Miracle-dz/UniFAR-FTUs huggingface dataset:
Regret Bounds for Noise-Free Kernel-Based Bandits

Kernel-based bandit is an extensively studied black-box optimization problem, in which the objective function is assumed to live in a known reproducing kernel Hilbert space. While nearly optimal regret bounds (up to logarithmic factors) are established in the noisy setting, surprisingly, less is known about the noise-free setting (when the exact values of the underlying function is accessible without observation noise). We discuss several upper bounds on regret; none of which seem order optimal, and provide a conjecture on the order optimal regret bound.
Assessment of Middle Ear Function during the Acoustic Reflex Using Laser-Doppler Vibrometry

Abstract : Over the past several years, recommendations have been made to update and/or replace current military standards and regulations intended to protect individuals exposed to high-level acoustic impulses from hearing injury. One method recently implemented by the Department of Defense for determining the risk of hearing injury from impulsive noise exposures is the Auditory Hazard Assessment Algorithm for Humans (AHAAH). The AHAAH is an electrical equivalence model of the human ear designed to reproduce sound transmission through the ear in order to predict potential hearing injury from a given sound exposure; however, several key assumptions involving the effects of middle-ear muscle contraction (MEMC) on sound transmission through the middle ear during the acoustic reflex have not been validated. In the current study, we used laser-Doppler vibrometry (LDV) to measure tympanic membrane (TM) motion in response to an acoustic reflex-eliciting impulse as a proxy for assessing ossicular chain motion in human participants. Using this approach, we are able to directly measure the time course and magnitude of engaging the MEMC on middle ear movement. Changes in ossicular chain motion during MEMC were thus observed as frequency-dependent increases or decreases in TM velocity. Preliminary results suggest a more nuanced, across-frequency potential for middle ear gain or attenuation during the acoustic reflex.
Citizen petition Sexual side effects of SSRIs and SNRIs

The undersigned submits this petition to request the Commissioner of Food and Drugs to immediately require the addition of boxed warnings, warnings, precautions, and highlights of prescribing information to the product label for all selective serotonin reuptake inhibitor (SSRI) and serotonin-norepinephrine reuptake inhibitor (SNRI) products, including branded and generic formulations. These include, but are not limited to, citalopram (Celexa), desvenlafaxine (Pristiq), duloxetine (Cymbalta), escitalopram (Lexapro), ﬂ uoxetine (Prozac), paroxetine (Paxil), sertraline (Zoloft), venlafaxine (Effexor), and vortioxetine (Trintellix).
Digital-Based Learning Application Model in Schools

— The rapid development of science and technology has been anticipated by the government through the Merdeka Belajar (freedom to learn) policy initiated by the Education and Culture Ministry of the Republic of Indonesia. One of the responses about that policy was the development of a digital-based learning application model. This study used a research design based on Resarch and Development (R&D). The purposes of this study is to develop a digital-based learning model that is able to provide freedom of learning for teachers and students in the digital learning process. The results showed that the digital-based learning model which its development was based on inputs in the form of an independent learning policy and the digitalization movement; element of process in the form of student-centered learning; element of output in the form of fun and flexible learning; and the element of intact results in the form of the establishment of student competencies.
Developing, Understanding and Evaluating Augmented Reality Framework for Universities in Saudi Arabia

— Technology has introduced new tools such as Augmented Reality (AR), the application of which may improve learning outcomes. AR is the integration of digital information with the user environment in real time. Despite the fact that technologies have been implemented in Saudi Arabia’s education sector, several issues exist that are associated with the traditional methods of teaching and learning i.e. students’ lack of motivation concerning independent learning, collaborative learning, and skills-acquisition, which are a part of the current pedagogy. To resolve the problems associated with traditional teaching and learning methods, the Augmented Reality approach will be examined and assessed in Saudi Arabia’s higher education sector, through the development of a new AR model. This research aims to develop, understand and evaluate the AR framework in order to determine the factors ( e.g., willingness, perception, motivation, and acceptance) that will have the most influence on AR adoption especially regarding students’ learning outcomes in Saudi Arabia. A set of recommendations will be suggested for the adoption of AR in Saudi Arabia’s higher education sector. This study will employ a mixed-methods research design (Explanatory Sequential Design), whereby the data will be collected using both quantitative (online survey) and qualitative methods (semi-structured interviews).
The impact of job security on job satisfaction and organisational commitment at Femina Garments in Zimbabwe : a case study

The overall aim of the study was to investigate the impact of job insecurity on job satisfaction and organisational commitment at Femina Garments in Zimbabwe. Job insecurity has increased considerably over the recent decade in the clothing industry of Zimbabwe. Negative economic growth, retrenchments and company closures have led to job insecurity increase in Zimbabwe. Against this background, the literature suggests that job insecurity has a negative impact on different job attitudes. The study was conducted at Femina Garments, a clothing manufacturing company in Zimbabwe. The study adopted the quantitative research design and a survey method was employed for all 109 employees at Femina Garments. A structured closed-ended questionnaire was used to collect data. A significant response rate of 93.58% was obtained using the personal method of data collection. The responses to the questionnaire were captured and analysed using the Statistical Package for Social Sciences (SPSS) version 24.0 for Windows. Several hypotheses were formulated and tested using the Pearson`s chi-square and Spearman`s rank order correlation co-efficient. The main findings revealed that job insecurity did have an impact on organisational commitment. The findings also revealed that job insecurity had no relationship with job satisfaction at Femina Garments. The recommendations suggest that management at Femina Garments should provide clear communication, provide social support and maintain a balanced psychological contract. The recommendations also suggest that management at Femina Garments should provide salaries and benefits that are market related. The study concludes by providing directions for future research.
ECTOMYCORRHIZAL ACTIVITY AND CONIFER GROWTH INTERACTIONS IN WESTERN-MONTANE FOREST SOILS

The distribution of ectomycorrhizal activities in forest soils and their potential interactions with conifer growth in a variety of ecological/age / treatment situations are described. In old-growth ecosystems ectomycorrhizal roots are concentrated in organic soil horizons. In planted situ ations positive correlations between early seedling growth and ectomycorrhizal activity were consistent the first year and most often associated with high organic matter soils and competition thereafter. Potential effects of a variety of management actions on soil-related ectomycorrhizal inputs to productivity, and the opportunities for ectomy corrhizal technology to improve early performance in re generated forest stands are discussed.
Survival Processing Effects in Visual Long-Term Memory

Survival processing, where participants are asked to rate words for their relevance in survival scenarios compared to ratings for pleasantness, has been repeatedly shown to be a very effective way of enhancing verbal long-term memory. Given that cues for survival should be driven by visual information, we asked whether or not a similar survival advantage can be found for visual objects in visual long-term memory (VLTM). Participants rated coloured images of real-world objects for sharpness, pleasantness, and relevance to survival. Participants then completed a surprise colour recall test where they were shown greyscale versions of the objects and indicated each object’s previous colour on a colour wheel. Mixture modelling was used to analyze the responses. No survival advantage was found; objects rated for relevance in the survival scenario did not demonstrate greater resolution in comparison to the other conditions.
Amorphous Oxide Thin Film Transistors with Nitrogen-Doped Hetero-Structure Channel Layers

The nitrogen-doped amorphous oxide semiconductor (AOS) thinfilm transistors (TFTs) with double-stacked channel layers (DSCL) were prepared and characterized. The DSCL structure was composed of nitrogen-doped amorphous InGaZnO and InZnO films (a-IGZO:N/a-IZO:N or a-IZO:N/a-IGZO:N) and gave the corresponding TFT devices large field-effect mobility due to the presence of double conduction channels. The a-IZO:N/a-IGZO:N TFTs, in particular, showed even better electrical performance (µFE = 15.0 cm2・V−1・s−1, SS = 0.5 V/dec, VTH = 1.5 V, ION/IOFF = 1.1 × 108) and stability (VTH shift of 1.5, −0.5 and −2.5 V for positive bias-stress, negative bias-stress, and thermal stress tests, respectively) than the a-IGZO:N/a-IZO:N TFTs. Based on the X-ray photoemission spectroscopy measurements and energy band analysis, we assumed that the optimized interface trap states, the less ambient gas adsorption, and the better suppression of oxygen vacancies in the a-IZO:N/a-IGZO:N hetero-structures might explain the better behavior of the corresponding TFTs.
T and B Lymphocyte Chemokinesis Synergize with Adhesion Ligands to Trigger Homeostatic Lymphoid Chemokines

Homeostatic chemokines such as CCL19, CCL21, and CXCL13 are known to elicit chemotaxis from naive T and B cells and play a critical role in lymphocyte homing to appropriate zones within secondary lymphoid organs (SLO). Here we tested whether CCL21 and CXCL13 modulate murine lymphocyte motility in the absence of concentration gradients, using videomicroscopy to directly observe the migration of single cells. CCL21 treatment of T cells induced rapid polarization and sustained random migration with average speeds of 5.16 (cid:1) 2.08 (cid:2) m/min; B cell migration (average velocity 4.10 (cid:1) 1.58 (cid:2) m/min) was similarly induced by CXCL13. Migration required the presence of both chemokine and adhesion ligands and was sustained for > 24 h. Furthermore, in in vitro assays modeling the relative infrequency of Ag-speciﬁc T cell-dendritic cell (DC) encounters during primary immune responses, we found that CCL21 addition to T-DC cocultures accelerated the kinetics of CD69 up-regulation and enhanced by 2-fold the proliferation of Ag-speciﬁc T cells in a manner dependent on G-protein-coupled receptor signaling in T cells. These results suggest that homeostatic chemokines could substantially impact the dynamics and priming of lymphocytes within SLO even in the absence of signiﬁcant concentration gradients. The Journal of Immunology, 2006, 177: 2340–2348. ime-lapse ﬂuorescence imaging of intact murine lymph nodes has revealed that T and B cells exhibit dramatic, sustained motility during homeostasis and during some phases of Ag priming, which may be critical for efﬁcient Ag surveillance (Refs.
CEG_A_288688 91..102

Disciplina de Gastroenterologia, Escola Paulista de Medicina, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil Background: Crohn’s disease (CD) and ulcerative colitis (UC) are chronic inflammatory diseases of the gastrointestinal tract with an increasing incidence in developing countries. Purpose: To report clinical and demographic data of CD and UC at a referral center for inflammatory bowel disease (IBD) in São Paulo. Patients and Methods: We conducted a retrospective cross-sectional study on adult patients with established IBD. Demographic and clinical data were obtained by medical records analysis from the IBD Outpatient Clinic of EPM-UNIFESP, from October 1997 to October 2017. Results: Of 658 patients included, 355 had UC (54%) and 303 had CD (46%). UC was more prevalent in women than CD (219 [61.7%] vs 152 [50.2%], p=0.003). The median time between the onset of symptoms and diagnosis was 13 (5–38) months, with a longer duration for CD patients. CD mostly affected the ileocolonic location (47.9%). CD patients with stricture, fistula and/or perianal disease (213/303, 70.3%) were younger at diagnosis, had a longer disease duration, higher rates of corticosteroid, immunomodulatory, and biological therapy, hospitalization, and referral to surgery, compared to patients without complication. Extensive colitis was the most common extension of UC (50.6%), which was more frequently associated with younger age at diagnosis, hepatobiliary disease, increased need for hospitalization, higher use of immunomodulatory, and biologic therapy, compared to patients with less extensive disease. In the last 5 years, CD patients were more frequently on biologic and/or immunomodulatory (70.9%) therapy, and UC patients often received salicylates (78.1%) and immunomodulatory (28.1%) treatments. There was a consistent reduction in salicylate usage for CD in the last 5 years compared to the total period of follow-up. Conclusion: Despite the increasing incidence, we highlight the diagnostic delay and a more complicated CD and extensive UC in this cohort, reflecting a high need for immunomodulatory and biological treatment, hospitalization, and surgery.
Association between Serum Vitamin A Levels and Premature Ovarian Insu�ciency Risk

Purpose: The aim of the study was to explore the association between serum vitamin A levels and premature ovarian insu�ciency (POI). Methods: In this cross-sectional survey, women with POI (n = 47) and normo-ovulatory controls (n = 67) were enrolled from December 2016 to May 2018 in Zhejiang, China. The serum levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E 2 ), anti-Müllerian hormone (AMH), vitamin A, and total cholesterol (TC) were measured for each participant. The association of vitamin A levels with POI risk was assessed using binary logistic regression analysis. Results: Serum vitamin A levels seems slightly higher in the POI group than in the control group (728.00 ± 176.00 vs 503.93 ± 145.64 µg/L, p = 0.133). But after adjust with serum lipid level, serum vitamin A/TC ratio was signi�cantly lower in the POI group than in the control group (143.14 ± 35.86 vs 157.56 ± 35.21 µg/mmol, p = 0.035). Further, serum vitamin A/TC ratio was signi�cantly and negatively associated with POI risk [unadjusted odds ratio (OR) = 0.988, 95% con�dence interval (CI): 0.977–0.999, p = 0.039]. The same trend was found after adjusting for confounding factors (age, BMI, annual household income, and education) (OR = 0.986, 95% CI: 0.972–0.999, p = 0.040). Conclusion: Serum vitamin A/TC ratio was negatively associated with POI risk, indicating that vitamin A de�ciency may be a risk factor for POI development. Serum vitamin A/TC ratio may serve as a predictive factor for POI incidence. Thus, vitamin A may serve a protective role in ovarian tissue. as mean ± SD). Continuous variables with normal distributions were compared using Student’s t-test. Continuous variables with non-normal distribution were compared using Mann–Whitney U test. Categorical variables were presented as number and percentage and compared using chi-square test. The correlations of each variable with POI were assessed with Spearman nonparametric correlation analysis. The association between the TC-adjusted vitamin A levels and POI risk was further assessed using binary logistic regression analysis. All statistics were two-tailed, and p < 0.05 was considered signi�cant.
On oscillations of the Earth’s fluid core

Summary. In the conventional spheroidal and toroidal representation, the differential equations governing long-period free oscillations of the Earth’s fluid core form an infinitely coupled system. Because of the mathematical complexity, solutions of this system are customarily attempted by numerical integration. The approach, however, necessitates a severe truncation of the coupling chain and this, in turn, renders it difficult to interpret the results. An alternative approach is sought in this work. By invoking the ‘solenoidal flow’ approximation which neglects the dilatation, and the ‘subseismic’ approximation which neglects the flow pressure respectively, we have succeeded in developing analytic solutions for the inertial and gravitational oscillations. This results in a significant simplification of the eigenvalue problem because the infinitely coupled system of differential equations is now reduced to an algebraic one. More importantly, the analytic solutions reveal immediately the roles played by the rotation and density stratification in core dynamics. We find that the inertial oscillations, which arise from the Earth’s rotation, are essentially independent of the core’s density stratification. Thus the fluid core can be approximated by a homogeneous, incompressible and non-gravitating inviscid Newtonian fluid with only minor modifications. The gravitational oscillations, on the other hand, are governed by both the rotation and density stratification. In a non-rotating earth, gravitational oscillations are not possible for neutrally or unstably stratified cores. Because of rotation, however, gravitational oscillations become possible for any density stratification in the core, and the eigenfrequencies are divided into alternating allowed and forbidden zones. We show that in each allowed zone, there exist an infinite number of gravitational oscillations with their eigenfrequencies approaching asymptotically
Microsoft Word-nzaa152.docx

Background: Regression to the mean (RTM) is a statistical phenomenon where second measurements are more likely to be closer to the mean. This is particularly observed in those with baseline values further from the mean. Anemic individuals (hemoglobin <120g/L) are often recruited when evaluating iron supplementation programs, as they are more likely to elicit a greater hemoglobin response; however, they are also at greater risk for RTM as their baseline values are lower than the overall population mean. Objective: To calculate and apply RTM to a previously conducted iron supplementation trial of women in Cambodia at increasingly severe baseline anemia cut-offs (hemoglobin <120g/L, <115g/L and <110g/L). Methods: Women received either 60mg/day iron ( n =191) or placebo ( n =185) for 12 weeks. Hemoglobin was measured at baseline and 12 weeks (endline), and change in hemoglobin was calculated in each group, for each cut-off. RTM was calculated in the placebo group at each cut-off and applied to the change observed at each cut-off in the iron group to obtain the RTM-free effect. Results: In the placebo group, mean change in hemoglobin increased as cut-offs became more extreme (0.9g/L to 1.9g/L in those with baseline hemoglobin <120g/L and <110g/L, respectively). RTM estimates similarly increased: 1.0g/L (<120g/L), 1.3g/L (<115g/L), and 1.8g/L (<110g/L). When applying RTM to the iron group, we found that ~10% of the “treatment effect” could be attributable to RTM at each cut-off. However, iron supplementation was still effective in increasing hemoglobin, with an increased effect in those with lower baseline values, as proven by the RTM-free effect hemoglobin following iron supplementation; however, appropriate use of a placebo group in the statistical analyses of the trial controls for this potential RTM effect. quantify the effect of iron on repeat hemoglobin measures in those with increasing severity of anemia at baseline (hemoglobin <120 g/L, <115 g/L and <110 g/L); and 2) to apply RTM estimates to the treatment effect of iron on hemoglobin for estimation of the RTM-free effect. We hypothesized that as baseline anemia values became more severe, we would observe an increased change in hemoglobin from baseline to 12 weeks (endline), which may be partially explained by RTM.
A Novel Anti-in ammatory D-peptide Halts Disease Phenotype Progression in an ALS Mouse Model

Julia Post Forschungszentrum Jülich GmbH Vanessa Kogel Forschungszentrum Jülich GmbH Anja Schaffrath Forschungszentrum Jülich GmbH Philipp Lohmann Forschungszentrum Jülich GmbH Nadim Joni Shah Forschungszentrum Jülich GmbH Karl-Josef Langen Forschungszentrum Jülich GmbH Dieter Willbold Forschungszentrum Jülich GmbH Antje Willuweit Forschungszentrum Jülich GmbH Janine Kutzsche (  j.kutzsche@fz-juelich.de ) Forschungszentrum Julich GmbH https://orcid.org/0000-0003-0271-7390
Genome-wide detection and sequence conservation analysis of long non-coding RNA 1 during hair follicle cycle of yak 2

24 Background: Long non coding RNA (lncRNA) as important regulator has been demonstrated playing an 25 indispensable role in the biological process of hair follicles (HFs) growth. However, their function and 26 expression profile in hair cycling of yak are yet unknown. It only a few functional lncRNAs have been 27 identified, partly due to the low sequence conservation and lack of identified conserved properties in 28 lncRNAs. Here, lncRNA-seq was employed to detect the expression profile of lncRNAs during HFs cycle 29 of yak, and the sequence conservation between yak and cashmere goat during HFs cycle was analyzed 30 Result: Totally 2884 lncRNAs were identified in five phases (Jan. Mar. Jun. Aug. and Oct.) during HFs 31 cycle of yak. We then performed differential expression analysis between three phases (Jan. Mar. and Oct.) 32 finding that 198 differently expressed lncRNAs (DELs) were obtained in Oct-vs-Jan, 280 DELs were 33 obtained in Jan-vs-Mar, and 340 DELs were obtained in Mar-vs-Oct. Subsequently, the nearest genes of 34 DELs were used to explore the potential function of lncRNAs by GO and KEGG enrichment analysis, 35 several critical pathways involved in HFs development such as Wnt signaling pathway, VEGF signaling 36 pathway and Signaling pathways regulating pluripotency of stem cells were enriched. To further screen key 37 lncRNAs influencing in HFs cycle, twenty-four sequence conserved DELs were obained via comparison 38 analysis of partial DELs with previously published lncRNA-seq data of cashmere goat in HFs cycle by 39 NCBI blast-2.9. 0+, and the limited degree of sequence conservation of lncRNAs were observed . 40 Conclusion: Our study expanded the knowledge about lncRNAs affecting on hair cycling, and the finding 41 related to sequence conservation properties of lncRNAs between two species at the specific trait- HFs cycle 42 will likely provide valuable insights into the study of lncRNAs functionality and mechanism. follicle between yak and cashmere goat provided us a good animal model for the sequence conservation study of lncRNAs in the same trait.