Miracle-dz/UniFAR-FTUs huggingface dataset:
The Humoral Immune Response of the ChAdOx1 nCoV-19 Vaccine in Maintenance Dialysis Patients without Prior COVID-19 Infection

Background: Chronic kidney disease (CKD) patients tend to have a reduced immune response to infection and vaccination. The efficacy of current available COVID-19 vaccines in CKD patients has not been widely evaluated. Methods: In the present study, three hundred and eight chronic dialysis patients received ChAdOx1 nCoV-19 (Oxford-AstraZeneca, AZ). Blood tests using an antibody against the receptor-binding domain (RBD) of the S1 subunit of the SARS-CoV-2 spike protein had performed at four designed time points before and after the first and second vaccine. Results: The mean age of patients was 65.5 ± 12.38 years, and the male/female ratio was 61.4%:38.6% (189/119). Two weeks after the first vaccination, only 37.66% of patients had a positive antibody response (>50 AU/mL). However, 65.58% of the participants showed a delayed antibody response ten weeks after the first vaccine. Four weeks after the second vaccine, 94.16% of participants had positive antibody levels. Age was the most significant factor associated with antibody response. Flow cytometry analysis revealed that immune-naïve patients had significantly lower early active B cells and proliferative B cells than the age- and sex-matched immune responders. Conclusion: Despite a delayed response, 94.16% of chronic dialysis patients achieved a positive antibody response after two doses of the AZ vaccine. Age is the most significant factor associated with antibody response.
Data-Driven Flow-Map Models for Data-Efficient Discovery of Dynamics and Fast Uncertainty Quantification of Biological and Biochemical Systems

Computational models are increasingly used to investigate and predict the complex dynamics of biological and biochemical systems. Nevertheless, governing equations of a biochemical system may not be (fully) known, which would necessitate learning the system dynamics directly from, often limited and noisy, observed data. On the other hand, when expensive models are available, systematic and efficient quantification of the effects of model uncertainties on quantities of interest can be an arduous task. This paper leverages the notion of flow-map (de)compositions to present a framework that can address both of these challenges via learning data-driven models useful for capturing the dynamical behavior of biochemical systems. Data-driven flow-map models seek to directly learn the integration operators of the governing differential equations in a black-box manner, irrespective of structure of the underlying equations. As such, they can serve as a flexible approach for deriving fast-toevaluate surrogates for expensive computational models of system dynamics, or, alternatively, for reconstructing the long-term system dynamics via experimental observations. We present a data-efficient approach to data-driven flow-map modeling based on polynomial chaos Kriging. The approach is demonstrated for discovery of the dynamics of various benchmark systems and a co-culture bioreactor subject to external forcing, as well as for uncertainty quantification of a microbial electrosynthesis reactor. Such data-driven models and analyses of dynamical systems can be paramount in the design and optimization of bioprocesses and integrated biomanufacturing systems.
Enhancing Dynamic Response of Cantilevered Rectangular Prism Using a Splitter Plate as a Passive Turbulence Control in Water Tunnel

The effects of splitter plate as a passive turbulence control on the transverse vibration characteristics of a cantilevered rectangular prism with the different finite length (aspect ratio L/H) and depth ratios (side ratio D/H of 0.2 and 0.5) was investigated in a water tunnel. A splitter plate was installed behind the prism with a small gap and sufficient length to prevent vortex shedding intrusion. It enhances the response amplitude ascended linearly with respect to non-dimensional velocity. In the case of the prisms with critical points, interferences of amplitude signal spectra for the period of displacement vanished, yielding a uniform waveform on the response amplitude. Inserting a splitter plate improves the increment rate of the dynamic response of the test models. A brief numerical calculation was performed to find the quantities of flow features around a plain and rectangular prism with a detached splitter plate. The alteration of flow wake characteristics is found by diminishing unsymmetrical vortices shedding and reduce flow entrainment at the trailing edge. The essential findings of the prism with a detached splitter plate are the base pressure improvement, reducing drag force, and vanishing sharp peaks of wake FFT spectra.
FAKTOR – FAKTOR YANG BERHUBUNGAN DENGAN PERSEPSI TENAGA KESEHATAN TERHADAP VAKSIN COVID-19 DI PUSKESMAS X TAHUN 2020

The importance of vaccination recommendations for health workers (HCWs) to the public is one of the strongest influencers in vaccination decisions. A preliminary study conducted on ten HCWs concluded that they had different perceptions of the COVID-19 vaccine. Different perceptions are influenced by functional function factors (age, gender, education), sociopsychological factors, and structural factors (knowledge, length of work). The aim of the study was to determine the factors related to the perception of HCWs on the COVID-19 vaccine. This type of research is cross sectional with a quantitative approach. The study was conducted in November 2020 - March 2021. The population and sample were 53 HCWs using total sampling method. Data analysis was performed using univariate and bivariate tests using the chi-square statistical test with α = 0.05. The conclusion shows that health workers with negative perceptions 22 people (41.5%), positive perceptions 31% (58.5%), young people 24 people (45.3%), old age 29 people (54.7%), 33 people (62.3%), 20 male (37.7%), 28 people (52.8%) poor knowledge, 25 good (47.2%), 14 new workyears (26.4%) and 39 long years of service (73.6%). The bivariate analysis showed that there was a relationship between health workers' perceptions of the COVID-19 vaccine with age (p value = 0.048, PR = 2.115), gender (p value = 0.029, PR = 2.727), knowledge (p value = 0.030, PR = 2,381). There is no relationship between perceptions of HCWs and years of service (p value = 0.286, PR = 1.592). It is hoped that agencies will provide more socialization and understanding and involve the active role of HCWs so that negative perceptions can be eliminated, considering that vaccine support from HCWs is urgently needed.
Interplay of environmental cues and wood density in the vegetative and reproductive phenology of seasonally dry tropical forest trees

The great phenological diversification characteristic of seasonally dry tropical forests (SDTF) suggests that these patterns result from a complex interplay between exogenous (e.g., climatic) and endogenous (e.g., morphological, physiological, anatomical) factors. Based on the well‐established relationships of wood density with water‐storing capacity and cavitation vulnerability in woody plants, we hypothesized differential vegetative and reproductive phenological responses to environmental cues for hardwood and softwood species. To test this hypothesis, we compared phenological patterns of pairs of conspecific populations of 10 species differing in wood density, occurring in two localities with slightly different climatic regimes, and evaluated the influence of three environmental variables (rainfall, photoperiod, and temperature) on them. Our results, based on the assessment of the overlap of the phenological curves of conspecific populations occurring in different sites and on linear modeling, showed different effects of the environmental factors on phenophase attributes, depending on wood density of the study species, thus supporting our hypothesis. Leaf out in softwood species took place in the dry season, they shed the foliage at the first signs of drought, and once leafless, they flowered and fruited shortly after. By contrast, hardwood species bore leaves and flowers in the rainy season, shed their leaves several months after the rain ceased, and produced fruits during the dry season. We conclude that the role of environmental variables in cueing growth and reproduction cycles in SDTF tree species is interrelated with their wood density, a key endogenous factor crucially linked to plant hydraulics in these water‐limited ecosystems.
Metabolomic Fingerprinting and Molecular Characterization of the Rock Samphire Germplasm Collection from the Balkan Botanic Garden of Kroussia, Northern Greece

The traditionally edible aerial parts of rock samphire (Crithmum maritimum L.) could be a valuable functional food or feed ingredient due to their high antioxidant capacity, ascorbic acid content, and rich content in secondary metabolites such as phenolics and flavonoids. The first objective of this study was to evaluate eighteen genotypes derived from different regions of Greece regarding the phytochemical contents of their soluble extracts in total phenolics, total flavonoids, and individual polyphenols as determined by LC-MS analysis, as well as ascorbic acid content and their antioxidant capacity as determined by different assays, including ABTS (2,2-azino-bis-3-ethylbenzothiazoline-6-sulfonic acid), DPPH (2,2-diphenyl-1-picrylhydrazyl radical scavenging activity), and FRAP (ferric reducing antioxidant power) assays. The second objective of the study was the molecular characterization of native Greek C. maritimum genotypes. Great variation among genotypes was observed in terms of the antioxidant capacity, ascorbic acid content, and phenolic compounds (total phenolic content and total flavonoid content), as well as in caffeolquinic acids and flavonoids. The principal component analysis highlighted genotypes with a higher potential in antioxidants and polyphenolics. The most promising genotypes were G9 from Kefalonia, followed by G4 from Ikaria, where both clearly exhibited a similar response with high values of evaluated traits. The molecular characterization of genotypes revealed low variability and low to moderate genetic diversity between populations. Our data indicated that the rock samphire germplasm collection from the Balkan Botanic Garden of Kroussia could serve as an important source of documented genetic material and, thus, it is suggested for further investigation to provide insight regarding cultivation and agro-processing aspects, artificial selection, or plant breeding aimed at developing C. maritimum genotypes of high-bioactive value.
Urban Identities in Russian Cities and the Prospects of Their “Smart” Development

This article deals with the urban identity and its connection with the urban dwellers’ willingness to take part in the processes of decisionmaking concerning the future of their cities, their rejection, or, on the contrary, acceptance of the vision of “smart” development promoted by city leaders. The study gives special attention to the gap between the citizens’ perceptions of their cities and the ideal image of their city (perception-expectation gap). The study provides an overview of the contemporary approaches to the concept of “smart city”, and approaches to urban governance and city identity. The study focused on three Russian cities—Tyumen, Tobolsk and Khanty-Mansiysk, located in Tyumen region in Western Siberia. Our surveys were conducted in November 2020 and involved the residents of these cities aged 18 to 70. In total, 877 people were surveyed in Tyumen, 443 people in Tobolsk and 498 people in Khanty-Mansiysk. The questionnaire, which was specially designed for this study, was aimed to measure the residents’ level of attachment to their cities and their perception-expectation gap. Significant differences were revealed between the cities in terms of the strength of their residents’ urban identity, their emotional attachment to their cities, and expectations about their further development. We found that the larger is the perception-expectation gap, the less emotionally attached the citizens are to their cities and the less committed they are to contributing to its future development and prosperity. These research findings can be of interest to urban policy-makers, regional and national governments. The proposed research methodology can be adapted and/or expanded for further cross-city and cross-country analysis.
Center–periphery structure in research communities

Abstract Clustering and community detection in networks are of broad interest and have been the subject of extensive research that spans several fields. We are interested in the relatively narrow question of detecting communities of scientific publications that are linked by citations. These publication communities can be used to identify scientists with shared interests who form communities of researchers. Building on the well-known k-core algorithm, we have developed a modular pipeline to find publication communities with center–periphery structure. Using a quantitative and qualitative approach, we evaluate community finding results on a citation network consisting of over 14 million publications relevant to the field of extracellular vesicles. We compare our approach to communities discovered by the widely used Leiden algorithm for community finding.
The PAP Gene Family in Tomato: Comprehensive Comparative Analysis, Phylogenetic Relationships and Expression Profiles

Purple acid phosphatase (PAP) plays a vital role in plant phosphate acquisition and utilization, as well as cell wall synthesis and redox reactions. In this study, comprehensive comparative analyses of PAP genes were carried out using the integration of phylogeny, chromosomal localization, intron/exon structural characteristics, and expression profiling. It was shown that the number of introns of the PAP genes, which were distributed unevenly on 12 chromosomes, ranged from 1 to 12. These findings pointed to the existence of complex structures. Phylogenetic analyses revealed that PAPs from tomato, rice, and Arabidopsis could be divided into three groups (Groups I, II, and III). It was assumed that the diversity of these PAP genes occurred before the monocot–dicot split. RNA-seq analysis revealed that most of the genes were expressed in all of the tissues analyzed, with the exception of SlPAP02, SlPAP11, and SlPAP14, which were not detected. It was also found that expression levels of most of the SlPAP gene family of members were changed under phosphorus stress conditions, suggesting potential functional diversification. The findings of this work will help us to achieve a better insight into the function of SlPAP genes in the future, as well as enhance our understanding of their evolutionary relationships in plants.
Determinants of food security status of household in Central and North Gondar Zone, Ethiopia

Abstract In rural Ethiopian food, the security status of the household is at the most horrible stage. Ensuring food security in Ethiopia is becoming a great challenge due to different factors. Therefore, the study aimed to identify determinants of food security in the study area. A simple random sampling technique was employed to take 500 sample respondents. Both quantitative and qualitative types of data were collected. Primary data were collected through interview schedule, focus group discussion, and key informant interviews. Household Dietary Diversity Score (HDDS) was used to assess the household’s food security status and a binary logit model was employed to identify the determinants of food security status of a household. The result of the study indicated 38% of households were food secure and 62% of them were food insecure. Access to training, sex, and family size were significant at 10%. The number of oxen, off-farm, farmland size, and age were significant at 5%. However, the tropical livestock unit, livelihood diversification and household on-farm income were significant at 1%. Therefore, since majority of the households were food insecured, appropriate stakeholder selection to support hosehold engagement in different income generating activities as well as providing a timely and adequate supply of agricultural technologies should be considered to improve the existing food security situation.
Influence of the swing ankle angle on walking stability for a passive dynamic walking robot with flat feet

To achieve high walking stability for a passive dynamic walking robot is not easy. In this article, we aim to investigate whether the walking performance for a passive dynamic walking robot can be improved by just simply changing the swing ankle angle before impact. To validate this idea, a passive bipedal walking model with two straight legs, two flat feet, a hip joint, and two ankle joints was built in this study. The walking dynamics that contains double stance phase was derived. By numerical simulation of the walking in MATLAB, we found that the walking performance can be adjusted effectively by only simply changing the swing ankle angle before impact. A bigger swing ankle angle in a reasonable range will lead to a higher walking stability and a lower initial walking speed of the next step. A bigger swing ankle angle before impact leads to a bigger amount of energy lost during impact for the quasi-passive dynamic walking robot which will influence the walking stability of the next step.
Is Social Capital a Key Factor to enhance Firm’s Performance via Manager’s Intangible Capabilities?

Purpose: The purpose of the study is to analyse the role of internal social capital and external social capital in determining the financial and non-financial performance of the firm and the effect of manager’s intangible capabilities on internal social capital and external social capital of firm in the context of the manufacturing sector of India. Design/methodology/approach: The data for this study is collected from 417 managers of manufacturing firms through a structured questionnaire and is analysed through SPSS and AMOS by performing confirmatory factor analysis and structural equation modelling. Findings: Findings reveal that a manager’s business experience, financial literacy and intellectual capital significantly enhance the firm’s internal and external social capital. Furthermore, it has been found that the internal social capital of the firm has the potential to enhance the performance of the firm in financial and non-financial terms. The external social capital also significantly derives from the firm’s financial performance; however, it has not significantly impacted its non-financial performance in the current study. Research limitations/implications: These findings provide many implications in theoretical and practical terms because the literature regarding social capital and the linkage among social capital, intangible capabilities and firm performance will be enhanced. The strategymakers and policymakers can also benefit from this study’s implications for making better strategies and policies regarding social capital and the firm’s performance. Originality/value: Past studies, though, examined the influence of social capital on business performance. However, no prior research addresses the phenomenon through which social capital can determine business performance while undertaking the role of a manager’s intangible capabilities in such a model. Therefore, the current study is the first to study the interrelationship among the manager’s intangible capabilities, social capital, and firm performance.
Burden of Endometriosis: Infertility, Comorbidities, and Healthcare Resource Utilization

The goal of our study was to evaluate the burden of endometriosis in the community by comparing healthcare resource utilization, total direct medical costs, infertility, and comorbidity rates of women with and without a diagnosis of endometriosis. A retrospective case–control study was performed using the databases of a 2.1 million-member nationwide healthcare plan. The study population included women aged 15–55 years enrolled in the healthcare plan. Women with a diagnosis (ICD-9) of endometriosis were compared to controls without diagnosed endometriosis. Women were individually matched (1:4) on age and residence area. Patient characteristics were described, including infertility, comorbidities, and annual healthcare resource utilization. Total direct medical costs were analyzed in a generalized linear model adjusting for age. Women with endometriosis (n = 6146, mean age ± SD: 40.4 ± 8.0 y) were significantly more likely than controls (n = 24,572) to have a lower BMI and a higher socioeconomic status. After adjusting for BMI and socioeconomic status, endometriosis was significantly associated with infertility (OR = 3.3; 95% CI 3.1–3.5), chronic comorbidities, higher utilization of healthcare services (hospitalization: OR = 2.3; 95% CI 2.1–2.5), pain medications, and antidepressants. Women aged 15–19 y with endometriosis had substantially higher utilization of primary care visits (57.7% vs. 14.4%) and oral contraceptive use (76.9% vs. 9.6%). Direct medical costs associated with endometriosis were higher than those for controls (OR = 1.75; 95% CI 1.69–1.85). Endometriosis is associated with a high burden of comorbidities, increased healthcare resource utilization, and excess costs, particularly for younger patients whose healthcare needs may differ widely from the older population.
Modelling the impact of future climate change on streamflow and water quality in Wales, UK

ABSTRACT Climate change is likely to have a major impact on future hydrological regimes, impacting numerous sectors reliant on surface waters. We use the Soil and Water Assessment Tool (SWAT) to model future (2021–2080) streamflow and water quality variables (nitrogen, phosphorus, suspended sediment, and dissolved oxygen), in five catchments in Wales, under a worst-case scenario of future greenhouse gas concentrations (Representative Concentration Pathway 8.5). Results show a decline in annual average flows (−4% to −13%) but larger changes seasonally (spring, up to 41% increase; autumn, up to 52% reduction). The magnitude and frequency of high flow events increasesg in spring (magnitude: Sen’s slope range 0.165–0.589, p < .01), with more low flows in autumn (Sen’s slope range 0.064–0.090, p < .01). Water quality declines, with higher nitrogen, phosphorus, and sediment concentrations and lower dissolved oxygen levels. The findings have economic and environmental implications for abstractors, as water resources could become more unreliable, seasonal, and polluted.
Complying with digital transformation in online booking through experiential values of generation Z

This paper offers insights into experiential values and online accommodation booking in the digital transformation era of the tourism sector in relation to the Greek Generation Z cohort. More specifically, the role of experiential values, attitudes, and involvement as well as their impact on patronage intentions of the Generation Z cohort are investigated. Quantitative research conducted with an online questionnaire yielded a sample of 970 Generation Zers’ responses. Using the Structural Equation Model via the AMOS statistical package, six hypotheses were tested. Results have revealed that the construct of experiential values positively impacts directly on patronage intentions, attitudes towards the e-booking platform, and customer involvement. Additionally, Generation Z members’ attitudes towards the e-booking platform and involvement with the platform impacts patronage intentions. Furthermore, involvement with the e-booking platform has a negative effect on consumers’ attitudes towards the platform. Detailed discussion of results and further implications is also provided.