Miracle-dz/UniFAR-FTUs huggingface dataset:
Neural correlates of eating disorders: translational potential

: Eating disorders are complex and serious psychiatric illnesses whose etiology includes psychological, biological, and social factors. Treatment of eating disorders is challenging as there are few evidence-based treatments and limited understanding of the mechanisms that result in sustained recovery. In the last 20 years, we have begun to identify neural pathways that are altered in eating disorders. Consideration of how these pathways may contribute to an eating disorder can provide an understanding of expected responses to treatments. Eating disorder behaviors include restrictive eating, compulsive overeating, and purging behaviors after eating. Eating disorders are associated with changes in many neural systems. In this targeted review, we focus on three cognitive processes associated with neurocircuitry differences in subjects with eating disorders such as reward, decision-making, and social behavior. We briefly examine how each of these systems function in healthy people, using Neurosynth meta-analysis to identify key regions commonly implicated in these circuits. We review the evidence for disruptions of these regions and systems in eating disorders. Finally, we describe psychiatric and psychological treatments that are likely to function by impacting these regions.
notch inhibitor can attenuate apparent diffusion coefficient and improve neurological function through downregulating nOX2-rOs in severe traumatic brain injury

for Apparent diffusion coefficient (ADC) values can represent the brain edema after TBI. Methods: We established a rat model of acute craniocerebral injury, using functional MRI to evaluate the ADC and cerebral blood flow values. The present study was designed to determine the effect of Notch inhibitor DAPT upon oxidation stress for brain edema after TBI. Rats were randomly distributed into five groups, control group, severe TBI group, severe TBI + vehicle group, severe TBI + DAPT group, and severe TBI + DPI group. All rats were sacrificed at 24 hours after TBI. Results: Our data indicated that Notch signaling inhibitor DAPT significantly reduced the ADC values and improved the neurological function after TBI. In addition, DAPT decreased NOX2 levels and the ROS levels. Furthermore, DPI can decrease NOX2 levels and ROS levels. Conclusion: This study indicated that DAPT Notch signal inhibitors can inhibit NOX2-ROS generation, reduce the ADC values, relieve cerebral edema, and improve nerve function.
Intratumoral expression levels of PD-L 1 , GZMA , and HLA-A along with oligoclonal T cell expansion associate with response to nivolumab in metastatic melanoma 著者

volume 5 number 9 page range e1204507 year 2016-06 権利 (C) 2016 The Author(s). Published with license by Taylor & Francis Group, LLC(C) Hiroyuki Inoue, Jae-Hyun Park, Kazuma Kiyotani, Makda Zewde, Azusa Miyashita, Masatoshi Jinnin, Yukiko Kiniwa, Ryuhei Okuyama, Ryota Tanaka, Yasuhiro Fujisawa, Hiroshi Kato, Akimichi Morita, Jun Asai, Norito Katoh, Kenji Yokota, Masashi Akiyama, Hironobu Ihn, Satoshi Fukushima, and Yusuke Nakamura. This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0 /), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted. URL http://hdl.handle. net/2241/00144418
Optimizing the Definitions of Stroke, TIA and Infarction for Research and Application in Clinical Practice

Publisher Rights Statement: © 2017 Abbott, Silvestrini, Topakian, Golledge, Brunser, de Borst, Harbaugh, Doubal, Rundek, Thapar, Davies, Kam and Wardlaw. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Overexpression of cD300a inhibits progression of nsclc through downregulating Wnt/ β -catenin pathway

Background: CD300A, a type I transmembrane glycoprotein receptor, plays an important role in immune response. Recent studies have reported that CD300A is involved in the development of hematological malignancies. Purpose: The objective of this study was to investigate the role of CD300A in the progression of non-small-cell lung cancer (NSCLC) and explore the associated mechanism. Materials and methods: Gene Expression Profiling Interactive Analysis (GEPIA) was used to analyze the expression of CD300A in NSCLC and its prognostic value. NSCLC cell lines A549 and H1650 were transfected with siRNA-CD300A or pcDNA3.1-CD300A vector to down- or up-regulate the expression of CD300A. Cell Counting Kit 8, colony formation and Transwell assays were used to assess the effects of CD300A on cell proliferation and migration capacities. Flow cytometry was performed to examine rate of apoptosis, and the protein levels of associated proteins was detected using Western blot assay. Results: From GEPIA analysis, we observed that expression of CD300A mRNA was downregulated in NSCLC and positively correlated with the overall survival of NSCLC patients. Overexpression of CD300A significantly suppressed cell growth and migration capacities of A549 and H1650 cells and induced cell apoptosis via regulating apoptosis-related proteins. Moreover, decreasing level of CD300A promoted cell growth and migration and blocked apoptosis of NSCLC cells. Furthermore, upregulation of CD300A led to significant decrease in expression level of Wnt3 and β -catenin, the pivotal components in Wnt/ β -catenin signaling pathway, and an increase in expression of E-cad, a key protein in tumor metastasis, in A549 and H1650 cells; while depletion of CD300A up-regulated the Wnt/ β -catenin signaling pathway. In conclusion, the present study highlighted an anti-oncogenic role of CD300A in the progression of NSCLC via inhibiting Wnt/ β -catenin pathway, suggesting that CD300A might be a potential target for the treatment of NSCLC Conclusion: CD300A plays an anti-oncogenic role in the progression of NSCLC through inhibiting the Wnt/ β -catenin pathway, suggesting that CD300A might be a potential target for the treatment of NSCLC.
Acute exacerbation in interstitial lung disease

BACKGROUND: Information regarding acute exacerbation (AE) in patients with interstitial lung disease (ILD) is limited. OBJECTIVES: The objective of the study was to elucidate the clinical features and outcome of AE among ILD patients. METHODS: We retrospectively analyzed the data of 667 consecutive ILD (nonidiopathic pulmonary fibrosis [IPF] ILD, n = 463; IPF, n = 204) patients. ILD patients meeting the 2016 definition of AE-IPF were identified. Information analyzed included pulmonary function tests, 6-min walk tests, and right heart catheterization data, among others. Cox regression models were used to identify independent predictors of survival. RESULTS: AE was identified in non-IPF ILD (n = 113) and IPF (n = 74). Compared with AE-IPF patients, non-IPF ILD patients with AE were of younger age, predominantly women, and primarily nonsmokers (all, P < 0.0001). The estimated survival probabilities at 1, 3, and 5 years were 88%, 75%, and 70%, respectively, in the ILD without AE group; 80%, 57%, and 50%, respectively, in the non-IPF ILD with AE group; and 53%, 38%, and 28%, respectively, in the AE-IPF group (P < 0.0001 by log-rank analysis). Age, body mass index, IPF diagnosis, AE, diffusion capacity of the lung for carbon monoxide <35% predicted, 6-min walk distance <300 meters, and cardiac index were independent predictors of survival in the ILD cohort. CONCLUSIONS: Non-IPF ILD patients with AE have distinct clinical features compared to AE-IPF patients. Importantly, AE is one of many independent risk factors associated with worsened outcomes regardless of the underlying ILD type.
a comparative analysis of errors in inhaler technique among COPD versus asthma patients

Purpose: This study was designed to evaluate errors in inhaler technique in COPD vs asthma patients and to investigate the association of poor inhaler technique with patient demographics and clinical variables. Patients and methods: A total of 509 adult patients with COPD (n = 328) or asthma (n = 181) who were currently using an inhaler device were included in this study. Data on patient demographics, duration of disease, type and duration of inhaler therapy, and assessment of inhaler technique were recorded. Results: Metered dose inhaler (MDI) was the most common type of inhaler used by a similarly high percentage of patients in both COPD (83.2%) and asthma (77.3%) groups. Failure to exhale before inhaling through device (75.8% and 68.5% for MDIs; 73.2% and 71.8% for Aerolizer ® / Handihaler ® ; 53.1% and 66.7% for Turbuhaler ® ) was the most common error in inhaler technique, in both COPD and asthma groups. Device-specific errors in inhaler techniques were more common in asthma patients as compared with COPD patients, particularly for MDIs ( P -values ranged from 0.046 to 0.0005), as associated with female gender (failure to press the buttons on both sides of Aerolizer ® /Handihaler ® , P = 0.006), shorter duration of disease (failure to hold MDI or head in a vertical position, P , 0.001, and to keep Turbuhaler ® upright, P = 0.005), and shorter duration of inhaler usage (failure to hold head in a vertical position during MDI usage, P = 0.006, and to keep Turbuhaler ® upright, P = 0.012). Conclusion: In conclusion, our findings revealed that errors in inhaler technique in terms of inhalation maneuvers and device handling were similarly common in COPD and asthma patients. Errors in certain device handling maneuvers, particularly with MDIs, were more common among asthma patients than among COPD patients and associated with female gender and shorter durations of disease and inhaler therapy.
Prevalence, virulence genes, and antimicrobial profiles of Escherichia coli O157:H7 isolated from healthy cattle in Tunisia.

INTRODUCTION Shiga toxin-producing Escherichia coli (STEC) O157:H7 is associated with intestinal infection in humans and is considered an important cause of food-borne diseases. The aim of the study was to assess the incidence of E. coli O157:H7 in fecal samples of healthy cattle collected in slaughterhouses (n = 160) and from five farms (n = 100). METHODOLOGY E. coli isolates were detected on MacConkey agar. A total of 236 E. coli isolates were recovered from fecal samples of healthy cattle. We used sorbitol MacConkey medium to detect non-sorbitol fermenting colonies. These bacteria were examined for the presence of O157:H7 antigen by latex agglutination. The isolation of E. coli O157:H7 has been confirmed with PCR amplification of rfbEO157 and fliCH7 specific genes for serogroup O157 and with multiplex PCR of stx1, stx2, eaeA, and ehxA. All isolates were examined for their susceptibility to 21 antibiotics by the disc diffusion method. RESULTS Of the 236 E. coli isolates, 4.2% (10/236) were positive for STEC O157:H7. Shiga toxin gene (stx2) and ehxA were present in 70% of isolates, stx1 and eae were confirmed in 60% of the isolates. Other virulence factors screened (fimH, sfa/focDE, cdt3, traT, iutA, and hlyA) were present among the 10 isolates. All E. coli O157:H7 isolates were sensitive to amoxicillin/clavulanic acid, cefotaxime, cefepime, aztreonam, colistin, and sulfamethoxazole/trimethoprim. All isolates belong to the phylo-group E. CONCLUSIONS This is the first study of the incidence of E. coli O157:H7 in cattle in Tunisia. Our finding proves the existence of STEC O157:H7 in healthy animals producing food for human consumption which could be a source of food-borne disease.
Patient safety culture from the perspective of all the workers of a general hospital.

OBJECTIVE To assess the patient safety culture among the workers of a hospital institution in southern Brazil. METHOD This is a cross-sectional study, which was performed with 630 hospital workers, at Santa Rosa, Rio Grande do Sul, Brazil, through the Safety Attitudes Questionnaire tool, in the month of April 2017. RESULTS We found positive scores in all the safety culture domains, except for the perceived stress domain. CONCLUSION Job satisfaction and teamwork spirit showed better scores for nursing and health professionals, when compared to the support team. Schooling, gender, operation time and the choice of workplace positively influenced the safe atmosphere.
Adapting Buildings and Cities for Climate Change: A 21st Century Survival Guide

Preface Acknowledgements 1 Climate change: the battles begins 2 The evolution of buildings 3 Risk, scenarios and climate change 4 How hot will it get? 5 Thermal comfort 6 How wet will it get? 7 Wind storms 8 Sea level rises 9 Vulnerability, exposure and migration 10 Air-conditioning the ultimate solution? 11 Tall buildings 12 The fossil fuel crisis 13 Fuel security: when will the lights go out? 14 The players 15 Resilient buildings Index.
alcoholic liver disease and risk of cholangiocarcinoma: a systematic review and meta-analysis

contributed to this work Background: With the purpose of elevating the risk of cholangiocarcinoma (CCA), alcoholic liver disease (ALD) was shown. Nonetheless, the findings were controversial. Herein, a meta-analysis and a systematic review were conducted to study the relation as mentioned above. Methods: This study searched PubMed, EMBASE, and SI Web of Science carefully for the related studies published prior to March 2018, followed by the random-effects model to cal-culate the values of pooled risk ratio with 95% CIs. In addition, the analyses of sensitivity and subgroup were carried out to further confirm the stability of the outcomes. Results: Seven articles, consisting of 413,483 healthy controls and 8,962 CCA patients, were included in this meta-analysis. When compared with normal controls, patients with ALD had an enhanced 3.92-fold CCA risk, with studies being heterogeneous (95% CI = 1.96–5.07; OR = 3.92; I 2 = 70.2%). However, subgroup analysis showed that ALD had the enhanced risk of intrahepatic cholangiocarcinoma (ICC), instead of extrahepatic cholangiocarcinoma (ECC) (ICC: 95% CI = 3.06–5.92, OR = 4.49; ECC: 95% CI = 0.90–3.35, OR = 2.12). Additionally, when the analysis was stratified by the geographic area, positive association was observed only in western countries rather than eastern countries (western nations: 95% CI = 3.34–6.96, OR = 5.15; eastern nations: 95% CI = 0.38–3.91, OR = 2.14). And no essential bias was published. Conclusion: ALD was greatly associated with the enhanced risk of CCA by 3.92-fold, especially in the ICC.
Insect recovery after the Permian/Triassic crisis

Three main stages of insect fauna development in the Triassic are outlined: Early Triassic survival (‘post-Paleozoic’); Anisian–Carnian acme (‘Triassic sensu genuino’); Carnian–norian rise of the Late Mesozoic elements (‘pre-Jurassic’). Rhaetian insect fauna is virtually indistinguishable from the Early Jurassic one (‘quasi-Jurassic’). Changes in aquatic insect assemblages are specially considered.
Linagliptin and its effects on hyperglycaemia and albuminuria in patients with type 2 diabetes and renal dysfunction

Groop , P-H , Cooper , M E , Perkovic , V , Hocher , B , Kanasaki , K , Haneda , M , Schernthaner , G , Sharma , K , Stanton , R C , Toto , R , Cescutti , J , Gordat , M , Meinicke , T , Koitka-Weber , A , Thiemann , S & von Eynatten , M 2017 , ' Linagliptin and its effects on hyperglycaemia and albuminuria in patients with type 2 diabetes and renal dysfunction : the randomized MARLINA-T2D trial ' Diabetes, obesity and metabolism , vol. 19 , no. 11 , pp. 1610-1619 . https://doi.org/10.1111/dom.13041
Hepatitis B virus infection: Epidemiology and seroprevalence rate amongst Negrito tribe in Malaysia.

INTRODUCTION Prevalence of Hepatitis B virus (HBV) infection among the non-indigenous people in Malaysia has been well established and range between 3% and 5%. However, data from the indigenous (Orang Asli) people is still lacking. The Negrito population is the most remotely located Orang Asli tribe with limited access to health care facilities. This study was undertaken to determine the epidemiology and seroprevalence of HBV infection among the Negrito. METHODS Surveys were conducted in five Negrito settlements in Kelantan and Perak states in Malaysia. A total of 150 participants were recruited. Clinical history was taken and physical examination was performed. Five millilitres of whole blood were collected and tested for hepatitis B surface antigen (HBsAg) using electrochemiluminescence immunoassay. RESULTS Participants were mainly from the Bateq (49.3%) and Mendriq (29.4%) sub-tribes. Overall, 13 subjects (8.7 %); nine males and four females were HBsAg positive. Nine of the HBsAg positive subjects were ≥35 years old. All of them had history of home deliver without evidence of antenatal record. Six (46%) of the HBsAg positive subjects had tattoo and body piercing in the past. CONCLUSION The prevalence of HBV infection rate amongst the Negrito tribe is almost three-fold compared to the national rates. The reason for this finding remains unclear. Tattooing, body piercing and vertical transmission could be the main possible routes of transmission of HBV among the Negrito population in Malaysia.
evaluation of anxiety condition among type 1 and type 2 diabetic patients

Purpose: This study was conducted for the purpose of determining the relationship between type 1 and type 2 diabetic patients and anxiety. Method: This study was conducted between August and September 2015 at Bingol State Hospital. The study included 131 patients with diabetes mellitus (DM) followed up at the Internal Diseases Polyclinic of Bingol State Hospital. The questionnaire used in the study consisted of two parts. The first part of the questionnaire comprised a set of questions querying the sociodemographic characteristics and the second part comprised the Beck Anxiety Inventory. Results: The incidence of Type 1 DM was found to be higher among female compared to male patients, whereas type 2 DM was found to be higher among male compared to female patients, and this difference was statistically significant. According to the results of Beck Anxiety Scale (BAS) applied to the patients to examine their psychological states, 94.2% of male and 96.8% of female patients were found to be in the severe anxiety group. Among both male and female patients, BAS scores of the type 2 DM patients were higher than those of type 1 DM patients. When the distribution of BAS scores among the patients was examined, it was found that males received 44.7 ± 13.2 points and females received 47.0 ± 13.0 as mean value, but no statistically significant difference was found between BAS scores by sex. Unlike female patients, the difference between duration of disease and BAS score was found to be statistically significant in male patients. Conclusion: In planning the treatment of patients with diabetes, evaluating them mentally will help to provide optimal treatment and care services.
Intrapulmonary Pharmacokinetics of Relebactam , a Novel β-lactamase Inhibitor , 1 Dosed in Combination with Imipenem / Cilastatin in Healthy Subjects 2 3 Running

Intrapulmonary Pharmacokinetics of Relebactam, a Novel β-lactamase Inhibitor, 1 Dosed in Combination with Imipenem/Cilastatin in Healthy Subjects 2 3 Running Title: Relebactam with Imipenem/Cilastatin, Intrapulmonary PK 4 5 Matthew L. Rizk, Elizabeth G. Rhee, Patricia A. Jumes, Mark H. Gotfried, Tian Zhao, Eric 6 Mangin, Sheng Bi, Cynthia M. Chavez-Eng, Zufei Zhang and Joan R. Butterton 7 1 Merck & Co., Inc., Kenilworth, NJ, USA 8 2 Pulmonary Associates, Phoenix, AZ, USA 9 ⃰ Current affiliation: GlaxoSmithKline, King of Prussia, PA, USA 10 11 # Corresponding author: Matthew L. Rizk, PhD, Merck & Co., Inc., Kenilworth, NJ, USA 12 (267) 305-8035, matthew.rizk@merck.com 13 Elizabeth G. Rhee: elizabeth.rhee@merck.com 14 Patricia A. Jumes: patricia.jumes@merck.com 15 Mark H. Gotfried: mgotfried@aol.com 16 Tian Zhao: tian.zhao@merck.com 17 Eric Mangin: eric.mangin@merck.com 18 Sheng Bi: sheng_bimk@yahoo.com 19 Cynthia M. Chavez-Eng: cynthia.chavezeng@merck.com 20 Zufei Zhang: zufei.zhang@merck.com 21 Joan R. Butterton: joan.butterton@merck.com 22 23
GENDER ISSUES IN BEEKEEPING: THE UGANDA CASE

Uganda is an Agricultural Country . There is a gender in balance in this sector . Workforce in the Agriculture Sector is mainly Women . There is an increasingly need for women to participate actively in the Beekeeping sector. This will enhance increase in crops yield since bees play a major role in pollination crops and abundant harvest from the hives as the flowering plants/crops will be a source of nectar & pollen for the bees
Bridging the Age Gap in breast cancer: Impact of chemotherapy on quality of life in older women with early breast cancer

Introduction: Older patients with early breast cancer (EBC) derive modest survival beneﬁt from chemotherapy but have increased toxicity risk. Data on the impact of chemotherapy for EBC on quality of life in older patients are limited, but this is a key determinant of treatment acceptance. We aimed to investigate its effect on quality of life in older patients enrolled in the Bridging the Age Gap study. Materials and methods: A prospective, multicentre, observational study of EBC patients (cid:1) 70 years old was conducted in 2013 e 2018 at 56 UK hospitals. Demographics, patient, tumour characteristics, treatments and adverse events were recorded. Quality of life was assessed using the European Organisation for Research and Treatment of Cancer Quality-of-Life Questionnaires (EORTC-QLQ) C30, BR23 and ELD 15 plus the Euroqol-5D (eq-5d) over 24 months and analysed at each time point using baseline adjusted linear regression analysis and propensity score-matching. Results: Three thousand and four hundred sixteen patients were enrolled in the study; 1520 patients undergoing surgery and who had high-risk EBC were included in this analysis. 376/ 1520 (24.7%) received chemotherapy. At 6 months, chemotherapy had a signiﬁcant negative impact in several EORTC-QLQ-C30 domains, including global health score, physical, role, social functioning, cognition, fatigue, nausea/vomiting, dyspnoea, appetite loss, diarrhoea and constipation. Similar trends were documented on other scales (EORTC-QLQ-BR23, EORTC-QLQ-ELD15 and EQ-5D-5L). Its impact was no longer signiﬁcant at 18 e 24 months in unmatched and matched cohorts. Conclusions: The negative impact of chemotherapy on quality-of-life is clinically and statistically signiﬁcant at 6 months but resolves by 18 months, which is crucial to inform decision-making for older patients contemplating chemotherapy.