Miracle-dz/UniFAR-FTUs huggingface dataset:
The Clinical, Diagnostic, and Therapeutic Characteristics of 22 Male Patients with Breast Cancer.

Aim: The aim of this study is to evaluate the clinicopathological, diagnostic, and therapeutic features of male breast cancer. Study Design: therapy was given to 17 (77.2%) patients with receptor positivity. Median follow-up time of the patients was 31.2 months, and 3 recurrences was observed. Conclusion: The incidence of male breast cancer has been increased in the recent years. Since the management of male breast cancer is still based on the rules of female breast cancer, large scale clinical studies are urgently needed to develop an international guideline for of this rare cancer.
Insights into population genetics, connectivity and demographic history of the longnosed skate
 Dipturus oxyrinchus
 (Linnaeus, 1758) in the western Mediterranean Sea

Genetic information is crucial for the conservation of Dipturus oxyrinchus (Linnaeus, 1758), a threatened large skate with declining populations over most of its geographical range. The main aim of the present study was to investigate the genetic structure, connectivity and demographic history of the longnosed skate in Sardinia (western Mediterranean Sea). Patterns of population structure were assessed in 175 specimens from six sampling sites. Variation in two mitochondrial genes (cytochrome c oxidase subunit I (COI) and control region) highlighted high genetic diversity and low but significant genetic differentiation among sites, which clustered into three groups corresponding to the north‐west, north‐east and south Sardinian coasts. The observed genetic structuring could presumably depend on a combination of past geological events, contemporary restrictions to dispersal and biological characteristics of the species (e.g. site‐fidelity, no pelagic larval stage, limited dispersal of juveniles and/or adults). Demographic analyses showed signs of past population expansion, but substantial current stability of Sardinian populations. From a conservation perspective, these results are encouraging, and indicate that Sardinian populations are still large and stable, and seem not to have suffered negative side‐effects from the ever‐growing fishing pressure in the region. The occurrence of genetic structuring strongly supported the close monitoring of populations to identify any erosion of their gene pool, and high genetic variability of the Sardinian D. oxyrinchus populations could thus represent priority populations for conservation purposes, providing potential sources for recolonization in cases of local extinctions in other areas of the distribution range of the species. When the sequences from Sardinia were compared with those available from other areas, the data seem to exclude the possibility that the Atlantic and Mediterranean host totally isolated populations or even different species, as recently suggested. However, additional markers and a larger sampling sites are needed to confirm these findings.
p-адические L-функции и p-адические кратные дзета значения

Статья посвящена памяти Георгия Вороного. Описываются новые избранные результаты о рядах Эйзенштейна, о (мотивных), (p-адических), (кратных) значениях (круговых) дзета и L-функций, и их приложения, полученные ниже перечисляемыми авторами, а также элементарное введение в эти результаты. Дан краткий обзор новых результатов о (мотивных), (p-адических), (кратных) значениях (круговых) дзета функциях, L-функциях и рядах Эйзенштейна. Статья ориентирована на избранные задачи и не является исчерпывающей. Начало статьи содержит краткое изложение результатов о числах Бернулли, связанных с исследованиями Георгия Вороного. Результаты о кратных значениях дзета функций были представлены Д. Загиром, П. Делинем и А. Гончаровым, А. Гончаровым, Ф. Брауном, К. Глэносом (Glanois) и другими. С. Унвер ("Unver) исследовал кратные p-адические дзета-значения глубины два. Таннакиева интерпретация кратных p-адических дзета-значений дана Х. Фурушо. Краткая история и связи между группами Галуа, фундаментальными группами, мотивами и арифметическими функциями представлены в докладе Ю. Ихара. Результаты о кратных дзета-значениях, группах Галуа и геометрии модулярных многообразий представлены Гончаровым. Интересная унипотентная мотивная фундаментальная группа определена и исследована Делинем и Гончаровым. В данной работе мы кратко упоминаем в рамках (p-адических) L-функций и (p-адических) (кратных) дзета-значений применения подходов Куботы-Леопольдта и Ивасавы, которые основанны на p-адических L-функциях Куботы-Леопольда, и арифметических p-адических L-функциях Ивасавы. Прореферирован ряд недавних работ (и соответствующих результатов): кратные дзета-значения в корнях из единицы, построение семейств мотивных итерированных интегралов с предписанными свойствами по Глэносу (Glanois); явные выражения для круговых p-адических кратных дзета-значений глубины два по Унверу (Unver); связи арифметических степеней циклов Кудлы-Рапопорта на интегральной модели многообразия Шимуры, соответствующей унитарной группе сигнатуры (1,1), с коэффициентами Фурье центральных производных рядов Эйзенштейна рода 2 по Санкарану (Sankaran). Более полно с содержанием статьи можно ознакомиться по приводимому ниже оглавлению: Введение. 1. Сравнения типа Вороного для чисел Бернулли. 2. Римановы дзета-значения. 3. О группах классов колец с теорией дивизоров. Мнимые квадратичные и круговые поля. 4. Ряды Эйзенштейна. 5. Группы классов, поля классов и дзета-функции. 6. Кратные дзета-значения. 7. Элементы неархимедовых локальных полей и неархимедова анализа. 8. Итерированные интегралы и (кратные) дзета-значения. 9. Формальные и p-делимые группы. 10. Мотивы и (p-адические) (кратные) дзета-значения. 11. О рядах Эйзенштейна, ассоциированных с многообразиями Шимуры. Разделы 1-9 и подраздел 11.1 (О некоторых многообразиях Шимуры и модулярных формах Зигеля) можно рассматривать как элементарное введение в результаты раздела 10 и подраздела 11.2 (О несобственном пересечении дивизоров Кудлы-Рапопорта и рядах Эйзенштейна). Я глубоко признателен Н. М. Добровольскому за помощь и поддержку в процессе подготовки статьи к печати.
The Forward‐Looking Ability of the Real Exchange Rate and its Misalignment to Forecast the Economic Performance and the Stock Market Return

This paper aims to examine whether exchange rates can predict future changes in the stock market return and in the economic performance of a country. On the basis of a revision that incorporates relative stock price and rational expectation in Dornbusch's dynamic Mundell&#8211;Fleming model, I present a model that can be used for analysing the forward&#8208;looking ability of the real exchange rate. The model builds on the works of Campbell and Shiller (Journal of Political Economy, 95, 1987 and 1062), MacDonald and Taylor (IMF Staff Papers, 40, 1993 and 89) and Engel (American Economic Review, 106, 2016 and 436) which can also be converted into a forward&#8208;looking version of real exchange rate misalignment model to investigate whether the deviation of the real exchange rate from its fundamental value would contain an economically significant predictable component on forecasting the future stock price movement and the real output.
A Clinical Study of Androgenetic Alopecia (III)

type of alopecia after puberty, is characterized by progressing change of hairs into fine vellus form on the frontal and parietal scalp progressively, shortening in length and miniaturization of both the papillae and matrices, as well as the resulting hair shaft1. In our department, Han et al2 and Lim et al3, already reported the clinical aspects of androgenetic alopecia. Hence this report is in the continuation of the previous study and consecutive analysis of clinical aspects of A Clinical Study of Androgenetic Alopecia(III)
Interrater Reliability and Concurrent Validity of the Neonatal Eating Outcome Assessment.

IMPORTANCE Few neonatal feeding assessments are currently available, and the Neonatal Eating Outcome Assessment is the only one that identifies feeding impairment while considering the developmental changes that occur from preterm birth to term-equivalent age. OBJECTIVE To determine the interrater reliability and concurrent validity of the Neonatal Eating Outcome Assessment. DESIGN Prospective, observational study. SETTING Level 4 neonatal intensive care unit. PARTICIPANTS A convenience sample of 7 neonatal therapists participated in reliability testing. For concurrent validity, a prospective cohort of 52 preterm infants born ≤32 wk gestation had feeding assessed at term-equivalent age. OUTCOMES AND MEASURES Intraclass correlations (ICCs) and Fleiss's κ statistics were used to define reliability across therapists, who independently scored five videos of preterm infants orally feeding using the Neonatal Eating Outcome Assessment. Concurrent validity was determined by evaluating relationships between the Neonatal Oral Motor Assessment Scale (NOMAS) and the Neonatal Eating Outcome Assessment using an independent-samples t test and χ² analysis. RESULTS The ICC for the Neonatal Eating Outcome Assessment total score was 0.90 (confidence interval [CI] [0.70, 0.99]). Fleiss's κ scores for the 19 scorable items on the Neonatal Eating Outcome Assessment had predominately moderate, fair, and slight agreement, with 3 items having poor agreement. Dysfunctional NOMAS scores were related to lower Neonatal Eating Outcome Assessment scores (t[49.4] = 3.72, mean difference = 12.2, 95% CI [5.60, 18.75], p = .001). CONCLUSIONS AND RELEVANCE The Neonatal Eating Outcome Assessment has excellent reliability. Concurrent validity was established. WHAT THIS ARTICLE ADDS This article reports that the final version of the Neonatal Eating Outcome Assessment (Version 5.7) has excellent interrater and concurrent validity and is an important tool to assess the occupation of infant feeding in clinical practice.
A study on language anxiety among the ESL a study on language anxiety among the ESL undergraduates at the South Eastern University of Sri Lanka

In the process of learning English as a second language some emotional factors influence learning abilities. The emotional factors are mainly thought to be intelligence, motivation, attitudes and anxiety. Among them, anxiety stands out as one of the most influential factors in learning the English language. It can impede students’ learning process and achievements. Previous research unearthed many reasons for the existence of anxiety among ESL learners. The present study aimed to investigate the anxiety experienced by the ESL students of the South Eastern University of Sri Lanka (SEUSL), identify the factors that led to anxiety and the strategies to overcome it. Mixed methods approach was used covering questionnaire survey, interview and focus group discussion. The participants of the study included 50 undergraduates of SEUSL who learned English as a second language. The data were analyzed manually and using Statistical Package for Social Sciences (SPSS). Results of the present study suggest that majority of the students experience some kind of anxiety in the ESL classes and most of the students face a form of anxiety predominantly during oral tests and in-class presentations. Furthermore, this study suggests measures to rectify the situations; both students and instructors need to carefully deal with the situations that provoke anxiety. In addition, providing a comfortable, friendly learning environment for the ESL undergraduates at the SEUSL is helpful to ease anxiety.
A Global Survey of Apparent Aerosol‐Cloud Interaction Signals

We update and expand analysis of the apparent responses to aerosol variations of the planet's cloud regimes seen by the Moderate Resolution Imaging Spectroradiometer (MODIS). We distinguish between morning aerosol loadings and afternoon clouds and consider local scales explicitly. Aerosol loading is represented by gridded aerosol optical depth (AOD) from either MODIS or a reanalysis data set, while cloud information comes exclusively from MODIS. The afternoon cloud affected quantities (CAQs) examined in conjunction with morning AOD include precipitation and cloud radiative effect, in addition to cloud properties. One analysis thrust focuses on calculating global means distinguished by morning cloud regime, of afternoon CAQs, for distinct percentiles of grid cell seasonal morning AOD distributions. When the dependence of these global means on AOD is examined, we find persistent increases in cloud radiative fluxes with AOD as predicted by classic aerosol‐cloud interaction paradigms, and also deviations from expected cloud responses, especially for precipitation. The other analysis thrust involves calculations at 1° scales of logarithmic CAQ sensitivities to AOD perturbations, approximated by linear regression slopes for distinct morning cloud regime groups. While the calculations are fundamentally local, we concentrate on the prevailing sensitivity signs in statistics of the slopes at global scales. Results from this second analysis approach indicate CAQ directions of change with AOD that are largely consistent with the first approach. When using a rather simple methodology where meteorological variables are treated as if they were CAQs, no conclusive results on the potential influence of meteorology on our findings are inferred.
On the spillover effect and optimal size of marine reserves

Marine reserves are an essential component of model fisheries management. As implementing marine reserves induces an inherent tradeoff between the harvesting and conservation, to solidify the insight into fisheries management with marine reserves is fundamental for management success. Finding an optimal reserve size that improves the fishing yield is not only theoretical interest but also practically important to assess the underlying tradeoffs and to facilitate decision making. Also, since the species migration determines the degree of the spillover effect from a marine reserve, it is a key consideration to explore the performance of marine reserve. Here, we investigate an optimal reserve fraction and its management outcome under various spillover strength via a simple two-patch mathematical model, in which one patch is open to fishing, and the other is protected from fishing activities. The two-patch model is approximated by a single population dynamics when the migration rate is sufficiently larger than the growth rate of a target species. In this limit, it is shown that an optimal reserve size exists when the pre-reserve fishing is operated at the fishing mortality larger than the fMSY, the fishing mortality at the maximum sustainable yield (MSY). Also, the fishing yield with the optimal reserve size becomes as large as MSY in the limit. Numerical simulations across various migration rates between two patches suggest that the maximum harvest under the management with a marine reserve is achieved in this limit, and this contrasts with the conservation benefit in which is maximized at the intermediate migration rate.
Contribution of a parasitoid species to multiplication and transmission of a multiple nucleopolyhedrovirus in caterpillars

Spodoptera exigua multiple nucleopolyhedrovirus (SeMNPV) and Microplitis pallidipes are both used as biocontrol agents of the beet armyworm (Spodoptera exigua). However, it has not been determined how beet armyworms respond when these agents interact. Here, we studied the effects of M. pallidipes on virus multiplication and transmission using quantitative detection of SeMNPV. Our results indicated that parasitoids promoted virus multiplication in caterpillars (105 copies per caterpillar) and that it was more advantageous when the M. pallidipes oviposited one day prior to infection with NPV. Interestingly, SeMNPV was transmitted by M. pallidipes in four ways. Transmission efficiency was higher for parasitoids whose body surfaces were contaminated with NPV, and for parasitoids ovipositing on NPV‐infected caterpillars, than for those emerging from NPV‐infected caterpillars, or feeding on mixtures of honey, water and NPV. Our study reveals that parasitoids do affect the proliferation and transmission of NPV in caterpillars and suggests that M. pallidipes could be used to strengthen the effectiveness of SeMNPV as a biocontrol agent.
Knowledge and practice of Caregivers about Prevention of Early Childhood Caries

Aim: This study was conducted to assess level of knowledge and practice of caregivers regarding prevention of early childhood caries in preschool children. Methods: A cross-sectional study was conducted among caregivers of preschool children. A consecutive sampling technique was used to recruit 399 caregivers based on sample size calculation. Data was collected based on clinical examination and previously validated questionnaires. Dental caries experiences were calculated by dmft index using WHO criteria for dental caries diagnosis. Statistical analysis: Data was statistically analyzed using the Statistical Package of Social Science Software program, version 23. Data presented using frequency and percentage for qualitative variables. Comparison between groups had been performed using Chi-square or Fisher’s exact test for qualitative variables. PValues less than 0.05 were considered statistically significant. Results: This study highlights that caregivers who have good knowledge about oral health are mothers, high level of education, high family income, caregivers of child with dmft < 7. Additionally, family with high income, caregivers of children aged < 4 years and caregivers of the children with dmft < 7 and caregivers with sufficient knowledge each has higher practice regarding children oral health Conclusion: the majority of caregivers (64.4 %.) had sufficient knowledge related to prevention of ECC. In spite of that most of them (63.2% ) were having low skills to prevent ECC . So, oral health education programs should be targeted to caregivers especially the lower socio-economic groups to motivate them to take care of their child oral health and improve their practice.
The knowledge and the attitude of youth couples on/towards consanguineous marriages in the north of Iran

Aim: Consanguinity is an important risk factor in genetic diseases and in congenital malformations. This study was done to assess the knowledge and the attitude of youth couples on/towards consanguineous marriages in the north of Iran. Material and Methods: This descriptive-analytic study was carried out on 250 young people (125 couples) in Northern Iran during the year 2008. The information was obtained by a direct interview and the questionnaire included four sections which comprised of 39 closed questions. The data was analyzed by using SPSS, version 11.5 and the Chi-Square test. Results: Consanguineous marriages were observed in 32.5% of the couples. Consanguineous marriages were determined in 20.87% and 11.63% of the rural and the urban residents respectively. The knowledge of the youth was poor (49.2% of the females and 40% of the males) on the genetic consequences of inbreeding. The results on the attitude of youths showed that 38.8% of the subjects had agreed and that 61.2% of them had disagreed on consanguineous marriages. There was a significant association between the knowledge of the youths and their attitudes towards consanguineous marriages with their ethnicity, education and residency (p<0.05). Conclusions: This study showed that the knowledge of the youth couples towards consanguineous marriages was poor. Health education programs are needed to improve the knowledge of the youth couples on consanguineous marriages; that they are a potential risk factor in congenital malformations and in genetic diseases in the offspring.
Absence of Wharton’s jelly: an association with feto-maternal morbidity

• 1 case in 1961 by Bergman et al in which a segment of the umbilical arteries were devoid of their Wharton’s jelly covering. • 2, 3 and 4 cases were reported by Labarrere et al described 3 cases of completely absent Wharton’s jelly around the umbilical cord arteries but was present around the umbilical veins; all cases were of meconium stained term neonates who died shortly after birth in whom umbilical arteries were detached from the cord substance and were associated with acute fetal distress and perinatal death which may be due to compression of the unprotected vessels. • 5 case reported by Thomson and Hoo. • 6 case by Kulkarni et al. • 7 case by Christiano et al.
RADX Sustains POT1 Function at Telomeres to Counteract RAD51 Binding, which Triggers Telomere Fragility

The 3’ terminal DNA extensions at chromosome ends can become engaged into multiple biochemical reactions during DNA replication, telomerase-mediated telomere extension, homology directed DNA repair, nucleolytic processing and DNA damage checkpoint activation. To keep these activities in check, telomeric 3’ overhangs can be hidden in t-loop structures or they associate with specialized proteins such as POT1. Here, we explore the telomeric microenvironment using a proximity-dependent labeling approach and identify the oligonucleotide/oligosaccharide-binding (OB)-fold containing protein RADX. RADX binds single-stranded telomeric DNA throughout the cell cycle along with POT1, suppressing accumulation of fragile telomeres, which are indicative of telomere replication defects. Telomere fragility in POT1 and RADX double-depleted cells was due to accumulation of the RAD51 recombinase at telomeres. RADX also supports DNA damage signaling at POT1-depleted telomeres counteracting RAD51 binding. Thus, RADX represents next to POT1 a second OB-fold containing single-strand telomere binding protein sustaining telomere protection.
Magnitude of Malaria Infection in Ethiopia

Background: Malaria is a major public health problem in worldwide and causes high morbidity and mortality. Studying its prevalence is necessary to implement effective control measures. Therefore, the aim of this study was to determine the prevalence of malaria in Arba Minch hospital, Ethiopia. Method: A cross sectional study was conducted from January to April, 2010. A well designed and structured questionnaire and Laboratory investigation were used to collect data. Data was processed and analyzed with SPSS version16.0. Results: A total of 400 patients clinically suspected to have malaria were examined with overall prevalence of malaria was 7% (28 malaria cases out of 400 patients) of which 18 (64.3%) were positive for Plasmodium falciparum and 7 (25%) for Plasmodium vivax; the remaining 3 (10.7%) showed mixed infections of Plasmodium falciparum and Plasmodium vivax. Males 16 (4%) were more infected than females 12 (3%). Gender had statistically significant association with malaria infection (p<0.005). All age groups were infected but high prevalence observed in age groups 15–19, followed by 20–29 years old. Conclusion: This study showed that high prevalence of malaria was observed. Therefore health professionals and administra- tors have to focus on giving health education on prevention and control of malaria.