Miracle-dz/UniFAR-FTUs huggingface dataset:
The Effects of Home-based Responsive Teaching Curriculum on Interactional Behaviors of Mothers and Their Children with Autism Spectrum Disorder: A Mixed Design Study in Turkey

The effectiveness of Responsive Teaching (RT) Early Intervention Program which is one of the relationship-focused interventions (RFI) on five children diagnosed with autism spectrum disorder (ASD) and their mothers was studied. The study was conducted in “Mixed Research Design” in which both quantitative and qualitative data were collected. Quantitative data of the study were collected through single group pretest-posttest model and qualitative data were collected from field notes, diaries, video analyses and interviews. Findings gathered from pretest and posttest quantitative results revealed that the RT program was effective on interactive behaviors of five children with ASD and their mothers. Qualitative results supported the quantitative findings and revealed that mothers stated they became more sensitive and responsive to their children behaviors by using RT strategies.
OBSTACLES TOWARDS TRANSLATING A KUWAITI PUBLIC SECTOR STRATEGY INTO ACTION: EVIDENCE FROM KUWAIT

Purpose–The aim of this study is to empirically investigate barriers towards successful strategy formulation and implementation in the public sector strategy of Kuwait. Design/methodology/approach – The article used a questionnaire survey to identify the barriers toward successful strategy formulation and implementation experienced by the public sector organizations. The questionnaires were distributed to 300 public sector employees, from which 200 were valid for analysis. Participants were requested to state the degree of agreement with the items listed in the questionnaire. Regression analysis employed to identify factors impact strategy formulation and implementation. Findings – The study showed that unsuccessful strategies formulation and implementation result from various aspects of government institutions (organization, policies and regulations, human resources and communications). The participants revealed that lack of consensus among decision makers, lack of effective role formulators and lack of choice of real strategy formulators represent major obstacle toward strategies formulation. Incompatible structure with the strategy and insufficient linkage between strategy and goals were the main variables that prevent successful strategies implementation. The regression analysis pointed to policies and regulations, communication and external factors as the most significant determinants of strategy formulation; whereas organizational and communication factors appeared to be the most significant determinant of strategy implementations. Research limitations – Specific governmental departments were targeted by the questionnaire survey employed in this study. This reflect the staff employed in these departments. To obtain a wide picture about strategy implementation, the Ministry of Planning and the Ministry of Finance should be surveyed since they are responsible of a significant part of the country's strategic planning. Practical implications– This research offers valuable practical insights of decision maker. it might provide the route map for the firm and develop a good information system that help managers for obtaining the highest quality of knowledge through developing processes, systems and managerial mechanisms. obstacles,
ATTENTIONAL FACTORS IN EASTER EGGS CHOICE BY CHILDREN

O mercado voltado para criancas continua crescendo ao longo dos anos. No entanto, algumas permanecem pouco exploradas. Ovos de Pascoa e um exemplo. A estrategia de marketing e oferecer diferentes tipos de brinquedos ou ter um personagem popular na embalagem. Este artigo tem como objetivo compreender quais fatores em um ovo de Pascoa atraem mais atencao: brinquedos, personagens ou sabor. Um eyetracker foi usado para identificar a atencao e a fixacao do olhar durante a exploracao das imagens. Quarenta criancas, com idade entre sete e dez anos, participaram do experimento. Os resultados mostraram que os ovos de chocolate classicos foram preferidos tanto pela escolha quanto pelo tempo medio de fixacao, sugerindo que o sabor e um criterio de escolha prevalente.
Identifying key regulators of the immune/inflammatory response for developing anticonvulsive and antiepileptogenic approaches

Epilepsy therapy is based on drugs that treat the symptoms, seizures, rather than the disease. There are no treatments for modifying the course of the disease, improving prognosis. Another unmet need is the absence of biomarkers able to identify patients at risk of developing epilepsy or with a progressive disease. Among the potential pathways for attaining these unmet needs, we focused on neuroinflammation since it is a pathological process occurring in experimental epileptogenesis and in human epilepsy. Interleukin-1β (IL-1β)/IL-1Receptor type 1 (IL-1R1) and High Mobility Group Box 1 (HMGB1)/Toll-like Receptor 4 (TLR4) axes are key initiators of neuroinflammation following epileptogenic injuries. Experimental and clinical evidence showed that endogenous anti-inflammatory mechanisms are not efficiently activated in epileptogenic tissue. Among these mechanisms, we focused on specialized mediators driving the process of “resolution of inflammation”. We demonstrated that induction of pro-resolving response is delayed during epileptogenesis compared to activation of neuroinflammation. Based on this, we studied the antiepileptogenic and disease-modifying effects of two pharmacological strategies aimed at (1) anticipating and boosting resolution of neuroinflammation by enhancing pro-resolving mechanisms and (2) blocking the neuroinflammatory response with a combined anti-inflammatory treatment targeting IL-1β/IL-1R1 and HMGB1/TLR4 pathways. (1) The pro-resolving treatment decreased neuroinflammation, ameliorated cognitive deficits and reduced spontaneous seizure frequency and duration; (2) the combined anti-inflammatory treatment prevented disease progression. The role of HMGB1 and its isoforms was investigated in epileptogenesis and drug-resistance. In two animal models of epileptogenesis the pathologic disulfide HMGB1 isoform progressively increased in blood before epilepsy onset, and prospectively identified animals that developed the disease. Moreover, the combined anti-inflammatory approach prevented disease progression and the increase in HMGB1 isoforms in blood during epileptogenesis. In conclusion, pro-resolving and anti-inflammatory treatments have disease-modifying effects and HMGB1 isoforms are potential mechanistic biomarkers for epileptogenesis, underlying the need of validation in prospective clinical studies.
Can scare tactics and fear-based messages help deter substance misuse: a systematic review of recent (2005–2017) research

Abstract Introduction: Historically, substance use prevention relied heavily on scare tactics and fear-based messages. However, these messages were discouraged from use due to research finding them ineffective or harmful. This review sought to determine if recent research continues to support this finding. Methods: We conducted a literature review of relevant peer-reviewed studies from 2005 to 2017, categorising results as showing clear evidence of effectiveness, mixed evidence of effectiveness or no evidence of effectiveness. Research on historical scare tactics and fear-based messages was reviewed as a baseline and research on related theoretical models was reviewed for context. Results: We identified 17 studies that met our inclusion criteria: 10 targeting tobacco use, five targeting alcohol use, one targeting marijuana use and one targeting methamphetamine use. Eight (8) studies found that these messages were more effective at influencing substance use-related measures than positive emotion prevention messages or control messages. Five (5) studies found mixed evidence, and four (4) studies found no evidence of effectiveness. Discussion: Though not conclusive, our results suggest that these messages may be more effective than previously shown. However, many of the studied messages differed in tone and content from similar, historical messages. Organizations interested in implementing these messages should note these differences.
Evaluation of burnout in medical interns: an institutional study

Background: Burnout is a psychological syndrome characterised as state of emotional exhaustion, negative attitude towards the recipient of care (depersonalisation) and a feeling of low accomplishments in human service professionals. However, there is very limited literature about Burnout syndrome among medical interns from India. Thus, this study aimed to found out the prevalence of burnout syndrome among medical interns and to find any gender differences between male and female interns. Methods: The study was a cross sectional study with a convenient sample of 100 medical Interns. Subjects filled a pretested semi-structured questionnaire, which consisted of demographic data and measures of assessment. Burnout was assessed by application of Masalach Burnout Inventory. Definition of burnout was taken as high score (>27 points) on Emotional exhaustion subscale, along with high scores (>10 points) on depersonalization subscale and Low score (<33 points) on personal accomplishment subscale. Results: Mean age of the sample was 23.9 years. 48 % were males and 52% were females. Burnout syndrome was found to be present in 22% subjects. 34% scored High on Emotional exhaustion subscale, while 46% scored High on depersonalization subscale and 77% scored Low on personal accomplishment subscale. Burnout status and subscales scores did not vary significantly with gender. Conclusions: Considering the higher ratings on various domains of Burnout among medical interns there is a need for targeted action and further research for a healthy workforce development in field of Medical care.
Factors Affecting the Financial Performance of Companies Based on Agency Theory

insider company insider try their with company's Abstract: This study examines the factors that influence a company's financial performance based on agency theory. There were 5 independent variables used in this study, namely institutional ownership, insider ownership, board size, company size, and debt ratio, as well as the dependent variable, namely the company's financial performance measured using Tobin's Q ratio. This study used a quantitative approach using multiple linear regression analysis methods with a sample of 357 non-financial companies listed on the Indonesia Stock Exchange over the 2013-2017 period. Data processing used Eviews, where the results showed that institutional ownership, insider ownership, board size, company size, and debt ratio simultaneously had a significant positive effect on Tobin's Q. However, if the variables were tested separately, it was found that institutional ownership, insider ownership, and debt ratio had a significant positive effect on Tobin's Q, while firm size had a significant negative effect on Tobin's Q and board size had no significant effect on Tobin's Q.
The Effect of Superstars on Game Attendance: Evidence From the NBA

Economic models predict that “superstar” players generate externalities that increase attendance and other revenue sources beyond their individual contributions to team success. We investigate the effect of superstar players on individual game attendance at National Basketball Association games from 1981-1982 through 2013-2014. Regression models control for censoring due to sellouts, quality of teams, unobservable team/season heterogeneity, and expected game outcomes. The results show higher home and away attendance associated with some superstar players. Michael Jordan generated the largest superstar attendance externality, generating an additional 4,837/4,236 fans at home/away games.
Working condition and work-life balance of working women in a tertiary care hospital in a metropolitan city of Tamil Nadu: a cross sectional study

Workplace health promotion has been defined as the combined efforts of employers, employees and society to improve the health and well-being of people at work and focuses on the factors associated with safe, motivating and enjoyable work settings. According to Brooks, quality of life is improving the work experience of employees and increasing the overall productivity. Work-life balance is defined as the “extent to which individuals are equally engaged in and equally satisfied with work and family roles. " Employee satisfaction is about providing them with place where they feel accepted, wanted and appreciated. The married employed women play several roles as a parent, as a spouse, as a responsible daughter, as a conscious citizen along with her role in workplace. Lot of time and productive energy, also commitment is required to fulfil the responsibilities. ABSTRACT
Preliminary design of organic fluid turbines to predict the efficiency

Turbine efficiency plays a key role in the design optimization of ORCs (organic Rankine cycles) and should be properly evaluated for an accurate estimate of the real power production. Most of the literature focuses on cycle configuration, design parameters and working fluid that maximize different performance metrics, but often ignores the expander design features that are necessary to obtain them, by fixing in advance the expander efficiency. This approach is questionable for ORC systems where the high volumetric expansion ratios, variable sizes and working fluids may markedly affect turbine efficiency. This work focuses on the preliminary design of radial inflow turbines and single stage axial flow turbines operating with different organic fluids. The aim is to build general efficiency maps in accordance with the similarity principles for the performance prediction of turbines having very different design specifications (i.e., mass ow rate and enthalpy drop) and handling different working fluids. The so-called “size parameter” (SP) and the volumetric expansion ratio (VR) are identified as the best efficiency predictors for ORC turbines. The former is proportional to the turbine size and accounts for the scale effect, i.e. the detrimental effect on the performance when the machine is scaled down below a certain size; the latter accounts for the compressibility influence and, compared to the pressure expansion ratio, limits the influence of the fluid properties. Mean-line models are built for the preliminary design and performance estimation of radial and axial turbines in the Matlab ® environment implementing recent loss correlations to account for the flow irreversibilities and real fluid properties evaluated using the Refprop database. These models are used to simulate the turbine behavior and generate new design charts relating the efficiency to the design parameters (i.e., specific speed and velocity ratio for radial turbines; loading coefficient and flow coefficient for axial turbines). Several simulations are then carried out to generate the optimum designs for a wide range of design specifications and working fluids, and the associated efficiency maps in the SP-VR plane. These maps show that neither the size effect (SP), nor the compressibility effect (VR) have a negligible influence on the turbine performance: the efficiency increases as SP increases and VR decreases. Despite the general efficiency trends in the SP-VR maps are similar, differences due to the fluid effect exist. So, the critical temperature of the working fluid is proposed as third efficiency predictor and a general correlation between turbine efficiency and size parameter, volumetric flow ratio, critical temperature is obtained. The resulting generalized efficiency map is conceptually valid for any fluid and can be easily integrated into a comprehensive thermodynamic cycle optimization procedure to account for the real turbine performance and overcome the limitations due to a separate design of turbine and system.
Histopathological changes caused by accidental avocado leaves toxicity in rabbits

Avocado is one of the common fruits in the state of Mizoram, India. Though the fruit is loaded with various nutrients, leaves are highly toxic to rabbits. Dead male Chinchilla rabbits (2 months old) died due to ingestion of avocado leaves was the subject of the present study. On post-mortem examination, pathological changes like severe congestion and petechiation of liver, infarction of kidney and congestion of myocardium were observed. Histopathological changes include hepatic degeneration with severe congestion, degeneration of kidney tubular epithelial cells with congestion in the interstitium and degeneration and fragmentation of myocardial cells.
Individual patients data analysis (IPD) of three randomized studies comparing erlotinib (E) with chemotherapy (CT) in patients with advanced wild-type epidermal growth factor receptor (wtEGFR) non-small cell lung cancer (NSCLC).

8048 Background: While the benefit of EGFR tyrosine kinase inhibitors in EGFR mutated NSCLC patients (pts) is undisputed, their usefulness in wtEGFR pts is still questioned. The TAILOR, DELTA and PROSE trials singularly showed a significant gain in Progression-Free Survival (PFS) favoring CT. We present here the mature results from the IPD analysis of the three studies. Methods: In each trial, pts with wtEGFR stage IIIB/IV NSCLC, progressing after first line platinum-based therapy, were randomized 1:1 to receive either E or CT at standard doses. Primary endpoints of this IPD were PFS and Overall Survival (OS); summary measures were Hazard Ratio (HR) and Difference in Mean Survival Time (DMST), which is the difference in the areas under the Kaplan-Meier curves of two treatment arms. Cox regression analyses were used to estimate the HR. All analyses were stratified by trial. Results: The analysis included all 587 pts randomized into the trials (Overall E/CT 303/284; TAILOR 109/110; DELTA 109/90; PROSE 85/84.
Are energy drinks suitable for children?

In January 2018, Jamie Oliver made national headlines with a new campaign calling for a ban on ‘energy drinks’ sales to children younger than 16 years due to concerns about the caffeine and sugars content of these beverages. Following the campaign launch, the retailer Waitrose announced that it would not sell these products to children younger than 16 years, and subsequently numerous retailers (ASDA, Aldi, Boots, Co-op, Morrisons, Sainsbury’s and Tesco) and even a town (St. Martins, Shropshire) have followed suit. So far, movement to restrict sales by retailers is voluntary, with no legal requirement to do so. However, the response by retailers raises the question: are energy drinks suitable for children to consume?
An Integrated Approach to Treatment of Chronic Low Back Pain: Based on Neuroscience of Pain

The high recurrence rate and prevalence rate of chronic low back pain causes work incapacity and increases the cost of both medical resources and the economic burden on society. The incidence of low back pain is about 84%, with a high recurrence rate and prevalence rate [1]. Low back pain has been considered as a kind of disability [2]. Treatments are mainly focused on decreasing pain through traction and exercise, but with only shortterm effects. Chronic fascial low back pain is a common muscularskeletal disorder, and is categorized according to the source of pain: muscle, ligament, and soft tissue-related, neurological, joint-related, and other [3]-[4]. There are 65% of patients with muscle-related low back pain. Muscle-related low back pain is considered an early stage of the disorder, and has potential of reversal. Pain recurrence would lead to dysfunction, decrease in quality of life, increased consumption of social resources, and loss of productivity may be inevitable.
Relationship between the values of blood parameters and physical status in Korean native calves with diarrhea

Dehydration, electrolyte disturbance, and acid-base imbalance are the most significant consequences of diarrhea in calves. We aimed to determine blood gas, hematological, electrolyte, and biochemical values and investigate the relationship between the physical status and blood parameters in Korean native calves (KNCs) with diarrhea. One hundred eighty KNCs with diarrhea (age < 75 days) were investigated. Blood samples were collected from the external jugular vein and analyzed using a portable clinical blood gas analyzer. The measured parameters were statistically compared according to the status of physical activity, dehydration, or prognosis. The mean values of parameters in the Calves with diarrhea showed metabolic acidosis, hyponatremia, and azotemia. The mean values of potassium, chloride, hematocrit, and hemoglobin were in the upper limit of their reference ranges. More than 75% of the calves had metabolic acidosis caused by bicarbonate loss, and 63.6% had high blood urea nitrogen (BUN) values. Moreover, BUN showed the highest correlation with the physical activity status and dehydration. pH, base excess of the extracellular fluid (BE), anion gap, potassium, hematocrit, bicarbonate, and hemoglobin were closely correlated with physical deterioration and dehydration (p < 0.001). BUN, pH, BE, and anion gap were closely correlated with physical deterioration and dehydration. These correlations between clinical symptoms and blood gas parameters can be clinically relevant in predicting the status of parameters according to clinical symptoms.
At‐sea intercomparison of three underway pCO2 systems

Ocean surface partial pressure of carbon dioxide (pCO2) is a key factor controlling air–sea CO2 fluxes. Most surface pCO2 data are collected with relatively large and complex air–water equilibrators coupled to stand‐alone infrared analyzers installed on Ships of OPportunity (SOOP‐CO2). This approach has proven itself through years of successful deployments, but expansion and sustainability of the future measurement network faces challenges in terms of certification, autonomy, and maintenance, which motivates development of new systems. Here, we compare performance of three underway pCO2 measurement systems (General Oceanics, SubCtech, and Pro‐Oceanus), including a recently developed compact flow‐through, sensor‐based system. The systems were intercompared over a period of 34 days during two crossings of the subpolar North Atlantic Ocean. With a mean difference from the General Oceanics system of −5.7 ± 4.0 μatm (Pro‐Oceanus) and −4.7 ± 2.9 μatm (SubCtech) during the 1st crossing, our results indicate potential for good agreement between the systems. The study highlighted the challenge of assuring accuracy over long periods of time, particularly seen in a worse agreement during the 2nd crossing, and revealed a number of sources of systematic errors. These can influence accuracy of the measurements, agreement between systems and include slow response of membrane‐based systems to pCO2 changes, “within‐ship” respiration due to biofouling, and bias in measurement of the temperature of equilibration. These error sources can be controlled or corrected for, however, if unidentified, their magnitude can be significant relative to accuracy criteria assigned to the highest‐quality data in global databases. The advantages of the compact flow‐through system are presented along with a discussion of future solutions for improving data quality.