Miracle-dz/UniFAR-FTUs huggingface dataset:
789-793-Yuming Xu-masseter-2

The purpose of this study is to obtain normative va lues of the masseter muscle of myasthenia gravis (MG) patients and healthy volunteers by sing le-fiber electromyography (SFEMG). Stimulation of SFEMG in the masseter muscle was stu died in 15 healthy volunteers (men 8, women 7; mean age 40.2, range 21-77) and 30 patient s affected by MG (men 16, women 14; mean age 42.8, range 12-75). The mean consecutive d ifference (MCD) of the individual fiber and the mean MCD per study were determined in the norma l group. We recommend the upper normal limit for the individual fibers of jitter an d the mean MCD per study in the healthy Chinese adults of 33 μs and 22 μs respectively. Fur thermore, in the MG group, the percentage of jitter > upper normal limit jitter and the impulse blocking percentage were detected, which were all significantly different compared to the normal control group (P < 0.01). The overall sensitivity was 90%, with the abnormality in 6 of t he 9 ocular MG patients and 100% abnormality in the generalized MG patients. The maseter muscle SFEMG has a high degree of sensitivity. The masseter should be considered for SFEMG in the diagnosis of MG, and added routinely to the tested muscles.
and its bacterial flora have been convincingly linked with intestinal disease (

It is now understood that gut bacteria exert effects beyond the local boundaries of the gastrointestinal tract to include distant tissues and overall health. Prototype probiotic bacterium Lactobacillus reuteri has been found to upregulate hormone oxytocin and systemic immune responses to achieve a wide array of health benefits involving wound healing, mental health, metabolism, and myoskeletal maintenance. Together these display that the gut microbiome and host animal interact via immune–endocrine–brain signaling networks. Such findings provide novel therapeutic strategies to stimulate powerful homeostatic pathways and genetic programs, stemming from the coevolution of mammals and their microbiome.
Analysis of Competence Motivation and Employee Character on Public Service Quality Through Human Resources Readiness at the Ministry of Law and Human Rights North Sumatra Regional Office

The provision of public services is one of the most essential government duties since it ensures a nation's progress and promotes wealth and fairness in society. This research is a quantitative research conducted at the Regional Office of the Ministry of Law and Human Rights of North Sumatra Province, this study examines the effect of competence, motivation, and character of employees on Public Service Quality and HR readiness as intervening variables. The number of respondents in this study were 67 people from a total population of 203 people. From the findings, the direct effect shows that: (1) competence and employee character have a positive and significant effect on HR readiness, but the motivational variable has no effect on HR readiness. While the variables of motivation and character of employees have a significant effect on Public Service Quality, while the variables of competence and readiness of human resources have no direct effect on Public Service Quality. (2) Testing the competence, motivation, and character of workers has an indirect effect on Public Service Quality.
Aceruloplasminemia Presents as Type 2 Diabetes Associated with Unexplained Microcytic Anemia: A Case Report

Aceruloplasminemia (ACP) is a rare genetic disorder characterized by the triad of diabetes mellitus, retinal degeneration, and neurological symptoms. The patient’s clinical and biochemical features highlight substantial phenotype heterogeneity, contributing to the difficulties and delay in diagnosing ACP. We described a patient presenting with diabetes and abnormal iron studies due to ACP with typical neuroradiologic abnormality. A 56-year-old female patient visited our hospital with complaints of weight loss and anxiety. The leading cause of unintentional weight loss was uncontrolled diabetes. She was treated with oral hypoglycemic agents. Initial blood tests revealed unexplained microcytic anemia and high ferritin levels. We performed magnetic resonance imaging (MRI) of the brain to alleviate her excessive concerns about normal memory loss. We suspected that she might have ACP, based on the results of cortical pencil lining sign of the brain MRI and microcytic anemia with decreased ceruloplasmin (CP) and increased ferritin levels. Sequence analysis of the CP gene revealed homozygosity for c.2630 G>A, confirming the clinical diagnosis of ACP. The patient was started on deferasirox with progressive normalization of ferritin. In conclusion, unexplained anemia, often with microcytosis, diabetes, and typical neuroradiologic findings, is the best clue for early diagnosis of ACP.
Economic Model Predictive Control of Industrial Demand Response

Large industrial factories can actively participate in the energy market. This does not only provide flexibility for the electrical grids, but also may introduce auxiliary options to their primary business models. However, Demand Response stays usually in contradiction with the production goals. Supplementary revenue contracts with the energy suppliers may help here to balance resulting production losses, thereby revealing a necessity for a trade-off. In this sense, we suggest a concept of demand response utilizing model predictive control for optimal adjustment of the production rate. In particular, in our study we consider the production lines of beverage factories as a use-case.
Characterization and in-vitro cytotoxicity of lupeol isolated from leaf extract of ficus mysorensis

Medicinal plant extracts gain more attention in research of modern medical sciences due to their non-lethal activity. The use of traditional medicine practices from plants has been accepted as a main sources for drug discovery in various health disorder especially cancer. Ficus mysorensis has a long history of usage as traditional medicine. The leaf extract of this plant possess phytochemicals such as alkaloids, flavonoids, terpenoids, steroids, saponins, Phenolics and glycosides. The ethanol leaf extract has been subjected to compound isolation and confirmed by GCMS, HPLC Chromatogram, 13C and 1H nuclear magnetic resonance (NMR), IR spectra. Based on spectral studies the isolated compound confirmed that Lupeol. Lupeol compound was evaluated against MCF-7 cell lines by MTT assay. Lupeol induced an effective change in the cell viability of MCF-7 cells with IC50 concentration (198.75 g/ml). Induction of cell death, change in cell morphology and cancerous cells population was observed in the treated cells, but the normal cells was not affected.
An Enhancement-Mode GaN p-FET With Improved Breakdown Voltage

In this letter, an enhancement-mode (E-mode) GaN p-channel field-effect transistors (p-FETs) with current density of −5.6 mA/mm and <inline-formula> <tex-math notation="LaTeX">${I} _{{\mathrm {ON}}}/{I} _{{\mathrm {OFF}}}$ </tex-math></inline-formula> ratio of 10<sup>6</sup> was demonstrated on a p-GaN/AlN/AlGaN/GaN heterostructure on Si substrate. A decent ohmic contact resistivity of <inline-formula> <tex-math notation="LaTeX">$9.25 \times 10^{-5} \Omega \cdot {\mathrm {cm}}^{2}$ </tex-math></inline-formula> is achieved by capping the heterostructure with a 10-nm heavily Mg-doped p<sup>++</sup>-GaN epilayer. A two-step gate trench etching process, is implemented to overcome the decreased OFF-state blocking voltage associated with the surface p<sup>++</sup>-GaN layer. The proposed structure is compelling for monolithic integration of GaN-based logic and power devices.
Aggressive Stereotactic Radiosurgery Coupled With Immune and Targeted Therapy for Recurrent Melanoma Brain Metastases: A Case Report and Literature Review

Melanoma is a complex disease with a high propensity for brain metastatic spread. Stereotactic radiosurgery (SRS) is a minimally invasive procedure to treat intracranial metastasis with a high rate of local tumor control. In this report, we describe the ongoing management of a patient with interval development of both new and recurrent brain metastases that required seven SRS procedures for a total of 48 brain metastases during a two-year interval while receiving concurrent immunotherapy with ipilimumab and nivolumab. The most recent imaging of the patient showed three brain areas of likely tumor progression despite maintenance nivolumab, and the treatment was recently changed to encorafenib and binimetinib. Combined management with immunotherapy, initial craniotomy, and repeated SRS for new brain metastases resulted in extended survival while preserving neurological function and reducing adverse treatment effects in a patient with advanced metastatic brain melanoma.
Factores asociados a la incapacidad funcional de los ancianos en Brasil: análisis multinivel

OBJETIVO: Analisar a influencia dos fatores demograficos, socioeconomicos, de condicoes de saude e do contexto das unidades da federacao na incapacidade funcional dos idosos. METODOS: Estudo transversal que utilizou dados da Pesquisa Nacional por Amostra de Domicilio (PNAD) de 2003, do Instituto Brasileiro de Geografia e Estatistica (IBGE) e do Instituto de Pesquisa Economica Aplicada (Ipea). A amostra foi constituida de 33.515 individuos com 60 anos ou mais de idade. A variavel dependente foi a incapacidade funcional, mensurada pela dificuldade por subir ladeira ou escada. As variaveis independentes foram divididas em dois niveis: individual (caracteristicas demograficas, socioeconomicas e relativas a saude) e de contexto (Indice de Gini e Produto Interno Bruto per capita por unidade da federacao em 2000). Um modelo de regressao logistica multinomial multinivel foi utilizado para estimar o efeito das variaveis independentes na incapacidade funcional dos idosos. RESULTADOS: A incapacidade funcional foi associada com fatores demograficos, socioeconomicos e de saude. Em nivel individual, o sexo, a educacao, a renda, a ocupacao, a autopercepcao de saude e as doencas cronicas foram os fatores mais fortemente relacionados. Em nivel de contexto, a desigualdade de renda exibiu uma importante influencia. CONCLUSOES: A autopercepcao de saude e o fator mais fortemente relacionado com a incapacidade funcional dos idosos no Brasil, seguida das doencas cronicas. Sexo, ocupacao, escolaridade e renda tambem sao altamente associados. Acoes que abordam os principais fatores associados a incapacidade funcional podem contribuir significativamente para o bem-estar e qualidade de vida dos idosos.
Religious Conversion as a Dialogical Transformation of the Self – The Case of Polish Female Converts to Islam

Abstract Religious conversion affects converts’ beliefs, values, practices, and social worlds. It is a process that entails profound changes in the content and structure of a self and is far from being confined to a single sphere of individual’s functioning. For Polish women who embrace Islam it also involves specific challenges related to becoming a member of a marginalized religious group often perceived by the Polish majority as alien, backward and threatening. Using the Personal Position Repertoire – Focus Group data collection tool and data from in-depth interviews and participant observation we explored the dialogical in-group activity of Polish female converts to Islam. The results of our analysis identified salient features of the converts’ self and situated them in a specific socio-cultural context of the conversion. We argue that the collective voices present in the internal and external dialogues conducted by converts are actively engaged with and appropriated. In this process, converts are able to move between different positions and negotiate their views and practices with the voices representing critical or hostile attitudes with a variety of outcomes, including silencing, rejection, acceptance, and making compromises. We discuss the applicability of the Dialogical Self Theory framework to the research on the dynamic, complex and embodied character of conversion and challenges related to the applied theory and methods.
Parental care interacts with dopamine β-hydroxylase gene in trait of forgiveness with differential susceptibility effect

ABSTRACT Forgiveness, an emotion regulation strategy for overcoming personal distress and healing injuries following interpersonal conflicts, is greatly modulated by parental bonding (e.g. parental care and overprotection) and genetic predispositions. Inspired by the roles of dopamine β-hydroxylase (DBH) gene in empathy and emotion regulation, we examined how parental bonding interacted with the DBH-1021C/T (i.e. a polymorphism accounts for 35–52% of variance in DBH activity) in forgiveness. Results indicated that (1) the score on forgiveness was positively related to parental care, but negatively related to parental overprotection; (2) parental care significantly interacted with the DBH-1021C/T in forgiveness with differential susceptibility model. The TT/CT genotypes were related to lower forgiveness than the CC genotype among individuals with lower parental care, butwere related to higher forgiveness among individuals with optimal parental care. These findings provide a new insight into the gene–environment interaction in the development of forgiveness.
A cc ep te d A rti cl e Prediction of delivery time in the second stage of labor using transperineal ultrasound

cc ep te d A rti cl e Prediction of delivery time in the second stage of labor using transperineal ultrasound Naoto Yonetani1), Ryo Yamamoto1), Masaharu Murata2), Erika Nakajima1), Takako Taguchi1), Keisuke Ishii1), Nobuaki Mitsuda1) 1) Department of Maternal Fetal Medicine, Osaka Medical Center and Research Institute for Maternal and Child Health, Izumi, Osaka, Japan 2) Department of Obstetrics and Gynecology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
EFL Students’ Needs and Achievement: A Study at an Islamic University in Jambi

This study aims to respond the regulation of teaching and learning English in higher education. Since there is no clear regulation of what supposed to be taught, some institutions decide different requirement for the teaching and learning English. This study focused on analyzing and evaluating the students’ actual needs in learning English. A quantitative study was conducted toward 113 non-English department students who have taken English subject in an Islamic University in Jambi. This study explored both of the students’ actual needs and experiences of their learning English in the classroom. The results indicate that having the four skills as a part of teaching and learning English in the classroom is important for the students. The students also mentioned that completing their study is not the only reason to learn English. They believe that learning English is a golden key to be a part of world class community. In spite of mastering reading as the main focus of learning process, the students still face difficulties in understanding the ideas in English since they have limited vocabulary and grammar. They also stated that it is hard for them to get the meaning of what they read because they do not know how the sentences are put together. As the results, it is suggested that the process of teaching and learning English must be revisited
Plastic Waste Mitigation Strategies: A Review of Lessons from Developing Countries

Global plastics waste is an issue of ever-increasing urgency. Estimates suggest some 79% of plastic waste is dumped into the environment, where it is likely to have devastating effects on ecosystems and human health. Marine plastic pollution is a particularly challenging issue, as plastics take decades to break down, and do so into micro- and nanoparticles that affect marine ecosystems and the food web. The plastics pollution problem is magnified in the Global South, where rising production and consumption coexist with underdeveloped waste treatment systems and large volumes of imported plastic waste. This article examines the reasons for the failure to curb plastic waste in Sub-Saharan Africa (SSA) and South Asia (SA), target regions of the Sustainable Manufacturing and Environmental Pollution (SMEP) program funded to address such issues. The article examines the challenges in shifting manufacturing processes and natural materials substitution for reducing plastics waste. It recommends greater external financial and technical support for waste treatment, stakeholder consensus and awareness-building, regulatory policies that reduce the price and convenience differentials between plastics and substitute materials, and a push towards enforcement of environmental regulations.
Improved Data Segmentation Architecture for Early Size Estimation using Machine Learning

Software size estimation plays an important role in project management. According to the report given by Standish Chaos, about 65% of software projects are beyond companies budget or overdue; which could have been saved if an early estimation was imposed. Though the software size can’t be measured directly, but it is related to effort and hence a low effort will lead to low size. The calculation of effort depends upon how the data is organized or segmented. This research paper focuses on the improvement of data segmentation in order to reduce the effort and parallel the size. In order to improve the segmentation architecture, the project data is divided based on the similarity indexes which the projects have in between their attributes. Three similarity measures were used namely Cosine Similarity (CS), Soft Cosine Similarity (SC) and a hybrid similarity index which combines CS and SC. Based on these similarity indexes, the project data is divided into groups by Kmeans algorithm. In order to estimate the size, the co-relation between the formed groups are calculated. To calculate the correlation, Mean Square Error (MSE), Square Error (SE), and Standard Deviation (STD) is calculated and the normalized parameters are used to evaluate the software size. Keywords—Cosine similarity; hybrid similarity; machine learning; size estimation and soft cosine similarity
Gene-gene and gene-environment interactions of the inflammatory gene variants in the development of chronic obstructive pulmonary disease

Chronic obstructive pulmonary disease (COPD) is a complex chronic inflammatory disease that is characterized by partly reversible airflow limitation, chronic inflammation, fibrosis of small airways, and destruction of lung parenchyma. We aimed to assess the association of the inflammatory gene loci singly and in combinations with COPD in smokers and non-smokers in ethnic Tatar from Russia to evaluate the gene-gene and gene-environment interactions in COPD development. Eleven loci of inflammatory genes, including IL19, IL20, IL24, PPBP, IL4, IL4RA, С5, FAS, FASLG, and TGFb1, were genotyped in 484 smoking COPD patients, 517 healthy smokers, 117 non-smoking COPD patients, and 100 healthy non-smokers. Significant associations with COPD in smokers were identified for IL19 (rs2243193), IL4 (rs2243250), IL4 (rs2070874), and PPBP (rs352010). In non-smokers, associations were established for IL24 (rs291107), IL4 (rs2070874), and PPBP (rs352010). Associations of inflammatory genes loci IL19 (rs2243193), IL4 (rs2070874), TGFb1 (rs1800469), PPBP (rs352010), and FASLG (rs763110) and smoking index were determined. Associations of FAS (rs1800682), FASLG (rs763110), IL4 (rs2243250), IL4RA (rs1805010), and PPBP (rs352010) loci with pulmonary function variables were observed. The results of gene-gene interactions analysis showed distinctive patterns of association of inflammatory gene loci with COPD in groups stratified by smoking status. The combination of A allele of IL19 (rs2243193), C allele of IL4 (rs2243250), and T allele of PPBP (rs352010) was the main component of the majority of protective gene-gene combination associated with COPD in smokers. The highest risk of COPD was conferred by TT genotype of PPBP (rs352010) in combination with A allele of FAS (rs1800682). While in non-smokers, the most commonly featured was IL24 (rs291107) C allele in protective patterns and IL24 (rs291107) T allele in predisposing combinations. The highest risk of COPD in non-smokers was detected in a gene-gene combination consisting of A allele of IL12RB2 (rs3762317) together with G allele of IL12A (rs2243115), C allele of IL4 (rs2070874), and A allele of IL4RA (rs1805010).
Synthesis of uniform amplitude sparse linear dipole arrays with multiple shaped‐beam patterns by sharing element rotations and positions

In this article, a novel method of synthesizing sparse linear dipole arrays with multiple shaped‐beam patterns is proposed by finding a set of common element rotations and positions along with individual excitation phases. Compared with most shaped multiple‐pattern synthesis methods using nonuniform amplitude excitations, the proposed method adopts the uniform amplitude excitation and exploits the element rotation as a supplementary degree of array freedom. Such a method enables each amplifier to work at its optimal level and avoids the usage of unequal power dividers for the array feeding network, thus reducing the cost, space, and weight of the radiation system. The shaped multiple‐pattern synthesis problem with multiple constraints including the peak sidelobe level, cross‐polarization level, minimum element spacing, and array length is formulated and optimized by particle swarm optimization. Two examples for synthesizing sparse linear dipole arrays with multiple shaped‐beam patterns are conducted to validate the effectiveness and superiority of the proposed method. Synthesis results show that the proposed method can save antenna elements and avoid the usage of unequal power dividers for test cases. Moreover, the full‐wave simulations are also conducted in these two examples.
[Quality of life in elderly patients living with HIV/AIDS].

This studys objective was to evaluate quality of life in older adults living with HIV/AIDS and the associations with socio-demographic economic and clinical characteristics using a cross-sectional design. Data were collected on demographics disease history and economic status according to the Brazilian Economic Classification Criterion and Targeted Quality of Life Instrument (HAT-QoL). A total of 201 elderly participated with the following characteristics: males (63.7%) single or divorced (51.3%) economic classes C D or E (61.7%) and low schooling (53.7%). Nearly two-thirds (130 or 64.7%) had been infected by the sexual route. The following were significantly correlated with two or up to seven domains in the HAT-QoL: age individual and family income and time since diagnosis. Quality of life in elderly living with HIV/AIDS showed the lowest scores in the domains related to concern over disclosure of their diagnosis sexual activity and financial concerns. Age income and time since diagnosis were the variables that most accounted for altered quality of life.