Miracle-dz/UniFAR-FTUs huggingface dataset:
Studies on the Efficacy of Various Antimycotic Drugs on Emerging and Reemerging, Superficial, Cutaneous and Subcutaneous Mycotic Infections

Introduction: The efficacy of five systemic and topical antifungal medications, Voriconazole, clotrimazol, beclometasone, Itraconazole, and Fluconazole, on dermatomycosis, which affects the superficial layers of the skin, nails, foot, and hair, was tested with 180 patients. Methods: Included were specimen collection, processing, microscopy, and culture, as well as antifungal susceptibility testing using the E-test method. The Candida species were confirmed and their susceptibility to Voriconazole and Fluconazole was tested using the automated Vitek 2. Results: The final strain identification indicated 41 dermatophytes (69.49%), 11 non-dermatophytic molds (NDM) (18.64%), and 7 yeasts (11.87%). (candida). Candida was the most prevalent nondermatophyte species found. Trichophyton rubrum was the most prevalent species isolated in Tinea corporis, T. cruris, T. capitis, and T. faciei. When tested with the E strips, all dermatophyte strains showed the greatest vulnerability to beclometasone and clotrimazole (MIC range of 0.04–0.64), but homogeneous resistance to Fluconazole (i.e. MIC 32 g/ml). Conclusion: Variation in species distribution was shown to be statistically significant (p = 0.001) in terms of clinical presentation.
Medical interns’ views on the strategies for reducing antibiotic misuse in the hospitals—what guidelines do they follow?

Objectives Although the topic of antibiotic misuse is taught in medical schools, interns (fresh medical graduates) still encounter barriers to appropriate antibiotic prescription when they practice in hospitals under supervision. The impact of teaching in medical school, antibiotics stewardship program (ASP), and prescription guidelines was uncertain. This study explored the medical interns’ views on antibiotic use and resistance, and their perceived enablers to appropriate antibiotic prescription. Methods Two focus groups were conducted among medical interns with rotation experiences in different public hospitals of Hong Kong. The identified themes about attitudes to antibiotic resistance and enablers to appropriate antibiotic prescription were further examined by a questionnaire survey with 77 respondents. Results The interns had lower preferences for tackling antibiotic resistance as they feared of delayed prescriptions. Guidelines provided by international evidence-based clinical resources and the interns’ working hospitals were stronger enablers to appropriate antibiotic use than education materials from schools and the government. Qualitative findings revealed that the interns were aware of the existing ASP but doubted its effectiveness as it failed to get the prescribers’ attention. They followed guidelines in their wards but perceived guidelines from local health authorities user-unfriendly. Knowledge from medical school was not very applicable. Varying prescribing practices between hospitals and the densely placed hospital beds made it difficult to prevent the spread of antimicrobial resistance. Conclusions Minimizing delayed prescription is of a higher priority than tackling antibiotic resistance in medical interns’ perspective. Interventions should target guidelines in hospitals and simplify the interface of local guidelines.
Cardiac CT for intra-cardiac thrombus detection in embolic stroke of undetermined source (ESUS)

Introduction: Embolic stroke of undetermined source (ESUS) is a common medical challenge regarding secondary prevention strategy. Cardiac imaging is the cornerstone of embolic stroke workup, in an effort to diagnose high risk cardio-embolic sources. Cardiac computed tomography angiography (CCTA) is an emerging imaging modality with high diagnostic performance for intra-cardiac thrombus detection. The yield of CCTA implementation in addition to standard care in ESUS workup is unknown. Thus, the aim of this study was to assess the utility of CCTA in detecting intra-cardiac thrombi in the routine ESUS workup. Patients and methods: This is a retrospective observational analysis of ESUS cases managed in vascular neurology unit between 2019 and 2021. Within this ESUS registry, consecutive patients undergoing CCTA were included and carefully analyzed. Results: During the study period 1066 Ischemic stroke (IS) cases were treated and evaluated. 266/1066 (25%) met ESUS criteria and 129/266 (48%) underwent CCTA. Intra-cardiac thrombus was detected by CCTA in 22/129 (17%; 95% CI, 11.5%−23.5%) patients: left ventricular thrombus (LVT) in 13 (10.1%) patients, left atrial appendage (LAA) thrombus in 8 (6.2%) patients, and left atrial (LA) thrombus in 1 (0.8%) patient. Only 5/22 (23%) of these thrombi were suspected, but could not be confirmed, in trans-thoracic echocardiogram (TTE). Among CCTA-undergoing patients, 27/129 (21%; 95% CI, 14%−28%) were found to have an indication (including pulmonary embolism) for commencing anticoagulation (AC) treatment, rather than anti-platelets. In favor of CCTA implementation, 22/266 (8.2%; 95% CI, 4.9%−11.5%) patients within the entire ESUS cohort were diagnosed with intra-cardiac thrombus, otherwise missed. Conclusion: CCTA improves the detection of intra-cardiac thrombi in addition to standard care in ESUS patients. The implementation of CCTA in routine ESUS workup can change secondary prevention strategy in a considerable proportion of patients. Graphical abstract
The Levels and Sources of Nitrous Acid (HONO) in Winter of Beijing and Sanmenxia

HONO concentrations in Beijing (BJ) and Sanmenxia (SMX) were simultaneously measured in winter with a duration of 1 month, and the sources and sinks of HONO in the two cities were comparably analyzed. BJ and SMX had different pollution characteristics. Direct vehicle emission made a contribution to observed HONO of about 28% in BJ, whereas it contributed to HONO only about 12% in SMX. Additionally, direct emission from coal combustion in SMX also made a significant contribution to atmospheric HONO, which could achieve to be 13%. In BJ, nighttime NO2 conversion on the aerosol and ground surfaces contributed to HONO sources of 15% and 27%, respectively. In SMX, nighttime NO2 conversion on the aerosol and ground surfaces contributed to HONO sources of 40% and 30%, respectively. Daytime NO2 heterogeneous conversion (including photo‐enhanced conversion) on the aerosol and ground surfaces was important in SMX. Daytime NO3− photolysis contributed 9% HONO in SMX and 4% in BJ. The primary OH production rates from photolysis of daytime HONO in both BJ and SMX were three orders of magnitude faster than those from photolysis of O3, revealing the dominant role of HONO in local atmospheric chemistry of the two cities in winter.
Determining the genital hygiene behaviours of visually impaired women

Genital hygiene is one of the most important factors in the protection of women’s reproductive health. Thus, detailed knowledge of the genital hygiene behaviours of visually impaired women is crucial for preventive and curative health services. This descriptive study was conducted to determine the genital hygiene behaviours of visually impaired women. The study was conducted with 90 visually impaired women who were members of the ‘Altı Nokta Körler’ association. A data collection form was developed within the scope of the study. The data were collected through the face-to-face interview method between October 2018 and June 2019. The results show that the ratios of women who think that self-care and genital hygiene behaviours are affected by their visual impairment are 18.9% and 21.1%, respectively. Of those who think that visual impairment affects their self-care, 76.5% need someone else to notice their lack of self-care, and the remaining women notice this lack through their bodily reactions, such as bad odours and dirt. It was found that more than half of the women (58.9%) had a vaginal shower only after sexual intercourse. Among women, 35.6% of them thought that visual impairment was an obstacle to gynaecological examination. The regular gynaecological examination rates of these women were only 8.9%. It was found that the majority of women (78.9%) experienced abnormal vaginal discharge, but only 23.9% applied to a health institution. Visually impaired women have similar deficient genital hygiene behaviours to non-disabled women. In addition, visually impaired women face difficulties in maintaining personal and genital hygiene and in receiving health services.
Resilient Monitoring and Control Systems: Design, Analysis, and Performance Evaluation.

Resilient Monitoring and Control Systems: Design, Analysi s, and Performance Evaluation by Maruthi T Ravichandran Chair: Professor Semyon M. Meerkov Critical infrastructure systems (i.e., power plants, powe r grids, transportation networks, chemical plants, etc.) and their sensor networks are vulner abl to cyber-physical attacks. Cyber attacks refer to the malicious manipulation of the sen sor data, while physical attacks refer to the intentional damage of the plant components, by a n adversary. The goal of this dissertation is to develop monitoring and control systems t hat are resilient to these attacks. The monitoring system is termed resilient if it provides the least uncertain (in terms of the minimum entropy) process variable estimates and plan t condition assessment. Similarly, the feedback control system is termed resilient if i t identifies the actuators under attack and generates the best possible control signals (in t erms of the largest probability of maintaining the process variables in the desired range). The resilient monitoring system (RMS) developed in this res earch consists of five layers: Data quality acquisition, process variable assessmen t, pla t condition assessment, sensor network adaptation, and decentralized knowledge fusio n. The techniques involved in each of these layers are rigorously analyzed and are shown to identify the plant condition normal or anomalous in a reliable and timely manner. The de veloped RMS is applied to a model of a power plant, and its performance is evaluated u nder several cyber-physical x attack scenarios. The measure of resiliency is quantified us ing Kullback-Leibler divergence and is shown to be high in all scenarios considered. The resilient control system (RCS) is developed based on two approaches: Model predictive control (MPC)-based approach and synchronous dete ction (SD)-based approach. In the MPC-based approach, a control input is calculated using the information provided by the RMS. The goal here is to steer the process variable to the d esire value, while ensuring that it always remains within a safe domain. In the SD-based a pproach, the condition of the sensor and actuator is assessed using the method of synch ronous detection. Then, using this assessment, the controller is modified (if possible) so that the effects of the attacks on the closed loop system response are eliminated. Using simul ations, it is shown that both these approaches are viable for the design of RCS. Thus, the main contribution of this research is in providing the theoretical foundation for the design of resilient monitoring and control systems a pplicable to a class of critical infrastructure systems, characterized by complex interac ions of continuous process variables.
Special Issue: Women of Color and Leadership Journal: Advances in Developing Human Resources Expanding Our Voices? A Review of Human Resource Development Literature on Women of Color Leaders Over the Last Decade

Problem In 2009, a collective of African American (Black) women challenged race-neutral and gendered perspectives of leadership in a Special Issue of Advances in Developing Human Resources. Since that date, other women of color have added cultural perspectives that have expanded the need to revisit a problem that has rendered invisibility and silence to this group of leaders. Solution Women of color in positions of leadership have learned through historical and cultural experience how to strategically navigate organizational and institutional barriers by leading authentically. More significantly, they have learned how to balance status and place and to recognize that place defines their leadership reality. Stakeholders Human Resource Development (HRD) scholars and researchers who study leadership. HRD practitioners, organizational leaders, and others who are responsible for leadership development programs that are inclusive. Women of color leaders.
The cheeseboard in Dutch fine dining restaurants, I: Practices and opinions of restaurant professionals

The difficulties in serving a cheeseboard are explored in this paper. From literature 1940–2010, for accompanying cheeses, a shift was found from red to white wines and from dry to sweeter wines. There is also a tendency to more and sweeter garnishes with the cheese. Interviews with professionals from nine Dutch restaurants largely confirmed these tendencies. In most restaurants, a varied cheeseboard was offered with sweet breads and garnishes. Many customers only finished the wine from the main dish with the cheeseboard. When a new wine was ordered, it was most of the time a sweet wine that did not match with all the cheeses of the cheeseboard. Recommendations for improving this situation are given.
Investigation of Mechanical and Tribological Behaviour of Dual Particles Reinforced Al Matrix Composites

In the present scenario, dual particles reinforced aluminum matrix composites have a vast number of applications in aerospace, marine, transportation, structural and non-structural applications like drive shaft, connecting rod, piston and brake drum. The main objective of this work is for evaluating the mechanical and the tribological behavior of aluminium oxide and graphite particulate reinforced with AA6351 composites were prepared by liquid metallurgy route (Stir casting). Hardness and tensile strength of the composite and the base alloy were investigated. The microstructure of manufactured composite and the base alloy were examined by an optical microscope. Optical microscopy analysis confirmed the nearly uniform distribution of Al2O3/Gr twin particles in Al matrix. The tensile strength and hardness of the composites have significantly improved by the presence of Al2O3/Gr.
Comparison of treatment of severe rheumatoid arthritis patients with biological agents and JAK-STAT inhibitors. An observational study

Introduction Treatment of severe rheumatoid arthritis (RA) is currently based either on biological agents or Janus kinase/signal transducer and activator of transcription inhibitors, most often in combination with methotrexate (MTX). Aim of the study The aim of the study was to compare the effectiveness and side effects of bio- logic disease-modifying antirheumatic drugs (bDMARDs) and targeted synthetic (ts) DMARDs treatment. Material and methods The analysis included 108 RA patients with active disease treated with MTX 25 mg per week. Eighty patients (group I) were treated with bDMARDs and 28 patients (group II) with JAK-STAT inhibitors. The duration of morning stiffness, pain on Visual Analogue Scale (VAS), 28-joints Disease Activity Score (DAS28) and Simplified Disease Activity Score (SDAI) were assessed. Classical radiographic images of patients’ hands and feet using the Larsen and Dale’s criteria were evaluated. The effects of treatment with bDMARDs and tsDMARDs were analyzed. Results All studied patients presented at least Larsen and Dale’s stage 3 of X-ray changes typical for RA. There were no statistically significant differences in disease duration, ESR, CRP, DAS28 and SDAI values between studied groups. Patients from group II previously used higher numbers of bDMARDs than group I treated with bDMARDs. Low disease activity after treatment was achieved by all patients; therefore patients from group II (treated with tsDMARDs) achieved lower values of patients’ global assessment on VAS. Conclusions The results of the present observational study indicated that treatment with JAK inhibitors is very promising. These drugs are not inferior in effectiveness to bDMARDs. It is important to monitor patients for thromboembolic events before and during JAK treatment.
Book Review: Who Cares? Attracting and Retaining Care Workers for the Elderly

This study was prepared and published at the onset of the COVID-19 pandemic and its themes have become all too familiar over the past 18 months. Elderly care and its workforce have been disproportionately impacted by the pandemic. Workers in the sector have faced terrible circumstances and many elderly people and their carers have lost their lives prematurely. The pandemic has confirmed the fragility and structural problems in the provision of long-term care around the world and exacerbated the recruitment and retention challenges that are the focus of this study. At the same time, the pandemic has focused more public attention on those who provide care, bringing a previously invisible low status workforce into the limelight. This has generated an EU commitment to a new European Care Strategy and prompted many reports looking at the employment and working conditions in long-term care. Nevertheless, the challenges facing the sector remain acute (European Commission, 2021; Kessler et al., 2020). The study looks at the evidence base and considers best practices for stemming the crisis in long-term care. It draws on survey responses and interviews with country delegates, supplemented by national data, EU Labour Force Survey data and additional literature. It considers the situation of long-term carers for the elderly who provide their services to recipients at home or in institutions. These carers comprise two main occupations, nurses and personal care workers. In OECD countries over 70 per cent of long-term care workers are personal carers. In a context of rising demand for care and the shift of care from hospital to community settings, care demand is outstripping the supply of long-term care workers, and workforce shortages will worsen without urgent action. In the aggregate, OECD countries need to more than double the current number of longterm care workers to maintain existing ratios of caregivers to the elderly. These structural challenges stem from insufficient recruitment and retention, connected to low status, poor pay and working conditions, inadequate training and limited attention to skill acquisition and deployment. Staff shortages have a severe impact on quality of care, including unmet care needs and unnecessary hospital admissions. The study details the main characteristics of the workforce, which comprises predominantly middle-aged women, with a high share of foreign-born workers. Foreign-born workers make a vital contribution and represent over 20 per cent of the OECD countries’ long-term care workforce. They are overrepresented in the care sector and are susceptible to exploitation, for many reasons. These include their employment and immigration status, for example, as undeclared workers hired privately by households and because compliance with employment regulations, such as minimum wage provisions, is uneven. Part-time working, often on an involuntary basis, is also significant. 109998010999801099980 TRS0010.1177/10242589221099980TransferBook Reviews book-review2022
Should Endometrial Cancer Treatment Be Centralized?

Simple Summary Endometrial cancer (EC) is the most frequent cancer of the female genital tract in Western and emerging countries. It is commonly thought to be easy to treat as it is usually diagnosed at an early stage, and hysterectomy with bilateral adnexectomy alone is the only treatment required. The progressive replacement of systematic lymphadenectomy with sentinel lymph node biopsy has also fostered this erroneous belief. In fact, if mistreated, EC has a high lethality due to its poor response to chemotherapy in the cases of advanced stage and recurrence. In this paper we reviewed the literature to understand whether the treatment of EC should be reserved for gynecologic oncologists and whether treatment of EC patients should be centralized in high-volume hospitals. We also evaluated the contribution of other specialists involved in the diagnostic and therapeutic pathways of EC. Finally, we suggest a possible network to treat EC patients to ensure effective staging and treatment. Abstract Endometrial cancer (EC) is the most common malignancy of the female genital tract in Western and emerging countries. In 2012, new cancer cases numbered 319,605, and 76,160 cancer deaths were diagnosed worldwide. ECs are usually diagnosed after menopause; 70% of ECs are diagnosed at an early stage with a favorable prognosis and a 5-year overall survival rate of 77%. On the contrary, women with advanced or recurrent disease have extremely poor outcomes because they show a low response rate to conventional chemotherapy. EC is generally considered easy to treat, although it presents a 5-year mortality of 25%. Though the guidelines (GLs) recommend treatment in specialized centers by physicians specializing in gynecologic oncology, most women are managed by general gynecologists, resulting in differences and discrepancies in clinical management. In this paper we reviewed the literature with the aim of highlighting where the treatment of EC patients requires gynecologic oncologists, as suggested by the GLs. Moreover, we sought to identify the causes of the lack of GL adherence, suggesting useful changes to ensure adequate treatment for all EC patients.
The Reciprocal Rebellion: Promoting Discussion in Authoritarian Schools

ABSTRACT In her ethnographic study, Factories for learning: Making race, class and inequality in the neoliberal academy (2017), Christine Kulz depicts an oppressive system in a United Kingdom secondary school, Dreamfields. Kulz illustrates how many children and teachers are stripped of their autonomy, rights and dignity. In this article, Northfields, a school like Dreamfields, is profiled. Like Dreamfields, Northfields is an authoritarian, heavily surveilled institution with both teachers and pupils often being reprimanded for minor transgressions. This case study shows how an English teacher managed to successfully use Reciprocal Teaching in her classroom, even though its emphasis on co-operative learning was contrary to the spirit of Northfields. Reciprocal Teaching changes the way pupils and teachers see themselves, improves their discussion, reading and exam results. Reciprocal Teaching re-orders education by fostering meaningful relationships, challenging the hegemony of neoliberal schools: it is a rebellion against their authoritarianism.
Properties of doubly heavy baryons in QCD

: The study of the properties of doubly heavy baryons represents a promising area in particle physics. It can provide us with information about Cabibbo–Kobayashi–Maskawa (CKM) matrix elements and the low energy dynamics of QCD. They have a very rich phenomenology. The investigation of weak, electromagnetic, and strong decays has a vital importance for understanding the dynamics of doubly heavy baryons. The main ingredients of such studies are the spectroscopic parameters, the strong coupling constants, and the transition form factors. For calculations of these quantities, non-perturbative methods are needed. One of these methods is the QCD sum rules. In the present work, we review our studies on the properties of the doubly heavy baryons within the sum rules method, focusing mainly on the mass and strong coupling constants of the doubly heavy baryons. In addition, the radiative decays of doubly heavy baryons are estimated using the vector dominance model. We also make few remarks on the semileptonic decays of the doubly heavy baryons.