Miracle-dz/UniFAR-FTUs huggingface dataset:
HDAC7: a promising target in cancer

Histones have a vital function as components of nucleosomes, which serve as the fundamental building blocks of chromatin. Histone deacetylases (HDACs), which target histones, suppress gene transcription by compacting chromatin. This implies that HDACs have a strong connection to the suppression of gene transcription. Histone deacetylase 7 (HDAC7), a member of the histone deacetylase family, may participate in multiple cellular pathophysiological processes and activate relevant signaling pathways to facilitate the progression of different tumors by exerting deacetylation. In recent years, HDAC7 has been increasingly studied in the pathogenesis of tumors. Studies that are pertinent have indicated that it has a significant impact on the growth and metastasis of tumors, the formation of the vascular microenvironment, and the emergence of resistance to drugs. Therefore, HDAC7 could potentially function as a potent predictor for tumor prognosis and a promising target for mitigating drug resistance in tumors. This review primarily concentrates on elucidating the structure and function of HDAC7, its involvement in the development of various tumors, and its interplay with relevant signaling pathways. Meanwhile, we briefly discuss the research direction and prospect of HDAC7.
PERSONALITY AND SOCIAL PSYCHOLOGY BULLETIN Zelenski, Larsen / PERSONALITY AND LIKELIHOOD JUDGMENTS Predicting the Future: How Affect-Related Personality Traits Influence Likelihood Judgments of Future Events

The authors examine the possibility that personality traits linked to positive and negative affect susceptibilities also influence performance on a mood-sensitive cognitive task: likelihood judgments of possible positive and negative future events. In Study 1, participants (n = 104) filled out personality questionnaires, rated their current mood states, and rated the likelihood that positive and negative future events would occur. Results confirmed the hypothesis that affect-related traits predict likelihood judgments. Moreover, the personality effects were not mediated by current mood states. A second study (n = 81) replicated these personality effects on judgment in the context of manipulated moods (positive, sad, fearful, and neutral). As in Study 1, personality effects on judgment were not mediated by mood states. The authors suggest that the traits of extraversion and neuroticism include stable cognitive structures that can bias judgment in affect-congruent directions.
CzeGPT-2–Training New Model for Czech Generative Text Processing Evaluated With the Summarization Task

Automatic text summarization (ATS), alongside neural machine translation or question answering, is one of the leading tasks in Natural Language Processing (NLP). In recent years, ATS has experienced significant development, especially in the English NLP world. Modern approaches are mainly based on the versatile Transformer architecture proposed by Vaswani et al. in 2017, which has revolutionized the field, and was later tuned and adjusted to various needs of different tasks. Non-mainstream languages, with Czech taken as a representative, on the other hand, are a little bit behind these efforts and tend to use lighter or heuristic methods. With the new CzeGPT-2 model and abstractive summarizer, we would like to take a step forward detailing the process of training a GPT-2 generative transformer model for a new language with a comprehensive evaluation of the task of Czech summarization and pointing out the benefits of this approach. We also present an in-depth analysis of the errors in generated summaries, allowing to locate the model’s weak spots.
Assessment of Reference Genes Stability in Cortical Bone of Obese and Diabetic Mice

Introduction Bone, a pivotal structural organ, is susceptible to disorders with profound health implications. The investigation of gene expression in bone tissue is imperative, particularly within the context of metabolic diseases such as obesity and diabetes that augment the susceptibility to bone fractures. The objective of this study is to identify a set of internal control genes for the analysis of gene expression. Methods This study employs reverse transcription-quantitative real-time polymerase chain reaction (RT-qPCR) to assess gene expression in bone tissue. We selected fourteen housekeeping genes and assessed their stability in the cortical bone of mouse models for obesity and diabetes using four well-established algorithms (GeNorm, BestKeeper, NormFinder, and the comparative Delta Ct method). Results and Conclusion We identified Rpl13a as the mostly stably expressed reference gene in cortical bone tissue from mouse models of obesity and diabetes (db/db), while Gapdh was found to be the most stable reference gene in another diabetes model, KKAy mice. Additionally, Ef1a, Ppia, Rplp0, and Rpl22 were identified as alternative genes suitable for normalizing gene expression in cortical bone from obesity and diabetes mouse models. These findings enhance RT-qPCR accuracy and reliability, offering a strategic guide to select reference gene for studying bone tissue gene expression in metabolic disorders.
Quantitative Analysis of Isometric Ankle Torque and Muscle Activity during Dorsiflexion and Plantarflexion

الخلاصة تعتبر حركات القدم والكاحل ، مثل الثني الظهري (رفع القدم لأعلى) والثني الأخمصي (توجيه القدم لأسفل) ، أساسية لمجموعة من الأنشطة اليومية مثل المشي والجري والحفاظ على التوازن. حيث تعتمد الميكانيكا الحيوية المناسبة في هذه الحركات على تنسيق عالي بين لكل عضلة حول مفصل الكاحل. Save translation في هذا البحث تم التحقق من العلاقة بين عزم دوران الكاحل متساوي القياس والنشاط العضلي لعظلة الظنبوب الأمامية وعضلة الساق البطنية أثناء الثني الظهري والثني الأخمصي. اشتملت الدراسة على ثمانية أشخاص أصحاء ، وتم استخدام قياس النشاط الكهربي للعضلة السطحي (sEMG) لتسجيل نشاط العضلات. أظهرت النتائج أن عزم الكاحل كان أعلى أثناء الانثناء الأخمصي مقارنة بالانثناء الظهري. علاوة على ذلك ، أظهر عضلة الظنبوب الأمامية نشاطًا عضليًا أكبر أثناء الانثناء الظهري ، بينما أظهر عضلة الساق البطنية نشاطًا أعلى أثناء الثني الأخمصي. تلقي هذه النتائج الضوء على الميكانيكا الحيوية للكاحل ولما لها من آثار محتملة على التدخلات السريرية واستراتيجيات إعادة تأهيل القدم. هذه الدراسة تعطي تبريرا كافية لإجراء مزيد من البحث حول أدوار عضلات الثني الأخرى في حركات الكاحل للحصول على رؤى شاملة حول تنشيط العضلات وعزم دوران الكاحل متساوي القياس.
The Influence of Good Corporate Governance, Firm Size, and Operating Capacity on Financial Distress (Study of Retail Trade Sub-Sector Companies Listed on The Indonesian Stock Exchange in 2017-2022)

Financial distress is a situation that arises when a company has an unstable financial situation. If this condition continues, it will impact the company’s bankruptcy. This research aims to determine the influence of Good Corporate Governance, Firm Size, and Operating Capacity on Financial Distress in the retail trade sub-sector listed on the Indonesia Stock Exchange in 2017-2022. The independent variables of Good Corporate Governance include the audit committee, board of commissioners, board of directors, managerial ownership, and institutional ownership. The research method uses a quantitative and associative approach. The population in this study was 27 companies with a sampling technique using purposive sampling, and 25 companies were obtained as samples, so 150 observation data were obtained. The data analysis technique in this research uses logistic regression analysis using IBM SPSS 25 software. The partial research results show that the audit committee, managerial ownership, institutional ownership, and firm size do not affect financial distress. The board of commissioners, board of directors, and operating capacity negatively affect financial distress. Simultaneously, Good Corporate Governance, Firm Size, and Operating Capacity influence financial distress. This research implies that companies must pay attention to the good corporate governance sub-variables related to the board of commissioners and board of directors because these sub-variables have been proven to influence financial distress. Apart from that, companies must also pay attention to their operating capacity because, in this research, this variable was proven to influence financial distress.
Self-management of diabetes in adolescence: experience of Portuguese young adults and their parents

Objective To identify the factors that facilitate or hinder the construction of autonomy in adolescence through the experience of young adults with type-1 diabetes and their parents. Methods This was a qualitative, descriptive, and exploratory study. Two focus group interviews were conducted: one with nine young adults who were experts in managing their illness and the other with seven parents. Thematic and categorical content analysis was used for data analysis, with particularities of a focus group interview and the use of the NVIVO 12 software. Results Two major categories and ten subcategories related to factors that facilitated (support systems, knowledge, diet, insulin pump, early responsibility for managing therapy, and characteristics of young people) and hindered (therapeutic regimen, stigma, attitude of health professionals, characteristics of young people, and knowledge) the development of autonomy in disease management emerged. Conclusion Autonomy in the management of diabetes involves several challenges for adolescents, which requires adaptation of attitudes and interventions by professionals. In addition to the traditional management of the health condition, addressing issues related to the socialization of adolescents is essential, looking for innovative strategies that promote coping and quality of life. The results of this study make it possible to reflect on the therapeutic relationship with adolescents, emphasizing the importance of individualizing care and innovative responses to their specific needs.
Prognostic Implication of Lymphovascular Invasion in Early Gastric Cancer Meeting Endoscopic Submucosal Dissection Criteria: Insights from Radical Surgery Outcomes

Simple Summary Early gastric cancer is a condition that can often be treated effectively if caught early. A less invasive treatment, known as endoscopic submucosal dissection (ESD), has become more popular for these early-stage cancers. However, deciding which patients are best suited for this treatment requires more information. This study looked into how the presence of cancer cells in the lymph or blood vessels, a condition called lymphovascular invasion (LVI), affects the chance of cancer returning or spreading in patients eligible for ESD. By reviewing the medical records of 1369 patients treated in Shanghai, we discovered that LVI greatly increases the risk of cancer spreading to the lymph nodes and negatively affects patients’ survival rates. Our findings suggest that patients with LVI may need more aggressive treatment, such as surgery, to remove the cancer completely. This information could help doctors better decide on treatment plans for patients with early gastric cancer, potentially improving their chances of a successful recovery. This research highlights the importance of considering LVI in the treatment of early gastric cancer, which could lead to changes in how these patients are cared for in the future. Abstract Background: The management of early gastric cancer (EGC) has witnessed a rise in the utilization of endoscopic submucosal dissection (ESD) as a treatment modality, although prognostic markers are needed to guide management strategies. This study investigates the prognostic implications of lymphovascular invasion (LVI) in ESD-eligible EGC patients, specifically its implications for subsequent radical surgery. Material and methods: A retrospective, multicenter study from two primary hospitals analyzed clinicopathological data from 1369 EGC patients eligible for ESD, who underwent gastrectomy at Shanghai Cancer Center and Huashan Hospital between 2009 and 2018. We evaluated the relationship between LVI and lymph node metastasis (LNM), as well as the influence of LVI on recurrence-free survival (RFS) and overall survival (OS). Results: We found a strong association between LVI and LNM (p < 0.001). Advanced machine learning approaches, including Random Forest, Gradient Boosting Machine, and eXtreme Gradient Boosting, confirmed the pivotal role of LVI in forecasting LNM from both centers. Multivariate analysis identified LVI as an independent negative prognostic factor for both RFS and OS, with hazard ratios of 4.5 (95% CI: 2.4–8.5, p < 0.001) and 4.4 (95% CI: 2.1–8.9, p < 0.001), respectively. Conclusions: LVI is crucial for risk stratification in ESD-eligible EGC patients, underscoring the necessity for radical gastrectomy. Future research should explore the potential incorporation of LVI status into existing TNM staging systems and novel therapeutic strategies.
Association between Expression of Insulin-like Growth Factor-1 (IGF-1), IGF-1 Receptor (IGF-1R), and Hypertension-Mediated Organ Damage (HMOD) Parameters in Leukocytes and Plasma of Children/Adolescents with Primary Hypertension

A decrease in IGF-1 is often linked to inflammation. Low systemic and local IGF-1 production and downregulation of IGF-1R expression may precede and predict PH development in children/adolescents. Leukocyte mRNA expression of IGF-1 and its receptor (IGF-1R) and plasma IGF-1 were measured in a group of 39 PH children/adolescents (29 boys and 10 girls) and 35 age-matched normotensive children (19 boys and 16 girls) using the RT-PCR and ELISA tests. The expression of the IGF-1R protein was assessed by flow cytometry. Plasma IGF-1 concentration was evaluated with ELISA. The expression of IGF-1 and IGF-1R and plasma concentrations of IGF-1 did not differ between groups. However, the PH children had a decreased percentage in IGF-1R-bearing lymphocytes (p = 0.02) and monocytes (p = 0.0003), as well as a low density of IGF-R in monocytes (p = 0.02). The IGF-1 expression was negatively correlated with pulse-wave velocity (PWV) (r = −0.49), systolic blood pressure (SBP) (−0.44), and carotid intima-media thickness (cIMT) (−0.43). The IGF-1R expression was negatively correlated with PWV (r = −0.42) and SBP (r = −0.41). Our results suggest that early subclinical hypertensive arterial injury is associated with lower activity of IGF-1-IGF-1R expression and loss of protective actions.
Intraoperative Angle Measurement of Anatomical Structures: A Systematic Review

Ensuring precise angle measurement during surgical correction of orientation-related deformities is crucial for optimal postoperative outcomes, yet there is a lack of an ideal commercial solution. Current measurement sensors and instrumentation have limitations that make their use context-specific, demanding a methodical evaluation of the field. A systematic review was carried out in March 2023. Studies reporting technologies and validation methods for intraoperative angular measurement of anatomical structures were analyzed. A total of 32 studies were included, 17 focused on image-based technologies (6 fluoroscopy, 4 camera-based tracking, and 7 CT-based), while 15 explored non-image-based technologies (6 manual instruments and 9 inertial sensor-based instruments). Image-based technologies offer better accuracy and 3D capabilities but pose challenges like additional equipment, increased radiation exposure, time, and cost. Non-image-based technologies are cost-effective but may be influenced by the surgeon’s perception and require careful calibration. Nevertheless, the choice of the proper technology should take into consideration the influence of the expected error in the surgery, surgery type, and radiation dose limit. This comprehensive review serves as a valuable guide for surgeons seeking precise angle measurements intraoperatively. It not only explores the performance and application of existing technologies but also aids in the future development of innovative solutions.
Detection-Free Cross-Modal Retrieval for Person Identification Using Videos and Radar Spectrograms

The utilization of multisensors data mining and processing exhibits significant promise in forthcoming applications, with cross-modal retrieval serving as a crucial element within this realm of research. Radar offers continuous surveillance capabilities over a 24-h period, whereas cameras provide visual information about the surrounding environment. This characteristic has led to the widespread utilization of the sensors across various applications. This study centers on the task of video–radar retrieval, which, to the best of our understanding, represents the inaugural investigation of this particular subject matter. The proposed model differs from previous cross-modal retrieval tasks that utilize video data. It operates in a detection-free scenario, eliminating the need to actively identify the specific region, where the human subject is located. In order to address the challenges posed by inconsistent semantic information and a large modality gap in radar spectrograms and video frames, we propose a two-step approach. First, we introduce an identity-excluded feature removal scheme to eliminate redundant information in videos. Then, we present a two-stage feature alignment strategy to align the multimodal features, enabling retrieval without being hindered by the inherent discrepancies between the irrelevant modalities. In order to assess the efficacy of our model, we have implemented a video–radar system and constructed a cross-modal dataset. Subsequently, we have conducted a comparative analysis between our model and seven state-of-the-art cross-modal algorithms. The exemplary performance exhibited by our model demonstrates the effectiveness of our approach, while the conducted ablation studies provide empirical evidence supporting the efficiency of our design choices.
Double jeopardy: global change and interspecies competition threaten Siberian cranes

Anthropogenic global change is precipitating a worldwide biodiversity crisis, with myriad species teetering on the brink of extinction. The Arctic, a fragile ecosystem already on the frontline of global change, bears witness to rapid ecological transformations catalyzed by escalating temperatures. In this context, we explore the ramifications of global change and interspecies competition on two arctic crane species: the critically endangered Siberian crane (Leucogeranus leucogeranus) and the non-threatened sandhill crane (Grus canadensis). How might global climate and landcover changes affect the range dynamics of Siberian cranes and sandhill cranes in the Arctic, potentially leading to increased competition and posing a greater threat to the critically endangered Siberian cranes? To answer these questions, we integrated ensemble species distribution models (SDMs) to predict breeding distributions, considering both abiotic and biotic factors. Our results reveal a profound divergence in how global change impacts these crane species. Siberian cranes are poised to lose a significant portion of their habitats, while sandhill cranes are projected to experience substantial range expansion. Furthermore, we identify a growing overlap in breeding areas, intensifying interspecies competition, which may imperil the Siberian crane. Notably, we found the Anzhu Islands may become a Siberian crane refuge under global change, but competition with Sandhill Cranes underscores the need for enhanced conservation management. Our study underscores the urgency of considering species responses to global changes and interspecies dynamics in risk assessments and conservation management. As anthropogenic pressures continue to mount, such considerations are crucial for the preservation of endangered species in the face of impending global challenges.
The Effect of Charcoal-Based Dentifrice and Conventional Whitening Toothpaste on the Color Stability and Surface Roughness of Composite Resin: A Systematic Review of In Vitro Studies

The objective was to systematically review studies that evaluated the effect of charcoal-based dentifrices (CbDs) and conventional whitening toothpastes (CWTs) on the color stability (CS) and/or surface roughness (SR) of composite resin (CR). The question we focused on was “Do CbD and CWT affect the CS and/or SR of CR? ” Indexed databases were searched without language and time restrictions up to and including May 2023 using different keywords. Original experimental studies were included. The risk of bias (RoB) was assessed using the Quality Assessment Tool for In Vitro Studies. Ten in vitro studies performed on CR were included. The number of CR samples assessed ranged between 18 and 200. In one study, CbDs altered the CS and SR of CR, whereas another study showed no difference in changes in the SR and CS of CR when CbDs were compared with CWTs. One study showed that compared with CWTs, CbDs caused changes in the CS of CR but changes in SR were similar between the two dentifrices. One study showed that CbDs and CWTs improved the overall color and enhanced the SR of CR. Three studies had a high RoB, five had a medium RoB, and two had a low RoB. Compared to CWTs, CbDs appeared to affect the CS of CR, but the SR of CR induced by both dentifrices remained consistent. Further well-designed and power-adjusted studies are needed.
Retrospective land use land cover change detection using geographic information system (GIS) and remote sensing techniques: The Case of Andasa Micro-Watershed, Amhara National Regional State, Ethiopia

Land use/land cover change is a general term for the modification and conversion of the earth’s surface by human and natural factors. Land cover is the physical and biological cover of the surface. Land use covers the results of human activities for the exploitation of it. The objective of this study was to detect land cover/use changes in Andasa Watershed between the years 1995 to 2015. The study has used ArcGIS10.1 and ERDAS IMAGINE 2010, land sat images of 1995 and 2015 and socio-economic data to analyze land cover and landuse changes of Andasa watershed. The study has found that due to the population increase and improper agricultural activity forest and bush lands have declined whereas farm and bare lands expanded between the study years. Forest land and shrub land jointly decreased by 14349.23 hectare which is 23.87% of the total watershed area, whereas, cultivated land and bare land jointly increased by16010.32 hectare of land which is 26.63% of the total watershed area between the study periods, respectively. The rapid expansion of croplands and bare lands were entirely attributed to the alarming rate of depletion of forests, woods and shrubs. There is an urgent need to limit the population growth rate and implementing appropriate land use policy in the Andasa watershed. Key words: Andasa watershed, land use land cover, landsat image.
Self-regulated Learning and Academic Achievement in the EFL Classroom

This study explores the role self-regulated learning (SRL) plays in academic achievement in the EFL classroom by comparing self-regulated learning strategies use and motivational beliefs among Tunisian EFL learners coming from different achievement groups. The participants (n=59) were 8th form pupils enrolled at a preparatory school in the region of Sfax. Data was collected using the Motivated Strategies for Learning Questionnaire. Data analysis included descriptive, statistical and analytical procedures. Findings revealed that there is a positive relationship between self-regulated learning and academic achievement in the EFL context. Consequently, self-regulated learning is a predictor of academic achievement. High achievers were also found to use more frequently and consistently SRL strategies. The findings of the present study are relevant to both the field of SRL and to the advancement of EFL teaching especially in the Tunisian context.