Miracle-dz/UniFAR-FTUs huggingface dataset:
Suicidal ideation and mental health care: Predisposing, enabling and need factors associated with general and specialist mental health service use in France

Background: Population-based studies have shown that less than one in two individuals reporting suicidal ideation also report past-year mental health service use. Only a few studies have looked at different types of providers consulted. There is a need to better understand the factors associated with different provider combinations of mental health service use in representative samples of individuals with suicidal ideation. Aims: The aim of the current study is to assess, using Andersen’s model of healthcare seeking behaviors, the predisposing, enabling and need factors associated with type of mental health service use in adults with past-year suicidal ideation. Methods: Data were drawn from the 2017 Health Barometer survey, a representative sample of the general population aged 18 to 75 years, among whom 1,128 respondents had reported suicidal ideation in the past year were analyzed. Past-year outpatient mental health service use (MHSU) was categorized into mutually exclusive groups as no use, general practitioner (GP) only; mental health professional (MHP) only; and both GP and MHP. Multinomial regression analyses were used to model mental health service use as a function of predisposing, enabling and need factors. Results: Overall, 44.3% reported past-year MHSU and this was higher in females than males (49.0% vs. 37.6%). Prevalence of GP only use in the overall sample was 8.7%, consulting with GP and MHP was 21.3%, consulting with MHP only was 14.3%. Higher education was associated with increased MHP use. Residing in a rural area was associated with increased GP only use. Presence of a suicide attempt within the year, a major depressive episode and role impairment were associated with consulting a GP and MHP, and MHP only, but not GP only. Conclusions: When controlling for need and predisposing factors, socio-economic factors related to employment and income were associated with higher levels of consulting with mental health professionals.
Usefulness of apparent diffusion coefficient values for distinguishing between squamous cell carcinoma and malignant salivary gland tumor of the head and neck

Purpose The aim of the study was to assess the usefulness of apparent diffusion coefficient (ADC) values for differentiating between SCC and malignant salivary gland tumors of the head and neck. Materials and methods This retrospective cross-sectional study was conducted on 29 patients with SCCs and 10 patients with malignant salivary gland tumors who underwent pretreatment MRI of the head and neck. The minimum and average ADC values of the tumors were measured, with normalized tumor to spinal cord ADC ratios generated. Comparisons of ADC values and normalized ADC ratios between the two tumor types were performed using the unpaired t-test. Results The minimum and average ADC values and normalized average ADC ratios of SCCs (753.17 ± 214.47 × 10−6 mm2/s, 848.79 ± 250.13 × 10−6 mm2/s, and 0.92 ± 0.25, respectively) were significantly lower than those of malignant salivary gland tumors (1084.90 ± 242.60 × 10−6 mm2/s, 1305.90 ± 270.99 × 10−6 mm2/s, and 1.58 ± 0.31, respectively; all p < 0.001). A cutoff value of 1.31 for the normalized average ADC ratio was used to distinguish between SCCs and malignant salivary gland tumors and achieved an area under the curve of 0.93, sensitivity of 96.6%, specificity of 90%, and accuracy of 94.6%. Conclusion ADC value measurement could help differentiate between SCCs and malignant salivary gland tumors.
ORF45, a multifunctional immediate early and tegument protein of KSHV

Kaposi sarcoma‐associated herpesvirus (KSHV) is the etiological agent of several human diseases, including Kaposi sarcoma, primary effusion lymphoma, and a subset of multicentric Castleman's disease. KSHV uses its gene products to manipulate many aspects of the host responses during its life cycles. Among KSHV‐encoded proteins, ORF45 is unique in both temporal and spatial expression: it is expressed as an immediate‐early gene product and is an abundant tegument protein contained in the virion. ORF45 is specific to the gammaherpesvirinae subfamily but the homologs share only very limited homology and differ dramatically in protein length. In the past two decades, we and others have shown that ORF45 plays critical roles in immune evasion, viral replication, and virion assembly by targeting various host and viral factors. Herein, we summarize our current knowledge of ORF45 throughout the KSHV life cycle. We discuss the cellular processes targeted by ORF45 with emphasis on the modulation of host innate immune responses and rewiring the host signaling through impacting three major posttranslational modifications: phosphorylation, SUMOylation, and ubiquitination.
Propofol disrupts alpha dynamics in functionally distinct thalamocortical networks during loss of consciousness

Significance Although anesthetic drugs are known to lower arousal, it is unclear how anesthesia impacts perceptual and cognitive processing. Diminished arousal has been associated with prominent brain oscillations such as the slow wave, but functional roles for other anesthesia-induced rhythmic changes have not been proposed. During waking states, brain oscillations are understood to be involved in a variety of sensory and cognitive processes mediated by circuits connecting posterior or prefrontal cortices with the thalamus. This study shows that propofol disrupts alpha oscillations (~10 cycles/s) in posterior circuits that mediate sensory processing and induces an alpha oscillation in prefrontal cognitive circuits that normally operate at higher frequencies.
Bayesian structured additive distributional regression for multivariate responses

We propose a unified Bayesian approach for multivariate structured additive distributional regression analysis comprising a huge class of continuous, discrete and latent multivariate response distributions, where each parameter of these potentially complex distributions is modelled by a structured additive predictor. The latter is an additive composition of different types of covariate effects, e.g. non‐linear effects of continuous covariates, random effects, spatial effects or interaction effects. Inference is realized by a generic, computationally efficient Markov chain Monte Carlo algorithm based on iteratively weighted least squares approximations and with multivariate Gaussian priors to enforce specific properties of functional effects. Applications to illustrate our approach include a joint model of risk factors for chronic and acute childhood undernutrition in India and ecological regressions studying the drivers of election results in Germany.
CRISPR-assisted transcription activation by phase-separation proteins

Abstract The clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 system has been widely used for genome engineering and transcriptional regulation in many different organisms. Current CRISPR-activation (CRISPRa) platforms often require multiple components because of inefficient transcriptional activation. Here, we fused different phase-separation proteins to dCas9-VPR (dCas9-VP64-P65-RTA) and observed robust increases in transcriptional activation efficiency. Notably, human NUP98 (nucleoporin 98) and FUS (fused in sarcoma) IDR domains were best at enhancing dCas9-VPR activity, with dCas9-VPR-FUS IDR (VPRF) outperforming the other CRISPRa systems tested in this study in both activation efficiency and system simplicity. dCas9-VPRF overcomes the target strand bias and widens gRNA designing windows without affecting the off-target effect of dCas9-VPR. These findings demonstrate the feasibility of using phase-separation proteins to assist in the regulation of gene expression and support the broad appeal of the dCas9-VPRF system in basic and clinical applications.
Compressed Sensing o the Grid

We consider the problem of estimating the frequency components of a mixture of s complex sinusoids from a random subset of n regularly spaced samples. Unlike previous work in compressed sensing, the frequencies are not assumed to lie on a grid, but can assume any values in the normalized frequency domain [0; 1]. We propose an atomic norm minimization approach to exactly recover the unobserved samples. We reformulate this atomic norm minimization as an exact semidenite program. Even with this continuous dictionary, we show that most sampling sets of size O(s logs logn) are sucient to guarantee the exact frequency estimation with high probability, provided the frequencies are well separated. Extensive numerical experiments are performed to illustrate the eectiveness of the proposed method.
New dilated LMI characterizations for continuous-time control design and robust multiobjective control

It has been recognized that the dilation of the LMI characterizations has new potentials in dealing with such involved problems as multiobjective control, robust performance analysis or synthesis for real polytopic uncertainty and so on. Contrary to the success in this direction in the discrete-time setting, analogous characterizations in the continuous-time setting are still open and challenging. The main contribution of the paper is to propose a general procedure to construct such dilated LMI characterizations for continuous-time control design. Because of our particular procedure, the dilated LMI characterizations are proved to have some very nice and interesting features that are to some extent analogous to the ones already obtained in the discrete-time setting.
The enhanced generation of motor neurons from mESCs by MgAl layered double hydroxide nanoparticles

The committed differentiation of stem cells into neurons is a promising therapeutic strategy for neurological diseases. Predifferentiation of transplanted stem cells into neural precursors could enhance their utilization and control the direction of differentiation. Embryonic stem cells with totipotency can differentiate into specific nerve cells under appropriate external induction conditions. Layered double hydroxide (LDH) nanoparticles have been proven to regulate the pluripotency of mouse ESCs (mESCs), and LDH could be used as carrier in neural stem cells for nerve regeneration. Hence, we sought to study the effects of LDH without loaded factors on mESCs neurogenesis in this work. A series of characteristics analyses indicated the successful construction of LDH nanoparticles. LDH nanoparticles that may adhere to the cell membranes had insignificant effect on cell proliferation and apoptosis. The enhanced differentiation of mESCs into motor neurons by LDH was systematically validated by immunofluorescent staining, quantitative real-time PCR analysis and western blot analysis. In addition, transcriptome sequencing analysis and mechanism verification elucidated the significant regulatory roles of focal adhesion signaling pathway in the enhanced mESCs neurogenesis by LDH. Taken together, the functional validation of inorganic LDH nanoparticles promoting motor neurons differentiation provide a novel strategy and therapeutic prospect for the clinical transition of neural regeneration.
On the rotation of the chemically peculiar magnetic star 56 Arietis

This study used extensive sets of phase resolved photometric and spectroscopic data obtained by the authors and supplemented by that from the literature to investigate the light and equivalent width variations of the mCP star 56 Ari. Its rotational period is found to be increasing at a rate of about 2 s per 100 years. In addition there is evidence for a second period whose length is about 5 years which is attributed to the precession of the axis of rotation.
Is stereotactic body radiotherapy an effective treatment in metastatic lung cancer with oligoprogressive disease?

Abstract Background Oligoprogression (OPD) is defined as a condition where limited progression (1–3 metastases) is observed in patients undergoing systemic cancer treatment. In this study we investigated the impact of stereotactic body radiotherapy (SBRT) in patients with OPD from metastatic lung cancer. Material and Methods Data from a cohort of consecutive patients with SBRT treated between June 2015 and August 2021 were collected. All extracranial metastatic sites of OPD from lung cancer were included. Dose regimens consisted of mainly 24 in 2 fractions, 30–51 Gy in 3 fractions, 30–55 Gy in 5 fractions, 52.5 Gy in 7 fractions and 44–56 Gy in 8 fractions. Kaplan–Meier method was used to calculate Overall Survival (OS), Local Control (LC), and Disease-Free Survival (DFS) from the start date of SBRT to the event. Results Sixty-three patients, 34 female and 29 males were included. Median age was 75 years (range 25–83). All patients received concurrent systemic treatment before the start of the SBRT: 19 chemotherapy (CT), 26 CT plus immunotherapy (IT) or Tyrosin kinase inhibitors (TKI) and 18 IT/TKI. SBRT was delivered to the lung (n = 29), mediastinal node (n = 9), bone (n = 7), adrenal gland (n = 19), other visceral metastases (1) and other node metastases (n = 4). After a median follow-up of 17 months, median OS was 23 months. LC was 93% at 1 year and 87% at 2 years. DFS was 7 months. According to our results, there was no statistically significant correlation between prognostic factors and OS after SBRT in OPD patients. Conclusions Median DFS was 7 months, translating into the continuation of effective systemic treatment as other metastases grow slowly. In patients with oligoprogression disease, SBRT is a valid and efficient treatment that may enable postponing the switch of systemic line.
Neuroregeneration and immune response after neurorrhaphy are improved with the use of heterologous fibrin biopolymer in addition to suture repair alone

Peripheral nerve injuries result in impaired neuromuscular interactions, leading to morphological and functional alterations. Adjuvant suture repair methods have been used to improve nerve regeneration and modulate the immune response. Heterologous fibrin biopolymer (HFB), a scaffold with adhesive properties, plays a critical role in tissue repair. The aim of this study is to evaluate neuroregeneration and immune response focusing on neuromuscular recovery, using suture‐associated HFB for sciatic nerve repair.
Evaluation of combination therapies with colistin in an experimental mouse pneumonia model induced by carbapenem‐resistant Acinetobacter baumannii strain

The treatment options are limited in Acinetobacter baumannii infections. In this study, the effectiveness of colistin monotherapy and combinations of colistin with different antibiotics were investigated in an experimental pneumonia model induced by carbapenem‐resistant A. baumannii strain. Mice in the study were divided into five groups as control (no treatment), colistin monotherapy, colistin + sulbactam, colistin + imipenem, and colistin + tigecycline combinations. The modified experimental surgical pneumonia model of Esposito and Pennington was applied to all groups. The presence of bacteria in blood and lung samples was investigated. Results were compared. In blood cultures, while there was no difference between the control and colistin groups, there was a statistical difference between the control and the combination groups (P = 0.029). When the groups were compared in terms of lung tissue culture positivity, there was a statistical difference between the control group and all treatment groups (colistin, colistin + sulbactam, colistin + imipenem, and colistin + tigecycline) (P = 0.026, P < 0.001, P < 0.001, and P = 0.002, respectively). The number of microorganisms that grew in the lung tissue was found to be statistically significantly lower in all treatment groups in comparison with the control group (P = 0.001). Both monotherapy and combination therapies of colistin were found to be effective in the treatment of carbapenem‐resistant A. baumannii pneumonia, but the superiority of combination therapies over colistin monotherapy has not been demonstrated.
Reynolds-stress and dissipation-rate budgets in a turbulent channel flow

The Budgets For The Reynolds Stresses And For The Dissipation Rate Of The Turbulence Kinetic Energy Are Computed Using Direct Simulation Data Of A Turbulent Channel Flow. The Budget Data Reveal That All The Terms In The Budget Become Important Close To The Wall. For Inhomogeneous Pressure Boundary Conditions, The Pressure—Strain Term Is Split Into A Return Term, A Rapid Term And A Stokes Term. The Stokes Term Is Important Close To The Wall. The Rapid And Return Terms Play Different Roles Depending On The Component Of The Term. A Split Of The Velocity Pressure-Gradient Term Into A Redistributive Term And A Diffusion Term Is Proposed, Which Should Be Simpler To Model. The Budget Data Are Used To Test Existing Closure Models For The Pressure—Strain Term, The Dissipation Rate, And The Transport Rate. In General, Further Work Is Needed To Improve the models.
How Will Climate Change Affect Human Health?

• A submitted manuscript is the version of the article upon submission and before peer-review. There can be important differences between the submitted version and the official published version of record. People interested in the research are advised to contact the author for the final version of the publication, or visit the DOI to the publisher's website. • The final author version and the galley proof are versions of the publication after peer review. • The final published version features the final layout of the paper including the volume, issue and page numbers.
Identifying correlates of salt reduction practices among rural, middle-aged Muslim Indonesians with hypertension through structural equation modeling

Background: In 2016, the World Health Organization recommended salt reduction strategies. In most low- and middle-income countries, little is known about what causes people to reduce their salt intake. Aim: In rural West Java, Indonesia, we conducted a cross-sectional survey to describe self-reported salt reduction practices among middle-aged Muslims with hypertension (n = 447) and to identify correlates of salt reduction. Methods: We developed a questionnaire with Likert scales to measure self-reported frequency of efforts to reduce salt intake, and degree of agreement/disagreement with 51 statements about variables hypothesized to influence salt reduction practices. We compared groups using t-tests and one-way ANOVAs. Through one-factor confirmatory factor analysis and structural equation modeling, we identified correlates of salt reduction practices. Results: About 45% of participants reported regularly reducing their salt intake; only 12.8% reported never attempting. Men reported higher social barriers, while women reported higher family support and spiritual support. Overall, we found that participants’ frequency of effort to reduce their salt intake was associated with a constellation of six correlates. Salt reduction practices were directly positively associated with prior health/illness experiences (β = 0.25), and by seeking health information (β = 0.24). Seeking health information was in turn positively associated with prior health/illness experiences (β = 0.34), receiving support from health professionals (β = 0.23) and Islamic spiritual practice (β = 0.24). Salt reduction practices were negatively associated with environmental barriers to healthful eating practices (β = -0.14). Conclusion: In this population, reinforcing positive correlates identified in this study and mitigating against negative correlates may foster salt reduction practices.
C*‐Nuclearity implies CPAP

In this paper we show: A C*-algebra A with identity e is C*-nuclear (i.e. “nuclear” in the sense of LANCE [3, p. 159] or “property T” in the sense of TAKESAKI [6] if and only if the identity operator idA on A can be approximated in the strong operator topology by completely positive linear operators V from A into A of finite rank with norm one and V(e)=e. From which follows that every C*-nuclear C*-algebra (possible without identity) possesses the CPAP of LANCE [3, def. 3.5. ]. This answers questions of LANCE [3, p. 173] and SAKAI [5, p. 64].
Reflection and transmission by reinforced concrete - numerical and asymptotic analysis

To model the reflection and transmission properties of reinforced concrete, we develop a method of moments/Green's function (MoM/GF) model for a wire grid embedded in a lossy dielectric slab. Since the scattering by a wire grid is dominated by wires that are parallel to the incident electric field, a two-dimensional (2D) model with a grid of straight, parallel wires is used. The number of wires is finite, but can be large. The dielectric slab can be thin or thick, and it is of infinite transverse extent. The source and field points are in the near field. The wire currents are solved for by the MoM. Certain Green's functions for the dielectric slab are evaluated by two different methods: 1) exact numerical evaluation of Sommerfeld integrals (SI); 2) the high frequency asymptotic approximation, via the saddle point method, which yields the geometrical optics (GO) result. We explore the range dependence and angular dependence of the reflected and transmitted fields. The influence of surface waves and wire-wire interactions is also examined.
Confinement regime transitions in ASDEX

The authors give an overview of the different confinement regimes observed on ASDEX and compare the changes during the transition phases with qualitative tendencies suggested by theoretical models. The transitions discussed are those between purely Ohmic heating and additional heating in the L-regime between the L- and the H-regime and between discharges with flat and peaked electron density profiles.
When Do Controlling Shareholders “Over-invest”? The Disciplinary Effect of Product Market Competition

This study examines the effect of the interaction between controlling shareholder ownership and product market competition on investment inefficiency in Korea. Consistent with classical agency theory, this study finds that the lower the controlling shareholder ownership, the greater the overinvestment. However, this relationship strengthens in noncompetitive markets but disappears in competitive markets. This suggests that product market competition has a disciplinary effect on the incentive of controlling shareholders to pursue private benefits. This study has implications for the disciplinary effect of competition and expands the literature on agency theory in emerging countries with concentrated ownership structures.
A class of connections governing parallel transport along density matrices

A class of connections governing parallel transport along nondegenerate density matrices is discussed. These connections are given by certain analytic functions. We develop a calculus for operator‐valued differential forms, which enables us to calculate the curvature of these connections. The class under consideration contains a non‐Abelian generalization of Berry’s phase recently proposed by Uhlmann.
Efficient Calculation of Switching Overvoltages Considering Corona Attenuation

This article applies the Unscented Transform to calculate the 2%-value of switching overvoltages when considering the impact of trapped charge and corona attenuation. Simulations were performed using a piecewise linear corona model for twin- and triple-conductor lines. The proposed method was compared to Monte Carlo methods through simulations in PSCAD. The method is shown to be able to estimate the 2%-value with comparable accuracy to methods used in industry today, but with only one fifth of the number of calculations.