Miracle-dz/UniFAR-FTUs huggingface dataset:
Monounsaturated Fatty Acids in Obesity-Related Inflammation

Obesity is an important aspect of the metabolic syndrome and is often associated with chronic inflammation. In this context, inflammation of organs participating in energy homeostasis (such as liver, adipose tissue, muscle and pancreas) leads to the recruitment and activation of macrophages, which secrete pro-inflammatory cytokines. Interleukin-1β secretion, sustained C-reactive protein plasma levels and activation of the NLRP3 inflammasome characterize this inflammation. The Stearoyl-CoA desaturase-1 (SCD1) enzyme is a central regulator of lipid metabolism and fat storage. This enzyme catalyzes the generation of monounsaturated fatty acids (MUFAs)—major components of triglycerides stored in lipid droplets—from saturated fatty acid (SFA) substrates. In this review, we describe the molecular effects of specific classes of fatty acids (saturated and unsaturated) to better understand the impact of different diets (Western versus Mediterranean) on inflammation in a metabolic context. Given the beneficial effects of a MUFA-rich Mediterranean diet, we also present the most recent data on the role of SCD1 activity in the modulation of SFA-induced chronic inflammation.
Electrochemical Oxidation of Ti15Mo Alloy—The Impact of Anodization Parameters on Surface Morphology of Nanostructured Oxide Layers

It is well-known that the structure and composition of the material plays an important role in the processes occurring at the surface. In this paper, a surface morphology of nanostructured oxide layers electrochemically grown on Ti15Mo, tuned by applying different anodization parameters, was investigated in detail. The one-step anodization of Ti15Mo alloy was performed at room temperature in an ethylene glycol-based electrolyte containing 0.11 M NH4F and 1.11 M H2O. Different anodization times (ranging from 5 to 60 min) and applied potentials (40–100 V) were tested, and the surface morphology, elemental content, and crystalline structure were monitored by scanning electron microscopy (SEM), energy dispersive X-ray spectrometry (EDS), and X-ray diffractometry (XRD), respectively. The results showed that contrary to the multistep anodization of titanium foil, the surface morphology of anodic oxide obtained via the one-step process contains the nanoporous outer layer covering the nanotubular structure. What is more, the pore diameter (Dp) and interpore distance (Dint) of such layers exhibit different trends than those observed for anodization of pure titanium. In particular, at a certain potential range, a decrease in both Dp and Dint with increasing potential was observed. However, independently on the used anodization conditions, the elemental content of oxide layers remained similar, showing the amount of molybdenum at c.a. 15 wt. %. Finally, the amorphous nature of as-anodized layers was confirmed, and their optical band-gap was determined from the diffuse reflectance UV–Vis spectra. It was found that Eg is tunable to some extent by changing the anodizing potential. However, further thermal treatment in air at 400 °C resulted in the anatase phase formation that was accompanied by a significant Eg reduction. Therefore, we believe that the presented results will greatly contribute to the understanding of anodic formation of nanostructured functional oxide layers with tunable properties that can be applied in various fields.
Analysis of the Efficacy of Different Thought Suppression Strategies

Some researches have demonstrated that when one wants to suppress a thought, it is paradoxically the first thing that comes to mind. However, subsequent studies on this topic have pointed out that successful thought suppression depends on the specific strategy employed to deal with the unwanted thought. The present study examined the impact of different thought suppression instructions on the frequency and appraisals of memories about the March 11 attacks that took place in 2004 in Madrid. Thus, 120 undergraduates were randomly allocated to the following experimental conditions: thought suppression, thought suppression with focused distraction, thought suppression confronting a reminder, and monitor-only. Data analysis showed an absence of paradoxical effects, that is, neither immediate nor delayed frequency increases of the target thought. Furthermore, those participants instructed to use focused distraction reported less intrusions than those from the control condition at short and long-term. Finally, the results are discussed in relation to previous studies on thought control.
Aerodynamic Load Control through Blowing

Aircraft are subject to extreme loads during gust encounters. Amelioration of these loads will allow for reduced structural weight and therefore greater efficiency. In this paper, two versions of blowing jet from suction surface, normal and upstream, are studied under steady state conditions to illustrate the effectiveness of these devices at mitigating extreme lift. Force, pressure and Particle Image Velocimetry measurements were performed at a Reynolds number of 660,000 for a NACA 0012 airfoil. A range of volumetric flow rate coefficients, below CQ = 0.44%, for a range of angles of attack 0° ≤ α ≤ 20°, are studied for five chordwise locations. It was observed that normal blowing at xJ/c = 0.95 induces a change in lift of ΔCL = -0.15 for the maximum momentum coefficient. Locations further forward produce a negligible change in lift coefficient. Whereas, upstream blowing was capable of reducing lift at all chordwise locations studied by up to ΔCL = -0.33. Upstream blowing encourages the shear layer to deflect upwards and inciting a greater adverse pressure gradient on the upper surface. Locations near the trailing edge are preferable for low angles of attack, as greater lift mitigation is obtained. Lift reduction can be augmented for higher angles of attack, with leading edge locations. As expected, increasing momentum coefficient increases the magnitude of the change in lift for all cases studied.
Prognostic Factors in Male Breast Cancer: A Single Centre Experience.

OBJECTIVE To determine the prognostic factors by assessing the clinicopathological characteristics of the male patients with breast cancer (MBC). STUDY DESIGN Observational study. PLACE AND DURATION OF STUDY Department of Internal Medicine, HSU Dr. Abdurrahman Yurtaslan Oncology, Training and Research Hospital, Turkey, between January 2010 and November 2018. METHODOLOGY Data of patients with MBC were evaluated. Age ≥18 years, diagnosis of breast carcinoma, and male gender were the inclusion criteria of the study. Patients were excluded from the study, if their data were incomplete. Ki-67, the status of estrogen receptor (ER), progesterone receptor (PR), and HER2 receptor were obtained from the hospital records. Kaplan-Meier method was performed for survival analysis. Cox regression analysis was used to determine independent prognostic factors of overall survivall (OS). RESULTS Out of the 73 patients included in the study, 37 of them aged under 65, while 36 of them aged 65 or over. ER positivity was 94.5%, while PR positivity was 87.7%, and HER2 positivity was 13.7%. It was found that as a result of the univariate analysis, the 5-year OS of the elderly group (≥65 years) was lower compared to the younger group (<65 years, 74.2% vs. 93.3%, p=0.022). Age, tumor grade, and T stage were included in the multivariate Cox regression analysis and only advanced age was found to be an independent poor prognostic factor (HR: 3.068, 95% CI: 1.013-9.293, p=0.047). CONCLUSION Advanced age might be an independent poor prognostic factor for patients with MBC. Key Words: Breast cancer, Elderly, Male, Prognosis.
ProFuzzer: On-the-fly Input Type Probing for Better Zero-Day Vulnerability Discovery

Existing mutation based fuzzers tend to randomly mutate the input of a program without understanding its underlying syntax and semantics. In this paper, we propose a novel on-the-fly probing technique (called ProFuzzer) that automatically recovers and understands input fields of critical importance to vulnerability discovery during a fuzzing process and intelligently adapts the mutation strategy to enhance the chance of hitting zero-day targets. Since such probing is transparently piggybacked to the regular fuzzing, no prior knowledge of the input specification is needed. During fuzzing, individual bytes are first mutated and their fuzzing results are automatically analyzed to link those related together and identify the type for the field connecting them; these bytes are further mutated together following type-specific strategies, which substantially prunes the search space. We define the probe types generally across all applications, thereby making our technique application agnostic. Our experiments on standard benchmarks and real-world applications show that ProFuzzer substantially outperforms AFL and its optimized version AFLFast, as well as other state-of-art fuzzers including VUzzer, Driller and QSYM. Within two months, it exposed 42 zero-days in 10 intensively tested programs, generating 30 CVEs.
ON THE ORIGIN OF X-RAY SPECTRA IN LUMINOUS BLAZARS

Gamma-ray luminosities of some quasar-associated blazars imply jet powers reaching values comparable to the accretion power even if assuming very strong Doppler boosting and very high efficiency of gamma-ray production. With much lower radiative efficiencies of protons than of electrons, and the recent reports of very strong coupling of electrons with shock-heated protons indicated by particle-in-cell simulations, the leptonic models seem to be strongly favored over the hadronic ones. However, the electron–proton coupling combined with the external-radiation-Compton (ERC) models of gamma-ray production in leptonic models predict extremely hard X-ray spectra, with energy indices αx ∼ 0. This is inconsistent with the observed 2–10 keV slopes of blazars, which cluster around αx ∼ 0.6. This problem can be resolved by assuming that electrons can be efficiently cooled down radiatively to non-relativistic energies, or that blazar spectra are entirely dominated by the synchrotron self-Compton (SSC) component up to at least 10 keV. Here, we show that the required cooling can be sufficiently efficient only at distances r < 0.03 pc. SSC spectra, on the other hand, can be produced roughly co-spatially with the observed synchrotron and ERC components, which are most likely located roughly at a parsec scale. We show that the dominant SSC component can also be produced much further than the dominant synchrotron and ERC components, at distances of ≳ 10 pc. Hence, depending on the spatial distribution of the energy dissipation along the jet, one may expect to see γ-ray/optical events with either correlated or uncorrelated X-rays. In all cases the number of e+e− pairs per proton is predicted to be very low. The direct verification of the proposed SSC scenario, and particularly the question of the co-spatiality of the SSC component with other spectral components, requires sensitive observations in the hard X-ray band. This is now possible with the deployment of the NuSTAR satellite, providing the required sensitivity to monitor the details of the hard X-ray spectra of blazars in the range where the ERC component is predicted to start dominating over the SSC component.
Influence of the Botanical and Geographical Origin on the Mineral Composition of Honey

Elemental composition was analysed to determine the effect of the botanical and geographical origin on the mineral content in black locust (Robinia pseudoacacia L.), chestnut (Castanea sativa Mill.), and lime (Tilia spp.) honey. Th e study included 174 samples from three different geographical and climatic regions in Croatia. A total of 15 elements were analysed using inductively coupled plasma mass spectrometry (ICP-MS). Th e highest total mineral content was determined in chestnut honey samples, followed by the lime and black locust honey samples, in descending order of presence: K, Ca, Na, Mg, Mn and Fe. A good potential of marking the botanical origin was confirmed on the basis of increased contents of Mn and Sr in chestnut honey. Increased concentrations of Pb and Zn determined in honey samples from the Pannonian Region showed to be a good basis for demarcation of the geographical origin. The content of some heavy metals in honey were low (Median: Cd 0.005 mg/kg ; Pb 0.015 mg/kg ; Ni 0.083 mg/kg ; Zn 1.362 mg/kg ; with no harmful health eff ects).
A MEDIATOR OF STUDENTS' ATTITUDES AND ACHIEVEMENT

Aiken's Mathematics Attitude Scale (MAS) was administered to 70 elementary school teachers; achievement and attitude data were collected from seven randomly selected students of each teacher. Change in student attitudes and achievement during the school year were considered in relation tu teachers' scores on the two subscales of the MAS; these subscales are Enjoyment of Mathematics and Value of Mathematics. Results indicated that students' attitudes and achievement were unrelated to their teachers' scores on the value subscale. However, there was a significant positive relationship between teachers' enioyment of mathematics and students' achievement. (SD) *********************************************************************** Documents acquired by ERIC include many informal unpublished * materials not available from other sources. ERIC makes every effort * * to obtain the best copy available. Nevertheless, items of marginal * * reproducibility are often encountered and this affects the quality * * of the microfiche and hardcopy reproductions ERIC makes available * via the ERIC Document Reproduction Service (EDRS). EDRS is not * responsible for the quality of the original document. Reproductions * * supplied by EDRS are the best that can be made from the original. ***********************************************************************
Efficacy of artemisinin–lumefantrine for treatment of uncomplicated malaria after more than a decade of its use in Kenya

Abstract Background The resistance of Plasmodium falciparum to antimalarial drugs remains a major impairment in the treatment and eradication of malaria globally. Following the introduction of artemisinin-based combination therapy (ACT), there have been reports of delayed parasite clearance. In Kenya, artemether–lumefantrine (AL) is the recommended first-line treatment of uncomplicated malaria. This study sought to assess the efficacy of AL after a decade of use as the preferred method of managing malarial infections in Kenya. We assessed clinical and parasitological responses of children under 5 years between May and November 2015 in Chulaimbo sub-County, Kisumu, Kenya. Patients aged between 6 and 60 months with uncomplicated P. falciparum mono-infection, confirmed through microscopy, were enrolled in the study. The patients were admitted at the facility for 3 days, treated with a standard dose of AL, and then put under observation for the next 28 days for the assessment of clinical and parasitological responses. Of the 90 patients enrolled, 14 were lost to follow-up while 76 were followed through to the end of the study period. Seventy-five patients (98.7%) cleared the parasitaemia within a period of 48 h while one patient (1.3%) cleared on day 3. There was 100% adequate clinical and parasitological response. All the patients cleared the parasites on day 3 and there were no re-infections observed during the stated follow-up period. This study, therefore, concludes that AL is highly efficacious in clearing P. falciparum parasites in children aged ≥6 and ≤60 months. The study, however, underscores the need for continued monitoring of the drug to forestall both gradual ineffectiveness and possible resistance to the drug in all target users.
Evidence of vascular endothelial dysfunction in Wooden Breast disorder in chickens: Insights through gene expression analysis, ultra-structural evaluation and supervised machine learning methods

Several gene expression studies have been previously conducted to characterize molecular basis of Wooden Breast myopathy in commercial broiler chickens. These studies have generally used a limited sample size and relied on a binary disease outcome (unaffected or affected by Wooden Breast), which are appropriate for an initial investigation. However, to identify biomarkers of disease severity and development, it is necessary to use a large number of samples with a varying degree of disease severity. Therefore, in this study, we assayed a relatively large number of samples (n = 96) harvested from the pectoralis major muscle of unaffected (U), partially affected (P) and markedly affected (A) chickens. Gene expression analysis was conducted using the nCounter MAX Analysis System and data were analyzed using four different supervised machine-learning methods, including support vector machines (SVM), random forests (RF), elastic net logistic regression (ENET) and Lasso logistic regression (LASSO). The SVM method achieved the highest prediction accuracy for both three-class (U, P and A) and two-class (U and P+A) classifications with 94% prediction accuracy for two-class classification and 85% for three-class classification. The results also identified biomarkers of Wooden Breast severity and development. Additionally, gene expression analysis and ultrastructural evaluations provided evidence of vascular endothelial cell dysfunction in the early pathogenesis of Wooden Breast.
A Novel Ebola Virus VP40 Matrix Protein-Based Screening for Identification of Novel Candidate Medical Countermeasures

Filoviruses, such as Ebola virus and Marburg virus, are of significant human health concern. From 2013 to 2016, Ebola virus caused 11,323 fatalities in Western Africa. Since 2018, two Ebola virus disease outbreaks in the Democratic Republic of the Congo resulted in 2354 fatalities. Although there is progress in medical countermeasure (MCM) development (in particular, vaccines and antibody-based therapeutics), the need for efficacious small-molecule therapeutics remains unmet. Here we describe a novel high-throughput screening assay to identify inhibitors of Ebola virus VP40 matrix protein association with viral particle assembly sites on the interior of the host cell plasma membrane. Using this assay, we screened nearly 3000 small molecules and identified several molecules with the desired inhibitory properties. In secondary assays, one identified compound, sangivamycin, inhibited not only Ebola viral infectivity but also that of other viruses. This finding indicates that it is possible for this new VP40-based screening method to identify highly potent MCMs against Ebola virus and its relatives.
Dissociating Representations of Time and Number in Reinforcement-Rate Learning by Deletion of the GluA1 AMPA Receptor Subunit in Mice

Theories of learning differ in whether they assume that learning reflects the strength of an association between memories or symbolic encoding of the statistical properties of events. We provide novel evidence for symbolic encoding of informational variables by demonstrating that sensitivity to time and number in learning is dissociable. Whereas responding in normal mice was dependent on reinforcement rate, responding in mice that lacked the GluA1 AMPA receptor subunit was insensitive to reinforcement rate and, instead, dependent on the number of times a cue had been paired with reinforcement. This suggests that GluA1 is necessary for weighting numeric information by temporal information in order to calculate reinforcement rate. Sample sizes per genotype varied between seven and 23 across six experiments and consisted of both male and female mice. The results provide evidence for explicit encoding of variables by animals rather than implicit encoding via variations in associative strength.
Changes in sympathetic nervous system activity after renal denervation: results from the randomised Oslo RDN study

Abstract Purpose Sympathetic nervous system (SNS) over-activity is associated with essential hypertension. Renal sympathetic denervation (RDN) possibly lowers office- and ambulatory blood pressure (BP) in patients with treatment-resistant hypertension (TRH). We aimed to assess the effect of RDN compared to drug adjustment on SNS activity among patients with TRH by measuring plasma catecholamines and heart rate variability (HRV) during stress tests. Materials and methods Patients with TRH were randomised to RDN (n = 9) or Drug Adjustment (DA) (n = 10). We measured continuous HRV and beat-to-beat-BP using FinaPres® and obtained plasma catecholamines during standardised orthostatic- and cold-pressor stress tests (CPT) before- and six months after randomisation. Results CPT revealed no differences between groups at baseline in peak adrenaline concentration (69.3 pg/mL in the DA group vs. 70.0 pg/mL in the RDN group, p = 0.38) or adrenaline reactivity (Δ23.1 pg/mL in the DA group vs. Δ29.3 pg/mL in the RDN group, p = 0.40). After six months, adrenaline concentrations were statistically different between groups after one minute (66.9 pg/mL in the DA group vs. 55.3 pg/mL in the RDN group, p = 0.03), and six minutes (62.4 pg/mL in the DA group vs. 50.1 pg/mL in the RDN group, p = 0.03). There was a tendency of reduction in adrenaline reactivity after six months in the RDN group (Δ26.3 pg/mL at baseline vs. Δ12.8 pg/ml after six months, p = 0.08), while it increased in the DA group (Δ13.6 pg/mL at baseline vs. Δ19.9 pg/mL after six months, p = 0.53). We also found a difference in the Low Frequency band at baseline following the CPT (667µs2 in the DA group vs. 1628µs2 in the RDN group, p = 0.03) with a clear tendency of reduction in the RDN group to 743µs2 after six months (p = 0.07), compared to no change in the DA group (1052µs2, p = 0.39). Conclusion Our data suggest that RDN reduces SNS activity after six months. This finding warrants investigation in a larger study. Clinical Trial Number registered at www.clinicaltrials. gov: NCT01673516
The Two Greatest. Great Recession vs. Great Moderation

The collapse of the global economy in 2008, following the outbreak of the financial crisis, and the ensuing economic developments of the so-called Great Recession (GR) led many economists to suggest that the Great Moderation (GM) had, indeed, come to an end. This paper offers evidence that the decrease in output volatility still remains in force despite the GR and would do so even if the GR continues to extended horizons. This finding has important implications not only for academics, concerning the implementation of theoretical and empirical techniques, but also for policymakers, regarding the understanding of the pattern of recovery from the current and future recessions