Miracle-dz/UniFAR-FTUs huggingface dataset:
Assessing Forest Vitality and Forest Structure Using 3D Data: A Case Study From the Hainich National Park, Germany

The adaptation of forest management to changing environmental conditions due to climate change relies on information on the current forest and tree vitality. In common practice, the percentage of crown defoliation is used as a proxy for tree vitality, an approach that has several drawbacks. By performing laser scanning on a forest plot in the Hainich National Park, we tested a new approach to quantifying tree vitality. Based on the difference in structural complexity measured between summer and winter, assessed via the box-dimension, the new approach provides an objective and reproducible method that does not only allow the quantification of the defoliation, but also includes the effects of branch diebacks. In addition, we assessed the change in box-dimension and branch lengths between 2013 and 2021 and studied the overall structural development of the trees to analyze the alteration of their vitality. On average, we found a decrease in overall structural complexity, as well as in branch lengths for most trees in the investigated forest. Further, the mean difference in box-dimension (summer minus winter) decreased with ascending vitality class. We conclude that the vitality of the trees was negatively affected over the period of 8 years, and we argue the newly proposed method based on the box-dimension holds potential to be used as a measure for tree vitality in deciduous forests.
Polyphenolic and Chemical Profiles of Honey From the Tara Mountain in Serbia

This study presents a detailed characterization of 27 honey samples from the Tara Mountain region in Serbia using different comprehensive techniques and methods. The types of the honey samples were defined as monofloral (4 samples), honeydew (5 samples) and polyfloral (18 samples) honey based on determined polyphenol content, antioxidant activity, electrical conductivity and melissopalynological analyses. Physicochemical parameters such as pH (4.13–4.94), diastase activity (24.20–41.70 DN), acidity (14.60–29.70 meq/kg), content of 5-(hydroxymethyl)furfural (in range below 5, up to 16.90 mg/kg), sucrose (0.20–3.90 g/100 g), and moisture content (15.01–19.23%) confirmed the required quality of the honey samples. Sensory analysis revealed honey characteristics favorable to consumers. Analyses of 19 phenolic compounds using ultra-high-performance liquid chromatography with a diode-array detection and triple quadrupole mass spectrometry (UHPLC-DAD-MS/MS) revealed six phenolic acids and 13 other compounds from the group of flavonoids and their glycosides. In all the samples the highest content was determined for p-coumaric acid, followed by caffeic acid and pinocembrin. Besides total phenolic content and radical scavenging activity, antimicrobial activity was also examined. Most honey samples showed bactericidal activity against Staphylococcus aureus and bacteriostatic activity against Escherichia coli, while none of the honey samples inhibited the growth of Candida albicans. Chemometric analyses were applied for an in-depth study of the results to further evaluate the characteristics of the honey samples studied. Principal component analysis (PCA) was used for assessing the differences in physicochemical parameters, polyphenols content and antioxidant capacity between honey samples. The unrooted cluster tree was used to group the samples based on the melissopalynological analyses.
The Prevalence of Klebsiella spp. Associated With Bovine Mastitis in China and Its Antimicrobial Resistance Rate: A Meta-Analysis

Understanding distribution of bovine mastitis pathogen Klebsiella spp. can contribute to the treatment decision and the control within programs of bovine mastitis, we conducted a meta-analysis to investigate the epidemiology and antimicrobial resistance rates of Klebsiella spp. associated with bovine mastitis in China. Three databases, namely, PubMed, Google scholar, and China National Knowledge Infrastructure database, were utilized to obtain relevant publications. According to PRISMA reporting standards, a total of 38 publications were included in the research, among them, 7 papers included an AMR test. The pooled prevalence of Klebsiella spp. was 5.41% (95% CI: 3.87–7.50%). Subgroup analysis revealed that the prevalence was higher in South China (8.55%, 95% CI: 3.57–19.09%) than in North China (4.22%, 95% CI: 2.46–7.14%), in 2010–2020 (7.45%, 95% CI: 5.29–110.40%) than in 2000–2010 (3.14%, 95% CI: 1.90–15.14%), and in the clinical bovine mastitis cases (7.49%, 95% CI: 3.71–14.54%) than in the subclinical cases (4.03%, 95% CI: 1.55–10.08%). The pooled AMR rate revealed that Klebsiella spp. were most resistant to sulfonamides (45.07%, 95% CI: 27.72–63.71%), followed by tetracyclines (36.18%, 95% CI: 23.36–51.34%), aminoglycosides (27.47%, 95% CI: 17.16–40.92%), β-lactams (27.35%, 95% CI: 16.90–41.05%), amphenicol (26.82%, 95% CI: 14.17–44.87%), lincosamides (21.24%, 95% CI: 7.65–46.75%), macrolides (20.98%, 95% CI: 7.20–47.58%), polypeptides (15.51%, 95% CI: 6.46–32.78%), and quinolones (7.8%, 95% CI: 3.25–17.56%). The climate difference between South and North China and the natural pathogenicity of Klebsiella spp. may be the primary reasons for its distribution, and the prevalence of Klebsiella spp. indicated that the genus is an increasing hazard to the dairy industry. The prevalence of AMR in China is commonly higher than in the European countries and Canada, this is a very important concern for strategy programs to control bovine mastitis caused by Klebsiella spp. in China.
High Definition Three-Dimensional Exoscope (VITOM 3D) in E.N.T. Surgery: A Systematic Review of Current Experience

Over the last decade, technological growth has developed new devices for more precise surgery based on improved maneuverability, minimally invasive approaches, and magnification of the operating field. In this context, the exoscope has opened a new phase for more accurate and safer microsurgery, improving the perception of the volume of objects and the depth of structures for planning, targeting, and controlling fine movements. The exoscope could be used for middle ear, transcanal, transmastoid, and craniotomy procedures that require two-handed dissection, both to perform both totally VITOM-based techniques and coupled to traditional procedures with an operating microscope or endoscope. In addition, the VITOM 3D system allows the surgeon to work with high-definition images, which is essential in facial nerve surgery or submandibular salivary stone or tear surgery approaches, where magnification plays a fundamental role in surgical success and in reducing operating times. The 3D exoscope approach could also be included in traditional transoral procedures for oropharyngeal carcinoma. The exoscope may provide a relevant approach in teaching surgeons and nurses, allowing adequate training in non-oncological surgical procedures such as a tonsillectomy or lateral pharyngoplasty.
Potential for Energy Utilization of Air Compression Section Using an Open Absorption Refrigeration System

In this paper, an open absorption refrigeration system is proposed to recover part of the waste compression heat while producing cooling capacity to further cool the compressed air itself. The self-utilization of the compression waste heat can significantly reduce the energy consumption of air compression, and hence increase the energy efficiency of the cryogenic air separation unit. To illuminate the energy distribution and energy conversion principle of the open absorption refrigerator-assisted air compression section, a thermodynamic model is built and the simulation work conducted based on a practical triple-stage air compression section of a middle-scale cryogenic air separation unit. Our results indicate that the energy saving ratio is mainly constrained by the distribution of the cooling load of compressed air, which corresponds to the heat load of the generator and cooling capacity of the evaporator in the open absorption refrigerator. The energy saving ratio ranges from 0.52–8.05%, corresponding to the temperature range of 5–30 °C and humidity range of 0.002–0.010 kg/kg. It is also estimated, based on the economic analysis, that the payback period of the open absorption refrigeration system is less than one year, and the net project revenue during its life cycle reaches USD 5.7 M, thus showing an attractive economic potential.
Task level motion planning : integrating local robot control and global sampling

This thesis addresses the problem of generating goal-directed movements for robots, a challenging problem especially in cases where the involved state spaces are high-dimensional and complex constraints, such as obstacles and joint-limits, are present. Local methods can be severely hindered in such situations and planning on a global level becomes necessary. Although an exhaustive search of the state space can generally solve these problems, complete planning methods do not scale well with the number of dimensions. To avoid the inherent complexity of complete state space planning, this work proposes the use of a condensed task- centered representation, focusing on the task to be achieved and neglecting all unnecessary details. The motion planning problem can then be effectively decomposed into two layers: A global search component that is restricted to the coarse-scale task representation and a local control method that generates fine-scale motions. The ability of the approach to solve difficult planning problems is demonstrated with an application for redundant robotic manipulators. Due to the limitation of global planning to the task representation, completeness can no longer be guaranteed, but it can be shown that many relevant situations can be solved. In particular, the ability to solve planning tasks for a humanoid robot operating in human-centered environments is demonstrated in both simulation and laboratory experiments, providing evidence of a significant computational advantage compared to complete state space sampling methods.
Relationship between sleep pattern and bone mineral density in patients with osteoporotic fracture

Background: Evidence investigating sleep pattern in relation to bone health in elderly participants with osteoporosis remains sparse. We aimed to assess the relationship between sleep pattern incorporating five sleep characteristics (snoring, midnight waking up, insomnia, sleep duration, and daytime napping) and bone mineral density (BMD) in elderly participants with osteoporotic fracture. Methods: A cross-sectional study was conducted to include eligible elderly patients from the Department of Orthopedics who were admitted to hospital due to an osteoporotic fracture. Sleep pattern was constructed based on total sleep scores and categorized into healthy, intermediate, and poor pattern groups. Multivariable logistic regression model was used to assess sleep pattern in relation to risk of low BMD. Results: A total of 169 elderly patients with osteoporotic fracture were included in this study (mean age: 71.91 years; 87.57% females). There were 36 (21.30%), 107 (63.31%), and 26 (15.38%) patients with healthy, intermediate, and poor sleep pattern, respectively. Compared with healthy sleep pattern, no significant relationship between intermediate sleep pattern and BMD was detected [odds ratio (OR) = 1.72, 95% confidence interval (CI): 0.74, 3.97, p = 0.21), while poor pattern was significantly associated with decreased BMD (OR = 3.50, 95% CI: 1.10, 11.14, p = 0.034). Conclusion: The majority of elderly patients with osteoporotic fracture had unhealthy sleep pattern; poor sleep pattern was significantly related to reduced BMD when compared with healthy pattern. Further high-quality evidence is needed to assess and validate the relationship between sleep pattern and risk of low BMD in the elderly.
Comparison of effectiveness and postoperative complications of different surgical methods in the treatment of benign prostatic hyperplasia: a systematic review and meta-analysis based on randomized controlled trials

Background More and more new surgical procedures for the treatment of benign prostate hyperplasia (BPH) are proposed creatively. However, the existing clinical evidence shows that the effectiveness and safety of various procedures exist inconsistent. Methods The randomized controlled trials comparing the international prostate score, length of hospital stay, maximum urinary flow rate, operation time, and complication rates of prostatic artery embolization (PAE), Greenlight-XPS Laser prostate vaporization procedure (GLL PVP), diode laser enucleation of prostate (DILEP) and plasmakinetic resection of the prostate (PKRP), transurethral resection of the prostate (TURP) in patients with BPH were screened out in databases. The primary outcome was pooled using a restricted maximum likelihood-based random-effect model and inverse variance-based fixed-effect model. Cochrane Q statistics and I2 statistics were computed to quantify between-study heterogeneity. The risk of bias of each included study was assessed using the revised Cochrane risk of bias tool. Results This meta-analysis ultimately included 14 original research papers, with 1,940 participants enrolled. Eight studies were considered to be at moderate risk of bias, while the others were at mild risk of bias. Although the improvement in functional outcome of the DILEP procedure was equivalent to that of the PKRP procedure, the DILEP procedure group had fewer hospital stays than the PKRP group (P=0.01). In addition, even though the performance of the GLL PVP procedure in the improvement of functional outcome was inferior to the counterpart of TURP (P=0.64), it had a much fewer hospital stays (P=0.01). Moreover, there is still insufficient evidence for the improvement of subjective functional indicators of postoperative patients with PAE compared with TURP [international prostate symptom score (IPSS): P=0.73; IPSS QoL: P=0.91], but achieved less satisfactory objective functional outcomes (Qmax: P=0.06; PVR: P=0.00). Discussion New surgical procedures such as GLL PVP, PAE, and DILEP were safer than traditional TURP procedures. However, it is not superior to traditional surgery in the improvement of clinical symptoms. In clinical practice, the pros and cons of the new operation and the traditional operation should be carefully weighed, and the operation that is most suitable for the patient's condition should be selected.
Energy Embedded in Food Loss Management and in the Production of Uneaten Food: Seeking a Sustainable Pathway

Recently, important efforts have been made to define food loss management strategies. Most strategies have mainly been focused on mass and energy recovery through mixed food loss in centralised recovery models. This work aims to highlight the need to address a decentralised food loss management, in order to manage the different fractions and on each of the different stages of the food supply chain. For this purpose, an energy flow analysis is made, through the calculation of the primary energy demand of four stages and 11 food categories of the Spanish food supply chain in 2015. The energy efficiency assessment is conducted under a resource use perspective, using the energy return on investment (EROI) ratio, and a circular economy perspective, developing an Energy return on investment – Circular economy index (EROIce), based on a food waste-to-energy-to-food approach. Results suggest that the embodied energy loss consist of 17% of the total primary energy demand, and related to the food categories, the vegetarian diet appears to be the most efficient, followed by the pescetarian diet. Comparing food energy loss values with the estimated energy provided for one consumer, it is highlighted the fact that the food energy loss generated by two to three persons amounts to one person's total daily intake. Moreover, cereals is the category responsible for the highest percentage on the total food energy loss (44%); following by meat, fish and seafood and vegetables. When the results of food energy loss and embodied energy loss are related, it is observed that categories such as meat and fish and seafood have a very high primary energy demand to produce less food, besides that the parts of the food supply chain with more energy recovery potential are the beginning and the end. Finally, the EROIce analysis shows that in the categories of meat, fish and seafood and cereals, anaerobic digestion and composting is the best option for energy recovery. From the results, it is discussed the possibility to developed local digesters at the beginning and end of the food supply chain, as well as to developed double digesters installations for hydrogen recovery from cereals loss, and methane recovery from mixed food loss.
Dinutuximab Beta in Children with High-Risk Neuroblastoma: Experience from a Single Center in Croatia

To determine the potential benefits and feasibility of administering maintenance therapy with dinutuximab beta for high-risk neuroblastoma (HRNB) in clinical practice, a retrospective review of charts of patients with HRNB treated at a single center in Croatia (2012–2021) was undertaken. Of 23 patients with HRNB, 11 received up to five cycles of dinutuximab beta as part of multimodal therapy; 12 patients did not (i.e., no immunotherapy). In the no immunotherapy group, one patient had complete remission (8%), and 11 patients died of tumor progression (92%). In the dinutuximab beta group, eight patients had complete remission (73%; median duration of response 5 years and 2 months), one had stable disease (9%), and two died of disease (18%). Patients who received dinutuximab beta had a higher median event-free survival (40.0 months [range: 12.5–83.0]) and median overall survival (56.0 months [range: 16.2–101.0]) than those who did not (12.9 months [range: 3.3–126.0] and 20.7 months [3.3–126.0], respectively). Dinutuximab beta was generally well tolerated; adverse events were manageable and as reported in clinical studies. These results confirm the benefits and feasibility of maintenance therapy with dinutuximab beta as part of multimodal therapy for patients with HRNB in real-world clinical practice.
Human IL12p80 Promotes Murine Oligodendrocyte Differentiation to Repair Nerve Injury

Nerve injury of the central nervous system and the peripheral nervous system still poses a major challenge in modern clinics. Understanding the roles of neurotrophic factors and their molecular mechanisms on neuro-regeneration will not only benefit patients with neural damage but could potentially treat neurodegenerative disorders, such as amyotrophic lateral sclerosis. In this study, we showed that human IL12 p40-p40 homodimer (hIL12p80) within PLA and PLGA conduits improved sciatic nerve regeneration in mice. As such, the group of conduits with NSCs and hIL12p80 (CNI) showed the best recovery among the groups in the sciatic functional index (SFI), compound muscle action potential (CMAP), and Rotarod performance analyses. In addition, the CNI group had a faster recovery and outperformed the other groups in SFI and Rotarod performance tests beginning in the fourth week post-surgery. Immunohistochemistry showed that the CNI group increased the diameter of the newly regenerated nerve by two-fold (p < 0.01). In vitro studies showed that hIL12p80 stimulated differentiation of mouse NSCs to oligodendrocyte lineages through phosphorylation of Stat3 at Y705 and S727. Furthermore, implantation using PLGA conduits (C2.0 and C2.1) showed better recovery in the Rotarod test and CMAP than using PLA conduits in FVB mice. In B6 mice, the group with C2.1 + NSCs + hIL12p80 (C2.1NI) not only promoted sciatic functional recovery but also reduced the rate of experimental autotomy. These results suggested that hIL12p80, combined with NSCs, enhanced the functional recovery and accelerated the regeneration of damaged nerves in the sciatic nerve injury mice. Our findings could further shed light on IL12′s application not only in damaged nerves but also in rectifying the oligodendrocytes’ defects in neurodegenerative diseases, such as amyotrophic lateral sclerosis and multiple sclerosis.
Deciphering the myth of icariin and synthetic derivatives in improving erectile function from a molecular biology perspective: a narrative review

Background and Objective Although epimedium herb (EH) has been widely used in ancient Chinese medicine to enhance sexual activity, its pharmacological mechanism is not clear. Modern studies have shown that epimedium herb is rich in icariin (ICA, a flavonoid compound), and 91.2% of icariin is converted to icariside II (ICA II) by hydrolytic enzymes in intestinal bacteria after oral administration. YS-10 is a synthetic derivative of icariside II. The aim of this review was to summarize the contemporary evidence regarding the pharmacokinetics, therapeutic properties, and molecular biological mechanisms of ICA and some ICA derivatives for erectile dysfunction therapy. Methods A detailed search was conducted in the PubMed database using keywords and phrases, such as “icariin” AND “erectile dysfunction”, “icariside II” AND “erectile dysfunction”. The publication time is limited to last 20 years. Articles had to be published in peer reviewed journals. Key Content and Findings ICA and its some derivatives showed the specific inhibition on phosphodiesterase type 5 (PDE5) and the promotion of testosterone synthesis. In addition, by regulating various reliable evidence of signaling pathways such as PI3K/AKT, TGFβ1/Smad2, p38/MAPK, Wnt and secretion of various cytokines, ICA and ICA derivatives can activate endogenous stem cells (ESCs) leading to endothelial cell and smooth muscle cell proliferation, nerve regeneration and fibrosis inhibition, repair pathological changes in penile tissue and improve erectile function. Conclusions ICA and some of its derivatives could be a potential treatment for restoring spontaneous erections. In addition ICA and his derivatives may also be valuable as a regenerative medicine approach for other diseases, but more clinical and basic researches with high quality and large samples are recommended.
Fuzzy-Assisted Mobile Edge Orchestrator and SARSA Learning for Flexible Offloading in Heterogeneous IoT Environment

In the era of heterogeneous 5G networks, Internet of Things (IoT) devices have significantly altered our daily life by providing innovative applications and services. However, these devices process large amounts of data traffic and their application requires an extremely fast response time and a massive amount of computational resources, leading to a high failure rate for task offloading and considerable latency due to congestion. To improve the quality of services (QoS) and performance due to the dynamic flow of requests from devices, numerous task offloading strategies in the area of multi-access edge computing (MEC) have been proposed in previous studies. Nevertheless, the neighboring edge servers, where computational resources are in excess, have not been considered, leading to unbalanced loads among edge servers in the same network tier. Therefore, in this paper, we propose a collaboration algorithm between a fuzzy-logic-based mobile edge orchestrator (MEO) and state-action-reward-state-action (SARSA) reinforcement learning, which we call the Fu-SARSA algorithm. We aim to minimize the failure rate and service time of tasks and decide on the optimal resource allocation for offloading, such as a local edge server, cloud server, or the best neighboring edge server in the MEC network. Four typical application types, healthcare, AR, infotainment, and compute-intensive applications, were used for the simulation. The performance results demonstrate that our proposed Fu-SARSA framework outperformed other algorithms in terms of service time and the task failure rate, especially when the system was overloaded.