Miracle-dz/UniFAR-FTUs huggingface dataset:
12- vs. >12-Month dual Antiplatelet therapy after Drug-eluting stent implantation: A meta-analysis

The American College of Cardiology and American Heart Association(ACC/AHA) guidelines recommend that dual-antiplatelet therapy(DAPT) be administered for at least 12 months after drugeluting stent(DES) implantation [1], while the European Society of Cardiology and European Association for Cardio-Thoracic Surgery(ESC/EACTS) recommend 6-12 months [2]. Therefore, the optimal duration of dual antiplatelet therapy (DAPT) with aspirin and a P2Y12 inhibitor after drug-eluting stent implantation remains a matter of debate. What would be the safest and shortest DAPA duration after DES implantation?
Thyroid dysfunction in patients treated with the immune checkpoint inhibitor nivolumab: different clinical features

Rationale. Immune Checkpoint Inhibitors (ICIs) are approved for some advanced neoplasms, increasing survival. ICIs block inhibitor receptors cytotoxic T lymphocyte antigen 4 (CTLA4) and programmed death-1 (PD-1) and trigger T cell-mediated immunity against tumor. Their action is accompanied by several immunity-related adverse events (IRAEs), also involving the endocrine system (pituitary, thyroid, adrenals). We report two different cases of thyrotoxicosis following administration of the anti-PD-1 nivolumab. Patients. Patient 1, M, 75 years-old, treated for non-small cell lung carcinoma (NSCLC) since September 2016, with euthyroid multinodular goiter. In January 2017 (12 weeks from baseline), he developed frank hyperthyroidism, with positive TSH-receptor antibodies (TRAb) and thyroperoxidase antibodies (TPOAb). A Tc99m thyroid scintiscan showed diffuse uptake and “cold” areas. After nivolumab withdrawal, treatment with metimazole (MMI) 5 mg per day was started and euthyroidism was resumed, so to restart the drug in May 2017. Patient 2, M, 80 years-old, treated for a left-eye choroid melanoma since January 2017, with euthyroid nodular goiter. In April 2017 (6 weeks from baseline), thyrotoxicosis was detected, with positive thyroglobulin antibodies (Tg-Ab, 244 IU/ml, nv 4.5 µIU/ml (subclinical hypothyroidism). Patient was treated with replacement doses of levothyroxine (LT-4), and continued nivolumab infusions. Conclusions. Two forms of thyrotoxicosis were reported: the first with thyroid hyperfunction and positive TRAb, the latter as a destructive thyroiditis. In both cases (mean onset after 9 weeks), the moderate severity and the appropriate management of endocrine IRAEs allowed treatment continuation.
Optimal Group Size for High School Students' Collaborative Argumentation Using SNS for Educational Purposes

This study aims to identify the optimal group size for High School Students' Collaborative Argumentation using SNS for educational purposes. The study is based on the participation of high school students; the participants were divided under two experimental conditions. The students were required to engage in one of two types of arguments: argumentation via SNS or face-to-face argumentation. Furthermore, the students were divided into small groups comprising three to five participants for each condition. Conversations and task performances were collected as the students were engaged in discussions. The transition probabilities between two talkers in the group, the number of utterances, and the task performances were analyzed. The results showed that the 3-person group discussed in a lively manner; however, it was difficult to obtain the consensus of this group. The 4-person group did not converse much initially but eventually conversed enough to be compared with other groups. It was also easy to obtain the group’s consensus. The 5-person group conversed less, possibly due to social loafing. The findings suggest that a 4-person group is the optimal size for collaborative argumentation using SNS for educational purposes.
Predictive Significance of IL-17A Serum Levels during Chemotherapy in Senegalese Women with Cervical Cancer

Background and Objectives: Cervical cancer is a leading cause of cancer death in female populations. It is a virally induced carcinoma resulting from sexually transmitted high risk Human Papillomavirus infections (e.g. HPV-16, HPV-18). Previous studies have shown associations between IL-17A levels in cancer micro-environments and metastasis of tumor cells. In Africa, chemotherapy (CT) is the standard first-line treatment for cervical cancer and the prognosis remains poor for metastatic and recurrent cases. The impact of CT as a treatment option is still unclear. We investigated the prognostic relevance of IL-17A profiles in Cervical cancer patients (CP) patients treated with cisplatin in combination with 5-fluouracil (5FU) for three cycles. Methods: The study included 57 CP and 59 women with no history of malignancy as healthy controls (HC). IL-17A plasma levels were evaluated by ELISA. For each CP, three blood samples were collected at three-week intervals before initiation of the chemotherapy protocol. Results: Before chemotherapy CP showed higher serum levels of IL-17A compared to HCs (p = 0.035). No relation was detected between age and IL-17A levels. We observed a significant increase in serum IL-17A during treatment of the CP group (p < 0.05). Depending on chemotherapy’s efficacy, CP were divided into 1) non responders, 2) partial responders and 3) good responders. Non-responders patients showed significantly higher serum levels of IL-17A during the follow-up compared to partial and good responder groups both following the first CT cycle (p < 0.05) and the second CT cycle (p < 0.03). Conclusion: Our results suggest that high serum levels of IL-17A are associated with poor responses to classical chemotherapy. However, considering these results to design CC biomarkers, we need further investigations particularly about the relevant prognostic indicator following chemotherapy.
Wine research and its relationship with wine production: a scientometric analysis of global trends

Background and Aims The economic value of wine has increased over the years due to the emergence of new producers and new markets. In line with this, the global distribution of research outputs in viticulture and oenology has also shifted since this informs wine production and consumption. This study investigates the trends in wine and grape publications indexed in Web of Science (2002–2017). Methods and Results Using bibliometric techniques, citation impact, research specialisation and collaboration network were analysed. China had the largest annual growth in wine‐related publications, Spain had the largest total number of wine‐related publications and the USA had the highest citation impact. Australia was the sixth in terms of publication share and fifth in terms of citation share. European countries collaborate mostly with one another and Portuguese and Spanish speaking countries form another collaboration cluster. Wine and grape science is a diverse field with food science and technology scholars being the main contributors and funding coming mostly from governments agencies. Conclusions Scientific collaboration in the field does not closely follow the grouping of countries into Old and New World wine producers. While the amount of published wine research was strongly correlated with wine production for Old World countries, there was no correlation for New World countries. Significance of the Study This study improves the search strategy for retrieving wine and grape research from scholarly databases. It also provides an up‐to‐date account of global wine research trends.
Standardization of the Persian Version of the Academic Commitment Scale

Background Academic commitment as a new specialized issue has attracted the attention of educational researchers. Despite of the conducting relevant studies, it was more considered by Human-Vogel and Rabe. Their designed research tool has not yet been used in Iran. Objectives The purpose of this study was to investigate the factor structure and reliability of this tool in Iranian learners. Methods The primary tool consisted of 30 items and 5 dimensions (students’ satisfaction with their studies, level of commitment, investment, quality of alternatives, and meaningfulness). In this cross-sectional study, 449 pre-university students of Bandar Abbas city were selected through multi-stage sampling. Data were analyzed using AMOS and SPSS software. Confirmatory factor analysis was used to examine factor structure. Cronbach’s alpha coefficient and Gottman and Spearman-Brown split-half coefficients, were used to test the reliability. Results After examination the validity of the tool, five items were excluded and finally a questionnaire including 25 questions was obtained. Beta coefficients were greater than 0.4. Model fit indices, including root mean square error of approximation (RMSEA), Comparative fit index (CFI), goodness of fit index (GFI), adjusted goodness of fit index (AGFI), normed fit index (NFI), incremental fit index (IFI), and Tucker-Lewis index (TLI) were obtained 0.04, 0.95, 0.91, 0.90, 0.90, 0.95, and 0.94, respectively, indicating the fitness of this five-factor tool. A Cronbach’s alpha coefficient of 0.87, a Gottman’s split-half of 0.65, and a Spearman-Brown split-half of 0.68 were obtained, indicating the appropriate reliability of the instrument. Conclusions Based on the results, the final version of the tool seems to be suitable for assessing academic commitment in Iranian learners in the Iran educational systems.
Intra and Inter-Rater Reliability for Deep Neck Flexor and Neck Extensor Muscle Endurance Tests in Subjects with and without Subclinical Neck Pain

Abstract Purpose Deep neck flexor (DNF) and neck extensor (NE) muscle endurance tests are a part of standard assessment procedure in routine physical therapy practice and these tests needs to be reliable. Materials and Methods Intra-rater (between-day) and inter-rater (within-day) reliability was assessed for 2 neck muscle endurance tests in 26 subclinical neck pain and 31 normal subjects by 2 blinded assessors. The tests conducted included 1) DNF endurance test performed in supine and 2) NE muscle endurance test performed in prone position. Results and discussion The Intra-rater and inter-rater reliability was determined by means of Intra Class Correlation (ICC), with 95% confidence intervals. The intra rater reliability testing showed good agreement for both DNF (ICC=0.76 and 0.78) and NE muscle endurance (ICC=0.75 and 0.76) tests. Meanwhile, the inter-rater reliability showed moderate to good agreement for both DNF (ICC – 0.58 and 0.61) and NE muscle endurance tests (ICC – 0.57 and 0.74) in subjects with subclinical neck pain. Subclinical neck pain subjects had a significantly lower endurance holding times compared to normal (p<0.001). Conclusion The intra and inter rater reliability ranged from moderate to good agreement. Neck flexor and extensor muscle endurance can be measured reliably in a clinical setup in subjects with subclinical neck pain.
Executive Function Strategies used by Children and Adolescents with Fetal Alcohol Spectrum Disorder

The outcomes associated with prenatal alcohol exposure (PAE) are profound, affecting many aspects of cognitive, behavioural, and social development that can be seen in the day-to-day health and functioning of affected individuals. Executive dysfunction has been identified as a particular area of weakness for children with Fetal Alcohol Spectrum Disorder (FASD). Researchers using various neuropsychological tests suggest that children with FASD underperform on many executive functioning tasks; however, they do not tell us which strategies children with FASD are capable of using to aid executive function performance. Observational data was collected on the strategies used by seven children with FASD as they completed cognitively demanding computer games as part of a larger executive function intervention study. Results revealed that children and adolescents used any number of 25 different strategies to aid their executive functioning performance. Furthermore, they were able to increase the number of strategies they used spontaneously and decrease the number of strategies used through prompting over the course of the intervention. Overall, older participants used more spontaneous strategies and significantly fewer prompted strategies than younger children. These results suggest that children and adolescents with FASD can use a wide and varied battery of executive function strategies that if transferred outside of the intervention setting, could have a potentially positive effect on their daily functioning. Acknowledgements First, I would like to thank my supervisor, Dr. Jacquie Pei for giving me the opportunity to pursue this work. Jacquie, I appreciate that you encouraged me to think critically and independently and that you have prepared me so well for thinking about real world implications for research. As I move forward in my education, I will always view you as my mentor. I would also like to thank Dr. Lia Daniels for her support and assistance on this project and for giving me the opportunity to continue my education under her guidance. Thanks also to Dr. Marie-Claire Shanahanmy defense was a very positive experience and I have my committee to thank for a wonderfully thoughtprovoking conversation about my research. I would like to recognize my parents, Jan and Carl Hutchison, and the rest of my family for your toleration and unwavering support of my academic pursuits. To my friends, thank you not only for listening to me talk about my research but for your advice, empathy, and hugs along the way. Finally, I owe endless appreciation to Jay Makela for your humour, love, and encouragement during times of stress and late nights. You and Louie have helped me to make this experience very memorable. Table of
Diagnostic value of echocardiographic indices and cardiac biomarkers in dogs with chronic mitral valve insufficiency

Because all dogs having heart diseases are not in symptomatic heart failure stage, it is important to determine the stage of heart failure in dogs with heart diseases. Therefore, this study evaluated the diagnostic value of several echocardiographic parameters and cardiac biomarkers for differentiating dogs with heart disease from healthy dogs and dogs with symptomatic heart failure from dogs with asymptomatic heart failure. The study population consisted of 51 dogs having chronic mitral valvular insufficiency (CMVI) with varying degrees of heart failure and 18 healthy control dogs. Several echocardiographic parameters and cardiac biomarkers were evaluated to achieve the study aims. The study found that there were significant differences in indexed left atrial diameter (iLA), left atrial to aorta ratio (LA/Ao), left ventricular diastolic dimension to aorta ratio (LVIDd/Ao), transmitral E-peak (E-peak), septal E/Ea ratio (sE/Ea), parietal E/Ea ratio (pE/Ea) and N-terminal probrain natriuretic peptide (NT-proBNP) between the control dogs and the CMVI dogs (P 11.9 mm, LA:Ao >1.32, LVIDd/Ao >1.91, E-peak >80 cm/sec, sE/Ea >7.0, pE/Ea >6.9, and NT-proBNP >980 pmol/L, while the cut-off values for indicating heart failure were iLA >12.7 mm, LA:Ao >1.58, LVIDd/Ao >2.08, E-peak >90 cm/sec, sE/Ea >9.0, pE/Ea >8.9, and NT-proBNP >1200 pmol/L. This study found that iLA, LA/Ao, E-peak, E/Ea and NT-proBNP were the most reliable and consistent markers for detecting heart disease and differentiating symptomatic heart failure dogs from asymptomatic dogs with CMVI.
Hubungan Pelatihan Keterampilan Dengan Pengetahuan Kader Tentang Peran Fungsi Sistem 5 Meja Di Posyandu Wilayah Kerja Puskesmas Jatinangor Kabupaten Sumedang

Pos Pelayanan Terpadu atau Posyandu yaitu sarana yang memudahkan masyarakat dalam mendapatkan pelayanan kesehatan. Dalam penyelenggaraan posyandu yang memiliki peran penting salah satunya adalah kader. Kader memiliki peran dan fungsi dalam kegiatan Posyandu salah satunya yaitu menjadi pelaksana sistem 5 meja di Posyandu, namun pada kenyataannya sistem 5 meja belum berjalan secara optimal hal tersebut dapat dipengaruhi oleh beberapa faktor salah satunya pengetahuan. Tujuan dari penelitian ini yaitu untuk mengetahui hubungan frekuensi pelatihan yang di ikuti dengan pengetahuan kader tentang peran dan fungsinya di posyandu terutama pada sistem 5 meja. Metode : Penelitian ini adalah analitik dengan pendekatan cross-sectional. Sampel dalam penelitian ini adalah kader di wilayah keja Puskesmas Jatinangor. Pengambilan sampel menggunakan Teknik Propotionate Stratified random samplingdengan jumlah sampel 83 responden. Analisis data menggunakan uji Gamma. Penelitian menunjukan bawha terdapat hubungan yang signifikan antara frekuensi pelatihan dengan tingkat pengetahuan (p = 0.000). Terdapat hubungan antara frekuensi pelatihan yang pernah diikuti dengan pengetahua kader tentang peran fungsi sistem 5 meja di Posyandu wilayah kerja Puskesmas jatinangor kabupaten Sumedang.
Pushed or Pulled Out? The Racialization of School Choice in Black and White Mothers’ (Home) Schooling Decisions for Their Children

Homeschooling is an increasingly common schooling option for middle-class black families yet is often overlooked in research on race and education. Drawing on interviews with 67 middle-class black and white mothers living in one northeastern metropolitan area—half of whom homeschool, while the other half enroll their children in conventional school—the author examines how race influences mothers’ decisions to homeschool or conventional school. The findings show that mothers’ schooling explanations reflect their experiences as shaped by the racial hierarchy constituted in schools. Black mothers respond to a push out of conventional schools on the basis of their children’s experiences of racial discrimination. In contrast, white mothers respond to a pull out of conventional schools to individualize their children’s academic programs. Building on racialized organizations and critical race theory, these findings elucidate how the formal structure of schools is racialized in ways that constrain black mothers’ agency, while enabling the agency of white mothers to activate school choice. The findings underscore how homeschooling, often assumed to be race neutral, is racialized in ways that reproduce inequalities under school choice and appears to redress discrimination in schools.
Driving a Wedge? Republicans, Immigration, and the Impact of Substantive Appeals on African American Vote Choice

Recently, a number of prominent Republican elites have argued that the economic plight of African Americans is attributable to undocumented immigration to the United States. Have these arguments concerning the link between black economic well-being and undocumented immigration become commonplace in the rhetoric of Republican elites, and if so, does exposure to these appeals impact black vote choice? Employing data from over forty years of congressional speeches, the campaign speeches and public addresses of President Donald Trump, televised campaign advertisements from the Wisconsin/Wesleyan Advertising Projects, and a survey experiment embedded in the 2016 Cooperative Congressional Election Study, we find that Republican elected officials have increasingly made substantive appeals to blacks on the issue of immigration reform, that exposure to this type of substantive appeal leads blacks to more strongly support a fictional Republican candidate, and that this support is moderated by a respondent’s level of linked fate. These findings challenge existing scholarship that Republican elites ignore the concerns of the black community and suggest that Republicans may be using the issue of immigration to drive a wedge in the Democratic electoral coalition by targeting the Democratic Party’s strongest constituency.
Electrical effects in winding of large electrical ac machines application to advanced large size DFIM

In the context of global warming, renewable energies will play a more and more important and global role. The main drawback of "classical" renewable energies, namely Wind and Solar energy, lies in their unpredictability. The electrical grid needs high energy storage to ensure its stable operation. Today’s most powerful energy storage is hydro pump storage. To meet the electrical grid’s demand on pump power variation, GE Renewable Energy develops since 10 years variable speed machines (also called Doubly Fed Induction Generators or DFIG). Within turbogenerators, the phenomenon of circulating currents in Roebel bars is well known, while is it has not yet been studied for DFIGs. The main goal of this study is to calculate the circulating currents in the stator and rotor bars of DFIG under different operating points with a theoretical and practical precision of around 1%. This study starts with an overview of the current situation in circulating current calculation and presentation of the characteristic circulating current curves for a hydrogenerator, study that led to a patent application. After a presentation of the possible calculation methods and models based on a deep and broad literature review, this study performs with a deep review of the slot inductance model analysing its precision and limitations. Based on these finds, two novel analytical models are proposed to enhance the taking into account of the strand dimensions. Only the last slot inductance model developed, based on a slot differential inductance model, permits to take the strand dimensions and the saturation into account. This model is validated experimentally using a small-scale slot/strand-model, while all slots models are compared to each other to highlight their differences. The winding overhang model and novel analytical expressions are presented in a later chapter as well as the analytical treatment of the rotor overhang made of non-linear steel. The winding overhang model uses analytical expressions to determine the magnetic field and vector potential in the winding overhang, which have the advantage of additional knowledge compared to the results of a finite-element computation. In another chapter, novel exact transient current and torques expressions are derived for a DFIG experiencing a 3-phase and a 2-phase short-circuit. Then the winding overhang force computation and the circulating current calculation results are presented in two crowing chapters. In these chapters, the influence of the approximation and boundary on the end winding forces as well as the origin of the end winding forces are shown. The last result chapter