Miracle-dz/UniFAR-FTUs huggingface dataset:
Evaluation of Stent Angioplasty in the Treatment of Arteriosclerotic Lesions of the Common Femoral Artery

In many vascular segments, endovascular therapy is the treatment of choice for arteriosclerotic lesions. For the treatment of common femoral artery (CFA) lesions, surgical reconstruction is still considered the gold standard. The purpose of this study is to evaluate the safety and efficacy of stent angioplasty for the treatment of common femoral artery (CFA) lesions in a real-world population during a two-year follow up. This retrospective, single-center study includes 250 patients requiring treatment with stent angioplasty of CFA lesions. The primary end point was the target lesion revascularization (TLR) rate. Secondary end points were the overall procedural complication rate, the rate of ipsilateral CFA punctures during follow-up, changes in the Rutherford–Becker class (RBC) and ankle–brachial index (ABI), primary patency rates, amputation rate, time to and the type of TLR. A total of 236 interventions (94.4%) were successfully defined as a residual stenosis < 30%. Periinterventionally, there were 23 complications (9.1%), 3 of which had to be treated surgically. Median follow up was 21 months (average 19.2 ± 7.8). In total, 41 patients (16.4%) needed a TLR. The primary patency rate was 90.8%, 81.2% and 72% at 6, 12 and 24 months, respectively. ABI and RBC were significantly better at all time points compared to baseline. During follow up, seven amputations (three minor and four major) had to be performed. More than half of the patients (56.0%) were punctured at the stented CFA during the follow up. Multivariate logistic regression analysis showed continued nicotine use and coronary heart disease as predictors for TLR. Stent angioplasty for the treatment of CFA lesions is safe and effective. Further studies are needed to compare this endovascular option with surgical therapy.
Stability Criteria for Time-Delay Systems From an Insightful Perspective on the Characteristic Equation

This article provides a delay-dependent and a necessary and sufficient delay-independent stability criterion for linear autonomous continuous-time systems with a discrete delay. We take a simple perspective on the two-variable formulation of the characteristic equation, which leads to the following advantageous but not widespread delay-independent criterion: The sum of the coefficient matrix of the delay-free term and the elementwise unitarily rotated matrix of the delay term must remain Hurwitz for all rotation angles. A graphical test for the latter is shown to require no more than three lines of code. Concerning delay-independent stability, our main contribution is to extend this sufficient criterion to a necessary and sufficient one. Concerning delay-dependent stability, the focus is on the critical delay that bounds the initial delay interval of stability. We formulate a constrained minimization problem that gives the exact value of this critical delay. The taken perspective is especially insightful in terms of how the coefficient matrices may look like, and, for scalar systems, the delay-dependent stability chart becomes obvious at a first glance. The presented criteria are complementary to the well-known frequency-sweeping test, which results from another of three possible perspectives on the two-variable criterion. Besides of a unified treatment of these different perspectives, the article also discusses corollaries of the one taken, which include Mori’s famous criterion.
Perfil da Cultura de Segurança do Paciente em um Hospital Público

Objetivo: Avaliar o perfil da cultura de segurança do paciente de um hospital público de Salvador-Bahia na visão de enfermeiras líderes. Metodologia: Estudo exploratório descritivo, transversal do tipo survey interseccional de abordagem quantitativa. Utilizou-se o questionário “Pesquisa sobre Segurança do Paciente em Hospitais” da Agency for Healthcare Research and Quality.Resultados: 80,9% são coordenadoras de enfermagem. A dimensão de área forte foi “Expectativas e ações do supervisor/chefia para promoção da segurança do paciente” apresentando 80,9% de respostas positivas. As dimensões de áreas com potencial para a melhoria da segurança foram “Apoio da gestão hospitalar para a segurança do paciente”, “Trabalho em equipe na unidade” e “Aprendizado organizacional/melhoria contínua”. As demais dimensões foram consideradas de áreas frágeis (66%). 34% das enfermeiras líderes não realizaram nenhuma notificação de evento adverso, no período de 12 meses. 59% das participantes avaliaram a segurança do paciente como regular. Discussão: Os resultados não devem ser interpretados isoladamente, requerem visão de conjunto com outras características do hospital e o contexto sócio, político e econômico do país. Conclusão: O perfil da cultura de segurança foi classificado como frágil, no entanto, a cultura de segurança do paciente está sendo construída de maneira efetiva na instituição.
Does personality predict a likelihood display of organisational citizenship behaviours among university students? Empirical evidence from Ghana

Organisational citizenship behaviour (OCB) has received extensive research attention among the employed populations. But is it possible that people who are yet to be employed can display intentional OCB? Numerous studies have linked OCB to many factors including personality. We, therefore, set out to examine the association between personality traits on the likelihood of engaging in citizenship behaviours among undergraduate students. Using a cross-sectional survey design, data was gathered from 1009 students comprising 537 males and 472 females, with a mean age of 23 (SD=2.98 years) from the University of Ghana through purposive sampling. A questionnaire consisting of validated scales such as the 50-item International Personality Item Pool (IPIP) and the OCB Checklist (OCB-C) were employed to measure the ‘Big Five’ personality traits and the likelihood of OCB respectively. Hierarchical multiple regression analysis revealed that sex and age were related to the likelihood of OCB such that male and older students were more willing to engage in OCB. Among the personality traits, agreeableness, conscientiousness, emotional stability and intellect had significant relationships with the likelihood of OCB. This study shows that both demographic and personal characteristics such as personality traits are associated with students’ likelihood of engaging in OCB.
Thermal Conductivity and Rheological Studies for Graphene-Al2O3 / Ethylene Glycol-Water Hybrid Nanofluid at Low Temperatures

In this study, the effect of nanoparticle concentration and temperature on the thermophysical properties of graphene-Al2O3/ethylene glycol-water hybrid nanofluid at low temperatures was experimentally investigated. The nanoparticles were characterized by XRD, SEM, TEM and BET methods. The dynamic viscosity and thermal conductivity of the hybrid nanofluids were experimentally determined at different volume concentrations of nanoparticles (0.05%, 0.1%, 0.5%, 1%, 1.5%, 2%, and 2.5%) and at temperatures ranging from 263 to 303 K. The experimental results showed that the incorporation of nanoparticles into the base fluid significantly increased the viscosity. The hybrid nanofluid with solid volume fractions less than 0.5% exhibited Newtonian behavior, while those with higher solid volume fractions (0.5% - 2.5%) exhibited shear-thinning non-Newtonian behavior and followed the power law model. The hybrid nanofluids showed surprising behavior at sub-zero temperatures and low concentration, which can be attributed to oleic acid and graphene nanoplatelets. The thermal conductivity of the hybrid nanofluids increased with increasing temperature and volumetric concentration of the nanoparticles. The ratios of thermal conductivity were increased by about 44.02% and 4.07% at 303 K and 263 K, respectively, with a solid concentration of 2.5 vol%. Based on the experimental results, a reliable correlation was presented to evaluate the thermal conductivity of graphene-Al2O3/ethylene glycol-water hybrid nanofluid at different temperatures and nanoparticle concentrations.
Should We Insure Workers or Jobs During Recessions?

What is the most efficient way to respond to recessions in the labor market? To this question, policymakers on the two sides of the pond gave diametrically opposed answers during the COVID-19 crisis. In the United States, the focus was on insuring workers by increasing the generosity of unemployment insurance. In Europe, instead, policies were concentrated on saving jobs, with the expansion of short-time work programs to subsidize labor hoarding. Who got it right? In this article, we show that far from being substitutes, unemployment insurance and short-time work exhibit strong complementarities. They provide insurance to different types of workers and against different types of shocks. Short-time work can be effective at reducing socially costly layoffs against large temporary shocks, but it is less effective against more persistent shocks that require reallocation across firms and sectors. We conclude that short-time work is an important addition to the labor market policy-toolkit during recessions, to be used alongside unemployment insurance.
Impact of Secretion-Active Osteoblast-Specific Factor 2 in Promoting Progression and Metastasis of Head and Neck Cancer

Simple Summary Head and neck cancers (HNC) exhibit poor survival due to metastases. Our study identified osteoblast-specific factor 2 (OSF-2) as overexpressed in primary tumors, lymph node metastases, and the tumor microenvironment. High OSF-2 levels correlate with metastatic disease and reduced survival of HPV-negative HNC patients. OSF-2’s active secretion signal seems to promote metastases by supporting the tumor microenvironment via the ß1 integrin-induced PI3K and Akt/PKB signaling pathway. We suggest OSF-2 as a potential biomarker and drug target to control (HPV-negative) HNC metastasis and disease management. Abstract Treatment success of head and neck cancer (HNC) is still hampered by tumor relapse due to metastases. Our study aimed to identify biomarkers by exploiting transcriptomics profiles of patient-matched metastases, primary tumors, and normal tissue mucosa as well as the TCGA HNC cohort data sets. Analyses identified osteoblast-specific factor 2 (OSF-2) as significantly overexpressed in lymph node metastases and primary tumors compared to normal tissue. High OSF-2 levels correlate with metastatic disease and reduced overall survival of predominantly HPV-negative HNC patients. No significant correlation was observed with tumor localization or therapy response. These findings were supported by the fact that OSF-2 expression was not elevated in cisplatin-resistant HNC cell lines. OSF-2 was strongly expressed in tumor-associated fibroblasts, suggesting a tumor microenvironment-promoting function. Molecular cloning and expression studies of OSF-2 variants from patients identified an evolutionary conserved bona fide protein secretion signal (1MIPFLPMFSLLLLLIVNPINA21). OSF-2 enhanced cell migration and cellular survival under stress conditions, which could be mimicked by the extracellular administration of recombinant protein. Here, OSF-2 executes its functions via ß1 integrin, resulting in the phosphorylation of PI3K and activation of the Akt/PKB signaling pathway. Collectively, we suggest OSF-2 as a potential prognostic biomarker and drug target, promoting metastases by supporting the tumor microenvironment and lymph node metastases survival rather than by enhancing primary tumor proliferation or therapy resistance.
Motivations and barriers for clinical mental health help-seeking in Bangladeshi university students: a cross-sectional study

Abstract Background University and college students are vulnerable to developing depressive symptoms. People in low-income countries are disproportionately impacted by mental health problems, yet few studies examine routes to accessing clinical services. Examining motivation and barriers toward seeking clinical mental health services in university students in Bangladesh is important. Method Using a cross-sectional survey (n = 350), we assess the relationship between the constructs of autonomy, relatedness, and competency toward using clinical mental health practices (i.e. using professional resources, taking medication) with (1) positive views, (2) perceived need, and (3) use of clinical mental health services among Bangladeshi university students. Results Results showed that the perceived need for mental health support was the predictor of the largest magnitude (aOR = 4.99, p = 0.005) for using clinical services. Having a positive view of clinical services was predictive of clinical service use (aOR = 2.87, p = 0.033); however, that association became insignificant (p = 0.054) when adjusting for the perceived need for mental health care. Of the SDT constructs, social influences were predictive of perceiving a need for mental health support, and mental health knowledge was predictive (aOR = 1.10, p = 0.001) of having a positive view of clinical mental health care. Conclusion Our findings show that knowledge of mental health is associated with positive views of mental health services, and that higher levels of stress and the presence of people with mental health problems are associated with the perception of a need for mental health care, which is ultimately responsible for using the services.
A Sensitive LC-MS/MS Method for the Simultaneous Determination of Two Thia-Analogous Indirubin N-Glycosides and Indirubin-3′-Monoxime in Plasma and Cell Culture Medium

Indirubin was identified as an active component of Danggui Longhui Wan, an herbal mixture used in traditional Chinese medicine, and showed anticancer activity in clinical trials in patients with chronic leukemia. Investigations on the mechanisms of antitumor action of indirubins have mainly focused on the indirubin derivative indirubin-3′-monoxime (I3M). Meanwhile, antiproliferative and cytotoxic properties on cancer cells have also been demonstrated for several synthetic indirubin N-glycosides. In the present study, we demonstrate cytotoxic activity of the thia-analogous indirubin N-glycosides KD87 (3-[3′-oxo-benzo[b]thiophen-2′-(Z)-ylidene]-1-(β-d-glucopyranosyl)-oxindole) and KD85 (3-[3′-oxo-benzo[b]thiophen-2′-(Z)-ylidene]-1-(β-d-mannopyranosyl)-oxindole) against melanoma and squamous cell carcinoma cells as well as lung cancer and glioblastoma cells. The advanced state of preclinical studies on the effects of indirubins conducted to date underscores the need for pharmacokinetic data from cellular, animal, and human studies for which reliable quantification is required. Therefore, a sensitive liquid chromatography-tandem mass spectrometric (LC-MS/MS) method was developed and validated for the simultaneous measurement of KD87, KD85, and I3M in plasma and cell culture medium. Experimental conditions for sample preparation were optimized for human plasma protein precipitation and liquid-liquid extraction from plasma and cell culture medium. The methods were successfully validated in accordance with the U.S. Food and Drug Administration Bioanalytical Method Validation and evaluated for selectivity, sensitivity, matrix effect, recovery, carryover, calibration curve linearity, accuracy, precision, and stability. The applicability of the methods was demonstrated by the determination of KD87 in mouse plasma after prior intraperitoneal administration to mice.
Effects of Short Video Addiction on the Motivation and Well-Being of Chinese Vocational College Students

While media use can be beneficial in some ways, excessive use of media has led to growing concerns about its potential negative consequences. With the popularity of Chinese video applications (apps) such as DouYin, TikTok, Kwai, and other short video apps sweeping through schools around the world. Due to the diversity and immersion principle of short videos, their popularity continues to grow, and the phenomenon of students being addicted to short videos also brings many hidden dangers to the learning effect. Among other things, the problem of excessive use of the Internet among Chinese youth has led the government to propose a series of control policies to strengthen the monitoring of harmful habits of youth in the use of online applications. In addition, the problem of youth addiction to short videos has become a major concern for education experts and the general public, thus demonstrating that short video addiction is indeed an ongoing research issue. Therefore, this study aimed to understand the causes of short-form video addiction and its impact on the psychology of learning, and to investigate the relationship between short-form video flow experience, short-form video addiction, intrinsic and extrinsic learning motivation, and learning well-being from the perspectives of flow experience theory and micro ecological systems. The questionnaire was sent via instant messaging software such as QQ and WeChat, and university students from vocational colleges in China were invited to complete the questionnaire. A total of 517 valid data were collected, including 222 (42.9%) were male students and 295 (57.1%) were female students. The collected questionnaires were analyzed for reliability and validity after removing incomplete data, followed by structural equation modeling for model verification. The findings showed that: (1) short video flow experience had a positive effect on short video addiction; (2) short video addiction had a negative effect on intrinsic and extrinsic learning motivation; (3) intrinsic and extrinsic learning motivation had a positive effect on learning well-being; (4) short video flow experience had an indirect negative effect on intrinsic and extrinsic learning motivation; (5) short video flow and short video addiction had indirect negative effects on learning well-being. According to the results, it is clear that addiction to short videos has a negative impact on learners' learning motivation and positive psychology of learning, so parents and teachers should effectively guide students to use short video apps in a self-controlled way.
PRE-SERVICE SCIENCE AND COMPUTER TEACHERS’ VIEWS ON TEACHING PRACTICE COURSES

The Teaching Practice course taught in Education Faculties gives pre-service teachers real experience before starting the profession. This study aims to examine the teaching practice courses in the undergraduate programs of education faculties by the views of pre-service science and computer teachers. 50 4th grade students, 25 from the science education department and 25 from the computer and instructional technology education department, participated in the study. Within the scope of the study, the data were collected through online interviews of approximately 30 minutes with the participants, and content analysis was made. According to the findings, pre-service teachers believe that teaching practice courses are insufficient to ensure active participation in lessons in terms of learning gains and content and that they lack a flexible structure that allows them to participate in classes at various grade levels. They also stated that the teaching practice course includes result-oriented measurement and evaluation activities. However, they underlined that the semesters and credits allocated to undergraduate teaching practice courses are insufficient. Furthermore, throughout the process, pre-service teachers reported some communication and coordination issues in the teaching practice course. They suggested that every university with an education faculty should open practice schools that include all levels of compulsory education to overcome the challenges encountered during the process. Keywords: computer teaching, pre-service teachers, science teaching, teaching practice course
The Push and Pull of Cybersecurity Adoption: A Positional Paper

: The intensity and frequency of cyber breaches has brought cybersecurity into the spotlight. This has led to cybersecurity becoming a major concern and stream of research for practitioners and researchers alike. However, despite the negative effects associated with cyber breaches, there remains a limited understanding surrounding the adoption of cybersecurity measures. Specifically, to date, how the interaction of external and internal forces affect cybersecurity adoption remains unclear. We provide an overview of the reasons for a passive posture against cybersecurity, as well as the internal and external forces that push for cybersecurity adoption. We examine the tension of the push and pull of internal and external forces, identify a gap, and propose future research directions.
Effect of Pupal Cold Storage on Reproductive Performance of Microplitis manilae (Hymenoptera: Braconidae), a Larval Parasitoid of Spodoptera frugiperda (Lepidoptera: Noctuidae)

Simple Summary Parasitoids are one of the most important biological control agents, and there are increasing requirements for long-term breeding. It is critical to figure out the parasitoid biological properties and disclose the effects of cold storage on them to extend their longevity. In this study, we investigated the field parasitism rate and clarified the biological parameters of Microplitis manilae, a dominant larval parasitoid of Spodoptera frugiperda. Further analysis revealed that the pupal cold storage, including different storage temperatures, storage period and storage time, significantly affected the emergence rate, parasitism rate and longevity of wasp adults, and the optimal storage condition was middle-aged pupae stored at 10 °C for 5–10 d. These results provide a novel insight into the mass-rearing of M. manilae and contribute to the biological control using M. manilae against S. frugiperda. Abstract As a major invasive pest in China, Spodoptera frugiperda (Smith) (Lepidoptera: Noctuidae) has caused great damage to crops. Hymenopteran parasitoids, especially the braconid wasps, play crucial roles in depressing pest populations. However, there was little information about the ideal storage of parasitoids to achieve their mass-rearing. Here, we identified a dominant parasitoid of S. frugiperda, Microplitis manilae (Ashmead) (Hymenoptera: Braconidae), in the Hainan province of China with a field parasitism rate of 5.66–19.10%. The investigation of biological parameters revealed that the parasitism rate of M. manilae significantly decreased with an increase in both wasp adult longevity and host age, and the wasp of 1–3 d post eclosion performed best on the first instar of host larvae, showing the highest parasitism rate. We also discovered that the decreased temperature from 30 to 20 °C greatly extended the longevity of wasp adults, and a similar result was observed after feeding on 10% sucrose water compared with sterile water. Then, the effects of different pupal cold storage temperatures (4 and 10 °C), storage period (prepupa, middle-aged pupa, late-aged pupa) and storage time (5, 10 or 20 d) on the emergence rate, parasitism rate, female proportion and longevity of M. manilae were investigated. The results demonstrated that the middle-aged wasp pupae stored at 10 °C for 5–10 d possessed a stronger parasitic ability and longer longevity. These findings may promote the flexibility and efficacy of large-scale production of M. manilae, thus contributing to its biological field control against S. frugiperda.
Object mass nouns and subkind countability

We argue for a novel cross-linguistic definition of object mass nouns—e.g. furniture, equipment—that accommodates the novel observation that some can combine with numericals to count subkinds. We present novel data from Hungarian, where certain object mass nouns can combine directly with numericals to count subkinds but not objects—e.g. három sportruházat (`three sportswear’) can refer to three kinds of sportswear but not three pieces of sportswear. This is unexpected, given that the inability to count subkinds is a property of object mass nouns in English (Cowper & Hall 2012, Rothstein 2017, Grimm & Levin 2017, Sutton & Filip 2018). This requires a novel definition of object mass nouns, which has implications for how they are identified across languages.