Miracle-dz/UniFAR-FTUs huggingface dataset:
COPD_A_342220 245..258

1Pneumology Department, Hospital Universitari Vall d ́Hebron/Vall d’Hebron Institut de Recerca (VHIR), Vall d’Hebron Barcelona Hospital Campus, CIBER de Enfermedades Respiratorias (CIBERES), Barcelona, Spain; 2Centro de Salud Dra. Teresa Pique, Mallorca, Spain; 3Instituto de Investigación Sanitaria de las Islas Baleares (IdISBa), Mallorca, Spain; 4Boehringer Ingelheim España, Sant Cugat del Vallés, Barcelona, Spain; 5Syneos Health Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, USA; 6Department of Medicine and Medical Specialties, Universidad de Alcalá, Madrid, Spain; 7Pneumology Department, Hospital Universitario de Guadalajara, Guadalajara, Spain
Edinburgh Research Explorer Mindful movement and skilled attention

Bodily movement has long been employed as a foundation for cultivating mental skills such as attention, self-control or mindfulness, with recent studies documenting the positive impacts of mindful movement training, such as yoga and tai chi. A parallel “mind-body connection” has also been observed in many developmental disorders. We elaborate a spectrum of mindfulness by considering ADHD, in which deﬁcient motor control correlates with impaired (disinhibited) behavioral control contributing to deﬁning features of excessive distractibility and impulsivity. These data provide evidence for an important axis of variation for wellbeing, in which skillful cognitive control covaries with a capacity for skillful movement. We review empirical and theoretical literature on attention, cognitive control, mind wandering, mindfulness and skill learning, endorsing a model of skilled attention in which motor plans, attention, and executive goals are seen as mutually co-deﬁning aspects of skilled behavior that are linked by reciprocal inhibitory and excitatory connections. Thus, any movement training should engage “higher-order” inhibition and selection and develop a repertoire of rehearsed procedures that coordinate goals, attention and motor plans. However, we propose that mindful movement practice may improve the functional quality of rehearsed procedures, cultivating a transferrable skill of attention. We adopt Langer’s spectrum of mindful learning that spans from “mindlessness” to engagement with the details of the present task and contrast this with the mental attitudes cultivated in standard mindfulness meditation. We particularly follow Feldenkrais’ suggestion that mindful learning of skills for organizing the body in movement might transfer to other forms of mental activity. The results of mindful movement training should be observed in multiple complementary measures, and may have tremendous potential beneﬁt for individuals with ADHD and other populations. 1972). The advantage of an overt hand movement (as in the “motoric mind wandering” example) is that outside observers can also (categorically) detect when the student “wanders” (readers may verify this for themselves with the videos in the supplementary material). Novel movement instructions, particularly those that provide attentional challenges may additionally yield an initial feeling of awkwardness when doing a “lesson”, which may gradually reduce as the student improves. Feldenkrais speaks of ultimately becoming “elegant” in one’s movements, which may provide additional externally observable criteria for indexing gradual improvements during learning.
Infrared H2O Absorption in Massive Protostars at High Spectral Resolution: Full Spectral Survey Results of AFGL 2591 and AFGL 2136

We have performed a high-resolution 4–13 μm spectral survey of the hot molecular gas associated with the massive protostars AFGL 2591 and AFGL 2136. Here we present the results of the analysis of the ν 2 band of H2O, detected with the Echelon Cross Echelle Spectrograph on board the Stratospheric Observatory for Infrared Astronomy between wavelengths of 5 and 8 μm. All lines are seen in absorption. Rotation diagrams indicate that the gas is optically thick and lines are observed to saturate at 40% and 15% relative to the continuum for AFGL 2136 and AFGL 2591, respectively. We applied two curve of growth analyses to derive the physical conditions, one assuming a foreground origin and one a circumstellar disk origin. We find temperatures of 400–600 K. A foreground origin would require the presence of externally heated clumps that are smaller than the continuum source. The disk analysis is based on stellar atmosphere theory, which takes into consideration the temperature gradient in the disk. We discuss the challenges with each model, taking into consideration the properties of other species detected in the spectral survey, and conclude that further modeling efforts are required to establish whether the absorption has a disk or foreground origin. The main challenge to the foreground model is that molecules are expected to be observed in emission. The main challenges to the disk model are the midplane heating mechanism and the presence of narrow absorption lines shifted from the systemic velocity.
Timing Properties of the X-Ray Accreting Pulsar 1A 0535+262 Studied with Insight-HXMT

We report results on the timing analysis of the 2020 giant outburst of 1A 0535+262, using broadband data from Insight-HXMT. The analysis of the pulse profile evolution from the subcritical-luminosity to the supercritical-luminosity regime is presented for the first time. We found that the observed pulse profile exhibits a complex dependence on both energy and luminosity. A dip structure at the energy of the cyclotron resonant scattering features is found for the first time in the pulse fraction–energy relation of 1A 0535+262, when the outburst evolves in a luminosity range from 4.8 × 1037 to 1.0 × 1038 erg s−1. The observed structure is luminosity dependent and appears around the source critical luminosity (∼6.7 × 1037 erg s−1).
The ALPINE–ALMA [C ii] Survey: The Infrared–Radio Correlation and Active Galactic Nucleus Fraction of Star-forming Galaxies at z ∼ 4.4–5.9

We present the radio properties of 66 spectroscopically confirmed normal star-forming galaxies (SFGs) at 4.4 < z < 5.9 in the COSMOS field that were [C ii]-detected in the Atacama Large Millimeter/submillimeter Array Large Program to INvestigate [C ii] at Early times (ALPINE). We separate these galaxies (“C ii-detected-all”) into lower-redshift (“C ii-detected-lz”; 〈z〉 = 4.5) and higher-redshift (“C ii-detected-hz”; 〈z〉 = 5.6) subsamples, and stack multiwavelength imaging for each subsample from X-ray to radio bands. A radio signal is detected in the stacked 3 GHz images of the C ii-detected-all and lz samples at ≳3σ. We find that the infrared–radio correlation of our sample, quantified by q TIR, is lower than the local relation for normal SFGs at a ∼3σ significance level, and is instead broadly consistent with that of bright submillimeter galaxies at 2 < z < 5. Neither of these samples show evidence of dominant active galactic nucleus activity in their stacked spectral energy distributions (SEDs), UV spectra, or stacked X-ray images. Although we cannot rule out the possible effects of the assumed spectral index and applied infrared SED templates in causing these differences, at least partially, the lower obscured fraction of star formation than at lower redshift can alleviate the tension between our stacked q TIRs and those of local normal SFGs. It is possible that the dust buildup, which primarily governs the infrared emission, in addition to older stellar populations, has not had enough time to occur fully in these galaxies, whereas the radio emission can respond on a more rapid timescale. Therefore, we might expect a lower q TIR to be a general property of high-redshift SFGs.
Density and Refractive Index of Carbon Monoxide Ice at Different Temperatures

This paper is intended to study the density and the refractive index of the solid carbon monoxide in the interval 13–28 K to improve our understanding of the dynamics in the astrophysical environments where they are present. A series of deposition experiments have been performed under high vacuum conditions to study the properties of this ice under astrophysical conditions. Ice density has been experimentally calculated at different deposition temperatures of astrophysical interest, which complement the scarce values present in the literature. The refractive index has also been experimentally determined. The data have been used to obtain an experimental relationship between refractive index and density. Values of density are necessary to interpret observations of astrophysical objects or to design irradiation experiments to understand how irradiation affects ices present in these objects. The experimental relationship found between density and refractive index allows us to estimate density from a known refractive index, even for temperatures not reached using our experimental setup.
Network Pharmacology-Based Approach to Investigate the Molecular Targets of Sinomenine for Treating Breast Cancer

Purpose: Sinomenine has been known to inhibit the proliferation of breast cancer cells. However, its targets have not been found yet. This study aimed to search for molecular targets of sinomenine for treating breast cancer via network pharmacology. Methods: Potential targets of sinomenine or breast cancer were separately screened from indicated databases. The common targets of both sinomenine and breast cancer were considered as the targets of sinomenine for treating breast cancer. A sinomenine-target-pathway network was constructed based on the obtained results from Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis. The putative targets of sinomenine were further determined by using protein–protein interaction (PPI) analysis and molecular docking. Finally, the putative targets were verified in vitro and in vivo. Results: Twenty predicted targets were identified through network pharmacological analysis. Gene Ontology (GO) and KEGG pathway enrichment indicated that these predicted targets enriched in the process of MAP kinase activity, VEGF signaling pathway, Relaxin signaling pathway, Growth hormone synthesis, secretion and action. MAPK1, NOS3, NR3C1, NOS1 and NOS2 were further identified as the putative targets by using PPI and molecular docking analysis. Expression of MAPK1, NR3C1, NOS1, NOS2 and NOS3 genes were significantly regulated by sinomenine in both MCF-7 cells and MDA-MB-231 cells. Furthermore, the expression of NR3C1 in human breast cancer specimens was lower than that in para-tumor normal tissues. Meanwhile, the expression of NR3C1 in xenograft tumors was up-regulated after sinomenine treatment. Conclusion: MAPK1, NR3C1, NOS1, NOS2 and NOS3 were identified as the putative targets of sinomenine for treating breast cancer. NR3C1 was preliminarily confirmed as a target of sinomenine in two breast cancer cell lines, xenograft tumor models and human breast cancer specimens. These data indicated that the network pharmacology-based prediction of sinomenine targets for treating breast cancer could be reliable.
Coping style, social support and psychological distress in the general Chinese population in the early stages of the COVID-2019 epidemic CURRENT STATUS:

Background The purpose of this study was to investigate the psychological status of the general population in mainland China during the outbreak of coronavirus disease 2019 (COVID-19), and to explore the factors influencing psychological distress, in order to provide the basis for further psychological intervention programs. We administered three questionnaires on-line to a convenience sample of the general population from different regions of mainland China from February 1 to February 4, 2020. We used the Mandarin versions of the six-item Kessler psychological distress scale (K6), the Simplified Coping Style Questionnaire (SCSQ), and the Social Support Rating Scale (SSRS). We also collected demographic data and other information related to the COVID-19 outbreak. Multivariate binary logistic regression analysis was used to identify factors influencing psychological distress. using frequencies for categorical variables and mean values for odds ratios (ORs)
High voltage gain interleaved DC–DC converter with minimum current ripple

A new interleaved high step-up DC–DC converter is presented in this study which integrates coupled inductors and voltage multipliers techniques into interleaved structure to provide high voltage gain without extreme duty cycle. The voltage stress across power metal–oxide–semiconductor field-effect transistors is very low, so low voltage rating switches with lower R ds(on) can be used. A modified version of winding cross-coupled inductors technique is employed to minimise the input current ripple, and also the reverse recovery problem of the output diodes is alleviated because of the leakage inductance of the coupled inductors. Also, the leakage energy is absorbed and recycled to the output by the passive clamp scheme. In addition, automatic current sharing performance between the interleaved phases is established without any extra circuit. The operating principles of the proposed converter are explained and the theoretical analysis is provided, and in order to verify the effectiveness of the proposed converter, a 170 W, 30–360 V laboratory prototype is implemented.
Brucella abortus senses the intracellular environment through the 1 two-component system BvrR/BvrS allowing the adaptation to its 2 replicative niche 3

19 Brucella abortus is a facultative extracellular-intracellular pathogen belonging a group of 20 α-Proteobacteria that establishes close interactions with animal cells. This bacterium 21 enters host cells in a membrane bound compartment, avoiding the lysosomal route and 22 reaching the endoplasmic reticulum through the action of the Type IV secretion system, 23 VirB. In this work we demonstrate that the two-component system BvrR/BvrS senses 24 the intracellular environment to mount the transcriptional response required for 25 intracellular life adaptation. By combining a method to purify intracellularly extracted 26 bacteria with a strategy that allows direct determination of BvrR phosphorylation we 27 showed that upon entrance to host cells, the regulatory protein BvrR was activated 28 (BvrR-P) by phosphorylation at aspartate 58. This activation takes place in response to 29 intracellular cues found in early compartments, such as low pH and nutrient deprivation. 30 Furthermore, BvrR activation was followed by an increase in the expression of VjbR and 31 VirB. The in vitro activation of this BvrR-P/VjbR/VirB virulence circuit rescued B. abortus 32 from the inhibition of intracellular replication induced by bafilomycin treatment of cells, 33 demonstrating the relevance of this mechanism for the intracellular bacterial survival 34 and replication. Altogether, our results indicate that B. abortus senses the transition 35 from the extracellular to the intracellular milieu through BvrR/BvrS allowing the 36 bacterium to transit safely to its replicative niche. These results serve as a working 37 model for understanding the role of this family of two-component systems in the 38 adaptation to intracellular life of α-Proteobacteria. 39
Is the geﬁtinib plus trastuzumab combination feasible in breast cancer patients?

We have previously demonstrated that combined treatment of breast cancer cells that co-express epidermal growth factor receptor (EGFR) and ErbB-2 with the EGFR tyrosine kinase inhibitor (TKI) geﬁtinib plus trastuzumab results in a synergistic antitumor effect [1]. Similar ﬁndings have been obtained by independent research groups [2]. Following these results, a phase I/II clinical trial of trastuzumab plus geﬁtinib in breast cancer patients with ErbB-2 expressing tumors has been completed [3]. In the phase I study, patients were treated with trastuzumab (2 mg/kg/week) plus geﬁtinib at two dose levels, 250 and 500 mg/day. At the highest dose, two out of three patients developed grade 3 diarrhoea. Therefore, the phase II study was conducted using geﬁtinib 250 mg/day. Few responses were observed and only in previously untreated patients (two of 28), and time to progression appeared shorter than that previously reported with trastuzumab alone. These results led the investigators to con-clude that further use of combinations of trastuzumab plus EGFR-TKIs is not justiﬁed. We believe that the results of the phase II study could have been ﬂawed by the dose of geﬁtinib, 250 mg/day, lower than the 500 mg/day usually considered as full dose. In fact, equivalence of the 250 and 500 mg doses has been suggested by phase II trials of geﬁtinib in non-small-cell lung cancer, a disease where the majority of patients responding to geﬁtinib carry a mutation of the EGFR-TK domain associated with increased sensitivity to geﬁtinib. Since EGFR mutations breast cancer, the 250 mg to be active. This
The Influence of Delivery and Employee Professionalism on Equity Satisfaction in Batak Indigenous People in Medan City

The purpose of this study was to analyze the effect of delivery and employee professionalism on equity satisfaction in the indigenous Batak community in Medan. To conduct the study quantitative research approach have been employed. The population in this study is the Batak ethnic community. Sampling technique was used the Slovin formula with a 5% of error rate, which has produced 200 samples of the community. Determination of the sample used were the Accidental Sampling technique. Data were collected using questionnaires that had distributed to respondents with measurements using a Likert scale. The analysis of the data is based on simple regression analysis and multiple regression. The Findings are discussed in terms of three themes: 1) the delivery variable had an effect on equity satisfaction, 2) the professionalism variable had an effect on equity satisfaction, 3) the delivery variable and professionalism simultaneously had an effect on equity satisfaction.
The Configuration of the Magnetosphere

Brief survey of current notions on the magnetosphere, such as they result from the just completed first decade of in situ magnetospheric exploration. A discussion of the open versus the closed magnetosphere hypotheses and, in particular, of flux transport and substorm phase growth is followed by consideration of a model for the expansion phase of substorms and a review of the requirements for further progress.
Analysis of Behaviour of E-learning Users by Unified Teory of Acceptance and Use of Technology (UTAUT) Model A Case Study of Vocational Education in Halu Oleo University

E-learning (EL) as a supporting tool in learning process has increasingly developed because the implementation of the tool will be helpful for both lecturers and students to be more interactive in delivering materials and to evaluate learning outcomes. Analysis of the user’s behavior was required to measure the success rate of the implementation of e-learning. One of the models used in the present study was Unified Theory of Acceptance and Use of Technology (UTAUT). The model was designed to explain the behavior of the users on the information technology. The main variable was behavioral intention with four elements namely performance expectancy, effort expectancy, social influence and facilitating conditions. Data were collected randomly from the students of vocational education, university of Halu Oleo by distributing questioners to the e-learner users. The data were then validated and analyzed using regression analysis. The results showed EL affected the behavioral intention, performance expectancy, effort expectancy, social influence and facilitating conditions.
Clinical Study Clinical Beneﬁt of Second-Line Palliative Chemotherapy in Advanced Soft-Tissue Sarcoma

Background . This paper aimed to assess the utility of second-line chemotherapy in patients with advanced soft-tissue sarcoma. Materials and Methods . A retrospective search of a prospectively maintained database identiﬁed patients treated between 1991 and 2005. Patients with gastrointestinal stromal tumours, small round cell tumours, and Ewing’s sarcoma were excluded. Response was assessed using WHO and RECIST. Patients who achieved stable disease for 6 months or more were classiﬁed as having disease control. Results . Three hundred and seventy-nine patients received second-line chemotherapy. Eighty-six (22.7%) achieved disease control. Median duration of response was 11 months (95% CI: 9–13). On multivariate analysis, pathological subtype, absence of lung metastases, and the use of combination chemotherapy were independent predictors of disease control. Twenty-eight (16.1%) patients who failed to respond to ﬁrst-line therapy achieved disease control. Eight (2.1%) patients had su ﬃ cient downstaging to enable complete surgical resection. Progression-free survival was 23% at 6 months. Median overall survival was 8 months (95% CI: 7–10 months). On multivariate analysis, synovial histology and absence of lung metastases were associated with improved survival. Conclusion . Second-line chemotherapy can provide clinical beneﬁt in over 20% of soft-tissue sarcoma patients.
Quiescence and Self-Renewal Hematopoietic Stem Cell Status between The Endothelial Antigen ESAM Monitors

Whereas most hematopoietic stem cells (HSC) are quiescent in homeostasis, they actively proliferate in response to bone marrow (BM) injury. Signals from the BM microenvironment are thought to promote entry of HSC into the cell cycle. However, it has been cumbersome to assess cycle status of viable HSC and thus explore unique features associated with division. In this study, we show that expression of endothelial cell-selective adhesion molecule (ESAM) can be a powerful indicator of HSC activation. ESAM levels clearly mirrored the shift of HSC between quiescence and activation, and it was prominent in comparison with other HSC-related Ags. ESAM hi HSC were actively dividing, but had surprisingly high long-term reconstituting capacity. Immunohistochemical analyses showed that most ESAM hi HSC were located near vascular endothelium in the BM after 5-ﬂuorouracil treatment. To determine the importance of ESAM in the process of BM recovery, ESAM knockout mice were treated with 5-ﬂuorouracil and their hematopoietic reconstruction was examined. The ESAM deﬁciency caused severe and prolonged BM suppression, suggesting that ESAM is functionally indispensable for HSC to re-establish homeostatic hematopoiesis. With respect to intracellular regulators, NF- k B and topoisomerase II levels correlated with the ESAM upregulation. Thus, our data demonstrate that the intensity of ESAM expression is useful to trace activated HSC and to understand molecular events involved in stem cell states. The Journal of Immunology , 2012, 189: 000–000.