Miracle-dz/UniFAR-FTUs huggingface dataset:
Differences in Auditory Perception Between Young and Older Adults When Controlling for Differences in Hearing Loss and Cognition

This study was designed to examine age effects on various auditory perceptual skills using a large group of listeners (155 adults, 121 aged 60–88 years and 34 aged 18–30 years), while controlling for the factors of hearing loss and working memory (WM). All subjects completed 3 measures of WM, 7 psychoacoustic tasks (24 conditions) and a hearing assessment. Psychophysical measures were selected to tap phenomena thought to be mediated by higher-level auditory function and included modulation detection, modulation detection interference, informational masking (IM), masking level difference (MLD), anisochrony detection, harmonic mistuning, and stream segregation. Principal-components analysis (PCA) was applied to each psychoacoustic test. For 6 of the 7 tasks, a single component represented performance across the multiple stimulus conditions well, whereas the modulation-detection interference (MDI) task required two components to do so. The effect of age was analyzed using a general linear model applied to each psychoacoustic component. Once hearing loss and WM were accounted for as covariates in the analyses, estimated marginal mean thresholds were lower for older adults on tasks based on temporal processing. When evaluated separately, hearing loss led to poorer performance on roughly 1/2 the tasks and declines in WM accounted for poorer performance on 6 of the 8 psychoacoustic components. These results make clear the need to interpret age-group differences in performance on psychoacoustic tasks in light of cognitive declines commonly associated with aging, and point to hearing loss and cognitive declines as negatively influencing auditory perceptual skills.
Plasma and Platelet Transfusion Strategies in Critically Ill Children Following Severe Trauma, Traumatic Brain Injury, and/or Intracranial Hemorrhage: From the Transfusion and Anemia EXpertise Initiative–Control/Avoidance of Bleeding

Supplemental Digital Content is available in the text. Objectives: To present consensus statements and supporting literature for plasma and platelet transfusions in critically ill children with severe trauma, traumatic brain injury, and/or intracranial hemorrhage from the Transfusion and Anemia EXpertise Initiative–Control/Avoidance of Bleeding. Design: Systematic review and consensus conference of international, multidisciplinary experts in platelet and plasma transfusion management of critically ill children. Setting: Not applicable. Patients: Critically ill neonates and children with severe trauma, traumatic brain injury, and/or intracranial hemorrhage. Interventions: None. Measurements and Main Results: A panel of eight experts developed expert-based statements for plasma and platelet transfusions in critically ill neonates and children with severe trauma, traumatic brain injury, and/or intracranial hemorrhage. These statements were reviewed and ratified by the 29 Transfusion and Anemia EXpertise Initiative–Control/Avoidance of Bleeding experts. A systematic review was conducted using MEDLINE, EMBASE, and Cochrane Library databases, from inception to December 2020. Consensus was obtained using the Research and Development/University of California, Los Angeles Appropriateness Method. Results were summarized using the Grading of Recommendations Assessment, Development, and Evaluation method. We developed one good practice statement and six expert consensus statements. Conclusions: The lack of evidence precludes proposing recommendations on monitoring of the coagulation system and on plasma and platelets transfusion in critically ill pediatric patients with severe trauma, severe traumatic brain injury, or nontraumatic intracranial hemorrhage.
Persistent Lyme disease with cutaneous Borrelia biofilm formation

Aurelie Halle iD , Alix De Becdelievre, Benoit Funalot, Christine Labr eze, Fanny Morice-Picard iD 3 and Franck Boralevi Department of Dermatology, Centre Hospitalier Universitaire d’Amiens, Amiens, France; Department of Medical Genetics, Henri Mondor University Hospital, AP-HP, INSERM, IMRB, Paris Est Cr eteil University, Cr eteil, France; and Department of Dermatology and Pediatric Dermatology, National Reference Centre for Rare Disorders, Hôpital des Enfants Pellegrin, Centre Hospitalier Universitaire de Bordeaux, Bordeaux, France Correspondence: Fanny Morice-Picard. Email: fanny.morice-picard@chu-bordeaux.fr
Application of Markov models to predict changes in nasal carriage of Staphylococcus aureus among industrial hog operations workers

Abstract Industrial hog operation (IHO) workers can be occupationally exposed to Staphylococcus aureus and may carry the bacteria in their nares. Workers may persistently carry S. aureus or transition between different states of nasal carriage over time: no nasal carriage, nasal carriage of a human-associated strain, and nasal carriage of a livestock-associated strain. We developed a mathematical model to predict the proportion of IHO workers in each nasal carriage state over time, accounting for IHO worker mask use. We also examined data sufficiency requirements to inform development of models that produce reliable predictions. We used nasal carriage data from a cohort of 101 IHO workers in North Carolina, sampled every 2 weeks for 4 months, to develop a three-state Markov model that describes the transition dynamics of IHO worker nasal carriage status over the study period and at steady state. We also stratified models by mask use to examine their impact on worker transition dynamics. If conditions remain the same, our models predicted that 49.1% of workers will have no nasal carriage of S. aureus, 28.2% will carry livestock-associated S. aureus, and 22.7% will carry human-associated S. aureus at steady state. In stratified models, at steady state, workers who reported only occasional mask (<80% of the time) use had a higher predicted proportion of individuals with livestock-associated S. aureus nasal carriage (39.2%) compared to workers who consistently (≥80% of the time) wore a mask (15.5%). We evaluated the amount of longitudinal data that is sufficient to create a Markov model that accurately predicts future nasal carriage states by creating multiple models that withheld portions of the collected data and compared the model predictions to observed data. Our data sufficiency analysis indicated that models created with a small subset of the dataset (approximately 1/3 of observed data) perform similarly to models created using all observed data points. Markov models may have utility in predicting worker health status over time, even when limited longitudinal data are available.
Nesting Biology and Offspring Development of the Cavity-Nesting Solitary Wasp Isodontia elegans (F. Smith) from Trap-Nests in Oregon

Abstract. We studied the nesting biology and developmental schedules of the cavity-nesting solitary wasp Isodontia elegans in Oregon, USA. Trap-nests contained 1–15 brood cells each, separated by partitions, which adult females made with grass fragments. Before leaving nests to hunt, females made loose, temporary closures of longer fragments of dried grass and, upon returning, briefly deposited prey just inside the nest entrance before transferring them to a cell. Cells were provisioned with katydids (Meconema thalassinum, an invasive species in North America) and tree crickets (Oecanthus fultoni), the latter predominating as summers progressed. The inner cells of nests, where most daughters developed, were longer and separated from adjacent cells by partitions thicker than those in outer cells, where most sons developed. These observations, along with the fact that daughters are larger than sons (likely because they receive a greater provision mass from mothers), indicate that investment in daughters is considerably greater than that in sons, by multiple measures. Sexual size dimorphism was evident in both cocoon mass (prepupae + cocoon case) and adult mass. From 2013 to 2019, nesting began earlier in the summer when mean maximum daily temperatures in June were higher and when the number of days in June with maximum temperatures <25 °C were fewer. Once nesting began, females typically completed 1 cell per day, the egg being laid on one of the first 3 prey placed in the cell. In the field, eggs hatched in 2–6 d, and larvae completed feeding and began cocoon spinning 5–11 d later. After removal from winter storage, offspring completing development at 29 °C emerged as adults in 22–40 d, with males emerging about 2 d earlier on average. The duration of the postdiapause period leading to adult emergence, however, was not correlated with eventual adult mass in either sex. We discuss interpopulation differences in prey species and nest materials used by I. elegans.
A Survey on Differential Privacy for Unstructured Data Content

Huge amounts of unstructured data including image, video, audio, and text are ubiquitously generated and shared, and it is a challenge to protect sensitive personal information in them, such as human faces, voiceprints, and authorships. Differential privacy is the standard privacy protection technology that provides rigorous privacy guarantees for various data. This survey summarizes and analyzes differential privacy solutions to protect unstructured data content before it is shared with untrusted parties. These differential privacy methods obfuscate unstructured data after they are represented with vectors and then reconstruct them with obfuscated vectors. We summarize specific privacy models and mechanisms together with possible challenges in them. We also discuss their privacy guarantees against AI attacks and utility losses. Finally, we discuss several possible directions for future research.
Left ventricular aneurysm: What is the role of surgical or percutaneous interventions?

• The chance of developing left ventricular (LV) aneurysm after anterior ST-segment myocardial infarction is reduced with ACE inhibitors, beta-blockers early (within 24 h of symptom onset) and rapid reperfusion. • Anterior LV aneurysm increases the risk of angina, heart failure, arrhythmia, stroke, and death. • LV partitioning with surgery or percutaneous devices improve LV volumes and ejection fraction, but trials have not yet proven sustained clinical benefits.
Siglec-5 is an inhibitory immune checkpoint molecule for human T cells

Sialic acid-binding immunoglobulin-type lectins (Siglecs) are a family of immunoglobulin-type lectins that mediate protein-carbohydrate interactions via sialic acids attached to glycoproteins or glycolipids. Most of the CD33-related Siglecs (CD33rSiglecs), a major subfamily of rapidly evolving Siglecs, contain a cytoplasmic signaling domain consisting of the immunoreceptor tyrosine-based inhibitory motif (ITIM) and immunoreceptor tyrosine-based switch motif (ITSM) and mediate suppressive signals for lymphoid and myeloid cells. While most CD33rSiglecs are expressed by innate immune cells, such as monocytes and neutrophils, to date, the expression of Siglecs in human T cells has not been well appreciated. In this study, we found that Siglec-5, a member of the CD33rSiglecs, is expressed by most activated T cells upon antigen receptor stimulation. Functionally, Siglec-5 suppresses T cell activation. In support of these findings, we found that Siglec-5 overexpression abrogates antigen receptor induced activation of Nuclear factor of activated T cells (NFAT) and Activator protein 1 (AP-1). Furthermore, we show that GBS β-protein, a known bacterial ligand of Siglec-5, reduces the production of cytokines and cytolytic molecules by activated primary T cells in a Siglec-5 dependent manner. Our data also show that some cancer cell lines express a putative Siglec-5 ligand(s), and that the presence of soluble Siglec-5 enhances tumor-cell specific T cell activation, suggesting that some tumor cells inhibit T cell activation via Siglec-5. Together, our data demonstrate that Siglec-5 is a previously unrecognized inhibitory T cell immune checkpoint molecule and suggests that blockade of Siglec-5 could serve as a new strategy to enhance anti-tumor T cell functions. One Sentence Summary: Siglec-5 is a novel checkpoint receptor expressed by activated human T cells that antagonizes TCR mediated activation and suppresses T cell effector functions such as cytokine production.
Heterogeneity of social cognition in temporo-parietal junction: Overlapping yet distinct representation between visual perspective-taking and theory of mind

Visual perspective taking (VPT), particularly level 2 VPT (VPT2), which allows an individual to understand that the same object can be seen differently by others, is related to the theory of mind (ToM), because both functions require a decoupled representation from oneself. Although previous neuroimaging studies have shown that VPT and ToM activate the temporo-parietal junction (TPJ), it is unclear whether common neural substrates are involved in VPT and ToM. To clarify this point, the present study directly compared the TPJ activation patterns of individual participants performing VPT2 and ToM tasks using functional magnetic resonance imaging and within-subjects design. VPT2-induced activations were compared with activations observed during a mental rotation task as a control task, whereas ToM-related activities were identified with a standard ToM localizer using false-belief stories. A whole-brain analysis revealed that VPT2 and ToM activated overlapping areas in the posterior part of the TPJ. By comparing the activations induced by VPT2 and ToM in individual participants, we found that the peak voxels induced by ToM were located significantly more anteriorly and dorsally within the bilateral TPJ than those measured during the VPT2 task. We further confirmed that these activity areas were spatially distinct from the nearby extrastriate body area (EBA), visual motion area (MT+), and the posterior superior temporal sulcus (pSTS) using independent localizer scans. Our findings revealed that VPT2 and ToM have distinct representations, albeit partially overlapping, indicating the functional heterogeneity of social cognition within the TPJ. Significance Statement The temporo-parietal junction (TPJ) is consistently activated by social cognitive tasks such as visual perspective taking (VPT) and theory of mind (ToM) tasks. The present study investigated whether VPT and ToM have the same neural substrates within the TPJ using functional magnetic resonance imaging (fMRI) with a within-subjects design. While VPT and ToM tasks activated overlapping areas in the posterior part of the TPJ, the individual peak voxels induced by ToM were located significantly more anteriorly and dorsally compared with those observed during the VPT task. Moreover, they were spatially distinct from the nearby functional modules, such as the extrastriate body area, visual motion area, and posterior superior temporal sulcus. Our findings reveal the heterogeneity of social cognition representation within the TPJ.
Structural basis of Omicron neutralization by affinity-matured public antibodies

The SARS-CoV-2 Omicron1 Variant of Concern (B.1.1.529) has spread rapidly in many countries. With a spike that is highly diverged from that of the pandemic founder, it escapes most available monoclonal antibody therapeutics2,3 and erodes vaccine protection4. A public class of IGHV3-53-using SARS-CoV-2 neutralizing antibodies5,6 typically fails to neutralize variants carrying mutations in the receptor-binding motif7–11, including Omicron. As antibodies from this class are likely elicited in most people following SARS-CoV-2 infection or vaccination, their subsequent affinity maturation is of particular interest. Here, we isolated IGHV3-53-using antibodies from an individual seven months after infection and identified several antibodies capable of broad and potent SARS-CoV-2 neutralization, extending to Omicron without loss of potency. By introducing select somatic hypermutations into a germline-reverted form of one such antibody, CAB-A17, we demonstrate the potential for commonly elicited antibodies to develop broad cross-neutralization through affinity maturation. Further, we resolved the structure of CAB-A17 Fab in complex with Omicron spike at an overall resolution of 2.6 Å by cryo-electron microscopy and defined the structural basis for this breadth. Thus, public SARS-CoV-2 neutralizing antibodies can, without modified spike vaccines, mature to cross-neutralize exceptionally antigenically diverged SARS-CoV-2 variants.
Structural and computational insights into the SARS-CoV-2 Omicron RBD-ACE2 interaction

Since SARS-CoV-2 Omicron variant (B.1.1.529) was reported in November 2021, it has quickly spread to many countries and outcompeted the globally dominant Delta variant in several countries. The Omicron variant contains the largest number of mutations to date, with 32 mutations located at spike (S) glycoprotein, which raised great concern for its enhanced viral fitness and immune escape[1–4]. In this study, we reported the crystal structure of the receptor binding domain (RBD) of Omicron variant S glycoprotein bound to human ACE2 at a resolution of 2.6 Å. Structural comparison, molecular dynamics simulation and binding free energy calculation collectively identified four key mutations (S477N, G496S, Q498R and N501Y) for the enhanced binding of ACE2 by the Omicron RBD compared to the WT RBD. Representative states of the WT and Omicron RBD-ACE2 systems were identified by Markov State Model, which provides a dynamic explanation for the enhanced binding of Omicron RBD. The effects of the mutations in the RBD for antibody recognition were analyzed, especially for the S371L/S373P/S375F substitutions significantly changing the local conformation of the residing loop to deactivate several class IV neutralizing antibodies.
Sorensen-dice similarity indexing based weighted iterative clustering for big data analytics

Big data is a collection of large volume of data and extract similar data points from large dataset. Clustering is an essential data mining technique for examining large volume of data. Several techniques have been developed for handling big dataset. However, with much time consumption and space complexity, accuracy is said to be compromised. In order to improve clustering accuracy with less complexity, Sørensen-Dice Indexing based Weighted Iterative X-means Clustering (SDI-WIXC) technique is introduced. SDI-WIXC technique is used for grouping the similar data points with higher clustering accuracy and minimal time. First, number of data points is collected from big dataset. Then, along with the weight value, the given dataset is partitioned into ‘X’ number of clusters. Next, based on the similarity measure, Weighted Iterated X-means Clustering (WIXC) is applied for clustering data points. Sørensen-Dice Indexing Process is used for measuring similarity between cluster weight value and data points. Upon similarity found between weight value of cluster and data point, data points are grouped into a specific cluster. Besides, the WIXC method also improves the cluster assignments through repeated subdivision using Bayesian probability criterion. This in turn helps to group all data points and hence, improving the clustering accuracy. Experimental evaluation is carried out with number of factors such as clustering accuracy, clustering time and space complexity with respect to the number of data points. The experimental results reported that the proposed SDI-WIXC technique obtains high clustering accuracy with minimum time as well as space complexity.
Sleep-Dependent Anomalous Cortical Information Interaction in Patients With Depression

Depression is a prevalent mental illness with high morbidity and is considered the main cause of disability worldwide. Brain activity while sleeping is reported to be affected by such mental illness. To explore the change of cortical information flow during sleep in depressed patients, a delay symbolic phase transfer entropy of scalp electroencephalography signals was used to measure effective connectivity between cortical regions in various frequency bands and sleep stages. The patient group and the control group shared similar patterns of information flow between channels during sleep. Obvious information flows to the left hemisphere and to the anterior cortex were found. Moreover, the occiput tended to be the information driver, whereas the frontal regions played the role of the receiver, and the right hemispheric regions showed a stronger information drive than the left ones. Compared with healthy controls, such directional tendencies in information flow and the definiteness of role division in cortical regions were both weakened in patients in most frequency bands and sleep stages, but the beta band during the N1 stage was an exception. The computable sleep-dependent cortical interaction may provide clues to characterize cortical abnormalities in depressed patients and should be helpful for the diagnosis of depression.
Associations Between Maladaptive Perfectionism and Life Satisfaction Among Chinese Undergraduate Medical Students: The Mediating Role of Academic Burnout and the Moderating Role of Self-Esteem

Empirical research has shown that maladaptive perfectionism may lead to lower life satisfaction. However, the relationship between maladaptive perfectionism and life satisfaction among medical students and the mechanism underlying this relationship still need to be further explored. The present study used a large sample of undergraduate medical students to examine the associations between maladaptive perfectionism and life satisfaction and to explore the mechanism underlying the associations. Specifically, the present study tried to probe the mediating role of academic burnout and the moderating role of self-esteem in the relationship between maladaptive perfectionism and life satisfaction in medical students. We invited 1628 undergraduate medical students from two medical universities in Northeastern China to participate in the survey. Among the students recruited, 1377 medical students (response rate: 84.6%) completed questionnaires including the Frost Multidimensional Perfectionism Scale (FMPS) maladaptive perfectionism subscales, the Chinese College Student Academic Burnout Inventory (CCSABI), the Satisfaction With Life Scale (SWLS), the Rosenberg Self-Esteem Scale (RSES) and demographic information. Results show that maladaptive perfectionism was significantly negatively related to life satisfaction among medical students and academic burnout played a significant mediating role (β = −0.10, BCa 95%CI: −0.12, −0.07) in this relationship. Moderated mediation analyses reveal that the mediating effect of maladaptive perfectionism on life satisfaction via academic burnout was moderated by self-esteem. Maladaptive perfectionism exerted a stronger effect on life satisfaction via the mediating role of academic burnout for medical students with high self-esteem [β = −0.026, SE = 0.009, 95%CI = (−0.047, −0.011)] than for medical students with low self-esteem [β = −0.019, SE = 0.009, 95%CI = (−0.038, −0.001)]. Medical institutions can implement effective interventions to decrease medical students’ maladaptive perfectionism levels and academic burnout levels, and increase their self-esteem levels in order to enhance their life satisfaction.