Miracle-dz/UniFAR-FTUs huggingface dataset:
Visual Recovery After Decompression Surgery of Skull Base Meningioma: A Case Report

The patient is a 39-year-old female who was referred to neuroophthalmology office on November 2018 for the optic atrophy of left eye. She had noticed vision less in the left eye when she went to DMV for renewal of her license. She was not aware of the duration of vision loss. There was no history of pain with eye movement, trauma to the eye, infectious, and or inflammatory disease. She denied headaches, diplopia, numbness or tingling, and low back pain. Her past medical and surgery history was not significant. In eye exam, her vision was 20/25 on right and 20/150 left eye. Color vision was 11/11 in right and 1/11 in left eye. She had RAPD in left eye. Visual field of the right eye was normal. She was not able to do visual field on the left side. OCT optic nerve showed mild RNFL thinning on the left eye. MRI brain and orbit showed an enhancing mass impressing on the posterior aspect of the left optic nerve showing a slight dural tail measuring 13.1x11. 1x12.2 mm, consistent with meningioma. The mass encases left internal artery. She was referred to neurosurgeon for tumor resection. She gained back some of her vision immediately after surgery. The patient came back for follow up on December 2018. Her vision was 20/20 in both eyes and color vision on left eye was improved to 5/11 (Figure 1,2).
Common barriers to healthcare for transgender people in the U.S. Southeast.

Background: Transgender and non-binary people are more likely to face barriers to healthcare than their cisgender counterparts. The majority of work in this area centers on the experiences of transgender people in northern cities and urban enclaves, yet over 500,000 transgender people live in the U.S. Southeast. Aims: The purpose of this study is to explore barriers to healthcare among transgender people in the U.S. Southeast. Methods: The research team conducted four 120-minute focus groups (eligibility criteria: 18 years or older, self-identify as transgender, live in the U.S. Southeast). Participants completed a demographic questionnaire prior to the start of the focus group. Each focus group explored access to and experiences of receiving basic healthcare as a transgender person in the U.S. Southeast. Established qualitative methods were used to conduct the focus groups and data analysis. Results: Participants (n = 48) ranged in age from 19 to 65, with the majority identifying as trans women (43.8%) and non-binary (33.3%). The sample was racially diverse: White (50%), Black (37.5%), and Latinx or Multiracial (12.5%). Multiple barriers to care were identified: (1) fear and mistrust of providers; (2) inconsistency in access to healthcare; (3) disrespect from providers; and, (4) mistreatment due to intersecting experiences of gender, race, class, and location. Discussion: Transgender Southerners face barriers to care at the structural, cultural, and interpersonal levels. The study results have implications for researchers, as well as providers, practices, and health care systems throughout the region.
Beyond Spiritual Focus: Climate Change Awareness, Role Perception, and Action among Church Leaders in Nigeria

This study explored the role of church leaders in addressing climate change with a focus on Catholic, Anglican, and Pentecostal churches in Nigeria. The study adopted a semistructured face-to-face interview with 30 church leaders drawn from the selected denominations (i.e., 10 church leaders from each denomination). These participants were spread across five states in five geopolitical zones in Nigeria. A descriptive narrative approach was employed in the thematic organization and analysis of data. Findings showed that while all the participants across the three denominations—Catholic, Anglican, and Pentecostal churches—agreed to have heard of climate change, their perceptions of the causes of the phenomenon were narrow and varied along religious denominational lines. More Catholic participants expressed belief in anthropogenic climate change than did Anglicans and Pentecostals. Awareness creation, charity for disaster victims, and prayer were identified by the participants as the roles churches can play in addressing climate change. Although climate change action was generally poor among participants, Catholics engaged more in organizational action than did Anglicans and Pentecostals. In contrast, climate change actions were more on a personal level than on the organizational/church level within Pentecostal churches. The implications of the findings for the Church/church leaders, policy, and future research are discussed.
The prognostic value of metabolic tumor volume in FDG PET/CT evaluation of post-operative survival in patients with esophageal squamous cell cancer

Objective To evaluate the prognostic value of MTV on 18F-FDG PET/CT in patients with esophageal cancer.Methods Forty-nine patients with esophageal cancer underwent 18 F-FDG PET/CT scan before surgery.The median follow-up time for the patients was 29 months (range,8- 57 months). The prognostic significance of MTV,age,sex,histologic grade,SUVmax of the primary tumor,tumor size measured on PET/CT,T stage,N stage,M stage,American Joint Committee on Cancer (AJCC) stage,number and location of lymph nodes metastases were assessed by Kaplan-Meier analysis and multivariate Cox model.Results In the univariate analysis,AJCC stage (x2 =16.206,hazard ratio (HR) =1.177,P ＜0.001),N stage (x2 =9.536,HR =10.833,P =0.002),T stage (x2 =5.810,HR=2.397,P=0.016),number of lymph nodes metastases (x2 =11.423,HR =1.567,P =0.001 ),and MTV (x2 =3.872,HR =2.433,P =0.049 ) were significant predictors of survival.Multivariate analysis showed that MTV and AJCC stage were independent predictors of survival (x2 =4.525,HR 1.170,P =0.033 ; X2=4.875,HR =3.071,P =0.027). Kaplan-Meier survival curves revealed longer survival time of low-MTV group as compared to high-MTV group ( Log-rank,x2 =4.186,P =0.041 ). Conclusion MTV on 18 F-FDG PET/CT may be an independent prognostic factor in patients with esophageal cancer. Key words: Esophageal neoplasms ; Prognosis ; Tomography, emission-computed; Tomography,X-ray computed ; Deoxyglucose
Glutamine Deprivation Regulates the Origin and Function of Cancer Cell Exosomes

Exosomes are secreted extracellular vesicles (EVs) carrying diverse cargos, which can modulate recipient cell behaviour. They are thought to derive from intraluminal vesicles formed in late endosomal multivesicular bodies (MVBs). An alternate exosome formation mechanism, which is conserved from fly to human, is described here, with exosomes carrying unique cargos, including the GTPase Rab11, generated in Rab11-positive recycling endosomal MVBs. Release of these exosomes from cancer cells is increased by reducing Akt/mechanistic Target of Rapamycin (mTORC1) signalling or depleting the key metabolic substrate glutamine, which diverts membrane flux through recycling endosomes. The resulting vesicles promote tumour cell proliferation and turnover, and modulate blood vessel networks in xenograft mouse models in vivo. Their growth-promoting activity, which is also observed in vitro, is Rab11a-dependent, involves ERK-MAPK-signalling and is inhibited by antibodies against Amphiregulin, an EGFR ligand concentrated on these vesicles. Therefore, glutamine depletion or mTORC1 inhibition stimulates release of Rab11a-exosomes with pro-tumorigenic functions, which we propose promote stress-induced tumour adaptation.
Obesity and Insulin Resistance Rates in a Population Under 40 Years Old Who Admitted to a Family Medicine Outpatient Clinic

1) Eskişehir Osmangazi Üniversitesi Tıp Fakültesi Aile Hekimliği Ana Bilim Dalı, Doç. Dr., Eskişehir 2) Eskişehir Osmangazi Üniversitesi Tıp Fakültesi Aile Hekimliği Ana Bilim Dalı, Araş. Gör. Dr., Eskişehir 3) Eskişehir Osmangazi Üniversitesi Tıp Fakültesi Biyoistatistik Ana Bilim Dalı, Araş. Gör. , Eskişehir 4) Eskişehir Osmangazi Üniversitesi Tıp Fakültesi Aile Hekimliği Ana Bilim Dalı, Prof. Dr., Eskişehir
Strategic Opinion Language on the US Courts of Appeals

What strategies do judges employ when they anticipate review? Constrained judges behave strategically by using particular instruments—like language complexity—when authoring opinions. Prior studies suggest that judges use complexity in anticipation of legislative hostility. Similarly, the threat of review and reversal may spur opinion complexity. This study examines variations in circuit court opinions resulting from precedent treatment and Supreme Court preferences. When a circuit negatively treats a Supreme Court precedent that the justices prefer or a circuit positively treats a precedent that the justices dislike, opinion complexity should increase. These hypotheses find support, suggesting that circuits strategically insulate using opinion complexity.
Gender differences in the associations of reappraisal and humor styles

Abstract Reappraisal is an effective emotion regulation strategy that draws on cognitive processes–like changing one’s thoughts to change one’s feelings–that are similar to those implicated in humor. Yet, very little is known about the links between the dispositional tendency to use reappraisal and individuals’ humor styles (e. g. aggressive, affiliative, self-deprecating, self-enhancing). Importantly, there are gender differences both in emotion regulatory processes and in the use of humor styles. We examined gender differences in reported use of humor styles, the associations between reappraisal and humor styles, and whether gender moderated those associations. Participants (N=250) were recruited through Amazon Mechanical Turk and self-reported their dispositional use of reappraisal and four humor styles. Men reported greater use of aggressive humor compared to women. Dispositional use of reappraisal was positively associated with self-enhancing humor. In addition, reappraisal use was positively related to greater use of affiliative humor, and this association was stronger for men than women. For men, greater use of reappraisal was associated with greater use of self-defeating humor, but reappraisal was negatively associated with self-defeating humor for women. Findings extend insight from prior work and suggest that both reappraisal and specific ways of using humor draw on aspects of self-regulatory competence rooted in cognitive change abilities, and the patterns of association differ in interesting ways for men and women.
Sharing of Heavy Equipment

Technological advances enable new business models for heavy equipment manufacturers, replacing or augmenting ownership-based models with access-based consumption. An ever-increasing list of peer-to-peer sharing platforms (e.g., Trringo by Mahindra, Yard Club by Caterpillar, or COOP by Ryder) shows that it is paramount for decision-makers to understand the economic implications of such business models. However, in this changing landscape, the efficacy of relying on access-based consumption is unclear, and a lack of empirical performance data motivates the need for analytical insights. This study seeks to understand the performance of different emerging business models, particularly peer-to-peer product sharing models, by considering salient economic and operational factors in the context of heavy equipment. Although such sharing business models are widely publicized, the optimal model for a heavy equipment manufacturer will depend on operational factors linked to after-sales services, a point which has been previously overlooked and which deserves closer attention from decision-makers. We determine the threshold at which a heavy equipment manufacturer may prefer setting up a sharing platform for its products, which provides support for the emergence of such manufacturer-owned platforms in practice. We also describe the optimal design of a sharing platform, highlighting the need to subsidize one part of the business (sharing) in order to benefit another (after-sales services). Moreover, we provide insight into how manufacturers can leverage after-sales services when threatened by the entrance of a third-party sharing platform.
EFFECT OF 4 WEEK SIMPLE BALANCE EXERCISE ON BALANCE ABILITY IN THAI ELDERLY

The objective of this study was to evaluate the short-term effects of 4 weeks balance training program by using simple daily activity living exercise training program on balance ability in Thai elderly person. Forty two participants (36 females and 6 males) were randomly divided into two groups: training (n=21) and control group (n=21). In exercise group, simple balance training was performed at nursing home and controlled by the researcher. Participants were trained once per day, 5 days per week for 4 weeks. In control group, participants were asked to maintain their normal physical activities throughout the experimental period. The two groups of subjects were assessed their balance abilities using single leg balance time test (SLBT) and 3-m timed up and go test, (TUGT) at pre- and post- training program. Balance ability was compared between exercise and control group using Mann-Whitney U test. Within group comparison was used Wilcoxon matched-pair signed-rank test. The level of statistically significant difference for all analyses was set at p-value less than 0.05. The results found that after 4 weeks, the improvement of balance abilities was demonstrated by increment of SLBT and decrement of TUGT in exercise group (P < 0.05). Moreover subjects in exercise group achieved significantly higher of percent change in the balance ability than subject in control group (P < 0.05). The present study indicated that the designed balance training program used in this study has shown successful effects on improving balance ability for the elderly to prevent falls. Since its ease to use and simply to perform anywhere, anytime in every household, therefore this program should be recommend for the elderly people. (Journal of Sports Science and Technology 2015;15(1): 203-211 )
Single-cell RNA expression profiling of ACE2, the putative receptor of Wuhan 2019-nCoV, in the nasal tissue

A novel coronavirus (2019-nCoV) was first identified in Wuhan, Hubei Province, and then spreads to the other Provinces of China. WHO decides to determine a Public Health Emergency of International Concern (PHEIC) of 2019-nCoV. 2019-nCov was reported to share the same receptor, Angiotensin-converting enzyme 2 (ACE2), with SARS-Cov. Here based on the public single-cell RNA-Seq datasets, we analyzed the ACE2 RNA expression profile in the tissues at different locations of the respiratory tract. The result indicates that the ACE2 expression appears in nasal epithelial cells. We found that the size of this population of ACE2-expressing nasal epithelial cells is comparable with the size of the population of ACE2-expression type II alveolar cells (AT2) in the Asian sample reported by Yu Zhao et al. We further detected 2019-nCoV by polymerase chain reaction (PCR) from the nasal-swab and throat-swab of seven suspected cases. We found that 2019-nCoV tends to have a higher concentration in the nasal-swab comparing to the throat-swab, which could attribute to the ACE2-expressing nasal epithelial cells. We hope this study could be informative for virus-prevention strategy development, especially the treatment of nasal mucus.
Efeito da Ansiedade Competitiva sobre a Tomada de Decisão em Jovens Atletas de Voleibol

Resumo O objetivo do estudo foi analisar o efeito da ansiedade competitiva sobre a tomada de decisão de jovens atletas de voleibol. A amostra foi composta por 24 voluntários do sexo masculino (16,06 ±0,65 anos). Utilizou-se a versão brasileira do Competitite State Anxiety Inventory para avaliar a ansiedade competitiva. A tomada de decisão foi avaliada em situação real de jogo, adotando-se os critérios do Game Performance Assessment Instrument (GPAI). Localizaram-se correlações negativas da ansiedade cognitiva e ansiedade somática com o índice de tomada de decisão (p<0,05). Revelaram-se correlações positivas entre a “autoconfiança” e o índice de tomada de decisão (p<0,05). Revelou-se influência da ansiedade cognitiva, somática e autoconfiança no índice de tomada de decisão (p<0,05). Concluiu-se que a ansiedade pode ser considerada um fator interveniente na tomada de decisão.
Oil Prices and Exchanges Rate Co-Movements: Empirical Evidence from Sudan

This study applies exponential generalized autoregressive conditional heteroscedastic approach to model oil price and exchange rate in the context of the Sudanese economy. Daily observations are used in the analysis covering the period January 2008 to December 2018. The findings of the study illustrated that oil returns (fluctuations) have statistically significant impact on the current values of returns on exchange rate. Specifically, the results indicate that that an increase of 10% in crude oil price returns will lead to approximately 0.39% depreciation of the Sudanese Pound against the US dollar. Regarding the volatility transmission, the estimated results indicate that exchange rate fluctuations measured by the conditional volatility is significantly influenced by volatility experienced in oil market. These results may have important implications and of great interest for monetary policies aiming at controlling oil inflationary pressures.
How Maternal Childhood Maltreatment Negatively Impacts Children’s Mental Health Outcomes Among Polysubstance Exposed Children

by MANDY A. FAUBLE The objective of this study is to enhance understanding of processes by which intergenerational risk factors for child maltreatment are passed through families. The study explores associations between maternal history of childhood maltreatment, and children’s mental health outcomes. The study addresses significant gaps in the literature on intergenerational aspects of childhood maltreatment. Much research has been devoted to establishing the relationship between maternal childhood maltreatment and the likelihood her children will also become victims; a well known connection. What is not understood is how this occurs; in terms of identifying both intergenerational risk factors and mediating processes to explain how these risks move through generations. This study first explores the connection between maternal childhood maltreatment and a known risk factor for child maltreatment in the next generation; poor mental health outcomes. The study draws upon theories of attachment, psychopathology, developmental psychopathology, and social learning to create and evaluate a hypothesized mediational model to explain this relationship. 133 mother-child dyads formed the sample. The mothers and children are from a high-risk substance abusing sample, and a primarily low socioeconomic status and African American community. The study used secondary data analysis, and a non-
Évaluation d’un entraînement basé sur le jeu de faire semblant destiné à favoriser le développement des compétences socio-émotionnelles chez les enfants de cinq ans : étude exploratoire

L’objectif de cette recherche etait d’evaluer les effets d’un programme d’entrainement base sur le jeu de faire semblant destine a favoriser le developpement des competences socio-emotionnelles. Dix-neuf enfants âges de cinq ans ont ete evalues a l’aide d’un paradigme pre-test, entrainement (groupe experimental vs temoin), post-test. Le groupe experimental a beneficie d’un programme de onze semaines d’une heure hebdomadaire durant les heures de classe portant sur les competences socio-emotionnelles – telles que la comprehension des emotions, la regulation des emotions negatives et le comportement prosocial – tandis que le groupe temoin n’a beneficie d’aucune intervention specifique. Les resultats montrent une amelioration partielle de l’habilete a comprendre les emotions et a reguler les emotions negatives chez les enfants ayant beneficie du programme d’entrainement. Toutefois, aucune progression significative n’a ete constatee aux epreuves mesurant le comportement prosocial pour le groupe experimental. Ces resultats suggerent qu’un entrainement base sur le jeu de faire semblant favorise le developpement de certains aspects des competences emotionnelles, plutot que le comportement prosocial.
Integrated Molecular Analysis for the Identification and Validation of Novel Biomarkers for Renal Cell Carcinoma and the Small Renal Mass

Renal cell carcinoma (RCC) constitutes an array of morphologically and genetically distinct tumors with varying clinical behavior, prognosis and response to therapy. RCC is frequently diagnosed incidentally as an early-stage small renal mass (SRM; pT1a, ≤ 4 cm). Overtreatment of patients with benign or clinically indolent SRMs is increasingly common and has resulted in a recent shift in treatment recommendations. There are currently no available biomarkers that can accurately predict risk of clinical progression. Additionally, there are no biomarkers that can accurately classify RCC. To that end, we developed an integrated label-free LC-MS/MS proteomics and peptidomics approach and targeted parallel-reaction monitoring (PRM) to identify early non-invasive biomarkers of RCC progression. In addition, we performed qRT-PCR to identify prognostic (predict early RCC progression) and diagnostic (RCC subtype classification) miRNAs. We identified biomarkers which displayed differential expression in clear cell RCC-SRMs (ccRCC-SRMs) compared to healthy controls and renal oncocytoma (≤ 4 cm). Additionally, we identified biomarkers which displayed differential expression in progressive relative to non-progressive ccRCC-SRMs. A two-protein signature (EPS8L2 and
The role of dietary zinc and CuZnSOD gene expression in response to oxidative stress in the lung and brain

The balance between the antioxidant defenses and the rate of production of reactive oxygen species (ROS), or oxidative stress, is believed to be a critical factor that determines the extent of tissue injury in a number of diseases. The antioxidant defenses, which consist of a network of enzymes, proteins and low molecular weight scavengers, function to protect cellular components against the damaging effects of ROS. This dissertation work focuses on the functional role of two components of the antioxidant defense system: the trace element zinc, and the antioxidant enzyme copper-zinc superoxide dismutase (CuZnSOD). This work was initiated based on accumulating evidence indicating that ROS mediated tissue injury may be a common pathogenic mechanism in several diseases associated with premature birth, including bronchopulmonary dysplasia and cerebral palsy, and that low antioxidant status may be a critical determinant of disease progression. We have hypothesized that low zinc nutritional status and reduced CuZnSOD activity increases the potential for ROS mediated tissue damage in lung and brain tissue. Further, we proposed that exposure to oxygen therapy, a common treatment strategy applied to premature infants, would markedly increase oxidative tissue damage in these tissues. To test this hypothesis we used an animal model to examine the effects of dietary zinc deficiency, reduced CuZnSOD expression and exposure to hyperoxia on oxidative tissue damage in lung and ii brain tissue. In addition, we examined the stress response of antioxidant metalloproteins that may play a critical role in maintaining homeostasis under oxidative stress, and have also performed a global analysis of gene expression in the brain of zinc deficient animals using cDNA microarray technology. Results from the first set of experiments demonstrated that exposure to hyperoxia increased oxidative tissue damage in the lung and also induced the expression of ceruloplasmin and metallothionein, suggesting that these metalloproteins may function as antioxidants in addition to their role in trace metal homeostasis. Subsequent work in brain tissue demonstrated that reduced expression of CuZnSOD increased oxidative tissue damage following exposure to hyperoxia, thus demonstrating the deleterious consequences of a compromised antioxidant defense system. And finally, the microarray analysis demonstrated that in the brain there are a number of genes from different cellular pathways whose expression is changed in response to zinc deficiency.