Miracle-dz/UniFAR-FTUs huggingface dataset:
MgATPase Activity May be Dispensable for the Openingof Mitochondrial Katp Channel by Diazoxide

It is generally accepted that activation of mKATP channels by diazoxide and others KATP channels openers (KCOs), similarly to sKATP channels, require MgATPase activity of the receptor SUR subunit, and the presence of MgATP as the prerequisite for the channel activation. However, literary data obtained on isolated mitochondria were controversial in this regard and numerous studies showed activation of mitochondrial K+ uptake by KCOs in the absence of MgATP. Recently we have shown high sensitivity of ATPsensitive K+ transport of rat liver mitochondria to DZ in the absence of MgATP. Considering that KATP channels of different cell types may exhibit different sensitivity to DZ, the purpose of this work was to examine possible tissue specificity of this phenomenon and compare the effect of DZ on ATP-sensitive K+ transport in brain and liver mitochondria in the absence and the presence of MgATP. On isolated mitochondria, we have found that full activation of K+ transport of both liver and brain mitochondria occurred at < 0.5 μM of DZ. MgATP shifted the sensitivity of K+ transport to DZ to micromolar concentration scale. Without MgATP, activation of ATPsensitive K+ transport was verified by the blockage with MgATP, glibenclamide, and 5-hydroxydecanoate, which allowed for its attribution to mKATP channels activity. Based on the experiments, we hypothesized that MgATP may be dispensable for the activation of native mKATP channel by DZ, and that mKATP channels might comprise high affinity sites for DZ binding in the absence of Mg∙ATP. Obtained results reveal novel aspects of mKATP channels activation by DZ.
The in vivo hepato-recovery effects of the polyphenol-rich fermented food Xeniji™ on ethanol-induced liver damage

Xeniji is a health food product produced by bacterial lactic acid fermentation. Although fermented foods, including Xeniji, have been widely consumed for various health purposes, including as an antioxidant to improve liver disease, their polyphenol content and in vivo hepato-recovery effects have yet to be evaluated. This study aims to evaluate the polyphenol content of Xeniji and its in vivo hepato-recovery effect on ethanol-induced liver damage. In this study, the polyphenolic acids of Xeniji are quantified by liquid chromatography-mass spectrometry (LCMS). In addition, the recovery effect of Xeniji on ethanol-induced liver damage in mice is evaluated by assessing the serum liver enzyme profile, liver inflammation, liver oxidative stress, and the level of CYP2E1. Xeniji is recorded to contain a high concentration of caffeoylquinic acid and sakuranetin, based on the LCMS-MS quantification results. In terms of the in vivo hepato-recovery study, intake of ethanol induces substantial liver damage indicated by an increase of the serum liver enzyme profile, liver inflammation, liver oxidative stress and the level of CYP2E1. On the other hand, Xeniji promotes recovery from ethanol-induced liver damage by restoring antioxidant levels, enhancing the metabolism of ethanol in the liver and suppressing inflammation in a dosage-dependent manner. Xeniji is a fermented functional food that possesses hepato-recovery effects on ethanol-induced liver damage.
Effectiveness of red propolis and Mikania glomerata in bitches´s surgical analgesia

The aim of this research was to evaluate the analgesia provided by red propolis and Mikania glomerata oral administration in 40 female dogs submitted to ovariohysterectomy (OH) compared to standard treatment with no steroidal anti-inflammatory ketoprofen. Through of a doble-blind and randomized study, the animals were divided in four different groups with 10 animals of treatments: control treatment with ketofen (CT), propolis treatment (PT), Mikania glomerata treatment (MT), and propolis-Mikania glomerata treatment (PGT). All pacients received one of these treatments two hours before OH and the pain evaluation was performed 1 (T1), 6 (T6), 12 (T12), and 24 hours (T24) after OH using University of Melbourne Pain Scale and the Glasgow Composite Measure Pain Scale. Glucose levels were also measured at the same times, except at 6 hours after OH (T6). All treatments achieved similar and satisfactory analgesia. During the experiment, only three animals were rescued, two belonging to the PT and another of the MT. Considering the lower rate of complications and no rescue necessity of in PGT and CT treatments, they were considered the most effective and safer. The combined treatment with propolis and Mikania glomerata could be a promising alternative method for OH surgery analgesia in bitches.
IMMEDIATE VERSUS DELAYED LOADING FOR DENTAL IMPLANTS SUPPORTING MANDIBULAR OVER-DENTURES IN TYPE II DIABETIC PATIENTS

The aim of this study is to evaluate the effect of immediate loading on dental implants supporting mandibular complete overdenture in controlled type II diabetic patients both clinically and radiographically. Fourteen completely edentulous males; controlled type II diabetic patients were selected for the study. Their HbA1c (Glycosylated Hemoglobin) level was around 7. All were examined with pre-operative CBCT (cone-beam computed tomography) to evaluate the future implant site, and for proper selection of implant size. First implant was installed in one side of the inter-foraminal region of the mandible, then after 4 months the second implant was installed in the other side. Two weeks later both implants were loaded by incorporation of O-ring attachments into the existing mandibular complete denture as a direct clinical procedure in the mouth. Both radiographic evaluation of crestal bone loss using CBCT, and clinical evaluation of implant stability using resonance frequency analysis (Osstell device) were made at time of loading, 3, 6, 12 and 24 months after loading. The results showed that after 24 months of loading no significant difference observed between the immediate and delayed loading protocols either clinically (Implant stability), or radiographically (Crestal bone loss). The only significant difference observed in the implant stability between both groups was at time of loading. In this study all clinical and radiographic results suggested that dental implants could be used as a successful and predictable treatment to retain mandibular complete overdentures in controlled type II diabetic patients with a very high success rate either immediately or delayed loaded.
Psychological distress impact and associated factors among Jordanian women diagnosed with breast cancer

Background: Patients with breast cancer often experience an extremely high psychological distress. Psychological distress includes both depression and anxiety as a specific framework. Existing study in these psychological symptoms (either anxiety or depression) were more strongly associated with the level of pain that is unavailable in breast cancer patients. This research aims to compare the levels of depression and anxiety among patients with different levels of psychological distress. The association between changes in distress at baseline and time of admissions with depression and anxiety was examined. Methods: This is a cross-sectional descriptive study. The study included two hundred female people who are suffering from breast cancer. They were tested using the Hospital Anxiety and Depression Scale (HADS) at the time of diagnosis -Baseline and during admission. The data were collected on age, ethnicity, types of treatment and cancer staging. Results: There is no significant difference of mean anxiety between intervention and control group at baseline (P = 0.361) and admission time (P = 0.385) but various age groups showed a statistically significant difference on their corresponding mean perceived anxiety (P=0.028) with having previous medical insurance (P = 0.050). Also there is no significant difference of mean depression in baseline and admission time. Aged women experience less depression, although there is no significant difference. Women without previous medical insurance have higher level of depression compare with others (P = 0.003). Conclusion: Anxiety and depression are a type of severe psychiatric condition that has attributed to the feelings of apprehension in breast cancer. Finding from this study would support screening for anxiety and depression, early diagnosis, and counselling to improve the psychological well-being of patients with breast cancer. Further research would be required to assess the therapeutic interventions' efficacy.
CONTROLLED-RELEASE FERTILIZER AFFECTS GROWTH AND YIELD OF JAPONICA RICE

Resin-blending controlled-release fertilizer (RBB) is more consistent with the nutrient requirement of rice; the appropriate application rate though was unclear. To optimize the application rate of RBB for japonica rice in Tai-Lake region (11954E, 3117N), China, the effects of different application rate of first time used to given in full on grain yield. When conducted in 2015 and 2016, four application rates of RBB, i) conventional application rate (RBB1, 270 kg·ha), ii) reduction by 10% (RBB2, 243 kg·ha), iii) reduction by 20% (RBB3, 216 kg·ha), and iv) reduction by 30% (RBB4, 189 kg·ha); and the control, split application of conventional fertilizers (CN, 270 kg·ha), were employed. The results showed that compared with the CN treatment, a 10-30% reduction of RBB enhanced the grain yield with the yield of RBB1 treatment (9.23 t·ha) was the highest in 2015, when RBB3 (9.72 t·ha) was the highest in 2016, due to higher panicle number. The larger panicle numbers and the high LAI and photosynthetic potential after anthesis were the main reasons for the higher yield. The results indicated that the application rate of RBB could be reduced to 189-216 kg·ha without affecting the grain yield.
Phenotype-specific store-operated calcium entry and the differentiation response in neuroblastoma cells

Understanding the fundamental molecular mechanisms that control the proliferationdifferentiation cellular switch and maintenance of the differentiated state is needed to fully harness the therapeutic potential for highly detrimental diseases such as cancer and neurodegenerative disorders. Intracellular free Ca plays an essential role in the differentiation process and, more specifically, the ubiquitous Ca signalling pathway; storeoperated Ca entry (SOCE) is altered with differentiation. The SH-SY5Y neuroblastoma cancer cell line was utilised in this study to investigate the role of SOCE in phenotype-specific differentiation responses using morphological, biochemical and functional single cell, Ca imaging techniques. Neuroblastoma is a paediatric malignancy of the sympathetic nervous system that is comprised of immature neural crest cells. Retinoic acid is used to treat neuroblastoma patients however many respond poorly, leading to aggressive disease progression. The SHSY5Y neuroblastoma-derived cell line consists of three morphologically distinct phenotypes; immature neuroblastic N-type cells, non-neuronal S-type cells and putative intermediate Itype cells, which exhibit variable tumourgenicity and can be induced to differentiate using 9cis-retinoic acid (9cRA). The 9cRA-induced differentiation response of N-type and S-type populations involved morphological changes accompanied by an uncoupling of SOCE from Ca store release that could be observed from the first day of 9cRA treatment. SOCE down-regulation was attributed to changes in expression and localisation of the CRAC channel protein Orai1 and the Ca sensing protein STIM1. The extent of SOCE uncoupling was influenced in N-type and I-type cells but not S-type cells by the predominant background cell environment. Conditioned media from proliferating and differentiating N-type and S-type populations was also able to influence cell phenotype and the associated SOCE responses. This study describes how the 9cRA-induced differentiation response occurred in a multi-step manner in N-type populations and in gradual manner in S-type populations and raises the possibility that SOCE proteins could potentially be utilised as drug targets in neuroblastoma treatment or neurodegenerative disease therapy.
Lactobacillus acidophilus reduces Listeria monocytogenes infection by inhibiting mitogen-activated protein kinase genes in growing rabbits

ABSTRACT We aimed to investigate the effect of Lactobacillus acidophilus ACCC11073 on the growth performance, oxidation, inflammation, and mitogen-activated protein kinase (MAPK) family genes of rabbits infected with Listeria monocytogenes (L. monocytogenes) using antibiotic enrofloxacin hydrochloride (EH) as a reference. There were four treatments including negative control, positive control with L. monocytogenes infection on the first day of feeding trial (PC), PC + EH at 40 mg kg−1, and PC + L. acidophilus at 108 CFU kg−1 of diet using [. ]
How do consumers use signals to assess wine quality ?

In this article, we analyse the way some 6,000 Euro pean wine consumers use, according to their type (connoisseurs versus n on-connoisseurs), a set of available signals (price, regional umbrella, goodwi ll, past consumption) to assess the quality of Bordeaux wines. From the empirical analysis, we learn that (i) Pric e -not the umbrella “Bordeaux”is the main signal used by both types o f consumers, (ii) Price is a substitute for umbrella for non-connoisseurs who se em to use it all the more that their knowledge of the umbrella Bordeaux is quite l imited. Our results suggest that : (i) connoisseurs are awa re that Bordeaux as an umbrella is not a relevant quality signal or that i t fa ls to reveal a too heterogenous level of quality, (ii) non connoisseurs have a limi ted knowledge of the umbrella Bordeaux to be able to use it more frequently to in fer quality. This paper, by pointing out the weakness of the Umb rella Bordeaux helps to understand why Bordeaux wines tend nowadays to lose market shares in favour of more easily recognizable wines produced by new-worl d winegrowers whose strategy is based on a more efficient and simpler c ommunication (brand plus type of grape).
Impact of Characteristics of Board of Directors on Intellectual Capital Performance for Banks Listed in Gulf Markets

This study aims at exploring the relationship between characteristics of board of directors (size, educational level, nationality, number of meetings) on intellectual capital performance for banks listed in the Gulf markets. The study was based on analysing annual reports of a sample of (86) banks for (5) five years from 2014 to 2018. The study also used the technique of correlation and regression to analyse the relationship among study variables. The results indicate that the size of board of directors is positively highly correlated with intellectual capital performance. In addition, this study finds an important positive correlation between educational level and intellectual capital performance This supports the idea that diversity in educational level of board of directors reflects their varying degrees of knowledge and skills, affecting board of directors’ ability to generate more or less creative solutions to solve complex problems. Furthermore, this is contrary to the expectations of theory of dependence on resources, where this study did not find any relationship between the nationality diversity of board of directors and intellectual capital performance in Gulf banks. Moreover, the study results show that the number of board of director meetings has a relationship with intellectual capital performance.
Family emotional climate and health: Testing conveyance of effects via psychobiological mediators

Funding information John D. and Catherine T. MacArthur Foundation Research Network; National Institute on Aging, Grant/Award Number: P01-AG020166 Abstract Using the Biobehavioral Family Model and data from five Midlife in the United States projects (N = 793), this study tests whether allostatic load and negative affect reactivity convey the effects of categorizations of family emotional climate on health appraisal and morbidity (chronic conditions) across 20 years. Results indicated that negative family emotional climate (high strain, low support/parental affection) was indirectly associated with health appraisal 20 years later via negative affect reactivity at 10 years. Ambivalent family emotional climate (high strain/support) was directly associated with greater morbidity. Allostatic load did not serve as a significant mediator in the models tested. Findings suggest that family emotional climates marked by strain and intensity may be especially problematic for health, partly by exacerbating negative affect reactivity.
Seismicity and seismotectonics of the Albstadt Shear Zone in the northern Alpine foreland

Abstract. The region around the town Albstadt, SW Germany, was struck by four damaging earthquakes with magnitudes greater than 5 during the last century. These earthquakes occurred along the Albstadt Shear Zone (ASZ), which is characterized by more or less continuous microseismicity. As there are no visible surface ruptures that may be connected to the fault zone, we study its characteristics by its seismicity distribution and faulting pattern. We use the earthquake data of the state earthquake service of Baden-Württemberg from 2011 to 2018 and complement it with additional phase picks beginning in 2016 at the AlpArray and StressTransfer seismic networks in the vicinity of the ASZ. This extended data set is used to determine new minimum 1-D seismic vp and vs velocity models and corresponding station delay times for earthquake relocation. Fault plane solutions are determined for selected events, and the principal stress directions are derived. The minimum 1-D seismic velocity models have a simple and stable layering with increasing velocity with depth in the upper crust. The corresponding station delay times can be explained well by the lateral depth variation of the crystalline basement. The relocated events align about north–south with most of the seismic activity between the towns of Tübingen and Albstadt, east of the 9∘ E meridian. The events can be separated into several subclusters that indicate a segmentation of the ASZ. The majority of the 25 determined fault plane solutions feature an NNE–SSW strike but NNW–SSE-striking fault planes are also observed. The main fault plane associated with the ASZ dips steeply, and the rake indicates mainly sinistral strike-slip, but we also find minor components of normal and reverse faulting. The determined direction of the maximum horizontal stress of 140–149∘ is in good agreement with prior studies. Down to ca. 7–8 km depth SHmax is bigger than SV; below this depth, SV is the main stress component. The direction of SHmax indicates that the stress field in the area of the ASZ is mainly generated by the regional plate driving forces and the Alpine topography.
The Effect of Enamel Pre-treatment with Silver Diamine Fluoride versus Nano Silver Fluoride on the Microleakage of Fissure Sealant: in vitro study.

Abstract: Many studies in literature showed the effectiveness of silver diamine fluoride (SDF) and Nano silver fluoride (NSF) as preventive agents. However, there is little evidence regarding the retention properties of fissure sealant (FS) when applied on a surface previously treated with these preventive agents. Objective: To evaluate and compare the effect of fissure pre-treatment with SDF versus NSF on the microleakage of FS in permanent teeth. Methods: This experimental in vitro study was performed on 45 extracted human premolars, teeth were randomly assigned into three groups according to the type of fissure treatment: Group I: Control group (sealant only), Group II: SDF group (pre-treatment before sealant), and Group III: NSF group (pre-treatment before sealant). Teeth were thermos-cycled and then immersed in 2% methylene blue solution for 24 hours, teeth were then sectioned mesio-distally in the middle of the fissure, and examined under the stereomicroscope for dye penetration. Results: There was no statistical significant difference in the microleakage scores between the three groups (p=0.247). Conclusion: Pretreatment of the pits and fissure with SDF or NSF prior to sealant application did not affect the micro-leakage of the FS.
The Saudi University Students’ Experience of Flipping the English Language Classroom

Flipping the classroom is not a newly applied instructional method in EFL (English as a Foreign Language) educational settings. It entails that what is conventionally completed in the classroom is now done at home and the sequence is reversed. Numerous researchers expanded on the highly positive attitudes the students hold towards this method. However, revisiting this aspect of research is always recommended, especially in unexplored educational settings, as it is the case in this current paper which was conducted in a Saudi context. More interestingly, the results obtained through the use of a questionnaire and a semi-structured interview contradicted most of the previous ones. As a matter of fact, the Saudi learners of English informing this research expressed no favourable attitude or enjoyment of the flip model. Such negativity could be either gender-based or attributed to the challenges such method could pose which are related to the learning styles of the Saudis. Further implications are discussed throughout the paper.
Performance and meat quality of broiler chicken fed a ration containing flaxseed meal and higher dietary lysine levels

Abstract The present study aimed to evaluate growth performance and meat quality of broiler chicken with respect to feeding of 100 g flaxseed meal (FM)/kg and increasing lysine levels in the broiler diet. The results revealed no effect of lysine and FM feeding on growth performance except for a negative effect of FM on feed efficiency of birds, which was countered by feeding 1.25 BIS lysine. Feeding FM improved the fatty acid profile of broiler chicken meat significantly, whereas no effect was observed for increasing lysine levels beyond BIS recommendation. FM significantly reduced meat cholesterol, fat, water-holding capacity (WHC), extract release volume (ERV) and antioxidant potential, whereas it increased the pH of fresh meat, drip loss and lipid peroxidation of broiler chicken meat. As compared with other lysine levels, generally 1.25 BIS lysine significantly increased the pH of refrigerated stored meat, WHC, ERV and antioxidant potential, whereas it significantly reduced cholesterol, fat, drip loss and lipid peroxidation of broiler chicken meat. Thus, the inclusion of 100 g FM/kg diet along with 1.25 BIS lysine in broiler ration was optimum for desirable broiler performance, fatty acid profile, oxidative stability and other functional properties of broiler chicken meat.
European Union Enlargement in 2004, Euro adoption and Trade Spillovers: A Near-Var Approach

This paper evaluates trade contagion before and after the accession of Central and Eastern European (CEE) countries to the European Union in 2004. A near-VAR model is used in order to capture both the direct and indirect shock transmissions via bilateral trade relationships. Empirical results reveal that CEE economies respond more strongly to a European shock after 2004 than before. Furthermore, we also find that trade spillovers increased mostly for CEE countries that have adopted the euro. Finally, transmission of shocks is mainly due to the biggest countries of the Euro area.