Miracle-dz/UniFAR-FTUs huggingface dataset:
The Impact of Different rs3917538 Genotypes with the PON-1 Activity, Atherosclerosis Severity in Patients of Coronary Atherosclerosis

Background: Coronary atherosclerosis is one of the coronary artery diseases (CAD) responsible for a significant percentage of mortality and morbidity in Iraqi subjects. Atherosclerosis compresses about 17 million death cases; 45% are under the age of 70. The improvement in atherosclerosis disease management paly a critical role in preventing this disease; despite that, new risk factors have been studied, including genetic studies. Many polymorphisms have been associated with coronary atherosclerosis in different ethnic populations. Paraoxonase is an enzyme located on HDL in serum. PON acts as a protective factor or agent against oxidative modification of LDL, suggesting that it could play an essential and influential role in atherosclerotic processes prevention. Objective: To evaluate the rs3917538 genotypes in the PON-1 gene associated with the coronary atherosclerosis risk and the effect of this single nucleotide polymorphism on the serum activity of PON-1 and the severity of coronary atherosclerosis. Methods: A case-control study included sixty patients diagnosed with coronary atherosclerosis and sixty healthy volunteers diagnosed with angiography examination. The study was carried out during the period from February 2019 till June 2020. Serum PON-1 was measured by fluorometric technique, and the genetic assessment was by RT-PCR technique. Results: The activity for PON-1 in patients was significantly lower than controls; the median activity of PON-1 in controls was 197.32 mU/ml, which was higher than that of patients (median =163.46 mU/ml). There was an impact of rs3917538 genotypes on the severity of the disease, P=0.041. The rs3917538 genotypes have no association with the risk of coronary atherosclerosis and the activity of PON-1. Conclusion: The measurement of serum PON-1 activity may help in the diagnosis of coronary atherosclerosis patients. The rs3917538 genotypes in the PON-1 gene among the patient’s group impact the severity of coronary atherosclerosis.
Inventory of Dating Stress: Initial psychometric evaluation and construct validity

There is limited research on dating stress, or stressful experiences related to the dating process (e.g., inconsistent communication, sudden lack of response, and rude behavior). Little attention has been given to classifying stressors involved with the pursuit of potential partners from initial contact to relationship formation. In the current study, we developed a novel measure for such experiences, the Inventory of Dating Stress (IDS). We investigated the factor structure and preliminary construct validity for the IDS in an online sample of adults (n = 478). Results revealed a reliable four-factor structure (Mixed Signals, Mismatch, Ambiguous Rejection, and Harassment) across 18 items and the IDS demonstrated initial construct validity. Overall, the current study offers evidence of preliminary psychometric support for the IDS as a measure of dating stress.
DIetary ASSessment (DIASS) Study: Design of an Evaluation Study to Assess Validity, Usability and Perceived Burden of an Innovative Dietary Assessment Methodology

During recent years, the integration of technology has substantially improved self-reported dietary assessment methods, such as food frequency questionnaires (FFQ), food records, and 24-h recalls. To further reduce measurement error, additional innovations are urgently needed. Memory-related measurement error is one of the aspects that warrants attention, which is where new smartphone technologies and ecological momentary assessment (EMA) approaches provide a unique opportunity. In this article, we describe the DIASS study, which was designed to evaluate an innovative 2-h recall (2hR) smartphone-based methodology, against traditional 24-h recalls, FFQ, and biomarkers, to assess both actual and habitual dietary intake. It is hypothesized that a 2-h reporting window decreases reliance on memory and reporting burden, and increases data accuracy. We included 215 men (28%) and women (72%), with a mean ± SD age of 39 ± 19 years and a mean ± SD BMI of 23.8 ± 4.0. Most participants were highly educated (58%). Response rates for the various dietary assessment methods were >90%. Besides the evaluation of the accuracy, usability, and perceived burden of the 2hR methodology, the study set-up also allows for (further) evaluation of the other administrated dietary assessment tools.
Comparative Study on Effect of Fenofibrate and Simvastatin in Streptozotocin Induced Diabetic Albino Rats

Background: Diabetes mellitus is one of the most common diseases in the world and number of patients with this disease increases every day. This disease with long time leads to harmful effects and has many complications as increase in blood pressure, disturbance in kidney functions and increase in blood lipids. It is, therefore, important to search for drugs which prevent harmful effects that result from diabetes mellitus. Objective: To study the effect of pioglitazone, fenofibrate and simvastatin treatment on diabetic albino rats. Materials and methods: A total number of 80 male albino rats weighing 150–200 g were obtained from Animal House, Assiut University (Assiut, Egypt) was used. They were housed at ordinary room temperature, exposed to natural daily light-dark cycles, fed with standard laboratory diet pellets and were given tap water. The standard diet was obtained from Animal Experimental Central. Results: Serum superoxide dismutase (SOD) increased significantly in diabetic rats treated with pioglitazone and diabetic rats treated with fenofibrate or simvastatin. Combination therapy of pioglitazone and simvastatin or fenofibrate have no synergistic effect on serum SOD. Serum glutathione (GSH) increased significantly in the diabetic rats treated with pioglitazone and the diabetic rats treated with fenofibrate or simvastatin. Combination therapy of pioglitazone and simvastatin or fenofibrate have no synergistic effect on serum GSH. Conclusion: The present study showed that treatment with fenofibrate or simvastatin did not increase body weight or lower blood glucose level of the diabetic albino rats significantly, but they improved significantly blood pressure, lipid profile, and serum level of antioxidants (GSH and SOD).
The Clinical Utility of Serial Procalcitonin and Procalcitonin Clearance in Predicting the ‎Outcome of COVID-19 Egyptian Patients

Sara I. Taha, Aalaa K. Shata, Shereen A. Baioumy, Shaimaa H. Fouad, Aya H. Moussa, Eman M. El-Sehsah, Dina E. Sallam, and Mariam K. Youssef Department of Clinical Pathology/Immunology, Faculty of Medicine, Ain Shams University, Cairo, Egypt. Department of Pulmonary Medicine, Faculty of Medicine, Ain Shams University, Cairo, Egypt Department of Microbiology and Immunology, Faculty of Medicine, Zagazig University, Zagazig, Egypt. Department of Internal Medicine / Allergy and Clinical Immunology, Faculty of Medicine, Ain Shams University, Cairo, Egypt. Department of Anesthesia, Intensive Care and Pain Management, Faculty of Medicine, Ain Shams University, Cairo, Egypt. Department of Medical Microbiology and Immunology, Mansoura Faculty of Medicine, Mansoura, Egypt. Department of Pediatrics / Pediatric Nephrology, Faculty of medicine, Ain Shams University, Cairo, Egypt. Department of Clinical Pathology/Hematology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
A pH- and Bioreducible Cationic Copolymer with Amino Acids and Piperazines for Adenovirus Delivery

Adenoviruses (Ads) are attractive nonviral vectors and show great potential in cancer gene therapy. However, inherent properties of Ads, including immunogenicity, nonspecific toxicity, and coxsackie and adenovirus receptor (CAR)-dependent cell uptake, limit their clinical use. To surmount these issues, we developed a pH- and glutathione-responsive poly(ethylene glycol)-poly(ꞵ-aminoester)-polyethyleneimine (PPA) for conjugation with Ad. The pH sensitivity of the PPA copolymer was elegantly tuned by substitution with different amino acids (arginine, histidine, and tryptophan), piperazines (Pip1, Pip2, and Pip3), and guanidine residues in the backbone of the PPA conjugate. PPA copolymer was further functionalized with short-chain cross-linker succinimidyl 3-(2-pyridyldithio)propionate) (SPDP) to obtain PPA-SPDP for facile conjugation with Ad. The PPA-conjugated Ad (PPA-Ad) conjugate was obtained by reacting PPA-SPDP conjugate with thiolated Ad (Ad-SH). Ad-SH was prepared by reacting Ad with 2-iminothiolane. The size distribution and zeta potential results of PPA-Ad conjugate showed an increasing trend with an increase in copolymer dose. From in vitro test, it was found that the transduction efficiency of PPA-Ad conjugate in CAR-positive cells (A549 and H460 cells) was remarkably increased at the acidic pH condition (pH 6.2) when compared with PPA-Ad conjugate incubated under the physiological condition (pH 7.4). Interestingly, the increase in transduction efficiency was evidenced in CAR-negative cells (MDA-MB-231 and T24 cells). These results demonstrated that biocompatible and biodegradable PPA copolymers can efficiently cover the surface of Ad and can increase the transduction efficiency, and hence PPA copolymers can be a useful nanomaterial for viral vector delivery in cancer therapy.
Pressure anomalies from the January 2022 Hunga Tonga‐Hunga Ha'apai eruption

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The moderating role of complaint handling on brand hate in the cancel culture

PurposeThis study investigates the moderating role of complaint handling between ideological incompatibility, symbolic incongruity, negative past experience and corporate social irresponsibility on brand hate.Design/methodology/approachThe study employs the Duplex Hate theory which assumes that hate is the manifestation of multiple factors. A survey-based self-administered questionnaire was used to collect data from 400 smartphone users at Rawalpindi and Islamabad, Pakistan.FindingsThe findings suggest that ideological incompatibility, symbolic incongruity, negative past experience and corporate social irresponsibility contributes to brand hate. The complaint handling (moderator) weakens the effects of ideological incompatibility and symbolic incongruity on brand hate.Practical implicationsThe research provides insights into the cancel culture and clarifies how brand hate can be controlled.Originality/valueEmpirical study on the antecedents of brand hate remains insufficient. The current study contributes to the brand hate literature by providing an understanding of the phenomenon of brand hate and by empirically examining the different antecedents responsible for causing the behavior. The study has also provided an additional determinant of brand hate, which is corporate social irresponsibility. The role of moderators for controlling brand hate is greatly ignored in the existing literature. The current work also extends previous studies by investigating a moderating factor for reducing brand hate, which is complaint handling.
Unravelling the implications of learning experiences on doctoral degree holders’ employment: empirical insights and avenues for further developments

ABSTRACT Doctoral degree holders may struggle to find a job, even though they possess the highest level of education delivered by universities. Whilst learning experiences’ quality has been argued to affect the doctoral degree holders’ ability to get a job, little is known about the relationship between these dimensions. To shed light on this issue, the article investigated secondary data collected from the 2018 national survey on doctoral degree holders in Italy. The respondents’ ability to get a job four to six years after the achievement of their doctoral degree was examined. A multinomial polytomous logistic regression model was designed to obtain evidence of the relationship between the perceived quality of learning experiences and the doctoral degree holders’ ability to get a job. The enrichment of learning experiences with practice-oriented educational activities enhanced the PhDs’ ability to get a job. People who were dissatisfied with their relationship with academics were more likely to be unemployed. Tailored interventions are needed to augment the quality of learning experiences and to increase the PhDs’ ability to get a job. Educational services’ co-production and the involvement of business partners in co-designing educational services might contribute positively to the doctoral degree holders’ ability to get a job.
Body Dysmorphic Disorder Symptoms: Prevalence and Risk Factors in an Arab Middle Eastern Population

Background The present study examined the prevalence of and risk factors for symptoms of body dysmorphic disorder (BDD) in the general population of Jeddah, a large port city in Saudi Arabia. Methods This cross-sectional study surveyed a convenience sample of 520 adults. We used a validated self-screening measure to assess BDD, the body dysmorphic disorder questionnaire (BDDQ). Results The prevalence of significant BDD symptoms among the general Saudi population was 8.8% (ie, those scoring above the cut off for BDD on the BDDQ). Over half (52%) of all respondents reported concerns about the attractiveness of their body parts, and of those expressing such concerns, 66% were preoccupied with these thoughts. Only 3% of all respondents opted for cosmetic surgery because of these concerns, and most of those individuals (69%) had only one surgery. Nearly 9% of all respondents reported that these concerns affected their relationships with family and friends. Almost 15% of all participants spent an hour or more each day thinking about these concerns. Patients who reported a history of depression were 3.8 times more likely to have BDD. Other variables included in the model predicting high BDD scores (eg, age, job status, and marital status) did not achieve statistical significance. Conclusion Significant symptoms of BDD (based on the BDDQ) are not uncommon among the general population of Jeddah, Saudi Arabia. Risk factors for this condition were female gender, younger age, being unmarried, and in bivariate and multivariate analyses, history of depression and female gender. These findings underscore the need for increased awareness by clinicians of this disorder, particularly when treating patients with depressive disorder, particularly among women.
Magnetic Integration of the LCL Filter in Grid-connected Inverters

LCL filter is widely used in grid-connected inverters due to its outstanding performance of attenuating the switching frequency current harmonics.An LCL filter has two individual inductors.Numbers of magnetic cores are required,and large volume has to be reserved for these two inductors.In order to reduce the core size,this paper proposed a decoupled magnetic integration method to combine the two discrete inductors together.However,the reluctance of the common core can hardly be zero,which leads to the coupling between the two inductors of an LCL filter.As a consequence,the attenuating ability of the LCL filter at high frequency would be weakened.In order to reduce the coupling coefficient to a satisfactory range,the suitable height and magnetic material of the common core are selected.Experimental results from both single-phase and three-phase grid-connected inverters validate the effectiveness of the proposed magnetic integration method.
THE INFLUENCE OF DOMINANT CULTURAL IDEALS ON THE MENTAL AND SEXUAL HEALTH OF HOMOSEXUAL MEN: An exploratory study of the “Bear” phenomenon

Este proyecto buscó comprender las posibles asociaciones entre la influencia de estos ideales culturales dominantes en la salud mental y sexual de los hombres homosexuales autoidentificados como “Osos”. Los participantes respondieron a cuestionarios estándar que evaluaban la homonegatividad internalizada, la ocurrencia de eventos heterosexistas, las preconcepciones antifemeninas hacia hombres homosexuales, el estado de ánimo y el recuento sindrómico de los factores asociados al estrés de las minorías y los factores de protección. Los resultados mostraron que la pérdida o ausencia de apoyo de las redes vinculares y el mayor consumo de nicotina fueron los factores que más afectaron a los participantes. Este impacto está asociado a la adhesión a los ideales heteronormativos y a las actitudes negativas contra las expresiones de género femeninas en los hombres, que parecen generar ansiedad difusa, la expectativa de sufrir acoso heterosexista y la homofobia internalizada. Estos hallazgos son importantes porque señalan asociaciones entre los comportamientos adaptados manifiestos de estos hombres a las expectativas hegemónicas que enmascaran conflictos psicológicos más profundos.
Potentiality of Trichoderma Species against Fusarium oxysporum f. sp. cucumerinum and Meloidogyne javanica Disease Complex in Cucumber Plants

Biological control is considered an important approach in the recent years for controlling many plant diseases. Trichoderma spp. is a unique genus with a wide range of activity against most important plant pathogens. In this investigation, we have evaluated antagonism of four species of Trichoderma (T. album, T. asperellum, T. hamatum and T. koningii) against rootknot nematode (Meloidogyne javanica) and Fusarium wilt disease (Fusarium oxysporum f. sp. cucumerinum) on cucumber plant at two locations (Giza and Sakha) under greenhouse conditions. Effect of Trichoderma on disease severity of F. oxysporum f. sp. cucumerinum and mortality of M. javanica (J2) were examined under laboratory conditions. Results indicate that all tested Trichderma spp. inhibited the mycelial growth of F. oxysporum f. sp. cucumerinum and gave high mortality % of M. javanica juveniles in vitro. The best antifungal activity was shown by T. album and T. hamatum against cucumber wilt pathogen. After 24 hours, T. hamatum and T. album had almost 100% nematode mortality. Under greenhouse conditions, a significant enhancement was found in growth parameters of cucumber treated with T. album and T. hamatum at two locations. The application of T. hamatum to soil infected with F. oxysporum and M. javanica resulted in the highest antagonistic effect at Giza location. All treatments caused a reduction in final population density of M. javanica whether in the presence of Fusarium or not. At Giza location, the treatment utilizing T. album were shown to be the most effective in lowering the total number of galls and egg masses on cucumber roots infected with nematodes. However, in the presence of Fusarium fungus + nematodes, T. hamatum was the best treatment. At Sakha location, no significant differences were observed among Trichoderma spp. when nematodes and fungus were used together. T. koningii with nematode only resulted in a lower number of egg masses. Most treatments were more effective in reducing M. javanica reproduction factor (RF) when the nematode was present alone. In both sites, the highest increase in chitinase activity was recorded with treatment by T. hamatum and Fusarium.
Leverage, Kepemilikan Institusional, Dan Transfer Pricing, Penghindaran Pajak: Profitabilitas Sebagai Variabel Moderasi

Purpose: This study aim to examine leverage, institutional ownership and transfer pricing, tax avoidance: profitability as moderating variablesMethod: The method in this study using purposive sampling method and obtained 40 companies with data processed 160 annual financial statements. This research technique uses multiple linear analysis and Moderated Analysis ModeratedFinding: The findings in this study that leverage has a negative effect on tax avoidance, institusional ownership has a positive effect on tax avoidance, and transfer pricing has a positive effect on tax avoidance. Profitability can weaken the negative effect of leverage on tax avoidance, profitability cannot moderate the positive effect of institutional ownership on tax avoidance, and profitability cannot significantly moderate the effect of transfer pricing on tax avoidance. Novelty: The difference between this study and previous research is that this research tries to integrate several topics regarding the variable of tax avoidance practices which are influenced by three variables including leverage, institutional ownership, and transfer pricing, using the moderating variable of profitability.
Effect of Low Protein Diets Supplemented with Glycine on Growth Performance Carcass Traits, Blood Parameters and Antioxidant Status of Mandarah Chicks During Starter and Grower Periods

The objective of this study was to evaluate the effect of low protein diet fortified with 0.2% glycine (gly) on Mandarah a native Egyptian strain chick’s growth performance, carcass, small intestinal morphology, shank and keel bone length, blood parameters, growth hormone and blood antioxidant status during starter and growing periods (from 1 day to 12 weeks of age). A total number of 135 one day old Mandarah chicks were randomly divided into 3 equal groups with 3 equal replicates each. Control group (C) was fed normal crude protein diets (19% CP as starter and 17% CP for grower), group 2 (LP1) and 3 (LP2) fed 1.5 and 3% less crude protein respectively, than control supplemented with 0.2% glycine. Results indicated that LP1diet supplementation with glycine led to significant improvement in body weight (BW) during the starter period, and in feed conversion ratio (FCR) during the first 4 weeks of age. However, LP2+gly group recorded the lowest BW at 12 weeks of age, while recorded significantly better relative weights of carcass, liver, gizzard and spleen. Results also showed no significant differences in shank and keel length, goblet cell number, villi height, crypt depth, blood total antioxidant capacity, glutathione and all blood biochemical parameters. Glycine supplemented groups recorded significantly higher growth hormone values and lower litter moisture and litter nitrogen values. In conclusion adding glycine 0.2% to low protein diet (1.5% reduction) improve growth performance and litter quality of Mandarah local Egyptian strain during starter and grower periods.