Miracle-dz/UniFAR-FTUs huggingface dataset:
The Diagnosis and Management of Autism Spectrum Disorder (ASD) in Adult Females in the Presence or Absence of an Intellectual Disability

We review the reasons for the greater male predominance in the diagnosis of autism spectrum disorder in the non-intellectual disabled population and compare it to autism diagnosed in intellectually disabled individuals. Accurate and timely diagnosis is important, as it reduces health inequalities. Females often present later for the diagnosis. The differences are in core features, such as in social reciprocal interaction through ‘camouflaging’ and restricted repetitive behaviours, that are less noticeable in females and are potentially explained by the biological differences (female protective effect theory) and/or differences in presentation between the two sexes (female autism phenotype theory). Females more often present with internalising co-occurring conditions than males. We review these theories, highlighting the key differences and the impact of a diagnosis on females. We review methods to potentially improve diagnosis in females along with current and future management strategies.
Association of socio-demographic profile with types of tuberculosis among patients attending a rural DOTS centre in central Kerala, South India

Background: Re-evaluation of the epidemiological profile of tuberculosis (TB) patients can help to eliminate the number of cases. This study was aimed to analyse the association of socio-demographic profile with type of TB among patients attending a rural DOTS centre in central Kerala.Methods: A cross sectional study was conducted among TB patients at a rural DOTS clinic in central Kerala during January 2020-June 2021. Various socio-demographic parameters such as age, gender and socio-economic status and comorbidities of patients with pulmonary and extrapulmonary TB were retrieved from the DOTS register. The data was analyzed.Results: A total of 241 patients (134 males and 107 females) were enrolled. In general, age group 41-60 years showed maximum incidence (p=0.0283). Lower middle (32.7%) and middle class (36.5%) strata constituted the majority of burden (p=0.9091). The distribution of cases was not associated to occupation (p=0.06). Extrapulmonary form (55%) was found to be predominant with very poor awareness (p=0.06). A significant delay of at least 1-3 months in recognizing the symptoms and thus the clinical diagnosis particularly in extrapulmonary cases was found. Diabetes mellitus was the most frequent comorbidity in TB patients.Conclusions: The prevalence was most common in age group 41-60 years without any association to occupation. Since the diabetes mellitus is the most frequent comorbidity in TB patients, early screening will make an effective management. Society oriented awareness programme about the extrapulmonary TB is inevitable.
ANALISIS FAKTOR-FAKTOR YANG MEMPENGARUHI UNDERPRICING SAHAM PADA PENAWARAN SAHAM PERDANA DI BURSA EFEK INDONESIA

Penelitian empiris ini dimaksudkan untuk mengetahui pengaruh Reputasi Underwriter, Reputasi Auditor, Persentase Saham yang ditawarkan ke Publik, Financial Leverage, Profitabilitas (ROA), Profitabilitas (NPM), Current Ratio, Ukuran Perusahaan, Umur Perusahaan, dan Jenis Industri terhadap Underpricing saham pada penawaran saham perdana di Bursa Efek Indonesia tahun 2000-2012. Berdasarkan hasil analisis data, pengujian secara parsial menunjukkan variabelvariabel Reputasi Underwriter, Reputasi Auditor, Persentase Saham yang ditawarkan ke Publik, dan Jenis Industri tidak mempunyai pengaruh yang signifikan terhadap Underpricing, Variabel Financial Leverage berpengaruh positif dan signifikan terhadap Underpricing. Sedangkan Variabel Profitabilitas (ROA), Profitabilitas (NPM), Current Ratio, Ukuran Perusahaan, dan Umur Perusahaan berpengaruh negatif dan signifikan terhadap Underpricing saham pada penawaran saham perdana di Bursa Efek Indonesia. Kata kunci : Initial Public Offering, Initial Return dan Underpricing
Kenny Music Performance Anxiety Inventory: Contribution for the Portuguese Validation

(1) Background: The aim of the present study was to contribute to the validation of the Portuguese version of the Kenny Music Performance Anxiety Inventory (K-MPAI) and to study its psychometric properties. (2) Methods: A sample of 164 undergraduate music students in Portugal (62.2% female; mean age = 22.63; SD = 4.36) completed an online survey composed of the K-MPAI Portuguese version, the State Trait Anxiety Inventory, and a sociodemographic questionnaire. The K-MPAI psychometric properties were examined using exploratory factor analyses, known-group differences, and Cronbach’s alpha. (3) Results: A four-factor structure was identified, in line with recent validation of this measure in other countries: music performance anxiety-related symptoms, depression and hopelessness, parental support, and memory self-efficacy. Concurrent and known-group validity were established, and reliability scores were appropriate for the dimensions and total score. (4) Conclusions: The results provide initial evidence of the appropriateness of the Portuguese version of the K-MPAI.
Unlocking the Potential of Deep Learning for Migratory Waterbirds Monitoring Using Surveillance Video

Estimates of migratory waterbirds population provide the essential scientific basis to guide the conservation of coastal wetlands, which are heavily modified and threatened by economic development. New equipment and technology have been increasingly introduced in protected areas to expand the monitoring efforts, among which video surveillance and other unmanned devices are widely used in coastal wetlands. However, the massive amount of video records brings the dual challenge of storage and analysis. Manual analysis methods are time-consuming and error-prone, representing a significant bottleneck to rapid data processing and dissemination and application of results. Recently, video processing with deep learning has emerged as a solution, but its ability to accurately identify and count waterbirds across habitat types (e.g., mudflat, saltmarsh, and open water) is untested in coastal environments. In this study, we developed a two-step automatic waterbird monitoring framework. The first step involves automatic video segmentation, selection, processing, and mosaicking video footages into panorama images covering the entire monitoring area, which are subjected to the second step of counting and density estimation using a depth density estimation network (DDE). We tested the effectiveness and performance of the framework in Tiaozini, Jiangsu Province, China, which is a restored wetland, providing key high-tide roosting ground for migratory waterbirds in the East Asian–Australasian flyway. The results showed that our approach achieved an accuracy of 85.59%, outperforming many other popular deep learning algorithms. Furthermore, the standard error of our model was very small (se = 0.0004), suggesting the high stability of the method. The framework is computing effective—it takes about one minute to process a theme covering the entire site using a high-performance desktop computer. These results demonstrate that our framework can extract ecologically meaningful data and information from video surveillance footages accurately to assist biodiversity monitoring, fulfilling the gap in the efficient use of existing monitoring equipment deployed in protected areas.
Peer-Assisted Learning of Procedural Skill in Basti Karma (Medicated Enema)- A Pilot Study

Background- Peer Assisted Learning (PAL) is learning style with informative, interactive, and interesting learning. In clinical setting, PAL has been modestly used for the purpose of training of physical examination and general clinical skills examination, gross anatomy, communication skills training and resuscitation training. PAL is instruction-based model which used for teaching and learning in few medical schools and it has a great importance in today’s scenario. So, one cannot ignore PAL implementation in undergraduate teaching for enhancement of skill. Objectives- To develop competency in Ayurveda graduate to offer standardized Basti treatment as a service to mankind. Materials & methods- 20 potential undergraduate students were participated in the study and peer tutor role assigned to the rapid learner undergraduate students. Testing module (Erandamuladi Basti preparation and administration) was based on cognitive and psychomotor skill. Study was carried forward by introductory didactic lecture on Basti (medicated enema) preparation and its administration, introducing the concept of PAL, training session for peer tutors, PAL session with feedback and in last assessment of the participants through OSPE. Results- Near about95% students were in favor of PAL teaching method. And opined regarding good cooperative aspect, development of personal skills and keen study of subject by PAL method. Conclusion- PAL is one of way to develop competent Ayurveda graduate to provide standardized Basti treatment to mankind. Peer teaching is an easy effective way of equipping students with the procedural skill.
Comparative Analysis of Mitochondrial Genomes in Two Subspecies of the Sunwatcher Toad-Headed Agama (Phrynocephalus helioscopus): Prevalent Intraspecific Gene Rearrangements in Phrynocephalus

Intraspecific rearrangements of mitochondrial genomes are rarely reported in reptiles, even in vertebrates. The sunwatcher toad-headed agama, Phryncoephalus helioscopus, can serve as an excellent model for investigating the dynamic mitogenome structure at intraspecific level. To date, seven subspecies of P. helioscopus are well recognized, but little is known about the mitogenomic evolution among different subspecies. In this study, complete mitogenomes of subspecies P. helioscopus varius II and P. helioscopus cameranoi were determined by next-generation sequencing, and another P. helioscopus varius I retrieved from GenBank was compiled for comparative analysis. The nucleotide composition and the codon usage are similar to those previously published from toad-headed agamas. P. helioscopus varius II and P. helioscopus cameranoi have 23 tRNA genes, including standard 22 tRNA genes and one extra tRNA-Phe (tRNA-Phe duplication). Gene order and phylogenetic analyses in the genus Phrynocephalus support prevalent intraspecific gene rearrangement in P. helioscopus and other congener species including P. erythrurus, P. vlangalii, and P. forsythii. Six different mitochondrial gene arrangements are observed in Phrynocephalus. Overall, the occurrence of rearrangements may result from multiple independent structural dynamic events. The split of the two subspecies in P. helioscopus was dated at approximately 2.34 million years ago (Ma). Two types of gene rearrangements are found in the three mitogenomes of P. helioscopus, and this intraspecific rearrangement phenomenon can be explained by the tandem duplication/random loss (TDRL) model. Post duplication, the alternative loss types can occur in 0.23–0.72 Ma, suggesting that the duplication and fixation of these rearrangements can occur quite quickly. These findings highlight the need for more mitogenomes at the population level in order to better understand the potentially rampant intraspecific mitogenomic reorganization in Phrynocephalus.
Common cancer treatments targeting DNA double strand breaks affect long-term memory and relate to immediate early gene expression in a sex-dependent manner

DNA double strand breaks (DSBs) have been highly studied in the context of cancers, as DSBs can lead to apoptosis or tumorigenesis. Several pharmaceuticals are widely used to target DSBs during cancer therapy. Amifostine (WR-2721) and etoposide are two commonly used drugs: amifostine reduces DSBs, whereas etoposide increases DSBs. Recently, a novel role for DSBs in immediate early gene expression, learning, and memory has been suggested. Neither amifostine nor etoposide have been assessed for their effects on learning and memory without confounding factors. Moreover, sex-dependent effects of these drugs have not been reported. We administered amifostine or etoposide to 3–4-month-old male and female C57Bl/6J mice before or after training in fear conditioning and assessed learning, memory, and immediate early genes. We observed sex-dependent baseline and drug-induced differences, with females expressing higher cFos and FosB levels than males. These were affected by both amifostine and etoposide. Post-training injections of amifostine affected long-term contextual fear memory; etoposide affected contextual and cued fear memory. These data support the hypothesis that DSBs contribute to learning and memory, and that these could play a part in cognitive side effects during common treatment regimens. The sex-dependent effects also highlight an important factor when considering treatment plans.
A General Framework for Sorting Large Data Sets Using Independent Subarrays of Approximately Equal Length

Designing an efficient data sorting algorithm that requires less time and space complexity is essential for computer science, different engineering disciplines, data mining systems, wireless networks, and the Internet of things. This paper proposes a general low-complex data sorting framework that distinguishes the sorted or similar data, makes independent subarrays approximately in equal length, and sorts the subarrays’ data using one of the popular comparison-based sorting algorithms. Two frameworks, one for serial realization and another for parallel realization, are proposed. The time complexity analyses of the proposed framework demonstrate an improvement compared to the conventional Merge and Quick sorting algorithms. Following complexity analysis, the simulation results indicate slight improvements in the elapsed time and the number of swaps of the proposed serial Merge-based and Quick-based frameworks compared to the conventional ones for low/high variance integer/non-integer data sets, in different data sizes and the number of divisions. It is about (1–1.6%) to (3.5–4%) and (0.3–1.8%) to (2–4%) improvements in the elapsed times for 1, 2, 3, and 4 divisions, respectively for small and very large data sets in Merge-based and Quick-based scenarios. Although these improvements in serial realization are minor, making independent low-variance subarrays allows the sorted components to be extracted sequentially and gradually before the end of the sorting process. Also, it proposes a general framework for parallelizing conventional sorting algorithms using non-connected (independent) or connected (dependent) multi-core structures. As the second experiment, the numerical analyses that compare the results of the parallel realization of the proposed framework to the serial one in 1, 2, 3, and 4 divisions, show a speedup factor of (2 – 4) for small to (2 – 16) for very large data sets. The third experiment shows the effectiveness of the proposed parallel framework to the parallel sorting based on the random-access machine model. Finally, we prove that the mean-based pivot is as efficient as the median-based and much better than the random pivot for making subarrays of approximately equal length.
FIBRILASI ATRIUM SEBAGAI FAKTOR RISIKO KEJADIAN STROKE NON HEMORAGIK DI BAGIAN SARAF RSUD DR SOEDARSO PONTIANAK

Latar Belakang: Meningkatnya usia harapan hidup di Indonesia yang diperkirakan akan menempati posisi keenam tertinggi di dunia pada tahun 2020 cenderung meningkatkan risiko terjadinya penyakit vaskular. Salah satu penyakit vaskular berbahaya adalah stroke. Salah satu faktor risiko yang meningkatkan kejadian stroke non hemoragik adalah fibrilasi atrium. Tujuan: Penelitian ini bertujuan untuk mengetahui fibrilasi atrium sebagai faktor risiko kejadian stroke non hemoragik di RSUD dr. Soedarso Pontianak. Metodologi: Penelitian ini merupakan studi analitik dengan pendekatan case control yang dilakukan terhadap 32 subyek kelompok kasus dan 32 subyek penelitian kelompok kontrol yang dirawat inap di RSUD dr. Soedarso Pontianak. Data diperoleh dari rekam medik pasien dan pengambilan data dilakukan dengan proses matching usia dan jenis kelamin yang kemudian dianalisis menggunakan uji Mc. Nemar dengan tingkat kemaknaan p 1. Hasil: Didapatkan fibrilasi atrium sebagai faktor risiko kejadian stroke non hemoragik dengan nilai odds ratio 6,61 (IK 95% 1,66-26,349) dan terdapat hubungan yang bermakna antara fibrilasi atrium dan kejadian stroke non hemoragik (p=0,001). Kesimpulan: Fibrilasi atrium merupakan faktor risiko kejadian stroke non hemoragik di RSUD dr. Soedarso Pontianak. Kata kunci: faktor risiko, fibrilasi atrium, stroke non hemoragik.
MARINE ORGANIC CARBON AND RADIOCARBON—PRESENT AND FUTURE CHALLENGES

ABSTRACT We discuss present and developing techniques for studying radiocarbon in marine organic carbon (C). Bulk DOC (dissolved organic C) Δ14C measurements reveal information about the cycling time and sources of DOC in the ocean, yet they are time consuming and need to be streamlined. To further elucidate the cycling of DOC, various fractions have been separated from bulk DOC, through solid phase extraction of DOC, and ultrafiltration of high and low molecular weight DOC. Research using 14C of DOC and particulate organic C separated into organic fractions revealed that the acid insoluble fraction is similar in 14C signature to that of the lipid fraction. Plans for utilizing this methodology are described. Studies using compound specific radiocarbon analyses to study the origin of biomarkers in the marine environment are reviewed and plans for the future are outlined. Development of ramped pyrolysis oxidation methods are discussed and scientific questions addressed. A modified elemental analysis (EA) combustion reactor is described that allows high particulate organic C sample throughput by direct coupling with the MIniCArbonDAtingSystem.
Calculating the Intensity of Ventilation in Classrooms on the Basis of Measured Concentrations of Carbon Dioxide in Slovakia - Case Study

Abstract Air quality in a classroom is very important. According to a study by Wargocki et al (2012) a shortage of ventilation in the classroom reduces the ability of students to concentrate and causes an increase in the number of errors during the elaboration of tasks. The aim of this study was to contribute to the optimization of acquisition and operating costs of HVAC equipment and to ensure hygienic requirements of air quality in the indoor environment for classrooms. An analysis of calculation methods to determine the optimal ventilation rate is carried out and the proposed methodology is compared to experimental results. Values of concentrations of carbon dioxide and ventilation rates are verified by experimental measurements. The methodology most suitable for calculating ventilation rate in Slovakia is selected based on the comparison with the results from experimental measurements. Based on this a methodology for calculating ventilation rates for classrooms is determined.
APOE Polymorphism and Endocrine Functions in Subjects with Morbid Obesity Undergoing Bariatric Surgery

Background: Obesity is an interplay between genes and the environment, including lifestyle. The genetics of obesity is insufficiently understood. Apolipoprotein E (APOE) genetic polymorphism has been associated with a wide range of disorders. Knowing that some APOE alleles are associated with obesity and endocrine disorders that are common in obesity, the present study aimed at exploring associations between APOE polymorphisms and endocrine functions in subjects with obesity undergoing bariatric surgery. Methods: Analyses of hormones in blood collected before and one year after bariatric surgery were examined. The APOE alleles were grouped as follows: E2 = ε2ε2 + ε2ε3; E3 = ε3ε3 + ε2ε4; E4 = ε3ε4 + ε4ε4. The APOE groups were analysed as nominal and ordered groups (E2-E3-E4) with a linear mixed model to predict the hormonal effects of the groups. Results: Forty-nine women (79%) and thirteen (21%) men with a mean age of 47.7 (SD 8.5) years were included in the study. The adiponectin level was significantly lower (p < 0.05) in the E2 group compared with the E4 group. Adiponectin and cortisol were positively and negatively associated, respectively, with the ordered APOE groups. Conclusions: The ordered APOE groups E2-E3-E4 were significantly associated with high and low levels of adiponectin and cortisol, respectively. The findings indicate APOE-mediated effects on body weight and metabolic functions in subjects with morbid obesity.
Life stressors, social capital, and mental distress in older Asian Americans

ABSTRACT The present study examined how mental distress of older Asian Americans is influenced by various types of life stressors and social capital. Participants who were 60 and older (n = 533) were selected from the 2015 Asian American Quality of Life survey. A high level of mental distress was observed in the sample, particularly in the Korean and Vietnamese groups. Results of multivariate analyses indicated the detrimental effects of health- and immigration-related stressors and the beneficial effects of family and community resources and suggested ways to promote their mental health and well-being.
Spatial Distribution of Air Pollution, Hotspots and Sources in an Urban-Industrial Area in the Lisbon Metropolitan Area, Portugal—A Biomonitoring Approach

This study aimed to understand the influence of industries (including steelworks, lime factories, and industry of metal waste management and treatment) on the air quality of the urban-industrial area of Seixal (Portugal), where the local population has often expressed concerns regarding the air quality. The adopted strategy was based on biomonitoring of air pollution using transplanted lichens distributed over a grid to cover the study area. Moreover, the study was conducted during the first period of national lockdown due to COVID-19, whereas local industries kept their normal working schedule. Using a set of different statistical analysis approaches (such as enrichment and contamination factors, Spearman correlations, and evaluation of spatial patterns) to the chemical content of the exposed transplanted lichens, it was possible to assess hotspots of air pollution and to identify five sources affecting the local air quality: (i) a soil source of natural origin (based on Al, Si, and Ti), (ii) a soil source of natural and anthropogenic origins (based on Fe and Mg), (iii) a source from the local industrial activity, namely steelworks (based on Co, Cr, Mn, Pb, and Zn); (iv) a source from the road traffic (based on Cr, Cu, and Zn), and (v) a source of biomass burning (based on Br and K). The impact of the industries located in the study area on the local air quality was identified (namely, the steelworks), confirming the concerns of the local population. This valuable information is essential to improve future planning and optimize the assessment of particulate matter levels by reference methods, which will allow a quantitative analysis of the issue, based on national and European legislation, and to define the quantitative contribution of pollution sources and to design target mitigation measures to improve local air quality.