Miracle-dz/UniFAR-FTUs huggingface dataset:
An Asymptomatic, Ectopic Mass as a Presentation of Adrenocortical Carcinoma Due to a Novel Germline TP53 p.Phe338Leu Tetramerisation Domain Variant

Adrenocortical carcinoma (ACC) is a rare cancer in childhood. ACC is frequently associated with germline TP53 variants, with founder effects especially due to the p.Arg337His mutation. ACC leads to the secretion of adrenocortical hormones, resulting in endocrine syndromes, which is the usual trigger for establishing the diagnosis. We present a surprising ACC pathology in a non-secreting, ectopic retroperitoneal tumour in a 4-year-old boy, successfully controlled with chemotherapy and mitotane after microscopically incomplete tumour resection with spillage. Genomic analysis (gene panel sequencing and copy-number microarray) demonstrated a novel p.Phe338Leu tetramerisation domain (TD) TP53 variant in the proband and his cancer-free mother and a monoallelic deletion encompassing the TP53 locus in cancer tissue, consistent with cancer-predisposition syndrome. While the recurrent p.Arg337His variant translates into high ACC risk, residue 338 and, in general, TD domain variants drive heterogeneous clinical scenarios, despite generally being considered less disruptive than TP53 DNA-binding domain mutations.
Delving the Role of the Ameliorative Effects
of Caralluma tuberculata N.E.Br. (Apocynaceae)
on Diabetes and Its Effect on the Organs Weight
of Alloxan-Induced Adult Male Mice

Caralluma tuberculata N.E. Br. is a naturally occurring plant that has been used for thousands of years for its health benefits. In the present study, the blood sugar lowering effect of C. tuberculata was investigated and compare with that of the diabetes drug metformin. The lyophilized extract of C. tuberculata was administered given to both non-diabetic and diabetic mice. Sixty mice were randomly divided into six groups. Blood glucose levels were measured after 24, 48, 72, and 96 h. The dose was administered orally after being dissolved in maize oil. Analysis of variance (ANOVA) and Tukey’s post hoc test of SPSS were used to determine and compare the hypoglycemic effects of C. tuberculata extract and metformin at different time intervals. In diabetic mice administered C. tuberculata extract at a dosage of 200 mg/kg body weight, there was a significant ( p <0.001) decrease in mean blood glucose level and a protective effect on organ weight. When the effects of the drug metformin (150 mg/kg
COVID-19 Vaccine Knowledge, Attitude, Acceptance and Hesitancy among Pregnancy and Breastfeeding: Systematic Review of Hospital-Based Studies

The risk of unfavourable outcomes for SARS-CoV-2 infection is significant during pregnancy and breastfeeding. Vaccination is a safe and effective measure to lower this risk. This study aims at reviewing the literature concerning the anti-SARS-CoV-2 vaccine’s acceptance/hesitancy among pregnant and breastfeeding women attending hospital facilities. A systematic review of literature was carried out. Hospital-based observational studies related to vaccination acceptance, hesitancy, knowledge and attitude among pregnant and breastfeeding women were included. Determinants of acceptance and hesitancy were investigated in detail. Quality assessment was done via the Johann Briggs Institute quality assessment tools. After literature search, 43 studies were included, 30 of which only focused on pregnant women (total sample 25,862 subjects). Sample size ranged from 109 to 7017 people. Acceptance of the SARS-CoV-2 vaccine ranged from 16% to 78.52%; vaccine hesitancy ranged between 91.4% and 24.5%. Fear of adverse events for either the woman, the child, or both, was the main driver for hesitancy. Other determinants of hesitancy included religious concerns, socioeconomic factors, inadequate information regarding the vaccine and lack of trust towards institutions. SARS-CoV-2 vaccine hesitancy in hospitalized pregnant women appears to be significant, and efforts for a more effective communication to these subjects are required.
The effect of Al/Si disorder on the bulk moduli of plagioclase feldspars

Abstract The volumes of a disordered An20 (Qod = 0.15), a disordered An78 (Qod = 0.55) and an ordered An78 (Qod = 0.81) were determined up to 9.569(10) GPa, 8.693(5) GPa and 9.765(10) GPa, respectively, using single-crystal X-ray diffraction. The volume variations with pressure for these samples are described with 4th-order Birch Murnaghan equations of state with V0 = 669.88(7) Å3, K0 = 59.7(7) GPa, K’ = 5.7(5), K’’ =−0.8(2) GPa−1 for disordered An20, V0 = 1340.48(10) Å3, K0 = 77.6(5) GPa, K0’ = 4.0(3), K’’ = −0.59(9) GPa−1 for disordered An78 and V0 = 1339.62(6) Å3, K0 = 77.4(6) GPa, K’ = 4.2(4), and K’’ = −0.7(1) GPa−1 for ordered An78. Along with data from previous studies (An0 ordered, An0 disordered and An20 ordered), the volumes for the disordered samples were found to be up to ~0.3% larger than the ordered samples of the same composition. The disordered samples are softer than the ordered samples of the same composition by 4(1)% for An0, 2.5(9)% for An20 and essentially zero for An78. The relationship between volume increase, density decrease, and decreasing bulk modulus with increasing disorder is in accordance with Birch’s Law.
Influence of the Leadership Style on Information Transfer and Corporate Culture to Boost Employee Efficiency in Bantaeng Regency

This study aims to analyse the impact of infrastructure and supervision on employee performance and the quality of public service and investigate the effect of employee performance on the quality of public services. Analyse the impact of infrastructure and supervision on public services quality through employees' performance in sub-districts in Bantaeng, Bantaeng Regency. This type of analysis is a descriptive quantitative study with a sample of 96 employees using field research and literature data collection techniques. The interpretation of the data used is route analysis (Path Analysis). This study's findings show that infrastructure and supervision have a positive and significant effect on the efficiency of employees themselves in the sub-district of Bantaeng. Bantaeng district, facilities, and infrastructure have a positive and significant impact on the quality of public services in the sub-district of Bantaeng district, Bantaeng Regency. Public services in the Bantaeng District Sub-district, Bantaeng District, staff performance has a positive and significant effect on the quality of public services in the Bantaeng District Subdistrict. Facilities and monitoring have a positive and significant impact on the quality of public services through staff performance in the Bantaeng Sub-district.
The Influence of Elderly Posyandu Management on Health and Quality of Life at the Sinoa Community Health Center in Bantaeng

Background: The Elderly Posyandu (integrated healthcare center) at the Sinoa Community Health Center in Bantaeng has an important role in maintaining the quality of life of the elderly in the community. Apart from providing health services, this smallest service unit will also facilitate various non-medical activities so that the elderly have a place to work and be active. Purpose: This is the researchers' idea to examine whether there is an influence of the Elderly Posyandu program on the quality of life of the elderly in the Sinoa sub-district, Bantaeng. Methods: This study used a quantitative method with a cross-sectional design. The population of this study was 210 elderly with a total sample of 136 elderly selected by means of proportional stratified random sampling. Data collection was carried out by means of interviews using a questionnaire. The collected data were analyzed using the path analysis test. Results: Results of path analysis, where the independent variable (predictor) is the Elderly Posyandu variable include extension (X1) and elderly gymnastics (X2), the mediation variable is the elderly health (Y), and the dependent variable (response) is the quality of life of the elderly (Z), show that periodic medical check-up (X3) through the elderly health variable (Y) has the greatest indirect influence on the quality of life of the elderly in the Sinoa sub-district, Bantaeng. Conclusion: Posyandu management for the elderly is very important because it will affect the quality of life of the elderly. The management in question includes the elderly Posyandu program.
Deep Learning-Based Standard Sign Language Discrimination

General sign language recognition models are only designed for recognizing categories, i.e., such models do not discriminate standard and nonstandard sign language actions made by learners. It is inadequate to use in a sign language education software. To address this issue, this paper proposed a sign language category and standardization correctness discrimination model for sign language education. The proposed model is implemented with a hand detection and standard sign language discrimination method. For hand detection, the proposed method utilizes flow-guided features and acquires relevant proposals using stable and flow key frame detections. This model can resolve the inconsistency between the forward optical flow and the box center point offset. In addition, the proposed method employs an encoder-decoder model structure for sign language correctness discrimination. The encoder model combines 3D convolution and 2D deformable convolution results with residual structures, and it implements a sequence attention mechanism. A Sign Language Correctness Discrimination dataset (SLCD dataset) was also constructed in this study. In this dataset, each sign language video has two recognition labels, i.e., sign language category and standardization category. The semi-supervised learning method was employed to generate pseudo hand position labels. The hand detection model was getting sufficiently high hand detection result. The sign language correctness discrimination model was tested with hand patches or full images. SLCD dataset is available at https://dx.doi. org/10.21227/p9sn-dz70.
SOCIAL AND RECREATIONAL TRAVEL: THE DESTINATIONS, TRAVEL MODES AND CO2 EMISSIONS OF NEW ZEALAND HOUSEHOLDS

Road transport has been a major contributor to New Zealand’s increasing rate of CO2 emissions over the past 15 years. New Zealand Travel Survey (NZTS) data show that 29% of the kilometres travelled by households are for social and recreational purposes. These trips are less amenable to the travel demand management strategies applied in work and school settings (such as increasing public transport, parking restrictions and travel plans) because they occur at all times of the day and all days of the week, and trips are taken to an unlimited number of destinations. To understand the characteristics of social and recreational travel, an analysis of the destinations of the 18,299 social and recreational trips recorded in the 2003−2006 NZTS was undertaken. Transport mode use for the most common trip destinations was compared and differences in trip patterns by gender, age, ethnicity and neighbourhood deprivation were examined. It was found that trips to visit family and friends and recreational trips to open spaces such as beaches, lakes and parks are the most common destination categories and those least often made on foot. The potential and limitations of virtual mobility and urban design to reduce CO2 emissions from household social and recreational travel are discussed. BACKGROUND
Factors Associated with High Rates of Caesarean Deliveries: A Cross Sectional Study Classifying Deliveries According to Robson in Mengo Hospital Kampala

Introduction The number of caesarean section (CS) continues to rise worldwide. CS can improve outcomes in infants and mothers. However, if used improperly, the potential harm can outweigh the potential benefits. Aim The study was to determine the factors associated with high cesarean section rates at Mengo Hospital. Methods This cross-sectional study used a mixed-method approach that included a retrospective review of 1276 casebooks using the Robson Ten Group Classification System (RTGCS) for births that occurred at Mengo Hospital in December 2018, January, and February 2019. Questionnaire was used for data collection from 200 mothers on second day after birth from 24th May to 19th July 2019. Eight key informants were interviewed within the same period. Quantitative data were analyzed using STATA V.14, thematic analysis for qualitative data. Univariate, bivariate, and multivariate analyses were performed to determine the association between predisposing factors and outcome variables using chi-square and modified Poisson. Results Caesarean section rate (CSR) from casebooks was 49% and 64% from the primary data. Group 5(Previous CS, single cephalic, >37 weeks) had (35.4%) to the total number of cesarean deliveries, followed by Group 1 (Nulliparous, single cesarean deliveries, >37 weeks in spontaneous labour), with 18.4%. Group 3 (ultiparous (excluding previous CS), single cephalic, >37 weeks of spontaneous labor) with (13.7%). The common indications from casebooks were a previous scar (32%), obstructed labor (18%), and previous scar (97.6%). Presence of an obstetric indication, influence of husband, friends, relatives, and mother’s desire for a CS were closely associated with caesarean delivery. Mothers said that occurrence of CS was due to health workers reducing the stress of monitoring labour and financial benefits from CS deliveries by the hospital. Conclusion Repeat CS made the highest CSR contribution; therefore, strategies to reduce the frequency of the procedure should include avoiding medically unnecessary primary CS and encouraging vaginal birth after previous CS where applicable.
Generation of overpressure by cementation of pore space in sedimentary rocks

SUMMARY Overpressure build-up is studied when the main cause for porosity reduction is cementation of the pore space sourced locally. The average porosity reduction for siliclastic sediments is modelled with nth-order kinetics. It is shown that the overpressure in one layer at a constant depth will decrease exponentially with time in the case of first-order kinetics for the porosity reduction. The overpressure is studied in one layer subjected to cementation during constant burial along a thermal gradient. A small overpressure build-up is shown above the window for cementation, with a steep rise in overpressure in the upper part of the window. The overpressure build-up is then seen to decrease rapidly towards the end of the window for cementation. Overpressure build-up is also studied when cementation is the main cause for porosity reduction in the entire column of sediments during deposition and burial. The overpressure regime characterized by gravity numbers larger than one is studied. This regime corresponds to low or moderate overpressures in the case of mechanical compaction. Cementation is shown to imply a steep pressure build-up in the window of cementation, which will easily exceed the lithostatic pressure. The porosity loss due to cementation is seen to have a strong impact on the permeability, which leads to the formation of a pressure seal. Although most of the potential for fluid expulsion is exhausted below the seal, because most of the porosity is cemented up, the permeability of the seal is sufficiently low for hydrofracturing to take place. This scenario is consistent with overpressure observations in many wells.
Potassium and calcium content in padelegan water which is used as the raw water for making salt

Potassium and calcium are elements contained in seawater. The presence of potassium and calcium in raw saltwater were impurities in producing non-food salt. On the other hand, potassium and calcium as target minerals are desirable in mineral-rich healthy salt (food salt) production. Information about the potassium and calcium content in raw salt water can assist in analyzing the quality of the salt to be produced. The purposes of this study were; to determine the content of potassium, and calcium in Padelegan waters used as a source of salt raw materials, compare them with other locations, and their correlation with water quality. The potassium and calcium content in the sample were determine used the AAS (Atomic Absorption Spectrophotometry) method. Potassium concentrations ranged from 221,870 to 285,110 mg/L, and those for calcium from 497,700 to 552,713 mg/L. The potassium content in Padelegan waters is smallest than other reference waters. In contrast, the calcium content in Padelegan waters is greatest than in other reference waters.
Start-up Dynamics of Vertical Axis Wind Turbines: A Review

Vertical Axis Wind Turbines (VAWTs) are becoming increasingly popular for wind power extraction due to their simpler design, lower manufacturing and maintenance costs. The omni-directionality of these power generating machines make them more suitable for operation both under lower wind speeds and highly transient winds. The key wind power extraction component of VAWTs is their rotor, which is conventionally either Drag-based or Lift-based, with the latter being more widely studied in the published literature due to its higher power coefficient compared to its counterpart. The lift-based rotor comprises of aerodynamically profiled blades, while the drag-based rotor comprises of thin cup-shaped blades. The start-up of both these types of VAWT rotors has been an area of active research in the last decade. These studies have been conducted using numerical and experimental methods focusing on key parameters related to the start-up dynamics of VAWTs. Many of these research studies complement each other’s findings, however, there are also a number of aspects where there are disagreements and/or significant knowledge gaps that need to be highlighted in order to accelerate scientific efforts strategically. In the present study, we aim to address these challenges through a thorough and critical review of the published literature on VAWTs’ start-up dynamics, leading towards the identification of key knowledge gaps.
Recommendations of the Brazilian College of Radiology, the Brazilian Society of Mastology and the Brazilian Federation of Gynecology and Obstetrics Associations for breast cancer screening in Brazil

Objective: To present the updated recommendations of the Brazilian College of Radiology and Imaging Diagnosis, the Brazilian Society of Mastology and the Brazilian Federation of Gynecology and Obstetrics Associations for breast cancer screening in Brazil. Methods: Between January 2012 and July 2022, searches for scientific evidence published in MEDLINE, Embase, Cochrane Library, EBSCO, CINAHL and LILACS were carried out. The recommendations were based on this evidence, with the consensus of a committee of experts from the three institutions. Recommendations: The annual mammography screening is recommended for normal-risk patients aged between 40 and 74 years. For women aged more than 75 years, it is reserved for those whose life expectancy is longer than seven years. Women whose risk is higher than normal, such as those with dense breasts, personal history of atypical lobular hyperplasia, classic in situ lobular carcinoma, atypical ductal hyperplasia, women undergoing breast cancer treatment or thoracic irradiation before the age of 30, or those with genetic mutation or strong family history, benefit from complementary screening, being considered in an individual manner. Tomosynthesis is an evolution of mammography and should be considered in screening whenever accessible and available.
Design, synthesis, and antimicrobial evaluation of new antipyrine derivatives bearing thiazolopyridazine and pyrazolothiazole scaffolds

Abstract In the current research, a new set of antipyrine–thiazole hybrids were designed and synthesized and screened for their antimicrobial activities against Gram-positive and Gram-negative bacteria and fungal strains using ciprofloxacin and nystatin as reference drugs. The antipyrine derivatives 3a, 5a, 7c, and 11a revealed promising and broad antibacterial activity especially against S. aureus, followed by in vitro enzyme inhibitory assay against S. aureus DNA gyrase to predict the mechanism of action. The thiazole 3a and pyrazolo[4,3-d]thiazole 7c afforded superior inhibitory activity against S. aureus DNA gyrase (IC50 = 0.292 ± 0.15 and 0.255 ± 0.10 µM, respectively) in comparison with ciprofloxacin (IC50 = 0.331 ± 0.20 µM). Finally, the in silico molecular docking and ADME studies were established to give better rationalization and optimization of efficient new antimicrobial leads. Graphical Abstract
Uso do clorofilômetro no monitoramento nutricional de arroz irrigado com vistas ao manejo da adubação nitrogenada

Chlorophyll meter can help in the management of topdressing nitrogen fertilization, however, there isn't a critical reading value with a satisfactory relationship with grain yield. The objective of this study was to monitor the nitrogen (N) level in flooded rice plants, cultivars IRGA 422CL and IRGA 424, using the chlorophyll meter and associating the readings with green/dry matter production and grain yield. Two experiments were carried out in the crop years 2007/08 and 2008/09 with N rates for the 1st and 2nd topdressing fertilizations, followed by SPAD (Soil Plant Analysis Development) readings and determination of green/dry mater, N content in plant tissue, accumulated N and grain yield. It was found effect of the 1st and 2nd N applications on chlorophyll meter readings along the cycle, however, the SPAD readings became similar with time for all treatments. Green/dry matter production and accumulated N responded linearly to the N rates. There was no effect of interaction for N rates and grain yield, but the response of grain yield as a function of N rates was described by a quadratic equation in both experiments. SPAD readings evaluated the nutritional status of flooded rice plants but did not show accurate information about N needs with reflexes in the yield. Therefore, chlorophyll meter readings could be associated to other parameters, such as green/dry mater to help interpretation and adjustment of N topdressing fertilization.
Endovascular Embolization for Epistaxis: A Single Center Experience and Meta-Analysis

The optimal treatment for intractable epistaxis is still controversial. Various studies have demonstrated high success rates and low complication rates for endovascular embolization. Herein, the authors report an institutional experience and meta-analysis in terms of efficacy and safety of endovascular embolization of intractable epistaxis. This was a retrospective observational study of 35 patients with epistaxis who underwent 40 embolization procedures between 2010 and 2023. The primary outcome was immediate success defined by immediate cessation of epistaxis at the end of the procedure. Immediate success was achieved in most of the procedures (39, 97.5%). During follow-up, three (7.5%) patients experienced a rebleed. Forty-one studies from 3595 articles were identified for inclusion in the meta-analysis and comprised 1632 patients. The mean pooled age was 57.5 years (95% CI: 57.2–57.8) and most patients were males (mean: 70.4, 95% CI: 69.8–71.0). Immediate success was achieved at a pooled mean of 90.9% (95% CI: 90.4–91.4) and rebleeding was observed at a pooled mean of 17% (95% CI: 16.5–17.5). In conclusion, endovascular embolization proved to be both safe and effective in treating intractable epistaxis carrying a low risk of post-operative stroke.