Miracle-dz/UniFAR-FTUs huggingface dataset:
Role of Endothelial Regeneration and Overloading of Enterocytes with Lipids in Capturing of Lipoproteins by Basement Membrane of Rat Aortic Endothelium

Atherosclerosis is a complex non-monogenic disease related to endothelial damage in elastic-type arteries and incorrect feeding. Here, using cryodamage of endothelial cells (ECs) of rat abdominal aorta, we examined the role of the EC basement membrane (BM) for re-endothelization endothelial regeneration and its ability to capture low density lipoproteins (LDLs). Regeneration of endothelium induced thickening of the ECBM. Secretion of the BM components occurred in the G2-phase. Multiple regenerations, as well as arterial hypertension and aging, also led to the thickening of the BM. Under these conditions, the speed of re-endothelialization increased. The thick BM captured more LDLs. LDLs formed after overloading of rats with lipids acquired higher affinity to the BM, presumably due to the prolonged transport of chylomicrons through neuraminidase-positive endo-lysosomes. These data provide new molecular and cellular mechanisms of atherogenesis.
Oral Administration of Recombinant Lactoferrin-Expressing Probiotics Ameliorates Diet-Induced Lipid Accumulation and Inflammation in Non-Alcoholic Fatty Liver Disease in Mice

We have recently developed probiotics that can express bovine, human, or porcine lactoferrin (LF), and the present study evaluated the effect of these probiotics in improving non-alcoholic fatty liver disease (NAFLD). Three kinds of probiotic supplements, including lactic acid bacteria (LAB), LAB/LF, and inactivated LAB/LF, were prepared. The LAB supplement was prepared from 10 viable LAB without recombinant LF-expression, the LAB/LF supplement was prepared from 10 viable probiotics expressing LF, and the inactivated LAB/LF supplement was prepared from 10 inactivated probiotics expressing LF. A model of obese/NAFLD mice induced by a high-fat diet was established, and the mice were randomly divided into four groups and fed with a placebo, LAB, LAB/LF, or inactivated LAB daily for four weeks via oral gavage. The body weight, food intake, organ weight, biochemistry, and hepatic histopathological alterations and severity scoring were measured. The results revealed that the obese mice fed with any one of the three probiotic mixtures prepared from recombinant probiotics for four weeks exhibited considerably improved hepatic steatosis. These findings confirmed the assumption that specific probiotic strains or LF supplements could help to control NAFLD, as suggested in previous reports. Our data also suggest that the probiotics and LFs in probiotic mixtures contribute differently to improving the efficacy against NAFLD, and the expressed LF content in probiotics may help to boost their efficacy in comparison with the original probiotic mixtures. Moreover, when these LF-expressing probiotics were further inactivated by sonication, they displayed better efficacies than the viable probiotics against NAFLD. This study has provided intriguing data supporting the potential of recombinant probiotics in improving hepatic steatosis.
Factors Affecting Post-Challenge Survival of Flavobacterium psychrophilum in Susceptible Rainbow Trout from the Literature

Infectious bacterial pathogens are a concern for aquaculture as estimates suggest that billions of US dollars are lost annually in aquaculture due to disease. One of the most prevalent salmonid pathogens is the bacterium Flavobacterium psychrophilum that causes bacterial coldwater disease. We reviewed the published F. psychrophilum literature and conducted a Bayesian analysis to examine large-scale patterns in rainbow trout (Oncorhynchus mykiss) mortality associated with laboratory challenge. We incorporated factors that were common across a majority of the laboratory exposure studies and these included bacterial dose, culture time, exposure method, bacterial isolate, experimental duration, and fish weight. The comparison showed that injection as the exposure method produced higher mortality than bath immersion, bacterial isolates differed in their effect on mortality, and bacterial dose has an interactive effect with fish weight and exposure method. Our comparison allows for inference on factors affecting rainbow trout mortality due to exposure to F. psychrophilum and suggests avenues to further optimize research protocols to better reach study goals.
Free-form modelling of galaxy clusters: a Bayesian and data-driven approach

A new method is presented for modelling the physical properties of galaxy clusters. Our technique moves away from the traditional approach of assuming specific parameterised functional forms for the variation of physical quantities within the cluster, and instead allows for a 'free-form' reconstruction, but one for which the level of complexity is determined automatically by the observational data and may depend on position within the cluster. This is achieved by representing each independent cluster property as some interpolating or approximating function that is specified by a set of control points, or 'nodes', for which the number of nodes, together with their positions and amplitudes, are allowed to vary and are inferred in a Bayesian manner from the data. We illustrate our nodal approach in the case of a spherical cluster by modelling the electron pressure profile Pe(r) in analyses both of simulated Sunyaev-Zel'dovich (SZ) data from the Arcminute MicroKelvin Imager (AMI) and of real AMI observations of the cluster MACS J0744+3927 in the CLASH sample. We demonstrate that one may indeed determine the complexity supported by the data in the reconstructed Pe(r), and that one may constrain two very important quantities in such an analysis: the cluster total volume integrated Comptonisation parameter (Ytot) and the extent of the gas distribution in the cluster (rmax). The approach is also well-suited to detecting clusters in blind SZ surveys.
A CENSUS OF MID-INFRARED-SELECTED ACTIVE GALACTIC NUCLEI IN MASSIVE GALAXY CLUSTERS AT 0 ≲ z ≲ 1.3

We conduct a deep mid-infrared (mid-IR) census of nine massive galaxy clusters at (0 < z < 1.3) with a total of ∼1500 spectroscopically confirmed member galaxies using Spitzer/IRAC photometry and established mid-IR color selection techniques. Of the 949 cluster galaxies that are detected in at least three of the four IRAC channels at the ⩾3σ level, we identify 12 that host mid-IR-selected active galactic nuclei (IR-AGNs). To compare the IR-AGNs across our redshift range, we define two complete samples of cluster galaxies: (1) optically selected members with rest-frame VAB magnitude < − 21.5 and (2) mid-IR-selected members brighter than (M*3.6 + 0.5), i.e., essentially a stellar mass cut. In both samples, we measure f IR-AGN ∼ 1% with a strong upper limit of ∼3% at z < 1. This uniformly low IR-AGN fraction at z < 1 is surprising given that the fraction of 24 μm sources in the same galaxy clusters is observed to increase by about a factor of four from z ∼ 0 to z ∼ 1; this indicates that most of the detected 24 μm flux is due to star formation. Only in our single galaxy cluster at z = 1.24 is the IR-AGN fraction measurably higher at ∼15% (all members; ∼70% for late-types only). In agreement with recent studies, we find that the cluster IR-AGNs are predominantly hosted by late-type galaxies with blue optical colors, i.e., members with recent/ongoing star formation. The four brightest IR-AGNs are also X-ray sources; these IR+X-ray AGNs all lie outside the cluster core (Rproj ≳ 0.5 Mpc) and are hosted by highly morphologically disturbed members. Although our sample is limited, our results suggest that f IR-AGN in massive galaxy clusters is not strongly correlated with star formation at z < 1 and that IR-AGNs have a more prominent role at z ≳ 1.
Psittacid alphaherpesvirus 5 infection in Indian ringneck parakeets in southern California

Four Indian ringneck parakeets (Psittacula krameri; syn. ringneck parrots or rose-ringed parakeets) were submitted by 2 private owners for autopsy following a history of dyspnea and death. Gross findings were varied and included thickening of the left caudal thoracic air sac, white spots throughout the liver, mild dilation of the proventriculus, coelomic effusion, splenomegaly, and pulmonary congestion and edema. Microscopically, the submitted parakeets had significant lesions in the lower respiratory tract, including necrotizing bronchitis, parabronchitis, and interstitial pneumonia with numerous syncytia containing eosinophilic intranuclear inclusions. Electron microscopy of the lungs was compatible with a herpesviral infection and Psittacid alphaherpesvirus 5 (PsAHV5) was detected via PCR and sequencing. There has been inconsistent terminology used with Psittacid alphaherpesvirus 3 and PsAHV5; we attempt here to clarify the reported history of these viruses.
Sublingual Immunotherapy for Japanese Cedar Pollinosis: Current Clinical and Research Status

The incidence of Japanese cedar pollinosis is increasing significantly in Japan, and a recent survey suggested that about 40% of the population will develop this disease. However, spontaneous remission is rare. The increased incident rate of Japanese cedar pollinosis is a huge issue in Japan. Allergen immunotherapy is the only fundamental treatment that modifies the natural course of allergic rhinitis and provides long-term remission that cannot be induced by general drug therapy. Sublingual immunotherapy for Japanese cedar pollinosis has been developed and has been covered by health insurance since 2014 in Japan. The indication for children was expanded in 2018. Clinical trials of sublingual immunotherapy for Japanese cedar pollinosis have demonstrated its long-term efficacy and safety. It is recommended for patients who wish to undergo fundamental treatment regardless of the severity of the practical guidelines for the management of allergic rhinitis in Japan. For sublingual immunotherapy, a long-term treatment period of 3 years or longer is recommended to obtain stable therapeutic effects. In recent years, evidence based on basic research and clinical trials has demonstrated sublingual immunotherapy-induced immunological changes and efficacy in patients; however, biomarkers that objectively predict and judge these therapeutic effects need to be established.
Promoting Compassionate Responses to Disclosures of Sexual Violence in University Settings: Exploring the Impact of a Social Marketing Campaign

This study explores a social marketing campaign aimed to promote compassionate responses to disclosures of sexual violence from peers and raise awareness of university-based formal support services. Findings from a survey (n = 189) and follow-up focus groups (n = 11) conducted with university students in Australia indicated that exposure to the campaign may support students’ self-perceived confidence in responding compassionately to disclosures of sexual violence and raise awareness of university-based formal support services. These findings suggest social marketing may be a useful tool to form part of universities’ sexual violence response and prevention strategies. These findings may help inform future university campaigns.
Optical spectral classification of southern ultraluminous infrared galaxies

We present a study of the optical spectral properties of 115 ultraluminous infrared galaxies (ULIRGs) in the southern sky. Using the optical spectra obtained at the Cerro Tololo Inter-American Observatory (CTIO) 4 -m telescope and provided by the Two-degree Field (2dF) Galaxy Redshift Survey and the Six-degree Field (6dF) Galaxy Survey, we measure emission linewidths and fluxes for spectral classification. We determine the spectral types of ULIRGs with Hα measurement using the standard diagnostic diagrams. For ULIRGs without Hα measurement, we determine their spectral types using the plane of flux ratio between [O iii]λ5007 and Hβ versus [O iii] linewidth based on our new empirical criterion. This criterion is efficient to distinguish active galactic nuclei (AGNs) from non-AGN galaxies with completeness and reliability of about 90 per cent. The sample of 115 ULIRGs is found to consist of eight broad-line AGNs, 49 narrow-line AGNs and 58 non-AGNs. The AGN fraction is on average 50 per cent and increases with infrared luminosity and Infrared Astronomical Satellite (IRAS) 25–60 μm colour, consistent with previous studies. The IRAS 25–60 μm colour distributions are significantly different between AGN and non-AGN ULIRGs, while their IRAS 60–100 μm colour distributions are similar.
MHD–KINETIC TRANSITION IN IMBALANCED ALFVÉNIC TURBULENCE

Alfvénic turbulence in space is usually imbalanced: amplitudes of waves propagating parallel and anti-parallel to the mean magnetic field are unequal. It is commonly accepted that the turbulence is driven by (counter-)collisions between these counter-propagating wave fractions. Contrary to this, we found a new ion-scale dynamical range of the turbulence established by (co-)collisions among waves co-propagating in the same direction along . Co-collisions become stronger than counter-collisions and produce steep non-universal spectra above certain wavenumbers dependent on the imbalance. Spectral indexes of the strong turbulence vary around , such that steeper spectra follow larger imbalances. Intermittency steepens the −3 spectra further, up to −3.7. Our theoretical predictions are compatible with steep variable spectra observed in the solar wind at ion kinetic scales, but further verifications are needed by correlating observed spectra with measured imbalances.
SARS-CoV-2 spike conformation determines plasma neutralizing activity elicited by a wide panel of human vaccines

Numerous safe and effective COVID-19 vaccines have been developed worldwide that utilize various delivery technologies and engineering strategies. We show here that vaccines containing prefusion-stabilizing S mutations elicit antibody responses in humans with enhanced recognition of S and the S1 subunit relative to postfusion S, as compared to vaccines lacking these mutations or natural infection. Prefusion S and S1 antibody binding titers positively and equivalently correlated with neutralizing activity and depletion of S1-directed antibodies completely abrogated plasma neutralizing activity. We show that neutralizing activity is almost entirely directed to the S1 subunit and that variant cross-neutralization is mediated solely by RBD-specific antibodies. Our data provide a quantitative framework for guiding future S engineering efforts to develop vaccines with higher resilience to the emergence of variants than current technologies.
Vortex liquid phase in the 
p
-wave ferromagnetic superconductor UCoGe

The upper critical field for H//b of the p-wave ferromagnetic superconductor UCoGe has a particular S-shape, akin to the re-entrant superconducting phase of URhGe. To explore the evolution of the superconducting phase under this transverse magnetic field, we report the thermal conductivity and resistivity measurements, revealing a possible field-induced vortex liquid phase and supporting a field-induced change of the superconducting order parameter.
The global history of reionization

Using a Bayesian framework, we quantify what current observations imply about the history of the epoch of reionisation (EoR). We use a popular, three-parameter EoR model, flexible enough to accommodate a wide range of physically-plausible reionisation histories. We study the impact of various EoR observations: (i) the optical depth to the CMB measured by Planck 2016; (ii) the dark fraction in the Lyman $\alpha$ and $\beta$ forests; (iii) the redshift evolution of galactic Ly$\alpha$ emission (so-called "Ly$\alpha$ fraction"); (iv) the clustering of Ly$\alpha$ emitters; (v) the IGM damping wing imprint in the spectrum of QSO ULASJ1120+0641; (vi) and the patchy kinetic Sunyaev-Zel'dovich signal. Combined, (i) and (ii) already place interesting constraints on the reionisation history, with the epochs corresponding to an average neutral fraction of (75, 50, 25) per cent, constrained at 1$\sigma$ to $z= (9.21\substack{+1.22 -1.15}, 8.14\substack{+1.08 -1.00}, 7.26\substack{+1.13 -0.96})$. Folding-in more model-dependent EoR observations [(iii--vi)], strengthens these constraints by tens of per cent, at the cost of a decrease in the likelihood of the best-fit model, driven mostly by (iii). The tightest constraints come from (v). Unfortunately, no current observational set is sufficient to break degeneracies and constrain the astrophysical EoR parameters. However, model-dependent priors on the EoR parameters themselves can be used to set tight limits by excluding regions of parameter space with strong degeneracies. Motivated by recent observations of $z\sim7$ faint, lensed galaxies, we show how a conservative upper limit on the virial temperature of haloes which host reionising galaxies can constrain the escape fraction of ionising photons to $f_{\rm esc} = 0.14\substack{+0.26 -0.09}$
Intergalactic Lyman continuum photon budget in the past 5 billion years

We constrain the H I photoionization rate $(\Gamma_{\rm HI})$ at $z \lesssim 0.45$ by comparing the flux probability distribution function and power spectrum of the Ly-$\alpha$ forest data along 82 QSO sightlines obtained using Cosmic Origins Spectrograph with models generated from smoothed particle hydrodynamic simulations. We have developed a module named "Code for Ionization and Temperature Evolution (CITE)" for calculating the intergalactic medium (IGM) temperature evolution from high to low redshifts by post-processing the GADGET-2 simulation outputs. Our method, that produces results consistent with other simulations, is computationally less expensive thus allowing us to explore a large parameter space. It also allows rigorous estimation of the error covariance matrix for various statistical quantities of interest. We find that the best-fit $\Gamma_{\rm HI}(z)$ increases with $z$ and follows $(4 \pm 0.1) \times 10^{-14}\:(1+z)^{4.99 \pm 0.12}$ s$^{-1}$. At any given $z$ the typical uncertainties $\Delta \Gamma_{\rm HI} / \Gamma_{\rm HI}$ are $\sim 25$ per cent which contains not only the statistical errors but also those arising from possible degeneracy with the thermal history of the IGM and cosmological parameters and uncertainties in fitting the QSO continuum. These values of $\Gamma_{\rm HI}$ favour the scenario where only QSOs contribute to the ionizing background at $z<2$. Our derived $3\sigma$ upper limit on average escape fraction is $0.008$, consistent with measurements of low-$z$ galaxies.
New supersymmetry-generated complex potentials with real spectra

A new form to construct complex superpotentials that produce real energy spectra in supersymmetric quantum mechanics is presented. This is based on the relation between the nonlinear Ermakov equation and a second order differential equation of the Schrödinger type. The superpotentials so constructed are characterized by the Ermakov parameters in such a way that they are always complex-valued and lead to non-Hermitian Hamiltonians with real spectra, whose eigenfunctions form a bi-orthogonal system. As applications we present new complex supersymmetric partners of the free particle that are   ? > -symmetric and can be either periodic or regular (of the Pöschl–Teller form). A new family of complex oscillators with real frequencies that have the energies of the harmonic oscillator plus an additional real eigenvalue is introduced.
Charge Order and Suppression of Superconductivity in HgBa2CuO4+d at High Pressures

New insight into the superconducting properties of HgBa2CuO4 (Hg-1201) cuprates is provided by combined measurements of electrical resistivity and single crystal X-ray diffraction under pressure. The changes induced by increasing pressure up to 20 GPa in optimally doped single crystals were investigated. The resistivity measurements as a function of temperature show a metallic behavior up to ~10 GPa that gradually passes into an insulating state, typical of charge ordering, which totally suppresses superconductivity above 13 GPa. The changes in resistivity are accompanied by the apparition of sharp Bragg peaks in the X-ray diffraction patterns, indicating that the charge ordering is accompanied by a 3D oxygen ordering. Considering that pressure induces a charge transfer of about 0.02 at 10 GPa, our results are the first observation of charge order competing with superconductivity developed in the overdoped region of the phase diagram of a Hg-based cuprate.
Millihertz quasi-periodic oscillations and broad iron line from LMC X-1

We study the temporal and energy spectral characteristics of the persistent black hole X-ray binary LMC X-1 using two XMM-Newton and a Suzaku observation. We report the discovery of low frequency (~ 26-29 mHz) quasi-periodic oscillations (QPOs). We also report the variablity of the broad iron K-alpha line studied earlier with Suzaku. The QPOs are found to be weak with fractional rms amplitude in the ~ 1-2 % range and quality factor Q~2-10 . They are accompanied by weak red noise or zero-centered Lorentzian components with rms variability at the ~ 1-3 % level. The energy spectra consists of three varying components - multicolour disk blackbody (kT_{in} ~ 0.7-0.9 keV), high energy power-law tail (Gamma ~ 2.4 - 3.3) and a broad iron line at 6.4-6.9 keV. The broad iron line, the QPO and the strong power-law component are not always present. The QPOs and the broad iron line appear to be clearly detected in the presence of a strong power-law component. The broad iron line is found to be weaker when the disk is likely truncated and absent when the power-law component almost vanished. These results suggest that the QPO and the broad iron line together can be used to probe the dynamics of the accretion disk and the corona.
Proximity Effect Induced Electronic Properties of Epitaxial Graphene on Bi2Te2Se

We report that the {\pi}-electrons of graphene can be spin-polarized to create a phase with a significant spin-orbit gap at the Dirac point (DP) using a graphene-interfaced topological insulator hybrid material. We have grown epitaxial Bi2Te2Se (BTS) films on a chemical vapor deposition (CVD) graphene. We observe two linear surface bands both from the CVD graphene notably flattened and BTS coexisting with their DPs separated by 0.53 eV in the photoemission data measured with synchrotron photons. We further demonstrate that the separation between the two DPs, {\Delta}D-D, can be artificially fine-tuned by adjusting the amount of Cs atoms adsorbed on the graphene to a value as small as {\Delta}D-D = 0.12 eV to find any proximity effect induced by the DPs. Our density functional theory calculation shows a spin-orbit gap of ~20 meV in the {\pi}-band enhanced by three orders of magnitude from that of a pristine graphene, and a concomitant phase transition from a semi-metallic to a quantum spin Hall phase when {\Delta}D-D $\leq$ 0.20 eV. We thus present a practical means of spin-polarizing the {\pi}-band of graphene, which can be pivotal to advance the graphene-based spintronics.