Miracle-dz/UniFAR-FTUs huggingface dataset:
Dihydropyrimidinase protects from DNA replication stress caused by cytotoxic metabolites

Metabolic alterations support cellular transformation. Noticeably, cellular transformation and cancer progression is associated with accumulation of dihydrouracil and dihydrothymine. However, it remains elusive how dihydropyrimidine metabolites affect cellular phenotypes. Dihydropyrimidines are degraded by dihydropyrimidinase (DHP). This zinc metalloenzyme is upregulated in solid tumors but not in the corresponding normal tissues. Here we show that DHP silencing in transformed cell lines is cytotoxic. Increasing the level of dihydropyrimidines inhibited DNA replication and transcription. It induced replication stress signaling by ATR and p53 stabilization. Remarkably, cells lacking DHP accumulated DNA-protein crosslinks (DPCs). Among DPCs, covalently trapped translesion DNA polymerase η contributed to the cytotoxicity of dihydropyrimidines. Furthermore, we show that the plant flavonoid dihydromyricetin inhibits the activity of recombinant human DHP. Cellular treatment with dihydromyricetin triggered DPCs-dependent DNA replication stress. This study defines dihydropyrimidines as potentially cytotoxic metabolites that may offer an opportunity for therapeutic-targeting of DHP activity in solid tumors.
Maps of student genres in engineering: a didactic model for teaching academic and professional Spanish language

Textual genres written by university students have become the focus of attention due to their importance within disciplinary learning (Parodi 2010). This paper has been developed in the field of study called student genres (Navarro 2018) and it uses the analysis of situated genre (Swales 2018, Perez-Llantada 2015) as its methodological platform. This study has two main objectives: a) to create a map of student genres from a learner corpus of the engineering field and b) to propose a didactic model for teaching academic and professional Spanish language using this map. Hence, linguistic research and description are linked to students‟ pedagogical needs (Breeze and Sancho Guinda 2017ab) and take into account the actual practice in the communities as well as the writers in these disciplines (Curry and Hanauer 2014). Finally, implications for configuring specific didactics in LSP are discussed.
Comparison of three evapotranspiration models in a rain-fed spring maize filed in the Loess Plateau, China

Accurate estimates of the rain-fed field evapotranspiration (ET) in the Loess Plateau of Northwest China is critical for predicting hydrologic processes, crop yield formation, and climate change. We simulated the ET variation in a rain-fed spring maize field in the eastern Loess Plateau using the Penman-Monteith (PM), Shuttleworth-Wallace (SW), and modified Priestley-Taylor (PTm) models. Then we compared their results with the observed ET using the eddy covariance (EC) method. Generally, the diurnal variation in estimated ET from the three models was similar to that of observed ET by the EC method. However, the PM model significantly underestimated ET. The ET estimates obtained from the SW and PTm models were approximately equal to the observed ET by the EC method. Considering the PTm model’s simplicity, we finally recommend it for rain-fed spring maize fields in the Loess Plateau. After precipitation, the estimated ET from the three models was significantly smaller than measured ET by the EC method, especially the PM model. After a frost, all three models failed to reflect the dramatic decrease in crop transpiration, and thus significantly overestimated ET.
Perception, Awareness and Consumer Insight Towards Purchase Intention Tanjak and Tenun Lejo Products

—This study aims to determine consumer perceptions, awareness level and Consumer Insight on Purchase Intention (buying interest) of the community to Tanjak and Tenun Lejo . The method in this research is quantitative research by using survey and observational method to society residing in Riau Province. Data analysis using associative techniques using SPSS version 20 program applications. The research variables are consumer perception, awareness, Consumer Insight and Purchase Intention. Data collection was done by probability sampling with Purposive sampling to 200 respondents. From this research it is known that consumer perception, Consumer Insight and Purchase Intention level to tanjak product and tenun lejo are high but awareness level is medium. Perception partially affects Purchase Intention but Awareness and Consumer Insight have no effect on purchase intention, together perceptions, awareness, consumer insight affect purchase intention.
Modeling of Tunneling Current in Bilayer Armchair Graphene Nanoribbon−Tunneling Field Effect Transistor by Using Airy Wave Function Approach

Metal oxide semiconductor field-effect transistor (MOSFET) has an important role in electric circuits because of its nano-size. However, MOSFETs have performance limitations to work in ultra-low power, leaky currents, short channel effects, and increased speed. These performance limitations make the tunneling field-effect transistor (TFET) an alternative to replace the MOSFET. In this study, a drain current on devices based on bilayer armchair graphene nanoribbon (BAGNR) was modeled using the Airy function approach. Solving the Schrödinger equation with the Airy function approach produces a transmittance value, and therefore the drain current value can be determined using the Launder formula with the Gauss Legendre Quadrature (GLQ) method. The results of the modeling show that the drain current value increases with the increasing gate voltage (Vg), drain voltage (Vd) and width of BAGNR, while the increase in oxide thickness and temperature decreases the drain current.
Intake and digestion of non-traditional feedstuffs by farmed collared peccary (Mammalia, Tayassuidae)

ABSTRACT To assess the ability of the collared peccary ( Pecari tajacu ) to digest dietary fiber, four adult male collared peccaries were randomly assigned to a 4 × 4 Latin square design to determine the effects of feeding non-traditional feed ingredients, taken from palm trees with different levels of dietary fiber, on intake and coefficient of total tract apparent digestibility (CTTAD) and mean retention time. Four experimental diets were provided ad libitum : corn and soybean meal-based control diet; [. ]
FACTORS IMPACTING MILLENNIAL ONLINE PURCHASE INTENTION WITH WEB EXPERIENCE INTENSITY AS MODERATION

This research attempts to explore the factors that are determining the millennial online purchase intentions. The indication leads to lifestyle, ease of use, e-service quality and consumer attitude as the predictors. Next, attitude is tested as a mediating variable. While the web experience intensity variable is tested as a moderator by comparing millennial generation web experiences < 7 years and > 7 years. The sample consisted of 200 millennial respondents aged 19-42 years. Data analyzed by the Structural Equestion Modeling (SEM) method with AMOS software. The result proves that lifestyle affects attitude of consumer online purchase, ease of use affects attitude of consumer online purchase, e-service quality affects attitude of consumer online purchase, attitudes of consumer online purchase affects online purchase intention, lifestyle affects online purchase intention, ease of use affects online purchase intention, e-service quality affects online purchase intention, attitudes of consumer online purchase mediates the effect of lifestyle on online purchase intention, attitudes of consumer online purchase mediates the influence of ease of use on online purchase intention, attitude mediates the influence of e-service quality online purchase intention, and web experience intensity does not moderate the effect of lifestyle, ease of use and e-service quality on online purchase intention. These all findings contribute to the realm of science and can be a reference for practical managers, especially in targeting the millenial online purchase intention. The novelty lies in the combination from the previous theories regarding direct effect, mediation effect, and moderation effect, and with the millenial as an object. The limitation resides in the scope of variables. Some implications also explains the clear pictures of the conditions that occur related to the variable under study.
Light-energized oxidation of organic wastes

Dye-sensitized aerobic photo-oxidation is a process by which many organic compounds may be oxidized chemically in the presence of photosensitizing dye, visible light, and molecular oxygen. In water solution, the sensitizer dye absorbs energy from visible light and transfers it to the? oxygen-substrate reaction system where photo-oxidation occurs. The dye can be recovered for reuse; only light en ergy, energy for aeration, and molecular oxygen are spent. Much scientific research has been done on dye-sensitized photo oxidation, but engineering application of the visible light process to water and waste treatment has received little atten tion. Kinney and Ivanuski1 refer only in cidentally to a few tests of dye-sensitized photolysis using visible light. While engineering applications of the process have been rare, the photolysis of waste materials by ultraviolet (uv) light has been the subject of much engineering research. There have been extensive stud ies of the kinetics of uv photolysis, and many substances such as metal ions (Fe2+, Fe3+, Ti2+, Zn2+), chlorine, sand, and some organic molecules have been tested for ef fectiveness as sensitizers for the uv pro cess. However, photolysis by uv light is not likely to find wide application as a water or waste treatment process primarily because of the power costs associated with generating uv light. Because dye-sensitized aerobic photo oxidation is energized by visible light, di rect sunlight might serve as an inexpensive energy source for the process. For photo oxidation applied to waste treatment, the substrate would be the waste molecules to be oxidized. The source of molecular oxy gen would be the dissolved oxygen (do) in the waste stream which is supplied by aeration.
Clinical swallowing evaluation in multiple sclerosis at a reference center in the center-west of Brazil

Background: In Multiple Sclerosis (MS), the physiology of deglutition can be compomised due the demyelination relapses, afecting both oral and pharyngeal stages. Symptoms control is an important part of the treatment of patients with MS, however, signs and symptoms of dysphagia may not be easily recognized by patients and caregivers. The management of swallowing reduces the risks of dehydration, malnutrition, pulmonary alterations and death. Objective: assess swallowing changes through a clinical evaluation in patients with MS ina reference and research center in a university hospital in the center west of Brazil Method: Cross-sectional study was carried out between November 2015 and August 2016, with 73 adult and elderly patients. The study included the oral motor system and vocal evaluation, and the functional evaluation of swallowing, using liquid-pasty, liquid, pasty and solid food consistencies. Results: Dysphagia was found in 30.14% of the patients, with significant alterations in the qualification and propulsion of the food bolus, featuring important impairment of the oral and pharyngeal phases of swallowing. Conclusion: This results was similar in the researched literature. Showing that dysphagia can appear in early stages of MS, compromising all stages of deglutition process.
ISOLATION AND CHARACTERIZATION OF MULTIDRUG RESISTANT BETA-LACTAMASE PRODUCING SALMONELLA ENTERICA FROM WILD MIGRATORY BIRDS

A multidrug resistant, an enteric pathogen, Salmonella enterica is the most frequent cause of food poisoning. They are gram negative, aerobic or facultative anaerobic bacteria belonging to the family Enterobacteriacae. Migratory birds serve as key factor, may disseminate Salmonella to the susceptible people through shared environment, fecal shedding and by mean of direct contact. The aim of present study was to investigate the occurrence of beta-lactamase genes (CTX-M and TEM) within antibiotic resistant strains of Salmonella enterica isolated from migratory birds. Present study incorporated isolation of 60 samples of Salmonella enterica from saliva, intestinal fluid and blood of different migratory birds. They are catalase positive, oxidase negative and H2S gas producer. The antibiotic resistance of all isolated strains (29) was tested against 10 antibiotics by Kirby-Bauer disc diffusion method. The antibiotics that were used include ciprofloxacin (5 μg), ceftriaxone (30 μg), meropenam (10 μg), aztreonam (30 μg), penicillin (10 μg), erythromycin (15 μg), streptomycin (10 μg), gentamycin (10 μg), vancomycin (10 μg) and imipenem (10 μg). These strains indicated more resistance towards penicillin (93%), streptomycin (100%), erythromycin (93%), aztreonam (62%) and vancomycin (90%) and low resistance towards ciprofloxacin (21%), ceftriaxone (54%) and imepenam (45%). For the detection of CTX-M and TEM gene in ciprofloxacin and ceftriaxone resistant strains, DNA was obtained through chemical method. These strains were further checked for the presence of CTX-M and TEM gene by polymerase chain reaction (PCR). PCR results demonstrated that all the strains contain TEM gene but CTX-M gene was not identified in any of these strains. PCR amplified product was sequenced, followed by BLAST, which confirmed the presence of TEM gene giving resistance to beta-lactam antibiotics.
Influence of Alcohol and Drug Consumption on Hepatitis C Treatment with Direct-Acting Antivirals

Background: People who inject drugs (PWID) and harmful alcohol drinkers have been traditionally excluded from Hepatitis C Virus (HCV) treatment because of a reduced effectiveness. With the appearance of direct-acting antivirals (DAA) the effectiveness could be similar. Objective: we evaluated the influence of harmful alcohol and drugs consumption on the effectiveness of the HCV treatment with DAA. Methods: 1792 patients were treated with DAA in 12 hospitals of the Spanish region of Castilla-La Mancha between 2004 and 2019. They were catalogued depending on their alcohol consumption (>30 g/ day and > 80 g/day), and antecedents of parenteral drug use, and the effectiveness of the treatment was evaluated according to the viral load 12 weeks after the end of treatment with the parameter “sustained viral response” (SVR12). Results: 23.1% were consumers of >30g/day, 16.1% > 80 g/day, and 21.4% PWID. The global SVR12 rate was 91.5%. SVR12 was 85.2% in consumers of >30/day (p=0.20), 84.7% in > 80 g/day (p=0.24) and 84% in PWID (p=<0.01). When excluded the patients lost to follow-up from the analyses (10.1-10.2% in alcohol consumers; 12.5% PWID), SVR12 rate was similar in alcohol consumers (p=0.26), although in PWID rose to 96.5% (p=0.52). Conclusions: the effectiveness with DAA treatment in HCV is similar in patients with and without alcohol consumption. In PWID the effectiveness is similar patients with an appropriate follow-up.
I Can’t Live Without Google Translate: A Close Look at the Use of Google Translate App by Second Language Learners in Saudi Arabia

Google Translate App (GTA) use is ubiquitous among second language learners in Saudi Arabia for translating between Arabic and English and vice versa. Learners perform various translation tasks drawing on different features of GTA. However, what specific features they draw on when using Google Translate, and how the app influences their English learning process is unknown. This study aims to answer the following research question: what are the affordances of GTA as perceived by second language learners in Saudi Arabia? The research participants were twelve second language learners at a university in Saudi Arabia. Focus group interviews and individual interviews were conducted to gather the data over six-weeks. Thematic analysis indicates that GTA provides five different modes of writing in English, offering options to use the app in-class and in everyday life, and serving as a language learning resource. The findings also indicate that the personal histories of learners with GTA related to their introduction to and frequency of using the app in everyday life, and the benefits they observed when doing so. The study recommends language instructors promote the use of the app as a mini dictionary, and encourage language learners to use it as a resource to ensure accurate spelling and pronunciation.
Wideband Double-Polarized Array of Cold-Electron Bolometers for OLIMPO Balloon Telescope

In this article, we propose a novel type of a wideband 2-D array of cold-electron bolometers (CEBs) sensitive to both polarizations of the incoming optical signal. This array was developed for osservatorio per il lontano infrarosso e le microonde su pallone orientabile (OLIMPO) balloon telescope with a requirement on bandwidth more than 10%. Sensitivity to both polarization components was achieved by a special meander-type arrangement of orthogonal L/2 dipoles. We present theoretical estimations for the optimal arrangement of 2-D arrays of CEBs, which allows achieving maximum efficiency in a wide band with the lowest noise equivalent power (NEP). A pixel layout with an optimal density of CEBs, sensitive to dual polarizations, and having more than 10% FWHM bandwidth at around 350 GHz was proposed and numerically analyzed. The layout consists of a periodic sparse array of orthogonal dipoles sensitive to both polarization components of the incoming signal. The numerical analysis confirmed that the sparse array is the most promising for a combination of high absorbing efficiency and low noise of the system and satisfying the 10% bandwidth requirements for the OLIMPO instrument. Different combinations of series and parallel connections of bolometers were considered for better noise properties to achieve the photon noise-limited level.
Croatian Crisis Management System's Response to Covid-19 Pandemic Through the Lens of a Systemic Resilience Model

We analyse the Croatian crisis management system’s response to COVID-19 pandemic in terms of Fath, Dean, and Katzmair’s model of resilience in social systems. We find that the Croatian crisis management system has successfully completed one cycle of the model. However, if the system is to achieve resilience, it also needs to replace the regime from before the crisis with a new regime that will simultaneously enable a life of relative normalcy and contain an excessive spread of the virus. Strengthening social cohesion and more bottom-up, emergent leadership might facilitate the search for a new regime. Small, local outbreaks represent small-scale disturbances that provide opportunities for the development of cohesion and bottom-up leadership from local, county, municipal and city-levels to the national level. The model used in this article better conveys the underlying complexity of crisis management systems than “the hammer and the dance” model, whereas the latter is better suited for public communication. Future work should extend this case study in terms of modelling approaches, the sample of countries, and the time covered. It can also be extended to lower, sub-national, as well as higher, supra-national levels, such as the EU.
Spatial, temporal and individual-based differences in nest-site visits and subsequent reproductive success in wild great tits

The behaviour of individual birds before and during the breeding period may be an important factor determining reproductive success. One commonly observed behaviour during the breeding period in many species is the visitation of multiple potential breeding sites. Much research has attempted to determine the function and consequences of this behaviour, but traditionally studies have been limited to not examining individual‐level behaviour, or only considering a small number of individuals. We used automated recording of RFID‐tagged birds visiting nestboxes to study a population of 80 great tits (Parus major) making > 3500 daily visits across 74 breeding sites, to quantify the frequency, spatial patterning, and temporal occurrence of this behaviour from the pre‐breeding period onwards. We argue that 1) the tight spatial clustering of visits, 2) juveniles visiting more sites than adults, and 3) males (but not females) continuing to visit other sites even as egg laying at their own nest occurs, indicate that territoriality and extra‐pair mating may underpin visitation behaviour. Further, we find that spatial clustering of female visits relates to increased clutch size and fledging success, while frequently visiting a preferred nesting site increases the likelihood of obtaining a breeding site but reduces subsequent reproductive output for both sexes. Our study offers new insight into the mechanisms potentially driving breeding site visitation behaviour, and demonstrates its relationship to individual fitness. We suggest that although visitation behaviour may be related to different components of fitness, future work should use experiments to fully assess the causal factors and effects of visitation behaviour.
Impact on energy saving and thermal comfort through the application of expanded polyurethane thermal insulation in Panama

Air conditioning systems are used every day on a global scale in a search for comfort, especially in places with very hot and humid climates. Panama classifies as one of those, therefore, the use of air conditioning systems attributes to a big part of nationwide electricity consumption. As the country grows, more of these systems are used daily in residential and labor sectors, and this takes a toll on the nationwide consumption of electricity. Part of the country’s strategy is increasing the energy generation capabilities, but the rational and efficient use of the energy that’s already available could substantially help the energy situation in the country. This research focuses on evaluating the viability of the use of polyurethane based thermal insulation in Panama, with and without the use of air conditioning systems, to evaluate the impact of this technology in the human comfort and in the electricity bill payed for consumers in Panama. Various tests were conducted to evaluate different aspects such as decrease in consumption and temperature gain inside experimental houses. Test results indicate a 44% decrease in electricity consumption due to the use of air conditioning systems under the installation of polyurethane insulation on ceiling and walls. This directly translates into a reduction of the cost of electric bills in homes and offices and may positively impact on the national electric energy demand. Keywords—Thermal Insulation, Expanded Polyurethane, Energy Efficiency, Air Conditioning,