Miracle-dz/UniFAR-FTUs huggingface dataset:
The Current State of the Art in PARP Inhibitor-Based Delivery Nanosystems

Poly (adenosine diphosphate [ADP]–ribose) polymerases inhibitors (PARPi), the first clinically approved drug that exhibits synthetic lethality, are moving to the forefront of cancer treatments. Currently, the oral bioavailability of PARPi is quite low; thus, it is a major challenge to effectively and safely deliver PARPi during clinical cancer therapy. Nanotechnology has greatly advanced the development of drug delivery. Based on the basic characteristics and various forms of nanoparticles, drug delivery systems can prolong the time that drugs circulate, realize the controlled release of drugs, provide drugs with an active targeting ability, and spatiotemporally present combination treatment. Furthermore, nanosystems may not only enhance drug efficiency but also reduce adverse side effects. This review focuses on strategies involving nanoparticle-based delivery for PARPi, including single administration and codelivery with other agents. We believe that nanosystems have great potential in advancing PARPi efficacy for cancer therapy.
Smooth Invariant Manifolds and Normal Forms

Topological properties of flows and cascades in the vicinity of a rest point and a periodic trajectory finitely smooth normal forms of vector fields and diffeo-morphisms linear extensions of dynamical systems invariant subbundles of weakly non-linear extensions invariant manifolds normal forms in the vicinity of an invariant manifold.
Backscattering Effects on High-Speed Modulation of Strongly Injection-Locked Whistle-Geometry Semiconductor Ring Lasers

An injection-locking scheme, involving a single-frequency master laser monolithically integrated with a unidirectional whistle-geometry semiconductor microring laser, has been proposed for enhanced ultra-high-speed performance. Greatly enhanced high-speed modulation performance of the strong-injection-locking scheme has been predicted in numerical calculations. In our previous analysis, however, linear coupling between the two counter-propagating modes due to light backscattering was not taken into account. In this work, we investigate the potential negative impact of light backscattering between the two counter-propagating modes on high-speed modulation performance of strongly injection-locked unidirectional whistle-geometry semiconductor microring lasers.
Quantifying Narratives and Their Impact on Financial Markets

This article introduces a media coverage–based approach to quantify narratives and develops methodologies to explain the extent to which narratives drive financial markets and returns of investment portfolios. The authors show that media-derived narratives may contain predictive information for market returns beyond traditional macro indicators. Finally, the authors demonstrate that narrative indicators can be used to enhance asset-allocation strategies and to gain or hedge exposure to narratives by constructing portfolios of narrative-sensitive assets. These findings contribute to our understanding of how narratives influence financial markets and their impact on asset prices.
Double reptation vs. simple reptation in polymer melts (Erratum)

For polymer melts, the concept of "simple reptation" (or tube model) has been used by Doi and Edwards to calculate the stress relaxation function, but discrepancies have been found between the theoretical prediction and experimental data. By using ideas put forward by Rubinstein and Colby, it is shown here that the situation can be greatly improved by using the concept of "double reptation". This improvement is obtained without introducing additional parameters.
Intra-Articular Leukocyte-Rich Platelet-Rich Plasma versus Intra-Articular Hyaluronic Acid in the Treatment of Knee Osteoarthritis: A Meta-Analysis of 14 Randomized Controlled Trials

(1) Background: To evaluate the clinical effects of leukocyte-rich platelet-rich plasma (LR-PRP) and hyaluronic acid (HA) injections in treating patients suffering from knee osteoarthritis (OA); (2) Methods: Randomized controlled trials (RCTs) were searched from PubMed, Web of Science, and Cochrane Library. Keywords were: platelet-rich plasma, LR-PRP, leukocyte-rich, hyaluronic acid, and knee osteoarthritis. The included RCTs were published between the 1st of November 2011 and the 3rd of February 2021. Western Ontario and McMaster Universities Arthritis Index (WOMAC) scores, visual analog scale (VAS) scores, International Knee Documentation Committee (IKDC) scores, and adverse events were used as outcomes for evaluation; (3) Results: A total of 14 RCTs were enrolled. At 6 months, revealed that the LR-PRP group was better than the HA group in WOMAC total, pain, and physical function scores. At 12 months, the LR-PRP group was better than the HA group in WOMAC stiffness and physical function scores. There was no significant difference in adverse events; (4) Conclusion: LR-PRP injection showed no significant pain relief effect as compared with HA injection. However, LR-PRP demonstrated better overall outcomes as compared to HA in knee OA patients at the follow-up periods of 3, 6, and 12 months. LR-PRP injection may be recommended as a feasible option in treating patients with knee OA.
Dynamic Connectedness among Vaccine Companies’ Stock Prices: Before and after Vaccines Released

This study investigates the interconnectedness among the stocks of the publicly listed vaccine-producing companies before and after vaccine releases in 2020/21. In doing so, the study utilizes the daily frequency equity returns of the major vaccine producers, including Moderna, Pfizer, Johnson & Johnson, Sinopharm and AstraZeneca. First, the investigation applies the TVP-VAR Dynamic Connectedness approach to explore the time–frequency connectedness between the stocks of those vaccine producers. The empirical findings demonstrate that Moderna performs as the most prominent net volatility contributor, whereas Sinopharm is the highest net volatility receiver. Interestingly, the vaccine release significantly increases the stock market connectedness among our sampled vaccine companies. Second, the cross-quantile dependency framework allows for the observation of the interconnectedness under the bearish and bullish stock market conditions by splitting any paired variables into 19 quantiles when considering short-, medium- and long-memories. The results also show that a high level of connectivity among the vaccine producers exists under bullish stock market conditions. Notably, Moderna transmits significant volatility spillovers to Sinopharm, Johnson & Johnson and AstraZeneca under both the bearish and bullish conditions, though the volatility transmission from Moderna to Pfizer is less pronounced. The policy implication proposes that the vaccine release allows companies to increase their stock returns and induce substantial volatility spillovers from company to company.
Increasing Precision for Extended Reach 3D Manipulation

Object selection and manipulation in 3D immersive environments generally suffers from a lack of precision, primarily due to hand instability and tracking noise. Typically the lack of precision is exacerbated as the user begins to use techniques that allow distant interaction, such as Ray Casting, HOMER, and Go-Go. This problem can be addressed using velocity-based hand scaling such as PRISM, which has been applied to Ray Casting and HOMER previously. We present a study of the combination of Go-Go and PRISM. In our research, we have found that Go-Go + PRISM yields a nearly 2:1 improvement in precision over traditional Go-Go interaction when attempting to align two objects at a distance under time constraints
Supplier development and public procurement performance: Does contract management difficulty matter?

Abstract This paper investigates the relationship between supplier development and procurement performance in the public sector. Furthermore, the paper examines the moderating role of contract management difficulty on the relationship between supplier development and procurement performance. Using cross-sectional data collected from 179 public procuring entities, the main findings of the study are two-fold. Firstly, the relationship between supplier development and procurement performance in public sector is positive and significant (β = 0.2343 and p = 0.0014). Also, contract management difficulty negatively and significantly moderates the relationship between supplier development and procurement performance (β = −0.1447 and p = 0.0190). In this aspect, the influence of supplier development on procurement performance is negatively affected by contract management difficulties. The study contributes to the supplier management, procurement performance, and contract management literature by providing empirical evidence on the role of supplier development on procurement performance in developing countries like Tanzania. Also, the conditional effects of contract management difficulty on the relationship between supplier development and procurement performance matter. The study’s findings have important implications for procurement practitioners in the public sector and policy makers.
Are Elliptical Galaxies Really Metal-Rich?

We review estimates of the metallicities in elliptical galaxies, with an emphasis on recent results from the ASCA satellite. X-ray spectra of elliptical galaxies are adequately fit by models consisting of hot gas with subsolar Fe abundance and roughly solar Si-to-Fe ratio, plus a hard component from an ensemble of X-ray binaries. Although complications in the form of an extra soft continuum or multiple phases can be considered, we show that the consistency of the Si line diagnostic and continuum temperatures demonstrates that the data -- at the present level of sensitivity and spectral resolution -- do not require these. Optical and X-ray Fe abundance estimates are converging, although there are some cases with anomalously low X-ray values. Subsolar elliptical galaxy abundances require serious reconsideration of our preconceptions about elliptical galaxy chemical evolution, intracluster enrichment, and Type Ia supernova rates.
Vitamin D and Diseases of Mineral Homeostasis: A Cyp24a1 R396W Humanized Preclinical Model of Infantile Hypercalcemia Type 1

Infantile hypercalcemia type 1 (HCINF1), previously known as idiopathic infantile hypercalcemia, is caused by mutations in the 25-hydroxyvitamin D 24-hydroxylase gene, CYP24A1. The R396W loss-of-function mutation in CYP24A1 is the second most frequent mutated allele observed in affected HCINF1 patients. We have introduced the site-specific R396W mutation within the murine Cyp24a1 gene in knock-in mice to generate a humanized model of HCINF1. On the C57Bl6 inbred background, homozygous mutant mice exhibited high perinatal lethality with 17% survival past weaning. This was corrected by crossbreeding to the CD1 outbred background. Mutant animals had hypercalcemia in the first week of life, developed nephrolithiasis, and had a very high 25(OH)D3 to 24,25(OH)2D3 ratio which is a diagnostic hallmark of the HCINF1 condition. Expression of the mutant Cyp24a1 allele was highly elevated while Cyp27b1 expression was abrogated. Impaired bone fracture healing was detected in CD1-R396w/w mutant animals. The augmented lethality of the C57Bl6-R396W strain suggests an influence of distinct genetic backgrounds. Our data point to the utility of unique knock-in mice to probe the physiological ramifications of CYP24A1 variants in isolation from other biological and environmental factors.
Kinematic and kinetic analysis of transfemoral prosthesis

The feasibility of using transfemoral prosthesis Otto bock with 3R80 knee and articulated ankle1C30 “Trias” was analyzed from the perspective of dynamics and clinic. The kinematic and kinetic study of gait were performed on 5 amputated volunteers and 5 controls using videography techniques and force platform. Kinetic asymmetry gait is one of the main causes of hip joint degeneration. Combining kinematic and kinetic variables, we can draw important conclusions related to the dynamic imbalance of the main causes of hip degenerative diseases through the clinical trials of radiography film and density measurement, which has become an important tool to evaluate the feasibility of prosthetic design.
Bidding and Charging Scheduling Optimization for the Urban Electric Bus Operator

With the development of electric buses (EBs) in urban areas, how to effectively utilize their charging demand flexibility and the considerable energy stored in the on-board batteries becomes an urgent issue for the electric bus operator (EBO) to consider. This paper focuses on the bidding decision in energy and reserve markets for the urban EBO owning multiple electric bus stations with energy storage systems (ESSs), and the charging scheduling of all EBs. A trip-chain based electric vehicle boundary model is proposed firstly to concisely describe the flexibility region for an EB with multiple sequential trips, which can be further aggregated via a state-based approach to adapt to large-scale problems. The uncertain boundaries are also derived taking the uncertainty of trip energy consumption into account. In order to deal with the issue that the boundary aggregation will possibly influence the feasibility of decomposing the total power to each individual EB, the stochastic bidding and EB scheduling optimization problem in a hierarchical optimization framework is proposed. Accelerated Benders decomposition is utilized to efficiently solve the problem. Case studies verify that the proposed model can dramatically reduce the computational burden, effectively consider the uncertainty and take advantage of the flexibility of both EBs and ESSs to achieve better economic performance.
Sexual Behavior and Risky Practices among Adults Living with HIV/AIDS in Bayelsa State, Nigeria

Background: HIV/AIDS remains a public health challenge with an estimated 37.9 million persons living with HIV/AIDS (PLWHA) globally. Risky sexual behaviours/practices among PLWHA increase the likelihood of co-infection and further spread of infection. Understanding the pattern of these behaviours will aid in the modelling of campaigns to control further spread of infection. Aim: To examine sexual behaviour and risky practices among adults living with HIV in Bayelsa State, Nigeria. Methodology: Six hundred (600) participants were recruited for this cross-sectional study from the HIV/AIDS clinics at Federal Medical Centre (FMC), Yenagoa, and Otuasega Cottage Hospital, Ogbia in Bayelsa State, after obtaining informed consent. An interviewer-administered questionnaire was used to collect data comprising socio-demographic characteristics and the sexual activities/behaviour of the respondents in this study. The data obtained from the study were analyzed and presented as frequencies and percentages. Results: Most of the respondents reported sexual intercourse 532(88.7%) 3 months to study. Sexual intercourse with casual partners 20(3.8%), multiple sexual partners 72(12%), and sex workers 2(0.4%) were observed among the respondents. Regular use of condoms during sex was reported by 63(11.8%), while 200(37.6%) sometimes, 96(18.0%) rarely, and 173(32.5%) never. A recent treatment of sexually transmitted infections (STIs) was reported by 115(19.2%). Alcohol use before sex was reported by 218(36.3%). Overall, 253(42.2%) of the respondents engaged in at least one form of risky sexual behaviour. Conclusion: There is a preponderance of risky sexual behaviour/practices among PLWHA in Bayelsa State that may account for coinfection with STI as well as increase HIV/AIDS transmission.
Making sense of climate change: the case of Aotearoa New Zealand dairy farmers

ABSTRACT Climate change represents complexity for farmers in that events resulting from climatic changes can be concurrently abrupt, extreme, persistent, and can span boundaries. This can create complexity and difficulty for organisations in terms of how they make sense to act. To understand sensemaking processes, we explored climate change by studying a drought event. Relying on qualitative methods and a sample of dairy farmers in New Zealand who experienced a drought event over the decade 2003–2013, findings suggest that dairy farmers made sense by their: (1) embedded, immersive experience on farms; (2) use of ecological material; and (3) community interaction. Our findings extend insight into sensemaking processes, particularly in the areas of routine perspectives, the use of natural material objects, and the social nature of making sense. Implications are relevant to practitioners who work in farm associations, extension services and policy-making who have roles requiring them to communicate about climate change to farmers. We describe contributions, limitations, and opportunities for future research.
Basalt Fiber Composites with Reduced Thermal Expansion for Additive Manufacturing

Fused filament fabrication (FFF) is gaining attention as an efficient way to create parts and replacements on demand using thermoplastics. This technology requires the development of new materials with a reliable printability that satisfies the requirement of final parts. In this context, a series of composites based on acrylonitrile styrene acrylate (ASA) reinforced with basalt fiber (BF) are reported in this work. First, several surface modification treatments are applied onto the BF to increase their compatibility with the ASA matrix. Then, once the best treatment is identified, the mechanical properties, coefficient of thermal expansion (CTE) and warping distortion of the different specimens designed and prepared by FFF are studied. It was found that the silanized BF is appropriate for an adequate printing, obtaining composites with higher stiffness, tensile strength, low CTE and a significant reduction in part distortion. These composites are of potential interest in the design and manufacturing of final products by FFF, as they show much lower CTE values than pure ASA, which is essential to successfully fabricate large objects using this technique.
Mapping Forest Stability within Major Biomes Using Canopy Indices Derived from MODIS Time Series

Deforestation and forest degradation from human land use, including primary forest loss, are of growing concern. The conservation of old-growth and other forests with important environmental values is central to many international initiatives aimed at protecting biodiversity, mitigating climate change impacts, and supporting sustainable livelihoods. Current remote-sensing products largely focus on deforestation rather than forest degradation and are dependent on machine learning, calibrated with extensive field measurements. To help address this, we developed a novel approach for mapping forest ecosystem stability, defined in terms of constancy, which is a key characteristic of long-undisturbed (including primary) forests. Our approach categorizes forests into stability classes based on satellite-data time series related to plant water–carbon relationships. Specifically, we used long-term dynamics of the fraction of photosynthetically active radiation intercepted by the canopy (fPAR) and shortwave infrared water stress index (SIWSI) derived from the Moderate Resolution Imaging Spectroradiometer (MODIS) for the period 2003–2018. We calculated a set of variables from annual time series of fPAR and SIWSI for representative forest regions at opposite ends of Earth’s climatic and latitudinal gradients: boreal forests of Siberia (southern taiga, Russia) and tropical rainforests of the Amazon basin (Kayapó territory, Brazil). Independent validation drew upon high-resolution Landsat imagery and forest cover change data. The results indicate that the proposed approach is accurate and applicable across forest biomes and, thereby, provides a timely and transferrable method to aid in the identification and conservation of stable forests. Information on the location of less stable forests is equally relevant for ecological restoration, reforestation, and proforestation activities.
Interpreted History Of Neutrino Theory Of Light And Its Future

De Broglie's original idea that a photon is composed of a neutrino-antineutrino pair bound by some interaction was severely modified by Jordan. Although Jordan addressed an important problem (photon statistics) that de Broglie had not considered, his modifications may have been detrimental to the development of a composite photon theory. His obsession with obtaining Bose statistics for the composite photon made it easy for Pryce to prove his theory untenable. Pryce also indicated that forming transversely-polarized photons from neutrino-antineutrino pairs was impossible, but others have shown that this is not a problem. Following Pryce, Berezinskii has proven that any composite photon theory (using fermions) is impossible if one accepts five assumptions. Thus, any successful composite theory must show which of Berezinskii's assumptions is not valid. A method of forming composite particles based on Fermi and Yang's model will be discussed. Such composite particles have properties similar to conventional photons. However, unlike the situation with conventional photon theory, Lorentz invariance can be satisfied without the need for gauge invariance or introducing non-physical photons.
Antenna Array Topologies for mmWave Massive MIMO Systems: Spectral Efficiency Analysis

This article investigates the achievable spectral efficiency (SE) of millimeter wave massive multiple-input multiple-output systems with three different array topologies deployed at the base station (BS), namely uniform rectangular array (URA), uniform linear array (ULA) or uniform circular array (UCA). To be practical, both small scale fading and large scale path loss, and shadowing effects are considered in the analysis. A 3D channel model taking both the azimuth and elevation domains into account is adopted for the analysis of the URA and UCA topologies. Considering randomly distributed users in the cell, we firstly deduce the distribution functions of the distances between the users and the BS, and the azimuth and elevation angles of departure, respectively. Based on the derived probability distribution, tight approximations on the achievable SE with maximum ration transmission under the three antenna array topologies are derived. Analytical results show that under all the three topologies, the total achievable SE increases with the number of BS antennas, but decreases with the radius of cell and decay exponent. Moreover, it converges to a saturated value in the high SNR regime and a large inter-element spacing. It is also found that the UCA configuration has a superior achievable SE than the URA and ULA cases, and thus is the best choice for mmWave massive MIMO systems in terms of the achievable SE.