Miracle-dz/UniFAR-FTUs huggingface dataset:
Prevalence of stress urinary incontinence and its impact on quality of life among women in Jordan: a correlational study

Objective The study investigated the prevalence and impact of stress urinary incontinence (SUI) among women in Jordan. Methods A correlational study was conducted to evaluate 500 Jordanian women aged >20 years. Women with symptoms of dementia, delirium, neurodegenerative changes and osteodegenerative changes were excluded. Data were collected using self-administered questionnaires (Arabic version of the Urogenital Distress Inventory-6 and Incontinence Impact Questionnaire (IIQ-7) short forms). Results A total of 200 (40%) women reported SUI; 47% reported mild symptoms, 37% reported moderate symptoms and 16% reported severe symptoms. There were positive correlations between SUI prevalence and number of pregnancies, age and obesity. SUI had a substantial impact on all aspects of quality of life (QoL), as assessed by the IIQ-7. Conclusions A moderate prevalence of SUI was reported. There was a significant association between development of SUI and age, higher body mass index and number of pregnancies. Because SUI is highly prevalent and has a major effect on QoL, healthcare professionals should inquire about this condition and refer patients to related specialties for treatment.
The calanoid copepod Acartia italica Steuer, phenomenon in the small saline Lake Rogoznica (Eastern Adriatic coast)

Lake Rogoznica, near Sibenik, Croatia, is a salt coastal lake with a maximum depth of about 15 m. During most of the year, this small, naturally eutrophied lake is highly stratified, with hypoxia/anoxia occurring in the bottom layer. Total anoxia, with the presence of hydrogen sulphide, was recorded on September 27, 1997. At that moment, massive mortality of all planktonic and benthic organisms was observed. After the anoxia, Acartia italica, the only planktonic copepod species of the lake, re-established quickly. Before anoxia, the population dynamics of the A.italica population depended primarily on predator/prey relationships. However, in the post-anoxic period, nutrient-phytoplankton-copepod relationships became more important, as there was no longer any predation pressure. From all accounts, it would appear that only A.italica is adapted to the extreme conditions which appear from time to time in the lake, and that this species has an important role in the functioning of the lake ecosystem. Acartia italica was very important for the gradual normalization of life in the lake after total anoxia.
Crohn Disease Arthropathy: Antigens in Synovial Fluid Share Epitopes with Strains of Two Species of Viridans Streptococci

Background: There is evidence to suggest that Crohn disease is caused by an immunologic response to an unknown intestinal luminal antigen, probably of bacterial origin. The reported demonstration of yersinia antigen in the synovial fluid of patients with yersinosis therefore prompted a search for bacterial antigens in the synovial fluid of patients with Crohn arthropathy. Methods: Antisera were raised in rabbits to synovial fluids obtained from seven patients with Crohn arthropathy and from seven 'control' subjects with other forms of arthropathy. These antisera were used to probe sonicates of the bacteria cultured from the gastric juice of patients with gastric Crohn disease. Results: The antisera made from the Crohn synovial fluids, but none of those made from the controls, reacted uniquely with antigens in sonicates of strains of two species of viridans streptococci (Streprococcus parasanguis and an atypical S. oralis) isolated from four of the five patients with gastric Crohn disease. Conclusions: These findings suggest that the arthropathy of Crohn disease and, possibly, the intestinal disease itself may involve an immunologically mediated inflammatory response to these antigens.
Optimization of GPU-based Sparse Matrix Multiplication for Large Sparse Networks

Sparse matrix multiplication (spGEMM) is widely used to analyze the sparse network data, and extract important information based on matrix representation. As it contains a high degree of data parallelism, many efficient implementations using data-parallel programming platforms such as CUDA and OpenCL have been introduced on graphic processing units (GPUs). Several well-known spGEMM techniques, such as cuS- PARSE and CUSP, often do not utilize the GPU resources fully, owing to the load imbalance between threads in the expansion process and high memory contention in the merge process. Furthermore, even though several outer-product-based spGEMM techniques are proposed to solve the load balancing problem on expansion, they still do not utilize the GPU resources fully, because severe computation load variations exist among the multiple thread blocks.To solve these challenges, this paper proposes a new optimization pass called Block Reorganizer, which balances the total computations of each computing unit on target GPUs, based on the outer-product-based expansion process, and reduces the memory pressure during the merge process. For expansion, it first identifies the actual computation amount for each block, and then performs two thread block transformation processes based on their characteristics: 1) B-Splitting to transform a heavy-computation blocks into multiple small blocks and 2) B- Gathering to aggregate multiple small-computation blocks to a larger block. While merging, it improves the overall performance by performing B-Limiting to limit the number of blocks on each computing unit. Experimental results show that it improves the total performance of kernel execution by 1.43x, on an average, when compared to the row-product-based spGEMM, for NVIDIA Titan Xp GPUs on real-world datasets.
Recovery Over Time and Prognostic Factors in Treated Patients with Post-Infectious Olfactory Dysfunction: A Retrospective Study

Objectives: The aims of the present study were to clarify the time-course of olfactory recovery and the prognostic factors in PIOD patients treated with Toki-shakuyaku-san (TSS). Methods: A retrospective cohort study of patients with PIOD was conducted by reviewing patients’ medical records. This study included patients who received TSS or a combination of TSS and zinc sulfate. Olfactory function was examined by T&T olfactometer at each 3-monthly follow-up visit. Patients with normal and mild olfactory dysfunction were excluded. Gender, age, treatment, duration of disease until the first visit and olfactory function scores of the T&T olfactometer at the first visit were analyzed as candidate clinical predictors of recovery. Results: A total of 82 PIOD patients with ages ranging from 16 to 79 years were included. The mean duration of follow-up was 14.5 months (range 3-45 months). The number of patients with olfactory recovery increased for 24 months and the cumulative recovery rate was 77.3%. In about 60% of patients, olfactory recovery occurred within 6 months. Multivariate analysis showed that younger age (<65 years) and residual olfactory function were significantly associated with good olfactory recovery. Conclusions: We revealed recovery rates over time in patients with PIOD. The recovery of olfactory function often occurred during the early period (≤6 months). However, the number of patients with olfactory recovery increased for a long-term of 24 months after the first visit. Residual olfactory function and younger age were prognostic factors exactly. TSS may be a useful therapeutic agent for patients with PIOD. We believe that these results provide important information that is useful for counseling patients with PIOD.
Speeding Up GED Verification for Graph Similarity Search

Graph similarity search retrieves from a database all graphs whose edit distance (GED) to a query graph is within a threshold. As GED computation is NP-hard, the existing works adopt the filtering-and-verification paradigm to reduce the number of GED verifications, and they mainly focus on designing filtering techniques while using the now out-dated algorithm A∗GED for verification. In this paper, we aim to speed up GED verification, which is orthogonal to the index structures used in the filtering phase. We propose a bestfirst search algorithm AStar+-LSa which improves A∗GED by (1) reducing memory consumption, (2) tightening lower bound estimation, and (3) improving the time complexity for lower bound computation. We formally show that AStar+-LSa has a lower space and time complexity than A∗GED. We further modify AStar+-LSa into a depth-first search algorithm to contrast these two search paradigms, and we extend our algorithms for exact GED computation. We conduct extensive empirical studies on real graph datasets, and show that our algorithm AStar+-LSa outperforms the state-of-the-art algorithms by several orders of magnitude for both GED verification and GED computation.
Lipid and protein changes in chilled sea salmon (Pseudopercis semifasciata): effect of previous rosemary extract (Rossmarinus officinalis L.) application

Summary The aim of this work was to analyse the effect of rosemary extract application (200 and 500 ppm) on lipid oxidation, colour and protein modifications during the chilled storage (1.0 ± 0.7 °C) of sea salmon (Pseudopercis semifasciata). Lipid oxidation and ω3-22:6 fatty acid content modification were prevented by the addition of rosemary extract. Analysis of interaction between lipid oxidation products and proteins by fluorescence showed no relationship between their temporal changes in the aqueous phase and the lipid oxidation evolution since a similar behaviour was observed in both absence and presence of antioxidant. Protein extractability, sodium dodecyl sulphate-polyacrylamide gel electrophoresis, differential scanning calorimetry and lysine content determinations revealed no differences between muscle untreated or treated with rosemary. Fluorescent compounds evolution in organic phase would be in relation with the appearance of lipid oxidation products. In addition, rosemary extract partially prevented the loss of red colour in chilled muscle. Although protein alterations could not be prevented, rosemary extract shows to be a promissory antioxidant in sea salmon muscle.
Survival of Escherichia Coli O157:H7 During Storage of Yogurt at Different Temperatures

: The behavior of E. coli O157:H7 strains during the storage of plain live yogurt at 4, 8, 17, and 22 °C was investigated. Lactic acid bacteria and pH were also studied. Linear regression analysis was carried out to obtain the specific death rate, the death rate and time of death. During the 1st 24 h, the pathogenic strains decreased slightly at 4 and 8 °C. This decrease was greater at 17 °C, and even greater at 22 °C. E. coli O157:H7 was not detected after 312, 168, 28, and 16 h at 4, 8, 17, and 22 °C, respectively. Counts of Lactobacillus and Streptococcus were about 9 log CFU/g during the study. An increase was detected in the values for time of death from refrigeration to room temperatures. A decrease in the values of both the specific death rate and the death rate related with the increase of temperature was observed. Counts of E. coli O157:H7 were higher than those of non-pathogenic E. coli during the storage period at 4 and 8 °C, showing a better and a higher adaptation capacity to acid pH environments at refrigeration temperatures. This behavior was not observed at room temperatures.
Membrane-tethered mucin-like polypeptides sterically inhibit binding and slow fusion kinetics of influenza A virus

Significance Influenza A viruses cause tens of millions of cases of seasonal flu each year. Before a virus infects a host cell, it must first pass through a dense forest of sugar-bearing proteins called mucins. The basic mechanisms of how the virus navigates and chops down this forest of mucins remain up for debate, and many flu drugs target the interactions of the virus with mucin-like proteins. In this work, we make synthetic versions of mucins to create an artificial forest that can be tuned and modified at a molecular level to study how mucins impact influenza A virus binding and fusion. The mechanism(s) by which cell-tethered mucins modulate infection by influenza A viruses (IAVs) remain an open question. Mucins form both a protective barrier that can block virus binding and recruit IAVs to bind cells via the sialic acids of cell-tethered mucins. To elucidate the molecular role of mucins in flu pathogenesis, we constructed a synthetic glycocalyx to investigate membrane-tethered mucins in the context of IAV binding and fusion. We designed and synthesized lipid-tethered glycopolypeptide mimics of mucins and added them to lipid bilayers, allowing chemical control of length, glycosylation, and surface density of a model glycocalyx. We observed that the mucin mimics undergo a conformational change at high surface densities from a compact to an extended architecture. At high surface densities, asialo mucin mimics inhibited IAV binding to underlying glycolipid receptors, and this density correlated to the mucin mimic’s conformational transition. Using a single virus fusion assay, we observed that while fusion of virions bound to vesicles coated with sialylated mucin mimics was possible, the kinetics of fusion was slowed in a mucin density-dependent manner. These data provide a molecular model for a protective mechanism by mucins in IAV infection, and therefore this synthetic glycocalyx provides a useful reductionist model for studying the complex interface of host–pathogen interactions.
Migratory behavior and winter geography drive differential range shifts of eastern birds in response to recent climate change

Significance Over the past half century, populations of neotropical migratory birds in North America have plummeted while populations of resident species have largely remained stable. We show that resident and migratory birds in eastern North America have responded differently to climate change over this period, with the ranges of resident species expanding along their northern margin while the ranges of migratory species have contracted at their southern margin. These results suggest that the ability to colonize newly suitable areas may make resident species resilient to future climate change but that climate-induced range contractions may make neotropical migrants vulnerable to these changes. Over the past half century, migratory birds in North America have shown divergent population trends relative to resident species, with the former declining rapidly and the latter increasing. The role that climate change has played in these observed trends is not well understood, despite significant warming over this period. We used 43 y of monitoring data to fit dynamic species distribution models and quantify the rate of latitudinal range shifts in 32 species of birds native to eastern North America. Since the early 1970s, species that remain in North America throughout the year, including both resident and migratory species, appear to have responded to climate change through both colonization of suitable area at the northern leading edge of their breeding distributions and adaption in place at the southern trailing edges. Neotropical migrants, in contrast, have shown the opposite pattern: contraction at their southern trailing edges and no measurable shifts in their northern leading edges. As a result, the latitudinal distributions of temperate-wintering species have increased while the latitudinal distributions of neotropical migrants have decreased. These results raise important questions about the mechanisms that determine range boundaries of neotropical migrants and suggest that these species may be particularly vulnerable to future climate change. Our results highlight the potential importance of climate change during the nonbreeding season in constraining the response of migratory species to temperature changes at both the trailing and leading edges of their breeding distributions. Future research on the interactions between breeding and nonbreeding climate change is urgently needed.
MicroRNA Signature of Epithelial-Mesenchymal Transition in Group B Streptococcal Infection of the Placental Chorioamniotic Membranes.

BACKGROUND Infection-induced preterm birth is a major cause of neonatal mortality and morbidity and leads to preterm premature rupture of the placental chorioamniotic membranes. The loss of amniotic epithelial cells and tensile strength preceding membrane rupture is poorly understood. We hypothesized that intrauterine bacterial infection induces changes in microRNA (miRNA) expression, leading to amniotic epithelial cell loss and membrane weakening. METHODS Ten pregnant pigtail macaques received choriodecidual inoculation of either Group B Streptococcus (GBS) or saline (N=5/group). Placental chorioamniotic membranes were studied using RNA microarray and immunohistochemistry. Chorioamniotic membranes from women with preterm premature rupture of membranes (pPROM) and normal term pregnancies was studied using transmission electron microscopy. RESULTS In our model, an experimental GBS infection was associated with changes in the miRNA profile in the chorioamniotic membranes consistent with epithelial to mesenchymal transition (EMT) along with loss of epithelial (E-cadherin) and gain of mesenchymal (vimentin) markers. Similarly, loss of desmosomes (intercellular junctions) was seen in placental tissues from women with pPROM.
Monitoring of Delayed Cerebral Ischemia in Patients with Subarachnoid Hemorrhage via Near-Infrared Spectroscopy

We investigated the role of near infrared spectroscopy (NIRS) in identifying delayed cerebral ischemia (DCI) in patients with subarachnoid hemorrhage (SAH). We measured the cerebral regional oxygen saturation (rSO2) continuously for 14 days. The differences in rSO2 according to DCI were analyzed. We also compared the diagnostic accuracy of NIRS and transcranial Doppler ultrasonography (TCD) for DCI detection using the area under receiver operator characteristic (ROC) curve. Fifty-two patients treated with coil embolization were enrolled, including 18 with DCI (34.6%) and 34 without DCI (65.4%). Significant differences in rSO2 levels were observed from days 7 to 9. The rSO2 level was 60.95 (58.10–62.30) at day 7 in the DCI vs. 63.90 (62.50–67.10) in the non-DCI patients. By day 8, it was 59.50 (56.90–64.50) in the DCI vs. 63.30 (59.70–68.70) in the non-DCI cases. By day 9, it was 61.85 (59.40–65.20) in the DCI vs. 66.00 (62.70–68.30) in the non-DCI. A decline of >12.7% in SO2 rate yielded a sensitivity of 94.44% (95% CI: 72.7–99.9%) and a specificity of 70.59% (95% CI: 52.5–84.9%) for identifying DCI. Changes in NIRS tended to yield better diagnostic accuracy than TCD, but were not statistically significant. NIRS is a feasible method for real-time detection of DCI.
Predicting the spatial dominance of phytoplankton in a light limited and incompletely mixed eutrophic water column using the PROTECH model

1. A phytoplankton community model [Phytoplankton RespOnses To Environmental CHange (PROTECH)] was used to examine the effect of a wide range of varied light intensities and mixed depths upon simulated phytoplankton populations. Two different column lengths of the simulated water body were examined (the upper 5 m and the whole 14.5 m water column) for each scenario. 2. The hypotheses tested were that: (i) under low light intensity and/or deep mixing the simulated community will be dominated by a phytoplankter with a low critical light intensity; (ii) at high light intensity and shallow mixing the simulated community will be dominated by small, fast-growing phytoplankters; (iii) under all conditions, except deep mixing, the largest proportion of phytoplankton biomass will be found near the surface. 3. It was found under most conditions that, although there was a bloom in the upper column (dominated by algae such as Chlorella, Ceratium or Rhodomonas), the largest phytoplankton biomass in the water column was located 9 m below the surface and consisted of solely Asterionella. This bloom was missed by the 5-m samples. Thus, using the whole column sample lengths, hypothesis (i) was not rejected but hypotheses (ii) and (iii) were refuted. 4. The inclusion of specific movement characteristics of phytoplankton in the model allowed the possibility of the dominance of multiple spaces within the water column and should be included in any model-based investigation of this topic. Further, the results from the model suggest that a reduced depth of mixing creates greater environmental heterogeneity, allowing more species to persist.
Hypoxia PET Imaging with [18F]-HX4—A Promising Next-Generation Tracer

Hypoxia—a common feature of the majority of solid tumors—is a negative prognostic factor, as it is associated with invasion, metastasis and therapy resistance. To date, a variety of methods are available for the assessment of tumor hypoxia, including the use of positron emission tomography (PET). A plethora of hypoxia PET tracers, each with its own strengths and limitations, has been developed and successfully validated, thereby providing useful prognostic or predictive information. The current review focusses on [18F]-HX4, a promising next-generation hypoxia PET tracer. After a brief history of its development, we discuss and compare its characteristics with other hypoxia PET tracers and provide an update on its progression into the clinic. Lastly, we address the potential applications of assessing tumor hypoxia using [18F]-HX4, with a focus on improving patient-tailored therapies.
Modeling Repeat DUI Offender Probation Outcomes Using the Wisconsin Risk Need Assessment

This multiyear study of felony driving while intoxicated (DWI) probationers explores the efficacy of the Wisconsin Risk Need Assessment tool along with sociodemographic factors as measures of probation outcomes. To date, few studies have explored the relationship between risk assessment data and technical violations as well as subsequent arrests of individuals on probation. The sample for this study consists of 596 chronic DWI offenders on community supervision in one county who either had been rearrested for a new offense, violated a technical condition of their probation, or committed no violations within the first 5 years of community supervision. The findings are that older defendants and those who had more dependents were more likely to have committed a technical violation compared with the other two groups. Those rearrested for a new offense were slightly younger compared with the other two groups, less likely to be employed and younger at the age of first adjudication of guilt. This study highlights the limited overall utility of the Wisconsin tool in determining probation outcomes and that static factors may be as important as dynamic factors when developing a supervision strategy for chronic DWI offenders.