Miracle-dz/UniFAR-FTUs huggingface dataset:
Radiomics and Artificial Intelligence in Radiotheranostics: A Review of Applications for Radioligands Targeting Somatostatin Receptors and Prostate-Specific Membrane Antigens

Radiotheranostics refers to the pairing of radioactive imaging biomarkers with radioactive therapeutic compounds that deliver ionizing radiation. Given the introduction of very promising radiopharmaceuticals, the radiotheranostics approach is creating a novel paradigm in personalized, targeted radionuclide therapies (TRTs), also known as radiopharmaceuticals (RPTs). Radiotherapeutic pairs targeting somatostatin receptors (SSTR) and prostate-specific membrane antigens (PSMA) are increasingly being used to diagnose and treat patients with metastatic neuroendocrine tumors (NETs) and prostate cancer. In parallel, radiomics and artificial intelligence (AI), as important areas in quantitative image analysis, are paving the way for significantly enhanced workflows in diagnostic and theranostic fields, from data and image processing to clinical decision support, improving patient selection, personalized treatment strategies, response prediction, and prognostication. Furthermore, AI has the potential for tremendous effectiveness in patient dosimetry which copes with complex and time-consuming tasks in the RPT workflow. The present work provides a comprehensive overview of radiomics and AI application in radiotheranostics, focusing on pairs of SSTR- or PSMA-targeting radioligands, describing the fundamental concepts and specific imaging/treatment features. Our review includes ligands radiolabeled by 68Ga, 18F, 177Lu, 64Cu, 90Y, and 225Ac. Specifically, contributions via radiomics and AI towards improved image acquisition, reconstruction, treatment response, segmentation, restaging, lesion classification, dose prediction, and estimation as well as ongoing developments and future directions are discussed.
Development and distribution of palsas in Finnmark, Northern Norway, for the period 1950s to 2010s

Palsas are permafrost mounds in mires with a core of ice, widespread situated in the sporadic permafrost zone. A tendency towards decay of palsa mires since the second half of the 20 th century has been observed in Fennoscandia. This thesis is investigating the lateral changes and the distribution of palsas in Finnmark by utilizing multiple aerial images from 1950s onwards and by Geomorphological Distribution Modelling. Aerial images in a north-south transect from Lakselv, Suossjavri and Goatheluoppal reveal a total decrease in areas of palsas by 48 %, 33 % and 71 %, respectively, wherease the rate of degradation has increased since the start of 2000. Signs of degradation on aerial images from the 1950s suggest that the tendency of decay started at latest in the 1950s, and probably already from the warming period in the 1920s-1930s. The most important factors for the increase in rate of degradation are most likely the increase in both temperature and precipitation observed in the last few decades. By utilizing Generalized Linear Model, the probability of presence of palsas increase with 1) decreasing freezing degree days, 2) a humped (nonlinear) curve of thawing degree days, 3) decreasing mean annual precipitation, 4) increasing mean summer precipitation, 5) increasing area of mire and 6) a humped (nonlinear) curve of area of water. Hierarchical Partitioning indicates that the climate variables are the most important group of variables to independently explain the distribution of palsas. The total area of palsas in Finnmark in 2010 based on GDM and aerial images is estimated to be roughly 0.3 % of the total area of Finnmark. By utilizing the degradation rate and the total area of palsas in Finnmark, the total amount of potential carbon gas release in form of CH4 from decay of palsas from 1960 to 2010 was estimated to be less than three times as much as the human emissions of CH4 in Finnmark for one year (2010), and thus of rather minor importance in the global carbon cycle.
Geometric approach to vertex‐degree‐based topological indices–Elliptic Sombor index, theory and application

A novel geometric method is proposed for constructing vertex‐degree‐based molecular structure descriptors (topological indices). The model is based on an ellipse whose focal points represent the degrees of a pair of adjacent vertices. This approach enables a geometric interpretation of several previously known topological indices, and lead to design of a few new. The area of the ellipse induces a vertex‐degree‐based topological index of remarkable simplicity, which we call elliptic Sombor index(). The main mathematical properties of are established, especially its relations to other, earlier known, indices. Then the applicative potential of is analyzed.
Mapping of hydrocarbons and H3+ emissions at Jupiter's north pole using Galileo/NIMS data

In this paper we report the mapping of H3+, C2H2, and CH4 as derived by an unexploited Galileo/Near‐Infrared Mapping Spectrometer (NIMS) data set. As previously observed, hydrocarbons emissions appear to be located in the internal part of the auroral main oval, where CH4 3 µm vibrational band intensity ratios suggest that nonthermal excitation mechanisms, such as auroral particle precipitation and/or Joule heating, are responsible for the observed emissions. Temperature estimation are in good agreement for the CH4‐emitting region on the hot spot, while the values obtained for H3+ are lower in comparison with Cassini/visual and infrared mapping spectrometer and ground‐based data. C2H2 emission overlaps the CH4 one only at higher latitudes >75°N, indicating that different energetic particles are at work inside the main oval polar ward. CH4 is also found on the northern section of the main oval (135°< longitude <190°, 60°< latitude <90°N). The present investigation results have implications on the Juno/Jovian InfraRed Auroral Mapper observation planning as well as on the codes that will be used to retrieve temperatures and densities of all the emitting species involved in the Jupiter auroral processes.
Looking for the causes of and solutions to the issue of honey bee colony losses

Abstract Colony losses, including those induced by the colony collapse disorder, are an urgent problem of contemporary apiculture which has been capturing the attention of both apiculturists and the research community. CCD is characterized by the absence of adult dead bees in the hive in which few workers and a queen remain, the ratio between the brood quantity and the number of workers is heavily disturbed in favor of the former, and more than enough food is present. Robbing behavior and pests usually attacking the weakened colony do not occur. In the present paper, the causes of the emergence of this problem are discussed, as well as the measures of its prevention. The following factors, which lead to colony losses, are analyzed: shortage of high-quality food (pollen and honey); infestation with parasites, primarily with Varroa destructor, and mixed virus infections; bacterial infections (American and European foulbrood), fungal infections (nosemosis and ascosphaerosis) and trypanosomal infections (lotmariosis); and, finally, general management of the apiary. Certain preventive measures are proposed: (1) providing ample high-quality forage and clean water, (2) avoiding sugarisation, i.e. superfluous use of sugar syrup, (3) meeting the nutritional needs of the colony, (4) when feeding bees, taking care of the timing and the composition of diet, avoiding pure sugar syrup which in excessive quantities may induce energetic and oxidative stress, (5) when there is a shortage of natural feed – honey in the brood chamber – use sugar syrup with natural/artificial supplements to avoid protein starvation, (6) organized control of V. destructor in the colonies is obligatory due to its vector role, and (7) compliance with hygienic and sanitary measures and principles of good apiculture practice and management in apiaries. To conclude, all preventive measures are feasible in compliance with rules and regulations concerning regular spring and autumn bee health monitoring by licensed veterinarians, who can propose adequate treatments if necessary.
Influence of the tian shan on arid extratropical Asia

AbstractArid extratropical Asia (AEA) is bisected at the wetter Tian Shan (a northern offshoot of the Tibetan Plateau) into east and west deserts, each with unique climatological characteristics. The east deserts (~35°–55°N, ~75°–115°E) have a summer precipitation maximum, and the west deserts (~35°–55°N, ~45°–75°E) have a winter–spring precipitation maximum. A new high-resolution (50 km atmosphere–land) global coupled climate model is run with the Tian Shan removed to determine whether these mountains are responsible for the climatological east–west differentiation of AEA. Multicentennial simulations for the Control and NoTianshan runs highlight statistically significant effects of the Tian Shan. Overall, the Tian Shan are found to enhance the precipitation seasonality gradient across AEA, mostly through altering the east deserts. The Tian Shan dramatically change the precipitation seasonality of the Taklimakan Desert directly to its east (the driest part of AEA) by blocking west winter precipitation, en.
Grounding line variability and subglacial lake drainage on Pine Island Glacier, Antarctica

We produced a 6 year time series of differential tidal displacement for Pine Island Ice Shelf, Antarctica, using speckle‐tracking methods applied to fine‐resolution TerraSAR‐X data. These results reveal that the main grounding line has maintained a relatively steady position over the last 6 years, following the speedup that terminated in ~2009. In the middle of the shelf, there are grounded spots that migrate downstream over the 6 year record. Examination of high‐resolution digital elevation models reveals that these grounded spots form where deep keels (thickness anomalies) advect over an approximately flow‐parallel bathymetric high, maintaining intermittent contact with the bed. These data sets also reveal several subsidence and uplift events associated with subglacial lake drainages in the fast‐flowing region above the grounding line. Although these drainages approximately double the rate of subglacial water flow over periods of a few weeks, they have no discernible effect on horizontal flow speed.
Antibacterial Activity and Irritation Potential of Selected Essential Oil Components – Structure-Activity Relationship

A selection of structurally diverse components of essential oils was subjected to an antibacterial screening against the Gram-positive bacteria Staphylococcus aureus and Streptococcus pneumoniae as well as the Gram-negative bacteria Escherichia coli and Haemophilus influenzae using a broth microdilution method. In addition, the irritation potential of these substances to mucous membranes was evaluated by a modified HET-CAM (Hen's Egg Test-Chorioallantoic Membrane) assay. Minimum inhibitory concentrations (MIC) and irritation threshold concentrations (ITC) were compared in order to identify substances with a low mucous membrane irritation potential at the antibacterially effective concentration. Regarding the antibacterial activity, the most active substances were cinnamaldehyde, phenols, monoterpene alcohols and aldehydes. Oxygenated monoterpenes and phenylpropanoids without either alcohol or aldehyde function (ethers, ketones) showed moderate activity. Mono- and sesquiterpene hydrocarbons, as well as sesquiterpene alcohols, were more or less inactive against most of the bacteria tested, with the exception of Streptococcus pneumoniae whose growth was inhibited by sesquiterpenes at exceptionally low concentrations. In most cases, the irritation potential of the test compounds could also be traced back to their structural features. 2-Phenylethanol, monoterpene alcohols, phenols and aromatic aldehydes had the lowest ITC-values, followed by monoterpene aldehydes, ketones and ethers. In contrast, monoterpene hydrocarbons caused irritation only at higher doses. Of special interest was the fact that all the sesquiterpenes tested were not irritant even when applied undiluted to the chorioallantoic membrane (CAM).
CHILD LABOR EXPLOITATION AND CHILDREN'S PARTICIPATION IN EDUCATION: A STUDY IN SELECTED PRIMARY SCHOOLS AT DEBUBE OMO ZONE

As is the case with other developing countries of the world, child labor is also a problem in Ethiopia. Child labor is mainly caused by poverty and the socio-cultural perspectives of society, where inhabitants require the labor of their children for household tasks and agricultural activities than sending them to school. The study was conducted to assess the general situation of child labor exploitation and children's participation in primary education in selected primary schools at Debub Omo Zone and thereby to recommend mechanisms to alleviate the problem. This study has used both primary and secondary data sources. The methods used to collect primary data include: in depth-interview, focus group discussion, and observation. Informants were selected by purposive and available sampling techniques based on variables: age, sex, religion, education, occupation and marital status and a total of 58 informants participated in the study. Findings of the study revealed that child labor became a major problem in the study area, where it is closely associated with poverty and socio-cultural viewpoint of the society, which value children as an economic asset of their families. As a result of this, children were forced to drop their schooling or not got the chance to go to school. As the study reveals, children were expected to perform both domestic activities (such as cooking, fetching water and fire wood, caring siblings and washing) and productive activities (like cultivating, planting, weeding, harvesting, and keeping cattle and goats). The finding also indicates that child labor affects the physical, social, emotional, educational and health conditions of the working child. Therefore, it needs collaborative effort of all governmental, non-governmental and family's effort in the fight against child labor, so as to ensure children's school participation.
Morphological characterization of Brinjal genotype of Assam using multivariate analysis

The experiment was carried out to evaluate the genetic diversity, correlation, and path coef�icient analysis between twenty-three brinjal genotypes during the summer season of 2019 at Horticultural Research Farm, Assam Agricultural University. The twenty-three brinjal genotypes were grown in randomized complete block design with three replications. The analyses of variance revealed signi�icant variation at a genotypic level for all the sixteen characters except one i.e, fruit length which indicates that the genotypes are diverged genetically. Longai oblong (G3) genotype has shown the maximum yield per plant, which may be due to the highest number of primary branches. From the path coef�icient analysis, it was found that the highest positive direct eﬀect was of days to 50% fruiting (1.100), followed by days to �irst fruiting (0.263), fruit volume (0.217), days to 50% �lowering (0.199) and fruit pedicel length (0.190). For these characters, direct selection would be useful in crop 2 improvement. Based on D analysis the twenty-three genotypes were grouped into 5 clusters. 2 The inter-cluster D value was observed to be maximum (329.67) between clusters III and IV 2 followed by between cluster I and IV with D value of 284.76. This is indicative of diverse clusters which can be utilized for producing superior heterotic combinations. The values of the PCs explained all the characters in�luencing about 77.6% of the genotypic variability, while the �irst two PCs explained 58.8% of the variability. Based on the relationship of characters and genotypes to the PC 1, it can be concluded that the genotypes G3, G5, G7, G10, and G19 can be selected for breeding purposes in the brinjal improvement program for the Assam condition.
Focus on Mitochondrial Respiratory Chain: Potential Therapeutic Target for Chronic Renal Failure

The function of the respiratory chain is closely associated with kidney function, and the dysfunction of the respiratory chain is a primary pathophysiological change in chronic kidney failure. The incidence of chronic kidney failure caused by defects in respiratory-chain-related genes has frequently been overlooked. Correcting abnormal metabolic reprogramming, rescuing the “toxic respiratory chain”, and targeting the clearance of mitochondrial reactive oxygen species are potential therapies for treating chronic kidney failure. These treatments have shown promising results in slowing fibrosis and inflammation progression and improving kidney function in various animal models of chronic kidney failure and patients with chronic kidney disease (CKD). The mitochondrial respiratory chain is a key target worthy of attention in the treatment of chronic kidney failure. This review integrated research related to the mitochondrial respiratory chain and chronic kidney failure, primarily elucidating the pathological status of the mitochondrial respiratory chain in chronic kidney failure and potential therapeutic drugs. It provided new ideas for the treatment of kidney failure and promoted the development of drugs targeting the mitochondrial respiratory chain.
The relationship between critical life events, psycho-emotional health and life satisfaction among youths: coping mechanisms and emotional regulation

Objective Several studies in the specialized literature have reported that events such as the death of a loved one, job loss, divorce, illness, or retirement lead to an increase in the level of stress felt, and subsequently stress affects the person on several levels of life, such as: personal, relational, social, academic and at the same time sanogenic. The present paper explored the relationship between critical life events and psycho-emotional health among youths and the manner in which this relationship is mediated by the level of life satisfaction. Methods The data was extracted using a sample of participants (between 20 and 40 years old) from several cities in Romania, who experienced one or more critical life events during the last year. Data organization and hypothesis testing were performed using IBM SPSS 23 and jamovi programs. For this purpose we used the simple regression analysis, Pearson correlation and mediation analysis. The scales used to conduct the research were: RS-14, SRRS, ERQ, CERQ, DASS-21 and SWLS. Results The final sample of the study totaled 190 female and male Romanian participants aged between 20 and 40 (M = 24.45, SD = 5.27) who had experienced critical events during the last year, leading to psycho-emotional destabilization and a significantly lower level of life satisfaction. The prevalence of critical life events among these participants varied from one to five events (55.26%) and up to more than 16 critical events in the past year (2.63%). The presence of these events led to increased levels of stress, anxiety, or depression among participants. Furthermore, it appears that the presence of a high number of critical life events led to a decreased life satisfaction among participants, along with a greater tendency toward catastrophizing. Conclusion Critical life events are increasingly frequent events in everyday life, and youth seems to be the period with the most changes. The research findings add to current findings about the practical implications that critical life events have on psycho-emotional health among youths. Therefore it appears to be a close relationship between critical life events, psycho-emotional health, and emotional regulation. At the same time, it seems that coping mechanisms have a central role in the level of life satisfaction among youths.
The Psychological Impact on Parents of Children who Receive an Inconclusive Diagnosis for Cystic Fibrosis following Newborn Screening: A Systematic Mini-Review

Newborn screening (NBS) has been available for the diagnosis of cystic fibrosis (CF) over the last decades. Through the implementation of NBS, a new designation emerged, that of CF related metabolic syndrome (CRMS) or cystic fibrosis screen positive inconclusive diagnosis (CFSPID). As there is uncertainty regarding the clinical progression of these infants to CF, some studies have investigated the psychological impact of CRMS/CFSPID on their parents. This systematic narrative review aimed to describe the findings of the relevant studies. The number of studies is limited and the study samples are relatively small. It seems that there is a negative impact of CRMS/CFSPID on parental mental health. While some studies indicated similar levels of parental anxiety among those with infants diagnosed with CF and those with CRMS/CFSPID, not all studies reached the same conclusion. Parental uncertainty represents another mental dimension of the impact associated with the designation of CRMS/CFSPID. These observations suggest that parents of infants with CRMS/CFSPID should be provided with effective communication, and it may also be beneficial to consider parental mental screening. More robust and long-term studies are required to detect differences in parental emotional status between those with infants diagnosed with CF and those with CRMS/CFSPID.
Analytical model of green-blue connectivity in the metropolitan area of Bucharest

: Planning for a green-blue infrastructure contributes to protecting nature and improving the quality of urban life by supporting the ecological, economic and social functions of urban areas. The European Commission states that there is no need for legislation designed exclusively to enforce implementing the concept of green-blue infrastructure in European countries and calls instead for using existing legislation, policy instruments and funding mechanisms. For the effective conservation of biodiversity, territorial planning at any spatial level must be an indispensable tool, especially for a country like Romania, where nature conservation yields almost always to economic development. Therefore, the main objective of our study is developing and implementing an innovative methodology for delimiting green-blue areas and ecological corridors in Bucharest metropolitan area and its integration into national policies and strategies. The methodology for developing the green-blue infrastructure plan is based on European, local and regional data, GIS tools, and urban planning solutions. The results of this study represent a realistic connectivity analysis, which contributes to planning for the green-blue infrastructure within the Urban Plan of Bucharest. As the main conclusion, we mention the need to protect the metropolitan territory of big cities from the intensity and dispersion of urban development.