Miracle-dz/UniFAR-FTUs huggingface dataset:
Analysis of risk factors of recurrence of pT1-3N0M0 esophageal squamous cell carcinoma after two-field esophagectomy

Objective To retrospectively analyze the factors of postoperative recurrence of stage pT1-3N0M0 esophageal squamous cell carcinoma. Methods A total of 488 patients who underwent two-field R0 esophagectomy, pathologically classified as stage pT1-3N0M0, without adjuvant radiotherapy and/or chemotherapy before or after surgery and postoperative survival time≥ 3 months were enrolled in this study. Multivariate analysis was performed by using Cox model. Results At the end of follow-up, the overall recurrence rate was 36.9%(180/488); the local recurrence rate was 21.5%(105/488), the distant metastasis rate was 6.8%(33/488) and the local recurrence rate complicated with the distant metastasis rate was 8.6%(42/488). Cox multivariate analysis demonstrated that tumor site and pT staging were the factors affecting the overall/local recurrence rate and distant metastasis. The recurrence rate in patients with the upper esophageal squamous cell carcinoma and stage pT3 was the highest, followed by those with the middle esophageal squamous cell carcinoma or stage pT2 and the lowest recurrence rate was observed in patients with the lower esophageal squamous cell carcinoma or stage pT1. Conclusions Tumor site and pT staging are the pivotal factors for postoperative recurrence of stage pT1-3N0M0 esophageal squamous cell carcinoma after two-field R0 esophagectomy, which contributes to offer guidance to the selection of indications for postoperative adjuvant radiotherapy. Key words: Esophageal neoplasm/surgery; Esophagectomy/two-field; Recurrence
The latitudinal variation of the charge exchange induced atomic hydrogen escape flux. [in ionosphere]

Using plasma data from the Isis 2 spacecraft and Arecibo radar, diffusive equilibrium models of the ionosphere were constructed for equinox conditions. These plasmaspheric models were combined with models of the neutral atmosphere ot calculate the atomic hydrogen escape flux due to charge exchange between thermal protons and to calculate cooler hydrogen and oxygen atoms as a function of dipole latitude and local time. These calculations showed that the daytime escape flux increases as the absolute value of the dipole latitude decreases, reaching its maximum value at the magnetic equator. At 15 hours local time (LT) on March 23, 1972, the calculated escape flux varied from an insignificant amount at 55/sup 0/ dipole latitude, to 3 x 10/sup 8/ atoms cm/sup -2/ s/sup -1/ at the magnetic equator. In addition, the relative importance to the total charge-exchange escape flux of the component due to charge exchange between protons and atomic oxygen is discussed. The contribution to the escape flux of plasma at high L values, and the effect of newly produced hot hydrogen upon the neutral temperature are also discussed.
Mixing and reactions in porous media

In this thesis we use a stochastic approach to address the upscaling of mixing dominated reactions in flows thorough heterogeneous porous media. For the case where the transport is represented only by diffusion, fluctuations in spatial concentration distribution lead to segregation of chemicals and thus to anomalous kinetics. We show that the transition from the expected behavior shown by well mixed systems to this anomalous kinetics is intimately linked to the evolution of the concentration PDF from a Gaussian to non-Gaussian shape. This fact establishes a direct relationship between anomalous reaction kinetics, incomplete mixing and the non-Gaussian nature of the concentration PDF. Introducing advective transport processes in our analysis, we studied the impact of incomplete mixing on effective reaction kinetics at the front between two solutes, one displacing the other, in a 2d heterogeneous porous medium. While classical Fickian models predict a scaling for the mass production as t12 , we show that the kinetics follow 2 non-Fickian regimes. An early times the invading reactant is organized in fingers and the mass production scales as t2. For later times the mass production slows down, but it is still faster then the t 1 2 . It does not depends on diffusion and is totally controlled by advective spreading. In this regime, anomalous kinetics is directly related to superdiffusive advective spreading. In order to relate the pore scale flow heterogeneity to advective spreading and subsequently to anomalous kinetics, we analyze the distribution and correlation of Lagrangian velocities. We show the existence of long range temporal correlation of Lagrangian accelerations, which are at the root of the breakdown of classical Fickian dispersion models. Thus, similarly to turbulent media, flow through porous media displays strong intermittent properties. We demonstrate that they can be quantified by a correlated Continuous Time Random Walk approach, which provides a consistent upscaling framework. We finally perform a laboratory experiment where a quasi 2D system is studied through an Hele-Shaw cell in which two reactive chemicals are injected, one displacing the other. A new experimental set up based on chemiluminescence reactions allows high resolution quantification of the pore scale concentration pdf and reaction rate. The anomalous kinetics of the reactive front is observed and is very consistent with our theoretical predictions.
Chemical and physical properties

VOLUME 2: CHEMICAL and PHYSICAL PROPERTIES This volume consists of entries from 11 fields. It provides related chemical and physical data commonly used to support a wide variety of needs ranging from chemical research to regulatory activities involving Material Safety Data Sheet (MSDS) preparation and shipping. The data fields include the following: Chemical formula Molecular weight Wiswesser Line Notations (WLN) Physical description Specific gravity Density Melting point Boiling point Solubility Other solvents Other physical data
Air pollution and turbulence : modeling and applications

Deposition, Transformation, and Remobilization of Soot and Diesel Particulates on Building Surfaces, P. Brimblecombe and C.M. Grossi Atmospheric Boundary Layer: Concepts and Measurements, G. Fisch Turbulence and Dispersion of Contaminants in the Planetary Boundary Layer, G.A. Degrazia, A. Gledson Oliveira Goulart, and D.R. Roberti Parameterization of Convective Boundary Layer Turbulence and Clouds in Atmospheric Models, P.M. M. Soares, J. Teixeira, and P.M.A. Miranda Mathematical Air Pollution Models: Eulerian Models, T. Tirabassi Analytical Models for the Dispersion of Pollutants in Low Wind Conditions, P. Kumar and M. Sharan On the GILTT Formulation for Pollutant Dispersion Simulation in the Atmospheric Boundary Layer, D.M. Moreira, M. Tullio M. B. de Vilhena, and D. Buske An Outline of Lagrangian Stochastic Dispersion Models, D. Anfossi and S.T. Castelli Atmospheric Dispersion with a Large-Eddy Simulation: Eulerian and Lagrangian Perspectives, U. Rizza, G. Gioia, G. Lacorata, C. Mangia, and G.P. Marra Photochemical Air Pollution Modeling: Toward Better Air Quality Management, C. Borrego, A.I. Miranda, and J. Ferreira Inversion of Atmospheric CO2 Concentrations, I.G. Enting Index
Characteristics of Entrepreneurs, Entrepreneurial Finance, and Growth Paths

The aim of this paper is to better understand how entrepreneurial equity finance interacts with the complex growth process of young technological ventures. More specially, we investigate how different growth paths are influenced by the entrepreneurs’ interactions with different categories of private equity investors, namely business angels (BAs) and formal venture capitalists (VCs). Through a comparative case-study contrasting one hyper-growth venture with one moderate growth venture, we show that growth paths depend strongly on the entrepreneurs being more or less able to simultaneously leverage BAs’ and VCs’ financial as well as cognitive resources. The entrepreneurs ‘capability to do so, is shown to be dependent on their specific psychological and cognitive characteristics as well as on their decision making style.
FUNGICIDAL ACTIVITY OF GARLIC (Allium sativum) BULBS EXTRACTS AGAINST PLANTS PHATOGENIC FUNGI

Fungicidal activity of garlic (Allium sativum) bulbs extracts against plants phatogenic fungi. Garlic (Allium sativum Linn) has been known to containing organosulphur compounds. These compounds are convinced to possess antibacterial, antifungal, and anticancer activities. The aim of this study is to determine fungicidal activity of garlic bulb extracts against some plants phatogenic fungi. The paper disc agar difussion technique was used to determine fungicidal activity of garlic bulbs extracts. The results showed that in general garlic bulbs extracts provides fungicidal activities. Calculated EC50 values indicated that ethyl acetate garlic bulbs extract was most active against Colletotrichum capsici, Fusarium oxysporum f. sp.capsici, and Sclerotium rolfsi by EC50 values of 48,6; 50,3; and 51.3% respectively. Meanwhile methanolic garlic bulbs extract was the most active against Sclerotium rolfsi with EC50 values of 24,3%.
The Strategy to Improve Religious Services for Religious Minorities

: Religious service for minorities is the subject that has been heavily discussed within the Shariah framework. The Constitution guarantees freedom of religion and worship without exception, including religious services for minorities such as the establishment of place of worship, recording of marriages and births, funerals, and identity cards issuance. Neglecting minority rights in the context of religious services is a serious problem found in several provinces in Indonesia. The lack of attention to minority communities can be seen as a form of ignoring citizenship rights. This can also be seen as an act of neglecting the constitutional mandate that guarantees every citizen to get an equal treatment by the government. To improve religious services for religious minorities, there is a need for a new paradigm approach and strategy in order to cut down on constraints and barriers for giving the services needed. This study aims to better uncover the problems of religious services for religious minorities along with the social context behind it, propose new strategies to improve the existing policies, and developed programs that can be implemented as a solution for the improvement.
Filtering of interstellar dust in the heliosphere

Der Raum zwischen den Sternen enthaelt Gas und interstellarem Staub (IS), die mit astronomischen Methoden, sowie durch in-situ Messungen von Raumsonden im Sonnensystem beobachtet werden. Jedoch existieren noch viele Fragen ueber die Zusammensetzung, die Morphologie und Groessenverteilung des IS, welche mehr und verbesserte Messungen erforderen. Um diese Beobachtungen zu interpretieren wird ein besseres Verstaendnis des IS-Flusses durch das Sonnensystem benoetigt. Auch ist die Modellierung fuer die Gestaltung und Optimierung zukuenftiger Missionen mit IS Messungen notwendig. Diese Arbeit modelliert den Fluss des IS durch das Sonnensystem unter Beruecksichtigung der Gravitation und des Strahlungsdrucks der Sonne und der Lorentz-Kraft, die aus der Bewegung der geladenen Koerner im interplanetaren Magnetfeld resultiert. Der Einfluss dieser Kraefte auf die Bahnen, Dichten und Fluesse wurde systematisch durch Simulation von Staubtrajektorien ueber einen grossen Bereich von IS-Eigenschaften untersucht. Auch die IS-Groessenverteilung im Sonnensystem haengt stark von den Staubeigenschaften, der Position im Sonnensystem und der Zeit im solaren Zyklus ab. Solche modifizierten Groessenverteilungen werden fuer feste Positionen entlang der IS Stroemungsachse und fuer sich bewegende Objekte wie Saturn, Jupiter und den Main-Asteroid Ceres diskutiert. Die Auswirkungen fuer die spezifischen Missionen Cassini, JUICE und Stardust werden untersucht. Die Vorhersage des IS-Fusses fuer Cassini zeigt, dass zwischen 2010 und 2017 der Fluss fuer kleine Teilchen maximal ist. Fuer JUICE zeigen die Simulationen, dass es eine optimale Gelegenheit fuer IS Beobachtungen im Jahr 2030 gibt. Schliesslich werden die Simulationensergebnisse fuer die Stardust Mission mit den vorlaeufigen Ergebnissen (IS Proben) des Stardust Teams verglichen. Die Beobachtungen koennen zwar nicht als Beweis erachtet werden, sind aber durchaus kompatibel mit einem interstellaren Ursprung der IS Kandidaten.
Use of FFPE-derived DNA in next generation sequencing: DNA extraction methods

Archival tissues represent a rich resource for clinical genomic studies, particularly when coupled with comprehensive medical records. Use of these in NGS is a priority. Nine formalin-fixed paraffin-embedded (FFPE) DNA extraction methods were evaluated using twelve FFPE samples of varying tissue types. Quality assessment included total yield, percent ds DNA, fragment analysis and multiplex PCR. After assessment, three tissue types from four FFPE DNA methods were selected for NGS downstream evaluation, whole exome (WES) and targeted sequencing. In addition, two low input library protocols were evaluated for WES. Analysis revealed average coverage across the target regions for WES was ~20-30X for all four FFPE DNA methods. For the targeted panels, the highest molecular tag coverage was obtained with the Kingfisher FFPE extraction method. The genotype concordance was 99% for the commonly called variant positions between all four extraction methods with the targeted PCR NGS panel and 96% with WES.
Intermittent hypoxia-induced cell proliferation via upregulations of interleukin-6 and epiregulin

Background: Sleep apnea syndrome (SAS) is characterized by repetitive episodes of oxygen desaturation and re-saturation, such as intermittent hypoxia (IH), and well known as an independent risk factor for atherosclerosis. In this study, we investigated direct impact of IH on vascular smooth muscle cells [human coronary artery smooth muscle cells (hCASMCs) and cultured rat aorta smooth muscle cells (RASMCs)], using in vitro IH system. Methods: hCASMC were exposed to normoxia (21% O2, 5% CO2, and balance N2), sustained hypoxia (1% O2, 5% CO2, and balance N2) or IH (indicated cycles of 10 min normoxia and 5 min sustained hypoxia). Cell proliferation was estimated by WST-8 assay. Expression of mRNAs was measured by quantitative RT-PCR. The concentrations of IL-6 in the medium of IH-exposed cells were measured by enzyme linked immunosolvent assay. siRNA method was used for knockdown of IL-6 and IL-6 receptor mRNAs. Results: WST-8 assay revealed that IH directly induced RASMC proliferation. In further investigation, we found that epidermal growth family, especially epiregulin (EREG), and erbB2 receptor increased in IH but not in sustained hypoxia. In addition, the IH-induced RASMC proliferation was inhibited by an erbB2 receptor specific inhibitor in a concentration dependent manner. These findings suggested that IH induces RASMC proliferation through increases of EREG and erbB2 receptor. However, its underlying mechanism remained unclear. For further investigation, we used hCASMCs. In hCASMCs, IH-induced increase of EREG mRNA was observed as well as in RASMCs. IH also induced upregulations of IL -6 mRNA and mature IL-6 with IH cycle dependent manner. The addition of IL-6 into cell culture medium increased the expression of EREG mRNA. In addition, siRNAs for IL-6 and IL-6 receptor suppressed the IH-induced increase of EREG mRNA expression. Conclusions: These results indicated that IL-6 plays a pivotal role in EREG upregulation by IH and consequently SAS-related atherosclerosis and suggests a possible mechanism of atherosclerosis as a complication in SAS patients.
Quantile Regression Facilitates Simultaneous Selection of Negatively Correlated Floral Traits among BC1F1 Progeny of Male-fertile Hybrid Hibiscus Cultivars Lohengrin and Resi (H. syriacus × H. paramutabilis)

Hibiscus syriacus is a woody shrub in the Malvaceae family that is common in landscapes due to its broad adaptability and variable ornamental characteristics. Interspecific hybridization has been used to improve Hibiscus by building novel floral traits, hybrid vigor, and hybrid infertility. A few interspecific hybrid Hibiscus cultivars (H. syriacus × H. paramutabilis), such as Lohengrin and Resi, are notable because of their vigorous vegetative growth, female infertility, and large flowers. However, little is known about the male fertility and breeding potential of these hybrid cultivars, which could increase flower size by backcrossing to H. syriacus. In this study, we estimated male fertility of the two hybrid cultivars by acetocarmine staining and in vivo pollination and assessed selection methods for floral traits, specifically flower size and petal number. A BC1F1 population of 294 individuals was developed by crossing hybrid cultivars Lohengrin or Resi with a variety of double-flowered H. syriacus cultivars. A negative correlation between petal number and petal area was detected by quantile regression, which is a method that circumvents the problem of simple linear regression, which violates statistical assumptions. Quantile regression was used to build simultaneous selection thresholds for different levels of required stringency. As expected, the female fertility of hybrid cultivars was extremely low or zero; however, the male fertility of hybrid cultivars was not reduced compared with H. syriacus cultivars. A negative linear correlation between the petal number and petal area of the BC1F1 individuals was observed. In addition, quantile regression was recommended to set a single selection threshold to be applied to the selection of two negatively correlated traits, which was more effective than independent selection of petal numbers and petal areas among progeny.
The Correlation of Fasting and 2-Hours Postprandial Plasma Glucose with Glycated Hemoglobin as Glycemic Control

: Diabetes Mellitus (DM) is one of the non-communicable diseases that are currently increasing in number. One of the indicators that used to describe the longer period of glycemic control in patients with DM is the level of glycated hemoglobin or HbA1c. The purpose of this study was to determine whether in fasting or 2-hours postprandial plasma glucose (PPG) level correlated with HbA1c level. So it can be used as the glycemic control when measurement of the HbA1c is not available. This study is a cross-sectional study, on 60 type 2 diabetes mellitus patients at the University of Sumatera Utara Hospital. Before the examination, respondents are required to fast for 10-12 hours. Examination of fasting plasma glucose (FPG) and 2-hours PPG were performed using a cobas 6000 analyzer with hexokinase and immunoturbidimetry method. HbA1c was measured using high-performance liquid chromatography (HPLC) method. The correlation between FPG with HbA1c and 2-hours PPG with HbA1c was analyzed with the Spearman bivariate correlation test by SPSS 22 version. We found that the mean and SD values of FPG, 2-hours PPG, and HbA1c were 186.31 ± 71.27, 284.88 ± 92.06 and 8.85 ± 1.73, respectively. The Spearman bivariate correlation indicated a significant association (p = 0.005, r = 0.357) between FPG with HbA1c. In this study found that no correlation between 2-hours PPG with HbA1c (p = 0.780, r = 0.036). We conclusions, FPG indicated as glycemic control better than 2-hours PPG on type 2 diabetic if the HbA1c examination is not available.
Addition of residues with different C/N ratio in soil over time individually or as mixes - effect on nutrient availability and microbial biomass depends on amendment rate and frequency

Residues with different properties may be added to soil simultaneously (as mixes) or after each other. In most previous studies on the effect of mixes on decomposition and nutrient release, residues were added once at the start of the experiment. Less is known about the effect of mixtures added more than once on soil respiration, microbial biomass and nutrient availability and how the addition frequency influences interactions between high C/N (H) and low C/N (L) residues in mixes. In the 48-day incubation experiment with total amendment rate in all treatments was 20 g kg-1, treatments differed in addition frequency (twice, four or eight times), rate (10, 5 or 2.5 g kg-1) as well as order of H and L. Soil was sampled every 12 days. Treatments had similar total cumulative respiration, but differed in distribution over the 12 day periods. Available N and MBN changed strongly over time in treatments with 10 or 5 g kg-1, depending on the C/N ratio of the residue added before sampling. Frequent addition of small amounts of residues (2.5 g kg-1) limited microbial N uptake initially compared to higher amendment rates, but resulted in similar available N irrespective of the C/N ratio of the residue added. It can be concluded that with less frequent residue addition, microbes decompose mainly the recently added residue. With more frequent addition, microbes decompose recently added residue together with residue added before the most recent amendment.
Service Quality as Mediation Variable between Online Transportation Image and Interaction Quality and Consumer Satisfaction

: This study discusses service quality as a mediating variable between corporate image and quality of interaction with customer satisfaction. This study was conducted on consumers of online transportation services in Purwokerto. The sample size for the study was 105 respondents. Data analysis techniques were done by path analysis with AMOS software. The results of data analysis obtained consumer satisfaction influenced by the quality of service. Service quality is influenced by the company's image and the quality of interaction. Service quality is able to be a mediating variable between company image and interaction quality.
Predisposing Factor Associated with Community Action in Terminating TB Transmission in KB Village 2018

: The purpose of KB village is to improve the degree of public health. Pulmonary TB is a disease with high prevalence and degrade the public health and welfare level. This study aims to analyze the relationship of predisposing factor with knowledge, attitude, and community action in terminating pulmonary TB transmission with cross-sectional design. The population is all households from two neighborhoods of KB Village of 204 households. The sample is taken randomly from the list of households and got 132 respondents and analyzed using independent t-test. The proportion of respondent’s factor was female (93.9%), age ≤ 50 years (71.2%), lower education (59.1%), unemployment (72.7%), and less dense population (65.9%). It is obtained gender, age, and occupation are significantly related with knowledge (p<0.05). Only employed is related with attitude (p<0.05) and gender is related with action (p<0.05). Intensive counseling is needed for the people of KB Village to improve their attitude and action in effort of terminating pulmonary TB transmission. The role of cadre in KB Village have to improve in order to give understandable counseling and can be applied by the community, therefore an effective and efficient counseling method is being prepared by utilizing poster and cadre’s book guideline.