Miracle-dz/UniFAR-FTUs huggingface dataset:
CMAR_A_247554 4585..4593

1Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan; 2Department of Pharmacy, Keio University Hospital, Tokyo, Japan; 3Division of Endocrinology, Metabolism and Nephrology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan; 4Department of Neurology, Keio University School of Medicine, Tokyo, Japan; 5Department of Urology, Keio University School of Medicine, Tokyo, Japan; 6Department of Dermatology, Keio University School of Medicine, Tokyo, Japan; 7Division of Pulmonary Medicine, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan; 8Keio Cancer Center, Keio University School of Medicine, Tokyo, Japan Purpose: Immune checkpoint inhibitors (ICIs) have been approved for various types of
Transcriptional Regulation of the Human Toll-Like Receptor 2 Gene in Monocytes and Macrophages1

This report investigates the molecular basis for tissue-restricted and regulated expression of the pattern recognition receptor Toll-like receptor (TLR)2 in human monocytes and macrophages. To define the proximal promoter, the full 5′-sequence and transcriptional start sites of TLR2 mRNA were determined. The human TLR2 gene was found to consist of two 5′ noncoding exons followed by a third coding exon. Alternative splicing of exon II was detected primarily in human blood monocytes. The proximal promoter, exon I, and part of intron I were found to be located in a CpG island. Although CpG methylation of the proximal human TLR2 promoter in cell lines correlated with TLR2 repression, the promoter was unmethylated in primary cells, indicating that CpG methylation does not contribute to the cell-type specific expression of human TLR2 in normal tissues. The promoter sequence contains putative binding sites for several transcription factors, including Sp1 and Ets family members. Reporter gene analysis revealed a minimal promoter of 220 bp that was found to be regulated by Sp1, Sp3, and possibly PU.1. Interestingly, no sequence homology was detected between human and murine TLR2 promoter regions. In contrast to murine TLR2, expression of human TLR2 in monocytes/macrophages is not induced by the proinflammatory stimuli LPS or macrophage-activating lipopeptide-2, and reporter activity of the promoter was not enhanced by stimuli-induced NF-κB activation in THP-1 or MonoMac-6 cells. Our findings provide an initial definition of the human TLR2 promoter and reveal profound differences in the regulation of an important pattern recognition molecule in humans and mice.
ha l00 12 60 00 , v er si on 1-2 3 Ja n 20 07 SYMMETRIES OF CONTACT METRIC MANIFOLDS

We study the Lie algebra of infinitesimal isometries on compact Sasakian and K–contact manifolds. On a Sasakian manifold which is not a space form or 3– Sasakian, every Killing vector field is an infinitesimal automorphism of the Sasakian structure. For a manifold with K–contact structure, we prove that there exists a Killing vector field of constant length which is not an infinitesimal automorphism of the structure if and only if the manifold is obtained from the Konishi bundle of a compact pseudo–Riemannian quaternion–Kähler manifold after changing the sign of the metric on a maximal negative distribution. We also prove that non–regular Sasakian manifolds are not homogeneous and construct examples with cohomogeneity one. Using these results we obtain in the last section the classification of all homogeneous Sasakian manifolds. 2000 Mathematics Subject Classification. Primary 53C25, 53C26
Oral Health Knowledge and Practıces of Chıldren in a Primary School in Turkey

th grades mounted to 234 students in the study school; the participation proportion was 97.0% (n=227). The data were gathered via a self-administered questionnaire filled in the classrooms in 2007. The questionnaire used was similar to that used in 2004 study of oral health in Turkey. Questionnaire form included 61 questions.
Least Strenuous Path: A New Bio Factor for Strategic Policies on Adaptations for Coping with Climate Change in Africa with Special Reference to Highly Suffered Zambia

Agriculture is activity involved in producing food world over but is getting limited in its productivity functions [1,2]. There had been global concern on carrying out assessment on loss in such productive capacities of ecosystems comprising locations and natures. The climate change is becoming insurmountable deterrent for agriculture for which world over concerns have developed [3-10]. Loss in social economic status had also been studied [3]. Endeavors have been searching for losses and adaptations of measures to cope up with climate change devastations. Studies move around assessing abiotic factors on different adverse impacts and infrastructural degradations. Extension scientists concentrated their research on choice based human factors, which can never cover entire domain of problems and technological improvement measures did not come in picture. The countries where agriculture is irrigated, depression in yields due to drought or floods during the rainy season can get compensated by enhancement in yield under milder climatic situation viz winter Crimson Publishers Wings to the Research Research Article
Nutrition and Aging Energy Restriction Reduces Bone Density and Biomechanical Properties in Aged Female Rats

Bone mineral density (BMD) is highly correlated with body weight, and weight loss is associated with reduced BMD. Whether such losses of BMD increase skeletal fragility is unclear. We examined the effect of 9 wk of energy restriction (ER) on bone density, mineral and matrix protein composition and biomechanical properties in mature (20 wk old, n 5 12) and aged (48 wk old, n 5 16) female rats. Energy-restricted rats were fed 40% less energy than controls that consumed food ad libitum. Bone content of mineral (ash and calcium content) and matrix proteins (hydroxyproline, pyridinium crosslinks and proteoglycans), serum hormones, site-specific bone density and biomechanical properties (peak load, peak torque, shear stiffness and bending stiffness) were measured at the conclusion of the study. In both age groups, ER reduced body weight by 15 6 10% (P , 0.001) and dramatically decreased femoral bone density by 32–35% (P , 0.01) compared with controls. Energy restriction resulted in a small reduction in tibia and humerus density, as well as biomechanical properties in the aged but not mature rats (P , 0.05). Reduced serum levels of insulin and estradiol due to ER in aged rats (P , 0.05) may play a role in altering bone quality. These data show that although weight loss due to ER is detrimental to some bone parameters in mature rats, only aged rats show consistent reductions in bone density and biomechanical properties. J. Nutr. 131: 2382–2387, 2001.
INJURIES RELATED TO COMPETITIVE AND NONCOMPETITIVE SPORTS IN ELDERLY MEN

Objective: To verify the sociodemographic profile and the frequency of musculoskeletal injuries in elderly people who practice competitive and noncompetitive sports activities in the city of Pelotas, RS. Methods: Descriptive study, including 29 male subjects, aged 65 years or older, who practiced sports modalities in a competitive and noncompetitive way, in the city of Pelotas, in 2015. Data collection was performed through the application of a questionnaire with questions addressing economic, sociodemographic, nutritional and behavioral issues, and injuries sustained in sports activities. Statistical analysis was performed by calculating measures of central tendency for continuous variables and proportions for categorical variables. Results: The current practice of competitive sports was described by 58.6% (n=17) of the subjects, and the most practiced sports were 7-a-side football (53.0%, n=9), tennis (23.5%, n=4) and swimming (23.5%, n=4). Noncompetitive sports were practiced by 44.8% (n=13), and tennis was the most popular sport played (92.3%, n=12). The frequency of injuries among individuals practicing competitive and noncompetitive sports was, respectively, 35.3% (n=6), and 38.5% (n=5). The most frequent injuries were epicondylitis (50.0%, n=3) and meniscus injuries (60.0%, n=3), and the most affected body regions were knee (27.3%, n=3), elbow (27.3%, n=3), and shoulder (18.2%, n=2). The injuries occurred during the sports activities, and the dominant side was the one affected in 63.6% (n=7). Conclusion: This study verified that the occurrence of injuries in elderly individuals who practice sports is relevant, even among those who practice them noncompetitively, with epicondylitis as the most frequent among them, whereas meniscus injuries are the most frequent among those who practice competitive sports. incluso en aquellos que no lo hacen por competición siendo la más común la epicondilitis. Las lesiones del menisco es la más común entre los practicantes de competición. Descriptores: Anciano; Deportes; Traumatismos
JPET #109272 1 A Potent Immunomodulatory Compound, VGX-1027, Prevents Spontaneous and Accelerated Forms of Autoimmune Diabetes in NOD Mice and Inhibits the Immunoinflammatory Diabetes Induced by Multiple Low Doses of Streptozotocin in CBA/H Mice

VGX-1027 ((S,R)-3-phenyl -4,5-dihydro-5-isoxasole acetic acid) is an isoxazole compound which exhibits various immunomodulatory properties. The capacity of VGX1027 to prevent IL-1β+IFN-γ-induced pancreatic islets death in vitro, prompted us to evaluate its effects on the development of autoimmune diabetes in preclinical models of human type 1 diabetes mellitus (T1D). Administration of VGX-1027 to NOD mice with spontaneous or accelerated forms of diabetes induced either by injection of Cyclophosphamide or by transfer of spleen cells from acutely diabetic syngeneic donors, markedly reduced the cumulative incidence of diabetes and insulitis. In addition, VGX1027 given either i.p. or per os to CBA/H mice made diabetic with multiple low doses of streptozotocin (MLD-STZ), successfully counteracted the development of destructive insulitis and hyperglycemia. The animals receiving VGX-1027 exhibited reduced production of proinflammatory mediators TNF-α, IL-1β, MIF and iNOS-mediated NO generation in both pancreatic islets and peripheral compartments. These results indicate that VGX-1027 probably exerts its antidiabetogenic effects by limiting cytokinemediated immunoinflammatory events leading to inflammation and destruction of pancreatic islets. VGX-1027 seems worthy of being considered as a candidate drug in the development of new therapeutic strategies for the prevention and early treatment of T1D. This article has not been copyedited and formatted. The final version may differ from this version. JPET Fast Forward. Published on December 5, 2006 as DOI: 10.1124/jpet.106. 109272 at A PE T Jornals on A uust 5, 2017 jpet.asjournals. org D ow nladed from
Validating Object Oriented Design Quality using Software Metrics

-Software Metrics have been traditionally used as primary source for determining the Software Product Quality. In this paper, we propose an approach for determining the design quality of an Object Oriented Software using software metrics. To validate the proposed methodology, we have chosen three Open Source software projects of good, average and bad design quality which is known priori. For each of these projects, we extracted a set of chosen software metrics that play a definite role in software design quality. After applying various required normalizations on these metric values, we determined the design quality for the above stated three projects. We found that software design quality determined in this way was in confirmation with the priori known end product quality. The outcomes of the experimental study provide a strong base for the effectiveness of our proposed approach for metric based design quality measurement of object-oriented software.
Automatic Generation Approach of Short Titles

Automatic titling of text documents is an essential task for several applications (automatic heading of e-mails, summarization, and so forth). In this article, we present a technique that suggests titles showing coherence with both the text and the Web, as well as with their dynamic context. The approach evaluation indicates that automatically generated titles are informative and/or catchy.
Heterology Expression of the Arabidopsis C-Repeat/Dehydration Response Element Binding Factor 1 Gene Confers Elevated Tolerance to Chilling and Oxidative Stresses in Transgenic Tomato

In an attempt to improve stress tolerance of tomato ( Lycopersicon esculentum ) plants, an expression vector containing an Arabidopsis C-repeat/dehydration responsive element binding factor 1 ( CBF1 ) cDNA driven by a cauliflower mosaic virus 35S promoter was transferred into tomato plants. Transgenic expression of CBF1 was proved by northern- and western-blot analyses. The degree of chilling tolerance of transgenic T 1 and T 2 plants was found to be significantly greater than that of wild-type tomato plants as measured by survival rate, chlorophyll fluorescence value, and radical elongation. The transgenic tomato plants exhibited patterns of growth retardation; however, they resumed normal growth after GA 3 (gibberellic acid) treatment. More importantly, GA 3 -treated transgenic plants still exhibited a greater degree of chilling tolerance compared with wild-type plants. Subtractive hybridization was performed to isolate the responsive genes of heterologous Arabidopsis CBF1 in transgenic tomato plants. CATALASE1 ( CAT1 ) was obtained and showed activation in transgenic tomato plants. The CAT1 gene and catalase activity were also highly induced in the transgenic tomato plants. The level of H 2 O 2 in the transgenic plants was lower than that in the wild-type plants under either normal or cold conditions. The transgenic plants also exhibited considerable tolerance against oxidative damage induced by methyl viologen. Results from the current study suggest that heterologous CBF1 expression in transgenic tomato plants may induce several oxidative-stress responsive genes to protect from chilling stress. Tolerance
Teachers' knowledge and issues in the implementation of school-based assessment: A case of schools in Terengganu / Raja Nurul Huda Raja Zahri

In tandem with educational best practices the world over, School-based assessments (SBAs) were introduced in Malaysia in 2012 for secondary one students. This study investigated quantitatively and qualitatively matters such as the teachers' knowledge of SBAs and the issues faced when implementing SBAs, whereas the factors contributing to the problems of SBA implementation was investigated only qualitatively. A sample of 60 English teachers in the district of Dungun, Terengganu, who were involved in SBAs from the beginning were chosen as respondents. Out of this, 20 teachers were interviewed to obtain qualitative findings. It was found that teachers had satisfactory knowledge of planning an SBA-tailored lesson. They also showed satisfactory knowledge of developing SBAs but appeared to have difficulty in the psychometrics of test analysis. As for issues faced by teachers, they were not indifferent to SBA implementation but team work and collaboration among SBA teachers needs to be improved. Teachers faced problems in SBA implementation but overall had a positive attitude towards SBA. Teachers voiced concerns over the lack of adequate staff numbers, lack of uniformity and a possible element of biasness in grading. Teachers also faced time constraints, lack of effective materials and methodologies and poor ICT facilities in schools. They also feared cheating by students in SBAs. The findings have important implication in introducing best practices into SBA such as consistency and uniformity of grading and impartiality of teachers. Future researchers should investigate the success of SBA implementation after a few years.
FORAGING EFFICIENCY ALONG WITH FORAGING METHODS UTILIZED BY LITTLE EGRET (EGRETTA GARZETTA) IN DIFFERENT HABITATS OF JAMMU REGION

The foraging efficiency and foraging methods of Little Egret Egretta garzetta were studied during March 2013 to February 2016 by direct observation of individuals foraging in various habitats of Jammu. “Walk Slowly” (40.72%) was discerned to be their most common and preferred method of foraging followed by “Stand and Wait” (31.13%) and juveniles of Little Egret were less successful than adults in foraging. Most preferred habitat utilized by Little Egret was Lentic followed by lotic. Karl Pearson correlation coefficient was also deduced between various foraging variables which showed positive correlation between average pecks and successful attempts (r= 0.548, p<0.05) in open agricultural fields by adults. Lentic, lotic and urban habitats also recorded positive correlation viz., (r= 0.427, p<0.05), (r=0.390, p<0.05) and (r= 0.098, p<0.05) respectively between average pecks and successful attempts of adults.
Microsoft Word-Rachel C. F. Sun

This study examined the predictive effects of moral competence, prosocial norms and positive behavior recognition on school misbehavior among Chinese junior secondary school students. Results of multiple regression analysis showed that students were more likely to misbehave in school when they had lower levels of moral competence and prosocial norms, and when they perceived their positive behavior being less likely recognized. Practical implications were discussed on how to guide students to make the right choices to behave appropriately in school. Implications for future research were also discussed. Keywords—Moral competence, positive behavior recognition, prosocial norms, school misbehavior.
Reproductive Factors and Risk of Cancer of the Uterine Corpus: A Prospective Study1

Relationships between reproductive factors and risk of cancer of the uterine corpus were investigated in a prospective study of 62,079 women in Norway. A total of 420 cases were diagnosed during follow-up, from 1961 through 1980. The risk of endometrial carcinoma decreased signif icantly with increasing parity as well as with increasing age at first and last birth. The estimated odds ratio for women with 5 or more births versus uniparous was 0.60 in analyses with adjustment for age and residence characteristics. For first birth at age >35 versus <19 the odds ratio was 0.48, and for last birth at age Â¿-40versus -24 we found an odds ratio of 0.45, in analyses with additional adjustment for parity. Significant associations were also found with age at menarche and menopause, the highest risks being observed for women with early menarche or late menopause. The different reproductive variables seemed to affect the risk of sarcomas of the uterine corpus and the risk of endometrial carcinomas in a similar way.
THE SERUM OPACITY REACTION OF STREPTOCOCCUS PYOGENES THE DF_~ONSTRATION Og M~rLTn'LE, STRAIN-SeEc~IC

The serum opacity reaction of Streptococcus pyogenes (Group A streptococci), first described by Ward and Rudd (1), is associated with a lipoproteinase which acts upon the ax-lipoprotein fraction of serum to produce a measurable opalescence (2-4). Evidence of the antigenicity of streptococcal lipoproteinase in rabbits and in humans has been presented both by Krumwiede and by Rowen (2, 5). Krumwiede found that sera of rabbits immunized with filtrates of an enzyme-producing strain grown in rabbit serum inhibited the serum opacity reaction (SOR) produced by that strain. Moreover, the addition of certain human sera or a sample of human -y-globulln to horse serum-enzyme mixtures was found to prevent the splitting of serum lipoprotein by streptococcal lipoproteinase. Rowen demonstrated a substance capable of inhibiting the opalescence produced by fipoproteinase in the sera of 25-30 % of adults tested, and suggested that this inhibitory substance might be antibody. Studies by Gooder (6), by K6hier (7), and from this laboratory (8) indicate a high degree of association between lipoproteinase production and certain serotypes of Group A streptococci. Furthermore, strains of Group A streptococci which are difficult to type by the M-precipitin method are often good producers of lipoproteinase (6-8) An antigen of Group A streptococci exhibiting a close association with certain serotypes and produced by strains which are difficult to characterize pre-
Factors Associated with Adherence to Antihypertensive Treatment among Hypertensives in Urban Field Practicing Areas of Osmania Medical College, Hyderabad

Background information: Chronic non-communicable diseases are posing a serious threat to public health throughout the world, irrespective of whether developed and developing, and thus deserve to be treated as a global health priority in this new millennium. Most common non-communicable diseases are cardio-vascular diseases, for which uncontrolled hypertension is a risk factor, which is due to poor adherence to anti-hypertensive medication. Aims & Objectives: Aim:-To study the factors associated with adherence to therapy among Hypertensive subjects in Harazpenta, the urban field practice area of Community Medicine Department, Osmania Medical College, Hyderabad.
Genetic and Environmental Influences on Schizotypy: A Community-Based Twin Study

This study investigated the factor structure and etiology of four self-report schizotypy questionnaires during young adulthood (age 18-27) in 98 monozygotic and 59 same-sex dizygotic twin pairs from the community. A single phenotypic factor was identified that was primarily associated with Perceptual Aberration, Magical Ideation, and the Rust Inventory of Schizotypal Cognitions scales, and less so with Social Anhedonia. Univariate etiologic models suggested that in addition to nonshared environmental influences, Perceptual Aberration and Social Anhedonia were significantly influenced by either genes or shared family environment, whereas Magical Ideation and the Rust Inventory were influenced by shared family environment, but not genes. Multivariate twin analyses detected a common schizotypy factor, primarily defined by Perceptual Aberration, Magical Ideation, and the Rust Inventory scales, that was influenced by genes or shared environment as well as nonshared environment. Contrary to expectations, these results suggest that, at least in community-based samples, these "positive" schizotypy questionnaires are not strongly genetically influenced.
NONPARAMETRIC REGRESSION WITH NONPARAMETRICALLY GENERATED COVARIATES BY ENNO MAMMEN,

We analyze the statistical properties of nonparametric regression estimators using covariates which are not directly observable, but have be estimated from data in a preliminary step. These so-called generated covariates appear in numerous applications, including two-stage nonparametric regression, estimation of simultaneous equation models or censored regression models. Yet so far there seems to be no general theory for their impact on the final estimator’s statistical properties. Our paper provides such results. We derive a stochastic expansion that characterizes the influence of the generation step on the final estimator, and use it to derive rates of consistency and asymptotic distributions accounting for the presence of generated covariates.