Miracle-dz/UniFAR-FTUs huggingface dataset:
An Attention-Based CoT-ResNet With Channel Shuffle Mechanism for Classification of Alzheimer’s Disease Levels

Detection of early morphological changes in the brain and early diagnosis are important for Alzheimer’s disease (AD), and high-resolution magnetic resonance imaging (MRI) can be used to help diagnose and predict the disease. In this paper, we proposed two improved ResNet algorithms that introduced the Contextual Transformer (CoT) module, group convolution, and Channel Shuffle mechanism into the traditional ResNet residual blocks. The CoT module is used to replace the 3 × 3 convolution in the residual block to enhance the feature extraction capability of the residual block, while the Channel Shuffle mechanism is used to reorganize the feature maps of different groups in the input layer to improve the communication between the feature maps from different groups. Images of 503 subjects, including 116 healthy controls (HC), 187 subjects with mild cognitive impairment (MCI), and 200 subjects with AD, were selected and collated from the ADNI database, and then, the data were pre-processed and sliced. After that, 10,060 slices were obtained and the three groups of AD, MCI and HC were classified using the improved algorithms. The experiments showed that the refined ResNet-18-based algorithm improved the top-1 accuracy by 2.06%, 0.33%, 1.82%, and 1.52% over the traditional ResNet-18 algorithm for four medical image classification tasks, namely AD: MCI, AD: HC, MCI: HC, and AD: MCI: HC, respectively. The enhanced ResNet-50-based algorithm improved the top-1 accuracy by 1.02%, 2.92%, 3.30%, and 1.31%, respectively, over the traditional ResNet-50 algorithm in four medical image classification tasks, demonstrating the effectiveness of the CoT module replacement and the inclusion of the channel shuffling mechanism, as well as the competitiveness of the improved algorithms.
Diabetic Foot Risk Classification at the Time of Type 2 Diabetes Diagnosis and Subsequent Risk of Mortality: A Population-Based Cohort Study

Aim We aimed to compare the mortality of individuals at low, moderate, and high risk of diabetic foot disease (DFD) in the context of newly diagnosed type 2 diabetes, before developing active diabetic foot problem. Methods This was a population-based cohort study of adults with newly diagnosed type 2 diabetes utilizing IQVIA Medical Research Data. The outcome was all-cause mortality among individuals with low, moderate, and high risk of DFD, and also in those with no record of foot assessment and those who declined foot examination. Results Of 225,787 individuals with newly diagnosed type 2 diabetes, 34,061 (15.1%) died during the study period from January 1, 2000 to December 31, 2019. Moderate risk and high risk of DFD were associated with increased mortality risk compared to low risk of DFD (adjusted hazard ratio [aHR] 1.50, 95% CI 1.42, 1.58; aHR 2.01, 95% CI 1.84, 2.20, respectively). Individuals who declined foot examination or who had no record also had increased mortality risk of 75% and 25% vs. those at low risk of DFD, respectively (aHR 1.75, 95% CI 1.51, 2.04; aHR 1.25, 95% CI 1.20, 1.30). Conclusion Individuals with new-onset type 2 diabetes who had moderate to high risk of DFD were more likely to die compared to those at low risk of DFD. The associations between declined foot examination and absence of foot examinations, and increased risk of mortality further highlight the importance of assessing foot risk as it identifies not only patients at risk of diabetic foot ulceration but also mortality.
Peripheral Microangiopathy Changes in Pulmonary Arterial Hypertension Related to Systemic Sclerosis: Data From a Multicenter Observational Study

Systemic sclerosis (SSc) is a connective tissue disease characterized by immune-system alterations, fibrosis involving the skin and internal organs and diffuse microangiopathy. Pulmonary arterial hypertension (PAH) is a severe complication of SSc affecting about 10–15% of the patients and it is a leading cause of mortality. Due to the devastating nature of SSc-PAH, there is a clear need to systematically adopt appropriate screening programs. Nail fold videocapillaroscopy (NVC) studies have shown a more severe peripheral microvascular dysfunction in SSc patients with PAH suggesting that abnormalities in peripheral microcirculation may correlate with pulmonary microangiopathy. This is a cross-sectional study involving four tertiary University Rheumatology Units in the Center-North of Italy. Seventy patients, 35 adults with SSc and PAH confirmed by RHC (F/M 34/1; median age 65.2 ± 8.9 SD yrs), and 35 SSc patients without PAH were enrolled (F/M 3471; median age 63.3 ± 10.3 SD yrs). Clinical, laboratoristic and instrumental data were collected and NVC was performed in all patient. Specific NVC parameters were evaluated and a semi-quantitative rating scale was adopted to score these changes. Finally, patients were distributed into the suitable NVC pattern belonging to the scleroderma pattern. Our aim was to compare the peripheral microangiopathy changes in SSc patients with and without PAH, and to investigate the relationship between NVC findings and the main hemodynamic parameters of pulmonary vasculopathy. Patients with SSc-PAH+ showed a significant higher frequency of interstitial lung disease (ILD). No significant differences regarding clinical and laboratoristic parameters were observed. NVC abnormalities, avascular areas were more frequent in SSc patients with PAH, respect to those without (p = 0.03), and capillary density was significantly lower when considering grade 3 (p = 0.02). A higher NVC semiquantitative mean was found in SSc-PAH+ patients and a greater rate of the “late” pattern was detected in SSc-PAH+ subjects in respect to PAH- (57.1% vs. 25.7%) (p = 0.03). A significant correlations between pulmonary pressure values (sPAP by TTE and mPAP by RHC) and the capillary density (Spearman's rho 0.35, p = 0.04 for both). Our findings provide additional evidence to the literature data, confirming that a higher degree of peripheral nailfold microangiopathy is more common in SSc-PAH patients, and further strengthening the concept that NVC changes may run parallel with similar abnormalities inside pulmonary microcirculation.
Research Progress on the NSP9 Protein of Porcine Reproductive and Respiratory Syndrome Virus

Porcine reproductive and respiratory syndrome (PRRS) is a contagious disease caused by the porcine reproductive and respiratory syndrome virus (PRRSV). PRRS is also called “blue ear disease” because of the characteristic blue ear in infected sows and piglets. Its main clinical features are reproductive disorders of sows, breathing difficulties in piglets, and fattening in pigs, which cause considerable losses to the swine industry. NSP9, a non-structural protein of PRRSV, plays a vital role in PRRSV replication and virulence because of its RNA-dependent RNA polymerase (RdRp) structure. The NSP9 sequence is highly conserved and contains T cell epitopes, which are beneficial for the development of future vaccines. NSP9 acts as the protein interaction hub between virus and host during PRRSV infection, especially in RNA replication and transcription. Herein, we comprehensively review the application of NSP9 in terms of genetic evolution analysis, interaction with host proteins that affect virus replication, interaction with other viral proteins, pathogenicity, regulation of cellular immune response, antiviral drugs, vaccines, and detection methods. This review can therefore provide innovative ideas and strategies for PRRSV prevention and control.
The Impacts of Climate Change on Land Hydroclimatology of the Laurentian Great Lakes Basin

The freshwater resources of the Laurentian Great Lakes basin contribute significantly to the environment and economy of the region. With the impacts of climate change becoming more evident, sustainable management of the freshwater resources of the Laurentian Great Lakes basin is important. This study uses 36 simulations from 6 regional climate models to quantify trends and changes in land-area precipitation and temperature in two future periods (mid-century, 2035–2064 and end-century, 2065–2094) with reference to a baseline period (1951–2005) for two emission scenarios (RCP4.5 and RCP 8.5). Climatic forcings from these 36 simulations are used as input to a calibrated and validated hydrological model to assess changes in land snowpack and actual evapotranspiration, and runoff to lake. Ensemble results show wetter (7 to 15% increase in annual precipitation) and warmer (2.4–5.0°C increase in annual mean temperature) future conditions on GL land areas. Seasonal and monthly changes in precipitation and mean temperature are more sporadic, for instance although precipitation is projected to increase overall, in some scenarios, summer precipitation is expected to decrease. Projected increases in highest one-day precipitation and decreases in number of wet days indicate possible increases in extreme precipitation in future. Minimum temperature is expected to increase in a higher rate than maximum temperature. Ensemble results from the hydrological model show projected decrease in snowpack (29–58%). Similarly, actual evapotranspiration is projected to increase, especially during summer months (up to 0.4 mm/day). Annually, runoff is expected to increase (up to 48% in Superior, 40% in Michigan-Huron, 25% Erie and 28% in Ontario). Seasonal and monthly changes in runoff are more sporadic (e.g., projected decrease up to 17% in Erie subdomain in October). Such contrasting patterns of changes in land hydroclimatology of the GL basin will pose challenges to sustainable management of the water resources of the basin in future.
Maternal Mental Health in Late Pregnancy and Longitudinal Changes in Postpartum Serum Vitamin B-12, Homocysteine, and Milk B-12 Concentration Among Brazilian Women

Background Little is known regarding the association between mental health distress during pregnancy and postpartum maternal serum biomarkers of vitamin B-12 status and milk B-12 concentration. Objective To evaluate the association between depressive and anxiety symptoms in the third trimester of pregnancy and changes in postpartum serum B-12, homocysteine, and B-12 milk concentration. Methods A total of 101 women (18–40 years) were studied in a prospective cohort with data at the third trimester of pregnancy (baseline) and three postpartum time-points (TPs): 2–8 days (TP1), 28–50 days (TP2), and 88-119 days (TP3) postpartum. B-12 concentrations in milk were measured by competitive chemiluminescent enzyme immunoassay at TP1, TP2, and TP3. Serum B-12 and homocysteine concentrations were evaluated at baseline, TP1, TP2, and TP3 by chemiluminescent immunoassays. Depressive and anxiety symptoms were measured with the Edinburgh Postnatal Depression Scale and the State-Trait Anxiety Inventory at baseline. Spearman's correlation test and multiple linear mixed-effect models were performed. Results The prevalence of depressive and anxiety state symptoms was 35.6 and 39.6% at baseline. High prevalence of low milk B-12 concentration (<310 pmol/L) were observed at TP1 (53.2%), TP2 (71.4%), and TP3 (71.1%). Women with anxiety symptoms at baseline presented higher median concentrations of serum homocysteine at TP1 and lower concentrations of serum and milk B-12 at TP2 compared with women without anxiety symptoms [8 (7; 9) vs. 6 (5; 8) and 266 (188; 369) vs. 332 (272; 413)]. Milk B-12 concentrations were positively and significantly correlated with maternal serum B-12 concentrations at different TP. Women with anxiety symptoms at baseline exhibited a decrease in daily postpartum homocysteine concentrations compared to women without anxiety symptoms (β = −0.002, SE = 0.001, p = 0.024). Conclusion Anxiety symptoms at the end of pregnancy were associated with longitudinal changes in maternal serum homocysteine concentrations during the first 3 months postpartum.
Use of Whole-Genome Sequencing to Unravel the Genetic Diversity of a Prevalent Mycobacterium bovis Spoligotype in a Multi-Host Scenario in Spain

Despite the efforts invested in the eradication of bovine tuberculosis in Spain, herd prevalence has remained constant in the country during the last 15 years (~1.5–1.9%) due to a combination of epidemiological factors impairing disease control, including between-species transmission. Here, our aim was to investigate the molecular diversity of Mycobacterium bovis isolates belonging to the highly prevalent SB0339 spoligotype in the cattle-wildlife interface in different regions of Spain using whole-genome sequencing (WGS). Genomic data of 136 M. bovis isolates recovered from different animal species (cattle, wild boar, fallow deer, and red deer) and locations between 2005 and 2018 were analyzed to investigate between- and within-species transmission, as well as within-herds. All sequenced isolates differed by 49–88 single nucleotide polymorphisms from their most recent common ancestor. Genetic heterogeneity was geographic rather than host species-specific, as isolates recovered from both cattle and wildlife from a given region were more closely related compared to isolates from the same species but geographically distant. In fact, a strong association between the geographic and the genetic distances separating pairs of M. bovis isolates was found, with a significantly stronger effect when cattle isolates were compared with wildlife or cattle-wildlife isolates in Spain. The same results were obtained in Madrid, the region with the largest number of sequenced isolates, but no differences depending on the host were observed. Within-herd genetic diversity was limited despite the considerable time elapsed between isolations. The detection of closely related strains in different hosts demonstrates the complex between-host transmission dynamics present in endemic areas in Spain. In conclusion, WGS results a valuable tool to track bTB infection at a high resolution and may contribute to achieve its eradication in Spain.
Satisfaction With Community Health Education Among Residents in China: Results From a Structural Equation Model

Background Although community health education has drawn lots of attention from the public, evidence on resident satisfaction is still sparse. This study aims to explore the relationships among five dimensions (perceived quality, perceived value, public expectation, public trust, and public satisfaction) of satisfaction with community health education among Chinese residents. Methods We constructed a theoretical public satisfaction model for community health education based on the American Customer Satisfaction Index (ACSI) model. There are five dimensions in the theoretical model, including public expectation, perceived quality, perceived value, public satisfaction, and public trust. We recruited 474 respondents from a quota sampling based on gender and age, and collected information on five dimensions of satisfaction with community health education. The relationships of the five dimensions were examined using structural equation model. Results The mean scores of public expectation, perceived quality, perceived value, public satisfaction, and public trust for the participants were 11.44 (total 15), 123.89 (total 170), 14.18 (total 20), 10.19 (total 15), and 15.61 (total 20), respectively. We obtained a structural equation model with a good fitting degree. There was a direct effect of perceived quality on perceived value (γ = 0.85, P < 0.01), public trust (γ = 0.81, P < 0.01) and public satisfaction (γ = 0.58, P < 0.01), and a direct effect of public expectation on public satisfaction (γ = 0.36, P < 0.01) and perceived value (γ = 0.25, P < 0.01). Conclusions We provide a good tool to measure public satisfaction with community health education, which can be potentially used to measure public satisfaction and improve the effectiveness of health education.
Monte Carlo simulations of hard QCD radiation

Monte Carlo event generators, such as Herwig++, provide a full simulation of events at collider experiments. They give a fully exclusive description of hadronic final states and are therefore crucial tools for the planning of future experiments and analysing of data from existing experiments. The key component that allows this description of high-multiplicity final states is the parton shower. There has been much recent progress improving the parton shower description of hard radiation using exact matrix elements. This thesis describes research into implementing and improving such methods within the Herwig++ event generator. In Chapter 1, the parton-shower formalism is reviewed and the structure of event generators described. Chapter 2 details the specifics of the \textsf{Herwig++} parton shower. In Chapters 3 and 4, the POWHEG next-to-leading-order matching procedure is described, and work implementing the scheme within Herwig++ is presented. The method is implemented for the processes e+e- to hadrons and Drell-Yan vector boson production and the results are compared to experimental data from LEP and the Tevatron. This work includes the first full implementation of the truncated shower. A description of the development and implementation of a modified matrix-element merging scheme is presented in Chapter 5. This scheme is based on CKKW merging but uses an extension of the POWHEG idea to improve the method using truncated showers. The method is implemented first for final-state radiation in e+e- to hadrons and then, in Chapter 6, extended to include initial-state radiation in Drell-Yan vector boson production.
Does Robotic Liver Surgery Enhance R0 Results in Liver Malignancies during Minimally Invasive Liver Surgery?—A Systematic Review and Meta-Analysis

Simple Summary The resection margin status is one of the most relevant oncological factors in liver cancer surgery. Whether robotic liver surgery enhances R0 results in liver malignancies during minimally invasive liver surgery is not yet completely clear. We conducted a systematic review with meta-analysis to compare robotic and laparoscopic approaches in liver surgery with particular attention to the resection margin status in liver malignancies. Abstract Background: Robotic procedures are an integral part of modern liver surgery. However, the advantages of a robotic approach in comparison to the conventional laparoscopic approach are the subject of controversial debate. The aim of this systematic review and meta-analysis is to compare robotic and laparoscopic liver resection with particular attention to the resection margin status in malignant cases. Methods: A systematic literature search was performed using PubMed and Cochrane Library in accordance with the PRISMA guidelines. Only studies comparing robotic and laparoscopic liver resections were considered for this meta-analysis. Furthermore, the rate of the positive resection margin or R0 rate in malignant cases had to be clearly identifiable. We used fixed or random effects models according to heterogeneity. Results: Fourteen studies with a total number of 1530 cases were included in qualitative and quantitative synthesis. Malignancies were identified in 71.1% (n = 1088) of these cases. These included hepatocellular carcinoma, cholangiocarcinoma, colorectal liver metastases and other malignancies of the liver. Positive resection margins were noted in 24 cases (5.3%) in the robotic group and in 54 cases (8.6%) in the laparoscopic group (OR = 0.71; 95% CI (0.42–1.18); p = 0.18). Tumor size was significantly larger in the robotic group (MD = 6.92; 95% CI (2.93–10.91); p = 0.0007). The operation time was significantly longer in the robotic procedure (MD = 28.12; 95% CI (3.66–52.57); p = 0.02). There were no significant differences between the robotic and laparoscopic approaches regarding the intra-operative blood loss, length of hospital stay, overall and severe complications and conversion rate. Conclusion: Our meta-analysis showed no significant difference between the robotic and laparoscopic procedures regarding the resection margin status. Tumor size was significantly larger in the robotic group. However, randomized controlled trials with long-term follow-up are needed to demonstrate the benefits of robotics in liver surgery.
Promoting Learning Through ESP ToT for Legal English Instructors

In the current ongoing globalization trend and competitive job-market specialized skills and specific preparation are required. In this climate Kosovo is continuously facing challenges to meet learners’ needs and reform teaching from traditional to learning-centered teaching that will closely consider learners’ needs and prepare them for target situations. The demand and interest for English for Specific Purposes (ESP) is growing everyday as challenges rise while in search of prosperous employment or further studies and research, both crucial to professional and academic development. Moreover Kosovo is preparing for accession into European Union and Stabilization and Association Agreement (SAA) negotiations have already started. This emphasizes the importance of legal English in this region, specialized language skills and expertise especially in the legal domain. This study aims to explore the importance of teacher attitudes and roles in an ESP setting. A Train of Trainers (ToT) Program, aimed at Legal English instructors, carried out by ESP practitioners while emphasizing appropriate teaching methodology, focused on preparing instructors to teach further in the ESP field with focus in legal English. The study investigates the ground for implementing ESP as pedagogy at Kosovo Judicial Institute (KJI) in Prishtina, and broader in other institutions throughout. The results of this study will hopefully serve as a recommendation to ESP teachers and assist them when dealing with the challenges of teaching ESP courses in practice.
Influence of Recipe Factors on the Structure and Properties of Non-Autoclaved Aerated Concrete of Increased Strength

At present, the load-bearing enclosing structures of buildings and structures are designed and built considering the increasing requirements for energy efficiency and energy saving of such structures. This is due to the need for a thrifty attitude to the energy consumed and the need to strive for the greening of construction and increase the energy efficiency of buildings and structures. In this regard, one of the most effective and proven building materials is cellular concrete. The purpose of this study was to study the influence of some prescription factors on the structure formation and properties of non-autoclaved aerated concrete with improved characteristics. Standard test methods were used, as well as SEM analysis of the structure of aerated concrete. Non-autoclaved aerated concrete with the replacement of part of the cement with microsilica in an amount from 4% to 16% MS showed higher strength characteristics compared to aerated concrete, where part of the cement was replaced by the addition of granulated blast-furnace slag and a complex additive. The maximum value of compressive strength was recorded for aerated concrete with 16% MS addition. The largest increase in the coefficients of constructive quality was observed in compositions of aerated concrete with the addition of silica fume from 11% to 46% compared with the control composition. The addition of microsilica makes it possible to achieve an improvement in the thermal conductivity characteristics of non-autoclaved aerated concrete (up to 10%). Replacing part of the cement with slag and complex additives does not have a significant effect on thermal conductivity. The obtained dependencies were confirmed by the analysis of the structure formation of the studied aerated concrete at the micro level. An improvement in the microstructure of aerated concrete with the addition of microsilica in comparison with samples of the control composition has been proven.