Miracle-dz/UniFAR-FTUs huggingface dataset:
COVID-19 in Iran: the Good, the Bad, and the Ugly Strategies for Preparedness – A Report From the Field

ABSTRACT The emergence of coronavirus disease 2019 (COVID-19), a novel unknown virus that is challenging whole countries all over the world, has prompted different strategies from various governments. Iran, as one of the first countries to experience the onset of the virus outbreak, made and implemented some policies that should be assessed, so that lessons may be learned for the future. Although some negative actions and policies, such as delays in cancellation of international flights especially from China, not taking the disease seriously and comparing it with seasonal influenza, and the like, are hard to ignore, some impressive actions are also vividly clear. Policies, such as social distancing, dramatically increasing social awareness about preventive actions in terms of public health, and using masks and hand washing, were cost-effective policies that resulted in successful control of the virus in the first onset. While some quite clearly ineffective decisions were made by Iranian authorities, the huge catastrophic effect of sanctions cannot be forgotten. Possibly in level situations with similar countries, Iran will have far better results regarding preparedness for future pandemics like COVID-19.
Influence of immediate predation risk by lions on the vigilance of prey of different body size

The effects on vigilance behavior of environmental cues that affect perceived risk of predation have been widely measured in gregarious herbivores. How extrinsic (e.g., predator activity within certain habitats) and intrinsic (e.g., within-group competition) cues interact depends on the biology of the prey species. However, very little is known about the impact of the actual presence of the predator in the vicinity on fine scale prey vigilance behavior. For this study, we monitored the vigilance of plains zebra (Equus quagga) and impala (Aepyceros melampus) in and around Hwange National Park, Zimbabwe. We assessed how the presence of radio-collared lions (Panthera leo) affected the vigilance of their prey. To evaluate the factors affecting vigilance behavior, we measured routine and intense vigilance. Routine vigilance can be conducted while chewing, although during intense vigilance chewing is halted and thus imposes foraging costs as food processing is delayed. As the most acute form of vigilance, we predicted that the presence of lions would lead to an increase in intense vigilance in both species. We found this to be the case for zebra, a key prey species for lions, while impala adjusted their intense vigilance to risk cues less specific to the presence of lions. Potential predation risk posed by lions in the immediate vicinity differs not only between species but also for a given species in different contexts. Our results also reveal how other environmental risk indicators influence the structure of vigilance behavior of large prey species in a manner that reflects their respective ecologies.
Foodweb analysis of the Orinoco floodplain based on production estimates and stable isotope data

Stable isotope data and indirect methods for estimating consumer production were used in a foodweb analysis for the Orinoco River floodplain, Venezuela. The ratio of annual production to mean annual biomass (Pa/B̄) was estimated from mass at maturity for all major categories of consumers. Field data on B̄ then were used to estimate Pa for each major category. Carbon sources for all categories of consumers were identified through δ13C analysis, and trophic shifts in δ15N were used in assigning trophic levels to consumers. The ultimate C source for both invertebrates and fish was algae (phytoplankton and periphyton), even though macrophytes and litterfall from the floodplain forest composed 98% of potentially available C. Production of invertebrate consumers (benthos, rhizofauna, and zooplankton), which occurred almost entirely through 1st-level consumption, was estimated as 14 g C m−2 y−1. Fish, which produced 11 g C m−2 y−1, showed a mean δ15N trophic shift of 1.8 units above the algal C source, suggesting that ∼20% of fish production was directly accountable to consumption of algal C (1st-level consumption), and that most of the remainder was attributable to 1st-level carnivory. Data on production and trophic shifts implied trophic efficiency of 5% for invertebrates and 20% for fish. Although the food web is focused on a very small fraction of potentially available primary C (algae), this C source can account quantitatively for the observed production of both invertebrates and fish. The food web showed marked trophic compression (large consumers supported by trophic levels 1 and 2), which is the only means by which high production of large consumers can be sustained on a small fraction of the potentially available C.
Three new araphid diatoms (Bacillariophyta) from the Maritime Antarctic Region

A revision of taxa from the genus Staurosira and Staurosirella from the Maritime Antarctic Region, formerly identified as Staurosirella ( Fragilaria ) pinnata and Fragilaria alpestris , resulted in the description of three new taxa: Staurosira pottiezii Van de Vijver sp. nov., Staurosirella antarctica Van de Vijver & E.Morales sp. nov. and S. frigida Van de Vijver & E.Morales sp. nov. Detailed light (LM) and scanning electron microscope (SEM) observations are used to better characterize the morphology and ultrastructure of these three new taxa. Comparisons with similar taxa and the ecological preferences of each species are added. The revision of these species confirmed the endemic nature of the Antarctic diatom flora.
Risk Stratification for 2-Year Mortality in Patients with Chronic Limb-Threatening Ischemia Undergoing Endovascular Therapy

Aim: The latest Global Vascular Guidelines (GVG) recommend assessing the 2-year mortality risk in patients with chronic limb-threatening ischemia (CLTI) before revascularization. This study aimed to reveal whether the Wound, Ischemia and foot Infection (WIfI) classification, developed originally as a risk assessment tool for limb prognosis, would be useful in predicting the 2-year mortality risk in patients with CLTI in the era of GVG and WIfI. Methods: We retrospectively analyzed 849 patients with CLTI who were primarily treated with endovascular therapy (EVT) between April 2010 and December 2016. The impact of baseline characteristics, including the WIfI classification on mortality risk, was investigated using the Cox proportional hazards regression model. Results: During a mean follow-up of 19.3 months, 243 deaths were observed. The 2-year mortality rate was 32.3%. Multivariate analysis demonstrated that WIfI classification stages ( p =0.037), in addition to male sex ( p =0.010), age ( p ＜0.001), non-ambulatory status ( p ＜0.001), body mass index ( p =0.002), and hemodialysis ( p ＜0.001), were independent predictors for an increased risk of mortality, while the Rutherford classification was not. Conclusions: WIfI classification stages were independently associated with mortality risk in patients with CLTI undergoing EVT, while the Rutherford classification was not. The WIfI classification would be a practical tool for planning the revascularization strategy in CLTI treatment.
Biological Effect of gamma irradiations on in vitro culture of Stevia rebaudiana

Current investigation was carried out to study effects of gamma irradiations on in vitro culture of S. rebaudiana. The dosages used were 5, 10, 15, 20, 25 and 30 kR (Kiloradians). Explants were selected from plants, derived from gamma irradiated seeds were subjected for callus induction, callus proliferation and somatic embryogenesis on the MS medium fortified with 2.5 mg/l 2,4-D. Differences in the morphology and growth rate of callus were recorded. High dose of Gamma irradiation showed necrosis of explants. The somatic embryogenesis percent decreased with increasing dosage of gamma radiations. Somatic embryo generation was significantly affected by higher doses of gamma rays. This study also indicates that plants produced from seeds irradiated with 5 - 10 kR gamma rays influences callus induction and growth. Explants obtained from plants, grown from gamma irradiated seeds with higher doses such as 25 kR and 30 kR delays callus induction. The data on Days to callus induction, growth rate and somatic embryogenesis, indicate that low dose of gamma radiation is effective for the production of variability in Stevia plants.
Embedding “Smart” Disease Coding Within Routine Electronic Medical Record Workflow: Prospective Single-Arm Trial

Background Electronic medical record (EMR) chronic disease measurement can help direct primary care prevention and treatment strategies and plan health services resource management. Incomplete data and poor consistency of coded disease values within EMR problem lists are widespread issues that limit primary and secondary uses of these data. These issues were shared by the McMaster University Sentinel and Information Collaboration (MUSIC), a primary care practice-based research network (PBRN) located in Hamilton, Ontario, Canada. Objective We sought to develop and evaluate the effectiveness of new EMR interface tools aimed at improving the quantity and the consistency of disease codes recorded within the disease registry across the MUSIC PBRN. Methods We used a single-arm prospective trial design with preintervention and postintervention data analysis to assess the effect of the intervention on disease recording volume and quality. The MUSIC network holds data on over 75,080 patients, 37,212 currently rostered. There were 4 MUSIC network clinician champions involved in gap analysis of the disease coding process and in the iterative design of new interface tools. We leveraged terminology standards and factored EMR workflow and usability into a new interface solution that aimed to optimize code selection volume and quality while minimizing physician time burden. The intervention was integrated as part of usual clinical workflow during routine billing activities. Results After implementation of the new interface (June 25, 2017), we assessed the disease registry codes at 3 and 6 months (intervention period) to compare their volume and quality to preintervention levels (baseline period). A total of 17,496 International Classification of Diseases, 9th Revision (ICD9) code values were recorded in the disease registry during the 11.5-year (2006 to mid-2017) baseline period. A large gain in disease recording occurred in the intervention period (8516/17,496, 48.67% over baseline), resulting in a total of 26,774 codes. The coding rate increased by a factor of 11.2, averaging 1419 codes per month over the baseline average rate of 127 codes per month. The proportion of preferred ICD9 codes increased by 17.03% in the intervention period (11,007/17,496, 62.91% vs 7417/9278, 79.94%; χ21=819.4; P<.001). A total of 45.03% (4178/9278) of disease codes were entered by way of the new screen prompt tools, with significant increases between quarters (Jul-Sep: 2507/6140, 40.83% vs Oct-Dec: 1671/3148, 53.08%; χ21=126.2; P<.001). Conclusions The introduction of clinician co-designed, workflow-embedded disease coding tools is a very effective solution to the issues of poor disease coding and quality in EMRs. The substantial effectiveness in a routine care environment demonstrates usability, and the intervention detail described here should be generalizable to any setting. Significant improvements in problem list coding within primary care EMRs can be realized with minimal disruption to routine clinical workflow.
Minimally Invasive Percutaneous Nephrolithotomy with a Novel Vacuum-assisted Access Sheath for obstructive calculous pyonephrosis ：A Randomized Study.

PURPOSE To investigate the safety and efficacy of Minimally Invasive Percutaneous Nephrolithotomy (MPCNL) combined with Vacuum-assisted Access Sheath in the treatment of obstructive calculous pyonephrosis. MATERIALS AND METHODS Seventy-six patients with obstructive calculous pyonephrosis, who were planned to receive MPCNL, were randomly divided into two groups. Group A was treated with Amplatz sheath combined with Cyberwand double probe ultrasound lithotripsy, and group B was treated with Vacuum-assisted Access Sheath (VAAS, ClearPetra, Well lead Medical) combined with holmium laser lithotripsy. The primary outcome was the operation successful rate. Other perioperative, and postoperative data such as operation time, stone free rate and complications were compared between groups. RESULTS Single 20F access sheath was established in all cases. All patients underwent one-stage procedure. Compared with group A, group B had a higher initial stone-free rate (84.2% vs 63.1%, P= .037). The operation time of group B was 56.3 ± 19.83 min, significantly shorter than that of group A at 70.4 ± 14.83 min. The complication rate of B group was 15.8%, which was lower than that of group A (P= .035 ). Five patients (15.8 %) of group B had a postoperative fever (>38.5 ºC) (Clavien grade 2) that required additional antibiotics; whereas 8 patients (21.1 %) of group A (P= .361). There was no blood transfusion in group A, and one case in group B required transfusion. CONCLUSION One-stage MPCNL combined with Vacuum-assisted Access Sheath and holmium laser lithotripsy is a simple, safe, effective, and ergonomically practical method for selected patients with obstructive calculous pyonephrosis.
The psychological consequences of (perceived) ionizing radiation exposure: a review on its role in radiation-induced cognitive dysfunction

Abstract Purpose Exposure to ionizing radiation following environmental contamination (e.g., the Chernobyl and Fukushima nuclear accidents), radiotherapy and diagnostics, occupational roles and space travel has been identified as a possible risk-factor for cognitive dysfunction. The deleterious effects of high doses (≥1.0 Gy) on cognitive functioning are fairly well-understood, while the consequences of low (≤0.1 Gy) and moderate doses (0.1–1.0 Gy) have been receiving more research interest over the past decade. In addition to any impact of actual exposure on cognitive functioning, the persistent psychological stress arising from perceived exposure, particularly following nuclear accidents, may itself impact cognitive functioning. In this review we offer a novel interdisciplinary stance on the cognitive impact of radiation exposure, considering psychological and epidemiological observations of different exposure scenarios such as atomic bombings, nuclear accidents, occupational and medical exposures while accounting for differences in dose, rate of exposure and exposure type. The purpose is to address the question that perceived radiation exposure - even where the actual absorbed dose is 0.0 Gy above background dose - can result in psychological stress, which could in turn lead to cognitive dysfunction. In addition, we highlight the interplay between the mechanisms of perceived exposure (i.e., stress) and actual exposure (i.e., radiation-induced cellular damage), in the generation of radiation-induced cognitive dysfunction. In all, we offer a comprehensive and objective review addressing the potential for cognitive defects in the context of low- and moderate-dose IR exposures. Conclusions Overall the evidence shows prenatal exposure to low and moderate doses to be detrimental to brain development and subsequent cognitive functioning, however the evidence for adolescent and adult low- and moderate-dose exposure remains uncertain. The persistent psychological stress following accidental exposure to low-doses in adulthood may pose a greater threat to our cognitive functioning. Indeed, the psychological implications for instructed cohorts (e.g., astronauts and radiotherapy patients) is less clear and warrants further investigation. Nonetheless, the psychosocial consequences of low- and moderate-dose exposure must be carefully considered when evaluating radiation effects on cognitive functioning, and to avoid unnecessary harm when planning public health response strategies.
microRNA‐related single‐nucleotide polymorphisms and breast cancer

Breast cancer, as the most common cancer in women which affects patients both mentally and physically, requires great attention in many areas and many levels as this cancer is known to be multifactorial. Single‐stranded molecules called microRNAs with near 22 nucleotides are seen to act in central dogma of molecular biology by inhibiting the translation process; it is demonstrated that any alteration in their sequence especially single‐nucleotide polymorphisms (SNPs) may lead into increasing the breast cancer risk. miR‐SNPs are considered to be the potential biomarkers for early detection of breast cancer. As a result, this review documents the well‐known miR‐SNPs that are known to be associated with breast cancer. In this regard, two principals were discussed: (a) SNPs in the target genes of microRNAs and the alteration in gene expression due to this phenomenon; (b) changes based on the SNPs in the microRNA coding region and the impact on their interaction with target messenger RNA.
Farm-Related Injuries and Fatalities Involving Children, Youth, and Young Workers during Manure Storage, Handling, and Transport

ABSTRACT Objective: Manure storage, handling, and transport facilities and equipment have been associated with life threatening hazards on many livestock farms. These hazards have been documented in prior research as including 1) exposure to toxic manure gases or lack of adequate oxygen in enclosed structures, which can be fatal to both humans and livestock; 2) below and above ground liquid manure storage structures that have the potential risk for drowning and falling; and 3) mechanical hazards associated with manure handling and transport equipment, including entanglement, road collisions, runover, and equipment failure. Methods: Over the past 40 years, Purdue University’s Agricultural Safety and Health Program (PUASHP) has collected, documented, and maintained data regarding agricultural-related injuries and fatalities associated with agricultural confined spaces in the United States. As part of ongoing surveillance, a total of 369 fatal and non-fatal cases relating to manure storage, handling and transport equipment, and facilities have been documented. Of these, 89 have involved children, youth, and young farm workers ages (birth–21) documented between 1975 and 2019. The purpose of this study was to summarize these 89 documented cases to better understand contributing factors and to develop recommendations for evidence-based strategies to reduce the frequency and severity of these incidents. Though recognized as not comprehensive for all incidents of this type, the data represent the largest data set known to exist, providing insight into previously unstudied hazards facing children and youth living and working on, and visiting farms as non-workers. Results: Findings in this study include: there has been an increase in the documented frequency of these incidents, which may be due, at least partially, to enhanced or more aggressive surveillance efforts; 57% of the cases were fatal; incidents involving underground or inground manure storage facilities were the most frequent type; incidents involving manure transport vehicles were higher than expected; 33% of the victims were five years of age and younger; and July was the month with the most documented incidents. Conclusions: Recommendations for future injury prevention strategies include incorporation of information on manure-related hazards in curricula targeting children and youth, more aggressive enforcement of child labor laws that currently prohibit the employment of youth to work in manure storage structures or to be involved in their operations, and greater use of physical and administrative controls, including safety signage, fencing, gates, and covers to restrict access to manure storage structures.
Shelf life of shrimp (Penaeus merguiensis) stored in ice (0°C) and partially frozen (—3°C)

Sensory, biochemical and microbiological changes and changes in SDS-PA GE patterns of myofibrillar and sarcoplasmic proteins were studied in shrimp (Penaeus merguiensis) muscle during storage at partial freezing temperature (—3°C; PFS) and in ice (0°C; IS). During PFS up to 20 days there were slight changes in biochemical parameters, apparently no changes in microbiological populations, and no changes in electrophoretic protein patterns. Rapid changes in these parameters occurred in IS over the same period. Sensory assessment of shrimps stored at PFS showed that a considerable increase in prime quality life was possible at this temperature over shrimps in IS. Prime quality life of shrimps in PFS was found to be 16 days, compared with 8 days in IS. Extension of prime quality life was attributed to the significantly slower rate of biochemical and microbiological changes at PFS compared with IS. Changes in sensory properties were associated with changes in some of the chemical properties.
Interleukin‐38 inhibits adipogenesis and inflammatory cytokine production in 3T3‐L1 preadipocytes

Interleukin‐38 (IL‐38) is a novel member of the IL‐1 cytokine family with anti‐inflammatory activity. However, its effect on adipogenesis and inflammatory cytokines secretion of adipocytes in vitro has not been reported. To address whether IL‐38 inhibits adipogenesis and inflammation in vitro, adipose precursor 3T3‐L1 cells were cultured with or without IL‐38. The morphology and size of lipid droplets in 3T3‐L1 cells were measured by Oil red O staining. The mRNA expression levels of GATA‐binding protein‐3 (GATA‐3), glucose transporter type 4 (GLUT4), peroxisome proliferator‐associated receptor γ2, IL‐1β, IL‐6, and monocyte chemoattractant protein‐1 (MCP‐1) in 3T3‐L1 cells were detected by real‐time PCR, The contents of IL‐6, IL‐1β, and MCP‐1 in 3T3‐L1 cell medium supernatants were determined by enzyme‐linked immunosorbent assay. IL‐38 significantly decreased the number of lipid droplets in 3T3‐L1 cells. IL‐38 also increased GATA‐3 and GLUT4 mRNA expression and inhibited IL‐1β, IL‐6, and MCP‐1 secretion by 3T3‐L1 cells. It is concluded that IL‐38 can inhibit the differentiation of human adipocytes and inflammatory cytokine production by 3T3‐L1 cells.