Miracle-dz/UniFAR-FTUs huggingface dataset:
stratification in pediatric acute lymphoblastic leukemia A novel integrated cytogenetic and genomic classification refines risk

http://www.bloodjournal. org/content/124/9/1434.full. html Updated information and services can be found at: (364 articles) Pediatric Hematology (1858 articles) Lymphoid Neoplasia (2814 articles) Free Research Articles (3965 articles) Clinical Trials and Observations Articles on similar topics can be found in the following Blood collections http://www.bloodjournal. org/site/misc/rights.xhtml#repub_requests Information about reproducing this article in parts or in its entirety may be found online at: http://www.bloodjournal. org/site/misc/rights.xhtml#reprints Information about ordering reprints may be found online at: http://www.bloodjournal. org/site/subscriptions/index.xhtml Information about subscriptions and ASH membership may be found online at:
Clinical observation of Baisong tablets for depression

Objective To compare the effect and security of compound Baisong tablets and Fluoxetine in treating depression. Methods 59 patients with depression were randomly divided into two groups and treated with Baisong tablets for 29 patients in group A,and Fluoxetine capsule for 30 patients in group B respectively. The western medicinal clinical efficacy and side effects were evaluated with Hamilton's depression scale(HAMD) and treatment emergent symptom scale(TESS) respectively,and the Chinese medicine efficacy were evaluated with an emotion rating scale for Ganzangxiang(ERSG) of traditional Chinese medicine(TCM) after 2,4 and 6 weeks treatment respectively. Results The scores of HAMD between the two groups decrease notably after ending the treatment(P0.01). The total efficient of group A was 68.9%,while that of group B was 70.0%,the effects and side effects between the two groups was not differences. Conlusions Baisong tablets is a safe and effective in treating depression.
A Comparative Assessment of Random Forest and k-Nearest Neighbor Classifiers for Gully Erosion Susceptibility Mapping

This research was conducted to determine which areas in the Robat Turk watershed in Iran are sensitive to gully erosion, and to define the relationship between gully erosion and geo-environmental factors by two data mining techniques, namely, Random Forest (RF) and k-Nearest Neighbors (KNN). First, 242 gully locations we determined in field surveys and mapped in ArcGIS software. Then, twelve gully-related conditioning factors were selected. Our results showed that, for both the RF and KNN models, altitude, distance to roads, and distance from the river had the highest influence upon gully erosion sensitivity. We assessed the gully erosion susceptibility maps using the Receiver Operating Characteristic (ROC) curve. Validation results showed that the RF and KNN models had Area Under the Curve (AUC) 87.4 and 80.9%, respectively. As a result, the RF method has better performance compared with the KNN method for mapping gully erosion susceptibility. Rainfall, altitude, and distance from a river were identified as the most important factors affecting gully erosion in this area. The methodology used in this research is transferable to other regions to determine which areas are prone to gully erosion and to explicitly delineate high-risk zones within these areas.
EFFECT OF IRRIGATION LEVELS AND SOME TREATMENTS TO REDUCE WATER LOSSES ON THE GROWTH AND YIELD OF TOMATO PLANTS GROWN UNDER NORTH SINAI CONDITIONS

The experiment was conducted during the two successive seasons of 2013 and 2014 at the Agriculture Research Station, in ElArish, North Sinai Governorate, Egypt. Tomato "GS12" hybrid was used in the experiment to study the effect of three water irrigation levels ,. i.e. 100 %, 75 % and 50 % from water requirements of tomato plants under foliar spray with two materials, i.e Dodouxil Benzene Sulphonate "DBS" and Potassium silicate "PS" at two rates 2 and 6 cm/liter on the growth, fruit yield and its quality as well as some water irrigation relationship. Split plot design was used in the experiment. The results showed that, irrigation at the level 100% from tomato requirements with foliar spray by any one of the materials used, i.e. (DBS) or (PS) at the concentration of 6 cm/liter then the concentration of 2 cm/liter recorded the high values of growth parameters, i.e. dry weight of tomato plant organs (roots, leaves and stem). The superior total yield was obtained from the same treatment. The same treatment hassend also, physical and chemical fruit quality. While irrigation tomato plants with 75% from its requirement led to reduction in fruit yield by 25% but in the same time saved 33.6% from water irrigation, moreover irrigation tomato plants with 50% levels saved about 43% from water irrigation and induced 50%reduction from tomato yield. Foliar spray with potassium silicate or Dodouxil Benzene Sulphonate showed significant values in tomato growth, fruit yield and its quality and increased the water use efficiency of tomato plants grown under the condition of North Sinai.
Improved target illumination at Ludvika mines of Sweden through seismic‐interferometric surface‐wave suppression

In mineral exploration, new methods to improve the delineation of ore deposits at depth are in demand. For this purpose, increasing the signal‐to‐noise ratio through suitable data processing is an important requirement. Seismic reflection methods have proven to be useful to image mineral deposits. However, in most hard rock environments, surface waves constitute the most undesirable source‐generated or ambient noise in the data that, especially given their typical broadband nature, often mask the events of interest like body‐wave reflections and diffractions. In this study, we show the efficacy of a two‐step procedure to suppress surface waves in an active‐source reflection seismic dataset acquired in the Ludvika mining area of Sweden. First, we use seismic interferometry to estimate the surface‐wave energy between receivers, given that they are the most energetic arrivals in the dataset. Second, we adaptively subtract the retrieved surface waves from the original shot gathers, checking the quality of the unveiled reflections. We see that several reflections, judged to be from the mineralization zone, are enhanced and better visualized after this two‐step procedure. Our comparison with results from frequency‐wavenumber filtering verifies the effectiveness of our scheme, since the presence of linear artefacts is reduced. The results are encouraging, as they open up new possibilities for denoising hard rock seismic data and, in particular, for imaging of deep mineral deposits using seismic reflections. This approach is purely data driven and does not require significant judgment on the dip and frequency content of present surface waves, which often vary from place to place.
Spatial and Temporal Trends in Diurnal Temperature and Precipitation Extremes in North Central Nigeria

Global warming and changes in precipitation patterns are among the major effects of climate change. In this study, the long-term variability in ambient surface temperature and precipitation were evaluated in the north central region of Nigeria (Abuja, Kogi, Kwara, Niger, and Plateau) using meteorological observations obtained from 1975 to 2008. Daily precipitation data from synoptic weather stations were carefully quality-controlled using the RClimdex 1.1 developed by Expert Team on Climate Change Detection, Monitoring and Indices (ETCCDMI). The quality-controlled dataset were homogenized using RHtestsV4 and the detected change points were adjusted. Results showed a decrease in cool nights and cool days (TN10P, TX10P), and increasing trend in warm nights and days (TN90P, TX90P). The trend in rainfall is variable compared to changes in temperature. The precipitation indices indicated increasing trend in total annual precipitation (PRCPTOT), and a significant decrease in the number of consecutive wet days (CWD) in this region. In general, regional changes in climate temperature and precipitation extremes were significant (p < 0.05) and could result in serious climate induced effects.
Morphological Differences between Single and Multiple Unruptured Aneurysms

The natural history and risk of rupture in multiple unruptured aneurysms is not clearly known. Various Morphometric indices have been proposed to correlate with risk of rupture of intracranial aneurysms. The present study aims to characterize and compare the morphology of patients with unruptured single and multiple aneurysms and correlate the results with rupture risk reported in previous studies. All patients with unruptured single and multiple aneurysms who presented to the hospital from 2009 to 2012 and who had complete 3D digital subtraction angiographic studies were included in the study. Their angiograms were analyzed for aneurysm height, width, and neck width and parent artery diameter. Aspect ratio, bottleneck ratio, height to width ratio and size ratio (SR) of single and multiple aneurysms were compared. 30 patients with single aneurysms and 18 patients with multiple (38) aneurysms were included in the study. Multiple aneurysms had a significantly smaller height and size ratios when compared to single aneurysms. There was no difference in age, gender, history of smoking and hypertension, aneurysm width, neck width, parent artery diameter, aspect ratio, bottle neck ratio and height to width ratio in both the groups. Multiple aneurysms have a lower size ratio than single aneurysms which may translate to a lower rupture risk per aneurysm. However, when patients with multiple aneurysms are considered, the cumulative risk of rupture should be taken into consideration.
Scale matters: The influence of structural inheritance on fracture patterns

Abstract Fracture systems are often geometrically invariant across a range of scales, but the impact of structural inheritance on this relationship is poorly understood. This paper shows how fracture orientations in sedimentary rocks vary at different scales when influenced by pre-rift basement structures. We use high-resolution unmanned aerial vehicle (UAV) orthophotos to map folds and fractures in the basement and cover rocks of the Gippsland Basin, southeast Australia. Outcrop-scale observations are compared with >1 km long faults previously interpreted from potential field data. We use length-coloured rose diagrams of fracture traces to compare trends in fracture orientations. Early Cretaceous syn-rift normal faults exhibit the same ENE-WSW trend at basin (>1 km) and outcrop (meters) scales. Pervasive outcrop-scale, subvertical, NNW-SSE striking joints record a subsequent regional shortening event, but at the basin scale this is only expressed as reverse reactivated ENE-WSW striking faults. Thus, fabrics and/or faults in the underlying basement exert significant control on the orientation of basin-scale fractures in the cover but appear to have limited influence on outcrop-scale fracture orientations. Our observations show that fracture systems influenced by structural inheritance are not scale-invariant, and that a proper understanding of structural architecture can only be achieved by analysing data that span multiple scales.
Carboniferous orthocerid-like coleoid Mitorthoceras with unique shell structure (new order Tuborthocerida, Coleoidea, Cephalopoda); comparison with bactritid-like coleoid Shimanskya

ABSTRACT The Carboniferous genus Mitorthoceras from USA, previously assigned to orthocerids, is here restudied and assigned to the new coleoid order Tuborthocerida. Mitorthoceras has several orthocerid characteristics: longiconic shell with long body chamber; central or subcentral siphuncle containing endosiphuncular deposits; and a tubular, uni-layered connecting ring probably consisting of mixed calcareous and chitinous elements. Coleoid characteristics are: shell wall rich in a chitinous material, and lack of a nacreous layer. Characteristic for the new order is the unique structure of the outer layer of the shell wall; this layer is composed of numerous, narrow, transverse furrows, separated by distally expanding ridges and closed from the exterior by thin calcareous layers, transforming the furrows into tube-like structures. The apical end of the shell forms an acute tip. A similar tube-like furrow-layer probably occurs within the shell wall of the bactritoid-like coleoid Shimanskya that has a smooth shell surface.
Macroclimate and local hydrological regime as drivers of fen vegetation patterns in Tierra del Fuego (Argentina)

In southern South America, a sharp macroclimatic gradient is found, triggered by the Pacific oceanic influence through the Andes. Mires are substantial landscape units along the gradient, where they play varying roles through the area and include varying plant communities. In this study, we analysed the relationship between vegetation and main abiotic factors in the minerotrophic mires (fens) at two different scales.
Therapeutic Observation on Acupoint Thread Embedding plus Auricular Point Sticking for Chronic Pelvic Pain after Acute Pelvic Infection

Objective To observe the clinical efficacy of acupoint thread embedding plus auricular point sticking in treating chronic pelvic pain after acute pelvic infection. Method Totally 160 patients with chronic pelvic pain after acute pelvic infection were randomized into a treatment group of 100 cases and a control group of 60 cases. The treatment group was intervened by acupoint thread embedding plus auricular point sticking, while the control group was by medication. The clinical efficacies were compared between the two groups. Result The total effective rate was 93.0% in the treatment group versus 75.0% in the control group, and the difference was statistically significant(P0.05). Conclusion Acupoint thread embedding plus auricular point sticking is an effective method in treating chronic pelvic pain after acute pelvic infection.
Factors Affecting Black Copreneurial Businesses Performance: Western Cape Experience, South Africa

This study investigated the factors affecting black copreneurial businesses performance in the Western Cape, South Africa. The primary objective of this study is to identify the factors affecting black copreneurial businesses performance in the Western Cape. This study adopted a quantitative research method. The data collection instrument selected for this study was a questionnaire involving one hundred and nineteen (119) subjects. The findings of this study revealed that black copreneurial businesses experience internal and external factors in the Western Cape. The recommendation explainsthe necessary measures that needs to be taken, regarding the addressing of both internal and external factors affecting black copreneurial businesses performance in the Western Cape. The implications of this study are to provide information to the policy makers, to investors and to big companies that are registered on the Johannesburg Stock Exchange to support black copreneurial businesses in South Africa.
Lime movement through highly weathered soil profiles

Applying lime is a fundamental practice for abating acidity in highly weathered soil, but better management strategies for no-till systems are needed to prevent surface pH elevation with little to no subsurface effects. This study was conducted to quantify chemical changes within the soil profile in response to lime and straw applications under both greenhouse and field conditions. Four controlled environment experiments (soil columns) and one field study were conducted on soils classified as Rhodic Hapludox and Rhodic Eutrodox. The soil column experiments evaluated four lime rates (0, 3.9, 7.8, or 15.6 Mg ha−1) and four straw rates (0, 4, 12 and 16 Mg ha−1) either individually or in combination. Lime treatments were surface applied or incorporated in the top 5-cm, while straw treatments were incorporated in the top 5-cm. In the field, lime rates of 0, 8.3 and 33.2 Mg ha−1 were incorporated into the 0 to 10-cm depth in both a soybean [Glycine max] monoculture and diversified cropping system with white oat (Avena sativa), soybean, black oats (Avena strigosa), corn (Zea mays) and wheat (Triticum aestivum). Both field and soil columns studies showed minimal lime movement into the soil profile with chemical changes being limited to 2.5-cm below where it was applied or incorporated regardless of cropping system. Surface application of high lime rates promoted chemical stratification resulting in dramatic increases in topsoil pH and exchangeable Ca and Mg levels with minimal mitigation of subsurface soil acidity. Other studies also suggest that lime movement into the soil profile can vary depending on the experimental condition. Therefore, additional investigations across a wider geographic area, greater range of weather and climatic conditions, methods and rates of lime application need to be conducted to improve lime recommendation for high weathered soil managed using no-till practices.
Relationship between UGT1A1 gene polymorphisms and toxicity/efficacy of irinotecan-based chemotherapy in metastatic colorectal cancer

AIM: To investigate the correlation of UGT1A1*28 and UGT1A1*6 gene polymorphisms with irinotecan-associated adverse events and efficacy in the patients with metastatic colorectal cancer(mCRC) treated with irinotecan-based chemotherapy.METHODS: Analysis of UGT1A1*28 and UGT1A1*6 gene polymorphisms was performed in 207 gastrointestinal cancer patients admitted to our hospital from April 2010 to March 2012 by amplifying the gene fragments using PCR and direct sequencing.Fifty six cases with mCRC treated with irinotecan were chosen to observe the adverse events and efficacy during chemotherapy,and the time to progression(TTP) was also recorded.The incidence of different genotypes was compared.RESULTS: The distribution of the genotypes in 207 gastrointestinal cancer patients was as follows: UGT1A1*28 wild-type(WT) genotype TA6/6(164,79.2%),heterozygous genotype TA6/7(41,19.8%),and homozygous genotype TA7/7(2,1.0%);UGT1A1*6 WT genotype G/G(154,74.4%),heterozygous genotype G/A(51,24.6%),and homozygous genotype A/A(2,1.0%). In the 56 mCRC cases,the incidence of grade 3 and 4 delayed diarrhea and neutropenia in the patients carrying UGT1A1*6(G/A and A/A) was higher than that in the WT genotype(6/6)(38.9% vs 7.9%,61.1% vs 29.0%,both P0.05). The incidence of grade 3 and 4 thrombocytopenia in the patients carrying UGT1A1*28(TA6/7 and TA7/7) was higher than that in the WT genotype(TA6/6)(33.3% vs 2.1%,P0.05). No significant difference of TTP and chemotherapeutic effect was observed between different genotypes.CONCLUSION: The UGT1A1*6(G/A and A/A) genotypes increase the risk of grade 3 and 4 delayed diarrhea and neutropenia,and the UGT1A1*28(TA6/7 and TA7/7) genotypes increase the risk of grade 3 and 4 thrombocytopenia in mCRC patients treated with irinotecan-based chemotherapy.
A Regularization Approach to Improve the Sequential Calibration of a Semidistributed Hydrological Model

In semidistributed hydrological modeling, sequential calibration usually refers to the calibration of a model by considering not only the flows observed at the outlet of a catchment but also the different gauging points inside the catchment from upstream to downstream. While sequential calibration aims to optimize the performance at these interior gauged points, we show that it generally fails to improve performance at ungauged points. In this paper, we propose a regularization approach for the sequential calibration of semidistributed hydrological models. It consists in adding a priori information on optimal parameter sets for each modeling unit of the semidistributed model. Calibration iterations are then performed by jointly maximizing simulation performance and minimizing drifts from the a priori parameter sets. The combination of these two sources of information is handled by a parameter k to which the method is quite sensitive. The method is applied to 1,305 catchments in France over 30 years. The leave‐one‐out validation shows that, at locations considered as ungauged, model simulations are significantly improved (over all the catchments, the median KGE criterion is increased from 0.75 to 0.83 and the first quartile from 0.35 to 0.66), while model performance at gauged points is not significantly impacted by the use of the regularization approach. Small catchments benefit most from this calibration strategy. These performances are, however, very similar to the performances obtained with a lumped model based on similar conceptualization.
The Ravenscar Group: A coeval analogue for the Middle Jurassic reservoirs of the North Sea and offshore Mid-Norway

A palynostratigraphical study of the Middle Jurassic Ravenscar Group, Cleveland Basin, northern England involving the integration of miospore and microplankton data with sedimentary facies data has resulted in improvements in the stratigraphical resolution of offshore hydrocarbon-bearing strata in the North Viking Graben and MidNorway. The Dogger Formation is of ‘earliest’ Aalenian age and is correlative with the uppermost Dunlin Group, Drake Formation and Båt Group, Ror Formation. The overlying Aalenian Saltwick and Eller Beck formations correlate with the Brent Group, Broom–Rannoch–Etive–Ness and the Fangst Group, Ile–Not–‘lower’ Garn genetic packages. The Cloughton Formation is either unrepresented or condensed in the Brent Province and Mid-Norway due to a regional unconformity, which truncates lower Bajocian sediments. The Scarborough Formation is of ‘latest’ early to ‘earliest’ late Bajocian age and correlative with the older part of the Tarbert–Heather and the ‘upper’ Garn–Melke genetic packages. These interpretations contrast markedly with the majority of those published. From: POWELL, A. J. & RIDING, J. B. (eds) 2005. Recent Developments in Applied Biostratigraphy. The Micropalaeontological Society, Special Publications, 43–53. 1747-602X/$15.00 © The Micropalaeontological Society 2005. TMS-01 04 Butler (to_d) 14/10/05 10:42 am Page 43
Response of the Earth’s equatorial ionosphere during the severe G4-class geomagnetic storm of 8th September 2017

Equatorial and low latitude ionospheric response of the 8th September 2017 severe G4-class geomagnetic storm is investigated using the total electron content (TEC) data from a longitudinal chain of global positioning system (GPS) receivers over Asian, African and American sectors. During the main phase, a positive storm effect is observed over Asian sector, a complete negative storm effect over African sector and both are observed over American sector. A sharp increase in peak TEC is observed over the complete longitudinal chain during the recovery phase. The results show the decisive contribution of prompt penetration electric fields (PPEFs) and disturbance dynamo electric fields (DDEFs), storm time disturbed meridional (equatorward) wind as well as the neutral compositional changes over equatorial and low latitudes in the observed ionospheric storm effects.