Miracle-dz/UniFAR-FTUs huggingface dataset:
Post-mortem Gross Detection of Early Myocardial Infarction using Triphenyl Tetrazolium Chloride Test

Background: Ischemic heart disease is the leading cause of mortality in the world. More than 17 millionpeople die each year as a result of myocardial infarctions. Post-mortem histochemical detection of earlymyocardial infarction using 2,3,5-Triphenyl Tetrazolium Chloride (TTC) technique is based on the factthat ischemic myocardial cells lose their membrane integrity and release dehydrogenase enzyme into theblood stream, resulting in decrease or total depletion of these enzymes within the necrotic areas of themyocardium, and so, after immersion in TTC solution, enzyme depleted necrotic myocardium will notretain TTC dye and therefore appears as pale/yellow areas. Materials and Methods: This prospectivepostmortem study was conducted at Medicolegal Directorate in Baghdad city during the period fromMarch 2020 to December 2020. Myocardial specimens were isolated from 75 cases of sudden natural deathand were subjected to 1% TTC solution staining for gross assessment, and subsequently, tissue samples weretaken from suspected areas, processed and stained with H&E for histopathological evaluation and detectionof a possible acute myocardial infarction. Results: The mean age of studied cases was 50.3 ±12.57 years,ranging from 18 to 78 years, median age was 53 years. Males constituted the majority of cases (80%). Caseswere predominantly within 40-59 years age group (58%). The postmortem interval was ranging from 2 to17 hours (mean= 8.6 ±3.6 hours). After immersion in 1% TTC solution, 45 myocardial specimens showedmacroscopic pale/yellow areas which were indicative of acute myocardial infarcts within the ventricularwall, while histopathological examination of specimens revealed features of acute myocardial infarction(AMI) in 62 specimens. TTC stain was found to have a diagnostic sensitivity of 69.4% and specificity of76.9% in postmortem detection of AMI. Conclusion: The TTC technique allows identification of earlymyocardial necrosis. It’s practical, reliable and valid method that promises to be of considerable value. Itcan be used together with histopathology for postmortem detection of visually unapparent acute myocardialinfarcts.
A Transparadox Process of Decision Making

ABSTRACT Decision makers inevitably face a variety of tensions when managing strategic change. Research from organization and strategy perspectives, such as paradox and organizational learning, has offered useful but limited insight into the systematic mindset and thinking processes involved in decision making. We draw on theoretical and philosophical foundations of the transparadox perspective and related theories to build a dynamic process cycle of transparadoxical decision making. Three interrelated dimensions make up our model: (1) Transparadox Information Navigation, which includes embracing oppositional tendencies, syncretic focus, and creative transcendence; (2) Transparadox Contextual Consideration, characterized by prudent precision and recognizing the flux of temporality and spatiality; and (3) Transparadox Integration, which comprises design-type integration and exploration-type integration. We then present propositions on the interdependent and reinforcing mechanism among the three dimensions. Our work expands the paradox literature with specific mindset dimensions and constituent elements, connecting paradox research with the cognitive perspective by adding dynamic, cyclical processes to paradox cognition study. 摘要 在管理战略变革时，决策制定者不可避免地面临各种各样的张力。 以往在组织战略视角下做的研究，如悖论与组织学习，对决策制定的系统性心智模式和思维过程提供的见解有用但相当局限。 本文援引超悖论视角的理论与哲学基础以及其它相应理论，构建了决策制定的超悖论动态循环过程模型。 这一模型由三个互相关联的维度构成：（1）超悖论信息导航，包括主动采纳对立信息，聚焦于合成信息，和超越创生性三个要素；（2）超悖论情境考量，以谨慎精确和明辨时空为特征；（3）超悖论整合，由设计型整合与探索型整合组成。 本文进而提出论述这三个维度之间互相依赖和互相增固机制的理论命题。 本文不仅通过将具体的心智模式维度及其组成要素概念化而拓展了悖论研究，而且通过为悖论认知研究增添了动态、循环性过程，从而连接了悖论与认知视角的研究。
Isolation and Identification of Streptococcus pyogenes from Patients and Objects in Hospital Environment in Thi-Qarcity in Iraq

This study aimed to screen Streptococcus pyogenes in the hospital and investigate the incidence of thisbacteria. The genotypes of the S.pyogenes in the study samples will be determined using 16Sr RNA and somevirulence factors(emm, scpA, speA genes). The majority of the samples (74.1%) were isolated from patientsat the emergency room and (25.9%) were from hospital environment (objects). The current study showed thatthe total of 215 patients with pharyngitis were included 118 (55%) males higher than 97 (45%) females. Thepatients’ ages ranged from 2 to 62 years, which were divided into four categories. The majority of patients65 (30.1%) of patients from 3 to 6 years old, 54 (25%) of patients less than 3years, 51 (23.6%) from 7 to 11years old, and 46 (21.3%) more than 12years. Six isolates sent for sequencing were after that submission inNCBI-GenBank database. The results of nucleotide sequence alignment of the isolates revealed that thereare multiple point mutations, four of them appeared as a single nucleotide polymorphism (SNP) and twoappeared in duplicate. Polymorphic sites (Mutations) of 6 S.pyogenes isolates.
Recent Applications of Benchtop Nuclear Magnetic Resonance Spectroscopy

Benchtop nuclear magnetic resonance (NMR) spectroscopy uses small permanent magnets to generate magnetic fields and therefore offers the advantages of operational simplicity and reasonable cost, presenting a viable alternative to high-field NMR spectroscopy. In particular, the use of benchtop NMR spectroscopy for rapid in-field analysis, e.g., for quality control or forensic science purposes, has attracted considerable attention. As benchtop NMR spectrometers are sufficiently compact to be operated in a fume hood, they can be efficiently used for real-time reaction and process monitoring. This review introduces the recent applications of benchtop NMR spectroscopy in diverse fields, including food science, pharmaceuticals, process and reaction monitoring, metabolomics, and polymer materials.
Cellulose Oxygen Isotopes of Sphagnum and Vascular Plants in a Peat Core Reveal Climate Change in Northern Japan Over the Past 2,000 Years

The cellulose δ18O of plant tissues in peat is a potential climate proxy. However, understanding what is driving the shifts in δ18O of cellulose is required for its application. Here, we analyzed the δ18O values of Sphagnum and vascular plant cellulose, as well as the δ18O and δD values of pore water, in a 4‐m‐long peat core from the Bekanbeushi ombrotrophic bog to understand paleoclimatic changes in northern Japan over the past 2,000 years. The cellulose δ18O values of Sphagnum were lower than those of vascular plant tissues, although both draw water from the same layer. Whereas the cellulose δ18O values of Sphagnum more directly reflect those of precipitation, those of vascular plants become enriched through transpiration. Thus, the difference between vascular plants and Sphagnum (Δδ18Ovp–sp) is a potential proxy for relative humidity. Cellulose δ18O of Sphagnum revealed centennial variations with maxima around 800, 1300, and 1500 CE and minima around 500, 1000, 1700, and 1900 CE. The Δδ18Ovp–sp was inversely correlated with Sphagnum cellulose δ18O, indicating that the axis of summer westerlies was more frequently located to the north and the climate was moist in the former periods, whereas the axis of summer westerlies was generally located to the south and the climate was dry in the latter periods. These results suggest a warm and moist climate during the former periods due to frequent rainy summers driven by strong East Asian summer monsoon activity, and the opposite conditions in the latter periods.
PENERAPAN MEDIA PEMBELAJARAN BERBASIS AUGMENTED REALITY TERHADAP PENINGKATAN PEMAHAMAN MATEMATIS SISWA DITINJAU DARI GAYA BELAJAR

Penelitian ini bertujuan untuk meningkatkan kemampuan pemahaman matematika siswa melalui media pembelajaran berbasis Augmented Reality (AR) dalam hal gaya belajar. Penelitian ini merupakan penelitian eksperimen dengan desain penelitian yang digunakan dalam penelitian ini adalah The One-Group Pretest-Posttest. Populasi dalam penelitian ini adalah siswa kelas 5 SDN Cirendeu 01 sebanyak 202. Sampel penelitian ini adalah 30 siswa yang ditentukan melalui teknik purposive sampling. Dimana instrumen tes berbentuk tes kemampuan pemahaman matematis dan non-tes dengan angket gaya belajar dan observasi. Analisis data kemampuan pemahaman matematis siswa dilakukan dengan uji One Way Anova menggunakan SPSS 16. Hal ini dapat dilihat dari hasil uji hipotesis menggunakan uji ANOVA satu jalur dengan nilai signifikansi penggunaan AR sebesar 0,065. Oleh karena itu dapat disimpulkan bahwa media pembelajaran AR dapat meningkatkan kemampuan pemahaman matematika siswa tetapi tidak ada perbedaan dalam gaya belajar siswa
Improve Cross-Lingual Text-To-Speech Synthesis on Monolingual Corpora with Pitch Contour Information

Cross-lingual text-to-speech (TTS) synthesis on monolingual corpora is still a challenging task, especially when many kinds of languages are involved. In this paper, we improve the cross-lingual TTS model on monolingual corpora with pitch contour information. We propose a method to obtain pitch contour sequences for different languages without manual annotation, and extend the Tacotron-based TTS model with the proposed Pitch Contour Extraction (PCE) module. Our experimental results show that the proposed approach can effectively improve the naturalness and consistency of synthesized mixed-lingual utterances.
Chemical Changes and Optimisation of Acetous Fermentation Time and Mother of Vinegar Concentration in the Production of Vinegar-like Fermented Papaya Beverage

Fermentation has been long used as a method to produce beverage of various health benefits. In this research, ripe papaya (Carica papaya) was fermented through alcoholic fermentation using Saccharomyces cerevisiae, followed by acetous fermentation using Acetobacter spp. from mother of vinegar, to reduce wastage of this highly perishable Malaysian fruit. The papaya juice was pasteurised prior to the fermentation process. Optimisation of acetous fermentation was carried out using the response surface methodology (RSM) with central composite rotatable design (CCRD). Acetous fermentation time had shown significant effect on all the chemical characteristics while mother of vinegar concentration did not significantly effect on all the chemical characteristics. The vinegar-like fermented papaya beverage which was produced at the optimum point (Fermentation time = 70.80 h and concentration = 40% mother of vinegar) contained 0.37 ± 0.01% reducing sugar, 3.54 ± 0.36% ethanol, 2.46 ± 0.07% acetic acid, 327.89 ± 3.60 mg GAE/ L total phenolic, 2.32 ± 0.17 mg/100 mL ascorbic acid and 52.40 ± 0.23% mg AA/100 mL free-radical scavenging activity. In conclusion, vinegar-like fermented papaya beverage was successfully produced and its chemical compositions changed from papaya juice to wine and vinegar-like beverage with increased bioactive compounds and antioxidative activity.
Correlation between Nutritional Status, Energy Intake, and VO2Max Level in Female Futsal Players

The purpose of this study was to discover the correlation between nutritional status, intake of energy, and VO2Max level in female futsal players. The method used is quantitative correlation with the research design of Cross Sectional Study. The subjects in this study used female futsal players from Antartika Senior High School Sidoarjo with an age range of 15-18 years with a total of 30 people. Data were collected using measurements of height and weight, food recall 2x24 hours, and Multistage Fitness Test (MFT). Data analysis using Rank Spearman. Based on the results of the study, it can be concluded that there is a correlation between nutritional status and VO2Max ( r = -0.427 and p = 0.019) and there is a correlation between nutritional status and energy intake with values of r = 0.646 and p = 0.000. However, there is no correlation between energy intake and VO2Max ( r =0.080 and p = 0.674).
A Study on Physical and Physiological Impact of Polycystic Ovary Syndrome

Polycystic ovary syndrome is a relatively common hormonal disorder that causes a number of different symptoms in women of reproductive age. In such conditions, enlarged ovaries containing multiple small cysts (polycystic ovaries), are found. Although most women with PCOS have polycystic ovaries, some affected women do not. Common to all women with PCOS is an irregularity in menstrual cycle and the presence of excess male hormones (androgen). It disrupts the functioning of the reproductive organs that produce progesterone and estrogen, the hormones that regulate the menstrual cycle. A prospective observational study was carried out in 125 inpatients, after taking written informed consent from patients those who met the study criteria. A total of 125 patients were enrolled in the study, it was observed that 17.74% have experienced moderate depression, 18.54% patients experienced major irregular menstrual period problem, 2-25% of the patients were dealing with body weight, and 6.45% patients were identified that the growth of visible hair on the upper lip as a major problem. It was also found that 8.87% of patients experienced major menstrual cramps and patients were found worried about PCOS and hence disturbing their quality of life. Various long-term complication and co morbidities have been associated with PCOS and early diagnosed and therapeutic interventions are needed. PCOS is a chronic disease with manifestations across the life span and represents a major health and economic burden. Management should focus on support, education, addressing physiological factors and strongly emphasizing healthy lifestyle with targeted medical therapy as required. Addressing hyperandrogenism is clinically important and monitoring for and managing longer-term metabolic complications including dyslipidemia, IGT, DM2, cardiovascular risk factors, is crucial. Overall, further research is needed in this complex condition.
Epigenetic dysregulation in cardiovascular aging and disease

Cardiovascular disease (CVD) is the leading cause of mortality and morbidity for all sexes, racial and ethnic groups. Age, and its associated physiological and pathological consequences, exacerbate CVD incidence and progression, while modulation of biological age with interventions track with cardiovascular health. Despite the strong link between aging and CVD, surprisingly few studies have directly investigated heart failure and vascular dysfunction in aged models and subjects. Nevertheless, strong correlations have been found between heart disease, atherosclerosis, hypertension, fibrosis, and regeneration efficiency with senescent cell burden and its proinflammatory sequelae. In agreement, senotherapeutics have had success in reducing the detrimental effects in experimental models of cardiovascular aging and disease. Aside from senotherapeutics, cellular reprogramming strategies targeting epigenetic enzymes remain an unexplored yet viable option for reversing or delaying CVD. Epigenetic alterations comprising local and global changes in DNA and histone modifications, transcription factor binding, disorganization of the nuclear lamina, and misfolding of the genome are hallmarks of aging. Limited studies in the aging cardiovascular system of murine models or human patient samples have identified strong correlations between the epigenome, age, and senescence. Here, we compile the findings in published studies linking epigenetic changes to CVD and identify clear themes of epigenetic deregulation during aging. Pending direct investigation of these general mechanisms in aged tissues, this review predicts that future work will establish epigenetic rejuvenation as a potent method to delay CVD.
Effects of dietary macronutrients on the hepatic transcriptome and serum metabolome in mice

Dietary macronutrient composition influences both hepatic function and aging. Previous work suggested that longevity and hepatic gene expression levels were highly responsive to dietary protein, but almost unaffected by other macronutrients. In contrast, we found expression of 4005, 4232, and 4292 genes in the livers of mice were significantly associated with changes in dietary protein (5%–30%), fat (20%–60%), and carbohydrate (10%–75%), respectively. More genes in aging‐related pathways (notably mTOR, IGF‐1, and NF‐kappaB) had significant correlations with dietary fat intake than protein and carbohydrate intake, and the pattern of gene expression changes in relation to dietary fat intake was in the opposite direction to the effect of graded levels of caloric restriction consistent with dietary fat having a negative impact on aging. We found 732, 808, and 995 serum metabolites were significantly correlated with dietary protein (5%–30%), fat (8.3%–80%), and carbohydrate (10%–80%) contents, respectively. Metabolomics pathway analysis revealed sphingosine‐1‐phosphate signaling was the significantly affected pathway by dietary fat content which has also been identified as significant changed metabolic pathway in the previous caloric restriction study. Our results suggest dietary fat has major impact on aging‐related gene and metabolic pathways compared with other macronutrients.
Egypt’s image as a tourist destination: an exploratory analysis of DMO’s social media platforms

ABSTRACT The aim of this study is to provide a holistic analysis of Egypt’s image as a tourist destination on Social Media Platforms (SMPs). As a result, the promoted Destination Image (DI) of Egypt on SMPs was investigated, as well as the characteristics of the SMPs and how they are currently viewed by users (tourists). An exploratory analysis using a two-step quantitative approach was carried out. The findings show that the Egyptian SMPs failed to make a relative balance among the various key attractions to successfully deliver Egypt as a destination for all tastes. However, the validity of using the SMPs as marketing platforms can be improved if they are managed by a proficient team recognizing the value of the destination and being conscious of marketing techniques (e.g., the relevance of content, information depth and amount, and the ability to develop a relationship). This paper concentrates on Egypt’s image; however, the value of this study lies in being among the recent studies to assess both the projected and perceived destination image on social media platforms.
Conic Iterative Learning Control Using Distinct Data for Constrained Systems With State-Dependent Uncertainty

In batch processes, the ability to learn from previous process data results in high-value and batch-improved products. For batch processes with constraints and state-dependent uncertainty, this article presents a conic iterative learning control (ILC) approach, which uses cone theory to incorporate historical process data into optimization-based ILC design. The proposed conic ILC approach uses rank conditioning to select distinct data samples and conic mapping to map the data to the to-be-optimized control input variables, since adding all historical process data would be computationally intensive. Our method yields a tradeoff between learning ability from historical experience and computational efficiency from solving the optimization problem. Provable constraint satisfaction and robust stability are considered separately. To demonstrate the proven properties and effectiveness of the approach, we present a case study of the injection molding process.
ACHIEVEMENT GOALS AND EXTRANEOUS LOAD PREDICT GERMANE LOAD: THE MEDIATING EFFECTS OF ACHIEVEMENT EMOTIONS

Purpose – Achievement emotions have been shown to mediate the association between achievement goals and learning performance, but no research to date has tested whether there is a similar process in predicting germane cognitive load. Based on the control-value theory of academic emotions (Pekrun, 2006), the present study tested a model to determine whether goal orientation and extraneous load were mediated by achievement emotions in predicting germane load. Methodology – This survey study involved 487 voluntary university students (N = 487; 61% women; ages 17-23) who were enrolled in a statistics class and these study participants were selected using the cluster random sampling technique. They responded to three adapted scales which were translated into Bahasa Indonesia. The scales were, namely the Achievement Goal Questionnaire (AGQ), Achievement Emotions Questionnaire (AEQ), and Cognitive Load Questionnaire. Data were collected 20 minutes before the statistics class ended and the data was then analyzed using bootstraped bias corrected (CI = 95%; N=5000) in Structural Equation Modelling (SEM). Findings – The results of the structural equation modeling indicated that a mastery-approach goal was associated with higher germane load through higher enjoyment and lower anxiety, and a performance-avoidant goal was associated with lower germane load through higher anxiety. Moreover, extraneous load was negatively associated with germane load through enjoyment, but was positively associated with germane load through anxiety. Significance – These findings have implications in educational settings: for most students with a mastery-approach goal, and enjoyable activities are helpful, as with those that increase cognitive performance in processing learning information. The present research is the first study to show that achievement goals are linked to the capacity to process learning-relevant information, in part due to the emotions the student experiences in the learning environment.
Effect of the powerful plasticity of the tert‐butyl side chain on the conformational equilibrium of ascidiacyclamides

Ascidiacyclamide [cyclo(‐Ile1,5‐oxazoline2,6‐d‐Val3,7‐thiazole4,8‐)2] is a cytotoxic cyclic peptide from ascidian. Through structural analyses using monosubstituted analogues (Xaa1: Ala, 2‐aminobutyric acid, Val, cyclohexylglycine, and phenylglycine), we previously demonstrated the conformational equilibrium between its square and folded forms. As the bulkiness of the Xaa1 residue side chain was reduced, spontaneous folding was promoted, and the cytotoxicity decreased accordingly. In the present study, five disubstituted analogues in which a tert‐leucine residue (Tle) was incorporated at the 5‐position of the abovementioned monosubstituted analogues were synthesized, after which their structures were analyzed using X‐ray diffraction, circular dichroism (CD) spectral measurements, and 1H NMR‐based quantitative analysis. The side chains of the Tle and Ile residues are structural isomers of one another, and the Tle residue bearing the tert‐butyl group can be expected to play a role as a building block. In fact, peptides incorporating Tle5 exhibited much less spontaneous folding than their Ile5 counterparts in both crystal and solution. Increases in enthalpy and entropy due to the tert‐butyl group during the folding process resulted in increased conformational free energy (ΔG°). The powerful plasticity of the tert‐butyl group would stabilize the square form relating with cytotoxicity.
Consensus in possibly unbalanced switching networks with relative-state-dependent noises

This paper studies the consensus problem of discrete-time single-integrator multi-agent systems (MASs) with relative-state-dependent (RSD) noises in possibly unbalanced switching networks. By using a time-varying quadratic Lyapunov function, we prove that the mean square and almost sure consensus of the single-integrator MASs with RSD noises can always be achieved by adopting a constant gain protocol if the switching network is uniformly strongly connected. We also give the statistic property of the convergent random variable with respect to the initial state of the system. Simulation results are given to verify the correctness of the consensus conclusion.