Miracle-dz/UniFAR-FTUs huggingface dataset:
Ion heat transport dynamics during edge localized mode cycles at ASDEX Upgrade

The edge ion heat transport is analyzed in ASDEX Upgrade (AUG) by combining a comprehensive set of pedestal measurements with both interpretive and predictive modelling. The experimentally determined ion heat diffusivities, χi, are compared with neoclassical theory and the impact of edge localized modes (ELMs) on the edge ion heat transport level is studied in detail. Pedestal matching experiments in deuterium and hydrogen plasmas show that the inter-ELM pedestal χi remains close to the neoclassical value. The additional power needed in hydrogen to get similar pedestal temperatures as in deuterium plasmas mostly affects the electron heat channel, i.e. the electron heat diffusivity increases while the ion heat diffusivity stays at the same level within the uncertainties. Sub-ms measurements of the edge ion temperature allows us to extend the analysis to the entire ELM cycle. During the ELM crash, the ion heat transport is increased by an order of magnitude. The perturbed heat flux increases first at the separatrix, i.e. first the separatrix ion temperature increases, leading to a flatter ion temperature gradient, followed by a decrease of the whole pedestal profile. The ion heat transport returns to its pre-ELM neoclassical level 3–4 ms after the ELM crash.
Social Identity Negotiation in Online Communication: Understanding the Formation of Violent Normalization as Means to Deal with Violent Crimes in Online Facebook Group ‘Info Cegatan Jogja’

In the last decade, street violence in the Special Region of Yogyakarta (DIY) has increased immensely. Whether intentional or organized, violence has become news, increasingly appearing on various media and social platforms. This phenomenon contradicts the predicate of Yogyakarta as a city of students and a city of culture. Through such background, this study encourages investigating the socio-cultural contexts of such increasing violence in a city, promoting its branding as a non-violence city. This study analyses one of the largest online social platforms in Yogyakarta, called ‘Info Cegatan Jogja’ (ICJ). Applying an ethnographic approach, quantitative and qualitative data were collected and analyzed using the sentiment analysis method. The study finds that the high rate of violence is not solely the result of street violence itself, but is also supported by the act of justifying violence with the general idea that the accurate way to deal with violence is through violence. In other words, society begins to assume that if it is treated as a curative measure, then violence is accepted as something to be normalized. Keywords: Violence, Info Cegatan Jogja, social media, negotiation, violent normalization.
Neural Stem Cell-Derived Exosomes Improve Neurological Function in Rats with Cerebral Ischemia-Reperfusion Injury by Regulating Microglia-Mediated Inflammatory Response

Purpose To investigate the effect of neural stem cell-derived exosomes (NSC-Exos) on neural function after rat cerebral ischemia-reperfusion injury by regulating microglia-mediated inflammatory response. Methods SD rats were randomly divided into Sham group, IRI group, PBS group and NSC-Exos group. Each group was divided into 1d, 3d, 7d and 14d subgroups. In the Sham group, only cervical vessels were isolated without blockage. MCAO model was constructed in the other three groups by blocking middle cerebral artery with thread embolism. PBS group and NSC-Exos group were, respectively, injected into the lateral ventricle of PBS and Exos. Neurobehavioral deficit scores were performed for each subgroup at relative time points, then brains were taken for TTC staining, parietal cortex histopathology and microglia-mediated inflammatory response-related factors were detected. Results Compared with Sham group, neurological defect score and infarction volume in both the IRI and PBS groups were significantly increased. The exploration target quadrant time and escape latency time of maze test were increased. The number of CD86+/Iba1+ double-positive cells increased, while CD206+/Iba1+ double-positive cells decreased. The expressions of IL-6 and CD86 in parietal cortex were increased, while the expressions of Arg1 and CD206 were decreased. Compared with the IRI group and PBS group, neurological defect score and infarction volume in NSC-Exos group were decreased. The exploration target quadrant time and escape latency time of water maze test were decreased. The number of CD206+/Iba1+ double-positive cells increased, while CD86+/Iba1+ double-positive cells decreased. The expressions of Arg1 and CD206 in parietal cortex were increased, while the expressions of IL-6 and CD86 were decreased. Conclusion NSC-Exos can promote the polarization of microglia, that is, inhibit the polarization of M1 and promote polarization of M2, reduce microglia-mediated neuroinflammation, suggesting that NSC-Exos may be a strategy for the treatment of microglia-mediated neuroinflammation after ischemic brain injury.
Preparation of a probiotic quinoa beverage by enzymatic hydrolysis of its starches and subsequent lactic acid fermentation

BACKGROUND: The concern about consuming healthy foods has increased in recent years. Not only are they expected to comply with essential feeding functions, but they also provide health benefits. Probiotics are one of the main functional components expected to be present in functional foods and beverages. They provide many health benefits and stand out due to their metabolic capacities and adaptability to different habitats. In addition, Quinoa seeds contain valuable quantities of quality protein and nutritional values of carbohydrates, proteins, fats, fibers, and mineral substances for which they are considered an ideal dietary alternative.OBJECTIVES: This research aimed to elaborate on a probiotic quinoa beverage, which combines the effect of enzymatic hydrolysis of the starches obtained from its seeds with lactic acid fermentation using probiotic cultures, seeking to enhance its nutritional properties and converting it into a functional beverage.METHODS: For this, fermentations were carried out in three different concentrations of probiotic cultures (inoculum): 10%, 5%, 1%, and three other different fermentation times: 8, 10, and 12 hours. pH, Total titrable acidity expressed as lactic acid (%), reducing sugars, and soluble solids were measured. After that, the beverage was formulated with honey, carob, preservatives, and mango flavoring. RESULTS: Statistical analysis indicated optimal conditions were achieved with 10% probiotic cultures and 10 hours of fermentation. The microbiological analysis confirmed the presence of probiotic microorganisms at a concentration of 108 CFU/mL. Proximal analysis indicated that the composition contained 84.6 Kcal, 19.3 g of carbohydrates, and 1.4 g of protein per 100 g of beverage. CONCLUSIONS: The probiotic quinoa beverage was produced and can be considered in the group of plant-based foods, as well as a functional beverage, since the probiotic cultures it contains contribute to maintaining the intestinal microbiota and prevent the onset of chronic diseases.
Influence of preparedness on caregiver burden, depression, and quality of life in caregivers of people with disabilities

Introduction Caregiver preparedness is defined as the perceived preparation of caregivers to care for the physical and emotional needs of the patient. Purpose This study investigated caregiver preparedness and its influences on caregiver burden, depression, and quality of life (QoL) in caregivers of individuals with disabilities. Methods We conducted a multicenter cross-sectional survey study on caregivers caring for patients with disabilities. Sociodemographic characteristics were collected via questionnaires. The Preparedness for Caregiving Scale (PCS), Burden Interview (BI), Center for Epidemiologic Studies Depression Scale (CES-D), and EuroQol-Visual Analogue Scale (EQ-VAS) were administered. Results A total of 151 caregivers were enrolled. The mean age of caregivers was 53.7 ± 12.4 years, and 80.8% were female. The majority of participants were the main caregivers of patients with stroke, spinal cord injury, or traumatic brain injury. The mean PCS score was 2.1 ± 0.9, demonstrating significant relationships with BI (r = −0.512, p < 0.001), CES-D (r = −0.622, p < 0.001), and EQ-VAS (r = 0.441, p < 0.001). The CES-D was significantly associated with the PCS after controlling other variables. However, PCS did not show any correlation with the duration of caregiving or amount of time spent per day on caregiving. Discussion The clinical implications of this study are that higher caregiver preparedness is a predictor of less caregiver burden and depression, and better QoL. However, preparedness did not increase as the duration or time spent on caregiving was extended. Therefore, efforts to enhance the caregivers’ preparedness are required to reduce caregiver burden and improve health outcomes for both caregivers and patients.
AUTOMATED ULCER AND BLEEDING CLASSIFICATION FROM WCE IMAGES USING MULTIPLE FEATURES FUSION AND SELECTION

In the area of medical imaging and computer vision, automatic diagnosis of ulcer and bleeding from wireless capsule endoscopy images has been an active research domain. It contains several challenges including low contrast, complex background, lesion shape and color which affect its segmentation and classification accuracy. In this article, a novel method for automated detection and classification of stomach infection is implemented. The proposed method consists of four major steps including preprocessing, lesion segmentation, image representation and classification. The lesion contrast is improved in preprocessing step by employing 3D-box filtering, 3D-median filtering and HSV transformation. In the second step, geometric features are extracted and applied to the saturated channel to give a binary image. The binary image is further improved by fusion of generated mask. After that, extraction of three types of features including color, shape and surf is performed from HSV and binary segmented images and their information is fused by a serial based method. A principal component analysis (PCA) and correlation coefficient based feature selection approach is proposed which are classified by multi class support vector machine (M-SVM). The proposed method is evaluated on personally collected images of three different classes including ulcer, bleeding and healthy. The M-SVM performs well with a maximum accuracy of 98.3% which shows the authenticity of presented method.
A Review of Paleo El Niño-Southern Oscillation

The Earth has seen El Nino-Southern Oscillation (ENSO)—the leading mode of interannual climate variability—for at least millennia and likely over millions of years. This paper reviews previous studies from perspectives of both paleoclimate proxy data (from traditional sediment records to the latest high-resolution oxygen isotope records) and model simulations (including earlier intermediate models to the latest isotope-enabled coupled models). It summarizes current understanding of ENSO’s past evolution during both interglacial and glacial periods and its response to external climatic forcings such as volcanic, orbital, ice-sheet and greenhouse gas forcings. Due to the intrinsic irregularity of ENSO and its complicated relationship with other climate phenomena, reconstructions and model simulations of ENSO variability are subject to inherent difficulties in interpretations and biases. Resolving these challenges through new data syntheses, new statistical methods, more complex climate model simulations as well as direct model-data comparisons can potentially better constrain uncertainty regarding ENSO’s response to future global warming.
Evaluation of Parents’ Knowledge about Nutritional Management of children with Phenylketonuria

Abstract Objective(s): to Evaluation of Parents’ Knowledge about Nutritional Management of kids with Phenylketonuria; to Identify the association between parents’ Knowledge about nutritional management then their demographic variables of fathers, mothers (parents age, residence then socioeconomic position). Methodology: A non-experimental project; was accompanied on parents of phenylketonuria kid in Baghdad town since the period 3 June to 5 October 2022. A Non-probability sample (convenience) of 35 PKU children and their parents (father and mother) was selected Purposively from the hospitals that are select for the study. A survey is built for the purpose of the education throughout a review of applicable literature. It composed of two parts: The first part Demographic Characteristics: parents' Demographic features and Socioeconomic Status; And the second part is Parents’ Knowledge about Nutritional Management of children with Phenylketonuria. The internal consistency between items was strongminded by using alpha Cronbach`s coefficient. The consistency analysis shows very good evaluation for knowledge scale. Data was collected from one hospital in Baghdad city beside al-Rusafa\ Ibn Al-Baladi Hospital for maternity and Children, after the approval of the director of the hospital and the acceptance of parents to involve themselves and their children in the study. data are examined using Statistical Data Analysis: Frequencies, percentage, mean scores, standard deviation, mean, whole scores then ranges-test and one - way analysis of variance. Results: Outcomes presented that (62.9%) of the parents showing moderates knowledge of Parents about and nutrition knowledge of children with phenylketonuria during pre-test time, while they show very good close of knowledge through the post-examination time 1 and post-examination time 2. Conclusions: Overall evaluation of Parents’ knowledge about Nutritional Management for Children with Phenylketonuria showing moderate knowledge about nutritional management during pre-test time, their knowledge level is increased to very good through the post-examination time 1 and 2, and a study confirms that older parents are better knowledge. Recommendations: The study recommends that Parents of phenylketonuria children should be very well-oriented and greatly aware about the importance of Nutritional Management. Additional research studies container remains carried out with respect to big sample scope and wide variety variables, particularly, nationwide studies. Key Words: Evaluation, Parents’ Knowledge, Nutritional Management, Phenylketonuria.
Evaluation of electrocardiographic parameters in amputee football players

Objective The present study aimed to compare electrocardiographic (ECG) parameters of amputee football players (AF) with football players without disability (FP) and sedentary individuals without disability (SI). Methods A total of 32 participants (AF = 9, FP = 11, SI = 12) were included in the study. ECG parameters including P-wave amplitude, P-wave duration, PR interval, QRS duration, RR interval, QT interval, corrected-QT interval (QTc), ST segment duration, Tp-e duration, Tp-e/QT and Tp-e/QTc ratios were assessed in all the study participants by using a 12-lead ECG device. OneWay ANOVA Test was used for statistical analysis. Results Of all ECG parameters, P-wave amplitude and QTc were significantly higher in the AF group in comparison to FP and SI groups. QRS duration was found to be lower in the AF group when compared to FP and SI groups. Myocardial repolarization parameters including Tp-e duration, Tp-e/QT and Tp-e/QTc ratios were similar between groups, as were other parameters such as P-wave duration, PR interval, RR interval, QRS duration and QT interval. Conclusion It was found that some ECG parameters of amputee football players differ from those with non-disabled players and non-disabled sedentary individuals. These different parameters were within normal limits.
TURBULENT EFFECTS OF LIQUID METAL FLOW UNDER STRONG FRINGING MAGNETIC FIELDS

This paper presents direct numerical simulations of a liquid metal flow under a space-varying magnetic field in an insulating circular duct. This is a generalization of a magnetohydrodynamic (MHD hereafter) benchmark case (MHD benchmark, 2005) in the nuclear fusion field. The benchmark was proposed after the experiments of Reed et al. (1987) owing to its similarity to the typical parameters appearing in liquid metal blankets of nuclear fusion reactors (Molokov and Reed, 2003). The main task at hand is to accurately define the transitional effects (suppression, triggering, intermittency) related to fringing magnetic fields and turbulence. For that purpose, the present paper addresses two qualitatively different cases: the first one considers the case of a turbulent flow (Reb = 7972, Reτ ≈ 520) entering a strong magnetic field (case MHD1) while the later considers the MHD flow leaving a strong magnetic field (case MHD 2). For brevity, this paper presents only some illustrative results concerning different Ha numbers for the case MHD1 and one very strong magnetic field (Ha = 7000) for the case MHD2. Additionally, preliminary purely hydrodynamic computations are presented (case HD, at an identical flow regime with the MHD cases). An excellent agreement has been obtained against both previous experimental (Durst et al., 1995) and numerical results (Wagner et al., 2001).
Catalase Gene Family in Durum Wheat: Genome-Wide Analysis and Expression Profiling in Response to Multiple Abiotic Stress Conditions

Catalase (CAT) is an antioxidant enzyme expressed by the CAT gene family and exists in almost all aerobic organisms. In fact, the CAT enzyme modulates the hydrogen peroxide (H2O2) contents in cells by translating this toxic compound into water (H2O) and O2− to reduce reactive oxygen species (ROS) contents in cells. ROS are produced as a result of biotic and abiotic environmental stressors. To avoid ROS toxicity, plants are armed with different enzymatic and non-enzymatic systems to decompose ROS. Among the enzymatic system, CAT proteins are well studied. CAT not only controls growth and development in plants but is also involved in plant defense against different stresses. So far, the CAT gene family has not been reported in durum wheat (Triticum turgidum ssp. durum L.). Therefore, a genome-wide comprehensive analysis was conducted to classify the CAT genes in the durum wheat genome. Here, six TdCAT genes were identified. Based on phylogenetics, the TdCAT genes belong to three groups (Groups I–III) which is explainable by their comparable structural characteristics. Using bio-informatic analysis, we found that the secondary and tertiary structures were conserved among plants and present similar structures among durum wheat CATs. Two conserved domains (pfam00199 and pfam06628) are also present in all identified proteins, which have different subcellular localizations: peroxisome and mitochondrion. By analyzing their promoters, different cis-elements were identified, such as hormone-correlated response and stress-related responsive elements. Finally, we studied the expression pattern of two catalase genes belonging to two different sub-classes under different abiotic stresses. Expression profiling revealed that TdCAT2 and TdCAT3 presented a constitutive expression pattern. Moreover, both genes are induced in response to salt, mannitol, cold, heat and ABA. Thus, we speculate that those genes are activated by different stresses, such as oxygen deficiency, light, cold, abscisic acid and methyl jasmonate. Further, this study will help in understanding the behavior of CAT genes during environmental stress in durum wheat and in Triticeae species in general.
The results of Muller Muscle Conjunctival Resection versus Levator Advancement for mild to moderate ptosis

Purpose: To compare the surgical outcomes of Muller muscle conjunctival resection (MMCR) and levator advancement (LA) in patients with mild to moderate blepharoptosis. Methods: A retrospective review of patients who underwent surgery for mild to moderate ptosis between 2015 and 2020 was performed. The degree of ptosis was graded based on the amount of upper eyelid drooping: mild ≤ 2 mm and moderate < 4 mm. Surgical success was defined as post-operative marginal reflex distance 1 (MRD1) ≥ 4.0 and ≤ 5.0 mm, and a satisfactory eyelid contour. Results: A total of 82 eyes of 65 patients underwent ptosis repair surgeries. MMCR was performed in 48 eyes and LA in 34 eyes. Under-correction was detected in 8.3% and 11.8% of the patients in MMCR group and LA group respectively. There was no patient with over-correction in the MMCR group postoperatively, 3 patients in the LA group had over-correction (0% vs. 8.8% respectively). The success rate in our study was found to be 91.7% in the MMCR group and 72.2% in the LA group. Conclusions: The MMCR and LA procedures are effective approaches in treating patients with mild to moderate eyelid ptosis in our population. Each procedure had its superiority in selected groups of patients. However, the complication rate and duration of surgery were found to be lower in MMCR group. Abbreviations: LA = Levator Advancement, LF = Levator Function, MMCR = Muller Muscle Conjunctival Resection, MRD 1 = Marginal Reflex Distance
New Crystal Form of Human Neuropilin-1 b1 Fragment with Six Electrostatic Mutations Complexed with KDKPPR Peptide Ligand

Neuropilin 1 (NRP1), a cell-surface co-receptor of a number of growth factors and other signaling molecules, has long been the focus of attention due to its association with the development and the progression of several types of cancer. For example, the KDKPPR peptide has recently been combined with a photosensitizer and a contrast agent to bind NRP1 for the detection and treatment by photodynamic therapy of glioblastoma, an aggressive brain cancer. The main therapeutic target is a pocket of the fragment b1 of NRP1 (NRP1-b1), in which vascular endothelial growth factors (VEGFs) bind. In the crystal packing of native human NRP1-b1, the VEGF-binding site is obstructed by a crystallographic symmetry neighbor protein, which prevents the binding of ligands. Six charged amino acids located at the protein surface were mutated to allow the protein to form a new crystal packing. The structure of the mutated fragment b1 complexed with the KDKPPR peptide was determined by X-ray crystallography. The variant crystallized in a new crystal form with the VEGF-binding cleft exposed to the solvent and, as expected, filled by the C-terminal moiety of the peptide. The atomic interactions were analyzed using new approaches based on a multipolar electron density model. Among other things, these methods indicated the role played by Asp320 and Glu348 in the electrostatic steering of the ligand in its binding site. Molecular dynamics simulations were carried out to further analyze the peptide binding and motion of the wild-type and mutant proteins. The simulations revealed that specific loops interacting with the peptide exhibited mobility in both the unbound and bound forms.