Miracle-dz/UniFAR-FTUs huggingface dataset:
Molecular Biomarker Expression in Window of Opportunity Studies for Oestrogen Receptor Positive Breast Cancer—A Systematic Review of the Literature

Simple Summary Window of opportunity (WoO) trials allow the opportunity to assess the use of drugs in breast cancer research before treatment has commenced. The aim of this review of the literature is to review WoO trials in patients with oestrogen receptor-positive (ER+) breast cancer to help guide treatment. This will be useful for patients who receive drug treatment before surgery, or as an alternative to surgery in older, more frail adults. Abstract Window of opportunity (WoO) trials create the opportunity to demonstrate pharmacodynamic parameters of a drug in vivo and have increasing use in breast cancer research. Most breast cancer tumours are oestrogen receptor-positive (ER+), leading to the development of multiple treatment options tailored towards this particular tumour subtype. The aim of this literature review is to review WoO trials pertaining to the pharmacodynamic activity of drugs available for use in ER+ breast cancer in order to help guide treatment for patients receiving neoadjuvant and primary endocrine therapy. Five databases (EMBASE, Cochrane, MEDLINE, PubMed, Web of Science) were searched for eligible studies. Studies performed in treatment-naïve patients with histologically confirmed ER+ breast cancer were included if they acquired pre- and post-treatment biopsies, compared measurement of a proteomic biomarker between these two biopsies and delivered treatment for a maximum mean duration of 31 days. Fifteen studies were eligible for inclusion and covered six different drug classes: three endocrine therapies (ETs) including aromatase inhibitors (AIs), selective oestrogen receptor modulators (SERMs), selective oestrogen receptor degraders (SERDs) and three non-ETs including mTOR inhibitors, AKT inhibitors and synthetic oestrogens. Ki67 was the most frequently measured marker, appearing in all studies. Progesterone receptor (PR) and ER were the next most frequently measured markers, appearing five and four studies, respectively. All three of these markers were significantly downregulated in both AIs and SERDs; Ki67 alone was downregulated in SERMs. Less commonly assessed markers including pS6, pGSH3B, FSH and IGF1 were downregulated while CD34, pAKT and SHBG were significantly upregulated. There were no significant changes in the other biomarkers measured such as phosphate and tensin homolog (PTEN), Bax and Bcl-2.WoO studies have been widely utilised within the ER+ breast cancer subtype, demonstrating their worth in pharmacodynamic research. However, research remains focused upon routinely measured biomarkers such ER PR and Ki67, with an array of less common markers sporadically used.
A review of most applicable theories and models of technology acceptance

One of the first steps to initiate a technology-related business is to perceive factors that would help users accept technology. In this regard, different models have been introduced to explain technology acceptance and determine users’ needs. These theories have psychological origins and involve comprehensively cognitive backgrounds which deal with components that predict the user’s behavior. Prediction of user’s behavior which is a major element of technology development success helps clarify the latent angles of the technology and business development for the developers. In the meantime, this article reviews general concepts of technology acceptance models and theories to provide valuable data about technology acceptance and adoption. Also, the goal of this article is to train and demonstrate these theories for the readers.
Nonlinear evolution of plasma enhancements in the auroral ionosphere i: long wavelength irregularities. Memorandum report

The linear stability and nonlinear evolution of plasma enhancements in arbitrary ambient electric fields in the diffuse auroral F region ionosphere have been studied using analytical and numerical simulation techniques. Our results that equatorward convecting plasma slabs initially limited in latitudinal extent are primarily destabilized on their poleward sides by a combination of the effects of convection and field aligned currents. Furthermore we find that the plasma enhancements break up into primary striation-like structures (elongated in the north-south direction for equatorward convection) which can form and cascade from large (approx. = 100 km) to smaller (approx. = 3 km) scale sizes on the order of an hour. The primary and associated smaller scale structures can be oriented either in the north-south or east-west (L-shell alignment) direction depending on the ambient electric field magnitude and direction.
Factors Associated With Improved A1C Among Adults With Type 1 Diabetes in the United States

Many adults with diabetes do not reach optimal glycemic targets, and, despite advances in diabetes management, diabetes technology use remains significantly lower in racial/ethnic minority groups. This study aimed to identify factors associated with achieving the recommended A1C target of <7% using data on 12,035 adults with type 1 diabetes from 15 centers participating in the T1D Exchange Quality Improvement Collaborative. Individuals attaining the target A1C were more likely to be older, White, have private health insurance, and use diabetes technology and less likely to report depressive symptoms or episodes of severe hypoglycemia or diabetic ketoacidosis than those with higher A1C levels. These findings highlight the importance of overcoming inequities in diabetes care.
Melatonin and Indole-3-Acetic Acid Synergistically Regulate Plant Growth and Stress Resistance

Plant growth and development exhibit plasticity, and plants can adapt to environmental changes and stress. Various phytohormones interact synergistically or antagonistically to regulate these responses. Melatonin and indole-3-acetic acid (IAA) are widespread across plant kingdom. Melatonin, an important member of the neuroendocrine immune regulatory network, can confer autoimmunity and protect against viral invasion. Melatonin functions as a plant growth regulator and biostimulant, with an important role in enhancing plant stress tolerance. IAA has a highly complex stress response mechanism, which participates in a series of stress induced physiological changes. This article reviews studies on the signaling pathways of melatonin and IAA, focusing on specific regulatory mechanisms. We discuss how these hormones coordinate plant growth and development and stress responses. Furthermore, the interactions between melatonin and IAA and their upstream and downstream transcriptional regulation are discussed from the perspective of modulating plant development and stress adaptation. The reviewed studies suggest that, at low concentrations, melatonin promotes IAA synthesis, whereas at high levels it reduces IAA levels. Similarly to IAA, melatonin promotes plant growth and development. IAA suppresses the melatonin induced inhibition of germination. IAA signaling plays an important role in plant growth and development, whereas melatonin signaling plays an important role in stress responses.
Factors Affecting the Career Continuation of Newly Graduated and Reinstated Dental Hygienists Who Participated in a Technical Training Program in Japan

This study aimed to identify (1) what newly graduated dental hygienists and reinstated dental hygienists consider important for preventing early turnover in their own professions and for encouraging them to continue in the profession more generally and (2) relevant factors among hygienists intending to continue working in the field. An anonymous, self-administered questionnaire survey was distributed to 215 Japanese dental hygienists who participated in the technical training programs (response rate: 72.6%). Of them, 143 participants were classified into two groups: newly graduated (NGDH, n = 32) and those reinstated to work (RDH, n = 111). Follow-up for lack of skills was most often selected as important for preventing early turnover among both groups and follow-up for lack of knowledge was significantly selected in the RDH group (p < 0.001). Regarding factors important for career continuation, NGDHs significantly selected gaining job satisfaction, whereas RDHs significantly selected working support. Relevant factors contributing to participants’ intentions to continue in the profession were job satisfaction (NGDH, OR = 8.37; RDH, OR = 8.83), career outlook (RDH, OR = 3.11), and job turnover experience because of marriage and parenting (RDH, OR = 2.70), thereby suggesting the importance of raising awareness regarding career progression and job-related rewards among dental hygienists, their educators, and the government through ongoing career education.
Highly Efficient Solution-Processed Blue Phosphorescent Organic Light-Emitting Diodes Based on Co-Dopant and Co-Host System

The low-lying HOMO level of the blue emitter and the interfacial miscibility of organic materials result in inferior hole injection, and long exciton lifetime leads to triplet-triplet annihilation (TTA) and triplet-polaron annihilation (TPA), so the efficiencies of blue phosphorescent organic light-emitting diodes (PhOLEDs) are still unsatisfactory. Herein, we design co-host and co-dopant structures to improve the efficiency of blue PhOLEDs by means of solution processing. TcTa acts as hole transport ladder due to its high-lying HOMO level, and bipolar mCPPO1 helps to balance carriers’ distribution and weaken TPA. Besides the efficient FIr6, which acts as the dominant blue dopant, FCNIrPic was introduced as the second dopant, whose higher HOMO level accelerates hole injection and high triplet energy facilitates energy transfer. An interesting phenomenon caused by microcavity effect between anode and cathode was observed. With increasing thickness of ETL, peak position of electroluminescence (EL) spectrum red shifts gradually. Once the thickness of ETL exceeded 140 nm, emission peak blue-shifts went back to its original position. Finally, the maximum current efficiency (CE), power efficiency (PE), and external quantum efficiency (EQE) of blue phosphorescent organic light-emitting diode (PhOLED) went up to 20.47 cd/A, 11.96 lm/W, and 11.62%, respectively.
Parental Human Capital Investment Responses to Children’s Disabilities

This paper investigates whether parental decisions to invest in education of their disabled children are driven by equality or efficiency. Even if parents are inequality averse, they may still choose to invest more in nondisabled children than in disabled children if there are additional costs of parental inputs associated with disability. I show that variation in family size and children’s disabilities can be used to infer whether parents are averse to inequality, exploiting the fact that parents of single children cannot possibly exhibit inequality aversion. Using Mexican cross-sectional data, I show that equality is important for parental investments in education.
Direct and Indirect Effects of Vaccines: Evidence from COVID-19 in Schools

Vaccines influence the course of pandemics both directly, by protecting the vaccinated, and indirectly through a key externality: reducing transmission to the unvaccinated. Estimating direct and indirect effects is challenging because of selective vaccine take-up. Using unique microdata from Indiana together with a natural experiment, we estimate direct effects and indirect effects at the household, school, and grade levels. To identify direct effects, we use federal age-based vaccine eligibility rules by which 12 year-olds were eligible in fall 2021 but 11 year-olds and younger were not. We identify household-level indirect effects by comparing adults residing with 12 year-olds to adults residing with 11 year-olds. We identify school-level indirect effects by comparing sixth graders in middle school (with many vaccine-eligible schoolmates) to sixth graders in elementary school (with few). We identify grade-level indirect effects using school entry age discontinuities which shift the likelihood of having 12-year old grade-mates but not vaccine eligibility. We find large direct effects of vaccines on COVID incidence, equivalent to an 80 percent effectiveness. Indirect effects at the household level are substantial, about half as large as the direct effect. However we find no schoolor grade-level indirect effects. Together our results show that vaccine spillovers are context dependent and appear larger within groups with greater mixing. JEL codes: D62, I12, I18,I21,J13
Analysis of Factors Affecting the Rate of Latent Tuberculosis Infection and Management in Pediatrics

The incidence of tuberculosis remains high in South Korea; the management of latent tuberculosis infection (LTBI) has become the prime target for reducing the infection rate. The management of pediatric LTBI is especially crucial because children can serve as a long-term source of infection upon developing active tuberculosis. Therefore, it is important to assess pediatric LTBI using contact investigation and follow-up. We conducted a retrospective study on children aged between 0 and 18 years who visited our hospital for tuberculosis contact screening from February 2012 to February 2021. Tuberculosis index cases and their clinical characteristics were also reviewed retrospectively. A total of 350 children were investigated, and 68 of 247 (27.5%) were diagnosed with LTBI. The rate of LTBI (r = 7.98, p < 0.001) and the risk of loss to follow-up (r = 27.038, p < 0.001) were higher in cases with close household contact. Sputum (r = 10.992, p < 0.001) and positive acid-fast bacillus (AFB) stain (r = 4.458, p = 0.001) in tuberculosis index cases were related to the diagnosis of LTBI in pediatric contacts. Active management is needed for tuberculosis screening in pediatric contacts, especially when the contacts are older and the index case is within the family, and when the index case has sputum and has tested positive for AFB smear.
Apparent age spreads in clusters and the role of stellar rotation

We use the Geneva Syclist isochrone models that include the effects of stellar rotation to investigate the role that rotation has on the resulting colour-magnitude diagram (CMD) of young and intermediate age clusters. We find that if a distribution of rotation velocities exists within the clusters, rotating stars will remain on the main sequence (MS) for longer, appearing to be younger than non-rotating stars within the same cluster. This results in an extended main sequence turn-off (eMSTO) that appears at young ages ($\sim30$~Myr) and lasts beyond 1~Gyr. If this eMSTO is interpreted as an age spread, the resulting age spread is proportional to the age of the cluster, i.e. young clusters ($<100$~Myr) appear to have small age spreads (10s of Myr) whereas older clusters ($\sim1$~Gyr) appear to have much larger spreads, up to a few hundred Myr. We compare the predicted spreads for a sample of rotation rates to observations of young and intermediate age clusters, and find a strong correlation between the measured 'age spread' and the age of the cluster, in good agreement with models of stellar rotation. This suggests that the 'age spreads' reported in the literature may simply be the result of a distribution of stellar rotation velocities within clusters.
Persistent Atrial Fibrillation in Elderly Patients: Limited Efficacy of Pulmonary Vein Isolation

(1) Background: Cryoballoon pulmonary vein isolation (cryoPVI) is established for symptomatic paroxysmal atrial fibrillation (AF) treatment, but its value in persistent AF is less clear. In particular, limited data are available on its efficacy in elderly patients (≥75 years) with persistent AF. Age is an important modifier of AF progression and represents a risk-factor for AF recurrence. (2) Methods: Prospective, single-center observational study to evaluate the impact of age on efficacy and safety of cryoPVI in elderly patients. Primary efficacy endpoint was symptomatic AF recurrence after 90-day blanking period. Primary safety endpoints were death from any cause, procedure-associated complications or stroke/transient ischemic attack. Median follow-up was 17 months (range 3–24). (3) Results: We included 268 patients with persistent AF (94 ≥ 75 years of age). Multivariate Cox regression analysis identified age as the only independent factor influencing AF recurrence in the overall cohort (p = 0.006). To minimize confounding bias in efficacy and safety analysis of cryoPVI, we matched younger and elderly patients with respect to baseline characteristics. At 24 months, primary efficacy endpoint occurred in 13/69 patients <75 years and 31/69 patients ≥75 years of age (24 months Kaplan–Meier event-rate estimates, HR 0.34; 95% CI, 0.19 to 0.62; log-rank p = 0.0004). No differences were observed in the occurrence of safety end points. (4) Conclusions: Elderly (≥75 years) patients with persistent AF undergoing cryoPVI had an approximately threefold higher risk of symptomatic AF recurrence than matched younger patients. Accordingly, other treatment modalities may be evaluated in this population.
Behavioural Responses of Common Dolphins Delphinus delphis to a Bio-Inspired Acoustic Device for Limiting Fishery By-Catch

By-catch is the most direct threat to marine mammals globally. Acoustic repellent devices (pingers) have been developed to reduce dolphin by-catch. However, mixed results regarding their efficiency have been reported. Here, we present a new bio-inspired acoustic beacon, emitting returning echoes from the echolocation clicks of a common dolphin ‘Delphinus delphis’ from a fishing net, to inform dolphins of its presence. Using surface visual observations and the automatic detection of echolocation clicks, buzzes, burst-pulses and whistles, we assessed wild dolphins’ behavioural responses during sequential experiments (i.e., before, during and after the beacon’s emission), with or without setting a net. When the device was activated, the mean number of echolocation clicks and whistling time of dolphins significantly increased by a factor of 2.46 and 3.38, respectively (p < 0.01). Visual surface observations showed attentive behaviours of dolphins, which kept a distance of several metres away from the emission source before calmly leaving. No differences were observed among sequences for buzzes/burst-pulses. Our results highlight that this prototype led common dolphins to echolocate more and communicate differently, and it would favour net detection. Complementary tests of the device during the fishing activities of professional fishermen should further contribute to assessment of its efficiency.
Dietary exposure to acrylamide of university students in Ningxia of Northwest China and the effect on their neurobehavioral performance and oxidative stress in serum

Abstract This study aims to investigate dietary exposure to acrylamide (AA) and also make an assessment of its effect on the neurobehavioral performance and oxidative stress in the serum of university students in Ningxia. The place primarily consists of arid, dry desert, and wheat‐based foods are the staple food there. A total of 803 university students in Ningxia participated in this cross‐sectional study. Diet intake of AA was estimated with FFQ. The AA risk was calculated as margin of exposure (MOE) values. NCTB questionnaires were used to assess neurobehavioral performance. The serum oxidative stress levels of the university students were measured as GSH, MDA, and SOD. The mean for AA exposure of university students was 0.515 μg kg−1 bw day−1. The highest contributor was traditional Chinese grain products, representing 34.71% of the total daily AA intake. Followed were deep‐fried potato products, traditional Western grain products, soft drinks, and nuts, which accounted for 23.87%, 16.59%, 11.15%, and 11%, respectively. The median AA exposure were 480 (BMDL10 = 0.18 mg kg−1 bw day−1) and 827 (BMDL10 = 0.31 mg kg−1 bw day−1), respectively. The results indicated that diet AA may have an effect on the emotional status and neurobehavior among this population. We observed no significant differences in oxidative stress under the three levels of AA exposure (p > .05). It suggests a health concern for university students in Northwest China that should get society's attention.
In Vitro Cytotoxicity Evaluation of Plastoquinone Analogues against Colorectal and Breast Cancers along with In Silico Insights

Colorectal cancer (CRC) and breast cancer are leading causes of death globally, due to significant challenges in detection and management. The late-stage diagnosis and treatment failures require the discovery of potential anticancer agents to achieve a satisfactory therapeutic effect. We have previously reported a series of plastoquinone analogues to understand their cytotoxic profile. Among these derivatives, three of them (AQ-11, AQ-12, and AQ-15) were selected by the National Cancer Institute (NCI) to evaluate their in vitro antiproliferative activity against a panel of 60 human tumor cell lines. AQ-12 exhibited significant antiproliferative activity against HCT-116 CRC and MCF-7 breast cancer cells at a single dose and further five doses. MTT assay was also performed for AQ-12 at different concentrations against these two cells, implying that AQ-12 exerted notable cytotoxicity toward HCT-116 (IC50 = 5.11 ± 2.14 μM) and MCF-7 (IC50 = 6.06 ± 3.09 μM) cells in comparison with cisplatin (IC50 = 23.68 ± 6.81 μM and 19.67 ± 5.94 μM, respectively). This compound also augmented apoptosis in HCT-116 (62.30%) and MCF-7 (64.60%) cells comparable to cisplatin (67.30% and 78.80%, respectively). Molecular docking studies showed that AQ-12 bound to DNA, forming hydrogen bonding through the quinone scaffold. In silico pharmacokinetic determinants indicated that AQ-12 demonstrated drug-likeness with a remarkable pharmacokinetic profile for future mechanistic anti-CRC and anti-breast cancer activity studies.
Some Effects of Vanes and of Turbulence in Two-Dimensional Wide-Angle Subsonic Diffusers

Note presenting tests on two aspects of the behavior of wide-angle, plane-walled, two-dimensional diffusers with essentially incompressible flow. First, a thorough study of the flow mechanism has been made during dye injection in a water table. Second, data are presented which demonstrate means for producing efficient diffusers for total included angles up to at least 45 degrees by use of simple, short, flat vanes.
Dual Immune Regulatory Roles of Interleukin-33 in Pathological Conditions

Interleukin-33 (IL-33), a member of the IL-1 cytokine family and a multifunctional cytokine, plays critical roles in maintaining host homeostasis and in pathological conditions, such as allergy, infectious diseases, and cancer, by acting on multiple types of immune cells and promoting type 1 and 2 immune responses. IL-33 is rapidly released by immune and non-immune cells upon stimulation by stress, acting as an “alarmin” by binding to its receptor, suppression of tumorigenicity 2 (ST2), to trigger downstream signaling pathways and activate inflammatory and immune responses. It has been recognized that IL-33 displays dual-functioning immune regulatory effects in many diseases and has both pro- and anti-tumorigenic effects, likely depending on its primary target cells, IL-33/sST2 expression levels, cellular context, and the cytokine microenvironment. Herein, we summarize our current understanding of the biological functions of IL-33 and its roles in the pathogenesis of various conditions, including inflammatory and autoimmune diseases, infections, cancers, and cases of organ transplantation. We emphasize the nature of context-dependent dual immune regulatory functions of IL-33 in many cells and diseases and review systemic studies to understand the distinct roles of IL-33 in different cells, which is essential to the development of more effective diagnoses and therapeutic approaches for IL-33-related diseases.