Miracle-dz/UniFAR-FTUs huggingface dataset:
Health promotion in early-stage dementia – user experiences from an educative intervention

ABSTRACT Educating and supporting people with early-stage dementia has gained increased focus worldwide as a response to an aging population and limited advancements in the medical treatment of the condition. The aim of this study was to explore the experiences of people with early-stage dementia who were provided with support and information through a 12-week health promotion course and identify elements of the intervention potentially contributing to coping and adjustment to the condition. Data was collected through individual semi-structured interviews with 32 people with dementia after they had attended the course. For each participant, a care partner was also interviewed. The data were analyzed using systematic text condensation. Three main categories emerged from the analysis. These were: (I) bridging the post-diagnostic information gap, (II) facilitating health behavior changes, and (III) new perspectives on living with the condition. The results demonstrated that the intervention was well-received by the participants. Learning about dementia, meeting others in the same situation, and focusing on maintaining a healthy lifestyle was particularly highlighted, as was promoting family communication.
HLA-G and Other Immune Checkpoint Molecules as Targets for Novel Combined Immunotherapies

HLA-G is an HLA-class Ib molecule that is involved in the establishment of tolerance at the maternal/fetal interface during pregnancy. The expression of HLA-G is highly restricted in adults, but the de novo expression of this molecule may be observed in different hematological and solid tumors and is related to cancer progression. Indeed, tumor cells expressing high levels of HLA-G are able to suppress anti-tumor responses, thus escaping from the control of the immune system. HLA-G has been proposed as an immune checkpoint (IC) molecule due to its crucial role in tumor progression, immune escape, and metastatic spread. We here review data available in the literature in which the interaction between HLA-G and other IC molecules is reported, in particular PD-1, CTLA-4, and TIM-3, but also IDO and TIGIT. Clinical trials using monoclonal antibodies against HLA-G and other IC are currently ongoing with cancer patients where antibodies and inhibitors of PD-1 and CTLA-4 showed encouraging results. With this background, we may envisage that combined therapies using antibodies targeting HLA-G and another IC may be successful for clinical purposes. Indeed, such immunotherapeutic protocols may achieve a better rescue of effective anti-tumor immune response, thus improving the clinical outcome of patients.
Antibacterial Effect of Silver Nanoparticles Is Stronger If the Production Host and the Targeted Pathogen Are Closely Related

Microbial resistance to antibiotics is one of the key challenges that lead to the search for alternate antimicrobial treatment approaches. Silver nanoparticles (AgNPs) are well known for their antimicrobial effects against a wide variety of drug-resistant microorganisms. AgNPs can be synthesized using microbial hosts, using a green and economical synthesis route, which produces extremely stable and highly active nanoparticles. Such green AgNPs are coated with a biological coating often referred to as a corona, originating from the production microorganism. In this study, we asked whether the composition of the biological corona might influence the antimicrobial activity of green AgNPs. To investigate this, we produced AgNPs in Pseudomonas putida KT2440 and Escherichia coli K12 MG1655, and tested them against pathogen species from the corresponding genera. AgNPs exhibited a size range of 15–40 nm for P. putida and 30–70 nm for E. coli, and both types of nanoparticles were surrounded by a thick biological corona layer, providing extreme stability. The nanoparticles remained stable over long periods and exhibited negative zeta potential values. P-AgNPs (obtained from P. putida) were tested against pathogenic Pseudomonas aeruginosa PAO1, and E-AgNPs (obtained from E. coli) were tested against pathogenic Escherichia coli UTI 89. Antimicrobial studies were conducted by Minimum bactericidal concentration (MBC), live/dead staining and SEM analysis. MBC of P-AgNPs against P. aeruginosa was 1 μg/mL, and MBC of E-AgNPs against E. coli UTI 89 was 8 μg/mL. In both cases, the MBC values were superior to those of green AgNPs produced in organisms unrelated to the target pathogens, available in the literature. Our results suggest that NPs produced in microorganisms closely related to the target pathogen may be more effective, indicating that the composition of the biological corona may play a crucial role in the antimicrobial mechanism of AgNPs.
Why open educational resources repositories fail : the contribution of quality approaches to the success of repositories

Clements, Kati Why Open Educational Resources Repositories Fail – the Contribution of Quality Approaches to the Success of Repositories University of Jyväskylä, 2016, 79p. (Jyväskylä Studies in Computing, ISSN 1456-5390; 233) ISBN 978-951-39-6587-7 (nid.) ISBN 978-951-39-6588-4 (PDF) Over the last two decades, millions of Open Educational Resources (OER) have become freely available for teachers and learners online. These resources are usually accessible through Learning Object Repositories (LORs), which are databases with a user interface. LORs are rarely used to their full potential and often considered as ‘failures’. Previous studies have shown that quality has a critical role in the success of information systems such as LORs. However there are no common guidelines for quality assurance approaches for LORs, nor are there studies into the contribution made by different LOR quality assurance approaches to the success of a repository. Measuring quality and success have proven to be a challenge in the research community due to the subjective and dynamic nature of such concepts. To meet this challenge, this thesis studied the perceptions of LOR users and developers with mutiple methodological perspectives. The contribution of this thesis to academic discourse comes from its deepening of the understanding of LOR users’ and developers’ perceptions on the quality and success of repositories. Frameworks for LOR quality assurance approaches and LOR success metrics were developed in order to identify and design approaches that would augment LOR success, as a theoretical contribution. The findings of these studies show that expert reviews combined with user-generated quality approaches (e.g. recommendation systems, peer reviews, commenting, tagging etc.) contribute towards LOR success. The practical contribution of this thesis is a set of recommendations towards the design of LOR quality approaches. These recommendations have already been used as guidelines for creating quality assurance approaches for four major European LORs.
Sports App: Digitalization of Sports Basic Movement

Sport is an activity that requires various aspects of support, with the habit that is often done. This study aims to produce a processing system for basic sports results or basic motor skills using a digital-based application for basic movement skills in sports. The research method used in this case is a research and development approach or method. The data collection method used in this study is a questionnaire given to respondents to obtain accurate data. While the data analysis used qualitative and quantitative data analysis to obtain valid and effective value data. The results in this study indicate that the data processing application system to determine the basic skills or basic abilities that were developed received a positive assessment from the trainer with very good and sufficient criteria. The average rating of very good is 37.5%, good is 50% and sufficient is as much as 12.5%. Furthermore, description by respondents shows that the data processing application system for the results of basic abilities or basic abilities is declared valid and can be used without revision and with revision. Based on the results of this study, it can be said that the developed system is valid and can be used to process basic motor skills possessed by athletes or students.
Knowledge, attitudes and practice toward cervical cancer screening and HPV vaccination among women in Bihar

Introduction: Cervical cancer is a major public health care burden. It can be prevented with proper screening if diagnosed early. Objective: This study aims to assess women’s knowledge on cancer cervix and its screening. To recognise the barriers preventing women to access the cervical cancer screening. To assess women s awareness on HPV vaccine. Method: Cross sectional study conducted in Kurji Holy Family hospital where 200 patients were chosen randomly and questionnaire filled by them to asses their knowledge on cerival cancer and its screening along with knowledge on HPV vaccination. Results: Majority of patients belonged to 45-60 years. Only 61 participants had heard of cervical cancer and only 9 of them were aware of HPV as a cause of cancer. 22% knew about pap smear with 1 % gaining knowledge from media. Only 37 participants knew about HPV vaccination. Post counselling 79% agreed for undergoing pap test and 41 agreed for get their vaccinated. Conclusion: In this study the knowledge of cervical cancer and pap smear is very poor but majority of participants showed positive attitude post counselling. Social media and the government needs to play active role in spreading awareness and improving accessibility among the women.
The effectiveness of vitamin D supplementation in reducing depressive symptoms: A systematic review and meta-analysis of Randomized Controlled Trials (RCTs)

BACKGROUND: Depression is a widespread, global problem, increasingly linked with vitamin D deficiency in the literature. However, a knowledge gap persists regarding the relationship between depressive symptoms and vitamin D intake. OBJECTIVE: To determine the association between vitamin D supplementation and depressive symptoms in adults (aged 18+ years). METHODS: This study consists of a systematic review and meta-analysis of randomized controlled trials (RCTs), published before January 2019. Pooled summary estimates and between-study heterogeneity were examined. RESULTS: Ten RCTs (total participants = 3336; median duration = 12 months) were included. An association was found between high vitamin D supplementation (≥4000 IU) and reduced depressive symptoms, but not in the case of lower levels of vitamin D supplementation (<4000 IU). Neither baseline serum vitamin D before supplementation, nor the depression-scoring scales used affected this association. The overall quality of evidence was graded as ‘moderate’. CONCLUSIONS: Vitamin D supplementation at greater than 4000 IU was observed to have a positive effect on depressive symptoms. Future efforts could focus on obtaining higher-quality evidence with standardized RCT methodologies to confirm this association.
Promoting transfer of hybrid training: Interaction of task‐contingent conscientiousness and supervisor support

Research on training has accumulated knowledge of factors influencing transfer of training. However, little is known about how these factors interact to impact training activity level and training transfer. Based on recent advances in the contingency approach to personality, we examine person – situation interaction by testing how task-contingent consci-entiousness influences trainees to utilize supervisor support differently during training and transfer. We situate the current investigation in hybrid management training courses where a field sample of employees ( N = 200) first attended required in-person workshops and then received voluntary online modules. Results show that task-contingent consci-entiousness moderated both the linkage between supervisor support and training activity level and the linkage between training activity level and transfer of training. Specifically, for trainees with higher task-contingent conscien-tiousness, supervisor support tended to have a stronger association with training activity level, and training activity level tended to translate into more transfer of training. Our findings provide unique insights into when supervisor support may be more beneficial depending on trainees' individual differences. We discuss the theoretical and practical implications of this research.
The Wellbeing Valuation Approach: The Monetary Value of Sport Participation and Volunteering for Different Life Satisfaction Measures and Estimators

This study applies the wellbeing valuation approach to sport participation and volunteering using data from the German Socio-Economic Panel. Linear regression results show that sport and volunteering hours increase satisfaction with life, health, work, income, and leisure, but with diminishing returns in most models. In a seemingly unrelated regression, some of these effects turn insignificant. The instrumental variable estimates show causal impacts of sporting hours on all wellbeing measures, while volunteering only impacts health satisfaction. The monetary values vary depending on the type of wellbeing measure and estimator, indicating that future studies should consider the employed measures and estimators.
Historical Border Changes, State Building, and Contemporary Trust in Europe

Political borders profoundly influence outcomes central to international politics. Accordingly, a growing literature shows that historical boundaries affect important macro-outcomes such as patterns of interstate disputes and trade. To explain these findings, existing theories posit that borders have persistent effects on individual-level behavior, but the literature lacks empirical evidence of such effects. Combining spatial data on centuries of border changes in Europe with a wide range of contemporary survey evidence, we show that historical border changes have persistent effects on two of the most politically significant aspects of behavior: individuals’ political and social trust. We demonstrate that in areas where borders frequently changed, individuals are, on average, less trusting of others as well as their governments. We argue that this occurs because border changes disrupt historical state-building processes and limit the formation of interpersonal social networks, which leads to lower levels of trust.
Optimal model evaluation of the proton-exchange membrane fuel cells based on deep learning and modified African Vulture Optimization Algorithm

ABSTRACT A new optimized design of a hybrid AlexNet/Extreme Learning Machine (ELM) network to provide an optimal identification tool for the Proton-exchange membrane fuel cells (PEMFCs) is presented in this study. The major concept is to reduce the error amount between the empirical output voltage and the evaluated output voltage of the PEM fuel cell stack model using the proposed hybrid AlexNet/ELM. For enhancing the model formation of the AlexNet/ELM, a modified version of the African Vulture Optimization (MAVO) Algorithm, which is a new metaheuristic, is suggested. To analyze the efficiency of the suggested method, it is applied to a practical PEMFC benchmark case study for identification purposes. Then, the method is confirmed by comparison of the experimental data and standard AlexNet/ELM. The achievements indicated the better confirmation of the suggested AlexNet/ELM network with the experimental data. The results show that the highest relative error for training and test is 0.03% and 0.05342%, respectively, which shows a promising result for the study.
Mechanical Properties and Microstructure of High-Strength Lightweight Concrete Incorporating Graphene Oxide

The increasing demand for high-strength lightweight concrete (HSLWC) with excellent mechanical properties has inspired the development of nanomaterials in fundamentally solving brittleness and cracking. This work investigated the effects of graphene oxide (GO) on the mechanical properties and microstructure of HSLWC, including the workability, density, compressive strength in different curing regimes, splitting tensile strength, flexural strength, modulus of elasticity and scanning electron microscopy (SEM). Six groups of mixtures were mixed with GO aqueous solution at a dosage of 0.00%, 0.02%, 0.04%, 0.05%, 0.06%, and 0.08% by weight of cement, respectively, and dispersed by ultrasound for 30 min. The test results showed that adding a low volume of GO to the specimens could slightly increase the density, rationally reduce the slump, and significantly improve the mechanical properties. The maximum increase in compressive strength, splitting tensile strength, modulus of elasticity and flexural strength of HSLWC with GO at 28 days was by 24%, 17%, 15%, 20%, respectively, as compared with HSLWC without GO. Simultaneously, the SEM results showed that GO could not only fill nano-scale pores, but also regulate the formation and growth of flower-like crystals, which was an important factor for the further improvement of properties. The research results provided a potential new pathway to improve the mechanical properties of HSLWC.
Periodontopathic Microbiota and Atherosclerosis: Roles of TLR-Mediated Inflammation Response

Atherosclerosis is a chronic inflammatory disease with a high prevalence worldwide, contributing to a series of adverse cardiovascular and cerebrovascular diseases. Periodontal disease induced by pathogenic periodontal microbiota has been well established as an independent factor of atherosclerosis. Periodontal microorganisms have been detected in atherosclerotic plaques. The high-risk microbiota dwelling in the subgingival pocket can stimulate local and systematic host immune responses and inflammatory cascade reactions through various signaling pathways, resulting in the development and progression of atherosclerosis. One often-discussed pathway is the Toll-like receptor-nuclear factor-κB (TLR-NF-κB) signaling pathway that plays a central role in the transduction of inflammatory mediators and the release of proinflammatory cytokines. This narrative review is aimed at summarizing and updating the latest literature on the association between periodontopathic microbiota and atherosclerosis and providing possible therapeutic ideas for clinicians regarding atherosclerosis prevention and treatment.
Decoupling between Economic Development and Carbon Emissions and Its Driving Factors: Evidence from China

Analyzing the relationship between economic development and carbon emissions is conducive to better energy saving and emission reduction. This study is based on the panel data of China’s carbon emissions, from 2009 to 2019, and quantitative analysis of the relationship between carbon emissions and economic development through the Tapio decoupling model and the Logarithmic Mean Divisia Index (LMDI) decomposition model. The results show that: First, carbon emission and economic development are increasing year by year, and the development trend of economic growth rate and carbon emission growth rate presents the characteristics of consistency and stage. Second, China’s carbon emissions and economic development are basically in a weak decoupling state, and carbon emissions and economic development are positively correlated. Third, there are significant differences in decoupling indices among the four regions, mainly in that the central region is better than the eastern region, the eastern region is better than the northeast region, the northeast region is better than the western region, and the development of provinces in the region is unbalanced. Fourth, from the perspective of driving factors, the elasticity of population size and economic intensity can restrain the decoupling of carbon emissions, while the elasticity of energy intensity and carbon intensity have a positive effect. Finally, according to the results of empirical analysis, this paper focuses on promoting China’s emission reduction and energy sustainable development from the aspects of developing low-carbon and zero carbon technology, supporting new energy industries and promoting the construction of a carbon emission trading market.
Direct observation of the non-locality of non-diffusive counter-gradient electron thermal transport during the formation of hollow electron-temperature profiles in the Large Helical Device

A heating source with off-axis electron cyclotron heating (ECH) alone produced a plasma with a quasi-steady-state hollow electron-temperature profile in the Large Helical Device. The clear formation of this quasi-steady-state hollow electron-temperature profile can be explained by adding the outward heat convection term to the diffusion term, as a simple model to describe the electron heat flux, using the energy conservation equation. In addition, we directly observed the non-locality of the non-diffusive (convective) contribution in transient electron thermal transport in the condition that power-modulated on-axis ECH was applied to the plasma sustained by off-axis ECH. The experimentally evaluated flux-gradient relation shows two different positive values of the electron heat flux at zero temperature gradient by going back and forth between positive and negative temperature gradient regions in the transport hysteresis phenomenon.
Adapting an Anthropomorphized Robot for Enhancing EFL Learning Motivation and Performance at an Elementary School in Taiwan

Th is study introduced an anthropomorphized robot-assisted instructional tool that we developed for English as a foreign language (EFL) learning and assessed the eﬀ ectiveness of robot-assisted English learning. An experimental design was adopted in this study and a total of 53 Taiwanese students in the third grade of elementary school participated in the experiment, including: one class consisting of 28 students, which was labeled as the experimental group, while another class of 25 students was labeled as the control group. Th ere were two kinds of data collection that were used in this study: two tests (listen-ing-and-acting as well as questioning-and-answering tests) and a questionnaire (learning material motivation scale). On the whole, the experimental group performed better than the control group on the listening-and-acting as well as on the questioning-and-answering tests. Additionally, the experimental group had higher learning material motivation than the control group, inclusive of attention, relevance, conﬁ dence, and satisfaction domains. Th e overall results suggest a new paradigm about our applications in teaching and learning English for Taiwanese EFL elementary school students.
Electrical Transport Measurements on Layered La(O,F)BiS2 under Extremely High Pressure

Layered La(O,F)BiS2 exhibits drastic enhancements of the superconducting transition temperature (Tc) under high pressure among the BiS2-based superconducting family. However, the high-pressure application beyond a high-Tc phase of the monoclinic structure has not been conducted. In this study, the electrical transport properties in La(O,F)BiS2 single crystal are measured under high pressures up to 83 GPa. An insulating phase without superconductivity is observed under a higher-pressure region above 16 GPa. Moreover, the sample exhibits metallicity and superconductivity above 60 GPa. The newly observed hidden semiconducting phase and reentrant superconductivity have attracted much attention in BiS2-based compounds.