Miracle-dz/UniFAR-FTUs huggingface dataset:
A critical look at the merger scenario to explain multiple populations and rotation in iron-complex globular clusters

Merging has been proposed to explain multiple populations in globular clusters (GCs) where there is a spread in iron abundance (hereafter, iron-complex GCs). By means of N-body simulations, we investigate if merging is consistent with the observations of sub-populations and rotation in iron-complex GCs. The key parameters are the initial mass and density ratios of the progenitors. When densities are similar, the more massive progenitor dominates the central part of the merger remnant and the less massive progenitor forms an extended rotating population. The low-mass progenitor can become the majority population in the central regions of the merger remnant only if its initial density is higher by roughly the mass ratio. To match the radial distribution of multiple populations in two iron-complex GCs ({\omega} Cen and NGC 1851), the less massive progenitor needs to be four times as dense as the larger one. Our merger remnants show solid-body rotation in the inner parts, becoming differential in the outer parts. Rotation velocity V and ellipticity {\epsilon} are in agreement with models for oblate rotators with isotropic dispersion. We discuss several kinematic signatures of a merger with a denser lower mass progenitor that can be tested with future observations.
A Face-Shear Mode Piezoelectric Array Sensor for Elasticity and Force Measurement

We present the development of a 6 × 6 piezoelectric array sensor for measuring elasticity and force. The proposed sensor employs an impedance measurement technique, sensing the acoustic load impedance of a target by measuring the electrical impedance shift of face-shear mode PMN–PT (lead magnesium niobate–lead titanate) single crystal elements. Among various modes of PMN–PT single crystals, the face-shear mode was selected due to its especially high sensitivity to acoustic loads. To verify the elasticity sensing performance, gelatin samples with different elastic moduli were prepared and tested. For the force measurement test, different magnitudes of force were loaded to the sensing layer whose acoustic impedance was varied with applied forces. From the experimental results, the fabricated sensor showed an elastic stiffness sensitivity of 23.52 Ohm/MPa with a resolution of 4.25 kPa and contact force sensitivity of 19.27 Ohm/N with a resolution of 5.19 mN. In addition, the mapping experiment of elasticity and force using the sensor array was successfully demonstrated.
PREVALENCE AND ASSOCIATED FACTORS OF MUSCULOSKELETAL COMPLAINTS AMONG NURSES OF MANSOURA UNIVERSITY CHILDREN HOSPITAL

Introduction: Work-related musculoskeletal disorders (WMSDs) are described as discomforts experienced by the worker on the musculoskeletal and neurovascular systems. According to the Occupational Safety and Health Administration, nurses are in the 10 major occupations which have the high risk of work-related musculoskeletal disease. It is more relevant in less-developed countries because of prolonged hospital stays and increased patient loads. Aim of work: To estimate the prevalence of musculoskeletal complaints and its associated factors among nurses. Materials and Methods: A cross sectional study with comparative component was conducted among nurses working in Mansoura Children University Hospital during the period from January to May 2017. Data was collected using a questionnaire included personal, past and occupational histories. Furthermore, a Nordic Questionnaire was used to examine the prevalence of musculoskeletal complaints among the participants. Dutch Musculoskeletal Questionnaire was employed to study the possible associated ergonomic factors. Results: The prevalence of musculoskeletal complaints among nurses was 85.9 % . The most common sites were elbow (85.2%) followed by pelvis/thigh (74.9%) and wrist (64.6%). Surprisingly the least site for pain was low back pain (37%). This prevalence was statistically lower among age group (30- <40 years old) compared to younger age group (80.0% versus 91.2%). It increased for continuous working ≥ 6 hours and shift work with adjusted odds ratio (2.59, 2.19; respectively). Conclusion: Nearly 86% of the pediatric nurses reported 1-year prevalence of musculoskeletal complaints affecting mostly elbow, pelvis/thigh and wrists/hands. Ergonomic assessment and preventive intervention should be conducted to decrease the prevalence through improving associated occupational factors and implementing preventing programs as manual handling techniques.
Compensation schemes, liquidity provision, and asset prices: an experimental analysis

In an experimental setting in which investors can entrust their money to traders, we investigate how compensation schemes affect liquidity provision and asset prices, two outcomes that are important for financial stability. Compensation schemes can drive a wedge between how investors and traders value the asset. Limited liability makes traders value the asset more than investors. To limit losses, investors should thus restrict liquidity provision to force traders to trade at a lower price. By contrast, bonus caps make traders value the asset less than investors. This should encourage liquidity provision and increase prices. In contrast to these predictions, we find that under limited liability investors increase liquidity provision and asset price bubbles are larger. Bonus caps have no clear effect on liquidity provision and they fail to tame bubbles. Overall, giving traders skin in the game fosters financial stability.
A Drowning Sunda Shelf Model during Last Glacial Maximum (LGM) and Holocene: A Review

DOI: 10.17014/ijog.v1i2. 182Rising sea levels since the Last Glacial Maximum (LGM), some ~20,000 years ago, has drowned the Sunda Shelf and generated the complex coastal morphology as seen today. The pattern of drowning of the shelf will be utilized to assess likely timing of shoreline displacements and the duration of shelf exposure during the postglacial sea level rise. From existing sea level records around Sunda Shelf region, “sea level curve” was assembled to reconstruct the shelf drowning events. A five stage drowning model is proposed, including 1) maximum exposure of the shelf at approximately 20,500 years Before Present (y.B.P.), when sea level had fallen to about -118 m below present sea level (bpl.), 2) melt water pulse (MWP) 1A at ~14,000 y.B. P. when sea level rose to about -80 m bpl. , 3) melt water pulse (MWP) 1B at ~11,500 y.B. P., when sea level was predicted around -50 m bpl. , 4) Early-Holocene at ~9,700 y.B. P, when sea level was predicted at about-30 m bpl, and 5) sea level high stand at ~4,000 y.B. P., when sea level jumped to approx. +5 m above present sea level (apl.). This study shows that the sea level fluctuated by more than 120 m at various times during LGM and Holocene. Also confirmed that sea level curve of Sunda Shelf seems to fit well when combined with sea level curve from Barbados, although the comparison remains controversial until now due to the considerable distinction of tectonic and hydro-isostatic settings.
Technology Transfers and Knowledge Management in Developing Economies: Case Study of an Indonesian Manufacturer

Over the past 30 years research on Entrepreneurship Orientation (EO) has provided valuable information regarding strategy, entrepreneurship and aspects of performance at the firm-level. In the entrepreneurial universe, microenterprises play a very special role in the business context of the economy. However, they have not been relatively present in the EO research. This paper studies the EO-performance relationship in a group of microenterprises in Mexico and includes the Dominant Logic (DL) as a variable that moderates this relationship. The results indicate that risk taking, proactiveness and competitive aggressiveness variables from the EO influence the microenterprise performance. In addition, the external DL conceptualization moderates the EO-performance relationship. This paper shows the conclusions of the investigation as well as the limitations and identifies future research methods.
Erlotinib-loaded albumin nanoparticles_ A novel injectable form of erlotinib and its in vivo efficacy against pancreatic adenocarcinoma ASPC-1 and PANC-1 cell lines

Erlotinib was loaded on albumin nanoparticles for the first time and the cytotoxic effect of the resulting nanoparticles against ASPC-1 and PANC-1 pancreatic adenocarcinoma cell lines was evaluated. The carrier (albumin nanoparticles, ANPs) was synthesized by desolvation method using a mixed solvent followed by thermal crosslinking for stabilization. ANPs and the drug-loaded ANPs were characterized by field emission scanning and transmission electron microscopies, particle size analysis and Fourier transform infrared spectroscopy. The nanoformulation had a size of< 14 nm with a good monodispersity. Drug loading and encapsulation efficiencies were evaluated as 27 and 44%. Cytotoxicity assays after 72 h revealed the potential of ANPs to improve erlotinib toxicity (54% against 34% of free drug toward ASPC-1 cell line, and 52% against 30% toward PANC-1 cell line). Values of IC50 were obtained for both cell lines and indicated significant reduction in the erlotinib dose necessary for killing the cells, while, ANPs were completely safe. The results demonstrated that erlotinib-loaded ANPs had a remarkable potential for pancreatic cancer drug delivery.
Myeloperoxidase (MPO) and eosinophil peroxidase (EPO) effecting on asthma patients in Basra Province, Iraq

Myeloperoxidase and eosinophil peroxidase granules zurophilic proteins are a marker important in asthma patients. In the current study myeloperoxidase (MPO) and Eosinophil peroxidase levels were assessed in different stages of asthma, in 100 patients suffering from asthma, classified as (active asthma, moderate, and severe) according to diagnosis by specialist physician In addition to 20 healthy controls. Results of the current study showed mean serum level of MPO was 16.37 ± 7.78 ng/ml (median ± SD) in controls, and 39.80 ± 22.22 ng/ml in the asthma patients. According to the asthma severity MPO levels were (40.54 ± 29.92, 36.91 ± 20.18 and 34.42 ± 16.04 ng/ml) (median ± SD) in (active asthma, moderate, and severe) asthmatics patients, respectively with significant differences (P ≤ 0.05) between all type of asthma patients and healthy controls, according to asthma severity the results showed significant differences (P ≤ 0.05) between the type of asthma patients active asthma and severe asthmatics. On the other hand eosinophil peroxidase levels of EPO were 47.68 ± 5.78 ng/ml (median ± SD) in control and 75.89 ± 14.46 ng/ml in the asthmatic patients. Depending on the asthma severity, the EPO levels were 76.81 ± 11.45 ng/ml, 68.05 ± 11.29 ng/ml, 66.19 ± 11.77 ng/ml in active asthma, moderate, and severe asthmatics respectively, the results show no significant differences between the type of asthma patients (P ≥ 0.05), but show significant differences between the type of asthma patients and healthy controls and significant differences active asthma and severe asthmatics between 76.81 ± 11.45, 66.19 ± 11.77 ng/ml respectively. Results of the study showed elevated levels of both enzymatic (EPO and MPO) respectively in asthma patients with active asthma with high significant different (P ≤ 0.01) compared with controls, while the results showed serum levels of EPO higher than MPO in patients.
HOUSING WEALTH EFFECTS ON LABOUR SUPPLY: EVIDENCE FROM AUSTRALIA∗

In this study we analyse the effect of housing wealth on labour supply using Australian panel data. Wealth effects are identified from exogenous variation in local area housing prices, while controlling for variation in local labour demand conditions. The most quantitatively important responses were in labour force participation and weekly hours of work by women (both single and married), with clear life-cycle patterns. The effect for the older cohort of women is associated with early retirement for those experiencing above-average housing wealth gains. For younger women there was a reduction in hours of work in response to unexpected gains in housing wealth. The estimated wealth effects are consistent with leisure being a normal good. JEL classifications: D12, E21, J22.
Examining the Effect of Evaporation Field on Boron Measurements in SiGe: Insights into Improving the Relationship Between APT and SIMS Measurements of Boron

Abstract Understanding and resolving discrepancies between atom probe tomography (APT) and secondary ion mass spectrometry (SIMS) measurements of B dopants in Si-based materials has long been a problem for those in the semiconductor community who wish to measure B within the source/drain SiGe of a device. APT data collection of Si-based materials is typically optimized for Si, which is logical, but perhaps not ideal for field evaporation of B. Increasing the evaporation field well beyond the typically used 28Si2+:28Si+ ratio of approximately 10:1 up to a ratio of ~200:1 is demonstrated to improve B detection while retaining well-matched Si and Ge concentrations with respect to those measured by SIMS. A range of evaporation conditions are examined from a very low field with high laser energy to an extremely high field with extremely low laser energy demonstrating problems at both far ends of the spectrum and a sweet spot when the operating conditions used produce a 28Si2+:28Si+ ratio of approximately 200:1 (in terms of total counts of each ionization state), which is more than an order of magnitude higher than normally used conditions and results in nicely matched B, Si, and Ge APT measurements with those of SIMS.
Directed in Vitro Evolution of Therapeutic Bacteriophages: The Appelmans Protocol

The ‘Appelmans protocol’ is used by Eastern European researchers to generate therapeutic phages with novel lytic host ranges. Phage cocktails are iteratively grown on a suite of mostly refractory bacterial isolates until the evolved cocktail can lyse the phage-resistant strains. To study this process, we developed a modified protocol using a cocktail of three Pseudomonas phages and a suite of eight phage-resistant (including a common laboratory strain) and two phage-sensitive Pseudomona aeruginosa strains. After 30 rounds of selection, phages were isolated from the evolved cocktail with greatly increased host range. Control experiments with individual phages showed little host-range expansion, and genomic analysis of one of the broad-host-range output phages showed its recombinatorial origin, suggesting that the protocol works predominantly via recombination between phages. The Appelmans protocol may be useful for evolving therapeutic phage cocktails as required from well-defined precursor phages.
Explain This, Explore That: A Study of Parent–Child Interaction in a Children's Museum

Parents visiting a gear exhibit at a children's museum were instructed to encourage their children (N = 65; ages 4–6) to explain, explore, or engage as usual. Instructions led to different patterns of play at the exhibit: Encouragement to explain led to greater discussion of gear mechanisms, whereas encouragement to explore led to more time connecting gears. In the explain condition, parents’ questions predicted their children's discussion and further testing of gears. Questions also predicted the amount of time children spent on a follow‐up task. Parents’ exploration predicted an increase in exploration by their children. These data indicate that minimal interventions impact parent–child interaction at a museum exhibit and that prompts to explore or explain uniquely influence parent and child behavior.
Comparison of Management and Orchestration Solutions for the 5G Era

5G is considered to be the technology that will accommodate the development and management of innovative services with stringent and diverse requirements from end users, calling for new business models from the industry. In this context, the development and efficient management of Network Services (NS) serving specific vertical industries and spanning across multiple administrative domains and heterogeneous infrastructures is challenging. The main challenges regard the efficient provision of NSs considering the Quality of Service (QoS) requirements per vertical industry along with the optimal usage of the allocated resources. Towards addressing these challenges, this paper details an innovative approach that we have developed for managing and orchestrating such NSs, called SONATA, and compare it with OSM and Cloudify, which are two of the most known open-source Management and Orchestration (MANO) frameworks. In addition to examining the supported orchestration mechanisms per MANO framework, an evaluation of main operational and functional KPIs is provided based on experimentation using a real testbed. The final aim is the identification of their strong and weak points, and the assessment of their suitability for serving diverse vertical industry needs, including of course the Internet of Things (IoT) service ecosystem.
Identification of exosomal and non-exosomal microRNAs associated with the drug resistance of ovarian cancer

MicroRNAs (miRNAs) serve important roles in drug-resistance; however, exosomal miRNAs associated with drug-resistance in ovarian cancer (OC) have not been reported to date. The current study aimed to analyze the drug resistance-associated exosomal miRNAs in original OC cells and their derived exosomes using microarray data downloaded from the Gene Expression Omnibus database (series GSE76449). The chemosensitive OC cell lines SKOV3_ip1, A2780_PAR and HEYA8, as well as the chemoresistant cell lines SKOV3_TR, A2780_CP20 and HEYA8_MDR, were investigated. Differentially expressed miRNAs (DE-miRNAs) were identified using the limma method, and their mRNA targets were predicted using the miRWalk and LinkedOmics database. Functions of target genes were analyzed with DAVID tool, while TCGA data were used to explore the survival association of identified miRNAs. According to the results, 28 DE-miRNAs were found to be common in exosomal and original samples of A2780_CP20 cells, among which the functions of 5 miRNAs were predicted (including miR-146b-5p, miR-509-5p, miR-574-3p, miR-574-5p and miR-760). In addition, 16 and 35 DE-miRNAs were detected for HEYA8_MDR and SKOV3_TR, respectively, with the functions of 4 of these miRNAs predicted for each cell line (HEYA8_MDR: miR-30a-3p, miR-30a-5p, miR-612 and miR-617; SKOV3_TR: miR-193a-5p, miR-423-3p, miR-769-5p and miR-922). It was also reported that miR-183-5p was the only one common miRNA among the three cell lines. Furthermore, miR-574-3p, miR-30a-5p and miR-922 may regulate CUL2 to mediate HIF-1 cancer signaling pathway, while miR-183-5p may modulate MECP2, similar to miR-760, miR-30a-5p and miR-922, to influence cell proliferation. Finally, the downregulated miR-612 may promote the expression of TEAD3 via the Hippo signaling pathway, and this miRNA was associated with poor prognosis. In conclusion, the findings of the present study suggested several underlying miRNA targets for improving the chemotherapy sensitivity of OC.
Time-resolved dissection of the molecular crosstalk driving Fusarium head blight in wheat provides new insights into host susceptibility determinism.

Fungal plant diseases are controlled by a complex molecular dialogue that involves pathogen effectors able to manipulate plant susceptibility factors at the earliest stages of the interaction. By probing the wheat-Fusarium graminearum pathosystem, we profiled the coregulations of the fungal and plant proteins shaping the molecular responses of a 96-hr-long infection's dynamics. Although no symptoms were yet detectable, fungal biomass swiftly increased along with an extremely diverse set of secreted proteins and candidate effectors supposed to target key plant organelles. Some showed to be early accumulated during the interaction or already present in spores, otherwise stored in germinating spores and detectable in an in vitro F. graminearum exudate. Wheat responses were swiftly set up and were evidenced before any visible symptom. Significant wheat protein abundance changes co-occurred along with the accumulation of putative secreted fungal proteins and predicted effectors. Regulated wheat proteins were closely connected to basal cellular processes occurring during spikelet ontogeny, and particular coregulation patterns were evidenced between chloroplast proteins and fungal proteins harbouring a predicted chloroplast transit peptide. The described plant and fungal coordinated responses provide a resourceful set of data and expand our understanding of the wheat-F. graminearum interaction.
Yield Loss Assessment of Barley Yellow Dwarf Disease on Spring Oat in Illinois.

The quantitative relationship between yield of spring oat cvs. Ogle and Noble and incidence of barley yellow dwarf (BYD) disease caused by barley yellow dwarf virus (BYDV-PAV-IL) was studied. Field plots were infested with Rhopalosiphum padi vectoring BYDV-PAV-IL. A linear critical point regression model was developed that related percentage of maximum yield to BYD incidence, assessed by estimating the percentage of plants with BYD symptoms at Feekes growth stage 10.5 in each plot. The model y = 96.9 - 0.45x (r2 = 0.53) best explained the relationship. Test weight was unaffected by BYD. Although Noble consistently sustained higher disease incidence than Ogle, covariate analysis indicated that the effect of BYD on yield was similar for both cultivars. Studies of random versus focus inoculation of Noble oat, designed to determine the importance of compensation in reducing yield loss associated with BYD, indicated that compensation did not play an important role.
Is There a Paradox of Pledgeability?

Abstract We show that in the limited-commitment framework of Donaldson et al. (2019), firm value always increases in the fraction of cash flows that can be pledged as collateral. That is, pledgeability increases investment efficiency and relaxes a firm’s financing constraint. We derive this conclusion using the same contracts considered by the authors and generalize the result to an arbitrary number of states. We also show that the first best can always be implemented by a nonstate-contingent secured debt contract, which differs from the ones they consider.
Propolis Microgel as Protective Agent for Odontoblast Cell in External Bleaching

To evaluate the effects of 10% propolis microgel (PM) on the MDPC-23 odontoblast cell line viability in external bleaching. The cells were seeded in well plate with Dulbecco’s Modified Eagle medium (DMEM) and incubated for 48 hours. Enamel dentin disc is placed in acrylic transwell above the MDPC-23 odontoblasts cell line and slightly contacted with the cells in well plate. 40% Hydrogen peroxide (H2O2) and 10% propolis microgel were applied over enamel-dentin disc during treatment. Six groups of cells (n=10) were treated as follows: P0: no treatment (control); P1: H2O2 /20 min; P2: H2O2 /20 min, flushed, incubated/30 min; P3: H2O2 /20 min, flushed, PM/30 min; P4: PM/30 min, flushed, H2O2 /20 min; and P5: PM/30 min. The cell viability was evaluated by MTT assay. The data obtained were analyzed by ANOVA test (α=0.05). The percentages of cell viability were as follows: P0 (control)= 69.063%; P1=23.844%, P2=31.579 %, P3=50.964 %, P4=53.349 %, and P5=57.628 %. Group P3 and P4 presented a statistically higher cell viability than did group P1 and P2. PM decreased cell death percentage caused by H2O2, demonstrating its protective effect against the toxic components of this bleaching agent. It was concluded that 10% propolis microgel could maintain the viability MDPC-23 odontoblastic cells, so it can be used to protect these cells against the cytotoxic effects of H2O2. Experimental article (J Int Dent Med Res 2019; 12(4): 1343-1347)