Miracle-dz/UniFAR-FTUs huggingface dataset:
OTT_A_275452 11755..11768

1Department of Neurosurgery, The First Hospital of China Medical University, Shenyang, People’s Republic of China; 2Department of Surgical Oncology and Breast Surgery, The First Hospital of China Medical University, Shenyang, People’s Republic of China; 3College of Applied Technology, China Medical University, Shenyang, Liaoning 110122, People’s Republic of China Purpose: Glioblastoma (GBM) is the most lethal primary cancer in adult central nervous system, and new strategies are desperately needed. The secretory pathway kinase or kinaselike proteins (SPKKPs) have been shown to mediate multiple physiological functions by phosphorylating extracellular proteins and proteoglycans. However, their roles in cancers, especially GBM, remain poorly defined. Methods: The least absolute shrinkage and selection operator (LASSO) regression was employed for establishing the SPKKPs signature for IDH wild type (wt) GBM prognosis. Integrative analyses with multiple datasets were employed to identify the core member of this gene family in glioma. The receiver operator characteristic (ROC) curves and immunohistochemistry were further used for evaluating its association with progressive malignancy in glioma and GBM patients’ survival, respectively. Gene set enrichment analysis (GSEA) and Kyoto Encyclopedia of Genes and Genomes (KEGG) were used to interpret its functions in GBM, which were further verified in vitro. Results: A SPKKPs classifier was constructed with 3 genes of this family. This signature could effectively distinguish IDH wt GBM survival. Family with sequence similarity 20 C (FAM20C) was further identified as the core member of this family in glioma. Elevated FAM20C expression was not only closely correlated with glioma malignancy progression and the mesenchymal subtype of GBM but also indicated unfavorable survival of GBM patients. FAM20C was also found to be associated with the disrupted immune response in GBM microenvironment and was required for the migration of glioma and immune cells. Conclusion: These data indicate that the potential of FAM20C serving as a predictive molecule and a therapeutic target for GBM.
by organize lipid synthesis in

transfer mitochondrial Mitochondria cellular lipid metabolism synthesis of major constituents of cellular membranes, such phosphatidylethanolamine (PE) phosphatidylcholine. Here, we demonstrate that the phosphatidylserine decarboxylase Psd1, located in the inner mitochondrial membrane, promotes mitochondrial PE synthesis via two pathways. First, Ups2–Mdm35 complexes (SLMO2–TRI AP1 in humans) serve as phosphatidylserine (PS)-specific lipid transfer proteins in the mitochondrial intermembrane space, allowing formation of PE by Psd1 in the inner membrane. Second, Psd1 decarboxylates PS in the outer membrane in trans, independently of PS transfer by Ups2–Mdm35. This latter pathway requires close apposition between both mitochondrial membranes and the mitochondrial contact site and cristae organizing system (MIC OS). In MIC OS-deficient cells, limiting PS transfer by Ups2–Mdm35 and reducing mitochondrial PE accumulation preserves mitochondrial respiration and cristae formation. These results link mitochondrial PE metabolism to MIC OS, combining functions in protein and lipid homeostasis to preserve mitochondrial structure and function.
DMSO_A_272802 3433..3448

1Centre for Nutrition, Department of Clinical Medicine, University of Bergen, Bergen, Norway; 2Section of Gastroenterology, Department of Medicine, Haukeland University Hospital, Bergen, Norway; 3National Centre of Functional Gastrointestinal Disorders, Haukeland University Hospital, Bergen, Norway Abstract: There is an increasing number of people who convert to a plant-based diet. The desire for health benefits, including weight management, is often a contributing factor behind this dietary choice. The purpose of this review was to evaluate intervention studies assessing the effects of different plant-based diets on body mass index and weight. A literature search was conducted in PubMed until December 2019. Twenty-two publications from 19 studies were included. The majority of them were randomized controlled trials comparing a low-fat vegan diet to an omnivore diet in participants with overweight, type 2 diabetes mellitus and/ or cardiovascular disease. All studies reported weight reductions, of which seven revealed significant differences, and four revealed non-significant differences between the intervention and the control groups. The results suggest that plant-based diets may improve weight status in some patient groups. Due to restrictions in fat intake in many studies, followed by reduced energy intake, the effects of the different interventions differ depending on the specific plantbased diets investigated. Future research should aim to include a representative study population and apply study diets without dietary restrictions.
Effects of donor, pancreas and isolation-related variables on human islet isolation outcome: a review

Different factors have been reported to influence islet isolation outcome, but vary between studies and are hampered by small study samples per study. The purpose of this study was to perform a systematic review to assess the impact of donor, pancreas and isolation-related variables on successful human islet isolation outcome. Methods Materials All studies reporting on donor, and factors relating to pre-purification, post-purification islet isolation and proportion of successful isolations 74 retrospective
Title: Attitudes towards childbearing, causal attributions for bipolar disorder and psychological distress: A study of families with multiple cases of bipolar disorder. Short disorder

: Background: For families with multiple cases of bipolar disorder this study explored: attitudes towards childbearing; causal attributions for bipolar disorder, in particular the degree to which a genetic model is endorsed and its impact on the perceived stigma of bipolar disorder; and predictors of psychological distress. Methods: Two hundred individuals (95 unaffected and 105 affected with either bipolar disorder, schizoaffective disorder - manic type, or recurrent major disorder) were surveyed, using mailed, self-administered questionnaires. Results: Sixty-five (35%) participants reported being ‘not at all’ or ‘less willing to have children’ as a result of having a strong family history of bipolar disorder. Being not at all or less willing to have children was associated with perceived stigma of bipolar disorder ( OR =2.42, p =0.002), endorsement of a genetic model ( OR =1.76, p =0.046), and being affected ( OR =2.16, p =0.01). Among unaffected participants only, endorsement of a genetic model was strongly correlated with perceived stigma ( r s =0.30, p =0.004). Conclusions: Having a genetic
Construction and Validation of a Nomogram to Predict Overall Survival in Very Young Female Patients with Curatively Resected Breast Cancer

Purpose: Young age is an independent negative predictor of breast cancer (BC) survival and correlates with the risk of local recurrence and contralateral BC. We aimed to design an effective and comprehensive nomogram to predict prognosis in very young patients with curatively resected BC. Methods: Female patients with a diagnosis of BC aged ≤35 years at presentation were identified from the SEER database as a training cohort. The validation cohort consisted of 1002 consecutive women with BC aged ≤35 years that had received curative resection for BC at the Sun Yat-sen University Cancer Center. A nomogram was built based on the identified variables in multivariate Cox proportional hazards model. The performance of the nomogram was quantified using Harrell’s concordance index (C-index) and calibration curves. Results: Overall, 10,872 young female patients who underwent surgery for BC were enrolled in the training cohort, while 1002 very young female BC patients were identified as independent validation cohort. Eight covariables (age, race, grade; ER, PR, and HER2 status; T, and N stages) were identified and incorporated to construct a nomogram. The C-index values of the nomogram were 0.727 (95% CI: 0.714–0.740) and 0.722 (95% CI: 0.666–0.778) for OS in the training and validation cohorts, respectively. The calibration curves showed a high degree of agreement between the predicted and actual observed survival rates in both training and validation cohorts. The nomogram displayed good calibration and acceptable discrimination. Based on the TPS of the nomogram model for OS with the X-tile program, patients were divided into 3 risk groups, which were easily discriminated on survival analyses for OS. Conclusion: We have successfully constructed an effective nomogram to predict survival outcomes for young female patients with curatively resected BC, which may provide individual survival prediction to benefit prognosis evaluation and individualized therapy.
Long Non-Coding RNA TTN-AS1 Promotes the Proliferation and Invasion of Colorectal Cancer Cells by Activating miR-497-Mediated PI3K/Akt/ mTOR Signaling

Introduction: Long non-coding RNAs (lncRNAs) have obtained increasing attention due to their regulatory functions in many cancers. This work aimed to investigate the functional roles of lncRNATTN-AS1 in colorectal cancer (CRC) and to explore the underlying mechanisms. Methods: The expression pro ﬁ les of TTN-AS1 and miR-497 in CRC tissues and cell lines were determined by RT-qPCR analysis. MTT assay, transwell assay, western blot analysis, and xenograft tumors in nude mice were employed to analyze the effects of TTN-AS1 on the proliferation, migration, invasion, EMT, and in vivo tumorigenesis of CRC cells. Bioinformatics analysis and dual-luciferase reporter assay determined the direct binding relation between TTN-AS1 and miR-497 in CRC. Results: We observed a signi ﬁ cant increase of TTN-AS1 expression level in CRC tissues and cell lines compared with normal counterparts. High expression of TTN-AS1 predicted a poor prognosis and was correlated with aggressive clinicopathological characteristics in CRC patients. Functionally, gain- and loss-of-function studies indicated that TTN-AS1 knockdown suppressed the proliferation, migration, invasion and epithelial – mesenchymal transition of CRC cells in vitro, whereas TTN-AS1 overexpression showed the complete opposite effects. Mechanistically, we found that TTN-AS1 could directly interact with miR-497, and co-transfection with miR-497 mimics blocked the activation of PI3K/Akt/ mTOR signaling, and reversed the effects of TTN-AS1 overexpression in CRC cells. Conclusion: To conclude, our ﬁ ndings provide novel insight into CRC tumorigenesis and indicate that TTN-AS1 may serve as a potential therapeutic target for CRC treatment.
Assessment of Environmental Impacts of Limestone Quarrying Operations in Thailand

Abstract Environmental impacts of the mineral extraction have been a public concern. Presently, there is widespread global interest in the area of mining and its sustainability that focused on the need to shift mining industry to a more sustainable framework. The aim of this study was to systematically assess all possible environmental and climate change related impacts of the limestone quarrying operation in Thailand. By considering the life cycle assessment method, the production processes were divided into three phases: raw material extraction, transportation, and comminution. Both IMPACT 2002+ and the Greenhouse Gas Protocol methods were used. Results of IMPACT 2002+ analysis showed that per 1 ton crushed limestone rock production, the total depletion of resource and GHGs emissions were 79.6 MJ and 2.76 kg CO2 eq., respectively. Regarding to the four damage categories, ‘resources’ and ‘climate change’ categories were the two greatest environmental impacts of the limestone rock production. Diesel fuel and electricity consumption in the mining processes were the main causes of those impacts. For climate change, the unit of CO2 eq. was expressed to quantify the total GHGs emissions. Estimated result was about 3.13 kg CO2 eq. per ton limestone rock product. The results obtained by the Greenhouse Gas Protocol were also similar to IMPACT 2002+ method. Electrical energy consumption was considered as the main driver of GHGs, accounting for approximately 46.8 % of total fossil fuel CO2 emissions. A final point should be noted that data uncertainties in environmental assessment over the complete life cycle of limestone quarrying operation have to be carefully considered.
ALGEBRAIC SURFACES WITH k*-ACTION

Let k be an arbitrary algebraically closed field and let k* denote the multiplicative group of k considered as an algebraic group. We give a complete classification of all non-singular projective algebraic surfaces with k*-action. Moreover, for singular surfaces we provide an algorithm for finding an equivariant resolution. Explicit computations are given for hypersurfaces in pa. The topologically significant case emerges when k = C, the complex numbers, when non-singular surfaces are smooth orientable closed 4-manifolds with C*-action. This was the case studied in our earlier papers [16, 17, 18]. In order to facilitate the reading of the present paper for the reader whose main interest lies in these topological aspects, we have included geometric motivation for several of our algebraic constructions. I t is clear from the naturality with which these constructions can be extended to the general case that it is appropriate to treat the problem from the point of view of algebraic geometry. The paper is organized as follows. In section I the necessary tools are introduced both from transformation group theory and algebraic geometry. We prove a number of lemmas about actions in general, needed later in the paper. In section 2 we focus our attention on non-singular algebraic surfaces with k*-aetion. The fixed points of a k*-action are divided into three classes; elliptic, hyperbolic and parabolic (w A "topological" classification of non-singular surfaces with no elliptic fixed points is obtained in w 2.5. The classification theorem states that the fixed point set is F = F + U F-U {x 1 . xr} , where the x, are hyperbolic fixed points and F + and F are isomorphic complete curves. More-
Assessing GPR on IDFs in Alaska and New Zealand

Page 10 of 18 Planned publication in JEEG, December 2018, Volume 23, Issue 4 Table 4 presents the results of semblance analysis from the WARR soundings collected only on the McCarthy Glacier. In addition, an example of one of these WARR soundings (CMP3) and associated semblance analysis is provided in Fig. 6. The radargram from CMP3 (Fig. 6a) is representative of the CMP soundings collected in this study, where the GPR events have either linear moveout with Tx-Rx offset, or normal moveout with TxRx offset, i.e. traveltime increases as offset increases. The NMO velocity for CMP3 does not change significantly with depth, notice that the peak semblance amplitudes in Fig. 6b occur between 0.16 and 0.17 m/ns to a TWTT of 1104 ns. Table 4. Velocity analysis results from WARR soundings on McCarthy Glacier, Alaska. CMP2 was collected near a large moulin. CMP3 and CMP4 were collected at the same mid-point.
VASE LIFE OF CUT ROSE ( Rosa hybrida L.) AGAINST EASY TO READY UP DIFFERENT AVAILABLE SOLUTIONS

In experiment, C 0 : tap water (Control), C 1 : distilled water, C 2: sucrose solution (100 ppm), C 3: lemon juice solution (100 ppm), C 4 : sucrose + lemon juice solution (100 ppm) and C 5 : GA 3 solution was examined to assess vase life of cut rose ( Rosa hybrida L.). Experiment was accomplished at the Department of Horticulture, Sher-e-Bangla Agricultural University, Dhaka, Bangladesh September 2012 to September 2013. C 4 illustrated minimum flower diameter (99.0 mm) with maximum petal number (40.0 petals) and ceiling petal thickness (0.25 mm) on 8 th days after treating. Least stem bending (14.3 0 C), petal discoloration score (2.0), freshness of flower (2.5) on 8 th days after treating were exposed by C 4 . Utmost flower longevity (14.0 days) also revealed on C 4 whereas least flower longevity was traced in C 0 and C 5 (8.5 days).
ASSESSMENT OF TORQUE LOSS IN COMMERCIALLY AVAILABLE IMPLANT/ ABUTMENT SYSTEMS: AN IN VITRO PILOT STUDY

Aims: The aim of this in vitro pilot study was to assess the torque loss on repeated tightening and loosening of implant abutment screw in commercially available implant systems. Methods and Material: 2 implant systems were tested with 10 samples in each system. Group A and Group B (n= 10) with connection type morse taper (ADIN GLOBAL IMPLANT SYSTEM) and internal hex (CMI IMPLANT SYSTEM) respectively. Mock osteotomy sites were created in resin blocks and implant analogs were placed. Abutments were placed onto the implant analogs at a torque of 30 Ncm. After 20 minutes the abutment screw was detorqued and the value was noted using digital torque wrench . This procedure was repeated 10 times for each sample.Torque loss and percentage torque loss were calculated. Statistical analysis used: Descriptive statistics displayed in the form of frequency and percentage. Differences in torque were assessed using ANOVA (p<0.05). Results: The mean value of torque at first reading for Group A and Group B were ( Rt ¹) =30.82 ±0.42 Ncm and (Rt ¹) = 31.15 ±0.17 Ncm respectively and at tenth reading were (Rt ¹º) = 32.64 ±0.27 Ncm and (Rt ¹º) = 32.85 ±0.42 Ncm respectively. Conclusions: A progressive decrease in opening torque values was measured in both implant systems. The percentage of torque loss ranged from 1.2 -2.3 % for Group A and 2.2 – 6.45% for Group B. The mean torque loss between Group A and Group B was not statistically significant at p<0.05
The W Charge Asymmetry: Measurement of the Proton Structure with the ATLAS detector

The charge asymmetry in the production of W± bosons in pp collisions is dependent on the momenta of the partons participating in the Drell-Yan process. It is a sensitive probe in particular to the u and d valence quark distributions, that are only loosely constrained in the kinematic range of the LHC pp collider. A measurement of theW charge asymmetry will be crucial to understand the initial states of pp collisions at the LHC centre of mass energy of √ s =14 TeV. In this thesis a weighting technique to measure the W charge asymmetry at the LHC is evaluated and discarded as not sound in the kinematic range of the collider. Therefore, the prospects of a measurement of the lepton charge asymmetry at √ s = 14 TeV with 100 pb−1 as a function of the pseudorapidity of the lepton are investigated using simulated data of the ATLAS detector. This includes a full and thorough analysis of the systematical errors. For 100 pb−1, the expected total percentage errors are found to be between 5-10%. These relative errors are a factor of 0.5-0.8 below the PDF uncertainties, which are about 15% in the kinematic range of the LHC. Hence an early measurement of the W asymmetry will be crucial to put constraints on the PDFs. Fur Karl Lang und Gerald Karl Lohwasser We shall not cease from exploration And the end of all our exploring Will be to arrive where we started And know the place for the first time. T.S. Eliot, Little Gidding, Four Quartets
CPAA_A_269156 115..121

1Department of Pharmacy, Shree Birendra Hospital; Nepalese Army Institute of Health Sciences, Kathmandu 44600, Nepal; 2Department of Emergency Medicine and General Practice, Mangalbare Hospital, Morang 56600, Nepal; 3Department of Emergency Medicine and General Practice, Dr Iwamura Memorial Hospital, Bhaktapur 44800, Nepal; 4Department of Emergency Medicine and General Practice, Kathmandu Medical College, Kathmandu 44600, Nepal Abstract: Coronavirus disease (COVID-19) pandemic has been a global disease burden. It has affected more than sixteen million people in the world within seven months of its first outbreak in Wuhan. Different treatment modalities, therapeutic and prophylactic agents for its therapy are underway. Until the proven therapy gets available, repurposing of drugs is a better way out. Hydroxychloroquine (HCQ) has been a potential recourse of treatment in this regard for COVID-19 management. As different episodes of cardiac adverse events of HCQ are reported, safety concerns are now a prime objective. The risk-benefit analysis is mandatory to address rational drug therapy even in such a global health crisis. In this article, we want to evaluate the safety and efficacy of HCQ in COVID-19 management.
OPTH_A_258817 3563..3573

1Ophthalmology Clinic Vista Sánchez Trancón, Badajoz, Spain; 2Centre of Physics, University of Minho, Braga, Portugal; 3Optics and Optometry Department, Instituto Superior de Educação e Ciências, Lisbon, Portugal Purpose: The distance between an implantable collamer lens (ICL) and the crystalline lens, namely vault, is a space regulated by the interaction of the ICL and the anatomical structures of the eye. This study analysed the differences in vault size between fellow eyes with similar anterior segment biometry. Patients and Methods: A retrospective case series analysed 109 cases of patients bilaterally implanted with EVO-V4c. Patients were analysed preand postoperatively using anterior segment optical coherence tomography. The range of vault inter-eye differences was defined as the 95% confidence interval of the differences. Bivariate correlation was applied to seek for associations between vault inter-eye differences with biometric and lens parameters (angle-to-angle, anterior chamber depth, crystalline lens rise, central corneal thickness, central keratometry, ICL spherical equivalent, horizontal compression, postoperative pupil diameter and vault). Results: Mean vault inter-eye differences were similar between fellow eyes (26.0 ± 122.5 μm). The 95% confidence interval range of the differences was ±240.1 μm, nearly 50% of the cases presented vault inter-eye differences higher than 100 μm. The vault of the first operated eye explained 81% of the variance in the second eye vault. Vault inter-eye differences were positively correlated with the level of horizontal compression and with vault magnitude. Conclusion: Vaults measured in fellow eyes may present considerable differences, which can reach 25% of the common vault range. This reflects some degree of baseline variability in the vault. Clinically, these differences assume special relevance in cases where low or high vaults are expected.
Oxygen Radicals and Nitrite Covalent Cross-Linking of Immune Complexes by

We have shown that polymorphonuclear neutrophils mediate the covalent cross-linking of immune complexes (ICs) using H 2 O 2 and myeloperoxidase (MPO). Moreover, activated superﬁcial chondrocytes produce large amounts of nitric oxide (NO), suggesting that high concentrations of these radicals may interact at the cartilage surface in rheumatoid arthritis. We describe the effects of the interaction of NO and its decay product, NO 2 , with H 2 O 2 and MPO on IC cross-linking. Cross-linking was measured by resistance to the guanidine extraction of plastic-bound ICs. The combination of H 2 O 2 , MPO, and NO in the absence of O 2 did not alter the magnitude of cross-linking. The addition of O 2 resulted in a signiﬁcant enhancement of cross-linking ( p < 0.004), suggesting that nitrite was responsible for the increase observed. Indeed, NaNO 2 greatly increased H 2 O 2 -dependent cross-linking (control: 29.2 6 3.8; 1 mM NaNO 2 : 58.4 6 9.9; 10 mM: 60.4 6 4.2% cross-linking, p < 0.0002). Sodium azide, which is an inhibitor of MPO, completely inhibited cross-linking. These results indicated that the product of interaction of H 2 O 2 and NO 2 mediated by MPO may be responsible for the increase in cross-linking. The generation of nitrotyrosine was demonstrated when NO 2 was added to the cross-linking system. Cross-linking was also shown with an O 2 2 -generating system and NO. Peroxynitrite alone mediated cross-linking (100 m M ONOO 2 : 40.3 6 1.9% cross-linking; p < 0.002), and the addition of MPO signiﬁcantly enhanced this effect (100 m M: 57.7 6 6.0%; p < 0.0002 with respect to no nitrite control). Oxygen radicals and NO are likely to interact at the cartilage