Miracle-dz/UniFAR-FTUs huggingface dataset:
Induction of Secondary Metabolite Biosynthesis by Deleting the Histone Deacetylase HdaA in the Marine-Derived Fungus Aspergillus terreus RA2905

Aspergillus terreus is well-known for its ability to biosynthesize valuable pharmaceuticals as well as structurally unique secondary metabolites. However, numerous promising cryptic secondary metabolites in this strain regulated by silent gene clusters remain unidentified. In this study, to further explore the secondary metabolite potential of A. terreus, the essential histone deacetylase hdaA gene was deleted in the marine-derived A. terreus RA2905. The results showed that HdaA plays a vital and negative regulatory role in both conidiation and secondary metabolism. Loss of HdaA in A. terreus RA2905 not only resulted in the improvement in butyrolactone production, but also activated the biosynthesis of new azaphilone derivatives. After scaled fermentation, two new azaphilones, asperterilones A and B (1 and 2), were isolated from ΔhdaA mutant. The planar structures of compounds 1 and 2 were undoubtedly characterized by NMR spectroscopy and mass spectrometry analysis. Their absolute configurations were assigned by circular dichroism spectra analysis and proposed biosynthesis pathway. Compounds 1 and 2 displayed moderate anti-Candida activities with the MIC values ranging from 18.0 to 47.9 μM, and compound 1 exhibited significant cytotoxic activity against human breast cancer cell line MDA-MB-231. This study provides novel evidence that hdaA plays essential and global roles in repressing secondary metabolite gene expression in fungi, and its deletion represents an efficient strategy to mine new compounds from A. terreus and other available marine-derived fungi.
A Bias Correction Scheme with the Symmetric Cloud Proxy Variable and Its Influence on Assimilating All-Sky GOES-16 Brightness Temperatures

All-sky assimilation of brightness temperatures (BTs) from GOES-16 infrared water vapor channels is challenging, primarily because these channels are sensitive to cloud ice that causes large nonlinear errors in the forecast and forward models. Thus, bias correction (BC) for all-sky assimilation of the GOES-16 BTs is vital. This study examines the impacts of different BC schemes, especially for a scheme with a quartic polynomial of cloud predictors (ASRBC4 scheme), on the analysis and WRF model forecasts of tropical cyclones when assimilating the all-sky GOES-16 channel 8 BTs using the NCEP GSI-based 3D ensemble-variational hybrid data assimilation (DA) system with Variational BC (VarBC). Long-term statistics are performed during the NASA Convective Processes Experiment field campaign (2017). Results demonstrate that the ASRBC4 scheme effectively reduces the average of all-sky scaled observation-minus-backgrounds (OmBs) in a cloudy sky and alleviates their nonlinear conditional biases with respect to the symmetric cloud proxy variable, in contrast to the BC schemes without the cloud predictor or with a first-order cloud predictor. In addition, adopting the ASRBC4 scheme in DA decreases the positive temperature increments at 200 hPa and the accompanying mid-level cyclonic wind increments in the analysis of Tropical Storm (TS) Cindy (2017). Applying the ASRBC4 scheme also leads to better storm track predictions for TS Cindy (2017) and Hurricane Laura (2022), compared to experiments with other BC schemes. Overall, this study highlights the importance of reducing nonlinear biases of OmBs in a cloudy sky for successful all-sky assimilation of BTs from GOES-16 infrared water vapor channels.
Visual reweighting using stroboscopic vision in healthy individuals

Testing how individuals use visual information to maintain balance has been traditionally limited to two extreme conditions: eyes closed and eyes open. Stroboscopic glasses allow clinicians to control the amount of visual information that influences balance, varying between eyes open and closed. Seventeen uninjured participants completed the sensory organization test (SOT) under three visual conditions: full occlusion, high occlusion (i.e., 100ms transparent, 400ms opaque), and low occlusion (i.e., 100ms transparent, 100ms opaque). Equilibrium scores were calculated from the Neurocom Balance Master system during double-limb stance and the three-trial average from each condition and SOT was used for analysis. A two-way repeated measures ANOVA was used to evaluate the interaction between and within factors of vision (i.e., full occlusion, high occlusion, low occlusion, and no occlusion) and support surface (i.e., firm and sway). Increased visual occlusion negatively impacts balance on a firm surface and is amplified when somatosensory cues are unreliable. These findings highlight the importance of somatosensory cues as a guiding sensory modality for balance, especially when vision is occluded.
A measurement of quality costs in industrial organizations

Abstract This paper aims to determine the level of awareness and implementation of measuring CoQ in MIEs in Yemen. In contrast, this study was based on the traditional CoQ Prevention—Appraisal—Failure (PAF) model. Also, this paper proposes a suitable model for measuring CoQ in MIEs based on the research results. The Applied research focused on large companies where CoQ programs in the majority of companies operate as a subsystem of underlying management. Managers of large companies use indicators to control and evaluate performance for production quality. Still, they usually do not develop a separate framework for measuring and assessing CoQ. As a result, this research attempted to answer the question, Are Yemeni industrial companies interested in measuring, analyzing, and reporting CoQ items (prevention, appraisal, and failure costs) concerned in their industry? It also determines the extent these companies are interested in measuring, and analyzing hidden CoQ. According to this research findings, most major companies in Yemen are aware of and practice measuring CoQ. At the same time, the study showed that these companies are still not interested in measuring the hidden CoQ in their manufacturing.
GOODS 850-5: A z > 4 Galaxy Discovered in the Submillimeter?

We report an SMA interferometric identification of a bright submillimeter source, GOODS 850-5. This source is one of the brightest 850 μm sources in the GOODS-N but is extremely faint at all other wavelengths. It is not detected in the GOODS HST ACS images and only shows a weak 2 σ signal at 1.4 GHz. It is detected in the Spitzer IRAC bands and the MIPS 24 μm band, however, with very low fluxes. We present evidence in the radio, submillimeter, mid-IR, near-IR, and optical that suggest GOODS 850-5 may be a z > 4 galaxy.
Galactic chemical evolution of sulphur - Sulphur abundances from the [S i] λ1082 nm line in giants

Context. The Galactic chemical evolution of sulphur is still under debate. At low metallicities some studies find no correlation between [S/Fe] and [Fe/H], which is typical for a-elements, while others find [S/Fe] increasing towards lower metallicities, and still others find a combination of the two. Each scenario has different implications for the Galactic chemical evolution of sulphur. Aims. The aim of this study is to contribute to the discussion on the Galactic chemical evolution of sulphur by deriving sulphur abundances from non-local thermodynamic equilibrium (LTE) insensitive spectral diagnostics in disk and halo stars with homogeneously determined stellar parameters. Methods. We derived effective temperatures from photometric colours, surface gravities from stellar isochrones and Bayesian estimation, and metallicities and sulphur abundances from spectrum synthesis. We derived sulphur abundances from the [SI] lambda 1082 nm line in 39 mostly cool and metal-poor giants using 1D LTE MARCS model atmospheres to model our high-resolution near-infrared spectra obtained with the VLT, NOT, and Gemini South telescopes. Results. We derive homogeneous stellar parameters for 29 of the 39 stars. Our results argue for a chemical evolution of sulphur that is typical for a-elements, contrary to some previous studies that have found high sulphur abundances ([S/Fe] >= 0.6) for stars with -2.5 < [Fe/H] < -1. Our abundances are systematically higher by about 0.1 dex than those of other studies that arrived at similar conclusions using other sulphur diagnostics. Conclusions. We find the [SI] line to be a valuable diagnostic of sulphur abundances in cool giants down to [Fe/H] similar or equal to -2.3. We argue that a homogeneous determination of stellar parameters is necessary, since the derived abundances are sensitive to them. Our results ([S/Fe]) agree reasonably well with predictions of contemporary models of Galactic chemical evolution. In these models sulphur is predominantly created in massive stars by oxygen burning and is ejected into the interstellar medium during Type II supernovae explosions. Systematic differences with previous studies most likely fall within modelling uncertainties. (Less)
Antioxidant and Immune Stimulating Effects of Allium hookeri Extracts in the RAW 264.7 Cells and Immune-Depressed C57BL/6 Mice

We investigated the antioxidant and immune-enhancing effects of the extracts from Allium hookeri leaves and roots (AHL and AHR) in in vitro and in vivo models. Their antioxidant effects were determined by total phenolic content (TPC), DPPH and ABTS radical scavenging activities, and superoxide dismutase and catalase activities. The immunomodulatory effects were evaluated by nitric oxide (NO) production and cytokine concentrations produced from RAW 264.7, and by serum IgA and IgG levels, cytokine levels, and NK cell activities in the immunosuppressed C57BL/6 mice. AHL and AHR extracts improved antioxidant activities and productions of NO and cytokines without cytotoxicity in the RAW 264.7 cells. AHL and AHR groups showed significantly higher serum IgA and IgG levels, Th1 cytokine concentrations, splenocyte proliferations, and NK cell activities than the NC group which was not treated with AHL or AHR extract. AHR extract showed higher values than AHL extract in the factors evaluated in this study. The results show that they have high antioxidant and immunomodulatory effects and can be used as novel potential therapeutic candidates to treat related diseases and to improve public health.
HOW DO MOST PLANETS FORM?—CONSTRAINTS ON DISK INSTABILITY FROM DIRECT IMAGING

Core accretion and disk instability have traditionally been regarded as the two competing possible paths of planet formation. In recent years, evidence has accumulated in favor of core accretion as the dominant mode, at least for close-in planets. However, it might be hypothesized that a significant population of wide planets formed by disk instabilities could exist at large separations, forming an invisible majority. In previous work, we addressed this issue through a direct imaging survey of B2–A0-type stars and concluded that <30% of such stars form and retain planets and brown dwarfs through disk instability, leaving core accretion as the likely dominant mechanism. In this paper, we extend this analysis to FGKM-type stars by applying a similar analysis to the Gemini Deep Planet Survey sample. The results strengthen the conclusion that substellar companions formed and retained around their parent stars by disk instabilities are rare. Specifically, we find that the frequency of such companions is <8% for FGKM-type stars under our most conservative assumptions, for an outer disk radius of 300 AU, at 99% confidence. Furthermore, we find that the frequency is always <10% at 99% confidence independently of outer disk radius, for any radius from 5 to 500 AU. We also simulate migration at a wide range of rates and find that the conclusions hold even if the companions move substantially after formation. Hence, core accretion remains the likely dominant formation mechanism for the total planet population, for every type of star from M-type through B-type.
Molinia caerulea alters forest Quercus petraea seedling growth through reduced mycorrhization

Abstract Oak regeneration is jeopardized by purple moor grass, a well-known competitive perennial grass in the temperate forests of Western Europe. Below-ground interactions regarding resource acquisition and interference have been demonstrated and have led to new questions about the negative impact of purple moor grass on ectomycorrhizal colonization. The objective was to examine the effects of moor grass on root system size and ectomycorrhization rate of oak seedlings as well as consequences on nitrogen (N) content in oak and soil. Oak seedlings and moor grass tufts were planted together or separately in pots under semi-controlled conditions (irrigated and natural light) and harvested 1 year after planting. Biomass, N content in shoot and root in oak and moor grass as well as number of lateral roots and ectomycorrhizal rate in oak were measured. Biomass in both oak shoot and root was reduced when planting with moor grass. Concurrently, oak lateral roots number and ectomycorrhization rate decreased, along with a reduction in N content in mixed-grown oak. An interference mechanism of moor grass is affecting oak seedlings performance through reduction in oak lateral roots number and its ectomycorrhization, observed in conjunction with a lower growth and N content in oak. By altering both oak roots and mycorrhizas, moor grass appears to be a species with a high allelopathic potential. More broadly, these results show the complexity of interspecific interactions that involve various ecological processes involving the soil microbial community and need to be explored in situ.
Embeddings of discrete series into induced representations of semisimple Lie groups, II, -Generalized Whittaker models for $SU(2, 2)$-

T h is is the second part of our w ork on embeddings o f discrete series into various, im portant induced m odules for semisimple Lie g roups. A pp ly ing th e general method established in the first p a r t [10] (referred a s [ I ] la ter o n ) , w e describe in this paper (generalized) Whittaker models for the sim ple L ie group SU (2, 2) in a n explicit way. To be precise, we consider representations smoothly induced from characters of the unipotent r a d ic a l o f a cuspidal parabolic subgroup. T h e infinitesimal embeddings of discrete series a re determined almost completely f o r su ch in d u ced m o d u le s . Among o th e r th in g s , th ro u g h th is se r ie s o f w orks w e find all the embeddings into GelfandGraev representations, and also the zero-th n-cohomologies f o r t h e d isc re te se ries of SU(2, 2). N o te th a t o u r g ro u p is o f rea l rank tw o, and that it is locally isomorphic to th e (restricted) conformal group on the M inkowski space. N ow , let G be a connected semisimple Lie group w ith finite center, and K a maximal compact subgroup of G . W e alw ays assum e the rank condition : rank(G)=rank(K), which is necessary and sufficient fo r G to have a non-empty discrete series [2 ]. Each discrete series 7A o f G has a unique lowest K-type r2 w ith h ighest w eigh t 2(see 1.1). F urther, th e representation 7rA can b e rea lized o n th e L 2 -kernel of gradient-type, G invariant differential operator D,i(see [7], c f . [ I , T h . 1.5]). T h is DA is defined on the G-vector bundle over K\G attached to the K-module From this realization o f rh, w e can deduce that th e L 2 -kernel o f DA characterizes the embeddings o f :rn, the contragredient of It A, in to th e left regular representation of G o n LAG ). In fac t, the exterior tensor product 7r1a7rA occurs in t h e bi-regular representation o f G xG ju s t once, and the functions in L 2 -Ker(D 2 ) give rise to low est K-type vectors in L 2 (G) of type rt c7rIIK w ith respect to th e le ft K-action. Suggested by this fac t, w e form ulated in the first half of [ I ] a general method for describing infinitesimal embeddings of discrete series into C-induced G -m odules. This is d o n e b y le t t in g t h e opera to r D A a c t on the r'-com ponent o f th e induced module 3r(n)=C -Ina7 (77) mentioned above, in a natural w ay (see 1.3 fo r the the precise definit io n ) . W e h av e sh o w n tha t, a s in th e regular representation case, solutions yo of the
Comments on multibrane solutions in cubic superstring field theory

In a previous paper, we have studied multi-brane solutions in the context of cubic superstring field theory. The kinetic term of the action was computed for these multi-brane solutions, and for the evaluation of the energy, the equation of motion contracted with the solutions itself was simply assumed to be satisfied. In this paper, we compute the cubic term of the action and discuss the validity of the previous assumption. Additionally, we evaluate the Ellwood's gauge invariant observable.
Mixed valency in cerium oxide crystallographic phases: Valence of different cerium sites by the bond valence method

We have applied the bond valence method to cerium oxides to determine the oxidation states of the Ce ion at the various site symmetries of the crystals. The crystals studied include cerium dioxide and the two sesquioxides along with some selected intermediate phases which are crystallographically well characterized. Our results indicate that cerium dioxide has a mixed-valence ground state with an f-electron population on the Ce site of 0.27 while both the A- and C-sesquioxides have a nearly pure f1 configuration. The Ce sites in most of the intermediate oxides have nonintegral valences. Furthermore, many of these valences are different from the values predicted from a naive consideration of the stoichiometric valence of the compound.
Comparison of total energy intakes estimated by 24-hour diet recall with total energy expenditure measured by the doubly labeled water method in adults

BACKGROUND/OBJECTIVES The doubly labeled water (DLW) method is the gold standard for estimating total energy expenditure (TEE) and is also useful for verifying the validities of dietary evaluation tools. In this study, we compared the accuracy of total energy intakes (TEI) estimated by the 24-h diet recall method with TEE obtained using the doubly labeled water method. SUBJECTS/METHODS This study involved 71 subjects aged 20–49 yrs. Over a 14-day period, three 24-h diet recalls per subject (2 weekdays and 1 weekend day) were used to estimate energy intakes, while TEE was measured using the DLW method. The paired t-test was used to determine the significance of differences between TEI and TEE results, and the accuracy of the 24-h recall method was determined by accuracy predictions percentage, root mean square error, and bias. RESULTS Average study subject age was 33.4 ± 8.6 yrs. The association between TEI and TEE was positive and significant (r = 0.463, P < 0.001), and the difference between TEI (2,084.3 ± 684.2 kcal/day) and TEE (2,401.7 ± 480.3 kcal/day) was also significant (P < 0.001). In all study subjects, mean TEI was 12.0% (307.5 ± 629.3 kcal/day) less than mean TEE, and 12.2% (349.4 ± 632.5 kcal/day) less in men and 11.8% (266.7 ± 632.5 kcal/day) less in women. Rates of TEI underprediction for all study subjects, men, and women, were 60.5%, 51.4%, and 66.7%, respectively. CONCLUSIONS This study shows that 24-h diet recall underreports energy intakes. More research is needed to corroborate our findings and evaluate the accuracy of 24-h recall with respect to additional demographics.
Service with a Smile: The Differential Effects of Emotional Labor on Boundary Spanners in the Banking Industry

Abstract The study uncovered the effect of emotional labor strategies on job satisfaction and emotional exhaustion. A conceptual framework was developed using extant literature which led to the examination of Deep Acting and Surface Acting, which are the two main strategies of emotional labor. Data was collected from front line employees of banks in Zimbabwe using a structured questionnaire, and was analyzed using SPSS. The results revealed that Deep Acting leads to job satisfaction and reduced emotional exhaustion. Surface Acting was found to be inversely related to Job Satisfaction and positively related to Emotional Exhaustion.
Matrix models as non-commutative field theories on

In the context of spin foam models for quantum gravity, group field theories are a useful tool allowing on the one hand a non-perturbative formulation of the partition function and on the other hand admitting an interpretation as generalized matrix models. Focusing on 2d group field theories, we review their explicit relation to matrix models and show their link to a class of non-commutative field theories invariant under a quantum-deformed 3d Poincaré symmetry. This provides a simple relation between matrix models and non-commutative geometry. Moreover, we review the derivation of effective 2d group field theories with non-trivial propagators from Boulatov's group field theory for 3d quantum gravity. Besides the fact that this gives a simple and direct derivation of non-commutative field theories for the matter dynamics coupled to (3d) quantum gravity, these effective field theories can be expressed as multi-matrix models with a non-trivial coupling between matrices of different sizes. It should be interesting to analyze this new class of theories, both from the point of view of matrix models as integrable systems and for the study of non-commutative field theories.
Evaluation of the nutrient quotient for the elderly (NQ-E) using congregate meal services according to their oral health conditions

BACKGROUND/OBJECTIVES The purposes of this study were to evaluate the nutritional status and dietary habits of the elderly using the nutrition quotient for the elderly (NQ-E) and to analyze the differences in the NQ-E according to their levels of oral health. SUBJECTS/METHODS The survey was administered to 123 elderly people receiving congregate meal services in Seoul. The questionnaire comprised 3 domains: oral health status, general characteristics, and the NQ-E for the elderly. RESULTS The respondents were divided into 2 groups based on the average score of their levels of oral health (the group with high oral health scores: 4.42 points and the group with low oral health scores: 2.89 points). As a result of evaluating nutritional status using the NQ-E, it was found that the average NQ-E score was 58.7 points, with 46.0 points in the balance domain, 47.0 points in the diversity domain, 72.9 points in the moderation domain, and 61.8 points in the dietary behavior domain. The NQ-E score (62.3 points) of the group with high oral health scores is significantly higher than the NQ-E score (54.7 points) of the group with low oral health scores (P < 0.001). Concerning the NQ domain scores, the elderly with good oral health status had “favorable” results in terms of balance and dietary behavior, and the elderly with poor oral health status had “favorable” results only in terms of balance. CONCLUSIONS Overall, several dietary areas needed improvement in general. Those with poor oral health conditions urgently needed to improve related factors to minimize the risk of increasing imbalanced nutrition and comorbidities due to insufficient nutrition and undesirable eating habits.
Deterministic Coherent Writing of a Long-Lived Semiconductor Spin Qubit Using One Ultrafast Optical Pulse

We use one single, few-picosecond-long, variably polarized laser pulse to deterministically write any selected spin state of a quantum dot confined dark exciton whose life and coherence time are six and five orders of magnitude longer than the laser pulse duration, respectively. The pulse is tuned to an absorption resonance of an excited dark exciton state, which acquires nonnegligible oscillator strength due to residual mixing with bright exciton states. We obtain a high-fidelity one-to-one mapping from any point on the Poincar\'e sphere of the pulse polarization to a corresponding point on the Bloch sphere of the spin of the deterministically photogenerated dark exciton.