Miracle-dz/UniFAR-FTUs huggingface dataset:
Effect of the Ongoing Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Pandemic on Dental Service Utilization in Patients With Comorbidities

Background: The keystone of safe and effective patient management is to approach a patient with up-to-date medical information. Assessment of patients for their medical conditions has changed during the coronavirus disease 2019 (COVID-19) pandemic and the need for appropriate research infrastructure has increased. Considering an updated list of high-risk underlying conditions in the post-COVID-19 era, this study aimed to evaluate the utilization of dental services by patients with comorbidities during the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. Methods: Data of patients with comorbidities seeking dental care at a dental school during the COVID-19 pandemic were retrospectively evaluated. Demographic variables (age, gender) and medical history of the participants were recorded. The patients were classified according to their diagnosis. Data were analyzed using descriptive statistics and Chi-square analysis. The significance level was determined at α=0.05. Results: The study included data from 1067 patient visits between September 1, 2020 and November 1, 2021. Among these patients, 406 (38.1%) were males and 661 (61.9%) were females, with a mean age of 38.28 ± 14.36 years. Comorbidities were identified in 38.3% of the patients with predominance in females (74.1% n=303). Single comorbidity was observed in 28.1% while multi-morbidity was detected in 10.2% of the cohort. The most prevalent comorbidity was hypertension (9.7%), followed by diabetes (6.5%), thyroid disorders (5%), various psychological diseases (4.5%), COVID-19 infection (4.5%), and different allergies (4%). The presence of one or more co-morbidities was observed mostly in the 50-59 years age group. Conclusions: The seeking of dental care among the adult population with comorbidities was high during the SARS-CoV-2 pandemic. It would be beneficial to develop a template for obtaining a medical history from patients by taking full account of the consequences of the pandemic. The dental profession needs to respond accordingly.
The Moderating Role of Entrepreneurial Self-Efficacy and Locus of Control on the Effect of the University Environment and Program on Entrepreneurial Intention and Attitudes

This article examines the influence of the university environment and learning programs on students' entrepreneurial intentions and attitudes, considering the moderating roles of entrepreneurial self-efficacy and locus of control. The empirical analysis employs a multilevel (hierarchical) linear model, utilizing responses from 713 students across 30 universities in Kazakhstan who participated in the GUESSS 2021 project survey. Our findings reveal that students' entrepreneurial intentions are directly influenced by entrepreneurial self-efficacy and locus of control. However, the locus of control is also indirectly influenced by the university environment and learning program. The learning program's effect on both entrepreneurial aspirations and attitudes is mediated by self-efficacy. Locus of control, conversely, negatively affects both entrepreneurial attitudes and intentions in program learning. The study's results underscore that student entrepreneurship is shaped by personal factors such as self-efficacy and locus of control, alongside the university context. Interestingly, the findings also indicate interdependencies between these factors, further influencing students' entrepreneurial intentions and attitudes.
Determinant Employee Productivity and Organization Sustainability: Analysis Performance Appraisals, Evaluation Performance, Competence Employee and Motivation

The purpose of this study is to measure organizational sustainability with several constructs that are considered supporters, including performance appraisals, performance evaluations, employee competence, and motivation. The research method of this article uses a literature review study, Literature Study is a way to solve problems by tracing the sources of writing that have been made before. The novelty of this article is the framework formed from the reference to previous international journal articles, findings of significance, and insignificance between variables. The gap in this study is described in a complete research result description and supported by previous articles
Predictions of the Ejected Water Mass from Shallow Depth Explosion Plumes

Abstract A study is presented showing results of predictions of the amount of water ejected from shallow depth explosions. Measurements of the Equivalent Water Length (EWL) are determined by integrating the density along a horizontal line through the plume. These EWL values are important for the assessment of the viability of using plumes as an effective water barrier for vessel defense. The predictions are obtained using a model based on a generalized formulation of hydrodynamics using an incompressible liquid assumption. This formulation is well suited for predicting long-time bubble and plume dynamics and has been previously validated on a variety of applications including water plume predictions. The purpose of this study is to obtain estimates for EWL values at specified heights, the time length that these levels persist during the plume evolution, as well as estimates for the effects of charge depth and size.
Satellite-Derived Latent Heating Distribution and Environmental Influences in Hurricane Opal (1995)

Abstract The total (i.e., convective and stratiform) latent heat release (LHR) cycle in the eyewall region of Hurricane Opal (October 1995) has been estimated using observations from the F-10, F-11, and F-13 Defense Meteorological Satellite Program Special Sensor Microwave/Imagers (SSM/Is). This LHR cycle occurred during the hurricane’s rapid intensification and decay stages (3–5 October 1995). The satellite observations revealed that there were at least two major episodes in which a period of elevated total LHR (i.e., convective burst) occurred in the eyewall region. During these convective bursts, Opal’s minimum pressure decreased by 50 mb and the LHR generated by convective processes increased, as greater amounts of latent heating occurred at middle and upper levels. It is hypothesized that the abundant release of latent heat in Opal’s middle- and upper-tropospheric region during these convective burst episodes allowed Opal’s eyewall to become more buoyant, enhanced the generation of kinetic energy and.
On the structure of balanced and other principal representations of SISO systems

A new matrix W co which can be considered as a cross-Gramian matrix which contains information about both controllability and observability is defined for single-input, single-output, linear systems. Using this matrix, the structural properties of linear systems are studied in the context of principal component analysis. The matrix W co can be used in obtaining balanced and other principal representations without computation of the controllability and the observability Gramians. The importance of this matrix in model-order reduction is highlighted.
Memes and its impact on strengthening students’ critical reading skills

This article reports a study that aimed to determine the level of impact of a didactic strategy mediated by memes to strengthen critical reading skills in elementary school students. We worked with 38 sixth grade students belonging to a Colombian educational institution. The research was carried out under a mixed approach, where the quantitative approach allowed to establish the variation of the student’s performance through a pre and post-test. The qualitative approach was used to characterize the students’ reading habits, to identify the type of memes they use on social networks, and to know their perception of the didactic strategy. The results show that the didactic strategy mediated by memes strengthened the students’ critical reading skills since there was a high learning gain of 0.859.
Indefinite Determiner Doubling

Both formal and functional analyses of nominals have to acknowledge that in terms of word order, it is not enough to observe that in nominals, determiners precede the noun. After considering (1) below, the temptation is to call all, the and many ‘determiners’. However, the fact that sentences like (2) are perfectly fine but, as (3) shows, many must occupy the first slot following the determiner in adjectival order has led to it being classified as a ‘postdeterminer’, giving three general areas preceding the noun in a traditional Quirk grammar approach
BORTEM-17: A phase IB/II single arm, multicentre study investigating the efficacy of sequential bortezomib and temozolomide in recurrent GBM with unmethylated MGMT promoter—The results of an interim analysis.

2019 Background: Glioblastoma (GBM) is the most frequent, lethal primary brain tumor in adults. Patients harboring tumors with functional O6 methylguanine DNA methyltransferase ( MGMT) DNA enzyme gain limited benefit from temozolomide therapy. As shown in preclinical studies, bortezomib depletes the MGMT enzyme, restoring the tumor ́s susceptibility to temozolomide, if administered in a precise schedule when the MGMT enzyme is depleted. We hypothesized that recurrent GBM patients with unmethylated MGMT promoter may obtain clinical benefit from sequential BTZ and TMZ treatment. Methods: BORTEM-17 is a multicenter, open label, single arm, non-randomized phase IB/II trial to investigate potential survival benefit for recurrent glioblastoma patients administered bortezomib 48hrs prior to temozolomide. Sample size is calculated to 63 patients, of whom 10 included in phase IB. The doses of bortezomib is 1.3mg/m2 intravenously days 1, 4, and 7 during 4-week cycle, and temozolomide 200mg/m2 days 5-7. The control group is a retrospective cohort of 467 patients treated at 2 referral hospitals in Norway from January 2015 to December 2017. For the survival analysis, the patients included in BORTEM-17 (n=44) were compared with MGMT unmethylated control, age matched patients (n=116). The pre-defined interim analysis was performed after inclusion of 15 patients and as more than 2 of 15 patients had clinical benefit, the study was continued. Results: Until January 2023, 44 patients with median age 55 years (range 25-69), 30 males and 14 females were treated. Median KPS was 90 (70-100) and median NANO score 1 (0-7). The interim analysis was performed after inclusion of 15 patients in the phase IB and II and clinical benefit was observed in 5 patients. Two of them had tumor volume reduction and three experienced stable disease. The study proceeded to the next step. No treatment related deaths were observed. The most common adverse effects included hematological toxicity, gastrointestinal symptoms, muscle weakness, lower back pain and fatigue. Patients that progressed during the BORTEM-17 trial and were fit for further therapy received treatment at their physician’s discretion. The preliminary data analysis after 44 of planned 63 patients were treated indicate prolonged median survival for BORTEM-17 patients 19.0 months vs 12.2 months of control MGMT unmethylated age matched patients. Median survival after recruitment is 5.5 months (1.0-23.8). Conclusions: The sequential BTZ+TMZ therapy is safe, feasible and effective as indicated by preliminary data when 70% of planned MGMT unmethylated patients have been included. Preliminary data indicate that the combination of BTZ and TMZ may offer an additional line of treatment with limited toxicity to the group of patients with particularly dismal prognosis. Clinical trial information: NCT03643549 .
The Effect of Bilingual-Word-List versus Semantic Network Practices on EFL Lexical Competence

role of semantic network practices on the depth of vocabulary knowledge than bilingual word lists. The comparisons of the mean scores of synonyms and collocations of WAT post-test in experimental groups indicated that class A (an experimental group who received sematic network practices) significantly outperformed class B (an experimental group who received bilingual word lists) in collocations. Conclusion: The study concluded that the FL learners’ mastery of new vocabulary knowledge is possible through obtaining a deep understanding of the acquired words.
Assessment of Stress Level and Quality of Life in Spinal Cord Injury Patients

Background: Spinal cord injury (SCI) involves severe physical, social, and also psychological consequences, and cause severe disturbance in normal daily activities of a person. Aim: To assess the stress level and quality of life (QOL) variation among spinal cord injured individuals. Study design: Descriptive Cross sectional. Methodology: Simple random sampling recruited 165 participants (15-75 years) both genders, from government and public hospitals of Lahore and Islamabad. Data was collected by using The “Perceived Stress Scale (PSS-14 item)”and “WHOQOL-BREF” (26-item). Data SPSS v.24 analyzed the data. Quantitative data was expressed in terms of frequency and percentages. Results were shown in tabular and graph forms. Results: On PSS questionnaires 87.9% experience moderate stress, 12.1% experience severe stress. On WHOQOL-Bref the average score of physical health was 53.18, psychological health was 55.42, social relationship was 69.16 and the lowest most score among four domains was environmental health 52.73. Practical Impact: This study provided information regarding the perceived level of stress and QOL in SCI patients that is the most ignorant portion of our society and recognized the importance of assessing variation of stress and QOL in these patients so health care team take appropriate decisions for the improvement of the health status of these client. Conclusion: It was concluded that SCI patients had moderate stress level and face life threatening complication associated with this injury. Thus, both physical disability and psychological disturbance may adversely impact their stress level and quality of life. Keywords: Stress, Quality of life, Spinal cord injury and Psychological Impact.
Population age and household structures shape transmission dynamics of emerging infectious diseases: a longitudinal microsimulation approach

Host population demographics and patterns of host-to-host interactions are important drivers of heterogeneity in infectious disease transmission. To improve our understanding of how population structures and changes therein influence disease transmission dynamics at the individual and population level, we model a dynamic age- and household-structured population using longitudinal microdata drawn from Belgian census and population registers. At different points in time, we simulate the spread of a close-contact infectious disease and vary the age profiles of infectiousness and susceptibility to reflect specific infections (e.g. influenza and SARS-CoV-2) using a two-level mixing model, which distinguishes between exposure to infection in the household and exposure in the community. We find that the strong relationship between age and household structures, in combination with social mixing patterns and epidemiological parameters, shape the spread of an emerging infection. Disease transmission in the adult population in particular is to a large degree explained by differential household compositions and not just household size. Moreover, we highlight how demographic processes alter population structures in an ageing population and how these in turn affect disease transmission dynamics across population groups.
How could a pooled testing policy have performed in managing the early stages of the COVID-19 pandemic? Results from a simulation study

A coordinated testing policy is an essential tool for responding to emerging epidemics, as was seen with COVID-19. However, it is very difficult to agree on the best policy when there are multiple conflicting objectives. A key objective is minimising cost, which is why pooled testing (a method that involves pooling samples taken from multiple individuals and analysing this with a single diagnostic test) has been suggested. In this paper, we present results from an extensive and realistic simulation study comparing testing policies based on individually testing subjects with symptoms (a policy resembling the UK strategy at the start of the COVID-19 pandemic), individually testing subjects at random or pools of subjects randomly combined and tested. To compare these testing methods, a dynamic model compromised of a relationship network and an extended SEIR model is used. In contrast to most existing literature, testing capacity is considered as fixed and limited rather than unbounded. This paper then explores the impact of the proportion of symptomatic infections on the expected performance of testing policies. Only for less than 50% of infections being symptomatic does pooled testing outperform symptomatic testing in terms of metrics such as total infections and length of epidemic. Additionally, we present the novel feature for testing of non-compliance and perform a sensitivity analysis for different compliance assumptions. Our results suggest for the pooled testing scheme to be superior to testing symptomatic people individually, only a small proportion of the population (>2%) needs to not comply with the testing procedure.
Adding Different Exercise Training Volumes to a Diet-Induced Weight Loss Facilitates Fat Loss and Maintains Fat-Free Mass in a Dose-Depending Fashion in Persons with Newly Diagnosed Type 2 Diabetes: Secondary Findings from the DOSE-EX Multi-Arm, Parallel-Group, Randomized Trial

OBJECTIVE - To assess the dose-response effects of exercise in combination with a diet-induced weight loss on fat mass (FM) percentage (FM%) in persons with diagnosed type 2 diabetes. RESEARCH DESIGN AND METHODS - In this secondary analysis of a four-armed randomized trial (Clinicaltrials.gov NCT03769883) 82 persons (35% females, mean age and standard deviation (SD) 58.2 (9.8) years) living with type 2 diabetes were randomly allocated to the control group (N=21, CON), diet control (25% energy restriction; N=20, DCON), diet control and exercise three times/week (two sessions of aerobic and one session combining resistance and aerobic training; N=20, MED), or diet control and exercise six times/week (four sessions of aerobic and two sessions combining resistance and aerobic training; N=21, HED) for 16 weeks. The primary outcome was the change in FM percentage points (pp). Secondary outcomes included fat-free mass and visceral adipose tissue volume. RESULTS- Type 2 diabetes duration was 4.0 years (interquartile range 1.9 to 5.5), body weight (SD) 101.4 kg (14.6), FM% (SD) 39.4 (6.7). FMpp decreased compared to standard care -3.5 pp (95% CI -5.6 to -1.4) p=0.002, -6.3 pp (CI -8.4 to -4.1) p<0.001, and -8.0 pp (95% CI -10.2 to -5.8) p<0.001, for DCON, MED, and HED, respectively. The difference between HED and MED was -1.8 pp [95% CI -3.9 to 0.4]; p=0.11). CONCLUSIONS- All interventions were superior in reducing FMpp compared to standard care in a dose-dependent manner. Adding three or six sessions of exercise to a low-calorie diet was superior in reducing FM compared to a low-calorie diet alone.
Relationship between understanding of gender and LGBTQ and brain health with a focus on the triple network

Various studies have been conducted mainly in the fields of social sciences to address the lack of understanding of diversity in Japan regarding gender, LGBTQ, etc., but little progress has been made in promoting diversity in society. In this study, we aimed to clarify the specific brain states of people who have a high understanding of diversity (gender and LGBTQ) using the gray matter brain healthcare quotient (GM-BHQ), a brain health index obtained by MRI image analysis, and the results of a psychological questionnaire on diversity. As a result of the analysis, the GM-BHQ of the Central Executive Network (CEN) tended to be significantly higher than the estimated values from age, gender, and BMI in the group with a high understanding of gender equality. GM-BHQ of the Salience Network (SN) also tended to be relatively high. In addition, the GM-BHQ of SN, default mode network (DMN), and CEN, as well as whole brain GM-BHQ were significantly higher among those with a high understanding of LGBTQ than the estimated values. These results suggest that understanding diversity requires a healthy brain centered on the triple network that governs rational judgment, emotional adjustment, recognition of others, self-recognition, and value judgment of behavior.
Discriminating the HTM and MLRSM models in collider studies via doubly charged Higgs boson pair production and the subsequent leptonic decays

We present a case study for the doubly charged Higgs boson pair production in and pp colliders with their subsequent decays to four charged leptons. We consider the Higgs Triplet Model ( ), which is not restricted by the custodial symmetry, and the Minimal Left-Right Symmetric Model ( ). These models include scalar triplets with different complexities of scalar potentials and, because of experimental restrictions, completely different scales of non-standard triplet vacuum expectation values. In both models, a doubly charged Higgs boson can acquire a mass of hundreds of gigaelectronvolts, which can be probed at the HL-LHC, future , and hadron colliders. We take into account a comprehensive set of constraints on the parameters of both models coming from neutrino oscillations, LHC, , and low-energy lepton flavor violating data and assume the same mass of . Our finding is that the pair production in lepton and hadron colliders is comparable in both models, though more pronounced in the . We show that the decay branching ratios can be different within both models, leading to distinguishable four-lepton signals, and that the strongest are events yielded by the . Typically, we find that the signals are one order of magnitude larger those in the . For example, the signal for 1 TeV mass results in a clearly detectable significance of for the HL-LHC and for the FCC-hh. Finally, we provide quantitative predictions for the dilepton invariant mass distributions and lepton separations, which help to identify non-standard signals.
Standardization of weightage assigned to different segments of the hand X-ray for assessment of bone age by the Greulich Pyle method

Abstract: Objectives: Bone age (BA) assessment is important in evaluating disorders of growth and puberty; the Greulich and Pyle atlas method (GP) is most used. We aimed to determine the weightage to be attributed by raters to various segments of the hand x-ray, namely, distal end of radius-ulna (RU), carpals, and short bones for rating bone age using the GP atlas method. Methods: 692 deidentified x-rays from a previous study (PUNE-dataset) and 400 from the Radiological Society of North America (RSNA-dataset) were included in the study. Mean of BA assessed by experienced raters was termed reference rating. Linear regression was used to model reference age as function of age ratings of the three segments. The root-mean-square-error (RMSE) of segmental arithmetic mean and weighted mean with respect to reference rating were computed for both datasets. Results: Short bones were assigned the highest weightage. Carpals were assigned higher weightage in pre-pubertal PUNE participants as compared to RSNA, vice-versa in RU segment of post-pubertal participants. The RMSE of weighted mean ratings was significantly lower than for the arithmetic mean in the PUNE dataset. Conclusion: We thus determined weightage to be attributed by raters to segments of the hand x-ray for assessment of bone age by the GP method.