Miracle-dz/UniFAR-FTUs huggingface dataset:
A Systematic Literature Review of Online Repurchase Intention of Gold Jewelry

Purpose - The literature on online repurchase intention of gold jewelry is not only well organized, but also, no research focus on incorporating all previous works about it. The aim of this research will be delivering a systematic review of contributions” associated with online repurchase intention of gold jewelry”. Design/methodology/approach - This study assesses preious works covered in the Web of Science index”. Findings – Based on the aim of this study, it provides a dept literature review analysis (including different measures, methods, geographical scopes,”, etc.), and also delivers an well-organized model of Online repurchase intention. As a result of these categorizations, research gaps in the application of repurchase intention were identified. These gaps can be beneficial for researchers in the academic world as future lines of research.Implications/limitation – Providing a new approach including theoretical and practical studies by concentrating e-servicescape” as a leading factor for the online repurchase intention”. Upcoming research may assess the usefulness of various types of e-servicescape” deeply to confirm whether making a assuring structure of online repurchase intention that is conclusive and overwhelming.Implications - For private sector and governor policymakers, both cooperating chances and collaboration among the beneficiers of the Gold Jewelry ought to be reassessed by considering e-servicescape aspects.Originality/value – Including and analyzing the new aspect of e-servicescape” in the analytical review of online repurchase intention” is the Uniqueness of this research.Paper type Literature review.
Cross-Classified and Multiple Membership Models†

This paper proposes a notation and some diagrammatic tools for describing cross-classified and multiple-membership multilevel models. Example structures and analyses are given from the areas of education, psychology, medicine, and veterinary epidemiology. Keywords: multilevel models; random effects; cross-classified; nonnested; multiple membership; variance components random coefficients
Survival Analysis and Its Predictors Among Hemodialysis Patients at Saint Paul Hospital Millennium Medical College and Myungsung Christian Medical Center in Addis Ababa, Ethiopia, 2021

Background Diabetes mellitus and hypertension are the most prominent conditions causing chronic kidney disease and eventually end-stage renal disease. Renal replacement therapy, particularly hemodialysis (HD), is the mainstay of treatment. The aim of this study is to assess the overall survival status of HD patients and potential survival predictors at Saint Paul hospital millennium medical college (SPHMMC) and Myungsung Christian Medical Center (MCM) in Addis Ababa, Ethiopia. Methods A retrospective cohort study was conducted on HD patients at SPHMMC and MCM general hospital from January 1, 2013 to December 30, 2020. Kaplan Meier, Log-rank, and Cox proportional regression models were used for the analysis. Estimated risks were reported as hazard ratios with 95% confidence intervals and P<0.05 was considered as having a significant association. Results A total of 128 patients were included in the study. Median survival time was 65 months. The predominant co-morbid condition was found to be diabetes mellitus with hypertension (42%). The total risk time for these patients was 143,617 person years. The overall incidence rate of death was 2.9 per 10,000 person years (95% CI=2.2–4). Patients who developed blood stream infection were 2.98-times more likely to die than those without infection. Those using an arteriovenous fistula were 66% less likely to die than those using a central venous catheter. Additionally, patients treated in a government-owned facility were 79% less likely to die. Conclusion The study identified that the median survival time of 65 months was comparable with developed nations. Significant predictors of death were found to be blood stream infection and type of vascular access. Government-owned treatment facilities showed better patient survival.
Multidrug resistance in Helicobacter pylori infection

Helicobacter pylori (Hp), a well-known human pathogen, causes one of the most common chronic bacterial infections and plays an important role in the emergence of chronic progressive gastric inflammation and a variety of gastrointestinal diseases. The prevalence of Hp infection varies worldwide and is indirectly proportional to socio-economic status, especially during childhood. The response to the eradication therapy significantly depends on the antibiotic resistance specific to each geographical region; thus, currently, given the increasing prevalence of antimicrobial resistance (especially to clarithromycin, metronidazole, and levofloxacin), successful treatment for Hp eradication has become a real challenge and a critical issue. The most incriminated factors associated with multidrug resistance (MDR) in Hp proved to be the overuse or the improper use of antibiotics, poor medication adherence, and bacterial-related factors including efflux pumps, mutations, and biofilms. Up to 30% of first-line therapy fails due to poor patient compliance, high gastric acidity, or high bacteremia levels. Hence, it is of great importance to consider new eradication regimens such as vonoprazan-containing triple therapies, quintuple therapies, high-dose dual therapies, and standard triple therapies with probiotics, requiring further studies and thorough assessment. Strain susceptibility testing is also necessary for an optimal approach.
ON THREE-DIMENSIONAL DYNAMICAL SYSTEMS CLOSE TO SYSTEMS WITH A STRUCTURALLY UNSTABLE HOMOCLINIC CURVE. II

In this paper three-dimensional dynamical systems are considered that are close to systems with a structurally unstable homoclinic curve, i.e. with a path biasymptotic to a structurally stable periodic motion of saddle type to which the stable and unstable manifolds are tangent. Under the assumption that the tangency is the simplest structurally unstable one, it is established that in the set of paths lying entirely in an extended neighborhood of a periodic motion there is a subset whose paths are in one-to-one correspondence with the paths of a subsystem of a Bernoulli scheme of three symbols. Bibliography: 6 items.
From evil demiurge to caring hero: images of geneticists in the movies

ABSTRACT Although images of science and scientists depicted in popular culture have been criticized as an exaggeration and fear mongering, the cinema is an important resource that influences individuals’ beliefs about science. Because popular depictions of science play a crucial role in constructing the public’s ‘scientific imaginary’ they constitute an inherent dimension of the social understanding of science and are as important for science communication as the ‘real’ science. Fictional filmic representations of geneticists portrayed in 145 films reveal that popular culture (re)constructs common images and stereotypes of scientists. While the most prevalent negative stereotypes depicted in films include: the evil demiurge, the egoist without morals, the nerdy geneticist, and the capitalist who betrays the ethos of science, over the last few decades films tend to construct more positive images of geneticists: the objective researcher, the practical expert, the bioethicist, the caring physician and the dedicated idealist. Additionally, although molecular biology depicted in films largely represents a man’s world, especially since the 1990s, the figure of the woman geneticist is on the rise. The coexistence of multiple representations of geneticists in films demonstrate that cinematic images of geneticists constitute an important narrative tool that helps moviemakers in reconstructing the social promises and perils related to biotechnology. Thus, films should be understood as a site for the examination of how popular culture fuels hopes and anxieties related to the scientific revolution that permeate culture and how these hopes and fears change over time from horror to hope and from fiction to reality.
Efficacy of Varenicline in the Treatment of Alcohol Dependence: An Updated Meta-Analysis and Meta-Regression

Background: Although varenicline has been used for alcohol dependence (AD) treatment, its efficacy for this condition remains controversial. Aims: This systematic review and meta-analysis of randomized controlled trials (RCTs) assesses the efficacy and safety of varenicline in patients with AD. Methods: PubMed, Cochrane Library, ScienceDirect, Web of Science, and ThaiLis were systematically searched. RCTs investigating the efficacy and safety of varenicline in patients with AD were included. Study selection, data extraction, and quality assessment were independently performed by two authors. The Jadad score and Cochrane risk of bias were used to assess the quality of the included studies. Heterogeneity was assessed using I2 and chi-squared tests. Results: Twenty-two high-quality RCTs on 1421 participants were included. Varenicline significantly reduced alcohol-related outcomes compared with placebo based on percentage of abstinent days (standardized mean difference [SMD] 4.20 days; 95% confidence interval [CI]: 0.21, 8.19; p = 0.04), drinks per day (SMD −0.23 drinks; 95% CI: −0.43, −0.04; p = 0.02), drinks per drinking day (SMD −0.24 drinks; 95% CI: −0.44, −0.05; p = 0.01), craving assessed using the Penn alcohol craving scale (SMD −0.35; 95% CI: −0.59, −0.12; p = 0.003), and craving assessed using the alcohol urge questionnaire (SMD −1.41; 95% CI: −2.12, −0.71; p < 0.0001). However, there were no significant effects on abstinence rate, percentage of drinking days, percentage of heavy drinking days, alcohol intoxication, or drug compliance. Serious side effects were not observed in the varenicline or placebo groups. Conclusion: Our results indicated that AD patients treated with varenicline showed improvement in percentage of very heavy drinking days, percentage of abstinent days, drinks per day, drinks per drinking day, and craving. However, well-designed RCTs with a large sample size and long duration on varenicline treatment in AD remain warranted to confirm our findings.
Mobility comparison between front and back channels in ultrathin silicon-on-insulator metal-oxide-semiconductor field-effect transistors by the front-gate split capacitance-voltage method

The mobilities of the front and back channels in ultrathin silicon-on-insulator metal-oxide-semiconductor field-effect transistors with a thin (2nm) gate oxide were compared. From front-gate split capacitance-voltage measurements, it was confirmed that the effective mobility of the front channel is lower than that of the back channel. A detailed analysis shows that this lowering strongly depends on the electron density, suggesting the presence of additional Coulomb scattering centers at the front channel.
An integrated water resource management approach for Lake Trasimeno, Italy

ABSTRACT This study aims to outline governance actions to mitigate impacts of climate change scenarios (drought) in Lake Trasimeno. A water balance model was integrated with a decision support system to evaluate water levels and water management scenarios. Water quality indices, based on Sentinel-2 images, allow the monitoring of parameters such as chlorophyll-a and turbidity. The possibility of diverting water volume from Montedoglio or Casanova reservoirs into Trasimeno Lake, according to the hypothesis of different “intervention thresholds levels” and volumes immitted, is investigated. Simulation results show that hydrometric zero represents the optimal threshold, maximizing the volume supplied and mitigating a water level decrease. An inverse correlation was observed between the lake water levels, turbidity, and chlorophyll-a concentration indices. Even if further studies to test the effects of mixing water with different physical and chemical characteristics are necessary, the proposed mitigation strategy could avoid the rapid growth of the above-mentioned quality parameters.
Molecular Mechanisms of Nemorosone-Induced Ferroptosis in Cancer Cells

Ferroptosis is an iron-dependent cell death-driven by excessive peroxidation of polyunsaturated fatty acids (PUFAs) of membranes. A growing body of evidence suggests the induction of ferroptosis as a cutting-edge strategy in cancer treatment research. Despite the essential role of mitochondria in cellular metabolism, bioenergetics, and cell death, their function in ferroptosis is still poorly understood. Recently, mitochondria were elucidated as an important component in cysteine-deprivation-induced (CDI) ferroptosis, which provides novel targets in the search for new ferroptosis-inducing compounds (FINs). Here, we identified the natural mitochondrial uncoupler nemorosone as a ferroptosis inducer in cancer cells. Interestingly, nemorosone triggers ferroptosis by a double-edged mechanism. In addition to decreasing the glutathione (GSH) levels by blocking the System xc cystine/glutamate antiporter (SLC7A11), nemorosone increases the intracellular labile Fe2+ pool via heme oxygenase-1 (HMOX1) induction. Interestingly, a structural variant of nemorosone (O-methylated nemorosone), having lost the capacity to uncouple mitochondrial respiration, does not trigger cell death anymore, suggesting that the mitochondrial bioenergetic disruption via mitochondrial uncoupling is necessary for nemorosone-induced ferroptosis. Our results open novel opportunities for cancer cell killing by mitochondrial uncoupling-induced ferroptosis.
PET tracers in glioblastoma: Toward neurotheranostics as an individualized medicine approach

Over the past decade, theragnostic radiopharmaceuticals have been used in nuclear medicine for both diagnosis and treatment of various tumors. In this review, we carried out a literature search to investigate and explain the role of radiotracers in the theragnostic approach to glioblastoma multiform (GBM). We primarily focused on basic and rather common positron emotion tomography (PET) radiotracers in these tumors. Subsequently, we introduced and evaluated the preclinical and clinical results of theranostic-based biomarkers including integrin receptor family, prostate-specific membrane antigen (PSMA), fibroblast activated protein (FAP), somatostatin receptors (SRS), and chemokine receptor-4 (CXCR4) for patients with GBM to confer the benefit of personalized therapy. Moreover, promising research opportunities that could have a profound impact on the treatment of GBM over the next decade are also highlighted. Preliminary results showed the potential feasibility of the theragnostic approach using theses biomarkers in GBM patients.
Does daily physical activity reflect claudication distance measured on a treadmill and in a community outdoor setting?

INTRODUCTION AND OBJECTIVE Low physical activity in patients with claudication is associated with lower walking abilities as assessed by the treadmill test. The impact of physical activity on the ability to walk in a natural environment is unknown. The study aimed to assess the level of daily physical activity among patients with claudication, as well as the relationship between the level of daily physical activity and claudication distance measured during the outdoor walking and treadmill tests. MATERIAL AND METHODS The study included 37 patients (24 males), aged 70.03±5.9, with intermittent claudication. Daily step count was assessed using the Garmin Vivofit activity monitor, worn on the non-dominant wrist for 7 consecutive days. Pain-free walking distance (PFWDTT) and maximal walking distance (MWDTT) were measured via the treadmill test. During 60-minute outdoor walking, the maximal walking distance (MWDGPS), total walking distance (TWDGPS), walking speed (WSGPS), number of stops (NSGPS) and stop durations (SDGPS) were assessed. RESULTS Mean daily step count - 7,102±3,433. A significant correlation was observed between daily step count and MWDTT, TWDGPS (R=0.33, R=0.37, respectively (p<0.05). Furthermore, 51% of patients reached less than 7,500 steps/day and presented significantly shorter MWDTT, MWDGPS and TWDGPS, compared to the participants covering ≥7,500 steps (p<0.05). CONCLUSIONS The daily step count reflects claudication distance measured on a treadmill and only partially in a community outdoor setting. The minimal daily step count that should be recommended for patients with claudication, allowing achievement of significantly better results with regard to walking abilities, both on the treadmill and in outdoor settings, is at least 7,500 steps per day.
Reconstruction of a Comprehensive Interactome and Experimental Data Analysis of FRA10AC1 May Provide Insights into Its Biological Role in Health and Disease

FRA10AC1, the causative gene for the manifestation of the FRA10A fragile site, encodes a well-conserved nuclear protein characterized as a non-core spliceosomal component. Pre-mRNA splicing perturbations have been linked with neurodevelopmental diseases. FRA10AC1 variants have been, recently, causally linked with severe neuropathological and growth retardation phenotypes. To further elucidate the participation of FRA10AC1 in spliceosomal multiprotein complexes and its involvement in neurological phenotypes related to splicing, we exploited protein–protein interaction experimental data and explored network information and information deduced from transcriptomics. We confirmed the direct interaction of FRA10AC1with ESS2, a non-core spliceosomal protein, mapped their interacting domains, and documented their tissue co-localization and physical interaction at the level of intracellular protein stoichiometries. Although FRA10AC1 and SF3B2, a major core spliceosomal protein, were shown to interact under in vitro conditions, the endogenous proteins failed to co-immunoprecipitate. A reconstruction of a comprehensive, strictly binary, protein–protein interaction network of FRA10AC1 revealed dense interconnectivity with many disease-associated spliceosomal components and several non-spliceosomal regulatory proteins. The topological neighborhood of FRA10AC1 depicts an interactome associated with multiple severe monogenic and multifactorial neurodevelopmental diseases mainly referring to spliceosomopathies. Our results suggest that FRA10AC1 involvement in pre-mRNA processing might be strengthened by interconnecting splicing with transcription and mRNA export, and they propose the broader role(s) of FRA10AC1 in cell pathophysiology.
The Effect of Human and Bovine Milk Osteopontin on Intestinal Caco-2 Cells: A Transcriptome Comparison

Osteopontin (OPN) is a multifunctional protein abundantly present in human milk, whereas the concentration is significantly lower in bovine milk. Human and bovine milk OPN are structurally similar and both proteins resist gastric digestion and reach the intestines in a bioactive form. Intervention studies have indicated the beneficial effects of supplementing infant formula with bovine milk OPN and several in vivo and in vitro studies have shown that bovine milk OPN positively influences intestinal development. To investigate the functional relationship, we compared the effect of simulated gastrointestinal digested human and bovine milk OPN on gene expression in Caco-2 cells. After incubation, total RNA was extracted and sequenced and transcripts were mapped to the human genome. Human and bovine milk OPN regulated the expression of 239 and 322 genes, respectively. A total of 131 genes were similarly regulated by the OPNs. As a control, a whey protein fraction with a high content of alpha-lactalbumin had a very limited transcriptional impact on the cells. Enrichment data analysis showed that biological processes related to the ubiquitin system, DNA binding, and genes associated with transcription and transcription control pathways were affected by the OPNs. Collectively, this study shows that human and bovine milk OPN have a significant and highly comparable effect on the intestinal transcriptome.
Prediction of The Mechanical Behavior of Polylactic Acid Parts with Shape Memory Effect Fabricated by FDM

In this study, the mechanical as well as thermomechanical behaviors of shape memory PLA parts are presented. A total of 120 sets with five variable printing parameters were printed by the FDM method. The impact of the printing parameters on the tensile strength, viscoelastic performance, shape fixity, and recovery coefficients were studied. The results show that two printing parameters, the temperature of the extruder and the nozzle diameter, were more significant for the mechanical properties. The values of tensile strength varied from 32 MPa to 50 MPa. The use of a suitable Mooney–Rivlin model to describe the hyperelastic behavior of the material allowed us to gain a good fit for the experimental and simulation curves. For the first time, using this material and method of 3D printing, the thermomechanical analysis (TMA) allowed us to evaluate the thermal deformation of the sample and obtain values of the coefficient of thermal expansion (CTE) at different temperatures, directions, and running curves from 71.37 ppm/K to 276.53 ppm/K. Dynamic mechanical analysis (DMA) showed a similar characteristic of curves and similar values with a deviation of 1–2% despite different printing parameters. The glass transition temperature for all samples with different measurement curves ranged from 63–69 °C. A material crystallinity of 2.2%, considered by differential scanning calorimetry (DSC), confirmed its amorphous nature. From the SMP cycle test, we observed that the stronger the sample, the lower the fatigue from cycle to cycle observed when restoring the initial shape after deformation, while the fixation of the shape did not almost decrease with each SMP cycle and was close to 100%. Comprehensive study demonstrated a complex operational relationship between determined mechanical and thermomechanical properties, combining the characteristics of a thermoplastic material with the shape memory effect and FDM printing parameters.
Effect of polymorphisms in drug metabolism and transportation on plasma concentration of atorvastatin and its metabolites in patients with chronic kidney disease

Dyslipidemia due to renal insufficiency is a common complication in patients with chronic kidney diseases (CKD), and a major risk factor for the development of cardiovascular events. Atorvastatin (AT) is mainly used in the treatment of dyslipidemia in patients with CKD. However, response to the atorvastatin varies inter-individually in clinical applications. We examined the association between polymorphisms in genes involved in drug metabolism and transport, and plasma concentrations of atorvastatin and its metabolites (2-hydroxy atorvastatin (2-AT), 2-hydroxy atorvastatin lactone (2-ATL), 4-hydroxy atorvastatin (4-AT), 4-hydroxy atorvastatin lactone (4-ATL), atorvastatin lactone (ATL)) in kidney diseases patients. Genotypes were determined using TaqMan real time PCR in 212 CKD patients, treated with 20 mg of atorvastatin daily for 6 weeks. The steady state plasma concentrations of atorvastatin and its metabolites were quantified using ultraperformance liquid chromatography in combination with triple quadrupole mass spectrometry (UPLC−MS/MS). Univariate and multivariate analyses showed the variant in ABCC4 (rs3742106) was associated with decreased concentrations of AT and its metabolites (2-AT+2-ATL: β = -0.162, p = 0.028 in the dominant model; AT+2-AT+4-AT: β = -0.212, p = 0.028 in the genotype model), while patients carrying the variant allele ABCC4-rs868853 (β = 0.177, p = 0.011) or NR1I2-rs6785049 (β = 0.123, p = 0.044) had higher concentrations of 2-AT+2-ATL in plasma compared with homozygous wildtype carriers. Luciferase activity was enhanced in HepG2 cells harboring a construct expressing the rs3742106-T allele or the rs868853-G allele (p < 0.05 for each) compared with a construct expressing the rs3742106G or the rs868853-A allele. These findings suggest that two functional polymorphisms in the ABCC4 gene may affect transcriptional activity, thereby directly or indirectly affecting release of AT and its metabolites from hepatocytes into the circulation.