Miracle-dz/UniFAR-FTUs huggingface dataset:
Genetic and Chemical Capsid Modifications of Adenovirus Vectors to Modulate Vector–Host Interactions

Adenovirus-based vectors are playing an important role as efficacious genetic vaccines to fight the current COVID-19 pandemic. Furthermore, they have an enormous potential as oncolytic vectors for virotherapy and as vectors for classic gene therapy. However, numerous vector–host interactions on a cellular and noncellular level, including specific components of the immune system, must be modulated in order to generate safe and efficacious vectors for virotherapy or classic gene therapy. Importantly, the current widespread use of Ad vectors as vaccines against COVID-19 will induce antivector immunity in many humans. This requires the development of strategies and techniques to enable Ad-based vectors to evade pre-existing immunity. In this review article, we discuss the current status of genetic and chemical capsid modifications as means to modulate the vector–host interactions of Ad-based vectors.
Welfare-Improving Mixed Collusion

We study collusion between a public firm and a private firm, focusing on the impact of the public firm’s preference for consumer surplus. We characterize the collusive outcome (market shares, profits, consumer surplus and welfare) that results from Nash bargaining between the two firms, compare it with the competitive outcome, and study sustainability of collusion. If the public firm’s preference for consumer surplus is mild, collusive outcomes are qualitatively similar to those of a private duopoly (both firms reduce output) although distorted by the public firm’s bias towards high output. If the public firm’s preference for consumer surplus is strong, the collusive outcome is qualitatively different. While the public firm reduces output, the private firm expands output to such an extent that total output increases (as long as the public firm’s preference for consumer surplus is not excessive). Output is transferred from the public firm to the private firm so that productive efficiency increases, resulting in higher profits and welfare.
ORAL POSTER REFERENCE : ICF100966OR

Composites are heterogeneous materials. Brittle matrix composites combine brittle constituents. As a consequence, damage and failure exhibit typical features that influence the response under load. A large amount of data on the mechanical behavior of unidirectionnally reinforced ceramic matrix composites can be found in the literature. The present paper examines the ultimate failure and damage mechanisms in 2D woven SiC/SiC composites. The failure mechanisms as well as features of ultimate failure are addressed. In particular, it is emphasized that ultimate failure and matrix damage are successive and separate phenomena and that the statistical distribution of strength data exhibit a limited scatter and a very limited dependence on the stressed volume.
Differential Endometrial Responses of Primates vs Rodents: Screening for Antiproliferative Effects of Antiprogestins

DIFFERENTIAL ENDOMETRIAL RESPONSES OF PRIMATES VS RODENTS: SCREENING FOR ANTIPROLIFERATIVE EFFECTS OF ANTIPROGESTINS David Williams Burleigh Eastern Virginia Medical School and Old Dominion University, 1997 Director D r Gary D. Hodgen The antiprogestin, mifepristone, has previously been shown to noncompetitively inhibit estrogen-induced endometrial proliferation in nonhuman primates (van Uem et al., 1989; Wolf et al., 1989b; Neulen et al., 1990; Neulen et al., 1996). For both economical and ethical reasons, we are encouraged to identify comparative laboratory rodent models which can substitute the need to use primate models. In the following study, we compared capabilities of the rat uterine weight bioassay versus a primate uterine bioassay, to identify the noncompetitive antiestrogenic/antiproliferative effects of mifepristone. Long-term ovariectomized monkeys were exposed to exogenous l7|3-estradiol (E2) and mifepristone in doses and regimes already demonstrated to curtail endometrial growth (Wolf et al., 1989b). Results show that mifepristone decreased endometrial proliferation in a dose-dependent manner, and this decrease occurred in the presence of physiologic serum E2 levels. In the rat model, ovariectomized immature (day 20) and adult Sprague-Dawley rats were pretreated with E2 for 3 days, followed by E2 plus mifepristone (various doses) for 3 additional days. E2 replacement was either given as 0.5 pg/100 g body weight (in oil, sc) or as a 0.5 mg sc pellet. Mifepristone did not induce a decrease in uterine wet or blotted weights in immature or adult rats receiving E2 replacement as 0.5 pg/100 g body weight (P>0.05). This lack of effect was not due to insufficient E2 stimulation as histological evaluation of the endometrium showed increased numbers of mitotic figures in all treatment groups and serum E2 levels were in the diestrous-proestrous range. In contrast, mifepristone did inhibit an increase in uterine wet weight of adult rats (P<0.05) R eproduced with perm ission of the copyright owner. Further reproduction prohibited without perm ission. and immature rats (P<0.01) receiving E2 replacement as O.S mg E2 pellet. Uterine blotted weights were also effected by treatment with mifepristone in the immature rats (P<0.05). Serum E2 levels attained in rats given the O.S mg E2 pellet were pharmacological (>800 pg/ml), illustrating a relationship between E2 levels and capability of mifepristone to affect rat uterine weight. Based on the results summarized here, we do not recommend using the rat uterine weight bioassay as a substitute model for screening antiprogestins for noncompetitive antiestrogenic/antiproliferative effects on primate uterine endometrium. R eproduced with perm ission of the copyright owner. Further reproduction prohibited without perm ission.
Correlation between Job Motivation, Job Satisfaction, and Perceived Organizational Support with Organizational Citizenship Behavior (OCB)

This paper is a review study which focus to discuss the correlation between job motivation, job satisfaction, and perceived organizational support (POS) with OCB. This type of research is explanatory research, using literature review design to determine the relationship between job motivation, job satisfaction, and POS, toward the Oranizational Citizenship Behavior (OCB). The results found that job motivation, job satisfaction, and perceived organizational support had a positive and significant correlation on employees’ OCB. In order to start an integrated discipline, the findings of this analysis are just a conceptual starting point.
Rekindling Action Language: A Neuromodulatory Study on Parkinson’s Disease Patients

Impairments of action semantics (a cognitive domain that critically engages motor brain networks) are pervasive in early Parkinson’s disease (PD). However, no study has examined whether action semantic skills in persons with this disease can be influenced by non-invasive neuromodulation. Here, we recruited 22 PD patients and performed a five-day randomized, blinded, sham-controlled study to assess whether anodal transcranial direct current stimulation (atDCS) over the primary motor cortex, combined with cognitive training, can boost action–concept processing. On day 1, participants completed a picture–word association (PWA) task involving action-verb and object-noun conditions. They were then randomly assigned to either an atDCS (n = 11, 2 mA for 20 m) or a sham tDCS (n = 11, 2 mA for 30 s) group and performed an online PWA practice over three days. On day 5, they repeated the initial protocol. Relative to sham tDCS, the atDCS group exhibited faster reaction times for action (as opposed to object) concepts in the post-stimulation test. This result was exclusive to the atDCS group and held irrespective of the subjects’ cognitive, executive, and motor skills, further attesting to its specificity. Our findings suggest that action-concept deficits in PD are distinctively grounded in motor networks and might be countered by direct neuromodulation of such circuits. Moreover, they provide new evidence for neurosemantic models and inform a thriving agenda in the embodied cognition framework.
VOICE ONSET TIME IN MULTILINGUAL SPEAKERS: ITALIAN HERITAGE SPEAKERS IN GERMANY WITH L3 ENGLISH

Abstract This study brings together two previously largely independent fields of multilingual language acquisition: heritage language and third language (L3) acquisition. We investigate the production of fortis and lenis stops in semi-naturalistic speech in the three languages of 20 heritage speakers (HSs) of Italian with German as a majority language and English as L3. The study aims to identify the extent to which the HSs produce distinct values across all three languages, or whether crosslinguistic influence (CLI) occurs. To this end, we compare the HSs’ voice onset time (VOT) values with those of L2 English speakers from Italy and Germany. The language triad exhibits overlapping and distinct VOT realizations, making VOT a potentially vulnerable category. Results indicate CLI from German into Italian, although a systemic difference is maintained. When speaking English, the HSs show an advantage over the Italian L2 control group, with less prevoicing and longer fortis stops, indicating a specific bilingual advantage.
Running title: CHANGES IN CLIMATE EXTREMES IN VIÇOSA-MG Academy Section: ENGINEERING SCIENCES

Extreme climatic events and their hazards have strong impact on society. Urban areas in Brazil are especially vulnerable to the impact of such events due to their rapid growth and inappropriate infrastructure. Viçosa is a mid-sized city in Southeastern Brazil that has been experiencing issues associated with urban expansion and population growth since the 1960s. Thus, this study aims to identify patterns of extreme climate events in Viçosa based on daily temperature and precipitation time series (1968-2017). Homogeneity tests were carried out in order to identify breaking points in these climate variables. Climate trends were analyzed through Mann-Kendall test and their magnitude was checked based on Sen’s slope. Results have evidenced statistically signifi cant and increasing trends in annual minimum temperature since the 1990s. Moreover, statistically signifi cant breaking points in extreme temperature indices have shown increasing number of warm days, and decreasing number of cold nights, in both annual and seasonal analyses. Extreme climatic events have been observed more often in recent years, mainly in the number of consecutive dry days and maximum and heavy precipitation days. Based on results, Viçosa experiences warmer conditions throughout the year, whereas more (less) torrential rainfall events have been occurring during Summer (Winter).
Stock Returns Predictable: Some New Evidence from the Korean Stock Market

This paper makes three contributions to the literature on predictability stock returns in the Korean stock market. We focus on out-of-sample forecasting of returns based on industry portfolios are predictability. From the results, we discover that in-sample and out-of-sample test during from 2000 to 2015, predictability is not homogeneous. Furthermore, we examine the determinants of out-of-sample predictability for each sector using industry characteristics and find strong evidence that return predictability has links to certain industry characteristics, such as book-to-market ratio, dividend yield, size, price earnings ratio, and trading volume. We also discover a mean combination forecast approach which has significant out-of-sample performance.
IMPLICATIONS OF CORPORATE SOCIAL RESPONSIBILITY ON CREDIT RATING: A CONTEXT OF DEVELOPING ECONOMY

This study wants to explore the implications of corporate social responsibility on credit system rating in non-financial corporations of a developing country. Ordered probit regression model has been implementing for data analysis for a sample period of 2013-2019. This data analysis distributed in three phases, overall analysis, initial and ending analysis because of data availability. Firstly, descriptive statistics showed normality of data and correlation statistics indicated a relationship between corporate social responsibilities as independent variable, credit rating and a group of control variables. In all three phases, corporate social responsibility is significantly and positively contributing to the systematic determination of credit rating of organizations and control variables are showing some deviating results. These significant positive results of CSR on credit ratings suggest that by increasing a firm’s credit rating, investment in CSR activities is likely to increase the firm value and shareholders’ value. Credit rating agencies tend to grant moderately high appraisals to firms who appreciate the great social performance. Discoveries of this study will help administrators and also financial specialists to better comprehend the impact of CSR using a loan evaluations and credit ratings.
Aberystwyth University Weight selection strategies for ordered weighted average based fuzzy rough sets

Fuzzy rough set theory models both vagueness and indiscernibility in data, which makes it a very useful tool for application to various machine learning tasks. In this paper, we focus on one of its robust generalisations, namely ordered weighted average based fuzzy rough sets. This model uses a weighted approach in the definition of the fuzzy rough operators. Although its efficacy and competitiveness with state-of-the-art machine learning approaches has been well established in several studies, its main drawback is the difficulty in choosing an appropriate weighting scheme. Several options exist and an adequate choice can greatly enhance the suitability of the ordered weighted average based fuzzy rough operators. In this work, we develop a clear strategy for the weighting scheme selection based upon the underlying characteristics of the data. The advantages of the approach are presented in a detailed experimental study. Rather than to propose a classifier, our aim is to present a strategy to select a suitable weighting scheme for ordered weighted average based fuzzy rough sets in general. Our weighting scheme selection process allows users to take full advantage of the versatility offered by this model and performance improvements over the traditional fuzzy rough set approaches. ∗Corresponding author Email address: Chris.Cornelis@UGent.be (Chris Cornelis) Preprint submitted to Information Sciences December 17, 2018 *Manuscript (including abstract) Click here to view linked References
Smart buildings Cooling and Heating Load Forecasting Models: Review

The proper implementation of the building cooling and heating load prediction models is a key factor to enhance the energy efficiency buildings usage. In the recent years, a number of researches conducted to forecast the cooling and heating loads. Most challenging and significant parts of prediction are determining the most efficient input parameters and develop a high accuracy prediction models. Several data-driven prediction models are proposed to develop the best control of the energy consumption systems, while provide a suitable indoor comfort environment. Despite of the number of review articles discussed the advantage and disadvantages of prediction models, there are gaps in reviewing cooling and heating load prediction models. This study provides a critical review of recent models used in cooling and heating load prediction by focusing on model performance and accuracy. The comparative analysis of the review shows that each prediction model has particular advantages in comparison to other models. Additionally, the review comes out with that most of the models has shortcomings from the parameters considered as input, and the techniques used to implement the models. The aim of this review is to highlight the disadvantages of existing models used in the cooling and heating load predictions and provide a comparative analysis of these techniques.
Post-vaccination SARS-COV-2 among healthcare workers in New Jersey : a genomic 1 epidemiological study 2 3 4

Post-vaccination SARS-COV-2 among healthcare workers in New Jersey: a genomic 1 epidemiological study 2 3 4 Barun Mathema, Liang Chen, Kar Fai Chow, Yanan Zhao, Michael C Zody, Jose R 5 Mediavilla, Marcus H Cunningham, Kaelea Composto, Annie Lee, Dayna M Oschwald, 6 Soren Germer, Samantha Fennessey, Kishan Patel, David Wilson, Ann Cassell, Lauren 7 Pascual, Andrew Ip, André Corvelo, Sophia Dar, Yael Kramer, Tom Maniatis, David S 8 Perlin, Barry N Kreiswirth 9 10 1. Mailman School of Public Health, Columbia University Irving Medical Center, New York, 11 NY, USA 12 2. Hackensack Meridian Health Center for Discovery and Innovation, Nutley, NJ, USA 13 3. Hackensack Meridian School of Medicine, Nutley, NJ 07110, USA 14 4. Hackensack Meridian Health Biorepository, Hackensack, NJ. USA 15 5. New York Genome Center, New York, NY, USA 16 6. Hackensack Meridian Health BI Analytics, Edison, NJ, USA 17 7. John Theurer Cancer Center, Outcomes Division, Hackensack University Medical 18 Center, Hackensack, NJ, USA. 19 20 a Barun Mathema and Liang Chen contributed equally to this article. The order of co-first authors 21 was determined by discussion and mutual agreement between the two co-first authors. 22 23 *Correspondence to: Dr. Barry N Kreiswirth, Barry.Kreiswirth@hmh-cdi.org 24 25 Running title: Post-vaccination COVID-19 in New Jersey 26 . CC-BY-NC-ND 4.0 International license It is made available under a is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. (which was not certified by peer review) The copyright holder for this preprint this version posted July 5, 2021. ; https://doi.org/10.1101/2021.06. 30.21259761 doi: medRxiv preprint
Cash Holding and Firm Value in the Presence of Managerial Optimism

Cash holding is important for Chinese manufacturing firms coping with the increasing cost of financing and stiff market conditions. This study examines the impact of cash holding on the firm value of Chinese manufacturing firms. We find evidence that a non-linear relationship exists between cash holding and firm value in manufacturing firms of China. The study reveals that financially constrained firms having a higher level of cash holding negatively affects the firm value, while the unconstrained firms having a lower level of cash holding positively influences the firm value. Finally, this research is enriched by adopting the novel measure of managerial op-timism and reveals the interactive role of cash holding and optimism on firm value. The study concludes that managerial optimism influences the firm’s cash holding decisions and this is more costly for unconstrained firms.
Vibrations of bars including transverse shear deformations and warping due to torsion

The paper deals with coupled flexural-torsional vibrations of straight prismatic elastic bars made of a linearly elastic isotropic and homogeneous material. One of the aims is to develop an effective method of modelling vibrations of train rails of cross-sections being mono-symmetric, taking into account warping due to torsion as well as transverse shear deformations. The Librescu-Song 1D model has been appropriately adapted to the above research aims by incorporating all the inertia terms corresponding to the kinematic hypotheses. The finite element(FE) program has been written and its correctness has been verified. The results concerning natural vibrations compare favourably with those predicted by 3D FE modelling using dense meshes. The paper proves that neglecting warping due to torsion leads to omitting several eigen-modes of vibrations, thus showing that the popular Timoshenko-like models are useless for the vibration analysis of bars of mono-symmetric cross sections.
AIR QUALITY EDUCATION IN ANIMAL AGRICULTURE Mitigation Strategies : Additives November 2011 1

Figure 1. A system designed to evaluate different dosages of an additive in a lagoon. North Carolina is the second largest producer of hogs in the United States, with an on-farm inventory of 9.5 million animals in December 2006. These hogs are mostly raised over shallow pits (18 to 24 inches deep) on slatted floors. Hog urine and feces, spilled feed, and water collected in the pits are periodically emptied into an anaerobic (absence of air or oxygen) lagoon. In the lagoon, anaerobic bacteria break down the organic material into sim pler organic and inorganic compounds. However, during this process, organic gas es (also called volatile organic compounds or VOCs) and inorganic gases (e.g., am monia, hydrogen sulfide) are produced. Many of these gases, individually or in combination, produce objectionable odors. Schiffman and others (2001) identified 331 VOCs in hog barn air and lagoon waste samples that contribute to odors.
The Return Expectations of Public Pension Funds

The return expectations of public pension funds are positively related to cross-sectional differences in past performance. This positive relation operates through the expected risk premium, rather than the expected risk-free rate or inflation rate. Pension funds act on their beliefs and adjust their portfolio composition accordingly. Persistent investment skills, risk-taking, efforts to reduce costly rebalancing, and fiscal incentives from unfunded liabilities cannot fully explain the reliance of expectations on past performance. The results are consistent with extrapolative expectations, as the dependence on past returns is greater when executives have personally experienced longer performance histories with the fund.
Job Crafting and Employee Innovation: The Role of Work Engagement

Job crafting – a self-initiated strategy employees utilize to revise and make their jobs more meaningful is associated with beneficial outcomes. However, an important individual outcome variable, which has the potential to sustain the competitive advantage of organizations, employee innovation has received less attention in the job crafting literature. The present study examined a cross-lagged model, examining the extent to which facets of work engagement moderate job crafting-employee innovation relationship overtime. Our study involved employees working in banking organisations in Ghana. Our path analytic model indicates that innovative employees were more likely to craft their jobs, but the converse was not true; and innovation was associated with more job crafting for highly absorbed employees. We have presented the theoretical and practical implications of the study.