Miracle-dz/UniFAR-FTUs huggingface dataset:
The influence of achievement goals on objective driving behavior

Investigating psychological characteristics through self-reported measures (e.g., anger, sensation seeking) and dynamic behaviors through objective measures (e.g., speed, 2D acceleration, GPS position etc.) may allow us to better understand the behavior of at-risk drivers. To assess drivers’ motivation, the theoretical framework of achievement goals has been studied recently. These achievement goals can influence the decision-making and behaviors of individuals engaged in driving. The four achievement goals in driving are: seeking to improve or to drive as well as possible (mastery-approach), to outperform other drivers (performance-approach), to avoid driving badly (mastery-avoidance), and to avoid being the worst driver (performance-avoidance). Naturalistic Driving Studies (NDS) provide access to the objective measurements of data not accessible through self-reported measurements (i.e., speed, accelerations, GPS position). Three dynamic criteria have been developed to characterize the behavior of motorists objectively: driving events, time spent above acceleration thresholds (longitudinal and transversal), and the extent of dynamic demands. All these criteria have been measured in different road contexts (e.g., plain). The aim of this study was to examine the predictive role of the four achievement goals on these objective driving behaviors. 266 drivers (96 women, 117 men) took part in the study, and 4 242 482 km was recorded during 8 months. Simultaneously, they completed the Achievement Goals in Driving Questionnaire. The main results highlighted that mastery-approach goals negatively predicted hard braking and the extent of dynamic demands on plain and hilly roads. Mastery-approach goals seem to be the most protective goals in driving. Future research on the promotion of mastery-approach goals in driving may be able to modify the behavior of at-risk drivers.
Charge-trapping memory cell of SiO2∕SiN∕high‐k dielectric Al2O3 with TaN metal gate for suppressing backward-tunneling effect

We present a device structure of SiO2∕SiN∕Al2O3 (SANOS) with tantalum nitride (TaN) metal gate. When TaN metal gate is applied for the SANOS structure instead of commonly used n-type poly-silicon, the unwanted backward Fowler–Nordheim tunneling current of electron through the top oxide is significantly suppressed owing to its higher work function and better compatibility with high-k dielectrics. As a result, the program∕erase speed is significantly improved and the erase threshold voltage (VTH) can be obtained to be negative voltage of −3.5V.
Understanding key behavioral factors affecting road traffic citation and crash involvement of professional bus and passenger van drivers using a modified driver behavior questionnaire: an Indian perspective

A customized 27-item driver behavior questionnaire (DBQ) for professional long-distance bus and passenger van drivers in Bihar, India was tested separately and the underlying factor structures identified. In total, 156 bus and 149 passenger van drivers were surveyed and their self-reported aberrations, measured using the DBQ, were recorded along with their self-reported traffic citation and crash involvement in the past 3 years. A 21-item seven-factor DBQ and a 19-item five-factor DBQ were obtained for bus and passenger van drivers respectively through exploratory and confirmatory factor analysis. Structural equation modeling was used to find relations between DBQ factors and drivers’ number of crashes and traffic citations involvements. Only speed issues could significantly explain traffic citation involvement but no factor could significantly explain crash involvement for bus drivers. For passenger van drivers, only aggressive violations could explain traffic citation involvement while unmindfulness, aggressive violations and errors could explain crash involvement.
Seroprevalence, correlates and kinetics of SARS-CoV-2 nucleocapsid IgG antibody in healthcare workers and nonclinical staff at a tertiary hospital: A prevaccine census study

Background Healthcare workers and nonclinical staff in medical facilities are perceived to be a high-risk group for acquiring SAR-CoV-2 infection, and more so in countries where COVID-19 vaccination uptake is low. Serosurveillance may best determine the true extent of SARS-CoV-2 infection since most infected HCWs and other staff may be asymptomatic or present with only mild symptoms. Over time, determining the true extent of SARS-CoV-2 infection could inform hospital management and staff whether the preventive measures instituted are effective and valuable in developing targeted solutions. Methods This was a census survey study conducted at the Aga Khan University Hospital, Nairobi, between November 2020 and February 2021 before the implementation of the COVID-19 vaccination. The SARS-CoV-2 nucleocapsid IgG test was performed using a chemiluminescent assay. Results One thousand six hundred thirty-one (1631) staff enrolled, totalling 60% of the workforce. The overall crude seroprevalence was 18.4% and the adjusted value (for assay sensitivity of 86%) was 21.4% (95% CI; 19.2–23.7). The staff categories with higher prevalence included pharmacy (25.6%), outreach (24%), hospital- based nursing (22.2%) and catering staff (22.6%). Independent predictors of a positive IgG result after adjusting for age, sex and comorbidities included prior COVID-19 like symptoms, odds ratio (OR) 2.0 [95% confidence interval (CI) 1.3–3.0, p = 0.001], a prior positive SARS-CoV-2 PCR result OR 12.0 (CI: 7.7–18.7, p<0.001) and working in a clinical COVID-19 designated area, OR 1.9 (CI 1.1–3.3, p = 0.021). The odds of testing positive for IgG after a positive PCR test were lowest if the antibody test was performed more than 2 months later; OR 0.7 (CI: 0.48–0.95, p = 0.025). Conclusions The prevalence of anti- SARS-CoV-2 nucleocapsid IgG among HCWs and nonclinical staff was lower than in the general population. Staff working in clinical areas were not at increased risk when compared to staff working in non-clinical areas.
Informal caregiver motivations, values, challenges and gains: A photovoice and interpretative phenomenological analysis of interrelationships

The adoption of a caregiving role in the context of illness and disability is often taken for granted. This study explores caregivers’ motivations to provide care and how these relate to values, and to the challenges and gains of caregiving. Eight semi-structured interviews were conducted with caregivers and photographs were taken by caregivers to exemplify their caregiving experiences. This photo-elicitation method complemented the use of Interpretative Phenomenological Analysis when applied to verbatim transcripts. Superordinate themes included: caregiver’s life story; significance of family; caregiving obligations; caring relationship; challenges and gains associated with caregiver motivations. Intrinsic and extrinsic motivations were less distinct in caregivers’ lived experiences than previously suggested, and were influenced by family values and specific challenges and gains of caregiving. The coexistence of different motivations and the nature of single complex motivations is discussed. The importance of caregiver assessment and support planning, and regular breaks from caregiving are highlighted.
Human Adipose- and Amnion-Derived Mesenchymal Stromal Cells Similarly Mitigate Osteoarthritis Progression in the Dunkin Hartley Guinea Pig

Background: Clinical trials are currently underway to investigate the efficacy of intra-articular administration of mesenchymal stromal cells (MSCs) to mitigate osteoarthritis (OA) progression in the knee. Although multiple MSC sources exist, studies have yet to determine whether differences in therapeutic efficacy exist between them. Purpose: To compare the ability of intra-articularly injected adipose-derived MSCs (AD-MSCs) and amnion-derived MSCs (AM-MSCs) to mitigate the progression of knee OA in a small animal model of spontaneous OA, as well as to compare the therapeutic potential of MSCs in hyaluronic acid (HA) and in HA only with saline (OA) controls. Study Design: Controlled laboratory study. Methods: Injections of AD-MSCs or AM-MSCs suspended in HA or HA only were performed in the rear stifle joints of 3-month-old Dunkin Hartley guinea pigs (DHGPs). Repeat injections occurred at 2 and 4 months after the initial injection in each animal. Contralateral limbs received saline injections and served as untreated controls. Subsequently, joints were analyzed for osteoarthritic changes of the cartilage and subchondral bone via histologic and biochemical analyses. To evaluate MSC retention time in the joint space, DHGPs received a single intra-articular injection of fluorescently labeled AD-MSCs or AM-MSCs, and the fluorescence intensity was longitudinally tracked via an in vivo imaging system. Results: No statistically significant differences in outcomes were found when comparing the ability of AD-MSCs and AM-MSCs to mitigate OA. However, the injection of AD-MSCs, AM-MSCs, and HA-only treatments more effectively mitigated cartilage damage compared with that of saline controls by demonstrating higher amounts of cartilage glycosaminoglycan content and improved histological proteoglycan scoring while reducing the percentage of osteophytes present. Conclusion: Intra-articular injection of AD-MSCs, AM-MSCs, or HA only was able to similarly mitigate the progression of cartilage damage and reduce the percentage of osteophytes compared with that of saline controls in the DHGP. However, this study was unable to establish the superiority of AD-MSCs versus AM-MSCs as a treatment to mitigate spontaneous OA. Clinical Relevance: MSCs demonstrate the ability to mitigate the progression of knee OA and thus may be used in a prophylactic approach to delay the need for end-stage treatment strategies.
Unpacking the Tibial Tubercle–Trochlear Groove Distance: Evaluation of Rotational Factors, Trochlear Groove and Tibial Tubercle Position, and Role of Trochlear Dysplasia

Background: The tibial tubercle to trochlear groove (TT-TG) distance is often utilized for determining the surgical treatment for patients with patellar instability (PI). It is thought to directly represent the position of the TT on the tibia. Recent work has shown that the measurement of the TT-TG distance is multifactorial. Purpose: To investigate the relationship between relative tibial external rotation (rTER) and trochlear dysplasia (TD), as well as the location of the TG and TT in patients with and without PI, and to correlate these and other anatomic measurements with the TT-TG distance. Study Design: Cross-sectional study; Level of evidence, 3. Methods: A total of 89 patients with PI who underwent magnetic resonance imaging were identified with 92 matched control patients. A standardized measurement protocol on axial magnetic resonance imaging determined rTER, the proximal and distal TG lateralization (pTGL and dTGL, respectively) ratios, and the TT lateralization (TTL) ratio. Other measures of interest included the lateral trochlear inclination angle, sulcus angle, and lateral patellar inclination angle. Univariate regression was used to determine the associations of TD (lateral trochlear inclination angle, sulcus angle) with rTER and the TG position, and multivariate regression was used to model associations among all the variables with the proximal and distal TT-TG distances. Results: rTER was significantly higher in the study group (P < .001), and univariate regression showed a significant association between dysplasia measures and rTER (P < .001). The pTGL ratio was lower in the study group (P = .025), but there was no difference in the dTGL ratio (P = .090) or the TTL ratio (P = .098) between the groups. There were no associations between dysplasia measures and the pTGL and dTGL ratios (P > .05). Multivariate regression showed that the proximal TT-TG distance is predicted by the sulcus angle, pTGL ratio, rTER, and TTL ratio (P < .05) and that the distal TT-TG distance is predicted by the lateral patellar inclination angle, dTGL ratio, sulcus angle, rTER, and TTL ratio (P < .05). Conclusion: rTER had a significant association with TD. The position of the proximal TG was more medial in patients with PI. There was no significant difference in the TTL ratio between patients with and without PI. The TT-TG distance was associated with multiple anatomic measures and was not solely predicated on the position of the TT.
A thermostat for molecular dynamics of complex fluids

A thermostat of the Nosé–Hoover type, based on relative velocities and a local definition of the temperature, is presented. The thermostat is momentum-conserving and Galilean-invariant, which should make it suitable for use in Dissipative Particle Dynamics (DPD) simulations, as well as nonequilibrium molecular dynamics simulations.
Pinned Wigner crystals

We study the effects of weak disorder on a Wigner crystal in a magnetic field. We show that an elastic description of the pinned Wigner crystal provides an excellent framework to obtain most of the physically relevant observables. Using such a description, we compute the static and dynamical properties. We find that, akin to the Bragg glass phase, a good degree of translational order survives (up to a large length scale in d = 2, infinite in d = 3) ). Using a Gaussian variational method, we obtain the full frequency dependence of the conductivity tensor. The zero temperature Hall resistivity is independent of frequency and remains unaffected by disorder at its classical value. We show that the characteristic features of the conductivity in the pinned Wigner crystal are dramatically different from those arising from the naive extrapolations of Fukuyama-Lee-type theories for charge density waves. We determine the relevant scales and find that the physical properties depend crucially on whether the disorder correlation length is larger than the cyclotron length or not. We analyze, in particular, the magnetic field and density dependence of the optical conductivity, Within our approach the pinning frequency can increase with increasing magnetic field and varies as n - 3 / 2 with the density n. We compare our predictions with recent experiments on transport in two-dimensional electron gases under strong magnetic fields. Our theory allows for a consistent qualitative interpretation of these experiments in terms of a pinned WC.
Resonant Absorption of Surface Sausage and Surface Kink Modes under Photospheric Conditions

We study the effect of resonant absorption of surface sausage and surface kink modes under photospheric conditions where the slow surface sausage modes undergo resonant damping in the slow continuum and the surface kink modes in the slow and Alfvén continua at the transitional layers. We use recently derived analytical formulas to obtain the damping rate (time). By considering linear density and linear pressure profiles for the transitional layers, we show that resonant absorption in the slow continuum could be an efficient mechanism for the wave damping of the slow surface sausage and slow surface kink modes while the damping rate of the slow surface kink mode in the Alfvén continuum is weak. It is also found that the resonant damping of the fast surface kink mode is much stronger than that of the slow surface kink mode, showing a similar efficiency as under coronal conditions. It is worth noting that the slow body sausage and kink modes can also resonantly damp in the slow continuum for those linear profiles.
Improved Dynamical Constraints on the Masses of the Central Black Holes in Nearby Low-mass Early-type Galactic Nuclei and the First Black Hole Determination for NGC 205

We improve the dynamical black hole (BH) mass estimates in three nearby low-mass early-type galaxies: NGC 205, NGC 5102, and NGC 5206. We use new Hubble Space Telescope (HST)/STIS spectroscopy to fit the star formation histories of the nuclei in these galaxies, and use these measurements to create local color–mass-to-light ratio (M/L) relations. We then create new mass models from HST imaging and combined with adaptive optics kinematics, we use Jeans dynamical models to constrain their BH masses. The masses of the central BHs in NGC 5102 and NGC 5206 are both below one million solar masses and are consistent with our previous estimates, M⊙ and M⊙ (3σ errors), respectively. However, for NGC 205, the improved models suggest the presence of a BH for the first time, with a best-fit mass of M⊙ (3σ errors). This is the least massive central BH mass in a galaxy detected using any method. We discuss the possible systematic errors of this measurement in detail. Using this BH mass, the existing upper limits of both X-ray, and radio emissions in the nucleus of NGC 205 suggest an accretion rate ≲10−5 of the Eddington rate. We also discuss the color–M/Leff relations in our nuclei and find that the slopes of these vary significantly between nuclei. Nuclei with significant young stellar populations have steeper color–M/Leff relations than some previously published galaxy color–M/Leff relations.
The PaCO2/FiO2 ratio as outcome predictor in SARS-COV-2 related pneumonia: a retrospective study

Background and aim: Respiratory failure in SARS-CoV-2 patients is characterized by the presence of hypoxemia and hypocapnia without relevant dyspnea. To date, the use of respiratory parameters other than PaO2/FiO2 ratio to stratify the risk of worsening of these patients has not been sufficiently studied. Aim of this work was to evaluate whether the ratio between partial pressure levels of carbon dioxide (PaCO2) and the fraction of inspired oxygen (FiO2) measured at emergency department (ED) admission is predictive of the clinical course of patients suffering from SARS-CoV-2 pneumonia. Methods: We retrospectively studied 236 patients with SARS-CoV-2 pneumonia evaluated at the ED of the Perugia Hospital. The end-points were: in-hospital mortality, need for invasive mechanical ventilation (IMV) and length of in-hospital stay (LOS). Clinical, blood gas and laboratory data were collected at ED admission. Results: Of the 236 patients 157 were male, the mean age was 64 ± 16. Thirtythree patients (14%) needed IMV, 49 died (21%). In the univariate analysis, the PaCO2/FiO2 ratio was inversely associated with the need for IMV (p <0.001), mortality (p <0.001) and LOS (p = 0.005). At the multivariate analysis the PaCO2/FiO2 ratio was found to be predictive of the need for IMV, independently from age, gender, number of comorbidities, neutrophils, lymphocytes, glomerular filtrate, d-dimer, LDH and CRP. Conclusions: the PaCO2/FiO2 ratio is predictive of the risk of respiratory failure worsening in patients with SARS-CoV-2 pneumonia, independently from other several confounding factors. (www.actabiomedica.it)
CUSUM Monitoring of First-Order Integer-Valued Autoregressive Processes of Poisson Counts

Attributes control charts for counts generally assume that the process being monitored is independent and identically distributed in its in-control state. However, violation of this assumption in practice may significantly degrade a chart's performance and usefulness if the autocorrelation structure is not taken into account. To describe the autocorrelation structure of counts in an in-control process, integer-valued autoregressive moving average process models can be employed. This paper investigates the cumulative sum (CUSUM) control chart for monitoring autocorrelated processes of counts modeled by a Poisson integer-valued autoregressive model of order 1, namely Poisson INAR(1). The CUSUM chart is designed to detect assignable causes affecting the process mean, but also changes in the autocorrelation structure are considered. Exact numerical results obtained through a bivariate Markov chain approach are provided for sustained shifts in any or both of these process parameters. Some numerical results from a simulation study of the residuals' monitoring are also presented. It is shown that the considered CUSUM chart of observations has good overall performance in detecting assignable causes in autocorrelated count processes.
Dual‐phase 18F‐FP‐CIT positron emission tomography and cardiac 123I‐MIBG scintigraphy of Parkinson's disease patients with GBA mutations: evidence of the body‐first type?

Parkinson's disease (PD) with glucocerebrosidase (GBA) gene mutation (GBA‐PD) is known to show more rapid clinical progression than sporadic PD without GBA mutation (sPD). This study was performed to delineate the specific patterns of cortical hypoperfusion, dopamine transporter uptake and cardiac meta‐iodobenzylguanidine (MIBG) uptake of GBA‐PD in comparison to sPD.
The impact of exercise training on endothelial function in postmenopausal women: a systematic review

What is the topic of this review? The aim of this systematic review was to evaluate and summarize all published literature examining the impact of various exercise training interventions on endothelial function in postmenopausal women. What advances does it highlight? There was a moderate effect of training on macrovascular and microvascular endothelial function and just under two‐thirds of studies demonstrated a significant increase in at least one measure of endothelial function in postmenopausal women. Factors including exercise intensity and duration, vessel type, clinical status, hormone therapy, and menopausal status may influence the effects of training on endothelial function in postmenopausal women.
Functional profile of host microbiome indicates Clostridioides difficile infection

ABSTRACT Clostridioides difficile infection (CDI) is a gastro-intestinal (GI) infection that illustrates how perturbations in symbiotic host–microbiome interactions render the GI tract vulnerable to the opportunistic pathogens. CDI also serves as an example of how such perturbations could be reversed via gut microbiota modulation mechanisms, especially fecal microbiota transplantation (FMT). However, microbiome-mediated diagnosis of CDI remains understudied. Here, we evaluated the diagnostic capabilities of the fecal microbiome on the prediction of CDI. We used the metagenomic sequencing data from ten previous studies, encompassing those acquired from CDI patients treated by FMT, CDI-negative patients presenting other intestinal health conditions, and healthy volunteers taking antibiotics. We designed a hybrid species/function profiling approach that determines the abundances of microbial species in the community contributing to its functional profile. These functionally informed taxonomic profiles were then used for classification of the microbial samples. We used logistic regression (LR) models using these features, which showed high prediction accuracy (with an average $$AUC \ge 0.91$$AUC≥0.91), substantiating that the species/function composition of the gut microbiome has a robust diagnostic prediction of CDI. We further assessed the confounding impact of antibiotic therapy on CDI prediction and found that it is distinguishable from the CDI impact. Finally, we devised a log-odds score computed from the output of the LR models to quantify the likelihood of CDI in a gut microbiome sample and applied it to evaluating the effectiveness of FMT based on post-FMT microbiome samples. The results showed that the gut microbiome of patients exhibited a gradual but steady improvement after receiving successful FMT, indicating the restoration of the normal microbiome functions.