Miracle-dz/UniFAR-FTUs huggingface dataset:
Application of in-situ cosmogenic nuclide analysis to landform evolution in Dartmoor, south-west Britain

Located beyond the southern limit of glaciation in Britain, the upland granitic terrain of Dartmoor, south-west England, has been exposed to long intervals of intense periglacial activity during the Pleistocene. This region has been significant in debates about appropriate models of long-term landscape change, most notably two-phase versus single-phase models of landform evolution, and the development of tors. However, given the previous lack of quantitative techniques capable of constraining denudation and specific process rates, and thereby testing developmental models for these features, there remains much uncertainty in the interpretation of the classic landforms of the region. This study measures concentrations of the cosmogenic nuclide 10Be produced in-situ in quartz within the upper few metres of the Earth surface. These reflect the history of near-surface exposure to cosmic radiation of sampled material, and allow for the interpretation of exposure age and/or erosion rates of the land surface. This research utilises these cosmogenic nuclide values to evaluate geomorphological processes and investigate key aspects of landform development. These include the formation of tors in non-glaciated regions, the development of regolith and boulderfields under periglacial conditions, and the derivation of catchment-averaged denudation rates. This study provides the first quantitative measurement of erosion on tor surfaces in Dartmoor, with typical rates of 14-45 mm ka-1. These are relatively high and comparable to other components of the landscape. In addition, there is no clear relationship of cosmogenic nuclide concentration to tor dimensions. It is shown that the tors are dynamic landforms and simple, two-stage development is an inappropriate model. Catchment-averaged denudation rates are derived and these long-term rates of 20-94 mm ka-1 are significantly higher than modern, short-term values. Finally, downslope transport in a palaeo-periglacial blockslope is investigated using 10Be concentrations. This variety of landforms and scale of investigation facilitates an integrated approach to the understanding of catchment-scale erosional dynamics. In addition, the complex nature of landform development that is evident in the area provides challenges to the application of in-situ cosmogenic nuclides and highlights both the potential and limitations of the technique.
Crosstalk between Endothelial Cells and Tumor Cells: A New Era in Prostate Cancer Progression

Prostate cancer stands as one of the most prevalent malignancies afflicting men worldwide. The tumor microenvironment plays a pivotal role in tumor progression, comprising various cell types including endothelial cells, tumor-associated fibroblasts, and macrophages. Recent accumulating evidence underscores the indispensable contribution of endothelial cells to prostate cancer development. Both endothelial cells and tumor cells release a multitude of factors that instigate angiogenesis, metastasis, and even drug resistance in prostate cancer. These factors serve as regulators within the tumor microenvironment and represent potential therapeutic targets for managing prostate cancer. In this review, we provide an overview of the crucial functions of endothelial cells in angiogenesis, metastasis, and drug resistance, and their prospective therapeutic applications in combating this disease.
Water flow and sediment grain size as co-varying SAV habitat requirements

This study examined the importance of water flow and sediment texture as co-varying habitat parameters of submerged aquatic vegetation (SAV) in the Chesapeake Bay. An outdoor mesocosm experiment was conducted to test the response of SAV (Zostera marina and Ruppia maritima) to combinations of water flows and sediment grain sizes characterized by sediment deposition, bedload transport and erosion. Water flow, sediment and SAV characteristics were also determined at vegetated and adjacent unvegetated areas at 11 study sites and sediment motion conditions assessed. Greater SAV biomass was developed by Z. marina and R. maritima experiencing sediment motion than sediment deposition. Although habitat parameter thresholds in situ were site-specific, overall SAV presence was limited to moderate ranges of both water flow and sediment grain size. All SAV habitat observed was characterized by sediment bedload transport. Consideration of both water flow and sediment habitat requirements will improve SAV restoration success.
The development of higher education in Croatia and its social dimension

U radu se daje pregled razvoja visokog obrazovanja u Hrvatskoj s naglaskom na njegovoj socijalnoj dimenziji, kao i prikaz empirijskih istraživanja drustvenih nejednakosti u visokom obrazovanju. Posebno se ukazuje na cinjenicu da intenzivan razvoj visokog obrazovanja u Hrvatskoj, kako u socijalistickom tako i u postsocijalistickom razdoblju, nije bio pracen ostvarivanjem drustvene jednakosti u visokom obrazovanju. U visokom obrazovanju također su zadržane rodne razlike. One se ocituju u vecoj zastupljenosti žena u tradicionalno ženskim podrucjima studija (npr. uciteljski studiji, studiji u drustveno-humanistickom podrucju), a muskaraca u tradicionalno muskim podrucjima studija (npr. informatika i tehnicki studiji).
Facies and sedimentary environments of the cretaceous La Luna Formation in San Pedro Del Rio section, Venezuelan Andes: A multidisciplinary study

Vertical variations in facies and sedimentary environments in an outcrop of the La Luna Formation in the Venezuela Andes were evaluated with an integrated study of sedimentology, micropaleontology, palynology, visual kerogen, organic geochemistry and field geology. Up to now, the La Luna Formation, main hydrocarbon source rock in the Maracaibo Basin, has been considered for calculations of oil generation as an homogeneous interval with similar properties across the basin. However, this study reveals important vertical variations in organic facies and sedimentary environments. The microfacies range from almost pure carbonate (recrystallized) mudstone to almost pure shale, with a varying organic content. An overall upward change from oxic to anoxic environments can be recognized, culminating in a chert-rich interval (Ftanita de Tachira Member). The total organic carbon content is high throughout, with the exception of low to moderate values in the chert. The organic matter is mature to postmature. Phosphatic intervals are also developed, supporting a model of platform-edge upwelling and high organic productivity. The presence of rare volcanic grains suggests comtemporaneous volcanic activity within adjacent areas (Colombian Andes ).
Contact toxicity and repellent activity of essential oils from Alpinia zerumbet cv. ‘Variegata’ against stored product insects

ABSTRACT Alpinia zerumbet cv. ’Variegata’, as a special spice, has attracted social attention for its potential to replace synthetic chemicals as insecticides and repellents in food protection. In this work, the essential oils (EOs) from different organs of Alpinia zerumbet cv. ’Variegata’ (stem and leaf, flower, and rhizome) were extracted by hydrodistillation and analyzed by gas chromatography-mass spectrometry (GC-MS). The contact toxicities and repellent activities of the extracted EOs, along with their common components, against three insect species (Tribolium castaneum, Lasioderma serricorne, and Liposcelis bostrychophila) were evaluated. GC-MS analysis identified 25 components, and eucalyptol and camphor were the common primary components in the three EOs. The result showed that EOs and the main components (eucalyptol and camphor) exhibited varying degrees of contact toxicity and repellent activity against three insect species. Camphor exhibited more obvious contact toxicity than eucalyptol against both insect species (L. serricorne and L. bostrychophila), but the toxic effect was opposite for T. castaneum. The gray relation analysis explained that REOA had the strongest repellency against L. serricorne, with a coefficient of 0.52. The results in this study suggest that EOs of A. zerumbet cv. ’Variegata’ have the potential to be developed into botanical insecticides and repellents to control stored-product insects.
Public mass shootings cause large surges in Americans’ engagement with gun policy

Abstract As public mass shootings continue to plague the United States, a growing scholarly literature seeks to understand the political effects of these tragic events. This literature, however, focuses on public opinion or turnout and vote choice, leaving open to question whether or not public mass shootings affect a range of other important actions citizens may take to engage with gun policy. Leveraging the as-good-as random timing of high-publicity public mass shootings over the past decade and an immense array of publicly available and proprietary data, we demonstrate that these events consistently cause surges in public engagement with gun policy—including internet searches, streaming documentaries, discussion on social media, signing petitions, and donating to political action committees. Importantly, we document the behaviors where shootings induce polarizing upswings in engagement and those where upswings skew toward gun control. Finally, we demonstrate that low-publicity shootings largely exert little-to-no effect on our outcomes.
Assessing Cross-Sectional Association of Uremic Pruritus with Serum Heavy Metal Levels: A Single-Center Study

(1) Background: Uremic pruritus (UP) is a common and taxing symptom in patients on maintenance hemodialysis (MHD). We have previously shown that blood lead levels (BLLs) and blood aluminum levels (BALs) were separately positively associated with UP in MHD patients. We also found that blood cadmium levels (BCLs) were positively associated with all-cause mortality and cardiovascular-related mortality in MHD patients. We wondered whether there is any correlation between BCLs and UP after adjusting for BLLs and BALs. (2) Methods: Patients enrolled in this study were all from three hemodialysis (HD) centers at Chang Gung Memorial Hospital, Lin-Kou Medical Center, including both the Taipei and Taoyuan branches. Correlations between UP and BLLs, BALs, BCLs, and other clinical data were analyzed. (3) Results: Eight hundred and fifty-three patients were recruited. Univariate logistic regressions showed that diabetes mellitus, hepatitis B virus infection, hepatitis C virus infection, HD duration, hemodiafiltration, dialysis clearance of urea, normalized protein catabolic rate, non-anuria, serum albumin levels, log (intact-parathyroid hormone levels), total serum cholesterol levels, serum low-density lipoprotein levels, log (blood aluminum levels), and log (blood lead levels) were associated with UP. Although log BCLs were not significantly associated with UP (p = 0.136) in univariate analysis, we still included log BCLs in multivariate logistic regression to verify their effect on UP given that our aim in this study was to verify associations between serum heavy metals and UP. Multivariate logistic regressions showed that log BLLs (OR: 27.556, 95% CI: 10.912–69.587, p < 0.001) and log BALs (OR: 5.485, 95% CI: 2.985–10.079, p < 0.001) were positively associated with UP. The other logistic regression, which stratified BLLs and BALs into high and low BLLs and BALs, respectively, showed that high BLLs or high BALs (low BLLs and low BALs as reference) (OR: 3.760, 95% CI: 2.554–5.535, p < 0.001) and high BLLs and high BALs combined (low BLLs and low BALs as reference) (OR: 10.838, 95% CI: 5.381–21.828, p < 0.001) were positively correlated with UP. (4) Conclusions: BLLs and BALs were positively correlated with UP. BCLs were not correlated with UP. Clinicians should pay more attention to the environmental sources of lead and aluminum to prevent UP.
Greening the Future: Harnessing ICT, Innovation, Eco-Taxes, and Clean Energy for Sustainable Ecology—Insights from Dynamic Seemingly Unrelated Regression, Continuously Updated Fully Modified, and Continuously Updated Bias-Corrected Models

This research endeavors to investigate the impacts of information and communication technology, green technological innovation, and environmental tax on the attainment of ecological sustainability with advanced panel date estimation for 2001–2019. The results of this study demonstrate a noteworthy inverse relationship between information and communication technology and ecological footprint, suggesting that progress in ICT has the potential to yield positive consequences in terms of ecological restoration and the promotion of environmental sustainability. Furthermore, this study underscores the significance of GTI in mitigating carbon emissions and effectively addressing environmental challenges. The findings indicate that the incorporation of environmentally sustainable technology can yield favorable ecological consequences and make significant contributions towards the attainment of worldwide climate targets. Nevertheless, the study highlights the importance of considering potential rebound effects. It underscores the imperative for ongoing research and the implementation of comprehensive policies within the realm of environmentally sustainable technology. Moreover, the present study elucidates the favorable ramifications of GF on ecological sustainability, underscoring its pivotal contribution in curtailing carbon emissions, augmenting environmental benchmarks, and facilitating the ecological footprint. Enhancing the utilization of green finance, making adjustments to national regulatory frameworks, and achieving harmonization of public financial incentives to bolster sustainable development are important. Additionally, the study posits that the incorporation of ET can catalyze businesses and individuals to embrace environmentally friendly energy sources and sustainable practices, thereby fostering positive outcomes for the environment. The study offers significant insights into the contributions of information and communication technology, green technology innovation, and environmental technology to advancing ecological sustainability. It emphasizes the need for collaborative endeavors among academia, industry, and government to cultivate a supportive ecosystem for sustainable development.
Fixed/Preassigned-Time Synchronization of Fully Quaternion-Valued Cohen–Grossberg Neural Networks with Generalized Time Delay

This article is concerned with fixed-time synchronization and preassigned-time synchronization of Cohen–Grossberg quaternion-valued neural networks with discontinuous activation functions and generalized time-varying delays. Firstly, a dynamic model of Cohen–Grossberg neural networks is introduced in the quaternion field, where the time delay successfully integrates discrete-time delay and proportional delay. Secondly, two types of discontinuous controllers employing the quaternion-valued signum function are designed. Without utilizing the conventional separation technique, by developing a direct analytical approach and using the theory of non-smooth analysis, several adequate criteria are derived to achieve fixed-time synchronization of Cohen–Grossberg neural networks and some more precise convergence times are estimated. To cater to practical requirements, preassigned-time synchronization is also addressed, which shows that the drive-slave networks reach synchronization within a specified time. Finally, two numerical simulations are presented to validate the effectiveness of the designed controllers and criteria.
Diagnostic Efficacy of Serological Antibody Detection Tests for Hepatitis Delta Virus: A Systematic Review and Meta-Analysis

Background and Aims Coinfection of hepatitis delta virus (HDV) with hepatitis B virus (HBV) causes the most severe form of viral hepatitis, and the global prevalence of HDV infection is underestimated. Although serological testing of anti-HDV antibodies is widely used in the diagnosis of HDV, its diagnostic efficacy remains unclear. This study aimed to evaluate the diagnostic efficacy of HDV serological tests, the results of which may assist in the diagnosis of HDV. Methods Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines were followed. The PubMed, Web of Science and Cochrane Library databases were searched from the beginning to 31 May 2023. Study quality was assessed using the Quality Assessment of Diagnostic Accuracy Studies-2 (QUADAS-2) tool. STATA SE was used for the meta-analysis of the sensitivity, specificity, positive likelihood ratio and negative likelihood ratio. Results Among a total of 1376 initially identified studies, only 12 articles met the final inclusion criteria. The pooled sensitivity and specificity were 1.00 (95% CI: 0.00–1.00) and 0.71 (95% CI: 0.50–0.78) for HDV total antibodies, 0.96 (95% CI: 0.83–0.99) and 0.98 (95% CI: 0.82–1.00) for anti-HDV IgM and 0.95 (95% CI: 0.86–0.98) and 0.96 (95% CI: 0.67–1.00) for anti-HDV IgG. The pooled sensitivity and specificity for HDV serological tests were 0.99 (95% CI: 0.96–1.00) and 0.90 (95% CI: 0.79–0.96). Conclusions This meta-analysis suggests that serological tests have high diagnostic performance in detecting antibodies against HDV, especially in HDV IgM and IgG. However, this conclusion is based on studies of a limited number and quality, and the development of new diagnostic tools with higher precision and reliability is still necessary.
Do natural processes at the juvenile stage of stand development differentiate the spatial structure of trees in artificially established forest stands?

Abstract Structural diversity is one of the most interesting phenomena that have been studied by forest ecologists and practitioners. Amongst the different characteristics of forest structure, spatial diversity of trees and their attributes seem to be very important The more spatially structured a population is, the higher its diversity in terms of size and species richness. Because most forests in Europe are managed and were artificially established, they are subjected to conversion processes turning them into more complex systems. The approach presented here aims at elucidating whether natural processes, such as self-thinning, can cause the self-differentiation of spatial structure in artificially planted stands. Our analyses focused on untended Scots pine and pedunculate oak stands in the juvenile phase of development and were based on spatially explicit structural indices for positioning and size differentiation (diameter, total height and crown length). The obtained results indicate that live trees were dispersed more or less regularly. Unlike the anglebased index, which mostly indicated randomness in tree location, a distance-based index showed clear regularity. We also found that the distribution of tree attributes auto-correlates to tree location as indicated by significantly tower index values compared to values resulting from random reassignment of the examined attributes. This low degree of spatial differentiation is further confirmed by the distribution of indices in differentiation classes. Our results allow us to conclude that, in the case of light demanding species (pine and oak.), natural processes do not increase spatial diversity of the stand, although, both species showed a certain degree of deviation in this respect.
The mediation effect of social support between stigma and social alienation in patients with stroke

Background Social alienation is prevalent and causes adverse outcomes in stroke. Previous studies have linked stigma with social alienation. However, little is known about the mechanisms behind this relationship. This study explored the mediation effects of social support between stigma and social alienation. Methods A cross-sectional design was used to study 248 patients with stroke admitted to a tertiary rehabilitation hospital in Beijing, China, from December 2022 to July 2023. Patients were assessed using a general information questionnaire, the Stroke Stigma Scale, the Social Support Rating Scale, and the Generalized Social Alienation Scale. The PROCESS macro in SPSS was used to examine the mediation model. Results The results showed that stigma has a negative effect on social support (β = −0.503, p<0.001); stigma has a positive effect on social alienation (β = 0.768, p<0.001). Social support mediated the relationship between stigma and social alienation, with a mediation effect of 0.131 (95%CI: 0.060, 0.214), and indirect effects accounted for 17.06% of the total effect. Conclusion Social support mediated the relationship between stigma and social alienation. These findings suggest that intervention targeting the enhancement of social support may prevent or reduce social alienation among patients with stroke.
Refinement of the crystal structure of zoned philipsbornite– hidalgoite from the Tsumeb mine, Namibia, and hydrogen bonding in the D2+G3+3 (T5+O4)(TO3OH)(OH)6 alunite structures

Abstract The crystal structure of zoned philipsbornite−hidalgoite, hexagonal (rhombohedral), R3̅m, Z = 3: a = 7.1142(4), c = 17.0973(9) Å, V = 749.4(1) Å3, from the Tsumeb mine, Namibia, has been refined to R1 = 1.68% for 301 unique reflections collected on a Bruker D8 three-circle diffractometer equipped with a rotating-anode generator, multilayer optics and an APEX-II CCD detector. Chemical analysis by electron microprobe showed zoned crystals with a rim enriched in S and Fe relative to the core. The core composition is SO3 3.31, As2O5 30.57, Al2O3 23.05, FeO 1.44, PbO 33.94, H2Ocalc 9.58, total 101.79 wt. %, corresponding to Pb2+0.98(Al2.92Fe2+0.13)(AsO4)[(As0.72S0.27)O3.14(OH)0.85](OH)6; and the rim composition is SO3 8.88, As2O5 22.63, Al2O3 22.90, FeO 2.57, PbO 34.91, H2Ocalc 9.27, total 101.16 wt. %, corresponding to Pb2+0.99(Al2.85Fe2+0.23)(AsO4)[(As0.25S0.70)O3.30(OH)0.50](OH)6. Philipsbornite−hidalgoite has the alunite-type structure, sheets of corner-sharing octahedra, decorated on top and bottom by [(As,S)O4] and (AsO3OH) tetrahedra, that are linked into a three-dimensional structure by [12]-coordinated Pb2+ cations and hydrogen bonds. A new hydrogen-bonding scheme for the D2+G3+3 (T5+O4)(TO3OH)(OH)6 minerals is proposed.
Vacuolar proteomic analysis reveals tonoplast transporters for accumulation of citric acid and sugar in citrus fruit

Abstract Vacuole largely dictates the fruit taste and flavor, as most of the sugars and organic acids are stored in the vacuoles of the fruit. However, difficulties associated with vacuole separation severely hinder identification and characterization of vacuolar proteins in fruit species. In this study, we established an effective approach for separating vacuoles and successfully purified vacuolar protein from six types of citrus fruit with varying patterns of sugar and organic acid contents. By using label-free LC–MS/MS proteomic analysis, 1443 core proteins were found to be associated with the essential functions of vacuole in citrus fruit. Correlation analysis of metabolite concentration with proteomic data revealed a transporter system for the accumulation of organic acid and soluble sugars in citrus. Furthermore, we characterized the physiological roles of selected key tonoplast transporters, ABCG15, Dict2.1, TMT2, and STP7 in the accumulation of citric acid and sugars. These findings provide a novel perspective and practical solution for investigating the transporters underlying the formation of citrus taste and flavor.