Miracle-dz/UniFAR-FTUs huggingface dataset:
Reliabilities of the Two-Point Discrimination Test and the Two-Point Estimation Test for Use in the Lumbar Spine Area in Healthy Young Adults

Two-point discrimination (TPD) testing and two-point estimation (TPE) methods are often used to determine tactile acuity, but their reliability is uncertain. Our aim in this study was to assess the reliability of TPD and TPE measurements in the same lumbar spine region of healthy young adults. Participants were 37 young adults (16 females and 21 males; age range: 20–27 years – M age = 21.65, SD = 1.9), who received two tests (TPD and TPE) to determine their tactile acuity. The tests were performed in the lumbar spine area, at the level of the L3 segment, bilaterally, with a 10-minute interval between the measurements. The first test session assessed the reliability of measurements performed by two examiners (inter-rater reliability); and, after 7 days, another examiner repeated the measurements (intra-rater reliability). The reliability of both tests was evaluated using intra-class correlation coefficients (ICC), and results revealed high intra-rater, and inter-rater repeatability for immediate administration of TPD and TPE tests (i.e, after 10 minutes) and moderate repeatability when they were performed at a 7-day interval. Thus, we confirmed high reliability of TPD and TPE assessments of tactile acuity repeated at a short time interval and moderate reliability after 7 days. There was slightly higher reliability for the TPE method.
Bidirectional associations of sleep and discretionary screen time in adults: Longitudinal analysis of the UK biobank

The direction of the association between discretionary screen time (DST) and sleep in the adult population is largely unknown. We examined the bidirectional associations of DST and sleep patterns in a longitudinal sample of adults in the general population. A total of 31,361 UK Biobank study participants (52% female, 56.1 ± 7.5 years) had two repeated measurements of discretionary screen time (TV viewing and leisure‐time computer use) and self‐reported sleep patterns (five sleep health characteristics) between 2012 and 2018 (follow‐up period of 6.9 ± 2.2 years). We categorised daily DST into three groups (low, <3 h/day; medium, 3–4 h/day; and high, >4 h/day), and calculated a sleep pattern composite score comprising morning chronotype, adequate sleep duration (7–8 h/day), never or rare insomnia, never or rare snoring, and infrequent daytime sleepiness. The overall sleep pattern was categorised into three groups (healthy: ≥ 4; intermediate: 2–3; and poor: ≤ 1 healthy sleep characteristic). Multiple logistic regression analyses were applied to assess associations between DST and sleep with adjustments for potential confounders. Participants with either an intermediate (OR: 1.40; 95% CI: 1.15, 1.71) or a poor (OR: 1.16; 95% CI: 1.10, 1.24) sleep pattern at baseline showed higher odds for high DST at follow‐up, compared with those with a healthy baseline sleep pattern. Participants with medium (OR: 1.40; 95% CI: 1.14, 1.71) or high DST (OR: 1.62; 95% CI: 1.30, 2.00) at baseline showed higher odds for poor sleep at follow‐up, compared with participants with a low DST. In conclusion, our findings provide consistent evidence that a high DST at baseline is associated with poor sleep over a nearly 7 year follow‐up period, and vice versa.
The Effectiveness of Ketamine Compared to Opioid Analgesics for management of acute pain in Children in The Emergency Department: systematic Review.

AIM The first objective of this systematic review was to investigate the effectiveness of ketamine compared to opioid analgesics for pain management in children aged two months to 18 years who have acute pain in the emergency department. The second objective was to compare the adverse events and side effects associated with ketamine with those associated with opioids used for pain management. BACKGROUND Ketamine is increasingly being used as an alternative to opioids in the management of acute pain in the emergency department. In turn, there is increasing research attention to prove the efficacy of ketamine as an analgesic in children presenting in the emergency department. DESIGN The design was pertinent for gathering and appraisal of evidence presented in the available RCTs. METHODS A systematic review, using the JBI systematic review was completed. A computerised search from five databases; CINAHL, EMBASE, EMCARE and PubMed, and Cochrane. The included studies were appraised by JBI critical appraisal tool for randomized controlled trials and the study results analysed. RESULTS Four randomized control trial studies were included in this systematic review. All the included studies compared ketamine with opioids (morphine and fentanyl) for the management of severe pain in children. The studies were of high methodological quality based on JBI critical appraisal outcome. Meta-analysis was not possible because of the heterogeneity of the studies, especially in terms of different outcome measures, and the approaches (pain assessment tool) used to measure the pain outcomes. The review identified that that ketamine demonstrated non-inferior analgesia effect compared to opioid medication (morphine or fentanyl) as determined by various pain scores used in different studies. However, ketamine use was associated with increased frequency of occurrence of temporary adverse effects that do not require clinical attention. DISCUSSION Ketamine is a suitable alternative for opioid analgesics for the management of acute and severe pain in children in ED. The evidence generated by this study is that ketamine is non-inferior to opioids (morphine and fentanyl) in controlling acute pain in children. CONCLUSION Based on the findings from the review, ketamine is a suitable alternative for opioid analgesics for the management of acute and severe pain in children in ED. The minor transient side effects associated with ketamine should not limit the use of ketamine. Future studies should investigate the appropriate dosage and route of administration of ketamine to be used while managing pain among children with acute and severe pain in the emergency department. IMPLICATIONS FOR NURSING & HEALTH POLICY In this systematic review, the Joanna Briggs Institute standards [14] have been followed. is advisable for the Emergency Department health professionals to determine the appropriate dose for ketamine based on the child's characteristics, such as weight, age, and disease condition.
High HIV/STI prevalence among cisgender men and transgender women sex workers attending community-based centres in Barcelona, Spain: The Sweetie Project

Background The aim of this study was to describe the socio-demographics, and the sexual and health-seeking behaviours of cisgender men and transgender women sex workers (M & TWSW) attending community-based organisations (CBOs) in Barcelona, Spain, as well as to estimate the prevalence of HIV, hepatitis B virus (HBV), hepatitis C virus (HCV), Chlamydia Trachomatis (CT) and Neisseria gonorrhoeae (NG) among them at different anatomical sites. Methods The Sweetie Project was a community-based cross-sectional study of 147 M & TWSW recruited in two CBOs in Barcelona between 2017 and 2018. A nurse collected biological samples from rectum, pharynx and urethra from the subjects at each CBO and the participants self-completed an epidemiological questionnaire. Results The highest prevalence observed was for HIV infection (25.3%) followed by bacterial STIs (NG 19.2% and CT 10.3%). The most prevalent anatomical site was pharyngeal (17.7%) followed by rectal (13.8%). More than half of participants who had a pharyngeal infection presented an isolated pharyngeal infection (57.7%) and half of those who had a rectal or urethral infection presented an isolated infection respectively. The seroprevalence of HCV and HBV was 2.4% and 34.2% respectively. There was a poor but statistically significant correlation between HIV and rectal CT infection (r = 0.31), previous exposure to HCV (r = 0.27) or self-reported STI (r = 0.23), as well as between previous exposure to HCV and rectal CT (r = 0.21) or self-reported STI (r = 0.20). Discussion The Sweetie Project confirms the high burden of HIV and bacterial STIs among a sample of M&TWSW recruited in CBOs and reinforces the need to routinely screen them at all exposed anatomical sites.
Performance comparison of Westergren modified SRS 100/II and alternate iSED® method for erythrocyte sedimentation rate

The erythrocyte sedimentation rate (ESR) includes three phases, each prone to different interferences. Due to many disadvantages of the reference Westergren method, modified and alternate methods have been introduced. The aim of this study was to compare the modified Westergren method on SRS 100/II analyzer in citrate blood with the alternate method on iSED® analyzer in EDTA sample. Additionally, possible interfering factors and ESR stability during 6 h at room temperature were evaluated.
Comparison of Outcomes After Transcatheter Versus Surgical Repeat Mitral Valve Replacement

Introduction Repeat transcatheter mitral valve replacement (rTMVR) has emerged as a new option for the management of high-risk patients unsuitable for repeat surgical mitral valve replacement (rSMVR). The aim of this study was to compare hospital outcomes, survival, and reoperations after rTMVR versus surgical mitral valve replacement. Methods We compared patients who underwent rTMVR (n=22) from 2017 to 2019 (Group 1) to patients who underwent rSMVR (n=98) with or without tricuspid valve surgery from 2009 to 2019 (Group 2). We excluded patients who underwent a concomitant transcatheter aortic valve replacement or other concomitant surgery. Results Patients in Group 1 were significantly older (72.5 [67-78] vs. 57 [52-64] years, P<0.001). There was no diference in EuroSCORE II between groups (6.56 [5.47-8.04] vs. 6.74 [4.28-11.84], P=0.86). Implanted valve size was 26 (26-29) mm in Group 1 and 25 (25-27) mm in Group 2 (P=0.106). There was no diference in operative mortality between groups (P=0.46). However, intensive care unit (ICU) and hospital stays were shorter in Group 1 (P=0.03 and <0.001, respectively). NYHA class improved significantly in both groups at one year (P<0.001 for both groups). There was no group effect on survival (P=0.84) or cardiac readmission (P=0.26). However, reoperations were more frequent in Group 1 (P=0.01). Conclusion Transcatheter mitral valve-in-valve could shorten ICU and hospital stay compared to rSMVR with a comparable mortality rate. rTMVR is a safe procedure; however, it has a higher risk of reoperation. rTMVR can be an option in selected high-risk patients.
Implementation of an Innovative Technology Called the OR Black Box: A Feasibility Study

Introduction. The operating room (OR) Black Box is an innovative technology that captures and compiles extensive real-time data from the OR, allowing identification and analysis of factors that influence intraoperative procedures and performances – ultimately improving patient safety. Implementation of this kind of technology is still an emerging research area and prone to face challenges. Methods. Observational study running from May 2017 to May 2021 conducted at Copenhagen University Hospital – Rigshospitalet, Denmark, involving 152 OR staff and 306 patients. Feasibility of the OR Black Box was assessed in accordance with Bowen’s framework with 8 focus areas. Results. The OR Black Box had a high level of acceptability among stakeholders with 100% participation from management, 93% from OR staff, and 98% from patients. The implementation process improved over time, and an average of 80% of the surgeries conducted were captured. The practical aspects such as numerous formal and informal meetings, ethical and legal approval, recruitment of patients were acceptable, albeit time-consuming. The OR Black Box was adopted without any changes in scheduled surgery program, but capturing hours were adjusted to match the surgery program and relocation of OR staff declining to provide consent was possible. Conclusions. Implementation of the OR Black Box was feasible yet challenging. Management, nearly all staff, and patients embraced the initiative; however, ongoing evaluation, information meetings, and commitment from stakeholders are required and crucial to sustain momentum, continue implementation and expansion. Ideas from this study can be useful in the implementation of similar initiatives.
Microvolt T‐wave alternans in early repolarization syndrome associated with ventricular arrhythmias: A case report

Despite early repolarization (ER) syndrome being usually considered benign, its association with severe/malignant ventricular arrhythmias (VA) was also reported. Microvolt T‐wave alternans (MTWA) is an electrocardiographic marker for the development of VA, but its role in ER syndrome remains unknown. A 90‐second 6‐lead electrocardiogram from an ER syndrome patient, acquired with the Kardia recorder, was analyzed by the enhanced adaptive matched filter for MTWA quantification. On average, MTWA was 50 μV, higher than what was previously observed on healthy subjects using the same method. In our ER syndrome patient, MTWA plays a potential role in VA development in ER syndrome.
Associations between trajectories of obesity prevalence in English primary school children and the UK soft drinks industry levy: An interrupted time series analysis of surveillance data

Background: Sugar sweetened beverages (SSBs) are the primary source of dietary added sugars in children, with high consumption commonly observed in more deprived areas where obesity prevalence is also highest. Associations between SSB consumption and obesity in children have been widely reported. In March 2016, a two-tier soft drinks industry levy (SDIL) on drinks manufacturers to encourage reformulation of SSBs in the UK was announced, and then implemented in April 2018. We examined trajectories in the prevalence of obesity at ages 4-5 years and 10-11 years, 19 months after the implementation of SDIL, overall and by sex and deprivation. Methods and Findings: Data were from the National Child Measurement Programme and included annual repeat cross-sectional measurement of over one million children aged 4-5 and 10-11 years in state-maintained primary schools. Interrupted time series analysis of monthly obesity prevalence data from September 2013 to November 2019 was used to estimate absolute and relative changes in obesity prevalence compared to a counterfactual (adjusted for temporal variations in obesity prevalence) estimated from the trend prior to SDIL announcement. Differences between observed and counterfactual estimates were examined in November 2019 by age (4-5 or 10-11 years) and additionally by sex and deprivation quintile. In 10-11 year old children there was an overall absolute reduction in obesity prevalence (defined as >95th centile on the UK90 growth charts) of 0.8% (95%CI: 0.3, 1.3). In 10-11 year old girls the reduction was 1.6% (95%CI: 1.1, 2.1), with greatest reductions in the two most deprived quintiles (e.g. there was an absolute reduction of 2.4% (95%CI: 1.6, 3.2) in prevalence of obesity in the most deprived quintile). In 10-11 year old boys, there was no change in obesity prevalence, except in the least deprived quintile where there was a 1.6% (95%CI: 0.7,2.5) absolute increase. In 4-5 year old children, relative to the counterfactual, there were overall increases in obesity prevalence in both genders (combined) and all deprivation quintiles except the most deprived where there was no change. Conclusions: Our results suggest the SDIL was associated with decreased prevalence of obesity in 10-11 year old girls, with the greatest effects in those living in the most deprived areas. Additional strategies beyond SSB taxation will be needed to reduce obesity prevalence overall, and particularly in older boys and younger children.
A ternary construction of lattices

In this paper we propose a general ternary construction of lattices from three rows and ternary codes. Most laminated lattices and Kappa lattices in ${\bf R}^n$, $n\leq 24$ can be recovered from our tenary construction naturally. This ternary construction of lattices can be used to generate many new "sub-optimal" lattices of low dimensions.Based on this ternary construction new extremal even lattices of dimensions $32, 40$ and $48$ are also constructed.
Advances in Bayesian Model Based Clustering Using Particle Learning

Recent work by Carvalho, Johannes, Lopes and Polson and Carvalho, Lopes, Polson and Taddy introduced a sequential Monte Carlo (SMC) alternative to traditional iterative Monte Carlo strategies (e.g. MCMC and EM) for Bayesian inference for a large class of dynamic models. The basis of SMC techniques involves representing the underlying inference problem as one of state space estimation, thus giving way to inference via particle filtering. The key insight of Carvalho et al was to construct the sequence of filtering distributions so as to make use of the posterior predictive distribution of the observable, a distribution usually only accessible in certain Bayesian settings. Access to this distribution allows a reversal of the usual propagate and resample steps characteristic of many SMC methods, thereby alleviating to a large extent many problems associated with particle degeneration. Furthermore, Carvalho et al point out that for many conjugate models the posterior distribution of the static variables can be parametrized in terms of [recursively defined] sufficient statistics of the previously observed data. For models where such sufficient statistics exist, particle learning as it is being called, is especially well suited for the analysis of streaming data do to the relative invariance of its algorithmic complexity more » with the number of data observations. Through a particle learning approach, a statistical model can be fit to data as the data is arriving, allowing at any instant during the observation process direct quantification of uncertainty surrounding underlying model parameters. Here we describe the use of a particle learning approach for fitting a standard Bayesian semiparametric mixture model as described in Carvalho, Lopes, Polson and Taddy. In Section 2 we briefly review the previously presented particle learning algorithm for the case of a Dirichlet process mixture of multivariate normals. In Section 3 we describe several novel extensions to the original implementation of Carvalho et al that allow us to retain the computational advantages of particle learning while improving the suitability of the methodology to the analysis of streaming data and simultaneously facilitating the real time discovery of latent cluster structures. Section 4 demonstrates our methodological enhancements in the context of several simulated and classical data sets, showcasing the use of particle learning methods for online anomaly detection, label generation, drift detection, and semi-supervised classification, none of which would be achievable through a standard MCMC approach. Section 5 concludes with a discussion of future directions for research. « less
Individual differences in musical ability among adults with no music training

Good musical abilities are typically considered to be a consequence of music training, such that they are studied in samples of formally trained individuals. Here, we asked what predicts musical abilities in the absence of music training. Participants with no formal music training (N = 190) completed the Goldsmiths Musical Sophistication Index, measures of personality and cognitive ability, and the Musical Ear Test (MET). The MET is an objective test of musical abilities that provides a Total score and separate scores for its two subtests (Melody and Rhythm), which require listeners to determine whether standard and comparison auditory sequences are identical. MET scores had no associations with personality traits. They correlated positively, however, with informal musical experience and cognitive abilities. Informal musical experience was a better predictor of Melody than of Rhythm scores. Some participants (12%) had Total scores higher than the mean from a sample of musically trained individuals (⩾6 years of formal training), tested previously by Correia et al. Untrained participants with particularly good musical abilities (top 25%, n = 51) scored higher than trained participants on the Rhythm subtest and similarly on the Melody subtest. High-ability untrained participants were also similar to trained ones in cognitive ability, but lower in the personality trait openness-to-experience. These results imply that formal music training is not required to achieve musician-like performance on tests of musical and cognitive abilities. They also suggest that informal music practice and music-related predispositions should be considered in studies of musical expertise.
Toward Network Intelligence

Abstract This article proposes a conceptual framework to guide research in neural computation by relating it to mathematical progress in other fields and to examples illustrative of biological networks. The goal is to provide insight into how biological networks, and possibly large artificial networks such as foundation models, transition from analog computation to an analog approximation of symbolic computation. From the mathematical perspective, I focus on the development of consistent symbolic representations and optimal policies for action selection within network settings. From the biological perspective, I give examples of human and animal social network behavior that may be described using these mathematical models.
Comparison of single-lead and multi-lead ECG for QT variability assessment using autoregressive modelling

Objective. Beat-to-beat fluctuations in the QT interval—QT variability (QTV)—have been shown to vary amongst the different ECG leads. This study aims to compare the utility of single and multi-lead ECG to disentangle the mechanisms contributing to QTV. Approach. Twelve-lead ECG was analysed in 57 coronary artery disease patients before and after an elective percutaneous transluminal coronary angiography (PTCA) procedure. QT, RR and respiration time series were extracted. QTV was decomposed into contributions by heart rate, respiration and QTV independent of heart rate and respiration using parametric autoregressive modelling. Signal-to-noise ratio, model goodness-of-fit, mean QT, corrected QT, QT variability and RR variability were also computed. Results from two single leads (Lead II and V5) and three one-dimensional representations of 12-lead ECG (principal component analysis (PCA), vector magnitude (VM), and root mean square of the 8 independent leads of the standard 12 leads (RMS8)) were compared during resting conditions, before and after PTCA, and between patients with myocardial infarction and those without. Main results. At baseline, mean QT and corrected QT were significantly lower in VM and RMS8 compared to single leads. While overall QT variability was not different between the leads, QT independent of heart rate and respiration was significantly lower in VM and RMS8. Following PTCA, changes in these variables were similar in all leads. Differences between patients with MI and those without MI were consistent in all leads. Significance. Despite the differences in some QTV components amongst various leads, single-lead ECG could be sufficient for analyzing QTV in populations with pathological cardiovascular conditions compared to those without, or for quantification of intervention effects.