Miracle-dz/UniFAR-FTUs huggingface dataset:
Antioxidant and cytotoxic activity of Tecoma stans against lung cancer cell line (A549)

Human have been constantly using plants and plant products to overcome many diseases. The antioxidant property of the plant sources is studied to obtain an efficacious drug against cancer. The objectives of the present study is to evaluate the antioxidant and cytotoxic activity of the Tecoma stans extracts against lung cancer cell line in comparison with vincristine drug. The antioxidant activity was studied using the standard DPPH assay and the cytotoxic activity using MTT assay. DPPH assay results show that methanolic extract of T. stans in higher concentration show better antioxidant potential than the standard L-ascorbic acid. They exhibited strong antioxidant potential at 20 µg/mL concentration. The absorbance at 517 nm showed that in the range of 0.201-0.0203 compared to that of absorbance of ascorbic acid at 0.023. Cytotoxic activity was studied using MTT assay which showed that the increase in concentration of extract increases the cell death. At 100µg/mL concentration there is an increased cytotoxic activity, i.e., 99% of cell inhibition. The results of antioxidant and anticancerous activity may be positively correlated.
Tighter Generalization Bounds for Iterative Privacy-Preserving Algorithms

This paper studies the relationship between generalization and privacy preservation of machine learning in two steps. We ﬁrst establish an align-ment between the two facets for any learning algorithm. We prove that ( ε, δ ) -differential privacy implies an on-average generalization bound for a multi-sample-set learning algorithm, which further leads to a high-probability bound for any learning algorithm. We then investigate how the iterative nature shared by most learning algorithms inﬂuences privacy preservation and further generalization. Three composition theorems are proved to approximate the differential privacy of an iterative algorithm through the differential privacy of its every iteration. Integrating the above two steps, we eventually deliver generalization bounds for iterative learning algorithms. Our results are strictly tighter than the existing works. Particularly, our generalization bounds do not rely on the model size which is prohibitively large in deep learning. Experiments of MLP, VGG, and ResNet on MNIST, CIFAR-10, and CIFAR-100 are in full agreement with our theory. The theory applies to a wide spectrum of learning algorithms. In this paper, it is applied to the Gaussian mechanism as an example.
Clinical Pharmacology of Metronidazole in Infants and Children Running title: Metronidazole in infants and children

Metronidazole is active against a wide variety of anaerobic protozoal parasites and anaerobic bacteria. Metronidazole is a prodrug requires reductive activation of the nitro group, has anti-oxidant action, and inhibits DNA replication in susceptible organisms. In preterm infants, the metronidazole dosing consists of a loading dose of 15 mg/kg followed by a maintenance dose of 7.5 mg/kg once-daily. In children, the dose varies according the infection to be treated and ranges from 400 mg thrice-daily to 2 grams oncedaily. The elimination half-life of metronidazole is about 20 hours in infants and about 6 hours in children. This drug is extensively metabolised in humans and the hydroxy-metronidazole is the major metabolite. Metronidazole has been found efficacy and safe but may cause encephalitis and cerebritis in infants and children. Metronidazole interacts with drugs and the interaction with busulfan has been extensively studied. The treatment and the prophylaxis with metronidazole have been reported. This antibiotic penetrates into the cerebrospinal and cured the meningitis caused by Bacteroides fragilis. Metronidazole is transferred across the human placenta and migrates into the breast-milk in significant amounts. The aim of this study is to review the metronidazole dosing, efficacy, safety, effects, pharmacokinetics, metabolism, toxicity, treatment, prophylaxis, penetration into the cerebrospinal fluid, treatment of meningitis, in infants and children, and metronidazole transfer across the human placenta and migration into the breastmilk.
INNOVATION STRATEGIES: AN ANALYSIS IN INFORMATION TECHNOLOGY STARTUPS

Objective : Analyze the main innovation strategies used by information technology startups. Methodology : A qualitative exploratory study was developed, with the evidence interpreted from the content analysis technique. Data collection took place through a semi-structured interview script applied to four managers (founders) of information technology startups, domiciled in the states of Sergipe, Maranhão and Ceará. Main results : The main practices for promoting open innovation identified were partnerships with customers and organizations; and the least found strategy was internationalization. Theoretical / Methodological contributions : This study contributes to the literature on the subject, confirming, through empirical evidence, that open innovation practices adopted by information technology startups are, primarily, partnerships, which follow an informal implementation, through knowledge and the skills offered by the parties involved, to overcome operational deficiencies and obtain specific learning. Another relevant finding was that non-collaboration with institutional actors favors the implementation of incremental innovations. Relevance / Originality : Information technology startups are businesses that are known to be active in bringing innovations to the market. However, studies on innovation strategies in this type of business are still scarce and knowing the nature and ways of implementing these strategies is pertinent, since it can foster better results in innovation.
Analysis of the level of aggression and violence of students and other professional groups who are fans of Düzce sports football

The study aimed to examine the levels of aggression and violence of students and other professional groups who are Düzcespor football fans. For the research model, the survey model, one of the quantitative research types, was chosen. The study's data collection process was carried out during the 2019-2020 season of the Turkey Football Federation, and the population of the study consisted of Düzcespor fans between the ages of 12-68. The sample of the study, on the other hand, consists of 498 people who voluntarily participated in the study using the random sample selection technique. As a result of normality tests (Kolmogorov-Smirnov and Shapiro Wilk), it was determined that the scores obtained from the scales did not show a normal distribution. For this reason, non-parametric tests Mann Whitney-U Test, Kruskal Wallis Test, and Bonferroni Test, one of the Post Hoc tests, were used to determine which group caused the significant difference between the groups as a result of the analysis. Frequency, percentage, minimum, maximum, average, and standard deviation values were also used to analyze the data. The level of significance was determined as p < 0.05. The study's findings showed that Düzcespor supporters had moderate aggression and violent behaviors. There was a significant difference between the variables of gender, age, education level, occupation and income, and aggression and violent behavior. The study results revealed that aggression and tendency to violence are higher in males, younger people, high school students and people with low income.
Multi-task and meta-learning with sparse linear bandits

Motivated by recent developments on meta-learning with linear contextual bandit tasks, we study the beneﬁt of feature learning in both the multi-task and meta-learning settings. We focus on the case that the task weight vectors are jointly sparse , i.e. they share the same small set of predictive features. Starting from previous work on standard linear regression with the group-lasso estimator we provide novel oracle-inequalities for this estimator when samples are collected by a bandit policy. Subsequently, building on a recent lasso-bandit policy, we investigate its group-lasso variant and analyze its regret bound. We specialize the proposed policy to the multi-task and meta-learning settings, demonstrating its theoretical advantage. We also point out a deﬁciency in the state-of-the-art lower bound and observe that our method has a smaller upper bound. Preliminary experiments conﬁrm the effectiveness of our approach in practice.
Substance Abuse, Criminality, and Social Consequences: The Lived Experiences of Male Outpatients in a Methadone Maintenance Treatment Program in Iran

Background: The impact of substance abuse is profound affecting not only the health status of the substance abuse addicts, but also their social networks from family members to social environments. The authors explore the impact of the Methadone Maintenance Treatment (MMT) program on both crime commission and social consequences among individuals struggling with substance dependence in Iran. Methods: The data were collected from 13 male outpatients, ages 26 to 54 years old, using in-depth interviews. These individuals have undergone treatment at the MMT program for six months to nine years at three main methadone-distribution centers in Esfahan, Iran. The descriptive phenomenological method was employed to discern and interpret themes within the data. Results: Thematic analysis revealed four major themes regarding types of crimes related to substance-abuse: 1) crimes against individuals, 2) crimes concerning property, 3) sale and distribution of drugs, and 4) possession of illegal drugs. In addition, three major themes emerged related to substance-abuse social consequences; 1) loss of social trust, 2) social exclusion and marginalization, and 3) loss of family supports. One main theme, return to normal life, was identified for the effect of MMT on patients. Conclusion: The findings show that substance abuse can contribute to criminal behavior and the combination of drug abuse and criminal behavior has a negative impact on the social lives of drug addicts in terms of loss of social and ISSN: 2637-4528 Fatemeh Shafiei1; Mehrdad F Falavarjani2*; Christine J Yeh3; Arash Ghodousi 4 1Faculty of Humanities Science and Law, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran. 2Department of Applied Social Psychology, University of Saskatchewan, Saskatchewan, Canada. 3Department of Counseling Psychology, University of San Francisco, California, United States. 4Forensic Medicine Research Center, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran.
Essential oils and prebiotic on broiler diets as feed additives Óleos essenciais e prebióticos como aditivos em dietas para frangos de corte

The objective of this study was to evaluate the use of a combination of essential oils, prebiotics and antibiotics on broiler production. The treatments consisted of a normal diet meeting the nutritional requirements, and diets with a 5% reduction of nutritional requirements, supplemented or not with antibiotics (En+Sal) (10 g ton-1 enramycin and 125 g ton-1 salinomycin) or a blend of essential oils (EOFOS) (oregano, anise and lemon) plus fructooligosaccharides (125 g ton-1). A total of 1,152 male one-day-old broilers were randomized by weight and distributed into a 2*3 factorial design, consisting of six treatments with each treatment containing eight replicates of 24 birds per experimental unit. The Student-Newman-Keuls test was performed at 5% probability. Broiler performance was evaluated at 10, 21 and 42 days, intestinal morphometry was evaluated at 21 days, microbiological cecum counts at 33 days, blood parameters at 35 days and carcass and cuts yield at 42 days of age. Broilers fed reduced diets had a reduction in performance (P < 0.05). There was an interaction (P < 0.05) between diet type and prebiotics for jejunum villus height and villus height:crypt depth ratios for all intestinal segments. There was no effect (P > 0.05) of growth promoters and diet type on the Lactobacillus and Bifidobacterium populations within the gastrointestinal tract. There were no differences for duodenum or ileum villus heights (P > 0.05). Broilers fed EOFOS showed higher villus height in the jejunum at 21 days. There were no effects on blood parameters of different diets and growth promoters (P > 0.05), nor on carcass and cuts yield, abdominal fat and relative liver weight (P > 0.05). Broilers receiving the normal diet with EOFOS showed higher villus height in the jejunum at 21 days when compared to the normal diet with antibiotics and the normal diet without growth promoters. However, there were no effects of growth promoters and diet type on broiler performance at 42 days.
The Ascent of Bitcoin: Bibliometric Analysis of Bitcoin Research

Blockchain is a path-breaking paradigm, and cryptocurrencies are one of the main application areas of Blockchain technology. Bitcoin leads the cryptocurrency markets, both in terms of market capitalization and in scientific interest. In this paper, we performed a comprehensive bibliometric study of the Bitcoin-related literature. Using the Scopus database, we created a sample that comprises 4495 documents written in the 2011–2020 period. Furthermore, we provided insights about dimensions such as the change in the number of publications over the course of years, the main research areas, types of published documents, most important platforms and sources of Bitcoin publications, highly cited studies, productive authors, author’s countries, and finally main funders of Bitcoin-related research. Lastly, our bibliometric study manifests the current state and future path of Bitcoin literature from distinct perspectives.
Effect of Whole Body Vibration on Balance in Parkinson’s Disease-A Randomized Controlled Pilot Study

Background: Parkinson’s disease is the second most common neurodegenerative disease. The symptoms are treated with medication, physiotherapy, exercise and occupational therapy. The effect of Whole Body Vibration (WBV) as an alternative training method has already been investigated for several symptoms in Parkinson’s patients. Since the effect on the balance does not seem to be clear, the effectiveness of different application frequencies should be tested in this pilot study. Hypothesis: Different frequencies of WBV have different effects on balance parameters. Study design: RCT. Methods: The 54 subjects (37 PD patients, 17 healthy age matched elderly persons) were randomly assigned to a frequency (6, 12 or 18 Hz) or to the control group (only for PD patients). Before and after the treatment of 5 x 60 seconds with a 60 second break each, the measurement on a force plate was performed. Results: Significant differences only were found in 95% ellipse of sway for the condition best of 3 and in anteriorposterior center of pressure displacement. Only the PD 18 Hz group improves in the 95% ellipse of sway. Improvement in anterior-posterior displacement was found for all groups. Conclusions: WBV can cause an increase of the sway area and an improvement anterior-posterior center displacement. Vibration frequency seems to play a subordinate role.
Symbolic Play among Children with Autism Spectrum Disorder: A Scoping Review

Symbolic play is considered an early indicator in the diagnosis of autism spectrum disorder (ASD) and its assessment. The objective of this study was to analyze the difficulties in symbolic play experienced by children with ASD and to determine the existence of differences in symbolic play among children with ASD, children with other neurodevelopmental disorders and children with typical development. A scoping review was carried out in the Web of Science (WoS), Scopus, ERIC, and PsycInfo databases, following the extension for scoping reviews of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. The number of papers included in the review was 22. The results confirm that children with ASD have greater difficulties with symbolic play than children with other neurodevelopmental disorders and children with typical development, even when controlling for their verbal age. Difficulties are greater in situations of free or spontaneous play. Results evidenced that the absence or deficiency in the symbolic play can serve as an early indicator of ASD between the first and second year of life, the developmental moment in which this type of play begins.
Assessment of irisin levels in patients with bipolar depression and unipolar depression

Gamze Erzin1, Rabia Nazik Yüksel2, Miraç Barış Usta3, Canan Topçuoğlu4, Sibel Örsel1 1 Department of Psychiatry, Dışkapı Yıldırım Beyazıt Training and Research Hospital 2 Department of Psychiatry, Ankara City Hospital 3 Department of Child and Adolescent Psychiatry, Ondokuz Mayıs University 4 Department of Biochemistry, Ankara City Hospital, Ankara, Turkey Irisin levels in patients with unipolar and bipolar depression Assessment of irisin levels in patients with bipolar depression and unipolar depression
From modernization to deterritorialization: dynamics and dilemmas of agricultural work in the Cerrado of Piauí, Brazil

O agronegócio tem se manifestado como um dos principais mecanismos de desterritorialização da identidade cultural do agricultor familiar do cerrado piauiense, haja vista que a recente ocupação empresarial do município de Uruçuí, conformada na modernização, nos princípios da agronomia científica e nos procedimentos de gestão administrativa, visando à produção em larga escala, sobretudo, soja, e a conquista de mercados, tem interferido na paisagem, no trabalho, no uso da terra, nos costumes, nos hábitos e nas práticas socioculturais, atingindo o ecossistema e gerando conflitos sociais, como a concentração fundiária, configurando uma grave crise socioambiental. Assim, faz-se necessário questionar o contexto de ocupação do cerrado uruçuiense pelo agronegócio e suas repercussões sobre a continuidade da agricultura familiar. Nesse sentido, salienta-se que este artigo pretende analisar a desterritorialização provocada pelo agronegócio granífero na agricultura familiar de Uruçuí. Este estudo descritivo/explicativo se embasou nos métodos dialético e etnogeográfico, os quais foram subsidiados por pesquisas bibliográfica, documental e levantamento, como também por formulários semiestruturados aplicados entre 254 agricultores familiares de Uruçuí. Concluiu-se que o processo de desterritorialização em Uruçuí, ocasionado pela difusão do agronegócio granífero, confirmou-se, mormente, na subordinação da mão de obra familiar ao trabalho temporário nas grandes propriedades agrícolas, pois a mesma era desvalorizada, apresentando baixo nível de especialização e reduzida remuneração salarial; na diminuição das relações de ajuda mútua entre as comunidades rurais; em mudanças nos modos de vida; e na eminente dependência dos agricultores familiares à aplicação idílica de insumos químicos nas lavouras.
Medical Noncompliance in a Pediatric Patient Living in a Single-Parent Household

Noncompliance is a patient’s inability to comply with the recommended treatment for their complete recovery from an ailment, while compliance is the extent to which a patient adheres to the provider’s directive, such as medication and orders given. The purpose of this study was to determine if motivational interviewing when applied to noncompliant pediatric patients from single-parent households, would improve global medical compliance in this population as compared to the standard of care at the end of three months. Thirty-two participants were recruited using the homogeneous purposeful sampling. The project employed a mixed-method approach. Fred Kleinsinger’s noncompliant behavior tool was administered to obtain staging data on noncompliance among participants. Pretest and posttest data were inputted to a Microsoft Excel spreadsheet and subsequently imported into SPSS version 25 software. The demographic data were analyzed using descriptive statistics. Pretest and posttest data were compared using a paired t test and Wilcoxon’s signed-rank test. Following motivational interviewing, median noncompliance decreased from a score of 2 preintervention to 1 postintervention. Findings from other studies suggest that motivational interviewing is effective in curbing or reducing noncompliance. In this project, the goal of implementation scientific research was met by the conclusion that motivational interviewing significantly decreased medical noncompliance among pediatric patients from single-parent families. Healthcare providers must screen for potential noncompliance and prevent it before it manifests by proactively implementing a process for addressing noncompliance in their clinics.
Search for an association between neutrinos and radio-selected blazars with ANTARES

Recently, evidence for an association between high energy neutrinos detected by IceCube and radio-selected blazars has been found by Plavin et al.(2020, 2021). This result was achieved using an all sky complete sample of 3411 blazars selected on their parsec-scale flux density at 8 GHz higher than 150 mJy. We perform a positional correlation analysis using the same sample of radioselected blazars, with the latest point source sample of neutrinos extracted from the data collected by the ANTARES detector between January 29, 2007 and February 28, 2020. Preliminary results are presented and discussed.
Formulation and Evaluation of Desonide Loaded Microemulsion Based Gel for Management of Atopic Dermatitis

Objective: The aim of the current study was to formulate and evaluate desonide loaded microemulsion gel for effective management of Atopic Dermatitis (AD). Methods: Microemulsions (MEs) were developed and optimized using D-optimal mixture statistical experimental design. The morphology of ME was studied using transmission electron microscopy. To improve skin retention of formulation, gelling of the optimized ME was carried out using Carbopol 940 (1% w/w). The efficacy of the formulation was evaluated on mice with dinitrochloro benzene induced dermatitis. Results: The ME formulation containing 5% w/w oil, 35.643% w/w Smix, and 59.357% w/w water was selected. The physicochemical characterstics exihibited by developed ME were found to be optimal. Ex vivo studies showed 3 fold increase in drug retention from MG in rat skin as compared to commercial formulation. MG resulted in significant reduction (p<0.05) in dermatitis score as compared to marketed gel with reduction in neutrophilic infilteration. Transepidermal water loss by application of drug loaded carbopol gel, marketed gel and MG on mice skin was found to be 3.01 ± 0.08 g/m2h, 2.12 ± 0.06 g/m2h and 2.52 ± 0.12 g/m2h, respectively. The significant reduction in transepidermal water loss (p<0.05) indicated the potential of MG to minimize steroid associated epidermal barrier impairment due to entrapment of drug in ME droplets. Conclusion: The overall results elucidated that desonide loaded MG could be a successful carrier system for the treatment of AD.