Miracle-dz/UniFAR-FTUs huggingface dataset:
The Gluten-Free Diet for Celiac Disease: Critical Insights to Better Understand Clinical Outcomes

The gluten-free diet (GFD) remains a complex paradigm in managing celiac disease (CeD) in children and adults, and there are many reasons why GFD adherence should be strict to improve outcomes. However, this is a challenging task for patients, since they need to have access to quality healthcare resources that facilitate optimal GFD adherence. Understanding the strengths and weaknesses of the GFD, tackling coexisting nutritional deficiencies, and dealing with complex situations, such as seronegative CeD or non-responsive CeD, all require the involvement of a multidisciplinary team. The short- and long-term follow-up of CeD patients should preferably be performed by a combined Gastroenterology and Nutrition service with well-defined quality standards and the multidisciplinary involvement of physicians, nurses, dietitians, and psychologists. Nutritional advice and counseling by an experienced dietitian can reduce the costs associated with long-term follow-up of CeD patients. Likewise, psychological interventions may be essential in specific scenarios where implementing and sustaining a lifelong GFD can cause a significant psychological burden for patients. This manuscript aims to provide guidelines to improve clinical practice in the follow-up and monitoring of CeD patients and provide information on the nutritional risks of an ill-advised GFD. Clinicians, biochemists, food technologists, dietitians, and psychologists with a global view of the disease have been involved in its writing.
Making replant decisions.

Weather and disease problems frequently contribute to cotton stand losses. When adverse conditions result in poor emergence or uneven thinning, replanting may be necessary. Decisions regarding replanting should be based on objective evaluations of the remaining stand, stand uniformity, condition of the surviving plants and the costs associated with replanting. Inadequate, skippy stands are usually the primary considerations in the replant decision. Once the decision to replant has been made, consideration must be given to fine tuning the production system to optimize productivity of late planted cotton.
Fireblight Susceptibility, Growth, and Other Characteristics in Ornamental Pears in Alabama

Pyrus calleryana and nine cultivars were evaluated for fireblight susceptibility, flowering, growth habit, fall leaf color, and fruiting in southern conditions. Disease susceptibility to fireblight (Erwinia amylovora) was monitored during the spring season. Aristocrat and Autumn Blaze were highly susceptible as indicated by the number of infected shoots per tree and shoot length dieback. Bradford was the least sensitive to fireblight. Bradford was the earliest flowering cultivar, with flowering beginning in late March to early April and Aristocrat was the last cultivar to flower, beginning 10-14 days later. Autumn Blaze developed fall leaf color by mid- October while Bradford's leaf color peaked in mid-November. Aristocrat, Autumn Blaze, Bradford, Cleveland Select, Earlyred, and Fauriei developed rounded to pyramidal canopy forms. Capital, Redspire, and Whitehouse developed upright canopy forms.
Fabrication of PEG-PLGA Microparticles with Tunable Sizes for Controlled Drug Release Application

Polymeric microparticles of polyethyleneglycol-polylactic acid-co-glycolic acid (PEG-PLGA) are widely used as drug carriers for a variety of applications due to their unique characteristics. Although existing techniques for producing polymeric drug carriers offer the possibility of achieving greater production yield across a wide range of sizes, these methods are improbable to precisely tune particle size while upholding uniformity of particle size and morphology, ensuring consistent production yield, maintaining batch-to-batch reproducibility, and improving drug loading capacity. Herein, we developed a novel scalable method for the synthesis of tunable-sized microparticles with improved monodispersity and batch-to-batch reproducibility via the coaxial flow-phase separation technique. The study evaluated the effect of various process parameters on microparticle size and polydispersity, including polymer concentration, stirring rate, surfactant concentration, and the organic/aqueous phase flow rate and volume ratio. The results demonstrated that stirring rate and polymer concentration had the most significant impact on the mean particle size and distribution, whereas surfactant concentration had the most substantial impact on the morphology of particles. In addition to synthesizing microparticles of spherical morphology yielding particle sizes in the range of 5–50 µm across different formulations, we were able to also synthesize several microparticles exhibiting different morphologies and particle concentrations as a demonstration of the tunability and scalability of this method. Notably, by adjusting key determining process parameters, it was possible to achieve microparticle sizes in a comparable range (5–7 µm) for different formulations despite varying the concentration of polymer and volume of polymer solution in the organic phase by an order of magnitude. Finally, by the incorporation of fluorescent dyes as model hydrophilic and hydrophobic drugs, we further demonstrated how polymer amount influences drug loading capacity, encapsulation efficiency, and release kinetics of these microparticles of comparable sizes. Our study provides a framework for fabricating both hydrophobic and hydrophilic drug-loaded microparticles and elucidates the interplay between fabrication parameters and the physicochemical properties of microparticles, thereby offering an itinerary for expanding the applicability of this method for producing polymeric microparticles with desirable characteristics for specific drug delivery applications.
Demystifying the Impact of Export Promotion Programme on Export Performance of SMEs: A SEM Approach

Governments often fund export promotion programmes (EPP) to aid businesses, particularly small and medium-sized enterprises (SMEs), in getting past any barriers they may face when trying to expand internationally. However, there is scant empirical evidence showing that these initiatives are successful. Drawing on the findings of a survey of SMEs in Uttar Pradesh, India, this study clarifies how EPP strengthen firms’ export competence and activities. Based on 449 responses from registered exporters and Smart PLS-SEM, results show that perceived usefulness (PU), perceived market competencies (PM), and support mechanisms (SM) favour programme adequacy (PA) and directly affect the performance of the export. Furthermore, by elaborating on how EPPs can affect a company’s export performance (EP), this research fills a void in the current literature by examining the results of EPPs in Uttar Pradesh from the vantage point of the firm as the unit of analysis.
Palaeomagnetism of the Pieniny Klippen Belt (Carpathians): evidence for low-latitude origin and palaeogeographic dispersion of the Upper Jurassic carbonates

Institute of Geophysics, P.A. S. , ul. Ks. Janusza 64, PL-01452 Warszawa, Poland; e-mail: lemar@igf.edu.pl Institute of Geological Sciences, P.A. S. , ul. Twarda 51/55, Warszawa, Poland Department of Geology and Paleontology, Faculty of Sciences, Comenius University, Mlynská Dolina – G-1, SK-84215 Bratislava, Slovakia; e-mail: aubrecht@nic.fns.uniba.sk, rehakova@fns.uniba.sk, schlogl@nic.fns.uniba.sk Department of General Geology and Environment Protection, Faculty of Geology, Geophysics and Environmental Protection, AGH University of Science and Technology, Al. Mickiewicza 30, PL-30059 Kraków, Poland; e-mail: krobicki@geol.agh. edu.pl Institute of Geology, University of Warsaw, Al. ̊wirki i Wigury 93, PL-02089 Warszawa, Poland; e-mail: Matyja@uw.edu.pl, sima@uw.edu.pl, Andrzej.Wierzbowski@uw.edu.pl
SUPPRESSOR OF MAX2 LIKE 6, 7, and 8 Interact with DDB1 BINDING WD REPEAT DOMAIN HYPERSENSITIVE TO ABA DEFICIENT 1 to Regulate the Drought Tolerance and Target SUCROSE NONFERMENTING 1 RELATED PROTEIN KINASE 2.3 to Abscisic Acid Response in Arabidopsis

SUPPRESSOR OF MAX2-LIKE 6, 7, and 8 (SMXL6,7,8) function as repressors and transcription factors of the strigolactone (SL) signaling pathway, playing an important role in the development and stress tolerance in Arabidopsis thaliana. However, the molecular mechanism by which SMXL6,7,8 negatively regulate drought tolerance and ABA response remains largely unexplored. In the present study, the interacting protein and downstream target genes of SMXL6,7,8 were investigated. Our results showed that the substrate receptor for the CUL4-based E3 ligase DDB1-BINDING WD-REPEAT DOMAIN (DWD) HYPERSENSITIVE TO ABA DEFICIENT 1 (ABA1) (DWA1) physically interacted with SMXL6,7,8. The degradation of SMXL6,7,8 proteins were partially dependent on DWA1. Disruption of SMXL6,7,8 resulted in increased drought tolerance and could restore the drought-sensitive phenotype of the dwa1 mutant. In addition, SMXL6,7,8 could directly bind to the promoter of SUCROSE NONFERMENTING 1 (SNF1)-RELATED PROTEIN KINASE 2.3 (SnRK2.3) to repress its transcription. The mutations in SnRK2.2/2.3 significantly suppressed the hypersensitivity of smxl6/7/8 to ABA-mediated inhibition of seed germination. Conclusively, SMXL6,7,8 interact with DWA1 to negatively regulate drought tolerance and target ABA-response genes. These data provide insights into drought tolerance and ABA response in Arabidopsis via the SMXL6,7,8-mediated SL signaling pathway.
Emotions, COVID-19 related thoughts and satisfaction with life during the critical period from control to relaxation

Introduction In the context of declining mortality rates and increasing infectivity, it has become unavoidable for the majority of individuals to experience a COVID-19 infection at some point. This study aimed to investigate the psychological well-being of the general population during China’s transition period from strict control measures to relaxed policies in COVID-19 prevention and control, as well as the impact of COVID-19 related thoughts on emotion and life satisfaction during widespread infections. Methods A cross-sectional study was conducted involving a sample size of 1578 participants. Participants completed self-report questionnaires assessing positive and negative emotions, thoughts about COVID-19, and satisfaction with life. Demographic characteristics such as sex, age, and education level were controlled for in the analysis. Results The findings revealed that individuals who had been infected with COVID-19 (specifically the Omicron variant BA.5.2 or BF.7) reported lower levels of positive emotions compared to those who were uninfected or had recovered from the infection. There was a significant relationship between COVID-19-related thoughts, emotions, and life satisfaction. Positive COVID-19 related thoughts were found to mediate the relationship between negative emotions and satisfaction with life. Discussion This study represents a comprehensive examination conducted in China, focusing on assessing the impact of the COVID-19 pandemic on the general population during the critical transition period from control to relaxation. Throughout this period, the number of infections experienced fluctuations, initially rising but eventually declining over a one-month span. In such a momentous historical period, maintaining a positive perspective on COVID-19 and its management becomes paramount in enhancing the emotional well-being, life satisfaction and overall well-being of individuals.
Analytical and Numerical Investigation of the Damping Behavior of a Quarter Wave Resonator Using an Incompressible Approach

The work investigates the damping behavior of a Quarter wave resonator analytically and numerically, in which an incompressible approach is used. The Quarter wave resonator is investigated based on a methodology of decomposition that has been successfully used in the previous work of the Helmholtz resonator. The analytical investigation is implemented in MATLAB. The simulation in MATLAB contains two loops: an inner loop investigating the damping behavior in the frequency domain and an outer loop taking SPL into consideration. Iterations are applied in the outer loop to adjust the amplitude of velocity in order to make sure the SPL remains constant. The investigation is utilized to reveal the effects of the different proportion of the length of the resonator to the damping behavior. Besides, the dominance of the linear and nonlinear effect is also investigated. Furthermore, the numerical investigation is implemented in an open source software OpenFOAM. The mesh is generated by simplifying the resonator to a slice of it. Proper boundary conditions are chosen to maintain the accuracy of results and to achieve the perturbation of the incident excitation. The effect of different reference length and the mesh resolution is also investigated and the reference length and mesh resolution are set up properly. Then two approaches of obtaining the impedance of the neck are implemented in MATLAB and the results are compared. Afterward, the damping effect is evaluated. Overall, the results of the analytical investigation and numerical investigation are compared and the possible inaccuracy is pointed out.
The Association of Fibulin-2 Expression with Histopathological Grade and Fibrotic Tumor Vessel in Meningioma

Background Meningiomas are the most common primary tumors of the central nervous system. About one-fifth of meningiomas tend to recur. The World Health Organization (WHO) histopathological grade was the most useful morphological predictor of recurrence. Fibrotic tumor vessels (FTV) were detected in nearly half of WHO grade I meningiomas and correlated with vascular density and increased risk of recurrence. Fibulin-2 is an extracellular matrix glycoprotein whose expression increases in traumatic central nervous system injuries and can be used as a marker to differentiate the histopathological grade of meningiomas. This study aimed to determine the association of fibulin-2 expression with histopathological grade and FTV in meningiomas. Methods This research was an observational cross-sectional study. The study sample was 36 cases of meningioma in three Anatomical Pathology laboratories in West Sumatra on period January 2019 to December 2020. Samples obtained from resected meningioma cases were then reevaluated on Hematoxylin Eosin (HE) slides to determine the histopathological grade and FTV. Van-Gieson staining was performed to confirm FTV. Fibulin-2 expression in tumor cells was analyzed using immunohistochemical staining. Bivariate statistical analysis using the Chi-Square test with p<0.05 was considered significant. Result High-risk meningiomas (WHO grade II and III) showed high fibulin-2 expression (62.5%), whereas low-risk meningiomas (WHO grade I) were more abundant with low fibulin-2 expression (75%). The presence of FTV at low fibulin-2 expression was 58.3%. Statistical analysis showed no significant association between fibulin-2 expression with histopathological grade (p=0.077) and FTV (p=1,000). Conclusion In summary, the study showed that fibulin-2 expression was not associated to histopathological grade nor to FTV in meningiomas.
Statins and risk of type 2 diabetes: mechanism and clinical implications

Statins are widely used to prevent cardiovascular disease events. Cardiovascular diseases and type 2 diabetes are tightly connected since type 2 diabetes is a major risk factor for cardiovascular diseases. Additionally, cardiovascular diseases often precede the development of type 2 diabetes. These two diseases have common genetic and environmental antecedents. Statins are effective in the lowering of cardiovascular disease events. However, they have also important side effects, including an increased risk of type 2 diabetes. The first study reporting an association of statin treatment with the risk of type 2 diabetes was the WOSCOPS trial (West of Scotland Coronary Prevention Study) in 2001. Other primary and secondary cardiovascular disease prevention studies as well as population-based studies have confirmed original findings. The purpose of our review is to examine and summarize the most important findings of these studies as well as to describe the mechanisms how statins increase the risk of type 2 diabetes.
Structural and Electromagnetic Shielding Effectiveness of Carbon-coated Cobalt Ferrite Nanoparticles Prepared via Hydrothermal Method

|The rapid advancement of communication technology has led to an increase in electromagnetic interference (EMI), or electromagnetic (EM) pollution. This is a cause for concern, as EMI can disrupt communication services, damage electronic equipment, and pose health risks. Regulatory bodies are working to develop standards for the safe use of wireless devices, but the problem of EMI is likely to continue to grow as the number of Internet of Thing (IoT) devices continues to increase. To address this issue, this study investigated the eﬀectiveness of carbon-coated cobalt ferrite nanoparticles as a potential material for electromagnetic shielding. The synthesis of cobalt ferrite (CoFe 2 O 4 ) nanoparticles was successfully achieved using the co-precipitation method. Subsequently, a carbon coating was applied to the nanoparticles through a hydrothermal process using a 200 mL autoclave made of te(cid:13)on-lined stainless steel. This process was carried out at a temperature of 180 ◦ C for a duration of 12 hours, with a heating rate of 8 ◦ C per minute. This study examined both uncoated and carbon-coated CoFe 2 O 4 nanoparticles at various ratios of glucose to CoFe 2 O 4 (1 : 1 ; 2 : 1, and 3 : 1) using techniques such as X-ray diﬀraction (XRD), (cid:12)eld emission scanning electron microscopy (FESEM), and higher resolution transmission electron microscopy (HRTEM) analysis. The XRD analysis revealed distinct and well-de(cid:12)ned peaks corresponding to CoFe 2 O 4 , indicating the successful synthesis of the nanoparticles. The crystallite size of the uncoated CoFe 2 O 4 nanoparticles was measured to be 11.47 nm, while for the carbon-coated CoFe 2 O 4 , the average crystallite size was determined to be 14.15 nm through XRD analysis
Differentiation of glioblastoma and primary central nervous system lymphomas using multiparametric diffusion and perfusion magnetic resonance imaging

The present study aimed to determine whether combining diffusion-weighted (DWI) and dynamic susceptibility contrast-enhanced perfusion-weighted (DSC-PWI) magnetic resonance imaging (MRI) could differentiate between primary central nervous system lymphoma (PCNSL) and glioblastoma (GBM). The present retrospective study evaluated 45 patients with histologically confirmed brain tumors, of which 18 had PCNSLs and 27 had GBMs. All patients underwent conventional, DWI, and DSC-PWI MRIs before the surgical removal of the lesion or stereotactic biopsy. The solid tumor component, peritumoral edema, and abnormal white matter were measured in three regions of interest to evaluate relative cerebral blood volume (rCBV), apparent diffusion coefficient (ADC) and DWI. In conventional MRI, there were significant differences in tumor numbers, tumor enhancement type, tumor necrosis, hemorrhage and open-ring sign between GBM and PCNSL. Solid tumor ADC and rCBV values (ADCt and rCBVt, respectively) and their ratios with abnormal white matter amounts were significantly higher in GBM cases than in PCNSL cases (P<0.05). The rCBV value for peritumoral edema (rCBVe) and its ratio with abnormal white matter amount (rCBVe/n) were significantly higher in GBM cases than in PCNSL cases (P<0.05). However, ADC values did not differ significantly for peritumoral edema. DWI values did not differ significantly. Combining rCBVt and rCBVe/n provided a perfect area under the receiver operating characteristic curve of 1.00, with 100% sensitivity and 100% specificity for distinguishing GBM from PCNSL. In the results of the present study, the major criterion in the decision-making process distinguishing PCNSL from GBM was the combined rCBVt and rCBVe/n parameter. A minor criterion was the ADCt value of the lesion.
Understanding the Role of Technology in Service Innovation: a Comparison of Three Theoretical Perspectives

Service innovation has been considered as a new way to gain competitive advantage and enhance firm performance in a highly competitive market. In addition, technology is believed to encourage and facilitate service innovation. Although several service innovation studies have stressed the importance of technology in service innovation, the roles of technology in service innovation are at the center of debates in service innovation literature. One major research stream in service innovation regards technology as a service innovation dimension (e.g., Gallouj and Weinstein’ and den Hertog’s service innovation frameworks), whereas another major stream considers it an operant resource (e.g., service-dominant logic, resource-advantage theory). The contradictory situation induces the necessity to better understand the role of technology in service innovation. Therefore, this study aims to identify the role of technology in service innovation, i.e., whether it is one of service innovation dimensions or of operant resources. From a resource-based approach, this study proposes a model which considers technology as an operant resource and investigates the impact of technology on firm performance through three service innovation strategies (i.e., service creation-focused, service delivery-focused, and customer interaction-focused strategies). From a dimension-based approach, we also propose two competing models that view technology as a service innovation dimension. In the competing models, technology can influence firm performance either as a mediator between operant resources and performance, or as moderator between service innovation strategies and performance. Based on empirical data from 224 service firms in Korea, we explain the role of technology in service innovation. Our findings indicate that each approach can be used to create different theoretical arguments that explain how to leverage technology in service innovation. Our findings also show the most acceptable role of technology within this study. Keyword: Service innovation, Service innovation strategy, Technology, Operant resource.
All it takes is empathy: how virtual reality perspective-taking influences intergroup attitudes and stereotypes

Research in the past decade has demonstrated the potential of virtual reality perspective-taking (VRPT) to reduce bias against salient outgroups. In the perspective-taking literature, both affective and cognitive mechanisms have been theorized and identified as plausible pathways to prejudice reduction. Few studies have systematically compared affective and cognitive mediators, especially in relation to virtual reality, a medium posited to produce visceral, affective experiences. The present study seeks to extend current research on VRPT’s mechanisms by comparing empathy (affective) and situational attributions (cognitive) as dual mediators influencing intergroup attitudes (affective) and stereotypes (cognitive). In a between-subjects experiment, 84 participants were randomly assigned to embody a VR ingroup or outgroup waiting staff at a local food establishment, interacting with an impolite ingroup customer. Results indicated that participants in the outgroup VRPT condition reported significantly more positive attitudes and stereotypes towards outgroup members than those in the ingroup VRPT condition. For both attitudes and stereotypes, empathy significantly mediated the effect of VRPT, but situational attributions did not. Findings from this research provide support for affect as a key component of virtual experiences and how they shape intergroup perceptions. Implications and directions for further research are discussed.