Miracle-dz/UniFAR-FTUs huggingface dataset:
The Role of Noncoding RNA in Airway Allergic Diseases through Regulation of T Cell Subsets

Allergic rhinitis and asthma are common airway allergic diseases, the incidence of which has increased annually in recent years. The human body is frequently exposed to allergens and environmental irritants that trigger immune and inflammatory responses, resulting in altered gene expression. Mounting evidence suggested that epigenetic alterations were strongly associated with the progression and severity of allergic diseases. Noncoding RNAs (ncRNAs) are a class of transcribed RNA molecules that cannot be translated into polypeptides and consist of three major categories, microRNAs (miRNAs), long noncoding RNAs (lncRNAs), and circular RNAs (circRNAs). Previous studies showed that ncRNAs were involved in the physiopathological mechanisms of airway allergic diseases and contributed to their occurrence and development. This article reviews the current state of understanding of the role of noncoding RNAs in airway allergic diseases, highlights the limitations of recent studies, and outlines the prospects for further research to facilitate the clinical translation of noncoding RNAs as therapeutic targets and biomarkers.
Black hole formation in the early Universe

Supermassive black holes with up to a $\rm 10^{9}~M_{\odot}$ dwell in the centers of present-day galaxies, and their presence has been confirmed at z $\geq$ 6. Their formation at such early epochs is still an enigma. Different pathways have been suggested to assemble supermassive black holes in the first billion years after the Big Bang. Direct collapse has emerged as a highly plausible scenario to form black holes as it provides seed masses of $\rm 10^{5}-10^{6}~M_{\odot}$. Gravitational collapse in atomic cooling haloes with virial temperatures T$_{vir} \geq 10^{4}$~K may lead to the formation of massive seed black holes in the presence of an intense background UV flux. Turbulence plays a central role in regulating accretion and transporting angular momentum. We present here the highest resolution cosmological large-eddy simulations to date which track the evolution of high-density regions on scales of $0.25$~AU beyond the formation of the first peak, and study the impact of subgrid-scale turbulence. The peak density reached in these simulations is $\rm 1.2 \times 10^{-8}~g~cm^{-3}$. Our findings show that while fragmentation occasionally occurs, it does not prevent the growth of a central massive object resulting from turbulent accretion and occasional mergers. The central object reaches $\rm \sim 1000~M_{\odot}$ within $4$ free-fall times, and we expect further growth up to $\rm 10^{6}~M_{\odot}$ through accretion in about 1 million years. The direct collapse model thus provides a viable pathway of forming high-mass black holes at early cosmic times.
Brain Neuroplasticity Effects on the Occurrence of Anterior Cruciate Ligament Injury and the Effect of this Injury on Brain Function and Structure: A Systematic Review

Objective: The present study aimed to investigate the effect of brain neuroplasticity on the incidence of anterior cruciate ligament (ACL) injury and on brain function and structure before and after ligament reconstruction and after a period of rehabilitation exercises. Materials & Methods: In this review study, a search was conducted in PubMed, Scopus, Web of Science, Google Scholar, ScienceDirect, MedLine, Pedro, CINAHL, SPORTDiscus, and Cochrane Databases as well as national databases on related studies published from 1970 to 2021 using keywords in Persian and English related to the research topic. Results: The initial search yielded 65 articles. Based on the inclusion and exclusion criteria, 24 articles were selected for review of which 5 articles prospectively examined the effect of brain neuroplasticity on the incidence of ACL injury. Their results showed that the brains of people with ACL injury was different from the uninjured people, especially in the motor-sensory part of the cerebral cortex and cerebellum, which caused errors during movement planning of these persons. Ten articles examined the effect of ACL injury before reconstruction on brain function and structure and reported that changes occur in the level of motor-sensory cortex of the brain at least two weeks after the injury; after one year, these structural and functional changes were widely increased in injured people compared to healthy people. These studies also showed that the ligament dysfunction and the damage to mechanical receptors cause the reorganization of the central nervous system. In injured people, the control activity of motor-visual areas and their need for visual feedback have increased. Seven articles examined these changes after ligament reconstruction and showed that the brain neuroplasticity or functional and structural changes resulting from the injury not only did not return to normal conditions, but also increased after a while despite the reconstruction. Two articles examined these changes after a period of rehabilitation exercises and showed that functional and Conclusion: The changes in the brain after ACL injury not only persist after ligament reconstruction, but also increase after reconstruction. The common rehabilitation exercises whose main focus is not on eliminating these functional and structural changes in the brain cannot overdrive this negative neuroplasticity after injury which is one of the important causes of secondary injury and subsequent complications. In developing exercises to prevent ACL injury and for rehabilitation, it is better to use the new principles of motor learning and exercises related to visual feedback along with conventional exercises to overdrive negative neuroplasticity created in the brain and create positive neuroplasticity to support ACL.
SPITZER INFRARED SPECTROGRAPH SURVEY OF YOUNG STARS IN THE CHAMAELEON I STAR-FORMING REGION

We present 5–36 μm mid-infrared spectra of 82 young stars in the ∼2 Myr old Chamaeleon I star-forming region, obtained with the Spitzer Infrared Spectrograph (IRS). We have classified these objects into various evolutionary classes based on their spectral energy distributions and the spectral features seen in the IRS spectra. We have analyzed the mid-IR spectra of Class II objects in Chamaeleon I in detail, in order to study the vertical and radial structure of the protoplanetary disks surrounding these stars. We find evidence for substantial dust settling in most protoplanetary disks in Chamaeleon I. We have identified several disks with altered radial structures in Chamaeleon I, among them transitional disk candidates which have holes or gaps in their disks. Analysis of the silicate emission features in the IRS spectra of Class II objects in Cha I shows that the dust grains in these disks have undergone significant processing (grain growth and crystallization). However, disks with radial holes/gaps appear to have relatively unprocessed grains. We further find the crystalline dust content in the inner (≲1–2 AU) and the intermediate (≲10 AU) regions of the protoplanetary disks to be tightly correlated. We also investigate the effects of accretion and stellar multiplicity on the disk structure and dust properties. Finally, we compare the observed properties of protoplanetary disks in Cha I with those in slightly younger Taurus and Ophiuchus regions and discuss the effects of disk evolution in the first 1–2 Myr.
HYDRODYNAMICAL NUMERICAL SIMULATION OF WIND PRODUCTION FROM BLACK HOLE HOT ACCRETION FLOWS AT VERY LARGE RADII

Previous works show that strong winds exist in hot accretion flows around black holes. Those works focus only on the region close to the black hole, so it is unknown whether or where the wind production stops at large radii. In this paper, we investigate this problem with hydrodynamical simulations. We take into account the gravities of both the black hole and the nuclear star clusters. For the latter, we assume that the velocity dispersion of stars is a constant and its gravitational potential ∝ &sgr; 2 ln ( r ) ? > , where σ is the velocity dispersion of stars, and r is the distance from the center of the galaxy. We focus on the region where the gravitational potential is dominated by the star cluster. We find that, just as for the accretion flow at small radii, the mass inflow rate decreases inward, and the flow is convectively unstable. However, a trajectory analysis shows that there is very little wind launched from the flow. Our result, combined with the results of Yuan et al.’s study from 2015, indicates that the mass flux of wind launched from hot accretion flow M ˙ wind = M ˙ BH ( r / 20 r s ) ? > , with r ≲ R A ≡ GM BH / &sgr; 2 ? > . Here, M ˙ BH ? > is the accretion rate at the black hole horizon, and RA is similar to the Bondi radius. We argue that the inward decrease of inflow rate is not due to mass loss via wind, but to convective motion. The disappearance of wind outside RA must be due to the change of the gravitational potential, but the exact reason remains to be probed.
Galaxy-galaxy lensing constraints on the relation between baryons and dark matter in galaxies in the Red Sequence Cluster Survey 2

We present the results of a study of weak gravitational lensing by galaxies using imaging data that were obtained as part of the second Red Sequence Cluster Survey (RCS2). In order to compare to the baryonic properties of the lenses we focus here on the ∼300 square degrees that overlap with the data release 7 (DR7) of the Sloan Digital Sky Survey (SDSS). The depth and image quality of the RCS2 enables us to significantly improve upon earlier work for luminous galaxies at z ≥ 0.3. To model the lensing signal we employ a halo model which accounts for the clustering of the lenses and distinguishes between satellite and central galaxies. Comparison with dynamical masses from the SDSS shows a good correlation with the lensing mass for early-type galaxies. The correlation is less clear for late-type galaxies, possibly due to rotation. For low luminosity (stellar mass) early-type galaxies we find a satellite fraction of ∼40% which rapidly decreases to <10% with increasing luminosity (stellar mass). The satellite fraction of the late-types has a value in the range 0‐15%, independent of luminosity or stellar mass. At high masses the satellite fraction is not well constrained, which we partly attribute to the modelling assumptions. To infer virial masses we apply simple models based on an independent satellite kinematics analysis to account for intrinsic scatter in the scaling relations. We find that early-types in the range 10 10 < Lr < 10 11.5 L� have virial masses that are about five times higher than those of late-type galaxies and that the mass scales as M200 ∝ L 2.34 +0.09 −0.16 . F or an early-type galaxy with a fiducal luminosity of 10 11 Lr,� , we obtain a mass M200 = (1.93 +0.13
Slingshot Mechanism in Orion: Kinematic Evidence For Ejection of Protostars by Filaments

By comparing 3 constituents of Orion A (gas, protostars, and pre-main-sequence stars), both morhologically and kinematically, we derive the following. The gas surface density near the integral-shaped filament (ISF) is well represented by a power law, Sigma(b)=72 Msun/pc^2(b/pc)^{-5/8} for our entire range, 0.05<b/pc<8.5, of distance from the filament ridge. Essentially all protostars lie on the ISF or other filament ridges, while almost all pre-main-sequence stars do not. Combined with the fact that protostars move <1 kms relative to the filaments while stars move several times faster, this implies that protostellar accretion is terminated by a slingshot ejection from the filaments. The ISF is the 3rd in a series of star bursts that are progressively moving south, with separations of a few Myr in time and 3 pc in space. This, combined with the filament's observed undulations (spatial and velocity), suggests that repeated propagation of transverse waves thru the filament is progressively digesting the material that formerly connected Orion A and B into stars in discrete episodes. We construct an axially symmetric gas density profile rho(r)=16 Msun/pc^3(r/pc)^{-13/8}. The model implies that the observed magnetic fields are supercritical on scales of the observed undulations, suggesting that the filament's transverse waves are magnetically induced. Because the magnetic fields are subcritical on scales of the filament on larger scales, the system as a whole is relatively stable and long lived. Protostellar ejection occurs because the gas accelerates away from the protostars, not the other way around. The model also implies that the ISF is kinematically young, which is consistent with other lines of evidence. The southern filament has a broken power law, which matches the ISF profile for 2.5<b/pc<8.5, but is shallower closer in. It is also kinematically older than the ISF.
Analisis Standarisasi Laboratorium Fisika dalam Mendukung Implementasi Kurikulum Merdeka di SMA Negeri 1 Tempel

Penelitian ini dilakukan untuk mengetahui standarisasi laboratorium fisika SMA Negeri 1 Tempel dalam mendukung implementasi kurikulum merdeka. Penelitian ini adalah penelitian deskriptif dengan menggunakan pendekatan kualitatif. Subyek yang menjadi sasaran penelitian ini adalah kepala Laboratorium, pengelola laboratorium, guru bidang studi fisika, siswa dan sarana prasarana laboratorium fisika di SMA Negeri 1 Tempel. Teknik pengumpulan data menggunakan lembar observasi, lembar angket, pedoman wawancara dan dokumentasi. Hasil penelitian standarisasi daya dukung prasarana laboratorium fisika mempunyai rerata 87,5% dengan klasifikasi sangat baik, standarisasi daya dukung sarana mempunyai rerata persentase 90,15% dengan klasifikasi sangat baik, standarisasi tenaga laboratorium mempunyai persentase 66,66% masuk kategori baik, standarisasi manajemen laboratorium fisika berdasar pada kompetensi dan sub kompetensi yang dimiliki oleh kepala laboratorium fisika mempunyai persentase 85,16% termasuk dalam klasifikasi sangat baik. Implementasi kurikulum merdeka belajar pada prinsip pembelajaran dan prinsip asesmen mempunyai kriteria baik dengan persentase 72,6%. Secara keseluruhan laboratorium fisika SMA Negeri 1 Tempel mempunyai standarisasi kategori baik, pengelola laboratorium berorientasi masa depan dengan digitalisasi informasi sehingga laboratorium fisika SMA Negeri 1 Tempel siap untuk mendukung implementasi pembelajaran kurikulum merdeka.
Higher sexual excitation is associated with an increase in sex-linked substance use in women with a history of unwanted sexual contact

Abstract:Survivors of unwanted sexual contact have an increased likelihood of using substances in sexual situations, which puts them at heightened risk for intoxication-related harms. Separately, research has indicated that women may intentionally use substances in sexual situations to either enhance pleasure (i.e., increase sexual excitation) and/or reduce sexual anxiety or shame (i.e., reduce sexual inhibition), a phenomenon termed sex-linked substance use (SLSU). A predominant assumption in the literature is that women with unwanted sex histories are more likely to disengage during sex, suggesting greater inhibition-related SLSU; however, there is little prior research directly examining if women who have unwanted sex histories primarily engage in SLSU to increase sexual excitation or decrease inhibitions. We conducted exploratory analyses of an online survey in a convenience sample of 516 undergraduate women including data on their history of unwanted sex, SLSU, and sexual excitation/inhibition. Sexual excitation mediated the association between a history of unwanted sexual contact and SLSU, suggesting that women with unwanted sexual histories reported higher levels of sexual excitation, which in turn was associated with a higher likelihood of using substances to increase pleasure during sexual activity. Specifically, arousability, partner characteristics, and power dynamics subfactors were significant mediators. Sexual inhibition did not mediate the relationship between a history of unwanted sexual contact and SLSU, suggesting that women with unwanted sex histories may have been less likely to use substances to reduce sexual inhibitions. If replicated, these findings suggest that sexual excitation may be a useful target of intervention surrounding SLSU, particularly in women with histories of unwanted sexual contact. Specifically, treatments targeting cognitive and affective tendencies associated with sexual excitation may help women who engage in SLSU to have safe, pleasurable sexual activity, without increasing the risk of intoxication-related harms.
The Impact of the COVID-19 Pandemic on eHealth Use in the Daily Practice and Life of Dutch-Speaking General Practitioners in Belgium: Qualitative Study With Semistructured Interviews

Background The COVID-19 crisis has led to rapid and far-reaching changes in digital health care, but little is known about what, why, and how changes occurred in eHealth use in Flemish general practice during the pandemic. Objective This study aims to understand how general practitioners (GPs) perceive and evaluate eHealth solutions and their eHealth experience during the COVID-19 pandemic. Methods This qualitative study was conducted using in-depth 1-on-1 semistructured interviews with the help of an interview guide. Several areas were identified beforehand to help assess the impact of the COVID-19 pandemic: perceptions of digital technologies in GP practices; changes in the use of these technologies during and after the COVID-19 pandemic; GPs’ adaptation to digitalization, benefits, risks, and challenges of eHealth; GPs motivations to change practice; and future perspectives on eHealth. In this study, purposive sampling and snowballing methods were used. Between October 2021 and April 2022, we interviewed 15 Dutch-speaking GPs in the Flemish region via the Zoom online conferencing tool. Results GPs indicated that eHealth was used more frequently during the COVID-19 pandemic than before, a change that helped them reduce their workload, enabling greater accessibility to health care services and the complementary use of digital and physical consultations. Our findings suggest that physicians underwent a significant cognitive shift in their perceptions, causing them to be more open and prepared to adopt eHealth solutions. However, there remains significant doubt and uncertainty about digital literacy for certain groups, privacy, data security, reimbursement, and the burden of technical information and communication technologies (ICT) issues. Conclusions The COVID-19 pandemic seems to have been a turning point for eHealth by Flemish GPs. eHealth is an essential complementary health care service that can reduce pressure on health care as well as increase health care accessibility. Sensitive aspects, such as privacy, data security, digital literacy, reimbursement, and the burden of technical ICT issues, are particularly emphasized. With our results, we can offer recommendations to health IT policymakers and developers that will help maintain the continuity of eHealth solutions beyond the COVID-19 pandemic, considering the expectations and sensitivities presented in the study.
Quantum key distribution without sending a quantum signal

Quantum Key Distribution is a quantum communication technique in which random numbers are encoded on quantum systems, usually photons, and sent from one party, Alice, to another, Bob. Using the data sent via the quantum signals, supplemented by classical communication, it is possible for Alice and Bob to share an unconditionally secure secret key. This is not possible if only classical signals are sent. While this last statement is a long standing result from quantum information theory it turns out only to be true in a non-relativistic setting. If relativistic quantum field theory is considered we show it is possible to distribute an unconditionally secure secret key without sending a quantum signal, instead harnessing the intrinsic entanglement between different regions of space–time. The protocol is practical in free space given horizon technology and might be testable in principle in the near term using microwave technology.
Effects of transcranial direct current stimulation (tDCS) on pro-inflammatory cytokines: a systematic review

Transcranial direct current stimulation (tDCS) is a neuromodulation technique that causes alterations in the synthesis of several proteins, including cytokines (e.g., Interleukins). Pro-inflammatory cytokines are associated with the presence of pain and their reduction occurs in several pathologies. The aim of this study was to investigate the effects of tDCS on the variation of tissue and serum blood levels of pro-inflammatory cytokines and its relationship with behavioral changes, through a systematic review. PubMed, Embase and Lilacs database searches were performed for articles published in all languages ​​before October 1, 2020. The search was based on the keywords "Transcranial Direct Current Stimulation" or "tDCS" and "IL-1alpha " or "IL-1Beta" or "IL-6" or "IL-8" or "IL-17" or "Tumoral necrosis factor alpha" or "TNF-alpha". The systematic review protocol was registered in PROSPERO (CRD42021283417). Initially, 416 studies were identified in the electronic databases, of which 40 were eliminated because they were duplicates. Of the remaining 376, 358 were excluded after analyzing the title and abstract (selection stage) and 09 were excluded after a complete reading. Nine studies were considered for evaluation. The results demonstrate that tDCS can alter the levels of pro-inflammatory cytokines and modify behaviors in animals, however these findings are variable. Still, the cause and effect relationship between cytokine levels and behavioral changes found was not conclusive. Further studies are needed to establish the mechanisms involved in the action of tDCS on the levels of pro-inflammatory cytokines.
Economic complexity and environmental degradation: Evidence from OECD countries

We augment the existing knowledge on the role of economic complexity in the environment and sustainable development debate by examining the effect of economic complexity on environmental degradation (measured by ecological footprint, CO 2 emissions, N 2 O emissions and greenhouse gas emissions) contingent on income, using data from 35 OECD countries between 1998 and 2017. With the fixed effects model estimator, we find that income facilitates economic complexity to mitigate ecological footprint, CO 2 emissions, N 2 O emissions and greenhouse gas emissions. Also, we fit a partial linear functional-coefficient model to find that income influences economic complexity to exert a nonlinear effect on ecological footprint, CO 2 emissions, N 2 O emissions and greenhouse gas emissions. We find that economic complexity leads to an increase in ecological footprint, CO 2 emissions, N 2 O emissions and greenhouse gas emissions at lower income levels but gradually dampens them as income rises. Finally, by applying the Method of Moments Quantile regression to control for distributional heterogeneity, we also find that the mitigating effect of economic complexity on ecological footprint, CO 2 emissions, N 2 O emissions and greenhouse gas emissions is transmitted through income across quantiles. The policy implications are discussed.
Identifying Ultimate Controlling Shareholders In Indonesian Public Companies: an Empirical Survey

This paper aims to identify the ultimate ownership of public companies that are listed on the Indonesia Stock Exchange (IDX) during 2014-2017 period. Identification techniques used in this study are: (1) tracking the ownership structure; (2) measuring the level of control; (3) determining the majority ownership, and (4) finding the ‘controlling shareholder’ narrative in the annual report. Based on tim research analyze, this paper found that the ultimate ownership of public companies in Indonesia 2014-2017 was concentrated in the ultimate family owners (54.43%), corporations (31.05%) and the state (7.49%). Beside it, 89.43% of families use the indirect ownership structure (pyramid ownership). In addition, more than 50% of the ultimate family ownership place their family members in the Board of Commissioner (BOC) and Board of Directors (BOD).