Miracle-dz/UniFAR-FTUs huggingface dataset:
Keep Them in the Game: Screening for Cardiovascular Disease and Diabetes in Aging Athletes

Purpose: This observational cross-sectional study of aging athletes aims to (1) compare the prevalence of cardiovascular disease (CVD) and diabetes in aging athletes to the general population, (2) describe anthropometric values of aging athletes, (3) investigate the influence of cardiovascular sport competition on these measures, and (4) address any predictive value of evaluated measures. Methods: Health and sport history, blood pressure, waist circumference (WC), waist-to-hip ratio, and body mass index (BMI) were collected on 2351 aging athletes. Results: Aging athletes showed a significantly lower prevalence of CVD and diabetes than the general population. Athletes demonstrated BMI in the overweight range, WC in a healthy range, and waist-to-hip ratio in a healthy range for women but just over risk thresholds for men. Average blood pressure was near stage 1 hypertension. Waist circumference and waist-to-hip ratio were superior predictors of disease in the population. Cardiovascular athletes showed a lower disease risk and overall superior anthropometric values than other aging athletes. Conclusion: Aging athletes demonstrate a relatively low prevalence of CVD and diabetes despite demonstrating some anthropometric measurements over risk thresholds. Measures of central adiposity seem best for predicting disease in this population.
Outcomes following stereotactic radiosurgery or whole brain radiation therapy by molecular subtype of metastatic breast cancer

Background This study quantified clinical outcomes by molecular subtype of metastatic breast cancer (BC) following whole brain radiation therapy (WBRT) or stereotactic radiosurgery (SRS). Doing so is important for patient counseling and to assess the potential benefit of combining targeted therapy and brain radiotherapy for certain molecular subtypes in ongoing trials. Materials and methods The National Cancer Database was queried for BC (invasive ductal carcinoma) cases receiving brain radiotherapy (divided into WBRT and SRS ). Statistics included multivariable logistic regression to determine factors associated with SRS delivery, Kaplan-Meier analysis to evaluate overall survival (OS), and Cox proportional hazards modeling. Results Of 1,112 patients, 186 (16.7%) received SRS and 926 (83.3%) underwent WBRT. Altogether, 410 (36.9%), 195 (17.5%), 162 (14.6%), and 345 (31.0%) were ER+/HER2−, ER+/HER2+, ER−/HER2+, and ER−/HER2−, respectively. In the respective molecular subtypes, the proportion of subjects who underwent SRS was 13.4%, 19.4%, 24.1%, and 15.7%. Respective OS for WBRT patients were 12.9, 22.8, 10.6, and 5.8 months; corresponding figures for the SRS cohort were 28.3, 40.7, 15.0, and 12.9 months (p < 0.05 for both). When comparing OS between treatment different histologic subtypes, patients with ER−/HER2+ and ER−/HER2− disease had worse OS than patients with ER+/HER2− disease, for both patients treated with SRS and for patients treated with WBRT. Conclusions Molecular subtype may be a useful prognostic marker to quantify survival following SRS/WBRT for metastatic BC. Patients with HER 2-enriched and triple-negative disease had the poorest survival following brain irradiation, lending credence to ongoing studies testing the addition of targeted therapies for these subtypes.
Mental Health, Cognition and Academic Performance in the 1st Year of Elementary Education

Abstract The study investigated 1) relationships and explanatory models of mental health indicators from cognitive abilities and 2) relationships between mental health indicators and academic performance one year later. Participants were 86 children, students of the 1st year of Elementary Education, evaluated in intelligence, inhibitory control (IC) and language. Parents and teachers completed the Strengths and Difficulties Questionnaire (SDQ). One year later, the children were re-evaluated in word recognition (WR) and arithmetic. The IC measures were related and could explain up to 21.9% of the variance in the SDQ indices completed by parents and teachers. The SDQ indices completed by teachers were related to WR and arithmetic performances, predicting up to 16.3% of the variance in school performance measures the following year. There was no IC mediation effect on the models generated. The findings suggest an interaction between specific cognitive skills, mental health indicators and academic performance.
Curcumin inhibits cystogenesis in autosomal dominant polycystic kidney disease cells via altering JAK2/STAT3 activity

Autosomal dominant polycystic kidney disease (ADPKD) arises primarily due to Pkd1 mutations and is characterised by increased kidney epithelial proliferation. The Janus Kinase and Signal Transducers and Activators of Transcription (JAK-STAT) is a proliferation regulating pathway implicated in ADPKD. Curcumin, an anti-inflammatory phytochemical, has been shown to limit murine cystogenesis possibly via JAK-STAT. However, the mechanisms employed by curcumin to inhibit JAK-STAT are uncertain. We treated ADPKD-derived renal epithelial cells with curcumin at different concentrations over 9 days and studied their growth in organotypic cystforming assays. Curcumin potently blocked cystic growth in human and mouse renal epithelial cells without requiring any additional cell types, suggesting a direct effect on kidney epithelial cells. The level of tyrosine phosphorylated-STAT3 was reduced within 1 hour of curcumin treatment in a dose-dependent manner. While total STAT3 protein levels remained unaltered, suggesting that curcumin reduces phosphorylation of STAT3 possibly via JAK2, a tyrosine kinase upstream of STAT3. Mechanistically, curcumin caused JAK2 to move into an insoluble fraction, without causing JAK2 proteosomal-degradation. Instead curcumin led to JAK2 to accumulate into aggresomes, which are known depots for inactivated enzymes. We studied JAK2 expression in kidneys of the Pkd1 mice, which spontaneously develop progressive ADPKD. JAK2 was highly expressed in cyst-lining renal epithelial cells at 5 and 10 weeks of age, suggesting a potential role in ADPKD pathophysiology. Collectively, these data suggest that curcumin reduces STAT3 signalling and cystic growth by inactivating JAK2, thus selective JAK2 inhibition may be of therapeutic benefit in ADPKD.
Linking sea ice deformation to ice thickness redistribution using
high-resolution satellite and airborne observations

Abstract. An unusual, large polynya opened and then closed by freezing and convergence north of the coast of Greenland in late winter 2018. The closing corresponded to a natural, but well-constrained, full-scale ice deformation experiment. We have observed the closing of and deformation within the polynya with satellite synthetic-aperture radar (SAR) imagery, and measured the accumulated effects of dynamic and thermodynamic ice growth 5 with an airborne electromagnetic (AEM) ice thickness survey one month after the closing began. During that time strong ice convergence decreased the area of the former polynya by a factor of 2.5. The AEM survey showed mean and modal thicknesses of the one-month old ice of 1.96 ± 1.5 m and 0.95 m, respectively.We show that this is in close agreement with the modeled thermodynamic growth and with the dynamic thickening expected from the polynya area decrease during that time. In addition,we found characteristic differences in the shapes of ice thickness distributions in different regions of the closing polynya. These closely corresponded to different deformation histories of the surveyed ice that were derived from the high-resolution SAR imagery by drift tracking along Lagrangian backward trajectories. Results show a linear proportionality between convergence and thickness change that agrees well with ice thickness redistribution theory. In addition, the e-folding of the tails of the different ice thickness distributions is proportional to the magnitude of the total deformation experienced by the ice. Lastly, we developed a simple volume-conserving model to derive dynamic ice thickness change from high-resolution SAR deformation tracking. The model has a spatial resolution of 1.4 km and reconstructs thickness profiles in reasonable agreement with the AEM observations. The computed ice thickness distribution resembles main characteristics like mode, e-folding, and width of the observed distribution. This demonstrates that high-resolution SAR deformation observations are capable of producing realistic ice thickness distributions. The MYI surrounding the polynya had a mean and modal total thickness (snow + ice) of 2.1 ± 1.4 m and 2.0 m, respectively. The similar first- and multi-year ice mean thicknesses elude to the large amount of deformation experienced by the closing polynya.
SARS Coronavirus 2, Severe Acute Respiratory Syndrome, and Middle East Respiratory Syndrome in Children: A Review on Epidemiology, Clinical Presentation, and Diagnosis

Context: Coronavirus Disease 2019 (COVID-19) pandemic has caused irreparable damage to society. The pediatric population may be asymptomatic but has positive viral nucleic acid test results and plays an important role in spreading the infection in populations. However, there is a substantial information gap on the epidemiology, pathology, and clinical presentations of COVID-19 in pediatric patients. Evidence Acquisition: English research articles published before April 18, 2020, were reviewed to understand the clinical characteristics of SARS coronavirus 2, Severe Acute Respiratory Syndrome, and Middle East Respiratory Syndrome in children. The WHO (https://www.who. int/) and CDC (Centers for Disease Control and Prevention, https://www.cdc.gov/) websites were also reviewed to find eligible studies, besides articles extracted from PubMed, Scopus, and Google Scholar. Results: In comparison with SARS and MERS, COVID-19 seems to have wider clinical symptoms and routes of transmission. Multisystem inflammatory syndrome is a unique clinical feature of this novel virus. The low prevalence of COVID-19 in children may be due to lower contacts or incomplete identification rather than resistance to the virus. Conclusions: As this virus is novel, we believe that lessons learned from SARS and MERS outbreaks are very valuable in handling the current pandemic. The aim of this paper was to provide the updated summary of clinical manifestation, diagnostic, molecular, and genetic aspects of the novel coronavirus in comparison with SARS and MERS coronaviruses in children.
Attention Induced Trading and Returns: Evidence from Robinhood Users

Consistent with attention-induced trading models’ predictions, we link episodes of intense buying by retail investors at the brokerage Robinhood to future negative returns. Average five-day abnormal returns are -3% (-6%) for the top stocks purchased each day (more extreme herding) by Robinhood users. We find that herding episodes are related to the simplified display of information on the Robinhood app and to established proxies for investor attention. These factors lead to more concentrated trading by Robinhood users that can impact pricing. For example, during Robinhood outages, retail investor volume drops significantly among stocks that are likely to capture investor attention.
Post-emergent herbicidal activity of Eucalyptus globulus Labill. essential oil

espanolLa aparicion de resistencias debido al uso de herbicidas sinteticos, asi como los consiguientes problemas de salud y medioambientales, son factores importantes en la busqueda de alternativas naturales respetuosas con el medio ambiente en el control de malas hierbas. El aceite esencial de Eucalyptus globulus Labill se ha empleado tradicionalmente en problemas respiratorios y como repelente de insectos por su contenido en 1,8-cineol. Se ha determinado la composicion quimica del aceite esencial comercial de E. globulus y su actividad fitotoxica en tres conocidas malas hierbas anuales (Portulaca oleracea L., Echinochloa crus-galli (L) Beau y Lolium multiflorum Lam. ). Se identificaron veintiocho compuestos que representan el 99,83 % de la composicion total de este, mediante cromatografia de gases - espectrometria de masas. Los componentes ma-yoritarios fueron el monoterpeno oxigenado 1,8-cineol (76,43 ± 0,35 %) y el monoterpeno hidro-carbonado α-pineno (14,64 ± 0,27 %). El aceite esencial de E. globulus carece de actividad frente a la germinacion de semillas de las malas hierbas ensayadas, mostrando efecto inhibitorio significativo sobre la elongacion del hipocotilo y radicula de E. crus-galli a la dosis mas alta (1 μL/mL) empleada y sobre el crecimiento de la radicula de L. multiflorum a todas las concentraciones (0,125, 0,25, 0,50 y 1 μL/mL) aplicadas. El aceite esencial de E. globulus puede utilizarse en el manejo de E. crus-galli debido a su actividad herbicida postemergente. EnglishWeed resistances to synthetic herbicides, as well as consequent health and environmental problems, are important items to find more eco-friendly natural alternatives to weed control. Eucalyptus globulus Labill. essential oil has been traditionally used against respiratory troubles as well as an insect repellent due to 1,8-cineole content. Chemical composition of commercial E. globulus essential oil and its phytotoxic activity against three common annual weeds (Portulaca oleracea L., Echinochloa crus-galli (L) Beau. and Lolium multiflorum Lam. ) has been studied. 28 compounds reaching 99.83% of the total essential oil were identified by gas chromatography-mass spectrometry analysis. The oxygenated monoterpene 1,8-cineole (76.43±0.35%), followed by the monoterpene hydrocarbon α-pinene (14.64±0.27%) were the main compounds. E. globulus essential oil lacks of phytotoxicity against the seed germination of the tested weed, showing significant effect on hypocotyl and radicle elongation of E. crus-galli at the highest dose (1 μL/mL) assayed and radicle inhibitory effects at all concentrations applied (0.125, 0.25, 0.50 and 1 μL/mL) against L. multiflorum. E. globulus essential oil could be used in the management of E. crus-galli due to its post-emergent herbicidal activity.
China A-Shares: Strategic Allocation to Market and Factor Premiums

The authors investigate the added value of strategically allocating to the Chinese A-shares equity market. Their results indicate a positive contribution to a portfolio that only considers traditional developed and emerging equity markets and bonds. The authors find that a diversified A-shares portfolio based on value, quality, and momentum factors exhibits significantly better risk-adjusted performance than the passive A-shares market portfolio. Consequently, allocating to Chinese A-share factor premiums significantly improves the efficient frontier. The conclusions remain similar when incorporating conservative estimates of trading costs or when constructing value-weighted portfolios, which represent more realistic investor returns. TOPICS: Fundamental equity analysis, emerging markets, analysis of individual factors/risk premia, portfolio construction Key Findings ▪ Investors need to decide how much to allocate to the China A-share market now that the market is opening up. ▪ We find that a diversified A-shares factor portfolio based on value, quality, and momentum factors exhibits significantly better risk-adjusted performance than a passive A-shares market portfolio. ▪ Benefits from a factor portfolio in China A-shares remain when incorporating conservative estimates of trading costs, which are relevant in presenting realistic investor returns.
Evaluation of the Self-regulated Learning Model in High Schools: A Systematic Literature Review

Self-regulated learning (SRL) is used to learn things that affect student learning and learning outcomes. This research type is review research, which critically examines and sees the application of the SRL model in Indonesia. The criteria taken in this review research are learning models that have a theoretical and practical foundation. The learning models analyzed include learning models from Boekaerts; Winne; Zimmerman; Efklides; Hadwin, Järvelä and Miller; and Pintrich because it was used as a basis for various SRL studies. Each learning model is explored in detail, including a description of the model, a practical foundation, and instruments built on the model. After that, the learning model is compared with a number of aspects in each phase, so a newer and simpler learning model synthesis appears. The empirical evidence from the SRL meta-analysis was raised regarding the evaluation of the model. The SRL model can improve students' SRL skills, especially students who are still dependent on the teacher's role. Therefore, it is necessary to categorize students before applying the SRL development model consisting of goals, strategies, and reflections. Teachers should have various lists of SRL models, so they can adjust their interventions to improve these skills more effectively.
Role of training & development on employee retention and organizational commitment in the banking sector of Pakistan

The value of human capital can easily be increased with the help of training & development because investment made on personnel is very helpful for the success of the firms in the current competitive era to increase retention and commitment level of staff. The major objective of this study is to examine the role of training & development on employee retention and organizational commitment in the banking sector of Pakistan. The population of the study consists of major eight banks of Pakistan including Islamic, foreign, public and private banks. The sequential exploratory design was followed where qualitative and quantitative data collection methods were used. Purposive sampling was used for the interview while for questionnaire multistage sampling was used. The finding of the study clearly indicates that training & developments have significant affiliation and effect on employee retention and commitment. The training & development play a very vital role in employee career growth, compensation, skills enhancement and capacity building to provide quality services to the clients to achieve organizational objectives.
DUX is a non-essential synchronizer of zygotic genome activation

ABSTRACT Some of the earliest transcripts produced in fertilized human and mouse oocytes code for DUX, a double homeodomain protein that promotes embryonic genome activation (EGA). Deleting Dux by genome editing at the one- to two-cell stage in the mouse impairs EGA and blastocyst maturation. Here, we demonstrate that mice carrying homozygous Dux deletions display markedly reduced expression of DUX target genes and defects in both pre- and post-implantation development, with, notably, a disruption of the pace of the first few cell divisions and significant rates of late embryonic mortality. However, some Dux−/− embryos give rise to viable pups, indicating that DUX is important but not strictly essential for embryogenesis. Summary: Murine DUX regulates transcription in the first embryonic cell divisions but is not strictly essential for embryogenesis.
HEMATOLOGICAL FINDINGS AND COMPLICATIONS IN COVID 19 PATIENTS: A REVIEW.

COVID-19 is a systemic infection with a significant impact on the hematopoietic system and hemostasis. Lymphopenia may be considered as a cardinal laboratory finding, with prognostic potential. Neutrophil/lymphocyte ratio and peak platelet/lymphocyte ratio may also have prognostic value in determining severe cases. During the disease course, longitudinal evaluation of lymphocyte count dynamics and inflammatory indices, including LDH, CRP and IL-6 may help to identify cases with dismal prognosis and prompt intervention in order to improve outcomes. Biomarkers, such high serum procalcitonin and ferritin have also emerged as poor prognostic factors. Furthermore, blood hypercoagulability is common among hospitalized COVID-19 patients. Elevated D-Dimer levels are consistently reported, whereas their gradual increase during disease course is particularly associated with disease worsening. Other coagulation abnormalities such as PT and aPTT prolongation, fibrin degradation products increase, with severe thrombocytopenia lead to life-threatening Disseminated intravascular coagulation (DIC) which necessitates continuous vigilance and prompt intervention. COVID-19 infected patients whatever hospitalized or ambulatory are at high risk for VTE and an early and prolonged pharmacological thromboprophylaxis with low molecular weight heparin is highly recommended. Last but not least, the need for assuring blood donations during the pandemic is also of indispensable value.
Suppression of long non-coding RNA H19 inhibits proliferation, cell migration and invasion in human cervical cancer cells

Purpose : To determine the expression profile of lncRNA H19 in different cervical cancers, and to decipher its function in the growth and metastasis of cervical cancer. Methods : The analysis LncRNA H19 expression was performed using quantitative real time polymerase chain reaction (qRT-PCR). Cell counting kit 8 (CCK8) assay was used to assess the viability of the cells. The cells were transfected with Si-H19 using Lipofectamine 2000 and the metastasis of cells was determined by cell migration and invasion assay. Immunoblotting was used to evaluate the protein expression. Results : The lncRNA H19 expression was considerably enhanced in cervical cancer cells, and was about 2.6 to 5.3 times more in cervical cancer cells relative to non-cancer cells. Inhibition of lncRNA caused significant reduction in cervical cancer cell growth in a time-dependent manner. In addition while silencing of lncRNA inhibited the metastasis of HeLa cells. Cell migration and invasion was about 26 % in Si-H19 transfected cervical cancer cells, relative to 65 % in Si-NC cervical HeLa cells. Similarly, cell invasion was 45 % in Si-H19 cervical HeLa cells relative to the negative control (Si-NC). Inhibition of HeLa cell metastasis was also concomitant with decline of metalloproteinases (MMP)-2 and 9 expression. Conclusion : lncRNA regulates the growth and metastasis of cervical cancer cells. Thus, IncRNA may be an important therapeutic agent for cervical cancer. Keywords : Cervical cancer, lncRNA, Proliferation, Invasion
Elaborating Motive and Psychological Impact of Sharenting in Millennial Parents

The phenomenon of parental care shared through social media (sharenting) is increasingly widespread. This research aimed to elaborate on the motives, strategies, and psychological effects of sharenting by millennial parents. This research is qualitative research with a phenomenological approach. The subjects are millennial parents who have a habit of sharing parenting on social media and are members of the professional community. Determination of the sample uses purposive sampling, so that as many as ten people consisted of five females and five males. Interviews, observations, and documentation are the methods used in data collection. Data were analyzed using reduction techniques, data presentation, and verification. The results showed that the motive of sharenting parents is to receive affirmation and social support, demonstrate the ability to care for children, social participation, and documentation. Millennial parents with a peer-oriented communication model do Sharenting. Sharenting for millennial parents has both positive and negative impacts, namely by providing new information and knowledge, making new friends, and support. The negative effects include feeling insecure, comparing her child with someone else's child, causing animosity and dissent. Thus, it can be concluded that sharenting by millennial parents is carried out with a variety of motives, carried out with a peer approach strategy, and has both positive and negative impacts at the same time. The implication is that millennial parents are more knowledgeable about parenting, understand good sharenting, and are psychologically trained in responding to netizens for their sharenting.