Miracle-dz/UniFAR-FTUs huggingface dataset:
RISULTATI A DISTANZA E PIANIFICAZIONE TERAPEUTICA DEI TUMORI SEMINALI DEL TESTICOLO

The paper retrospectively reviews the modalities and the long-term results of treatment of 200 consecutive patients with pure seminoma and of 125 patients with testicular carcinomas admitted to the Istituto Nazionale per 10 Studio e la Cura dei Tumori of Milan from 1929 to Jan 1973. Radical orchiectomy with high ligation of the spermatic cord at the internal inguinal ring was performed in all previously untreated patients. Those who had had a scrotal operation performed elsewhere were radically reoperated upon. Lymphography and cobalt 60 telecurietherapy were introduced in 1960 and new treatment plans were employed for the irradiation of the deep Iymphnodes. Since 1968 all operable carcinomas have undergone bilateral retroperitoneal lymphadenectomy and since 1964 all patients with advanced disease have been treated with chemotherapy (single agent or combination). Survival rates were calculated by the actuarial method. The new treatment modalities proved to be significantly superior to the old ones. In pure seminoma a 92 % cure rate was obtained in NO patients after prophylactic irradiation of retroperitoneal nodes (2,500-3,000 rad in 3 weeks). In NI-3 patients the cure rate was as high as 75 % after radical irradiation of retroperitoneal nodes (3,500-4,000 rad in 4 weeks) as well as prophylactic irradiation of mediastinum and both supraclavicular fossae. Extended radical radiotherapy (combined with chemotherapy in some patients) cured 2/6 N4 and 3/8 Ml patients. According to the old modalities of treatment, figures were respectively 72 % in NO cases, 40 % in NI-3 and 0 % in N4 and Ml patients. In carcinomas, the cure rate after retroperitoneal lymphadenectomy was 91 % in Npatients and 47 % in N+ cases. In N+ patients post-operative radiation was also performed (4,000-5,000 rad in 5 weeks). After radiotherapy alone (without lymphadenectomy) the rates were 62 % in NO and 28 % in NI-2 patients. In primary inoperable patients (N3-4 and Ml) chemotherapy, with or without radiation ,significantly prolonged the survival rate. It is concluded that radiotherapy is the treatment of choice for pure seminoma and in N4 and Ml cases a full course of chemotherapy must be combined with extensive irradiation. Retroperitoneal lymphadenectomy is mandatory in all operable cases of testicular carcinoma while adjuvant chemotherapy may further improve the prognosis in N + cases. For inoperable carcinomas chemotherapy (plus radiotherapy) is the treatment of choice. The new multiple drug regimens are providing encouraging results.
Double-dissociation of frequency-specific contributions of dorso-lateral and dorso-medial prefrontal cortex to familiarity and recollective processes in the primate

According to dual-process theories, recognition memory draws upon both familiarity and recollection. It remains unclear how primate prefrontal cortex (PFC) contributes to familiarity and recollection processes but frequency-specific neuronal oscillations are considered to play a key role. Here, non-human primate (NHP) electrophysiological recordings first showed that a specific subregion of macaque PFC (i.e., dorsolateral PFC, dlPFC) was implicated at a specific frequency (i.e., increased beta oscillatory power) in a specific phase of a recognition memory task (i.e., during sample presentation). Then, to assess generalization to humans we targeted left human dlPFC (BA 9/46) as well as left dorsomedial prefrontal cortex (BA 8/9) for comparison, and also vertex as a control, with low-beta frequency transcranial magnetic stimulation (compared to non-frequency-specific stimulation, and to no-stimulation control) during occasional sample presentations within a similar task; hence we investigated the causal importance for human memory of a location-specific, frequency-specific, and task-epoch-specific intervention derived directly from the NHP electrophysiological observations. Using a dual-process signal detection (DPSD) model based on analysing receiver operating characteristics (ROC) curves, we showed beta-frequency TMS caused decreased recollection when targeted to human dlPFC, but enhanced familiarity when targeted to dorsomedial prefrontal cortex. Non-frequency-specific patterns of stimulation to all sites, and beta-frequency stimulation to vertex, were all without behavioural effect. This study provides causal evidence that PFC-mediated contributions to object recognition memory are modulated by beta-frequency oscillations; more broadly it provides translational evidence bridging NHPs and humans by emphasizing functional roles of beta oscillations in homologous brain regions in recognition memory. Significance Statement Recognition memory is assumed to draw upon both familiarity and recollection. Little is known yet about how neural oscillations in different sub-regions of primate prefrontal cortex (PFC) underlies these two processes. By recording macaque local field potentials we first observed modulation of beta-frequency oscillatory power in dorsolateral PFC during sample stimulus encoding. Then, in an analogous recognition memory task in humans, we used targeted transcranial magnetic stimulation (TMS) to causally influence PFC mnemonic function during encoding. We revealed a double dissociation between the effects of beta-frequency stimulation to dorsolateral PFC in suppressing recollection process and dorsomedial PFC in enhancing familiarity process. These cross-species translational studies demonstrate a causal role of beta-frequency oscillations in PFC to primate recognition memory performance.
Foreign Demand and Local House Prices: Evidence from the US

We test whether foreign demand matters for local house prices in the US using an identification strategy based on the existence of “home bias abroad” in international real estate markets. Following an extreme political crisis event abroad, a proxy for a strong and exogenous shift in foreign demand, we show that house prices rise disproportionately more in neighbourhoods with a high concentration of population originating from the crisis country. This effect is strong, persistent, and robust to the exclusion of major cities. We also show that areas that were already expensive in the late 1990s have experienced the strongest foreign demand shocks and the biggest drop in affordability between 2000 and 2017. Our findings suggest a non-trivial causal effect of foreign demand shocks on local house prices over the last 20 years, especially in neighbourhoods that were already rather unaffordable for the median household.
Accuracy of Composite Attachment Position with Four Different Indirect Bonding Techniques

Introduction: Our objective was to evaluate the attachment transfer accuracy of four indirect bonding technique variations based on tray sectioning. Materials and Methods: Twenty 3D printed dental models without attachments were bonded with composite resin attachments using 0.5mm thermoform plastic template trays fabricated from physical reference models. Four IDB technique variations were studied, n=5 for each technique: 1) whole arch (Whole), 2) whole arch, buccal segment only (Halves), 3) sextants (Thirds), and 4) sextants, buccal segment only (Sixths). Dimensional deviation of attachment position was evaluated in the buccal-lingual (B/L), mesial-distal (M/D), incisal-gingival (I/G) dimensions, and in tip through model digitization and 3D software superimpositions with the reference digital model. Clinical significance cutoffs were set at 0.25mm for linear measurements and 1° for angular measurements. ANOVA and multiple comparisons were performed. Statistical significance was set at 0.05. Results: Across all techniques, a total of 142 attachments were evaluated. B/L- Left side attachments had more mean discrepancy than right side attachments, and there was a lingual bias of all attachments. M/D- The Thirds group had less deviation than all other techniques (p < 0.05). Across all attachments, there was virtually zero bias towards the mesial or distal. I/G- The Wholes and Sixths groups had the least and greatest deviation, respectively, and the difference was significant (p < 0.05). There was an incisal bias across all attachments. Tip- There was approximately a 1° distal root tip bias across all attachments. Overall, no mean linear deviations reached the clinical significance threshold, but mean angular deviations did. Conclusions: In general, all IDB techniques studied achieved clinically acceptable and similar attachment positions in the B/L, M/D, I/G, dimensions, and marginally acceptable tip angulation.
Assessment of Variations in the Physico-Mechanical Properties of Fiberglass Tubing Working in Different Environments

This paper presents the results of the experimental investigations carried out by the authors in order to evaluate the changes in the physico-mechanical properties of fiberglass tubing used to transport fluids between different facilities. In the near future, water injection wells will be equipped with fiberglass tubing, as an alternative to the more traditional metal tubing. The mechanical properties of fiberglass material (ultimate tensile strength, impact energy, burst pressure) have been determined for sets of 5 specimens that have been maintained (at a temperature of 80°C) in different environments and with different exposure times (hydrochloric acid: 6/24/48 hours; acetic acid: 6/24/48 hours; hydrochloric acid + hydrofluoric acid: 6/24/48 hours; xylene: 1/2/3 months; condensates: 1/2/3 months).
The Impacts of ERP Integration on Information Quality

The paper aims at analyzing the relationship between the level of integration of the ERP system and the information quality perceived by managers due to direct and indirect factors. In the latter model, the information quality is affected by the presence of specific features of information flow, defined as the information processing capacity, the frequency of meeting, and the information sharing. To test the research model, a PLS-SEM analysis was applied to a survey conducted in the Italian setting. Empirical results show that the level of integration of the ERP system positively affects the latent variable (features of information flow) and that the features of information flow positively affect the perceived quality of information. Empirical results also suggest that the level of integration of ERP systems can positively and indirectly affect the information quality seen by managers, by the effect of the features of information flow. Managers can benefit from this study for supporting their decision to achieve an optimal level of integration of their ERP systems to enhance the information quality within the firm.
Efficacy of transversus abdominis plane (tap) block for intraoperative and postoperative analgesia in patients undergoing abdominal hysterectomy under general anaesthesia- a randomised controlled study

Background: To evaluate the effect of transversus abdominis block for intra and post-operative analgesia in patients undergoing abdominal hysterectomy under general anaesthesia.Methods: Prospective, double-blind, randomized, clinical study on 80 patients of age 40-60 years undergoing total abdominal hysterectomy under general anaesthesia. Patients were randomly divided into 2 equal groups; Group N (n=40): TAP block with 30 ml of normal saline; Group B (n= 40): TAP block with 30 ml of 0.25% bupivacaine. All patients were given general anaesthesia followed by transversus abdominis plane block (TAP). All parameters like postoperative VAS Score, intraoperative haemodynamic changes (HR, SBP, DBP, MAP) were recorded. In the postoperative period diclofenac 1.5 mg/kg was given. If VAS ≥ 4 inj tramadol 2mg/kg i.v. was given as rescue analgesia. Total dose of diclofenac and tramadol in 24 hr post operative period was recorded.Result: The time for first analgesic request was increased in Group B 134.67±16.23 min as compared to Group N 42.85±18.13 min (P value <0.05). Maximum VAS score up to 24 hrs postoperative was lower in the Group B (2.77 ± 9.73) as compared to group N (5.6±1.42) (P value <0.05). The rescue analgesic consumption within 24 hours post operatively was lower in Group B (105.75±71.24 mg) compared to Group N (218±40.01 mg) (P value <0.05). Conclusion: TAP block provide significant postoperative analgesia in first 24 hour and excellent hemodynamic stability being a safe modality for intra and post operative analgesia for total abdominal hysterectomy.
MRI and MR Spectroscopy Features of Heat Stroke: A Case Report

Heat stroke is the outcome of over heat stress that results in multiorgan dysfunction with a tendency for central nervous system damage. Brain is very sensitive to hyperthermia, especially the cerebellum that has selective vulnerability to heat stroke. There is complex interaction between heat cytotoxicity, coagulation disorder, cytotoxine - mediated systemic inﬂammatory response causing multiorgan failure, metabolic derangement, and circulatory insuﬃciency. We reviewed the literature and discussed brain MRI andMRspectroscopyﬁndingsof heatstroke,detailedthepathophysiologyunderlyingbraininvolvementandproposedexcitotoxic injury as an alternative mechanism of brain damage in heat stroke. pathways and tegmental tracts of the in the external capsules, thalami, hippothalami, and hippocampi with acute pansinusitis and bilataral granulomatous otitis.
A study to assess knowledge and perception on obesity among female aged eighteen years and above living in ladies dorm at UEAB, Kenya

Background: Obesity is an ongoing problem in the developed countries and it’s a new and growing problem in the developing countries. This study aimed to assess the knowledge and perception on obesity among female aged 18 years. Methods: The study is a descriptive cross-sectional research design on 186 students of UEAB in 2017. In order to collect the data was used a self-administered questionnaire, which will be used to measure the knowledge level and perception to gather factual information about the respondents. This questionnaire will involve a set of closed-ended questions. The data were analysed using SPSS 23. The researchers used descriptive statistics including mean, median and mode. Results: The knowledge on obesity, it was found that most of the participants have heard of obesity and they term it as the excessive fat accumulation to body. Participants also indicated that they knew the causes of obesity and in degrees of whether they agree or disagree, indicated that they strongly agreed and agreed that consumption of junk foods and lack of physical exercise caused obesity and they agreed that family history may also cause obesity. The perception on obesity, participants viewed obesity to be average among undergraduate ladies residing in ladies’ dorm. It was also revealed that 7.5 percent of the participants think they are obese and they are unsatisfied with their body weights. Conclusions: The study exposes the lack of knowledge regarding obesity. However, perceptions of the participants were promising. This is because nearly all of them felt those who are not obese should be encouraged to maintain their weight and the overweight people should lose weight or be treated to achieve medical benefit.
Effect of Technological Innovations on Performance of Real Estate Firms in Kenya: The Case of Real Estate in Nairobi County

iv ACKNOWLEDGEMENT . vi DEDICATION. vii TABLE OF CONTENTS . viii LIST OF TABLES . x LIST OF FIGURES . xi ABBREVIATIONS AND ACRONYMS . xii CHAPTER ONE . 1 1.0 INTRODUCTION. 1 1.1 Background of the Study . 1 1.2 Statement of the Problem . 5 1.3 General Objective of the Study . 7 1.4 Objectives of the Study . 7 1.5 Significance of the Study . 7 1.6 Scope of the Study . 8 1.7 Definition of Terms. 8 1.8 Chapter Summary . 9 CHAPTER TWO . 10 2.0 LITERATURE REVIEW . 10 2.
Sports Teams as Contexts of Cultural Change: The Roles of Culture and Social Identity in Social Dominance Orientations

Intergroup conflict and inequality are ubiquitous, but a promising pathway for change is at the individual level of social dominance orientations. Culture is one antecedent of social dominance orientations, thus a change at the cultural level could influence a change in social attitudes toward inequality. Ethnographic research has identified sports teams and their identification as a context for cultural change in athletes. The current studies sought to examine sports teams as cultural contexts that are conducive for influencing intergroup attitudes. Three cross-sectional surveys were conducted of athletes from different season times, sport types and competitive levels. Study 1 (N = 169) included elite team sport athletes before, during and after competitive season. Study 2 (N = 250) expanded to elite, lower elite and intramural level athletes in team and individual sports. The final Study 3 (N = 50) assessed offseason team sport athletes across competitive levels. Overall, athletes across all conditions demonstrated higher collectivism, verticality, and lower horizontality in sports contexts regardless of their team identification. Significant mediation of verticality and indirect effects of individualism and horizontality suggest that cultural values in local contexts can potentially influence the cultural antecedents of social dominance orientations, which could then impact intergroup relations.
The workforce ageing challenge and employer response: a study of the Australian transport and logistics industry

ABSTRACT Workforce ageing is a challenging phenomenon for many countries. Its impact, however, varies widely across economies, sectors, industries and occupations. This paper examines the ways in which employer attitudes and practices help sustain the workforce ageing problem at sector and industry levels. The underpinning study was developed in the context of the Australian Transport and Logistic (T&L) sector and involved Australian Bureau of Statistics (ABS) household census data analysis and key employer interviews. The analysis concludes that, while the T&L sector experienced higher levels of workforce ageing, relative to the broader Australian economy, employers exhibited surprising complacence and a dismissive attitude towards the potential implications. Although this observation was general, there were certain clear patterns influenced by firm size, type of industry and nature of work. For example, whereas larger firms tend to be more proactive in their workforce planning generally and workforce replenishment more specifically, smaller ones, which comprised the majority tended to externalise the problem or take a ‘wait and see’ approach. As one of very few studies that closely and specifically examines the workforce ageing phenomenon from the perspective of employer behaviour, it makes significant contribution to our understanding of how employer behaviour influences industry workforce ageing.
Pengaruh Perawatan Metode Kanguru Terhadap Respon Fisiologis Bayi Berat lahir Rendah

Introduction: Low Birth Weight Babies (LBWB) is one of the causes of the high Neonatal Mortality Rate in Indonesia. This occurs because LBWB has non-optimal temperature regulation centers, thin-brown and subcutaneous fat tissue, inadequate muscle growth, and organ immaturity. Kangaroo Care (KC) is expected to be an effective and efficient solution to keep LBW in a stable condition. This study aimed to determine the effect of KC on the physiological responses of LBWB.Methods: This study is a pre-experimental design with one group pretest-posttest research design. The sample was obtained with a total sampling technique and the size was 21 LBWB. The independent variable in this study was KC; carried out for 3 days with a frequency of 2 times a day and 90 minutes per KC. Meanwhile, the dependent variable was the physiological responses of LBWB which consisted of temperature, heart rate, and oxygen saturation. The instrument used was KC observation sheets with Wilcoxon signed rank test for the data analysis.Results: The study showed that the temperature increased from 36.50C to 36.90C; the heart rate increased from 135 x/minute to 147 x/minute; the oxygen saturation increased from 93% to 98%. The results of the Wilcoxon signed rank test on the pretest-posttest data revealed that the temperature p = 0.002, heart rate frequency p = 0.001, and oxygen saturation p = 0.000. The increased physiological responses were still in the range of normal.Conclusion: The KC can maintain the stability of LBWB physiological responses. By that, it is recommended for parents to continue KC as a home-care for LBWB until the weight reached 2500 grams.
Complexity and Public Policy: Network Model of Food Security Policy Implementation in Bone Regency

Complexity and public policy are two things that cannot be separated. Determination and implementation of public policies is a complex process of interaction of all stakeholders loaded with interests, power, information, skills, and other resources. This shows the complexity in public policy that is not possible to be handled by the government alone but needs to involve all other stakeholders. So that to improve policy performance it is necessary to develop a network of all stakeholders in the implementation of public policy. This study aims to develop a network model in implementing food security policy in Bone Regency. This research was carried out in Bone Regency using a qualitative approach. Data sources used are primary data and secondary data. Data collection is done through interviews and observations. The results of this study indicate that the implementation of food security policy has not been effective. This is due to the lack of integrated food programs by all stakeholders. In this case, government agencies each design a food security program individually. Then, the Food Security Council as a network-based organization has not carried out its function in coordinating and synergizing stakeholders to design food programs that can prosper the people. As a result, poverty and food insecurity are still high in Bone Regency.
Metabolic Syndrome and Cancer: Is there a Connection?

Metabolic syndrome (MetS) has now been universally recognized as the leading cause of various life threatening chronic diseases. While diabetes and cardiovascular, with their increasing incidences globally, get the most of the research and health awareness campaign funding, there has also been a rapid increase in various types of cancer cases, especially in developing countries. What is worrying is the significantly poor outcome in terms of ‘life expectancy: treatment cost’ ratio in cancer patients when compared to diabetes and cardiovascular conditions. This entails an equally sincere focus on strategies that could either reduce cancer incidences or complement cancer pharmacotherapy to improve treatment outcome measured in terms of survival rate and quality of life.