Miracle-dz/UniFAR-FTUs huggingface dataset:
Edinburgh Research Explorer The influenza A virus NS1 protein promotes efficient nuclear export of unspliced viral M1 mRNA

24 Influenza A virus mRNAs are transcribed by the viral RNA-dependent RNA polymerase 25 in the cell nucleus before being exported to the cytoplasm for translation. Segment 7 produces 26 two major transcripts: an unspliced mRNA that encodes the M1 matrix protein and a spliced 27 transcript that encodes the M2 ion channel. Export of both mRNAs is dependent on the cellular 28 NXF1/TAP pathway but it is unclear how they are recruited to the export machinery or how the 29 intron-containing but unspliced M1 mRNA bypasses the normal quality control checkpoints. 30 Using fluorescent in situ hybridization to monitor segment 7 mRNA localisation, we found that 31 cytoplasmic accumulation of unspliced M1 mRNA was inefficient in the absence of NS1, both in 32 the context of segment 7 RNPs reconstituted by plasmid transfection and in mutant virus- 33 infected cells. This effect was independent of any major effect on steady-state levels of segment 34 7 mRNA or splicing, but corresponded to a ~ 5-fold reduction in the accumulation of M1. A 35 similar defect in intronless HA mRNA nuclear export was seen with an NS1 mutant virus. 36 Efficient export of M1 mRNA required both an intact NS1 RNA-binding domain and effector 37 domain. Furthermore, while wildtype NS1 interacted with cellular NXF1 and also increased the 38 interaction of segment 7 mRNA with NXF1, mutant NS1 polypeptides unable to promote mRNA 39 export did neither. Thus we propose that NS1 facilitates late viral gene expression by acting as 40 an adaptor between viral mRNAs and the cellular nuclear export machinery to promote their 41 nuclear export. 42
Prevalence of hypertension among school children in Kashmir, India

Background: Over the last two decades, there has been increased awareness that hypertension in children may be a part of the spectrum of essential hypertension mainly linked to obesity epidemic. An increasing number of children and adolescents are being diagnosed with hypertension. Objectives of this study was to determine the prevalence of hypertension among apparently healthy school children residing in the valley of Kashmir.Methods: It was a community based cross sectional study was done over a period of one year in School going children aged 11 to 16 years from both urban and rural areas of Kashmir valley.Results: Thus, prevalence of hypertension was 5.1% and prevalence of prehypertension was 9.3%. Out of total 1600 children 1464 (91.5%) had a normal BMI, 72 (4.5%) were overweight and 64 (4%) were obese. In the prehypertensive group 114 (77%) had normal BMI, 18 (12.16%) were overweight and 16 (10.8%) were obese. In the hypertensive group 30 (36.6%) had normal BMI, 26 (31.7%) were overweight and 26 (31.7%) were obese.Conclusions: Our study reveals that hypertension is not uncommon in Kashmiri children. With globalization bringing more lifestyle modifications, children are exposed to multiple risk factors including obesity and family history of hypertension. We need to make people aware of these facts so that blood pressure measurement could be a part of routine health care check-up in children to detect it early and do necessary interventions.
Dust in brown dwarfs and extra-solar planets - I. Chemical composition and spectral appearance of quasi-static cloud layers

Aims. Brown dwarfs are covered by dust cloud layers which cause inhomogeneous surface features and move below the observable τ = 1 level during the object’s evolution. The cloud layers have a strong influence on the structure and spectral appearance of brown dwarfs and extra-solar planets, e.g. by providing high local opacities and by removing condensable elements from the atmosphere causing a sub-solar metalicity in the atmosphere. We aim at understanding the formation of cloud layers in quasi-static substellar atmospheres that consist of dirty grains composed of numerous small islands of different solid condensates. Methods. The time-dependent description is a kinetic model describing nucleation, growth and evaporation. It is extended to treat gravitational settling and is applied to the static-stationary case of substellar model atmospheres. From the solution of the dust moments, we determine the grain size distribution function approximately which, together with the calculated material volume fractions, provides the basis for applying effective medium theory and Mie theory to calculate the opacities of the composite dust grains. Results. The cloud particles in brown dwarfs and hot giant-gas planets are found to be small in the high atmospheric layers (a ≈ 0.01 μm), and are composed of a rich mixture of all considered condensates, in particular MgSiO3[s], Mg2SiO4[s] and SiO2[s]. As the particles settle downward, they increase in size and reach several 100 μm in the deepest layers. The more volatile parts of the grains evaporate and the particles stepwise purify to form composite particles of high-temperature condensates in the deeper layers, mainly made of Fe[s] and Al2O3[s]. The gas phase abundances of the elements involved in the dust formation process vary by orders of magnitudes throughout the atmosphere. The grain size distribution is found to be relatively broad in the upper atmospheric layers but strongly peaked in the deeper layers. This reflects the cessation of the nucleation process at intermediate heights. The spectral appearance of the cloud layers in the mid IR (7–20 μm) is close to a grey body with only weak broad features of a few percent, mainly caused by MgSiO3[s], and Mg2SiO4[s]. These features are, nevertheless, a fingerprint of the dust in the higher atmospheric layers that can be probed by observations. Conclusions. Our models predict that the gas phase depletion is much weaker than phase-equilibrium calculations in the high atmospheric layers. Because of the low densities, the dust formation process is incomplete there, which results in considerable amounts of left-over elements that might produce stronger and broader neutral metallic lines.
Using PORTAL Data to Empirically Diagnose Freeway Bottlenecks Located on Oregon Highway 217

ABSTRACT This paper describes a systematic bottleneck identification and analysis for Oregon Highway 217 in the Portland, Oregon metropolitan region. Bottleneck studies can reveal key information about freeway operations and traffic flow characteristics . They also provide relevant and useful tools when teaching the fundamentals of traffic operations. This study uses 20 -second aggregated data collected from eleven mainline and eight on -ramp inductive loop detector stations that form part of the regional i ntelligent transportation systems (ITS) network. The data is archived by the Oregon DOT in the Portland Oregon Regional Transportation Archive Listing (PORTAL), a unique online database developed, maintained, and housed at Portland State University. This s tudy relies on the relationship between vehicle flows and occupancies to produce definitive proof of bottleneck activation during the morning peak period in the southbound travel lanes. Oblique plots comparing changes in flow and occupancy reveal time segm ents with stationary conditions and times at which transitions between congested and uncongested traffic states occur. An analysis of the data produces quantitative measurements of wave propagation speeds and queue discharge flows. Several days over a peri od of three months in 2006 are analyzed to confirm the presence of recurrent congestion and to demonstrate reproducibility. A comparison is made between recurrent congestion observed at the bottleneck site with non -recurrent congestion (due to an incident) observed at the same location on a different day. This research may contribute to additional analyses of this corridor including an ongoing ramp -metering study currently being conducted along the 217 corridor, and other analyses of Portland area freeways.
The Moderator Role of Managerial Overconfidence in the Relationship between R&D Volatility and Firm Value: An Application in Borsa Istanbul

Purpose: The study aims to reveal the moderating role of managerial overconfidence in the link between R&D volatility and firm value in firms operating in the Metal Goods Sector of Borsa Istanbul during the period 2010-2020. Design/Methodology: The moderating role of managerial overconfidence in the linkage between R&D volatility and firm value is investigated with panel data analysis. Findings: The short-run estimates reveal positive linkage determined between R&D volatility and firm value. We also reveal that managerial overconfidence positively moderates the link between R&D volatility and firm value. In this direction, the effect of R&D volatility on firm value is higher and positive in firms where managers have excessive self-confidence. Limitations: The fact that the sample consists of students who are only in Gaziantep and the use of three variables as a brand component are the limitations of the study. Originality/Value: The number of studies in the literature on the relevant period and sample is limited. Therefore, the study contributes to the literature and is original.
The Impact of Development Aid on Education and Health

• A submitted manuscript is the version of the article upon submission and before peer-review. There can be important differences between the submitted version and the official published version of record. People interested in the research are advised to contact the author for the final version of the publication, or visit the DOI to the publisher's website. • The final author version and the galley proof are versions of the publication after peer review. • The final published version features the final layout of the paper including the volume, issue and page numbers.
Modeling of Plagioclase Weathering Rates in the Sordo River Basin (North of Portugal)

Plagioclase weathering rates have been estimated in the Sordo river basin using spring water data. Relative to previous work, two improvements have been accomplished: the incorporation of travel time in the formula used to calculate the rates; the use of variable hydraulic conductivities and drainable porosities (one for each spring site) for the calculation of reacting surfaces, instead the use of average values assumed representative for the entire basin. As a consequence of such improvements, estimates of plagioclase weathering rates have been decreased by a factor of 8.7, from an average of WPl = 18.65 10 14 mol·m 2 ·s 1 (Pacheco and Alencoão, 2006) to an average of WPl = 2.15 10 14 mol·m 2 ·s 1 (this study). Incorporating the effect of time resulted in a decrease of the rates by a factor 3.2 while considering variable hydraulic conductivities and drainable porosities resulted in a decrease by a factor 2.6. The calculated weathering rates are in good agreement with experimentally measured weathering rates.
Research in International Business and Finance Short-term Overreaction to Specific Events: Evidence from an Emerging Market

This paper investigates the short-term overreaction to specific events and whether stock prices are predictable in the Egyptian stock exchange (EGX). We find evidence of the short-term over-reaction in the EGX. Losers (" bad news " portfolios) significantly outperform winners (" good news " portfolios) and investors can earn abnormal return by selling the winners and buying losers. Terrorist attacks have negative and significant abnormal returns for three days post event followed by price reversals on day four post event. Whereas, the tensions in the Middle East region have a negative and significant abnormal returns on event day followed by price reversals on day one post event. Moreover, the formation of a new government has no effect on the average abnormal returns post event in the EGX. The results also show that small firms tend to have greater price reversals compared to large firms. Overall, our results provide evidence of the leakage of information in the EGX.
Using risk factors and markers to predict bacterial respiratory co-1 /superinfections in COVID-19 patients: is the antibiotic steward’s 2 toolbox full or empty?

69 Background: 70 Adequate diagnosis of bacterial respiratory tract co-/superinfection (bRTI) in COVID-19 patients is 71 challenging, as there is insufficient knowledge about the role of risk factors and (para)clinical 72 parameters in the identification of bacterial co-/superinfection in the COVID-19 setting. Empirical 73 antibiotic therapy is mainly based on COVID-19 severity and expert opinion, rather than on scientific 74 evidence generated since the start of the pandemic. 75 Purpose: 76 Reporting the best available evidence regarding the predictive value of risk factors and (para)clinical 77 markers in the diagnosis of bRTI in COVID-19 patients.
Utilization of eye care services among primary school children in urban Kerala

Background: Visual impairment, a major health concern has three main reasons for high prevalence - non-availability, non-accessibility and non-affordability of eye care services. The poor utilization was highlighted as a concern because time interval between eye examinations was high enough for certain avoidable or curable ocular diseases to cause irreversible visual loss. Statistics relating to utilization of eye care services from Kerala and among the primary school children are few in literature. This study was conducted to estimate the pattern of utilization of eye care services for realizing the goal to reduce avoidable blindness by the year 2020. Objective: To assess utilization pattern of eye care services among primary school children. Methods: Cross sectional study in primary school children. Results: Only 35.15% of the students studying in the government and government aided schools had eye care services, their utilization was 94%. Utilization of the eye care service was 63% in the locality. Out of 1100 participants, 222 were not aware of the availability of ophthalmologist. In 523 students with symptoms, 196 (37%) had not consulted a doctor. The predictors for utilizing eye care services in locality were older students, children in private schools. Conclusion: Determining barriers to the use of eye care services is critical for planning strategies to prevent blindness, Health education and counselling can help overcome this problem.
An Overview On LoRaWAN Technology Simulation Tools

Low-Power Wide Area Networks (LPWAN) technologies are playing a pivotal role in the IoT applications owing to their capability to meet the keys IoT requirements, i.e., long-range, low cost, small data volumes, massive devices number, and low energy consumption. The creation of new public and private LoRaWAN networks necessitates the use of avoiding node limits and collision prevention measures. Designers of IoT systems confront difficulty in determining the scalability of a given technology, with an emphasis on unlicensed frequency bandwidth (ISM) transmission in densely populated locations. However, picking the best simulation software might be a challenge. To provide a conceptual overview of seven LoRaWAN simulation tools, this paper outlines their key characteristics and the sorts of experiments they support. LoRaWAN simulators, resource utilization, and performance evaluation are all covered in-depth in this report. Furthermore, we classify and compare the most important simulation tools for investigating and analyzing LoRa/LoRaWAN network emulators that have been developed recently. This article will be used to help other researchers decide whether LoRaWAN simulation tool is best for their specific requirements.
On the Accumulation and Seasonal Stratification Of Snow at the South Pole

Abstract The seasonal distribution of snow at the South Pole and its relationship to stratigraphy was investigated to pits dug beside a number of four-year-old accumulation stakes. Results show that conventional stratigraphic methods yield thoroughly reliable values of accumulation rates. Even hiatuses in accumulation can be identified from the intensity of sublimation of layers of depth hoar in the stratigraphic section. Such hiatuses are due almost invariably to the prolonged absence of accumulation rather than to widespread scouring of pre-existing layers of snow. The bulk of the year’s accumulation is deposited as dunes during winter. The majority of dunes are subsequently transformed into linear sastrugi by wind with the result that the amplitude of surface relief observed at the end of winter frequently exceeds the average thickness of snow accumulated annually. Such gross relief does not persist to the end of summer, however. Instead the dunes and sastrugi arc gradually worn down by a process of sublimation-deflation. It is this leveling of the surface relief in summer and the resultant redistribution of snow more uniformly over the surface that are believed to be the significant factors in the formation of the systematic stratigraphy observed in pits at the South Pole.
Simultaneous repositioning and removal of peritoneal dialysis catheters

2 Anesthesiology, Intensive Care and Analgesic Unit, Hospital of Jesi, Jesi Italy 3 Nephrology and Dialysis Unit, S. Anna Hospital, Como Italy 4 General Surgery Unit, Carlo Urbani Hospital, Jesi Italy 5 Nephrology and Dialysis Unit, San Bassiano Hospital, Bassano del Grappa Italy 6 Nephrology and Dialysis Unit, Treviglio-Caravaggio Hospital, Treviglio Italy 7 Nephrology and Dialysis Unit, San Giovanni Bosco Hospital, Turin Italy 8 Nephrology and Dialysis Unit, Maria Adelaide Hospital, Turin Italy 9 Nephrology and Dialysis Unit, Carlo Urbani Hospital, Jesi Italy 10 Nephrology and Dialysis Department, A. Manzoni Hospital, Lecco Italy 11 Nephrology and Dialysis Unit, Camposampiero Hospital, Camposampiero Italy 12 Nephrology and Dialysis Unit, Santa Chiara Hospital, Trento Italy 13 Nephrology, Dialysis and Transplantation Unit, University Hospital of Siena, Siena Italy 14 Nephrology, Dialysis and Renal Transplantation Unit, University Hospital Spedali Civili, Brescia Italy
ResearchOnline@ND ResearchOnline@ND

8 Talent identification and development programs seek to recognise and promote athletes with 9 long-term potential in a particular sport. Coaches involved in these programs are often 10 required to make inclusions or exclusion decisions based on their perceptions of an athlete’s 11 long-term potential. However, biological maturity can influence physical capabilities of 12 adolescent athletes and may bias coaches’ perceptions of long-term potential. This study 13 explored the relationship between coaches’ perceptions of long-term potential and variations 14 in athlete’s biological maturity. Talented adolescent male Australian footballers from nine 15 (n= 264) different teams were recruited to provide basic anthropometric information for 16 estimates of biological maturity. Coaches from each team were recruited to provide a rating 17 of their own player’s long-term potential. Coaches perceived late maturing athletes to have a 18 significantly lower long-term potential than their average (χ2=9.42, p<0.01) and early 19 (χ2=5.86, p=0.04) maturing counterparts. Of the late maturing athletes, 72% were predicted 20 to go no further than adolescent competition. No concurrent bias was evident between the 21 average or early maturing athletes. The findings of this study demonstrate coaches 22 perceptions of long-term potential can be biased by maturational variation in adolescent
Low power very high frequency resonant converter with high step down ratio

This paper presents the design of a resonant converter with a switching frequency in the very high frequency range (30-300MHz), a large step down ratio and low output power. This gives the designed converters specifications which are far from previous results. The class E inverter and rectifier have been selected for the prototype and the circuits are analyzed and simulated. Three different power stages are implemented based on different design parameters. The first prototype is with a switch with small capacitances, the second one is with a switch with low on resistance and the last one is with a large input inductor. The power stages are designed with the same specs and efficiencies from 60.7-82.9% are achieved.
Social Support and Quality of Life for Patients with Depressive Disorders

Background: Depression is recognized as one of the major health threats in the 21st century. It is a maladaptive psychosocial phenomenon that can affect many areas of patients’ lives and have a negative impact on their quality of life (QoL) and social support. Aim of the study: to assess social support and quality of life for patients with depressive disorders. Research design: A descriptive correlational research design was used to achieve the aim of the present study. Sample: A total convenient sample of 100 adult male and female depressed patients was included in the study sample. Setting: This study was carried out at outpatient clinic of Minia Hospital for psychiatric health and addiction. Patients who diagnosed as having organic brain diseases, mentally handicapped, substance abused were excluded from the study. Tools of data collection: The required data was collected through three tools. Socio – demographic Data Sheet, Interpersonal Support Evaluation List (ISEL) and Quality of Life Scale. Results: showed that 66% of depressed patient had low social support, while 50% of the depressed patients had low QOL level and there were statistical significance differences between education levels with QOL. Also, there were positive associations between QoL and social support & all its subscales except self esteem support. Conclusion: The current study showed that the highest percentage of the depressed patients had low social support and QOL. Recommendations: Establishing educational centers and hot lines for family awareness about the importance of social support and quality of life for depressed patients.
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Incarcerated youth have high levels of mental disorders. However, there are no up to date reviews examining the prevalence rates of a broad range of mental disorders and symptoms across youth justice populations. The current review aims to bridge this gap. We conducted a systematic search of the literature using PsycINFO, Medline, Embase and Web of Science databases. We used meta-analyses to produce pooled prevalence figures for each mental health disorder and symptoms, and meta-regression to test for the moderating effects of covariates, such as gender. Thirty studies were included involving 8,153 participants. Meta-regression analysis showed that females had higher prevalence rates for depression, separation anxiety disorder and suicide. Males had higher prevalence rates for conduct disorder and emerging antisocial personality disorder. Emerging personality disorders (borderline personality disorder: 21%; 95% CI: 13-28%; antisocial personality disorder: 62%; 95% CI: 39-82%) were relatively common in both genders. The findings of this meta-analysis show the need for robust mental health services in custody settings. Adopting a developmentally-focused approach would increase understanding of incarcerated youth’s needs and help to early detection of emerging personality symptoms. To improve young people’s mental health, we need to ensure that services do not misidentify young people’s needs due to diagnostic limitations.
Population dynamics of Johnieops vogleri (Bleeker) off Bombay waters

Age and growth, mortality and stock assessment of Johnieops vogleri (Bleeker) based on tha data collected from New Perry Wharf landing centre of Greater Bombay from 1979-80 to 1984.85, is reported bere. This species attains 143 mm, 227 mm and 277 mm at the end of first, second and third year respectively. The von Bertalanffy's growth parameters estimated were as follows : La = 3W nun, K=O.S077 (annual), t, -- 0.02032 years and W- a586 gm. In~antaneous rat= of total, natural and fishing mortalities were estimated # Z=2,22, M=l.lO and F11.12,