Miracle-dz/UniFAR-FTUs huggingface dataset:
Unravelling Contributions of Astrocytic Connexin 43 to the Functional Activity of Brain Neuron–Glial Networks under Hypoxic State In Vitro

Brain hypoxia remains an Achilles’ heel for public health that must be urgently addressed. Hypoxic damage affects both neurons and glial cells, particularly astrocytes, which are in close dynamic bi-directional communication, and are organized in plastic and tightly regulated networks. However, astroglial networks have received limited attention regarding their influence on the adaptive functional rearrangements of neural networks to oxygen deficiency. Herein, against the background of astrocytic Cx43 gap junction blockade by the selective blocker Gap19, we evaluated the features of spontaneous calcium activity and network characteristics of cells in primary cultures of the cerebral cortex, as well as the expression levels of metabotropic glutamate receptors 2 (mGluR2) and 5 (mGluR5) in the early and late periods after simulated hypoxia in vitro. We showed that, under normoxic conditions, blockade of Cx43 leads to an increase in the expression of metabotropic glutamate receptors mGluR2 and mGluR5 and long-term modulation of spontaneous calcium activity in primary cortical cultures, primarily expressed in the restructuring of the functional architectonics of neuron–glial networks through reducing the level of correlation between cells in the network and the percentage of existing correlated connections between cells. Blocking Cx43 during hypoxic injury has a pronounced neuroprotective effect. Together with the increased expression of mGluR5 receptors, a decrease in mGluR2 expression to the physiological level was found, which suggests the triggering of alternative molecular mechanisms of cell adaptation to hypoxia. Importantly, the blockade of Cx43 in hypoxic damage contributed to the maintenance of both the main parameters of the spontaneous calcium activity of primary cortical cultures and the functional architectonics of neuron–glial networks while maintaining the profile of calcium oscillations and calcium signal communications between cells at a highly correlated level. Our results demonstrate the crucial importance of astrocytic networks in functional brain adaptation to hypoxic damage and could be a promising target for the development of rational anti-hypoxic therapy.
Strategies for an accurate determination of the X(3872) energy from QCD lattice simulations

We develop a method to determine accurately the binding energy of the X(3872) from lattice data for the D ¯ Dinteraction. We show that, because of the small difference between the neutral and charged components of the X(3872), it is necessary to differentiate them in the energy levels of the lattice spectrum if one wishes to have a precise determination of the the binding energy of the X(3872). The analysis of the data requires the use of coupled channels. Depending on the number of levels available and the size of the box we determine the precision needed in the lattice energies to finally obtain a desired accuracy in the binding energy. PACS numbers:
Liquid Biopsy: A Multi-Parametric Analysis of Mutation Status, Circulating Tumor Cells and Inflammatory Markers in EGFR-Mutated NSCLC

The liquid biopsy has the potential to improve patient care in the diagnostic and therapeutic setting in non-small cell lung cancer (NSCLC). Consented patients with epidermal growth factor receptor (EGFR) positive disease (n = 21) were stratified into two cohorts: those currently receiving EGFR tyrosine kinase inhibitor (TKI) therapy (n = 9) and newly diagnosed EGFR TKI treatment-naïve patients (n = 12). Plasma genotyping of cell-free DNA was carried out using the FDA-approved cobas® EGFR mutation test v2 and compared to next generation sequencing (NGS) cfDNA panels. Circulating tumor cell (CTC) numbers were correlated with treatment response and EGFR exon 20 p.T790M. The prognostic significance of the neutrophil to lymphocyte ratio (NLR) and lactate dehydrogenase (LDH) was also investigated. Patients in cohort 1 with an EGFR exon 20 p.T790M mutation progressed more rapidly than those with an EGFR sensitizing mutation, while patients in cohort 2 had a significantly longer progression-free survival (p = 0.04). EGFR exon 20 p.T790M was detected by liquid biopsy prior to disease progression indicated by computed tomography (CT) imaging. The cobas® EGFR mutation test detected a significantly greater number of exon 20 p.T790M mutations (p = 0.05). High NLR and derived neutrophil to lymphocyte ratio (dNLR) were associated with shorter time to progression and worse survival outcomes (p < 0.05). High LDH levels were significantly associated with shorter time to disease progression (p = 0.03). These data support the use of liquid biopsy for monitoring EGFR mutations and inflammatory markers as prognostic indicators in NSCLC.
BEYOND THE MAIN SEQUENCE: TESTING THE ACCURACY OF STELLAR MASSES PREDICTED BY THE PARSEC EVOLUTIONARY TRACKS

Characterizing the physical properties of exoplanets and understanding their formation and orbital evolution requires precise and accurate knowledge of their host stars. Accurately measuring stellar masses is particularly important because they likely influence planet occurrence and the architectures of planetary systems. Single main-sequence stars typically have masses estimated from evolutionary tracks, which generally provide accurate results due to their extensive empirical calibration. However, the validity of this method for subgiants and giants has been called into question by recent studies, with suggestions that the masses of these evolved stars could have been overestimated. We investigate these concerns using a sample of 59 benchmark evolved stars with model-independent masses (from binary systems or asteroseismology) obtained from the literature. We find very good agreement between these benchmark masses and the ones estimated using evolutionary tracks. The average fractional difference in the mass interval ∼0.7–4.5 M⊙ is consistent with zero (−1.30 ± 2.42%), with no significant trends in the residuals relative to the input parameters. A good agreement between model-dependent and -independent radii (−4.81 ± 1.32%) and surface gravities (0.71 ± 0.51%) is also found. The consistency between independently determined ages for members of binary systems adds further support for the accuracy of the method employed to derive the stellar masses. Taken together, our results indicate that determination of masses of evolved stars using grids of evolutionary tracks is not significantly affected by systematic errors, and is thus valid for estimating the masses of isolated stars beyond the main sequence.
Moment transport equations for the primordial curvature perturbation

In a recent publication, we proposed that inflationary perturbation theory can be reformulated in terms of a probability transport equation, whose moments determine the correlation properties of the primordial curvature perturbation. In this paper we generalize this formulation to an arbitrary number of fields. We deduce ordinary differential equations for the evolution of the moments of ζ on superhorizon scales, which can be used to obtain an evolution equation for the dimensionless bispectrum, fNL. Our equations are covariant in field space and allow identification of the source terms responsible for evolution of fNL. In a model with M scalar fields, the number of numerical integrations required to obtain solutions of these equations scales like O(M3). The performance of the moment transport algorithm means that numerical calculations with M 1 fields are straightforward. We illustrate this performance with a numerical calculation of fNL in Nflation models containing M ~ 102 fields, finding agreement with existing analytic calculations. We comment briefly on extensions of the method beyond the slow-roll approximation, or to calculate higher order parameters such as gNL.
An Approximate Evaluation of BER Performance for Downlink GSVD-NOMA with Joint Maximum-likelihood Detector

 Generalized Singular Value Decomposition (GSVD) is the enabling linear precoding scheme for multiple-input multiple-output (MIMO) non-orthogonal multiple access (NO-MA) systems. In this paper, we extend research concerning downlink MIMO-NOMA systems with GSVD to cover bit error rate (BER) performance and to derive an approximate evaluation of the average BER performance. Specifically, we deploy, at the base station, the well-known technique of joint-modulation to generate NOMA symbols and joint maximum-likelihood (ML) to recover the transmitted data at end user locations. Consequently, the joint ML detector offers almost the same performance, in terms of average BER as ideal successive interference cancellation. Next, we also investigate BER performance of other pre-coding schemes, such as zero-forcing, block diagonalization, and simultaneous triangularization, comparing them with GSVD. Furthermore, BER performance is verified in different configurations in relation to the number of antennas. In cases where the number of transmit antennas is greater than twice the number of receive antennas, average BER performance is superior.
Classification of magnons in rotated ferromagnetic Heisenberg model and their competing responses in transverse fields

Competing orders is a general concept to describe various quantum phases and transitions in various materials. One efficient way to investigate competing orders is to first classify different class of excitations in a given quantum phase, then study their competing responses under various external probes. This strategy may not only lead to deep understanding of the quantum phase itself, but also its deep connections to various other quantum phases nearby. We implement this approach by studying the Rotated Ferromagnetic Heisenberg model (RFHM) in two different transverse fields $h_x$ and $h_z$ which can be intuitively visualized as studying spin-orbit couplings (SOC) effects in 2d Ising or anisotropic XY model in a transverse field. At a special SOC class, it was known that the RFHM at a zero field owns an exact ground state called Y-x state. It supports non only the commensurate C-C$_0$ and C-C$_{\pi} $ magnons, but also the in-commensurate C-IC magnons. These magnons are non-relativistic, not contained in the exact ground state, so need to be thermally excited. Their dramatic response under the longitudinal $ h_y $ field was recently worked out by the authors. Here we find they respond very differently under the two transverse fields. Any $h_x$ ($h_z$) changes the collinear Y-x state to a canted co-planar YX-x (YZ-x) state which suffers quantum fluctuations. The C-C$_0$, C-C$_{\pi} $ and C-IC magnons sneak into the quantum ground state, become relativistic and play leading roles even at $ T=0 $. We map out the boundaries among the C-C$_0$, C-C$_{\pi} $ and C-IC magnons, especially the detailed evolution of the C-IC magnons inside the canted phases. As $h_x$ ($h_z$) increases further, the C-C$_0$ magnons always win the competition and emerge as the seeds to drive a transition from the YX-x (YZ-x) to the X-FM ( Z-FM ) which is shown to be in the 3d Ising universality class.
The Hobby-Eberly Telescope Dark Energy Experiment (HETDEX): Description and Early Pilot Survey Results

The Hobby-Eberly Telescope Dark Energy Experiment (HETDEX) will outfit the 10 m HET with a new wide field and an array of 150 integral-field spectrographs to survey a 420 sq. deg. area in the north Galactic cap. Each fiber-coupled unit spectrograph will cover 350-550 nm, simultaneously. This instrument, called VIRUS, will produce ~34,000 spectra per exposure, and will open up the emission-line universe to large surveys for the first time. The survey will detect 0.8 million Lyman-alpha emitting (LAE) galaxies with 1.9<z<3.5 and more than a million [OII] emitting galaxies with z<0.5. The 3-D map of LAE galaxies in 9 cubic Gpc volume will be used to measure the expansion history at this early epoch using baryonic acoustic oscillations and the shape of the power spectrum. The aim of HETDEX is to provide a direct detection of dark energy at z~3. The measurement will constrain the evolution of dark energy and will also provide 0.1%-level accuracy on the curvature of the Universe, ten times better than current. The prototype of the VIRUS unit spectrograph (VIRUS-P) is a powerful instrument in its own right. Used on the McDonald 2.7 m, it covers the largest area of any integral field spectrograph, and reaches wavelengths down to 340 nm. VIRUS-P is being used for a pilot survey to better measure the properties of LAE galaxies in support of HETDEX. We report initial results from this survey.
Profile of Breast Cancer Patients with Radiotherapy in Hasan Sadikin Hospital Bandung

Background: Breast cancer is the most common cancer in women worldwide and in Indonesia. Most patients arrived at the hospital too late to receive the optimal benefit from breast cancer therapies, in which radiotherapy is one of the essential modalities. Radiotherapy is conducted as a local control by using the principle of ionizing radiation to eradicate the growth of cancer cells, hence reducing the chances of recurrence and enhancing survival rates. Some of the side effects include skin conditions that can manifest as redness and dry skin, fatigue, lymphedema, and chest wall fibrosis. Data and research on the profile of breast cancer patients with radiotherapy were still limited in Indonesia, particularly in West Java. This study aimed to assess the profile of breast cancer patients in Hasan Sadikin Hospital Bandung.Methods: This study was conducted with the retrospective descriptive quantitative method. The sampling technique was total sampling using 280 medical records of breast cancer patients with radiotherapy from January 1, 2018, until December 31, 2019, which were registered in the Hospital-Based Cancer Registry at the Radiotherapy Department, Hasan Sadikin General Hospital.Results: Breast cancer patients undergoing radiotherapy were mostly in the 45–54 years age group (36.4%). The most common chief complaint was a lump in the breast (66.4%), particularly in the left breast (45.0%). About 22.5% of all patients arrived at a locally advanced stage and 30.7% at an advanced stage with bone metastasis (10.6%), histopathological subtype Invasive Carcinoma No Special Type (IC-NST) (81.1%), and molecular subtype luminal B (9.6%). The most widely performed therapies were total mastectomy surgery (16.1%), neoadjuvant chemotherapy (62.9%), and complete adjuvant radiotherapy (47.1%) with External Beam Radiotherapy (EBRT) method using LINAC (71.1%). Conclusions: Breast cancer is a health burden in Hasan Sadikin General Hospital and remains one of the national health priorities. Further evaluation of management and follow-up studies need to be done to improve the implementation of therapies for patients and reduce the incidence rate
Adsorption Behavior of Toxic Carbon Dichalcogenides (CX2; X = O, S, or Se) on β12 Borophene and Pristine Graphene Sheets: A DFT Study

The adsorption of toxic carbon dichalcogenides (CX2; X = O, S, or Se) on β12 borophene (β12) and pristine graphene (GN) sheets was comparatively investigated. Vertical and parallel configurations of CX2⋯β12/GN complexes were studied herein via density functional theory (DFT) calculations. Energetic quantities confirmed that the adsorption process in the case of the parallel configuration was more desirable than that in the vertical analog and showed values up to −10.96 kcal/mol. The strength of the CX2⋯β12/GN complexes decreased in the order CSe2 > CS2 > CO2, indicating that β12 and GN sheets showed significant selectivity for the CSe2 molecule with superb potentiality for β12 sheets. Bader charge transfer analysis revealed that the CO2⋯β12/GN complexes in the parallel configuration had the maximum negative charge transfer values, up to −0.0304 e, outlining the electron-donating character of CO2. The CS2 and CSe2 molecules frequently exhibited dual behavior as electron donors in the vertical configuration and acceptors in the parallel one. Band structure results addressed some differences observed for the electronic structures of the pure β12 and GN sheets after the adsorption process, especially in the parallel configuration compared with the vertical one. According to the results of the density of states, new peaks were observed after adsorbing CX2 molecules on the studied 2D sheets. These results form a fundamental basis for future studies pertaining to applications of β12 and GN sheets for detecting toxic carbon dichalcogenides.
Analytical and experimental characterization of a miniature calorimetric sensor in a pulsatile flow

The behaviour of a miniature calorimetric sensor, which is under consideration for catheter-based coronary-artery-flow assessment, is investigated in both steady and pulsatile tube flows. The sensor is composed of a heating element operated at constant power and two thermopiles that measure flow-induced temperature differences over the sensor surface. An analytical sensor model is developed, which includes axial heat conduction in the fluid and a simple representation of the solid wall, assuming a quasi-steady sensor response to the pulsatile flow. To reduce the mathematical problem, described by a two-dimensional advection–diffusion equation, a spectral method is applied. A Fourier transform is then used to solve the resulting set of ordinary differential equations and an analytical expression for the fluid temperature is found. To validate the analytical model, experiments with the sensor mounted in a tube have been performed in steady and pulsatile water flows with various amplitudes and Strouhal numbers. Experimental results are generally in good agreement with theory and show a quasi-steady sensor response in the coronary-flow regime. The model can therefore be used to optimize the sensor design for coronary-flow assessment.
Advance and prospects in constraining the Yukawa-type corrections to Newtonian gravity from the Casimir effect

We report stronger constraints on the parameters of Yukawa-type corrections to Newtonian gravity from measurements of the lateral Casimir force between sinusoidally corrugated surfaces of a sphere and a plate. In the interaction range from 1.6 to 14 nm the strengthening of previously known high confidence constraints up to a factor of $2.4\ifmmode\times\else\texttimes\fi{}{10}^{7}$ is achieved using these measurements. It is shown that the replacement of a plane plate with a corrugated one in the measurements of the normal Casimir force by means of an atomic force microscope would result in the strengthening of respective high confidence constraints on the Yukawa-type interaction by a factor of $1.1\ifmmode\times\else\texttimes\fi{}{10}^{12}$. The use of a corrugated plate instead of a plane plate in the experiment by means of a micromachined oscillator also leads to strengthening of the obtained constraints. We further obtain constraints on the parameters of Yukawa-type interaction from the data of experiments measuring the gradient of the Casimir pressure between two parallel plates and the gradient of the Casimir-Polder force between an atom and a plate. The obtained results are compared with the previously known constraints. The possibilities of how to further strengthen the constraints on non-Newtonian gravity are discussed.
Raman spectrum and optical extinction of graphene buffer layers on the Si-face of 6H-SiC

The buffer layer has been analysed by combined micro-Raman and micro-transmission experiments. The epitaxial graphene growth on the (0001) Si face of 6H-SiC substrates was tuned to get a mixed surface at the early stage of graphitization with i) bare SiC, ii) buffer layer and iii) in some localized areas small monolayers flakes on top of the buffer layer. These unique samples enabled to measure the Raman spectrum of the buffer layer (close to the Raman spectrum of a carbon layer with a significant percentage of sp3 bonds) and its corresponding relative extinction at 514.5 nm. The Raman spectrum of the buffer layer remains visible after the growth of one monolayer on top but, despite the relatively low absorption coefficient of graphene, the Raman intensity is strongly reduced (typically divided by 3). The buffer layer background will bias usual evaluations of the domain sizes based on the D/G integrated intensities ratio. Finally, several Raman maps show the excellent thickness uniformity and crystalline quality of the graphene monolayers and that they are subjected to a non uniform compressive strain with values comprised between -0.60% and -0.42%.
TYPE Ia SINGLE DEGENERATE SURVIVORS MUST BE OVERLUMINOUS

In the single-degenerate (SD) channel of a Type Ia supernovae (SNe Ia) explosion, a main-sequence (MS) donor star survives the explosion but it is stripped of mass and shock heated. An essentially unavoidable consequence of mass loss during the explosion is that the companion must have an overextended envelope after the explosion. While this has been noted previously, it has not been strongly emphasized as an inevitable consequence. We calculate the future evolution of the companion by injecting 2–6 × 1047 erg into the stellar evolution model of a 1 M☉ donor star based on the post-explosion progenitors seen in simulations. We find that, due to the Kelvin–Helmholtz collapse of the envelope, the companion must become significantly more luminous (10–103 L☉) for a long period of time (103–104 yr). The lack of such a luminous “leftover” star in the LMC supernova remnant SNR 0609–67.5 provides another piece of evidence against the SD scenario. We also show that none of the stars proposed as the survivors of the Tycho supernova, including Tycho G, could plausibly be the donor star. Additionally, luminous donors closer than ∼10 Mpc should be observable with the Hubble Space Telescope starting ∼2 yr post-peak. Such systems include SN 1937C, SN 1972E, SN 1986G, and SN 2011fe. Thus, the SD channel is already ruled out for at least two nearby SNe Ia and can easily be tested for a number of additional ones. We also discuss similar implications for the companions of core-collapse SNe.
Incidence and Clinical Characteristics of Anaerobic Bacteremia at a University Hospital in Hungary: A 5-Year Retrospective Observational Study

Strict anaerobes have been reported to account for 0.5–13% of episodes of bacteremia in the adult population, with a growing awareness among clinicians regarding anaerobic bacteremia, especially in patients with specific predisposing factors. The aim of our present study was to assess the incidence and clinical characteristics of anaerobic bacteremia during a 5-year period (2016–2020) at a tertiary care teaching hospital, and to compare our findings with other studies in Hungary. Overall, n = 160 strict anaerobes were detected, out of which, 44.4% (n = 71; 0.1% of positive blood cultures, 0.1/1000 hospitalizations, 3.3/100,000 patient days) were clinically significant, while Cutibacterium spp. accounted for 55.6% (n = 89) of isolates. Among relevant pathogens, the Bacteroides/Parabacteroides spp. group (32.4%; n = 23), Clostridium spp. (22.5%; n = 16) and Gram-positive anaerobic cocci (15.5%; n = 11) were the most common. The mean age of patients was 67.1 ± 14.1 years, with a male majority (59.2%; n = 42). A total of 38.0% of patients were affected by a malignancy or immunosuppression, while an abscess was identified in 15.5% of cases. A total of 74.7% (n = 53) of patients received antibiotics prior to blood culture sampling; in instances where antimicrobials were reported, anaerobic coverage of the drugs was appropriate in 52.1% (n = 37) of cases. The 30-day crude mortality rate was 39.4% (n = 28); age ≥ 75 years was a significant predictor of 30-day mortality (OR: 5.0; CI: 1.8–14.4; p = 0.003), while malignancy and immunosuppression, lack of anti-anaerobic coverage or female sex did not show a significant relationship with the mortality of these patients. Early recognition of the role played by anaerobes in sepsis and timely initiation of adequate, effective antimicrobial treatment have proven efficient in reducing the mortality of patients affected by anaerobic bacteremia.