Miracle-dz/UniFAR-FTUs huggingface dataset:
Update on Febrile Neutropenia in Pediatric Oncological Patients Undergoing Chemotherapy

Febrile neutropenia (FN) is a common complication of chemotherapy in oncological children and one of the most important causes of morbidity and mortality in these patients. The early detection of a bacteremia and the rapid therapeutic intervention are crucial to improve the outcome. We analyzed the literature in order to clarify the epidemiology of FN in children undergoing chemotherapy, the specific factors associated with a negative outcome, the most common etiology, and the value of biological markers as a tool to make an early diagnosis or to monitor the evolution of the infection. Several studies have tried to identify specific factors that could help the clinician in the detection of an infection and in its microbiological identification. However, due to the heterogenicity of the available studies, sufficient evidence is lacking to establish the role of these risk factors in clinical practice and future research on this topic appear mandatory. Determinations of risk factors, etiology, and markers of febrile episodes in these patients are complicated by the characteristics of the underlying illness and the effects of treatments received. Although some studies have tried to develop an evidence-based guideline for the empiric management of FN in pediatrics, validated predictive scores and algorithms are still lacking and urgently needed.
NONLINEAR ANALYSIS OF INTEGRAL ABUTMENT BRIDGES

A state-of-the-art, three-dimensional, nonlinear finite element algorithm is developed and used to study piling stresses and pile-soil interaction in integral abutment bridges. The finite element idealization consists of beam-column elements with geometric and material nonlinearities for the pile, and nonlinear springs for the soil. An idealized soil model (a modified Ramberg-Osgood cyclic model) was introduced in this investigation to obtain the tangent stiffness of the nonlinear spring elements. Several numerical examples, including results on an existing bridge, are presented. The finite element model and the computer software developed are found to give reliable methods.
Testing the robustness of the job demands-resources model.

According to the job demands–resources (JD–R) model, job demands and resources evoke two relatively independent processes: health impairment and employee motivation. The robustness of the JD–R model was tested in two different occupational samples, the first of 654 Spanish employees and the second of 477 Dutch employees. Structural equation modeling analyses provided partial evidence for the two processes. Multigroup analyses showed that the structural paths of the model were invariant across countries, although the strength of the relationships differed. We conclude that the basic structure of the JD–R model is maintained, even when applied in different national and occupational contexts, when using different ways of gathering data (computerized versus paper and pencil), and when using slightly different measures to assess the key variables of the model.
Optimized 3D Culture of Hepatic Cells for Liver Organoid Metabolic Assays

The liver is among the principal organs for glucose homeostasis and metabolism. Studies of liver metabolism are limited by the inability to expand primary hepatocytes in vitro while maintaining their metabolic functions. Human hepatic three-dimensional (3D) organoids have been established using defined factors, yet hepatic organoids from adult donors showed impaired expansion. We examined conditions to facilitate the expansion of adult donor-derived hepatic organoids (HepAOs) and HepG2 cells in organoid cultures (HepGOs) using combinations of growth factors and small molecules. The expansion dynamics, gluconeogenic and HNF4α expression, and albumin secretion are assessed. The conditions tested allow the generation of HepAOs and HepGOs in 3D cultures. Nevertheless, gluconeogenic gene expression varies greatly between conditions. The organoid expansion rates are limited when including the TGFβ inhibitor A8301, while are relatively higher with Forskolin (FSK) and Oncostatin M (OSM). Notably, expanded HepGOs grown in the optimized condition maintain detectable gluconeogenic expression in a spatiotemporal distribution at 8 weeks. We present optimized conditions by limiting A8301 and incorporating FSK and OSM to allow the expansion of HepAOs from adult donors and HepGOs with gluconeogenic competence. These models increase the repertoire of human hepatic cellular tools available for use in liver metabolic assays.
Factors Related to the Risk of Occupational Stress among Nurses in the Emergency Room at Sosodoro Djatikoesoemo Bojonegoro Hospital

Introduction: Occupational stress is a body response that is present in the form of physiological, psychological, and behavioral responses to stressors in the work environment. If this condition is not handled properly, it will have a negative impact on workers, and it can reduce the level of health and cause several diseases. The purpose of this research was to determine the risk of occupational stress among nurses in the Emergency Room at Sosodoro Djatikoesoemodan Hospital and what factors were related to the risk of occupational stress. Methods: This research is a descriptive observational study with respondents consisting of 26 nurses in the Emergency Room at Sosodoro Djatikoesoemo Hospital. Data collection was done using questionnaires to measure the level of occupational stress risk of nurses, which included variables of individual worker’s characteristics and job characteristics. The data analysis in this study used the Spearman correlation. Results: The results showed that 15.4% of nurses had a low level of occupational stress risk, 69.2% had a moderate level of occupational stress risk, and 15.4% had a high level of occupational stress risk. Moreover, there was a significant relationship between social support and workload factors on the risk of occupational stress. Conclusion: Most of the nurses experienced moderate occupational stress. Gender, personality type, workload and mental demands were factors that were related to the risk of occupational stress and could increase the risk of occupational stress. Meanwhile, interpersonal conflict and job control were elements that were not related to the risk of occupational stress.Keywords: emergency room Sododoro Djatikoesomo hospital, nurses, risk of occupational stress
RURAL WATER SUPPLY PROJECTS AND SUSTAINABLE DEVELOPMENT IN NIGERIA

The study reviews the sustainability issues that are associated with rural community water provision and some of the challenges experienced in the in Niger Delta region of Nigeria within the context of project benefits sustenance. Several rural communities in Nigeria derive water supply through hand pump operated water supply wells. The sustainability of this approach to water provision was assessed using a qualitative research methodology and undertaking a comparative review of Micro-Projects Programme (MPP3) in Nigeria with that of Volta Region Community Water Supply Programme (VRCWSP), in Ghana. The findings reveal the absence of sustainability in the current approach and the paper recommends that if community based hand pump operated rural water supply projects are to be sustainable; the sustainability factors must be given full consideration in its design and implementation. A post-project management approach is suggested which should be effectively monitored, assessed, linked and integrated into the implementation and post-operational management of hand pumps water supply systems. The use of a community based and community driven project-management options in the management of community rural water supply is proposed as this remains a credible alternative over control by external or government agencies.
Output‐feedback finite‐time and exponential tracking continuous control for mechanical systems with constrained inputs

An output‐feedback finite‐time/exponential tracking continuous control scheme for mechanical systems with constrained inputs is proposed. The developed controller has a velocity‐free saturating‐proportional saturating‐derivative type structure, inducing damping through a dirty‐derivative based auxiliary dynamics. Special well‐defined functions that coat the error correction actions of the control scheme give the required shaping for the concerned type of convergence and input saturation avoidance. The type of convergence is determined through the choice on the values of specific control parameters. Differently to similar previous approaches for state‐feedback tracking or output‐feedback regulation, the control parameters that determine the trajectory convergence are not restricted to satisfy a fixed equivalence relation but rather a wider comparative one. This expands the spectrum of finite‐time convergent trajectories that may be induced, and further gives the option of an additional (unconventional) type of exponential stability (in addition to the conventional one). The closed‐loop analysis is supported through suitable strict Lyapunov functions. Experimental tests on a 3‐degree‐of‐freedom robot manipulator further support the contributed result.
SELECTING LCMS IN HIGHER EDUCATION: LESSONS FROM THE SOUTH AFRICAN MINING INDUSTRY

The Learning Content Management System (LCMS) plays an important role in the integration of online learning. The purpose of the study on which this paper is based was thus to investigate how the South African corporate organisations select their LCMSs. This study involved 15 South African organisations from various industrial sectors. However, this paper reflects experiences of the three mining organisations (mining industry) only. This paper will reflect procedures that could be followed when selecting the LCMS. These procedures are lessons that were from the South African mining industry. It is the belief of the authors that the higher education institutions could learn from these lessons.
Mechanisms of Neuronal Damage in Acute Hepatic Porphyrias

Porphyrias are a group of congenital and acquired diseases caused by an enzymatic impairment in the biosynthesis of heme. Depending on the specific enzyme involved, different types of porphyrias (i.e., chronic vs. acute, cutaneous vs. neurovisceral, hepatic vs. erythropoietic) are described, with different clinical presentations. Acute hepatic porphyrias (AHPs) are characterized by life-threatening acute neuro-visceral crises (acute porphyric attacks, APAs), featuring a wide range of neuropathic (central, peripheral, autonomic) manifestations. APAs are usually unleashed by external “porphyrinogenic” triggers, which are thought to cause an increased metabolic demand for heme. During APAs, the heme precursors δ-aminolevulinic acid (ALA) and porphobilinogen (PBG) accumulate in the bloodstream and urine. Even though several hypotheses have been developed to explain the protean clinical picture of APAs, the exact mechanism of neuronal damage in AHPs is still a matter of debate. In recent decades, a role has been proposed for oxidative damage caused by ALA, mitochondrial and synaptic ALA toxicity, dysfunction induced by relative heme deficiency on cytochromes and other hemeproteins (i.e., nitric oxide synthases), pyridoxal phosphate functional deficiency, derangements in the metabolic pathways of tryptophan, and other factors. Since the pathway leading to the biosynthesis of heme is inscribed into a complex network of interactions, which also includes some fundamental processes of basal metabolism, a disruption in any of the steps of this pathway is likely to have multiple pathogenic effects. Here, we aim to provide a comprehensive review of the current evidence regarding the mechanisms of neuronal damage in AHPs.
Examining Gaze Cone Shape and Size

Another person's looking behavior is used by observers to judge gaze direction and fixation points. An important task in this context is the judgement of direct gaze, that is, the perception of being looked at. The cone of gaze can be defined as the range of fixation points that support direct gaze. The cone concept implies that this range lawfully increases with distance, but that the cone angle is constant. The present experiment tested the concept with a larger number and a more extended range of distances than previously done, and took care of possible directional errors. The gaze cone was found to be roughly linear, and stable between 1.6 m and 7.9 m – an almost perfect cone. The mean cone size subtended 5.2° in diameter when averaged over ascending and descending series. Measures differed, however, in ascending and descending series, consistent with a conservative bias. Also, the variability of judgements increased slightly with distance. Results are discussed considering whether cone size is actually smaller than often reported in the literature.
On the Design of Pulse Peak Stretchers

This paper deals with the design of feedback peak stretchers, its main aim being that of ensuring both linearity and absolute accuracy as well as a fairly low degree of sensitivity to the input shape. A preliminary discussion on the limitations of the blocks which constitute the feedback loop of the stretcher is followed by suggestions for their realization. The conclusion of a short theoretical analysis are summarized, for an easier choice of the proper solution according to the various applications. Finally, different schemes of stretchers are given, which are believed to satisfy most of practical needs, and the results of the experimental tests are shown.
Patient perceptions of allied health student communication and interpersonal skills: A cross-sectional study

Introduction: Effective patient–practitioner communication contributes to patient health outcomes by strengthening therapeutic relationships and, in the process, contributing to overall quality of patient care. Despite the growth of student-led university teaching clinics, little research has investigated communication skills within this context. Therefore, the aim of this study was to investigate the patient-perceived levels of communication and interpersonal skills within a student-led allied health clinic.Methods: The Communication Assessment Tool (CAT) was used to collect cross-sectional data on patients’ perceptions of student communication and interpersonal skills within an osteopathy teaching clinic. Data were analysed via descriptive and inferential statistics.Results: According to the CAT, patients perceived the students’ communication and interpersonal skills to be “excellent” overall (97.2%). No significant differences were found between percentage of “excellent” responses and gender (p = .600), number of consultations (p = .374) or pain duration (p = .741). Conclusions: Patients in this setting perceive student communication and interpersonal skills to be of a high standard. This can contribute positively to the patient–practitioner therapeutic alliance and may improve overall health outcomes. These findings have implications for communication training within student-led health professions clinics and tertiary curricula more broadly.
Reproductive and Productive Performance of APRI Primiparous Rabbit Does Influenced by Copper Sources During Pregnancy Period

| The present study aimed particularly to study the impact of different dietary copper forms on new synthetic APRI line under Egyptian conditions. Forty primiparous APRI rabbit does aged between 5-6 months were divided into 4 equal groups; the first group was considered as control one (G1) that fed with basal diet; G2 is the second group fed basal diet supplemented with Nano-Cu particles (50mg/kg diet). The G3 and G4 are groups that supplemented with 200 mg /kg of Cu-SO4 (metal copper) and 200 mg / kg of copper-methionine (organic source), respectively. The results showed that, level of estrogen was higher (P<0.05) in treated groups (especially G2) than that in G1. In addition, the supplemented copper forms exhibited positive impact (P<0.05) on rabbit does body weight, starting from one month before insemination reaching to kits weaning age. The conception rate was higher in treated groups than that in G1 by 50%, 33% and 16.6%, in groups G2, G3 and G4 respectively. They born bunny with body weight at birth, 41.42 g, 33.63 g, 36.13 g and 45.71g in G1, G2, G3 and G4 respectively. Moreover higher (P<0.05) litter size at birth was recorded in G2 in comparison with control group and other treated groups. Additionally the supplemented Cu resulted in producing kits with higher (P<0.05) body weight (especially G2) than G1. Milk production was affected (P<0.05) by Cu supplementation and recorded as 150.5, 173.0, 208.0 and 212.5 g/day/doe, in G1, G2, G3 and G4, respectively at 3rd week of lactation. Milk protein, and fat percentages were also modulated (P<0.05) by the Cu treatment. In conclusion, supplemented rabbit does with different copper forms enhanced does and kits performance, especially the group supplemented with Nano-Cu.
The modelling and fabrication of widely tunable capacitors

Coventorware 2001.1® has been used to model a widely tunable, two-gap capacitor structure. This paper explores the use of the Coventorware® to achieve a design specification and confirms device operation. Tunable capacitors fabricated to this specification have achieved a tuning ratio of 5.1:1, the best reported to date.
Obstetric Complications and Polygenic Risk Score: Which Role in Predicting a Severe Short-Term Outcome in Psychosis?

Understanding and improving the outcomes of psychosis remains a major challenge for clinical research. Obstetric complications (OCs) as a risk factor for schizophrenia (SZ) have been investigated as a potential predictor of outcomes in relation to illness severity and poorer treatment outcome, but there are less reports on first episode psychosis (FEP) patients. We test whether OCs, collected in a cohort of FEP patients, can predict illness course and psychopathology severity after 2 years from the onset. Moreover, we explore whether the SZ-polygenic risk score (PRS) would predict the illness course and whether the interaction between OCS and PRS shows a significant effect. A cohort of 264 FEP patients were assessed with standardized instruments. OCs were recorded using the Lewis–Murray scale in interviews with the patients’ mothers: 30% of them reported at least one OC. Patients with at least one OC were more likely to have a non-remitting course of illness compared to those without OCs (35.3% vs. 16.3%, p = 0.014). No association between SZ-PRS and course of illness nor evidence for a gene–environment interaction was found. In our sample, poor short-term outcomes were associated with OCs, while SZ-PRS was not a prognostic indicator of poor outcomes.
OPTIMISATION OF BEARING DIAGNOSTIC TECHNIQUES USING SIMULATED AND ACTUAL BEARING FAULT SIGNALS

Abstract In this paper, bearing fault vibrations are modelled as a series of impulse responses of a single-degree-of-freedom system. The model incorporates slight random variations in the time between pulses so as to resemble actual vibration signals. Although the bearing fault harmonics in the raw spectrum are caused by the random fluctuations to smear over one another, they remain quite clear in the spectrum of the envelope. However, the envelope spectrum is still prone to masking by discrete and random noise. Therefore, the simulated bearing fault signals were used to investigate the efficient application of self-adaptive noise cancellation (SANC) in conjunction with envelope analysis in order to remove discrete frequency masking signals. Two ways of combining these techniques have been suggested, both of which require the original signal to be band-pass filtered and frequency-shifted in order to reduce the number of samples to be processed by SANC. The subsequent envelope analysis can then be performed by using the Hilbert transform technique or band-pass rectification. Band-pass rectification is simpler but requires extra zero padding above and below the demodulation band, making the length of the signal processed by SANC twice as long as with the former method, but still only a fraction of the length of the original signal. On the other hand, the Hilbert technique requires an extra forward and inverse discrete Fourier transform operation compared with band-pass rectification. These two methods reduce the masking effects in the envelope spectrum by removing pseudo-sum frequencies or placing them outside the frequency range of interest. This is illustrated with examples of simulated and actual vibration signals. The removal of discrete frequency noise using SANC is also demonstrated for actual vibration signals. The threshold for which analysing the squared envelope or its higher powers gives an improvement in the envelope spectrum has also been defined using simulated and actual vibration signals. The treatment in the paper is qualitative and non-mathematical for purposes of clarity, but reference is made to a quantitative treatment of the effects of masking.
W-gated trench power MOSFET (WFET)

A W-shaped-gate power trench MOSFET (WFET) that demonstrates a significant reduction in gate-drain charge Q/sub gd/, a low on-resistance and good production process margin is presented. The gate is formed using a thicker oxide, self-aligned to the P-body/N-epi junction at the bottom of the trench. Fabricated 35 V N-channel devices exhibit a r/sub DS(on)/*Q/sub gd/ figure of merit of 12.5 m/spl Omega/. nC with V/sub GS/=10 V and V/sub DD/=15 V. Experimental data of devices fabricated using LOCOS and sub-atmospheric CVD (SACVD) processes to form the thicker oxide layer are reported along with simulation results.
Comparison of measured rain attenuation and ITU-R predictions on experimental microwave links in Malaysia

This paper presents the results of direct rain attenuation measurements carried out on four experimental microwave links, installed at UTM, Malaysia. The links operate at frequencies of 15, 22, 26, and 38 GHz and the cumulative distribution function for different rain rates have been generated from the measured 4-year rain gauge data. The experimentally measured attenuation data have been compared with International Telecommunication Unior-R rain attenuation predictions; and it has been found that the latter have underestimated the measured values, especially at higher rain rates. The deviations have been modeled as a function of rain rate exceedances R%p. It is hoped that the study will provide useful information for estimation of rainfall attenuation on microwave links in tropical regions that have similar situation to Malaysia.
Influence of sucrosis on the degradation of pesticide by white rot fungus

The influence of sucrose on the removal of Paraquat (PQT) in synthetic aqueous medium was evaluated by Phanerochaete chrysosporium. Initially, a toxicity test was performed on plates containing paraquat at concentrations of 1, 5, 10, 20 and 30 mg.L-1. Then, they were carried out in batches - agitated batch (RBA) and sequential batch (RBS). Four reactors were submitted, containing medium with 30 mg.L-1 of paraquat, under a reaction time of 144 h, the reactors being RBA-2 and RBS-2 with the addition of 2 gL-1 of sucrose, and without the adding sucrose to the RBA-0 and RBS-0 reactors. In all reactors, paraquat was removed, but in RBS-0, the best mean removal efficiency was obtained (41.1 ± 0.89%). The best values ​​of apparent speed of degradation (k) were found in reactors with sucrose RBA-2 and RBS-2, 0.015 ± 0.002 h-1 and 0.018 ± 0.002 h-1, respectively, indicating that the addition of sucrose influenced the speed removal of paraquat. It was also verified that the pollutant was not completely removed by adsorption to fungal biomass, which microorganisms predominated in the medium at the end of the treatment, demonstrating their role in the paraquat bioremediation process. Therefore, the addition of sucrose influenced the removal speed of the PQT and COD, but not the removal efficiency.