Miracle-dz/UniFAR-FTUs huggingface dataset:
Dielectric dispersion and critical behavior in relaxor ferroelectric Pb(Mg1/3Nb2/3)O3–PbTiO3

A critical behavior of dielectric susceptibility has been discovered in relaxor ferroelectric 0.75Pb(Mg1/3Nb2/3)O3–0.25PbTiO3. The real part of permittivity e′ was found to follow the relation e′−e∞=χ′∝(T−T0)−2 at T>T0, and e′∝(TC−T)−1 at T<TC, where T0≈TC<Tm; Tm is the temperature of the diffused e′(T) maximum as is typical of relaxors; e∞ is the frequency-independent parameter, and χ′ is the susceptibility depending on frequency via the “universal” relaxation law χ′∝fn−1. The susceptibility χ′ is suggested to originate from the polarization of polar nanoclusters.
Generating $\fnl$ at $\ell\lsim 60$

The CMB anisotropy at $\ell\lsim 60$ seems to have some special features which include (i) a dipole modulation and (ii) a decrease in power. It is known that both of these effects can be generated if a curvaton-type field has a super-horizon perturbation. It is also known that this will generate non-gaussianity $\fnl$ in the same range of $\ell$, whose magnitude has a lower bound coming from the magnitude of the observed CMB quadrupole. I revisit that bound in the present paper, and point out that it may or may not be compatible with current data which should therefore be re-analysed.
Adoption of Machine Learning in Pharmacometrics: An Overview of Recent Implementations and Their Considerations

Pharmacometrics is a multidisciplinary field utilizing mathematical models of physiology, pharmacology, and disease to describe and quantify the interactions between medication and patient. As these models become more and more advanced, the need for advanced data analysis tools grows. Recently, there has been much interest in the adoption of machine learning (ML) algorithms. These algorithms offer strong function approximation capabilities and might reduce the time spent on model development. However, ML tools are not yet an integral part of the pharmacometrics workflow. The goal of this work is to discuss how ML algorithms have been applied in four stages of the pharmacometrics pipeline: data preparation, hypothesis generation, predictive modelling, and model validation. We will also discuss considerations before the use of ML algorithms with respect to each topic. We conclude by summarizing applications that hold potential for adoption by pharmacometricians.
Protective Effect of Cashew Gum (Anacardium occidentale L.) on 5-Fluorouracil-Induced Intestinal Mucositis

Intestinal mucositis is a common complication associated with 5-fluorouracil (5-FU), a chemotherapeutic agent used for cancer treatment. Cashew gum (CG) has been reported as a potent anti-inflammatory agent. In the present study, we aimed to evaluate the effect of CG extracted from the exudate of Anacardium occidentale L. on experimental intestinal mucositis induced by 5-FU. Swiss mice were randomly divided into seven groups: Saline, 5-FU, CG 30, CG 60, CG 90, Celecoxib (CLX), and CLX + CG 90 groups. The weight of mice was measured daily. After treatment, the animals were euthanized and segments of the small intestine were collected to evaluate histopathological alterations (morphometric analysis), levels of malondialdehyde (MDA), myeloperoxidase (MPO), and glutathione (GSH), and immunohistochemical analysis of interleukin 1 beta (IL-1β) and cyclooxygenase-2 (COX-2). 5-FU induced intense weight loss and reduction in villus height compared to the saline group. CG 90 prevented 5-FU-induced histopathological changes and decreased oxidative stress through decrease of MDA levels and increase of GSH concentration. CG attenuated inflammatory process by decreasing MPO activity, intestinal mastocytosis, and COX-2 expression. Our findings suggest that CG at a concentration of 90 mg/kg reverses the effects of 5-FU-induced intestinal mucositis.
Planet-disk interaction: eccentricity excitation and orbital evolution

This thesis presents the results of numerical simulations on planets embedded in a protoplanetary disk with the hydrodynamics code NIRVANA. We treat the disk as a viscous fluid satisfying the Navier-Stokes equations and integrate these using a finite difference scheme. We present three sets of calculations. First our participation to the EU code comparison project is described. In this project we compare the results of a test problem relevant to planet formation as calculated by many different codes. In the second part we investigate a similar problem where we put a 5-Jupiter mass planet into the protoplanetary disk. After several hundred orbits the disk and the gap opened by the planet become eccentric. This periodic state is very robust and can be sustained indefinitely. Finally we look what happens to the eccentricity of the planetary orbit when the planet is allowed to change its orbit. For small planetary masses for which linear theory may be applied we find a rapid damping of both the eccentricity and inclination. We compare these results to linear theory and find good agreement. For the very massive planets that caused the eccentric disk we find a substantial increase of the eccentricity.
Magellan LDSS3 emission confirmation of galaxies hosting metal-rich Lyman α absorption systems

Using the Low Dispersion Survey Spectrograph 3 at the Magellan II Clay Telescope, we target {candidate absorption host galaxies} detected in deep optical imaging {(reaching limiting apparent magnitudes of 23.0-26.5 in $g, r, i,$ and $z$ filters) in the fields of three QSOs, each of which shows the presence of high metallicity, high $N_{\rm HI}$ absorption systems in their spectra (Q0826-2230: $z_{abs}$=0.9110, Q1323-0021: $z_{abs}=0.7160$, Q1436-0051: $z_{abs}=0.7377, 0.9281$). We confirm three host galaxies {at redshifts 0.7387, 0.7401, and 0.9286} for two of the Lyman-$\alpha$ absorption systems (one with two galaxies interacting). For these systems, we are able to determine the star formation rates (SFRs); impact parameters (from previous imaging detections); the velocity shift between the absorption and emission redshifts; and, for one system, also the emission metallicity. } Based on previous photometry, we find these galaxies have L$>$L$^{\ast}$. The [O II] SFRs for these galaxies are in the range $11-25$ M$_{\odot}$ yr$^{-1}$ {(uncorrected for dust)}, while the impact parameters lie in the range $35-54$ kpc. {Despite the fact that we have confirmed galaxies at 50 kpc from the QSO, no gradient in metallicity is indicated between the absorption metallicity along the QSO line of sight and the emission line metallicity in the galaxies. } We confirm the anti-correlation between impact parameter and $N_{\rm HI}$ from the literature. We also report the emission redshift of five other galaxies: three at $z_{em}>z_{QSO}$, and two (L$<$L$^{\ast}$) at $z_{em}
Immune-Related Uncommon Adverse Events in Patients with Cancer Treated with Immunotherapy

Immunotherapy has dramatically changed the therapeutic landscape of oncology, and has become standard of care in multiple cancer types in front or late lines of therapy, with some longstanding responses and outstanding results. Notwithstanding, its use has brought a totally unique spectrum of adverse events, characterized by a myriad of diverse manifestations affecting nearly every organ and system of the body, including the endocrine, nervous, cardiac, respiratory and gastrointestinal systems. Uncommon adverse events, defined as those occurring in less than 1% of patients, comprise an even more heterogeneous group of diseases that are being seen more recurrently as the use of immune check-point inhibitors increases and indications spread in different tumor types and stages. Here, we comprehensively review some uncommon, but exceedingly important, immune-related adverse events, with special emphasis in the clinical approach and diagnostic workup, aiming to reunite the evidence published previously, allowing an increase in awareness and knowledge from all specialists implicated in the diagnosis, treatment, and care of cancer patients treated with immunotherapy.
Postoperative Urinary Catheterization in Children Treated with or without Epidural Analgesia after Orthopedic Surgery: A Retrospective Review of Practice

Epidural analgesia is effective and an accepted treatment for postoperative pain. Urinary retention is a known complication, but its description is mostly in the adult literature. Management of urinary catheter (UC) placement and removal is an important consideration in children receiving epidural analgesia. This is a single-center, retrospective observational study which examined UC management in children undergoing lower extremity orthopedic surgery under general anesthesia with or without epidural analgesia from January 2019–June 2021. Of 239 children included, epidural analgesia was used in 57 (23.8%). They were significantly younger and had more co-morbidities. In total, 75 UCs were placed in the OR, 9 in the ward, and 7 re-inserted. UC placement in the epidural group was more common (93% vs. 17%, p < 0.001) and remained longer (3 days vs. 1 day, p = 0.01). Among children without intra-operative UC, ward placement was more common in the epidural cohort (60% vs. 1.6%, p = 0.007). OR UC placement and ward re-insertion were more common in children with neuromuscular disease (61% vs. 22%, p < 0.001), (17% vs. 3%, p = 0.001), respectively. Based on these findings, we hypothesize that it is justifiable to routinely place a UC intra-operatively in children who undergo hip or lower extremity surgery and are treated with epidural analgesia, and caution is advised before early UC removal in orthopedic children with NMD.
Performance analysis of least reliable symbol based ordered successive interference cancelation detection method for uplink NOMA

Nonorthogonal multiple access (NOMA) is one of the key techniques to improve the spectral efficiency required for fifth‐generation (5G) mobile networks. A severe interuser interference is encountered during the detection process in the uplink NOMA scenario, leading to the imperfect successive interference cancelation (SIC), thereby resulting in extreme SIC error propagation. In this work, we propose a novel least‐reliable symbol‐based ordered‐successive interference cancelation (LRS‐OSIC) detection method for uplink NOMA to mitigate the severe effects of SIC error propagation. The bit error rate (BER) performance is presented for different phase‐shift keying (PSK) modulation schemes to better understand the proposed LRS‐OSIC algorithm. Further, detailed comparative analysis with the existing detection techniques for uplink NOMA is illustrated in terms of error rate and computation complexity. The obtained results prove that the proposed LRS‐OSIC detection method for uplink NOMA outperforms other existing techniques and closely matches the best achievable error performance as accomplished by the maximum likelihood (ML) decoder. Moreover, the simulation results are extended for three user scenarios to validate the benefits of the proposed LRS‐OSIC algorithm for more than two user scenarios.
Mindfulness Practice and Job Performance in Social Workers: Mediation Effect of Work Engagement

Despite a rapid increase in the work force over the last decade, the social work labor force is still suffering through high amounts of stress and burnout that could negatively affect work engagement and job performance in China. A potential solution worth exploring, however, is the practice of mindfulness, a concept based on expanding one’s awareness to target focus without judgement. Using 537 social workers from street-level social work service stations in Guangzhou, China, this paper examines the relation between mindfulness practice and job performance, and whether work engagement mediated the relation through the application of the job demand and resources theory. The findings indicate that that mindfulness practice directly increases work engagement (Beta = 0.33) and has an indirect effect on job performance (Beta = 0.21) through its effect on work engagement that fully mediated the relation between mindfulness practice and job performance. In contrast to formal mindful practices (Beta = 0.13), informal mindful practices (Beta = 0.22) encompass a broader impact on employee performance. The findings suggest that mindfulness practice can effectively be used in workspaces to enhance engagement and performance of social workers in China.
Sophorolipids—Bio-Based Antimicrobial Formulating Agents for Applications in Food and Health

Sophorolipids are well-known glycolipid biosurfactants, produced mainly by non-pathogenic yeast species such as Candida bombicola with high yield. Its unique environmental compatibility and high biodegradable properties have made them a focus in the present review for their promising applications in diverse areas. This study aims to examine current research trends of sophorolipids and evaluate their applications in food and health. A literature search was conducted using different research databases including PubMed, ScienceDirect, EBSCOhost, and Wiley Online Library to identify studies on the fundamental mechanisms of sophorolipids and their applications in food and health. Studies have shown that various structural forms of sophorolipids exhibit different biological and physicochemical properties. Sophorolipids represent one of the most attractive biosurfactants in the industry due to their antimicrobial action against both Gram-positive and Gram-negative microorganisms for applications in food and health sectors. In this review, we have provided an overview on the fundamental properties of sophorolipids and detailed analysis of their applications in diverse areas such as food, agriculture, pharmaceutical, cosmetic, anticancer, and antimicrobial activities.
Types of Student Reasoning on Sampling Tasks

As part of a research project on students’ understanding of variability in statistics, 272 students, (84 middle school and 188 secondary school, grades 6 – 12) were surveyed on a series of tasks involving repeated sampling. Students’ reasoning on the tasks predominanly fell into three types: additive, proportional, or distributional, depending on whether their explanations were driven by frequencies, by relative frequencies, or by both expected proportions and spreads. A high percentage of students’ predominant form of reasoning was additive on these tasks. When secondary students were presented with a second series of sampling tasks involving a larger mixture and a larger sample size, they were more likely to predict extreme values than for the smaller mixture and sample size. In order for students to develop their intuition for what to expect in dichotomous sampling experiments, teachers and curriculum developers need to draw explicit attention to the power of proportional reasoning in sampling tasks. Likewise, in order for students to develop their sense of expected variation in a sampling experiment, they need a lot of experience in predicting outcomes, and then comparing their predictions to actual data.
Diverse Effects of Cilostazol on Proprotein Convertase Subtilisin/Kexin Type 9 between Obesity and Non-Obesity

Proprotein convertase subtilisin/kexin type 9 (PCSK9) plays a key role in cholesterol homeostasis. Cilostazol exerts favorable cellular and metabolic effects; however, the effect of cilostazol on the expression of PCSK9 has not been previously reported. Our study aimed to investigate the potential mechanisms of action of cilostazol on the expression of PCSK9 and lipid homeostasis. We evaluated the effects of cilostazol on the expression of PCSK9 in HepG2 cells and evaluated potential molecular mechanisms by measuring signaling molecules in the liver and serum lipid profiles in high-fat diet-induced obese mice and normal chow-fed mice. Cilostazol treatment significantly induced the messenger RNA and protein expression of PCSK9 in HepG2 cells and enhanced PCSK9 promoter activity. Chromatin immunoprecipitation assays confirmed that cilostazol treatment enhanced PCSK9 transcription by binding to peroxisome proliferator-activated receptor-γ (PPARγ) via the PPARγ DNA response element. PPARγ knockdown attenuated the stimulatory effect of cilostazol on PCSK9. In vitro, cilostazol treatment increased PCSK9 expression in vehicle-treated HepG2 cells but decreased PCSK9 expression in palmitic acid-treated HepG2 cells. In vivo, cilostazol treatment increased the serum levels of PCSK9 in normal mice but significantly reduced PCSK9 levels in obese mice. The expressions of PCSK9-relevant microRNAs also showed similar results. Clinical data showed that cilostazol treatment significantly reduced serum PCSK9 levels in patients with obesity. The obesity-dependent effects of cilostazol on PCSK9 expression observed from bench to bedside demonstrates the therapeutic potential of cilostazol in clinical settings.
College Athletes’ Views on Academics: A Qualitative Assessment of Perceptions of Academic Success

The primary purpose of the current study was to give “voice” to college athletes regarding their views on academics. Given their perspectives, means of promoting their academic achievement were suggested. Research describing athletes’ experiences and the impact of socio-emotional stressors on academic success, especially for those not at a Division I school, is needed. Therefore, a qualitative study exploring the academic experiences of college athletes was conducted. Twelve focus groups of college athletes (N = 62) from six teams were held. Results revealed that college athletes are motivated to achieve by external factors and see grades as an external evaluation of performance. Athletes communicate with one another about grades, but this is generally limited to specific assignments rather than semester-long evaluations. Reaching out to academic support staff early in one’s career was reported as helpful, and academic performance could be improved with better communication with professors and more time management skills. The findings provide tools to develop more effective and tailored support programs for college athletes.
Understanding the Role of GLUT2 in Dysglycemia Associated with Fanconi–Bickel Syndrome

Fanconi–Bickel Syndrome (FBS) is a rare disorder of carbohydrate metabolism that is characterized by the accumulation of glycogen mainly in the liver. It is inherited in an autosomal recessive manner due to mutations in the SLC2A2 gene. SLC2A2 encodes for the glucose transporter GLUT2 and is expressed in tissues that are involved in glucose homeostasis. The molecular mechanisms of dysglycemia in FBS are still not clearly understood. In this study, we report two cases of FBS with classical phenotypes of FBS associated with dysglycemia. Genomic DNA was extracted and analyzed by whole-genome and Sanger sequencing, and patient PBMCs were used for molecular analysis. One patient had an exonic SLC2A2 mutation (c.1093C>T in exon 9, R365X), while the other patient had a novel intronic SLC2A2 mutation (c.613-7T>G). Surprisingly, the exonic mutation resulted in the overexpression of dysfunctional GLUT2, resulting in the dysregulated expression of other glucose transporters. The intronic mutation did not affect the coding sequence of GLUT2, its expression, or glucose transport activity. However, it was associated with the expression of miRNAs correlated with type 1 diabetes mellitus, with a particular significant overexpression of hsa-miR-29a-3p implicated in insulin production and secretion. Our findings suggest that SLC2A2 mutations cause dysglycemia in FBS either by a direct effect on GLUT2 expression and/or activity or, indirectly, by the dysregulated expression of miRNAs implicated in glucose homeostasis.
Large-eddy simulation of confined transitional plumes

• A submitted manuscript is the author's version of the article upon submission and before peer-review. There can be important differences between the submitted version and the official published version of record. People interested in the research are advised to contact the author for the final version of the publication, or visit the DOI to the publisher's website. • The final author version and the galley proof are versions of the publication after peer review. • The final published version features the final layout of the paper including the volume, issue and page numbers.
Energy-Efficient Trajectory Design of a Multi-IRS Assisted Portable Access Point

In this article, we propose a framework for energy efficient trajectory design of an unmanned aerial vehicle (UAV)-based portable access point (PAP) deployed to serve a set of ground nodes (GNs). In addition to the PAP and GNs, the system consists of a set of intelligent reflecting surfaces (IRSs) mounted on man-made structures to increase the number of bits transmitted per Joule of energy consumed measured as the global energy efficiency (GEE). The GEE trajectory for the PAP is designed by considering the UAV propulsion energy consumption and the Peukert effect of the PAP battery, which represents an accurate battery discharge profile as a non-linear function of the UAV power consumption profile. The GEE trajectory design problem is solved in two phases: in the first, a path for the PAP and feasible positions for the IRS modules are found using a multi-tier circle packing method, and the required IRS phase shift values are calculated using an alternate optimization method that considers the interdependence between the amplitude and phase responses of an IRS element; in the second phase, the PAP flying velocity and user scheduling are calculated using a novel multi-lap trajectory design algorithm. Numerical evaluations show that: neglecting the Peukert effect overestimates the available flight time of the PAP; after a certain threshold, increasing the battery size reduces the available flight time of the PAP; the presence of IRS modules improves the GEE of the system compared to other baseline scenarios; the multi-lap trajectory saves more energy compared to a single-lap trajectory developed using a combination of sequential convex programming and Dinkelbach algorithm.
IMPROVED DECISION RULES IN THE FELLEGI-SUNTER MODEL OF RECORD LINKAGE

Many applications of the FeUegi-Sunter model use simplifying assumptions and ad hoe modifications to improve matching efficacy. Because of model misspecification, distinctive approaches developed in one application typicaUy cannot be used in other applications and do not always make use of advances in statistical and computational theory. This paper gives an ExpectationMaximization 0EMH) algorithm that constrains the estimates to a convex subregion of the parameter space. The EMH algorithm provides probability estimates that yield better decision rules than unconstrained estimates. The algorithm is related to the Multi-Cycle ExpectationConditional Maximization algorithm (Meng and Rubin 1993) and is deduced via results of Haberman (1977) that hold for large classes of loglinear models.