Miracle-dz/UniFAR-FTUs huggingface dataset:
Progressive Ataxia and Palatal Tremor Showing Characteristic Tau Depositions in [18F]PM‐PBB3 PET

Progressive ataxia and palatal tremor (PAPT) are slowly progressive neurodegenerative diseases characterized by progressive ataxia and palatal tremor, which has been described as a novel tauopathy based on neuropathological findings. The novel tau positron emission tomography (PET) tracer [F]PM-PBB3 could detect 3and 4-repeat tau deposits with high contrast in non-Alzheimer’s disease tauopathies. Here, we report the first case of PAPT in which ante-mortem evaluations of tau retention were made using [F]PM-PBB3. A 65-year-old Japanese male became aware of gait disturbance and visited our hospital. Neurological examination showed mild dysarthria, 2to 3-Hz palatal tremor, saccadic eye movements, mild upper limb ataxia, and mild ataxic gait, but no vertical gaze palsy or parkinsonism (Video S1). Brain magnetic resonance imaging (MRI) demonstrated T2 hyperintensities in bilateral inferior olivary nuclei (IONs) and mild cerebellar atrophy (Fig. 1A,B). Dopamine transporter scintigraphy showed normal uptake in striatum. We performed [F]PM-PBB3 tau PET for evaluating tau deposits. Regional standardized uptake value ratios (SUVRs) were calculated using the occipital area as a reference because it is known to carry low tau burdens in PAPT. Strong [F]PM-PBB3 retentions were observed in the pons and dentate nucleus (DN), and moderate retention in red nucleus (RN) and cerebellum, which are components of Guillain-Mollaret triangle (GMT). These
Dexamethasone, Prednisolone, and Methylprednisolone Use and 2-Year Neurodevelopmental Outcomes in Extremely Preterm Infants

Key Points Question What are the patterns of dexamethasone and prednisolone and methylprednisolone use in extremely preterm infants and are their use associated with 2-year outcomes? Findings In this cohort study including 828 extremely preterm infants from a multicenter randomized clinical trial, 38% of infants were treated with corticosteroids, with exposure rates decreasing as gestational age at birth increased. More infants were treated with dexamethasone, and exposure was shorter and earlier compared with prednisolone or methylprednisolone; longer duration of treatment with dexamethasone, but not prednisolone or methylprednisolone, was associated with worse neurodevelopmental outcomes at corrected age 2 years. Meaning These findings suggest that significant practice variation in postnatal corticosteroids treatment was common and that limiting exposure to dexamethasone may be associated with minimizing adverse neurodevelopmental outcomes.
Agreement Between Sagittal Foot and Tibia Angles During Running Derived From an Open-Source Markerless Motion Capture Platform and Manual Digitization.

Several open-source platforms for markerless motion capture offer the ability to track 2-dimensional (2D) kinematics using simple digital video cameras. We sought to establish the performance of one of these platforms, DeepLabCut. Eighty-four runners who had sagittal plane videos recorded of their left lower leg were included in the study. Data from 50 participants were used to train a deep neural network for 2D pose estimation of the foot and tibia segments. The trained model was used to process novel videos from 34 participants for continuous 2D coordinate data. Overall network accuracy was assessed using the train/test errors. Foot and tibia angles were calculated for 7 strides using manual digitization and markerless methods. Agreement was assessed with mean absolute differences and intraclass correlation coefficients. Bland-Altman plots and paired t tests were used to assess systematic bias. The train/test errors for the trained network were 2.87/7.79 pixels, respectively (0.5/1.2 cm). Compared to manual digitization, the markerless method was found to systematically overestimate foot angles and underestimate tibial angles (P < .01, d = 0.06-0.26). However, excellent agreement was found between the segment calculation methods, with mean differences ≤1° and intraclass correlation coefficients ≥. 90. Overall, these results demonstrate that open-source, markerless methods are a promising new tool for analyzing human motion.
Influence of biochar on the sorption and leaching of thiamethoxan in soil

Abstract This study evaluated the long-term effect of biochar application on the sorption and desorption of thiamethoxam in a Haplic Plinthosol. The experiment was conducted in a randomized block design with combination of doses of mineral fertilizer NPK (0 and 300 kg·ha−1 formula 05-25-15) and biochar (0, 16 and 32 Mg ha−1). Deformed soil samples were collected in the field from the 0-0.10 m layer of all plots to determine the sorption and desorption of the thiamethoxam insecticide in the soil; fulvic acid (FA), humic acid (AH) and humin (HUM) carbon contents; and total organic carbon. The Batch slurry method was used to evaluate sorption and desorption. The Freundlich isotherm adequately described thiamethoxam sorption in all treatments. The application of biochar increased the sorption (Kfs) and decreased the desorption (Kfd) of thiamethoxam. The sorption intensity (1/n) showed reduction characteristics as the soil concentration of thiamethoxam increased. Biochar has a sorption effect on the soil through covalent bonds and H-bonds with the insecticide molecules, thereby indirectly increasing the sorption potential in the chemical fractions of the organic matter of soil. The application of 32 Mg ha−1 of biochar significantly reduced thiamethoxam in the soil solution. Altogether, the present study reveals that biochar application in soil is a promising tool for mitigating the contaminant potential of thiamethoxam in subsurface waters.
The clinical and neuropathological picture of adult neuronal intranuclear inclusion disease with no radiological abnormality

In typical adult neuronal intranuclear inclusion disease (NIID) with predilection for the basal ganglia or cerebral cortex, not only neurons but also glial cells harbor intranuclear inclusions. In addition, these inclusions are present in the peripheral autonomic nervous system, visceral organs and skin. In NIID cases with an expansion of GGC repeats in the 5′‐untranslated region (5′‐UTR) of the Notch 2 N‐terminal like C (NOTCH2NLC) gene, these repeats are located in an upstream open reading frame (uN2C) and result in the production of a polyglycine‐containing protein called uN2CpolyG. Typically, patients with adult NIID show high‐intensity signals at the corticomedullary junction on diffusion‐weighted brain magnetic resonance imaging. We report a case of adult NIID in a 78‐year‐old Japanese male, who suffered from mild, non‐progressive tremor during life but showed no radiographic abnormalities suggestive of adult NIID. Pathologically, ubiquitin‐, p62‐ and uN2CpolyG‐positive neuronal intranuclear inclusions were particularly frequent in the hippocampal formation, but were also seen in the enteric plexuses, kidney and cardiac muscles. By contrast, glial intranuclear inclusions were barely evident in the affected regions. The present case also had an immunohistochemical profile differing from that of typical adult NIID. The findings in this case suggest that adult NIID can show clinical, radiographic and pathological heterogeneity.
Cohabitation with a smoker and efficacy of cessation programmes: the mediating role of the theory of planned behaviour

Abstract Objective The present research sought to examine whether cohabitation with a smoker undermines smoking cessation among people engaged in a cessation programme and whether the components of the Theory of Planned Behaviour (TPB) act as mediating mechanisms. Design A prospective longitudinal study with online questionnaires was conducted among smokers living in Switzerland who enrolled in a 6-months smoking cessation programme. Main outcome measures Cohabitation with a smoker and the TPB constructs were assessed 10 days after the start of the programme (T1; N = 820). Smoking abstinence was measured at T1, and at 3-months (T2; N = 624) and 6-months follow-ups (T3; N = 354). Results Results showed that living with a smoker decreased the odds that smokers remained abstinent throughout the cessation programme. Furthermore, we found that cohabitation was negatively associated with subjective norm. Afterwards, subjective norm predicted intention to maintain smoking cessation, which, in turn, predicted smoking abstinence. Such mediation effects persisted at each time point. Conclusion The present research provided evidence that living with other smokers at home can lead to greater risks of relapsing among people engaged in a cessation programme. We discussed the role of smoking-related norms in the efficacy of cessation interventions. Supplemental data for this article is available online at https://doi.org/10.1080/08870446.2022. 2041638 .
Autism spectrum disorder and paediatric dentistry: A narrative overview of intervention strategy and introduction of an innovative technological intervention method.

AIM When treating patients with Autism Spectrum Disorder (ASD) the doctor-patient relationship can be very challenging. The dentist is often forced to work under general anaesthesia or conscious sedation. Children with ASD are patients with an increased risk of caries due to poor oral hygiene, a cariogenic diet and the use of xerostomal drugs. In this work therapeutic strategies used to treat this kind of patients are evaluated and a new method to treat children with ASD is presented in order to increase awareness about this condition in the dental field. METHODS The Atlas Center (a non-profit organisation in Peurgia, Italy) has developed a software, called paINTeraction, that allows these special children to immerse themselves in a virtual reality with the help of an operator. Through this system the child can explore the dental office (and all its sounds and noises) before the real dental visit, thus connecting to the dental professional, achieving greater compliance and reducing anxiety. CONCLUSION paINTeraction, with the use of digital technology tools, may be particularly well suited to introduce patients to the therapeutic environment, particularly in the dental setting.
Correlation between global prevalence of vision impairment and depressive disorders

Purpose To assess the correlation of the worldwide prevalence of visual impairment and depressive disorders. Methods This is an ecologic study on Global Burden of Disease 2019 data. Global and national prevalence numbers and rates of vision impairment (VI) and depressive disorders were obtained from database. The human development index (HDI) and socio-demographic index (SDI) were derived from international open databases. Main outcome measures were the correlation of the VI and depressive disorders in total and different age, sex, and socioeconomic subgroups. Results In 2019, the worldwide prevalence of total VI and total depressive disorders were 9.6% (95% Uncertainty Interval (UI): 8.0–11.3) and 3.8% (95% UI: 3.4-4.2), respectively. The prevalence rates of total VI (r = 0.38, P < 0.001) as well as cataract (r = 0.43, P < 0.001), age-related macular degeneration (AMD) (r = 0.32, P < 0.001), refractive disorders (r = 0.19, P < 0.001) and near vision loss (r = 0.33, P < 0.001) correlated, positively, with dysthymia. In addition, the prevalence rates of glaucoma (r for total depressive disorders = 0.37, P < 0.001 and r for major depressive disorders (MDD) = 0.38, P < 0.001) and AMD (r for total depressive disorders = 0.37, P < 0.001 and r for MDD = 0.28, P < 0.001) had a positive correlation with MDD and total depressive disorders. The correlations remained significant in sociodemographic subgroups. Conclusion There was a significant correlation between national prevalence rates of VI and ocular disabilities with depressive disorders, worldwide.
Can a fast thinker be a good thinker? The neural correlates of base-rate neglect measured using a two-response paradigm

ABSTRACT Traditionally, it has been assumed that logical thinking requires deliberation. However, people can also make logical responses quickly, exhibiting logical intuitions. We examined the neural correlates of logical intuitions by administering base rate problems during fMRI scanning using a two-response paradigm where participants first responded quickly and then reflectively to problems that did or did not pit a normative response against an intuitively-cued stereotypical response (i.e., conflict vs. non-conflict problems). As predicted, participants were less likely to make judgments in accordance with base rates on conflict problems. Critically, in only 4% of cases did longer deliberation change an initially biased response to a normatively correct response. The fMRI data revealed that intuitively-made initial biased judgments nevertheless activate regions typically involved in cognitive control, executive functions and attention, including anterior, inferior, middle and superior frontal cortex, suggesting that even when errors are made, there might be very early awareness of conflict.
Guidelines for diagnosis and treatment of depression in older adults: A report from the Japanese Society of mood disorders

The Committee for Treatment Guidelines of Mood Disorders, Japanese Society of Mood Disorders, published a Japanese guideline for the treatment of late‐life depression in 2020. Based on that guideline, the present guideline was developed and revised to incorporate the suggestions of global experts and the latest published evidence. In the diagnosis of late‐life depression, it is important to carefully differentiate it from bipolar disorders, depressive states caused by physical and organic brain disease, drug effects, and dementia, and to determine the comorbidity between late‐life depression and dementia. It is necessary to fully understand the clinical characteristics and psychosocial background of late‐life depression, evaluate the patient's condition, and provide basic interventions based on these factors. Problem‐solving therapy, reminiscence therapy/life review therapy, and behavioral activation therapy, and other forms of psychotherapy can reduce depressive symptoms. In terms of pharmacotherapy, newer antidepressants or non‐tricyclic antidepressants are recommended for late‐life depression, and it is recommended that the efficacy of least the minimal effective dosage should first be determined. Switching antidepressants and aripiprazole augmentation can be used to treatment‐resistant therapy. Electroconvulsive therapy and repetitive transcranial magnetic stimulation have demonstrated usefulness for late‐life depression. Exercise therapy, high‐intensity light therapy, and diet therapy also show some effectiveness and are useful for late‐life depression. Continuation therapy should be maintained for at least 1 year after remission.
Metabolomics as a tool for the early diagnosis and prognosis of diabetic kidney disease

Diabetic kidney disease (DKD) is one of the most prevalent comorbidities of diabetes mellitus and the leading cause of the end‐stage renal disease (ESRD). DKD results from chronic exposure to hyperglycemia, leading to progressive alterations in kidney structure and function. The early development of DKD is clinically silent and when albuminuria is detected the lesions are often at advanced stages, leading to rapid kidney function decline towards ESRD. DKD progression can be arrested or substantially delayed if detected and addressed at early stages. A major limitation of current methods is the absence of albuminuria in non‐albuminuric phenotypes of diabetic nephropathy, which becomes increasingly prevalent and lacks focused therapy. Metabolomics is an ever‐evolving omics technology that enables the study of metabolites, downstream products of every biochemical event that occurs in an organism. Metabolomics disclosures complex metabolic networks and provide knowledge of the very foundation of several physiological or pathophysiological processes, ultimately leading to the identification of diseases' unique metabolic signatures. In this sense, metabolomics is a promising tool not only for the diagnosis but also for the identification of pre‐disease states which would confer a rapid and personalized clinical practice. Herein, the use of metabolomics as a tool to identify the DKD metabolic signature of tubule interstitial lesions to diagnose or predict the time‐course of DKD will be discussed. In addition, the proficiency and limitations of the currently available high‐throughput metabolomic techniques will be discussed.
Evaluation of Serologic Cross-Reactivity Between Dengue Virus and SARS-CoV-2 in Patients with Acute Febrile Illness — United States and Puerto Rico, April 2020–March 2021

The diagnosis of dengue disease, caused by the dengue virus (DENV) (a flavivirus), often requires serologic testing during acute and early convalescent phases of the disease. Some symptoms of DENV infection, such as nonspecific fever, are similar to those caused by infection with SARS-CoV-2, the virus that causes COVID-19. In studies with few COVID-19 cases, positive DENV immunoglobulin M (IgM) results were reported with various serologic tests, indicating possible cross-reactivity in these tests for DENV and SARS-CoV-2 infections (1,2). DENV antibodies can cross-react with other flaviviruses, including Zika virus. To assess the potential cross-reactivity of SARS-CoV-2, DENV, and Zika virus IgM antibodies, serum specimens from 97 patients from Puerto Rico and 12 U.S.-based patients with confirmed COVID-19 were tested using the DENV Detect IgM Capture enzyme-linked immunosorbent assay (ELISA) (InBios International). * In addition, 122 serum specimens from patients with confirmed dengue and 121 from patients with confirmed Zika virus disease (all from Puerto Rico) were tested using the SARS-CoV-2 pan-Ig Spike Protein ELISA (CDC). † Results obtained for DENV, Zika virus IgM, and SARS-CoV-2 antibodies indicated 98% test specificity and minimal levels of cross-reactivity between the two flaviviruses and SARS-CoV-2. These findings indicate that diagnoses of dengue or Zika virus diseases with the serological assays described in this report are not affected by COVID-19, nor do dengue or Zika virus diseases interfere with the diagnosis of COVID-19.
Morphological and Molecular Identification of Cimex hemipterus Fabricius, 1803 (Hemiptera: Cimicidae) and First Report of C. lectularius Linnaeus, 1758, in Madagascar

Abstract Bed bugs are hematophagous insects with a long history of presence in human communities. Over the last three decades, infestations by bed bugs in human dwellings have drastically increased, leading to a rise in bed bug concerns. This study was conducted in May 2019 in the Miarinarivo district of Madagascar. Eight locations with suspected infestations were inspected. Of these, five locations were found with active bed bug infestations. Overall, 23 (19 adults and four nymphs) specimens with numbers per apartment ranging from 2 to 6 were collected and analyzed using morphological and molecular approaches. Of 19 adults collected, 18 were morphologically identified as Cimex hemipterus (Hemiptera: Cimicidae), with the final adult identified as C. lectularius. Morphological identification of adults was confirmed by sequencing 450 bp fragment of COI gene. All four nymphs were also identified molecularly as C. hemipterus. Maximum likelihood phylogenetic tree of COI gene and sequence alignment of C. hemipterus specimens revealed the presence of two groups (first group clustered with previously reported haplotype from Asian and African countries and the second group encompassed a lesser known haplotype exclusively from Africa (Kenya and Senegal). This study presents low genetic diversity among C. hemipterus specimens and, for the first time, reports the occurrence of C. lectularius, known as temperate species, in Madagascar. These results can be helpful in control management strategies against these ectoparasites in this country.
Growth factors‐based platelet lysate rejuvenates skin against ageing through NF‐κB signalling pathway: In vitro and in vivo mechanistic and clinical studies

Platelets benefit tissue regeneration by secreting growth factors, and platelet products, for example, platelet lysate (PL), have been clinically applied for tissue rejuvenation. To determine the anti‐ageing efficacy and mechanism of human PL (hPL) on skin, this study conducted clinical retrospective analysis, nude mice‐based in vivo study and human dermal fibroblasts (HDFs)‐based in vitro study.
Increased precipitation and nitrogen addition accelerate the temporal increase in soil respiration during 8‐year old‐field grassland succession

Ecological succession after disturbance plays a vital role in influencing ecosystem structure and functioning. However, how global change factors regulate ecosystem carbon (C) cycling in successional plant communities remains largely elusive. As part of an 8‐year (2012–2019) manipulative experiment, this study was designed to examine the responses of soil respiration and its heterotrophic component to simulated increases in precipitation and atmospheric nitrogen (N) deposition in an old‐field grassland undergoing secondary succession. Over the 8‐year experimental period, increased precipitation stimulated soil respiration by 11.6%, but did not affect soil heterotrophic respiration. Nitrogen addition increased both soil respiration (5.1%) and heterotrophic respiration (6.2%). Soil respiration and heterotrophic respiration linearly increased with time in the control plots, resulting from changes in soil moisture and shifts of plant community composition from grass–forb codominance to grass dominance in this old‐field grassland. Compared to the control, increased precipitation significantly strengthened the temporal increase in soil respiration through stimulating belowground net primary productivity. By contrast, N addition accelerated temporal increases in both soil respiration and its heterotrophic component by driving plant community shifts and thus stimulating soil organic C. Our findings indicate that increases in water and N availabilities may accelerate soil C release during old‐field grassland succession and reduce their potential positive impacts on soil C accumulation under future climate change scenarios.
A review of the efficacy of easily accessible dry decontaminants for human chemical contamination

Soap and water are often considered the gold standard for dermal decontamination. However, recent systematic reviews have shown that these methods often result in incomplete decontamination and may even induce contaminant absorption due to the “wash‐in” effect. Therefore, it is important to gain insight on other decontamination methods. A literature search was done using PubMed to find experimental studies relating to dry decontamination performed with readily available items. Seven studies met eligibility criteria, and the study model, dry decontaminant, method of dry decontamination, method of analyzing decontamination, and main conclusions from each study were extracted, summarized, and compared. Important conclusions include that all studies investigated found that dry decontamination yielded decreases in contamination. In addition, it was shown by multiple studies that not only the decontaminant, but the manner in which it is used (method used [blotting, rubbing, etc.], amount used, and whether decontamination instructions are provided to exposed individuals) is vital to success. Finally, in all four studies that investigated wet and dry decontamination combination protocols, combinations were more efficacious than dry decontamination alone. However, this means that dry improvised decontamination can be performed while waiting for the deployment and arrival of further formal decontaminants. These conclusions deserve consideration in the event that universal decontamination guidelines are designed. However, more studies are required in order to draw definitive conclusions regarding the important topic of dermal decontamination.