Miracle-dz/UniFAR-FTUs huggingface dataset:
Genome-wide gene expression analysis supports a developmental model of low temperature tolerance gene regulation in wheat ( Triticum

Background: To identify the genes involved in the development of low temperature (LT) tolerance in hexaploid wheat, we examined the global changes in expression in response to cold of the 55,052 potentially unique genes represented in the Affymetrix Wheat Genome microarray. We compared the expression of genes in winter-habit (winter Norstar and winter Manitou) and spring-habit (spring Manitou and spring Norstar)) cultivars, wherein the locus for the vernalization gene Vrn-A1 was swapped between the parental winter Norstar and spring Manitou in the derived near-isogenic lines winter Manitou and spring Norstar. Global expression of genes in the crowns of 3-leaf stage plants cold-acclimated at 6°C for 0, 2, 14, 21, 38, 42, 56 and 70 days was examined. Results: Analysis of variance of gene expression separated the samples by genetic background and by the developmental stage before or after vernalization saturation was reached. Using gene-specific ANOVA we identified 12,901 genes (at p < 0.001) that change in expression with respect to both genotype and the duration of cold-treatment. We examined in more detail a subset of these genes (2,771) where expression was highly influenced by the interaction between these two main factors. Functional assignments using GO annotations showed that genes involved in transport, oxidation-reduction, and stress response were highly represented. Clustering based on the pattern of transcript accumulation identified genes that were up or down-regulated by cold-treatment. Our data indicate that the cold-sensitive lines can up-regulate known cold-responsive genes comparable to that of cold-hardy lines. The levels of expression of these genes were highly influenced by the initial rate and the duration of the gene ’ s response to cold. We show that the Vrn-A1 locus controls the duration of gene expression but not its initial rate of response to cold treatment. Furthermore, we provide evidence that Ta.Vrn-A1 and Ta.Vrt1 originally hypothesized to encode for the same gene showed different patterns of expression and therefore are distinct. Conclusion: This study provides novel insight into the underlying mechanisms that regulate the expression of cold-responsive genes in wheat. The results support the developmental model of LT tolerance gene regulation and demonstrate the complex genotype by environment interactions that determine LT adaptation in winter annual cereals. genes involved in signal transduction, transport and oxi-dation-reduction pathways.
?magnetic fI4d efl’ccts on ee11s oft1 t1*1e of calcium signaling immune sten;

During the past decade considerable evidence has accumulated demonstrating that nonthermal exposures of cells of the immune system to extremely low-frequency (ELF) electromagnetic fields (< 300 Hz) can elicit cellular changes that might be relevant to in vivo immune activity. A similar responsiveness to nonionizing electromagnetic energy in this frequency range has also been documented for tissues of the neuroendocrine and musculoskeletal system. However, knowledge about the underlying biological mechanisms by which such fields can induce cellular changes is still very limited. It is generally believed that the cell membrane and Ca2-regulated activity is involved in bioactive ELF field coupling to living systems. This article begins with a short review of the current state of knowledge concerning the effects of nonthermal levels of ELF electromagnetic fields on the biochemistry and activity of immune cells and then closely examines new results that suggest a role for Ca2 in the induction of these cellular field effects. Based on these findings it is proposed that membrane-mediated Ca2 signaling processes are involved in the mediation of field effects on the immune system. -Walleczek, field effects on cells of the immune system: the role of calcium signaling.
Narcissists(cid:2) social pain seen only in the brain

Narcissism is a complex phenomenon, involving a level of defensive self-enhancement. Narcissists have avoidant attachment styles, maintain distance in relationships and claim not to need others. However, they are especially sensitive to others(cid:2) evaluations, needing positive reflected appraisals to maintain their inflated self-views, and showing extreme responses (e.g. aggression) when rejected. The current study tested the hypothesis that narcissists also show hypersensitivity in brain systems associated with distress during exclusion. We measured individual differences in narcissism (Narcissistic Personality Inventory) and monitored neural responses to social exclusion (Cyberball). Narcissism was significantly associated with activity in an a priori anatomically defined social pain network (anterior insula, dorsal anterior cingulate cortex and subgenual anterior cingulate cortex) during social exclusion. Results suggest hypersensitivity to exclusion in narcissists may be a function of hypersensitivity in brain systems associated with distress, and suggests a potential pathway that connects narcissism to negative consequences for longer-term physical and mental health(cid:3)findings not apparent with self-report alone.
Cost-effectiveness of ﬁrst-line antiretroviral therapy for HIV-infected African children less than 3 years of age

Background: The International Maternal, Pediatric, and Adolescent Clinical Trials P1060 trial demonstrated superior outcomes for HIV-infected children less than 3 years old initiating antiretroviral therapy (ART) with lopinavir/ritonavir compared to nevirapine, but lopinavir/ritonavir is four-fold costlier. Design/methods: We used the Cost-Effectiveness of Preventing AIDS Complications (CEPAC)-Pediatric model, with published and P1060 data, to project outcomes under three strategies: no ART; ﬁrst-line nevirapine (with second-line lopinavir/ritonavir); and ﬁrst-line lopinavir/ritonavir (second-line nevirapine). The base-case examined South African children initiating ART at age 12 months; sensitivity analyses varied all key model parameters. Outcomes included life expectancy, lifetime costs, and incremental cost-effectiveness ratios [ICERs; dollars/year of life saved ($/YLS)]. We considered interventions with ICERs less than 1 (cid:1) per-capita gross domestic product (South Africa: $7500)/YLS as ‘very cost-effective,’ interventions with ICERs below 3 (cid:1) gross domestic product/YLS as ‘cost-effective,’ and interventions leading to longer life expectancy and lower lifetime costs as ‘cost-saving’. Results: Projected life expectancy was 2.8 years with no ART. Both ART regimens markedly improved life expectancy Conclusions: On the basis of P1060 data, ﬁrst-line lopinavir/ritonavir leads to longer life expectancy and is cost-saving or very cost-effective compared to ﬁrst-line nevirapine. This supports WHO guidelines, but increasing access to pediatric ART is critical regardless of the regimen used.
Substorm‐associated explosive magnetic field stretching near the earthward edge of the plasma sheet

We report a detailed analysis of explosive local magnetic field line stretching just before dipolarization observed by one of Time History of Events and Macroscale Interactions during Substorms (THEMIS) satellites during the pseudo‐breakup followed by local substorm of 6 January 2008. At the end of the substorm growth phase, this satellite (THEMIS‐C) was located at r ~ 6.3 RE near the convection boundary of 10 keV electrons. Penetration of the hot electron plasma sheet to the region of trapped energetic ions was a precondition for the substorm onset in the premidnight sector. Observed oscillations of fields and particles with period 50–60 s are consistent with the ballooning mode in the near‐Earth magnetotail and with the near‐Earth initiation current disruption model. Basing on the simple line‐current model, the explosive stretching and following dipolarization observed by THEMIS‐C satellite are interpreted as a manifestation of the magnetospheric generator of the 3‐D meridional current system with the driving electric field in the meridional direction during nonlinear growth of ballooning instability when non‐MHD processes are also turning on.
Finding MEMO—Emerging Evidence for MEMO1 (cid:48) s Function in Development and Disease

: Although conserved throughout animal kingdoms, the protein encoded by the gene Mediator of ERBB2 Driven Cell Motility 1 or MEMO1 , has only recently come into focus. True to its namesake, MEMO1 ﬁrst emerged from a proteomic screen of molecules bound to the ERBB2 receptor and was found to be necessary for e ﬃ cient cell migration upon receptor activation. While initially placed within the context of breast cancer metastasis—a pathological state that has provided tremendous insight into MEMO1 (cid:48) s cellular roles—MEMO1 (cid:48) s function has since expanded to encompass additional cancer cell types, developmental processes during embryogenesis and homeostatic regulation of adult organ systems. Owing to MEMO1 (cid:48) s deep conservation, a variety of model organisms have been amenable to uncovering biological facets of this multipurpose protein; facets ranging from the cellular (e.g., receptor signaling, cytoskeletal regulation, redox ﬂux) to the organismal (e.g., mineralization and mineral Although these facets emerge at the intersection of numerous biological and human disease processes, how and if they are interconnected remains to be resolved. Here, we review our current understanding of this ‘enigmatic’ molecule, its role in development and disease and open questions emerging from these previous studies. (mDia1), Epidermal Growth Factor Receptor (EGF / EGFR), epithelial-mesenchymal transition (EMT), estrogen (E 2 ), estrogen receptor (ER), erythroblastic oncogene B (ERBB), Extracellular Signal-Regulated Kinase (ERK), extranuclear estrogen receptor (enER), Fibroblast Growth Factor 2 (FGF2), Fibroblast Growth Factor Receptor (FGFR), Fibroblast Growth Receptor Substrate (FRS), Glycogen Synthase Kinase-3 β (GSK3ß), GRB2-Associated-Binding Protein 1 (GAB1), Growth Factor Receptor-Bound Protein 2 (GRB2), Human Epidermal Growth Factor Receptor 2 (HER2), human umbilical vein endothelial cell line (HUVECs), Insulin Receptor Substrate 1 (IRS1), Insulin-like growth factor (IGF / IGFR), International Mouse Phenotyping Consortium (IMPC), loss-of-function (LOF), Mediator of Cell Motility 1 (MEMO1), MEMO1 circular RNA (Circ-MEMO1), Mitogen-Activated Protein Kinase (MAPK), mouse embryonic ﬁbroblasts (MEFs), NADPH Oxidase 1 (NOX1), Neural Wiskott Aldrich Syndrome Protein (N-WASP), non-small cell lung cancer (NSCLC), Nuclear Factor-kB (NFkB), Nuclear Respiratory Factor (NRF), phosphatidylinositol phospholipase C (PLC1), phospho-Tyrosine (pY), tyrosine (Y), Phosphoinositide 3-Kinase (PI3K), Phospholipase C γ (PLC γ ), Platelet-Derived Growth Factor (PDGF), Protein Kinase B (AKT), radial glial progenitors (RGCs), Ras Homolog Family Member A (RhoA), reactive oxygen species (ROS), Src homology and collagen 1 (SHC), SH2 domain-containing Phosphatase-2 (SHP2),
The minC Combination of Belief Functions: Derivation and Formulas

: Principal ideas of the minC combination are recalled. A mathematical structure of generalized frames of discernment is analysed and formalized. A generalized schema for a computation of the minC combination is presented. Conﬂicting belief masses redistribution among non-conﬂicting focal elements is overviewed. Final general formulas for computation of the minC combination are presented. Some examples of computation of the minC combination follow. A brief comparison of the minC combination with other combination rules is presented. Related works and approaches and some open problems for a future research are referred in the end.
Identi cation of Chondroitin Polymerizing Factor (CHPF) as Tumor Promotor in Cholangiocarcinoma through Regulating Cell Proliferation, Cell Apoptosis and Cell Migration

Xiaohui Duan Hunan Provincial People's Hospital, The First-a liated Hospital of Hunan Normal University Jianhui Yang Hunan Provincial People's Hospital, The First-a liated Hospital of Hunan Normal University Bo Jiang Hunan Provincial People's Hospital, The First-a liated Hospital of Hunan Normal University Wenbin Duan Hunan Provincial People's Hospital, The First-a liated Hospital of Hunan Normal University Rongguang Wei Hunan Provincial People's Hospital, The First-a liated Hospital of Hunan Normal University Hui Zhang Hunan Provincial People's Hospital, The First-a liated Hospital of Hunan Normal University Xianhai Mao (  clinicaldor@sina.com ) Hunan Provincial People's Hospital, The First-a liated Hospital of Hunan Normal University https://orcid.org/0000-0003-1377-5246
Search for B0 -> K*0 nu nubar Using One Fully Reconstructed B Meson

We present a search for the rare decay B0 -> K*0 nu nubar, using a data sample of 492 fb^-1 collected with the Belle detector at the KEKB e+e- collider. Signal candidates are required to have an accompanying B meson fully reconstructed in one of the hadronic modes and signal-side particles consistent with a single K*0 meson. No significant signal is observed in the data sample and we set a 90% confidence level upper limit of 3.4 x 10^-4 on the branching fraction.
Deﬁning Urban Freight Microhubs: A Case Study Analysis

: Urban freight distribution has confronted several challenges, including negative environmental, social, and economic impacts. Many city logistics initiatives that use the concept of Urban Consolidation Centers (UCCs) have failed. The failure of many UCCs does not mean that the idea of additional terminals or microhubs should be rejected. There is limited knowledge about the advan-tages and disadvantages of using microhubs, requiring further exploration of this concept. To expand this knowledge, this research combines 17 empirical cases from Europe and North America to develop a framework for classifying different microhubs typologies. This research presents an integrated view of the cases and develops a common language for understanding microhub typologies and deﬁnitions. The research proposes microhubs as an important opportunity to improve urban freight sustainability and efﬁciency and one possible step to manage the challenge of multi-sector collaboration.
The Potential Effect of the Angiotensin-Converting Enzyme 2 (ACE2) Receptor of 2019-nCoV in Lung Adenocarcinoma Patients on Age

Background The 2019-nCoV epidemic is the public health emergency that has had the greatest impact on the world. Our study aimed to better understand the underlying mechanisms and function of angiotensin-converting enzyme 2 (ACE2) receptor of 2019-nCoV on lung adenocarcinoma patients (LUAD), and provide a theoretical basis for early diagnosis, prognosis and targeted therapy of 2019-nCoV. This study focuses on the expression level, functions, mutation rate, and copy number variations (CNVs) of ACE2 in LUAD using an extensive bioinformatics data mining process. The interaction between ACE2 expression and clinical-pathological parameters of patients with LUAD was investigated using UALCAN. Also, the essential biological features, single nucleotide variations (SNVs), CNVs, and pathway activities of genes interacting with ACE2 in these cancers were further analyzed.
Extended Dust Emission and Atomic Hydrogen: A Reservoir of Diffuse H2 in NGC 1068

We report on sensitive submillimeter imaging observations of the prototype Seyfert 2/starburst galaxy NGC 1068 at 850 and 450 μm using the Submillimeter Common-User Bolometer Array on the James Clerk Maxwell Telescope. We find clear evidence of dust emission associated with the extended H I component that, together with the very faint 12CO J=1-0 emission, gives a gas-to-dust ratio of Mgas/Mdust~70-150. This contrasts with the larger ratio Mgas/Mdust~330 that is estimated within a galactocentric radius of r≤1.36 kpc, where the gas is mostly molecular and starburst activity occurs. The large gas-to-dust ratio that is found for the starburst region is attributed to a systematic overestimate of the molecular gas mass in starburst environments when the luminosity of the 12CO J=1-0 line and a standard Galactic conversion factor are used. On the other hand, submillimeter imaging proves to be a more powerful tool than conventional CO imaging for revealing the properties of the diffuse H2 that coexists with H I. This molecular gas phase is characterized by low densities [n(H2)<103 cm−3], very faint emission from subthermally excited CO, and contains more mass than H I, namely, M(H2)/M(H I) ~ 5.
The Determinants Affecting Environmental Disclosure in the High Profile Companies in Indonesia

This study aims to analyze whether the board of commissioners, managerial ownership, media coverage, firm size, and profitability can affect the disclosure of the environment. The population of this study is a high profile company listed on the Indonesia Stock Exchange in 2011-2015 as many as 83 companies. This research used purposive sampling method and elected 11 companies as sample with 55 unit of analysis. The results show that board of commissioners, media coverage, and company size have a positive effect on environmental disclosure. However, managerial ownership and profitability cannot affect the disclosure of the environment. The conclusions of this study are factors that proved to have a positive effect on the disclosure of the environment are board of commissioners, media coverage, and company size.
Gene expression analysis identifies potential biomarkers of neurofibromatosis type 1 including adrenomedullin Running Title : Adrenomedullin as an NF 1 serum biomarker

Divisions of Experimental Hematology and Cancer Biology, Pediatric Informatics, and Human Genetics, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave., Cincinnati, OH, 45229; University Hospital Hamburg-Eppendorf, Martinistraße 52, D – 20246, Hamburg, Germany; Department of Molecular Genetics and Microbiology, Box 100245, University of Florida, Gainesville, Florida; Laboratori de Recerca Translacional, Institut Català d'OncologiaIDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain; Statistics and Epidemiology Unit; RTI International 2951 Flowers Road, South Chamblee, GA 30341; and The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, 725 North Wolfe St., Baltimore, MD 21205
MAKING THE SUBTLE THE OBVIOUS: UNDERREPRESENTED STUDENTS ON A HISTORICALLY WHITE CAMPUS AND IMPLICATIONS FOR INSTITUTIONAL FIT AND STRESS by

Amid growing concern over the campus racial climate for historically marginalized populations on historically White college campuses, the current study examined how a student's institutional fit and sense of belonging is affected by stress. Secondary data from a section of the Survey of College Adjustment and Cultural Diversity Issues in Higher Education that focused on issues of satisfaction with the university were obtained from 267 White, 287 African American, 230 Asian American, and 171 Latina/o junior year students. Five components of the university environment and the student's self-reported opinion on issues surrounding their experience — academic sense of belonging, social sense of belonging, discrimination, stress, and institutional fit — were analyzed using confirmatory factor analysis and structural equation modeling. Findings suggest that students from all of racial/ethnic groups sampled demonstrated that stress predicted their fit to the institution. For African American and Asian American students, experiences with discrimination were additional predictors of their institutional fit. Compared to White students, the academic sense of belonging for all groups of students of color more significantly predicted stress than the social sense of belonging. This finding suggests that there is something within the academic setting of universities that explains the stress that students of color experience. In turn, the stressors that students of color experience affect their institutional fit. Therefore, this finding t t ti
Dynamics of invitro acquisition of resistance by Candida parapsilosis to di¡erent azoles

Candida parapsilosis is a common isolate from clinical fungal infectious episodes. Resistance of C. parapsilosis to azoles has been increasingly reported. To analyse the development of resistance in C. parapsilosis , four azole-susceptible clinical strains and one American Type Culture Collection type strain were cultured in the presence of ﬂuconazole, voriconazole and posaconazole at different concentrations. The isolates developed variable degrees of azole resistance according to the antifungal used. Fluconazole was the fastest inducer while posaconazole was the slowest. Fluconazole and voriconazole induced resistance to themselves and each other, but not to posaconazole. Posaconazole induced resistance to all azoles. Developed resistance was stable; it could be conﬁrmed after 30 days of subculture in drug-free medium. Azole-resistant isolates revealed a homogeneous population structure; the role of azole transporter efﬂux pumps was minor after evaluation by microdilution and cytometric assays with efﬂux pump blockers (verapamil, ibuprofen and carbonyl cyanide 3-chloro-phenylhydrazone). We conclude that the rapid development of azole resistance occurs by a mechanism that might involve mutation of genes responsible for ergosterol biosynthesis pathway, stressed by exposure to antifungals.
Thiophene-3-carbonyl Chloride Thiophene-3-carbonyl Chloride

: The X-ray structure of the title compound has been determined for the ﬁrst time. It shows the ring ﬂip disorder common among thiophene-3-carbonyl derivatives and the occurrence of this phenomenon in the structures of such compounds is discussed. its X-ray structure has not so far been reported, perhaps due to its relatively low melting point of 53–54 ◦ C and the consequent difﬁculty in obtaining suitable crystals. In view of several recent reports of “ring ﬂip disorder” in the structures of thiophene-3-carbonyl derivatives (Figure 1), we were interested to see whether this compound would exhibit the same phenomenon. A sample of the compound was available from our previous work [2], and it showed spectroscopic data in agreement with published values [3]. We report here its X-ray structure, which does show ring ﬂip disorder, and survey the recent research activity in this area. Abstract: The X-ray structure of the title compound has been determined for the first time. It shows the ring flip disorder common among thiophene-3-carbonyl derivatives and the occurrence of this phenomenon in the structures of such compounds is discussed.
Who are midwives and traditional birth attendants according to the users in the rural area?

Background: Skilled traditional birth attendants as non-health workers (paraji) were risk factors for the incidence of maternal and perinatal mortality. Although the government has provided a birth insurance, rural communities still choose traditional birth attendant as their birth helper. The study aims at investigating women’s perceptions and experiences of birth helped by midwife and traditional birth attendant. Method: The qualitative study with phenomenological approach were conducted through in-depth interviews using an interview guide. Data collection was conducted from June to July 2013 at Gajah Mekar Village, Kutawaringin District, Bandung Regency. Sampling was conductedusing purposive sampling technique. Total participants involved in this study were 12 women. Results: This study finds out that childbirth women distinguish maternity services provided by midwives and traditional birth attendants according to ages and appearances, beliefs/cultures, place of having birth, economic, delivery assistance, psychological and physical needs, post-natal care, and the danger/safety in childbirth. Conclusion: Strong culture in rural communities becomes an obstacle to equitable health care distribution. The government and related education institutions should collaborate in order to improve and enhance the quality of midwives and their services, so that birth assistances by traditional birth attendants can be suppressed.