Miracle-dz/UniFAR-FTUs huggingface dataset:
Pitch and Duration Mismatch Negativity and Heschl’s Gyrus Volume in First-Episode Schizophrenia-Spectrum Individuals

Background. The mismatch negativity (MMN) brainwave indexes novelty detection. MMN to infrequent pitch (pMMN) and duration (dMMN) deviants is reduced in long-term schizophrenia. Although not reduced at first psychosis, pMMN is inversely associated with left hemisphere Heschl’s gyrus (HG) gray matter volume within 1 year of first hospitalization for schizophrenia-spectrum psychosis, consistent with pathology of left primary auditory cortex early in disease course. We examined whether the relationship was present earlier, at first psychiatric contact for psychosis, and whether the same structural-functional association was apparent for dMMN. Method. Twenty-seven first-episode schizophrenia-spectrum (FESz) and 27 matched healthy comparison (HC) individuals were compared. EEG-derived pMMN and dMMN were measured by subtracting the standard tone waveform (80%) from the pitch- and duration-deviant waveforms (10% each). HG volumes were calculated from T1-weighted structural magnetic resonance imaging using Freesurfer. Results. In FESz, pMMN amplitudes at Fz were inversely associated with left HG (but not right) gray matter volumes, and dMMN amplitudes were associated significantly with left HG volumes and at trend-level with right HG. There were no structural-functional associations in HC. Conclusions. pMMN and dMMN index gray matter reduction in left hemisphere auditory cortex early in psychosis, with dMMN also marginally indexing right HG volumes. This suggest conjoint functional and structural pathology that affects the automatic detection of novelty with varying degrees of penetrance prior to psychosis. These brainwaves are sensitive biomarkers of pathology early in the psychotic disease course, and may serve as biomarkers of disease progression and as therapeutic outcome measures.
Inhibiting endoplasmic reticulum stress prevents the development of hypertensive nephrosclerosis

38 Introduction 39 Methods 42 Results 48 Discussion 54 Ph.D. Thesis – Rachel E. Carlisle McMaster University – Medical Sciences x References 61 Figures 66 CHAPTER 3 4-phenylbutyrate inhibits tunicamycin-induced acute kidney injury via CHOP/GADD153 repression 84 Chapter link 85 Author’s contributions 85 Abstract 87 Introduction 88 Methods 90 Results 97 Discussion 102 References 107 Figures 111 CHAPTER 4 Endoplasmic reticulum stress inhibition reduces hypertension through the preservation of resistance blood vessel structure and function 127 Chapter link 128 Author’s contributions 128 Abstract 13
Hepatitis A in Poland in 2017 - epidemic increase cases

AIM The aim of this article is to describe and assess changes in epidemiological situation of Hepatitis A in Poland in 2017. MATERIALS AND METHODS The assessment was based on the information from the individual case questionnaires, aggregated data from the bulletins “Infectious diseases and poisonings in Poland in 2017” and reports from epidemiological investigations in outbreaks of hepatitis A, submitted by the sanitary-epidemiological stations to the Department of Epidemiology of Infectious Diseases and Surveillance in NIPH-NIH. RESULTS In 2017 a large increase of HAV cases and hepatitis A incidence was observed in Poland (3006 cases, incidence 7.8 per 100 000) in comparison to 2016 (35; 0.09). Majority of the cases were registered in large cities, where incidence was 3 times higher than in rural areas. Among reported there were 501 cases (16.6% of all cases) selfdeclaring as man who have sex with man (MSM). In course of the year an increasing trend in the number of cases was observed until September and the increase of male to female ratio (m/f) until May. Moreover 251 HAV outbreaks were reported, number of which increased until October and with the increase of m/f ratio in these outbreaks until April. From July to October there was an increase in the number of small outbreaks with m/f ratio equal 1. There were 178 imported cases reported, most of them from European countries- especially Germany and Spain. SUMMARY AND CONCLUSIONS In 2017 over 80-fold increase of HAV cases and hepatitis A incidence was observed in comparison to previous years. Available epidemiological data indicate that ongoing HAV outbreak among MSM in Europe reached also Poland, and data from the second part of the year suggest infection spreading in non-MSM part of the population. It is therefore highly indicated that the list of risk groups for which vaccination against hepatitis A is recommended should also be expanded for MSM. To avoid such increase in the number of cases in future it is recommended to introduce vaccinations in risk groups as soon as large international outbreak occurs.
Synthesis of Poly(2-aminothiazole)-Coated Polystyrene Particles and Their Excellent Hg(II) Adsorption Properties

Synthesis of conjugated polymer-coated latex particles is an effective method to improve the poor processability of conjugated polyheterocycles. The key to success is to control the overlayer thickness so it is less than the size of the solvated layer of polymeric stabilizer. This paper presents a protocol to coat polymer latex particles with poly(2-aminothiazole) (PAT), which is a relatively new heterocyclic conjugated polymer. The protocol is based on chemical oxidative polymerizations of 2-aminothiazole using copper chloride as the oxidant at a fixed oxidant/monomer molar ratio of 0.5 in aqueous media in the presence of poly(N-vinyl-2-pyrrolidone)-functionalized polystyrene (PS) latex. The effects of monomer concentration, PS concentration, and polymerization temperature on the morphology of the PAT-coated PS composite particles were investigated by SEM and TEM, and the resulting composite particles characterized by FTIR and XPS. Optimization of the initial monomer concentration allowed colloidally stable PAT-coated PS composite particles to be formed at ambient temperature, and the PAT loading was easily adjusted by varying the initial PS concentration. The Hg(II) adsorption properties of selected PAT-coated PS composite particles were assessed preliminarily. The maximum adsorption capacity at 25 °C reached 440.25 mg/g, which is much higher than many other adsorbents.
ABO and Rh Blood Groups and Risk of Myelomeningocele.

AIM The etiology of myelomeningocele is multifactorial. Genetic alterations in folate-dependent single carbon metabolism may to cause neural tube defects. ABO and Rhesus (Rh) blood groups, that share similar genetic localisations as folate mechanism, have relations with various metabolic and malignant diseases. The aim of this study was to investigate the relationship between the distribution of ABO or Rh blood group antigens and the incidence of myelomeningocele. MATERIAL AND METHODS A retrospective data was reviewed of all myelomeningocele patients operated at our hospital between years 2014 and 2019. Age, sex, delivery method, physical and neurological examination findings, and radiological findings alongside with blood type of each patient were recorded. The data of blood group distribution among the study patients was compared to the data of healthy individuals in the same region. RESULTS Patients with group B and AB showed a higher chance of developing myelomeningocele. Rh-positive blood group was associated with high incidence of myelomeningocele (93.5%), whereas Rh-negative blood group showed least association (6.5%). Rh-positive blood group was also more frequent in patients with myelomeningocele with hydrocephalus and Chiari malformation. CONCLUSION ABO and Rh blood groups have an effect on the development of myelomeningocele under the influence of environmental or genetic factors.
Self-criticism, self-compassion, and perceived health: moderating effect of ethnicity

Abstract A caring and compassionate attitude toward the self (i.e., self-compassion) has been linked to various mental and physical health benefits. The Self-Compassion Scale (SCS) is widely used in psychology literature in order to assess global self-compassion. However, recent evidence suggests that the single factor model comprising positive and negative items of the SCS in fact measures two distinct constructs (i.e., self-criticism/self-coldness and self-compassion) with different psychological correlates. Given these recent findings, in addition to other research that highlights cultural differences in self-conceptualizations and self-evaluations, the present study examined potential ethnic differences in the relationships between self-criticism, self-compassion, and perceived health. Participants included 728 college students (141 Asian American, 449 European American, and 138 Hispanic/Latinx individuals) attending a university in the northeast United States. Results indicated that the relationship between self-criticism and self-compassion was significantly different across ethnicity. In addition, the relationships between these two constructs (i.e., self-criticism and self-compassion) and perceived health were moderated by ethnicity. Our findings suggest that focusing on global self-compassion scores (i.e., total SCS scores) may miss some of the important cultural or ethnic differences in the relationships between self-criticism, self-compassion, and perceived health.
On the conundrum of cognitive impairment due to depressive disorder in older patients

Objectives Depressive symptoms and cognitive impairment often concur in older persons. Differentiating the cause of cognitive impairment in older persons with Depressive Disorder (DD) from other diseases such as Alzheimer’s Disease (AD) is challenging. The goal of this study was to characterize cognitive impairment in older persons with DD. Design Cross-sectional retrospective observational clinical cohort study using patient records from 2014 to 2018. Setting Gerontopsychiatric services of Ulm University at Bezirkskrankenhaus Günzburg serving as primary psychiatric care institution and tertiary referral center for psychiatric care for older persons. Partcipants DD was diagnosed according to ICD-10 criteria. When indicated by the medical history or neuropsychological assessment further diagnostic procedures were initiated. Cerebrospinal fluid (CSF) tap was routinely the first additional procedure. If patients did not consent to CSF tap or contraindications were present, 18F-fluordesoxyglucose-PET (FDG-PET) or Amyloid-PET (Am-PET) were performed. Materials and methods Extensive neuropsychological test battery to assess cognitive profile. Results 457 subjects were diagnosed with DD (DD-all; age 50–94; 159 males, 298 females). Biomarkers were assessed in 176 persons; in 90 of these subjects AD-biomarkers were negative (DD-BM-; age 54–89; 40 males, 50 females), and in 86 subjects at least one biomarker was compatible with AD (DD-BM+; age 60–90; 31 males, 55 females). Cognitive performance was below healthy controls (HC; n = 56; age 50–80; 30 males, 26 females) for all groups of patients with DD. With case-control matching of HC and DD-BM- we find that executive functions are impaired in about one out of three and delayed recall in about two out of three patients with DD. Conclusion Cognitive impairment is frequent in older persons with DD. Cognitive profile in older patients with DD without and with biomarkers of AD is not distinguishable. Therefore, cognitive impairment due to DD should be diagnosed after exclusion of comorbid AD.
Effect of Two Strength Training Models on Muscle Power and Strength in Elite Women’s Football Players

This study evaluates changes in power and strength after implementing two different models of 9-week strength training in elite women’s football players. A group of 13 players (age 20.2 ± 3.3 years, body mass 57.2 ± 3.7 kg, height 163.6 ± 5.3 cm, VO2max 45.2 ± ml/min) underwent either a complex (the intermittent load type) or combined (the maximal strength and dynamic method) model of training. The training load was tailored to each athlete. Results showed that the complex model of training improved power (10 W/kg, p = 0.006) and height of vertical jump (5.3 cm, p = 0.001), weight of 1 Repeat Maximum (1RM) which was (5.8 kg, p = 0.015), power and speed in the acceleration phase of barbell half squats (BHS) at weights from 20 to 60 kg, and the number of repetitions in BHS (10.3%, p = 0.012). The combined model of training improved the time of shuttle run (0.44 s, p = 0.000), weight of 1RM in BHS (9.6kg, p = 0.000) and BP (4 kg, p = 0.000), power in the acceleration phase of BHS at weights from 50 to 60 kg, the number of repetitions in BP (14.3%, p = 0.000), BHS (9.4%, p = 0.002), barbell bench pulls (11.9%, p = 0.002) and sit-ups (7.7%, p = 0.001). These findings indicate that the complex model of training improves explosive abilities, whereas the combined model is effective for developing strength at weights close to players’ 1RM and for repeatedly overcoming resistance. Therefore, coaches should choose the training model based on the needs of individual players.
1497PEfficacy and safety of patients treated long-term with trabectedin (t) on the expanded access program: A retrospective analysis

E. Davis, S. Schuetze, S. Patel, R. Maki, R.L. Jones, C.R. Shin, R. Knoblauch, G. Wang, M. Smith, G.D. S. Demetri, P. Merriam Division of Hematology/Oncology, Vanderbilt University Medical Center, Nashville, TN, USA, Division of Hematology/Oncology, University of Michigan, Ann Arbor, MI, USA, Department of Sarcoma Medical Oncology, The University of Texas, MD Anderson Cancer Center, Houston, TX, USA, Medical Oncology and Hematology, Monter Cancer Center, Lake Success, NY, USA, Medical Oncology, Royal Marsden Hospital, London, UK, Med Group Oncology, Janssen Scientific Affairs, LLC, Horsham, PA, USA, Clin Oncology, Janssen Pharmaceuticals, Raritan, NJ, USA, Biostats, Janssen Research & Development, LLC, Spring House, PA, USA, Center for Sarcoma and Bone Oncology, Dana-Farber Cancer Institute and Ludwig Center at Harvard, Boston, MA, USA, Center for Sarcoma and Bone Oncology, Dana-Farber Cancer Institute, Boston, MA, USA
Chinese Sub-culture and Parental Involvement Strategies: An Anthropological Case Study of a Public School in Eastern America

Abstract The object of this paper is to reveal the role of subculture in Chinese immigrants in shaping parental involvement strategies at the school. The experimental design of this study relies on participant observation in a public school, located in large urban school district in Eastern America and 34 in-depth interviews to the parents and 8 educators there. The principal observation and conclusion shows the teachers in the school require academic support from the families and the Chinese immigrant families can meet these needs generally through practicing their a large family network and higher expectations for their children’s academic achievement. However for the administration perspective of parents’ involvement, it requires parents’ active involvement in community participation. The Chinese immigrant families tend to fail to satisfy this needs. The subculture of big family network of Chinese immigrants community is lack of tradition of community participation, which impedes them to be active community members within the American school.
Stereoselective Bupropion Hydroxylation by Cytochrome P450 CYP2B6 and Cytochrome P450 Oxidoreductase Genetic Variants

Bioactivation of the antidepressant and smoking cessation drug bupropion is catalyzed predominantly by CYP2B6. The metabolite hydroxybupropion derived from t-butylhydroxylation is considered to contribute to the antidepressant and smoking-cessation effects of the parent drug. Bupropion hydroxylation is the canonical in vitro and in vivo probe for CYP2B6 activity. P450 also requires obligate partnership with P450 oxidoreductase (POR). Human CYP2B6 and POR genes are highly polymorphic. Some CYP2B6 variants affect bupropion disposition. This investigation evaluated the influence of several human CYP2B6 and POR genetic variants on stereoselective bupropion metabolism, using an insect cell coexpression system containing CYP2B6, POR, and cytochrome b5. Based on intrinsic clearances (Clints), relative activities for S,S-hydroxybupropion formation were in the order CYP2B6.4 > CYP2B6.1 > CYP2B6.17 > CYP2B6.5 > CYP2B6.6 ≈ CYP2B6.26 ≈ CYP2B6.19 > CYP2B6.7 > CYP2B6.9 > > CYP2B6.16 and CYP2B6.18; relative activities for R,R-hydroxybupropion formation were in the order CYP2B6.17 > CYP2B6.4 > CYP2B6.1 > CYP2B6.5 ≈ CYP2B6.19 ≈ CYP2B6.26 > CYP2B6.6 > CYP2B6.7 ≈ CYP2B6.9 > > CYP2B6.16 and CYP2B6.18. Bupropion hydroxylation was not influenced by POR variants. CYP2B6-catalyzed bupropion hydroxylation is stereoselective. Though Vmax and Km varied widely among CYP2B6 variants, stereoselectivity was preserved, reflected by similar Clint(S,S-hydroxybupropion)/Clint(R,R-hydroxybupropion) ratios (1.8–2.9), except CYP2B6.17, which was less enantioselective. Established concordance between human bupropion hydroxylation in vitro and in vivo, together with these new results, suggests additional CYP2B6 variants may influence human bupropion disposition. SIGNIFICANCE STATEMENT Bupropion pharmacokinetics, metabolism, and clinical effects are affected by the CYP2B6*6 polymorphism. Other expressed CYP2B6 polymorphisms had diminished (*5, *6, *7, *9, *19, *26) or defective (*16, *18) in vitro bupropion hydroxylation. P450 oxidoreductase genetic variants had no effect on metabolism, suggesting no clinical consequence of this polymorphism. These CYP2B6 polymorphisms may portend diminished in vivo bupropion hydroxylation and predict additional clinically important variant alleles.
Incremental Health Care Burden of Treatment-Resistant Depression Among Commercial, Medicaid, and Medicare Payers.

OBJECTIVE This study compared health care use and costs among patients with treatment-resistant versus treatment-responsive depression across Medicaid, Medicare, and commercial payers. METHODS A retrospective cohort study was conducted by using Truven Health Analytics' commercial (2006-2017; N=111,544), Medicaid (2007-2017; N=24,036), and Medicare supplemental (2006-2017; N=8,889) claims databases. Participants were adults with major depressive disorder who had received one or more antidepressant treatments. Treatment resistance was defined as failure of two or more antidepressant treatments of adequate dose and duration. Annual use (hospitalizations and outpatient and emergency department [ED] visits) and costs were compared across patients by treatment-resistant status in each payer population. Incremental burden of treatment-resistant depression was estimated with regression analyses. Monthly changes in costs during 1-year follow-up were assessed to understand differential cost trends by treatment-resistant status. RESULTS In the three payer populations, patients with treatment-resistant depression incurred higher health care utilization than those with treatment-responsive depression (hospitalization, odds ratios [ORs]=1.32-1.76; ED visits, ORs=1.38-1.45; outpatient visits, incident rate ratio=1.29-1.54; p<0.001 for all). Compared with those with treatment-responsive depression, those with treatment resistance incurred higher annual costs (from $4,093 to $8,054 higher; p<0.001). Patients with treatment-resistant depression had higher costs at baseline compared with patients with treatment-responsive depression and incurred higher costs each month throughout follow-up. CONCLUSIONS Treatment-resistant depression imposes a significant health care burden on insurers. Treatment-resistant depression may exist and affect health care burden before a patient is identified as having treatment-resistant depression. Findings underscore the need for effective and timely treatment of treatment-resistant depression.
Mining TCGA database for tumor mutation burden and their clinical significance in bladder cancer

Abstract Background: Bladder cancer is the ninth most-common cancer worldwide and it is associated with high morbidity and mortality. Tumor mutational burden (TMB) is an emerging biomarker in cancer characterized by microsatellite instability. TMB has been described as a powerful predictor of tumor behavior and response to immunotherapy. Methods: A total of 443 bladder cancer samples obtained from The Cancer Genome Atlas (TCGA) were analyzed for mutation types, TMB values, and prognostic value of TMB. Differentially expressed genes (DEGs) were identified from the TMB groupings. Functional analysis was performed to assess the prognostic value of the first 30 core genes. CIBERSORT algorithm was used to determine the correlation between the immune cells and TMB subtypes. Results: Single nucleotide polymorphism (SNP) and C>T were reported as the most common missense mutations and we also identified a high rate of mutations in TP53, TTN, KMT2D. Bladder cancer patients with high TMB showed a better prognosis. Enrichment analysis of the DEGs revealed that they were involved in the regulation of the P13K-Akt signaling pathway, cytokine–cytokine receptor interaction, and Ras signaling pathway. The high expression of hub genes ADRA2A, CXCL12, S1PR1, ADAMTS9, F13A1, and SPON1 was correlated with poor overall survival. Besides, significant differences in the composition of the immune cells of T cells CD8, T cells CD4 memory activated, NK cells resting and Mast cells resting were observed. Conclusions: The present study provides a comprehensive and systematic analysis of the prediction of TMB in bladder cancer and its clinical significance. Also, the study provides additional prognostic information and opportunities for immunotherapy in bladder cancer.
Towards Convergence: How to Do Transdisciplinary Environmental Health Disparities Research

Increasingly, funders (i.e., national, public funders, such as the National Institutes of Health and National Science Foundation in the U.S.) and scholars agree that single disciplines are ill equipped to study the pressing social, health, and environmental problems we face alone, particularly environmental exposures, increasing health disparities, and climate change. To better understand these pressing social problems, funders and scholars have advocated for transdisciplinary approaches in order to harness the analytical power of diverse and multiple disciplines to tackle these problems and improve our understanding. However, few studies look into how to conduct such research. To this end, this article provides a review of transdisciplinary science, particularly as it relates to environmental research and public health. To further the field, this article provides in-depth information on how to conduct transdisciplinary research. Using the case of a transdisciplinary, community-based, participatory action, environmental health disparities study in California’s Central Valley provides an in-depth look at how to do transdisciplinary research. Working with researchers from the fields of social sciences, public health, biological engineering, and land, air, and water resources, this study aims to answer community residents’ questions related to the health disparities they face due to environmental exposure. Through this case study, I articulate not only the logistics of how to conduct transdisciplinary research but also the logics. The implications for transdisciplinary methodologies in health disparity research are further discussed, particularly in the context of team science and convergence science.