Miracle-dz/UniFAR-FTUs huggingface dataset:
OARRR_A_268852 203..206

1Division of Rheumatology, Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Ondokuz Mayis University, Samsun, Turkey; 2Department of Pulmonary Medicine and Tuberculosis, Faculty of Medicine, Ondokuz Mayis University, Samsun, Turkey Introduction: Data from clinical trials indicate that there are no increased risk of tuberculosis (TB) infections in rheumatoid arthritis (RA) patients while using rituximab (RTX). Herein, we report a RA patient who developed TB arthritis while using RTX. Case Report: A 49-year-old patient was treated with methotrexate and prednisolone along with RTX for two years. Later, she presented with increasing pain, swelling, redness and cutaneous fistulization in her left wrist for two months. The lesion on the wrist was debritted. Histopathologic evaluation revealed the presence of acid-fast bacilli. Polymerase chain reaction test and culture confirmed mycobacterium tuberculosis. RTX, methotrexate and prednisolone were withdrawn. The patient was treated with 12-month course of antituberculous treatment and responded well. The patient, who did not have pain or swelling in her other joints, was not given any treatment for RA after antituberculous treatment. Conclusion: Clinicians should keep in mind that TB infections may be encountered while using RTX. Latent TB screening may be appropriate in patients using concomitant corticosteroid and living in TB endemic areas.
OPTO_A_232487 73..81

1Materials Science Department & COMiB Research Centre in Optics and Optometry, University of Milano-Bicocca, Milano, Italy; 2Institute of Research and Studies in Optics and Optometry (IRSOO), Vinci, Italy Abstract: The developmental eye movement (DEM) test is a practical and simple method for assessing and quantifying ocular motor skills in children. In this review, a summary of the literature relevant to the DEM test has been made, its psychometric properties and its pros and cons have also been considered. The DEM test provides clinicians with a simple method of measuring eye movement using a psychometric test. Over the years, many studies have enabled the identification of the strengthens and weaknesses of this test apart from outlining the psychometric properties. The validity of the test has been checked and expanded over time and studies have shown that the DEM test measures an aspect of eye movement related to reading, rather than purely parameters associated with eye-movement. Some reservations have emerged regarding the repeatability of the test because a degree of learning effect emerges over multiple sessions. Being aware of this point allows correct clinical application and interpretation of the test. Normative data in children were available for nine languages and countries. So far, DEM test could be applied clinically in each case when a rapid test of eye movement was required, such as in testing for vision-related visual problems.
IFNβ therapy against EAE is effective only when development of the disease depends on the NLRP3 inflammasome

Interferon-β (IFN-β) is widely used to treat multiple sclerosis (MS), and its efficacy was demonstrated in the setting of experimental autoimmune encephalomyelitis (EAE), an animal model of MS; however, IFN-β is not effective in treating all cases of MS. Here, we demonstrate that signaling by IFNAR (the shared receptor for IFN-α and IFN-β) on macrophages inhibits activation of Rac1 and the generation of reactive oxygen species (ROS) through suppressor of cytokine signaling 1 (SOCS1). The inhibition of Rac1 activation and ROS generation suppressed the activity of the NLRP3 inflammasome, which resulted in attenuated EAE pathogenicity. We further found that two subsets of EAE could be defined on the basis of their dependency on the NLRP3 inflammasome and that IFN-β was not an effective therapy when EAE was induced in an NLRP3 inflammasome–independent fashion. Thus, our study demonstrates a previously uncharacterized signaling pathway that is involved in the suppression of EAE by IFN-β and characterizes NLRP3-independent EAE, which cannot be treated with IFN-β.
DEV106336 1..11

Embryonic heart formation requires the production of an appropriate number of cardiomyocytes; likewise, cardiac regeneration following injury relies upon the recovery of lost cardiomyocytes. The basic helix-loop-helix (bHLH) transcription factor Hand2 has been implicated in promoting cardiomyocyte formation. It is unclear, however, whether Hand2 plays an instructive or permissive role during this process. Here, we find that overexpression of hand2 in the early zebrafish embryo is able to enhance cardiomyocyte production, resulting in an enlarged heart with a striking increase in the size of the outflow tract. Our evidence indicates that these increases are dependent on the interactions of Hand2 in multimeric complexes and are independent of direct DNA binding by Hand2. Proliferation assays reveal that hand2 can impact cardiomyocyte production by promoting division of late-differentiating cardiac progenitors within the second heart field. Additionally, our data suggest that hand2 can influence cardiomyocyte production by altering the patterning of the anterior lateral plate mesoderm, potentially favoring formation of the first heart field at the expense of hematopoietic and vascular lineages. The potency of hand2 during embryonic cardiogenesis suggested that hand2 could also impact cardiac regeneration in adult zebrafish; indeed, we find that overexpression of hand2 can augment the regenerative proliferation of cardiomyocytes in response to injury. Together, our studies demonstrate that hand2 can drive cardiomyocyte production in multiple contexts and through multiple mechanisms. These results contribute to our understanding of the potential origins of congenital heart disease and inform future strategies in regenerative medicine.
EXTREME WAVE RUN-UP ON A VERTICAL CLIFF

Wave impact and run-up onto vertical obstacles constitutes one of the main phenomena which have to be taken into account in the design of coastal structures. From the linear wave theory we know that the wave height on a vertical wall is twice the incident wave amplitude. Weakly nonlinear theories bring some small corrections to this result. However, in the present study we show that certain simple wave groups may produce much higher run-ups ever predicted by previous theoretical investigations. Consequently, the results presented in this study can be considered as a note of caution for practitioners, on one side, and as a challenging novel material for theoreticians who work in the ﬁeld of the wave/structure interaction.
Auditory Manifestations and Intervention in Children with Autism Spectrum Disorders

Children with Autism Spectrum Disorder (ASD) often have associated auditory manifestations, such as hyperacusis, difficulty hearing in background noise, and Auditory Processing Disorders (APD). Physiological and neuroanatomical changes in the auditory pathway and the non-classical auditory pathway, including the limbic system and the autonomic nervous system, are known to underlie these auditory deficits. This paper reviews the most common auditory manifestations in children with ASD and discusses the neuroanatomical evidence and the electrophysiological findings that have been used to identify changes in neural processing associated with auditory disorders in ASD. In addition, this paper provides an overview of auditory assessment and its challenges, and discusses intervention strategies for auditory problems in children with ASD.
The Combination of an In ammatory Peripheral Blood Gene Expression and Imaging Biomarkers Enhance Prediction of Radiographic Progression in Knee Osteoarthritis

Mukundan Attur (  mukundan.attur@nyulangone.org ) NYULOH https://orcid.org/0000-0001-7080-8118 Svetlana Krasnokutsky NYU Langone Health Hua Zhou NYU Langone Health Jonathan Samuels NYU Langone Health Gregory Chang NYU Langone Health Jenny T. Bencardino Hospital of the University of Pennsylvania Pamela Rosenthal NYU Langone Health Leon Rybak NYU Langone Health Janet L. Huebner Duke University School of Medicine Virginia B. Kraus Duke University School of Medicine Steven B. Abramson NYU Langone Health
HMBD and 5-AzadC combination reverses tumor suppressor CCAAT/enhancer binding protein delta to strengthen the death of liver cancer cells

Institute of Bioinformatics and Biosignal Transduction, National Cheng Kung University, Taiwan Department of Pathology, Chi-Mei Medical Center, Taiwan PhD program for Neural Regenerative Medicine, Taipei Medical University, Taiwan Department of Pharmacology, National Cheng Kung University, Taiwan Division of Hematology/Oncology, Department of Internal Medicine, National Cheng Kung University Hospital, Taiwan Institute of Basic Medical Sciences, National Cheng Kung University, Taiwan Division of Molecular and Genomic Medicine, National Health Research Institutes, Taiwan Graduate Institute of Medical Sciences, Taipei Medical University, Taiwan
Twenty years results of the radial artery as a coronary artery bypass conduit

Background: There is lack of evidence for the choice of the second conduit in coronary surgery. The radial artery (RA) is a possible option but few data on its very long term outcome exist. Objective: To describe the twenty-year results of RA grafts used for coronary artery bypass grafting and the long term effects of RA removal on forearm circulation. Methods: We report the results of the prospective 20 years follow‐up of the first 100 consecutive patients who received the RA as a coronary bypass conduit at our Institution. Results: Follow-up was 100% complete. There were 64 deaths, 23 (35.9%) from cardiovascular causes. Kaplan-Meier twenty years survival was 31%. Thirty-three of the 36 survivors (91.6%) underwent RA graft control at a mean of 19.0 ± 2.5 years after surgery. The RA was found patent in 24 cases (84.8% patency). In the overall population patency graft probability at 10 and 20 years was 95.1±2.7 at both intervals for the left internal thoracic artery (ITA), 90±3.1 and 65.4±7.7 for the RA and 71±5.3 and 29.4±6.4 for the saphenous vein (SV) (p= .001 for RA vs SV, .006 for RA vs ITA and <.0001 for ITA vs SV). When the target vessel stenosis was ≥ 90% RA patency rate was similar to that of the ITA. No patients reported hand or forearm symptoms. The diameter of the ulnar artery was increased in the operated arm (2,44 ± 0,43 mm vs 2,01 mm ± 0,47 mm, p<0.05) and correlated with the peak systolic velocity of the second palmar digital artery (Pearson’s coefficient 0.621, p<0.05). Conclusion: The 20‐year patency rate of RA grafts is good and is similar to that of the ITA for >90% target vessel stenosis. RA harvesting does not lead to hand or forearm symptoms even at a very long term follow-up.
Value of Matrix metalloproteinase-7and Vimentin as Prognostic Biomarkers in Adenoid Cystic Carcinoma (Immunohistochemical Study)

Background: matrix metalloproteinase-7 (MMP7), its primary role is to break down extracellular matrix including casein, type I, II, IV, and V gelatins, fibronectin, and proteoglycan. The upregulation of MMP7 is associated with many malignant tumors. Vimentin (Vim) plays an important role in malignant tumors with regard to cellular adhesion, migration and signaling. In our current study, we have attempted to evaluate the expression of MMP7 and Vim as markers for aggressive biological behavior of AdCC. Materials and Methods: Nineteen formalin fixed paraffin embedded blocks of AdCC were collected retrospectively were included in this study. An immunohistochemical (IHC) staining was performed using anti MMP7 and anti Vim monoclonal antibodies. Results: MMP7 showed significant relation with larger size tumor (P=0.003), higher grade (P=0.006). The Vim was significantly correlated with minor salivary gland (P=0.041), larger size tumor (P=0.021), high grade (P=0.040). Both markers revealed highly significant correlation with advanced stage (P<0.001), and positive lymph node (LN) (P<0.001). There was a significant positive correlation between Vim and MMP7 (P=0.001). Conclusion: Both MMP7 and Vim are positively correlated with tumors of poor prognosis.
CMAR_A_304686 3101..3111

1Department of General, Minimally Invasive and Endocrine Surgery, Wroclaw Medical University, Wroclaw 50-556, Poland; 2Department of Nervous System Diseases, Faculty of Health Science, Wroclaw Medical University, Wroclaw 51-618, Poland; 3Department of Pathomorphology, Wroclaw Medical University, Wroclaw 50-368, Poland Purpose: Although some prognostic variables and risk factors for thyroid cancer (TC) are age-related, the association between age and the risk of TC in patients with thyroid nodules (TNs) assigned to atypia of undetermined significance (AUS) and follicular lesion of undetermined significance (FLUS) is poorly estimated. The aim of this study was to assess the histopathology of AUS/FLUS and the risk of TC according to the age of the patients at the time of AUS/FLUS diagnosis. Patients and Methods: Among 5021 individuals treated for TNs at one institution from 2008 to 2018, 161 (3.2%) patients with 161 TNs assigned to the AUS/FLUS category (1 nodule per patient) were selected and stratified by age at initial diagnosis: <55 years, 55–75 years and >75 years. Logistic regression analysis was used to estimate the association of age with the risk of TC diagnosis. Results: Ninety-one (56.52%) patients <55 years old, 58 (36.02%) patients 55–75 years old, and 12 (7.45%) individuals >75 years old were identified. There were 130 (80.7%) females and 31 (19.3%) males with a mean age of 50.6 ± 16.12 years. Among the evaluated TNs, 142 (88.2%) were ultimately diagnosed as benign, and 19 (11.8%) were diagnosed as malignant. Younger age in patients was significantly related to malignancy outcome (p=0.024 for age <55 years). Patients aged 55–75 years had a significantly lower risk of TC than the other age categories (p=0.040). The risks of high vascularity and fast tumor growth were significantly higher in the youngest category than in the other categories (age <55 years old: p=0.045 and p=0.002, respectively). Conclusion: Although patients with TNs classified as AUS/FLUS by ultrasound-guided fine needle aspiration biopsy (UG-FNAB) are not typically qualified for surgery, it is worth noting that younger patients with an AUS/FLUS diagnosis might be at a higher risk of TC.
Can man-made visible light radiation affect the reproductive capacity of male mice ?

The present study aimed to evaluate the effects of isothermal non-ionizing electromagnetic field (EMF), represented by the man made visible light, on the reproductive capacity of mice. Male mice were exposed to artificial visible light (intensity of 77 mW/cm 2 on the area of 72.5 cm 2 and frequency of EM radiation between 3.9 x10 14 Hz and 7.5 x10 14 Hz W/cm 2 ) eight hours/day for 5, 7, and 15 days. The present results indicated that exposure of male mice to visible light for five or seven days showed dramatic alterations in the histological architecture of the testis, moreover, exposure for 15 days induced a complete degeneration of germ and Sertoli cells. Gonadotropic hormones levels; FSH and LH were signifycantly declined by Day 5 and were not detected absolutely at days 7 and 15. In general, immunoreactivity of spermatogonia to proliferating cell nuclear antigen (PCNA) decreased in exposed mice. Moreover, germ cell apoptosis assessed by in situ terminal transferase-mediated end labelling (TUNEL) increased significantly in 5 days exposed mice and highly increased in 7 days exposed mice compared with controls. Bcl-2 and Bax proteins increased after exposure. Additionally, tumour necrosis factor-alpha (TNF-α) protein content decreased significantly in germ cells after exposure. The present investigation indicated that there is a strong coincidence between the effects of man-made EMF on gonadotropic hormone level expressions and the occurrence of apoptosis in the testis. These data suggest that the man-made EMF interferes with stages of spermato-genesis by disruption of pituitary gland function. In conclusion, man-made visible light radiation affects negatively on the reproductive capacity of male mice.
Pre-proof Metabolic reprogramming and the role of mitochondria in polycystic kidney disease

Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a slowly progressive disease characterized by the relentless growth of renal cysts throughout the life of affected individuals. Early evidence suggested that the epithelia lining the cysts share neoplastic features, leading to the definition of PKD as a “neoplasm in disguise”. Recent work from our and other laboratories has identified a profound metabolic reprogramming in PKD, similar to the one reported in cancer and consistent with the reported increased proliferation. Multiple lines of evidence suggest that aerobic glycolysis (a Warburg-like effect) is present in the disease, along with other metabolic dysfunctions such as an increase in the pentose phosphate pathway, in glutamine anaplerosis and fatty acid biosynthesis, while fatty acid oxidation and oxidative phosphorylation (OXPHOS) are decreased. In addition to glutamine, other amino acid-related pathways appear altered, including asparagine and arginine. The precise origin of the metabolic alterations is not entirely clear, but two hypotheses can be formulated, not mutually exclusive. First, the polycystins have been recently shown to regulate directly mitochondrial function and structure either by regulating Ca uptake in mitochondria at the Mitochondria Associated Membranes (MAMs) of the Endoplasmic Reticulum, or by a direct translocation of a small fragment of the protein into the matrix of mitochondria. One alternative possibility is that metabolic and mitochondrial dysfunctions in ADPKD are secondary to the deregulation of proliferation, driven by the multiple signaling pathways identified in the disease, which include mTORC1 and AMPK among the most relevant. While the precise mechanisms underlying these novel alterations identified in ADPKD will need further investigation, it is evident that they offer a great opportunity for novel interventions in the disease.
Fast Self-Stable Planar Bipedal Running

Bipedal running gaits may be self-stable if they rely on the intrinsic system dynamics to attenuate deviations. This use of passive dynamics for gait stability has been observed in biological running and applied for running robotics, supported with the results of numerical simulations. It is an important aspect of the development of fast and agile legged robotic locomotion over complex terrain. One part of running stability, trunk stabilization, can be described using a virtual pendulum model. We believe such a metacentric model may be applied in robotic design to achieve passive stabilization of body pitch for fast bipedal running. In this study, we test metacentric models for self-stabilization of body pitch in bipedal running and evaluate the effects of running speed, design parameter variations, and control strategies. We extract data from experiments with the Planar Elliptical Runner and compare these with a planar spring-loaded inverted pendulum model with a trunk (TSLIP). We find passive self-stable gaits in the TSLIP model with the centre of mass below the hip. These gaits demonstrate robustness to disturbances and do not require inertial measurements or high-gain feedback control. At high velocities, foot placement and choice of leg stiffness become less critical for gait stability. Data from experiments with the Planar Elliptical Runner support the findings from the model behaviour as it runs reliably, with passively stable body pitch, and without feedback control. A metacentric model, such as the virtual pendulum model, may explain the observed passive body-pitch stabilization. Evidence from the model ground reaction forces suggests that pitch stability for the Planar Elliptical Runner can also be explained with a metacentric model. Stability in height and velocity can be explained with the compliant leg behaviour in stance. Constructing a metacentre through mechanical design is beneficial to intrinsic body-pitch stability and subsequently facilitates full gait self-stability in fast running robotics. Implicit feedback allows off-loading of high-gain feedback control onto the system mechanical design, thus contributing to developments for fast legged locomotion over rough terrain.
REDISTRIBUTIVE EFFECTS OF SOCIAL SECURITY REFORM

This paper analyses the general equilibrium implications of reforming pay-as-you-go pension systems in an economy with heterogeneous agents, human capital investment and capital-skill complementarity. It shows that increasing funding delivers in the long run higher physical and human capital and therefore higher output, but also higher wage and income inequality. The latter affects preferences over the degree of redistribution of e remaining pay-as-you-go component: despite the greater role that edistribution could perform in the new steady state, we find a preference for lower redistribution for a larger group of the population. JEL Code: H55 J31.
A Systematic Review on Supply Chain Management in Prefabricated House-Building Research

Prefabricated house-building companies, as suppliers or supply chains, which use manufacturing as a business approach towards industrialization, struggle to implement principles and optimal practices driven from well-established and validated theories in operational research. Supply chain management has a mature body of knowledge that has been widely adopted by research on offsite construction to improve its performance at an organisational level. However, there is no comprehensive review available in the literature for supply chain management theory within prefabricated house building research from the perspective of suppliers. In this study, a systematic review was conducted on the available literature on supply chain management within prefabricated house-building research. Initially, qualitative analysis was performed to identify the key themes. Later, quantitative analyses were applied to validate the overlapping themes and keywords. Further, key trends related to focus, methods and theories or frameworks were reported. The findings were discussed in the context of recent developments in all principal component bodies of supply chain management for future work. This study also provides a brief guide for potential future review studies to explore interdisciplinary intervention within the offsite stream.