Miracle-dz/UniFAR-FTUs huggingface dataset:
First 100 minimally invasive liver resections in a new tertiary referral centre for liver surgery

Background: In the last decades, there has been an exponential diffusion of minimally invasive liver surgery (MILS) worldwide. The aim of this study was to evaluate our initial experience of 100 patients undergoing MILS resection comparing their outcomes with the standard open procedures. Materials and Methods: One hundred consecutive MILS from 2016 to 2019 were included. Clinicopathological data were reviewed to evaluate outcomes. Standard open resections were used as the control group and compared exploiting propensity score matching. Results: In total, 290 patients were included. The rate of MILS has been constantly increasing throughout years, representing the 48% in 2019. Of 100 (34.5%) MILS patients, 85 could be matched. After matching, the MILS conversion rate was 5.8% (n = 5). The post-operative complication rates were higher in the open group (45.9% vs. 31.8%, P = 0.004). Post-operative blood transfusions were less common in the MILS group (4.7% vs. 16.5%, P = 0.021). Biliary leak occurred in 2 (2.4) MILS versus 13 (15.3) open. The median comprehensive complication index was higher in the open group (8.7 [0–28.6] vs. 0 [0–10.4], P = 0.0009). The post-operative length of hospital stay was shorter after MILS (median 6 [5–8] vs 8 [7–13] days, P < 0.0001). Conclusions: The rate of MILS has been significantly increasing throughout the years. The benefits of MILS over the traditional open approach were confirmed. The main advantages include lower rates of post-operative complications, blood transfusions, bile leaks and a significantly decreased hospital stay.
Assessment of Infection control knowledge and Attitude related to Needle stick Injuries among nursing staff

Background: The Needle stick Injuries (NSI) are among the incidents which risk the safety of health care workers in the hospital and healthcare setup. Health care professionals (HCP) are at greater risk of exposure to the blood and body fluids. Hepatitis B virus (HBV) transmission rate by NSI is estimated to be around 33.3%, followed by Hepatitis C virus 3.3% and HIV 0.3%. Aim of the study: assess of infection control knowledge, attitude and resources related to needle stick injuries among nursing staff. Research design: Descriptive research design was used in this study. Setting: This study will be conducted at Beni suif University Hospital. Sample: includes all nurses in four critical care units in the hospital N= (68). Tool: three tools were used in the current study. First tool : knowledge regarding needle stick injury , second tool :Attitude of nurses toward needle stick injures and third tool : hospital resources. Results: the participated nurses had good knowledge and negative attitude toward needle stick injury and there are correlation between knowledge and their attitude and availability of hospital resources with needle stick injury . Conclusions: This study accentuates that there was significant correlation between knowledge and each of attitude and availability of hospital resources with needle stick injury . Recommendation: in-service training program for staff nurses about standard of infection control precautions. Healthcare institutions should apprise themselves of developments in hospital resources and safety devices, e.g. needle-less technology and reduce risk within their organization or modify work practices that pose a needle stick injury hazard to make them safer. Key wards: Attitude, Knowledge, Needle stick injuries, staff nurses.
Long-term Prognostic Value of Homocysteine in Patients with Acute Coronary Syndrome Complicated with Hypertension: A Multicenter Retrospective Study

Background and aims: This study investigates the long-term prognostic value of homocysteine in patients with acute coronary syndrome complicated with hypertension. Methods:The current work is a multicenter, retrospective, observational cohort study. We consecutively enrolled 1288 ACS patients hospitalized in 11 general hospitals in Chengdu, China, from June 2015 to December 2019. The patients were divided into hypertension and non-hypertension groups, and each was further classified into hyperhomocysteinemia (H-Hcy) and normal homocysteinemia (N-Hcy) groups according to the cut-off value of homocysteine predicting long-term mortality during follow-up. In both groups, we used Kaplan-Meier and multivariate Cox regression analysis to assess the relationship between homocysteine and long-term prognosis. Results: The median follow-up time was 18 months (range: 13.83-22.37). During this period, 78 (6.05%) death cases were recorded. The hypertension was further divided into H-Hcy (n=245) and N-Hcy (n=543), with an optimal cut-off value of 16.81 µmol/L. Similarly, non-hypertension was further divided into H-Hcy (n=200) and N-Hcy (n=300), with an optimal cut-off value of 14 µmol/L. Kaplan-Meier survival curves revealed that H-Hcy had a significantly lower survival probability than N-Hcy, both in hypertension and non-hypertension (P-value<0.01). After adjusting for confounding factors, multivariate Cox regression analysis revealed that H-Hcy (HR=2.1923, 95% CI: 1.213-3.9625, P＜0.01) was an independent predictor of long-term all-cause death in ACS with hypertension, but not in non-hypertension.Conclusion: Elevated homocysteine level predicts risk of all-cause mortality in ACS with hypertension, but not in those without hypertension. it should be considered when determining risk stratification for ACS, particularly those complicating hypertension.
Chromium.

Two oxidation states of chromium are considered to be biologically and environmentally relevant based on their stability in the presence of water and oxygen. Compounds containing chromium(6 + ) are mutagenic and carcinogenic when inhaled and potentially when ingested orally in large quantity as well. Chromium as the trivalent will be the focus of this work as it was proposed to be an essential element for mammals ∼60 y ago; however, in the last 2 decades its status has been questioned. Chromium has been postulated to be involved in regulating carbohydrate and lipid (and potentially also protein) metabolism by enhancing insulin's efficacy (1). However, in 2014, the European Food Safety Authority found no convincing evidence that chromium is an essential element (2). Dietary chromium apparently is absorbed via passive diffusion and the extent of absorption is low (∼1%). Chromium is maintained in the bloodstream bound to the protein transferrin. It is generally believed to be delivered to tissues by transferrin via endocytosis (1). No unambiguous animal model of chromium deficiency has been established (2). One limitation in characterizing chromium deficiency in humans is the lack of an accepted biomarker of chromium nutritional status. Attempts to identify a glucose tolerance factor have not provided a chemically defined functional compound that conforms with the proposed physiologic role of chromium as a facilitator of insulin action in vivo.
Microsatellite allelic heterogeneity among hatchery rainbow trout maturing in different seasons

Allele frequencies were determined at 14 microsatellite loci in 284 female and 50 male rainbow trout that were sampled throughout the spawning season from a commercial trout farm. Phenotypic selection has expanded the spawning season of the broodstock from 2 weeks to 8 months. Females maturing in different seasons showed significantly different allelic distributions (P<0.001) at all loci. The spawning time for the majority of females sampled could be predicted based on their genotypic information [chromosome segment sharing coefficient (CSSC) values]. CSSC analyses assigned 100, 56, 76 and 68% of summer, fall, winter, and spring spawning females, respectively to the season from which their gametes were actually collected. Alternatively, only 38 and 14% of summer and spring spawning XY males respectively, were assigned to the correct season, Loci linked to thermal tolerance and spawning time quantitative trait loci (QTL) showed significantly greater heterogeneity (higher average D s values) in allele frequencies than those not known to be linked to QTL based on previous work. Thus, phenotypic selection for spawning time has led to concomitant changes in allele frequencies at markers of QTL. This suggests that the QTL detected in our previous work have detectable effects in fish from other genetic backgrounds.
Estimation of Genetic Correlations of Primal Cut Yields with Carcass Traits in Hanwoo Beef Cattle

Simple Summary Recently, there is a growing interest in the genetic improvement of carcass merit in the Korean beef industry. Primal cut yields have been proposed to characterize the meat quality and quantity in beef cattle and are known to be genetically correlated with the carcass merit and premium prices. Hence, knowledge of genetic parameters is required to select the weight of primal cuts that may be used as the selection criteria for designing future breeding programs. This study aimed to estimate the heritability and genetic and phenotypic correlations of primal cut yields and carcass traits in Hanwoo cattle. All traits presented a medium to high heritability, which indicates a probable increase in their response to selection. In addition, moderate to highly favorable genetic correlations were found between the primal cut yields and carcass traits, such as the carcass weight and eye muscle area. Therefore, results suggested inclusion of primal cut traits as a selection objective in Hanwoo breeding programs to meet the growing demand for high quality products. Abstract This study was carried out to estimate the variance components, heritability, and genetic correlations between the carcass traits and primal cut yields in Hanwoo cattle. Carcass traits comprising 5622 records included back fat thickness (BFT), carcass weight (CW), eye muscle area (EMA), and marbling score (MS). The 10 primal cut yields from 3467 Hanwoo steers included the tenderloin (TLN), sirloin (SLN), striploin (STLN), chuck (CHK), brisket (BSK), top round (TRD), bottom round (BRD), rib (RB), shank (SK), and flank (FK). In addition, three composite traits were formed by combining primal cut yields as novel traits according to consumer preferences and market price: high-value cuts (HVC), medium-value cuts (MVC), and low-value cuts (LVC). Heritability estimates for the interest of traits were moderate to high, ranging from 0.21 ± 0.04 for CHK to 0.59 ± 0.05 for MS. Except genetic correlations between RB and other primal cut traits, favorable and moderate to high correlations were observed among the yields of primal cut that ranged from 0.38 ± 0.14 (CHK and FK) to 0.93 ± 0.01 (TRD and BRD). Moreover, the estimated genetic correlations of CW and EMA with primal cut yields and three composite traits were positive and moderate to strong, except for BFT, which was negative. These results indicate that genetic progress can be achieved for all traits, and selection to increase the yields of primal cuts can lead to considerable profitability in the Hanwoo beef industry.
Effectiveness of additional income for ASN at BKPSDMD Makassar City

Essentially, awarding the Employee with Additional employee Income (TPP) is expected to improve the welfare and performance of ASN to support development in Makassar and to provide better public services in Makassar. Therefore, this study aims to find out the Effectiveness of Providing Additional Employee Income (TPP), especially for ASN at BKPSDMD Makassar City, whether it has been effective in improving ASN performance or not. The research method used in this research is descriptive qualitative and descriptive quantitative data to optimize the result of the research findings. Interviews, observation, questionnaires, and document reviews are used to collect the data. The data analysis technique collects the data from the results of interviews, observations, questionnaires, and document reviews which are then presented systematically in descriptive form. The result shows that providing additional employee income (TPP) for ASN at BKPSDMD Makassar City has been effective, especially in improving the welfare of ASN. On the contrary, it is ineffective in terms of employee discipline. This is because the Leaders at BKPSDMD Makassar City do not set an excellent example regarding discipline. Moreover, Leaders are expected to set a good example of discipline and supervise the ASN.
THE EFFECT OF FINANCIAL LITERACY, PARENTAL SOCIALIZATION AND PEERS INFLUENCE ON SAVING BEHAVIOR AND THE ROLE OF FINANCIAL ATTITUDES AS A MEDIATING VARIABLE IN THE MILLENNIAL GENERATION OF WORKERS IN THE CITY OF PALEMBANG

The development and progress of the financial market today makes the millennial generation increasingly need knowledge and competence in managing their finances in order to allocate funds appropriately and behave in saving. The purpose of this study is to analyze the influence of financial literacy, parental socialization and peer influence on saving behavior and the role of financial attitude as a mediation of financial literacy on saving behavior. This study applies the use of electronically distributed online questionnaires for data collection. The method used in this study is quantitative analysis using Structural Equation Modeling (SEM), while the Sobel test is used to measure the mediation test. The results showed that financial literacy and parental socialization had a significant effect on saving behavior, while peer influence had no significant effect, but the financial attitude variable was able to mediate financial literacy and saving behavior. This study pays attention to the policies of financial institutions that have been targeted to encourage financial literacy, which is mostly achieved by literacy and informing the millennial generation of Palembang city workers in managing finances.
Emerging Trends in Sustainability Reporting (SR): Comparative Literature Review in Developed, Developing and GCC Countries

This paper aims to investigate the emergence and practices of sustainability reporting (SR) in developed, developing and GCC countries, as well as the various users of sustainability reports. To gain thorough insights on the regulatory guidelines that govern SR practices, the paper deeds the SR standards and related frameworks. Furthermore, the paper looks at SR motivations to ascertain the impact of stakeholders, regulations, and rankings on SR practices of a company. Profoundly, a review of literature on SR practices in developed, developing and GCC countries is conducted to identify and substan-tiate an academic research gap. The major findings of this paper contribute to displaying that the extent of SR reporting motives and practices is pointedly differentiated between developed, developing and GCC countries due to cultural factors, legitimacy concerns and country-level perspectives, however GCC countries have gained enhanced impetus due to the legislative nature of pri-vate and public industries.
Pharmacokinetics and bioavailability of midazolam in rats following single dose administration of intravenous solution, intranasal dispersion, and in situ nasal gel

Midazolam (MDZ) is used as a sedative and anxiolytic agent in pediatric operations or dentistry procedures. Considering low solubility in physiologic pH, commercial intravenous MDZ formulation is constructed as an acidic solution, which is unofficially used orally, rectally, buccally, and intranasally in spite of low patient compliance due to irritation, inflammation, and caustic effect at administration sites. Due to the pathological safety of our previously designed MDZ poloxamer nasal gel (MDZ-PLX-GEL), its pharmacokinetic parameters were determined and compared to MDZ aqueous dispersion (MDZ-DIS) after intranasal administration in rats. MDZ-PLX-GEL was prepared using PLX (22% w/v), MDZ (1% w/v), and propylene glycol (10% v/v) in phosphate buffer pH 6. For better comparison, the commercial intravenous solution was evaluated as well. MDZ was analyzed using a validated high-performance liquid chromatography method. Male Sprague Dawley rats were used for in vivo experiments. The most important feature of MDZ-PLX-GEL was a rapid onset (20 minutes) with a mean residence time (MRT) of 170 minutes, which means MDZ effective blood concentration (100–200 ng/ml) lasts 3 hours which could increase MDZ-PLX-GEL absolute bioavailability up to 66.5%±4.6%. It was confirmed that the thermosensitive poloxamer gel was a suitable nasal carrier for MDZ that could increase its residence time, which may be a proper alternative for the currently unofficial routes of MDZ administration.
Concentrations of Mg, Ca, Fe, Cu, Zn, P and anthropometric and biochemical parameters in adults with chronic heart failure

Background The study investigated the relationship between the concentrations of Mg, Ca, Fe, Cu, Zn, P and anthropometric and biochemical parameters in the blood serum of patients with heart failure (HF) and the potential influence on the development and progression of HF. Material & methods The study included 214 patients (155 men and 59 women), aged 40–87 years, presenting symptoms or signs typical of HF (according to the NYHA functional classification). Serum concentrations were determined for Mg, Ca, Fe, Cu, Zn, P, C-reactive protein (CRP), creatinine, urea, triglyceride levels (TG), total cholesterol (CH), high density protein (HDL), low density protein (LDL). The levels of macro-and microminerals were analysed using inductively coupled serum optical emission spectrometry (ICP-OES). Results Our study confirmed the role of known risk factors in the development of heart failure, including: overweight, diabetes, hypertension, high triglycerides (TG), high total cholesterol (CH), high levels of low density protein (LDL) and reduced levels of high density protein (HDL), high CRP, high creatinine. Moreover, deficient serum concentrations of Mg (47% of the studied men and 54% of the women) and Cu (in 44% of men and more than 30% of women) were observed, as well as subnormal serum Fe (2% of women) and Zn (1% of men). Elevated serum Ca was found in 50% of men and 49% of women. In 44% of the studied men and 52% of the studied women, P levels in serum were also above-average. The study revealed a significant positive correlation between serum levels of Ca and Mg, and also Ca and Cu in women. In men, serum Cu was positively correlated with Mg and Ca concentrations. In patients from group 1 (NYHA I–II), Mg content was positively correlated with Ca and Cu. In this patient group, Ca was also positively associated with Cu content in serum. In group 2 (NYHA III-IV), serum Mg concentration was significantly positively correlated with that of Cu and Ca. Conclusions Changes in the serum concentrations of macro-and microminerals may significantly affect the severity of HF in Polish patients.
Heating of carbonaceous materials: Insights into the effects of thermal metamorphism on spectral properties of carbonaceous chondrites and asteroids

Carbonaceous chondrites (CCs) are important materials for understanding the early evolution of the solar system and delivery of organic material to the early Earth. Spectral analysis of CCs can establish the relationship between them and their possible parent asteroids, which helps to determine the surface composition of the asteroid. In this paper, the 0.3–26 μm reflectance spectra of a series of coals ranging from lignite to anthracite (Earth analogs of organic matter contained in CCs), a coal heated to various durations and temperatures, and reflectance spectra of CM2 meteorites were analyzed in conjunction with compositional information to derive spectral–compositional relationships. All types of coals have strong aromatic absorptions (3.28 and 5–6.5 μm) and aliphatic “triplet” absorptions (3.38, 3.41, and 3.48 μm). In contrast, CM2 meteorites have obvious aliphatic absorptions and lack aromatic absorptions. The reason is the weak absorption coefficients of aromatic materials and the overlap with strong OH/H2O absorption. Absorptions in the coal spectra are strongly related to elemental H/C ratio. When the H/C ratio is >0.55, the absorption intensity of an aliphatic increases linearly with the increase of H/C. For heated coal, increasing heating time above 1 h at 450 °C causes the disappearance of the aliphatic “triplet” absorptions. Similarly, heating Murchison meteorite to 400 °C for 1 week causes all the organic absorptions to disappear. This implies that in remote sensing detections, only asteroids (e.g., with CM and CI carbonaceous chondrites compositions) that experienced low thermal metamorphism (<400 °C) are suitable as potential targets for detecting organic compounds using features in the 3–4 µm region.
Long-Term Patterns and Trends of Shortwave Global Irradiance over the Euro-Mediterranean Region

The spatiotemporal patterns and trends of shortwave global irradiance (SWGI) are a crucial factor affecting not only the climate but also sectors of the economy. In this work, the ERA5-Land reanalysis dataset is employed and evaluated against in situ measurements from a dense network of surface stations operated by the National Observatory of Athens over Greece, revealing a good agreement between the two datasets. Then, the spatiotemporal variability of SWGI is investigated over the Euro-Mediterranean region (10° W–42° E and 30° N–52° N) for a 40-year period (1981–2020). SWGI exhibits a smooth latitudinal variability from north to south of −5.4 W/m2/degree on an annual scale, while it varies significantly on a seasonal basis and is almost four times lower in the winter than in the summer. The SWGI trend during the analyzed period was found to be positive and statistically significant at the 95% confidence level. Spring and summer are the periods where positive and the strongest rates of SWGI trends are evident, while in the winter and autumn, negative or neutral trends were found. The increasing SWGI trend shows a slowdown during the beginning of the 2000s in all seasons, except autumn. The SWGI trend decreases by about −0.06 W/m2/decade every 100 m of elevation increase.
Melvin

protease inhibitor (PI) therapy in utero on cord blood lipids in infants born to mothers enrolled in AIDS Clinical Trials Group protocol 5084, a prospective, multicentre, observational study of antiretroviral therapy (ART) during pregnancy. Methods: Clinical outcome was determined in 80 infants born to women treated with PIs and 73 infants born to women treated with other antiretrovirals during pregnancy. Cord blood serum from 117 of these infants was assayed for total, low-density lipoprotein (LDL) and high-density lipoprotein (HDL) cholesterol, triglyceride, apolipoprotein A1 (apoA1), apolipoprotein B100 (apoB) and lipoprotein (a). Covariates considered in the analysis included race/ethnicity, gestational age, infant gender, infant birth weight, mode of delivery, maternal tobacco and alcohol use, post-partum body mass index, and ART duration. Results: Cord blood total and HDL cholesterol, triglyceride, apoA1, apoB, lipoprotein (a) and apoB/apoA1 ratio were not different between the two groups. Cord blood lipid levels in these HIV-exposed infants were similar to those reported in other neonatal cohorts. Controlling for race/ethnicity, infants born to women treated with PIs had higher LDL cholesterol than those born to women not treated with PIs (29 mg/dl versus 27 mg/dl, P=0.006). Conclusion: Only LDL cholesterol was significantly higher in the cord blood of PI-exposed infants versus those not exposed to PIs in utero. As the difference between the two groups was small, the clinical relevance of the effect of maternal PI treatment on infant LDL cholesterol levels at birth is not clear. Original article