Miracle-dz/UniFAR-FTUs huggingface dataset:
Divergence of Liver Lipidomes in Tibetan and Yorkshire Pigs Living at Different Altitudes

The Tibetan pig is a characteristic breed of the Qinghai-Tibet Plateau with distinct physiological and meat quality attributes. The liver lipid profile can offer an important perspective to explore the uniqueness of Tibetan pigs. A quantitative comparison of liver lipidomes revealed significant differences in the lipid profiles between Tibetan and Yorkshire pigs raised at different altitudes. The abundance of lipids in the livers of pigs raised at a high altitude was higher than that of pigs raised at a lower altitude, whereas the abundance of lipids in the livers of Yorkshire pigs was higher than that of Tibetan pigs raised at the same altitude. Of the 1101 lipids identified, 323 and 193 differentially abundant lipids (DALs) were identified in the pairwise comparisons of Tibetan and Yorkshire pigs raised at different altitudes, respectively. The DALs of Tibetan pigs consisted mainly of 161 triglycerides, along with several acylcarnitines, represented by carnitine C2:0, and significant changes in the abundance of some phospholipids. The DALs of Yorkshire pigs were more complex, with significant increases in the abundance of triglycerides, cholesteryl esters, and free fatty acids, and decreases in the abundance of some phospholipids. This research provides strong theoretical and data support for the high-quality development of the highland livestock industry.
Spin-valve transistor formed on GaAs[001] substrate

A spin-valve transistor with an epitaxial Fe/Au/Fe [001] base was formed on nGaAs, of which the transfer ratio was 10/sup -3/ at 3 V with more than 100% magnetocurrent ratio. Both bottom and upper Fe layers show the uniaxial anisotropy with easy magnetization axis along [110], although the contribution of cubic anisotropy with [100] easy axis cannot be neglected for the upper Fe layer. Possibility of applying spin-valve transistors to read heads in the high-density magnetic recording is discussed.
Effects of the induction field on the Sq dynamo currents in the ionosphere

[1] Effects of the induction field on the ionospheric currents generated by the Sq dynamo were studied using current function. It was shown that the induction field significantly affects the ionospheric currents only if the field is artificially enhanced by 100 times. Existence of the spherical inner conductor reduces the effects because currents induced in the sphere partly cancel vertical component of the variation field. On the other hand, it is probable that the induction field should be considered for the simulation of the ionospheric current with the period of less than 10 min. because the induction field affects the ionospheric Sq currents if the field is enhanced by 100 times.
On the evolution of roll waves

An amplitude evolution equation is derived for roll waves that occur in a uniform open-channel flow down an incline. A periodic series of roll waves, which is a manifestation of the instability of high-velocity turbulent flow, is shown to be itself unstable to subharmonic disturbances. These disturbances develop into longer and higher roll waves. In this way roll waves tend to increase in size as time goes on, in agreement with experimental evidence.
Molecular Basis of Plant Profilins’ Cross-Reactivity

Profilins are ubiquitous allergens with conserved structural elements. Exposure to profilins from different sources leads to IgE-cross-reactivity and the pollen–latex–food syndrome. Monoclonal antibodies (mAbs) that cross-react with plant profilins and block IgE-profilin interactions are relevant for diagnosis, epitope mapping, and specific immunotherapy. We generated IgGs mAbs, 1B4, and 2D10, against latex profilin (anti-rHev b 8) that inhibit the interaction of IgE and IgG4 antibodies from sera of latex- and maize-allergic patients by 90% and 40%, respectively. In this study, we evaluated 1B4 and 2D10 recognition towards different plant profilins, and mAbs recognition of rZea m 12 mutants by ELISAs. Interestingly, 2D10 highly recognized rArt v 4.0101 and rAmb a 8.0101, and to a lesser extent rBet v 2.0101, and rFra e 2.2, while 1B4 showed recognition for rPhl p 12.0101 and rAmb a 8.0101. We demonstrated that residue D130 at the α-helix 3 in profilins, which is part of the Hev b 8 IgE epitope, is essential for the 2D10 recognition. The structural analysis suggests that the profilins containing E130 (rPhl p 12.0101, rFra e 2.2, and rZea m 12.0105) show less binding with 2D10. The distribution of negative charges on the profilins’ surfaces at the α-helices 1 and 3 is relevant for the 2D10 recognition, and that may be relevant to explain profilins’ IgE cross-reactivity.
Characteristics of a sensitive micro-Hall probe fabricated on chemical vapor deposited graphene over the temperature range from liquid-helium to room temperature

We have investigated the transport and noise properties of a micron-sized Hall probe, fabricated on chemical vapor deposited (CVD) graphene, from 300 K to 4.2 K. The field sensitivity of the Hall probe was tunable within ∼0.031-0.12 Ω/G, while the field resolution could reach ∼0.43-0.09 G/Hz1/2 at room temperature. The characteristics of graphene Hall probes (GHPs) were found to be comparable to present Hall sensors. Our results indicate that the fundamental limitation of the field sensitivity and the field resolution are respectively restricted by intrinsic and extrinsic defects. Our study paves the way for the use of CVD GHPs for scanning Hall probe with high field sensitivity and submicron spatial resolution at room temperature.
Kaurane-Type Diterpenoids as Potential Inhibitors of Dihydrofolate Reductase-Thymidylate Synthase in New World Leishmania Species

The bifunctional enzyme Dihydrofolate reductase-thymidylate synthase (DHFR-TS) plays a crucial role in the survival of the Leishmania parasite, as folates are essential cofactors for purine and pyrimidine nucleotide biosynthesis. However, DHFR inhibitors are largely ineffective in controlling trypanosomatid infections, largely due to the presence of Pteridine reductase 1 (PTR1). Therefore, the search for structures with dual inhibitory activity against PTR1/DHFR-TS is crucial in the development of new anti-Leishmania chemotherapies. In this research, using the Leishmania major DHFR-TS recombinant protein, enzymatic inhibitory assays were performed on four kauranes and two derivatives that had been previously tested against LmPTR1. The structure 302 (6.3 µM) and its derivative 302a (4.5 µM) showed the lowest IC50 values among the evaluated molecules. To evaluate the mechanism of action of these structures, molecular docking calculations and molecular dynamics simulations were performed using a DHFR-TS hybrid model. Results showed that hydrogen bond interactions are critical for the inhibitory activity against LmDHFR-TS, as well as the presence of the p-hydroxyl group of the phenylpropanoid moiety of 302a. Finally, additional computational studies were performed on DHFR-TS structures from Leishmania species that cause cutaneous and mucocutaneous leishmaniasis in the New World (L. braziliensis, L. panamensis, and L. amazonensis) to explore the targeting potential of these kauranes in these species. It was demonstrated that structures 302 and 302a are multi-Leishmania species compounds with dual DHFR-TS/PTR1 inhibitory activity.
Modal Logics with Existential Modality, Finite-iteration Modality, and Intuitionistic Base: Decidability and Completeness

This thesis investigates some modal logics that have been found to be useful in modelling computational phenomena and, therefore, of interest to theoretical computer science—namely, modal intuitionistic logics, logics with finite-iteration modality, and logics with existential modality. We prove a number of new general results concerning these logics. In particular, in chapter 3, we prove a general decidability result for intuitionistic modal logics through embedding them into the two-variable monadic second-order guarded fragment GF 2 mon with certain conditions imposed on relations occurring in GF 2 mon-formulas. In chapter 4, we prove the analogue of Makinson theorem for logics with finite-iteration modality, that is that every consistent logic in this language is either a sublogic of the logic of a Kripke frame containing a single reflexive point or a sublogic of the logic of a Kripke frame containing a single irreflexive point; the by-product of the theorem is the decidability of the problem of consistency for effectively finitely axiomatizable logics with finite-iteration modality. In chapter 5, we prove completeness of Hilbert-style axiomatizations of three logics whose language contains an existential modality 〈#〉: the minimal normal logic with 〈#〉, K#; its deterministic extension DK#; and the logic that is CPDL (converse PDL) with a single nominal and 〈#〉 (this logic is known from the literature as PDL). Apart from the presentation of the above-mentioned results, the thesis contains, in chapter 2, an overview of background material on modal logics and guarded fragments; this overview can also be read as a concise survey of the field of guarded fragments.
Evaluation of Scrotal Pathologies by Ultrasound and Color Doppler

Introduction Due to its ease of use, lack of ionizing radiation exposure, noninvasive nature, reproducibility, low cost, and ease of accessibility, ultrasound (US) is the preferred imaging modality for evaluating scrotal disease. High-resolution US and color Doppler better highlight scrotal and testicular diseases because of the scrotum's superficial anatomy. The genital organs are subjected to damaging ionizing radiation during CT, while MRI is both costly and uncommon. Aims and objectives The aim of this study is to use ultrasonography (USG) to examine various scrotal diseases and to diagnose and identify different disorders utilizing high-resolution US and color Doppler. Materials and methods The study was done on 60 patients who were referred to the Department of Radiodiagnosis by the General Surgery and Urology departments for the scrotal US and Doppler study. This study was conducted between October 2021 and March 2022 at the Indira Gandhi Institute of Medical Sciences, Patna, India. Results Out of 60 patients, hydrocele was seen in 25 cases, scrotal hernia in 12 cases, undescended testis in eight cases, varicocele and epididymal cysts in seven cases, etc. In acutely painful scrotal disorders, high-frequency US with color Doppler sonography successfully distinguishes between testicular ischemia/torsion and acute inflammatory illnesses. Eighteen cases of inflammatory scrotal pathologies and one case of testicular torsion were seen. Conclusion In detecting and assessing scrotal diseases, high-frequency USG and color Doppler sonography have good sensitivity and specificity. Furthermore, the lack of ionizing radiation, simplicity, wide availability, cost-efficiency, and reproducibility make it a highly important method for scrotal diseases.
Evaluation of Changes in Some Functional Properties of Human Mesenchymal Stromal Cells Induced by Low Doses of Ionizing Radiation

Each person is inevitably exposed to low doses of ionizing radiation (LDIR) throughout their life. The research results of LDIR effects are ambiguous and an accurate assessment of the risks associated with the influence of LDIR is an important task. Mesenchymal stromal cells (MSCs) are the regenerative reserve of an adult organism; because of this, they are a promising model for studying the effects of LDIR. The qualitative and quantitative changes in their characteristics can also be considered promising criteria for assessing the risks of LDIR exposure. The MSCs from human connective gingiva tissue (hG-MSCs) were irradiated at doses of 50, 100, 250, and 1000 mGy by the X-ray unit RUST-M1 (Russia). The cells were cultured continuously for 64 days after irradiation. During the study, we evaluated the secretory profile of hG-MSCs (IL-10, IDO, IL-6, IL-8, VEGF-A) using an ELISA test, the immunophenotype (CD45, CD34, CD90, CD105, CD73, HLA-DR, CD44) using flow cytometry, and the proliferative activity using the xCelligence RTCA cell analyzer at the chosen time points. The results of study have indicated the development of stimulating effects in the early stages of cultivation after irradiation using low doses of X-ray radiation. On the contrary, the effects of the low doses were comparable with the effects of medium doses of X-ray radiation in the long-term periods of cultivation after irradiation and have indicated the inhibition of the functional activity of MSCs.
On the linear stability of channel flow over riblets

In the present study channel flow with the lower wall mounted with streamwise riblets is considered. The laminar flow state is computed and its stability is investigated by superimposing infinitesimal perturbations, which leads to a hydrodynamic stability problem in a complex geometry. Linear stability characteristics for riblets with several scalloped cross sections are computed. The computations show that at the primary instability level the laminar flow in the presence of riblets is more unstable than channel flow with smooth walls.
Metabolic Consequences of the Water We Drink: A Study Based on Field Evidence and Animal Model Experimentation

The effect of the chronic consumption of water contaminated with residual concentrations of DDT’s metabolites (DDD—dichlorodiphenyldichloroethane and DDE—dichlorodiphenyldichloroethylene) found in the environment were evaluated on the biometric, hematological and antioxidant system parameters of the hepatic, muscular, renal and nervous tissues of Wistar rats. The results showed that the studied concentrations (0.002 mg.L−1 of DDD plus 0.005 mg.L−1 of DDE) could not cause significant changes in the hematological parameters. However, the tissues showed significant alteration in the activity of the antioxidant system represented by the increase in the activity of the enzymes gluthathione S-transferases in the liver, superoxide dismutase in the kidney, gluthathione peroxidase in the brain, and several changes in enzymatic activity in muscle (SOD, GPx and LPO). The enzymes alanine aminotransaminase (ALT) and aspartate aminotransaminase (AST) were also evaluated for the amino acids’ metabolism in the liver, with ALT showing a significant increase in the exposed animals. In the integrative analysis of biomarkers (Permanova and PCOA), the studied concentrations showed possible metabolic changes and damage to cellular structures evidenced by increased oxidative stress and body weight gain among the treated animals. This study highlights the need for further studies on the impact of banned pesticides still present in soils that may induce adverse effects in organisms that may prevail in future generations and the environment.
Concepts for near-field interferometers with large molecules

We study the theory behind a Talbot–Lau interferometer. This consists of three gratings in each other’s Fresnel near field and accepts spatially incoherent illumination. Our formalism gives a clear physical picture and permits efficient numerical simulations. We concentrate on the case of matter waves and provide an adequate description of recent fullerene experiments taking into account the Casimir–Polder interaction between a molecular beam and mechanical gratings. For more massive molecules, the influence of this interaction is more drastic and leads to a forbiddingly narrow velocity distribution requirement for future experiments with very massive molecules. This problem can be avoided by configurations where at least one mechanical grating is replaced with an optical grating, i.e. a standing light wave. Such interferometers show improved scaling behaviour. Magnifying or demagnifying interferometer variants are also discussed.
New results on the massive star-forming region S106 by BEAR spectro-imagery

As a typical example of interaction of a massive star with its parent cloud, the close environment of S106 IR in the star-forming region S106 was observed at high spectral resolution (~16 km s -1 ). Integral field spectroscopy with BEAR, an imaging Fourier Transform Spectrometer (FTS), on a field of ~40´´in diameter, in the H 2 1–0 S (1), 2–1 S (1), Br γ , $\ion{He}{i}$ and [$\ion{Fe}{iii}$] lines. From the data several maps were obtained: intensity, velocity and linewidth in the Br γ and the H 2 1–0 S (1) line, 1–0 S (1)/2–1 S (1) line ratio, and continuum emission at 2.1 μ m. From the latter, about twenty low-mass stars were detected with photometry in this band, and an estimate of their mass was made leading to the conclusion that S106 is a site of formation of mainly sub-solar mass stars. The intensity structure of the excited molecular gas H 2 was found to be clumpy while the velocity is almost uniformely at $v_{{\rm LSR}}$ $\simeq$ 1.5 km s -1 except to the south where the velocity reaches up to 15 km s -1 in a zone limited by the long edge of a rectangular hole in the emission. The H 2 line ratio map with values from 1 to 9 implies that UV-absorption and shocks are participating in the excitation process. A PDR model with a temperature of 3700 K for S106 IR was used to retrieve the H 2 gas density and temperature. The density was found to vary between 1 and 3.5 $\times$ 10 5 cm -3 with corresponding temperatures between 660 and 1240 K. The study of the linewidth distribution indicates for most of the gas a supersonic turbulence with a mean contribution to the observed profiles of ≥ 6 km s -1 . Turbulence is likely to be responsible for the observed clumpy structure of the excited gas. Point-like spots with a linewidth as high as 30 km s -1 in one position are detected, which may be vortices in the molecular gas. The $\ion{H}{ii}$ region probed by Br γ shows a broad range of velocity, from -45 to +80 km s -1 , organized in velocity structures that correspond to two pairs of large, bipolar outflows originating from the massive source, not directed along the axis of the $\ion{H}{ii}$ region. Emission lines of $\ion{He}{i}$ and [$\ion{Fe}{iii}$] are detected in a bright area to the southwest of S106 IR, with point-like structures suggesting photoevaporating clumps. From the velocity data, a 3-D model of the environment of S106 IR is proposed. S106 is an example of an evolved $\ion{H}{ii}$ region seen face-on. The central source located at the edge of its parent molecular cloud has carved an expanding cylinder of turbulent, atomic gas of $\simeq$0.1 pc in radius. This massive object was formed by an accretion disk process. The disk is still present and the bipolar outflows are remnants of the massive star activity. A time scale of 1400 yr is estimated for the most recent event. A thin and quiescent clumpy layer of warm H 2 marks the transition of the $\ion{H}{ii}$ region to the molecular cloud. From the data, there are locally no signs of ongoing star formation.
A Review of Clinical and Preclinical Studies on the Therapeutic Potential of Black Seeds (Nigella sativa) in the Management of Polycystic Ovarian Syndrome (PCOS)

Objectives Polycystic ovary syndrome (PCOS) is a condition that occurs frequently among women of reproductive age and is a polygenic, multifactorial, endocrine, and metabolic disorder. PCOS is becoming more common as a result of risk factors such as current lifestyle, overnutrition, and stress. The use of traditional herbal medicine is higher among the global population. Hence, this review article focuses on the potential of Nigella sativa to manage women with PCOS. Methods A literature search was carried out using databases including Medline, Google Scholar, EBSCO, Embase, and Science Direct, as well as reference lists, to identify relevant publications that support the use of N. sativa in the management of women with PCOS. Results Several clinical and preclinical studies have demonstrated that the major bioactive constituent of black seed (N. sativa), thymoquinone, has potential for managing women with PCOS. Moreover, N. sativa may help to manage oligomenorrhea and amenorrhea in women with PCOS through its anti-inflammatory and antioxidant properties. Conclusion N. sativa has potential for use as a herbal medicine for managing women with PCOS as an integrative medicine along with traditional and modern medicine in conjunction with calorie restriction and regular exercise.
Wall turbulence manipulation by large-scale streamwise vortices

This paper describes an experimental study of the manipulation of a fully developed turbulent channel flow through large-scale streamwise vortices originated by vortex generator jets distributed along the wall in the spanwise direction. Apart from the interest in flow management itself, an important aim of the research is to observe the response of the flow to external perturbations as a technique for investigating the structure of turbulence. Considerable mean and fluctuating skin friction reductions, locally as high as 30% and 50% respectively, were measured for an optimal forcing flow intensity. Mean and fluctuating velocity profiles are also greatly modified by the manipulating large-scale vortices; in particular, attenuation of the turbulence intensity was measured. Moreover the flow manipulation caused an increase in longitudinal coherence of the wall organized motions, accompanied by a reduced frequency of burst events, demonstrated by a reduction of the velocity time derivative PDFs and by an higher intermittency. A strong transversal periodic organization of the flow field was observed, including some typical behaviours in each of the periodic boxes originated by the interaction of the vortex pairs. Results are interpreted and discussed in terms of management of the near-wall turbulent structures and with reference to the wall turbulence regeneration mechanisms suggested in the literature.
Some Convexity Features Associated with Unitary Orbits

Abstract Let ${{\mathcal{H}}_{n}}$ be the real linear space of $n\,\times \,n$ complex Hermitian matrices. The unitary (similarity) orbit $\mathcal{U}\left( C \right)$ of $C\,\in \,{{\mathcal{H}}_{n}}$ is the collection of all matrices unitarily similar to $C$ . We characterize those $C\,\in \,{{\mathcal{H}}_{n}}$ such that every matrix in the convex hull of $\mathcal{U}\left( C \right)$ can be written as the average of two matrices in $\mathcal{U}\left( C \right)$ . The result is used to study spectral properties of submatrices of matrices in $\mathcal{U}\left( C \right)$ , the convexity of images of $\mathcal{U}\left( C \right)$ under linear transformations, and some related questions concerning the joint $C$ -numerical range of Hermitian matrices. Analogous results on real symmetric matrices are also discussed.
Alteration of Physical Attributes and Production in Fertigated Soil With Swine Effluent

Purpose: The objective of this study was to evaluate the effects of the use of different swine wastewater (ARS) in electrical (CEes) and hydraulic (K0) conductivity in soil grown with tomato, as well as in tomato yeld. Method/design/approach: The literature review showed that studies have been based on the application of residues replacing evapotranspirometric demand, causing deleterious effects to soil and plants. Results and conclusion: the mineral fertilization was more effective in the ionization of the soil solution than the ARS, presenting higher values of Cees in relation to the treatments that receive smaller ARS slides and the K0 increased due to the contribution of salts and organic matter, resulting from mineral fertilization, irrigation and fertigation with ARS, which caused soil restructuring Research implications: main managerial, academic, and/or social contributions of the research. Originality/value: This study applies ARS slides based on nitrogen doses, as it is element in higher relative concentration, seeking to determine contents that may indicate higher ARS consumption and higher production.