Miracle-dz/UniFAR-FTUs huggingface dataset:
COVID‐19 infection in patients with haematological malignancies: A single‐centre survey in the latest Omicron wave in China

As the COVID‐19 variant Omicron surge in Beijing, China, a better understanding of risk factors for adverse outcomes may improve clinical management in patients with haematological malignancies (HM) diagnosed with COVID‐19. The study sample includes 412 cases, mainly represented by acute leukaemia, chronic myeloid leukaemia (CML), plasma cell disorders and lymphoma and chronic lymphocytic leukaemia. COVID‐19 pneumonia was observed in 10.4% (43/412) of patients, and severe/critical illness was observed in 5.3% (22/412). Among the 86 cases with advanced malignancies, 17.6% (12/86) of patients developed severe/critical COVID‐19, which was significantly higher than reported in patients with stable malignancies (9/326, 2.70%, p < 0.001). Similarly, the advanced malignancy cohort had a higher mortality rate (9/86, 10.5% vs. 0/326, 0%, p < 0.001) and a poor 30‐day overall survival (OS) compared with the stable malignancy cohort (74.2% vs. 100.0%, p < 0.0001). Overall, nine patients (2.2%) died. The primary cause of death was progressive HM in four patients and a combination of both COVID‐19 and HM in five patients. In the multivariable analysis, over 65 years of age, comorbidities and advanced malignancy were correlated with severe/critical COVID‐19 in HM patients. This study sheds light on the poor outcomes among COVID‐19 HM patients with the leading cause of advanced malignancy.
Clinical and immunological features in children with multisystem inflammatory syndrome associated with SARS-CoV-2

Background and aim of the research: MIS-C is characterized by intense immune activation and increased production of cytokines. The aim of our study was to analyze the changes of cellular and humoral immune responses in children with MIS-C, depending on the severity of the disease. Methods: Clinical, hematological and immunological parameters in children with severe and extremely severe MIS-C were compared. The study included a total of 50 patients divided into 3 groups: 20 children with extremely severe MIS-C requiring ICU care (MIS-C ICU “+”); 15 children with severe MIS-C but not requiring ICU care (MIS-C ICU “-”); and a control group of 15 children who had previously had COVID-19 and didn’t have MIS-C (MIS-C “-”). Results: In patients with MIS-C requiring ICU care, heart and liver damage, hematological changes, and the development of severe complications such as edematous syndrome, polyserositis, DIC, and cardiogenic shock were statistically more common. Both groups of children with MIS-C had CD3+ T-cell lymphopenia and a decrease in CD95 expression. In the group of children with MIS-C requiring ICU care, a significant increase in the relative numbers of B-lymphocytes, CD3-HLA-DR+ and CD25 and a decrease of NK-cells was observed. Conclusions: Conditions requiring ICU care in children with MIS-C are associated with a more profound immune dysregulation, as evidenced by our data. (www.actabiomedica.it)
Tumor loss-of-function mutations in STK11/LKB1 induce cachexia

Cancer cachexia (CC), a wasting syndrome of muscle and adipose tissue resulting in weight loss, is observed in 50% of patients with solid tumors. Management of CC is limited by the absence of biomarkers and knowledge of molecules that drive its phenotype. To identify such molecules, we injected 54 human non–small cell lung cancer (NSCLC) lines into immunodeficient mice, 17 of which produced an unambiguous phenotype of cachexia or non-cachexia. Whole-exome sequencing revealed that 8 of 10 cachexia lines, but none of the non-cachexia lines, possessed mutations in serine/threonine kinase 11 (STK11/LKB1), a regulator of nutrient sensor AMPK. Silencing of STK11/LKB1 in human NSCLC and murine colorectal carcinoma lines conferred a cachexia phenotype after cell transplantation into immunodeficient (human NSCLC) and immunocompetent (murine colorectal carcinoma) models. This host wasting was associated with an alteration in the immune cell repertoire of the tumor microenvironments that led to increases in local mRNA expression and serum levels of CC-associated cytokines. Mutational analysis of circulating tumor DNA from patients with NSCLC identified 89% concordance between STK11/LKB1 mutations and weight loss at cancer diagnosis. The current data provide evidence that tumor STK11/LKB1 loss of function is a driver of CC, simultaneously serving as a genetic biomarker for this wasting syndrome.
The Effect of Probiotics on Headaches in Children with Migraine Treated with Sodium Valproate: A Randomized Controlled Clinical Trial

Objective Migraine is one of the most common complaints in children. This study aimed to determine the effect of probiotics (KidiLact) on headaches in children aged six to 15 years with migraine treated with sodium valproate. Materials & Methods This double-blind, randomized controlled clinical trial was performed on eighty children with migraine treated with sodium valproate. Patients were divided into two groups. All patients in the intervention and control groups received two sachets of probiotics and a placebo daily for four months, respectively. They were compared in terms of frequency and severity of headaches and painkiller consumption before and two and four months after initiating probiotics. Results The mean number of headaches in the second and third visits in the probiotic group was 1.27 and 1.18, and 2 and 1.50 per month in the placebo group, respectively. The authors observed a significant difference between the two groups in the second (P = 0.010) and the third visit (P = 0.019). Moreover, the mean severity of headache in the second and third visits in the probiotic group was 1.38 and 1.23, and 1.60 and 1.53 in the placebo group, respectively. The authors demonstrated that the daily consumption of painkillers in the probiotic group was significantly reduced compared to the placebo group (P = 0.007). Conclusion Using probiotic supplements seems to significantly affect the severity and frequency of migraine headaches compared to the placebo, and daily consumption of painkillers was significantly reduced in the probiotic group compared to the placebo group.
Patient‐controlled intravenous administration of dexmedetomidine with nalbuphine versus sufentanil for post cesarean delivery analgesia: A retrospective observational study

This retrospective observational study aims to investigate the patient‐controlled intravenous analgesia (PCIA) of dexmedetomidine (DEX) with nalbuphine (NAL) versus sufentanil (SUF) for post‐cesarean delivery management. A total of 300 women were evaluated who underwent cesarean section surgery with combined spinal‐epidural anesthesia. After surgery, all patients were connected to a patient‐controlled analgesia pump. The PCIA protocol was programmed with 0.11 μg/kg/h DEX in combination with 0.03 μg/kg/h SUF in Group I (n = 150) or 0.11 μg/kg/h DEX in combination with 0.03 mg/kg/h NAL in Group II (n = 150). There was no significant difference in incision pain and sedation level between the two groups within 48 h after the surgery assessed by visual analog scale (VAS) and Ramsay sedation scale, respectively. However, at 2, 6, 12, and 24 h after surgery, visceral pain at rest and at mobilization was alleviated in the Group II as compared with the Group I with lower VAS scores. Moreover, fewer adverse reactions were found in the Group II when compared with Group I, including postpartum respiratory depression, nausea/vomiting, urinary retention, and cardiovascular events. Overall, there was an increased patient satisfaction in the Group II as compared with the Group I. Based on the results of this study, it seems that adding NAL to PCIA with DEX, as compared to SUF with DEX, have an effect on reducing the intensity of visceral pain after cesarean section with less adverse reactions and higher patient satisfaction.
Diagnosis, Treatment and Follow-Up of Sinonasal Leiomyomas: A Systematic Review

Background Leiomyomas are benign smooth muscle tumors that are rarely diagnosed in the nasal cavity and paranasal sinuses. Objective This systematic review summarizes the histopathologic and clinical tumor characteristics, surgical management, and follow-up of sinonasal leiomyomas. Methods A systematic review of the literature on sinonasal leiomyoma was performed by applying the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. Studies that met the inclusion criteria were assessed for level of evidence. Patient demographics, clinical and pathological tumor characteristics, primary intervention, and results of follow-up were evaluated. Results Forty studies including 84 patients with sinonasal leiomyoma were identified. The tumor was most often located in the nasal cavity (47/84, 56%) originating from the inferior turbinate (32/84, 38%). Patients mostly presented with symptoms originating from an intranasal mass, including recurrent epistaxis (41/84, 49%), nasal obstruction (43/84, 51.2%), and localized facial or head pain (25/84, 29.8%). Surgery was performed in all cases. An endoscopic approach was most frequently chosen. Recurrence occurred only twice (2.4%). Morbidity was noted in 2 cases (2.4%) following postoperative bleeding and 1 (1.2%) case following a CSF leak. Conclusion Sinonasal leiomyomas are neoplasms of the smooth muscle manifesting clinically with recurrent epistaxis and nasal obstruction. Management goal is total resection with clear margins to avoid local recurrence.
LUTE ERROR DOES NOT TREAT EXAMPLES EQUALLY

In this work, we study robust deep learning against abnormal training data from the perspective of example weighting built in empirical loss functions, i.e., gradient magnitude with respect to logits, an angle that is not thoroughly studied so far. Consequently, we have two key findings: (1) Mean Absolute Error (MAE) Does Not Treat Examples Equally. We present new observations and insightful analysis about MAE, which is theoretically proved to be noise-robust. First, we reveal its underfitting problem in practice. Second, we analyse that MAE’s noise-robustness is from emphasising on uncertain examples instead of treating training samples equally, as claimed in prior work. (2) The Variance of Gradient Magnitude Matters. We propose an effective and simple solution to enhance MAE’s fitting ability while preserving its noise-robustness. Without changing MAE’s overall weighting scheme, i.e., what examples get higher weights, we simply change its weighting variance non-linearly so that the impact ratio between two examples are adjusted. Our solution is termed Improved MAE (IMAE). We prove IMAE’s effectiveness using extensive experiments: image classification under clean labels, synthetic label noise, and real-world unknown noise.
Equilibrium shapes of liquid drops on pre-stretched nonlinear elastic membranes

Abstract We investigate the equilibrium of an axisymmetric system consisting of sessile and pendent drops on pre-stretched nonlinear elastic membranes. The membrane experiences large deformations due to the drop's weight and interfacial interactions. We first show that force balance alone leads to non-unique equilibrium solutions. Identifying the system's equilibrium with the minimum of its free energy, we then demonstrate that the equilibrium solution is made unique by requiring the continuity of meridional stretches across the three-phase contact circle. For a special class of nonlinear elastic materials – $I_2$ materials – we then compute the equilibrium configurations of the drop–membrane system for a range of drop volumes and membrane pre-tensions. Finally, the present work facilitates two important applications: (a) the membrane's pre-tension and current tension are related exactly to help in utilizing the system as an elastocapillary probe for membrane pre-tension and (b) we suggest an experimental protocol for measuring the membrane's surface properties.
Ecology and distribution of the “Critically Endangered” Blue-throated Hillstar Oreotrochilus cyanolaemus

Summary The Blue-throated Hillstar Oreotrochilus cyanolaemus is a recently described hummingbird endemic to the southern Andes of Ecuador. This “Critically Endangered” species faces multiple conservation problems; thus, acquiring basic ecological information is a key step for guiding sound and integral conservation actions. We performed a series of expeditions throughout the cordillera Chilla-Tioloma-Fierro Urco to gain new data about its ecology, abundance, breeding, and distribution. From November 2019 to March 2020, we surveyed a total of 161.6 km searching for O. cyanolaemus, and gathered data on encounter rates, microhabitats used, and flower resources used. From November 2020 to January 2021 we studied the breeding ecology of the species. Occurrence records of O. cyanolaemus were used to build a species distribution model, based on climatic variables and the normalised difference vegetation index (NDVI). We found that the species is relatively more abundant in the western and central portion of its distribution range. Males were found using more shrubby habitats than females, who used more open habitats. They visited flowers of 11 plant species, with Chuquiraga jussieui and Puya ssp. being the most frequently used flowers. Nests were found in caves and rocky walls, and only one out of three active nests was successful. The distribution model indicated that the species has a potential distribution range of 62.7 km2. This manuscript is the first comprehensive evaluation of the ecological requirements of the species, and the information provided has important potential for use as a conservation guide for the species and its habitats.
A precise measurement of the top quark mass in dilepton final states using 9.7 fb$^{-1}$ of D{\O} Run II data

The top quark is a very special fundamental particle in the Standard Model (SM) mainly due to its heavy mass. The top quark has extremely short lifetime and decays before hadronization. This reduces the complexity for the measurement of its mass. The top quark couples very strongly to the Higgs boson since the fermion-Higgs Yukawa coupling linearly depends on the fermion’s mass. Therefore, the top quark is also heavily involved in Higgs production and related study. A precise measurement of the top quark mass is very important, as it allows for self-consistency check of the SM, and also gives a insight about the stability of our universe in the SM context. This dissertation presents my work on the measurement of the top quark mass in dilepton final states of t$$\bar{t}$$ events in p$$\bar{p}$$ collisions at √s = 1.96 TeV, using the full DO Run II data corresponding to an integrated luminosity of 9.7 fb-1 at the Fermilab Tevatron. I extracted the top quark mass by reconstructing event kinematics, and integrating over expected neutrino rapidity distributions to obtain solutions over a scanned range of top quark mass hypotheses. The analysis features a comprehensive optimization that I made to minimize the expected statistical uncertainty. I also improve the calibration of jets in dilepton events by using the calibration determined in t$$\bar{t}$$ → lepton+jets events, which reduces the otherwise limiting systematic uncertainty from the jet energy scale. The measured mass is 173.11 ± 1.34(stat)+0.83 -0.72(sys) GeV .
Perioperative Management in the Collegiate Athlete: An Integrated Approach

Abstract Collegiate athletes face rigorous physical, academic, and emotional demands. While significant attention has been paid to injury prevention among young athletes in the past two decades, orthopedic injury rates remain high among collegiate athletes, and a significant number will undergo surgical management for injuries each year. In this narrative review, we describe techniques for perioperative management of pain and stress after surgery in collegiate athletes. In particular, we outline pharmacologic and non-pharmacologic management of surgical pain, with a goal of minimizing opiate consumption. We emphasize a multi-disciplinary approach to optimizing post-operative recovery in collegiate athletes help minimize reliance on opiate pain medication. Additionally, we recommend that institutional resources should be harnessed to support athletes in their well-being, from a nutritional, psychological and sleep standpoint. Critical to success in perioperative pain management is the communication among the athletic medicine team members and with the athlete and family to address pain and stress management and encourage timely, safe return to play.
Cerebral haemodynamics in symptomatic intracranial atherosclerotic disease: a narrative review of the assessment methods and clinical implications

Intracranial atherosclerotic disease (ICAD) is a common cause of ischaemic stroke and transient ischaemic attack (TIA) with a high recurrence rate. It is often referred to as intracranial atherosclerotic stenosis (ICAS), when the plaque has caused significant narrowing of the vessel lumen. The lesion is usually considered ‘symptomatic ICAD/ICAS’ (sICAD/sICAS) when it has caused an ischaemic stroke or TIA. The severity of luminal stenosis has long been established as a prognostic factor for stroke relapse in sICAS. Yet, accumulating studies have also reported the important roles of plaque vulnerability, cerebral haemodynamics, collateral circulation, cerebral autoregulation and other factors in altering the stroke risks across patients with sICAS. In this review article, we focus on cerebral haemodynamics in sICAS. We reviewed imaging modalities/methods in assessing cerebral haemodynamics, the haemodynamic metrics provided by these methods and application of these methods in research and clinical practice. More importantly, we reviewed the significance of these haemodynamic features in governing the risk of stroke recurrence in sICAS. We also discussed other clinical implications of these haemodynamic features in sICAS, such as the associations with collateral recruitment and evolution of the lesion under medical treatment, and indications for more individualised blood pressure management for secondary stroke prevention. We then put forward some knowledge gaps and future directions on these topics.
Paths to hippocampal damage in neuromyelitis optica spectrum disorders

Many patients with neuromyelitis optica spectrum disorders (NMOSD) suffer from cognitive impairment affecting memory, processing speed and attention and suffer from depressive symptoms. Because some of these manifestations could trace back to the hippocampus, several magnetic resonance imaging (MRI) studies have been performed in the past, with a number of groups describing volume loss of the hippocampus in NMOSD patients, whereas others did not observe such changes. Here, we addressed these discrepancies.
PEG-liposomal doxorubicin as a potential agent for canine metastatic osteosarcoma – in vitro and ex ovo studies

Abstract Introduction Appendicular osteosarcoma (OSA) is a highly aggressive and metastatic primary bone tumour in dogs. Standard therapy is amputation and adjuvant chemotherapy (e.g. with doxorubicin). Liposomal drug delivery may augment therapeutic efficacy and reduce negative side effects. Polyethylene glycol (PEG)-liposomal doxorubicin treats human metastatic cancers effectively. The study aimed was to evaluate PEG-liposomal doxorubicin’s inhibitory effect on canine metastatic proliferation and migration in vitro. It also aimed to appraise the drug’s extravasation inhibition in vivo using the human medicine–proven chick embryo chorioallantoic membrane ex ovo model. Material and Methods The canine D-17 OSA cell line was cultured and inoculated with decreasing concentrations of PEG-liposomal doxorubicin and conventional doxorubicin in a 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) test of cell viability, proliferation and cytotoxicity. Flow cytometry with Annexin V and Draq 7 staining confirmed the MTT test results, indicating dead, early and late apoptotic, and live cells. The inhibitory effect of the two preparations on cancer cell migration was investigated with a wound-healing assay. Culture plates seeded with cells were prepared. The cell monolayer was scratched and images of cells migrating to the scratch were captured at 0 h, 12 h and 24 h. Also, embryos were removed from three-day-incubated fertilised chicken eggs. On the 12th day, labelled D-17 cells were injected into each embryo. Embryos in one group received 100 μL of phosphate-buffered saline as controls, those in another group 30 μg/mL of PEG-liposomal doxorubicin, and those in the last group 6 μg/mL of conventional doxorubicin. The effectiveness of the intravascular administration of the D-17 cells was confirmed under a microscope. Results PEG-liposomal doxorubicin inhibited the migration of canine OSA cells more effectively than conventional doxorubicin (P ≤ 0.05). The ex ovo model showed that both drugs had similar impacts on canine metastatic OSA. Conclusion The liposomal form of the drug may be considered a potentially effective compound in canine metastatic OSA; nevertheless, further in vivo studies are essential to confirm this hypothesis.
Study on modeling of flow induced noise using Lighthill's analogy and boundary element method

We have calculated the flow-induced sound pressure field using Lighthill’s acoustic analogy by means of an acoustic boundary element method (BEM). For this calculation, firstly, an unsteady flow field is calculated using a computational fluid dynamics (CFD) solver. Then acoustic sources are extracted from the result and transformed into the frequency domain. Finally, these are used as quadrupole acoustic sources in the acoustic BEM model. In the BEM calculation, because some of the CFD grid points exist quite close to the BEM elements, for example 100 times smaller than the element length, so the contribution from the sources must be evaluated quite preciously. To achieve this, the elemental integration of the source contribution is introduced. We have validated the procedure (CFD/BEM approach) by comparing with an experimental data. The first validation is a comparison of the acoustic pressure generated by a low Mach number flow past a 3D circular cylinder. The second validation is a comparison of the acoustic pressure induced by a low Mach number flow in a bending duct. Finally the transmitting acoustic pressure which is originally induced by a flow through an elastic structure is calculated by the structural-acoustic coupled model.
Analysis of the immersed boundary method for Stokes flow

The immersed boundary method is a numerical scheme for dynamical simulations of solid or elastic bodies immersed in a surrounding fluid. The method was originally introduced by Peskin to model the flow of blood in the human heart. It has since proven to be a general and robust method for diverse flow problems arising in biology and engineering. Recently, the immersed boundary method has been applied to biological problems at the micro-scale or smaller, including swimming microorganisms and biomolecular motors. At these scales, the Stokes equations govern the dynamics of the surrounding fluid, and it is particularly important to represent accurately the hydrodynamic interactions that govern the motion of immersed bodies. In this thesis, we construct a new version of the immersed boundary method for Stokes flow. Our analysis of this new method sheds light on several fundamental questions about the immersed boundary method. In the new method, the structures are immersed in an infinite three-dimensional fluid; no artificial boundaries are necessary. Although we start from a discrete representation of the fluid on an infinite grid, we are able to eliminate the fluid variables and reduce the dynamics to that of a finite collection of Lagrangian points. Asymptotic methods reduce the computational cost and reveal the magnitudes of the numerical errors, as well as the dependence of these errors on the approximate delta function used to regularize singular sources.