Miracle-dz/UniFAR-FTUs huggingface dataset:
Differential moderation effects of ApoE and 5-HTTLPR genotypes on social vulnerability in predicting mortality among community-dwelling middle-aged and older adults: a nationwide population-based study

Aging is a dynamic complex process involving social vulnerability over time. The social vulnerability index (SVI) was developed that predicted adverse health outcomes. This study examined effects between SVI status and two genotypes, apolipoprotein E (ApoE) and Serotonin transporter genotyping (5-HTTLPR), on all-cause mortality. Data from the Social Environment and Biomarkers of Aging Study (SEBAS) were obtained, and SVI was constructed using 32 self-reported items of social determinants. Data from 985 participants (age: 65.73 ± 9.47 years, 54.62% males) were obtained for analysis, and the median SVI was 0.35 (IQR 0.29–0.42) with a near normal distribution. Participants with a higher SVI were more likely to be women and have poor cognitive function, more depressive symptoms and poor physical function. Adjusted for age and sex, each incremental deficit in SVI was associated with a 12% increase in mortality risk (HR: 1.12, 95% CI: 1.04–1.20, p = 0.002). An interaction was found between ApoE and SVI but not 5-HTTLPR. The strata-specific hazard ratio confirmed that associations between SVI and mortality was only in non-ε4 carriers (HR: 1.15, 95% CI: 1.07–1.24, p < 0.001), and SVI did not significantly predict mortality among ε4 carriers (HR: 0.84, 95% CI: 0.65–1.10). Differential SVI effects on mortality among middle-age and older adults were identified. In conclusion, a higher SVI was associated with all-cause mortality among middle-aged and older adults, and the association was moderated by ApoE genotypes but not 5-HTTLPR. Further study is needed to evaluate the clinical efficacy of healthy aging intervention programs considering gene-environment interactions and social vulnerability.
Comparison of the registration process of the medicines control authority of Zimbabwe with Australia, Canada, Singapore, and Switzerland: benchmarking best practices

ABSTRACT Background Benchmarking regulatory systems of low- and middle-income countries with mature systems provides an opportunity to identify gaps, enhance review quality, and reduce registration timelines, thereby improving patients’ access to medicines. The aim of this study was to compare the medicines registration process of the Medicines Control Authority of Zimbabwe (MCAZ) with the regulatory processes in Australia, Canada, Singapore, and Switzerland. Methods A questionnaire that standardizes the review process, allowing key milestones, activities and practices of the five regulatory authorities was completed by a senior member of the divisions responsible for issuing marketing authorizations. Results The MCAZ has far fewer resources than the regulatory authorities in the comparator countries, but employs three review models, which is in line with international best practice. The MCAZ registration process is similar to the comparator countries in key milestones monitored, but differs in the target timelines for these milestones. The MCAZ is comparable to the comparator authorities in implementing the majority of good review practices, although it significantly lags behind in transparency and communication. Conclusion This study identified the MCAZ strengths and opportunities for improvement, which if implemented, will enable the achievement of its vision to be a leading regulatory authority in Africa.
Agustín González, an Inspirational Leader in Spanish Comparative Neuroanatomy

a Centre for Developmental Neurobiology, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK; b MRC Centre for Neurodevelopmental Disorders, King’s College London, London, UK; c Departamento de Biología Celular, Facultad de Biología, Universidad Complutense de Madrid, Madrid, Spain Received: July 15, 2021 Accepted: August 14, 2021 Published online: October 13, 2021
Association of PTTG1 expression with invasiveness of non-functioning pituitary adenomas

Background Pituitary tumor transforming gene 1 (PTTG1), paired-like homeodomain 2 (PITX2), and galectin-3 have been widely studied as predictive biomarkers for various tumors and are involved in tumorigenesis and tumor progression. We evaluated the usefulness of PTTG1, PITX2, and galectin-3 as predictive biomarkers for invasive non-functioning pituitary adenomas (NFPAs) by determining the relationship between the expressions of these three proteins and the invasiveness of the NFPAs. We also investigated whether PTTG1, E-cadherin, and Ki-67, which are known to be related to each other, show a correlation with NFPA features. Methods A retrospective study was conducted on 87 patients with NPFAs who underwent surgical removal. The NFPAs were classified into three groups based on magnetic resonance imaging findings of suprasellar extension and cavernous sinus invasion. Immunohistochemical staining for PTTG1, PITX2, galectin-3, E-cadherin, and Ki-67 was performed on tissue microarrays. Results PTTG1 expression showed a statistically significant correlation with the invasiveness of NFPAs, whereas PITX2 and galectin-3 did not have a relationship with the invasiveness of NFPAs. Moreover, there was no association among PTTG1, E-cadherin, and Ki-67 expression. Conclusions PTTG1 has the potential to serve as a predictive biomarker for invasive NFPA. Furthermore, this study may serve as a reference for the development of PTTG1-targeted therapeutic agents.
Passive leg movement: A novel method to assess vascular function during passive leg heating?

Over the last decade, passive leg movement (PLM) has emerged as an increasingly popular alternative to flow-mediated dilatation (FMD) for the non-invasive assessment of vascular endothelial function. Passive leg movement involves continuous measurement of common femoral artery (CFA) blood flow (BF) by Doppler ultrasound as the participant’s leg is passively extended and flexed at a fixed rate (60 movements/min) for 1–2 min. The assessment is based on the notion that the mechanical deformation of vessels caused by the movement stimulates a predominantly nitric oxide (NO)-mediated vasodilatory response (Mortensen et al., 2012), the magnitude of which is believed to be indicative of vascular endothelial function. Despite a growing appreciation of the many potential benefits of this new, easy-to-administer and non-invasive technique, many questions remain unanswered regarding the optimization of the method and the interpretation of the results. In the October issue of Experimental Physiology, Shields et al. (2021) used local passive leg heating to investigate the extent to which differences in baseline BF might impact estimates of vascular function measured during PLM. Although the authors are to be commended for a well-planned and carefully executed study, their paper (as is often the case in newly burgeoning fields of research) introduced as many exciting new research questions as it answered. As far as their primary aim was concerned, their results are clear: at high levels of baseline BF (in this case, almost double normal resting values) PLM responses are affected, with the overall peak BF response found to be greater (∼100 ml/min), but relative changes from baseline (BFΔpeak) smaller. Thus, they draw the reasonable conclusion that taking care to obtain true baseline BF values before conducting PLM is paramount to the reliability of this technique. A welcome bonus to using a local passive
Informal caregiving during the COVID-19 pandemic: findings from a representative, population-based study during the second wave of the pandemic in Germany

Abstract Objectives This study investigates how the COVID-19 pandemic has affected the informal caregiving situation in terms of prevalence of caregivers, infection rates, perception of impairment and danger by the pandemic, and changes in the caregiving performance among long-term caregivers from before to during the peak of the pandemic. Methods Informal caregivers (N = 489 during the pandemic) from a population-based sample, representative for individuals aged ≥40 years from Germany (N = 3022, assessed March 2021), were questioned. Sociodemographic information, prevalence and performance of informal care before and during the second pandemic wave, infection rates and perceived impairment and danger of the pandemic were assessed. Results Results indicate no significantly different prevalence of informal caregiving during the pandemic compared to before. Few caregivers and few of their care recipients were infected. Overall, a low to moderate level of impairment was reported by caregivers, but a moderately high perceived danger, particularly for care recipients. Among long-term caregivers, caregiving intensity and time increased during the pandemic, less ambulatory care but more shopping help was used and care task distribution and use of support changed. Conclusion While the prevalence of informal caregivers remained unchanged, the caregiving situation worsened among long-term caregivers. Infection rates among caregivers were low, but they perceived themselves and their care recipients to be endangered. Future research and policy should focus more on this vulnerable group during a health crisis, primarily on long-term caregivers, in order to effectively support them in their care provision for the high risk group of older care recipients.
Outcomes of older patients aged 60 to 70 years undergoing reduced intensity transplant for acute myeloblastic leukemia: results of the NCRI acute myeloid leukemia 16 trial

Reduced intensity conditioning (RIC) transplantation is increasingly offered to older patients with acute myeloblastic leukemia. We have previously shown that a RIC allograft, particularly from a sibling donor, is beneficial in intermediate-risk patients aged 35-65 years. We here present analyses from the NCRI AML16 trial extending this experience to older patients aged 60-70 inclusive lacking favorable-risk cytogenetics. Nine hundred thirty-two patients were studied, with RIC transplant in first remission given to 144 (sibling n=52, matched unrelated donor n=92) with a median follow-up for survival from complete remission of 60 months. Comparisons of outcomes of patients transplanted versus those not were carried out using Mantel-Byar analysis. Among the 144 allografted patients, 93 had intermediate-risk cytogenetics, 18 had adverse risk and cytogenetic risk group was unknown for 33. In transplanted patients survival was 37% at 5 years, and while the survival for recipients of grafts from siblings (44%) was better than that for recipients of grafts from matched unrelated donors (34%), this difference was not statistically significant (P=0.2). When comparing RIC versus chemotherapy, survival of patients treated with the former was significantly improved (37% versus 20%, hazard ratio = 0.67 [0.53-0.84]; P<0.001). When stratified by Wheatley risk group into good, standard and poor risk there was consistent benefit for RIC across risk groups. When stratified by minimal residual disease status after course 1, there was consistent benefit for allografting. The benefit for RIC was seen in patients with a FLT3 ITD or NPM1 mutation with no evidence of a differential effect by genotype. We conclude that RIC transplantation is an attractive option for older patients with acute myeloblastic leukemia lacking favorable-risk cytogenetics and, in this study, we could not find a group that did not benefit.
Influenza vaccine and risk of acute myocardial infarction in a population-based case–control study

Objective To assess the relationship between influenza vaccination and risk of a first acute myocardial infarction (AMI) in the general population by different epidemic periods. Methods This is a population-based case–control study carried out in BIFAP (Base de datos para la investigación farmacoepidemiológica en atención primaria), over 2001–2015, in patients aged 40–99 years. Per each incident AMI case, five controls were randomly selected, individually matched for exact age, sex and index date (AMI diagnosis). A patient was considered vaccinated when he/she had a recorded influenza vaccination at least 14 days before the index date within the same season. The association between influenza vaccination and AMI risk was assessed through a conditional logistic regression, computing adjusted ORs (AOR) and their respective 95% CIs. The analysis was performed overall and by each of the three time epidemic periods per study year (pre-epidemic, epidemic and postepidemic). Results We identified 24 155 AMI cases and 120 775 matched controls. Of them, 31.4% and 31.2%, respectively, were vaccinated, yielding an AOR of 0.85 (95% CI 0.82 to 0.88). No effect modification by sex, age and background cardiovascular risk was observed. The reduced risk of AMI was observed shortly after vaccination and persisted over time. Similar results were obtained during the pre-epidemic (AOR=0.87; 95% CI 0.79 to 0.95), epidemic (AOR=0.89; 95% CI 0.82 to 0.96) and postepidemic (AOR=0.83; 95% CI 0.79 to 0.87) periods. No association was found with pneumococcal vaccine (AOR=1.10; 95% CI 1.06 to 1.15). Conclusions Results are compatible with a moderate protective effect of influenza vaccine on AMI in the general population, mostly in primary prevention, although bias due to unmeasured confounders may partly account for the results.
Built to last: gene therapy for ADA SCID.

6. Cercamondi CI, Egli IM, Ahouandjinou E, et al. Afebrile Plasmodium falciparum parasitemia decreases absorption of fortification iron but does not affect systemic iron utilization: a double stable-isotope study in young Beninese women. Am J Clin Nutr. 2010;92(6): 1385-1392. 7. Pasricha SR, Armitage AE, Prentice AM, Drakesmith H. Reducing anaemia in low income countries: control of infection is essential. BMJ. 2018;362:k3165.
Predicting photovoltaic soiling losses using environmental parameters: An update

This study presents an investigation on the correlations between soiling losses and environmental parameters at 41 locations in the United States, with the aim of analyzing the possibility of predicting soiling losses at a site even when soiling data are not available. The results of this work, which considers the largest pool of soiling data points systematically investigated so far, confirm that a single‐variable regression based on particulate matter concentration returns the best correlations with soiling, with adjusted coefficients of determination up to 70%, corresponding to RMSE as low as 0.9%. Among the various particulate matter datasets investigated, a gridded Environment Protection Agency dataset is for the first time found to return correlations similar to those obtained by interpolating particulate matter monitoring station data. We discuss in detail the different interpolation techniques used to process the particulate matter concentrations because they can greatly impact the correlations. Specifically, the correlation coefficients between soiling and particulate matter range between 70% and less than 20%, depending on the interpolation methods and monitoring distance. Spatial interpolation methods based on inverse distance weighting are found to return better correlations than a nearest neighbor or a simple average approach, especially when large distances are considered. Similarly, the effects of different rain thresholds used to calculate the length of the dry periods are examined. An enhanced two‐variable regression is found to achieve higher‐quality correlations, with adjusted R2 of 90% (RMSE = 0.55%), also suggesting that high and low soiling locations might be differentiated depending on fixed particulate matter or rainfall thresholds.
Increasing the Durability of Polymer Electrolyte Membranes Using Organic Additives

Herein, we utilize organic radical scavengers to mitigate the chemical degradation of polymer membranes without sacrificing their proton conductivity. Several hydrocarbon composite membranes based on sulfonated poly(arylene ether sulfone) (SPES50, degree of sulfonation = 50%) and containing organic radical scavengers were prepared and characterized in terms of water uptake, ion-exchange capacity, proton conductivity, and oxidative stability, being additionally exposed to hydrogen peroxide for accelerated oxidative stability testing. Precise analysis of the molecular weight and its distribution before and after the above test confirmed that the incorporation of radical scavengers enhanced the chemical durability of membranes while maintaining their proton conductivity. Finally, in an accelerated open circuit voltage durability test, composite membranes showed lifetimes exceeding 1400 h, whereas pristine SPES50 failed after 750 h. On the basis of the above, organic radical scavengers were concluded to be superior to those based on transition-metal compounds, not engaging in any interactions with the sulfonate groups of the membrane polymer and hence not compromising their proton conductivity.
Effects of brief substance use interventions delivered in general medical settings: a systematic review and meta-analysis.

AIMS To estimate effects of brief substance use interventions delivered in general medical settings. METHODS A systematic review and meta-analysis of randomized trials conducted since 1990 of brief substance use interventions in patients of any age or severity level recruited in general medical settings. Primary outcomes were any measure of substance use or substance-related consequences (indexed with Hedges' g and risk ratios). Mixed-effects meta-regressions were used to estimate overall effects and predictors of effect variability. Analyses were conducted separately by brief intervention (BI) target substance: alcohol only or drugs. FINDINGS A total of 116 trials (64 439 participants) were identified; 111 (62 263 participants) provided effect size data and were included in the meta-analysis. Drug-targeted BIs yielded significant small improvements in multiple drug/mixed substance use (Hedges' g ( g ¯ ) = 0.08; 95% CI = 0.002, 0.15), but after adjusting for multiple comparisons, they did not produce significant effects on cannabis use ( g ¯ = 0.06; 95% CI = 0.001, 0.12), alcohol use ( g ¯ = 0.08; 95% CI = -0.0003, 0.17), or consequences ( g ¯ = 0.05; 95% CI = 0.01, 0.10). Drug-targeted BIs yielded larger improvements in multiple drug/mixed substance use when delivered by a general practitioner ( g ¯ = 0.19; 95% CI = 0.187, 0.193). Alcohol-targeted BIs yielded small beneficial effects on alcohol use ( g ¯ = 0.12; 95% CI 0.08, 0.16), but no evidence of an effect on consequences ( g ¯ = 0.05; 95% CI = -0.04, 0.13). However, alcohol-targeted BIs only had beneficial effects on alcohol use when delivered in general medical settings ( g ¯ = 0.17; 95% CI = 0.10, 0.24); the findings were inconclusive for those delivered in emergency department/trauma centers ( g ¯ = 0.05; 95% CI = 0.00, 0.10). CONCLUSIONS When delivered in general medical settings, alcohol-targeted brief interventions may produce small beneficial reductions in drinking (equivalent to a reduction in 1 drinking day per month). There is limited evidence regarding the effects of drug-targeted brief interventions on drug use.
Epidemiology and treatment status of hepatitis C virus infection among people who have ever injected drugs in Korea: a prospective multicenter cohort study from 2007 to 2019 in comparison with non-PWID

OBJECTIVES Injection drug use is a major risk factor for hepatitis C virus (HCV) infection; however, limited data on this topic are available in Korea. Thus, this study aimed to investigate the epidemiological and clinical characteristics, treatment uptake, and outcomes of HCV infection among people who inject drugs (PWID). METHODS We used the data from the Korea HCV cohort, which prospectively enrolled patients with HCV infection between 2007 and 2019. Clinical data and results of a questionnaire survey on lifetime risk factors for HCV infection were analyzed according to a self-reported history of injection drug use (PWID vs. non-PWID group). RESULTS Among the 2,468 patients, 166 (6.7%) were in the PWID group, which contained younger patients (50.6±8.2 vs. 58.2±13.1 years) and a higher proportion of male (81.9 vs. 48.8%) than the non-PWID group. The distribution of PWID showed significant regional variations. Exposure to other risk factors for HCV infection was different between the groups. The proportion of patients with genotype non-2 infection was higher in the PWID group. Treatment uptake was higher in the PWID group in the interferon era; however, it was comparable between the groups in the direct-acting antiviral era. The rate of sustained virological response did not significantly differ between the groups. CONCLUSIONS As of 2019, PWID constituted a minority of HCV-infected people in Korea. The epidemiological characteristics, but not treatment uptake and outcomes, were different between the PWID and non-PWID groups. Therefore, active HCV screening and treatment should be offered to PWID in Korea.
An eye-tracking study examining the relationship between males’ eating disorder symptomatology, body mass index, and expectations about character behaviour in text

ABSTRACT Eating disorder prevalence is increasing in males, perhaps more rapidly than in females. Theorists have proposed that cognitive biases are important factors underpinning disordered eating, especially those related to food, body, and perfectionism. We investigated these factors in relation to males’ eating disorder symptomatology in the general population by using eye-tracking during reading as a novel and implicit measure. 180 males’ eye movements were monitored while they read scenarios (third-person in Experiment 1 (n = 90, 18-38(Mage = 21.50, SD = 3.65)); second-person in Experiment 2 (n = 90, 18–35(Mage = 20.50, SD = 2.22))) describing characters’ emotional responses (e.g. upset) to food-, body image-, and perfectionism-related events. Participants’ eating disorder symptomatology was then assessed, and body mass index (BMI) was calculated. Results showed processing of characters’ emotional responses (detected via eye-tracking) to body- and perfectionism-related events for third-person scenarios was related to eating disorder symptomatology. Processing of characters’ emotional responses to body-related events for second-person scenarios was related to males’ BMI. The moment-to-moment processing of characters’ emotional responses to food-related scenarios was not related to eating disorder symptomatology or BMI. Findings support theories that include body- and perfectionism-related cognitive biases as underlying mechanisms of eating disorder symptomatology and the use of implicit measures of cognitive processes underlying males’ eating disorder symptomatology.