Miracle-dz/UniFAR-FTUs huggingface dataset:
A 5 GHz Southern Hemisphere VLBI Survey of Compact Radio Sources. II.

We report the results of a 5 GHz Southern Hemisphere snapshot VLBI observation of a sample of blazars. The observations were performed with the Southern Hemisphere VLBI Network plus the Shanghai station in 1993 May. Twenty-three flat-spectrum, radio-loud sources were imaged. These are the first VLBI images for 15 of the sources. Eight of the sources are EGRET (>100 MeV) γ-ray sources. The milliarcsecond morphology shows a core-jet structure for 12 sources and a single compact core for the remaining 11. No compact doubles were seen. Compared with other radio images at different epochs and/or different frequencies, three core-jet blazars show evidence of bent jets, and there is some evidence for superluminal motion in the cases of two blazars. Detailed descriptions for individual blazars are given.
LncBook 2.0: integrating human long non-coding RNAs with multi-omics annotations

Abstract LncBook, a comprehensive resource of human long non-coding RNAs (lncRNAs), has been used in a wide range of lncRNA studies across various biological contexts. Here, we present LncBook 2.0 (https://ngdc.cncb.ac.cn/lncbook), with significant updates and enhancements as follows: (i) incorporation of 119 722 new transcripts, 9632 new genes, and gene structure update of 21 305 lncRNAs; (ii) characterization of conservation features of human lncRNA genes across 40 vertebrates; (iii) integration of lncRNA-encoded small proteins; (iv) enrichment of expression and DNA methylation profiles with more biological contexts and (v) identification of lncRNA–protein interactions and improved prediction of lncRNA-miRNA interactions. Collectively, LncBook 2.0 accommodates a high-quality collection of 95 243 lncRNA genes and 323 950 transcripts and incorporates their abundant annotations at different omics levels, thereby enabling users to decipher functional significance of lncRNAs in different biological contexts.
Bovine lactoferrin inhibits SARS‐CoV‐2 and SARS‐CoV‐1 by targeting the RdRp complex and alleviates viral infection in the hamster model

Breast milk has been found to inhibit coronavirus infection, while the key components and mechanisms are unknown. We aimed to determine the components that contribute to the antiviral effects of breastmilk and explore their potential mechanism. Lactoferrin (Lf) and milk fat globule membrane inhibit severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2)‐related coronavirus GX_P2V and transcription‐ and replication‐competent SARS‐CoV‐2 virus‐like particles in vitro and block viral entry into cells. We confirmed that bovine Lf (bLf) blocked the binding between human angiotensin‐converting enzyme 2 and SARS‐CoV‐2 spike protein by combining receptor‐binding domain (RBD). Importantly, bLf inhibited RNA‐dependent RNA polymerase (RdRp) activity of both SARS‐CoV‐2 and SARS‐CoV in vitro in the nanomolar range. So far, no biological macromolecules have been reported to inhibit coronavirus RdRp. Our result indicated that bLf plays a major role in inhibiting viral replication. bLf treatment reduced viral load in lungs and tracheae and alleviated pathological damage. Our study provides evidence that bLf prevents SARS‐CoV‐2 infection by combining SARS‐CoV‐2 spike protein RBD and inhibiting coronaviruses' RdRp activity, and may be a promising candidate for the treatment of coronavirus disease 2019.
An uncertainty principle for star formation - II. A new method for characterizing the cloud-scale physics of star formation and feedback across cosmic history

The cloud-scale physics of star formation and feedback represent the main uncertainty in galaxy formation studies. Progress is hampered by the limited empirical constraints outside the restricted environment of the Local Group. In particular, the poorly-quantified time evolution of the molecular cloud lifecycle, star formation, and feedback obstructs robust predictions on the scales smaller than the disc scale height that are resolved in modern galaxy formation simulations. We present a new statistical method to derive the evolutionary timeline of molecular clouds and star-forming regions. By quantifying the excess or deficit of the gas-to-stellar flux ratio around peaks of gas or star formation tracer emission, we directly measure the relative rarity of these peaks, which allows us to derive their lifetimes. We present a step-by-step, quantitative description of the method and demonstrate its practical application. The method's accuracy is tested in nearly 300 experiments using simulated galaxy maps, showing that it is capable of constraining the molecular cloud lifetime and feedback time-scale to $<0.1$ dex precision. Access to the evolutionary timeline provides a variety of additional physical quantities, such as the cloud-scale star formation efficiency, the feedback outflow velocity, the mass loading factor, and the feedback energy or momentum coupling efficiencies to the ambient medium. We show that the results are robust for a wide variety of gas and star formation tracers, spatial resolutions, galaxy inclinations, and galaxy sizes. Finally, we demonstrate that our method can be applied out to high redshift ($z\lesssim4$) with a feasible time investment on current large-scale observatories. This is a major shift from previous studies that constrained the physics of star formation and feedback in the immediate vicinity of the Sun.
GU Bootis: A New 0.6 M☉ Detached Eclipsing Binary

We have found a new low-mass, double-lined, detached eclipsing binary, GU Boo, among a sample of new variables from the ROTSE-I database. The binary has an orbital period of 0.488728 ± 0.000002 days and estimated apparent magnitudes Vrotse ≃ 13.7 and I ≃ 11.8. Our analysis of the light and radial velocity curves of the system yields individual masses and radii of M1 = 0.610 ± 0.007 M☉, M2 = 0.599 ± 0.006 M☉, R1 = 0.623 ± 0.016 R☉, and R2 = 0.620 ± 0.020 R☉. The stars in GU Boo are therefore very similar to the components of the eclipsing binary YY Gem. For this study we have adopted a mean effective temperature for the binary of Teff = 3870 ± 130 K. Based on its space velocities we suggest that GU Boo is a main-sequence binary, possibly with an age of several Gyr. The metallicity of the binary is not well constrained at this point, but we speculate that it should not be very different from solar. We have compared the physical parameters of GU Boo with current low-mass stellar models, accounting for uncertainties in age and metallicity by considering a wide range of values for those parameters. Our comparisons reveal that all the models underestimate the radii of the components of GU Boo by at least 10%-15%. This result is in agreement with the recent studies of YY Gem and CU Cnc.
PLCK G165.7+67.0: Analysis of a Massive Lensing Cluster in a Hubble Space Telescope Census of Submillimeter Giant Arcs Selected Using Planck/Herschel

We present Hubble Space Telescope WFC3-IR imaging in the fields of six apparently bright dusty star-forming galaxies (DSFGs) at z = 2–4 identified by their rest-frame far-infrared colors using the Planck and Herschel space facilities. We detect near-infrared counterparts for all six submillimeter sources, allowing us to undertake strong-lensing analyses. One field in particular stands out for its prominent giant arcs, PLCK G165.7+67.0 (G165). After combining the color and morphological information, we identify 11 sets of image multiplicities in this one field. We construct a strong-lensing model constrained by this lensing evidence, which uncovers a bimodal spatial mass distribution, and from which we measure a mass of (2.6 ± 0.11) × 1014 M⊙ within ∼250 kpc. The bright (S350 ≈ 750 mJy) DSFG appears as two images: a giant arc with a spatial extent of that is merging with the critical curve, and a lower-magnification counterimage that is detected in our new longer-wavelength ground- and space-based imaging data. Using our ground-based spectroscopy, we calculate a dynamical mass of M⊙ to the same fixed radius, although this value may be inflated relative to the true value if the velocity distribution is enhanced in the line-of-sight direction. We suggest that the bimodal mass taken in combination with the weak X-ray flux and low SZ decrement may be explained as a pre-merger for which the intracluster gas is diluted along the line of sight, while the integrated surface mass density is supercritical to strong-lensing effects.
Age prediction by deep learning applied to Greenland halibut (Reinhardtius hippoglossoides) otolith images

Otoliths (ear-stones) in the inner ears of vertebrates containing visible year zones are used extensively to determine fish age. Analysis of otoliths is a time-consuming and difficult task that requires the education of human experts. Human age estimates are inconsistent, as several readings by the same human expert might result in different ages assigned to the same otolith, in addition to an inherent bias between readers. To improve efficiency and resolve inconsistent results in the age reading from otolith images by human experts, an automated procedure based on convolutional neural networks (CNNs), a class of deep learning models suitable for image processing, is investigated. We applied CNNs that perform image regression to estimate the age of Greenland halibut (Reinhardtius hippoglossoides) with good results for individual ages as well as the overall age distribution, with an average CV of about 10% relative to the read ages by experts. In addition, the density distribution of predicted ages resembles the density distribution of the ground truth. By using k*l-fold cross-validation, we test all available samples, and we show that the results are rather sensitive to the choice of test set. Finally, we apply explanation techniques to analyze the decision process of deep learning models. In particular, we produce heatmaps indicating which input features that are the most important in the computation of predicted age.
Mapping the neutral atomic hydrogen gas outflow in the restarted radio galaxy 3C 236

The energetic feedback that is generated by radio jets in active galactic nuclei (AGNs) has been suggested to be able to produce fast outflows of atomic hydrogen (H I) gas, which can be studied in absorption at high spatial resolution. We have used the Very Large Array (VLA) and a global very long baseline interferometry (VLBI) array to locate and study in detail the H I outflow discovered with the Westerbork Synthesis Radio Telescope (WSRT) in the restarted radio galaxy 3C 236. Based on the VLA data, we confirm a blueshifted wing of the H I with a width of ~1000 km s−1. This H I outflow is partially recovered by the VLBI observation. In particular, we detect four clouds with masses of 0.28 − 1.5 × 104M⊙ with VLBI that do not follow the regular rotation of most of the H I. Three of these clouds are located, in projection, against the nuclear region on scales of ≲40 pc, while the fourth is cospatial to the southeast lobe at a projected distance of ~270 pc. Their velocities are between 150 and 640 km s−1 blueshifted with respect to the velocity of the disk-related H I. These findings suggest that the outflow is at least partly formed by clouds, as predicted by some numerical simulations, and that it originates already in the inner (few tens of pc) region of the radio galaxy. Our results indicate that the entire outflow might consist of many clouds, possibly with comparable properties as those clearly detected, but distributed at larger radii from the nucleus where the lower brightness of the lobe does not allow us to detect them. However, we cannot rule out a diffuse component of the outflow. Because 3C 236 is a low-excitation radio galaxy, it is less likely that the optical AGN is able to produce strong radiative winds. This leaves the radio jet as the main driver for the H I outflow.
Physician awareness and understanding of primary immunodeficiency disorders: a web-based study in Japan

Abstract Primary immunodeficiencies (PIDs)/Inborn errors of immunity (IEI) consist of a complex genetic group of disorders that cause susceptibility to infections, inflammation, immune dysregulation, autoimmunity, and malignancy. One of the key steps to reach an early diagnosis is improving knowledge of PID among the medical community. In this study, a web-based survey was conducted among 355 Japanese physicians, consisting of 121 pediatricians, 116 hematologists, and 118 general internal medicine physicians, to assess their awareness and knowledge about the diagnostic flow of PID. One of the major problems this study identified was the unawareness of optimal IgG trough levels among the physicians, while around half the physicians knew about the symptoms of PID. Results from the hypothetical case study revealed that over 70% of physicians considered PID after obtaining the past medical history of patients and 75.2% of physicians showed interest in gaining more knowledge about PID. The survey findings revealed that proper questioning to understand the exact medical history of patients may lead to basic immunological examination. There is a need to improve knowledge about PID, e.g., the ‘10 warning signs of PID’ and ‘4 stages of testing for PID’, and to motivate physicians to ensure earlier diagnosis of PID.
Exploring Narrow-Line Seyfert 1 Galaxies through the Physical Properties of Their Hosts

In this work we address the still open question of the nature of narrow-line Seyfert 1 galaxies (NLS1s): are they really active nuclei with lower mass black holes (BHs) than Seyfert 1 galaxies (S1s) and quasars? Our approach is based on the recently discovered physical connections between nuclear supermassive BHs and their hosting spheroids (spiral bulges or elliptical galaxies). In particular, we compare BH masses of NLS1s and S1s, analyzing the properties of their hosts by means of spectroscopic and photometric data in the optical wavelength domain. We find that NLS1s fill the low BH mass and bulge luminosity values of the MBH-MB relation, a result strongly suggesting that NLS1s are active nuclei in which less massive BHs are hosted by less massive bulges. The correlation is good, with a relatively small scatter fitting simultaneously NLS1s, S1s, and quasars. On the other hand, NLS1s seem to share the same stellar velocity dispersion range as S1s in the MBH-σ* relation, indicating that NLS1s have a smaller BH/bulge mass ratio than S1s. These two conflicting results support in any case the idea that NLS1s could be young S1s. Finally, we do not confirm the significantly nonlinear BH-bulge relation claimed by some authors.
RR Lyrae stars as standard candles in the Gaia Data Release 2 Era

We present results from the analysis of 401 RR Lyrae stars (RRLs) belonging to the field of the Milky Way (MW). For a fraction of them multi-band ($V$, $K_{\rm s}$, $W1$) photometry, metal abundances, extinction values and pulsation periods are available in the literature and accurate trigonometric parallaxes measured by the Gaia mission alongside Gaia $G$-band time-series photometry have become available with the Gaia second data release (DR2) on 2018 April 25. Using a Bayesian fitting approach we derive new near-, mid-infrared period-absolute magnitude-metallicity ($PMZ$) relations and new absolute magnitude-metallicity relations in the visual ($M_V - {\rm [Fe/H]}$) and $G$ bands ($M_G - {\rm [Fe/H]}$), based on the Gaia DR2 parallaxes. We find the dependence of luminosity on metallicity to be higher than usually found in the literature, irrespective of the passband considered. Running the adopted Bayesian model on a simulated dataset we show that the high metallicity dependence is not caused by the method, but likely arises from the actual distribution of the data and the presence of a zero-point offset in the Gaia parallaxes. We infer a zero-point offset of $-0.057$ mas, with the Gaia DR2 parallaxes being systematically smaller. We find the RR Lyrae absolute magnitude in the $V$, $G$, $K_{\rm s}$ and $W1$ bands at metallicity of [Fe/H]=$-1.5$ dex and period of P = 0.5238 days, based on Gaia DR2 parallaxes to be $M_V = 0.66\pm0.06$ mag, $M_G = 0.63\pm0.08$ mag, $M_{K_{\rm s}} = -0.37\pm0.11$ mag and $M_{W1} = -0.41\pm0.11$ mag, respectively.
Closed-loop insulin delivery: update on the state of the field and emerging technologies

ABSTRACT Introduction Over the last five years, closed-loop insulin delivery systems have transitioned from research-only to real-life use. A number of systems have been commercialized and are increasingly used in clinical practice. Given the rapidity of new developments in the field, understanding the capabilities and key similarities and differences of current systems can be challenging. This review aims to provide an update on the state of the field of closed-loop insulin delivery systems, including emerging technologies. Areas covered We summarize key clinical safety and efficacy evidence of commercial and emerging insulin-only hybrid closed-loop systems for type 1 diabetes. A literature search was conducted and clinical trials using closed-loop systems during free-living conditions were identified to report on safety and efficacy data. We comment on emerging technologies and adjuncts for closed-loop systems, as well as non-technological priorities in closed-loop insulin delivery. Expert opinion Commercial hybrid closed-loop insulin delivery systems are efficacious, consistently improving glycemic control when compared to standard therapy. Challenges remain in widespread adoption due to clinical inertia and the lack of resources to embrace technological developments by health care professionals.
Anharmonic lattice dynamics and structural phase transition of SnTe monolayer from first principles

In this work we investigate the role of quartic anharmonicity on the lattice- and thermo-dynamic properties of rectangular ( γ ) and square (β) phases of two-dimensional (2D) SnTe monolayer (ML) by using self-consistent phonon (SCP) theory, based on the first-principles calculations. For both phases, as compared to the usual harmonic approximation (HA), the renormalized phonon frequency at the optical modes (4–10) is found to be increased upon the inclusion of quartic anharmonicity via the SCP method, where the effects of cubic anharmonicity are neglected. At the experimentally observed transition temperature (T c = 270 K), the difference in the vibrational free-energy between the square and rectangular phases of SnTe ML, calculated by using the anharmonic SCP correction is found to be much closer to the structural energy gain as compared to that obtained by using only the quasi-harmonic contribution. This validates the significance of SCP approach over the HA to explain the lattice dynamics properties and predict the T c for SnTe ML and similar 2D compounds. The calculated lattice thermal conductivity of square SnTe ML (e.g. 10.67 W m−1K−1 at 300 K) is higher than that of the rectangular SnTe ML (e.g. 6.72 W m−1K−1 at 300 K) due to the relatively higher corresponding thermodynamic parameters: specific heat capacity, group velocity, and phonon lifetime obtained for the square SnTe ML. Particularly, the low energy phonon modes are found to transport most of the heat in the system and, hence, played major role to the total lattice thermal conductivity.
What If You Can’t Ask Them? Psychometric Properties of a Behavioral Assessment of Sibling Relationship Quality

Building on studies of preferences for social interaction in children with autism spectrum disorder (ASD) we sought to provide a way for siblings with ASD to express their perspective about the quality of their sibling relationships. We developed a behavioral assessment of sibling relationship preference (Sibling Relationship Assessment [SRA]) and examined the psychometric properties of test-retest reliability, inter-rater reliability, and convergent validity. The SRA was feasible to administer and revealed expected differences between sibling dyads with one sibling with ASD compared to typically-developing sibling dyads. We found strong positive correlations for inter-rater reliability and test-retest reliability and convergent validity. The SRA provides a way to assess the perspective of the sibling with ASD that taps one characteristic, preference for spending time with one’s sibling, of the quality of sibling relationships.
Growth and properties of strained VOx thin films with controlled stoichiometry

We have succeeded in growing epitaxial films of rocksalt VOx on MgO(001) substrates. The oxygen content as a function of oxygen flux was determined using O-18(2)-Rutherford backscattering spectrometry and the vanadium valence using x-ray-absorption spectroscopy. The upper and lower stoichiometry limits found are similar to those known for bulk material (0.8
Hot spring bathing accelerates wound healing and enhances heat retention effect in guinea pigs

This study aimed to demonstrate the effects of hot springs on wound healing and heat retention by performing comparative experiments with tap water. The hot spring water used in this study was from an alkaline hot spring that was rich in sodium and chloride ions and exhibited high reducibility. Guinea pigs were divided into a hot spring bathing group and a tap water bathing group, and a bathing test was conducted for eight consecutive days. A comparison of the plasma amino acid composition between the two groups after the bathing test revealed differences in the concentrations of several amino acids associated with wound healing. Image analysis demonstrated that wounds made on the abdominal skin of guinea pigs were significantly contracted by hot spring bathing compared to that by tap water bathing, and histopathological findings showed that wound healing was accelerated. In the thermography test, changes in body surface temperature after bathing were investigated in both groups. The heat retention effect was not observed in the tap water bathing group after bathing, whereas it was enhanced in the hot spring bathing group until 30 min after bathing. In conclusion, this study demonstrated that hot spring bathing accelerates wound healing and has a more significant heat retention effect than tap water bathing.
Fuel properties of Indonesian bamboo carbonized at different temperatures

Bamboo can be used in a variety of ways, including as fuel and as household and construction materials. Due to its versatility, the material is of high economic value. This study investigated the fuel properties of six bamboo species grown in Indonesia. Each bamboo sample was carbonized at different temperatures. Proximate and ultimate analyses were carried out on the bamboo samples. The thermal maturity of the bamboo samples as a solid fuel was investigated by the van Krevelen diagram. The efficiency of bamboo at each carbonizing temperature was determined based on the char yield, energy densification rate, energy efficiency, and calorific value. The results showed that the ash and fixed carbon contents of carbonized bamboo increased with an increasing carbonization temperature; while the volatile matter decreased. Significant changes in the fuel properties were observed between 200 °C and 400 °C. Carbonized bamboos showed lower sulfur contents in comparison to other fossil fuels. Ampel bamboo showed a calorific value of 18 MJ/kg to 32 MJ/kg, which was the highest value among the samples. Bamboo carbonized at temperatures above 600 °C showed a thermal maturity of coal grade. The results of this study can be used for utilizing Indonesian bamboo as a fuel source.