Miracle-dz/UniFAR-FTUs huggingface dataset:
Health economic evaluation of an mRNA high-risk human papillomavirus (HR-HPV) assay versus a DNA HR-HPV assay for the proposed French cervical screening programme

Objective: Population screening programmes must make good use of resources for the health system and users. To evaluate impacts of the type of diagnostic test in the new French cervical screening programme, an messenger ribonucleic acid (mRNA) high-risk human papillomavirus assay was compared to a deoxyribonucleic acid (DNA) high-risk human papillomavirus assay for a hypothetical cohort of women aged 25 to 65 years. Perspective: This evaluation takes the perspective of the French healthcare system. Setting: France Methods: A decision tree model reflecting the French cervical screening algorithms was parametrised using French cost and population data and the Danish Horizon study. The outcomes were total costs, and number of colposcopies, HPV tests and cytology tests for the cohort. One-way and probabilistic sensitivity analyses and scenarios analyses were conducted to test the robustness of results to parameter and structural uncertainty. Results: Adopting an mRNA versus DNA assay as part of national cervical screening in France is estimated to save €6.5 million (95% credibility intervals €-1.3 - €13.5 million) and prevent 47,795 (95% credibility intervals 35,309 - 60,139) unnecessary colposcopies, 38,666 unnecessary HPV tests and 121,670 cytology tests over two years for a cohort of 2,168,806 million women aged 25 to 65 years. Sensitivity analyses indicated robust results across a range of inputs. Conclusion: The choice of high-risk human papillomavirus assay makes a significant difference to resource use and costs and is important to consider when implementing cervical screening in France. Using an mRNA versus DNA assay can result in cost savings and reductions in unnecessary testing and procedures, which in turn benefits women and the health care system.
Perfil socioeconômico, epidemiológico e farmacoterapêutico de idosos institucionalizados de Brasília, Brasil

O objetivo deste estudo e descrever o perfil socioeconomico, epidemiologico e farmacoterapeutico de 154 idosos de cinco Instituicoes de Longa Permanencia de Brasilia por meio de questionario adaptado do Metodo Dader e complementado com informacoes dos prontuarios. A amostra e caracterizada por individuos solteiros e viuvos, em sua maioria homens, com idade media de 74,6 anos, sedentarios, com estado cognitivo preservado, baixa renda mensal e baixo nivel de escolaridade. O grupo consome de quatro a cinco medicamentos e e acometido, principalmente, por disturbios psiquiatricos e cardiovasculares. Os medicamentos mais utilizados sao os cardiovasculares e os psicofarmacos. A adesao a farmacoterapia e comprometida pela falta de conhecimento sobre a prescricao medica atual, dificuldade de acesso e recusa em tomar os medicamentos prescritos. Resultados sugerem que tal perfil influencia a qualidade e a eficacia da terapeutica medicamentosa indicando a necessidade de implementacao de um acompanhamento farmacoterapeutico a esses idosos bem como de politicas publicas de saude mais focadas nas particularidades dessa populacao a fim de proporcionar melhoria da qualidade de vida e reducao dos custos com assistencia a saude.
Instance invariant visual servoing framework for part‐aware autonomous vehicle inspection using MAVs

Visual servoing approaches navigate a robot to the desired pose with respect to a given object using image measurements. As a result, these approaches have several applications in manipulation, navigation and inspection. However, existing visual servoing approaches are instance specific, that is, they control camera motion between two views of the same object. In this paper, we present a framework for visual servoing to a novel object instance. We further employ our framework for the autonomous inspection of vehicles using Micro Aerial Vehicles (MAVs), which is vital for day‐to‐day maintenance, damage assessment, and merchandising a vehicle. This visual inspection task comprises the MAV visiting the essential parts of the vehicle, for example, wheels, lights, and so forth, to get a closer look at the damages incurred. Existing methods for autonomous inspection could not be extended for vehicles due to the following reasons: First, several existing methods require a 3D model of the structure, which is not available for every vehicle. Second, existing methods require expensive depth sensor for localization and path planning. Third, current approaches do not account for the semantic understanding of the vehicle, which is essential for identifying parts. Our instance invariant visual servoing framework is capable of autonomously navigating to every essential part of a vehicle for inspection and can be initialized from any random pose. To the best our knowledge, this is the first approach demonstrating fully autonomous visual inspection of vehicles using MAVs. We have validated the efficacy of our approach through a series of experiments in simulation and outdoor scenarios.
Alterations of Blood Immune Cells in Elderly Patients with COVID-19 and with or without Pre-Existing Type 2 Diabetes

Elderly individuals, especially those with pre-existing conditions like type 2 diabetes mellitus (T2DM), have a high risk for developing severe cases of COVID-19. The aim of this work was to characterize the alterations of blood immune cells (BIC) in patients with symptomatic COVID-19 and confirmed SARS-CoV-2 infection, ≥60 years and who needed hospitalization in the Centro de Salud Hospital of Tucuman, Argentina, during the second peak of the pandemic for COVID-19 care (O 2 , corticosteroids and antibiotics). The hospital treatment normalized the levels of BIC (day 5) in 30% of patients who were those with no comorbidities. In patients with T2DM, BIC recovery was variable. In T2DM patients who required administration of plasma (30%), prolonged O 2 therapy (40%) or referral to the intensive care unit (10%) significant reductions of CD16 + CD56 + , CD3 + HLA − DR + CD25 + , CD4 + and CD8 + cells were observed between days 0 and 5. In line with previous studies, our results show that absolute counts of major lymphocyte subsets in blood are significantly and substantially decreased during the course of severe COVID-19 disease in elderly patients. These BIC alterations may persist despite clinical care in elderly patients with T2DM. Further studies are needed to investigate the utility of early lymphocyte subset measurements as prognostic biomarkers of disease severity, mortality, and response to treatment in COVID-19 elderly patients with T2DM.
Teaching Race, Colonialism, and Theology in a Joint Project in North America and Africa: Insights from the Project

Abstract How do race and lived experiences of this construct impact student theological understandings? We embarked on a joint pedagogical venture spanning two continents about race and theology with groups of students whose encounters with race and its impacts on theology were markedly different—including students whose lives and education have been formed by colonialism and its continuing legacies, and students whose grasp of theological systems had hardly addressed the effects of racism on theology. In this article, we share what we learned and offer recommendations for others looking to use this as a model.
Trends and Geographic Variabilities in Benzodiazepines Prescription in Primary Care to Older Adults: A 3-Year Population-Based Ecological Study in Portugal

(1) Background: According to the World Health Organization (WHO), benzodiazepines (BZD) are considered essential medicines for the treatment of several mental disorders in older adults over 65 years old. However, the long-term use of BZD could present a harmful impact on this population, leading to cognitive deficits, drug dependence, falls, and fractures. This study aims to analyze trends of BZD prescription to Portuguese older adults in the primary care setting, and to analyze the change in the prescription rate of BZD over time, assessing the geographical variability in mainland Portugal. (2) Methods: A nationwide, retrospective ecological study was performed between January 2019 and December 2021 for BZD prescribing data reported in a national public database for all persons aged 65 and older in mainland Portugal (about 2.4 million). Trends of BZD by defined daily doses (DDD) and per 1000 older adults’ inhabitants per day (DID) were analyzed. (3) Results: A total of 19 BZD were included in this study and more than 1 million BZD prescriptions were recorded in each year of this study period. BZD prescriptions were three times higher in females than in males. Alprazolam, lorazepam, diazepam, ethyl loflazepate, and bromazepam were the most prescribed BZD over the years, presenting the higher DDD and DID values. (4) Conclusions: Despite the DID value growth of several BZD, Portugal is now showing stable BZD prescriptions in older adults, between the years 2019 to 2021. More studies are needed to access if these results are a consequence of successful health programs or just a consequence of the pandemic context that we are facing, which limited older adults’ clinical appointments.
Associations among Cotyledon Developmental Stability, Canalization, and Phenotypic Plasticity in Response to Shading and Burial Depth in Five Herbaceous Species at Early Seedling Stage

Premise of research. Cotyledons have important functions in the early seedling stage and have important effects on later stages, but we know little about the relationships among developmental stability, canalization, and phenotypic plasticity in cotyledons. Methodology. We conducted a field experiment with five herbaceous species, subjecting them to contrasting light conditions and burial depths and measuring their cotyledon size and fluctuating asymmetry (random deviation from perfect bilateral symmetry, indicating developmental stability or instability), coefficient of variation, and plasticity of cotyledon size, to investigate the relationships among cotyledon developmental stability, canalization, and plasticity in response to shading and deep burial. Pivotal results. Pharbitis purpurea, Convolvulus arvensis, and Carpesium abrotanoides had increased cotyledon size in response to shading at both burial depths, and Abutilon theophrasti showed reduced cotyledon size in response to shading versus full light at shallow depth but greater cotyledon size in response to both shading and deep burial. Shading increased cotyledon fluctuating asymmetry of P. purpurea and C. abrotanoides, while deep burial decreased it. Cotyledon fluctuating asymmetry had positive correlations with coefficient of variation and plasticity in response to shading, with little correlation between coefficient of variation and plasticity. Conclusions. Results suggested that A. theophrasti may have greater tolerance for multiple stresses than the other species, and deep burial may improve shade tolerance of cotyledons through moderate levels of stress selection. Both developmental instability and decreased canalization may indicate the state of faster growth. Developmental instability can facilitate more active response to shading in cotyledons, while the relationship between canalization and plasticity should be more complex.
A tool for developing guidelines for institutional policy: a 60 indicator inventory for assessing the age-friendliness of a university

ABSTRACT This study seeks to develop Age-Friendly University (AFU) implementation guidelines to enable universities to self-identify their age-friendliness levels and establish specific strategies toward becoming an AFU. The survey was completed by primary leads for 26 AFUs-recognized institutions globally. The questionnaires included an inventory of 68 possible attributes of an AFU. The respondents were asked to (a) report the status of their institution in terms of performance on the attributes and (b) state the relative desirability of each attribute as a potential guideline for assessing the performance of AFU attributes. For institution’s performance, ‘Social engagement and support’ had the highest (3.32) age-friendliness level, followed by an ‘Age-friendly environment’ (3.31), ‘Administrative support’ (3.15), Lifelong learning’ (3.11), and ‘Reflecting the needs of older people’ (2.83). Furthermore, the overall score was highest in Canada (3.82), followed by Europe (3.51), the USA (3.14), and Asia (2.67). Among attributes, ‘There are elevators in major buildings (that older adults use frequently)’ was the highest (4.40); followed by ‘The campus and surrounding environment in our school are clean for older adults to use’ (4.28). We also asked participants about “the adequacy of the AFU as a guideline. ‘Members of our university’s community are respectful and friendly toward older adults’ was the highest (4.43). ” However, in this study, 8 attributes scored less than 3 points for appropriateness. Consequently, we condensed the instrument to 60 attributes. This study is novel in proposing guidelines to implement strategies to apply and operationalize the somewhat abstract concept of age-friendliness of universities.
Ergonomic Risk Assessment in Construction Manufacturing Facilities

ii PREFACE . iv ACKNOWLEDGEMENTS . vi TABLE OF CONTENTS . vii LIST OF FIGURES . xi LIST OF TABLES . xiii LIST OF ABBREVIATIONS . xv Chapter 1: INTRODUCTION . 1 1.1 Background and Motivation . 1 1.1.1 Physical demand analysis and modified work . 3 1.1.2 Risk assessment tools . 4 1.1.3 Physical data collection methods . 5 1.2 Research Objectives . 6 1.3 Thesis Organization . 8 Chapter 2: PHYSICAL DEMAND ANALYSIS . 10 2.
A re-examination of the growth of the gummy shark (Mustelus antarcticus) from Queensland, Australia

The gummy shark ( Mustelus antarcticus ) is endemic to Australia and is the target of commercial ﬁ sheries in southern Australia. However, the Queensland population is subjected to low levels of ﬁ shing mortality. The present study re-analysed a limited length-at-age dataset collected from central Queensland to estimate growth parameters in a Bayesian framework, with informative priors for size-at-birth and maximum size. Growth parameters were estimated using a multimodel approach. This study showed that M. antarcticus caught in Queensland exhibits slow growth compared with conspeci ﬁ cs in southern Australia, and females grow slower and larger than do males. The combined length-at-age data for males and females was best described by the von Bertalanffy growth function and the growth parameters were L ∞ = 1852 mm (total length, TL), L 0 = 261 mm TL and k = 0.044 year − 1 for males and females combined. The ‘ BayesGrowth ’ R package offers a simple method to minimise bias in the estimation of growth parameters from a limited length-at-age dataset in a Bayesian framework.
Central planning casts long shadows: new evidence on misallocation and growth

ABSTRACT We analyze the link between resource misallocation resulting from central planning and subsequent long-term economic growth under a market-based system. We construct two novel data sets for Poland. We show that misalignment of resources under central planning coincides with lower subsequent economic growth, despite the fact that market mechanisms are reinstated. This result is robust even three decades after the collapse of central planning. We provide several explanations for these patterns.
Mapping Nanoparticles in Hydrogels: A Comparison of Preparation Methods for Electron Microscopy

The distribution of noble metal nanoparticles (NMNPs) in hydrogels influences their nanoplasmonic response and signals used for biosensor purposes. By controlling the particle distribution in NMNP-nanocomposite hydrogels, it is possible to obtain new nanoplasmonic features with new sensing modalities. Particle positions can be characterized by using volume-imaging methods such as the focused ion beam-scanning electron microscope (FIB-SEM) or the serial block-face scanning electron microscope (SBFSEM) techniques. The pore structures in hydrogels are contained by the water absorbed in the polymer network and may pose challenges for volume-imaging methods based on electron microscope techniques since the sample must be in a vacuum chamber. The structure of the hydrogels can be conserved by choosing appropriate preparation methods, which also depends on the composition of the hydrogel used. In this paper, we have prepared low-weight-percentage hydrogels, with and without gold nanorods (GNRs), for conventional scanning electron microscope (SEM) imaging by using critical point drying (CPD) and hexamethyldisilazane (HMDS) drying. The pore structures and the GNR positions in the hydrogel were characterized. The evaluation of the sample preparation techniques elucidate new aspects concerning the drying of hydrogels for SEM imaging. The results of identifying GNRs positioned in a hydrogel polymer network contribute to the development of mapping metal particle positions with volume imaging methods such as FIB-SEM or SBFSEM for studying nanoplasmonic properties of NMNP-nanocomposite hydrogels.
Emotional Valence and Body Representation: An Experiment on Embodied Cognition

Background: In line with Lakoff’s theory of embodied cognition, several studies in the field of emotional processing have demonstrated that positive and negative valence is represented based on spatial and bodily characteristics. Objectives: The present study aimed to investigate the implicit link between body parts and the emotional valence of Persian words. Materials and Methods: The participants included 33 right-handed undergraduate students in the field of psychology who were selected via the convenience sampling method. A priming task with emotional negative and positive words (prime) was used, and the participants had to recognize the leftness or rightness of hand stimuli (target). Reaction times were recorded for target stimuli. The data were analyzed in SPSS software (version 24) using repeated-measures ANOVA. Results: The obtained results pointed to the implicit association of positive and negative words with bodily features (right hand and left hand). Conclusion: The findings of the current study are finally discussed within theories of embodied cognition, as well as hemispheric and language processing, for emotional stimuli.
A Hybrid Framework Combining Data-Driven and Catenary-Based Methods for Wide-Area Powerline Sag Estimation

This paper is concerned with the airborne-laser-data-based sag estimation for wide-area transmission lines. A systematic data processing framework is established for multi-source data collected from power lines, which is applicable to various operating conditions. Subsequently, a k-means-based clustering approach is employed to handle the spatial heterogeneity and sparsity of powerline corridor data after comprehensive performance comparisons. Furthermore, a hybrid model of the catenary and XGBoost (HMCX) method is proposed for sag estimation, which improves the accuracy of sag estimation by integrating the adaptability of catenary and the sparsity awareness of XGBoost. Finally, the effectiveness of HMCX is verified by using power data from 116 actual lines.
Construction and Validation of a Recurrent Risk Nomogram Model for Non-Small Cell Lung Cancer within 1 Year after Radical Resection

Objective To explore the risk factors of recurrence within 1 year after radical resection of non-small cell lung cancer (NSCLC) and construct the nomogram model. Methods The clinical data of 186 patients with NSCLC treated with radical surgery in Affiliated Hospital of Youjiang Medical University for Nationalities of Baise were retrospectively analyzed. Multivariate logistic regression was applied to analyze the risk factors of recurrence within 1 year after radical resection of NSCLC. The R language (R 4.0.3 software package) was used in constructing the nomogram model, and the predictive value of the model was evaluated. Results The recurrence rate of 186 patients within 1 year after radical surgery was 29.57%. After multivariate logistic regression analysis, pathological stage, number of lymph node metastasis, chronic obstructive pulmonary disease (COPD), postoperative plasma D-dimer, and carcinoembryonic antigen were independent factors for recurrence within 1 year after radical resection of NSCLC (P < 0.05). Based on the above independent risk factors, a nomogram model was established, with the distinction of AUC = 0.891 (95% CI: 0.819–0.964) and sensitivity and specificity of 70.3% and 97.8%, respectively. The calibration curve was close to the ideal curve. External validation of the model showed AUC = 0.801 (95% CI: 0.674–0.928), and sensitivity and specificity were 66.7% and 84.2%, respectively. Conclusion The recurrence of NSCLC within 1 year after radical surgery was related to a variety of factors, and the nomogram model constructed based on risk factors had good goodness of fit, calibration, consistency of prediction, and prediction efficiency.
Prevalence of Dental Caries in Children in Mymensingh and Its Associated Risk Factors: A Cross-Sectional Study

Background: Children suffer from various oral and periodontal diseases. Dental caries is one of the most prevalent oral diseases among children in the world. This study was conducted to identify the prevalence and risk factors of dental caries in children in Mymensingh, Bangladesh. Methods: A cross-sectional study was conducted on 362 pediatric patients who attended the Dental Unit of Mymensingh Medical College from March to September 2019. The sample size was calculated using a statistical formula and the children were selected using a systematic random sampling technique. Children and their guardians were interviewed and data were recorded using a structured questionnaire. Risk factors were analyzed using multivariate logistic regression. Results: The overall prevalence of dental caries was 82.7%. The prevalence of caries was significantly higher in aged children (8–10 years) and also in rural, low-income, and illiterate families. Seven significant risk factors were identified that included residence in the rural area (OR: 7.31 [1.73–30.83]), a parental income of BDT ≤ 20,000 per month (OR: 4.75 [1.49–15.05]), reduced duration (≤1 min) of teeth cleaning (OR: 18.54 [2.05–168.17]), teeth cleaning before breakfast (OR: 93.30 [10.95–795.32]), the spoon-feeding method (OR: 12.57 [2.09–75.61]), long-term (37–48 months) breastfeeding (OR: 212.53 [8.69–5195.25]), and family oral problem (OR: 8.20 [2.57–26.16]). Conclusions: The prevalence of dental caries among the children in Mymensingh is very high and was associated with residence in rural areas, parental income, reduced duration of teeth cleaning, teeth cleaning before breakfast, the spoon-feeding method, long-term breastfeeding, and family oral problems.