Miracle-dz/UniFAR-FTUs huggingface dataset:
TAGGEDH 1 RETROSPECTIVE ANALYSIS OF THE IMPACT OF THE CORONAVIRUS DISEASE 2019 PANDEMIC ON HEALTH CARE WORKERS IN A TERTIARY HOSPITAL IN TURKEY TAGGEDEND

Introduction: Several vaccines have been developed and approved for use against severe acute respiratory syndrome coronavirus-2; however, the use of personal protective equipment remains important owing to the lack of effective specific treatment and whole community immunity. Hydroxychloroquine sulfate was a treatment option in the early days of the pandemic; however, it was subsequently removed owing to a lack of evidence as an effective treatment. We aimed to evaluate the testing and infection characteristics of coronavirus disease 2019 among health care personnel and determine the effectiveness of prophylactic hydroxychloroquine sulfate use to prevent transmission. Methods: This retrospective observational study was conducted between May 1 and September 30, 2020. The health care personnel included in the study were physicians, nurses, and paraprofessional support personnel. The health records of health care personnel who had been tested for severe acute respiratory syndrome coronavirus-2 using polymerase chain reaction were retrospectively analyzed. Results: In total, 508 health care personnel were included in the study. A total of 152 (29.9%) health care personnel were diagnosed with coronavirus disease 2019. The positive
The role of COMT gene Val108/158Met polymorphism in suicidal behavior: systematic review and updated meta-analysis

Background: It is accepted that there is a genetic factor that influences the risk of suicidal behavior. The catechol-O-methyltransferase ( COMT ) gene, especially the Val108/158Met polymorphism, has been associated with suicide; however, no conclusive outcome has been attained. Therefore, the aim of the present study was to assess the role of COMT Val108/158Met in suicidal behavior throughout an updated meta-analysis. Methods: We performed an online search using PubMed and Web of Science (up to March 2017). Our systematic review included case-control studies of individuals who attempted suicide and completed suicide. We tested allelic, homozygous, heterozygous, dominant, and recessive inheritance models. The meta-analysis was performed in accordance with the statement of Preferred Reporting Items for Systematic Reviews and Meta-Analyses. Results: The meta-analysis comprised 17 studies, which included 3,282 cases and 3,774 controls, and showed that when evaluating the overall population, the Val108/158Met polymorphism of COMT was not associated with suicidal behavior in any of the inheritance models; however, the subanalyses showed that this polymorphism exhibits a risk factor in males and a protective effect in females. Additionally, it conveyed a risk factor in Asian populations when using the allelic (OR 1.25; CI: 1.04–1.51) and recessive models (OR 1.32; CI: 1.03–1.68). Conclusion: Our updated meta-analysis suggests a possible association between COMT Val108/158Met and suicidal behavior in Asian populations. However, in view of the small number of studies, these results should be considered exploratory. We recommend that more studies be performed with larger samples.
Pharmacogenomics Study of Thiazide Diuretics and QT Interval in Multi-Ethnic Populations: The Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE)

Thiazide diuretics, commonly used antihypertensives, may cause QT interval (QT) prolongation, a risk factor for highly fatal and difficult to predict ventricular arrhythmias. We examined whether common SNPs modified the association between thiazide use and QT or its component parts (QRS interval, JT interval) by performing ancestry-specific, trans-ethnic, and cross-phenotype genomewide analyses of European (66%), African American (15%), and Hispanic (19%) populations (N=78,199), leveraging longitudinal data, incorporating corrected standard errors to account for underestimation of interaction estimate variances and evaluating evidence for pathway enrichment. Although no loci achieved genome-wide significance (P<5×10 −8 ), we found suggestive evidence (P<5×10 −6 ) for SNPs modifying the thiazide-QT association at 22 loci, including ion transport loci (e.g. NELL1, KCNQ3). The biologic plausibility of our suggestive results and simulations demonstrating modest power to detect interaction effects at genome-wide significant levels indicate that larger studies and innovative statistical methods are warranted in future efforts evaluating thiazide-SNP interactions.
Plastin increases cortical connectivity to facilitate robust polarization and timely cytokinesis

50% of embryos died during development. Moreover, mathe-matical modeling showed that an optimal amount of bundling agents enhanced the ability of a network to contract. We propose that by increasing the connectivity of the F-actin meshwork, plastin enables the cortex to generate stronger and more coordinated forces to accomplish cellular morphogenesis.
Optimal choice of word length when comparing two Markov sequences using a 2-statistic: supplementary materials

*Correspondence: fsun@usc.edu 1Centre for Computational Systems Biology, School of Mathematical Sciences, Fudan University , Shanghai, China 2Molecular and Computational Biology Program, University of Southern California, Los Angeles, California, USA Full list of author information is available at the end of the article 1 Appendix 1.1 Proof of Theorem 1 Let r1 and r2 (r1 ≤ r2) be the orders of sequences A1 and A2, respectively. If k < r2 + 1, even under the null hypothesis that the two sequences are from the same MC, the statistic Sk is large and does not follow a χ-distribution. For a given type I error α, the threshold for rejecting the null hypothesis should be very big. Therefore, the power of Sk under the alternative hypothesis should be low. When k ≥ r2 + 1, Sk will be χ-distributed with Ck−1(C − 1) degrees of freedom under the null hypothesis, where C is the size of the alphabet. Under the alternative hypothesis, Sk will have a non-central χ-distribution with non-centrality parameter that can be computed as follows. Without loss of generality, we assume that the sequences have the same length L. Note from the law of large numbers for MCs [1, 2],
ACE gene polymorphism is associated with COPD and COPD with pulmonary hypertension: a meta-analysis

Purpose Angiotensin-converting enzyme (ACE) gene I/D polymorphism has been studied in relation to the susceptibility to COPD and COPD with pulmonary hypertension (PH) with inconclusive results. We performed the first comprehensive meta-analysis to evaluate accurately the association between the ACE gene polymorphism and the risk of COPD. Methods Data were analyzed using odds ratios (ORs) and the corresponding 95% CIs to measure the strength of the models. Subgroup analyses were conducted by ethnicity and complication which referred to PH. Results In total, 15 studies (2,635 participants) were included in our study, of which four studies (288 participants) were for PH subgroup. The overall analysis results indicated that the ACE gene polymorphism was not associated with COPD susceptibility in all gene models. However, the ethnic subgroup analysis results indicated that ACE gene polymorphism was associated with Asians’ susceptibility to COPD (DD+DI vs II, OR=1.47, P=0.019, 95% CI: 1.07–2.02). Further, the overall results of the present study detected no statistical significance between ACE gene polymorphism and the risk of COPD with PH, but the homozygote variant (DD) increased the risk of PH in Asian COPD patients (DD vs ID+II, OR=2.05, P=0.05, 95% CI: 1.00–4.19). Conclusion The current study suggests that ACE polymorphism, particularly the homozygote variant (DD), might contribute to the risk of COPD and COPD with PH among Asians. Further studies with larger sample size and more ethnicities are expected to be conducted in the future to validate the results.
Field guide to the birds of Western Africa

This new field guide uses all of the plates from Birds of Western Africa, with a concise, authoritative text on facing pages, to create a conveniently-sized, lightweight field reference covering all 1285 species found in the region. The book also has an updated colour distribution map for each species, conveniently placed on interleaved pages within the colour plates. A number of new images have been painted for this new field guide and several of the plates have been replaced. This is the first comprehensive field guide to cover the birds of this exciting region, and will enable birders to identify any species found in any of the countries covered. Birds of Western Africa (Helm, 2001) was the first single-volume guide to cover all species of this region, which comprises all countries from Senegal and southern Mauritania east to Chad and the Central African Republic and south to Congo.
Piperacillin/tazobactam-resistant, cephalosporin-susceptible Escherichia coli bloodstream infections are driven by multiple acquisition of resistance across diverse sequence types

Resistance to piperacillin/tazobactam (TZP) in Escherichia coli has predominantly been associated with mechanisms that confer resistance to third-generation cephalosporins. Recent reports have identified E. coli strains with phenotypic resistance to piperacillin/tazobactam but susceptibility to third-generation cephalosporins (TZP-R/3GC-S). In this study we sought to determine the genetic diversity of this phenotype in E. coli (n=58) isolated between 2014–2017 at a single tertiary hospital in Liverpool, UK, as well as the associated resistance mechanisms. We compare our findings to a UK-wide collection of invasive E. coli isolates (n=1509) with publicly available phenotypic and genotypic data. These data sets included the TZP-R/3GC-S phenotype (n=68), and piperacillin/tazobactam and third-generation cephalosporin-susceptible (TZP-S/3GC-S, n=1271) phenotypes. The TZP-R/3GC-S phenotype was displayed in a broad range of sequence types, which was mirrored in the same phenotype from the UK-wide collection, and the overall diversity of invasive E. coli isolates. The TZP-R/3GC-S isolates contained a diverse range of plasmids, indicating multiple acquisition events of TZP resistance mechanisms rather than clonal expansion of a particular plasmid or sequence type. The putative resistance mechanisms were equally diverse, including hyperproduction of TEM-1, either via strong promoters or gene amplification, carriage of inhibitor-resistant β-lactamases, and an S133G bla CTX-M-15 mutation detected for the first time in clinical isolates. Several of these mechanisms were present at a lower abundance in the TZP-S/3GC-S isolates from the UK-wide collection, but without the associated phenotypic resistance to TZP. Eleven (19%) of the isolates had no putative mechanism identified from the genomic data. Our findings highlight the complexity of this cryptic phenotype and the need for continued phenotypic monitoring, as well as further investigation to improve detection and prediction of the TZP-R/3GC-S phenotype from genomic data.
Using agent-based modelling to evaluate mitigation measures for moose-vehicle collisions

In northern countries, moose vehicle collisions (MVCs) are often associated with the presence of salt pools near highways. Mitigation measures such as designing compensation salt pools further away from the highway and building fences along highways can be used. Fences are very efficient in reducing MVCs, but wildlife passages are required in order to increase highway permeability. Agent-based modelling (ABM) was used to study the effect on moose movement behaviour near highways of roadside salt pool removal and displacement and to estimate the required density of underpasses in fenced areas. ABM was applied to Highway 175 (Quebec) where an extensive telemetry dataset on moose movement was available. The movement rules were based on cover and food quality in GIS forest polygons. Model moose had salt pool spatial memory (SPSM) and, in most cases, road avoidance (RA) behaviour, the opposing effect of which on the number of road crossings was investigated. Completely removing roadside salt pools with no compensation salt pools resulted in the highest highway crossing reductions (by 79%). A conceptual framework was also designed for investigating the movement of moose along fences using ABM. The current spacing of wildlife passages along Highway 175 is markedly larger than the recommended allometric spacing (i.e. based on home range size). The objective was to assess the impact of wildlife crossing distances on highway permeability. Because of the lack of telemetry data near fences, probabilistic and fuzzy-logic approaches were proposed to determine movement rules of the model moose. Once the model is implemented, it is anticipated that permeability will increase with decreasing distances between passages, and that a plateau may be observed once the allometric distance is reached.
Treatment outcomes of using inhalation sedation for comprehensive dental care within the hospital dental service by utilising the Indicator of Sedation Need (IOSN) assessment tool

Background: Dental fear and anxiety are common encounters in paediatric dentistry. Therefore, it is important to understand the causes and types of dental anxiety in order to implement the appropriate behaviour management strategies so that high quality dental care could be delivered and disruptive behaviour is minimised. Some dentally anxious individuals have reported that the provision of a form for sedation would facilitate their dental treatment. Therefore assessing the need for sedation would be beneficial. Aim: To assess the treatment outcomes of using inhalation sedation for comprehensive dental care within the hospital dental service by utilising a modified version of the Indicator of Sedation Need (IOSN) assessment tool. Materials and Methods: The present study was carried out in two phases: Retrospective Phase – A study of the treatment outcomes when using inhalation sedation for comprehensive dental care within the hospital dental service. Prospective Phase - A study investigating the outcomes of dental treatment of patients referred to the sedation unit at the LDI when the paediatric version of the indicator of sedation need (p-IOSN) was utilised. Results: Retrospective Phase: the records of 453 patients (213 males and 240 females) were evaluated. Mean age was 10.30 (SD = 2.95) years. Treatment was completed successfully in 63.6% of the cases. Results revealed that age below 10 years was significantly associated with the outcome that “treatment abandoned in sedation unit and child referred to receive treatment under general anaesthesia (GA)”. No significant association was found between gender and treatment outcome. Prospective Phase: Forty patients (16 males and 24 females) of mean age 9.99 (SD = 3.14) years were followed up to ascertain treatment outcomes when the p-IOSN was used. Of the total of 40 children included in the prospective study, 20 (50%) scored 6 on p-IOSN. Treatment completion rate was 72.5%. Although major differences existed between age and treatment outcomes, they failed to achieve statistical significance. No significant association was found between gender and p-IOSN of any score with any treatment outcome. Conclusions: p-IOSN is a useful tool that can be utilised to predict child patients who would benefit from sedation for their dental treatment. However, the p-IOSN is still in the investigational stages and further research is required prior to its use on the clinical grounds.
Atrial Fibrillation Ablation: The State of the Art based on the Venicechart International Consensus Document

Preface, vii List of contributors, ix VeniceChart task force composition, xxxiii List of abbreviations, xxxvii 1 Anatomy of structures relevant to atrial fibrillation ablation, 1 2 Pathophysiology of atrial fibrillation, 20 3 Techniques and technologies for atrial fibrillation catheter ablation, 35 4 Endpoints of catheter ablation for atrial fibrillation, 61 5 Patient management pre-, during-, and postablation, 70 6 Periprocedural and long-term anticoagulation, 77 7 Periprocedural and late complications, 85 8 Short- and long-term efficacy of catheter ablation procedures for atrial fibrillation, 118 9 Indications to atrial fibrillation ablation and cost-effectiveness, 127 10 Clinical trials on atrial fibrillation/future perspectives, 137 11 Surgical approach/ablation, 161 12 Hospital equipment and facilities, personnel, training requirements, and competences, 176 Index, 184
Informal Institutions and Rural Development in China

Foreword Carsten Herrmann-Pillath Preface Tony Saich Preface Hiranya D. Dias 1. Introduction: background of the research 2. Village trust, guanxi community and IVWC governance: an interdisciplinary approach to informal institutional analysis in rural China 3. Indigenous conceptions of networks 4. Selection of research area 5. Village trust and Bidding ROSCAs 6. Guanxi community and people's mobility 7. Guanxi community and TVEs development in China 8. Institution of 'integrating village with company' (IVWC) and rural community development 9. Conclusion: integration of tradition and modernity - towards understanding institutional arrangements in China's modernization Glossary of Chinese terms Notes Bibliography Index'
Activity-dependent trafficking of lysosomes in dendrites and dendritic spines

acid–type glutamate receptors. Strikingly, lysosomes traffic to dendritic spines in an activity-dependent manner and can be recruited to individual spines in response to local activation. These data indicate the position of lysosomes is regulated by synaptic activity and thus plays an instructive role in the turnover of synaptic membrane proteins.
Mining Genetic Epidemiology Data with Bayesian Networks Application to APOE Gene Variation and Plasma Lipid Levels

There is a critical need for data-mining methods that can identify SNPs that predict among individual variation in a phenotype of interest and reverse-engineer the biological network of relationships between SNPs, phenotypes, and other factors. This problem is both challenging and important in light of the large number of SNPs in many genes of interest and across the human genome. A potentially fruitful form of exploratory data analysis is the Bayesian or Belief network. A Bayesian or Belief network provides an analytic approach for identifying robust predictors of among-individual variation in a disease endpoints or risk factor levels. We have applied Belief networks to SNP variation in the human APOE gene and plasma apolipoprotein E levels from two samples: 702 African-Americans from Jackson, MS, and 854 non-Hispanic whites from Rochester, MN. Twenty variable sites in the APOE gene were genotyped in both samples. In Jackson, MS, SNPs 4036 and 4075 were identified to influence plasma apoE levels. In Rochester, MN, SNPs 3937 and 4075 were identified to influence plasma apoE levels. All three SNPs had been previously implicated in affecting measures of lipid and lipoprotein metabolism. Like all data-mining methods, Belief networks are meant to complement traditional hypothesis-driven methods of data analysis. These results document the utility of a Belief network approach for mining large scale genotype-phenotype association data.
The proapoptotic, HIV protease generated Casp8p41 when bound and inactivated 1 by Bcl2, is degraded by the proteasome

22 HIV protease is known to cause cell death which is dependent upon cleavage of 23 procaspase 8. HIV protease cleavage of procaspase 8 generates Casp8p41 which 24 directly binds Bak with nanomolar affinity causing Bak activation and consequent cell 25 death. Casp8p41 can also bind Bcl2 with nanomolar affinity in which case cell death is 26 averted. Central memory CD4 T cells express high levels of Bcl2 possibly explaining 27 why these cells do not die when they reactivate HIV. Here we determine that the 28 Casp8p41:Bcl2 complex is polyubiquitinated and degraded by the proteasome. 29 Ixazomib, a proteasome inhibitor in clinical use, blocks this pathway – increasing the 30 abundance of Casp8p41 and causing more cells to die in a Casp8p41 dependent 31 manner. 34 35 blocks degradation of increasing 36 Casp8p41
Bourantas and Serruys TAVR : Past and Present 1039

Severe symptomatic aortic stenosis (AS) is the most frequent valvular heart disease in elderly, and it is associated with poor outcomes if left untreated. Surgical aortic valve replacement (SAVR) is the traditional treatment and seems to improve symptoms, quality of life, and prolong survival. However, a substantial number of patients (30%–40%) is deemed unsuitable for SAVR because of the multiple comorbidities that they have, which raise considerably the periprocedural risk. In 2002, Cribier et al demonstrated for the first time the feasibility of a percutaneous valve implantation in a patient with AS, providing a promising less invasive alternative treatment for valvular heart disease. Since then, an effort was made to address the initial limitations of transcatheter aortic valve replacement (TAVR) technology and broaden its applications. New developments in valves and TAVR enabling devices have reduced the risk of complications, simplified the procedure, and allowed the treatment of more complex anatomies, while evidence from registries and randomized control trials has provided robust data about the efficacy of this therapy which today is regarded as the treatment of choice in inoperable patients and selected high-risk populations. In this review article, we trace the history of TAVR, describe the first studies in animal models and humans, present the recent technological advances, and discuss the current limitations and future perspectives in the field.
Qualidade de água no cultivo de camarão-da-amazônia Macrobrachium amazonicum em sistema fechado de recirculação.

A aquicultura vem demonstrando seu enorme potencial e capacidade de rapido desenvolvimento no Brasil e no mundo. Dentre seus diversos setores, a carcinicultura de agua doce e um dos que tem apresentado maior crescimento a nivel global. Assim, pesquisas visando aprimorar a tecnologia para criacao de camaroes em sistemas de recirculacao com o aproveitamento de agua sao importantes. E necessario o uso de sistemas simples, baratos e eficientes que podem ser utilizados nos laboratorios ou por pequenos produtores, que poderao tornar-se autossuficientes. Muitas pesquisas tem sido realizadas a fim de buscar metodologias para se desenvolver uma producao sustentavel, ou seja, lucrativa e com baixo impacto ambiental. Nesse contexto, o presente estudo buscou analisar a qualidade da agua em um sistema de recirculacao com juvenis de camarao-da-amazonia. Foram utilizadas 12 caixas com capacidade de 60 litros, e povoadas com 120 animais, com peso e tamanho medio, respectivamente de 1,0 g e 44 mm, acopladas a um filtro biologico, nas quais foram verificados os paramentos de qualidade de agua. Os resultados mostraram que os parâmetros variaram entre 28 °C e 29 °C para temperatura, pH entre 6,0 e 8,5, condutividade eletrica 0,079 mS/cm a 0,475 mS/cm, turbidez 0 NTU a 9 NTU, a amonia total ficou abaixo de 1,0 mg/litro e oferta de oxigenio dissolvido ficou na faixa de 6,1 mg/L a 7,0 mg/L. O sistema manteve a temperatura, pH, condutividade eletrica, oxigenio dissolvido e turbidez e niveis de amonia em constantes e aceitaveis durante os 60 dias de experimento. Os dados obtidos indicam que o sistema de recirculacao adotado foi eficiente na manutencao da qualidade da agua na fase de engorda do camarao-da-amazonia em escala laboratorial, sendo necessario sua validacao em âmbito comercial.