Miracle-dz/UniFAR-FTUs huggingface dataset:
Writing Quality Predictive Modeling: Integrating Register-Related Factors

The primary purpose of this study is to investigate the degree to which register knowledge, register-specific motivation, and diverse linguistic features are predictive of human judgment of writing quality in three registers—narrative, informative, and opinion. The secondary purpose is to compare the evaluation metrics of register-partitioned automated writing evaluation models in three conditions: (1) register-related factors alone, (2) linguistic features alone, and (3) the combination of these two. A total of 1006 essays (n = 327, 342, and 337 for informative, narrative, and opinion, respectively) written by 92 fourth- and fifth-graders were examined. A series of hierarchical linear regression analyses controlling for the effects of demographics were conducted to select the most useful features to capture text quality, scored by humans, in the three registers. These features were in turn entered into automated writing evaluation predictive models with tuning of the parameters in a tenfold cross-validation procedure. The average validity coefficients (i.e., quadratic-weighed kappa, Pearson correlation r, standardized mean score difference, score deviation analysis) were computed. The results demonstrate that (1) diverse feature sets are utilized to predict quality in the three registers, and (2) the combination of register-related factors and linguistic features increases the accuracy and validity of all human and automated scoring models, especially for the registers of informative and opinion writing. The findings from this study suggest that students’ register knowledge and register-specific motivation add additional predictive information when evaluating writing quality across registers beyond that afforded by linguistic features of the paper itself, whether using human scoring or automated evaluation. These findings have practical implications for educational practitioners and scholars in that they can help strengthen consideration of register-specific writing skills and cognitive and motivational forces that are essential components of effective writing instruction and assessment.
DETERMINANTS OF OPTIMAL CAPITAL STRUCTURE AND SPEED OF ADJUSTMENT: EMPIRICAL EVIDENCE FROM NSE LISTED MANUFACTURING COMPANIES IN INDIA

The combining of equity and debt funding by a corporation to finance its assets, overall operation, and expansion is referred to as capital structure. There are no uniform guidelines for the optimal debt-equity mix that have been carefully addressed in the academic literature to the suitable capital structure mix. Previous research on ownership and capital structure, including as agency theory, pecking order theory, and trade-off theory, identified these concerns. The trade-off theory explains the hypothesis of capital structure, which is the possibility that an organisation will choose how much debt fund and how much equity fund to utilise by adjusting the costs and benefits. The funding comes from three sources: reserves or retained earnings, long-term borrowing, and new equity. The strong foundation was developed by the Modigliani and Miller, due to which numerous theoretical frameworks were developed and these frameworks give boost to future theoretical research about capital structure. The profit maximization activism is concerned about responsible decisions in all things. In this way, managers or directors may decide firm's capital structure to seek after their own particular advantages rather than those of investors or debt holders.
Recent progress in Cetuximab-based treatment for Triple-NegativeBreast Cancer

This study verifies the preclinical therapeutic effect of YM-1 silencing BAG3 combined with cetuximab targeted atepidermal growth factor receptor (EGFR) on Triple-Negative Breast Cancer (TNBC ) cell lines both in vitro and invivo. TNBC is defined as a unique subtype of breast cancer that leads to an increase in patients with interval cancerswhich can be detected annually. In actual research, targeted molecular therapies are involved in the field because of theimmunological heterogeneity of TNBC. YM-1 has a potentially better inhibition target for EGFR instead of BAG3. Byreviewing some existing preclinical research and targeted treatment for TNBC, this study is to propose a novel treatmenttarget for TNBC based on cetuximab treatment.
The Effect of Sodium Content in Food on the appetite of the ObesePeople: A Research Proposal on Cognitive Diversity

Previous studies showed that people with obesity respond to high- or low-calorie foods differently from those withthe standard Body Mass Index (BMI). Nevertheless, as suggested by the previous paper, sodium might be a clue thatleads to high-calorie food intake, which then induces obesity. Also, the synergy between eating high-calorie food andhigh-sodium food was found to be one of the mechanisms that developed obesity. However, no study has been done toinvestigate the effect of sodium food on the appetite of people suffering from obesity. To find out this question, we willconduct behavior tests, including lexical decisions and visual stimulation, to determine whether the sodium componentin the food can be a way to define the food stimuli that develop eating addiction in obesity population. Besides, we willcompare which delivery of this kind of stimuli, through pictures or words, will affect the results more, if possible.
Effects of contextual constraints, work volition, and career adaptability on decent work conditions among young adult social workers: a moderated mediation model

ABSTRACT Using cross-sectional data collected from 974 young adult social workers aged 21–29 from three metropolitan cities in China, namely, Hong Kong, Shenzhen, and Guangzhou, this study examined the effects of contextual constraints, work volition, and career adaptability on decent work conditions and tests a moderated mediation model. Results showed that work volition mediated the relationship between contextual constraints and decent work conditions and that career adaptability moderated the link between work volition and decent work conditions. The indirect effect of contextual constraints on decent work conditions via work volition varied based on career adaptability, that is, the indirect effect was weaker for individuals with a higher level of career adaptability. The results of this study will inform the application and adaptation of the psychology of working theory with the lens of decent work to further promote the well-being and career development of young adult social workers.
Disfluencies in continuous speech in French: Prosodic parameters of filled pauses and vowel lengthening

This study examines prosodic parameters in two types of disfluencies, vowel lengthenings, and filled pauses. We analyzed approximately 2.5 hours of continuous speech representing 11 different speech genres, including prepared, semi-prepared, and unprepared speech. Mean fundamental frequency (f0) and pitch resets were analyzed to compare the prosodic correlates of disfluent (e.g., lengthenings, filled pauses) syllables with their surrounding fluent syllables as a function of the degree of speech preparation. The results show that the average fundamental frequency is lower in filled pauses and disfluent vowel lengthenings than in fluent speech. Furthermore, filled pauses are produced with a lower f0 than vowel lengthening. Larger pitch resets are observed between disfluent units and their preceding contexts, and both filled pauses and prolongations depend on the degree of preparation of the discourse. The duration of vowel lengthening tends to be longer than that of filled pauses.
Family firm performance: the effects of organizational culture and organizational social capital

PurposeThe goal of this paper is to examine the mediating role of organizational social capital between family firms' organizational culture, characterized by their group vs individual orientation and external vs internal orientation, and their performance.Design/methodology/approachA structural equation model is developed and tested in a sample of 176 US family firms recruited through Prolific Academic.FindingsThe authors show that group vs individual cultural orientation fosters bonding social capital, while external vs internal cultural orientation fosters bridging social capital. In turn, family firm performance is only enhanced by bridging social capital, not bonding social capital, which appears to have neutral to negative direct performance effects. Nevertheless, it is noteworthy that bonding social capital facilitates the establishment of bridging ties, leading to overall positive performance outcomes.Originality/valueThe understanding of how organizational culture influences family business heterogeneity and performance, along with the clarification of how bonding social capital fosters or hinders performance, provides novel insights for researchers and practitioners seeking to understand the complexities within the unique context of family businesses.
Analyse rétrospective des relations nappe-végétation de sous-bassins versants forestiers de la rivière Leyre

Dans les Landes de Gascogne, le fonctionnement de la nappe phreatique superficielle plio-quaternaire est tres liee au fonctionnement de la vegetation subjacente. Pour comprendre la variabilite a l'echelle du paysage de la productivite de ces forets, il est important de passer de l'echelle de la parcelle a celle du bassin versant. La mise en place d'un dispositif de suivi de type bassins versants jumeles a l'echelle de petits bassins versants forestiers situes dans le Massif Landais : les bassins versants du Tagon (Biganos) et du Bouron (Belin-Beliet) a permis le suivi hydrologique et piezometrique de la nappe plio-quaternaire. Le dispositif inclut une modification du couvert vegetal par l'occurrence de deux tempetes successives a 10 ans d'intervalle. La collecte de donnees cartographiques, numeriques et statistiques a permis une reconstitution de l'usage des terres et des classes d’âges des peuplements forestiers, pour la periode 1984- 2010 sur les deux bassins versants. Cette reconstitution a ainsi permis de retrouver l'evolution des stocks de carbone et de biomasse des peuplements pour les deux sites experimentaux et de quantifier l'impact d'une tempete sur l'organisation paysagere des peuplements (âge et variabilite). Le lien entre les forets de Pin maritime et la nappe phreatique plio-quaternaire a ete mis en evidence par : (1) l'etude de la croissance des arbres pour des sites ou la profondeur de la nappe etait contrastee, au travers d'une etude dendrologique et (2) l'analyse d'oscillations journalieres sur les series chronologiques des fluctuations demi-horaires du niveau phreatique, qui peuvent etre attribuees a l’evapotranspiration journaliere. La comprehension des liens entre variables hydroclimatiques et quantite de bois produite, i.e. largeur de cerne, de maniere retrospective, a permis d'identifier les facteurs de variabilite et les facteurs limitants pour chaque type de site, en lien avec la profondeur de la nappe superficielle. L’analyse des chroniques piezometriques a mis en lumiere l'importance des prelevements journaliers dans la vidange de l'aquifere. La derniere partie de ce travail pose les bases d'une future modelisation couplee vegetation-nappe pour le bassin versant du Bouron. La reconstitution spatiale du fonctionnement de la nappe phreatique a ete entreprise en regime stationnaire puis en regime dynamique avec le modele NEWSAM de l'Ecole des Mines de Paris. Les facteurs expliquant le fonctionnement de l'aquifere et les flux d'eau a l'echelle de la petite region sont identifies. L'effet de la recharge, issue du modele de vegetation pour le Pin maritime GRAECO, est en particulier teste, via une etude de sensibilite, en relation avec les differences de recharge induites par les differents types de couverts, et en particulier, l'âge des peuplements. Les points clefs a ameliorer sont identifies afin de perfectionner les modeles utilises, et de reproduire de facon realiste le fonctionnement de petits bassins versants dans la region.
Virtual screening of anticancer activity of chalcones and pyrazolines as potential EGFR, VEGFR, and cytochrome P450 inhibitors

Context: Metastatic breast cancer is still categorized as an incurable disease because all available therapies are palliative treatments to relieve symptoms and increase life expectancy. Our previous study showed that N-pyrazoline-derived compounds have the potential as an antiproliferative drug in cervical cancer cells line. Therefore, virtual screening is conducted in this study to predict the anticancer potential of several molecules (chalcone and pyrazoline derivatives) against breast cancer cells before in vitro testing. Aims: To screen potential anticancer compounds of chalcone and pyrazoline derivatives through in silico approach. Methods: In this study were carried out multiple virtual screening steps to predict drug-likeness, pharmacokinetic, toxicity, and interactions between drug candidates and receptors involved cell in proliferation (EGFR, PDB.id 7LGS), angiogenesis (VEGFR1, PDB.id 3HNG; VEGFR2, PDB.id 4AG8), and oxidative stress (cytochrome P450, PDB.id 3UA1). Results: Results revealed that pyrazolines A, A1, A2, B, C2, D, and M could potentially be anticancer agents since the molecules qualify Lipinski’s rule, are predicted to have good pharmacokinetics, are indicated as harmless, and exhibit the best binding affinity based on molecular docking analysis. Conclusions: The EGFR appears to be the main pathway targeted by pyrazoline derivates. Meanwhile, the ligand will go through the VEGFR1, VEGFR2, or P450 pathways when it successfully overcomes the binding obstacle. In addition, pyrazolines A, A1, A2, B, C2, D, and M need to be synthesized and evaluated the in vitro and in vivo anticancer activity.
Observed nonlinear site amplification of vertical ground motion in Taiwan

The objective of this study is to evaluate the possible reason for the observed nonlinear site amplification (NSA) of vertical ground motions in Taiwan. First, we observe that NSA generally occurs simultaneously in both the horizontal and vertical components of a ground-motion record and that the NSA levels are similar between these components. We also observe that most vertical peak ground acceleration (PGA) and vertical peak oscillator spectral acceleration (SA) responses for different periods occur during the shear wave (S-wave) window after S-wave arrival. The differences in the source, path, and site effects on PGA and SA responses occurring during the pressure wave (P-wave) and S-wave windows are evaluated individually through a regression analysis. We determine that NSA is observed only when PGA and SA responses occur during the S-wave window. This evidence demonstrates that the observed NSA of vertical ground motions in Taiwan may result from the hysteresis of the soil layer subjected to S-waves. This study provides physical evidence for the observed NSA of vertical ground motions in Taiwan.
Comparative ecology and taphonomy of spotted hyenas, humans, and wolves in Pleistocene Italy

In Late Pleistocene Italy, spotted hyenas competed in certain niche dimensions with wolves and in other dimensions with Paleolithic humans. Spotted hyenas of the Italian peninsula consumed essentially the same ungulate species as Paleolithic humans did, and both of these predators depended heavily on bone marrow. Wolves tended to consume more hillside-adapted ungulates in the same area and period, suggesting some spatial separation of the three predators according to topography. There is complete overlap in the prey age groups commonly harvested by spotted hyenas and wolves, but pronounced differences between this pair of predators and Paleolithic humans of the Middle and Upper Paleolithic periods ; from the narrow perspective of ungulate exploitation, Middle and Upper Paleolithic humans were quite similar. Taken together, there is good evidence for niche separation among the three ungulate predators during the Late Pleistocene in Italy. The intensity of bone transport to and modification at dens by hyenas varied greatly with circumstance and prey body size, indicating that prey size must be carefully controlled in comparisons of predator behavior. Populations of wolves and humans appear to have expanded toward the end of spotted hyenasʼ tenure on the Italian peninsula, and disappearance of the spotted hyenas from Eurasia may be best explained by rapid transformations of ecosystem structure associated with global warming after 13 KYA.
Effect of PD-1 Inhibitor on PI3K/AKT Pathway in Tumor Cell and TCell Activity in Non-small Cell lung Cancer (NSCLC)

Lung cancer is one of the most lethal cancers around the world and non-small cell lung cancer takes up about 85% ofthe cases. PD-1 inhibitor is an antibody used in immunotherapy to treat cancer. Previous studies have reported thatthe PD-1 inhibitor can block the PD-1/PD-L1 binding and help the immune system recognize and attack tumors. ThePI3K/AKT signaling pathway is an important target of the PD-1 downstream pathway. This paper studies the effects ofPD-1 inhibitor Pembrolizumab on the activation of the PI3K/AKT pathway in vivo. In this study, A549 cell line willbe used as the non-small cell lung cancer model. The immune-deficient mice will be injected with Keytruda, saline(negative control) or Taxol (positive control). Flow cytometry and Western Blot will be used to measure the activationof tumor cells and CD4 T cells. This paper investigates whether or not PD-1 inhibitor would effectively block thePI3K/AKT pathway and increase T cell proliferation. The result of this study will explore the blocking mechanism ofPembrolizumab on PI3K/AKT pathway. Future studies should focus on the acquired resistance caused by mutations andits effects on PD-1 inhibitor treatment with PI3K/AKT pathway activation as the biomarker.
Posterior sampling-based online learning for the stochastic shortest path model

We consider the problem of online reinforcement learning for the Stochastic Shortest Path (SSP) problem modeled as an unknown MDP with an absorbing state. We propose PSRL-SSP , a simple posterior sampling-based reinforcement learning algorithm for the SSP problem. The algorithm operates in epochs. At the beginning of each epoch, a sample is drawn from the posterior distribution on the unknown model dynamics, and the optimal policy with respect to the drawn sample is followed during that epoch. An epoch completes if either the number of visits to the goal state in the current epoch exceeds that of the previous epoch, or the number of visits to any of the state-action pairs is doubled. We establish a Bayesian regret bound of ˜ O ( B (cid:63) S √ AK ) , where B (cid:63) is an upper bound on the expected cost of the optimal policy, S is the size of the state space, A is the size of the action space, and K is the number of episodes. The al-gorithm only requires the knowledge of the prior distribution, and has no hyper-parameters to tune. It is the ﬁrst such posterior sampling algorithm and outperforms numerically previously proposed optimism-based algorithms.
Our Experience of Deep Sclerectomy at a Tertiary Center in the United Kingdom Over 14 Years

Background Deep sclerectomy (DS) is a non-penetrating surgical procedure for glaucoma, reducing the resistance to aqueous outflow and lowering intraocular pressure while maintaining a physiological barrier between the anterior chamber and the sub-scleral space. This offers a lower complication profile than penetrating procedures, though with less intraocular pressure (IOP) reduction. Methods We retrospectively reviewed the electronic record for all DS undertaken at our hospital (a tertiary care center) over 14 years, collecting data on demographics, diagnosis, IOP, visual acuity, complications, medications, and further procedures required. Results Eighty eyes of 69 patients underwent DS, with a mean follow-up period of 53.5 months. The mean pre-operative IOP was 23.55 mmHg (range 11-52, standard deviation 8.46); the mean final IOP was 13.61 mmHg (range 5-35, SD 4.73), with a mean reduction of 42.21%. The mean change in glaucoma medications was -1.64. 78.40% experienced a reduction in glaucoma treatment. Post-operatively, 43.80% had no complications; this improved to 85.0% when numerical hypotony and raised IOP without visual sequelae were excluded. Further procedures required included Nd:YAG goniopuncture (10%), bleb needling (13.75%) or revision (7.5%), iridectomy (3.75%), goniosynechiolysis (1.25%), and autologous blood injection (1.25%). Two eyes were converted to trabeculectomy peri-operatively, with seven overall (8.75%) requiring trabeculectomy over the course of follow-up. 3.75% underwent glaucoma drainage device implantation, and 3.75% underwent cyclodiode laser. Conclusion We have found DS to be a safe, effective procedure for selected patients where trabeculectomy has a high likelihood of failure or where a higher IOP can be tolerated.
ANALISIS PENGOLAHAN LIMBAH MEDIS PADAT PADA 2 (DUA) PUSKESMAS RAWAT INAP DAN 2 (DUA) PUSKESMAS NON RAWAT INAP DI KABUPATEN BANYUMAS TAHUN 2016

Pusat kesehatan masyarakat (puskesmas) merupakan salah satu unit pelayanan kesehatan yang dalam kegiatannya menghasilkan limbah medis maupun limbah non medis baik dalam bentuk padat maupun cair. Tujuan dari penelitian ini adalah untuk menganalisis sistem pengolahan limbah medis padat ada 2 (dua) Puskesmas Rawat Inap dan 2 (dua) Puskesmas Non rawat Inap di Kabupaten Banyumas.Metode penelitian yang digunakan adalah metode penelitian yang digunakan adalah metode penelitian deskriptif. Penelitian ini menggunakan pendekatan kualitatif. Proses pengolahan sampah yang di lakukan setiap puskesmas yang di teliti sama yaitu dari mulai penimbulan, pewadahan, pengumpulan, pengangkutan pengolahan dan pembuangan akhir sudah sama semua di setiap puskesmas sudah ada tempat sampah yang terpisah antar sampah medis dan non medis. Akan tetapi untuk plastik bewarna pewadahan belum dilaksanakan untuk Puskemas II Cilongok dan Puskesmas II Kembaran.Kesimpulan dari penitian ini adalah pengelolaan limbah medis padat pada Puskesmas I Sokaraja, Puskesmas I Cilongok, Puskesmas II Cilongok, dan Puskesmas II Kembaran dapat dikatakan sudah sesuai dengan pengelolaan limbah medis menurut Kepmenkes No 1428/MENKES/SK/XII/2006.Saran yang diberikan kepada Puskesmas di Kabupaten Banyumas memperbaiki pengelolaan limbah medis padat dan non medis khususnya untuk pelabelan tempat sampah, penggunaan kantong plastik bewarna, dan tempat penampungan yang harus ada.
Growth of potatoes for CELSS

This report summarizes research on the utilization of white potatoes (Solanum tuberosum L.) for space life support systems at the University of Wisconsin-Madison over the period of 1984 to 1993. At full maturity the tuber productivity was 37.5 gm(exp -2) d(exp -1), equating to a growing area requirement for one human (2800 kcal d(exp -1)) of 10.1 m(exp -2). A recirculating nutrient system using slanted trays produced best potato growth and tuber yields when a 2-3 cm layer of gravel or arcillite media was utilized. Potato production was close to maximum under lighting levels of 400 micromol m(exp -2) s(exp -1) of photosynthetic photo flux (PPF) for 24 hours or 800 micromol m(exp -2) s(exp -1) for 12 hours, alternating diurnal temperatures of 22 C and 14 C, relative humidity of 85 percent, and a carbon dioxide level of 1000 micromol m(exp -1). The range of effective concentrations of each separate nutrient is reported. The extensive studies with potatoes in this project have demonstrated that this crop has high productivity of nutritous tubers with a high harvest index in controlled environments, and can fulfill a significant portion of the energy and protein requirements for humans in space.