Miracle-dz/UniFAR-FTUs huggingface dataset:
The Role of Spirituality during Suicide Bereavement: A Qualitative Study

Background: A loved one’s loss due to suicide can be a traumatic experience and trigger a complex grief process. Although spirituality, defined as a search for the Sacred in a broad sense, can be a resource and an obstacle in coping with the suicide bereavement process, there is a gap in scientific understanding of the role spirituality plays during the process. Methods: To explore the role of spirituality in people bereaved by suicide, we recruited 11 women who lost a life partner due to suicide. We conducted semi-structured interviews and analyzed the data using reflexive thematic analysis. Results: We identified the following three themes: spirituality is a supportive resource that can be reached for or achieved without conscious involvement; spirituality provides helpful ways to cope with grief; spirituality makes the grief process more difficult. Conclusions: Spirituality, if personally meaningful and supported by others, can function as a resource after a loved one’s suicide and even add to post-traumatic growth after the loss. On the contrary, spirituality-related issues, such as stigmatization and a lack of personally meaningful traditions, can distress the bereaved. Difficult spiritual experiences and questions can become an intricate part of the grief process.
Prediction of Acute and Chronic Mastitis in Dairy Cows Based on Somatic Cell Score and Mid-Infrared Spectroscopy of Milk

Simple Summary Mid-infrared (MIR) spectroscopy is the method of choice to determine milk components like fat, protein and urea. We examined the potential of MIR spectra analyses for the prediction of clinical mastitis events of dairy cows additionally, or alternatively, to somatic cell count, which is routinely used as an indicator for mastitis monitoring. Prediction models based on MIR spectra and a somatic cell count-derived score (SCS) were developed and compared. A model based on MIR spectra and SCS proved more accurate at predicting mastitis than models based on either indicator alone. Consequently, MIR spectra analyses add extra value in the prediction of clinical mastitis, making them potentially useful for dairy farm management and as an auxiliary trait for the genetic evaluation of udder health. Abstract Monitoring for mastitis on dairy farms is of particular importance, as it is one of the most prevalent bovine diseases. A commonly used indicator for mastitis monitoring is somatic cell count. A supplementary tool to predict mastitis risk may be mid-infrared (MIR) spectroscopy of milk. Because bovine health status can affect milk composition, this technique is already routinely used to determine standard milk components. The aim of the present study was to compare the performance of models to predict clinical mastitis based on MIR spectral data and/or somatic cell count score (SCS), and to explore differences of prediction accuracies for acute and chronic clinical mastitis diagnoses. Test-day data of the routine Austrian milk recording system and diagnosis data of its health monitoring, from 59,002 cows of the breeds Fleckvieh (dual purpose Simmental), Holstein Friesian and Brown Swiss, were used. Test-day records within 21 days before and 21 days after a mastitis diagnosis were defined as mastitis cases. Three different models (MIR, SCS, MIR + SCS) were compared, applying Partial Least Squares Discriminant Analysis. Results of external validation in the overall time window (−/+21 days) showed area under receiver operating characteristic curves (AUC) of 0.70 when based only on MIR, 0.72 when based only on SCS, and 0.76 when based on both. Considering as mastitis cases only the test-day records within 7 days after mastitis diagnosis, the corresponding areas under the curve were 0.77, 0.83 and 0.85. Hence, the model combining MIR spectral data and SCS was performing best. Mastitis probabilities derived from the prediction models are potentially valuable for routine mastitis monitoring for farmers, as well as for the genetic evaluation of the trait udder health.
Theories of Polar Motion from Tisserand to Poincaré (1890 – 1910)

The discovery by Seth C. Chandler (1891) that the motion of the pole (the reality of which had been established by K.F. Kiistner and by the simultaneous latitude observations at Honolulu and Berlin by German astronomers) resulted from two components i.e. a free circular motion with a period of 427 days and a forced elliptical motion with a period of 365.25 days, raised considerable interest in the scientific community of astronomers and geophysicists. The celebrated Mecanique Celeste of Tisserand (1890) had been pub lished just one year before at a time when doubts still persisted and arguments could be presented in favor of the fixed pole. Starting with Tisserand's arguments, we describe in this paper the impact of the succes sive contributions by A. Greenhill, S. Newcomb, Th. Sloudsky, S. Hough, G. Herglotz, A. Love, J. Larmor and H. Poincare to the solution of the problems raised by the Chandler period. correct that, after about do not instead
Changes in the Regime of Erosive Precipitation on the European Part of Russia for the Period 1966–2020

The objective of this work is to analyze the spatial-temporal features of the trends in the frequency and amount of erosion-hazardous precipitation in the European part of Russia (EPR) for the period 1966–2020, as a reflection of the influence of climatic changes on surface runoff from the cultivated slopes during the warm season. One hundred and fifty-nine EPR weather stations were selected for analysis based on the length of the time series and the amount of missing data. Several characteristics of erosion-hazardous precipitation were considered: the number of days with a daily precipitation of more than 12.7 mm, the number of days with a daily precipitation of 12.7 to 40 mm, the number of days with a daily precipitation of more than 40 mm, the maximum one-day precipitation. In general, it can be stated that even within the southern taiga, mixed forests, and forest-steppe ecoregion (broad-leaved forests), within which a positive increase in the frequency of erosion-hazardous precipitation was detected, there was no significant increase in the rate of washout and linear washout, which is primarily due to a more significant reduction of slope runoff and soil washout during spring snowmelt. Precipitation, the daily amount of which is more than 40 mm, as well as the maximum daily amount of precipitation, show an upward trend in the western contact zone of mixed forests and forest-steppe, on the Black Sea coast, as well as in the northern foothills of the Caucasus, where their contribution to erosion processes is likely to increase against the decrease in the number of days with precipitation of a 12.7–40 mm daily amount.
Fifty Years of the Fluid–Mosaic Model of Biomembrane Structure and Organization and Its Importance in Biomedicine with Particular Emphasis on Membrane Lipid Replacement

The Fluid–Mosaic Model has been the accepted general or basic model for biomembrane structure and organization for the last 50 years. In order to establish a basic model for biomembranes, some general principles had to be established, such as thermodynamic assumptions, various molecular interactions, component dynamics, macromolecular organization and other features. Previous researchers placed most membrane proteins on the exterior and interior surfaces of lipid bilayers to form trimolecular structures or as lipoprotein units arranged as modular sheets. Such membrane models were structurally and thermodynamically unsound and did not allow independent lipid and protein lateral movements. The Fluid–Mosaic Membrane Model was the only model that accounted for these and other characteristics, such as membrane asymmetry, variable lateral movements of membrane components, cis- and transmembrane linkages and dynamic associations of membrane components into multimolecular complexes. The original version of the Fluid–Mosaic Membrane Model was never proposed as the ultimate molecular description of all biomembranes, but it did provide a basic framework for nanometer-scale biomembrane organization and dynamics. Because this model was based on available 1960s-era data, it could not explain all of the properties of various biomembranes discovered in subsequent years. However, the fundamental organizational and dynamic aspects of this model remain relevant to this day. After the first generation of this model was published, additional data on various structures associated with membranes were included, resulting in the addition of membrane-associated cytoskeletal, extracellular matrix and other structures, specialized lipid–lipid and lipid–protein domains, and other configurations that can affect membrane dynamics. The presence of such specialized membrane domains has significantly reduced the extent of the fluid lipid membrane matrix as first proposed, and biomembranes are now considered to be less fluid and more mosaic with some fluid areas, rather than a fluid matrix with predominantly mobile components. However, the fluid–lipid matrix regions remain very important in biomembranes, especially those involved in the binding and release of membrane lipid vesicles and the uptake of various nutrients. Membrane phospholipids can associate spontaneously to form lipid structures and vesicles that can fuse with various cellular membranes to transport lipids and other nutrients into cells and organelles and expel damaged lipids and toxic hydrophobic molecules from cells and tissues. This process and the clinical use of membrane phospholipid supplements has important implications for chronic illnesses and the support of healthy mitochondria, plasma membranes and other cellular membrane structures.
Mutual aid using digital technology: a case study of virtual community organizing during the COVID-19 pandemic

ABSTRACT This case study explored the evolution of a mutual aid network founded through virtual mediums and using digital technologies in response to the socio-economic impacts of the COVID-19 pandemic in the Boston, MA area. We collected qualitative interviews with the network’s founders and focus groups with active members. We assessed findings through a framework provided by Nelson, Ochocka, Griffin, and Lord which identified four key characteristics of mutual aid: learning as an ongoing process, supportive relationships, empowerment, and social change. We discuss the implications for using mutual aid as an approach to community organizing and activism in contemporary times and in the context of a public crisis.
Zebrafish Klf11b is Required to Maintain Cell Viability by Inhibiting p53-Mediated Apoptosis

Abstract Krüppel-like factor 10 (KLF10) regulates various cellular functions, such as proliferation, differentiation and apoptosis, as well as the homeostasis of several types of tissue. In the present study, we attempted a loss-of-function analysis of zebrafish Klf11a and Klf11b, which constitute human KLF10 homologs. Embryos injected with klf11b-morpholino (MO) showed developmental retardation and cell death, whereas klf11a-MO-injected embryos showed normal development. In klf11b-MO-injected embryos, a dramatic increase in the amount of zebrafish p53 mRNA might be the cause of the increase in that of bax. The degree of apoptosis decreased in the klf11b-MO and p53-MO co-injected embryos. These findings imply that KLF10 is a negative regulator of p53-dependent transcription, suggesting that the KLF10/p53 complex may play an important role in apoptosis for maintenance of tissue homeostasis during embryonic development.
Multivariate analyses of skull morphology inform the taxonomy and evolution of geomyoid rodents

Abstract Morphological analyses are critical to quantify phenotypic variation, identify taxa, inform phylogenetic relationships, and shed light on evolutionary patterns. This work is particularly important in groups that display great morphological disparity. Such is the case in geomyoid rodents, a group that includes 2 of the most species-rich families of rodents in North America: the Geomyidae (pocket gophers) and the Heteromyidae (kangaroo rats, pocket mice, and their relatives). We assessed variation in skull morphology (including both shape and size) among geomyoids to test the hypothesis that there are statistically significant differences in skull measurements at the family, genus, and species levels. Our sample includes 886 specimens representing all geomyoid genera and 39 species. We used the geometric mean to compare size across taxa. We used 14 measurements of the cranium and lower jaw normalized for size to compare shape among and within taxa. Our results show that skull measurements enable the distinction of geomyoids at the family, genus, and species levels. There is a larger amount of size variation within Geomyidae than within Heteromyidae. Our phylomorphospace analysis shows that the skull shape of the common ancestor of all geomyoids was more similar to the common ancestor of heteromyids than that of geomyids. Geomyid skulls display negative allometry whereas heteromyid skulls display positive allometry. Within heteromyids, dipodomyines, and non-dipodomyines show significantly different allometric patterns. Future analyses including fossils will be necessary to test our evolutionary hypotheses.
How the COVID-19 Pandemic Affected the Functioning of Tourist Short-Term Rental Platforms (Airbnb and Vrbo) in Polish Cities

The article presents the impact of the COVID-19 pandemic on urban tourism activity on short-term rental (STR) platforms in Central and Eastern Europe (CEE). It offers empirical evidence of how Airbnb and HomeAway (Vrbo) changed in Polish cities during the COVID-19 pandemic. A case study of Polish cities was also used to investigate what pandemic-induced scenarios of that impact are presented in the literature. In particular, the study identifies “loser” cities, in which the pandemic consolidated and deepened the decline in active STR volume, and “winner” cities, in which the volume and dynamics of the active STRs increased during the pandemic.
PANoptosis-like cell death in ischemia/reperfusion injury of retinal neurons

PANoptosis is a newly identified type of regulated cell death that consists of pyroptosis, apoptosis, and necroptosis, which simultaneously occur during the pathophysiological process of infectious and inflammatory diseases. Although our previous literature mining study suggested that PANoptosis might occur in neuronal ischemia/reperfusion injury, little experimental research has been reported on the existence of PANoptosis. In this study, we used in vivo and in vitro retinal neuronal models of ischemia/reperfusion injury to investigate whether PANoptosis-like cell death (simultaneous occurrence of pyroptosis, apoptosis, and necroptosis) exists in retinal neuronal ischemia/reperfusion injury. Our results showed that ischemia/reperfusion injury induced changes in morphological features and protein levels that indicate PANoptosis-like cell death in retinal neurons both in vitro and in vivo. Ischemia/reperfusion injury also significantly upregulated caspase-1, caspase-8, and NLRP3 expression, which are important components of the PANoptosome. These results indicate the existence of PANoptosis-like cell death in ischemia/reperfusion injury of retinal neurons and provide preliminary experimental evidence for future study of this new type of regulated cell death.
Prognostic Significance of Blood-Based Baseline Biomarkers in Treatment-Resistant Depression: A Literature Review of Available Studies on Treatment Response

Major depressive disorder is a leading cause of disability worldwide and a major contributor to the overall global burden of disease. While there are several options for antidepressant treatment, only about 40–60% of patients respond to initial monotherapy, while 30–40% of patients may even show resistance to treatment. This article offers a narrative review of those studies evaluating the predictive properties of various blood-based baseline biomarkers regarding treatment responses to the pharmacological, stimulation, or behavioral treatment of patients with treatment-resistant depression (TRD). Our results show that overall, there is only a very limited number of studies assessing baseline peripheral biomarkers regarding treatment response in TRD. Although there is some evidence for the predictive significance of particular biomarkers (e.g., IL-6, CRP, BDNF), the majority of the results are either single-study reports or studies with conflicting results. This may contribute to the wide variety of treatment protocols and different TRD definition criteria, the small number of patients included, and the existence of different biological phenotypes of the disorder used within the various studies. Taken together, there does not yet appear to be any specific baseline peripheral biomarker with sufficient discriminative predictive validity that can be used in the routine clinical practice of TRD. The discovery of new biomarkers and the better clinical characterization of known biomarkers could support the better classification and staging of TRD, the development of personalized treatment algorithms with higher rates of remission and fewer side effects, and the development of new precision drugs for specific subgroups of patients.
In Cellulo and In Vivo Comparison of Cholesterol, Beta-Sitosterol and Dioleylphosphatidylethanolamine for Lipid Nanoparticle Formulation of mRNA

Lipid Nanoparticles (LNPs) are a leading class of mRNA delivery systems. LNPs are made of an ionizable lipid, a polyethyleneglycol (PEG)-lipid conjugate and helper lipids. The success of LNPs is due to proprietary ionizable lipids and appropriate helper lipids. Using a benchmark lipid (D-Lin-MC3) we compared the ability of three helper lipids to transfect dendritic cells in cellulo and in vivo. Studies revealed that the choice of helper lipid does not influence the transfection efficiency of immortalized cells but, LNPs prepared with DOPE (dioleylphosphatidylethanolamine) and β-sitosterol were more efficient for mRNA transfection in murine dendritic cells than LNPs containing DSPC (distearoylphosphatidylcholine). This higher potency of DOPE and β-sitosterol LNPs for mRNA expression was also evident in vivo but only at low mRNA doses. Overall, these data provide valuable insight for the design of novel mRNA LNP vaccines.
The value of food products from mixed crop-livestock systems: environmental benefits and regional environmental carrying capacity

ABSTRACT Food products from mixed crop-livestock systems is a market-based solution to reduce environmental impacts of livestock worldwide. However, widespread promotion of mixed systems of recycling agriculture depends on consumers’ acceptance of its food products. In this paper, we examine consumers’ preferences and willingness to pay (WTP) for several attributes of pork products, and develop consumer classes based on preferences. Using a choice experiment among 893 Chinese consumers, our results show that consumers are willing to pay a premium for pork with mixed crop-livestock systems claim. In addition, a positive WTP is also detected for different environmental carrying capacity, environmental benefits and quality certifications. We use latent class analysis to identify heterogeneous consumers into five classes: namely balanced thinking, price sensitive, quality preferred, environmental benefits conscious and ecology conscious consumers. Further policies and interventions aimed at promoting the market-oriented operation of mixed crop-livestock systems of recycling agriculture, based on regional environmental carrying capacity, different dimensions of environmental benefits and quality improvement of food products, will be effective.
Effects of long‐term sewage sludge application to a calcareous soil structure

Soil degradation is a growing challenge to global agriculture and the United Nations' Sustainable Development Goals (SDGs). This has prompted calls for less use of mineral fertilizer and greater reliance on organic fertilizers. However, we need to understand better the long‐term effects of organic fertilizer usage on soil structure to guide soil management practice, as many soil functions are sensitive to pore morphology and connectivity. In this study, we characterized topsoil (0–30 cm) pore architecture in relation to soil physical properties in a long‐term experiment (LTE) site where calcareous soil had received 25 years of sewage sludge application. Two dosage rates (SSa, 20 and SSe, 80 Mg ha−1) were compared to mineral fertilization treatment and a control (no fertilization) in a random factorial block design. Soil microstructure and the types of pores were characterized using micromorphological methods and image analysis, in soil thin sections. Long‐term sewage sludge SSa application improved soil microstructure (crumb and sub‐angular‐blocky type) and increased the presence of biopores, while mineral fertilized soil showed a platy to apedal microstructure, with more elongated pores and lower faunal activity. Mineral fertilized soil had the lowest total porosity values, with differences found in the aspect ratio of pores of equivalent diameter 100–200 μm. These findings suggest a relation between the different types of fertilization and soil pore shape and network. Further exploration of these changes in soil functioning is needed for a complete assessment of the consequences of SS application.
Belief traps: Tackling the inertia of harmful beliefs

Significance Beliefs are a key element of healthy cognition. Yet overly rigid beliefs are the basis of societal problems including prejudices, psychiatric disorders, and conspiracy theories. Recent findings from neurobiology, psychiatry, and social sciences show how resilience of beliefs is boosted by stressful conditions. This implies the possibility of self-propelled societal deterioration where rigid beliefs harm the quality of personal and political decisions, evoking more-stressful conditions that further rigidify beliefs. Measures reducing social stress, including economic policies such as universal base income, may be the most effective ways to counteract this vicious cycle.
The Impact of Leaders’ Coaching Skills on Employees’ Happiness and Turnover Intention

This study seeks to provide a more comprehensive understanding of how leaders with coaching skills can affect an individual’s turnover intention through the mediating role of happiness. The sample includes 271 individuals from diverse organizations. Based on a survey, employees assessed their leaders’ coaching skills and reported their own happiness and turnover intention. The findings demonstrate that leaders’ coaching skills have a negative impact on employees’ turnover intention and a positive impact on their happiness, with the latter mediating the relationship between the first two variables. Organizations should note that a leader’s coaching skills are useful not only for the employee’s happiness, but also for avoiding turnover intention; therefore, organizations should encourage leaders to integrate more coaching skills into their leadership styles. The identification of an employee’s happiness as a mediator of the relationship between a leader’s coaching skills and employees’ turnover intention is an original contribution, thereby extending previous research over these topics.