Miracle-dz/UniFAR-FTUs huggingface dataset:
Long-term Preservation of Left Ventricular Function and Heart Failure Incidence with Ablate and Pace Therapy Utilizing Biventricular Pacing

Ablate and pace therapy has been utilized to improve symptoms in patients with symptomatic atrial fibrillation (AF) but requires dedicated ventricular pacing. Biventricular (BiV) pacing may eliminate the potential negative consequences of dedicated right ventricular (RV) pacing. We reviewed 245 patients who were considered at risk for congestive heart failure (CHF) with preserved left ventricular ejection fraction (LVEF) and underwent ablate and pace therapy with a BiV pacemaker. A total of 225 patients had follow-up greater than 1 year, and 175 patients had echocardiogram data prior to the procedure. Follow-up echocardiograms were obtained. Patients were assessed whether they were predominantly in sinus rhythm (SR) or AF. Patients were screened for CHF admissions during the follow-up period. All 245 patients had successful implantation without significant complications. The mean follow-up was 37i18 months. LVEF remained preserved over the follow-up period (53i12% pre-ablation and 58i11% post ablation). Patients in SR showed a significant improvement in LVEF, whereas the mild improvement in patients in AF did not reach statistical significance. The 1-year survival rate of the total population at 1, 3, and 5 years is 97.4%, 87.6%, and 78.0%, respectively. The CHF hospitalization-free rates at 1, 3, and 5 years are 100%, 96.8%, and 92.7%, respectively. Ablate and pace therapy with BiV pacing results in long-term preservation in LVEF with a low incidence of heart failure in patients with preserved left ventricular function at risk for heart failure. A large-scale randomized clinical trial is warranted to determine if this approach should be widely utilized.
(E)-4-{2-[(4-Chlorophenyl)iminomethyl]phenoxy}phthalonitrile

In the title compound, C21H12ClN3O, the phenoxy ring makes dihedral angles of 51.42 (5) and 65.01 (6)°, respectively, with the chlorophenyl and phthalonitrile rings. In the crystal structure, the molecules are interlinked through weak C—H⋯N and C—H⋯π contacts, and π–π stacking interactions via crystallographic inversion centres form a three-dimensional network. The distance between the centroids of the phthalonitrile rings is 3.9104 (11)Å, with a slippage between the rings of 1.626 Å and a perpendicular distance between the rings of 3.556 Å.
A Prospective Randomized Study Comparing Open Versus Laparoscopy-Assisted Distal Gastrectomy in Early Gastric Cancer

Background: We conducted a prospective randomized trial to compare laparoscopy-assisted distal gastrectomy (LADG) including lymphadenectomy with open distal gastrectomy for the management of early gastric cancer (EGC). Methods: Forty-seven patients who had been diagnosed endoscopically with EGC were included in a study that ran from November 2001 to August 2003. With the aid of random number table, 23 patients were assigned to the open group (group O) and 24 patients were assigned to the LADG group (group L). Results: Estimated blood loss and transfusion amounts were similar in the two groups. The mean postoperative hospital stay and the duration of analgesic administration were shorter for group L but not significantly so. The mean number of harvested lymph nodes was 38.1 in the O group and 31.8 in the L group (p = 0.098). Postoperative pulmonary complications occurred more frequently in the O group (p = 0.043). At a median follow-up of 14 months, there has been no recurrence of disease in either group. Conclusion: In terms of resulting in fewer pulmonary complications while maintaining the curability of EGC, LADG has a clear advantage over its open counterpart.
Family support within a child care centre: A case study

This review explored the effects of stress in the family environment and the role that family support plays in reducing this stress. Specifically, research concerning the role that child care workers play in providing suppott to families who utilise their services was examined. The literature showed that there are many stressors facing families today and that the experience of stress in the family environment can have a detrimental effect on children's developmental outcomes. While the literature showed that experiencing social support can reduce stress in the family environment, it was also found that many families face isolation from such forms of support. Family suppott delivered through existing services such as child care centres has been shown to help these families who are stressed and isolated from social suppotts. However, there is little research that examines the role that childcare workers play in providing support to families. Therefore, more research is needed to examine the role that child care workers play in providing suppott to families and the key interactions between workers and families that can generate this suppott.
Increasing Number and Disproportionate Morbidity and Mortality Associated with Multistate Foodborne Disease Outbreaks — United States, 1973-2010

Results: From 1973–2010, multistate foodborne disease outbreaks accounted for 234 (0.8%) of 27,989 total outbreaks and resulted in 3% of all outbreak-associated illnesses, 10% of hospitalizations, and 16% of deaths. The number of multistate outbreaks increased from an average of 3.4/year during the first five years of the surveillance period to 16.8/year in the most recent five years. Most multistate outbreaks were caused by Salmonella (49%) and Shiga toxin-producing E. coli (STEC, 26%). Among 96 Salmonella outbreaks with a food reported, most were attributed to fruits/nuts (24%), vine or stalk vegetables (20%), and sprouts (17%). Among 57 STEC outbreaks, most were attributed to beef (56%) and leafy green vegetables (23%). Conclusions: From 1973–2010, reported multistate outbreaks accounted for an increasing number of foodborne disease outbreaks and contributed a disproportionate share of outbreak-associated morbidity and mortality. Knowing the implicated foods and pathogens can help to identify important sources of contamination and inform the interventions of regulatory agencies and industry to improve the safety of our food supply.
Insulin pathway and its correlation with ageing and longevity

OF PAPERS PRODUCED DURING PhD COURSE AND RELEVANT TO THIS THESIS 1. Accardi G, Caruso C, Colonna-Romano G, Camarda C, Monastero R, Candore G. Can Alzheimer disease be a form of type 3 diabetes? Rejuvenation Res. 2012;15:217-21. Abstract Alzheimer disease (AD) and metabolic syndrome are two highly prevalent pathological conditions of Western society due to incorrect diet, lifestyle, and vascular risk factors. Recent data have suggested metabolic syndrome as an independent risk factor for AD and pre-AD syndrome. Furthermore, biological plausibility for this relationship has been framed within the "metabolic cognitive syndrome" concept. Due to the increasing ageing of populations, prevalence of AD in Western industrialized countries will rise in the near future. Thus, new knowledge in the area of molecular biology and epigenetics will probably help to make an early molecular diagnosis of dementia. An association between metabolic syndrome and specific single-nucleotide polymorphisms (SNPs) in the gene INPPL1, encoding for SHIP2, a SH2 domain-containing inositol 5-phosphatase involved in insulin signaling, has been described. According to recent data suggesting that Type 2 diabetes represents an independent risk factor for AD and preAD, preliminary results of a case-control study performed to test the putative association between three SNPs in the SHIP2 gene and AD show a trend toward association of these SNPs with AD.
OVERUSE OF ANTIBIOTICS FOR ASYMPTOMATIC BACTERIURIA IN A UNIVERSITY TEACHING HOSPITAL

Public Health Significance: Antibiotic resistance is an increasingly important public health issue. Antibiotic resistance emerges from antibiotic use, and unnecessary and incorrect usage of these drugs is accelerating the increasing prevalence and severity of resistant organisms. Misdiagnosis of a urinary tract infection is one of the main causes of unnecessary antibiotic use. Problem Statement: Antibiotic overuse can lead to adverse patient outcomes, and antibiotics should be used judiciously and according to published treatment guidelines. Many clinicians at healthcare facilities do not adhere to treatment guidelines for asymptomatic bacteriuria; often clinicians incorrectly give asymptomatic patients a diagnosis of a urinary tract infection which has been shown to yield high rates of unnecessary antibiotic use. Objective: To determine whether the University Teaching Hospital adheres to IDSA treatment guidelines for UTI and ABU for this cohort of patients and explore the relationship between failure to adhere to IDSA guidelines of treatment of ABU and excess pharmaceutical costs. Setting: A public acute care teaching hospital affiliated with a local state university in central Texas. Participants: Patients included in the cohort were at least 18 years of age and admitted to the hospital for >2 days between the dates of September 2011 and February 2012 and diagnosed with a UTI. Main outcome measures: Frequency of patients who were incorrectly diagnosed with a UTI who were asymptomatic and treated inappropriately, total number of antibiotics used for these patients, and the costs of these unnecessary antibiotics. Results: Of the 88 included patients, 26 patients (29.5%) had no documentation of any symptoms of a UTI but were diagnosed and treated inappropriately. There were a total of 353 doses given to these patients for a total excess cost of $512.45. Eleven patients (12.5%) were classified as a “questionable” diagnosis of a UTI because documentation was not clear enough to indicate if the patient had a UTI or ABU. There were a total of 234 doses given to these patients for a total excess cost of $271.76. Conclusion: Based upon this sample, clinicians in this facility do not strictly adhere to IDSA treatment guidelines. The clinicians could benefit from an antibiotic stewardship program or an educational intervention to improve adherence to the current IDSA guidelines.
Research Article A school based survey on hygiene in an urban area of North India.

Sanitation is one of the basic determinants of quality of life and human development index. Good sanitary practices go a long way in helping to prevent diseases. Hand washing and oral hygiene are the basic steps to maintaining good health. The present study was a school based survey undertaken among children in a government school in an urban area of north India with the objectives of finding out the prevalent status of personal hygiene in the study population. The total sample was 684 students. The survey was conducted using the GSHS Core Questionnaire Hygiene Module of the Global School-Based Student Health Survey (GSHS) 2013 Core Questionnaire Modules. There were three classes - class I, II and III, each having five sections and a total of 246, 220 and 218 children respectively (N=684). Most of the junior children carried their own water bottles to the school, while this practice decreased as they grew older and senior. Almost all the children adhered to the good habit of washing their hands after using the toilet or latrine, always, or at least most of the times, but the practice of using soap was variable. The present study revealed a generally good standard of hygiene amongst the study population. However, steps are required to be taken to improve the status of personal hygiene of all the school children, who are found lacking in this aspect, through various coordinated primordial as well as primary preventive measures like imparting health education.
Effects of Walking and Physical Activity on Glucose Regulation among Type 2 Diabetics

Background: Physical activity, especially walking is strongly recommended to control blood glucose among type 2 diabetic patients. Furthermore, physical activity is one of the most important tools to prevent secondary diabetes complications among type 2 diabetic patients such as retinopathy, nephropathy, neuropathy etc. The purpose of the study was to examine the association between the level of walking and physical activity and glucose control among Korean adults with type 2 diabetes. Methods: A total of 250 patients with type 2 diabetes (98 males and 152 females) were recruited (mean age = 62.1 ± 10.2 years) in the current study. The height, weight, waist and hip circumference were measured, and the level of physical activity and total walking hour were measured by physical activity scale for elderly (PASE). High density lipoprotein cholesterol (HDL-C), total cholesterol, triglyceride, fasting glucose and oral glucose tolerance test, creatinine, uric acid, total protein, albumin, hemoglobin A1c were measured. Results: After adjusting for potential covariates such as age, education, occupation income, smoking, and drinking, male patients who spent least time in walking were more likely to have 2 hour serum glucose level in oral glucose tolerance above 200 mg/dL than counterparts who spent most time in walking with age adjusted (Relative Risk (RR) = 11.75, 95% Confidence Interval (CI) = 1.94-71.00). Male patients who were in the least active group were 5.92 time (95% CI = 1.39-25.28) more likely to have 2 hour serum glucose level in oral glucose tolerance over 200 mg/dL than counterparts in the most active group. However, there was no significant finding in females. Conclusions: The current study showed that physical activity and walking are effective method to maintain glucose tolerance among type 2 diabetic male patients. (KOREAN DIABETES J 32:60~67, 2008)
2-[4-(Benzyloxy)benzylidene]malononitrile

In the title molecule, C17H12N2O, the dihedral angle between the two benzene rings is 84.98 (10)°. The dicyanoethylene group is coplanar with the benzene ring to which it is bonded. No classic hydrogen bonds were found in the crystal.
(E)-2-[1-(3-Amino-4-chlorophenylimino)ethyl]-4-bromophenol

The title Schiff base compound, C14H12BrClN2O, exists in an E configuration with respect to the central C=N double bond. The amino group adopts a pyramidal configuration. The dihedral angle between the two benzene rings is 76.88 (10)° and an intramolecular O—H⋯N hydrogen bond forms a six-membered ring, generating an S(6) ring motif. In the crystal structure, molecules are linked into chains along [010] via N—H⋯O hydrogen bonds. The presence of π–π interactions [centroid–centroid distance = 3.6244 (12) Å] further stabilizes the crystal structure.
Role of Membrane Transporters in Drug Delivery, Drug Disposition And Drug-Drug Interactions

Tissues such as liver, kidney, brain and intestine expresses membrane transporters which play a vital role in drug absorption, distribution, metabolism and excretion. Understanding of functionality and molecular expression of drug transporters can prove to be of utmost importance in drug delivery or drug design by targeting specific transporter proteins. It’s a well-known fact that drug transporters play an important role in governing drug disposition which act as potential piece of information during the drug discovery and development process. By exploring the transporter functionality chances of delivering a therapeutic agent to the target organ enhances. Transporter targeted drug delivery helps in improving the bioavailability, controlling the elimination process and also avoid distribution to non-specific organs, hence diminishes the odds of toxic adverse effects. It is always suitable to choose a potential molecule which may or may not interact with the membrane transporters, depending on whether such an interaction is of any use or not. Activity of individual transport process can be examined by exploring the expression system of transporters. Therapeutic efficacy many important drugs, directly or indirectly, get affected due to genetic polymorphisms and drug-drug interactions involving membrane transporters which ultimately effects the pharmacokinetics of a drug molecule. During the drug discovery and development process, knowledge about the contribution of these transporters
1-(2,6-Diisopropylphenyl)-1H-benzimidazole

In the title compound, C19H22N2, both the benzimidazole unit and the 2,6-diisopropylphenyl group are essentially planar [maximum deviations from the least-squares planes of 0.005 (1) and 0.009 (1) Å, respectively]. The dihedral angle between the two planes is 79.6 (7)°. In the crystal, molecules are linked into chains along the a-axis direction by weak C—H⋯N interactions. The crystal structure also features C—H⋯π interactions, which link the chains into a three-dimensional network.
Seroprevalence of Leptospirosis in Clinically Ailing Bovine

The purpose of this study was to carried out seroepidemiological study of leptospirosis in clinically ailing cattle and buffaloes of South Gujarat where cases of leptospirosis in human is increase every monsoon since last decade. To determine clinical pattern of bovine Leptospirosis in this area a total of 130 serum samples of cattle and buffaloes were collected randomly from different age groups of cattle and buffaloes of either sex reared in this area and tested by microscopic agglutination test (MAT) using different serovars of Leptospira spp. The prevalence of leptospiral antibodies was detected in 15.84 and 17.24% in clinically ailing cattle and buffaloes, respectively. In clinically ailing seropositive cattle history of mastitis/agalactia/oligolactia was recorded in maximum number of cases (24.00%) followed by abortion (20.00%), fever (14.81%), repeat breeding (11.76%) and anorexia (5.88%) in different combinations. In seropositive clinically ailing buffaloes the clinical signs included mastitis (30.00%), fever (16.66%) and abortion (14.28%). In clinically ailing cattle highest prevalence was noted in animals above 4 years of age (20.00%) followed by 1–4 years of age (4.76%) whereas in clinically ailing buffalo seropositivity was recorded only in above 4 years of age (20.00%). The most prevalent serovar pomona has been reported from different clinical conditions in both cattle and buffaloes. Based on present and few past investigation reports the sero-epidemiological condition of bovine leptospirosis that need due attention as South Gujarat region is endemic zone for leptospirosis.
Chandra Observations of High-energy X-Ray Sources Discovered by INTEGRAL

The International Gamma-Ray Astrophysics Laboratory (INTEGRAL) satellite has detected in excess of 1000 sources in the ∼20–100 keV band during its surveys of the sky over the past 17 years. We obtained 5 ks observations of 15 unclassified INTEGRAL Gamma-Ray (IGR) sources with the Chandra X-ray Observatory in order to localize them, to identify optical/IR counterparts, to measure their soft X-ray spectra, and to classify them. For 10 of the IGR sources, we detect Chandra sources that are likely (or in some cases certain) to be the counterparts. IGR J18007–4146 and IGR J15038–6021 both have Gaia parallax distances, placing them at and kpc, respectively. We tentatively classify both of them as intermediate polar-type cataclysmic variables. Also, IGR J17508–3219 is likely to be a Galactic source, but it is unclear if it is a Dwarf Nova or another type of transient. For IGR J17118–3155, we provide a Chandra localization, but it is unclear if the source is Galactic or extragalactic. Based on either near-IR/IR colors or the presence of extended near-IR emission, we classify four sources as active galactic nuclei (AGNs; IGR J16181–5407, IGR J16246–4556, IGR J17096–2527, and IGR J19294+1327), and IGR J20310+3835 and IGR J15541–5613 are AGN candidates. In addition, we identified an AGN in the INTEGRAL error circle of IGR J16120–3543 that is a possible counterpart.
Learning Structure-Appearance Joint Embedding for Indoor Scene Image Synthesis

Advanced image synthesis methods can generate photo-realistic images for faces, birds, bedrooms, and more. However, these methods do not explicitly model and preserve essential structural constraints such as junctions, parallel lines, and planar surfaces. In this paper, we study the problem of structured indoor image generation for design applications. We utilize a small-scale dataset that contains both images of various indoor scenes and their corresponding ground-truth wireframe annotations. While existing image synthesis models trained on the dataset are insufficient in preserving structural integrity, we propose a novel model based on a structure-appearance joint embedding learned from both images and wireframes. In our model, structural constraints are explicitly enforced by learning a joint embedding in a shared encoder network that must support the generation of both images and wireframes. We demonstrate the effectiveness of the joint embedding learning scheme on the indoor scene wireframe to image translation task. While wireframes as input contain less semantic information than inputs of other traditional image translation tasks, our model can generate high fidelity indoor scene renderings that match well with input wireframes. Experiments on a wireframe-scene dataset show that our proposed translation model significantly outperforms existing state-of-the-art methods in both visual quality and structural integrity of generated images.
Deep Teams with Risk-Sensitive Linear Quadratic Models: A Gauge Transformation

Motivated from invariance principle and recent developments in artificial intelligence, we introduce a risk-sensitive linear quadratic control system whose solution resembles a deep neural network. In particular, we consider a population of decision makers that are partitioned into multiple sub-populations wherein the decision makers in each sub-population are coupled in both dynamics and cost function through a few linear regressions of the states and actions of the decision makers. Two non-classical information structures are considered: deep-state sharing and partial deep-state sharing, where deep state refers to the linear regression of the states of the decision makers in each sub-population. For deep-state sharing structure, a closed-form representation of the globally optimal strategy is obtained in terms of a deep Riccati equation, whose dimension is independent of the number of decision makers in each sub-population, hence scalable. In addition, two sub-optimal sequential strategies under partial deep-state sharing information structure are proposed by introducing two Kalman filters, one based on the finite-population model and the other one based on the infinite-population model. It is shown that the prices of information associated with the above sub-optimal solutions converge to zero as the number of decision makers goes to infinity. Two numerical examples of a supply-chain management system are presented to demonstrate the efficacy of the obtained results.
Full exact solution of the out-of-equilibrium boundary sine Gordon model.

The massless boundary sine-Gordon (SG) model is the only interacting impurity model with a known exact solution out-of-equilibrium, yet existing so far only for integer values of the sine Gordon coupling $\lambda$ [Phys. Rev. Lett. {\bf74}, 3005 (1995)]. We present here a full exact solution for arbitrary rational values of $\lambda$, at arbitrary voltage $V$ and temperature $T$. We use the "string" solutions of the bulk SG model, here regarded as genuine quasiparticles avoiding charge diffusion in momentum space. We carefully present the finite voltage and temperature thermodynamics of this gas of interacting exotic quasiparticles, whose very nature depends on subtle arithmetic properties of the rational SG parameter $\lambda$, and explicitly check that the string representation is thermodynamically complete. By considering a Loschmidt echo, we derive the exact transmission probability of strings on the impurity. We obtain the exact universal scaling function for the electrical current $I(V,T)$. Our results are in excellent agreement with recent experimental out-of-equilibrium data and question the reality of these exotic quasiparticles.