Miracle-dz/UniFAR-FTUs huggingface dataset:
Effect of a single dose of the interleukin-6 receptor antagonist tocilizumab on inﬂammation and troponin T release in patients with non-ST-elevation myocardial infarction: a double-blind, randomized, placebo-controlled phase 2 trial †

¼ 58), administered as a single dose prior to coronary angiography. High sensitivity (hs) C-reactive protein and hsTnT were measured at seven consecutive timepoints between Days 1 and 3. The area under the curve (AUC) for high-sensitivity C-reactive protein was the primary endpoint. The median AUC for high-sensitivity C-reactive protein during hospitalization was 2.1 times higher in the placebo than in the tocilizumab group (4.2 vs. 2.0 mg/L/h, P , 0.001). Also, the median AUC for hsTnT during hospitalization was 1.5 times higher in the placebo group compared with the tocilizumab group (234 vs. 159 ng/L/h, P ¼ 0.007). The differences between the two treatment groups were observed mainly in (i) patients included ≤ 2 days from symptom onset and (ii) patients treated with percutaneous coronary intervention (PCI). No safety issues in the tocilizumab group were detected during 6 months of follow-up. A 48-year-old man with idiopathic dilated inﬂammation, the
Growth, Digestive Tract and Muscle Weights in Slow-Growing Broiler is not Affected by a Blend of Branched-Chain Amino Acids Injected into Different Sites of Egg

One hundred-fifty fertile eggs from 30-week-old Ross x Rhode Island Red (RIR) breeders as a factorial arrangement of 3 injection site (amnion, yolk sac or albumin) and 2 levels of BCAA (Control and BCAA, 0.2%) were arranged into 6 groups with 3 replicates. The solutions used in ovo feeding were aseptically prepared to contain 0% (C) or 0.2% BCAA (mixed within ratio of 2 L-leucine: 1 L-valine: 1 L- isoleucine) in 0.5% saline. At 18 d of incubation 1 ml of in ovo feeding solution was injected into the amnion (A), yolk sac (Y) or albumin (AL) of egg. Hence, there were six nutrition treatments; AC (n = 25), ABCAA (n = 25), YC (n = 25), YBCAA (n = 25), ALC (n = 25) and ALBCAA (n = 25). Upon hatch obtained birds were fed on standard broiler diets until slaughter (8 weeks of age). The YC had lower gizzard weight (P = 0.023) compared to other treatments. The interaction effect of factors on the gizzard weight was found significant (P < 0.025). The in ovo BCAA injection increased the gizzard weight of AL chicks while decreased that of A and Y birds. The crude fat content of thigh meat from Y birds was lower than those of A and AL broilers (P = 0.029). However, growth performance, muscles weights, digestive tract weight and length and abdominal fat, hearth, liver, weights are not affected by factors. The role of in ovo BCAA injection in slow-growing broiler needs further research.
Energy and Exergy Analysis of Mount Salak Geothermal Power Plant Unit 1-2-3

Excellence in skilled operation is vital for the efficiency of geothermal power plants. Mount Salak geothermal power plant unit 1-2-3 has consistently produced no less than 180 MWe to the Java-Bali grid since its first commercial operation in 1994, with an equivalent availability factor (EAF) average of 96%. Owing to this long operation period, power plant efficiency must be improved for the sustainable production of electricity. In this study, energy and exergy analysis has been undertaken to ascertain the amount of energy that is used in the power plant’s current condition, and to determine the plant’s overall system losses. Research was carried out by collecting data relating to temperature, pressure, and mass flow rate. Data were analyzed using the control volume to assess the thermal and mass balance and ascertain the value of exergy. Analysis was conducted theoretically and compared with results calculated by Engineering Equation Solver (EES) software. The results showed that from 1069,90 MWe in steam energy entering the system, the total amount of exergy was 302.42 MWe. Mount Salak geothermal power plant unit 1-2-3 had an overall first law efficiency of 16.75% and an overall second law efficiency of 59.27%. The greatest losses  27.84% of the total exergy  were in the condensers. This was caused by the quality of cooling water entering condensers, which was in turn a result of cooling tower performance. Results suggest that turbine unit 1 should be investigated further to determine causes of
Outer membrane protein change combined with co-existing TEM-1 and SHV-1 (cid:2) -lactamases lead to false identiﬁcation of ESBL-producing Klebsiella pneumoniae

Nine isolates of Klebsiella pneumoniae , obtained from one colonized and eight bacteraemic patients on a paediatric ward, were shown to be identical by PFGE, indicating an outbreak. Screening for extended-spectrum (cid:2) -lactamase (ESBL) production using the double-disc synergy test, Etest for ESBLs and agar diffusion tests indicated ESBL production. The isolates showed reduced susceptibility to cefotaxime but not to other third-generation cephalosporins. Molecular studies revealed production of TEM-1 and SHV-1 but no ESBLs were identiﬁed. Deﬁciency in expression of an outer membrane protein (OmpK35) was also observed. These observations led us to postulate that the extremely low level of OmpK35 expression and the co-existence of TEM-1 and SHV-1 resulted in an increased MIC of cefotaxime and the false designation of the isolates as ESBL producers. All the infected infants were treated with either third-generation cephalosporins alone or multiple antibiotics including a third-generation cephalosporin, and recovered and were discharged without sequelae.
A general decision theory for Huber’s (cid:2) -contamination model

: Today’s data pose unprecedented challenges to statisticians. It may be incomplete, corrupted or exposed to some unknown source of contamination. We need new methods and theories to grapple with these challenges. Robust estimation is one of the revived ﬁelds with potential to accommodate such complexity and glean useful information from modern datasets. Following our recent work on high dimensional robust covariance matrix estimation, we establish a general decision theory for robust statis- tics under Huber’s (cid:2) -contamination model. We propose a solution using Scheﬀ´e estimate to a robust two-point testing problem that leads to the construction of robust estimators adaptive to the proportion of contamination. Applying the general theory, we construct robust estimators for nonparametric density estimation, sparse linear regression and low-rank trace regression. We show that these new estimators achieve the minimax rate with optimal dependence on the contamination proportion. This testing procedure, Scheﬀ´e estimate, also enjoys an optimal rate in the exponent of the testing error, which may be of independent interest.
of cognitive-affective and socio-demographic factors with prior canal boat tour

This study applies complexity theory to explain how a cognitive-affective model indicates canal boat tour participants ’ desired behaviour. An in-situ survey was administered to collect data from 202 boat tour participants following a tour of the Canal du Faux-Rempart in Strasbourg, France. The study applies an asymmetrical analysis to investigate the cognitive-affective factors deriving participants ’ intentions to recommend canal boat tours. This study uses an asymmetrical approach to explore causal recipes from three configurations of socio-demographic factors with prior experience and cognitive and affective factors, leading to both high and low scores of recommendation intention. An analysis of necessary conditions was performed to identify the factors required to achieve the expected outcome. The results revealed that complexity theory supports causal interactions, leading to intention to recommend. Overall image, perceived quality, emotion and satisfaction are necessary factors to recommend canal boat tours. We discuss the theoretical and practical implications. from the affective configurations, a combination of cognitive-affective configurations and a combination of cognitive-affective factors with socio-demographic configurations to predict high intention to recommend. The results show that a combination of low satisfaction and high emotion would lead participants to highly recommend the canal boat tour (coverage: .309, consistency: .953). The fsQCA results from the combination of cognitive and affective factors for predicting intention to recommend suggest
Results Stimulus Requirements for Optimal Release of L ymphokines

The production of a number of polypeptide mediators or lymphokines underlies many of the differentiated functions of T lymphocytes including their capacity to influence B cells, macrophages, killer cells, as well as a variety of nonleukocytes. Lympbokine release begins when T cells are stimulated with antigen or mitogen. It quickly ceases when the stimulant is removed. A primary control is at tbe level of gene transcription. The stimulation of resting T cells, or the restimulation of isolated lymphoblasts and T cell lines, induces the formation of active lymphokine mRNA (1-5). Evidence that lymphokine mRNA levels are subject to distinct controls has come fi'om studies of the immunosuppressive drug, cyclosporin A (CsA)J This cyclic peptide blocks the production of several lymphokines but has minimal effects on the expression and function of the T cell's receptor for growth factor or 1L-2 (IL-2-R) (1, 3). Several recent studies (1-4) indicate that the mechanism of action of CsA is to inhibit the synthesis of lymphokine mRNA that is initiated upon addition of mitogens. CsA blocks the production of IL-2 mRNA as assessed by nuclear transcription and northern blotting assays, as well as the mRNAs for several other lymphokines (IFN-3,, B cell-, and cytolytic T cell-stimulating factors) as shown with oocyte translation systems (1-4). Another control of lymphokine mRNA appears to be an endogenous protein, which in some way downregulates the level of IL-2 message (6, 7). We have used DNA-RNA blotting to further analyze the control oflymphokine mRNA levels. The initial goal was to use a large panel of DNA probes to compare lymphokine and nonlymphokine gene expression in terms of kinetics, mitogen requirements, and sensitivity to CsA. The probes identified the mRNAs for the protooncogenes c-fos, c-myb, and c-myc, the IL-2-R, the lymphokines IL-2 and IFN, and the 70 kD heat shock protein (HSP). The results show that lymphokine and nonlymphokine mRNAs are induced by distinct exogenous stimuli. However, IL-2 and IFN mRNAs share with c-myc certain intracellular controls, including kinetics of mRNA accumulation and sensitivity to CsA.
Short- and long-term of 56Fe irradiation on cognition and hippocampal DNA methylation and gene expression.

Background: Astronauts are exposed to 56 Fe ions that may pose a significant health hazard during and following prolonged missions in deep space. We showed previously that object recognition requiring the hippocampus, a structure critical for cognitive function, is affected in 2-month-old mice irradiated with 56 Fe ions. Here we examined object recognition in 6-month-old mice irradiated with 56 Fe ions, a biological age more relevant to the typical ages of astronauts. Moreover, because the mechanisms mediating the detrimental effects of 56 Fe ions on hippocampal function are unclear, we examined changes in hippocampal networks involved in synaptic plasticity and memory, gene expression, and epigenetic changes in cytosine methylation (5mC) and hydroxymethylation (5hmC) that could accompany changes in gene expression. We assessed the effects of whole body 56 Fe ion irradiation at early (2 weeks) and late (20 weeks) time points on hippocampus-dependent memory and hippocampal network stability, and whether these effects are associated with epigenetic changes in hippocampal DNA methylation (both 5mC and 5hmC) and gene expression. Results: At the two-week time point, object recognition and network stability were impaired following irradiation at the 0.1 and 0.4 Gy dose, but not following irradiation at the 0.2 Gy dose. No impairments in object recognition or network stability were seen at the 20-week time point at any irradiation dose used. Consistent with this pattern, the significance of pathways for gene categories for 5hmC was lower, though not eliminated, at the 20-week time point compared to the 2-week time point. Similarly, significant changes were observed for 5mC gene pathways at the 2-week time point, but no significant gene categories were observed at the 20-week time point. Only the 5hmC changes tracked with gene expression changes. Conclusions: Dose- and time-dependent epigenomic remodeling in the hippocampus following 56 Fe ion exposure correlates with behavioral changes.
CMAR_A_235500 11649..11661

*These authors contributed equally to this work Purpose: Previous studies found that gap junction alpha-1 protein (GJA1) was a potent tumor suppressor in colorectal cancer (CRC). We designed the present study to evaluate the clinical importance and molecular mechanisms of GJA1 in CRC. Methods: Clinical and transcriptomic data from TCGA and GEO datasets were retrospectively collected. CRC patients were divided into two subgroups according to the expression level of GJA1 mRNA. Difference between survival time and response to neoadjuvant chemotherapy was then evaluated. Functional assays including wound-healing assay, transwell invasion assay and flow cytometry assay were performed to investigate the effects of GJA1 on invasive ability and response to chemotherapy drugs of CRC cells. Moreover, we explored the mechanisms of GJA1 by which it regulates CRC malignant phenotypes. Results: The expression level of GJA1 was significantly higher in normal tissue than cancer tissue, indicating a tumor suppressive role of GJA1 in CRC. Patients with higher expression of GJA1 showed better prognosis than those with low GJA1 expression level. Consistently, overexpression of GJA1 suppressed the invasive ability of CRC cells while enhancing the sensitivity of CRC cells to oxaliplatin-induced apoptosis. Mechanically, we found that GJA1 suppressed the epithelial mesenchymal transition process. Moreover, GJA1 could modulating infiltrating levels of several immune cells in the tumor microenvironment. Conclusion: These findings suggested that GJA1 was correlated with prognosis and immune infiltrating levels of CD8+ T cells, macrophages, neutrophils, and DCs in CRC. In addition, GJA1 expression contributes to regulation of tumor-associated macrophages (TAMs) and tumor infiltrating neutrophils (TINs) in CRC. These findings suggest that GJA1 is a promising biomarker for determining prognosis and immune infiltration in colorectal cancer.
Effect of Production Gap on Farm Income of Young Catfish Producers in Oyo State, Nigeria

The study examined the effect of production gap in catfish enterprise in Oyo State, Nigeria. Two Local Government Areas (LGAs) were purposely selected based on the high concentration of Catfish producers. A simple random sampling technique was then used to select 80 farmers from the list of registered catfish producers in the LGAs. Data collected were analyzed using descriptive statistics, budgetary and multiple regression analyses. The findings revealed that Catfish enterprise in the study area is dominated by male, who were married with mean age of 36.65 years and 5.57 years of production experience, average household size of 5 members with high (15.4) years of formal education. A wide production gap was observed among farmers averaged 0.23kg and 93% of the respondents produced below the expected average weight of 0.99kg. The enterprise was profitable, on every ₦1 invested, there was a return of ₦1.81. Also, the effect of production gap on net income was found to be significant and negative. Other variables that affected net income were age and years of experience. While years of experience had positive effect on net income, age had negative effect on it. It was concluded that many farmers are producing below the expected output. Therefore, young fish farmers need target training on best management practices in catfish production to bridge the gap between the expected average and actual average output in Catfish production.
The Inﬂuence of Environmental Strategy, Environmental Reporting and Environmental Management Control System on Environmental and Economic Performance

: The importance of corporate social responsibility, especially in the environmental domain, continues to grow in an era of mounting climate urgency. This study is based on original, empirical, survey-based research in two post-communist European countries and seeks to add a geographical viewpoint and to investigate the inﬂuence of innovative constructs (environmental reporting, environmental strategy, environmental management control system) on environmental and economic performance. Data are analysed through partial least squares structural equation modelling, which enables the use of a complex model with several links between constructs. Findings reveal that environmental strategy has a positive impact on the use of an environmental management control system and an indirect positive impact on environmental performance. The environmental management control system has been shown to have a positive inﬂuence on environmental performance and, ultimately, on economic performance.
Immunological Evidence for Functional Rather than Structural Mimicry by a Shigella ﬂexneri Y Polysaccharide-Mimetic Peptide (cid:1)

An approach to vaccine design is the use of molecules that mimic the immunogenic element of interest. In this context, the interaction of MDWNMHAA, a peptide mimic of the Shigella ﬂexneri Y O polysaccharide (PS), with an anti-carbohydrate monoclonal antibody, as studied previously by X-ray crystallography, suggested the presence of functional rather than structural mimicry and a bound peptide conformation that was not represented signiﬁcantly in the free-ligand ensemble. The antibody response elicited by an MDWNMHAA- carrier protein (tetanus toxoid [TT]) conjugate has now been investigated in BALB/c mice. The mice were immunized following a homologous prime/boost strategy using MDWNMHAA-TT as the immunogen. The mice showed anti-peptide antibody (immunoglobulin G [IgG]) titers that increased after being boosted. High anti-lipopolysaccharide (LPS) (IgG) titers were observed after the last boost. A faster immune response, with cross-reactive titers, was observed with a peptide conjugate with 30% more copies of the peptide. The binding of anti-peptide polyclonal antibodies to LPS could be inhibited by LPS, PS, MDWNMHAA, and MDWNMH AA-bovine serum albumin, as assessed by inhibition enzyme-linked immunosorbent assay. Conversely, mice immunized with PS-TT showed IgG anti-peptide titers. These data demonstrate the cross-reactivity of the antibody response and support the hypothesis that functional, as opposed to structural, mimicry of the S. ﬂexneri Y O PS by MDWNMHAA or the underrepresentation of the bound ligand conformation in the free-ligand ensemble does not compromise immunological cross-reactivity. Prime/boost strategies were per- formed with a heterologous boost of PS-TT or MDWNMHAA-TT. They led to high anti-LPS titers after only three injections, suggesting alternatives to improve the immunogenicity of the carbohydrate-mimetic peptide and conﬁrming the antigenic mimicry.
Donor and Recipient Envs from Heterosexual Human Immunodeﬁciency Virus Subtype C Transmission Pairs Require High Receptor Levels for Entry (cid:1)

Compact, glycan-restricted envelope (Env) glycoproteins are selected during heterosexual transmission of subtype C HIV-1. Donor and recipient glycoproteins (Envs) from six transmission pairs were evaluated for entry into HeLa cells expressing different levels of CD4 and CCR5. Donor and recipient Envs demonstrated efﬁcient entry into cells expressing high levels of CD4 and CCR5, and entry declined as CCR5 levels decreased. Infectivity for all Envs was severely impaired in cells expressing low levels of CD4, even at the highest CCR5 levels. In 5/6 pairs, there was no signiﬁcant difference in efﬁciency of receptor utilization between the donor and recipient Envs in these HeLa-derived cell lines. Thus, HIV-1 transmission does not appear to select for viruses that can preferentially utilize low levels of entry receptors.
ASSOCIATION BETWEEN GENETIC POLYMORPHISMS OF DNA REPAIR GENES (XPC, XPG) AND HEAD AND NECK CANCER SUSCEPTIBILITY IN INDIAN POPULATION: A HOSPITAL BASED CASE-CONTROL STUDY.

Background: Smoking and alcohol related head and neck cancer is a major concern of health risk in rural parts of developing countries, such as India. In this study, we aimed to determine the frequency of polymorphisms in DNA repair gene, Xeroderma pigmentosum complementation group C ( XPC ) and Xeroderma pigmentosum complementation group G ( XPG ) in patients of oral cancer from western Maharashtra and to evaluate their association with oral cancer development. Methods: We used polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) to analyze XPC & XPG gene polymorphisms in 320 patients with oral cancer and in 400 age and sex matched disease-free controls. Results: The result from our study showed that allele frequencies of selected genes were not statistically different between the groups for XPC Gln939, XPGAsp1104. XPC Intron 11 (OR= 4.65; 95% CI= (3.16-6.85); p = <0.0001) genotypes significantly increased the risk of head and neck cancer. Conclusions: This study indicates that polymorphisms in intron11 of XPC gene could play a role in modifying genetic susceptibility of individual to head and neck cancer in Maharashtra patients. The case-control study suggests that selected DNA repair genes represent genetic determinants in oral carcinogenesis along with other environmental risk factors in the unexplored rural Indian population.
STUDY OF VITAMIN B12, FOLATE AND ADIPOKINES WITH RESPECT TO INSULIN RESISTANCE (IR) AND ANTHROPOMETRY (BIRTH WEIGHT AND BMI) IN CHILDREN (AGE 10 – 20 YEARS)

[17] Limited data suggests ABSTRACT Background : Childhood obesity is set to increase phenomenally in India in near future. Birth weight a reflection of maternal nutrition and fetal programming, which may predict the cause of obesity. Micronutrients (Vitamin B12, Folate) and Adipokines (adiponectin and leptin) also play an important role in development of insulin resistance and obesity. The aim of the study is to evaluate the combined effect of micronutrients and adipokines on insulin resistance in Indian school-going children in the age group of 10–20 years. This study also describes distribution of micronutrient concentrations and it’s interrelationship with birth weight, body mass index (BMI), and insulin resistance. Methods : A cross-sectional study involves a total of 200 school going children between the age group of 10-20 yrs. Fasting plasma glucose, insulin, adiponectin, leptin, Vitamin B12, and folate were measured for the school going children and birth weight was recorded. BMI body mass index was defined as weight (kg) divided by height (m) squared. Insulin resistance was assessed using the homeostasis model (HOMA-IR). Results : Birth weight was not related to folate concentration but inversely to leptin and insulin resistance. Obese Children had higher leptin, birth weight, insulin with lower folate, and adiponectin levels. Conclusion : Adipokines partially protect fat induced obesity. Leptin induces insulin resistance and inflammation. Insulin resistance, leptin, and adiponectin were associated with fat mass. Folate consumption protects from developing obesity and adiposity. However the relationship of birth weight and BMI with micronutrients and adipokines needs further evaluation.
Highly heterogeneous mantle sampled by rapidly erupted carbonate volcanism

The Calatrava volcanic province (CVP) comprises over 200 vents. All of the vents may have erupted carbonate rich volcanism, making it the largest extrusive carbonatite province known. Volcanism in Calatrava was active in the late Miocene to Quaternary (8.71.6Ma Lopez-Ruiz, 1993) associated with a period of rifting, postulated to be related to lithospheric relaxation following the Alpine-Betic orogeny.