Miracle-dz/UniFAR-FTUs huggingface dataset:
An Analysis of the Aerosol Lifecycle Over India: COALESCE Intercomparison of Three General Circulation Models

Atmospheric aerosols or atmospheric particulate matter affects climate variables like temperature and rainfall, agricultural productivity, soil, and human health. We evaluated aerosol lifecycle over India via simulations (2005–2014) from three general circulation models under the COALESCE project (carbonaceous aerosol emissions, source apportionment, and climate impacts; Venkataraman et al., 2020, 10.1175/bams‐d‐19‐0030.1). The ECHAM6.3‐HAM2.3, CAM5.3, and NICAM‐SPRINTARS simulations use identical regional emissions (from the Speciated Multi‐pollutant generator, SMoG‐India‐v1). Satisfactory model simulations of meteorological variable magnitudes and seasonal cycle have been achieved partly from the adoption of nudging. Estimations of anthropogenic aerosol, aerosol optical depth (AOD), and particulate matter surface concentrations are significantly improved from (a) dust tuning (b) use of satellite‐derived organic aerosol to carbon ratio, and (c) nudged meteorology to capture variables influencing the production of secondary sulfate. Larger wintertime under prediction (−30% to −60%) results from over prediction of seasonal planetary boundary layer height and the absence of secondary ammonium nitrate and organic aerosols. Vertical dispersion to higher altitudes than in observations calls for improved modeling of vertical mass flux representation. Carbonaceous aerosol residence time and AOD fraction larger than global mean values in India, with a seasonal predominance in the autumn and winter seasons can be explained by enhanced regional emissions from residential biofuel cooking, agricultural stubble burning, and traditional informal industries like brick production.
Functionalized Mesoporous Silica Nanoparticles for Drug-Delivery to Multidrug-Resistant Cancer Cells

Background Multidrug resistance is a common reason behind the failure of chemotherapy. Even if the therapy is effective, serious adverse effects might develop due to the low specificity and selectivity of antineoplastic agents. Mesoporous silica nanoparticles (MSNs) are promising materials for tumor-targeting and drug-delivery due to their small size, relatively inert nature, and extremely large specific surfaces that can be functionalized by therapeutic and targeting entities. We aimed to create a fluorescently labeled MSN-based drug-delivery system and investigate their internalization and drug-releasing capability in drug-sensitive MCF-7 and P-glycoprotein-overexpressing multidrug-resistant MCF-7 KCR cancer cells. Methods and Results To track the uptake and subcellular distribution of MSNs, particles with covalently coupled red fluorescent Rhodamine B (RhoB) were produced (RhoB@MSNs). Both MCF-7 and MCF-7 KCR cells accumulated a significant amount of RhoB@MSNs. The intracellular RhoB@MSN concentrations did not differ between sensitive and multidrug-resistant cells and were kept at the same level even after cessation of RhoB@MSN exposure. Although most RhoB@MSNs resided in the cytoplasm, significantly more RhoB@MSNs co-localized with lysosomes in multidrug-resistant cells compared to sensitive counterparts. To examine the drug-delivery capability of these particles, RhoB@Rho123@MSNs were established, where RhoB-functionalized nanoparticles carried green fluorescent Rhodamine 123 (Rho123) - a P-glycoprotein substrate – as cargo within mesopores. Significantly higher Rho123 fluorescence intensity was detected in RhoB@Rho123@MSN-treated multidrug-resistant cells than in free Rho123-exposed counterparts. The exceptional drug-delivery potential of MSNs was further verified using Mitomycin C (MMC)-loaded RhoB@MSNs (RhoB@MMC@MSNs). Exposures to RhoB@MMC@MSNs significantly decreased the viability not only of drug-sensitive but of multidrug-resistant cells and the elimination of MDR cells was significantly more robust than upon free MMC treatments. Conclusion The efficient delivery of Rho123 and MMC to multidrug-resistant cells via MSNs, the amplified and presumably prolonged intracellular drug concentration, and the consequently enhanced cytotoxic effects envision the enormous potential of MSNs to defeat multidrug-resistant cancer.
New Implications of Patients’ Sex in Today’s Lung Cancer Management

Simple Summary We aim to raise awareness that sex is an important factor to take into account in modern-day thoracic oncology practice. Summarized, women should be specifically targeted in smoking cessation campaigns and sex-specific barriers should be addressed. Women present more often with adenocarcinoma histology and EGFR/ALK alterations, as lung cancer in never-smokers is more common in women compared to men. Lung cancer in female patients may show a poorer response to immune checkpoint inhibition; therefore, the addition of chemotherapy should be considered. On the other hand, women experience more benefits from targeted therapy against EGFR. In general, prognosis for women is better compared to that in men. Lung cancer screening trials report that women derive more benefit from screening, although they have not been designed for women. Future trial designs should take this into account and encourage participation of women. Abstract This paper describes where and how sex matters in today’s management of lung cancer. We consecutively describe the differences between males and females in lung cancer demographics; sex-based differences in the immune system (including the poorer outcomes in women who are treated with immunotherapy but no chemotherapy); the presence of oncogenic drivers and the response to targeted therapies according to sex; the greater benefit women derive from lung cancer screening and why they get screened less; and finally, the barriers to smoking cessation that women experience. We conclude that sex is an important but often overlooked factor in modern-day thoracic oncology practice.
Mock juror decisions regarding an undocumented immigrant: Similarity of defendant-juror ethnicity matters

Abstract Hispanic and White undergraduates (N = 238) read an online scenario depicting a Hispanic defendant on trial; defendant documentation status (undocumented, natural-born citizen) and defendant background (more sympathetic, less sympathetic) were varied. White participants saw the Hispanic defendant as generally more likely to commit a crime than Hispanic participants. White participants also saw the undocumented defendant as most likely to be guilty, while Hispanic participants saw the undocumented defendant as least likely to be guilty. These results suggest that defendant-juror similarity has an impact on juror decisions, even when the defendant is undocumented, a finding important for those selecting jurors.
Analysis of factors affecting occupant injury severity in rear-end crashes by different struck vehicle groups: A random thresholds random parameters hierarchical ordered probit model

Abstract This study aims to explore the variability of risk factors affecting injury severity in rear-end crashes when different struck vehicle groups are involved. Two types of rear-end crash data, vehicle-strike-car data, vehicle-strike-truck data, are extracted from the Fatality Analysis Reporting System (FARS). Two likelihood ratio (LR) tests are firstly performed to validate the struck vehicle group variations, and then two separate random thresholds random parameters hierarchical ordered probit (RRHOP) models (Model 1 and Model 2) are established to capture unobserved heterogeneity. The results of LR test show significant differences in the effects of factors included in each model. Moreover, the model results suggest that SUVs, vans, and large trucks as striking vehicles are significant related to injury severity in both models with different effects. Factors such as speeding related, pickup, model year (struck vehicle), disabled damage, adverse weather, speed limit (≥60 mile/h), and young driver (struck vehicle) are found to be statistically significant in only model 1. These results provide a better understanding of differences in contributing factors of rear-end crashes, which help to propose effective countermeasures to mitigate its injury severity.
Immune Checkpoint Inhibitor-Mediated Cancer Theranostics with Radiolabeled Anti-Granzyme B Peptide

Although immune checkpoint inhibitors (ICI) have revolutionized cancer management, patient response can be heterogeneous, and the development of ICI resistance is increasingly reported. Novel treatment strategies are necessary not only to expand the use of ICI to previously unresponsive tumor types but also to overcome resistance. Targeted radionuclide therapy may synergize well with ICIs since it can promote a pro-inflammatory tumor microenvironment. We investigated the use of a granzyme B targeted peptide (GZP) as a cancer theranostic agent, radiolabeled with 68Ga (68Ga-GZP) as a PET imaging agent and radiolabeled with 90Y (90Y-GZP) as a targeted radionuclide therapy agent for combinational therapy with ICI in murine models of colon cancer. Our results demonstrate that GZP increasingly accumulates in tumor tissue after ICI and that the combination of ICI with 90Y-GZP promotes a dose-dependent response, achieving curative response in some settings and increased overall survival.
Employability of distance education graduates of a public university in Ghana

This study examines the employability of Ghanaian graduates who have completed education and business degree programmes through distance education in a public university. A descriptive research design is used, and the study is cross-sectional in nature. The sample of 643 was drawn from 19,832 graduates who had completed business and education programmes between 2014 and 2018, using the simple random sampling technique. Data were collected through a telephone-administered survey with a structured questionnaire. Data were analysed with descriptive and inferential statistics and are presented in tables and figures. The findings indicate that these distance education graduates are employable and possess many employability attributes. The results further show that there are differences in employability attributes among those graduates who studied business and those who studied education, with the business graduates having a higher mean score. The study highlights the factors that the graduates believed would have enhanced their employability. The author concludes that the university management needs to strengthen its collaboration with industrial stakeholders in the design and implementation of curricula.
Open-domain Conversational Agent based on Pre-trained Transformers for Human-Robot Interaction

: Generative pre-trained transformers belong to the breakthroughs in Natural Language Processing (NLP), allowing Human-Robot Interactions ( e.g. the creation of an open-domain chatbot). However, a substantial amount of research and available data are in English, causing low-resourced languages to be overlooked. This work addresses this problem for European Portuguese with two options: (i) Translation of the sentences before and after using the model ﬁne-tuned on an English-based dataset, (ii) Translation of the English-based dataset to Portuguese and then ﬁne-tune this model on it. We rely on the DialoGPT (dialogue generative pre-trained transformer), a tunable neural conversational answer generation model that learns the basic skills to conduct a dialogue. We use two sources of evaluation: (i) Metrics for text generation based on uncertainty ( i.e. perplexity), and similarity between sentences ( i.e. BLEU, METEOR and ROUGE) and (ii) Human-based evaluation of the sentences. The translation of sentences before and after of the modiﬁed DialoGPT model, using the Daily Dialogue dataset led to the best results.
Estimating longitudinal change in latent variable means: a comparison of non-negative matrix factorization and other item non-response methods

ABSTRACT Estimates of longitudinal change in the parameters of latent (i.e. unobserved) variables, including means, are affected by non-response on the items or indicators of the latent variable. This study used Monte Carlo simulation and a numeric example to compare four ordinal item non-response methods: non-negative matrix factorization (NNMF), multiple imputation with conditional proportional odds model (POM), full information maximum likelihood (FIML) and complete-case analysis, when estimating the longitudinal change in latent variable means. The mean squared error for the NNMF method was more than 40% lower than for the FIML and POM methods when the latent variable correlations over time were strong, percentage of missing data was 25% or more, and sample size was large. The NNMF method is a promising method to address item non-response. It is relatively efficient when sample size is large, and the percentage of missing data is high but has limitations under other data-analytic conditions.
Exploring Corporate Reputation based on Sentiment Polarities That Are Related to Opinions in Dutch Online Reviews

: This research demonstrates the power and robustness of the vocabulary method by Hernández-Rubio et al. (2019) for aspect extraction from online review data. We showcase that this algorithm not only works on the English language based on the CoreNLP toolkit, but also extend it on the Dutch language, specifically with aid of the Frog toolkit. Results on sampled datasets for three different retailers show that it can be used to extract fine-grained aspects that are relevant to acquire corporate reputation insights.
The Efficacy of Low-Level Laser Therapy Combined with Single Flap Periodontal Surgery in the Management of Intrabony Periodontal Defects: A Randomized Controlled Trial

This study aimed at assessing the clinical outcomes of the Single Flap Approach (SFA) with the additional use of Low-level laser therapy (LLLT). The defects were treated as per the principles of SFA, whereby 20 defects received only SFA (control group) and 20 defects received additional LLLT for bio stimulation/bio modulation (test group). Stable primary closure of the flaps was obtained with vertical internal mattress sutures. Plaque indices (FMPS), clinical attachment levels (CAL), probing pocket depth (PPD), and gingival bleeding scores (FMBS) were calculated at baseline, and at the 3rd and 6th months in both groups. An EHI score of 1 was observed at all sites except for two, where a score of 2 in the control group at week 2 was observed. In the test group, the PPD reduction at 6 months was 3.60 ± 0.95 and in the control group it was 3.75 ± 0.91 mm. CAL gain at 6 months was 2.70 ± 1.36 mm and 3.45 ± 1.2 mm in the test group and showed no statistical significance. These data suggested the positive effect of LLLT over CAL gain; thus, LLLT may be combined with SFA to potentially enhance the early wound healing and higher clinical outcomes in terms of increase in CAL and decrease in PPD.
Building information modelling in construction: insights from collaboration and change management perspectives

Abstract A case study is used to obtain the experiences from a contractor and their subcontractors involved with constructing the landmark Perth Stadium, which required a building information model (BIM) to be delivered for the purpose of asset management. Insights about ‘how’ the adoption of a BIM influenced the practice of collaboration and change management within the project are obtained. It was revealed that having limited experience and knowledge to deliver a model for asset management often resulted the project team ‘muddling through a problem’. This was not necessarily due to a shortage of training, but a lack of BIM knowledge, which inadvertently influenced every day practice. The research presented builds on the extant body of works that have examined how the construction industry can effectively acquire the benefits of BIM for asset management. It also highlights the need to incorporate education and learning into a project’s BIM implementation strategy.
Vine Age Affects Vine Performance, Grape and Wine Chemical and Sensory Composition of cv. Zinfandel from California

The wine industry regards old vines as nonpareil because of the vine’s decreased capacity to set and mature fruit, which results in superior wine quality. Here we report the viticultural, chemical, and sensory effects of vine age in Vitis vinifera L. cv. Zinfandel. Three treatments, Young vines (five to 12 years old), Control (representative proportion of young to old vines in the block), and Old vines (40 to 60 years old) were established at an interplanted, dry farmed, Zinfandel vineyard block under consistent, industry standard, management practices in California over two consecutive vintages. Old vines produced, on average, 3.7 kg more fruit and more clusters per vine than Young vines (13.37 tons/ha and 6.52 tons/ha, respectively). While no differences in root distribution or architecture were found, Old vines displayed greater rooting depths (1.52 to 1.73 + m) than Young vines (1.40 to 1.52 + m). Wines from Young vines had lower pH, titratable acidity, and tannins than wines from Old vines, which in turn displayed a wider array and intensity of more complex aromas relative to Young vine wines. Overall, it is concluded that there is a potential for greater yield, rooting depths, and wine quality when extending the longevity of Zinfandel vineyards. These findings support maintaining old vine vineyards to increase tonnage without sacrificing wine quality.
Vocational education: a poor second choice? A comparison of the labour market outcomes of academic and vocational graduates in China

ABSTRACT In the Reform Era, the Chinese Government has placed great emphasis on the role of education in ensuring the economic success of individuals and of the country as a whole. While vocational and academic post-secondary qualifications are officially set at the same level, vocational education is positioned at the bottom of the educational hierarchy and suffers considerable societal prejudice. Drawing on the most recent nationwide-representative data, we investigate the labour market positioning of graduates from the two types of education in terms of their income, occupation, and level of employment precariousness. The results suggest that: (1) vocational graduates earn less than academic graduates; (2) the type of post-secondary education is significantly correlated with the likelihood of obtaining white-collar high-skilled positions; and (3) vocational graduates face greater precariousness in their jobs than academic graduates do. This study also reveals that the hierarchically stratified post-secondary system may be a source of economic inequality in the Chinese Reform Era. Moreover, it demonstrates that the visible hand of the state seems to further facilitate the reproduction of current forms of inequality that leave an increasing number of graduates in marginalised labour market positions.
Convergence of a Piggyback-Style Method for the Differentiation of Solutions of Standard Saddle-Point Problems

We analyse a “piggyback”-style method for computing the derivative of a loss which depends on the solution of a convex-concave saddle point problems, with respect to the bilinear term. We attempt to derive guarantees for the algorithm under minimal regularity assumption on the functions. Our ﬁnal convergence results include possibly nonsmooth objectives. We illustrate the versatility of the proposed piggyback algorithm by learning optimized shearlet transforms, which are a class of popu-lar sparsifying transforms in the ﬁeld of imaging.
Gait Analysis in Children with Cerebral Palsy: Are Plantar Pressure Insoles a Reliable Tool?

Cerebral palsy (CP) is a common cause of motor disability, and pedobarography is a useful, non-invasive, portable, and accessible tool; is easy to use in a clinical setting; and can provide plenty of information about foot–soil interaction and gait deviations. The reliability of this method in children with CP is lacking. The aim of this study is to investigate test–retest reliability and minimal detectable change (MDC) of plantar pressure insole variables in children with CP. Eight children performed two trials 8 ± 2.5 days apart, using foot insoles to collect plantar pressure data. Whole and segmented foot measurements were analyzed using intraclass correlation coefficients (ICC). The variability of the data was measured by calculating the standard error of measurement (SEM) and the MDC/ICC values demonstrated high test–retest reliability for most variables, ranging from good to excellent (ICC ≥ 0.60). The SEM and the MDC values were considered low for the different variables. The variability observed between sessions may be attributed to the heterogeneous sub-diagnosis of CP.
Diabetic Amyotrophy (Bruns-Garland Syndrome): A Narrative Review

Background and Aims: Bruns-Garland syndrome (BGS) continues to be a contentious topic even 100 years after its discovery. Its lifelong incidence is 1% amongst diabetic individuals and affects middle aged-elderly individuals with type 2 diabetes mellitus (usually not poorly controlled). Methods: The data presented in this review was collated from studies published on PubMed, MEDLINE and Google Scholar in October 2021. The search words included: “Bruns-Garland syndrome”, “diabetic amyotrophy” and “diabetic lumbosacral radiculoplexus neuropathy” and “proximal diabetic neuropathy”. Results: The exact pathophysiology is debatable but an ischemic pathology (non-systemic microvasculitis) is most plausible. Its cardinal symptoms include acute onset of severe proximal lower extremity pain followed by weakness and wasting, some sensory loss, weight loss and autonomic symptoms. Conclusion: The prognosis is good as most patients improve to near- normal strength with pain cessation within 18 months of onset.
Unprincipled and unrealised: CEDAW and discrimination experienced in the context of migration control

This article analyses the CEDAW Committee’s General Recommendations and Views on individual complaints, to evaluate its contribution to the elimination of discrimination against women experienced in the context of migration control. It makes two arguments. First, the Committee’s General Recommendations contain a range of doctrinal and empirical shortcomings. This opacity, and these omissions, considerably reduce the value of the Committee’s statements as a means by which States’ discriminatory migration control practices might be contested. Second, the Committee’s decisions, in communications concerned with discrimination experienced in the context of migration control, are inconsistent with those standards that it has set, and with the decisions it makes in other types of cases. A detailed analysis of the jurisprudence grounds the conclusion that the Committee is, in practice, according States a margin of appreciation that varies according to the subject of the complaint. Particular, representative communications are drawn on to argue that the margin granted in cases concerned with migration control is over-wide, characteristic not of appropriate (quasi) judicial restraint, but unprincipled deference. The article concludes by suggesting how some of the criticisms outlined may be remedied, notably by the Committee adopting its own justification and proportionality assessment.