Miracle-dz/UniFAR-FTUs huggingface dataset:
Searches for additional Higgs bosons and for vector leptoquarks in ττ ﬁnal states in proton-proton collisions at √ s = 13 TeV

Three searches are presented for signatures of physics beyond the standard model (SM) in ττ ﬁnal states in proton-proton collisions at the LHC, using a data sample collected with the CMS detector at √ s = 13 TeV, corresponding to an integrated luminosity of 138 fb − 1 . Upper limits at 95% conﬁdence level (CL) are set on the products of the branching fraction for the decay into τ leptons and the cross sections for the production of a new boson φ , in addition to the H ( 125 ) boson, via gluon fusion (gg φ ) or in association with b quarks, ranging from O (10 pb) for a mass of 60 GeV to 0.3 fb for a mass of 3.5 TeV each. The data reveal two excesses for gg φ production with local p -values equivalent to about three standard deviations at m φ = 0.1 and 1.2 TeV. In a search for t -channel exchange of a vector leptoquark U 1 , 95% CL upper limits are set on the dimensionless U 1 leptoquark coupling to quarks and τ leptons ranging from 1 for a mass of 1 TeV to 6 for a mass of 5 TeV, depending on the scenario. In the inter-pretations of the M 125h and M 125h,EFT minimal supersymmetric SM benchmark scenarios, additional Higgs bosons with masses below 350 GeV are excluded at 95% CL. Submitted to the Journal of High Energy Physics the SS selection of the DR. The resulting event yield and shapes of the m totT and m ττ distributions are compared to the OS selection of the DR. This test reveals a consistent result within the statistical uncertainties of the estimate, for events with N b-jets = 0. For events
LaneSNNs: Spiking Neural Networks for Lane Detection on the Loihi Neuromorphic Processor

Autonomous Driving (AD) related features represent important elements for the next generation of mobile robots and autonomous vehicles focused on increasingly intelligent, autonomous, and interconnected systems. The applications involving the use of these features must provide, by definition, real-time decisions, and this property is key to avoid catastrophic accidents. Moreover, all the decision processes must require low power consumption, to increase the lifetime and autonomy of battery-driven systems. These challenges can be addressed through efficient implementations of Spiking Neural Networks (SNNs) on Neuromorphic Chips and the use of event-based cameras instead of traditional frame-based cameras. In this paper, we present a new SNN-based approach, called LaneSNN, for detecting the lanes marked on the streets using the event-based camera input. We develop four novel SNN models characterized by low complexity and fast response, and train them using an offline supervised learning rule. Afterward, we implement and map the learned SNNs models onto the Intel Loihi Neuromorphic Research Chip. For the loss function, we develop a novel method based on the linear composition of Weighted binary Cross Entropy (WCE) and Mean Squared Error (MSE) measures. Our experimental results show a maximum Intersection over Union (IoU) measure of about 0.62 and very low power consumption of about 1 W. The best IoU is achieved with an SNN implementation that occupies only 36 neurocores on the Loihi processor while providing a low latency of less than 8 ms to recognize an image, thereby enabling real-time performance. The IoU measures provided by our networks are comparable with the state-of-the-art, but at a much low power consumption of 1 W.
Development of a Quality Metrics Definition, Evaluation and Quantification Framework for EUD Web Components

—Web components technology improves Internet applications development. Although still at the experimental stage, there is a growing interest in its quality metrics. We aim to define a reference and evaluation framework for measuring the quality of web components and mashups. This paper presents the pilot phase of a real experimentation environment for comparing reference metrics built from existing software quality metrics with curated metrics based on user-perceived quality. The preliminary results of the evaluation of the alpha version conducted by the developers who participated in platform design and development speak for the suitability of the selected approach.
Asset Prices and Eﬃciency in a Krebs Economy

: © 2014 Elsevier Inc. I study the asset pricing implications and the efficiency of a tractable dynamic stochastic general equilibrium model with heterogeneous agents and incomplete markets along the lines of Krebs (2003a). Contrary to previous applications of these types of models, I find that generically the distribution of idiosyncratic shocks affects the risk premia of aggregate shocks and that the equilibrium is constrained inefficient in the sense that a planner can Pareto improve the equilibrium outcome by assigning different portfolio choices to agents. The inefficiency is caused by a 'portfolio externality': the average portfolio of the economy affects the portfolio return of each Abstract I study the asset pricing implications and the eﬃciency of a tractable dynamic stochastic general equilibrium model with heterogeneous agents and incomplete markets along the lines of Krebs (2003a). Contrary to previous applications of these types of models, I ﬁnd that generically the distribution of idiosyncratic shocks aﬀects the risk premia of aggregate shocks and that the equilibrium is constrained ineﬃcient in the sense that a planner can Pareto improve the equilibrium outcome by assigning diﬀer-ent portfolio choices to agents. The ineﬃciency is caused by a ‘portfolio externality’: the average portfolio of the economy aﬀects the portfolio return of each agent. The constrained eﬃcient outcome can be achieved through linear taxes and subsidies that I characterize in closed-form.
The C. elegans dosage compensation complex propagates along chromatin dynamically and independently of X-chromosome sequence

SUMMARY The C. elegans Dosage Compensation Complex (DCC) associates with both X chromosomes of XX animals to reduce X-linked transcript levels. Five DCC members are homologous to subunits of the evolutionarily conserved condensin complex, while two non-condensin subunits are required for DCC recruitment to X. Here, we investigated the molecular mechanism of DCC recruitment and spreading along X by examining gene expression and the binding patterns of DCC subunits in different stages of development, and in strains harboring X;autosome fusions. We show that DCC binding is dynamically specified according to gene activity during development, and that the mechanism of DCC spreading is independent of X-chromosome DNA sequence. Accordingly, in X;A fusion strains DCC spreading propagates from X-linked recruitment sites onto autosomal promoters as a function of distance. Quantitative analysis of spreading suggests that the condensin-like subunits spread from recruitment sites to promoters more readily than subunits involved in initial X-targeting. Via these mechanisms, a highly conserved chromatin complex is appropriated to accomplish domain-scale transcriptional regulation during development. Similarities to the X-recognition and spreading strategies used by the Drosophila DCC suggest mechanisms fundamental to chromosome-scale gene regulation.
Virological Synapse-Mediated Spread of Human Immunodeﬁciency Virus Type 1 between T Cells Is Sensitive to Entry Inhibition (cid:1) †

Human immunodeﬁciency virus type 1 (HIV-1) can disseminate between CD4 (cid:1) T cells via diffusion-limited cell-free viral spread or by directed cell-cell transfer using virally induced structures termed virological synapses. Although T-cell virological synapses have been well characterized, it is unclear whether this mode of viral spread is susceptible to inhibition by neutralizing antibodies and entry inhibitors. We show here that both cell-cell and cell-free viral spread are equivalently sensitive to entry inhibition. Fluorescence imaging analysis measuring virological synapse lifetimes and inhibitor time-of-addition studies implied that inhibitors can access preformed virological synapses and interfere with HIV-1 cell-cell infection. This concept was supported by electron tomography that revealed the T-cell virological synapse to be a relatively permeable structure. Virological synapse-mediated HIV-1 spread is thus efﬁcient but is not an immune or entry inhibitor evasion mechanism, a result that is encouraging for vaccine and drug design.
An Evaluative Study of Impact of Dividend Policy Exhibiting on Stock Prices of Auto-sector Firms of Pakistan (2006-2015).

:-The study was carried out to examine the effect of firm dividend policies on their respective stock prices. Ten years (2006-2015) panel data was collected from fourteen selected firms of the sector on the basis of the availability of data. Random Effect Model of Regression was used to check the link between the one dependent Market Price and five independent variables i.e. Dividend Yield, Retention Ratio, Profit after Tax, Earnings per Share and Return on Equity. To check various anomalies in data tests were applied. This study found significantly negative relationship of Dividend Yield and Retention Ratio with Market price but significant and positive affiliation of Profit after Tax and Earning per Share with Market Price. But no evidence found the impact of Return on Equity with Market Price. This study found mixed results about chief determinants like dividend yield and retention ratio. Reciprocally did not match each other to support Dividend Relevance theory. On the basis of results this study recommended to the management to develop best policy by considering shareholders wealth and growth of companies.
THE EFFECT OF SITAGLIPTIN AND MIRABEGRON ON SERUM LEPTIN, ADIPONECTIN, TUMOR NECROSIS FACTOR-α AND OXIDATIVE STRESS IN STREPTOZOTOCIN-INDUCED DIABETIC RATS

Adiponectin increases insulin increase ABSTRACT Introduction: Mirabegron is a novel beta-3 receptor agonist. It has potential antiobesity and antidiabetic effects. The aim of the study was the evaluation of the possible antidiabetic, anti-inflammatory and antioxidant effects of mirabegron as well as its effect on serum leptin and adiponectin in diabetic rats alone and in combination with sitagliptin. Materials and Methods : Five groups of Wistar rats were used. Diabetes was induced in group 2, 3, 4 and 5 using streptozotocin in dose of 100 mg/kg. The third, fourth and fifth group were treated for 20 days with sitagliptin (10 mg/kg), mirabegron (10 mg/kg) and combination of the 2 drugs, respectively. Blood samples were used for determination of blood glucose, serum level of leptin, adiponectin, TNF-α, malondialdehyde (MDA) and glutathione (GSH). Results: Streptozotocin caused induction of type-2 diabetes, increased TNF-α and MDA with reduction in the leptin, adiponectin and GSH. Sitagliptin caused a significant reduction of blood glucose, TNF-α and MDA with significant increase in leptin, adiponectin and GSH. Mirabegron caused a non-significant reduction of blood glucose, TNF-α and MDA with significant increase in the leptin and GSH. There was non-significant difference between the effect of the combination of sitagliptin and mirabegron and the effect of sitagliptin alone. Conclusion: Sitagliptin has a moderate anti-inflammatory and antioxidant effects. Mirabegron has a modest antidiabetic, anti-inflammatory and antioxidant effects and failed to normalize the low serum levels of leptin and adiponectin of streptozotocin induced diabetic rats. The addition of mirabegron to sitagliptin shows no additional or synergistic effects.
A newly developed dispersal capacity metric indicates succession of benthic invertebrates in restored rivers

Dispersal capacity plays a fundamental role in riverine benthic invertebrates’ colonization of new habitats that emerge following flash floods or restoration. However, an appropriate measure of dispersal capacity for benthic invertebrates is still lacking. Dispersal of benthic invertebrates occurs mainly during the aquatic (larvae) and aerial (adult) life stages, and each can be further subdivided into active and passive modes. Based on these totally four dispersal modes, we firstly developed a simple metric to estimate dispersal capacity for 528 benthic invertebrate taxa by incorporating weight for each mode. Secondly we tested this metric using benthic invertebrate community data from a) 23 restored river sites all involving an improvement of river bottom habitats dating back 1 to 10 years, b) 23 unrestored sites, and c) 298 adjacent surrounding sites in the low mountain and lowland areas of Germany. We hypothesize that our metric will reflect the temporal succession process of benthic invertebrate communities colonizing the restored sites, while no temporal changes are expected in the unrestored and surrounding sites. By applying our metric to these three river treatment categories, we found that the average dispersal capacity of benthic invertebrate communities in the restored sites decreased significantly within the early years following restoration, while there were no changes in both unrestored and surrounding sites. After dividing all taxa into quartiles representing weak to strong dispersers, this pattern became even more obvious; strong dispersers colonized the restored sites during the first year after restoration and then significantly decreased over time, while weak dispersers continuously increased. The successful application of our metric to river restoration might be promising to further apply this metric for example in river assessments or meta-community structure. significant trends. Four dispersal groups defined by a quartile approach are: weak dispersers = 0–25 th ; weak-medium dispersers = 25 th −50 th ; strong-medium dispersers = 50 th −75 th ; and strong dispersers = 75 th −1.
AWARENESS AND PRACTICE OF HEALTH PROMOTION FOR WOMEN IN CALABAR,

Aim: A descriptive survey was undertaken to ascertain nurses’ awareness and level of practice of health promotion among women in Calabar. Background: Women’s health is affected by array of factors; nurses could have a major impact in increasing women’s capacity to exercise increased control over their lives and determinants of health. Method: One hundred and thirty six nurses drawn from the ante-natal clinics of primary, secondary and tertiary health facilities in Calabar participated in the study. A questionnaire with a content validity index of 0.91 was used for data collection. The test-retest reliability coefficient of the questionnaire was (r) 0.79. Ethical issues were addressed. Data were analyzed with statistical package for social sciences (SPSS) version 15. Findings: Majority 110 (80.9%) of the participants were highly experienced, 96 (70.6%) were managers while only 52 (38.2%) had 1st degree and above. Health education was the most mentioned strategy of health promotion by participants 136 (100.0%) while specific protection was the least mentioned 3(2.2%). Only about half of the respondents 68 (50.0%) practiced health promotion appropriately. Nurses’ rank and years of working experience were significantly associated with appropriate practice. Conclusion: Nurses averagely practice health promotion. It was therefore recommended that Nurse Managers should provide learning opportunities to fill observe gaps in knowledge and motivate junior nurses to engage in women’s health promotion at every opportunity.
RESEARCH ARTICLE Social Support and Quality of Life in Turkish Patients with Gynecologic Cancer

The aim of this study was to determine the level of social support and quality of life in Turkish patients with gynecologic cancer using a cross-sectional survey design. A total of 108 patients admitted to the gynecologic oncology clinic at a university hospital from September 2011 to January 2012 were included. Data were collected using patient information forms, the Multidimensional Scale of Perceived Social Support (MSPSS) and The Quality of Life-Cancer Survivors Instrument (QOL-CS). Average age was 54.5±10.8 years and it was determined that 65.7% of patients had ovarian cancer and 19.4% had cervical cancer. The total QOL-CS mean score was 5.59±1.10. Average score of total MSPSS was found to be 69.7±14.64. Comparing socio-demographic and clinical characteristics of patients and average scores of QOL-CS and MSPSS, it was found that there was not a statisticaly significant corelation (p>0.05). Statistically significant relation was found between the average scores of QOL-CS and MSPSS. These results showed that quality of life was moderate and perceived social support was high in Turkish patients with gynecologic cancer. and to This study is to determine and to investigate relationship between
Identiﬁcation of the Entamoeba histolytica Galactose-Inhibitable Lectin Epitopes Recognized by Human Immunoglobulin A Antibodies following Cure of Amebic Liver Abscess

Immunity to Entamoeba species intestinal infection is associated with the presence of intestinal IgA antibodies against the parasite’s galactose-inhibitable adherence lectin. We determined the epitope speciﬁcity of serum and intestinal antilectin IgA antibodies by enzyme-linked immunosorbent assay using overlapping fragments of a recombinant portion of the lectin heavy subunit, designated LC3. These ﬁndings were correlated with the effects of epitope-speciﬁc murine antilectin immunoglobulin A (IgA) monoclonal antibodies (MAbs) on amebic in vitro galactose-speciﬁc adherence. LC3 is a highly antigenic and immunogenic cysteine-rich protein (amino acids [aa] 758 to 1150) that includes the lectin’s carbohydrate binding domain. The study subjects, from Durban, South Africa, were recently cured of amebic liver abscess (ALA) with or without concurrent Entamoeba histolytica intestinal infection or were infection free 1 year after cure. We also studied seropositive subjects that were infected with E. histolytica , disease free, and asymptomatic. Serum anti-LC3 IgA antibodies from all study groups exclusively recognized the third (aa 868 to 944) and the seventh (aa 1114 to 1134) LC3 epitopes regardless of clinical status; epitope 6 (aa 1070 to 1114) was also recognized by serum anti-LC3 IgG antibodies. However, IgG antibody recognition of epitope 6 but not 3 or 7 was lost 1 year following cure of ALA. We produced 14 murine anti-LC3 IgA MAbs which collectively recognized ﬁve of the seven LC3 epitopes. The majority of the murine MAbs recognized the ﬁrst epitope (aa 758 to 826), which was not recognized by human IgA antibodies. Interestingly, adherence of E. histolytica trophozoites to CHO cells was inhibited by MAbs against epitopes 1, 3, 4 (aa 944 to 987), and 6 ( P < 0.01). The LC3 epitopes recognized by human IgA antibodies (3 and 7) were further characterized by use of overlapping synthetic peptides. We identiﬁed four peptides (aa 891 to 903, 918 to 936, 1114 to 1134, and 1128 to 1150) that in linear or cyclized form were recognized by pooled intestinal IgA antibodies and serum IgG antibodies from subjects with ALA and asymptomatic, seropositive infected subjects. This study identiﬁes the lectin epitopes to be studied in an amebiasis subunit vaccine designed to elicit mucosal immunity mimicking that of humans cured of ALA.
Photodynamic Therapy in Conjunction with 5-Aminolevulinic Acid 5% Impact of Efficacy in Management of Acne Vulgaris

Background: Pathological basis for acne vulgaris is multifactorial in origin that involves integration of various factors involving inflammation in conjunction with raised sebum productivity levels causing pilosebaceous unit obstruction becoming a suitable media for propionebacterium acnes, Particular wave lengths used in photodynamic therapy in conjunction to photosensitizers applied to affected skin have revolutionized the management course of acne vulgaris disease particularly severe forms Aim: Assessing the effectiveness and toleration at clinical levels of 5% aminolevulinic acid gel as a thermosetting agent in conjunction with photo dynamic therapy red-light in the management of mild to moderate forms of acne vulgaris disease. Methodology: The research study is a prospective fashioned study conducted in Al-Azhar university Hospitals between October 2018 and January 2019. Results: GAG score before, at end of treatment, at last follow up was statistically significant p values=0.001, whereas percentage of improvement at end of treatment and at last follow up were not statistically significant p value=0.378, 0.617, consecutively. Conclusion: Photodynamic therapy mode in conjunction of the photosensitizing agent aminolaevulinic acid 5% is a promising management mode for moderate to severe forms of acne vulgaris however future research studies are required to be multicentric in fashion with larger sample sizes to verify the research study results with consideration of racial and ethnic differences as a factor that could affect the responsiveness rate of treatment. photo dynamic therapy red-light in the management of mild to moderate forms of acne vulgaris disease.
CORROSIVE INTAKE AND ESOPHAGEAL STRICTURE FORMATION: A CASE STUDY

: This study is aimed to quantify the effects of ingestion of corrosives that lead to the injuries of esophagus and formation of strictures. Method: This is retrospective cross-sectional study, conducted on 188 patients having history of corrosive ingestion that have lead to esophageal injuries. The patients underwent upper GI endoscopy during first 48 hours of the incident, and same procedure was repeated 6 weeks after the incident to check for stricture formation. Result: In the data collected, 99 patients were found to have severe esophageal injuries following the incident of corrosive intake; conversly, 89 patients found to have mild injuries. Among the severely injured 99 patients 31 were reported to have developed the strictures due to corrosive ingestion in comparison to the 10 cases who have mildly injured esophagus resulted in strictures. The difference was significant statistically. Conclusion: In the light of our study, it is concluded that the patients who get lethal esophageal injuries more tend to develop strictures in comparison with the patients with mild esophageal injury.
The Arabidopsis Malectin-Like Leucine-Rich Repeat Receptor-Like Kinase IOS1 Associates with the Pattern Recognition Receptors FLS2 and EFR and Is Critical for Priming of Pattern-Triggered Immunity

a,5 Plasma membrane-localized pattern recognition receptors such as FLAGELLIN SENSING2 (FLS2) and EF-TU RECEPTOR (EFR) recognize microbe-associated molecular patterns (MAMPs) to activate the ﬁ rst layer of plant immunity termed pattern-triggered immunity (PTI). A reverse genetics approach with genes responsive to the priming agent b -aminobutyric acid (BABA) revealed IMPAIRED OOMYCETE SUSCEPTIBILITY1 (IOS1) as a critical PTI player. Arabidopsis thaliana ios1 mutants were hypersusceptible to Pseudomonas syringae bacteria. Accordingly, ios1 mutants demonstrated defective PTI responses, notably delayed upregulation of PTI marker genes, lower callose deposition, and mitogen-activated protein kinase activities upon bacterial infection or MAMP treatment. Moreover, Arabidopsis lines overexpressing IOS1 were more resistant to P. syringae and demonstrated a primed PTI response. In vitro pull-down, bimolecular ﬂ uorescence complementation, coimmunoprecipitation, and mass spectrometry analyses supported the existence of complexes between the membrane-localized IOS1 and FLS2 and EFR. IOS1 also associated with BRASSINOSTEROID INSENSITIVE1-ASSOCIATED KINASE1 (BAK1) in a ligand-independent manner and positively regulated FLS2/BAK1 complex formation upon MAMP treatment. Finally, ios1 mutants were defective in BABA-induced resistance and priming. This work reveals IOS1 as a regulatory protein of FLS2- and EFR-mediated signaling that primes PTI activation upon bacterial elicitation.