Miracle-dz/UniFAR-FTUs huggingface dataset:
Well‐Being Therapy as Rehabilitation Therapy for Posttraumatic Stress Disorder Symptoms: A Randomized Controlled Trial

Abstract Many individuals with posttraumatic stress disorder (PTSD) continue to have substantial residual symptoms after completing psychological treatment. Well‐being therapy (WBT) has been developed to treat the residual phase of mental disorders, prevent relapse, and promote a full recovery. The present study aimed to compare treatment as usual (TAU) with the long‐term effects of WBT as a rehabilitation therapy in adults who successfully completed psychological treatment for PTSD. Participants who did not meet PTSD diagnostic criteria after completing treatment were randomized to WBT (n = 29) or TAU (n = 35) groups. Assessments of well‐being, residual PTSD symptoms, and posttraumatic growth were conducted at baseline (T0) and again after 3 months (T1), 6 months (T2), and 1 year (T3). The results of the multilevel analysis revealed that WBT was not more effective than TAU in increasing levels of well‐being, γ = 0.02 (SE = 0.11) or posttraumatic growth, γ = 0.10 (SE = 0.13) nor in decreasing PTSD symptoms, γ = −0.04 (SE = 0.05). However, for participants with low levels of well‐being at baseline (Mental Health Continuum‐Short Form score < 2.6), WBT was more effective than TAU in increasing ratings of well‐being, γ = −0.41 (SE = 0.19) and posttraumatic growth, γ = −0.55 (SE = 0.24); this effect was most evident at T3 for posttraumatic growth, d = 1.23. Future research should assess clinically relevant individual characteristics that to optimize the effectiveness and utility of WBT.
Longevity of the insecticidal effect of three pyrethroid formulations applied to outdoor vegetation on a laboratory-adapted colony of the Southeast Asian malaria vector Anopheles dirus

Outdoor residual spraying is proposed for the control of exophilic mosquitoes. However, the residual effect of insecticide mists applied to outdoor resting habitats of mosquitoes is not well characterized. The objective of this study was to assess the longevity of the residual insecticidal effect of three pyrethroid formulations applied to outdoor vegetation against the Southeast Asian malaria vector Anopheles dirus. Lambda-cyhalothrin capsule suspension, deltamethrin emulsifiable concentrate and bifenthrin wettable powder were sprayed on dense bamboo bushes on the Thailand-Myanmar border during the dry season 2018. The duration and magnitude of the residual insecticidal effect were assessed weekly with a standard cone assay, using freshly collected insecticide-treated bamboo leaves and a laboratory-adapted colony of Anopheles dirus sensu stricto susceptible to pyrethroids. The experiment was repeated during the rainy season to assess the persistence of the lambda-cyhalothrin formulation after natural rains and artificial washings. During the dry season (cumulative rainfall = 28 mm in 111 days), mortality and knockdown (KD) rates were >80% for 60 days with bifenthrin and 90 days with lambda-cyhalothrin and deltamethrin. The 50% knockdown time (TKD50) was <15 min with lambda-cyhalothrin and deltamethrin, and <30 min with bifenthrin. During the rainy season (cumulative rainfall = 465 mm in 51 days), mortality and KD rates were >80% for 42 days and TKD50 was <15 min with lambda-cyhalothrin. Additional artificial washing of the testing material with 10L of tap water before performing the cone tests had no significant effect on the residual insecticidal effect of this formulation. Long-lasting residual insecticidal effect can be obtained when spraying pyrethroid insecticides on the outdoor resting habitats of malaria vectors.
Circulating oxidized LDL, increased in patients with acute myocardial infarction, is accompanied by heavily modified HDL[S]

Oxidized LDL (oxLDL) is a known risk factor for atherogenesis. This study aimed to reveal structural features of oxLDL present in human circulation related to atherosclerosis. When LDL was fractionated on an anion-exchange column, in vivo-oxLDL, detected by the anti-oxidized PC (oxPC) mAb, was recovered in flow-through and electronegative LDL [LDL(−)] fractions. The amount of the electronegative in vivo-oxLDL, namely oxLDL in the LDL(−) fraction, present in patients with acute MI was 3-fold higher than that observed in healthy subjects. Surprisingly, the LDL(−) fraction contained apoA1 in addition to apoB, and HDL-sized particles were observed with transmission electron microscopy. In LDL(−) fractions, acrolein adducts were identified at all lysine residues in apoA1, with only a small number of acrolein-modified residues identified in apoB. The amount of oxPC adducts of apoB was higher in the LDL(−) than in the L1 fraction, as determined using Western blotting. The electronegative in vivo-oxLDL was immunologically purified from the LDL(−) fraction with an anti-oxPC mAb. The majority of PC species were not oxidized, whereas oxPC and lysoPC did not accumulate. Here, we propose that there are two types of in vivo-oxLDL in human circulating plasma and the electronegative in vivo-oxLDL accompanies oxidized HDL.
Discriminative Regularized Auto-Encoder for Early Detection of Knee OsteoArthritis: Data from the Osteoarthritis Initiative

OsteoArthritis (OA) is the most common disorder of the musculoskeletal system and the major cause of reduced mobility among seniors. The visual evaluation of OA still suffers from subjectivity. Recently, Computer-Aided Diagnosis (CAD) systems based on learning methods showed potential for improving knee OA diagnostic accuracy. However, learning discriminative properties can be a challenging task, particularly when dealing with complex data such as X-ray images, typically used for knee OA diagnosis. In this paper, we introduce a Discriminative Regularized Auto Encoder (DRAE) that allows to learn both relevant and discriminative properties that improve the classification performance. More specifically, a penalty term, called discriminative loss is combined with the standard Auto-Encoder training criterion. This additional term aims to force the learned representation to contain discriminative information. Our experimental results on data from the public multicenter OsteoArthritis Initiative (OAI) show that the developed method presents potential results for early knee OA detection.
Clinical and epidemiologic profile of the initial COVID-19 patients at a tertiary care centre in India.

COVID-19 has now become a pandemic. It has spread from Wuhan, China, in December 2019 to a large number of countries within three months. The objective of this work is to report the initial experience with epidemiologic and clinical features, as well as with the management of COVID-19 patients in India. This is a descriptive case series of the first 21 COVID-19 infected patients confirmed with polymerase chain reaction (PCR) and admitted to a tertiary care centre in India from 01.02. 2020 to 19.03. 2020. Clinical, laboratory, and radiologic data were collected, including age, sex, nationality, travel history, symptoms, duration of stay, and comorbidities. The mean age of the population was 40.3 years with a male preponderance. Thirteen (62%) patients had recent travel history outside India in the previous 30 days, two thirds of whom had travelled to Italy. The most common symptoms were fever and cough (42.9%) followed by sore throat, headache and breathlessness. Vital and laboratory parameters were preserved in all patients and none of them required ventilatory support. Among the first 21 patients diagnosed with COVID-19 infection in India, the typical clinical presentation consisted in a mild upper respiratory tract infection predominantly affecting the young male population. One patient required supplemental oxygen. All patients recovered with no residual symptoms. *The Safdarjung Hospital COVID 2019 working group: Nitesh Gupta, Sumita Agrawal, Pranav Ish, Suruchi Mishra, Rajni Gaind, Ganapathy Usha, Balvinder Singh, Manas Kamal Sen, Shibdas Chakrabarti (Consultant and Head, Pulmonary Medicine); NK Gupta (Professor, Pulmonary medicine); Dipak Bhattacharya (Consultant, Pulmonary medicine); Rohit Kumar (Assistant Professor, Pulmonary Medicine); Siddharth R. Yadav (Assistant Professor, Pulmonary Medicine); Rushika Saksena (Specialist, Microbiology); Rojaleen Das (Assistant Professor, Microbiology); Vikramjeet Dutta (Assistant Professor, Microbiology); Anupam Kr Anveshi (Senior Resident, Microbiology); Santvana Kohli (Assistant Professor, Anaesthesiology); Naveen KV (Assistant Professor, Anaesthesiology); Amandeep Jaswal (Assistant Professor, Anaesthesiology).
Diffusion MRI Derived per Area Vessel Density as a Surrogate Biomarker for Detecting Viral Hepatitis B-Induced Liver Fibrosis: A Proof-of-Concept Study

Liver vessel density can be evaluated by an imaging biomarker diffusion-derived vessel density (DDVD): DDVD/area(b0b2) = Sb0/ROIarea0 – Sb2/ROIarea2, where Sb0 and Sb2 refer to the liver signal when b is 0 or 2 (s/mm2); ROIarea0 and ROIarea2 refer to the region of interest (ROI) on b = 0 or 2 images; and Sb2 may be replaced by Sb15 (b = 15). This concept was validated in this study. Liver diffusion images were acquired at 1.5 T. For a scan-rescan repeatability study of six subjects, b values of 0 and 2 were used. The validation study was composed of 26 healthy volunteers and 19 consecutive suspected chronic viral hepatitis B patients, and diffusion images with b values of 0, 2, 15, 20, 30, 45, 50, 60, 80, 100, 200, 300, 600, and 800 were acquired. Four patients did not have liver fibrosis, and the rest were four stage 1, three stage 2, four stage 3, and one stage 4 patients, respectively. The intraclass correlation coefficient for repeatability was 0.994 for DDVD/area(Sb0Sb2) and 0.978 for DDVD/area(Sb0Sb15). In the validation study, DDVD/area(Sb0Sb2) and area(Sb0Sb15) were 14.80 ± 3.06 and 26.58 ± 3.97 for healthy volunteers, 10.51 ± 1.51 and 20.15 ± 2.21 for stage 1–2 fibrosis patients, and 9.42 ± 0.87 and 19.42 ± 1.89 for stage 3–4 fibrosis patients. For 16 patients where IVIM analysis was performed, a combination of DDVD/area, PF, and Dfast achieved the best differentiation for nonfibrotic livers and fibrotic livers. DDVD/area were weakly correlated with PF or Dfast. Both DDVD/area(Sb0Sb2) and area(Sb0Sb15) are useful imaging biomarkers to separate fibrotic and nonfibrotic livers, with fibrotic livers having lower measurements.
Patterns of Sexual Risk Behaviors among College Women: A Latent Profile Analysis

Abstract Sexual risk behavior is common among college women, but little work has identified risk patterns or correlates. The current study utilized latent profile analysis to identify sexual risk patterns among 1,534 college women. Results supported four classes: low sexual risk (68.2%), moderate sexual risk: party hookups (11.0%), moderate sexual risk: risky partners (17.6%), and high sexual risk (3.1%). Membership in the moderate and high-risk classes were associated with coping motives, drinking, and risky peer norms, while membership in the low risk class was associated with sexual satisfaction and low peer approval of risky sex. Implications of the findings are discussed.
Misconceptions surrounding the safety of home birth and hospital birth

Much debate surrounds the topic of women choosing to deliver their infants at home with the services of a midwife. The outcomes of women beginning labor at home, ultimately delivering at home, and the infants born at home were studied in order to determine the safety of home birth among expectant women choosing to be attended by a midwife licensed to practice by the state of Louisiana. Trends associated with those choosing home birth and the frequency of home birth were also analyzed. The study was conducted using retrospective records of clients accepted during the study years 19862000. During the study years, the midwives began care on 284 women. Of those women, 225 delivered at home, 31 were transported to the hospital at some point, 7 voluntarily left the midwife’s care, and 20 were referred out for various reasons. The only cause of infant mortality in the home births was congenital anomalies. There were no maternal deaths or significant maternal morbidity. The years with the largest number of home births were 1997, 1998, and 1999 with 32, 35, and 32 births respectively. During these three years there were three actively practicing midwives, with a fourth serving only six women total. The same three midwives were also practicing in 2000, but the number of home births dropped sharply to 20 due to difficulties attaining physician back-up. Most women who chose home birth had already had a child. Only 20.8% were primiparous. Complications and obstetric procedures were infrequent, outcomes were good, and the breastfeeding rate was 100% with most babies being nursed within one hour of birth. The cesarean section rate for all women who began labor with the intention of delivering at home was 6.2%, much lower than the national cesarean rate which
Early detection treatment response for head and neck carcinomas using intravoxel incoherent motion-magnetic resonance imaging: a meta-analysis.

OBJECTIVES To evaluate the diagnostic accuracy of intravoxel incoherent motion-magnetic resonance imaging (IVIM-MRI) for predicting the treatment response in head and neck squamous cell carcinomas (HNSCC) patients. METHODS A comprehensive literature search was performed to identify original articles on diagnostic performance of IVIM in predicting treatment response in HNSCC patients receiving chemoradiotherapy. The IVIM parameters studied were diffusion coefficient (D), pseudodiffusion coefficient (D*), perfusion fraction (f), and apparent diffusion coefficient (ADC). Summary estimates of diagnostic accuracy were obtained by using a random-effects model. Of 65 studies screened, 8 studies with 347 patients were finally included. RESULTS The pooled sensitivities and specificities were 76% (95% CI 69-82%) and 81% (95% CI 70-89%) for pre-treatment D, and 70% (95% CI 58-80%) and 82% (95% CI 66-92%) for △D, respectively. In addition, the sensitivities and specificities ranged from 41.7 to 94% and 67 to 100% for pre-treatment f, and from 55.7 to 76.5% and 72.2 to 93.3% for pre-treatment ADC, respectively. CONCLUSIONS The diffusion-related coefficients pre-treatment D and △D demonstrated good accuracy in predicting early treatment response in HNSCC patients. However, because of the variability in reference test and other limitations of included literature, further investigation is needed before implementing any IVIM strategy into clinical practice.
Joint Physical Custody and Adolescents' Life Satisfaction in 37 North American and European Countries.

Joint physical custody, a parental care arrangement in which a child lives with each parent about equally after separation or divorce, is an increasingly common phenomenon in many Western countries. Although attention from family scholars, practitioners, and law professionals is growing, there are hardly any numbers on the prevalence of joint physical custody (JPC). Moreover, studies using large-scale representative data on the effects of JPC for children's well-being are still rare. The data for this study come from Health Behaviour in School-Aged Children (HBSC), a representative cross-national survey of adolescents in 37 European and North American countries that was conducted in 2002, 2006, and 2010 and included information on students at the ages of 11, 13, and 15 years (N = 92,886). First, results revealed that symmetrical JPC after family dissolution is still very rare in the majority of countries (5% or less), but reaches 10-20% in some countries. Second, adolescents' life satisfaction in nonintact families is higher in symmetric JPC arrangements than in asymmetric care arrangements. However, after controlling for children and family characteristics, the differences disappear. Thus, it is not the symmetric JPC arrangement that induces adolescents' higher life satisfaction, but rather the children and family characteristics that are associated with the choice of such a custody arrangement by separated or divorced parents.
Three-Dimensional Multiscale Fuzzy Entropy: Validation and Application to Idiopathic Pulmonary Fibrosis

Idiopathic Pulmonary Fibrosis (IPF) is a chronic, severe, and progressive lung disease with short life expectancy. Based on information theory and entropy measurement, a three-dimensional multiscale fuzzy entropy (MFE<inline-formula><tex-math notation="LaTeX">$_{3D}$</tex-math></inline-formula>) algorithm is proposed to identify IPF patients from their computed tomography (CT) volumetric data. First, the validation of the algorithm was performed by analyzing several volumetric synthetic noises (white, blue, brown, and pink), MIX(<italic>p</italic>) processes-based volumes, and texture-based volumes. The entropy values obtained by MFE<inline-formula><tex-math notation="LaTeX">$_{3D}$</tex-math></inline-formula> were consistent with the values obtained using the one, and two-dimensional versions, validating its use in biomedical data. Hence, MFE<inline-formula><tex-math notation="LaTeX">$_{3D}$</tex-math></inline-formula> was applied to CT scans to identify the existence of IPF within two different groups, one of healthy subjects (26) and another of IPF patients (26). Statistical differences were found (p < 0.05) between the entropy values of each group in 5 scale factors out of 10. These results demonstrate that MFE<inline-formula><tex-math notation="LaTeX">$_{3D}$</tex-math></inline-formula> could be an interesting metric to identify IPF in CT scans.
Searching for object pointers in the visual cortex.

We perceive objects as permanent and stable despite frequent occlusions and eye movements, but their representation in the visual cortex is neither permanent nor stable: Feature selective cells respond only as long as objects are visible, and their responses depend on eye position. We explored the hypothesis that the system maintains object pointers that provide permanence and stability. Pointers should send facilitatory signals to the feature cells of an object, and these signals should persist across temporary occlusions and remap to compensate for image displacements caused by saccades. Here we searched for such signals in monkey areas V2 and V4 (Macaca mulatta). We developed a new paradigm in which a monkey freely inspects an array of objects in search for reward while some of the objects are being occluded temporarily by opaque drifting strips. Two types of objects were used to manipulate attention. Results: (1) Eye movements indicated a robust representation of location and type of the occluded objects; (2) in neurons of V4, but not V2, occluded objects produced elevated activity relative to blank condition; (3) the elevation of activity was reduced for objects that had been fixated immediately before the current fixation ('inhibition of return'); (4) when attended, or when target of a saccade, visible objects produced enhanced responses in V4, but occluded objects produced no modulation. While results 1-3 confirm the hypothesis, the absence of modulation under occlusion is not consistent. Further experiments are needed to resolve this discrepancy.
Association of Serum Uromodulin with Death, Cardiovascular Events, and Kidney Failure in CKD.

BACKGROUND AND OBJECTIVES Uromodulin is exclusively produced by tubular epithelial cells and released into urine and serum. Higher serum uromodulin has been associated with lower risk for kidney failure in Chinese patients with CKD and with lower risk for mortality in the elderly and in patients undergoing coronary angiography. We hypothesized that lower serum uromodulin is associated with mortality, cardiovascular events, and kidney failure in white patients with CKD. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS We measured serum uromodulin in 5143 participants enrolled in the German CKD (GCKD) study. The associations of baseline serum uromodulin with all-cause mortality, major adverse cardiovascular events (MACE; a composite of cardiovascular mortality, nonfatal myocardial infarction or stroke, or incident peripheral vascular disease), and kidney failure (dialysis or transplantation) were evaluated using multivariable Cox proportional hazard regression analyses in a cohort study design, adjusting for demographics, eGFR, albuminuria, cardiovascular risk factors, and medication. RESULTS The mean age of participants was 60±12 years, 60% were male. Mean serum uromodulin concentration was 98±60 ng/ml, eGFR was 49±18 ml/min per 1.73 m2, and 78% had eGFR <60 ml/min per 1.73 m2. Participants in lower serum uromodulin quartiles had lower eGFR and higher albuminuria, prevalence of diabetes, hypertension, coronary artery disease, and more frequent history of stroke at baseline. During a follow-up of 4 years, 335 participants died, 417 developed MACE, and 229 developed kidney failure. In multivariable analysis, the highest serum uromodulin quartile was associated with lower hazard for mortality (hazard ratio [HR], 0.57; 95% CI, 0.38 to 0.87), MACE (HR, 0.63; 95% CI, 0.45 to 0.90), and kidney failure (HR, 0.24; 95% CI, 0.10 to 0.55) compared with the lowest quartile. CONCLUSIONS Higher serum uromodulin is independently associated with lower risk for mortality, cardiovascular events, and kidney failure in white patients with CKD. CLINICAL TRIAL REGISTRY NAME AND REGISTRATION NUMBER Deutsches Register für Klinische Studien (DRKS; German national database of clinical studies), DRKS00003971.
Sex-Dependent Effects of Developmental Lead Exposure in Wistar Rats: Evidence from Behavioral and Molecular Correlates

Lead (Pb) exposure in early life affects brain development resulting in cognitive and behavioral deficits. Epidemiologic and experimental evidence of sex as an effect modifier of developmental Pb exposure is emerging. In the present study, we investigated Pb effects on behavior and mechanisms of neuroplasticity in the hippocampus and potential sex differences. To this aim, dams were exposed, from one month pre-mating to offspring weaning, to Pb via drinking water at 5 mg/kg body weight per day. In the offspring of both sexes, the longitudinal assessment of motor, emotional, and cognitive end points was performed. We also evaluated the expression and synaptic distribution of N-methyl-D-Aspartate receptor (NMDA) and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor subunits at post-natal day (pnd) 23 and 70 in the hippocampus. Neonatal motor patterns and explorative behavior in offspring were affected in both sexes. Pb effects in emotional response and memory retention were observed in adult females only, preceded by increased levels of GluN2A and GluA1 subunits at the post-synapse at pnd 23. These data suggest that Pb exposure during development affects glutamatergic receptors distribution at the post-synaptic spine in females. These effects may contribute to alterations in selected behavioral domains.
Magnetic, thermal and martensitic phase transitions in Ni–Co nanoparticles

The nickel-cobalt system is an important alloy in nanotechnology because of its ferromagnetic properties, high thermal stability and shape memory effect. At the nanoscale, its physico-chemical properties become size-, shape- and composition- dependent. However, those properties are still mostly unknown at the nanoscale. Therefore, this manuscript fills this gap in knowledge. Indeed, when the size of the alloy is reduced, the entire phase diagram undergoes a vertical shift downward to lower temperatures, and a tilt caused by a larger size effect affecting cobalt than nickel. Among the most commonly observed shapes, the thermal stability of nickel-cobalt nanoparticles was determined as a function of their size and composition. Furthermore, the ferromagnetic-paramagnetic phase transition and martensitic transformation for those shapes were calculated as a function of the nickel-cobalt alloy composition. As expected, the ferromagnetic and martensitic regions shrunk at the nanoscale; but the martensitic transformation was less affected by size effects compared to magnetic and thermal (melting) transitions.