Miracle-dz/UniFAR-FTUs huggingface dataset:
Rolling regression technique and cross-sectional regression: A tool to analyze Capital Asset Pricing Model

The Capital Asset Pricing Model (henceforth, CAPM) is considered an extensively used technique to approximate asset pricing in the field of finance. The CAPM holds the power to explicate stock movements by means of its sole factor that is beta co-efficient. This study focuses on the application of rolling regression and cross-sectional regression techniques on Indian BSE 30 stocks. The study examines the risk-return analysis by using this modern technique. The applicability of these techniques is being viewed in changing business environments. These techniques help to find the effect of selected variables on average stock returns. A rolling regression study rolls the data for changing the windows for every 3-month period for three years. The study modifies the model with and without intercept values. This has been applied to the monthly prices of 30 BSE stocks. The study period is from January 2009 to December 2018. The study revealed that beta is a good predictor for analyzing stock returns, but not the intercept values in the developed model. On the other hand, applying cross-section regression accepts the null hypothesis. α, β, β2 ≠ 0. Therefore, a researcher is faced with the task of finding limitations of each methodology and bringing the best output in the model.
RADIATION DOSE SURVEY IN CONVENTIONAL PEDIATRIC RADIOLOGY

A survey of some conventional radiographic techniques, Entrance Surface Dose (ESD) and Effective Dose (ED) for pediatrics has been carried out for 811 patients undergoing five different examinations for mobile and conventional (fixed) X ray equipment. For the fixed equipment, the examinations were: abdomen, chest, cervical spine, skull and lumbar spine, for different projections AP, PA and LAT in a total of 432 patients. For the mobile equipment, a similar study was performed for 379 patients and for two examinations: abdomen and chest for the AP projection only. The pediatric hospital was the Instituto Fernandes Figu eira (IFF) from FIOCRUZ (Brazil). For each examination, 4 different age groups 0-1, 1-5, 5-10 and 10-15 years were studied for both types of equipments. R esults can be compared for abdomen AP and chest AP only, because were the only kind of examinations performed with both types of equipment. The mean ESD (μGy) and ED (μSv) were calculated using the DoseCal software. For chest examination in AP the ESD for fixed and mobile X ray equipment for the 0-1 age group were 67 μGy and 39 μGy respectively. For abdomen AP , results were: 242 μGy for fixed and 57 μGy for mobile equipment. Similarly, the ED values for different types of equipment for chest AP were 12 μSv (fixed) and 8μSv (mobile). For abdomen, results were 53 μSv and 13 μSv (fixed and mobile), respectively. It can be seen that all resu lts for the fixed equipment are systematically higher.
Consistent model for short-channel nMOSFET after hard gate oxide breakdown

Dissimilar post-hard-breakdown nMOSFET characteristics are consistently explained by the location of a constant-size breakdown path. Device simulations with the breakdown path modeled as a narrow inclusion of highly doped n-type silicon well reproduce all postbreakdown nFET characteristics, including the substrate current behavior, for both gate-to-substrate and gate-to-extension breakdowns. An equivalent circuit describing the gate current in an nFET after hard gate-oxide breakdown is proposed.
PROFESIONALITAS GURU DALAM MENYUSUN RENCANA PELAKSANAAN PEMBELAJARAN (RPP) PADA SEKOLAH DASAR NEGERI NO. 76/IX DESA MENDALO DARAT KEC. JALUKO KAB. MUARO JAMBI

Penelitian ini berlatar belakang bahwa profesionalitas para guru SD No. 76/IX Desa Mendalo Darat Kec. Jaluko Kab. Muaro Jambi dalam menyusun RPP untuk kondisi saat ini boleh dikatakan masih perlu peningkatan. Yang mana sebagian dari guru masih ditemukan tidak memiliki RPP yang standby e. Rumusan penelitian ini adalah: Bagaimana pemahaman guru Sekolah Dasar Negeri No.76/IX Desa Mendalo Darat Kec.Jaluko Kab. Muaro Jambi tentang rencana pelaksanaan pembelajaran (RPP)? , 2). Bagaimana guru Sekolah Dasar Negeri No. 76/IX Desa Mendalo Darat Kec. Jaluko Kab. Muaro Jambi menyusun rencana pelaksanaan pembelajaran (RPP)? , 3). Apa saja faktor penghambat bagi guru Sekolah Dasar Negeri No. 76/IX Desa Mendalo Darat Kec. JalukoKab. Muaro Jambi dalam menyusun rencana pelaksanaan pembelajaran (RPP)? , Penelitian ini dilakukan di SD No. 76/IX Desa Mendalo Darat Kec. Jaluko Kab. Muaro Jambi pada tahun 2014. Untuk mengecek validitas data maka penulis melakukan ketekunan pengamatan, triangulasi, membercheck, audit trail. Hasil penelitian ini menunjukkan bahwa: 1) Pemahaman guru SD No. 76/IX Desa Mendalo Darat Kecamatan Jaluko Kabupaten Muaro Jambi tentang RPP cukup bervariasi, pada intinya mereka cukup baik dalam memahami tentang media, walaupun ada diantara mereka RPP dalam artian yang terlalu umum. 2) Langkah-langkah yang dilakukan oleh guru SD No. 76/IX Desa Mendalo Darat Kecamatan dalam menyusun RPP adalah: a. menyiapkan alat tulis, b. Melihat dan mempelajari Buku Paket Mata Pelajaran, c. Menuliskan Rencana Pelaksanaan Pembelajaran kedalam buku. 3) Faktor penghambat bagi guru SD No. 76/IX Desa Mendalo Darat Kecamatan Jaluko Kabupaten Muaro Jambi dalam menyusun RPP adalah: a. keterbatasan finansial, b. Kurang menguasai teori penyusunan RPP yang sempurna, c. keterbatasan media pendukung. Berdasarkan hasil penelitian yang telah penulis lakukan, maka penulis memberikan saran kepada pihak guru SD No. 76/IX Mendalo Darat agar lebih kreatif dan lebih sungguh-sungguh dalam menyusun RPP agar menghasilkan susunan RPP yang standar, dan tentunya bermanfaat dalam pelaksanaan kegiatan belajar mengajar. Kata Kunci: Profesionalitas, Guru, RPP.
Nutritional Status and Virological Outcomes of Children HIV Positive Attending Anti-Retroviral Clinic at University College Hospital, Ibadan

Malnutrition has been reported as a major factor contributing to the poor outcome of effective ART in HIV infection. This study aimed to describe the relationship between the nutritional status and virological outcome of the children attending the antiretroviral clinic at University College Hospital (UCH) Ibadan, Nigeria. Among the 159 (55.3% males and 44.7% females) children studied, almost half (42.8%) were orphans and the majority 56.6% were aged 120 - 180 months old. More than half (74.2%) had achieved viral suppression and significant associations were observed between viral load and stunting as well as between CD4 count and the age of the children (P < 0.05). The prevalence of stunting, wasting, and underweight was 27.7%, 9.4%, and 13.6% re-spectively. These indices reinforce the need for nutrition education and the provision of food supplements to improve the nutritional status of children infected with HIV.
Evaluation of Serum Levels of Insulin-Like Growth Factor 1 and Insulin-Like Growth Factor-Binding Protein 3 in Patients With Colorectal Cancer: A Case-Control Study

Background/aim: Limited information is available about the relationship between colorectal cancer (CRC) and serum concentration of insulin-like growth factor 1 (IGF1) and insulin-like growth factor-binding protein 3 (IGFBP3). This study aims to compare the serum levels of IGF1and IGFBP3 in colorectal cancer cases and controls and to assess the relationship between their level and the demographic and histopathological characteristics. Methods: A case-control study in which 50 patients with colorectal cancer and 50 controls matched by gender and age were compared regarding the demographic characteristics and the level of both IGF1 and IGFBP3. The correlation with different clinicopathological features was assessed. Results: Levels of IGF1 were significantly higher while levels of IGFBP3 were significantly lower among cases compared to control. IGF1 was significantly higher among patients with liver metastasis, lymph node (LN) spread, and lymphovenous invasions and did not show significant association with gender, smoking status, family history, or primary site of colorectal cancer. Lower IGFBP3 was significantly high among patients with liver and lymph node metastasis, lymphovenous invasion, and patients with positive family history. This significant negative correlation was also detected between IGFBP3 levels and the size of the tumor. Conclusions: High IGF1 levels and low concentrations of IGFBP3 are related to colorectal cancer and were significantly associated with liver metastasis, lymph node spread, and lymphovenous invasions. Further research is recommended to investigate if circulating IGF1 and IGFBP3 levels can be used to identify people at high risk of colorectal cancer and to investigate potential lifestyle or pharmaceutical ways to lower IGF1 bioactivity as a risk reduction strategy.
Cations and Phenolic Compounds Concentrations in Fruits of Fig Plants Exposed to Moderate Levels of Salinity

Fig trees are often grown in areas affected by salinity problems. We investigated changes in the concentrations of 15 phenolic compounds and mineral elements (Mg, Ca, K, Zn, Cu, Mn, Mo, Fe, Na) in fruits of fig plants (Ficus carica L. cv. Dottato) subjected to irrigation with saline water (100 mM of NaCl) for 28 days. We used UHPLC-MS/MS techniques to determine chlorogenic acid, tiliroside, catechin, epicatechin (ECTC), p-coumaric acid, trans-ferulic acid, phloridzin, phloretine, quercetagetin 7-O-glucoside, rutin, quercetin 3-O-glucoside, kaempferol 3-O-rutinoside, kaempferol 7-O-glucoside, kaempferol 3-O-glucoside, and quercetin. There was a steep gradient of Na+ concentrations between the root and the canopy of salinized plants, but leaf Na+ was similar in control and salt-treated plants. Quercetin, ECTC, and chlorogenic acid were the most abundant phenolic compounds in fig fruits. Salinity increased total phenols by 5.6%, but this increase was significant only for ECTC. Salt stress significantly increased Zn and Mg concentration in the fruit. Leaf levels of K, Mg, Ca, and Mn were similar in control and salinized plants. Moderate salt stress appears to improve fig fruit quality because of its positive effect on nutrients and antioxidant compounds such as epicatechin.
Assessment of risk paths in construction projects

Risk identification is the most important step in project risk management (PRM), as the risk models are constructed based on previously defined risk sources and their interrelations. Although previous studies have concentrated on a one-way relation between risk factors, there are cause-effect relationships between risk sources, events and consequences. 'Risk paths' represent the causal relationships between risk sources, events and consequences and they should be assessed during risk identification, rather than individual risk factors. Furthermore, a complete risk assessment cannot be achieved without 'vulnerability' that shows the characteristics of a system to react to risk factors. Major aim of this paper is to propose a 'risk path assessment model' to overcome this shortcoming in PRM by combining 'risk path' and 'vulnerability' concepts. The 'risk path assessment model' includes risk and vulnerability (RV) parameters as well as their direct and indirect relationships. The model assesses RV by evaluating the level of vulnerability and magnitude of 'change' in a given project, so that the final impact of risk events on the project cost and duration is obtained.
Surveillance of Brucella in Red Meat Sold at Retail Outlets

Brucellosis in the Middle East is endemic and is associated with health burdens and economic losses for animals and humans. Transmission of Brucella from animal hosts to humans is prevalent in endemic areas, especially developing countries. This study aimed at screening for the brucellae in different fresh red meat sold in retail markets in Erbil city, Iraq. A total of 410 samples were collected between July and December 2019 and analyzed by serological and bacteriological tests for Brucella spp. by Rose Bengal Test (RBT), ELISA, and traditional bacterial culture. The prevalence of Brucella was 9.3, 7.8 and 7.1 % by RBT, ELISA, and bacteriological analysis, respectively. Both B. abortus and B. melitensis were detected in 3.17 % and 3.90 % of collected samples, respectively. In terms of seasonal variation, autumn was found to be associated with a decrease in seroprevalence. RBT was found to be suitable for ruling out the disease, but its positive results should be confirmed. The overall prevalence of Brucella in meat or the source livestock is alarming and requires considerable actions to prevent the transmission of brucellae to humans. HIGHLIGHTS The prevalence of Brucella in meat samples sold in Erbil is ~ 7 - 10 % Rose Bengal Test is convenient ruling out the disease in animals but its positive results should be confirmed The seasonality of Brucella in livestock of Erbil showed slight decrease during the autumn season GRAPHICAL ABSTRACT
Propolis: effects on the sanitisation of hatching eggs

SUMMARY The use of sanitisers, with natural compounds as active ingredients in their formulations, can be of great value in the sanitisation of hatching eggs. Here, we review the effects of sanitising hatching eggs with propolis on the eggshell microbiota, hatchability and survival of post-hatch chicks. We demonstrate that propolis is an appropriate and promising option for sanitising hatching eggs, as it helps in the reduction of microbial load on the eggshell (total aerobic mesophilic bacteria and fungi) and increases embryo safety. Typically, propolis does not negatively affect the hatchability percentage and can, in some cases, improve this rate by up to 11%. Thus, we reinforce the positive impact of natural products on poultry production.
Communicating Climate Change to a Local but Diverse Audience: On the Positive Impact of Locality Framing

ABSTRACT This study investigates the impact of locality framing in infographics about sea level rise as a consequence of anthropogenic climate change (ACC). Our experiment sampled solely inhabitants of Hoek van Holland (HvH), a coastal town in the Netherlands for which future sea level rise is a pertinent issue. We analyzed the participants’ attitudes towards ACC mitigating behaviors, and found that an infographic with a local, HvH oriented frame had a higher positive impact on attitudinal change than an infographic with a more general, global frame. To account for demographic variation between participant samples in previous studies on locality framing, whose findings were inconsistent, we also tested if the observed effect of locality framing was moderated by gender, age, education level, income, political background, and religiosity. This was not the case. Our findings advocate for the application of local frames in ACC communication, irrespective of the target population’s demographic characteristics.
Tax Evasion, Behavioral Microsimulation Models and Flat-Rate Tax Reforms: Analysis for Italy

It is sometimes argued that a flat-rate tax reform can reduce tax noncompliance. The argument is, however, inconsistent with the so-called Yitzhaki’s puzzle of the classical expected utility (EU) model. The latter predicts an increase, rather than a reduction, in tax evasion following a cut in the tax rates resulting from a flat-rate reform. We study the impact of a flat-rate tax in a microsimulation tax-benefit model of Italy, which allows us to analyze various hypotheses of tax evasion behavior. In addition to the EU model, we analyze expected utility with rank dependent probabilities (EURDP) and the model of reference dependent (RD) preference, the most favorable to overturn Yitzhaki’s puzzle. Our simulations show that a flat-rate tax would barely reduce overall evasion in Italy in all models considered. Redistributive effects are in all cases, large.
Max Covering Phasor Measurement Units Placement for Partial Power System Observability

Phasor Measurement Units (PMUs) are key elements in secure monitoring and control operations of the power network. Most existing algorithms consider the full power grid observability for the PMU placement problem with the objective of minimizing the cost assuming the availability of the resources. This paper presents a PMU placement approach to ensure maximum coverage of the power network for the case where the resources are limited and full observability is not achievable. Given the limited number of PMUs the model aims to find the best placement in order to reach the maximum coverage and if possible the full power system observability. The problem formulated as an integer linear programming (ILP) model and solved for optimality. The optimization model is solved for IEEE 14, 30, 57, 118 and 2383 standard test systems incorporating the zero-injection buses. The reliability of the power system has been evaluated for the placement results reaching full network observability. The results show that with sufficient resources in hand the developed maximum covering model is comparable to the existing algorithms for full power network observability.
Temperature variation effect compensation in impedance-based structural health monitoring using neural networks

In this article, a new method for temperature compensation on the basis of artificial neural networks (ANNs) in impedance-based structural health monitoring (ISHM) has been introduced. ISHM using piezoelectric wafer active sensors (PWAS) has been extensively developed to provide detection of fault in structure. The principle of this method is based on the electromechanical coupling effect of PWAS materials. Any change in structure leads to changes in mechanical impedance of structure. The electrical impedance of PWAS can sense this change by the electromechanical coupling effect of PWAS. Therefore, the difference in this electrical impedance for undamaged and damaged structures can be considered as a damage index to detect the damage in structure. Since physical and mechanical properties of structure also PWAS materials are temperature dependent, so this electrical impedance of PWAS will be affected by temperature changes. Consequently, the variation in environmental or service temperatures can be detected erroneously as damage in ISHM method. In this article, a new method using ANN based on radial basis function (RBF) has been proposed and developed to compensate the temperature effect on the damage index. A steel plate and gas pipe with bolted joints are considered as two case studies for the performance evaluation of the proposed fault detection methodology. Results confirm that the proposed method using the ANN can be effectively utilized to compensate temperature variation for damage detection in different structures.
Efficacy of targeted therapy in patients with HER2‐positive non‐small cell lung cancer: A systematic review and meta‐analysis

Anti‐human epidermal growth factor receptor 2 (HER2) therapy is an effective treatment for HER2‐positive gastric and breast malignancies. However, the efficacy of HER2‐targeted therapy in non‐small cell lung cancer (NSCLC) patients with HER2 alterations remains controversial. We searched studies on HER2‐targeted therapy in NSCLC patients that reported objective response rate (ORR), disease control rate (DCR) and progressionfree survival (PFS) published from database inception to 30 May 2021. A total of 32 trials involving 958 patients were included. The ORRs of HER2‐TKIs targeted therapy, humanised monoclonal antibody, trastuzumab‐based treatment and antibody‐drug conjugate (ADC) (T‐DM1) were 22% (95% CI 11–31), 23% (95% CI 20–65), 26% (95% CI 14–39) and 16% (95% CI _6–37), while that of ADC (DS‐8201) was 60% (95% CI 35–85). The DCRs of these groups were 59% (95% CI 49–69), 39% (95% CI _9–88), 63% (95% CI 37–89), 31% (95% CI 4–58) and 87% (95% CI 62–112), respectively. In the subgroup analysis, numerically higher ORRs and DCRs were observed in the poziotinib (38%; 75%) and pyrotinib (35%; 83%) groups. The median PFSs of these groups were 5.51 months, 3.09 months, 4.61 months, 2.65 months and 12.04 months, respectively. HER2‐targeted therapy can be considered an acceptable treatment strategy for NSCLC patients with HER2 alterations. In particular, ADC (DS‐8201), pyrotinib and poziotinib demonstrated promising anti‐tumour activity in HER2‐positive NSCLC.
Emerging accessibility patterns in long telomeric overhangs

We present single molecule experimental and computational modeling studies investigating the accessibility of human telomeric overhangs of physiologically relevant lengths. We studied 25 different overhangs that contain 4-28 repeats of GGGTTA (G-Tract) sequence and accommodate 1-7 tandem G-quadruplex (GQ) structures. Using FRET-PAINT method, we probed the distribution of accessible sites via a short imager strand, which is complementary to a G-Tract and transiently binds to available sites. We report accessibility patterns that periodically change with overhang length and interpret these patterns in terms of the underlying folding landscape and folding frustration. Overhangs that have [4n]G-Tracts, (12, 16, 20…), demonstrate the broadest accessibility patterns where the PNA probe accesses G-Tracts throughout the overhang. On the other hand, constructs with [4n+2]G-Tracts, (14, 18, 22…), have narrower patterns where the neighborhood of the junction between single and double stranded telomere is most accessible. We interpret these results as the folding frustration being higher in [4n]G-Tract constructs compared to [4n+2]G-Tract constructs. We also developed a computational model that tests the consistency of different folding stabilities and cooperativities between neighboring GQs with the observed accessibility patterns. Our experimental and computational studies suggest the neighborhood of the junction between single and double stranded telomere is least stable and most accessible, which is significant as this is a potential site where the connection between POT1/TPP1 (bound to single stranded telomere) and other shelterin proteins (localized on double stranded telomere) is established. Significance Statement The ends of eukaryotic linear chromosomes are capped by telomeres which terminate with a single-stranded overhang. Telomeric overhangs fold into compact structures, called G-quadruplex, that inhibit access to these critical genomic sites. We report single molecule measurements and computational modeling studies probing the accessibility of a set of human telomeric overhangs that covers a significant portion of the physiologically relevant length scale. We observe novel accessibility patterns which have a well-defined periodicity and show that certain regions are significantly more accessible than others. These accessibility patterns also suggest the underlying folding frustration of G-quadruplexes depends on telomere length. These patterns have significant implications for regulating the access of DNA processing enzymes and DNA binding proteins that can target telomeric overhangs.