Miracle-dz/UniFAR-FTUs huggingface dataset:
Melt migration through high-level gabbroic cumulates of the East Pacific Rise at Hess Deep : The origin of magma lenses and the deep crustal structure of fast-spreading ridges

the growth of ocean crust. Gabbroic rocks from Hess Deep, drilled during ODP Leg 147, record processes of melt migration and channelized magma flow and provide direct evidence that the entire thickness of the gabbroic layer forms simultaneously, not from the top down as previously believed. In the “top down” model, the gabbroic layer is formed by the downward accumulations of crystals settling out of the magma lens. In this model, the cumulate crystals build downward with high melt porosity and compact slowly to produce the gabbro layer. However, the mineral chemistry of the gabbros shows that they were crystallized from very hot melts, chemically unlike those found at site 894 (oxide-rich ferrogabbros and tonalite dikelets) interpreted to be the frozen residues of a magma lens.
The Impact of Myofascial Release Therapy and Deep Oscillation Therapy on Hamstring Muscle Length and tone in Children with Spastic Cerebral Palsy: A Comparative Study

BACKGROUND: As a result of restricted joint range of motion due to spasticity in patients with spastic cerebralpalsy, the patient’s ability to regain normal functioning may be hindered.PURPOSE: To evaluate the effectiveness of Myofascial Release Therapy (MFR) versus Deep Oscillation Therapy(DOT) in helping children with spastic cerebral palsy to relax and extend their hamstring range of motion.METHODOLOGY: A total of 32 individuals with spastic cerebral palsy, aged 2 to 10, were recruited for thiscomparative experimental study through a method of random sampling. Sixteen subjects were assigned to eachgroup. Group 1(N=16) received two sessions of MFR with conventional exercise per day, whereas Group 2(N=16)received a single session of DOT with conventional exercise per day. Throughout the course of four weeks, bothgroups got therapy five days per week. A universal goniometer was used to compare the knee extension passiverange of motion (PROM), active range of motion (AROM), and Popliteal angle (POP angle) measurements betweenthe pre- and post-treatment periods. Statistical analyses were conducted using ANOVA 2×2 and Post hoctables.RESULT: Both groups’ post-mean values for each of the dependent variables (AROM, PROM, and POP angle)statistically improved (p< 0.05). Both groups’ mean differences in the PROM and POP angles were statisticallysignificant, and Group 1’s spastic hamstring muscle was more improved than Group 2’s, but both groups’ AROMshowed almost equal improvement.CONCLUSION: In children with spastic cerebral palsy, both MFR and DOT, when combined with conventionaltherapy, reduce spasticity and increase length (AROM & PROM) in the hamstring muscle. However, our studyclearly shows that MFR is more successful than DOT.
Evaluation Agro-morphologique de Quelques Génotypes Locaux de Pois Chiche d’Hiver (Cicer arietinum L.) en Tunisie

Correspending author : khkobe@hotmail.com Abstract Thirteen kabuli chickpea genotypes including some varieties released in Tunisia have been characterized for different agromorphological traits in order to estimate variability levels between them. For this purpose a trial was conducted at Ariana in Tunisia. Univariate analysis showed high significant differences between genotypes for many traits. Principal Component Analysis was performed for all traits and allowed to define three axes that explain 68.4 % of the total traits variability. The first group is formed by genotypes ‘Bochra’, ‘Chetoui' and’ ‘line 5’. The second clustered genotypes ‘Kasseb’, ‘Neyer’, ‘Beja 1’and' Lineage 4. Genotypes ‘Line 3’ and ‘Line 6’ represent the third group, while the fourth group is formed by genotypes ‘Lineage 1’, ‘Lineage 2’,‘Amdoun 1’ and ‘Beja 2’. Genotypes could be classified in four groups by reference to the chosen axes. Genotypes forming the same group are closely related to each other according to their common morphological characters (the number of pod to 1 only seed, the number of days to maturity, the output in seeds by plant and with the size of pods.)
Evaporation and sublimation measurement and modeling of an alpine saline lake influenced by freeze–thaw on the Qinghai–Tibet Plateau

Abstract. Saline lakes on the Qinghai–Tibet Plateau (QTP) affect the regional climate and water cycle through water loss (E, evaporation under ice-free conditions and sublimation under ice-covered conditions). Due to the observational difficulty over lakes, E and its underlying driving forces are seldom studied when targeting saline lakes on the QTP, particularly during ice-covered periods (ICP). In this study, the E of Qinghai Lake (QHL) and its influencing factors during ice-free periods (IFP) and ICP were first quantified based on 6 years of observations. Subsequently, three models were calibrated and compared in simulating E during the IFP and ICP from 2003 to 2017. The annual E sum of QHL is 768.58±28.73 mm, and the E sum during the ICP reaches 175.22±45.98 mm, accounting for 23 % of the annual E sum. E is mainly controlled by the wind speed, vapor pressure difference, and air pressure during the IFP but is driven by the net radiation, the difference between the air and lake surface temperatures, the wind speed, and the ice coverage during the ICP. The mass transfer model simulates lake E well during the IFP, and the model based on energy achieves a good simulation during the ICP. Moreover, wind speed weakening resulted in an 7.56 % decrease in E during the ICP of 2003–2017. Our results highlight the importance of E in ICP, provide new insights into saline lake E in alpine regions, and can be used as a reference to further improve hydrological models of alpine lakes.
Monitoring of Microbial Pollution in the Lagos (Coastal) Lagoon, Nigeria

Lagos Lagoon, the largest coastal lagoon in West Africa covers an area of about 208 square kilometres. Its only opening to the sea is through the Commodore Channel which serves as the main entrance to Nigeria's largest seaports of Lagos and Tin Can Ports. The lagoon, is used mainly for artisanal fisheries, transportation by local communities and also serves as the ultimate sink for the disposal of untreated sewage and industrial effluents situated around the Lagos metropolis. A short term study was undertaken to determine the occurrence and levels of microbes in the Lagos lagoon. Routine bacteriological studies were made on the levels of Total Coliforms (TC), Faecal Coliforms (FC) and Faecal Streptococci (FS). Results of the study show that TC, FC, and FS count were high in Lagos lagoon water (maximum of 1800 + micro organisms per 100 ml). The concentration of organisms in coastal waters was low (Maximum of 220 micro organisms per 100ml).
Developing an English Language School Management Course: Curriculum Innovation and Entrepreneurial Opportunities at Universitas Negeri Makassar

This paper is based on a systematic literature review conducted to justify the introduction of a new course, 'English Language School Management' (ELSM), in the English Language Education Study Program (ELESP) at Universitas Negeri Makassar, Indonesia. The literature review involved a detailed analysis of academic sources relevant to English language education and management, identifying gaps in current academic discourse and practical educational needs in the post-Covid-19 context. Prompted by the implementation of the Merdeka Belajar Kampus Merdeka program, which necessitated curriculum revision, ELSM was developed. This course aims to provide ELESP students with critical insights into the operation and management of English language schools. These institutions are vital in non-formal education, as underutilized partners in teacher training programs, and as potential employment and entrepreneurial opportunities for graduates. The introduction of ELSM addresses a notable lack of focus on English language schools within Indonesian academic circles, despite their popularity and significant educational contributions. The development of this course is expected to enhance ELESP students' awareness of both the potential and challenges faced by English language schools, especially in the post-pandemic era.
An oncogene regulating chromatin favors response to immunotherapy

ABSTRACT Many biological processes related to cell function and fate begin with chromatin alterations, and many factors associated with the efficacy of immune checkpoint inhibitors (ICIs) are actually downstream events of chromatin alterations, such as genome changes, neoantigen production, and immune checkpoint expression. However, the influence of genes as chromatin regulators on the efficacy of ICIs remains elusive, especially in gastric cancer (GC). In this study, thirty out of 1593 genes regulating chromatin associated with a favorable prognosis were selected for GC. CHAF1A, a well-defined oncogene, was identified as the highest linkage hub gene. High CHAF1A expression were associated with microsatellite instability (MSI), high tumor mutation burden (TMB), high tumor neoantigen burden (TNB), high expressions of PD-L1 and immune effector genes, and live infiltration of immune cells. High CHAF1A expression indicated a favorable response and prognosis in immunotherapy of several cohorts, which was independent of MSI, TMB, TNB, PD-L1 expression, immune phenotype and transcriptome scoring, and improved patient selection based on these classic biomarkers. In vivo, CHAF1A knockdown alone inhibited tumor growth but it impaired the effect of an anti-PD-1 antibody by increasing the relative tumor proliferation rate and decreasing the survival benefit, potentially through the activation of TGF-β signaling. In conclusion, CHAF1A may be a novel biomarker for improving patient selection in immunotherapy.
Vitamin D level among patients with unexplained musculoskeletal symptoms

Background: Unexplained musculoskeletal (MSK) symptoms sometimes pose diagnostic and management challenges and can lead to prolonged suffering and disability. Hypovitaminosis D could be a reason for such symptoms. This study aimed to determine the vitamin D level among patients with unexplained MSK symptoms. Methods: A cross-sectional study was conducted in a private clinic of Chattogram city, Bangladesh. A total of 110 unexplained MSK patients were enrolled conveniently. MSK symptoms were assessed by rheumatologist and serum vitamin D levels were measured according to the standard laboratory procedure. Descriptive and logistic regression analyses were done. Principal component analysis was performed for the reduction of MSK symptoms. Results: The median (interquartile range) vitamin D level was 24.6 (20.0–29.0) ng/mL. Hypovitaminosis D (<30 ng/mL) was observed in 80.0% (95% CI: 71.3%–87.0%) respondents. Patients who had difficulty in climbing stairs, bone pain and muscle cramp had 79.8%, 84.9% and 79.8% hypovitaminosis D respectively. In logistic regression analysis, overweight defined by body mass index ≥25 kg/m2 (OR 5.5, 95% CI 1.7–17.4) was significantly associated with hypovitaminosis D. Conclusions: Hypovitaminosis D was common in patients with unexplained MSK symptoms and overweight was significantly associated with it. Further studies in representative samples are necessary.
Pesticides used in tobacco (Nicotiana tabacum) cultivation in Cuba: toxicological and ecotoxicological pressure

Introduction. Pesticides are used to control pests and diseases in agricultural activities. Improper handling of these products constitutes a potential risk to human health and the environment. Objective. To evaluate the toxicological (eco) pressure exerted by synthetic pesticides on tobacco (Nicotiana tabacum) crops in the province of Sancti Spíritus, Cuba. Materials and methods. A database of the Provincial Directorate of Plant Health for the period 2016-2019 was used, where the pesticides assigned to the province for this crop were taken and compared with those declared by the farmers interviewed. The dual indicator POCER was used to obtain the results, which determined the pressure exerted by the different pesticides and their harmful reference on humans and the environment. Results. The trend in pesticide consumption (summarized in tables and graphs) showed a decrease of 50 %, which corresponds to the country's crop protection policy. Farmers mentioned the use of authorised and unauthorized active ingredients in the surveys carried out. Sixteen high-risk active ingredients were detected in the samples analyzed. Evaluation of the POCER results and analyzed samples shows that there is a high (eco)toxicological pressure on both the environment and human health exerted by a group of highly toxic active ingredients used in tobacco cultivation in the province. Conclusion. With the use of the dual indicator POCER, an evaluation of the toxicological (eco) pressure exerted by the synthetic pesticides used in the cultivation of tobacco (Nicotiana tabacum) in the province of Sancti Spiritus, Cuba for the study period is obtained.
Risk factors for the development of bronchiolitis obliterans in children after suffering from adenovirus pneumonia

Introduction Bronchiolitis obliterans (BO) is an irreversible chronic obstructive lung disease in small airways. The aim of this study was to identify the relevant risk factors for the development of BO in children after suffering from adenovirus (ADV) pneumonia. Methods An observational cohort study that included 112 children suffering from ADV pneumonia in our institution from March 2019 to March 2020 was performed. We divided the children into a BO group and a non-BO group based on whether they did develop BO or not. Univariate analysis and multivariate logistic regression analysis were applied to identify risk factors for the development of BO. The prediction probability model was evaluated by receiver operating characteristic (ROC) curve analysis. Results Twenty-eight children (25%) did develop BO after suffering from ADV pneumonia, while 84 children did not. Respiratory support (OR 6.772, 95% CI 2.060–22.260, P = 0.002), extended length of wheezing days (OR 1.112, 95% CI 1.040–1.189, P = 0.002) and higher lactic dehydrogenase (LDH) levels (OR 1.002, 95% CI 1.000–1.003, P = 0.012) were independently associated with the development of BO. The predictive value of this prediction probability model was validated by the ROC curve, with an area under the curve of 0.870 (95% CI 0.801–0.939, P < 0.001), a standard error of 0.035, a maximum Youden's index of 0.608, a sensitivity of 0.929, and a specificity of 0.679. Conclusions After suffering an ADV pneumonia, children who have needed respiratory support, had a longer length of wheezing days or had higher LDH levels are more likely to develop BO.
Sea Turtles in Spanish Mediterranean Waters: Surprises in 2001

Articles: Sea Turtles in Spanish Mediterranean Waters: Surprises in 2001. Confirmed Leatherback Turtle (Dermochelys Coriacea) Nests from North Carolina, with a Summary of Leatherback Nesting Activities North of Florida. Monitoring Nesting Loggerhead Turtles (Caretta Caretta) in the Central Caribbean Coast of Colombia. Incidental Capture of Loggerhead Turtles (Caretta caretta) on Boa Vista (Cape Verde Islands). Observations on Sea Turtles in the State of Paraiba, Brazil. Epibiotic Associates of Oceanic-Stage Loggerhead Turtles from the Southeastern North Atlantic.
Rapamycin does not alter bone microarchitecture or material properties quality in young-adult and aged female C57BL/6 mice

Abstract Advancing age is the strongest risk factor for osteoporosis and skeletal fragility. Rapamycin is an FDA-approved immunosuppressant that inhibits the mechanistic target of rapamycin (mTOR) complex, extends lifespan, and protects against aging-related diseases in multiple species; however, the impact of rapamycin on skeletal tissue is incompletely understood. We evaluated the effects of a short-term, low-dosage, interval rapamycin treatment on bone microarchitecture and strength in young-adult (3 mo old) and aged female (20 mo old) C57BL/6 mice. Rapamycin (2 mg/kg body mass) was administered via intraperitoneal injection 1×/5 d for a duration of 8 wk; this treatment regimen has been shown to induce geroprotective effects while minimizing the side effects associated with higher rapamycin dosages and/or more frequent or prolonged delivery schedules. Aged femurs exhibited lower cancellous bone mineral density, volume, trabecular connectivity density and number, higher trabecular thickness and spacing, and lower cortical thickness compared to young-adult mice. Rapamycin had no impact on assessed microCT parameters. Flexural testing of the femur revealed that both yield strength and ultimate strength were lower in aged mice compared to young-adult mice. There were no effects of rapamycin on these or other measures of bone biomechanics. Age, but not rapamycin, altered local and global measures of bone turnover. These data demonstrate that short-term, low-dosage interval rapamycin treatment does not negatively or positively impact the skeleton of young-adult and aged mice.
The Media, Planning and the Oak

IntroductionThe role of the media with respect to urban planning has not been well-addressedin the existing body of planning literature. This article explores the topic through acase study of the Oak Ridges Moraine (ORM) planning issue in Canada. The casestudy analyses the Toronto Star’s coverage of the issue and knowledge gainedfrom interviews with actors intimately involved in the issue, including journalists,planners and members of environmental groups.How do people know which issues are important to them and the community atlarge? Society uses the information agencies, particularly the mass media, whichdeliver information and interpretations through the use of experts and news analysis.The media in turn are not simply conduits of information, as the journalists involvedmust make judgements about the selection and presentation of news to meet theirobligationstothecommunityinaresponsiblemanner(McCombsS Cohen, 1963; Harrison & Hoberg, 1991; McCombs S build uppublic images of political ﬁgures and current events; and inﬂuence whatindividuals should think about, know about and have opinions about. Thiscreates a type of learning process, in which the public discovers what is importantand needs to be addressed on the basis of how much emphasis the topic in questionis given in the information sources that they consult (Lang & Lang, 1959).
The Effect Of Indigofera Tinctoria Extract On Cdk5 Expression And Signs Of Inflammation In A Chronic Pain Rat Model

Chronic pain is a challenging case that requires efforts to find effective drugs with minimal side effects. In last decade, Cdk5 become a potential target of chronic pain traetment. Indigofera tinctoria is a plant that grows a lot in Indonesia and has been used for various purposes. This plant is proven to contain indirubin which was proven as a Cdk5 (Cycline dependent kinases 5) inhibitor. The Objective of this research is analyze the effect of Indigofera tinctoria in a chronic pain model. This research was involving 35 rats divided into 5 groups. CFA (Complete Freud’s Adjuvant) solution was injected into the right plantar area to make a chronic pain model. Indigofera tinctoria extract was given orally in 200 mg/KgBW (D1 group), 300 mg/KgBW (D2 group), and 400 mg/KgBW (D3 group). Treatment was given for 7 days after the sign of chronic inflammation were detected (28 days after CFA induction). The analgesic effect was determined by pain latency on the hotplate, the anti-inflammatory effect was evaluated by measuring the hind paw volume. The Cdk5 expression was detected at the dorsal root ganglia by immunohistochemistry method. Results: The mean pain latency value of the D2 and D3 groups was greater than that of the other groups. The inflammatory sign in the treatment group was smaller and significantly different than in the positive control group. Cdk5 expression is not statistically different, however, the treatment group showed a lower Cdk5 expression. Conclusions: Indigofera extract has potential analgesic, anti-inflammatory, and Cdk5 inhibitory effects.
Planejamento participativo e indução no turismo: Reflexões sobre a construção de redes de cooperação na ‘Região dos Negócios’ em Goiás (Brasil)

EnglishThis article highlights the importance of participation in tourism planning, with reference to the guidelines of the Tourism Regionalization Programme ‘Brazilian Routes’. The objective of this work is to analyse the participation of the city of Goiânia, as the inductor of the establishment of cooperation networks among the cities which constitute the so-called ‘Business Region’ in the State of Goias. To carry out this research, the technique of data triangulation was applied, by analysing written documents on the politics of tourism regionalization and interviewing key players in the process of regionalized tourism planning in Brazil, in Goias and in the cities of the ‘Business Region’. Results show that the Tourism Regionalization Programme is not enough for the construction of a participatory planning in tourism; thus, and previously to this process, it also necessary that all cities involved have properly identified the intentionality of their participation and have dialogued on behalf of it. portuguesEste artigo destaca a importância da participacao no planejamento do turismo, conforme as diretrizes do Programa de Regionalizacao do Turismo (PRT) ‘Roteiros do Brasil’. O objetivo deste trabalho e analisar a participacao do municipio de Goiânia, enquanto indutor do processo construcao de redes de cooperacao entre as cidades que constituem a chamada ‘Regiao dos Negocios’ no Estado de Goias. Para a realizacao dessa pesquisa aplicou-se a tecnica da triangulacao de dados em documentos relativos a politica de regionalizacao do turismo e realizou-se entrevistas com atores-chave do processo de planejamento regionalizado do turismo no Brasil, em Goias e nos municipios que compoem a ‘Regiao dos Negocios’. Com a analise dos resultados, chegou-se a conclusao de que o PRT nao e suficiente para a construcao de um planejamento participativo no turismo, sendo necessario tambem, antes desse processo, que os municipios envolvidos tenham identificado a intencionalidade da participacao e estejam dialogando em prol dela.
Case Series Study on Recovery of Left Ventricle Systolic Function After Percutaneous Coronary Intervention In ST-Segment Elevation Myocardial Infarction Patients at FMIC Hospital in Kabul, Afghanistan.

Background Left ventricle dysfunction is the most recurrent consequence of ST-elevated myocardial infarction, and still, it is a powerful predictor of mortality. The percutaneous coronary intervention of the culprit artery disease in acute coronary syndrome is related to a significant improvement of left ventricle segmental function. It is a retrospective case series study on a patient population with the diagnosis of ST-elevated myocardial infarction patients who presented to the hospital within 12 hours and underwent percutaneous coronary intervention at the French Medical Institute of Mother and Children Hospital. Data was collected retrospectively from the patient's medical record files and analyzed. We took the patients with Left ventricle dysfunction on echocardiography on the first presentation before percutaneous coronary intervention and saw the left ventricle function after three months of follow-up. We reviewed the charts of 102 patients (78.4% male and 21.6% female) with a diagnosis of St-elevated myocardial infarction who presented within 12 hours of chest pain. Of 102 patients, 55.9% had hypertension, 21.6% diabetes, 22.5% dyslipidemia, and 19.6% history of smoking, and their mean age was 58.11 ± 11.993 years. We noticed that percutaneous coronary intervention led to significant left ventricle dysfunction improvement in the patient population with ST-elevated myocardial infarction who presented within 12 hours of chest pain.