Miracle-dz/UniFAR-FTUs huggingface dataset:
The Impact of Core Tissues on Successful Next-Generation Sequencing Analysis of Specimens Obtained through Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration

Simple Summary Next-generation sequencing (NGS) with specimens obtained through endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) has been used to identify cancer-related genes among patients with lung cancer. However, the reported success rates vary, and the clinical factors associated with successful NGS remain unclear. We retrospectively reviewed consecutive patients with non-small-cell lung cancer who underwent EBUS-TBNA for NGS (OncomineTM Dx Target Test). The numbers of punctures and core tissues, as well as computed tomography (CT) and EBUS findings, were evaluated. The success rate of NGS was 83.3% (130/156). The cut-off value for the number of core tissues was 4, and the sensitivity and specificity for successful NGS were 73.8% and 61.5%, respectively. CT and EBUS findings were not associated with successful NGS. In logistic regression analysis, the number of core tissues (≥4) was the sole predictor of successful NGS. Bronchoscopists should obtain sufficient core tissues for successful NGS using EBUS-TBNA specimens. Abstract The success rate of next-generation sequencing (NGS) with specimens obtained through endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) among patients with lung cancer as well as the related clinical factors remain unclear. We aimed to determine the optimal number of punctures and core tissues during EBUS-TBNA for NGS in patients with non-small-cell lung cancer (NSCLC) as well as the association of chest computed tomography (CT) and EBUS findings with successful NGS. We retrospectively reviewed 156 consecutive patients with NSCLC who underwent EBUS-TBNA for NGS (OncomineTM Dx Target Test). Using the receiver operating characteristic curve, we calculated the optimal numbers of punctures and core tissues for NGS and evaluated CT and EBUS findings suggestive of necrosis and vascular pattern within the lesion. The success rate of NGS was 83.3%. The cut-off value for the number of core tissues was 4, and the sensitivity and specificity of successful NGS were 73.8% and 61.5%, respectively. Logistic regression analysis revealed that the number of core tissues (≥4) was the sole predictor of successful NGS. CT and EBUS findings were not associated with successful NGS. Bronchoscopists should obtain sufficient core tissues for successful NGS using EBUS-TBNA specimens.
Reconnaissance Report of Chilean Industrial Facilities Affected by the 2010 Chile Offshore Bío-Bío Earthquake

This paper summarizes findings of an EERI reconnaissance team and a group of Chilean experts on damage to industrial facilities caused by the 27 February 2010 Offshore Bío-Bío Earthquake and ensuing tsunami. Chile's industry as a whole was severely affected when major industrial plants such as paper mills, wood mills, thermoelectric power plants, and oil and gas refineries were shut down following the earthquake either in response to the damage sustained or to maintain structural and environmental safety. Damage resulted primarily from ground shaking; however, it was exacerbated by the ensuing tsunami in coastal areas. Important industrial sectors, such as the wine industry and fishing, pulp and paper industries, suffered severely. Observed damage was primarily due to inadequate anchorage of equipment, differential movements between adjacent supports of piping and equipment, foundation displacements, and failure of non-structural elements and equipment.
Assessment of success factors for joint venture construction projects in Nigeria

Purpose – The increasing pressure from clients and global construction trends have led the construction industry to seek better options for overcoming the emerging challenges and critical issues battling construction projects. The purpose of this paper is to assess the factors affecting the performance of partners in joint ventures construction projects in Nigeria.Design/methodology/approach – Primary data were collected through the administration of questionnaire to partners and consultants who have engaged in joint venture construction project in partnership with the Lagos State Development and Property Corporation. The data obtained were analyzed using Mean Item Score, Wilcoxon‐Mann‐Whitney (U‐test) test, Kruskal‐Wallis (H‐test) test and factor analysis.Findings – The study revealed that all the factors identified were significant to the performance of partners in joint venture construction with communication, compatibility of objectives and mutual understanding among partners ranked as the most import.
The Pattern of Hybrid Learning to Maintain Learning Effectiveness at the Higher Education Level Post-COVID-19 Pandemic

Online learning during the Coronavirus disease (COVID-19) pandemic has awakened and affirmed the necessity of learning based on digital technology. The article was aimed to analyze the effectiveness of online learning at bachelor’s, master’s, and doctoral degrees of Islamic Religious Education as a reference to develop a learning pattern post-COVID-19 pandemic. The research employed a mixed-method design with a concurrent triangulation model. The samples were taken using stratified random and purposive sampling. Meanwhile, the data were collected through questionnaires, in-depth interviews, and forum group discussion. A descriptive analysis and one-way analysis of variance were used to analyze the quantitative data, while interpretative descriptive for the qualitative data. The research showed that online learning during the COVID-19 pandemic at the bachelor’s, master’s, and doctoral degrees of Islamic Religious Education have been effective. In detail, online learning at the doctoral degree was the most effective among all. On the other hand, face-to-face learning is still necessary. Therefore, the learning pattern developed post-COVID-19 pandemic combines face-to-face and online learning (hybrid learning). The formulation is adjusted to the characteristics, educational purpose and orientation, level of ability, readiness, and learning autonomy of the students at each educational level.
The Increasing Importance of Environmental, Social and Governance (ESG) Investing in Combating Climate Change

The current climate change is significantly caused by anthropogenic greenhouse gases, particularly CO2 released by burning of fossil fuels. Climate change is predicted to disrupt production systems and supply chains of businesses, potentially affecting their financial performance. ESG investing, the consideration of environmental, social and governance factors by asset managers will likely play a crucial role in combating climate change. To attract ESG funds, companies will have to reduce their carbon footprint, among other actions. When companies reduce scope emissions, they help achieve a goal of the Paris Agreement of limiting average global temperature increase to below 2°C above pre-industrial level. The aim is to identify factors that are likely to increase uptake of ESG investing. The increase in number of ESG investors and their assets, higher financial performance of ESG-linked investments, and increasing regulatory and investor initiatives are likely to increase the impact of ESG investing in reducing greenhouse gas emissions. In addition, investors are becoming more environmentally conscious when making investment decisions. Although some challenges persist, including inconsistency in terminology, huge amount of data to analyze and heterogenous rating standards, ESG investing is likely to play an important role in influencing entities to reduce their carbon footprint.
Design and Evaluation of an Athletic Training Educational Escape Room

The educational escape room is an innovative teaching strategy, and the use of this technique is gaining popularity in some health care disciplines. It is believed to promote acquisition of knowledge and skills, increase motivation, and encourage engagement, critical thinking, collaboration, and problem-solving. To describe the use of an innovative educational escape room in a master's-level athletic training course and to examine learning effectiveness and students' perceptions. Quasi-experimental. A Commission on Accreditation of Athletic Training Education–accredited master's-level athletic training program. A convenience sample of 14 students enrolled in a master's-level professional athletic training program participated. Educational escape room. A paired-samples t test was used to determine differences between preactivity and postactivity knowledge-assessment scores. Measures of central tendency were used for survey questions related to student perceptions of the activity. Student perceptions were assessed after the intervention. All participants completed the preactivity and postactivity knowledge assessments. The difference in scores was found to be statistically significant (t13 = −4.502, P = .001), with a large effect size (Cohen d = 1.32). Participants thought the escape room was an effective way to improve their knowledge of course materials (mean ± SD = 5.0 ± 0.0) and encouraged them to apply course material in a new way (mean ± SD = 4.9 ± 0.27). Participants reported that they had fun (mean ± SD = 5.0 ± 0.0) and felt that the activity was immersive (mean ± SD = 5.0 ± 0.00). Qualitative elements from the postactivity survey corroborated the data. The education escape room described in this study promoted learning while providing a fun and engaging learning experience with positive perceived value.
A model comparison of fire return interval impacts on carbon and species dynamics in a southeastern U.S. pineland

A model comparison of ﬁ re interval impacts on carbon and dynamics in a Abstract. Ecosystem process models can be used to predict forest response to disturbances at a range of scales. Selection of the spatial class of model should depend on the scale of the research or management question, and model type should depend on the ecosystem attributes of interest. In some cases, multiple classes of models could be used to address a single research question, with evaluations at each scale having potential bene ﬁ ts and drawbacks. This study examines two classes of models relative to how ﬁ re return intervals impact carbon and species dynamics in a southeastern U.S. pineland. A model that can be run as a global class model (ED) and a landscape class model (LANDIS-II) were parameterized with species inventory data from an experimental Pinus Palustris (longleaf pine) forest in southwest Georgia, and simulations were calibrated with literature values, then validated with eddy-covariance data from the study site. A variety of ﬁ re scenarios that included prescribed ﬁ re with a 2-yr return interval, ﬁ re exclusion, and three wild ﬁ re scenarios (20-, 50-, and 100-yr return intervals) were used for model runs. Results were compared and evaluated with regard to ecosystem carbon and species dynamics. Both models illustrated that prescribed ﬁ re provided the greatest carbon sequestration potential and most stable aboveground biomass through time when compared to the wild- ﬁ re scenarios. The ﬁ re exclusion scenario for LANDIS-II was the only scenario where prescribed ﬁ re did not provide the greatest carbon sequestration potential. However, ﬁ re exclusion on the order of centuries was a condition of this outcome and the occurrence of such long ﬁ re-free periods is considered unrealistic in this ﬁ re-prone landscape. Differences between models were primarily the result of the underlying characteristics of each model class, namely the spatial resolution and number of species included. In the end, two vastly different scale models supported the conclusion that high frequency prescribed ﬁ re in southeastern U.S. pine-lands stabilizes carbon and maintains species composition in an ecosystem that is a known ecological hotspot.
Spatial study of the wake meandering using modelled wind turbines in a wind tunnel

The present paper presents a study of the wake meandering phenomenon with the help of physical modelling in atmospheric boundary layer (ABL) wind tunnel. The wind turbine is modelled at a geometric scale of 1:400 with a static porous disk (actuator disk concept). The main objective of the present work was to supply quantitative information on the meandering process. The instantaneous wake width and its horizontal and vertical swerves from the mean wake axis are quantified using specific image processing of instantaneous velocity fields obtained by particle image velocimetry downstream of the modelled wind turbine. We observe that the wind turbine wake displacements from the mean streamwise axis are very important when the turbulence length scales are larger than the wake width. We also observe that, in ABL conditions, horizontal displacements are higher than the vertical ones with a proportion in agreement with the ratio between the transverse and vertical turbulence intensities σv∕σw ≈ 3∕2. It is finally concluded that the instantaneous wake width remained nearly constant downstream of the wind turbine model whatever the flow conditions and that the extent of the mean wind turbine wake is dominantly due to the meandering process. This confirms that it is necessary to include the meandering process in the wake analysis in order to estimate the fatigue loading on wind turbines within wind farms properly. Copyright © 2011 John Wiley & Sons, Ltd.
Construction and Evaluation of a High-Frequency Hearing Loss Screening Tool for Community Residents

Early screening and detection of individuals at high risk of high-frequency hearing loss and identification of risk factors are critical to reduce the prevalence at community level. However, unlike those for individuals facing occupational auditory hazards, a limited number of hearing loss screening models have been developed for community residents. Therefore, this study used lasso regression with 10-fold cross-validation for feature selection and model construction on 38 questionnaire-based variables of 4010 subjects and applied the model to training and testing cohorts to obtain a risk score. The model achieved an area under the curve (AUC) of 0.844 in the model validation stage and individuals’ risk scores were subsequently stratified into low-, medium-, and high-risk categories. A total of 92.79% (1094/1179) of subjects in the high-risk category were confirmed to have hearing loss by audiometry test, which was 3.7 times higher than that in the low-risk group (25.18%, 457/1815). Half of the key indicators were related to modifiable contexts, and they were identified as significantly associated with the incident hearing loss. These results demonstrated that the developed model would be feasible to identify residents at high risk of hearing loss via regular community-level health examinations and detecting individualized risk factors, and eventually provide precision interventions.
Meningkatkan Kemampuan Berbahasa Lisan pada Anak Usia Dini Melalui Media Gambar Berseri

Kemampuan berkomunikasi secara lisan merupakan hal penting yang harus diajarkan sejak dini. Namun, permasalahan di lapangan menunjukkan bahwa kemampuan berbahasa lisan anak-anak masih sangat kurang dan media pembelajaran yang dapat digunakan untuk meningkatkan kemampuan berbahasa secara lisan belum pernah dikembangkan apalagi diterapkan. Oleh karena itu, penelitian ini bertujuan untuk menganalisis bagaimana pengembangan media gambar berseri untuk meningkatkan kemampuan berbahasa lisan anak kelompok B taman kanak-kanak. Penelitian ini menggunakan metode penelitian pengembangan model ADDIE, yang pada pelaksanaannya hanya sampai pada tahap pengembangan saja. Metode pengumpulan data yang dilakukan adalah pengumpulan data primer dengan instrumen penelitian adalah angket kuesioner. Subjek penelitian yaitu ahli berjumlah 4 orang. Teknik analisis data yang digunakan adalah analisis statistik kualitatif kuantitatif. Hasil penelitian menunjukkan bahwa media pembelajaran gambar berseri ini valid dan layak untuk diterapkan. Berdasarkan uji validitas materi dan media, dengan rata-rata nilai CVR 1,00 dan nilai CVI 1,00. Dapat disimpulkan bahwa pengembangan media gambar berseri untuk meningkatkan kemampuan berbahasa lisan anak usia dini memiliki 3 tahapan dan dinilai valid serta layak untuk diterapkan. Implikasi penelitian ini yaitu media yang dikembangkan dapat digunakan oleh guru dalam proses pembelajaran sehingga dapat meningkatkan kemampuan berbahasa lisan pada siswa usia dini.
Systems of innovation perspectives and challenges

The national system of innovation approach has attracted both academics and policy makers. There has been different emphasis laid by those who both originated the concept and developed it further for policy learning applications. From the firm level to the global innovation networks, the varieties and differences in system of innovation functions, activities and factors continue to attract debate amongst the leading scholars. The main challenge is to translate the system of innovation from a conceptual framework to theory that feeds a concrete practice. By assessing closely the existing work on systems of innovation and by going beyond the current literature, I have formulated the functions, constituents, activities, factors and boundaries that the system of innovation provides for better policy formulation and application in practice.
THE EFFECTS OF HYDROPHILIC AND HYDROPHOBIC REAR-WINDOW TREATMENTS ON VISUAL PERFORMANCE

This study consisted of a survey and a field experiment to evaluate the potential benefits of hydrophilic treatments for motor vehicle glazing. The survey examined the subjective assessments of 15 drivers whose vehicles had a portion of the rear window and one of the side windows treated with a hydrophilic coating. The field experiment evaluated the effects of hydrophilic and hydrophobic treatments, relative to an untreated condition, on driver visual acuity under simulated wind and rain conditions, both during the day and during the night. Additional independent variables included whether headwind was present, rain rate, and age. The results of the survey show that drivers did not report a benefit of hydrophilic treated areas compared to untreated areas of the side or rear windows. Consistent with the survey results, the field experiment showed that hydrophilic treatment did not improve visual performance. However, significant improvements in visual performance were associated with hydrophobic treatment of the rear window. The findings from the field experiment support previous research that showed significant improvements in visual acuity associated with hydrophobic treatment of the windshield. On the other hand, the present study found no subjective or objective benefits of applying hydrophilic treatments to rear or side windows.
A comparison of artificial intelligence techniques for predicting hyperforin content in Hypericum perforatum L. in different ecological habitats

Abstract Hyperforin, a major bioactive constituent of Hypericum concentration, is impacted by various phenological phases and soil characteristics. We aimed to design a model predicting hyperforin content in Hypericum perforatum based on different ecological and phenological conditions. We employed artificial intelligence modeling techniques including multilayer perceptron (MLP), radial basis function (RBF), and support vector machine (SVM) to examine the factors critical in predicting hyperforin content. We found that the MLP model (R 2 = .9) is the most suitable and precise model compared with RBF (R 2 = .81) and SVM (R 2 = .74) in predicting hyperforin in H. perforatum based on ecological conditions, plant growth, and soil features. Moreover, phenological stages, organic carbon, altitude, and total N are detected in sensitivity analysis as the main factors that have a considerable impact on hyperforin content. We also report that the developed graphical user interface would be adaptable for key stakeholders including producers, manufacturers, analytical laboratory managers, and pharmacognosists.
Analysis of Challenges Facing Rice Processing in Nigeria

Rice is the most economically important food crop in many developing countries and has also become a major crop in many developed countries where its consumption has increased considerably. It has become necessary to meet the demand of the world’s current population growth rate, and the least costly means for achieving this aim is to increase rice productivity, wherever possible. The main challenges encountered by rice processors in Nigeria are to find appropriate solutions for quality rice processing. Therefore this work provides basic information about the challenges of rice processing and focuses on the challenges faced by the small scale rice processors and reasons for continuous rice importation with a view to guiding decision-making to be self-sufficient in rice production, thereby making some improvement in Nigerian economy.
Glutathione S-Transferase Omega-2 and Transforming Growth Factor-β1 Polymorphisms in Iranian Glaucoma Patients

Background To investigate the association of glutathione s-transferase omega 2 (GSTO2) (142N > D) and transforming growth factor-β1 (TGF-β1) (869T > C) gene polymorphisms on the pathogenesis of two common types of glaucoma (including primary open-angle glaucoma (POAG) and chronic angle-closure glaucoma (CACG)) in the Iranian population. Methods A total of 100 glaucoma patients (60% males and 40% females with an age mean ± SD of 34.66 ± 14.25 years; 56 cases of POAG and 44 cases of CACG) were enrolled in this study. GSTO2 (142N > D) and TGF-β1 (869T > C) polymorphisms were evaluated by PCR-based methods in patients and controls. Results At locus GSTO2 (142N > D), the odds of ND genotype with respect to DD and NN genotypes were 1.55 and 2.08 times higher in POAG and CACG patients compared to those of patients in the control group (95% CI1: 0.80–2.98; 95% CI2: 1.00–4.33) which was statistically significant in CACG patients. However, the odds of DD and NN genotypes against the reference genotype in two patients group were not statistically significant as compared to those of patients in the control group. There was a significant association between the ND genotype and male patients (OR = 2.28, 95% CI: 1.06–4.92). The analysis of TGF-β1 (869T > C) polymorphisms showed no significant difference between the genotypes of TGF-β1 (869T > C) polymorphisms in patients and control groups; however, the CT genotype of TGF-β1 significantly differed between female controls and patients (OR = 0.42, 95% CI: 0.18–0.96). Conclusion The presented results revealed that there was a significant association between the ND genotype of GSTO2 and the pathogenesis of glaucoma. Furthermore, this genotype can be considered as a sex-dependent genetic risk factor for the development of glaucoma. In contrast, the CT genotype of TGF-β1 is suggested to be a protective genetic factor against the pathogenesis of glaucoma.