Miracle-dz/UniFAR-FTUs huggingface dataset:
Radiotherapy and Limb-Sparing Surgery in the Management of Localized Soft Tissue Sarcomas: Tertiary Care Center Experience From Pakistan

PURPOSE When combined with radiotherapy, limb salvage surgery is an alternative to amputation. This study sought to determine the limb-sparing treatment outcomes in patients diagnosed with soft tissue extremity sarcomas treated at our institution. MATERIALS AND METHODS All adult patients with extremity soft tissue sarcoma treated with the radical limb salvage strategy at Shaukat Khanum Memorial Cancer Hospital and Research Canter, Lahore, Pakistan, between January 2017 and December 2019 were retrospectively assessed. RESULTS A total of 122 patients were included in the study. The mean age was 42 years (range 19-82), and 64 (52.5%) were males. The majority of patients, 65 (53.3%), were diagnosed with stage III and grade III disease according to American Joint Committee on Cancer TNM classification (Eighth edition). The most common surgical modality was wide local excision that was performed in 106 (86.9%) patients. Adjuvant radiation treatment was given in 111 (91%) patients, whereas 11 (9%) patients received neoadjuvant radiation treatment. The mean dose was 58 Gy (range: 46-66 Gy). Eighty-two (67.2%) of the patients were disease-free on post-treatment radiologic scans with disease recurrence observed in 40 (32.8%) patients. The median disease-free survival was 8 months (95% CI, 5.45 to 10.55). Local recurrence and distant metastases developed in 16 (13%) and 24 (20%) patients, respectively. CONCLUSION About two thirds of patients with extremity soft tissue sarcoma were successfully treated with limb salvage strategy, surgery, and radiation therapy. However, high rate of relapse warrants further novel strategies in this patient population.
Anti-nucleosome antibodies in patients with systemic lupus erythematosus of recent onset. Potential utility as a diagnostic tool and disease activity marker.

OBJECTIVE To compare the utility of anti-chromatin antibodies for the diagnosis of systemic lupus erythematosus (SLE) and as markers of disease activity. METHODS We included 73 consecutive patients (62 female) with SLE (four or more ACR criteria) of recent onset (<1 yr since diagnosis). As control groups we included 130 healthy blood donors and 261 patients with 11 systemic autoimmune diseases (SAD). Disease activity was assessed using the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI). A venous blood sample was drawn to measure three anti-chromatin antibodies [anti-nucleosome (anti-NCS), anti-double-stranded DNA (anti-dsDNA) and anti-histones (anti-HST)] by enzyme-linked immunosorbent assay. RESULTS The prevalence of anti-chromatin antibodies in SLE patients and healthy controls was 100 and 3% respectively for anti-NCS, 63 and 5% for anti-dsDNA, and 15 and 3% for anti-HST. Anti-NCS had a sensitivity of 100% and specificity of 97% for SLE diagnosis. When SLE and SAD patients were compared [excluding mixed connective tissue disease (MCTD)], the sensitivity of anti-NCS, anti-dsDNA and anti-HST antibodies for SLE diagnosis was 93, 71 and 40% respectively and the specificity was 97, 98 and 98%. Anti-chromatin antibodies were not useful in differentiating between SLE and MCTD patients. Anti-NCS antibodies showed the highest correlation with disease activity (r = 0.45, P < 0.0001), especially in patients negative for anti-dsDNA antibodies (r = 0.58, P = 0.001). Anti-NCS antibodies also showed strong association with renal damage (odds ratio 4.1, 95% confidence interval 1.2-13.6, P = 0.01). CONCLUSION Anti-NCS antibodies could be a useful tool in the diagnosis and assessment of disease activity in SLE patients, especially in patients who are negative for anti-dsDNA antibodies.
Investigation of a turbulent channel flow using large eddy simulation

The LES of a compressible turbulent channel flow is performed at a Mach number of 0.5 and a friction Reynolds number $Re_{\tau}=u_{\tau}h/\nu$ around 300, where $u_{\tau}$ is the friction velocity and $h$ is the half-width of the channel. Explicit low-dissipation numerical schemes are employed for spatial derivatives and time integration. Nine simulations are carried out on grids with different mesh spacings in order to study the mesh convergence of turbulence statistics, regarding the mean and fluctuating streamwise velocity profiles. These quantities are found to not vary significantly for mesh spacings smaller than 7.5 and 30 wall units in the spanwise and streamwise directions, respectively. An additional simulation is performed using a semi-implicit Runge-Kutta algorithm, which has been developed for wall-bounded flows. With this algorithm, terms involving wall-normal derivatives are integrated implicitly, while the other terms are integrated explicitly. Thus, the CFL constraint in the wall-normal direction is relaxed. The simulations finaly provide a numerical database, from which wall pressure, wall shear stress and velocity spectra are computed to give insights into the structures developing in the flow.
The minimal non-Koszul A(Γ)

ABSTRACT The algebras A(Γ), where Γ is a directed layered graph, were first constructed by Gelfand et al. [5]. These algebras are generalizations of the algebras Qn, which are related to factorizations of non-commutative polynomials. It was originally conjectured that these algebras were Koszul. In 2008, Cassidy and Shelton found a counterexample to this claim, a non-Koszul A(Γ) corresponding to a graph Γ with 18 edges and 11 vertices. We produce an example of a directed layered graph Γ with 13 edges and 9 vertices, which produces a non-Koszul A(Γ). We also show this is the minimal example with this property.
Evaluation of clinical outcomes after COMBO stent treatment in patients presenting with acute coronary syndrome

Patients presenting with acute coronary syndrome (ACS) are at increased risk of complications after percutaneous coronary intervention with stent placement compared to patients with stable angina (SA) treated in an elective setting. The novel pro‐healing COMBO stent is a bio‐engineered drug eluting stent designed to promote vessel healing. Therefore, the stent may reduce this difference in clinical outcomes between elective and ACS‐patients and prevent late stent thrombosis.
Agriculture and Biology Journal of North America Biological Control of Bean Root Rot Disease Caused by Rhizoctonia Solani under Green House and Field Conditions

This study was carried out to evaluate the efficiency of the biocontrol agents Trichoderma harzianium, Glomus intraradices and Azotobacter chroococcum to protect bean, Phaseolus vulgaris L. plants against Rhizoctonia solani, causative agent of root rot under different conditions. Results obtained showed that the disease was distributed in all bean cultivated area of Babylon city-Iraq and R. solani was detected in most tested samples. It has been found that R. solani had effects on bean seed germination and plant growth. Result of differential hosts revealed that R. solani isolates obtained belong to anastomosis groups 4 (AG-4) and this confirmed by the result of the dual culture test on PSA medium. Four isolates of Azotobacter chroococcum, isolated from wheat, bean and sesban, Sesbania sesban L. showed high antagonistic activity against the higher pathogenic isolate of R. solani (RS-3) on PSA medium. Arbuscular mycorrhizal, G. intraradices significantly reduced the disease incidence and severity in bean plants, The combination A. chroococcum with G. intraradices found to be more effective, than each of them separately, in decreasing disease incidence and severity under green house and field conditions. T. harzianium exhibited high activity in controlling the disease and increasing yield. All biocontrol agents used in this study improved plant growth and increased yield. The biocontrol agents may play an essential role in management of root rot diseases. INTRODUCTION Rhizoctonia solani Kühn [teleomorph: Thanatephorus cucumeris (Frank) Donk. ] isolates were divided to 14 anastomosis groups (AG1-AG13) and AG-bridging isolate (AG-BI), according to anastomosis reactions between them solani is a soilborne pathogen can attacks wide range of plants species such as bean causing seed decay and damping off, hypocotyl rot, root rot and web blight (Ogoshi,1976; Abawi et al. 1985). Trichoderma species have reported to be as potent biocontrol agent against various phytopathogenic soil fungi including R. The efficiency of T. harzianium to inhibit fungal growth may be through competition for space and nutrients, mycoparasitism and production of antibiotic compounds, it has found that the hyphae of T. harzianium coil around the hyphae of the pathogen and penetrate the host mycelium through degrading cell wall by secretion hydrolytic enzymes followed by assimilation of cell contents (Harmann et al.
Metronomic Chemotherapy

Simple Summary The present article reviews the state of the art of metronomic chemotherapy use to treat the principal types of cancers, namely breast, non-small cell lung cancer and colorectal ones, and of the most recent progresses in understanding the underlying mechanisms of action. Areas of novelty, in terms of new regimens, new types of cancer suitable for Metronomic chemotherapy (mCHT) and the overview of current ongoing trials, along with a critical review of them, are also provided. Abstract Metronomic chemotherapy treatment (mCHT) refers to the chronic administration of low doses chemotherapy that can sustain prolonged, and active plasma levels of drugs, producing favorable tolerability and it is a new promising therapeutic approach in solid and in hematologic tumors. mCHT has not only a direct effect on tumor cells, but also an action on cell microenvironment, by inhibiting tumor angiogenesis, or promoting immune response and for these reasons can be considered a multi-target therapy itself. Here we review the state of the art of mCHT use in some classical tumour types, such as breast and no small cell lung cancer (NSCLC), see what is new regarding most recent data in different cancer types, such as glioblastoma (GBL) and acute myeloid leukemia (AML), and new drugs with potential metronomic administration. Finally, a look at the strategic use of mCHT in the context of health emergencies, or in low –and middle-income countries (LMICs), where access to adequate healthcare is often not easy, is mandatory, as we always need to bear in in mind that equity in care must be a compulsory part of our medical work and research.
¿Es capaz “ChatGPT” de aprobar el examen MIR de 2022? Implicaciones de la inteligencia artificial en la educación médica en España

Artificial intelligence and natural language processing models have made an entrance into the field of medical education. Among them, the ChatGPT model has been used to try to solve different international medical exams. However, there is no literature which addresses this phenomenon in Europe or other Spanish-speaking countries. The present paper aims at evaluating the ability to answer questions of the ChatGPT model in the 2022 MIR, which grants access to the Spanish postgraduate training system. To this end, a cross-sectional descriptive analysis has been carried out in which all the questions of the 2022 MIR exam have been solved by this technology. ChatGPT was able to answer 51.4% of the questions correctly, which is approximately 69 net answers on said exam. According to estimates for this year, it would have obtained a 7688 position, which would be slightly below the population’s median, but would allow it to pass the cut-off score and choose a large number of specialties. These results are similar to those obtained in the existing literature, slightly worse to those obtained by this tool in the American USMLE exams. The development of AI is an opportunity for medical students and residents to learn, but it is also a risk in many ways. It is essential to train future specialists in the new reality of artificial intelligence so that they are able to use them and obtain benefits in a reasoned and safe manner. La inteligencia artificial y los modelos de procesamiento de lenguaje natural han irrumpido con fuerza en el ámbito de la educación médica. Entre ellos, el modelo ChatGPT ha sido utilizado para intentar resolver distintos exámenes de medicina a nivel internacional. Sin embargo, prácticamente no existe literatura en Europa ni países de habla hispana. El presente trabajo pretende evaluar la capacidad de responder preguntas del modelo ChatGPT en el examen MIR 2022. Para ello, se ha llevado a cabo un análisis transversal y descriptivo en el que se han introducido la totalidad de las preguntas del examen MIR 2022 en dicho modelo. ChatGPT ha sido capaz de responder de manera acertada un 51,4% de las preguntas, lo que supone aproximadamente 69 netas en el examen MIR. Según estimaciones para este año, obtendría un 7688, lo que estaría ligeramente por debajo de la mediana de la población presentada, pero que le permitiría pasar la nota de corte y escoger un gran número de especialidades. El resultado es similar a los obtenidos en la bibliografía previa, ligeramente por debajo de los resultados obtenidos por dicha herramienta en los exámenes americanos USMLE. Este tipo de modelos suponen una oportunidad para el aprendizaje de los estudiantes de medicina y los residentes, pero también supone un riesgo en muchos sentidos. Es fundamental formar a los futuros especialistas en la nueva realidad de la inteligencia artificial para que sean capaces de utilizarlas y obtener beneficios de manera razonada y segura.
The impact of an adventure based experiential learning programme on the life effectiveness of black high school learners

The aim of this study was to determine the effect of an adventure based experiential learning programme (AEP) in developing the life effectiveness of black high school learners. “Life Effectiveness” reflects the psychological and behavioural aspects of human functioning which determine the proficiency of a person in society. A total of eighty learners (forty boys and forty girls) aged between 12 and 17 years participated in this programme. They were categorized into an experimental (n = 40) and control group (n = 40). The experimental group participated in a five day AEP in the Vredefort Dome in the North-West Province. “The Life Effectiveness Questionnaire” (LEQ-H) was administered before, directly after and six months after the intervention programme to determine the immediate and long term effects of the AEP. Results for total life effectiveness for the short and long term for the experimental group indicated effect sizes of d = 0.03 and d = -0.03, respectively, while for the control group d = 0.12 and d = -0.06 was, respectively obtained. The intergroup results for the experimental and control categories, yielded overall medium effect sizes of d = 0.35 and d = 0.49 over the short and long term respectively, after comparing the adjusted means. The AEP promoted beneficial short and long term changes in the experimental group in contrast to the control category.
How can a high-quality genome assembly help plant breeders?

Abstract The decreasing costs of next-generation sequencing and the improvements in de novo sequence assemblers have made it possible to obtain reference genomes for most eukaryotes, including minor crops such as the blueberry (Vaccinium corymbosum). Nevertheless, these genomes are at various levels of completeness and few have been anchored to chromosome scale and/or are haplotype-phased. We highlight the impact of a high-quality genome assembly for plant breeding and genetic research by showing how it affects our understanding of the genetic architecture of important traits and aids marker selection and candidate gene detection. We compared the results of genome-wide association studies and genomic selection that were already published using a blueberry draft genome as reference with the results using the recent released chromosome-scale and haplotype-phased blueberry genome. We believe that the benefits shown herein reinforce the importance of genome assembly projects for other non-model species.
Folate Levels in Burning Tongue

It can be recognized that some hematological abnormalities are involved in burning tongues. The aim of this study was to compare folate levels between patients with burning tongue and healthy control group. Twenty-nine patients with tongue symptoms were enrolled in this study. They were compared with 21 healthy volunteers. Complete blood counts, hemoglobin typing, serum and red cell folate, and serum vitamin B12 levels were investigated. Medication taking and systemic diseases in all subjects were recorded. The results showed that 13 out of 29 patients (44.83%) had low red cell folate levels, whereas all healthy subjects had normal red cell folate levels. Patients with low red cell folate levels were defined as folate deficiency (n=6), folate deficient erythropoiesis (n=2) and folate depletion (n=5). There was a significant difference in red cell folate levels between two groups (p=0.000). Interestingly, 11 out of 29 patients with low red cell folate levels showed various tongue appearances such as geographic, fissured, coated, atrophic and foliate papillitis. Only 2 cases of burning tongue with normal appearance revealed low red cell folate levels. Moreover, there was no significant difference in red cell folate levels between medication and non medication taking patients (p=0.534). This study showed an association between red cell folate level and burning tongue but no association was observed between folate levels and any attendant systemic condition or prescribed medication.
Liquid Warping GAN: A Unified Framework for Human Motion Imitation, Appearance Transfer and Novel View Synthesis (Supplementary Material)

1. Details of Network Architecture All codes and dataset are available on this site1. Generator. The generator, as shown in Fig. 1, consists of three streams. One of them is named GBG for background inpainting, and the other two streams are source identity stream, namely GSID and transfer stream, namely GTSF . The GBG is a ResNet [2] and it contains three parts, encoder, residual blocks and decoder. The encoder firstly uses a 7×7×64 stride-1 convolution. Then, it follows three 3×3 stride-2 convolutions with 128, 256 and 512 filters, respectively. 6 residual blocks with 3× 3× 512 convolutions are used. The decoder contains three 3 × 3 transposed convolutions whose number of filters are 256, 128 and 64 respectively, are thereby utilized to upscale the feature resolution. The GSID and GTSF have a similar architecture with GBG, but they contain additional U-Net like skip connections. For GBG stream, it directly regresses the inpainted images Îbs in the final convolution layer. For GSID and GTSF steam, they regress a color map P and an attention map A in the final convolution layer. We apply instance normalization and ReLU on all convolutions and transposed convolutions, except for the last layer. Discriminator. It firstly uses a 4 × 4 × 64 stride-1 convolution and is followed by three stride-2 convolutions. All these convolutions utilize instance normalization and LeakyReLU with 0.2 negative slopes. The last layer is 4× 4× 1 convolution, which regresses the final score.
Effect of Lactic Acid Bacteria-Fermented Mulberry Leaf Extract on the Improvement of Intestinal Function in Rats

This study examined the laxative effects of mulberry leaf extract (MLE) fermented by lactic acid bacteria (LAB), which contains high levels of polyphenolic and flavonoid compounds, against loperamide-induced constipation in rats. Sprague-Dawley rats were divided into a normal group (N) and three experimental groups; loperamide treated group (C), loperamide and LAB-fermented MLE 300 mg/kg treated group (MLEL), and loperamide and LAB-fermented MLE 600 mg/kg treated group (MLEH). After 33 d, fecal pellet amount, fecal weight, water content of fecal, gastrointestinal transit time and length, and serum lipid profiles were measured. Constipation was induced via subcutaneous injection of loperamide (2.0 mg/kg b.w., twice a day) for the final 5 d of the experiment. After loperamide administration, the LAB-fermented MLE groups showed a significantly increase in the fecal pellets number, wet weight, and water content in rats compared with the C group. Moreover, increases in the intestinal length and viable Lactobacillus numbers in the feces were observed in the LAB-fermented MLE groups. The intestinal transit time was shorter in the LAB-fermented MLE groups than in the C group. In addition, the LAB-fermented MLE groups showed a significant decrease in triglyceride and total cholesterol levels and an increase in HDL-cholesterol level. These results indicated that oral administration of LAB-fermented MLE shows laxative effect in loperamide-induced constipated rats.
Supplementary Table 2

CGG–FXTAS isolated h. brain nuclei (frontal cortex) (113 CGG) biotinylated riboprobes targeting coding (~1.1 kb), 5’ UTR with CGG repeat (~0.3 kb) and 3’UTR (~2 kb) of FMR1 RNA A single-spot nuclear signal of enlarged size with either of the antisense probes; 6-11% of probed nuclei had inclusions: 28 out of 507 nuclei were 5’UTR probe positive, 42 out of 466 were positive for coding probe and 50 out of 471 nuclei were 3’UTR probe positive NA Tassone F 2004
Intermittent complexity fluctuations during ventricular fibrillation

Ventricular fibrillation is a lethal cardiac arrhythmia that is one of the major causes of death worldwide. A prevalent treatment is the application of a high-energy shock using a cardiac defibrillator. These defibrillation shocks can cause severe pain and might injure the cardiac tissue further, leading to an increased risk for future cardiac arrhythmias. Understanding the mechanisms leading to and sustaining lethal arrhythmias can help to develop improved defibrillation methods. The research questions of this thesis focus on the investigation of complexity fluctuations in the electrocardiogram during ventricular fibrillation and their relation to the spatiotemporal dynamics of electrical excitation waves that drive the contraction of the heart. Using experimental data employing optical mapping and data from cardiac simulations these complexity fluctuations are quantified and characterized using different complexity measures. It is found that periods of low complexity in the ECG can be associated with more organized states with a low number of scroll waves in simulated excitable media. The application of an experimental protocol using low energy shocks targeted at periods of specific complexity in ex vivo experiments using rabbit and pig hearts is presented. While a significant advantage when pacing into low complexity regimes could not be found, one possible reason for this result could be identified: Using multi electrode electrocardiogram data from cardiac simulations it was revealed that there can be a strong dependency of the measurements of complexity fluctuations on the angle of observation. By analysing the surface activity on the simulated heart details about the mechanism behind this heterogeneity were identified. Furthermore, the relation between the spatiotemporal complexity and the complexity observed by external electrodes is quantified for different numbers of electrodes. The implications for the development of angle-resolved measurement devices for complexity are analysed and discussed and provide the basis for future multi-channel complexity measurements.