Miracle-dz/UniFAR-FTUs huggingface dataset:
An analytical solution simulating growth of Lewy bodies

This paper reports a minimal model simulating the growth of a Lewy body (LB). To the best of our knowledge, this is the first model simulating Lewy body growth. The LB is assumed to consist of a central spherical core, which is composed of membrane fragments and various dysfunctional intracellular organelles, and a halo, which is composed of alpha-synuclein fibrils. Membrane fragments and alpha-synuclein monomers are assumed to be produced in the soma at constant rates. The growth of the core and the halo are simulated by the Finke-Watzky model. Analytical (closed-form) solutions describing the growth of the core and the halo are obtained. A sensitivity analysis in terms of model parameters is performed.
Acceleration of Dynamic Ice Loss in Antarctica From Satellite Gravimetry

The dynamic stability of the Antarctic Ice Sheet is one of the largest uncertainties in projections of future global sea-level rise. Essential for improving projections of the ice sheet evolution is the understanding of the ongoing trends and accelerations of mass loss in the context of ice dynamics. Here, we examine accelerations of mass change of the Antarctic Ice Sheet from 2002 to 2020 using data from the GRACE (Gravity Recovery and Climate Experiment; 2002–2017) and its follow-on GRACE-FO (2018-present) satellite missions. By subtracting estimates of net snow accumulation provided by re-analysis data and regional climate models from GRACE/GRACE-FO mass changes, we isolate variations in ice-dynamic discharge and compare them to direct measurements based on the remote sensing of the surface-ice velocity (2002–2017). We show that variations in the GRACE/GRACE-FO time series are modulated by variations in regional snow accumulation caused by large-scale atmospheric circulation. We show for the first time that, after removal of these surface effects, accelerations of ice-dynamic discharge from GRACE/GRACE-FO agree well with those independently derived from surface-ice velocities. For 2002–2020, we recover a discharge acceleration of -5.3 ± 2.2 Gt yr−2 for the entire ice sheet; these increasing losses originate mainly in the Amundsen and Bellingshausen Sea Embayment regions (68%), with additional significant contributions from Dronning Maud Land (18%) and the Filchner-Ronne Ice Shelf region (13%). Under the assumption that the recovered rates and accelerations of mass loss persisted independent of any external forcing, Antarctica would contribute 7.6 ± 2.9 cm to global mean sea-level rise by the year 2100, more than two times the amount of 2.9 ± 0.6 cm obtained by linear extrapolation of current GRACE/GRACE-FO mass loss trends.
How Job Creativity Requirements Affects Employee Creativity: Evidence From a Across-Level Analysis

The present study adopted the Pygmalion perspective and a multilevel theoretical framework to investigate whether creative process engagement mediates the linkage of job creativity requirement with employee creativity. We examined whether team knowledge sharing moderates the aforementioned relationship. We obtained data from 71 supervisors and their 453 employees from three companies in China and applied Hierarchical Linear Modeling (HLM) version 6.08 to test the cross-level hypotheses. The results revealed that creative process engagement mediates the positive linkage of job creativity requirement with employee creativity. In addition, we observed that team knowledge sharing moderates the relationship among job creativity requirement, employee creativity, and creative process engagement. The practical and theoretical implications of the findings are discussed.
Effects of Xylo-Oligosaccharide on the Gut Microbiota of Patients With Ulcerative Colitis in Clinical Remission

Gut microbiota dysbiosis is closely associated with ulcerative colitis (UC). Prebiotic therapy is a potential approach for UC management especially remission maintaining. Xylo-oligosaccharide (XOS) is an efficient prebiotic with proven health benefits and few side effects. However, the effects of XOS on the gut microbiota of patients with UC have not been investigated previously. The aim of this study was to evaluate the prebiotic effects of XOS on the fecal microbiota of patients with UC in clinical remission using an in vitro fermentation model. Five patients with UC in clinical remission and five healthy volunteers were enrolled in this study. Fresh fecal samples of UC patients were diluted and inoculated in yeast extract, casitone and fatty acid (YCFA) medium alone or with XOS. After fermentation for 48 h, samples were collected for 16S rDNA sequencing to investigate the gut microbiota composition. Differences in the gut microbiota between healthy volunteers and UC patients in clinical remission were detected using original fecal samples. Subsequently, the differences between the YCFA medium alone or with XOS samples were analyzed to illustrate the effects of XOS on the gut microbiota of UC patients. In both principal coordinate analysis (PCoA) and principal component analysis (PCA), the fecal samples of UC patients differed from those of healthy volunteers. Linear discriminant analysis effect size (LEfSe) analysis revealed that the relative abundances of g_Roseburia and g_Lachnospiraceae_ND3007_group were higher in healthy volunteers than in UC patients, while o_Lactobacillales abundance showed the opposite trend (P < 0.05). Wilcoxon rank-sum test bar plot showed that the abundances of g_Eubacterium_halli_group and g_Lachnospiraceae_ND3007_group were higher in the healthy volunteers than in the UC patients (P < 0.05). In addition, in UC patients, the Wilcoxon rank-sum test showed that XOS fermentation promoted the growth of bacterial groups including g_Roseburia, g_Bifidobacterium, and g_Lactobacillus, which is beneficial for recovery of intestinal diseases. These results suggest that XOS can relieve dysbiosis in the feces of UC patients in clinical remission and thus represent a potential prebiotic material for maintaining remission.
Design of resonators for the determination of the temperature coefficients of elastic constants of monocrystalline silicon

More accurate sets of the first and second order temperature coefficients are presented for monocrystalline silicon of a low-doped p-type silicon and high-doped n-type silicon. These values are extrapolated from the frequency-temperature curve of high-Q silicon resonators. Three types of resonators have been designed and fabricated using silicon bulk micromachining, each with a mode of vibration depending as close as possible on one of the three independent elastic constants. The electromechanical coupling and the related equivalent circuit of an electrostatic drive have been established for two of these modes. The temperature coefficients of the three independent elastic constants, as well as their estimated variances are computed through the fitting of the measured frequency-temperature curves, compared with the sensitivity of each mode to the elastic constants determined by simulations.
Digital Unwrapping of the Mummy of King Amenhotep I (1525–1504 BC) Using CT

The mummy of King Amenhotep I (18th Dynasty c.1525–1504 BC) was reburied by the 21st Dynasty priests at Deir el-Bahari Royal Cache. In 1881 the mummy was found fully wrapped and was one of few royal mummies that have not been unwrapped in modern times. We hypothesized that non-invasive digital unwrapping using CT would provide insights on the physical appearance, health, cause of death, and mummification style of the mummy of King Amenhotep I. We examined the mummy with CT and generated two- and three-dimensional images for the head mask, bandages, and the virtually unwrapped mummy. CT enabled the visualization of the face of Amenhotep I who died around the age of 35 years. The teeth had minimal attrition. There was no CT evidence of pathological changes or cause of death. The body has been eviscerated via a vertical left flank incision. The heart is seen in the left hemithorax with an overlying amulet. The brain has not been removed. The mummy has 30 amulets/jewelry pieces including a beaded metallic (likely gold) girdle. The mummy suffered from multiple postmortem injuries likely inflicted by tomb robbers that have been likely treated by 21st Dynasty embalmers. These included fixing the detached head and neck to the body with a resin-treated linen band; covering a defect in the anterior abdominal wall with a band and placing two amulets beneath; placement of the detached left upper limb beside the body and wrapping it to the body. The transversely oriented right forearm is individually wrapped, likely representing the original 18th Dynasty mummification and considered the first known New Kingdom mummy with crossed arms at the chest. The head mask is made of cartonnage and has inlaid stone eyes. The digital unwrapping of the mummy of Amenhotep I using CT sets a unique opportunity to reveal the physical features of the King non-invasively, understand the mummification style early in the 18th Dynasty, and the reburial intervention style by 21st Dynasty embalmers. This study may make us gain confidence in the goodwill of the reburial project of the Royal mummies by the 21st dynasty priests.
Interpretation of Frequency Channel-Based CNN on Depression Identification

Online end-to-end electroencephalogram (EEG) classification with high performance can assess the brain status of patients with Major Depression Disabled (MDD) and track their development status in time with minimizing the risk of falling into danger and suicide. However, it remains a grand research challenge due to (1) the embedded intensive noises and the intrinsic non-stationarity determined by the evolution of brain states, (2) the lack of effective decoupling of the complex relationship between neural network and brain state during the attack of brain diseases. This study designs a Frequency Channel-based convolutional neural network (CNN), namely FCCNN, to accurately and quickly identify depression, which fuses the brain rhythm to the attention mechanism of the classifier with aiming at focusing the most important parts of data and improving the classification performance. Furthermore, to understand the complexity of the classifier, this study proposes a calculation method of information entropy based on the affinity propagation (AP) clustering partition to measure the complexity of the classifier acting on each channel or brain region. We perform experiments on depression evaluation to identify healthy and MDD. Results report that the proposed solution can identify MDD with an accuracy of 99±0.08%, the sensitivity of 99.07±0.05%, and specificity of 98.90±0.14%. Furthermore, the experiments on the quantitative interpretation of FCCNN illustrate significant differences between the frontal, left, and right temporal lobes of depression patients and the healthy control group.
Effect of time resolution of meteorological inputs on dynamic thermal rating calculations

Dynamic thermal rating (DTR) of power transmission lines can provide a significant increase in transmission capacity compared to the more traditional static rating. This gained capacity can be used to increase the normal and emergency operational flexibility of power transmission systems. Ampacity values can be determined either directly or indirectly from sag or ambient weather conditions. The most important inputs to weather-based DTR systems are meteorological data. The data can be obtained in the form of instantaneous or averaged values, and with various sampling/update intervals. This study examines the effect of the character of the meteorological inputs on the performance of DTR calculations. The analysis is based on real high-resolution wind and temperature measurements. Owing to the random character of the updates with instantaneous weather data, the averaged inputs provide more accurate estimates of ampacity and temperature. Update intervals of 10 minutes are sufficient, while longer intervals cause significant calculation errors. This could lead to a substantial risk of conductor thermal overload. The presented results can be used for effective data management in DTR systems. They can help to avoid substantial errors in ampacity calculations, thus minimising the risk of transmission system outages and premature ageing of transmission conductors.
Impact of online classes and home confinement on myopia progression in children during COVID-19 pandemic: Digital eye strain among kids (DESK) study 4

Purpose: This study was performed to compare the rate of progression of myopia before and during the COVID-19 pandemic and to assess the risk factors of hastened progression. Methods: All children with myopia of spherical equivalence ≤ −0.5 D with at least two prior documented refractions 6 months and 1 year before were included. The annual progression rate before COVID-19 and during COVID-19 was calculated. Annual myopia progression was categorized as no progression (0), slow progression (<1 D), and fast progression (≥1 D). Results: A total of 133 children (266 eyes) aged 6–18 years were included in the study. Mean annual myopia progression was found to be statistically significant during COVID-19 as compared with pre-COVID-19 (0.90 vs 0.25 D, P < 0.00001). A total of 45.9% of children showed an annual progression of ≥1 D during the pandemic as compared with 10.5% before the COVID-19 (p < 0.00001). In multivariate analysis, history of rapid progression in pre-COVID-19 era (P = 0.002) and sun exposure <1 h/day (P < 0.00001) were found to be independent risk factors for rapid myopia progression. Conclusion: Parents should consider risk of rapid myopia progression in children during current pandemic and children should be provided with socially distant outdoor activities to increase their sun exposure and diminish the rate of myopia progression.
Correlation between choroidal thickness and intraocular pressure control in primary angle-closure glaucoma

Purpose: To study the correlation between choroidal thickness (CT) and IOP control in primary angle-closure glaucoma (PACG). Methods: In total, 61 patients (102 eyes) with PACG underwent subfoveal CT (SFCT) scanning using enhanced depth imaging–optical coherence tomography. The subjects with PACG were further grouped as controlled IOP (≤21 mm Hg on maximal medical therapy) and uncontrolled IOP (>21 mm Hg on maximal medical therapy). The average CT of the PACG eyes was calculated and compared between both groups. A correlation analysis was done between CT and intereye difference in CT with the disease parameters. Results: The mean CT was 274.38 ± 42.10 μm in 102 PACG eyes. SFCT was significantly increased in the uncontrolled IOP group as compared with the controlled IOP group. The mean SFCT was 245.57 ± 62.10 μm in the controlled group and 294.46 ± 51.05 μm in the uncontrolled group (P < 0.01). Factors associated with a thicker choroid were younger age, high IOP, and higher optic nerve head cupping (P < 0.001). Neither the visual field-mean deviation (VF-MD) nor pattern standard deviation (PSD) was found to be associated with overall CT. The intereye asymmetry between CT was significantly associated with poor VF-MD and PSD. Conclusion: PACG eyes with thicker choroid may be a risk factor for poor IOP control on medical anti-glaucoma therapy. Thicker choroid as compared to the fellow eye is a poor prognostic sign and these eyes should be monitored closely.
Surgical outcomes of concomitantly performed penetrating keratoplasty with intrascleral haptic fixation

Purpose: To describe the surgical results of concomitantly performed optical penetrating keratoplasty (PKP) with glued intrascleral haptic fixation (ISHF). Methods: Retrospective review of 18 patients (15–72 years) with best-corrected visual acuity (BCVA) of ≤1/60 subjected to unilateral concomitant optical PKP with ISHF and followed up for 13.11 ± 5.83 months (6–26 months) was undertaken. Results: The most common diagnoses were failed PKP (9/18, 50%) followed by aphakic bullous keratopathy (5/18, 27%). Preoperative glaucoma, peripheral anterior synechiae (PAS), and deep vascularization were present in 7/18 (38.88%), 12/18 (61.11%), and 5/18 (27.77%) patients, respectively. Intraoperatively, concomitant procedures such as pupilloplasty and intraocular lens explant were undertaken in 5/18 (27.277%) patients and 1/18 patients (5.55%) experienced suprachoroidal hemorrhage. At final follow-up, BCVA was ≥6/60 in 50% patients (mean astigmatism: 4.79 ± 1.68D), and 55.55% cases experienced graft failure (90% failed within one year of surgery). The most common causes of graft failure were glaucoma (50%), glaucoma with rejection (20%), rejection (10%), retinal detachment (10%), and suprachoroidal hemorrhage (10%). The ODDS ratio (OR) of having graft failure with the following factors was postoperative secondary interventions (OR: 6), postoperative complications (OR: 2.25), prior failed graft (OR: 1.8), preoperative PAS (OR: 1.75), intraoperative concomitant procedures (OR: 1.5), preoperative glaucoma (OR: 1.33), previous surgeries (OR: 1.24), and deep corneal vessels (OR: 0.66). Conclusion: All patients underlying PKP combined with glued ISHF must be counseled about suboptimal surgical outcomes. Emphasis is laid on appropriate case selection and stringent follow-up during the first year after surgery. Secondary interventions should be undertaken cautiously and judiciously in these patients.
A process oriented class in engineering design: how it works

This paper describes techniques that are used in competency-based, introductory engineering design courses. Material used in the course has been produced and developed by the TIDEE (Transferable Integrated Design in Engineering Education) coalition, an NSF sponsored project with principal investigators at Washington State University, Tacoma Community College and the University of Washington. The course develops creative problem solving techniques, communication and teamwork skills. It emphasizes process improvement rather than evaluating the product and results. This provides an opportunity for students to take risks, try new approaches and gain confidence.
Nonlinear Lift on a Triangular Airfoil in Low-Reynolds-Number Compressible Flow

Numerical and experimental analyses of the aerodynamic performance of a triangular airfoil in low-Reynolds-number compressible flow are performed. This airfoil is one of the candidates for propeller blades on a possible future Martian air vehicle design. Based on past experimental studies conducted in the Mars Wind Tunnel at Tohoku University, this airfoil is known to exhibit nonlinear lift behavior. In the present study, direct numerical simulations of low-Reynolds-number compressible flow over a spanwise periodic triangular airfoil are conducted to identify the source of nonlinear lift. The numerical results reveal that the source of the nonlinear aerodynamic behavior is the lift enhancement provided by the large leading-edge vortex generated. For compressible low-Reynolds-number flow, the wake structure becomes elongated, causing the nonlinear lift enhancement to appear at higher angles of attack compared to the case of incompressible flow.
Hybrid upwind splitting scheme by combining the approaches of Roe and AUFS for compressible flow problems

This paper presents a new robust finite volume shock-capturing scheme based on an improved version of the artificially upstream flux vector splitting (AUFS) scheme. This novel numerical scheme, named AUFSR, is obtained by combining AUFS scheme and the Roe solver. The resulting flux functions can be implemented in a very simple manner, in the form of the Roe solver with modified wave speeds, so that converting an existing AUFS flux into the new fluxes is an extremely simple task. The method handles difficulties encountered by the AUFS scheme, when the artificial diffusion is computed with the Steger-Warming approach in the case where the flux vector does not check the homogenous property. The solution accuracy is further improved by extension to high-order spatial and temporal scheme. Accuracy, efficiency and other essential features of the proposed scheme are evaluated by analysing shock propagation behaviours for both the steady and unsteady compressible flows.
Simple Fabrication of Porous 3D Substrate Polydimethylsiloxane (PDMS) Composited with Polyvinylidene Fluoride-co-Hexafluoropropylene (PVDF-HFP) for Triboelectric Nanogenerator

Abstract Owing to their structural advantages over bulk polymers, porous 3D substrates possess immense potential in triboelectric energy generation. This work reports the effective effort to fabricate the porous structure of polydimethylsiloxane, also known as the sponge-PDMS, by a simple template method. The sodium chloride salt from commodity product is used to create the 300 μm size of pores within the PDMS elastomeric layers, turning affects to the mechanical deformability of the triboelectric nanogenerator (TENG). The inner face of those pores is composited with the PVDF-HFP particles as a piezoelectric fillers. The presence of those fillers can be confirmed and their distribution within porous PDMS is 3D visualized by the synchrotron radiation X-ray tomography. The spatial distribution of the PVDF-HFP made it possible to fabricate the piezo-embedded macroporous TENG with high output power of 7.84 μW, giving over 2-fold enhancement, compared with the sponge-PDMS and even more when compared with the flat PDMS film under the same mechanical force.
Method for assessing discharge in meandering compound channels

Laboratory experiments were conducted in a large-scale meandering compound channel to investigate the flow patterns at the apex and cross-over sections. An equation in curvilinear co-ordinates was derived from the momentum equation and the flow continuity equation. In this equation, two shear stress terms are ignored due to their negligible contributions such that simple expressions are obtained. Several groups of experimental data from the published literature were used to verify this model. Comparison of the experimental and predictive results indicates that the proposed method is capable of accurately forecasting the stage discharge in meandering compound channels. Finally, the simple analytical solution of this model and the velocity parameter are further discussed.