Miracle-dz/UniFAR-FTUs huggingface dataset:
APPROACHES TO ESTIMATING INDIRECT COSTS IN HEALTHCARE: MOTIVATIONS FOR CHOICE

When performing health economic evaluations all costs and expected benefits (in terms of clinical effectiveness, utility, monetary benefits) should be taken into account. Costs are direct and indirect: concerning the latter, two main methods have been developed. The Human Capital Approach (HCA) considers the gross salary in the days of absence from work due to illness; the method based on the Friction Costs (FC), instead, considers equally the value of productivity, but the losses are limited to the period of illness when it is necessary to replace the absent worker. This paper conducts a review of the literature contributions for European countries and aims at identifying common trends within geographical areas. Estimation of indirect costs in different European areas may reflect the real cost of health services across countries and schematize the conditions under which a certain method should be preferred. Overall, cost analyses applying HCA are the most frequent, while studies based on FC are more common in the Netherlands, where this method had been developed. The reasons to apply HCA or FC may depend on the institutional context, for example, the flexibility in the job market, and the epidemiologic environment.
Coronary Artery Bypass Graft Surgery Brings Better Benefits to Heart Failure Hospitalization for Patients with Severe Coronary Artery Disease and Reduced Ejection Fraction

Objectives: We compared the outcomes between percutaneous coronary intervention (PCI) and coronary artery bypass graft surgery (CABG) for revascularization in patients with reduced ejection fraction (EF) and severe coronary artery disease (CAD). Methods: Between February 2006 and February 2020, a total of 797 patients received coronary angiograms due to left ventricular EF ≤ 40% at our hospital. After excluding diagnoses of dilated cardiomyopathy, valvular heart disease, prior CABG, acute ST-segment myocardial infarction, and CAD with low Synergy between PCI with Taxus and Cardiac Surgery (SYNTAX) score (≤22), 181 patients with severe coronary artery disease (CAD) with SYNTAX score >22 underwent CABG or PCI for revascularization. Vascular characteristics as well as echocardiographic data were compared between CABG (n = 58) and PCI (n = 123) groups. Results: A younger age (62 ± 9.0 vs. 66 ± 12.1; p = 0.016), higher new EuroSCORE II (8.6 ± 7.3 vs. 3.2 ± 2.0; p < 0.001), and higher SYNTAX score (40.5 ± 9.8 vs. 35.4 ± 8.3; p < 0.001) were noted in the CABG group compared to those in the PCI group. The CABG group had a significantly higher cardiovascular mortality rate at 1-year (19.6% vs. 5.0%, p = 0.005) and 3-year (25.0% vs. 11.4%, p = 0.027) follow-ups but a lower incidence of heart failure (HF) hospitalization at 1-year (11.1% vs. 28.2%, p = 0.023) and 3-year (3.6% vs. 42.5%, p = 0.001) follow-ups compared to those of the PCI group. Conclusions: Compared with PCI, revascularization with CABG was related to a lower incidence of HF hospitalization but a worse survival outcome in patients with severe CAD and reduced EF. CABG-associated reduction in HF hospitalization was more notable when SYNTAX score ≥33.
Classification of Ocular Diseases on Fundus Images Using Weighted MobileNetV2

The major cause of blindness in children and adolescents is the ocular disease. It is anticipated that there will be 1.76 billion people worldwide who will lose their eyesight by 2050. However, if the eye condition that caused it can be identified and treated quickly, blindness can be avoided. Therefore, in this research, we proposed a weighted MobileNetV2 to classify ocular disease on fundus images. MobileNetV2 network is chosen because it has a lightweight architecture that allows data to be processed faster. This research also proposed a weighted cost function to improve the performance of the network in handling imbalanced dataset problems. This is needed because usually, the medical dataset has a much lower number of data in the abnormal class than in the normal class, which may cause the deep learning algorithm to fail in detecting the abnormal class. Experimental results on a fundus image dataset that consists of 4 classes ("Normal", "Cataract", "Glaucoma", and "Retina Disease") shows that the proposed weighted cost function can improve the performance of the network on an imbalanced dataset with the accuracy of 66%, precision of 61%, recall of 58%, F1-score of 57%, and running time of 353.81 seconds. Moreover, the proposed weight calculation formula also gives the best performance among other weight calculation formulas.
Effect of Some Polysaccharide-Based Edible Coatings on Fresh White Button Mushroom (Agaricus bisporus) Quality during Cold Storage

This study investigated the effects of pectin, chitosan, sodium alginate, and carboxymethyl cellulose-based edible coatings, individually and/or in combination with N-acetyl cysteine as an antibrowning agent, on some physical, chemical, and antioxidant properties of white button mushrooms. The weight loss, color change, browning index, degree of cap opening, soluble solid content, total phenolic content, antioxidant activity and malondialdehyde content of control and coated mushrooms were evaluated during 14 days of storage at 4 ± 1°C. All coatings, both alone and with N-acetyl-cisteine, delayed weight loss and cap opening in mushrooms compared with the control. Sodium alginate was the most effective in controlling weight loss, followed by carboxymetyhyl cellulose, chitosan and pectin. The browning process and lipid peroxidation were best controlled by sodium alginate followed by pectin coatings, while chitosan coating determined a significant increase in the browning index. Coated samples showed significantly higher total phenolic content and antioxidant activity as compared with the control throughout storage. The treatment with N-acetyl cysteine was not effective for mushrooms as it resulted in a significant increase in the browning index in all coated samples. The results suggest that sodium alginate and pectin coatings could be recommended for extending the shelf life of white button mushrooms.
Non coherence de certains anneaux de fonctions holomorphes

le module des relations de u, u; on dit que le module R(u ,., u)est de type fini si il est engendr sur A par un nombre fini de ses lments; on dit que A est un anneau coherent si, pour tout k dans N et tout k-uple {u, u) d’lments de A, le module R(u,., u) est de type fini. W. McVoy et L. A. Rubel [1] ont montr que l’anneau/-/(D) des fonctions holomorphes et bornes dans le disque D de 12 est coherent; J. P. Rosay [2] a montr qu’il en tait de mme pour l’anneau des fonctions holomorphes et bornes dans un domaine born de 12 de connectivit finie; on se propose de montrer ici:
Optimum Rate and Deep Placement of Nitrogen Fertilizer Improves Nitrogen Use Efficiency and Tomato Yield in Nepal

In Nepal, blanket fertilizer recommendations without considering diverse soil types, nutrient status, climate and crop management practices along with imbalanced fertilization practices by farmers, mainly “urea fertilizer,” have resulted in reduced nitrogen use efficiency (NUE) and productivity in tomato production. Optimizing the rate of nitrogen (N) fertilizer, application time and improved application methods could increase crop yields and NUE and reduce environmental costs. This study was conducted to identify the optimum N rate and application method for increased tomato yield and NUE. Multilocation trials (n = 28) conducted in a randomized complete block design with nine treatments across five districts included the omission of N, P and K (N0, P0, K0), variable N rates of 100, 150, 200 and 250 kg ha−1 (N-100, N-150, N-200 and N-250), use of urea briquettes (UB) with deep placement (UBN-150) and a control (CK). N input in UB was reduced by 25% from the recommended N rate of 200 kg ha−1 considering its expected higher NUE. Yield responses from an NPK omission plot revealed N as the most limiting plant nutrient. Applications of fertilizer at N-100, N-150, N-200 and N-250 increased tomato yield by 27%, 35%, 43% and 27%, respectively, over N0. Tomato yields responded quadratically to the added N fertilizers with optimum rates ranging from 150 to 200 kg ha−1 across districts. UBN-150 significantly increased tomato yield by 12% over N-150 and produced a similar yield to N-200 (the recommended rate). The highest partial factor productivity of nitrogen (PFPN) was observed at N-100 and the highest agronomic efficiency of N (AEN) was at N-200. Deep placement of UB at-150 increased PFPN by 8% and 21% and AEN by 27% and 21% compared with N-150 and N-200, respectively. These results have positive implications for developing efficient N fertilization strategies to increase tomato yields and reduce environmental impacts in Nepal.
Risk Prediction of Earthquakes using Machine Learning

As the population of earthquake-prone areas continues to grow, the number of people killed and injured by earthquakes is also increasing. There are an increasing number of populated places that are at risk from earthquakes, but there is only a limited number of earthquake engineering professionals to deal with the problem. As a result of this, automatic intelligence-monitored warning and mitigation systems are required. According to the findings, in this paper, an artificial intelligence model based on machine learning is being built to enable an autonomous approach for analysing and identifying risk potential, then alerting stakeholders and initiating risk reduction steps. It is possible to monitor slope movement and deformations remotely and autonomously in a variety of ways, including through the use of automated seismograph connections and collaboration with local, state, and national disaster relief organisations. Damage models typical of India current urban infrastructure can be used in modelling and simulation scenarios, and nonlinear seismic analysis scenarios can be used for these models. People who work with machine learning in earth quake prediction applications can use data mining techniques like decision trees and geographic information systems to make their applications smarter by making them smarter.
ASSOCIATION BETWEEN METABOLIC SYNDROME AND CORONARY HEART DISEASE IN WOMEN PATIENTS AT DR. MOHAMMAD HOESIN HOSPITAL PALEMBANG

Metabolic syndrome is still a risk factor for coronary heart disease. This study aims to analyze the association between metabolic syndrome and coronary heart disease in women. This study is an observational analytic study using a cross-sectional design on 138 samples selected using consecutive sampling method and data were collected through observation of the medical records of patients at dr. Mohammad Hoesin Palembang. The results showed that the highest proportion of metabolic syndrome components in the sample of this study was hypertension (54.3%), while the lowest was hyperglycemia (26.8%). This study found a significant relationship between metabolic syndrome and coronary heart disease in female patients (p = 0.047). Female patients with metabolic syndrome had a 2.218 times greater risk of developing coronary heart disease (PR 2.218 95% CI = 1.072 - 4.587).
Audit of Operative Notes Against Royal College of Surgeons Guidelines in a Tertiary Health Care Surgical Unit in Lahore

Operative notes are important documentation made by the surgical team after a surgical procedure. They outline what happened during the surgery and several aspects of post-operative instructions. The aim of this audit was to compare current practices regarding documentation of these operative notes in a tertiary care hospital in Lahore. The standards used were the recommendations made in the good surgical practice guidelines by the Royal College of Surgeons (RCS) of England in 2014. A prospective closed-loop audit was conducted using a checklist constructed using the RCS guidelines. In the first audit, which was done to analyze current practices, 44 consecutive handwritten operative notes were evaluated. The findings of this initial audit were presented to the surgical team in a local meeting and recommendations were made. Forty-eight consecutive operative notes were then analyzed in the re-audit done after an interval of one month. The findings of the re-audit were presented to the surgical team. An overall 35.7% improvement was noted in the documentation of operative notes after the completion of the audit cycle. Certain parameters analyzed, such as thromboprophylaxis, antibiotic prophylaxis, and anticipated blood loss, were much more frequently documented in the re-audit. In our study, implementation of recommendations such as restructuring of the operative notes pro forma and improving awareness regarding the RCS guidelines significantly improved the quality of operative notes that were being documented. Such audits should be conducted regularly to maintain and improve the standards of documentation in all surgical units.
FACETS AND VERTICES OF TRANSPORTATION POLYTOPES

Abstract : Transportation polytopes are a special class of polytopes arising as sets of feasible solutions to transportation problems. The same polytopes are formed by all nonnegative matrices with specified row sums and column sums. Such matrices can be considered as generalized doubly stochastic matrices. The combinatorial structure--in particular, the number of vertices--of transportation polytopes is examined. (Author)
A COMPTON-THICK ACTIVE GALACTIC NUCLEUS AT z ∼ 5 IN THE 4 Ms CHANDRA DEEP FIELD SOUTH

We report the discovery of a Compton-thick active galactic nucleus (AGN) at z = 4.76 in the 4 Ms Chandra Deep Field South. This object was selected as a V-band dropout in HST/ACS images and previously recognized as an AGN from optical spectroscopy. The 4 Ms Chandra observations show a significant (∼4.2σ) X-ray detection at the V-band dropout position. The X-ray source displays a hardness ratio of HR = 0.23 ± 0.24, which, for a source at z ∼ 5, is highly suggestive of Compton-thick absorption. The source X-ray spectrum is seen above the background level in the energy range of ∼0.9–4 keV, i.e., in the rest-frame energy range of ∼5–23 keV. When fixing the photon index to Γ = 1.8, the measured column density is NH = 1.4+0.9−0.5 × 1024 cm−2, which is Compton thick. To our knowledge, this is the most distant heavily obscured AGN, confirmed by X-ray spectral analysis, discovered so far. The intrinsic (de-absorbed), rest-frame luminosity in the 2–10 keV band is ∼2.5 × 1044 erg s−1, which places this object among type-2 quasars. The spectral energy distribution shows that massive star formation is associated with obscured black hole (BH) accretion. This system may have then been caught during a major coeval episode of BH and stellar mass assembly at early times. The measure of the number density of heavily obscured AGN at high redshifts will be crucial to reconstructing the BH/galaxy evolution history from the beginning.
Disturbed Cardiac Metabolism Triggers Atrial Arrhythmogenesis in Diabetes Mellitus: Energy Substrate Alternate as a Potential Therapeutic Intervention

Atrial fibrillation (AF) is the most common type of sustained arrhythmia in diabetes mellitus (DM). Its morbidity and mortality rates are high, and its prevalence will increase as the population ages. Despite expanding knowledge on the pathophysiological mechanisms of AF, current pharmacological interventions remain unsatisfactory; therefore, novel findings on the underlying mechanism are required. A growing body of evidence suggests that an altered energy metabolism is closely related to atrial arrhythmogenesis, and this finding engenders novel insights into the pathogenesis of the pathophysiology of AF. In this review, we provide comprehensive information on the mechanistic insights into the cardiac energy metabolic changes, altered substrate oxidation rates, and mitochondrial dysfunctions involved in atrial arrhythmogenesis, and suggest a promising advanced new therapeutic approach to treat patients with AF.
Real World Management of Anaphylaxis Versus the National Institute for Health and Clinical Excellence (NICE) Guidelines

Objectives Anaphylaxis is an acute, life-threatening immediate allergic reaction caused by the sudden systemic release of mediators from mast cells. This study aims to assess the current practice of emergency management of children and adults diagnosed with anaphylaxis at the Royal Hospital, Muscat, Oman, in line with the National Institute for Health and Clinical Excellence (NICE) guidelines. Methods This is an observational retrospective study of all anaphylaxis cases seen at the emergency department (ED) from January 2013 to January 2018 and compared with the management of anaphylaxis in the ED as per the NICE guidelines. Inclusion criteria were all patients, children (age 16 and below), and adults diagnosed with anaphylaxis based on the World Allergy Organization (WAO) criteria. Exclusion criteria are all cases labeled as anaphylaxis that did not match the WAO criteria for anaphylaxis. Results Of 100 patients with a preliminary diagnosis of anaphylaxis, 49 patients (49%) were true-anaphylaxis cases based on the WAO definition 16 were children (age 16 years and below), and 33 were adults ( age 16 years and above). The other 51 patients (51%) with misdiagnosed anaphylaxis were later diagnosed with spontaneous urticaria, septic shock, vocal cord dysfunction, severe asthma, and anxiety attack. All 49 patients with true-anaphylaxis appropriately received adrenaline intramuscularly at the ED. All 16 children were admitted, seen by an allergist, and received an adrenaline auto-injector when indicated. Only 5 of the 33 adults were admitted and seen by an allergist, and 4 of those required an adrenaline auto-injector upon discharge. The remaining 28 adults were discharged from the ED, and only 3 of these were referred to the allergist. None received an adrenaline auto-injector upon discharge from the ED, and no mention in the ED notes on patient education regarding allergen avoidance. Conclusion Third of the patients who presented to ED were children (<16 years), and two third were adults. Insect venom was the main reason for anaphylaxis in both age groups. There was an underutilization of adrenaline auto-injector prescriptions for adult patients. This could be very well improved by disseminating policies and guidelines to adult physicians.
Mortality and Its Predictors among Adult Human Immune-Deficiency Virus-Infected Patients Attending Their Antiretroviral Treatment at Health Centers, Addis Ababa, Ethiopia: Multicenter Retrospective Cohort Study

Introduction In resource-limited settings such as Ethiopia, where the prevalence of HIV/AIDS is high, a number of factors, including economic, demographic, behavioral risk, and health factors, affect how long people with AIDS are treated with antiretroviral therapy. Since several aspects of the clinical setup may have an impact on ART patients' survival, this study was conducted in health centers. Determining the mortality rate and survival factors among adult HIV-infected patients receiving ART at health centers in Addis Abeba's Kirkos subcity is the primary goal of this study. Methods A retrospective cohort study was carried out at the health center in Addis Abeba's Kirkos subcity. The source population consisted of all adult HIV-positive patients who were being followed up between December 1, 2014, and October 30, 2019. A total of 665 samples were collected using a computer-generated simple random sampling method in each of the three health centers that were chosen by a lottery system depending on the number of patients in the follow-up. Trained data collectors took the information out of the patient card and the electronic database. Regressions using the Kaplan‐Meier and Cox proportional hazards were employed. Results The incidence of death rate in adult HIV-positive patients was 55 (8.5%) fatalities, translating to a death rate of 3.25 per 100 person-years. The majority of deaths occurred within 6 months of ART initiation. Predictors of mortality were: age above 50 years (AHR = 4.90, 95% CI: 2.00, 11.98), tuberculosis comorbidity (AHR = 3.46, 95% CI: 1.23, 3.33), lack of drug adherence (AHR = 1.76, 95% CI: 1.23, 3.33), co-trimoxazole therapy (AHR = 2.59, 95% CI: 1.37, 4.90), and CD4 cell count less than 200/dl (AHR = 2.77, 95% CI: 1.30, 5.92). Conclusion and Recommendation. Adult HIV-positive individuals had an incidence of the death rate of 55 (8.5%), which equates to 3.25 deaths per 100 person-years. Age category over 50, TB comorbidity, WHO stage IV, lack of medication adherence, co-trimoxazole therapy, body mass index under 18.5 kg/m2, and CD4 cell count under 200/dl were predictors of mortality. Therefore, it is important to focus on prevention, early identification, and treatment of HIV/AIDS for these predictors at all levels of the HIV/AIDS chronic care package in order to increase survival.
Women and videogames: What do they play?

The information on the use of Videogames (VG) in general samples fundamentally reflects the characteristics of men, because of their greater participation in VG, making it difficult to identify the characteristics of women and their gaming activity. Objective: To describe the gaming behaviour of adolescent and young women in Madrid, and its relation with the development of gaming problems. Method: A self-report questionnaire (Gamertest) was applied to a sample of 1,228 women (12 - 22 years old) (M = 14.84; SD = 2.469), selected by randomized sampling in schools in the Community of Madrid. Results: 51% of women admit gaming. The typical profile is a woman who plays VG sporadically and for short periods of time, preferably Action and Adventure games or Puzzles and Platforms, mainly on smartphones, at home and alone, with the purpose of having fun. The main predictive variables of gaming problems, identified with the Internet Gaming Disorder (IGD) in women are: a greater number of hours of use, playing Massively Multiplayer Online Role-Playing Game (MMORPG), and Strategy VG. The most protective factor is playing VG accompanied. The results are discussed. La información sobre el uso de Videojuegos (VJ) en muestras generales refleja fundamentalmente las características de los hombres, por su mayor participación en VJ, dificultando identificar las características de las mujeres y su actividad de juego. Objetivo: Describir el comportamiento lúdico de adolescentes y jóvenes madrileñas y su relación con el desarrollo de problemas de juego. Método: Se aplicó un cuestionario de autoinforme (Gamertest) a una muestra de 1.228 mujeres (12 - 22 años) (M = 14.84; DT = 2.469), seleccionadas mediante muestreo aleatorio en centros educativos de la Comunidad de Madrid. Resultados: el 51% de las mujeres admite jugar. El perfil típico es una mujer que juega a VJ de forma esporádica y por cortos periodos de tiempo, preferiblemente juegos de Acción y Aventura o Puzles y Plataformas; principalmente en smartphones, en casa y sola, con el propósito de divertirse. Las principales variables predictivas de problemas de juego, identificadas con el Trastorno del Juego de Internet (TJI) en mujeres son: mayor número de horas de uso, participación en juegos de rol multijugador masivo online (MMORPG) y VJ de estrategia. El factor protector más importante es jugar a VJ acompañado. Se discuten los resultados.