Miracle-dz/UniFAR-FTUs huggingface dataset:
Particle Acceleration in Mildly Relativistic Shearing Flows: The Interplay of Systematic and Stochastic Effects, and the Origin of the Extended High-energy Emission in AGN Jets

The origin of the extended X-ray emission in the large-scale jets of active galactic nuclei (AGNs) poses challenges to conventional models of acceleration and emission. Although electron synchrotron radiation is considered the most feasible radiation mechanism, the formation of the continuous large-scale X-ray structure remains an open issue. As astrophysical jets are expected to exhibit some turbulence and shearing motion, we here investigate the potential of shearing flows to facilitate an extended acceleration of particles and evaluate its impact on the resultant particle distribution. Our treatment incorporates systematic shear and stochastic second-order Fermi effects. We show that for typical parameters applicable to large-scale AGN jets, stochastic second-order Fermi acceleration, which always accompanies shear particle acceleration, can play an important role in facilitating the whole process of particle energization. We study the time-dependent evolution of the resultant particle distribution in the presence of second-order Fermi acceleration, shear acceleration, and synchrotron losses using a simple Fokker–Planck approach and provide illustrations for the possible emergence of a complex (multicomponent) particle energy distribution with different spectral branches. We present examples for typical parameters applicable to large-scale AGN jets, indicating the relevance of the underlying processes for understanding the extended X-ray emission and the origin of ultrahigh-energy cosmic rays.
Differences in Prognostic Factors among Patients Hospitalized for Heart Failure According to the Age Category: From the KUNIUMI Registry Acute Cohort

Objective Previous studies have described several prognostic factors for heart failure (HF); however, these results were derived from registries consisting of conventional age groups, which might not represent the increasingly aging society. The present study explored the prognostic factors for all-cause death in hospitalized patients with HF across different age categories using an acute HF registry that included relatively old patients. Methods From a total of 1,971 consecutive patients with HF, 1,136 patients were enrolled. We divided the patients into 4 groups (≤65, 66-75, 76-85, and >85 years old) to evaluate all-cause death and prognostic factors of all-cause death. Results During the mean follow-up period of 1,038 days, 445 patients (39.2%) had all-cause death. A Kaplan-Meier analysis demonstrated significantly higher incidence of all-cause death in the elderly groups than in the younger groups (log-rank p<0.001). A Cox proportional-hazard regression analysis revealed that the presence of atrial fibrillation [hazard ratio (HR): 23.3, 95% confidence interval (CI): 2.36-231.1, p=0.007] was a notable predictive factor for all-cause death in the ≤65 years old group, whereas the Clinical Frailty Scale score (HR: 1.33, 95% CI: 1.16-1.52, p<0.001) and hypoalbuminemia (HR: 0.49, 95% CI: 0.31-0.78, p=0.003) were predictors in the >85 years old group. Conclusions Atrial fibrillation was a notable predictor of HF in young patients, whereas frailty and low-grade albuminemia were essential predictive factors of HF in elderly patients. With the increasing number of elderly patients with HF, comprehensive multidisciplinary treatment will be necessary.
Interstellar Neutral Helium in the Heliosphere from IBEX Observations. V. Observations in IBEX-Lo ESA Steps 1, 2, and 3

Direct-sampling observations of interstellar neutral (ISN) He by the Interstellar Boundary Explorer (IBEX) provide valuable insight into the physical state of and processes operating in the interstellar medium ahead of the heliosphere. The ISN He atom signals are observed at the four lowest ESA steps of the IBEX-Lo sensor. The observed signal is a mixture of the primary and secondary components of ISN He and H. Previously, only data from one of the ESA steps have been used. Here, we extend the analysis to data collected in the three lowest ESA steps with the strongest ISN He signal, for the observation seasons 2009–2015. The instrument sensitivity is modeled as a linear function of the atom impact speed onto the sensor’s conversion surface separately for each ESA step of the instrument. We find that the sensitivity increases from lower to higher ESA steps, but within each of the ESA steps it is a decreasing function of the atom impact speed. This result may be influenced by the hydrogen contribution, which was not included in the adopted model, but seems to exist in the signal. We conclude that the currently accepted temperature of ISN He and velocity of the Sun through the interstellar medium do not need a revision, and we sketch a plan of further data analysis aiming at investigating ISN H and a better understanding of the population of ISN He originating in the outer heliosheath.
Galactic Panspermia

We present an analytic model to estimate the total number of rocky or icy objects that could be captured by planetary systems within the Milky Way Galaxy and result in panspermia should they harbor life. We estimate the capture rate of objects ejected from planetary systems over the entire phase space as well as time. Our final expression for the capture rate depends upon the velocity dispersion as well as the characteristic biological survival time and the size of the captured object. We further take into account the number of stars that an interstellar object traverses, as well as the scale height and length of the Milky Way’s disk. The likelihood of Galactic panspermia is strongly dependent upon the survival lifetime of the putative organisms as well as the velocity of the transporter. Velocities between 10–100 km s−1 result in the highest probabilities. However, given large enough survival lifetimes, even hypervelocity objects traveling at over 1000 km s−1 have a significant chance of capture, thereby increasing the likelihood of panspermia. Thus, we show that panspermia is not exclusively relegated to solar system-sized scales, and the entire Milky Way could potentially be exchanging biotic components across vast distances.
Quantum correlations in composite systems

We study emerging notions of quantum correlations in compound systems. Based on different definitions of quantumness in individual subsystems, we investigate how they extend to the joint description of a composite system. Especially, we study the bipartite case and the connection of two typically applied and distinctively different concepts of nonclassicality in quantum optics and quantum information. Our investigation includes the representation of correlated states in terms of quasiprobability matrices, a comparative study of joint and conditional quantum correlations, and an entanglement characterization. It is, for example, shown that our composition approach always includes entanglement as one form of quantum correlations. Yet, other forms of quantum correlations can also occur without entanglement. Finally, we give an outlook towards multimode systems and temporal correlations.
External validation of a heart failure risk score in patients with acute myeloid leukemia

Abstract A 21-point risk score for heart failure (HF) has been developed for patients with acute myeloid leukemia (AML), stratifying patients into three groups: low, moderate, and high-risk. In this study, 193 patients with AML treated with anthracycline-based therapy were stratified using the risk score, and its prognostic utility for HF events and all-cause mortality at one year of follow-up were evaluated. HF occurred in 18% (34/193) of anthracycline-treated patients. Global longitudinal strain (GLS) was more negative among patients without HF events (−19 ± 3 vs. −17 ± 4%). One year incidence of HF was increased in the higher risk groups: 12% of low-risk, 24% of moderate-risk, and 50% of high-risk (p < 0.001). However, a higher risk score was not associated with an increased risk of all-cause mortality. This study provides external validation of a 21-point risk score for HF events but not all-cause mortality at one year in patients with AML.
Tunable Third-Harmonic Generation from Polaritons in the Ultrastrong Coupling Regime

Strong interparticle interactions between polaritons have traditionally stemmed from their exciton component. In this work, we impart a strong third-order nonlinearity to a polaritonic mode by embedding a nonlinear polymethine dye within a high-Q all-metal microcavity. We demonstrate nonlinear microcavities operating in the ultrastrong coupling regime with a normalized coupling ratio of 62%, the highest reported to date. When pumping the lower polariton branch, we observe tunable third-harmonic generation spanning the entire visible spectrum, with internal conversion enhancements more than 3 orders of magnitude larger than in bare films. Transfer matrix calculations indicate that the observed enhancements are consistent with the enhanced pump electric field.
Relieving the tension between weak lensing and cosmic microwave background with interacting dark matter and dark energy models

We constrain interacting dark matter and dark energy (IDMDE) models using a 450-degree-square cosmic shear data from the Kilo Degree Survey (KiDS) and the angular power spectra from Planck's latest cosmic microwave background measurements. We revisit the discordance problem in the standard Lambda cold dark matter (ΛCDM) model between weak lensing and Planck datasets and extend the discussion by introducing interacting dark sectors. The IDMDE models are found to be able to alleviate the discordance between KiDS and Planck as previously inferred from the ΛCDM model, and moderately favored by a combination of the two datasets.
Hot Molecular Gas in the Circumnuclear Disk

We present an analysis of archival Infrared Space Observatory observations of H2 for three pointings in the central 3 pc of the Galaxy: toward the southwest region and northeast region of the Galactic center circumnuclear disk (CND), and toward the supermassive black hole Sgr A*. We detect pure rotational lines from 0–0 S(0) to S(13), as well as a number of rovibrationally excited transitions. Using the pure rotational lines, we perform both fits to a discrete temperature distribution (measuring up to three temperature components with T = 500–600 K, T = 1250–1350 K, and T > 2600 K) and fits to a continuous temperature distribution, assuming a power-law distribution of temperatures. We measure power-law indices of n = 3.22 for the northeast region and n = 2.83 for the southwest region. These indices are lower than those measured for other galaxies or other Galactic center clouds, indicating a larger fraction of gas at high temperatures. We also test whether extrapolating this temperature distribution can yield a reasonable estimate of the total molecular mass, as has been recently done for H2 observations in other galaxies. Extrapolating to a cutoff temperature of 50 K in the southwest (northeast) region, we would measure 32% (140%) of the total molecular gas mass inferred from the dust emission, and 26% (125%) of the total molecular gas mass inferred from the CO emission. Ultimately, the inconsistency of the masses inferred in this way suggests that a simple application of this method cannot yield a reliable estimate of the mass of the CND.
Modelling inner ear development and disease using pluripotent stem cells – a pathway to new therapeutic strategies

ABSTRACT The sensory epithelia of the mammalian inner ear enable sound and movement to be perceived. Damage to these epithelia can cause irreversible sensorineural hearing loss and vestibular dysfunction because they lack regenerative capacity. The human inner ear cannot be biopsied without causing permanent damage, significantly limiting the tissue samples available for research. Investigating disease pathology and therapeutic developments have therefore traditionally relied on animal models, which often cannot completely recapitulate the human otic systems. These challenges are now being partly addressed using induced pluripotent stem cell-derived cultures, which generate the sensory epithelial-like tissues of the inner ear. Here, we review how pluripotent stem cells have been used to produce two-dimensional and three-dimensional otic cultures, the strengths and limitations of these new approaches, and how they have been employed to investigate genetic and acquired forms of audiovestibular dysfunction. This Review provides an overview of the progress in pluripotent stem cell-derived otic cultures thus far, focusing on their applications in disease modelling and therapeutic trials. We survey their current limitations and future directions, highlighting their prospective utility for high-throughput drug screening and developing personalised medicine approaches.
An Incipient Debris Disk in the Chamaeleon I Cloud

The point at which a protoplanetary disk becomes a debris disk is difficult to identify. To better understand this, here we study the ∼40 au separation binary T 54 in the Chamaeleon I cloud. We derive a K5 spectral type for T 54 A (which dominates the emission of the system) and an age of ∼2 Myr. However, the dust disk properties of T 54 are consistent with those of debris disks seen around older- and earlier-type stars. At the same time, T 54 has evidence of gas remaining in the disk, as indicated by [Ne ii], [Ne iii], and [O i] line detections. We model the spectral energy distribution of T 54 and estimate that of small dust grains (<0.25 μm) are present in an optically thin circumbinary disk along with at least of larger (>10 μm) grains within a circumprimary disk. Assuming a solar-like mixture, we use Ne line luminosities to place a minimum limit on the gas mass of the disk ) and derive a gas-to-dust mass ratio of ∼0.1. We do not detect substantial accretion, but we do see Hα in emission in one epoch, which is suggestive that there may be intermittent dumping of small amounts of matter onto the star. Considering the low dust mass, the presence of gas, and young age of T 54, we conclude that this system is on the bridge between the protoplanetary and debris disk stages.
Early detection of external cervical resorption in posterior teeth: a radiographic, cross-sectional study of an adolescent population

Objectives: To establish the prevalence and severity of external cervical resorption (ECR) in posterior teeth observed in bitewing (BW) radiographs in an epidemiological study of a 17-year-old patient population from community dentistry. Furthermore, to assess the potential predisposing factors for ECR. Methods: Posterior BWs from 5596 patients (2717 females, 2879 males; mean age 17.8 years) were assessed by three observers in order to detect ECR (using Heithersay’s classification system, severity classes 1–4). When ECR was suspected, cone beam CT (CBCT) was offered to verify diagnosis. Prevalence was estimated based on ECR suspected in BWs and finally in CBCT. Possible predisposing factors (orthodontic treatment, trauma, and periodontal disease) were recorded and assessed for association with ECR. Results: In 41 patients, ECR was suspected in BWs (suspected prevalence 0.73%). 32 patients accepted CBCT examination, of which eight were verified to have ECR (final prevalence 0.18%). In 24 patients, other disease entities and abnormal tooth morphology, that had mimicked ECR in BWs, excluded ECR in CBCT. ECR severity ranged from class 1–3 in BW and 2–4 in CBCT. All but one case had not been diagnosed by the patient’s community dentist. No statistically significant association between predisposing factors and ECR was identified. Conclusions: ECR had low prevalence in this adolescent population, as observed in both BWs and CBCT. Still, early detection of ECR is important for treatment prognosis, and attention should be paid to this disease entity when assessing BWs obtained for other diagnostic purposes. CBCT may subsequently aid in verifying the disease.
The nature of submillimetre and highly star-forming galaxies in the EAGLE simulation

We exploit EAGLE, a cosmological hydrodynamical simulation, to reproduce the selection of the observed submillimetre (submm) galaxy population by selecting the model galaxies at z ≥ 1 with mock submm fluxes $S_{850\, \mu \mathrm{m}}$ ≥ 1 mJy. We find a reasonable agreement between the model galaxies within this sample and the properties of the observed submm population, such as their star formation rates (SFRs) at z < 3, redshift distribution, and many integrated galaxy properties. We find that the median redshift of the $S_{850\, \mu \mathrm{m}}$ ≥ 1 mJy model population is z ≈ 2.5, and that they are massive galaxies (M* ∼ 1011 M⊙) with high dust masses (Mdust ∼ 108 M⊙), gas fractions (fgas ≈ 50 per cent), and SFRs ($\dot{M}_* \approx 100$ M⊙ yr−1). In addition, we find that they have major and minor merger fractions similar to the general population, suggesting that mergers are not the sole driver of the high SFRs in the model submm galaxies. Instead, the $S_{850\, \mu \mathrm{m}}$ ≥ 1 mJy model galaxies yield high SFRs primarily because they maintain a significant gas reservoir as a result of hosting an undermassive black hole relative to comparably massive galaxies. Not all ‘highly star-forming’ ($\dot{M}_* \ge 80$ M⊙ yr−1) eagle galaxies have submm fluxes $S_{850\, \mu \mathrm{m}}$ ≥ 1 mJy. We investigate the nature of these highly star-forming ‘Submm-Faint’ galaxies (i.e. $\dot{M}_* \ge 80$ M⊙ yr−1 but $S_{850\, \mu \mathrm{m}}$ < 1 mJy) and find that they are similar to the model submm galaxies, being gas rich and hosting undermassive black holes. However, they are also typically at higher redshifts (z > 4) and are lower mass (M* ∼ 1010 M⊙). These typically higher redshift galaxies show stronger evidence for having been triggered by major mergers, and critically, they are likely missed by most current submm surveys due to their higher dust temperatures and lower dust masses.
Anisotropy in the distribution of satellites around primary galaxies in the 2dF Galaxy Redshift Survey: the Holmberg effect

We have analysed a sample of satellite and primary galaxies in the 2dF Galaxy Redshift Survey. In our study we find strong statistical evidence of the Holmberg effect (that is, a tendency for satellites to avoid regions along the line defined by the primary plane) within 500 kpc of the projected distance to the primary. This effect is present only when we restrict our analysis to objects with radial velocity relative to the primary |Δν| < 160 km s -1 , which corresponds approximately to the mean of the distribution. We explore the dependence of this anisotropy on spectral type (η), colours and luminosities of both primaries and satellites, finding that objects with a low present-day star formation rate present the most significant effect.
Hybrid quantum systems based on magnonics

Engineered quantum systems enabling novel capabilities for computation and sensing have blossomed in the last decade. Architectures benefiting from combining complementary physical systems have emerged as promising approaches for quantum technologies. A new class of hybrid quantum systems based on collective spin excitations in ferromagnetic materials has led to the diverse set of platforms outlined in this review article. The coherent interaction between microwave cavity modes and spin-wave modes is presented as a key ingredient for the development of more complex hybrid systems. Indeed, quanta of excitation of the spin-wave modes, called magnons, can also interact coherently with optical photons, phonons, and superconducting qubits in the fields of cavity optomagnonics, cavity magnomechanics, and quantum magnonics, respectively. Notably, quantum optics experiments in magnetically-ordered solid-state systems are within reach thanks to quantum magnonics. Applications of hybrid quantum systems based on magnonics for quantum information processing and quantum sensing are briefly outlined.
Technology-Based Obesity Prevention Interventions Among Hispanic Adolescents in the United States: Scoping Review

Background Given that today’s adolescents are digital front-runners, technology-based obesity prevention strategies are age-appropriate for this population. The use of remote and wireless technologies may be suitable for extending the reach and engagement of obesity prevention efforts among high-risk Hispanic youths, as this subgroup is disproportionately affected by barriers that limit participation in traditional, in-person interventions. Objective The purpose of this scoping review was to examine the intervention and sample characteristics of technology-based obesity prevention interventions among Hispanic adolescents. We also examined feasibility criteria to assess the acceptability and appropriateness of technology-based strategies among Hispanic youths. Methods A comprehensive search of Embase and PubMed identified 7 studies that met the inclusion criteria. Data were extracted by 2 independent reviewers. Results Of the 7 included studies, half (n=4, 57%) used a randomized control trial design, with equal implementation in school (n=3, 43%) and clinic (n=4, 57%) settings. Studies commonly targeted improvements in diet (n=4, 57%) and physical activity (n=7, 100%), with only 1 (14%) study focused on sedentary behaviors. Just 2 (29%) studies reported the use of behavioral theories or models. Studies focused primarily on youths in early (n=5, 71%) or middle (n=6, 86%) adolescence, and there was limited information reported on socioeconomic status. Only 3 (43%) study conducted formative work, and few (n=3, 43%) reported on acceptability. Only 1 (14%) study reported that materials were available in Spanish and English, and only 1 (14%) study used culturally tailored content. Additionally, 3 (43%) studies used strategies that considered social determinants of health. Conclusions To increase our understanding of the feasibility and effectiveness of technology-based obesity prevention strategies among Hispanic adolescents, there is a need for more feasibility studies that are theoretically grounded and comprehensively report on feasibility-related outcomes. Future studies should also leverage technology to simultaneously address multiple health behaviors beyond diet and physical activity. The result of this review can be used to guide the development of future technology-based obesity prevention strategies among Hispanic adolescents. Trial Registration CliniclaTrials.gov NCT04953442; https://clinicaltrials.gov/ct2/show/NCT04953442