Miracle-dz/UniFAR-FTUs huggingface dataset:
Caporaso, Nicola and Whitworth, Martin B. and Grebby, Stephen and Fisk, Ian D. (2018) Rapid prediction of single green coffee bean moisture and lipid content

Hyperspectral imaging (1000e2500 nm) was used for rapid prediction of moisture and total lipid content in intact green coffee beans on a single bean basis. Arabica and Robusta samples from several growing locations were scanned using a “push-broom” system. Hypercubes were segmented to select single beans, and average spectra were measured for each bean. Partial Least Squares regression was used to build quantitative prediction models on single beans (n1⁄4 320e350). The models exhibited good performance and acceptable prediction errors of ~0.28% for moisture and ~0.89% for lipids. This study represents the first time that HSI-based quantitative prediction models have been developed for coffee, and specifically green coffee beans. In addition, this is the first attempt to build such models using single intact coffee beans. The composition variability between beans was studied, and fat and moisture distribution were visualized within individual coffee beans. This rapid, non-destructive approach could have important applications for research laboratories, breeding programmes, and for rapid screening for industry. © 2018 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Synergism of Gamma Interferon and Interleukin-5 in the Control of Murine Filariasis

There has been a prevailing perception that Th1 and Th2 immune responses induce antagonistic immune effector mechanisms during an infection. We investigated the role of the Th1 cytokine gamma interferon (IFN) and the Th2 cytokine interleukin-5 (IL-5) in murine filariasis infections with the rodent filarial nematode Litomosoides sigmodontis with regard to immune responses to the parasite. Earlier data showed an important role for IL-5 and IFNin effective immune responses to filarial infection. Therefore, in this study it was asked whether IL-5 and IFNact synergistically or antagonistically. Indeed, IL-5 as well as IFNknockout (KO) mice show a higher worm load than the wild-type controls. IFN/IL-5 double-KO mice had a significantly higher worm load than any of the single-KO mice, suggesting a synergism between IFNand IL-5 in controlling worm infection. Neutrophils are known to play an important role for the containment and encapsulation process of the worms. In infected IFNKO, IL-5 KO, and IFN/IL-5 double-KO mice, neutrophils were significantly reduced in chemotactic activity levels compared to controls. In addition, the level of phagocytosis activity of neutrophils from IFN/IL-5 double-KO mice was further decreased in comparison to that of the single-KO mice. Levels of tumor necrosis factor alpha, which is an important factor for neutrophil activation, were found to be reduced in macrophages from KO mice. In conclusion, these results argue for immune effector mechanisms in murine filarial infection that are dependent on both IFNand IL-5. Synergistic effects of the two cytokines may be mediated, at least in part, by neutrophils for the control of adult worms.
Influence of low and high intensity physical exercise on hypernociception threshold and other parameters of rats

Physical exercise practice is an important habit to maintain the physical and emotional well-being of those who regularly adopt it, and can bring great benefits to health. However, depending on the type, intensity, frequency and duration of the exercises, they can also do a certain degree of harm to the organism. As a benefit, the role of physical exercise is described in the specific and non-specific immune function and, in the latter, the inflammatory process stands out. Therefore, the purpose of this study was to show the effects of low and high intensity physical exercises on hypernociception, and to evaluate the body mass and the relative weight of some organs in rats. For the study, male adult Wistar rats were used and submitted (trained group) or not submitted (non-trained group) to physical exercises on an ergometric treadmill. The acute inflammation was induced by an injection of carrageenin-0.5% into the plantar tissue of the left hind paw of each rat and the nociception was measured by the plantar test before and after 1, 2, 3, 4, 6, 8 and 24 hours. At the end of the evaluations, the rats were submitted to deep anesthesia until their euthanasia, to collect and weigh the adrenal glands, heart, spleen and kidneys, and to subsequent histopathological study of those tissues. The statistical analysis of the results showed a significant increase (P < 0.05) of the hypernoniception threshold in H 2 , H 3 , H 4 and H 6 moments in animals trained at high intensity. There was also a significant reduction (P < 0.05) in body mass besides hypertrophy of the adrenal glands and heart and an increase in the kidneys relative weight of the rats trained at high intensity, in addition to adrenal hypertrophy of the animals trained at low intensity. There were no statistically significant changes in the other parameters evaluated in this study. We concluded that physical exercises on a treadmill were capable of changing the nociception, body mass and the relative weight of some organs, but in a way that was dependent on the exercises protocol applied to the animals.
Manuscript title: Traditional gender roles and effects of dementia caregiving within a South Asian ethnic group in England Running title: Gender roles and dementia caregiving in a South Asian group

Background: Despite the integral role that women play in the care of older adults in South Asian families, limited empirical data are available on the impact of migration from South Asia to England. The purpose of this research was to examine caring for a family member with dementia from a gender role perspective. Methods: Data were gathered in two phases: 1) focus groups and 2) semistructured interviews. Focus groups were held with the general public and semistructured interviews were conducted with family carers. Data were audio-recorded and analysed using thematic analysis. The NVivo qualitative software was utilised to simplify the thematic analysis. Results: While traditionally family care for frail older adults has been mainly provided by women in South Asian families, this study’s samples revealed how women’s attitudes towards caregiving are changing in British societies. Conclusion: There remained a dearth of research about socioeconomic transformations in South Asian women’s migration to Western countries which could contribute to deterring them from providing family care. More research is warranted to understand the ways in which migration shapes gender relations in the South Asian families and its impact on care for the frail elderly.
shikonin-loaded thermosensitive micelle

and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). International Journal of Nanomedicine 2017:12 4019–4035 International Journal of Nanomedicine Dovepress
Interpreting EORTC QLQ-C30 scores as minimally importantly different (MID) for patients with malignant melanoma

eprints@whiterose.ac.uk https://eprints.whiterose.ac.uk/ Reuse This article is distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs (CC BY-NC-ND) licence. This licence only allows you to download this work and share it with others as long as you credit the authors, but you can’t change the article in any way or use it commercially. More information and the full terms of the licence here: https://creativecommons.org/licenses/
COMPARISON IN OUTCOME BETWEEN HARMONIC SCALPEL AND CONVENTIONAL METHODS IN HEMORRHOIDECTOMY

Background: Recently, efforts were made to find less painful and less complicated surgical methods for treatment of hemorrhoids. A variety of instruments used, including circular staplers, harmonic scalpels, lasers, and bipolar electrothermal devices. Aim of study: To compare the outcome of patients with grade III or IV disease who underwent hemorrhoidectomy using harmonic scalpel or conventional closed technique. Patients and Methods: Comparative prospective study included 60 patients underwent hemorrhoidectomy was conducted in the surgical unit, Department of Surgery, Al-Numan Teaching Hospital in Baghdad during a period of 18 months from 1 st of Feb, 2018 – 31th Jul, 2019. They divided randomly into two equal groups: harmonic group treated by harmonic scalpel method and conventional group treated by conventional method. They were compared regarding Intra operative bleeding, operative time, postoperative pain, early postoperative complications, length of hospital stay, and duration to return to normal activity. Patients with thrombosed or strangulated hemorrhoids, with a known case of tendencies for bleeding, with concomitant perianal disease, with a history of recurrent perianal surgeries, or those unfit for surgery or anesthesia were excluded from this study. Results: No statistical significant differences between study groups regarding age, gender, BMI level, and grade of disease. Bleeding was significantly less than bleeding occurred in patients treated by conventional method. Postoperative pain and time to return to work and daily activities were significantly less in patients managed by harmonic scalpel method. Conclusion: Both of harmonic scalpel or conventional method are an effective and safe procedures in hemorrhoidectomy. Harmonic scalpel method is preferred as it reduces the postoperative pain and bleeding and duration of returning to work and daily activities compared to conventional method.
a-Amylase Inhibitor, Not Phytohemagglutinin, Explains Resistance of Common Bean Seeds to Cowpea Weevil1

There are claims that phytohemagglutinin (PHA), the lectin of common bean, Phaseolus vulgaris, is toxic when fed to the cowpea weevil, Callosobruchus maculatus, and that PHA serves as the chemical defense against this seed-feeding bruchid beetle (DH Janzen, HB Juster, IE Liener [1976] Science 192: 795-796; J Sci Food Agric 35: 373-380). However, our studies indicate that neither PHA nor its isolectins have detrimental effects when fed to the cowpea weevil. To explain these contradictory results we characterized the commercial lectin source used by A. M. R. Gatehouse, F. M. Dewey, J. Dove, K. A. Fenton, A. Pusztai (1984, J Sci Food Agric 35: 373-380). We demonstrate here that the toxic effects of PHA to cowpea weevil are due to an a-amylase inhibitor contaminant in the commercial preparation.
Edinburgh Research Explorer Features of 20133 UK patients in hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: prospective observational cohort study

Objective To characterise the clinical features of patients admitted to hospital with coronavirus disease 2019 (covid-19) in the United Kingdom during the growth phase of the first wave of this outbreak who were enrolled in the International Severe Acute Respiratory and emerging Infections Consortium (ISARIC) World Health Organization (WHO) Clinical Characterisation Protocol UK (CCP-UK) study, and to explore risk factors associated with mortality in hospital. Design Prospective observational cohort study with rapid data gathering and near real time analysis. setting A case report ISARIC time
TASTE-AROMA INTERACTIONS AS A SUGAR REDUCTION STRATEGY IN FLAVORED MILK

Food manufacturers are actively seeking methods f r reducing sugar in products without compromising flavor, functionality, and consumer acceptability. The use of alternative sweeteners is the most common strategy; however, consumers have become wary of these for various reasons. Cross -modal interactions, in particular taste -aroma interactions, ha ve been proposed as another strate gy for sugar reduction , as i t has been shown that the addition of a congruent aroma to a sweetened matrix may enhance the and vice versa . Currently there are two underlying factors that make this phenomenon difficult to accept as a real occurrence: 1) most studies have been done in model solutions or model foods and not real foods , and 2) enhancement is either present or disappears depending on the sensory testing method and consequently the perceptual strategy used. Enhancement s thus have been attributed to what is known as the i.e., when panelists are given a limited ballot of attributes to rate, they ar perceptions into one category, causing what seems to be an enhancement. When panelists are given an extended ballot of salient product attributes, they are then able to separate these perceptions into individual components, causing enhancements to disappear. However, this method of rating is not representative of a typical eating situati on for the average consumer. Instead of this analytical mindset that is employed when rating scales are used, and hedonic . This integration of perceptions is known as the synthetic strategy nd methods that encourage such behavior have been proposed as an alternative approach when testing for enhancements in taste -aroma interaction studies . The following chapters outline studies to answer the following questions:
Phase II Open Label Study of the oral VEGF-Receptor inhibitor PTK787/ZK222584 (Vatalanib) in Adult Patients with Refractory or Relapsed Diffuse Large B Cell Lymphoma

PTK787/ZK222584 (Vatalanib), an orally active inhibitor of vascular endothelial growth factor receptors (VEGF-Rs), was evaluated in this phase II study of 20 patients with relapsed/refractory diffuse large B-cell lymphoma (DLBCL). Patients received once daily PTK787/ZK222584 at a target dose of 1250mg. Eighteen patients were evaluable for response: 1 patient had a complete response (CR), 6 patients had stable disease but subsequently progressed, 10 patients had progressive disease by 3 cycles, and 1 subject withdrew before response evaluation. The patient who attained a CR underwent autologous stem cell transplantation and remains disease free 76 months after study completion. There were no grade 4 toxicities. Grade 3 thrombocytopenia occurred in 20% and grade 3 hypertension occurred in 10%. There were no episodes of grade 3 proteinuria. In conclusion, PTK787/ZK222584 was well tolerated in a heavily pretreated population of DLBCL patients, though its therapeutic potential as a single agent in DLBCL appears limited.
PERFORMANCE ANALYSIS OF TRANSCRITICAL CO2 REFRIGERATION SYSTEM FOR SUPERMARKET APPLICATION

Environmental issues becomes a priority on the refrigeration system development. The main issues are global warming and ozone depletion which are emitted from the conventional refrigeration system. One of the natural and clean refrigerants is Carbon dioxide (CO2). CO2 refrigeration system however still has low performance when operating at high ambient temperature. This study aim is to investigate the performance of CO2 transcritical refrigeration system in high outdoor temperature. The research was carried out by theoretical study and numerical analysis of the refrigeration system using the EES (Engineering Equation Solver) program. Data input and simulation validation were obtained from experimental and secondary data. The result showed that the coefficient of performance (COP) decreased gradually with the outdoor temperature variation increasing. With temperature input increases between 25oC – 45oC, the performance (indicated by overall COP) decreased by 3.0 %. These results will be significantly important for a preliminary reference to improve the CO2 refrigeration system design in hot climate temperature application.
Final report of the supplementary comparison EURAMET.EM-S31 comparison of capacitance and capacitance ratio

Within the framework of the supplementary comparison EURAMET.EM-S31, 'Comparison of capacitance and capacitance ratio', five participants (the BIPM, METAS, LNE, PTB, and VSL) inter-compared their capacitance realisations traced to the quantum Hall resistance measured at either ac or dc. The measurands were the capacitance values of three 10 pF standards and one 100 pF standard, and optionally their voltage and frequency dependences. Because the results were not fully satisfying, the circulation was repeated, augmented by a link to the NMIA calculable capacitor. Also two ac-dc resistors were circulated and their frequency dependences were measured in terms of the ac-dc resistance standards involved in the particular capacitance realisations, to allow inter-comparison of these resistance standards. At the end and in any case, a good agreement is achieved within the expanded uncertainties at coverage factor k = 2. Furthermore, the comparison led to new insight regarding the stability and travelling behaviour of the capacitance standards and, by virtue of the link to the NMIA calculable capacitor, to a determination of the von Klitzing constant in agreement with the 2014 CODATA value. Main text To reach the main text of this paper, click on Final Report. Note that this text is that which appears in Appendix B of the BIPM key comparison database kcdb.bipm. org/. The final report has been peer-reviewed and approved for publication by the CCEM, according to the provisions of the CIPM Mutual Recognition Arrangement (CIPM MRA).
HESPERIDIN (HDN) AN ANTIOXIDANT FLAVONOID PREVENTS CARBON TETRACHLORIDE (CCl4)-INDUCED HEPATIC TOXICITY IN MALE ALBINO RATS

Background: Through this research work, an experimental study was conducted to evaluate the protective effects of an antioxidant (Hesperidin) on carbon tetrachloride-induced hepatic toxicity. This effect was evaluated through assessment of liver functions as well as histopathological changes in livers of rats exposed to Hesperidin prior to carbon tetrachloride. Materials and Methods: Thirty two male albino rats (160-200 gm) were chosen as an animal model for this study and distributed to four equal groups each of 8 rats. Group I (Negative control group, i.e., No CCL4 or HDN). Group II (Positive control group): received vehicle (Carboxymethyl Cellulose) for 10 days and were challenged with CCl4 2 ml/kg/SC (40% v/v in olive oil) on 8th day. Group III (HDN: 100 mg/kg): rats received HDN continuously for 8 days. On 8th day, they received CCl4 2ml/kg/SC in olive oil. HDN was further continued for 2 more days. Group IV (HDN: 200 mg/kg): rats received HDN continuously for 8 days. On 8th day, they received CCl4 2ml/kg/SC in olive oil. HDN was further continued for 2 more days. After ten days of treatment, the following were assessed: liver enzymes, tumour necrosis factor –alpha, oxidant parameters as malondialdehyde and antioxidant parameters as glutathione, superoxide dismutase, and total antioxidant capacity. Histopathological examination of the liver tissues was conducted. Results: Hesperidin in the dose of 100 and 200 mg/kg produced a significant decrease in the levels of liver enzymes, alanine aminotransferase (ALT) and aspartate aminotransferase (AST),tumour necrosis factor–alpha(TNF-α), and oxidant parameters as malondialdehyde (MDA). Antioxidant parameters as glutathione (GSH), superoxide dismutase (SOD), and total antioxidant capacity (T-AOC), also have shown significant increase. These findings were confirmatory to histopathology. Conclusion: Hesperidin in a dose of 100 and 200 mg/kg offers significant protection against hepatotoxicity produced by CCl4 in albino rats, but this protection is dose-dependent.
Investigation of the Nucleation Kinetics of Bi and Δ-Bi2O3 During Electro-Deposition on Substrate ITO

Bismuth and there oxide (δ-Bi2O3) thin films were deposited on ITO substrates by electro-deposition method. First a cyclic voltammetry study, over a wide range of potentials, with the mounting of three electrodes and an electrolytic solution of 0.01M Bi(NO3)3.5H2O, 0.25M tartaric acid and 2.5M KOH. Towards cathode potential -900mV / SCE we observed the peak of reduction of Bi (III) to Bi (0). When scanning towards increasing potentials we observed a nucleation loop on the electrode, which indicates that there is nucleation, followed by an oxidation peak of Bi (0) to Bi (III). Then we carried out a study of the germination kinetics by carrying out transients current at potentials close to that of reduction peak. The comparison of our transients curves obtained by the chrono-amperometric method with the theoretical transients curves of Charifker and Hills allows us to say that the nucleation is three-dimensional and progressive at a poteniel of -940mV and -950mV but, at a potential of -980 that seems rather for small deposition time a progressive nucleation that can change to an instantaneous nucleation. The characterization of one sample was carried out by X-Ray diffraction, showed that the film was pseudo-fluorite structure. The preferred orientation of the crystallites is (200) for the as deposited film.
From Prediabetes to Type 2 diabetes in Obese Youth: Pathophysiological Characteristics Along the Spectrum of Glucose Dysregulation

1. Division of Weight Management and Wellness, Children’s Hospital of Pittsburgh, Pennsylvania 2. Division of Pediatric Endocrinology, Metabolism and Diabetes Mellitus 3. Children’s Hospital at Scott & White, Texas A & M Health Science Center COM Please address correspondence to: Fida Bacha, M.D. Email: Fida.Bacha@chp.edu Submitted 2 January 2010 and accepted 23 June 2010. This is an uncopyedited electronic version of an article accepted for publication in Diabetes Care. The American Diabetes Association, publisher of Diabetes Care, is not responsible for any errors or omissions in this version of the manuscript or any version derived from it by third parties. The definitive publisherauthenticated version will be available in a future issue of Diabetes Care in print and online at http://care.diabetesjournals. org. Diabetes Care Publish Ahead of Print, published online June 30, 2010
SPATIO-TEMPORAL IMPACT OF SELF-FINANCED ROTAVIRUS VACCINATION ON 1 ROTAVIRUS AND ACUTE GASTROENTERITIS HOSPITALISATIONS IN

Background: Several studies have shown a substantial impact of Rotavirus (RV) vaccination on 17 the burden of RV and all-cause acute gastroenteritis (AGE). However, the results of 18 most impact studies could be confused by a dynamic and complex space-time were space and time dependent. This study improves the methodologies commonly 38 used to estimate the RV vaccine impact and their interpretation.
OP-NDTJ180177 28..34

Cardiovascular disease (CVD) is a highly common complication and the first cause of death in patients with end-stage renal disease (ESRD) on haemodialysis (HD). In this population, mortality due to CVD is 20 times higher than in the general population and the majority of maintenance HD patients have CVD. This is likely due to ventricular hypertrophy as well as non-traditional risk factors, such as chronic volume overload, anaemia, inflammation, oxidative stress, chronic kidney disease–mineral bone disorder and other aspects of the ‘uraemic milieu’. Better understanding the impact of these numerous factors on CVD would be an important step for prevention and treatment. In this review we focus non-traditional CVD risk factors in HD patients.
Project Managers and Functional Managers: A Case Study of Job Satisfaction in a Matrix Organization

Information regarding job satisfaction within an organization using a matrix structure is limited. This paper provides empirical evidence regarding the difference in job satisfaction between project managers and functional managers in one matrix organization: a government research and development center. Key findings of this research include the identification of the factors that provide job satisfaction for both groups and the significant difference in job satisfaction between the groups. The perceived efficiencies provided by the matrix structure may be negated by the lack of job satisfaction experienced by the functional managers.