Miracle-dz/UniFAR-FTUs huggingface dataset:
Expanding the depth and sensitivity of cross-link identification by differential ion mobility using FAIMS

In cross-linking mass spectrometry, the depth and sensitivity is often limited by the low abundance of cross-links compared to non-cross-linked peptides in the digestion mixture. To improve the identification efficiency of low abundant cross-links, here we present a gas-phase separation strategy using high field asymmetric waveform ion mobility spectrometry (FAIMS) coupled to the Orbitrap Tribrid mass spectrometers. By enabling an additional peptide separation step in gas phase using the FAIMS device, we increase the number of cross-link identification by 23% for a medium complex sample and 56% for strong cation exchange-fractionated HEK293 cell lysate. Furthermore, we show that for medium complex samples, FAIMS enables the collection of single-shot cross-linking data with comparable depth to the corresponding sample fractionated by chromatography-based approaches. Altogether, we demonstrate FAIMS is highly beneficial for XL-MS studies by expanding the proteome coverage of cross-links while improving the efficiency and confidence of cross-link identification.
Employability With Mental Illness: The Perspectives of Employers and Mental Health Workers

Having prior contact with people with mental illness in the workplace can lead to an improvement in employers’ attitudes toward this group. However, there is currently a lack of instruments to measure attitudes toward the employability of people with mental illness. The overall aim of this study was to develop a Spanish scale of attitudes toward the employability of people with mental illness (CEPEM) and obtain preliminary data regarding its psychometric properties. Ninety-four items from three content domains were selected (attitudes, employability, and impact) and revised in an inter-rater agreement procedure in order to produce an initial scale. The scale was tested by employers and workers from the field of mental health. A reduced set of items was selected according to variability and homogeneity indexes. Additional analyses were conducted to explore the validity of the scale. Internal consistency was estimated for the full 33-item scale. Scale scores partially captured attitudinal differences between employers and workers. Finally, linear multiple regression analysis showed that the scale score, in combination with educational level, can help to predict employers’ intentions to hire people with mental illness. Limitations and future research directions are also addressed.
DaRe: Data Recovery Through Application Layer Coding for LoRaWAN

Long-range wide-area network (LoRaWAN) is an energy-efficient and inexpensive networking technology that is rapidly being adopted for many Internet-of-Things applications. In this study, we perform extensive measurements on a new LoRaWAN deployment to characterise the spatio-temporal properties of the LoRaWAN channel. Our experiments reveal that LoRaWAN frames are mostly lost due to the channel effects, which are adverse when the end-devices are mobile. The frame losses are up to 70 percent, which can be bursty for both mobile and stationary scenarios. Frame losses result in data losses since the frames are transmitted only once in the basic configuration. To reduce data losses in LoRaWAN, we design a novel coding scheme for data recovery called DaRe that works on the application layer. DaRe combines techniques from convolutional and fountain codes. By implementing DaRe, we show that 99 percent of the data can be recovered with a code rate of 1/2 when the frame loss is up to 40 percent. Compared to the repetition coding scheme, DaRe provides 21 percent higher data recovery and can save up to 42 percent of the energy consumed on a transmission for 10-byte data units. We also show that DaRe provides better resilience to bursty frame losses.
Fabrication of Ultralow Stress TiO2/SiO2 Optical Coatings by Plasma Ion-Assisted Deposition

Optical and mechanical properties of multilayer coatings depend on the selected layer materials and the deposition technology; therefore, knowledge of the performances of thin films is essential. In the present work, titanium dioxide (TiO2) and silicon dioxide (SiO2) thin films have been prepared by plasma ion-assisted deposition (PIAD). The optical, structural, and mechanical properties of thin films have been investigated using spectrometer/ellipsometer, X-ray diffraction (XRD), atomic force microscopy (AFM), and laser interferometer. The results show that TiO2 film fabricated by PIAD induces a high refractive index, wide optical band gap, amorphous structure, smooth surface, and tensile stress. In the case of SiO2 film, high bias voltage leads to dense structure and compressive stress. As an application, a three-wavelength high reflectance at 632.8, 808, and 1550 nm was optimized and deposited. The dependence of total stress in the multilayer on the substrate temperature was studied as well. In conclusion, it was demonstrated that PIAD is an effective method for the preparation of ultralow stress TiO2/SiO2 multilayer films. The achieved stress was as low as 1.4 MPa. The result could provide guidance to the stress optimization of most optical components without prefiguring, backside coating, and postdeposition treatments.
An analysis of user behaviors on the search engine results pages based on the demographic characteristics

The purpose of this survey-based study is to make an analysis of search engine users’ behaviors on the Search Engine Results Pages (SERPs) based on the three demographic characteristics gender, age, and program studying. In this study, a questionnaire was designed with 12 closed-ended questions. Remaining questions other than the demographic characteristic related ones were about “tab”, “advertisement”, “spelling suggestion”, “related query suggestion”, “instant search suggestion”, “video result”, “image result”, “pagination” and the amount of clicking results. The questionnaire was used and the data collected were analyzed with the descriptive statistics as well as the inferential statistics. 84.2% of the study population was reached. Some of the major results are as follows: Most of each demographic characteristic category (i.e. female, male, under-20, 20-24, above-24, English computer engineering, Turkish computer engineering, software engineering) have rarely or more click for tab, spelling suggestion, related query suggestion, instant search suggestion, video result, image result, and pagination. More than 50.0% of female category click advertisement rarely; however, for the others, 50.0% or more never click advertisement. For every demographic characteristic category, between 78.0% and 85.4% click 10 or fewer results. This study would be the first attempt with its complete content and design. Search engine providers and researchers would gain knowledge to user behaviors about the usage of the SERPs based on the demographic characteristics.
Organizational culture processes for promoting innovation in small businesses

PurposeThe purpose of this study was to examine the contribution of organizational culture processes aimed at promoting innovation in small businessesDesign/methodology/approachThe empirical study was conducted in Israel on a sample of 202 businesses in face-to-face interviews.FindingsThe study demonstrated that small businesses in the industry sectors that seek to promote innovation must implement processes for developing an innovation culture. Interestingly, these processes contribute mainly to product and process innovation and less to marketing and organizational innovation.Practical implicationsThe study may contribute in a practical manner to assisting small businesses in the development and implementation of appropriate organizational culture processes for promoting innovation, and as a result, contribute to overall economic growth.Originality/valueThis research expands the body of knowledge on organizational culture processes for promoting innovation in this group of businesses, which has rarely been the focus of studies on innovation. The use of face-to-face interviews as a research tool facilitated obtaining knowledge that is generally not readily accessible.
Ramadan 2020 and Beyond in the Midst of the COVID-19 Pandemic: Challenges and Scientific Evidence For Action

Background: Ramadan is a sacred month in Islam, which involves 29–30 days of dawn-till-dusk dry-fasting. Millions of Muslims observed Ramadan fasting (RF) this year in the midst of the COVID-19 pandemic. Certain ethnic groups worldwide, including Muslims, have been disproportionately affected by COVID-19, raising fears that fasting could bring additional health risks. This directly impacted on the current challenges faced by health professionals. The COVID-19 virus is expected to become seasonal. Therefore, the evidence presented in this review is valid beyond Ramadan as intermittent fasting is practiced more widely, irrespective of religion, throughout the year as a therapeutic and prophylactic means for several conditions. Methods: A wide range of literature databases were searched for the effects of RF and intermittent fasting on human health and then linked to COVID-19 impact to generate the evidence. Results: This review presents a body of evidence proving RF is safe and beneficial for healthy people who adopt a balanced diet, drink plenty of fluids, and engage in regular physical activity. Fasting reduces levels of pro-inflammatory cytokines (IL-1β and IL-6), which are associated with severe COVID-19. Furthermore, increased handwashing and hygiene during Ramadan may reduce infection risks. For some, social isolation, physical inactivity, reduced access to food and stress – linked to the pandemic – may minimize the benefits that is achieved during a “normal” Ramadan. Conclusions: RF during the COVID-19 pandemic is not a cause of concern for healthy people. However, people who are ill are exempt from fasting and should seek medical advice if they wish to fast. RF during the COVID-19 pandemic is a unique experience and future research will reveal its impact on human health. Key words: COVID-19; Ramadan; fasting; health; mental; exercise; isolation; lockdown; diabetes; biomarkers
Anomalous Pressure Effects on the Electrical Conductivity of the Spin Crossover Complex [Fe(pyrazine){Au(CN)2}2]

We studied the spin-state dependence of the electrical conductivity of two nanocrystalline powder samples of the spin crossover complex [Fe(pyrazine){Au(CN)2}2]. By applying an external pressure (up to 3 kbar), we were able to tune the charge transport properties of the material from a more conductive low spin state to a crossover point toward a more conductive high spin state. We rationalize these results by taking into account the spin-state dependence of the activation parameters of the conductivity.
Analysis of Unequal Distribution of Population Income in Indonesia

Income inequality is a problem that is not only faced by developing countries such as Indonesia, but also developed countries. The difference lies in the proportion of an inequality that occurs and the solution to the level of difficulty experienced. Thus, this study aims to empirically analyze the unequal distribution of population income in Java island, Indonesia, by including the human development index, open unemployment rate, foreign investment, and the degree of fiscal decentralization. The research model used in this study was multiple linear regression to analyze the panel data with a fixed-effect model approach. The results of the study showed that human development index, open unemployment rate, and the degree of fiscal decentralization had a positive and significant effect on income inequality in Java island. Meanwhile, foreign investment had a negative and insignificant effect on income inequality in Java. It is because the value of the investment is more invested in the capital-intensive sector. The government is expected to be more selective in accepting foreign investments that enter the country, especially in Java, and it should be labor-intensive investments. In addition, the government has to equalize locations for foreign investment without reducing good cooperation with these foreign investors.
The Effects of the COVID-19 Pandemic Through the Lens of the CDS Spreads

In this paper we are analysing the impact of the general lockdown measures imposed in Italy in the context of the COVID-19 pandemic on European banks’ CDS spreads. Compared to the impact of the COVID-19 pandemic on sovereign risk, we find little evidence of increased bank risk following the event. However, investors’ reaction was clearly negative in longer time frames. In addition, we quantify the feedback loop between sovereign and bank risk and document an increased interconnectedness between sovereigns and banks during the current health crisis, however with a smaller magnitude comparing to the sovereign debt crisis. Banks are now more resilient to shocks, being a direct consequence of the post-crisis regulatory framework.
Effects of Dietary Protein Levels on Bamei Pig Intestinal Colony Compositional Traits

Diets containing different crude protein levels (16%, 14%, and 12%) were created to feed Bamei pigs in order to study the effect of these compositions on intestinal colonies. Therefore, 27 healthy Bamei pigs of similar weight (20.99 kg ± 0.16 kg) were selected and randomly divided into three groups for microbial diversity analysis. The results of this study show that microbial diversities and abundances in Bamei pig jejunum and caecum samples after feeding with different dietary protein levels were significantly different. Dietary crude protein level exerted no significant effect on the Shannon index for cecum microbes in these pigs, while Simpson, ACE, and Chao1 indices for group I were all significantly higher than those of either the control group or group II (P < 0.05). Indeed, data show that microbial diversities and abundances in the 14% protein level group were higher than those in either the 16% or 12% groups. Dominant bacteria present in jejunum and cecum samples given low-protein diets were members of the phyla Firmicutes and Bacteroidetes. Data show that as dietary crude protein level decreases, representatives of the microbial flora genus Lactobacillus in jejunum and cecum samples gradually increases. Values for the KEGG functional prediction of microbial flora at different dietary protein levels also show that genes of jejunum and cecum microorganisms were mainly enriched in the “metabolism” pathway and indicate that low protein diets increase intestinal metabolic activity. Therefore, we recommend that Bamei pig dietary protein levels are reduced 2% from their existing level of 16% crude protein. We also suggest that essential synthetic amino acids (AA) are added to optimize this ideal protein model as this will increase intestinal flora diversity in these pigs and enhance health. These changes will have a positive effect in promoting the healthy growth of Bamei pigs.
The Role of Toxoplasma gondii Infection Among Multiple Sclerosis Patient Compared to Ordinary People in South of Iran: A Case-Control Study

Background: Toxoplasmosis is a common parasitic disease, which leads to serious disease symptoms in immunocompromised hosts and infants. Recent epidemiologic surveys showed that microbial agents may be associated with some cases of multiple sclerosis (MS). Objectives: This case-control study aimed to examine the role of Toxoplasma gondii in MS by evaluating sero-frequency of anti-T. gondii IgG (ATXAb) antibody between patients with MS and ordinary people in Shiraz Province, south of Iran during 2016 - 2018. Methods: Serum samples obtained from MS patients (n = 130), and a group of age and gender-matched controls (n = 130) with the same socioeconomic status with the patients’ group were collected to evaluate the prevalence of T. gondii IgG antibodies (ATXAb). Moreover, the presence of the ATXAb antibody of the patients and controls was determined by the ELISA test. SPSS 20 software was used to perform the statistical analysis (SPSS, inc., Chicago, USA). Results: Out of 130 (35.4%) cases with MS and 130 (13.8%) controls, 46 and 18 subjects were seropositive for ATXAb, respectively. Based on the chi-square test, a significant difference was observed in terms of the positivity rates of ATXAb between the MS patient group and the control group (P = 0.001). The mean ± standard deviation ATXAb levels in controls and MS patients were found to be 61 ± 34 and 114 ± 47 IU/mL, respectively. Also, there were statistically significant differences between the levels of these two groups (P = 0.001). Conclusions: Given the relationship between toxoplasmosis and MS, it is possible that the prevalence of MS decreases by increasing hygiene and preventing toxoplasmosis.
A retrospective analysis of ectopic pregnancies in tertiary care hospital of Western India: two year study

Background: Ectopic pregnancy (EP) is the leading cause of maternal morbidity and mortality in the first trimester and major cause of reduced reproductive potential. Early detection of EP by improved ultrasonography modalities has decreased the rate of rupture and consequent maternal morbidity. Aim was to study the predisposing risk factors in modern scenario and choose the appropriate management available.Methods: A retrospective study on clinical diagnosis and management of EP of patients was carried out between January 2018 to February 2020. Investigations included CBC, UPT, serum β-hCG and TVS. Management was decided after thorough evaluation.Results: Out of 7,780 deliveries, 70 were EP (0.9%). Women with age 21-30 year had highest incidence (85.7%). Common symptoms were abdominal pain (94%), amenorrhea (87%), bleeding per vagina (48%). Most common risk factor associated with EP was PID (28.5%). Tubal EP was most common (84.2%) involving ampulla (66%), isthmus (15%), fimbria (12%), interstitial (7%). Scar ectopic was reported in 10% of cases and ovarian, rudimentary horn and abdominal pregnancy in 1.4% each. About 52.8% of ectopic was ruptured and salpingectomy was done in 74.3% and salpingo-oophorectomy in 2.8%. Five cases of scar EP required hysterotomy and 1 case was managed by methotrexate (MTX). Conclusions: EP remains a major challenge to the obstetrician worldwide. A high index of suspicion is required for early diagnosis and timely intervention in the form of medical or surgical treatment will definitely help in reducing the morbidity and mortality.
State Segmentation and Democratic Survival in Latin America

Popular models portray that high inequality induces elites to sponsor coups and reverse democratization as a means for repressing redistributive demands. Challenging this prediction, Latin America shifted from a historical pattern of systematic democratic breakdowns to one characterized by the resilience of democracy despite extreme levels of inequality. This article argues that the reminiscence of state-led repression under democracy explains why elites more regularly waive coups as solutions to distributive conflict in Latin American democracies. I call this state segmentation, a concept that describes the asymmetries between the enforcement of citizenship rights for those in privileged positions and for the poor. Wherever state segmentation is high, the odds of democratic breakdown should be lower. I test the argument using logistic regression models to predict the probability of coups and mandate interruptions considering different levels of state segmentation in Latin America using V-Dem data. Results show that asymmetries in access to citizenship rights indeed prevent democratic breakdowns.
The Effectiveness of a Fully Gamified Programming Course after Combining with Serious Games

Our online programming language courses have been developed for youngsters who are interested in computer programming. The courses were gamified with some common gamification elements: points, badges, incentives, immediate feedback and leaderboard. The developed Learning Management System (LMS) for our learning portal provides the chance to monitor all users’ activities. After examining our registered users’ progress in the courses, we tried to increase the effectiveness of the courses (C+, C# and Java) with developing educational game programs that cannot only foster motivation during the playing process but provide faster understanding, since students play with what they need to learn and understand. We compared the performance of the last 200 students who registered and completed the last chapter in the curriculum before the game programs had been added into the Java course, and the first 200 students, who registered and completed the last chapter in the curriculum, after the addition of the games in the supported coding tasks. The results were impressive and proved that with our thematic didactic game programs, users were able to solve coding tasks more effectively.
Regional Flexible Surge Capacity—A Flexible Response System

Surge capacity is the ability to manage the increased influx of critically ill or injured patients during a sudden onset crisis. During such an event, all ordinary resources are activated and used in a systematic, structured, and planned way to cope with the situation. There are, however, occasions where conventional healthcare means are insufficient, and additional resources must be summoned. In such an event, the activation of existing capabilities within community resources can increase regional surge capacity in a flexible manner. These additional resources together represent the concept of Flexible Surge Capacity. This study aims to investigate the possibility of establishing a Flexible Surge Capacity response system to emergencies by examining the main components of surge capacity (Staff, Stuff, Structure, System) within facilities of interest present in the Western Region of Sweden. Through a mixed-method and use of (A) questionnaires and (B) semi-structured key-informant interviews, data was collected from potential alternative care facilities to determine capacities and capabilities and barriers and limitations as well as interest to be included in a flexible surge capacity response system. Both interest and ability were found in the investigated primary healthcare centers, veterinary and dental clinics, schools, and sports and hotel facilities to participate in such a system, either by receiving resources and/or drills and exercises. Barriers limiting the potential participation in this response system consisted of a varying lack of space, beds, healthcare materials, and competencies along with a need for clear organizational structure and medical responsibility. These results indicate that the concept of flexible surge capacity is a feasible approach to emergency management. Educational initiatives, drills and exercises, layperson empowerment, organizational and legal changes and sufficient funding are needed to realize the concept.