Miracle-dz/UniFAR-FTUs huggingface dataset:
A GWAS in Latin Americans identifies novel face shape loci, implicating VPS13B and a Denisovan introgressed region in facial variation

We carried out a genome-wide association study in Latin Americans and identified novel face morphology loci. To characterize the genetic basis of facial features in Latin Americans, we performed a genome-wide association study (GWAS) of more than 6000 individuals using 59 landmark-based measurements from two-dimensional profile photographs and ~9,000,000 genotyped or imputed single-nucleotide polymorphisms. We detected significant association of 32 traits with at least 1 (and up to 6) of 32 different genomic regions, more than doubling the number of robustly associated face morphology loci reported until now (from 11 to 23). These GWAS hits are strongly enriched in regulatory sequences active specifically during craniofacial development. The associated region in 1p12 includes a tract of archaic adaptive introgression, with a Denisovan haplotype common in Native Americans affecting particularly lip thickness. Among the nine previously unidentified face morphology loci we identified is the VPS13B gene region, and we show that variants in this region also affect midfacial morphology in mice.
Denitrifying pathways dominate nitrous oxide emissions from managed grassland during drought and rewetting

Isotopic measurements showed that N2O production during drought is unexpectedly dominated by denitrification of organic nitrogen. Nitrous oxide is a powerful greenhouse gas whose atmospheric growth rate has accelerated over the past decade. Most anthropogenic N2O emissions result from soil N fertilization, which is converted to N2O via oxic nitrification and anoxic denitrification pathways. Drought-affected soils are expected to be well oxygenated; however, using high-resolution isotopic measurements, we found that denitrifying pathways dominated N2O emissions during a severe drought applied to managed grassland. This was due to a reversible, drought-induced enrichment in nitrogen-bearing organic matter on soil microaggregates and suggested a strong role for chemo- or codenitrification. Throughout rewetting, denitrification dominated emissions, despite high variability in fluxes. Total N2O flux and denitrification contribution were significantly higher during rewetting than for control plots at the same soil moisture range. The observed feedbacks between precipitation changes induced by climate change and N2O emission pathways are sufficient to account for the accelerating N2O growth rate observed over the past decade.
Migratory earthquake precursors are dominant on an ice stream fault

Migratory nucleation of earthquakes is dominant, and self-nucleation is rare over many repeats of a natural stick-slip cycle. Simple fault models predict earthquake nucleation near the eventual hypocenter (self-nucleation). However, some earthquakes have migratory foreshocks and possibly slow slip that travel large distances toward the eventual mainshock hypocenter (migratory nucleation). Scarce observations of migratory nucleation may result from real differences between faults or merely observational limitations. We use Global Positioning System and passive seismic records of the easily observed daily ice stream earthquake cycle of the Whillans Ice Plain, West Antarctica, to quantify the prevalence of migratory versus self-nucleation in a large-scale, natural stick-slip system. We find abundant and predominantly migratory precursory slip, whereas self-nucleation is nearly absent. This demonstration that migratory nucleation exists on a natural fault implies that more-observable migratory precursors may also occur before some earthquakes.
School Principals’ Time Use for Interaction with Individual Students: Macro Contexts, Organizational Conditions, and Student Outcomes

To test emerging narratives of principals’ direct effect on student outcomes on a large scale, this study investigates whether school principals’ time use for interacting with individual students is associated with academic achievement and student safety at school. Built on recent research on principals’ time use, this study explores whether economic, sociocultural, and institutional features of societies influence the amount of time principals spend interacting with individual students. This time use, in turn, is assumed to be associated with academic achievement and safety at school. To explore the linkages, the study utilizes the Progress in International Reading Literacy Study (PIRLS) with multilevel modeling. Implications of the findings are offered for an emerging inquiry on principals’ direct effect on student outcomes and for US education policy.
2020 Clinical Update in Liver Transplantation

The gold standard treatment of end-stage liver disease continues to be liver transplantation (LT). The challenges of LT require skilled anesthesiologists to anticipate physiologic changes associated with end-stage liver disease (ESLD) as well as surgical considerations that affect multiple organ systems. While on the waiting list, patients may be placed new anticoagulation medications that can confound already complex coagulopathy in LT patients. Pain management is often an afterthought for such a complex procedure but appropriate medications can help control pain while limiting opioid medications. Surgical stress and medications for immunosuppression can affect perioperative glucose management in ways that have implications for patient and graft survival. 2020 provided a new challenge for anesthesiologist, the COVID-19 pandemic. The uncertainty of the novel respiratory virus challenged providers in beyond just LT patients.
Memory for Past Events

and pets. These positive relationships provided the children with opportunities to demonstrate their abilities, which were recognized and affirmed by others. In some instances, they served as a buffer against bullies because friends supported and defended children when they were victimized. The findings of this study are consistent with a social model of disability (Thomas, 2004) that includes three dimensions: impairment effects, barriers to doing, and barriers to being which involves people with disabilities feeling lesser by the words or actions of nondisabled people. In this study, impairment effects could be difficulty saying words; barriers to doing were exclusion and frustration when the children were not understood by others (barriers to doing); and barriers to being involved internalizing negative evaluations by others (barriers to being).
Healthy Pediatric Athletes Have Significant Baseline Limb Asymmetries on Common Return-to-Sport Physical Performance Tests

Background: Return to sport (RTS) after anterior cruciate ligament (ACL) reconstruction in children is associated with a much higher risk (∼30%) of subsequent ACL injury than in adults. Most RTS testing protocols use a limb symmetry index (LSI) ≥90% on physical performance tests (PPTs) to assess an athlete’s readiness for sport. This assumes that, in a healthy state, the physical performances across both lower extremities are and should be equal. Purpose: To determine the prevalence of limb asymmetries >10% in the uninjured pediatric population on common PPTs as well as to explore the relationship between athlete variables, limb preference, and LSI values. Study Design: Cross-sectional study; Level of evidence, 3. Methods: This study included healthy volunteers (N = 100) evenly distributed between the ages of 6 and 18 years (mean age, 11.7 ± 3.6 years; 52% female). Participants performed 9 common PPTs. For analysis, we developed a composite score for each limb by averaging trials. We then calculated the LSI for each test. Univariable and multivariable linear regression analyses were performed to assess the relationship between athlete variables (age, sex, height, and weight) and LSI for each PPT. Results: Instances of poor baseline limb symmetry (<90% LSI) were common across all PPTs. The single-leg timed hop had the highest percentage of participants, with LSI ≥90% at 73%, while the stork on a Bosu ball had the lowest percentage at 23%. After adjusting for age, female sex showed a significant association with LSI for the stork test (P = .010) and the quadrant hop–counterclockwise (P = .021). Additionally, after adjusting for sex, increasing age showed a significant association with LSI for the stork test (P < .001), single-leg squat on a Bosu ball (P = .010), quadrant hop–clockwise (P = .016), and quadrant hop–counterclockwise (P = .009). Conclusion: The majority of healthy athletes 18 years and younger demonstrated significant (<90%) limb asymmetries. Limb symmetry was not consistently affected by participant age or sex, and the effect sizes of these relationships were small. These findings should encourage clinicians and coaches to exercise caution in using the LSI as an isolated measure of RTS readiness after injury in pediatric athletes.
Subjective Outcome Evaluation of a Positive Youth Development Program in Mainland China

Objectives: This study validated a 36-item Subjective Outcome Evaluation Scale (SOES) and examined the effectiveness of a positive youth development (PYD) program entitled “Tin Ka Ping Positive Adolescent Training through Holistic Social Programs” (TKP P.A.T.H.S. Project) and implemented in mainland China in the 2016–2017 and 2017–2018 academic years. Methods: We collected data from 20,480 students from 30 secondary schools in mainland China on their views toward program quality, implementer quality, and program benefits based on the SOES. Results: The SOES possessed good factorial, convergent, discriminant, and concurrent validities as well as internal consistency. Besides, the student respondents were generally satisfied with the program quality, implementer quality, and program benefits. Consistent with our hypothesis, junior grade students had more positive perceptions than did senior grade students. Conclusion: Utilizing the client satisfaction approach, this study validated the SOES and highlighted the value of PYD programs exemplified by the TKP P.A. T.H. S. Program in a non-Western context.
Restoration of the Posterior Glenoid in Recurrent Posterior Shoulder Instability Using an Arthroscopically Placed Iliac Crest Bone Graft: A Computed Tomography–Based Analysis

Background: Posterior shoulder instability is uncommon, and its treatment is a challenging problem. An arthroscopically assisted technique for posterior iliac crest bone grafting (ICBG) has shown promising short- and long-term clinical results. Changes as shown on imaging scans after posterior ICBG for posterior shoulder instability have not been investigated in the recent literature. Purpose: To evaluate changes on computed tomography (CT) after arthroscopically assisted posterior ICBG and to assess clinical outcomes. Study Design: Case series; Level of evidence, 4. Methods: Patients with preoperative CT scans and at least 2 postoperative CT scans with a minimum follow-up of 2 years were included in the evaluation. Of 49 initial patients, 17 (follow-up rate, 35%) met the inclusion criteria and were available for follow-up. We measured the glenoid version angle and the glenohumeral and scapulohumeral indices on the preoperative CT scans and compared them with measurements on the postoperative CT scans. Postoperatively, graft surface, resorption, and defect coverage were measured and compared with those at early follow-up (within 16 months) and final follow-up (mean ± SD, 6.6 ± 2.8 years). Results: The mean preoperative glenoid version was –17° ± 13.5°, which was corrected to –9.9° ± 11.9° at final follow-up (P < .001). The humeral head was able to be recentered and reached normal values as indicated by the glenohumeral index (51.8% ± 6%; P = .042) and scapulohumeral index (59.6% ± 10.2%; P < .001) at final follow-up. Graft surface area decreased over the follow-up period, from 24% ± 9% of the glenoid surface at early follow-up to 17% ± 10% at final follow-up (P < .001). All clinical outcome scores had improved significantly. Progression of osteoarthritis was observed in 47% of the shoulders. Conclusion: Arthroscopically assisted posterior ICBG restored reliable parameters as shown on CT scans, especially glenoid version and the posterior subluxation indices. Graft resorption was common and could be observed in all shoulders. Patient-reported clinical outcome scores were improved. Osteoarthritis progression in almost 50% of patients is concerning for the long-term success of this procedure.
Advances in the Estimation of Global Surface Net Heat Flux Based on Satellite Observation: J-OFURO3 V1.1

The reliability of surface net heat flux data obtained from the latest satellite-based estimation [the third-generation Japanese Ocean Flux Data Sets with Use of Remote Sensing Observations (J-OFURO3, V1.1)] was investigated. Three metrics were utilized: (1) the global long-term (30 years) mean for 1988–2017, (2) the local accuracy evaluation based on comparison with observations recorded at buoys located at 11 global oceanic points with varying climatological characteristics, and (3) the physical consistency with the freshwater balance related to the global water cycle. The globally averaged value of the surface net heat flux of J-OFURO3 was −22.2 W m−2, which is largely imbalanced to heat the ocean surface. This imbalance was due to the turbulent heat flux being smaller than the net downward surface radiation. On the other hand, compared with the local buoy observations, the average difference was −5.8 W m−2, indicating good agreement. These results indicate a paradox of the global surface net heat flux. In relation to the global water cycle, the balance between surface latent heat flux (ocean evaporation) and precipitation was estimated to be almost 0 when river runoff from the land was taken into consideration. The reliability of the estimation of the latent heat flux was reconciled by two different methods. Systematic ocean-heating biases by surface sensible heat flux (SHF) and long wave radiation were identified. The bias in the SHF was globally persistent and especially large in the mid- and high latitudes. The correction of the bias has an impact on improving the global mean net heat flux by +5.5 W m−2. Furthermore, since J-OFURO3 SHF has low data coverage in high-latitudes areas containing sea ice, its impact on global net heat flux was assessed using the latest atmospheric reanalysis product. When including the sea ice region, the globally averaged value of SHF was approximately 1.4 times larger. In addition to the bias correction mentioned above, when assuming that the global ocean average of J3 SHF is 1.4 times larger, the net heat flux value changes to the improved value (−11.3 W m−2), which is approximately half the original value (−22.2 W m−2).
Case Report: Neoadjuvant PD-1 Blockade Plus Concurrent Chemoradiotherapy in Unresectable Locally Advanced Gastric Cancer Patients

Programmed death 1(PD-1) blockade has shown promising efficacy in advanced gastric cancer. Here, we performed a retrospective analysis of three patients with locally advanced gastric cancer who received adjuvant PD-1 plus chemoradiotherapy as neoadjuvant treatment. Neoadjuvant sintilimab plus concurrent chemoradiotherapy had an acceptable side-effect profile. All three patients underwent surgical gastrectomy after a median of 3.9 months. A major pathological response occurred in two resected tumors and a pathologic complete response was observed in one patient. Our results suggest that PD-1 blockade combined with chemoradiotherapy is a promising strategy as a neoadjuvant therapy in patients with unresectable locally advanced gastric cancer.
Assessment of the Quality of Life in Parents of Children With ADHD: Validation of the Multicultural Quality of Life Index in Norwegian Pediatric Mental Health Settings

Background: The brief generic Multicultural Quality of Life Index (MQLI) is a culturally informed self-report 10-item questionnaire used to measure health-related quality of life (QoL). QoL is an important outcome measure in guiding healthcare and is held as a substantial parameter to evaluate the effectiveness of healthcare. Attention Deficit Hyperactivity Disorder (ADHD) in children might negatively influence the parents’ QoL. Having a validated questionnaire to measure QoL for this population will therefore be a vital first step in guiding healthcare for parents of children with ADHD. We aimed to examine the reliability and validity of the Norwegian version of the MQLI in a sample of parents of children with ADHD. Methods: In a cross-sectional study, 128 parents of children with ADHD were recruited from four outpatient clinics within the Child and Adolescents Mental Health Services (CAMHS) in Norway. They completed the MQLI along with an alternative well-being scale, the Five-item World Health Organization Well-being Index (WHO-5), and a form including demographic variables. Reliability and validity of the MQLI were examined. We conducted a factor analysis and calculated internal consistency and the correlation between the MQLI and the WHO-5. Results: Factor analysis of the parents reported MQLI yielded a one-factor solution. For the MQLI, Cronbach’s alpha was 0.73. The correlation between the two measures of MQLI and WHO-5 was high (r = 0.84), reflecting convergent validity since the association between the two measures was strong. Conclusion: Results from this study support the reliability and validity of the Norwegian version of the MQLI for assessment of quality of life in parents of children with ADHD with good psychometric properties. Study findings support the use of the questionnaire in CAMHS.
Gating current noise produced by Brownian models of a voltage sensor

The activation of voltage-dependent ion channels is associated with the movement gating charges, that give rise to gating currents. Although gating currents originating from a single channel are too small to be detected, analysis of the fluctuations of macroscopic gating currents originating from a population of channels can make a good guess of their magnitude. The analysis of experimental gating current fluctuations, when interpreted in terms of a Markov model of channel activation, are in accordance with the presence of a main step along the activation pathway carrying 2.3-2.4 e0 of charge. To give a physical interpretation to these results and to relate them to the known atomic structure of the voltage sensor domain, we employed a Brownian model of voltage-dependent gating that we recently developed using structural information and applying the laws of electrodynamics. The model was capable to reproduce gating currents and gating current fluctuations essentially similar to those experimentally observed. The detailed study of this model output, also performed by making several simplifications aimed at understanding the basic dependencies of the gating current fluctuations, suggests that in real ion channels the voltage sensor does not move in a fully Markovian regimen due to the relatively low (<5 kT) energy barriers separating successive intermediate states. As a consequence, the simultaneous jump of multiple gating charges through the gating pore becomes frequent, and this occurrence is at the origin of the relatively high single-step charge detected by assuming Markovian behavior.
A critical review of filter bubbles and a comparison with selective exposure

Abstract The new high-choice media environment has raised concerns that users of social networking sites primarily select political information that supports their political opinions and avoid information that challenges them. This behaviour is reinforced by personalisation algorithms that create filter bubbles and both narrow the available content and exclude challenging information over time. These concerns have, however, been contested. This article challenges the underlying theoretical assumptions about filter bubbles, and compares filter bubbles to what we already know about selective exposure and human psychology. The article lists nine counterarguments to the filter bubble thesis. In short, I argue that the assumptions of filter bubbles contradict many of the previous findings of selective exposure research. More specifically, when discussing filter bubbles there is a risk of confusing two arguments: one strong – but also trivial – that is about technology (e.g., personalisation leads to different information), and one weak and speculative – but also the most interesting – that is about society (e.g., personalisation increases political polarisation in society).
Personalisation of Therapies in COVID-19 Associated Acute Respiratory Distress Syndrome, Using Electrical Impedance Tomography

Abstract Introduction Each patient suffering from severe coronavirus COVID-19-associated acute respiratory distress syndrome (ARDS), requiring mechanical ventilation, shows different lung mechanics and disease evolution. Therefore, lung protective strategies should be personalised for the individual patient. Case presentation A 64-year-old male patient was intubated ten days after the symptoms of COVID-19 infection presented. He was placed in the prone position for sixteen hours, resulting in a marked improvement in oxygenation. However, after being returned to the supine position, his SpO2 rapidly dropped from 98% to 91%, and electrical impedance tomography showed less ventilation at the dorsal region and a ventral shift of ventilation distribution. An incremental and decremental PEEP trial under electrical impedance tomography monitoring was carried out, confirming that the dependent lung regions were recruited with increased pressures and homogenous ventilation distribution could be provided with 14 cmH2O of PEEP. The optimal settings were reassessed next day after returning from the second session of the prone position. After four prone position-sessions in five days, oxygenation was stabilised and eventually the patient was discharged. Conclusions Patients with COVID-19 associated ARDS require individualised ventilation support depending on the stage of their disease. Daily PEEP trial monitored by electrical impedance tomography can provide important information to tailor the respiratory therapies.
Mortality Rate and Predictors Among Patients with COVID-19 Related Acute Respiratory Failure Requiring Mechanical Ventilation: a Retrospective Single Centre Study

Abstract Aim The objective of the study was to assess mortality rates in COVID-19 patients suffering from acute respiratory distress syndrome (ARDS) who also requiring mechanical ventilation. The predictors of mortality in this cohort were analysed, and the clinical characteristics recorded. Material and method A single centre retrospective study was conducted on all COVID-19 patients admitted to the intensive care unit of the Epicura Hospital Center, Province of Hainaut, Belgium, between March 1st and April 30th 2020. Results Forty-nine patients were included in the study of which thirty-four were male, and fifteen were female. The mean (SD) age was 68.8 (10.6) and 69.5 (12.6) for males and females, respectively. The median time to death after the onset of symptoms was eighteen days. The median time to death, after hospital admission was nine days. By the end of the thirty days follow-up, twenty-seven patients (55%) had died, and twenty–two (45%) had survived. Non-survivors, as compared to those who survived, were similar in gender, prescribed medications, COVID-19 symptoms, with similar laboratory test results. They were significantly older (p = 0.007), with a higher co-morbidity burden (p = 0.026) and underwent significantly less tra-cheostomy (p < 0.001). In multivariable logistic regression analysis, no parameter significantly predicted mortality. Conclusions This study reported a mortality rate of 55% in critically ill COVID-19 patients with ARDS who also required mechanical ventilation. The results corroborate previous findings that older and more comorbid patients represent the population at most risk of a poor outcome in this setting.