Miracle-dz/UniFAR-FTUs huggingface dataset:
Effects of local anesthesia combined with intravenous midazolam and sufentanil in ophthalmic plastic surgery

Objective: To investigate the effect of local anesthesia combined with intravenous midazolam and sufentanil in ophthalmic plastic surgery. Methods: 180 patients who underwent ophthalmic surgery in our hospital from January 2018 to December 2019 were enrolled. 90 cases in the control group were given local infiltration anesthesia and 90 cases in the observation group were treated by the antiemetics topenasetron hydrochloride, midazolam and sufentanil after the establishment of intravenous channels. After local infiltration anesthesia was given, the operation started. The double-frequency index (bispectral index, BIS), systolic blood pressure (SBP), diastolic blood pressure (DBP), heart rate (HR) and respiration rate (RR) were monitored at different time points. The adverse reactions and dosage of local anesthetics were observed. Results: The SBP, DBP and HR of the control group were significantly higher than those of the observation group, BIS of the observation group were significantly lower than those of the control group, and the RR of the observation group was significantly higher than that of the control group. VAS score and local anesthetic dosage were also significantly lower in the observation group than those in the control group. The number of patients with complications in the control group was significantly larger than that in the observation group. Conclusion: Local anesthesia combined with intravenous midazolam and sufentanil can lower the SBP, DBP, HR and BIS, and improve the RR. It can also lower VAS score and local anesthetic dosage with fewer complications. It is thus suitable for anesthesia in ophthalmic plastic surgery.
Effectiveness of a Group-Based Progressive Strength Training in Primary Care to Improve the Recurrence of Low Back Pain Exacerbations and Function: A Randomised Trial

Low back pain (LBP) is the leading cause of disability and one of the most common reasons for physician visits in primary care, with a 33% rate of recurrence during the first year. However, the most optimal exercise program in this context remains unknown. The objective was to evaluate the effectiveness of a group-based progressive strength training program in non-specific chronic LBP (CLBP) patients in primary care on pain recurrence and physical function. Eighty-five patients with non-specific CLBP were separated into two groups (Intervention group: completed a progressive strength training program 3 days per week for 8 weeks; Control group: received the usual care). The intervention group showed a recurrence rate of 8.3%, while the control group had a recurrence rate of 33.3% and a shorter time until the first recurrent episode. The intervention group showed increased lumbar extensor strength, left-hand handgrip strength, and reduced the number of pain sites compared with the control group. Results also showed greater odds for reducing LBP intensity and disability in the intervention group. In conclusion, a group-based progressive strength training program is a more effective and efficient alternative than Back-School programs and can easily be carried out in the primary health care context.
DEMOCRATIC AND POPULAR ALGERIAN REPUBLIC

Digital halftoning is the process of rendering continuous tone images into relatively small number of different output levels. For example a grey scale halftoning converts a continuous 8 tone image into a lower resolution (e.g., 1 bit per pixel) for printing or display purposes. This is achieved by generating a pattern of textures that, when perceived by the human viewer, has the appearance of a constant grey value. These patterns are then locally modulated to represent detail in the image. The process of halftoning and its inverse are usually computationally expensive and algorithms that speed up this process are often desired. It is the purpose of this research project to propose efficient algorithms in terms of speed while maintaining sufficient image quality for the inverse halftoning problem. To achieve these goals we propose to use an algorithm based on the Look up Table principle for both forward halftoning and the inverse problems. The main feature of algorithms proposed is that no computation is required in the fetching of the output values thus making it a fast method. In this work, an investigation to accelerate the algorithms proposed in [17a] and [17b] but with an additional emphasis on showing how the LUT method for inverse halftoning has been carried out. The algorithms proposed have been compared to two existing and similar ones and the results obtained have shown that our algorithms perform favourably in terms of speed and image quality.
Molecular identification of protein kinase C beta in Alzheimer's disease

The purpose of this study was to investigate the potential roles of protein kinase C beta (PRKCB) in the pathogenesis of Alzheimer’s disease (AD). We identified 2,254 differentially expressed genes from 19,245 background genes in AD versus control as well as PRKCB-low versus high group. Five co-expression modules were constructed by weight gene correlation network analysis. Among them, the 1,222 genes of the turquoise module had the strongest relation to AD and those with low PRKCB expression, which were enriched in apoptosis, axon guidance, gap junction, Fc gamma receptor (FcγR)-mediated phagocytosis, mitogen-activated protein kinase (MAPK) and vascular endothelial growth factor (VEGF) signaling pathways. The intersection pathways of PRKCB in AD were determined, including gap junction, FcγR-mediated phagocytosis, MAPK and VEGF signaling pathways. Based on the performance evaluation of the area under the curve of 75.3%, PRKCB could accurately predict the onset of AD. Therefore, low expressions of PRKCB was a potential causative factor of AD, which might be involved in gap junction, FcγR-mediated phagocytosis, MAPK and VEGF signaling pathways.
Consensus on the Application of Lung Ultrasound in Pneumonia and Bronchiolitis in Children

This evidence-based consensus aims to establish the role of point-of-care lung ultrasound in the management of pneumonia and bronchiolitis in paediatric patients. A panel of thirteen experts form five Polish tertiary pediatric centres was involved in the development of this document. The literature search was done in PubMed database. Statements were established based on a review of full-text articles published in English up to December 2019. The development of this consensus was conducted according to the GRADE (Grading of Recommendations, Assessment, Development and Evaluations)—adopted and Delphi method. Initially, 22 proposed statements were debated over 3 rounds of on-line discussion and anonymous voting sessions. A total of 17 statements were agreed upon, including four statements referring to general issues, nine referring to pneumonia and four to bronchiolitis. For five statements experts did not achieve an agreement. The evidence supporting each statement was evaluated to assess the strength of each statement. Overall, eight statements were rated strong, five statements moderate, and four statements weak. For each statement, experts provided their comments based on the literature review and their own experience. This consensus is the first to establish the role of lung ultrasound in the diagnosis and management of pneumonia and bronchiolitis in children as an evidence-based method of imaging.
Independent Contributions of Dorsolateral Prefrontal Structure and Function to Working Memory in Healthy Older Adults.

Age-related differences in dorsolateral prefrontal cortex (DLPFC) structure and function have each been linked to working memory. However, few studies have integrated multimodal imaging to simultaneously investigate relationships among structure, function, and cognition. We aimed to clarify how specifically DLPFC structure and function contribute to working memory in healthy older adults. In total, 138 participants aged 65-88 underwent 3 T neuroimaging and were divided into higher and lower groups based on a median split of in-scanner n-back task performance. Three a priori spherical DLPFC regions of interest (ROIs) were used to quantify blood-oxygen-level-dependent (BOLD) signal and FreeSurfer-derived surface area, cortical thickness, and white matter volume. Binary logistic regressions adjusting for age, sex, education, and scanner type revealed that greater left and right DLPFC BOLD signal predicted the probability of higher performing group membership (P values<.05). Binary logistic regressions also adjusting for total intracranial volume revealed left DLPFC surface area that significantly predicted the probability of being in the higher performing group (P = 0.017). The left DLPFC BOLD signal and surface area were not significantly associated and did not significantly interact to predict group membership (P values>.05). Importantly, this suggests BOLD signal and surface area may independently contribute to working memory performance in healthy older adults.
Analytical and Experimental Investigation of Temporal Interference for Selective Neuromuscular Activation

This article presents an analytical method that offers both spectral and spatial information to predict local electric fields capable of driving neural activities for neuromuscular activation, and the findings of an experimental investigation on a common strategy utilizing multiple high-frequency (HF) electric fields to create an interference to recruit neural firing at depth. By introducing a cut-off frequency ${f} _{\text {cut}}$ too high to recruit neural firing in a frequency-based field descriptor, the analytical method offers an effective means to position a focused temporal interference (TI) without mechanically moving the electrodes. The experiment, which was conducted on both forearms of five healthy volunteers, validates the feasibility of the method for selective neuromuscular stimulation, where three nerve/muscles that control human fingers were independently stimulated with two current channels. The numerical and experimental findings demonstrate that the frequency-based method overcomes several limitations associated with surface-based electrical stimulation.
Characterization of the Complete Mitochondrial Genomes from Two Nitidulid Pests with Phylogenetic Implications

Simple Summary Nitidulidae is the most diverse group of Cucujoidea. In this study, we sequence and analyze two mitochondrial genomes of the nitidulid species, Xenostrongylus variegatus and Epuraea sp. Both genomes are highly conserved in their size, base content, codon usage, and secondary structure of tRNAs. Phylogenetic analyses of Nitidulidae and related families in Cucujoidea are carried out based on three outgroups and fourteen ingroups. The results of the Bayesian inference and maximum likelihood methods support the monophyly of Nitidulidae and the sister-group relationship of Kateretidae + (Monotomidae + Nitidulidae). Abstract The complete mitochondrial genomes of Xenostrongylus variegatus and Epuraea sp. were sequenced and analyzed. The total genome lengths are 17,657 and 16,641 bp, with an A+T content of 77.2% and 76.4%, respectively. Each mitochondrial genome consists of 37 coding genes and a non-coding (AT-rich) region. All protein-coding genes (PCGs) start with the standard start codon, ATN, and end with complete stop codons, TAA and TAG, or an incomplete stop codon, T. All tRNAs can be folded into the typical clover-leaf secondary structure, with the exception of trnS1 in both species with a reduced dihydrouridine (DHU) arm. The AT-rich region has tandem repeats differing in both number and length. Genetic distance and Ka/Ks analyses show that nad6 has a higher variability and more rapid evolutionary rate than other PCGs. Both maximum likelihood and Bayesian inference phylogenetic analyses based on 13 PCGs and 2 ribosome DNAs (rDNAs) agree with the previous phylogenies in supporting the Nitidulidae monophyly and the sister-group relationship of Kateretidae + (Monotomidae + Nitidulidae).
Prognostic Factors Involved in the Epithelial–Mesenchymal Transition Process in Colorectal Cancer Have a Preponderant Role in Oxidative Stress: A Systematic Review and Meta-Analysis

Simple Summary Metastasis is responsible for most of the deaths related to cancer patients. One of the hypotheses that explains the initiation of metastasis is a process called epithelial-to-mesenchymal transition (EMT), in which tumor cells change shape and acquire more aggressive properties that allows them to escape from the tumor and invade other organs. This also occurs in colorectal cancer (CRC), one of the most diagnosed types of cancer worldwide. During the past years, many scientists have discovered that certain molecules or biomarkers participating in this EMT process are able to predict the severity of the cancer and this is helping clinicians to manage treatments. Nevertheless, we think that all this information needs a detailed revision because a lot of biomarkers have been described but have not been analyzed whether they interact with each other in the same mechanism or not. Herein, we performed a bibliographic revision on this topic and identified a great number of biomarkers participating in oxidative stress, a cellular phenomenon that could have a role on the patient’s prognosis because its presence or absence on the patient’s tumor or blood had an influence on survival. Our findings suggest that oxidative stress deserves further study to understand metastasis better and to predict prognosis in a more efficient way. Abstract Epithelial-to-mesenchymal transition (EMT) is one of the most accepted mechanisms leading to metastasis, which is responsible for most of the cancer-related deaths. In order to identify EMT-related biomarkers able to predict clinical outcomes in colorectal cancer (CRC), a systematic review and meta-analysis of prognostic factors associated to overall survival (OS) and progression free survival (PFS) was conducted. The systematic literature search included studies from June 2014 to June 2019 available at PubMed and Scopus databases. Meta-analysis was performed for those markers appearing in minimum three works with a total number of 8656 participants. The rest were enlisted and subjected to functional enrichment. We identified nine clinical biomarkers and 73 EMT-related molecular biomarkers associated to OS and/or PFS in CRC. The significant enrichment of biomarkers found involved in cellular oxidoreductase activity suggests that ROS generation plays an active role in the EMT process. Clinical practice needs new biomarkers with a reliable prognostic value able to predict clinical outcomes in CRC. Our integrative work supports the role of oxidative stress in tumorigenesis and EMT progress highlighting the importance of deciphering this specific mechanism to get a better understanding of metastasis.
Phytochemical and Biological Activity Studies on Nasturtium officinale (Watercress) Microshoot Cultures Grown in RITA® Temporary Immersion Systems

The main compounds in both extracts were gluconasturtiin, 4-methoxyglucobrassicin and rutoside, the amounts of which were, respectively, determined as 182.93, 58.86 and 23.24 mg/100 g dry weight (DW) in biomass extracts and 640.94, 23.47 and 7.20 mg/100 g DW in plant herb extracts. The antioxidant potential of all the studied extracts evaluated using CUPRAC (CUPric Reducing Antioxidant Activity), FRAP (Ferric Reducing Ability of Plasma), and DPPH (1,1-diphenyl-2-picrylhydrazyl) assays was comparable. The anti-inflammatory activity of the extracts was tested based on the inhibition of 15-lipoxygenase, cyclooxygenase-1, cyclooxygenase-2 (COX-2), and phospholipase A2. The results demonstrate significantly higher inhibition of COX-2 for in vitro cultured biomass compared with the herb extracts (75.4 and 41.1%, respectively). Moreover, all the studied extracts showed almost similar antibacterial and antifungal potential. Based on these findings, and due to the fact that the growth of in vitro microshoots is independent of environmental conditions and unaffected by environmental pollution, we propose that biomass that can be rapidly grown in RITA® bioreactors can serve as an alternative source of bioactive compounds with valuable biological properties.
Vitamins in Alzheimer’s Disease—Review of the Latest Reports

Alzheimer’s disease (AD) is the most common form of dementia, and the aging of the population means that the number of cases is successively increasing. The cause of the disease has not been established, but it is suggested that many factors affect it, including nutritional aspects. As part of the work, the PubMed database has been searched, beginning from 2005, for terms related to key nutritional aspects. A diet rich in antioxidant vitamins can improve the cognitive functions of patients. Thanks to an adequate intake of B vitamins, homocysteine levels are reduced, which indirectly protects against the development of the disease. A properly balanced diet, as well as the use of appropriate supplementation, can contribute to improving the clinical condition of patients with AD.
Particle Focusing under Newtonian and Viscoelastic Flow in a Straight Rhombic Microchannel

Particle behavior in viscoelastic fluids has attracted considerable attention in recent years. In viscoelastic fluids, as opposed to Newtonian fluids, particle focusing can be simply realized in a microchannel without any external forces or complex structures. In this study, a polydimethylsiloxane (PDMS) microchannel with a rhombic cross-sectional shape was fabricated to experimentally investigate the behavior of inertial and elasto-inertial particles. Particle migration and behavior in Newtonian and non-Newtonian fluids were compared with respect to the flow rate and particle size to investigate their effect on the particle focusing position and focusing width. The PDMS rhombic microchannel was fabricated using basic microelectromechanical systems (MEMS) processes. The experimental results showed that single-line particle focusing was formed along the centerline of the microchannel in the non-Newtonian fluid, unlike the double-line particle focusing in the Newtonian fluid over a wide range of flow rates. Numerical simulation using the same flow conditions as in the experiments revealed that the particles suspended in the channel tend to drift toward the center of the channel owing to the negative net force throughout the cross-sectional area. This supports the experimental observation that the viscoelastic fluid in the rhombic microchannel significantly influences particle migration toward the channel center without any external force owing to coupling between the inertia and elasticity.
Natural Health Products (NHP’s) and Natural Compounds as Therapeutic Agents for the Treatment of Cancer; Mechanisms of Anti-Cancer Activity of Natural Compounds and Overall Trends

Most cancer therapeutics, such as tubulin-targeting chemotherapy drugs, cause cytotoxic, non-selective effects. These harmful side-effects drastically reduce the cancer patient’s quality of life. Recently, researchers have focused their efforts on studying natural health products (NHP’s) which have demonstrated the ability to selectively target cancer cells in cellular and animal models. However, the major hurdle of clinical validation remains. NHP’s warrant further clinical investigation as a therapeutic option since they exhibit low toxicity, while retaining a selective effect. Additionally, they can sensitize cancerous cells to chemotherapy, which enhances the efficacy of chemotherapeutic drugs, indicating that they can be utilized as supplemental therapy. An additional area for further research is the investigation of drug–drug interactions between NHP’s and chemotherapeutics. The objectives of this review are to report the most recent results from the field of anticancer NHP research, and to highlight the most recent advancements in possible supplemental therapeutic options.
Study on Multi-GNSS Precise Point Positioning Performance with Adverse Effects of Satellite Signals on Android Smartphone

The emergence of dual frequency global navigation satellite system (GNSS) chip actively promotes the progress of precise point positioning (PPP) technology in Android smartphones. However, some characteristics of GNSS signals on current smartphones still adversely affect the positioning accuracy of multi-GNSS PPP. In order to reduce the adverse effects on positioning, this paper takes Huawei Mate30 as the experimental object and presents the analysis of multi-GNSS observations from the aspects of carrier-to-noise ratio, cycle slip, gradual accumulation of phase error, and pseudorange residual. Accordingly, we establish a multi-GNSS PPP mathematical model that is more suitable for GNSS observations from a smartphone. The stochastic model is composed of GNSS step function variances depending on carrier-to-noise ratio, and the robust Kalman filter is applied to parameter estimation. The multi-GNSS experimental results show that the proposed PPP method can significantly reduce the effect of poor satellite signal quality on positioning accuracy. Compared with the conventional PPP model, the root mean square (RMS) of GPS/BeiDou (BDS)/GLONASS static PPP horizontal and vertical errors in the initial 10 min decreased by 23.71% and 62.06%, respectively, and the horizontal positioning accuracy reached 10 cm within 100 min. Meanwhile, the kinematic PPP maximum three-dimensional positioning error of GPS/BDS/GLONASS decreased from 16.543 to 10.317 m.
Effect of Excessive Body Weight and Psoriasis in Women Undergoing ICSI Procedure and State of Health of the Newborn

Excessive body weight and some concomitant diseases, such as psoriasis, accompany women treated due to infertility by intracytoplasmic sperm injection (ICSI). This study is aimed to assess effect of obesity and psoriasis on quality of egg cells, embryos, course of pregnancy, and state of a newborn after treatment with ICSI. A total of 140 women were included into the study (110 healthy women and 30 with psoriasis). Among healthy women, BMI negatively correlated with total recovery rate, total oocyte score, blastocyst formation rate (BFR) and amount and quality of blastocysts (r < 0, p < 0.001). The relationships were similar in psoriasis, however apart from average blastocyst quality (p = 0.17) and BFR (p = 0.352). In healthy patients, BMI negatively correlated with gestational age at delivery (r = −0.444, p = 0.010) and APGAR (r = −0.481, p = 0.005). An excess of adipose tissue exerts an unfavourable effect on female reproductive functions, especially with a simultaneous burden of psoriasis. Excessive body weight is conducive to development of gestational diabetes and shortens the duration of pregnancy. The burden of psoriasis in combination with excessive body weight has an impact on the risk of occurrence of intrauterine growth restriction of foetus. Overweight and obesity negatively affect the state of a newborn, measured using APGAR scale.