Miracle-dz/UniFAR-FTUs huggingface dataset:
Cisplatin or Doxorubicin Reduces Cell Viability via the PTPIVA3-JAK2-STAT3 Cascade in Hepatocellular Carcinoma

Introduction Hepatocellular carcinoma (HCC) accounts for 80% of all liver cancers and is the 2nd leading cause of cancer-related death in Taiwan. Various factors, including rapid cell growth, a high recurrence rate and drug resistance, make HCC difficult to cure. Moreover, the survival rate of advanced HCC patients treated with systemic chemotherapy remains unsatisfactory. Hence, the identification of novel molecular targets and the underlying mechanisms of chemoresistance in HCC and the development more effective therapeutic regimens are desperately needed. Methods An MTT assay was used to determine the cell viability after cisplatin or doxorubicin treatment. Western blotting, qRT‒PCR and immunohistochemistry were utilized to examine the protein tyrosine phosphatase IVA3 (PTP4A3) level and associated signaling pathways. ELISA was utilized to analyze the levels of the inflammatory cytokine IL-6 influenced by cisplatin, doxorubicin and PTP4A3 silencing. Results In this study, we found that PTP4A3 in the cisplatin/doxorubicin-resistant microarray was closely associated with the overall and recurrence-free survival rates of HCC patients. Cisplatin or doxorubicin significantly reduced cell viability and decreased PTP4A3 expression in hepatoma cells. IL-6 secretion increased with cisplatin or doxorubicin treatment and after PTP4A3 silencing. Furthermore, PTP4A3 was highly expressed in tumor tissues versus adjacent normal tissues from HCC patients. In addition, we evaluated the IL-6-associated signaling pathway involving STAT3 and JAK2, and the levels of p-STAT3, p-JAK2, STAT3 and JAK2 were obviously reduced with cisplatin or doxorubicin treatment in HCC cells using Western blotting and were also decreased after silencing PTP4A3. Collectively, we suggest that cisplatin or doxorubicin decreases HCC cell viability via downregulation of PTP4A3 expression through the IL-6R-JAK2-STAT3 cascade. Discussion Therefore, emerging evidence provides a deep understanding of the roles of PTP4A3 in HCC cisplatin/doxorubicin chemoresistance, which can be applied to develop early diagnosis strategies and reveal prognostic factors to establish novel targeted therapeutics to specifically treat HCC.
Perceived Barriers and Intentions to Receive COVID-19 Vaccines: Psychological Distress as a Moderator

A high vaccination uptake degree is crucial to achieve herd immunity to COVID-19 and restrict the spread of the COVID-19 pandemic. However, little is known about the antecedents that reduce or contribute to shaping the intention to receive COVID-19 vaccines, as well as how psychological distress—a mental health problem—can reinforce or dampen the translation from antecedents into intention to receive COVID-19 vaccines. The objective of this study was to explore the effects of perceived clinical and access barriers, self-efficacy, and attitudes towards COVID-19 vaccines on the intention to receive COVID-19 vaccines. Simultaneously, the moderation effects of psychological distress on this relationship were also examined. Using a sample of 2722 Vietnamese adults and structural equation modeling (SEM), this study illustrated that self-efficacy and attitudes towards COVID-19 vaccines were significantly interrelated with intention to receive COVID-19 vaccines. Self-efficacy, attitudes towards COVID-19 vaccines, and intention to receive COVID-19 vaccines were negatively influenced by perceived access barriers but were positively associated with perceived clinical barriers. Importantly, our study reported that when psychological distress was higher, the link between self-efficacy and intention to receive COVID-19 vaccines will become weaker, but the effect of perceived clinical barriers on intention to receive COVID-19 vaccines will be reinforced. Moreover, self-efficacy and attitudes towards COVID-19 vaccines served as mediators in the linkages between perceived barriers and intention to receive COVID-19 vaccines. Besides providing contributions to the extant COVID-19 vaccine literature, this study provides useful recommendations for practitioners and policymakers to foster adults’ COVID-19 vaccine acceptance.
Long-Interval Intracortical Inhibition and the Cortical Silent Period in Youth

Background: The cortical silent period (CSP) and long-interval intracortical inhibition (LICI) are putative markers of γ-aminobutyric acid receptor type B (GABAB)-mediated inhibitory neurotransmission. We aimed to assess the association between LICI and CSP in youths. Methods: We analyzed data from three previous studies of youth who underwent CSP and LICI measurements with transcranial magnetic stimulation and electromyography. We assessed CSP and LICI association using Spearman rank correlation tests and multiple linear regression analyses adjusted for demographic and clinical covariates. Results: The sample included 16 healthy participants and 45 participants with depression. The general mean (SD) age was 15.5 (1.7), 14.3 (1.7) for healthy participants, and 15.9 (1.6) years for participants with depression. Measures were nonnormally distributed (Shapiro–Wilk, p < 0.001). CSP and LICI were not correlated at 100-millisecond (ρ = −0.2421, p = 0.06), 150-millisecond (ρ = −0.1612, p = 0.21), or 200-millisecond (ρ = −0.0507, p = 0.70) interstimulus intervals using Spearman rank correlation test. No correlations were found in the multiple regression analysis (p = 0.35). Conclusions: Although previous studies suggest that cortical silent period and long-interval intracortical inhibition measure GABAB receptor-mediated activity, these biomarkers were not associated in our sample of youths. Future studies should focus on the specific physiologic and pharmacodynamic properties assessed by CSP and LICI in younger populations.
Influence of aspect ratio on tumbling plates

Abstract The tumbling motion of freely falling plates with aspect ratio ranging from 2 to 10 is studied using both experimental measurement and simplified lifting line theory. The trajectories of plates are recorded by high-speed video camera and analysed to obtain instantaneous and average kinematic and aerodynamic parameters, including the descent angle, rotating speed, descent velocities, lift and drag coefficients, and their fluctuation spectrums. A double period rotation with period doubling is observed here for some range of aspect ratio and the double frequency is determined from a Fourier analysis. By adding a correction from the inducing effect of trailing vortices and wing-tip vortices to the corresponding two-dimensional force and torque expressions, a simplified kinematic model is obtained which successfully predicts the qualitative influence of aspect ratio on the averaged kinematics, that the descent angle and the vertical descent velocity component are decreasing functions of the aspect ratio, while the rotation speed and horizontal velocity component are increasing functions of the aspect ratio. For decreasing aspect ratio, the induced drag due to the trailing and tip vortices reduces the lift to drag ratio and thus increases the descent angle, while the dissipative torque due to translational induced drag decreases the rotation speed.
Improving Learning and Study Strategies in Undergraduate Medical Students: A Pre-Post Study

We aimed to describe the impact of a structured interventional program to improve learning and study skills in undergraduate medical students from a Latin American medical school. The interventional program’s design was based on diagnostic/prescriptive assessment test scores measuring ten scales. The program consisted of five tailored workshops. The cohort studied consisted of 81 third-year medical students. The outcome variable was the difference between “pre” and “post” test scores. The unadjusted score percentiles were used to compare improvement in learning and study skills. In addition, a sensitivity analysis was conducted to assess variation in the mean difference of the test scores by the number of workshops attended. The response rate was 100% (81/81) for the pre test and ~77% (62/81) for the post test. After the interventional program, nine out of ten scales showed statistical improvement, except for the scale of motivation. The scales with the highest and lowest percent change improvement were time management (66%, p-value: <0.001) and motivation (14.9%, p-value: 0.06). The students who attended more workshops obtained a higher percent change improvement in the post test. These findings suggest that through a well-designed interventional program, it is possible to improve learning and study skills among medical students.
Quantitation of PET data with the EM reconstruction technique

The capability of a modified EM (expectation maximization) algorithm to quantify image data has been tested in phantom studies and in two clinical cases, cerebral blood flow studies and dopamine D2-receptor studies. Data from phantom studies indicate the superiority of images reconstructed with the EM technique compared to images reconstructed with the conventional filtered back-projection (FB) technique in areas with low statistics. At higher statistics the noise characteristics to the two technique coincide. Clinical data support these findings. Functional image data were generated regarding cerebral blood flow and receptor/dissociation constant (B/sub max//kD). The functional data based on EM reconstructed images show generally less noise and higher spatial resolution than functional data generated by FB reconstructed images. >
Sharing preparation contextuality in a Bell experiment by an arbitrary pair of sequential observers

Based on the quantum violation of bipartite Bell inequality, it has been demonstrated that the sharing of non-locality can be demonstrated for at most two sequential observers at one end and at most one-pair of observers at both ends. In this work, we study the sharing of non-locality and preparation contextuality based on a bipartite Bell inequality, involving arbitrary $n$ measurements by one party and $2^{n-1}$ measurements by other party. Such a Bell inequality has two bounds, the local bound and the preparation non-contextual bound, which is smaller than the local bound. We show that while non-locality can be shared only by first pair of the sequential observers, the preparation contextuality can be shared by arbitrary pair of independent sequential observers at both ends.
Robust Gridless Estimation of Angles and Delays for Full-Dimensional Wideband mmWave Channels

In this paper, we consider robust channel estimation for a millimeter wave (mmWave) massive MIMO system with uniform planar arrays (UPA). For many gridless angle estimation methods of mmWave channels, the channel gains needs to be time-invariant during training. We propose a gridless method that is applicable to time-invariant and time-varying channels, and the proposed method is robust to channel variations. This is done by employing time-varying precoders and combiners that are banded block Toeplitz (BBT) matrices. The advantage of time-varying BBT precoders is two-fold. First, with time-varying BBT precoding we can fabricate time-varying channels. Thus the channel can be estimated as if it is a time-varying channel whether the actual channel is time-varying or not. We will show that, thanks to fabricated time variation in the channel, a small training overhead can be used. Secondly, BBT precoding and combining preserve the shift invariance property of the received data matrix. Due to the preservation of shift invariance property, we can employ most existing direction finding methods for estimating the angles and delays, including low complexity gridless subspace based algorithms. Simulation results are given to show that the proposed time-varying BBT precoding provides robust and accurate channel estimates with a low complexity.
Some properties of the control operator in the problem of data assimilation and iterative algorithms

In this paper we study the simplest problem of data assimilation for a linear evolutionary problem in which the initial condition is not known. We have, investigated the properties of the control operator, formulated the necessary and sufficient conditions for solvability of the problem, studied the class of iterative methods for solving the problem and the conditions for their convergence. The results are closely connected with some issues raised in [1,9,10]. 1. POSING THE PROBLEM AND THE MAIN ASSUMPTIONS In the past few years interest has been expressed in the problems of assimilation and processing of the measurement data in various areas of knowledge. These problems can be formulated mathematically as problems of optimal control. Beginning with the works of Pontryagin [13], Bellman [3], Marchuk [8], Krasovskii [5], Lions [7], Glowinski [4], Balakrishnan [2], posing and studying such problems on the basis of the adjoint equation theory have attracted the attention of many researchers. Let us describe the formulation of the problem and the main assumptions. Let H and V be real Hubert spaces such that V is compactly imbedded in //, and H\ V* are dual spaces to H and V. We consider the spaces L2(0,T;//), L2(0,T;F), L2(0,T;K*) of functions
Body Composition Parameters Correlate to Depression Symptom Levels in Patients Treated with Hemodialysis and Peritoneal Dialysis

The aim of this study was to investigate the determinants of depression and nutritional status and their associations in patients treated with hemodialysis (HD) and peritoneal dialysis (PD) and the differences according to the type of treatment. There were fifty-three patients treated with maintenance HD and twenty patients treated with PD enrolled in this cross-sectional study. Body composition, anthropometric parameters, and clinical and laboratory parameters were collected for each participant. Depression was assessed with the Beck Depression Inventory II (BDI-II) and risk of malnutrition with the Malnutrition Inflammation Score (MIS). The results suggest a positive association between the level of depression and the percentage of fat mass and obesity parameters in PD and HD participants. Muscle mass and fat-free mass in HD, phase angle (PhA), and serum albumin levels in PD were negatively associated with the value of BDI-II. Participants treated with HD were found to have higher levels of pessimism and loss of interest in sex compared with PD. There is a need to integrate multidisciplinary psychological and nutritional assessment into the usual care of dialysis patients.
An Endless Optical Phase Delay for Harmonic-Free Phase/Frequency Shifting in Coherent-Lite DCIs and Microwave Photonics

An optical IQ modulator (IQM), when driven by quadrature-phase sinusoidal electrical signals, adds a phase/frequency offset to the optical input. However, harmonics of the applied electrical signals are also generated in the optical domain. In this work, we analytically derive the waveform shapes that achieve a harmonic-free phase/frequency shift with high spectral purity using the IQM. Using these waveforms, an endless optical phase delay (EOPD), wherein the phase delay can be increased or decreased continuously and arbitrarily in a reset-free manner, has been presented. The EOPD can be used in coherent-lite or analog coherent receiver based DCIs, phased array LiDAR, and many other applications. In order to adjust for the bias voltages and control signal gains in the EOPD, some of which may be time varying, a multivariate gradient descent algorithm is presented. Use of the EOPD for phase synchronization in a self-homodyne coherent-lite optical link has been demonstrated, making it a promising solution for low-power high-capacity coherent data center interconnects (DCIs).
Effectiveness of Repeated Stereotactic Body Radiation Therapy for Hepatocellular Carcinoma—Consideration of the Locations of Target Lesions

Simple Summary Many treatment options are available for hepatocellular carcinoma. Radiation therapy is one of the local options, along with surgery and radiofrequency ablation. Stereotactic body radiation therapy is an effective therapy for hepatocellular carcinoma that provides good outcomes with tolerable toxicities and has been recognized as a local therapy for patients who are ineligible for surgery or radiofrequency ablation. Hepatocellular carcinoma tends to recur, so stereotactic body radiation therapy is also used for recurrent cases. However, few reports have summarized local tumor control, transition of liver function, and side effects in cases of repeated stereotactic body radiation therapy. This study retrospectively evaluated the efficacy of stereotactic body radiation therapy, including repeated radiation therapy, for hepatocellular carcinoma. Abstract The present study retrospectively evaluated the efficacy of stereotactic body radiation therapy (SBRT), including repeated SBRT, for hepatocellular carcinoma. Participants comprised 220 HCC patients treated with SBRT in Hiroshima University Hospital between December 2008 and December 2021. Median overall survival (OS) and disease-free survival were 52 months (range, 45–64 months) and 17 months (range, 14–23 months), respectively. The 5-year local tumor recurrence rate was 3.4% (95% confidence interval (CI), 1.3–6.9%). Fifty-three patients underwent repeated SBRT (twice, 53 cases; three times, 10 cases; four times, 4 cases; five times, 1 case). Median interval between first and second SBRT was 20 months. Median OS from first SBRT was 76 months (95% CI, 50–102 months). Among patients with repeated SBRT, only one case showed local recurrence after second SBRT. Albumin–bilirubin score increased significantly from 6 to 12 months after repeated SBRT, both in the same segment and in remote segments, but the increase was not significant in the same segment. Only one case of grade 3 bile duct stricture was observed in patients who were treated with repeated SBRT. In conclusion, repeated SBRT provides good local control and a low risk of side effects.
Detection of Diabetics Using Support Vector Machine Algorithm in Comparison With K Nearest Neighbour Algorithm to Measure Accuracy, Sensitivity and Specificity

The aim of this article is to measure the performance metrics of an accuracy, sensitivity and specificity of the Novel Support Vector Machine (SVM) algorithm for diabetics detection and compared with a K Nearest Neighbour (KNN) algorithm. Materials and Methods: A total of 768 samples are collected from diabetics detection datasets found in kaggle. These samples are divided into a training dataset (n=500) and test dataset (n=268). Results: By comparing the Novel Support Vector Machine with KNN. The SVM has achieved better accuracy and specificity than the KNN and the KNN has better Sensitivity than the SVM algorithm. The output values of accuracy, specificity and sensitivity of the SVM are 79%, 93% and 58%. The output values of accuracy, specificity and sensitivity of the KNN algorithm are 63%, 39% and 100%. The significance value is Pi0.05. The G power is taken as 0.8. Conclusion: The output values of accuracy, specificity and sensitivity of the Novel SVM are 79%, 93% and 58%. The output values of accuracy, specificity and sensitivity of the KNN algorithm are 63%, 39% and 100
Spatially and Temporally Confined Response of Gastrointestinal Antibiotic Resistance Gene Levels to Sulfadiazine and Extracellular Antibiotic Resistance Gene Exposure in Mice

Simple Summary The emergence of bacterial resistance to antibiotics is a significant threat to human health, because it makes controlling bacterial infection more difficult. Antibiotic resistance genes that can cause bacteria to resist antibiotics are ubiquitous in the environment and consumed daily by humans via food and water. It has long been suspected that uptake of these genes may lead to increased antibiotic resistance in bacteria that colonize human bodies, which in turn may lead to infections that are hard to cure. In addition, the uptake of antibiotics may also lead to an increase in antibiotic resistance, resulting in negative impacts for further treatment. To address these concerns, we applied an in vivo study to determine how the antibiotic resistance levels in the gastrointestinal tracts of mice models react to uptake of antibiotics and antibiotic resistance genes. With quantitative analysis, both antibiotics and antibiotic resistance genes were found to indeed increase antibiotic resistance levels. However, this response was found to be both temporally and spatially confined: they are acute responses that only occur 12–16 days after exposure, and they only occur in certain segments of the gastrointestinal tract. This work further suggests caution over antibiotic resistance gene pollution and antibiotic misuse. Abstract This work aims to investigate the impact of antibiotics and extracellular antibiotic resistance genes (eARGs) on the dynamics of gastrointestinal antimicrobial resistance (AMR). The antibiotic resistance gene (ARG) levels of different segments of the gastrointestinal tract of mouse models were analyzed and compared after exposure to clinical concentrations of sulfadiazine and environmental levels of eARGs carried by the conjugative plasmid pR55. Exposure to sulfadiazine and eARGs led to significant changes in ARG levels by as many as four log-folds. Further analysis showed that the response of ARG levels appeared from 12–16 days after exposure and diminished 20 days after exposure. The responses in ARG levels were also restricted to different gastrointestinal segments for sulfadiazine and eARGs. Combined exposure of sulfadiazine and eARGs was unable to further increase ARG levels. From these findings, we concluded that the short-term consumption of environmental levels of eARGs and uptake of clinical levels of antibiotics lead to a spatially and temporally confined response in gastrointestinal AMR. These findings further clarify the detrimental impacts of antibiotic and eARG uptake, and the complexity of AMR development and dissemination dynamics in the gastrointestinal tract.
Adaptive output feedback stabilization for a class of nonlinear systems with inherent nonlinearities and uncertainties

This paper investigates the problem of adaptive stabilization by output feedback for a class of uncertain nonlinear systems. The distinguishing feature of such a class of systems is the presence of uncertain control coefficient and unmeasured states dependent growth with growth rate of polynomial‐of‐output multiplying an unknown constant. First, new high‐gain K‐filters with two dynamic gains are introduced, and an appropriate state observer is constructed based on the K‐filters. Then, motivated by the universal control idea, the backstepping scheme is successfully developed for the adaptive output feedback control design. By appropriate choice of the design parameters, the global stability of the closed‐loop system can be guaranteed. Finally, numerical simulations are provided to illustrate the correctness of the theoretical results. Copyright © 2010 John Wiley & Sons, Ltd.