Miracle-dz/UniFAR-FTUs huggingface dataset:
HEALTH WORKERS’ EXPERIENCE WITH NEEDLE STICK INJURY IN PATIENTS DIAGNOSED WITH HIV/AIDS IN JAKARTA

Introduction. HIV/AIDS is a virus that attacks the human immune system. In this case, experience refers to an event felt by a needle-injected healthcare workers with a diagnosis of HIV/ AIDS. Experience is an expression of expectation from healthcare workers to healthcare workers who have not experienced the incidence of needle injecting patients with a diagnosis of HIV/ AIDS. Health worker’s experience who had been pierced by a patient's needle (needle stick injury) would experience psychological effects such as anxiety, irritation, and guilty feelings. In this study, the participants, which are the healthcare workers, were expected to share information about their first experience when being injected with HIV/AIDS contaminated needle. This study aims to give a meaning in the experience of the healthcare workers who were injected with needle from patients with HIV/AIDS. Method. This study used qualitative method with a descriptive phenomenological approach by involving 5 participants, namely healthcare workers who had worked for more than 4 years. Result. The results were obtained by in-depth interviews and analyzed through the Collaizi method using the NVivo application. The results of the study found 3 (three) themes, the first theme is, Response and adaptation of needle injected HIV/ AIDS patients which generated several categories (psychological, spiritual and social responses) and (psychological, spiritual, and social adaptations). The second theme is the effect of having ARV therapy which causes both physical effects and psychological effects. The third theme is the precautionary measures of HIV/AIDS needle-injected, which consist of preventive and rehabilitative actions. Conclusion: Healthcare services have an obligation to provide support and motivation to healthcare workers who experienced the incidence of being injected by needle from patients with a diagnosis of HIV/AIDS.
A Novel Subset of Triple-Negative Breast Cancers with Unique Histology and Immunohistochemical Expression

Background & Objective: Triple-Negative Breast Carcinoma (TNBC) is characterized by an absence of estrogen receptor, progesterone receptor and HER2 neu expression, with distinct molecular, histological and clinical features, aggressive clinical course and a poor prognosis. The objective was to evaluate the expression of Cytokeratin5/6 (CK 5/6), Epidermal Growth Factor Receptor 1 (EGFR 1), E-cadherin and Androgen receptor in tissue sections of TNBC. Methods: All modified radical mastectomy samples received negative for the three markers were subjected to further studies with CK5/6, EGFR 1, E- cadherin and Androgen receptor staining. The clinical and pathological data were tabulated and statistically analysed using the Chi-square test, and cross-tabulation was done to assess the correlation between these markers. Results: Of 94 samples classified as TNBC, 31 (33%) were positive for CK 5/6, 47 (50%) for EGFR, 32 (34%) for E Cadherin and Androgen receptor, respectively. We had one positive patient for all four markers, 13 patients were negative for all four. Thirty-five cases were positive for only one marker, 32 were positive for two markers, and 13 were positive for three markers. Analysis revealed certain interesting patterns, namely - E cadherin was the most common isolated marker expressed in our cohort of TNBC with 15 of 35 positives. Conclusion: This study highlights the presence of a unique subtype of TNBC, which are negative for all the four markers studied here, with unique histomorphology of absent tumour necrosis and stromal lymphocytic infiltration being unique.
The Long-Term Labor Market Effect of Drought Exposure: Evidence from Nigeria

Abstract This study shows that women’s labour market outcomes in adulthood vary depending on the circumstance that prevails in the early stages of their lives. Exploiting the variation in drought incidences across Nigerian states with a nationally representative household survey for the periods 2008 and 2013, the result shows that women exposed to the drought at early periods of life see adverse labor market outcomes (including the probability of working and the standard of such work). Educational outcomes also declined with exposure to the drought, suggesting that poor human capital formation is a potential channel for these effects. Impacts on a related supplementary outcome, age at marriage entry, is also a consistent operative channel of impact. These findings further shed light on potential labor supply deficits for women from early life exposure to adverse climatic conditions.
International Structural Competitiveness and the Hierarchy in the World Economy

The aim of this paper is to determine the level of competitiveness of national economies and their resulting hierarchy in the world economy. Based on the assumption that there is a structural relationship between the competitiveness of a national economy and the level of its economic development, we identify the main structural factors of international competitiveness. These factors are the degree of diversification of the productive structure of a national economy and the strength of its domestic sectoral productive linkages—which are both related to the level of industrial and technological development and the technological structure of exports. The Technologically Advanced Domestic Value Added in Exports, which condenses the above structural factors, is proposed as a measure of the level of competitiveness of national economies. This measure is implemented in order to determine the hierarchical position of 43 economies in terms of their international competitiveness. In addition, another measure of international competitiveness, the Economic Complexity Index, is examined and tested. When comparing the examined economies’ hierarchical positions obtained by using the two measures, a high correlation and a strong positive linear relationship between them is revealed.
Growth, Yield and Nutrient Uptake of Safflower as Influenced by Inm Under Irrigation and Rainfed Planting

A field experiment on “Growth, yield and nutrient uptake of safflower as influenced by INM under irrigation and rainfed planting” was conducted during rabi , 2013 at College Farm, Rajendranagar, Hyderabad. The experiment was laid out in a split plot design with two main treatments viz., M1: irrigation at rosette, branchingand flowering, M2 : rainfed planting; and seven sub treatments viz., S1 : Control (no fertilizers), S2: RDF, S3: soil test based fertilizers, S4: RDF + FYM @ 5 tons/ha, S5 : soil test based fertilizers + FYM @ 5 tons/ha, S6: RDF + vermicompost @ 2 tons/ha and S7: Soil test based fertilizers + vermicompost @ 2 tons/ha and replicated thrice. With respect to irrigations at critical stages gives higher plant height, dry matter production per plant, seed yield, stalk yield and nutrient uptake were recorded with irrigation treatment and it was significantly higher than rainfed planting. With respect to organics and soil test based inorganic fertilizers gives higher plant height, dry matter production per plant, seed yield, stalk yield and nutrient uptake were recorded with S7 (soil test based fertilizers + vermicompost @ 2 tons/ha) and it was significantly superior to S6 (RDF + vermicompost @ 2 tons ha-1) followed by S5 (soil test based fertilizers + FYM @ 5 tons/ha), S4 (RDF + FYM @ 5 tons/ha), S3 (soil test based fertilizers) and S2 (RDF). Interaction effect of plant height, dry matter production, seed and stalk yield and nutrient uptake of safflower crop as influenced by main and sub treatments were found to be non-significant.
Exploring the Awareness on Green Human Resource Development Practices among Hotel Industry Employees in Lagos State, Nigeria: A Preliminary Study

The purpose of this study is to explore awareness on green human resource development practices among employees of the hotel industry in Lagos State, Nigeria. Over the past decade, the impact from climate change and global warming has led to environmental degradation. This is because of the harmful activities conducted on the natural environment by employees and various organizations, of which the hotel industry is part of. The overconsumption of energy and water, and the use of products and materials which are considered harmful to the environment. Lack of effective waste disposal mechanisms, and the inability to recycle, are all harmful to the environment. Globally, the hotel industry is a major employer of labour, therefore, to help mitigate these harmful practices, there is the need for the hotel industry in Nigeria to adopt green human resource development (Green HRD) practices. This is to help transform the natural environment back to its original state. The method of data collection for the study is structured interview, which is a qualitative study. Two employees working in the same hotel participated in the study. The outcome from the preliminary investigation revealed that, although employees had awareness on what green practices means, but lacked knowledge on green training and development, which is a practices, there is the need to invest on green training and development. Green training and development will help to strengthen the green human capital of the explored hotel, so as to be able to achieve environmental performance. Due to the number of few participants which took part in the study, subsequent researches can focus on a larger number of participants among employees in Nigeria's hotel industry, as this may lead to a broader outcome and perspective.
A Japanese Dose of Prasugrel versus a Standard Dose of Clopidogrel in Patients with Acute Myocardial Infarction from the K-ACTIVE Registry

Background: Dual antiplatelet therapy (DAPT) with aspirin plus P2Y12 inhibitor is used as a standard therapy for patients with acute myocardial infarction (AMI) treated with drug-eluting stents (DESs). In Japan, clopidogrel was the major P2Y12 inhibitor used for a decade until the new P2Y12 inhibitor, prasugrel, was introduced. Based on clinical studies considering Japanese features, the set dose for prasugrel was reduced to 20 mg as a loading dose (LD) and 3.75 mg as a maintenance dose (MD); these values are 60 and 10 mg, respectively, globally. Despite this dose discrepancy, little real-world clinical data regarding its efficacy and safety exist. Methods: From the K-ACTIVE registry, based on the DAPT regimen, patients were divided into a prasugrel group and a clopidogrel group. The ischemic event was a composite of cardiovascular death, non-fatal MI, and non-fatal stroke. The bleeding event was type 3 or 5 bleeding based on the Bleeding Academic Research Consortium (BARC) criteria. Results: Substantially more patients were prescribed prasugrel (n = 2786) than clopidogrel (n = 890). Clopidogrel tended to be selected over prasugrel in older patients with numerous comorbidities. Before adjustments were made, the cumulative incidence of ischemic events at 1 year was significantly greater in the clopidogrel group than in the prasugrel group (p = 0.007), while the cumulative incidence of bleeding events at 1 year was comparable between the groups (p = 0.131). After adjustments were made for the age, sex, body weight, creatine level, type of AMI, history of MI, approach site, oral anticoagulation therapy, presence of multivessel disease, Killip classification, and presence of intra-aortic balloon pumping, both ischemic and bleeding events became comparable between the groups. Conclusion: A Japanese dose of prasugrel was commonly used in AMI patients in the real-world database. Both the prasugrel and clopidogrel groups showed comparable rates of 1 year ischemic and bleeding events.
Effects of Temperature on the Timeliness of eDNA/eRNA: A Case Study of Fenneropenaeus chinensis

Environmental DNA (eDNA) technology has been successfully applied to detect organisms in various aquatic ecosystems. However, eDNA has been proven to exist for a long time in environmental samples. The timeliness of eDNA detection results largely depends on the rate of molecular degradation. Environmental RNA (eRNA) is considered an excellent complementary tool because most researchers believe that RNA degrades faster than DNA in vitro, while, to the best of our knowledge, the number of published articles related to eRNA is very limited. To address an important knowledge gap, this study focused on the response mechanism of eRNA degradation to water temperature change as compared with eDNA. Changes in the concentration of eDNA and eRNA of the mitochondrial cytochrome c oxidase subunit 1 (COI) gene from Fenneropenaeuschinensis were detected at four temperatures (10, 15, 20 and 25 °C). The results showed that the degradation rate of eDNA increased with an increase in temperature. The degradation rate constants ranged from 0.011 to 0.486 h−1 and the degradation time ranged from 8 to 383 h for eDNA. The degradation rate of eRNA changed slightly with an increase in temperature. The degradation rate constants ranged from 0.190 to 0.379 h−1 and the degradation time ranged from 11 to 22 h for eRNA. eRNA showed better stability under temperature change and maintained a faster degradation rate at low temperatures. These results provide answers to the questions of whether eRNA and eDNA degradation rates are fast or slow. Furthermore, this study may suggest the potential superiority of eRNA over eDNA and promote further study of eRNA in future research.
Dampak Pandemi Covid-19 Terhadap Kinerja Perusahaan Farmasi yang terdaftar di BEI

The purpose of the study was to see differences in financial performance before and when the covid-19 virus was first announced in Indonesia, in pharmaceutical companies listed on the IDX. The analytical method used is the Paired Sample T-Test Difference. The population in this study were all pharmaceutical companies listed on the Indonesia Stock Exchange as many as 12 companies. The sample used in this study were 11 companies in the 2019-2021 period consisting of Darya-Varia Laboratoria Tbk (DVLA), Indofarma Tbk (INAF), PT Kimia Farma Tbk (KAEF), Kalbe Farma Tbk (KLBF), Merck Tbk (BRAND), PT Phapros Tbk (PEHA), Pyridam Farma Tbk (PYFA), PT Organon Pharma Indonesia Tbk (SCPI), PT Sido Muncul Herbal and Pharmaceutical Industry Tbk (SIDO), Tempo Scan Pacific Tbk (TSPC), and Millennium Pharmacon International Tbk (SDPC). The results of the study found that there were no differences in financial performance before and during the covid-19 virus in pharmaceutical companies listed on the IDX in terms of liquidity ratios, activity ratios, and profitability ratios. Based on the results of the study, it can be concluded that there is no difference in financial performance before and during the covid-19 pandemic. Abstrak Tujuan Penelitian untuk melihat perbedaan kinerja keuangan sebelum dan saat virus covid-19 pertama kali di umumkan di Indonesia, pada perusahaan Farmasi yang terdaftar di BEI. Metode analisis yang digunakan adalah Uji Beda Paired Sample T-Test. Populasi dalam penelitian ini adalah seluruh perusahaan Farmasi yang terdaftar di Bursa Efek Indonesia yakni sebanyak 12 Perusahaan. Sampel yang digunakan dalam penelitian ini adalah 11 perusahaan pada periode 2019-2021 yang terdiri dari Darya-Varia Laboratoria Tbk (DVLA), Indofarma Tbk (INAF), PT Kimia Farma Tbk (KAEF), Kalbe Farma Tbk (KLBF), Merck Tbk (MERK), PT Phapros Tbk (PEHA), Pyridam Farma Tbk (PYFA), PT Organon Pharma Indonesia Tbk (SCPI), PT Industri Jamu Dan Farmasi Sido Muncul Tbk (SIDO), Tempo Scan Pacific Tbk (TSPC), dan Millennium Pharmacon International Tbk (SDPC). Hasil Penelitian menemukan bahwa tidak terdapat perbedaan kinerja keuangan sebelum dan saat virus covid-19 pada perusahaan farmasi yang terdaftar di BEI ditinjau dari rasio likuiditas, rasio aktivitas, dan rasio profitabilitas. Berdasarkan hasil penelitian maka dapat disimpulkan tidak terdapat perbedaan kinerja keuangan sebelum dan saat pandemi virus covid-19. Kata Kunci: Likuiditas, Aktivitas, Profitabilitas, Kinerja Keuangan
Efficacy of biosynthesizing folate, riboflavin and typical probiotic traits reveal the potential use of \(\textit{Lactobacillus plantarum}\) LCN13 as a feed additive for swine farming

Lactic acid bacteria have been advocated as probiotics to replace antibiotic growth promoters, improve growth performance, and reduce cost production in swine farming. The aim of this study is to identify and evaluate the probiotic traits of strain LCN13 isolated from traditionally fermented feed for swine. Thirty-five bacterial isolates with different morphological characteristics were isolated, among which 9 isolates showed the ability to produce lactic acid and antibacterial activity against pathogenic bacteria. Among them, isolate LCN13 exhibited a strong capacity to produce lactic acid (18.5 ± 0.31 g/L), inhibited gastrointestinal pathogens such as Salmonella typhimurium ATCC 14028 (18.3 ± 1.52 mm), Escherichia coli ATCC 11105 (24.7 ± 2.14 mm), and Staphylococcus epidermidis ATCC 35984 (31.6 ± 2.93 mm), and produced 182 ng/mL folate and 233 ng/mL riboflavin as measured by LC-MS/MS after 24 hours of incubation. Based on morphological, biochemical, and 16S rRNA gene analysis, the isolate LCN13 was identified as Lactobacillus plantarum. Phenotypic analysis revealed that L. plantarum LCN13 showed remarkable resistance to 1.2% ox-bile salt, 2.0 mM H2O2, and pH 3.0. In addition, the ability to produce high levels of folate (253.6 ± 10.7 ng/mL) and riboflavin (312.0 ± 12.2 ng/mL) after 48 hours was exploited for the first time in the L. plantarum. Taken together, L. plantarum LCN13 might serve as a potential probiotic candidate for animal farming.
Establishing Quality of Life in Southern Taiwan COPD Patients Using Long-Acting Bronchodilator

Background To assess the health-related quality of life (HRQoL) of Taiwan patients with different stages of chronic obstructive pulmonary disease (COPD) and using different combination therapies and to explore the factors affecting HRQoL in these patients. Methods This cross-sectional study included outpatient participants aged 35 years old and older who were receiving long-acting bronchodilator treatment in one of two hospitals in Southern Taiwan. Participants were categorized according to their Global Initiative for Obstructive Lung Disease (GOLD) classification as either their COPD group, based on symptoms and exacerbation risk, or their COPD stage, based on spirometry results. Patients’ HRQoL was assessed using the St. George’s Respiratory Questionnaire score (SGRQ), World Health Organization Quality of Life Quality of Life-BREF (WHOQOL-BREF), and EQ-5D-5L. The total scores of the SGRQ, WHOQOL-BREF, EQ-5D utility index, and EQ-VAS were presented as mean ± standard deviation (SD) among different combination treatments. Univariate and multivariate analyses were used to explore the association of patients’ baseline characteristics and environmental factors with HRQoL. Results A total of 218 patients were enrolled in the study. The distribution of patients using GOLD group classification were as follows: 73.39% in group A, 20.19% group B, 1.83% group C and 4.59% group D. Triple therapy patients mostly showed a lower quality of life than other combination therapies, regardless of the GOLD classification system. However, only the SGRQ scores of GOLD groups A and B were significantly different when using different drug combinations (p-value = 0.0072 and 0.0430, respectively). The COPD assessment test (CAT) score, a questionnaire to assess impact of COPD on health status, was found to be associated with all the questionnaires. Conclusion The HRQoL is impaired in patients with COPD, and it deteriorates with an increase of severity. The CAT was the strongest predictor of HRQoL.
Joint User Association and Resource Allocation for Wireless Hierarchical Federated Learning with IID and Non-IID Data

In this work, hierarchical federated learning (HFL) over wireless multi-cell networks is proposed for large-scale model training while preserving data privacy. However, the imbalanced data distribution has a significant impact on the convergence rate and learning accuracy. In addition, a large learning latency is incurred due to the traffic load imbalance among base stations (BSs) and limited wireless resources. To cope with these challenges, we first provide an analysis of the model error and learning latency in wireless HFL. Then, joint user association and wireless resource allocation algorithms are investigated under independent identically distributed (IID) and non-IID training data, respectively. For the IID case, a learning latency aware strategy is designed to minimize the learning latency by optimizing user association and wireless resource allocation, where a mobile device selects the BS with the maximal uplink channel signal-to-noise ratio (SNR). For the non-IID case, the total data distribution distance and learning latency are jointly minimized to achieve the optimal user association and resource allocation. The results show that both data distribution and uplink channel SNR should be taken into consideration for user association in the non-IID case. Finally, the effectiveness of the proposed algorithms are demonstrated by the simulations.
Quercetin exerts an ameliorative effect in the rat model of diclofenac-induced renal injury through mitigation of inflammatory response and modulation of oxidative stress

Diclofenac (DIC) is administrated to treat pain, inflammatory disorders, and dysmenorrhea but kidney problems are the main worries of the agent. The literature has revealed that quercetin (QR) has anti-inflammatory and antioxidant attributes. This study aims to highlight the possible nephroprotective effects of QR on DIC-exposed rats. In this study, the animals after exposure to DIC (50 mg/kg, i.p) were administrated to QR (100 mg/kg, p.o). Then, the levels, as well as the activity of several oxidant and anti-oxidant mediators, were evaluated. Our results showed that DIC treatment was coupled with the elevation in the levels of malondialdehyde (MDA), nitric oxide (NO), and some pro-inflammatory factors such as TNF-α, NF-κB, and IL-1β, suggesting that probably this agent exert its toxicity in the kidney tissue through inducing both oxidative stress and inflammation. Interestingly, QR was successful in restoring the activity of antioxidant compounds such as GSH, GPx, SOD, and CAT in the kidney tissue of DIC-treated rats. Moreover, in the presence of QR, DIC was unable to increase the expression of pro-inflammatory cytokines, suggesting that perhaps QR might have anti-inflammatory properties. In agreement with this, the results of the histopathological evaluation also showed that while DIC increased the lymphocyte infiltration into the kidney tissue, QR reduced the number of lymphocytes in DIC-treated rats. The results revealed that QR exerted a supportive effect against diclofenac-induced renal injury in male rats through modulation of oxidative stress and mitigation of inflammatory response.