Miracle-dz/UniFAR-FTUs huggingface dataset:
Low Dose Ketamine Infusion for Comorbid Posttraumatic Stress Disorder and Chronic Pain: A Randomized Double-Blind Clinical Trial

Objective To date, treatment options (i.e. psychotherapy, antidepressant medications) for patients with posttraumatic stress disorder (PTSD), are relatively few, and considering their limited efficacy, novel therapies have gained interest among researchers and treatment providers alike. Among patients with chronic pain (CP) about one third experience comorbid PTSD, which further complicates their already challenging pharmacological regimens. Low dose ketamine infusion has shown promise in PTSD, and in treatment of CP, however they have not been studied in comorbid population and under rigorous control conditions. Methods We compared the effects of a single dose of either ketamine (0.5 mg/kg) or ketorolac (15 mg) over a 40-minute of IV infusion in CP patients with and without PTSD, in double blind, randomized study. Measures were collected before, during, one day and seven days after the infusion. A planned sample size of 40 patients randomly assigned to treatment order was estimated to provide 80% power to detect a hypothesized treatment difference after the infusion. Main Outcome and Measures: The primary outcome measures were change in PTSD symptom severity assessed with the Impact of Event Scale–Revised (IES-R) and Visual Analogue Scale (VAS) for pain administered by a study clinician 24 hours post infusion. Secondary outcome measures included Impact of Event Scale–Revised (IES-R), VAS and Brief Pain Inventory (Short Form) for pain 1 week after the infusion. Results Both treatments offered comparable improvement of PTSD and CP symptoms that persisted for 7 days after the infusion. Patients with comorbid PTSD and CP experienced less dissociative side effects compared to the CP group. Surprisingly, ketorolac infusion resulted in dissociative symptoms in CP patients only. Conclusions This first prospective study comparing effects of subanesthetic ketamine versus ketorolac infusions for comorbid PTSD and CP, suggests that both ketamine and ketorolac might offer meaningful and durable response for both PTSD and CP symptoms.
Predictors of Adherence Toward Specific Domains of Diabetic Self-Care Among Type-2 Diabetes Patients

Background: Adequate knowledge, awareness, and adherence to diabetic self-care practices are vital tools to protect patients from risks of disease complications, developing comorbidity and mortality. Therefore, this study aimed to assess specific domains of diabetic self-care practice and associated factors among patients with type-2diabetes in Hawassa University Comprehensive Specialized Hospital, Sidama regional state. Materials and methods: A hospital-based cross-sectional study design was conducted on 217 patients with type 2 diabetes from January 01 to April 30, 2020. A structured questionnaire and the Summary of Diabetes Self-Care Activities (SDSCA) tool were used to collect relevant data through interviewer administration. Statistical analysis was done using SPSS version 23. Results: A total of 207 patients with type-2 diabetes were participated in the study with a 95% response rate. Overall 47.8% (95%CI: 41.2-55) of patients adhered to diabetic self-care practice. Concerning the specific domain of self-care practice, 54.6%, 39.1%, 28%, and 65.2% of patients adhered to a healthy diet, physical exercise, self-monitoring blood glucose (SMBG), and diabetic foot care practices, respectively. Besides, all patients received at least 80% of the prescribed doses and frequency of anti-diabetic agents and 60.4% had good glycemic control. Receipt of advice from treating physicians and having no familial history of diabetes were significantly associated with adherence toward eating a healthy diet, diabetic foot care, and SMBG. While male sex was associated with adherence toward healthy diet management. Moreover, having glucometer, age, male sex, diabetes duration ⩾ 5 years, and anti-diabetic treatment modality were associated with adherence toward SMBG. Conclusion: This study indicates 52.2%, 72%, and 60.1% of diabetes patients did not adhere to diabetic self-care, SMBG, and physical exercise, respectively. Improving awareness and regular diabetic education is imperative to scale up patients’ adherence toward diabetic self-care practice.
Proportion of alemtuzumab-treated patients converting from relapsing-remitting multiple sclerosis to secondary progressive multiple sclerosis over 6 years

Background Few data exist concerning conversion to secondary progressive MS in patients treated with disease-modifying therapies. Objective Determine the proportion of alemtuzumab-treated patients converting from relapsing-remitting to secondary progressive MS during the CARE-MS core and extension studies. Methods Patients (N = 811) were analyzed post hoc for secondary progressive MS conversion. Optimal conversion definition: Expanded Disability Status Scale (EDSS) score ≥4, pyramidal functional system score ≥2, and confirmed progression over ≥3 months including confirmation within the functional system leading to progression, independent of relapse. Results Over 6.2 years median follow-up, 20 alemtuzumab-treated patients converted (Kaplan-Meier estimate, 2.7%; 95% confidence interval, 1.8%–4.2%). Sensitivity analysis accounting for dropouts showed similar results (3%), as did analyses using alternative definitions with different EDSS thresholds and/or confirmation periods, and analysis of core study subcutaneous interferon beta-1a-treated patients who received alemtuzumab in the extension. Patients converting to secondary progressive MS were older, and had higher EDSS scores and greater brain lesion volumes at baseline, but did not need additional alemtuzumab or other therapies. Conclusions The 6-year conversion rate to secondary progressive MS was low for alemtuzumab-treated patients, supporting further study of the role alemtuzumab may play in reducing risk of secondary progression. ClinicalTrials.gov identifiers: NCT00530348, NCT00548405, NCT00930553.
The Model of Domestic Product Quality Syndrome

This paper aims to develop and test a model that involves consumer ethnocentrism, world-mindedness, patriotism, and domestic product quality syndrome. This research used a quantitative approach. Data were collected through a survey of 222 respondents in Jakarta, Indonesia. The respondents are consumer electronic product users. Structural equation modeling (SEM) analysis was used to test the conceptual model and hypotheses. The results of this research show that the conceptual model has a good fit. We found that consumer ethnocentrism has a positive and significant impact on domestic product quality syndrome. We also found that patriotism significantly influences consumer ethnocentrism, while world-mindedness does not significantly influence consumer ethnocentrism. Data were collected only in Jakarta. Furthermore, a convenience sampling technique was applied. Thus, the findings of this research may not be generalized to other contexts. Therefore, future studies involving larger respondents coming from diverse areas are required to improve the generalization of the results and examine the stability of this research’s findings. Company should align its strategy and quality objectives with the level of consumer ethnocentrism and patriotism to overcome domestic product quality syndrome. There is a lack of research that develops and tests a model that can be used to explain the phenomenon of domestic product quality syndrome. This research fulfills the literature gaps.
The Personality Traits in the Defense Industry: The Mediating Role of Organizational Citizenship Behavior

Employees display various behaviors which also include work-related behaviors such as Job Satisfaction, Organizational Citizenship Behavior, and Innovative Work Behavior. The exploration of the relationship among the Big Five Personality Traits, Job Satisfaction, Organizational Citizenship Behavior, and Innovative Work Behavior of the employees working in the companies providing services for the Turkish Defense Industry serves as the primary aim of this study. Hence, the study was conducted on the employees of defense companies through face-to-face interviews and questionnaire forms. The results of this study demonstrate that the Big Five Personality Traits directly affects the changes in Job Satisfaction and Organizational Citizenship Behavior. Besides, Organizational Citizenship Behavior has a mediating role in the relationship between Big Five personality Traits and Job Satisfaction, which directly affects the changes in Innovative Work Behavior. This study primarily targeted to provide evidence and create an understanding of how employees’ intrinsic characteristics shape the attitudes and behaviors in the workplace according to the scores of Big Five Inventory as well as statistical research techniques. This study contributes to the literature by investigating the defense employees’ personality traits and the results show that personality traits are a pivotal factor in achieving corporate’s strategic goals.
Effectiveness of a Manual Therapy Program as Adjuvant Treatment for School-Age Children With Attention-Deficit/Hyperactivity Disorder: A Randomized Pilot Study

Attention-deficit/hyperactivity disorder (ADHD) is a neurobiological disorder. Common symptoms are inattention, hyperactivity, impulsivity, and executive functions deficit, often with comorbidities. Main treatment involves pharmacological and non-pharmacological therapies (cognitive-behavioral therapy, psycho-pedagogical programs). Emerging non-pharmacological treatments include manual therapies (MTs) in mental health. Several MT techniques have shown effectiveness in ADHD. The objectives of this study are as follows: (a) to assess short-term effects and persistence of an MT program on neuropsychological (hyperactivity index through the Conners’ Global Index [CGI]) and neurophysiological (time–frequency domain parameters of heart rate variability [HRV]) variables in ADHD children, and (b) to test the feasibility of the design. This study was approved by the Parc Tauli Corporation Clinical Research Ethics Board (#2017311). Pilot, controlled, multidisciplinary study of eight children with ADHD randomly assigned to control group (CG; n = 4) and intervention group (IG; n = 4). Both followed multimodal treatment, and IG also received an MT program per week for 4 weeks. A physiotherapist and a psychologist analyzed short-term effects (1-week post-program) and persistence (36 weeks). Eight children (boys, 62.5%; girls, 37.5%) with an average age of 10.375 ± 0.74 years were included. Baseline HRV parameters showed basal sympathetic predominance. The MT program increased the parasympathetic activity, which was significantly maintained at 1 to 36 weeks; there were no changes in CG. One-week post-program IG showed significant CGI reduction (–7 points, p = .016*), CG without changes (p = .41), with significant differences CG – IG (p = .0097*), and very large effect size (d = 2.235); 36 weeks post-program showed no effects (IG, p = .293; CG, p = .247), without differences CG – IG (p = .369). The MT program reduced the hyperactivity index with a 1-week persistence and increased the parasympathetic activity with a 36-week persistence. More investigations are needed to generalize the outcomes. Additional research is planned to further explore the possibilities of MT in psychiatric disorders with autonomic imbalances.
Reading outcomes in children with developmental language disorder: A person-centered approach

Background and aims Many children with Developmental Language Disorder (DLD) develop reading difficulties. The purpose of this study is to better understand variation in the reading outcomes of children with DLD using a person-centered approach. Method 87 monolingual Dutch children diagnosed with DLD performed at ages 5 or 6 years nine tests of nonverbal IQ, oral language proficiency, phonological memory (PM) and executive functioning (EF). Two years later, the same children were tested on single (non-)word reading. Latent profile analyses were conducted to identify profiles based on oral language proficiency, phonological memory and executive functioning at age 5–6 years, which, in turn, were related to nonverbal IQ and to single-word reading two years later. Results Four profiles were identified and labelled relative to their position within the DLD-sample: 1. Weak performance overall, 2. Strong EF-average language and PM, 3. Mild working memory (WM) deficiencies-average language and PM, 4. Strong development overall. Profiles 1 and 3 had below average nonverbal IQ scores and were associated with low word reading outcomes two years later. Conclusions Within the group of children with DLD, children with relatively weak oral language, phonological memory and executive functioning, or children with working memory deficiencies are most at risk for developing reading difficulties. The findings support a multiple risk framework and confirm that a person-centered approach is promising in predicting reading outcomes in DLD. Implications: Research into individual differences in DLD is dominated by variable-centered approaches. This study illustrates how a person-centered approach, which views variables as properties of individuals, captures variation in the DLD-population. Using this bottom-up approach, the study highlights how an individual’s strengths and weaknesses across different developmental domains can be combined into profiles that relate to later reading outcomes. As such, it can provide an example for future DLD research.
Community Partnership Through Knowledge Transfer Program: Assessment From the Perspectives of Academics’ Experience

The knowledge transfer program (KTP) in Malaysia was instituted to facilitate knowledge transfer, collaboration, and interaction between academics in public higher institutions and other stakeholders. These programs are divided into community or industry programs. Under the community program, academics collaborate with a community partner to utilize their research findings in the community environment. This quantitative study attempts to assess KTP based on academics’ postproject responses to online questionnaires. The participants in this study consist of 132 academics of Malaysian public universities of Rolling 1 to Rolling 4 projects between 2011 and 2016. Of 132 individuals invited to participate, 84 of them (64%) took part in the online survey. These data were analyzed using analysis of variance (ANOVA) and Duncan’s range test. The findings indicate that the KTP has enabled academics, irrespective of position, to deploy their ideas and knowledge in a real-world community setting. The relationship between academic position and learning experience in transferring knowledge, however, is inverse: the higher the level of an academic position, the lower the learning experience. The findings also exhibit the experience and challenges that one would expect from the involvement of academics in a community KTP.
Receptive Arts Engagement for Health: A Holistic and Trans-Disciplinary Approach to Creating a Multisensory Environment

Multisensory environments are increasingly being used in health care settings with reported benefits including relaxation, supporting self-regulation, enhancing mood, and reducing chronic pain. However, limited research exists that explores the impact of multisensory environment design on engagement. In response, this article presents a qualitative study exploring the creative design attributes that cultivated participant engagement and shaped their overall experience of spending time in an artistically created multisensory environment: the Sensory-Art Space (SAS). A maximum variation approach to sampling was used to select 18 participants. Data were gathered via semi-structured interviews and were audio-recorded and transcribed verbatim before being analyzed thematically. Our findings produced three key themes. The first two themes were: the ambience of everything and variation: it’s always my choice, which identified aspects of the artistic design that fostered engagement and the sense of connection and ownership of the SAS captured in the third theme, a space that’s yours. Based on analysis of participant responses, creative design considerations were identified that could assist the development of future multisensory spaces and highlighted the importance of a holistic and curatorial approach to enhance engagement value.
Caution: Rumors ahead—A case study on the debunking of false information on Twitter

As false information may spread rapidly on social media, a profound understanding of how it can be debunked is required. This study offers empirical insights into the development of rumors after they are debunked, the various user groups who are involved in the process, and their network structures. As crisis situations are highly sensitive to the spread of rumors, Twitter posts from during the 2017 G20 summit are examined. Tweets regarding five rumors that were debunked during this event were manually coded into the following categories: rumor, debunking message, uncertainty about rumor, uncertainty about debunking message, and others. Our findings show that rumors which are debunked early and vehemently by official sources are the most likely to be stopped. When individuals participate in the process, they typically do so by sharing uncommented media content, as opposed to contributing user-generated content. Depending on the conditions in which a rumor arises, different network structures can be found. Since some rumors are easier for individuals to verify than others, our results have implications for the priorities of journalists and official sources.
Establishment and tracking control of trapezoidal steering wheel angle model for autonomous vehicles

Human drivers have rich and diverse driving characteristics on curved roads. Finding the characteristic quantities of the experienced drivers during curve driving and applying them to the steering control of autonomous vehicles is the research goal of this article. We first recruited 10 taxi drivers, 5 bus drivers, and 5 driving instructors as the representatives of experienced drivers and conducted a real car field experiment on six curves with different lengths and curvatures. After processing the collected driving data in the Frenet frame and considering the free play of a real car’s steering system, it was interesting to observe that the shape enclosed by steering wheel angles and the coordinate axis was a trapezoid. Then, we defined four feature points, four feature distances, and one feature steering wheel angle, and the trapezoidal steering wheel angle (TSWA) model was developed by backpropagation neural network with the inputs were vehicle speeds at four feature points, and road curvature and the outputs were feature distances and feature steering wheel angle. The comparisons between TSWA model and experienced drivers, model predictive control, and preview-based driver model showed that the proposed TSWA model can best reflect the steering features of experienced drivers. What is more, the concise expression and human-like characteristic of TSWA model make it easy to realize human-like steering control for autonomous vehicles. Lastly, an autonomous vehicle composed of a nonlinear vehicle model and electric power steering (EPS) system was established in Simulink, the steering wheel angles generated by TSWA model were tracked by EPS motor directly, and the results showed that the EPS system can track the steering angles with high accuracy at different vehicle speeds.
The Psychometric Properties of the Turkish Version of the Riverside Life Satisfaction Scale–Adult Form

We validated the psychometric properties of the Riverside Life Satisfaction Scale for Turkish culture. A standard back-translation procedure was performed. A stratified sample (N = 493; age range = 18–70 years) was selected from North Cyprus. Results showed that one-factor model for the Riverside Life Satisfaction Scale was a good fit. Composite reliability was . 77 and factor loadings were significant (.515–.825). Significant correlations were found between the scale and the Satisfaction With Life Scale, Psychological Well-Being Scale–Short Form, Positive and Negative Affect Schedule, and extraversion, agreeableness, conscientiousness, and neuroticism subscales of the Big Five Inventory. The Riverside Life Satisfaction Scale is an up-to-date, standard, and powerful alternative scale that is statistically strong, easy-to-apply, and its reversed items were free from measurement bias. It is thus valid and reliable to use in Turkish culture, indicating the cross-cultural value of the current study.
A new numerical method for the tensile property analysis of discontinuous fiber-reinforced thermoplastics

For predicting the mechanical properties of discontinuous carbon fiber-reinforced thermoplastics (DCFRTP), it is essential to consider the microstructure, including the fiber orientation and the properties of the constituting materials. In the present study, a heterogeneous particle model, considering the microscopic factors, is constructed on the basis of the peridynamic (PD) theory to investigate the tensile properties of DCFRTP. Two kinds of randomly oriented DCFRTP, with different constituents and volume fractions of carbon fiber, are used for the verification of this numerical model. A comparison between the PD simulations and the experimental results shows a good agreement. The effect of the model size on the prediction is discussed.
Surface Structural Study on Ionic Liquids Using Metastable Atom Electron Spectroscopy

The surface structures of ionic liquids 1-CnH2n+1-3-methylimidazolium tetrafluoroborate (BF4−), trifluoromethanesulfonate (OTf) and bis(trifluoromethylsulfonyl)amide (TFSA) with n = 4, 8, and 10 were investigated by ultraviolet photoemission spectroscopy (UPS) and metastable atom electron spectroscopy (MAES). The MAES spectra reveal that the anions and cations share the surface of the room-temperature ionic liquids (RTILs) with a shorter alkyl chain at n = 4 although the alkyl chain layer tends to cover the outermost surface in the case of RTILs with longer alkyl chains of n = 8 and 10. Comparison of UPS and MAES spectra demonstrates that the nonpolar groups such as the alkyl chain and the CF3 group point toward the vacuum side, while the polar groups such as the SO3 and SO2 groups face toward the bulk side. A double-layered structure at the surface, which consists of an alkyl chain layer and a polar layer containing anions and imidazolium rings, is proposed from these observations.