Miracle-dz/UniFAR-FTUs huggingface dataset:
Virtual reality and augmented reality as strategies for teaching social skills to individuals with intellectual disability: A systematic review

Virtual reality (VR) and augmented reality (AR) programs have proliferated significantly in recent years and they are finding their way into different educational and therapeutic purposes. This systematic review aims at analyzing the virtual reality and augmented reality programs designed to promote the development of social skills in individuals with intellectual disability. Searches were carried out in the Scopus, Science Direct, Springer and Web of Science databases in the period from 2005 to 2020. A total of six articles met the inclusion criteria. A descriptive data analysis was performed. The results show that the clinical profile of the individuals who participated in the interventions is diverse. It can be concluded that there is some scientific evidence that points to the usefulness of VR and AR in the development of intervention programs to improve the social skills of individuals diagnosed with developmental deficits. However, it is necessary to acknowledge methodological limitations such as the lack of control groups, follow-up measures and of generalization of the results.
The Interaction of Cue Type and Its Associated Behavioral Response Dissociates the Neural Activity between the Perirhinal and Postrhinal Cortices

Abstract The perirhinal cortex (PER) and postrhinal cortex (POR) in the medial temporal lobe are commonly described as two distinct systems that process nonspatial and spatial information, respectively. Recent findings suggest that the two regions exhibit functional overlap when processing stimulus information, especially when associative responses are required in goal-directed behavior. However, we lack the neural correlates of this. In the current study, we recorded spiking activities for single units of the PER and POR as rats were required to choose a response associated with the identity of a visual object or scene stimulus. We found that similar proportions of cells fired selectively for either scene or object between the two regions. In the PER and POR, response-selective neurons showed higher contrast for different responses than stimulus-selective cells did for stimuli. More cells fired selectively for specific choice response in the POR than in the PER. The differential firing patterns of the PER and POR were best explained when the stimulus and response components were considered together: Stimulus-selective cells were modulated more by the response in the POR than in the PER, whereas response-selective cells in the PER were modulated more by object information than by scenes. Our results suggest that in a goal-directed memory task, the information processing in the PER and POR may be dynamically modulated not only by input stimulus information but also by the associated choice behavior and stimulus–response interaction.
Self-Compassion and Happiness: Exploring the Influence of the Subcomponents of Self-Compassion on Happiness and Vice Versa

Self-compassion is a healthy conceptualization of the self and has been associated with a myriad of health benefits. There is limited research regarding the influence of the subcomponents of self-compassion on happiness and vice versa. This study investigated (1) the influence and relative strength of the relationships of the 6 subcomponents of self-compassion onto happiness, (2) the influence and relative strength of the relationships of happiness onto the 6 subcomponents of self-compassion and (3) the bi-directional relationship between total self-compassion variables and happiness across two timepoints. This study followed a pre-post design whereby 33 university students and employees undergoing a physical activity counselling (PAC) program filled out validated online questionnaires before and immediately after individualized sessions. Results revealed that there was a positive bi-directional relationship between self-compassion and happiness over time, with the stronger influence being from happiness to self-compassion. This is likely because happier individuals are kinder to themselves and strongly connected with others. Moreover, results showed that mindfulness was the strongest subcomponent of self-compassion to positively influence happiness, and happiness was the strongest negative predictor of isolation. This has practical implications in that PAC counsellors and other practitioners should try to emphasize mindfulness in their interventions to maximize feelings of happiness, and try to cultivate happiness to reduce feelings of isolation and increase total self-compassion.
Prevalence of amyotrophic lateral sclerosis in the United States using established and novel methodologies, 2017

Abstract Objective:To estimate the prevalence of amyotrophic lateral sclerosis (ALS) in the United States for 2017 using data from the National ALS Registry (Registry) as well as capture–recapture methodology to account for under-ascertainment. Established in 2010, the Registry collects and examines data on ALS patients in the US to better describe the epidemiology of ALS (i.e. risk factor exposures, demographics). Methods: The Registry compiled data from national administrative databases (from the Centers for Medicare and Medicaid Services, the Veterans Health Administration, and the Veterans Benefits Administration) and a voluntary enrollment data through a web portal (www.cdc.gov/als). To estimate the number of missing cases, capture–recapture methodology was utilized. Results: The Registry conservatively identified 17,800 adult persons (lower-bound estimate) who met the Registry definition of ALS for an age-adjusted prevalence of 5.5 per 100,000 US population. Using capture–recapture methodology, we obtained a “mean case count” of 24,821 ALS cases (prevalence of 7.7 per 100,000 U.S. population) and estimated the upper-bound estimate to be 31,843 cases (prevalence of 9.9 per 100,000 U.S. population). The pattern of patient characteristics (e.g. age, sex, and race/ethnicity) remained unchanged from previous Registry reports. Overall, ALS was most common among whites, males, and persons aged 60–69 years. The age groups with the lowest number of cases were persons aged 18–39 years. Males had a higher prevalence than females overall and across all data sources. Conclusions: Existing Registry methodology, along with capture-recapture methodology, are being used to better describe the epidemiology and demographics of ALS in the US.
A Systematic Review and Meta-Analysis of Extracorporeal Membrane Oxygenation in Patients with Burns

Background: Severely burned patients are at high risk for cardiopulmonary failure. Promising studies have stimulated interest in using extracorporeal membrane oxygenation as a potential therapy for burn patients with refractory cardiac and/or respiratory failure. However, the findings from previous studies vary. Methods: In this study, the authors conducted a systematic review and meta-analysis using standardized mortality ratios to elucidate the benefits associated with the use of extracorporeal membrane oxygenation in patients with burn and/or inhalation injuries. A literature search was performed, and clinical outcomes in the selected studies were compared. Results: The meta-analysis found that the observed mortality was significantly higher than the predicted mortality in patients receiving extracorporeal membrane oxygenation (standardized mortality ratio, 2.07; 95 percent CI, 1.04 to 4.14). However, the subgroup of burn patients with inhalation injuries had lower mortality rates compared to their predicted mortality rates (standardized mortality ratio, 0.95; 95 percent CI, 0.52 to 1.73). Other subgroup analyses reported no benefits from extracorporeal membrane oxygenation; however, these results were not statistically significant. Interestingly, the pooled standardized mortality ratio values decreased as the selected patients’ revised Baux scores increased (R = −0.92), indicating that the potential benefits from the treatment increased as the severity of patients with burns increased. Conclusions: The authors’ meta-analysis revealed that burn patients receiving extracorporeal membrane oxygenation treatment were at a higher risk of death. However, select patients, including those with inhalation injuries and those with revised Baux scores over 90, would benefit from the treatment. The authors suggest that burn patients with inhalation injuries or with revised Baux scores exceeding 90 should be considered for the treatment and early transfer to an extracorporeal membrane oxygenation center.
Finite-Time Adaptive Neural Control for a Class of Nonlinear Systems With Asymmetric Time-Varying Full-State Constraints

In this article, an adaptive finite-time tracking control scheme is developed for a category of uncertain nonlinear systems with asymmetric time-varying full-state constraints and actuator failures. First, in the control design process, the original constrained nonlinear system is transformed into an equivalent “unconstrained” one by using the uniform barrier function (UBF). Then, by introducing a new coordinate transformation and incorporating it into each recursive step of adaptive finite-time control design based on the backstepping technique, more general state constraints can be handled. In addition, since the nonlinear function in the system is unknown, neural network is employed to approximate it. Considering singularity, the virtual control signal is designed as a piecewise function to guarantee the performance of the system within a finite time. The developed finite-time control method ensures that all signals in the closed-loop system are bounded, and the output tracking error converges to a small neighborhood of the origin. At last, the simulation example illustrates the feasibility and superiority of the presented control method.
Transcultural Adaptation and Psychometric Support for a Brazilian Portuguese Version of the Flow State Scale (FSS-2)

The flow experience in sports is a construct of great interest to recreational and competitive athletes, coaches, and psychologists in pursuit of optimal performance. As there are no validated instruments for evaluating flow in the Brazilian Portuguese language, we evaluated the psychometric properties of a Brazilian version of the Flow State Scale (FSS-2) through three steps. Initially, four translators and five sports psychology specialists adapted the FSS-2 content for the Brazilian Portuguese language. Second, 371 athletes of both sexes who were engaged in group and individual sport modalities and who participated in national university sports competitions from 24 states responded to the adapted version of the FSS-2. Third, an independent sample of 34 athletes from Paraná responded to both the adapted FSS-2 and the dispositional flow scale (DFS-2) to permit analysis of the external validity and temporal stability of the adapted FSS-2. We found that the Brazilian version of the FSS-2 contains clear and pertinent items with a good content validity coefficient (CVC = 0.94) and satisfactory internal consistency (α > 0.88/CC > 0.80). Confirmatory factor analysis revealed that the adapted 36-item model presented adequate fit [X2 (558) = 1258.85; X2/df = 2.256; comparative fit index (CFI) = 0.92; non-normed fit index (NNFI) = 0.90; Tucker–Lewis Index (TLI) = 0.91; root mean square error of approximation (RMSEA) = 0.06 (0.05–0.06); (RMSEA <0.05) =. 001] with all first order factors (challenge-skills balance, action-attention fusion, clear goals, feedback, intense concentration, control, loss of self-awareness, time transformation, and autotelic experience). External validity (r > 0.344) and temporal stability (0.53 < intraclass correlation coefficient (ICC) < 0.86) were satisfactory. We conclude that the Brazilian version of FSS-2 is adequate to evaluate flow states experienced by Brazilian athletes following a sports competition.
Morphological characteristics of symptomatic and asymptomatic carotid webs.

OBJECTIVE Carotid webs (CWs) are an increasingly recognized source of recurrent stroke among young patients without conventional vascular risk factors. There have been no previous studies demonstrating that specific web morphological characteristics correlate with a higher stroke risk. The authors aim to report distinct morphological features of symptomatic and asymptomatic CWs. METHODS The authors performed a cross-sectional study of patients with CWs detected on CT angiography (CTA) of the neck. Patients were categorized based on whether or not they presented with stroke ipsilaterally and if it was likely to be attributable to their web. The following CW morphological variables were recorded and compared based on CTA: length, thickness, angle, and the proportion of carotid bulb lumen occupied by the web (web-to-bulb ratio [WBR]). RESULTS A total of 86 CWs were identified, 14 of which presented with stroke (16.3%). Patients presenting with stroke had webs that were significantly longer (4.18 mm vs 2.20 mm, p = 0.001) and were situated at more acute angles relative to the carotid wall (73.2° vs 94.9°, p = 0.004). Additionally, patients presenting with stroke had higher WBRs compared to the asymptomatic cohort (0.50 vs 0.36, p = 0.008). The optimal threshold associated with stroke was web length ≥ 3.1 mm (OR 15.2, 95% CI 3.73-61.8; p < 0.001), web angle ≤ 90.1° (OR 5.00, 95% CI 1.42-17.6; p = 0.012), and WBR ≥ 0.50 (OR 30.0, 95% CI 5.94-151; p < 0.001). CONCLUSIONS Patients with CWs that occupy more than half of the diameter of the carotid bulb lumen and are situated at acute angles relative to the carotid wall are more likely to present with acute ischemic stroke. Additional studies are needed to determine the long-term outcomes of these lesions.
Can restoration of fire-dependent ecosystems reduce ticks and tick-borne disease prevalence in the eastern United States?

Over the past century, fire suppression has facilitated broad ecological changes in composition, structure, and function of fire-dependent landscapes of throughout the eastern US which are in decline. These changes have likely contributed mechanistically to the enhancement of habitat conditions that favor pathogen carrying tick species, key wildlife hosts of ticks, and interactions that have fostered pathogen transmission among them and to humans. While the long-running paradigm for limiting human exposure to tick-borne diseases focuses responsibility on individual prevention, the continued expansion of medically important tick populations, increased incidence of tick-borne disease in humans, and emergence of novel tick-borne diseases highlights the need for additional approaches to stem this public health challenge. Another approach that has the potential to be a cost effective and widely applied, but remains largely overlooked, is the use of prescribed fire to ecologically restore degraded landscapes that favor ticks and pathogen transmission. We examine the ecological role of fire and its effects on ticks within the eastern US, especially examining the life cycles of forest-dwelling ticks, shifts in regional-scale fire use over the past century, and the concept that frequent fire may have helped moderate tick populations and pathogen transmission prior to the "fire suppression era" that has characterized the past century. We explore mechanisms of how fire and ecological restoration can reduce ticks, the potential for incorporating the mechanisms into the broader strategy for managing ticks, and the challenges, limitations, and research needs of prescribed burning for tick reduction.
Novel Biomarkers of Health and Degeneration in Human Intervertebral Discs: In-depth Proteomic Analysis of Collagen Framework of Fetal, Healthy, Scoliotic, Degenerate, and Herniated Discs

Study Design Profiling proteins expressed in the nucleus pulposus (NP) of intervertebral discs (IVDs) in five different biological states. Purpose To evaluate the molecular complexity of the collagen (COL) framework and its role in the health and disease of human IVDs. Overview of Literature Changes in COL composition have been linked to degenerative disk disease (DDD). Despite the fact that humans have 28 different types of COLs, most of the literature focuses solely on COL-1 and COL-2. This study used high-end proteomic technology to examine the entire COL composition of the human IVD across fetal (developmental-FD), normal (healthy-ND), scoliotic (early degeneration-SD), herniated (degenerate-DH), and degenerated (DD) disk phenotypes. Methods Forty NP tissues were snap-frozen in liquid nitrogen (−196°C) immediately before being subjected to proteomic and bioinformatic analyses from five different disk phenotypes (eight each). Results Tandem mass spectrometric analysis revealed a total of 1,050 proteins in FDs, 1,809 in ND, 1,487 in SD, 1,859 in DH, and 1,538 in the DD group. Of 28 major collagens reported in the human body, this study identified 24 different collagens with 34 subtypes in NP. Fibril-forming collagens (COL-1, 2, and 11A1) and fibril-associated collagens with interrupted triple helices (COL-9A1, 12A1, and 14A1) were abundantly expressed in FDs, representing their role in the development of NP. Multiplexin (COL-15), a hybrid proteoglycan–collagen molecule, was discovered only in FDs. Degeneration was associated with COL2A1 downregulation and COL-10A1 upregulation. Conclusions COL10 was discovered to be a new biomarker for disk degeneration. Besides COL-1 and 2, other important COLs (6, 9, 11, 12, 14, 15) with anabolic potential and abundant expression in the fetal phenotype could be investigated for tissue engineering and novel DDD therapy.
Adjuncts to pulsed dye laser for treatment of port wine stains: a literature review

ABSTRACT Noninvasive pulsed dye laser is the current gold standard for the treatment of port wine stains. However, most port wine stains are not completely cleared after pulsed dye laser therapy, owing to insufficient photocoagulation and laser-induced vascular regeneration and reperfusion. Several studies have explored approaches designed to improve treatment efficacy. This integrative literature review summarizes the results of clinical and animal studies published between 2004 and 2021. Pulsed dye laser has been administered in combination with photoelectric devices (the neodymium: yttrium-aluminum-garnet lasers, dual-wavelength 1064-/595-nm laser irradiation, fiberoptic Nd-YAG laser, photodynamic therapy, and radio frequency), and drugs (rapamycin, imiquimod, timolol, axitinib, endothelin receptor antagonist, artificial red blood cells and oxymetazoline). The initial results suggest that combination therapy is a direction worth exploring in the future. Further large prospective, blinded and controlled multicenter clinical trials with longer follow‐up period are required to obtain more robust evidence.
Prevalence of clinical signs and factors impacting expression of myosin heavy chain myopathy in Quarter Horse‐related breeds with the MYH1 E321G mutation

Abstract Background The prevalence of clinical signs and factors triggering muscle atrophy and rhabdomyolysis associated with an MYH1 E321G mutation in Quarter Horses and related breeds (QH) remain poorly understood. Hypothesis/Objectives Determine the prevalence and potential triggers of atrophy and stiffness in horses homozygous reference (N/N), heterozygous (My/N), and homozygous (My/My) for the MYH1 E321G mutation. Animals Two‐hundred seventy‐five N/N, 100 My/N, and 10 My/My QH. Methods A retrospective case‐control study using a closed‐ended questionnaire completed by clients of the Veterinary Genetics Laboratory at the University of California, Davis. History of clinical signs, disease, vaccination and performance were analyzed by genotype using contingency testing. Results Atrophy occurred in proportionately more horses with MYH1 E321G (My) than N/N QH and more frequently in My/My than My/N QH (P < .001; My/My 8/10 [80%], My/N 17/100 [17%], N/N 29/275 [11%]). More My/My horses had rapid atrophy (P < .001), with recurrence in 50%. Fewer My/My horses recovered versus My/N QH (P < .001). Stiffness was common across genotypes (P = .100; My/My 4/10 [40%], My/N 18/100 [18%], N/N 48/275 [17%]). Three months before the observed atrophy and stiffness, 47% of MYH1 E321G QH were vaccinated or had respiratory or gastrointestinal disease. Horses achieving 100% expected performance did not differ across genotypes (50% My/My, 71% My/N, 55% N/N), but, only 4/10 My/My QH were competing. My/N horses achieved national or world championships or both. Conclusion and Clinical Importance Approximately 20% of My/N QH develop rapid atrophy. Atrophy is more common (80%) in homozygous My/My QH and less likely to resolve. Inciting causes such as vaccination and infection are inapparent in over half of cases.
Establishment and validation of a T12-L2 3D finite element model for thoracolumbar segments.

OBJECTIVE To establish and verify the validity of a three-dimensional finite element model of the thoracolumbal segments T12-L2; the stress distribution of the model was analyzed, providing a theoretical basis for finite element analysis of thoracolumbal segment fracture as well as a surgical model. METHODS A healthy female volunteer with no history of lumbar spine injury was selected to obtain CT scan data of the T12-L2 vertebral bodies. Mimics 3D reconstruction software was used to generate the T12-L2 3D model, and surface mesh and body mesh were generated by smoothing treatment and mesh division. The normal finite element model of the T12-L2 vertebral bodies and the finite element model of osteoporosis were established with Ansys finite element software. Under a loading force of 500 N vertically downward and a load of 7.5 N•m bending moment, seven operating conditions were simulated to analyze the displacement and stress distribution of each vertebral body and intervertebral disc, and to verify the effectiveness of the model. RESULTS There were 31,901 nodes and 64,244 elements in the thoracolumbar T12-L2 three-dimensional finite element model. These results were similar to the conclusions found in a review of the domestic and global literature, and the finite element model was validated. CONCLUSIONS The results of this experiment can provide a practical reference for clinical work and help to establish a three-dimensional finite element model of the thoracolumbar junction.
Limited time‐specific and longitudinal effects of depressive and manic symptoms on cognition in bipolar spectrum disorders

Previous research suggests that cognitive performance worsens during manic and depressed states in bipolar disorder (BD). However, studies have often relied upon between‐subject, cross‐sectional analyses and smaller sample sizes. The current study examined the relationship between mood symptoms and cognition in a within‐subject, longitudinal study with a large sample.