Miracle-dz/UniFAR-FTUs huggingface dataset:
Developmental Programming of Fertility in Cattle—Is It a Cause for Concern?

Simple Summary Poor fertility is the main reason for premature culling of cattle. Dam factors and external variables can both influence how the calf fetus develops, known as fetal programming. Dam factors include age, parity, body condition, health and milk yield. External variables include nutrition and the environment during pregnancy. These all affect placental growth and the nutrient supply to the fetus, which in turn influence the size, shape and body composition of the calf. Postnatal growth rates, organ structure and immunity can all be affected. The impact on organs such as ovaries, liver, pancreas, lungs, spleen and thymus is dependent on the stage of pregnancy during which the fetal environment is sub-optimal. Regulatory systems which influence growth, metabolism and fertility can be permanently reprogrammed. Most changes affecting fertility are probably indirect. For example, calf health, the timing of puberty, age and size at first calving, and the ability to adapt to lactation after calving can all alter future reproductive potential. The size of these effects is hard to quantify due to practical difficulties in obtaining data over a sufficient time period. Nevertheless, there is compelling evidence that the fertility of some cows is compromised by events happening before their birth. Abstract Cattle fertility remains sub-optimal despite recent improvements in genetic selection. The extent to which an individual heifer fulfils her genetic potential can be influenced by fetal programming during pregnancy. This paper reviews the evidence that a dam’s age, milk yield, health, nutrition and environment during pregnancy may programme permanent structural and physiological modifications in the fetus. These can alter the morphology and body composition of the calf, postnatal growth rates, organ structure, metabolic function, endocrine function and immunity. Potentially important organs which can be affected include the ovaries, liver, pancreas, lungs, spleen and thymus. Insulin/glucose homeostasis, the somatotropic axis and the hypothalamo-pituitary-adrenal axis can all be permanently reprogrammed by the pre-natal environment. These changes may act directly at the level of the ovary to influence fertility, but most actions are indirect. For example, calf health, the timing of puberty, the age and body structure at first calving, and the ability to balance milk production with metabolic health and fertility after calving can all have an impact on reproductive potential. Definitive experiments to quantify the extent to which any of these effects do alter fertility are particularly challenging in cattle, as individual animals and their management are both very variable and lifetime fertility takes many years to assess. Nevertheless, the evidence is compelling that the fertility of some animals is compromised by events happening before they are born. Calf phenotype at birth and their conception data as a nulliparous heifer should therefore both be assessed to avoid such animals being used as herd replacements.
SPITZER MID-IR SPECTROSCOPY OF POWERFUL 2Jy AND 3CRR RADIO GALAXIES. II. AGN POWER INDICATORS AND UNIFICATION

It remains uncertain which continuum and emission line diagnostics best indicate the bolometric powers of active galactic nuclei (AGNs), especially given the attenuation caused by the circumnuclear material and the possible contamination by components related to star formation. Here we use mid-IR spectra along with multiwavelength data to investigate the merit of various diagnostics of AGN radiative power, including the mid-IR [Ne iii] λ25. 89 μm and [O iv] λ25. 89 μm fine-structure lines, the optical [O iii] λ5007 forbidden line, and mid-IR 24 μm, 5 GHz radio, and X-ray continuum emission, for complete samples of 46 2Jy radio galaxies (0.05 < z < 0.7) and 17 3CRR FRII radio galaxies (z < 0.1). We find that the mid-IR [O iv] line is the most reliable indicator of AGN power for powerful radio-loud AGNs. By assuming that the [O iv] is emitted isotropically, and comparing the [O iii] and 24 μm luminosities of the broad- and narrow-line AGNs in our samples at fixed [O iv] luminosity, we show that the [O iii] and 24 μm emission are both mildly attenuated in the narrow-line compared to the broad-line objects by a factor of ≈2. However, despite this attenuation, the [O iii] and 24 μm luminosities are better AGN power indicators for our sample than either the 5 GHz radio or the X-ray continuum luminosities. We also detect the mid-IR 9.7 μm silicate feature in the spectra of many objects but not ubiquitously: at least 40% of the sample shows no clear evidence for these features. We conclude that, for the majority of powerful radio galaxies, the mid-IR lines are powered by AGN photoionization.
Fast algorithms for the real discrete Fourier transform

Fast algorithms for the computation of the real discrete Fourier transform (RDFT) are discussed. Implementations based on the RDFT are always efficient, whereas the implementations based on the DFT are efficient only when signals to be processed are complex. The fast real Fourier transform (FRFT) algorithms discussed are the radix-2 decimation-in-time (DIT), the radix-4 DIT, the split-radix DIT, the split-radix DIF, the prime factor, and the Winograd FRFT algorithm. <<ETX>>
Optimization of Accelerated Solvent Extraction of Ginsenosides from Cultivated Wild Ginseng Using Response Surface Methodology

This study’s aim is to apply response surface methodology (RSM) to model and optimize the accelerated solvent extraction (ASE) technique for extracting the sum of ginsenosides (Rg1, Rb1, and Rg3) and total ginsenosides from cultivated wild ginseng. To extract ginsenosides from cultivated wild ginseng, a new ASE-based method, combined with RSM modeling and optimization, was developed. The RSM method, which was based on a five-level, three-factor central composite design, was used to obtain the optimal combination of extraction conditions. Briefly, the optimal extraction conditions for the sum of ginsenosides (Rg1, Rb1, and Rg3) and total ginsenoside were as follows: 88.64% ethanol for each extraction solvent, 105.98°C and 129.66°C of extraction temperature, 28.77 and 15.92 min of extraction time, extraction pressure of 1,500 psi, nitrogen purge of 60 s, flush volume of 60%, and one extraction cycle. A 3D response surface plot and contour plot derived from the mathematical models were applied to obtain the optimal conditions. Under the above conditions, the experimental extraction yields of the sum of ginsenosides (Rg1, Rb1, and Rg3) and total ginsenoside content were 7.45 and 32.82 mg/g, respectively, which closely agrees with the model’s prediction values.
A Spectral Line Survey in the 2 and 1.3 mm Windows toward the Carbon-rich Envelope of IRC +10216

We present the results of our spectral line surveys in the 1.3 and 2 mm windows toward the carbon-rich envelope of IRC +10216. There were 377 lines are detected in total, of which 360 lines are assigned to 57 known molecules (including 29 rare isotopomers and two cyclic isomers). Only 17 weak lines remain unidentified. Rotational lines of isotopomers 13CCH and HN13C are detected for the first time in IRC +10216 . The detection of the formaldehyde lines in this star is also confirmed. Possible abundance differences among the three 13C-substituted isotopic isomers of HC3N is reported. Isotopic ratios of C and O are confirmed to be nonsolar while those of S and Si to be nearly solar. Column densities have been estimated for 15 molecular species. Modified spectroscopic parameters have been calculated for NaCN, Na13CN, KCN, and SiC2. Transition frequencies from the present observations were used to improve the spectroscopic parameters of Si13CC,29SiC2, and 30SiC2.
A Rare Case Report of Sitagliptin-Induced Angioedema

Sitagliptin, a dipeptidyl peptidase-4 inhibitor, is used for the treatment of type 2 diabetes mellitus. Sitagliptin-induced angioedema has increased with the simultaneous use of angiotensin receptor blockers and angiotensin-converting enzyme inhibitors. We present a rare case of a 50-year-old female diagnosed with sitagliptin-induced angioedema. On examination, she had both upper and lower lip swelling without any respiratory compromise. On further investigation, her C1 esterase inhibitor level was normal. After stopping sitagliptin, her symptoms resolved. Thus, cautious use of dipeptidyl peptidase-4 inhibitor is advised.
Investigation of boron nanosized particles prepared with various surfactants and chitosan in terms of physical stability and cell viability

Nanosuspensions (NS) are one of the new generation drug carrier forms developed to overcome the deficiencies of drugs with poor water solubility or insolubility and are considered to be one of the most successful approaches to formulate compounds in recent years. Boron nitride (BN) is insoluble in water and chemically more stable than carbon, it offers better biological superiority although the application of carbon structures in the biomedical field has increased in recent years. Chitosan is a polymer with excellent processability and biocompatibility thanks to its high dielectric constant. In addition, chitosan has a high affinity for metal ions. This study aims to combine BN and chitosan, which have unique properties, using six different surfactants, and to investigate their long-term stability for the use of both in medicine. In this direction, 24 different BN NS formulations were prepared. The 6th and 12th months’ stability of these formulations were studied at +25 °C, 60% relative humidity, and +4 °C. Also, the prepared formulations were evaluated by cell viability test and examined in terms of toxicity. FTIR spectra of the formulations were taken and their morphologies were characterized by SEM. Prepared NSs with Poloxamer 407 + Tween (N1 − N6) were found to be the most stable formulations for 6 and 12 months both at +4 °C and +25 °C. The fact that BN has a negative zeta potential and chitosan has a high positive zeta potential in formulations is very important in terms of their potential antimicrobial activities. The low cellular toxicity of BN NSs, especially chitosan-coated BN NSs, at higher concentrations shows that they have enormous potential in the diagnosis and treatment of diseases with boron-based compounds in the future.
CORRELATIONS BETWEEN SDSS TYPE Ia SUPERNOVA RATES AND HOST GALAXY PROPERTIES

Studying the correlation of Type Ia supernova rates (SNRs) with host galaxy properties is an important step in understanding the exact nature of Type Ia supernovae (SNe Ia). We use SNe Ia from the SDSS-II sample, spectroscopically determined masses and star formation rates, and a new maximum likelihood method, to fit the Scannapieco and Bildsten rate model SNR = A × M + B × SFR, where M is galaxy mass and SFR is star formation rate. We find A = 3.5+0.9−0.7 × 10−14 (SNe/yr)(M☉)−1 and B = 1.3+0.4−0.3 × 10−3 (SNe/yr)(M☉ yr−1)−1, assuming overall efficiency of 0.5. This is in reasonable agreement with other determinations. However we find strong evidence that this model is a poor fit to other projections of the data: it fails to correctly predict the distribution of supernovae with host mass or SFR. An additional model parameter is required; most likely this parameter is related to host galaxy mass. Some implications of this result are discussed.
Tunable Electronic Property and Robust Type-II Feature in Blue Phosphorene/MoSi2N4 Bilayer Heterostructure

Constructing novel van der Waals heterostructures (vdWHs) is one of the effective methods for expanding the properties and applications of single materials. In this contribution, a blue phosphorene (Blue P)/MoSi2N4 vertical bilayer vdWH was constructed, and its crystal and electronic structures as well as optical properties were systematically studied via first principles calculation. It was found that the Blue P/MoSi2N4 vdWH with good thermal and dynamic stabilities belongs to the type-II indirect bandgap semiconductor with the bandgap of 1.92 eV, which can efficiently separate electrons and holes. Additionally, the two band edges straddle the redox potential of water, and the charge transfer follows the Z-scheme mode, making the Blue P/MoSi2N4 vdWH a promising catalyst of hydrogen production through splitting water. Meanwhile, the Blue P/MoSi2N4 vdWH has higher optical absorption than its two component monolayers. Both the external electric field and vertical strain can easily tailor the bandgap of Blue P/MoSi2N4 vdWH while still preserving its type-II heterostructure characteristics. Our proposed Blue P/MoSi2N4 vdWH is a promising photovoltaic two-dimensional material, and our findings provided theoretical support for the related experimental exploration.
ESTIMATION OF DISSOLVED ORGANIC CARBON IN RIVER FLOWS AND IDENTIFICATION OF THE RELATIONSHIPS BETWEEN PEAT HUMIC FRACTIONS AND PHYSICOCHEMICAL QUALITIES

Peatlands are wetlands that contain higher amounts of carbon, some of which is often released with water in dissolved form, especially when land use change occurs. However, peatland carbon is mostly stabilized in humic fractions where it forms complexes with metallic elements. This study sought to measure the levels of dissolved organic carbon (DOC) in rivers and analyze the link between physicochemical parameters and humic fractions along the Buhandanda and Lushala peat profiles. Inductively-Coupled Plasma Optical Emission Spectrometry, chemical fractionation followed by sulfochromic oxidation, and dosing by indirect chemical oxidation were used to determine major geochemical elements (MGE), humic fractions (HS), and DOC, respectively. Average MGE concentrations were 4.1±1.4, 3.6±0.5, 2.8±0.6, 1.8±0.7, 1.1±0.4, 0.3±0.1, 0.1±0.0, 0.5±0.3, 0.1±0.0, 0.03±0.0, 0.03±0.0 and 1.9±0.9, 3.6±0.8, 2.5±0.6, 2.0±0.5, 1.1±0.4, 0.3±0.0, 0.09±0.01, 0.18±0.1, 0.06±0.04, 0,02±0.0 for Ca, Fe, Si, Al, S, Ti, K, Mg, Mn, Na for Lushala and Buhandanda, respectively. Fulvic acid (FA) fractions were constantly higher than humic acid (HA) from 0 to 80 cm and lower beyond on Buhandanda peaty profile. FA was also higher than HA for Lushala peat except for depths 20, 90, 140, and 200 cm. Humin (HU) was the highest fraction on the two peatlands. Humification index (HI) and degree of transformation (DT) of HS had values of the same order of magnitude (from 0.32 to 2.43). No association was found between physicochemical properties and HS, except for FA and Fe, Ca, S, Mg, Mn, Se on Lushala peat. DOC showed a downward trend from entry to exit of peatlands. The two sites were not statistically different. Mountainous peat can contain high levels of MGE and loses a tiny fraction of its carbon with runoff waters.
Hierarchical Clustering and Trajectory Analyses Reveal Viremia-Independent B-Cell Perturbations in HIV-2 Infection

Time to AIDS in HIV-2 infection is approximately twice as long compared to in HIV-1 infection. Despite reduced viremia, HIV-2-infected individuals display signs of chronic immune activation. In HIV-1-infected individuals, B-cell hyperactivation is driven by continuous antigen exposure. However, the contribution of viremia to B-cell perturbations in HIV-2-infected individuals remains largely unexplored. Here, we used polychromatic flow cytometry, consensus hierarchical clustering and pseudotime trajectory inference to characterize B-cells in HIV-1- or HIV-2-infected and in HIV seronegative individuals. We observed increased frequencies of clusters containing hyperactivated T-bethighCD95highCD27int and proliferating T-bet+CD95highCD27+CD71+ memory B-cells in viremic HIV-1 (p < 0.001 and p < 0.001, respectively), viremic HIV-2 (p < 0.001 and p = 0.014, respectively) and in treatment-naïve aviremic HIV-2 (p = 0.004 and p = 0.020, respectively)-infected individuals, compared to seronegative individuals. In contrast, these expansions were not observed in successfully treated HIV-1-infected individuals. Finally, pseudotime trajectory inference showed that T-bet-expressing hyperactivated and proliferating memory B-cell populations were located at the terminal end of two trajectories, in both HIV-1 and HIV-2 infections. As the treatment-naïve aviremic HIV-2-infected individuals, but not the successfully ART-treated HIV-1-infected individuals, showed B-cell perturbations, our data suggest that aviremic HIV-2-infected individuals would also benefit from antiretroviral treatment.
THERMAL EVOLUTION AND STRUCTURE MODELS OF THE TRANSITING SUPER-EARTH GJ 1214b

The planet GJ 1214b is the second known super-Earth with a measured mass and radius. Orbiting a quiet M star, it receives considerably less mass-loss driving X-ray and UV radiation than CoRoT-7b, so that the interior may be quite dissimilar in composition, including the possibility of a large fraction of water. We model the interior of GJ 1214b assuming a two-layer (envelope+rock core) structure where the envelope material is either H/He, pure water, or a mixture of H/He and H2O. Within this framework, we perform models of the thermal evolution and contraction of the planet. We discuss possible compositions that are consistent with Mp = 6.55 M⊕, Rp = 2.678 R⊕, an age τ = 3–10 Gyr, and the irradiation level of the atmosphere. These conditions require that if water exists in the interior, it must remain in a fluid state, with important consequences for magnetic field generation. These conditions also require the atmosphere to have a deep isothermal region extending down to 80–800 bar, depending on composition. Our results bolster the suggestion of a metal-enriched H/He atmosphere for the planet, as we find water-world models that lack an H/He atmosphere to require an implausibly large water-to-rock ratio of more than 6:1. We instead favor an H/He/H2O envelope with high water mass fraction (∼0.5–0.85), similar to recent models of the deep envelope of Uranus and Neptune. Even with these high water mass fractions in the H/He envelope, generally the bulk composition of the planet can have subsolar water:rock ratios. Dry, water-enriched, and pure water envelope models differ to an observationally significant level in their tidal Love numbers k2 of, respectively, ∼0.018, ∼0.15, and ∼0.7.
ACTIVE AND PASSIVE GALAXIES AT z ∼ 2: REST-FRAME OPTICAL MORPHOLOGIES WITH WFC3

We use the high angular resolution in the near-infrared of the Wide Field Camera 3 (WFC3) on the Hubble Space Telescope to determine YHVz color–color-selection criteria to identify and characterize 1.5 < z < 3.5 galaxies in the Hubble Ultra Deep Field 2009 (HUDF09) and Early Release Science (GOODS-South) fields. The WFC3 NIR images reveal galaxies at these redshifts that were undetected in the rest-frame UV HUDF/GOODS images, as well as true centers and regular disks in galaxies classified as highly irregular in rest-frame UV light. Across the 1.5 < z < 2.15 redshift range, regular disks are unveiled in the WFC3 images of ∼25% of both intermediate and high mass galaxies, i.e., above 1010 M☉. Meanwhile, galaxies maintaining diffuse and/or irregular morphologies in the rest-frame optical light—i.e., not yet dynamically settled—at these epochs are almost entirely restricted to masses below 1011 M☉. In contrast at 2.25 < z < 3.5 these diffuse and/or irregular structures overwhelmingly dominate the morphological mix in both the intermediate and high mass regimes, while no regular disks, and only a small fraction (∼25%) of smooth spheroids, are evident above 1011 M☉. Strikingly, by 1.5 < z < 2.25 roughly two out of every three galaxies at the highest masses are spheroids. In our small sample, the fraction of star-forming galaxies at these mass scales decreases concurrently from ∼60% to ∼5%. If confirmed, this indicates that z ∼ 2 is the epoch of both the morphological transformation and quenching of star formation which assemble the first substantial population of massive ellipticals.
The Impact of Social Isolation, Loneliness, and Technology Use During the COVID-19 Pandemic on Health-Related Quality of Life: Observational Cross-sectional Study

Health-related quality of life (HRQoL), defined as a person’s self-perceived health status in relation to their social, cultural, and environmental context, is linked to better health and the ability to deal with adverse life events [1]. Social factors such as loneliness are known to influence HRQoL negatively [2]. The COVID-19 pandemic has disproportionately impacted older adults, with social distancing measures worsening isolation levels [3], which we hypothesize has resulted in lower levels of HRQoL (hypothesis 1).
Effect of Floor Coatings on Slip-Resistance of Safety Shoes

Slippery flooring often leads to unintentional slips and falls, which results in traumatic injuries. To reduce slipping risks, adequate traction at the shoe and flooring contact is essential. In addition, viscous slippery contaminants like water or oil reduce a floor’s traction performance and increase slipping hazards. In this work, the effect of commonly available protective floor coatings on the traction performance of safety-labelled shoes was extensively studied. The study included three floor coatings, namely acid-based etchant coating, epoxy floor paint, and polyurethane, which were tested across five safety shoes. The coated floorings were tested using a robotic slip-testing device in dry and in the presence of water and machine oil—as separate contaminants. The application of floor coatings produced varying surface roughness for the flooring. Significant traction was generated by the etchant coating for the dry flooring, epoxy coating for the wet flooring, and polyurethane coating for all flooring conditions. A comparison of uncoated and coated floorings showed a high effectiveness of generating traction with epoxy coating on wet flooring and polyurethane coating on both wet and oily conditions. The study results are novel and are anticipated to provide valuable guidelines for the selection of slip-resistant coatings for different slippery floorings, and to reduce risks related to slips and falls.
The state of globular clusters at birth – II. Primordial binaries

In this paper, we constrain the properties of primordial binary populations in Galactic globular clusters. Using the MOCCA Monte Carlo code for cluster evolution, our simulations cover three decades in present-day total cluster mass. Our results are compared to the observations of Milone et al. (2012) using the photometric binary populations as proxies for the true underlying distributions, in order to test the hypothesis that the data are consistent with an universal initial binary fraction near unity and the binary orbital parameter distributions of Kroupa (1995). With the exception of a few possible outliers, we find that the data are to first-order consistent with the universality hypothesis. Specifically, the present-day binary fractions inside the half-mass radius can be reproduced assuming either high initial binary fractions near unity with a dominant soft binary component as in the Kroupa distribution combined with high initial densities (10 4 -10 6 M⊙ pc −3 ), or low initial binary fractions (� 5-10%) with a dominant hard binary component combined with moderate initial densities near their present-day values (10 2 -10 3 M⊙ pc −3 ). This apparent degeneracy can potentially be broken using the binary fractions outside the half-mass radius only high initial binary fractions with a significant soft component combined with high initial densities can contribute to reproducing the observed anti-correlation between the binary fractions outside the half-mass radius and the total cluster mass. We further illustrate using the simulated present-day binary orbital parameter distributions and the technique first introduced in Leigh et al. (2012) that the relative fractions of hard and soft binaries can be used to further constrain both the initial cluster density and the initial mass-density relation. Our results favour an initial mass-density relation of