Miracle-dz/UniFAR-FTUs huggingface dataset:
Gene Expression Risk Scores for COVID-19 Illness Severity

Abstract Background The correlates of coronavirus disease 2019 (COVID-19) illness severity following infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are incompletely understood. Methods We assessed peripheral blood gene expression in 53 adults with confirmed SARS-CoV-2 infection clinically adjudicated as having mild, moderate, or severe disease. Supervised principal components analysis was used to build a weighted gene expression risk score (WGERS) to discriminate between severe and nonsevere COVID-19. Results Gene expression patterns in participants with mild and moderate illness were similar, but significantly different from severe illness. When comparing severe versus nonsevere illness, we identified >4000 genes differentially expressed (false discovery rate < 0.05). Biological pathways increased in severe COVID-19 were associated with platelet activation and coagulation, and those significantly decreased with T-cell signaling and differentiation. A WGERS based on 18 genes distinguished severe illness in our training cohort (cross-validated receiver operating characteristic-area under the curve [ROC-AUC] = 0.98), and need for intensive care in an independent cohort (ROC-AUC = 0.85). Dichotomizing the WGERS yielded 100% sensitivity and 85% specificity for classifying severe illness in our training cohort, and 84% sensitivity and 74% specificity for defining the need for intensive care in the validation cohort. Conclusions These data suggest that gene expression classifiers may provide clinical utility as predictors of COVID-19 illness severity.
Entrepreneurs and China’s private sector SMEs’ performance

ABSTRACT The Chinese government adopted the ‘Mass Entrepreneurship and Innovation’ (MEI) strategy in 2015 to increase the number of entrepreneurs, the number of private small-medium enterprises (SMEs) and firm innovation. Using China’s firm-level data, we find that different entrepreneurial factors such as startup motivation, personal characteristics (age, gender), human capital (education, experience) and guanxi (political and business connections) impact the technical efficiency scores of SMEs in Eastern and non-Eastern regions differently. Our results also show that regional economic development and entrepreneurial quality disparities in China’s economy warrant entrepreneurial policies tailored to address these differences if they are to be effective in improving the technical efficiency performance of firms. Based on our findings, one may argue that the MEI strategy will not be adequate by simply focusing upon increasing the number of entrepreneurs without considering regional differences in development and entrepreneur characteristics.
Acidic and Hypoxic Microenvironment in Melanoma: Impact of Tumour Exosomes on Disease Progression

The mechanisms of melanoma progression have been extensively studied in the last decade, and despite the diagnostic and therapeutic advancements pursued, malignant melanoma still accounts for 60% of skin cancer deaths. Therefore, research efforts are required to better define the intercellular molecular steps underlying the melanoma development. In an attempt to represent the complexity of the tumour microenvironment (TME), here we analysed the studies on melanoma in acidic and hypoxic microenvironments and the interactions with stromal and immune cells. Within TME, acidity and hypoxia force melanoma cells to adapt and to evolve into a malignant phenotype, through the cooperation of the tumour-surrounding stromal cells and the escape from the immune surveillance. The role of tumour exosomes in the intercellular crosstalk has been generally addressed, but less studied in acidic and hypoxic conditions. Thus, this review aims to summarize the role of acidic and hypoxic microenvironment in melanoma biology, as well as the role played by melanoma-derived exosomes (Mexo) under these conditions. We also present a perspective on the characteristics of acidic and hypoxic exosomes to disclose molecules, to be further considered as promising biomarkers for an early detection of the disease. An update on the use of exosomes in melanoma diagnosis, prognosis and response to treatment will be also provided and discussed.
Parental Pesticide Exposure and Childhood Brain Cancer: A Systematic Review and Meta-Analysis Confirming the IARC/WHO Monographs on Some Organophosphate Insecticides and Herbicides

Background: Brain tumors are the second most common neoplasm in the pediatric age. Pesticides may play an etiologic role, but literature results are conflicting. This review provides a systematic overview, meta-analysis, and IARC/WHO consideration of data on parental exposure to pesticides and childhood brain tumors. Methods: We searched PubMed, SCOPUS, and Google Scholar for literature (1 January 1966–31 December 2020) that assessed childhood brain tumors and parental exposure to pesticides. We undertook a meta-analysis addressing prenatal exposure, exposure after birth, occupational exposure, and residential exposure. A total of 130 case-control investigations involving 43,598 individuals (18,198 cases and 25,400 controls) were included. Results: Prenatal exposure is associated with childhood brain tumors (odds ratio, OR = 1.32; 95% CI: 1.17–1.49; I2 = 41.1%). The same occurs after birth exposure (OR = 1.22; 95% CI: 1.03–1.45, I2 = 72.3%) and residential exposure to pesticides (OR = 1.31; 95% CI: 1.11–1.54, I2 = 67.2%). Parental occupational exposure is only marginally associated with CBT (OR = 1.17, 95% CI: 0.99–1.38, I2 = 67.0%). Conclusions: There is an association between CBT and parental pesticides exposure before childbirth, after birth, and residential exposure. It is in line with the IARC Monograph evaluating the carcinogenicity of diazinon, glyphosate, malathion, parathion, and tetrachlorvinphos.
Structural and theoretical investigations, Hirshfeld surface analysis and anti-SARS CoV-2 of nickel (II) coordination complex

Abstract A nickel(II) Schiff base complex, [Ni(L)(DMF)](1), was synthesized by treating NiCl2.6H2O with an ONS-donor Schiff base ligand(H2L) derived from the condensation 3,5-Dichlorosalicylaldehyde and 4,4-Dimethyl-3-thiosemicarbazide in DMF. The geometry around the center metal ion in [Ni(L)(DMF)](1) was square planar as revealed by the data collection from diffraction studies. DFT calculations were performed on the complex to get a structure-property relationship. Hirshfeld surface analysis was also carried out in the crystal structure of nickel (II) Schiff base complex. Additionally, inspiring from recent developments to find a potential inhibitor for SARS-CoV-2 virus, we have also performed molecular docking study of [Ni(L)(DMF)](1) to see if our novel complex show affinity for main protease (Mpro) of SARS-CoV-2 Mpro (PDB ID: 6LZE). Interestingly, the results are found quite encouraging where the binding affinity and inhibition constant was found to be −6.6 kcal/mol and 2.358 µM, respectively, for the best docked confirmation of complex [Ni(L)(DMF)](1) with Mpro protein. This binding affinity is reasonably well as compared to recently known antiviral drugs. For instance, the binding affinity of complex [Ni(L)(DMF)](1) is found to be better than that of recently docking results of anti-SARS-CoV-2 drugs like chloroquine (-6.293 kcal/mol), hydroxychloroquine (-5.573 kcal/mol) and remdesivir (-6.352 kcal/mol) when targeted to the active-site of SARS-CoV-2 Mpro. Besides this, molecular docking against G25K GTP-nucleotide binding protein (PDB ID: 1A4R) was also studied. We believe that current results can intrigue not only for the biomedical community but also for the materials chemists who are engaged to explore the application coordination complexes. Communicated by Ramaswamy H. Sarma
Evaluation of the Practicability of Biosynex Antigen Self-Test COVID-19 AG+ for the Detection of SARS-CoV-2 Nucleocapsid Protein from Self-Collected Nasal Mid-Turbinate Secretions in the General Public in France

Due to their ease-of-use, lateral flow assay SARS-CoV-2 antigen-detecting rapid diagnostic tests could be suitable candidates for antigen-detecting rapid diagnostic self-test (Ag-RDST). We evaluated the practicability of the Ag-RDST BIOSYNEX Antigen Self-Test COVID-19 Ag+ (Biosynex Swiss SA, Freiburg, Switzerland), using self-collected nasal secretions from the turbinate medium (NMT), in 106 prospectively included adult volunteers living in Paris, France. The majority of the participants correctly understood the instructions for use (94.4%; 95% confidence interval (CI): 88.3–97.4), showing a great ability to perform the entire self-test procedure to obtain a valid and interpretable result (100%; 95% CI: 96.5–100), and demonstrated the ability to correctly interpret test results (96.2%; 95% CI: 94.2–97.5) with a high level of general satisfaction. About one in eight participants (# 15%) needed verbal help to perform or interpret the test, and only 3.8% of test results were misinterpreted. By reference to multiplex real-time RT-PCR, the Ag-RDST showed 90.9% and 100% sensitivity and specificity, respectively, and high agreement (98.1%), reliability (0.94), and accuracy (90.9%) to detect SARS-CoV-2 antigen. Taken together, our study demonstrates the high usability and accuracy of BIOSYNEX Antigen Self-Test COVID-19 Ag+ for supervised self-collected NMT sampling in an unselected adult population living in France.
International enterprise education in Sri Lanka: a blended approach

Purpose – The purpose of this paper is to explore how enterprise education was adapted from a UK higher education institution (HEI) setting into an international context through collaboration with two Sri Lankan universities. It demonstrates the value of enterprise education in different cultures, and presents learning from the challenges faced by both staff and students in moving away from a traditional delivery method.Design/methodology/approach – Adopting a case study approach, the paper describes a blended, incremental implementation strategy aimed at developing staff and students’ understanding of enterprise education in a gradual, supportive and culturally‐sensitive manner. Evaluation is conducted through an analysis of formal assessment performance and qualitative module review.Findings – The paper demonstrates the impact of enterprise education in an international context and a capability amongst most students to engage with it successfully, whilst also highlighting the challenges of delivery in a.
Assessment of Implicit Interests through an Unobtrusive Computer Task. Their Relations with Career Decision, Anxiety, and Personality Traits

Adolescence is a period where youngsters still do not know much about themselves. That makes some decisions, like those concerning vocational elections, a complicated issue that has important consequences for their life. The main goal of this piece of research is to measure implicit interests using a situated, unobtrusive computer tool (PrUnAs: Preferences Unobtrusive Assessment) as well as its connection with anxiety and personality traits: neuroticism, extraversion, self-efficacy, optimism, consciousness, and openness. Sample: 304 16-year-old adolescents enrolled in the last course of compulsory education. Instruments: Computer programs were used to measure implicit interests, career preferences, and to self-descript personality traits; finally, the paper-and-pencil test Stai was applied to measure anxiety. Results: Concordance between implicit interests and explicit choices was less than 50%. The software developed for assessing implicit interests not only proved to be an efficient tool to make them arise but also a good predictor of anxiety. Conclusions: Implicit interests and explicit elections are not the same. The approach from implicit preferences is an important shift in the approximation to vocational guiding and to reduce youngsters’ indecision level. Beyond vocational choice, this information may improve the short- and long-term quality of life and mental health.
Operation of electromagnetic reverberation chambers with wave diffractors at relatively low frequencies

The dependence of the modal density on chamber geometry is analyzed, for general unstirred reverberation chambers at relatively low frequencies of operation. An expression for the lowest usable frequency is derived based on the chamber mode density. The use of curved wave diffractors is investigated as a method for increasing the average mode density. The specific effect of corner, edge, surface and volume diffractors on the mode density and quality factor of a nominally rectangular shielded room is analyzed as a function of diffractor size, density, and operating frequency. This paper complements earlier studies on field statistics of undermoded reverberation chambers and the performance of acoustic-type diffusers in electromagnetic reverberation chambers.
Substrate crosstalk reduction using SOI technology

This work analyzes both by simulations and measurements the substrate crosstalk performances of various Silicon-On-Insulator (SOI) technologies, and compares them to those of normal bulk CMOS process. The influence of various parameters, such as substrate resistivity, buried oxide thickness and distance between devices, is investigated. The use of capacitive guard rings is proposed, and their effectiveness is demonstrated. A simple RC model has been developed to allow a deep understanding of these phenomena as well as to simplify future studies of more complex systems. The superiority of high-resistivity SIMOX substrates over standard SOI and bulk is finally demonstrated.
Surface Modification Using Electric Discharge Machining (EDM) with Powder Addition

Powder mixed electrical discharge machining (PMEDM) is one of the recent innovations for the enhancement of the capabilities of EDM process. In this study, the effects of powder addition on the surface modification of mild steel were investigated. Copper tungsten electrode was used in the machining. Two different powders namely TiC and Al2O3 were used in the study with kerosene as the dielectric medium. The powder types and currents were manipulated to study their effects on the machined surface. The results show that increasing the current leads to increase in recast layer thickness, and the cracks. The Al2O3 powder gave higher layer thickness than TiC powder. TiC Powder addition also produced higher hardness, more tool material and carbon depositions on the work surface than Al2O3 powder.
Unconstrained approach for isolating individual trees using high-resolution aerial imagery

This study outlines an algorithm that can be used for individual tree detection and crown delineation; it was applied to coniferous forest using aerial imagery. This article explains the assumptions and processes involved in the algorithm, presents the results of the applications, and discusses possible limitations. The algorithm, which adopts contextual analysis that excludes the need to specify window size, was applied to detect and delineate individual trees based on morphological and reflective characteristics. The preprocessing steps included suppression of the non-coniferous area (i.e. non-forest and leaf-off deciduous forest) and the creation of appropriately smoothed imagery using an optimal smoothing level based on accuracy index (AI); thereafter, unconstrained directional peak- and edge-finding algorithms were processed separately. To assess the tree detection and crown delineation processes, the results of the algorithms were evaluated carefully against visually interpreted crowns in six square plots using several statistical measures based on tree top correspondence, positional difference of tree top, directional crown width, and crown area assessment. The average tree top correspondence had an AI of 88.83%. The positional difference between detected and visually interpreted tree tops was measured and its average was 0.6 m. For our 0.5 m/pixel aerial imagery, the average root mean square error (RMSE) of crown width in six sample plots was found to be 2.8 m, and crown area estimation resulted in RMSE of approximately 9.23 m2 (23.25%). In general, this study highlights the potentiality of the proposed algorithm to efficiently and automatically acquire forest information such as tree numbers, crown width, and crown area.
Support of the Implementation of a Whistleblowing System for Smoke-Free Environments: A Mixed Methods Approach

Enforcement of a smoke-free policy is of vital concern in support of the health of smokers and bystanders. Indonesia has issued a smoke-free law, but implementation and enforcement lie with the regional and municipal governments. In a survey of 225 respondents recruited via schools, knowledge about the health effects of smoking and the smoke-free regulation, as well as attitudes towards and commitment and support of the enforcement of the smoke-free regulation in the Kendari City through an electronic whistleblowing system was examined. Furthermore, the participants were asked about the smoking status and smoking behavior. About half of the respondents were students (teenagers), the other half—their parents. Male respondents were strongly overrepresented (85%). Only 18% of the respondents declared to be smokers, mostly adults and males. Both the smokers and the non-smokers supported the smoke-free law and its enforcement through a whistleblowing system. Representatives of the local government were interviewed and participated in focus group discussions. In general, they also exhibited strong support of an electronic enforcement tool. However, issues of efficiency, costs, and responsibility must still be resolved. Nevertheless, an electronic whistleblowing system has the potential to further the health and livelihoods in a community like the Kendari City.
Health Literacy, Socio-Economic Determinants, and Healthy Behaviours: Results from a Large Representative Sample of Tuscany Region, Italy

Background: Health Literacy (HL) is one of the main determinants of health and is crucial for the prevention of noncommunicable diseases, by influencing key health-related behaviours. The aim of the present study was to assess the role of HL and sociodemographic factors in predicting the adoption of two healthy behaviours—physical activity and fruits and vegetables consumption. Methods: This study was conducted on the Tuscan population subsample of the Italian Behavioral Risk Factor Surveillance System in 2017–2018. HL was assessed using the Italian version of the six-item European Health Literacy Survey Questionnaire (HLS-EU-Q6). Results: About 40% of the 7157 interviewees reported an inadequate or problematic HL level. Female sex, poor financial status, foreign nationality, and low education were associated with a problematic HL level, while an inadequate HL level was associated with being 50–69 years old, low education level, foreign nationality, poor financial status and unemployment or inactive status. Inadequate HL level was a strong predictor of both eating less than three portions of fruits/vegetables per day and not engaging in sufficient PA during leisure times. Conclusions: Our findings showed that an inadequate level of HL could negatively affect physical activity and diet, independently from the other sociodemographic conditions, confirming the role of HL as a relevant social determinant of health.
The future of remote work in Japan: Covid-19’s implications for international human resource management

Objective: The objective of this article is to elaborate how the form of remote work can be hindered in an institutional cultural context in non-Western countries. Research Design & Methods: The article adopts data collection based on public report and news release in reference to the current academic literature of human resource management. Findings: The article finds that the institutional contexts of non-Western countries, unlike those of Western countries, may hinder or limit remote work because of a poor fit between remote work and human resource management (HRM). The article reveals that the cultural context of non-Western countries, such as Japan, may hinder remote work because of collectivism, high context, high power distance, and high uncertainty avoidance. Implications & Recommendations: The article implicates a possible diversity of how remote work can be implemented in relation to the institutional and cultural contexts of both Western and non-Western countries, such as Japan. Contribution & Value Added: The article contributes to future international human resource management by showing that there are some institutional and cultural hindrances to remote work in certain countries. The text contributes to future international business and human resource management by showing that other non-Western countries may have similar problems in terms of the execution of remote work due to contexts that are different institutional and cultural from Western examples.
The role of transactive memory systems, psychological safety and interpersonal conflict in hospital team performance

Abstract Safe patient care in hospitals relies on teamwork. Transactive Memory Systems (TMS), are shared cognitive systems that have been linked to team performance in other domains, but have received limited attention in healthcare. This study investigated the role of TMS, psychological safety and interpersonal conflict in predicting team performance in hospital ward teams where team membership is dynamic and often loosely defined. Hospital staff (n = 106) in four wards completed a battery of instruments assessing team performance, TMS, psychological safety and interpersonal conflict. TMS was a weak predictor of team performance, but the relationship was mediated by psychological safety. Overall, team performance was predicted by high psychological safety, low interpersonal conflict and low reliance on team members’ knowledge (i.e. TMS credibility). These findings suggest that, in hospital teams, TMS is not a strong predictor of team performance but team culture is critical to ensure the quality and safety of patient care. Practitioner summary: This study investigated the role of Transactive Memory Systems (TMS) and cultural factors in hospital team performance. Team performance was predicted by psychological safety, low interpersonal conflict and low reliance on team members’ untested knowledge. This highlights the importance of a supportive and psychologically safe team culture for safe care in hospitals. Abbreviations: TMS: transactive memory systems; HCA: health care assistant