Miracle-dz/UniFAR-FTUs huggingface dataset:
Parent's Stress and Quality of Life for Children Diagnosed with Autism

Background: Autism was currently one of the most prominent and widely discussed pediatric condition and was a set of neurodevelopmental disorders. Aim of study: The aim of this study was to assess parent's stress and quality of life for children diagnosed with autism. Design: A descriptive design was utilized to conduct this study. Settings: The study was carried out at outpatient clinics of Benha Specialized Pediatric Hospital, and Al–shohdaa Hospital at menoufia city. Sample: A convenient sample of (75) parents accompanied their autistic children were selected from the previously mentioned settings. Total of data collection: Five tools were used: Tool (1) A structured interviewing questionnaire. Tool (II) Developmental assessment for children, Tool (III) Childhood Autism Rating Scale (CARS) –Second Edition, Tool (IV) Parental stress Index-short form scale and Tool (V) Pediatric Quality Of Life 4.0 Generic Core Scale. Results: Less than half of the studied fathers were in the age groups 45 years old , and more than two fifth of the studied mothers were in the age groups less than 25 years old. More than two thirds of the studied parents have unsatisfactory knowledge regarding autism, while less than one third of them have satisfactory knowledge regarding autism. Less than half of the studied children had moderate autism less than half of the studied parent had moderate stress level and less than two thirds of studied children had low level quality of life. Conclusion: There was a highly statistically significant positive correlation between total parent's stress, knowledge, and total quality of life of their children. Recommendations: Providing training programs for parents of children diagnosed with autism, which helps them to be able to deal in the best way with their children.
GP-PDA Filter for Extended Target Tracking With Measurement Origin Uncertainty

Extended target tracking (ETT) is an issue in high-resolution radar surveillance, ship tracking, and video tracking. Most of the previous works focus on tracking an ellipsoidal extended target without measurement origin uncertainty (missed detections and clutter). In this paper, a new estimator called the Gaussian process probabilistic data association (GP-PDA) filter is proposed to track an irregularly shaped extended target with measurement origin uncertainty. First, a generalized measurement model for ETT using the Gaussian process (GP) is presented. Both the interior scattering points and the external clutter are considered in this model. Second, a GP-based gating technique is constructed to select validated measurements to feed the filter. Third, the GP-PDA filter is proposed to simultaneously estimate the kinematic state and the contour state of the extended target with measurement origin uncertainty. It is proven that the GP-PDA is a generalized version of the classic PDA, and the latter is a special case of the former in the point target tracking applications. Finally, the GP-based posterior Cramér–Rao lower bound (PCRLB) is derived to evaluate the performance of the ETT with measurement origin uncertainty. Two cases of the PCRLB are discussed, with the number of scattering points being known and unknown. Simulation results verify the effectiveness of the proposed method.
Combined approaches for increasing fetal hemoglobin (HbF) and de novo production of adult hemoglobin (HbA) in erythroid cells from β-thalassemia patients: treatment with HbF inducers and CRISPR-Cas9 based genome editing

Genome editing (GE) is one of the most efficient and useful molecular approaches to correct the effects of gene mutations in hereditary monogenetic diseases, including β-thalassemia. CRISPR-Cas9 gene editing has been proposed for effective correction of the β-thalassemia mutation, obtaining high-level “de novo” production of adult hemoglobin (HbA). In addition to the correction of the primary gene mutations causing β-thalassemia, several reports demonstrate that gene editing can be employed to increase fetal hemoglobin (HbF), obtaining important clinical benefits in treated β-thalassemia patients. This important objective can be achieved through CRISPR-Cas9 disruption of genes encoding transcriptional repressors of γ-globin gene expression (such as BCL11A, SOX6, KLF-1) or their binding sites in the HBG promoter, mimicking non-deletional and deletional HPFH mutations. These two approaches (β-globin gene correction and genome editing of the genes encoding repressors of γ-globin gene transcription) can be, at least in theory, combined. However, since multiplex CRISPR-Cas9 gene editing is associated with documented evidence concerning possible genotoxicity, this review is focused on the possibility to combine pharmacologically-mediated HbF induction protocols with the “de novo” production of HbA using CRISPR-Cas9 gene editing.
A New Fuzzy-Based Classification Method for Use in Smart/Precision Medicine

The development of information technology has had a significant impact on various areas of human activity, including medicine. It has led to the emergence of the phenomenon of Industry 4.0, which, in turn, led to the development of the concept of Medicine 4.0. Medicine 4.0, or smart medicine, can be considered as a structural association of such areas as AI-based medicine, telemedicine, and precision medicine. Each of these areas has its own characteristic data, along with the specifics of their processing and analysis. Nevertheless, at present, all these types of data must be processed simultaneously, in order to provide the most complete picture of the health of each individual patient. In this paper, after a brief analysis of the topic of medical data, a new classification method is proposed that allows the processing of the maximum number of data types. The specificity of this method is its use of a fuzzy classifier. The effectiveness of this method is confirmed by an analysis of the results from the classification of various types of data for medical applications and health problems. In this paper, as an illustration of the proposed method, a fuzzy decision tree has been used as the fuzzy classifier. The accuracy of the classification in terms of the proposed method, based on a fuzzy classifier, gives the best performance in comparison with crisp classifiers.
Management Practices of Deoni Cattle Rearers in their Native Tract: A Study in Bidar District, Karnataka, India

: The study conducted in Bidar district of Karnataka on Deoni cattle rearing practices from 120 Deoni cattle owners showed that the majority of the respondents (85.83%) were practicing both grazing and stall feeding methods. The use of natural service for impregnating the animals was preferred by the maximum number of respondents (93.33%), and bulls reared by the farmers from the village are being preferred for breeding (82.14%). However, the study also highlights some areas where improvement is required. For instance, while the majority of the respondents consult government veterinarians for animal diseases (68.33%) and deworming practices (65.83%), there is a need to educate them about the benefits of regular veterinary check-ups and preventative measures for animal health and productivity. Only 36.97% of the respondents kept their animals in pucca cattle sheds, a majority (50.83%) followed a full hand method of milking, and none of them used to clean the animals daily. Based on the findings, it can be concluded that there is a need for creating awareness on scientific cattle rearing practices, introduction of breed up-gradation programs, supply of quality semen, and provision of adequate inputs to make the rearing of Deoni cattle much more beneficial to the rearers. By implementing these measures, it is possible to enhance the productivity, health, and overall well-being of Deoni cattle and improve the livelihoods of cattle rearers in the region.
THE EFFECT OF COMBINED ULTRASOUND AND MC KENZIE ON IMPROVING FUNCTIONAL ABILITY IN PATIENTS WITH MYOGENIC LOW BACK PAIN

Low back pain is a musculoskeletal disorder with signs of pain in the area around the lower back, the incidence is mostly myogenic low back pain, it increases with age. Physiotherapy interventions used to improve functional ability with a combination of ultrasound and mc kenzie. The purpose of this study was to determine the effect of a combination of ultrasound and mc kenzie on improving functional abilities in patients with myogenic low back pain. This research design uses a type of quasi-experimental with a one group pretest and posttest approach, this study has 20 respondents using a sampling technique, namely purposive sampling. The effect of the combination of ultrasound and mc kenzie on functional ability in myogenic low back pain patients with a p-value = 0.001 (p <0.05). Based on the results of this study, it is stated that the combination of ultrasound and mc kenzie can improve functional ability in myogenic Low Back Pain patients performed 2 times a week for 4 weeks.
Theoretical Prerequisites for the Study of Male and Female Discourse in the Context of Masculine Cultural Pragmatics

Gender linguistics is an essential part of gender discourse. The main reason is the fact that people understand and create the world through the language they speak. In this context, "masculinity" and "femininity" are formed and developed differently due to languages and cultures. Studying languages from the perspective of gender linguistics is essential for understanding the peculiarities of cultures and intercultural relations. Within the framework of cross-cultural pragmatics, we analysed the discourse of men and women at the theoretical level and studied the causes of gender differentiation in language. To study gender differentiation in language, we analysed male and female discourse within the framework of intercultural pragmatics at the theoretical level of the cognitive paradigm and pragmatic semiology. The article deals with the practical value of addressing from the point of view of the cultural code, that is, the semiotic expression of national cultural norms. The cognitive-discursive analysis is carried out based on gender representations. The author uses the type of discourse, which is reflected at the level of topics, communicative methods and tactics, and national concepts, to demonstrate the conditionality of the functioning of gender representations. The language society uses for men and women varies from society to society and culture to culture. The fact that the dominant ideology in society is determined mainly by men makes women passive and condemns them to live in a language defined by men. The article is based on studies from a feminist perspective on language and gender relations. It shows that women are more prone to inflectional sentences because of the sense of insecurity attributed to them.
THE STUDY OF COMMUNITY AWARENESS ABOUT MULTIPLESCLEROSIS.

Maram M Alharbi, Raneem A Alrouji, Alanound Z Alsamari, Razan M almufarriji, Bayan A Alrabah, Ghaida S Alsuhaibani, Shatha S Alghamdi, Yara M Falata, Bayan S Aldebas and Rafif Z Othman. Medical students,college of medicine, Al Maarefa colleges for science & technology, Riyadh, Saudi Arabia. Manuscript Info Abstract . Manuscript History
PILOT DECISIONS ARE THE RESULT OF MANAGEMENT DETERMINING FLIGHT SAFETY

Aviation safety is the ultimate goal of aviation in both civil and military in several accident reports and data from the aviation safety directorate of the Indonesian Army Aviation Center (Puspenerbad) human factors rank first cause of accidents as much as 74%. The purpose of this study is to determine the magnitude of the influence Flight Experience and Flight Proficiency against pilots decision making which has implications for aviation safety. The method in this study used quantitative descriptive analysis, with 99 respondents. Data collection is carried out by distributing questionnaires Google Forms and analyzed with the app SmartPLS 4.0. The conclusions obtained in this study put Flight Experience and Flight Proficiency does not affect flight safety if not mediated by the pilot decision making and flight safety is affected by pilots decision making.
Modeling the Effect of Gestation Delay of Predator on the Stability of Bifurcating Periodic Solutions in Wetland Ecosystem

We investigate the effect of gestation delay of predator on the stability of the coexisting equilibrium of a wetland model for Keoladeo National Park. It is observed that there is a stability switches, and Hopf bifurcation occurs when the delay crosses some critical value. By applying the normal form theory and the center manifold theorem, the explicit formulae which determine the stability and direction of the bifurcating periodic solutions are determined. Computer simulations have been carried out to illustrate different analytical findings. Results indicate that the Hopf bifurcation is subcritical and the bifurcating periodic solution is unstable for the considered parameter.
Nursing Educational Guidelines to Enhance Competency- Based Practice among Nurses as Genetic Counselors

Background : The present study aimed to evaluate the efficacy of nursing educational guidelines to enhance competency-based practice among nurses as genetic counselors. Research design : A quasi-experimental design was used. Setting: data were collected from the oncology and outpatient departments at Benha university Hospital, Qaluobia governorate, Egypt. Subjects: Convenient sample of all available nurses (50) who were working in the oncology and outpatient departments during the data collection period. Tools of data collection: Three tools were utilized to collect data. 1) Structured questionnaires composed of 2 parts: Demographic characteristics and Nurse’s Knowledge regarding basics of genetics and genomic, 2) Nurses' attitude toward genetic counseling. 3) Check list to assess competency-based practice among nurses as genetic counselors. Results: 20% of the studied nurses had satisfactory level of knowledge pre educational guidelines which changed to 94% post guidelines (P<0.05). There were marked improvement in all items of nurses' competency-based practice post educational guidelines with highly statistical difference (P= 0.000). There were 56% of the studied nurses had positive attitude towards importance of genetic counseling post guidelines implementation compared to 14% pre guidelines implementation (P<0.05). Conclusion: the nursing educational guidelines had significant efficacy on improving the studied nurses’ knowledge, practice and attitude regarding basics of genetics and genomic. Recommendations: Incorporate the genetic course into the nursing curriculum and conduct continuous educational interventions to improve the competencies in genetics and genomics among nurses with different degrees and areas of practice .
Extranodal NK-/T-cell lymphoma, nasal type: what advances have been made in the last decade?

Extranodal NK-/T-cell lymphoma (ENKTCL) is a rare and highly aggressive malignancy with significant racial and geographic variations worldwide. In addition to the formerly “nasal-type” initial description, these lymphomas are predominantly extranodal in origin and typically cause vascular damage and tissue destruction, and although not fully understood, Epstein–Barr virus (EBV) has an important role in its pathogenesis. Initial assessment must include a hematopathology review of representative and viable tumor areas without necrosis for adequate immunohistochemistry studies, including EBV-encoded small RNA (EBER) in situ hybridization (ISH). Positron emission tomography with 18-fluorodeoxyglucose (18F-FDG-PET/CT) for accurate staging is essential, and most patients will have localized disease (IE/IIE) at diagnosis. Apart from other T-cell malignancies, the best treatment even for localized cases is combined modality therapy (chemotherapy plus radiotherapy) with non-anthracycline-based regimens. For advanced-stage disease, l-asparaginase-containing regimens have shown improved survival, but relapsed and refractory cases have very poor outcomes. Nowadays, even with a better understanding of pathogenic pathways, up-front therapy is completely based on chemotherapy and radiotherapy, and treatment-related mortality is not low. Future strategies targeting signaling pathways and immunotherapy are evolving, but we need to better identify those patients with dismal outcomes in a pre-emptive way. Given the rarity of the disease, international collaborations are urgently needed, and clinical trials are the way to change the future.
Plasma diagnostics using neutral lithium beam on the COMPASS tokamak

The doctoral thesis presents the diagnostic neutral lithium beam on the COMPASS tokamak in Prague. The technical part describes the system for injection of accelerated lithium beam into the COMPASS tokamak and the respective detection systems for beam emission spectroscopy. The physical part describes the analysis of measured spectroscopic data, with particular emphasis on density fluctuations in the edge plasma. Detailed analysis of turbulent structures outside of the confined plasma region is presented, as well as investigations of the ELM instabilities during high confinement mode plasma operation. The thesis also presents the development and proof-of-concept measurements of a new and unique diagnostic method atomic beam probe. The method uses detection of the ionized part of the beam for current density profile measurements in the plasma edge.
Bridging the Gap from Continuum Mechanics to Molecular Dynamics for Nanoscale Systems

Bending nanowires and nanoplates are widely used as flexible beams in Nano-Electro-Mechanical Systems for force and mass sensors. Usually, the vertical deflection and resonant frequencies of the nanowires and plates are the most crucial parameters in these systems. Deriving the mechanical theories specifically applicable to nanoscale materials and enhancing the accuracy of the mechanics of these nanoscale structures is still a bottle neck in designing nanotechnology. Typically, there are two different ways to accomplish the mechanical modeling for nanoscale materials, such as modeling with continuum mechanics by adding size effects and modeling from atomic scale theory. However, both of these methods have some fundamental issues or limitations and cannot be directly applied to accurately achieve accurate mechanical modeling for nanoscale materials. The hypothesis of this dissertation is that the Euler-Bernoulli or Timoshenko beam theory with surface effects, Eringen’s nonlocal elasticity and the corresponding nonlocal beam theories, and molecular dynamics simulations results should all be consistent for nanoscale structures with critical dimensions of 1-100nm. First, a more general solution of continuum beam theories with surface effect has been obtained and developed to investigate the surface effect on bending nanowires with the “core-shell” approach. Timoshenko beam theory with surface effects has been applied with consideration of shear effect and rotational inertia effect. Consequently, the limitation of aspect ratio of Euler-Bernoulli beam theory was eliminated. Second, the solutions of the resonant frequencies with surface stress effect and nonlocal effect have been compared. A bridging theory by incorporating surface properties with the nonlocal elasticity theory parameter e0 has been developed to bridge the classical beam theories with nonlocal beam theory at the nanoscale. Finally, molecular dynamics simulations have also been introduced to verify the above conclusions from the theoretical relation between the surface stress and nonlocal parameter. The molecular dynamics simulations found the same trends as the theoretical modeling predicts. An imaginary e0 was also found by calibrating e0 with the resonant frequencies obtained from the molecular dynamics simulations. The future work has been discussed at the end of the dissertation.
Chemical Constituents of Euphorbia stracheyi Boiss (Euphorbiaceae)

Euphorbia stracheyi Boiss was used for hemostasis, analgesia, and muscular regeneration in traditional Chinese medicine. To study the chemical constituents of E. stracheyi, the ethyl acetate part of the methanol extract of the whole plant was separated by silica gel, sephadex LH-20 column chromatography, and semi-preparative HPLC. The isolation led to the characterization of a new lathyrane type diterpenoid, euphostrachenol A (1), as well as eleven known compounds (2–11), including a lathyrane, three ingenane-type and two abietane-type diterpenoids, two ionones, and two flavonoids. The structures of these compounds were established using 1D- and 2D-NMR experiments, mass spectrometry, and X-ray crystallographic experiments. The MTT method was used to determine the cytotoxic activity of five cancer cell lines (Leukemia HL-60, lung cancer A-549, liver cancer SMMC-7721, breast cancer MCF-7, and colon cancer SW480) on the isolated compounds. However, only compound 4 showed moderate cytotoxicity against these cell lines, with IC50 values ranging from 10.28 to 29.70 μM, while the others were inactive. Our chemical investigation also confirmed the absence of jatrophane-type diterpenoids in the species, which may be related to its special habitat.
Carpal valgus angle deviation in thoroughbred foals corrected using single transphyseal screw implant

ABSTRACT The objective of this study was to demonstrate the effectiveness of the single transphyseal screw technique in foals diagnosed with carpal valgus deviation. This study included 22 thoroughbred animals of both sexes, with a mean age of 30 days. All animals had a carpal valgus deviation >5° with irregular development of the distal epiphysis of the radius. All animals were surgically treated to correct the carpal valgus deviation by creating a bridge using a single transphyseal screw. Surgical intervention was performed for 40 limbs, comprising 19 right and 21 left thoracic limbs. This corresponded to four animals with carpal valgus deviation >5° in only one of the limbs and 18 with the deviation in both limbs. It was observed that 38/40 treated limbs (95%) achieved normal angulation according to the literature, i.e., angulation between 0° and 5°. No statistical differences were observed between the affected limbs. The single transphyseal screw technique can be used for the correction of carpal valgus deviation in foals. It is indicated in animals with an average age of 30 days (20-55 days), as its main advantages are rapid application, simple execution, and limited trans- and post-surgical complications, making it an effective procedure in thoroughbred foals with carpal valgus angular deviation.