Miracle-dz/UniFAR-FTUs huggingface dataset:
Role of Pretreatment Hemoglobin-to-Platelet Ratio in Predicting Survival Outcome of Locally Advanced Nasopharyngeal Carcinoma Patients

Background The three-year survival rate of locally advanced nasopharyngeal carcinoma (NPC) patients in Indonesia is lower than in other Asian countries. Calculation of hemoglobin-to-platelet ratio (HPR) may become a more practical predictor than the ratios using leukocyte cell components. Yet, no study has been conducted to investigate the potential of HPR in predicting survival outcomes in locally advanced nasopharyngeal cancer patients. Objective To determine the role of pretreatment hemoglobin-to-platelet ratio in predicting the three-year overall survival (OS) of locally advanced NPC. Method A retrospective cohort study followed up on 289 locally advanced NPC patients who had undergone therapy at the Dr. Cipto Mangunkusumo National General Hospital between January 2012 and October 2016. HPR cut-off was determined using ROC. Subjects were classified into two groups according to the HPR value. Kaplan-Meier curve was utilized to illustrate patients' three-year survival, and Cox regression test analyzed confounding variables to yield an adjusted hazard ratio (HR). Results The optimal cut-off for HPR was 0.362 (AUC 0.6228, 95% CI: 0.56-0.69, sensitivity 61.27%, specificity 60.34%). Of the subjects, 48.44% had HPR ≤ 0.362, and they had a higher three-year mortality rate than those with HPR > 0.362 (50% vs. 31.54%). In bivariate analysis, HPR ≤ 0.362 and age ≥ 60 significantly showed a worse three-year OS (p value = 0.003 and 0.075, respectively). In multivariate analysis, we concluded that a pretreatment HPR ≤ 0.362 was an independent negative predictor of three-year OS in locally advanced NPC patients (adjusted HR 1.82; 95% CI: 1.25–2.65). Conclusion Pretreatment HPR ≤ 0.362 was a negative predictor of three-year OS in locally advanced nasopharyngeal cancer patients.
Towards a Uniﬁed Framework for the UX Design of News Credibility Tools

In light of the proliferation of mis-and disinforma-tion on social media platforms, a number of tools and technological interventions have been developed that attempt to detect, verify, or evaluate digital news media at scale. Such ‘credibility tools’ provide labels or indicators that help users identify credible content and avoid deceptive media. Little is known about the efﬁcacy of such tools or how they are perceived by users; moreover, it is unclear whether such tools are united by common design principles and theories of online human behavior, or whether they reﬂect disparate assumptions. This study ﬁlls this gap in scholarly knowledge about credibility tools through an iterative mixed-methods UX research and design approach. Through interviews with both designers and users of credibility tools, usability studies, and survey experiments, we seek to formulate a common UX framework for the standardized design and development of digital news credibility tools. Bearing in mind the speciﬁc challenges that socially networked digital media and online attention dynamics pose for UX design, we name this the “UX of Credible Content” framework. From this framework, we plan to design a prototype of a credibility tool that synthesizes best UX practices and insights.
Unsteady chemical kinetics behavior of AP/HTPB propellant with micro-scale model

ABSTRACT The heterogeneous AP/HTPB propellant is a mixture of periodical units comprised of two AP (ammonium perchlorate, NH4ClO4) particles separated by a HTPB (hydroxyl-terminated polybutadiene) layer. So, the flame structure and the respond of the burning rate of such a material is resulted by an incredibly complex set of concurrent reactions taking place in the gas, liquid, and solid phases of a heterogeneous mixture, especially under unstable environment conditions. This article starts with a one-dimensional unstable chemical kinetics model to fix the respond of the burning rate to unstable conditions. Then, a two-dimensional micro-scale combustion model of ‘sandwich’ AP/HTPB propellant under unsteady-state conditions is explored to investigate the characteristic of microflame structure of this material and parameter distributions. It is demonstrated that for the periodic sandwich geometry a decrease in the environment pressure from 3 MPa to 2 MPa can sharply decrease the transient burning rate that is lower than the steady-state burning rate under corresponding pressure. Moreover, the temperature of the burning surface decreases when the depressurization process proceeds and the extinguishment will be considered to occur as the temperature of the burning surface is less than critical extinguishment temperature of 700 K. It is obtained from the two-dimensional, unsteady-state model that, when the depressurization rate is higher, the temperature of the burning surface decreases more sharply and the extinguishment phenomenon may occur.
The effect of Carum copticum L. and Salvia officinalis L. extracts on the physico-chemical, microbial, and sensory characteristics of treated-heat sausage during refrigerated storage

In the present research, 10, 20, and 30 mg kg-1 of Carum copticum extract, 40, 50, and 60 mg kg-1 of Salvia officinalis extract, and a combination of these extracts (15:30) were used as partial replacements of nitrite in the sausage formulation. Then, the physicochemical, microbial, and sensory tests were performed on all treatments and control sample (without any extract) over 45 days. The results showed that treatment with 60 mg kg-1 S. officinalis extract had the lowest pH value. The lowest peroxide value was related to treatment with 40 mg kg-1 S.officinalis extract, which showed a significant difference from the control sample (P< 0.05). The highest microbial count belonged to the control sample. Treatment with 60 mg kg-1 S. officinalis extract had the least total bacterial and Clostridium perfringens count. In contrast, the lowest count of coliform, mold, and yeast was found in treatment with 40 mg kg-1 S. officinalis extract. In terms of sensory attributes, treatment with 30 mg kg-1 C. copticum extract had the highest color and flavor scores, while the highest consistency and overall acceptance scores for all treatments were related to 20 and 10 mg kg-1 C. copticum extract, respectively. The results of this study showed that certain concentrations of C.copticum and S.officinalis extracts should be selected to achieve the optimal qualitative properties of sausage. In general, treatment with various concentrations of S. officinalis extract had better acceptance and improved the quality of the sausages. In conclusion, treatment containing 40 mg kg-1 S. officinalis extract was selected as a better treatment due to physicochemical, microbial, and sensory characteristics during cold storage.
CMOS Single Input Multiple Output Universal Biquad Filter Current-Mode Using Only OTAs

This paper presents a new single-input multiple-output universal biquad filter in current-mode with only four operational transconductance amplifiers (OTAs) and two grounded capacitors. The proposed filter can be obtained all filtering functions, low-pass, high-pass, band-pass, bandstop and all-pass filter that the transfer functions of the filter can be selected by choosing appropriate current output without any component matching conditions. The natural frequency and quality factor of all filtering functions can be controlled electronically and orthogonally using the bias currents of transconductance amplifiers. The active and passive sensitivities of the filters are low. The proposed filter has been simulated using 0.18 μm CMOS process from TSMC. PSPICE simulation results are included to confirm workability of the proposed circuits. Streszczenie. W niniejszym artykule przedstawiono nowy uniwersalny filtr biquad z pojedynczym wejściem i wieloma wyjściami w trybie prądowym z zaledwie czterema wzmacniaczami transkonduktancyjnymi (OTA) i dwoma uziemionymi kondensatorami. W proponowanym filtrze można uzyskać wszystkie funkcje filtrowania, dolnoprzepustowy, górnoprzepustowy, pasmowoprzepustowy, pasmowy i wszechprzepustowy, dzięki czemu funkcje przenoszenia filtra można wybrać poprzez wybór odpowiedniego wyjścia prądowego bez żadnych warunków dopasowania komponentów . Naturalną częstotliwość i współczynnik jakości wszystkich funkcji filtrowania można kontrolować elektronicznie i ortogonalnie za pomocą prądów polaryzacji wzmacniaczy transkonduktancyjnych. Aktywna i pasywna czułość filtrów jest niska. Proponowany filtr został zasymulowany przy użyciu procesu CMOS 0,18 μm firmy TSMC. Zawarto wyniki symulacji PSPICE, aby potwierdzić wykonalność proponowanych obwodów. (CMOS wielowyjściowy uniwersalny filtr dwukwadratowy prądowy wykorzystujący tylko OTA)
Mediation And Moderation Models on The Effect of Empowering Leadership and Professionalism Toward Lecturer Performance

This study aims to develop a conceptual model of the influence of leadership empowerment and professionalism on lecturer performance using work motivation as a mediating and moderating variable, self-efficacy, and locus of control as a moderating variable. Sampling used a cluster random sampling technique on 317 respondents from private university lecturers from Jambi and Riau Provinces which was carried out by sending a questionnaire via Google Form to the institutional email and then forwarded to the lecturer as a respondent. Data analysis was performed using Partial Least Square-Structural Equation Modeling with WarpPLS 7.0 software. The study's findings include that the fit and quality index models have validated their value; empowering leadership has a positive and significant effect on lecturer performance; professionalism has a positive but not significant effect on lecturer performance; work motivation has a positive and significant effect on lecturer performance; work motivation partially mediates the effect of empowering leadership on lecturer performance; work motivation fully mediates the effect of professionalism on lecturer performance; motivation weakens the effect of empowering leadership on lecturer performance but not significantly; work motivation can significantly strengthen the influence of professionalism on lecturer performance; self-efficacy weakens the effect of empowering leadership on lecturer performance but not significantly; locus of control can strengthen the influence of professionalism on lecturer performance but not significantly.
The Role of Control Perception of Behavior: The Influence of Social Networks and Entrepreneurship Education on Entrepreneured Intentions

Entrepreneurship has become an important focus of attention for all countries in the world including Indonesia. Even the number of entrepreneurs in a country can be used as a measure of the country's economic progress (Valliere and Peterson, 2009). The number of Indonesian entrepreneurs currently has reached 3.1% of the total 260 million people. However, this number is still below the percentage of entrepreneurs in neighboring countries such as Malaysia, reaching 5%, China 10%, Singapore 7%, and Japan 11% of the total population. Therefore, the Government of Indonesia needs to encourage its people to become entrepreneurs with quality, innovative and following technological developments. This study aims to determine the effect of social networks and entrepreneurship education on entrepreneurial intentions. In addition, this study also aims to examine the moderating role of perceived controlbehavior in strengthening the influence of social networks and entrepreneurship education on entrepreneurial intentions. The analysis technique used is SEM analysis with SMARTPLS 3.0 software. The study population was 540 undergraduate students majoring in Management in semester VI of the Faculty of Economics and Business, Warmadewa University Bali Indonesia. The sample was chosen randomly with a sample size of 170 respondents. The results of this study provide evidence that social networks have a positive and significant effect on intentionsentrepreneurial. Entrepreneurship education has a positive and insignificant effect on entrepreneurial intentions. The results of this study indicate that the role of perceptual behavior control strengthens the relationship between social networks and students' entrepreneurial intentions. Furthermore, this study succeeded in proving that the role of high perceptual behavior control when interacting with the increase in entrepreneurship education did not necessarily increase students' entrepreneurial intentions.
Response to the first reviewer comments (RC1)

The current trend toward larger wind turbine rotors leads to high periodic loads across the components due to the non-uniformity of inflow across the rotor. [. 2 ]To address this, we introduce a blade-mounted lidar on each blade to provide a preview of inflow wind speed that can be used as a feedforward control input for the mitigation of such periodic blade loads. We present a method to easily determine blade-mounted lidar parameters, such as focus distance, telescope position, and orientation on the blade. However, such a method is accompanied by uncertainties in the inflow wind speed measurement, which may also 5 be due to the induction zone, wind evolution, "cyclops dilemma", unidentified misalignment in the telescope orientation, and the blade segment orientation sensor. Identification of these uncertainties allows their inclusion in the feedback–feedforward controller development for load mitigation. We perform large-eddy simulations, in which we simulate the blade-mounted lidar including the dynamic behaviour and the induction zone of one reference wind turbine for one [. 3 ]above-rated inflow wind speed. Our calculation approach provides a good trade-off between a fast-and-simple determination of the telescope parameters 10 and an accurate inflow wind speed measurement. We identify and model the uncertainties, which then can directly be included in the feedback-feedforward controller design and analysis. The rotor induction effect increases the preview time, which needs to be considered in the controller development and implementation.
Antibiotics susceptibility profile of Metallo- beta-lactamase producing bacterial isolates harboring blaIMP and blaNDM genes from selected sachet water samples sold in Calabar Metropolis, Nigeria

Bacterial infections associated with metallo-beta-lactamase (MBL) production are often difficult to manage with existing antibiotics. This is as a result of the broad antibiotics hydrolytic spectrum of metallo-betalactamases which are known to hydrolyze all beta lactams except the monobactam antibiotics. this investigation was carried out to assess the antibiogram of metallo-beta-lactamase (MBL) producing bacteria from selected sachet water samples sold in Calabar Metropolis. Isolates from a previous study confirmed to harbour the blaIMP and blaNDM genes were subjected to antibiotics susceptibility testing following Clinical Laboratory Standard Institute guidelines. The antibiotics resistant spectrum of the MBL producing isolates were: Plesiomonas shigelloides strain 187 (OFX-CN-AU-CH-CAZ), Enterobacter cloacae strain S20504 (OFX-CN-AU-CH-S-CAZ), Photobacterium ganghwense strain ZR07 (CAZ), Bacillus licheniformis strain 60 (OFX-CN-AU-CH-S-AZT-CAZ), Klebsiella pneumoniae strain DSM 30104 (OFX-CN-AU-CH-S-SXT-CAZ), Plesiomonas spp strain TIL_TAL_1 (OFX-PEF-CN-AU-S-SXT-AZT-CAZ), Comamonas testosterone strain 1 (OFX-CN-AU-S-SXT-AZT-CAZ), Enterobacter sacchari SP1 (OFX-PEF-CN-AU-AM-CH-S-AZT), Acinetobacter soli strain MBR7 ( CAZ), Photobacterium ganghwense strain ZR07 (AZT-CAZ). The multiple antibiotics resistance indices (MARI) of the MBL producing isolates was in the range of 0.2-0.8. The multidrug resistance nature of these MBL producing isolates showed that they are a potential threat to health. Hence, measures to reduce the spread of these bacteria from the environment to human should be developed and implemented.
Construction Coordination in First and Second Language Acquisition

Repetition of linguistic forms is a pervasive coordination mechanism in interactive language use. In this paper, we investigate patterns of cross-participant repetition in dialogues where participants have different levels of linguistic ability. Achieving a better understanding of these patterns can not only shed light on how humans coordinate in conversation, but may also contribute to developing more natural and effective dialogue agents in education contexts related to language learning. Our approach is novel in several respects: We focus on multi-word constructions at the lexical and morphosyntactic level, consider both first and second acquisition dialogue, and contrast these setups with adult native conversation. The results of our study show that language acquisition scenarios are characterised by richer inventories of shared constructions but lower usage rates than fluent adult dialogues, and that shared construction use evolves as the linguistic ability of the learners increases, arguably leading to a process of routinisation.
Critical Performance Characteristics of the Nano ITC SV When Used in the Study of Complex Binding Reactions

Isothermal titration Calorimetry (ITC) has become one of the most powerful tools for characterizing the structure–function relationship for a wide variety of molecular binding events. The ability to generate thermodynamic data that defines the driving forces of a binding event provides signature characteristics that can be critical in fragment based drug design, biotherapeutic characterization and other process analysis steps where a subsequent toxicity or in vivo failure can be quite expensive.
Changes in Climatic Variables and Their Effect on Wheat Water Requirement in Urmia Lake Basin

Climate change and low water use efficiency are the main reasons for reducing the water entering the Urmia Lake. Therefore, water use management via irrigation scheduling can be an effective strategy to restore this lake. This research was conducted to investigate the effect of climatic variables on water requirements, identify water-sensitive growth stages, and prepare irrigation scheduling guidelines for wheat, which is one of the main crops in the studied region. For this purpose, crop Evapotranspiration (ETc) and Net Irrigation Requirement (NIR) of wheat growth stages were estimated by computing the daily soil water balance of the root zone for a period of 32 years (1985-1986 to 20162017). Dividing wheat growth period into nine phenological stages was performed using Growing Degree Days (GDDs) and Zadoks scale. These stages included intervals of [Sowing-Emergence (StE)], [Emergence-Trifoliate (EtT)], [Trifoliate-Double ridge (TtD)], [Double ridge-Jointing (DtJ)], [Jointing-Booting (JtB)], [Booting-Heading (BtH)], [Heading-Anthesis (HtA)], [Anthesis-Maturity (AtM)] and [Maturity-Harvesting (MtHa)], whose mean ETc was estimated to be 2.30, 1.33, 1.03, 3.63, 4.69, 5.13, 6.53, 7.09 and 1.35 mm d, respectively. The mean ETc, Effective Precipitation (Eff. P) and NIR of wheat during its growth period were estimated to be 774, 349, and 425 mm, respectively. Results showed that wheat sensitivity to water stress is high from booting to maturity, is low from sowing to double ridge and from maturity to harvesting, and is moderate in other stages. Therefore, increasing the irrigation interval in the first three stages of growth and eliminating the end-stage irrigation are recommended for water saving.
Real-time RT PCR Evaluation of the Xylitol Effect on the Expression of Streptococcus pneumoniae cpsB,cpsD and psaA Genes

Background and Aim: The major pneumococcal pathogenesis factor is the capsular polysaccharide. the production of polysaccharide is regulated by cpsB and cpsD genes. Thus, every agent that induce or inhibition of expression of these genes probably increased pathogenesis of bacteria, intracellular survival and vis versa. The aim of this study was to assay the effect of Xylitol on Streptococcus pneumoniae cpsB, cpsD, psaA and aroE genes expression by Real Time RT-PCR. Materials and Methods: During 2019 in Baqiyatallah university laboratories, 20 clinical isolates and a reference strain Streptococcus pneumoniae (ATCC 6305) were studied. To assay the effect of Xylitol and fructose، different concentration of these sugars were exposed to BHI Broth media. Thereafter, the bacterial suspension was added to 5% Xylitol, 5%Xylitol + 5% fructose and control medium for 3hours. RNA was extracted and cDNA synthesis was carried out. Then, the cpsB, cpsD and psaA genes expression levels were measured. Results: The mean of cpsB gene expression ratio in presence of the % 5 Xylitol treated media compared with those in the control media and % 5 Xylitol + 5% fructose were 0.022 and 0.027 respectively. The means of the cpsD and psaA genes expression ratio in the % 5 Xylitol treated media compared with those in the control media and % 5 Xylitol + 5% fructose were 1.659 and 0.056, and 0.633 and 3.294 respectively. Conclusion: Our finding revealed that, the 5% Xylitol inhibit the cpsB gene expression properly. Therefore, it is possible to use of Xylitol for reductive on cpsB gene expression and superficial pneumococcal infections control.
Integration Processes in Latin America: The Case of Mexico and Central America

After describing, within the framework of “Open Regionalism”, the tortuous process that the Central American countries have experienced to achieve their integration as a Common Market, this article analyses the relationship between these countries and Mexico, through the Free Trade Agreement signed among them. Once it is shown that the integration process of the Central American countries is on an impasse, the article explores the possibilities to advance on the economic integration between Mexico and the region. Using quantitative measurement and qualitative elements, this article identifies favorable conditions for such integration to be initiated by Mexico and Costa Rica, whether or not US trade policy changes towards the region.
Privacy-Preserving Federated Depression Detection From Multisource Mobile Health Data

Depression is one of the most common mental illnesses, and the symptoms shown by patients are different, making it difficult to diagnose in the process of clinical practice and pathological research. Although researchers hope that artificial intelligence can contribute to the diagnosis and treatment of depression, the traditional centralized machine learning methods need to aggregate patient data, and the data privacy of patients with mental illness needs to be strictly confidential, which hinders machine learning algorithms’ clinical application. To solve the problem of medical data privacy with depression, in this article, we implement a study of federated learning to analyze and diagnose depression. First, we propose a general multiview federated learning framework using multisource data, which can extend any traditional machine learning model to support federated learning across different institutions or parties. Second, we employ later fusion methods to solve the problem of inconsistent time series of multiview data. Finally, we compare the federated framework with other cooperative learning frameworks in performance and discuss the related results. The experimental results show that in the case of participating in federated learning with enough participants, the prediction accuracy of depression score can reach 85.13%, which is about 15% higher than local training. When the number of participants is small and the amount of data is sufficient, the prediction accuracy of depression score can also reach 84.32%, and the improvement rate is about 9%.