Miracle-dz/UniFAR-FTUs huggingface dataset:
Pediatric Emergency Response in a Non-Epicenter Hospital during the 2023 Turkey-Syria Earthquake: A Retrospective Study of 125 Cases in the First 20 Days

Background The 2023 Turkey-Syria earthquakes affected a large population. Ankara Mamak State Hospital, a non-epicenter hospital, was also making efforts to treat earthquake patients. This retrospective study was conducted from this non-epicenter hospital during the 2023 Turkey-Syria earthquake and aimed to evaluate the emergency response to 125 pediatric patients identified in the first 20 days. Material/Methods The cases were scanned from the hospital’s electronic registry system by age and diagnosis code. We recorded the demographic data of patients under the age of 18 years, the day they arrived, the provinces they left, their diagnoses, treatments, consultations, characteristics of trauma in traumatic cases, and outcomes of all children in a non-epicenter hospital. We detected 125 pediatric cases in the first 20 days. Results There were 125 pediatric patients under the age of 18 who arrived to the Emergency Department (ED). On the 6th day, the number of cases peaked. Their mean age was 7.9±5.6 years (minimum: 0, maximum: 18) and 52.8% were males. Most cases had non-traumatic internal disease (81.6%) and were most (97.6%) were discharged from the ED. While soft-tissue injury was the most common diagnosis in traumatic cases (69.9%), there were more (56.5%) extremity injuries according to the affected body zone. Conclusions After major disasters, there may be an increased number of pediatric patients taken to hospitals far from the disaster area. For this reason, non-epicenter hospitals should be prepared to provide an adequate number of health care workers and sufficient supplies and equipment.
Reaction Rate Enhancement for Cu(In,Ga)Se2 Absorber Materials Using Ag-Alloying

The addition of Ag to Cu-Ga-In precursors for synthesizing (Ag,Cu)(In,Ga)Se2 (ACIGS) thin films has shown benefits including improved adhesion, greater process tolerance, and potential for improved device performance. In this study, reaction pathways to form Cu(In,Ga)Se2 (CIGS) and ACIGS were studied by time-progressive reactions at 450 °C in a 5% Ar/H2Se atmosphere followed by ex situ characterization. Results indicated that the addition of 25% Ag/(Ag+Cu) to the CIGS film reduces the reaction time by 50%. X-ray diffraction (XRD) analysis of CIGS films showed that the CuInSe2 phase initially formed after 3.5 min. The slow reaction of the stable γ-Cu9(In,Ga)4 phase, however, required more than 20 min to complete. Importantly, the addition of Ag to the CIGS film accelerated the reaction. Energy-dispersive X-ray spectroscopy shows that Ga/(Ga+In) grading occurs in the first 10 min of the reaction. XRD analysis showed that the chalcopyrite phase fully forms after 10 min and no significant changes were observed in samples selenized from 10–45 min. Reaction pathways of Ag-alloyed films were further characterized using in situ high temperature XRD analysis. The onset temperature of Se reaction was detected at 230 °C and a AgIn2 phase transformation to (Ag,Cu)In2 occurred during the early stage of the reaction.
Research on the use of space resources

The second year of a multiyear research program on the processing and use of extraterrestrial resources is covered. The research tasks included: (1) silicate processing, (2) magma electrolysis, (3) vapor phase reduction, and (4) metals separation. Concomitant studies included: (1) energy systems, (2) transportation systems, (3) utilization analysis, and (4) resource exploration missions. Emphasis in fiscal year 1982 was placed on the magma electrolysis and vapor phase reduction processes (both analytical and experimental) for separation of oxygen and metals from lunar regolith. The early experimental work on magma electrolysis resulted in gram quantities of iron (mixed metals) and the identification of significant anode, cathode, and container problems. In the vapor phase reduction tasks a detailed analysis of various process concepts led to the selection of two specific processes designated as ""Vapor Separation'' and ""Selective Ionization. '' Experimental work was deferred to fiscal year 1983. In the Silicate Processing task a thermophysical model of the casting process was developed and used to study the effect of variations in material properties on the cooling behavior of lunar basalt.
In vitro, in vivo and clinical studies comparing the efficacy of ceftazidime-avibactam monotherapy with ceftazidime-avibactam-containing combination regimens against carbapenem-resistant Enterobacterales and multidrug-resistant Pseudomonas aeruginosa isolates or infections: a scoping review

Introduction Carbapenem-resistant Enterobacterales (CRE) and multidrug-resistant Pseudomonas aeruginosa (MDR-PA) infections are associated with a high risk of morbidity, mortality, and treatment costs. We aimed to evaluate in vitro, in vivo and clinical studies comparing the efficacy of ceftazidime-avibactam (CZA) combination regimens with CZA alone against CRE and/or MDR-PA isolates or infections. Methods We systematically reviewed the relevant literature in CINAHL/MEDLINE, Pubmed, Cochrane, Web of Science, Embase, and Scopus until December 1, 2022. Review articles, grey literature, abstracts, comments, editorials, non-peer reviewed articles, non-English articles, and in vitro synergy studies conducted on single isolates were excluded. Results 22 in vitro, 7 in vivo and 20 clinical studies were evaluated. In vitro studies showed reliable synergy between CZA and aztreonam against metallo-β-lactamase (MBL)-producing isolates. Some studies indicated good in vitro synergy between CZA and amikacin, meropenem, fosfomycin and polymyxins against CRE isolates. For MDR-PA isolates, there are comparatively fewer in vitro or in vivo studies. In observational clinical studies, mortality, clinical cure, adverse events, and development of CZA resistance after exposure were generally similar in monotherapy and combination therapy groups. However, antibiotic-related nephrotoxicity and infection relapses were higher in patients receiving CZA combination therapies. Discussion The benefit, if any, of CZA combination regimens in MDR-PA infections is elusive, as very few clinical studies have included these infections. There is no currently documented clinical benefit for the use of CZA combination regimens rather than CZA monotherapy. CZA combined with aztreonam for serious infections due to MBL producers should be evaluated by randomized controlled trials. Systematic review registration https://www.crd. york.ac. uk/prospero/display_record. php? RecordID=278552, CRD42021278552.
A Web3 secure platform for assessments and educational resources based on blockchain

A rising number of educational solutions based on blockchain technology have been designed. Students and other authorities responsible for verifying certificates are very concerned about the authenticity of academic credentials, either because the institutions that issue them no longer exist or because they do not keep adequate records. Blockchain technology has much to offer in education, including its high level of security, improved data access control, low cost, improved accountability, identity authentication, transparency, increased trust, and improved efficiency in managing student records. We proposed a decentralized blockchain‐based secure platform for the storage of academic certificates and student assessments with double encryption. Apart from speeding up the verification process, it will increase the safety of personal education data and assessments of all kinds of misuse. The data would only be accessed using a stakeholder's private key, and storing documents on a blockchain would increase security. We proposed a framework to offer a secure channel for educational resources. We are storing documents over blockchain utilizing an IPFS distributed data server. We give a thorough explanation of the system development, design, and evaluation of the suggested solution in terms of security and cost. Finally, we put the proposed framework to the test by deploying a smart contract prototype on the Ethereum TESTNET network in a Windows environment. The study's findings revealed that the proposed method is effective and feasible.
Solidarity Through Difference? How Italian and Spanish LGBTQIA* Organizations Frame Solidarity Through an Intersectional Lens

ABSTRACT Although Western-based LGBTQIA* mobilizations have often been considered rather internally fragmented and isolated from other movements, recent investigations show that LGBTQIA* organizations have increasingly addressed multiple discriminations and built solidarity ties with communities coping with various inequality structures – such as race, class, and dis/abilities. This article addresses this puzzle by analyzing how political solidarity was framed by Spanish and Italian LGBTQIA* organizations during the 2011–2020 decade, paying particular attention to the nexus between diagnostic framing and solidarity discourses. To do so, this article examines the collective action events published on Facebook by LGBTQIA* organizations based in Milan and Madrid. Results show that, while LGBTQIA* actors dealt with cross-sectional issues in both cities, they differently framed problems and articulated diverse solidarity discourses.
Effect of calcitonin gene-related peptide on osteoblast differentiation in an osteoblast and endothelial cell co-culture system

We have investigated the in vitro effects and regulatory mechanism of CGRP (calcitonin gene‐related peptide) on the differentiation of OB (osteoblasts) in co‐culture with HUVEC (human umbilical vein endothelial cells). Primary human MOB (mandibular OB) and OB‐like cells (MG‐63) were either cultured directly or indirectly co‐cultured with HUVEC at a 1:1 ratio. Expression of OC (osteocalcin) was measured by ELISA, and expression of ALP (alkaline phosphatase) and collagen mRNA was measured by quantitative fluorescent PCR. For mineralization nodus, OB were stained with Alizarin Red‐S. When co‐cultured with HUVEC, expression of OC and ALP mRNA were increased in MG‐63 (P<0.01), and the expression of OC, ALP and collagen mRNA were increased in MOB (P<0.01 or 0.05). When treated with CGRP, OC and ALP mRNA and mineralization nodus numbers were increased in the MG‐63 co‐culture system (P<0.01 or 0.05); OC, ALP and collagen mRNA, and mineralization nodus numbers were increased in the MOB co‐culture system (P<0.01 or 0.05). The effect of CGRP regulation on the differentiation of OB is not only direct but also indirect, via its effect on HUVEC and stimulation of OB.
Unhealthy Dietary Patterns and Their Associations with Sociodemographic Factors as Predictors among Underweight and Overweight Adolescents in Southern Thailand

(1) Background: Adolescence is a critical developmental phase; dietary intake and nutritional status significantly impact health outcomes. (2) Objective: This cross-sectional study investigated dietary patterns (DPs) and the association between sociodemographic factors and unhealthy DPs among adolescents in Thailand. (3) Methods: A multi-stage sampling selected 1480 participants from three public high schools in Nakhon Si Thammarat province. A food frequency questionnaire assessed dietary habits, and principal component analysis was used to identify DPs. Multinomial logistic regression examined the association between sociodemographic factors and DPs. (4) Results: The findings show that 25.9% of adolescents were underweight, 14.7% were overweight, and 5.8% were obese. Three DPs were identified: a healthy ‘protein and vegetables’ pattern and two unhealthy patterns: ‘snacks’ and ‘processed foods’, which explained 12.49%, 10.37%, and 7.07% of the dietary variance, respectively. Among underweight adolescents, higher snack consumption was associated with being younger (odds ratio (OR) = 3.24) and receiving a higher daily allowance (OR = 3.43). Additionally, female adolescents who engaged in frequent exercise had a 2.15 times higher intake of processed foods. Among overweight adolescents, higher snack intake was linked to being younger (OR = 8.65) and having larger families (OR = 6.37). Moreover, an increased daily allowance was associated with higher consumption of processed foods (OR = 11.47). (5) Conclusion: This study underscores the socio-demographic influence on unhealthy DPs. Insights can guide targeted interventions to foster healthier dietary habits during adolescence.
Recent Topics of Laccase Focused on Chemical Reactions and Applications

Green chemistry elements should deal with enzymatic chemical reactions that are efficient or have a low environmental impact. Laccase is a readily available multicopper oxidase that has been extensively studied for a long time. In reviewing recent trends in laccase research, the authors selected themes that have not yet been evaluated, targeting open-access journals. From a chemical viewpoint, decomposition reactions (such as oxidation of substrates, toxic substances, pigments, and biomass materials), organic synthesis reactions, composite catalytic activities of oxygen reduction reactions, biosensors, batteries, biological fields, fermentation, culture, gene association, and antifungal activity.
Convergence of a variational iterative Algorithm for nonlocal vibrations Analysis of a nanotube Conveying fluid

The amplitudes of the forced oscillations of a nano-structure conveying fluid are the solutions of an inhomogeneous integral-differential system. This is solved by an easily accessible scheme based on the variational iteration method (VIM), Galerkin’s method and the Laplace transform techniques. The presented method is accompanied by the study of the convergence of the iterative process and of the errors. In the literature, the dynamic response of a viscoelastic nanotube conveying fluid is frequently obtained by an iterative method. This leads to the double convolution products, whose presence will be avoided in the new method proposed in this paper. Thus, the numerical results will be obtained much faster and more accurately.
Reactive Oxygen Species and H. pylori Infection: A Comprehensive Review of Their Roles in Gastric Cancer Development

Gastric cancer (GC) is the fifth most common cancer worldwide and makes up a significant component of the global cancer burden. Helicobacter pylori (H. pylori) is the most influential risk factor for GC, with the International Agency for Research on Cancer classifying it as a Class I carcinogen for GC. H. pylori has been shown to persist in stomach acid for decades, causing damage to the stomach’s mucosal lining, altering gastric hormone release patterns, and potentially altering gastric function. Epidemiological studies have shown that eliminating H. pylori reduces metachronous cancer. Evidence shows that various molecular alterations are present in gastric cancer and precancerous lesions associated with an H. pylori infection. However, although H. pylori can cause oxidative stress-induced gastric cancer, with antioxidants potentially being a treatment for GC, the exact mechanism underlying GC etiology is not fully understood. This review provides an overview of recent research exploring the pathophysiology of H. pylori-induced oxidative stress that can cause cancer and the antioxidant supplements that can reduce or even eliminate GC occurrence.
The effect of aerobic exercise training on asthma control in postmenopausal women (ATOM): a randomized controlled pilot study

ABSTRACT Objective To evaluate if high-intensity interval training three times weekly for 12 weeks improves asthma control in overweight, postmenopausal women with uncontrolled, late-onset asthma. Methods The reported study is a randomized clinical pilot study (www.clinicaltrials.gov; NCT03747211) that compared 12 weeks of high-intensity interval training (spinning) with usual care. The five-question Asthma Control Questionnaire (ACQ-5) was used as primary outcome. Secondary measures included systemic inflammation and inflammation of the airways, body composition, and cardiac function during exercise. Results We included 12 women with asthma (mean age 65 years (SD 6); mean body mass index 30 kg/m2 (SD 2)) from whom eight were randomized to exercise and four to control. Baseline ACQ-5 was 1.95 (SD 0.53) in the control group and 2.03 (0.54) in the exercise group. Patients had a mean blood eosinophil level of 0.16 × 109cells/L (SD 0.07) and a mean fraction of exhaled nitric oxide of 23 ppb (SD 25). Mixed models showed that participants in the exercise group reduced their ACQ-5 by 0.55 points (95%CI −1.10 to −0.00; P = 0.08) compared with the control group. The exercise group significantly reduced their mean body fat percentage (−2.7%; 95%CI −4.5 to −0.8; P = 0.02), fat mass (−2.8 kg; 95%CI −5.1 to −0.4; P = 0.044) and android fat mass (−0.33 kg; 95%CI −0.60- −0.06; P = 0.038). In analyses of cardiac measures, we saw no significant effects on right ventricular function (fractional area change), diastolic function or left ventricular function. Conclusions Although changes in ACQ-5 were slightly insignificant, these preliminary findings indicate that aerobic exercise training can be used as a means to improve asthma control in overweight, postmenopausal women with asthma.
Prognostic Role of Dynamic Changes in Serological Markers in Metastatic Hormone Naïve Prostate Cancer

Simple Summary In this exploratory analysis of a randomized controlled trial, we found that dynamic changes in simple laboratory-based markers such as prostate-specific antigen (PSA) could be used to predict survival in patients with metastatic prostate cancer that is sensitive to hormonal manipulation. We developed a model that captures information on dynamic changes in PSA along with hemoglobin (Hb), neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), and lymphocyte to monocyte ratio (LMR), and this model was found to be clinically more useful compared to the “treat all” strategy. This model could be used to design future adaptive trials that will investigate sequential treatment personalization in metastatic hormone sensitive prostate cancer patients. Abstract We investigated whether inter-patient variation in the dynamic trajectory of hemoglobin (Hb), neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), lymphocyte to monocyte ratio (LMR), and prostate-specific antigen (PSA) can prognosticate overall survival (OS) in de novo mHSPC. This is a secondary analysis of the LATITUDE trial in which high-risk de novo mHSPC patients were randomly assigned to receive either androgen deprivation therapy (ADT) plus abiraterone or ADT plus placebo. We used a five-fold cross-validated joint model approach to determine the association of temporal changes in the serological markers with OS. Decision curve analysis was applied to determine the net benefit. When dynamic changes in Hb, LMR, NLR, PLR, and PSA were included in a multivariate joint model, an increase in the log of the current value of PSA (HR: 1.24 [1.20–1.28]) was associated with inferior OS. A multivariate joint model that captured dynamic trajectory of Hb, NLR, PLR, LMR, and PSA up to 24 months, showed a net benefit over the “treat all” strategy at a threshold of probability of approximately ≥30% while no net benefit was seen when dynamic change in PSA was omitted. Our joint model could be used for designing future adaptive trials investigating sequential treatment personalization.
The multiple functions of miR-574-5p in the neuroblastoma tumor microenvironment

Neuroblastoma is the most common extracranial solid tumor in childhood and arises from neural crest cells of the developing sympathetic nervous system. Prostaglandin E2 (PGE2) has been identified as a key pro-inflammatory mediator of the tumor microenvironment (TME) that promotes neuroblastoma progression. We report that the interaction between the microRNA miR-574-5p and CUG-binding protein 1 (CUGBP1) induces the expression of microsomal prostaglandin E2 synthase 1 (mPGES-1) in neuroblastoma cells, which contributes to PGE2 biosynthesis. PGE2 in turn specifically induces the sorting of miR-574-5p into small extracellular vesicles (sEV) in neuroblastoma cell lines. sEV are one of the major players in intercellular communication in the TME. We found that sEV-derived miR-574-5p has a paracrine function in neuroblastoma. It acts as a direct Toll-like receptor 7/8 (TLR7/8) ligand and induces α-smooth muscle actin (α-SMA) expression in fibroblasts, contributing to fibroblast differentiation. This is particularly noteworthy as it has an opposite function to that in the TME of lung carcinoma, another PGE2 dependent tumor type. Here, sEV-derived miR-574-5p has an autokrine function that inhibits PGE2 biosynthesis in lung cancer cells. We report that the tetraspanin composition on the surface of sEV is associated with the function of sEV-derived miR-574-5p. This suggests that the vesicles do not only transport miRs, but also appear to influence their mode of action.
Evaluation of a Granular Bone Substitute for Bone Regeneration Using an Optimized In Vivo Alveolar Cleft Model

Alveolar cleft is a common congenital deformity that requires surgical intervention, notably using autologous bone grafts in young children. Bone substitutes, in combination with mesenchymal stem cells (MSCs), have shown promise in the repair of these defects. This study aimed to evaluate the regenerative capabilities of a granular bone substitute using an optimized alveolar cleft model. Thirty-six rats underwent a surgical procedure for the creation of a defect filled with a fragment of silicone. After 5 weeks, the silicone was removed and the biomaterial, with or without Wharton’s jelly MSCs, was put into the defect, except for the control group. The rats underwent μCT scans immediately and after 4 and 8 weeks. Analyses showed a statistically significant improvement in bone regeneration in the two treatment groups compared with control at weeks 4 and 8, both for bone volume (94.64% ± 10.71% and 91.33% ± 13.30%, vs. 76.09% ± 7.99%) and mineral density (96.13% ± 24.19% and 93.01% ± 27.04%, vs. 51.64% ± 16.51%), but without having fully healed. This study validates our optimized alveolar cleft model in rats, but further work is needed to allow for the use of this granular bone substitute in the treatment of bone defects.
Adverse Effect of Metallic Gold and Silver Nanoparticles on Xenopus laevis Embryogenesis

Exposure to metal nanoparticles is potentially harmful, particularly when occurring during embryogenesis. In this study, we tested the effects of commercial AuNPs and AgNPs, widely used in many fields for their features, on the early development of Xenopus laevis, an anuran amphibian key model species in toxicity testing. Through the Frog Embryo Teratogenesis Assay—Xenopus test (FETAX), we ascertained that both nanoparticles did not influence the survival rate but induced morphological anomalies like modifications of head and branchial arch cartilages, depigmentation of the dorsal area, damage to the intestinal brush border, and heart rate alteration. The expression of genes involved in the early pathways of embryo development was also modified. This study suggests that both types of nanoparticles are toxic though nonlethal, thus indicating that their use requires attention and further study to better clarify their activity in animals and, more importantly, in humans.