Miracle-dz/UniFAR-FTUs huggingface dataset:
Can We Compare the Health-Related Quality of Life of Childhood Cancer Survivors Following Photon and Proton Radiation Therapy? A Systematic Review

Simple Summary Proton radiation therapy is a radiation oncology innovation expected to produce superior health-related quality of life (HRQoL) outcomes for children with cancer, compared to conventional photon radiation therapy. The review aim is to identify if clinical evidence exists to support the anticipated HRQoL improvements for children receiving proton radiation therapy. HRQoL outcomes of 1986 childhood cancer survivors are described. There is insufficient quality evidence to compare HRQoL outcomes between proton and photon radiation therapy. Therefore, the current state of the literature does not conclude that proton radiation therapy produces superior HRQoL outcomes for childhood cancer survivors. Despite recommendations, no evidence of routine HRQoL assessment using patient-reported outcomes in paediatric radiation oncology are identified. Further rigorous collection and reporting of HRQoL data is essential to improve patient outcomes, and to adequately compare HRQoL between radiation therapy modalities. Abstract Paediatric cancer patients have a risk of late side effects after curative treatment. Proton radiation therapy (PRT) has the potential to reduce the incidence and severity of toxicities produced by conventional photon radiation therapy (XRT), which may improve the health-related quality of life (HRQoL) in children. This systematic review aimed to identify the evidence of HRQoL outcomes in childhood cancer survivors following XRT and PRT. Medline, Embase, and Scopus were systematically searched. Thirty studies were analysed, which described outcomes of 1986 childhood cancer survivors. Most studies (n = 24) described outcomes for children with a central nervous system (CNS) tumour, four studies reported outcomes for children with a non-CNS tumour, and two studies combined CNS and non-CNS diagnoses within a single cohort. No studies analysed routine HRQoL collection during paediatric radiation oncology clinical practice. There is insufficient quality evidence to compare HRQoL outcomes between XRT and PRT. Therefore, the current state of the literature does not conclude that PRT produces superior HRQoL outcomes for childhood cancer survivors. Standardised clinical implementation of HRQoL assessment using patient-reported outcomes is recommended to contribute to improvements in clinical care whilst assisting the progression of knowledge comparing XRT and PRT.
Modeling the Major Influencing Factor on Match Running Performance during the In-Season Phase in a Portuguese Professional Football Team

The aim of this study was two-fold: (1) to analyze the influence of season phase (i.e., the start of the in-season and mid-in-season) on match running performance in a Portuguese professional football team; (2) to determine and model the main factor influencing match running performance during the in-season in this specific football team. Eighteen matches were collected by an 18 Hz global positioning system (GPS) from a professional Portuguese football team during the start of the in-season and mid-in-season. The match running performance was analyzed according to season phases, presenting significant differences in total distance (TD) (tlower bound = 4.71, p < 0.001; tupper bound = −2.22, p = 0.002), average speed (AvS) (tlower bound = 359.45, p < 0.001; tupper bound = −359.87, p < 0.001), and relative high speed running (rHSR) (tlower bound = 13.10, p < 0.001; tupper bound = −10.21, p < 0.001). The logistic regression showed TD (β = −1.59, z = −2.84, p = 0.005) and AvS (β = 2.68, z = −2.84, p = 0.007) as the major factors influencing match running performance during seasonal variation. Sprints and accelerations showed no significance for predicting match running performance during the season phases (β = −0.05 to 1.07, z = −0.95 to 1.07, p = 0.29 to 0.72). Current research confirms that lower and upper bounds should be used to quantify seasonal differences on match running performance. TD and AvS were described as the main factors influencing match running performance during the in-season phase. Thus, it is important to highlight the pace and volume of the game to maximize match running performance.
SARS-CoV-2 Spike Does Not Possess Intrinsic Superantigen-like Inflammatory Activity

Multisystem inflammatory syndrome in children (MIS-C) is a rare hyperinflammatory disease occurring several weeks after SARS-CoV-2 infection. The clinical similarities between MIS-C and the toxic shock syndrome, together with the preferential expansion of T cells with a T-cell receptor variable β chain (TCRVβ) skewing, suggested a superantigen theory of MIS-C. For instance, recent in silico modelling evidenced the presence of a highly conserved motif within SARS-CoV-2 spike protein similar in structure to the superantigenic fragment of staphylococcal enterotoxin B (SEB). However, experimental data on the superantigenic activity of the SARS-CoV-2 spike have not yet been provided. Here, we assessed the superantigenic activity of the SARS-CoV-2 spike by analysing inflammatory cytokine production in both Jurkat cells and the peripheral blood CD4+ T cells stimulated with the SARS-CoV-2 spike or SEB as a control. We found that, unlike SEB, the SARS-CoV-2 spike does not exhibit an intrinsic superantigen-like activity.
Do Investor Overconfidence and Loss Aversion Drive Saudi Firm Market Performance? The Moderating Effect of Corporate Governance

This study investigated the impact of investor psychological bias on a firm’s market value. In detail, we examined the effect of investor overconfidence (optimism) and loss aversion (pessimism) on firm market value. We also aimed to investigate the moderating effect of corporate governance on the relationship between investor behavior biases and firm market value. This study used a sample of 143 firms listed on the Saudi Stock Exchange over the period from 2012 to 2021. The results suggest that investor overconfidence affects a firm’s value positively. On the other hand, loss aversion is negatively associated with the firm’s market value. Furthermore, we find that corporate governance (measured by board size and board independence) enhances the positive association between overconfidence and firm market value. In contrast, we find that corporate governance seems to marginally mitigate the negative effect of loss aversion.
Evaluation of the Antimicrobial Effect of Pre-Synthesized Novel Antibiotic Electrospun Nanofibers as an Intracanal Delivery Strategy for Regenerative Endodontics: A Randomized Clinical Trial

AIM: The aim of this study is to evaluate the antimicrobial effect of pre-synthesized novel antibiotic loaded electrospun nanofibers and compare it with conventional triple antibiotic paste when used in patients with immature necrotic teeth. METHODS: Antibiotic loaded nanofibers were fabricated by electrospinning. Thirty-four patients with immature necrotic teeth were included in the study. In the first visit, access cavity preparation was performed to obtain the first bacteriological sample (S1). The canals were thoroughly irrigated using sodium hypochlorite 1.5% and a second sampling was performed (S2). Patients were randomly divided into two groups according to the intracanal medicament used: Modified triple antibiotic paste (MTAP) loaded electrospun nanofibers or MTAP paste. At the second appointment, the third samples (S3) were taken. The intracanal bacterial count was determined using the spread plate culture technique. Scanning electron microscopy (SEM) was used to examine the morphology of the fabricated MTAP loaded electrospun nanofibers. RESULTS: Both MTAP nanofibers and MTAP paste resulted in significant reduction of bacterial count after the irrigation step. MTAP nanofibers resulted in significantly higher percent reduction of bacterial count (p < 0.05). CONCLUSIONS: It was concluded that electrospinning technology can be used to fabricate antibiotic containing nanofibers which can results in enhanced disinfection in regenerative endodontic procedures.
Chemical and Physical Ionic Liquids in CO2 Capture System Using Membrane Vacuum Regeneration

Carbon Capture Utilization and Storage technologies are essential mitigation options to reach net-zero CO2 emissions. However, this challenge requires the development of sustainable and economic separation technologies. This work presents a novel CO2 capture technology strategy based on non-dispersive CO2 absorption and membrane vacuum regeneration (MVR) technology, and employs two imidazolium ionic liquids (ILs), [emim][Ac] and [emim][MS], with different behavior to absorb CO2. Continuous absorption–desorption experiments were carried out using polypropylene hollow fiber membrane contactors. The results show the highest desorption behavior in the case of [emim][Ac], with a MVR performance efficiency of 92% at 313 K and vacuum pressure of 0.04 bar. On the other hand, the IL [emim][MS] reached an efficiency of 83% under the same conditions. The MVR technology could increase the overall CO2 capture performance by up to 61% for [emim][Ac] and 21% for [emim][MS], which represents an increase of 26% and 9%, respectively. Moreover, adding 30%vol. demonstrates that the process was only favorable by using the physical IL. The results presented here indicate the interest in membrane vacuum regeneration technology based on chemical ILs, but further techno-economic evaluation is needed to ensure the competitiveness of this novel CO2 desorption approach for large-scale application.
Effects of some plant growth stimulants on yield and yield components of wheat (Triticum aestivum L., Narin cultivar) under saline condition

of some on and yield components Abstract In recent years, spreading environmental stresses such as salinity have had a significant impact on the quantitative and qualitative of agricultural products. In order to investigate the effects of using some plant growth stimulants to improve growth and yield of wheat in saline condition, this experimentwas conducted with seven treatments including 1-control (application of chemical fertilizer based on soil test) 2- first treatment + soil application of 5 kg.ha -1 of humic acid3- first treatment + spraying amino acidsin 5 gr.lit -1 4- first treatment + seed priming of Azotobacter with a concentration of 1% 5- first treatment + foliar application of fulvic acid in 5 gr.lit -1 6-first treatment + foliar applying seaweedin 5 gr.lit -1 and 7- combined treatment (1+2+3+4+5+6) in a randomized complete blocks design in three replications and at two years (2017-2019) in Qom province. The biennial results showed highest seed, straw and biological yield of wheat were obtained in treatment seven, which had a significant difference with another stimulant and control and with 3194, 4993 and 8187 kg.ha -1 , respectively which was 35%, 25% and 30% higher than control. Also, the yield trait, such as plant height, cluster length and tillersplant -1 were the highest in this treatment. It seems that the combined use of growth stimulantshad a significant effects on yield and some yield traits of wheat in saline conditions and it is suggested to investigate the effects of these stimulantsincombinewith 50 and/or 70% out of the recommended fertilizers and as well as the time of applying these stimulants.
Effect of COVID-19 on the Need for and Access to Family Planning among Nigerian Women: Secondary Analysis of an International Survey

During the lockdown, there was a disruption in the provision of and access to family planning (FP) services in developing countries due to the covid 19 pandemic mostly because of restrictions on transportation, border closures, and closure of some healthcare institutions. Aim: This study examined the impact of covid-19 on the need for and access to family planning among Nigerian women and access to family planning among Nigerian women. Methods: Secondary data was used and the dataset was obtained from the COVID-19 Health Services Disruption Survey 2020 conducted by Institute for Health Metrics and Evaluation (IHME), Bill and Melinda Gates Foundation (B, MGF), and Premise Data Corporation. Respondents were women between 15 - 49 years. Data were collected from 12, 354 respondents, and 391 were from Nigeria. Variables were measured immediately before the pandemic and during the pandemic (December 2019 – June 2020). Analysis was done using the IBM Statistical Package for the Social Sciences (SPSS) version 26. To summarize data, descriptive analyses such as mean, frequency, and percentages were used. Proportions were calculated to measure the association between the outcome and the independent variables with a 95% confidence interval. Results: 46.5% of the respondents were 25 years old or younger. The proportion of women who reported needing FP services decreased slightly pre and during the pandemic (12.0% to 11.3%) but it was not statistically significant. There was a 4.7% decrease in accessing FP services which was also statistically significant. Conclusion: This study found a slight decrease in the need for FP. This could be due to movement restrictions or a fear of contracting the virus from clinics, which would discourage people from seeking FP services. Anxiety and psychological stress caused by the pandemic would reduce the desire for sex and influence the perceived need for FP.
The Impact of OKC Exercises and TRX Exercises on Shoulder Joint Proprioception in Overhead Athletes With Shoulder Impingement Syndrome: A Randomized Controlled Trial

Purpose: Sub-acromial impingement syndrome (SAIS) is one of the most common causes of shoulder pain and affects shoulder joint proprioception. The closed kinetic chain (CKC) exercises with sling are more effective and safer than open kinetic chain (OKC) exercises. This study aimed to compare the effectiveness of OKC and total-body resistance exercises (TRX) sling training on shoulder joint position sense (JPS) in overhead athletes with shoulder impingement syndrome (SIS). Methods: This article was a randomized control trial (RCT) study conducted in Kerman City, Iran, in 2019. The research sample included 33 overhead athletes with SIS who were randomly classified into three groups: OKC, sling, and control groups. Joint position sense (JPS) was evaluated in external rotation (ER), internal rotation (IR), and abduction of the dominant arm in the target angle concerning the shoulder range of motion with the Leighton flexometer. The obtained data were analyzed using the analysis of covariance (ANCOVA). Results: The post-intervention results showed that a significant difference was observed between groups (ER, P<0.001; IR, P<0.001; abduction P<0.001). The change in the sling exercises group was significantly higher in ER, and IR, except abduction JPS than in OKC (P=0.001, P=0.001, P=0.235, respectively) and control groups (P<0.001, P<0.001, P<0.001, respectively). Change in the OKC group was significantly higher in ER, IR, and abduction JPS (P=0.001, P=0.019, P<0.001, respectively) than in the control group. The OKC and sling exercise improved the shoulder JPS of overhead athletes with SIS. Conclusion: The study results showed that the sling exercises were more effective than the OKC exercise for the shoulder JPS because these exercises were CKC and performed on an unstable level.
MOCA: A Network Intrusion Monitoring and Classification System

Optimizing the monitoring of network traffic features to detect abnormal traffic is critical. We propose a two-stage monitoring and classification (MOCA) system requiring fewer features to detect and classify malicious network attacks. The first stage monitors abnormal traffic, and the anomalous traffic is forwarded for processing in the second stage. A small subset of features trains both classifiers. We demonstrate MOCA’s effectiveness in identifying attacks in the CICIDS2017 dataset with an accuracy of 99.84% and in the CICDDOS2019 dataset with an accuracy of 93%, which significantly outperforms previous methods. We also found that MOCA can use a pre-trained classifier with one feature to distinguish DDoS and Botnet attacks from normal traffic in four different datasets. Our measurements show that MOCA can distinguish DDoS attacks from normal traffic in the CICDDOS2019 dataset with an accuracy of 96% and DDoS attacks in non-IoT and IoT traffic with an accuracy of 99.94%. The results emphasize the importance of using connection features to discriminate new DDoS and Bot attacks from benign traffic, especially with insufficient training samples.
Audit committee characteristics and financial restatement incidence in the emerging market

This paper discusses issues concerning audit committee characteristics that lead to the occurrence of financial restatements in Malaysian public listed companies (PLCs). The audit committee characteristics were measured using size, independence, frequency of meetings, audit tenure, gender, expertise, age, ethnicity, legal qualifications, and political connections. The data in this study were extracted from the annual reports of 100 firms that had restated their financial statement between 2006 and 2015, and a total of 200 non-restatement firms were matched and observed as control firms. Using univariate and multivariate statistical analysis, the results evince that there is a significant association between audit committee size and frequency of meetings as well as ethnicity and political connections of the audit committee members and the occurrence of financial restatements in Malaysian PLCs. However, the remaining audit committee characteristics show insignificant association with the occurrence of financial restatements. Consistent with Wan Mohammad, Wasiuzzaman, and Nik Salleh (2016), the results show that larger and more rigorous audit committees can strengthen the monitoring role and consequently reduce the occurrence of financial restatements. In addition, the results evince that Malay members in the audit committee have widespread political connections, which negatively affect the decisions by the audit committee, thereby increasing the occurrence of financial restatements.
Antiproliferative Effects of Cynara Cardunculus in Colorectal Cancer Cells Are Modulated by the Circadian Clock

The circadian clock generates 24 h rhythms in behavioural, cellular and molecular processes. Malfunctions of the clock are associated with enhanced susceptibility to cancer, worse treatment response and poor prognosis. Clock-controlled genes are involved in cellular processes associated with tumour development and progression including metabolism of drugs and the cell cycle. Cynara cardunculus, a plant of the Asteraceae family, has been reported to have antiproliferative effects on breast cancer cells. Here, we used the human colorectal cancer (CRC) cell line HCT116 and its knockout variants for different core-clock genes (BMAL1, PER2, NR1D1), to investigate the treatment effect of C. cardunculus lipophilic leaf extract under different clock scenarios. Our results show a direct effect of C. cardunculus on the circadian phenotype of the cells, as indicated by alterations in the phase, amplitude, and period length of core-clock gene oscillations. Furthermore, our data indicate a role for the circadian clock in sensitivity to C. cardunculus treatment. In particular, the treatment inhibited proliferation and induced cytotoxicity and apoptosis in a clock knockout-specific manner, in CRC cells. These results point to a potential effect of C. cardunculus lipophilic leaf extracts as a modulator of the circadian clock, in addition to its anti-proliferative properties.
Modulatory Impacts of Multi-Strain Probiotics on Rabbits’ Growth, Nutrient Transporters, Tight Junctions and Immune System to Fight against Listeria monocytogenes Infection

Simple Summary Weaning is a crucial period associated with great stress and susceptibility to infection, implying adverse impacts on farmed rabbits’ production. Recently, probiotics have been provided as direct microbial feed supplements, which are considered the ideal antibiotic substitutes during pathogenic infections with an emphasis on promoting rabbits’ growth and modulating their immune functions. Therefore, our experiment was carried out to explore the efficacy of multi-strain probiotics (MSP) on rabbits’ growth, molecular aspects, such as nutrients transporters, cytokines, and intestinal integrity, and effectiveness against Listeria monocytogenes (L. monocytogenes) infection. Altogether, our findings proposed the beneficial consequences of MSP on rabbits’ growth, gut health, and immunity. After post-experimental infection of rabbits with L. monocytogenes, administration of MSP during the whole rearing period greatly reduced the detrimental impact of infection and consequently renovated efficient rabbits’ production. Abstract Multi-strain probiotics (MSP) are considered innovative antibiotics’ substitutes supporting superior gut health and immunity of farmed rabbits. The promising roles of MSP on performance, intestinal immunity, integrity and transporters, and resistance against Listeria monocytogenes (L. monocytogenes) were evaluated. In the feeding trial, 220 rabbits were fed a control diet or diet supplemented with three MSP graded levels. At 60 days of age, rabbits were experimentally infected with L. monocytogenes and the positive control, enrofloxacin, prophylactic MSP (MSPP), and prophylactic and therapeutic MSP (MSPTT) groups were included. During the growing period, MSP at the level of 1 × 108 CFU/kg diet (MSPIII) promoted the rabbits’ growth, upregulated the nutrient transporters and tight-junction-related genes, and modified cytokines expression. Supplementing MSPTT for L. monocytogenes experimentally-infected rabbits restored the impaired growth and intestinal barriers, reduced clinical signs of severity and mortalities, and attenuated the excessive inflammatory reactions. Notably, enrofloxacin decreased L. monocytogenes and beneficial microbial loads; unlike MSPTT, which decreased pathogenic bacterial loads and sustained the beneficial ones. Histopathological changes were greatly reduced in MSPTT, confirming its promising role in restricting L. monocytogenes translocation to different organs. Therefore, our results suggest the use of MSPTT as an alternative to antibiotics, thereby conferring protection for rabbits against L. monocytogenes infection.