Miracle-dz/UniFAR-FTUs huggingface dataset:
Distribution of Population Declines in Large Mammals

Uncertainty in the temporal abundance of species may be attributed to sampling error, demographic or environmental stochasticity, changes in genetic structure, or "catastrophes. " These sources of variability influence the persistence time of small populations (Shaffer 1987; Lande 1988, 1993; Boyce 1992; Caughley 1994), although a consensus on their relative importance has not emerged. And it is not clear whether any such consensus will emerge given the disparate life histories and habitats of the species of interest. What is clear is that much empirical information is still needed regarding the significance and frequency of uncertain "events" in ecological dynamics. Based on Lande's (1993) result that the effects of environmental stochasticity and catastrophes on persistence time are similar in kind, Caughley (1994) argued that the artificial distinction between environmental stochasticity and catastrophes be abandoned. In essence, catastrophes simply represent a tail of the distribution of environmental stochasticity. Young (1994), however, presented an analysis of the across-species frequency of catastrophic declines in abundance of large mammals and concluded that "severe population crashes in populations of large mammals are apparently widespread and not uncommon in nature. " His results show that the number of die-offs between 70% and 90% occurred with higher frequency than those between 25% and 70%. This contradicts the suggestion that catastrophes represent the tail of an environmental stochasticity distribution. Such discrepancy may result from inadequacies in Caughley's (1994) suggestion or Young's (1994) analysis. Our initial concerns with the nature of Young's (1994) data prompted us to suspect the latter. And although Young's synthesis does provide information on the occurrence of "catastrophic" declines, we were not convinced that the results provided a clear or useful picture. The following are five primary concerns with Young's (1994) approach. 1. Reported population declines will be biased toward those of larger proportion, a bias increased by Young's in-
Recovering the Metabolic, Self-Thinning, and Constant Final Yield Rules in Mono-Specific Stands

Competition among plants of the same species often results in power-law relations between measures of crowding, such as plant density, and average size, such as individual biomass. Yoda's self-thinning rule, the constant final yield rule, and metabolic scaling, all link individual plant biomass to plant density and are widely applied in crop, forest, and ecosystem management. These dictate how plant biomass increases with decreasing plant density following a given power-law exponent and a constant of proportionality. While the exponent has been proposed to be universal and thus independent of species, age, environmental, and edaphic conditions, different theoretical mechanisms yield absolute values ranging from less than 1 to nearly 2. Here, eight hypothetical mechanisms linking the exponent to constraints imposed on plant competition are featured and contrasted. Using dimensional considerations applied to plants growing isometrically, the predicted exponent is −3/2 (Yoda's rule). Other theories based on metabolic arguments and network transport predict an exponent of −4/3. These rules, which describe stand dynamics over time, differ from the “rule of constant final yield” that predicts an exponent of −1 between the initial planting density and the final yield attained across stands. The latter can be recovered from statistical arguments applied at the time scale in which the site carrying capacity is approached. Numerical models of plant competition produce plant biomass-density scaling relations with an exponent between −0.9 and −1.8 depending on the mechanism and strength of plant-plant interaction. These different mechanisms are framed here as a generic dynamical system describing the scaled-up carbon economy of all plants in an ecosystem subject to differing constraints. The implications of these mechanisms for forest management under a changing climate are discussed and recent research on the effects of changing aridity and site “quality” on self-thinning are highlighted.
Knowledge, Attitudes, Impact, and Anxiety Regarding COVID-19 Infection Among the Public in China

Objectives: Sufficient knowledge and positive attitudes are crucial to the prevention of COVID-19. However, little is known about public awareness and attitudes regarding COVID-19 in China. The impact of COVID-19 on the societal well-being and anxiety levels of the public has never been documented. The aim of this study was to survey the knowledge, attitudes, impact, and anxiety levels of the people of China in relation to the COVID-19 outbreak. Method: A cross-sectional population survey using an online questionnaire was undertaken between Jan 24 and Feb 24, 2020. The study participants were residents of mainland China over the age of 18 years. The attitude items in this study measured the perceived threat of COVID-19 based on the Health Belief Model. Anxiety was measured with the State-Trait Anxiety Inventory (STAI), a self-reported questionnaire that measure both state (STAI-S), and trait anxiety (STAI-T) Results: A total of 2,446 completed responses were received. The mean and standard deviation (SD) for the total knowledge score was 20.3 (SD ± 2.9) out of a possible score of 23. The social disruption and household economic impact were notable, particularly in provinces with higher cumulative confirmed cases. The majority of responses indicated a low perceived susceptibility of being infected (86.7% [95%CI 85.4–88.1]), with a fair proportion of respondents perceiving a higher severity (62.9% [95% CI 61.0–64.8]). The mean total impact score was 9.9 (SD ± 3.8) out of a possible score of 15. The mean score for STAI-S was 48.7 (SD ± 10.8), whereas the mean STAI-T score was 45.7 (SD ± 8.5). By demographics, women reported significantly higher odds for higher levels of both STAI-S (OR = 1.67) and STAI-T (OR = 1.30) compared to men. People of a younger age were also more likely to experience higher STAI-S and STAI-T. Higher perceived susceptibility and severity and impact were strong predictors of higher levels of STAI-S and STAI-T. Conclusion: Our findings can assist in tailoring public communication to change people's knowledge and attitudes. The present study also underlined the importance of the promotion of mental health during infectious disease outbreaks to help in moderating the perceived threat, social and household economic impact, targeting the vulnerable segment of the population.
A comparison of biodiversity-ecosystem function relationships in alpine grasslands across a degradation gradient on the Qinghai-Tibetan Plateau

To examine biodiversity–ecosystem function relationships in alpine grasslands of the Qinghai–Tibetan Plateau, we compared differences in plant species and functional group diversity (sedges, grasses, legumes and non-leguminous forbs) to aboveground biomass, soil carbon (C) and nitrogen (N) pools and soil loss in five sites that ranged from healthy to severely degraded grasslands. Plant diversity decreased from 36 species in the healthy grassland to 15 species in the severely degraded grassland, and the plant functional groups changed from predominantly grasses and sedges to mostly forbs as the level of degradation increased. Plant biomass and soil pools of C and N decreased whereas soil loss and the amount of bare ground increased across the degradation gradient from healthy to severely degraded grasslands. Simple linear regressions showed strong positive relationships between species diversity and aboveground biomass of sedges, grasses and legumes and between soil C and N pools, but negative relationships between species diversity and non-leguminous forbs and soil loss. Our results provide strong evidence that plant diversity in grasslands on the Qinghai–Tibetan Plateau is positively related to primary productivity, C and N storage in soils and soil conservation, and that grassland degradation is impairing ecosystem function resulting in a loss in ecosystem services.
Wild coffee management and plant diversity in the montane rainforest of southwestern Ethiopia.

Coffea arabica occurs naturally in the montane rainforests of Ethiopia, but large areas of these unique forests have been converted to other land-uses. In the remaining forest, wild coffee is managed and harvested with increasing intensity because of rising coffee prices in the world market. This study evaluated the impact of coffee management on wild coffee populations and the forest vegetation as a basis for conservation planning in southwestern Ethiopia. Vegetation surveys and yield assessments were carried out in unmanaged natural forest and in managed semi-forest coffee (SFC) systems. Analyses show that wild coffee density and coffee yields were low in natural forest (max. 15 kg ha )1 year )1 ). In SFC systems, 30% of the canopy trees and most undergrowth vegetation were removed. This stimulated wild coffee growth and strongly enhanced yields (max. 54 kg ha )1 year )1 ), but severely disturbed forest structure. Species richness increased by 26% because of an increase in species of ruderal and secondary vegetation; however, species richness and abundance of typical forest species declined. Conservation of the natural forest therefore requires the control of wild coffee management. Wild coffee certification is discussed as one tool to reconcile conservation measures and the interests of local farmers.
Rapid Automatized Naming and Explicit Phonological Processing in Children With Developmental Dyslexia: A Study With Portuguese-Speaking Children in Brazil

Many studies have shown that children with reading difficulties present deficits in rapid automatized naming (RAN) and phonological awareness skills. The aim of this study was to examine RAN and explicit phonological processing in Brazilian Portuguese–speaking children with developmental dyslexia and to explore the ability of RAN to discriminate between children with and without dyslexia. Participants were 30 children with a clinical diagnosis of dyslexia established by the Brazilian Dyslexia Association and 30 children with typical development. Children were aged between 7 and 12, and groups were matched for chronological age and sex. They completed a battery of tests that are commonly used in Brazil for diagnosing dyslexia, consisting of the Wechsler Intelligence Test for Children (WISC-IV) as well as tests of single word and non-word reading, RAN, and the profile of phonological abilities test. Results indicate that the cognitive profile of this group of children, with a clinical diagnosis of dyslexia, showed preserved skills in the four subscales of the WISC-IV (verbal comprehension, perceptual reasoning, working memory, and processing speed) and on the profile of phonological abilities test. Groups significantly differed on the reading tests (word and non-word) and RAN measures, with medium to large effect sizes for RAN. Classification and regression tree analysis revealed that RAN was a good predictor for dyslexia diagnosis, with an overall classification accuracy rate of 88.33%.
Nimotuzumab for Patients With Inoperable Cancer of the Head and Neck

EGFR activation induces cell proliferation, neoformation of blood vessels, survival, and metastasis of the cancer cells. Nimotuzumab is an engineered, intermediate affinity anti-EGFR antibody, that apart from other drugs in its class, is very safe and does not cause hypomagnesemia or grade 3–4 cutaneous rash. The antibody inhibits cell proliferation and angiogenesis, activates natural killer cells, stimulates dendritic cell maturation, and induces cytotoxic T cells. Nimotuzumab restores MHC-I expression on tumor cells, hindering one of the EGFR immune-escape ways. The antibody has been extensively studied in 7 clinical trials, concurrently with irradiation or irradiation plus chemotherapy in subjects with inoperable head and neck tumors. Nimotuzumab was safe and efficacious in unfit patients receiving irradiation alone and in subjects treated with cisplatin and radiotherapy. In patients with locally advanced squamous cell carcinomas of the head and neck, nimotuzumab in combination with low dose cisplatin and radiotherapy was superior to cisplatin and radiotherapy in progression free survival, disease free survival, and locoregional tumor control.
Cord Blood Platelet Rich Plasma Derivatives for Clinical Applications in Non-transfusion Medicine

Cord blood platelet rich plasma (CB-PRP) derivatives have been investigated as potential therapeutic agents for the treatment of diverse conditions including ocular surface disease and skin ulcers. We have developed processes for the formulation of several CB-PRP preparations, which have different composition and attributes. Here we describe the molecular characteristics of these preparations and we make recommendations as to their most appropriate clinical application based on functional and immunomodulatory profiles. We show that incubation of adult peripheral blood mononuclear cells (PBMCs) with all three preparations dramatically reduced the production of INFγ and the expression of NKG2D and CD107a in NK, NKT, and T cells thus diminishing their activation, we propose that the likely mechanism is the high levels of soluble NKG2D ligands present in plasma. Of the three preparations we investigated, CB platelet lysate (PL) and platelet releaseate (PR) have higher concentrations of trophic and pro-angiogenic factors, CB platelet poor plasma (PPP) has the lowest concentration of all analytes measured. Based on these finding we propose that CB-PR is the most suitable raw material for skin wound patches, while CB-PL and PPP can be used to prepare eye drops for severe ocular surface pathologies and inflammatory conditions such as corneal ulcers or severe dry eye disease, respectively.
Normative Data for Test of Verbal Fluency and Naming on Ecuadorian Adult Population

Objective: To generate normative data for verbal fluency and naming test in an Ecuadorian adult population. Methods: The sample consisted of 322 healthy adults (18–84 years old) recruited from Quito, Ecuador. The verbal fluency and Boston Naming Test (BNT) were administered as part of a larger comprehensive neuropsychological battery. Multiple linear regression analyses were used to generate the normative data taking into account age, education, and sex. Results: For phonological verbal fluency, results indicated that only education was significantly related to the performance of the letters “A,” “S,” and “M. ” However, the performance on the letter “F” was significantly associated with age and education. For semantic fluency, the performance on “animals” was significantly influenced by age, quadratic age, and education, whereas that for “fruits” was explained by quadratic age, education, and sex. The performance on the BNT was significantly influenced by age and education. A Microsoft Excel-based calculator was created to help clinicians to obtain the normative data on this test. Conclusion: This normative data will help neuropsychologist in Ecuador to use these tests both in research and in their clinical practice to improve the diagnosis of cognitive deficits in the population.
Seasonal Observations at 79°N Glacier (Greenland) From Remote Sensing and in situ Measurements

This study investigates seasonal ice dynamics of Nioghalvfjerdsfjorden or 79°N Glacier, one of the major outlet glaciers of the North East Greenland Ice Stream. Based on remote sensing data and in-situ GPS measurements we show that surface melt water is quickly routed to the ice-bed interface with a direct response on ice velocities measured at the surface. From the temporally highly resolved GPS time series we found summer peak velocities of up to 22% faster than their winter baseline. These average out to 9% above winter velocities when relying on temporally lower resolved velocity estimates from TerraSAR-X intensity offset tracking. From our GPS time series we also found short term ice acceleration after the melt season. By utilizing optical satellite imagery and interferometrically derived digital elevation models we were able to link the post melt season speed-up to a rapid lake drainage event (<24 h) with an estimated drainage volume of 28 × 106 m3. We further highlight that GPS measurements are needed to resolve short term velocity fluctuations with low amplitudes, whereas remote sensing estimates are rather useful for the calculation of general trends in velocity behavior.
Anti-PD-1 Therapy Response Predicted by the Combination of Exosomal PD-L1 and CD28

Anti-PD-1 therapy has been approved for cancer treatment. However, the response rate is unsatisfactory. The expression of PD-L1 in tumor tissues is unreliable to predict the treatment response. Recent studies have suggested that exosomal PD-L1 not only exerts immunosuppressive effects but also plays a significant role in the development of tumor microenvironment. Thus, the present study aims to investigate exosomal PD-L1 in improving its predictive value and efficacy. A total of 44 patients of advanced tumors of several types, treated with anti-PD-1 therapy, were enrolled. Exosomes were collected and purified from plasma. The exosomal PD-L1 was detected with ELISA. The cytokines were measured with the MILLIPLEX magnetic bead assay. Compared to the responders, exosomal PD-L1 of the non-responders was significantly higher than that of the responders (P = 0.010) before the treatment. Concurrently, exosomal PD-L1 and tumor burden decreased when the therapy was effective. And, the baseline expression of CD28 was higher in the responders than that in the non-responders (P = 0.005). Univariate and multivariate analyses validated with 1,000 times bootstrapping suggested that high exosomal PD-L1 and low CD28 expressions were negative factors for progression-free survival (PFS) of the patients who underwent anti-PD-1 treatment. The combination of exosomal PD-L1 and CD28 obtained more area under the curve (AUC) of receiver operating characteristic (ROC) (AUC 0.850 vs. 0.784 vs. 0.678) and showed a higher probability of no progression via nomograph. These findings suggested that the expression of exosomal PD-L1 and CD28 could serve as the predictive biomarkers for clinical responses to anti-PD-1 treatment.
Evaluating the Sustainability Performance of Typical Conventional and Certified Coffee Production Systems in Brazil and Ethiopia Based on Expert Judgements

Increasing consumer awareness on sustainability issues has led to the growing adoption of voluntary sustainability standards in agriculture. This study assesses the sustainability performance of typical conventional and certified coffee production systems in Brazil and Ethiopia based on expert judgements. We apply the SMART-Farm Tool, which represents an operationalization of the SAFA (Sustainability Assessment of Food and Agriculture systems) framework of FAO. Data were collected through expert interviews and uncertainties were estimated using Monte-Carlo simulations. A higher sustainability performance of the certified systems was observed regarding product information (+37%) and transparency (+39%) in Ethiopia. In Brazil, the certified system showed a higher overall sustainability performance compared to the conventional system in the environmental dimension and in some social and governance aspects, e.g., gender equality (+49%) and public health (+36%). Geographical or political conditions and farm type also had a strong influence on the observed sustainability performance. Typical smallholder production systems in Ethiopian coffee production performed comparable in the environmental dimension since all were low-input systems due to economic constraints. The conventional Brazilian system showed a better performance concerning employment relations (+14%) and profitability (+13%), as compared to the certified Brazilian systems, because larger farms were more likely to employ permanent staff and benefit from economies of scale.
Obesity and Sex Affect the Immune Responses to Tick-Borne Encephalitis Booster Vaccination

Obesity has dramatically increased over the last 30 years and reaches according to World Health Organization dimensions of a global epidemic. The obesity-associated chronic low-level inflammation contributes to severe comorbidities and directly affects many immune cells leading to immune dysfunction and increased susceptibility to infections. Thus, prophylaxis against vaccine-preventable diseases is crucial, yet the responsiveness to several vaccines is unclear under obesity. In order to assess the responsiveness to tick-borne encephalitis (TBE) vaccine, we revaccinated 37 obese individuals and 36 normal-weight controls with a licensed TBE vaccine. Metabolic, hormonal, and immunologic profiles along with vaccine-specific humoral and cellular immune responses were evaluated in sera and peripheral blood mononuclear cells (PBMCs) before, 1 week, 4 weeks, and 6 months after TBE booster. Obese adults had significantly increased metabolic (triglycerides, cholesterol ratios, leptin, insulin) and proinflammatory (C-reactive protein) parameters. They showed stronger initial increase of TBE-specific Ab titers (d7_d28) followed by a significantly faster decline after 6 months, which correlated with high body mass index and leptin and insulin levels. The fold increase of Ab-titer levels was significantly higher in obese compared to control males and linked to reduced testosterone levels. Obesity also affected cellular responses: PBMCs of the obese vaccinees had elevated interleukin 2 and interferon γ levels upon antigen stimulation, indicating a leptin-dependent proinflammatory TH1 polarization. The expansion of total and naive B cells in obese might explain the initial increase of Ab titers, whereas the reduced B-memory cell and plasma blast generation could be related to fast Ab decline with a limited maintenance of titers. Among T follicular helper cell (Tfh) cells, the Tfh17 subset was significantly expanded particularly in obese males, where we observed a strong initial Ab increase. Systemic but not local vaccine side effects were more frequent in obese subjects as a possible consequence of their low-grade proinflammatory state. In summary, TBE booster vaccination was effective in obese individuals, yet the faster Ab decline could result in a reduced long-term protection. The sex-based differences in vaccine responses indicate a complex interplay of the endocrine, metabolic, and immune system during obesity. Further studies on the long-term protection after vaccination are ongoing, and also evaluation of primary vaccination against TBE in obese individuals is planned. Clinical Trial Registration: NCT04017052; https://clinicaltrials.gov/ct2/show/NCT04017052.