Miracle-dz/UniFAR-FTUs huggingface dataset:
A clinical and epidemiological study on discoid lupus erythematosus

<p class="abstract"><strong>Background:</strong> Discoid lupus erythematosus (DLE) is the commonest form of cutaneous lupus erythematosus.The objective of our study is to analyze the clinical and epidemiological aspects of DLE. </p><p class="abstract"><strong>Methods:</strong> All clinically diagnosed cases of DLE attending the dermatology OPD from October 2010 to September 2012were included in the study. A detailed history, complete physical examination, biopsy for confirmation and other relevant investigations were done in all cases. <strong></strong></p><p class="abstract"><strong>Results:</strong> The incidence was 4.79 per 10000 cases (51 of 106368 dermatology patients) showing female to male ratio of 4.1:1. Localized type was more common than the disseminated type. Few lesions (less than five) in a localized area without head and neck involvement were also classified as localized type in this study. Mucosal, verrucous, tumid and lupus panniculitis were the variants of DLE encountered. The sites involved were face, scalp, trunk, upper and lower limb in descending order of frequency. Antinuclear antibody (ANA) was positive in 22 of 30 cases done (73%). The systemic involvement was seen in 15 patients all of whom were diagnosed as systemic lupus erythematosus (SLE). Squamous cell carcinoma was seen in 2 cases of disseminated DLE. </p><p class="abstract"><strong>Conclusions:</strong> Majority of patients had disease onset at 3<sup>rd</sup> to 5<sup>th</sup> decade showing female predominance. When compared to localized type, disseminated type was found more frequently in males. Early onset and severe disease was noted among offspring born to a patient suffering from disseminated DLE. Serious morbidity like lupus nephritis was observed only in 1 case. The occurrence of DLE over the herpes zoster scar was an interesting observation. </p>
Should We Eat Meat?: Evolution and Consequences of Modern Carnivory

Publish By John Wiley & Sons | PDF Free Download OR READ ONLINE 2013-03-18. Online Ebook, Should We Eat Meat? Evolution and Consequences of Modern Carnivory PDF Read ePub Online ;Download : A Novel Ebooks Free, Days Should We Eat Meat? Evolution and Consequences of Modern Carnivory: A Novel PDF PDF Read ePub Should We Eat Meat? Evolution and Consequences of Modern Carnivory: A Novel Popular Download Should We Eat Meat? Evolution and Consequences of Modern Carnivory: PDF Read ePub A Novel Read DownloadShould We Eat Meat? Evolution and Consequences of Modern Carnivory: Should We Eat Meat? Evolution and Consequences of Modern Carnivory Free On PDF | REad Online FUll Free>> Should We Eat Meat? Evolution and Consequences of Modern Carnivory by Vaclav Smil Read Online; PDF EPUB FREE DOWNLAOD } Meat eating is often a contentious subject, whether considering the technical, ethical, environmental, political, or health-related aspects of production and consumption. This book is a wide-ranging and interdisciplinary examination and critique of meat consumption by humans, throughout their evolution and around the world. Setting the scene with a chapter on meat’s role in human evolution and its growing influence during the development of agricultural practices, the book goes on to examine modern production systems, their efficiencies, outputs, and impacts.
A Pentavalent Epstein-Barr Virus-Like Particle Vaccine Elicits High Titers of Neutralizing Antibodies against Epstein-Barr Virus Infection in Immunized Rabbits

Primary infection with Epstein-Barr virus (EBV) is associated with acute infectious mononucleosis, whereas persistent infection is associated with chronic diseases such as autoimmune diseases and various types of cancer. Indeed, approximately 2% of all new cancer cases occurring annually worldwide are EBV-associated. Currently, there is no licensed EBV prophylactic vaccine. Selection of appropriate viral protein subunits is critical for development of an effective vaccine. Although the major EBV surface glycoprotein gp350/220 (gp350) has been proposed as an important prophylactic vaccine target, attempts to develop a potent vaccine based on gp350 alone have shown limited success in the clinic. We provide data showing that five EBV glycoproteins (gp350, gB, gp42, gH, and gL) involved in viral entry and infection can successfully be incorporated on the surface of EBV-like particles (EBV-LPs). These EBV-LPs, when administered together with aluminum hydroxide and monophosphoryl lipid A as adjuvants to New Zealand white rabbits, elicited EBV glycoprotein-specific antibodies capable of neutralizing viral infection in vitro in both B cells and epithelial cells, better than soluble gp350 ectodomain. Our findings suggest that a pentavalent EBV-LP formulation might be an ideal candidate for development as a safe and immunogenic EBV vaccine.
Prevalence of Catheter-associated bacteriuria in patients who received short-term catheterization in the northeast of Iran

Background: Catheter-associated (CA) bacteriuria is a result of the extensive usage of urinary catheterization. Once a catheter is placed, many patients achieve bacteriuria, even with the use of greatest consideration and care of the catheter. In this study, we decided to evaluate the prevalence of Catheter-associated bacteriuria in patients who received short-term catheterization in the northeast of Iran. M aterials and Methods: In this cross-sectional study during one year (among 2014-2015) 275 patients who have admitted recently and have no history of catheterization and drug consumption were included. Three samples were taken from patients before, one day after catheterization and after removal of the catheter. The urine samples were analyzed and cultured on the suitable media. Antibiotics susceptibility testing was performed by disk diffusion method. Then, data analyzed using SPSS software by Student t-test. In addition, the p values less than 0.05 were considered as significant. R es ults: In general, the rate of catheter-associated bacteriuria in these hospitals was 68% (187 cases of 275). The mean age of the participants and patients with bacteriuria were 41±1.2 and 24.8±6.2 years old, respectively. The most common isolated bacteria were Escherichia coli (50.6%) followed by Staphylococcus aureus and Klebsiella pneumonia (21.6%). The highest sensitivity was reported against kanamycin (68.9%) and highest resistance was observed against ampicillin with a rate of 96.3%. C onclusion: For prevention of healthcare-associated UTI, correct catheterization and use of the closed catheter system is recommended. In addition, before prescribing any antibiotics it should be paying attention to the antibiotics susceptibility testing results.
Muscle Activity During a Single Set of Resistance Training to Failure in Women With Chronic Neck and Shoulder Pain Before and After 10 Weeks Training

Background: Resistance training to failure is an advanced method often used by healthy individuals. Little is known about this type of training in individuals with musculoskeletal pain. Purpose: This study investigates the effect of 10 weeks’ elastic resistance training on neck and shoulder muscle activity during a single set to failure. Study design: This was an observational cohort study. Methods: Sixteen untrained, female office workers with chronic neck and shoulder pain performed 10 weeks of elastic resistance exercise as a single set of lateral raise to failure during workdays. Electromyography (EMG) amplitude and median power frequency (MPF) from the splenius and the upper trapezius muscles were analyzed. Results: EMG amplitude increased and MPF decreased linearly from the first to the last repetition during the set, before and after the 10 weeks of training. For the first few repetitions of exercise, muscle activity was higher after 10 weeks than before the intervention (91% vs.74%, P = 0.03). However, during the last repetitions, similar high levels of EMG amplitude were noted both before and after the 10 weeks (129% vs.127%, P = 0.81). The MPF before and after the training intervention was 79 and 77 Hz (P = 0.69), respectively, during the first repetitions, and 66 and 69 Hz (P = 0.62) during the last repetitions of exercise. The increase in EMG and decrease in MPF – which were similar before and after 10 weeks – are good indicators of acute muscle fatigue. Conclusion: The results indicate that untrained women with neck-shoulder pain are capable of training to failure, and concur with previous results showing rapid benefits in terms of muscle strength and pain reductions from this type of training.
Does recombinant human erythropoietin administration in critically ill COVID‐19 patients have miraculous therapeutic effects?

An 80‐year‐old man with multiple comorbidities presented to the emergency department with tachypnea, tachycardia, fever, and critically low O2 saturation and definitive chest computerized tomography scan findings in favor of COVID‐19 and positive PCR results in 48 hours. He received antiviral treatment plus recombinant human erythropoietin (rhEPO) due to his severe anemia. After 7 days of treatment, he was discharged with miraculous improvement in his symptoms and hemoglobin level. We concluded that rhEPO could attenuate respiratory distress syndrome and confront the severe acute respiratory syndrome coronavirus 2 virus through multiple mechanisms including cytokine modulation, antiapoptotic effects, leukocyte release from bone marrow, and iron redistribution away from the intracellular virus.
Poor use of postnatal care service at health facilities in rural Southern Benin: What factors should we target?

Postnatal consultation helps to early detect maternal and newborn pathologies in postpartum. In low-middle income countries, such as Benin, postnatal consultation rates are quite low. This is even more alarming in rural areas. This study aims to search factors associated with postnatal care visit. A cross-sectional study, conducted in Sèmè-kpodji, southern Benin, included 339 women who have delivered between January 2015 and January 2016. Sociodemographic information and data concerning women gynecological status and health center services management have been analyzed by logistic regression. Postnatal care visit rate was 12.68%. Primiparous mothers (OR=2.57 [1.15-3.02]), communication session of change of behavior (OR=1.98 [1.62-3.14]), secondary level of education (OR=1.23 [1.07-2.11]) and good quality of reception at health center (OR=1.75 [1.25-3.45]) were significant determinants of postnatal care visit. We lightened the benefit effect of communication session during antepartum. These strategies need to be strengthened by targeting older women. It is also necessary to increase the level of education of women.
Recurrence and Mortality of Melanoma In Situ of the Trunk or Extremities: A Surveillance, Epidemiology, and End Results Analysis.

BACKGROUND Recent studies demonstrate comparable outcomes of Mohs micrographic surgery (MMS) versus local excision (LE) for melanoma in situ. These studies are limited by their focus on the head and neck. OBJECTIVE The primary objective was to compare 5-year overall and melanoma-specific mortality among patients with melanoma in situ of the trunk or extremities who undergo MMS versus LE. The secondary objective was to compare 5-year local recurrence among the same cohort of patients who undergo MMS versus LE. MATERIALS AND METHODS The Surveillance, Epidemiology, and End Results (SEER) database (2000-2015) was queried to identify patients who underwent MMS versus LE for melanoma in situ of the trunk, upper extremities, or lower extremities. Outcomes were 5-year recurrence, melanoma-specific mortality, and overall mortality. Multivariable regression analyses were performed. RESULTS Thirty three thousand nine hundred eighty-three patients underwent surgical treatment (MMS 3%; LE 97%). In adjusted analyses, there was no difference in local recurrence (hazard ratio [HR] 1.00, 95% confidence interval [CI] 0.56-1.78), melanoma-specific mortality (HR 0.89, 95% CI 0.12-6.47), nor overall mortality (HR 1.10, 95% CI 0.82-1.48) between MMS versus LE. CONCLUSION There is no difference of 5-year local recurrence, melanoma-specific mortality, nor overall mortality associated with MMS versus LE for melanoma in situ of the trunk or extremities.
Importance of nurse caring behaviors as perceived by patients after myocardial infarction: A replication study

This study replicates Cronin and Harrison's (1988) study which examined nurse caring behaviors perceived by myocardial infarction (MI) patients (n=40) using the Caring Behaviors Assessment (CBA). Reliability ranged from 0.69 to 0.89. Findings support Cronin and Harrison's study (1988), with items as "knows how to handle equipment", "check my condition closely", and "knows how to give shots, IV's, etc." as most important nurse caring behaviors. "Talk to me about my life outside the hospital" and "visit me if I move to another hospital unit" were identified as least important nurse caring behaviors. Kruskal-Wallis one-way ANOVA and Mann-Whitney U test were used to examine responses to the CBA in relation to demographic variables of age, sex, occupation, educational level, length of Coronary care unit (CCU) stay, previous admission to CCU, previous admission for chest pain, and previous admission to the hospital. No findings at the p = 0.05 were noted. Critical Care Nurses need awareness of patient perceptions of important nurse caring behaviors.
Pharmacology of Mikania genus: A systematic review

Genus Mikania, in which “guaco” species are included, encloses many species of pharmaceutical interest that are well distributed throughout South America. This work aims to make a systematic review of the clinical and nonclinical data already published about some Mikania species and their existing products, available in the pharmaceutical market. As usual, some species are more studied than others and the most studied species to date are Mikania glomerata, Mikania laevigata, Mikania scandens, and Mikania micrantha. The first two are widely used in Brazil to treat respiratory disorders and are available in different preparations marketed in retail pharmaceutical stores. Among the reported activities, anti-inflammatory, analgesic, antibacterial, and central nervous system activities were the most tested since they are directly related to the popular use of some species of this genus. In addition, a noteworthy amount of toxicological studies in animals are published in the literature. Thus, this systematic review aims to gather knowledge about Mikania genus and consequently to contribute for a safer use of derivatives of its species.
The relationship between obesity, sex difference, and fatigue in patients with multiple sclerosis

DOI: 10.4328/JCAM.6023 Received: 17.09. 2018 Accepted: 01.10. 2018 Published Online: 02.10. 2018 Printed: 01.11. 2018 J Clin Anal Med 2018;9(6): 582-5 Corresponding Author: Özlem Ethemoğlu, Department of Neurology, Harran University School of Medicine, Sanlıurfa, Turkey. T. : +90 4143444444 F. : +90 4143183192 E-Mail: ozlem_uzunkaya@hotmail.com ORCID ID: 0000-0002-7873-910X Abstract Aim: Obesity is a risk factor for autoimmune disorders and worsens the disease process. The purpose of this study was to investigate the association between the body mass index (BMI), sex differences and fatigue in MS patients compared to healthy controls. Material and Method: Our study consisted of 59 MS patients (37 females, 22 males) and 45 healthy controls. Medical history of MS patients, including the duration of illness, BMI, Fatigue Severity Scale (FSS) number of annual episodes, demographic data (sex, age) and BMI and fatigue severity of healthy control group were recorded. Results: The female MS patients had a significantly higher mean BMI than the control group and a significant positive correlation between BMI and Extended Disability Scale Score (EDSS) and fatigue. There was no significant difference between the male MS patients’ BMI and that of controls. Obese MS patient group had a significantly higher mean fatigue level than the normoweight and overweight ones and significantly higher mean annual attack number than the normoweight MS group. In the female MS patients group, the mean BMI and EDSS of Fatigue Severity Scale (FSS) ≥4 group were significantly higher than of FSS <4 group but there was no significant correlation between the FSS ≥4 and FSS <4 groups in the male MS patients. Discussion: These findings suggest that being obese in MS patients may affect attacks via inflammatory pathway as well as disability, particularly so in women; they also show the necessity of approaches encouraging weight loss for MS treatment
Noncoding regions underpin avian bill shape diversification at macroevolutionary scales

Recent progress has been made in identifying genomic regions implicated in trait evolution on a microevolutionary scale in many species, but whether these are relevant over macroevolutionary time remains unclear. Here, we directly address this fundamental question using bird beak shape, a key evolutionary innovation linked to patterns of resource use, divergence, and speciation, as a model trait. We integrate class-wide geometric-morphometric analyses with evolutionary sequence analyses of 10,322 protein-coding genes as well as 229,001 genomic regions spanning 72 species. We identify 1434 protein-coding genes and 39,806 noncoding regions for which molecular rates were significantly related to rates of bill shape evolution. We show that homologs of the identified protein-coding genes as well as genes in close proximity to the identified noncoding regions are involved in craniofacial embryo development in mammals. They are associated with embryonic stem cell pathways, including BMP and Wnt signaling, both of which have repeatedly been implicated in the morphological development of avian beaks. This suggests that identifying genotype-phenotype association on a genome-wide scale over macroevolutionary time is feasible. Although the coding and noncoding gene sets are associated with similar pathways, the actual genes are highly distinct, with significantly reduced overlap between them and bill-related phenotype associations specific to noncoding loci. Evidence for signatures of recent diversifying selection on our identified noncoding loci in Darwin finch populations further suggests that regulatory rather than coding changes are major drivers of morphological diversification over macroevolutionary times.
Importance of cannabinoids in the functioning of the central nervous system

Authors’ contribution Wkład autorów: A. Study design/planning zaplanowanie badań B. Data collection/entry zebranie danych C. Data analysis/statistics dane – analiza i statystyki D. Data interpretation interpretacja danych E. Preparation of manuscript przygotowanie artykułu F. Literature analysis/search wyszukiwanie i analiza literatury G. Funds collection zebranie funduszy Summary At present, there is a great emphasis of public opinion on the legalisation of medical marijuana, i.e. the top parts of the cannabis plants rich in tetrahydrocannabinol (THC). Nevertheless, in the cannabis plants, there are many various cannabinoids, including cannabidiol (CBD). Scientific reports to-date indicate the possibility for using pharmacologically active cannabinoids in the treatment of such diseases/symptoms as: anorexia, vomiting, neuropathic pain, inflammatory diseases, multiple sclerosis, degenerative diseases of the central nervous system (Parkinson’s disease, Huntington’s disease, Alzheimer’s disease, Tourette’s syndrome), epilepsy, schizophrenia, and obesity. The article presents up-to-date information on the results of experimental studies concerning the effectiveness of cannabinoids, with particular consideration of diseases related with the central nervous system, including epilepsy, neuropathic pain, mental disorders, as well as obesity and anorexia.
Evaluation of vitamin D3 metabolites in Callithrix jacchus (common marmoset)

Vitamin D3 (cholecalciferol) is endogenously produced in the skin of primates when exposed to the appropriate wavelengths of ultraviolet light (UV‐B). Common marmosets (Callithrix jacchus) maintained indoors require dietary provision of vitamin D3 due to lack of sunlight exposure. The minimum dietary vitamin D3 requirement and the maximum amount of vitamin D3 that can be metabolized by marmosets is unknown. Observations of metabolic bone disease and gastrointestinal malabsorption have led to wide variation in dietary vitamin D3 provision amongst research institutions, with resulting variation in circulating 25‐hydroxyvitamin D3 (25(OH)D3), the accepted marker for vitamin D sufficiency/deficiency. Multiple studies have reported serum 25(OH)D3 in captive marmosets, but 25(OH)D3 is not the final product of vitamin D3 metabolism. In addition to serum 25(OH)D3, we measured the most physiologically active metabolite, 1,25‐dihydroxyvitamin D3 (1,25(OH)2D3), and the less well understood metabolite, 24,25‐dihydroxyvitamin D3 (24,25(OH)2D3) to characterize the marmoset's ability to metabolize dietary vitamin D3. We present vitamin D3 metabolite and related serum chemistry value colony reference ranges in marmosets provided diets with 26,367 (Colony A, N = 113) or 8,888 (Colony B, N = 52) international units (IU) of dietary vitamin D3 per kilogram of dry matter. Colony A marmosets had higher serum 25(OH)D3 (426 ng/ml [SD 200] vs. 215 ng/ml [SD 113]) and 24,25(OH)2D3 (53 ng/ml [SD 35] vs. 7 ng/ml [SD 5]). There was no difference in serum 1,25(OH)2D3 between the colonies. Serum 1,25(OH)2D3 increased and 25(OH)D3 decreased with age, but the effect was weak. Marmosets tightly regulate metabolism of dietary vitamin D3 into the active metabolite 1,25(OH)2D3; excess 25(OH)D3 is metabolized into 24,25(OH)2D3. This ability explains the tolerance of high levels of dietary vitamin D3 by marmosets, however, our data suggest that these high dietary levels are not required.
Autogenous leucocyte-rich and platelet-rich fibrin for the treatment of leg venous ulcer: a randomized control study

Background Venous ulcer (VU) is a serious health problem that has no satisfactory treatment. Platelet-rich fibrin (PRF) is one of regenerative medicines that promote wound healing by sustained release of growth factor (GF) and protein matrix for more than 7 days. Aim This study aims to evaluate the efficacy and safety of autologous leukocyte-platelet-rich fibrin (L-PRF) with venous leg ulcer. Patients and methods A randomized controlled study was conducted that included 36 patients with VUs. The eligible patients were enrolled in one of two groups (PRF and control groups) according to randomization schedule. Each group included 18 patients. The PRF group was treated with autologous L-PRF dressing, and dressing change was done once weekly. The control group was treated with conventional dressing of VU, but dressing change was done once in 2 days. Results The mean percentage of wound reduction of PRF group was found significantly higher than that of control group. There was a statistically significant difference between the PRF group and control group regarding the rate of completely healed ulcer at the fourth week for ulcer size less than 10 cm2 and at the seventh week for ulcer size more than 10 cm2. Conclusion Autologous L-PRF is effective and safe for treatment of venous leg ulcer.