Miracle-dz/UniFAR-FTUs huggingface dataset:
FACTORS ASSOCIATED WITH MENTAL HEALTH LITERACY AMONG INTERNATIONAL POSTGRADUATE STUDENTS

Background: Drastic change in life demands would lead to mounting pressures on university students during their education years, which further leads to deteriorating in mental health, leading to suicide in some cases. International students face even additional pressers of living away from family and home. Since students displayed lacking in mental health literacy like the rest of the society in previous studies, empowering the students starts with improving their literacy on mental health. This study aims to measure the international students’ mental health literacy, to pave the way for future education programs on mental health specially designed for the international students’ community. Materials and Methods: A cross sectional study was carried out among the international postgraduate students in a public university in Malaysia, using the Mental Health Literacy Scale (MHLS). Variables were examined against the MHLS using mean-comparing formulas. Later, linear regression models used to predict the relationship between the MHLS score and the variables. Result: A total of 153 student participated in this study. The mean MHLS for the students is 111.42 point. Most of the students were males, between 25 to 34 years old. Females students, and the students who mentioned being to mental health professionals for personal reasons or with loved ones (BMHP) had higher MHLS (p<0.05). Conclusion: MHLS mean score came lower than two previous similar studies with comparable population. There is association between MHLS score and the variables Gender and BMHP.
Promoter Methylation-mediated Silencing of the MiR-192-5p Promotes Endometrial Cancer Progression by Targeting ALX1

Background: Epigenetic regulation by promoter methylation-mediated silencing of cancer-related microRNAs plays vital roles in tumorigenesis. MiR-192-5p promotes tumor progression in various human cancers with conflicting biological effects. However, its expression levels and biological functions in endometrial carcinoma (EC) have not been reported. Methods: The methylation status of miR-192-5p in tissue samples and cell lines, was examined using bisulfite sequencing PCR. miR-192-5p expression was also measured. EC cell lines transfected with specifically designed vectors overexpressing miR-192-5p, its target gene ALX1 or both, were constructed. Tumorigenicity of these cell lines were examined by in vitro and in vivo experiments. Dual-luciferase reporter assay were employed to verify the target of miR-192-5p. Results: The promoter region of miR-192-5p gene was highly methylated and its expression significantly repressed in EC samples. Moreover, a higher level of promoter methylation as well as a lower expression of miR-192-5p, was significantly associated with advanced Federation of Gynecology and Obstetrics stage and shorter disease-free survival in patients with curatively resected EC. Functional studies demonstrated that miR-192-5p overexpression inhibited in vitro tumor progression, in vivo tumorigenicity and the expression of several oncoproteins that was highly related to epithelial-to-mesenchymal transition. ALX1 was verified as a direct target of miR-192-5p and demonstrated to mediate the tumor-suppressive function of miR-192-5p. Conclusion: miR-192-5p is a tumor suppressor miRNA that is epigenetically silenced by promoter methylation and may serve as a potential prognostic biomarker in EC.
Juvenile Detention Alternatives Initiative, Zero-Tolerance Discipline, and the School-to-Prison Pipeline

Zero-tolerance discipline policies led to the introduction of police on school campuses and have resulted in a disproportionate number of in-school arrests and referrals of Black middle-school students, subjecting them to the school-to-prison pipeline. Data shows the negative effects of zero tolerance; however, less is known regarding alternative evidence-based strategies such as the Juvenile Detention Alternatives Initiative (JDAI). Grounded in the labeling theoretical framework, this study examined whether JDAI status (pre-JDAI and post-JDAI) could predict arrests and referrals while controlling for race, gender, and age. Secondary data were collected from a juvenile court in northwest Georgia on 1,303 middle-school students. The students who formed this purposive sample for the study were arrested or referred 2 years prior to the implementation of the JDAI School Referral Reduction Program and 2 recent years post-JDAI. Binary logistic regressions were conducted for each of the outcomes of arrests and referrals to ascertain the predictive relationships of JDAI, race, gender, and age. The results found only gender and age to be significant predictors of arrests and referrals. However, additional findings reported Black students were 89.4% of the students arrested or referred to the juvenile court, and 93.2% of those arrests and referrals occurred during the 2-year period preJDAI. This research is significant for stakeholders involved in education and juvenile justice reform who want to positively effect social change through the use of programs and policies that narrow the academic achievement gap and reduce the disproportionate number of Black students’ contact with the criminal justice system.
EFFECT OF SENSORIMOTOR TRAINING ON PAIN AND DISABILITY IN PHYSIOTHERAPY STUDENTS WITH NON SPECIFIC LOW BACK PAIN

Low back pain (LBP) is a common and costly problem, often associated with high recurrence rate and equivocal management efficacy. Low back pain remains the primary cause of absenteeism and disability in every industrialized society.1 About 80% of the popul more than once throughout their lives. Those experiencing acute low back pain, 90% recover within two months, but chronic low back pain triggers physical atrophy and psychological problems. Low back pain sustained for more t concluded that sensory motor training makes patients capable of learning how to adjust muscles, thereby alleviating pain and motor training in patients with LBP was less so the present study aims to analyses its impact and examine whether it should be considered as a treatment option for LBP. It was hypothesized that Sensory Motor Training will be equally or more effec exercises in patients with chronic non conducted natural sciences in dehradu by ethical committee of Dolphin (PG) Institute of Biomedical and Natural Sciences, Dehradun. Subjects were divided into 2 groups after informed consent was informed. Group A (Senso Training n=13), and Group B (Core Stability Exercises n=15). Numeric Rating Scale and disability each patient. intervention reading was calculated in the same manner as pre intervention after the end of 4 weeks. This study depicted that both Sensory motor training and Core Stability exercises are equally effective in reducing Pain and Disability in subject with Chronic Non Sensory motor training was found to be better impact when means were considered. So we could conclude that SMT is indeed a choice of treatment for patients with CNSLBP.
Effect Study A Nonsteroidal Antiinflammatory Drug (Indomethacin) on Fertility, Some Reproductive Norms and Histological Changes of Fetuses and Newborns of Administered Albino Rats Before Pregnancy

This study was executed in animal house of Education Faculty for girls –kufa university for 1-8-2020 to 1-11-2020 for detecting the effects of a nonsteroidal antiinflammatory drug (indomethacin) on fertility, some reproductive norms and histological changes of some organs of fetuses and newborns of administered albino rats before gestation, female and male albino white rats were used in this study with age rate (3months and 2.5 months) and weight rate(240 gm and 236 gm) respectively,the animal rats were divided into two groups:the first group was treated with normal saline and represented control group,the second group was treated with indomethacin drug before the pregnancy as following: The female and male rats were administered with indomethacin with concentration of 15 mg /kg of body weight for 30 days and 50 mg /kg of body weight for 60 days respectively, all experiment animals were administered orally one dose before mating by rat stomach tube before wiving,after that the animal rats were mated and left to the pregnancy,then some of the pregnant rats were dissected during 20 days period of the pregnancy,while the others renounced to the birth of study two groups. The results indicated that there was no influence on the fertility of male and female rats that were treated with indomethacin drug before pregnancy, pregnant female rats that were treated with indomethacin before pregnancy suffered from some cinical signs such as diarrhea, loss of appetite and lethargy during pregnancy,as the bleeding was observed during the birth in female rats compared with control group, the results recorded a significant reduce (P <0.05) in numbers of gross and living fetuses for (20)days of pregnancy and nweborns after birth , while numbers of absorbed fetuses for (20)days of pregnancy and newborns after birth significantly increased (P <0.05) in treated animals with indomethacin before pregnancy compared with control group, as wall as the result of current study showed that a significant reducing (P <0.05) in the weight of body and lengths of body,tail and limbs of fetuses for (20)days of pregnancy and newborns after birth in treated group with indomethacin before pregnancy when compared with control group,and also the treatment with indomethacin caused patho-histological changes in livers and kidneys of fetuses for (20)days of pregnancy and newborns after birth compared with control group. We conclude of this study that indomethacin which is one of the nonsteroidal antiinflammatory drugs that was administered to animal rats before pregnancy may have a cumulative effect inside the body making its harmful effects extend to the fetuses during pregnancy and newborns after birth.
NEW COVERS.cdr

A class of distribution-free tests for two-sample location problem is based on the signs of most extreme observations in the sub-samples of sizes c and d from X and Y samples respectively. The test statistics have been expressed in terms of linear rank statistics. The asymptotic normality of the test statistics is established. Asymptotic efficiencies indicate that members of our class do well in comparison with some already existing test statistics for light and medium tailed distributions.
Spatial-temporal Analysis of Soybean Productivity Using Geostatistical Methods

To have information about the soybean productivity over the crop years is essential to define strategies to increase profits and reduce costs and most important to reduce environmental impacts. One form of monitoring is the use of Geostatistical methods, which allow us to obtain maps with more accurate predictions. In this paper, an area of 127.16 ha was studied during six crop years between 2012/2013 and 2017/2018. We found that productivity values vary between crop years, mainly due to uncontrollable climatic factors. The removal of influential points caused changes in the predicted values showed in the maps, and the use of scaled semivariograms allowed us to obtain similar maps to those obtained considering the model without influential points, then there was no need to exclude observations. The use of a model with replicates helped to identify regions where productivity was lower. The use of explanatory variables allowed us to elaborate a more accurate thematic map in the 2017/2018 crop year, which was well evidenced by the prediction standard error map.
How Does the Modification of Maternity Leave Policies in Universities Impact the Birth Rate of the County?

A survey published by United Nations’ International Labor Organization in May 2014 showed that, among the 185 countries surveyed, America and Papua New Guinea were the only two countries that did not offer paid maternity leave. By July 2014, the states that offer paid maternity leave include California, Hawaii, New Jersey, New York, and Rhode Island. Whether paid or not, maternal leave policies are directly related to women’s decisions regarding when and how often to have children, as well as their employment choices. Given this importance, in 1993, the United States’s government passed the Family and Medical Leave Act to mandate maternity and parental leave. This study focuses on the correlation between maternity leave policies in universities and the birth rates of counties in which they are located. Data was collected from seventeen universities and counties before and after the maternity leave policy was implemented. Through running mathematical regression models, the results show that additional modification to maternity leave policies actually has a negative correlation with the birth rates. A more generous maternity leave policy does not necessarily change the birth rate’s status quo.With this result being discovered, the study can promote suggestions regarding the policies and further investigations based on the subject.
Multistimuli responsive polymeric nanosystems for theranostic applications

ABSTRACT This article describes the synthesis, and characterization of two novel multistimuli responsive polymeric nanosystems for theranostic applications. For this purpose, the poly(N-isopropylacrylamide-co-itaconic anhydride) [P(NIPAAm-co-IA)] copolymer was synthesized by a free radical initiated polymerization method, and subsequently a macrobranched terpolymer was synthesized by partial esterification of P(NIPAAm-co-IA) copolymer with monomethoxy poly(ethylene glycol) [PNIPAAm-co-(PIA-g-PEG)]. This terpolymer with carboxylic functional groups adsorbed onto the surface of Fe3O4 nanoparticles (MNHG (1)). In another experimental process the PEG end-capped itaconat macromonomer (PEGIAM) was adsorbed onto the surface of Fe3O4 nanoparticles, and then copolymerized with NIPAAm via a free radical initiated polymerization technique (MNHG (2)). The chemical structures of all samples as representatives were characterized by means of FTIR and 1H NMR spectroscopies. The LCST, morphologies, elemental compositions, and magnetic properties of the synthesized MNHGs were examined. The potential cytotoxic effects of the MNHGs were evaluated by MTT assay. According to the results, we envision that the synthesized MNHGs may be find theranostic applications, in part due to their smart physicochemical properties. GRAPHICAL ABSTRACT
Dark Triad Personality Traits and Selective Hedging

We study the relationship between risk managers’ dark triad personality traits (Machiavellianism, narcissism, and psychopathy) and their selective hedging activities. Using a primary survey of 412 professional risk managers, we find that managers with dark personality traits are more likely to engage in selective hedging than those without. This effect is particularly pronounced for older, male, and less experienced risk managers. The effect is also stronger in smaller firms, less centralized risk management departments, and family-owned firms.
Population dynamics and Efficacy of selected insecticides against chilli thrips, Scirtothrips dorsalis (Hood) in Kharif

This field trail was conducted at the central field, Department of entomology SHUATS, Prayagraj during Kharif August to November 2019 entitled Efficacy of selected insecticides against chilli thrips, Scirtothrips dorsalis (Hood) in Kharif. Seven treatments were taken against the chilli thrips, Scirtothrips dorsalis i.e., T1 Fipronil 5 SC, T2 Buprofenzin 25 SC, T3 Thiamethoxam 25 WG, T4 Imidacloprid 17.8 SL, T5 Flubendamide 24% SC, T6 Triazophos, T7 Indoxacarb 14.5 SC were evaluated against chilli thrips Scirtothrips dorsalis. Among the seven treatments T4 Imidacloprid (95.83%) has significantly superior treatment followed by Thiamethoxam (93.82%), Fipronil (92.86%), Buprofezin (91.74%), Indoxacarb (89.36%), Triazophos (88.10%), Flubendamide (86.39%) was found to be least effective against the chilli thrips. The plot which is treated with the Imidacloprid (175 q/ha) followed by Thiamethoxam (110 q/ha), (105 q/ha), Buprofezin (100 q/ha), Indoxacarb (95 q/ha), Triazophos (82.5 q/ha), Flubendamide (75 q/ha) as compared to control T0 (62.5 q /ha). The highest yield was noticed in Imidacloprid 17.8L (175 q/ha). followed by Thiamethoxam 25 WG (110 q/ha).
Taguchi Method and Taguchi-Pareto Scheme to Evaluate Diffusivity during the Development of Orange Peel Epoxy Composites

The evaluation of diffusion parameters of orange peel epoxy composites is currently crucial as they explain the movement and elimination of waste from the cells with important implications for the expected lifespan of the composite material. However, existing diffusion methods are unreliable as they yield sub-optimal designs, avoids the benefit of reduced cost of experimentation and extreme flexibility in composite designs, which can accommodate several design factors. Consequently, in this paper, the idea is to account for parametric optimization of composites in the classical Taguchi and prioritized parametric (Taguchi-Pareto) forms. An L16 orthogonal array was considered. Experiments were conducted in two sets with three and seven days intervals while the initial and final weights and the thickness of composites were measured. The optimal parametric setting for the three and seven days of diffusivity are both P4Q4R1 interpreted as 11.69g, 13.73g and 0.0224m (for three days) and 11.69g, 15.04g and 0.0221m (for seven days), respectively. These are for the initial weight, final weight and the thickness of the composites, respectively. By the Taguchi-Pareto method, the optimal setting leaves out the thickness parameters because it is not significant to optimality, confirmed by analysis of variance which showed that the thickness parameter is of less significance. The benefit of this attempt is to help composite manufacturers the commercial decision in design optimizations and produce low-cost composites.
DO ZAKAT AND TAX PAYMENT INCREASE ISLAMIC ORGANIZATION PERFORMANCE?

The purpose of this study is to investigate the impact of zakat and tax payment on the firm financial performance. The Motivation for this research is obligation for Islamic organization to obey the sharia law and rules of the country, by tax and zakat payment. Besides that, previous studies focuses on single country and conventional industries. Our sample comprises all islamic organization which discloses their zakat payment and tax payment for the period from 2007 to 2017. In contrast to previous study, this research using zakat payment as a islamic compliance indicator and tax payment as government compliance. Besides that, this study is cross country analysis. Our results indicate that highly zakat payment firms are more likely to increases their ROE and ROA. Also, highly tax payment firms are more likely to increases their ROE and ROA. Further, corporate charitable giving especially zakat and tax payment is important platform in increasing its corporate performance. Results of this study provide support to government especially tax department to considers about integration between zakat and tax in government law.
Aggregative Perivascular Tumor Cell Growth Pattern of Primary Central Nervous System Lymphomas Is Associated with Hypoxia-Related Endoplasmic Reticulum Stress

Primary central nervous system lymphomas (PCNSLs) often present a unique histopathological feature of aggregative perivascular tumor cells (APVT). Our previous studies showed that patients of PCNSL with APVTs exhibited poor long-term outcomes and increased expression of the endoplasmic reticulum stress (ERS) factor X-box-binding protein (XBP1). However, very little is known about molecular mechanism of the APVT formation in PCNSLs. The aim of this study is to determine if hypoxia-induced ERS is related to the APVT formation in PCNSLs. In this study, cell culture was used to observe the interplay between diffuse large B cell lymphoma (DLBCL) tumor cells and human brain microvascular endothelial cells (HBMECs) in different oxygen conditions. The expression of XBP1, CXCR and CD44 was manipulated by molecular cloning and siRNA technology. Mouse in vivo experiments and clinical studies were conducted to confirm our hypothesis. Our results showed that activated B-cell type-DLBCL cells easily migrated and invaded, and expressed high levels of XBP1 and stromal molecules CXCR4 and CD44 during hypoxia-induced ERS and dithiothreitol unfolded protein response (UPR). The gene upregulation (using overexpression vector) and downregulation (siRNA gene knock-out) in cultured cells and in mouse models further confirmed a close relation of the expression of XBP1, CXCR4, and CD44 with APVT formation, which is coincided with our clinical observation that increased expression of XBP1, CXCR4, and CD44 in the APVT cells in PCNSLs were associated with poor clinical outcomes. The results suggest that hypoxia-induced ERS and UPR might be associated with APVTs formation in PCNSL and its poor clinical outcomes. The results will help us better understand the progression of PCNSL with APVTs feature in daily pathological work and could be valuable for future target treatment of PCNSLs.
DMD064089 1218..1225

Diltiazem, a calcium channel blocker, is mainly metabolized via demethylation or deacetylation in humans. Diltiazem demethylation is catalyzed by cytochrome P450 2D6 and 3A4. Although it was previously reported that the area under the curve ratio of deacetyldiltiazem to diltiazem after oral dosing with diltiazem in rats was sevenfold higher than in humans, the molecular mechanisms underlying this species difference remain to be clarified. In the present study, we compared the diltiazem deacetylase activity in liver, intestinal, renal, and pulmonary microsome preparations of human and experimental animal tissues to identify the specific deacetylase enzyme(s) involved in deacetylation. Diltiazem deacetylase activity was detected in rat liver and small intestine microsome preparations, but not in those from human, monkey, dog, and mouse tissues. Further purification of rat liver microsome (RLM) proteins identified four carboxylesterase (Ces) enzymes (Ces1d, Ces1e, Ces1f, and Ces2a) as potential candidate deacetylases. On the basis of their tissue distribution, the Ces2a enzyme was considered to be the enzyme that was responsible for diltiazem deacetylation. Furthermore, recombinant rat Ces2a expressed in Sf21 cells displayed efficient diltiazem deacetylase activity with similar Km values as RLM. In addition, the inhibitory characteristics of various chemical inhibitors were similar between recombinant rat Ces2a and RLM. In conclusion, we determined that only rat tissues were able to catalyze diltiazem deacetylation. The characterization of Ces enzymes in animal species, as undertaken in this study, will prove useful to predict the species-specific pharmacokinetics differences between the in vivo models used for drug