Miracle-dz/UniFAR-FTUs huggingface dataset:
SETD7 Expression Is Associated with Breast Cancer Survival Outcomes for Specific Molecular Subtypes: A Systematic Analysis of Publicly Available Datasets

Simple Summary Breast cancer is the most common cancer among women, and it can be classified into subtypes with distinct biology and prognosis. The aim of our bioinformatic study was to assess the potential role of the protein methyltransferase SETD7 in breast cancer by using freely available resources. We saw that SETD7 is differentially expressed across subtypes, which may determine how SETD7 modulates cancer cell biological processes in each subtype. This translates into different prognosis and therapeutic response in patients stratified according to SETD7 levels. SETD7 might provide valuable additional information for discriminating patients based on subtypes and improve therapeutic decisions. Abstract SETD7 is a lysine N-methyltransferase that targets many proteins important in breast cancer (BC). However, its role and clinical significance remain unclear. Here, we used online tools and multiple public datasets to explore the predictive potential of SETD7 expression (high or low quartile) considering BC subtype, grade, stage, and therapy. We also investigated overrepresented biological processes associated with its expression using TCGA-BRCA data. SETD7 expression was highest in the Her2 (ERBB2)-enriched molecular subtype and lowest in the basal-like subtype. For the basal-like subtype specifically, higher SETD7 was consistently correlated with worse recurrence-free survival (p < 0.009). High SETD7-expressing tumours further exhibited a higher rate of ERBB2 mutation (20% vs. 5%) along with a poorer response to anti-Her2 therapy. Overall, high SETD7-expressing tumours showed higher stromal and lower immune scores. This was specifically related to higher counts of cancer-associated fibroblasts and endothelial cells, but lower B and T cell signatures, especially in the luminal A subtype. Genes significantly associated with SETD7 expression were accordingly overrepresented in immune response processes, with distinct subtype characteristics. We conclude that the prognostic value of SETD7 depends on the BC subtype and that SETD7 may be further explored as a potential treatment-predictive marker for immune checkpoint inhibitors.
Probiotics’ Efficacy in Preventing Asthmatic Allergic Reaction Induced by Air Particles: An Animal Study

Global air pollution and diesel exhaust particles (DEPs) generated by intratracheal instillation aggravate asthma. In this study, we evaluated the effect of probiotics via tracheal- or oral-route administration on allergies or asthma. We continuously perfused rats daily, using the oral and tracheal routes, with approximately 106–108 CFU probiotics, for 4 weeks. During this period, we used OVA-sensitized rats to build the asthma models. We orally or intratracheally administered Lactobacillus paracasei 33 (LP33) to the rats, which reduced the number of total inflammatory cells, lymphocytes, and eosinophils in the bronchoalveolar-lavage fluid, the IgE concentration, and the cytokine levels of TH2 cells, but we found no significant difference in the cytokine levels of TH1 cells. LP33 can be used to prevent asthmatic allergic reactions induced by aerosol particles. Nevertheless, the dosage form or use of LP33 needs to be adjusted to reduce the irritation of lung tissues, which may produce lesions of the trachea. We observed that DEP dosage can alleviate emphysema, and that LP33 has a substantial effect on improving or slowing allergic asthma.
Giant field enhancement at carbon nanotube tips induced by multistage effect

Recently, we have reported an extremely strong field emission from carbon nanotubes grown on carbon cloth, with the field-enhancement factor of up to 18 800. In this paper, we study the origins of this effect, by investigating field emission from individual carbon nanotubes, in a transmission electron microscope equipped with a piezo manipulator. Microscopic analysis reveals a multistage structure of some of the nanotubes, characterized by an order of magnitude smaller nanotubes branching off the tips of bigger nanotubes (or carbon fibers). The multistage structure causes a macroscopic enhancement of the electric field, which can match that of a single macroscopically long nanotube with length equal to the combined length of all stages, and the tip radius equal to that of the thinnest nanotube in the structure. This not only explains the observed giant field enhancement, but also provides important clues for the design of nanotube emitters for electronic applications.
Metal–Organic Frameworks as Potential Agents for Extraction and Delivery of Pesticides and Agrochemicals

Pesticide contamination is a global issue, affecting nearly 44% of the global farming population, and disproportionately affecting farmers and agricultural workers in developing countries. Despite this, global pesticide usage is on the rise, with the growing demand of global food production with increasing population. Different types of porous materials, such as carbon and zeolites, have been explored for the remediation of pesticides from the environment. However, there are some limitations with these materials, especially due to lack of functional groups and relatively modest surface areas. In this regard, metal–organic frameworks (MOFs) provide us with a better alternative to conventionally used porous materials due to their versatile and highly porous structure. Recently, a number of MOFs have been studied for the extraction of pesticides from the environment as well as for targeted and controlled release of agrochemicals. Different types of pesticides and conditions have been investigated, and MOFs have proved their potential in agricultural applications. In this review, the latest studies on delivery and extraction of pesticides using MOFs are systematically reviewed, along with some recent studies on greener ways of pest control through the slow release of chemical compounds from MOF composites. Finally, we present our insights into the key issues concerning the development and translational applications of using MOFs for targeted delivery and pesticide control.
Functional Near-Infrared Spectroscopy of English-Speaking Adults With Attention-Deficit/Hyperactivity Disorder During a Verbal Fluency Task

Objective: Functional near-infrared spectroscopy (fNIRS) provides direct and quantitative assessment of cortical hemodynamic response. It has been used to identify neurophysiological alterations in medication-naïve adults with attention-deficit/hyperactivity disorder (ADHD). Hence, this study aimed to distinguish both medication-naïve and medicated adults with ADHD from healthy controls (HC). Method: 75 HCs, 75 medication-naïve, and 45 medicated patients took part in this study. fNIRS signals during a verbal fluency task (VFT) were acquired using a 52-channel system and relative oxy-hemoglobin changes in the prefrontal cortex were quantified. Results: Prefrontal cortex hemodynamic response was lower in patients than HCs (p ≤ ≤.001). Medication-naïve and medicated patients did not differ in hemodynamic response or symptom severity (p > .05). fNIRS measurements were not associated with any clinical variables (p > .05). 75.8% patients and 76% HCs were correctly classified using hemodynamic response. Conclusion: fNIRS may be a potential diagnostic tool for adult ADHD. These findings need to be replicated in larger validation studies.
Flux and source term discretization in two‐dimensional shallow water models with porosity on unstructured grids

Two‐dimensional shallow water models with porosity appear as an interesting path for the large‐scale modelling of floodplains with urbanized areas. The porosity accounts for the reduction in storage and in the exchange sections due to the presence of buildings and other structures in the floodplain. The introduction of a porosity into the two‐dimensional shallow water equations leads to modified expressions for the fluxes and source terms. An extra source term appears in the momentum equation. This paper presents a discretization of the modified fluxes using a modified HLL Riemann solver on unstructured grids. The source term arising from the gradients in the topography and in the porosity is treated in an upwind fashion so as to enhance the stability of the solution. The Riemann solver is tested against new analytical solutions with variable porosity. A new formulation is proposed for the macroscopic head loss in urban areas. An application example is presented, where the large scale model with porosity is compared to a refined flow model containing obstacles that represent a schematic urban area. The quality of the results illustrates the potential usefulness of porosity‐based shallow water models for large scale floodplain simulations. Copyright © 2005 John Wiley & Sons, Ltd.
The Impact of a CMV Infection on the Expression of Selected Immunological Parameters in Liver Tissue in Children with Biliary Atresia

The pathogenesis of biliary atresia (BA) is still not clear. The aim of this study was to evaluate the expression of selected immunological parameters in liver tissue in BA children based on CMV/EBV infection status. Eight of thirty-one children with newly diagnosed BA were included in this prospective study and assigned to two groups (I with active infection, II without active or past infection). All studies were performed on surgical liver biopsies. To visualize CD8+ T cells and CD56 expression, immunohistochemical staining was performed. The viral genetic material in the studied groups was not found, but CMV infection significantly affected the number of CD8+ lymphocytes in both the portal area and the bile ducts. The average number of CD8+ cells per mm2 of portal area in Groups I and II was 335 and 200 (p = 0.002). The average number of these cellsthat infiltrated the epithelium of the bile duct per mm2 in Group I and II was 0.73 and 0.37 (p = 0.0003), respectively. Expression of CD56 in the bile ducts corresponded to the intensity of the inflammatory infiltrate of CD8+ cells. Our results suggest that active CMV infection induces an increased infiltration of CD8+ lymphocytes, which could play a role in BA immunopathogenesis. Increased CD56 expression can be a sign of a newly formed bile structure often without lumen, suggesting inhibition of the maturation process in BA.
Aerodynamic characteristics of NACA 0012 airfoil section at angles of attack from 0 degrees to 180 degrees

Report presenting the aerodynamic characteristics of the NACA 0012 airfoil section at a range of angles of attack from 0 to 180 degrees. Data were obtained at two different Reynolds numbers depending on whether the airfoil surfaces were smooth or had roughness applied at the leading and trailing edges. After the stall with the rounded edge of the airfoil foremost, a second lift-coefficient peak was obtained at an angle of attack of about 45 degrees.
OPTICAL PROPERTIES OF THERMALLY EVAPORATED METAL-FREE PHTHALOCYANINE (H2Pc) THIN FILMS

The optical properties of metal-free phtalocyanine (H2Pc) in thin film form is investigated. X-ray diffractograms of the (H2Pc) powder show that it has a α-polycrystalline form with a monoclinic structure. The thermal evaporation of (H2Pc) powder leads to α-polycrystalline films, oriented preferentially to the (001) plane. After annealing at 623 K for two hours, a mixture of α- and β-phases is formed on an amorphous background. The optical properties of (H2Pc) thin films have been studied using spectrophotometeric measurements of transmittance and reflectance in the range 200–2200 nm for a different film thickness. The refractive index and the absorption index show independence on the film thickness. The refractive index shows anomalous dispersion in the region of the fundamental absorption edge. The absorption measurements show the characteristic splitting of the Q-band and ΔQ is obtained as 0.22 eV. The absorption coefficient in the absorption region reveals indirect transitions. The fundamental and the onset energy gap are determined as 2.74 eV and 1.55 eV, respectively.
Training on integrated science learning for science teachers in Nekamese District

PKM activities are carried out in partner schools in the form of training for Mathematics and Natural Sciences teachers to overcome the problems they are facing. Some of the obstacles that are being faced are that science teachers still have difficulty applying integrated science learning according to the demands of the 2013 curriculum. The targets to be achieved in the implementation of this PKM program include increasing the professional competence of teachers in implementing integrated science learning. Activities are designed in several stages, namely 1) coordinating with partner schools for implementation time, 2) providing material related to integrated science learning, 3) Mentoring for Natural Sciences teachers in designing integrated science material and 4) program evaluation. This activity was not only attended by Natural Sciences teachers in partner schools but several Natural Sciences teachers in schools around partner schools were also joined. Participants in the activity were Natural Sciences teachers from SMP N 1 Nekamese, SMP N 2 Nekamese, SMP N 4 Nekamese, and SMP N 5 Nekamese. The participants were quite enthusiastic in participating in this activity, seen from the enthusiasm for joining the activity and dynamic discussions
Management of Upper Limb Amputation Rehabilitation

Abstract Upper limb amputation can result in significant functional impairment necessitating a comprehensive rehabilitation approach throughout the continuum of care. In 2022, the Departments of Veteran Affairs and Defense completed an updated clinical practice guideline for the management of upper limb amputation rehabilitation. This practice guideline was developed by a workgroup of subject-matter experts from a variety of disciplines. Twelve key questions were developed by the workgroup using the PICOTS (population, intervention, comparator, outcomes, timing of outcomes measurement, and setting) format to establish the scope of the literature review. Eighteen recommendations were developed through extensive review of the available literature and use of the Grading of Recommendations, Assessment, Development and Evaluation criteria. The strength of each recommendation was determined based on the quality of the research evidence and the additional domains of the Grading of Recommendations, Assessment, Development and Evaluation criteria. Of the 18 recommendations, 4 were found to have sufficient evidence to suggest for use of a particular rehabilitation management strategy. Thus, the 2022 Department of Veteran Affairs and Department of Defense clinical practice guideline provides updated, evidence-based information on the care and rehabilitation of persons with upper limb amputation. However, a significant lack of high-quality evidence in upper limb amputation rehabilitation limited evidence-based clinical guidance to assist healthcare providers in managing this population.
Breast cancer in elderly patients: a clinicopathological review of a Nigerian database

Background Breast cancer in the elderly population has not been evaluated in the Nigerian context. With the rising incidence of breast cancer and the changing demographics, it is likely that an increasing number of elderly patients will be managed in the coming years in Nigeria. This review describes the clinicopathological profile of elderly patients with breast cancer in a Nigerian database. Method From a prospective institutional database, elderly patients (65 years and above) managed for breast cancer over a 9-year period were reviewed. Details of their socio-demographic characteristics, patterns of presentation, pathology, treatment and outcome were obtained and analysed. Results Of the 607 patients managed during the study period, there were 87 older patients accounting for 14.3% of the total. There was a progressive rise in the number of patients with breast cancer towards the latter part of the study. Expectedly, they were all post-menopausal, with their ages ranging from 65 to 92 years, with a mean of 71 ± 6.58 years. Systemic hypertension was the commonest co-morbidity (29.8%). The mean tumour size at presentation was 10 cm, with the majority presenting with stage 3 disease. Invasive ductal carcinoma was the predominant histological type 83 (95.4%); 44.4% of those who had immunohistochemistry were oestrogen receptor-positive. Approximately half underwent mastectomy (52.8%), 63 (72.4%) had chemotherapy, 8 (44.4%) had hormonal therapy and only 6 (6.9%) had combined multimodal therapy in addition to surgery. Overall 5-year survival was 42.1%. Conclusion The pattern of presentation and outcomes of care in this elderly cohort is similar to the general population. Early presentation and use of multimodal treatment is still the mainstay of survival.
Spectral synthesis in the ultraviolet. II. Stellar populations and star formation in blue compact galaxies

An initial attempt to apply optimizing spectral synthesis techniques to the far-UV spectra of blue compact galaxies (BCGs) is presented. The far-UV absorption-line spectra of the galaxies are clearly composite, with the signatures of the main-sequence types between O3 and mid-A. Most of the low-ionization absorption lines have a stellar origin. The Si IV and C IV features in several objects have P Cygni profiles. In Haro I the strength of Si IV indicates a significant blue supergiant population. The metal-poor blue compact dwarf Mrk 209 displays weak absorption lines, evidence that the stellar component has the same low metallicity as observed in the ionized gas. Good fits to the data are obtained the technique of optimizing population synthesis. The solutions yield stellar luminosity functions which display large discontinuities, indicative of discrete star formation episodes or bursts. The amount of UV extinction is low. 97 references.
The Effectiveness of a Four-Week Online Mindfulness Training Course on Individual Mindfulness Skills and Personal Perception of Stress in Company Employees Working from Home

Working from home comes with many benefits. However, employees are often exposed to various stressors when working outside of the traditional workplace environment. The subjective experience of these stressors is related to one’s perception of the situation and the perceived resources available. As working from home has become the new normal for many during the COVID-19 pandemic, it is in the interest of companies to provide employees with tools to cope with these stressors. One such tool is online mindfulness training. This study investigates how a four-week online mindfulness training influences an individual’s mindfulness skills, subjective perception, and processing of stressors. Forty participants working from home at the time of the study were examined in a pre-test using a pre-post design in which the experimental group participated in a four-week online training course in mindfulness. Since the results showed a significantly reduced subjective perception of stress in the experimental group after mindfulness training, a long-term study was conducted including 40 additional participants. The study revealed a training success of at least three months. It thus introduces new possibilities for effective stress management in all workplace settings.
Intrinsic features of flow around two side-by-side square cylinders

The wake of two side-by-side square cylinders is investigated in detail based on flow visualization at a Reynolds number (Re) of 300. The cylinder center-to-center spacing ratio T* (= T/W, W is the cylinder width) is varied from 1.0 to 5.0. The intrinsic features of the wake are explored, including the gap vortices, flow switch, stability, merging of two streets into one, etc. The qualitative information on these features is further complemented by the quantitative information extracted from hotwire data at Re = 4.7 × 104 using both spectral and cross-wavelet analyses. Four flow regimes are identified: (i) the single bluff body regime (T* 2.4). The gap flow is found to switch at two distinct time scales, referred to as macro and micro switches. Macro switch occurs at 1.2 < T* < 2.1, where the gap flow is slim in width and biased for a long duration ranging.
Magnetic field instabilities in accretion disks

The stability of magnetic fields within the accretion disks is examined, including the effects of magnetic buoyancy. Rayleigh-Taylor, and Kelvin-Helmholtz instabilities. The purpose of the study is to examine the efficacy of turbulent accretion (.cap alpha.-) disk models which depend upon ''magnetic viscosity'' to provide the dissipation necessary to account for radial infall. We provide estimates for the time scales of the dominant instabilities in both the gas pressure-dominated and radiation pressure-dominated regions of a thin accretion disk; provide constraints on dynamo processes such that ''magnetic viscosity'' operates to permit stationary accretion; show that field amplification may take place even in vertically stably stratified regions of a thin disk by the action of ''magnetic buoyancy-driven'' convection; and demonstrate that the turbulent Reynolds stress responsible for accretion is proportional to the gas pressure even in the radiation-dominated portion of the disk (so that the disk is stable to viscous and thermal instabilities). Furthermore, we show that if a ''seed'' magnetic field is injected into a thin accretion disk, then the formation of buoyancy-generated hot corona above the disk appears inevitable.
Churinet—Applying Deep Learning for Minor Bodies Optical Navigation

This article presents Churinet, a hybrid neural network-based method, devoted to on-board spacecraft relative position and attitude estimation in the vicinity of minor bodies such as asteroids, comets or small moons, using monocular vision. In the context of navigating such minor bodies, traditional heuristic methods for spacecraft position and attitude determination encounter limitations in robustness and precision in the presence of adverse illumination conditions. Moreover, its performance is limited due to the computational cost resulting from the evaluation of a large number of possible pose hypotheses. In comparison, Churinet solves the relative pose estimation problem by directly learning the nonlinear transformation from a 2-D grayscale image to the 6-D pose vector space. Churinet is confirmed by a set of sequential convolutional neural networks (CNNs) organized in two levels. The high-level multiclass-classification CNN is in charge of determining the sector of the discretized 3-D space. Then, based on the sector estimation, the image is ingested by a low-level regression CNN, trained specifically for that sector, which estimates the pose of the camera. The secondary contribution of this research is the development of SPyRender, a tool for the generation of large sets of synthetic images, suitable for the training and testing of the designed CNNs. SPyRender implements GPU-accelerated physically based rendering, enabling the efficient generation of photorealistic images. SPyRender has been used with the 3-D model of comet 67P/C-G for producing multiple image sets covering the whole range of camera position, attitude, and illumination conditions, allowing us to study the impact of different geometries and image effects in the network performance.