Miracle-dz/UniFAR-FTUs huggingface dataset:
Prevalence and predictors for fertility-related distress among 1010 young adults 1.5 years following cancer diagnosis – results from the population-based Fex-Can Cohort study

Abstract Background Cancer treatment during reproductive ages may negatively impact fertility and there is a need of firm knowledge about the prevalence and predictors of fertility-related distress. The aim was to examine fertility-related distress in a population-based sample of young women and men recently treated for cancer and to identify predictors for this outcome. Material and methods This nationwide cohort study included 1010 individuals (694 women and 316 men), mean age 34.5 ± 4.9 and 32.1 ± 5.5, respectively, diagnosed with breast, cervical, ovarian, testicular cancers, brain tumors or lymphoma at ages 18–39 in Sweden. Participants completed a survey 1.5-year post-diagnosis to assess fertility-related distress (RCAC), emotional distress (HADS) and self-efficacy, as well as sociodemographic and clinical factors and fertility preservation. Logistic regression was used to examine associations between explanatory factors and high fertility-related distress (RCAC subscale mean >4). Results Many participants (69% of women and 47% of men) had previous children and about half reported a wish for future children. High fertility-related distress was more prevalent among women (54%) than men (27%), and women were more likely than men to report distress concerning all but one RCAC dimension after adjustment for sociodemographic factors. Use of fertility preservation was unevenly distributed (15% of women and 71% of men) and was not associated with decreased fertility-related distress. In multivariable logistic regression models, a wish for future children, being single, not having previous children, symptoms of anxiety and low self-efficacy regarding one’s ability to handle threats of infertility were associated with high fertility-related distress. Conclusion This nationwide study found a high prevalence of fertility-related distress in young women and men recently treated for cancer and identified sociodemographic and psychological predictors. Fertility preservation was not found to act as a buffer against fertility-related distress, indicating the continuous need to identify strategies to alleviate fertility distress following cancer.
CCAMLR’s precautionary approach to management focusing on Ross Sea toothfish fishery

Abstract Several recent papers have criticized the scientific robustness of the fisheries management system used by the Commission for the Conservation of Antarctic Marine Living Resources (CCAMLR), including that for Ross Sea toothfish. Here we present a response from the wider CCAMLR community to address concerns and to correct some apparent misconceptions about how CCAMLR acts to promote conservation whilst allowing safe exploitation in all of its fisheries. A key aspect of CCAMLR’s approach is its adaptive feedback nature; regular monitoring and analysis allows for adjustments to be made, as necessary, to provide a robust management system despite the statistical uncertainties inherent in any single assessment. Within the Ross Sea, application of CCAMLR’s precautionary approach has allowed the toothfish fishery to develop in a steady fashion with an associated accumulation of data and greater scientific understanding. Regular stock assessments of the fishery have been carried out since 2005, and the 2013 stock assessment estimated current spawning stock biomass to be at 75% of the pre-exploitation level. There will always be additional uncertainties which need to be addressed, but where information is lacking the CCAMLR approach to management ensures exploitation rates are at a level commensurate with a precautionary approach.
WÄWÄHABO QOB c A WÄ ͻ ASKEMA... : REFLECTIONS ON AN EPISODE FROM THE HISTORY OF THE ETHIOPIAN MONASTIC MOVEMENT

1 There is no need to quote all existing scholarly literature on Täklä Haymanot’s activities, hagiography and cult, or all works on the history of his monastic foundation, Däbrä Libanos of äwa. These topics have been discussed in a number of publications, ranging from brief entries in reference-books to chapters in monographs [ 239]: s. , e. g. , BHO 247–248, nos. 1128–1134; CERULLI 1943:228–232; TADDESSE TAMRAT 1972:160–169; DEB 157–158; KRZ 92–93, no. 151; KRISS — KRISS HEINRICH 1975:30–41; among the recent publications, s. , e. g. , BÖLL in: LTK IX, 1244–1245; TEDESCHI in: EnSanti II, 1132–1138; DERAT 2003, passim. On the hagiographic legend of Täklä Haymanot, s. DERAT 1998, NOSNITZYN 2003 (concerning the hagiographic reports on the Saint’s translatio), NOSNITSIN 2006, forthcoming (on the Synaxarion commemorative note about the Saint). Let us only recall that, according to the more or less commonly accepted chronology, Täklä Haymanot is thought to have lived in ca. 1214/15–1313; the Saint’s major annual feasts are celebrated on 24 Nä ase (obitus) and 12 G nbot (translatio). 2 As is commonly known, abba Iyäsus Mo a was one of the most prominent representatives of Däbrä ayq s ifanos, which, like Däbrä Libanos of äwa, is today one of the most venerated monasteries of Ethiopia. However, Iyäsus Mo a appears to have been somewhat less popular than a number of other holy monks. The rather local character of his cult becomes evident when compared to the countrywide veneration of Täklä Haymanot, Gäbrä Mänfäs Q ddus, Samu el of Wald bba, Zä-Mika el Arägawi, as well as of several other Oriental saints. Iyäsus Mo a’s commemoration is recorded in the Synaxarion, but only in a short notice (26 dar), not in a hagiobiographic account. His popularity could have been increased by hagiographies of other saints, where he is mentioned as a prominent monastic leader; yet, the considerable difference between the respective cults of Täklä Haymanot and Iyäsus Mo a is demonstrated, e. g. , by the number of manuscripts containing their hagiographies. Whereas Täklä Haymanot’s hagiographic tradition, represented by a substantial number of works, is attested by many dozens of manuscripts, the same cannot be said about the tradition of Iyäsus Mo a (s, e. g., DEB 92; TADDESSE TAMRAT 1970:88– 91; KRZ 78–79, no. 86; MARRASSINI 1986; TEDESCHI in: EnSanti II, 267–271; BAUM in: BKK XX, 804–806).
Job insecurity

This article examines the moderating effect of collective trust in management on the relation between job insecurity (both objective and subjective) and employee outcomes (work-related anxiety and organisational commitment). This is contextualized in the modern British workplace which has seen increased employment insecurity and widespread cynicism. We use matched employer-employee data extracted from the British Workplace Employment Relations Survey (WERS) 2011, which includes over 16,000 employees from more than 1,100 organizations. The multilevel analyses confirm that objective job insecurity (loss of important elements of a job such as cuts in pay, overtime, training, and working hours) are significantly correlated with high levels of work-related anxiety and lower levels of organizational commitment. These correlations are partially mediated by subjective job insecurity (perception of possible job loss). More importantly, collective trust in management (a consensus of management being reliable, honest and fair) significantly attenuates the negative impact of objective job insecurity on organizational commitment, and reduces the impact of subjective job insecurity on work-related anxiety. Theoretical and practical implications and limitations of these effects are discussed.
Large igneous province or long-lived magmatic arc along the eastern margin of Australia during the Cretaceous? Insights from the sedimentary record

U-Pb geochronology and Lu-Hf isotope analysis of detrital zircon from the mid-Cretaceous Winton and Mackunda Formations in the Eromanga Basin were employed to investigate regional provenance patterns in order to better understand the tectonic setting and paleogeography of eastern Australia during the late Mesozoic. A suite of Mesozoic-aged zircon populations recovered from these formations suggests that volcanism along the eastern margin of Australia was relatively continuous from the Triassic (252 Ma) to at least the mid-Cretaceous (ca. 92 Ma). Cretaceous-age zircon populations dominate the provenance record, and a distinct upsection younging trend in Cretaceous grain ages indicates that deposition was largely synchronous with ongoing volcanism to the east. Lu-Hf isotopic data suggest that these zircon populations were sourced from igneous rocks of a mixed juvenile and crustal source, similar to Lu-Hf isotopic systematics for eastern Australian zircons from Pennsylvanian–Permian igneous assemblages (307–252 Ma), for which an active convergent margin association is well established. An extensive Cretaceous volcanic terrain, now limited to the Whitsunday Igneous Association, was once located along the northeastern margin of Australia. Results from this study support the hypothesis that the Whitsunday igneous association was the main source of Cretaceous sediment to the Eromanga Basin, and likely for sediment transported across the continent southward and into the Ceduna Delta system offshore South Australia. The Whitsunday igneous association has been interpreted as a siliceous large igneous province associated with the onset of rifting in the region and linked to opening of the Tasman and Coral Seas. Yet, in this study, we document a relatively continuous Late Triassic to Late Cretaceous (240–92 Ma) age range for detrital zircons from the Mackunda and Winton Formations, consistent with relatively uninterrupted magmatic activity along the continental margin until ca. 92 Ma (earliest Turonian). Furthermore, zircon grains across this age spectrum exhibit dominantly positive to strongly positive eHf(t) values, between +4 and +12, consistent with values known for zircon suites from older magmatic arc rocks of eastern Australia. Although these data do not support a conclusive interpretation, they are consistent with an east Australian magmatic arc related to westward subduction of paleo-Pacific oceanic crust beneath eastern Australia enduring into the Cretaceous, as distinct from extensional siliceous large igneous province magmatism unrelated to subduction and generated by rupture of continental crust.
Spatial scaling of beta diversity supports the regional community concept for clades as different as ants, birds, diatoms, and trees

Aim Three fundamental and inter-related concepts have accrued debates: ecological communities, beta diversity (β), and spatial scale. Spatial scaling of β informs the community concept because the scale of maximal β corresponds to the most apparent size of an ecological community (without invoking external features of habitat, etc.). Here we test five alternative hypotheses about spatial scaling of β for ants, birds, diatoms, and trees across the contiguous USA, using spatial grains from 1 to 106 km2. We compare β scaling among clades and test hypotheses about repeatability where data permit for: (a) summer and winter bird β in six consecutive years; (b) trees through time (4 years, spaced 5 years apart). Finally, we compare different forms of β (i.e., observed and deviations from null models based on spatial heterogeneity and spatial homogeneity). Location The contiguous United States of America Time Period Recent but varying with clade Taxa Studied ants, birds, diatoms, and trees Methods We obtained data from publicly-available sources and assigned point locations to hexagonal grids ranging from 1 to 106 km2. At each spatial grain, we calculated mean pairwise β between each hexagon and its neighboring grids. We also compared alternative β measures and evaluated potential confounding effects of neighborhood size and species richness on results. Results Spatial scaling of β repeatedly supported the regional community concept among clades, though with different spatial scales per clade. Based on peak mean β, community size for trees (∼300 km2) < winter birds (∼500 km2) < summer birds (∼2000 km2) ≈ ants (∼2000 km2) < diatoms (∼11,000 km2). We note that community scales represent peaks on gradients rather than definitive one-size-fits-all scales. Spatial scaling of β was sensitive to seasonality (birds) and consistent among years for both birds and trees. Also, β deviation from a null model based on spatial heterogeneity adjusted observed β but was less sensitive to neighborhood size and species richness than β deviation based on spatial homogeneity. Main conclusions Results here indicate that: (a) similar patterns should occur across the tree of life; (b) local ecological and evolutionary forces scale up to form repeatable regional community patterns in ways not yet fully understood; (c) local biodiversity conservation efforts need to be coordinated at biogeographical scales to best achieve goals; and (d) a recent method to calculate β deviation from a null model based on spatial heterogeneity improves β research.
Multi-scale photocatalytic proximity labeling reveals cell surface neighbors on and between cells

The cell membrane proteome is the primary biohub for cell communication, yet we are only beginning to understand the dynamic protein neighborhoods that form on the cell surface and between cells. Proximity labeling proteomics (PLP) strategies using chemically reactive probes are powerful approaches to yield snapshots of protein neighborhoods but are currently limited to one single resolution based on the probe labeling radius. Here, we describe a multi-scale PLP method with tunable resolution using a commercially available histological dye, Eosin Y, which upon visible light illumination, activates three different photo-probes with labeling radii ranging from ∼100 to 3000 Å. We applied this platform to profile neighborhoods of the oncogenic epidermal growth factor receptor (EGFR) and orthogonally validated >20 neighbors using immuno-assays and AlphaFold-Multimer prediction that generated plausible binary interaction models. We further profiled the protein neighborhoods of cell-cell synapses induced by bi-specific T-cell engagers (BiTEs) and chimeric antigen receptor (CAR)T cells at longer length scales. This integrated multi-scale PLP platform maps local and distal protein networks on cell surfaces and between cells. We believe this information will aid in the systematic construction of the cell surface interactome and reveal new opportunities for immunotherapeutics.
Development of a genome scale metabolic model for the lager hybrid yeast S. pastorianus to understand evolution of metabolic pathways in industrial settings

In silico tools such as genome-scale metabolic models (GSMM) have shown to be powerful for metabolic engineering of microorganisms. Here, we created the iSP_1513 GSMM for the aneuploid hybrid S. pastorianus CBS1513 to allow top-down computational approaches to predict the evolution of metabolic pathways and to aid strain optimisation and media engineering in production processes. The iSP_1513 comprises 4062 reactions, 1808 alleles and 2747 metabolites, and takes into account the functional redundancy in the gene-protein-reaction rule caused by the presence of orthologous genes. Moreover, a universal algorithm to constrain GSMM reactions using transcriptome data was developed as a python library and enabled the integration of temperature as parameter. Essentiality datasets, growth data on various carbohydrates and volatile metabolites secretion were used to validate the model. Overall, the iSP_1513 GSMM represent an important step towards understanding the metabolic capabilities, evolutionary trajectories and adaptation potential of S. pastorianus in different industrial settings.
Estimating Wave Height Distributions from Wind Speed Distributions

Using long-term wind and wave data from five of the National Data Buoy Center (NDBC) buoy stations in the Pacific Ocean, this study examined the validity and accuracy of estimating the wave height distribution from the corresponding wind speed distribution. Both the log-normal and the Gamma distributions were used as the conditional probability distribution of significant wave height with known wind speed. The results show that the wave height distribution can be satisfactorily estimated from the wind speed distribution from both conditional distributions. Fitting of the wave height distribution from the log-normal distribution is slightly better than that from the Gamma distribution.
Direct Numerical Simulation of Bubbly Flows

For Direct Numerical Simulation (DNS) of bubbly flows on unstructured meshes of general topology (i.e. polyhedral meshes) we discuss the method-inherent numerical advantages of three main representatives of DNS methods based on sharp-interface modeling, namely the volume-conservative Volume-Of-Fluid (VOF) interface capturing method, the area-conservative Arbitrary Lagrangian-Eulerian (ALE) interface tracking method and the Level-Set (LS) front tracking method. Likewise, the two main representatives within the diffuse interface modeling framework, namely the two-phase Allen-Cahn and Cahn-Hilliard phase-field methods, are considered regarding their specific potential for DNS of bubbly flows. The
MAKING MEANING OUT OF MADNESS: PROCESSING THE 2016 PRESIDENTIAL ELECTION

The relations among meaning-making, well-being, and distress have been examined in narratives of personal self-discrepant experiences, but research is divided as to whether or not meaning-making is beneficial and little research has examined how individuals make meaning out of collective experiences. To better understand the implications of meaning-making for the self, the present study examined narrative differences between personal and collective discrepant experiences and the relations among meaning-making, distress, and well-being. One hundred and fifty-nine participants identifying as centrist to extremely liberal were asked to respond to two narrative prompts: a self-discrepant experience prompt and a prompt asking about reactions to the 2016 presidential election. Participants completed measures assessing distress, well-being, depressive and anxious symptoms, political activism, event centrality, and psychological growth. Narratives were coded for meaning-making, self-event connections, and redemption/contamination sequences. Hypotheses concerning the relations among meaning-making, well-being, and growth were supported in the political narrative condition. As hypothesized, meaning-making partially mediated the relation between distress and well-being and distress and psychological growth. However, the first mediation was moderated by event centrality, such that meaning-making in events highly central to the self reduced the effect of distress on well-being. Results are discussed in terms of implications for activism and agency. As this study suggests that meaning-making and positive self-event connections are beneficial for the self, future research should investigate how to inspire meaning-making around negative and discrepant events.
Average Slip Rate and Recurrence Interval of Large-Magnitude Earthquakes on the Western Segment of the Strike-Slip Kunlun Fault, Northern Tibet

Interpretations of satellite remote sensing images, field and trench excavation investigations, and radiocarbon dates constrain the Holocene slip rate and average recurrence interval of large earthquakes on the western segment of the strike- slip Kunlun fault related with the 2001 M w 7.8 Central Kunlun earthquake, northern Tibet. Streams and gullies developed on the alluvial fans having an average 14 C age of ∼7000 years are sinistrally offset by up to 115 m along the Kunlun fault. This constrains a slip rate of 16.4 mm/yr for the past ∼7000 years. Trenches and 14 C ages reveal that at least four seismic faulting events occurred in the past 6200 years and that the penultimate event prior to the 2001 M w 7.8 earthquake occurred during the past 400 years with an average left-lateral offset of 4–5 m. Coupling the slip rate of 16.4 mm/yr with the average offset of 4–5 m produced by individual large earthquakes, it is estimated that the average recurrence interval of large earthquakes is 300–400 years on the western segment of the Kunlun fault. Our results confirm that the Kunlun fault plays an important role as a major strike-slip fault in accommodating the horizontal eastward extrusion of Tibet.
Genotyping of hepatitis C virus in South Africa

The six major hepatitis C virus genotypes were investigated by using samples from 79 seropositive and PCR-positive blood donors from three different regions of South Africa as well as 9 patients with chronic renal failure, 19 with liver disease, and 23 with hemophilia. PCR products of the genome were typed by restriction fragment length polymorphic analysis by RsaI-HaeIII and MvaI-HinfI double digestion. Type 5 occurred in 40% of this population group; type 1 occurred in 33%; and types 2, 3, and 4 were found in 13.8, 7.7, and 2.3%, respectively.
Impact of Migration on Economic Development : A Study of some selected State

Mobility has been an inherent part of human existence since the days of civilization. Migration in today’s world is shaped by a number of factors related to economic, political, religious, life risk, and various ethnic and sociocultural issues. In this paper, an attempt has been made to investigate firstly, the impact of a variety of economic and noneconomic factors on net in migration and secondly, the impact of net migration on the level of economic development in fifteen major states of India. Using pooled cross section data for fifteen major states, it has been found that net migration is positively influenced by level of Per Capita Income and level of road infrastructure, and negatively influenced by unemployment rate and cost of living. The other variable, crime rate, has been found insignificant as a determinant of migration, indicating that people migrating from one state to other do not concern about risk of life, they are rather concerned about basic needs of life. Further, migrationdevelopment relationship tested in the present study indicates that level of development is positively associated with net migration. This finding defends the controversial belief that migration is beneficial for development and there is no reason to raise voice against human mobility in the context of Indian
The Seasonal Effects of ENSO on Atmospheric Conditions Associated with European Precipitation: Model Simulations of Seasonal Teleconnections

AbstractThe seasonal upper-tropospheric teleconnection between ENSO and the North Atlantic/European sector is explored through a series of model experiments. A barotropic vorticity equation model is linearized about climatological conditions for each season of the year, and divergence forcing is applied over the equatorial Pacific to mimic El Nino–related convective activity. During boreal fall, winter, and spring, this forcing similarly excites a northeastward-propagating stationary barotropic Rossby wave train that extends across the North Atlantic to the European coast. Strong anomalies develop over the British Isles in the vicinity of the North Atlantic jet exit. Solutions during boreal summer produce no clear wave train; however, evidence exists for a North Atlantic response because of both eastward- and westward-propagating signals. These direct responses over the Atlantic and Europe are qualitatively similar to observed ENSO-associated anomalies during boreal spring and fall, but differ structurall.