Miracle-dz/UniFAR-FTUs huggingface dataset:
Relationship Between the Lateral Plantar Artery and the Retrograde Intramedullary Nail During Tibiotalar and Subtalar Arthrodesis: A Fresh Cadaveric Study

Background Tibiotalocalcaneal (TTC) arthrodesis with retrograde intramedullary nailing has become established. Iatrogenic injury to the vasculature (eg, lateral plantar artery [LPA] pseudoaneurysm) during insertion of the nail has been reported. The aim of this study was to identify the safe zone that avoids injury to the LPA during TTC arthrodesis. Methods The retrograde lateral curved nail entry point should be in line with the midpoint of the tibial medullary canal and the lateral column of the calcaneus. Enhanced 3-dimensional computed tomography scans of 26 fresh cadaveric feet were assessed. The closest distance between the LPA and the edge of the nail entry point was measured in the plantar view. Results The closest mean distance between the LPA and the edge of the nail entry point was 6.7 mm for all 26 feet, 12.8 mm for 3 feet (11.5%) in which the LPA did not cross the medial wall of the calcaneus, 8.1 mm for 9 (34.1%) in which the point where the LPA crossed the medial wall of the calcaneus was anterior to the center of the nail entry point, and 4.2 mm for 14 (53.8%) feet in which this point was posterior to the center of the nail entry point. Conclusions Care should be taken to avoid the LPA during reaming at the nail entry point, especially when the point where the LPA crosses the medial wall of the calcaneus is posterior to the center of the nail entry point. Levels of Evidence: IV, cadaveric study
Evaluation of Sintering of Nanometer-Sized Titania Using Aerosol Method

The sintering of titania agglomerates consisting of nanometer primary particles in a heated gas flow is investigated under gas temperatures from room temperature to 1673 K. The test titania agglomerates are produced by thermal decomposition or hydrolysis of TTIP (titanium tetraisopropoxide) vapor. The size changes of the agglomerates of 30–100 nm in diameter are measured using a TDMA (Tandem Differential Mobility Analyzer) system. At a temperature lower than about 1000 K, the agglomerates do not change in size with increasing heating temperature, but a sudden decrease in size is detected at 1000 to 1500 K. From TEM observation, densification of agglomerates accompanying primary particle growth is observed. These experimental results for the rate of reduction in surface area are explained quantitatively by solving the basic equation of sintering under the calculated temperature profile.
Isobutyryl‐CoA dehydrogenase deficiency associated with autism in a girl without an alternative genetic diagnosis by trio whole exome sequencing: A case report

Isobutyryl‐CoA dehydrogenase (IBD) is a mitochondrial enzyme catalysing the third step in the degradation of the essential branched‐chain amino acid valine and is encoded by ACAD8. ACAD8 mutations lead to isobutyryl‐CoA dehydrogenase deficiency (IBDD), which is identified by increased C4‐acylcarnitine levels. Affected individuals are either asymptomatic or display a variety of symptoms during infancy, including speech delay, cognitive impairment, failure to thrive, hypotonia, and emesis.
Contribution of historical precipitation change to US flood damages

Significance Precipitation extremes have increased in many regions of the United States, suggesting that climate change may be exacerbating the cost of flooding. However, the impact of historical precipitation change on the cost of US flood damages remains poorly quantified. Applying empirical analysis to historical precipitation and flood damages, we estimate that approximately one-third (36%) of the cost of flood damages over 1988 to 2017 is a result of historical precipitation changes. Climate models show that anthropogenic climate change has increased the probability of heavy precipitation associated with these costs. Our results provide information quantifying the costs of climate change, and suggest that lower levels of future warming would very likely reduce flooding losses relative to the current global warming trajectory. Precipitation extremes have increased across many regions of the United States, with further increases anticipated in response to additional global warming. Quantifying the impact of these precipitation changes on flood damages is necessary to estimate the costs of climate change. However, there is little empirical evidence linking changes in precipitation to the historically observed increase in flood losses. We use >6,600 reports of state-level flood damage to quantify the historical relationship between precipitation and flood damages in the United States. Our results show a significant, positive effect of both monthly and 5-d state-level precipitation on state-level flood damages. In addition, we find that historical precipitation changes have contributed approximately one-third of cumulative flood damages over 1988 to 2017 (primary estimate 36%; 95% CI 20 to 46%), with the cumulative impact of precipitation change totaling $73 billion (95% CI 39 to $91 billion). Further, climate models show that anthropogenic climate forcing has increased the probability of exceeding precipitation thresholds at the extremely wet quantiles that are responsible for most flood damages. Climate models project continued intensification of wet conditions over the next three decades, although a trajectory consistent with UN Paris Agreement goals significantly curbs that intensification. Taken together, our results quantify the contribution of precipitation trends to recent increases in flood damages, advance estimates of the costs associated with historical greenhouse gas emissions, and provide further evidence that lower levels of future warming are very likely to reduce financial losses relative to the current global warming trajectory.
Rapid and Sensitive Quantification of the Pesticide Lindane by Polymer Modified Electrochemical Sensor

Lindane is documented by the Environmental Protection Agency (EPA) as one of the most toxic registered pesticides. Conventional detection of lindane in the environment requires manual field sampling and complex, time-consuming analytical sample handling relying on skilled labor. In this study, an electrochemical sensing system based on a modified electrode is reported. The system is capable of detecting lindane in aqueous medium in only 20 s. The surface of a conventional carbon electrode is modified with a film of conductive polymer that enables detection of lindane down to 30 nanomolar. The electrode modification procedure is simple and results in a robust sensor that can withstand intensive use. The sensitivity of the sensor is 7.18 µA/µM and the performance was demonstrated in the determination of lindane in spiked ground water. This suggests that the sensor is potentially capable of providing useful readings for decision makers. The rapid and sensitive quantification of lindane in aqueous medium is one step forward to new opportunities for direct, autonomous control of the pesticide level in the environment.
Wild bees as winners and losers: Relative impacts of landscape composition, quality, and climate

Wild bees, like many other taxa, are threatened by land‐use and climate change, which, in turn, jeopardizes pollination of crops and wild plants. Understanding how land‐use and climate factors interact is critical to predicting and managing pollinator populations and ensuring adequate pollination services, but most studies have evaluated either land‐use or climate effects, not both. Furthermore, bee species are incredibly variable, spanning an array of behavioral, physiological, and life‐history traits that can increase or decrease resilience to land‐use or climate change. Thus, there are likely bee species that benefit, while others suffer, from changing climate and land use, but few studies have documented taxon‐specific trends. To address these critical knowledge gaps, we analyzed a long‐term dataset of wild bee occurrences from Maryland, Delaware, and Washington DC, USA, examining how different bee genera and functional groups respond to landscape composition, quality, and climate factors. Despite a large body of literature documenting land‐use effects on wild bees, in this study, climate factors emerged as the main drivers of wild‐bee abundance and richness. For wild‐bee communities in spring and summer/fall, temperature and precipitation were more important predictors than landscape composition, landscape quality, or topography. However, relationships varied substantially between wild‐bee genera and functional groups. In the Northeast USA, past trends and future predictions show a changing climate with warmer winters, more intense precipitation in winter and spring, and longer growing seasons with higher maximum temperatures. In almost all of our analyses, these conditions were associated with lower abundance of wild bees. Wild‐bee richness results were more mixed, including neutral and positive relationships with predicted temperature and precipitation patterns. Thus, in this region and undoubtedly more broadly, changing climate poses a significant threat to wild‐bee communities.
Performance of a Portable near Infrared Instrument for Brix Value Determination of Intact Mango Fruit

The performance of a commercially-available, portable NIR instrument “FT20” for fruit quality evaluation was investigated using mango fruits. The calibration result for the FT20 was compared with the result for the Foss NIRSystems 6500. Partial least squares (PLS) regression was used to make the calibration equations. It was found that the calibration equation using spectral data obtained with the FT20 had similar accuracy to that using Foss NIRSystems 6500 spectra. The SEPs of calibration equations were 0.40 °Brix for both instruments.
The impact of disability on employment and financial security following the outbreak of the 2020 COVID-19 pandemic in the UK

Abstract Background The coronavirus disease 2019 (COVID-19) pandemic may have a greater impact on people with disabilities than non-disabled people. Our aim was to compare the short-term impact of the 2020 COVID-19 pandemic and first lockdown on the employment and financial security of working age adults with and without disabilities in the UK. Methods Secondary analysis of data collected in Wave 9 and the special April, May and June COVID-19 monthly surveys of ‘Understanding Society’, the UK’s main annual household panel study. Results During the first 3 months of the introduction of the COVID-19 lockdown in the UK, respondents with disability were more likely than their peers to be working reduced hours and experience higher levels of financial stress. These differences were attenuated, but not eliminated, when estimates were adjusted to take account of pre-lockdown financial status. Conclusions Working age adults with disability were particularly disadvantaged by the financial impact of the COVID-19 lockdown in the UK. The UN Secretary-General António Guterres has stated the need for a disability-inclusive COVID-19 government response. The results of our analysis suggest that these pleas have either not been heeded, or if measures have been implemented, they have so far been ineffectual in the UK.
Equity for women and underrepresented minorities in STEM: Graduate experiences and career plans in chemistry

Significance On June 10, 2020, as part of the Black Lives Matter movement, scientists in the United States and throughout the world paused to consider how systematic racism affects the scientific enterprise. As a result, many academic departments are now assessing policies and practices that may contribute to this situation. This paper provides evidence of the nature of inequities related to race–ethnicity and gender in graduate school experiences and career plans of PhD students in one science, technology, engineering, and math (STEM) discipline, chemistry. The results can help promote understanding of the problems and guide efforts toward equity within STEM and, potentially, other academic areas. In turn, these changes can strengthen the scientific enterprise and the well-being of society. Recent events prompted scientists in the United States and throughout the world to consider how systematic racism affects the scientific enterprise. This paper provides evidence of inequities related to race–ethnicity and gender in graduate school experiences and career plans of PhD students in the top 100 ranked departments in one science, technology, engineering, and math (STEM) discipline, chemistry. Mixed-model regression analyses were used to examine factors that might moderate these differences. The results show that graduate students who identified as a member of a racial/ethnic group traditionally underrepresented in chemistry (underrepresented minorities, URM) were significantly less likely than other students to report that their financial support was sufficient to meet their needs. They were also less likely to report having supportive relationships with peers and postdocs. Women, and especially URM women, were significantly less likely to report supportive relationships with advisors. Despite their more negative experiences in graduate school, students who identified as URM expressed greater commitment to finishing their degree and staying in the field. When there was at least one faculty member within their departments who also identified as URM they were also more likely than other students to aspire to a university professorship with an emphasis on research. Men were significantly more likely than women to express strong commitment to finishing the PhD and remaining in chemistry, but this difference was stronger in top-ranked departments. Men were also more likely than women to aspire to a professorship with an emphasis on research, and this difference remained when individual and departmental-level variables were controlled.
Response of Novel Functionally-Graded Prepacked Aggregate Fibrous Concrete against Low Velocity Repeated Projectile Impacts

Preplaced Aggregate Fibrous Concrete (PAFC) is a newly minted composite that has recently become more popular. The production of PAFC involves two essential processes; first, the fibres and coarse aggregate were filled into the empty framework to form the first layer of a natural skeleton, followed by grout injecting. A cement grout fills the voids in the first layer skeleton with slight compaction. This process is repeated to complete the remaining layers; hence, a type of Functionally-graded Preplaced Aggregate Fibrous Concrete (FPAFC) is obtained. The most recent studies revealed that the literature regarding the high-velocity projectile impact on fibrous concrete is well documented; however, the low-velocity repeated projectile impact on PAFC is still unexplored and needs particular emphasis. This research aims to investigate the FPAFC made with a new type of steel and polypropylene fibres against low-velocity projectile impact to fill this research gap. In the current study, twelve mixes were prepared with mono and hybrid combinations of fibres for pioneering the possible utilization of fibres in FPAFC. The maximum fibre dosage in this study is limited to 2.4%. The projectile impact resistance of FPAFC was assessed in line with penetration depth, front and rear damage surface area, weight loss, damage ratio and failure pattern. Additionally, a simplified analytical model was introduced to compute the ejected composite mass from the tested specimens. The results revealed that the addition of steel fibre in a single layer FPAFC exhibited an increasing compressive strength trend compared to the two/three-layered FPAFC. Furthermore, increasing the dosage of fibre at the bottom and top layers of FPAFC with a hybrid combination alleviates the spalling with an increasing number of impacts. The results from this research offer the reference information for more detailed research and studies of FPAFC under low-velocity projectile impact.
Metabolite profiling of Cyanthillium cinereum (L.) H. Rob. and its herbal formulation by tandem mass spectroscopic analysis

Abstract Cyanthillium cinereum is a medicinal plant commonly known as little ironweed is used in various traditional systems of medicines. In Ayurveda, it is known as Sahadevi and is used as remedy for many ailments. It has been reported to possess numerous biological properties including diaphoretic, anthelmintic, diuretic, lithontriptic, anti-inflammatory and anticancer activities. Metabolite profiling of aqueous extract of C. cinereum (CCE) and its herbal formulation KGS tablet has been carried out by liquid chromatography tandem mass spectroscopic analysis. ESI-MS/MS based characterisation led to the identification of several bioactive phytochemicals belonging to various classes of metabolites like phenolic acids, phenolic glycosides, flavonoids and anthocyanin. Most of the identified compounds are known for their various biological properties, such as antioxidant, anti-inflammatory and anticancer activities. Graphical Abstract
Bromamine T (BAT) Exerts Stronger Anti-Cancer Properties than Taurine (Tau)

Simple Summary Taurine (Tau) has been shown to inhibit cancer growth. However, the mechanisms that underlie the growth-inhibitory effects of Tau remain obscure in both colon and breast cancer. In parallel, N-bromotaurine (TauNHBr) and a stable active bromine molecule, bromamine T (BAT), appear to exert strong anti-inflammatory effects. To our knowledge, this is the first study that evaluates the anti-cancer effects of BAT and its underlying mechanisms. To gain a comprehensive picture of the cytotoxic effect of BAT on colon and breast cancer, we compared its effect with that of Tau. Our data support that BAT exerts a superior anti-cancer effect than Tau, through the induction of cell death, probably due to the activation of distinct mitogen-activated protein kinase (MAPK) family members. Interestingly, BAT inhibits colon carcinogenesis in vivo to a greater extent than Tau. Our data significantly add to the use of BAT as a novel therapeutic modality in colon and breast cancer. Abstract Background: Taurine (Tau) ameliorates cancer pathogenesis. Researchers have focused on the functional properties of bromamine T (BAT), a stable active bromine molecule. Both N-bromotaurine (TauNHBr) and BAT exert potent anti-inflammatory properties, but the landscape remains obscure concerning the anti-cancer effect of BAT. Methods: We used Crystal Violet, colony formation, flow cytometry and Western blot experiments to evaluate the effect of BAT and Tau on the apoptosis and autophagy of cancer cells. Xenograft experiments were used to determine the in vivo cytotoxicity of either agent. Results: We demonstrated that both BAT and Tau inhibited the growth of human colon, breast, cervical and skin cancer cell lines. Among them, BAT exerted the greatest cytotoxic effect on both RKO and MDA-MB-468 cells. In particular, BAT increased the phosphorylation of c-Jun N-terminal kinases (JNK½), p38 mitogen-activated protein kinase (MAPK), and extracellular-signal-regulated kinases (ERK½), thereby inducing mitochondrial apoptosis and autophagy in RKO cells. In contrast, Tau exerted its cytotoxic effect by upregulating JNK½ forms, thus triggering mitochondrial apoptosis in RKO cells. Accordingly, colon cancer growth was impaired in vivo. Conclusions: BAT and Tau exerted their anti-tumor properties through the induction of (i) mitochondrial apoptosis, (ii) the MAPK family, and iii) autophagy, providing novel anti-cancer therapeutic modalities.
GLUTEN QUALITY PREDICTION AND CORRELATION STUDIES IN SPRING WHEATS

Gluten, “cohesive, viscoelastic, proteinaceous material prepared as a by-product of the starch isolation from wheat flour” and the storage and dough-forming protein of wheat flour, is the key to the unique ability of wheat to suit the production of leavened products. Wet gluten was only affected by wheat varieties, while dry gluten was affected by wheat varieties, crop years and their interaction. The wet and dry gluten ranged 8.0–43.13% and 2.58–14.55%, respectively, and were positively correlated with Zeleny value, sodium dodecyl sulfate sedimentation value and falling number. The gluten content was higher in Pavon, SA 42 and Faisalabad 85, while Zeleny value was higher in GA 02 and C 518, resulting in better gluten quality. Zeleny value was negatively correlated with crude protein content (r = –0.1857*). The lowest amount of wet and dry gluten was detected in Triticale and durum wheats as compared to common wheats. Zeleny value and sedimentation value may be used as indicators of gluten content and quality while working on wheats. The information thus collected will be valuable for cereal chemists and wheat breeders for improvements in their future breeding programs. PRACTICAL APPLICATIONS This research work will be a breakthrough and helpful for wheat breeders, growers, millers and bakers for their intended uses as every consumer demand specific wheat quality characteristics for their end products.
The complexity and regulation of repair of alkylation damage to nucleic acids

Abstract DNA damaging agents have been a cornerstone of cancer therapy for nearly a century. The discovery of many of these chemicals, particularly the alkylating agents, are deeply entwined with the development of poisonous materials originally intended for use in warfare. Over the last decades, their anti-proliferative effects have focused on the specific mechanisms by which they damage DNA, and the factors involved in the repair of such damage. Due to the variety of aberrant adducts created even for the simplest alkylating agents, numerous pathways of repair are engaged as a defense against this damage. More recent work has underscored the role of RNA damage in the cellular response to these agents, although the understanding of their role in relation to established DNA repair pathways is still in its infancy. In this review, we discuss the chemistry of alkylating agents, the numerous ways in which they damage nucleic acids, as well as the specific DNA and RNA repair pathways which are engaged to counter their effects.