Miracle-dz/UniFAR-FTUs huggingface dataset:
Stable‐Carbon Isotope Variability in Tree Foliage and Wood

This study documents variation of stable-carbon isotope ratios (13C/'2C) in trees of genera Juniperus and Pinus under field conditions. Results are from cellulose analysis on leaves, twigs, and wood from a number of localities in the southwestern United States. Substantial variability, typically 1-3%oc, exists among leaves, within wood (radially, vertically, circumferentially), and between individuals at a site. These results may help guide sampling in tracer-type studies with stable-carbon isotope ratios and aid in the interpretation of isotopic results from such studies.
Survey of rats and mice and their ectoparasites in relation to cultivated areas in the vicinity of Alexandria governorate, Egypt

SUMMARY Six species and subspecies of rats and mice, Arvicanthis niloticus, Rattus norvegicus, R. rattus frugivorus, R. rattus alexandrinus, R. rattus rattus, and Mus musculus, were found associated with cotton, wheat, maize, sugar-cane, vegetables, fruit and berseem in the vicinity of Alexandria, Egypt. A. niloticus comprised 42·2% of all species collected. Maize, wheat, cotton and berseem were infested most. The lowest infestation was recorded in the fruit fields. Infestation in sugar-cane and vegetables was intermediate. R. norvegicus, M. musculus, R. rattus frugivorus, R. rattus alexandrinus and it. rattus rattusformed 23·9, 16·7, 10·4, 4·2 and 2·7% of the species collected respectively. Of the seven crops investigated, only two (cotton, wheat) were not infested with R. rattus rattus, but all were plagued with some species of rodents. The abundance of these rodents in fields seemed to be positively correlated with temperature and relative humidity. Winter represents a definite off-season for all species recorded. Six species of fleas (Xenopsylla cheopis, Nosopsyllus fasciatus, Ctenocephalides felis felis, Leptopsylla segnis, Pulex irritans and Echidnophaga gallinacea), three of sucking lice (Polyplax abyssinica, P. spinulosa and Hoplopleura capitosa), five of parasitic mites (Ornithonyssus bacoti, Laelaps echidnina, L. keegani, Androlaelaps zulu and Haemolaelaps sp.) and the tick Rhipicephalus sanguineus sanguineus were recovered from the rodents. Fleas (especially X. cheopis) and lice generally showed a certain degree of host specificity. A close relationship has been shown to exist between the abundance of fleas and lice and the abundance of some rodent hosts and climate. However, no definite host specificity or relation to climate was shown by infestation with mite species. Only B. sanguineus sanguinetie was recovered from S. rattus frugivorus during July, October and December; from R. rattus alexandrinus during November; and from R. rattus rattus during September. Its rate of infestation did not exceed one specimen per rodent host.
Implementation of Universal Tumor Screening of Colorectal Cancer for Detection of Lynch Syndrome at a Hispanic-Rich County Hospital.

INTRODUCTION In 2014, a reflexive screening protocol for Lynch syndrome (LS) via an immunohistochemistry (IHC) assay was shown to be cost-effective; however, the screening rates at a predominant Hispanic-rich institution are unclear. We hypothesized that implementation of a universal tumor screening (UTS) protocol requiring screening for LS via IHC in patients with newly diagnosed colorectal cancer (CRC) at our Hispanic-rich institution would improve detection of LS by increasing screening rates. METHODS AND MATERIALS This is a retrospective analysis of screening rates of 3 sequential cohorts of newly diagnosed patients with CRC between January 2012 and April 2016 at the University Health System and with follow-up at National Cancer Institute-designated Mays Cancer Center at University of Texas Health San Antonio. Cohort 1 consisted of patients screened using old screening guidelines (PRE). Cohort 2 consisted of patients screened when treating clinicians were receiving education on the new protocol (PERI). Cohort 3 consisted of patients screened after implementation of the UTS protocol (POST). RESULTS The majority of 312 patients were Hispanic (62.5%), 18.1% were < 50 years, and 81.9% were ≥ 50 years of age (median age, 57 years). Of patients with CRC screened for LS via IHC, the PRE, PERI, and POST cohorts had screening rates of 31%, 64%, and 58%, respectively. We found significant differences when comparing the PRE with POST sequential cohorts (P < .01). CONCLUSION The quality of Lynch syndrome-related family histories and screening rates were significantly improved after implementation in our Hispanic-rich population. Future studies are warranted to provide insight into clinical effects of increased screening, provider and patient surveillance, and screening-related systemic barriers.
Patient Perceptions of Gout Management Goals

In this cross-sectional internet survey of subjects (n=320) who visited the Gout and Uric Acid Education Society’s website, they were asked about their perception of goal for the treatment of gout. Patient identification of symptoms of gout and serum uric acid control were recognized among these subjects as the most important treatment goals. This information may be useful to establish proper guidelines. Supplemental digital content is available in the text. Objective To assess patient perceptions of gout management goals. Methods We conducted a cross-sectional Internet survey of people who visited the Gout and Uric Acid Education Society’s website to assess patient/respondent perception of gout management goals. We used chi-square test for categorical or t-test for continuous variables. Results Among the 320 survey respondents with physician-diagnosed gout, mean age was 57 (SD, 13.4) years, 72% were male, 77% White; mean gout duration was 7.6 years (SD, 11), gout flares in the last year were 5.2 (SD, 6.1), and medical comorbidities were common, 2.7 (SD, 2.6). Two-thirds respondents each reported very severe or severe symptoms from gout and that gout ranked among the top two health conditions with a negative impact on quality of life. During a clinic visit, only one-third of respondents’ physicians spent 50% of more of the time discussing gout treatment. Only 54% respondents were prescribed ULT by their healthcare provider. By patient preference, the best life-long gout treatment strategies were the lowering of the serum urate level and the control of gout symptoms (62%) followed by serum urate lowering (32%). Respondents considered the following as the most important things for making gout treatment satisfactory: (1) patient education; (2) effective physician–patient communication; (3) diet and lifestyle modification; (4) serum urate monitoring and target achievement; (5) pain management and flare prevention; and (6) medication management. Conclusions Patient identification of gout symptom control and serum urate level monitoring as the most important treatment goals is informative for clinicians and guideline developers.
Are patients with systemic lupus erythematosus at increased risk for COVID-19?

The global health emergency generated by the SARS-CoV-2 outbreak has complicated the management of patients with comorbidities, which together with old age seem to be the strongest predictor of mortality from COVID-19.1 We read with great interest the letter published by Mathian and colleagues about the clinical course of COVID-19 in patients with systemic lupus erythematosus (SLE) treated with hydroxychloroquine.2 Their preliminary data seem to suggest a particularly high incidence of severe and even fatal cases of infection, confirming that, despite ongoing treatment with antimalarial drugs, patients with SLE have a high risk of unfavourable course during the current pandemic. The critical point that remains to be clarified at present is the real incidence of COVID-19 in patients with SLE, regardless of the current treatment. Being operative in the maximum epicentre of the outbreak in Italy (Milan, Lombardy), we have had to face in these weeks the emergency related to the management of …
A Medication Management Intervention for Patients and Families with SCI and ABI

The purpose of this study was to develop and test the efficacy of a pre-discharge, medication management intervention to improve perceived knowledge and perceived confidence for post-discharge medication management for rehabilitation patients with spinal cord injuries (SCIs) and families of patients with SCIs or acquired brain injuries (ABIs). We used a quasi-experimental, matched-pair design. Treatment participants (n = 112) completed the intervention with pre- and post-tests assessing perceived knowledge and perceived confidence for post-discharge medication management. Control participants (n = 95) enrolled at 60-days post-discharge. All participants (N = 207) completed measures on perceived knowledge, perceived confidence, and medication management by phone at 60-days post-discharge. The intervention significantly increased treatment participants’ perceived knowledge and perceived confidence from pre- to post-test. Sex, injury severity, and income were associated with primary outcomes. Treatment participants used more tools for medication management post-discharge. Our findings suggest that patients and family members may benefit from pre-discharge medication management interventions.
Apparent survival rates of two Sylvia warbler species in northwestern Russia

Mark–recapture ringing data from two sites in northwestern Russia were used to estimate apparent survival rates in populations of Garden Warbler Sylvia borin and Whitethroat S. communis. The computer program MARK was used to estimate survival and recapture rates, adjusted for transient birds, with respect to sexes at each site. Survival rate of Garden Warbler was higher than that of Whitethroat. This difference may reflect the habitat preferences of these species. Survival of Garden Warbler was similar between sexes; females of Whitethroat did not return to the study sites.
Insect resistance in recombinant inbred soybean lines derived from non‐resistant parents

Larval performance of Helicoverpa zea (Boddie) (corn earworm) (Lepidoptera: Noctuidae) was examined on 240 recombinant inbred (RI) soybean, Glycine max (L.) Merrill, lines. These homozygous RI were derived from an intraspecific cross of genetically distant, non‐resistant, parents, Minsoy from China and Noir 1 from Hungary. Based upon a genetic map of more than 500 molecular markers, each RI line presented a unique genotype composed of a mixture of different parental alleles. The RI lines exhibited transgressive segregation with respect to their defensive effects on H. zea, such that the range of RI phenotypes far exceeded that of the parents. Similar effects were observed on the soybean looper, Pseudoplusia includens (Walker) (Lepidoptera: Noctuidae). We identified several independent quantitative trait loci (QTLs) linked to molecular markers that were associated with H. zea larval development parameters. Two QTLs affected several different traits including larval weight and developmental rate; other QTLs affected only a single trait each, i.e., larval weight, pupal weight, developmental rate, nutritional efficiency or survival. The results demonstrate that the increased range of defensive effects among the segregant RI lines is due to recombination among several parental genes that together quantitatively control plant defensive traits.
Variabilidade espacial de atributos químicos em latossolo e argissolos

The objective of this research was to characterize the spatial variability of chemical attributes of soils cultivated with sugarcane in areas with variations in relief forms. The two soils studied were a Latosol, placed in a convex landform (158ha), and an Argisol, placed in a linear landform (172ha). Soil samples for chemical analysis were collected in a regular grid, at the depth of 0.0-0.5m. The convex landform presented the highest coefficient variation and ranges. Therefore, the Latosol inserted in the landform convex presented greater spatial variability for chemical attributes than the Argisol in the linear landform. A larger number of points must be sampled in order to represent the spatial variability of the Latosol from the convex landform. We recommend the sampling interval to be equal to the range of the spatial dependency in order to associate a less intensive sampling effort with a higher representativity.
Association of total sugar content with other seed traits of diverse soybean cultivars.

Total sugar content of soybean [Glycine max (L.) Merr. ] seeds is considered to be important for the quality of some soyfoods. The objective of this study was to determine the association of total sugar with other seed traits of soybean to facilitate the development of cultivars with appropriate seed composition. Total sugar, protein, oil, fiber, and seed size of 23 conventional and food-grade cultivars were evaluated in replicated tests at eight Iowa locations in 1998. Total sugar content was determined by acid hydrolysis, and protein, oil, and fiber were measured by near-infrared reflectance (NIR). There were significant differences among the cultivars for all traits. Total sugar was most highly correlated (-0.81) with the sum of protein + oil (P + O). Seed size had a major influence on the association of total sugar with protein, oil, and fiber individually. Analysis of P + O by NIR was not influenced by seed size and should be a useful method of predicting differences among genotypes for total sugar content.
Saccade dysmetria indicates attenuated visual exploration in autism spectrum disorder.

BACKGROUND Visual exploration in autism spectrum disorder (ASD) is characterized by attenuated social attention. The underlying oculomotor function during visual exploration is understudied, whereas oculomotor function during restricted viewing suggested saccade dysmetria in ASD by altered pontocerebellar motor modulation. METHODS Oculomotor function was recorded using remote eye tracking in 142 ASD participants and 142 matched neurotypical controls during free viewing of naturalistic videos with and without human content. The sample was heterogenous concerning age (6-30 years), cognitive ability (60-140 IQ), and male/female ratio (3:1). Oculomotor function was defined as saccade, fixation, and pupil-dilation features that were compared between groups in linear mixed models. Oculomotor function was investigated as ASD classifier and features were correlated with clinical measures. RESULTS We observed decreased saccade duration (∆M = -0.50, CI [-0.21, -0.78]) and amplitude (∆M = -0.42, CI [-0.12, -0.72]), which was independent of human video content. We observed null findings concerning fixation and pupil-dilation features (POWER = .81). Oculomotor function is a valid ASD classifier comparable to social attention concerning discriminative power. Within ASD, saccade features correlated with measures of restricted and repetitive behavior. CONCLUSIONS We conclude saccade dysmetria as ASD oculomotor phenotype relevant to visual exploration. Decreased saccade amplitude and duration indicate spatially clustered fixations that attenuate visual exploration and emphasize endogenous over exogenous attention. We propose altered pontocerebellar motor modulation as underlying mechanism that contributes to atypical (oculo-)motor coordination and attention function in ASD.
Can carbon credits fund riparian forest restoration?

Ecological restoration is increasingly called on to provide ecosystem services (ES) valuable to humans, as well as to benefit biodiversity and improve wildlife habitat. Where mechanisms to pay for ES exist, they may serve as incentives to embark on habitat restoration projects. We evaluated the potential of newly established carbon markets in the United States to incentivize afforestation along riparian corridors, by comparing the income earnable by carbon offset credits with the costs of planting, maintaining, and registering such a restoration project in California. We used a 20‐year chronosequence of riparian forest sites along the Sacramento River as our model project. We found that carbon credits can repay more than 100% of costs after two decades of regrowth, if sufficient effort is put into sampling intensity in the first post‐restoration decade. However, carbon credits alone are unlikely to entice landowners currently engaged in agricultural activities to switch from farming crops to farming habitat.
Environmental DNA surveys detect distinct metazoan communities across abyssal plains and seamounts in the western Clarion Clipperton Zone

The deep seafloor serves as a reservoir of biodiversity in the global ocean, with >80% of invertebrates at abyssal depths still undescribed. These diverse and remote deep‐sea communities are critically under‐sampled and increasingly threatened by anthropogenic impacts, including future polymetallic nodule mining. Using a multigene environmental DNA (eDNA) metabarcoding approach, we characterized metazoan communities sampled from sediments, polymetallic nodules and seawater in the western Clarion Clipperton Zone (CCZ) to test the hypotheses that deep seamounts (a) are species richness hotspots in the abyss, (b) have structurally distinct communities in comparison to other deep‐sea habitats, and (c) that seafloor particulate organic carbon (POC) flux and polymetallic nodule density are positively correlated with metazoan diversity. eDNA metabarcoding was effective at characterizing distinct biotas known to occur in association with different abyssal substrate types (e.g., nodule‐ and sediment‐specific fauna), with distinct community composition and few taxa shared across substrates. Seamount faunas had higher overall taxonomic richness, and different community composition and biogeography than adjacent abyssal plains, with seamount communities displaying less connectivity between regions than comparable assemblages on the abyssal plains. Across an estimated gradient of low to moderate POC flux, we find lowest taxon richness at the lowest POC flux, as well as an effect of nodule size on community composition. Our results suggest that while abyssal seamounts are important reservoirs of metazoan diversity in the CCZ, given limited taxonomic overlap between seamount and plains fauna, conservation of seamount assemblages will be insufficient to protect biodiversity and ecosystem function in regions targeted for mining.
Outcomes of Airway Stents in the Palliative Care of Patients With Cancer

Introduction: A significant proportion of patients with advanced primary or metastatic intrathoracic malignancy will eventually develop central airway obstruction. The morbidity associated with malignant airway obstruction (MAO) is considerable and the management is difficult. Our aim was to evaluate the outcomes of tracheobronchial stenting in patients with MAO and its role in palliative care. Material and Methods: This retrospective study involved a consecutive case series of patients with advanced cancer with MAO who underwent tracheobronchial stenting between August 2014 and August 2019. The European Cooperative Oncology Group (ECOG) scale was used to evaluate patient functional status before and after tracheobronchial stenting. Univariate survival analysis included Kaplan-Meier curves with Log-Rank test, while Cox regression was used as a multivariate analysis. Results: We included 28 patients with median age of 55.0 years (interquartile range = 49.3-66.5) and 89.3% male. The most frequent primary tumour was the esophagus followed by lungs. The majority of the patients (75%) expressed immediate symptom relief after stenting and there was a significant improvement in the mean ECOG performance status (PS; P = .005). There was no intraprocedure mortality and complications were observed in 6 patients. The median survival after airway stenting was 39.0 days (95% CI = 32.2-45.8) with poorer PS after stent insertion associated with lower overall survival (hazard ratio = 2.3 [95% CI = 1.1-4.9], P = .030) on multivariate analysis. Conclusion: Airway stent is a safe and effective procedure that offers rapid palliation of symptoms with no major complications. Therefore, stent placement should be considered as part of the treatment of patients with terminal cancer.
Body Mass Index, Physical Activity Habits and Physical Function Contribute to Fatigue in the Rest Home Residents

ABSTRACT Backgrounds Fatigue is a common complaint in older adults living in rest homes. The aim of this study was to investigate the factors associated with fatigue among older adults living in a rest home. Methods This cross-sectional study was carried out with a total of 92 older adults. Fatigue was evaluated by the Fatigue Severity Scale (FSS). The sociodemographic characteristics, quadriceps and handgrip strength, functional capacity and physical function were assessed using a structured questionnaire, digital dynamometers, 6-minute walking test and Short Physical Performance Battery, respectively. Results The prevalence of fatigue was 67.4%. FSS showed significant correlations with age, female gender, body mass index, physical activity habits, quadriceps strength, handgrip strength, functional exercise capacity, and physical function. However, in the regression analysis, only body mass index, physical activity habits and physical function were responsible for 51% of the variance in fatigue among rest home residents. Physical activity habits and physical function were the best predictors of fatigue explaining 47.5% of variance. Conclusion This study demonstrated that body mass index, physical activity habits and physical function contributed to fatigue in rest home residents. These factors can be used to identify individuals at high risk of fatigue and to attenuate fatigue levels.
Effects of Exercise in Patients With Amyotrophic Lateral Sclerosis

Supplemental digital content is available in the text. Objective The aim of this study was to systematically review the efficacy and safety of exercise in patients with amyotrophic lateral sclerosis (ALS). Design Randomized controlled trials of exercises for ALS were searched in PubMed, EMBASE, Web of Science, Cochrane Library, China Biology Medicine database, China National Knowledge Internet, VIP database, and Wanfang database. The primary outcomes were functional ability, pulmonary function, and quality of life. The secondary outcomes were muscle strength, fatigue and adverse events. Meta-analysis was performed using the RevMan Version 5.3 software. Results Seven randomized controlled trials including 322 patients with ALS met the inclusion criteria. Meta-analysis showed that the functional scores at long-term (standardized means difference, 0.47; 95% confidence interval, 0.08–0.86; P = 0.02) and forced vital capacity percentage predicted (mean difference, 1.71; 95% confidence interval, 0.10–3.31; P = 0.04) of patients with ALS in the exercise group were significantly higher than those in the group of no exercise or usual care. No significant difference was observed in muscle strength and quality of life. Endurance or aerobic exercise improved the functional scores of patients with ALS (standardized means difference, 0.36; 95% confidence interval, 0.04–0.68; P = 0.03). Exercise did not aggravate fatigue or result in adverse event. Conclusion Exercise can significantly improve the functional ability and pulmonary function of patients with ALS safely.