Miracle-dz/UniFAR-FTUs huggingface dataset:
Fear of missing out and problematic smartphone use among Chinese college students: The roles of positive and negative metacognitions about smartphone use and optimism

Background Problematic smartphone use (PSU) has become a common phenomenon among college students. Fear of missing out (FoMO) is an important factor affecting PSU, but how FoMO affects PSU is not clear. Therefore, the mediating effect of positive and negative metacognitions about smartphone use (PMSU and NMSU) and the moderating effect of optimism are explored. Methods 514 Chinese college students aged 17 to 25 from 6 Chinese universities were investigated with the Trait-State FoMO Scale, the Metacognitions about Smartphone Use Questionnaire, the Temperament Optimism Scale, and the Smartphone Addiction Scale for College Students. The data were analyzed with SPSS software. Results FoMO was positively associated with PSU, PMSU and NMSU mediated this association. Optimism moderated the relationship between FoMO and PSU, i.e., FoMO had a less prominent positive effect on PSU for college students with a high level of optimism. Conclusions There is a positive relationship which exists between FoMO and PSU among college students. In addition, PMSU and NMSU play mediating roles in FoMO and PSU, and optimism plays an moderating role in FoMO and PSU. These findings can help not only educators understand the predictors of PSU and develop interventions to effectively prevent PSU among college students but also college students reduce the level of PSU by improving their understanding of PMSU and NMSU and optimism level.
Utilization of physician mental health services by birthing parents with young children during the COVID-19 pandemic: a population-based, repeated cross-sectional study

Background: The COVID-19 pandemic and nonpharmaceutical interventions that reduced the spread of infection had impacts on social interaction, schooling and employment. Concerns have been raised about the impact of these disruptions on the mental health of high-risk groups, including birthing parents of young children. Methods: This population-based, repeated cross-sectional study used health administrative databases in Ontario, Canada, to link children to birth parents and to measure subsequent mental health visits of birthing parents of younger (age 0–5 yr) and school-aged (6–12 yr) children. We used a repeated cross-sectional study design to estimate expected rates for visits to physicians for mental health diagnoses, based on prepandemic trends (March 2016–February 2020), and to compare those to observed visit rates during the March 2020–November 2021 period of the pandemic. Results: We identified 2 cohorts: 986 870 birthing parents of younger children and 1 012 997 birthing parents of school-aged children. In both cohorts, observed visit rates were higher than expected in the June 2020–August 2020 quarter (incidence rate ratio [IRR] 1.13, 95% confidence interval [CI] 1.10–1.16; and IRR 1.10, 95% CI 1.07–1.13, respectively), peaked in December 2020–February 2021 (IRR 1.24, 95% CI 1.20–1.27; and IRR 1.20, 95% CI 1.16–1.23) and remained higher than expected in September 2021–November 2021 (IRR 1.12, 95% CI 1.08–1.16; and IRR 1.09, 95% CI 1.06–1.13). The increases were driven mostly by visits for mood and anxiety disorders, and trends in increases were similar across physician type, birthing-parent age and deprivation quintile. Interpretation: The COVID-19 pandemic was associated with increased mental health visits for parents of young children. This raises concerns about mental health impacts and highlights the need to address these concerns.
A new source of the midlatitude ionospheric peak density structure revealed by a new Ionosphere‐Plasmasphere model

The newly developed Ionosphere‐Plasmasphere (IP) model has revealed neutral winds as a primary source of the “third‐peak” density structure in the daytime global ionosphere that has been observed by the low‐latitude ionospheric sensor network GPS total electron content measurements over South America. This third peak is located near −30° magnetic latitude and is clearly separate from the conventional twin equatorial ionization anomaly peaks. The IP model reproduces the global electron density structure as observed by the FORMOSAT‐3/COSMIC mission. The model reveals that the third peak is mainly created by the prevailing neutral meridional wind, which flows from the summer hemisphere to the winter hemisphere lifting the plasma along magnetic field lines to higher altitudes where recombination is slower. The same prevailing wind that increases the midlatitude density decreases the low‐latitude density in the summer hemisphere by counteracting the equatorial fountain flow. The longitudinal variation of the three‐peak structure is explained by the displacement between the geographic and geomagnetic equators.
Occupational noise exposure, noise annoyance, hearing-related symptoms, and emotional exhaustion - a participatory-based intervention study in preschool and obstetrics care

Abstract A participatory-based intervention was performed in Sweden, aimed at improving the sound environment in one preschool (n = 20) and one obstetric ward (n = 50), with two controls each (n = 28, n = 66). Measured sound levels, and surveys of noise annoyance, hearing-related symptoms and emotional exhaustion were collected before, and three and nine months after the interventions, comparing intervention and control groups over time. The results of this first implementation in a limited number of workplaces showed significantly worsening of hyperacusis, sound-induced auditory fatigue, emotional exhaustion and increased sound levels in the preschool, and worsening of noise annoyance in both intervention groups. Increased risk awareness, limited implementation support and lack of psychosocial interventions may explain the worsening in outcomes, as might the worse baseline in the intervention groups. The complexity of the demands in human-service workplaces calls for further intervention studies.
Nasal Patency Measurement: State of the Art of Acoustic Rhinometry

Abstract Nasal obstruction is one of the main symptoms of different nasal pathologies. Many physiological and pathological conditions can produce nasal airflow impairment causing nasal obstruction and affecting patients' quality of life. There are different methods for the measurement of nasal obstruction, but in clinical practice the most common used are acoustic rhinometry, rhinomanometry, and peak nasal inspiratory flow. This review describes the fundamentals of acoustic rhinometry, its normal values, the different physiological and pathological conditions that can modify nasal patency, and the utility of this instrument for the measurement of nasal obstruction in clinical practice. Acoustic rhinometry is a simple test, so it is suitable for measurements in the pediatric population, i.e., for evaluating adenoid hypertrophy. Acoustic rhinometry normal values are available, unilaterally and bilaterally for pediatric and adult populations. Acoustic rhinometry has been demonstrated to be reproducible and even superior to rhinomanometry when measuring nasal modifications during challenges. It is possible to use acoustic rhinometry before and after nasal surgery. Measuring nasal cavities volume and cross-sectional area, acoustic rhinometry is particularly indicated in rhinosurgery, especially for the evaluation of spreader grafts. Brief considerations about the correlation between nasal symptoms, in particular the subjective sensation of nasal obstruction, and the acoustic rhinometry results as well as the correlation of acoustic rhinometry with other methods for the measurement of nasal obstruction are also reported. Objective and subjective evaluation of nasal obstruction gives different information that together optimizes the diagnosis and the treatment of rhinologic patients. Acoustic rhinometry alone or in combination of other instruments for the measurement of nasal obstruction or patency should be used regularly in every outpatient clinic that treats patients with nasal obstruction as there is an increasing need of evidence-based therapies.
A multi‐proxy sediment record of late Holocene and recent climate change from a lake near Ny‐Ålesund, Svalbard

Jiang, S. , Liu, X. , Sun, J., Yuan, L. , Sun, L. & Wang, Y. 2011: A multi‐proxy sediment record of late Holocene and recent climate change from a lake near Ny‐Ålesund, Svalbard. Boreas, Vol. 40, pp. 468–480. 10.1111/j.1502‐3885.2010. 00198.x. ISSN 0300‐9483
Early Palaeozoic metasomatism of the Archaean Napier Complex, East Antarctica

Abstract Emplacement of post-tectonic Early Palaeozoic pegmatites on Tonagh Island, Napier Complex, East Antarctica, was accompanied by the introduction of aqueous low-salinity fluids at mid-P upper-amphibolite facies conditions (c. 8 kbar, c. 680 °C). Fluid–wall-rock interaction resulted in the development of spectacular alteration selvedges, in the immediate vicinity of the pegmatites, in adjacent Archaean orthogneisses. Archaean wall-rocks affected by the infiltration of aqueous fluids show contrasting patterns of K, Na and Ca metasomatism, which we demonstrate was fundamentally controlled by disequilibrium of invading fluids with wall-rock feldspars, rather than fluid flow up or down regional pressure or temperature gradients. Other species, such as the rare earth elements (REE; except Eu), Y, P, Rb, Th, U and Pb, for example, show significant enrichment in the metasomatized wall-rock in both examples studied. Enrichment of P (and Y), sympathetic with that of REE enrichment, is consistent with recent suggestions that REE transport in fluids may be enhanced by complexing with dissolved P and Y compounds. Dehydration and partial melting of previously unmetamorphosed sedimentary rocks, underthrust beneath the SW Napier Complex, has been long considered a viable source for felsic pegmatites (and associated fluids) observed in that region. Our results are consistent with the hypothesis that underplated sedimentary rocks were a viable source for pegmatite melt and aqueous fluids. Furthermore, as our study demonstrates a plausible relationship between Early Palaeozoic (c. 500–530 Ma) pegmatites and fluid infiltration, we suggest that dehydration and prograde partial melting of the underthrust sedimentary rocks beneath the Napier Complex occurred, at least in part, by convergent Early Palaeozoic tectonism.
Meta-Analysis of Pulse Transition Features in Non-Invasive Blood Pressure Estimation Systems: Bridging Physiology and Engineering Perspectives

The pulse transition features (PTFs), including pulse arrival time (PAT) and pulse transition time (PTT), hold significant importance in estimating non-invasive blood pressure (NIBP). However, the literature showcases considerable variations in terms of PTFs' correlation with blood pressure (BP), accuracy in NIBP estimation, and the comprehension of the relationship between PTFs and BP. This inconsistency is exemplified by the wide-ranging correlations reported across studies investigating the same feature. Furthermore, investigations comparing PAT and PTT have yielded conflicting outcomes. Additionally, PTFs have been derived from various bio-signals, capturing distinct characteristic points like the pulse's foot and peak. To address these inconsistencies, this study meticulously reviews a selection of such research endeavors while aligning them with the biological intricacies of blood pressure and the human cardiovascular system (CVS). Each study underwent evaluation, considering the specific signal acquisition locale and the corresponding recording procedure. Moreover, a comprehensive meta-analysis was conducted, yielding multiple conclusions that could significantly enhance the design and accuracy of NIBP systems. Grounded in these dual aspects, the study systematically examines PTFs in correlation with the specific study conditions and the underlying factors influencing the CVS. This approach serves as a valuable resource for researchers aiming to optimize the design of BP recording experiments, bio-signal acquisition systems, and the fine-tuning of feature engineering methodologies, ultimately advancing PTF-based NIBP estimation.
Effects of egg as an early complementary food on growth of 6- to 9-month-old infants: a randomised controlled trial

Abstract Objective: To assess the effect of daily egg consumption for six months on linear growth (primary outcome), weight-for-age, weight-for-length, mid-upper arm circumference-for-age, head circumference-for-age Z-scores, gross motor milestones development, anaemia and iron status (secondary outcomes) in a low socioeconomic community. Participants: Infants aged 6 to 9 months living in the peri-urban Jouberton area, in the Matlosana Municipality, South Africa. Design: A randomised controlled trial with a parallel design was implemented. Eligible infants were randomly allocated to the intervention (n 250) receiving one egg/day and the control group (n 250) receiving no intervention. The participants were visited weekly to monitor morbidity and gross motor development, with information on adherence collected for the intervention group. Trained assessors took anthropometric measurements, and a blood sample was collected to assess anaemia and iron status. There was blinding of the anthropometric assessors to the groups during measurements and the statistician during the analysis. Results: Baseline prevalence of stunting, underweight, wasting, overweight and anaemia was 23·8 %, 9·8 %, 1·2 %, 13·8 % and 29·2 %, respectively, and did not differ between groups. Overall, 230 and 216 participants in the intervention and control groups completed the study, respectively. There was no intervention effect on length-for-age, weight-for-age, weight-for-length Z-scores, gross motor milestone development, anaemia and iron status. Conclusions: Daily egg intake did not affect linear growth, underweight, wasting, motor milestones development, anaemia and iron status. Other interventions are necessary to understand the effect of animal-source food intake on children’s growth and development. This trial was registered at https://clinicaltrials.gov/ (NCT05168085).
Impact of surface receptors TLR2, CR3, and FcγRIII on Rhodococcus equi phagocytosis and intracellular survival in macrophages

ABSTRACT The virulence-associated protein A (VapA) produced by virulent Rhodococcus equi allows it to replicate in macrophages and cause pneumonia in foals. It is unknown how VapA interacts with mammalian cell receptors, but intracellular replication of avirulent R. equi lacking vapA can be restored by supplementation with recombinant VapA (rVapA). Our objectives were to determine whether the absence of the surface receptors Toll-like receptor 2 (TLR2), complement receptor 3 (CR3), or Fc gamma receptor III (FcγRIII) impacts R. equi phagocytosis and intracellular replication in macrophages, and whether rVapA restoration of virulence in R. equi is dependent upon these receptors. Wild-type (WT) murine macrophages with TLR2, CR3, or FcγRIII blocked or knocked out (KO) were infected with virulent or avirulent R. equi, with or without rVapA supplementation. Quantitative bacterial culture and immunofluorescence imaging were performed. Phagocytosis of R. equi was not affected by blockade or KO of TLR2 or CR3. Intracellular replication of virulent R. equi was not affected by TLR2, CR3, or FcγRIII blockade or KO; however, avirulent R. equi replicated in TLR2-/- and CR3-/- macrophages but not in WT and FcγRIII-/-. rVapA supplementation did not affect avirulent R. equi phagocytosis but promoted intracellular replication in WT and all KO cells. By demonstrating that TLR2 and CR3 limit replication of avirulent but not virulent R. equi and that VapA-mediated virulence is independent of TLR2, CR3, or FcγRIII, our study provides novel insights into the role of these specific surface receptors in determining the entry and intracellular fate of R. equi.
Early Ecological Responses to Hydrologic Restoration of a Tidal Pond and Salt Marsh Complex in Narragansett Bay, Rhode Island

Abstract Tidal exchange was restored to the flow-restricted, 2.3-ha Potter Pond salt marsh on Prudence Island in the Narragansett Bay National Estuarine Research Reserve in April 2003. Ecological monitoring was conducted for 1 year before and 2 years after restoration to quantify ecological changes. Simultaneous monitoring was conducted in a nearby marsh that served as an experimental control. Tidal restoration increased the tide range in Potter Pond from approximately 4 cm in 2000 to 120 cm in 2003. After 2 years of restoration, the height of Spartina alterniflora remained unchanged, and the same was true of the composition of the emergent marsh vegetation community. However, by 2004, the percent cover of live Phragmites australis decreased by 69%, and the average height of Phragmites decreased by 76 cm. Seven additional bird species were observed at Potter Pond after 1 year of restoration, and the number of birds observed increased from 6 to 85 per viewing effort, mostly due to large numbers of shorebirds using the newly exposed mud flats. Nekton density decreased from 100 m−2 to 38 m−2 after 1 year, probably because of the change from subtidal to mostly intertidal conditions and increased predation by birds. Initial results from monitoring demonstrate that restoration of the Potter Pond marsh complex improved tidal exchange, negatively impacted Phragmites, and increased bird use, resulting in an overall shift to a more natural functioning salt marsh system. This study also demonstrates that restoring even very small tide-restricted marshes can result in impressive ecological improvements.
The Potential of Eleutherine bulbosa in Inducing Apoptosis and Inhibiting Cell Cycle in Breast Cancer: A Network Pharmacology Approach and In Vitro Experiments

Objective: The objective of this study was to evaluate the potential and mechanisms of phytochemicals in Eleutherine bulbosa (EBE) in inducing apoptosis and inhibiting the cell cycle in breast cancer through a network pharmacology approach and in vitro validation. Methods: This research employed a literature review approach to identify active anti-cancer compounds and utilized a network pharmacology approach to predict the mechanisms of action of EBE compounds in breast cancer. In addition, in vitro experiments were conducted using MTT method to evaluate the effects of EBE on the cytotoxicity of T47D cells, and the flow cytometry method was employed to determine the impact of EBE on apoptosis and the cell cycle. Results: The network pharmacology analysis revealed that EBE had an impact on 42 genes involved in breast cancer, including 23 important target genes implicated in the pathophysiology of breast cancer. Pathway analysis using the KEGG database showed a close association between EBE and crucial signaling pathways in breast cancer, including P53 signaling pathway, MAPK signaling pathway, PI3K-Akt signaling pathway, apoptosis and cell cycle. In vitro experiments demonstrated that EBE exhibited moderate anti-cancer activity. Furthermore, EBE demonstrated significant potential in inducing apoptosis in breast cancer cells, with a percentage of apoptotic cells reaching 93.6%. Additionally, EBE was observed to disrupt the cell cycle, leading to a significant increase in the sub G1 and S phases, and a significant decrease in the G2-M and G1 phases. Conclusion: EBE has the potential to be an anti-cancer agent through various mechanisms, including apoptosis induction and cell cycle inhibition in breast cancer cells. These findings provide new insights into the potential of EBE as an alternative treatment for breast cancer.
Investigating the Spatiotemporal Summation of Perimetric Stimuli in Dry Age-Related Macular Degeneration

Purpose To measure achromatic spatial, temporal, and spatiotemporal summation in dry age-related macular degeneration (AMD) compared to healthy controls under conditions of photopic gaze-contingent perimetry. Methods Twenty participants with dry AMD (mean age, 74.6 years) and 20 healthy controls (mean age, 67.8 years) performed custom, gaze-contingent perimetry tests. An area-modulation test generated localized estimates of Ricco's area (RA) at 2.5° and 5° eccentricities along the 0°, 90°, 180°, and 270° meridians. Contrast thresholds were measured at the same test locations for stimuli of six durations (3.7–190.4 ms) with a Goldmann III stimulus (GIII, 0.43°) and RA-scaled stimuli. The upper limit (critical duration) of complete temporal summation (using the GIII stimulus) and spatiotemporal summation (using the RA stimuli) was estimated using iterative two-phase regression analysis. Results Median (interquartile range [IQR]) RA estimates were significantly larger in AMD participants (2.5°: 0.21 [0.09–0.41] deg2; 5°: 0.32 [0.15–0.65 deg2]) compared to healthy controls (2.5°: 0.08 [0.05–0.13] deg2; 5°: 0.15 [0.08–0.22] deg2) at all test locations (all P < 0.05). No significant difference in median critical duration was found in AMD participants with the GIII stimulus (19.6 [9.9–30.4] ms) and RA-scaled stimuli (22.9 [13.9–40.3] ms) compared to healthy controls (GIII: 17.0 [11.3–24.0] ms; RA-scaled: 22.4 [14.3–33.1] ms) at all test locations (all P > 0.05). Conclusions Spatial summation is altered in dry AMD, without commensurate changes in temporal summation. Translational Relevance The sensitivity of perimetry to AMD may be improved by utilizing stimuli that probe alterations in spatial summation in the disease.
Pollen beetle (Astylus atromaculatus)-associated gastroenteric disease in cattle: report of 6 natural outbreaks

Astylus atromaculatus is a pollen beetle native to South America, commonly found in crop flowers. Experimental intoxication of sheep and guinea pigs by this beetle resulting in fibrinonecrotizing enteritis has been reported. We describe here 6 natural outbreaks of intoxication in cattle associated with consumption of alfalfa (5 of 6) and mixed native (1 of 6) pastures heavily contaminated with A. atromaculatus. The outbreaks occurred during the summer (January–February) of 2023 in Argentina (n = 4) and Uruguay (n = 2), in beef cattle under extensive or semi-extensive rearing systems, with overall cumulative incidence and mortality of 22.3% and 17.8%, respectively. The main clinical signs included acute onset of anorexia, lethargy, hyperthermia, hindlimb weakness, reluctance to move, and diarrhea, for up to 15 d. In 2 outbreaks, sudden death was observed. Eight Hereford, Angus, and/or crossbreed heifers, cows, steers, and/or calves were autopsied. Gross and microscopic findings included multifocal necrosis with fibrinous pseudomembranes in the forestomachs and/or small and large intestines. Fragments or whole specimens of A. atromaculatus were identified in the ruminal content of all animals. Testing for multiple gastroenteric pathogens was negative as was testing of A. atromaculatus for cantharidin and batrachotoxin. GC-MS and LC-MS/MS performed on the beetles did not identify any known toxic compounds. Based on the exposure to A. atromaculatus–contaminated pasture, gross and microscopic lesions, and negative results of all testing for multiple gastroenteric pathogens, a diagnosis of intoxication by A. atromaculatus is proposed. Disease caused by A. atromaculatus consumption has not been reported previously in cattle, to our knowledge.