Miracle-dz/UniFAR-FTUs huggingface dataset:
A Randomized Controlled Trial of the Treatment of Rotator Cuff Tears with Bone Marrow Concentrate and Platelet Products Compared to Exercise Therapy: A Midterm Analysis

Injectable regenerative therapies such as bone marrow concentrate (BMC) and platelet-rich plasma (PRP) may represent a safe alternative in the treatment of rotator cuff tears. This is a midterm review of a randomized, crossover trial comparing autologous BMC and platelet product injections versus exercise therapy in the treatment of partial and full-thickness supraspinatus tears. Patients enrolled into the study were between 18 and 65 years of age presenting to an outpatient orthopedic clinic with partial to full thickness, nonretracted supraspinatus tendon tears. Enrolled patients were randomized to either ultrasound-guided autologous BMC with PRP and platelet lysate (PL) percutaneous injection treatment or exercise therapy. Patients could cross over to BMC treatment after at least 3 months of exercise therapy. Patients completed the Disability of the Arm, Shoulder and Hand (DASH) scores as the primary outcome measure. Secondary outcomes included the numeric pain scale (NPS), a modified Single Assessment Numeric Evaluation (SANE), and a blinded MRI review. At this midterm review, results from 25 enrolled patients who have reached at least 12-month follow-up are presented. No serious adverse events were reported. Significant differences were seen in patient reported outcomes for the BMC treatment compared to exercise therapy at 3 and 6 months for pain, and for function and reported improvement (SANE) at 3 months (p < .05). Patients reported a mean 89% improvement at 24 months, with sustained functional gains and pain reduction. MRI review showed a size decrease of most tears post-BMC treatment. These findings suggest that ultrasound-guided BMC and platelet product injections are a safe and useful alternative to conservative exercise therapy of torn, nonretracted supraspinatus tendons. This trial is registered with NCT01788683.
HIF-1 alpha expression as a predictor of bevacizumab efficacy in metastatic colorectal cancer.

601 Background: Assome controversies exist regarding the efficacy of bevacizumab (B) for the treatment of metastatic colorectal cancer (mCRC), novel predictive biomarkers are needed to improve patient selection and optimize the use of this agent. We analyzed the potential usefulness of five circulating biomarkers as predictors of B efficacy and in monitoring the disease. Methods: Peripheral blood samples collected at different times (baseline, first clinical evaluation and disease progression) were available for 62 of the 376 patients enrolled in the prospective multicentric ITACa trial (NCT01878422) and randomized to receive FOLFOX4/FOLFIRI (CT) with or without B. Thirty-one of the 62 patients received CT plus B and31 received CT only (control group). All patients were evaluated for response according to RECIST criteria. mRNA was isolated and used for gene expression analysis of HIF-1α, COX2, VEGF-A, EPHB4 and eNOS by a quantitative RT-PCR method. Baseline expression levels of the markers and their modul.
EXAMINING RELATIONSHIPS BETWEEN FAMILY MEALTIME ROUTINES AND FEEDING OUTCOMES IN YOUNG CHILDREN WITH SENSORY FOOD AVERSIONS

Picky eating is a common behavior of early childhood. Young children with Sensory Food Aversions (SFA) are at increased risk for picky eating behaviors that persist throughout childhood and into adulthood. Interventions that support increased dietary variety in the home are needed to prevent nutritional deficiency and related health issues later in life. The focus of this dissertation was to develop and test the feasibility and preliminary effects of an intervention, embedded within daily family meals, to improve feeding outcomes in young children with SFA. First, we conducted a hierarchical logistic regression to determine if frequency of family meals predicted low fruit and vegetable consumption in a large sample of preschool-age children. Next, we evaluated the feasibility and preliminary effects of the Mealtime PREP intervention for eleven children with SFA and their parents. Our findings support that the established protective benefits of family meals for school-age children and adolescents generalize to young children as well. We learned that low frequency of family meals is predictive of low fruit and vegetable intake among preschoolers. Additionally, we determined that the Mealtime PREP intervention package is feasible to deliver in the home and acceptable to parents of children with SFA. Preliminary analyses of effects suggest that statistically significant changes in food acceptance and clinically relevant shifts in mealtime behavior and risk of nutritional deficiency were observed in 9 of 11 child participants after parents were trained to deliver intervention strategies during scheduled, daily family meals. Valuable insights gained from this project will be incorporated into future studies examining the effects of the Mealtime PREP intervention. Future studies should focus on the development of an effective, yet parsimonious, protocol to promote healthy dietary variety in young children. Larger scale studies are required to make inferences about the effects of this type of intervention in the population of young children who are picky eaters. Future work is also needed to parse out the effects of parent-mediated interventions using a behavioral activation approach to parent-training. This method shows promise to bridge the gap of intervention delivery between the clinic and the home environment.
Comparative Analysis of the Science Teaching Curricula in Turkey

The purpose of this study is to comparatively investigate the science teaching curricula in Turkey, which have undergone changes four times since the millennium. For this purpose, we carried out a technical and taxonomic examination of the learning outcomes listed in the science curricula that were introduced in 2000, 2005, 2013, and 2017 concerning Revised Bloom Taxonomy (RBT). In this study, the document analysis method was used. We classified a total of 2,613 learning outcomes in our analyses, which were limited to those related to the cognitive domain. The reliability score of the classifications was . 89 according to the equation proposed by Miles and Huberman. The analyses showed that the teaching curricula decreased the intensity of the focus on knowledge and cognitive skills rather than making fundamental changes. Moreover, there was significant parallelism among the examined curricula in terms of the dimensions of the taxonomy. Using national-level results in international exams such as PISA (Programme for International Student Assessment) and TIMSS (Trends in International Mathematics and Science Study), we concluded that Turkey had not been successful enough in developing the examined curricula.
A novel authentication and key‐agreement scheme for satellite communication network

In these days, satellite communication networks are playing a significant role in facilitating the crucial infrastructural services that include environmental monitoring, electronic surveillance, public safety, intelligence operations for law enforcement, government agencies, and the military. However, security researchers have uncovered that many protocols for these satellite communication networks have some vulnerabilities and flaws that can allow remote attackers to intercept, block, and manipulate critical communication over the network. Therefore, in this article, we introduce an efficient and simple authentication key agreement protocol for securing mobile satellite communication systems. Our proposed protocol resists against denial of service, smart‐card stolen, replay, user impersonation, and stolen verifier attack. Furthermore, our protocol provides various functionality features like perfect‐forward secrecy, mutual‐authentication, dynamic identity, and session‐key agreement. Moreover, the performance analysis of our protocol shows that the communication and computation cost of the proposed protocol is far less than the existing protocols. Hence, our proposed protocol offers simple, efficient, secure authentication, and key agreement for mobile satellite systems.
Observer Design for Nonlinear Systems With Output Transformation

This article addresses the problem of robust observer design for nonlinear systems with transformed output. We first assume that there exists an observer design for a given nonlinear system. The structure of the system output is often crucial for estimating the system states. Therefore, we consider the problem that arises when the output is only available under a nonlinear transformation (affected by noise). This formulation is especially useful in engineering applications, where nonlinear sensors are frequent. We propose a new interconnected observer that estimates both the unavailable output and the system states, and we establish small-gain type conditions ensuring the asymptotic convergence of the overall error dynamics. To explicit our design parameters, we study the particular cases of state-affine systems up to output injection and systems with additive triangular nonlinearities. Finally, we provide corresponding numerical examples and comparisons with known observers.
Data protection on hadoop distributed file system by using encryption algorithms: a systematic literature review

Big data has capability to process huge amount of unstructured and structured data. Nowadays, technology is able to support business need by extracting massive amount of data and recognizing its pattern to predict future trends. It brings right insight in business strategy to gain tremendous benefit. Hadoop is a reliable technology which developed to distribute process and storage on big data efficiently. However, Hadoop doesn’t have any built-in provision to encrypt data by default. Hadoop additional feature in encryption zone has security issue which key management does outside of HDFS. Sensitive and confidential data in HDFS can be exposed against security attack. Information security is fundamental concern and new set challenge for the world of big data. The main purpose of this paper is to protect Hadoop Distributed File System data by using encryption algorithm. This is to ensure data is secured at storage level of HDFS. Dealing with big data, it is important to choose fast enough encryption algorithm that has great performance. Research methodology is SLR (System Literature Review) by using methodology of PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses).
A GIS method to identify flat surfaces and restore relict fluvial long‐profiles from terrace remnants gives new clues on how large basins respond to endorheic–exorheic transitions (Duero basin, Iberian Peninsula)

Fluvial terraces are used as geomorphic indicators for deciphering long‐term landscape evolution. Knowing the distribution of fluvial terraces is essential for establishing former river profiles and their tectonic significance, for studying climate‐modulated processes of terrace development, or for defining fluvial network adjustments in response to sudden base‐level changes like those produced by fluvial captures. Multiple methods for automatic map production have been proposed based on the comparison of morphometric indices with those of the modern river course. Here we propose an alternative method to identify flat surfaces and scarps separating them from digital elevation models without setting comparisons with a modern river course and thus fully applicable to study flat landforms whatever their origin. Its application to the low‐relief landscape of the Cenozoic Duero basin has allowed the improvement of previous geomorphological maps and the analysis of fluvial network adjustments in response to a sudden base‐level fall after the opening of the Neogene endorheic basin towards the Atlantic Ocean. Reconstructed terrace long‐profiles suggest an initial episode of fast vertical incision followed by a period of repeated planation–aggradation–incision with the formation of 14 to 13 unpaired terrace levels. Changes observed in the pattern of terrace profiles are discussed with regard to changes in regional tectonics and base‐level variations. © 2019 John Wiley & Sons, Ltd.
Valor prognóstico da variabilidade da frequência cardíaca e da eletrocardiografia ambulatorial em cães Boxer com cardiomiopatia arritmogênica do ventrículo direito

Arrhythmogenic right ventricular cardiomyopathy (ARVC) is an important cause of sudden death in Boxer dogs. Validation of prognostic factors for this disease could help in detecting more severely affected animals and their exclusion from breeding programs. The aims of this study were to evaluate the prognostic significance of presence of symptoms, heart rate variability (HRV) indices and ventricular or supraventricular arrhythmias recorded by Holter monitoring on survival of Boxer dogs with ARVC at different stages. Symptoms, arrhythmias registered on Holter and five HRV indices were prospectively analyzed in 69 client-owned Boxer dogs divided into five groups: control Boxer dogs (CB group, 300 VPC/24 hours, n=19), Boxers with ARVC and systolic dysfunction without congestive heart failure (SDB without CHF group, n=6) and with CHF (SDB with CHF group, n=8). Statistical analyses consisted of an ANOVA test, Pearson correlation and Cox's proportional hazards regression. Compared to the CB group, no decrease in HRV indices was found in SB, ARVCB or SDB without CHF groups; otherwise, SDB with CHF group had impaired indices. No relation was found between HRV indices and cardiac-related death, but the presence of syncopes with or without clinical signs of heart failure and number of ventricular tachycardia (VT), were correlated with survival. These results allow us to conclude that the presence of symptoms of heart failure, presence of syncopes and number of VT on Holter examination seem to have prognostic value in Boxer ARVC.
Clinical characteristics and prognostic factors of malignant fibrous histiocytoma of bone: a SEER population-based study

Background Malignant fibrous histiocytoma of bone (MFH-B) is an extremely rare type of bone tumor. We aimed to analyze the clinical characteristics of MFH-B and establish nomograms that predict the prognosis of patients with MFH-B based on prognostic factors. Methods A total of 250 patients diagnosed with MFH-B were included from the Surveillance, Epidemiology, and End Results (SEER) database. Kaplan-Meier curves and log-rank tests were conducted. Potential prognostic factors were identified using univariate and multivariate Cox regression analysis. Nomograms that predict 3- and 5-year overall survival (OS) and cancer-specific survival (CSS) were further developed and internally validated. Results The multivariate analysis suggested that OS of patients was associated with age ≥57 years [hazard ratio (HR), 1.916; 95% confidence interval (CI), 1.329–2.761; P<0.001], pelvic bones (HR, 1.742; 95% CI, 1.024–2.961; P=0.040) and other tumor sites (HR, 2.498; 95% CI, 1.515–4.120; P<0.001), Grade III/IV (HR, 1.750; 95% CI, 1.002–3.056; P=0.049), distant tumor stage (HR, 2.100; 95% CI, 1.351–3.263; P=0.001), tumor size ≥66 mm (HR, 2.629; 95% CI, 1.747–3.959; P<0.001) and no surgery (HR, 2.134; 95% CI, 1.380–3.300; P=0.001). We then developed nomograms based on the prognostic factors. The concordance index (C-index) of nomograms for OS and CSS were 0.74 (95% CI, 0.70–0.77) and 0.74 (95% CI, 0.70–0.78). Calibration plots suggested optimal concordance between the predictive outcomes of nomograms with the actual survival. Conclusions This is the first sizable study that analyzed clinical characteristics and prognostic factors of MFH-B. The nomograms we established for MFH-B were effective tools to predict prognosis of individual patients. These tools can also help doctors identify mortality risk.
A Framework to Predict Consumption Sustainability Levels of Individuals

Innovative Information Systems services have the potential to promote more sustainable behavior. For these so-called Green Information Systems (Green IS) to work well, they should be tailored to individual behavior and attitudes. Although various theoretical models already exist, there is currently no technological solution that automatically estimates individual’s current sustainability levels related to their consumption behaviors in various consumption domains (e.g., mobility and housing). The paper aims at addressing this gap and presents the design of GREENPREDICT, a framework that enables to predict these levels based on multiple features, such as demographic, socio-economic, psychological, and factual knowledge about energy information. To do so, the paper presents and evaluates six different classifiers to predict acts of consumption on the Swiss Household Energy Demand Survey (SHEDS) dataset containing survey answers of 2000 representative individuals living in Switzerland. The results highlight that the ensemble prediction models (i.e., random forests and gradient boosting trees) and the multinomial logistic regression model are the most accurate for the mobility and housing prediction tasks.
Ecosystem Service Response to Human Disturbance in the Yangtze River Economic Belt: A Case of Western Hunan, China

Ecosystem conservation is one of the core elements of sustainable development. Studying the relationship between human disturbance and the ecosystem service value (ESV) change is an urgent need for the future. The Yangtze River Economic Belt is one of the key economic strategies implemented by the Chinese government and is also a demonstration zone for ecological conservation. Western Hunan is an important ecological barrier in the Yangtze basin where different ethnic groups live together and various cultures coexist. In this study, using land-use data and spatial analysis modeling, the changes in the ecosystem service value at five topographic gradients were evaluated. Human disturbance and its spatial correlation with the ecosystem service value from 1990 to 2015 were also investigated. The results demonstrated the following: (1) the proportional area of forestland and grassland increased as the topographic gradient index increased and other types of land-use gradually decreased; (2) The ecosystem service value at middle gradients increased over the study period; but ESV of the lowest topographic gradient showed a significant decline and a substantial decrease, as well as a terrain index under 0.7970; (3) The spatial analysis of human disturbance showed that more than 90% of intense human disturbance was distributed in the area of the lowest topographic gradient where topographic features were low-altitude and low-slope, and little human disturbance was scattered at other gradients; (4) There was a significant spatial aggregation distribution between the ecosystem service value and human disturbance in western Hunan, the high disturbance and low ESV aggregation was mainly distributed in Loudi City, the area east of Shaoyang City and Zhangjiajie City all belonged to the lowest topographic gradient, and the low–high and high–high aggregations were mainly distributed in Huaihua City and Xiangxi Tujia and Miao Autonomous Prefecture. Population density and gross domestic product were the main driving factors, while topography was the main ecological factor. This study could provide additional spatial information and theoretical guidance for ecosystem service management for sustainable development in western Hunan, China.
Somatostatin Receptor Imaging In Recurrent Medullary Thyroid Cancer

This study was performed to evaluate the clinical value of somatostatin receptor scintigraphy (SRS) in the diagnostic management of patients having recurrent medullary thyroid cancer (MTC). In 22 patients with recurrent MTC after primary surgical intervention, 33 SRS were performed. Planar imaging was carried after i.v. administration of 180 MBq of [In]-DTPA-D-Phe-octreotide (Octreoscan®), SPET of the neck and thoracic regions. The scintigraphical results were compared with the tumor markers human calcitonin (hCT), CEA, other imaging methods, histological findings, and clinical follow-up. In 36% (8/22) of the cases, SRS was concordant to the defined gold standard in the detection or exclusion of tumor tissue. If patients with liver metastases are excluded, SRS was positive in hCT levels >6.4 ng/ml and in hCT/CEA ratios >0.38. SRS can only be recommended to clear up equivocal findings especially in patients having sufficiently elevated titers of hCT levels and hCT/CEA ratios.
Risks For Individualization In The Context Of Socio-Psychological Safety Of Schools

Transformation of the sociocultural environment has a direct impact on the educational environment. It also provokes risks connected with the socio-psychological safety of the modern educational space. Within the framework of the considered problem is an insufficient study of the ratio of external to internal determinants of socio-psychological safety of the educational environment. It is important to consider the role of risks for individualization in the context of assessing the socio-psychological safety of schools. The theoretical part of the study is based on the principles of system-structural methodology. Individualization is defined as one of the core processes (along with formation, modernization and integration) within the author’s procedural-morphological model of the educational environment. This process implements the function of activating the personality in the educational space. The carrier of this process is a social block. The main risk of individualization is social apathy. The empirical part of the study is based on the cross-section method. Statistical methods: nonlinear correlation analysis, multiple regression analysis. The study comprised a sample of 186,000 students of middle schools aged from 13 till 16 years. The empirical data was analysed in relation to 45 territorial units of the Republic of Tatarstan. The procedural morphological model of the educational environment has conceptual viability and allows considering risks for individualization as problems of individual activation with insufficient sustainability of the social block of the educational environment. 2357-1330 © 2020 Published by European Publisher.
Younger Millennials and Outdoor Recreation: Understanding Outdoor Recreational Pursuits of Millennial College Students

YOUNGER MILLENNIALS AND OUTDOOR RECREATION: UNDERSTANDING OUTDOOR RECREATIONAL PURSUITS OF MILLENNIAL COLLEGE STUDENTS JASON MEHLHAF 2019 Outdoor recreation has been shown through past research to provide numerous benefits to the participant when utilized, but for younger millennials, life’s expectations are pulling them away from participating. If there is a decrease in recreation participation, what will motivate this demographic toward participation in the future? The purpose of this study is to identify younger millennial perceptions, habits, and trends, so that in the future, recreation professionals are able to cater for specifically toward this demographic. Two universities in South Dakota, one public and one private, were surveyed through an online software program, QuestionPro, to a convenience sample from both schools. Younger millennials were specifically targeted by focusing on college students, who are between the ages of 19-24, to narrow the sample down to those on the younger end of the generation. The results of descriptive analysis found that the respondents like to recreate with others and prefer leisure recreation (walking, recreation with pets, lawn games) to active recreation. The study also found a positive correlation between length of time recreating and respondent comfort levels, as well as a positive correlation between structural constraints and respondents desire to enjoy nature. The respondents are more interested in programs that cater toward their interests instead of programs focused on history or culture. Future recreation professionals could use the information found in this study to create recreation programs that encourage group participation, cater toward