Miracle-dz/UniFAR-FTUs huggingface dataset:
Measuring Lethal Force Performance in the Lab: The Effects of Simulator Realism and Participant Experience

Objective The goal of the current study was to compare two types of shooting simulators to determine which is best suited for assessing different aspects of lethal force performance. Background Military and law enforcement personnel are often required to make decisions regarding the use of lethal force. A critical goal of both training and research endeavors surrounding lethal force is to find ways to simulate lethal force encounters to better understand behavior in those scenarios. Method Participants of varying degrees of experience completed both marksmanship and shoot/don’t shoot scenarios on both a video game and a military-grade shooting simulator. Using signal detection theory, we assessed sensitivity as a measure of lethal force performance overall. We used hit rate to assess shooting accuracy and false alarm rate to assess decision making. Results Results demonstrated that performance was correlated across simulators. Results supported the notion that shooting accuracy and decision making are independent components of performance. Individuals with firearms expertise outperformed novices on the military-grade simulator, but only with respect to shooting accuracy, not unintended casualties. Individuals with video game experience outperformed novices in the video game simulator, but again only on shooting accuracy. Conclusion Experience played a crucial role in the assessment of shooting accuracy on a given simulator platform; decision-making performance remained unaffected by experience level or type of simulator. Application We recommend that in expert populations or when assessing shooting accuracy, a military-grade shooting simulator be used. However, with a novice population and/or when interested in decision making in lethal force, a video game simulator is appropriate.
Dental Care for Asylum-Seekers in Germany: A Retrospective Hospital-Based Study

Background: The growing immigration to Germany led to more patients whose medical needs are divergent from those of the domestic population. In the field of dental health care there is a debate about how well the German health system is able to meet the resulting challenges. Data on asylum-seekers’ dental health is scarce. This work is intended to reduce this data gap. Methods: We conducted this retrospective observational study in Halle (Saale), Germany. We included all persons who were registered with the social welfare office (SWO) in 2015 and received dental treatments. From the medical records, we derived information such as complaints, diagnoses, and treatments. Results: Out of 4107 asylum-seekers, the SWO received a bill for 568 people. On average, there were 1.44 treatment cases (95%-CI: 1.34–1.55) and 2.53 contacts with the dentist per patient (95%-CI: 2.33–2.74). Among those, the majority went to the dentist because of localized (43.2%, 95%-CI: 38.7–47.7) and non-localized pain (32.0%, 95%-CI: 27.8–36.2). The most widespread diagnosis was caries (n = 469, 98.7%, 95%-CI: 97.7–99.7). Conclusion: The utilization of dental care is lower among asylum-seekers than among regularly insured patients. We assume that the low prevalence rates in our data indicate existing access barriers to the German health care system.
The Effect of Sacubitril/Valsartan on Device Detected Arrhythmias and Electrical Parameters among Dilated Cardiomyopathy Patients with Reduced Ejection Fraction and Implantable Cardioverter Defibrillator

Sacubitril/valsartan therapy reduces sudden cardiac death (SCD) among patients with reduced ejection fraction (HFrEF) when compared to guidelines recommended doses of enalapril, however the mechanism is still not clear. There are few, contrasting results about the effect of sacubitril/valsartan on arrhythmias in the clinical context of dilated cardiomyopathy (DCM) and there are no clinical data about its effect on measured implantable cardioverter defibrillator (ICD) electrical parameters, such as atrial/ventricular electrograms sensing and pacing threshold. We conducted a 12 month follow-up observational study in 167 ischemic and nonischemic DCM patients (mean age 68.1 ± 11.6 years; 85% male), with dual-chamber ICD on sacubitril/valsartan treatment, to evaluate the incidence of device detected tachyarrhythmia events, both atrial and ventricular, and the change in measured ICD electrical parameters. We collected data on clinical, electrocardiographic and echocardiographic parameters to find a possible electro-mechanical correlation within results. Our results show that DCM patients with reduced ejection fraction and ICD on sacubitril/valsartan treatment experienced a reduction in both atrial and ventricular arrhythmias incidence and an improvement in ICD electrical atrial parameters. The findings might be explained by the electro-mechanical cardiac reverse remodeling induced by sacubitril/valsartan therapy.
Sensory Characteristics and Volatile Compounds of Herbal Teas and Mixtures of Bush Tea with Other Selected Herbal Teas of South Africa

South Africa has a traditional heritage of using indigenous herbal teas, and the demand for herbal teas motivated by the functional health benefits has far exceeded global supply. This has led to worldwide interest in the sensory characteristics and volatile compound characterisation of herbal drink formulations. The objective of this study was to investigate the descriptive sensory analysis and volatile compounds of bush, special, honeybush and rooibos tea and the blend of bush tea with special, honeybush and rooibos, respectively. The trained sensory panel scored each tea sample for aroma, taste, aftertaste and mouthfeel attributes using sensory evaluation practices. Compound identification was performed by gas chromatography connected to a mass spectrometer (GC-MS). The results of the study demonstrated that rooibos and honeybush tea had an overall sweet-caramel, honey-sweet, perfume floral and woody aroma while bush tea and special tea depicted green-cut grass, dry green herbal and astringent/dry mouth feel. The GC-MS analyses depicted the following compounds 2-furanmethanol, 2-methoxy-4-vinylphenol, D-limonene, dihydroactinidolide, linalool, (E,E)-2,4-heptadienal, and phytol. The blending of bush tea with rooibos and honeybush tea toned down its astringent mouth feel. Compounds identified in this study may be useful markers for potential herbal tea sensory characteristics.
Occurrence of Sweetpotato (Ipomoea batatas) Wilt and Surface Rot Disease and Determining Resistance of Selected Varieties to the Pathogen in Korea

Fusarium wilt and Fusarium surface rot caused by Fusarium oxysporum Schltdl are the major diseases of sweetpotato (Ipomoea batatas) and was surveyed in different locations (Cheongju, Heanam, Iksan, Icheon, Kimje, Nonsan, Yeoungam, and Yeoju) in Korea from 2015 to 2017 in the field, after harvesting and in storehouse. The wilt incidence in the early stage represented 17.9%, 5.9%, and 8.3% in 2015, 2016, and 2017, respectively. Samples were collected, and the causal organism was isolated on potato dextrose agar (PDA). Ten pure cultures were stored at the Sweetpotato Research Laboratory, Bioenergy Crop Research Institute, Muan, Korea. Morphological analysis, along with molecular phylogeny of the sequences of internal-transcribed spacer (ITS) and elongation factor 1-α (EF-1α) genes and their combined phylogenetic analysis, confirmed the isolates as the Fusarium oxysporum Schltdl. Pathogenicity tests were conducted on sweetpotato stems, and storage roots by artificially inoculation methods, and the most virulent isolate was selected as SPL18019. A rapid screening method on 21 selected varieties for resistant variety selection was applied on stems. The Pungwanmi was found resistant to Fusarium wilt, whereas Annobeni was the most susceptible. On the other hand, six varieties were used to test surface rot resistance, and Yulmi and Yesumi were resistant and susceptible, respectively, to Fusarium surface rot.
Hypertension and its associated factors among current drinkers in Malaysia: Results from the National Health and Morbidity Survey 2015

ABSTRACT Objectives: This study was carried out to determine the proportion of hypertension and its associated factors among current drinkers in Malaysia. Methodology: The data were obtained from the National Health and Morbidity Survey 2015, a cross-sectional population survey design with two-stage stratified random sampling method which involved Malaysian adults above 18 years. Data on alcohol consumption were obtained through a validated self-administered Alcohol Use Disorder Identification Test questionnaire. A complex sampling analysis and multiple logistic regression analysis were applied. Results: A total of 1065 adults (8.4%; 95% confidence interval: 7.4–9.5) were categorized as current drinkers. Among the current drinkers, 28.4% were identified as having a risky drinking pattern and a fourth (26.6%) of them had hypertension. The multivariable model shows that hypertension risk among current drinkers was significantly higher in male (adjusted odd ratio [AOR] 2.05), with increasing age (AOR 1.06), with risky drinking pattern (AOR 1.44), in current drinkers with diabetes (AOR 2.56) and in overweight (AOR 3.54). Conclusions: The proportion of current drinker having hypertension was alarming and become deleterious, especially among men, increase of age, risky drinker and those with other non-communicable disease co-morbidities. Preventive counselling for alcohol use among them should be integrated into primary care.
Clinical Value of lncRNA MEG3 in High-Grade Serous Ovarian Cancer

Long non-coding RNAs (lncRNAs) are emerging as regulators in cancer development and progression, and aberrant lncRNA profiles have been reported in several cancers. Here, we evaluated the potential of using the maternally expressed gene 3 (MEG3) tissue level as a prognostic marker in high-grade serous ovarian cancer (HGSOC), the most common and deadliest gynecologic malignancy. To the aim of the study, we measured MEG3 transcript levels in 90 pre-treatment peritoneal biopsies. We also investigated MEG3 function in ovarian cancer biology. We found that high MEG3 expression was independently associated with better progression-free (p = 0.002) and overall survival (p = 0.01). In vitro and in vivo preclinical studies supported a role for MEG3 as a tumor suppressor in HGSOC, possibly through modulation of the phosphatase and tensin homologue (PTEN) network. Overall, results from this study demonstrated that decreased MEG3 is a hallmark for malignancy and tumor progression in HGSOC.
High Physical Self-Concept Benefits on School Adjustment of Korean Student-Athletes

Successful adjustment of student-athletes to their school is an internationally relevant issue. In Korea, school-athletes abandon their athletic activity at a rate of over 40%, suggesting an urgent need to develop measures that allow them to balance sports and academic life. Therefore, this study aimed to investigate the effect of physical self-concept on school adaptation among student-athletes. We analyzed data from 589 student-athletes, including sex and award-winning career as covariates. Then, reliability and validity of scales were obtained. The results showed that student-athletes with higher physical self-concept are more likely to be successful in school adjustment. The effects of physical self-concept on school adjustment were proven to be mediated by sex and award-winning career of student-athletes. This result provides the basis for the importance of recognizing the concept of physical self as a way for student athletes to adapt well to school life. As differences depending on gender and award experience exist, they should be taken into account when teaching student athletes.
Decreased serum zinc concentration in dogs with lymphocytic-plasmacytic enteritis, and its associations with disease severity and prognosis

Human patients with inflammatory bowel disease may have poor prognosis with hypozincemia. However, there are limited data on zinc concentrations in the blood of dogs with lymphocytic-plasmacytic enteritis (LPE). The purpose of this study was to investigate the serum zinc concentration in dogs with LPE and its influence on disease severity and prognosis. Thirty-five dogs with LPE were recruited. Serum zinc concentration was measured using atomic absorption spectrometry. Hypozincemia was observed in 18/35 (51%) dogs with LPE. Serum zinc concentration was inversely correlated with histological and clinical severities. Overall survivals were significantly shorter in dogs with hypozincemia than in those without it. These findings suggest that serum zinc concentration is a useful biomarker for LPE severity and prognosis in dogs.
Propofol Modulates Early Memory Consolidation in Humans

Abstract Maintenance of memory across time is crucial for adaptive behavior. Current theories posit that the underlying consolidation process depends on stabilization of synapses and reorganization of interactions between hippocampus and neocortex. However, the temporal properties of hippocampal-neocortical network reconfiguration during consolidation are still a matter of debate. Translational research on this issue is challenged by the paucity of techniques to transiently interfere with memory in the healthy human brain. Here, we report a neuro-pharmacological approach with the GABAAergic anesthetic propofol and a memory task sensitive to hippocampal dysfunction. Patients undergoing minor surgery learned word lists before injection of an anesthetic dose of propofol. Results show that administration of the drug shortly after learning (∼13 min) impairs recall after awakening but spares recognition. By contrast, later administration (∼105 min) has no effect. These findings suggest significant changes in memory networks very early after learning that are decisive for later recall. Propofol general anesthesia provides an experimental tool to modulate the first steps of hippocampus-mediated memory consolidation in humans.
Clinical factors associated with baseline history of atrial fibrillation and subsequent clinical outcomes following initial implantable cardioverter‐defibrillator placement

Atrial fibrillation (AF) is frequently present in patients with heart failure (HF) and an implantable cardioverter‐defibrillator (ICD). This study aims to identify clinical factors associated with a baseline history of AF in ICD recipients, and compares subsequent clinical outcomes in those with and without a baseline history of AF.
Clinical impact of strain histogram EUS elastography and contrast-enhanced EUS for the differential diagnosis of focal pancreatic masses: A prospective multicentric study

Background: Recent advances in EUS techniques (real-time EUS elastography and contrast-enhanced EUS) have allowed a better characterization of focal pancreatic masses. Mean strain histograms (SHs) are considered a good parameter for the semi-quantitative evaluation of focal pancreatic masses, alongside complementary contrast-enhanced EUS parameters which can be quantified during both the early arterial and late venous phase. Materials and Methods: The study design was prospective, blinded, and multicentric, assessing real-time EUS elastography and contrast-enhanced EUS results for the characterization of focal pancreatic masses using parametric measurements, in comparison with pathology which is the gold standard. SHs were performed based on the embedded software of the ultrasound system, with the values being reversed as opposed to our initially published data on hue histograms. Consequently, a cutoff of 80 was derived from previous multicentric trials. Contrast-enhanced EUS also allowed the focal masses to be classified as hyper-, iso-, or hypoenhanced in comparison with the normal pancreatic parenchyma. EUS-FNA was then performed for all patients, with a positive cytological diagnosis taken as a final proof of malignancy for the pancreatic masses. The diagnoses obtained by EUS-FNA were verified further either by surgery or during a clinical follow-up of at least 6 months. Results: A total number of 97 consecutive patients with focal pancreatic masses were included in the study. Based on previously defined cutoffs of 80, the values of sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of the mean SHs for the diagnosis of pancreatic cancer were 100%, 29.63%, 78.65%, 100%, and 80.41%, respectively. Corresponding values for contrast-enhanced EUS (taking into consideration hypoenhencement as a predictive factor of malignancy) were 98.57%, 77.78%, 92%, 95.45%, and 92.78%, respectively. Combining contrast enhancement-EUS (hypoenhencement) and semi-quantitative EUS elastography (SH cutoffs <80), the resulting values corresponding for sensitivity, specificity, and accuracy were 98.57%, 81.48%, and 93.81%, respectively. Conclusion: The current study using objective parametric tools for both EUS elastography and contrast-enhanced EUS confirmed the results of previous studies and meta-analyses that indicated a complementary role for the differential diagnosis of focal pancreatic masses. Moreover, the best values for the receiver operating curves were obtained using a sequential clinical algorithm based on the initial use of elastography, followed by contrast enhancement.
Dysmenorrhoea among students aged 18–45 years attending University in Uganda: A cross‐sectional multicenter study of three Universities in Uganda

Dysmenorrhoea presents as pain associated with menstruation. It is often an issue discussed privately, yet it continues to affect girls and women with grave impact on their education, social activities and work. This study sought to assess the factors associated with dysmenorrhoea among female students aged 18–45 years in three selected universities in Kampala Capital city, Uganda.
Casualty risk of e-bike rider struck by passenger vehicle using China in-depth accident data

Abstract Objective: Traffic deaths involving e-bike (electric bike) riders are increasing in China. This study aims to quantitatively investigate the association between e-bike rider casualty and impact speed in electric bike-passenger vehicle collisions based on China in-depth accident study data. Methods: According to the collision location and driving direction of the e-bike and the vehicle, electric bike-passenger vehicle collisions are divided into five collision types: frontal collision, e-bike side collision, vehicle side collision, scrape collision and rear-end collision. Since e-bike side collision (the side of e-bike impacted with the front of vehicle) is the leading type and has the highest likelihood of severe or fatal injury in all collision types, e-bike side collisions are further selected to build the casualty risk functions of e-bike rider in relation to the rider age and the impact speed (vehicle impact speed and e-bike impact speed). Results: The analysis results show that, as for e-bike side collisions and e-bike impact speed is 20 km/h, the fatality risk of riders is approximately 2.9% at vehicle impact speed of 30 km/h, 23% at 50 km/h, 50% at 60 km/h, and 90% at 80 km/h. Rider age is also significantly associated with a higher risk of severe and fatality injury. The e-bike impact speed is not significantly associated with the severe and fatality risk in e-bike side collisions. Conclusions: The findings of this study provide meaningful insights to formulate effective policies especially for speed limit management to improve the safety of e-bikes.
Social Networking Site Usage and Its’ Impact on Depressive Symptoms among Older Men and Women in South Korea

Background: We examined the rate of social networking site (SNS) usage and the relationship between SNS usage and depressive symptoms among older men and women in South Korea. Methods: The data were obtained from the Living Profiles of Older People Survey (LPOPS), which comprises a nationally representative sample of non-institutionalized Korean older adults living in the community. A total of 10,073 older persons (4286 men and 5787 women) were included in the analysis. Results: A total of 26.0% of the total study population reported to use social network sites. Of the men and women, 32.6 and 21.1%, respectively, used SNS. A higher educational level and higher equivalent household income, lower number of chronic illnesses, no limitation in daily activities, living with others, and having good relationships with friends and neighbors were associated with higher SNS usage among older men and women. SNS usage was significantly associated with reduced depression scores in older men, but not in women. Conclusions: The difference in SNS usage between older men and women might be partially explained by differential exposure to digital technologies and disadvantages in education and economic opportunities. Education programs for digitalization and opportunities to engage with technology need to be provided.
Taxonomy and diversity of Epichloë endophytes.

Epichloe is one of seven genera recognized within the tribe Balansieae of the Clavicipitaceae, which represent exclusively systemic biotrophs of graminoid hosts (Diehl, 1950; White, 1994b; White and Reddy, 1998; White et al., 2000). Other members of the family are either not systemic and perennial (tribes Clavicipeae, Ustilaginoideae) or are pathogens of invertebrates or other fungi (tribe Cordycipeae). A key feature of Epichloe is the endophytic lifestyle, which includes intercellular colonization of host tissues and frequent seed transmission. Most species of other balansiean genera (e.g., Atkinsonella, Balansia, Myriogenospora, Parepichloe) live epibiotically on host meristems and surfaces of leafs or culms. Epichloe species form light-colored, external reproductive structures, the stromata, which envelope inflorescences and the upper leaf sheaths of flowering culms (choke disease). The anamorphic state which is formed on the surface of the young stromata is classified in Neotyphodium (Glenn et al., 1996). Its one-celled conidia, typically ovoid to navicular in shape, are borne from simple phialids.
Recognizing the unique prenatal phenotype of Prader‐Willi Syndrome (PWS) indicates the need for a diagnostic methylation test

Prader‐Willi syndrome (PWS) is a neurogenetic disorder characterized by mental retardation, morbid obesity, and endocrine and behavior disorders. We previously showed in a small group of patients that PWS may have a unique prenatal phenotype. We aimed to characterize clinical and ultrasonic features in a larger series of pregnancies with a PWS fetus.