Miracle-dz/UniFAR-FTUs huggingface dataset:
PENERAPAN METODE ANALYTIC HIERARCHY PROCESS UNTUK MERUMUSKAN STRATEGI PENGUATAN KINERJA SISTEM AGRIBISNIS CABAI MERAH DI KABUPATEN TEMANGGUNG

Kinerja agribisnis yang baik dipengaruhi oleh pembangunan subsektor agribisnis hulu, subsektor pertanian primer, subsektor agribisnis hilir dan subsektor jasa penunjang secara simultan dan harmonis. Penelitian ini bertujuan untuk merumuskan strategi penguatan kinerja agribisnis cabai merah di kabupaten Temanggung. Pemilihan daerah dilakukan secara purposive di kecamatan Bulu dan Tlogomulyo, kabupaten Temanggung. Penelitian dilakukan pada bulan Desember 2010 dengan menggunakan pendekatan focused grup discussion (FGD) dan wawancara yang melibatkan 15 orang keypersons. Penelitian ini menggunakan Teknik analisis deskriptif kuantitatif dan analytic hierarchy Process (AHP). Hasil analisis AHP menunjukkan bahwa terdapat tiga prioritas utama yang perlu dilaksanakan dalam strategi penguatan kinerja agribisnis cabai merah di Kabupaten Temanggung adalah penyediaan dan akses modal yang diperuntukkan bagi usahatani cabai merah, pendampingan penerapan teknologi budidaya yang tepat kepada petani, dan pemerintah menyediakan sarana pasar agro yang bisa menampung hasil budidaya hortikultura di kabupaten Temanggung
Genome-wide association study of Yunnan-specific wheat varieties under conditions of drought stress

Drought is associated with serious declines in crop yield. In this study, we investigated and analyzed the effect of drought on wheat yields. We considered 263,742 single nucleotide polymorphisms (SNPs) obtained from genotyping-bysequencing (GBS) and a genome-wide association study (GWAS) using PH (plant height), DTM (days to maturity), TGW (thousand grain weight), NGS (number of grains per spike), EL (ear length), FLL (flag leaf length), and FLW (flag leaf width) as indices. We identified 60 significant SNPs associated with EL, 41 with PH, 24 with DTM, 17 with FLL, 5 each with NGS and FLW, and 3 with TGW. We further identified 77 putative and potential genes within 100 kb from the major SNPs. We found that these genes encode transcription factors and hormones and are involved in enzyme activity, transmembrane transport, signal transduction, epidermal wax synthesis, metabolism, growth and development, pigment, stomata, root hairs, and stress tolerance. Collectively, our results provide valuable insights into the genetic basis of drought resistance in bread wheat. Further studies that predict candidate genes will help interpret the drought resistance mechanism of wheat, and aid the selection and breeding of drought-resistant wheat varieties suitable for different environmental conditions.
Effect of barium titanate particle filler on the performance of polyurethane-based dielectric elastomer actuators

Electroactive polymers are a major component of dielectric elastomer actuators (DEA). The performance of DEAs depends on the Young’s modulus, dielectric constant and film thickness of the electroactive polymer as well as the compliance of the electrodes and the applied voltage. In literature mostly experiments on silicone- and acrylic-based DEAs are reported. However, better actuator performance can be expected with materials that have a higher dielectric constant. Therefore, unconventional electroactive polymers, such as polyurethane, chloroprene, or nitrile rubber, are currently attracting increasing interest for DEA applications. Besides their inherent dielectric properties, ferroelectric fillers embedded in the electroactive polymer can increase the dielectric constant even further. Provided that the filler concentration does not significantly increase the Young’s modulus, ferroelectrically filled polymers can be expected to have a better actuator performance than standard materials. In this work, barium titanate particles with different concentrations were embedded in crosslinked polyurethane elastomer films. The hyperelastic material behavior of the polyurethane elastomer is represented by a Mooney-Rivlin model. Impedance spectroscopy is used to determine the dielectric constant of the electroactive compounds. Planar DEAs are designed from both unfilled and barium titanate-filled polyurethane films and compared with respect to their mechanical, dielectric, and actuator properties. The electric field response of unfilled and barium titanate-filled polyurethane-based DEAs is investigated experimentally and compared to an analytical solution of the actuator deformation. Additionally, a comparison between experimental DEA operation and an FEA prediction is carried out and discussed.
The Effect of Sleep–Wake Routines on the Negative Emotional States and Aggressive Behaviors in Adults with Autism Spectrum Disorders (ASD) during the COVID-19 Outbreak

Disruption in routine may be related to experiencing negative emotional states and to aggressive behaviors in individuals with Autism Spectrum Disorder (ASD). The lockdown because of COVID-19 contributed to the disruption of individuals’ routines, including the sleep–wake cycle. The current study tested a relationship between the adherence to the sleep–wake routine and aggressive behaviors via the mediation role of negative emotional states (i.e., anxiety and anger). Forty-three parents of adults with ASD completed a web-based questionnaire about their life condition during the first lockdown (April–May 2020). Preliminary analyses showed a worsening in the adults’ aggressive behaviors during the lockdown in comparison to before it (Z = −3.130; p = 0.002). In the mediation models, the relationship between the adherence to the sleep–wake routines and aggressive behaviors was significant. The models showed the hypothesized mediated relationships among the adherence to the sleep–wake routines, negative emotional states, and aggressive behaviors (Model 1: F (1, 41) = 10.478, p < 0.001; Model 2: F(1, 41) = 9.826, p = 0.003). The findings confirmed the potential protective role of the adherence to the sleep–wake routines for the emotional and behavioral adjustment of adults with autism. Theoretical and practical contributions of the study were discussed; indeed, our results may inform parent-coaching as well as intervention programs for individuals with ASD given that adequate sleep hygiene may contribute to improvements in internalizing/externalizing behaviors.
Rap1a Activity Elevated the Impact of Endogenous AGEs in Diabetic Collagen to Stimulate Increased Myofibroblast Transition and Oxidative Stress

Diabetics have an increased risk for heart failure due to cardiac fibroblast functional changes occurring as a result of AGE/RAGE signaling. Advanced glycation end products (AGEs) levels are higher in diabetics and stimulate elevated RAGE (receptor for AGE) signaling. AGE/RAGE signaling can alter the expression of proteins linked to extracellular matrix (ECM) remodeling and oxidative stressors. Our lab has identified a small GTPase, Rap1a, that may overlap the AGE/RAGE signaling pathway. We sought to determine the role Rap1a plays in mediating AGE/RAGE changes and to assess the impact of isolated collagen on further altering these changes. Primary cardiac fibroblasts from non-diabetic and diabetic mice with and without RAGE expression and from mice lacking Rap1a were cultured on tail collagen extracted from non-diabetic or diabetic mice, and in addition, cells were treated with Rap1a activator, EPAC. Protein analyses were performed for changes in RAGE-associated signaling proteins (RAGE, PKC-ζ, ERK1/2) and downstream RAGE signaling outcomes (α-SMA, NF-κB, SOD-2). Increased levels of endogenous AGEs within the diabetic collagen and increased Rap1a activity promoted myofibroblast transition and oxidative stress, suggesting Rap1a activity elevated the impact of AGEs in the diabetic ECM to stimulate myofibroblast transition and oxidative stress.
Cyberbullying in first-year university students and its influence on their intentions to drop out

ABSTRACT University dropout is a phenomenon of growing interest in the knowledge society. However, it is a complex phenomenon in which a variety of academic and social variables interact with each other. Cyberbullying is also something that has been the subject of increased research recently, and although it has most often been studied in primary and secondary education, it cannot be discounted from higher education. Because of that, the objective of this study was to determine whether there was a relationship between intentions to complete higher education or not and having been the victim of cyberbullying. We used a sample of 1653 students at a university in Spain who were asked to respond to an adaptation of the University Violence Questionnaire (UVC), analysing the data collected via descriptive statistics and the decision tree test. The results indicated that there was a relationship between having been the victim of cyberbullying and the intention to drop out of a university course, especially when the bullying behavior was social exclusion, impersonation, or spreading sexual images without consent. This study aimed to enhance understanding of university dropout, looking at how being the victim of cyberbullying interacted with the likelihood of students finishing their courses.
Calcium-Rich Pigeonpea Seed Coat: A Potential Byproduct for Food and Pharmaceutical Industries

Pigeonpea is a protein-rich legume which is consumed worldwide in a variety of forms (whole seed, dhal, and as a green vegetable). In India, pigeonpea is milled to yield dhal (cotyledon) and this process generates 25–35% waste byproducts. The hull (seed coat) which accounts for 10% of the byproduct is disposed of either as waste or low-cost cattle feed. To recycle the waste byproducts into the food value chain, this study was conducted with the objectives: (i) to estimate nutrient accumulation in the major seed fractions (cotyledon and seed coat), (ii) to estimate the percentage of nutrient contribution by major seed fractions, (iii) to assess the percentage of nutrient loss due to dehulling, and (iv) to determine the scope of seed coat in nutritional value addition. For this, a subset of 60 diverse pigeonpea accessions selected from 600 pigeonpea accessions raised during the 2019 and 2020 rainy seasons at ICRISAT, Patancheru, India, was subjected to a cotyledon and seed coat nutrient analysis. The three-way analysis of variance revealed the significant influence of cropping years, seed fractions, genotypes, and their interactions on nutrient accumulation. The nutrients, namely protein (32.28 ± 2.29%), P (476.51 ± 39.05 mg/100 g), K (1557.73 ± 66.82 mg/100 g), Fe (4.42 ± 0.41 mg/100 g), Zn (2.25 ± 0.21 mg/100 g), and Cu (0.95 ± 0.07 mg/100 g) were enriched in cotyledon. Mn was equally enriched in both the cotyledon and seed coat (1.02 ± 0.12 mg/100 g and 0.97 ± 0.34 mg/100 g, respectively). The seed coat had a high concentration of Ca (652.02 ± 114.82 mg/100 g), and Mg (249.19 ± 34.12 mg/100 g) with wide variability for Fe (2.74–5.61 mg/100 g), Zn (0.88–3.95 mg/100 g), Cu (0.38–1.44 mg/100 g), and Mn (0.58–2.18 mg/100 g). It is noteworthy that the protein and P contents in the cotyledon were 7 and 18 times higher than that in the seed coat, respectively, and the Ca content in the seed coat was 12 times higher than that in the cotyledon. A correlation study revealed that for overall nutrient improvement in dhal, selection for a small seed size was desirable. On an average, the percentage of nutrient contribution by major seed fractions revealed that the cotyledon portion contributed around 95% protein and P; 90% K and Zn; 85% Fe, Cu, and Mn; and 75% Mg, while the seed coat portion contributed nearly 65% Ca to the whole grain. The findings of high Fe and protein concentrations in the cotyledon and high Ca accumulation in the seed coat can serve as a new guide for improved technological fractionation of these components to serve as a novel functional food ingredient and as a dietary supplement that can address malnutrition.
Determinants of blockchain adoption as decentralized business model by Spanish firms - an innovation theory perspective

PurposeLarge attention surrounds identifying the meaningful blockchain business model on financial services, while a little focus about non-financial organizations and solutions in terms of how the blockchain business model can affect the organization and bring more value. To address the complex structure of businesses that have public goods, it is important to develop sustainable blockchain-based business models.Design/methodology/approachThis study offers the first qualitative research that uses an integrated technological, environmental and organizational (TOE) framework with technology acceptance theory (TAM) to study the adoption of blockchain technology by Spanish firms.FindingsThe results of the paper discuss how that competitive pressure, competence, top management support and relative advantage have a positive impact on intention to adopt blockchain technology while complexity affects the intention to adopt the technology negatively. Contrary to many adoption studies, the findings show that intention to adopt negatively impacts adoption and outline the effect of blockchain on business model elements on the macroeconomic level.Originality/valueThe key contribution of this study lies in providing a comprehensive understanding of the environmental, technological and organizational factors that impact the intention to adopt blockchain that eventually affects adoption.
Sphingolipids and Lymphomas: A Double-Edged Sword

Simple Summary Cancer is an incredibly smart disease, so much so that it can entirely reprogram our cells’ metabolism to ensure its survival and dissemination. Lymphomas are a particularly interesting group of cancers because they are very diverse and exhibit complex pathogenic mechanisms that can make them clinically challenging. Many of these mechanisms involve the dysregulation of a biologically relevant family of lipids known as sphingolipids. These molecules are involved in virtually every cellular process and therefore studying them in this context is crucial. However, sphingolipid biochemistry is intricate and the synergistic and antagonic effects of different sphingolipid species with one another has long puzzled scientists. This duality is also observed in cancer, but research specifically focusing on lymphomas is limited. Could novel biomarkers and therapies against lymphomas be hiding within this pathway? Abstract Lymphomas are a highly heterogeneous group of hematological neoplasms. Given their ethiopathogenic complexity, their classification and management can become difficult tasks; therefore, new approaches are continuously being sought. Metabolic reprogramming at the lipid level is a hot topic in cancer research, and sphingolipidomics has gained particular focus in this area due to the bioactive nature of molecules such as sphingoid bases, sphingosine-1-phosphate, ceramides, sphingomyelin, cerebrosides, globosides, and gangliosides. Sphingolipid metabolism has become especially exciting because they are involved in virtually every cellular process through an extremely intricate metabolic web; in fact, no two sphingolipids share the same fate. Unsurprisingly, a disruption at this level is a recurrent mechanism in lymphomagenesis, dissemination, and chemoresistance, which means potential biomarkers and therapeutical targets might be hiding within these pathways. Many comprehensive reviews describing their role in cancer exist, but because most research has been conducted in solid malignancies, evidence in lymphomagenesis is somewhat limited. In this review, we summarize key aspects of sphingolipid biochemistry and discuss their known impact in cancer biology, with a particular focus on lymphomas and possible therapeutical strategies against them.
Decision-Makers' Understanding of Cyber-Security's Systemic and Dynamic Complexity: Insights from a Board Game for Bank Managers

Cyber-security incidents show how difficult it is to make optimal strategic decisions in such a complex environment. Given that it is hard for researchers to observe organisations’ decision-making processes driving cyber-security strategy, we developed a board game that mimics this real-life environment and shows the challenges of decision-making. We observed cyber-security experts participating in the game. The results showed that decision-makers who performed poorly tended to employ heuristics, leading to fallacious decision approaches (overreaction strategies in place of proactive ones), and were not always aware of their poor performances. We advocate the need for decision support tools that capture this complex dynamic nature.
Sex Differences in VO2max and the Impact on Endurance-Exercise Performance

It was not until 1984 that women were permitted to compete in the Olympic marathon. Today, more women than men participate in road racing in all distances except the marathon where participation is near equal. From the period of 1985 to 2004, the women’s marathon record improved at a rate three times greater than men’s. This has led many to question whether women are capable of surpassing men despite the fact that there remains a 10–12% performance gap in all distance events. The progressive developments in sports performance research and training, beginning with A.V. Hill’s establishment of the concept of VO2max, have allowed endurance athletes to continue performance feats previously thought to be impossible. However, even today women are significantly underrepresented in sports performance research. By focusing more research on the female physiology and sex differences between men and women, we can better define how women differ from men in adapting to training and potentially use this information to improve endurance-exercise performance in women. The male advantage in endurance-exercise performance has commonly been attributed to their higher VO2max, even when expressed as mL/kg/min. It is widely known that oxygen delivery is the primary limiting factor in elite athletes when it comes to improving VO2max, but little research has explored the sex differences in oxygen delivery. Thus, the purpose of this review is to highlight what is known about the sex differences in the physiological factors contributing to VO2max, more specifically oxygen delivery, and the impacts on performance.
The distributions of insect, wind and self pollination of plants in the Netherlands in relation to habitat types and 3D vegetation structure

Plants can be pollinated in many ways, with insect, wind and selfing as the most common modes. While it seems likely that the occurrence of pollination modes is correlated with environmental conditions, e.g. vegetation structure, and this remains uncertain. Here, we mapped the composition of pollination modes of different plant groups (woody species, herbs, and grasses) across (semi-)natural habitats and their distributions in relation to 3D vegetation structure in the Netherlands. We found insect pollination is the most common mode across (semi-)natural habitats for woody species and herbs. Woody species pollinated by insects showed an even higher percentage in dune, river swamp and swamp peat than in other habitat types, whereas herbs showed a higher percentage of insect pollination in dune than in other habitat types. Grasses were always pollinated by wind or wind-self in all habitats. Woody plants pollinated by wind showed a positive relationship with canopy densities in three different strata from 2 to 20 m vegetation, while insect pollination showed a positive relationship with the canopy density of 0.5 to 2 m vegetation. All grass presented negative relationships with canopy density. Herbs showed different relationships with canopy densities of different strata dependent on pollination modes. Insect-pollinated species increased with canopy densities of low strata but decreased with canopy density of high strata, whereas wind-pollinated species decreased with canopy density of both low and high strata. We conclude that habitat and vegetation structure are important factors driving the distribution of pollination modes.
Optical Genome Mapping as a Diagnostic Tool in Pediatric Acute Myeloid Leukemia

Simple Summary Treatment of pediatric acute myeloid leukemia (AML) is stratified according to multiple recurrent genetic aberrations, which require for detection of different diagnostic methods such as karyotyping and fluorescence in situ hybridization (FISH). The aim of this study was to analyze whether optical genome mapping (OGM), as a new all-in-one methodological approach, can identify all stratification-relevant genetic aberrations that were described by karyotyping. Therefore, frozen bone marrow and blood cells from 24 pediatric patients with AML, bi-lineage leukemia, and mixed-phenotype acute leukemia collected at diagnosis were analyzed by OGM. The results of OGM were compared with routine diagnostic results from karyotyping and FISH. We show that OGM has much potential to address limitations of cytogenetics and even identify new structural aberrations that can be useful for monitoring minimal residual disease (MRD) in patients without an MRD marker. Abstract Pediatric AML is characterized by numerous genetic aberrations (chromosomal translocations, deletions, insertions) impacting its classification for risk of treatment failure. Aberrations are described by classical cytogenetic procedures (karyotyping, FISH), which harbor limitations (low resolution, need for cell cultivation, cost-intensiveness, experienced staff required). Optical Genome Mapping (OGM) is an emerging chip-based DNA technique combining high resolution (~500 bp) with a relatively short turnaround time. Twenty-four pediatric patients with AML, bi-lineage leukemia, and mixed-phenotype acute leukemia were analyzed by OGM, and the results were compared with cytogenetics. Results were discrepant in 17/24 (70%) cases, including 32 previously unknown alterations called by OGM only. One newly detected deletion and two translocations were validated by primer walking, breakpoint-spanning PCR, and DNA sequencing. As an added benefit, in two cases, OGM identified a new minimal residual disease (MRD) marker. Comparing impact on risk stratification in de novo AML, 19/20 (95%) cases had concordant results while only OGM unraveled another high-risk aberration. Thus, OGM considerably expands the methodological spectrum to optimize the diagnosis of pediatric AML via the identification of new aberrations. Results will contribute to a better understanding of leukemogenesis in pediatric AML. In addition, aberrations identified by OGM may provide markers for MRD monitoring.
Graduating Nursing Students’ Empowerment and Related Factors: Comparative Study in Six European Countries

New nurses are needed in healthcare. To meet the role expectations of a registered nurse, nursing students must feel empowered at graduation. However, there are only a few studies focusing on nursing students’ empowerment. This study aims to describe and analyze graduating nursing students’ level of empowerment in six European countries and potential related factors. A comparative and cross-sectional study was performed in the Czech Republic, Finland, Italy, Portugal, Slovakia, and Spain with graduating nursing students (n = 1746) using the Essential Elements of Nurse Empowerment scale. Potentially related factors included age, gender, a previous degree in health care, work experience in health care, graduation to first-choice profession, intention to leave the nursing profession, level of study achievements, satisfaction with the current nursing programme, clinical practicums, theoretical education, and generic competence measured with the Nurse Competence Scale. The data were analysed statistically. Graduating nursing students’ self-assessed level of empowerment was moderate, with statistical differences between countries. Those with high empowerment had no intention to leave the nursing profession, had a higher level of study achievements, and a higher self-assessed generic competence level. The results suggest that empowerment needs to be enhanced during nursing education. Further research is needed to understand the development of empowerment during the early years of a nursing career.