Miracle-dz/UniFAR-FTUs huggingface dataset:
Dynamic thermal imaging for pigmented basal cell carcinoma and seborrheic keratosis

Abstract Background Clinical differentiation between pigmented basal cell carcinoma (BCC) and seborrheic keratosis (SK) can sometimes be difficult. Noninvasive diagnostic technologies, such as thermal imaging, can be helpful in these situations. This study explored the use of dynamic thermal imaging (DTI), which records thermal images after the application of external thermal stimuli (heat or cold) for the differential diagnosis of pigmented BCC and SK. Materials and methods Twenty-two patients with pigmented BCC and 15 patients with SK participated in this study. Dynamic thermal images of lesions (pigmented BCC or SK) and control sites (contralateral normal skin) were recorded after the heat and cold stimuli. Temperature changes in the region of interest (ROI) are plotted as a thermal response graph. After fitting an exponential equation to each thermal response graph, the rate constants were compared between groups (pigmented BCC versus control, SK versus control). Results The thermal response graphs revealed that the average temperature of pigmented BCC showed faster thermal recovery to baseline than the control site. There was a significant difference in the rate constants of the fitted exponential equations between the pigmented BCCs and the control sites (p<.001). However, we did not find a significantly different thermal recovery pattern between SK lesions and control sites. Conclusions DTI can be used as a diagnostic tool for distinguishing pigmented BCC from SK by comparing thermal recovery patterns between target lesions (pigmented BCC or SK) and the control site.
Excessive polypharmacy and potentially inappropriate prescribing in 147 care homes: a cross-sectional study

Background Care home residents often have multiple cognitive and physical impairments, and are at high risk of adverse drug events (ADEs). Aim To describe excessive polypharmacy and potentially inappropriate prescribing predisposing care home residents to ADEs. Design & setting A cross-sectional analysis of all dispensed prescriptions for 147 care home residents in Tayside and Fife, Scotland. Method Prevalence of excessive polypharmacy was examined using multilevel logistic regression, by modelling associations between individual and care home predictors with excessive polypharmacy (≥10 drugs). Prescribing of drugs known to increase the risk of eight clinically important ADE categories was examined. Drugs prescribed within each ADE category, for each resident, were counted. Results In total, 32.3% (n = 1444/4468) of residents had excessive polypharmacy, which was more common in residents aged 70–74 years (adjusted odds ratio [aOR] 1.86, 95% confidence interval [CI] = 1.04 to 3.34) and 80–84 years (aOR 1.75, 95% CI = 1.01 to 3.02), living in a residential care home (aOR 1.50, 95% CI = 1.19 to 1.88), and located in Fife (aOR 1.37, 95% CI = 1.09 to 1.71). Excessive polypharmacy was less common in residents with dementia (aOR 0.73, 95% CI = 0.64 to 0.84), and 8.9% (95% CI = 5.9% to 11.6%) of the variation was attributable to care home predictors. Potentially inappropriate prescribing of ≥2 drugs was seen across all ADE categories, with highest prevalence seen in drugs predisposing to constipation (35.8%), sedation (27.7%), and renal injury (18.0%). Conclusion Excessive polypharmacy is common in care home residents and is associated with both individual and care home predictors. Potentially inappropriate prescribing of drugs that predisposed residents to all included ADE categories is common. Research is needed to support and evaluate safe care home prescribing practices.
Dental Erosion: Effect of Diet Drink Consumption on Permanent Dentition

Objective: The aim of this study is to examine the effect of diet drinks on dental erosion among a representative sample of US adults. Methods: Adult dietary and dental data were analyzed from the 2003–2004 cycle of the National Health and Nutrition Examination Survey. Erosion was measured with a modified tooth wear index and was analyzed as a dichotomous variable. Cluster analysis was performed, and the cluster number was based on having a separate diet drink cluster and the R2 values. Survey procedure and sample weights were used. Results: Most of the population (80%) had some form of dental erosive lesions. When compared with the total sample, people with erosion were more likely to be male (52.5%) and older. People with no erosive lesions were younger (42.3%) and non-Hispanic Black (21.2%). Cluster analysis resulted in 4 distinct clusters: high water, high diet drinks, high coffee/tea, and high soda. The respective percentage of individuals in each cluster who had erosion was 78.9%, 85%, 83.9%, and 76.2%, where the “high diet drinks” cluster showed the highest erosion (P = 0.28). Logistic regression modeling showed that the “high diet drinks” cluster had increased odds of erosion (odds ratio = 1.27; 95% CI = 0.58 to 2.77) when compared with the “high water” cluster, but the relationship was not statistically significant. Conclusion: High diet drinks consumption slightly increased the odds of dental erosion among US adults, although this relationship was not statistically significant. It is thus not yet clear that dentists should recommend diet drinks, as they might be linked to systemic diseases. Further research is needed to explore more about risk factors of erosion. Knowledge Transfer Statement: The findings of this study are suggestive, though not significantly, that diet drinks may increase risk for dental erosion. While further research is needed, it is not clear that dentists should recommend these drinks as healthy substitutes for sugary drinks.
Spinal cord pathology revealed by MRI in traumatic spinal cord injury

Purpose of review This review covers recent advances in identifying conventional and quantitative neuroimaging spinal cord biomarkers of lesion severity and remote spinal cord pathology following traumatic spinal cord injury (SCI). It discusses the potential of the most sensitive neuroimaging spinal cord biomarkers to complement clinical workup and improve prediction of recovery. Recent findings At the injury site, preserved midsagittal tissue bridges – based on conventional sagittal T2-weighted scans – can be identified in the majority of SCI patients; its width being predictive of recovery. Remote from the injury, diffusion indices, and myelin/iron-sensitive neuroimaging-based changes are sensitive to secondary disease processes; its magnitude of change being associated with neurological outcome. Summary Neuroimaging biomarkers reveal focal and remote cord pathology. These biomarkers show sensitivity to the underlying disease processes and are clinically eloquent. Thus, they improve injury characterization, enable spatiotemporal tracking of cord pathology, and predict recovery of function following traumatic SCI. Neuroimaging biomarkers, therefore, hold potential to complement the clinical diagnostic workup, improve patient stratification, and can serve as potential endpoints in clinical trials.
The Efficacy and Cognitive Effects of Acute Course Electroconvulsive Therapy Are Equal in Adolescents, Transitional Age Youth, and Young Adults.

Objective: Electroconvulsive therapy (ECT) is the most effective acute treatment for depression, but its use in younger patients is rare and heavily regulated in many U.S. states. It is unclear whether age modifies treatment response or tolerability in adolescents, transitional age youth, and young adults. We examined the effects of ECT on depression and cognition in patients aged 16-30 years. Methods: A retrospective cohort study of patients aged 16-30 years receiving ECT between 2011 and 2020 who were evaluated with the Quick Inventory of Depressive Symptomatology (QIDS), the Behavior and Symptom Identification Scale-24 (BASIS-24), and the Montreal Cognitive Assessment (MoCA) at baseline and following treatment #10. Results: Among the 424 patients who met the inclusion criteria, ECT was associated with a decrease in depression symptoms (ΔQIDS -6.7; Kruskal-Wallis rank sum test; χ2 = 293.37; df = 2; p < 0.0001) and improvement in overall self-reported mental health status (ΔBASIS-24 - 0.70; Kruskal-Wallis rank sum test; χ2 = 258.5; df = 2; p < 0.0001) during the first 10 treatments, with a slight reduction in cognition as measured by the MoCA (ΔMoCA -1.1; Kruskal-Wallis rank sum test; χ2 = 33.7; df = 1; p < 0.0001). Age was not a significant predictor of QIDS, BASIS-24, or MoCA changes. Conclusions: Among 424 patients aged 16-30 years receiving acute course ECT, age was not a significant predictor of improvement in depression, change in overall self-reported mental health status, or change in cognition. These results support the utility of ECT in the treatment of adolescents and young adults.
Irreversible depletion of intestinal CD4+ T cells is associated with T cell activation during chronic HIV infection

HIV infection in the human gastrointestinal (GI) tract is thought to be central to HIV progression, but knowledge of this interaction is primarily limited to cohorts within Westernized countries. Here, we present a large cohort recruited from high HIV endemic areas in South Africa and found that people living with HIV (PLWH) presented at a younger age for investigation in the GI clinic. We identified severe CD4+ T cell depletion in the GI tract, which was greater in the small intestine than in the large intestine and not correlated with years on antiretroviral treatment (ART) or plasma viremia. HIV-p24 staining showed persistent viral expression, particularly in the colon, despite full suppression of plasma viremia. Quantification of mucosal antiretroviral (ARV) drugs revealed no differences in drug penetration between the duodenum and colon. Plasma markers of gut barrier breakdown and immune activation were elevated irrespective of HIV, but peripheral T cell activation was inversely correlated with loss of gut CD4+ T cells in PLWH alone. T cell activation is a strong predictor of HIV progression and independent of plasma viral load, implying that the irreversible loss of GI CD4+ T cells is a key event in the HIV pathogenesis of PLWH in South Africa, yet the underlying mechanisms remain unknown.
An Investigation of the CK2-dependent Phosphoproteome using Inhibitor Refractory CK2-alpha

Protein kinase CK2 is a constitutively active serine/threonine kinase that is overexpressed in several human cancers, and by virtue of the vast number of putative substrates in the phosphoproteome, is implicated in the regulation of numerous cellular processes. Consequently, CK2 is an emerging therapeutic target with many CK2 inhibitors having been developed. An example of one such inhibitor is the clinical stage compound CX4945. Although highly selective for CK2, the ATP competitive CX-4945 has demonstrated affinity for other kinases. Unique features of the catalytic pocket of CK2 have allowed for the development of inhibitor refractory mutants, which have since been stably integrated into tetracycline inducible osteosarcoma cell lines. A mass spectrometry-based phosphoproteomic workflow was used in conjunction with inhibitor refractory cell lines to study the impact of CK2 inhibition on the phosphoproteome, and potentially identify off-targets of the clinical compound CX-4945. In response to CX-4945 treatment the inhibitor refractory mutant recovered phosphorylation at several sites, revealing potential novel substrates of CK2. Phosphoproteomic analysis also revealed potential off-targets of CX-4945. This investigation provides valuable insight into the role played by CK2 in cellular signaling and provides a platform for downstream targeted proteomic analysis of CK2.
S-NPP/NOAA-20 VIIRS reflective solar bands on-orbit calibration bias investigation

The Visible-Infrared Imaging Radiometer Suite (VIIRS) is a primary sensor on-board the Suomi-National Polar-orbiting Partnership (S-NPP) and National Oceanic and Atmospheric Administration 20 (NOAA-20) spacecrafts, launched in October 2011 and November 2017, respectively. VIIRS has 22 bands: 7 thermal emissive bands (TEBs), 14 reflective solar bands (RSBs) and a Day Night Band (DNB). Both the RSBs and TEBs use a combination of pre-launch and on-orbit calibration information to provide accurate radiance, reflectance, and brightness temperature Sensor Data Records (SDRs). An on-orbit comparison of the S-NPP and NOAA-20 RSB SDR radiances, using ground calibration sites and vicarious methods such as deep convective clouds, show that there is a ~2% bias between the two sensors for all the reflective solar bands. Additionally, the M5 (0.672 μm) and M7 (0.865 μm) bands of Suomi NPP VIIRS have larger biases. An investigation of each sensor’s pre-launch and on-orbit calibrations was performed to ascertain the root cause of the sensor-to-sensor bias. This paper will discuss the VIIRS methodologies for both pre-launch and on-orbit calibration and how they affect the SDR product performance, as well as the most likely cause for the bias . In particular, the characterization of the reflectance of the Solar Diffuser and its reflectance variation versus view geometry was performed with different methodologies for S-NPP and NOAA-20 VIIRS. It is anticipated that J2, J3 and J4 VIIRS sensors will behave more similarly to NOAA-20 than S-NPP VIIRS due to the methodology for the SD characterization being consistent with NOAA-20.
Design and characterization of the damage induced by irradiation in optical coatings for space applications

A systematic characterization of dielectric coatings for space application is carried out to evaluate the performance drop upon protons exposure. Different energy levels and fluence values are tested. Also, since the irradiation experiments are performed in large scale facilities, different flux rates are tested to establish the operational parameters that better mimic the real irradiation conditions. The induced damage associated with each irradiation session is characterized for a selection of single and bi-layer coatings. Results show that the performance drop is highly dependent on the fluence and the implantation energy.
Goals and feasibility of the deep space quantum link

In this article, we review the proposed experiments for the Deep Space Quantum Link (DSQL) mission concept aiming to probe gravitational effects on quantum optical systems. Quantum theory and general relativity are the two most successful frameworks we have to describe the universe. These theories have been validated through experimental confirmations in their domains of application— the macroscopic domain for relativity, and the microscopic domain for quantum theory. To date, laboratory experiments conducted in a regime where both theories manifest measurable effects on photons are limited. Satellite platforms enable the transmission of quantum states of light between different inertial frames and over distances impossible to emulate in the laboratory. The DSQL concept proposes simultaneous tests of quantum mechanics and general relativity enabled by quantum optical links to one or more spacecrafts.
Transfer Pricing Audit Challenges and Dispute Resolution Effectiveness in Developing Countries with Specific Focus on Zimbabwe

Abstract Base erosion and profit shifting activities of multinational enterprises (MNEs) have been a hot issue globally. Topical among the strategies employed by MNEs has been the issue of transfer pricing (TP). Developing countries are argued to be significantly affected by TP manipulation resulting in substantial tax revenues being lost. As a response to curb the unfavourable impacts of transfer mispricing, most developing countries have adopted the OECD TP guidelines and enacted TP legislation to regulate TP activities. The arm’s length principle is the core of TP legislation, yet it has brought challenges for tax administrators and their auditors in enforcing and assessing compliance respectively leading to disputes. In view of the ever-changing business world and continuous efforts by MNEs to minimise their tax obligations through income shifting, it was imperative to assess the factors affecting the effectiveness of TP audits and dispute resolutions as measures to enhance compliance and enforcement in developing countries, with specific reference to Zimbabwe. Findings include the lack of clarity in TP legislation, resource constraints and complexity of transactions, lack of expertise as well as the shortage of comparable data. Developing countries are encouraged to formulate clear TP regulations and invest in the capacitation of revenue authorities.
Impact of temperature dependent viscosity and thermal conductivity on MHD blood flow through a stretching surface with ohmic effect and chemical reaction

Abstract A study has been carried for a viscous, incompressible electrically conducting MHD blood flow with temperature-dependent thermal conductivity and viscosity through a stretching surface in the presence of thermal radiation, viscous dissipation, and chemical reaction. The flow is subjected to a uniform transverse magnetic field normal to the flow. The governing coupled partial differential equations are converted into a set of non-linear ordinary differential equations (ODE) using similarity analysis. The resultant non-linear coupled ordinary differential equations are solved numerically using the boundary value problem solver (bvp4c) in MATLAB with a convincible accuracy. The effects of the physical parameters such as viscosity parameter (μ(T˜b)) \left({\mu ({{\tilde T}_b})} \right) , permeability parameter (β), magnetic field parameter (M), Local Grashof number (Gr) for thermal diffusion, Local modified Grashof number for mass diffusion (Gm), the Eckert number (Ec), the thermal conductivity parameter (K(T˜b)) \left({K({{\tilde T}_b})} \right) on the velocity, temperature, concentration profiles, skin-friction coefficient, Nusselt number, and Sherwood number are presented graphically. The physical visualization of flow parameters that appeared in the problem is discussed with the help of various graphs to convey the real life application in industrial and engineering processes. A comparison has been made with previously published work and present study revels the good agreement with the published work. This study will be helpful in the clinical healing of pathological situations accompanied by accelerated circulation.
The effects of saffron petals and damask rose petals on biochemical and inflammatory measurements

Abstract Objectives Diabetes is a chronic disease caused by high blood sugar greatly affected by diet. The chemical medicines applied to treat diabetes usually have side effects. This study aimed to investigate the effect of saffron petals, damask rose petals, and saffron-damask rose petal herbal teas on weight loss, fasting blood sugar, lipid profile, and the inflammatory factors of diabetic rats. Methods In this study, 40 male Sprague Dawley rats with an average age of four weeks received a high-calorie, high-fat, high-sugar diet for nine weeks. The rats were then randomly assigned to five groups, including normal, control, saffron petal, damask rose petal, and saffron plus damask rose petal groups. For nine weeks, 3 mL of the herbal tea was administered to the intervention groups daily through oral gavage. The levels of FBS, lipid profile, Insulin-like growth factor 1 (IGF-1), the high-sensitivity C-reactive protein (hs-CRP), hemoglobin A1c (HbA1C), and glucose tolerance test (GTT) were measured following the intervention. Results Saffron petals reduced weight gain, Triglyceride (TG), and HbA1c and increased hs-CRP and IGF-1 (all p < 0.05). The damask rose petal reduced weight gain, FBS, hs-CRP, and HbA1c and increased the IGF-1 (all p < 0.05). Saffron plus damask-rose petals reduced the weight gain, TG, hs-CRP and HbA1c, and increase IGF-1 factor (all p < 0.05) compared to the control group. No significant effect was found on visceral fat, LDL-C, and HDL-C. Compared with the normal group, saffron petals and damask rose petals increased the FBS, HDL, and LDL levels. Damask rose and the combination of saffron petals and damask rose decreased IGF-1 compared with the normal group (all p < 0.05). Conclusions Saffron and damask rose petals could have beneficial effects on improving the status of biochemical markers. The simultaneous use of saffron and damask rose may counteract the adverse effects of saffron on inflammatory indices.
RADIOCARBON VS. LUMINESCENCE DATING OF ARCHAEOLOGICAL CERAMICS IN THE SOUTHERN ANDES: A REVIEW OF PAIRED DATES, BAYESIAN MODELS, AND A PILOT STUDY

ABSTRACT Archaeologists have been using luminescence to date pottery in South America since the late 1970s, inspired by early success in northern Chile. However, luminescence dates have not been rigorously compared to independent dating methods, which this paper’s goal. First, we present a compilation of 94 paired 14C and luminescence dates from the southern Andes, which reveals discrepancies across a range of contexts and ages. Second, we compare two Bayesian models of sets of 14C and thermoluminescence (TL) dates from three ceramic styles in the Azapa Valley, Chile, and the Inca occupation of Mendoza, Argentina. We find that only the 14C models produce results that agree with expectations based on independent data. Third, we present results from a pilot study in Mendoza that dated 6 sherds with 3 luminescence methods each and closely associated 14C dates. The reasons for disagreement between methods remain unclear, but Andean sediments with low and unstable luminescence sensitivity seem to be an important factor. Even though some luminescence ages are accurate, the clear trend of inconsistent results leads us to recommend that archaeologists use 14C rather than luminescence dates to build cultural chronologies.
HAZOR EB III CITY ABANDONMENT AND IBA PEOPLE RETURN: RADIOCARBON CHRONOLOGY AND ITS IMPLICATIONS

ABSTRACT Tel Hazor is one of only a few sites in Israel where remains of the Intermediate Bronze Age (IBA) in the second half of the 3rd millennium BC were found on top of Early Bronze III (EB III) city remains. A probe excavation was held at Hazor in 2017 to explore the chronological relation between the EB III and the IBA occupation. The radiocarbon (14C) absolute dates generated from this probe excavation show that following the EB III city demise, the site was abandoned for up to a few hundred years before it was resettled in the IBA. 14C dates obtained from the last level of the EB III city are well before 2500 BCE, fully aligned with the recent “High Chronology” for the EBA in the southern Levant. The excavation also produced dates associated with IBA “Black Wheel-Made Ware” vessels, which were found in large numbers at Hazor.