Miracle-dz/UniFAR-FTUs huggingface dataset:
On the formation of C iii 4647-50-51 and C iii 5696 in O star atmospheres

We investigate the formation of CIII 4647-51-50 and CIII 5696 in the atmosphere of O stars to see if they can be reliably used for abundance determinations. We use atmosphere models computed with the code CMFGEN. The key physical ingredients explaining the formation of the CIII lines are extracted from comparisons of models with different stellar parameters and through examining rates controlling the level populations. The strength of CIII 5696 critically depends on UV CIII lines at 386, 574 and 884 A. These lines control the CIII 5696 upper and lower level population. CIII 884 plays a key role in late O stars where it drains the lower level of CIII 5696. CIII 386 and CIII 574 are more important at early spectral types. The overlap of these UV lines with FeIV 386.262, FeIV 574.232 and SV 884.531 influences the radiative transfer at 386, 574 and 884 A, and consequently affects the strength of CIII 5696. CIII 4650 is mainly controlled by the CIII 538 line which acts as a drain on its lower level. FeIV 538.057 interacts with CIII 538 and has an impact on the CIII 4650 profile. Low temperature dielectronic recombinations have a negligible effect on the line profiles. Given our current understanding of the stellar and wind properties of O stars, and in view of the present results, the determination of accurate carbon abundances from CIII 4647-51-50 and CIII 5696 is an extremely challenging task. Uncertainties lower than a factor of two on C/H determinations based only on these two sets of lines should be regarder as highly doubtful. Our results provide a possible explanation of the variability of CIII 4650 in Of? p stars.
Non-adaptive measurement-based quantum computation and multi-party Bell inequalities

Quantum correlations exhibit behaviour that cannot be resolved with a local hidden variable picture of the world. In quantum information, they are also used as resources for information processing tasks, such as measurement-based quantum computation (MQC). In MQC, universal quantum computation can be achieved via adaptive measurements on a suitable entangled resource state. In this paper, we look at a version of MQC in which we remove the adaptivity of measurements and aim to understand what computational abilities remain in the resource. We show that there are explicit connections between this model of computation and the question of non-classicality in quantum correlations. We demonstrate this by focusing on deterministic computation of Boolean functions, in which natural generalizations of the Greenberger–Horne–Zeilinger paradox emerge; we then explore probabilistic computation via, which multipartite Bell inequalities can be defined. We use this correspondence to define families of multi-party Bell inequalities, which we show to have a number of interesting contrasting properties.
Disability-adjusted life years and the trends of the burden of colorectal cancer: a population-based study in Shanghai, China during 2002 to 2016

Abstract Background: Colorectal cancer (CRC) still ranks the top in morbidity and mortality of cancers worldwide, posing a huge threat and burden to the society. We aimed to determine the age-standardized incidence, mortality, and disability-adjusted life years (DALYs) of CRC and explore potential changes in the temporal trends of the CRC burden in Shanghai during 2002 to 2016. Methods: The cancer statistics and demographics were obtained from the Cancer Registry and the Statistics Bureau of Pudong New Area, respectively. Data from 2002 to 2016 were included and analyzed retrospectively. DALYs were calculated using DisMod and the age-standardized rates (ASRs) were obtained according to Segi world standard population. Joinpoint regression was used to measure the trends in CRC incidence and to estimate the annual percent change. Results: The increasing trend of CRC ASR incidence halted after 2014, coinciding with the introduction of the Shanghai CRC screening program. The ASRs of mortality and DALYs increased, at 0.42% (P < 0.05) and 4.07% (P < 0.001) per year, respectively, which were mainly driven by men and individuals aged above the CRC screening program target. Conclusions: The disease burden of CRC in Shanghai remains serious, especially among men, and individuals aged >74 years. The benefits of the screening program have been partially proven by the ASRs of CRC incidence, providing important insights into better and wider application of screening programs.
Witnessing the emergence of a carbon star

During the late stages of their evolution, Sun-like stars bring the products of nuclear burning to the surface. Most of the carbon in the Universe is believed to originate from stars with masses up to a few solar masses. Although there is a chemical dichotomy between oxygen-rich and carbon-rich evolved stars, the dredge-up itself has never been directly observed. In the last three decades, however, a few stars have been shown to display both carbon- and oxygen-rich material in their circumstellar envelopes. Two models have been proposed to explain this dual chemistry: one postulates that a recent dredge-up of carbon produced by nucleosynthesis inside the star during the Asymptotic Giant Branch changed the surface chemistry of the star. The other model postulates that oxygen-rich material exists in stable keplerian rotation around the central star. The two models make contradictory, testable, predictions on the location of the oxygen-rich material, either located further from the star than the carbon-rich gas, or very close to the star in a stable disk. Using the Faint Object InfraRed CAmera (FORCAST) instrument on board the Stratospheric Observatory for Infrared Astronomy (SOFIA) Telescope, we obtained images of the carbon-rich planetary nebula (PN) BD+30 3639 which trace both carbon-rich polycyclic aromatic hydrocarbons (PAHs) and oxygen-rich silicate dust. With the superior spectral coverage of SOFIA, and using a 3D photoionisation and dust radiative transfer model we prove that the O-rich material is distributed in a shell in the outer parts of the nebula, while the C-rich material is located in the inner parts of the nebula. These observations combined with the model, suggest a recent change in stellar surface composition for the double chemistry in this object. This is evidence for dredge-up occurring ~1000yr ago.
Involvement of Methoprene‐tolerant and Krüppel homolog 1 in juvenile hormone‐mediated vitellogenesis of female Liposcelis entomophila (End.) (Psocoptera: Liposcelididae)

Abstract Methoprene‐tolerant (Met) as an intracellular receptor of juvenile hormone (JH) and the Krüppel‐homolog 1 (Kr‐h1) as a JH‐inducible transcription factor had been proved to contribute to insect reproduction. Their functions vary in different insect orders, however, they are not clear in Psocoptera. In this study, LeMet and LeKr‐h1 were identified and their roles in vitellogenesis and ovarian development were investigated in Liposcelis entomophila (Enderlein). Treatment with exogenous JH III significantly induced the expression of LeKr‐h1, LeVg, and LeVgR. Furthermore, silencing LeMet and LeKr‐h1 remarkably reduced the transcription of LeVg and LeVgR, disrupted the production of Vg in fat body and the uptake of Vg by oocytes, and ultimately led to a decline in fecundity. The results indicated that the JH signaling pathway was essential to the reproductive process of this species. Interestingly, knockdown of LeMet or LeKr‐h1 also resulted in fluctuations in the expression of FoxO, indicating the complex regulatory interactions between different hormone factors. Besides, knockdown of both LeMet and LeKr‐h1 significantly increased L. entomophila mortality. Our study provides initial insight into the roles of JH signaling in the female reproduction of psocids and provided evidence that RNAi‐mediated knockdown of Met or Kr‐h1 is a potential pest control strategy.
An Investigation of the Mechanisms of Wind Generated Surface Waves

1 Acknowledgments . 3 Table of Content . 4 Nomenclature . 7 Chapter 1. 11 Effect of the physical properties of water on the wave generation mechanism . 11 I Background . 11 II Wind generated surface wave theories . 12 II
Atypical brain network development of infants at elevated likelihood for autism spectrum disorder during the first year of life

Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by behavioral features that appear early in life. Although studies have shown that atypical brain functional and structural connectivity are associated with these behavioral traits, the occurrence and initial alterations of brain networks have not been fully investigated. The current study aimed to map early brain network efficiency and information transferring in infants at elevated likelihood (EL) compared to infants at typical likelihood (TL) for ASD in the first year of life. This study used a resting‐state functional near‐infrared spectroscopy (fNIRS) approach to obtain the length and strength of functional connections in the frontal and temporal areas in 45 5‐month‐old and 38 10‐month‐old infants. Modular organization and small‐world properties were detected in both EL and TL infants at 5 and 10 months. In 5‐month‐old EL infants, local and nodal efficiency were significantly greater than age‐matched TL infants, indicating overgrown local connections. Furthermore, we used a support vector machine (SVM) model to classify infants with or without EL based on the obtained global properties of the network, achieving an accuracy of 77.6%. These results suggest that infants with EL for ASD exhibit inefficiencies in the organization of brain networks during the first year of life.
Dynamic changes and prognosis of pulmonary congestion by lung ultrasound in hemodialysis patients: a systematic review and meta-analysis.

AIMS Lung ultrasound (LUS) has been rapidly developed to evaluate pulmonary extravascular fluid. A systematic review was conducted to study the dynamic changes of LUS findings of pulmonary congestion before and after hemodialysis and examine the application of LUS for the prognosis of hemodialysis patients. MATERIAL AND METHODS This study searched online databases for articles on hemodialysis patients that used LUS to evaluate dynamic changes during hemodialysis or prognosis. Articles published in English or Chinese until September 2021 with ≥30 patients were included in this study. RESULTS Of the 1329 articles, 14 met the inclusion criteria: 9 reported dynamic changes during dialysis in LUS (438 patients), and 5 reported the prognosis of hemodialysis patients in LUS (1274 patients). As indicated by a further meta-analysis, eight studies found that the combined standardized effect size was -0.74. The all-cause mortality rate of the dialysis patient group with high B-line scores was three times that of the dialysis patient group with low B-line scores. In dialysis patients, no difference was found between the LUS guided treatment and the conventional care in reducing the all-cause mortality (HR=0.92 95%CI: 0.67-1.27) and cardiovascular events (HR=0.98 95%CI: 0.72 -1.34). CONCLUSIONS LUS can be used to effectively evaluate the volume status of hemodialysis patients in real time. The level of B-line before dialysis is significantly correlated with the poor prognosis. However, compared with the routine nursing group, the treatment of hemodialysis patients with LUS-guided volume management cannot effectively reduce mortality and cardiovascular events.
Seladelpar: an investigational drug for the treatment of early-stage primary biliary cholangitis (PBC)

ABSTRACT Introduction Generic fibrates are used off-label as add-in therapy for the management of primary biliary cholangitis (PBC) but with unproven long-term liver-related survival benefits. The recently developed fibrate, seladelpar, has shown promising results in clinical trials, but these outcomes have been previously marred by safety concerns. Areas covered We summarize existing treatment options in PBC and evaluate current trial data for seladelpar in relation to liver biochemistry, symptomology, and safety. Expert opinion Seladelpar leads to marked improvement in liver biochemistry and may improve symptoms. Safety concerns around liver toxicity appear to have been addressed. With likely increasing evidence compared to existing off-label fibrates, seladelpar has the potential as an attractive future second-line agent in PBC.
Higher dimensional Zariski decompositions

Using currents with minimal singularities, we construct pointwise minimal multiplicities for a real pseudo-effective $(1,1)$-class $\alpha$ on a compact complex $n$-fold $X$, which are the local obstructions to the numerical effectivity of $\alpha$. The negative part of $\alpha$ is then defined as the real effective divisor $N(\alpha)$ whose multiplicity along a prime divisor $D$ is just the generic multiplicity of $\alpha$ along $D$, and we get in that way a divisorial Zariski decomposition of $\alpha$ into the sum of a class $Z(\alpha)$ which is nef in codimension 1 and the class of its negative part $N(\alpha)$, which is exceptional in the sense that it is very rigidly embedded in $X$. The positive parts $Z(\alpha)$ generate a modified nef cone, and the pseudo-effective cone is shown to be locally polyhedral away from the modified nef cone, with extremal rays generated by exceptional divisors. We then treat the case of a surface and a hyper-K\"ahler manifold in some detail: under the intersection form (resp. the Beauville-Bogomolov form), we characterize the modified nef cone and the exceptional divisors; our divisorial Zariski decomposition is orthogonal, and is thus a rational decomposition, which fact accounts for the usual existence statement of a Zariski decomposition on a projective surface, which is thus extended to the hyper-K\"ahler case. Finally, we explain how the divisorial Zariski decomposition of (the first Chern class of) a big line bundle on a projective manifold can be characterized in terms of the asymptotics of the linear series $|kL|$ as $k\to\infty$.
Telomere length and mitochondrial DNA copy number in bipolar disorder: A sibling study

Abstract Objectives An accelerated cellular ageing has been observed in bipolar disorder (BD) using biomarkers such as telomere length (TL) and mitochondrial DNA copy number (mtDNAcn). Several risk factors might drive premature ageing in individuals with BD, including a familial predisposition. This study compared TL and mtDNAcn between individuals with BD and their (un)-affected siblings, and explored factors that may explain proband-sibling differences. Methods Sixty individuals with BD and seventy-four siblings (34 affected with BD or mood disorders and 40 unaffected) were included. Quantitative polymerase chain reaction (qPCR) was used to measure TL and mtDNAcn from peripheral blood genomic DNA. Results TL and mtDNAcn did not significantly differ between probands and their siblings, whatever these latter were affected or not with mood disorders. However, the correlation plots of TL or mtDNAcn in proband-sibling pairs suggested that some pairs were discordant. The within proband-sibling pairs differences for TL and mtDNAcn were not explained by differences in all tested factors. Conclusions This study shows that probands with BD and their siblings are concordant for TL and mtDNAcn suggesting that they may share some environmental or genetic determinants of these two biomarkers of cellular ageing.
The association between steatosis and liver damage in transfusion‐dependent beta thalassaemia patients

Non‐alcoholic fatty liver disease (NAFLD) is a global health problem. Iron is the leading cause of liver damage in patients with transfusion‐dependent thalassaemia (TDT), and data on the contribution of NAFLD to liver damage in TDT is lacking. Forty‐five heavily transfused TDT patients who did not have biochemical or ultrasonic evidence of liver cirrhosis were evaluated for effects of iron overload, including the presence of diabetes mellitus, hypogonadism, serum ferritin, R2‐MRI‐liver, and liver enzymes alanine aminotransferase and aspartate aminotransferase. Liver fibrosis and steatosis were estimated using transient elastography (TE). Nine (20%) patients had significant steatosis (S1), and their body mass index (BMI) and liver fibrosis scores were higher than in patients without significant steatosis (S0) (p = 0.03 and p = 0.004, respectively). On regression analysis, the controlled attenuation parameter (CAP) score (i.e., degree of liver steatosis) was associated only with increasing BMI. The TE score (i.e., degree of liver fibrosis) was associated with increasing age, CAP score, male gender, and presence of diabetes. Neither liver steatosis nor fibrosis showed significant association with the liver iron concentration or iron‐related organ damage (hypogonadism). In this cohort of TDT patients, steatosis of the liver, which is associated with increasing BMI, appeared to increase the risk of liver fibrosis.
SWIFT COALESCENCE OF SUPERMASSIVE BLACK HOLES IN COSMOLOGICAL MERGERS OF MASSIVE GALAXIES

Supermassive black holes (SMBHs) are ubiquitous in galaxies with a sizable mass. It is expected that a pair of SMBHs originally in the nuclei of two merging galaxies would form a binary and eventually coalesce via a burst of gravitational waves. So far, theoretical models and simulations, focusing only on limited phases of the orbital decay of SMBHs under idealized conditions of the galaxy hosts, have been unable to directly predict the SMBH merger timescale from ab-initio galaxy formation theory. The predicted SMBH merger timescales are long, of order Gyrs, which could be problematic for future gravitational wave (GW) searches. Here, we present the first multi-scale ΛCDM cosmological simulation that follows the orbital decay of a pair of SMBHs in a merger of two typical massive galaxies at , all the way to the final coalescence driven by GW emission. The two SMBHs, with masses , settle quickly in the nucleus of the merger remnant. The remnant is triaxial and extremely dense due to the dissipative nature of the merger and the intrinsic compactness of galaxies at high redshift. Such properties naturally allow a very efficient hardening of the SMBH binary. The SMBH merger occurs in only ∼10 Myr after the galactic cores have merged, which is two orders of magnitude smaller than the Hubble time.
Modified magnetohydrodynamics around the electroweak transition

We analyse solutions of the MHD equations around the electroweak transition taking into account the effects of the chiral anomaly. It is shown that a transition that is not of the first order has direct consequences on the evolution of the asymmetry between left- and right-handed leptons. Assuming an initial chiral asymmetry in the symmetric phase at temperatures higher than the transition temperature, as well as the existence of magnetic fields, it is demonstrated that the asymmetry typically grows with time, until it undergoes a fast decrease at the transition, and then eventually gets damped at lower temperatures in the broken phase. We argue that it is unlikely to have any significant magnetic field amplification as a consequence of the electroweak transition in the Standard model, even when the chiral anomaly is introduced. The presence of a chiral asymmetry between left- and right-handed charge carriers naturally leads to the creation of helical magnetic fields from non-helical fields and this can have consequences on their subsequent evolution. Similarly, an initially vanishing chiral asymmetry is naturally created in the presence of a helical magnetic field.
Ribonucleoprotein transport in Negative Strand RNA viruses

Negative‐sense, single‐stranded RNA (‐ssRNA) viruses comprise some of the deadliest human pathogens (Ebola, rabies, influenza A viruses etc.). Developing therapeutic tools relies on a better understanding of their multiplication cycle. For these viruses, the genome replication and transcription activities most‐often segregate in membrane‐less environments called inclusion bodies (IBs) or viral factories. These “organelles” usually locate far from the cell surface from where new virions are released, and ‐ssRNA viruses do not encode for transport factors. The efficient trafficking of the genome progeny toward the cell surface is most often ensured by mechanisms co‐opting the cellular machineries.
A single-cell mass cytometry platform to map the effects of preclinical drugs on cartilage homeostasis

No disease-modifying drug exists for osteoarthritis (OA). Despite success in animal models, candidate drugs continue to fail in clinical trials owing to the unmapped interpatient heterogeneity and disease complexity. We used a single-cell platform based on cytometry by time-of-flight (cyTOF) to precisely outline the effects of candidate drugs on human OA chondrocytes. OA chondrocytes harvested from patients undergoing total knee arthroplasty were treated with 2 drugs, an NF-κB pathway inhibitor, BMS-345541, and a chondroinductive small molecule, kartogenin, that showed preclinical success in animal models for OA. cyTOF conducted with 30 metal isotope–labeled antibodies parsed the effects of the drugs on inflammatory, senescent, and chondroprogenitor cell populations. The NF-κB pathway inhibition decreased the expression of p–NF-κB, HIF2A, and inducible NOS in multiple chondrocyte clusters and significantly depleted 4 p16ink4a-expressing senescent populations, including NOTCH1+STRO1+ chondroprogenitor cells. While kartogenin also affected select p16ink4a-expressing senescent clusters, there was a less discernible effect on chondroprogenitor cell populations. Overall, BMS-345541 elicited a uniform drug response in all patients, while only a few responded to kartogenin. These studies demonstrate that a single-cell cyTOF-based drug screening platform can provide insights into patient response assessment and patient stratification.
Early death in a mouse model of Alzheimer’s disease exacerbated by microglial loss of TAM receptor signaling

Significance Most patients with Alzheimer’s disease (AD), a neurodegenerative disorder that leads to severe cognitive decline, suffer from concomitant seizures. These events also occur in mouse models of AD in which amyloid beta peptides are overproduced and are often lethal. Here we report the surprising finding that mutations in the TAM receptor tyrosine kinase system greatly exacerbate the incidence of lethal seizures in the APP/PS1 mouse AD model. This exacerbation is tied to TAM activity in microglia during adult neurogenesis in the hippocampus, a trigger site for seizures generally, and results in the development of exuberant excitatory synapses in this critical brain region.
C–H Activation by Isolable Cationic Bis(phosphine) Cobalt(III) Metallacycles

Five- and six-coordinate cationic bis(phosphine) cobalt(III) metallacycle complexes were synthesized with the general structures, [(depe)Co(cycloneophyl)(L)(L′)][BArF4] (depe = 1,2-bis(diethylphosphino)ethane; cycloneophyl = [κ-C:C-(CH2C(Me)2)C6H4]; L/L′ = pyridine, pivalonitrile, or the vacant site, BAr4F = B[(3,5-(CF3)2)C6H3]4). Each of these compounds promoted facile directed C(sp2)–H activation with exclusive selectivity for ortho-alkylated products, consistent with the selectivity of reported cobalt-catalyzed arene-alkene-alkyne coupling reactions. The direct observation of C–H activation by cobalt(III) metallacycles provided experimental support for the intermediacy of these compounds in this class of catalytic C–H functionalization reaction. Deuterium labeling and kinetic studies provided insight into the nature of C–H bond cleavage and C–C bond reductive elimination from isolable cobalt(III) precursors.