Miracle-dz/UniFAR-FTUs huggingface dataset:
Evaluation of Dento-craniofacial Characteristics in Monozygotic Twins - Case Study

Introduction: Monozygotic twins are a valuable sample for the study of human craniofacial growth and development. Aims: The aim of the present study was to analyze the dento-craniofacial characteristics in monozygotic twins and to discuss the genetic, epigenetic and environmental influences in the twin’s phenotypic features. Material and Methods: Two 21-year-old female twins attended the Dental Service of Universidade Federal dos Vales do Jequitinhonha e Mucuri were analyzed. For validation of this study, a genetic test of zygosity was performed to confirm the individuals' monozygosity. Intraoral buccal examination revealed occlusal differences as well as disagreement in the eruption of the third molars. Results: The analysis of models showed differences in the mesio-distal diameter of the teeth of both arches, as well as disagreement in the perimeter of the mandibular arches between the two Original Research Article Rocha-Gomes et al.; JAMMR, 32(22): 10-19, 2020; Article no.JAMMR. 62473 11 individuals. The cephalometric analysis showed remarkable differences in the vertical and horizontal parameters of the craniofacial structure. The SNA, SNB and LAFH showed differences of 10o, 9o and 3mm respectively. Additionally, the components related to the dentition also showed discrepant results. Conclusion: It can be suggested that the dento-craniofacial characteristics present a genetic component; however, the interaction of epigenetic and environmental factors can lead to different phenotypes in univiteline twins.
The Relationship between Strategy of Work-life Quality and sustainable competitive advantage: A survey study on in Yemeni manufacturing industries.

The current strategies of increasing work-life quality are being given special attention by both public and private organizations. These quality strategies have arisen because of the highly competitive environment. Also, a safe and healthy work environment that provides the opportunities for employees to enhance their loyalty, affiliation and love towards their work and organization is required in order to achieve the current and future aspirations of the organization. Accordingly, this study aims to explore the direct relationship between the variables: the strategy of work-life quality, strategic agility and sustainable competitive advantage, to identify their indirect relationships with their own dimensions. In order to achieve this, a questionnaire was distributed to both heads of companies and their deputies in large and medium Yemeni manufacturing companies, using a random sampling technique to reach 227 companies out of 554 by distributing 454 questionnaires for the selected population. Cronbach’s Alpha coefficient and exploratory statistics were carried out to identify the quality of measurements used to examine the proposed theoretical method using SEM. The results of the study are that there is a direct relationship between the variables. Additionally, there is an indirect relationship between the independent variable (strategy of work-life quality) and the dependent variable (sustainable competitive advantage) using strategic agility as a mediator in Yemeni large and medium manufacturing companies. These findings ensure the validity of the proposed theoretical model. In addition, it fills the knowledge gap regarding this issue and the findings highlight the competitive challenges that Yemeni companies must be aware of.
Extent and Associated Factors of Obesity among Patients at a Specialized Outpatient Clinic in Uganda

Background: Diabetes and obesity are considered a global epidemic by the World Health Organization (WHO) due to their increasing prevalence. Obesity is common in Type 2 Diabetes (T2D) as a comorbid condition often termed as "Diabesity". Approximately 60-90% patients with T2D are overweight or obese. WHO projects 300 million people will suffer from diabetes by 2025, most of which can be attributed to obesity. There is limited data about diabesity at the study area. Therefore, our study aimed at studying the prevalence and factors associated with obesity in the study area. Methods: A facility based cross-sectional study was undertaken between August and November 2018 involving adults aged ≥ 18 years at the Diabetes outpatient clinic of Mulago National Referral Hospital. Data were collected about the participants’ sociodemographic and other characteristics by individual face to face interviews by trained study staff using a predesigned questionnaire. Body Mass Index (BMI) was calculated and classified into 3 groups: 18.5-24.9, 25.0-29.9, ≥ 30.0 as normal weight, overweight respectively following the WHO standard. Results: A total of 319 patients participated in this study: 66.46% of them were female, the mean age and age range in years was 51.1 and 20 to 77 years respectively. Obesity was prevalent in 24.45% and 15.67% had central obesity; by BMI classification 41.69%, 33.86% and 24.45% were normal weight, overweight, and obese respectively. In the multivariate regression, gender (p=0.004), age (p<0.001), DBP (p=0.003), SBP(p=0.023), family history of DM (p=0.004) and HT p=0.006), known hypertension status (p<0.001) were the risk factors significantly associated with obesity. Conclusion: Obesity is prevalent in this study population. Among the factors associated with obesity in our study, blood pressure is the only modifiable factor. Cardio-metabolic complications in patients with obesity, diabetes and hypertension are preventable through the reduction of blood pressure.
Use of liquid biopsy in monitoring therapeutic resistance in EGFR oncogene addicted NSCLC

Liquid biopsy has emerged as a minimally invasive alternative to tumor tissue analysis for the management of lung cancer patients, especially for epidermal growth factor receptor (EGFR) oncogene addicted tumor. In these patients, despite the clear benefits of tyrosine kinase inhibitors therapy, the development of acquired resistance and progressive disease is inevitable in most cases and liquid biopsy is important for molecular characterization at resistance and, being non-invasive, may be useful for disease monitoring. In this review, the authors will focus on the applications of liquid biopsy in EGFR-mutated non small cells lung cancer at diagnosis, during treatment and at progression, describing available data and possible future scenarios.
Pollen morphology of Proteaceae native to Argentina: a new dichotomus key for their identification

A dichotomous key for the identification of eight proteaceous species, native to Argentina, based on pollen morphology is presented. These species are: Embothrium coccineum, Gevuina avellana, Lomatia dentata, L. ferruginea, L. hirsuta, Orites myrtoidea, Roupala meisneri and R. montana. The pollen morphology was analyzed with both, light and electron scanning microscopes. The morphological characters selected for species/ genera recognition are: ornamentation, pore number, equatorial diameter, the ratio of sexine/nexine thickness, and equatorial diameter/pore diameter ratio.
Investigation for some Aminoglycosides Modifying Enzymes- Encoding Genes and Co-Resistance to Fluoroquinolones among Klebsiella pneumoniae Isolates from Different Clinical Cases

In this study, we investigated the prevalence of aminoglycosides modifying enzymes (AMEs)-encoding genes, including aac(3′)-ΙΙ, ant(3′′)-Ι, aph(3′)-VΙ, and aac(6′)-Ιb-cr and their potential effect on the development of resistance to aminoglycosides and fluoroquinolones in clinical isolates of Klebsiella pneumoniae. According to the phenotypic and biochemical characteristics of 150 clinical samples, 50 (33%) isolates were identified as K. pneumoniae. These isolates were collected from different clinical sources, including urine (15, 30%), blood (12, 24%), sputum (9, 18%), wounds (9, 18%), and burns (5, 10%). The minimum inhibitory concentrations (MICs) assay revealed that the resistance values of isolates were 25 (50%) to gentamicin (≥16μg/ml), 21 (42%) to amikacin (≥64 μg/ml), 15 (30%) to ciprofloxacin (≥4 μg/ml), and 11 (22%) to levofloxacin (≥8 μg/ml). Genotypic detection revealed that aac(3′)-ΙΙ, aac(6′)-Ιb-cr, aph(3′)-VΙ, and ant(3′′)-Ι were found in 47 (94%), 38 (76%), 18 (36%), and 8 (16%) of K. pneumoniae isolates, respectively. The co-resistance pattern for both aminoglycosides and fluoroquinolones was detected in 14 (28%) isolates, of these 10 (71.4%) harbored aac(6′)-Ιb-cr. DNA sequencing for some isolates revealed the presence of point and frameshift mutations in the studied genes. Our study findings suggest that the presence of missense and frameshift mutations may contribute to the elevated resistance to amikacin and gentamicin. The increased prevalence of AMEs-encoding genes among K. pneumoniae isolates could contribute in reducing susceptibility to amikacin and gentamicin. The co-resistance pattern for aminoglycosides and fluoroquinolones was highly associated with the presence of the aac(6′)-Ιb-cr gene.
Is it an advantage or disadvantage to usage angiotensin-converting enzyme inhibitor or angiotensin receptor blocker in COVID-19 patients?

Background: The use of angiotensin converting enzyme inhibitors (ACEIs) and angiotensin II receptor blockers (ARBs) is an important problem for clinicians who treat coronavirus disease (COVID-19) in patients with hypertension. The aim of the study was to reduce the confusion in this matter to some extent. Methods: This study was carried out in the Health Sciences University, Bursa High Specialization Training and Research Hospital between 23 March to 23 June 2020. Patients were evaluated using thorax computed tomography (CT) taken during hospitalization with severity and risk scoring, confusion, uraemia, respiratory rate, blood pressure, age ≥65 years, score >2 (CURB-65) for pneumonia. Results: The rate of severe pneumonia was significantly higher in the group using ACEI and ARBs. CURB 65 high risk observation rate was significantly higher in the group with ACEI and ARB using. The rate of severe pneumonia observed was significantly higher in the any antihypertensive drugs using group. This risk height is more pronounced in those using ACEI and ARBs. The mortality rate of our 500 patients with COVID-19 was 2.2% (11/500). There was no history of hypertension in these 4 patients, but 1 (1/4) of these 4 patients had diabetes. Six patients were taking ACEI and/or ARB in combination with their diuretic, calcium channel blocker and beta blocker. Only one patient was taking calcium channel blocker and beta blocker. Conclusions: The risk of severe pneumonia may increase in COVID-19 positive patients using any antihypertensive drug. It was more pronounced in those using ACEI and ARB. We believe that more comprehensive studies are needed in this about.
Selected methods of conservative treatment in painful hallux valgus therapy

Hallux valgus is one of the most common deformities within forefoot region. Reasons for this deformity are not entirely clear. The available literature lists both internal and external factors. Researchers dealing with hallux valgus emphasize that this deformation is accompanied by pain, reduced quality of life, changed foot statics, cosmetic problems and problems with buying the right footwear. The occurrence of pain may significantly affect the quality of everyday functioning and the broadly understood quality of life. The purpose of the following publication is to review selected interactions in the area of physiotherapy and orthopedic measures in the therapy of people reporting pain within the hallux valgus region.
Frequency of tramadol toxicity in Shahid Mohammadi Hospital in Bandar Abbas

Background: Tramadol is a synthetic drug with central mechanisms which binds to µ-opioid receptors. Recently, increased consumption and serious complications have been reported about this drug. Thus, the aim of this study was to determine the frequency of tramadol toxicity in Shahid Mohammadi Hospital in Bandar Abbas. Materials and Methods: This retrospective descriptive study was performed on individuals with tramadol toxicity admitted to Shahid Mohammadi Hospital, Bandar Abbas during 2013- 2014. Information was collected through patients’ medical files using a checklist including demographic characteristics, toxicity complications, and patients’ clinical outcomes. The acquired data were then analyzed using SPSS software. Results: The mean age of 53 patients was 24.71±7.76 years, of which 69.8% were males and 49.1% had a history of drug abuse. In addition, the seizure was observed in 49.1% of them, and 47.2% of cases simultaneously used another drug, along with tramadol. Further, the history of mental disorders was reported in 24.5% of patients. Clinical manifestations included a decreased level of consciousness (49.1%), nausea and/or vomiting (45.3%), and headache (30.2%). Furthermore, the duration of hospital stay was 48 hours in 90.6% of patients. Eventually, a significant correlation was found between seizure and drugs other than tramadol (P=0.001), gender (P=0.004), and occupation (P=0.010). Conclusion: Most cases of tramadol toxicity occur in students and young adults, resulting in complications such as seizure, decreased levels of consciousness, and nausea and/or vomiting. Accordingly, awareness of the complications of tramadol and meticulous observations over its methods of delivery could reduce the associated harms.
GROWTH, YIELD AND POST-HARVEST EVALUATION OF LETTUCE PLANTS SUBJECTED TO DIFFERENT LEAF SILICON CONCENTRATIONS

Lettuce is considered the most produced and consumed leafy vegetable; however, it has short post-harvest life, which generates significant losses for both producers and consumers. Studies have proven the beneficial effect of silicon on fruits and vegetables. Therefore, the aim of the current study is to evaluate the influence of leaf calcium silicate application on the growth, biomass production and postharvest conservation of curly lettuce. The experiment was carried out in greenhouse at Federal Rural University of Amazonia, Parauapebas Campus / PA. It followed a completely randomized design (CRD) with five Si concentrations (0.0, 2.0, 4.0, 6.0 and 8.0 mg L-1) and eight repetitions, which totaled 40 plants. Plants were grown in plastic pots (capacity = 3 dm) filled with soil classified as Red-Yellow Argisol. Different Si concentrations were applied to plant leaves, at the 20 and 27 days after transplantation (DAT). Silicon has favored the growth and development of lettuce plants, as well as reduced their post-harvest weight loss. It was possible concluding that the herein tested Si concentrations, which were applied to leaves in the form of calcium silicate had beneficial effect on lettuce plants.
Clinical and electroretinographic profile of 27 patients with Stargardt disease treated at a hospital in Brazil.

PURPOSE Stargardt disease is the most common type of juvenile-onset macular dystrophy. It is bilateral and symmetrical in appearance, affects the macula, and its main characteristic is the loss of central vision that starts in the first or second decade of life. The purpose of this study was to describe the profile of the patients evaluated at the Complexo Hospital de Clínicas da Universidade Federal do Paraná, as well as describe the electroretinographic findings with the full-field electroretinogram in these patients. METHODS An observational, retrospective study was performed by analysis of records and electroretinographic examinations of 27 patients with Stargardt disease and fundus flavimaculatus who were treated at the Complexo Hospital de Clínicas da Universidade Federal do Paraná's Department of Ocular Electrophysiology and Neuro-Ophthalmology between 1997 and 2014. The patients included in this study presented clinical features, fundus examination and/or electroretinographic findings compatible with Stargardt disease. RESULTS The visual acuity in the best eye varied from 0 to 1.6 logMAR (20/20 to 20/800) with an average of 0.89 ± 0.42 logMAR. The age at onset of symptoms varied from since birth to 36 years old (average 19.2 ± 9.2) with the majority of patients having symptom onset in the first or second decade of life. The mean time from the disease's first symptoms until the diagnosis was 7.3 years. In the fundus examination, every patient presented some kind of abnormality. In the electroretinogram analysis, the majority of patients had results that differed from those of sample controls, i.e., reduced amplitude and increased implicit time in the photopic and scotopic phases. CONCLUSIONS The visual acuity and the age at symptoms onset in this study were compatible with the natural history of this dystrophy. The typical fundus appearance of Stargardt disease and altered electroretinogram were more frequent because of the delay until diagnosis. New prospective studies are necessary to evaluate these patients based on emergent technologies.
An integrated approach to assessing students’ emotional stability under the COVID-19 pandemic

In contemporary unpredictably threatening environmental conditions, many students, like individuals of other walks of life who realise the potential danger of corona virus disease for their health and even life, are likely to experience higher than usual levels of emotional stress and consequent behavioural changes, like proneness to self-handicapping, escapism, giving preference to avoidance-type of coping strategies etc. This article presents the description and the expediency of using, for the monitoring of the emotional states of the students, a computer-assisted technique for assessing the mode of information processing preferred by the individual in the stressful conditions. The unified holistic-synthetic mode is found to be pertinent to emotionally stable individuals and consecutive analytical ones compared to the emotional vulnerable ones. The technique can be used for monitoring the emotional states of students and accounting for them in the process of teaching.
Anchoring among German financial analysts: An empirical and background analysis

The paper investigates whether financial analysts in Germany were subject to cognitive and emotional constraints. The focus was on the heuristic of anchoring. An evaluation based on 224 individual forecasts for seven DAX-listed companies for the period from 2011 to 2018 with respect to the earnings per share of the current business year was done. Three issues were analysed in particular: Whether anchoring was found at all, to what extent anchoring has led to a deterioration of the forecast quality and if the effect of anchoring was still measurable shortly before the incurred earnings had been announced. For the assessment of the data, descriptive statistical measures, and tests such as the non-parametric Wilcoxon rank-sum test or the parametric t-test were used. For the German capital market there are currently very few empirical behavioural studies dealing with the forecast quality of financial analysts. This study is aiming to close this gap by investigating to what extent behavioural aspects have led to a significant deterioration in the forecast quality of financial analysts for the German stock market. The quality and reliability of analysts' forecasts is of high relevance to the capital market, since the assessments of financial analysts are used as a basis for investment decisions by private and institutional investors and are thus essential for a high degree of efficiency in the allocation of capital in a financial system.
Occupational Stress and Satisfaction of NSW Department of School Education Teachers 1

Introduction Stress is not experienced uniformly by groups of people, but rather personally by an individual (Albertson and Kagan, 1987; Worrall and May, 1989; Dworkin et al., 1990; Pierce and Molloy, 1990). Stress may be considered as a product of the individual's interaction with the environment or social setting (Lazarus and Folkman, 1984; Fleishman, 1984; Worrall and May, 1989; KremerHayon and Goldstein, 1990). Moreover, a distinction should be drawn between negative "distress" and positive "eustress" (Selye, 1976; Milstein and Farkas, 1988; Pierce and Molloy, 1990). The latter relates to stress which is stimulating and associated with positive feelings. When one considers stress in such general terms, one concludes that it is an inevitable part of life (Selye, 1976). However, such a generalised view is not adequate if we are to attain a better understanding of the nature of occupational stress, and particularly, the occupational stress of teachers.
Localizing Vulnerabilities Statistically From One Exploit

Automatic vulnerability diagnosis can help security analysts identify and, therefore, quickly patch disclosed vulnerabilities. The vulnerability localization problem is to automatically find a program point at which the "root cause" of the bug can be fixed. This paper employs a statistical localization approach to analyze a given exploit. Our main technical contribution is a novel procedure to systematically construct a test-suite which enables high-fidelity localization. We build our techniques in a tool called VulnLoc which automatically pinpoints vulnerability locations, given just one exploit, with high accuracy. VulnLoc does not make any assumptions about the availability of source code, test suites, or specialized knowledge of the type of vulnerability. It identifies actionable locations in its Top-5 outputs, where a correct patch can be applied, for about 88% of 43 CVEs arising in large real-world applications we study. These include 6 different classes of security flaws. Our results highlight the under-explored power of statistical analyses, when combined with suitable test-generation techniques.
Estimation of Genetic and Non-Genetic Factors Influencing Growth Traits Performance of Egyptian Buffalo العوامل الوراثیة وغیر الوراثیة التی تؤثر على صفات النمو فی الجاموس المصری

The current study aimed to estimate genetic parameters for body weight traits and daily weight gains of Egyptian buffalo. Impacts of sex, season and year of calving as fixed effects on these criteria are also included in the study. The present study was carried out on buffalo herd maintained at Mostorod Station of Animal Aroduction, Faculty of Agriculture, Al-Azhar University of Egypt. Records of 91 calves (39 males and 52 females) produced from 3 Sires and 91 Dams were used for the study.These calves were born between 2010 and 2015. Parameters of the body weights and average daily weight gain were done for each calf. The effects of sex (male and female), year (2010 to 2015) and the calving seasons (summer and winter) were estimated for the previous parameters. The overall means for birth (BW), weaning(WW)and yearling weights(YW)were 33.26, 93.85 and 208.47 kg, respectively. Male calves had higher significant body weights at WW and YW than female calves. Season of calving had no significant effect on the body weights at different ages. Calving year had significant effect on BW, WW and YW. Heritability estimates (h) were recorded as moderate for BW (0.22) and WW (0.20), and high for YW (0.73). Conclusions: Heritability estimate levels recorded in this study were ranged from medium to high; this means that Egyptian buffalo possesses potential for growth and therefore the possibility to improving growth performance in this herd can be achieved through an organized breeding selection program with appropriate systems linked to nutrition and management.