Miracle-dz/UniFAR-FTUs huggingface dataset:
Breast Cancer Chemotherapy In Pointe Noire

Objective: The objective of our study was to determine chemotherapy and these frequent side effects of breast cancer in Pointe-Noire. Patients and Methods: This was a retrospective descriptive study that took place in the cancerology and internal medicine department during the period from January 1, 2019 to December 31, 2021. Were included in our study: patients with and histological diagnosis, and having received at least one course of chemotherapy and having presented hematological toxicity: anemia and/or neutropenia. Patients having status performances less than 2. The variables studied were: Age, level of study, stage of extension, type of chemotherapy, type of toxicity. L4ANA The khi2 was used and results were statistically significant for a value of P<5%. Results: The average age of the patients was 50.35 ± 13.6 years. The extremes were 27 years and 79 years old. The most represented age group was the age group from 37 to 46 years with 18 cases or 33.33%. The most represented level study in our study was the primary level 70%, followed by secondary level 26% and the upper or superior level 11%. Metastatic stage of location was represented in 16.6% of cases, the local stage was represented in 16.7% of cases. The most commonly chemotherapy used was FAC protocol in 50% of cases, followed by FAC+DOCETAXEL in 47% of cases, AC protocol was used in 3% of cases The majority of patients had received more than 3 courses of chemotherapy in 83% of cases case. Frequent toxicities were fatigue 100%, alopecia 100%, nausea 100%, hematological 95%, vomiting 20%. The most used chemotherapy was FAC type chemotherapy in 19 cases, 4 cases, 2 cases respectively at the locoregional, metastatic and local stages. Conclusion: Chemotherapy for breast cancers in our context with limited resources is of the anrhracyclines (AC, FAC) and taxanes (docetaxel) type. These chemotherapies are responsible for haematological toxicities, fatigue, nausea, vomiting and alopecia.
Automated writing evaluation tools for Indonesian undergraduate English as a foreign language students’ writing

Nowadays, many computer programs are used in the teaching of writing in the context of English as a foreign language (EFL). One of the functions of the computer programs is to provide feedback to EFL students’ writing so that the quality of their writing can be improved. This study aimed to investigate whether the use of free automated writing evaluation (AWE) tools affect undergraduate EFL students’ writing skills. In this experimental study, 35 Indonesian undergraduate students of English education department were asked to use two AWE tools, Grammarly and Grammark, in the writing course over four months. Data for this study were collected by using tests and questionnaire. Pre-test, middle test, and post-test were administered to examine the students’ writing skill improvement. The findings indicate that the sequenced use of two AWE tools, Grammarly followed by Grammark, had a beneficial effect on students’ writing skill improvement. This study confirms the benefits of free AWE tools in enhancing EFL students’ writing skills.
Level of motion sickness based on heart rate variability when reading inside a fully automated vehicle

This study investigates the level of experienced motion sickness when performing reading while being driven in fully automated driving under three different conditions. One condition was without any intervention while the other two conditions were with the visual (VPIS) and haptic (HPIS) peripheral information system. Both systems provided the upcoming navigational information in the lateral direction three seconds before the turning/cornering was done. It was hypothesized that with the peripheral information systems, the experienced motion sickness would be reduced compared to the condition where a peripheral information system was not present. Eighteen participants with severe motion sickness susceptibility were carefully chosen to undergo the conditions using an instrumented vehicle with the Wizard-of-Oz approach. The participants were required to read from a tablet during the whole 15-minutes of automated driving. Results from the heart rate variability (beats per minute, root means square of successive differences, and high-frequency component) indicated no statistically significant changes (p < 0.05) in motion sickness found with the presence of HPIS and VPIS when performing reading when being driven in automated mode. However, results from this study were mixed and inconclusive, but overall findings indicated mild motion sickness was found in both VPIS and HPIS conditions.
Adherence Barriers to Treatment of Patients with Cardiovascular Diseases: A Qualitative Study

Background: Adherence to treatment is highly important in the management of Cardiovascular Diseases (CVD). Barriers to effective and long-term adherence to treatment by the patient make achieving care and treatment goals challenging. The aim of this study was to identify the adherence barriers to the treatment plan in patients with CVD. Materials and Methods: A qualitative content analysis study was conducted to explore the experience of patients, family caregivers, and healthcare professionals (n = 35) using qualitative content analysis. The study was carried out between 2019 and 2020 in Isfahan, Iran. Purposive sampling was performed. Data collection was conducted through in-depth interviews and semi-structured until data saturation. Graneheim and Landman content analysis was performed simultaneously with data collection. Results: After data analysis, 3 themes and 6 categories were identified and named. Themes (and categories) include “Patients unreadiness to change” (misunderstanding of conditions and consequences and deterrence cultural practices and beliefs); “gap in healthcare services” (lack of adequate support for patients and discordance between healthcare professionals); and “limited access to healthcare services” (limited physical access and financial burden). Conclusions: The findings of the present study can provide a framework for healthcare professionals to employ preventive strategies, reduce disease complications, decrease unhealthy behaviours, and increase prolonged adherence to treatment recommendations in patients with CVD.
Women's and Care Providers’ Perspectives of Quality Preconception Care: A Qualitative Descriptive Study

Background: A growing body of evidence is showing that Preconception Care (PCC) can increase the health and well-being of women and couples and improve subsequent pregnancy and child health outcomes. The present study aimed to determine the quality of preconception care from women's and care providers' perspectives. Materials and Methods: This qualitative study was conducted in 2020 using conventional content analysis approach. Face to face Semi-structured interviews were conducted with 13 reproductive age women and 12 midwives recruited from urban health centers across Shahroud, Iran. Data were analyzed using qualitative content analysis. Results: Three major themes based on Donabedian's model emerged during data analysis: structure, process and outcome of care. Midwives and women's experiences of quality of preconception care included problems in organizing care, poor education performance of personnel and low-sensitivity about importance of preconception care in women. Conclusions: The findings suggest key considerations for the organizing and delivery of preconception care. Most especially, it seems necessary to adopt appropriate strategies to improve public awareness about the importance of pre-pregnancy care.
Breast Implant–Related Adverse Events During Mammography

Background Adverse events arising in patients with breast implants during mammography reported by the Food and Drug Administration include implant rupture, pain, and impaired visualization. However, data supporting these claims were collected in 2004, and since, newer implant generations have been developed with overall rate of implantation increasing by 48%. Objectives This article aims to determine the current incidence of implant-related adverse events arising during mammography. Methods We analyzed reports regarding silicone and saline breast implants published in the Food and Drug Administration Manufacturer and User Facility Device Experience database between 2008 and November 2018. Search terms included “mammogram,” “mammography,” “radiograph,” “breast cancer screening,” “breast cancer test,” and “x-ray. ” Results Of the 20 539 implant-related adverse events available in the Manufacturer and User Facility Device Experience database, 427 were retrieved using our search strategy and 41 were related to mammography. Thirty-five of identified cases (85.4%) reported implant rupture, of which 19 (54.3%) were confirmed by a healthcare professional, 9 (25.7%) were clinically confirmed by saline implant deflation, and 7 (20.0%) were unverified reports by patients. Sixteen ruptures (45.7%) occurred with silicone implants, whereas 19 ruptures (54.3%) occurred with saline. Other adverse events included pain (29.3%), change in implant appearance (14.6%), and swelling (7.3%). Conclusions Although implant rupture, pain, change in implant appearance, and swelling may occur, minimal implant-related adverse events arise during mammography. Given the extremely low reported risk of implant rupture, this should neither prevent patients from adhering to breast cancer screening programs nor deter patients from seeking breast implants. Patients should be aware of these reported risks and discuss screening options with their breast cancer screening team.
CodeToon: Story Ideation, Auto Comic Generation, and Structure Mapping for Code-Driven Storytelling

Recent work demonstrated how we can design and use coding strips, a form of comic strips with corresponding code, to enhance teaching and learning in programming. However, creating coding strips is a creative, time-consuming process. Creators have to generate stories from code (code↦story) and design comics from stories (story↦comic). We contribute CodeToon, a comic authoring tool that facilitates this code-driven storytelling process with two mechanisms: (1) story ideation from code using metaphor and (2) automatic comic generation from the story. We conducted a two-part user study that evaluates the tool and the comics generated by participants to test whether CodeToon facilitates the authoring process and helps generate quality comics. Our results show that CodeToon helps users create accurate, informative, and useful coding strips in a significantly shorter time. Overall, this work contributes methods and design guidelines for code-driven storytelling and opens up opportunities for using art to support computer science education.
Development of Bio-control Technology for Subterranean Termites Coptotermes curvignathus Holmgren Using Electromagnetic Waves

This paper proposes a non-destructive technology to control subterranean termites Coptotermes curvignathus Holmgren infestations. In the experiment, the apparatus for termites control used electromagnetic waves at two frequencies: 300 Hz and 300 kHz. Termites were exposure to electromagnetic waves on direct methods with variation of exposure time 15, 30, 45 and 60 min respectively. The use of electromagnetic waves for termites control are very beneficial, they are odorless, noiseless, friendly to environment, and easy to apply. The result showed that electromagnetic waves had an effect to termites. The value of termites mortality was range between 25.45~82.27% and the average value of termites filter paper consumption was between 8.89~39.44%. Meanwhile on control treatment, termites mortality and termites filter paper consumption were respectively 14.05% and 79.88% in average. The highest frequency of electromagnetic waves and the longest irradiation time caused the highest average value of termites mortality. The magnitude field from apparatus was range between 0.069~0.1815 μT, which is safe to utilize around the human body. The best result was achieved on frequency 300 kHz and irradiation time 60 min. These results represent important information about the potential use of electromagnetic waves technology for termites control as an environmentally benign alternative in spite of the insecticides uses.
Divergent nitrogen and phosphorus allocation strategies in terrestrial plant leaves and fine roots: A global meta‐analysis

The quantification of the allocation of nitrogen (N) and phosphorus (P) among plant organs is essential to improve our understanding of plant growth, life‐history strategies and ecosystem nutrient and energy cycles. However, allocation strategies of N and P between terrestrial plant leaves and fine roots are unclear. Here, we compiled a global dataset comprising 807 terrestrial plant species to analyse the stoichiometric scaling of N and P between leaves and fine roots across species, families, plant groups, biomes and locations. We found that N and P, and N:P ratios manifest different scaling exponents (α‐values) between leaves and fine roots. Specifically, overall αN and αP were >1 and <1, respectively, and αN:P = 1, indicating a higher proportional increase of N to fine roots and P to leaves. However, there were differences in αN, αP and αN:P among major species, families, plant groups, biomes and locations. In addition, αN and αN:P increased with latitude; there was no clear trend for αP. Mean annual temperature accounted for the greatest proportion of variation in αN, whereas soil total P accounted for the greatest proportion of variation in αP and αN:P. Synthesis. Our results demonstrate a divergent N and P allocation strategy between leaves and fine roots in terrestrial plants. This study improves our understanding of the effects of the environment (including changes in global climate and life‐history strategies) on nutrient allocation patterns between these two important plant organs.
Role of Community Pharmacist in Public Health Services, Riyadh, Saudi Arabia

Background and Aims: Currently, the scope of practice has allowed pharmacists to engage in the clinical aspects of direct patient care and public health services to the patient. This study's main objective is to investigate community pharmacists' involvement in public health services and the barriers in the health system that hinder the integration of community pharmacy professionals into the public health task in the local context of Saudi Arabia. Methods: A cross-sectional survey was conducted in community pharmacies in a different region of Riyadh, Saudi Arabia (June and July 2019). A sample was calculated to include 431 pharmacists working in different community pharmacies proportionally randomly selected from the five areas in Riyadh city. A multistage, stratified, random sample method was used. Data analysis was performed using SPSS software. A P value < 0.05 considered as statistically significant. Results: The 431 participants showed the dominance of male pharmacists (97.2%), non-Saudi (84.9%), and Bachelor’s pharmacy degrees (81.2%). Most of the participants were involved in smoking cessation (83.1%) as public health services, weight management (62.4%), but less involvement in activities related to physical activities or dietary intake (33.0%, 31.8%, respectively). More likely the involvement of the Saudi pharmacist in lifestyle activities in comparison to non-Saudi (AOR:1.932; 95% CI: 1.125 - 3.320). Moreover, the perceived barrier in the involvement level was more associated with years of experience. Conclusion: This study showed that community pharmacists should play an important role in health promotion and prevention; they recognize a wide gap between ideal and actual levels of participation. The researcher presents the main barriers to the role of the pharmacist to improve the level of the individual and society because many obstacles limit the role of the pharmacist in public health.
Insight Into Io Enabled by Characterization of Its Neutral Oxygen Torus

The Jovian system is very intriguing with extremely different particle sources. As the dominant source of particles to Jupiter's magnetosphere, Io is of particular importance. The JAXA Hisaki (SPRINT‐A) mission is providing insightful observations with regard to Io. In particular, its UV neutral oxygen line of sight observations provide the best glimpse so far of Jovian neutral particle populations. This is exciting in that for the first time, the neutral tori can be directly observed on time scales that constrain satellite sources. This data also sheds unprecedented insight into neutral torus distributions, which could subsequently provide essential information about the sources and mechanisms from Io. However, 3‐D modeling is also required to interpret the complex and dynamic observational geometries. Here, we present the first 3‐D distribution of the Io‐generated neutral oxygen torus using JAXA Hisaki neutral oxygen observations as modeling constraints to provide characterization of the Io magnetospheric source and the resulting neutral tori. Major findings of our research include: (a) the effective total original SO2 source rate from Io during a low activity period is ∼800 kg/s; (b) Io has two separate exospheric sources: O at ∼200 kg/s and SO2 at ∼400 kg/s; (c) particles escape from Io preferentially on the Jupiter upstream facing hemisphere; (d) the oxygen neutral torus populates the entire orbit and significantly dominates over the SO2, SO, and S neutral toroidal clouds; and (e) large ionization and dissociation rates limit the significant expansion of Io‐genic neutral particles in Jupiter's magnetosphere beyond ∼2 Rj from Io's orbit.
Investigating the Performance of a Fully Laminated Flux-Focusing Magnetic Gearbox

This paper presents the design investigation and experimental testing of a flux-focusing magnetic gearbox with a fully laminated rotor structure. The unique feature of this flux-focusing magnetic gearbox design is that the three rotors are each made of a single lamination stack, and the central modulation structure is retained in place without the use of a resin filler such as epoxy. Ferromagnetic bridges are used to connect individual pole pieces together. It is shown that the use of the ferromagnetic bridges reduces the calculated torque density from 156Nm/L to 139Nm/L (a reduction of 11%). The experimentally measured torque density is, however, only 97Nm/L. The reason for this discrepancy is associated with the demagnetization of the magnets.
Prognostic factors and molecular subtypes in young women with breast cancer

Introduction: Because of its high incidence, breast cancer is the subject of numerous studies today. Despite being an uncommon disease in young women, when it affects this population, it tends to be more aggressive and has high mortality rates. Objective: The objective of this study was to evaluate the prognostic factors present in the immunohistochemical profile of young women with breast cancer, comparing the age groups of very young women (<35 years old — Group I) and young women (between 35 and 40 years old — Group II), to see if the data obtained match what is reported in the literature. Methods: A cross-sectional study was carried out, analyzing the immunohistochemical tests of 90 female patients with invasive breast carcinoma. The groups were classified on the basis of molecular subtype: luminal A, luminal B, hybrid luminal, human epidermal growth factor receptor 2 positive and triple-negative. Results: The histological type with the highest incidence was invasive breast carcinoma of no special type. The most frequent molecular subtypes were luminal B and triple-negative. With regard to estrogen and progesterone receptors, there was a slight predominance of positive receptors. Ki-67 levels showed that in the triple-negative and human epidermal growth factor receptor 2 positive subtypes, there was a predominance of high cell proliferation index. Conclusion: In the population of young women in this cohort of patients, there was agreement with literature data regarding the predominance of the invasive carcinoma of no special type histological type and the luminal B and triple-negative molecular subtypes, and the presence of high cell proliferation rates, attesting to the higher prevalence of more aggressive tumors in the younger population. There was also no statistically significant difference in all aspects analyzed when comparing Groups I and II. However, a higher frequency of negative hormone receptors or overexpressed human epidermal growth factor receptor 2 molecular subtypes was not detected, characteristics that are common to young women with breast cancer, which has been pointed out in several studies worldwide.
Changes in DNA double-strand break repair during aging correlate with an increase in genomic mutations

A double -strand break (DSB) is one of the most deleterious forms of DNA damage. In eukaryotic cells, two main repair pathways have evolved to repair DSBs, homologous recombination (HR) and non-homologous end-joining (NHEJ). HR is the predominant pathway of repair in the unicellular eukaryotic organism, S. cerevisiae. However, during replicative aging the relative use of HR and NHEJ shifts in favor of end-joining repair. By monitoring repair events in the HO-DSB system, we find that early in replicative aging there is a decrease in the association of long-range resection factors, Dna2-Sgs1 and Exo1 at the break site and a decrease in DNA resection. Subsequently, as aging progressed, the recovery of Ku70 at DSBs decreased and the break site associated with the nuclear pore complex at the nuclear periphery, which is the location where DSB repair occurs through alternative pathways that are more mutagenic. End-bridging remained intact as HR and NHEJ declined, but eventually it too became disrupted in cells at advanced replicative age. In all, our work provides insight into the molecular changes in DSB repair pathway during replicative aging. HR first declined, resulting in a transient increase in the NHEJ. However, with increased cellular divisions, Ku70 recovery at DSBs and NHEJ subsequently declined. In wild type cells of advanced replicative age, there was a high frequency of repair products with genomic deletions and microhomologies at the break junction, events not observed in young cells which repaired primarily by HR. Highlights Decreased DNA resection at DSBs is an early event of replicative aging End-joining repair increases as resection decreases at DSBs in older cells In older cells the products of DSB repair contain deletions and microhomologies DSBs associate with the NPC at the nuclear periphery more in older cells Old Cell Enrichment method suitable for molecular biology approaches in budding yeast
The Features of Emerging Adulthood and Individuation: Relations and Differences by College-Going Status, Age, and Living Situation

This study investigated how emerging adults’ processes of individuation from their parents relate to their perceptions of Arnett’s defining features of emerging adulthood. It specifically examined differences in perceptions of emerging adulthood and individuation as functions of college-going versus non-college-going status, age across the full emerging adult range (18–29), and living situation (independently or with parents), as well as explored these factors’ potential moderating roles. Structural equation modeling analyses showed many of the positive dimensions of individuation (such as self-reliance and support-seeking from parents) related to the more adaptive features of emerging adulthood (such as identity exploration and sense of possibilities), though not all relations suggested developmental desirability. Perceptions of emerging adulthood differed by both college-going status and age; college-going status moderated many of the individuation-emerging adulthood relationships. The findings suggest perceptions of emerging adulthood cannot be fully understood without considering the roles of college-going, age, and individuation.