Miracle-dz/UniFAR-FTUs huggingface dataset:
Employee Job Autonomy and Control in a Restructured Extension Organization

T his descriptive cross sectional census study identified the perceptions of Extension and Outreach employees of Iowa State University in the United States about job autonomy and control after two years of a major restructuring. Employees perceived autonomy and control over expressing views and ideas about their work and spending time on the job but perceived little influence over budget allocations and shaping organizational strategies. They felt administrators and external funding sources influenced programming. They perceived contributing most to program implementation and marketing. The findings from this study have implications for operations and programming in Extension and other organizational settings. INTRODUCTION The United States economic recession that began in 2007 and the subsequent financial crisis of 2008 left many public organizations reassessing their financial foundations and value proposition. In response, these organizations employed various strategies to maintain their services (Holz-Clause et al., 2012). Organizational restructuring, one strategy adopted during difficult financial times, has become an important strategic response to budget cuts (McKinley & Scherer, 2000). This strategy has been utilized in the Cooperative Extension System (CES) within the United States, as state and federal budgets have been declining in relative terms. Many CESs have restructured their services in the past 20 years with varying degrees of success A recent example of restructuring is a CES at Iowa State University. Financial realities required a plan that addressed revenue reductions while maintaining an orderly reduction to staff and consistent delivery of programs. The goal was a more efficient administrative structure. The argument was presented that it was appropriate to move from the anachronistic geographically focused structure to an issues-based one. The result was a regional administrative model with far more local/county control and responsibility. The main components of the regional model included (1) elimination of the five area administrative positions and associated office and staffs, (2) elimination of all 100 county extension education director positions, (3) creation of 20 new Extension regions with 20 regional directors (REEDs) overseeing the operations and programming of group of counties in the region, and (4) reduction of the five main Extension programs to three by combining 4-H Youth Development with the Families program area and Community Economic Development program area with the Business & Industry program area. This restructuring resulted in layoffs while concurrently changing work jurisdictions and
450 million years in the making: mapping the evolutionary foundations of germinal centers

Germinal centers (GCs) are distinct microanatomical structures that form in the secondary lymphoid organs of endothermic vertebrates (i.e., mammals and some birds). Within GCs, B cells undergo a Darwinian selection process to identify clones which can respond to pathogen insult as well as affinity mature the B cell repertoire. The GC response ultimately generates memory B cells and bone marrow plasma cells which facilitate humoral immunological memory, the basis for successful vaccination programs. GCs have not been observed in the secondary lymphoid organs of ectothermic jawed vertebrates (i.e., fishes, reptiles, and amphibians). However, abundant research over the past decades has indicated these organisms can produce antigen specific B cell responses and some degree of affinity maturation. This review examines data demonstrating that the fundamentals of B cell selection may be more conserved across vertebrate phylogeny than previously anticipated. Further, research in both conventional mammalian model systems and comparative models raises the question of what evolutionary benefit GCs provide endotherms if they are seemingly unnecessary for generating the basic functional components of jawed vertebrate humoral adaptive immune responses.
A Marching-on-in-Time Method of Moments for Computation of Transient Potential Rise of Grounding Grids Exposed to Lightning Strikes

The article proposes an efficient full-wave electromagnetic method to compute the value of the ground potential rise for a grounding system exposed to the first and subsequent lightning strokes. The grounding system consists of a grid of several vertical and horizontal electrodes (with no constraints on the number of electrodes) buried in a lossy soil. The proposed method adopts a time-domain (TD) numerical method based on the method of moments (MoM) and marching-on-in-time to solve the governing TD electric field integral equation. This is done by expanding the unknown currents along the conductor in terms of a finite linear combination of products of appropriate spatial and temporal basis functions. Using the Galerkin method in space and the point matching method in time leads to a recursive computation of the current both in space and time. Compared to its rival frequency-domain MoM (FD-MoM) modeling, the proposed method is found to be computationally much more efficient as no matrix filling or inversion is required for a large number of frequencies. The efficiency of the proposed method is demonstrated by comparing the simulation results of several case studies with those obtained using the conventional FD-MoM modeling.
Nrl Plasma Formulary

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Single-neuron neurodegeneration as a degenerative model for Parkinson’s disease

The positive effect of levodopa in the treatment of Parkinson’s disease, although it is limited in time and has severe side effects, has encouraged the scientific community to look for new drugs that can stop the neurodegenerative process or even regenerate the neuromelanin-containing dopaminergic nigrostriatal neurons. Successful preclinical studies with coenzyme Q10, mitoquinone, isradipine, nilotinib, TCH346, neurturin, zonisamide, deferiprone, prasinezumab, and cinpanemab prompted clinical trials. However, these failed and after more than 50 years levodopa continues to be the key drug in the treatment of the disease, despite its severe side effects after 4–6 years of chronic treatment. The lack of translated successful results obtained in preclinical investigations based on the use of neurotoxins that do not exist in the human body as new drugs for Parkinson’s disease treatment is a big problem. In our opinion, the cause of these failures lies in the experimental animal models involving neurotoxins that do not exist in the human body, such as 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and 6-hydroxydopamine, that induce a very fast, massive and expansive neurodegenerative process, which contrasts with the extremely slow one of neuromelanin-containing dopaminergic neurons. The exceedingly slow progress of the neurodegenerative process of the nigrostriatal neurons in idiopathic Parkinson’s patients is due to (i) a degenerative model in which the neurotoxic effect of an endogenous neurotoxin affects a single neuron, (ii) a neurotoxic event that is not expansive and (iii) the fact that the neurotoxin that triggers the neurodegenerative process is produced inside the neuromelanin-containing dopaminergic neurons. The endogenous neurotoxin that fits this degenerative model involving one single neuron at a time is aminochrome, since it (i) is generated within neuromelanin-containing dopaminergic neurons, (ii) does not cause an expansive neurotoxic effect and (iii) triggers all the mechanisms involved in the neurodegenerative process of the nigrostriatal neurons in idiopathic Parkinson’s disease. In conclusion, based on the hypothesis that the neurodegenerative process of idiopathic Parkinson’s disease corresponds to a single-neuron neurodegeneration model, we must search for molecules that increase the expression of the neuroprotective enzymes DT-diaphorase and glutathione transferase M2-2. It has been observed that the activation of the Kelch-like ECH-associated protein 1/nuclear factor (erythroid-derived 2)-like 2 pathway is associated with the transcriptional activation of the DT-diaphorase and glutathione transferase genes.
Exploring the Underlying Mechanism of Alpinia officinarum Hance Ameliorating Diabetic Gastroparesis through Combining Network Pharmacology, Molecular Docking, and in Vivo Experimental Verification.

BACKGROUND Alpinia officinarum Hance (AOH) has a long history in China as a Chinese medicine and exerts the pharmacological effects of antidiabetic and gastrointestinal protection. In traditional Chinese medicine theory, AOH is often combined with other Chinese medicines for the treatment of diabetic gastroparesis (DGP). However, the molecular mechanisms, potential targets, and bioactive ingredients of AOH that act against DGP are yet to be elucidated. In this study, network pharmacology, molecular docking, and experimental study were used to predict the therapeutic effects and the potential molecular mechanism of AOH in DGP. METHODS Network pharmacology analysis was performed to acquire information on the active chemical ingredients, DGP-related target proteins in AOH, and potential signaling pathway. In addition, molecular docking approach was used to simulate the binding of drugs and targets. Finally, DGP-mice model was used for experimental verification in vivo. Results: Through the network pharmacological research, AKT1 was found to be the core protein in AOH for the treatment of DGP and was mainly involved in the PI3K-AKT signaling pathway. Additionally, the interactions between bioactive compounds and target proteins (PIK3CA and AKT1) were analyzed using molecular docking, which verified the results of network pharmacology. Further in vivo studies indicated that AOH could reduce fasting blood glucose levels, improve gastric emptying rate, and ameliorate biochemical indicators in DGP mice. Moreover, AOH could increase the expressions and phosphorylation levels of PI3K and AKT in the stomach to regulate oxidative stress. CONCLUSIONS The study has shown that AOH may play a protective role on DGP through mediation of the PI3K-AKT signaling pathway to regulate oxidative stress.
Acceptability and intended usage preferences for six HIV testing options among internet-using men who have sex with men

We developed an iPad-based application to administer an HIV risk assessment tool in a clinical setting. We conducted focus group discussions (FGDs) with gay, bisexual and other men who have sex with men (MSM) to assess their opinions about using such a device to share risk behavior information in a clinical setting. Participants were asked about their current assessment of their risk or any risk reduction strategies that they discussed with their healthcare providers. Participants were then asked to provide feedback about the iPad-based risk assessment, their opinions about using it in a clinic setting, and suggestions on how the assessment could be improved. FGD participants were generally receptive to the idea of using an iPad-based risk assessment during healthcare visits. Based on the results of the FGDs, an iPad-based risk assessment is a promising method for identifying those patients at highest risk for HIV transmission.
The downward transport of strong wind by convective rolls in a Mediterranean windstorm

The devastating winds in extra-tropical cyclones can be assigned to different mesoscale flows. How these strong winds are transported to the surface is discussed for the Mediterranean windstorm Adrian (Vaia), which caused extensive damage in Corsica in October 2018. A mesoscale analysis based on a kilometer-scale simulation with the Meso-NH model shows that the strongest winds come from a cold conveyor belt (CCB). The focus then shifts to a large-eddy simulation (LES) for which the strongest winds over the sea are located in a convective boundary layer. Convection is organized into coherent turbulent structures in the form of convective rolls. It is their downward branches that contribute most to the non-local transport of strong winds from the CCB to the surface layer. On landing, the convective rolls break up because of the complex topography of Corsica. Sensitivity experiments to horizontal grid spacing show similar organization of boundary layer rolls across the resolution. A comparative analysis of the kinetic energy spectra suggests that a grid spacing of 200 m is sufficient to represent the vertical transport of strong winds through convective rolls. Contrary to LES, convective rolls are not resolved in the kilometer-scale simulation and surface winds are overestimated due to excessive momentum transport. These results highlight the importance of convective rolls for the generation of surface wind gusts and the need to better represent them in boundary layer parameterizations.
Psychosocial characteristics and quality of life among sexual and gender minority patients with cancer

Abstract Background Underserved and minoritized patients with cancer often experience more psychosocial concerns and inferior quality of life (QOL) compared with majority populations. This study compared patient-reported psychosocial characteristics and QOL among self-identified sexual and gender minority patients with cancer vs cisgender-heterosexual patients with cancer treated at a National Cancer Institute–designated comprehensive cancer center in the United States. Methods Self-report data from 51 503 patients were obtained from an institutional standard-of-care electronic patient questionnaire that was completed prior to, or on the day of, the patient’s initial visit. The electronic patient questionnaire collects demographic information, including sexual orientation and gender identity, psychosocial variables, and QOL using the validated Short Form Health Survey–12. Sexual orientation and gender identity information was used to identify self-identified sexual and gender minority and cisgender-heterosexual persons (ie, non–self-identified sexual and gender minority). Using parametric analyses, psychosocial variables and QOL measures were compared for self-identified sexual and gender minority vs non–self-identified sexual and gender minority patients with cancer. Results Compared with non–self-identified sexual and gender minority patients (n = 50 116), self-identified sexual and gender minority patients (n = 1387, 2.7%) reported statistically significantly greater concerns regarding getting help during treatment (2.6% vs 4.3%, respectively; P = .001) and concerns with ability to seek care (16.7% vs 21.6%, respectively, P < .001). Self-identified sexual and gender minority patients reported statistically significantly elevated mental health concerns and daily emotional and pain interference (all P < .001), whereas there was no statistically significant difference in daily interference due to physical functioning. Conclusion These data reveal real-world disparities among self-identified sexual and gender minority patients with cancer, which can be used to develop psychosocial interventions tailored to address the unique psychosocial and QOL needs of this underserved and minoritized population and to ultimately improve cancer care.
Protective effects of Scutellariae Radix Carbonisata-derived carbon dots on blood-heat and hemorrhage rats

As the charcoal processing product of Scutellariae Radix (SR), SR Carbonisata (SRC) has been clinically used as a cooling blood and hemostatic agent for thousands of years. However, the underlying active ingredients and mechanism of SRC still remained unspecified. In this study, SRC derived carbon dots (SRC-CDs) were extracted and purified from the aqueous solution of SRC, followed by physicochemical property assessment by series of technologies. The cooling blood and hemostatic effects of SRC-CDs were further evaluated via a blood-heat and hemorrhage (BHH) rat model. Results showed that the diameters of obtained fluorescent SRC-CDs ranged from 5.0 nm to 10.0 nm and possessed functional group-rich surfaces. Additionally, the as-prepared SRC-CDs showed remarkable cooling blood and hemostasis effects in BHH model, mainly manifested by significant improvement of elevated rectal temperature, inflammatory cytokines (TNF-α, IL-6, and IL-1β) levels, as well as protein expressions of myD88 and NF-κB p65, abnormal coagulation parameters (elevated APTT and FIB), hemogram parameters (RBC, HGB, and HCT), and histopathological changes in lung and gastric tissues. This study, for the first time, demonstrated that SRC-CDs were the cooling blood and hemostatic active components of SRC, which could inhibit the release of inflammatory cytokines by regulating myD88/NF-κB signaling pathway, and activating the fibrin system and endogenous coagulation pathway. These results not only provide a new perspective for the study of active ingredients of carbonized herbs represented by SRC, but also lay an experimental foundation for the development of next-generation nanomedicines.
Testing the influence of radio programs on climate change knowledge: A pilot experience from the Congo Basin

This working paper sheds light on the impact of radio programs on the climate change knowledge of local populations in the Congo Basin. We provide an assessment of the change in knowledge of a rural village in the Congo Basin after inhabitants listened to one of the radio programs that were prepared on climate change. The document also provides potential indicators for result up-scaling. After applying a micro-economic model to a case-control experiment, both before and after exposure to one radio program, the results show an increase in knowledge of 22.3% attributable to the radio program. In addition, a series of reactions were recorded from different end users, such as other media, ministries, NGO representatives and researchers, who reacted positively to the broadcasts. We recommend the use of radio programs to increase knowledge and induce behavioral changes with regard to climate change adaptation and mitigation
Elevated Free Thyroxine Levels Might Alter the Effect of the Lipid Profile on Insulin Resistance in Type 2 Diabetes Mellitus

Previous studies have shown that hyperthyroidism is associated with heightened insulin resistance and dyslipidemia. Therefore, in this study, we aim to explore the relationship between elevated thyroid hormone levels and the lipid profile in insulin resistance in patients with type 2 diabetes mellitus (T2DM) with hyperthyroidism. A total of 177 participants were included and grouped according to diagnosis. The serum test results demonstrated that free thyroxine (FT4) increased the insulin resistance index (HOMA-IR) by positively correlating with triglyceride (TG) levels (p = 0.005, r2 = 0.35). In patients with T2DM with hyperthyroidism, the decreasing high-density lipoprotein levels showed an association with HOMA-IR (p = 0.005). Among all the patients, with different levels of FT4, the areas under the ROC curve (AUCs) of the TG level, TG/high-density lipoprotein ratio, and HOMA-IR were 0.620 (95% CI: 0.536 to 0.698), 0.614 (95% CI: 0.530 to 0.692), and 0.722 (95% CI: 0.645 to 0.791), respectively. Our results suggest that elevated FT4 levels due to hyperthyroidism could alter the association with the lipid profile and insulin resistance in patients with T2DM. We also suggest that among all the included patients with T2DM, irrespective of the presence of hyperthyroidism, FT4 levels are positively correlated with insulin resistance.
Comparison of Separation Control Mechanisms for Synthetic Jet and Plasma Actuators

This study numerically investigated the mechanisms of separation control using a synthetic jet (SJ) and plasma actuator (PA) around an NACA0015 airfoil at the chord Reynolds number of 63,000. Both SJ and PA were installed on the leading edge with the same order of input momentum (Cμ=O(10−3–10−5)) and the same actuation frequencies in F+=1.0–30. The momentum coefficient Cμ is defined as the normalized momentum introduced from the SJ or the PA, and F+ stands for the actuation frequency normalized by the chord length and uniform velocity. A number of large-eddy simulations (LES) were conducted for the SJ and the PA, and the mechanisms were clarified in terms of the exchange of chordwise momentum with Reynolds shear stress and coherent vortex structures. First, four main differences in the induced flows of the SJ and the PA were clarified as follows: (A) wall-tangential velocity; (B) three-dimensional flow structures; (C) spatial locality; and (D) temporal fluctuation. Then, a common feature of flow control by the SJ and the PA was revealed: a lift-to-drag ratio was found to be better recovered in F+=6.0–20 than in other frequencies. Although there were differences in the induced flows, the phase decomposition of the flow fields identified common mechanisms that the turbulent component of the Reynolds shear stress mainly contributes to the exchange of the chordwise (streamwise) momentum; and the turbulent vortices are convected over the airfoil surface by the coherent spanwise vortices in the frequency of F+.
Biology, Society, or Choice: How Do Non-Experts Interpret Explanations of Behaviour?

Abstract Explanations for human behaviour can be framed in many different ways, from the social-structural context to the individual motivation down to the neurobiological implementation. We know comparatively little about how people interpret these explanatory framings, and what they infer when one kind of explanation rather than another is made salient. In four experiments, UK general-population volunteers read vignettes describing the same behaviour, but providing explanations framed in different ways. In Study 1, we found that participants grouped explanations into ‘biological’, ‘psychological’ and ‘sociocultural’ clusters. Explanations with different framings were often seen as incompatible with one another, especially when one belonged to the ‘biological’ cluster and the other did not. In Study 2, we found that exposure to a particular explanatory framing triggered inferences beyond the information given. Specifically, psychological explanations led participants to assume the behaviour was malleable, and biological framings led them to assume it was not. In Studies 3A and 3B, we found that the choice of explanatory framing can affect people’s assumptions about effective interventions. For example, presenting a biological explanation increased people’s conviction that interventions like drugs would be effective, and decreased their conviction that psychological or socio-political interventions would be effective. These results illuminate the intuitive psychology of explanations, and also potential pitfalls in scientific communication. Framing an explanation in a particular way will often generate inferences in the audience—about what other factors are not causally important, how easy it is to change the behaviour, and what kinds of remedies are worth considering—that the communicator may not have anticipated and might not intend.