Miracle-dz/UniFAR-FTUs huggingface dataset:
An Investigation of Barriers to Adopt Green Innovation Among Manufacturing Organizations in Vietnam

This research aims to identify the main barriers to green innovation in Vietnam manufacturing organizations. This study began by reviewing the relevant literature and providing a solid theoretical framework to understand the determinants of green innovation for manufacturing firms in the global context. It also helps internal and external stakeholders figure out what influence and how to implement green innovation more efficiently by removing all impediments. Additionally, this article is considered a valuable and rational evidence for prioritizing and directing innovation policies in the manufacturing industry. Based on numerical data from 143 employees at middleand upper-level managers among manufacturing companies around Vietnam, the study found that deficiency of financial resources primarily significantly impacts green innovation adoption, followed by the uncertainty of market demand and lack of government support. However, with limited observations, the investigation did not observe the dynamic effect of green innovation over periods and only focused on the manufacturing sector instead of different industries for generalizing the research results. Moreover, the circumstances of green innovation would be diverse in other nations. Keywords: green innovation, manufacturing organizations, government supports, financial barriers, market barriers
Paleoecology of a well-preserved nautiloid assemblage from a Late Ordovician shale unit, southwestern Ohio

A diverse, well-preserved assemblage of nautiloid cephalopods was collected from the Treptoceras duseri shale, a 1.5-m-thick claystone within the Waynesville Formation (Late Ordovician, early Richmondian) exposed in southwest Ohio. The strata, the enclosed fauna, and its taphonomy indicate deposition in a low-energy, mud-bottom marine environment, in water depths of 20–25 m, below wave base but within the zone of storm-current reworking. Nautiloid specimens consist of complete conchs that have been replaced by calcite. Twelve species of nautiloids, belonging to eight genera, representative of four orders, have been collected from the shale in southwest Ohio. Longiconic orthocones are clearly the dominant nautiloid morphotype present, with the assemblage dominated by three species of the longiconic orthocerid Treptoceras and with fewer numbers of the endocerid Cameroceras and the slender orthocerid Isorthoceras? , the cyrtoconic oncocerids Oncoceras and Manitoulinoceras, and rare specimens of the orthocerid Gorbyoceras, the oncocerid Zittelloceras, and the ascocerid Schuchertoceras. Nautiloid taphonomy, the diversity of nautiloid taxa present, the lack of postmortem buoyancy in the shells of the more common taxa, the recurrent nature of this assemblage, and the restricted distribution of this Treptoceras–Cameroceras fauna to portions of eastern North America in the Late Ordovician suggest that this nautiloid assemblage represents an in-situ accumulation of nautiloids representative of a living assemblage. These nautiloids were important elements associated with benthic communities in these epeiric sea mud-bottom environments and not simply assemblages of drifted, necroplanktonic shells.
Health and Quality of Life Outcomes

Childhood epilepsy is one of the most important and prevalent neurological conditions in the developing years. Persons with childhood onset epilepsy are at a high risk for poor psychosocial outcomes, even without experiencing co-morbidities. The goal of management of children with epilepsy should be to enable the child and the family to lead a life as free as possible from the medical and psychosocial complications of epilepsy. This comprehensive care needs to go beyond simply trying to control seizures with minimal adverse drug reactions. Seizure frequency and severity is only one important outcome variable. Other factors such as social, psychological, behavioural, educational, and cultural dimensions of their lives affect children with epilepsy, their families and their close social networks. A number of epilepsy-specific health-related quality of life (HRQL) scales for children have been developed with the aim to include and measure accurately the impact and burden of epilepsy. Their target populations, details of the origin of the items, and psychometric properties vary significantly. Their strengths and weaknesses will be identified more clearly through their continued use in the clinical setting and in research studies. Only a few studies to date have utilized these or generic HRQL measures to assess the HRQL of specific populations with epilepsy. Future research needs to develop theory driven models of HRQL and identify measurable factors that have important correlations with outcomes. Since biomedical variables like seizure frequency and severity have only moderate correlations with HRQL, other independent factors including the child's resilience, co-morbid conditions, parental well-being, family factors and societal/cultural variables may play a major role. We also need to learn what encompasses comprehensive patient care, define the goals of management and evaluate the impact of different interventions. Future studies need to include the children's own perspectives of their HRQL in addition to parental reports. Finally, clinicians need to familiarize themselves with outcome measures, be able to evaluate them, and use them routinely in their day-to-day practice. Published: 28 August 2003 Health and Quality of Life Outcomes 2003, 1:36 Received: 15 July 2003 Accepted: 28 August 2003 This article is available from: http://www.hqlo. com/content/1/1/36 © 2003 Ronen et al; licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL.
Digital economy drives regional industrial structure upgrading: Empirical evidence from China’s comprehensive big data pilot zone policy

With the development of the digital economy, industrial structure upgrading plays an important role in realizing high-quality development. Exploiting the quasi-natural experimental setting provided by the Big Data Comprehensive Pilot Zone (BDCPZ) policy in China in 2016, this study evaluates the impacts of the BDCPZ policies on regional industrial structure upgrading using a combination of propensity score matching and difference-in-differences (PSM-DID) with panel data of 30 regions for the period 2008–2021. The results are as follows: (1) BDCPZ policies significantly promote regional industrial structure upgrading. This finding holds after conducting the placebo test and replacing explained variables. (2) BDCPZ policies enhance upgrading through technological innovation and financial deepening. (3) Heterogeneity analysis shows that the promotional effect of BDCPZ policies on industrial structure upgrading is more obvious in economically developed regions, megacities, and east-central regions; overall, regions with high industrialization benefit more. These findings have important implications: First, they provide new empirical evidence from the perspective of policy evaluation on how the digital economy affects industrial structure upgrading. Second, this study sheds light on the mechanism underlying this relationship, helping us understand how the digital economy can further affect the development of the industrial structure. Third, the policy effect is heterogenous, providing a scientific basis for the government to formulate differentiated implementation policies for different regions. This can help local industrial transformation and upgrading, and economic development in these regions through the implementation of big data and digital technologies.
The Difference of Interleukin-6 Level and Seroma Volume Between Quilting and Conventional Suture After Modified Madical Mastectomy

Background: Modified radical mastectomy is the standard surgical therapy for locally advanced breast cancer (LABC). Seroma as the most common complication after MRM has many morbidities. Quilting suture after MRM to prevent dead space consistently decreased seroma formation on many studies. However, it is not widely applied in Indonesia. Interleukin-6 (IL-6) on the other hand has also been known to affect seroma production. However, the correlation between these two has not been well studied. Objective: To know the difference of IL-6 level and seroma volume between quilting and conventional suture after MRM in LABC. Methods: This study is a randomized controlled trial conducted from April to July 2022 with permuted block randomization which allocated samples that suited the inclusion and exclusion criteria into intervention group (quilting suture) and control group (conventional suture). Results: The average difference of total seroma volume between the two groups were 399.25 mL (p=0.000). The average difference of Interleukin-6 level between the two groups was 3160.75 mL (p=0.000). The result of linear regression shows that the total time needed for wound closure (p=0.029; 95%CI: 183.291 – 592.605) and the quilting technique (p=0.018; 95%CI: 1727.971- -8101.730) were two variables that affected the level of IL-6 in the seroma and were statistically significant. Adjusted R2 value was 0.118 indicating the effect of the two variables on the change of seroma volume was 11.8%. Conclusion: Quilting suture significantly reduced the total volume of seroma as well as the IL-6 level in the seroma after MRM in LABC. IL-6 level was also significantly affected by the duration needed for wound closure.
Effects of high-intensity functional training on physical fitness and sport-specific performance among the athletes: A systematic review with meta-analysis

Objective This study aims to meta-analyze the impact of high-intensity functional training on athletes’ physical fitness and sport-specific performance. Methods A systematic search was conducted in five well-known academic databases (PubMed, Scopus, Web of Science, EBSCOhost, and the Cochrane Library) up to July 1, 2023. The literature screening criteria included: (1) studies involving healthy athletes, (2) a HIFT program, (3) an assessment of outcomes related to athletes’ physical fitness or sport-specific performance, and (4) the inclusion of randomized controlled trials. The Physical Therapy Evidence Database (PEDro) scale was used to evaluate the quality of studies included in the meta-analysis. Results 13 medium- and high-quality studies met the inclusion criteria for the systematic review, involving 478 athletes aged between 10 and 24.5 years. The training showed a small to large effect size (ES = 0.414–3.351; all p < 0.05) in improving upper and lower body muscle strength, power, flexibility, and sport-specific performance. Conclusion High-intensity functional training effectively improves athletes’ muscle strength, power, flexibility, and sport-specific performance but has no significant impact on endurance and agility. Future research is needed to explore the impact of high-intensity functional training on athletes’ speed, balance, and technical and tactical performance parameters.
Evaluation of the QoS policy model of an ordinary 5G smart city cluster with predominant URLLC and eMBB traffic

A typical element of the smart city’s information and communication space is a 5G cluster, which is focused on serving both new and handover requests because it is an open system. In an ordinary 5G smart city cluster, Ultra-Reliable Low-Latency Communications (URLLC) and enhanced Mobile BroadBand (eMBB) traffic types prevail. The formation of an effective QoS policy for such an object (taking into account the potentially active slicing technology) is an urgent problem. As a baseline, this research considers a Quality of Service (QoS) policy with constraints for context-defined URLLC and eMBB classes of incoming requests. Evaluating the QoS policy instance defined within the framework of the basic concept requires the formalization of both a complete qualitative metric and a computationally efficient mathematical apparatus for its calculation. The article presents accurate and approximate methods of calculating such quality parameters as the probability of loss of typed requests and the utilization ratio of the communication resource, which depend on the implementation of the estimated QoS policy. At the same time, the original parametric space includes both fixed characteristics (amount of available communication resources, load according to request classes) and controlled characteristics due to the specifics of the implementation of the basic QoS concept. The paper empirically proves the adequacy of the presented mathematical apparatus for evaluating the QoS policy defined within the scope of the research. Also, in the proposed qualitative metric, a comparison of the author’s concept with a parametrically close analogue (the well-known QoS policy scheme, which takes into account the phenomenon of reservation of communication resources), determined taking into account the reservation of communication resources, was made. The results of the comparison testify in favour of the superiority of the author’s approach in the proposed metrics.
tRNA m1G9 modification depends on substrate-specific RNA conformational changes induced by the methyltransferase Trm10

The methyltransferase Trm10 modifies a subset of tRNAs on the base N1 position of the 9th nucleotide in the tRNA core. Trm10 is conserved throughout Eukarya and Archaea, and mutations in the human gene (TRMT10A) have been linked to neurological disorders such as microcephaly and intellectual disability, as well as defects in glucose metabolism. Of the 26 tRNAs in yeast with guanosine at position 9, only 14 are substrates for Trm10. However, no common sequence or other posttranscriptional modifications have been identified among these substrates, suggesting the presence of some other tRNA feature(s) which allow Trm10 to distinguish substrate from nonsubstrate tRNAs. Here, we show that substrate recognition by Saccharomyces cerevisiae Trm10 is dependent on both intrinsic tRNA flexibility and the ability of the enzyme to induce specific tRNA conformational changes upon binding. Using the sensitive RNA structure-probing method SHAPE, conformational changes upon binding to Trm10 in tRNA substrates, but not nonsubstrates, were identified and mapped onto a model of Trm10-bound tRNA. These changes may play an important role in substrate recognition by allowing Trm10 to gain access to the target nucleotide. Our results highlight a novel mechanism of substrate recognition by a conserved tRNA modifying enzyme. Further, these studies reveal a strategy for substrate recognition that may be broadly employed by tRNA-modifying enzymes which must distinguish between structurally similar tRNA species.
Effect of rootstock on the growth and yielding of 'Jojo' plum trees in an ecological orchard

In 2005-2009 period, in a 5-year-old ecological orchard, a study was conducted of the growth and yielding of 'Jojo' plum trees grafted on Myrobalan Plum seedlings and Wangenheim Prune seedlings. On both these rootstocks, the plum trees began to bear fruit already in the second year after planting. In the last three years they blossomed abundantly, but in 2007 there was no fruit crop to collect because all the flowers had been destroyed by spring frosts. The trees grafted on Myrobalan seedlings were growing markedly stronger than those on Wangenheim Prune seedlings, but the latter were more productive. The fruits were analyzed in terms of soluble solids content and total acidity. Some of the fruits in the ecological orchard were affected by brown rot disease (Monilinia laxa Aderh. et Uhl.). The type of rootstock did not have an effect on the degree of intensity of the disease, nor on the number of fruits with the larvae of the plum moth (Laspeyresia funebrana Tr.). The characteristic reddening of the flesh surrounding the stone, and of the stone itself, was found in this plum cultivar to occur more frequently on the trees grafted on Wangenheim Prune seedlings than those on Myrobalan seedlings. The study is in its initial stages and will be continued.
Immune checkpoint inhibitors as potential therapy for reverting T-cell exhaustion and reverting HIV latency in people living with HIV

The immune system of people living with HIV (PLWH) is persistently exposed to antigens leading to systemic inflammation despite combination antiretroviral treatment (cART). This inflammatory milieu promotes T-cell activation and exhaustion. Furthermore, it produces diminished effector functions including loss of cytokine production, cytotoxicity, and proliferation, leading to disease progression. Exhausted T cells show overexpression of immune checkpoint molecules (ICs) on the cell surface, including programmed cell death protein 1 (PD-1), cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4), T-cell immunoglobulin and mucin-domain containing-3 (TIM-3), T-cell immunoglobulin and immunoreceptor tyrosine-based inhibitory motif domain (TIGIT), and lymphocyte activation gene-3 (LAG-3). The ICs also play a crucial role in T-cell exhaustion by reducing the immune response to cancer antigens. Immunotherapy based on immune checkpoint inhibitors (ICIs) has changed the management of a diversity of cancers. Additionally, the interest in exploring this approach in the setting of HIV infection has increased, including AIDS-defining cancers and non-AIDS-defining cancers in PLWH. To date, research on this topic suggests that ICI-based therapies in PLWH could be a safe and effective approach. In this review, we provide an overview of the current literature on the potential role of ICI-based immunotherapy not only in cancer remission in PLWH but also as a therapeutic intervention to restore immune response against HIV, revert HIV latency, and attain a functional cure for HIV infection.
Spatial variation and predictors of missing birth preparedness and complication readiness (BPCR) messages in Ethiopia

Background The Birth Preparedness and Complication Readiness (BPCR) message is one of the prenatal care packages targeted at reducing maternal and neonatal mortality by avoiding unnecessary delays during labor and delivery. There is limited evidence in Ethiopia that has looked at the spatial variation of missing BPCR messages and potential predictors. Hence, this study aimed to identify spatial predictors missing BPCR messages at the national level. Methods The study was based on analysis of 2016 Ethiopia Demographic Health Survey data, using a weighted sample of 4771 women. Arc-GIS version 10.7 and SaTScan version 9.6 statistical software were used for the spatial analysis. To explore spatial variation and locate spatial clusters of missing BPCR messages, the Global Moran’s I statistic and Bernoulli-based spatial scan (SaTScan) analysis were carried out, respectively. Hotspot (Getis-OrdGi*) analysis was conducted to identify Hotspots and Cold spotsof missing BPCR messages. Finally, spatial regression were carried out via ordinary least squares and geographically weighted regression to identify predictors of hotspots for missing BPCR messages. Results The overall prevalence of missing BPCR messages in Ethiopia was found to be 44.0% (95%CI: 42.6, 45.4%), with significant spatial variation across regions (Moran’s I = 0.218, p-value<0.001) and seven most likely significant SaTScan clusters. The vast majority of Somali, central Afar, and Gambella regions were identified as statistically significant hotspots. Living in the poorest wealth quintile, having only one ANC visit, lack of access to listening to the radio, facing difficulty in accessing money, not having a mobile phone, and being not covered by health insurance were identified as significant spatial predictors of missing BPCR messages. Conclusion The level of missing BPCR messages during pregnancy was found to be high in Ethiopia, with significant local variation. As a result, policymakers at the national level and local planners should develop strategies and initiatives that enhance women’s economic capacities, health-seeking behavior, and media exposure. Furthermore, the regional authorities should focus on strategies that promote universal health coverage through enrolling citizens in health insurance schemes.
Alterations in Resting-State Functional Connectivity and Dynamics in Schizophrenia as a Result of Global not Local Processes

We examined changes in large-scale functional connectivity and temporal dynamics and their underlying mechanisms in schizophrenia (ScZ) through measurements of resting-state functional magnetic resonance imaging (rs-fMRI) data and computational modelling. The rs-fMRI measurements from patients with chronic ScZ (n=38) and matched healthy controls (n=43), were obtained through the public schizConnect repository. Computational models were constructed based on diffusion-weighted MRI scans and fit to the experimental rs-fMRI data. We found decreased large-scale functional connectivity across sensory and association areas and for all functional subnetworks for the ScZ group. Additionally global synchrony was reduced in patients while metastability was unaltered. Perturbations of the computational model revealed that decreased global coupling and increased background noise levels both explained the experimentally found deficits better than local changes to the GABAergic or glutamatergic system. The current study suggests that large-scale alterations in ScZ are more likely the result of global rather than local network changes.