Miracle-dz/UniFAR-FTUs huggingface dataset:
Speech Audiometrical Results Before and After Reimplantation of Cochlear Implants

Objectives: This study aimed to compare the audiological outcomes of cochlear reimplantation with those of the first cochlear implant (CI). Design: A retrospective analysis was performed on the data of all CI recipients who received the first CI at the age of 8 years or above and who were subsequently reimplanted on the same side. All participants who received their first implant after January 1, 2000, and who were reimplanted before January 1, 2021, were included. CI recipients who were unable to perform an open-set of Flemish monosyllable speech audiometry were excluded. The participants’ clinical files were reviewed in terms of the cause of hearing loss, age at the first and second implantation, device types, the time between the first and second surgery, speech reception scores before and after reimplantation, and the reason for reimplantation. Results: Reimplantation was due to device failure in 19 out of 22 patients, performance decrement in two patients, and medical reasons in one patient. The interval between the first and second CI ranged from 8 to 218 mo. Within-subject analysis showed the speech reception performance with the second CI to be significantly better than that with the first CI at all follow-up time points, with average within-patient gains of 17%, 16%, 12%, and 15% at 3 mo, 9 mo, 3 years, and the highest scores achieved, respectively. After reimplantation, the performance was better than the last results before reimplantation, and this was significant from 9 mo after reimplantation onwards. Three patients (14%) had a performance degradation with the second CI, which was probably owing to (1) difficulties in reimplantation surgery leading to a reduced number of active channels, (2) insufficient experience with the second CI as the reimplantation has been performed recently, and (3) advanced fenestral and retrofenestral otosclerosis. Conclusions: The present study shows that speech reception performance after reimplantation yields faster and better results than the first implant. It takes a couple of months to get better results than those before the reimplantation. Only in a minority of participants, a small deterioration may be observed. It seems that soft failures in the absence of measurable technical abnormalities call for caution with regard to reimplantation.
Electrotactile and Vibrotactile Feedback Enable Similar Performance in Psychometric Tests and Closed-Loop Control

Electro- and vibro-tactile stimulation are commonly employed for feedback in closed-loop human-machine interfacing. Although these feedback systems have been extensively investigated individually, they are rarely objectively compared. In this study, two state-of-the-art stimulation units (concentric electrode and C2-tactor) similar in shape and size were compared in psychometric and online control tests. The just noticeable difference and number of discriminable levels for intensity and frequency modulation were determined across values of carrier frequency and intensity, respectively. Next, subjects performed a compensatory tracking task, in which the feedback encoded the momentary tracking error. In the psychometric tests, intensity modulation outperformed frequency modulation and electrotactile stimulation enabled significantly higher resolution than vibrotactile stimulation, for the same carrier frequency. However, for the best-case settings (eletro-tactile: 100 Hz; vibro-tactile: 200 Hz), the two stimulation modalities were equivalent in the psychometric tests and in the online control tests, where the two stimulation methods resulted in similar correlation and deviation between the target and the generated trajectory. Time delay was slightly but significantly lower for the vibrotactile modality. Overall, the present assessment shows that despite psychometric differences between the two stimulation methods, they enable similar online control performance when parameters are optimally selected for each modality.
Enhanced recognition of emotional images is not affected by post-exposure exercise-induced arousal

Research suggests that aerobic exercise (i.e., exercise aiming to improve cardiovascular fitness) promotes cognition, but the impact on memory specifically, is unclear. There is some evidence to suggest that as little as one session of post-learning exercise benefits memory consolidation. Furthermore, memory may be particularly facilitated by exercise when the individual is emotionally aroused while encoding stimuli. The current study tested whether exercise after exposure to neutral and emotional images improved memory consolidation of the items among university students. Ninety-nine students were randomly instructed to either exercise or not exercise after viewing a set of images that were positive, neutral, and negative in valence, and they were later tested on their memory. Although emotional images were remembered better than non-emotional images, the results suggested that exercise did not influence this effect or enhance consolidation of the items overall. Explanations and implications for these findings are discussed.
Memory recall involves a transient break in excitatory-inhibitory balance

The brain has a remarkable capacity to acquire and store memories that can later be selectively recalled. These processes are supported by the hippocampus which is thought to index memory recall by reinstating information stored across distributed neocortical circuits. However, the mechanism that supports this interaction remains unclear. Here, in humans, we show that recall of a visual cue from a paired associate is accompanied by a transient increase in the ratio between glutamate and GABA in visual cortex. Moreover, these excitatory-inhibitory fluctuations are predicted by activity in the hippocampus. These data suggest the hippocampus gates memory recall by indexing information stored across neocortical circuits using a disinhibitory mechanism.
The SOLAR group program to promote recovery after disaster and trauma-A randomized controlled feasibility trial among German trauma survivors.

INTRODUCTION Many disaster and trauma survivors experience persistent subclinical distress that places them at risk of developing a mental health disorder. This study describes the first European feasibility study of a brief and scalable skills-based intervention targeting persistent subclinical distress following disasters and trauma. METHOD Randomized controlled feasibility study of the Skills fOr Life Adjustment and Resilience (SOLAR) group program. German trauma survivors (N = 30) with subclinical symptoms of depression, anxiety, or posttraumatic stress disorder or functional impairment, but no current mental disorder other than adjustment disorder, were randomized to the SOLAR group program (n = 15) or to a wait-list control group (n = 15). The primary outcome was feasibility, operationalized through eligibility rate, recruitment speed, treatment adherence, dropout rate, and participant satisfaction with the program. Secondary outcomes were psychological distress, symptoms of insomnia, posttraumatic stress disorder, patient-centered outcomes, quality of life, and perceived social support. RESULTS Eligibility rate was 33.6%; recruitment speed was two days per participant; 92.9% completed at least four of five sessions; dropout rate was 10.0%; 92.3% were "very satisfied" with the program. Between-group change scores showed a large effect size for patient-centered outcomes. Medium effect sizes were found for symptoms of insomnia, perceived social support, and quality of life. Small effects were identified for reductions in distress and functional impairment. DISCUSSION The application of the SOLAR group program within a randomized controlled trial was feasible. Its efficacy should be further tested in a larger trial. (PsycInfo Database Record (c) 2021 APA, all rights reserved).
The Revolution Will Be Hard to Evaluate: How Co-Occurring Policy Changes Affect Research on the Health Effects of Social Policies

Abstract Extensive empirical health research leverages variation in the timing and location of policy changes as quasi-experiments. Multiple social policies may be adopted simultaneously in the same locations, creating co-occurrence that must be addressed analytically for valid inferences. The pervasiveness and consequences of co-occurring policies have received limited attention. We analyzed a systematic sample of 13 social policy databases covering diverse domains including poverty, paid family leave, and tobacco use. We quantified policy co-occurrence in each database as the fraction of variation in each policy measure across different jurisdictions and times that could be explained by covariation with other policies. We used simulations to estimate the ratio of the variance of effect estimates under the observed policy co-occurrence to variance if policies were independent. Policy co-occurrence ranged from very high for state-level cannabis policies to low for country-level sexual minority-rights policies. For 65% of policies, greater than 90% of the place-time variation was explained by other policies. Policy co-occurrence increased the variance of effect estimates by a median of 57-fold. Co-occurring policies are common and pose a major methodological challenge to rigorously evaluating health effects of individual social policies. When uncontrolled, co-occurring policies confound one another, and when controlled, resulting positivity violations may substantially inflate the variance of estimated effects. Tools to enhance validity and precision for evaluating co-occurring policies are needed.
Cellular Origins of EGFR‐Driven Lung Cancer Cells Determine Sensitivity to Therapy

Targeting the epidermal growth factor receptor (EGFR) with tyrosine kinase inhibitors (TKIs) is one of the major precision medicine treatment options for lung adenocarcinoma. Due to common development of drug resistance to first‐ and second‐generation TKIs, third‐generation inhibitors, including osimertinib and rociletinib, have been developed. A model of EGFR‐driven lung cancer and a method to develop tumors of distinct epigenetic states through 3D organotypic cultures are described here. It is discovered that activation of the EGFR T790M/L858R mutation in lung epithelial cells can drive lung cancers with alveolar or bronchiolar features, which can originate from alveolar type 2 (AT2) cells or bronchioalveolar stem cells, but not basal cells or club cells of the trachea. It is also demonstrated that these clones are able to retain their epigenetic differences through passaging orthotopically in mice and crucially that they have distinct drug vulnerabilities. This work serves as a blueprint for exploring how epigenetics can be used to stratify patients for precision medicine decisions.
Determinants of Low Birth Weight Among Women Who Gave Birth at Public Health Facilities in North Shewa Zone: Unmatched Case-Control Study

Globally, more than 20 million newborns are born with low birth weight (LBW) every year. Most of the LBW occurs in low- and middle-income countries. It is the most critical risk of neonate mortality. Therefore, this study aims to identify determinants of low birth weight among women who gave birth in public health facilities in the North Shewa zone. Institutional-based unmatched case–control study was conducted from February to June 2020 to select 180 cases and 380 controls. Interviewer-administered questionnaire was used to collect data. Data were entered through EPI Info and exported to Statistical Package for Social Science (SPSS) for analysis. Text, percentage and tables were used to present data. Bivariate and multivariate logistic regression analyses were performed to see the association and adjusted odds ratios with 95% confidence interval (CI), and P-value < . 05 was considered to declare statistical significance. Lack of nutritional counseling (adjusted odds ratio [AOR] = 2.14; 95% CI = [1.13, 4.04]), unable to take iron-folate supplement (AOR = 2.3.78; 95% CI = [2.1, 6.85]), insufficient additional meal in take (AOR = 6.93; 95% CI = [3.92, 12.26]), restriction of foods (AOR=2.29; 95% CI =[1.81, 4.09]), maternal mid upper arm circumference (MUAC) < 23 cm (AOR=2.85; 95% CI = [ 1.68, 4.85]), maternal height ≤155 cm (AOR=3.58; 95% CI = [1.92, 6.7]), anemia (AOR = 2.34; 95% CI = [1.21, 4.53]), pregnancy-related complications (AOR=3.39; 95% CI = [2.02, 5.68]), and alcohol drinking during pregnancy (AOR = 2.25; 95% CI = [1.24, 4.08]) were significantly associated with LBW. Nutritional counseling, iron-folate supplementation, additional meal intake, restriction of some foods in pregnancy, MUAC of the mother, maternal stature, maternal anemia status, pregnancy-related complications, and a history of alcohol drinking during pregnancy were identified as determinants of low birth weight. The intervention-targeted nutritional counseling, early detection and treatment of anemia, and behavioral change communication to pregnant women are mandatory.
Monetary incentives increase COVID-19 vaccinations

Description Valuing vaccination Using money as a motivation for the public to get vaccinated is controversial and has had mixed results in studies, few of which have been randomized trials. To test the effect of money as an incentive to obtain a vaccine, Campos-Mercade et al. set up a study in Sweden in 2021, when various age groups were first made eligible to receive the severe acute respiratory coronavirus 2 vaccine (see the Perspective by Jecker). The effect of a small cash reward, around US $24, was compared with the effect of several behavioral nudges. The outcome of this preregistered, randomized clinical trial was that money had the power to increase participation by about 4 percentage points. Nudging and reminding didn’t seem to be deleterious and even had a small positive effect. Of course, the question of whether it is ethical to pay people to be vaccinated like this needs to be addressed. —CA In Sweden, monetary incentives of US $24 increased vaccination rates from approximately 72% to approximately 76%. The stalling of COVID-19 vaccination rates threatens public health. To increase vaccination rates, governments across the world are considering the use of monetary incentives. Here we present evidence about the effect of guaranteed payments on COVID-19 vaccination uptake. We ran a large preregistered randomized controlled trial (with 8286 participants) in Sweden and linked the data to population-wide administrative vaccination records. We found that modest monetary payments of 24 US dollars (200 Swedish kronor) increased vaccination rates by 4.2 percentage points (P = 0.005), from a baseline rate of 71.6%. By contrast, behavioral nudges increased stated intentions to become vaccinated but had only small and not statistically significant impacts on vaccination rates. The results highlight the potential of modest monetary incentives to raise vaccination rates.
Unsupervised domain adaptation model for lesion detection in retinal OCT images

Background and objective. Optical coherence tomography (OCT) is one of the most used retinal imaging modalities in the clinic as it can provide high-resolution anatomical images. The huge number of OCT images has significantly advanced the development of deep learning methods for automatic lesion detection to ease the doctor’s workload. However, it has been frequently revealed that the deep neural network model has difficulty handling the domain discrepancies, which widely exist in medical images captured from different devices. Many works have been proposed to solve the domain shift issue in deep learning tasks such as disease classification and lesion segmentation, but few works focused on lesion detection, especially for OCT images. Methods. In this work, we proposed a faster-RCNN based, unsupervised domain adaptation model to address the lesion detection task in cross-device retinal OCT images. The domain shift is minimized by reducing the image-level shift and instance-level shift at the same time. We combined a domain classifier with a Wasserstein distance critic to align the shifts at each level. Results. The model was tested on two sets of OCT image data captured from different devices, obtained an average accuracy improvement of more than 8% over the method without domain adaptation, and outperformed other comparable domain adaptation methods. Conclusion. The results demonstrate the proposed model is more effective in reducing the domain shift than advanced methods.
Antioxidant Activity of Flaxseed (Linum usitatissimum L.) shell and Analysis of Its Polyphenol Contents by LC-MS/MS

Flaxseed (Linum usitatissimum L.) is important source of oil and protein for industrial, pharmaceutical, and nutritional applications. In order to estimate the effects of lyophilized aqueous extract of flaxseed shell (AEF) and evaporated ethanolic extract of flaxseed shell (EEF), we studied their DPPH, ABTS, DMPD and O2 •scavenging effects. Total antioxidant activity by ferric thiocyanate method, Fe 3+ , Cu 2+ and [Fe 3+ (TPTZ)2] 3+ reducing ability, and Fe 2+ chelating activity. Also, α-tocopherol, BHA, trolox, and BHT were used as positive controls. The results clearly AEF and EEF demonstrated effective antioxidant activity. The quantity of p-hydroxybenzoic, vanillin, p-coumaric acid, ascorbic acid, ferulic acid, and ellagic acid were investigated by LC-MS/MS. The present study will introduce a novelty for further studies on the antioxidant effects of AEF and
Risk Factors Associated With Pressure Ulcers in Patients With Traumatic Brain Injury Admitted to the Intensive Care Unit

Pressure injuries (PIs) are one of the most important and frequent complications in patients admitted to the intensive care unit (ICU) or those with traumatic brain injury (TBI). The purpose of this study was to determine the incidence and risk factors of PIs in patients with TBI admitted to the ICU. In this retrospective study, the medical records of 237 patients with TBI admitted to the trauma ICU of a university hospital were examined. Demographic, trauma-related, and treatment-related characteristics of all the patients were evaluated from their records. The incidence of PIs was 13.9%, while the main risk factors were a higher injury severity score, use of mechanical ventilation, vasopressor infusion, lower Braden Scale score, fever, and period of enteral feeding. This study advances the nursing practice in the ICU by predicting the development of PIs and their characteristics in patients with TBI.
Trivalent nucleoside-modified mRNA vaccine yields durable memory B cell protection against genital herpes in preclinical models.

Nucleoside-modified mRNA vaccines have gained global attention because of COVID-19. We evaluated a similar vaccine approach for preventing a chronic latent genital infection rather than an acute respiratory infection. We used animal models to compare an HSV-2 trivalent nucleoside-modified mRNA vaccine with the same antigens prepared as proteins with an emphasis on antigen-specific memory B cell responses and immune correlates of protection. In guinea pigs, serum neutralizing antibody titers were higher at one month and declined far less by eight months in mRNA- than protein-immunized animals. Both vaccines protected against death and genital lesions when infected one month after immunization; however, protection was more durable in the mRNA than protein group when infected after eight months, an interval representing >15% of the animal's lifespan. Serum and vaginal neutralizing antibody titers correlated with protection against infection as measured by genital lesions and vaginal virus titers two days post infection. In mice, the mRNA vaccine generated more antigen-specific memory B cells than the protein vaccine at early times post immunization that persisted for up to one year. High neutralizing titers and robust B cell immune memory likely explain the more durable protection by the HSV-2 mRNA vaccine.
Health Care Use and Outcomes in Assisted Living Communities: Race, Ethnicity, and Dual Eligibility

Assisted Living (AL) has become an important residential long-term care option in the United States, yet very little is known about the nature and quality of care received in this setting by racial/ethnic minorities or residents dually eligible for Medicare and Medicaid. Using calendar year 2018 Medicare data, we identified 255,564 fee-for-service Medicare beneficiaries age 55+ who resided in 24,108 ALs across the United States. We fit several logistic regression models with individual-level covariates and AL-level fixed effects, to examine the association between race/ethnicity and dual status with inpatient hospital admission, 30-day readmission, emergency room use, and nursing home placement. Significant variations in these measures were found both within and across ALs for racial/ethnic minority and dual residents. Our results suggest that disparities in outcomes are most significant by dual eligibility status rather than by race/ethnicity alone. These findings provide important implications for providers, policy makers, and researchers.
Redundant laboratory testing on referral from general practice to the outpatient clinic: a post-hoc analysis

Background Inappropriately repeated laboratory testing is a commonly occurring problem. However, this has not been studied extensively in the outpatient clinic after referral by GPs. Aim The aim of this study was to investigate how often laboratory tests ordered by the GP were repeated on referral to the outpatient clinic, and how many of the normal test results remained normal on repetition. Design & setting This is a post-hoc analysis of a study on laboratory testing strategies in patients newly referred to the outpatient clinic between April 2015 and April 2017. Method All patients who had a referral letter including laboratory test results ordered by the GP were included. These results were compared with the laboratory test results ordered in the outpatient clinic. Results Data were available for 295 patients, 191 of which had post-visit testing done. In this group, 56% of tests ordered by the GP were repeated. Tests with abnormal results were repeated more frequently than tests with normal results (65% versus 53%; P<0.001). A longer test interval was associated with slightly smaller odds of tests being repeated (odds ratio [OR] 0.97, 95% confidence interval [CI] = 0.95 to 0.99; P = 0.003). Of the tests with normal test results that were repeated, 90% remained normal. This was independent of testing interval or testing strategy. Conclusion Laboratory tests ordered by the GP are commonly repeated on referral to the outpatient clinic. The number of test results remaining normal on repetition suggests a high level of redundancy in laboratory test repetition.