Miracle-dz/UniFAR-FTUs huggingface dataset:
‘One internship, two internships, three internships … more!’: exploring the culture of the multiple internship economy

ABSTRACT Internships are increasingly promoted as a high impact practice to improve students’ post-graduation employment outcomes, and educators often encourage students to participate in multiple internships. Yet, there is a lack of research on the sociocultural contexts associated with multiple internship participation. We present findings about the culture of multiple internship participation – drawing on focus groups and one-year follow-up interviews with students at five colleges in the United States, along with interviews with their educators and an analysis of online documents about multiple internship participation. The evidence documents a particular culture of the multiple internship economy, representing multiple internships as a linear, progressive, goal-oriented cultural project to accumulate a marketable self; also described by anthropologists as a neoliberal conception of the self. This cultural conception of a marketable neoliberal self is comprised of signs – such as narratives of multiple internships – that provide evidence of skills and experiences, of persevering through obstacles, and of ‘hustle’ and a ‘do what it takes’ attitude, which can be deployed to navigate competitive gatekeeping encounters such as employment interviews. Based on these findings, we develop a sociocultural theory of multiple internship participation as a project of neoliberal gatekeeping navigation.
Experimental Investigation on the Seismic FRP Retrofit of Realistic Full-Scale RC Beam-Column Joints

The results of four cyclic tests on full-scale beam-column joints with typical pre-1970s deficiencies are presented. The challenges incurred by the presence of a floor slab and transverse beams in retrofitting deficient specimens are often ignored, but are here fully taken into account in the experimental set-up. A realistic repair and retrofit scheme using carbon fibre-reinforced polymer (CFRP) sheets is proposed. The scheme aims to improve the ductility of the deficient joints, while providing continuity of the flexural strengthening through the joint. The results highlight that the proposed retrofit can successfully increase the ductility of the joint by activating the beams. The presence of the slab has a significant effect on the global behaviour of the sub-assembly, which ultimately does not reach failure in the beams due to the stiff slab limiting rotation. Despite significant pre-damage, the repair scheme is very efficient, with only minor differences in terms of initial stiffness and lateral strength compared to the retrofit.
Late Triassic to Jurassic Magmatic and Tectonic Evolution of the Intermontane Terranes in Yukon, Northern Canadian Cordillera: Transition From Arc to Syn‐Collisional Magmatism and Post‐Collisional Lithospheric Delamination

End‐on arc collision and onset of the northern Cordilleran orogen is recorded in Late Triassic to Jurassic plutons in the Intermontane terranes of Yukon, and in development of the synorogenic Whitehorse trough (WT). A synthesis of the extensive data set for these plutons supports interpretation of the magmatic and tectonic evolution of the northern Intermontane terranes. Late Triassic juvenile plutons that locally intrude the Yukon‐Tanana terrane represent the northern extension of arc magmatism within Stikinia. Early Jurassic plutons that intrude Stikinia and Yukon‐Tanana terranes were emplaced during crustal thickening (200–195 Ma) and subsequent exhumation (190–178 Ma). The syn‐collisional magmatism migrated to the south and shows increasing crustal contributions with time. This style of magmatism in Yukon contrasts with coeval, juvenile arc magmatism in British Columbia (Hazelton Group), that records southward arc migration in the Early Jurassic. Exhumation and subsidence of the WT in the north were probably linked to the retreating Hazelton arc by a sinistral transform. East of WT, Early Jurassic plutons intruded into Yukon‐Tanana record continued arc magmatism in Quesnellia. Middle Jurassic plutons were intruded after final enclosure of the Cache Creek terrane and imbrication of the Intermontane terranes. The post‐collisional plutons have juvenile isotopic compositions that, together with stratigraphic evidence of surface uplift, are interpreted to record asthenospheric upwelling and lithospheric delamination. A revised tectonic model proposes that entrapment of the Cache Creek terrane was the result of Hazelton slab rollback and development of a sinistral transform fault system linked to the collision zone to the north.
The conserved Pelado/ZSWIM8 protein regulates actin dynamics by promoting linear actin filament polymerization

Pldo/ZSWIM8 is a conserved protein that promotes linear actin polymerization at the expense of branched actin in several contexts, ranging from Drosophila morphogenesis to human cell migration. Actin filament polymerization can be branched or linear, which depends on the associated regulatory proteins. Competition for actin monomers occurs between proteins that induce branched or linear actin polymerization. Cell specialization requires the regulation of actin filaments to allow the formation of cell type–specific structures, like cuticular hairs in Drosophila, formed by linear actin filaments. Here, we report the functional analysis of CG34401/pelado, a gene encoding a SWIM domain–containing protein, conserved throughout the animal kingdom, called ZSWIM8 in mammals. Mutant pelado epithelial cells display actin hair elongation defects. This phenotype is reversed by increasing actin monomer levels or by either pushing linear actin polymerization or reducing branched actin polymerization. Similarly, in hemocytes, Pelado is essential to induce filopodia, a linear actin-based structure. We further show that this function of Pelado/ZSWIM8 is conserved in human cells, where Pelado inhibits branched actin polymerization in a cell migration context. In summary, our data indicate that the function of Pelado/ZSWIM8 in regulating actin cytoskeletal dynamics is conserved, favoring linear actin polymerization at the expense of branched filaments.
Quantifying the strain response in the rat tibia during simulated resistance training used as a disuse countermeasure

Quantifying the Strain Response in the Rat Tibia During Simulated Resistance Training Used as a Disuse Countermeasure. (December 2007) Jay Melvin Jeffery, B.S., Brigham Young University Co-chairs of Advisory Committee: Dr. Harry A. Hogan Dr. Susan A. Bloomfield Disuse of weight bearing bones has been shown to cause bone loss. This poses a health concern for people exposed to microgravity, such as astronauts. Animal studies are used to study factors related to bone loss and countermeasures to prevent bone loss. This study used a hindlimb unloaded (HU) rat model to simulate microgravity and a muscle stimulation countermeasure to simulate resistive exercise. Uniaxial strain gages were implanted on the antero-medial aspect of the proximal tibia to measure the mechanical strain during a typical exercise session. In a separate but parallel study, the exercise was shown to be an effective countermeasure to disuse related bone loss. The current study sought to understand the loading of the bone during the exercise. To determine if the strain response changes during a protocol using this countermeasure, strains were measured on a group of weight bearing animals and a group that were hind limb unloaded and received the countermeasure for 21 days. Strain magnitudes and rates were considered and related to torques at the ankle joint. No significant differences in strain magnitudes were noted between the baseline control group and the hindlimb unloaded group that received the countermeasure. The two kinds of contractions used in an exercise session are isometric and eccentric. The isometric contractions are used to adjust the stimulation equipment for the eccentric contractions, which constitute the exercise. Peak strain levels during the isometric contractions ranged from 900 to 2200 microstrain while the eccentric were 38% lower and ranged from 600 to 1400. Eccentric strain rates were 62% lower than the isometric contractions strain rates. These results indicate that the strain environment
Geometrical analysis on cap-shaped coils for power optimization of the vibration-based electromagnetic harvesting system

This paper presents the new form of coils for electromagnetic energy harvesting system based on topology optimization method which look-liked a cap to maximize the power output. It could increase the number of magnetic flux linkage interception of a cylindrical permanent magnet which in this case is of 10mm diameter. Several coils with different geometrical properties have been build and tested on a vibration generator with frequency of 100Hz. The results showed that the coil with lowest number of winding transduced highest power output of 680μW while the highest number of windings generated highest voltage output of 0.16V.
The Potential Protective Roles of S.cousts (Saussurea costus) Root in Thyroiditis Induced by Amiodarone-Hydrochloride in Experimental Rats

Aim: S.costus root is one of the most medicinal plants that are high in antioxidants. The aim of this work was to investigate the roles of an aqueous extract of S.costus root a portative effect for thyroiditis in rats.Material and Methods: Thirty six rats were randomly divided into six groups (n = 6). The group1 (G1) received only distill water for ten days; group 2 was treated alone with amiodarone hydrochloride 40 mg/kg b.wt. per day for ten days. Groups 3 & 4 were treated orally with an aqueous extract of S. costus alone in two doses (L1 & L2) (50 & 100 mg/kg body weight/day). Groups 5 and 6 were given an aqueous extract of S. costus at two doses (L1 & L2), respectively plus administrated the amiodarone hydrochloride 40 mg/kg body weight and continued for ten days. Results: The results showed the levels of SOD and total anti-oxidant were decreased significantly (p ≤ 0.01) in (G2) rats with thyroiditis compared to all treated groups and the control group. Animals in groups (3-6) ingested extracts S. costus improved and decreased significantly (p ≤ 0.01) in CRP, TNF-a, T3, and T4 hormone levels compared to rats had amiodarone alone. Conclusion: We can conclude that using the S.costus extract considers the potential effect against amiodarone and the side effects. Also, the aqueous extract of S.costus may offer benefits as a treatment to decrease thyroiditis and hyperthyroidism.
Brand's Image, Love, and Loyalty: Is it Enough for Word of Mouth Marketing?

Laptop products are no longer luxury products, and they are commodities commonly used by university students. However yet, every laptop brand has its brand image in the market. Also, Brand love and loyalty have become central concepts in brand and customer relationships. This paper investigates the effects of ‘brand image on brand love’ and ‘brand love on customer loyalty’ and ‘word-of-mouth (WOM) marketing’. Additionally, it investigates which phases of loyalty have priority in creating WOM. Questionnaires had distributed to 300 college students to collect data. Structural equation modeling (SEM) had used to analyze the hypothesis, and from Multi Criteria Decision Making methods, TOPSIS was used to rank the priority of the phases of loyalty. Analyses show that brand love and image remarkably effect on brand loyalty. In addition, it has been determined that brand love affects WOM. The TOPSİS results also reveal that affective loyalty has priority effective on WOM. Other predictors are cognitive, behavioral, and cognitive loyalty, respectively. The results can help practitioners engage customers while creating a brand image and marketing their laptop brands to construct loyal customer support. The ranking of the type of loyalty can also ensure a phase for marketers to develop future strategies.
The Mediating Effect of Symptoms of Anxiety on the Relationship between Appraisal and Teaching Competence

This study determined the mediating effect of symptoms of anxiety on the relationship between appraisal and teaching competence of teachers in San Isidro North and South Districts. The descriptive-correlational research design was utilized and employed stratified random sampling with 300 teachers as sample. Data collection was made through survey instruments. Data analysis was done through Mean, Pearson-r, Multiple Regression and Medgraph using Sobel z-test. Results revealed that symptoms of anxiety was high while appraisal and teaching competence were very high. A positive correlation between appraisal and teaching competence, appraisal and symptoms of anxiety, and symptoms of anxiety and teaching competence was proven in the study. The findings affirmed that symptoms of anxiety played a partial mediation thus, it cannot fully account on the influence of appraisal towards teaching competence. Moreover, a high level of symptoms of anxiety did not hinder teachers’ capability to be very highly competent in teaching.
Promoting Dialogic Action through the Expansion of English Language Learners’ Communicative Repertoires

This action research study sought to foster dialogic action through the expansion of English language learners’ communicative repertoires in a 6th-grade class at a public school in a Colombian town. During the first action research cycle, the restricted concept of communication of the grammar-based syllabus and the competitive and violent interactions between the learners were identified as key issues to address. From a critical perspective of pedagogy and literacy, this study understands that communication in language education should transcend the use of a standard target language, and include multiple linguistic codes and multimodal representative forms. Considering these principles and the issues identified, we designed an action plan for the second action research cycle. This plan consisted of activities that sought to expand English language learners’ communicative repertoires and promote reflections on violence and conflict resolution through the analysis and creation of different visual representations. Data were collected through journal entries, semi-structured interviews, and students’ artifacts. Findings show how the learners have a diverse and differentiated access to communicative repertoires and how they manipulated available representations to transform meanings. As a conclusion, not enough evidence of the emergence of dialogic action was found since competitiveness and violent interactions in the classroom did not significantly change during the intervention. Nonetheless, embracing the learners’ communicative practices created spaces for reflection on complex social and moral topics in the classroom, even if their English linguistic resources were still limited.
Examining the impact of protective clothing on range of movement

This chapter will address another of the possible contributors to the increased metabolic rate observed when wearing protective clothing. The nature of the protection required in industries where workers are exposed to extreme cold, heat and fire often means garments are constructed of thick, heavy, insulative material. The impact of these garments on ease of movement, range of motion and work efficiency has been referred to in the literature using various terms; clothing bulk, movement restriction and hobbling effect. But the effects have been hard to measure and quantify and so the possible involvement of clothing bulk in increasing energy cost in the wearer is still not clear.
EFFECT OF DIFFERENT PLANT EXTRACTS AND ESSENTIAL OILS ON SOME IMPORTANT FUNGAL PATHOGENS CAUSING DAMPING-OFF AND ROOT ROT DISEASES IN SUGAR BEET.

In this study; we screened seven essential oils and 8 different plant extracts for fungitoxic effect against three soil borne pathogens infect sugar beet. The seven essential oils were from commercial products derived from Camphor, thyme, anise, lettuce; groundnut, rocket and caraway oil and used in 3 concentrations (0.5, 1 and 2% w/w). The eight extracts of higher plant species are belonging to seven different plant families including; Pimpinelle anism, Glycerrhiza glabbra L. ; Nigella sativa; Eruca sativa; Eugenia caryophyllus, Artemisia Judaica, Allium cepa and Allium sativum were used to prepare their crude extracts that used in 3 concentrations. (25, 50 and 75% w/v). In laboratory; among essential oils, Thyme, Anise and Comphor oils were the most effective, toxic and inhibit mycelial growth of on fugal species. On the contrast, the other essential oils of lettuce, ground nut, rockets and caraway did not cause any toxic effect against all pathogenic fungi under study compared with controls. Among 8 plant extract tested garlic and onion extracts were the most effective and toxic for all fungi tested. The persistence of antifungal activity was different among extracts. All showed decreasing zone of inhibition with time, except Cloves, Artemisia, Onion and Garlic which retained its full activity against the three fungi for the whole incubation period especially at 50 and 75% concentrations. However, the suppressive effect of other extracts against the other pathogens was either not affected or slightly decreased with time. The highly toxic and promising plant extracts and essential oils of garlic, onion, Artemisia, anise oil, thyme oil were tested in greenhouse and field experiments. In greenhouse and Field experiment, data showed that plant extracts, thyme oil and anise oil were effective in controlling pre-post emergence damping-off and significantly decreased root rot incidence and severity compared with the controls and fungicide. Yield component of total soluble sugars (T.s.s.), sucrose percent in root and sugar purity were increased. All seed treatments with selected plant extracts and oils, significantly increased these yield parameters. Anise oil showed the most significant effect and increase of T,S.S and sucrose percent in roots of sugar plants assayed from plants grown from seed in plots treated with Anise oil in both 2006 and 2007 growing seasons compared with controls and fungicide treatments. Thyme oil and onion extract showed moderate but improved increase in these yield components.
Tissue specific dual RNA-seq defines host-parasite interplay in murine visceral leishmaniasis caused by Leishmania donovani and Leishmania infantum

Visceral leishmaniasis is associated with hepato-splenomegaly and altered immune and haematological parameters in both pre-clinical animal models and humans. We studied mouse experimental visceral leishmaniasis caused by Leishmania infantum and Leishmania donovani in BALB/c mice using dual RNA-seq to investigate the transcriptional response of host and parasite in liver and spleen. We identified only 4 species-specific parasite expressed genes (SSPEGs; log2FC >1, FDR <0.05) in the infected spleen, and none in the infected liver. For the host transcriptome, we found 789 differentially expressed genes (DEGs; log2FC >1, FDR <0.05) in the spleen that were common to both infections, with IFNγ signaling and complement and coagulation cascade pathways highly enriched, and an additional 286 and 186 DEGs that were selective to L. donovani and L. infantum infection respectively. Among those, there were network interactions between genes of amino acid metabolism and PPAR signaling in L. donovani infection and increased IL1β and positive regulation of fatty acid transport in L. infantum infection, although no pathway enrichment was observed. In the liver, there were 1939 DEGs in mice infected with either L. infantum or L. donovani in comparison to uninfected mice, and the most enriched pathways were IFNγ signaling, neutrophil mediated immunity, complement and coagulation, cytokine-chemokine responses and hemostasis. Additionally, 221 DEGs were selective in L. donovani and 429 DEGs in L. infantum infections. These data show that the host response for these two visceral leishmaniasis infection models is broadly similar, and ∼10% of host DEGs vary in infections with either parasite species. Importance Visceral leishmaniasis (VL) is caused by two species of Leishmania parasites, L. donovani in the Old World and L. infantum in the New World and countries bordering the Mediterranean. Although cardinal features such as hepato-splenomegaly and alterations in blood and immune function are evident, clinical presentation may vary by geography, with for example severe bleeding often associated with VL in Brazil. Although animal models of both L. donovani and L. infantum have been widely used to study disease pathogenesis, a direct side-by-side comparison of how these parasites species impact the infected host and/or how they might respond to the stresses of mammalian infection has not been previously reported. Identifying common and distinct pathways to pathogenesis will be important to ensure that new therapeutic or prophylactic approaches will be applicable across all forms of VL.
The Effect of Sialic Acid on MiR-320a and Let-7e Expression in Human Glial Cell Line

Introduction: Sialic acid is pivotal in various critical physiological events at molecular and cellular levels and pathological processes. Changes in sialic acid concentration are observed in many pathological processes; for example, some available data exist on the evaluated level of sialic acid and neurodegenerative prevalence. Presumably, sialic acid can play a significant role in regulating a diverse range of uncovered neurodegeneration factors and downstream targets. matrix metalloproteinases 9 (MMP9) is one factor that changes the exposure of different concentrations of sialic acid solution. Hence, we aimed to examine the possible effect of sialic acid solution exposure on the glial cell line in the expression patterns of miR-320a and let-7e as two upstream factors. Methods: Human glial cell line was prepared from the Pasteur Institute of Iran and cultured in a dulbecco’s modified eagle medium (DMEM) with 10% fetal bovine serum (FBS). The IC50 value of sialic acid was obtained by colorimetric assay for assessing cell metabolic activity 3-(4,5-Dimethylthiazol-2-yl (MTT), and the glial cell line was treated with sialic acid in 300, 500, 1000 μg/mL for 24 h to investigate the effect of the sialic acid ligand on the expression pattern of the miR-320a and let-7e. Total RNA was isolated from approximately 10×106 glial cells and was used from each sample for complementary dna (cDNA) synthesis. For quantitative analysis of miR-320a and let-7e, we used real-time polymerase chain reaction (PCR), and for statistical analysis, the SPSS v. 21 software was applied. Results: Analyzing the real-time data revealed that the expression of miR-320a and let-7e was significantly increased (P<0.0001) in 300, 500, and 1000 μg/mL treated glial cells by sialic acid compared to the control group. Conclusion: A possible linkage of sialic acid on miR-320a and let-7e regulation was observed in the glial cell line as proinflammatory factors in the inflammation pathway. Highlights Differing in sialic acid concentration is seen in various pathological states. MicroRNAs play a role in numerous biological processes and human disorders. miR-320a and let-7e expression levels displayed a significant increase in different sialic acid concentrations. Plain Language Summary Inflammation in the nervous system occurs because of numerous factors. Sialic acid is an inflammatory factor that promotes cellular inflammation, particularly in the glial cells. That is why it could serve as a useful model for simulating several neurodegenerative diseases, including Parkinson's and Multiple sclerosis. Changes in sialic acid concentration are observed in many pathological states, which could be a useful marker for identifying the inflammatory process. The present study was carried out to examine the impact of different concentrations of sialic acid on two non-coding RNAs in glial cells. Our research shows that these two microRNAs greatly increased when responding to sialic acid. We suggest that these two microRNAs are contributed to the neuroinflammatory pathways related to sialic acid.