Miracle-dz/UniFAR-FTUs huggingface dataset:
Chilean experience using “Theranostics” for treating metastatic neuroendocrine tumors with [177Lu]Lu DOTA-TATE

Introduction: Well-differentiated, Neuroendocrine Tumors (NET) are highly heterogenic and slow-growing pathologies, characterized by unspecific symptomatology and elevated expression of somatostatin receptors (SSTR). Despite the high incidence of NETs, several patients are diagnosed in advance stages of the disease when surgery is insufficient to treat the pathology. Peptide receptor radionuclide therapy (PRRT) has emerged as a new state-of-the-art treatment for NET-patients in advanced stages. Results: In this retrospective study, between 2004 and 2018 a total of 66 patients with advanced-stage-NETs, refractory to other therapies, were treated with [177Lu]Lu DOTA TATE. At the end of the study, 56.1% of the patients were alive and the median overall survival for all patients in the study was 86.3 months. Patients that received doses ≥ 22.2 GBq showed increased overall survival (OS) in comparison with patients that received doses < 22.2 GBq (HR, 0.168; 95%CI 0.12- 0.99; p<0.001), adjusted by gender. Likewise, patients that received doses ≥29.6 GBq had an increased OS (HR, 0.42; 95%CI 0.19-0.94, p<0.05). Conclusion: Although several studies have shown that PRRT is an effective alternative for advanced NET, patients in South America have no regular access to PRRT. Our study proves that [177Lu]Lu-DOTA-TATE effectively increases the survival of patients with metastatic NET and provides an excellent alternative in terms of cost-efficiency for South American countries.
Denitrification Is the Main Nitrous Oxide Source Process in Grassland Soils According to Quasi‐Continuous Isotopocule Analysis and Biogeochemical Modeling

Isotopic composition of soil‐emitted nitrous oxide (N2O), especially the intramolecular distribution of 15N in N2O known as site preference (SP), can be used to track the two major N2O emitting soil‐processes nitrification and denitrification. Online analysis of SP in ambient air has been achieved recently, yet those approaches only allowed addressing large areas (footprints) on the basis of strong changes in surface atmospheric N2O concentrations. Here, we combined laser spectroscopy with automated static flux chambers to measure, for the first time, SP of low N2O fluxes with high sensitivity and temporal resolution and to explore its spatial variability. The measurements were then used to test the N2O isotope module SIMONE in combination with the biogeochemical model LandscapeDNDC to identify N2O source processes. End‐member mixing analysis of the data revealed denitrification as the predominant N2O source. This finding was independent of the soil water content close to the soil surface, suggesting that N2O production in the subsoil under high water‐filled pore space conditions outweighed the potential production of N2O by nitrification closer to the surface. Applying the SIMONE‐LandscapeDNDC model framework to our field site showed that the modeled SP was on average 4.2‰ lower than the observed values. This indicates that the model parameterization reflects the dominant N2O production pathways but overestimates the contribution of denitrification by 6%. Applying the stable isotope‐based model framework at other sites and comparing with other models will help identifying model shortcomings and improve our capability to support N2O mitigation from agricultural ecosystems.
Dynamics of rice sub-sector in Nepal: Research investment, production, and supply chain

Abstract. Rice is a major cereal crop that ensures food security and rural income generation in Nepal. The objectives of this study were to analyse the dynamics of the rice sub-sector from the perspective of production, research investment, and supply chain as expected outcomes are not yet achieved in spite of continuity in priority for research and production investment. Accordingly, this study was done by using secondary data covering 2000 to 2018 combined with a case study. For the case study, Morang, the district with the highest rice production was chosen. A random sample of 144 supply chain actors in which 100 rice producers, 10 collectors, 10 wholesalers, 7 millers, and 17 retailers were chosen from the list of the targeted population in each category. Findings revealed that rice production, productivity, and research investment were increasing at the rate of 1.25, 1.65, and 10.57 percent per annum, respectively. There was a strong positive link between research investment and production. Millers were the main value-adding actor. They have been getting the highest profit margin (31.5%) based on investing more (46.51%) in value-added activities. In contrast, farmers received a relatively low-profit margin (13.9%) with a 1.26 benefit-cost ratio. This was mainly due to the low adoption of improved production technology and weak horizontal coordination of rice producers. The percentage of food surplus households has increased, mainly due to the adoption of rice technologies generated by rice research programs, but this has not well reflected in terms of getting more profit margin by the rice-producing farmers. On the other hand, the research investment in rice was not consistent, and even not adequate for the required technology generation. Therefore, an increased investment could enhance the efficiency of generating technology packages, and implementation of effective extension services targeting the rice-growing farmers through increasing total factor productivity is crucial to increase the profit margin of rice producers. Moreover, with strengthened horizontal coordination among the major actors and with the increased investment in value-added activities in each stage of the supply chain based on consumer demand, increased profit margin for making the rice supply chain sustainable.
CARING NATIONAL IDENTITY THROUGH TEACHER CONTRIBUTIONS IN THE BORDER: PANCASILA ACTIONISTIC BASIC IMPLEMENTATION

This study looks at the phenomenon of Nationalism Education in various tribes in the Entikong region of Indonesia which borders Malaysia. The purpose of this study looks at the contribution of teachers in the scope of nationalization directly and factually, this nationalization is closely related to the implementation of the Pancasila axillary values as forming national identity. This research is focused on students and the practice of teachers who live in border areas. Retrieval of field data using descriptive qualitative methods using research designs and semi-ethnographic research procedures. The results of the field research indicate that the teacher carries out nationalization practices and campaigns through learning integration in the classroom and outside the classroom. There are 6 contributions seen in this study: teachers as instructors, teachers as managers, teachers as mentors, teachers as evaluators, teachers as members of professional organizations, and teachers as public relations specialists. This implication is expected to be able to strengthen the basis of national identity, especially in instilling Panacasila axiological values aimed at students at the Entikong border
Issues on Interbank Commodity Murabaha (CM) for Liquidity Management in Malaysia

Article history: Received 29 March 2020 Accepted 4 May 2020 Published 31 May 2020 Purpose: The objective of this research is to highlight issues and review the Interbank Commodity Murabahah (CM) practice as a tool of liquidity requirement from both the Shariah and industry's operational perspectives. Accordingly, this study seeks to analyze the structure and mechanism of CM as an instrument to meet the liquidity need of Islamic financial institutions and provides an opportunity for investments. In doing so, the paper seeks to review issues related to Shariah and operations in Islamic banking. Design/methodology/approach: By interviewing with Treasurers, Shariah Scholars and funding dealers of Islamic banks in Malaysia, the study evaluates reassessment on CM practices and operational issues concerning risk and compliance. The study focuses on the Islamic Treasury Division of Islamic banks in Malaysia. Findings: The findings of the study suggest that the two most significant issues in Islamic liquidity management of Islamic banks in Malaysia are i) resembling interest ii) nature of tradeability iii) structure of CM iv) the timing the transaction to be completed and v) the real brokerage cost involved in adopting the CM transactions. Research limitations/implications: The research proposes risk mitigation and enhanced Shariah compliance frameworks such as straight-through processing (STP) and commodity broker's standard guideline for Islamic banks to adopt CM practices. Practical implications: This study provides direction and guidance to the Islamic Commercial Banks, Commodity Brokers and regulator (BNM) involved in the banking system to reflect upon the importance to understand the issues and limitation of CM. By highlighting the importance of efficiency in terms of time and cost-saving together with Shariah issues, Islamic banks can design policies to enhance efficiency in order to either decide to maintain the adoption of CMP or to consider the proposed alternative. Social implications: Understanding the Shariah compliance and operational issues will enhance the integrity of Islamic banks, which is consistent with the Key Economic Growth Area of making Malaysia as International Islamic Financial Hub 2.0.
Do government expenditures and institutions drive growth? Evidence from developed and developing economies

Purpose – Most empirical studies on the government expenditure-economic growth nexus suggest a negative relationship between the size of the government expenditures and economic growth especially government consumption expenditures. Given these findings, the government should focus on development expenditures and reduce non-development expenditures for higher economic growth. However, the authors argue that this may not be the case, as government consumption expenditures along with better institutional quality promote growth via reduced corruption, reduction of political risks and good governance. The purpose of this study is to provide empirical evidences that both government consumption and development expenditure promote growth in the presence of better institutional quality. Design/methodology/approach – This paper re-examines the impact of government expenditures on growth whilst controlling institutional factors for a sample of 30 developed and 91 developing countries from 1984 to 2017. Government expenditure is segregated into consumption and development expenditures. Findings – The results are consistent with existing findings where government consumption expenditures have a negative effect on growth and government development expenditures contribute positively towards growth. However, when the authors conditioned government consumption expenditures with institutional variables, results suggest that in the presence of good institutions, both government consumption and development expenditures promote growth. Practical implications – The findings in this paper suggest that in the presence of good institutions, government consumption expenditures will contribute positively towards growth. The results are relatively consistent for both developing and developed economies, which suggests the importance of institutional factors leading to a parallel movement towards long run growth path. In other words, long run economic growth is driven by a similar institutional environment. Originality/value – Both developed and developing countries show similar reactions towards consumption and development expenditures. This indicates that despite the level of development, government expenditure.
Morphological and Molecular Analysis of Parasitoid Wasp, Cheiropachus quadrum (Hymenoptera: Chalcidoidea: Pteromalidae) Infesting Bark Beetles of Wide Host Trees

Cheiropachus quadrum Fabricius, 1787 (Hymenoptera: Chalcidoidea: Pteromalidae) is a Pteromalid parasitoid wasp infesting wood boring beetles predominantly family Scolytidae. Owing to their profound diversity and small size, their identification is bit tricky. The present study involves molecular analysis and morphological identification including new host record, distribution and key identification characters of species. Morphologically, Cheiropachus quadrum is easily characterised by its large propleura, maculate forewings and enlarged fore-femur. Cytochrome Oxidase gene 1 was used as marker gene for DNA barcoding purposes. Sequences edited and trimmed in BioEdit were submitted to GenBank for accession number generation. BLAST and MEGA tools were used for molecular analysis to confirm the corresponding taxonomy. Generated sequence was found to have no perfect identity matches and hence was morphologically confirmed and submitted as novel sequence to the database. Molecular characterisation involving phylogenetic analysis was performed with top hits from blast database using Neighbour Joining and Maximum Likelihood tree construction methods. It was found that the mean A+T content is 74.19% and estimated Transition/Transversion bias (R) is 0.71. Among the COI sequences, we found no overlap between the maximum K2P distance within species (0.02%) and minimum distance between species (3.6%). Phylogenetic analysis concluded DNA barcoding is helpful for identification of parasitoid species and complements morphological taxonomy for easy identification purposes.
The Economics of the Greenium: How Much is the World Willing to Pay to Save the Earth?

Sadly, not much. This paper provides a theoretical and empirical analysis of the greenium, the price premium the investor pays for green bonds over conventional bonds. We explain in simple economic terms why the price premium of a green bond essentially represents a combination of the non-pecuniary environmental benefit of the bond, as perceived by the investor, and the effective cost of issuing it, as measured by the additional issuing costs of the bond netted off a range of monetary and non-monetary benefits associated with the issuance. Our empirical model decomposes the greenium into a time-varying market component which is common to all green bonds and an idiosyncratic component which is specific to a certain green bond itself. Using the largest global green bond dataset compared to any previous studies, we find that the greenium on average amounts to, sadly, just over one basis point. However, it varies quite significantly among individual green bonds and our result suggests that a key factor underlying the variation is that they are subject to the risk of greenwashing to different extents.
Industry ""Fishing and Aquaculture"" as economic unit in the Baltic states and Finland

The research is devoted to the industry “Fishing and aquaculture” as an economic unit in Estonia, Finland, Latvia, Lithuania. With help of the input-output mathematical model, mathematical analysis, and adequate software we carry out the economical and technological analysis of the industry “Fishing and aquaculture”. The analysis is provided in the comparative aspect (comparing Estonia, Finland, Latvia, Lithuania) and in the dynamic aspect (using statistical information for 15 years). The statistical information in current research is the National Input-Output Tables for the 2000-2014 available via the World Input-Output Database. The original modification of the classical input-output model created by Jaunzems (2017), especially for World Input-Output Database’s information structure, allows us to calculate and to interpret line of economical and technological indicators: technological interindustry coefficients, Leontief inverse, monetary allocation coefficients, Ghosh inverse. All economical and technological interpretations of indicators are based on the mathematical connections resulted from the input-output model. According to the International Standard Industrial Classification of All Economic Activities, agriculture is divided into three industries “Crop and animal production, hunting and related service activities”, “Forestry and logging”, “Fishing and aquaculture”. The authors have already provided the comparative dynamic analysis of the industries’ “Crop and animal production, hunting and related service activities”, “Forestry and logging” economies (ERDEV: 2018, 2019). The systemized and founded conclusions about whole agriculture will be presented to the Agriculture Ministry of Latvia for the more detailed analysis and proper actions elaboration.
TURMERIC AS AN EFFECTIVE ALTERNATIVE TO ANTIBIOTICS FOR PROMOTING GROWTH OF JAPANESE QUAIL

Four groups of 360 quail at one day-old distributed at equal body weights and classed to four groups (control and three treatments) the first treatment antibiotic (control diet+ sub-therapeutic dose of avilamycin 8 mg/kg diet), the second and the third Turmeric powder 1% and 3% (control diet +1% and 3% turmeric powder) respectively, and used to test the possibility of using turmeric as natural alternative to antibiotics growth promoters on Japanese quail. The obtained results were summarized as follows: Growth performance was improved through appending quail diets with both 1 and 3% turmeric expressing as heavier LBW38d, BWG10-38, lower FI10-38, better FC10-38 and PI10-38 compared with either the avilamycin treatment or un supplemented group (control) and favoring the 1 % turmeric group which exceeded the 3% turmeric group, however adding turmeric did not affect the carcass, the antibiotic group had the highest dressed meat%. All serum biochemical indices tested at slaughter except HDL and Tri G significantly affected by either treatment or sex effects. The diets supplemented with turmeric showed lower total Cholesterol, LDL, RBS and AST than both avilamycin supplemented and un supplemented groups. Both antioxidant parameters and immune responses significantly affected by treatment effect. Conversely, sex had no effect on these parameters. The increase in turmeric rate of supplementation increased GPx and immune responses (IgG, IgA and IgM) and decreased TBAR. Useful intestinal bacteria (Lactobacillus) in growing quails significantly increased with added turmeric to quail diet and both Salmonella and E. coli (harmful intestinal bacteria) reduced significantly than the control group. The lowest intestinal bacteria counts either useful or harmful were obtained by the avilamycin supplemented group. In conclusion, supplementing quail grower diets with Turmeric1% may be act as an effective antibiotic alternative (avilamycin) for promoting quail growth.
Hereditary predisposition to breast cancer : evaluating the role of rare copy number variant, protein-truncating and missense candidate alleles

Breast cancer is the most common cancer among women, and inherited predisposition is one of the major recognized causes of increased breast cancer risk. Only about half of the hereditary cases are explained by mutations in the known susceptibility genes, including the DNA damage response genes BRCA1, BRCA2 and PALB2, leaving the majority still uncovered. Identification of the missing genetic predisposing factors is important for more effective diagnostics and counseling of the risk families, and also for better understanding of the etiology and cellular characteristics of breast cancer. The first aim of this study was to investigate the cancer associations of six rare germline copy number variant (CNV) deletions, which were previously identified in breast cancer patients by a genome-wide microarray approach. The second aim was to identify novel susceptibility alleles, both protein-truncating variants and missense mutations, by next-generation sequencing (NGS) of nearly 800 DNA damage response genes in 189 hereditary breast cancer patients. The cancerassociations of all selected candidate alleles (6 CNVs, 39 protein-truncating variants and 35 missense mutations) were studied by case-control approach using DNA samples from several hundred breast cancer patients and healthy controls. The prevalence of the studied CNVs did not significantly differ between the cases and controls, but when studying the associations with specific clinical parameters, deletion in the CYP2C19 gene showed enrichment in the breast cancer patients with hormonally triple-negative tumors (p=0.021). As CYP2C19 functions in estrogen metabolism, the results indicate that disturbance of hormonal balance due to enzyme defects may predispose specifically to the estrogen receptornegative subtype of breast cancer. Two protein truncating-variants, TEX15 c.7253dupT and FANCD2 c.2715+1G>A showed significant breast cancer association in the Northern Finnish cohort (p=0.018 and p=0.036, respectively). Similarly, two of the studied missense variants, RECQL p.Ile156Met (p=0.043) and POLG p.Leu392Val (p=0.010), were enriched in the breast cancer cases. Thus, this study provided novel connections between increased breast cancer risk and inherited mutations in TEX15, FANCD2 and POLG genes, and further supported the recently established role of RECQL as a breast cancer susceptibility gene.
Considerations on a Smart Strategy for Simultaneously Testing Multiple PCB Assemblies in Board Level Vibration

Board level vibration testing is an important characterization aspect that has to be considered during development and release of electronic components in applications involving harsh environments. Industrial reliability test standards prescribed by JEDEC recommend to stress a statistical representative sample size of at least 30 components. Consequently, the test execution time is undesirably long when testing all components sequentially. This paper provides a solution by developing a vibration test approach for simultaneously stressing multiple PCB assemblies. To start with, multiple boards are evaluated via vibrational spectrum analysis that is combined with a Finite Element Model (FEM) to calculate the strain at solder joint level. Limited variation is seen in calculated strain levels from PCB to PCB. This permits simultaneous testing of multiple PCB assemblies. Consequently, three test capacity expansion arrangements, namely One Dimensional (1D), Two Dimensional (2D: Stacked & Side by Side) & Three Dimensional (3D) test methods are evaluated. When comparing the investigated test extension strategies, it is found that test approach with stacked PCB levels alter the stress transferred to the component and can lead to a false reliability prediction. Depending upon the allowed mass load limit of the shaker system and stress levels involved, both 1D and 3D techniques can be used as complementary to one another. Outcomes of this study can further be used to provide guidance for future board level vibration test method.