Miracle-dz/UniFAR-FTUs huggingface dataset:
Efficient Scale-Invariant Generator with Column-Row Entangled Pixel Synthesis — Supplementary Material —

In this supplementary PDF, we first provide implementation details, including network architecture and training config in Sec. 1. Then we include extra quantitative results, including the transfer learning result on AFHQ-Dog, an extra comparison of CREPS with AnyresGAN and ScaleParty, and an additional ablation study in Sec. 2. Finally, we show additional qualitative results in Sec. 3. Besides, we include two extra image samples at high resolution, a qualitative video
BRD4 Inhibition as a Strategy to Prolong the Response to Standard of Care in Estrogen Receptor-Positive Breast Cancer

Simple Summary The combination of CDK4/6 inhibitors + fulvestrant or tamoxifen effectively prolongs survival in patients with estrogen receptor-positive (ER+) breast cancer. However, in the case of residual and metastatic disease, morbidity and mortality are virtually inevitable. Recently, the targeting of dysregulated epigenetic elements, and particularly BET family proteins, has generated considerable interest in the cancer field. The current study was designed to evaluate the capacity of BET inhibitors ARV-825 and ABBV-744 to improve the response to standard-of-care treatment in ER+ breast cancer. ARV-825 was effective when combined with tamoxifen in both p53 wild type and p53 null ER+ breast cancer cell lines while ABBV-744 showed effectiveness only in combination with fulvestrant plus palbociclib in p53 wild-type cells. Downregulation of both BRD4 and c-Myc are implicated as being required for the sensitizing effects of ARV-825 while c-Myc may not be involved in the case of ABBV-744. Abstract Breast cancer is the most commonly occurring malignancy in women and the second most common cause of cancer-related deaths. ER+ breast cancer constitutes approximately 70% of all breast cancer cases. The standard of care for ER+ breast cancer involves estrogen antagonists such as tamoxifen or fulvestrant in combination with CDK4/6 inhibitors such as palbociclib. However, these treatments are often not curative, with disease recurrence and metastasis being responsible for patient mortality. Overexpression of the epigenetic regulator, BRD4, has been shown to be a negative prognostic indicator in breast cancer, and BET family inhibitors such as ARV-825 and ABBV-744 have garnered interest for their potential to improve and prolong the response to current therapeutic strategies. The current work examined the potential of utilizing ARV-825 and ABBV-744 to increase the effectiveness of tamoxifen or fulvestrant plus palbociclib. ARV-825 was effective in both p53 wild-type (WT) breast tumor cells and in cells lacking functional p53 either alone or in combination with tamoxifen, while the effectiveness of ABBV-744 was limited to fulvestrant plus palbociclib in p53 WT cells. These differential effects may be related to the capacity to suppress c-Myc, a downstream target of BRD4.
Analysis of the spatial distribution of the serve and the type of serve-return in elite table tennis. Sex differences

Serve and return of the serve are among the most critical technical-tactical factors influencing performance in table tennis (TT). The present study aimed to analyse sex differences in the spatial distribution of serve and serve-return in elite TT players. A total of 48 elite TT players (men: n = 24; women: n = 24) participated in the investigation. A total of 24 matches were recorded and examined, analysing 1,177 plays and 5,319 strokes in the men’s competition and 950 games and 5,097 strokes in the women’s competition. Technical actions were analysed using an observation tool validated by two expert TT coach with a high level of agreement (K > 0.80). Men distributed their serves over zones 1 and 2 of the table, while women more frequently selected zone 5 (p < 0.05). In men, 30.1% of the serves were near the net, 63.6% in the middle zone of the table and 6.2% in the end zone of the table, while in women, these values were 10.9%, 67.2%, and 21.8%, respectively. As for the technique of the serve-return depending on the zone of the service, in men the action of the cut from zone 1 and 2 predominated, while in women this technique was more frequent from zone 5 (p < 0.05). On the other hand, the serve-return with the flip technique in zone 1, 3 and 4 was more frequent in men (p < 0.05). As for the return of the serve with the topspin technique, there were differences in zone 3, being more frequent in men (p < 0.05). Finally, the serve return with cut and defensive serve-return techniques in zones 3, 4, 5, and 6 were more frequent in women (p < 0.05). There are differences between sexes in service and return of serve actions during a match in elite players.
Waikiki: Historical analysis of an engineered shoreline

Short-term and long-term shoreline change at Waikiki Beach, Hawaii, is analyzed to enhance resource management. Bi-monthly beach profiles reveal short-term variations of the shoreline. Increased wave heights from south swells between May and October often correspond to beach volume increase, while short-period wind waves predominating between November and April correspond to volume losses. A total mean volume of 167,000 m 3 is estimated for Waikiki Beach, with an uncertainty of 15 to 40%. A net volume loss of approximately 5,200 m 3 is found between October 2000 and May 2002. The Royal Hawaiian littoral cell accounts for 93% of the loss. Historical aerial photographs and NOAA T-sheets establish a 76-year shoreline history (1925-2001). The shoreline has migrated a mean distance of 12 m seaward over this period, reflecting a high level of human intervention. Likewise, average beach width has increased by 32% since 1951. Four of seven littoral cells, however, are characterized by recent erosion at a mean erosion rate of 0.3 ± 0.1 m/yr. Of the remaining three littoral cells, two have experienced long-term accretion and one has exhibited stability. A relationship between beach width and corresponding sand volume change, established from beach profile data, is applied to historical shoreline changes to establish a history of sand volume fluctuations. Early volume fluctuations are traced to beach nourishment, typically with subsequent beach loss. Volume gains are documented across the entire shoreline between 1975 and 1985. Widespread chronic erosion characterizes the years after 1985. Despite past beach nourishment, a sediment budget for Waikiki reveals a sand volume deficit of at least 77,000 m 3 for the time period between 1951 and 2001, owing to permanent offshore losses.
Optimizing the experimental layout and the computational processing for lab-on-chip-based tomographic flow cytometry system

A quasi-common-path lateral-shearing holo-tomographic optical setup coupled to microfluidic channel is designed and build-up. We demonstrate that 3D refractive index profile of flowing cells can be efficiently retrieved. This setup is robust to external vibrations and is scaled down in dimension, in the perspective of employing such systems outside of optical labs. We apply a reconstruction algorithm based on high-order total-variation to cope with the reduced quality of the measurements acquired. Validation of such reconstruction approach is performed. The assessment of the robustness of the proposed solution is allowed by evaluating some biophysical parameters of biological relevance over the reconstructed tomograms.
Delphi Survey on the Current and Future Korean Guidelines for Isoniazid-Monoresistant Tuberculosis

Purpose Isoniazid-monoresistant tuberculosis (Hr-TB) has emerged as a global challenge, necessitating detailed guidelines for its diagnosis and treatment. We aim to consolidate the Korean guidelines for Hr-TB management by gathering expert opinions and reaching a consensus. Patients and Methods A conventional Delphi method involving two rounds of surveys was conducted with 96 experts selected based on their clinical and research experience and involvement in nationwide tuberculosis studies and development of the Korean guidelines on tuberculosis. The survey consisted of three sections of questionnaires on diagnosis, treatment, and general opinions on Hr-TB. Results Among the 96 experts, 72 (75%) participated in the two rounds of the survey. A majority of experts (96%) strongly agreed on the necessity of molecular drug susceptibility testing (DST) for isoniazid and rifampin resistance in all tuberculosis patients and emphasized the importance of interpreting mutation types (inhA or katG) and additional molecular DST for fluoroquinolones for confirmed isoniazid-resistant cases. Over 95.8% of experts recommended treating Hr-TB with a combination of rifampin, ethambutol, pyrazinamide, and levofloxacin for six months, without exceeding 12 months unless necessary. They also acknowledged the drawbacks of long-term pyrazinamide use due to its side effects and agreed on shortening its duration by extending the duration of the rest of the treatment with a modified combination of choice. Conclusion This Delphi survey enabled Korean tuberculosis experts to reach a consensus on diagnosing and treating Hr-TB. These findings will be valuable for developing the upcoming revised Korean guidelines for Hr-TB management.
Environmental heterogeneity as a driver of terrestrial biodiversity on a global scale

To improve the effectiveness of biodiversity conservation and risk assessments under global changes, it is necessary to understand the drivers of terrestrial biodiversity on a global scale. Environmental heterogeneity is an important umbrella term for different environmental factors that contribute to species diversity. Previous studies have shown that there are significant relationships between geodiversity and biodiversity on a global scale, and that heterogeneity in geodiversity features and environmental variables, that is indicators of environmental heterogeneity (EH), drive biodiversity at local and regional scales. However, we do not yet know how terrestrial biodiversity is maintained, how well represented are the different taxa, and where would they be more at risks considering their abundances and diversities. In this study, we quantified EH of climate, topography, and land cover. We used four theoretical indexes (i.e., Fisher’s alpha, Shannon’s H, Hurlbert’s PIE, and Good’s u) to quantify terrestrial biodiversity based on abundance and diversity. We used regression models to explore the relationships between environmental heterogeneity and terrestrial biodiversity across different organismic groups (ants, bats, birds, butterflies, frogs, ground beetles, mosquitoes, odonates, orthopterans, rodents, scarab beetles, and trees) globally. We found significant relationships between environmental heterogeneity and terrestrial biodiversity, particularly for trees across the three EH components (climate, topography, and land cover), however, the effects of environmental heterogeneity on terrestrial biodiversity may vary among different groups of organisms. Land cover EH could affect the terrestrial biodiversity for ants, bats, birds, butterflies, frogs, mosquitoes, odonates, orthopterans, rodents, and scarab beetles. Furthermore, there were significant relationships between topographic EH and the terrestrial biodiversity for bats, butterflies, ground beetles, odonates, and trees. Climatic EH had significant effects on the terrestrial biodiversity for all organism groups. Our study provides new insights into biodiversity conservation by considering the terrestrial biodiversity based on EH, an indicator of geodiversity.
Delay analysis of pulmonary tuberculosis in the eastern coastal county of China from 2010 to 2021: evidence from two surveillance systems

Background Tuberculosis (TB) remains a major public health challenge. However, indicators of delays in assessing effective TB prevention and control and its influencing factors have not been investigated in the eastern coastal county of China. Methods All notified pulmonary tuberculosis (PTB) cases in the Fenghua District, China were collected between 2010 and 2021 from the available TB information management system. Comparison of delays involving patient, health system, and total delays among local and migrant cases. Additionally, in correlation with available Basic Public Health Service Project system, we performed univariate and multivariate logistic regression analyses identified the influencing factors associated with patient and total delays in patients aged >60 years. Results In total, 3,442 PTB cases were notified, including 1,725 local and 1,717 migrant patients, with a male-to-female ratio of 2.13:1. Median patient and total delays of local TB patients were longer than those for migrant patients; the median health system delay did not show any significant difference. For patient delay among the older adult, female (cOR: 1.93, 95% CI: 1.07–3.48), educational level of elementary school and middle school (cOR: 0.23, 95% CI: 0.06–0.84) had a statistical difference from univariable analysis; however, patients without diabetes showed a higher delay for multiple-factor analysis (aOR: 2.12, 95% CI: 1.02–4.41). Furthermore, only the education level of elementary school and middle school presented a low total delay for both univariate (cOR: 0.22, 95% CI: 0.06–0.82) and multivariate analysis (aOR: 0.21, 95% CI: 0.05–0.83) in the older patients. Conclusion The delay of TB cases among migrants was lower than the local population in the Fenghua District, which may be related to the “healthy migrant effect”. It highlights that women, illiterate people, and people without diabetes are key groups for reducing delays among older adults. Health awareness should focus on these target populations, providing accessible health services, and reducing the time from symptom onset to diagnosis.
Antennal transcriptome analysis of odorant-binding proteins and characterization of GOBP2 in the variegated cutworm Peridroma saucia

Odorant-binding proteins (OBPs) are expressed at extremely high concentrations in the chemo-sensilla lymph of insects and have long been thought to be crucial for delivering the semiochemicals to the odorant receptors. They are represented by multiple classes: general odorant-binding proteins (GOBP1 and GOBP2) and pheromone-binding proteins. In the current study, we identified a total of 35 OBPs in the antennal transcriptome of Peridroma saucia, a worldwide pest that causes serious damage to various crops. A gene expression value (TPM, transcripts per million) analysis revealed that seven OBPs (PsauPBP1/2/3, PsauGOBP1/2, PsauOBP6, and PsauOBP8) were highly abundant in the antennae. Next, we focused on the expression and functional characterization of PsauGOBP2. Real-time quantitative-PCR analysis demonstrated that PsauGOBP2 was predominantly expressed in the antennae of both sexes. Fluorescence binding assays showed that the recombinant PsauGOBP2 strongly binds to the female sex pheromone components Z11-16: Ac (Ki = 4.2 μM) and Z9-14: Ac (Ki = 4.9 μM) and binds moderately (6 µM ≤ Ki ≤ 13 µM) to the host plant volatiles phenylethyl acetate, β-myrcene, and dodecanol. Further 3D structural modeling and molecular docking revealed that several crucial amino acid residues are involved in ligand binding. The results not only increase our understanding of the olfactory system of P. saucia but also provide insights into the function of PsauGOBP2 that has implications for developing sustainable approaches for P. saucia management.
A Study of Nektonic and Benthic Faunas of the Shallow Gulf of Mexico Off the State of Mississippi As Related to Some Physical, Chemical, and Geological Factors

A seasonal study of the nektonic and benthic faunas of the shallow Gulf of Mexico off Mississippi was conducted from January 1967 through May 1969. It was planned to sample monthly six fixed offshore stations at depths ranging from 5 to 50 fathoms in the open Gulf. In general this was carried out fairly well, as shown by Table 1, Water samples were taken from surface, midwater, and bottom levels each time a station was occupied, and temperatures and salinities were recorded for each of these. Samples were tested for the presence of nitrates, nitrites, ortho-phosphates and total phosphates. Secchi disc extinction points were recorded. Grab samples were taken for the determination of bottom composition. Plankton samples were taken from surface, midwater and bottom levels. Copepods, brachyuran zoea and megalops, stomatopod larvae, Lucifer faxonU Acetes a. carolinaCy Penilia avirostris^ Voliolum sp. and fish eggs and larvae were present in greatest abundance. Surface and benthic nekton samples were obtained. Dredge samples were made quarterly and twelve invertebrate species and three species of fishes were collected. Renilla miilleri was the most abundant species taken, and the fish catch consisted of Centropristes ocyurus, Citharichthys spilopterus and Etropus crosaotus. Accounts of 50 invertebrate species (24,679 specimens) and 129 fishes (93,563 specimens) taken in trawl hauls is presented. Temperature and salinity data are given for all species. Relative abundance, seasonal bathymetric distributions and movements, apparent growth patterns, catch per unit of effort and various biological data are noted for the most abundant species. Station 5 (40 fathoms) produced the largest percentage of trawl catches {22.1). Jtenilla miilleri was the most abundant invertebrate taken in trawling. The brown shrimp, Penaeus aztecus, was second in abundance (10.92%). The five most abundant species comprising 80.57% numerically of the catch were croaker, longspine porgy, butterfish, spot, and seatrout. The species comprising 91.89% of the catch by weight were the croaker, longspine porgy, spot, seatrout, lizardfish, butterfish, pinfish, bank sea bass, sea catfish and black fin sea robin. The families Sciaenidae, Sparidae and Stromateidae were represented by the greatest numbers and comprised 82.9% of the total catch. Families considered to be of commercial importance contributed 92.9% to the total fish catch. 2 GULF RESEARCH REPORTS
Arab-Australians Today: Citizenship and Belonging

Arab people first came to Australia in the late nineteenth century. Today more than half a million Australians claim some form of Arab ancestry. They are a diverse group, both socially and economically. New South Wales, for example, appointed Australia's first Lebanese Governor, while at the same time it was labelling groups of economically deprived young people as Lebanese gangs'. Victoria's Premier, Steve Bracks, comes from a Lebanese background. Melbourne has an important Arab business community, while newly arrived Arab immigrants have one of the highest rates of unemployment in the country. Arab-Australians Today raises important questions about immigration, settlement, marginalisation and participation in Western societies. It discusses the way early Arab immigrants were received in Australia and talks about contemporary issues of participation in the Australian political process. It examines the lives of diverse groups of people, ranging from entrepreneurs to Arab women activists to unemployed youth. It analyses issues ranging from the ways Arab-Australians grow to call Australia home, to the moral panic created around Arab youth and criminality. The book
Content, Composition, and Biosynthesis of Anthocyanin in Fragaria Species: A Review

Anthocyanins are responsible for fruit coloration and are beneficial to human health. The fruits of cultivated strawberry (Fragaria ×ananassa) varieties are colorful, a trait that attracts consumers. The fruits of wild Fragaria species, close relatives of the cultivated strawberry, vary in color. In this review, we describe the content and composition of anthocyanins in cultivated and wild strawberry varieties. We also explore the biosynthetic pathway of anthocyanins, including their transcriptional regulation mechanisms. Additionally, we discuss the effect of environmental factors on anthocyanin accumulation. This review will inform further studies toward developing anthocyanin-rich strawberries via environmental control and exogenous application of compounds.
Reliability and validity of the Thai version of the Calgary Depression Scale for Schizophrenia

Aim: The purpose of this study was to assess the reliability and validity of the Thai version of the Calgary Depression Scale for Schizophrenia (CDSS) for the evaluation of depression in patients with schizophrenia. Methods: Sixty patients with schizophrenia according to Diagnostic and Statistical Manual of Mental Disorders: Fourth Edition; Text Revision (DSM-IV-TR) criteria were recruited to the study. The Thai version of the CDSS, the Montgomery–Åsberg Depression Rating Scale (MADRS), the Hamilton Depression Rating Scale, 17-item version (HDRS-17), and the Positive and Negative Syndrome Scale (PANSS) were administered. A major depressive episode diagnosed by a psychiatrist according to the DSM-IV-TR was used as a gold standard. Results: The internal consistency of the Thai version of the CDSS was very good (Cronbach’s alpha = 0.869). The inter-rater reliability was found to be in substantial agreement with the intra-class correlation coefficient of 0.979. The test-retest reliability over a period of 3 days was high, with an intra-class correlation coefficient of 0.861. The Thai version of the CDSS showed significant correlations with the MADRS ( r = 0.887), the HDRS-17 ( r = 0.865), and the depression item of the Positive and Negative Syndrome Scale (PANSS-G6) ( r = 0.833). The areas under the receiver operating characteristic curve of the CDSS, MADRS, HDRS-17, and PANSS-G6 against the DSM-IV-TR criteria for major depressive episode were 0.993, 0.954, 0.966, and 0.933, respectively. The optimal cut-off score to discriminate between depressed and non-depressed patients was 6/7, with a sensitivity of 92.31% and specificity of 97.87%. Conclusion: The Thai version of the CDSS is a reliable and valid measure for the evaluation of depression in Thai patients with schizophrenia.
Resisting DNN-Based Website Fingerprinting Attacks Enhanced by Adversarial Training

Deep neural network (DNN) based website fingerprinting (WF) attacks pose a severe threat to the privacy of Tor users. To overcome this challenge, adversarial perturbation based WF defenses have been recently proposed to fool the classifiers of attackers, through purposefully perturbing the user’s traffic traces. Unfortunately, these defenses significantly deteriorate once the WF attacks are enhanced with adversarial training (AT). AT endows the WF attacks with more powerful website recognition capability, through learning the perturbed traffic traces generated by attackers. To resist the WF attacks enhanced by AT, we develop a black-box WF defense, called Acup3. First, Acup3 leverages many-to- one website imitation to make the traffic traces associated with different websites look more like each other, increasing the difficulty of website classification. Second, Acup3 generates trace-agnostic perturbations without accessing traffic traces, making it suitable for practical deployment. Third, Acup3 employs perturbation variation to diversify the traffic traces of different users visiting the same website, making the knowledge learnt from AT less helpful for WF attacks. Therefore, Acup3 is more robust against AT. Experiments demonstrate Acup3 markedly surpasses four representative WF defenses (e.g., Mockingbird and AWA) in defense capability and bandwidth overhead. Facing the state-of-the-art (SOTA) attack Var-CNN enhanced with AT, Acup3 depresses its attack success rate (ASR) from 98% to 24.29% with only 13.95% bandwidth overhead. Compared to the SOTA defense AWA, Acup3 causes a 24.5% larger decrement in ASR of WF attacks, and achieves a more than 100 times faster speed of perturbation generation.