Miracle-dz/UniFAR-FTUs huggingface dataset:
Seasonal and spatial patterns in diazotroph community composition at Station ALOHA

Dinitrogen (N2) fixation is carried out by specialized microbes, called diazotrophs, and is a major source of nitrogen supporting primary production in oligotrophic oceans. One of the best-characterized diazotroph habitats is the North Pacific Subtropical Gyre (NPSG), where warm, chronically N-limited surface waters promote year-round N2 fixation. At Station ALOHA (A Long-Term Oligotrophic Habitat Assessment) in the NPSG, N2 fixation is typically ascribed to conspicuous, filamentous cyanobacterial diazotrophs (Trichodesmium and Richelia), unicellular free-living Crocosphaera, and the UCYN-A/haptophyte symbiosis, based on using microscopy and quantitative PCR (qPCR). However, the diazotroph community in this ecosystem is diverse and includes non-cyanobacterial diazotrophs (NCDs). We investigated the diversity, depth distributions, and seasonality of diazotroph communities at Stn. ALOHA using high throughput sequencing (HTS) of nifH gene fragments from samples collected throughout the euphotic zone (0-175 m) at near-monthly intervals from June 2013 to July 2016. The UCYN-A symbioses and Trichodesmium sp. consistently had the highest relative abundances and seasonal patterns that corroborated qPCR-based analyses. Other prevalent community members included a new Crocosphaera-like species, and several NCDs affiliated with γ- and δ-proteobacteria. Notably, some of the NCDs appear to be stable components of the community at Stn. ALOHA, having also been reported in prior studies. Depth and temporal patterns in microdiversity within two major diazotroph groups (Trichodesmium and UCYN-A) suggested that sub-populations are adapted to time- and depth-dependent environmental variation. A network analysis of the upper euphotic (0-75 m) HTS data identified two modules that reflect a diazotroph community structure with seasonal turnover between UCYN-A/Gamma A, and Trichodesmium/Crocosphaera. It also reveals the seasonality of several important cyanobacteria and NCDs about which little is known, including a putative δ-proteobacterial phylotype originally discovered at Stn. ALOHA. Collectively, these results underscore the importance of coupling nifH gene HTS with other molecular techniques to obtain a comprehensive view of diazotroph community composition in the marine environment and reveal several understudied diazotroph groups that may contribute to N2 fixation in the NPSG.
HBV reactivation and its effect on survival in HBV-related hepatocarcinoma patients undergoing transarterial chemoembolization combined with tyrosine kinase inhibitors plus immune checkpoint inhibitors

Objective This study aimed to access hepatitis B virus (HBV) reactivation and its effect on survival in HBV-related hepatocarcinoma (HCC) patients who underwent transarterial chemoembolization (TACE) combined with tyrosine kinase inhibitors (TKIs) plus immune checkpoint inhibitors (ICIs). Methods In this single-center retrospective study, we enrolled 119 HBV-related unresectable advanced HCC patients receiving TACE combined with TKIs plus ICIs. Risk factors for HBV reactivation were analyzed by logistic regression. Kaplan-Meier method was applied to draw the survival curve, and log-rank test was used to compare survival between patients with and without HBV reactivation. Results A total of 12 patients (10.1%) encountered HBV reactivation in our study, of which only 4 patients received antiviral prophylaxis. The incidence of HBV reactivation was 1.8% (1/57) in patients with detectable baseline HBV DNA and 4.2% (4/95) in patients with antiviral prophylaxis respectively. Lack of prophylactic antiviral treatment (OR=0.047, 95%CI 0.008-0.273, P=0.001) and undetectable HBV DNA (OR=0.073, 95%CI 0.007-0.727, P=0.026) were independent risk factors for HBV reactivation. The median survival time (MST) for all patients was 22.4 months. No survival difference was observed in patients with or without HBV reactivation. (MST: undefined vs 22.4 months, log-rank test: P=0.614). Conclusion HBV reactivation could occur in HBV-related HCC patients who treated with TACE in combination with TKIs plus ICIs. Before and during the combination treatment, it is necessary to routinely monitor HBV DNA and to take effective prophylactic antiviral therapy.
RIPK1 and RIPK3 are positive prognosticators for cervical cancer patients and C2 ceramide can inhibit tumor cell proliferation in vitro

Introduction The enzymes Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) und 3 (RIPK3) as well as the protein Mixed lineage kinase domain like pseudokinase (pMLKL) play a role in the signaling cascade of necroptosis. This is a form of programmed cell death which is caspase-independent. High-risk human papilloma virus infection can inhibit necroptosis. Thereby, a persistent infection and consequently the development of cervical cancer can be triggered. Aim of this study was the analysis of the expression of RIPK1, RIPK3 and pMLKL in cervical cancer tissue and the evaluation of its prognostic value on overall survival, progression-free survival and additional clinical parameters. Methods The expression of RIPK1, RIPK3, and pMLKL in cervical cancer tissue microarrays of n = 250 patients was analyzed immunohistochemically. Further, the effect of C2 ceramide on several cervical cancer cell lines (CaSki, HeLa, SiHa) was examined. C2 ceramide is a biologically active short-chain ceramide that induces necroptosis in human luteal granulosa cells. Results Significantly longer overall survival and progression-free survival rates could be detected in cervical cancer patients expressing nuclear RIPK1 or RIPK3 alone or simultaneously (RIPK1 and RIPK3). Cell viability and proliferation was reduced through C2 ceramide stimulation of cervical cancer cells. Simultaneous stimulation of C2 ceramide and the pan-caspase inhibitor Z-VAD-fmk, or the RIPK1-inhibitor necrostatin-1, partly reversed the negative effect of C2 ceramide on cell viability. This observation could imply that caspase-dependent and -independent forms of cell death, including necroptosis, can occur. AnnexinV-FITC apoptosis staining induced a significant increase in apoptotic cells in CaSki and SiHa cells. The stimulation of CaSki cells with C2 ceramide led to a significant percentual increase in necrotic/intermediate (dying) cells after stimulation with C2 ceramide. In addition, after stimulation with C2 ceramide, CaSki and HeLa cells live cell imaging showed morphological changes which are common for necroptosis. Discussion In conclusion, RIPK1 and RIPK3 are independent positive predictors for overall survival and progression-free survival in cervical cancer patients. C2 ceramide can reduce cell viability and proliferation in cervical cancer cells by inducing most likely both apoptosis and necroptosis.
Short-term auditory memory interference: The Deutsch demonstration revisited

The interference effect of nonspeech and speech in short-term auditory memory was investigated with an experiment paradigm proposed by Deutsch [Science, 168, 1604–1605 (1970)], in which test tones, separated by a 5-s retention interval, were interpolated with six other sounds. In Experiment 1, the test tones were pure tones. The interpolated sounds were pure tones and naturally spoken digits by a female and a male. Nine participants were tested for (1) pure-test-tone pitch recognition, (2) serial recall of the interpolated spoken digits, and (3) both tasks (1) and (2). Pitch recognition errors were significantly increased in task (3) compared to task (1), and the digit recall errors were also significantly increased in task (3). In Experiment 2, the test tones were eight-component harmonic complex tones. The interpolated sounds were eight-component harmonic complex tones, and naturally spoken digits by a male. Twelve participants were tested for the corresponding task conditions as in Experiment 1. Significant increases in the errors of pitch recognition and of digit recall were observed when both tasks were required. These results suggest that speech can interfere with tone pitch in short-term auditory memory, and that pitch salience plays a crucial role in the interference.
See you somewhere in the ocean: few-shot domain adaptive underwater object detection

The current data-driven underwater object detection methods have significantly progressed. However, there are millions of marine creatures in the oceans, and collecting a corresponding database for each species for similar tasks (such as object detection)is expensive. Besides, marine environments are more complex than in-air cases. Water quality, illuminations, and seafloor topography may lead to domain shifting with visual instability features of underwater objects. To tackle these problems, we propose a few-shot adaptive object detection framework with a novel two-stage training approach and a lightweight feature correction module to accommodate both image-level and instance-level domain shifting on multiple datasets. Our method can be trained in a source domain and quickly adapt to an unfamiliar target domain with only a few labeled samples. Extensive experimental results have demonstrated the knowledge transfer capability of the proposed method in detecting two similar marine species. The code will be available at: https://github.com/roadhan/FSCW
Fitting Daily Precipitation Amounts Using the SB Distribution

Abstract The log-normal, gamma, Weibull, S8 and beta distributions were fit to daily precipitation amounts foreach calendar month for a 38-year period. Data are from the high precipitation zone of the southernAppalachian Mountains. The S8 distribution, a generalization of the log-normal, consistently fit the databest. There was no striking evidence that precipitation distribution differed by month. The SB distributionalso was best when fit to all precipitation days without regard to date. The gamma distribution fit rainfallamounts accumulated for two and three consecutive wet days best. Higher order Markov chains, up through the fifth order, described our data better than lower orderchains. Thus, the probability of precipitation on any day depends on what happened on at least the fiveprevious days. The SB distribution of precipitation amounts on all dates preceded by dry days is differentfrom the distribution of amounts on all dates preceded by precipitation days. The SBB distribution, a simplebivariate e.
Markov decision process algorithms for wealth allocation problems with defaultable bonds

Abstract In this paper we are concerned with analysing optimal wealth allocation techniques within a defaultable financial market similar to Bielecki and Jang (2007). We study a portfolio optimization problem combining a continuous-time jump market and a defaultable security; and present numerical solutions through the conversion into a Markov decision process and characterization of its value function as a unique fixed point to a contracting operator. In this paper we analyse allocation strategies under several families of utility functions, and highlight significant portfolio selection differences with previously reported results.
Special Issue: Giftedness, Disability, Gender and Well-Being in Higher Education: A Socio-Psycho- Pedagogical Perspective

Abstract Students’well-being in China seems to be insufficiently researched. This article reviews the recent literature on Chinese students’well-being to illustrate the relationship that exists between mental health and education as well as to identify implications for improving well-being. Eighteen articles published between 2012 and 2022 were reviewed and selected according to a systematic protocol. It was found that the reviewed papers focused on 4 areas: analyses of well-being in the context of implications for the study process, analyses of students’ wellbeing in the context of various characteristics yet without direct implications for the study process, studies of well-being conducted among medical students and in relation to Chinese students studying abroad.
Did outside directors’ firm-specific accumulated knowledge benefit the firm’s stock performance during COVID-19?

We examine whether outside directors’ firm-specific accumulated knowledge in the forms of human and internal social capital benefitted the firm during COVID-19. Using a sample of 754 US firms during the COVID-19 collapse period, we find an inverted U-shaped relation between outside directors’ average board tenure and cumulative excess stock returns. Our result suggests that firms experienced optimal cumulative excess stock returns during COVID-19 when outside directors’ average board tenure is 10 years. We also find that the curvilinear relation is profound for outside directors with more internal social capital, suggesting that outside directors’ internal social capital plays a prominent role in enhancing board effectiveness during a crisis. Furthermore, we use several robustness checks to confirm the results. JEL Classification: D83, G30, G34, M41
A transition density expansion for a multi-allele diffusion model

An expansion in orthogonal polynomials is found for the transition density in a neutral multi-allele diffusion model where the mutation rates of allele types A i → A j are assumed to be u j (≥ O). The density is found when the mutation rate is positive for all allele types, and when some or all have zero mutation. The asymptotic conditional density is found for a mixture of positive and zero mutation rates. The infinite alleles limit with equal mutation is studied. Eigenfunctions of the process are derived and the frequency spectrum found. An important result is that the first eigenfunction depends only on the homozygosity. A density for the time to fixation with zero mutation is found for the K allele, and infinite alleles model.
RESPON SISWA TERHADAP LEMBAR KERJA PESERTA DIDIK (LKPD) MATERI BIOTEKNOLOGI PRODUK FERMENTASI LOKAL DI SMA NEGERI

This study aims to determine students' responses to local fermented biotechnology Worksheets. This research was a type of qualitative descriptive research. Data collection used a questionnaire with Likert scale. Data trials were carried out with 2 scales, they are small scale of 8 respondents and large scale of 28 respondents. Based on the assessment of the results of the questionnaire that given to small-scale respondents, reached 89% in the very good category, while the large-scale respondents amounted to 87.81% in the very good category.
Development and validation of a transformer-based CAD model for improving the consistency of BI-RADS category 3–5 nodule classification among radiologists: a multiple center study

Background Significant differences exist in the classification outcomes for radiologists using ultrasonography-based Breast Imaging Reporting and Data Systems for diagnosing category 3–5 (BI-RADS 3–5) breast nodules, due to a lack of clear and distinguishing image features. Consequently, this retrospective study investigated the improvement of BI-RADS 3–5 classification consistency using a transformer-based computer-aided diagnosis (CAD) model. Methods Independently, 5 radiologists performed BI-RADS annotations on 21,332 breast ultrasonographic images collected from 3,978 female patients from 20 clinical centers in China. All images were divided into training, validation, testing, and sampling sets. The trained transformer-based CAD model was then used to classify test images, for which sensitivity (SEN), specificity (SPE), accuracy (ACC), area under the curve (AUC), and calibration curve were evaluated. Variations in these metrics among the 5 radiologists were analyzed by referencing BI-RADS classification results for the sampling test set provided by CAD to determine whether classification consistency (the k value), SEN, SPE, and ACC could be improved. Results After the training set (11,238 images) and validation set (2,996 images) were learned by the CAD model, the classification ACC of the CAD model applied to the test set (7,098 images) was 94.89% in category 3, 96.90% in category 4A, 95.49% in category 4B, 92.28% in category 4C, and 95.45% in category 5 nodules. Based on pathological results, the AUC of the CAD model was 0.924 and the predicted probability of CAD was a little higher than the actual probability in the calibration curve. After referencing BI-RADS classification results, the adjustments were made to 1,583 nodules, of which 905 were classified to a lower category and 678 to a higher category in the sampling test set. As a result, the ACC (72.41–82.65%), SEN (32.73–56.98%), and SPE (82.46–89.26%) of the classification by each radiologist were significantly improved on average, with the consistency (k values) in almost all of them increasing to >0.6. Conclusions The radiologist’s classification consistency was markedly improved with almost all the k values increasing by a value greater than 0.6, and the diagnostic efficiency was also improved by approximately 24% (32.73% to 56.98%) and 7% (82.46% to 89.26%) for SEN and SPE, respectively, of the total classification on average. The transformer-based CAD model can help to improve the radiologist’s diagnostic efficacy and consistency with others in the classification of BI-RADS 3–5 nodules.
What children need to flourish: insights from a qualitative study of children's mental health and wellbeing in the pandemic

ABSTRACT This study explored the impacts of the COVID-19 pandemic on the mental health and wellbeing of primary school aged children in the UK, through the perspectives of teachers and parents through surveys and interviews. Results highlighted the heterogeneity within children’s experiences and the detrimental impacts of the lockdowns on social development. Importantly, many participants also drew attention to the benefits of the less pressurised schooling, which were perceived as having a positive impact on behaviour, wellbeing and academic progress. The paper applies insights from the findings to the reimagining of primary education to support children’s flourishing post-pandemic. It contends that prioritising children’s social and emotional development is key to supporting children’s flourishing in the recovery period and is a prerequisite for effective learning more widely. However, the paper argues for a critical ecological approach to wellbeing in schools: while individualised interventions such as counselling may be part of the solution, what is needed is a deeper and longer-term transformation of the system in which time and capacity for fostering strong relationships and children’s active engagement are placed at the heart of primary education.
The Rare Adverse Effect of Cefepime-Induced Neutropenia

Cefepime is widely considered a safe and effective antibiotic, but it can have rare and serious side effects. We present a case of a 33-year-old female patient who developed severe and potentially life-threatening neutropenia after being on cefepime for 25 days. Despite extensive investigations, no other causes of neutropenia could be identified. Discontinuing the medication and administering a single dose of filgrastim produced a rapid and dramatic response. This case highlights the rare but serious risk of cefepime-induced neutropenia and underscores the need for clinicians to remain vigilant for this potential adverse effect. It is important to note that discontinuing the medication can rapidly reverse the effects, making timely recognition and intervention crucial for patient outcomes.
Finite element analysis of true and pseudo surface acoustic waves in one-dimensional phononic crystals

In this paper, we report a theoretical investigation of surface acoustic waves propagating in one-dimensional phononic crystal. Using finite element method eigenfrequency and frequency response studies, we develop two model geometries suitable to distinguish true and pseudo (or leaky) surface acoustic waves and determine their propagation through finite size phononic crystals, respectively. The novelty of the first model comes from the application of a surface-like criterion and, additionally, functional damping domain. Exemplary calculated band diagrams show sorted branches of true and pseudo surface acoustic waves and their quantified surface confinement. The second model gives a complementary study of transmission, reflection, and surface-to-bulk losses of Rayleigh surface waves in the case of a phononic crystal with a finite number of periods. Here, we demonstrate that a non-zero transmission within non-radiative band gaps can be carried via leaky modes originating from the coupling of local resonance.
Clinicopathological Study of 307 Patients with Lichen Planus Actinicus and Pigmentosus Referred to Razi Skin Hospital From 2016 to 2021

Introduction The two less-known subtypes of lichen planus (LP) are lichen planus actinicus (LPA) and lichen planus pigmentosus (LPP), with the highest prevalence in the Middle East. Objectives We aimed to evaluate the clinicopathological profile of these patients. Methods Three hundred and seven cases including 184 LPA and 123 LPP patients were recruited from the registered pathology reports of Razi Skin Hospital of Tehran from April 2016 to March 2021. The clinical features and pathological reports were extracted and analyzed. Results Among 307 patients, 117 (63.9%) in the LPA group and 88 (71.5%) in the LPP group were women. Duration of disease ranged from 1 month to 20 years and 1 month to 12 years in the LPA and LPP groups, respectively. Face (159 patients), limbs (68), and neck (23) were the most frequent sites of involvement in LPA patients, whereas face (60 patients), limbs (47), and trunk (42) were more commonly involved in the LPP patients. Pruritus and oral mucosal lesions were found with similar frequency in both groups. Pathological evaluation showed vacuolar degeneration of basal layer (100%), lymphocytes infiltration (97.3%), and melanin incontinence (58.2%) as the most frequent findings in LPA and vacuolar degeneration of basal layer (100%), lymphocytes infiltration (100%), and melanin incontinence (52/8%) as the most frequent findings in LPP cases. Conclusions LPA and LPP were both more prevalent among women. Face was the most common site of involvement in both LPA and LPP. Vacuolar degeneration, lymphocyte infiltration, melanin incontinence, and hyperkeratosis were more common histological findings in this study.
H ∞ model reduction for discrete time-delay systems: delay-independent and dependent approaches

This paper investigates the problem of H ∞ model reduction for linear discrete-time state-delay systems. For a given stable system, our attention is focused on the construction of reduced-order models, which guarantee the corresponding error system to be asymptotically stable and have a prescribed H ∞ error performance. Both delay-independent and dependent approaches are developed, with sufficient conditions obtained for the existence of admissible reduced-order solutions. Since these obtained conditions are not expressed as strict linear matrix inequalities (LMIs), the cone complementary linearization method is exploited to cast them into sequential minimization problems subject to LMI constraints, which can be readily solved in standard numerical software. In addition, the development of reduced-order models with special structures, such as delay-free models and zeroth-order models, is also addressed. The approximation methods presented in this paper can be further extended to cope with systems with uncertain parameters. Two numerical examples have been provided to show the effectiveness of the proposed theories.