Miracle-dz/UniFAR-FTUs huggingface dataset:
Longitudinal geo-referenced field evidence for the heightened BMI responsiveness of obese women to price discounts on carbonated soft drinks

There is increasing interest in the effect that food environments may have on obesity, particularly through mechanisms related to the marketing and consumption of calorie-dense, nutrient-poor foods and sugary beverages. Price promotions, such as temporary price discounts, have been particularly effective in the marketing of carbonated soft drinks (CSDs) among consumers. Research has also suggested that the purchasing behavior of consumer groups may be differentially sensitive to price discounts on CSDs, with obese women particularly sensitive. In addition, the intensity of price discount in a person’s food environment may also vary across geography and over time. This study examines whether the weight change of obese women, compared to overweight or normal BMI women, is more sensitive to the intensity of price discounts on CSDs in the food environment. This study used longitudinal survey data from 1622 women in the Montreal Neighborhood Networks and Health Aging (MoNNET-HA) Panel. Women were asked to report their height and weight in 2008, 2010 and 2013 in order to calculate women’s BMI in 2008 and their change of weight between 2008 and 2013. Women’s exposure to an unhealthy food environment was based on the frequency in which their neighborhood food stores placed price discounts on CSDs in 2008. The price discount frequency on CSDs within women’s neighborhoods was calculated from Nielsen point-of sales transaction data in 2008 and geocoded to participant’s forward sortation area. The prevalence of obesity and overweight among MoNNET-HA female participants was 18.3% in 2008, 19.9% in 2010 and 20.7% in 2013 respectively. Results showed that among obese women, exposure to unhealthy food environments was associated with a 3.25 kilogram (SE = 1.35, p-value = 0.02) weight gain over the five-year study period. Exposure to price discounts on CSDs may disproportionately affect and reinforce weight gain in women who are already obese.
Postoperative Apnea in a Neonate Following an Epidural Bolus Dose Through a High Thoracic Epidural Catheter

Regional anesthesia is being used more frequently in the practice of pediatric anesthesia including neonates and infants. While generally safe and effective, adverse effects may occur related to catheter placement or its subsequent use. We present the rare occurrence of high motor blockade with apnea following the administration of a bolus dose of the local anesthetic agent, 2-chloroprocaine, into the thoracic epidural catheter of a 4-week-old, 2.2-kg former premature neonate. The patient had an epidural catheter that had been threaded from the caudal space to the thoracic level to provide analgesia following an abdominal surgical procedure. Subsequent investigation with a standard chest radiograph revealed a higher than intended placement of the epidural catheter (T4 instead of T8-10) which resulted in a transient high motor blockade with apnea. The epidural infusion was discontinued and assisted ventilation was provided by bag-valve-mask ventilation. Immediately, the heart rate and oxygen saturation returned to baseline values, and within 5 min the patient became more active, spontaneous ventilation resumed, and a strong cry was noted. The epidural catheter was removed and the remainder of the postoperative course was unremarkable. Adverse effects of epidural anesthesia in neonates are discussed and options for identifying the correct placement of a thoracic epidural catheter are reviewed.
WGS- versus ORF5-Based Typing of PRRSV: A Belgian Case Study

Porcine reproductive and respiratory syndrome virus (PRRSV) is the causative agent of one of the most widespread and economically devastating diseases in the swine industry. Typing circulating PRRSV strains by means of sequencing is crucial for developing adequate control strategies. Most genetic studies only target the highly variable open reading frame (ORF) 5, for which an extensive database is available. In this study, we performed whole-genome sequencing (WGS) on a collection of 124 PRRSV-1 positive serum samples that were collected over a 5-year period (2015–2019) in Belgium. Our results show that (nearly) complete PRRSV genomes can be obtained directly from serum samples with a high success rate. Analysis of the coding regions confirmed the exceptionally high genetic diversity, even among Belgian PRRSV-1 strains. To gain more insight into the added value of WGS, we performed phylogenetic cluster analyses on separate ORF datasets as well as on a single, concatenated dataset (CDS) containing all ORFs. A comparison between the CDS and ORF clustering schemes revealed numerous discrepancies. To explain these differences, we performed a large-scale recombination analysis, which allowed us to identify a large number of potential recombination events that were scattered across the genome. As PRRSV does not contain typical recombination hot-spots, typing PRRSV strains based on a single ORF is not recommended. Although the typing accuracy can be improved by including multiple regions, our results show that the full genetic diversity among PRRSV strains can only be captured by analysing (nearly) complete genomes. Finally, we also identified several vaccine-derived recombinant strains, which once more raises the question of the safety of these vaccines.
How suspense and surprise enhance subsequent memory: the case of the 2016 United States Presidential Election

ABSTRACT We examined whether the retroactive enhancement effect – i.e., improved memory accuracy for event details occurring before a surprising moment – would be present in participants’ memory for details in their private lives following a surprising and suspenseful public event. To equate event type across participants, we selected when they first learned the outcome of the 2016 US Presidential Election. Participants self-divided into those who viewed the outcome as positive, negative, or neutral, while we experimentally divided them into those whose memory was assessed 6 or 12 months post-election. We assessed their accuracy for details surrounding the election and their phenomenological experience of learning the outcome, including emotional tension, our operationalisation of suspense. We found participants’ memory characteristics were strongly related to their level of tension and shock, irrespective of valence. We also observed uniformly high accuracy regarding details about the weather participants experienced in their ZIP codes on election day. While these results intimated about the presence of retroactive enhancement, Experiment 2 examined the effect more directly by comparing participants’ memory for the 2016 Election with two other politically-relevant events that provoked less tense reactions. The results revealed retroactive enhancement is dependent upon experiencing a surprising moment amidst a suspenseful event.
The behavior of very high current density power MOSFETs

A new and complete description of the current carrying mechanisms of a power MOSFET is presented. This is aimed at clarifying the relatively complex behavior of such devices operating at high current densities, with particular reference to the drain-voltage dependence associated with quasi-saturation. This physical insight provides an elegant method of comparing the relative merits of the DMOS and UMOS structures.
Hypoxia responsive nano-drug delivery system based on angelica polysaccharide for liver cancer therapy

Abstract Based on the tumor hypoxic microenvironment and the new programmed cell death mode of combined ferroptosis, an angelica polysaccharide-based nanocarrier material was synthesized. The polymer contains hydrophilic angelica polysaccharide (ASP) that is linked by azobenzene (AZO) linker with ferrocene (Fc), and then the side chain was covalently modified with arachidonic acid (AA). It was postulated that the polymer micelles could work as an instinctive liver targeting drug delivery carrier, owing to the existence of ASP with liver targeting. Moreover, the aim was to engineer hypoxia-responsive polymer micelles which was modified by AA, for selective enhancement of ferroptosis in solid tumor, via diminishing glutathione (GSH) under hypoxia. Finally, we synthesized the amphiphilic polymer micelles AA/ASP-AZO-Fc (AAAF) by self-assembling. The structure of AAAF was confirmed by 1H-NMR and FT-IR. Then, we exemplified the hydrophobic medication curcumin into polymer micelles AAAF@Cur, which has smooth and regular spheres. In vitro release test affirmed that AAAF@Cur can achieve hypoxia response to drug release. In addition, a series of cell experiments confirmed that hypoxia could enhance cell uptake and effectively improve the proliferation inhibitory activity of HepG2 cells. In conclusion, AAAF, as an effective cell carrier, is expected to develop in sensitizing ferroptosis and anti-tumor.
The Influence of Masonry Infill Walls in the Framework of the Performance-Based Design

In this article, a performance-based seismic design (PBD) methodology is proposed for the design of reinforced concrete buildings, taking into account the influence of infill walls. Two variants of the PBD framework are examined: The first is based on the non-linear static analysis procedure (NSP) while the second relies on the non-linear dynamic analysis procedure (NDP). Both design approaches are compared in the context of structural optimization with reference to the best possible design achieved for each case examined. Life-cycle cost analysis is considered a reliable tool for assessing the performance of structural systems and it is employed in this study for assessing the optimum designs obtained. The optimization part of the problem is performed with an Evolutionary Algorithm while three performance objectives are implemented in all formulations of the design procedures. The two most important findings can be summarized as follows: (i) if structural realization follows the design assumptions, then total expected life-cycle cost of the three type of structures, bare, fully infilled and open ground story, is almost the same and (ii) if an open ground story building is designed as bare or as fully infilled frame, real performance will be much worse than anticipated at the design stage.
From urban waste to urban farmers: Can we close the agriculture loop within the city bounds?

As urbanisation intensifies in Brazilian cities, life quality in urban centres becomes a challenge for policymakers, and transitioning urban systems to sustainability is required. Circular economy concepts may contribute to face them, especially those owing to municipal solid waste (MSW) management. Curitiba, a Brazilian municipality known for its innovative initiatives towards sustainability. Despite a long tradition in recycling inert waste, MSW system struggles to promote composting even considering a decade in force national law. Decentralised composting through the Urban Agriculture Program (UAP) is the city’s strategy to tackle this struggle. This strategy faces difficulties as, even if urban agriculture facilities seem to be a promising context, closing the agricultural loop within the city bounds was not possible in the 24 urban farmers communities trained in composting techniques. The literature has shown difficulties in government experiments to promote practices in the long run and several experiences in Brazil are already described. This study reveals cultural barriers that influence adoption of domestic composting, by following a secondary data review on past experiences with interviewing and observing participatively urban farms communities. From the fieldwork, cultural perspectives from four different relevant actor roles in the UAP were elaborated and conflicts between them revealed cultural barriers hindering composting practices adoption. Recommendations based on these barriers argue for bottom-up approaches for transition experiments and recognising the sense material and technical support makes to practitioners.
SOME ISSUES OF LIFE ACTIVITIES OF POPULATION IN THE CHORNOBYL EXCLUSION ZONE IN UKRAINE.

BACKGROUND Radiation accidents at the Chornobyl Nuclear Power Plant (USSR, 1986) and Fukushima-1 (Japan,2011) have shown that global environmental contamination is an intervention in normal human life making nega-tive effect on population health. These accidents highlighted a number of statutory and regulatory both with me-dical and social problems for individuals, who returned voluntarily for permanent residence in the ChornobylExclusion Zone i.e. a radiation-hazardous area (they are named the «self-settlers»). OBJECTIVE generalization of experience in the settlement of normative-legal, ecological-dosimetric and medico-social life issues of population living in the Chornobyl NPP (ChNPP) Exclusion Zone («self-settlers»). OBJECT AND METHODS The chosen problem is complex, necessitating the generalization of radiation-hygienic, med-ical-biological, socio-economic, demographic and sociological research results obtained by the national and foreignauthors. A set of theoretical research and analysis of empirical data methods on the principles of interdisciplinaryinteraction was used; the systematic, legal, economic, medical-biological, demographic and retrospective-dosimet-ric approaches of research were applied. RESULTS It was shown that a part of population refused to evacuate or had returned for permanent residence to theradiation-hazardous lands after the ChNPP accident. In 1986-2009 the number of «self-settlers» ranged from 150to 2,000 in different years. In 2021 - the 101 people. Those were mainly people of working age, mostly females, single people or widows/widowers. Рrevious medical and dosimetric studies have shown that long-term residence inthe Exclusion Zone affects physical and mental health of «self-settlers» and causes atypical aging, includinginvolvement of the central nervous system. According to calculations, the average effective total radiation doseaccumulated by «self-settlers» for the first 3 years was 30 % of dose for the entire post-accident period, and thedose accumulated over 20 years was 54 % of the dose accumulated over 35 years. But the effective radiation dosesaccumulated in different periods after the accident differ significantly in residents of different Exclusion Zone settlements. This information needs further study in terms of the «radiation dose - health status» dependence. CONCLUSIONS The effective radiation doses accumulated in different periods after the accident differ significantlyin the residents of different Exclusion Zone settlements. Тhe average effective total radiation dose accumulated by«self-settlers» for the first 3 years was 30 % of the dose for the entire post-accident period, and the dose accumulated over 20 years was 54 % of the dose accumulated over 35 years.
Effect of Perioperative Patient Education via Animated Videos in Patients Undergoing Head and Neck Surgery: A Randomized Clinical Trial.

Importance Patient education and engagement is a pivotal component of surgical recovery. Ensuring proper patient education involves a thorough understanding of one's diagnosis and recovery plan, while reducing language and learning barriers to help patients make informed decisions and improve their hospital experience. Objective To assess whether using an animated surgical guide will help patients who are undergoing head and neck surgery feel more satisfied with their surgery and recovery process. Design, Setting, and Participants A randomized clinical trial was conducted between January and August 2020 at a single tertiary care academic center in Montreal, Canada. A consecutive sample of individuals who were undergoing any of the following surgical procedures was recruited: head and neck cancer resection with or without reconstruction, parotidectomy, thyroidectomy, parathyroidectomy, laryngectomy, or transoral robotic resection. The treating team was masked to group allocation, while study participants in the nonintervention group were unaware of the multimedia platform to avoid introducing bias in their survey responses. Interventions Patients were randomly allocated to either the treatment arm, in which they obtained access to a multimedia patient education platform, or the control arm, in which they received traditional patient education methods via clinical visits. Main Outcomes and Measures Primary analysis compared patient satisfaction scores on the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire INFO 25, a validated questionnaire on the perceived quality of information received by patients with cancer (possible scores ranging from 20 to 80). Results A total of 100 patients (50 in each arm; 63 women [63%]; 6 African American [6%, 12 Hispanic/Latino [12%], 11 Middle Eastern [11%], and 78 White [78%] individuals) completed the preintervention and postintervention questionnaires. In those who received access to the patient education platform, there was an 11.3-point (Cohen d = 1.02; control group score, 61.1 of 80; treatment group score, 72.4 of 80) difference of greater postoperative satisfaction scores at 1 month. While both groups felt that they received an adequate amount of information concerning their disease process, patients in the treatment arm had significantly better satisfaction with information concerning their medical tests, treatments, and other services. Conclusions and Relevance This randomized clinical trial of patients undergoing head and neck cancer treatment demonstrates that multimedia patient education platforms may enhance current traditional methods, providing complementary information on patients' treatment plans and recovery process, mental health, family life, and supplementary services. Further research is currently underway to confirm whether this platform will lead to decreased hospital stay, shorter complication rates, and long-term effects. Trial Registration ClinicalTrials.gov Identifier: NCT04048538.
Cardiovascular and haematological events post COVID‐19 vaccination: A systematic review

Since COVID‐19 took a strong hold around the globe causing considerable morbidity and mortality, a lot of effort was dedicated to manufacturing effective vaccines against SARS‐CoV‐2. Many questions have since been raised surrounding the safety of the vaccines, and a lot of media attention to certain side effects. This caused a state of vaccine hesitancy that may prove problematic in the global effort to control the virus. This review was undertaken with the aim of putting together all the reported cardiovascular and haematological events post COVID‐19 vaccination in published literature and to suggest possible mechanisms to explain these rare phenomena.
Racial and Ethnic Disparities in Primary Cleft Lip and Cleft Palate Repair

Objective To examine the impact of race/ethnicity on timing and postoperative outcomes of primary cleft lip (CL) and cleft palate (CP) repair. Design Cross-sectional analysis of the National Surgical Quality Improvement Program Pediatric (NSQIP-P) database from 2013 to 2018. Patients and main outcome measures Patients under 2 years of age who underwent primary CL or CP repair were identified in the NSQIP-P. Outcomes were the timing of surgery and 30-day readmission and reoperation rates stratified by race and ethnicity. Results In total, 6021 children underwent CL and 6938 underwent CP repair. Adjusted rates of CL repair over time were 10% lower in Hispanic children (95%CI: 0.84–0.96) and 38% lower for Asian children (95%CI: 0.55–0.70) compared with White infants. CP repair rates over time were 13% lower in Black (95%CI: 0.79–0.95), 17% lower in Hispanic (95%CI: 0.77–0.89), and 53% lower in Asian children (95%CI: 0.43–0.53) than in White infants. Asian patients had the highest rates of delayed surgical repair, with 19.3% not meeting American Cleft Palate-Craniofacial Association (ACPA) guidelines for CL (P < .001) and 28.2% for CP repair (P< .001). Black and Hispanic children had 80% higher odds of readmission following primary CL repair (95%CI: 1.16–2.83 and 95%CI: 1.27–2.61, respectively). Conclusions This study of a national database identified several racial/ethnic disparities in primary CL and CP, with reduced receipt of cleft repair over time for non-White children. Asian patients were significantly more likely to have delayed cleft repair per ACPA guidelines. These findings underscore the need to better understand disparities in cleft repair timing and postoperative outcomes.
Analysis of craft workers' and foremen's perceptions of the factors affecting construction labour productivity

Extensive studies have been conducted to examine the factors affecting construction productivity, but efforts have rarely been made to obtain craft workers' input. A survey was administered to 1996 craft workers throughout the US to quantify the workforce's perspective of construction labour productivity. Specifically, the survey measured the impact of 83 productivity factors, which had been identified through 18 focus group sessions with craft workers and their immediate supervisors on jobsites located throughout the US. Craft workers provide detailed insight into the factors affecting their daily productivity, and most of the adversarial factors affecting construction labour productivity can be addressed by jobsite management teams. The major findings indicated that craft workers and foremen share a general perception of the factors impacting on construction productivity; however, differences do exist. Specifically, foremen reported factors related to project management and engineering drawings having a more severe impact on their productivity compared to craft workers, and craft workers reported factors related to construction materials as having a more severe impact.
Environmental Factors as Diabetic Mediators-A Mechanistic Approach.

Despite substantial investment in research and treatment options, diabetes mellitus remains a pressing public health concern with potential epidemic proportions globally. There are reports that by the end of 2040, 642 million people will be suffering from diabetes. Also, according to an estimation, 1.6 million deaths were caused directly by diabetes in 2016. Diabetes is a metabolic disorder characterized by impaired glucose regulation in the body due to the destruction of pancreatic β-cells or insulin resistance. Genetic propensity, unhealthy and imbalanced diet, obesity and increasing urbanization are the common risk factors for diabetes. Besides this, it has been reported that environmental pollutants like organic pesticides, heavy metals, and air pollutants act as strong predisposing factors for diabetes owing to their highly bio-accumulative nature. These pollutants disturb glucose homeostasis either by up-regulating or down-regulating the expression of diabetic marker genes like insulin (INS), glucokinase (GCK). Unfortunately, the molecular mechanism about the role of pollutants in causing diabetes is not very clear. This mechanistic review provides evidence of different environmental determinants including persistent organic pollutants (POPs), air pollutants, toxic metals, etc. in inducing diabetes and proposes a framework for the possible mechanisms involved. It also illuminates the current status and future challenges which will not only broaden our understanding but can also be a reasonable platform for further investigation.