Miracle-dz/UniFAR-FTUs huggingface dataset:
Association of Wider Social Environment with Relapse in Schizophrenia: Registry Based Six-Year Follow-Up Study

Introducton: The impact of social environment on the frequency and prevalence of schizophrenia is well known. However, in schizophrenia and other psychotic disorders, there are few studies which investigate the effect of social environment on disease prognosis and relapse. The aim of this study was to investigate the effect of neighborhood social capital level and address change on relapse in schizophrenia and similar psychotic disorders. Methods: The research sample consisted of 147 patients (schizophrenia, 76.1%; n=112), who were being followed up at regular intervals of at most six months at the Psychotic Disorders Unit outpatient clinic. Patients were followed-up for relapse indicators between January 1, 2009 and December 31, 2013. During the follow-up, relapse criteria including hospitalization, increased need for help, self-harm, suicidal thoughts, violent behavior, suicide attempts, antipsychotic dose increase and electroconvulsive therapy were used. At least one of these criteria was accepted as a relapse for that period. Neighborhood social capital levels were obtained from a general public survey conducted in Izmir city center in 2008 and the voting rates in the neighborhood during the follow-up period. In addition, during the follow-up period, any change in the address of the patient was recorded. Results: While there was no correlation between the neighborhood social environment and relapse, a significant relationship was found between relapse and address changes. The probability of relapse was 1.3 times higher in patients with change of address (95% CI: 1.0–1.6; p<0.05), and decreased likelihood of relapse was found as the duration of residence in the same neighborhood shortened ( β : (-0.05) 95% CI: [(-0.10)-(-0.003)]; p<0.05). Conclusion: In schizophrenia, relapse appears to be related with the narrow social environment (family, home address) in which the person lives, not with the wider social environment (social capital of the neighborhood). The need for adaptation to a new social environment that arises with a change of address, albeit narrowly, can lead to an increase in symptoms of schizophrenia as a psychosocial stressor. ABSTRACT BB. Association of Wider Social Environment with Relapse in Schizophrenia: Registry Based Six- Study.
High-pressure and high-temperature stability and equation of state of superhydrous phase B

We have determined the stability and P-V-T equation of state of superhydrous phase B, Mg 10 Si 3 O 18 H 4 (hereafter referred to as Shy-B) by in situ X-ray diffraction measurements at SPring-8 at pressure between 13 and 23 GPa and temperatures up to 1400°C. High temperature X-ray diffraction measurements using a conventional X-ray source were also conducted to determine the thermal expansion coefficient at atmospheric pressure. Shy-B was found to melt incongruently into assemblies of wadsleyite (β) + liquid, or ringwoodite (γ) + liquid, depending on pressure at temperatures of 1000-1250°C. The isothermal bulk modulus (K T0 ) and temperature derivative (dK/dT) of Shy-B are 132(1) GPa and -2.5(1)×10 -2 GPa/K, respectively, when we adopted an equation of state of Au proposed by Anderson et al. [1989] and also assumed its pressure derivative is 5.8 proposed by Crichton et al. [1999], while the thermal expansion coefficient (α 0 ) is 37.6(1)×10 -6 K -1 . Phase relations imply that Shy-B may be stable in relatively low temperature regions of the mantle transition zone, such as within older subducted slabs, but not in the surrounding mantle. The density difference between model subducted hydrous slabs and the surrounding mantle was calculated at 20 GPa as functions of water content and temperature in the slab using the present results, which demonstrates that the Shy-B bearing slabs with H 2 O contents of 0.5 wt%, 1.0 wt % and 1.5 wt% are denser than the surrounding mantle at temperatures below 1200°C, 900°C and 600°C, respectively. This implies that the possible penetration of a hydrous slab into the deeper mantle depends critically on the water content and temperature profile of the slab.
Compressive and tensile failure of inclined well bores and determination of in situ stress and rock strength

In this paper we investigate the occurrence of compressive and tensile failures of arbitrarily inclined well bores under a wide variety of stress conditions. The principal assumptions in this analysis are that the rock is isotropic and that it deforms elastically to the point of failure. As has been shown by previous investigators, for a given stress state and well bore orientation, it is straightforward to predict the orientation of the failures around the well bore as well as whether failure is likely to occur depending on such parameters as rock strength and borehole fluid pressure. However, as the stress state is almost never known in situ, we demonstrate how observations of compressive and tensile wall failures in inclined holes can be used to constrain in situ stress orientations and magnitudes if there are independent data on the magnitude of the least principal stress from either leak-off or microfrac tests and on the formation pore pressure. We further demonstrate how once the stress state is determined, it is possible to assess both an upper bound on the effective in situ rock strength and the degree to which increasing the borehole fluid pressure (or mud weight) can reduce the likelihood of borehole failure. Through application of this methodology to an inclined well bore in an area of complex faulting in the Gulf of Mexico, we illustrate how it is possible to utilize observations of borehole failures to determine the magnitude and orientation of the stress tensor in areas such as offshore sedimentary basins where drilling inclined well bores is quite common.
Deformation in the late Permian Boulby Halite (EZ3Na) in Teesside, NE England

Abstract Differential (mainly lateral) movement of up to a few hundred metres is interpreted from borehole data to have taken place in the late Permian Boulby Halite in Teesside, northeast England, probably when it was buried to a depth of 2000 m or more. This interpretation is based on a marked variation in the present thickness of the formation, which is thought to have been almost uniformly thick when formed, together with evidence from more than 20 borehole cores of contortion, fracturing, flow-lineation and flow-brecciation; evidence of bedding-plane slip was noted in one core. Inferred boudinage in the lower part of the formation is interpreted as evidence of local extension. Unusually for rock-salt, faults cut halite in eight of the cores, and voids in fractures and faults were noted in halite in six cores.
Antihypertensive treatment with calcium channel blockers and renal protection: focus on lercanidipine and lercanidipine/enalapril.

OBJECTIVE The aim of the study was to review the literature on clinical pharmacology of lercanidipine and experimental and clinical evidence and evaluate its ability to reduce proteinuria and preserve renal function when used as monotherapy or in combination with the angiotensin-converting enzyme (ACE) inhibitor enalapril. MATERIALS AND METHODS MEDLINE/PubMed was searched for appropriate keywords. RESULTS Lercanidipine, a third-generation calcium channel blocker, has been shown to have a unique pharmacological and clinical profile, which translates into favorable renal hemodynamic changes. The fixed-dose combination lercanidipine/enalapril has been proposed to overcome unmet therapeutic needs, often as the initial treatment in the high-risk patient. CONCLUSIONS Lercanidipine may be regarded as an ideal antihypertensive drug for patients at renal risk and possibly the preferred choice among calcium channel blocker drugs.
The neuronal transporter gene SLC6A15 confers risk to major depression

Martin A. Kohli,1,16,* Susanne Lucae,1,16 Philipp G. Saemann,1 Mathias V. Schmidt,1 Ayse Demirkan,2 Karin Hek,2 Darina Czamara,1 Michael Alexander,3 Daria Salyakina,1 Stephan Ripke,1 David Hoehn,1 Michael Specht,1 Andreas Menke,1 Johannes Hennings,1 Angela Heck,1 Christiane Wolf,1 Marcus Ising,1 Stefan Schreiber,4 Michael Czisch,1 Marianne B. Muller,1 Manfred Uhr,1 Thomas Bettecken,1 Albert Becker,5 Johannes Schramm,6 Marcella Rietschel,7 Wolfgang Maier,8 Bekh Bradley,9,10 Kerry J. Ressler,9,11,12 Markus M. Nothen,13 Sven Cichon,3,14 Ian W. Craig,15 Gerome Breen,15 Cathryn M. Lewis,15 Albert Hofman,2 Henning Tiemeier,2 Cornelia M. van Duijn,2 Florian Holsboer,1 Bertram Muller-Myhsok,1,17 and Elisabeth B. Binder1,9,17,* 1Max Planck Institute of Psychiatry, D-80804 Munich, Germany 2Erasmus University Medical Center, Department of Epidemiology, 300 CA Rotterdam, The Netherlands 3Institute of Human Genetics, Department of Genomics, Life & Brain Center, University of Bonn, D-53127 Bonn, Germany 4Christian-Albrechts University, Department of General Internal Medicine, D-24105 Kiel, Germany 5Institute for Neuropathology, University Clinics Bonn, D-53127 Bonn, Germany 6Department of Neurosurgery, University Clinics Bonn, D-53127 Bonn, Germany 7Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, University of Heidelberg, D-68159 Mannheim, Germany 8Department of Psychiatry, University of Bonn, D-53105 Bonn, Germany 9Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA 10Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA 11Yerkes National Primate Research Center, Atlanta, GA 30329, USA 12Atlanta VA Medical Center, Atlanta, GA 30033, USA 13Institute of Human Genetics, University of Bonn, D-53115 Bonn, Germany 14Institute of Neurosciences and Medicine (INM-1), Research Center Juelich, D-52425 Juelich, Germany 15Institute of Psychiatry, King’s College London, SE5 8AF London, UK 16These authors contributed equally to this work 17These authors contributed equally to this work *Correspondence: mkohli@med.miami. edu (M.A.K.), binder@mpipsykl.mpg. de (E.B.B.) DOI 10.1016/j.neuron. 2011.04. 005
Relationship between winter/spring snowfall and summer precipitation in the northern Great Plains of North America.

Abstract On the basis of snowfall observations from 1929 to 1999, positive (negative) snowfall anomalies are associated with wetter (drier) than normal conditions during the summer [July–August (JJA)] in the northern Great Plains. The five driest summers are associated with negative snowfall anomalies during the preceding winter (−66.7 mm) and spring (−62.4 mm) that cover most of the study region (∼85%). Snowfall anomalies during the late spring (April–May) are more important for determining summer moisture conditions than snowfall anomalies in fall [September–November (SON)] or winter [December–February (DJF)]. The link between snowfall anomalies and summer moisture conditions appears to be, at least partly, through soil moisture since positive (negative) snowfall anomalies are associated with wetter (drier) soils, a later (earlier) date of snowmelt, cooler (warmer) air temperatures, and more (less) evaporation during spring and summer. However, the relationship between spring snowfall and summer moistur.
New insights into the origin and distribution of the DUPAL isotope anomaly in the Indian Ocean mantle from MORB of the Southwest Indian Ridge

We report new Sr, Nd, and Pb isotope data for Mid‐Ocean Ridge Basalts (MORB) dredged between 35 and 69°E along a ∼4100 km section of the Southwest Indian Ridge (SWIR), which is one of the slowest spreading ridges of the global mid‐ocean ridge system (full rate of 16 mm yr−1). The SWIR appears isotopically more heterogeneous than other mid‐ocean ridges over similar length scales and comparable sampling density. Isotopic variations are generally independent of ridge segmentation, and the degree of heterogeneity decreases from west to east. This decrease in heterogeneity correlates with the observed increase in axial depth and decrease in crustal thickness, commonly attributed to decreasing mantle potential temperature. Data for the easternmost SWIR in the vicinity of the Indian Triple Junction confirm that these lavas are isotopically distinct from those of the Triple Junction, the Southeast Indian Ridge, and the Central Indian Ridge, reflecting the presence of an isotopic boundary over an along‐axis distance of less than 78 km. Results for lavas from the 39–41°E section extend the isotopic range of MORB to the lowest 206Pb/204Pb values (to 16.58) yet found among oceanic islands and spreading centers worldwide and confirm their extremely anomalously high 87Sr/86Sr, 207Pb/204Pb, and 208Pb/204Pb and low 143Nd/144Nd. This extreme Indian signature does not bear any isotopic affinities with recent products of the nearby Marion hot spot. Furthermore, the presence of old subducted marine sediment as a source for the low 206Pb/204Pb component is excluded, as no sediment group has the appropriate parent‐daughter Th/Pb and U/Pb characteristics to yield such compositions, not even when dewatering subduction processes are considered. Incorporation of old subduction‐modified mantle into the MORB source does not yield high enough 207Pb/204Pb and 208Pb/204Pb to explain the features of lavas from the 39–41°E section. The unusual isotopic attributes of this section (low 206Pb/204Pb and 143Nd/144Nd and high 87Sr/86Sr, 207Pb/204Pb, and 208Pb/204Pb) are best explained by the presence of stranded lower continental crust embedded in the upper mantle. This component is also inferred to be present in MORB from other spreading centers in the Indian Ocean.
Dry feet in the polder? Improving flood-risk perception of 15-year-old students in the Netherlands

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RECONSTRUCTIVE SURGERY Immediate Reconstruction After Colorectal Cancer Resection A Cohort Analysis Through the National Surgical Quality Improvement Program and Outcomes Review

Background: Colorectal cancer is one of the most common and fatal malignancies in the United States. When localized to the distal gastrointestinal tract, surgical therapy includes abdominoperineal resection (APR) or pelvic exenteration (PEX). Subsequent ablative defects are considerable, impart concerning morbidity, and often necessitate autologous reconstruction. The aim of this study was to assess postoperative outcomes after reconstruction of APR and PEX defects. Methods: The American College of Surgeons National Surgical Quality Improvement Program (2005–2017) was queried for patients undergoing APR for lower gastrointestinal malignancies with concurrent autologous reconstructions. Cases of disseminated cancer were excluded. Postoperative adverse event profiles, including rates of wound and systemic complications, were evaluated. Multivariate regression analysis controlling for age, sex, body mass index, and operative time was performed to calculate adjusted odds ratios (ORs). Results: A total of 1309 patients were identified as undergoing APR/PEX with concomitant reconstruction. The majority (96.9%) of reconstructions consisted of muscle, myocutaneous, fasciocutaneous, or omental pedicled flaps. Of the cohort, 45.7% experienced at least 1 all-cause complication within 30-days of the procedure. Having a limited or moderate frailty (frailty index of “1” or “2”) was identified as a predictor of all-cause complications [OR, 1.556; 95% confidence interval (CI), 1.187–2.040, P = 0.001; and OR, 1.741; 95% CI, 1.193–2.541, P = 0.004, respectively], whereas smoking was a predictor of wound complications (OR, 1.462; 95% CI, 1.070–1.996, P = 0.017) and steroid use was a predictor of mild systemic complications (OR, 2.006; 95% CI, 1.058–3.805, P = 0.033). Conclusion: Anorectal cancer resection often necessitates reconstruction secondary to postexenteration perineal defects. The incidence of postoperative complications is relatively high, and several risk factors are identified to help refine patient optimization.
Secular temperature changes in Hawai‘i

While the upward trend in global mean temperature has been intensively studied, some regional temperature trends are less well known. We document secular temperature changes in the Hawaiian Islands for the past ∼85 years based on an index of 21 stations. Results show a relatively rapid rise in surface temperature in the last ∼30 years, with stronger warming at the higher elevations. The bulk of the increase in mean temperature is related to a much larger increase in minimum temperatures compared to the maximum—a net warming about 3 times as large—resulting in a reduction of the diurnal range. For much of the period of record analyzed here, surface temperature in Hawai‘i has varied coherently with changes in the Pacific Decadal Oscillation (PDO). However, in recent decades, the secular warming has begun to predominate, such that despite the recent cooling associated with the PDO, surface temperatures in Hawai‘i have remained elevated. The greater warming trend at the higher elevations may have significant ecological impacts.
Högbomite Associated with Vanadium bearing Titaniferous Magnetite of Mafic-Ultramafic Suite of Moulabhanj Igneous Complex, Orissa, India

Hogbomite associated with vanadium bearing titaniferous magnetite has been identified in mafic-ultramafic suite of rocks of Moulabhanj, Orissa, India. The igneous complex intruded into granulite terrain of Eastern Ghat Super Group. The iron mineral assemblages are Ti-V magnetite, martite and ilmenite. Hogbomite occurs in association with Ti-V magnetite and exhibits both primary and secondary micro-textures. EPMA study confirms the presence of hogbomite.
Spatio-Temporal Convolutional LSTMs for Tumor Growth Prediction by Learning 4D Longitudinal Patient Data

Prognostic tumor growth modeling via volumetric medical imaging observations can potentially lead to better outcomes of tumor treatment management and surgical planning. Recent advances of convolutional networks (ConvNets) have demonstrated higher accuracy than traditional mathematical models can be achieved in predicting future tumor volumes. This indicates that deep learning based data-driven techniques may have great potentials on addressing such problem. However, current 2D image patch based modeling approaches can not make full use of the spatio-temporal imaging context of the tumor’s longitudinal 4D (3D + time) patient data. Moreover, they are incapable to predict clinically-relevant tumor properties, other than the tumor volumes. In this paper, we exploit to formulate the tumor growth process through convolutional Long Short-Term Memory (ConvLSTM) that extract tumor’s static imaging appearances and simultaneously capture its temporal dynamic changes within a single network. We extend ConvLSTM into the spatio-temporal domain (ST-ConvLSTM) by jointly learning the inter-slice 3D contexts and the longitudinal or temporal dynamics from multiple patient studies. Our approach can incorporate other non-imaging patient information in an end-to-end trainable manner. Experiments are conducted on the largest 4D longitudinal tumor dataset of 33 patients to date. Results validate that the proposed ST-ConvLSTM model produces a Dice score of 83.2%±5.1% and a RVD of 11.2%±10.8%, both statistically significantly outperforming (p < 0.05) other compared methods of traditional linear model, ConvLSTM, and generative adversarial network (GAN) under the metric of predicting future tumor volumes. Additionally, our new method enables the prediction of both cell density and CT intensity numbers. Last, we demonstrate the generalizability of ST-ConvLSTM by employing it in 4D medical image segmentation task, which achieves an averaged Dice score of 86.3%±1.2% for left-ventricle segmentation in 4D ultrasound with 3 seconds per patient case.
Cooling of the Atlantic by Saharan dust

Using aerosol optical depth, sea surface temperature, top‐of‐the‐atmosphere solar radiation flux, and oceanic mixed‐layer depth from diverse data sources that include NASA satellites, NCEP reanalysis, in situ observations, as well as long‐term dust records from Barbados, we examine the possible relationships between Saharan dust and Atlantic sea surface temperature. Results show that the estimated anomalous cooling pattern of the Atlantic during June 2006 relative to June 2005 due to attenuation of surface solar radiation by Saharan dust remarkably resemble observations, accounting for approximately 30–40% of the observed change in sea surface temperature. Historical data analysis show that there is a robust negative correlation between atmospheric dust loading and Atlantic SST consistent with the notion that increased (decreased) Saharan dust is associated with cooling (warming) of the Atlantic during the early hurricane season (July–August–September).
Prevalence of malaria and quantification of cytokine levels during infection in East Nile locality, Khartoum State: a

The cytokines interferon gamma (IFN-γ), interleukin-10 Background: (IL-10) and tumor necrosis factor-α (TNFα) play an important role in malaria infection. The aim of this study was to determine the prevalence of malaria and to evaluate cytokine responses to malaria infection in patients from the East Nile locality of Khartoum State. This study was carried out from May to July 2018 in the East Nile Methods: Locality, Khartoum State. Blood samples were collected from 384 randomly selected patients for blood film analysis. Of these, 39 were selected for cytokine level analysis (10 control and 29 patient samples), determined using enzyme-linked immunosorbent assays. The malaria prevalence rate among 384 patients was 18.5%. Results: was the most prevalent (13%), while the Plasmodium falciparum prevalence of was 4.6%. The rate of mixed infection was Plasmodium vivax 0.8%. There was a higher prevalence rate (22.7%) in males than females (15.6%). However, we found no significant correlation between cytokine levels and parasitemia in the study group. Nevertheless, our study demonstrated a significant correlation between cytokine levels and recurrent infections. Together, our data show that malaria remains a public health Conclusions: problem in East Nile locality with a high prevalence. Additionally, cytokine levels were found to be correlated with recurrent malaria infection.
Electrical impedance variation with water saturation in rock

We measured the electrical impedances of 22 sandstone samples during oil‐driving‐water tests using the two‐electrode method. Experiments show that the imaginary part X of the impedance (R + iX) of rock may respond well to water saturation in the frequency range 100 Hz–15 MHz. We found that the maximum −X values and their corresponding interfacial polarization frequencies are linear with water saturation. The lower critical frequency is found to vary with water saturation, in an unclear relationship with the characteristic length of rock. The dissipation factor at the interfacial polarization frequency remains quite stable and may be an indicator of the pore structure of rock. We used an equivalent circuit to explain the dispersive behavior of rock. More than one interfacial polarization frequency in the impedance Argand plot is predicted and can be observed if the measurement frequency range is wide enough.
Metal-contaminated soils : In situ inactivation and phytorestoration

Extent and nature of the metal contaminant problem physico-chemical aspects of metal immobilization biological interactions role of soil microbes role of non-woody and woody plants role of plant-microbe interactions fauna considerations human health considerations field implementation and case studies practical considerations site characterization treatment selection relative to contaminant profile logistics of application, incorporation, planting monitoring risk assessment factors persistence of immobilization legislative aspects.