Miracle-dz/UniFAR-FTUs huggingface dataset:
colon-specific cancer mouse model

Although synbiotics may be effective in maintaining remission of inflammatory bowel disease, their anticarcinogenic effects are still debated. To address this issue, we evaluated the effects of synbiotics, probiotics, and prebiotics on tumorigenesis using a CDX2P-Cre; Apc+/flox mouse model harboring a colon-specific Apc knock out, which develops adenoma and adenocarcinoma of the colon. Dextran sodium sulfate (DSS)administration promoted colonic tumor development in CDX2P-Cre; Apc+/flox mice, and these tumors were associated with loss of Apc heterozygosity, as confirmed by observation of well-differentiated adenocarcinomas with β-catenin accumulation in tumor cell cytoplasm. Synbiotics-treatment suppressed dextran sodium sulfate-induced colitis in CDX2P-Cre; Apc+/flox mice, thereby reducing mortality, and inhibited tumorigenesis accelerated by DSS-administration. Conversely, neither probiotics nor prebiotics had any effect on inflammation and tumorigenesis. Lactobacillus casei and Bifidobacterium breve were detected in the fecal microbiota of probiotics-treated mice. Synbiotics-treatment suppressed DSS-induced expression of IL-6, STAT-3, COX-2, and TNFgene transcripts in normal colonic epithelium, indicating the possibility of suppressing tumor development. Importantly, these genes may be potential therapeutic targets in inflammation-associated colon cancer.
MRI predictors of deep grey matter atrophy in relapsing remitting and progressive multiple sclerosis patients

Poster: "ECR 2019 / C-3119 / MRI predictors of deep grey matter atrophy in relapsing remitting and progressive multiple sclerosis patients" by: "G. Pontillo, S. Cocozza, M. Di Stasi, C. Paolella, E. A. Vola, G. Palma, R. Lanzillo, A. Elefante, A. Brunetti; Naples/IT"
Study on the epidemiologic characteristics and medical burden of falls among older adults in community

Objective To study the epidemic characteristics and medical burden of falls among older adults in community.Methods Fall surveillance was carried out among 1 690 older adults from 2 communities of Changning district,Shanghai,those who fell with an injury were followed afterwards.Results There were 304 faller cases with mean age 75.14,including 86 males and 218 females.As for the fallers' intrinsic reasons, there was a significant difference between different places.As for environmental reasons,similar outcome was found.57. 9% of the 304 fallers needed medical care and 14.1% of them were hospitalized.Fall in older adults mostly lead to fracture and surface injury.The median medical cost of falls was 700 RMB.49. 3% of the 304 fallers had a more or less impact on their mobility.There were about 23.4% of the 304 fallers who did not take correct fall prevention measures.Conclusions Fall among older adults in community has a relatively severe impact on their health and lead to more or less medical burden.Fall prevention measures should be taken in community.
Why Are Subject Wh-Questions More Difficult than Object Wh-Questions? A Study of Japanese Young Learners of English

Minimalism (Chomsky, 2000, 2001, 2004) has shifted the focus from the setting of individual formal features to the composition of features onto particular lexical items in functional categories. Features are selected from a universal inventory made available by Universal Grammar (UG, the tacit knowledge of the grammar with which a human is born) and bundled up with other relevant features on a morphological item in a language-specific way. This is based on the two continuous processes that Chomsky characterises as language acquisition: (1) a one-time selection of a particular [F] (a subset of linguistic features) from F (a universal set of linguistic features); (2) a one-time assembly of a particular Lex (the lexicon of a language L) from F. Generative second language acquisition (SLA) research has provided a number of hypotheses to account for persistent difficulty in L2 acquisition, by focusing on feature-related properties. For example, the Interpretability Hypothesis (Hawkins & Hattori, 2006; Tsimpli & Dimitrakopoulou, 2007) associate the locus of acquisition problems with the unavailability of the uninterpretable features which were not selected or activated in the L1. This hypothesis suggests the permanent deficit of L2 grammar. The Feature Reassembly Hypothesis (Lardiere, 2008, 2009), on the other hand, attributes L2 learners’ variability to L1-L2 differences in featural assembly which are “acquirable” (Lardiere, 2013:10). This view reflects unimpaired L2 grammar, although the ease or difficulty of the acquisition is assumed to depend on L1-L2 pairings. The current study contributes to the discussion by focusing on how the features are involved in the particular difficulty experienced by Japanese learners with English subject wh-questions. This paper reports on an empirical study that investigates how Japanese young L2 learners acquire English single wh-questions. English and Japanese have the same features (wh/Q/case) but with their respective different compositions. Furthermore, English wh-questions have another [+tense] feature and there are also differences between subject and object wh-questions, while Japanese wh-questions have neither tense feature nor distinctions between the two types of wh-questions. This study will show a sharp contrast in accuracy between subject wh-questions (7.3%) and object wh-questions (74.5%). The lower accuracy rate of subject wh-questions is attributable to two kinds of unnecessary lexical items:
Mapping of Subsurface Geological Structure and Land Cover Using Microgravity Techniques for Geography and Geophysic Surveys: A Case Study of Maluri Park, Malaysia

A microgravity investigation on bedrock topography was conducted at Maluri park reference level in Kuala Lumpur, Malaysia. The study aim to mapping the near-surface structure and soil and land cover distribution for geography and geophysics surveys. Two types of crosssection modeling of the residual anomaly generated the MaluriBouguer Anomaly model for site-1 and site-2 at Maluri Park. The 2D microgravity models produced the contour map, displaying the characterization due to density contrast in rock types while mapping the subsurface geological structure at different depths. Moreover, a synthetic model was initiated with the assumption of lateral distance on the left and right sides taken at 50 m and a depth of 60 m. The results of modeling confirmed that the soil and rock type composition on both models site tests are topsoil (1.1 to 1.92 g/cm), soil (1.8 g/cm), clay (1.63 g/cm), gravel (1.7 g/cm), sand (2.0 g/cm), shale (2.4 g/cm), sandstone (2.76 g/cm), and limestone (2.9 g/cm). The 2D gravity modeling using two model site tests obtained a correspondence with the observed microgravity data.
About the National Center for Sustainable Transportation

16. ABSTRACT We studied coyotes separated by Interstates 680 and 580 in the inland valleys of the East Bay and coyotes separated by Interstate 80 and U.S. 50 in the lower Sierra Nevada Foothills. Fecal sampling was conducted in open space and parklands in regions adjacent to these highways. All samples were collected ≤ 10 km from the highways. After sample collection DNA extraction and genetic analysis, the results were analyzed for genetic diversity and genetic connectivity.High quality genetic information was obtained for fifty-nine individual coyotes from 128 coyote samples. Despite the small sample size we still discovered some evidence of genetic divergence among sampling locations related to highway presence. However it is unclear from our current dataset whether highways form significant barriers to coyote movements in the Bay Area and Sierra Nevada foothills. Our results contrast with the findings of Riley, who studied coyote movements and gene flow across Highway 101 in Southern California. In that study Riley detected two populations, corresponding to the north and south sides of Highway 101. In our study areas, there is no distinct break between populations that can be attributed to highways alone. Both Riley and this study identified migrants across highways although the levels of population structure in Riley suggested that little gene flow occurred. The lack of population structure in our study areas suggests there is gene flow across highways, which may be facilitated by crossing points such as culverts and underpasses. The research team will continue to analyze coyote DNA from the study area and update the results at no cost to Caltrans.
Psychological Climate, Employee Engagement and Affective Organisational Commitment: The Oil and Gas Employees’ Perspective

Recent years may have seen a growing number of empirical research on the antecedents and outcomes of employee engagement. However, previous studies have tended to examine the topic in industries other than the oil and gas industry. From the social exchange theory perspective, this study investigated the process by which oil and gas employees’ perceptions of psychological climate are related to their engagement and affective organisational commitment. Data were obtained from a total of 242 oil and gas employees in East Malaysia via a self-administered questionnaire. The partial least squares method was employed to test the proposed model. The data provided empirical support for all the hypothesised relationships. Implications of the findings and suggestions for future research are discussed. JEL Classification: J30, M540
Influence of weight loss on heart rate variability in dogs

Mário dos Santos Filho1*, Daniel Carvalho Hainfellner2, Nathália Marques de Oliveira Lemos3, Camila de Oliveira Ferreira Mendes4,5, Patrícia Malandrim6, Jenifer Marques Campos7, Sophie Ballot8, Priscila Cardim de Oliveira9 & Jonimar Pereira Paiva10† 1Veterinary, MSc, Doctoral Student. Programa de Pós-graduação em Medicina Veterinária Ciências Clínicas, Universidade Federal Rural do Rio de Janeiro – UFRRJ, Seropédica, RJ, Brasil 2Veterinary, MSc, Autonomous. Rio de Janeiro, RJ, Brasil 3Veterinary, Master’s Degree Student. Programa de Pós-graduação em Medicina Veterinária, Universidade Federal Rural do Rio de Janeiro – UFRRJ, Seropédica, RJ, Brasil 4Young Veterinary Scholar. Programa Jovem Veterinário Nestlé Purina, Seropédica, RJ, Brasil 5Veterinary Student. Instituto de Veterinária, Universidade Federal Rural do Rio de Janeiro – UFRRJ, Seropédica, RJ, Brasil 6Veterinary, Autonomous. São João da Boa Vista, SP, Brasil 7Veterinary, Autonomous. Barbacena, MG, Brasil 8Veterinary Student, PIBIC-CNPq Scholarship Holder. Universidade Federal Rural do Rio de Janeiro – UFRRJ, Seropédica, RJ, Brasil 9Veterinary, MSc, Doctoral Student. Programa de Pós-graduação em Ciência Veterinária, Universidade Federal Rural do Rio de Janeiro – UFRRJ, Seropédica, RJ, Brasil 10Veterinary, Dsc. Departamento de Medicina Veterinária e Cirurgia, Instituto de Veterinária, Universidade Federal Rural do Rio de Janeiro – UFRRJ, Seropédica, RJ, Brasil †Deceased How to cite: Santos Filho, M. , Hainfellner, D. C. , Lemos, N. M. O. , Mendes, C. O. F. , Malandrim, P., Campos, J. M. , Ballot, S. , Oliveira, P. C. , & Paiva, J. P. (2019). Influence of weight loss on heart rate variability in dogs. Brazilian Journal of Veterinary Medicine, 40, e98119. doi: 10.29374/2527-2179. bjvm98119
Evaluating the antimicrobial potency of crude extracts of Psidium guajava bark, leaves of Vernonia amygdalina, Carica papaya and whole plant of Phyllanthus niruri against specific pathogenic bacteria

The potency of hot water, cool water and ethanoilc extracts of bark and leaves of Psidium guajava, leaves of Vernonia amydalina, Carica papaya and whole plant of Phyllanthus niruri were assessed against isolates of Escherichia coli, Salmonella typhi, Pseudomonas aeruginosa, Staphylococcus aureus, and Candida albicans obtained from the Mampong Research Institute of Herbal medicine in the Eastern region of Ghana. Antibacterial tests were carried out using the agar wells diffusion method. The susceptibility test results showed that extracts of P. niruri are very effective on all gram negative bacteria and extracts of Psidium guajava were effective on both gram negative and positive bacteria. Although V. amygdalina extracts showed inhibition to some bacteria in both hot water and ethanolic extract, hot water extract of C. papaya showed inhibition to S. aureus and S. typhi but room water extracts of both V. amygdalina and C. papaya showed quite a good results. Hence the potency of these plants base on their inhibition zones can be effectively used on some infectious disease caused by the test bacteria. Key words: Antimicrobial, Crude extracts, Psidium guajava, Phyllanthus niruri, Vernonia amydalina, Carica papaya, bacteria.
Hypertension and associated factors in Atlantic region of Benin in 2015: A community-based study

Hypertension is a major public health problem that does not spare Sub-Saharan Africa and especially Benin. There is scarce data on the factors associated with this condition in areas of high population pressure in Benin. We investigated factors associated with hypertension in Atlantic region. We conducted a cross-sectional survey in Benin in the Atlantic region for people aged 18 and over. This was an analysis of data collected during the STEPS Chronic Disease Risk Factor Surveillance Survey during the last quarter of 2015. We estimated the overall prevalence of hypertension and determined associated factors using a logistic regression model including factors with a p-value less than 0.20 in the univariate analysis. The overall prevalence of hypertension was 33.2% [95% CI (29.8-36.7)]. Age was associated with hypertension (global p-value ≤ 0.001). In addition, obesity and high salt intake were independently associated with hypertension AOR; 95%CI were 4.89 (2.74 - 8.73) and 1.54 (1.07 - 2.21), respectively. In the Atlantic region of Benin, factors associated with hypertension were age of at least 35 years, obesity and high salt consumption. Strategies that promote physical activity, reducing salt intake and fat could decrease the burden of the disease. Key words: Hypertension, associated factors, age, obesity, salt, Benin.
A Pulse Signal Preprocessing Method Based on the Chauvenet Criterion

Pulse signals are widely used to evaluate the status of the human cardiovascular, respiratory, and circulatory systems. In the process of being collected, the signals are usually interfered by some factors, such as the spike noise and the poor-sensor-contact noise, which have severely affected the accuracy of the subsequent detection models. In recent years, some methods have been applied to processing the above noisy signals, such as dynamic time warping, empirical mode decomposition, autocorrelation, and cross-correlation. Effective as they are, those methods are complex and difficult to implement. It is also found that the noisy signals are tightly related to gross errors. The Chauvenet criterion, one of the gross error discrimination criterions, is highly efficient and widely applicable for being without the complex calculations like decomposition and reconstruction. Therefore, in this study, based on the Chauvenet criterion, a new pulse signal preprocessing method is proposed, in which adaptive thresholds are designed, respectively, to discriminate the abnormal signals caused by spike noise and poor-sensor-contact noise. 81 hours of pulse signals (with a sleep apnea annotated every 30 seconds and 9,720 segments in total) from the MIT-BIH Polysomnographic Database are used in the study, including 35 minutes of poor-sensor-contact noises and 25 minutes of spike noises. The proposed method was used to preprocess the pulse signals, in which 9,684 segments out of a total of 9,720 were correctly discriminated, and the accuracy of the method reached 99.63%. To quantitatively evaluate the noise removal effect, a simulation experiment is conducted to compare the Jaccard Similarity Coefficient (JSC) calculated before and after the noise removal, respectively, and the results show that the preprocessed signal obtains higher JSC, closer to the reference signal, which indicates that the proposed method can effectively improve the signal quality. In order to evaluate the method, three back-propagation (BP) sleep apnea detection models with the same network structure and parameters were established, respectively. Through comparing the recognition rate and the prediction rate of the models, higher rates were obtained by using the proposed method. To prove the efficiency, the comparison experiment between the proposed Chauvenet-based method and a Romanovsky-based method was conducted, and the execution time of the proposed method is much shorter than that of the Romanovsky method. The results suggest that the superiority in execution time of the Chauvenet-based method becomes more significant as the date size increases.
Issn: 1307-9581 RELATIONSHIP BETWEEN INTERNET ADDICTION IN ADOLESCENTS AND FAMILY RELATIONSHIPS: A SYSTEMATIC REVIEW

Internet usage increases and becomes problematic gradually in adolescents. The aim of this systematic review is to investigate the relationship between internet addiction in adolescents and family relationships. This systematic review was conducted according to the guide “Centre for Reviews and Dissemination” with scanning databases Pubmed, Cochrane, Medline, EBSCO, Science Direct, Google Akademik and Ulakbim (Turkish National Databases). In the research, “problematic,” “internet usage,” “internet addiction,” “adolescence,” “family relationship,” “family functioning,” “adolescent,” and “parents” were used as key words. Scannings were completed between the dates November 2017-January 2018 with various combinations of the key words. With scanning the key words, 1017 studies were analyzed based on titles. Summaries of 309 studies saved as a title were investigated. As a result of investigations made according to titles and summaries, 7 studies got involved in the research. Studies involved in the research show that internet addiction problem exists almost in every continent of the world. Adolescents having not a healthy family relationship with their parents has an important role in developing internet addiction. Results of the research being a guide for psychiatric nursing practices and making a contribution on the literature are aimed.
ISAR-REACT 5 : should this trial change clinical practice ?

Prasugrel and ticagrelor are oral P2Y12 receptor inhibitors indicated by the European Society of Cardiology as the preferred antiplatelet therapy in patients with acute coronary syndrome (ACS). Despite the long-term and widespread presence of these agents in clinical practice, to date they have never been directly compared in a large, randomised clinical trial. ISAR-REACT 5 was the first such study, and it reported the superiority of prasugrel over ticagrelor. However, due to the arguable methodology of both the planning and the execution of this study, its results should be interpreted with caution, and they should not be considered sufficient to justify any changes to the current treatment strategies for patients with ACS.
An Introduction to Information Theoretic Learning, Part II: Applications

With the increasing number of machine learning problems that are out of the linear and Gaussian paradigm, information theoretic learning (ITL) rises as a research field that proposes a modeling method with a wealthier statistical treatment of the adaptation criterion. In the first part of this tutorial, we introduce the main concepts of ITL and a key set of estimators that enable the implementation of algorithms, in the context of a wider view independent of the differentiability property.
A sustainable bioelectricity production from wastewater

Rapid industrialization contributes to large quantities of wastewater generation, and its treatment is highly imperative. Various technologies for reducing the wastewater treatment cost and finding ways to produce useful products from wastewater is gaining importance in view of environmental sustainability. During the anaerobic wastewater treatment process, chemical energy is used for converting waste to H2, CO2 and methane. Among them, hydrogen and methane can be used as fuel, but in microbial fuel cells (MFCs) chemical energy available in wastes are directly converted to electricity (Walter et al., 2019). Exploiting wastewater as a substrate to generate electricity is considered to be a sustainable and a promising approach to meet the increasing energy needs, and also as a substitute for fossil fuels (Pant et al., 2012; Logan, 2015; Cao et al., 2019). Therefore, the aim of this work is studying the effect of different anode material, different concentrations of salt in the salt bridge, different carbon sources, and different mediators on power generation.
Perfectionist Types in the English as a Foreign Language Teaching Profession in Russia

This study examines perfectionism in the English language teaching profession in Russia. The aims are threefold: 1) to use latent profile analysis (LPA) to classify English as a foreign language (EFL) teachers into different types of perfectionists; 2) to compare different types of perfectionists using depression-anxiety-stress indicators (DASS); 3) to study the link between perfectionism and the perception of one’s professional teaching activity. We used convenience sampling by collecting data from 117 English teachers (5% males, 95% females; age range 20-64; M= 39; SD=12) with the Short Almost Perfect Scale (SAPS) and the Depression Anxiety Stress Scale-21 (DASS-21). LPA was conducted to determine the optimal number of types of individuals based on their SAPS profile. Three distinct classes of perfectionists were found (adaptive, maladaptive, non-perfectionists). 27% of the respondents fell into the category of maladaptive perfectionists with high scores on both the Standards and Discrepancy subscales. Teachers with higher Standards tend to be more aware of their perfectionism. Teachers who are less satisfied with their English proficiency tend to be more stressed at work. However, the results of the study did not indicate significant differences between the perfectionist types on anxiety, depression, and stress. The findings suggest the need to develop these scales further for measuring perfectionism in the teaching profession and in EFL teaching particularly.
Treatment of relapsing multiple sclerosis with Erhuang Formula

Objective To observe the clinical effect of Erhuang Formula on relapsing multiple sclerosis.Method To divide randomly 65 cases of multiple sclerosis into the control group(n=35) and the(treatment) group(n=30). The control group was treated with routine western medicine mainly with(methylprednisolone) and prednisone,and the treatment group was treated with Erhuang(Formula) besides of routine western medicine once a day for 3 or 4 weeks.Result Erhuang Formula(relieved) obviously(acroagnosis) and melagra(P0.001) and acroparalysis and dysopia too.Erhuang(Formula) had a(potential) effect on aconuresis and encopresis.It also decreased the ratio of leukocylosis(induced) by(hormones.) Conclusion The treatment of relapsing multiple sclerosis with(routine) western medicine (combined) Erhuang Formula can relieve neurological symptoms,reduce side effects of hormones and(improve) the rehabilitation.