Miracle-dz/UniFAR-FTUs huggingface dataset:
Optimization of Lactobacillus acidophilus La-5, Feta Cheese Starters and Salt Content in Iranian Ultrafiltered Soft Cheese Formula

This work was carried out in collaboration among all authors. Author MAN performed all the experiments and wrote the first draft of the manuscript. Author MRE supervised the searches and provided the facilities for the use of pilot-plant UF system at membrane laboratory of Tehran University. Author AMS managed the literature searches and edited the manuscript analytically. Author KKD performed the statistical analysis, wrote the Taguchi design protocol and edited the manuscript statistically. All authors read and approved the final manuscript. ABSTRACT Aims: To optimize the process variables including: Lactobacillus acidophilus La-5, total starter (a mixture of mesophilic cheese starters (MCS) and thermophilic yoghurt starters (TYS), mesophilic cheese starter: thermophilic yoghurt of acidophilus La-5 ºC, multiple of variables on probiotic count morphologies of probiotic starters -1 bulgaricus La-5 viability. Conclusion: This study showed that Iranian ultrafiltered soft cheese has a probiotic potential to have 10 7 CFU.g -1 viable cell count of Lactobacillus acidophilus La-5 strain, when process variables optimized and this progress will contribute to develop a healthier foods.
Regulation of RhoA by STAT3 coordinates glial scar formation

molecular mechanisms which reactive astrocytes form glial scars and the molecular effectors of STAT3 in reactive astrocytes dynamics. underlying molecular mechanisms We to elucidate the role of STAT3 in controlling reactive astrocytes dynamics during glial scar formation by a classical migration study approach. Understanding how the transcription factor signal transducer and activator of transcription–3 (STAT3) controls glial scar formation may have important clinical implications. We show that astrocytic STAT3 is associated with greater amounts of secreted MMP2, a crucial protease in scar formation. Moreover, we report that STAT3 inhibits the small GTPase RhoA and thereby controls actomyosin tonus, adhesion turnover, and migration of reactive astrocytes, as well as corralling of leukocytes in vitro. The inhibition of RhoA by STAT3 involves ezrin, the phosphorylation of which is reduced in STAT3-CKO astrocytes. Reduction of phosphatase and tensin homologue (PTEN) levels in STAT3-CKO rescues reactive astrocytes dynamics in vitro. By specific targeting of lesion-proximal, reactive astrocytes in Nestin - Cre mice, we show that reduction of PTEN rescues glial scar formation in Nestin-Stat3 +/ − mice. These findings reveal novel intracellular signaling mechanisms underlying the contribution of reactive astrocyte dynamics to glial scar formation.
An experimental study to demonstrate the extents of reversible changes after withdrawal of allethrin based mosquito coil smoke exposure along with the possible protective role of vitamin C on induced testicular changes in male wistar Albino rats

: - This study was an attempt to delineate the effect of allethrin based mosquito coil exposure on male fertility of wistar albino rats. This also includes two months of discontinuation of exposure to know whether there is any reversibility of changes. We also studied the role of an antioxidant (Vitamin C) in ameliorating the effect caused by the coil.The animals in our study were randomized into four groups: group I served as control rats; group II, III and IV received mosquito coil smoke 8 hours a day, 7 days a week for 12 week. Group IV rats co-administered oral supplementation of Vit. C (20 mg/kg body weight) once in a day for the same time period while group III animals were further kept for 8 weeks without any exposure to demonstrate withdrawal effect. Mean testicular weight was maximum in Group IV(1.83±0.30 gm) followed by group I(1.56±0.19gms), group III(1.22±0.42 gms) and group II(0.64±0.09 gm). Mean sperm count ranged from 83.75±9.61 units in Group II to 100.0±16.68 units in Group III, 130.7±14.14 units in Group IV and 157.7±7.92 units (Group I). Mean % abnormal sperm morphology was maximum in Group II (36.95±7.87%) followed by Group III (30.66±9.59%), Group IV (11.97±2.74%) and Group I (5.37±1.28%). Statistically, this difference was significant (p<0.001). This study demonstrates different types of abnormal sperm morphology. This study has its own merit that it also depicts the possible improvement after discontinuation of exposure and vitamin C supplementation.
(B)ending the Linearity in the Corporate Front-end of Innovation A Thesis Submitted in Partial Fulfillment of the Requirements for the Degree of Master of Science (M.Sc.) in Management of Technology

The innovation process can be divided into three phases: fuzzy front-end (FFE) or frontend of innovation, new product development (NPD) and commercialization (Koen et al., 2002). During the front-end the product is being defined and the boundaries of the development project are set. Whereas a product innovating company needs to be proficient in all phases of innovation, the front-end has a great importance on the overall innovation performance (Khurana & Rosenthal, 1998). Current models that help to structure this phase follow a linear approach. The author argues that these do not capture real-world practices well and to increase research and development productivity, an alternative solution is needed. Therefore a design science research methodology is applied to design an innovation support framework based on the Cyclic Innovation Model (Berkhout et al., 2006) in this paper. Moreover, a research gap is addressed by combining Technology Readiness Level (TRL) definitions with an innovation model. The operationalized innovation support framework helps practitioners in the activity of maturing an idea to a compelling business proposition. It helps turning implicit decisions about the product concept into explicit choices. Finally, it helps to derive recommendations for complex innovation projects with various product/market combinations.
Clinical signi � cance of D-dimer level in refractory Mycoplasma pneumoniae pneumonia

Xia Huang Children's Hospital of Nanjing Medical University Dan Li Chidren's Hospital of Nanjing Medical University Feng Liu Children's Hospital of Nanjing Medical University Deyu Zhao Children's Hospital of Nanjing Medical University Yifan Zhu Children's Hospital of Nanjing Medical University Heng Tang (  tanham@sina.cn ) Children’s Hospital of Nanjing Medical University https://orcid.org/0000-0003-0095-3816
High-Resolution Images of CO J = 2-1 Emission from the Carbon Star V Cygni

This paper presents observations of the CO J = 2–1 emission from the circumstellar envelope of the mass-losing carbon star V Cyg. The observations were made with the Caltech Millimeter Array. A previously published single-dish map was used to construct short-spacing visibilities not sampled by the interferometer data, thereby recovering missing flux in extended low brightness emission. The images have an angular resolution of ∼1. ″2 with a velocity resolution of 1 MHz (1.3 km s-1). The channel maps are consistent with an expanding envelope that is roughly spherical, but they also show evidence for asymmetric structure, as well as small-scale clumping. We compare these observations, as well as other published spectra, with statistical equilibrium models for CO in a circumstellar envelope. Models that fit the spherically averaged data must invoke a mass-loss rate, Ṁ, that has decreased with time by a factor of ∼2–3 over the past several hundred years. The model kinetic temperature structure in radius, TK(r), decreases as r-0.8 out to r ≈ 6 × 1015 cm and levels off to a constant value at TK = 23 K beyond. The secular change in Ṁ may be related to changes in the stellar luminosity or temperature, as predicted by recent numerical hydrodynamic models for mass loss. The inferred kinetic temperature structure suggests that heating by the photoelectric effect on dust grains is important in the outer envelope.
Replicating Human B Cells Cytosine Deaminase Expression within Pathway Augments Activation-Induced 2 A Cyclooxygenase-2/Prostaglandin E

Within inﬂammatory environments, B cells encountering foreign or self-Ag can develop tertiary lymphoid tissue expressing activation-induced cytosine deaminase (AID). Recently, this DNA-modifying enzyme was detected in nonlymphoid cells within several inﬂamed tissues and strongly implicated in malignant transformation. This study examines whether a cyclooxygenase 2 (COX-2) pathway, often linked to inﬂammation, inﬂuences AID expression in activated B lymphocytes. In this paper, we report that dividing human B cells responding to surrogate C3d-coated Ag, IL-4, and BAFF express AID, as well as COX-2. A progressive increase in AID with each division was paralleled by a division-related increase in a COX-2–linked enzyme, microsomal PGE 2 synthase-1, and the PGE 2 R, EP2. Cells with the greatest expression of AID expressed the highest levels of EP2. Although COX-2 inhibitors diminished both AID expression and IgG class switching, exogenous PGE 2 and butaprost, a selective EP2 agonist, augmented AID mRNA/protein and increased the numbers of IgG + progeny. Despite the latter, the proportion of IgG + cells within viable progeny generally declined with PGE 2 supplementation. This was not due to PGE 2 -promoted differentiation to plasma cells or to greater downstream switching. Rather, because phosphorylated ataxia telangiectasia mutated levels were increased in progeny of PGE 2 -supplemented cultures, it appears more likely that PGE 2 facilitates AID-dependent DNA double-strand breaks that block B cell cycle progression or promote activation-induced cell death, or both. Taken together, the results suggest that a PGE 2 feed-forward mechanism for augmenting COX-2 pathway proteins promotes progressively increased
RRU_A_238746 331..343

Department of Urology, Guy’s and St Thomas’ NHS Foundation Trust, London, UK Abstract: Bladder pain syndrome (BPS) is a chronic condition characterized by pelvic pain or pressure which is perceived to be originating from the bladder, accompanied by one or more urinary symptoms, including frequency, urgency and nocturia. The precise etiology of BPS is not fully understood. Chronic bacterial infection, defective glycosaminoglycan (GAG) layer of the bladder urothelium, inappropriate activation of mast cells in the suburothelial layer of the bladder, autoimmune-mediated mechanisms and autonomic nervous system dysfunction have all been implicated. Treatments targeted at each of these mechanisms have been developed with mixed outcomes. High-quality research into the treatment options is lacking and it is difficult to draw definite conclusions. The treatment approach is multimodal and should be patient specific, targeting the symptoms which they find most bothersome. Conservative treatment, including patient education, behavioural modification, dietary advice, stress relief and physical therapy is an essential initial management strategy for all patients. If no response is observed, oral treatments such as amitriptyline are likely to offer the greatest response. Cystoscopy is essential to phenotype patients, and Hunner lesion directed therapy with fulguration or resection can be performed at the same time. Intravesical instillation of DMSO or lidocaine, detrusor injections of botulinum toxin A and neuromodulation can be used if initial management fails to improve symptoms. Oral cyclosporin can be trialled in those experienced with its use; however, it is associated with significant adverse events and requires intense monitoring. Lastly, radical surgery should be reserved for those with severe, unremitting BPS, in which quality of life is severely affected and not improved by previously mentioned interventions. Future work investigating exact aetiological factors will help target the development of efficacious treatment options, and several promising oral and intravesical treatments are emerging.
Noise robustness of the incompatibility of quantum measurements

The existence of incompatible measurements is a fundamental phenomenon having no explanation in classical physics. Intuitively, one considers given measurements to be incompatible within a framework of a physical theory, if their simultaneous implementation on a single physical device is prohibited by the theory itself. In the mathematical language of quantum theory, measurements are described by POVMs (positive operator valued measures), and given POVMs are by definition incompatible if they cannot be obtained via coarse-graining from a single common POVM; this notion generalizes noncommutativity of projective measurements. In quantum theory, incompatibility can be regarded as a resource necessary for manifesting phenomena such as Clauser-Horne-Shimony-Holt (CHSH) Bell inequality violations or Einstein-Podolsky-Rosen (EPR) steering which do not have classical explanation. We define operational ways of quantifying this resource via the amount of added classical noise needed to render the measurements compatible, i.e., useless as a resource. In analogy to entanglement measures, we generalize this idea by introducing the concept of incompatibility measure, which is monotone in local operations. In this paper, we restrict our consideration to binary measurements, which are already sufficient to explicitly demonstrate nontrivial features of the theory. In particular, we construct a family of incompatibility monotones operationally quantifying violations of certain scaled versions of the CHSH Bell inequality, prove that they can be computed via a semidefinite program, and show how the noise-based quantities arise as special cases. We also determine maximal violations of the new inequalities, demonstrating how Tsirelson's bound appears as a special case. The resource aspect is further motivated by simple quantum protocols where our incompatibility monotones appear as relevant figures of merit.
Combination Therapy with Pema�brate (K-877) and Pitavastatin Improves Vascular Endothelial Dysfunction in Dahl/Salt-sensitive Rats Fed a High-salt and High-fat Diet

Background: Statins suppress the progression of atherosclerosis by reducing low-density lipoprotein (LDL) cholesterol levels. Pema�brate (K-877), a novel selective peroxisome proliferator-activated receptor α modulator, is expected to reduce residual risk factors including high triglycerides (TGs) and low high-density lipoprotein (HDL) cholesterol during statin treatment. However, it is not known if statin therapy with add-on pema�brate improves the progression of atherosclerosis. The aim of this study was to assess the effect of combination therapy with pitavastatin and pema�brate on lipid pro�les and endothelial dysfunction in hypertension and insulin resistance model rats. Methods: Seven-week-old male Dahl salt-sensitive (DS) rats were divided into the following �ve treatment groups (normal diet (ND) plus vehicle, high-salt and high-fat diet (HD) plus vehicle, HD plus pitavastatin (0.3 mg/kg/day), HD plus pema�brate (K-877) (0.5 mg/kg/day), and HD plus combination of pitavastatin and pema�brate) and treated for 12 weeks. At 19 weeks, endothelium-dependent relaxation of the thoracic aorta in response to acetylcholine was evaluated. Results: After feeding for 12 weeks, systolic blood pressure and plasma levels of total cholesterol were signi�cantly higher in the HD-vehicle group compared with the ND-vehicle group. Combination therapy with pitavastatin and pema�brate signi�cantly reduced systolic blood pressure, TG levels, including total, chylomicron (CM), very LDL (VLDL), HDL-TG, and cholesterol levels, including total, CM, VLDL, and LDL-cholesterol, compared with vehicle treatment. Acetylcholine caused concentration-dependent relaxation of thoracic aorta rings that were pre-contracted with phenylephrine in all rats. Relaxation rates in the HD-vehicle group were signi�cantly lower compared with the ND-vehicle group. Relaxation rates in the HD-combination of pitavastatin and pema�brate group signi�cantly increased compared with the HD-vehicle group, although neither medication alone ameliorated relaxation rates signi�cantly. Western blotting experiments showed increased phosphorylated endothelial nitric oxide synthase protein expression in aortas from rats in the HD-pemabrate group and the HD-combination group compared with the HD-vehicle group. However, the expression levels did not respond signi�cantly to pitavastatin alone. Conclusions: Combination therapy with pitavastatin and pema�brate improved lipid pro�les and endothelial dysfunction in hypertension and insulin resistance model rats. Pema�brate as an add-on strategy to statins may be useful for preventing atherosclerosis progression.
EFFECTS OF ELEVATED ATMOSPHERIC CO2 ON WATER CHEMISTRY AND MOSQUITO (DIPTERA: CULICIDAE) GROWTH UNDER COMPETITIVE CONDITIONS IN CONTAINER HABITATS

A BSTRACT We investigated the direct and indirect effects of elevated atmospheric CO 2 on freshwater container habitats and their larval mosquito occupants. We predicted that a doubling of atmospheric CO 2 would (1) alter the chemical properties of water in this system, (2) slow deg- radation of leaf litter, and (3) decrease larval growth of Aedes albopictus (Skuse) mosquitoes raised on that litter under competitive conditions. Effects of elevated CO 2 on water quality parameters were not detected, but the presence of leaf litter signiﬁcantly reduced pH and dissolved oxygen relative to water-ﬁlled containers without litter. Degradation rates of oak leaf litter from plants grown under elevated CO 2 atmospheres did not differ from breakdown rates of litter from ambient CO 2 conditions. Litter from plants grown in an elevated CO 2 at- mospheres did not inﬂuence mosquito population growth, but mosquito production decreased signiﬁcantly with increasing larval density. Differences among mosquito density treatments inﬂuenced survivorship most strongly among male Ae. albopictus and time to emergence most strongly among females, suggesting fundamental sex-determined differences in re- sponse to competition. Results of this and other studies indicate that direct and indirect effects of doubled atmospheric CO 2 are minimal in artiﬁcial containers with freshwater.
A Multiple Cohort Study of the Gender Gradient of Life Satisfaction during Adolescence: Longitudinal Evidence from Great Britain*

This study is unique in exploiting 12 youth cohorts (aged 11 – 15) from the British Household Panel Survey (BHPS) and the UK Household Longitudinal Study (UKHLS) spanning 1996 – 2017 to investigate the gender gradient of adolescent life satisfaction. We ﬁ nd robust evidence of a cross-cohort gender gap particularly at the extremes of the adolescent life satisfaction distribution. Male adolescents are signi ﬁ cantly more likely to report complete life satisfaction (by around 6% – 14%) and females to report dissatisfaction (by around 3% – 7%) indicating a higher female depression propensity. An intra-household gender gap is found for female adolescents raised with opposite sex siblings. Previous period life satisfaction is the strongest determinant of prospective higher self-reported male satisfaction levels.
Investigating the Effect of Transformational Leadership In Mutual Fund Accounting and Administration

Mutual fund accounting firms are experiencing rapid change through the deployment of increased automation and artificial intelligence. Such an environment is an ideal playground for transformational leaders. This study investigated how the transformational leadership of midlevel managers influenced subordinates at a Mutual Fund Accounting and Administration division. The Leadership Practices Inventory was used to investigate how five components of transformational leadership were related to subordinates’ job satisfaction, organizational commitment, and productivity. A partial least squares path modeling analysis was conducted. The results suggest that enabling others to act is significantly associated with subordinates’ job satisfaction. Inspiring a shared vision is significantly associated with subordinates’ organizational commitment. And modeling the way and inspiring a shared vision are associated with subordinates’ productivity. This research provides empirical evidence to support the continued use of the Leadership Practices Inventory in future academic research and in transformational leadership training programs for practitioners.
Analyzing Factors that Influence Public Sector Procurement Reverse Auction System: A Review

– This study was performed to review the conceptualization and relationships among user behaviour, system quality and intention to use eBidding, an eGovernment auction system with user satisfaction as the moderator. From the theoretical framework, user behaviour and system quality factors have significant relationships with the adoption of information system (IS). Empirical evidence also shows that satisfaction has a significant moderating effect on the relationship between system quality factors with the adoption of IS. Given the significant impact of behavioural factors of officials in eBidding adoption and role satisfaction on the intention and use of eGovernment system, system managers could introduce key changes in the workplace to increase satisfaction to address the problems of low eBidding adoption among users. Copyright © 2014 Penerbit Akademia Baru - All rights reserved.
Classical capacity of the noisy bosonic channel and the bosonic minimum output entropy conjecture

We consider a line with noise in the simplest case. Loss does not add noise. Amplification via phase insensitive amplifiers do add noise. A lower bound of this capacity is the quantum analog to the Shannon capacity of a linear channel with additive white Gaussian noise, namely the difference of the Von Neumann entropy of the signal plus noise at the output of the line and the entropy of the noise alone. We show that this expression is indeed the capacity for the case of an amplifier with infinitesimal gain $G = 1+\epsilon$, and for a cascade of an amplifier with arbitrary gain and a large loss, such that the overall gain of the cascade is infinitesimal.
Influenza A Virus-Induced B Signaling on the k Essential Impact of NF-Stephan

Systemic infections of humans and birds with highly pathogenic avian inﬂuenza A viruses of the H5N1 subtype are characterized by inner bleedings and a massive overproduction of cytokines known as cytokine storm. Growing evidence supports the role of endothelial cells in these processes. The aim of this study was to elucidate determinants of this strong response in endothelial cells with a focus on the transcription factor NF- (cid:1) B. This factor is known as a major regulator of inﬂammatory response; however, its role in inﬂuenza virus replication and virus-induced immune responses is controversially discussed. By global mRNA proﬁling of infected cells in the presence or absence of a dominant negative mutant of I (cid:1) B kinase 2 that speciﬁcally blocks the pathway, we could show that almost all H5N1 virus-induced genes depend on functional NF- (cid:1) B signaling. In particular, activation of NF- (cid:1) B is a bottleneck for the expression of IFN- (cid:2) and thus inﬂuences the expression of IFN-dependent genes indirectly in the primary innate immune response against H5N1 inﬂuenza virus. Control experiments with a low pathogenic inﬂuenza strain revealed a much weaker and less NF- (cid:1) B-dependent host cell response. The Journal of Immunology, 2009, 183: 5180–5189. Ascertainment of Regulatory Relationships Inferred from Expression) de- scribed by Haverty et al. (37). Brieﬂy, microarray data and promoter se-quence data derived from the TRANSFAC database 7.0 are conﬂated. The promoter regions of the group of unregulated genes are compared with the promoters of regulated genes to compute the relative overabundance of cis -elements in the group of regulated genes. Thereby transcription factor binding sites are detected which potentially contribute to the regulation of a given group of genes according to their signiﬁcance of overrepresentation.