Miracle-dz/UniFAR-FTUs huggingface dataset:
Epidemiology, risk factors, and outcomes associated with cytomegalovirus in adult kidney transplant recipients: A systematic literature review of real‐world evidence

Kidney transplant recipients (KTRs) have increased risk for cytomegalovirus (CMV) infection/disease given the necessity of drug‐induced immunosuppression. A comprehensive review of published literature reporting real‐world data on prevention strategies utilized and associated CMV burden outcomes is limited. Such data could help inform future clinical practice and identify unmet needs in CMV management. We conducted a systematic review of observational studies published in Medline or EMBASE from January 2008 to November 2018 to identify current real‐world CMV management approaches, CMV infection/disease risk factors, and outcomes associated with CMV infection. Descriptive statistics and pooled quantitative analyses were conducted. From 1608 records screened, 86 citations, including 69 803 adult KTR, were included. Prophylaxis and preemptive therapy (PET) were predominant approaches among D+/R‐ and R + CMV serostatus transplants, respectively. Valganciclovir and ganciclovir were frequently utilized across CMV risk strata. Despite prevention approaches, approximately one‐fourth of KTR developed CMV infection. Age and D+/R‐ CMV serostatus were consistent risk factors for CMV infection/disease. CMV infection/disease was associated with increased mortality and graft loss. CMV was similarly associated with acute rejection (AR) risk, but with high heterogeneity among studies. Limited data were available on CMV and opportunistic infections (OIs) risk. CMV remains a significant issue. New strategies may be needed to optimize CMV management.
Effect of Oral Nutritional Supplementation on the Prognostic Nutritional Index in Gastric Cancer Patients

Abstract This prospective study was undertaken to investigate whether preoperative oral nutritional supplementation (ONS) would increase the prognostic nutritional index (PNI) in gastric cancer patients undergoing gastrectomy. Before surgery for resectable gastric cancer, Racol® NF (Otsuka Pharmaceutical Factory, Japan) was administered orally at a recommended dose of 600 kcal/600 ml per day to patients with a PNI of <48. The primary endpoint was the change in the PNI, which was calculated as 10 × serum albumin (g/dl) + 0.005 × total lymphocyte count (per mm3). Forty-six patients received Racol® NF. The mean PNI at baseline and before surgery was 44 ± 3.9 and 43 ± 4.4, respectively (p = 0.049). The mean serum albumin level was significantly decreased after the administration of Racol® NF (p = 0.001), while the mean total lymphocyte count (p = 0.001) and body weight (p = 0.004) were significantly increased. The mean daily intake and duration of Racol® NF administration were 340 ml and 22.6 day, respectively. Adverse events during the administration of Racol® NF were observed in 12 (26.1%) patients. The present study indicated that preoperative ONS did not increase the PNI in gastric cancer patients with low PNI values.
Next Generation Health Claims Based on Resilience: The Example of Whole-Grain Wheat

Health claims on foods are a way of informing consumers about the health benefits of a food product. Traditionally, these claims are based on scientific evaluation of markers originating from a pharmacological view on health. About a decade ago, the definition of health has been rephrased to ‘the ability to adapt’ that opened up the possibility for a next generation of health claims based on a new way of quantifying health by evaluating resilience. Here, we would like to introduce an opportunity for future scientific substantiation of health claims on food products by using whole-grain wheat as an example. Characterization of the individual whole wheat grain food product or whole wheat flour would probably be considered as sufficiently characterized by the European Food Safety Authority, while the food category whole grain is not specific enough. Meta-analysis provides the scientific evidence that long-term whole-grain wheat consumption is beneficial for health, although results from single ‘gold standard’ efficacy studies are not always straight forward based on classic measurement methods. Future studies may want to underpin the scientific argumentation that long-term whole grain wheat consumption improves resilience, by evaluating the disruption and rate of a selected panel of blood markers in response to a standardized oral protein glucose lipid tolerance test and aggregated into biomarkers with substantiated physiological benefits, to make a next-generation health claim for whole-grain wheat achievable in the near future.
Independent Components of EEG Activity Correlating with Emotional State

Among brain-computer interface studies, electroencephalography (EEG)-based emotion recognition is receiving attention and some studies have performed regression analyses to recognize small-scale emotional changes; however, effective brain regions in emotion regression analyses have not been identified yet. Accordingly, this study sought to identify neural activities correlating with emotional states in the source space. We employed independent component analysis, followed by a source localization method, to obtain distinct neural activities from EEG signals. After the identification of seven independent component (IC) clusters in a k-means clustering analysis, group-level regression analyses using frequency band power of the ICs were performed based on Russell’s valence–arousal model. As a result, in the regression of the valence level, an IC cluster located in the cuneus predicted both high- and low-valence states and two other IC clusters located in the left precentral gyrus and the precuneus predicted the low-valence state. In the regression of the arousal level, the IC cluster located in the cuneus predicted both high- and low-arousal states and two posterior IC clusters located in the cingulate gyrus and the precuneus predicted the high-arousal state. In this proof-of-concept study, we revealed neural activities correlating with specific emotional states across participants, despite individual differences in emotional processing.
A Functional Genomic Screen Identifies the Deubiquitinase USP11 as a Novel Transcriptional Regulator of ERα in Breast Cancer

A newly identified role for USP11 in ERα transcriptional activity represents a novel mechanism of ERα regulation and a pathway to be exploited for the management of ER-positive breast cancer. Approximately 70% of breast cancers express estrogen receptor α (ERα) and depend on this key transcriptional regulator for proliferation and differentiation. While patients with this disease can be treated with targeted antiendocrine agents, drug resistance remains a significant issue, with almost half of patients ultimately relapsing. Elucidating the mechanisms that control ERα function may further our understanding of breast carcinogenesis and reveal new therapeutic opportunities. Here, we investigated the role of deubiquitinases (DUB) in regulating ERα in breast cancer. An RNAi loss-of-function screen in breast cancer cells targeting all DUBs identified USP11 as a regulator of ERα transcriptional activity, which was further validated by assessment of direct transcriptional targets of ERα. USP11 expression was induced by estradiol, an effect that was blocked by tamoxifen and not observed in ERα-negative cells. Mass spectrometry revealed a significant change to the proteome and ubiquitinome in USP11-knockdown (KD) cells in the presence of estradiol. RNA sequencing in LCC1 USP11-KD cells revealed significant suppression of cell-cycle–associated and ERα target genes, phenotypes that were not observed in LCC9 USP11-KD, antiendocrine-resistant cells. In a breast cancer patient cohort coupled with in silico analysis of publicly available cohorts, high expression of USP11 was significantly associated with poor survival in ERα-positive (ERα+) patients. Overall, this study highlights a novel role for USP11 in the regulation of ERα activity, where USP11 may represent a prognostic marker in ERα+ breast cancer. Significance: A newly identified role for USP11 in ERα transcriptional activity represents a novel mechanism of ERα regulation and a pathway to be exploited for the management of ER-positive breast cancer.
Can economic forces cause ecological chaos ? The case of the northern California Dungeness crab fishery

Unpredictable, deviation amplifying dynamics known as chaos emerge from simple models of biological populations as certain parameters reach critical values (May 1974). Although all ecological systems contain the necessary ingredients for chaotic dynamics positive feedback self-replication and inertia in their negative feedback (control) processes they rarely seem to exhibit chaotic behavior (Hassell et al. 1976, Thomas et al. 1980, Berryman and Millstein 1989, Turchin 1991, Berryman unpubl.). It is possible to precipitate chaos in natural populations, however, by increasing the reproductive rates of the organisms or the inertia of negative feedback processes (Berryman and Millstein 1989). Chaotic dynamics emerge from models of biological populations through a cascade of bifurcations; from stable fixed points, through periodic cycles of increasing amplitude and complexity, to aperiodic chaotic orbits (May 1974). Regular periodic cycles, therefore, can be considered as harbingers of chaos. Cyclical dynamics have been observed in catch records of Dungeness crab, Cancer magister, from the northern Californian fishery (Fig. 1). Several hypotheses have been proposed to explain these cycles, including external forces such as wind stress (Johnson et al. 1986), upwellings, sunspot activity, and water temperature, and internal feedback responses such as density-dependent egg and larval predation and cannibalism of young (reviewed by Hankin 1985). However, an alternative hypothesis is that the cycles were induced by the interaction of the crab population with the economics of the fishery. This hypothesis arose from a preliminary inductive or diagnostic examination of the crab harvest trajectory (Fig. 1). First observe that the partial autocorrelation function (Fig. 1, insert) has significant peaks at lags 1 and 2, suggesting that the system may be influenced by fast acting (lag 1) and delayed (lag 2) feedback. The effects of these two feedbacks can be discerned in the timetrajectory (Fig. 1), where we see; (1) a pattern of highfrequency, low-amplitude oscillation over the first 9 yr (1945-1953) and the 22nd to 26th yr (1966-1970), which seemed to fluctuate around a common mean of about 72x 105 kg (broken line K in Fig. 1), and (2) a pattern of low-frequency, high-amplitude oscillations, or cycles, over the 11th to 22nd (1955-1966) and 27th to 34th yr (1971-1978), which seemed to become more pronounced and to increase in amplitude with time. These patterns are even more obvious on the reproduction phase portrait (Fig. 2): Notice the tightly bounded oscillations around the equilibrium (R = 0) line near the
A Comparative Scanning Electron Microscopy Study on Antennal Sensilla of Trissolcus japonicus and Trissolcus plautiae, Egg Parasitoids of Stink Bugs (Pentatomidae)

Abstract Trissolcus japonicus (Hymenoptera: Scelionidae) and Trissolcus plautiae are solitary endoparasitoids in eggs of stink bugs (Hemiptera: Pentatomidae). These two closely related parasitoids differ in their degree of host specificity. With the aid of scanning electron microscopy, we examined the external morphology, distribution, and abundance of the antennal sensilla of sexes of both species to gain insights into the olfactory mechanism in relation to host selection behavior. Seven types of sensilla were recorded in both species: basiconica, trichodea, grooved-peg, sickle-shaped, chaetica, papillary, and campaniformium sensilla. Sexual dimorphism of antennal structures occurred in both species. Male antennae possessed one more flagellomere and a larger number of olfactory sickle-shaped sensilla than female antennae, indicating that sensilla may be involved in mate or host location. There was a peg gland on the fifth antennomere of male antennae. Compared with males, females had a higher number of trichodea sensilla as well as papillary sensilla, which were not found in males. These sensilla might be involved in host recognition and acceptance during the drumming behavior of both species. No qualitative differences were recorded between the species in antennal structure, or sensilla types or topographical arrangement. However, the abundance of key sensilla was significantly different between species. T. plautiae females and males had larger numbers of trichodea sensilla than those of T. japonicus. T. japonicus females possessed fewer and larger sickle-shaped sensilla compared with T. plautiae females. These differences may provide a morphological basis for understanding the process of host habitat location and recognition in these parasitoids.
Patient-adaptable intracranial pressure morphology analysis using a probabilistic model-based approach

Objective: We present a framework for analyzing the morphology of intracranial pressure (ICP). The analysis of ICP signals is challenging due to the non-linear and non-Gaussian characteristics of the signal dynamics, inevitable corruption by noise and artifacts, and variations in ICP pulse morphology among individuals with different neurological conditions. Existing frameworks make unrealistic assumptions regarding ICP dynamics and are not tuned for individual patients. Approach: We propose a dynamic Bayesian network for automated detection of three major ICP pulsatile components. The proposed model captures the non-linear and non-Gaussian dynamics of ICP morphology and further adapts to a patient as the individual’s ICP measurements are received. To make the approach more robust, we leverage evidence reversal and present an inference algorithm to obtain the posterior distribution over the locations of pulsatile components. Main results: We evaluate our approach on a dataset with over 700 h of recordings from 66 neurological patients, where the pulsatile components were annotated by prior studies. The algorithm obtains accuracies of 96.56%, 92.39%, and 94.04% for the detection of each pulsatile component in the test set, showing significant improvement over existing approaches. Significance: Continuous ICP monitoring is essential in guiding the treatment of neurological conditions such as traumatic brain injuries. An automated approach for ICP morphology analysis is a step towards enhancing patient care with minimal supervision. Compared to previous methods, our framework offers several advantages. It learns the parameters that model each patient’s ICP in an unsupervised manner, resulting in an accurate morphology analysis. The Bayesian model-based framework provides uncertainty estimates and reveals interesting facts about the ICP dynamics. The framework can readily be applied to replace existing morphological analysis methods and support the use of ICP pulse morphological features to aid the monitoring of pathophysiological changes of relevance to the care of patients with acute brain injuries.
Risk factors for mortality in critically ill patients with COVID‐19 in Huanggang, China: A single‐center multivariate pattern analysis

To date, the coronavirus disease 2019 (COVID‐19) has a worldwide distribution. Risk factors for mortality in critically ill patients, especially detailed self‐evaluation indicators and laboratory‐examination indicators, have not been well described. In this paper, a total of 192 critically ill patients (142 were discharged and 50 died in the hospital) with COVID‐19 were included. Self‐evaluation indicators including demographics, baseline characteristics, and symptoms and detailed lab‐examination indicators were extracted. Data were first compared between survivors and nonsurvivors. Multivariate pattern analysis (MVPA) was performed to identify possible risk factors for mortality of COVID‐19 patients. MVPA achieved a relatively high classification accuracy of 93% when using both self‐evaluation indicators and laboratory‐examination indicators. Several self‐evaluation factors related to COVID‐19 were highly associated with mortality, including age, duration (time from illness onset to admission), and the Barthel index (BI) score. When the duration, age increased by 1 day, 1 year, BI decreased by 1 point, the mortality increased by 3.6%, 2.4%, and 0.9% respectively. Laboratory‐examination indicators including C‐reactive protein, white blood cell count, platelet count, fibrin degradation products, oxygenation index, lymphocyte count, and d‐dimer were also risk factors. Among them, duration was the strongest predictor of all‐cause mortality. Several self‐evaluation indicators that can simply be obtained by questionnaires and without clinical examination were the risk factors of all‐cause mortality in critically ill COVID‐19 patients. The prediction model can be used by individuals to improve health awareness, and by clinicians to identify high‐risk individuals.
The diagnostic value of dual-phase SPECT/CT scintigraphy based on transport kinetics of 99mTc-sestamibi confirmed with histopathological findings in patients with secondary hyperparathyroidism - practical consideration.

BACKGROUND Dual phase 99mTc-sestamibi SPECT/CT preoperative parathyroid scintigraphy (PPS) is seldom discussed in terms of the transport kinetics of the tracer. OBJECTIVES To assess the relationship between the characteristic type of tracer transport in particular PPS and histopathological findings in patients with secondary hyperparathyroidism (sHPT). MATERIAL AND METHODS The study comprised 27 patients (13 females and 14 males) with sHPT. Based on tracer accumulation in early phase (EP) and delayed phase (DP), the following types of accumulation for PPS(+) lesions were identified: EP(-)/ DP(+) (type I), EP(+)/DP(+) (type II), EP(+)/DP(-) (type III). EP(-)/DP(-) (type IV) lesions constituted PPS(-) group invisible in SPECT/CT. Overall, 69 lesions 59 PPS(+) and 10 PPS(-) were evaluated histopathologically. RESULTS Among SPECT/CT PPS(+), types I, II and III occurred in 9 (15%), 49 (83%), and 1 (2%) lesions, respectively. The frequency of histopathological diagnosis of normal and abnormal (APG - adenoma or hyperplasia) parathyroid gland, as well as non-parathyroid (thyroid, lymph nodes, or fat) lesions differed significantly between type I, II, and III lesions (p = 0.036). APG histopathological diagnosis was significantly more frequent in lesions with type II uptake than in lesions with type I uptake (76% vs. 33%, p = 0.0197). Type II lesions had significantly higher odds for histopathological diagnosis of APG or NPG than type IV, PPS(-) lesions [odds ratio = 13.1 (95% CI: 2.75 to 63.27)]. CONCLUSIONS For SHP patients evaluated with SPECT/CT PPS accumulation type I is a weak premise for surgeon to find parathyroid pathology. Only persistent 99mTc-sestamibi accumulation in both phases - equivocal with accumulation type II - effectively differentiates parathyroid and non-parathyroid lesions as well as indicates with high probability the presence of adenoma or hyperplasia. Type III consistent with washout pattern is rare in sHPT.
Evaluation of Inhibitory Effects of Caffeine on Human Carcinoma Cells

Abstract One of the world's most consumed medications is caffeine which is available in the vast majority of beverages. Previously, some effects of caffeine have been evaluated including its inhibitory effect on cancer cells. But, the influence of caffeine on esophagus carcinoma squamous cells (CSC) and head and neck carcinoma cells still has not well understood. Herein, the relation between different amounts of caffeine with the proliferation rate of human esophagus carcinoma squamous cell line KYSE-30 as well as human head and neck carcinoma cell line HN5 was evaluated. Furthermore, concentrations of caffeine were adjusted and their effect on cells were studied. The inhibitory effects of caffeine on cells were measured using the conventional colorimetric MTT assay after 3 and 7 day of incubation. Our findings are suggested that caffeine has a significant inhibitory effect on both cell lines at the concentrations of 20, 50, and 70 milli-mol (mmol). The result shows that caffeine can prevent the proliferation of carcinoma cells and it is a perfect candidate for therapeutic applications.
Clinical, epidemiological, and molecular aspects of picornaviruses (entero, parecho) in acute gastroenteritis: A study from Pune (Maharashtra), Western India

Among enteric viruses, rotavirus A (RVA), norovirus (NoV), adenovirus, and astrovirus (AstV) are the major etiological agents associated in acute gastroenteritis. The present study highlights, clinical, epidemiological, and molecular aspects with respect to RVA, NoV, enterovirus (EV), and human parechovirus (HPeVs) in sporadic cases (n = 305) of acute gastroenteritis, Pune (Maharashtra), Western India. Detection of RVA was carried out by enzyme‐linked immunosorbent assay, NoV, EV, and HPeVs by reverse transcription PCR. Prevalence of 36.06%, 20.32%, 14.09%, 3.93%, respectively was observed for RVA, EV, HPeVs, and NoV along with coinfections. Infections occurred in children less than 2 years old, with peak infections within 12 months age. The disease severity in RV infections was found high (70.90%) with severe disease, followed by EV (62.9%), NoV (58.33%), and HPeV (44.58%). Predominant strains of RV G1P[8], G2P[4] types with unusual G9P[4], NoV Genogroup II of genotype 4 strains and multiple EV types with EV‐B species, E14 and E17 and two novel EV‐75, EV‐107 types were detected. Circulation of heterogeneous HPeV genotypes (HPeV1–5, 7, 8, 13, 14, 16) with predominance of HPeV‐1 was noticed. Changing trends in circulation of a rare HPeV‐2 genotype, with emerging and reemerging strains was noted. The study highlights association of RVA, NoV, EV, and HPeV and their mono‐infections, genotype distribution, and changing trends in acute gastroenteritis, and added more knowledge on rota and nonrota enteric viruses in acute gastroenteritis. More such studies in rota vaccinated era are required across the country, as Indian rotavirus vaccine has been implemented under the National Immunization program.
EFFECTS OF DIFFERENT SUBSTRATES ON YIELD OF OYSTER MUSHROOM (PLEUROTUS SAJOR - CAJU)

Oyster mushroom was cultivated on different substrates viz. wheat and paddy straw, bajara, maize, jowar, cotton, soybean stalks and their leaves and groundnut creepers with wheat and soybean straw (1:1), and groundnut creepers alone. Amongst the different substrates cotton stalks and leaves was found significantly higher in respect of number and weight of sporophores (5.12 g) as well as yield of sporophores (914 g/kg of dry straw). The other substrates gaveoptimum yield such as paddy straw (613 g/kg of dry straw) followed by soybean straw (557 g/kg of dry straw) and combination of soybean straw plus wheat straw 1:1 w/w (508 g/kg of straw). The lowest yield was observed in the treatment of groundnut creepers 258 g/kg of dry substrate.
Leaf mass per area, nitrogen content and photosynthetic carbon gain in Acer saccharum seedlings in contrasting forest light environments

Total daily photosynthetic photon flux density (PPFD) varied by two orders of magnitude across forest understorey, gap and clearing habitats for sugar maple (Acer saccharum) seedlings in south-western Wisconsin, USA. Area-based photosynthetic capacity (A max /area) was greater in clearing or gap than in understorey seedlings, but little photosynthetic acclimation was observed between gap and clearing seedlings. We observed significant correlations between A max and leaf nitrogen content (N) among seedling populations from the three habitats when expressed on an area basis, but not on a mass basis because of scaling of leaf mass per unit area (LMA) with N (.)