Miracle-dz/UniFAR-FTUs huggingface dataset:
GluN3-Containing NMDA Receptors in the Rat Nucleus Accumbens Core Contribute to Incubation of Cocaine Craving

Cue-induced cocaine craving progressively intensifies (incubates) after withdrawal from cocaine self-administration in rats and humans. In rats, the expression of incubation ultimately depends on Ca2+-permeable AMPARs that accumulate in synapses onto medium spiny neurons (MSNs) in the NAc core. However, the delay in their accumulation (∼1 month after drug self-administration ceases) suggests earlier waves of plasticity. This prompted us to conduct the first study of NMDAR transmission in NAc core during incubation, focusing on the GluN3 subunit, which confers atypical properties when incorporated into NMDARs, including insensitivity to Mg2+ block and Ca2+ impermeability. Whole-cell patch-clamp recordings were conducted in MSNs of adult male rats 1-68 d after discontinuing extended-access saline or cocaine self-administration. NMDAR transmission was enhanced after 5 d of cocaine withdrawal, and this persisted for at least 68 d of withdrawal. The earliest functional alterations were mediated through increased contributions of GluN2B-containing NMDARs, followed by increased contributions of GluN3-containing NMDARs. As predicted by GluN3-NMDAR incorporation, fewer MSN spines exhibited NMDAR-mediated Ca2+ entry. GluN3A knockdown in NAc core was sufficient to prevent incubation of craving, consistent with biotinylation studies showing increased GluN3A surface expression, although array tomography studies suggested that adaptations involving GluN3B also occur. Collectively, our data show that a complex cascade of NMDAR and AMPAR plasticity occurs in NAc core, potentially through a homeostatic mechanism, leading to persistent increases in cocaine cue reactivity and relapse vulnerability. This is a remarkable example of experience-dependent glutamatergic plasticity evolving over a protracted window in the adult brain. SIGNIFICANCE STATEMENT “Incubation of craving” is an animal model for the persistence of vulnerability to cue-induced relapse after prolonged drug abstinence. Incubation also occurs in human drug users. AMPAR plasticity in medium spiny neurons (MSNs) of the NAc core is critical for incubation of cocaine craving but occurs only after a delay. Here we found that AMPAR plasticity is preceded by NMDAR plasticity that is essential for incubation and involves GluN3, an atypical NMDAR subunit that markedly alters NMDAR transmission. Together with AMPAR plasticity, this represents profound remodeling of excitatory synaptic transmission onto MSNs. Given the importance of MSNs for translating motivation into action, this plasticity may explain, at least in part, the profound shifts in motivated behavior that characterize addiction.
Evaluating the Arrhenius equation for developmental processes

The famous Arrhenius equation is well suited to describing the temperature dependence of chemical reactions but has also been used for complicated biological processes. Here, we evaluate how well the simple Arrhenius equation predicts complex multi‐step biological processes, using frog and fruit fly embryogenesis as two canonical models. We find that the Arrhenius equation provides a good approximation for the temperature dependence of embryogenesis, even though individual developmental intervals scale differently with temperature. At low and high temperatures, however, we observed significant departures from idealized Arrhenius Law behavior. When we model multi‐step reactions of idealized chemical networks, we are unable to generate comparable deviations from linearity. In contrast, we find the two enzymes GAPDH and β‐galactosidase show non‐linearity in the Arrhenius plot similar to our observations of embryonic development. Thus, we find that complex embryonic development can be well approximated by the simple Arrhenius equation regardless of non‐uniform developmental scaling and propose that the observed departure from this law likely results more from non‐idealized individual steps rather than from the complexity of the system.
The Impact of COVID-19 on Villages: Results from a National Survey

ABSTRACT Villages are consumer-driven organizations that promote aging-in-place. This study documents the effects of the COVID-19 pandemic on Villages and explores variation in response by age of the organization, size of the membership, staffing model, and geographic location. In summer, 2020, we distributed an online survey to executive administrators of 286 Villages in the network. During the pandemic, over 75% of Villages were seen as more or equally valuable for members. Seventy-seven percent of Villages offered virtual socialization events. Most Villages reported a decrease in service requests, given reductions in need for transportation. New services of food and medication delivery were initiated. There is much variation between organizations, but findings suggest that Villages that are older, have more members, and bigger budgets had more capacity and cushion; and although they took a negative hit in income and participation, it was a smaller hit proportionately, compared to younger and smaller Villages. Villages have demonstrated adaptability and creativity. They kept their operations running, provided services, and offered social connection. Vulnerabilities have been exposed: memberships have dropped for many and some members have not been able to participate as before the pandemic. Many lessons learned can help future developments of the Village model.
Recovery of the ascending reticular activating system and consciousness following comprehensive management in a patient with traumatic brain injury: a case report

We report on changes in the ascending reticular activating system (ARAS) concurrent with the recovery of impaired consciousness following rehabilitation and cranioplasty in a patient with traumatic brain injury (TBI), which were demonstrated on diffusion tensor tractography (DTT). A 34-year-old male patient was diagnosed with a traumatic intracerebral hemorrhage after falling from a height of approximately 7 m and underwent a right frontoparietotemporal decompressive craniectomy and hematoma removal. At 5 months after onset, when starting rehabilitation, the patient showed impaired consciousness, with a Glasgow Coma Scale (GCS) score of 4. Comprehensive rehabilitative therapy was provided until 14 months after onset, and his GCS score improved to 8. Cranioplasty was performed using auto-bone at 14 months after onset. One month after cranioplasty, his GCS score improved to 12. On the 15-month DTT, the deviated lower dorsal ARAS was restored on both sides, and the right side had become thicker. The right lower ventral ARAS was reconstructed, and increased neural connectivity of the upper ARAS was detected in both the prefrontal cortices. Thus, changes in the ARAS were demonstrated in a patient with TBI during recovery of consciousness following rehabilitation and cranioplasty.
Face-Based Judgments: Accuracy, Validity, and a Potential Underlying Mechanism

Despite the pervasiveness of facial inferences, scholars have debated whether our face reflects valid information regarding how we actually behave. Whereas previous research has largely focused on the accuracy of facial inferences, the present research examined the validity of face-based judgments. Specifically, we tested how accurate face-based judgments are, whether the accuracy of and confidence in face-based judgments are associated, and what mechanisms potentially link facial appearance to behaviors (N = 1,386 American and Korean adults). We found that although face-based judgments could accurately predict someone’s behavior (Study 1), participants’ confidence about their face-based judgments was not associated with their accuracy (Studies 2a and 2b). Moreover, Study 3 demonstrated that the accuracy of facial inferences is possibly due to self-fulfilling effects of facial inferences. That is, accuracy is largely driven by perceivers’ beliefs rather than by the direct association between faces and behaviors.
Relationship Between Ethical Attitudes and the Dark Triad: Differences Among College Majors

Abstract This study examined the relationship between the Dark Triad (narcissism, Machiavellianism, and psychopathy), ethical attitudes, college major, and social desirability. Researchers investigated if business and psychology majors differed on the Dark Triad and ethical attitudes. In addition, social desirability was hypothesized to moderate the relationship between the Dark Triad and ethical attitudes. In total, 383 upper division business and psychology students from a large public university were surveyed online. Results showed a significant negative correlation between the Dark Triad and ethical attitudes. Business majors have significantly higher levels of psychopathy and lower levels of ethical attitudes compared to psychology majors, and social desirability moderates the relationship between psychopathy and ethical attitudes. Given the deleterious nature of the Dark Triad, and the negative impact of unethical behavior in the workplace, the findings underscore the need for future research that further examines differences between majors on these variables.
[Factors related to subjective evaluation of quality of life of diabetic patients].

OBJECTIVE To determine the relationship between some clinical and psychosocial factors and the quality of life of a group of diabetic patients. METHOD A cross sectional study was done with diabetic patients attending a primary care unit. Quality of life was evaluated with a verbal global scale. The clinical and psychosocial factors studied were: type of diabetes, duration of the disease, type of treatment, associated diseases, complications, metabolic control (glycosylated hemoglobin), treatment compliance, coping styles, negative attitude to disease, social support, and socioeconomical level. RESULTS We interviewed 173 patients, most women (739%), most type 2 (95%). We found that being a woman was a factor negatively related to quality of life. Of clinical variables, only duration of disease was slightly correlated with quality of life (-0.14). Psychological and social variables were significantly correlated with quality of life. We performed a stepwise multiple regression analysis and we found that seven psychosocial variables explained 30% of variance of quality of life. CONCLUSIONS Our results indicate that clinical factors did not correlate with quality of life. It is the way the patient lives with diabetes and not the diabetes by itself what affects the quality of life of diabetic patients. Some psychological and social variables were significantly related to quality of life of these patients.
Identification of Phytophthora spp. from perennial crops in Malaysia, its pathogenicity and cross-pathogenicity

Phytophthora is one of the most important plant pathogens of perennial crops in the tropics. This study characterised the pathogen(s) responsible for cocoa black pod rot, rubber pod rot and durian stem canker. Eighteen Phytophthora isolates were collected from several states in Malaysia, namely Pahang, Johor and Selangor. A total of 12 Phytophthora palmivora and six Phytophthora nicotianae isolates were isolated and identified based on the morphological and molecular characteristics. Internal transcribed spacer (ITS) sequences enabled Phytophthora identification to species level. Inoculation of 18 isolates on detached leaves and unripen cocoa pods successfully demonstrated the progressive development of lesions on its original host. Lesions were also observed in all wounded detached leaves of young durian (clone D24) and rubber (clone RRIM600) and unripen cocoa pods (clone BAL244) regardless of host and isolates. Phytophthora isolates from durian (DSCI) and rubber (R4A) used to inoculate cocoa pods exhibited lesion sizes of 11.6±0.75 and 9.6±0.64 mm, respectively. However, Phytophthora isolates from cocoa (CPR25) developed a longer length of lesion of 18.6±0.47 mm. On durian leaves, Phytophthora isolate from rubber (R4A) and cocoa (CPR25) recorded 11.73±1.04 and 5.22±0.57 mm length of lesion while Phytophthora isolates from durian (DSCB4) produced 13.13±1.29 mm lesion on its native host. Isolates from cocoa (CPR22) and durian (DSCE3) infected rubber leaves with 3.74±0.48 and 2.55±0.31 mm length of lesion, in comparison to rubber isolates (R1B) with 5.43±0.23 mm length of lesion. Differences in the length of lesion demonstrated higher level of virulence on the native host.
Revisiting the Integration Hypothesis: Correlational and Longitudinal Meta-Analyses Demonstrate the Limited Role of Acculturation for Cross-Cultural Adaptation

When moving to a new country or living in that country as ethnic-minority-group members, individuals have to relate to different cultural spheres. Scholars and practitioners commonly agree that how people acculturate influences their psychological and sociocultural adaptation. Integration (or biculturalism), which involves engagement in both one’s heritage culture and the dominant mainstream culture, is considered the most beneficial acculturation strategy. But how robust is the evidence for the role of acculturation in adaptation? Here, we present a reanalysis of a previous meta-analysis of mostly correlational studies (k = 83, N = 23,197) and a new meta-analysis of exclusively longitudinal studies (k = 19, N = 6,791). Results show that the correlational link between acculturation and adaptation is much weaker than previously assumed and that longitudinal evidence is minuscule at best. Our findings suggest that empirical support is still lacking for the most basic premises of acculturation theory.
Examining the Factor Structure of the Anxiety Sensitivity Index-3 in a Turkish Sample: The Factor Structure of the Anxiety Sensitivity Index-3

The purpose of the current study was to investigate the factor structure of the Anxiety Sensitivity Index-3 (ASI-3) in a Turkey sample and to determine measurement invariance of the ASI-3 across gender and age groups. Confirmatory factor analysis was performed on four different models to determine the best fit model for the structure. After the best structure was determined, different models were tested for measurement invariance across gender and age groups. To determine the reliability of the ASI-3, the hierarchical omega coefficient and correlations between the scores obtained from different scales for convergent validity were calculated. It has been determined that the bifactor model is the model that best fits the data, and this model shows invariance across gender and age groups. Besides, evidence regarding the reliability and convergent validity of the ASI-3 was also provided in the study. Current findings show that anxiety sensitivity consists of a general factor (anxiety sensitivity) and three independent specific factors (physical, cognitive, and social concerns). It was concluded that the general factor of anxiety sensitivity constitutes a dominant factor and special factors have a relatively low effect on explaining the structure. Considering the dominance of the general factor, it is recommended to use the ASI-3 total score as a measure of general anxiety sensitivity.
A developmental stage- and Kidins220-dependent switch in astrocyte responsiveness to brain-derived neurotrophic factor.

Astroglial cells are key to maintain nervous system homeostasis. Neurotrophins are known for their pleiotropic effects on neuronal physiology, but also exert complex functions onto glial cells. In this work, we investigated: (i) the signaling competence of embryonic and postnatal primary cortical astrocytes exposed to brain-derived neurotrophic factor (BDNF); and (ii) the role of Kinase D interacting substrate (Kidins220), a transmembrane scaffold protein that mediates neurotrophin signaling in neurons, in the astrocyte response to BDNF. We found a shift from a kinase-based response in embryonic cells to a predominantly [Ca2+]i-based response in postnatal cultures associated with the decreased expression of the full-length BDNF receptor TrkB, with a contribution of Kidins220 to the BDNF-activated kinase and [Ca2+]i pathways. Finally, Kidins220 participates in astrocytes' homeostatic function by controlling the expression of the inwardly rectifying potassium channel (Kir) 4.1 and the metabolic balance of embryonic astrocytes. Overall, our data contribute to the understanding of the complex role played by astrocytes within the central nervous system and identify Kidins220 as a novel actor in the increasing number of pathologies characterized by astrocytic dysfunctions.
This Is Your Brain on Autopilot: Neural Indices of Driver Workload and Engagement During Partial Vehicle Automation

Objective This research explores the effect of partial vehicle automation on neural indices of mental workload and visual engagement during on-road driving. Background There is concern that the introduction of automated technology in vehicles may lead to low driver stimulation and subsequent disengagement from the driving environment. Simulator-based studies have examined the effect of automation on a driver’s cognitive state, but it is unknown how the conclusions translate to on-road driving. Electroencephalographic (EEG) measures of frontal theta and parietal alpha can provide insight into a driver’s mental workload and visual engagement while driving under various conditions. Method EEG was recorded from 71 participants while driving on the roadway. We examined two age cohorts, on two different highway configurations, in four different vehicles, with partial vehicle automation both engaged and disengaged. Results Analysis of frontal theta and parietal alpha power revealed that there was no change in mental workload or visual engagement when driving manually compared with driving under partial vehicle automation. Conclusion Drivers new to the technology remained engaged with the driving environment when operating under partial vehicle automation. These findings suggest that the concern surrounding driver disengagement under vehicle automation may need to be tempered, at least for drivers new to the experience. Application These findings expand our understanding of the effects of partial vehicle automation on drivers’ cognitive states.
Long-Term Outcomes after Early Neonatal Hyperglycemia in VLBW Infants: A Systematic Review

Introduction: Long-term effects of early hyperglycemia in VLBW infants are poorly characterized. The objective of this study was to systematically review the effect of early hyperglycemia on growth, metabolic health, and neurodevelopment after neonatal intensive care unit discharge in VLBW infants. Methods: The systematic review was conducted in accordance with the PRISMA guidelines. A study protocol was registered in PROSPERO (CRD42019123335). Data sources included Ovid MEDLINE, Embase, Cochrane Library, CINAHL, and Scopus. Selected studies included infants with a blood glucose concentration >150 mg/dL (8.3 mmol/L) during the first 28 days of life, a gestational age (GA) <32 weeks, and/or a birth weight <1,500 g and longitudinal data on growth, metabolic health, or neurodevelopment outcomes. The GRADE system was used to assess quality of evidence. Results: Eight studies (n = 987 infants) reported long-term outcomes from 4-month corrected GA to 7 years old. Most studies compared long-term outcomes of preterm infants with and without hyperglycemia. Two studies addressed outcomes related to interventions following early hyperglycemia. Some studies found differences in growth, metabolic health, and neurodevelopment outcomes between VLBW preterm infants with hyperglycemia and without hyperglycemia, while other studies found no differences between groups. The overall graded quality of evidence was low. Conclusions: Well-designed randomized controlled and prospective studies are necessary to determine the effect of early hyperglycemia and its treatment on later metabolic and neurodevelopmental outcomes in VLBW infants. Authors propose a potential study design for standardizing the assessment of long-term metabolic and neurodevelopmental outcomes following early hyperglycemia in preterm infants.
Prevalence and correlates of weight gain attempts across five countries.

OBJECTIVE To determine the prevalence and correlates of weight gain attempts in a pooled sample of adults aged 18 and older from Canada, Australia, the United Kingdom, the United States, and Mexico. METHOD Data collected during 2 years (2018 and 2019) of the International Food Policy Study (N = 42,108) were analyzed. Unadjusted 12-month prevalence of weight gain attempts was estimated based on body mass index (BMI; kg/m2 ), weight perception, country, survey year, and sex. Logistic regression analyses were estimated to determine the sociodemographic correlates (age, race/ethnicity, education, BMI, weight perception, weight perception accuracy, and self-rated mental health) of weight gain attempts among the pooled sample stratified by sex. RESULTS Men (10.4%) were significantly more likely than women (5.4%) to report weight gain attempts (p < .001). Nearly one in five (17.1%) men with a BMI in the "normal" range (≥18.5 to <25.0) reported weight gain attempts. Among both men and women, minority group identity was associated with higher odds, while older age and higher BMI category were associated with lower odds, of reporting weight gain attempts. Country differences over the two survey years showed the prevalence of weight gain attempts in 2019 (vs. 2018) was higher among women in Australia (p < .05) and men in the United States (p < .01). DISCUSSION Weight gain attempts are more common among men, compared to women, across five countries, potentially reflecting the global salience of the pursuit of a muscular body.
Data resource profile: the Korea National Hospital Discharge In-depth Injury Survey

The Korea National Hospital Discharge In-depth Injury Survey (KNHDIS), which was started in 2005, is a national probability survey of general hospitals in Korea with 100 or more beds conducted by the Korea Disease Control and Prevention Agency (KDCA). The KNHDIS captures approximately 9% of discharged cases from sampled hospitals using a 2-stage stratified cluster sampling scheme, among which 13% are injury related cases, defined as S00-T98 (injury, poisoning, and certain other consequences of external causes) using International Classification of Diseases, 10th revision codes. The KNHDIS collects information on characteristics of injury-related discharges in order to understand the scale of injuries, identify risk factors, and provide data supporting prevention policies and intervention strategies. The types of data captured include the hospitals’ information, detailed clinical information, and injury-related codes such as the mechanism, activities undertaken when injured (sports, leisure activities, work, treatment, and education), external causes of the injury, and location of the occurrence of the injury based on the International Classification of External Causes of Injuries. Furthermore, the means of transportation, risk factors for suicide, and toxic substances are recoreded. Annual reports of the KNHDIS are publicly accessible to browse via the KDCA website (http://www.kdca.go.kr) and microdata are available free of charge upon request via email (kcdcinjury@korea.kr).