Miracle-dz/UniFAR-FTUs huggingface dataset:
Flexible Interoperable Transceiver (FIT) Program Test Range II: Radio Propagation Measurements at 440, 1360 and 1920 MHz, Ft. Hood, Texas

Radiowave propagation measurements at Ft. Hood, Texas are described. These measurements were made as part of the Flexible Interoperable Transceiver (FIT) Program. The objective of the measurements is to define communication link requirements at 440, 1360, and 1920 MHz. Simultaneous wideband measurements at three frequencies were made using fixed transmitters and a mobile fitted with a multi-channel receiver. The system measured the radio channel impulse response. Data outputs include delay spread and basic transmission loss. These parameters are compared at the three measurement frequencies to determine additional propagation impairments military systems will suffer due to frequency translation from 440 MHz to 1360 MHz and 1920 MHz.
CX3C-chemokine receptor 1 modulates cognitive dysfunction induced by sleep deprivation

Abstract Background: Microglia plays an indispensable role in the pathological process of sleep deprivation (SD). Here, the potential role of microglial CX3C-chemokine receptor 1 (CX3CR1) in modulating the cognition decline during SD was evaluated in terms of microglial neuroinflammation and synaptic pruning. In this study, we aimed to investigat whether the interference in the microglial function by the CX3CR1 knockout affects the CNS's response to SD. Methods: Middle-aged wild-type (WT) C57BL/6 and CX3CR1−/− mice were either subjected to SD or allowed normal sleep (S) for 8 h to mimic the pathophysiological changes of middle-aged people after staying up all night. After which, behavioral and histological tests were used to explore their different changes. Results: CX3CR1 deficiency prevented SD-induced cognitive impairments, unlike WT groups. Compared with the CX3CR1−/− S group, the CX3CR1−/− SD mice reported a markedly decreased microglia and cellular oncogene fos density in the dentate gyrus (DG), decreased expression of pro-inflammatory cytokines, and decreased microglial phagocytosis-related factors, whereas increased levels of anti-inflammatory cytokines in the hippocampus and a significant increase in the density of spines of the DG were also noted. Conclusions: These findings suggest that CX3CR1 deficiency leads to different cerebral behaviors and responses to SD. The inflammation-attenuating activity and the related modification of synaptic pruning are possible mechanism candidates, which indicate CX3CR1 as a candidate therapeutic target for the prevention of the sleep loss-induced cognitive impairments.
Parental Stress as the Mediator Between Symptom Burden and the Quality of Life of Chinese Children With Cancer

Background Because of their cancer and treatment adverse effects, most pediatric oncology patients will experience 1 or more symptoms at one time that can seriously affect their quality of life. Because these children are attached to parents, their symptom burden directly influences the parental stress level and parental interpretations of their children’s quality of life. Objective The aim of this study was to examine the association between child-reported symptom burden and the pediatric quality of life reported by children with cancer and their parents, and whether parental perceived stress mediates these relationships. Methods In a cross-sectional design, convenience sampling was used to recruit 80 parent-child dyads. Advanced statistical methods were adopted to analyze the mediating effects of parental stress between children’s symptom burden and their quality of life. Results The results revealed that parental stress was the mediator in the relationship between child-reported symptom burden and children’s quality of life reported by parents. The results also showed that parental stress was not a mediator in the relationship between child-reported symptom burden and their quality of life. This underscored the differences in interpretations of quality of life reported by children and their parents. Conclusion Children’s symptom burden is an important factor in predicting parental stress level and the quality of life reported by the children. Children’s voice should be incorporated whenever possible. Implications for Practice The knowledge gained from this study will facilitate intervention development to enhance parents’ abilities in stress management and symptom management for their children with the support of the nursing profession.
Comparison between linear incision and punch techniques for bone anchored hearing aid surgery

SUMMARY Objectives To evaluate mean surgical time, incidence of soft tissue reactions, implant survival and intraoperative complications in both minimally invasive ponto surgery (MIPS) and the linear incision with tissue preservation technique (LT). Methods A retrospective review was carried out on 48 bone anchored hearing system (BAHS) patients between 2014 and 2019: 13 patients had undergone LT and formed one group, while 35 patients had undergone MIPS and formed the second group. Mean surgical time, intraoperative complications, implant loss and skin reaction were assessed at each post-operative examination. The Mann-Whitney U test was used for statistical analysis. Results The difference in the mean surgical time of 15 mins for MIPS and 36 mins for LT was statistically significant. No intraoperative complications were reported and implant survival was 100% in both groups. The incidence of adverse skin reactions was 7.7% for the LT group and 0% for the MIPS group at first follow-up examination. Conclusions Surgical mean time is shorter for MIPS, making this procedure more suitable for local anaesthesia and more cost effective. Moreover, both LT and MIPS demonstrate good surgical outcomes in terms of skin reactions according to Holgers score and equally excellent implant survival.
An integrated GIS and micro-simulation system for dynamic routing

Traditionally, GIS can only perform route analysis in a static transportation network. This is probably due to the lack of real-time traffic information and corresponding simulation functionalities. The introduction of a traffic simulation environment, however, provides an opportunity for GIS to sort out this problem. This paper explores how to conduct route analyses in dynamic transportation networks by coupling a microscopic traffic simulation engine (i.e. PARAMICS) with a GIS environment (i.e. MapObjects). An interface for such coupling has been developed, in which PARAMICS simulates the traffic conditions with consideration of incidents and feeds in the dynamic link travel time to the system. With the aid of dynamic path finding algorithms the integrated system can implement routing according to users' requirement. It shows that the integration of traffic simulation system with GIS offers a powerful tool for traffic data management, dynamic analysis and presentation, which in turn supports intelligent transportation planning and management effectively.
High-Resolution Anorectal Manometry—A Prospective Cohort Study in Healthy Infants

ABSTRACT Objectives: Functional gastrointestinal disorders (FGD) are common during early childhood. In severe defecation disorders, anorectal manometry (AM) is done to exclude aganglionosis. High-resolution anorectal manometry (HRAM) can probably improve diagnostics but normative data in infants are scarce. This study aims to provide HRAM data in healthy infants overall and in subgroups of infants with FGD, defined as functional constipation (FC), infant colic (IC), and infant dyschezia (ID) (ROME 3 criteria). Methods: This prospective observational cohort study enrolled healthy term infants, having HRAM at 2 and 6 months, using a water-perfused pediatric anorectal silicone catheter. Data were provided for presence of anorectal waves and recto anal inhibitory reflex (RAIR), volume needed to elicit RAIR and anal resting pressure (ARP). Questionnaires at 2 and 6 months identified subjects with FC, IC, and ID. Results: A total of 187 HRAM investigations were done in 107 infants, without any complications. Normal RAIR was found in all, at least on one occasion. Mean ARP increased between 2- and 6-month investigations in infants without FGD. No other differences in HRAM data could be seen between infants with or without an FGD. At 2 months FC, IC, and ID were seen (2%, 4%, and 17%), whereas at 6 months only FC and ID were seen (7% and 1%). Conclusion: We can provide data on HRAM in infants at 2 and 6 months of age. When performing repeated HRAM in healthy infants, RAIR was found in all subjects. HRAM is safe, easy tolerable, and can be recommended in infants with or without FGD.
Survival after Resuscitated Out-of-Hospital Cardiac Arrest in Patients with Paramedic-Identified ST-Segment Elevation Myocardial Infarction Treated with Primary Percutaneous Coronary Intervention

Abstract Background: ST-segment elevation myocardial infarction (STEMI) is a common cause of out-of-hospital cardiac arrest (OHCA). For these patients, urgent angiography and revascularization is an important treatment goal. There is a lack of data on the prognosis of STEMI patients after OHCA, who are diagnosed and treated by paramedics prior to hospital transport for primary percutaneous coronary intervention (PCI). Methods: Included were adult STEMI patients identified and treated by paramedics in Queensland (Australia) from January 2016 to December 2019, transported to a hospital for primary PCI, and receiving primary PCI. Patients were grouped into those with resuscitated OHCA and those without OHCA. Clinically-important time intervals, angiographic and clinical profiles, and survival were described. Results: Patients with OHCA had longer time intervals from prehospital STEMI identification to reperfusion than those without OHCA (median 97 versus 87 mins, p = 0.001). The former had higher rates of cardiac arrhythmia history (50.5 versus 12.4%, p < 0.001), classified low left ventricular ejection fraction on admission (64.9 versus 50.1%, p = 0.006), and cardiogenic shock (5.2 versus 1.2%, p = 0.011) than the latter. A significantly higher proportion of patients with OHCA had multiple diseased vessels (16.9 versus 8.3%, p = 0.005). In-hospital, 30-day, and one-year mortality was low, being 4.1%, 4.1% and 5.2%, respectively, for STEMI patients with OHCA. The corresponding figures for those without OHCA were 1.6%, 1.8% and 3.3%, respectively. Conclusions: Survival in paramedic-identified STEMI patients treated with primary PCI following OHCA resuscitation was high. Rapid angiography and reperfusion are critical in these patients.
Symptom improvement after transtympanic tube placement in Ménière’s disease: preliminary observations

SUMMARY Objective The treatment of choice for Ménière disease (MD) aims at preventing severity and frequency of vertigo attacks. The purpose of this study was to evaluate the effectiveness of ventilation tube (VT) placement on vertigo control in patients affected by MD with no response to standard medical therapy. Methods 76 consecutive outpatients diagnosed with definite MD who failed medical therapy received VT insertion at the Department of Otolaryngology Head and Neck Surgery, “Ospedale del Mare”, Naples, Italy, with a 3-year follow up. Results Over the long term, VT placement was effective in controlling vertigo in 61.8% of patients. In the control group treated with standard preventive care (SPC) alone, all patients continued to experience recurrent vertigo during the entire study. Comparison of survival curves by using the log-rank test shows that significant differences in survival exist between subjects treated with VT placement and the control sample (p = 0.001). Conclusions Our long-term follow-up confirms that VT placement is an effective and safe management option in intractable definite MD, especially in the elderly or in those refusing more invasive treatments.
Cell Surface Xyloglucan Recognition and Hydrolysis by the Human Gut Commensal Bacteroides uniformis

The omnipresence of xyloglucans in the human diet has led to the evolution of heterogeneous gene clusters in several Bacteroidetes species in the HGM, each specially tuned to respond to the structural variations of these complex plant cell wall polysaccharides. Our research illuminates the complementary roles of syntenic and nonsyntenic XyGUL in B. uniformis in conferring growth on a variety of XyG-derived substrates, providing evidence of glycan-binding protein microadaptation within a single species. ABSTRACT Xyloglucan (XyG) is a ubiquitous plant cell wall hemicellulose that is targeted by a range of syntenic, microheterogeneous xyloglucan utilization loci (XyGUL) in Bacteroidetes species of the human gut microbiota (HGM), including Bacteroides ovatus and B. uniformis. Comprehensive biochemical and biophysical analyses have identified key differences in the protein complements of each locus that confer differential access to structurally diverse XyG side chain variants. A second, nonsyntenic XyGUL was previously identified in B. uniformis, although its function in XyG utilization compared to its syntenic counterpart was unclear. Here, complementary enzymatic product profiles and bacterial growth curves showcase the notable preference of BuXyGUL2 surface glycan-binding proteins (SGBPs) to bind full-length XyG, as well as a range of oligosaccharides produced by the glycoside hydrolase family 5 (GH5_4) endo-xyloglucanase from this locus. We use isothermal titration calorimetry (ITC) to characterize this binding capacity and pinpoint the specific contributions of each protein to nutrient capture. The high-resolution structure of BuXyGUL2 SGBP-B reveals remarkable putative binding site conservation with the canonical XyG-binding BoXyGUL SGBP-B, supporting similar roles for these proteins in glycan capture. Together, these data underpin the central role of complementary XyGUL function in B. uniformis and broaden our systems-based and mechanistic understanding of XyG utilization in the HGM. IMPORTANCE The omnipresence of xyloglucans in the human diet has led to the evolution of heterogeneous gene clusters in several Bacteroidetes species in the HGM, each specially tuned to respond to the structural variations of these complex plant cell wall polysaccharides. Our research illuminates the complementary roles of syntenic and nonsyntenic XyGUL in B. uniformis in conferring growth on a variety of XyG-derived substrates, providing evidence of glycan-binding protein microadaptation within a single species. These data serve as a comprehensive overview of the binding capacities of the SGBPs from a nonsyntenic B. uniformis XyGUL and will inform future studies on the roles of complementary loci in glycan targeting by key HGM species.
Sleep, Pain, and Cognition: Modifiable Targets for Optimal Perioperative Brain Health

The prevention of perioperative neurocognitive disorders is a priority for patients, families, clinicians, and researchers. Given the multiple risk factors present throughout the perioperative period, a multicomponent preventative approach may be most effective. The objectives of this narrative review are to highlight the importance of sleep, pain, and cognition on the risk of perioperative neurocognitive disorders and to discuss the evidence behind interventions targeting these modifiable risk factors. Sleep disruption is associated with postoperative delirium, but the benefit of sleep-related interventions is uncertain. Pain is a risk factor for postoperative delirium, but its impact on other postoperative neurocognitive disorders is unknown. Multimodal analgesia and opioid avoidance are emerging as best practices, but data supporting their efficacy to prevent delirium are limited. Poor preoperative cognitive function is a strong predictor of postoperative neurocognitive disorder, and work is ongoing to determine whether it can be modified to prevent perioperative neurocognitive disorders. Multicomponent interventions are effective in preventing postoperative delirium, and work is ongoing to determine whether they can be effective in preventing other postoperative neurocognitive disorders. Interventions optimizing sleep, pain, and cognition are essential components for clinicians to include in strategies to maximize the recovery of body and mind of vulnerable patients.
External Corrosion in Distribution Systems

Many utilities do not appreciate the fact that routine breaks of metal water mains often result from deterioration caused by gradual external corrosion. The author outlines the basic terms and conditions of galvanic and electrolytic corrosion, summarizes case studies that illustrate causes of external corrosion of underground metal mains and that describe methods to control external corrosion, and discusses the role of soil in external corrosion
The Tridem Project

Telecollaboration takes many forms. This account of work in progress describes a project which has a number of particular features, one of which is identified in its name. It links learners from three different parts of the world in a so called Tridem It was inspired by a number of earlier collaborations. One of us was a founder member of the EU-funded International Email Tandem Network, co-ordinated throughout the 1990s by Helmut Brammerts, of Ruhr-Universitat Bochum, who was a regular practitioner of such three-way exchanges (see Brammerts, 2003). The other took part in a more recent tripartite telecollaborative project, involving students of German from the UK and Australia and mother tongue informants from Friedrich Schiller Universitat Jena, which yielded important insights into the factors which influence the success of synchronous online language learning (see Hampel, Felix, Hauck and Coleman, 2005). Another quite singular aspect of the Tridem project was its use of Lyceum, a piece of synchronous audiographic conferencing software developed in house by the Open University’s Knowledge Media Institute, which is now a standard means of delivering language courses in our institution. In the TRIDEM project students of French in the UK and the US worked online with native speakers in France synchronously in Lyceum and asynchronously in weblogs to complete several collaborative tasks. Meetings covered a period of over 10 weeks in autumn 2005. In addition to the (oral, written and graphic) output produced in Lyceum, project outcomes took the form of several collaborative blogs.
Airborne Measurement System During Validation of Egnos/Gnss Essential Parameters in Landing

Abstract The air transport requires certificate of ground and deck devices, systems and adequate procedures. However applied geodetic techniques and measuring technologies depend on taken undertakings. If one should precisely put standard ground systems and the navigational assistance are overbalancing static geodetic techniques and measuring technologies. However operational activity, depending on the phase of the flight a real requires applying geodetic techniques and measuring Jechnologies time”. As part of conducted air tests they made the validation of four fundamental parameters (accuracy, credibility, availability, continuity) of satellite EGNOS, GNSS signals, made as part of European projects: “Support to the EGNOS APV Operational Implementation - APV MIELEC”, air tests enabled to draw right procedures up and to apply satellite signals in the air transport. Details will be presented in the following article.
Amphilimus- vs. zotarolimus-eluting stents in patients with diabetes mellitus and coronary artery disease: the SUGAR trial

Abstract Aim Patients with diabetes mellitus are at high risk of adverse events after percutaneous revascularization, with no differences in outcomes between most contemporary drug-eluting stents. The Cre8 EVO stent releases a formulation of sirolimus with an amphiphilic carrier from laser-dug wells, and has shown clinical benefits in diabetes. We aimed to compare Cre8 EVO stents to Resolute Onyx stents (a contemporary polymer-based zotarolimus-eluting stent) in patients with diabetes. Methods and results We did an investigator-initiated, randomized, controlled, assessor-blinded trial at 23 sites in Spain. Eligible patients had diabetes and required percutaneous coronary intervention. A total of 1175 patients were randomly assigned (1:1) to receive Cre8 EVO or Resolute Onyx stents. The primary endpoint was target-lesion failure, defined as a composite of cardiac death, target-vessel myocardial infarction, and clinically indicated target-lesion revascularization at 1-year follow-up. The trial had a non-inferiority design with a 4% margin for the primary endpoint. A superiority analysis was planned if non-inferiority was confirmed. There were 106 primary events, 42 (7.2%) in the Cre8 EVO group and 64 (10.9%) in the Resolute Onyx group [hazard ratio (HR): 0.65, 95% confidence interval (CI): 0.44–0.96; Pnon-inferiority < 0.001; Psuperiority = 0.030]. Among the secondary endpoints, Cre8 EVO stents had significantly lower rate than Resolute Onyx stents of target-vessel failure (7.5% vs. 11.1%, HR: 0.67, 95% CI: 0.46–0.99; P = 0.042). Probable or definite stent thrombosis and all-cause death were not significantly different between groups. Conclusion In patients with diabetes, Cre8 EVO stents were non-inferior to Resolute Onyx stents with regard to target-lesion failure composite outcome. An exploratory analysis for superiority at 1 year suggests that the Cre8 EVO stents might be superior to Resolute Onyx stents with regard to the same outcome. Clinical trial registration ClinicalTrials.gov: NCT03321032.
Modelling Methods for Energy in Buildings

Climate change mitigation and sustainable practices are now at the top of political and technical agendas. Environmental system modelling provides a way of appraising options and this book will make a significant contribution to the uptake of such systems. It provides knowledge of the principles involved in modelling systems, builds confidence amongst designers and offers a broad perspective of the potential of these new technologies. The aim of the book is to provide an understanding of the concepts and principles behind predictive modelling methods; review progress in the development of the modelling software available; and explore modelling in building design through international case studies based on real design problems.
Is wireless accelerometry a viable measurement system for assessing vertical jump performance?

The aim of this study was to assess the mechanical differences calculated from hip acceleration (accelerometer attached to the hip), bar acceleration (accelerometer attached to barbell) and centre-of-mass acceleration (force plate) during vertical countermovement jumps (CMJs) and the reliability of each system. Eighteen elite male rugby players served as participants. In relation to the force plate, the bar accelerometer revealed similar peak velocity (PV [2%]) and peak power (PP [2%]), but predicted greater peak force (PF [24%]) during the concentric phase, whereas the hip accelerometer predicted similar PF (2%) but underpredicted PV (21%) and PP (24%) during the concentric phase. Both accelerometer attachments were deemed reliable for assessing PF (correlation coefficient, ICC = 0.80–0.83 and standard error of measurement, SEM = 3–13%), but were low/moderately reliable for monitoring PV and PP (ICC = 0.35–0.77 and SEM = 11–23%). The eccentric phase variables were unreliable across all devices and attachment sites. The kinematics and kinetics measured by the three systems (hip accelerometer, bar accelerometer and force plate) varied significantly (p < 0.05). Based on the outcomes, it is recommended that the force plate be used as the primary means of assessing CMJ performance until the stability of wireless accelerometry set-ups and protocols are improved.