Miracle-dz/UniFAR-FTUs huggingface dataset:
Sources of metallogenic materials and metallogenic mechanism of Daliangzi Ore Field in Sichuan Province: Constraints from geochemistry of S,C,H,O,Sr isotope and trace element in sphalerite

The Daliangzi Pb-Zn deposit located on the southwestern margin of the Yangtze Craton,with reserve of 1. 80Mt and averaging grade of 11. 45%( lead + zinc),is one of the famous high-grade Pb-Zn ore fields in the Sichuan-Yunnan-Guizhou metallogenic belt. Geochemistry of Sr,C,H,O,S isotope and trace element in sphalerite is discussed in this paper in an effort to understand the sources of the ore metals and ore-fluids which cause many different opinions in understanding the genesis of the deposit. The results show that the Ge / In and Ga / In of sphalerites with As,Sb and Ag enriched are much bigger than 100 which indicate the metallogenic environment is of mid-low temperature. The origin of a mix of meteoric and metamorphic( formation) water can be inferred after the datum that the δ18O H2O values range from- 6. 02‰ ～ 3. 31‰ and the δD values range from- 74. 6‰ ～- 40. 3‰ of the orefluids. δ13C V-PDB and δ18O V-SMOW values of the hydrothermal gangue minerals calcite and dolomite are- 3. 5‰ ～ + 1. 4‰ and + 11. 6 ～ + 18. 1‰,indicating that the CO 2 in the ore-forming fluid was derived from the dissolution of Sinian carbonates and was greatly affected by the meteoric water and organic carbon in the ore bearing rock. The most of δ34S values of sulfides are 10‰ ～ 20‰,and the δ34S values of sulfates are 20. 2‰ ～ 38. 7‰,suggesting that the sulfur should be derived from the in-situ thermochemical reduction of sulfates from the sedimentary strata. The initial87Sr /86Sr values of the ore-forming fluid are 0. 707137 ～ 0. 714588 with the mean value of 0. 711951 which are higher than87Sr /86Sr values( 0. 70834 ～ 0. 70861) of the host rock Sinian dolomite and lower than87Sr /86Sr values( 0. 7249 ～ 0. 7288) of the basement and some part of the Sinian formation which had high87Sr /86Sr values,implying that the ore-forming fluid probably migrated through the basement and the Sinian formation and experienced water-rock reaction and isotope exchange among the ore fluid,the basement and Sinian formation.
The Impact of Hydrogen Peroxide (H2O2) Fumigation on Bacterial Levels in Dental Office Environments: A Randomized Clinical Trial Investigation

Background: Fumigation with hydrogen peroxide has proven to be a highly effective approach to maintaining biological safety within dental offices. The main purpose of this research was to investigate the efficacy of hydrogen peroxide (H2O2) fumigation in reducing bacterial levels in dental office environments. Methods: The study involved 30 participants diagnosed with moderate caries decay (ICDAS 3 and 4) in their mandibular molars. Sixty Petri dishes (two per patient) with Columbia Agar and 5% Sheep Blood were opened at the beginning of the caries treatment. After the completion of caries treatment and tooth restoration, 30 plates (G1 group) were closed. Following this, a 20 min fumigation procedure with 6% hydrogen peroxide biosanitizer using a compressed air device was conducted. After the fumigation, the remaining plates were closed (G2 group). The total number of bacteria CFUs (colony-forming units) in the dental office air was determined using the Koch sedimentation method. Results: The total bacterial colony (TBC) level, measured in cfu/m3, demonstrated a significant decrease in the number of bacteria following room environment fumigation (163.1 ± 145.7; G2 group) compared to non-fumigated samples (817.2 ± 208.2; G1 group) (p < 0.001). The predominant bacteria observed in the microbiological plates before fumigation were Micrococcus and Bacillus species, found in 80% (24/30) and 60% (18/30) of the plates, respectively. Application of H2O2 room fumigation resulted in a significant reduction in bacterial numbers: 79.2% (5/30) for Micrococcus species (p < 0.001), 83.3% (3/30) for Bacillus species (p < 0.001), and 100% (0/30) for Staphylococcus arlettae (p < 0.05). Conclusion: Fumigation with 6% H2O2 is an effective method for reducing bacterial counts in a dental office environment.
Nicotinamide-Expanded Allogeneic Natural Killer Cells with CD38 Deletion, Expressing an Enhanced CD38 Chimeric Antigen Receptor, Target Multiple Myeloma Cells

Natural killer (NK) cells are a vital component of cancer immune surveillance. They provide a rapid and potent immune response, including direct cytotoxicity and mobilization of the immune system, without the need for antigen processing and presentation. NK cells may also be better tolerated than T cell therapy approaches and are susceptible to various gene manipulations. Therefore, NK cells have become the focus of extensive translational research. Gamida Cell’s nicotinamide (NAM) platform for cultured NK cells provides an opportunity to enhance the therapeutic potential of NK cells. CD38 is an ectoenzyme ubiquitously expressed on the surface of various hematologic cells, including multiple myeloma (MM). It has been selected as a lead target for numerous monoclonal therapeutic antibodies against MM. Monoclonal antibodies target CD38, resulting in the lysis of MM plasma cells through various antibody-mediated mechanisms such as antibody-dependent cellular cytotoxicity (ADCC), complement-dependent cytotoxicity, and antibody-dependent cellular phagocytosis, significantly improving the outcomes of patients with relapsed or refractory MM. However, this therapeutic strategy has inherent limitations, such as the anti-CD38-induced depletion of CD38-expressing NK cells, thus hindering ADCC. We have developed genetically engineered NK cells tailored to treat MM, in which CD38 was knocked-out using CRISPR-Cas9 technology and an enhanced chimeric antigen receptor (CAR) targeting CD38 was introduced using mRNA electroporation. This combined genetic approach allows for an improved cytotoxic activity directed against CD38-expressing MM cells without self-inflicted NK-cell-mediated fratricide. Preliminary results show near-complete abolition of fratricide with a 24-fold reduction in self-lysis from 19% in mock-transfected and untreated NK cells to 0.8% of self-lysis in CD38 knock-out CAR NK cells. Furthermore, we have observed significant enhancements in CD38-mediated activity in vitro, resulting in increased lysis of MM target cell lines. CD38 knock-out CAR NK cells also demonstrated significantly higher levels of NK activation markers in co-cultures with both untreated and αCD38-treated MM cell lines. These NAM-cultured NK cells with the combined genetic approach of CD38 knockout and addition of CD38 CAR represent a promising immunotherapeutic tool to target MM.
Le Givetien en Avesnois (Nord de la France) : paléoenvironnements et implications paléogéographiques

La coupe de Glageon est situee a l'ouest des affleurements classiques du Givetien du bord sud du Synclinorium de Dinant. Cette localisation et la qualite de l'affleurement nous ont conduits a effectuer un leve detaille, suivi d'une etude sedimentologique et paleontologique (coraux). Seize microfacies carbonates, etages depuis un milieu marin ouvert, relativement profond jusqu'a un milieu proche de l'emersion ont ete mis en evidence. Une breve etude de l'evolution des paleoenvironnements montre que si les Formations des Terres d'Haurs, du Mont d'Haurs et de Fromelennes sont relativement semblables a leurs equivalents de la region de Givet, la Formation de Trois-Fontaines est partiellement differente. Cette divergence se resume surtout a l'absence de complexe lagunaire au dessus du premier biostrome des auteurs. L'interpretation sequentielle montre l'imbrication de trois ordres de variations paleobathymetriques controlant les mecanismes de la sedimentation. Une sequence diagenetique a ete mise en evidence. La diagenese d'enfouissement y predomine nettement, apres une breve phase de cimentation meteorique distale.
Is climate sensitivity related to dynamical sensitivity?

The atmospheric response to increasing CO2 concentrations is often described in terms of the equilibrium climate sensitivity (ECS). Yet the response to CO2 forcing in global climate models is not limited to an increase in global‐mean surface temperature: for example, the midlatitude jets shift poleward, the Hadley circulation expands, and the subtropical dry zones are altered. These changes, which are referred to here as “dynamical sensitivity,” may be more important in practice than the global‐mean surface temperature. This study examines to what degree the intermodel spread in the dynamical sensitivity of 23 Coupled Model Intercomparison Project phase 5 (CMIP5) models is captured by ECS. In the Southern Hemisphere, intermodel differences in the value of ECS explain ~60% of the intermodel variance in the annual‐mean Hadley cell expansion but just ~20% of the variance in the annual‐mean midlatitude jet response. In the Northern Hemisphere, models with larger values of ECS significantly expand the Hadley circulation more during winter months but contract the Hadley circulation more during summer months. Intermodel differences in ECS provide little significant information about the behavior of the Northern Hemisphere subtropical dry zones or midlatitude jets. The components of dynamical sensitivity correlated with ECS appear to be driven largely by increasing sea surface temperatures, whereas the components of dynamical sensitivity independent of ECS are related in part to changes in surface temperature gradients. These results suggest that efforts to narrow the spread in dynamical sensitivity across global climate models must also consider factors that are independent of global‐mean surface temperature.
The Role of Brand Trust in Mediating the Effect of Social Media Marketing on Brand Loyalty at Falala Chocolate Customers in Denpasar

Consumption of chocolate in Indonesia continues to increase every year, this can be an opportunity for businessmen to open a business with the main product of chocolate. Falala Chocolate Bali takes advantage of this opportunity by selling and marketing unique and attractive artisan chocolate products. This study aims to analyze the role of brand trust in mediating the effect of social media marketing on brand loyalty. This study was conducted at Falala Chocolate in Denpasar City, with a sample of 100 people who were determined by purposive sampling. Data was collected using a survey approach, and the study instrument was a questionnaire measured by a Likert scale. The data were analyzed using path analysis. The results of this study indicate that all hypotheses are accepted. Social media marketing has a positive and significant effect on brand loyalty, social media marketing has a positive and significant effect on brand trust, brand trust has a positive and significant effect on brand loyalty, and brand trust has a significant role in mediating the influence of social media marketing on brand loyalty.
Short-Term Power Load Forecasting Based on ICEEMDAN-GRA-SVDE-BiGRU and Error Correction Model

The significance of short-term power load forecasting extends to grid dispatching and future planning. To address the issues of nonlinear characteristics and poor prediction accuracy of original power load, a hybrid short-term power load forecasting method was proposed based on Improved Complete Ensemble Empirical Mode Decomposition with Adaptive Noise (ICEEMDAN), Grey Relation Analysis (GRA), Improved Secondary Variation Differential Evolution Algorithm (SVDE), Bidirectional Gated Recurrent Unit (BiGRU) and Error Correction Model. Firstly, ICEEMDAN decomposition is used to divide the sequence into Intrinsic Mode Functions (IMF) and a residual component (Res), and GRA is used to reconstruct the partial component sequences to improve the model operation efficiency and anti-interference ability. Then, an Improved Secondary Variation Differential Evolution Algorithm (SVDE) is proposed to perform hyperparameter optimization on BiGRU neural networks to predict the processed component sequences. Finally, an Error Correction Model based on SVDE-BiGRU is established by the processed mode components and factors such as temperature and holiday weekends to further increase the accuracy of its load prediction. The experimental results show that the RMSE, MSE, and MAPE of the prediction method are 89.72, 60.56, and 0.55% on average, respectively. Compared with the common BiGRU prediction method its MAE value is reduced by 79.02%. Compared with several mainstream methods, its MAE value is reduced by 70.88% at maximum and 40.62% at minimum, which proves the effectiveness and accuracy of the proposed method in short-term power load forecasting.
Resonant DC link soft-switching inverter with low-loss auxiliary circuit

ABSTRACT An auxiliary switching device is usually set on the DC bus of the resonant DC link inverter, which restricts the efficiency of the inverter and is also one of the reasons for its not extensive application and promotion in the high-power field. To solve the problem, auxiliary circuits and DC bus of the resonant DC link soft-switching inverter designed in this paper are connected in parallel, and auxiliary switching devices and resonant elements are not connected in series on the DC bus, which help to improve the efficiency and reduce the power losses of the auxiliary resonant circuits. Based on the equivalent circuits in different operating modes, the paper analyzes the working process of the soft-switching inverter, soft-switching realization conditions and design rules. A 10 kW laboratory prototype is built, and through the comparison of the experimental results from it and the hard-switching inverter, it is shown that the efficiency improvement value of the designed inverter at full load is higher than that at light load. Therefore, the soft-switching inverter designed in this paper is conductive to reducing the power losses of the auxiliary resonant circuits and ensuring the efficient use of the electric energy.
Comprehending Turkish sentences using word order, thematic roles, and case

A core aspect of sentence comprehension is assigning thematic roles such as agents and patients to nouns. Turkish, a flexible word order language with accusative case-marking, allows us to compare the relative effect of word order, case-marking, and thematic reversibility in sentence comprehension. We conducted two spoken language comprehension experiments to investigate the relationships among these factors. Native Turkish-speaking adults were faster and more accurate in comprehending sentences with default word order than those with scrambled word order; case-marked sentences than non-casemarked sentences; and sentences with thematically irreversible nouns than those with reversible nouns. The effect of word order depended on the reversibility of the nouns, and case-marking had little-to-no effect on comprehension when the nouns were thematically irreversible. Our results suggest that while Turkish speakers use multiple cues to map thematic roles onto nouns, there are diminishing returns of facilitation with each additional source of information. These results give support to race-based models of sentence comprehension.
Evaluation of Two Recombinant Protein-Based Vaccine Regimens against Campylobacter jejuni: Impact on Protection, Humoral Immune Responses and Gut Microbiota in Broilers

Simple Summary Campylobacter is the most common cause of human bacterial gastroenteritis, and poultry products are the main source of exposure. To reduce human campylobacteriosis, it is necessary to reduce the contamination level of Campylobacter in live poultry. Vaccination could be a solution, but no vaccines for Campylobacter are available to date. In our previous study, a vaccine candidate induced partial protection against Campylobacter in broilers. The objective of the present study was to evaluate whether a protein-based vaccine inoculated at two different frequencies (two or four times) would help to improve the protective immune response during a 42-day trial in broilers orally infected by the bacterium. A specific antibody response was observed regardless of the frequency of inoculation. Moreover, microbiota analysis revealed that significant differences were observed between the groups, but that vaccination did not alter the relative abundance of the main bacterial taxa residing in the caeca. No reduction in Campylobacter caecal load was observed regardless of the vaccine regimen tested. Additional studies testing other vaccine candidates are needed to develop an effective vaccine against Campylobacter in broilers. Abstract Campylobacter infections in humans are traced mainly to poultry products. While vaccinating poultry against Campylobacter could reduce the incidence of human infections, no vaccine is yet available on the market. In our previous study using a plasmid DNA prime/recombinant protein boost vaccine regimen, vaccine candidate YP437 induced partial protective immune responses against Campylobacter in broilers. In order to optimise vaccine efficacy, the vaccination protocol was modified using a protein prime/protein boost regimen with a different number of boosters. Broilers were given two or four intramuscular protein vaccinations (with the YP437 vaccine antigen) before an oral challenge by C. jejuni during a 42-day trial. The caecal Campylobacter load, specific systemic and mucosal antibody levels and caecal microbiota in the vaccinated groups were compared with their respective placebo groups and a challenge group (Campylobacter infection only). Specific humoral immune responses were induced, but no reduction in Campylobacter caecal load was observed in any of the groups (p > 0.05). Microbiota beta diversity analysis revealed that the bacterial composition of the groups was significantly different (p ≤ 0.001), but that vaccination did not alter the relative abundance of the main bacterial taxa residing in the caeca. The candidate vaccine was ineffective in inducing a humoral immune response and therefore did not provide protection against Campylobacter spp. infection in broilers. More studies are required to find new candidates.
Does denosumab exert a protective effect against COVID-19? Results of a large cohort study

Introduction Denosumab is a monoclonal antibody blocking the receptor activator of nuclear factor kappa-B/receptor activator of nuclear factor kappa-B ligand (RANK/RANKL) pathway, thus inhibiting osteoclastogenesis. Since RANK and RANKL are also involved in the immune system activation, denosumab might interfere with the response against infections. Our study aimed to explore the relationship between denosumab treatment and coronavirus disease 2019 (COVID-19). Design and methods The occurrence and severity of COVID-19 were recorded in consecutive patients referred to the Endocrinology Department of Papa Giovanni XXIII Hospital, Bergamo, from 1 January 2020 to 1 January 2021. Patients treated with denosumab were compared to outpatient controls. Patients’ features were summarized by descriptive statistics. Multivariate logistic regression assessed the relationship between denosumab and COVID-19, adjusting for potential confounders. Subgroup analyses according to age, sex, body mass index (BMI), smoking status, and vitamin D levels were performed. Results The final population included 331 patients treated with denosumab and 357 controls. COVID-19 incidence was lower in the denosumab group (7.6% vs. 14.6%, p = 0.004). COVID-19 severity was similar in both groups. Multiple logistic regression confirmed an association between denosumab and a reduced occurrence of symptomatic COVID-19 [odds ratio (OR) 0.46, 95% CI 0.21–0.98, p = 0.049]. Subgroup analyses suggested a potential protective effect of denosumab in patients over 75 years (OR 0.12, 95% CI 0.02–0.6, p = 0.011), with a significant interaction between denosumab and age categories (p = 0.047). Conclusion Our study confirms that denosumab may be safely continued in COVID-19 patients. RANK/RANKL inhibition seems associated with a reduced incidence of symptomatic COVID-19, particularly among the elderly.
Interdisciplinary Multidimensional Assessment of Transthyretin Amyloidosis before and after Tafamidis

Background: Clinically, there is considerable heterogeneity in the presentation of transthyretin amyloidosis (ATTR), which ranges from primarily cardiac and primarily neurologic to mixed disease, among other manifestations. Because of this complex presentation, the diagnosis and management of patients with ATTR are often challenging and should be performed in interdisciplinary centers specialized in amyloidosis. Here, we aimed to increase awareness of ATTR detection and pathophysiology through a multidimensional multiorgan approach. Case report: We reported on a 60-year-old man with wild-type ATTR who underwent a number of both basic and advanced cardiological and neurological investigations at baseline and after a treatment period with the TTR tetramer stabilizer, tafamidis. Several findings are provided here, some of which might be considered instrumental correlates of the patient’s clinical improvement after therapy. Conclusions: Adequate awareness and prompt recognition of ATTR support early diagnosis and faster access to therapies, thereby slowing the progression and improving the prognosis. The need for a multidisciplinary alliance between specialists and the opportunity to perform, at least in selected cases, a set of specific examinations for a detailed assessment of ATTR patients can also provide valuable insights into the physiopathology and response to therapy of a disease as complex and intriguing as ATTR.
Fraud in Tax Evasion Decision: Effect on Financial Pressure, Tax Investigation and the Perceived Probability of Audit

Purpose – This research aims to investigate the effects of financial pressure, the perceived probability of audit, and tax investigation on the decision to carry out tax evasion. Design/methodology/approach – The Study is a quantitative research approach that uses online-based data collection methods (e_ questionnaire) combined with interviews with certain taxpayers to get their views on fraud in tax evasion decisions. The sample in this study was 98 individual taxpayers in Indonesia. Findings – This research shows that financial pressures have a dominant effect on tax avoidance. This finding proves that financial pressure is one of the reasons for committing tax evasion fraud as stated in the fraud triangle theory. This research also shows that the perceived probability of audit and tax investigation does not affect reducing the tendency to tax evasion, this research indicates that tax investigation does not have a deterrent effect on taxpayers in committing tax evasion. Taxpayers understand that the government is spending considerable time and money to prove an alleged tax evasion case. Several tax policies in Indonesia such as the sunset policy, tax amnesty, and voluntary tax reporting can provide space for tax evaders to get certain tax collections and tax deductions when making tax payments. Research limitations/implications – Although this research has explored taxpayers in Indonesia with several different occupational backgrounds, it is still necessary to test tax evasion on corporate taxpayers other than personal taxpayers. Practical implications – This research critically analyzes the impact of psychological factors in tax non-compliance decisions through tax evasion fraud. Social implications – The behavioral approach and consideration of psychological factors in every tax decision are expected to help realign and harmonize law enforcement practices in Indonesia to reduce the occurrence of tax evasion in Indonesia. Originality/value – Examines the implementation of fraud triangle theory in tax evasion decisions. This research combines behavioral and psychological approaches to test the occurrence of tax evasion fraud in the perspective of taxpayers in Indonesia.