Miracle-dz/UniFAR-FTUs huggingface dataset:
Perception of sunflecks by the UV-B photoreceptor UV RESISTANCE LOCUS 8 1 17

List of R.U. and J.J.C. devised this project and designed the experiments. V.M. performed the experiments, obtained the samples, measured growth and gene expression and analysed the data. M.B. performed the protein blots. C.C. conducted the confocal microscopy. R. S. supervised and with field and laboratory experiments at IFEVA. J.J.C. the ABSTRACT 45 Sunflecks, transient patches of light that penetrate through gaps in the canopy and transiently 46 interrupt shade, are eco-physiologically and agriculturally important sources of energy for carbon 47 gain, but our molecular understanding of how plant organs perceive and respond to sunflecks 48 remains limited. The UV-B photoreceptor UV RESISTANCE LOCUS 8 (UVR8) is a recent addition to 49 the list of plant photo-sensory receptors and, we have made considerable advances in our 50 understanding of the physiology and molecular mechanisms of action of UVR8 and its signalling 51 pathway. However, the function of UVR8 in the natural environment is poorly understood. Here 52 we show that the UVR8 dimer / monomer ratio responds quantitatively and reversibly to the 53 intensity of sunflecks that interrupt shade in the field. Sunflecks reduced hypocotyl growth and 54 increased CHALCONE SYNTHASE ( CHS ) and ELONGATED HYPOCOTYL 5 ( HY5 ) gene expression and 55 CHS protein abundance in wild-type Arabidopsis ( Arabidopsis thaliana ) seedlings, but the uvr8 56 mutant was impaired in these responses. UVR8 was also required for normal nuclear dynamics of 57 CONSTITUTIVELY PHOTOMORPHOGENIC 1 (COP1). We propose that UVR8 plays an important role 58 in the plant perception of and response to sunflecks. 59
A View of Platelets in Dengue A View of Platelets in Dengue

Platelets were mainly associated with coagulation and hemostasis; however, other biolog- ical effects have been attributed to platelets, including angiogenesis, extracellular matrix synthesis, inflammation, and immune response. Dengue virus infection causes 200 mil - lion cases of severe flu-like illness annually, escalating to life-threatening hemorrhagic fever or shock syndrome. Some hypotheses are postulated for immunopathogenesis of dengue, including antibody enhancement theory, T-cell activation of cross-reactive mem -ory, and original antigenic sin. All hypotheses, to some extent, induce an overproduction or a skewed profile of cytokine release, giving rise to the term cytokine storm/cytokine tsunami. Although thrombocytopenia is typical of both mild and severe diseases, the mechanism triggering platelet reduction is incompletely understood. In dengue, plate lets are one of the major cell populations affected by direct and/or indirect mechanisms of infection. It is common to observe both thrombocytopenia and platelet dysfunction in dengue, both strongly related to the clinical outcome. Thus, platelets are frequently affected in dengue, either for alteration of their own functionality, for “silent transport” of virus, or as an anti-viral immune cell. In this way, we describe some of functional aspects of platelets on dengue,
T HE GEOMETRY OF FLIP GRAPHS AND MAPPING CLASS GROUPS

The space of topological decompositions into triangulations of a surface has a natural graph structure where two triangulations share an edge if they are related by a so-called ﬂip. This space is a sort of combinatorial Teichm¨uller space and is quasi-isometric to the underlying mapping class group. We study this space in two main directions. We ﬁrst show that strata corresponding to triangulations containing a same multiarc are strongly convex within the whole space and use this result to deduce properties about the mapping class group. We then focus on the quotient of this space by the mapping class group to obtain a type of combinatorial moduli space. In particular, we are able to identity how the diameters of the resulting spaces grow in terms of the complexity of the underlying surfaces. 05C25, 30F60, 32G15, 57M50. 05C12, 05C60, 30F10, 57M07, 57M60.
A STUDY ON DIFFERENT PREDICTORS FOR ACUTE ASTHMA ATTACK IN ASTHMATIC PATIENTS

: Introduction: Asthma is a serious global health problem. The prevalence of asthma is increasing in most countries, especially among children. The burden of asthma is experienced not only in terms of healthcare costs but also as lost productivity. Objectives of the study: The main objective of the study is to analyze different predictors for acute asthma attack in asthmatic patients. Material and methods: This retrospective study was conducted at hospitals of Mandi Bahauddin during Jan 2018 to May 2018. In this study we studied one hundred patients who were referred with exacerbation of asthma or other acute asthmatic symptoms and went under treatment in hospitals. Pulse Oximetry was done and documented at arrival and 30, 60, 120 minutes after arrival. PImax and PEmax were measured and documented at arrival and 60, 120 minutes after arrival. Results: Detailed frequencies of exposures in patients both with and without hospital admissions due to asthma exacerbations in the year following admission to the study are shown in Table 1. The majority of these associations are self-explanatory; however, some deserve special attention. Ratio of FEV1/FVC, PEF, PImax, PEmax and FVC with cut-off point 50.4, 2.05, 62.5, 63.5 and 2.7 with 70% sensitivity were capable to forecast the need for hospitalization. Conclusion: It is concluded that FEV1 and PEF that have role in admission criteria, FEV1/FVC at arrival to ED and
Analyticaland PhysiologicalCharacteristicsof Prostate-SpecificAntigenand ProstaticAcid Phosphatasein Serum Compared

We did a comparative anaiysis of the physiological and analytical properties of prostate-specific antigen (PSA), acid phosphatase (ACP; EC 3.1.32) activity, and acid phosphatase antigen (PAP) in serum. The PSA assay is sensitive to 0.2 p.9/L and demonstrates good linearity (y = 1.01x + 0.74). The CV was 3.9% at 40 j.g/L, 8.0% at 3.1 pgIL. PSA and PAP are less stable at 4 #{176}Cthan at -20 #{176}C.Serum PAP and ACP concentrations showed large intra-individual fluctuations (average CVs of 22% and 24%, respectively), which were not observed with PSA measurements (average CV 6.2%). We saw significant correlation with the magnitude of physiological change when analytes were compared for serially collected split samples [yPSA) = 0.14x(PAP) + 0.00, r = 0.767), which indicates that a common factor is influencing this variation. The excellent analytical perform-ance, tissue specificity, and small degree of intra-individual variance are characteristics that favor the measurement of PSA in serum for monitoring patients with prostatic cancer.
Reserve Requirements as a Tool of Monetary Policy Empirical Study of the Money Multiplier Theory

The use of statutory reserve requirement as a monetary policy tool has arguably diminished in recent years. Moreover, the money multiplier, a fundamental macroeconomic theory, which deals with the relationship between the monetary base, required reserves and the money supply, has been a target for some heavy critique. The money multiplier theory encompasses a required reserve ratio, excess reserve ratio and currency ratio to explain the changes in the money multiplier. The multiplier, which in itself is the ratio of the broad money and the monetary base, is described as decreasing function of the ratios. In this paper we calculate the respective ratios and employ a linear regression model based on the multiplier theory to examine the relationships between the ratios. The effects are estimated individually in USA, Eurozone, Japan and in a panel data analysis combining all three currency areas. We find that the reserve requirement ratios do not significantly explain the changes in the money multiplier in the USA or in the Eurozone. However, the reserve requirement ratios are found to have a significant effect in Japan and in the pooled data analysis. Further, in all of the cases, except in the Eurozone, the empirical model of the multiplier is found to explain significantly the variation in the multiplier, albeit with poor explanatory power in the pooled model. The varying explanatory power of the model and the altering significance of the reserve requirements suggests that the multiplier theory does not hold exactly. This implies that the effectiveness of the reserve requirements as a tool of monetary policy should not be taken as granted in contemporary economies.
Cardiovascular Neurohormonal Regulation BDNF downregulates (cid:2) -adrenergic receptor-mediated hypotensive mechanisms in the paraventricular nucleus of the hypothalamus

B. BDNF Downregulates (cid:2) -adrenergic receptor-mediated hypotensive mechanisms in the paraventricular nucleus of the hypothalamus. Am J Physiol Heart Circ Physiol 317: H1258–H1271, 2019. 2019; neurotrophic factor (BDNF) is upregulated in the paraventricular nucleus of the hypothalamus (PVN) in response to hypertensive stimuli such as stress and hyperosmolality, and BDNF acting in the PVN plays a key role in elevating sympathetic activity and blood pressure. However, downstream mechanisms mediating these effects remain unclear. We tested the hypothesis that BDNF increases blood pressure, in part by diminishing inhibitory hypotensive input from nucleus of the solitary tract (NTS) catecholaminergic neurons projecting to the PVN. Male Sprague-Dawley rats received bilateral PVN injections of viral vectors expressing either green ﬂuorescent protein (GFP) or BDNF and bilateral NTS injections of vehicle or anti-dopamine- (cid:2) -hydroxylase-conjugated saporin (DSAP), a neurotoxin that selectively lesions noradrenergic and adrenergic neurons. BDNF overexpression in the PVN without NTS lesioning signiﬁcantly increased mean arterial pressure (MAP) in awake animals by 18.7 (cid:3) 1.8 mmHg. DSAP treatment also increased MAP in the GFP group, by 9.8 (cid:3) 3.2 mmHg, but failed to affect MAP in the BDNF group, indicating a BDNF-induced loss of NTS catecholaminergic hypotensive effects. In addition, in (cid:4) -chloralose-urethane-anesthetized rats, hypotensive responses to PVN injections of the (cid:2) -adrenergic agonist isoprenaline were signiﬁcantly attenuated by BDNF overexpression, whereas PVN injections of phenylephrine had no effect on blood pressure. BDNF treatment was also found to signiﬁcantly reduce (cid:2) 1 -adrenergic receptor mRNA expression in the PVN, whereas expression of other adrenergic receptors was unaffected. In summary, increased BDNF expression in the PVN elevates blood pressure, in part by downregulating (cid:2) -receptor signaling and diminishing hypotensive catecholaminergic input from the NTS to the PVN. NEW & NOTEWORTHY We have shown that BDNF, a key hypothalamic regulator of blood pressure, disrupts catecholaminergic signaling between the NTS and the PVN by reducing the responsiveness of PVN neurons to inhibitory hypotensive (cid:2) -adrenergic input from the NTS. This may be occurring partly via BDNF-mediated downregulation of (cid:2) 1 -adrenergic receptor expression in the PVN and results in an increase in blood pressure.
University of Birmingham Metamagnetic Quantum Criticality in Sr3Ru2O7

We consider the metamagnetic transition in the bilayer ruthenate, Sr 3 Ru 2 O 7 , and use this to motivate a renormalization group treatment of a zero-temperature quantum-critical end-point. We summarize the results of mean (cid:12)eld theory and give a pedagogical derivation of the renormalization-group equations. These are then solved to yield numerical results for the susceptibility, the speci(cid:12)c heat and the resistivity exponent which can be compared with measured data on Sr 3 Ru 2 O 7 to provide a powerful test for the standard framework of metallic quantum criticality. The observed approach to the critical point is well-described by our theory explaining a number of unusual features of experimental data. The puzzling behaviour very near to the critical point itself, though, is not accounted for by this, or any other theory with a Fermi surface.
Thromboprophylaxis in octogenarians with atrial fibrillation

Background: atrial fibrillation (AF) is the commonest chronic arrhythmia with a prevalence of 9% in octogenarians and accounts for 24% of the stroke risk in this population. Although trials demonstrate reductions in stroke with warfarin, audit data show that it is still underused. However, anti-coagulation in the very elderly is not without risk. Methods: randomised open labelled prospective study of primary thromboprophylaxis for AF. Patients aged >80 and <90 were randomised to receive dose-adjusted warfarin (INR 2.0–3.0) or aspirin 300 mg. All patients had permanent AF, were ambulant, had Folstein mini mental score >25 and had no contraindications to either treatment. Follow-up was for 1 year with 3 monthly visits. The primary outcome measure was a comparative frequency of combined endpoints comprising death, thromboembolism, serious bleeding and withdrawal from the study. Results: seventy-five patients (aspirin 39; warfarin 36) were entered (mean age 83.9, 47% male). There were significantly more adverse events with aspirin (13/39; 33%) than warfarin (2/36; 6%), P = 0.002. 10/13 aspirin adverse events were caused by side effects and serious bleeding; there were three deaths (two aspirin, one warfarin). Conclusion: dose-adjusted warfarin was significantly better tolerated with fewer adverse events than aspirin 300 mg in this elderly population. Although aspirin 75 mg may have been better tolerated, there is no evidence for efficacy in AF at this dose.
Occurrence of spvA Virulence Gene and Clinical Signiﬁcance for Multidrug-Resistant Salmonella Strains (cid:1)

Nontyphoidal Salmonella strains are important reservoirs of antimicrobial resistance. An important issue that has not been investigated is whether the multiresistant Salmonella strains are more virulent than their susceptible counterparts. Salmonella isolates collected from clinical human ( n (cid:1) 888) and porcine ( n (cid:1) 2,120) cases at the same time period and geographic location were investigated. Antimicrobial susceptibility, PCR analysis for the spvA virulence gene, and pulsed-ﬁeld gel electrophoresis (PFGE) genotyping were done. Carriage of spvA was associated with multidrug-resistant (MDR) type ACSSuT strains (odds ratio, 7.1; P < 0.05), a type often implicated in bacteremic human cases. PFGE revealed that clinical isolates from pigs were more clonally related to those of human origin than the nonclinical porcine isolates. The ﬁndings suggest that MDR strains that also carry speciﬁc virulence factors are more likely
Earnings Management in Unlisted Firms: Cross-country and Time Difference Analyses Across four Emerging Eastern European Countries Between 2003-2009

– We investigate earnings management in unlisted firms across four emerging Eastern European countries: Poland, Hungary, Slovakia and the Czech Republic between 2003-2009. We are interested in determining whether earnings management is being practiced in emerging countries. The question arises as these countries increasingly have more importance in the European market, and till now have been barely explored. Specifically, we investigate whether companies from these emerging countries manage their earnings and whether they do it to increase or decrease the earnings figure. We also analyze whether the manipulation varies in time affected by different events, and cross-sectional analysis between the countries in the sample. Based on discretionary accruals during the period from 2003 to 2009, the results show that an average firm from emerging Eastern European countries manages earnings downwards. Results suggest that the manipulation varies over the years: a decrease in earnings management between 2003 and 2007, and increase in earnings manipulation between 2008 and 2009. We also confirm that there is a significant difference in earnings management between the emerging countries analyzed. Examining earnings management behaviour in new emerging economies may help to understand how managers cope with the pressure in highly competitive European markets. It opens new discussions and debates on the comparison of both European markets, and on the possible investigations of reasons of such manipulation.
Effect of Kegel exercise on improving manifestations of uterine prolapse and its degree among pre-menopausal women

Background: Uterine prolapse is the main public health problem of reproductive age women in Egypt. Uterine prolapse (UP), which affects about 10% of women at reproductive age in developing countries, is the most frequently reported cause of poor health in women of reproductive age and premenopausal women (Silwal et al ., 2016). Aim of the study: To evaluate the effect of Kegel exercise on improving manifestations of uterine prolapse and its degree among pre-menopausal women. Research design: Quasi-experimental research design was used. Setting: The study was conducted at gynecological outpatient clinics at Minia University Hospital for Obstetric & Pediatric and El - Minia General Hospital. Subjects: A Purposive sample composed of 102 pre-menopausal women was recruited for the current study and divided equally by using simple random sample. following: Modified Oxford Grading System, 5- Follow up evaluation sheet (dairy record). Results: The current study reveals; that there were statistical significant relation between women compliance of Kegel exercise and uterine prolapse degrees at (P value ≤ 0.029). In addition, there was high statistical significant relation between women compliance of Kegel exercise, uterine prolapse symptoms and muscle strength at (P value ≤ 0.000 and ≤ 0.007). Conclusion & Recommendations: The findings showed that 3months pelvic muscle exercises improve the manifestations of uterine prolapse and its degree among pre-menopausal women. Applying an educational program about performance of Kegel exercises was recommended.
E ﬀ ect of Supplementary Light Intensity on Quality of Grafted Tomato Seedlings and Expression of Two Photosynthetic Genes and Proteins

: Lower quality and longer production periods of grafted seedlings, especially grafted plug seedlings of fruit vegetables, may result from insu ﬃ cient amounts of light, particularly in rainy seasons and winter. Supplemental artiﬁcial lighting may be a feasible solution to such problems. This study was conducted to evaluate light intensity’s inﬂuence on the quality of grafted tomato seedlings, ‘Super Sunload’ and ‘Super Dotaerang’ were grafted onto the ‘B-Blocking’ rootstock. To improve their quality, grafted seedlings were moved to a glasshouse and grown for 10 days. The glasshouse had a combination of natural lighting from the sun and supplemental lighting from LEDs (W 1 R 2 B 2 ) for 16 h / day. Light intensity of natural lighting was 490 µ mol · m − 2 · s − 1 photosynthetic photon ﬂux density (PPFD) and that of supplemental lighting was 50, 100, or 150 µ mol · m − 2 · s − 1 PPFD. The culture environment had 30 / 25 ◦ C day / night temperatures, 70% ± 5% relative humidity (RH), and a natural photoperiod of 14 h as well. Compared with quality of seedlings in supplemental lighting of 50 µ mol · m − 2 · s − 1 PPFD, that of seedlings in supplement lighting of 100 or 150 µ mol · m − 2 · s − 1 PPFD improved signiﬁcantly. With increasing light intensity, diameter, fresh weight, and dry weight, which were used to measure shoot growth, greatly improved. Leaf area, leaf thickness, and root biomass were also greater. However, for quality of seedlings, no signiﬁcant di ﬀ erences were discovered between supplement lighting of 100 µ mol · m − 2 · s − 1 PPFD and supplement lighting of 150 µ mol · m − 2 · s − 1 PPFD. Expressions of PsaA and PsbA (two photosynthetic genes) as well as the corresponding proteins increased signiﬁcantly in supplement lightning of 100 and 150 µ mol · m − 2 · s − 1 PPFD, especially in 100 µ mol · m − 2 · s − 1 PPFD. Overall, considering quality and expressions of two photosynthetic genes and proteins, supplemental light of 100 µ mol · m − 2 · s − 1 PPFD (W 1 R 2 B 1 ) would be the best choice to cultivate grafted tomato seedlings. morphologies of ‘SS’ and ‘SD’ after treating for 10 d by using supplementary lighting with a di ﬀ erent light intensity. It showed that tomato seedlings grown in supplementary lighting of 100 and 150 had more biomass and were sturdier.
DDDT_A_254218 2535..2547

Qiongyao Zeng Yuncheng Che Yu Zhang Mei Chen Qiang Guo Wenjing Zhang 2,4 1Faculty of Life Science and Biotechnology, Kunming University of Science and Technology, Kunming 650500, People’s Republic of China; 2Medical School, Kunming University of Science and Technology, Kunming 650500, People’s Republic of China; 3Department of Gastroenterology, The First People’s Hospital of Yunnan Province, Yunnan Provincial Institute of Digestive Medicine, Kunming 650032, People’s Republic of China; 4Department of Medical Oncology, The First People’s Hospital of Yunnan Province, Kunming 650032, People’s Republic of China Purpose: Colorectal cancer (CRC) is one of the most commonly occurring cancers and is associated with high morbidity and mortality. Nevertheless, there is currently no safe and effective treatment for this condition. Thymol is a phenolic compound that is recognized as safe for use in food as well as medical and cosmetic fields. Increasing evidence has indicated that thymol exerts prominent antitumor effects in a variety of cancers, including CRC. However, how thymol elicits these effects on CRC and the associated underlying mechanisms remains unclear. Methods: HCT116 and Lovo cells were treated with different concentrations of thymol. Cell Counting Kit-8 (CCK-8) and transwell migration and invasion assays were used to evaluate cell proliferation, migration, and invasion, respectively. Cell apoptosis and cell cycle distribution were measured by flow cytometry. RT-qPCR, Western blot, and immunohistochemistry were used to detect the expression of related genes and their protein products. Results: In this study, we tested the antitumor activity of thymol extracted from a Chinese medicinal herb, Thymus vulgaris L. We show that thymol treatment in vitro inhibited cell proliferation and induced apoptosis and cell cycle arrest in CRC. Furthermore, in vivo treatment with 75 and 150 mg/kg thymol led to a significant decrease in tumor volume. Thymol administration induced CRC cell apoptosis through activation of the BAX/Bcl-2 signaling pathway. In addition, thymol suppressed CRC cell epithelial–mesenchymal transition (EMT), invasion, and metastasis via inhibiting the activation of the Wnt/β-catenin pathway, both in vitro and in vivo. Conclusion: Thymol may prevent CRC progression through inhibition of the Wnt/β-catenin signaling pathway, highlighting its potential as a novel therapeutic option for the treatment of CRC.