Miracle-dz/UniFAR-FTUs huggingface dataset:
Characterizing Mesoscale Eddies of Eastern Upwelling Origins in the Atlantic Ocean and Their Role in Offshore Transport

Motivated by the recurrent formation of eddies in the eastern upwelling areas, we examine cross-basin connectivity that is promoted by coherent, long-lived and long-propagating mesoscale eddies in the Atlantic Ocean. By applying the TOEddies detection and tracking algorithm to daily satellite observations (AVISO/DUACS) of Absolute Dynamic Topography (ADT), we characterize mesoscale eddy activity and variability in the North and South Atlantic. This method provides a robust eddy-network reconstruction, enabling the tracking of eddies formed in the Atlantic eastern upwelling systems together with any merging and splitting events they undergo during their lifetime as long as they remain detectable in the altimetry field. We show that during the years of observations, mesoscale eddies are long-lived coherent structures that can ensure oceanic connectivity between the eastern and the western boundaries, as a result of complex inter-eddy interactions. Moreover, alignment of South Atlantic eddies of eastern boundary origins with available Argo floats achieves a mean cross-basin connectivity signal from both anticyclonic and cyc5lonic eddies which is particularly evident at depth, along thermocline isopycnal layers of γn = 26 - 27 kg m–3. We explore two individual cyclonic eddy trajectories from in-situ measurements gathered by different Argo profiling floats trapped inside the eddy cores. Our results support the hypothesis that mesoscale eddies sustain and transport water masses while subducting during their westward propagation.
Application of Time Series Analysis to Estimate Drawdown From Multiple Well Fields

In 2018–2020, meteorological droughts over Northwestern Europe caused severe declines in groundwater heads with significant damage to groundwater-dependent ecosystems and agriculture. The response of the groundwater system to different hydrological stresses is valuable information for decision-makers. In this paper, a reproducible, data-driven approach using open-source software is proposed to quantify the effects of different hydrological stresses on heads. A scripted workflow was developed using the open-source Pastas software for time series modeling of heads. For each head time series, the best model structure and relevant hydrological stresses (rainfall, evaporation, river stages, and pumping at one or more well fields) were selected iteratively. A new method was applied to model multiple well fields with a single response function, where the response was scaled by the distances between the pumping and observation wells. Selection of the best model structure was performed through reliability checking based on four criteria. The time series model of each observation well represents an independent estimate of the contribution of different hydrological stresses to the head and is based exclusively on observed data. The approach was applied to estimate the drawdown caused by nearby well fields to 250 observed head time series measured at 122 locations in the eastern part of the Netherlands, a country where summer droughts can cause problems, even though the country is better known for problems with too much water. Reliable models were obtained for 126 head time series of which 78 contain one or more well fields as a contributing stress. The spatial variation of the modeled responses to pumping at the well fields show the expected decline with distance from the well field, even though all responses were modeled independently. An example application at one well field showed how the head response to pumping varies per aquifer. Time series analysis was used to determine the feasibility of reducing pumping rates to mitigate large drawdowns during droughts, which depends on the magnitude and response time of the groundwater system to changes in pumping. This is salient information for decision-makers. This article is part of the special issue “Rapid, Reproducible, and Robust Environmental Modeling for Decision Support: Worked Examples and Open-Source Software Tools”.
The Regulation and Modification of GSDMD Signaling in Diseases

Gasdermin D (GSDMD) serves as a key executor to trigger pyroptosis and is emerging as an attractive checkpoint in host defense, inflammatory, autoimmune diseases, and many other systemic diseases. Although canonical and non-canonical inflammasome-mediated classic GSDMD cleavage, GSDMD-NT migration to cell membrane, GSDMD-NT oligomerization, and pore forming have been well recognized, a few unique features of GSDMD in specific condition beyond its classic function, including non-lytic function of GSDMD, the modification and regulating mechanism of GSDMD signaling have also come to great attention and played a crucial role in biological processes and diseases. In the current review, we emphasized the GSDMD protein expression, stabilization, modification, activation, pore formation, and repair during pyroptosis, especially the regulation and modification of GSDMD signaling, such as GSDMD complex in polyubiquitination and non-pyroptosis release of IL-1β, ADP-riboxanation, NINJ1 in pore forming, GSDMD binding protein TRIM21, GSDMD succination, and Regulator-Rag-mTOR-ROS regulation of GSDMD. We also discussed the novel therapeutic strategies of targeting GSDMD and summarized recently identified inhibitors with great prospect.
Construction of a Model of Nurse Engagement in Long-Term Care Facilities: A Moderated-Mediation Model

Aim The aim of the study is to test a moderated mediation model that focuses on job resources mediating the relationship between organizational climate and nurse engagement in the long-term care facilities and emotional intelligence moderates this mediated relationship. Background The shortage of nurses is a global problem, especially in the long-term care facilities. We integrated and extended past research exploring the influence of nurse engagement and constructed a model of nurse engagement in the long-term care facilities. Method A cross-sectional survey was conducted on 494 nurses in long-term care facilities. Nurses were asked to complete a survey of nurse engagement, organizational climate, job resources, and emotional intelligence. Results The consequence demonstrated that organizational climate increased nurse engagement directly and indirectly via job resources. In addition, emotional intelligence plays a moderation role between organizational climate and job resources. Conclusion These phenomena revealed that a good organizational climate and job resources enable nurses to be more engaged in work. Nurse with high-emotional intelligence can take advantage of resources and improve their engagement.
Melatonin Rhythm and Its Relation to Sleep and Circadian Parameters in Children and Adolescents With Autism Spectrum Disorder

Introduction Sleep problems are prevalent among individuals with autism spectrum disorder (ASD), and a role has been attributed to melatonin in this multifactorial comorbidity. Methods A cross-sectional study was conducted on 41 autistic children and adolescents (9.9 ± 3.02) and 24 children and adolescents with a normal intellectual function (8.42 ± 2.43) were used as controls. Subjects were matched for sex, body mass index, and pubertal stage, and all were drug-naive. Circadian and sleep parameters were studied using an ambulatory circadian monitoring (ACM) device, and saliva samples were collected around the onset of sleep to determine dim light melatonin onset (DLMO). Results Prepubertal individuals with ASD presented later DLMO and an earlier decline in melatonin during adolescence. A relationship was found between melatonin and both sleep and circadian parameters. Participants and controls with later DLMOs were more likely to have delayed sleep onset times. In the ASD group, subjects with the later daytime midpoint of temperature had a later DLMO. Later melatonin peak time and DLMO time were related to lower general motor activity and lower stability of its rhythms. Conclusion The melatonin secretion pattern was different in individuals with ASD, and it showed a relationship with sleep and circadian parameters. Alterations in DLMO have not been previously reported in ASD with the exception of more variable DLMO timing; however, high variability in the study design and sample characteristics prevents direct comparison. The ACM device enabled the measurement of circadian rhythm, a scarcely described parameter in autistic children. When studied in combination with other measures such as melatonin, ACM can offer further knowledge on sleep problems in ASD.
Association Between Sleep Duration and Parkinson’s Disease Varied Across Related Orphan Receptor A rs2028122 Genotypes

Background The purpose of the study was to examine the association of long and short sleep duration with risk of Parkinson’s disease (PD) across RORA rs2028122 genotypes. Methods In the present prospective study with a large sized UK Biobank cohort, we performed multivariate logistic regression analyses, generalized additive model, interaction terms, stratification analysis, and mediation analysis to evaluate the association of long and short sleep duration with risk of PD across RORA rs2028122 genotypes. Results The GG genotype [1.16 (1.01, 1.33)], a short sleep duration [1.23 (1.10, 1.37)], and a long sleep duration [1.19 (1.03, 1.37)] were identified as the independent risk factors for PD. Sleep duration exhibited a curvilinear U-shaped correlation with the risk of PD; first, the risk of PD gradually decreased as the length of sleep increase, but then, the risk began to increase as the length of sleep increase. Among habitual long sleepers, AG carriers had a higher risk of PD compared with AA carriers [1.67 (1.09, 2.55)]. Among AG carriers, both habitual short [1.28 (1.09, 1.50)] and long [1.38 (1.13, 1.69)] sleepers increased the risk of PD compared with habitual normal sleepers. Among GG carriers, habitual short sleepers have a higher risk of PD [1.26 (1.06, 1.50)] compared with habitual normal sleepers. A mediation model suggested that the rs2028122 genotype partially mediated the causal pathway of sleep duration leading to the development of PD on a positive effect. Conclusion Our study demonstrated that the association between sleep duration and PD risk varied across different RORA rs2028122 genotypes. Our findings could help individuals to identify their potential risk profile and take timely actions to prevent the PD.
32Pi Labeled Transgenic Wheat Shows the Accumulation of Phosphatidylinositol 4,5-bisphosphate and Phosphatidic Acid Under Heat and Osmotic Stress

The ensuing heat stress drastically affects wheat plant growth and development, consequently compromising its grain yield. There are many thermoregulatory processes/mechanisms mediated by ion channels, lipids, and lipid-modifying enzymes that occur in the plasma membrane and the chloroplast. With the onset of abiotic or biotic stresses, phosphoinositide-specific phospholipase C (PI-PLC), as a signaling enzyme, hydrolyzes phosphatidylinositol 4,5-bisphosphate (PIP2) to generate inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) which is further phosphorylated into phosphatidic acid (PA) as a secondary messenger and is involved in multiple processes. In the current study, a phospholipase C (PLC) signaling pathway was investigated in spring wheat (Triticum aestivum L.) and evaluated its four AtPLC5 overexpressed (OE)/transgenic lines under heat and osmotic stresses through 32Pi radioactive labeling. Naturally, the wheat harbors only a small amount of PIP2. However, with the sudden increase in temperature (40°C), PIP2 levels start to rise within 7.5 min in a time-dependent manner in wild-type (Wt) wheat. While the Phosphatidic acid (PA) level also elevated up to 1.6-fold upon exposing wild-type wheat to heat stress (40°C). However, at the anthesis stage, a significant increase of ∼4.5-folds in PIP2 level was observed within 30 min at 40°C in AtPLC5 over-expressed wheat lines. Significant differences in PIP2 level were observed in Wt and AtPLC5-OE lines when treated with 1200 mM sorbitol solution. It is assumed that the phenomenon might be a result of the activation of PLC/DGK pathways. Together, these results indicate that heat stress and osmotic stress activate several lipid responses in wild-type and transgenic wheat and can explain heat and osmotic stress tolerance in the wheat plant.
Editorial: Innate Immune System Guiding Physiological Plasticity in Invertebrates

Innate immunity mechanisms have provided an effective means of surveillance and protection against parasites and pathogens in invertebrates. With the lack of adaptive immunity, invertebrates rely on the plasticity conferred by innate immunity to eliminate pathogens, and perhaps more importantly discriminating them from other microorganisms. Moreover, credible evidences from studies in infection immunity, transplantation immunity, individual, and transgenerational immune priming have highlighted the development of immunological memory, a characteristic feature of adaptive immunity, under the innate immune response specialty of invertebrates. This Research Topic gathers different contributions highlighting the phenotypic plasticity in terms of innate immunity traits underlying the physiological status of invertebrates. These contributions expand our understanding of the novel components of innate immunity signaling cascades, elucidation of physiological fitness traits and pathogen evasion mechanisms intricately attributed to invertebrate survival. The mealworm beetle, Tenebrio molitor has provided rich insights to unravel the mysteries of innate immune mechanisms in invertebrates pertinent to host-pathogen interactions. In the last decade or so, many critical components of Toll, Imd, Jak-Stat, and autophagy signaling cascades have been deciphered in the beetle model using elegant biochemical, genetic, and genomics approaches. These studies have collectively highlighted antimicrobial innate immune responses in T. molitor while characterizing the conserved pathway components regarding antimicrobial peptide (AMP) production. The first article of this Research Topic (Bae et al.) discusses the anti-Gram-negative function of another Toll ligand spätzle 1b (TmSpz1b) identified from the RNA sequencing database of T. molitor. Other studies, reported by the same research group, have critically characterized the function of T. molitor spätzle isoforms such as spätzle 5 (TmSpz5) and spätzle 6 (TmSpz6) in regulating AMP production in the Malpighian tubules in response to Escherichia coli, and against E. coli and Staphylococcus aureus, respectively (Edosa et al., 2020; AliMohammadie Kojour et al., 2021). TmSpz1bwas characterized as a secretory protein with a conserved cystine-knot domain as evidenced in other insects including spätzle protein in Drosophila melanogaster. Further, the authors reported the requirement of TmSpz1b in regulation of AMP genes in hemocytes and fat bodies and showing susceptible phenotype against E. coli infection. The inclusion of TmSpz1b in regulating Toll pathway was suggested as TmSpz1b silenced individuals showed downregulation of TmDorsal (a critical NF-kB factor regulating Toll cascade mechanisms) transcripts. In the second article, Ko et al. functionally characterized the inhibitor of nuclear factor kappa B kinase epsilon isoform from T. molitor (TmIKKε), that is a transcriptional regulator of Imd pathway and Janus kinase (JNK) activation Edited and reviewed by: Klaus H. Hoffmann, University of Bayreuth, Germany
The Welfare of Nile Tilapia (Oreochromis niloticus, GIFT Strain) Juveniles Cultured in Different Light Spectra

The light spectrum is a vital environmental factor for the culture of fish, and the welfare of farmed fish is a crucial issue in aquaculture. In this study, Nile tilapia (Oreochromis niloticus, GIFT strain) juveniles were exposed to full-spectrum (LW), red (LR), yellow (LY), or blue (LB) light. After the 45-day experiment, growth performance, stress responses, and aggressive behaviors were evaluated, and transcriptomic analysis was carried out. The results revealed that LW and LR positively affected growth performance. At the same time, LY and LB had a negative effect. Light spectrum induced stress responses of juvenile fish exposed to LY, under which the total antioxidant capacity (T-AOC) and cortisol (COR) contents were the highest. The activities of α-amylase (AMS), protease (PES), and lipase (LPS) in the digestive tract showed a similar tendency, indicating that the light spectra altered the digestive enzyme activities and then affected growth. Behavioral analyses showed increased chase and bite activities of tilapia juveniles exposed to LW and LY. The affected functions included the nervous system, muscle morphogenesis, and immune system-related regulation. Enriched Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways include the tryptophan metabolism signaling pathway, protein digestion and absorption signaling pathway, Jak-STAT signaling pathway, arachidonic acid metabolism signaling pathway, and alpha-linolenic acid metabolism signaling pathway. Overall, light spectra influenced the welfare of farmed tilapia juveniles in terms of growth, stress, and behavior. Our results suggested that LR should be used in juvenile tilapia culture.
Pilot Study on Feasibility of Sensory-Enhanced Rehabilitation in Canine Spinal Cord Injury

Physical rehabilitation is frequently recommended in dogs recovering from acute thoracolumbar intervertebral disc extrusion (TL-IVDE), but protocols vary widely. The objective of this study was to evaluate the feasibility of incorporating sensory-integrated neurorehabilitation strategies into a post-operative rehabilitation protocol in dogs with TL-IVDE. Non-ambulatory dogs with acute TL-IVDE managed surgically were prospectively recruited to this unblinded cross-over feasibility study. Eligible dogs were randomized to start with tactile-enhanced (artificial grass) or auditory-enhanced (floor piano) basic rehabilitation exercises performed twice daily for the first 4 weeks before switching to the opposite surface for the subsequent 4 weeks. Neurologic examination, open field gait scoring, girth measurements and an owner-completed feasibility questionnaire were performed at baseline and 2, 4, 6, and 8 weeks post-operatively. Twenty-four dogs were enrolled, 12 randomized to each order of exercises. Gait scores did not differ between the two groups at baseline, 4 or 8 week visits. All modified exercises could be performed and compliance was high. Adverse events potentially attributable to the study surface were mild, self-limiting and occurred in 2/24 dogs. The most common surface-related limitations were that the piano was slippery and that both surfaces were too short. The artificial grass was preferred by owners and dogs compared to the floor piano surface, but this was influenced by which surface was utilized first. Auditory and tactile modifications were feasible and safe to incorporate into a standardized rehabilitation protocol. This pilot study could prompt larger efficacy studies investigating the benefit of sensory-integrated rehabilitation in dogs with TL-IVDE.
Characteristics and Trends in Unethical Pro-organizational Behavior Research in Business and Management: A Bibliometric Analysis

Unethical pro-organizational behavior is one of the core factors that affect organizational development. Although enterprises and researchers have done a lot of work, a quantitative and systematic assessment of unethical pro-organizational behavior research is still lacking, this review conducts a bibliometric analysis to describe the characteristics and trends of unethical pro-organizational behavior research in business and management, such as publication trend analysis, co-citation analysis, keywords co-occurrence analysis, and citation burst analysis. The results show that 89 articles and 4,523 references from 49 journals contributed by 254 authors are identified. The number of publications has increased significantly since 2019. The China and United States are the most productive country. Umphress E and Yam C are the most influential authors. “Journal of Business Ethics and Frontiers in Psychology” are the most influential journal, 26 words in 516 keywords constitute the strongest set of terms available, Keyword co-occurrence analysis found ethical decision-making, the measurement, and impact of unethical pro-organizational behavior, the antecedents of ethical leadership are worthy and prospective potential trends. These findings provide a systematically, transparently, and visually reviewed the landscape and development process of unethical pro-organizational behavior research, which may help researchers and practitioners to understand unethical pro-organizational behavior in business management and provide a new perspective for future research.
Self-Stigma Among People With Mental Health Problems in Terms of Warmth and Competence

Introduction Self-stigma arising from public stigma is a heavy burden for people suffering from mental health problems. Both public stigma and self-stigma encompass the same three elements: stereotype, prejudice, and discrimination. Public stigma has already been successfully explored by the Stereotype Content Model (SCM) and the Behaviors from Intergroup Affect and Stereotypes (BIAS) map. However, this is not the case for self-stigma. Therefore, this is the first study that applies SCM and the BIAS map to self-stigma by examining whether the effects of self-stereotypes on self-directed discrimination would be mediated by self-directed prejudices in people with mental health problems. Method Within a total sample of N = 823 participants, who took part in an online survey, n = 336 people reported mental health problems. Mental health and self-stereotypes (warmth, competence), self-directed prejudice (negative emotions), and self-directed discrimination (active/passive self-harm) were assessed. Results Structural equation modeling supported the hypothesis that the stereotype dimensions warmth and competence negatively related to prejudice, while stronger prejudice was associated with more discrimination (active/passive self-harm). Prejudice fully mediated the relationship between stereotypes and discrimination. The indirect effects of warmth and competence on active and passive self-harm were moderated by competence and warmth. Discussion Implications for further research on self-stigma and the usage of SCM and BIAS map are discussed.