Miracle-dz/UniFAR-FTUs huggingface dataset:
DMM019083 527..541

Ciliopathies are a group of developmental disorders that manifest with multi-organ anomalies. Mutations in TMEM67 (MKS3) cause a range of human ciliopathies, including Meckel-Gruber and Joubert syndromes. In this study we describe multi-organ developmental abnormalities in the Tmem67 knockout mouse that closely resemble those seen in Wnt5a and Ror2 knockout mice. These include pulmonary hypoplasia, ventricular septal defects, shortening of the body longitudinal axis, limb abnormalities, and cochlear hair cell stereociliary bundle orientation and basal body/ kinocilium positioning defects. The basal body/kinocilium complex was often uncoupled from the hair bundle, suggesting aberrant basal body migration, although planar cell polarity and apical planar asymmetry in the organ of Corti were normal. TMEM67 (meckelin) is essential for phosphorylation of the non-canonical Wnt receptor ROR2 (receptor-tyrosine-kinase-like orphan receptor 2) upon stimulation with Wnt5a-conditioned medium. ROR2 also colocalises and interacts with TMEM67 at the ciliary transition zone. Additionally, the extracellular N-terminal domain of TMEM67 preferentially binds to Wnt5a in an in vitro binding assay. Cultured lungs of Tmem67 mutant mice failed to respond to stimulation of epithelial branching morphogenesis by Wnt5a. Wnt5a also inhibited both the Shh and canonical Wnt/β-catenin signalling pathways in wild-type embryonic lung. Pulmonary hypoplasia phenotypes, including loss of correct epithelial branching morphogenesis and cell polarity, were rescued by stimulating the non-canonical Wnt pathway downstream of the Wnt5a-TMEM67-ROR2 axis by activating RhoA. We propose that TMEM67 is a receptor that has a main role in non-canonical Wnt signalling, mediated byWnt5a and ROR2, and normally represses Shh signalling. Downstream therapeutic targeting of the Wnt5a-TMEM67-ROR2 axis might, therefore, reduce or prevent pulmonary hypoplasia in ciliopathies and other congenital conditions.
Price Manipulation with Positive Feedback Traders∗

This paper investigates the price manipulation that exploits positive feedback traders in a continuous auction market. I characterize the class of pricing rules of competitive liquidity providers that prevent the price manipulation, where the pricing rule is a function that maps an aggregate market order to a uniform trading price. The main result is to show that a broad and plausible class of pricing rules cannot prevent price manipulation by a large speculator.
The northern North Atlantic Ocean mean circulation in the early 21 st Century 1 2

25 The decadal mean circulation in the northern North Atlantic was assessed for the early 21 26 century from repeated ship-based measurements along the Greenland-Portugal OVIDE line, 27 from satellite altimetry and from earlier reported transports across 59.5°N and at the 28 Greenland-Scotland sills. The remarkable quantitative agreement between all data sets 29 allowed us to draw circulation pathways with a high level of confidence. The North Atlantic 30 Current (NAC) system is composed of three main branches, referred to as the northern, 31 central and southern branches, which were traced from the Mid-Atlantic Ridge (MAR), to the 32 Irminger Sea, the Greenland-Scotland Ridge and the subtropical gyre. At OVIDE, the 33 northern and central branches of the NAC fill the whole water column and their top-to-bottom 34 integrated transports were estimated at 11.0 ± 3 Sv and 14.2 ± 6.4 Sv (1 Sv = 10 m s), 35 respectively. Those two branches feed the cyclonic circulation in the Iceland Basin and the 36 flow over the Reykjanes Ridge into the Irminger Sea. This cross-ridge flow was estimated at 37 11.3 ± 4.2 Sv westward, north of 58.5°N. The southern NAC branch is strongly surface38 intensified and most of its top-to-bottom integrated transport, estimated at 16.6 ± 2 Sv, is 39 found in the upper layer. It is composed of two parts: the northern part contributes to the flow 40 over the Rockall Plateau and through the Rockall Trough towards the Iceland-Scotland Ridge; 41 the southern part feeds the anticyclonic circulation towards the subtropical gyre. Summing 42 over the three NAC branches, the top-to-bottom transport of the NAC across OVIDE was 43 estimated at 41.8 ± 3.7 Sv. Because of the surface-intensification of the southern NAC 44 branch, the intermediate water is transported to the northeast Atlantic mostly by the northern 45 and central branches of the NAC (11.9 ± 1.8 Sv eastward). This water circulates cyclonically 46 in the Iceland Basin and anticyclonically in the West European Basin, with similar transport 47 intensities. In the deep layer of the Iceland Basin, Iceland-Scotland Overflow Water (ISOW) 48 spreads southwestward along three pathways on the eastern flank of the Reykjanes Ridge. The 49
Clinical Study of Internal and External Treatment of Gegen Qinlian Wutan Decoction in Active Ulcerative Colitis

Objective:To observer the therapeutic effect of Gegen Qinlian Wutan decoction on tumor necrosis factor-α(TNF-α),interleukin-6(IL-6) and interleukin-8(IL-8) in patients with active ulcerative colitis(UC). Method: Sixty cases with ulcerative colitis were divided into the treatment group and the control randomly.The treatment group was given Gegen Qinlian Wutan decoction by oral administration.The control group was given Sulfasalazine enteric-coated tablets.TNF-α,IL-6 and IL-8 in serum were detected by ELISA for all patients before and after treatment,and compared with 30 healthy volunteers.Result: Creative effects in the treatment was obviously better than in the control group,the difference was significant(P0.05). After treatment,compared with the control group,the treatment group had the lower plasma levels of TNF-α,IL-6 and IL-8(P0.05). Conclusion: Gegen Qinlian Wutan decoction has obvious effect on ulcerative colitis.The down regulation of the expressions of TNF-α,IL-6 and IL-8 in serum may be one of the therapeutic mechanism.
INFLUENCE OF E-PROCUREMENT IMPLEMENTATION ON SUPPLY CHAIN PERFORMANCE IN DAIRY INDUSTRY IN KENYA: A CASE OF NEW KCC LIMITED

E-procurement is gaining popularity in today’s competitive business world. Businesses using eprocurement benefit have from shorter lead times, cost reduction, improved quality collaboration, flexibility in the supply chain among others. The purpose of the study was to examine the influence of eprocurement on supply chain performance in dairy industry in Kenya with respect to New KCC. The study adopted descriptive research design. The target population was 1500 employees working in New KCC Limited from all levels of management. The study used stratified sampling technique to come up with 150 participants. A structured questionnaire was used as data collection method. Data analysis was done using qualitative and quantitative analysis methods with the help of Statistics Package for Social Science (SPSS). Regression analysis was used to test the relationship between the independent variable (ERP, Electronic Order processing, and information sharing and supplier appraisal) and supply chain performance. The study established that there is a positive correlation between dependent variable; supply chain performance and independent variables; ERP, E-order Processing, information sharing and Esupplier appraisal. The study concludes that ERP, E-order Processing, information sharing and Esupplier appraisal influences supply chain performance to a great extent. The study recommends that organization should pay attention on independent variable if supply chain performance has to improve.
Delusion of Pregnancy – Case Series of Seven Patients

Aim: The delusion of pregnancy involves neurophysiologic, endocrine, and traditional psychodynamic factors. This study investigated these factors in seven female patients with pregnancy delusions who were treated at the psychiatric ward within a period of 4 months. Methods: Six patients were treated for schizophrenia (and two also for epilepsy) and one for organic psychosis. Medical history and clinical data were noted. Actual pregnancy was excluded. Prolactin levels in the blood were measured and records were maintained of patient therapy sessions. Results: The delusion of pregnancy was more prevalent in psychiatric practice than previously thought. Hyperprolactinemia was identified as a possible biological cause of this condition in five of the patients. Case Report Sisek-Sprem et al.; IJMPCR, 3(3): 57-63, 2015; Article no.IJMPCR. 2015.036 58 Conclusion: An integrative approach that considers psychodynamic and sociocultural factors must be adopted for etiological studies on the delusion of pregnancy, while individual differences must also be examined.
S 2 Updating Pipeline Data : Supplementary Methods And Results S 2 . 1 Updating Pipeline Data with New Pharmaprojects Data Freeze

Informa Pharmaprojects [1] data were obtained from an XML file of the full database from Jan 25, 2018. Following Nelson et al., we excluded drugs with nonhuman or xMHC gene targets. We considered xMHC to include HIST1H2AA and KIFC1 and all genes between them (Chromosome 6 25.7 Mb-33.4 Mb). We also excluded drugs with non protein-coding gene targets. All Entrez ids were mapped to ensembl ids and indications to MeSH headings. Unmapped indications and gene targets were excluded. The drug table was collapsed to one row per gene target-MeSH pair. The latest phase of gene target-MeSH pair (g,m) is defined to be the latest phase of any indication mapping to MeSH heading m over all drugs with target g. (g,m) is US-EU approved if there exists a drug d satisfying d is US/EU approved, d is approved for an indication mapping to MeSH heading m, and d has target g.
The Role of Internet Addiction and Basic Psychological Needs in Explaining the Academic Procrastination Behavior of Adolescents

DOI: 10.14812/cufej.544325 This study focuses on examining how the academic procrastination behavior of adolescents is explained through Internet addiction and basic psychological needs. The study was conducted on 493 female and 421 male participants, a total of 914 students, studying in different types of high schools in Istanbul, Turkey. The Pearson ProductMoment Correlation Coefficient and Path Analysis were used in the data analysis. According to the findings, the academic procrastination behavior of adolescents has medium level, positive and significant relationships with their Internet addiction levels. It also has weak level, negative and significant relationships with competence, relatedness and autonomy needs, which are sub-dimensions of basic psychological needs. It was observed that Internet addiction levels and the need for competence directly and significantly, and needs for autonomy and relatedness indirectly explain the academic procrastination behavior of adolescents. In addition, it was found that Internet addiction directly, negatively and significantly affects basic psychological needs, and indirectly accounts for the academic procrastination behavior of adolescents through basic psychological needs. Article history: Received Revised Accepted 06.03. 2019 12.06. 2019 21.08. 2019
Factors Influencing Teachers’ Innovative Behaviour: A Systematic Review

The rapid changes in 21st century of education system demand innovation actions from all teachers. The innovative behaviour is vital to ensure that education system remains relevant to current developments and trends. However, it has a lack of comprehensive identifications of its factors that can influence a teacher’s innovative behaviour, especially in recent decades. This study employed a Systematic Literature Review (SLR) as a research method. The SLR consists of review protocol which specifies the topic to be researched and the method customized in conducting the review. It is the main strategy of detecting relevant literature review and how information is obtained from the primary study. Planning, conducting, and reporting the review are phases of the SLR method. The study found that leadership and self-efficacy are the most dominant factors in influencing teachers’ innovative behaviour in the school sector. Detailed empirical studies need to be done to see whether leadership and self-efficacy factors influence the teachers’ innovative behaviour directly or indirectly as potential mediator and moderators. The research can be improved by filtering articles in foreign languages, using a more extensive database and exploring other factors through in-depth interviews. It is recommended that the identified factors be used in different settings and also focusing on non-dominant factors.
INCOME, CHARITABLE GIVING, AND PERCEPTION BIAS

This paper analyses income and charitable giving from the perspective of perception bias. We show that perception bias affects charitable giving through its effects on warm glow, while inequality aversion counteracts these effects. Donors’ perception bias regarding a recipient’s situation does not necessarily decrease their charitable giving. Specifically, perception bias regarding the recipients’ effort and life shock decreases donors’ charitable giving. Perception bias regarding the recipients’ ability decreases donors’ giving to charities designed to help low-ability recipients but increases their giving to charities designed to help high-ability recipients. We also show that perception bias increases with donors’ income. Fundraising professionals shall allocate more efforts to those who do not care about inequality that much when correcting the donors’ perception bias; focus their efforts on correcting the donors’ perception bias, especially for rich donors, when raising money for charities with low-ability recipients; but increase donors’ perception bias regarding the recipients’ ability when raising money for charities with high-ability recipients.
Per-Host DDoS Mitigation by Direct-Control Reinforcement Learning

DDoS attacks plague the availability of online services today, yet like many cybersecurity problems are evolving and non-stationary. Normal and attack patterns shift as new protocols and applications are introduced, further compounded by burstiness and seasonal variation. Accordingly, it is difficult to apply machine learning-based techniques and defences in practice. Reinforcement learning (RL) may overcome this detection problem for DDoS attacks by managing and monitoring consequences; an agent’s role is to learn to optimise performance criteria (which are always available) in an online manner. We advance the state-of-the-art in RL-based DDoS mitigation by introducing two agent classes designed to act on a per-flow basis, in a protocol-agnostic manner for any network topology. This is supported by an in-depth investigation of feature suitability and empirical evaluation. Our results show the existence of flow features with high predictive power for different traffic classes, when used as a basis for feedback-loop-like control. We show that the new RL agent models can offer a significant increase in goodput of legitimate TCP traffic for many choices of host density.
Increasing atmospheric [CO2] from glacial through future levels affects drought tolerance via impacts on leaves, xylem and their integrated function

• Changes in atmospheric carbon dioxide concentration ([CO2]) affect plant carbon/water trade-offs, with implications for drought tolerance. Leaf-level studies often indicate that drought tolerance may increase with rising [CO2], but integrated leaf and xylem responses are not well understood in this respect. In addition, the influence of low [CO2] of the last glacial period on drought tolerance and xylem properties is not well understood.
End-to-End Learning of One Objective Function to Represent Multiple Styles for Neural Style Transfer

We propose a novel architecture trained end-to-end for neural style transfer for multiple images. The architecture composes of two neural networks: an Image Transformation Network which transforms the content image into the stylized pastiche; and a proposed Normalization Network which produces unique instance normalization parameters for styles to be fed into the Image Transformation Network. The addition of a Normalization Network allows the style image to be varied over training and hence makes it an arbitrary variable. The network is successfully able to represent multiple unique artistic styles and, as suggested from an experiment using a large dataset of style images, arbitrary style transfer may be possible.
Limited Stock Market Participation and Conditional Consumption Asset Pricing

Conditional consumption asset pricing has had limited success empirically the implied risk aversion ranges from -3000 to 2000 in Nagel and Singleton (2011) and -250 to 600 in Roussanov (2014). We develop an equilibrium model where heterogeneous investors optimally choose to exit or enter the market. Non-financial income in conjunction with a constraint gives rise to state-dependent market participation, resulting in limited risk-sharing among remaining shareholders and hence a reasonable required price of risk. Our model also shows why previous empirical tests assuming full market participation can imply large or even negative risk aversion. We conduct an empirical test of our theory using the Consumer Expenditure data. Our conditional test shows that only a reasonable boundary of risk aversion (e.g., 4 to 40) is enough to explain the dynamic of equity premium. JEL Classification: G11, G12, G17
Satisfaction Guaranteed in Spouse Selection: The Dynamics of Gender and Intergenerational Relations in a Chinese Dating Reality Show

This study examines a popular TV show about heterosexual dating in contemporary China, entitled Chinese Dating. This television show provides an ongoing social forum on self-articulations of gender identities and intergenerational interactions regarding dating and spouse selection expectations of the participants. Using grounded theory to guide the data analysis, the findings about the gendered differences of spouse-selection criteria in contemporary China denote deep social and cultural expectations for young men and women in a rapidly changing China. The findings about the negotiation process of the two generations indicate the continuing cultural influence of filial piety, which provides a contrasting understanding for Western readers who have long held individual rights and decision-making as a top priority in spouse-selection. Finally, this study presents a variant of the modernization theory, which argues that industrialization and modernization result in individualism that increases the power of the young and decreases influence of the aged. INDEX WORDS: Spouse-selection criteria, Gender, Intergenerational relations, Chinese Dating TV
Firm R&D Strategies Impact of Corporate Governance

Reporting a positive relationship between institutional ownership on one hand and capital expenditures and research and development (R&D) activity on the other, Wahal and McConnell (2000) conclude that powerful investors do not drive managers to behave myopically. We provide complementary evidence by relating managerial power (lower shareholder rights) to R&D investment decisions. We argue that managerial risk aversion may incentivize more powerful managers to underinvest in long-term --and potentially risky-projects with negative consequences for corporate value. Our evidence suggests that firms with higher managerial entrenchment behave relatively more myopically than those with greater shareholder power. For a sample of 5173 US firms, results indicate that there exists a significant negative relation between managerial entrenchment --proxied by Gompers et al (2003) governance indexand propensity to undertake in-house R&D, as well as, R&D investment levels. Further, firms with more entrenched management undertake less risk.
The Influence of Telecommuting Systems, Self-Efficacy and the Quality of Management on Work Productivity and the Competitiveness of Organizational Perspectives in Multinational Companies in Jakarta, Indonesia

This study aimed to analyze the influence of telecommuting system, self-efficacy and the perspective of quality management on work productivity. It also examined the influence of telecommuting system, self-efficacy and quality management perspective on organizational competitiveness perspective, as well as to analyze the influence of labor productivity to organizational competitiveness perspective. The data was not merely collected by using questionnaires, but also field survey in various multinational companies that implemented telecommuting systems in Jakarta. The unit analysis of this study was the remote workers or commonly known as telecommuter of multinational companies in Jakarta, the Capital City of Indonesia. The number of sample surveyed was 193 employees. The data was then analyzed using SEM (Structural Equation Modeling). The study found that self-efficacy has no significant influence on work productivity and organizational competitiveness perspective. Whilst telecommuting system and the quality of management perspective have significant influenced on work productivity and organizational competitiveness perspective. Also, it was found that labor productivity has significant influenced on organizational competitiveness perspective. Therefore, those variables that have significant influenced on work productivity and organizational competitiveness perspective need to be given attention in improving the economic activities of the multinational companies in Jakarta. Index Terms Telecommuting systems, Self-Efficacy, Work Productivity, organizational competitiveness perspective and the quality of management perspective
e0383 Baseline characteristics of myocardial infarction secondary prevention study in traditional Chinese Medicine (MISPS-TCM)

Objective To evaluate Qishenyiqi Dripping Pills (QSYQ) on the efficacy of secondary prevention of myocardial infarction, improvement the evaluation system of coronary heart disease in traditional Chinese medicine (TCM), and to further establish the research methods and corresponding technical specifications of evidence-based medicine in TCM. Method MISPS-TCM, (a multicenter, large sample, central randomised system, double-blinded, double dummy and positive drug) controlled parallel trials conducted at 18 centers and 88 hospitals in China, which enrolled patients aged 75 years or younger with a history of AMI between 28 days to 2 years, and complicated with syndromes of Qi-deficiency and blood-stasis. The sample size estimated to be 3600 patients were randomly divided into two groups according to the ratio of 1:1, the treatment group taking QSYQ and aspirin simulation, and the control group taking aspirin and QSYQ simulation for 18 months. The primary endpoint was non-fatal reinfarction or stroke, or cardiac death, combined with angina pectoris and TCM symptom scores and the Seattle Angina Questionnaire. Results From November 20, 2005 to October 16, 2008, 3505 patients with AMI were entered into the study: 1746 were assigned to QSYQ, and 1759 were assigned to aspirin. Final follow-up visits were conducted on April 20, 2010. The study had 2451 men (69.9%). The mean age was 58.3 (SD: 9.0). The mean duration was 9.5 months (SD: 7.2). Disease history: 44% patients had hypertension, 39% had hyperlipidaemia, 13% had diabetes, 12% had gastritis and so on. Drug treatment history: 80% were taking anti-platelet drugs, 72% taking nitrates, withβ receptor blocking 45%, cholesterol lowering agents present in 41%, ACEI/ARB 38% and so on. The male ratio, height, smoking and drinking in QSYQ group were slightly lower than in aspirin, however, the other baseline characteristics bore no difference between the two groups, such as demographic information, diagnosis history, medication history, risk factors, angina and TCM symptom scores and the Seattle Angina Questionnaire. Conclusion Baseline characteristics were well balanced between the two groups that for further analysis and evaluation.