Miracle-dz/UniFAR-FTUs huggingface dataset:
Decoding the expression pattern of MUC3A in gastric adenocarcinoma: unveiling the key to successful immunotherapy

ABSTRACT Aims Despite the promise of immunotherapy for gastric adenocarcinoma, resistance is common, necessitating the validation of new targets. Based on our previous bioinformatics analysis, the MUC3A antigen emerged as a promising candidate for immunotherapy against gastric adenocarcinoma. However, a comprehensive understanding of its expression at protein level remains elusive, despite its crucial role in determining clinical response. We also sought to establish a connection between the expression pattern and relevant clinical variables of the disease, whenever feasible. Methods Immunohistochemistry was used to determine the percentage of MUC3A-positive tumor cells in primary (PT) and metastatic tumor (MT) sites of 190 gastric adenocarcinoma patients. We also evaluated the association between MUC3A expression and variables such as Lauren classification, history of neoadjuvant chemotherapy and/or radiotherapy, and overall patient survival. Results Median MUC3A expression was 50% in PT and 70% in MT sites, exhibiting a positive correlation. MT intestinal type showed significantly higher MUC3A expression compared to other types. Neoadjuvant therapy history did not affect MUC3A expression. Higher MUC3A expression correlated with improved survival. Conclusions Based on our previous bioinformatics data and the consistently high expression of MUC3A on gastric tumor cells, we propose advancing experimental aspects of anti-MUC3A immunotherapy for gastric adenocarcinoma.
Relationship between Husband's Social Support and Participation in Pregnant Women Class in Denpasar City in 2019

The Pregnant Women class program is one of the government programs to increase the knowledge of pregnant women about pregnancy, preparation for childbirth, postpartum, newborns, and toddler development so that mothers are expected to be able to identify health problems experienced, but maternal participation in the class of pregnant women is low. The husband's social support is a strengthening factor for mothers to be able to participate in classes for pregnant women. This study aims to see whether there is a relationship between a husband's social support and participation in classes for pregnant women. This study is an observational analytical study with a cross-sectional approach. The sampling technique is non-probability sampling by consecutive sampling of 78 people. This research was conducted from April 1 to May 1, 2019, at the Denpasar City Health Center. The results showed that most of the husband's social support was weak (56%) and mothers did not participate in classes for pregnant women (56%). Statistical tests with the correlation of contingency coefficients obtained ρ = 0.000 value and r value = 0.707, meaning that there is a strong relationship between the husband's social support and participation in pregnant women's classes. The implication of this study is to increase knowledge related to husbands' social support factors that play a role in women's participation in pregnant women's classes.
Petrography and Geochemistry of the Anyaboni Formation of Kwahu Group, Voltaian Supergroup, Ghana: Implications for Provenance and Uranium Exploration

II Dedication. III Acknowledgement. IV List of Figures. IX List of Tables.XIV Chapter 1: Introduction. 1 1.1 Background. 1 1.2 Problem Statement. 2 1.3 Justification. 3 1.4 Research Objectives. 4 1.5 Location, Physiography and Geology of study area. 5 1.5. 1 Geographic location. 5 1.5. 2 Accessibility. 5 1.5. 3 Drainage and relief. 5 1.5. 4 Climate. 6 1.5. 5 Vegetation and soil. 6 Chapter 2: Literature Review. 8 2.1 Geology of Ghana. 8 2.2 Geology of the Voltaian Supergroup. 8 University of Ghana http://ugspace.ug. edu.gh
Snow Accumulation Variability at the South Pole From 1983 to 2020, Associated With Central Tropical Pacific Forcing

Despite a variety of efforts made to measure snow accumulation at the South Pole (SP), snow accumulation changes and their mechanism have not yet been fully explained. Here, SP stake farm measurements, global sea surface temperature observations, and atmospheric circulation data from European Centre for Medium‐Range Weather Forecasts Reanalysis version 5 were used to investigate the annual and seasonal snow accumulation changes at the SP during 1983–2020, and their association with central tropical Pacific Sea surface temperature variations. SP annual snow accumulation decreased significantly for the 1983–2007 period at a rate of −39.7 ± 1.4 mm decade−1, but switched to a dramatically positive trend during 2008–2020 (108.7 ± 2.7 mm decade−1), with the strongest increase in the austral autumn. The switch to a dramatically upward trend can largely be attributed to a cyclonic anomaly over the South Atlantic and an anticyclonic anomaly over the Drake Passage, causing the enhanced advection of warm and wet air into the SP. These circulation patterns were generated by an atmospheric Rossby wave train forced by rapid warming in the central tropical Pacific during 2008–2020.
Progress in diagnosis and treatment of difficult-to-treat asthma in children

At present, medications containing inhaled corticosteroids (ICS-containing) are the keystones of asthma treatment. The majority of asthmatic children can significantly improve clinical outcomes with little worsening by standardized inhaled glucocorticoid treatment, but there is still a small proportion of children who are unable to achieve good symptom control even after the maximum standardized treatment, known as ‘children with difficult-to-treat asthma (DA)’. The high heterogeneity of DA makes therapy challenging and expensive, which poses a serious risk to children’s health and makes it extremely difficult for clinical physicians to accurately identify and treat children with DA. This article reviews the definition, evaluation, and treatment of this asthma in order to provide a reference for optimal clinical decision-making.
Numerical Simulations of Gulf Stream Meanders and Eddies and Their Effects on the Cross-Shelf Transport off the Carolina Coast

LIU, XIAOMING. Numerical Simulations of Gulf Stream Meanders and Eddies and Their Effects on the Cross-Shelf Transport off the Carolina Coast. (Under the direction of Dr. Lian Xie.) Gulf Stream meanders and eddies off the Carolina coast are studied using an ocean numerical model. Numerical simulation results show that the isobathic curvature in the vicinity of the Charleston Bump has great effect on the development and evolution of Gulf Stream meanders and eddies, and the formation of the Charleston Trough, a Gulf Stream meander that appears as a low pressure or depressed water surface region downstream of the bump, is the result of the combined effect of the Charleston Bump and the isobathic curvature in the region. The isobathic curvature plays a major role in enhancing the baroclinic and barotropic energy transfer rates, whereas the bump provided a localized mechanism to maximize the energy transfer rate downstream of the Charleston Bump. The effects of the Gulf Stream meanders and eddies on the cross-shelf transport near the Carolina coast are also studied in the ocean numerical model. There are two factors that affect the ocean circulations on the continental shelf off the North and South Carolina coast: wind and the Gulf Stream meanders and eddies. It is concluded that the combination of the wind effect and the effect of the Gulf Stream meanders and eddies caused the red tide bloom event in the North Carolina near shore waters in October 1987. Neither wind alone nor the Gulf Stream meander/eddy alone is sufficient to transport the passive tracer to the near-shore area. NUMERICAL SIMULATIONS OF GULF STREAM MEANDERS AND EDDIES AND THEIR EFFECTS ON THE CROSS-SHELF TRANSPORT OFF THE CAROLINA COAST
Programmed death receptor 1 (PD‐1) ligand Fc fusion proteins reduce T‐cell proliferation in vitro independently of PD‐1

Abstract Programmed death receptor 1 (PD‐1) is an inhibitory receptor on T cells shown to restrain T‐cell proliferation. PD‐1 immune checkpoint blockade has emerged as a highly promising approach in cancer treatment. Much of our understanding of the function of PD‐1 is derived from in vitro T‐cell activation assays. Here we set out to further investigate how T cells integrate inhibitory signals such as PD‐1 in vitro using the PD‐1 agonist, PD‐1 ligand 1 (PD‐L1) fusion protein (PD‐L1.Fc), coimmobilized alongside anti‐CD3 agonist monoclonal antibody (mAb) on plates to deliver PD‐1 signals to wild‐type and PD‐1−/− CD8+ T cells. Surprisingly, we found that the PD‐L1.Fc fusion protein inhibited T‐cell proliferation independently of PD‐1. This PD‐L1.Fc inhibition was observed in the presence and absence of CD28 and interleukin‐2 signaling. Binding of PD‐L1.Fc was restricted to PD‐1–expressing T cells and thus inhibition was not mediated by the interaction of PD‐L1.Fc with CD80 or other yet unknown binding partners. Furthermore, a similar PD‐1–independent reduction of T‐cell proliferation was observed with plate‐bound PD‐L2.Fc. Hence, our results suggest that the coimmobilization of PD‐1 ligand fusion proteins with anti‐CD3 mAb leads to a reduction of T‐cell engagement with plate‐bound anti‐CD3 mAb. This study demonstrates a nonspecific mechanism of T‐cell inhibition when PD‐L1.Fc or PD‐L2.Fc fusion proteins are delivered in a plate‐bound coimmobilization assay and highlights the importance of careful optimization of assay systems and reagents when interpreting their influence on T‐cell proliferation.
Viscoelastic reverse time migration with attenuation compensation

ABSTRACTWe have developed a theory of viscoelastic reverse time migration (RTM). The main feature of viscoelastic RTM is a compensation for P- and S-wave attenuation effects in seismic images during migration. The forward modeling engine is based on a viscoelastic wave equation involving fractional Laplacians. Because of the decoupled attenuation property, wave propagation can be simulated in three scenarios, i.e., only the amplitude loss effect, only the phase dispersion effect, or both effects simultaneously. This separation brings practical flexibility to studying attenuation effects on wave propagation and imaging. The backward modeling operator is constructed by reversing the sign of first-order time derivative amplitude loss operators. Synthetic examples determine the ability of viscoelastic RTM to illuminate degraded areas and shadow zones caused by attenuation. Numerical experiments also reveal that Q-compensated imaging is noticeably more accurate in kinematics and dynamics than elastic imaging i.
Sources of genetic resistance to Fusarium wilt (Fusarium oxysporum f. sp tracheiphilum) in cowpea (Vigna unguiculata (L.) Walp.) and comparison of inoculum concentration levels

Abstract Fusarium wilt caused by Fusarium oxysporum f. sp tracheiphilum (Fot) is a soil-borne fungal disease of significant constraint to cowpea production in West Africa. The disease infection can cause up to 100% yield loss in highly infested fields. The most effective control strategy is the use of resistant varieties. Sixty cowpea germplasm collections were screened for resistance to F. oxysporum. The result revealed that only two (TVu 134 and TVu 410) of the germplasm showed a high level of resistance when subjected to artificial epiphytotic and innovative seedling root dip screening methods using three inoculum concentration levels. These two cultivars can be used directly by farmers or as potential donors for developing resistant cultivars against F. oxysporum. The study also identified useful polymorphic SSR markers associated with resistant and susceptible parents, which will significantly enhance the breeding programs in developing varieties’ resistance to the disease.
Surface Modification and Characterization of Coconut Shell-Based Activated Carbon Subjected to Acidic and Alkaline Treatments

Activated carbon derived from agricultural biomass has been increasingly recognized as a multifunctional material for various applications according to its physicochemical characteristics. The application of activated carbon in adsorption process mainly depends on the surface chemistry and pore structure which is greatly influenced by the treatment method. This study aims to compare the textural characteristics, surface chemistry and surface morphology of coconut shell-based activated carbon modified using chemical surface treatments with hydrochloric acid (HCl) and sodium hydroxide (NaOH). The untreated and treated activated carbons were characterized for their physical and chemical properties including the Fourier transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM) and textural characterization. The FTIR spectra displayed bands confirming the presence of carboxyl, hydroxyl and carbonyl functional groups. The Brunauer–Emmett–Teller (BET) surface area of the untreated activated carbon was 436 m2/g whereas the surface area of the activated carbon modified using 1M NaOH, 1M HCl and 2M HCl was 346, 525 and 372 m2/g, respectively. SEM micrographs showed that many large pores in a honeycomb shape were clearly found on the surface of 1M HCl sample. The pore structure of the activated carbon treated with 2M HCl and NaOH was partially destroyed or enlarged, which decreased the BET surface area. The modification of the coconut shell-based activated carbon with acidic and alkaline treatments has successfully altered the surface functional groups, surface morphology and textural properties of the activated carbon which could improve its adsorptive selectivity on a certain adsorbate.
An integrated UAV-borne lidar system for 3D habitat mapping in three forest ecosystems across China

ABSTRACT In recent decades, global biodiversity has gradually diminished due to the increasing pressure from anthropogenic activities and climatic change. Accurate estimations of spatially continuous three-dimensional (3D) vegetation structures and terrain information are prerequisites for biodiversity studies, which are usually unavailable in current ecosystem-wide studies. Although the airborne lidar technique has been successfully used for mapping 3D vegetation structures at landscape and regional scales, the relatively high cost of airborne lidar flight mission has significantly limited its applications. The unmanned aerial vehicle (UAV) provides an alternative platform for lidar data acquisition, which can largely lower the cost and provide denser lidar points compared with airborne lidar. In this study, we implemented a low-cost UAV-borne lidar system, including both a hardware system and a software system, to collect and process lidar data for biodiversity studies. The implemented UAV-borne lidar system was tested in three different ecosystems across China, including a needleleaf–broadleaf mixed forest, an evergreen broadleaf forest, and a mangrove forest. Various 3D vegetation structure parameters (e.g. canopy height model, canopy cover, leaf area index, aboveground biomass) were derived from the UAV-borne lidar data. The results show that the implemented UAV-borne lidar system can generate very high resolution 3D terrain and vegetation information. The developed UAV-based hardware and software systems provide a turn-key solution for the use of UAV-borne lidar data on biodiversity studies.
Polydopamine nanomaterials and their potential applications in the treatment of autoimmune diseases

Abstract The conventional treatment methods used for the management of autoimmune diseases (ADs) have limited efficacy and also exhibit significant side effects. Thus, identification of novel strategies to improve the efficacy and safety of ADs treatment is urgently required. Overactivated immune response and oxidative stress are common characteristics associated with ADs. Polydopamine (PDA), as a polymer material with good antioxidant and photothermal conversion properties, has displayed useful application potential against ADs. In addition, PDA possesses good biosafety, simple preparation, and easy functionalization, which is conducive for the pharmacological development of PDA nanomaterials with clinical transformation prospects. Here, we have first reviewed the preparation of PDA, the different functional integration strategies of PDA-based biomaterials, and their potential applications in ADs. Next, the mechanism of action of PDA in ADs has been elaborated in detail. Finally, the application opportunities and challenges linked with PDA nanomaterials for ADs treatment are discussed. This review is contributed to design reasonable and effective PDA nanomaterials for the diagnosis and treatment of ADs.
Air‐Sea Gas Exchange and Its Potential Influence on the Regional Fate of Polycyclic Aromatic Hydrocarbons in the East China Marginal Sea

To investigate the air‐sea gas exchange and its potential influence on the regional fate of polycyclic aromatic hydrocarbons (PAHs) in the East China Marginal Seas (ECMS), which consist of the East China Sea (ECS) and Yellow Sea (YS), we collected air and surface seawater samples of this area in the summer 2018 and winter 2019, respectively. Generally, PAHs underwent a strong volatilization process in the ECMS in both summer and winter. Good correlations between wind speed and the magnitude of air‐sea gas exchange were found for low molecular weight PAHs, suggesting the rate of their air‐sea gas exchange was influenced by the static stability of overlying atmosphere. However, such an influence for high molecular weight PAHs was constrained by their low Henry's law constant. Dissolved concentration of PAHs in surface seawater was another key factor regulating their air‐sea gas exchange, which not only influenced the rate of air‐sea gas exchange but also was involved in the exchange direction. Higher air‐sea gas exchange fluxes of PAHs in winter were attributed to their increasing dissolved concentrations in seawater during this season. A mass conservation analysis revealed a huge volatilization loss of PAHs from seawater to atmosphere, suggesting air‐sea gas exchange might be a key process to modulate the distribution and occurrence of PAHs in the ECS and YS. Such a loss of PAHs in seawater might be compensated by the sediment resuspension, which implied that the sedimentary deposit could serve as a secondary source of PAHs in seawater and overlying atmosphere.
Effects of positive end expiratory pressure during laryngeal mask airway anesthesia on respiratory parameters and abdominal pain in cataract surgery

Introduction: The purpose of this study was to evaluate the effects of positive end expiratory pressure (PEEP) on respiratory parameters and abdominal pain in patients ventilated with a laryngeal mask during cataract surgery. Methods: This clinical trial study included 80 patients in need of cataract surgery (40 in the group without PEEP and 40 in the group with PEEP at 5 cmH2O) who underwent laryngeal mask ventilation during general anesthesia. The parameters of dynamic compliance, pressure peak (Ppeak), tidal volume, SpO2, EtCO2, heart rate, non-invasive blood pressure, and abdominal pain were recorded at intervals of 1, 5, 10, and 20 minutes after the start of anesthesia and were compared between the two groups. Results: Respiratory parameters, heart rate and systolic and diastolic blood pressure were not significantly different between two groups, and only the mean tidal volume at 5, 10, and 20 minutes was significantly higher in the group without PEEP. Conclusion: Application of 5 cmH2O PEEP during ventilation with laryngeal mask in patients undergoing cataract surgery had no significant effect on improving respiratory parameters and pain in the gastric area.
Evaluation of measures to reduce nitrate loss to groundwater from tillage land

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Correlation between LST, NDVI and NDBI with reference to Urban Sprawling – A Case Study of Shimla city

The present study aims to explain the impacts of urban expansion on land surface temperature and vegetation of Shimla city using integrated techniques of remote sensing (RS) and geographic information system (GIS). Remote sensing technique often analyses the thermal characteristics of any area. This study monitors the interrelationship of land surface temperature (LST) with two spectral indices (normalized difference vegetation index and normalized difference built-up index) in Shimla City of India using Landsat 8 satellite for summer season for the period 2014 to 2023. There is a synergetic relationship between urban expansion and LST. The result showed a linear correlation between increasing the built-up area and the higher Land Surface Temperature values while lower Land Surface Temperature was associated with vegetation cover which means that the there was a positive relationship between the normalized difference built-up index values and the Land Surface Temperature while the relation between the normalized difference vegetation index and Land Surface Temperature was inverse. These results provide an insight into the systematic planning of the urban environment in the study.