Miracle-dz/UniFAR-FTUs huggingface dataset:
Effectiveness of Online and Remote Interventions for Mental Health in Children, Adolescents, and Young Adults After the Onset of the COVID-19 Pandemic: Systematic Review and Meta-Analysis

Background The prevalence of mental illness increased in children, adolescents, and young adults during the COVID-19 pandemic, while at the same time, access to treatment facilities has been restricted, resulting in a need for the quick implementation of remote or online interventions. Objective This study aimed to give an overview of randomized controlled studies examining remote or online interventions for mental health in children, adolescents, and young adults and to explore the overall effectiveness of these interventions regarding different symptoms. Methods A systematic literature search was conducted according to PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analysis) guidelines using PubMed, PsycInfo, Psyndex, Embase, and Google Scholar. A meta-analysis was conducted using a random effects model to calculate overall effect sizes for interventions using standardized mean differences (SMDs) for postintervention scores. Results We identified 17 articles with 8732 participants in the final sample, and 13 were included in the quantitative analysis. The studies examined different digital interventions for several outcomes, showing better outcomes than the control in some studies. Meta-analyses revealed significant medium overall effects for anxiety (SMD=0.44, 95% CI 0.20 to 0.67) and social functioning (SMD=0.42, 95% CI –0.68 to –0.17) and a large significant effect for depression (SMD=1.31, 95% CI 0.34 to 2.95). In contrast, no significant overall treatment effects for well-being, psychological distress, disordered eating, and COVID-19–related symptoms were found. Conclusions The qualitative and quantitative analyses of the included studies show promising results regarding the effectiveness of online interventions, especially for symptoms of anxiety and depression and for training of social functioning. However, the effectiveness needs to be further investigated for other groups of symptoms in the future. All in all, more research with high-quality studies is required.
An Analysis of Daily Maximum Wind Speed in Northwestern Europe Using Generalized Linear Models

Abstract The basic climatological pattern and recent trends in daily maximum wind speed (DMWS) for the region 47.5°–65°N and 12.5°W–22.5°E are studied using gamma distributions within a generalized linear model. Between 1958 and 1998, DMWS has increased over the ocean in winter but weakened over continental Europe in summer. Large-scale circulation changes such as those of the North Atlantic Oscillation (NAO) and Arctic Oscillation (AO) account for the strengthening wind over the ocean. Global warming may have impacted the regional wind climate. In particular, Southern Hemisphere temperature exhibits a significant effect on the distinct oceanic and continental trends in DMWS. It is suggested that the steady warming of the Southern Hemisphere during the last few decades may have forced the North Atlantic storm track to shift in such a way that storms are enhanced toward the northwestern oceanic area, but weakened throughout most of the European continent.
Null model analyses are not adequate to summarize strong associations: Rebuttal to Ulrich et al. (2022)

We recently developed a novel metric of association in pairwise co-occurrence data (Mainali et al., 2022) to address fundamental flaws in traditional indices, as elaborately discussed and conclusively shown in our published paper. Our new metric, the maximum likelihood estimator (MLE) alpha-hat of a statistical parameter alpha, quantifies the degree of association between species occupancy at ecological sites, and it is insensitive to the species prevalences and number of sites. In contrast, we showed that classic indices of co-occurrence (Jaccard, Simpson, Sørensen–Dice) can be highly sensitive to fixed margins of 2 × 2 contingency tables, estimating wildly variable degrees of association and even reversing the direction of association for tables with different margins but the same degree-of-association alpha. Ulrich et al. (2022), hereafter USSG, adversely commented on our paper, claiming that our metric lacked novelty and insights beyond null-hypothesis standardization techniques. In this commentary, we address each of USSG's specific claims reflecting their view that test statistics for null association adequately summarize strongly non-null association in co-occurrence data. We show that standardized co-occurrence behaves differently in different data-sets
Racializing Area Studies, Defetishizing China

Abstract:Area studies was originally set up to provide strategically important information for the US empire, while ethnic studies was an aftermath of the civil rights movement critiques it from within. This alone may explain the hostility between area studies and ethnic studies, but the crucial pivot around which this hostility can be better understood is the question of race. What happens when we racialize area studies—that is, to investigate the racial unconscious of area studies—where the “area” as such has been turned into a fetish, with its attendant racial, gender, and libidinal politics? Reading select Sinophone literary texts as allegories of area studies, in this case the Sinitic script as the fetish object, further illuminates the imperative to defetishize the area and bring race squarely into area studies.
The Impact of Poverty and Human Development Index on Inequality of Income Distribution of Regency/City in North Sumatra

This research aims to analyze the impact of poverty and the Human Development Index (HDI) on inequality of income distribution of regency/city in North Sumatra province. This research is quantitative descriptive. The research was conducted in 33 regencies/cities in North Sumatra province. The type of data used is secondary data. Data is accessed online on the website of Central Statistical Agency (BPS) for North Sumatra Province. The data used includes poverty rate data, HDI and Gini Ratio. Data analysis used multiple linear regression analysis. The results showed that poverty had a positive and significant impact on inequality of income distribution of regency/city in North Sumatra province. HDI also has a positive and significant impact on inequality of income distribution of regency/city in North Sumatra province. The results of the simultaneous test conclude that poverty and HDI simultaneously have a significant impact on inequality of income distribution of regency/city in North Sumatra province. This research implicates on preparation of poverty alleviation programs and equal of income distribution of regency/city in North Sumatra province.
Difficult-to-Treat Rejections in Kidney Transplant Recipients: Our Experience with Everolimus-Based Quadruple Maintenance Therapy

All chronic and treatment-resistant acute rejections are “difficult-to-treat” and lead to progressive loss of graft function in kidney transplant recipients (KTR), as no effective treatment exists for such rejections to date. We review our experience with a novel strategy to treat such rejections by adding everolimus as a “rescue” to conventional triple maintenance therapy with prednisolone, mycophenolate mofetil and calcineurin inhibitor. We retrospectively analysed data in 28 KTR who received everolimus-based quadruple therapy at our institution for biopsy-proven chronic active T cell-mediated or antibody-mediated rejection (n = 19) or treatment-resistant acute rejections (n = 9) between 2011–2017. The primary outcome was 5-year death-censored graft survival. Main secondary outcomes were response to treatment defined by stable or improved graft function, 5-year patient survival and discontinuation rate of treatment. The Kaplan–Meier estimate for 5-year death-censored graft survival was 79% in all patients, 90% for patients with chronic active T cell-mediated rejections, 78% for chronic active antibody-mediated rejection and 67% for acute rejections. Response to treatment was achieved in 43% and 5-year patient survival was 94%. Treatment was stopped in 12 (43%) patients due to adverse events. Everolimus-based maintenance quadruple therapy, despite high rate of everolimus discontinuation due to adverse events, may be a valid approach in a subset of kidney transplant recipients with such difficult-to-treat rejections, which otherwise would lead to a high rate of graft loss.
Exploring family farm development in dryland agricultural areas: A case study of the Laghouat region of Algeria

Family farming is the predominant agricultural system of dryland agriculture in Algeria. TheNational Agricultural and Rural Development Program (PNDAR) was implemented in the last decade to enhance the development of family farms in drylands. The objective of the present study was to explore family farm development in Algerian dryland agricultural areas. Specifically, we were interested in the behavior of farmers and stockbreeders toward various institutional and agricultural development policies. To this end, surveys were conducted on 35 randomly selected stratified farmers using closed structured questionnaires in 5 municipalities, which were used to represent the three bioclimatic zones in the Laghouat prefecture. The results showed that the main form of organization at family farms depends on the bioclimatic zone, which affects the production systems, public support and conservative adaptation strategies. Constraints related to production factors are widespread, affect farm operations and challenge public policy. Agricultural diversification such as the introduction of livestock farming and non-agricultural activities occurred on the majority of the farms, and two primary strategies for achieving food securitywere observed. Namely, food crops were prioritized and diversified on family farms, andspeculative crops and livestock were raised simultaneously. Nevertheless, the acquisition of subsidies and farming intensification did not yield significant results due to the non-continuity of actions in time and space. The results of the present study indicated that family farm development policies in drylands should be adaptable and account for the heterogeneity of agriculture, especially bioclimatic factors. Key words: Family farm, dryland, agricultural policy, agricultural development, bioclimatic.
Safety and Efficacy of Hypoxia-Inducible Factor-Prolyl Hydroxylase Inhibitors vs. Erythropoietin-Stimulating Agents in Treating Anemia in Renal Patients (With or Without Dialysis): A Meta-Analysis and Systematic Review

Hypoxia-inducible factor-prolyl hydroxylase domain inhibitors (HIF-PHIs) are a novel group of drugs used to treat renal anemia, but their benefits vary among different trials. Our meta-analysis aims to assess the safety and efficacy of HIF-PHI versus erythropoiesis-stimulating agents (ESA) in managing anemia among patients with chronic kidney disease (CKD), regardless of their dialysis status. PubMed, Embase, and Google Scholar were queried to discover eligible randomized controlled trials (RCTs). To quantify the specific effects of HIF-PHI, we estimated pooled mean differences (MDs) and relative risks (RR) with 95% CIs. Our meta-analysis involved 22,151 CKD patients, with 11,234 receiving HIF-PHI and 10,917 receiving ESA from 19 different RCTs. The HIF-PHI used included roxadustat, daprodustat, and vadadustat. HIF-PHI yielded a slight but significant increase in change in mean hemoglobin (Hb) levels (MD: 0.06, 95% CI (0.00, 0.11); p = 0.03), with the maximum significant increase shown in roxadustat followed by daprodustat as compared to ESA. There was a significant decrease in efficacy outcomes such as change in mean iron (MD: -1.54, 95% CI (-3.01, -0.06); p = 0.04), change in mean hepcidin (MD: -21.04, 95% CI (-28.92, -13.17); p < 0.00001), change in mean ferritin (MD: -16.45, 95% CI (-27.17,-5.73); p = 0.03) with roxadustat showing maximum efficacy followed by daprodustat. As for safety, HIF-PHI showed significantly increased incidence in safety outcomes such as diarrhea (MD: 1.3, 95% CI (1.11, 1.51); p = 0.001), adverse events leading to withdrawal (MD: 2.03, 95% CI (1.5, 2.74), p = 0.00001) among 25 various analyzed outcomes. This meta-analysis indicates that HIF-PHIs present a potentially safer and more effective alternative to ESAs, with increased Hb levels and decreased iron usage in CKD patients without significantly increasing adverse events. Therefore, in these patients, we propose HIF-PHI alongside renal anemia treatment.
PTPN13 Participates in the Regulation of Epithelial–Mesenchymal Transition and Platinum Sensitivity in High-Grade Serous Ovarian Carcinoma Cells

Epithelial ovarian cancer (EOC) is the leading cause of death from gynecological cancers in Western countries. High-Grade Serous Ovarian Carcinoma (HGSOC) accounts for 60–70% of EOC and is the most aggressive subtype. Reduced PTPN13 expression levels have been previously correlated with worse prognosis in HGSOC. However, PTPN13’s exact role and mechanism of action in these tumors remained to be investigated. To elucidate PTPN13’s role in HGSOC aggressiveness, we used isogenic PTPN13-overexpressing clones of the OVCAR-8 cell line, which poorly expresses PTPN13, and also PTPN13 CRISPR/Cas9-mediated knockout/knockdown clones of the KURAMOCHI cell line, which strongly expresses PTPN13. We investigated their migratory and invasive capacity using a wound healing assay, their mesenchymal-epithelial transition (EMT) status using microscopy and RT-qPCR, and their sensitivity to chemotherapeutic drugs used for HGSOC. We found that (i) PTPN13 knockout/knockdown increased migration and invasion in KURAMOCHI cells that also displayed a more mesenchymal phenotype and increased expression of the SLUG, SNAIL, ZEB-1, and ZEB-2 EMT master genes; and (ii) PTPN13 expression increased the platinum sensitivity of HGSOC cells. These results suggest that PTPN13 might be a predictive marker of response to platinum salts in HGSOC.
Dress Like Me: An Exploration of Rural Graduate Social Work Attire

During graduate school internship training, some students wear more formal attire and others casual attire. This study’s purpose was to explore rural areas clients’ preference for graduate social work interns’ attire. Clients from internship sites located in a rural southern location were asked their attire preferences based on comfort and confidence levels, degree of warmth, returning appointments
Effects of different irrigation methods on grain yield and yield components of hybrid maize (Zea mays L. indentata S.).

This study was conducted at Bahri Dagdas International Agricultural Research Institute’s research fields in between 2005 and 2006 years in Konya Province. It was used that split split plots in randomized complete blocks experimental design with three replications. In the research, the different irrigation systems (drip and furrow irrigation), three maize varieties from different maturation stage (DK-585, OSSK-602 and P-31G98), the different plant densities 70x24 cm (59520 plants/ha), 70x20 cm (71420 plants/ha), 70x18 cm (79360 plants/ha), 70x16 cm (89280 plants/ha) were randomizedly applied to main plots, sub plots and sub sub plots, respectively. * Bu calisma S.U. BAP (Proje No: 05201013) tarafindan desteklenen doktora tez projesinin bir bolumunu icermektedir.
An In Vitro Study regarding the Wear of Composite Materials Following the Use of Dental Bleaching Protocols

Composite materials used in dental restorations are considered resistant, long-lasting and aesthetic. As the wear of restorations is an important element in long-term use, the aim of this study was to evaluate the surface condition of nanohybrid and microfilled composite resins, after being subjected to the erosive action of dental bleaching protocols. This paper reflects a comparative study between one nanofilled composite and three microfilled composites used in restorations. For each composite, three sets of samples (under the form of composite discs) were created: a control group, an “office bleach” group with discs bleached with 40% hydrogen peroxide gel, and a “home bleach” group with discs bleached with 16% carbamide peroxide gel. Wear was numerically determined as the trace and the coefficients of friction obtained using a tribometer, the ball-on-disk test method, and two balls: alumina and sapphire. For all composite groups, there were statistically significant differences between the wear corresponding to the control and bleaching groups, for both testing balls. Regarding the composite type, the largest traces were recorded for GC Gradia direct anterior, for all groups, using the alumina ball. In contrast, for the sapphire ball, 3M ESPE Filtek Z550 was characterized by the largest traces. With respect to the friction coefficients, the “office bleach” group recorded the largest values, no matter the composite or the ball type used. The 3M ESPE Valux Plus composite recorded the largest friction coefficients for the alumina ball, and 3M ESPE Filtek Z550 for the sapphire ball. Overall, the “office bleach” group was characterized by higher composite wear, compared to the “home bleach” protocol or control group. Nanofilled composite resins showed superior wear resistance to microfilled resins after undergoing a bleaching protocol.
Developing a learning environment based on science, technology, engineering, and mathematics for pre-service teachers of early childhood teacher education

The purpose of this research is to describe the development of a STEM-based learning environment for early childhood teacher candidates that is valid, practical, and has potential effects. The research sample consisted of 25 pre-service early childhood teachers and 19 students Kindergarten. The research method used was design research with the type of development study. This research has produced a learning environment with the Campus-Application-School (CAS) model consisting of the stages of training, designing, mentoring, and testing. The validity of the STEM-based learning environment model was seen from the developed student worksheet (LKPD) instrument and the content in the learning environment, obtaining a value of 0.88, which was categorized as high validity. The practicality, as seen from the results of one-to-one teaching, small group, and field tests with an average of 94.2, was categorized as very good. Meanwhile, the potential effect was based on Kirkpatrick's four levels of training evaluation with an average of 83.73, which was categorized as very good. This research suggests that the CAS learning environment model can affect teacher approaches to teaching in a step appropriate way based on STEM to prepare student teachers to teach basic mathematics.
Function of Cytochrome P450s and Gut Microbiome in Biopesticide Adaptation of Grapholita molesta on Different Host Diets

Insects that feed on various host plants possess diverse xenobiotic adaptations; however, the underlying mechanisms are poorly understood. In the present study, we used Grapholita molesta, which shifts feeding sites from peach shoots to apple fruits, as a model to explore the effects of shifts in host plant diet on the profiles of cytochrome P450s and the gut bacteria microbiome, as well as their effects on biopesticide adaptation. We found that the sensitivity of the fruit-feeding G. molesta to emamectin benzoate biopesticide was significantly lower than that of the shoot-feeding larvae. We also found that the P450 enzyme activity and the expression of nine cytochrome P450s were enhanced in G. molesta fed on Fuji apples compared to those fed on peach shoots. The survival rates of G. molesta exposed to emamectin benzoate significantly decreased as each of three of four emamectin benzoate-inducted cytochrome P450 genes were silenced. Furthermore, we discovered the gut bacteria dynamics of G. molesta changed with the host shift and the structure of the gut bacteria microbiome was determined by the final diet ingested; additionally, the dysbiosis of the gut microbiota induced by antibiotics could significantly increase the sensitivity to emamectin benzoate. Taken together, our results suggest that the expression of P450s and the composition of the gut bacteria microbiome promote adaptation to emamectin benzoate in G. molesta, providing new insights into the molecular mechanisms underlying xenobiotic adaptation in this notorious pest.
The Past, Present, and Future of Wheat Dwarf Virus Management—A Review

Wheat dwarf disease (WDD) is an important disease of monocotyledonous species, including economically important cereals. The causative pathogen, wheat dwarf virus (WDV), is persistently transmitted mainly by the leafhopper Psammotettix alienus and can lead to high yield losses. Due to climate change, the periods of vector activity increased, and the vectors have spread to new habitats, leading to an increased importance of WDV in large parts of Europe. In the light of integrated pest management, cultivation practices and the use of resistant/tolerant host plants are currently the only effective methods to control WDV. However, knowledge of the pathosystem and epidemiology of WDD is limited, and the few known sources of genetic tolerance indicate that further research is needed. Considering the economic importance of WDD and its likely increasing relevance in the coming decades, this study provides a comprehensive compilation of knowledge on the most important aspects with information on the causal virus, its vector, symptoms, host range, and control strategies. In addition, the current status of genetic and breeding efforts to control and manage this disease in wheat will be discussed, as this is crucial to effectively manage the disease under changing environmental conditions and minimize impending yield losses.
Experiment Investigation of the Compression Behaviors of Nickel-Coated Hybrid Lattice Structure with Enhanced Mechanical Properties

The lattice metamaterial has attracted extensive attention due to its excellent specific strength, energy absorption capacity, and strong designability of the cell structure. This paper aims to explore the functional nickel plating on the basis of biomimetic-designed lattice structures, in order to achieve higher stiffness, strength, and energy absorption characteristics. Two typical structures, the body-centered cubic (BCC) lattice and the bioinspired hierarchical circular lattice (HCirC), were considered. The BCC and HCirC lattice templates were prepared based on DLP (digital light processing) 3D printing. Based on this, chemical plating, as well as the composite plating of chemical plating followed by electroplating, was carried out to prepare the corresponding nickel-plated lattice structures. The mechanical properties and deformation failure mechanisms of the resin-based lattice, chemically plated lattice, and composite electroplated lattice structures were studied by using compression experiments. The results show that the metal coating can significantly improve the mechanical properties and energy absorption capacity of microlattices. For example, for the HCirC structure with the loading direction along the x-axis, the specific strength, specific stiffness, and specific energy absorption after composite electroplating increased by 546.9%, 120.7%, and 2113.8%, respectively. The shell–core structure formed through composite electroplating is the main factor for improving the mechanical properties of the lattice metamaterial. In addition, the functional nickel plating based on biomimetic structure design can further enhance the improvement space of mechanical performance. The research in this paper provides insights for exploring lighter and stronger lattice metamaterials and their multifunctional applications.