Miracle-dz/UniFAR-FTUs huggingface dataset:
Dietary Niacin Requirement of Juvenile Chinese Mitten Crab, Eriocheir sinensis

Effects of dietary niacin on the growth performance, intestinal histomorphology, body composition, and antioxidant capacity were investigated in the present study to determine the optimum requirement of niacin for juvenile Eriocheir sinensis. All 360 crabs (initial average weight 1.14 ± 0.04 g) were randomly divided into 6 groups with 3 replicates in each group and 20 crabs in each replicate. Crabs were fed with the control diet (0.89 mg/kg) or niacin-supplemented diets (170.54 mg/kg, 347.05 mg/kg, 587.59 mg/kg, 784.85 mg/kg, and 1248.86 mg/kg) for 12 weeks (named as G1, G2, G3, G4, G5, and G6, respectively). The results showed that appropriate dietary niacin (above 347.05 mg/kg) significantly increased the weight gain rate (WGR) and specific growth rate (SGR) (p < 0.05), but did not affect the survival rate (SR), feed conversion ratio (FCR), daily feeding rate (DFR), and molting frequency (MF) of crabs (p > 0.05). The niacin content in the hepatopancreas of crabs in G1 and G2 was significantly lower than that of the other four groups (p < 0.05). Moreover, dietary niacin significantly affected the intestinal histomorphology of crabs, including the number of folds (NF), height of folds (HF), height of microvillus (HMV), and thickness of muscularis (TM) (p < 0.05). Additionally, moderate dietary niacin levels significantly affected the nonspecific immune responses of crabs, by improving the activity of catalase (CAT), glutathione s-transferase (GST), glutathione peroxidase (GSH-Px), and total superoxide dismutase (T-SOD) (p < 0.05). Based on the broken-line model analysis of SGR against dietary niacin level, the dietary niacin requirement of juvenile crabs was suggested to be 419.4 mg/kg.
Dilated convolution based botnet detection model

To address the problems of botnet stealthiness and difficulty in detection, this paper proposes a botnet detection model based on dilated convolution. The model first uses dilated convolution to increase the perceptual field of information and extract features from it, and then uses reflection padding to expand the extracted spatial features with samples, then uses squeeze-and-excitation networks to assign different weights to feature channels, and then uses gate recurrent unit to extract the temporal relationships preserved between features, and finally implements botnet detection. The model is validated on the UNSW-NB15 and CIC-IDS-2017 datasets with 99.4% and 99.3% accuracy, respectively, which verifies the effectiveness of the model for botnet detection.
The Contribution of Integration of Entrepreneurship Education for Economic Development in Public Secondary Schools in Sengerema District, Tanzania

This study assessed the contribution of integration of entrepreneurship education in secondary schools on economic development particularly in Sengerema public secondary schools. The study aimed to identify benefits of entrepreneurship education in secondary schools on economic development, to identify challenges facing entrepreneurship education in secondary schools. The study was grounded by planned behaviour theory by Ajzen 1981. The sample size was 136. The researcher adopted mixed research approach with convergent research design. The research instruments used is questionnaire which had cronbach Alpha coefficient of 0.8 which signifying that the instruments were reliable. For qualitative data interview guide was employed and trustworthiness was observed. The data collected through questionnaires were analysed using SPSS version 21st while the data gathered through interviews were thematically analysed. The findings indicated that entrepreneurship education plays a crucial role on economic development through self-employment, It is the tool for poverty eradication, It encourages creativity and innovation and it is a catalyst for the economic growth. The study recommends that the government should formulate policy which makes entrepreneurship education as independent subject like other subject.
Power-law parametrized quintessence model

We propose a simple power-law parametrized quintessence model with time-varying equation of state and obtain corresponding quintessence potential of this model. This model is compared with Supernova Type Ia (SNIa) Gold sample data, size of baryonic acoustic peak from Sloan Digital Sky Survey (SDSS), the position of the acoustic peak from the CMB observations and structure formation from the 2dFGRS survey and put constrain on the parameters of model. The parameters from the best fit indicates that the equation of state of this model at the present time is w{sub 0}=-1.40{sub -0.65}{sup +0.40} at 1{sigma} confidence level. Finally we calculate the age of universe in this model and compare it with the age of old cosmological objects.
A Bayesian Reanalysis of a Trial of Psilocybin versus Escitalopram for Depression.

Objectives To perform a Bayesian reanalysis of a recent trial of psilocybin (COMP360) versus escitalopram for Major Depressive Disorder (MDD) in order to provide a more informative interpretation of the indeterminate outcome of a previous frequentist analysis. Design Reanalysis of a two-arm double-blind placebo controlled trial. Participants Fifty-nine patients with MDD. Interventions Two doses of psilocybin 25mg and daily oral placebo versus daily escitalopram and 2 doses of psilocybin 1mg, with psychological support for both groups. Outcome measures Quick Inventory of Depressive Symptomatology-Self-Report (QIDS SR-16), and three other depression scales as secondary outcomes: HAMD-17, MADRS, and BDI-1A. Results Using Bayes factors and 'skeptical priors' which bias estimates towards zero, for the hypothesis that psilocybin is superior by any margin, we found indeterminate evidence for QIDS SR-16, strong evidence for BDI-1A and MADRS, and extremely strong evidence for HAMD-17. For the stronger hypothesis that psilocybin is superior by a 'clinically meaningful amount' (using literature defined values of the minimally clinically important difference), we found moderate evidence against it for QIDS SR-16, indeterminate evidence for BDI-1A and MADRS, and moderate evidence supporting it for HAMD-17. Furthermore, across the board we found extremely strong evidence for psilocybin's non-inferiority versus escitalopram. These findings were robust to prior sensitivity analysis. Conclusions This Bayesian reanalysis supports the following inferences: 1) that psilocybin did indeed outperform escitalopram in this trial, but not to an extent that was clinically meaningful--and 2) that psilocybin is almost certainly non-inferior to escitalopram. The present results provide a more precise and nuanced interpretation to previously reported results from this trial, and support the need for further research into the relative efficacy of psilocybin therapy for depression with respect to current leading treatments. Trial registration number NCT03429075.
Multiband superconductivity and nanoscale inhomogeneity at oxide interfaces

The two-dimensional electron gas at the LaTiO3/SrTiO3 or LaAlO3/SrTiO3 oxide interfaces becomes superconducting when the carrier density is tuned by gating. The measured resistance and superfluid density reveal an inhomogeneous superconductivity resulting from percolation of filamentary structures of superconducting "puddles" with randomly distributed critical temperatures, embedded in a non-superconducting matrix. Following the evidence that superconductivity is related to the appearance of high-mobility carriers, we model intra-puddle superconductivity by a multi-band system within a weak coupling BCS scheme. The microscopic parameters, extracted by fitting the transport data with a percolative model, yield a consistent description of the dependence of the average intra-puddle critical temperature and superfluid density on the carrier density.
Work Stressors and Intention to Leave the Current Workplace and Profession: The Mediating Role of Negative Affect at Work

The first aim of this study was to determine whether organisational constraints, interpersonal conflicts at work, workload and negative affect at work have a positive relationship with intention to leave a current job or profession. The second aim was to investigate whether negative affect at work mediates the relationship between work stressors and intention to leave a current job or profession. The study was a quantitative cross-sectional design in nature. Data were collected between March and April 2022. The sample consisted of 306 midwives working in the Polish public health service. The theoretical model was tested using structural equation modelling. The results confirmed positive direct relationships between workload and negative affect with intention to leave the current workplace and intention to leave the midwifery profession in general. The relationships between organisational constraints and interpersonal conflicts at work and intention to leave a job or profession were found to be completely mediated by negative affect at work. Our study revealed that workload is the strongest direct predictor of intention to leave the current job or profession. Organisational constraints and interpersonal conflicts at work lead to an intention to leave a job or profession by inducing negative affect at work. Interpersonal conflicts at work are the strongest predictor of negative affect at work.
Granulocytic MDSC with Deficient CCR5 Alleviates Lipogenesis and Inflammation in Nonalcoholic Fatty Liver Disease

C-C chemokine receptor type 5 (CCR5) positively contributes to the pathogenesis of nonalcoholic fatty liver disease (NAFLD), a common metabolic liver disease associated with chronic inflammation. CCR5 signaling also facilitates the immunosuppressive activity of a group of immature myeloid cells known as granulocytic myeloid-derived suppressor cells (g-MDSCs). While both hepatocyte and g-MDSC express CCR5, how CCR5 coordinates these two distinct cell types in the hepatic microenvironment remains largely unknown. Here, we used in vivo and ex vivo approaches to define the molecular details of how CCR5 mediates the crosstalk between hepatocytes and g-MDSCs in a mouse model of NAFLD. Global CCR5-deficient mice exhibited more severe steatosis, increased hepatic gene expression of lipogenesis, and exacerbated liver damage in diet-induced obesity. Either NAFLD or CCR5-deficiency per se is causative for the increase of g-MDSCs. Purified g-MDSCs have a higher survival rate in the fatty liver microenvironment, and blockade of CCR5 significantly decreases g-MDSCs’ expression of anti-inflammatory factors. On the other hand, the null of CCR5 signaling increases hepatocytes’ expression of lipogenic genes in the NAFLD microenvironment. Most importantly, inhibiting g-MDSCs’ CCR5 signaling in the fatty liver microenvironment dramatically reduces STAT3 signaling, lipogenic, and pro-inflammatory gene expression in primary hepatocytes. Adoptive cell transfer experiments further demonstrate that CCR5-deficient g-MDSCs mitigate hepatic lipogenic gene expression without facilitating pro-inflammatory cytokine production and liver damage in NAFLD mice. These results suggest that targeting g-MDSCs’ CCR5 signaling might serve as a potential therapeutic strategy for NAFLD.
Multiple Light-Dark Signals Regulate Expression of the DEAD-Box RNA Helicase CrhR in Synechocystis PCC 6803

Since oxygenic photosynthesis evolved in the common ancestor of cyanobacteria during the Archean, a range of sensing and response strategies evolved to allow efficient acclimation to the fluctuating light conditions experienced in the diverse environments they inhabit. However, how these regulatory mechanisms are assimilated at the molecular level to coordinate individual gene expression is still being elucidated. Here, we demonstrate that integration of a series of three distinct light signals generate an unexpectedly complex network regulating expression of the sole DEAD-box RNA helicase, CrhR, encoded in Synechocystis sp. PCC 6803. The mechanisms function at the transcriptional, translational and post-translation levels, fine-tuning CrhR abundance to permit rapid acclimation to fluctuating light and temperature regimes. CrhR abundance is enhanced 15-fold by low temperature stress. We initially confirmed that the primary mechanism controlling crhR transcript accumulation at 20 °C requires a light quantity-driven reduction of the redox poise in the vicinity of the plastoquinone pool. Once transcribed, a specific light quality cue, a red light signal, was required for crhR translation, far-red reversal of which indicates a phytochrome-mediated mechanism. Examination of CrhR repression at 30 °C revealed that a redox- and light quality-independent light signal was required to initiate CrhR degradation. The crucial role of light was further revealed by the observation that dark conditions superseded the light signals required to initiate each of these regulatory processes. The findings reveal an unexpected complexity of light-dark sensing and signaling that regulate expression of an individual gene in cyanobacteria, an integrated mechanism of environmental perception not previously reported.
Energy Devices for Clipless–Sutureless Laparoscopic Appendectomy: A Systematic Review and Meta-Analysis on Utility and Safety

Background and Objectives: While laparoscopic appendectomy is standardized, techniques for appendiceal stump closure and mesoappendix division remain variable. Novel vessel sealing techniques are increasingly utilized ubiquitously. We sought to systematically summarize all relevant data and to define the current evidence on the safety and utility of energy devices for clipless–sutureless laparoscopic appendectomy in this systematic review and meta-analysis. Materials and Methods: This review was conducted following the PRISMA guidelines. PubMed, Embase, Scopus, and Web of Science were systematically searched. Inclusion criteria included studies with laparoscopic appendectomy for appendicitis. The intervention included patients undergoing division of mesoappendix and/or securing of the appendicular base using diathermy (Monopolar or Bipolar or LigaSure Sealing Device) or Harmonic Scalpel (Group A) compared to patients undergoing division of mesoappendix and/or securing of the appendicular base using endoclip or Hem-o-lok or ligature (Group B). The methodological quality of the included studies was assessed using the Downs and Black scale. The outcomes of surgical site infection (SSI) or intra-abdominal collection, postoperative ileus, average operative duration, and length of hospital stay (LHS) were compared. Results: Six comparative studies were included; three were retrospective, two were prospective, and one was ambispective. Meta-analysis revealed a shorter operative duration in Group A with respect to appendicular base ligation (MD −12.34, 95% CI −16.57 to −8.11, p < 0.00001) and mesoappendix division (MD −8.06, 95% CI −14.03 to −2.09, p = 0.008). The pooled risk ratios showed no difference in SSI between groups. Additionally, no difference was observed in LHS. The risk of postoperative ileus was higher in group B regarding mesoappendix division (RR 0.56, 95% CI 0.34 to 0.93, p = 0.02), but no difference was found concerning appendicular base ligation. The included studies showed a moderate-to-high risk of bias. Conclusions: Clipless–sutureless laparoscopic appendectomy is safe and fast. Postoperative ileus seems less common with energy devices for mesoappendix division. However, the studies included have a moderate-to-high risk of bias. Further studies addressing the individual devices with surgeons of similar levels are needed.
Low X-ray luminosity galaxy clusters – II. Optical properties and morphological content at 0.18 < z < 0.70

Fil: Nilo Castellon, Jose Luis Emilio. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet - Cordoba. Instituto de Astronomia Teorica y Experimental. Universidad Nacional de Cordoba. Observatorio Astronomico de Cordoba. Instituto de Astronomia Teorica y Experimental; Argentina
Strong boundary values : independence of the defining function and spaces of test functions

The notion of “strong boundary values” was introduced by the authors in the local theory of hyperfunction boundary values (boundary values of functions with unrestricted growth, not necessarily solutions of a PDE). In this paper two points are clariﬁed, at least in the global setting (compact boundaries): independence with respect to the deﬁning function that deﬁnes the boundary, and the spaces of test functions to be used. The proofs rely crucially on simple results in spectral asymptotics.
AN EMPIRICAL MEASURE OF THE RATE OF WHITE DWARF COOLING IN 47 TUCANAE

We present an empirical determination of the white dwarf cooling sequence in the globular cluster 47 Tucanae. Using spectral models, we determine temperatures for 887 objects from Wide Field Camera 3 data, as well as 292 objects from data taken with the Advanced Camera for Surveys. We make the assumption that the rate of white dwarf formation in the cluster is constant. Stellar evolution models are then used to determine the rate at which objects are leaving the main sequence, which must be the same as the rate at which objects are arriving on the white dwarf sequence in our field. The result is an empirically derived relation between temperature (Teff) and time (t) on the white dwarf cooling sequence. Comparing this result to theoretical cooling models, we find general agreement with the expected slopes between 20,000 K and 30,000 K and between 6000 K and 20,000 K, but the transition to the Mestel cooling rate of Teff∝t−0.4 is found to occur at hotter temperatures, and more abruptly than is predicted by any of these models.
First successful prediction of a convective equatorial ionospheric storm using solar wind parameters

One of the major challenges of the National Space Weather Program in the United States is to predict the generation of intense turbulence in the equatorial and low‐latitude ionosphere. We term this a convective equatorial ionospheric storm since, much like a thunderstorm, low‐density media erupt upward, releasing stored gravitational energy. This is an important phenomenon since both communication and navigational systems can be severely affected by the associated turbulence. Here, for the first time, we use solar wind data obtained upstream of the Earth and a physics‐based assimilative model to successfully predict such an event during a strong magnetic storm in November 2004.
Translucent Zone Between Autograft and Endplate Two Months Postoperatively Is an Independent Predictor of Delayed Osseous Union in Elderly Patients With Posterior Lumbar Interbody Fusion Surgery

Background Delayed union or pseudoarthrosis after posterior lumbar interbody fusion (PLIF) is associated with poor outcomes in health-related quality of life. Therefore, it is important to achieve earlier solid fusion for a successful clinical outcome after PLIF. A few authors reported that biomechanical factors may influence spinal fusion rates. The purpose of our retrospective study was to evaluate the independent predictors of delayed osseous union related to intraoperative procedures of PLIF, and to find ways to reduce delayed osseous union. Methods This was a retrospective study of a completed trial. We reviewed 66 elderly patients with osteoporosis after PLIF (all female, mean age 71 years, follow-up period over 6 months). Lumbar computed tomography scans at 2 months postoperatively were examined for the presence of a translucent zone between autograft and endplate (more than 50% of vertebral diameter), and autograft position with bone bridging (anterior, central, or posterior). Osseous union was assessed by using computed tomography 6 months postoperatively. Results Thirty-three patients (50%) showed complete osseous union, while 33 did not. A translucent zone between autograft and endplate two months postoperatively was observed in nine patients (27%) in the union group and in 23 (70%) in the nonunion group (p<0.01). Autograft position with bone bridging two months postoperatively was anterior, central, and posterior in 17 (52%), 30 (91%), and 20 patients (61%) in the union group, and in 12 (36%), 20 (61%), and seven patients (21%) in the nonunion group (p=0.22, p<0.01, and p<0.01), respectively. Multivariate logistic regression analysis showed that the presence of a translucent zone between autograft and endplate (odds ratio, 0.101; 95% confidence interval: 0.026-0.398; p<0.01) and teriparatide administration (odds ratio, 8.810; 95% confidence interval: 2.222-34.936; p<0.01) were independently associated with osseous union after PLIF. Conclusions A translucent zone between autograft and endplate at two months postoperatively independently predicted delayed osseous union within six months after PLIF. Complete osseous union rates were higher in patients with posterior bone bridging two months postoperatively than in those without. These findings apart from preoperative predictors of osseous union might serve as indicators of how intraoperative techniques affects osseous union enhancement.
The population of hot subdwarf stars studied with Gaia

Based on data from the ESA Gaia Data Release 2 (DR2) and several ground-based, multi-band photometry surveys we have compiled an all-sky catalogue of 39 800 hot subluminous star candidates selected in Gaia DR2 by means of colour, absolute magnitude, and reduced proper motion cuts. We expect the majority of the candidates to be hot subdwarf stars of spectral type B and O, followed by blue horizontal branch stars of late B-type (HBB), hot post-AGB stars, and central stars of planetary nebulae. The contamination by cooler stars should be about 10%. The catalogue is magnitude limited to Gaia G < 19 mag and covers the whole sky. Except within the Galactic plane and LMC/SMC regions, we expect the catalogue to be almost complete up to about 1.5 kpc. The main purpose of this catalogue is to serve as input target list for the large-scale photometric and spectroscopic surveys which are ongoing or scheduled to start in the coming years. In the long run, securing a statistically significant sample of spectroscopically confirmed hot subluminous stars is key to advance towards a more detailed understanding of the latest stages of stellar evolution for single and binary stars.
Conserved currents, superpotentials and cosmological perturbations

Conserved vectors are divergencies of superpotentials. In field theory on curved backgrounds, they are useful in calculating global ‘charges’ in arbitrary coordinates and local conserved quantities for small perturbations with specific gauge conditions. Superpotentials are, however, ill–defined. A new criterion of Julia and Silva selects uniquely for Dirichlet boundary conditions the ‘KBL superpotential’ as proposed by Katz, Bičák and Lynden–Bell, which has remarkable properties. Here, we show that a Belinfante–type addition to the KBL superpotential in general relativity gives an expression that is independent of boundary conditions defined by a variational principle. The modified superpotential has the same global properties as the KBL one, except for angular momentum at null infinity, and it does not differ from the KBL superpotential in the linearized theory of gravitation. As an illustration in linearized theory on curved backgrounds, we calculate conserved quantities for small perturbations on a Friedmann–Robertson–Walker spacetime associated with conformal Killing vectors. Our unifying view relates a number of applications in cosmology found in the literature. Globally conserved quantities have simple physical interpretations in the ‘uniform Hubble expansion’ gauge.