Miracle-dz/UniFAR-FTUs huggingface dataset:
Two approaches for solving mathematical programs withsecond-order cone complementarity constraints

This paper considers a mathematical program with second-order cone complementarity constrains (MPSOCC). We present two approximation methods for solving the MPSOCC. One employs some smoothing functions to approximate the MPSOCC and the other makes use of some techniques to relax the complementarity constrains in the MPSOCC. We investigate the limiting behavior of both methods. In particular, we show that, under mild conditions, any accumulation point of stationary points of the approximation problems must be a Clarke-type stationary point of the MPSOCC.
Osimertinib-induced Keratitis and Secondary Toxic Epidermal Necrotic Drug Eruption- A Case Report and Literature Review

Background Osimertinib is a third-generation Tyrosine Kinase inhibitor, mainly used in non-small cell lung cancer with EGFR mutation. Its efficacy and safety have been confirmed by clinical practice. Toxic epidermolysis necrotizing disease (TEN) is a severe drug eruption that is rare in clinics and has a high mortality rate. Toxic epidermal necrotic drug rash caused by Osimeritinib is even rarer. Objective To investigate the rare side effects of Osimertinib through a case of toxic Epidermal necrosis Case Presentation A 63-year-old female patient was diagnosed with lung adenocarcinoma with brain metastases, and genetic testing revealed an EGFR21 exon mutation. The disease progressed 24 days after the administration of gefitinib, then the patient switched to Osimertinib (80 mg QD) and, resulting in keratitis and secondary systemic toxic epidermolysis necrotizing disease (TEN). Finally, the patient died. Conclusion Although the clinical use of osimertinib is becoming widespread, the side effects may not be fully understood. Clinicians should pay more attention to the occurrence of the side reaction and deal with it in time.
Cellular redox homeostasis maintained by malic enzyme 2 is essential for MYC-driven T cell lymphomagenesis

Significance The overall prognosis for T cell lymphoma (TCL) patients remains poor due to the rarity and heterogeneity of this disease. Oncogenic transcription factor MYC is critical to the development of a large proportion of TCL patients. Constitutive MYC overexpression leads to TCL tumor initiation and progression, while MYC depletion slows down tumor growth. However, it remains unclear how MYC functions to promote T cell lymphomagenesis. We report here that malic enzyme 2 (ME2) promotes MYC-driven T cell lymphomagenesis by maintaining redox homeostasis. Breaking MYC–ME2 circuit with rapamycin alleviates TCL progression in patients with high MYC expression.
Association of anandamide and 2-arachidonoylglycerol concentrations with clinical features and body mass index in eating disorders and obesity

Abstract Background Anandamide (AEA) and 2-arachidonoylglycerol (2-AG) play a pivotal role in stimulating motivational behavior toward food and energy metabolism. Aberrant functioning of the endocannabinoid system has been observed in extreme weight conditions (EWCs), suggesting it may influence pathophysiology. Then, we aimed to analyze fasting AEA and 2-AG plasma concentrations among individuals with EWC (i.e., anorexia nervosa [AN] and obesity with and without eating disorders [EDs]) compared with healthy controls (HCs), and its association with clinical variables and body mass index (BMI). Methods The sample included 113 adult women. Fifty-seven belonged to the obesity group, 37 without EDs (OB-ED) and 20 with ED (OB+ED classified within the binge spectrum disorders), 27 individuals from the AN group, and 29 from the HC group. Peripheral blood samples, several clinical variables, and BMI were evaluated. Results Unlike 2-AG, AEA concentrations showed significant differences between groups (p < 0.001). Increased AEA was observed in the OB-ED and OB+ED compared with both HC and AN group, respectively. Likewise, AEA was differentially associated with emotional dysregulation, general psychopathology, food addiction, and BMI in all clinical groups. Conclusions These results support the interaction between biological and clinical factors contributing to delineating vulnerability pathways in EWC that could help fit personalized therapeutic approaches.
The MIF promoter SNP rs755622 is associated with immune activation in glioblastoma

Intratumoral heterogeneity is a defining hallmark of glioblastoma, driving drug resistance and ultimately recurrence. Many somatic drivers of microenvironmental change have been shown to affect this heterogeneity and, ultimately, the treatment response. However, little is known about how germline mutations affect the tumoral microenvironment. Here, we find that the single-nucleotide polymorphism (SNP) rs755622 in the promoter of the cytokine macrophage migration inhibitory factor (MIF) is associated with increased leukocyte infiltration in glioblastoma. Furthermore, we identified an association between rs755622 and lactotransferrin expression, which could also be used as a biomarker for immune-infiltrated tumors. These findings demonstrate that a germline SNP in the promoter region of MIF may affect the immune microenvironment and further reveal a link between lactotransferrin and immune activation.
Preferences for Rectal Sexually Transmitted Infection Sample Collection and Sexual Behaviors Among Adolescent and Young Adult Women Accessing Primary Care Services

A study of women in an adolescent outpatient clinic found that most participants engage in behaviors putting them at risk for extragenital sexually transmitted infections and prefer to self-collect rectal swabs in the doctor's office. Background High prevalence of asymptomatic rectal chlamydia and gonorrhea among women is increasingly recognized. Screening is controversial because of lack of natural history data. Barriers to screening may include reluctance to discuss anal sex and collect rectal samples. This study describes the prevalence of sexual contact exposing adolescent and young adult women to extragenital sexually transmitted infections and acceptability of self-collection and clinician collection of rectal samples, preference for self- versus clinician-collected rectal samples, and preference for home or doctor's office for sample collection. Methods Participants were recruited from a primary care office and completed structured interviews assessing types of sexual contact and attitudes about rectal sampling. Differences were tested using χ2 and 2-sided Fisher exact test. Results Of 110 cisgender women (aged 14–22 years) enrolled, the average age was 18.4 years (SD, 1.7 years), 83% reported a history of extragenital contact, 22% reported history of receptive anal intercourse. A majority of participants reported self- and clinician-collected rectal samples to be acceptable (86% and 73%, respectively), with preferences for self-collection (71%) over clinician collection (29%, P < 0.001) and collection at the doctor's office (85%) over home (15%, P < 0.001). Conclusions Adolescent and young adult (AYA) women engage in behaviors that increase the risk of rectal sexually transmitted infection (STI). Self- and clinician-collected rectal samples were acceptable. A majority of AYA women preferred to collect rectal samples in the doctor's office rather than at home. This may reduce adolescents' access to direct-to-consumer STI services. Offering in-clinic, self-collected rectal samples may improve uptake of rectal STI screening in adolescent girls.
Disruption of neurosteroid synthesis and release by tris(2,3‐dibromopropyl)isocyanurate in primary mouse cortical astrocytes in vitro

Neurosteroidogenesis in astrocytes is crucial for the proper development and functioning of the brain. During this process, key neurohormones such as progesterone (P4), testosterone (T), and estradiol (E2) are produced. Proper production and release of neurosteroids can be affected by substances referred to as endocrine‐disrupting compounds (EDCs). Tris‐(2,3‐dibromopropyl)isocyanurate (TBC) is a representative of novel brominated flame retardants used to stop ignition or reduce fire‐related property damage to plastics, polyolefin, polyphenyl alkene, unsaturated polyester, synthetic rubber, and fibers. Interestingly, previous studies have shown that TBC can enhance the proliferation of estradiol‐sensitive breast cancers in vitro, which suggests that TBC has EDC properties. Therefore, given the suspected endocrine‐disrupting properties of TBC, the aim of the present study was to determine the impact of TBC on the neurosteroid (P4, T, and E2) production and secretion as well as the mRNA expression of key enzymes involved in its production in mouse astrocytes in vitro. Our paper shows that TBC increases P4 production with a strong decrease in T production, which is accompanied by a decrease in Cyp17a1 mRNA expression, that is, the main enzyme metabolizing P4 to T. Moreover, TBC in both studied concentrations increases P4 secretion in the culture medium. Finally, our studies have demonstrated an increase in the expression of Cyp19a1 mRNA, an enzyme metabolizing T to E2, with a simultaneous increase in the amount of E2 in cells. Our data clearly show that TBC in an in vitro environment acts as EDCs, which may lead to serious consequences for the proper development and functioning of the brain.
Effect of a 6-Wk Sensory-Motor Exercise Program on the Balance and Fatigue Severity in Women With Multiple Sclerosis

Objective This study aimed to investigate the impact of 6 wks of at-home sensory-motor exercises on balance and fatigue levels in women with multiple sclerosis, a progressive autoimmune disease affecting the central nervous system. Multiple sclerosis symptoms can significantly reduce quality of life. Design In this quasi-experimental study, 26 female patients with multiple sclerosis aged 20–40 yrs with an expanded disability status scale of 0–4 were randomly assigned to control and experimental groups. The experimental group performed sensory-motor exercises for 6 wks, three sessions a week, and for 1 hr at home. Balance and fatigue were evaluated with Sharpened-Romberg tests (for static balance), a 6-step test of Get-Up and Go (for dynamic balance), and a Fatigue Severity Scale. At the end of the sixth week, these tests were re-evaluated like the pretest stage. Results Experimental group showed better static balance and Fatigue Severity Scale than control group, but no difference in dynamic balance. Conclusions Considering the outbreak of COVID-19 and the resultant lockdown, the importance of exercise and physical activities in patients with multiple sclerosis, and the positive effects of sensory-motor exercises at home in the present study, these kinds of sensory-motor workouts are highly recommended to improve balance and reduce the fatigue in patients with multiple sclerosis.
Malignant Self-Regard as an Overarching Framework for the Theory and Treatment of Depressive and Masochistic (Self-Defeating) Personalities

Abstract Kernberg and McWilliams have spawned differing conceptualizations of the relationship between depressive and masochistic (self-defeating) personalities. Kernberg describes these personality styles as largely overlapping in features, whereas McWilliams accentuates important clinical differences that make up two distinct personalities. In this article, their theoretical perspectives are discussed and framed as more complementary than competitive. The malignant self-regard (MSR) construct is introduced and reviewed as an integrative self-representation that is shared by both depressive and masochistic personalities, as well as those often referred to as vulnerably narcissistic. We investigate developmental conflicts, motivations for perfectionism, countertransference patterns, and overall level of functioning as four primary clinical features through which a therapist may differentiate a depressive from a masochistic personality. We argue that depressive personalities tend to have more dependency-related conflicts and perfectionistic strivings motivated by lost object reunification, elicit more insidiously positive countertransference reactions in session, and are generally higher-functioning individuals. Masochistic personalities have more oedipal-related conflicts and perfectionistic strivings motivated by object control, elicit more aggressive countertransference reactions, and are relatively lower functioning. MSR is positioned as a bridge between Kernberg's and McWilliam's ideas. We close with a discussion of treatment implications for both disorders as well as how to understand and treat MSR.
Forecasting Evolution of Clusters in Game Agents with Hebbian Learning

Large multi-agent systems such as real-time strategy games are often driven by collective behavior of agents. For example, in StarCraft II, human players group spatially near agents into a team and control the team to defeat opponents. In this light, clustering the agents in the game has been used for various purposes such as the efficient control of the agents in multi-agent reinforcement learning and game analytic tools for the game users. However, despite the useful information provided by clustering, learning the dynamics of multi-agent systems at a cluster level has been rarely studied yet. In this paper, we present a hybrid AI model that couples unsupervised and self-supervised learning to forecast evolution of the clusters in StarCraft II. We develop an unsupervised Hebbian learning method in a set-to-cluster module to efficiently create a variable number of the clusters with lower inference time complexity than K-means clustering. Also, a long short-term memory based prediction module is designed to recursively forecast state vectors generated by the set-to-cluster module to define cluster configuration. We experimentally demonstrate the proposed model successfully predicts complex movement of the clusters in the game.
Contextual Vision Transformers for Robust Representation Learning

We introduce Contextual Vision Transformers (ContextViT), a method designed to generate robust image representations for datasets experiencing shifts in latent factors across various groups. Derived from the concept of in-context learning, ContextViT incorporates an additional context token to encapsulate group-specific information. This integration allows the model to adjust the image representation in accordance with the group-specific context. Specifically, for a given input image, ContextViT maps images with identical group membership into this context token, which is appended to the input image tokens. Additionally, we introduce a context inference network to predict such tokens on-the-fly, given a batch of samples from the group. This enables ContextViT to adapt to new testing distributions during inference time. We demonstrate the efficacy of ContextViT across a wide range of applications. In supervised fine-tuning, we show that augmenting pre-trained ViTs with our proposed context conditioning mechanism results in consistent improvements in out-of-distribution generalization on iWildCam and FMoW. We also investigate self-supervised representation learning with ContextViT. Our experiments on the Camelyon17 pathology imaging benchmark and the JUMP-CP microscopy imaging benchmark demonstrate that ContextViT excels in learning stable image featurizations amidst distribution shift, consistently outperforming its ViT counterpart.
Understanding brain functional architecture through robotics

Robotics is increasingly seen as a useful test bed for computational models of the brain functional architecture underlying animal behavior. We provide an overview of past and current work, focusing on probabilistic and dynamical models, including approaches premised on the free energy principle, situating this endeavor in relation to evidence that the brain constitutes a layered control system. We argue that future neurorobotic models should integrate multiple neurobiological constraints and be hybrid in nature. Description Robot control models with layered architectures and parts that minimize free energy may elucidate the workings of the brain.
Glasgow coma scale pupil score (GCS-P) and the hospital mortality in severe traumatic brain injury: analysis of 1,066 Brazilian patients

Abstract Background Pupil reactivity and the Glasgow Coma Scale (GCS) score are the most clinically relevant information to predict the survival of traumatic brain injury (TBI) patients. Objective We evaluated the accuracy of the GCS-Pupil score (GCS-P) as a prognostic index to predict hospital mortality in Brazilian patients with severe TBI and compare it with a model combining GCS and pupil response with additional clinical and radiological prognostic factors. Methods Data from 1,066 patients with severe TBI from 5 prospective studies were analyzed. We determined the association between hospital mortality and the combination of GCS, pupil reactivity, age, glucose levels, cranial computed tomography (CT), or the GCS-P score by multivariate binary logistic regression. Results Eighty-five percent ( n = 908) of patients were men. The mean age was 35 years old, and the overall hospital mortality was 32.8%. The area under the receiver operating characteristic curve (AUROC) was 0.73 (0.70–0.77) for the model using the GCS-P score and 0.80 (0.77–0.83) for the model including clinical and radiological variables. The GCS-P score showed similar accuracy in predicting the mortality reported for the patients with severe TBI derived from the International Mission for Prognosis and Clinical Trials in TBI (IMPACT) and the Corticosteroid Randomization After Significant Head Injury (CRASH) studies. Conclusion Our results support the external validation of the GCS-P to predict hospital mortality following a severe TBI. The predictive value of the GCS-P for long-term mortality, functional, and neuropsychiatric outcomes in Brazilian patients with mild, moderate, and severe TBI deserves further investigation.
Identifying the risk factors for intracranial herniation in patients with cerebral venous thrombosis

Abstract Background Cerebral venous sinus thrombosis (CVST) is not as well understood as an ischemic stroke of arterial origin. Although the prognosis of CVST is usually good, parenchymal lesions may occur in some patients, and the development of intracranial herniation may result in death. For this reason, recognizing the risk factors for intracranial herniation and accurately determining those patients who should undergo decompressive craniectomy is important. Objective This study aims to determine the risk factors for intracranial herniation in patients with CVST. Methods A total of 177 patients diagnosed with CVST between 2015 and 2021 in our tertiary center were retrospectively included in this study. Results Of the 177 patients, 124 were female and 53 were male with mean ages of 40.65 ± 13.23 and 44.13 ± 17.09, respectively. Among those, 18 patients had developed intracranial herniation. A significant statistical relationship was observed between superior sagittal sinus thrombosis, sinus rectus thrombosis, venous collateral score, nonhemorrhagic venous infarct, presence of malignancy, small juxtacortical hemorrhage, and cortical vein thrombosis. The binary logistic regression analysis results showed that the most significant variables were the venous collateral score of 0, malignancy, and small juxtacortical hemorrhages. Conclusion This study identified small juxtacortical hemorrhages, the presence of malignancy, and a venous collateral score of 0 to be independent risk factors for intracranial herniation in CVST patients. Drawing on these results, we recommend close clinical observation of CVST patients, as they may be candidates for decompressive craniectomy.
Scintillation behaviour of vortex beams in strong turbulence region

Abstract We study the scintillation behaviour of vectorial vortex beams in strong turbulence region. For this purpose, a list of vortex source beams is prepared. Then their scintillation performances are analysed one by one using the random phase screen approach. The results indicate that there will always be scintillation reductions with increasing values of topological charge, although its effect will diminish as we go towards higher values of the topological charge. The increases in the other specific beam parameters seem to have opposite effect. For the vectorial Hermite Gaussian beam, the use of higher orders will also aid scintillation reductions. It is foreseen that the outcome of this study will be useful for long haul optical communication links.
Prediction model of adjacent vertebral compression fractures after percutaneous kyphoplasty: a retrospective study

Objectives The purpose of this study was to develop a prediction model to assess the risk of adjacent vertebral compression fractures (AVCFs) after percutaneous kyphoplasty (PKP) surgery. Design A retrospective chart review. Setting and participants Patients were collected from the Quzhou People’s Hospital, from March 2017 to May 2019. Patients were included if they suffered from osteoporotic vertebral compression fractures (OVCFs), underwent PKP surgery and were followed up for 2 years. Interventions None. Methods This was a retrospective cohort study of all PKP surgery procedures of the thoracic, lumbar and thoracolumbar (TL) spine that have been performed for OVCF from 1 March 2017 up to 1 May 2019. The least absolute shrinkage and selection operator (LASSO) regression model was used to optimise feature selection for the AVCF risk model. Multivariable logistic regression analysis was applied to build a predicting model incorporating the feature selected in the LASSO regression model. The C-index, calibration plot and decision curve analysis were applied to assess this model. Results Gender, age, the number of surgical vertebrae, cement volume, bone mineral density, diabetes, hypertension, bone cement leakage, duration of anti-osteoporosis treatment after surgery and TL junction were identified as predictors. The model displayed good discrimination with a C-index of 0.886 (95% CI 0.828–0.944) and good calibration. High C-index value of 0.833 could still be reached in the interval validation. Decision curve analysis showed that the AVCF nomogram was clinically useful when intervention was decided at the AVCF possibility threshold of 1%. Conclusions This study developed a clinical prediction model to identify the risk factors for AVCF after PKP surgery, and this tool is of great value in sharing surgical decision-making among patients consulted before surgery. Trial registration number researchregistry7716.
Applying Hazard Pointers to More Concurrent Data Structures

Hazard pointers is a popular semi-manual memory reclamation scheme for concurrent data structures, where each accessing thread announces protection of each object to access and validates that the pointer is not already freed. Validation is typically done by over-approximating unreachability: if an object seems to be unreachable from the root of the data structure, the protecting thread decides not to access the object as it might have been freed. However, many efficient data structures are incompatible with validation by over-approximation as their optimistic traversal strategy intentionally ignores the warning of unreachability to achieve better performance. We design HP++, an extension to hazard pointers that supports optimistic traversal. The key idea is under-approximating unreachability during validation and patching up the potentially unsafe accesses arising from false-negatives. Thanks to optimistic traversal, data structures with HP++ outperform the same-purpose data structures with HP under contention, while consuming a similar amount of memory.