Miracle-dz/UniFAR-FTUs huggingface dataset:
Effect of Repeated Intravitreal Injections in Glaucoma Spectrum Diseases

Purpose To evaluate whether repeated intravitreal injections (IVI) with an anti-vascular endothelial growth factor (anti-VEGF) agent are associated with glaucomatous progression in eyes with glaucoma spectrum diseases (GSD). Methods Single-center, retrospective, longitudinal study of patients with bilateral and similar GSD who: (1) received ≥8 IVI in only one eye during the study period; (2) had ≥2 retinal nerve fiber layer thickness (RNFL) measurements obtained by spectral-domain optical coherence tomography (SD-OCT) at least 12 months apart. The primary outcome was the absolute RNFL thickness change, comparing injected and fellow uninjected eyes. Linear mixed effects models were constructed, including a multivariable model. Results Sixty-eight eyes from 34 patients were included, 34 injected and 34 fellow uninjected eyes. Average baseline age was 67.68±21.77 years with a follow-up of 3.66±1.89 years and 25.12±14.49 IVI. RNFL thickness decreased significantly from 80.92±15.78 to 77.20±17.35 μm (p<0.001; −1.18±1.93 μm/year) in injected eyes and from 79.95±17.91 to 76.61±17.97 μm (p<0.001; −1.07±0.98 μm/year) in uninjected eyes. In a multivariable linear mixed model of injected eyes, only higher baseline RNFL thickness (p < 0.001) significantly predicted higher absolute RNFL thickness loss. Neither absolute RNFL thickness variation (p=0.716) nor RNFL rate (p=0.779) was significantly different between paired injected and uninjected eyes. Absolute IOP variation was not significantly different between groups (16.62±4.77 to 15.09±4.34 mmHg in injected eyes and 17.68±5.01 to 14.50±3.39 mmHg in fellow uninjected eyes; p=0.248). The proportion of eyes receiving glaucoma medical treatment increased significantly in both groups (55.9% to 76.5% in injected eyes; p=0.039; 58.8% to 76.5% in uninjected eyes; p = 0.031). The number of glaucoma medications also increased significantly in both groups (1.03±1.11 to 1.59±1.18 glaucoma medications in injected eyes; p=0.003; 1.09±1.11 to 1.56±1.19 glaucoma medications in uninjected eyes; p=0.003). Conclusion Repeated IVI do not seem to accelerate glaucomatous progression. Future studies with a longer follow-up are needed.
The World Gymnaestrada - a Non-Competitive Event

During the twentieth century, large, non-competitive Gymnastics festivals were held in Europe. An early festival of this kind was the 1939 Lingiad, which was held in Stockholm and based on the principles of Ling gymnastics. A later variation that is still going today is the World Gymnaestrada, which is based on the principle of ‘Gymnastics for All’. The aim of this study is to highlight the concept Gymnastics for All and, above all, to examine whether it contains any elements of Ling gymnastics. Three pairs of opposing concepts, general–elite, collectivism–individualism, and modesty–ambition, have been used for this task. The study is based on twenty group interviews and eighty-seven observations. The results show that one similarity between the two forms of gymnastics is their non-competitiveness, and another is the view of collectivism and general, namely that gymnastics should be performed together and the idea behind both gives everyone an opportunity to participate. The major difference between the two can be linked to the increased individualization of society during this period. This is shown, for instance, by the fact that many of the participants, young people under the age of twenty-five, despite their participation in the Gymnaestrada hold individual competitions in higher esteem than group display.
Adaptation and Validation of Nomophobia Instrument (NMP-Q) in the Indonesian Version

Type of nomophobia emerges from the prevalence of excessive use of smartphones. The Nomophobia Instrument (NMP-Q) has been adapted across several countries and languages. Still, there have been few studies that have adapted and tested the psychometric properties of the NMP-Q. Thus, this study aimed to linguistically and culturally adapt and validate the Indonesian version of NMP-Q (NMPQ-10). The adaptation process involved experts in language and psychology. The NMPQ-10 in the Indonesian version was validated by involving 276 college students from public universities in Indonesia aged 17 to 24 years old. The results revealed that empirical data supported the overall measurement model of NMPQ-10. The internal structure of NMPQ-10 in the Indonesian version was similar to that of the original version. The Indonesian version of NMPQ-10 also had high psychometric properties, as indicated by the composite reliability (CR) of 0.932 and a Cronbach Alpha of 0.97. Both were classified as high and evident in internal structure (satisfactory construct validity and convergent validity). This study has important implications for counseling practice, as counselors can use the NMPQ-10 to identify individuals experiencing high levels of nomophobia and guide interventions and treatment plans accordingly. In conclusion, the Indonesian version of NMPQ-10 can be utilized to assess nomophobia among college students. Further studies are needed to include a larger sample to improve the validation of NMPQ-10.
PROVENANCE AND ANATOMY OF GENYODECTES SERUS, A LARGE-TOOTHED CERATOSAUR (DINOSAURIA: THEROPODA) FROM PATAGONIA

Abstract The type material of Genyodectes serus, the first unquestionable non-avian theropod dinosaur to be described from South America, is redescribed in detail and its provenance and systematic position are discussed. Although no detailed information about the provenance of the specimen exists, it is probably derived from the lower part of the Cerro Barcino Formation (Chubut Group; Aptian-Albian) at Cañadón Grande, central Chubut Province, Argentina. Genyodectes is characterized by closely-spaced premaxillary teeth that are arranged in an overlapping en-echelon pattern and extremely transversely compressed maxillary teeth, the longest of which exceed the minimal height of the dentary in apicobasal length. Although systematic information is limited by the fragmentary nature of the material, the combination of fused interdental plates, maxillary and dentary teeth with a pronounced flat or even slightly concave area adjacent to the serrated carinae, premaxillary teeth that are considerably shorter than the maxillary teeth and strongly compressed and very long maxillary teeth indicates neoceratosaurian and, more specifically, ceratosaurid affinities for Genyodectes. Thus, this taxon adds a further lineage of neoceratosaurs to the already diverse South American record of this group.
Understanding progressive tissue loss and wound burden in combat casualties: lessons learnt for future operational capability

Understanding tissue loss following injury is important due to its prevalence among the war-wounded and the impact it has on subsequent treatment and rehabilitation. Progressive tissue loss is a type of tissue loss that has complicated extremity injury in recent conflicts. It has resulted in more proximal residual limb lengths and has influenced rehabilitation. Quantifying wound burden in combat casualties remains a challenge due to poor quality of data sets that lack the capacity for detailed analysis. The aims of this article are to outline the current hurdles in attempting to quantify wound burden in combat casualties and to propose simple interventions to improve data capture for future analysis.
The Influence Of Lifestyle, Brand Image, And Product Design On Smartphone Purchase Decisions (Study On Students In Dki Jakarta)

This study uses a quantitative method with the aim of proving the influence of Lifestyle, Brand Image, and Product Design directly and indirectly on Purchase Decision. This study used 150 respondents from student of Smartphone Top Brand 2023 in DKI Jakarta as primary data, and secondary data researchers obtained through various references related to research. Data were collected using purposive sampling technique and analyzed using descriptive and inferential analysis techniques with the help of SmartPLS software. So that data processing obtains the results that (1) Lifestyle has a positive and significant effect on Purchase Decision, (2) Brand Image has a positive and significant effect on Purchase Decision, (3) Product Design has a positive and significant effect on Purchase Decision, 4) Lifestyle, Brand Image, and Product Design both have a positive effect on Purchase Decision.
Landscape Composition in Aspen Woodlands Under Various Modeled Fire Regimes

Quaking aspen (Populus tremuloides) is declining across the western United States. Aspen habitats are diverse plant communities in this region and loss of these habitats can cause shifts in biodiversity, productivity, and hydrology across spatial scales. Western aspen occurs on the majority of sites seral to conifer species, and long-term maintenance of these aspen woodlands requires periodic fire. We use field data, remotely sensed data, and fire atlas information to develop a spatially explicit landscape simulation model to assess the effects of current and historic wildfire regimes and prescribed burning programs on landscape vegetation composition in the Owyhee Mountains, Idaho. The model is run in the Tool for Exploratory Landscape Scenario Analyses (TELSA) environment. Model outputs depict the future structural makeup and species composition of the landscape at selected time steps under simulated management scenarios. Under current fire regimes and in the absence of management activities, loss of seral aspen stands will continue to occur. However, a return to historic fire regimes, burning 12–14 percent of the modeled landscape per decade, maintains the majority of aspen stands in early and mid seral woodland stages and minimizes the loss of aspen. A fire rotation of 70–80 years was estimated for the historic fire regime while the current fire regime resulted in a fire rotation of 340–450 years. Implementation of prescribed burning programs, treating aspen and young conifer
2023 EULAR recommendations for the management of fatigue in people with inflammatory rheumatic and musculoskeletal diseases

Objectives Fatigue is prevalent in people with inflammatory rheumatic and musculoskeletal diseases (I-RMDs) and recognised as one of the most challenging symptoms to manage. The existence of multiple factors associated with driving and maintaining fatigue, and the evidence about what improves fatigue has led to a multifaceted approach to its management. However, there are no recommendations for fatigue management in people with I-RMDs. This lack of guidance is challenging for those living with fatigue and health professionals delivering clinical care. Therefore, our aim was to develop EULAR recommendations for the management of fatigue in people with I-RMDs. Methods A multidisciplinary taskforce comprising 26 members from 14 European countries was convened, and two systematic reviews were conducted. The taskforce developed the recommendations based on the systematic review of evidence supplemented with taskforce members’ experience of fatigue in I-RMDs. Results Four overarching principles (OAPs) and four recommendations were developed. OAPs include health professionals’ awareness that fatigue encompasses multiple biological, psychological and social factors which should inform clinical care. Fatigue should be monitored and assessed, and people with I-RMDs should be offered management options. Recommendations include offering tailored physical activity and/or tailored psychoeducational interventions and/or, if clinically indicated, immunomodulatory treatment initiation or change. Patient-centred fatigue management should consider the individual’s needs and preferences, their clinical disease activity, comorbidities and other psychosocial and contextual factors through shared decision-making. Conclusions These 2023 EULAR recommendations provide consensus and up-to-date guidance on fatigue management in people with I-RMDs.
Entomotoxic potential of hydroalcoholic extract of Eragrostis plana Nees in experimental model of Nauphoeta cinerea Olivier

The objective of this study was to evaluate the entomotoxic activity of the hydroalcoholic extract of Eragrostis plana Nees in an experimental model of cockroaches (Nauphoeta cinerea Olivier), for a possible bioinsecticide. For this purpose, aerial parts of E. plana were grounded to obtain the hydroalcoholic extract (EACA), after preparing the concentrations of (0.5; 2.5; 5.0; 12.5; 25.0; 50.0 100.0 μg g-1 per animal) a saline solution was used to control the treatment. To determine the receptors and pathways involved in responses to EACA doses of E. plana, a treatment with the drug octopamine and its inhibitor phentolamine were prepared. The effect of EACA on behavioral activities (grooming) and on cardiac activity were tested. All data were expressed as mean ± standard deviation, being analyzed by the two-way ANOVA test, followed by the Tukey test, considered significant when p<0.05. After carrying out the experiment, it was found that EACA induced a significant effect on leg grooming at all concentrations, except for the concentration of 100 μg g-1 per animal, but the same did not modulate antenna grooming. Regarding the receptors and pathways involved, it was observed that octopamine alone and together with the extract, had a significant effect on leg grooming, while phentolamine, together with the extract, influenced antennae grooming. Regarding the effect of the extract on the semi-isolated heart, it was noticed that the same doses that affected grooming, affected heart rate by decreasing it. At no concentration, at the end of the treatment, there was no recovery of the heart rate. The results point to a direct modulation of octopaminergic and cholinergic pathways in the insect nervous system.
Application of Critical Path Method (CPM) and S-Curve on Scheduling Deep Water Well Pump Construction Project in Sorong, West Papua

The difficulty of clean water in Indonesia, especially areas far from the city, resulted in a shortage of drinking water supply for the surrounding communities. CV Ulu Ulu Utomo company engaged in the trade and installation of deep water well pumps for irrigation and industry in the work of the project so far has not used the method of scheduling the project in planning the time and cost required, so there is still a delay in work time and additional costs. Therefore, this study aims to determine the form of network diagram, analyze the optimal time, and estimated total cost of deep well pump construction project in Sorong, West Papua using Critical Path Method (CPM). This research is a type of descriptive and accurate research that systematically describes project activities and data sources obtained from interviews, observations, and documentation. The results of research with Critical Path Method (CPM) showed a network diagram on a series of project activities that are on a critical path is the A1-A2-C2-C4D2-E2 trajectory with a normal time of project completion for 102 days and a cost of IDR 79.353. 000 while the project completion time is accelerated to 91 days over 6 hours at a cost of IDR 82.593. 890.
Mother–Child Conversations of Latina Immigrant and U.S.-Born Mothers in the United States

The present study examined heritage culture influences on the roles of adult and child in the conversations Latina immigrant mothers in the United States have with their young children. Spanish monolingual Latina mothers (n = 17), Spanish-English bilingual Latina mothers (n = 30), and English monolingual European American mothers (n = 22) were recorded in toy play interaction with their 2.5-year-old children; the bilingual Latina mothers were recorded twice, once interacting in Spanish and once in English. Analyses of transcripts of those conversations revealed that the monolingual Spanish-speaking Latina mothers talked more and asked fewer questions of their children and their children talked less compared with the monolingual English-speaking European American mothers and their children, consistent with differences that have been observed between mothers in Latin America and in the United States. The Spanish and English conversations between the bilingual mothers and their children similarly differed in the ratio of adult to child speech, although the Latina mothers’ English conversations still differed from the English conversations of European American mothers. In addition, the ratio of mother to child speech in the immigrant mothers’ Spanish language conversations declined as their years of U.S. residence increased. These findings argue that children of Latina immigrant mothers in the United States are socialized to talk less (and listen more) in conversation with adults compared with children from European American families. These findings also provide new evidence for cultural frames as the mediators of cultural influences on behavior and for language priming of cultural frames.
g-NK cells from umbilical cord blood are phenotypically and functionally different than g-NK cells from peripheral blood

ABSTRACT FcRγ-deficient natural killer (NK) cells, designated as g-NK cells, exhibit enhanced antibody-dependent cellular cytotoxicity (ADCC) capacity and increased IFN-γ and TNF-α production, rendering them promising for antiviral and antitumor responses. g-NK cells from peripheral blood (PB) are often associated with prior human cytomegalovirus (HCMV) infection. However, the prevalence, phenotype, and function of g-NK cells in umbilical cord blood (UCB-g-NK) remain unclear. Here, we demonstrate significant phenotypical differences between UCB-g-NK and PB-g-NK cells. Unlike PB-g-NK cells, UCB-g-NK cells did not show heightened cytokine production upon CD16 engagement, in contrast to the conventional NK (c-NK) cell counterparts. Interestingly, following in vitro activation, UCB-g-NK cells also exhibited elevated levels of IFN-γ production, particularly when co-cultured with HCMV and plasma from g-NK+ adults. Furthermore, g-NK+ plasma from PB even facilitated the in vitro expansion of UCB-g-NK cells. These findings underscore the phenotypic and functional heterogeneity of g-NK cells based on their origin and demonstrate that components within g-NK+ plasma may directly contribute to the acquisition of an adult phenotype by the “immature” UCB-g-NK cells.
The Cost of Equity in Emerging Markets: A Downside Risk Approach (Ii)

Every company evaluating an investment project or an acquisition in an emerging market must not only estimate future cash flows but also an appropriate discount rate. Although not free from controversy, the cost of equity in developed markets is typically estimated with the CAPM. In emerging markets, however, betas and stock returns seem to be unrelated. This article argues that total risk, idiosyncratic risk, and some measures of downside risk are significantly related to emerging-market stock returns, and proposes to estimate costs of equity in these markets based on the semideviation with respect to the mean, a well-known measure of downside risk.
Determinants of Book Built IPO underpricing – differential issue size and market momentum approach revisited

Abstract Pricing of an Initial public offering (IPO) is a complex phenomenon. Price anomalies are commonly observed in IPO markets, especially in emerging markets. Investors perceived underpricing creates undue market momentum during the offer period with an asymmetric effect across different issue sizes. This study examines the determinants of Book Built IPOs underpricing by considering a sample of 180 Book Built IPOs that went public in India between 2011 and 2020. The determinants were verified for differential issue size public offers. Listing day performance was measured using Listing Day-Absolute Return (LD-AR) and Listing Day-Market Adjusted Return (LD-MAR) models. Further, the data obtained was tested for the explanatory capabilities of firm-specific and market momentum factors for underpricing using OLS models. Concerning the differential issue size, the study found a direct relationship between the issue size and underpricing. Dominant underpricing was observed in the case of moderate to large issue size with a linear progressive return, confirming that there was over-optimism on the part of investors. The study’s results also revealed that momentum-specific factors have a significant influence along with firm-specific factors such as firm size, cash flows, a subscription rate of QIBs and RIIs in the listing day return, and underpricing.
GEOMORPHOLOGIC FEATURES OF THE BEACH-DUNE SYSTEM ALONG FUJIAN COAST

Based on the observation of 25main beach-dune systems along the coast of Fujian province and the repeated measurement of typical coastal dune and beach profiles from July 2007to February 2010,we studied the morphodynamics of the beach-dune system and its relation with the coastal hydrodynamic conditions of the macro-tidal environment.It is concluded as follows:(1)the beach-dune morphological changes can be grouped into 3types,①the stable beach with changing dunes,②the erosional beach with stable dunes,and③the erosional beach with retreating dunes;(2)the relationship between beach morphodynamics and dune morphology can be summarized into 6basic types,including three major types of beach superimposed by different dunes.The interaction of dune morphology and sedimentation is also a controlling factor of the beach morphology to certain extent.
Sex-Specific Disparities in Outcomes of Transcatheter Edge-to-Edge Repair for Mitral Regurgitation: A Multicenter “Real-World” Analysis

Background: mitral regurgitation (mr) is the most common valvular heart disease (vhd) in the elderly and tends to be more prevalent in women. while relevant sex differences in outcomes are evident in surgically treated collectives, there are very limited and conflicting sex-specific data for the growing cohort of patients undergoing transcatheter edge-to-edge repair (teer). Objective: to investigate whether sex impacts procedural safety and efficacy, and in-hospital- and long-term outcomes, after teer for mr. Methods: in a multicenter observational cohort study, patients who underwent teer were stratified by sex and relevant outcome measures, and analyzed using multivariable cox regression and propensity score matching (psm). Results: a total of 821 patients were analyzed, of whom 37.4% (307/821) were female. compared to male patients, females were significantly older (77 ± 8.5 vs. 80.4 ± 6.7 years, p = 0.03), and had less coronary artery disease (cad, 67.7% vs. 53.1%, p < 0.0001) and a higher proportion of preserved left ventricular function (lvef > 50%, 32.5% vs. 50.5%, p > 0.0001). safety and efficacy of the teer procedure and in-hospital mortality did not differ between the sexes. after psm, women showed significantly better survival 3 years after teer compared to men (60.7% vs. 54.2%, p = 0.04) and a lower risk of all-cause death according to multiple cox regression (hr 0.8, 95% ci 0.6–0.9, p = 0.02). after sex-specific stratification for concomitant atrial fibrillation (af), the most common comorbidity in the present collective, women with af experience significantly worse adjusted survival compared to women without af (53.9% vs. 75.1%, p = 0.042) three years after teer and lose the survival advantage over men. Conclusions: female patients are older and less comorbid than males undergoing TEER. The TEER procedure is equally safe and effective in both sexes. While in-hospital mortality did not differ, female patients experienced a significantly better adjusted long-term survival compared to male patients. Concomitant AF offsets the prognostic advantage of females over males and, in contrast to males, significantly impairs long-term survival in women undergoing TEER. Further research is warranted to elucidate underlying causes for the observed sex disparities and to develop sex-tailored treatment recommendations.