Miracle-dz/UniFAR-FTUs huggingface dataset:
Anxiety and depression symptoms in adults and elderly in post-percutaneous coronary intervention

Cardiovascular diseases are among the leading causes of disability and death. One of the forms of treatment for them is the percutaneous coronary intervention (PCI). After a diagnosis or cardiac procedure, patients have psychological symptoms that often go unnoticed and interfere with their health condition. The aim of this article was to evaluate the intensity of anxiety and depression symptoms in adult and elderly patients hospitalized after PCI. The design of the study was cross-sectional, analytical, correlational and comparative. Participants were 266 patients who had undergone PCI. Their average age was 64.5 years (SD =8.9 years) and most of them were men (68%) with a diagnosis of acute myocardial infarction (AMI) (64.3%). The research instruments used were the Beck Anxiety Inventory (BAI) and the Beck Depression Inventory - Second Edition (BDI-II). Data collection was performed during the patients' hospitalization and statistical analysis was carried out by means of the Chi-SquareTest, the Kolmogorov -Smirnov Test and ANOVA. The level of significance used wasp < . 05. Results showed that the majority of patients presented severe symptoms of anxiety (29.7%) and minimum intensity depressive symptoms (51.9%). The study highlights the importance of assessing and treating psychological symptoms after PCI as these interfere with the patient's adherence to treatment and with their quality of life.
POTENTIAL BENEFITS FOR USING ePTFE AS A MATERIAL FOR PROSTHETIC HEART VALVES

Background The current study highlights potential benefits of using ePTFE, a polymeric material, as the main component suitable for fabrication of prosthetic heart valves. Novel polymeric materials seem to be promising for replacing biological elements commonly used in medical products for cardiovascular surgery. High biocompatibility and mechanical properties prolong their lifespan during direct blood contact. Nevertheless, it is necessary to conduct a series of specific tests to determine their properties and benefits of their application. Despite well-known biological properties of ePTFE, there are few studies assessing it as a material for heart valve leaflets. Aim To evaluate the mechanical properties of the commercially available sample of ePTFE and to conduct a numerical experiment assessing its potential for the application. Methods The polymer properties (Gore & Associates Inc., USA) were evaluated under uniaxial tension in two mutually perpendicular directions to determine the degree of anisotropy of the material. A xenopericardial patch (ZAO “NeoCor”, Russia), routinely used for the fabrication of bioprosthetic leaflets, was taken as the control sample. The spatial model of the investigated material was carried out in CAD SolidWorks 2016 (Dassault Systemes, USA). Numerical modeling of the samples was performed with the finite element method using the orthotropic material model in the Abaqus/CAE (Dassault Systemes, USA). Results There are significant difference found in the mechanical properties of the studied materials: the tension at stretching of ePTFE in the longitudinal and transverse directions differed from xenopericardium by 1.9 and 7.5 times, respectively (p<0.05). The elongation before rupture of ePTFE in direction I and direction II was greater than that of xenopericardium (2.39 vs. 1.9 times, respectively). Numerical modeling demonstrated insignificant qualitative differences in the valve opening while applying pressure equal to normal physiological pressure>< 0.05). The elongation before rupture of ePTFE in direction I and direction II was greater than that of xenopericardium (2.39 vs. 1.9 times, respectively). Numerical modeling demonstrated insignificant qualitative differences in the valve opening while applying pressure equal to normal physiological pressure and low pressure. In addition, the zones of high stress in commissural racks, which are critical zones for fatigue resistance, have been identified, albeit require additional in vitro research. Conclusion Mechanical properties of ePTFE suggests it to be a promising polymeric material suitable for fabrication of flexible leaflets of the heart valve prosthesis. It has similar leaflet functioning, compared with the xenopericardium sample, routinely used in manufacturing. ePTFE is more resistant to rupture, which confirms its greater fatigue strength. However, it requires further study by advanced methods.
Longitudinal study of Salmonella infection in four Italian farrow-to finish swine herds

A longitudinal study of Salmonella enterica infection was carried out in 4 Italian farrow-to-finish swine herds. In each herd 5 litters were randomly selected and in each litter 6 piglets ear tagged. Thus, on each farm 30 pigs were included in the study. Individual blood samples were collected for serologic examination at weaning from all piglets and in the same day from all sows 1n the farrowing unit. Piglets were bled again at approximately 60, 90, 150, 210 and 270 days of life with the last blood sample collected at slaughtering . In one herd, in which the duration of productive cycle was abou t 12 months, the last blood samples was collected at 350 days of life. 5 pen pooled faeca l samples were collected from each herd for bacteriological examination with the same time schedule of blood samples. At slaughtering mesenteric lymph nodes were collected from each ear tagged pig . Sera-prevalence (cutoff S/P ratio 0,25) in sows varied from 93,8% to 100%. In all herds sera-prevalence in piglets showed a similar profile with complete decline of maternal antibodies at day 60 and clear sera-conversion between day 90 and day 150. The peak of sera-prevalence was observed between day 210 and day 270. Sera-prevalence at slaughtering varied from 66% to 100%. Salmonella was isolated from faecal samples in 3 out of 4 herds. No Salmonella was isolated from mesenteric lymph nodes at slaughter in 2 herds. Culture prevalence from mesenteric lymph nodes in the other herds was respectively 3,3% and 30%. This longitudinal study provides original information about epidemiological dynamics of Salmonella enterica infection in Italian swine herds in consideration of the typical longer fattening cycles.
PRACTICAL CONSIDERATIONS FOR STANDARDIZED RECORDING OF MUSCLE MECHANICAL PROPERTIES USING A MYOMETRIC DEVICE: RECORDING SITE, MUSCLE LENGTH, STATE OF CONTRACTION AND PRIOR ACTIVITY

Purpose: This study aimed to systematically examine the influence of various muscle and experimental conditions on Myoton recordings. Methods: A cross-sectional, observational design was used to examine muscle conditions and experimental factors (different recording sites, muscle length, level of contraction and prior physical activity) that may influence reproducibility of Myoton recordings for biceps brachii (BB) and rectus femoris (RF). Fifty-three healthy adults (26 young, 27 older) aged 18–90 years were studied. Muscle stiffness, tone and elasticity were measured using the MyotonPRO device. Results: Statistically significant differences in Myoton parameters were found for aspects of all four muscle and experimental conditions compared with the control condition ([Formula: see text]). However, clinically relevant differences in tone, stiffness and elasticity were only found for contracted compared to resting muscle, with changes being greater than the minimal detectable change. Elasticity was not affected by prior activity. Conclusions: The conditions studied significantly altered Myoton parameters of BB and RF in healthy adults, but only changes in parameters during muscle contraction were clinically relevant. These findings provide evidence to support the need to consider muscle condition and experimental factors for improving the robustness of test protocols for assessing muscle mechanical properties using the MyotonPRO device.
Perioperative Dexmedetomidine Improves Outcomes of Cardiac Surgery

Background—Cardiac surgery is associated with a high risk of cardiovascular and other complications that translate into increased mortality and healthcare costs. This retrospective study was designed to determine whether the perioperative use of dexmedetomidine could reduce the incidence of complications and mortality after cardiac surgery. Methods and Results—A total of 1134 patients who underwent coronary artery bypass surgery and coronary artery bypass surgery plus valvular or other procedures were included. Of them, 568 received intravenous dexmedetomidine infusion and 566 did not. Data were adjusted with propensity scores, and multivariate logistic regression was used. The primary outcomes measured included mortality and postoperative major adverse cardiocerebral events (stroke, coma, perioperative myocardial infarction, heart block, or cardiac arrest). Secondary outcomes included renal failure, sepsis, delirium, postoperative ventilation hours, length of hospital stay, and 30-day readmission. Dexmed.
A cross sectional study for utilisation of antenatal care services and its association to birth weight of babies in a tertiary care centre in Western India

Background: Low birth weight is a major public health problem in India. Amongst several factors affecting birth weight, the two crucial factors are demographic characteristics of mothers and utilisation of antenatal care services. Identification of these bottlenecks will help in forming suitable strategies to mitigate the problem of low birth weight in developing countries.Methods: This was a cross-sectional study conducted in a medical college hospital of Gujarat. All the mothers admitted in maternity ward for delivery during July 2017 and had given informed consent, were involved in the study. Interview consisted of demographic characteristic of mothers, utilisation of antenatal services and records of pregnancy outcome. Data were entered in excel 2010 and analysed using Epi info 7.2. Strength of association between LBW and risk factors was obtained using odds ratio test.Results: Majority of the mothers had registered for antenatal care within the first trimester (78%) and had taken minimum of four ANC visits (93%). One fifth (18%) of the mothers had babies weighing less than 2.5 kgs. Lower education status of mothers, multigravida, and mothers with less than four ANC visits, preterm births and female foetus were significantly at higher risk of low birth weight as compared to their counterparts.Conclusions: The factors determining LBW were lower education status of mothers, multigravidity, inadequate ANC visits, preterm births and female sex of foetus. We recommend that increasing the education status of masses, particularly of females and ensuring adequate ANC utilisation will reduce the problem of LBW.
Plasma Matrix Metalloproteinase-9 as a Marker of Blood Stasis in Varicose Veins

Background— Possible intermediate circulating markers linking blood stasis to vein remodeling were explored in patients with varicose veins in the lower limbs. Methods and Results— Blood was sampled at rest (supine position) and after a stasis of 30 minutes both in the varicose vein (limbs hanging down) and in the brachial vein (arm hanging down) as a paired control. Several endothelial and leukocyte markers were measured in plasma with the use of ELISA kits. Angiotensin-converting enzyme activity was determined by use of a specific substrate. Matrix metalloproteinases (MMPs) 9 and 2 were evaluated with the use of gelatin zymography. No markers were significantly modified after 30 minutes of blood stasis in the brachial vein. After 30 minutes of blood stasis in the varicose vein, oxygen partial pressure decreased (P<0.01). Although thrombomodulin, von Willebrand factor, vascular endothelial growth factor, and MMP-2 were not modified in these conditions, the proteins released by proteolysis from the endoth.
Effectiveness of NA External Fixator with T-clamp in treating Open proximal and Distal Fractures of Tibia

Objective: To compare the outcomes of the open proximal and distal fractures of tibia treated by Nasser Awais External Fixator with T-clamp. Methodology: This cross sectional study was carried out in the department of orthopaedics Nishtar hospital, Multan in one year duration from July 2016 to July 2017. Study was started after ethical approval from hospital ethical board. Collected data of all patients was entered in SPSS software version 23 and analyzed. Mean and SD was calculated for quantitative data like age, frequency and percentages were calculated for qualitative data gender. Chi square was applied to see association of outcome variables with other variables and confounder. P value ≤ 0.05 was considered as significant. Results: Overall, there were 100% (n=180) patients; 50% (n=90) in each of the two groups. Clinical results were excellent in 88.9% (n=80) patients, good in 7.8% (n=7) patients and fair in 3.3% (n=3) patients in group A. While, in group B, the clinical results were excellent in 83.3% (n=75) patients, good in 10% (n=9) patients and fair in 6.7% (n=6) patients. No association was found between clinical results and the groups (χ 2 = 1.411 DF = 2, P value=0.494). Conclusion: Nasser Awais External Fixator with T-Clamp is a safe and effective technique that enhances the union rate with a low complication rate with less union time in distal tibial fracture compared to proximal fracture. Keywords: NAEF, Tibia, Open proximal, T Clamp, External Fixator.
Investigating the role ofGamma-aminobutyric acid (GABA) in sedation: a combinedelectrophysiological, haemodynamicand spectroscopic study in humans

A better understanding of the mechanisms of anaesthesia and sedation are expected not only to improve the understanding of the neural correlates of consciousness but also to help improve safety from the complications of anaesthesia/ sedation and develop safer drugs and objective brain function monitoring systems. Neuroimaging modalities such as functional MRI, magnetoencephalography and MR spectroscopy provide complimentary information about brain functions and can help interrogate brain activity in a living human brain. Most anaesthetic drugs act by enhancing the inhibitory actions of GABA in the brain. Most neuroimaging research has focused on anaesthetic-induced unconsciousness, with only few investigating the earliest levels of sedation-induced altered consciousness. The work in this thesis used a range of advanced neuroimaging modalities to investigate the role of GABA (through a GABA-ergic drug, propofol), during mild sedation, in humans. This was performed as a series of experiments within two, sequential, scanning sessions, MEG followed by fMRI, in the same participants. Propofol resulted in a dissociation of the visual gamma band response (decreased evoked, increased induced power). This was related to a reduced BOLD fMRI response but there were no changes in MRS detectable GABA concentration. Response to multisensory stimulation also revealed interesting changes with MEG and fMRI. Functional connectivity analyses showed changes in connectivities of the posterior cingulate cortex (key hub of default-mode network) and thalamus with each other and other key brain regions. Resting state networks were identified with MEG too, which revealed interesting increases in connectivity in certain band- limited networks while motor networks showed no change. Perfusion fMRI using arterial spin labelling revealed a global and regional reduction in perfusion, highlighting some of the key regions (frontal cortex, precuenus, PCC and thalamus) involved in sedation.
Retroperitoneal paraganglioma causing proximal ureteric obstruction in a child: diagnostic conundrum and immunohistochemistry characteristics (case report)

Paragangliomas are extremely rare neuroendocrine tumors with an incidence of 0.3 cases per million in children. They arise from several sites in the body including the orbit, ear, nose, larynx, carotid area, mediastinum, duodenum, and the genitourinary tract. Germline mutations have been identified in paragangliomas involving the proto-oncogene RET, tumor suppressor genes VHL, and NF1 The commonest clinical presentation is hypertension but incidentally detected forms have been reported during imaging and on a few occasions the diagnosis was missed. The authors report on a case of a 12-year-old male with a history of fever, left flank pain, vomiting, and headaches, finally diagnosed by pathological examination of a resected retroperitoneal mass invading the proximal left ureter. Immunohistochemistry was positive for neuron-specific enolase, NSE (chief cells), and S-100 protein (sustentacular cells) all consistent with paragangliomas. The challenges faced by the team in the preoperative evaluation and surgical treatment are reported.
Molecular Detection, Virulence Genes, Biofilm Formation, and Antibiotic Resistance of Salmonella enterica Serotype enteritidis Isolated from Poultry and Clinical Samples

Background: Salmonella spp. is one of the most important zoonotic pathogens transmitting among human and animals. Due to the similarity of antibiotic classes used to treat animals and humans, there is a high risk for emerging the multi-drug resistant (MDR) strains. Objectives: The current study aimed at evaluating molecular detection, virulence genes, biofilm formation, and antibiotic resistance of Salmonella enterica serotype enteritidis recovered from poultry and clinical isolates. Methods: A total of 282 isolates were recovered from chicken meat, live poultry feces, eggs, and human feces in Iran. The presence of virulent factors in the isolates was confirmed using biochemical and microbiological tests. The presence of Salmonella genus was determined using antiserum. Triplex polymerase chain reaction (PCR) was performed to detect Salmonella spp. , serogroup D and the discriminate S. enteritidis from other species. Kirby-Bauer disk diffusion method was applied to perform the susceptibility testing. Quantification of biofilm formation was determined in 96-well microtiter plates as recommended by the defined protocol. The data were then analyzed with SPSS using consensus tables and Chi-square test. Results: Based on the results, all the isolates were positive for invA, sdiA, hilA, and ratA. Moreover, spvC had the lowest prevalence (37.6). Of all strains, 67 were MDR, 51.7 of which were recovered from humans. Furthermore, 34.5 of isolates were strong biofilm producers. There was a significant correlation between the strong biofilm formation and the antibiotic resistance to colistin, ceftazidime, chloramphenicol, gentamicin, trimethoprim, penicillin, and trimethoprim-sulfamethoxazole. Conclusions: The results of the current study showed a significant correlation between the strong biofilm formation and the antibiotic resistance to some antibiotics. Â© 2018, Author(s).
Pengaruh Pemberdayaan Kader Posyandu terhadap Pengetahuan dan Sikap Ibu Balita dalam Pemberian Nutrisi di Posyandu Dusun Tambakrejo Desa Sodo Kecamatan Paliyan Gunungkidul

INTISARI Latar Belakang : Kurangnya pengetahuan dan sikap ibu tentang pemberian nutrisi yang tepat untuk balita menjadi salah satu faktor penyebab masih tingginya masalah gizi balita. Posyandu merupakan sarana untuk memantau tumbuh kembang balita dan menjadi jembatan informasi antara ibu dan petugas kesehatan, namun kurang terampilnya kader dalam memberikan penyuluhan kesehatan menjadi salah satu penyebab kurangnya pengetahuan dan sikap ibu balita dalam pemberian nutrisi. Tujuan : Penelitian ini bertujuan untuk mengetahui pengaruh pemberdayaan kader Posyandu terhadap pengetahuan dan sikap ibu balita dalam pemberian nutrisi di Posyandu Dusun Tambakrejo Desa Sodo Kecamatan Paliyan Gunungkidul. Metode Penelitian : Desain penelitian ini menggunakan Pre – Post Test Design untuk menilai perbedaan tingkat pengetahuan dan sikap ibu balita dalam pemberian nutrisi sebelum dan sesudah pemberdayaan kader Posyandu. Sampel penelitian ini adalah ibu yang memiliki balita di Posyandu Dusun Tambakrejo sebanyak 45 responden dengan tehnik Total Sampling. Analisa data yang digunakan adalah uji Paired Sample T-Test. Hasil penelitian : Hasil menunjukkan bahwa ada perbedaan rata – rata hasil pre dan post- test setelah dilakukan pemberdayaan kader, dengan nilai p sebesar 0.000 < 0.05. Simpulan : Simpulan penelitian ini adalah pemberdayaan kader Posyandu berpengaruh secara bermakna terhadap pengetahuan dan sikap ibu balita dalam pemberian nutrisi di Posyandu Dusun Tambakrejo, Desa Sodo, Kecamatan Paliyan, Gunungkidul. Saran : Petugas kader diharapkan dapat terus belajar dan meningkatkan keterampilan dalam memberikan pelayanan dan melaksanakan seluruh kegiatan di Posyandu. Kata kunci Kepustakaan Jumlah halaman : Pengetahuan dan Sikap, Kader Posyandu, Pemberdayaan : 29 buku (Tahun 2004 – Tahun 2013), 3 jurnal, 2 Skripsi, 20 web : xiv, 89 halaman, 5 tabel, 6 gambar, 18 lampiran
Profiling estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2/neu in breast carcinoma: Study of 111 consecutive cases

Background: Breast cancer is a major health problem for women throughout the world representing nearly a quarter (25%) of all cancers with an estimated 1.67 million new cancer cases diagnosed in 2012. In India, breast cancer is second only to cancer of the cervix among women. It is considered to the be the leading cancer in some cities such as Mumbai and Bangalore. The present study analyzed the pattern of expression of hormone receptor Estrogen receptor (ER), progesterone receptor (PR), and Her-2/neu in invasive breast carcinoma. Materials and Methods: The data for the present study were retrieved from a hospital-based registry of breast cancer established in the department of radiotherapy of a tertiary care center in rural area of North-West India. Records of 111 consecutive patients extending from October 2015 to September 2017 were profiled. Results: One hundred and ten cases were invasive breast carcinoma, not otherwise specify (IDC-NOS). Age of the patients ranged from 30 to 74 years with median age of 48 years. Approximately half of the patients were postmenopausal (n = 58, 52.2%) and left side breast carcinoma was more common (n = 60, 54.1%). Most of the cases belonged to Grade II (n = 60, 54.1%), followed by Grade III (n = 34, 30.6%) with 60 (54.1%) and 48 (43.2%) of cases found in Stage III and II, respectively. ER, PR, human epidermal growth factor receptor 2 (HER2/neu) positive, and triple negative expression were seen in 59 (53.2%), 50 (45.0%), 37 (33.3%), and 31 (27.9%), respectively. Conclusions: Older patients (>50 years) showed higher positivity of ER/PR/HER2 as compared to younger age group, while triple negativity was higher in younger age group.
Looking beyond harm: meaning and purpose of substance use in the lives of marginalized people who use drugs

Abstract Substance use among marginalized populations has historically been constructed as a social problem to be managed, cured, and eliminated. Much social science research concerning drug use among marginalized populations focuses on risks and harms, with little attention to positive aspects of substance use. In this paper we explore positive roles of drugs/drug use among marginalized people who use drugs. We draw on in-depth qualitative interviews conducted with 50 people who use drugs in Vancouver’s Downtown Eastside neighbourhood. Forty-three participants reported positive aspects of drug use. Participant narratives revealed four main themes regarding the role and function of drugs and drug use in their lives: (1) pain relief and management; (2) alleviating mental health issues; (3) fostering social experiences; (4) pleasurable embodied experiences. Our findings show that despite known negative consequences of substance use, in many ways drug use was beneficial for these individuals. Our study demonstrates that given the opportunity, meaningful and useful conversations that shed light on why people take drugs is possible. By understanding why marginalized individuals choose to consume the drugs they do we can begin to engage in truly helpful conversations about how to reduce drug-related harm.