Miracle-dz/UniFAR-FTUs huggingface dataset:
Time-reversal symmetry breaking superconductivity in three-dimensional Dirac semimetallic silicides

Superconductors with broken time-reversal symmetry represent arguably one of the most promising venues for realizing highly sought-after topological superconductivity that is vital to fault-tolerant quantum computation. Here, by using extensive muon-spin relaxation and rotation measurements, we report that the isostructural silicide superconductors (Ta, Nb)OsSi spontaneously break time-reversal symmetry at the superconducting transition while surprisingly showing a fully-gapped superconductivity characteristic of conventional superconductors. The first-principles calculations show that (Ta, Nb)OsSi are three-dimensional Dirac semimetals protected by nonsymmorphic symmetries. Taking advantage of the exceptional low symmetry crystal structure of these materials, we have performed detailed theoretical calculations to establish that the superconducting ground state for both (Ta, Nb)OsSi is most likely a nonunitary triplet state.
Destroying superconductivity in thin films with an electric field

In this paper we use a Ginzburg-Landau approach to show that a suitably strong electric field can drive a phase transition from a superconductor to a normal metal. The transition is induced by taking into account corrections to the permittivity due to the superconductive gap and persists even when screening effects are considered. We test the model against recent experimental observations in which a strong electric field has been observed to control the supercurrent in superconducting thin films. We find excellent agreement with the experimental data and are able to explain several observed features. We additionally suggest a way to test our theoretical proposal via superconductor-superconductor electron tunneling.
Dissecting the Extended X-Ray Emission in the Merging Pair NGC 6240: Photoionization and Winds

We present a detailed spectral and imaging analysis of the central 15″ radius (∼7.5 kpc) region of the merger galaxy NGC 6240 that makes use of all the available Chandra-ACIS data (0.3–3 keV effective exposure of ∼190 ks). This region shows extended X-ray structures with lower-energy counterparts imaged in CO, [O iii], and Hα line emission. We find both photoionized phases of possible nuclear excitation and thermal shock-excited emission in the different large-scale components: the northwest “loop” detected in Hα, the region surrounding the two nuclei, the large outflow region to the northeast detected in [O iii], and the southern X-ray extensions. The latter could be the ionization cone of the northern nucleus, with the N counterpart being obscured by the galaxy disk. The radial distribution of the X-ray surface brightness suggests a confined hot interstellar medium at r < 2.5 kpc, with a free-flowing wind at larger radii; if the confinement is magnetic, we estimate B-field values of ∼100 μG, similar to those measured in the halo of M82. The thermal gas of the extended halo at kT ∼ 1 keV absorbs soft X-rays from the active galactic nucleus, but not the extreme ultraviolet radiation leading to a rapid increase in F [O III]/F X beyond ∼3 kpc. The α-element to Fe abundance ratios of the thermal components in the different regions of the extended X-ray emission are generally compatible with Type II supernova yields, confirming the importance of active star formation in NGC 6240.
Normalise for Fairness: A Simple Normalisation Technique for Fairness in Regression Machine Learning Problems

Algorithms and Machine Learning (ML) are increasingly affecting everyday life and several decision-making processes, where ML has an advantage due to scalability or superior performance. Fairness in such applications is crucial, where models should not discriminate their results based on race, gender, or other protected groups. This is especially crucial for models affecting very sensitive topics, like interview hiring or recidivism prediction. Fairness is not commonly studied for regression problems compared to binary classification problems; hence, we present a simple, yet effective method based on normalisation (FaiReg), which minimises the impact of unfairness in regression problems, especially due to labelling bias. We present a theoretical analysis of the method, in addition to an empirical comparison against two standard methods for fairness, namely data balancing and adversarial training. We also include a hybrid formulation (FaiRegH), merging the presented method with data balancing, in an attempt to face labelling and sample biases simultaneously. The experiments are conducted on the multimodal dataset First Impressions (FI) with various labels, namely personality prediction and interview screening score. The results show the superior performance of diminishing the effects of unfairness better than data balancing, also without deteriorating the performance of the original problem as much as adversarial training.
Characterizing particle-like charge-migration dynamics with high-order harmonic sideband spectroscopy

We introduce high-harmonic sideband spectroscopy (HHSS) and show that it can be a robust probe of attosecond charge migration (CM) in a halogenated carbon-chain molecule. We simulate both the CM and harmonic-generation (HHG) dynamics using ab initio time-dependent density-functional theory. We find that CM dynamics initiated along the molecular backbone induces sidebands in the HHG spectrum driven by a delayed laser pulse that is polarized perpendicular to the molecular axis. Monitoring the spectrum as either the HHG laser frequency or the relative delay is scanned allows for the extraction of detailed information about the time-domain characteristics of the CM process.
Bone marrow findings of idiopathic Multicentric Castleman disease: A histopathologic analysis and systematic literature review

Idiopathic multicentric Castleman disease (iMCD) is a polyclonal lymphoproliferative disorder characterized by constitutional symptoms, generalized lymphadenopathy, cytopenias, and multi‐organ dysfunction due to excessive cytokines, notably Interleukin‐6. Idiopathic multicentric Castleman disease is often sub‐classified into iMCD‐TAFRO, which is associated with thrombocytopenia (T), anasarca (A), fever/elevated C‐reactive protein (F), renal dysfunction (R), and organomegaly (O), and iMCD not otherwise specified (iMCD‐NOS), which is typically associated with thrombocytosis and hypergammaglobulinemia. The diagnosis of iMCD is challenging as consensus clinico‐pathological diagnostic criteria were only recently established and include several non‐specific lymph node histopathological features. Identification of further clinico‐pathological features commonly found in iMCD could contribute to more accurate and timely diagnoses. We set out to characterize bone marrow (BM) histopathological features in iMCD, assess differences between iMCD‐TAFRO and iMCD‐NOS, and determine if these findings are specific to iMCD. Examination of BM specimens from 24 iMCD patients revealed a high proportion with hypercellularity, megakaryocytic atypia, reticulin fibrosis, and plasmacytosis across patients with both iMCD‐NOS and iMCD‐TAFRO with significantly more megakaryocytic hyperplasia (p = 0.001) in the iMCD‐TAFRO cases. These findings were also consistent with BM findings from 185 published cases of iMCD‐NOS and iMCD‐TAFRO. However, these findings are relatively nonspecific as they can be seen in various other infectious, malignant, and autoimmune diseases.
A health action process approach for developing invitee endorsed interventions to increase mail‐out bowel cancer screening

Abstract Theory‐based, user‐informed interventions are needed to increase the low participation rates of population‐based faecal occult blood test (FOBT) bowel cancer screening. This study investigated the theoretical fit of the health action process approach (HAPA) for home FOBT screening and measured screening invitees' attitudes towards different intervention strategies. A cross‐sectional sample (n = 377), aged 50–74 years, participated in this study. Two scales were created for this study. The process approach to mail‐out screening (PAMS) scale measured HAPA constructs, and the user ratings of mail‐out screening interventions (UR‐MSI) scale measured attitudes towards different intervention strategies. Structural equation modelling was used to assess the fit of PAMS scale responses to the HAPA model, and descriptive statistics were calculated for UR‐MSI responses. PAMS results showed acceptable model fit, CFI = . 968, RMSEA = . 050 and explained 49.9% of the variation in FOBT screening participation. Positive ratings of interventions ranged from 20.47%, an intervention prompting planning to complete the FOBT kit, to 72.25%, an intervention promoting the positive health outcome associated with FOBT screening. Intervention strategies should be combined such that they target all factors specified within the HAPA model. User‐informed intervention design should be used to effectively facilitate FOBT uptake in the community.
Adverse effects of psychedelics: From anecdotes and misinformation to systematic science

Background: Despite an increasing body of research highlighting their efficacy to treat a broad range of medical conditions, psychedelic drugs remain a controversial issue among the public and politicians, tainted by previous stigmatisation and perceptions of risk and danger. Objective: This narrative review examines the evidence for potential harms of the classic psychedelics by separating anecdotes and misinformation from systematic research. Methods: Taking a high-level perspective, we address both psychological and psychiatric risks, such as abuse liability and potential for dependence, as well as medical harms, including toxicity and overdose. We explore the evidence base for these adverse effects to elucidate which of these harms are based largely on anecdotes versus those that stand up to current scientific scrutiny. Results: Our review shows that medical risks are often minimal, and that many – albeit not all – of the persistent negative perceptions of psychological risks are unsupported by the currently available scientific evidence, with the majority of reported adverse effects not being observed in a regulated and/or medical context. Conclusions: This highlights the importance for clinicians and therapists to keep to the highest safety and ethical standards. It is imperative not to be overzealous and to ensure balanced media reporting to avoid future controversies, so that much needed research can continue.
Impostorism and anxiety contribute to burnout among resident physicians

Abstract Purpose Physician burnout is an issue that has come to the forefront in the past decade. While many factors contribute to burnout the impact of impostorism and self-doubt has largely been ignored. We investigated the relationship of anxiety and impostorism to burnout in postgraduate medical learners. Materials and methods Postgraduate learners in four diverse training programs: Family Medicine (FM), Paediatric Medicine (PM), Anesthesiology (AN), and General Surgery (GS) were surveyed to identify the incidence of impostorism (IP), anxiety, and burnout. IP, anxiety, and burnout were evaluated using the Clance Impostor Phenomenon Scale (CIPS), Maslach Burnout Inventory-Human Services Survey (MBI-HSS), and the General Anxiety Disorder-7 (GAD-7) questionnaires, respectively. Burnout was defined as meeting burnout criteria on all three domains. Relationships between IP, anxiety, and burnout were explored. Results Two hundred and sixty-nine residents responded to the survey (response rate 18.8%). Respondents were distributed evenly between specialties (FM = 24.9%, PM = 33.1%, AN = 20.4%, GS = 21.6%). IP was identified in 62.7% of all participants. The average score on the CIPS was 66.4 (SD = 14.4), corresponding to ‘frequent feelings of impostorism. ’ Female learners were at higher risk for IP (RR = 1.27, 95% CI: 1.03–1.57). Burnout, as defined by meeting burnout criteria on all three subscales, was detected in 23.3% of respondents. Significant differences were seen in burnout between specialties (p = 0.02). GS residents were more likely to experience burnout (31.7%) than PM and AN residents (26.7 and 10.0%, respectively, p = 0.02). IP was an independent risk factor for both anxiety (RR = 3.64, 95% CI:1.96–6.76) and burnout (RR = 1.82, 95% CI: 1.07–3.08). Conclusions Impostorism is commonly experienced by resident learners independent of specialty and contributes to learner anxiety and burnout. Supervisors and Program Directors must be aware of the prevalence of IP and the impact on burnout. Initiatives to mitigate IP may improve resident learner wellness and decrease burnout in postgraduate learners.
Sex differences in the association of measures of sexual maturation to common toxicants: Lead, dichloro-diphenyl-trichloroethane (DDT), dichloro-diphenyl-dichloroethylene (DDE), and polychlorinated biphenyls (PCBs)

Abstract Many studies of human toxicant exposure examine the hypothesis that human sexual maturation can be affected through endocrine disruption. Within this body of literature there is significant variation in the findings. Variation may be related to the differential effects by toxicants between males and females as well as variation in sample size, toxicant levels, and the timing of exposure. We review sexual maturation outcomes between males and females when exposed to lead, dichlorodiphenyldichloroethylene (DDE), dichloro-diphenyl-trichloroethane (DDT), and polychlorinated biphenyls (PCBs) using a systematic process to gather peer-reviewed studies published from January 1994 through December 2019 on the NCBI website’s PubMed search engine. The review includes 34 studies, some comprised of multiple analyses, to compare effects on sexual maturation by sex. The analysis shows that both boys and girls have delayed sexual maturation in relation to lead exposure. There are differences in the direction of effects associated with DDE/DDT and PCB exposure in boys and girls. PCBs exist as congeners of many structural forms, and that variation is considered in this review. Dioxin-like and non-dioxin-like PCBs exposure directionality differed between boys and girls as well. Future investigations into the basis of sex variation in DDE/DDT and PCB relationships to sexual maturation are warranted.
Hyperexcitable and immature-like neuronal activity in the auditory cortex of adult rats lacking the language-linked CNTNAP2 gene

Abstract The contactin-associated protein-like 2 gene, CNTNAP2, is a highly penetrant risk gene thought to play a role in the genetic etiology of language-related disorders, such as autism spectrum disorder and developmental language disorder. Despite its candidacy for influencing language development, few preclinical studies have examined the role of CNTNAP2 in auditory processing. Using in vivo and in vitro electrophysiological recordings in a rat model with translational validity, we report that a loss of the Cntnap2 gene function caused immature-like cortical evoked potentials, delayed multiunit response latencies to acoustic stimuli, impaired temporal processing, and led to a pattern of hyperexcitability in both multiunit and single cell recordings in adulthood. These collective results provide direct evidence that a constitutive loss of Cntnap2 gene function in rats can cause auditory processing impairments similar to those seen in language-related human disorders, indicating that its contribution in maintaining cortical neuron excitability may underlie the cortical activity alterations observed in Cntnap2−/− rats.
Delay-Dependent Robust and Reliable Stabilization for Uncertain State-Delayed Systems with Actuator Failures

This paper focuses on the synthesis problem of robust and reliable stabilization for linear systems with norm bounded time varying parameter uncertainty in the state and delayed state matrices and also with actuator failures among a pre specified subset of actuators. LMI (linear matrix inequality) method is given for the memoryless state feedback synthesis problem to quadratically stabilize the given systems. The results depend on the size of the time delay via Lyapunov candidate with double integral. Finally, an example is given to illustrate the feasibility of the proposed method.
Changes in Emergency Department Arrival Times for Acute Myocardial Infarction During the COVID-19 Pandemic Suggest Delays in Care Seeking

Correspondence to: Alexander T. Janke, MD, Department of Emergency Medicine, 464 Congress Ave, Suite 260, New Haven, CT 06510. Email alexander.janke@yale.edu This manuscript was sent to Khurram Nasir, MD, MPH, MSc, Senior Guest Editor, for review by expert referees, editorial decision, and final disposition. For Sources of Funding and Disclosures, see page 171. © 2022 American Heart Association, Inc. RESEARCH LETTER
The plasma amino acid response to blended protein beverages: a randomised crossover trial

Abstract Soya–dairy protein blends can extend post-exercise muscle synthesis in young people more than whey protein control. Older adults differ metabolically from young people, and their ability to absorb amino acids from dietary protein is important for muscle function. The objective was to determine how protein source affects postprandial plasma amino acid response and/or metabolomic profile in older adults via a single-blind randomised crossover trial (n 16, males 50–70 years), using three nutritionally equivalent meal replacement drinks containing 30 g protein, from a 1:1 (mass ratio) soya:dairy blend, a 1:2 soya:dairy blend or whey protein. The outcome measures were plasma amino acid concentrations at 0–300 min postprandially and urine metabolomic fingerprint. Soya:dairy drinks gave similar amino acid response in plasma over time and similar urinary metabolite fingerprints. However, there were significant differences in plasma amino acid concentrations and AUC values for the soya:dairy drinks v. the whey protein drink. AUC for Leu, Trp and Lys was lower and AUC for Phe and Pro was higher for the soya:dairy drinks. Differences partly reflected the amino acid profiles of the drinks, but overall plasma amino acid response patterns were qualitatively unchanged. Plasma amino acid differences between the whey protein drink and the soya:dairy blends were reflected in urine metabolite patterns. In conclusion, postprandial plasma amino acid responses were broadly similar, irrespective of protein source (and soya:dairy ratio). There were significant differences for some plasma amino acid concentrations, reflecting different amino acid profiles of the protein source and influencing urine metabolite fingerprints.
Reliability and minimal detectable change of body-weight distribution and body sway between right and left brain-damaged patients at a chronic stage

Abstract Purpose To assess the reliability and minimal detectable change (MDC) of weight-bearing asymmetry (WBA) and body sway (BS) during “eyes open” (EO) and “eyes closed” (EC) conditions for those with right brain damage (RBD) and left brain damage (LBD) at a chronic stage. Methods Sixteen RBD and 16 LBD patients participated in two sessions within 15 days, composed of two trials of 30 s using a double force platform. Intraclass correlation coefficient (ICC2,1), the standard error of measurement (SEM), and MDC were calculated for WBA and BS (area and velocity of sway). Results Reliability of WBA was excellent (>0.75) except for EC for LBD patients (low SEM was found). The condition of EC was similar to or less reliable than that of EO. The MDC of WBA was 5.4 and 7.3% for LBD and RBD patients, respectively. Velocity of sway should be favored over the area of sway due to better reliability, with an MDC of 9 and 13 mm/s for RBD and LBD patients, respectively. Conclusions Parameters related to WBA and BS were highly reliable, without a difference between RBD and LBD patients, but less so in the condition of EC, and could be used for clinical rehabilitation and/or research. Implications for rehabilitation Weight-bearing asymmetry (WBA) and body sway (BS) are highly reliable posturography parameters. Reliability of WBA/BS is similar among right brain damaged (RBD) and left brain damaged (LBD) patients. A change of 5–7% can be interpreted as significant for WBA for chronic stroke. The minimal detectable change in measures is slightly higher for RBD patients.
Kinetics and Connectivity Properties of Parvalbumin- and Somatostatin-Positive Inhibition in Layer 2/3 Medial Entorhinal Cortex

Abstract Parvalbumin-positive (Pvalb+) and somatostatin-positive (Sst+) cells are the two largest subgroups of inhibitory interneurons. Studies in visual cortex indicate that synaptic connections between Pvalb+ cells are common while connections between Sst+ interneurons have not been observed. The inhibitory connectivity and kinetics of these two interneuron subpopulations, however, have not been characterized in medial entorhinal cortex (mEC). Using fluorescence-guided paired recordings in mouse brain slices from interneurons and excitatory cells in layer 2/3 mEC, we found that, unlike neocortical measures, Sst+ cells inhibit each other, albeit with a lower probability than Pvalb+ cells (18% vs 36% for unidirectional connections). Gap junction connections were also more frequent between Pvalb+ cells than between Sst+ cells. Pvalb+ cells inhibited each other with larger conductances, smaller decay time constants, and shorter delays. Similarly, synaptic connections between Pvalb+ and excitatory cells were more likely and expressed faster decay times and shorter delays than those between Sst+ and excitatory cells. Inhibitory cells exhibited smaller synaptic decay time constants between interneurons than on their excitatory targets. Inhibition between interneurons also depressed faster, and to a greater extent. Finally, inhibition onto layer 2 pyramidal and stellate cells originating from Pvalb+ interneurons were very similar, with no significant differences in connection likelihood, inhibitory amplitude, and decay time. A model of short-term depression fitted to the data indicates that recovery time constants for refilling the available pool are in the range of 50–150 ms and that the fraction of the available pool released on each spike is in the range 0.2–0.5.