Miracle-dz/UniFAR-FTUs huggingface dataset:
IMMUNO-HISTOCHEMICAL CHANGES TRIGGERED BY REPEATED CRYPTOSPORIDIUM INFECTION IN IMMUNOSUPPRESSED MICE

483 IMMUNO-HISTOCHEMICAL CHANGES TRIGGERED BY REPEATED CRYPTOSPORIDIUM INFECTION IN IMMUNOSUPPRESSED MICE By MENNAT EL-RAHMAN A. FAHMY, HEBAT-ALLAH SALAH A. YOUSOF, SHAIMAA H. EL-SAYED, SOHEIR S. MAHMOUD, MONA MAGDY, MAISA A. SHALABY AND MOUSA A. M. ISMAIL Department of Medical Parasitology, Theodor Bilharz Research Institute, Imbaba, P.O. Box 30 Giza, Department of Medical Parasitology, Kasr Al-Ainy Faculty of Medicine, Cairo University, P.O. Box 11562 Cairo, Department of Medical Parasitology, Faculty of Medicine, Helwan University, and Department of Pathology, Theodor Bilharz Research Institute, Imbaba, P. O. Box 30 Giza, Egypt. (*Correspondence: drhebasalah@kasralainy.edu.eg, drhebasalah@hotmail.com) Abstract Cancers are increasing at an alarming rate with a potential association between parasitosis and cancer. This study was conducted on 190 albino mice to evaluate the possible histopathological changes and immunohistochemical alteration in the expression of β-catenin and p53 as markers of cellular proliferation in ileocecal region induced by chronic irritation with Cryptosporidium oocysts. 180 experimentally immunosuppressed mice were divided into five groups, control noninfected, infected with 50 oocysts/mouse once, infected with 500 oocysts/mouse once, repeatedly infected with 50 oocysts/mouse/week and repeatedly infected with 500 oocysts/ mouse/week. Each group was further subdivided into 3 subgroups according to the date designed for scarification. 10 naïve mice were used as negative control. Histopathological examination of the ileocecal region showed mild to severe villous atrophy and inflammatory exudation in colonic mucosa. Mice received high inoculum dose showed significantly severe histopathological changes. A progressive increase of cytoplasmic labeling of β-catenin without loss of β-catenin membrane labeling was recorded in groups infected once, in repeatedly infected ones; there was loss of βcatenin membrane labeling and progressive increase of the cytoplasmic labeling of β-catenin without nuclear expression of β-catenin or nuclear expression of p53 in all infected groups.
General assessment of the macroeconomic situation

10 Summary ● Growth is projected to remain modest by past norms, and unemployment is set to stay much above pre-crisis levels in many economies. Prospects for moderate improvements differ across both advanced and emerging economies. – In the advanced economies, growth is set to be stronger in the United States and the United Kingdom than in the euro area and Japan. Unemployment will remain particularly high in the euro area. – In the emerging market economies, growth will edge down in China, remain weak in Russia and Brazil, but will recover steadily in India, Indonesia and South Africa. ● World trade growth is expected to pick up a bit, with trade intensity growing again after the stagnation in recent years, but at a slower rate than prior to the crisis. ● Risks to GDP growth in the coming two years are on the downside due to potential financial volatility, lack of confidence about future growth prospects, and impaired and stretched balance sheets of banks and households. The euro area is particularly strongly exposed to these negative risks. ● Inflation is likely to remain below target in many OECD economies due to persistent slack and the recent sharp falls in oil and food prices, even if the latter will cushion growth. The euro area is at risk of deflation if growth stagnates or if inflation expectations fall further. ● If demand does not pick up as projected, some economies, notably the euro area, could get stuck in persistent stagnation, with demand weakness undermining potential growth, which in turn would have adverse effects on the ability of macroeconomic policy to support aggregate demand. ● Against this backdrop, it is essential that all macroeconomic and structural policy levers be used to offer as much support to growth as possible: – Ambitious structural reforms are urgently needed, particularly in Japan and the core countries in the euro area, in order to boost employment and strengthen long-term potential growth. Reforms fostering private and public investment would also give rise to positive short-term effects on demand. – Monetary policy requirements will diverge across countries: the United States and the United Kingdom are likely to start reducing monetary stimulus next year, while further stimulus is needed in the euro area and, as already decided, in Japan. These differences will inevitably result in volatility in debt and foreign exchange markets, and may uncover excesses in advanced and, …
Systematic Proteomics Analysis of Colorectal Cancer: to Recognize Potential Biomarkers and Remedial Target

BackgroundColorectal Cancer (CRC) is a high prevalence malignant of the digestive system. Notwithstanding huge investigation, the precise involved mechanisms are still blunted. It emerges that more research is needed to understand the underlying mechanisms of CRC better. In this investigation, a systems biology method was applied to provide a comprehensive insight through making a multilayer network to recognize novel biomarkers and potential drug targets.MethodTo identify the affected proteins in this disease, an existing protein expression profile on CRC was attained from ProteomeXchange. In the first step, the quality of the dataset was assessed, and then differentially expressed proteins (DEPs) were recognized based on FDR<0.05 as the statistically significant threshold. Subsequently, all identified DEPs were subjected to further enrichment analysis for finding the involved biomedical phenomena. In the following action, lncRNAs and miRNAs related to DEPs were predicted as regulatory layers via Cytoscape to make an integrative network.ResultThe empirical findings in this study indicated that the identified DEPs were mainly associated with two biomedical terms, such as “Mitochondrial dysfunction” and “Extracellular matrix organization. ” Additionally, several hub molecules were introduced in the constructed multilayer network, hub-DEPs (ITGB1, ACTG1, .), hub-miRs (miR-16-5p, miR-26b-5p, .), and hub-lncRNAs (KCNQ1OT1, NEAT1, …) that Can be deemed as a potential biomarker in the pathogenesis of CRC, further research should concentrate on the investigation of their role in CRC development.ConclusionThe attained results of this study may be paving a way to provide a deeper understanding of the vaguely involved mechanisms through an integrative insight into the interaction of proteins with regulatory layers.
Sibling Comparison Studies

Unmeasured confounding is one of the main sources of bias in observational studies. A popular way to reduce confounding bias is to use sibling comparisons, which implicitly adjust for several factors in the early environment or upbringing without requiring them to be measured or known. In this article we provide a broad exposition of the statistical analysis methods for sibling comparison studies. We further discuss a number of methodological challenges that arise in sibling comparison studies. Expected final online publication date for the Annual Review of Statistics and Its Application, Volume 9 is March 2022. Please see http://www.annualreviews. org/page/journal/pubdates for revised estimates.
CHARACTERIZATION OF TRANSVERSE CYLINDRICAL CAVITIES IN WOODEN BLOCKS OF THE SPECIES Cedrela odorata USING NON-DESTRUCTIVE ULTRASOUND TESTS

The main objective of the present work was to characterize the transverse cylindrical cavities of Cedrela odorata wood blocks using the non-destructive ultrasound techniques (NDT). The dispersions of acoustic wave propagation velocity (AWV) were measured and, considering the anisotropic structure of the wood, the Hankinson model was used for modeling with 2D graphics. The results showed strong dispersion in the frontal direction depending on the diameter of the cavities, in addition to good linear relationships between them for the cavity axis. Therefore, the results support the use of NDT ultrasound techniques to assess deteriorated structural elements such as historical monuments.
The Characteristics of Mortality Predictor Scoring for Sepsis Patients in Haji Adam Malik Hospital

Introduction: Sepsis is a leading cause of death in the Intensive Care Unit (ICU) in developed countries and its incidence is increasing. Many scoring systems are used to assess the severity of disease in patients admitted to the ICU. SOFA score to assess the degree of organ dysfunction in septic patients. The Acute Physiology and Chronic Health Evaluation II (APACHE II) scoring system is most often used for patients admitted to the ICU. CCI scoring system to assess the effect of comorbid disease in critically ill patients on mortality. The study aimed to describe the characteristics of the use of scoring to predict patients’ mortality admitted to Haji Adam Malik Hospital. Methods: This is an observational study with a cross-sectional design. A total of 299 study subjects met the inclusion criteria and exclusion criteria, three types of scoring, namely SOFA score, APACHE II score, and CCI score were used to assess the prognosis of septic patients. Data analysis was performed using SPSS. P-value <0.05 was considered statistically significant. Results: A total of 252 people (84.3%) of sepsis patients died. The mean age of the septic patients who died was 54.25 years. The SOFA score ranged from 0-24, the median SOFA score in deceased sepsis patients was 5.0. The APACHE II score ranged from 0-71, the median APACHE II score in deceased sepsis patients was 23.0. The CCI score ranged from 0-37, the median CCI score in deceased sepsis patients was 5.0. Conclusion: Higher scores are associated with an increased probability of death in septic patients. Keywords: Sepsis; mortality predictor; SOFA score; APACHE II score, CCI score.
Placement of inertial measurement units in Racket Sports: Perceptions of coaches for IMU use during training and competition.

While inertial measurement units (IMU) have become an integral part of sports performance analysis, upper body-mounted IMUs have been found to exhibit poor reliability in measuring lower-limb loading. In racket sports, IMUs have been placed in a number of positions on the upper body, lower body and racket in a research setting. A potential limitation to the concurrent use of multiple IMUs is that coaches may be reluctant to allow their athletes to wear the units during training and competition due to concerns that the units would interfere with athlete movement. This study seeks to understand the perceptions of racket sports coaches towards the use of IMUs in training and competition. A total of 58 racket sport coaches responded to a survey on the use of IMUs during training and competition. Based on the responses, 96.6% (56 out of 58) of coaches indicated that they would allow their athletes to wear IMUs in training, while 65.5% (38 out of 58) would allow their athletes to wear IMUs during competition. For use in training, 9 of the 14 suggested IMU placements received significant positive responses. However, none of the suggested IMU placements received significant positive responses for use during competition and 11 of the 14 received significant negative responses. This suggests that coaches understand the benefits of collecting data from IMUs during competition there remains concern regarding inconvenience to the athlete, lack of comfort, and appearance. Despite this, for use in training, a number of upper and lower bodymounted IMUs placements have the potential to be part of regular monitoring in racket sports.
Prediction of Mechanical Properties of Artificially Weathered Wood by Color Change and Machine Learning

Color parameters were used in this study to develop a machine learning model for predicting the mechanical properties of artificially weathered fir, alder, oak, and poplar wood. A CIELAB color measuring system was employed to study the color changes in wood samples. The color parameters were fed into a decision tree model for predicting the MOE and MOR values of the wood samples. The results indicated a reduction in the mechanical properties of the samples, where fir and alder were the most and least degraded wood under weathering conditions, respectively. The mechanical degradation was correlated with the color change, where the most resistant wood to color change exhibited less reduction in the mechanical properties. The predictive machine learning model estimated the MOE and MOR values with a maximum R2 of 0.87 and 0.88, respectively. Thus, variations in the color parameters of wood can be considered informative features linked to the mechanical properties of small-sized and clear wood. Further research could study the effectiveness of the model when analyzing large-sized timber.
Implications of COVID‐19 Regulations for People With Visual and Intellectual Disabilities: Lessons to Learn From Visiting Restrictions

Abstract Background Due to the COVID‐19 pandemic, governments of many countries announced regulations to prevent the virus from spreading. For people with a disability living in a sheltered care facility in the Netherlands, this meant that they were not able to receive any visitors for almost 3 months. Aim This study examines how people with an intellectual and visual disability and their families experienced the period in which it was mandated not to have any physical contact. The aim is to examine the experiences of this target group and gain insight in the way measures were taken in order to be able to advise care organizations about adequate care with respect to possible restrictive measures in the future. Methods In‐depth interviews were conducted with two groups of people: (1) fourteen people with an intellectual and visual disability, living in sheltered care facilities and (2) twelve people being relatives of residents of these same sheltered care facilities. In the interviews, the participants were questioned about their experiences with respect to the adjusted visiting regulations and with respect to the relation with their family during this period. A thematic analysis was performed first separately and then combined. Results and Discussion A number of themes resulted from the analysis that were related to (1) the instructed regulations of the sheltered care facilities and the government; (2) the relation with family and friends; and (3) the consequences of COVID‐19 and the regulations. Both relatives and residents were understanding of the difficult situation, but also expressed criticism about the chosen regulations, the communication thereof, and the practical implementation. Both groups have experienced the interruption of close contact as emotional and difficult. However, also positive consequences of the restrictions due to COVID‐19 were mentioned. The results provide a list of recommendations for sheltered care facilities.
Social-cognition and dog-human interactions: Is there potential for therapeutic-interventions for the disability sector?

Abstract The notion that dog-human interactions have the potential to mitigate impacts concerning the delay of typical development of social skills in humans is a novel concept. Research evidence concerning three aspects of social-cognition: sensory perception of social-cues, theory of mind and learning social-schemas, were reviewed with the scope to explore this notion. Literature from two different fields of research inquiry: animal-behaviour and neuroscience, was evaluated. Emerging from the animal-behavioural studies’ review was that aspects of dog behaviour could be a functional analogue of human behaviour (e.g. perception of social-cues). Neuroscience research theories concerning the functional role of the mirror neuron system in social-cognition in humans were evaluated against evidence from animal-behavioural studies investigating the relationship between dogs and children with socio-communicative developmental delays (e.g. vision impairment, Autism). It emerged that both fields of research suggested that through “embodied simulations” an alternative (e.g. to language and/or vision) approach to acquiring knowledge concerning the world of social interactions may be possible for individuals who present with developmental delays of social-competence. Within this context it is suggested that dog-human interactions may provide learning opportunities for development of social-competence in individuals with vision impairment. Implications for practice for the disability sector and specific examples for professionals who work with individuals who have vision impairment and assistance/therapy dogs are discussed.
The value(s) of social media rituals: a cross-cultural analysis of New Year’s resolutions

ABSTRACT New Year’s resolutions are acts of valuation where people express ideas about what is important and worthwhile in life. Although resolutions have a long history, the twenty-first century has transformed the practice into a social media ritual with greater visibility, interactivity, and reach. Using this unique event to explore the globalization of values, we analyze tweets about New Year’s resolutions in English, German, Italian, Japanese, and Korean. Combining network analysis (n = 160,592) and content analysis (n = 2000), we compare discursive topics, modes of ritual participation, and the values expressed in resolutions. Our findings indicate both that the ritual crosses cultures and that there are language-specific dynamics that do not map neatly onto established divisions between ‘Eastern’ and ‘Western’ value orientations. Instead, we identify three underlying tensions organizing the articulation of values: self-acceptance vs. self-improvement, public vs. private, and conformity vs. oppositionality. We discuss these in relation to an overarching tension between local contexts and global platform cultures. Finally, we explore the study’s broader implications for understanding the interaction between values, norms, and global communicative practices.
SARS-CoV-2 Serology Testing in an Asymptomatic, At-Risk Population: Methods, Results, Pitfalls

The primary aim of this study was to determine the seroprevalence of SARS-CoV-2 antibodies in a population of pediatric healthcare workers (HCWs). This study was conducted 14 May–13 July 2020. Study participants included pediatric HCWs at a pediatric hospital with either direct patient contact or close proximity to patient-care areas. SARS-CoV-2 antibodies were assessed via the Wytcote Superbio SARS-CoV-2 IgM/IgG Antibody Fast Detection Kit and the Abbott Architect SARS-CoV-2 IgG assay. Participants underwent RT-PCR testing upon entry to the study and following rapid IgM+/IgG+ results; respiratory panel PCR (RP-PCR) was performed following IgM+ results. A total of 57 of 289 (19.7%) of participants demonstrated positive serology as assessed by the Wytcote rapid kit (12 on Day 1 and 45 throughout the study). However, only one of these participants demonstrated IgG+ serology via the Abbott assay. Two participants tested SARS-CoV-2+ via RT-PCR testing. One individual was adenovirus+ and enterovirus/rhinovirus+. In our study population, we observed a seroprevalence of SARS-CoV-2 antibodies of 0.35%. The lack of concordance between antibody tests suggests that the Wytcote rapid test kit may not be of use as a screening tool. However, the feasibility of the overall process indicates that a similar methodology may have potential for future epidemiologic surveillance.
Inhibition of ATR prevents macropinocytosis driven retraction of neurites and opposes invasion in GBM

Glioblastoma (GBM) is the most common and aggressive type of primary brain tumour and remains incurable despite decades of research. GBM are characterised by highly infiltrative growth patterns that contribute to the profound cognitive and neurological symptoms experienced by patients, and to inevitable recurrence following treatment. Novel treatments that reduce infiltration of the healthy brain have potential to ameliorate clinical symptoms and improve survival. Here, we report a novel role of the Ataxia telangiectasia and Rad 3 related kinase (ATR) in supporting the invasive properties of GBM cells through the regulation of macropinocytosis-driven internalisation of integrin adhesion receptors. We demonstrate that inhibition of ATR opposes GBM migration in vitro, and correspondingly reduces infiltrative behaviour in orthotopic mouse models. These results indicate that ATR inhibition, in addition to its use as a radiosensitiser, may be effective in reducing GBM infiltration and its associated symptoms.
Effect of Fermentation Parameters on Natto and Its Thrombolytic Property

Natto is a popular food because it contains a variety of active compounds, including nattokinase. Previously, we discovered that fermenting natto with the combination of Bacillus subtilis GUTU09 and Bifidobacterium animalis subsp. lactis BZ25 resulted in a dramatically better sensory and functional quality of natto. The current study further explored the effects of different fermentation parameters on the quality of natto fermented with Bacillus subtilis GUTU09 and Bifidobacterium BZ25, using Plackett–Burman design and response surface methodology. Fermentation temperature, time, and inoculation amount significantly affected the sensory and functional qualities of natto fermented with mixed bacteria. The optimal conditions were obtained as follows: soybean 50 g/250 mL, triangle container, 1% sucrose, Bacillus subtilis GUTU09 to Bifidobacterium BZ25 ratio of 1:1, inoculation 7%, fermentation temperature 35.5 °C, and fermentation time 24 h. Under these conditions, nattokinase activity, free amino nitrogen content, and sensory score were increased compared to those before optimization. They were 144.83 ± 2.66 FU/g, 7.02 ± 0.69 mg/Kg and 82.43 ± 5.40, respectively. The plate thrombolytic area and nattokinase activity both increased significantly as fermentation time was increased, indicating that the natto exhibited strong thrombolytic action. Hence, mixed-bacteria fermentation improves the taste, flavor, nattokinase activity, and thrombolysis of natto. This research set the groundwork for the ultimate manufacturing of natto with high nattokinase activity and free amino nitrogen content, as well as good sensory and thrombolytic properties.