Miracle-dz/UniFAR-FTUs huggingface dataset:
L-DOPA increases slow-wave sleep duration and selectively modulates memory persistence in older adults

Introduction Millions of people worldwide take medications such as L-DOPA that increase dopamine to treat Parkinson’s disease. Yet, we do not fully understand how L-DOPA affects sleep and memory. Our earlier research in Parkinson’s disease revealed that the timing of L-DOPA relative to sleep affects dopamine’s impact on long-term memory. Dopamine projections between the midbrain and hippocampus potentially support memory processes during slow wave sleep. In this study, we aimed to test the hypothesis that L-DOPA enhances memory consolidation by modulating NREM sleep. Methods We conducted a double-blind, randomised, placebo-controlled crossover trial with healthy older adults (65–79 years, n = 35). Participants first learned a word list and were then administered long-acting L-DOPA (or placebo) before a full night of sleep. Before sleeping, a proportion of the words were re-exposed using a recognition test to strengthen memory. L-DOPA was active during sleep and the practice-recognition test, but not during initial learning. Results The single dose of L-DOPA increased total slow-wave sleep duration by approximately 11% compared to placebo, while also increasing spindle amplitudes around slow oscillation peaks and around 1–4 Hz NREM spectral power. However, behaviourally, L-DOPA worsened memory of words presented only once compared to re-exposed words. The coupling of spindles to slow oscillation peaks correlated with these differential effects on weaker and stronger memories. To gauge whether L-DOPA affects encoding or retrieval of information in addition to consolidation, we conducted a second experiment targeting L-DOPA only to initial encoding or retrieval and found no behavioural effects. Discussion Our results demonstrate that L-DOPA augments slow wave sleep in elderly, perhaps tuning coordinated network activity and impacting the selection of information for long-term storage. The pharmaceutical modification of slow-wave sleep and long-term memory may have clinical implications. Clinical trial registration Eudract number: 2015-002027-26; https://doi.org/10.1186/ISRCTN90897064, ISRCTN90897064.
Corchorus olitorius extract exhibit anti-hyperglycemic and anti-inflammatory properties in rodent models of obesity and diabetes mellitus

Obesity and type 2 diabetes (T2D) are chronic conditions with detrimental impacts on the overall health of individuals. Presently, the use of pharmacological agents in obesity and T2D offers limited benefits and pose side effects. This warrant studies on remedies that are less toxic and inexpensive while effective in ameliorating secondary complications in obesity and T2D. Plant-based remedies have been explored increasingly due to their remarkable properties and safety profile. We searched for pre-clinical evidence published from inception until 2023 on PubMed, Scopus, Google, and Semantic scholar on Corchorus olitorius (C. olitorius) in both obesity and T2D. Our focus was to understand the beneficial impact of this plant-based remedy on basic glycemic, lipid, inflammatory, and biomarkers of oxidative stress. The evidence gathered in this review suggests that C. olitorius treatment may significantly reduce blood glucose, body weight, total cholesterol, triglycerides, and low-density lipoprotein (LDL) in concomitant with increasing high-density lipoprotein-cholesterol (HDL-c) in rodent models of obesity and T2D. Interestingly, this effect was consistent with the reduction of malonaldehyde, superoxide dismutase and catalases, tumor necrosis factor-alpha, interleukins, and leptin. Some of the mechanisms by which C. olitorius reduces blood glucose levels is through stimulation of insulin secretion, increasing β-cell proliferation, thus promoting insulin sensitivity; the process which is mediated by ascorbic acid present in this plant. C. olitorius anti-hyperlipidemia is attributable to the content of ferulic acid found in this plant, which inhibits 3-Hydroxy-3-methyl glutaryl coenzyme A (HMG-CoA) reductase inhibitors and thus results in reduced synthesis of cholesterol and increased hepatic LDL-c receptor expression, respectively. The present review provides extensive knowledge and further highlights the potential benefits of C. olitorius on basic metabolic parameters, lipid profile, inflammation, and oxidative stress in rodent models of obesity and T2D.
Transcranial focused ultrasound selectively increases perfusion and modulates functional connectivity of deep brain regions in humans

Background Low intensity, transcranial focused ultrasound (tFUS) is a re-emerging brain stimulation technique with the unique capability of reaching deep brain structures non-invasively. Objective/Hypothesis We sought to demonstrate that tFUS can selectively and accurately target and modulate deep brain structures in humans important for emotional functioning as well as learning and memory. We hypothesized that tFUS would result in significant longitudinal changes in perfusion in the targeted brain region as well as selective modulation of BOLD activity and BOLD-based functional connectivity of the target region. Methods In this study, we collected MRI before, simultaneously during, and after tFUS of two deep brain structures on different days in sixteen healthy adults each serving as their own control. Using longitudinal arterial spin labeling (ASL) MRI and simultaneous blood oxygen level dependent (BOLD) functional MRI, we found changes in cerebral perfusion, regional brain activity and functional connectivity specific to the targeted regions of the amygdala and entorhinal cortex (ErC). Results tFUS selectively increased perfusion in the targeted brain region and not in the contralateral homolog or either bilateral control region. Additionally, tFUS directly affected BOLD activity in a target specific fashion without engaging auditory cortex in any analysis. Finally, tFUS resulted in selective modulation of the targeted functional network connectivity. Conclusion We demonstrate that tFUS can selectively modulate perfusion, neural activity and connectivity in deep brain structures and connected networks. Lack of auditory cortex findings suggests that the mechanism of tFUS action is not due to auditory or acoustic startle response but rather a direct neuromodulatory process. Our findings suggest that tFUS has the potential for future application as a novel therapy in a wide range of neurological and psychiatric disorders associated with subcortical pathology.
Assessment of transcriptional reprogramming of lettuce roots in response to chitin soil amendment

Chitin soil amendment is known to improve soil quality, plant growth and stress resilience, but the underlying mechanisms are not well understood. In this study, we monitored chitin’s effect on lettuce physiology every two weeks through an eight-week growth period, analyzed the early transcriptional reprogramming and related metabolomic changes of lettuce, in response to crab chitin treatment in peat-based potting soil. In commercial growth conditions, chitin amendment still promoted lettuce growth, increased chlorophyll content, the number of leaves and crop head weight from week six. The flavonoid content in lettuce leaves was altered as well, showing an increase at week two but a decrease from week six. Transcriptomic analysis showed that over 300 genes in lettuce root were significantly differentially expressed after chitin soil treatment. Gene Ontology-term (GO) enrichment analysis revealed statistical overrepresentation of GO terms linked to photosynthesis, pigment metabolic process and phenylpropanoid metabolic process. Further analysis of the differentially expressed genes (DEGs) showed that the flavonoid pathway was mostly upregulated whereas the bifurcation of upstream phenylpropanoid pathway towards lignin biosynthesis was mostly downregulated. Metabolomic analysis revealed the upregulation of salicylic acid, chlorogenic acid, ferulic acid, and p-coumaric acid in chitin-treated lettuce seedlings. These phenolic compounds (PCs) mainly influence the phenylpropanoid biosynthesis pathway and may play important roles in plant defense reactions. Our results suggest that chitin soil amendments might activate induced resistance by priming lettuce plants and promote lettuce growth via transcriptional changes.
Novel prognostic features and personalized treatment strategies for mitochondria-related genes in glioma patients

Background Gliomas are the most common intracranial nervous system tumours that are highly malignant and aggressive, and mitochondria are an important marker of metabolic reprogramming of tumour cells, the prognosis of which cannot be accurately predicted by current histopathology. Therefore, Identify a mitochondrial gene with immune-related features that could be used to predict the prognosis of glioma patients. Methods Gliomas data were downloaded from the TCGA database and mitochondrial-associated genes were obtained from the MITOCARTA 3.0 dataset. The CGGA, kamoun and gravendeel databases were used as external datasets. LASSO(Least absolute shrinkage and selection operator) regression was applied to identify prognostic features, and area and nomograms under the ROC(Receiver Operating Characteristic) curve were used to assess the robustness of the model. Single sample genomic enrichment analysis (ssGSEA) was employed to explore the relationship between model genes and immune infiltration, and drug sensitivity was used to identify targeting drugs. Cellular studies were then performed to demonstrate drug killing against tumours. Results COX assembly mitochondrial protein homolog (CMC1), Cytochrome c oxidase protein 20 homolog (COX20) and Cytochrome b-c1 complex subunit 7 (UQCRB) were identified as prognostic key genes in glioma, with UQCRB, CMC1 progressively increasing and COX20 progressively decreasing with decreasing risk scores. ROC curve analysis of the TCGA training set model yielded AUC (Area Under The Curve) values >0.8 for 1-, 2- and 3-year survival, and the model was associated with both CD8+ T cells and immune checkpoints. Finally, using cellMiner database and molecular docking, it was confirmed that UQCRB binds covalently to Amonafide via lysine at position 78 and threonine at position 82, while cellular assays showed that Amonafide inhibits glioma migration and invasion. Conclusion Our three mitochondrial genomic composition-related features accurately predict Survival in glioma patients, and we also provide glioma chemotherapeutic agents that may be mitochondria-related targets.
The retrospective study of the metabolic patterns of BCG-vaccination in type-2 diabetic individuals in COVID-19 infection

Background The cross-protective nature of Bacillus Calmette-Guerin (BCG) vaccine against SARS-CoV-2 virus was previously suggested, however its effect in COVID-19 patients with type 2 diabetes (T2D) and the underlying metabolic pathways has not been addressed. This study aims to investigate the difference in the metabolomic patterns of type 2 diabetic patients with BCG vaccination showing different severity levels of COVID-19 infection. Methods Sixty-seven COVID-19 patients were categorized into diabetic and non-diabetic individuals who had been previously vaccinated or not with BCG vaccination. Targeted metabolomics were performed from serum samples from all patients using tandem mass spectrometry. Statistical analysis included multivariate and univariate models. Results Data suggested that while BCG vaccination may provide protection for individuals who do not have diabetes, it appears to be linked to more severe COVID-19 symptoms in T2D patients (p = 0.02). Comparing the metabolic signature of BCG vaccinated T2D individuals to non-vaccinated counterparts revealed that amino acid (sarcosine), cholesterol esters (CE 20:0, 20:1, 22:2), carboxylic acid (Aconitic acid) were enriched in BCG vaccinated T2D patients, whereas spermidine, glycosylceramides (Hex3Cer(d18:1_22:0), Hex2Cer(d18:1/22:0), HexCer(d18:1/26:1), Hex2Cer(d18:1/24:0), HexCer(d18:1/22:0) were higher in BCG vaccinated non- T2D patients. Furthermore, data indicated a decrease in sarcosine synthesis from glycine and choline and increase in spermidine synthesis in the BCG vaccinated cohort in T2D and non-T2D groups, respectively. Conclusion This pilot study suggests increased severity of COVID-19 in BCG vaccinated T2D patients, which was marked by decreased sarcosine synthesis, perhaps via lower sarcosine-mediated removal of viral antigens.
Active tectonics and paleo-earthquakes in north Yumu Shan, northern Tibetan Plateau: Insights from structural analysis and radiocarbon dating

The Yumu Shan is located at the northern margin of the Tibetan Plateau in northwest China. It is characterized by the development of several northeastward-protruding arcuate geomorphic bulge belts on its north slope. These bulge belts are distributed along the Wutongquan spring, the ancient Camel City, and the Xiaogengzi area, and south to Gaotai City in the Hexi Corridor. In this study, our detailed field mapping and structural analysis reveal northeastward active anticline folding along the curved bulge belts and related lacustrine sediments in their hinterlands. Radiocarbon dating of plant charcoal samples from lacustrine sedimentary layers yields a 14C age of AD 178 ± 42. This age is close to the time of the 180AD/Ms7.5 earthquake at Biaoshi City (i.e., the ancient Zhangye City) during the Eastern Han Dynasty. The similarity between seismic events and sedimentary age leads us to infer that the charcoal in the lacustrine layer records a major flood event related to the Biaoshi earthquake. We propose a fault-related fold model for the formation of the arcuate bulge belts and related sediments. First, a series of historical earthquake activities in the Holocene, especially the 180AD/Ms7.5 Biaoshi earthquake, may have led to active blind thrust faulting in the northern margin of the plateau. Then, blind thrusting may have resulted in fault-related anticline folding, causing the formation of geomorphic bulges. The latter acts as a flood-retaining dam, resulting in hinterland deposition of lacustrine sediments. For this reason, we suggest that seismogenic blind thrust faulting is responsible for the uplift and northward growth of the Tibetan Plateau. As the northernmost blind thrust in this area, the Xiaogengzi Fault could be considered the North Boundary Thrust (NBT), which defines exactly the northern margin of the plateau.
RIPK1 in the inflammatory response and sepsis: Recent advances, drug discovery and beyond

Cytokine storms are an important mechanism of sepsis. TNF-α is an important cytokine. As a regulator of TNF superfamily receptors, RIPK1 not only serves as the basis of the scaffold structure in complex I to promote the activation of the NF-κB and MAPK pathways but also represents an important protein in complex II to promote programmed cell death. Ubiquitination of RIPK1 is an important regulatory function that determines the activation of cellular inflammatory pathways or the activation of death pathways. In this paper, we introduce the regulation of RIPK1, RIPK1 PANoptosome’s role in Inflammatory and sepsis, and perspectives.
Childhood trauma and problematic internet use: A meta-analysis based on students in mainland China

Background In recent years, the relationship between childhood trauma and problematic Internet use has been widely studied by scholars, but the research conclusions on the relationship between them are not consistent. Some studies report that childhood trauma and problematic Internet use are significantly correlated. However, others believe that there is a weak correlation between them. So the relationship between them needs to be studied further. The aim of this study is to explore the relationship between childhood trauma and problematic Internet use, and the effects of some moderating variables on both for students in Mainland China. Methods This study followed the requirements of Preferred Reporting Items for Systematic Review and Meta-analyses (PRISMA) statement for literature screening. We searched the related studies on childhood trauma and problematic Internet use in Mainland China from January 2009 to November 2022 from CNKI, Wanfang Data, Chongqing VIP Information Co., Ltd. (VIP), Baidu scholar, ProQuest dissertations, SAGE Online Journals, Elsevier SDOL, Taylor & Francis, Springer, Web of Science, Google Scholar, EBSCO, Medline, Scopus Database, PubMed Central, Embase, The Cochrane Library, PsycINFO, CMA 3.0 was used to analyse the overall effect and test the moderating effect. Results Among the papers included in the meta-analysis in this study, 31 papers reflected the relationship between childhood trauma and problematic Internet use, involving 52,503 subjects, and the sample size ranged from 388 to 16,130. This relationship between childhood trauma and problematic Internet use can be considered as a moderate correlation (r = 0.281, 95%CI[0.221, 0.338], p < 0.001). The results showed that the relationship between childhood trauma and problematic Internet use was affected by different problematic Internet use measures. Meanwhile, meta-regression demonstrated that the relationship between childhood trauma and problematic Internet use was moderated by survey’s year. Specifically, the correlation coefficient between childhood trauma and problematic Internet use also increases with increasing year. However, the relationship between childhood trauma and problematic Internet use was not affected by the region, grade, childhood trauma measures, publication source. Conclusion Childhood trauma is closely related to problematic Internet use. In order to reduce problematic Internet use, corresponding prevention and intervention measures should be taken.
Check the box! How to deal with automation bias in AI-based personnel selection

Artificial Intelligence (AI) as decision support for personnel preselection, e.g., in the form of a dashboard, promises a more effective and fairer selection process. However, AI-based decision support systems might prompt decision makers to thoughtlessly accept the system’s recommendation. As this so-called automation bias contradicts ethical and legal requirements of human oversight for the use of AI-based recommendations in personnel preselection, the present study investigates strategies to reduce automation bias and increase decision quality. Based on the Elaboration Likelihood Model, we assume that instructing decision makers about the possibility of system errors and their responsibility for the decision, as well as providing an appropriate level of data aggregation should encourage decision makers to process information systematically instead of heuristically. We conducted a 3 (general information, information about system errors, information about responsibility) x 2 (low vs. high aggregated data) experiment to investigate which strategy can reduce automation bias and enhance decision quality. We found that less automation bias in terms of higher scores on verification intensity indicators correlated with higher objective decision quality, i.e., more suitable applicants selected. Decision makers who received information about system errors scored higher on verification intensity indicators and rated subjective decision quality higher, but decision makers who were informed about their responsibility, unexpectedly, did not. Regarding aggregation level of data, decision makers of the highly aggregated data group spent less time on the level of the dashboard where highly aggregated data were presented. Our results show that it is important to inform decision makers who interact with AI-based decision-support systems about potential system errors and provide them with less aggregated data to reduce automation bias and enhance decision quality.
Theory of optical maser amplifiers

The interaction between an electromagnetic (em) pulse and a maser medium is described by a general set of five equations, under the assumption of a homogeneously broadened electric-dipole transition with two Bloch relaxation times T 2 and T 1 and of a linear broadband loss mechanism. When the equations are specialized at resonance, their solutions include the results of the previous treatments on the amplifier problem obtained under particular assumptions. The steady-state pulse (S. S. P.) introduced by Wittke and Warter for T_{2}/T_{1} = 0 is here generalized for T_{2}/T_{1} \neq 0 and it is shown to propagate at the same velocity of the light in the medium. In the case T_{2}/T_{1} = 0 the steady state is described by exact analytical relations. For times short in comparison to the relaxation times, a solution is given which generalizes the usual interaction formula between an em field and a two-level system by introducing propagation effects. In the general case out of resonance, it is shown that an S. S. P. exists, and that its frequency coincides with the frequency of the atomic transition, independent of the frequency of the input field.
Critical state and magnetization loss in multifilamentary superconducting wire solved through the commercial finite element code ANSYS

The commercially available finite element code ANSYS has been adapted to solve the critical state of single strips and multifilamentary tapes. We studied a special algorithm which approaches the critical state by an iterative adjustment of the material resistivity. Then, we proved its validity by comparing the results obtained for a thin strip to the Brand theory for the transport current and magnetization cases. Also, the challenging calculation of the magnetization loss of a real multifilamentary BSCCO tape showed the usefulness of our method. Finally, we developed several methods to enhance the speed of convergence, making the proposed process quite competitive in the existing survey of ac losses simulations.
Similarities between Stunted Outbursts in Nova‐like Cataclysmic Variables and Outbursts in Ordinary Dwarf Novae

Stunted outbursts have been reported in old novae and nova‐like cataclysmic variables by Honeycutt, Robertson, and Turner. These 0.4–1 mag outbursts were concluded to be either mass transfer events or disk outbursts similar to dwarf nova eruptions, but seen under unusual conditions. Honeycutt, Robertson, and Turner did not have enough evidence to favor either of these possibilities. This paper uses additional long‐term photometry and analysis to argue that the similarities of these stunted outbursts to dwarf nova eruptions are now so numerous that the dwarf nova outburst choice is strongly favored. The similarities discussed here include the range of outburst spacings, the coherence and stability of the outbursts, and the presence of isolated outburst/dip pairs. As part of this discussion we note the presence of unexpectedly stable clocks over 9 years for the repetition interval of dwarf nova outbursts in SY Cnc and of stunted outbursts in FY Per.
Reconstruction of the accretion disk in six cataclysmic variable stars

Four-color eclipse light curves of the nova-like variable stars RW Tri, UX UMa, SW Sex, LX Ser, V1315 Aql, and V363 Aur are analyzed with the maximum-entropy eclipse-mapping algorithm to reconstruct images of the accretion disks. The two-dimensional disk intensity maps deduced from the light curves reveal the size of the disk and its radial intensity dependence. The disk radius appears unrelated to the binary system parameters such as the orbital period, mass ratio and mass of the white dwarf. The position and luminosity of the bright spot are obtained from the intensity maps, and it is shown that the fractional luminosity of the bright spot is related to the ratio of the disk radius to the white-dwarf radius