Miracle-dz/UniFAR-FTUs huggingface dataset:
CMAR_A_278914 613..623

1Department of Radiation Oncology, Yantai Affiliated Hospital of Binzhou Medical University, Yantai, People’s Republic of China; 2Department of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, People’s Republic of China; 3Department of Radiology, Yantai Affiliated Hospital of Binzhou Medical University, Yantai, People’s Republic of China; 4Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, People’s Republic of China Purpose: Currently, there are no standard treatments for primary small cell carcinoma of the esophagus (PSCCE), particularly in cases of limited-stage disease. This retrospective study aimed to assess the treatment strategies and the relevant prognostic factors of limited-stage PSCCE (LS-PSCCE). Patients and Methods: We retrospectively evaluated 129 patients with LS-PSCCE between June 2009 and December 2018. The χ2 test was performed to examine the frequencies between different groups. The Kaplan-Meier and log-rank methods were used to estimate and compare survival rates. Univariate and multivariate analyses were performed to determine the prognostic factors for overall survival (OS). Results: Through a median follow-up of 23 months, the median OS of all patients was 25.0 months and the median recurrence-free survival (RFS) was 15.0 months. Univariate and multivariate analyses showed that alcohol abuse (p=0.046) and TNM stage (p<0.001) were independent prognostic factors. There was no significant difference in OS and RFS rates between the patients treated with chemoradiotherapy (CRT) and those treated with surgery and chemotherapy with or without radiotherapy (S+CT±RT) (p>0.05). Patients who received concurrent CRT had better OS and RFS than those who received sequential CRT (p<0.05). Postoperative adjuvant RT for high-risk patients can further improve the local control rate but has no significant effect on OS. Conclusion: LS-PSCCE patients treated with CRT had similar OS and RFS compared to those treated with S+CT±RT. This study shows that concurrent CRT confers a survival advantage for patients with LS-PSCCE compared to those with sequential CRT.
PPA_A_272211 2315..2326

1Real World Value & Evidence, Janssen Scientific Affairs, LLC, Titusville, NJ, USA; 2Analysis Group, Inc., Montréal, QC, Canada; 3Early Compound Development, Janssen Research & Development, LLC, Titusville, NJ, USA Purpose: Darunavir, cobicistat, emtricitabine, and tenofovir alafenamide can be used as a single-tablet regimen (STR, DRV/c/FTC/TAF) or multiple-tablet regimen (MTR, DRV/c +FTC/TAF) to treat patients with human immunodeficiency virus (HIV). This study described treatment patterns and predictors of adherence among patients with HIV initiated on DRV/c/ FTC/TAF or DRV/c+FTC/TAF. Patients and Methods: A retrospective longitudinal study was conducted using linked claims and electronic medical records from Decision Resources Group’s Real World Data Repository (7/ 17/2017–6/1/2019). Treatment-naïve and treatment-experienced virologically suppressed adults with HIV-1 prescribed DRV/c/FTC/TAF or DRV/c+FTC/TAF (index date) were included. Sixmonth persistence (no treatment gaps >60 and >90 days) and adherence (proportion of days covered [PDC]) to the index regimen were evaluated among patients with ≥6 months of observation postindex. Predictors of low adherence (PDC<80%) were evaluated using a logistic regression model. Results: Among 2633 eligible patients (49.5 years old, 29% female, 37% African American/ Black), 12% were treatment-naïve pre-index and 88% switched from a previous antiretroviral therapy; 84% initiated DRV/c/FTC/TAF and 16% initiated DRV/c+FTC/TAF. Among 822 DRV/ c/FTC/TAF patients with ≥6 months of observation post-index, 80% and 86% had no >60and >90-day gaps in DRV/c/FTC/TAF coverage, respectively, while among 204 DRV/c+FTC/TAF patients with ≥6 months of observation post-index, 69% and 75% had no >60and >90-day gaps in DRV/c+FTC/TAF coverage, respectively. Mean (median) PDC for the index regimen was 81% (93%) for patients treated with DRV/c/FTC/TAF and 73% (83%) for patients treated with DRV/c+FTC/TAF. Predictors of low adherence included younger age (odds ratio [OR]=2.36, p=0.017), higher Quan-Charlson comorbidity index (OR=1.32, p=0.012), use of MTR regimen at index (OR=1.69, p=0.022), and prior low adherence (OR=2.56, p<0.001). Conclusion: Among patients initiating a DRV/c-based regimen, those initiating STR had higher 6-month adherence/persistence than those initiating MTR, highlighting the potential benefits of the STR formulation, particularly among younger patients with multiple comorbidities and prior low adherence.
(2019). Biodiversity reporting for governmental organisations: Evidence from English local councils. Accounting, Auditing and Accountability Journal .

Purpose: Editorial boards of academic journals represent a key institutional mechanism in the governance and functioning of the academic community. Board members play an important role in knowledge production and development of the discipline. This exploratory study enquires into the diversity characteristics of boards of accounting journals. Design: Drawing on a diversity framework that distinguishes between societal diversity and value of diversity, the paper examines two board characteristics: gender diversity and internationalisation. Moreover, it examines the influence of three journal and two editor characteristics on board diversity and analyses trends over time. Findings: On gender, overall board trends are consistent with societal diversity and value of diversity: boards reflect the gender profile of senior academics. Further, female representation on boards is broadly consistent across the different journal nationalities; has improved over time; converged between traditionally ‘ gender sensitive ’ sub-disciplines; and is influenced by female editorship. However, inequities appear to be present at the highest level: women appear to be less well represented as editors and also have a lower representation on boards of higher ranked journals than those with lower ranked journals. On internationalisation, once again overall trends broadly reflect societal diversity and value at diversity. However, international scholars are less well represented in 4* journals versus 2* and 3* journals and in US journals versus Australian and UK journals. Further, there are signs of weakening US dominance in non-US journals. Originality: Drawing on the diversity framework, this study is the first comprehensively to examine gender diversity and internationalisation of accounting boards.
Pro ﬁ le of Cabozantinib for the Treatment of Hepatocellular Carcinoma: Patient Selection and Special Considerations

: Management of advanced hepatocellular carcinoma is challenging. With an increasing number of options for the ﬁ rst and second-line treatment, understanding and developing optimal systemic treatment strategies are crucial. In second line, two tyrosine kinase inhibitors (TKI) and one monoclonal antibody have been approved after sorafenib by both the European Medicines Agency and the Food and Drug Administration based on the results of phase 3 trials: cabozantinib, regorafenib and ramucirumab. Cabozantinib has demonstrated an improved overall survival and progression-free survival in the phase 3 CELESTIAL study in second and third line, in patients in good general condition (perfor-mance status 0 – 1) and with a normal liver function Child-Pugh class A. Analysis of subgroups has shown that even elderly patients over 65 years, or patients with high baseline alpha-fetoprotein ≥ 400 ng/mL bene ﬁ t from cabozantinib. The choice in second-line between the three drugs should be based on factors such as previous tolerance of sorafenib, safety pro ﬁ le of drugs and quality of life. In this review, we will analyze clinical data available on cabozantinib, clarifying the choice between the different possible treatments. However, the upcoming of a new standard in ﬁ rst line with the combination atezolizumab and bevacizumab will change the game and will warrant further investigations to de ﬁ ne the accurate subsequent sequence of TKIs. Cabozantinib is also actually tested in ﬁ rst-line in combination with atezolizumab, results of the phase 3 COSMIC trial are eagerly awaited. cabozantinib, MET, alpha-fetoprotein, AFP, tyrosine kinase inhibitor
An Outlook on Truth Maintenance.

Abstract : Truth maintenance systems (TMS) have been used in several recent problem-solving systems to record justifications for deduced assertions, to track down the assumptions which underlie contradictions when they arise, and to incrementally modify assertional data structures when assumptions are retracted. This report describes a TMS algorithm that is substantially different from previous systems. This algorithm performs deduction in traditional propositional logic in such a way that the premise set from which deduction is being done can be easily manipulated. A novel approach is also taken to the role of a TMS in larger deductive systems. In this approach the TMS performs all propositional deduction in a uniform manner while the larger system is responsible for controlling the instantiation of universally quantified formulae and axiom schemas.
Clariﬁcations Regarding the 3 * Repeat Region of the cagA Gene in Helicobacter pylori and Clinical Outcome

In a recent issue, Rota et al. (2) reported a study regarding the 39 repeat region of the cagA gene of Helicobacter pylori in which they classified the cagA 39 region into three types (A, B/D, and C) according to our previous report (5). They reported no association between 39 repeat region subtypes and clinical outcome. However, multiple subtypes of the cagA repeat region were associated with gastric ulcer. Unfortunately, the PCR primers they used are located outside of the repeat regions, and strains isolated from East Asian and non-Asian countries are detected by PCR using these primers. As we previously described, the sequences of the second repeat regions in strains from East Asia are completely different from those in strains from non-Asian countries (3, 4). Non-Asian strains possess 102-bp second repeat regions, and East Asian strains possess 162-bp second repeat regions (3–5). Therefore, subtypes A through D cannot be applied to non-Asian strains. In East Asian strains, types A (around 648 bp) and B (around 756 bp) have one second repeat region and types C (around 810 bp) and D (around 756 bp) have two second repeat regions. The expected lengths of the PCR products in East Asian strains are equal to (423 ; 432) 1 (57 3 f) 1 (162 3 s), where f is the number of first repeat regions and s is the number of second repeat regions. In contrast, the expected lengths of PCR products in non-Asian strains are equal to (486 ; 498) 1 (57 3 f) 1 (102 3 s) bp. We found that typically (.95%) there was only one first repeat region in non-Asian strains (3, 4) such that the expected lengths of the PCR products are (543 ; 555) 1 (102 3 s) bp. Thus, 650-, 750-, and 850-bp fragments indicate H. pylori with one, two, and three cagA non-Asian type second repeat regions, respectively, which is in complete agreement with data by Rota et al. confirming that the Brazilian strains have a non-Asian cagA structure. We reported that non-Asian H. pylori strains with three or more second repeat regions were associated with gastric atrophy and intestinal metaplasia (3). Recently, Kidd et al. reported that, compared to the prevalence in patients with gastritis alone, the prevalence of the shortest PCR fragment in the 39 region of the cagA gene was high in peptic ulcer patients and the prevalence of the longest fragment was high in patients with gastric cancer (1). Rota et al. also noted that the presence of multiple genotypes in the cagA repeat region was associated with gastric ulcer (which is typically associated with pangastritis and some atrophy) but not with duodenal ulcer (which typically has a nonatrophic gastritis) (2). Although neither Rota et al. nor Kidd et al. provided data about the presence of atrophy, both reports are consistent with the hypothesis that cagA second repeat regions are associated with the premalignant condition of gastric atrophy. Finally, the “Japanese methodology” was developed in Houston, Tex. (3).
READING ANXIETY AND READING COMPREHENSION OF INDONESIAN UNIVERSITY EFL STUDENTS

This study aimed to investigate the relationship between foreign language reading anxiety and the reading performance STAIN Pamekasan EFL learners. This study also aimed to compare the level of reading anxiety between male student and female students. The data were collected from the sixth semester students majoring English Teaching and Learning Program of Tarbiyah Department, STAIN Pamekasan, Indonesia. The data were collected using Foreign Language Reading Anxiety Scale (FLRAS) which focuses to measure the level of anxiety in reading skill. The data were analyzed using SPSS version 16 and Pearson Product Moment correlation is used to determine the degree of reading anxiety and Independent T-test is used to measure the significant difference between reading anxiety of male and female students. The results revealed that students experienced high reading anxiety and there is positive low correlation between reading anxiety level and reading comprehension. However, no significance difference was found between the level of foreign language reading anxiety between male and female students.
cells for RNA yield.

Objective: Buccal cells are an ideal surrogate tissue for studying biologic effects of carcinogens or drugs, however inherent fragility and salivary RNAses limit RNA yield. We conducted healthy volunteer trials to optimize collection conditions. Methods: We conducted: (a) a single-arm crossover study evaluating four test conditions on RNA yield by buccal cytobrush; (b) a single-arm prospective study evaluating RNA yield by investigator vs self-collection. Results: Antecedent toothbrushing, time of day, and number of cytobrush strokes did not significantly impact RNA yield. RNA yield was doubled by using 2 vs 1 cytobrush per buccal surface ( P = .0054). Self-collection of buccal cells for RNA was feasible; 36 of 50 (72%) samples passed quality control. Conclusion: RNA yield was doubled by using two cytobrushes per buccal surface. Healthy volunteers can self-collect sufficient buccal RNA for gene expression studies. Techniques from these pragmatic trials could enhance availability of a limited tissue for serial biomarker measurements. Level of Evidence: 1b — Prognosis Study (Individual prospective cohort study).
NEW OBSERVATIONS ON PERMIAN STRATIGRAPHY IN GREECE AND GEODYNAMIC INTERPRETATION

New detailed stratigraphic and micropaleontological works on the famous exposures of Permian rocks in Hydra rich in Foraminifera, allows to define the stratigraphy of other outcrops in Aegina, Salamis, Attica and Chios. A synthetic section is presented which is characterized by the development of 3 successive carbonate platforms during the Permian and by 4 main tectonostratigraphic events. The youngest of these events marks the closure of the Paleotethyan ocean and the collision of a former Gondwanian/Cimmerian passive margin in the S with an active margin in the N.
Ruxolitinib and interferon-α2 combination therapy for patients with polycythemia vera or myelofibrosis a phase II study

W e report the final 2-year end-of-study results from the first clinical trial investigating combination treatment with ruxolitinib and low-dose pegylated interferon- α 2 (PEG-IFN α 2). The study included 32 patients with polycythemia vera and 18 with primary or secondary myelofibrosis; 46 patients were previously intolerant of or refractory to PEG-IFN α 2. The primary outcome was efficacy, based on hematologic parame-ters, quality of life measurements, and JAK2 V617F allele burden. We used the 2013 European LeukemiaNet and International Working Group-Myeloproliferative Neoplasms Research and Treatment response criteria, including response in symptoms, splenomegaly, peripheral blood counts, and bone marrow. Of 32 patients with polycythemia vera, ten (31%) achieved remission complete remission (9%) myelofibrosis, remission; remissions. of peripheral blood count remission polycythemia myelofibrosis, The Myeloproliferative Neoplasm Symptom Assessment total symptom score from 22 [95% interval (95% CI):, 16-29] at baseline to 15 (95% CI: 10-22) JAK2 V617F allele burden 47% (95% CI: 33-61%) 12% (95% CI: 6-22%), 41% of a molecular response. The drop-out rate was 6% patients with polycythemia vera and 32% those with myelofibrosis. PEG-IFN α 2, 31 (86%) the study, (67%) of PEG-IFN α 2 the study. combination treatment cell counts, reduced bone marrow cellularity and fibrosis, JAK2 burden, reduced symptom burden toxicity in several patients with polycythemia myelofibrosis.
Global classical solution to 3D isentropic compressible Navier-Stokes equations with large initial data and vacuum

In this paper, we investigate the existence of a global classical solution to 3D Cauchy problem of the isentropic compressible Navier-Stokes equations with large initial data and vacuum. Precisely, when the far-field density is vacuum ($\widetilde{\rho}=0$), we get the global classical solution under the assumption that $(\gamma-1)^\frac{1}{3}E_0\mu^{-1}$ is suitably small. In the case that the far-field density is away from vacuum ($\widetilde{\rho}>0$), the global classical solution is also obtained when $\left((\gamma-1)^\frac{1}{36}+\widetilde{\rho}^\frac{1}{6}\right)E_0^{\frac{1}{4}}\mu^{-\frac{1}{3}}$ is suitably small. The above results show that the initial energy $E_0$ could be large if $\gamma-1$ and $\widetilde{\rho}$ are small or the viscosity coefficient $\mu$ is taken to be large. These results improve the one obtained by Huang-Li-Xin in \cite{Huang-Li-Xin}, where the existence of the classical solution is proved with small initial energy. It should be noted that in the theorems obtained in this paper, no smallness restriction is put upon the initial data. It can be viewed the first result on the existence of the global classical solution to three-dimensional Navier-Stokes equations with large initial energy and vacuum when $\gamma$ is near $1$.
ASSESSMENT OF THE CONTRASTING FACTORS IN THE SURVIVAL RATE OF ROAD INJURIES AT VARIOUS TERTIARY HEALTHCARE CENTERS

: Objective: Assessment of the contrasting factors in road injury survival including three tertiary care hospitals of an urban area. Methods: We conducted this study-based survey in the timeframe of September 2017 to October 2018 at Services Hospital, Lahore on all road traffic injury victims representing the three-health care centres. In this survey complete record of the patient is maintained including gender, mode, age and any delay in approaching hospital. Data were stratified by the hospital of presentation. A logistic regression model was formed, and the survival possibility was evaluated after balancing different risk factors, comprising patient data and severity of the injury. Results: The study comprised of 93,657 victims, but there is a lack of complete information in 6,458 (6.89%) study subjects, counting the information about survival. Generally, 83,837 (89.5%) were males; 64,269 (74%) were aged between 16 and 45 years; 84,016 (95%) had injury severity score of 15; however, the survival rate was 84,141 (96.5%). Conclusion: Remarkable variations were found in risk-adjusted survival of road injury victims representing public hospitals. These variations underlined the differences in chances for improvement and the process of care.
Evidence Synthesis for Decision Making 3

In meta-analysis, between-study heterogeneity indicates the presence of effect-modifiers and has implications for the interpretation of results in cost-effectiveness analysis and decision making. A distinction is usually made between true variability in treatment effects due to variation in patient populations or settings and biases related to the way in which trials were conducted. Variability in relative treatment effects threatens the external validity of trial evidence and limits the ability to generalize from the results; imperfections in trial conduct represent threats to internal validity. We provide guidance on methods for meta-regression and bias-adjustment, in pairwise and network meta-analysis (including indirect comparisons), using illustrative examples. We argue that the predictive distribution of a treatment effect in a “new” trial may, in many cases, be more relevant to decision making than the distribution of the mean effect. Investigators should consider the relative contribution of true variability and random variation due to biases when considering their response to heterogeneity. In network meta-analyses, various types of meta-regression models are possible when trial-level effect-modifying covariates are present or suspected. We argue that a model with a single interaction term is the one most likely to be useful in a decision-making context. Illustrative examples of Bayesian meta-regression against a continuous covariate and meta-regression against “baseline” risk are provided. Annotated WinBUGS code is set out in an appendix.
Low ‐ intensity Pulsed Ultrasound Ameliorates Angiotension Ii-induced Cardiac Fibrosisbyalleviating In�ammation via a Caveolin-1-dependent Pathway

Background: Cardiac hypertrophy and �brosis are major pathological manifestations observed in left ventricular remodeling induced by Angiotensin II (AngII). Concerning the fact that low ‐ intensity pulsed ultrasound (LIPUS) has been reported to improve cardiac dysfunction and myocardial �brosis in myocardial infarction (MI) through mechanotransductionanditsdownstream pathways, we aimed to investigate whether LIPUS could also exert a protective effect on ameliorating AngII-induced cardiac hypertrophy and �brosis andand if so, to further elucidate the underlying molecular mechanisms. Methods: In our study, we used AngII to mimic the animal and cell culture models of cardiac hypertrophy and �brosis, where LIPUS irradiation (0.5MHz, 77.20mW/cm 2 ) was applied for 20 minutes every 2 days from 1 week before surgery to 4 weeks after surgery in vivo, and every 6 hours for a total of 2 times in vitro. Following that, the levels of cardiac hypertrophy and �brosis were evaluated by echocardiographic, histopathological, and molecular biological methods. Results: Our results showed that LIPUS irradiation could ameliorate left ventricular remodeling in vivo and cardiac �brosis in vitro by reducing AngII-inducedrelease of in�ammatory cytokines, while the protective effects were limited on cardiac hypertrophy in vitro. Given that LIPUS irradiation increased the expression of caveolin-1 related to mechanical stimulation, we inhibited caveolin-1 activity with pyrazolopyrimidine 2 (pp2) in vitro, by which LIPUS-induced downregulation of in�ammation was reversed and the anti-�brosis effects of LIPUS irradiation were absent. Conclusions: Taken together, these results indicate that LIPUS irradiation could ameliorate AngII-induced cardiac �brosis by alleviating in�ammation via a caveolin-1-dependent pathway, providing new insights for the development of novel therapeuticapparatus in clinical practice. ameliorate AngII-induced �brosis increased expression of the mechanotransduction protein caveolin-1. �brosis by in�ammation and oxidative via a caveolin-1-dependent