Miracle-dz/UniFAR-FTUs huggingface dataset:
FROM THE BLAZAR SEQUENCE TO THE BLAZAR ENVELOPE: REVISITING THE RELATIVISTIC JET DICHOTOMY IN RADIO-LOUD ACTIVE GALACTIC NUCLEI

We revisit the concept of a blazar sequence that relates the synchrotron peak frequency (νpeak) in blazars with synchrotron peak luminosity (Lpeak, in νLν) using a large sample of radio-loud active galactic nuclei. We present observational evidence that the blazar sequence is formed from two populations in the synchrotron νpeak–Lpeak plane, each forming an upper edge to an envelope of progressively misaligned blazars, and connecting to an adjacent group of radio galaxies having jets viewed at much larger angles to the line of sight. When binned by jet kinetic power (Lkin; as measured through a scaling relationship with extended radio power), we find that radio core dominance decreases with decreasing synchrotron Lpeak, revealing that sources in the envelope are generally more misaligned. We find population-based evidence of velocity gradients in jets at low kinetic powers (∼1042–1044.5 erg s−1), corresponding to Fanaroff–Riley (FR) I radio galaxies and most BL Lac objects. These low jet power “weak-jet” sources, thought to exhibit radiatively inefficient accretion, are distinguished from the population of non-decelerating, low synchrotron-peaking (LSP) blazars and FR II radio galaxies (“strong” jets) which are thought to exhibit radiatively efficient accretion. The two-population interpretation explains the apparent contradiction of the existence of highly core-dominated, low-power blazars at both low and high synchrotron peak frequencies, and further implies that most intermediate synchrotron peak sources are not intermediate in intrinsic jet power between LSP and high synchrotron-peaking (HSP) sources, but are more misaligned versions of HSP sources with similar jet powers.
Splitting of monolayer out-of-plane A 1 ' Raman mode in few-layer WS 2

We present Raman measurements of mono- and few-layer WS2. We study the monolayer A'1 mode around 420 cm(-1) and its evolution with the number of layers. We show that with increasing layer number there is an increasing number of possible vibrational patterns for the out-of-plane Raman mode: in N-layer WS2 there are N Gamma-point phonons evolving from the A'1 monolayer mode. For an excitation energy close to resonance with the excitonic transition energy we were able to observe all of these N components, irrespective of their Raman activity. Density functional theory calculations support the experimental findings and make it possible to attribute the modes to their respective symmetries. The findings described here are of general importance for all other phonon modes in WS2 and other layered transition metal dichalcogenide systems in the few layer regime.
S-TYPE AND P-TYPE HABITABILITY IN STELLAR BINARY SYSTEMS: A COMPREHENSIVE APPROACH. I. METHOD AND APPLICATIONS

A comprehensive approach is provided for the study of both S-type and P-type habitability in stellar binary systems, which in principle can also be expanded to systems of higher order. P-type orbits occur when the planet orbits both binary components, whereas in the case of S-type orbits, the planet orbits only one of the binary components with the second component considered a perturbator. The selected approach encapsulates a variety of different aspects, which include: (1) the consideration of a joint constraint, including orbital stability and a habitable region for a putative system planet through the stellar radiative energy fluxes (“radiative habitable zone”; RHZ), needs to be met; (2) the treatment of conservative, general, and extended zones of habitability for the various systems as defined for the solar system and beyond; (3) the provision of a combined formalism for the assessment of both S-type and P-type habitability; in particular, mathematical criteria are presented for the kind of system in which S-type and P-type habitability is realized; (4) applications of the attained theoretical approach to standard (theoretical) main-sequence stars. In principle, five different cases of habitability are identified, which are S-type and P-type habitability provided by the full extent of the RHZs; habitability, where the RHZs are truncated by the additional constraint of planetary orbital stability (referred to as ST- and PT-type, respectively); and cases of no habitability at all. Regarding the treatment of planetary orbital stability, we utilize the formulae of Holman & Wiegert as also used in previous studies. In this work, we focus on binary systems in circular orbits. Future applications will also consider binary systems in elliptical orbits and provide thorough comparisons to other methods and results given in the literature.
Self-assembling of molecular nanowires for enhancing the conducting properties of discotic liquid crystals

The self-organization of discotic liquid crystal molecules in columns has enormous interest for soft nanoelectronic applications. A great advantage of discotic liquid crystal is that defects can be self-annealed in contrast to typical organic materials. Through the overlap of molecular orbitals, the aromatic cores assemble into long range ordered one-dimensional structures. Very thin structured films can be obtained by spin-coating from solution and the resulting morphologies are strongly dependent on the interaction between discotics and solvent molecules. Toluene produces films formed by very long nanowires, spontaneously aligned along a common direction and over fairly large areas. These nanostructured films are a result of the interplay between liquid crystal self-organization and solvent driven assembly. The ordered nanowire structures exhibit improvement in the electrical properties compared to misaligned structures and even to pristine HAT5, deposited without the aid of solvent. In this study we show that the toluene-based deposition of discotic liquid crystals is advantageous because it allows a uniform coverage of the substrate, unlike pristine HAT5 but also thanks to the type of induced structures exhibiting one order of magnitude higher conductivity, in the aligned nanowire films, compared to bare HAT5 ones.
Ancestors, Artefacts, Empire: Indigenous Australia in British and Irish Museums

cal significance than he deserves, but she cannot escape that this is his story too. Retelling Robinson’s story, she offers an interesting reappraisal that emphasises the intentionality of his mission to remove Indigenous people from Van Diemen’s Land. Robinson’s motives were not only vainglorious and acquisitive, she argues, but also purposely destructive. Robinson knew that Aboriginal Tasmanians’ relationship with the land was profound, that it was the ‘wellspring in their spiritual life and material culture’, and so knew that he must sever that relationship if he were to fulfil his mission to save their souls for God (79). Although unlike others in the community Robinson was not consciously aiming for Indigenous people’s extinction, Pybus shows that he was nonetheless attempting to bring an end to Aboriginal life in Tasmania. Robinson controlled both the future and the past, and when Truganini disappears from his view, she largely disappears from our view too. At the emotional apex of the story – the execution of her companions Peevay and Maulboyheener for murder in Port Phillip in 1842 – all we know of Truganini’s reaction to these horrific events is that she wept bitterly. This detail is recorded in a brief diary entry. We do not know more, because by this time Robinson himself was no longer interested in Truganini, who disappears from his diaries after this date. Pybus covers the last thirty years of Truganini’s life in a brief final chapter based on snippets of evidence, because there is simply no more source material to go on. We, the beneficiaries of colonisation, can only see what the colonisers wanted us to see. In the final years on the Oyster Cove station, for example, we see Truganini as a colonial curiosity, defined by her ‘grace and ease’ in the water. We are kept far away from her interior thoughts and feelings. None of the above is intended as a criticism. Cassandra Pybus has written an important book, which aims to rescue one of the victims of colonialism from its grip. Ultimately the book fails in that endeavour precisely because of the extent of the colonial control and destruction that it reveals. We glimpse Truganini throughout the narrative, indeed get closer to her and her community than previous efforts to tell the story have done. But she remains tantalisingly out of reach, unable to be rescued from the black hole of colonial destruction.
Allergic Inflammation: Effect of Propolis and Its Flavonoids

The incidence of allergic diseases and their complications are increasing worldwide. Today, people increasingly use natural products, which has been termed a “return to nature”. Natural products with healing properties, especially those obtained from plants and bees, have been used in the prevention and treatment of numerous chronic diseases, including allergy and/or inflammation. Propolis is a multi-component resin rich in flavonoids, collected and transformed by honeybees from buds and plant wounds for the construction and adaptation of their nests. This article describes the current views regarding the possible mechanisms and multiple benefits of flavonoids in combating allergy and allergy-related complications. These benefits arise from flavonoid anti-allergic, anti-inflammatory, antioxidative, and wound healing activities and their effects on microbe-immune system interactions in developing host responses to different allergens. Finally, this article presents various aspects of allergy pathobiology and possible molecular approaches in their treatment. Possible mechanisms regarding the antiallergic action of propolis on the microbiota of the digestive and respiratory tracts and skin diseases as a method to selectively remove allergenic molecules by the process of bacterial biotransformation are also reported.
Brain metastasis from colorectal cancer: Treatment, survival, and prognosis

To investigate the clinical characteristics, survival, prognostic factors, and treatment of brain metastasis (BM) from colorectal cancer (CRC). Twenty-one patients with BM from CRC were retrospectively reviewed. Predictive factors for BM and prognostic factors after the diagnosis of BM were examined by univariate and multivariate COX analysis. The time from the development of extracranial metastases, including lung, bone, and liver, to the occurrence of BM was recorded separately. The median overall survival time was 7 months. In univariate prognostic analysis, median survival with multimodal therapy was better than that with unimodal therapy (10 months vs 3 months, P = .000). In addition, median survival with Karnofsky performance status (KPS) < 70, 1 BM lesion, primary tumor stage of II-III, extracranial lesions < 2, and no extracranial metastasis were much better than the other groups (P < .05 of all). Although there was not a significant difference in median survival between patients receiving combination treatment with bevacizumab and those who did not, treatment with bevacizumab was associated with better survival (10 months vs 5 months, P = .436). The time intervals from bone, liver, and lung metastases to BM were 3, 6.5, and 11 months, respectively. Based on multivariate Cox analysis, KPS and treatment modalities were independent prognosis factors (P = .039 and P = .000, respectively). CRC patients with a high KPS and multimodal treatment have improved survival.
Antibody Delivery into the Brain by Radiosensitizer Nanoparticles for Targeted Glioblastoma Therapy

Background Glioblastoma is the most lethal primary brain malignancy in adults. Standard of care treatment, consisting of temozolomide (TMZ) and adjuvant radiotherapy (RT), mostly does not prevent local recurrence. The inability of drugs to enter the brain, in particular antibody-based drugs and radiosensitizers, is a crucial limitation to effective glioblastoma therapy. Methods Here, we developed a combined strategy using radiosensitizer gold nanoparticles coated with insulin to cross the blood-brain barrier and shuttle tumor-targeting antibodies (cetuximab) into the brain. Results Following intravenous injection to an orthotopic glioblastoma mouse model, the nanoparticles specifically accumulated within the tumor. Combining targeted nanoparticle injection with TMZ and RT standard of care significantly inhibited tumor growth and extended survival, as compared to standard of care alone. Histological analysis of tumors showed that the combined treatment eradicated tumor cells, and decreased tumor vascularization, proliferation, and repair. Conclusions Our findings demonstrate radiosensitizer nanoparticles that effectively deliver antibodies into the brain, target the tumor, and effectively improve standard of care treatment outcome in glioblastoma.
Anacardium occidentale Bark as an Antidiabetic Agent

Anacardium occidentale L. is used throughout the world to treat type 2 diabetes. In Portugal, a traditional herbal preparation made with stem bark of this species (AoBTHP) has been used for more than 30 years to treat this pathology. The AoBTHP was standardized on total phenolic content, and its hypoglycemic activity was assessed using db/db mice (n = 26) for 92 days. Three doses (40.2, 71.5, and 127.0 mg/kg/day, per os) were tested, and glibenclamide (5 mg/kg/day) was used as positive control. During the study, glycemia was measured under non-fasting or fasting states. In sequence, thin-layer chromatography bioautographic assays were used for the detection of possible alpha- and beta-glucosidase inhibitors. A significant hypoglycemic effect in fasting glycemia in days 31 and 57 was observed with the three tested doses. The 71.5 mg/kg and 127.0 mg/kg AoBTHPs significantly reduced non-fasting glycemia on day 24. The highest dose showed the most significant hypoglycemic effect. Gallic acid was identified as the major alpha- and beta-glucosidase inhibitor. The 127 mg/kg/day AoBTHP dose showed a greater glucose-lowering effect than glibenclamide. For the first time, a standardized AoBTHP was tested using an in vivo diabetes model, and its usage was preclinically validated for type 2 diabetes treatment. The hypoglycemic activity of an AoBTHP can be related to the presence of alpha- and beta-glucosidase inhibitors, such as gallic acid, but other mechanisms can also be involved.
Earth-grazing daylight fireball of August 10, 1972

A daylight fireball flew over the U.S. and Canada on Aug 10, 1972 with its trajectory tangential to the Earth surface and perigee at ≃ 58 km. The fireball body lost only a part of its mass and continued to move in a changed orbit. Unique observations by infrared radiometer tracking were acquired by Rawcliffe et al. (1974). The original paper and also Jacchia's paper (1974) on this fireball both contain several mistakes and misprints. This paper brings correct values and refers to my original paper (1979) for details. Especially, the extremely large mass of this meteoroid, frequently cited from Jacchia's paper, is not correct. New models of meteoroid ablation and fragmentation applied to this fireball yielded ≃ 5 m as the most probable size of the body at perigee
A tidal disruption flare in a massive galaxy? Implications for the fuelling mechanisms of nuclear black holes

Wearguethatthe'changinglook'activegalacticnucleus(AGN)recentlyreportedbyLaMassa etal.couldbealuminousflareproducedbythetidaldisruptionofasupersolarmassstarpassing just a few gravitational radii outside the event horizon of a ∼10 8 Mnuclear black hole. This flare occurred in a massive, star-forming galaxy at redshift z = 0.312, robustly characterized thanks to repeated late-time photometric and spectroscopic observations. By taking difference photometry of the well-sampled multiyear Sloan Digital Sky Survey (SDSS) Stripe-82 light curve,weareabletoprobetheevolutionofthenuclearspectrumoverthecourseoftheoutburst. The tidal disruption event (TDE) interpretation is consistent with the very rapid rise and the decay time of the flare, which displays an evolution consistent with the well-known t −5/3 behaviour (with a clear superimposed re-brightening flare). Our analysis places constraints on the physical properties of the TDE, such as the putative disrupted star's mass and orbital parameters, as well as the size and temperature of the emitting material. The properties of the broad and narrow emission lines observed in two epochs of SDSS spectra provide further constraints on the circum-nuclear structure, and could be indicative that the system hosted a moderate-luminosity AGN as recently as a few 10 4 yr ago, and is likely undergoing residual accretion as late as 10 yr after peak, as seen from the broad Hα emission line. We discuss the complex interplay between TDEs and gas accretion episodes in galactic nuclei, highlighting the implications for future TDE searches and for estimates of their intrinsic rates.
Deciphering the Key Regulatory Roles of KLF6 and Bta-miR-148a on Milk Fat Metabolism in Bovine Mammary Epithelial Cells

MicroRNAs (miRNAs) are non-coding RNAs that regulate the expression of their target genes involved in many cellular functions at the post-transcriptional level. Previously, bta-miR-148a showed significantly high expression in bovine mammary epithelial cells (BMECs) of Chinese Holstein cows producing high milk fat compared to those with low milk fat content. Here, we investigated the role of bta-miR-148a through targeting Krüppel-like factor 6 (KLF6) and further analyzed the role of KLF6 in regulating fat metabolism through targeting PPARA, AMPK/mTOR/PPARG, and other fat marker genes in BMECs of Chinese Holstein. The bioinformatics analysis showed that the 3’ UTR of KLF6 mRNA possesses the binding sites for bta-miR-148a, which was further verified through dual-luciferase reporter assay. The BMECs were transfected with bta-miR-148a-mimic, inhibitor, and shNC, and the expression of KLF6 was found to be negatively regulated by bta-miR-148a. Moreover, the contents of triglyceride (TG), and cholesterol (CHO) in BMECs transfected with bta-miR-148a-mimic were significantly lower than the contents in BMECs transfected with bta-miR-148a-shNC. Meanwhile, the TG and CHO contents were significantly increased in BMECs transfected with bta-miR-148a-inhibitor than in BMECs transfected with bta-miR-148a-shNC. In addition, the TG and CHO contents were significantly decreased in BMECs upon the down-regulation of KLF6 through transfection with pb7sk-KLF6-siRNA1 compared to the control group. Contrarily, when KLF6 was overexpressed in BMECs through transfection with pBI-CMV3-KLF6, the TG and CHO contents were significantly increased compared to the control group. Whereas, the qPCR and Western blot evaluation of PPARA, AMPK/mTOR/PPARG, and other fat marker genes revealed that all of the genes were considerably down-regulated in the KLF6-KO-BMECs compared to the normal BMECs. Taking advantage of deploying new molecular markers and regulators for increasing the production of better-quality milk with tailored fat contents would be the hallmark in dairy sector. Hence, bta-miR-148a and KLF6 are potential candidates for increased milk synthesis and the production of valuable milk components in dairy cattle through marker-assisted selection in molecular breeding. Furthermore, this study hints at the extrapolation of a myriad of functions of other KLF family members in milk fat synthesis.
Microwave noise in semiconductor devices

Preface. List of Symbols. Introduction. Kinetic Theory of Nonequilibrium Processes. Fluctuations: Kinetic Theory. Effect of Interelectron Collisions on Fluctuation Phenomena. Boltzmann--Langevin Equation. Fluctuations and Diffusion. Features of Hot--Electron Fluctuation Spectra. Experimental Techniques. Hot--Electron Microwave Noise in Elementary Semiconductors. Hot--Electron Microwave Noise in GaAs and InP. Length--Dependent Hot--Electron Noise. Hot--Electron Noise in Doped Semiconductors: Theory. Electronic Noise in Standard--Doped n--Type GaAs. Electron Diffusion in Standard--Doped n--Type GaAs. Electronic Subbands in Quantum Wells. Hot--Electron Noise in ALGaAs/GaAs 2DEG Channels. Hot--Electron Noise in InP--Based 2DEG Channels. Cutoff Frequencies of Fast and Ultrafast Processes. Spatially Inhomogeneous Fluctuations. Monte Carlo Approach to Microwave Noise in Devices. Bibliography. Index.
Phase diagram of 4 He on graphene

The low temperature phase diagram of $^4$He adsorbed on a single graphene sheet is studied by computer simulation of a system comprising nearly thousand helium atoms. In the first layer, two commensurate solid phases are observed, with fillings 1/3 and 7/16 respectively, separated by a domain wall phase, as well as an incommensurate crystal at higher coverage. No evidence of a thermodynamically stable superfliuid phase is found for the first adlayer. Second layer promotion occurs at a coverage of 0.111(4) $\AA^{-2}$. In the second layer two phases are observed, namely a superfluid and an incommensurate solid, with no commensurate solid intervening between these two phases. The computed phase diagram closely resembles that predicted for helium on graphite.
Dynamic radio spectra from two fireballs

We present dynamic spectra from the Long Wavelength Array telescope of two large meteors (fireballs) observed to emit between 37 and 54 MHz. These spectra show the first ever recorded broadband measurements of this newly discovered VHF emission. The spectra show that the emission is smooth and steep, getting very bright at lower frequencies. We suggest that this signal is possibly emission of Langmuir waves and that these waves could be excited by a bump‐on‐tail instability within the trail. The spectra of one fireball display broadband temporal frequency sweeps. We suggest that these sweeps are evidence of individual expanding clumps of emitting plasma. While some of these proposed clumps may have formed at the very beginning of the fireball event, others must have formed seconds after the initial event.
Self-regulated star formation in galaxies via momentum input from massive stars

Feedback from massive stars is believed to play a critical role in shaping the galaxy mass function, the structure of the interstellar medium (ISM) and the low efficiency of star formation, but the exact form of the feedback is uncertain. In this paper, the first in a series, we present and test a novel numerical implementation of stellar feedback resulting from momentum imparted to the ISM by radiation, supernovae and stellar winds. We employ a realistic cooling function, and find that a large fraction of the gas cools to ≲100 K, so that the ISM becomes highly inhomogeneous. Despite this, our simulated galaxies reach an approximate steady state, in which gas gravitationally collapses to form giant ‘molecular’ clouds (GMCs), dense clumps and stars; subsequently, stellar feedback disperses the GMCs, repopulating the diffuse ISM. This collapse and dispersal cycle is seen in models of Small Magellanic Cloud (SMC)-like dwarfs, the Milky Way and z∼ 2 clumpy disc analogues. The simulated global star formation efficiencies are consistent with the observed Kennicutt–Schmidt relation. Moreover, the star formation rates are nearly independent of the numerically imposed high-density star formation efficiency, density threshold and density scaling. This is a consequence of the fact that, in our simulations, star formation is regulated by stellar feedback limiting the amount of very dense gas available for forming stars. In contrast, in simulations without stellar feedback, i.e. under the action of only gravity and gravitationally induced turbulence, the ISM experiences runaway collapse to very high densities. In these simulations without feedback, the global star formation rates exceed observed galactic star formation rates by 1–2 orders of magnitude, demonstrating that stellar feedback is crucial to the regulation of star formation in galaxies.