Miracle-dz/UniFAR-FTUs huggingface dataset:
Improving Limited Labeled Dialogue State Tracking with Self-Supervision

Existing dialogue state tracking (DST) models require plenty of labeled data. However, collecting high-quality labels is costly, especially when the number of domains increases. In this paper, we address a practical DST problem that is rarely discussed, i.e., learning efficiently with limited labeled data. We present and investigate two self-supervised objectives: preserving latent consistency and modeling conversational behavior. We encourage a DST model to have consistent latent distributions given a perturbed input, making it more robust to an unseen scenario. We also add an auxiliary utterance generation task, modeling a potential correlation between conversational behavior and dialogue states. The experimental results show that our proposed self-supervised signals can improve joint goal accuracy by 8.95% when only 1% labeled data is used on the MultiWOZ dataset. We can achieve an additional 1.76% improvement if some unlabeled data is jointly trained as semi-supervised learning. We analyze and visualize how our proposed self-supervised signals help the DST task and hope to stimulate future data-efficient DST research.
Characterization of Antimicrobial Susceptibility, Extended-Spectrum β-Lactamase Genes and Phylogenetic Groups of Enteropathogenic Escherichia coli Isolated from Patients with Diarrhea

Objectives Infectious diarrhea is one of the most common causes of pediatric death worldwide and enteropathogenic Escherichia coli (EPEC) is one of the main causes. There are 2 subgroups of EPEC, typical and atypical, based on the presence or absence of bundle forming pili (bfp), of which atypical EPEC is considered less virulent, but not less pathogenic. Antimicrobial resistance towards atypical EPEC among children is growing and is considered a major problem. In this study the pattern of antibiotic resistance in clinical isolates was determined. Methods Using 130 isolates, antibiotic resistance patterns and phenotypes were assessed, and genotypic profiles of extended spectrum β-lactamase (ESBL) production using disc diffusion and PCR was carried out. Phylogenetic groups were analyzed using quadruplex PCR. Results There were 65 E. coli isolates identified as atypical EPEC by PCR, among which the highest antibiotic resistance was towards ampicillin, followed by trimethoprim-sulfamethoxazole, and tetracycline. Multidrug resistance was detected in 44.6% of atypical EPEC isolates. Around 33% of isolates were determined to be extended spectrum β-lactamase producers, and in 90% of isolates, genes responsible for ESBL production could be detected. Moreover, the majority of atypical EPEC strains belonged to Group E, followed by Groups B1, B2 and C. Conclusion High rates of multidrug resistance and ESBL production among atypical EPEC isolates warrant periodical surveillance studies to select effective antibiotic treatment for patients. It is considered a critical step to manage antibiotic resistance by avoiding unnecessary prescriptions for antibiotics.
An Evaluation of the Video Narrative Technique on the Self-Efficacy of Medication Understanding and Use Among Post-Stroke Patients: A Randomized-Controlled Trial

Introduction Self-efficacy is positively associated with medication understanding and use self-efficacy (MUSE) among post-stroke patients. It is also closely related to knowledge, belief, and perception, which vary among people from different socioeconomic backgrounds and cultures. As interventions using video and peer stories have emerged to be successful on behavior modification, this study aimed to explore the effectiveness of video narratives incorporated with Health Belief constructs on MUSE and its associated factors among patients with stroke at a local setting. Methods A randomized controlled trial (RCT) for 12 months was carried out on patients diagnosed with stroke at Hospital Kuala Lumpur, Malaysia. The RCT recruited up to 216 eligible patients who were requested to return for two more follow-ups within six months. Consented patients were randomized to either standard care or intervention with video narratives. The control of potential confounding factors was ensured, as well as unbiased treatment review with prescribed medications, only obtained onsite. Results and Discussion A repeated measure of MUSE mean score differences at T0 (baseline), T2 (6th month) and T4 (12th month) for antithrombotic, antihypertensive, and all medication categories indicated significant within and between groups differences in the intervention group (p<0.05). Moreover, this impact was reflected upon continuous blood pressure (BP) monitoring compared to the control group (F (1214) =5.23, p=0.023, ƞ2=0.024). Though BP measure differences were non-significant between the groups (p=0.552), repeated measure analysis displayed significant mean differences between intervention and control group on BP control over time (F (1.344, 287.55) =8.54, P<0.001, ƞ2=0.038). Similarly, the intervention’s positive impact was also present with similar trends for knowledge, illness perception, and the belief about medicine. Though significant differences (p<0.05) of all outcome measures gradually decreased between T2 and T4 in the intervention group; nevertheless, these positive findings confirmed that personalized video narratives were able to motivate and influence MUSE and its associated factors among post-stroke patients. The significant improvement in medication-taking self-efficacy and the sustenance of BP monitoring habits among patients in the intervention group strengthened our conceptual framework’s practicality.
Undiagnosed Hypertension and Associated Factors among Adult Dwellers in Hawela Tula Sub City, Hawassa, Southern Ethiopia: A Community Based Cross-sectional Study

Introduction Hypertension is a common public health problem and often goes unnoticed and can lead to a stroke or heart attack. It contributes to the high burden of cardiovascular disease, premature mortality, reduced quality of life and high costs to the health care system, especially in low and middle-income countries. Therefore, this study aimed to assess the prevalence of undiagnosed hypertension and influencing factors with health-seeking behaviour.Method A community-based cross-sectional study was conducted on 390 randomly selected adults in Hawela Tulla Sub-city, Hawassa, southern Ethiopia from February to June, 2019. Data was collected by pre-tested questionnaires and physical measurements of weight, height and blood pressure were collected through standardized procedures adapted from WHO STEPS survey tools. Data entry and analyzed for descriptive and logistic regression models by SPSS v.23. The result declared as statistically significant at p < 0.05. Result The prevalence of the undiagnosed hypertension among the respondents was 12.3%. The male [AOR= 3.70, 95% CI:1.64-8.32] than female contributing. Family history of hypertension had [AOR 3.69, 95% CI: 1.31-10.34], being physical inactive [AOR 3.21, 95% CI: 1.50- 6.84], salty food consumer [AOR 3.67, 95% CI:1.26-10.64], BMI 25 Kg/m2 and above [AOR 3.06, 95% CI:1.41-6.65] and not seek health care for some early hypertensive symptoms without serious illness [AOR 4.58, 95% CI: 1.85-11.32] when compared to their counterparts, were found to be determinant factors for undiagnosed hypertension.Conclusions and Recommendation The prevalence of undiagnosed hypertension found to be prevalent and calls for intervention. Health officials need to consider integrating the prevention and control of hypertension at the community level. The clinicians need to intervene on unhealthy lifestyles, by promoting healthy practices and health-seeking behavior to prevent undiagnosed hypertension.
Dyspnea During Night-Time and at Early Morning in Patients with Stable COPD is Associated with Supine Tidal Expiratory Flow Limitation

Rationale Patients with chronic obstructive pulmonary disorder (COPD) complain of various COPD-related symptoms with different daily frequencies. During the night-time and at early morning, dyspnea is often reported and may predict an increased risk of COPD exacerbation and hospitalization and all-cause mortality. The aim of the study was to assess the underlying mechanisms of this symptom, seeking functional biomarkers of its occurrence. Methods Stable COPD patients with moderate-to-severe airflow obstruction and without confounding comorbidities underwent extensive baseline function respiratory tests. Spirometry, maximal flow-volume curves, lung volumes, and lung diffusion capacity parameters were obtained. Inspiratory capacity was also measured both in seated and supine positions. Forced oscillation technique (FOT) and negative expiratory pressure (NEP) method were used to establish the presence of tidal expiratory flow limitation (EFL) during recumbency. Questionnaires for recording COPD-related symptoms were administered. Sleep-related disturbances reported by the patients were also registered. Results Forty-two consecutive COPD patients aged 65±9 completed the protocol. They were divided, according to the absence (NFL) or presence (FL) of supine EFL, in NFL group (n=17) and FL group (n=25). FL COPD patients had more severe airflow obstruction (FEV1= 46.4±19.4 vs 65.1±12.5% pred., p<0.01) and they showed no increase of supine IC in contrast with NFL COPD patients (ΔIC= 0.080±0.18 vs 0.390±0.28 L, p<0.01). Dyspnea either during night-time and at early morning was significantly more reported in FL COPD patients than in NFL COPD patients (p<0.05) and in those with less than 10% increase in supine IC (p<0.05). Conclusion Supine EFL is frequently associated with both night-time and early morning dyspnea, suggesting that the development of recumbent dynamic pulmonary hyperinflation, heralded by the lack of increment of IC in supine position, is a pivotal mechanism of this symptom. No or trivial increase in supine IC may indicate the occurrence of dyspnea under these conditions.
Anemia in HIV/AIDS Patients on Antiretroviral Treatment at Ayder Specialized Hospital, Mekele, Ethiopia: A Case-Control Study

Background Human immunodeficiency virus and anemia are the major public health problems in Sub-Sahara Africa. Untreated anemia is associated with rapid progression and poor prognosis of the disease in HIV. This study was aimed at determining the magnitude, severity and associated factors of anemia among HIV infected patients taking zidovudine and tenofovir-containing first-line HAART in Ayder Comprehensive Specialized Hospital, Mekele, Ethiopia. Methods A case-control study was conducted from February to August 2019 using both convenient and quota sampling methods. Anemia is defined as hemoglobin value below 13 g/dl for male and below 12 g/dl for female. Sociodemographic and clinical characteristics were assessed using a structured questionnaire, medical records, electronic weighing scale, adult height board, automated hematology analyzer (Sysmex XT-4000i), and Becton Dickinson’s FACS caliber flow cytometer. Descriptive statistics, tables, graphs, Student’s t-test and l logistic regression were used to analyze the data. Results About one-third (33.5%) of study participants were found to be anemic (ZDV: 20.3%; TDF: 13.2%, and p<0.05). Among these anemic cases, the majority was found to have mild, and the remaining was moderate types. The most common form was normocytic-normochromic anemia (46.5%). Cotrimoxazole prophylaxis, poor adherence, advanced AIDS stage at baseline and underweight at baseline were the factors associated with anemia in patients taking zidovudine-containing regimen (p<0.05). Advanced stage at baseline, cotrimoxazole prophylaxis, poor adherence status and lack of regular income were significantly associated with anemia in patients taking tenofovir-containing regimen (p<0.05). Conclusion We find that the prevalence of anemia was significantly higher among patients taking ZDV-containing regimen. But different risk factors for anemia had been identified among ZDV-containing regimen, showing that appropriate follow-up, nutritional supplementation, continuous evaluation of patients on cotrimoxazole intake can reduce the risks of anemia in both types of regimens.
Anterior Acute Uveitis Report in a SARS-CoV-2 Patient Managed with Adjunctive Topical Antiseptic Prophylaxis Preventing 2019-nCoV Spread Through the Ocular Surface Route

Purpose To report the clinical-epidemiological association between acute anterior uveitis and acute bilateral follicular conjunctivitis in a 30-year-old female patient who had tested positive for the SARS-CoV-2 RT-PCR. Methods A 30-year-old female visited emergency ophthalmology care at the Siena Crosslinking Centre, Italy, for a bilateral eye redness lasting two weeks, associated with unilateral photophobia and blurred vision in her right eye. She visited on the 23rd of March 2020 in the full pandemic period and presented chills and fever with a temperature of 39.0°C, associated with complete loss of taste. Since eye examination findings, systemic symptoms and epidemiological criteria correlated with SARS-CoV-2 infection, she was referred to Siena University Hospital, Italy, for the SARS-CoV-2 nasopharyngeal buffer and haematological examinations for uveitis. Results Eye examination revealed bilateral conjunctival hyperaemia with acute follicular conjunctivitis associated with right eye acute anterior uveitis characterized by diffuse pigmentary and whitish immune precipitates over the anterior capsule of the crystalline lens and initial anterior lens opacity explaining the blurred vision. Adjunctive prophylactic eye topical treatment, included in the acronym SHYPIO (0.02% sodium hypochlorite solution, 0.6% povidone iodine eye-drops and 10.50% ozonized oil eye-drops), was associated with conventional uveitis therapy to prevent the virus spread through the ocular surface route. Conclusion Our report demonstrates that complicated acute anterior uveitis (iridocyclitis) with blurred vision could be associated with SARS-CoV-2 infection, being potentially sight-threatening for early complicated lens opacity. Ophthalmologists examining suspected or asymptomatic patients should be aware of the risk of 2019-nCoV infection.
Determinants of Diabetic Foot Ulcer Among Adult Patients with Diabetes Attending the Diabetic Clinic in Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia: Unmatched Case–Control Study

Background Diabetic foot ulcer is among the commonest complications of diabetic mellitus attributed to a number of morbidity and mortality cases in diabetic patients. Nowadays, the incidence of diabetic foot ulcer is increasing due to the increased prevalence of diabetes. However, the risk factors of the problem are less studied in Ethiopia. Hence, this study was conducted to assess the determinants of diabetic foot ulcer among adult patients with diabetes attending a diabetic clinic in Tikur Anbessa Specialized Hospital, Addis Ababa, Ethiopia in 2019. Patients and Methods An institution-based unmatched case–control study was conducted on 161 patients with diabetes (53 patients with diabetes with foot ulcer and 108 patients with diabetes without foot ulcer). Cases were selected from patients with diabetes with foot ulcer by consecutive sampling technique and controls from patients with diabetes without diabetic foot ulcer by systematic random sampling technique. A binary logistic regression model was used to assess the association between the dependent and independent variables. All variables with a P-value<0.25 were included in the multivariable analysis. Statistical significance was declared at P-value<0.05 with 95% confidence interval. Results In this study, 28 (52.8%) cases and 55 (50.9%) controls were male. Taking insulin alone (AOR=2.75, 95% CI=1.04–7.23), having peripheral neuropathy (AOR=7.56, 95% CI=2.82–20.24), not inspecting feet daily (AOR=5.61, 95% CI=2.24–14.05), and using moisturizing cream between toes (AOR=3.35, 95% CI=1.35–8.32) were positively associated with diabetic foot ulcer, whereas employed (AOR=0.35, 95% CI=0.14–0.87) and combined treatment (insulin and oral hypoglycemic agents) (AOR=0.11, 95% CI=0.02–0.57) were negatively associated with diabetic foot ulcer. Conclusion Diabetic foot ulcer was significantly associated with occupation, kind of treatment of diabetes mellitus taking, peripheral neuropathy, inspecting feet daily, and putting moisturizing cream between toes. It will be helpful if diabetic patients inspect their feet on a daily basis and do not put moisturizing cream between their toes.
Influence of environmental factors on carpetgrass seed germination

The aim of this study was to verify the influence of temperature, light, substrate, sowing methods, and salt and water stress on carpetgrass (Axonopus affinis, in the Poaceae family) seed germination. All four trials were performed in a germination chamber under controlled conditions of temperature, moisture and photoperiod. Experimental designs were entirely randomized with 100 seeds per plot. For the study of temperature and light (Experiment 1), treatments were arranged in a 6 x 2 factorial scheme, with six temperature regimes (constant at 20, 25, 30, and 35°C, and alternate at 20 to 30 and 20 to 25°C) combined with two light conditions (light: 8 h of light and 16 h of dark, and dark: 24 h without light) and four replications. For the study of substrate and sowing methods (Experiment 2), there were four treatments (on paper, between paper, on sand, and in sand) with five replications. For the study of salt stress (Experiment 3), there were five treatments, composed of NaCl concentrations (0, 25, 50, 75 and 100 mM), with four replications. For the study of water stress, treatments were arranged in a 3 x 2 factorial scheme (Experiment 4), with three substrate water contents (50, 75 and 100% water retention capacity) and two sowing methods (on sand and in sand), and four replications. Germination percentage and rate were evaluated. It was concluded that seed germination was more effective at the alternate temperatures of 20 to 30 and 20 to 35°C, under light, sown on sand, on a paper substrate or between papers. The NaCl concentrations did not affect germination percentage; however, germination was slower as the NaCl concentration increased. Faster and higher germination occurred when seeds were sown on sand at 100% of its water retention capacity. Key words: Axonopus affinis, light, salt stress, substrate, temperature, water stress.
Foliar Applied Acetylsalicylic Acid Induced Growth and Key-Biochemical Changes in Chickpea (Cicer arietinum L.) Under Drought Stress

The exogenous application of acetylsalicylic acid (ASA) is stated to increase tolerance of plants against different environmental stresses. Therefore, the present study was planned to get insight into ASA-mediated regulation of growth, secondary metabolism, and oxidative defense in 2 chickpea varieties. Ten seeds of 2 chickpea varieties (DG-89 and Bittle-98) were sown in plastic pots containing sandy loam soil with 3 drought stress levels, i.e. wet conditions or flooded water (100% FC) as recommended control, 75% FC, 50% FC and 25% FC for chickpea. The moisture contents were maintained and regularly monitored through the addition of normal irrigation water. The design of experimental was completely randomized with 3 replicates per treatment. Penultimate leaves were harvested with knife after 20 days of foliar spray to observe the effect of exogenously applied ASA (100 mg/L) on growth, and key-biochemical attributes of chickpea plants (DG-89 and Bittle-98) under drought stress regimes. Drought stress regimes caused a substantial decline in shoot (37% and 35%) and root length (67% and 78%), shoot (80% and 76%) and root (62% and 68%) fresh masses, shoot (71% and 63%) and root (77% and 74%) dry masses, leaf area per plant (77% and 80%), chlorophyll a (7% and 45%), chlorophyll b (57% and 42%), total chlorophyll (30% and 39%), total carotenoids (76% and 54%), total anthocyanins (38%), reducing sugar (10% and 57%), total soluble proteins (77% and 44%), total flavonoids (61% and 59%) and total phenolics (58% and 31%) contents in both DG-89 and Bittle-98, respectively. A significant increase in MDA (25%), H2O2 contents (100% and 62%), proline (145% and 131%), and ascorbic acid (133% and 203%) contents was documented in stressed plants of both varieties, respectively. Additionally, drought stress significantly improved the activities of POD (154% and 76%), CAT (87% and 45%) and SOD (248% and 143%) in both varieties. Exogenous application of ASA reduced drought-mediated oxidative stress by reducing MDA (53% and 14%), and H2O2 (84% and 56%) contents, proline contents (50% and 17%) and enhanced the shoot (6% and 25%) and root (43% and 33%) dry masses, leaf area (9% and 10%), chlorophyll a (7% and 32%), b (82% and 81%), and carotenoids (53% and 33%) in both barley cultivars. When plants of chickpea was treated with ASA had greater total anthocyanins (26% and 35%), free amino acids (48% and 28%), ascorbic acid contents (135% and 179%), total soluble proteins (34% and 23%), total flavonoids (58% and 35%) and phenolic (50% and 69%)contents besides the POD (41% and 64%), CAT (23% and 56%) and SOD (73% and 72%) enzymes activities. Plants of DG-89 showed more tolerance to drought stress than that of Bittle-98 as a manifest from higher plant biomasses. Thus, our results showed that foliar-applied ASA is an effective strategy that can be used to improve the tolerance of chickpea plants to drought stress.
Amide Proton Transfer Imaging vs Diffusion Kurtosis Imaging for Predicting Histological Grade of Hepatocellular Carcinoma

Background To investigate the value of amide proton transfer (APT) imaging in predicting the histological grade of hepatocellular carcinoma (HCC), compared with diffusion kurtosis imaging (DKI). Methods A total of 88 patients with HCC were enrolled and divided into four groups (G1, G2, G3, and G4) based on histologic grades. Preoperative APT signal intensity (SI), mean diffusivity (MD), mean kurtosis (MK) of HCC were measured and compared. Those quantitative magnetic resonance imaging (qMRI) parameters were compared using an analysis of variance. The correlations between the qMRI parameters and the histological grades were determined using Spearman's rank analysis. In addition, the predictive performance for differentiating low- (G1 and G2) from high-grade (G3 and G4) HCC was evaluated using receiver operating characteristic (ROC) curve analysis. Results Significant differences were found in APT SIs, MD, and MK among the four groups (P<0.05). Moderate to good relationships were found between the histologic grade of HCC and APT SI and MK (r=0.679, P<0.001 and r=0.539, P<0.001, respectively). The area under the ROC curves (AUCs) of APT SI, MK, and MD for differentiating low- from high-grade HCC were 0.890 (95%CI: 0.805–0.947), 0.765 (95%CI: 0.662–0.849) and 0.717 (95%CI: 0.611–0.808), respectively. Comparison of ROC curves showed a significantly higher AUC of APT SI compared with those of the DKI-derived parameters (P <0.05). Conclusion The APT imaging may be more accurate than DKI for predicting the histological grade of HCC.