Miracle-dz/UniFAR-FTUs huggingface dataset:
Multiscale factors control community and species distribution in mountain peatlands

We studied the vegetation of 166 fens in Yellowstone National Park, USA, to determine the relationship between species distribution in mountain peatlands and regional-, landscape-, and local-scale environmental variables. Plant communities were identified through hierarchical agglomerative cluster analysis, patterns in species distribution were explored using nonmetric multidimensional scaling, and the relative importance of variables was assessed though partial canonical correspondence analysis. Five major bedrock types influenced groundwater feeding fens: three volcanic types, a glacial till complex, and rock altered by acidic geothermal activity. Ionic concentrations generally increased with pH, but acidic geothermal fens had very low pH and high electrical conductivity. Bryophyte distribution was controlled by groundwater chemistry, while vascular plants responded to a broader range of variables. When partitioned by spatial scale, landscape variables accounted for >60% of the variation explained. When.
New insights into the effects of caffeine on adult hippocampal neurogenesis in stressed mice: Inhibition of CORT‐induced microglia activation

Chronic stress‐evoked depression has been implied to associate with the decline of adult hippocampal neurogenesis. Caffeine has been known to combat stress‐evoked depression. Herein, we aim to investigate whether the protective effect of caffeine on depression is related with improving adult hippocampus neurogenesis and explore the mechanisms. Mouse chronic water immersion restraint stress (CWIRS) model, corticosterone (CORT)‐established cell stress model, a coculture system containing CORT‐treated BV‐2 cells and hippocampal neural stem cells (NSCs) were utilized. Results showed that CWIRS caused obvious depressive‐like disorders, abnormal 5‐HT signaling, and elevated‐plasma CORT levels. Notably, microglia activation‐evoked brain inflammation and inhibited neurogenesis were also observed in the hippocampus of stressed mice. In comparison, intragastric administration of caffeine (10 and 20 mg/kg, 28 days) significantly reverted CWIRS‐induced depressive behaviors, neurogenesis recession and microglia activation in the hippocampus. Further evidences from both in vivo and in vitro mechanistic experiments demonstrated that caffeine treatment significantly suppressed microglia activation via the A2AR/MEK/ERK/NF‐κB signaling pathway. The results suggested that CORT‐induced microglia activation contributes to stress‐mediated neurogenesis recession. The antidepression effect of caffeine was associated with unlocking microglia activation‐induced neurogenesis inhibition.
Abundance, Survival, and Life History Strategies of Juvenile Chinook Salmon in the Skagit River, Washington

AbstractTo identify potential actions for conserving Chinook Salmon Oncorhynchus tshawytscha in the Skagit River, Washington, we used a 16-year time series of streamflow data, adult escapement, and out-migrant abundance to understand how out-migrant abundance and life history diversity were related to spawner abundance and incubation flows. Three freshwater rearing strategies were distinguished based on body size at out-migration: fry (≤45 mm FL), subyearling parr (46–100 mm FL), and yearling smolts (>100 mm FL). Density-independent and density-dependent processes were hypothesized to influence survival in sequence, with density-independent mechanisms operating during incubation and density-dependent mechanisms operating between emergence and out-migration. A model selection process compared spawner–recruit models with and without different incubation flow metrics. Density-independent models that included measures of flow duration and magnitude were strongly supported (Akaike's information criterion [AIC].
Die Gattung Lepidium (L.) R.Br. Eine monographische Studie

Die gattung lepidium (L.) R.Br. Eine monographische studie (Mitteilungen aus dem botanischen museum der Universitat Zurich XXVIII) , Die gattung lepidium (L.) R.Br. Eine monographische studie (Mitteilungen aus dem botanischen museum . , مرکز فناوری اطلاعات و اطلاع رسانی کشاورزی
Clearing the air: A study of cannabis-related presentations to urban Alberta emergency departments following legalization.

OBJECTIVES Non-medical cannabis recently became legal for adults in Canada. Legalization provides opportunity to investigate the public health effects of national cannabis legalization on presentations to emergency departments (EDs). Our study aimed to explore association between cannabis-related ED presentations, poison control and telemedicine calls, and cannabis legalization. METHODS Data were collected from the National Ambulatory Care Reporting System from October 1, 2013, to July 31, 2019, for 14 urban Alberta EDs, from Alberta poison control, and from HealthLink, a public telehealth service covering all of Alberta. Visitation data were obtained to compare pre- and post-legalization periods. An interrupted time-series analysis accounting for existing trends was completed, in addition to the incidence rate ratio (IRR) and relative risk calculation (to evaluate changes in co-diagnoses). RESULTS Although only 3 of every 1,000 ED visits within the time period were attributed to cannabis, the number of cannabis-related ED presentations increased post-legalization by 3.1 (range -11.5 to 12.6) visits per ED per month (IRR 1.45, 95% confidence interval [CI]; 1.39, 1.51; absolute level change: 43.5 visits per month, 95% CI; 26.5, 60.4). Cannabis-related calls to poison control also increased (IRR 1.87, 95% CI; 1.55, 2.37; absolute level change: 4.0 calls per month, 95% CI; 0.1, 7.9). Lastly, we observed increases in cannabis-related hyperemesis, unintentional ingestion, and individuals leaving the ED pre-treatment. We also observed a decrease in co-ingestant use. CONCLUSION Overall, Canadian cannabis legalization was associated with small increases in urban Alberta cannabis-related ED visits and calls to a poison control centre.
Low relative skeletal muscle mass predicts incident hypertension in Korean men: a prospective cohort study

Supplemental Digital Content is available in the text Objective: Previous cross-sectional studies suggest an association between low muscle mass and hypertension. However, whether low muscle mass predicts the development of hypertension is unknown. The aim of this study is to investigate the relationship between relative muscle mass and incident hypertension in a large prospective cohort of Korean adults. Methods: In this prospective cohort study, we analyzed 132 324 participants without hypertension at baseline who underwent two health check-ups in 2012 and 2016 or in 2013 and 2017 with a 4-year interval. The participants were divided according to skeletal muscle mass index quartiles (Q1--Q4) according to their baseline skeletal muscle mass index [skeletal muscle mass index (%) = total skeletal muscle mass (kg)/body weight (kg) × 100). Multivariate logistic regression was used to estimate the odds ratio and 95% confidence interval for the development of hypertension after 4 years. Results: After 4 years, 7180 (5.43%) participants developed hypertension. The incidence rates of hypertension were 12.11, 8.58, 6.93, and 4.37% in men and 4.02, 2.29, 1.73, and 1.18% in women in Q1, Q2, Q3, and Q4, respectively. The multivariate adjusted odds ratios (95% confidence intervals) for incident hypertension in Q1, Q2, and Q3, in comparison with Q4, were 1.46 (1.3–1.63), 1.31 (1.19–1.46), and 1.26 (1.14–1.40) in men and 0.97 (0.76–1.23), 1.12 (0.90–1.38), and 1.14 (0.92–1.42) in women, respectively. Conclusion: Low relative skeletal muscle mass was independently and significantly associated with the incidence of hypertension only in Korean men. Further research is required to understand the underlying mechanisms of this relationship.
Prevalence and predictors of suicidal thoughts and behaviours among Australian police and emergency services employees

Objective: This study presents rates of suicide thoughts and behaviours of police and emergency services personnel around Australia. In addition, it examines personal (i.e. mental health, substance use) and working environment risk and protective factors. Method: A stratified random sample of personnel from 33 Australian emergency services organisations were invited to participate in a mental health and wellbeing survey. In total, 14,868 Australian ambulance, fire and rescue, police and state emergency services employees participated and self-reported any suicidal thoughts, plans and/or attempts in the 12 months prior to the survey or at any stage in their life. Logistic regressions assessed factors associated with suicidal thoughts and behaviours. Results: Employees reported notably higher rates of suicidal thoughts and plans than the general Australian adult population, but not attempts. Male, single/divorced, non-heterosexual or longer-serving employees reported higher rates of suicidal thoughts and behaviours across each sector. Perceptions of stigma regarding mental health conditions from others in the workplace, negative impact of work on one’s private life and low meaning of work were associated with suicidal thoughts, while bullying significantly differentiated who planned and attempted suicide from those who reported suicidal thoughts only. Higher resilience and social support were associated with lower suicidal thoughts, while intermittent explosive anger and illegal drug use were associated with higher rates of suicidal thoughts. Post-traumatic stress disorder symptoms significantly differentiated who planned suicide, while misuse of prescription drugs and psychological distress differentiated who attempted suicide from those who only reported suicidal thoughts. Conclusion: Amid inherently stressful occupations, it is important that workplaces function in a way that supports their personnel. Access to mental health services should be promoted and readily available to personnel.
SUSPENSION FEEDING BY MARINE INVERTEBRATE LARVAE: CLEARANCE OF PARTICLES BY CILIATED BANDS OF A ROTIFER, PLUTEUS, AND TROCHOPHORE

1. High speed cinefilms of a serpulid trochophore, a bdelloid rotifer, and an echinopluteus show two ways cilia remove particles from suspensions.2. In the pluteus a particle passing through the band of cilia triggers a localized change of beat which appears to be a reversal and which retains the particle on the upstream side of the band of cilia. Retention of particles by an induced local reversal of beat implies that the stimulus occurs during the forward effective stroke of a cilium and that the reversed effective stroke of this cilium or its neighbors begins before the forward stroke is completed. For this system, clearance and transport of particles, rejection of particles, and swimming can be accomplished by a single band of cilia.3. In the bdelloid rotifer, and probably in the serpulid trochophore, the opposed action of parallel preoral and postoral bands of cilia apparently causes the longer preoral cilia to push particles relative to the water during the latter part of the effective stroke. This .
Genetic Diversity of Parkia biglobosa from Different Agroecological Zones of Nigeria Using RAPD Markers

Parkia biglobosa (Jacq.) is an important leguminous tree crop in the African Savannahs useful to the natives where it is found, for domestic use. Previous diversity studies on this tree crop had been majorly on morphological and biochemical analysis. In order to capture the maximum diversity not obtained by previous research, the study aimed at evaluating the genetic diversity of accessions of this crop in the different agroecological zones in Nigeria using RAPD markers. A total of 81 scorable bands with an average of 8.1 bands per primer were amplified among the accessions studied. Intrazonal genetic diversity analysis showed a percentage polymorphism with a range of 11.11% to 65.43% among the agroecological zones studied. Although, gene diversity was highest within Humid forest agroecological zone, a low genetic distance and high genetic similarity between the agroecological zones were observed. Cluster analysis indicated six main groups of which four groups had single accessions while the two groups clustered the remaining accessions, indicating a narrowed genetic base from the 23 accessions studied.
Efficacy of a vaginal tablet as a Persian medicine product on vulvovaginal candidiasis: a double-blind, randomised, placebo-controlled trial

Abstract Context In Persian medicine, topical ingredients such as Rosa damascena Mill. (Rosaceae), are usually recommended for the treatment of uterine diseases. Scientific evaluation of these historical documents can be valuable for finding new potential use in conventional medicine. Objective This clinical trial was performed to determine whether the use of the ‘ward’ vaginal tablet, which contains Rosa damascena, Punica granatum L. (Punicaceae), Querqus infectoria Oliv. (Fagaceae), Myrtus communis L. (Myrtaceae) and Nardostachys jatamansi (D.Don) DC. (Caprifoliaceae) could alleviate the symptoms of vulvovaginal candidiasis. Materials and methods A parallel double-blinded placebo-controlled study was done. Eighteen to fifty-year-old women with vulvovaginal candidiasis were divided into the ‘ward’ and placebo groups, 46 individuals in each group. The ‘ward’ group received the ‘ward’ vaginal tablet containing 200 mg of dried extract. Placebo group received a placebo (composed of corn starch and lactose). One tablet was applied through the vagina for 7 consecutive nights. Results Two weeks after medication administration, the vaginal discharge sample of patients was re-cultured; 29 patients (63.045%) in the ‘ward’ group and 6 (13.04%) patients in the placebo group had negative culture (p < 0.001). All clinical symptoms including itching, irritation, and vaginal discharge were significantly reduced in the ‘ward’ group compared with the placebo group following the intervention and the follow up (p < 0.05). Discussion and conclusions The findings suggest the ‘ward’ vaginal tablet could ameliorate vulvovaginal candidiasis. Future larger studies are recommended due to compare the therapeutic effect of the ‘ward’ vaginal tablet with common treatments.
Spinal Wnt5a Plays a Key Role in Spinal Dendritic Spine Remodeling in Neuropathic and Inflammatory Pain Models and in the Proalgesic Effects of Peripheral Wnt3a

Wnt signaling represents a highly versatile signaling system, which plays critical roles in developmental morphogenesis as well as synaptic physiology in adult life and is implicated in a variety of neural disorders. Recently, we demonstrated that Wnt3a is able to recruit multiple noncanonical signaling pathways to alter peripheral sensory neuron function in a nociceptive modality-specific manner. Furthermore, several studies recently reported an important role for Wnt5a acting via canonical and noncanonical signaling in spinal processing of nociception in a number of pathologic pain disorders. Here, using diverse molecular, genetic, and behavioral approaches in mouse models of pain in vivo, we report a novel role for Wnt5a signaling in nociceptive modulation at the structural level. In models of chronic pain, using male and female mice, we found that Wnt5a is released spinally from peripheral sensory neurons, where it recruits the tyrosine kinase receptors Ror2 and Ryk to modulate dendritic spine rearrangement. Blocking the Wnt5a–Ryk/Ror2 axis in spinal dorsal horn neurons prevented activity-dependent dendritic spine remodeling and significantly reduced mechanical hypersensitivity induced by peripheral injury as well as inflammation. Moreover, we observed that peripheral Wnt3a signaling triggers the release of Wnt5a in the spinal cord, and inhibition of spinal Wnt5a signaling attenuates the functional impact of peripheral Wnt3a on nociceptive sensitivity. In conclusion, this study reports a novel role for the Wnt signaling axis in coordinating peripheral and spinal sensitization and shows that targeting Wnt5a–Ryk/ROR2 signaling alleviates both structural and functional mechanisms of nociceptive hypersensitivity in models of chronic pain in vivo. SIGNIFICANCE STATEMENT There is a major need to elucidate molecular mechanisms underlying chronic pain disorders to develop novel therapeutic approaches. Wnt signaling represents a highly versatile signaling system, which plays critical roles during development and adult physiology, and it was implicated in several diseases, including chronic pain conditions. Using mouse models, our study identifies a novel role for Wnt5a signaling in nociceptive modulation at the spinal cord level. We observed that Wnt5a recruits Ror2 and Ryk receptors to enhance dendritic spine density, leading to nociceptive sensitization. Blocking the Wnt5a–Ryk/Ror2 interaction in the spinal dorsal horn prevented spine remodeling and significantly reduced inflammatory and neuropathic hypersensitivity. These findings provide proof-of-concept for targeting spinal Wnt signaling for alleviating nociceptive hypersensitivity in vivo.
Dietary therapy for eosinophilic esophagitis: chances and limitations in the clinical practice

ABSTRACT Introduction Eosinophilic esophagitis (EoE) is a non-Immunoglobulin E-mediated food allergy that currently represents the main cause of dysphagia and food impaction in children and young adults. Diet remains the only therapy targeting the cause of the disease. Relevant advances in recent years allow novel approaches to dietary therapy in EoE. Areas covered An up-to-date review on dietary therapy for EoE is provided, as a potential first-line anti-inflammatory therapy able to induce and maintain remission in a significant proportion of patients. Unpractical elemental diets and suboptimal food allergy testing-directed food restrictions paved the way for empiric elimination diets, which currently are to be considered as the most effective drug-free treatment for EoE. After largely restrictive empiric six-food elimination diets, most efficient step-up approaches now include four-food and two-food elimination diets. The potential of milk-elimination is also discussed. Expert commentary An empiric elimination diet step-up strategy should be currently considered as the initial approach for dietary treatment in EoE patients of all ages. Compared to a top-down strategy, step-up diets reduce the need for endoscopic procedures, shorten diagnostic process times, and avoid unnecessary restrictions. Furthermore, early identification of responders with few food triggers may select best candidates for maintenance dietary therapy.
Opioids Interfere With Deglutitive Inhibition Assessed by Response to Multiple Rapid Swallows During High-Resolution Esophageal Manometry.

INTRODUCTION Normal response to multiple rapid swallows (MRS) during high-resolution esophageal manometry is deglutitive inhibition; opioids may interfere with this. The aim of this study was to evaluate the response to MRS in patients on opioids, not on opioids, and healthy controls. METHODS Response to MRS was evaluated for complete vs impaired inhibition in 72 chronic opioid users, 100 patients not on opioids, and 24 healthy controls. RESULTS Impaired deglutitive inhibition was significantly more frequent in chronic opioid users compared with patients not on opioids and healthy controls (54% vs 14% vs 0%; P < 0.0001). DISCUSSION Impaired deglutitive inhibition during MRS is frequent in opioid users, supporting that opioids interfere with esophageal inhibitory signals.
Endothelial Activation, Acute Kidney Injury, and Cognitive Impairment in Pediatric Severe Malaria

Supplemental Digital Content is available in the text. Objectives: Evaluate the relationship between endothelial activation, malaria complications, and long-term cognitive outcomes in severe malaria survivors. Design: Prospectively cohort study of children with cerebral malaria, severe malarial anemia, or community children. Setting: Mulago National Referral Hospital in Kampala, Uganda. Subjects: Children 18 months to 12 years old with severe malaria (cerebral malaria, n = 253 or severe malarial anemia, n = 211) or community children (n = 206) were followed for 24 months. Interventions: None. Measurements and Main Results: Children underwent neurocognitive evaluation at enrollment (community children) or a week following hospital discharge (severe malaria) and 6, 12, and 24 months follow-up. Endothelial activation was assessed at admission on plasma samples (von Willebrand factor, angiopoietin-1 and angiopoietin-2, soluble intercellular adhesion molecule-1, soluble vascular cell adhesion molecule-1, soluble E-Selectin, and P-Selectin). False discovery rate was used to adjust for multiple comparisons. Severe malaria was associated with widespread endothelial activation compared with community children (p < 0.0001 for all markers). Acute kidney injury was independently associated with changes in von Willebrand factor, soluble intercellular adhesion molecule-1, soluble E-Selectin, P-Selectin, and angiopoietin-2 (p < 0.0001 for all). A log10 increase in angiopoietin-2 was associated with lower cognitive z scores across age groups (children < 5, β –0.42, 95% CI, –0.69 to –0.15, p = 0.002; children ≥ 5, β –0.39, 95% CI, –0.67 to –0.11, p = 0.007) independent of disease severity (coma, number of seizures, acute kidney injury) and sociodemographic factors. Angiopoietin-2 was associated with hemolysis (lactate dehydrogenase, total bilirubin) and inflammation (tumor necrosis factor-α, interleukin-10). In children with cerebral malaria who had a lumbar puncture performed, angiopoietin-2 was associated with blood-brain barrier dysfunction, and markers of neuroinflammation and injury in the cerebrospinal fluid (tumor necrosis factor-α, kynurenic acid, tau). Conclusions: These data support angiopoietin-2 as a measure of disease severity and a risk factor for long-term cognitive injury in children with severe malaria.
Models of interprofessional education for healthcare students: a scoping review

ABSTRACT The interprofessional education (IPE) literature abounds with examples of IPE and their evaluations, invariably demonstrating improved outcomes for collaborative care. The aim of this research was to identify models of IPE in health curricula reported in the literature to clarify key characteristics of the models. Searches were conducted in Pubmed (Ebsco), CINAHL (Ebsco), Cochrane Library, PsychINFO (Ebsco), Scopus, Web of Science, and Google Scholar databases for articles describing models of IPE. A total of 25 papers met the inclusion criteria. Models fell broadly into: (a) extra-curricular activities or partially integrated models (28%), and (b) integrated models, that is, models where IP activities were embedded across the whole curriculum (72%). A total of 40% of included papers presented phased models designed to incrementally develop interprofessional capability. However, major barriers exist to fully integrated interprofessional curricula: they require a major curriculum restructure, and a willingness on the part of health professionals to reconsider their professional identities. A curriculum that focuses on the patient and on ways to deliver the most appropriate personalized care is proposed. In such a curriculum, the focus can shift from profession-based care to expertise-based care that is likely to be delivered by a team of skilled health professionals.