Miracle-dz/UniFAR-FTUs huggingface dataset:
Neutron-capture element deficiency of the Hercules dwarf spheroidal galaxy

We present an assessment of the barium abundance ratios for red giant member stars in the faint Hercules dwarf spheroidal (dSph) galaxy. Our results are drawn from intermediate-resolution FLAMES/GIRAFFE spectra around the Ba II 6141.71 angstrom absorption line at low signal-to-noise ratios. For three brighter stars we were able to gain estimates from direct equivalent-width measurements, while for the remaining eight stars only upper limits could be obtained. These results are investigated in a statistical manner and indicate very low Ba abundances of log epsilon(Ba) less than or similar to 0.7 dex (3 sigma). We discuss various possible systematic biasses, first and foremost, a blend with the Fe I 6141.73 angstrom-line, but most of those would only lead to even lower abundances. A better match with metal-poor halo and dSph stars can only be reached by including a large uncertainty in the continuum placement. This contrasts with the high dispersions in iron and calcium (in excess of 1 dex) in this galaxy. While the latter spreads are typical of the very low luminosity, dark-matter dominated dSphs, a high level of depletion in heavy elements suggests that chemical enrichment in Hercules was governed by very massive stars, coupled with a very low star formation efficiency. While very low abundances of some heavy elements are also found in individual stars of other dwarf galaxies, this is the first time that a very low Ba abundance is found within an entire dSph over a broad metallicity range. (Less)
Toxicities From Antibody-Drug Conjugates

Abstract Antibody-drug conjugates are becoming increasingly important in the treatment of many cancer types. The 3 main structural components—antibody, linker, and payload—each contribute to the toxicity profiles of these drugs. In addition to cytopenias and gastrointestinal adverse effects attributed to the chemotherapy payloads, each drug has specific toxicities that are not commonly described in oncology. Ocular, pulmonary, dermatologic, and neurologic toxicities are particularly nuanced. This review provides a framework for clinicians to analyze current and future antibody-drug conjugates and a description of the unique monitoring, preventive, and supportive care measures for these agents.
p53 Expression in Breast Carcinoma and Its Association with Tumor Aggressiveness

Background: p53 mutations are the most frequent genetic alterations in breast cancer, observed in 30% of breast carcinomas. Their distribution is highly linked to molecular subtypes. Aim: The aim of the study was to establish an association between p53expression with various tumor variables such as age, histological grade, molecular subtypes, ki67, and Nottingham prognostic index (NPI). Materials and Methods: This was a cross-sectional analysis in VSSIMSAR, Burla, Odisha, India, from November 2015 to October 2017. Immunohistochemical study was done using DAKO primary antibody for estrogen receptors, progesterone receptors, human epidermal growth factor receptor (HER2/neu), Ki-67, and p53. Results: A total number of 62 cases were studied. p53 was positive in 10 (55.6%) cases of T2 tumors, 15 (60%) cases of T3 tumors, and 13 (76.5%) cases of T4 tumors. Among 26 basal-like tumors, 16 (61.5%) were p53 positive. In 12 HER2 enriched tumors, 10 (83.3%) were p53 positive, and in 8 luminal B tumors, only 2 (25%) cases came out to be p53 positive. p53 expression has a very significant association with lymph node metastasis (P < 0.01). p53 positivity increases with higher histological grades, and its reactivity is significantly associated with Ki-67 expression (P < 0.05) and NPI (P < 0.01). Conclusion: p53 association is mostly associated with more adverse phenotype and worse overall survival. There is an increased interest in p53 based therapy.
Risk Factors for 30-Day Mortality in Neonates With Carbapenem-resistant A. baumannii Sepsis

Background: Carbapenem-resistant Acinetobacter baumannii (CRAB) sepsis is becoming an extreme threat caused by high-case fatality rates and poor prevention and control in ICUs worldwide. However, the risk of mortality among neonatal CRAB sepsis is still unclear. Methods: A retrospective medical records review study, which aimed to identify the risk factors of mortality in neonates with CRAB sepsis (including both bacteremia and/or meningitis) in Thailand from 1996 to 2019. All cases featuring positive blood and cerebrospinal fluid cultures for CRAB were reviewed. A multivariable logistic regression model was analyzed for nonsurvivors and survivors of neonatal CRAB sepsis. Results: In a 24-year period, 47 of these were identified with CRAB sepsis. The median (interquartile range) gestational age and birth weight were 30 (28–35) weeks and 1500 (933–2482) g, respectively. The 30-day case fatality rate was 55% (26/47). In multivariable analysis, nonsurvivors of neonatal CRAB sepsis were associated with congenital heart disease (adjusted odds ratio [OR] = 1.33; 95% CI 1.06–1.66, P = 0.02), CRIB II score ≥9 (adjusted OR = 1.65; 95% CI: 1.20–2.27, P = 0.004), severe thrombocytopenia (adjusted OR = 1.45; 95% CI: 1.09–1.94, P = 0.02), and septic shock (adjusted OR = 1.62; 95% CI: 1.33–1.99, P <0.001). Conclusion: The risk factors of mortality in neonates with CRAB sepsis are associated with congenital heart disease, CRIB II score ≥9, shock, and severe thrombocytopenia.
Antibody Drug Conjugates in Lung Cancer

Abstract An antibody-drug conjugate (ADC) comprises a monoclonal antibody that is specific to a tumor cell protein, bound to a cytotoxic agent, known as the payload. The use of ADCs is already common practice in several cancers, thanks to their efficacy and potentially more manageable toxicity profile, resulting from the release of the cytostatic payload directly in the tumors. Currently, early-phase trials of ADCs in non–small cell lung cancer are rapidly gaining ground, with promising results targeting HER2 (human epidermal growth factor 2), HER3, TROP2 (trophoblast cell surface antigen 2), MET, CEACAM5 (carcinoembryonic antigen–related cell adhesion molecule 5), and PTK7 (tyrosine protein kinase–like 7). Unfortunately, in small cell lung cancer, trials targeting the ubiquitous DLL3 (delta-like ligand 3) protein have failed to show clinically relevant results, despite significant toxicity.
A Systematic Review to Evaluate a Possible Association Between Congenital Toxoplasmosis and Preterm Labor

Background: Congenital toxoplasmosis (CT) is a widespread infection in several countries, and it is defined as an infection of a fetus, newborn, or infant under 1 year of age. Moreover, it represents a thread to pregnant women globally. The objective of our study is to evaluate a potential association between prematurity and CT and whether intrauterine transmission impacts gestational length during pregnancy. Methods: PubMed, Cochrane Library and Google Scholar databases were searched from 1950 to 2019. Case–control studies, retrospective, and prospective cohort studies were eligible. Seven studies were included from a total of 314. The Newcastle–Ottawa scale was used to establish the quality of the articles included. Results: Based on our review, an association between CT and preterm labor was not established, which may reflect heterogeneity in screening, treatments administered, and differing reported incidences of CT across continents over 69 years. A multicenter prospective cohort study powered to investigate a potential association is indicated. Conclusion: Further studies are needed including multicenter prospective cohort studies powered to investigate key clinical associations such as vertical transmission and preterm birth.
SPITZER-IRAC IDENTIFICATION OF HERSCHEL-ATLAS SPIRE SOURCES

We use Spitzer-IRAC data to identify near-infrared counterparts to submillimeter galaxies detected with Herschel-SPIRE at 250 μm in the Herschel Astrophysical Terahertz Large Area Survey. Using a likelihood ratio analysis we identify 146 reliable IRAC counterparts to 123 SPIRE sources out of the 159 in the survey area. We find that, compared to the field population, the SPIRE counterparts occupy a distinct region of the 3.6 and 4.5 μm color–magnitude space, and we use this property to identify 23 further counterparts to 13 SPIRE sources. The IRAC identification rate of 86% is significantly higher than those that have been demonstrated with wide-field ground-based optical and near-IR imaging of Herschel fields. We estimate a false identification rate of 3.6%, corresponding to 4–5 sources. Among the 73 counterparts that are undetected in Sloan Digital Sky Survey, 57 have both 3.6 and 4.5 μm coverage. Of these, 43 have [3.6] − [4.5] > 0, indicating that they are likely to be at z ≳ 1.4. Thus, ∼40% of identified SPIRE galaxies are likely to be high-redshift (z ≳ 1.4) sources. We discuss the statistical properties of the IRAC-identified SPIRE galaxy sample including far-IR luminosities, dust temperatures, star formation rates, and stellar masses. The majority of our detected galaxies have 1010–1011 L☉ total IR luminosities and are not intense starbursting galaxies as those found at z ∼ 2, but they have a factor of 2–3 above average specific star formation rates compared to near-IR selected galaxy samples.
CHARACTERIZING THE AB DORADUS MOVING GROUP VIA HIGH-RESOLUTION SPECTROSCOPY AND KINEMATIC TRACEBACK

We present a detailed analysis of 10 proposed F and G members of the nearby, young moving group AB Doradus (ABD). Our sample was obtained using the 2.7 m telescope at the McDonald Observatory with the coude echelle spectrograph, achieving R ∼ 60,000 and signal-to-noise ratio ∼200. We derive spectroscopic Teff, log(g), [Fe/H], and microturbulance (vt) using a bootstrap method of the TGVIT software resulting in typical errors of 33K in Teff, 0.08 dex in log(g), 0.03 dex in [Fe/H], and 0.13 km s−1 in vt. Characterization of the ABD sample is performed in three ways: (1) chemical homogeneity, (2) kinematic traceback, and (3) isochrone fitting. We find the average metal abundance is [M/H] = −0.03 ± 0.06 with a traceback age of 125 Myr. Our stars were fit to three different evolutionary models and we found that the best match to our ABD sample is the YREC [M/H] = −0.1 model. In our sample of 10 stars, we identify 1 star that is a probable non-member, 3 enigmatic stars, and 6 stars with confirmed membership. We also present a list of chemically coherent stars from this study and the Barenfeld et al. study.
Life satisfaction and depression among women living in slum areas of Bhubaneswar

Introduction: Generally, slum areas are overcrowded and have poor quality of house and poor access to safe water, sanitization and other infrastructure. The lack of basic necessities and insecurity to earn for livelihood may cause depression among slum dwellers. But, since everybody has their own perception regarding success and satisfaction, it is worthwhile to know the prevalence of depression and life satisfaction among the slum dwellers. Aim: To find out the prevalence of life satisfaction and depression and its associated factors of life satisfaction and depression among reproductive age group women of slum area. Materials and Methods: A cross-sectional study was carried out among 386 slum women of reproductive age during January 2019 to September 2020 in Bhubaneswar. Tools used women (p=0.045). The association of socioeconomic status with depression is found to be statistically significant in the present study (p=0.027). Conclusion: The life satisfaction among slum women is 37.5% and prevalence of depression is 7.2%. Life satisfaction was similar regardless of marital status, social class and age. However, depression was more in younger women and women belonging to lower class in comparison to middle class.
WHY BARYONS MATTER: THE KINEMATICS OF DWARF SPHEROIDAL SATELLITES

We use high-resolution cosmological simulations of Milky Way (MW) mass galaxies that include both baryons and dark matter (DM) to show that baryonic physics (energetic feedback from supernovae and subsequent tidal stripping) significantly reduces the DM mass in the central regions of luminous satellite galaxies. The reduced central masses of the simulated satellites reproduce the observed internal dynamics of MW and M31 satellites as a function of luminosity. We use these realistic satellites to update predictions for the observed velocity and luminosity functions of satellites around MW-mass galaxies when baryonic effects are accounted for. We also predict that field dwarf galaxies in the same luminosity range as the MW classical satellites should not exhibit velocities as low as the satellites because the field dwarfs do not experience tidal stripping. Additionally, the early formation times of the satellites compared to field galaxies at the same luminosity may be apparent in the star formation histories of the two populations. Including baryonic physics in cold dark matter (CDM) models naturally explains the observed low DM densities in the MWs dwarf spheroidal population. Our simulations therefore resolve the tension between kinematics predicted in CDM theory and observations of satellites, without invoking alternative forms of DM.
STAR CLUSTERS IN M31. II. OLD CLUSTER METALLICITIES AND AGES FROM HECTOSPEC DATA

We present new high signal-to-noise spectroscopic data on the M31 globular cluster (GC) system, obtained with the Hectospec multifiber spectrograph on the 6.5 m MMT. More than 300 clusters have been observed at a resolution of 5 Å and with a median S/N of 75 per Å, providing velocities with a median uncertainty of 6 km s−1. The primary focus of this paper is the determination of mean cluster metallicities, ages, and reddenings. Metallicities were estimated using a calibration of Lick indices with [Fe/H] provided by Galactic GCs. These match well the metallicities of 24 M31 clusters determined from Hubble Space Telescope color–magnitude diagrams, the differences having an rms of 0.2 dex. The metallicity distribution is not generally bimodal, in strong distinction with the bimodal Galactic globular distribution. Rather, the M31 distribution shows a broad peak, centered at [Fe/H] = −1, possibly with minor peaks at [Fe/H] = −1.4, −0.7, and −0.2, suggesting that the cluster systems of M31 and the Milky Way had different formation histories. Ages for clusters with [Fe/H] > − 1 were determined using the automatic stellar population analysis program EZ_Ages. We find no evidence for massive clusters in M31 with intermediate ages, those between 2 and 6 Gyr. Moreover, we find that the mean ages of the old GCs are remarkably constant over about a decade in metallicity (−0.95≲ [Fe/H] ≲0.0).
The Goldman-Turaev Lie bialgebra and the Kashiwara-Vergne problem in higher genera.

For a compact oriented surface $\Sigma$ of genus $g$ with $n+1$ boundary components, the space $\mathfrak{g}$ spanned by free homotopy classes of loops in $\Sigma$ carries the structure of a Lie bialgebra. The Lie bracket was defined by Goldman and it is canonical. The Lie cobracket was defined by Turaev and it depends on the framing of $\Sigma$. The Lie bialgebra $\mathfrak{g}$ has a natural decreasing filtration such that both the Goldman bracket and the Turaev cobracket have degree $(-2)$. In this paper, we address the following Goldman-Turaev formality problem: construct a Lie bialgebra homomorphism $\theta$ from $\mathfrak{g}$ to its associated graded $gr\, \mathfrak{g}$ such that $gr\, \theta = {\rm id}$. In order to solve it, we define a family of higher genus Kashiwara-Vergne (KV) problems for an element $F\in Aut(L)$, where $L$ is a free Lie algebra. In the case of $g=0$ and $n=2$, the problem for $F$ is the classical KV problem from Lie theory. For $g>0$, these KV problems are new. Our main results are as follows. On the one hand, every solution of the KV problem induces a GT formality map. On the other hand, higher genus KV problems admit solutions for any $g$ and $n$. In fact, the solution reduces to two important cases: $g=0, n=2$ which admits solutions by Alekseev and Torossian and $g=1, n=1$ for which we construct solutions in terms of certain elliptic associators following Enriquez. By combining these two results, we obtain a proof of the GT formality for any $g$ and $n$. We also study the set of solutions of higher genus KV problems and introduce pro-unipotent groups $KRV^{(g,n+1)}$ which act on them freely and transitively. These groups admit graded pro-nilpotent Lie algebras $krv^{(g, n+1)}$. We show that the elliptic Lie algebra $krv^{(1,1)}$ contains a copy of the Grothendieck-Teichmuller Lie algebra $grt_1$ as well as symplectic derivations $\delta_{2n}$.
“STARLESS” SUPER-JEANS CORES IN FOUR GOULD BELT CLOUDS

From a survey of 729 cores based on JCMT/SCUBA data, we present an analysis of 17 candidate starless cores with masses that exceed their stable Jeans masses. We re-examine the classification of these super-Jeans cores using Spitzer maps and find that 3 are re-classified as protostellar, 11 have ambiguous emission near the core positions, and 3 appear to be genuinely starless. We suggest that the 3 starless and 11 undetermined super-Jeans cores represent excellent targets for future observational and computational study to understand the evolution of dense cores and the process of star formation.
A Systematic Review and Meta-Analysis of Depression Prevalence Among Nigerian Students Pursuing Higher Education

Mean age of students across the 18 studies ranged from 19.09 to 26.3 years, with sample sizes ranging from 81 to 1482 participants. The pooled depression prevalence across studies was 26% (95% CI 0.18, 0.36) with high heterogeneity (I2=97%, τ2=0.9512). The subgroup analyses showed that higher education students in the Northwestern region of Nigeria have the highest depression prevalence (45.9%), followed by the South-South region (33%), Southeastern (22.1%), and Southwestern region (18.1%). Our findings show that depression among higher ABSTRACT Depression is one of the most prevalent mental health disorders currently going undiagnosed in many developing countries, including Nigeria. Stigmatization, inadequate financial resources, poor healthcare infrastructure for accurate diagnosis, and low research attention are contributing factors to the prevalence of depression among youths in West Africa. This study therefore estimated the prevalence of depression among higher education students in Nigeria. Data was extracted and examined from 1225 publications by three independent reviewers. Pooling of logit-transformed data was done using generalized linear mixed-effects model, while restricted maximum likelihood was used to estimate between-study variance (τ2). Knapp-Hartung adjustments were included for calculating the confidence intervals around pooled effects; and R was used to calculate pooled estimates of
Recovering cores and cusps in dark matter haloes using mock velocity field observations

We present mock DensePak Integral Field Unit (IFU) velocity fields, rotation curves, and halo fits for disc galaxies formed in spherical and triaxial cuspy dark matter haloes, and spherical cored dark matter haloes. The simulated galaxies are “observed” under a variety of realistic conditions to determine how well the underlying dark matter halo can be recovered and to test the hypothesis that cuspy haloes can be mistaken for cored haloes. We find that the appearance of the velocity field is distinctly different depending on the underlying halo type. We also find that we can successfully recover the parameters of the underlying dark matter halo. Cuspy haloes appear cuspy in the data and cored haloes appear cored. Our results suggest that the cores observed using high-resolution velocity fields in real dark matter-dominated galaxies are genuine and cannot be ascribed to systematic errors, halo triaxiality, or non-circular motions.
INFERRING THE ECCENTRICITY DISTRIBUTION

Standard maximum-likelihood estimators for binary-star and exoplanet eccentricities are biased high, in the sense that the estimated eccentricity tends to be larger than the true eccentricity. As with most non-trivial observables, a simple histogram of estimated eccentricities is not a good estimate of the true eccentricity distribution. Here, we develop and test a hierarchical probabilistic method for performing the relevant meta-analysis, that is, inferring the true eccentricity distribution, taking as input the likelihood functions for the individual star eccentricities, or samplings of the posterior probability distributions for the eccentricities (under a given, uninformative prior). The method is a simple implementation of a hierarchical Bayesian model; it can also be seen as a kind of heteroscedastic deconvolution. It can be applied to any quantity measured with finite precision—other orbital parameters, or indeed any astronomical measurements of any kind, including magnitudes, distances, or photometric redshifts—so long as the measurements have been communicated as a likelihood function or a posterior sampling.
A Szemer\'edi-Trotter type theorem, sum-product estimates in finite quasifields, and related results

We prove a Szemer\'edi-Trotter type theorem and a sum-product estimate in the setting of finite quasifields. These estimates generalize results of the fourth author, of Garaev, and of Vu. We generalize results of Gyarmati and S\'ark\"ozy on the solvability of the equations $a + b = cd$ and $ab + 1 = cd$ over a finite field. Other analogous results that are known to hold in finite fields are generalized to finite quasifields.
Resonant X-Ray Scattering Studies of Charge Order in Cuprates

X-ray techniques have been used for more than a century to study the atomic and electronic structure in practically any type of material. The advent of correlated electron systems, in particular complex oxides, brought about new scientific challenges and opportunities for the advancement of conventional X-ray methods. In this context, the need for new approaches capable of selectively sensing new forms of orders involving all degrees of freedom—charge, orbital, spin, and lattice—paved the way for the emergence and success of resonant X-ray scattering, which has become an increasingly popular and powerful tool for the study of electronic ordering phenomena in solids. We review the recent resonant X-ray scattering breakthroughs in the copper oxide high-temperature superconductors, in particular regarding the phenomenon of charge order, a broken-symmetry state occurring when valence electrons self-organize into periodic structures. After a brief historical perspective on charge order, we outline the mileston.
Inverse problems of determining sources of the fractional partial differential equations

In this chapter, we mainly review theoretical results on inverse source problems for diffusion equations with the Caputo time-fractional derivatives of order α ∈ (0, 1). Our survey covers the following types of inverse problems: • determination of time-dependent functions in interior source terms • determination of space-dependent functions in interior source terms • determination of time-dependent functions appearing in boundary conditions
Design of a photonic lattice using shortcuts to adiabaticity

In this article we use the method of shortcuts to adiabaticity to design a photonic lattice (array of waveguides) which can drive the input light to a controlled location at the output. The output position in the array is determined by functions of the propagation distance along the waveguides, which modulate the lattice characteristics (index of refraction, first and second neighbor couplings). The proposed coupler is expected to posses the robustness properties of the design method, coming from its adiabatic nature, and also to have a smaller footprint than purely adiabatic couplers. The present work provides a very interesting example where methods from quantum control can be exploited to design lattices with desired input-output properties.