Miracle-dz/UniFAR-FTUs huggingface dataset:
The potential effects of COVID-19 lockdown and the following restrictions on the status of eight target stocks in the Adriatic Sea

The COVID-19 pandemic had major impacts on the seafood supply chain, also reducing fishing activity. It is worth asking if the fish stocks in the Mediterranean Sea, which in most cases have been in overfishing conditions for many years, may have benefitted from the reduction in the fishing pressure. The present work is the first attempt to make a quantitative evaluation of the fishing effort reduction due to the COVID-19 pandemic and, consequently, its impact on Mediterranean fish stocks, focusing on Adriatic Sea subareas. Eight commercially exploited target stocks (common sole, common cuttlefish, spottail mantis shrimp, European hake, red mullet, anchovy, sardine, and deepwater pink shrimp) were evaluated with a surplus production model, separately fitting the data for each stock until 2019 and until 2020. Results for the 2019 and 2020 models in terms of biomass and fishing mortality were statistically compared with a bootstrap resampling technique to assess their statistical difference. Most of the stocks showed a small but significant improvement in terms of both biomass at sea and reduction in fishing mortality, except cuttlefish and pink shrimp, which showed a reduction in biomass at sea and an increase in fishing mortality (only for common cuttlefish). After reviewing the potential co-occurrence of environmental and management-related factors, we concluded that only in the case of the common sole can an effective biomass improvement related to the pandemic restrictions be detected, because it is the target of the only fishing fleet whose activity remained far lower than expectations for the entire 2020.
Analysis of serum bone turnover markers in female cynomolgus monkeys of different ages

Objective The purpose of this study was to examine bone turnover markers, estradiol, parathyroid hormone, and 25 hydroxyvitamin D, in cynomolgus monkeys at different ages to improve our understanding of the changes in bone turnover markers throughout the life cycle of cynomolgus monkeys and to provide a basis for the establishment of a non-human primate model of osteoporosis. Methods Total Body Bone Mineral Density and Total Body Bone Mineral Content were measured using Dual-Energy X-Ray Absorptiometry in cynomolgus monkeys at different ages. Serum bone turnover marker' levels were measured using enzyme immunoassays at each age group, and the relationship between bone turnover markers and age was assessed by Spearman rank correlation analysis to investigate the relationship between bone turnover markers and age in female cynomolgus monkeys. Results Total Body Bone Mineral Density in female cynomolgus monkeys peaked at 10 years of age and then formed a plateau that was maintained until old age. Procollagen I Aminoterminal Propeptide, Bone Alkaline Phosphatase, Osteocalcin, and C-Terminal Telopeptide Of Type I Collagen peaked at 1 to 3 years of age and gradually decreased with age, leveling off by 10 years of age. Estradiol, parathyroid hormone, and 25 hydroxyvitamin D, follicle-stimulating hormone, luteinizing hormone, were not significantly different among age groups. Conclusion This paper provides data on trends in bone turnover markers throughout the life cycle of female cynomolgus monkeys, which are similar to human changes.
Exploring inclusive education in times of COVID-19: An international comparison of German, Austrian and Portuguese teachers

With the start of the Coronavirus (COVID-19) pandemic, the global education system has a faced immense challenges and disruptions resulting in and the necessity for an immediate redesign of teaching and learning in the school context. Face-to-face classroom instruction had to be replaced by ‘emergency remote teaching’, requiring teacher to adapt their daily routines to a new and unprecedented educational reality. Researchers and policymakers worldwide have agreed that, despite the fact that efforts were made to immediately adapt to emergency remote teaching, disadvantaged and vulnerable students may be especially at risk in emergency remote teaching. Given the differences in schooling organization across countries during the COVID-19 pandemic it can be expected that teachers performed inclusive instructional practices significantly different. Against the unpredictable situation, cross-country research has been urgently required to provide data that could inform education policy. Thus, this study explored teachers’ perceptions of supporting at risk students during the first COVID-19 school closures, as well as examining teachers’ inclusive teaching practices in three countries: Germany, Austria and Portugal. ANOVA results revealed important country differences. In general, it appears that teachers in Germany and Austria reported to have implemented less practices to address vulnerable and at-risk students compared to Portuguese teachers. Implications of the results, as well as further lines of research are outlined.
X‐ray evidence for the accretion disc–outflow connection in 3C 111

ABSTRACT We present the spectral analysis of three Suzaku X-ray Imaging Spectrometer observations of 3C III requested to monitor the predicted variability of its ultrafast outflow on -7 d time-scales. We detect an ionized iron emission line in the first observation and a blueshifted absorption line in the second, when the flux is "'-'30 per cent higher. The location of the material is constrained at <0.006 pc from the variability. Detailed modelling supports an identification with ionized reflection off the accretion disc at -20-100r, from the black hole and a highly ionized and massive ultrafast outflow with velocity . a.le. respectively. The outft.ow is most probably accelerated by radiation pressure, but additional magnetic thrust cannot be excluded. The measured high outflow rate and mechanical energy support the claims that disc outflows may have a significant feedback role. This work provides the first direct evidence for an accretion disc-outflow connection in a radio-loud active galactic nuc1eus. possibly linked also to the jet activity. Key words: accretion. accretion discs - hlack hole physics - galaxies: active. 1 INTRODUCTION There are several indirect pieces of observational
In-situ trace element and S isotope systematics in pyrite from three porphyry-epithermal prospects, Limnos Island, Greece

Porphyry-epithermal systems associated with high-K calc-alkaline to alkaline igneous host rocks may be prospective for the recovery of Te among related elements like Cu, Ag, and Au. Limnos Island, as part of the Tethyan magmatic belt, is such an example, where (telescoped) porphyry-epithermal mineralization is accompanied by different alteration-styles reflecting various hydrothermal processes. Here, we present in-situ S isotope and trace element data of pyrite, which records the fluid evolution from the early porphyry to the late epithermal stage in three distinct prospects (Fakos, Kaspakas, Sardes) on Limnos Island. Pyrite in the sericitic alteration of Fakos mainly formed from single-phase magma-derived fluids lacking evidence for phase separation, as reflected by relatively constant δ34S (about −4‰) and Co/Ni (0.1-1) values. By contrast, in the sericitic alteration of Kaspakas and the following epithermal stages, an influence of boiling is implied by negative δ34S values to −15‰, significant intergrain δ34S variations (>3‰), highly variable Co/Ni (100-0.01) and As/Co (10-0.001) in pyrite. Higher δ34S values (above −4‰) in porphyry pyrite from Sardes and partly in the other two hydrothermal systems are related to mixing between magmatic S, and S which was transported through deeply circulated seawater and/or meteoric water. We propose that fluid-rock interaction buffered the pH to higher values, which enhanced the solubility of Au and Te. Subsequent boiling processes caused the Au deposition, whereas Te partitioned into the vapor and finally precipitated upon condensation into meteoric water. This process is accompanied by continuous cooling during fluid ascent from 780°C to <300°C, as indicated by increasing Sb, Tl, and Pb in pyrite from the porphyry to the epithermal stage. Consequently, the in situ δ34S and trace element analysis allows to constrain the depositional environment of economic metals like Au and Te in porphyry-epithermal prospects.
Magnitude of episiotomy practice and associated factors among women who gave birth at Hiwot Fana Specialized University Hospital, Eastern Ethiopia

Background Episiotomy is an intentional surgical incision made on the perineum with the aim of enlarging the introits during the second stage of labor or just before delivery of the baby. It sometimes also interferes with the mother's comfort during the postpartum period and has associated complications especially when it is done without indication. However, there is limited information regarding episiotomy practice in the study area. Objective This study aimed to determine the magnitude of episiotomy practice and associated factors among women who gave birth at the Hiwot Fana Specialized University Hospital, Eastern Ethiopia, 2021. Methods A facility-based cross-sectional study was conducted among 408 systematically selected mothers who gave birth at the Hiwot Fana Specialized University Hospital, from 1 January to 30 December 2021. Datas were collected from delivery medical records using a pretested checklist. The extracted data were checked, coded, and entered into the Epi-data version 3.1 and exported to the STATA version 16 software for analysis. Binary logistic regression was fitted to identify factors associated with episiotomy practice. P-values < 0.05 were considered to declare the presence of statistical significance. Results The overall prevalence of episiotomy practice was found to be 43.4 % (95% CI: 38.7, 48.9), and mediolateral was the most commonly practiced episiotomy type (41.4%). Parity [AOR: 6.2; 95% CI (3.8–17.6)], 1st min Apgar score [AOR: 1.6; 95% CI (1.04–2.67)], presence of maternal medical disease [AOR: 3.3; 95% CI (1.09–6.9)], and induced labor [AOR: 1.6; 95%CI (1.12, 4.13)] were significantly associated with the episiotomy practice. Conclusion The prevalence of episiotomy practice in the study area was high. Parity, presence of maternal medical disease, induction of labor, and 1st min APGAR score were significant factors associated with episiotomy practice. Considering the presence of appropriate indications or preventing unjustifiable indications, can help to reduce the current high practice rates.
New 8-prenylated quercetin glycosides from the flowers of Epimedium acuminatum and their testosterone production-promoting activities

Phytochemical investigation was carried out for the flowers of Epimedium acuminatum Franchet. by first conducting LC-MS analysis, leading to the identification of 32 compounds. Furthermore, guided by LC-MS profiling, three new 8-prenylated quercetin glycosides (3′-hydroxylikarisoside C, 3′-hydroxylepimedoside E, 3′-hydroxyldiphylloside B), one new anthocyanin (delphinidin-3-O-p-coumaroyl-sophoroside) and six known compounds were isolated from the flowers of E. acuminatum for the first time, and their structures were characterized based on spectroscopic methods including 1D and 2D NMR, and HRESIMS. Combining our discoveries and literature survey, a revised classification of Epimedium flavonols was proposed as Type A (8-prenylated kaempferol based), which was further subdivided into subtype icaritin and subtype demethylicaritin, and Type B (8-prenylated quercetin based), which was further subdivided into subtype 3′-hydroxylicaritin and subtype 3′-hydroxyldemethylicaritin. The structure-activity relationship (SAR) study was carried out by comparing testosterone production-promoting activities of all the new compounds along with nine related Epimedium flavonols, revealing that the new 8-prenylated quercetin glycosides (subtype 3′-hydroxyldemethylicaritin in Type B) exhibited lower testosterone production-promoting activities in rat primary Leydig cells than Epimedium flavonols of subtype demethylicaritin in Type A, but possessed higher activities than the Epimedium flavonols of subtype icaritin in Type A. These results suggested that either methylation at C-4′ position or hydroxylation at C-3′ position of ring B could significantly reduce the testosterone production-promoting activities of Epimedium flavonols. Graphical Abstract
Comparison of two behavioral tests for tinnitus assessment in mice

Animal research focused on chronic tinnitus associated with noise-induced hearing loss can be expensive and time-consuming as a result of the behavioral training required. Although there exist a number of behavioral tests for tinnitus; there have been few formal direct comparisons of these tests. Here, we evaluated animals in two different tinnitus assessment methods. CBA/CaJ mice were trained in an operant conditioning, active avoidance (AA) test, and a reflexive, gap-induced pre-pulse inhibition of acoustic startle (GPIAS) test, or both. Tinnitus was induced in awake mice by unilateral continuous sound exposure using a 2-kHz- or 12 octave-wide noise centered at 16 kHz and presented at 113- or 116-dB SPL. Tinnitus was assessed 8 weeks after sound overexposure. Most mice had evidence of tinnitus behavior in at least one of the two behaviors. Of the mice evaluated in AA, over half (55%) had tinnitus positive behavior. In GPIAS, fewer animals (13%) were positive than were identified using the AA test. Few mice were positive in both tests (10%), and only one was positive for tinnitus behavior at the same spectral frequency in both tests. When the association between tinnitus behavior and spontaneous activity recorded in the inferior colliculus was compared, animals with tinnitus behavior in AA exhibited increased spontaneous activity, while those positive in GPIAS did not. Thus, it appears that operant conditioning tests, like AA, maybe more reliable and accurate tests for tinnitus than reflexive tests.
Constraining the star formation and the assembly histories of normal and compact early-type galaxies at 1 < z < 2

We present a study based on a sample of 62 early-type galaxies (ETGs) at 0.9 5. Earlier stars, those formed at zform > 5, are assembled in compact and more massive ( M⊙) ETGs, while stars formed later (zform≲ 3) or resulting from subsequent episodes of star formation are assembled both in compact and in normal ETGs. Thus, the older the stellar population, the higher the mass of the hosting galaxy but not vice versa. This suggests that the epoch of formation may play a role in the formation of massive ETGs rather than the mass itself. We show that the possible general scheme in which normal ETGs at 〈z〉≃ 1.5 are descendants of compact spheroids assembled at higher redshift is not compatible with the current models. Indeed, we find that the number of dry mergers expected in a hierarchical model is almost two orders of magnitude lower than that needed to enlarge a compact ETG up to a normal-size ETG. Moreover, we do not find evidence supporting a dependence of the compactness of galaxies on their redshift of assembly, a dependence expected in the hypothesis that the compactness of a galaxy is due to the higher density of the Universe at earlier epochs. Finally, we propose a simple scheme of formation and assembly of the stellar mass of ETGs based on dissipative gas-rich merger, which can qualitatively account for the coexistence of normal and compact ETGs observed at 〈z〉≃ 1.5 in spite of the same stellar mass, the lack of normal ETGs with high zform and the absence of correlation between compactness, stellar mass and formation redshift.
The impact of harmonization on radiomic features in Parkinson’s disease and healthy controls: A multicenter study

Radiomics is a challenging development area in imaging field that is greatly capturing interest of radiologists and neuroscientists. However, radiomics features show a strong non-biological variability determined by different facilities and imaging protocols, limiting the reproducibility and generalizability of analysis frameworks. Our study aimed to investigate the usefulness of harmonization to reduce site-effects on radiomics features over specific brain regions. We selected T1-weighted magnetic resonance imaging (MRI) by using the MRI dataset Parkinson’s Progression Markers Initiative (PPMI) from different sites with healthy controls (HC) and Parkinson’s disease (PD) patients. First, the investigation of radiomics measure discrepancies were assessed on healthy brain regions-of-interest (ROIs) via a classification pipeline based on LASSO feature selection and support vector machine (SVM) model. Then, a ComBat-based harmonization approach was applied to correct site-effects. Finally, a validation step on PD subjects evaluated diagnostic accuracy before and after harmonization of radiomics data. Results on healthy subjects demonstrated a dependence from site-effects that could be corrected with ComBat harmonization. LASSO regressor after harmonization was unable to select any feature to distinguish controls by site. Moreover, harmonized radiomics features achieved an area under the receiving operating characteristic curve (AUC) of 0.77 (compared to AUC of 0.71 for raw radiomics measures) in distinguish Parkinson’s patients from HC. We found a not-negligible site-effect studying radiomics of HC pre- and post-harmonization of features. Our validation study on PD patients demonstrated a significant influence of non-biological noise source in diagnostic performances. Finally, harmonization of multicenter radiomic data represent a necessary step to make analysis pipelines reliable and replicable for multisite neuroimaging studies.
Abnormal synergies and associated reactions post-hemiparetic stroke reflect muscle activation patterns of brainstem motor pathways

Individuals with moderate-to-severe post-stroke hemiparesis cannot control proximal and distal joints of the arm independently because they are constrained to stereotypical movement patterns called flexion and extension synergies. Accumulating evidence indicates that these synergies emerge because of upregulation of diffusely projecting brainstem motor pathways following stroke-induced damage to corticofugal pathways. During our recent work on differences in synergy expression among proximal and distal joints, we serendipitously observed some notable characteristics of synergy-driven muscle activation. It seemed that: paretic wrist/finger muscles were activated maximally during contractions of muscles at a different joint; differences in the magnitude of synergy expression occurred when elicited via contraction of proximal vs. distal muscles; and associated reactions in the paretic limb occurred during maximal efforts with the non-paretic limb, the strength of which seemed to vary depending on which muscles in the non-paretic limb were contracting. Here we formally investigated these observations and interpreted them within the context of the neural mechanisms thought to underlie stereotypical movement patterns. If upregulation of brainstem motor pathways occurs following stroke-induced corticofugal tract damage, then we would expect a pattern of muscle dependency in the observed behaviors consistent with such neural reorganization. Twelve participants with moderate-to-severe hemiparetic stroke and six without stroke performed maximal isometric torque generation in eight directions: shoulder abduction/adduction and elbow, wrist, and finger flexion/extension. Isometric joint torques and surface EMG were recorded from shoulder, elbow, wrist, and finger joints and muscles. For some participants, joint torque and muscle activation generated during maximal voluntary contractions were lower than during maximal synergy-induced contractions (i.e., contractions about a different joint), particularly for wrist and fingers. Synergy-driven contractions were strongest when elicited via proximal joints and weakest when elicited via distal joints. Associated reactions in the wrist/finger flexors were stronger than those of other paretic muscles and were the only ones whose response depended on whether the non-paretic contraction was at a proximal or distal joint. Results provide indirect evidence linking the influence of brainstem motor pathways to abnormal motor behaviors post-stroke, and they demonstrate the need to examine whole-limb behavior when studying or seeking to rehabilitate the paretic upper limb.
Protoplanetary Disks of T Tauri Binary Systems in the Orion Nebula Cluster

Aims. We present a study of protoplanetary disks in spatially resolved low-mass binary stars in the well-known Orion Nebula Cluster (ONC) to assess the impact of binarity on the properties of circumstellar disks. This is currently the largest such study in a clustered high-stellar-density star-forming environment, as opposed to previous studies, which have mostly been focussed on the young, lowstellar-density Taurus association. We particularly aim t o determine the presence of magnetospheric accretion and dust disks for each binary component, and measure the overall disk frequency. Methods. We carried out spatially resolved adaptive-optics-assist ed observations to acquire near-infrared photometry and spectroscopy of 26 binaries in the ONC, and determine stellar parameters such as effective temperatures, spectral types, luminosities, and masses, as well as accretion properties and near-infrared excesses for the individual binary components. On the basis of our medium resolution K-band spectroscopy, we infer the presence of magnetospheric accretion around each binary component by measuring the strength of the Brackett-γ emission. The accretion disk frequency among the ONC binaries is then estimated from Bayesian statistics. The observed disk signatures, measured accret ion luminosities, and mass accretion rates are investigate d with respect to the binary separation, mass ratios, and distance to the center o f the ONC. Results. A fraction of 40 +10 −9 % of the binary components in the sample can be inferred to be T Tauri stars possessing an accretion disk. This is only marginally smaller than the disk fraction of single stars of∼50% in the ONC. We find that disks in wide binaries of >200 AU separation are consistent with random pairing, while the evolution of circumprimary and circumsecondary disks is observed to be synchronized in close binaries (separations <200AU). Circumbinary disks appear to be unsuitable to explain this difference. Furthermore, we identify several mixed pairs of accreting and non-accreting components, suggesting that these systems are common and that there is no preference for either the more or less massive component to evolve faster. The derived accretion luminosities and mass accretion rates of the ONC binary components are of similar magnitude as those for both ONC single stars and binaries in the Taurus star-forming region. The paper concludes with a discussion of the (presumably weak) connection between the presence of inner accretion disks in young binary systems and the existence of planets in stellar multiples.