Miracle-dz/UniFAR-FTUs huggingface dataset:
Toxicity and teratogenicity evaluation of ethanolic extract from Momordica charantia fruit using zebrafish (Danio rerio) embryo model

Zebrafish (Danio rerio), a freshwater fish, has become a favoured animal model to assess the teratogenicity effects of various compounds. Momordica charantia is a fruit traditionally used as a functional food to treat various ailments. In the present work, 80% ethanolic extract of M. charantia fruit was investigated for its teratogenicity effects on the zebrafish embryos. The embryos of 12 h post-fertilisation were immersed in the ethanolic extract at various concentrations of 250, 500, 750, 1,000, and 1,250 mg/L prepared in 2% DMSO. Microscopic observation was carried out every 24 h. Results showed an increased mortality rate, and a delayed hatching rate with increasing concentration. Some of the deformities observed included hyperactivity, crooked backbone, reduced pigmentation, awkward positioning, and coagulation at the highest concentration. Probit analysis resulted in 725.90 mg/L as the median lethal concentration (LC50). Chromatographic analysis revealed the presence of propanedioic acid, malic acid, contrunculin-A, glutamine, D-fructose, sorbopyranose, xylitol, galactonic acid, D-mannitol, and mannose. These compounds may contribute to the deformities observed in a concentration-dependent manner. Therefore, M. charantia fruit must be consumed with caution and within the recommended amount.
The impact of court-ordered psychiatric treatment on hospital length of stay: balancing legal and clinical concerns.

Purpose Psychiatric hospital length of stay (LOS) is not affected solely by socio-clinical factors but also by legal procedures. This study examined the associations between legal procedures and LOS. Methods Data from 521 patients with psychiatric illnesses hospitalized over 2013-2015 were analyzed. Logistic regression was used to evaluate the predictors of longer (> 14 days) or prolonged (> 30) LOS with socio-clinical factors and legal procedures including court-ordered interventions (assisted outpatient treatment, medication over objection, and retention). Results Longer LOS occurred in 246 patients and 99 had prolonged LOS. Legal procedures affected 57 patients, with 11 assisted outpatient treatments, 39 cases of medication over objection, and 16 retentions. Longer LOS was significantly associated with six factors including older age, unmarried status, non-Hispanic race, risk of violence, schizophrenia, and legal procedures. Legal procedures had the strongest association. Longer/prolonged LOS yielded qualitatively similar associations. Conclusion Among 521 psychiatric inpatients, approximately 11% were mandated to receive interventions/procedures by the courts. Court-ordered legal procedures were strongly associated with longer LOS. Mental health providers may consider legal procedures for patients at high treatment/medication noncompliance risk as early as patient admission to inpatient units to prevent, intervene or prepare for a longer or prolonged LOS.
Behavior of Sheared Granular Materials at Micro-Scale during the Cyclic Loading

The aim of this paper is to explore the evolution of diﬀerent micro-scale quantities during the cyclic loading using the discrete element method (DEM) for a granulate system such as sand. The numerical samples comprising of 9826 spheres were generated and consolidated isotropically using the periodic boundaries. These numerical samples were subjected to the cyclic loading for diﬀerent maximum applied strains. The simulated stress-strain behavior was validated with the experiment and found an excellent agreement between them during loading and unloading. The evolutions of diﬀerent micro-scale quantities were investigated in detail considering the variation of the maximum applied strain and the density of sample. It is noted that the evolution of the coordination number and the slip coordination number is a function of the maximum applied strain and the density of sample during the cyclic loading. The change of the slip coordination number is larger at the end of unloading than that at end of loading during the cyclic loading regardless of the values of the maximum applied strain and the density of sample. The ratio of strong contacts to all the contacts increases abruptly when the load is reversed, which is opposite to what is observed for the coordination number and the slip coordination number. The deviatoric fabric computed by the fabric tensor considering the strong contacts mimics the deviatoric stress irrespective of the values of the maximum applied strain and the density of sample during the cyclic loading. Moreover, a linear correlation between the macro and micro quantities exists regardless of the variation of the maximum applied strains or the variation of the density of the sample during the cyclic loading. The slopes of the lines of these correlations are almost same.This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium provided the original work is properly cited.
AISeL ) All Sprouts Content Sprouts 11-25-2011 Measuring the Impact of Organizational Social WebSite Usage on Work Performance : A MultilevelModel

This paper describes the development of a multilevel model for investigating the impact of organizational social web site (SWS) usage on individual and team performance. Despite the SWS focus on collective phenomena such as crowd sourcing and collective intelligence previous research on SWS usage in general does not investigate it as a multilevel phenomenon. Our paper addresses this gap by drawing on existing guidelines for multilevel theorizing. We thus propose that SWS usage impacts individual and team performance through its improved collaboration capabilities. Organizational learning and social capital theories serve as the theoretical foundation. Ultimately, we present a multilevel model as the foundation for future empirical research on SWS usage's impact on individual and team performance. Our research's contribution lies in the theoretical derivation of a multilevel model.
Rodent peri-implantitis models: a systematic review and meta-analysis of morphological changes

Purpose Rodent models have emerged as an alternative to established larger animal models for peri-implantitis research. However, the construct validity of rodent models is controversial due to a lack of consensus regarding their histological, morphological, and biochemical characteristics. This systematic review sought to validate rodent models by characterizing their morphological changes, particularly marginal bone loss (MBL), a hallmark of peri-implantitis. Methods This review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. A literature search was performed electronically using MEDLINE (PubMed), and Embase, identifying pre-clinical studies reporting MBL after experimental peri-implantitis induction in rodents. Each study’s risk of bias was assessed using the Systematic Review Center for Laboratory animal Experimentation (SYRCLE) risk of bias tool. A meta-analysis was performed for the difference in MBL, comparing healthy implants to those with experimental peri-implantitis. Results Of the 1,014 unique records retrieved, 23 studies that met the eligibility criteria were included. Peri-implantitis was induced using 4 methods: ligatures, lipopolysaccharide, microbial infection, and titanium particles. Studies presented high to unclear risks of bias. During the osseointegration phase, 11.6% and 6.4%-11.3% of implants inserted in mice and rats, respectively, had failed to osseointegrate. Twelve studies were included in the meta-analysis of the linear MBL measured using micro-computed tomography. Following experimental peri-implantitis, the MBL was estimated to be 0.25 mm (95% confidence interval [CI], 0.14–0.36 mm) in mice and 0.26 mm (95% CI, 0.19–0.34 mm) in rats. The resulting peri-implant MBL was circumferential, consisting of supra- and infrabony components. Conclusions Experimental peri-implantitis in rodent models results in circumferential MBL, with morphology consistent with the clinical presentation of peri-implantitis. While rodent models are promising, there is still a need to further characterize their healing potentials, standardize experiment protocols, and improve the reporting of results and methodology. Trial Registration PROSPERO Identifier: CRD42020209776
Non‐Gaussian Distributions of TOA SW Flux as Observed by MISR and CERES

The Top of Atmosphere (TOA) shortwave (SW) flux, converted from Terra Multi‐angle Imaging SpectroRadiometer (MISR) narrow band albedos, is compared with that measured from Clouds and the Earth's Radiant Energy System (CERES). We describe the probability density function (PDF) of the monthly TOA SW flux and how the statistical third moment, skewness, can impact the quantification of the flux. The PDF of the SW flux is not normally distributed but positively skewed. In both sets of observations, the near‐global (80 S–80 N) median value of the SW flux is ∼3 W/m2 less than the mean value, due to the positive skewness of the distribution. The near‐global mean TOA SW flux converted from MISR is about 7 W/m2 (∼7%) less than CERES measured flux during the last two decades. Surprisingly, a hemispheric asymmetry exists with TOA SW observations from the Terra platform. SH reflects 3.92 and 1.15 W/m2 more mean SW flux than NH, from MISR and CERES Single Scanner Footprint products, respectively. We can infer that the offsetting by morning clouds in the SH is greater than the effect of hemispheric imbalance of SW flux caused by different land masses in two hemispheres. While the characteristics of the two SW fluxes broadly agree with each other, differences in the regional PDF from two different SW fluxes are substantial over high cloud regions and high altitude regions. Our analysis shows that some parts of the different skewness from the two measurements may be attributed to the different calibration of the radiance anisotropy over high cloud scenes.
Determination of starch and amylose contents in various cereals using common model of near-infrared reflectance spectroscopy

Near-infrared reflectance spectroscopy (NIRS) was used to determine the total starch and amylose contents in various kinds of cereals namely wheat, waxy rice, non-waxy rice, millet, sorghum, waxy maize, buckwheat, barley, and hulless oat. The partial least-squares (PLS) analysis and principal component regression (PCR) were used to establish the calibration models. PLS model achieved a better effect than PCR at 1100 - 2500 nm, and the coefficient of determination (R2) of the calibration and prediction sets were both higher than 0.9 after the best pre-treatment method, first derivative plus Savitzky-Golay. Additionally, the root mean square error (RMSE) was lower than 2.50, and the root mean square error of cross-validation (RMSECV) was less than 3.50 for starch. By comparing PLS models at different waveband regions, the optimal determination results for starch and amylose were obtained at 1923 - 1961 and 1724 - 1818 nm, respectively. NIRS was found to be a successful method to determine of the starch and amylose contents in various cereals.
Quality of care provided to diabetic patients attending primary health care centers in National Guard in Makkah Region, Saudi Arabia

Background: Diabetes is a costly and serious health problem that is increasing markedly. The quality of care is a major issue among diabetic patients. This study aims to assess the quality of care provided to diabetic patients using the American Diabetes Association (ADA) indicators. Methods: This was a cross-sectional study conducted using a retrospective chart review. The population was adult diabetic patients (type 2) who had attended the National Guard's primary healthcare centers, Makkah region, Saudi Arabia, from January 1, 2017, to December 31, 2018. Results: We studied 400 adult diabetic patients aged 30–97 years with a mean age of 58.25 (SD = 11.9). The length of time with diabetes ranged from 1 to 42 years with a mean of 9.66 years (SD = 7.6). Among all the primary healthcare centers (PHCs), specialized polyclinic (SPC) had the highest number of patient visits. Furthermore, the SPC had the highest number of patients with complications; the primary healthcare center with the fewest complications was Iskan-Jeddah. The results show that the control of hemoglobin A1C (HbA1C) was better in 2018 than in 2017. Conclusion: There is improved and adequate care provided to patients among the assessed primary healthcare centers in the Makkah region. Nevertheless, there remains a need for interventions to maintain comprehensive data on diabetes performance. Monitoring and proper education on diabetic care to patients are suggested to achieve better control of diabetes and delay the occurrence of complications.
The Influence of Critical Audit Matters in the US on the Informativeness of Investors

In 2017, the PCAOB announced its new audit standard, AS 3101. One requirement is reporting critical audit matters (CAMs), starting June 30, 2019, for large accelerated filers. Using US data of CAM, we investigate whether the reporting of CAMs is informative for investors using a difference-in-differences approach and we use as proxies for investors’ informativeness, absolute abnormal returns and abnormal trading volume. Our motivation is to assess the relevance and the effectiveness of a new regulation aiming to improve audit quality. Overall, our findings provide some indications that the first-time implementation of CAMs might lead to investors avoiding those companies presumably because of uncertainty about the information being released. We also investigate the content of the CAM paragraph and do not find that the number, categories, or firm-specific/industry-common CAMs are value-relevant for investors. The results of this study provide insight into the new US auditor standard and the value-relevance of CAMs for investors. We suggest that standard setters should aim to improve the auditor report to make it more informational. Overall, our paper provides some evidence on the implementation and communicative value of the new CAM reporting, suggesting that CAMs are not informative for investors. We argue that this is the case potentially due to the additional information from CAMs which leads to complex information or information overload making investors less reluctant to invest on the companies with a significant number of CAMs reported.
ANDROPAUSE REPRESENTATIONS: A MIXED-METHODS STUDY WITH PORTUGUESE WOMEN

: Since psychosocial factors have some impact on andropause, and this phenomenon can affect conjugal relationships (and women tend to be health information seekers) it becomes important to study the representations of andropause using the Common-Sense Model – a model used to understand the representations of menopause. This research aimed to assess Portuguese women’s representations of andropause, the suitability of the Common-Sense Model in explaining those representations, and to explore differences among participants with different characteristics (e.g., level of education), regarding andropause representations. Interviews to 30 women were analysed (directed qualitative content analysis). A multiple correspondence analysis explored the association between the emergent categories. Mann-Whitney U tests were performed to test differences regarding the frequency of emergent categories. Undefined identity was the most frequently mentioned feature regarding andropause Identity , whereas Sexual Function was the most mentioned Negative Consequence ; few Positive Consequences were mentioned, being the Absence of positives consequences and the Lack of information the most frequent ones. Two bidimensional models were found - one for Identity of andropause: (1) Aging related changes, and (2) Sexual changes/lack of information; the other for Negative Consequences : (1) Symptoms/health problems, and (2) Depression/lack of information. No differences were found in the frequency of andropause representations between women with different characteristics (e.g., with a romantic relationship vs. without a romantic relationship). The suitability of the Common-Sense Model to explain these women’s andropause representations did not differ among participants with distinctive characteristics. This research may help healthcare professionals to develop comprehensive interventions (based on this theoretical model) in order to help couples to better understand and cope with andropause.
Characterization of the Genetic Variability in Rice (Oryza sativa L.) and its Assessment Using Principal Component Analysis (PCA)

Present investigation was conducted to estimate genetic parameters such as Genotypic Coefficient of Variation (GCV), Phenotypic Coefficient of Variation (PCV), heritability and Genetic Advance (GA) along with correlations, path coefficients, Genetic divergence and Principal Component Analysis (PCA) from data collected on 21 rice genotypes. The results revealed highly significant mean squares due to genotypes for all traits studied, indicating the existence of sufficient variation among the genotypes and therefore an ample scope for effective selection. High PCV, GCV, heritability and genetic advance as per cent of mean was observed for 1000-grain weight, seed yield per plant, and harvest index, indicating the effectiveness of direct selection for improvement of these traits. Thousand grain weight and harvest index had recorded positive and significant association with seed yield per plant. The results on path analysis also revealed high and positive direct effect for harvest index followed by flag leaf width, days to 50% flowering, days to maturity, plant height, panicle length, number of filled grains/panicle, number of spikelets/panicle and hence, these traits were identified as the most effective selection criteria for improvement of seed yield per plant in rice genotypes. The results on divergence analysis revealed that the genotypes were grouped into five clusters. Cluster I constituted maximum number of (17) genotypes. Maximum differences among the genotypes within the same cluster (intra-cluster) were shown by cluster I (18.33) followed by cluster II, III, IV, V showed zero intra -cluster distance. Cluster III and V (37.41) showed maximum inter cluster distance, suggesting that the genotypes constituted in these clusters may be used as parents for future hybridization programme. Principal Component Analysis (PCA) was utilized to estimate the relative contribution of various traits for total variability. Five components were found to possess eigen value more than 1.00. The PC1, PC2, PC3, PC4 and PC5 contributed 31.2, 14.5, 12.6, 10.5 and 10.1 per cent of variability. Together, they accounted for 78.9% of the variability of the genotypes used in the study has revealed the traits contributing for the variation.
Arsenate removal from aqueous solutions by Mg/Fe-LDH-modified biochar derived from apple tree residues

ABSTRACT The development of non-toxic and inexpensive materials for arsenic removal is required due to water sources being polluted by arsenic in many countries around the world. The main aim of this study was to characterise the capacity and behaviour of Mg/Fe layered double hydroxides/biochar [Magnesium/Iron-Layered Double Hydroxide (Mg/Fe-LDH)] composite for arsenate adsorption from solution. Apple tree pruning residues were used to produce biochar at 500 °C under oxygen-limited atmosphere. Mg/Fe-LDH-biochar was synthesised using a spontaneous in situ co-precipitation method. Batch experiments were used for the assessment of the kinetics, isotherms, and the effects of initial solution pH (4, 6, 8, and 10), ionic strength (0.01, 0.1, and 0.2 mol L−1), and co-occurring anions (carbonate and phosphate) on the arsenate removal. Scanning electron microscope images showed Mg/Fe-LDH were loaded on the biochar porous structure, and X-ray diffraction analysis affirmed the presence of crystalline LDH minerals in Mg/Fe-LDH-biochar. Surface modification of biochar by Mg/Fe-LDH increased the maximum arsenate adsorption capacity (3.6 mg g−1) ten times compared to unmodified biochar (0.35 mg g−1). Arsenate removal capacity increased from 4.2 % to 54.2 % with modification of biochar by Mg/Fe-based LDH. Kinetic studies indicated that >90 % of Mg/Fe-LDH-biochar arsenate adsorption from a starting concentration of 10 mg L−1 occurred in the first 120 min. Pseudo-second order and Langmuir models described well the kinetics and isotherm of arsenate adsorption by biochar and Mg/Fe-LDH-biochar. Mg/Fe-LDH-biochar showed maximum arsenate removal capacity at pH 6. Increasing solution ionic strength and the presence of phosphate and carbonate anions suppressed arsenate removal by Mg/Fe-LDH-biochar. In summary, surface modification of biochar using Mg/Fe-LDH produced a potentially more cost-effective, locally available, reusable, and non-toxic arsenic adsorbent for decontamination of surface- and groundwater.
Acute Hepatic and Renal Toxicity Assessment of Euphorbia huanchahana (Klotzsch & Garcke) Boissier (Huachangana) in Holtzman Rats

Background: Euphorbia huachahana (Klotzch & Garcke) Boissier (Huachangana) (EhKGBh) has been used for over a century for medicinal purposes in the Peruvian population; however, its safety and possible toxic effects of use have not been reported. The purpose of this study was to determine the acute hepatic and renal toxicity of EhKGBh in Holtzman rats. Methods: Analytical and experimental study. The population consisted of 52 rats of both sexes weighing between 300 and 350 g divided into four groups: G1 and G2 EhKGBh groups (26 rats each) and two control groups (10 rats each). The experimental group was administered EhKGBh at a single dose of 2000 mg/kg P.O. to demonstrate toxicity during the 14-day follow-up. A daily assessment of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), total bilirubin (TBIL), and conjugated bilirubin (CBIL) was performed. Results: Evaluation of the liver tissue showed mild changes in inflammation, predominantly vascular, with small clots. Kidney tissue did not show inflammatory or necrotic changes. However, we showed differences in the weight of the rats between both groups (p < 0.004) and significant increases in TBIL (0.98–1.07 mg/dL), CBIL (0.43–0.45 mg/dL), AST (126.4–141.8 U/L), and ALP (254–298 U/L) but not ALT (39.7–41.1 U/L) (p < 0.05). Conclusion: The single dose of EhKGBh extract at 2000 mg/kg has no toxicity, and there is no change in tissue toxicity during the 14-day follow-up.
Fast and direct visualization of piezo-generated charges at the nanoscale using direct piezoelectric force microscopy

The denominated surface charge scraping mechanism was discovered in 2014 by using a new Atomic Force Microscopy (AFM) based mode called Charge Gradient Microscopy. The measurements to probe such mechanism are achieved with the use of a current-to-voltage converter: a transimpedance amplifier (TIA). However, the use of an incorrect approximation, named Gain BandWidth Product (GBWP) to calculate TIAs BandWidth (BW) could mislead to an incorrect data interpretation. By measuring at higher frequencies than permitted, the amplifier is used as a current-to-voltage converter, in conditions where it behaves as a charge-to-voltage converter. In this manuscript, we report the specific conditions in which the transfer function of the same electronic circuit topology is valid, while we spot both ringing and unstable amplifiers artifacts in the published data. We finally perform physical measurements in similar conditions as reported, but fully respecting the BandWidth (BW) of the system. We find that the charge collected is way below the values reported in such publication, diminishing or even nullifying the impact of a possible charge scrapping mechanism. These findings pave the way to employ Direct Piezoelectric Force Microscopy (DPFM) as a fast ferroelectric nanoscale characterization tool.