Miracle-dz/UniFAR-FTUs huggingface dataset:
New specimens and species of the Oligocene toothed baleen whale Coronodon from South Carolina and the origin of Neoceti

Baleen whales (Mysticeti) are gigantic filter-feeding cetaceans possessing the unique soft tissue structure baleen and lacking adult teeth; Oligocene fossils have revealed a wealth of early diverging tooth-bearing mysticetes highlighting the transition from archaeocete ancestors to early toothless baleen-bearing eomysticetid whales. The archaeocete-like, toothed mysticete Coronodon havensteini from the lower Oligocene Ashley Formation of South Carolina possesses a number of peculiar aspects of feeding morphology suggesting dental filter-feeding in the earliest diverging mysticete lineage. New fossils of Coronodon are described in detail, including (1) supplementary description of the holotype skull and skeleton of Coronodon havensteini; (2) description of two new juvenile skulls of C. havensteini and a partial skull and postcranial skeleton of an adult; (3) description of the new species Coronodon planifrons n.sp. ; and (4) description of the new species Coronodon newtonorum. New specimens of Coronodon havensteini include a partial adult skeleton preserving new elements for the species including incisors, numerous upper premolars and molars, lower m4, scapula, lumbar, and caudal vertebrae, and two juvenile skulls with tympanoperiotics and teeth. Fossils from the overlying unit, the Chandler Bridge Formation, represent two new species: Coronodon newtonorum n. sp. and Coronodon planifrons n. sp. Coronodon newtonorum possesses a concave-up alveolar profile, a mandibular condyle elevated far above the toothrow, and a gracile periotic resembling those of juvenile C. havensteini. Coronodon planifrons n. sp. possesses a horizontal supraorbital process, successively smaller upper molars, massively inflated periotic, and longer intertemporal region. Coronodon planifrons n. sp. preserves one of the most complete vertebral columns among toothed mysticetes, indicating nine thoracic vertebrae, ten lumbar vertebrae, and at least 20 caudal vertebrae. The column exhibits a somewhat stabilized caudal peduncle with enlarged lumbocaudal vertebrae, and rectangular terminal caudals indicate the presence of tail flukes. Juvenile skulls reveal several ontogenetic trends in Coronodon havensteini, including the anterior migration of the orbitotemporal crest, anteroposterior elongation of the intertemporal region, inflation of the body of the periotic, enlargement of the tympanic bulla, and continued postnatal emergence of the premolars and molars from their alveoli. Disarticulated skulls suggest a degree of rostral kinesis in this genus. Phylogenetic analysis of the largest assembled supermatrix of Mysticeti (n =138 OTUs; four archaeocetes, 10 odontocetes, 124 mysticetes; 391 morphological and 27,225 molecular characters) confirms placement of Coronodon as the earliest diverging lineage of Mysticeti under equally weighted analyses whereas implied weighting places Coronodon and similar taxa outside Neoceti, prompting a review of character transformations at the base of Neoceti.
A snap-shot of a diarrheal epidemic in Dhaka due to enterotoxigenic Escherichia coli and Vibrio cholerae O1 in 2022

Background Enterotoxigenic Escherichia coli (ETEC) and Vibrio cholerae O1 are most common bacterial causes of diarrheal diseases in Bangladesh. This analysis projected distribution of ETEC and V. cholerae O1 among diarrheal patients of icddr,b, Dhaka hospital in two diarrheal peaks of 2022. Methodology Under the 2% systematic surveillance system, stool samples collected from diarrheal patients of icddr,b hospital were cultured and diagnostic testing was done for ETEC and V. cholerae O1. Comparison of positive cases was done between first peak (March–April) and second peak (October–November) in 2022. Results A total of 2,937 stool specimens were tested of which 12% were ETEC and 20% were V. cholerae O1. About 40% of the severe dehydration cases were infected with V. cholerae O1. Predominant ETEC enterotoxin type was ‘LT/ST’ (41%). The LT enterotoxin significantly increased from 13% to 28% in the second peak (p = 0.015). The predominant colonization factors (CFs) on ETEC were CS5 + CS6 (23%), followed by CS6 (15%). CF-positive isolates was significantly higher in the second peak (36%) than in the first peak (22%) (p = 0.043). Total 14% cases were co-infected with ETEC and V. cholerae O1. Significant differences in the distribution of enterotoxin types were observed (p = 0.029) among the co-infection cases. Conclusion Changing patterns of enterotoxin and CFs observed in ETEC pathogens should be taken into consideration for ETEC vaccine development. Considering cholera and ETEC biannual trends in causing diarrheal epidemics and outbreaks, emphasizes the need for thoughts on combination vaccine strategies for preventing acute watery diarrhea due to the two major bacterial pathogens.
Designing Ecological Auditory Feedback on Lower Limb Kinematics for Hemiparetic Gait Training

Auditory feedback has earlier been explored as a tool to enhance patient awareness of gait kinematics during rehabilitation. In this study, we devised and tested a novel set of concurrent feedback paradigms on swing phase kinematics in hemiparetic gait training. We adopted a user-centered design approach, where kinematic data recorded from 15 hemiparetic patients was used to design three feedback algorithms (wading sounds, abstract, musical) based on filtered gyroscopic data from four inexpensive wireless inertial units. The algorithms were tested (hands-on) by a focus group of five physiotherapists. They recommended that the abstract and musical algorithms be discarded due to sound quality and informational ambiguity. After modifying the wading algorithm (as per their feedback), we conducted a feasibility test involving nine hemiparetic patients and seven physiotherapists, where variants of the algorithm were applied to a conventional overground training session. Most patients found the feedback meaningful, enjoyable to use, natural-sounding, and tolerable for the typical training duration. Three patients exhibited immediate improvements in gait quality when the feedback was applied. However, minor gait asymmetries were found to be difficult to perceive in the feedback, and there was variability in receptiveness and motor change among the patients. We believe that our findings can advance current research in inertial sensor-based auditory feedback for motor learning enhancement during neurorehabilitation.
Security Risks and User Perception towards Adopting Wearable Internet of Medical Things

The Wearable Internet of Medical Things (WIoMT) is a collective term for all wearable medical devices connected to the internet to facilitate the collection and sharing of health data such as blood pressure, heart rate, oxygen level, and more. Standard wearable devices include smartwatches and fitness bands. This evolving phenomenon due to the IoT has become prevalent in managing health and poses severe security and privacy risks to personal information. For better implementation, performance, adoption, and secured wearable medical devices, observing users’ perception is crucial. This study examined users’ perspectives of trust in the WIoMT while also exploring the associated security risks. Data analysed from 189 participants indicated a significant variance (R2 = 0.553) on intention to use WIoMT devices, which was determined by the significant predictors (95% Confidence Interval; p < 0.05) perceived usefulness, perceived ease of use, and perceived security and privacy. These were found to have important consequences, with WIoMT users intending to use the devices based on the trust factors of usefulness, easy to use, and security and privacy features. Further outcomes of the study identified how users’ security matters while adopting the WIoMT and provided implications for the healthcare industry to ensure regulated devices that secure confidential data.
Synthesis of Novel 2-(Cyclopentylamino)thiazol-4(5H)-one Derivatives with Potential Anticancer, Antioxidant, and 11β-HSD Inhibitory Activities

In this study, a series of nine new 2-(cyclopentylamino)thiazol-4(5H)-one derivatives were synthesized, and their anticancer, antioxidant, and 11β-hydroxysteroid dehydrogenase (11β-HSD) inhibitory activities were tested. Anticancer activity has been assessed using the MTS (MTS: 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium) assay against human colon carcinoma (Caco-2), human pancreatic carcinoma (PANC-1), glioma (U-118 MG), human breast carcinoma (MDA-MB-231), and skin melanoma (SK-MEL-30) cancer cell lines. Cell viability reductions, especially in the case of Caco-2, MDA-MB-231, and SK-MEL-30 lines, were observed for most compounds. In addition, the redox status was investigated and oxidative, but nitrosative stress was not noted at a concentration of 500 µM compounds tested. At the same time, a low level of reduced glutathione was observed in all cell lines when treated with compound 3g (5-(4-bromophenyl)-2-(cyclopentylamino)thiazol-4(5H)-one) that most inhibited tumor cell proliferation. However, the most interesting results were obtained in the study of inhibitory activity towards two 11β-HSD isoforms. Many compounds at a concentration of 10 µM showed significant inhibitory activity against 11β-HSD1 (11β-hydroxysteroid dehydrogenase type 1). The compound 3h (2-(cyclopentylamino)-1-thia-3-azaspiro[4.5]dec-2-en-4-one) showed the strongest 11β-HSD1 inhibitory effect (IC50 = 0.07 µM) and was more selective than carbenoxolone. Therefore, it was selected as a candidate for further research.
A Proposal for an “Environmental Sports Journalism” (ESJ) Approach: Principles and Illustrative Examples From Coverage of the Rio 2016 and PyeongChang 2018 Olympic and Paralympic Games

This article introduces/rationalizes an attempt to conceptualize “environmental sports journalism (ESJ). ” ESJ refers to a set of principles for analyzing and/or reporting on media coverage of sport-related environmental issues—principles intended to support/promote dialogue and nuanced thinking about these issues and about how sports journalism might contribute to environmentally friendly and just outcomes. To clarify features of ESJ and explore benefits/challenges of ESJ, we include illustrative examples of ESJ from media coverage of: (a) polluted harbor water used for the 2016 Rio Olympic and Paralympic Summer Games and (b) the razing of an ancient forest for a ski facility for the 2018 PyeongChang Olympic and Paralympic Winter Games. We conclude with reflections on the potential/limits of ESJ and suggestions for work on sport, journalism, and environmental issues.
Relationship between psychopathy, personality and human values in a prison sample

Abstract Our aim was to understand to what extent the characteristics of psychopathy are correlated with personality traits and human values in a sample of imprisoned inmates. To this end, a total of 56 prisoners were evaluated, predominantly female (80.4%) with a mean age of 33.44 (SD=7.15). The following instruments were employed: (1) Hare scale, (2) Human Values Questionnaire (BVQ), (3) Big Five Personality Traits Inventory (BFI-S) and (4) Demographic Questionnaire. Descriptive statistics and Spearman’s rank correlation coefficient were applied. The results indicated a positive correlation between a socially deviant/antisocial lifestyle (Factor 2) and the dimensions of neuroticism (r s =0.44; p<0.001), openness to experience in the BFI-S (r s =0.26; p<0.05) and experimentation in the BVQ (r s =0.36; p<0.001). It was concluded that the present study contributes to an understanding of personality traits and values related to psychopathy, expanding the nomological network of this construct.
Nrf2 Protein Serum Concentration in Human CKD Shows a Biphasic Behavior

Oxidative stress contributes to the progression of chronic kidney disease (CKD) and CKD-related mortality. The nuclear factor erythroid 2-related factor 2 (Nrf2) is essential in the regulation of cellular redox status, and Nrf2-activating therapies are under evaluation in several chronic diseases, including CKD. It is therefore inevitable to understand how Nrf2 behaves in advancing CKD. We analyzed Nrf2 protein concentrations in patients with varying extents of CKD but without renal replacement therapy, and in healthy subjects. Compared to healthy controls, Nrf2 protein was upregulated in mild to moderate kidney function impairment (G1–3). Within the CKD population, we found a significant positive correlation between Nrf2 protein concentration and kidney function (estimated glomerular filtration rate). In severe kidney function impairment (G4,5), Nrf2 protein was reduced compared to mild to moderate kidney function impairment. We conclude that Nrf2 protein concentration in severe kidney function impairment is reduced relative to the mild to moderate kidney function impairment where increased Nrf2 protein concentrations prevail. With respect to the implementation of Nrf2 targeted therapies, it will be necessary to explore in which population of patients with CKD such therapies are able to effectively add to the endogenous Nrf2 activity.
Solar Sail Trajectories to Earth’s Trojan Asteroids

The recent discovery of Earth’s second Trojan asteroid (2020 XL5), which will remain in the vicinity of the Sun–[Earth+Moon] triangular Lagrangian point L4 for at least 4000 years, has attracted the attention of the scientific community as a remarkable example of those elusive objects that are the witnesses of the first phase of our Solar System. The possibility that an Earth’s Trojan asteroid (ETa) may represent a pristine record of the initial conditions of the Solar System formation makes these small objects an interesting target for a robotic exploration mission. This paper analyzes orbit-to-orbit Earth–ETa transfer trajectories of an interplanetary spacecraft propelled by a solar sail. In the last decade, some pioneering space missions have confirmed the feasibility and potentiality of the solar sail concept as a propellantless propulsion system able to convert the solar radiation pressure in a continuous thrust by means of a large, lightweight and highly reflective surface. Using the state-of-the-art level of solar sail technology, this paper studies the performance of a solar-sail-based transfer trajectory toward an ETa from an optimal viewpoint and with a parametric approach.
Dark Matter Particle Astrophysics: How Dark Matter Can Affect Subhalos, Neutrinos, and Neutron Stars

Dark Matter Particle Astrophysics: How Dark Matter Can A ect Subhalos, Neutrinos, and Neutron Stars Bridget Bertoni Chair of the Supervisory Committee: Professor Ann Nelson Physics Predicted almost a century ago, dark matter explains many astrophysical observations including the motion of matter on galaxy and galaxy cluster scales, the clustering of galaxies, and the anisotropies in the cosmic microwave background. The standard cosmological model further predicts that 26% of the universe consists of dark matter, however we have yet to understand how, if at all, dark matter interacts with the rest of the known particles outside of gravity. Though hints of non-gravitational dark matter interactions exist, most experimental and observational searches only place upper limits on the strength of these interactions. In this thesis, we summarize the current knowledge of dark matter and then focus on three di erent astrophysical probes of non-gravitational dark matter interactions: 1) dark matter annihilation in subhalos, 2) dark matter-neutrino interactions, and 3) dark matter collection in neutron stars.
Human Poisoning with Methomyl and Cypermethrin Pesticide Mixture

There is limited literature analyzing the outcome of human poisoning with methomyl and cypermethrin pesticide mixture. Between 2002 and 2018, a total of 63 patients intoxicated with methomyl, cypermethrin, or their pesticide mixture were treated at Chang Gung Memorial Hospital. The patients were categorized into three groups based on the type of pesticide, as methomyl (n = 10), cypermethrin (n = 31), or methomyl and cypermethrin (n = 22). Demographic, clinical, laboratory, and mortality data were obtained for analysis. The patients were aged 54.9 ± 18.9 years. Following ingestion, the patients experienced a wide range of clinical symptoms, including aspiration pneumonia (50.8%), acute respiratory failure (41.3%), acute kidney injury (33.3%), multiple organ failure (19.0%), emesis (19.0%), acute hepatitis (12.7%), diarrhea (7.9%), seizures (4.8%), lacrimation (4.8%), etc. After analysis, it was found that patients with methomyl and cypermethrin poisoning suffered higher incidences of acute respiratory failure (p < 0.001), aspiration pneumonia (p = 0.004), acute kidney injury (p = 0.011), and multiple organ failure (p < 0.001) than the other groups. Laboratory analyses revealed that patients with methomyl and cypermethrin poisoning had a higher creatinine level (p = 0.011), white blood cell count (p < 0.001), and neutrophil count (p = 0.019) than the other groups. A total of seven (11.1%) patients died. The average duration of hospitalization was 9.8 ± 10.0 days. In a multivariate logistic regression model, it was revealed that methomyl pesticide (p = 0.045) or methomyl and cypermethrin pesticide mixture (p = 0.013) were significant risk factors for acute respiratory failure. Nevertheless, no mortality risk factor could be identified. Therefore, the analytical results suggest that methomyl pesticide is the major contributor to the toxicity of methomyl and cypermethrin pesticide mixture poisoning. More research is needed.
Phytoceramides from the Marine Sponge Monanchora clathrata: Structural Analysis and Cytoprotective Effects

In our research on sphingolipids from marine invertebrates, a mixture of phytoceramides was isolated from the sponge Monanchora clathrata (Western Australia). Total ceramide, ceramide molecular species (obtained by RP-HPLC, high-performance liquid chromatography on reversed-phase column) and their sphingoid/fatty acid components were analyzed by NMR (nuclear magnetic resonance) spectroscopy and mass spectrometry. Sixteen new (1b, 3a, 3c, 3d, 3f, 3g, 5c, 5d, 5f, 5g, 6b–g) and twelve known (2b, 2e, 2f, 3b, 3e, 4a–c, 4e, 4f, 5b, 5e) compounds were shown to contain phytosphingosine-type backbones i-t17:0 (1), n-t17:0 (2), i-t18:0 (3), n-t18:0 (4), i-t19:0 (5), or ai-t19:0 (6), N-acylated with saturated (2R)-2-hydroxy C21 (a), C22 (b), C23 (c), i-C23 (d), C24 (e), C25 (f), or C26 (g) acids. The used combination of the instrumental and chemical methods permitted the more detailed investigation of the sponge ceramides than previously reported. It was found that the cytotoxic effect of crambescidin 359 (alkaloid from M. clathrata) and cisplatin decreased after pre-incubation of MDA-MB-231 and HL-60 cells with the investigated phytoceramides. In an in vitro paraquat model of Parkinson’s disease, the phytoceramides decreased the neurodegenerative effect and ROS (reactive oxygen species) formation induced by paraquat in neuroblastoma cells. In general, the preliminary treatment (for 24 or 48 h) of the cells with the phytoceramides of M. clathrata was necessary for their cytoprotective functions, otherwise the additive damaging effect of these sphingolipids and cytotoxic compounds (crambescidin 359, cisplatin or paraquat) was observed.
Optimized Proactive Recovery in Erasure-Coded Cloud Storage Systems

Cloud data centers have started utilizing erasure coding in large-scale storage systems to ensure high reliability with limited overhead compared to replication. However, data recovery in erasure coding incurs high network bandwidth consumption compared to replication. Cloud storage systems also play an important role in the energy consumption of data centers. Heuristic proactive recovery algorithms select all data blocks from failure-predicted disk/machine and perform proactive replication that contributes to huge recovery bandwidth savings. However, they fail to optimize the selection. Optimization can further improve resource savings. To address this issue, we propose a recovery algorithm that applies minimization on data blocks selected for proactive replication by considering the necessary and appropriate constraints that are constructed based on the system’s current network traffic and data duplication information. We evaluate the proposed algorithm using extensive simulations. Experiments show that the recovery algorithm reduces network traffic by 60% and storage overhead by 46% compared to the heuristic proactive recovery approach. Also, the proposed proactive recovery methods reduce the storage system’s energy consumption by up to 52% compared to replication.
Resilience and vulnerability of discourse-conditioned word order in heritage Spanish

Abstract Heritage speakers—bilinguals who acquire minority languages naturalistically in infancy but are typically majority-language-dominant in adulthood—generally acquire grammars that differ systematically from the baseline input received in childhood. Yet not all areas diverge equally; understanding what characterizes divergence or resilience of a given feature is crucial to understanding heritage language acquisition. In this realm, we investigate the discourse-conditioned non-canonical word orders that mark information focus in Spanish. Focus bears the hallmarks of structures that diverge from the baseline, yet the evidence is mixed. We use an offline forced-choice task and an online self-paced reading task to compare heritage speakers’ judgments and processing to the baseline’s, and we find, echoing recent work, that the heritage speakers largely resemble baseline speakers. We interpret this convergence with reference to seven factors potentially affecting heritage language acquisition and identify one hypothesis—that focus facilitates processing due to its structural and pragmatic salience—as a promising explanation.
The Effect of Strategic Vigilance on Organizational Excellence the Mediating Role of Strategic Foresight

This study aimed to identify the impact of strategic vigilance on organizational excellence through the mediating role of strategic foresight, the study was applied in the jordan commercial banks which are (13) banks. A questionnaire was used as to collect data to investigating the opinions of a sample of (217) manager. (171) questionnaires were collected . The most important findings the study reached were there are a statistically significant impact at the level of significance (P≤0.05) of strategic vigllance on organizational excellence, and a statistically significant direct impact at the level of significance(P≤ 0.05) of strategic viglance on organizational excellence in the presence of strategic foresight. With the most notably recommendations: the Jordan Commercial Banks should focus on strategic vigilance, as it is one of the most important means to improve organization excellence, developing awareness among the leaders and employees of commercial banks about the fundamental,and entrepreneurship role of efficient management to anticipate the future and enhance organizational excellence. As well as enhancing the foresight capabilities, and mechanisms of strategic foresight for the future.
Solutions globales des équations d’Einstein-Maxwell

En adaptant une methode de Lindblad et Rodnianski, on prouve l'existence de solutions globales pour les equations d'Einstein-Maxwell en dimension d'espace n ≥ 3. Les donnees initiales considerees sont lisses, asymptotiquement euclidiennes et suffisamment petites. On utilise la jauge harmonique et la jauge de Lorenz.