Miracle-dz/UniFAR-FTUs huggingface dataset:
Speckle Tracking Echocardiography in Hypertensive Pregnancy Disorders: A Systematic Review

Importance Hypertensive pregnancy disorders (HPDs) are associated with an increased risk of long-term cardiovascular disease. Speckle tracking echocardiography (STE) might be useful in the early detection of preclinical cardiac changes in women with HPDs. Objective The aim of this study was to study whether STE is a suitable method to detect differences in cardiac function in pregnant women with HPD compared with normotensive pregnant women or between women with a history of a pregnancy complicated by HPD compared with women with a history of an uncomplicated pregnancy. Evidence Acquisition The databases Medline, EMBASE, and Central were systematically searched for studies comparing cardiac function measured with STE in pregnant women with HPD or women with a history of HPD and women with a history of normotensive pregnancies. Results The search identified 16 studies, including 870 women with a history of HPD and 693 normotensive controls. Most studies during pregnancy (n = 12/13) found a decreased LV-GLS (left ventricular global longitudinal strain) in HPD compared with normotensive pregnant controls. LV-GRS (left ventricular global radial strain) and LV-GLCS (left ventricular global circumferential strain) are decreased in women with early-onset and severe preeclampsia. Women with a history of early-onset preeclampsia show lasting myocardial changes, with significantly decreased LV-GLS, LV-GLCS, and LV-GRS. Conclusions and Relevance LV-GLS is significantly decreased in pregnant women with HPD compared with normotensive pregnant women. Other deformation values show a significant decrease in women with severe or early-onset preeclampsia, with lasting myocardial changes after early-onset preeclampsia. Target Audience Obstetricians and gynecologists, family physicians, cardiologists. Learning Objectives After participating in this activity, the learner should be better able to identify the test characteristics of STE; describe the differences in STE between HPDs and normotensive pregnant controls; and explain which HPD causes lasting myocardial changes after pregnancy.
Spin‐inversion mechanisms in O2 binding to a model heme compound: A perspective from nonadiabatic wave packet calculations

Spin‐inversion dynamics in O2 binding to a model heme complex, which consisted of Fe(II)‐porphyrin and imidazole, were studied using nonadiabatic wave packet dynamics calculations. We considered three active nuclear degrees of freedom in the dynamics, including the motions along the Fe–O distance, Fe–O–O angle, and Fe out‐of‐plane distance. Spin‐free potential energy surfaces for the singlet, triplet, quintet, and septet states were developed using density functional theory calculations, and spin–orbit coupling elements were obtained from CASSCF‐level electronic structure calculations. The spin‐inversion mainly occurred between the singlet state and one of the triplet states due to large spin–orbit couplings and the contributions of other states were extremely small. The present quantum dynamics calculations suggested that the narrow crossing region model plays a dominant role in the O2 binding dynamics. In addition, the one‐dimensional Landau–Zener model underestimated the nonadiabatic transition probability.
Anticoagulant protein S in COVID-19: low activity, and associated with outcome

Abstract Introduction. COVID-19 disease was associated with both thrombo-embolic events and in-situ thrombi formation in small vessels. Antiphospholipidic antibodies were found in some studies. Aim. Assessment of protein S activity in patients with COVID-19 as a cause of this prothrombotic state, and of the association of protein S activity with worse outcome. Methods. All patients admitted for COVID-19 disease in a university hospital between 15th of May and 15th of July 2020 were prospectively enrolled into this cohort study. Patients treated with antivitamin K anticoagulants and with liver disease were excluded. All patients had protein S activity determined at admission. The main outcome was survival, while secondary outcomes were clinical severity and lung damage. Results. 91 patients were included, of which 21 (23.3%) died. Protein S activity was decreased in 65% of the patients. Death was associated with lower activity of protein S (median 42% vs. 58%, p < 0.001), and the association remained after adjustment for age, inflammation markers and ALAT. There was a dose-response relationship between protein S activity and clinical severity (Kendall_tau coefficient = –0.320, p < 0.001; Jonckheere-Terpstra for trend: p < 0.001) or pulmonary damage on CT scan (Kendall_tau coefficient = –0.290, p < 0.001; Jonckheere-Terpstra for trend: p < 0.001). High neutrophil count was also independently associated with death (p = 0.002). Conclusion. Protein S activity was lower in COVID-19 patients, and its level was associated with survival and disease severity, suggesting that it may have a role in the thrombotic manifestations of the disease.
The levels of bioactive ingredients in Citrus aurantium L. at different harvest periods and antioxidant effects on H2 O2 -induced RIN-m5F cells.

BACKGROUND Citrus aurantium L. (Aurantii fructus) is a multi-purpose citrus fruit with high medicinal and nutritional value, but currently there is no data that can be used to investigate its appropriate harvest time to obtain high-quality citrus bioactive ingredients. RESULTS Phytochemicals and levels of the main bioactive ingredients were investigated by UHPLC-ESI-Q-TOF/MS. The contents of flavanones, polymethoxyflavones, coumarins, synephrine, and limonin in citrus fruit were analyzed at different harvest periods, and significant differences ranging from 0.03 ± 0.01 to 116.26 ± 40.20 g kg-1 (DW) were shown. These compounds were present in higher amounts in June and then decreased gradually, while biomass accumulation of most of them showed an increasing tendency along the harvest times. The H2 O2 -induced RIN-m5F cells model was employed to evaluate their antioxidant capacity. Citrus fruit harvested from June 11 to July 7 possessed an excellent antioxidant capacity by inhibiting the intensity of intracellular reactive oxygen species (ROS) (p < 0.01) and improving superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH) activities (p < 0.01). In addition, chemical compositions and antioxidant capacities of citrus leaves, stems, and roots were evaluated, and these showed great variation compared with citrus fruits. Multivariate statistical analysis indicated that harvesting time was related closely to the phytochemical contents and antioxidant capacity. CONCLUSION Citrus fruit can be appropriately harvested from June to early July when the levels of bioactive ingredients and antioxidant activity reach higher values. This research provides practical information for producing high-quality citrus products. This article is protected by copyright. All rights reserved.
Drug Repurposing for Candidate SARS-CoV-2 Main Protease Inhibitors by a Novel In Silico Method

The SARS-CoV-2 outbreak caused an unprecedented global public health threat, having a high transmission rate with currently no drugs or vaccines approved. An alternative powerful additional approach to counteract COVID-19 is in silico drug repurposing. The SARS-CoV-2 main protease is essential for viral replication and an attractive drug target. In this study, we used the virtual screening protocol with both long-range and short-range interactions to select candidate SARS-CoV-2 main protease inhibitors. First, the Informational spectrum method applied for small molecules was used for searching the Drugbank database and further followed by molecular docking. After in silico screening of drug space, we identified 57 drugs as potential SARS-CoV-2 main protease inhibitors that we propose for further experimental testing.
Predicting the Invasion Potential of the Lily Leaf Beetle, Lilioceris lilii Scopoli (Coleoptera: Chrysomelidae), in North America

Simple Summary The lily leaf beetle, Lilioceris lilii Scopoli (Coleoptera: Chrysomelidae), is an invasive pest of cultivated and native lilies (Liliaceae). This Eurasian beetle was introduced to North America in 1943, and can now be found in nine provinces and 14 states. The lily leaf beetle has already been found feeding and reproducing on several eastern species of native lilies. To help predict where L. lillii will be able to establish in North America and which native Liliaceae species will be vulnerable to attack, a habitat suitability model was created. This model uses specimen location data along with environmental data to produce habitat suitability estimates between 0 (low suitability) and 1 (high suitability). Model results indicate that the beetle should be able to establish throughout the range of most North American Liliaceae, including species of special conservation concern. With the increased utilization of habitat suitability models in conservation management, this model should be consulted, to help plan preemptive monitoring and control efforts for L. lilii in regions, with Liliaceae species of conservation concern. Abstract Invasive species are among the leading threats to global ecosystems due to impacts on native flora and fauna through competition and predation. The lily leaf beetle, Lilioceris lilii Scopoli (Coleoptera: Chrysomelidae), is an invasive pest of lilies (Lilium spp.) and other genera of Liliaceae (Liliales). A habitat suitability model was created using Maxent, to help predict if L. lilii will be able to establish in locations were native North American Liliaceae species grow. The model was created using georeferenced occurrence records from the beetle’s native, naturalized, and invasive range. Model results indicate that precipitation in the driest quarter and annual average temperatures are most strongly correlated with L. lilii distribution, and suggest that the species will perform poorly in very dry, hot, or cold environments. The model also indicates that the beetle should be able to establish throughout the range of most North American Liliaceae genera, including species of special conservation concern. This model can be used by natural area managers to identify areas of high habitat suitability that overlap with vulnerable North American Liliaceae species, and prioritize L. lilii monitoring and control activities as the beetle continues to expand its range.
Combating Fear of Missing Out (FoMO) on Social Media: The FoMO-R Method

Background: The fear of missing out (FoMO) on social media refers to the apprehension that online content and interactions from others are unseen and reacted to in a timely fashion. FoMO can become problematic, leading to anxiety, interrupted sleep, lack of concentration and dependence on social media to generate gratification. The literature has mainly focused on understanding the FoMO experience, factors contributing to it and its consequences. Method: In this paper, we build on previous research and develop a FoMO Reduction (FoMO-R) approach that embraces technical elements such as autoreply, filtering, status, education on how FoMO occurs and skills on how to deal with it; e.g., self-talk and checklists. We evaluate the method through focus groups and a diary study involving 30 participants who self-declared to experience FoMO regularly. Results: The results show that the method was accepted by the participants and helped them to manage their FoMO. They also show that a set of extra functionalities in social media design is needed so that users can manage FoMO more effectively. Conclusion: FoMO can be reduced through socio-technical approaches, joining both social and technical skills, and literacy on how social media are designed and how social interactions should happen on them.
The Mechanical Properties of Kevlar Fabric/Epoxy Composites Containing Aluminosilicates Modified with Quaternary Ammonium and Phosphonium Salts

We investigated the effect of modified aluminosilicates, including bentonite from Armenia (BA) modified with quaternary ammonium salts (BAQAS) and phosphonium salts (BAQPS), on the mechanical properties and morphology of Kevlar/epoxy composites. The Kevlar/epoxy composites containing 1.0 or 3.0 wt. % modified bentonites were fabricated using the hand lay-up technique. The mechanical properties, including the tensile, flexural, and in-plane shear strength, were tested. Based on the obtained results, we found that the mechanical properties increased with modified bentonite loading. The best results were obtained for composites containing 3 wt. % BAQAS, as most of the mechanical properties were significantly improved (tensile strength 302.9 MPa (+30%), Young’s modulus 16.3 GPa (+17%), flexural modulus 23.4 GPa (+12.5%), in-plane shear strength 22.8 MPa (+24.5%), and in-plane shear modulus 677.2 MPa (+42%)). The obtained improvements in the mechanical properties are attributed to the uniform dispersion of the filler, which was confirmed by the highest increase in the intergallery spacing, from 28.3 Å for BAQAS to 45.1 Å for the composite with 3 wt. % BAQAS. Scanning electron microscopy (SEM) analysis of the brittle fracture surface indicated that the addition of modified bentonite to the epoxy matrix changed the morphology of the Kevlar/epoxy/organoclay composites and improved the fiber–matrix interfacial adhesion.
New technology on the horizon: Fast analytical screening technique FNA (FAST‐FNA) enables rapid, multiplex biomarker analysis in head and neck cancers

PD‐L1 profiling was recently approved by the US Food and Drug Administration as a companion diagnostic for anti‐PD1 treatment in patients with head and neck cancer, ushering in a new era for precision medicine. However, the routine development and implementation of such testing is still limited by current clinical workflows and the lack of better and more comprehensive alternatives. In this review, the authors discuss the real‐world challenges of clinically based biomarker testing and highlight the advantages of developing fine‐needle aspiration (FNA)‐based biomarker testing that would enable frequent and serial tumor sampling. A conceptual and technological innovation is introduced, fast analytical screening technique (FAST)‐FNA (FAST chemistry‐enabled FNA), which is being developed to inform immunotherapy treatment options in patients with head and neck cancer and to assist with the development of the next generation of predictive biomarkers.
Comparing the prioritization of items and feature-dimensions in visual working memory

Selective attention can be directed not only to external sensory inputs, but also to internal sensory representations held within visual working memory (VWM). To date, this phenomenon has been studied predominantly following retrospective cues directing attention to particular items, or their locations in memory. In addition to item-level attentional prioritization, recent studies have shown that selectively attending to feature dimensions in VWM can also improve memory recall performance. However, no study to date has directly compared item-based and dimension-based attention in VWM, nor their neural bases. Here, we compared the benefits of retrospective cues (retro-cues) that were directed either at a multifeature item or at a feature dimension that was shared between two spatially segregated items. Behavioral results revealed qualitatively similar attentional benefits in both recall accuracy and response time, but also showed that cueing benefits were larger after item cues. Concurrent electroencephalogram measurements further revealed a similar attenuation of posterior alpha oscillations following both item and dimension retro-cues when compared with noninformative, neutral retro-cues. We argue that attention can act flexibly to prioritize the most relevant information—at either the item or the dimension level—to optimize ensuing memory-based task performance, and we discuss the implications of the observed commonalities and differences between item-level and dimension-level prioritization in VWM.
Dietary antioxidants impact DDT resistance in Drosophila melanogaster

Insects experience a diversity of subtoxic and/or toxic xenobiotics through exposure to pesticides and, in the case of herbivorous insects, through plant defensive compounds in their diets. Many insects are also concurrently exposed to antioxidants in their diets. The impact of dietary antioxidants on the toxicity of xenobiotics in insects is not well understood, in part due to the challenge of developing appropriate systems in which doses and exposure times (of both the antioxidants and the xenobiotics) can be controlled and outcomes can be easily measured. However, in Drosophila melanogaster, a well-established insect model system, both dietary factors and pesticide exposure can be easily controlled. Additionally, the mode of action and xenobiotic metabolism of dichlorodiphenyltrichloroethane (DDT), a highly persistent neurotoxic organochlorine insecticide that is detected widely in the environment, have been well studied in DDT-susceptible and -resistant strains. Using a glass-vial bioassay system with blue diet as the food source, seven compounds with known antioxidant effects (ascorbic acid, β-carotene, glutathione, α-lipoic acid, melatonin, minocycline, and serotonin) were orally tested for their impact on DDT toxicity across three strains of D. melanogaster: one highly susceptible to DDT (Canton-S), one mildly susceptible (91-C), and one highly resistant (91-R). Three of the antioxidants (serotonin, ascorbic acid, and β-carotene) significantly impacted the toxicity of DDT in one or more strains. Fly strain and gender, antioxidant type, and antioxidant dose all affected the relative toxicity of DDT. Our work demonstrates that dietary antioxidants can potentially alter the toxicity of a xenobiotic in an insect population.
Calculated Ageism: Generational Sacrifice as a Response to the COVID-19 Pandemic

Abstract Objectives Popular responses to the pandemic illustrate ageism’s pervasiveness and the extent of collective acquiescence to its newest expressions. We explore these themes by analyzing Twitter reactions to “calculated ageism” – a term we use to refer to a political figure’s edict that older adults should sacrifice their lives if it will mitigate the pandemic’s economic damage to younger people. Methods Using thematic analysis, we examine tweets (n=188) responding to Texas Lt. Governor Dan Patrick’s March 23, 2020, statement that encouraged generational self-sacrifice. Themes that emerged included positions of support or opposition and tweeters’ critiques. Results The large majority of tweets – 90 percent – opposed calculated ageism, while only 5 percent supported it and 5 percent conveyed no position. Opposition centered on moral critiques, political-economic critiques, assertions of older adults’ worth, and public health arguments. Support centered on individual responsibility and patriotism. Discussion While prior research reveals ageism to be solidly entrenched in popular culture, our study finds that limits prevail and identifies the reasons underlying them. The most common reasons for opposing calculated ageism center on its immorality and on its privileging of the economic interests of the powerful few over the many, patterns suggesting that the boundaries of ageism are influenced by core beliefs about fairness. They also are shaped by a bedrock conviction that older lives have value. This intergenerational solidarity could be leveraged to reduce ageism during the pandemic and beyond.
Prediction of Mortality With the Use of Noninvasive Ventilation for Acute Respiratory Failure

BACKGROUND: In actuality, it is difficult to obtain an early prognostic stratification for patients with acute respiratory failure treated with noninvasive ventilation (NIV). We tested whether an early evaluation through a predictive scoring system could identify subjects at risk of in-hospital mortality or NIV failure. METHODS: This was a retrospective study, which included all the subjects with acute respiratory failure who required NIV admitted to an emergency department–high-dependence observation unit between January 2014 and December 2017. The HACOR (heart rate, acidosis [by using pH], consciousness [by using the Glasgow coma scale], oxygenation [by using PaO2/ FIO2], respiratory rate) score was calculated before the NIV initiation (T0) and after 1 h (T1) and 24 h (T24) of treatment. The primary outcomes were in-hospital mortality and NIV failure, defined as the need for invasive ventilation. RESULTS: The study population included 644 subjects, 463 with hypercapnic respiratory failure and an overall in-hospital mortality of 23%. Thirty-six percent of all the subjects had NIV as the “ceiling” treatment. At all the evaluations, nonsurvivors had a higher mean ± SD HACOR score than did the survivors (T0, 8.2 ± 4.9 vs 6.1 ± 4.0; T1, 6.6 ± 4.8 vs 3.8 ± 3.4; T24, 5.3 ± 4.5 vs 2.0 ± 2.3 [all P < .001]). These data were confirmed after the exclusion of the subjects who underwent NIV as the ceiling treatment (T0, 8.2 ± 4.9 vs 6.1 ± 4.0 [P = .002]; T1, 6.6 ± 4.8 vs 3.8 ± 3.4; T24, 5.3 ± 4.5 vs 2.0 ± 3.2 [all P < .001]). At T24, an HACOR score > 5 (Relative Risk [RR] 2.39, 95% CI 1.60–3.56) was associated with an increased mortality rate, independent of age and the Sequential Organ Failure Assessment score. CONCLUSIONS: Among the subjects treated with NIV for acute respiratory failure, the HACOR score seemed to be a useful tool to identify those at risk of in-hospital mortality.
Biodegradable engineered fiber scaffolds fabricated by electrospinning for periodontal tissue regeneration

Considering the specificity of periodontium and the unique advantages of electrospinning, this technology has been used to fabricate biodegradable tissue engineering materials for functional periodontal regeneration. For better biomedical quality, a continuous technological progress of electrospinning has been performed. Based on property of materials (natural, synthetic or composites) and additive novel methods (drug loading, surface modification, structure adjustment or 3 D technique), various novel membranes and scaffolds that could not only relief inflammation but also influence the biological behaviors of cells have been fabricated to achieve more effective periodontal regeneration. This review provides an overview of the usage of electrospinning materials in treatments of periodontitis, in order to get to know the existing research situation and find treatment breakthroughs of the periodontal diseases.
Assessment of Augmented Reality in Manual Wiring Production Process with Use of Mobile AR Glasses

Digitalization of production environment, also called Industry 4.0 (the term invented by Wahlster Wolfgang in Germany) is now one of the hottest topics in the computer science departments at universities and companies. One of the most significant topics in this area is augmented reality (AR). The interest in AR has grown especially after the introduction of the Microsoft HoloLens in 2016, which made this technology available for researchers and developers all around the world. It is divided into numerous subtopics and technologies. These wireless, see-through glasses give a very natural human-machine interface, with the possibility to present certain necessary information right in front of the user’s eyes as 3D virtual objects, in parallel with the observation of the real world, and the possibility to communicate with the system by simple gestures and speech. Scientists noted that in-depth studies connected to the effects of AR applications are presently sparse. In the first part of this paper, the authors recall the research from 2019 about the new method of manual wiring support with the AR glasses. In the second part, the study (tests) for this method carried out by the research team is described. The method was applied in the actual production environment with consideration of the actual production process, which is manual wiring of the industrial enclosures (control cabinets). Finally, authors deliberate on conclusions, technology’s imperfections, limitations, and future possible development of the presented solution.