Miracle-dz/UniFAR-FTUs huggingface dataset:
Synthesis of Copper Nanoparticles Stabilized with Organic Ligands and Their Antimicrobial Properties

In this work, we report the synthesis of copper nanoparticles (Cu NPs), employing the chemical reduction method in an aqueous medium. We used copper sulfate pentahydrate (CuSO4·5H2O) as a metallic precursor; polyethylenimine (PEI), allylamine (AAM), and 4-aminobutyric acid (AABT) as stabilizing agents; and hydrated hydrazine as a reducing agent. The characterization of the obtained nanoparticles consisted of X-ray, TEM, FTIR, and TGA analyses. Through these techniques, it was possible to detect the presence of the used stabilizing agents on the surface of the NPs. Finally, a zeta potential analysis was performed to differentiate the stability of the nanoparticles with a different type of stabilizing agent, from which it was determined that the most stable nanoparticles were the Cu NPs synthesized in the presence of the PEI/AAM mixture. The antimicrobial activity of Cu/PEI/AABT toward P. aeruginosa and S. aureus bacteria was high, inhibiting both bacteria with low contact times and copper concentrations of 50–200 ppm. The synthesis method allowed us to obtain Cu NPs free of oxides, stable to oxidation, and with high yields. The newly functionalized Cu NPs are potential candidates for antimicrobial applications.
Extracellular Vesicles and Thrombosis: Update on the Clinical and Experimental Evidence

Extracellular vesicles (EVs) compose a heterogenous group of membrane-derived particles, including exosomes, microvesicles and apoptotic bodies, which are released into the extracellular environment in response to proinflammatory or proapoptotic stimuli. From earlier studies suggesting that EV shedding constitutes a cellular clearance mechanism, it has become evident that EV formation, secretion and uptake represent important mechanisms of intercellular communication and exchange of a wide variety of molecules, with relevance in both physiological and pathological situations. The putative role of EVs in hemostasis and thrombosis is supported by clinical and experimental studies unraveling how these cell-derived structures affect clot formation (and resolution). From those studies, it has become clear that the prothrombotic effects of EVs are not restricted to the exposure of tissue factor (TF) and phosphatidylserines (PS), but also involve multiplication of procoagulant surfaces, cross-linking of different cellular players at the site of injury and transfer of activation signals to other cell types. Here, we summarize the existing and novel clinical and experimental evidence on the role and function of EVs during arterial and venous thrombus formation and how they may be used as biomarkers as well as therapeutic vectors.
Eco-Friendly Biosorbents Based on Microbial Biomass and Natural Polymers: Synthesis, Characterization and Application for the Removal of Drugs and Dyes from Aqueous Solutions

Pharmaceuticals and dyes are a very important part of the nonbiodegradable or hard biodegradable substances present in wastewater. Microorganisms are already known to be effective biosorbents, but the use of free microbial cells involves difficulties in their separation from effluents and limits their application in wastewater treatment. Thus, this study aimed to develop biosorbents by immobilizing Saccharomyces cerevisiae, Saccharomyces pastorianus and Saccharomyces pastorianus residual biomass on natural polymers (alginate and chitosan) and to evaluate the biosorptive potential for removal of pharmaceuticals and dyes from water. Six types of biosorbents were synthesized and characterized by Scanning Electron Microscopy and Fourier Transform Infrared Spectroscopy techniques and their biosorptive capacities for three drugs (cephalexin, rifampicin, ethacridine lactate) and two dyes (orange II and indigo carmine) were evaluated. The obtained results show that the removal efficiency depends on the polymer type used for the immobilization. In case of alginate the removal efficiency is between 40.05% and 96.41% for drugs and between 27.83% and 58.29% for dyes, while in the case of chitosan it is between 40.83% and 77.92% for drugs and between 17.17% and 44.77% for dyes. In general, the synthesized biosorbents proved to be promising for the removal of drugs and dyes from aqueous solutions.
Emerging Adult Antisocial Problems and Psychological and Physical Maltreatment: Moderation by Other Parent-Child Relationship Quality

Current research supports that both psychological/physical maltreatment by parents and parent-child relationship quality strongly correlate with children’s psychopathology. Less research has examined the interaction effects among these variables, especially in emerging adults. The current study analyzed the association between psychological/physical maltreatment experienced from one parent and antisocial behaviors displayed by emerging adults, as well as the moderating effect of the other parent’s parent-child relationship quality. This sample included 1,364 emerging adults (953 females, 411 males) who reported on past year psychological and physical maltreatment and parent-child relationship quality. Results indicated that, when considered together, parent-child relationship quality was a stronger predictor of emerging antisocial problems than maltreatment, with the exception of the father-son dyad. Additionally, overall findings suggested that having a high-quality relationship with one caregiver was associated with lower antisocial problems in the context of high maltreatment from the other caregiver. Nevertheless, there were deviations from this norm. Unexpectedly, the lowest antisocial problems in females were associated with higher levels of paternal physical maltreatment combined with higher levels of maternal parent-child relationship quality. Moreover, the combination of low paternal psychological maltreatment and low maternal relationship quality was associated with particularly high antisocial problems in males. It is important to note the findings in the context of this sample of college students, who could be considered an advantaged group relative to some others. Since our sample might not represent our entire population of interest, which is emerging adults, it is important for future studies to examine these relationships across more diverse emerging adults. Practical implications are discussed.
Can the Unified Theory of Acceptance and Use of Technology (UTAUT) Help Explain Subjective Well-Being in Senior Citizens due to Gateball Participation?

Promoting successful aging strategies through well-reasoned caregiving programs is, and should be, one of the main objectives of many government policies and their implementing agencies. Well-being has been considered an important indicator of successful aging. Leisure is a key life domain and a core ingredient for overall well-being. Yet, within well-being research, few studies have made the connection between leisure participation as accepted behavior and subjective well-being in senior citizens. This study proposed to examine the applicability of the Unified Theory of Acceptance and Use of Technology (UTAUT) in explaining senior citizens’ decision-making processes in terms of leisure participation behavior and the effect of such behavioral engagement on subjective well-being. The respondents were senior citizens in Taiwan who played gateball and were aged 60 years or older. A total of 595 usable responses were obtained and used to answer the research question. The empirical results indicate that performance expectancy, social influence, and facilitating conditions are positively and significantly related to senior citizens’ gateball participation behavior. In addition, gateball participation behavior had a positive and significant effect on respondents’ subjective well-being. The results of this study not only extend the application of UTAUT in terms of participation behavior in leisure activities, but also can provide gateball associations and government entities a theoretical model for developing and promoting gateball programs which serve or involve the elderly, as well as helping older adults to pursue satisfactory levels of wellbeing.
Supercritical Antisolvent Fractionation of Antioxidant Compounds from Salvia officinalis

The increasing interest towards greener antioxidants obtained via natural sources and more sustainable processes encourages the development of new theoretical and experimental methods in the field of those compounds. Two advanced separation methods using supercritical CO2 are applied to obtain valuable antioxidants from Salvia officinalis, and a first approximation to a QSAR model relating molecular structure with antioxidant activity is explored in order to be used, in the future, as a guide for the preselection of compounds of interest in these processes. Separation experiments through antisolvent fractionation with supercritical CO2 were designed using a Response Surface Methodology to study the effect of pressure and CO2 flow rate on both mass yields and capability to obtain fractions enriched in three antioxidant compounds: chlorogenic acid, caffeic acid and rosmarinic acid which were tracked using HPLC PDA. Rosmarinic acid was completely retained in the precipitation vessel while chlorogenic and caffeic acids, though distributed between the two separated fractions, had a major presence in the precipitation vessel too. The conditions predicted for an optimal overall yield and enrichment were 148 bar and 10 g/min. Although a training dataset including much more compounds than those now considered can be recommended, descriptors calculated from the σ-profiles provided by COSMO-RS model seem to be adequate for estimating the antioxidant activity of pure compounds through QSAR.
Dynamic Behavior of Rotation Transmission Nano-System in Helium Environment: A Molecular Dynamics Study

The molecular dynamics (MD) method is used to investigate the influence of the shielding gas on the dynamic behavior of the heterogeneous rotation transmission nano-system (RTS) built on carbon nanotubes (CNTs) and boron nitride nanotube (BNNT) in a helium environment. In the heterogeneous RTS, the inner CNT acts as a rotor, the middle BNNT serves as a motor, and the outer CNT functions as a stator. The rotor will be actuated to rotate by the motor due to the interlayer van der Waals effects and the end effects. The MD simulation results show that, when the gas density is lower than a critical range, a stable signal of the rotor will arise on the output and the rotation transmission ratio (RRT) of RTS can reach 1.0, but as the gas density is higher than the critical range, the output signal of the rotor cannot be stable due to the sharp drop of the RRT caused by the large friction between helium and the RTS. The greater the motor input signal of RTS, the lower the critical working helium density range. The results also show that the system temperature and gas density are the two main factors affecting the RTS transmission behavior regardless of the size of the simulation box. Our MD results clearly indicate that in the working temperature range of the RTS from 100 K to 600 K, the higher the temperature and the lower the motor input rotation frequency, the higher the critical working helium density range allows.
The adaptive challenge of extreme conditions shapes evolutionary diversity of plant assemblages at continental scales

Significance We explore an extended view of the tropical conservatism hypothesis to account for two often-neglected components of climatic stress: drought and the combined effect of seasonal cold and drought—the latter being a common feature of extratropical dry environments. We show that evolutionary diversity of angiosperm assemblages in extratropical dry biomes is even lower than in biomes subject to only one type of climatic stress. We further show that evolutionary diversity in many assemblages from eastern North America is higher or comparable to that of tropical moist forests, suggesting that some extratropical moist biomes have accumulated angiosperm lineages over deep evolutionary timescales with their flora assembled from lineages that represent the entirety of the angiosperm tree of life. The tropical conservatism hypothesis (TCH) posits that the latitudinal gradient in biological diversity arises because most extant clades of animals and plants originated when tropical environments were more widespread and because the colonization of colder and more seasonal temperate environments is limited by the phylogenetically conserved environmental tolerances of these tropical clades. Recent studies have claimed support of the TCH, indicating that temperate plant diversity stems from a few more recently derived lineages that are nested within tropical clades, with the colonization of the temperate zone being associated with key adaptations to survive colder temperatures and regular freezing. Drought, however, is an additional physiological stress that could shape diversity gradients. Here, we evaluate patterns of evolutionary diversity in plant assemblages spanning the full extent of climatic gradients in North and South America. We find that in both hemispheres, extratropical dry biomes house the lowest evolutionary diversity, while tropical moist forests and many temperate mixed forests harbor the highest. Together, our results support a more nuanced view of the TCH, with environments that are radically different from the ancestral niche of angiosperms having limited, phylogenetically clustered diversity relative to environments that show lower levels of deviation from this niche. Thus, we argue that ongoing expansion of arid environments is likely to entail higher loss of evolutionary diversity not just in the wet tropics but in many extratropical moist regions as well.
Simulation of the Mechanical Behaviour of Metal Gyroids for Bone Tissue Application

Additive manufacturing is a valid solution to build complex geometries, including lightweight structures. Among these, gyroids offer a viable concept for bone tissue application, although many preliminary trials would be required to validate the design before actual implantation. In this frame, this study is aimed at presenting the background and the steps to build a numerical simulation to extract the mechanical behaviour of the structure, thus reducing the experimental effort. The results of the simulation are compared to the actual outcome resulting from quasi-static compressive tests and the effectiveness of the model is measured with reference to similar studies presented in the literature about other lightweight structures.
Application of optic neuro‐ophthalmology imaging in latent meningeal metastases of lung cancer

Latent intracranial meningeal metastases (IMM) of lung cancer is difficult to determine, yet it is critical to do so given that it impacts the treatment agent. Studies on this disease are rare, thus necessitating further investigation. As a case study, we will explore the application of optic neuroimaging in IMM. A 62‐year‐old female patient was diagnosed with lung adenocarcinoma, which had progressed to osseous metastasis. During the course of chemotherapy, the patient had bilateral vision loss and paralysis of extraocular muscles. Ophthalmologists ruled out disease of the retina and suspected intracranial metastasis; however, brain‐enhanced magnetic resonance angiography and magnetic resonance venography were normal. Given the patient's severe osteoarthropathy and poor physical condition, she refused to undergo a lumbar puncture examination. Optic neuro‐ophthalmology imaging was ultimately used. Utilizing optical coherence tomography, we found that the basement membrane layer in the papilledema was protruding up towards the vitreous cavity. To assist in visualization, the optic nerve sheath was enhanced with optic magnetic resonance imaging. With these methods, the dural metastasis was identified, the treatment agent was changed for the patient, and she had a successful recovery. Thus, optic neuro‐ophthalmology imaging should be recommended for patients who are in the latent course of dural metastasis, and it could also be used to evaluate therapeutic efficacy.
Effects of dried apple peel powder on the rheological and sensory properties of drinking yogurt

EFFECTS OF DRIED APPLE PEEL ON THE RHEOLOGICAL AND SENSORY PROPERTIES OF DRINKING YOGURT Zening Zhou Advisor: University of Guelph, 2018 Dr. Gisèle LaPointe The study was undertaken to investigate the effect of commercial dried apple peel powder (CDAP) and Granny Smith dried apple peel powder (GSAP) addition on the rheological and sensory properties of drinking yogurt in order to develop a dietary fiber enriched drinking yogurt. The rheological study showed that drinking yogurt fortified with 3.2% CDAP and 4.0% GSAP were the best-fortified amounts for drinking yogurt with the same viscosity (50) and were further used to sensory evaluation. Consumer acceptance of drinking yogurt was evaluated using a 9-point consumer liking scale and a 5-point Just-About-Right scale. Consumers found that the 4.0% GSAP fortified drinking yogurt was acceptable while 3.2% CDAP fortified drinking yogurt was not accepted by consumers due to too dark color and grainy texture. These results suggest the possibility of utilizing dried apple peel powder as a dietary fiber enriched ingredient in drinking yogurt manufacture.
Innovative Culture and Firm Performance of Medical Device Companies: Mediating Effects of Investment in Education and Training

This research explored the mediating effect of investment in education and training relating to the innovative culture and organizational performance of medical device companies. We used the Human Capital Corporate Panel data provided by the Korea Vocational Competency Development Institute. In the industrial classification system of panel data, the industries related to medical devices were extracted and conclusively analyzed for 8629 workers and 368 companies. The independent and dependent variables were innovative culture and corporation performance, respectively. Investment in training and education was a mediating variable between the independent and dependent variables. Quantitative data were analyzed using SPSS software. A higher level of organizational satisfaction emerged in an innovative culture. Innovative culture positively affected organizational satisfaction. Further, investment in education and training to promote an innovative culture positively affected organizational satisfaction. Medical device companies should improve their performance by creating an innovative culture.
Professionals’ Expectations and Preparedness to Implement Knowledge-Based Palliative Care at Nursing Homes before an Educational Intervention: A Focus Group Interview Study

The provision of knowledge-based palliative care is rare in nursing homes. There are obstacles to practically performing this because it can be difficult to identify when the final stage of life begins for older persons. Educational interventions in palliative care in nursing homes are a challenge, and joint efforts are needed in an organisation, including preparedness. The aim was to explore professionals’ expectations and preparedness to implement knowledge-based palliative care in nursing homes before an educational intervention. This study has a qualitative focus group design, and a total of 48 professionals working in nursing homes were interviewed with a semi-structured interview guide. Qualitative content analysis with an inductive approach was used for the analysis. One major theme was identified: professionals were hopeful yet doubtful about the organisation’s readiness. The main categories of increased knowledge, consensus in the team, and a vision for the future illustrate the hopefulness, while insufficient resources and prioritisation illustrate the doubts about the organisation’s readiness. This study contributes valuable knowledge about professionals’ expectations and preparedness, which are essential for researchers to consider in the planning phase of an implementation study. The successful implementation of changes needs to involve strategies that circumvent the identified obstacles to organisations’ readiness.
Green Composite Sensor for Monitoring Hydroxychloroquine in Different Water Matrix

Hydroxychloroquine (HCQ), a derivative of 4-aminoquinolone, is prescribed as an antimalarial prevention drug and to treat diseases such as rheumatoid arthritis, and systemic lupus erythematosus. Recently, Coronavirus (COVID-19) treatment was authorized by national and international medical organizations by chloroquine and hydroxychloroquine in certain hospitalized patients. However, it is considered as an unproven hypothesis for treating COVID-19 which even itself must be investigated. Consequently, the high risk of natural water contamination due to the large production and utilization of HCQ is a key issue to overcome urgently. In fact, in Brazil, the COVID-19 kit (hydroxychloroquine and/or ivermectin) has been indicated as pre-treatment, and consequently, several people have used these drugs, for longer periods, converting them in emerging water pollutants when these are excreted and released to aquatic environments. For this reason, the development of tools for monitoring HCQ concentration in water and the treatment of polluted effluents is needed to minimize its hazardous effects. Then, in this study, an electrochemical measuring device for its environmental application on HCQ control was developed. A raw cork–graphite electrochemical sensor was prepared and a simple differential pulse voltammetric (DPV) method was used for the quantitative determination of HCQ. Results indicated that the electrochemical device exhibited a clear current response, allowing one to quantify the analyte in the 5–65 µM range. The effectiveness of the electrochemical sensor was tested in different water matrices (in synthetic and real) and lower HCQ concentrations were detected. When comparing electrochemical determinations and spectrophotometric measurements, no significant differences were observed (mean accuracy 3.0%), highlighting the potential use of this sensor in different environmental applications.
Loss Factor Behavior of Thermally Aged Magnetorheological Elastomers

Polymer composites have been widely used as damping materials in various applications due to the ability of reducing the vibrations. However, the environmental and surrounding thermal exposure towards polymer composites have affected their mechanical properties and lifecycle. Therefore, this paper presents the effect of material-temperature dependence on the loss factor and phase shift angle characteristics. Two types of unageing and aging silicone-rubber-based magnetorheological elastomer (SR-MRE) with different concentrations of carbonyl iron particles (CIPs), 30 and 60 wt%, are utilized in this study. The morphological, magnetic, and rheological properties related to the loss factor and phase shift angle are characterized using a low-vacuum scanning electron microscopy, and vibrating sample magnetometer and rheometer, respectively. The morphological analysis of SR-MRE consisting of 30 wt% CIPs revealed a smoother surface area when compared to 60 wt% CIPs after thermal aging due to the improvement of CIPs dispersion in the presence of heat. Nevertheless, the rheological analysis demonstrated inimitable rheological properties due to different in-rubber structures, shear deformation condition, as well as the influence of magnetic field. No significant changes of loss factor occurred at a low CIPs concentration, whilst the loss factor increased at a higher CIPs concentration. On that basis, it has been determined that the proposed changes of the polymer chain network due to the long-term temperature exposure of different concentrations of CIPs might explain the unique rheological properties of the unaged and aged SR-MRE.