Miracle-dz/UniFAR-FTUs huggingface dataset:
A 3D thermal conductivity prediction method for deep strata based on temperature field estimation

Accurate predictions of Earths interior thermal conductivity are essential for interpreting the mechanisms involved in geothermal systems and delineating geothermal resource targets. Existing thermal conductivity prediction methods, which typically involve measurements of rock samples and predictions based on geophysical well logging, cannot accurately predict regional thermal conductivity distributions. We presented a 3D thermal conductivity prediction based on temperature field estimation. First, the finite element method is used for temperature forward modeling. Subsequently, the inexact Gauss-Newton method was implemented in the prediction algorithm. Synthetic studies showed that the method can recover the true model well. The subsurface temperature distribution of the Xiongan New Area was predicted using the coefficient correction method of the optimal temperature. After that, we obtained the 3D distribution of thermal conductivity of deep formation in the Xiongan New Area with the predicted temperature field. The distribution of terrestrial heat flow is also estimated. In addition, the law of thermal accumulation of strata at different depths was analyzed; and the internal relation among resistivity, temperature, and thermal conductivity was studied. Thus, the 3D thermal conductivity prediction method provides the theoretical basis for interpreting mechanisms for the origin of geothermal systems and heat accumulation patterns. It could have significant utility for the analysis of geothermal fields and the sustainable development and utilization of geothermal resources.
WEBSITE SECURITY TEST AT THE UNIVERSITY OF MATARAM USING VULNERABILITY ASSESSMENT

Perkembangan internet dan teknologi telah memberikan dampak yang besar terhadap berbagai kebutuhan manusia. Menurut data dari Internet Live Stats ada lebih dari 5 miliar pengguna internet saat ini. Dengan banyaknya pengguna internet dan website, maka akan semakin banyak juga pihak yang menyalahgunakan internet dan website dalam tindak pidana. Sebuah website membutuhkan tingkat keamanan yang tinggi untuk mencegah penipuan dan manipulasi yang dilakukan oleh pihak yang tidak bertanggung jawab. Dalam melindungi informasi yang terdapat pada website, kerentanan website menjadi perhatian penting agar tidak mudah dieksploitasi. Langkah-langkah yang dapat dilakukan adalah dengan memulai dengan menerapkan metode penetration testing untuk mengetahui kerentanan pada website yang dijadikan objek penelitian oleh penulis sehingga hasil dari proses pengujian dapat menjadi gambaran kondisi dan kerentanan apa saja yang ada. pada situs web target atau objek situs web. Pada penelitian ini website yang menjadi sasaran adalah unram.ac. id milik Universitas Mataram yang digunakan untuk operasional perusahaan dengan menggunakan beberapa tools pengujian yaitu Hosted Scan dalam pencarian ulang dan pengujian keamanan website sebelumnya. Pada penelitian ini ditemukan beberapa kerentanan pada level tinggi, sedang, dan rendah pada website target, sehingga dilakukan pengujian dan perbaikan pada website sehingga dapat meningkatkan keamanan layanan website yang akan digunakan untuk perusahaan. operasi
Effect of Annealing Times on the Structural and Optical Properties of PbO Thin Films Prepared by D.C Sputtering

In this work, lead oxide (PbO) thin films were deposited using D.C. sputtering method on a surface of glass substrates and then thermally annealed at a temperature of 473K with annealing times of (1,2 and 3) hours. The structural, morphological, and optical properties of films were determined using X-ray diffraction (XRD), atomic force microscopy (AFM), FT-IR, and UV-Visible spectroscopy. The structure studies confirmed that PbO films are polycrystalline structures in an orthorhombic phase with average grain size (24.51, 29.64, 46.49, 16) nm with increasing annealing time. From AFM, the roughness of the film surface (3.26, 1.76, 1.61, 1.79) nm as the film annealing time increases. The optical band gap values of the PbO thin films are (3.9, 2.8, 3.7, 2.4) eV as the annealing time increases.
SURVEY ON AWARENESS ABOUT ORTHODONTIC TREATMENT IN GENERAL POPULATION OF NAGPUR DISTRICT.

Dr Atram Harish 1 , Dr Jakati Sanjeev V 1 , Dr Namrata Khetal 2 , Dr PV Hazarey 3 , Dr Mrunal Aley 4 , Dr Achint Chachada 4 and Dr Mugdha Mankar 1 . 1. MDS Orthodontics, Assistant Professor Orthodontics & Dentofacial Orthopaedics, Swargiya Dadasaheb Kalmegh Smruti Dental College & Hospital Nagpur Maharashtra India. 2. BDS, Swargiya Dadasaheb Kalmegh Smruti Dental College & Hospital Nagpur Maharashtra India. 3. MDS Orthodontics Professor & HOD ,Orthodontics & Dentofacial Orthopaedics, Swargiya Dadasaheb Kalmegh Smruti Dental College & Hospital Nagpur Maharashtra India. 4. MDS Orthodontics Associate Professor, Orthodontics & Dentofacial Orthopaedics, Swargiya Dadasaheb Kalmegh Smruti Dental College & Hospital Nagpur Maharashtra India . Manuscript Info Abstract . Manuscript History
Optimal Distributed Coordinated Reinforcement Learning for Secondary Voltage Control in Time-Delayed Microgrid

This article proposes an optimal distributed secondary voltage control method based on distributed coordinated reinforcement learning (DCRL) algorithm in the time-delayed microgrid. First, a distributed secondary voltage control protocol through a sparse communication network is designed using consensus-based algorithm and Lyapunov–Krasovskii theory. Then, by combining the consensus control method with reinforcement learning together, a novel DCRL algorithm is utilized to dynamically adjust the voltage controller gains. Since the DCRL method is an online intelligent algorithm, it can adaptively improve the voltage control performance in the presence of various external disturbances encountered in microgrid secondary control. The effectiveness of the proposed method is verified through simulations under different scenarios on a four inverter-based microgrid test system. Simulation results indicate that our method shows superior dynamic voltage regulation response over traditional methods.
Crystal structure of the GDSL family esterase EstL5 in complex with PMSF reveals a branch channel of the active site pocket

Esterases/lipases from the GDSL family have potential applications in the hydrolysis and synthesis of important esters of pharmaceutical, food, and biotechnical interests. However, the structural and functional understanding of GDSL enzymes is still limited. Here, we report the crystal structure of the GDSL family esterase EstL5 complexed with PMSF at 2.34 Å resolution. Intriguingly, the PMSF binding site is not located at the active site pocket but is situated in a surface cavity. At the active site, we note that there is a trapped crystallization solvent 1,6-hexanediol, which mimics the bound ester chain, allowing for further definition of the active site pocket of EstL5. The most striking structural feature of EstL5 is the presence of a unique channel, which extends approximately 18.9 Å, with a bottleneck radius of 6.8 Å, connecting the active-site pocket and the surface cavity. Replacement of Ser205 with the bulk aromatic residue Trp or Phe could partially block the channel at one end and perturb its access. Reduced enzymatic activity is found in the EstL5 S205W and EstL5 S205F mutants, suggesting the functional relevance of the channel to enzyme catalysis. Our study provides valuable information regarding the properties of the GDSL-family enzymes for designing more efficient and robust biocatalysts.
Dynamic Response of Beam on a New Non-Uniform Dynamic Foundation Subjected to a Moving Vehicle Using Finite Element Method

The purpose of paper analyzes influence of foundation mass on dynamic response of beam on non-uniform foundation subjected to a moving vehicle. This foundation model includes non-uniform linear elastic springs, shear layer, viscous damping and special consideration of the influence of a characteristic parameter of foundation mass. The moving vehicle is assumed to be consisted of two nodal masses that are connected by means of a spring-damper components. The equation of motion for the beam-vehicle-foundation interaction element is derived by means of dynamic balance principle. After by assembling the stiffness, damping and mass matrices, and vectors of nodal loads of all elements based on finite element method, the governing equations of motion for the integrated system are obtained and solved by step-by-step integration method procedure. The accuracy of the algorithm is verified by comparing the numerical results with the other numerical results in the literature. Also, the effects of characteristic parameter of foundation mass on dynamic analysis of beamvehicles interaction are investigated detail. The results show that the influence of foundation mass has effects significantly on dynamic response of beam-vehicle interaction and more increasing dynamic response than others without influence of foundation mass. Keywords-Foundation mass; moving vehicle; non-uniform foundation; dynamic analysis of beam-vehicle interaction
Lower Badenian benthic foraminifera from Glavnica gornja locality

obilježene su izrazito transgresivnim kontaktom, bogatim fosilnim sadržajem i osobito velikom facijesnom raznolikoscu (KOCHANSKY, 1957). Profil Glavnica Gornja je smjesten na jugoistocnim padinama Medvednice, uzduž uske seoske ceste koja vodi prema istoimenom naselju, u duljini oko 120 m, visine oko 2 m. , i na vise mjesta je u potpunosti prekriven vegetacijom. Masivni sivkasto zelenkasti lapori kontinuirano prelaze u glinovite lapore, a mjestimicno se uzduž profila mogu uociti i glinoviti slojevi debljine do 1 m. Detaljna taksonomska i statisticka analiza zajednica bentickih foraminifera je napravljena na standardiziranim uzorcima u svrhu utvrđivanja starosti naslaga i interpretacije paleookolisa. Donjobadenska starost utvrđena je na temelju nalaza provodnih vrsta Uvigerina grilli SCHMID, Uvigerina pygmoides PAPP &TURNOVSKI i Bolivina viennensis MARKS, kao i brojne zastupljenosti nodosarida i stilstomelida od kojih su najznacajnije vrste Dentalina acuta D'ORBIGNY, Pseudonodosaria brevis D'ORBIGNY, Lenticulina vortex (FICHTELL & MOLL), Vaginulinopsis pedum (D'ORBIGNY), Planularia dentata (KARRER) te Planularia lanceolata (D'ORBIGNY). Vrlo raznolika zajednica bentickih foraminifera (24- 30vrsta) obitavala je u dubokovodnom okolisu vanjskog selfa do gornjeg batijala. Dominiraju tipicne dubokovodne infaunalne vrste Bolivina dilatata REUSS, Bolivina viennensis MARKS, ali također i epifaunalne vrste Cibicidoides ungerianus (D'ORBIGNY) i Cibicidoides pseudoungerianus (D'ORBIGNY). Ceste su i vrste Lenticulina inornata (D'ORBIGNY) i Angulogerina angulosa (WILLIAMSON). Na morskom dnu su vladali srednje oksicni uvjeti, s nesto nižim vrijednostima u sredisnjem dijelu profila gdje se gotovo približavaju nisko oksicnim vrijednostima, sto ukazuje na povecani donos organskih tvari. Stresnije ekoloske uvjete u sredisnjem dijelu profila također potvrđuje i porast dominacije unutar zajednice bentickih foraminifera kao i znatan porast udjela disoksicnih i infaunalnih oblika.
Investigation of polarization reversal and analysis of switching current data in KTP single crystals

ABSTRACT We have studied the polarization reversal process and analyzed the switching currents in KTiOPO4 single crystals with intermediate potassium content. The activation field dependence of the switching time has been revealed. Two stages of the polarization reversal have been distinguished during analysis of the switching current data. The first stage with smooth current corresponds to β(2D)-process fitted by Kolmogorov-Avrami formula. The second stage with spikes in the switching current caused by intensive domain merging was analyzed by a modified Korcak method. The obtained value of the Hurst exponent indicated the weak persistence of the switching process with long-time correlation.
Evaluation of Homogentisic Acid, a Prospective Antibacterial Agent Highlighted by the Suitability of Nitisinone in Alkaptonuria 2 (SONIA 2) Clinical Trial

Despite urgent warnings about the spread of multidrug-resistant bacteria, the antibiotic development pipeline has remained sparsely populated. Naturally occurring antibacterial compounds may provide novel chemical starting points for antibiotic development programs and should be actively sought out. Evaluation of homogentisic acid (HGA), an intermediate in the tyrosine degradation pathway, showed that the compound had innate activity against Gram-positive and Gram-negative bacteria, which was lost following conversion into the degradation product benzoquinone acetic acid (BQA). Anti-staphylococcal activity of HGA can be attributed to effects on bacterial membranes. Despite an absence of haemolytic activity, the compound was cytotoxic to human HepG2 cells. We conclude that the antibacterial activity and in vitro safety profile of HGA render it more suitable for use as a topical agent or for inclusion in a small-molecule medicinal chemistry program.
Effects of Sihuang Zhili Granules on the Diarrhea Symptoms, Immunity, and Antioxidant Capacity of Poultry Challenged with Lipopolysaccharide (LPS)

A growing interest has been focused on Chinese herbs as alternatives to antimicrobial growth promoters, which are characterized by non-toxic side effects and drug resistance. The purpose of this study was to evaluate the effects of the Sihuang Zhili granule (abbreviated as Sihuang) on diarrhea, immunity, and antioxidation in poultry. Thirty male Leghorn chickens, aged 21 days, were randomly assigned to one of three groups with ten animals each. The control group (CON) received intraperitoneal saline injections, while the LPS-challenged group (LPS) and Sihuang intervention group (SH) received intraperitoneal injections of LPS (0.5 mg/kg of BW) and Sihuang (5 g/kg) at d 31, d 33, d 35, respectively. The control and LPS groups were fed a basal diet, while the SH group was fed a diet supplemented with Sihuang from d 21 to d 35. Analysis of the diarrhea index showed that the addition of Sihuang inhibited the increase in the diarrhea grade and the fecal water content caused by LPS, effectively alleviating poultry diarrhea symptoms. The results of the immune and antioxidant indexes showed that Sihuang significantly reduced the contents of the pro-inflammatory factors TNF- α and IL-1 β, as well as the oxidative stress markers ROS and MDA. Conversely, it increased the contents of the anti-inflammatory factors IL-4 and IL-10, along with the activities of antioxidant enzymes GSH-Px and CAT, thereby enhancing the immune and antioxidant abilities of chickens. Furthermore, Sihuang protected the chicken’s ileum, liver, and immune organs from LPS invasion and maintained their normal development. In conclusion, this study confirmed the antidiarrheal effect of Sihuang in poultry farming and demonstrated its ability to improve poultry immunity and antioxidant capacity by modulating antioxidant enzyme activity and inflammatory cytokine levels.
Chaos, Instability and a Stranger Metal

An upper bound on Lyapunov exponent of a thermal many body quantum system has been conjectured recently. In this work, we attempt to achieve a physical understanding of what prevents a system from violating this bound. We suggest the answer is that super-maximal chaos leads to instability. Our suggestion is based on findings in a SYK lattice model, with a tuneable parameter, which the Lyapunov spectrum depends upon. In the stable regime of this parameter, along with incoherent metallic phase, the system exhibits another novel phase, where transport is controlled neither by quasi-particles nor by diffusion. At the phase transition diffusion coefficient, butterfly velocity and Thouless time diverges.
Foliar applications of ascorbic and citric acids with soil application of humic acid for improve growth, yield and fruit quality of grape

: The purpose of this study is to see how foliar applications of ascorbic acid and citric acid, as well as soil applications of humic acid, affect Superior seedless grapevine growth, yield and fruit quality in both seasons of 2021 and 2022. This research was carried out at a private orchard in Al-Khatahtbah - Sadat, Menoufia Governorate, Egypt. The vineyard was planted at distance of 2 x 3 meters apart under drip irrigation and trellised using the Spanish Parron technique, which resulted in 12 spurs with ten eyes each. The treatments were as follows: control (untreated vines), foliar ascorbic acid and citric acid at concentrations 1200 and 1300 PPm for each and soil humic acid addition at concentrations 1.5 and 2 kg/fed. and varied combinations of them. All treatments significantly improved characteristics of vegetative growth such as shoot length, leaf development, leaf area, number of leaves/shoot, fresh weight and dry weight, total chlorophyll content, as well as cluster characteristics, berry physical parameters, berry biochemical characteristics and yield. The results cleared that increasing rates of ascorbic acid, citric acid and humic acid followed gradually by an increase in all studied parameters.
Numerical Investigation of Turbulent Combustion Flow in Industrial Combustor with Flamelet Approach

In this paper, an industrial gas-turbine combustor was numerically investigated by applying large-eddy simulation for turbulent model and 2-scalar flamelet approach for combustion model. In the combustion model, the structures of premixed and non-premixed flame are expressed by conservative scalar and levelset function respectively. These two concepts are coupled for partial premixed combustion field. Flow field properties inside the flame (temperature, density, laminar flame speed) are determined by “flamelet data”. The flamelet data is mainly divided in “premixed-like flamelet data” and “diffusion-like flamelet data” in this study. The premixed-like flamelet data is based on chemical equilibrium assumption and is evaluated by 0-dimensional chemical reaction calculation. On the other hand, the diffusion-like flamelet data is based on laminar flamelet assumption and is evaluated by 1-dimensional counter flow combustion calculation. In this study, for the diffusion-like combustion field in the industrial combustor, diffusion-like flamelet data was newly applied. The predicted gas temperature showed a little higher value than the temperature calculated by using the premixed-like flamelet data. However, the predicted temperatures underestimated measured one. Therefore, in this case, it was cleared that difference of flamelet data is insignificant for improving analysis accuracy.
Caspase-8 and Tyrosine Kinases: A Dangerous Liaison in Cancer

Simple Summary Caspase-8 is a protease mediating the activation of the extrinsic apoptotic process that leads to programmed cellular death. Evasion of apoptosis is one of the key hallmarks of cancer and Caspase-8 has commonly been associated with an antitumor protective role. However, observations that several solid tumor types inconsistently display aberrantly high levels of Caspase-8 has fueled studies that challenge this dogma. In this review, we summarize the current state of the art on how tumors benefit from high levels of Caspase-8 expression. In addition, we discuss the mechanisms through which tumors are able to alter the function of Caspase-8 and turn a protective protein into an ally. Specifically, we focus on the role played by tyrosine kinases in inhibiting the enzymatic role of Caspase-8 and remodulating Caspase-8 function in cancer through tyrosine phosphorylation. Abstract Caspase-8 is a cysteine-aspartic acid protease that has been identified as an initiator caspase that plays an essential role in the extrinsic apoptotic pathway. Evasion of apoptosis is a hallmark of cancer and Caspase-8 expression is silenced in some tumors, consistent with its central role in apoptosis. However, in the past years, several studies reported an increased expression of Caspase-8 levels in many tumors and consistently identified novel “non-canonical” non-apoptotic functions of Caspase-8 that overall promote cancer progression and sustain therapy resistance. These reports point to the ability of cancer cells to rewire Caspase-8 function in cancer and raise the question of which are the signaling pathways aberrantly activated in cancer that may contribute to the hijack of Caspase-8 activity. In this regard, tyrosine kinases are among the first oncogenes ever identified and genomic, transcriptomic and proteomic studies indeed show that they represent a class of signaling molecules constitutively activated in most of the tumors. Here, we aim to review and discuss the role of Caspase-8 in cancer and its interplay with Src and other tyrosine kinases.
Effect of space charge on the negative oxygen flux during reactive sputtering

Negative ions often play a distinctive role in the phase formation during reactive sputter deposition. The path of these high energetic ions is often assumed to be straight. In this paper, it is shown that in the context of reactive magnetron sputtering space charge effects are decisive for the energetic negative ion trajectories. To investigate the effect of space charge spreading, reactive magnetron sputter experiments were performed in compound mode with target materials that are expected to have a high secondary ion emission yield (MgO and CeO2). By the combination of energy flux measurements, and simulations, a quantitative value for the negative oxygen ion yield can be derived.
Design of highly sensitive multichannel bimetallic photonic crystal fiber biosensor

Abstract. A design of a highly sensitive multichannel biosensor based on photonic crystal fiber is proposed and analyzed. The suggested design has a silver layer as a plasmonic material coated by a gold layer to protect silver oxidation. The reported sensor is based on detection using the quasi transverse electric (TE) and quasi transverse magnetic (TM) modes, which offers the possibility of multichannel/multianalyte sensing. The numerical results are obtained using a finite element method with perfect matched layer boundary conditions. The sensor geometrical parameters are optimized to achieve high sensitivity for the two polarized modes. High-refractive index sensitivity of about 4750 nm/RIU (refractive index unit) and 4300 nm/RIU with corresponding resolutions of 2.1×10−5 RIU, and 2.33×10−5 RIU can be obtained according to the quasi TM and quasi TE modes of the proposed sensor, respectively. Further, the reported design can be used as a self-calibration biosensor within an unknown analyte refractive index ranging from 1.33 to 1.35 with high linearity and high accuracy. Moreover, the suggested biosensor has advantages in terms of compactness and better integration of microfluidics setup, waveguide, and metallic layers into a single structure.