Miracle-dz/UniFAR-FTUs huggingface dataset:
The relationship between physical activity and polypharmacy with Ikigai in a population

The aim: The Japanese word “ikigai” indicates “something to live for” and “having a purpose in life”. Ikigai or well-being, has been associated with many positive outcomes in the physical and mental health of elderly people. In this study, the relationship between ikigai and level of physical activity and polypharmacy was examined in a Turkish population. Material and methods: Both telephonic interviews and face-to-face interviews were conducted with 307 participants (59.2 % women) who completed the Ikigai-9 Turkey Scale and provided demographic information. Results: Correlations between groups (polypharmacy vs. non-polypharmacy) were analyzed with an independent t-test and analysis of variance. The means of the ikigai scores were statistically significant in the polypharmacy (24.04±8.72) and non-polypharmacy 32.64±7.53) groups (p<0.05). The number of drugs used was negatively correlated with duration of exercise per week (1.32±1.82, correlation coefficient = 0.538, p<0.05). Conclusions: The level of ikigai was negatively correlated with polypharmacy and positively correlated with duration of physical activity. An individual’s ikigai should be assessed by healthcare providers to maximize positive outcomes later in life
Hybrid metaheuristics for solving multi-depot pickup and delivery problems

In today's logistics businesses, increasing petrol prices, erce competition, dynamic business environments and volume volatility put pressure on logistics service providers (LSPs) or third party logistics providers (3PLs) to be e cient, di erentiated, adaptive, and horizontally collaborative in order to survive and remain competitive. In this climate, e cient computerised-decision support tools play an essential role. Especially, for freight transportation, e ciently solving a Pickup and Delivery Problem (PDP) and its variants by an optimisation engine is the core capability required in making operational planning and decisions. For PDPs, it is required to determine minimum-cost routes to serve a number of requests, each associated with paired pickup and delivery points. A robust solution method for solving PDPs is crucial to the success of implementing decision support tools, which are integrated with Geographic Information System (GIS) and Fleet Telematics so that the exibility, agility, visibility and transparency are fullled. If these tools are e ectively implemented, competitive advantage can be gained in the area of cost leadership and service di erentiation. In this research, variants of PDPs, which multiple depots or providers are considered, are investigated. These are so called Multi-depot Pickup and Delivery Problems (MDPDPs). To increase geographical coverage, continue growth and encourage horizontal collaboration, e ciently solving the MDPDPs is vital to operational planning and its total costs. This research deals with designing optimisation algorithms for solving a variety of real-world applications. Mixed Integer Linear Programming (MILP) formulations of the MDPDPs are presented. Due to being NP-hard, the computational time for solving by
Dating apps: a literature review

ABSTRACT Dating apps have become one of the most prominent and contentious topics in the realm of intimacy among the wider public and academia. Media and communication researchers have examined their uptake across cultural contexts, seeking to address the dynamics between dating apps and social processes. With the knowledge accumulated in this research field, we assemble a comprehensive account of interactions through dating apps. We categorize existing findings about dating apps into three sections: dating apps and their reconfiguration, dating practices and their remediation, and lastly social arrangements and their reformation. These sections together present dating apps as a technological consequence of various social forces that mediate users’ daily practices and social relationships.
Continuation of Teletherapy After the COVID-19 Pandemic: Survey Study of Licensed Mental Health Professionals

Background The use of teletherapy has exponentially increased in the context of the ongoing COVID-19 pandemic. Studies on teletherapy documented substantial benefits of accessibility and convenience even before the start of the pandemic. Although recent studies show that this modality of therapy delivery is here to stay, few have studied who will most benefit from this trend. Objective In this paper, we report predictors of continued teletherapy usage in a sample of licensed mental health professionals in the United States during a time period when pandemic-related restrictions began diminishing. As such, it is one of the first studies to examine factors related to continued benefits of teletherapy postpandemic. Methods Participation from licensed mental health professionals was sought on listservs of national organizations of multiple mental health organizations. Data were collected via an anonymous link to a survey on Qualtrics between January 2021 and April 2021. Participants responded to questions on therapist demographics, practice setting, experiences of shifting to teletherapy, perspectives on continued use of teletherapy, and their client characteristics. Findings related to client characteristics that predicted continued teletherapy usage are presented here. Results A total of 186 individuals consented to participate in the survey, with a final sample of 114 with complete data. A majority of participants identified as female (92/114, 80.7%), White (94/114, 82.5%), and having a master's degree (75/114, 65.5%) from a nationally accredited program (106/114, 93%). Data were analyzed using heteroskedastic regression modeling with client-related factors as predictors. Two models were run with and without distance travelled by clients as a control variable. Model estimates from both models showed that continued use of teletherapy postpandemic was predicted by the following factors: higher percentage of clients from rural areas, younger and older adult clients, clients with Medicare, and clients with marginalized gender and religious/spiritual identities. Significantly, having a higher percentage of clients from lower socioeconomic status, a higher percentage of those with Medicaid coverage, and a higher percentage of couples and families as clients predicted decreased use of teletherapy postpandemic. Conclusions Findings from the study suggest that while some groups of clients are more likely to continue to receive benefits of teletherapy, vulnerable groups such as those in lower socioeconomic conditions, Medicaid beneficiaries, and those who seek couple and family therapy may be less likely to be served by it. These differences point to a need to address factors driving telehealth care disparities such as access to technology, housing, and childcare issues, as well as the need for continued training for licensed professionals.
Febrile illness of bacterial etiology in a public fever hospital in Egypt: High burden of multidrug resistance and WHO priority Gram negative pathogens.

Introduction Contemporary emergence of multidrug resistance (MDR) urges regular updates on circulating pathogens and their antimicrobial resistance profiles. We aimed to identify the burden of MDR and World Health Organization (WHO) priority Gram negative pathogens among patients admitted with febrile illness to Abbassia Fever Hospital, a major Public Fever Hospital in Egypt. The carbapenemase- and extended spectrum beta-lactamases (ESBLs)-encoding genes carried by the isolates were also identified. Methods A total of 9602 clinical specimens were collected from febrile patients during 2018 and 2019. The recovered bacterial isolates were examined for antimicrobial susceptibility using disk diffusion test. Susceptibility to colistin was tested using E-test. ESBLs production was phenotypically and genotypically analyzed. Results A total of 790 bacterial isolates (612 Gram negative and 178 Gram positive) were recovered. A percentage of 77.6%, and 62.9% of the Gram negative and positive isolates showed MDR phenotype, respectively. WHO priority pathogens were abundant, including carbapenem-resistant (CR) Enterobacterales (105/187; 56.1%) and CR glucose non-fermenters (82/187; 43.8%) such as: A. baumannii (55; 29.4%), P. aeruginosa (27; 14.4%). Carbapenemase- and ESBLs-encoding genes were detected in 56.1% and 30.8% of Enterobacterales and in 43.8% and 46.3% of glucose non-fermenters, respectively. Antimicrobials such as fosfomycin and chloramphenicol retained good activities against MDR Gram negative pathogens. Conclusions This study highlights the regional burden of MDR and priority Gram negative pathogens. The obtained data are of relevant medical importance for implementation of evidence-based antimicrobial stewardship programs and for tailoring the existing empirical treatment guidelines.
Local government’s response to dissatisfaction with centralized policies: the “do-it-yourself” approach

The literature on intergovernmental relationships discusses the tension between centralization and local autonomy. However, few studies question local authorities’ response when dissatisfied with central government policies. Using Hirschman's model of exit, voice and loyalty, we explore local government's response to such dissatisfaction. Specifically, we suggest that local authorities may adopt a “do-it-yourself” approach, unilaterally engaging in semi-legal strategies to improve outcomes. This solves immediate local organizational problems, without waiting for approval. Using the Israeli case, we show how a pervasive culture of “do-it-yourself” affects local governments’ responses. We also discuss implications for the relationship between the two bodies. Points for practitioners Our findings shed light on local–central government relations, emphasizing the do-it-yourself approach. While this approach could strengthen political participation, increasing local government's involvement in public policy, it also enables local players to use semi-legal behaviors. Central government decision-makers might prevent these behaviors, strengthening administrative institutions’ enforce, regulatory enforcement and enhancing local autonomous political culture, transparency and integrity. By contrast, continuing to maintain weak formal institutions encourages the appearance of strong informal institutions.
Development and Biochemical Characterization of Self-Immolative Linker Containing GnRH-III-Drug Conjugates

The human gonadotropin releasing hormone (GnRH-I) and its sea lamprey analogue GnRH-III specifically bind to GnRH receptors on cancer cells and can be used as targeting moieties for targeted tumor therapy. Considering that the selective release of drugs in cancer cells is of high relevance, we were encouraged to develop cleavable, self-immolative GnRH-III-drug conjugates which consist of a p-aminobenzyloxycarbonlyl (PABC) spacer between a cathepsin B-cleavable dipeptide (Val-Ala, Val-Cit) and the classical anticancer drugs daunorubicin (Dau) and paclitaxel (PTX). Alongside these compounds, non-cleavable GnRH-III-drug conjugates were also synthesized, and all compounds were analyzed for their antiproliferative activity. The cleavable GnRH-III bioconjugates revealed a growth inhibitory effect on GnRH receptor-expressing A2780 ovarian cancer cells, while their activity was reduced on Panc-1 pancreatic cancer cells exhibiting a lower GnRH receptor level. Moreover, the antiproliferative activity of the non-cleavable counterparts was strongly reduced. Additionally, the efficient cleavage of the Val-Ala linker and the subsequent release of the drugs could be verified by lysosomal degradation studies, while radioligand binding studies ensured that the GnRH-III-drug conjugates bound to the GnRH receptor with high affinity. Our results underline the high value of GnRH-III-based homing devices and the application of cathepsin B-cleavable linker systems for the development of small molecule drug conjugates (SMDCs).
Combined isobutyryl‐CoA and multiple acyl‐CoA dehydrogenase deficiency in a boy with altered riboflavin homeostasis

In this report, we describe the case of an 11‐year‐old boy, who came to our attention for myalgia and muscle weakness, associated with inappetence and vomiting. Hypertransaminasemia was also noted, with ultrasound evidence of hepatomegaly. Biochemical investigations revealed acylcarnitine and organic acid profiles resembling those seen in MADD, that is, multiple acyl‐CoA dehydrogenase deficiencies (OMIM #231680) a rare inherited disorder of fatty acids, amino acids, and choline metabolism. The patient carried a single pathogenetic variant in the ETFDH gene (c.524G>A, p.Arg175His) and no pathogenetic variant in the riboflavin (Rf) homeostasis related genes (SLC52A1, SLC52A2, SLC52A3, SLC25A32, FLAD1). Instead, compound heterozygosity was found in the ACAD8 gene (c.512C>G, p.Ser171Cys; c.822C>A, p.Asn274Lys), coding for isobutyryl‐CoA dehydrogenase (IBD), whose pathogenic variants are associated to IBD deficiency (OMIM #611283), a rare autosomal recessive disorder of valine catabolism. The c.822C>A was never previously described in a patient. Subsequent further analyses of Rf homeostasis showed reduced levels of flavins in plasma and altered FAD‐dependent enzymatic activities in erythrocytes, as well as a significant reduction in the level of the plasma membrane Rf transporter 2 in erythrocytes. The observed Rf/flavin scarcity in this patient, possibly associated with a decreased ETF:QO efficiency might be responsible for the observed MADD‐like phenotype. The patient's clinical picture improved after supplementation of Rf, l‐carnitine, Coenzyme Q10, and also 3OH‐butyrate. This report demonstrates that, even in the absence of genetic defects in genes involved in Rf homeostasis, further targeted molecular analysis may reveal secondary and possibly treatable biochemical alterations in this pattern.
Maximal Oxygen Uptake, VO2 Max, Testing Effect on Blood Glucose Level in Adolescents with Type 1 Diabetes Mellitus

Assessing maximal oxygen uptake (VO2 max) is generally considered safe when performed properly for most adolescents; however, for adolescents with type 1 diabetes mellitus (T1DM), monitoring glucose levels before and after exercise is critical to maintaining euglycemic ranges. Limited guidance exists for glucose level recommendations for the pediatric population; therefore, the purpose of this retrospective clinical chart review study was to determine the effects of VO2 max testing on blood glucose levels for adolescents with T1DM. A total of 22 adolescents (mean age = 15.6 ± 1.8 years; male = 13, 59.1%) with a diagnosis of T1DM participated in a Bruce protocol for VO2 max from January 2019 through February 2020. A statistically significant reduction in glucose levels between pretest (<30 min, mean = 191.1 mg/dL ± 61.2) and post-test VO2 max (<5 min, mean = 166.7 mg/dL ± 57.9); t(21) = 2.3, p < 0.05) was detected. The results from this current study can help guide health and fitness professionals in formulating glycemic management strategies in preparatory activities prior to exercise testing and during exercise testing.
Letting the Struggling Saudi EFL Readers Take Lead: How Teachers Transform English Language Instruction

The paper intends to divulge and argue the major reading problems Saudi students face and flaws in contemporary research that affects a lot on developing their reading skills. The problems and pitfalls related to reading skill, prime facie, seem traditional but widely discussed; hitherto, remain unsettled in the arena of language learning. The researcher tries to explore and shed light on these problems while achieving different asymptotic levels of performance, constrained and unconstrained skills to observe and experience how far and fast the Saudi EFL learners master the reading skills in and out of classroom settings at Jazan University. It is solely based on experience and observational data that the researcher has collected on his students’ everyday classroom performance. The paper also monitors how far the previous findings contributed to overcome struggling readers’ problems and improve their reading abilities and suggests how recognizing these major occurring problems may endow with an authentic and viable initiative for planning reading instruction and interventions. Hence, the present study aims to provide in-depth examination and interpretation of struggling Saudi EFL learners’ problems and challenges meting out different texts in structure and related aspects on different reading tasks. The paper concludes with some vital suggestions that would indubitably help learners and teachers practice in realia to lessen anxiety, achieve desired outcomes and evolve educational policies for language instruction, evaluation and assessment.
How do carbon footprints from LCA and EEIOA databases compare? A comparison of ecoinvent and EXIOBASE

Life cycle assessment (LCA) and environmentally extended input output analysis (EEIOA) are two widely used approaches to assess the environmental impacts of products and services with the aim of providing decision support. Here, we compare carbon footprint (CF) results for products and services in the ecoinvent 3.4 cut‐off and the hybrid version of EXIOBASE. While we find that there is good agreement for certain sectors, more than half of the matched products differ by more than a factor 2. Best fits are observed in the energy, manufacturing, and agricultural sectors, although deviations are substantial for renewable energy. Poorer fits are observed for waste treatment and mining sectors. Both databases have a limited differentiation in the service sector. Differences can, to some degree, be explained by methodological differences, such as system boundaries and approaches used to resolve multi‐functionality, and data differences. The common finding that, due to incomplete economic coverage (truncation error), LCA‐based CFs should be lower than EEIOA‐based CFs, could not be confirmed. The comparison of CFs from LCA and EEIOA databases can provide additional insights into the uncertainties of CF results, which is important knowledge when guiding decision makers. An approach that uses the coefficient of variation to identify strategic database improvement potentials is also presented and highlights several product groups that could deserve additional attention in both databases. Further strategic database improvements are crucial to reduce uncertainties and increase the robustness of decision support that the industrial ecology community can provide for the economic transformations ahead of us. This article met the requirements for a gold‐gold JIE data openness badge described at http://jie.click/badges.
A study of prevalence, causes, risk factors and outcome of severe obstetrics haemorrhage

Severe obstetric hemorrhage is the most feared obstetric emergency that can occur to any woman at childbirth. If unattended, the hemorrhage can kill even a healthy woman. The Hemorrhage accounts for nearly one-quarter of all maternal deaths and for almost half of all postpartum deaths in low-income countries. The most common type of obstetric hemorrhage is postpartum hemorrhage (PPH), mainly primary. PPH occurring within 24 h postpartum. Primary PPH is the focus of this article. This was a cross sectional observational study conducted in a Tertiary care hospital conducted from November 2010 to June 2012 having high no of referrals from city as well as periphery. The cross tabulations were used to study the demographic, obstetrical and medical factors in women with severe obstetrical haemorrhage. Total number of patients admitted in labour room was 12,800 and 12,356 patients delivered during this period. Results showed that severe obstetrical haemorrhage (more than 1500 ml) was in 115 patients (prevalence of 0.9%). The prevalence of severe obstetric haemorrhage was 0.9 %. As 85.2% 0f the patients in study were unbooked, it contributed the high prevalence rate & antenatal care. A large proportion of the patients (62%) were multipara. Mortality in this study was 21.73% and morbidity was 78.26%. Most common cause of obstetric haemorrhage in this study was uterine atonic pph. The frequency and impact of severe hemorrhage can be effectively reduced by reducing avoidable risk factors, especially those related to obstetric interventions as increased Caesarean section rate and induction of labor. Other risk factors not amenable to change such as age, ethnic origin, and preexisting medical diseases or bleeding disorders can be minimized by extra vigilance and planned conjoined management.
Influence of coefficient of friction between punch-blank interface on formability of friction stir welded aluminum tailor welded blanks – An experimental and finite element simulation investigations

The influence of the coefficient of friction between punch-blank interface on the formability of friction stir welded aluminum tailor welded blanks was studied. Experimental and finite element investigations were performed to evaluate the formability with four different lubricants like dry lubricant, graphite in water, graphite in machine oil, and Teflon sheet (TS). During simulation, the boundary condition of the punch-blank interface was assigned as a frictional contact and the assigned value is the coefficient of friction value of the respective lubricant. To carry out the simulation, the entire blank was divided into three zones. It has been found that the coefficient of friction between punch-blank interfaces has a significant influence on formability. In the four lubrication conditions, the dry lubrication applied blank exhibited the lowest formability properties, and the TS applied blank exhibited superior formability properties in all aspects such as punch load-carrying capacity, limiting dome height, forming limit diagrams, and strain distribution profiles (experimentation and simulation). The experimental and simulation have a good agreement in all strain conditions. The standard deviation between the experimental and simulation results is ±10%.
A “Clear and Conspicuous” Distraction: Coping with Incongruent Audiovisual Content in Direct-to-Consumer Advertisements

Direct-to-consumer television advertisements for pharmaceutical medications must include a major statement disclosing the drug's most important risks and side effects. However, advertisers often pair incongruent positive visual imagery with risk information presented auditorily. Incongruence violates a principle of effective communication because it distracts from information processing. Across three studies, the authors consider how audiovisual incongruity biases perceptions of an advertised drug's risks and benefits. Using moment-to-moment measurement, Study 1 reveals that the rate of change in risk perceptions increases (i.e., accelerates) immediately after the flow of positive imagery is interrupted by a scene change during the major statement, but no such effect is observed for the advertisement in its entirety. Using post hoc measures, the latter two studies support these results. Studies 2 and 3 demonstrate that auditory risk disclosures may be enhanced by replacing distracting imagery with congruent, reinforcing text (Study 2) or by educating consumers about how distracting imagery is used as a distraction tactic (Study 3). Implications for advertising theory and recommendations for policy makers are discussed.