Miracle-dz/UniFAR-FTUs huggingface dataset:
Current and future trends in periodontal tissue engineering and bone regeneration

Periodontal tissue engineering involves a multi-disciplinary approach towards the regeneration of periodontal ligament, cementum and alveolar bone surrounding teeth, whereas bone regeneration specifically applies to ridge reconstruction in preparation for future implant placement, sinus floor augmentation and regeneration of peri-implant osseous defects. Successful periodontal regeneration is based on verifiable cementogenesis on the root surface, oblique insertion of periodontal ligament fibers and formation of new and vital supporting bone. Ultimately, regenerated periodontal and peri-implant support must be able to interface with surrounding host tissues in an integrated manner, withstand biomechanical forces resulting from mastication, and restore normal function and structure. Current regenerative approaches utilized in everyday clinical practice are mainly guided tissue/bone regeneration-based. Although these approaches have shown positive outcomes for small and medium-sized defects, predictability of clinical outcomes is heavily dependent on the defect morphology and clinical case selection. In many cases, it is still challenging to achieve predictable regenerative outcomes utilizing current approaches. Periodontal tissue engineering and bone regeneration (PTEBR) aims to improve the state of patient care by promoting reconstitution of damaged and lost tissues through the use of growth factors and signaling molecules, scaffolds, cells and gene therapy. The present narrative review discusses key advancements in PTEBR including current and future trends in preclinical and clinical research, as well as the potential for clinical translatability.
Emotional Intelligence, Job Satisfaction and Organisational Performance in the Malaysian Public Administration

In the public sector, organisational performance is key to delivering quality services to its stakeholders. Nevertheless, the public service in Malaysia is seen to be less competitive as it only ranks 24th in the World Competitiveness Report in 2017, has worsened from its 12th position in 2014. This study aims to examine the link between emotional intelligence, job satisfaction and organisational performance in the public administration using survey data obtained from 365 administrative and diplomatic officers. The Partial Least Square method is employed to study the link. The findings indicate that emotional intelligence has a positive direct effect on job satisfaction, and similarly, job satisfaction has a positive direct effect on organisational performance. Nevertheless, contrary to the claims of scholars, the study finds no evidence of any significant relationship on the indirect effect of emotional intelligence on organisational performance through the mediating effect of job satisfaction. This further intensifies the need to ensure the job satisfaction of the administrative and diplomatic officers of the public sector is given due attention to move organisational performance forward.
Effect of Listening to Holy Qur'an during labor on its Progress, Maternal and Neonatal outcome

Background: labor pain one of the most intense forms of pain that can be experienced, leads to fear and anxiety can produce muscle tension, with possibly prolong the first and second stage of labor, to avoid pharmacological or invasive methods of pain relief in labor and implement listening to Holy Qur'an during labor. The aim of this study is to evaluate effect of listening of holy Qur'an during labor on maternal and neonatal outcome. Subjects and methods: Design: This quasi-experimental study was conducted in maternity Unit in El-Nabawy El Mohandes Hospital, Fayoum governorate and in Al-Galaa hospital, Cairo governorate; on 100 full term parturient Muslim women were classified into two groups, intervention (n.50) and control (n.50). The intervention group was listened to Quran recitation by a CD-player through an occlusive headphone. Sociodemographic and obstetric data ,Labor progress and outcome assessment, Visual analog pain severity scale, visual analog scale for anxiety, The Pain Coping Scale were used as research tools. Results: study illustrated that the mean duration of first stage of labor ,mean score of anxiety was significantly lower, Meanwhile mean pain coping score, spontaneous vaginal delivery were significantly higher in Quran group. Conclusion: Listening to Quran during labor, appears to be an effective in reducing anxiety, magnify ability to cope pain, leading to spontaneous vaginal delivery. Recommendations: Quran can enrich the non-pharmacological pain management in labor.
Effect of Educational Program About Self-care Practices on Preventing Occurrence of Vaginal Infection Among Gestational Diabetic Women

Background: gestational diabetes women are reported to be high risk for infections of the genital tract. Controlling vaginal infections rested on the nurse through educating women self-care practices. Aim: Assess effect of educational program about self-care practices on prevention occurrence of vaginal infection among gestational diabetic women. Methods: Quasi experimental research design was used in this study. It was conducted at antenatal outpatient clinic of South Valley University’s Hospital. Sample included 60 pregnant women with diabetes mellitus. Structured interview questionnaire was used and involved three parts. An educational program about care of genital system was carried out on pregnant women with gestational diabetes. Results: There is statistical significant difference between control and study groups regarding total self-care practices and occurrence of genital infection P- values are 0.001. Conclusion: There was a vital role to the educational program about self-care practices on preventing occurrence of vaginal infection among pregnant women. Recommendations: Planning and implementing educational program as a routine hospital care with providing a brochure about genital hygienic practices to reduce rate of vaginal infection among gestational diabetes women.
Profitability Variables and Bank Size Effects on Corporate Zakat: Evidence from Indonesian Islamic Banks

Islamic banks carry out their operational activities based on Islamic principles. Thus, they are not only required to pay taxes but also zakat of 2.5 percent with several conditions. Theoretically, zakat has an impact on Islamic banks larger expenditures compared to conventional banks which are not obliged to. This research examines and analyzes the extent to which profitability variables which are ROA, ROE, and BOPO, and bank size which is represented by total assets, can affect corporate zakat expenditure by Islamic Commercial Banks (BUS) in Indonesia. To do so, the Panel Vector Error Correction Model (PVECM) is used to analyze the subject matters which the period covers from 2012 to 2017. This work finds that in the short-run, all the independent variables were insignificant. However, in the long-run only ROE and BOPO which were significant. The results of the Impulse Response Function (IRF) analysis showed that the dependent variable responds to the shock of its independent variables with fluctuating and even negative trend. In addition, the results of Variance Decomposition (VDC) analysis showed that the contribution of profitability variables and bank size tended to decrease toward the formation of corporate zakat expenditure by BUS until the end of the research period. Keywords: Corporate Zakat Expenditure, Islamic Banks, Profitability, Bank Size, PVECM
Disparities in particulate matter (PM10) origins and oxidative potential at a city scale (Grenoble, France) – Part 1: Source apportionment at three neighbouring sites

Abstract. A fine-scale source apportionment of PM10 was conducted in three different urban sites (background, hyper-center, and peri-urban) within 15 km of the city in Grenoble, France using Positive Matrix Factorization (PMF 5.0) on measured chemical species from collected filters (24 h) from February 2017 to March 2018. To improve the PMF solution, several new organic tracers (3-MBTCA, pinic acid, phthalic acid, MSA, and cellulose) were additionally used in order to identify sources that are commonly unresolved by classic PMF methodologies. An 11-factor solution was obtained in all sites, including commonly identified sources from primary traffic (13 %), nitrate-rich (17 %), sulfate-rich (17 %), industrial (1 %), biomass burning (22 %), aged sea salt (4 %), sea/road salt (3 %), and mineral dust (7 %), and the newly found sources from primary biogenic (4 %), secondary biogenic oxidation (10 %), and MSA-rich (3 %). Generally, the chemical species exhibiting similar temporal trends and strong correlations showed uniformly distributed emission sources in the Grenoble basin. The improved PMF model was able to obtain and differentiate chemical profiles of specific sources even at high proximity of receptor locations, confirming its applicability in a fine-scale resolution. In order to test the similarities between the PMF-resolved sources, the Pearson distance and standardized identity distance (PD-SID) of the factors in each site were compared. The PD-SID metric determined whether a given source is homogeneous (i.e., with similar chemical profiles) or heterogeneous over the three sites, thereby allowing better discrimination of localized characteristics of specific sources. Overall, the addition of the new tracers allowed the identification of substantial sources (especially in the SOA fraction) that would not have been identified or possibly mixed with other factors, resulting in an enhanced resolution and sound source profile of urban air quality at a city scale.
Background Suicide reduction is government strategyinmanycountries. Weneed to quantify the connection betweennon-fatal self-poisoningand eventual suicide. Aims To determinemortality after an episode of self-poisoningand to identify predictors of death by anycause or by suicide

Declaration of interest None. Fundingdetailed in Acknowledgements. Suicide reduction has recently become the aim of governmental strategies in, for example, England (Department of Health, 1993, 2002), the USA (Vastag, 2001), Australasia and Nordic countries (Taylor et al, 1997), and global strategies through a campaign of the World Health Organization (2004). The main suggested targets for intervention have been people with undetected depression and those recently or currently in psychiatric care – usually with ‘severe mental illness’ (as defined in the various policy documents). Less attention has been paid to those who are known to hospital services because of non-fatal self-harm, although recent primary research (Jenkins et al, 2002; Hawton et al, 2003) and systematic review (Owens et al, 2002) have confirmed that their rate of subsequent suicide is far higher than expected. Unfortunately, much research on suicide after non-fatal self-harm is poor, based on small and highly selected samples, weak methods for detecting suicides during follow-up, and flawed analysis (Owens et al, 2002). We therefore set out to determine long-term mortality and cause of death for around 1000 consecutive patients who attended one of the UK’s largest accident and emergency departments because of selfpoisoning during a brief period in the mid-1980s.
Critical Thinking Attitude and Some Other Variables in Predicting Students’ Democratic Attitudes

This research was conducted to determine the effects of the attitudes towards critical thinking, gender, socioeconomic factors (education level of parents, income level, place of residence) as well as academic success, reading and television viewing habits in predicting the democratic attitudes of the fourth grade students. The research was carried out with the participation of 1066 students studying in the 4th grades of primary schools in the central districts of Diyarbakır in the 2017-2018 academic year. The study is descriptive and has a relational screening model. The "Democratic Attitude Scale" (DAS) developed by Erbil and Kocabaş (2017) was employed to determine the students' democratic attitudes and the "Critical Thinking Attitude Scale" (CTAS) developed by Akar-Vural (2005) was used to measure their critical thinking attitudes. A Personal Information Form was used to get information about the students. As a result of the research, democratic attitudes of the students were found "very good" and their attitudes towards critical thinking were "good". According to the results of the regression analysis, it was determined that all the independent variables of the study predicted the students' democratic attitudes at the level of 17%. It was found that critical thinking attitude scores (2.7%), socioeconomic factors (6.5%), and academic success, television viewing and reading habits (7.5%) significantly predicted the students' democratic attitudes. Considering the regression coefficients, it was seen that gender, maternal education level and reading habits did not contribute significantly to predicting democratic attitudes.
Governmental policy capacity and policy work in a small place: Reflections on perceptions of civil servants in Prince Edward Island, Canada from a practitioner in the field

The body of public administration literature is missing contributions from practitioners in the field. Emic or insider-led studies of public administration can act as powerful mechanisms to generate new knowledge. This article studies the relationship between place, perceptions and policy work by drawing on the author’s own public administration experience and interviews with civil servants. The results show that societal factors such as political culture and reduced anonymity associated with small place create challenges when developing public policy. However, expedited public engagement and problem identification were perceived by civil servants to be enhanced by a small context. This means that small place can be both limiting and beneficial for high levels of policy capacity. Overall, this article finds that geospatial factors such as smallness impact perceptions of policy work and capacity. Furthermore, this article finds that insider-led studies of public administration can indeed make important and unique contributions to the body of literature and are therefore deserving of more serious methodological consideration.
Cytotoxic Effects of Hydroxy Coumarin Derivatives on Mouse Neuroblastoma N2a Cell Line

Neuroblastoma is one of the nervous system cancers, which approximately consists of 9% of childhood cancers. In this study, we evaluated the toxic effects of prenyl hydroxy coumarin derivatives on apoptosis of the neuroblastoma cell line N2A. N2A cells were cultured in DMEM medium, then the effects of different concentrations (0.75–200 μg/mL) of prenyl hydroxy coumarin derivatives during 24, 48, and 72 h were studied. Cell viability was quantified by MTT assay; apoptotic cells were determined using PI staining of DNA fragmentation through flow cytometry (sub-G1 peak). The toxic effect of 3farnesyl oxi coumarin in the N2A cell starts at 6.25 μg/ml and increases relatively depending on rising in concentration and over time. The toxicity and apoptosis of 3farnesyl and 6farnesyl oxi coumarin is more than 3Geranyl and 6-Geranyl oxi coumarin. Prenyl hydroxy coumarin induces peak sub-G1 in flow cytometry compared to the control group, indicating that induced toxicity, which is involved in apoptotic cell death. Different concentrations of derivatives (0.75-200 μg/mL) in lymphocytes did not induce any anti-proliferative effect in 24 h. In conclusion, prenyl hydroxy coumarin derivatives induce apoptotic effects in the N2A cell line. Then prenyl hydroxy coumarin derivatives sound to be chemotherapeutic agents for the neuroblastoma cancer cells.
Background Persistent antisocial behaviour is themostcommonmental health problemin childhood andhas widespread effects, yet little isknown

Declaration of interest None. Fundingdetailed in Acknowledgements. Persistent antisocial behaviour – a core feature of conduct disorder – substantially increases the likelihood of problems in adulthood such as violence, criminality, unstable relationships and mental health problems (Hill & Maughan, 2001). Forty per cent of children aged 7–8 years with conduct disorder become recidivist teenagers and over 90% of juvenile delinquents had conduct disorder as children (Scott, 1998). It is also a major predictor of lifetime resource use. Individuals with persistent antisocial behaviour at age 10 years cost society ten times as much as controls by the time they were 28 years old (Scott et al, 2001a; Knapp et al, 2002b). Although younger children with severe antisocial behaviour are likely to require support from a wide range of agencies (Knapp et al, 1999; Vostanis et al, 2003) little is known about the immediate, short-term costs in childhood. Lack of this information may be one reason why the mean annual spend in England and Wales on child and adolescent mental health is so low – about £10 per child per year (Audit Commission, 1999). The objectives of our study were to estimate the costs of supporting children with severe antisocial behaviour, to identify socio-demographic and clinical factors associated with those costs, and to gain further insight into who bears them.
A Two-Level Decomposition Framework Exploiting First and Second Order Information for SVM Training Problems

In this work we present a novel way to solve the sub-problems that originate when us-ing decomposition algorithms to train Support Vector Machines (SVMs). State-of-the-art Sequential Minimization Optimization (SMO) solvers reduce the original problem to a sequence of sub-problems of two variables for which the solution is analytical. Although considering more than two variables at a time usually results in a lower number of iterations needed to train an SVM model, solving the sub-problem becomes much harder and the overall computational gains are limited, if any. We propose to apply the two-variables decomposition method to solve the sub-problems themselves and experimentally show that it is a viable and eﬃcient way to deal with sub-problems of up to 50 variables. As a second contribution we explore diﬀerent ways to select the working set and its size, combining ﬁrst-order and second-order working set selection rules together with a strategy for exploiting cached elements of the Hessian matrix. An extensive numerical comparison shows that the method performs considerably better than state-of-the-art software.
Background Few studies have examined the relative risks of switching into hypomania ormania associatedwith second-generation antidepressantdrugs in bipolardepression. Aims To examine therelative acute effects of bupropion, sertraline and venlafaxine as adjuncts tomood

Declaration of interest None. Bipolar disorder occurs in 1–3% of the population (Angst & Sellaro, 2000; Akiskal et al, 2000). Despite naturalistic treatment in the community or intensive treatment at academic centres, patients remain symptomatic approximately half of the year, and the time depressed exceeds the time manic or hypomanic by a factor of three (Judd et al, 2002; Post et al, 2003a; Kupka et al, 2005). Bipolar disorder is potentially lethal, with a 10–20% lifetime risk of dying by suicide (Goodwin & Jamison, 1990). Despite these staggering human and public health statistics, there have been relatively few controlled studies of the use of antidepressants in the treatment of acute bipolar depression (Cohn et al, 1989; Himmelhoch et al, 1991; Young et al, 2000; Nemeroff et al, 2001) compared with numerous controlled trials in unipolar depression. There has been one moderately sized (n1⁄460) randomised, single-blind study comparing the efficacy of paroxetine and venlafaxine (Vieta et al, 2002) in bipolar depression. A small comparative trial by Sachs et al (1994) suggested that bupropion – which increases brain dopamine levels in the dorsal and ventral striatum upon acute and chronic administration (Nomikos et al, 1989, 1992) and also possesses some effects on noradrenaline – showed comparable acute efficacy to the noradrenergic tricyclic antidepressant desipramine, when added to ongoing treatment with a mood stabiliser for acute treatment of bipolar depression. However, the rate of switching into mania or hypomania on desipramine during acute and continuation treatment was considerably higher (37.5%) compared with bupropion (13.3%) (Guille et al, 1999). These data suggested the possibility that either the anticholinergic effects associated with the older tricyclic compounds in general or the potent selective effects of desipramine on noradrenaline reuptake could account for these differences. Gijsman et al (2004) in a meta-analysis found comparable efficacy but higher switch rates for tricyclic antidepressants compared with the newer antidepressants in acute trials for bipolar depression. Based on the early study of Sachs et al (1994), we predicted that the three antidepressants bupropion, sertraline and venlafaxine would achieve equal rates of response, but that venlafaxine (like desipramine) would show a higher rate of switching into hypomania or mania because of its additional noradrenergic effects. Consistent with the latter hypothesis, the study of Vieta et al (2002) found an increased rate of switching on venlafaxine (13.3%) in a single-blind, randomised comparison with paroxetine (3.0%) for 6 weeks in bipolar depression.
Experimental Study of the Possible Protective Effect of Alpha-Lipoic Acid on Paracetamol induced Oxidative Stress and Hepatic Toxicity in albino rats

Background: Paracetamol, is the most widely used over-the-counter analgesic and antipyretic medication in the world, which has minimal adverse effects at therapeutic dosages. But in high doses causes hepatic damage and oxidative stress. Objectives: The current study was designed to investigate paracetamol toxic effects upon the liver and oxidative stress after repeated oral dose and evaluate possible protective effect of alpha lipoic acid when co-administered with and after paracetamol. Methods: forty eight white albino rats were divided equally into four groups. Each group was subdivided into two sub groups A & B. Group I received gum acacia suspension. Group II received Alpha lipoic acid (50mg/kg) orally. Group III received paracetamol (1 gm/ kg orally) for 4 weeks. Group IV received paracetamol and alpha lipoic acid at the same doses. Sub groups A were euthanized after 4 weeks, while sub groups B were euthanized after 8 weeks. Blood was collected for evaluation of liver functions and oxidative stress marker. The livers were preserved for histopathological examinations. Results: The study proved that repeated administration of paracetamol induced disturbed liver functions and oxidative stress. But this toxic effects decline markedly when alpha lipoic acid (ALA) was coadministered with paracetamol. And more improvement occurs when ALA was administered for another 4 weeks after stoppage of paracetamol. Conclusions: The present study concluded that repeated paracetamol administration has hepatotoxic and oxidative stress effect and alpha lipoic acid has a protective effect against such harmful effects especially when ALA was administered for another 4 weeks after stoppage of paracetamol.