Miracle-dz/UniFAR-FTUs huggingface dataset:
Significance of lipid profile in antenatal patients for early diagnosis of preeclampsia

Objective: To determine the importance of Lipid Profile in antenatal patients presenting with hypertriglyceridemia for early diagnosis of Preeclampsia at the time of delivery at tertiary care hospital located in Karachi. Methodology: This cross-sectional research was done from 01- April 2013 to 01 October 2013 (6 months), at Department of Obstetrics & Gynecology, JPMC, Karachi. A total of 105 antenatal patients with age limit 18-40 years, single viable pregnancy with gestational age corresponding to>20 to 40thweek. Data was analyzed by SPSS version 16, Mean + SD, frequencies and percentages were calculated. Chi-square test was applied where necessary and P value less than 0.05 considered as significant. Results: The mean age of the subjects was 29.67 ± 5.13 with parity 1.21 ± 0.67 and the gestational period 34.67 ± 3.53 weeks. The mean value of serum Triglyceride was 285 ± 40 mg/dL (201 -372 mg/dL). The frequency of preeclampsia in hypertriglyceridemia subjects was 14.29% (n=15). Eclampsia was identified in (13.33%, n=2), placental abruption occurred in (20%, n=3), HELLP syndrome was observed in (13.33%, n=2) and preterm deliveries happened in (26.67%, n=4) patients. The age of mother, fetal age, parity as well as level of triglycerides in blood serum has influence on incidence of preeclampsia and its outcomes. Conclusion: Our results signify the importance of fasting lipid profile in screening antenatal patients for early diagnosis and prevention of future complications in the mother as well as the child.
Efficacy and safety of sonic hedgehog pathway inhibitors in cancer

The hedgehog pathway, for which sonic hedgehog (Shh) is the most prominent ligand, is highly conserved and is tightly associated with embryonic development in a number of species. This pathway is also tightly associated with development of several types of cancer, including basal cell carcinoma and acute promyelocytic leukemia (APL) among many others. Inactivating mutations in Patched 1 (PTCH1), leading to ligand-independent pathway activation, are frequent in several cancer types but most prominent in basal cell carcinoma. This has led to the development of several compounds targeting this pathway as a cancer therapeutic. These compounds target the inducers of this pathway in Smoothened (SMO) and the GLI transcription factors, although targeting SMO has had the most success. Despite the many attempts at targeting this pathway, there are only three FDA-approved drugs for cancers that affect the Shh pathway. Two of these compounds, vismodegib and sonidegib, target SMO to suppress signaling from either PTCH1 or SMO mutations that lead to upregulation of the pathway. The other approved compound is arsenic trioxide (ATO), which can suppress this pathway at the level of the GLI proteins, although current evidence suggests it also has other targets. This review focuses on the efficacy and safety of these clinically-approved drugs targeting the Shh pathway along with a discussion on other Shh pathway inhibitors being developed.
Electronic Journal of Qualitative Theory of Differential Equations

A positive topological entropy is examined for impulsive differential equations via the associated Poincaré translation operators on compact subsets of Euclidean spaces and, in particular, on tori. We will show the conditions under which the impulsive mapping has the forcing property in the sense that its positive topological entropy implies the same for its composition with the Poincaré translation operator along the trajectories of given systems. It allows us to speak about chaos for impulsive differential equations under consideration. In particular, on tori, there are practically no implicit restrictions for such a forcing property. Moreover, the asymptotic Nielsen number (which is in difference to topological entropy a homotopy invariant) can be used there effectively for the lower estimate of topological entropy. Several illustrative examples are supplied.
Exploring the Potentialities of Particpatory Communication by the Print Media in Agricultural News Reportage in Ghana

The concept of participatory communication gained acceptance as far back as the early 1970s, and now many donor agencies that initially opposed the concept have embraced it as a way of lending moral authority to foreign funded projects [1-7]. Several scholars have written in favour of the power and future of participatory communication and have argued that the fact that most NGOs and other development agencies continue to see the concept as the alternative remedy to overcoming several years of communication challenges is enough reason for its sustenance. They advise that scholars continue to find solutions to some of the challenges that bedevil the participatory approach, such as the time-consuming nature of the concept, the laborious evaluative criteria, and bureaucratic tendencies [8-11]. The overarching belief of many scholars is that the best energising factor for stimulating development and reducing poverty amongst rural communities is to improve access to information, education and knowledge [12]. More importantly, a participatory project attempts to offer a place for participants in some aspects of project implementation and design in order to provide an avenue for engagement with stakeholders. Participation has other advantages for project management. For example, even the most limited community involvement can reduce costs for benefactors, resulting in effectiveness of cost sharing and long-term sustainability of community projects [13,14].
INDUSTRY SECTOR DETERMINANTS OF DIVIDEND POLICY AND ITS EFFECT ON SHARE PRICES IN GHANA

The Study was conducted to examine the industry sector determinants of dividend policy and its effect on share prices of companies listed on the Ghana Stock Exchange for the period 2006-2011. Dividend policy is one of the most debated issues in contemporary corporate finance. In Ghana, very few studies have been done on dividend policy. The Study uses factors such as Price Volatility, Profit After-Tax, Earning Per Share, Size, Growth in Assets, Return on Equity, and Liquidity as explanatory variables and the Dividend Payout as the dependent variable. The study uses a sample of twelve companies (12) covering six different sectors of the economy. In finding out the determinants of dividends policy, panel data regression is performed using the SPSS software. The findings show that the main determinants of dividend policy for companies listed on Ghana Stock Exchange are return on equity, profit after tax and size of the company. There are however, varying factors that influence the dividend payout across the different sectors. Profit After-Tax happens to be a key variable that is International Journal of Economics, Business and Finance Vol. 2, No. 5, August 2014, pp. 1 19, ISSN: 2327 8188 (Online) Available online at http://ijebf.com/ 2 consistently considered by most sectors in paying their dividend. Most of the firms listed on the Ghana Stock Exchange, however show statistically insignificant and weak relation between their Dividend Payout and Share Price. Copyright © IJEBF, all rights reserved.
Criminal profile of migrants’ smuggler across the State Border of Ukraine

The research is grounded on the basic of study of judgments of the national courts of Ukraine against persons who committed human smuggling across the State border of Ukraine. The research covered 360 judgments in the period from 2013 to 2018; the studied judgments were passed against 406 people. The obtained results of the empirical research provides for the primary, reliable and representative information about persons who committed human smuggling across the State border of Ukraine. This made it possible to formulate a criminal profile of migrants’ smuggler. Based on our research, description and analysis, we consider that there is a need for additional researches of the social organization of the illegal transfer of persons across the State border of Ukraine in order to obtain a deeper knowledge of this phenomenon. Especially it concerns the structure of the groups of smuggling of migrants in order to better define the typology of these criminal groups to promote more effective strategies from the side of law enforcement agencies.
Relationship between biochemical indices in hemodialysis patients and mortality; survival analysis

Introduction: People with chronic kidney disease (CKD) undergoing hemodialysis pay high costs and suffer from complications like premature death. Objectives: This study was conducted to determine the relationship of various blood parameters in hemodialysis with premature death. Patients and Methods: In this cross-sectional study, 90 hemodialysis patients were enrolled using consensus sampling method. Demographic characteristics were recorded. Additionally, serum level of ferritin and biochemical parameters were assessed. The log-rank test for survival probability and Cox proportional-hazards model were applied to examine the correlation between assessed factors and the risk of premature death. Results: The results of log-rank test showed that only coronary artery disease (CAD) and serum ferritin have a role in predicting survival probability, since the survival rate of the people with and without CAD was about 25 months (with a confidence interval of 37.60 - 12.36) and 46 months (with a confidence interval of 51.63-40.36) (P = 0.041) respectively. Conclusion: It seems that both serum ferritin levels and cardiovascular diseases are effective factors to predict premature death in hemodialysis patients.
Bioisosteric modification on melatonin: synthesis of new naphthalene derivatives, in vitro antioxidant activity and cytotoxicity studies

Melatonin (MLT) is a strong free radical scavenger that protects the body from the deleterious effects of excess oxidants. Synthesis of MLT analogue compounds with antioxidant potency has recently attracted the interest of researchers. In general, the strategy consists of modifying the groups in the different sites of the indole ring or replacing the indole ring with an analogue. As part of our ongoing research, the antioxidant capacity and cytotoxicity of newly synthesized MLT analogue naphthalene derivatives were evaluated. The radical scavenging activity was tested by a 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay. Most of the synthesized compounds showed significant antioxidant activity in comparison to MLT. The structure-activity relationship was identified. The in vitro cytotoxic effects of the synthesized compounds were also investigated in CHO-K1 cells using the MTT assay.
Zebrafish an emerging model for Preclinical Drug Discovery

For understanding the pathogenesis of human disease at cellular and molecular level bio medical research depends on the use of animal models. Maximum animal models used in medical research of human disease are basically performed in murine system. Though there are advantages of using these animals, murine’s have long gestational period, sexual maturation rate and are expensive. These invertebrates lack many structures and organ systems that are involved in human disease pathogenesis. Forward-genetic screens and random mutagenesis based reverse genetics though possible in mouse and are currently underway; they cannot be done on a large scale as they require considerable staff and infrastructure support. Due to these drawbacks other animal models have been developed that provide initial genetic or drug target information. For developmental genetic studies larval zebra ish are used extensively due to their small size, external development, optical transparency, and accessibility in large numbers. Not only are they vertebrate, they also have high fecundity, which can be easily visualised and experimentally manipulated. 70% of all human disease genes have functional homologous in zebra ish. There has been signi icant increase in the use of zebra ish to elucidate the etiology of human disease like cancer, infectious diseases, cardiovascular disease, kidney disease, diabetes, blindness, deafness, digestive diseases, hematopoiesis, muscle disorders and neural disorders.
BIOACCUMULATION OF POLLUTANTS FROM TEXTILE WASTE WATER BY HYDROCOTYLE UMBELLATA L

Textile industry has posed serious environmental problems causing adverse health effects, thus making it a social obligation for industries to minimize water pollution. During the present study, sample was collected from textile industry of Faisalabad and their analysis showed that the discharge of textile waste water was violating PEPA, (1997) as most of their results was found above their permissible limits of NEQS (1997) including pH, EC,TDS, BOD, COD, SO4 , Cu and Cr. Among the treatment technologies, Phytoremediation is feasible and environmental friendly method for the removal of pollutants from the industrial effluents. A study was carried out to investigate the phytoremediation of pollutants from textile wastewater by Hydrocotyle umbellata L. Reduction in the pollutants load was achieved from 11.37 to 7.03 (pH), 2138 to 1202 (TDS), 18.02 to 15.87 (EC), 900 to 500 (Cl), 4833.3 to 2535.1 (SO4 ), 3.26 to 2.01 (NO3 ), 7000 to 2500 to (CO3 ), 7500 to 4030 (HCO3 ), 533 to192 (COD), 246.45 to 86.5 (BOD), 0.138 to 0.13 (Cu), 1.012 to 0.13 (Cr), 0.46 to 0.026 (Zn) by Hydrocotyle umbellata . Phytoremediation using aquatic plants provide a potential opportunity to remove contaminants from the waste water. Aquatic plant Hydrocotyle umbellata accumulated the contaminants when introduced in textile waste water. Hydrocotyle umbellata has the potential to be used in phytoremediation to remove metal pollutants from contaminated textile wastewaters.
NDT_A_226296 681..690

Srihari Gopal 1 Jagadish Gogate Katalin Pungor 2 Edward Kim 3 Arun Singh 1 Maju Mathews 1Janssen Research and Development, LLC, Titusville, NJ, USA; 2Medical Affairs, EMEA, Janssen-Cilag, Neuss, Germany; 3Janssen Scientific Affairs, Janssen Pharmaceuticals, Titusville, NJ, USA Background: Negative symptoms in schizophrenia are associated with impairments in social and cognitive functioning leading to substantial long-term disability. Available antipsychotic treatments have demonstrated only modest benefit in the improvement of negative symptoms. Objective: To compare improvements in negative symptoms among patients treated with paliperidone palmitate 3-month (PP3M) or paliperidone palmitate 1-month (PP1M) long-acting injectable (LAI) formulations. Methods: Data from a randomized double-blind (DB), phase-3, non-inferiority study in patients with schizophrenia were analyzed. Following screening, patients entered a 17-week open-label (OL) phase to receive flexibly dosed PP1M followed by a 48-week DB phase where patients were randomized (1:1) to receive either PP1M or PP3M. Positive and Negative Syndrome Scale (PANSS) total scores with emphasis on 7-item negative subscale scores for PP1M vs PP3M were assessed. Results: Of 1429 patients enrolled, 1016 were randomized to receive PP3M (n=504) or PP1M (n=512). At baseline, mean (SD) PANSS negative subscale was 23.2 (4.60) and negative symptom factor score was 22.3 (4.87), indicating moderate-to-severe negative symptoms. Negative subscale and symptoms factor scores showed continuous improvements throughout OL (15.9 [4.99]) and DB (14.9 [4.81]) phases. Mean (SD) changes from DB baseline in the PANSS negative subscale score were comparable between PP1M (–1.4 [3.67]) and PP3M (–1.4 [3.63]) treatment groups. Conclusion: Treatment with PP3M or PP1M demonstrated comparable improvement in negative symptoms in patients with moderate-to-severe negative symptoms and in patients with prominent negative symptoms. Long-term treatment with PP3M demonstrated benefit, suggesting that continuous antipsychotic medication treatment for >1 year is needed to achieve greater benefit for negative symptoms. Trial Registration: ClinicalTrials.gov Identifier: NCT01515423.
SIK1 silencing associated with proliferation indicates negative prognosis in patients with hepatocellular carcinoma

Background: An evolutionarily conserved gene, the Salt-inducible kinase 1 (SIK1), functions to control mammalian life span and regulates human cells proliferation. However, the role of SIK1 in hepatocellular carcinoma (HCC) remains unclear. This study was aimed at investigating the expression pattern and clinicopathological significance of SIK1 in patients with HCC. Methods: The mRNA and protein expression levels of SIK1 were analyzed in eight HCC lines and eight paired HCC tumors by real-time PCR, Western blotting and immunohistochemical staining. Statistical analysis was used to evaluate the clinicopathological significance of SIK1 expression. Short hairpin RNA interfering approach was employed to suppress endogenous SIK1 expression in HCC cells to determine its role in proliferation. Results: SIK1 expression in liver cancer cell lines and tissues was significantly silenced at both the mRNA and protein levels compared with that in normal cells and adjacent non-tumorous liver tissues (ANT). SIK1 expression was strongly associated with HBsAg, AFP, tumor size, number of tumors, tumor encapsulation, vascular invasion, one year recurrence and five year recurrence. HCC patients with low SIK1 expression displayed a shorter overall survival and a higher recurrence rate than those with high SIK1 expression (P<0.05, respectively). Additionally, stable high-expression of SIK1 in HCC cells suppressed cell proliferation in vitro. Similarly, an in vivo assay showed that SIK1 up-regulation in hepatocellular carcinoma cells inhibited remarkably tumor proliferation potential in tumor size and weight. Conclusions: SIK1 protein may serve as a candidate prognostic marker and a novel therapeutic target for HCC and play an important role in inhibit proliferation and enhanced progression of HCC.
HEM2019000055C 505..512

In countries with access to organized health care, survival of children with sickle cell disease (SCD) has greatly improved, resulting in a growing population of adults with SCD. Transition from pediatric to adult care presents many challenges for the patient, who now faces the reality of emerging complications in many organs that are cumulative, adding to other age-related nonsickle conditions that interact and add to the disease morbidity. We recommend regular comprehensive annual assessments, monitoring for early signs of organ damage and joint clinics with relevant specialists, if applicable. While maintaining a low threshold for intervention with disease-modifying therapies, we should always keep in mind that there is no single complication that is pathognomonic of SCD, and nonsickle comorbidities should always be excluded and treated if present. We need to reevaluate our approach to managing adults with SCD by putting a greater emphasis on multidisciplinary care while proactively considering curative options (hematopoietic stem cell transplant and gene therapy) and experimental pharmacological agents for adults with SCD of all ages before complications render the patients ineligible for these treatments.
Phosphate sorption indices as affected by the calcareousness of soils

An experiment was carried out to study the effects of calcareousness on phosphate sorption indices of soils using three representative calcareous soils, namely Sara (Aquic Eutrochrept), Gopalpur (Aquic Eutrochrept), and Ishurdi (Aeric Haplaquept) series of Bangladesh. Three non-calcareous soils, namely Belabo (Typic dystrudepts), Sonatala (Aeric Endoaquepts) and Ghatail (Aeric Haplaquept) series were also selected for comparison purposes. Phosphate sorption indices of soils were calculated using Langmuir and Freundlich isotherms. Isotherms were constructed taking one gram of air-dried sieved (< 2 mm) soil into a 50 ml centrifuge tube, and subsequently adding seven initial P concentrations, namely 0, 1, 10, 25, 50, 100 and 150 μg/ml to each centrifuge tube employing a soil/solution ratio of 1 : 20 (w/v). According to the Langmuir equation, the amount of phosphate sorbed followed the order: Sonatala > Ghatail > Sara = Gopalpur > Ishurdi > Belabo. The abundance of amorphous iron rather than the calcareousness was putatively responsible for the high phosphate sorption capacity of soils. Maximum phosphorus buffering capacity (MPBC) of the calcareous soils ranged from 33.4 - 62.8 l/kg. Langmuir and Freundlich equations produced different values for soil P requirements (SPR) at 0.2 and 1.0 mg P/l. Calcareous soils would require 27 - 44 mg P/kg soil to attain 0.2 mg P/l soil solution, which is deemed sufficient for crop growth. The soils would require 32 - 58 mg P/kg soil to reach 1.0 mg P/l soil solution, which is regarded to be safe for soils in terms of susceptibility to P losses. The calculated Langmuir constant b values were higher than the threshold value of 0.07 l/mg for two of the calcareous soils. Therefore, even though the non-calcareous soils sorbed more phosphate, higher bonding energy of P sorption for calcareous soils makes them less vulnerable to loss via surface runoff. Dhaka Univ. J. Biol. Sci. 28(1): 93-110, 2019 (January)
Shift from Hippocampal to Neocortical Centered Retrieval Network with Consolidation

The standard model of system-level consolidation posits that the hippocampus is part of a retrieval network for recent memories. According to this theory, the memories are gradually transferred to neocortical circuits with consolidation, where the connections within this circuit grow stronger and reorganized so that redundant and/or contextual details may be lost. Thus, remote memories are based on neocortical networks and can be retrieved independently of the hippocampus. To test this model, we measured regional brain activity and connectivity during retrieval with functional magnetic resonance imaging. Subjects were trained on two sets of face–location association and were tested with two different delays, 15 min and 24 h including a whole night of sleep. We hypothesized that memory traces of the locations associated with specific faces will be linked through the hippocampus for the retrieval of recently learned association, but with consolidation, the activity and the functional connectivity between the neocortical areas will increase. We show that posterior hippocampal activity related to high-confidence retrieval decreased and neocortical activity increased with consolidation. Moreover, the connectivity between the hippocampus and the neocortical regions decreased and in turn, cortico-cortical connectivity between the representational areas increased. The results provide mechanistic support for a two-level process of the declarative memory system, involving initial representation of new associations in a network including the hippocampus and subsequent consolidation into a predominantly neocortical network.