Miracle-dz/UniFAR-FTUs huggingface dataset:
Epithelial and Stromal Ron Receptor Expression Promotes Tumor Growth in a Murine Model of Prostate Cancer

2 Introduction 2 Biology of the RON/HGFL axis 3 Ron structure and expression 3 The Ron Ligand HGFL Structure And Expression 5 Mouse models of Ron and HGFL 5 Cell and context specific function roles of RON receptor 9 HGFL/RON signaling in macrophages 9 RON /HGFL signaling in epithelial cells 15 Intersection of the cell type specific functions of RON/HGFL 17 RON/HGFL pathway as a therapeutic target 19 Chapter 2 RON RECEPTOR TYROSINE KINASE EXPRESSION IN EPITHELIAL CELLS PROMOTES PROSTATE TUMOR GROWTH AND IS ASSOCIATED WITH AN INCREASE IN PELVIC BONE METASTASIS 27 Part of this work is published in Oncogene. 2010 Jan 14; 29 (2): 214-26. Abstract: 28 Introduction 28 Materials and Methods 29 Results 31 Ron is expressed and functional in murine prostate cancer cell lines 31 Ron expression in epithelial cells is important for prostate tumor growth and increases pelvic bone metastasis 32 Discussion 33 28 Introduction 28 Materials and Methods 29 Results 31 Ron is expressed and functional in murine prostate cancer cell lines 31 Ron expression in epithelial cells is important for prostate tumor growth and increases pelvic bone metastasis 32 Discussion 33 Chapter 3 MYELOID-SPECIFIC EXPRESSION OF RON RECEPTOR KINASE PROMOTES PROSTATE TUMOR GROWTH This work is published in Cancer Research 2013; 73: 1752-1763. 39 Published Online First January 17, 2013. Abstract 40 Introduction 41
Myelodysplasia after Autologous Stem Cell Transplantation for Multiple Myeloma.

Autologous stem cell transplantation (ASCT) increases the overall survival of patients with newly diagnosed multiple myeloma (MM), and it has become standard of care in this setting. Long-term survivors of ASCT transplanted for lymphoma or Hodgkin’s disease are known to have a high risk of developing myelodysplasia (MDS), but the risk of MDS is not clear for patients transplanted for MM. From 1996 through 2005, 82 patients underwent ASCT for MM at our center, survived at least 6 months and have adequate documentation of follow-up for review. The group included 47 males and 35 females of median age 56 years (range, 37–74 yrs). Median time from diagnosis to ASCT was 8.2 mos (range, 2.6–86.1 mos). Prior to coming to transplantation, 28% had received melphalan (MEL), 98% received some form of chemotherapy, and 34% received radiation. This prior therapy included 1 or 2 regimens for 48% of the patients, and more than 2 regimens for 52% of patients. Mobilization was effected using CYC plus growth factor for 79% of the patients, CAD or VAD plus growth factor for 17%, and growth factor alone for 4%. The median mobilization rate was 28.7 × 106 CD34/L blood processed (range, 2.0–250.1 × 106 CD34/L blood processed). A single ASCT was provided for 68%, and 32% underwent ASCT more than once. High-dose MEL alone was used as the preparative regimen for 83%, and the remainder received at least one ASCT with a more intensive preparative regimen. The median CD34 dose for the first ASCT was 5.1 × 106/kg (range, 0.4–113.0 × 106/kg). Nine patients developed MDS. The 5-yr actuarial risk was 26% (95% CI, 8–43%). On multivariate analysis, there was a trend for an increased risk of developing MDS with a CD34 cell dose <3 × 106/kg (HR 3.0, 95% CI 1.0–16.2, p=0.059), but there were otherwise no significant prognostic factors. Eight of the 9 patients with MDS had a PR or better as the best response to ASCT for MM. Five of the MDS patients had relapse of MM as well. Median survival after the diagnosis of MDS was 18.1 mos. Five patients with MDS have died, two from recurrent myeloma, two from AML, and one from sepsis and MDS. The median survival for all patients was 51.7 mos from ASCT and 69.1 mos from diagnosis, and there were no differences in survivals between those with or without MDS. We conclude that there is a relatively high risk of MDS after ASCT for MM, but development of MDS does not appear to worsen overall survival.
HEART ELECTRICAL AXIS α ANGLE VALUES DISTRIBUTION IN PATIENTS, UNDERGOING PERMANENT PACEMAKER IMPLANTATION

52 patients (24 male and 28 female) aged 71 ± 8 years, underwent permanent pacemaker implantation were included in the study. Analysis of heart electrical axis (HEA) α angle values distribution was carried out in three dimensions in patience before and after pacemaker (PM) implantation. The data processed in Microsoft Excel with calculation of the average and it’s standard deviation. Significance of differences in data before and after PM implantation was assessed using Friedman ANOVA test and Kendall concordance coefficient. It was found, that α angle values distribution in patients with implanted PM is transformed from a unimodal to bimodal on the permanent cardiac pacing background. It’s assumed, that α angle changes resulting due to right ventricular electrode positioning options during PM implantation. Clarification of the nature of this change requires a special study.
Quality of Healthcare Provided to Elderly with Type 2 Diabetes: Data from the AMD* Annals Initiative

Objectives: The present study aims at exploring current approaches of Italian diabetologists, with regards to fundamental parameters in quality of care of elderly patients with type II diabetes, focusing at the same time on existing critical areas. Research project and methodology: The results of clinical data, gathered during year 2009, were extracted from electronic medical records. The following parameters, taken from a source population of elderly people with diabetes aged ≥ 65 years, were assessed: glycated haemoglobin (Hb1Ac); renal function; lipid profile; arterial blood pressure; foot and eye examination. In addition, specific favorable and unfavorable outcomes of therapeutical intervention were also evaluated. Results: We assessed a total of 414,814 patients with type II diabetes in 236 diabetic centers; 39.9% were aged 74 years. We observed a high adherence to guidelines in the measurement of Hb1Ac regardless of age, while there was a shortage in the frequency of detection of the lipid profile and blood pressure in the elderly patients. Similarly, there was a significant reduction in the percentage of patients monitored for microalbuminuria, foot and retinopathy with increasing age. In 11% of elderly patients, Hb1Ac levels were >9%, whereas in 24.9% Hb1Ac was <6.5. A poor lipid control was observed in about 30% of elderly patients, while the percentage of older patients lacking an optimal blood pressure control was more than twice. Conclusions: As a whole, Italian diabetes care centers seem to provide a different quality of care to elderly type 2 diabetic patients compared to younger individuals. The data call for a higher attention for this class of frial subjects for the definition of reference objectives for elderly people.
Current Legal Framework on Shallow Geothermal Energy Use in Spain

A steady increase in the use of shallow geothermal energy can be observed worldwide in past years. In order to highlight the necessity of a specific detailed legal framework for shallow geothermal energy systems, an overview of the current legal framework in Spain is carried out in this paper. Findings show complex legislation at the national level and a high diversity among regional governments in Spain. There is no legally binding definition of shallow geothermal energy resources and the deep geothermal approach of the past is embedded in the legislation inherited from 40 years ago. In consequence, the lack of specific legislation makes the licensing process of systems an effective barrier for the further development of the market, thus indicating the need for a common approach. This work highlights the need for a shallow geothermal energy management framework structure and a governance model based on an adaptive management approach, including both management planning and implementation as well as control cycles.
Comparative study between caudal dexmedetomidine with bupivacaine versus ketamine with bupivacaine for postoperative analgesia after inguinoscrotal surgery in pediatric patients

Objectives The aim of this randomized, double-blinded study was to compare the duration of postoperative analgesia and sedation, and the incidence of any side effect of single-dose caudal dexmedetomidine with bupivacaine versus ketamine with bupivacaine in pediatric patients undergoing inguinoscrotal surgeries. Patients and methods A total of 60 pediatric patients, 2-5 years of age, American Society of Anesthesiologists physical status I or II, scheduled for inguinoscrotal surgeries were included in the study. The patients were divided into two equal groups: group A patients (n = 30) received dexmedetomidine with bupivacaine, whereas group B patients (n = 30) received ketamine with bupivacaine. For each patient, postoperative sedation score, pain score, duration of analgesia, and postoperative complications were recorded. Results The duration of postoperative analgesia was longer in group A than in group B, and sedation score was lower in group B than in group A, which was statistically significant. No significant postoperative complications were recorded in both groups. Conclusion The use of dexmedetomidine, as an additive to the local anesthetic bupivacaine in caudal epidural analgesia, during single-dose injection, prolonged the duration of postoperative analgesia following inguinoscrotal surgery compared with caudal administration of ketamine with bupivacaine, but with more sedation compared with ketamine. Both groups showed few side effects.
Development Undone: Weber, Kafka and the Organisation of Supply-Side Vested Interests

Based on primary empirical evidence from six Asian countries at different stages of development, it is argued, first, that at the national point of delivery supply-side development assistance, organisations routinely behave in a manner that is antithetical to development, contradict their stated intentions and the principles of good governance that they claim to uphold (bureaucratic misrepresentation and anomie) and waste resources on technical ‘remedies’ that they know to be ineffective (bureaucratic misdirection); second, that these things are done to serve national and/or personal vested interests on the supply-side; third, that this can lead to internal conflict and alienation in supply-side organisations; fourth, that contrary to conventional wisdom, in many ways, supply-side behaviour mirrors the behaviour of vested interests on the demand-side and that they are mutually reinforcing; fifth, that Kafka’s notion of organisation explains such supply-side and demand-side behaviour much better than Weber’s does and sixth, that the dominance of neoliberal and Weberian thinking in our political and educational institutions and the Kafkaesque nature of development agencies at the national level make it likely that development in the interests of poor people by well-intentioned and well-informed technocrats will continue to be severely curtailed. JEL: F35, F51, F54, F55 O19, O57, P48
Innovative Leadership Characteristics of Manufacturing SMEs in kwazulu-Natal

Manufacturing SMEs are confronted with various challenges, which have fundamentally influenced their growth and development, and, as a result, many have been forced to close down in recent years. The lack of a serious focus on sustainability within the manufacturing SME sector is generally attributed to the entrepreneurial characteristics of SMEs’ and entrepreneurs who often lack the awareness, expertise, skills, financial support, and qualified personnel required to build the changes required for sustainable growth within the an organisation. The conception of this study was based on a quantitative research approach. Business leadership, owners, managers in the manufacturing SMEs in KwaZulu-Natal were identified as the target population for this study. A nonprobability (quota) sampling techniques was used to identify the sample size of 384. Primary data were collected using questionnaires and were analysed using SPSS version 24.0. The empirical finding of the study significantly identified that entrepreneurial characteristics, specifically ICT support, lengthy financial institutional processes, shortage of government financial assistance were critical drawbacks to innovative leadership effectiveness. The study concluded that innovative leadership need to urgently invest in appropriate technological advances as, across the globe, innovations involve the need to go through revolutionary changes (frequently technological) in order to be aligned with the current business dynamics.
Relationship between social support and breastfeeding self-efficacy among women in Tabriz, Iran

Background Breastfeeding self-efficacy depends on various psychological, physiological, and social factors. Aims This study aimed to determine the relationship between social support and breastfeeding self-efficacy in women referred to health centers in Tabriz, Iran, during 2015. Methods A cross-sectional study was carried out on 220 breastfeeding mothers with infants aged 4–6 months. Data were collected using social support (PRQ-85) and breastfeeding self-efficacy questionnaires. The general linear model was applied to control for confounding variables and determine the relationship between social support and breastfeeding self-efficacy. Findings The mean (standard deviation (SD)) breastfeeding self-efficacy was 138.7 (11.9) of a range of 33–165, about 90% of women had high breastfeeding self-efficacy. The mean (SD) social support score was 141.2 (19.6) of a range of 25–175. Social support was one of the predictors of breastfeeding self-efficacy (P = 0.004), after adjusting for sociodemographic character.
Domestic wastewater treatment by vertical filter planted with Papyrus Cyperus: the plant adaptation in the new environment

The wastewater from rural areas or small agglomerations usually discharged in an unsuitable manner requires an appropriate treatment. The constructed wetland has revealed a great potential due to the good performance, reasonable investment and easier management. The aim of this article is to present the results of the adaptation period (45 days) of a substitute plant, Papyrus Cyperus, in the new environment. Investigations were carried out on a concrete vertical filter of 12 m2 filled with gravel available on the local market. Monitoring was provided mainly through two squares of 1 m2 each. The results were compared with a control square planted in natural soil. The filter and the control square were planted with a density of 3 plants / m2 and were fed by necessary water needs. At the completion of the adaptation phase, the density increased by 26 stems at each Square of the filter. The stems exceeded 1 m in height (Square 1: 110 cm ± 0.9, Square 2: 123.5 cm ± 0.7 and control Square: 113 cm ± 0.9). The mean perimeter exceeded 5 cm at the filter (square 1: 5.6 cm ± 0.5 and square 2: 5.5 cm ± 0.1) and almost 4 cm in the control square (3.7 cm ± 0, 2). The shoots reached during the last half of the adaptation period 20 shoots in the Squares of the filter and 16 shoots in the control square. It should be noted that the young stems are adapted quickly than the older ones. Papyrus Cyperus plants have completed this phase with good health (absence of disease symptoms) and organ development similar to control plants.
Anti-cancer and chemopreventive efficacy of grape seed extract against head and neck squamous cell carcinoma through cellular metabolism

Grape seed extract (GSE), rich in proanthocyandins, has been proven to possess anti-cancer and chemopreventive efficacy in various organs associated malignancies. However, the detailed mechanistic insight for its efficacy against head and neck squamous cell carcinoma (HNSCC) are largely unknown. Therefore, the proposed study was designed to thoroughly evaluate a) the molecular mechanism involved in cell growth inhibition and cell death following GSE treatment, b) to determine the molecular mechanism involved in GSE-mediated metabolic oxidative stress and modulation of cellular metabolism, c) to assess the chemopreventive efficacy of GSE in long-term 4nitroquinoline-1-oxide (4NQO)-induced oral carcinogenesis mouse model in HNSCC. Our study for the first time revealed that GSE selectively arrested HNSCC cells at G2/M phase of cell cycle by activating DNA damage check-point kinases, decreasing the expression of DNA repair enzymes expression, and facilitating apoptotic cell death. GSEinduced increased accumulation of intra-cellular reactive oxygen species (ROS) was identified as a major mechanism involved in cell viability, DNA damage and apoptosis of HNSCC cells. These preliminary observations laid a foundation for second part of the proposed study, where we investigated the mechanism involved in accumulation of
Correlation of hematological parameters in Malaria positive cases-A retrospective study in rural Melmaruvathur, South India

Background: Malarial infection is endemic in many countries of Asia, South Pacific, North Africa, Middle East and South and Central America. It is well known that it affects the haemopoietic physiology and induces changes in hematological parameters. Objectives: This study was undertaken to know the prevalence of malarial infection in this rural area of Melmaruvathur, South India and to assess the changes in hematological parameters in malaria positive individuals. Materials and Methods: This was a retrospective study carried out in Melmaruvathur Adhiparasakthi Institute of medical sciences hospital atMelmaruvathur. Hematological parameters of all malaria positive cases who visited the hospital during the year 2012-2015 were collected and statistically analyzed along with demographic data. Results and Observations: A total of 60 cases were recorded during the year 2012-2015. Males were commonly affected in this rural area. The mean age of the patients was 33.57 with standard deviation 14.96. Out of these 60 cases, plasmodium vivax affected 55 cases and only five cases were found affected by Plasmodium falciparum infection. Thrombocytopenia was observed in 97% of infected individual and it was significant in Plasmodium vivax infection (p=0.017). Mild thrombocytopenia was noted in 75% of cases and moderate thrombocytopenia was observed in 21.7% of cases. Anemia was noted in 30% of affected individuals and significant anemia was observed in Plasmodium falciparum infection (p=0.003). Conclusion: The frequency of malaria was found less common in this rural area. Thrombocytopenia was the common hematological finding and next to that was mild degree of anemia among malaria patients.
Effects of Glass Ceiling on Women Career Blooming in Sri Lankan Academic Sector

The term Glass Ceiling (GC) refers to an invisible barrier that hinders and blocks women from being promoted to higher managerial level positions. This study is wholly focused on the central problem of the effects of Glass Ceiling on Women Career Blooming. The research problem marked under the study is to find out the effects of Glass Ceiling on women Career Blooming, in the Sri Lankan academic sector. The structure of this study was entirely designed according to the conceptual framework, created using information from past literature. Level analysis is used to discover whether there is an effect of Family Factors, Organizational Factors, Individual Factors and Educational Factors on Women Career Blooming. The sample of the study consists of 214 women lecturers from two selected universities. Data were collected in the form of a structured questionnaire and six interviews were conducted. Regression and level analysis were used to analyze the gathered data. Research findings reveal that Glass Ceiling and Women Career Original Research Article Lakmali et al.; SAJSSE, 5(4): 1-12, 2019; Article no.SAJSSE. 53480 2 Blooming have a negative relationship. Furthermore, the findings reveal that family and organizational factors have a significant effect on women Career Blooming and individual and educational factors have a moderate effect on women Career Blooming. By taking into consideration the research findings of the study, suggestions for future studies, limitations of the study and future recommendations have been made.
Bureaucratic Theory and Its Influence on Workers' Productivity Improvement in Nigerian Universities

The study examined the contribution of bureaucratic theory to workers’ productivity improvement in Nigerian universities. A descriptive research design of the survey type was used for the study. A sample of 10 universities in the south west Nigeria – five state-owned and five federal-owned – using simple random sampling technique was selected. Also, simple random sampling was used to select 20 respondents including academic and non-academic staff (senior staff) amounting to 200 respondents. The study developed and used a questionnaire titled: “Bureaucratic Principles and Workers’ Productivity Questionnaire (BPWQ)” with a reliability correlation coefficient (r) of 0.90. Multiple regression analysis was employed to analyse the data, while the null hypotheses developed for the study were tested at . 05 level of significance. The findings revealed that there was significant composite influence of bureaucratic principles on workers’ productivity improvement in Nigerian universities. Also, there was significant influence of division of labour and specialization, hierarchy of authority, stipulated rules and regulation, records, impersonal orientation, and employment and promotion of staff based on technical competence on workers’ productivity improvement in Nigerian universities. It is therefore recommended among others that skilful and qualified workers should be employed at every level in Nigerian universities, their appointments and promotions should be based on merit and competence as established by bureaucratic principles.
Mars' Ionospheric Interaction With Comet C/2013 A1 Siding Spring's Coma at Their Closest Approach as Seen by Mars Express

On 19 October 2014, Mars experienced a close encounter with Comet C/2013 A1 Siding Spring. Using data from the Mars Advanced Radar for Subsurface and Ionosphere Sounding (MARSIS) on board Mars Express (MEX), we assess the interaction of the Martian ionosphere with the comet's coma and possibly magnetic tail during the orbit of their closest approach. The topside ionospheric electron density profile is evaluated from the altitude of the peak density of the ionosphere up to the MEX altitude. We find complex and rapid variability in the ionospheric profile along the MEX orbit, not seen even after the impact of a large coronal mass ejection. Before closest approach, large electron density reductions predominate, which could be caused either by comet water damping or comet magnetic field interactions. After closest approach, a substantial electron density rise predominates. Moreover, several extra topside layers are visible along the whole orbit at different altitudes, which could be related to different processes as we discuss.