Miracle-dz/UniFAR-FTUs huggingface dataset:
Exposure of mice to MDPV during adolescence increases the psychostimulant, rewarding and reinforcing effects of cocaine in adulthood

Complete List of Authors: López-Arnau, Raúl; Universitat de Barcelona, Department of Pharmacology and Therapeutic Chemistry, Pharmacology Section and Institute of Biomedicine (IBUB), Faculty of Pharmacy Luján, Miguel-Angel; University Pompeu Fabra, Department of Heath and Life Sciences Duart-Castells, Leticia; Universitat de Barcelona, Department of Pharmacology and Therapeutic Chemistry, Pharmacology Section and Institute of Biomedicine (IBUB), Faculty of Pharmacy Pubill, David; Universitat de Barcelona, Unitat de Farmacologia i Farmacognòsia, Facultat de Farmàcia Camarasa, Jorge; University of Barcelona, Pharmacology and Therapeutic Chemistry Valverde, Olga; University Pompeu Fabra, Department of Heath and Life Sciences Escubedo, Elena; Universitat de Barcelona, Unitat de Farmacologica i Farmacognosia
Promote T Cell Activation Ezrin and Moesin Function Together to

The highly homologous proteins ezrin, radixin, and moesin link proteins to the actin cytoskeleton. The two family members expressed in T cells, ezrin and moesin, are implicated in promoting T cell activation and polarity. To elucidate the contributions of ezrin and moesin, we conducted a systematic analysis of their function during T cell activation. In response to TCR engagement, ezrin and moesin were phosphorylated in parallel at the regulatory threonine, and both proteins ultimately localized to the distal pole complex (DPC). However, ezrin exhibited unique behaviors, including tyrosine phosphorylation and transient localization to the immunological synapse before movement to the DPC. To ask whether these differences reﬂect unique requirements for ezrin vs moesin in T cell signaling, we generated mice with conditional deletion of ezrin in mature T cells. Ezrin (cid:1) / (cid:1) T cells exhibited normal immunological synapse organization based upon localization of protein kinase C- (cid:2) , talin, and phospho-ZAP70. DPC localization of CD43 and RhoGDP dissociation inhibitor, as well as the novel DPC protein Src homology region 2 domain-containing phosphatase-1, was also unaffected. However, recruitment of three novel DPC proteins, ezrin binding protein of 50 kDa, Csk binding protein, and the p85 subunit of PI3K was partially perturbed. Biochemical analysis of ezrin (cid:1) / (cid:1) T cells or T cells suppressed for moesin using small interfering RNA showed intact early TCR signaling, but diminished levels of IL-2. The defects in IL-2 production were more pronounced in T cells deﬁcient for both ezrin and moesin. These cells also exhibited diminished phospholipase
Journal of University Teaching & Learning Practice Journal of University Teaching & Learning Practice Developing a peer supported feedback model that enhances oral Developing a peer supported feedback model that enhances oral proficiency in French proficiency in French

Abstract This article investigates the process of development for a novel online peer-supported approach that enhances oral proficiency in French at an Australian university to cope with ever more complex challenges. These challenges include students with mixed ability in the same class, reduced teaching resources and student surveys identifying a lack of speaking practice affecting confidence and performance in oral assessments. A related aim of the present study was to facilitate assessment literacy of our students by encouraging them to make links between the skills practised in class and the requirements for the final oral summative assessment. Methodology draws on educational practice influenced by a social constructivist approach to develop a learning model using online peer feedback, where more advanced learners support less experienced peers outside the formal classroom. Preliminary results reveal that although the model was deemed to be ‘generally effective’ in enhancing speaking skills and developing a better understanding of assessment literacy, it needs to enable learners to build their meta-skills across the three-year degree program to be truly effective. The conclusion explores further development and expansion of the learning approach across the French undergraduate program and makes future recommendations. Abstract Abstract This article investigates the process of development for a novel online peer-supported approach that enhances oral proficiency in French at an Australian university to cope with ever more complex challenges. These challenges include students with mixed ability in the same class, reduced teaching resources and student surveys identifying a lack of speaking practice affecting confidence and performance in oral assessments. A related aim of the present study was to facilitate assessment literacy of our students by encouraging them to make links between the skills practised in class and the requirements for the final oral summative assessment. Methodology draws on educational practice influenced by a social constructivist approach to develop a learning model using online peer feedback, where more advanced learners support less experienced peers outside the formal classroom. Preliminary results reveal that although the model was deemed to be ‘generally effective’ in enhancing speaking skills and developing a better understanding of assessment literacy, it needs to enable learners to build their meta-skills across the three-year degree program to be truly effective. The conclusion explores further development and expansion of the learning approach across the French undergraduate program and makes future recommendations.
Asking for Too Much? Evidence from the NYC Taxi Cab Industry

This paper explores how setting default options above the social norm influences consumer behavior in a setting where consumers can use a suggested default or manually enter a tip amount. To identify the impact increasing the suggested tip levels have on behavior, I take advantage of the variation of credit payment vendors within the New York City taxi industry. Using both timing of the payment screen installations and variation across taxis in the technology vendor, I identify how a five percentage point increase in the default tip percentages influence consumer tipping behavior. I find that higher tip suggestions result in an increase in tip amounts of approximately $0.57 per fare which translates to an increase in a cab drivers hourly wage by 5.35 percent. I discuss the policy implications of these results and how they are particularly relevant for low-wage workers in economies increasingly dominated by the service industry.
An Analysis of Code-Mixing and Code-Switching Used by Indonesia Lawyers Club on TV One

: This research aims to find out kinds of code-mixing and code-switching, the dominant kinds of code-mixing and code-switching and the factors code-mixing and code-switching used by Indonesia Lawyers Club on TV One. To analyze the data, the researchers used theory sosiolinguistics by Sumarsono’s (2011:11). The date of the research was episode, Corona: Simalakama Bangsa Kita, Aired on 24th march 2020, with the durations of video 72 minutes. Code-mixing and code-switching occur in a communication process, it happens in the one of the phenomenon and become trend style language in program TV Indonesia. Therefore, this research focuses on code-mixing and code-switching kinds that emerges on Talk Show Program Indonesia Lawyers Club on TV One. The objective of this research was to find out the kinds of code-mixing and code-switching that appear on Talk Sow Program Indonesia Lawyers Club on TV One channel. This research was descriptive qualitative method and the human research is the main instrument of this research. In collecting the data, this research utilized documentation method. This study employed content analysis which focused on analyzing the kinds of code-mixing and code-switching which defined by Suwito. Then, the result of kinds of code-mixing and code-switching were counted by using Ardhana’s formula. The result after analyzing the video, there were 42 data in the kinds of code-mixing and code-switching. In the kinds of code-mixing and code-switching, the mostly kinds used was Outer of code-mixing 31/42 data and the lowest kinds used was Inner of code-mixing 2/42 data.
Descriptive Study on Effects of Organizational Communication towards Organizational Citizenship Behaviour

Food tourism has become a familiar sector where several restaurants and food stores are focusing on maximizing the benefits of cuisine which benefits the individual producer or businessman in Punjab. Although food tourism has emerged lately and has become highly popular, there are certain hitches related to that of food tourism when it comes to Punjab. The present study is an attempt at discovering the problems and challenges associated with food tourism and to establish the perception of tourists regarding food as tourist attraction in Punjab. The present study is based on the collection of data through a self-structured questionnaire. The idea behind the research is to analyse the potential of food tourism in the states of Punjab. The study is intended to take place by the distribution of self-structured questionnaires in selected respondents in the states Amritsar, Jalandhar and Patiala and generalise the results to Punjab. The outcome of the questionnaire suggests that there is a positive correlation between food and tourism in Punjab. there is a significant relationship between food and tourist’s decision to visit Punjab and a positive relation between tourist’s perception and potential of food tourism in Punjab. In this examination the connection between authoritative duty and organization citizenship conduct is inspected. To this end, connection and mean and standart values have been done to uncover the impacts of organization correspondence on organization citizenship conduct. In this investigation, among the hierarchical correspondence measurements, just the component of correspondence with administrators is altogether related with alturism and city righteousness measurements of organization citizenship conduct.
Distinguishing Chinese Guqin and Western Baroque pieces based on statistical model analysis of melodies

This paper proposes a method to determine different genres of melody according to the melodic interval of the melody with Western Baroque and Chinese Guqin music used as an example. Melodic interval histogram and Markov chains are proposed to differentiate Western Baroque and Chinese Guqin music, where the similarity is measured with Kullback-Leibler divergence. A significance test is done and the results show that our method is capable of distinguishing between Western Baroque and Chinese Guqin pieces. This conclusion further supports that extracting melodic interval features could be a possible way to distinguish symbolic music melodies from different genres.
PRODUCTION OF PEDOT-COATED SCAFFOLDS BY VAPOR PHASE POLYMERIZATION FOR NEURAL REGENERATION

XI RESUMO . XIII INDEX . XV LIST OF FIGURES. XVII LIST OF TABLES. XIX ACRONYMS . XXI 1. MOTIVATION AND OBJECTIVES. 1 2. INTRODUCTION . 3 2.3. 1. PEDOT . 7 3. MATERIALS AND METHODS . 9 4. RESULTS AND DISCUSSION . 11 4.1. 1. Polymer Solutions and Electrospinning. 11 4.1. 2. Vapor Phase Polymerization . 16 4.2. 1. SEM . 20 4.2. 2. FTIR . 24 4.2.3. Electrical characterization . 26 4.3. 1. Citotoxicity. 27 4.3. 2. SH-SY5Y Differentiation . 29 4.3. 3. SH-SY5Y Growth on Materials . 30 5. CONCLUSIONS AND FUTURE PERSPECTIVES . 33 6. REFERENCES . 35 7. APPENDIX . 41
Studies on genetic variability parameters and character association in fennel ( Foeniculum vulgare Mill.) under semiarid conditions of Rajasthan

Seventy-eight genotypes of fennel ( Foeniculum vulgare Mill.) were evaluated in a randomized block design with three replications at the research farm, S.K. N. College of Agriculture, Jobner (Rajasthan) for seed yield and quality parameters. The analysis of variance revealed significant differences between the entries for all the characters studied indicating the existence of variability among genotypes. The phenotypic coefficient of variation (PCV) was slightly higher than corresponding genotypic coefficient of variation (GCV) for most of the characters except total Soluble sugar content which indicates that environment has little influence on the character’s expression. The present study showed higher heritability values (>70% for most of the characters) ranging from 10.0 to 91.6%. High heritability coupled with high genetic gain and coefficient of variability was observed for umbels per plant, seeds per umbel, harvest index, crude fibre content and seed yield per plant, indicating a possible role of additive gene effect for the genotypic variance for these characters. Phenotypic and genotypic correlation coefficient indicated that seed yield per plant showed significant and positive genotypic association with total plant height, branches per plant, umbels per plant, 1000-seed weight, biological yield per plant and harvest index. Hence, the selection based on phenotypic performance for these characters would be beneficial for achieving the desired gain.
Local and Global Ductility of Wide-Beam RC Frames

Italian and Spanish seismic codes prescribe lower behaviour factor (q) for wide-beam reinforced concrete moment resisting frames (WBF) with respect to conventional q factors adopted for deep-beam frames (DBF). Conversely, other relevant seismic codes worldwide, such as Eurocode 8, consider WBF capable of high ductility performances, provided that design rules related to (i) stress transfer in connections, (ii) lateral stiffness and (iii) energy dissipation are complied. On the other hand, local ductility of wide beams (WB) appears to be systematically lower than that for deep beams (DB). A parametric comparative numerical analysis of deformations of DB and WB, following the current approach, shows that WB have larger ultimate chord rotation but lower ductility in terms of chord rotation than DB despite the similar ductility in curvature, which is mainly due to a lower plastic hinge lengths in WB. Aimed at verifying whether such disadvantage is overcome by modern codes or not, several archetype European RC residential buildings are designed alternatively with DB or WB. Seismic performances are assessed with different degree of detail. Results suggest that WBF provide at least similar global seismic capacities than DBF, especially in frames whose design is ruled by damage limitation limit state. Hence, any reduction of q in Mediterranean codes for WBF appears to be at least obsolete.
PERFORMANCE OF A SINGLE CHAMBER SOIL MICROBIAL FUEL CELL ACROSS VARIED EXTERNAL LOADS FOR POWER GENERATION.

The soil is beginning to receive attention as suitable inoculums for Microbial Fuel Cells (MFCs) designed for remediation and for electricity generation because of its high microbial load. However, not much has been done in this aspect beyond laboratory based experiment. This study is aimed at generating electricity from agricultural soil, utilizing the microorganisms already present and the soil nutrients as the sole substrates and to investigate the performance of the soil Microbial Fuel Cell (MFC) across varied external loads. The study used the mud watt MFC kit inoculated with mud prepared from topsoil, collected from a garden where crops have been cultivated over the years. The electrodes (anode and cathode, 7cm diameter each), made of carbon felt material with conducting wires made of graphite, were housed in the same chamber and placed 4 cm apart. Voltage drop across seven external resistances 4670 Ω, 2190 Ω, 1000 Ω, 470 Ω, 220 Ω, 100 Ω and 47 Ω, were measured every 24 hours, with a digital multi-meter, for 40 days. The maximum open circuit voltage from this study was 731 mV, whereas the maximum power density was 65.40 mW/m 2 at a current density of 190.1 mAm -2 . The optimum performance of the MFC was achieved with the 470 Ω which is an indication that the internal resistance of the soil MFC of this present study is close to 470 Ω. This study revealed that MFCs constructed from agricultural topsoil are capable of producing electrical power continuously, across different external loads, without addition of any substrate.
Monetary policy rules with ﬁnancial instability

The Working Paper Series of the Czech National Bank (CNB) is intended to disseminate the results of the CNB’s research projects as well as the other research activities of both the staff of the CNB and collaborating outside contributor, including invited speakers. The Series aims to present original research contributions relevant to central banks. It is refereed internationally. The referee process is managed by the CNB Research Department. The working papers are circulated to stimulate discussion. The views expressed are those of the authors and do not necessarily reflect the official views of the CNB. Abstract To provide a rigorous analysis of monetary policy in the face of financial instability, we extend the standard dynamic stochastic general equilibrium model to include a financial system. Our simulations suggest that if financial instability affects output and inflation with a lag, and if the central bank has privileged information about credit risk, monetary policy responding instantly to increased credit risk can trade off more output and inflation instability today for a faster return to the trend than a policy that follows the simple Taylor rule. This augmented rule leads in some parameterizations to improved outcomes in terms of long-term welfare, however, the welfare impacts of such a rule appear to be negligible.
Cross-border Social Commerce: from a Trust Transfer Perspective

Social commerce has been seeing exponential growth due to the COVID-19 pandemic, which brought a wave of cross-border commerce as consumers purchase more items online. Business uses social media to reach new markets by accessing potential global buyers, expanding their target markets, and increasing brand popularity. Cross-border ecommerce studies showed that perceived risk is a critical factor that reduces individuals’ willingness to purchase unfamiliar foreign products. We introduced an emerging business model, cross-border social commerce (CBSC) and examined the mitigation of perceived risk through trust transfer in a CBSC context. To capture consumers’ purchase intention of cross-border commerce, we conducted an online scenario-based survey. Survey respondents comprising a total of 321 social media users in Indonesia were observed. The results demonstrate that consumers’ trust can be transferred from friends and platforms to brands, and the transfer effect is contingent on the popularity of the brand. Our findings have crucial implications for trust transfer and cross-border social commerce. This study contributes to academia by introducing a new business model and advancing our understanding of how to enhance trust and mitigate risk. Practitioners can gain insight into trust building in CBSC context. © 2022. Journal of Electronic Commerce Research. All Rights Reserved.
Emergency retrofitting of shear-damaged RC columns using fiber-belt prestressing

: This study proposes a rehabilitation method (emergency retrofitting) to restore the axial compression capacity and shear resistance mechanism of shear-damaged reinforced concrete (RC) columns. For the emergency retrofitting of shear-damaged RC columns, lashing belts comprising a ratchet buckle and aramid fiber belts are used. Initial prestressing of the damaged RC columns is supplied by using lashing belts; therefore, this technique offers both active and passive confinement as well as shear strengthening. The key concept of this approach is to provide active confinement to firmly confine the damaged RC column, thereby uniting these blocks as a confined concrete unit with its vertical and lateral load-carrying capacities restored. To determine the rehabilitation capacity achieved using fiber-belt prestressing, axial compression and cyclic loading tests were conducted. RC columns externally. The active confinement is used to close cracks in damaged RC columns and to recover their vertical and lateral load-carrying capacities and ductility. To investigate the rehabilitation capacity using fiber-belt prestressing, the damage level of the RC columns, the use of epoxy resin repair, and lateral retrofitting with high-strength materials are considered in axial compression and cyclic loading tests, and their results are discussed.
Edinburgh Research Explorer The Doors and People Test

Objective: Memory deficits in patients with frontal lobe lesions are most apparent on free recall tasks that require the selection, initiation, and implementation of retrieval strategies. The effect of frontal lesions on recognition memory performance is less clear with some studies reporting recognition memory impairments but others not. The majority of these studies do not directly compare recall and recognition within the same group of frontal patients, assessing only recall or recognition memory performance. Other studies that do compare recall and recognition in the same frontal group do not consider recall or recognition tests that are comparable for difficulty. Recognition memory impairments may not be reported because recognition memory tasks are less demanding. Method: This study aimed to investigate recall and recognition impairments in the same group of 47 frontal patients and 78 healthy controls. The Doors and People Test was administered as a neuropsychological test of memory as it assesses both verbal and visual recall and recognition using subtests that are matched for difficulty. Results: Significant verbal and visual recall and recognition impairments were found in the frontal patients. Conclusion: These results demonstrate that when frontal patients are assessed on recall and recognition memory tests of comparable difficulty, memory impairments are found on both types of episodic memory test.
Effects of Seed Storage Time on Germination of Ancylobothrys Petersiana Seed

The propagation of wild plants is lagging even though rural communities are eager to be involved in the propagation and domestication of valued wild fruit trees. Erratic rainfall, dry spells are common in the areas where the fruit tree exist and together with the soil compaction making it difficult for seed to be buried in the soil to enable germination but remain on the surface. The objective was to evaluate the effects of the length of seed storage with natural dehydration on loss of seed viability and germination. The seeds were obtained and prepared from mature ripen fruits. The seeds were tested for viability prior to the experiment. The experiment was laid out in a complete randomized design (CRD) with eight treatments replicated four times. The seeds were sown at different storage periods from the first day of harvesting the fruits and seed preparation and then sown at fourteen days interval up to ninty eight days from seed preparation. The soil media was obtained from the fruit tree the original site where they occur naturally. The data collected include germination percentage and development into individual seedlings or plants that could be transplanted. The data was analysed for Analysis of Variance (ANOVA) using Genstat version 14. The least significant different was used to identify different means. Prolonging seed storage with dehydration had significant effect on seed viability and seed germination. The results show that there was significant difference (p<0.001) between treatments used. Prolonged seed storage owing to seed dehydration has significant effects (P < 0.05) on seed viability and germination. The study has shown that climbing wild apricot seed viability is lost due to longevity of seed storage with loss of moisture. Extreme seed dehydration of A. petersiana resulted in seed splitting and separation of cotyledons and this worsened the chances of reviving of the seed during hydration.