Adama Town. Three hundred ninety female sex workers were selected from 120 licensed drinking establishments by using simple random sampling technique. The interviewer-administered structured tool was used to collect data. Data were entered using EPI data version 3.1 and exported to SPSS version 20 for analysis. Bivariate and multivariable logistic regression analyses were used to identify factors associated with the outcome variable. Result Among the requested 423 female sex workers, 390 willingly responded to the interviewer-administered structured questionnaires making a response rate of 92.2%. One hundred thirty-nine (35.6%, 95% CI (33.8%–37.4%) of the female sex workers reported one or more STI symptoms. Several risk factors were identified including inconsistent condom use with a nonpaying client (AOR = 5.43, 95% CI: 2.73, 10.80), alcohol use before sex (AOR = 2.41, 95% CI: 1.35, 4.30), longer duration of sex work (AOR = 2.27, 95% CI: 1.26, 4.08), and having poor knowledge of STIs (AOR = 2.44, 95% CI: 1.31, 4.54). Conclusion Self-reported symptom of STI among female sex workers in Adama Town is relatively high when compared with previous studies. Hence, health education programs should address the issue of inconsistent condom use with nonpaying clients, alcohol consumption before sex, and knowledge of STIs, with a particular emphasis on those female sex workers who stayed longer in the business.
Desenvolvimento de Heliconia psittacorum e Gladiolus hortulanus irrigados com águas residuárias tratadas

This research aims to evaluate the impact of irrigation with treated domestic wastewater (TDW) on the growth of ornamental plant species. The experiment was installed in the town of Simoes Filhos (BA), in a randomized block design with sub-divided plots, cultivated with Heliconia psittacorum and Gladiolus hortulanus using surface drip irrigation with TDW and river water. The evaluated parameters were: stem length, button number (parakeet flower and gladiola), and plant height, number of tillers, plant diameter and nutriment content (only parakeet flower). Among the factors which affect the growth of the plant, soil porosity and soil salinity (electrical conductivity - EC) were measured for 0 to 0.3 m soil depth. No significant difference was observed for the plant morphology. Changes in soil micro and macroporosity, EC and sodicity after 180 days of irrigation were also insignificant. However, a beginning of soil salinization was found after one year of experimentation, which signifies a possible change in the monitored parameters in the medium to long term.
The Pattern and Causes of Neonatal Mortality in a Tertiary Hospital in the Southwest of Nigeria

Background: The neonatal mortality rate remains high in developing countries despite the significant reduction in under-five mortality globally. Therefore, periodic evaluations on the causes of mortality are an aspect of health status, which could be performed to improve the neonatal mortality rate. Objectives: The present study aimed to determine the pattern and causes of neonatal mortality in the Federal Medical Center in Owo, Ondo State, Southwest Nigeria. Methods: This retrospective study was conducted using the hospital records of the neonates admitted over a five-year period from 1st of January 2015 to 31st of December 2019. Results: In total, 2,065 neonates were admitted, including 208 cases of neonatal deaths. Mortality occurred in 127 males (61.1%) and 81 females (38.9%), with the male-to-female ratio of 1.6:1. Among the recorded deaths, 114 cases (54.8%) occurred within the first 24 hours of admission, while 94 neonates (45.2%) died after 24 hours of admission. In addition, the mortality rate was higher among outborn neonates (n = 120; 57.7%) compared to inborn neonates (n = 88; 42.3%). The major causes of neonatal deaths included birth asphyxia (46.6%), prematurity (23.1%), and sepsis (17.8%). The overall mortality rate over the five-year period was 10.1%, which is equivalent to 19 deaths per 1,000 live births. Conclusions: According to the results, preventable diseases such as birth asphyxia, prematurity, and sepsis remain the major causes of neonatal mortality, of which neonatal deaths occur mostly within 24 hours of admission.
Pelatihan Pembuatan Herbarium Sebagai Pengayaan Media Pembelajaran Ipa-Biologi Bagi Guru Smp Mgmp Ipa Di Kecamatan Way Tenong Kabupaten Lampung Barat

Sebagian besar guru SMP IPA di Kecamatan Way Tenong bukan dari latar belakang Pendidikan Biologi, namun tetap harus dapat mengajarkan materi tentang Biologi. Dalam mengajar Biologi mereka sering menemui kendala, yaitu kesulitan mendapatkan bahan yang sesuai. Untuk menanggulangi hal tersebut dapat digunakan objek awetan antara lain herbarium. Pelaksanaan Pelatihan dilakukan dengan pendekatan pemberian teori dan praktek langsung membuat herbarium. Pelatihan diikuti oleh 31 orang guru SMP MGMP IPA Lampung Barat. Sebelum pelatihan dilaksanakan , pengetahuan peserta tentang pembuatan herbarium sebesar 44,5%. Setelah pelatihan pengetahuan peserta meningkat menjadi 93,2%. Dengan demikian terjadi peningkatan pengetahuan sebesar 48,7%. Hasil Pelatihan, berupa herbarium dapat digunakan sebagai media pembelajaran bidang IPA khususnya Biologi.
The development of jarak towo cassava as a high economical raw material in sustainability-based food processing industry

Cassava was regarded as inferior food; however, with the advancement of processing technology, cassava products have a potential for higher economic value today. One type of cassava that is used as a raw material for food processing industries, restaurants, cafes, or hotels is jarak towo cassava. However, the supply of this agricultural product is insecure due to the long growing period before harvesting and limited land suitability for cultivating this plant. This article aims at investigating sustainability-based the development of jarak towo cassava as the raw material in food processing industry. A total of 60 farmers cultivating jarak towo cassava took part in this study as the respondents. Snowball sampling was applied to take samples from three sub-districts in Karanganyar Regency. In-depth information was also obtained from key informants, including policy-makers and experts in cassava development. The data were analyzed using the Multi-Dimensional Scaling (MDS) method. The results of the analysis show the less sustainable multidimensional status of jarak towo cassava development. The prioritized strategies for developing jarak towo cassava are determined based on the driving and leverage variables. Farmers’ active participation in farmer groups and the roles of agricultural extension in jarak towo cassava farming become the driving variables stimulating the other nine key factors, which belong to leverage variables. Those leverage variables include land suitability, the use of pesticides, the setting of planting frequency, the use of seedlings, planting diversification, the use of fertilizers, the availability of water during the planting period, impacts on erosion, and cooperation.
Domination of Regional Wealth as a Determining Factor of Financial Statement Disclosure

AbstractUsing Stewardship theory, this study examines the factors that influence the level of mandatory disclosure within financial statements of provincial governments in Indonesia, including size of government, regional wealth, number of Regional Working Units (SKPD), administrative age of government and audit findings. By applying the purposive sampling method, this study uses a sample of financial statements from 27 provinces in Indonesia during 2016 to 2018, therefore the total sample is 81 financial statements. The findings reveal that there is a moderate level of compliance with key mandatory disclosures (61,33%). In addition, the regression analysis shows that from the five potential predictor variables, regional wealth is the only predictor that is significantly positive towards the level of mandatory disclosure within financial statements of Indonesian provincial governments. Given overall non-compliance rate of over 38% there is a clear need for the Indonesian government especially the Supreme Audit Board (BPK) to better enforce provincial government's compliance combined with important financial reforms and regulations.
Direct Observation of the Depth of Active Groundwater Circulation in an Alpine Watershed

The depth of active groundwater circulation is a fundamental control on stream flows and chemistry in mountain watersheds, yet it remains challenging to characterize and is rarely well constrained. We collected hydraulic conductivity, hydraulic head, temperature, chemical, noble gas, and 3H/3He groundwater age data from discrete levels in two boreholes 46 and 81 m deep in an alpine watershed, in combination with chemical and age data from shallow groundwater discharge, to discern groundwater flow rates at different depths and directly observe active and inactive groundwater. Vertical head gradients are steep (average of 0.4) and thermal profiles are consistent with typical linear conductive continental geotherms. Groundwater deeper than ∼20 m is distinct from shallow groundwater and creek water in its chemistry, noble gas signature, and age (dominantly >65 years compared to <9 years). Together these results suggest low vertical groundwater flow velocities and a relatively shallow active circulation depth of ∼20 m. This hypothesis is tested with a simple 2‐D numerical fluid flow and heat transport model representing a hillslope transect through the two boreholes. The modeling indicates that the subhorizontally bedded sedimentary rocks underlying the basin are highly anisotropic with low vertical hydraulic conductivity, and at most ∼10% of bedrock recharge (equivalent to <2% of stream baseflow) flows below a depth of 20 m. The study demonstrates the considerable value of discrete‐depth hydrogeologic, chemical, and age data for determining active circulation depth, and illustrates an approach for maximizing the utility of individual boreholes drilled for mountain bedrock aquifer characterization.