Miracle-dz/UniFAR-FTUs huggingface dataset:
CCID_A_318802 1017..1022

1European Market Maintenance Assessment, Patients Priority Dpt, Fontenay sous-bois, France; 2NAOS, Research and Development, Lyon, France Introduction: The results from the “Objectifs Peau” project showed that approximately 30% of the French population complains of an unpleasant skin sensation at least once a day. Itching was the most frequent complaint (32%), followed by tingling (18.9%) and burning sensation (5.6%), which impact an individual’s daily life. These sensations could be identified, as they were either isolated or associated with each other. The aim of this study was to evaluate the use of micellar solution to reduce these sensations, especially on sensitive skin. Methodology: A questionnaire was administered at Day 0 (D0), D2, D14, and D28 using a mobile phone application to individuals applying micellar solution (Sensibio H2O, Laboratoire Bioderma, NAOS) who spontaneously used micellar solution for sensitive skin and/or spontaneously consulted a health professional. Itching, tightness, tingling and burning sensations were evaluated by means of frequencies (never, rarely, sometimes, often or constantly) at D0, D2, D14 and D28. Responses from the questionnaire were rated (never=0, rarely=1, sometimes=2, often=3 or constantly=4) and allowed us to obtain an overall “unpleasant sensations” score, where a higher score corresponded to a higher degree of unpleasant sensations. Results: In total, 400 evaluable individuals participated in the study (97% female, average age 38.5±13 years, 82% reported sensitive skin). The “unpleasant sensations” score improved from D2 and continued significantly on D14 and D28. The improvement rates were 47.7%, 57.9% and 62.7% at D2, D14 and D28, respectively, compared to D0. The percentages of improvement at D2, D14 and D28 were 83.2% (95% CI: 79.26; 87.21), 87.54% (95% CI: 84.01; 91.06) and 90% (95% CI: 87.06; 92.94), respectively, compared to D0. Conclusion: The improvement in the reduction of unpleasant sensations was observed as early as 2 days after using micellar solution and increased over time. The use of this type of micellar solution, especially on sensitive skin, and the guidance of health professionals (dermatologists and pharmacists) may help to reduce the impact of unpleasant skin sensations.
Handling Matrix Calculations with Microservices within Scenarios of Modern Mobility

—In the context of modern mobility, topics such as smart-cities, Car2Car-Communication, extensive vehicle sensor-data, e-mobility and charging point management systems have to be considered. These topics of modern mobility often have in common that they are characterized by complex and extensive data situations. Vehicle position data, sensor data or vehicle communication data must be preprocessed, aggregated and analyzed. In many cases, the data is interdependent. For example, the vehicle position data of electric vehicles and surrounding charging points have a dependence on one another and characterize a competition situation between the vehicles. In the case of Car2Car-Communication, the positions of the vehicles must also be viewed in relation to each other. The data are dependent on each other and will inﬂuence the ability to establish a communication. This dependency can provoke very complex and large data situations, which can no longer be treated efﬁciently. With this work, a model is presented in order to be able to map such typical data situations with a strong dependency of the data among each other. Microservices can help reduce complexity.
Edinburgh Research Explorer The Birds and the Bees and the Flowers and the Trees: Lessons from Genetic Mapping of Sex Determination in Plants and Animals

The ability to identify genetic markers in nonmodel systems has allowed geneticists to construct linkage maps for a diversity of species, and the sex-determining locus is often among the ﬁrst to be mapped. Sex determination is an important area of study in developmental and evolutionary biology, as well as ecology. Its importance for organisms might suggest that sex determination is highly conserved. However, genetic studies have shown that sex determination mechanisms, and the genes involved, are surprisingly labile. We review studies using genetic mapping and phylogenetic inferences, which can help reveal evolutionary pattern within this lability and potentially identify the changes that have occurred among different sex determination systems. We deﬁne some of the terminology, particularly where confusion arises in writing about such a diverse range of organisms, and highlight some major differences between plants and animals, and some important similarities. We stress the importance of studying taxa suitable for testing hypotheses, and the need for phylogenetic studies directed to taxa where the patterns of changes can be most reliably inferred, if the ultimate goal of testing hypotheses regarding the selective forces that have led to changes in such an essential trait is to become feasible. region a new autosome. Translocations sex autosomes proto-sex chromosomes degenerated
Emotional labeling and attribute framing on pro-environmental product decision making

: Attribute framing effect refers to the fact that different descriptions of the same element can cause different reactions in people. This paper describes an experiment that was aimed at investigating attribute framing on pro-environmental product decision-making, having the consumer´s socially responsible behavior as a moderating effect. Framing effect was detected, but not as a universal response, since the type of evaluated product and the consumer´s level of socially responsible behavior can interfere in people´s judgements, by not producing the effect.
three adult escape

: Ambient air pollution is a leading environmental risk factor and its broad spectrum of adverse health e ﬀ ects includes a decrease in lung function. Socioeconomic status (SES) is known to be associated with both air pollution exposure and respiratory function. This study assesses the role of SES either as confounder or e ﬀ ect modiﬁer of the association between ambient air pollution and lung function. Cross-sectional data from three European multicenter adult cohorts were pooled to assess factors associated with lung function, including annual means of home outdoor NO 2 . Pre-bronchodilator lung function was measured according to the ATS-criteria. Multiple mixed linear models with random intercepts for study areas were used. Three di ﬀ erent factors (education, occupation and neighborhood unemployment rate) were considered to represent SES. NO 2 exposure was negatively associated with lung function. Occupation and neighborhood unemployment rates were not associated with lung function. However, the inclusion of the SES-variable education improved the models and the air pollution-lung function associations got slightly stronger. NO 2 associations with lung function were not substantially modiﬁed by SES-variables. In this multicenter European study we could show that SES plays a role as a confounder in the association of ambient NO 2 exposure with lung function.
NOTES AND CORRESPONDENCE Wave Over-reﬂection and Baroclinic Instability of the Eady Problem

The concept of wave over-reﬂection is applied to the unstable normal mode of the Eady problem. In order to consider propagation properties of the Rossby waves trapped at the boundaries, two thin boundary layers are introduced at the top and bottom of the ﬂuid layer of the original model. It is shown that the Rossby waves in the boundary layers are always over-reﬂected as long as their critical levels exist in the constant-shear evanescent region and the waves are transmitted to the opposite boundary layer. The dispersion relation obtained by using laser formula and quantization qualitatively coincides with that of the normal mode. Although the growth rate is systematically overestimated, the short-wave cutoff is well described by the over-reﬂection solution. The mechanism of over-reﬂection obtained in this study is understood by conservation of momentum. Since the pseudomomentum of the transmitted and the incident waves have opposite signs to each other, the amplitude of the reﬂected wave should become larger than that of the incident wave to satisfy constant momentum ﬂux constraints. This mechanism corresponds to that of over-reﬂection in a linear shear ﬂow of the shallow water model shown in a paper by Takehiro and Hayashi.
Long-Term Changes, Inter-Annual, and Monthly Variability of Sea Level at the Coasts of the Spanish Mediterranean and the Gulf of C á diz

: One of the effects of climate change is the rise of sea level, which poses an important threat to coastal areas. Therefore, the protection and management of coastal ecosystems as well as human infrastructures and constructions require an accurate knowledge of those changes occurring at a local scale. In this study, long time series of sea level from tide gauges distributed along the southern (Atlantic) and eastern (Mediterranean) Spanish coasts were analyzed. Linear trends were calculated for two periods, from early 1940s to 2018 and from 1990 to 2018. Values for the former period ranged between 0.68 and 1.22 mm/year. These trends experienced a signiﬁcant increase for the second period, when they ranged between 1.5 and 4.6 mm/year. Previous research analyzed the effect of atmospheric forcing in the Mediterranean Sea by means of 2D numerical models, and the steric contribution was directly evaluated by the integration of density along the water column. In this study, the effect of atmospheric forcing and the thermosteric and halosteric contributions on coastal sea level were empirically determined by means of statistical linear models that established which factors affected sea level at each location and what the numerical response of the observed sea level was to the contributing factors. Atmospheric pressure and the west–east component of the wind hada signiﬁcant contribution to the sea level variability at most of the tide gauges. The thermosteric and halosteric components of sea level also contributed to the sea level variability at all the tide gauges, with the only exception of Alicante. Atmospheric forcing and the steric components of sea level experienced long-term trends. The combination of such trends, with the response of sea level to these factors, allowed us to estimate their contribution to the observed sea level trends. The part of these trends not explained by the atmospheric variables and the steric contributions was attributed to mass addition. Trends associated with mass addition ranged between 0.6 and 1.2 mm/year for the period 1948–2018 and between 1.0 and 4.5 mm/year for the period 1990–2018.
Different Paciﬁc Ocean Warming Decaying Types and Northwest Paciﬁc Tropical Cyclone Activity

This study focuses on statistical analysis of anomalous tropical cyclone (TC) activities and the physical mechanisms behind these anomalies. Different patterns of decaying of the warm sea surface temperature anomaly (SSTA) over the equatorial central-eastern Paciﬁc are categorized into three types: eastern Paciﬁc warmingdecaying toLa Ni ~ na (EPWDL), easternPaciﬁcwarmingdecayingto a neutralphase(EPWDN),and a central Paciﬁc warming decaying year (CPWD). Differences in TC activity over the western North Paciﬁc (WNP) corresponding to the above three types are discussed, and possible mechanisms are proposed. For EPWDL, TC genesis shows a signiﬁcant positive (negative) anomaly over the northwestern (southeastern) WNP and more TCs move westward and make landfall over the southern East Asian coast. This is attributed primarily to the combined modulation of La Ni ~ na and the warm equatorial east Indian Ocean SSTA. For EPWDN,enhancedTC genesis is observedover the northeasternWNP,and suppressed TC activity is located mainly in the zonal region extending from the Philippine Sea to the eastern WNP, close to 160 8 E. Most of the TCs formed over the eastern WNP experience early recurvature east of 140 8 E, then move northeastward; hence, fewer TCs move northwestward to make landfall over the East Asian coast. For CPWD, the enhanced TC activity appears over the western WNP. This is due to the weak anomalous cyclonic circulation over the Philippines, primarily caused by the weaker, more westward-shifting warm SSTA compared to that
Macrophages in Mice Elimination of Porcine Hemopoietic Cells by

The difﬁculty in achieving donor hemopoietic engraftment across highly disparate xenogeneic species barriers poses a major obstacle to exploring xenograft tolerance induction by mixed chimerism. In this study, we observed that macrophages mediate strong rejection of porcine hemopoietic cells in mice. Depletion of macrophages with medronate-encapsulated liposomes (M-liposomes) markedly improved porcine chimerism, and early chimerism in particular, in sublethally irradiated immunodeﬁcient and lethally irradiated immunocompetent mice. Although porcine chimerism in the peripheral blood and spleen of M-liposome-treated mice rapidly declined after macrophages had recovered and became indistinguishable from controls by wk 5 post-trans-plant, the levels of chimerism in the marrow of these mice remained higher than those in control recipients at 8 wks after transplant. These results suggest that macrophages that developed in the presence of porcine chimerism were not adapted to the porcine donor and that marrow-resident macrophages did not phagocytose porcine cells. Moreover, M-liposome treatment had no effect on the survival of porcine PBMC injected into the recipient peritoneal cavity, but was essential for the migration and relocation of these cells into other tissues/organs, such as spleen, bone marrow, and peripheral blood. Together, our results suggest that murine reticuloendothelial macrophages, but not those in the bone marrow and peritoneal cavity, play a signiﬁcant role in the clearance of porcine hemopoietic cells in vivo. Because injection of M-liposomes i.v. mainly depletes splenic macrophages and liver Kupffer cells, the spleen and/or liver are likely the primary sites of porcine cell clearance in vivo.
Impact of Oxidized Low Density Lipoprotein on Cytokine Production and Immune Dialogue between Mononuclears and Colon Carcinoma Cells

Background: Cholesterol is carried out to the cells via Low (LDL) - and High (HDL) Density Lipoproteins. In its oxidized state (Ox-LDL) it possesses immunomodulatory properties and is capable to promote carcinogenesis. The aim of the study was to examine its effect on the proliferation of human Peripheral Blood Mononuclear Cells (PBMC) and cells from two colon carcinoma cell lines. Cytokine production by PBMC incubated without and with cancer cells in the presence of Ox-LDL was evaluated. Methods: PBMC were incubated with 1µg/ml, 2µg/ml and 5µg/ml Ox- LDL and the secretion of TNFα, IL-1β, IL-2, IL-6, IL-10, IL-1ra and IFNγ was evaluated. The production of cytokines by PBMC stimulated with cells from HT- 29 or HuCC lines was detected upon the effect of various doses of Ox-LDL. Results: Ox-LDL stimulated the proliferation of PBMC and HuCC cells but not on that of HT-29. Ox-LDL increased the production of IL-6, IFNγ and IL-10 by non-stimulated PBMC and that of TNFα, IL-1β and IFNγ by mitogen stimulated cells. Ox-LDL added to co-cultures of PBMC and HT-29 cells inhibited all cytokines, except for IL-2 that augmented with the highest concentration of Ox- LDL. PBMC incubated with HuCC cells in the presence of Ox-LDL produced decreased production of TNFα, while the secretion of the remaining cytokines was not affected. Conclusions: Ox-LDL promotes PBMC to produce a part of the cytokines hereby examined. The inhibited secretion of all cytokines by PBMC incubated with HT-29 cells in the presence of Ox-LDL may clarify the immunomodulatory role of Ox-LDL in carcinogenesis.
Ordered-subset simultaneous algebraic reconstruction techniques (OS-SART)

In this paper, we propose two ordered-subset simultaneous algebraic reconstruction techniques (OS-SART). First, we describe the heuristics in support of the two OS-SART formulas. Then, we study the convergence in the framework of our recent work on the OS version of the Landweber scheme. It is shown that our first OS-SART is a special case of the OS version of the Landweber scheme. Hence, it converges in the weighted least square sense even in the case of inconsistent data. Both the OS-SART formulas are tested for reconstruction of CT images from practical data.
'The Mould that Changed the World'

Background A primary school musical (“The Mould that Changed the World”) was developed as a unique public engagement strategy to combat antimicrobial resistance (AMR) by engaging children in the story of the discovery of antibiotics, the risks of drug-resistant infections and the importance of prudent antibiotic use. The musical intervention was implemented in two UK primary schools by music specialists through a series of workshops, associated learning resources and performances to rela-tives. Participating children (n = 182), aged 9 to 11 years, were given an online questionnaire in the classroom before rehearsals began and at two weeks post-performance with a six-month evaluation in one school. The impact of the musical was analysed using generalised linear models to control for confounding factors. For the qualitative evaluation, fifteen participating children were selected randomly from each school to take part in semi-structured focus groups (n = 5 per group) before rehearsals began and two weeks post-performance. key the post- 88%, n = (bac-teria
Title: Is the combination of MR and CT findings useful in determining the tumor grade of pancreatic neuroendocrine tumors?

Purpose: To retrospectively elucidate the findings useful in determining the tumor grade of pancreatic neuroendocrine tumors (PNETs) by combined assessment of magnetic resonance (MR) and dynamic computed tomography (CT) images. Materials and methods: Eighty-nine patients with PNETs (96 lesions) were included, and classified as G1, 59; G2, 29; and G3, 8 lesions. Image analysis included lesion diameter, shape, enhancement pattern on arterial phase (AP) and delayed phase CT images, calcification, cystic portion, main pancreatic duct dilatation, signal-intensity on T1-, T2-weighted MR images, and appearance of apparent diffusion coefficient (ADC). Results: Significant differences among G1, G2, and G3 groups were noted in tumor maximal diameter ( p <0.0001), shape ( p <0.0001), enhancement pattern on AP image ( p <0.0001), cystic portion ( p =0.012), and ADC finding. In multivariate analysis, ADC finding was the independent factor ( p =0.002). The combination findings of low ADC ratio (ADC value of the lesion/ADC value of the parenchyma <0.94), not homogeneous hyper-attenuation, lobulated shape, and hyper-intensity on T2-weighted image were suggestive of G2 or G3 with a probability of 100%. Conversely, all lesions with high ADC ratio and small size ( ≤ 25mm) belonged to G1 group. Conclusion: Combined assessment of MR and CT findings could improve the prediction of tumor grading in PNETs. PNETs the of the histologic findings of hematoxylin-eosin staining, and immunohistochemical expression of chromogranin A and synaptophysin. tumor counting the number of mitoses per 10 high-power-fields, evaluating the Ki-67 proliferation index. Evaluation of the Ki-67 index performed using immunohistochemistry with MIB-1 antibody at the level of the maximal diameter of the tumor. All collected to our institution and re-evaluated by a single pancreatic pathologist with 14-years’ experience. In the histopathologic analysis of 96 PNETs, 59 lesions (61.5 were classified as G1; 29 (30.2 %), as G2; and 8 (8.3 %), as G3.
The Presupernova H II Region around SN 1987A

The slow expansion of the bright ring around SN 1987A and the large size estimated for the radio source at an age of ~1500 days suggest a low mass-loss rate, Ṁ, from the blue supergiant progenitor star; we adopt Ṁ = 7.5 × 10-8 M☉ yr-1 and a wind velocity vw = 450 km s-1 as standard values. This wind density would not give substantial radio free-free absorption during the first few days when low-frequency absorption was observed, but the turnover can be attributed to synchrotron self-absorption. The X-ray and radio emission observed since 1990 require that the supernova shock be interacting with denser gas than that in the free wind. We propose that it is interacting with an H II region created by the B3 Ia progenitor star in the swept-up red supergiant wind. The H II region extends from a radius rII ≈ 3 × 1017 cm to the ring radius R = 6 × 1017 cm in the equatorial plane and has a hydrogen density ~102 cm-3. The shock front will not reach the dense ring until the year 2005 ± 3. The X-ray luminosity should slowly increase until that time. The equatorial ionization front is trapped in the swept-up gas; the dense ring and its associated bipolar nebula are the initially neutral part of the shell. In the polar direction, the ionization front broke out of the swept-up gas, and there is no dense neutral shell, consistent with the observed lack of a thin shell in that direction.
COPD_A_297980 1021..1033

1Complejo Hospitalario Universitario de Pontevedra, Pontevedra, Spain; 2Hospital Universitario de Getafe, Madrid, Spain; 3Hospital Unvidersitario Son Llàtzer, Palma de Mallorca, Spain; 4Hospital Comarcal de Laredo, Cantabria, Spain; 5Hospital Universitario de la Plana, Castellón, Spain; 6Hospital Virgen del Rocío, Sevilla, Spain; 7CIBERES, Instituto de Salud Carlos III, Madrid, Spain; 8Hospital de Sagunto, Valencia, Spain; 9Hospital Universitario Clínic, Barcelona, Spain; 10Hospital Universitario Virgen de la Victoria, Málaga, Spain; 11Pulmonology Section, Hospital Universitario del Tajo, Aranjuez, Spain Background: Our aim was to describe: 1) lung deposition and inspiratory flow rate; 2) main characteristics of inhaler devices in chronic obstructive pulmonary disease (COPD). Methods: A systematic literature review (SLR) was conducted to analyze the features and results of inhaler devices in COPD patients. These devices included pressurized metereddose inhalers (pMDIs), dry powder inhalers (DPIs), and a soft mist inhaler (SMI). Inclusion and exclusion criteria were established, as well as search strategies (Medline, Embase, and the Cochrane Library up to April 2019). In vitro and in vivo studies were included. Two reviewers selected articles, collected and analyzed data independently. Narrative searches complemented the SLR. We discussed the results of the reviews in a nominal group meeting and agreed on various general principles and recommendations. Results: The SLR included 71 articles, some were of low–moderate quality, and there was great variability regarding populations and outcomes. Lung deposition rates varied across devices: 8%–53% for pMDIs, 7%-69% for DPIs, and 39%–67% for the SMI. The aerosol exit velocity was high with pMDIs (more than 3 m/s), while it is much slower (0.84–0.72 m/ s) with the SMI. In general, pMDIs produce large-sized particles (1.22–8 μm), DPIs produce medium-sized particles (1.8–4.8 μm), and 60% of the particles reach an aerodynamic diameter <5 μm with the SMI. All inhalation devices reach central and peripheral lung regions, but the SMI distribution pattern might be better compared with pMDIs. DPIs’ intrinsic resistance is higher than that of pMDIs and SMI, which are relatively similar and low. Depending on the DPI, the minimum flow inspiratory rate required was 30 L/min. pMDIs and SMI did not require a high inspiratory flow rate. Conclusion: Lung deposition and inspiratory flow rate are key factors when selecting an inhalation device in COPD patients.