Miracle-dz/UniFAR-FTUs huggingface dataset:
DUAL HER2 BLOCKADE WITH TRASTUZUMAB AND PERTUZUMAB IN HER2-POSITIVE BREAST CANCER: SINGLE CENTER REAL WORLD DATA

Agents targeting the human epidermal growth factor receptor 2 (HER2) have improved outcomes of advanced HER2-positive breast cancer with durable responses. We evaluated therapy with trastuzumab and pertuzumab in early and metastatic HER2-positive breast cancer patients. In this paper we discuss the practicalities of treating patients with this combination with a particular focus on treatment in the single center setting. We retrospectively identifed patients on adjuvant and frst-line anti-HER2 therapy at The University Clinic of Radiotherapy and Oncology Skopje for at least 1 year from 2019 to 2020. Demographics, treatments and adverse events were recorded. The combination of pertuzumab–trastuzumab has established efficacy in patients with HER2‐positive advanced/metastatic breast cancer. Management of treatment related side‐effects such as diarrhea, febrile neutropenia and neuropathy typically include dose reduction or switching taxane. Specific patients with poorer tolerance of chemotherapy such may require particular management strategies. The roles of trastuzumab and pertuzumab are now very well established in the frst-line setting; identifying predictors of long-term response to these would be important in selecting which patients might beneft from entry into future clinical trials assessing the long-term beneft of these newer agents in addition.
Comparison of intravenous paracetamol vs. intramuscular diclofenac for postoperative pain control in abdominal hysterectomy

Innervation of the urogenital tract is complex and made up of somatic, sympathetic and parasympathetic components, found along the lateral walls of the pelvis. The nerves and nerve plexuses in the pelvis innervate the organs of the pelvis through the ligaments that anchor the various organs to the pelvis. Innervation to the uterus, ovaries, and vagina is derived from the superior hypogastric, pelvic, and uterovaginal plexus. Hysterectomy is the second most frequently performed major surgical procedures on women all over the world, next only to caesarean section. In US, approximately 600,000 hysterectomies are performed each year. In India, no national statistics for hysterectomy is available. A study conducted in a northern state of India (Haryana) states that incidence of hysterectomy was 7% among married women above 15 years of age. Another study from a western state (Gujarat) pointed out that 7-8% of rural women and 5% of urban women had already undergone hysterectomy at an average age of 37 years. Indications of hysterectomy vary from genital ABSTRACT
Critical Thinking: Components, Skills, and Strategies

The research paper aimed at uncovering the components of critical thinking and identifying critical thinking skills and strategies by analyzing the relevant sources and inferring the components, skills and strategies for critical thinking. It came up with a number of components of critical thinking as well as certain skills. It is noticed that most critical thinking skills revolve around skills of the Watson-Glaser model. The study also found the most important strategies for teaching critical thinking. The study indicated the importance of designing training programs for teachers in employing critical thinking skills in the educational process.
Protection of Geographical Indications of Goods of Bangladesh

The protection of Geographical Indications (GIs) of goods has attracted much attention from the countries around the world in the wake of increased interest of consumers for origin labeled products or goods. This study aims -at unearthing various protection systems in vogue in countries to prescribe one particular system for a typical agrarian developing country like Bangladesh. In course of investigation it has been revealed that almost all the countries protect their GIs either under sui-generis system or under certzjkation trademark (CTM) system. The advantages and disadvantages considered, the study found that sui-generis system has some benefits like strengthening of farmers' position, potential for rural development, superior quality maintenance of goods etc., while CTM system has its own strong points as it ensures market oriented approach, encourages more private initiative andpromotes corporate branding of goods etc. in Glprotection. Considering merits and demerits of both the system for a typical developing country it was shown that it depends on the development policy priority of a country to choose either of the two. If the country wants to strengthen the position of farmers, boost rural economy through GI protection, then it may veiy well go for Sui-generis system of protection. On the other hand, if the country intends to introduce corporate control of agriculture, increase quantity of goods while giving less attention on quality, then CTM system seems appropriate. The case of Bangladesh has been examined separately with the touchstone of a typical developing country and it was revealed that with some empirical studies done, Bangladesh may rather choose sui-generis system for protection of its GIs. Assistant Dircctor, Bangladesh Public Administration Training Centre 64 Bangladesh Journal of Public Administrat ion
The relationship between physical activity levels and health-related quality of life in elderly individuals aged 65 years and above with a chronic disease

Background: Chronic diseases are the leading cause of death worldwide with increasing prevalence in the population aged 65 years and above. This study aimed to evaluate the relationship between physical activity level and health-related quality of life in elderly individuals. Material and methods: The participants aged 65 years and older (46 males and 35 females) were divided into 3 groups according to their physical activity levels: low physical activity (<150 minutes/week), moderate physical activity (150–300 minutes/week) and high physical activity level (>300 minutes/week). Health-related quality of life (HRQoL) was calculated using EQ-5D scale. Spearman's correlation coefficient was used to determine the relationship between physical activity level and HRQoL scores in elderly individuals. Results: A significant relationship and differences were found between high, moderate and low physical activity levels and HQQoL dimensions (P<0.05). The moderate and high physical activity groups were found to be significantly higher in all dimensions compared to the low physical activity group according to HRQoL scores (P<0.001). Conclusions: It has been concluded that high and moderate physical activity levels have a great positive relationship with HRQoL in individuals aged 65 years and older with a chronic disease.
Metamemory-Memory Behavior Relationship: An lntegrative Review*

Since the beginning of the 1970s, increasing attention has been directed toward the development of children's awareness of their own memory. This phenomenon has been termed metamemory by John Flavell (1971), who broadly defined it as the individual's potentially verbalizable knowledge concerning any aspect of inforrnation storage and retrieval. Whereas the interest in metamemory development has been growing rapidly since then, documenting the construct's general usefulness in a wide area of different memory situations, there are at least two critical points that deserve special consideration: (1) the conceptualization of the construct and (2) its status as a predictor of actual memory behavior. While the latter is the topic of the present chapter and is discussed in more detail, we first concentrate on some problems related to the definition of metamemory. The first taxonomy of classes of memory knowledge was provided in the metamemoryinterview study by Kreutzer, Leonard, and Flavell (1975).
Factors Associated with Incident Cardiovascular Events and Cardiac Risk Assessment in a Cohort of HIV-infected Participants in Rio de Janeiro

Background: Cardiovascular events (CVEs) have emerged as an important cause of morbimortality in people living with HIV/AIDS (PLHA). We aimed to investigate factors associated with incident CVE and compare the observed incidence with the predicted CVE risk by three different equations. Methods: Among the 649 active participants of the INI-ELSA cohort, we analysed data of 644 individuals free of CVE at baseline examinations. We used Cox regression models to study factors associated with CVE and to assess the equation's performance we compared the observed incidence with the overall 5-year predicted risks. Results: Over a median follow-up of 6.26-years (interquartile range [IQR] 6.01-6.47), there were 18 CVE, four deaths. Overall, 57.92% were male, median age was 43.4 years (35.82-50.73), most were on cART (88.65%). Participants who had CVE were older, had poorer renal function, higher proportion of dyslipidemia and higher levels of systolic blood pressure and triglycerides. The observed CVE rate was 2.90% (1.60-4.90%) whereas their overall cardiovascular disease (CVD) risk differed depending on which score was used: 0.91 (0.42-20), 1.16 (0.38-2.78) and 1.68 (0.60-3.87), according to Framingham, ASCVD and DAD, respectively. In the multivariable Cox analysis black race, smoking 10+ packs years, dyslipidemia, current CD4 cell count x101, cumulative viral load and time on NNRTI were independent predictors of CVE. Conclusion: Both traditional and HIV-related factors were associated with incident CVE. Risk scores were inconsistent in classifying patients who had CVE as high risk, indicating that validation studies are required to improve risk assessment of PLHA in Brazil.
Occurrence of vaginal infection (volvovaginities) among female students in Ogun State College of Health Technology, Ilese-Ijebu, Ogun State, Nigeria

Volvovaginitis is an inflammation of the vagina that can result in discharge, itching and pain. This study determined the occurrence of vaginal infection (volvovaginitis) among female students in Ogun State College of Health Technology, Ilese-ijebu. A validated questionnaire was used to obtain information on socio-demographic characteristics of fifty selected students and sterile swab stick was used to collect their vaginal swabs. MacConkey and Chocolate agar were used to culture the microorganisms and data were analyzed using frequency counts, percentages, correlation, and ChiSquare. The result showed that majority of the students were in the age range of 21-25yrs and the hygienic practices of the students were poor because majority do not have access to clean water, about 45% spread their underwear in untidy environment after washing, 27% of them used any material (clothe, tissue paper, cotton wool) during their menstrual period if they could not afford sanitary pad at that moment and 15% confessed that they can wear their pants for two or three days. The isolated microorganisms showed the growth of Candida spp, Staphylococcus aureus, Klebsiella and Escherichia coli in 40%, 22% and 2% of the female students respectively. Chi-square showed a significant association between age and Candida spp (p=0.012), and Escherichia coli (p=0.004) while correlation shows a significant relationship between hygienic practices and identified microorganisms because unclean water was related to Klebsiella (p= 0.311) while dirty underwear have a significant relationship with S. aureus (p= 0.121). Conclusively, this study shows the prevalence of vaginal infections amongst female students in the college and could provide important epidemiological data on vaginal infection for future population-based studies.
A Stylistic Analysis of Some Linguistic Devices in Newspaper Headlines: Nigerian Newspapers as A Case Study

Media houses have played significant roles in national development. They, among other roles, serve as the intermediary between the government and the masses. The choice they make in their reportage begins from the headlines which may or may not outrightly show the direction of the news. The study examines the linguistic features of the news headlines on fuel subsidy removal and electricity tariff hike in Nigeria. Register analysis is the theory adopted to carry out the study. This is to enable us consider the functions of the chosen linguistic items within the social setting; find out the similarities and differences that exist among the headlines in terms of how they are structured and point out the implied meaning in them. This study, among other findings, reveals that most of the newspaper headlines on fuel subsidy removal and electricity tariff hike relied heavily on positive adjectives to palatably present government policies, actions and steps to the masses. This paper suggests that researchers could adopt Speech Act Theory to analyse the newspaper headlines on fuel subsidy removal and electricity tariff hike so as to find out what journalists are doing with words.
Thermodynamische und numerische Untersuchung eines neuartigen Sorptionszyklus zur Anwendung in Adsorptionswärmepumpen und -kältemaschinen = Thermodynamic and numerical investigation of a novel sorption cycle for application in adsorption heat pumps and chillers

Beim neuartigen Stratisorp-Zyklus kann durch Integration eines thermischen Schichtspeichers in den Zyklus die interne Warmeruckgewinnung verbessert werden. Dies erhoht die Effizienz, z. B. bei Gaswarmepumpen zur Beheizung von Gebauden. In dieser Arbeit wurden zwei Modelle zur energetischen und entropischen Analyse und eine neue Methode zur konsistenten Berechnung der Warmekapazitat des Adsorbats entwickelt. Damit wurden umfangreiche Systemuntersuchungen durchgefuhrt.
Nutritional Status and Lifestyle of the Oraon Scheduled Tribe Population of North 24 Parganas, West Bengal, India

Please cite this article as: Kundu Chowdhury T. , Das B. M. , and Roy S. K. , Nutritional Status and Lifestyle of the Oraon Scheduled Tribe Population of North 24 Parganas, West Bengal, India. Antrocom J. of Anthropology 16-2 (2020) pp. 301-313. 1Cultural Research Officer, Cultural Research Institute, Kankurgachi, Kolkata; 2Assistant Professor, Department of Anthropology, Haldia Government College, Debhog, Purba Medinipur, West Benga; 3Professor, Biological Anthropology Unit, Indian Statistical Institute, Kolkata,* Corresponding author: Tanaya Kundu Chowdhury <tanayakunduchowdhury@gmail.com> Nutritional Status and Lifestyle of the Oraon Scheduled Tribe Population of North 24 Parganas, West Bengal, India
Object Relations and Vulnerability to Substance Abuse Relapse Among Substance Abusers Visiting Narcotics Anonymous Centers in Qom City, 2018

Background: Substance abuse is a chronic disorder that has been a major social problem in most countries in recent decades. This study aimed to investigate the object relations and vulnerability to substance abuse relapse among addicts visiting Narcotics Anonymous Centers. Methods: In a cross-sectional study, 385 addicts who visited Narcotics Anonymous Centers in Qom city were entered. A demographic questionnaire, Timeline Followback Interview, and Bell Object Relations Inventory were used to gather the required data and SPSS-21 was used to analyze the data. Results: In general, 61.5 and 92.2 percent of participants were married and employed, respectively. There was a significant positive relationship between subscales of alienation, insecure attachment, egocentricity (p< 0.001), and vulnerability to substance relapse. Conclusion: According to findings, it seems that patterns of relation with initial objects and damages incurred by failure in objects-driven need expressions may have deep effects on people’s future life trajectories, mainly substance abuse and its relapse.
Skin Lesion Classification Based on Deep Convolutional Neural Networks Architectures

Skin cancer is among the primary cancer types that manifest due to various dermatological disorders, which may be further classified into several types based on morphological features, color, structure, and texture. The mortality rate of patients who have skin cancer is contingent on preliminary and rapid detection and diagnosis of malignant skin cancer cells. Limitations in current dermoscopic images, including shadow, artifact, and noise, affect image quality, which may hamper detection effort. Attempts to overcome these challenges have been made by analyzing the images using deep learning neural networks to perform skin cancer detection. In this paper, the authors review the state-of-the-art in authoritative deep learning concepts pertinent to skin cancer detection and classification.
The Effect of Attributional Style on Career Exploration of Vocational School Students: The Mediating Role of Career Decision Self-Efficacy

The purpose of this research is to examine the career exploration of vocational school students that is affected by attributional style through the mediating role of career decision self-efficacy. A total of 862 vocational school students were involved during the time span of this research. The results supported the mediation model that career decision self-efficacy mediate the effects of attributional style on career exploration of vocational school students. Respondents who applied optimistic attributional style have high career decision self-efficacy that affect their engagement in career exploration. The results also showed that attributional style can directly have an effect on career exploration of vocational school students. The results have theoretical and practical implications for further research, counseling and intervention programme.
JuKu STUDENTS ’ ACCEPTANCE OF USING A FLIPPED STEM CLASSROOM ENGINEERING-BASED MODULE *

This study aims to identify the students’ acceptance of using a Flipped STEM classroom (FSC) Engineering-based module. The study sample consisted of 120 students from the seventh grade in a private school in Jordan. A questionnaire was employed in this study. The unified theory of acceptance and use of technology (UTAUT) was used in this study to determine the extent of students' acceptance of the FSC engineering-based module. The results showed that the students’ acceptance to use the FSC engineering-based module was high. the results showed that students had more level of acceptance for performance expectancy and effort expectancy dimensions. The study recommends submitting the FSC engineering-based module for enhancing problem-solving skills for elementary school students in STEM subjects.
The Evaluation of Atypical Antipsychotic Augmentation with Atomoxetine in the Reduction of Negative Symptoms in Patients with Schizophrenia: A Randomized, Double- Blind, Placebo-Controlled Clinical Trial

Background and purpose: Schizophrenia is one of the most severe psychiatric disorders with a chronic and debilitating condition. Negative symptoms are common in patients with schizophrenia that have not yet responded well to drugs. The aim of this study is to evaluate the effect of adding Atomoxetine to atypical antipsychotics in reducing the negative symptoms in schizophrenic patients. Materials and methods: In this randomized, double-blind, placebo-controlled clinical trial during 2018-2020, 60 DSM-V based schizophrenic patients were enrolled to the study. They were divided into case (n=30) and control (n=30) groups. Case group received Atomoxetine, 40 mg daily in the first week and 40 mg daily in the following weeks and the control group received placebo. The effect of medication on negative symptoms in both groups was compared by PANSS scale at baseline and weeks 4 and 8. The data analyzed by using SPSS software version 22. Result: The mean age of the patients was 30.00 ± 8.50 years and the majority of patients were male (55%). There was no statistically significant difference between the negative symptoms of case and control group at the beginning of the study (19.86 ± 3.00 vs. 20.83 ± 3.51 p=0.257) and in the fourth week (16.53 ± 2.56 vs. 17.46 ± 3.00 p=0.201). But in the eighth week, general (26.90 ± 5.33 vs. 31.50 ± 7.41 p=0.008), negative (11.83 ± 1.87 vs. 15.83 ± 2.98 p=0.001), and Total symptoms (52.16 ± 8.33 vs. 62.33 ± 9.37 p=0.002) were significantly lower in the case group than in the control group. Conclusion: This study showed that Atomoxetine significantly reduces the negative, general and total PANSS score in schizophrenic patients. This can improve treatment and quality of life in these patients. Therefore, the findings of this study confirmed the addition of Atomoxetine to the treatment of schizophrenia to improve treatment of negative symptoms.
Effect of Parameter Variation on the Viscosity of Ethanol Gel Propellants

This research investigated how the variation of temperature and shear rate affects the viscosity of ethanol gel propellants that use methyl cellulose as gellant and, in parts, use boron as energetic additive. Using a rotational viscometer in a cone-and-plate configuration, propellant viscosity data was recorded across a range of temperatures and applied shear rates. The temperature dependence of the viscosity was modelled using an Arrhenius-type equation. For the high shear rates, the data was modelled using the Power Law, Herrschel–Bulkley model, Carreau model, and Cross model. For low shear rates the used model was the rearranged Herrschel–Bulkley model. The temperature investigation suggested that the trend of decreasing viscosity with increasing temperature, predicted by the Arrhenius-type equation, is only applicable until approximately 320 K, after which the gel viscosity increased strongly. At high shear rates, the gel behaved in a shear thinning manner and was modelled most accurately by the Cross model. At low shear rates, the gel was shear thickening up to its elastic limit, which was found to lie at 0.41 s–1.
Co-targeting myelin inhibitors and CSPGs markedly enhances regeneration of GDNF-stimulated, but not conditioning-lesioned, sensory axons into the spinal cord

A major barrier to intraspinal regeneration after dorsal root (DR) injury is the DR entry zone (DREZ), the CNS/PNS interface. DR axons stop regenerating at the DREZ, even if regenerative capacity is increased by a nerve conditioning lesion. This potent blockade has long been attributed to myelin-associated inhibitors and (CSPGs), but incomplete lesions and conflicting reports have prevented conclusive agreement. Here, we evaluated DR regeneration in mice using novel strategies to facilitate complete lesions and analyses, selective tracing of proprioceptive and mechanoreceptive axons, and the first simultaneous targeting of Nogo/Reticulon-4, MAG, OMgp, CSPGs, and GDNF. Co-eliminating myelin inhibitors and CSPGs elicited regeneration of only a few conditioning-lesioned DR axons across the DREZ. Their absence, however, markedly and synergistically enhanced regeneration of GDNF-stimulated axons, highlighting the importance of sufficiently elevating intrinsic growth capacity. We also conclude that myelin inhibitors and CSPGs are not the primary mechanism stopping axons at the DREZ.
Spatial representations in macaque hippocampal formation

The hippocampal formation is linked to spatial navigation but direct evidence in primates during active, unconstrained navigation is lacking. Combined with accurate behavioral tracking of eye and head, we record neurons across hippocampal regions in rhesus macaques during free foraging in an open arena. We find that neurons encode a broad spectrum of spatial variables beyond place fields. Most neurons show mixed selectivity, with diverse representations covering the entire space. The allocentric 15 representations are dominated by facing location and tilt orientation, and a rather low fraction of neurons shows place or grid fields. Spatial facing selectivity mainly reflects head-, rather than gaze-related, properties. These findings reveal that the macaque hippocampal formation represents space using a multiplexed code, with heading properties dominating over simple place coding during free behavior.