Miracle-dz/UniFAR-FTUs huggingface dataset:
Benefit from retrieval practice is linked to temporal and frontal activity in healthy young and older humans

Abstract Retrieval practice improves retention of information in long-term memory more than restudy, but the underlying neural mechanisms of this “retrieval practice effect” (RPE) remain poorly understood. Therefore, we investigated the behavioral and neural differences between previously retrieved versus restudied items at final retrieval. Thirty younger (20–30 years old) and twenty-five older (50+ years old) adults learned familiar and new picture stimuli either through retrieval or restudy. At final recognition, hemodynamic activity was measured using functional magnetic resonance imaging (fMRI). Behaviorally, younger and older adults showed similar benefits of retrieval practice, with higher recollection, but unchanged familiarity rates. In a univariate analysis of the fMRI data, activation in medial prefrontal cortex and left temporal regions correlated with an individual’s amount of behavioral benefit from retrieval practice, irrespective of age. Compatible with this observation, in a multivariate representational similarity analysis (RSA), retrieval practice led to an increase in pattern similarity for retested items in a priori defined regions of interest, including the medial temporal lobe, as well as prefrontal and parietal cortex. Our findings demonstrate that retrieval practice leads to enhanced long-term memories in younger and older adults alike, and this effect may be driven by fast consolidation processes.
Risk perception and travel satisfaction associated with the use of public transport in the time of COVID-19. The case of Turin, Italy

The present study examined the association between risk perception and travel satisfaction related to the use of public transport (PT) during COVID-19 pandemic in Turin, Italy. A total of 448 PT users took part in an online survey conducted from January to March 2021. It investigated safety and risk perception related to the use of PT, and the users’ subjective experience, measured through the Satisfaction with Travel Scale (STS). These perceptions were compared for three time scenarios: before the pandemic, during the pandemic, and in the future at the end of the pandemic emergency. Results showed that COVID-19 influenced respondents risk perception both during the pandemic and in their projections about the future, especially for females. The risk of contagion from COVID-19 is perceived as higher inside a PT vehicle than in the adjacent/waiting spaces. Regarding travel satisfaction, the overall scores of the STS indicated that the pandemic has impacted reported well-being while travelling, both now and in the future. The dimension of activation shifted towards the negative pole and did not indicate a return to risk perception before the pandemic levels at the end of the crisis (especially for females). Respondents reported a significant decrease in their level of pleasure and satisfaction during the pandemic, but expect that in the future these levels will go back to the levels previously experienced. Regarding travel satisfaction, PT users aged 36 to 50 years reported the highest level of satisfaction, while younger users (18 to 35 years) reported the lowest degree of satisfaction in all three time scenarios. Overall, the results clearly pinpoint that health-related perceived risk is becoming a key determinant for PT use. Within this context, different dimensions of travel satisfaction proved to be impacted differently by the pandemic, for both current and future scenarios.
Multilevel Safety Intervention Implementation Strategies for Nigeria Construction Industry

This study was aimed at examining the relationships between the effectiveness of safety intervention programmes and implementation strategies in the Nigeria construction industry. Structured questionnaires were distributed to construction stakeholders across some selected states in Nigeria and the data generated were analysed using Pearson’s product moment correlation. The study found that the effectiveness of safety intervention programmes for construction site accidents prevention is significantly related to the communication implementation strategies. Based on the principles of social ecological theory and UNICEF’s communication for development strategies, this study developed a multilevel safety intervention implementation strategy for construction industries in Nigeria. Four communication strategies, namely, advocacy, social mobilisation, social change communication, and behaviour change communication, which are central to the effectiveness of safety intervention implementation programmes for construction site accidents prevention, were identified. It further revealed that these communication strategies could be individually and collectively applied at different intervention levels but that the greatest effect would be felt when all strategies are systematically combined with more efficient use of resources. The study recommended systematic actions by policy makers, construction organisations, and various community groups towards construction safety interventions, since maximum effect could only be felt when safety interventions are implemented across all levels.
Correlates of prevalent syphilis infection among men who have sex with men (MSM) living with HIV attending the HIV clinic in Trinidad

Background Syphilis among men who have sex with men (MSM) living with HIV is of public health concern, thus the objective of the study is to determine the correlates of prevalent syphilis infection in this population so that urgent interventions could be instituted. Methods A cross-sectional study was conducted during the period September 2020-June 2021 among MSM who attended a large HIV Clinic in Trinidad. A questionnaire was administered to obtain socio-demographic data and correlates of prevalent syphilis and patients were screened for syphilis using the traditional algorithm. Descriptive and bivariate analyses were conducted and multivariable logistic regression factors was used to assess factors significantly associated with a syphilis diagnosis. Results Two hundred and sixty four MSM were enrolled; age range 18–64 years, median age 33 years and 89 (34.4%) were actively bisexual. The prevalence of syphilis was 28% (74/264) and 89.2% (66/74) of these infections were asymptomatic. Multivariable logistic regression analysis showed that those patients who participated in sex with anonymous partners (OR 2.09; 95% CI, 1.03–4.26), those with a previous diagnosis of syphilis (OR 5.16; 95% CI, 1.03–25.83) and those who used marijuana in the last 12 months (OR 2.13; 95% CI, 1.14–3.96) were more likely to be diagnosed with syphilis. Conclusion There is a high prevalence of asymptomatic syphilis among MSM living with HIV in Trinidad. Repeat episodes of syphilis and anonymous sex may play a role in the transmission dynamics of T pallidum infection in this population, thus urgent public health prevention interventions are warranted.
Energy Efficiency of a Biofuel Production System

Manufacturing engineering is supposed to provide analyses related to various aspects of man- ufacturing and production in order to maximise technological, energy, and economic gains in relevant production processes. The present paper gives a recapitulation of several pub- lications by present authors, presenting considerations of the energy eﬃciency of biofuel production. The energy eﬃciency is understood as the ratio of energy obtained from biofu- els produced basing on crops from a particular area to the energy required to satisfy needs of all subsidiary processes assuring correct functioning of the production system, starting from operations aimed to obtain agricultural crops, and ending with the conversion of the crops onto biofuels. Derived by the present authors, the mathematical model of energy eﬃciency of biofuel production is extended to a more general form, and applied to the analysis of quantitative relations between energy eﬃciency of sc. “energy plantations”, and further elements of biofuel production system converting harvested biomass into biofuel. Investigations are aimed towards the determination of the role of biomass as a source of energy.
Clinical utility of comprehensive genomic profiling in Japan: Result of PROFILE-F study

Introduction Clinical sequencing has provided molecular and therapeutic insights into the field of clinical oncology. However, despite its significance, its clinical utility in Japanese patients remains unknown. Here, we examined the clinical utility of tissue-based clinical sequencing with FoundationOne® CDx and FoundationOne® Heme. Between August 2018 and August 2019, 130 Japanese pretreated patients with advanced solid tumors were tested with FoundationOne® CDx or FoundationOne® Heme. Results The median age of 130 patients was 60.5 years (range: 3 to 84 years), and among them, 64 were males and 66 were females. Major cancer types were gastrointestinal cancer (23 cases) and hepatic, biliary, and pancreatic cancer (21 cases). A molecular tumor board had been completed on all 130 cases by October 31, 2019. The median number of gene alterations detected by Foundation testing, excluding variants of unknown significance (VUS) was 4 (ranged 0 to 21) per case. Of the 130 cases, one or more alterations were found in 123 cases (94.6%), and in 114 cases (87.7%), actionable alterations with candidates for therapeutic agents were found. In 29 (22.3%) of them, treatment corresponding to the gene alteration was performed. Regarding secondary findings, 13 cases (10%) had an alteration suspected of a hereditary tumor. Of the 13 cases, only one case received a definite diagnosis of hereditary tumor. Conclusions Our study showed that clinical sequencing might be useful for detecting gene alterations in various cancer types and exploring treatment options. However, many issues still need to be improved.
Wandering of the modal parameters in existing building: application to structural health monitoring

Ambient vibrations in building is of increasing interest for applications in mechanical engineering, civil engineering and earthquake engineering. With advances in data acquisition systems (number of measurement points, continuous recording, low-noise instrument) and advances in signal processing algorithms, further and better studies can be conducted on civil engineering structures for evaluating their modal parameters and their physical properties. This study is focused on long- and short-term variations of frequency and damping in buildings. After a brief overview of the physical meanings and the practical interest for earthquake engineering, some examples are shown. They concerns the transient variations of modal parameters related with non-linear behaviour of the system, the permanent decrease of frequency and damping after extrem event and the natural wandering of modal parameters, often related to atmospheric conditions. These changes, however, confirms the great stability and confidence measurements in buildings using modal analysis. This information helps to consider the relevancy of analysis of existing monitoring (damage, ageing, and so on) and can better calibrate the mechanical models used for the analysis of seismic vulnerability of existing structures, and thereby help reduce variability of their estimates.
Mechanical Ventilation in COVID-19 Patients: Insights into the Role of Age and Frailty from a Multicentre Observational Study

In patients with COVID-19, frailty has been shown to better predict outcomes than age alone. We investigated factors associated with mechanical ventilation (MV) during hospitalization for COVID-19 among older adults in a multicentre study during the first two waves in Italy. Using data from the FRACOVID project, we included consecutive patients admitted to the participating centres during the first and second waves. We recorded sociodemographics, comorbidities, time since symptom onset, ventilatory support at admission, and chest X-ray findings. Frailty was assessed using a frailty index (FI). Results are reported as hazard ratios (HR) with 95%CI. 1,344 patients were included; 487 females (36.2%), median age 68 (56; 79) years; 52.4% had hypertension, 10.6% had chronic obstructive pulmonary disease, 15.2% were obese. Median FI was 0.088 (0.03, 0.20), and 67% had bilateral consolidations at admission. Median time since symptom onset was 7 days (4, 10). During hospitalization, 47 patients (3.6%, 95%CI 0.33-13.6%) received MV. Multivariable Cox regression analysis found that the likelihood of intubation decreased with increasing age (HR 0.945 (95%CI 0.921-0.969), p<0.0001), while heart rate >110bpm (HR 3.429 (95%CI 1.583-7.429), p=0.0018), and need for continuous positive airway pressure (CPAP) at admission (HR 2.626 (95%CI 1.330-5.186), p=0.0054) were significantly associated with a greater likelihood of intubation. Older patients are less likely to receive intubation, while those with heart rate >110 bpm and need for CPAP at admission are more likely to receive MV during hospitalization for COVID-19.
Autophagy and Diabetic Encephalopathy: Mechanistic Insights and Potential Therapeutic Implications

Diabetic Encephalopathy (DE) is one of the complications of diabetes mellitus (DM) in the central nervous system. Up to now, the mechanisms of DE are not fully discussed by the field. Autophagy is an intracellular degradation pathway crucial to maintain cellular homeostasis by clearing damaged organelles, pathogens, and unwanted protein aggregates. Increasing evidence has demonstrated that autophagy might play an essential role in DE progress. In this review, we summarize the current evidence on autophagy dysfunction under the condition of DE, and provide novel insights of possibly biological mechanisms linking autophagy impairment to DE, as well as discuss autophagy-targeted therapies as potential treatments for DE
Prediction of the potential geographical distribution of Betula platyphylla Suk. in China under climate change scenarios

Climate is a dominant factor affecting the potential geographical distribution of species. Understanding the impact of climate change on the potential geographic distribution of species, which is of great significance to the exploitation, utilization, and protection of resources, as well as ecologically sustainable development. Betula platyphylla Suk. is one of the most widely distributed temperate deciduous tree species in East Asia and has important economic and ecological value. Based on 231 species distribution data points of Betula platyphylla Suk. in China and 37 bioclimatic, soil, and topography variables (with correlation coefficients < 0.75), the potential geographical distribution pattern of Betula platyphylla Suk. under Representative Concentration Pathway (RCP) climate change scenarios at present and in the 2050s and 2070s was predicted using the MaxEnt model. We analyzed the main environmental variables affecting the distribution and change of suitable areas and compared the scope and change of suitable areas under different climate scenarios. This study found: (1) At present, the main suitable area for Betula platyphylla Suk. extends from northeastern to southwestern China, with the periphery area showing fragmented distribution. (2) Annual precipitation, precipitation of the warmest quarter, mean temperature of the warmest quarter, annual mean temperature, and precipitation of the driest month are the dominant environmental variables that affect the potential geographical distribution of Betula platyphylla Suk. (3) The suitable area for Betula platyphylla Suk. is expected to expand under global warming scenarios. In recent years, due to the impact of diseases and insect infestation, and environmental damage, the natural Betula platyphylla Suk. forest in China has gradually narrowed. This study accurately predicted the potential geographical distribution of Betula platyphylla Suk. under current and future climate change scenarios, which can provide the scientific basis for the cultivation, management, and sustainable utilization of Betula platyphylla Suk. resources.
Effects of early rehabilitation in sepsis patients by a specialized physical therapist in an emergency center on the return to activities of daily living independence: A retrospective cohort study

Background Early rehabilitation allows patients to better perform the activities of daily living after hospital discharge. A specialized physical therapist has been assigned as part of the early rehabilitation, but the effectiveness of the program remains unclear. We investigated how early rehabilitation provided by a specialized physical therapist affects ADL in patients with sepsis. Methods This was a retrospective cohort study. This study’s subjects were sepsis patients who entered the advanced emergency critical care center of Shinshu University Hospital between April 2014 and March 2020. Electronic medical records were reviewed to obtain information on demographic characteristics, severity score, primary source of infection, therapeutic medication, the number of days after hospital admittance until rehabilitation begins, length of hospital stay, discharge to home, and an assessment of daily living activities for each patient. The patients were divided into two groups based on whether they were treated before or after a specialized physical therapist had been hired by the advanced emergency critical care center. Results Assigning a physical therapist to a patient significantly shortened the number of days until rehabilitation began. In a multivariable model, the strongest predictors of return to independent living after hospital discharge were (1) assigning a specialized physical therapist (odds ratio = 2.40; 95% confidence interval = 1.09–5.79; P = 0.050) and (2) the number of days until rehabilitation started (odds ratio = 0.24; 95% confidence interval = 0.08–0.76; P = 0.014). Conclusions Assigning a specialized physical therapist to sepsis patients at an advanced emergency critical care center significantly shortened the number of days until a patient can begin rehabilitation after hospital admittance and improved activities of daily living after hospital discharge. Trial registration Trial registration [University Hospital Medical Information Network Clinical Trials Registry, number UMIN000040570 (2020/5/28). ]
Tracing back variations in archaeal ESCRT-based cell division to protein domain architectures

The Endosomal Sorting Complex Required for Transport (ESCRT) system is a multi-protein machinery that is involved in cell division of both Eukaryotes and Archaea. This spread across domains of life suggests that a precursor ESCRT machinery existed already at an evolutionary early stage of life, making it a promising candidate for the (re)construction of a minimal cell division machinery. There are, however, only few experimental data about ESCRT machineries in Archaea, due to high technical challenges in cultivation and microscopy. Here, we analyse the proteins of ESCRT machineries in archaea bioinformatically on a protein domain level, to enable mechanistical comparison without such challenging experiments. First, we infer that there are at least three different cell division mechanisms utilizing ESCRT proteins in archaea, probably similar in their constriction mechanisms but different in membrane tethering. Second, we show that ESCRT proteins in the archaeal super-phylum Asgard are highly similar to eukaryotic ESCRT proteins, strengthening the recently developed idea that all Eukaryotes descended from archaea. Third, we reconstruct a plausible evolutionary development of ESCRT machineries and suggest that a simple ESCRT-based constriction machinery existed in the last archaeal common ancestor. These findings not only give very interesting insights into the likely evolution of cell division in Archaea and Eukaryotes, but also offer new research avenues by suggesting hypothesis-driven experiments for both, cell biology and bottom-up synthetic biology.
Integration of cytopathology with molecular tests to improve the lab diagnosis for TBLN suspected patients

Background Tuberculosis lymphadenitis (TBLN) diagnosis is often challenging in most resource poor settings. Often cytopathologic diagnosis of TBLN suspected patients is inconclusive impeding timely clinical management of TBLN suspected patients, further exposing suspected patients either for unnecessary use of antibiotics or empirical treatment. This may lead to inappropriate treatment outcome or more suffering of suspected patients from the disease. In this study, an integrated diagnostic approach has been evaluated to elucidate its utility in the identification of TBLN suspected patients. Methods A cross-sectional study was conducted on 96 clinically diagnosed TBLN suspected patients, where fine needle aspirate (FNA) samples were collected at the time of diagnosis. FNA cytology, Ziehl-Neelsen (ZN), Auramine O (AO) staining, GeneXpert MTB/RIF and Real time PCR (RT-PCR) were performed on concentrated FNA samples. Considering culture as a gold standard, the sensitivity, specificity, positive and negative predictive values were calculated. Cohen’s Kappa value was used to measure interrater variability and level of agreement and a P-value of <0.05 was considered as statistically significant. Result Out of the 96 FNA sample, 12 (12.5%) were identified to have Mycobacterium tuberculosis (Mtb) using ZN staining, 27 (28.1%) using AO staining, 51 (53.2%) using FNAC, 43 (44.7%) using GeneXpert MTB/RIF, 51 (53.1%) using Real time PCR (RT-PCR) and 36 (37.5%) using Lowenstein-Jensen (LJ) culture. Compared to LJ culture, the sensitivities of GeneXpert MTB/RIF, RT-PCR, and FNAC were 91.7%, 97.2%, and 97.2%, respectively and the specificities were 83.3%, 73.3%, and 68.3%, respectively. GeneXpert MTB/RIF and RT-PCR when combined with FNAC detected 61 (63.5%) cases as having Mtb, and the sensitivity and specificity was 100% and 58.3%, respectively. Conclusion FNA cytology and RT-PCR detected more TBLN cases compared to other Mtb detection tools and the detection sensitivity even improved when FNA cytology was combined with GeneXpert MTB/RIF, performed on concentrated FNA sample, suggesting the combined tests as an alternative approach for improved diagnosis of TBLN.
Pengaruh Kompetensi terhadap Kepuasan Kerja dan Work Engagement Karyawan UKM Kluster Hasil Pengolahan Perikanan di Bogor

The number of SMEs and amount of processed fish products in the city of Bogor is potential for the development of fish processing SMEs. SMEs need employees who are satisfied with their job and engaged with their work to maximize the development of their potential. The purpose of this study was to analyze the effects of competence and compensation on the job satisfaction and work engagement of employees of fish processing SMEs in Bogor. The sampling method used was a non-probability sampling technique, namely the census technique. The data processing and analysis methods were validity and reliability testing using SPSS, descriptive analysis, and Structural Equation Modeling (SEM) using SmartPLS. The descriptive analysis results showed the perceptions of employees towards competence, compensation, job satisfaction and work engagement.The SEM results show that job satisfaction was affected by competence and compensation. Work engagement was affected by competence and job satisfaction but it was not affected by compensation.