Miracle-dz/UniFAR-FTUs huggingface dataset:
Growth performance and nitrogen excretion of broiler chickens fed low protein diets supplemented with crystalline amino acids

This study was conducted to determine the effects of amino acid (AA) supplementation in low-protein (LP) diets on growth performance and nitrogen (N) excretion. A total of 175 7-day-old Ross 308 male broilers, with a mean body weight (BW) of 165 g (standard deviation = 11.2 g), were grouped into five blocks by BW and allocated to seven treatments according to a randomized complete block design with five replicate cages at five birds per cage. Dietary treatments comprised a control diet containing 20.0% crude protein (CP) and six LP diets containing either 18.5% or 17.0% CP. These LP diets were supplemented with either no AA supplementation, indispensable AA, or both indispensable and dispensable AA (glutamic acid and glycine). Birds were fed experimental grower diets from day 7 to 21 and then commercial finisher diets until day 28. During the grower period (day 7 to 21), birds fed LP diets supplemented with indispensable AA exhibited greater ( p < 0.05) BW, body weight gain (BWG), feed intake (FI), and gain-to-feed ratio (G:F) than birds fed LP diets without crystalline AA and were comparable to birds fed the control diet. During the finisher period (day 21 to 28), birds fed LP diets supplemented with indispensable AA showed greater ( p < 0.05) BW than birds fed LP diets without crystalline AA, and their growth performance was comparable to birds fed the control diet. Throughout the overall period, supplementing indispensable AA in LP diets resulted in elevated ( p < 0.05) BWG, FI, and G:F more than those of LP diets without crystalline AA and were comparable to those of the control diet. Supplementing indispensable AA in LP diets decreased amount and coefficient of N excretion as much as the control diet. Dispensable AA supplementation in LP diets did not influence growth performance and N excretion. In conclusion, supplementing indispensable AA in LP diets maintains growth performance and N excretion until the dietary CP lowers from 20.0% to 17.0% during the grower period. As long as dietary CP is above 17.0%, dispensable AA may not be deficient in LP diets during the grower period.
Gauging the Motivation Level of Health Personnel of a Tertiary Care Hospital in District Dehradun

Background- Healthcare providers serve as the backbone of the healthcare delivery system, and motivating them is crucial for its enhancement, which is often a challenging task. Understanding the motivational factors that keep employees engaged is a pressing concern for leaders and senior personnel. Aims & Objectives: This study aimed to assess the motivation levels of healthcare personnel working in a tertiary healthcare institution in Dehradun, Uttarakhand. It sought to explore the various factors influencing employee motivation in the healthcare sector. Methodology: A cross-sectional study involved 150 healthcare personnel, and data analysis was conducted using Statistical Package for Social Sciences (SPSS) software and Microsoft Excel. Frequency percentages and mean standard deviations were used for categorical and continuous data, respectively. The Chi-Square test and Fischer Exact test were employed to assess relationships between categorical variables. Results: Among the study groups, technicians displayed the highest motivation levels, while doctors exhibited lower motivational indices. Across doctors, nurses, and technicians, "rewards" ranked as the top motivating factor. Health personnel identified monetary support, incentives, promotion, resource improvement, appreciation, feedback, communication, job security, training, teamwork, and effective management as significant motivational factors. Conclusion: Satisfied healthcare workers not only inspire their colleagues but also foster a positive work environment, enhancing the overall functioning of the institution. Employee motivation directly impacts the performance of healthcare organizations. Recognizing non-financial motivators, such as appreciation, teamwork, professional growth, and training, alongside financial incentives, is essential to maintaining a motivated and efficient healthcare workforce.
Longitudinal Parameter Estimation Using Wind Tunnel and Simulated Flight Data of Missile Configuration

The present study makes an attempt to estimate aerodynamic parameters from a typical flight data of a short range missile. Exhaustive wind tunnel testing was conducted to generate longitudinal force and moment coefficients at low speed. Identification methods were applied on the selected wind tunnel data to capture the general form of the aerodynamic model. During the application of Maximum likelihood (ML) method, the estimation algorithm assumed this wind tunnel identified aerodynamic model to be exact. To avoid any requirement of postulation of aerodynamic model, the Delta method was applied to estimate the aerodynamic parameters. The Delta method used measured aircraft motion and control variables as the inputs to the Feed Forward Neural Network and the aerodynamic force or moment coefficient was the output for training the Feed Forward Neural Network. The application of the Delta method results in large scatters in the estimated parameters. To overcome this problem of large scatter, the Delta method was modified by changing the training strategy. The Delta method with new training strategy will be referred as the Modified Delta method. It is expected that the proposed Modified Delta method would result in estimates with less uncertainties. Further to check the robustness of the ML, Delta and the Modified delta methods, the estimation was also carried out with flight data having known measurement noise. The effect of control input form in the accuracy of estimates obtained by ML, the Delta and the Modified Delta methods are also studied. It is observed that the Modified Delta method can advantageously be applied on the flight data of a tactical missile to estimate aerodynamic parameters. The paper progresses with the description of the generation of wind tunnel data and aerodynamic model identification using selected wind tunnel data. Finally it concludes by demonstrating applicability of ML, the Delta and the Modified Delta methods on simulated flight data of a typical short range tactical missile configuration.
Genome-Wide Association Study of Arsenic Accumulation in Polished Rice

The accumulation of arsenic (As) in rice poses a significant threat to food safety and human health. Breeding rice varieties with low As accumulation is an effective strategy for mitigating the health risks associated with arsenic-contaminated rice. However, the genetic mechanisms underlying As accumulation in rice grains remain incompletely understood. We evaluated the As accumulation capacity of 313 diverse rice accessions grown in As-contaminated soils with varying As concentrations. Six rice lines with low As accumulation were identified. Additionally, a genome-wide association studies (GWAS) analysis identified 5 QTLs significantly associated with As accumulation, with qAs4 being detected in both of the experimental years. Expression analysis demonstrated that the expression of LOC_Os04g50680, which encodes an MYB transcription factor, was up-regulated in the low-As-accumulation accessions compared to the high-As-accumulation accessions after As treatment. Therefore, LOC_Os04g50680 was selected as a candidate gene for qAs4. These findings provide insights for exploiting new functional genes associated with As accumulation and facilitating the development of low-As-accumulation rice varieties through marker-assisted breeding.
Laboratory and Numerical Simulation of the Evolution of a River's Talik

Experiments simulating the evolution of a river talik were performed in a cold room where a small channel carried flowing water through frozen saturated porous soil in a hydraulic flume. The sensitivity of thaw propagation to water temperature and velocity was determined to indicate the relative importance of these controlling parameters. Two types of soils were investigated (sand and silty clay), corresponding to contrasting hydrological, thermal and mechanical behaviours. The experimental results show that the sensitivity to water temperature was much higher than that to water velocity for the ranges considered. The experiments were compared with results from one‐dimensional numerical simulations to identify the thermal boundary conditions of the riverbed and to evaluate the capacity of the numerical code to represent the propagation of heat at depth. The results showed that the proper boundary conditions are of the Neumann type, where flux is expressed as a coefficient multiplied by the temperature difference between water and the soil surface. The value of this coefficient is evaluated as a function of flow velocity based on these experiments. As a first‐order approximation, this coefficient is assumed to be constant when considering seasonal flow variations. Copyright © 2017 John Wiley & Sons, Ltd.
Diffusion-zoned pyroxenes in an isotopically heterogeneous mantle lithosphere beneath the Dunedin Volcanic Group, New Zealand, and their implications for intraplate alkaline magma sources

An important task in assessing the magma source of an intraplate volcanic province is establishing the composition of the underlying lithospheric mantle. Pyroxenes in peridotite xenoliths from the ∼10,000 km2 Dunedin Volcanic Group in New Zealand reveal that the underlying lithospheric mantle is chemically and isotopically heterogeneous and has a complex thermal history. Portions of this mantle have light rare earth element–depleted clinopyroxene trace element concentrations and distinctly radiogenic Nd compositions (eNd(20 Ma) ≥ + 15.5) with model depleted mantle ages that are ≥100 m.y. older than the overlying Jurassic crust (type 1). The Nd isotopic composition of these moderately fertile domains is distinct from any Dunedin Volcanic Group magma, but the domains are embedded within enriched peridotitic mantle (type 2) that has formed through reaction with a light rare earth element–rich fluid that imparted an isotopic composition in strongly metasomatized xenoliths of 87Sr/86Sr(20 Ma) = 0.7028–0.7029, eNd(20 Ma) = + 5.0 to + 5.1, and 206Pb/204Pb = 19.9, 207Pb/204Pb = 15.5, and 208Pb/204Pb = 39.6. These isotope ratios overlap with the isotopically homogeneous high time-integrated U/Pb–like source signature of the host Dunedin Volcanic Group. However, all metasomatic and nonmetasomatic pyroxenes are zoned in temperature-sensitive elements (Al, Cr, Mg ± Ca), with trends indicating element exchange during cooling and the results of diffusion calculations implying that the zoning formed over hundreds of thousands to millions of years prior to late Oligocene–Miocene xenolith entrainment. These data, along with calculated pyroxene rare earth element homogenization diffusion rates, indicate that mantle metasomatism predated entrainment in the host magmas by millions of years. Furthermore, the presence of the cooling trends in all but one sample indicates that this upper lithosphere mantle preserves little or no sign of a rise in the geotherm at the time of magmatism. Zoning patterns in peridotite pyroxenes can therefore provide useful insight into the role of portions of the lithospheric mantle in formation of intraplate alkaline basalts.
Risk Polymorphisms of FNDC5, BDNF, and NTRK2 and Poor Education Interact and Aggravate Age-Related Cognitive Decline

Cognitive abilities tend to decline with aging, with variation between individuals, and many studies seek to identify genetic biomarkers that more accurately anticipate risks related to pathological aging. We investigated the influence of BDNF, NTRK2, and FNDC5 single nucleotide polymorphisms (SNPs) on the cognitive performance of young and older adults with contrasting educational backgrounds. We addressed three questions: (1) Is education associated with reduced age-related cognitive decline? (2) Does the presence of SNPs explain the variation in cognitive performance observed late in life? (3) Is education differentially associated with cognition based on the presence of BDNF, NTRK2, or FNDC5 polymorphisms? We measured the cognitive functions of young and older participants, with lower and higher education, using specific and sensitive tests of the Cambridge Automated Neuropsychological Test Assessment Battery. A three-way ANOVA revealed that SNPs were associated with differential performances in executive functions, episodic memory, sustained attention, mental and motor response speed, and visual recognition memory and that higher educational levels improved the affected cognitive functions. The results revealed that distinct SNPs affect cognition late in life differentially, suggesting their utility as potential biomarkers and emphasizing the importance of cognitive stimulation that advanced education early in life provides.
What do people think about when they answer the Brief Illness Perception Questionnaire ?

What do people think about when they answer the Brief Illness Perception Questionnaire? A ‘think-aloud’ study L. van Oort1,2∗, C. Schröder3,4 and D. P. French5 1Academy of Physiotherapy, AVANS University of Applied Sciences, Breda, The Netherlands 2Primary Care Physiotherapy Practice, ‘Bloemsaat & Van Beek’, Raamsdonksveer, The Netherlands 3SOMT, Institute for Master Education in Manual Therapy, Amersfoort, The Netherlands 4Rehabilitation centre ‘de Hoogstraat’, Utrecht, The Netherlands 5Applied Research Centre in Health and Lifestyle Interventions, Coventry University, UK
Impact of Baizhu, Daqingye, and Hehuanhua extracts on the human gut microbiome

Introduction In traditional Chinese medicine, the rhizome of Atractylodes macrocephala (Baizhu), the leaves of Isatis indigotica (Daqingye), and the flowers of Albizia julibrissin (Hehuanhua) have been used to treat gastrointestinal illnesses, epidemics, and mental health issues. Modern researchers are now exploring the underlying mechanisms responsible for their efficacy. Previous studies often focused on the impact of purified chemicals or mixed extracts from these plants on cells in tissue culture or in rodent models. Methods As modulation of the human gut microbiome has been linked to host health status both within the gastrointestinal tract and in distant tissues, the effects of lipid-free ethanol extracts of Baizhu, Daqingye, and Hehuanhua on the human adult gut microbiome were assessed using Systemic Intestinal Fermentation Research (SIFR®) technology (n=6). Results and discussion Baizhu and Daqingye extracts similarly impacted microbial community structure and function, with the extent of effects being more pronounced for Baizhu. These effects included decreases in the Bacteroidetes phylum and increases in health-related Bifidobacterium spp. and short chain fatty acids which may contribute to Baizhu’s efficacy against gastrointestinal ailments. The changes upon Hehuanhua treatment were larger and included increases in multiple bacterial species, including Agathobaculum butyriciproducens, Adlercreutzia equolifaciens, and Gordonibacter pamelaeae, known to produce secondary metabolites beneficial to mental health. In addition, many of the changes induced by Hehuanhua correlated with a rise in Enterobacteriaceae spp. , which may make the tested dose of this herb contraindicated for some individuals. Overall, there is some evidence to suggest that the palliative effect of these herbs may be mediated, in part, by their impact on the gut microbiome, but more research is needed to elucidate the exact mechanisms.
The interaction between past and conditional morphemes in Turkish

This paper focuses on the two conditional antecedent morphemes in Turkish, -(y)sA and -sA, and how the past morpheme interacts with them to generate different interpretations. Inspired by von Fintel and Iatridou (2023), I refer to -(y)sA as the O-marking, which is restricted to the epistemically possible worlds, and -sA as the X-marking, which refers to a wider domain than this context set. I argue that the past in O-marking denotes the actual past time. However, when the past morpheme appears with X-marking, it further widens the domain to include even less possible or impossible worlds. In line with Kaufmann (2022), I also argue for different levels of remoteness in X-marked conditionals and suggest that the past widens the domain further than the first level of X-marking by shifting back in time as she suggests.
Exosomal Cargo in Ovarian Cancer Dissemination

Ovarian cancer (OC) has the highest mortality rate among all gynecologic cancers and is characterized by early peritoneal spread. The growth and development of OC are associated with the formation of ascitic fluid, creating a unique tumor microenvironment. Understanding the mechanisms of tumor progression is crucial in identifying new diagnostic biomarkers and developing novel therapeutic strategies. Exosomes, lipid bilayer vesicles measuring 30–150 nm in size, are known to establish a crucial link between malignant cells and their microenvironment. Additionally, the confirmed involvement of exosomes in carcinogenesis enables them to mediate the invasion, migration, metastasis, and angiogenesis of tumor cells. Functionally active non-coding RNAs (such as microRNAs, long non-coding RNAs, circRNAs), proteins, and lipid rafts transported within exosomes can activate numerous signaling pathways and modify gene expression. This review aims to expand our understanding of the role of exosomes and their contents in OC carcinogenesis processes such as epithelial-mesenchymal transition (EMT), angiogenesis, vasculogenic mimicry, tumor cell proliferation, and peritoneal spread. It also discusses the potential for utilizing exosomal cargo to develop novel “liquid biopsy” biomarkers for early OC diagnosis.
Loss of Cdc42 in Exocrine Acini Decreases Saliva Secretion but Increases Tear Secretion—A Potential Model of Exocrine Gland Senescence

Cdc42 is a small GTPase essential for the cell cycle, morphogenesis, and cell adhesion, and it is involved in the polarity of epithelial cells. However, the functional roles of Cdc42 in exocrine glands, such as the maintenance of acini and water secretion, are not yet well understood. In this study, we generated acinar-cell-specific Cdc42 conditional knockout (Cdc42cKO) mice to assess their maintenance of acinar cells and physiological functions in the salivary glands (SGs) and lacrimal glands (LGs). Our data revealed that the loss of Cdc42 altered the luminal structures to bulging structures and induced acinar cell apoptosis in both the parotid glands (PGs) and LGs of Cdc42cKO mice. Interestingly, saliva secretion in response to pilocarpine stimulation was decreased in the Cdc42cKO group, whereas tear secretion was increased. Consistent with the water secretion results, protein expression of the water channel AQP5 in acinar cells was also decreased in the PGs but conversely increased in the LGs. Moreover, the changes that increased AQP5 expression in LGs occurred in the acinar cells rather than the duct cells. The present study demonstrates that Cdc42 is involved in the structural and survival maintenance of acinar cells in SGs and LGs. On the other hand, depletion of Cdc42 caused the opposite physiological phenomena between PGs and LGs.
Les mysidacés suprabenthiques de la marge sud du canyon du Cap-Ferret (Golfe de Gascogne) : répartition bathymétrique et activité natatoire

Presentation des 1ers resultats sur les communautes suprabenthiques bathyales de la marge sud du canyon du Cap Ferret, a partir de la taxocenose des Mysidaces. Les prelevements ont ete effectues entre -350 et -1100 m avec un traineau de type MACER-GIROQ modifie permettant l'echantillonnage simultane et etage de 4 niveaux compris entre 0,10 et 1,45 au dessus du fond. A l'aide d'une analyse factorielle de correspondances, 3 groupes faunistiques ont ete identifies
AUTHENTIC DEED OF AUTHORITY TO SELL INDEPENDENTLY IN MAKING A DEED OF SALE AND PURCHASE

The Deed of Authority to Sell Independently is akin to a power of attorney, which grants someone the authority to act on another's behalf. In land transfers, this authorization must be made before a Notary, a public official responsible for authentic deeds and their validity, including providing copies and excerpts as per Article 15 paragraph (1) of UUJN. The purpose of this study was to study the process of making a Deed of Sale and Purchase deed using an Authentic Deed of Authority to Sell Independently and registration of the transfer of land rights based on an Authentic Deed of Authority to Sell Independently at the Land Office. The research method used is the normative research method. The results of this study showed that the Authentic Deed of Authority to Sell Independently can be used in making a sale and purchase deed if it meets the specified conditions. In addition, the Authentic Deed of Authority to Sell Independently can also be used in registering the transfer of land rights at the Land Office.
Chronology and processes of late Quaternary hillslope sedimentation in the eastern South Island, New Zealand

Optical and radiocarbon dating of loessic hillslope sediments in New Zealand's South Island is used to constrain the timing of prehistoric rockfalls and associated seismic events, and quantify spatial and temporal patterns of hillslope sedimentation including responses to seismic and anthropogenic forcing. Trenches adjacent to prehistoric boulders enable stratigraphic analysis of loess and loess‐colluvium pre‐ and post‐dating boulder emplacement, respectively. Luminescence ages from loessic sediments constrain the timing of boulder emplacement to between ∼3.0 and ∼12.5 ka, well before the arrival of Polynesians (ca. AD 1280) and Europeans (ca. AD 1800) in New Zealand, and suggest loess accumulation was continuing at the study site until 12–13 ka. Large (>5 m3) prehistoric rockfall boulders preserve an important record of Holocene hillslope sedimentation by creating local traps (i.e. accommodation space) for sediment aggradation (i.e. colluvial wedges) and upbuilding soil formation. Sediment accumulation rates increased considerably (>∼10 factor increase) following human arrival and associated anthropogenic burning of hillslope vegetation. Our study presents new numerical ages to place the evolution of loess‐mantled hillslopes in New Zealand's South Island into a longer temporal framework and highlights the roles of earthquakes and humans on hillslope surface process.
Early Cretaceous synrift uplift and tectonic inversion in the Loppa High area, southwestern Barents Sea, Norwegian shelf

Tectonic inversion of rift basins is most commonly reported in the literature to occur after rifting has ceased. In contrast, we present evidence for synrift, localized tectonic inversion from the Loppa High area, southwestern Barents Sea and present a model for the formation of inversion structures as a result of differential uplift. The structures are of early Barremian to mid-Albian age (c. 131 – 105 Ma) and are focused in or near pre-existing extensional boundary faults along the margins of the Loppa High. Inversion is interpreted to be the result of uplift of the high along its inclined boundary faults, leading to space accommodation problems as uplift was not properly compensated by extension in the region. The model constrains the initiation of uplift of the Loppa High to the early Barremian and shows that the asymmetric margin configuration of the high may have led to a bulk clockwise rotation of the high around a vertical axis during uplift. The cause of uplift is not fully understood, but is suggested to be linked to contemporaneous extreme lithospheric thinning in neighbouring basins to the west. Processes involved may include isostatic flexure, thermal heating, lithological phase changes and/or far-field stresses, although these aspects need to be further tested.