Miracle-dz/UniFAR-FTUs huggingface dataset:
Quality Characteristics of Twelve Advanced Lines of Avena magna ssp. domestica Grown in Three Contrasting Locations in Morocco

The popularity of oats (Avena sativa) continues to increase in the cereal market due to their health benefits. The recent domestication of Avena magna, a Moroccan oat, presents an opportunity to enhance these benefits due to their higher nutritional composition. As the impact of microclimates on A. magna grain composition has not been explored, this study evaluates twelve A. magna ssp. domestica lines across three Moroccan locations, providing new data into microclimate effects on key grain characteristics. Significant variability is observed among lines and sites for nutrients, with mean protein, fat, and dietary fiber contents at 23.1%, 8.38%, and 7.23%, respectively. High protein levels, reaching 27.1% in Alnif and 26.5% in El Kbab, surpass the ‘Avery’ control (21.7% and 24.2%) in these environments. Groats from Bouchane exhibited elevated fat and fiber contents (10.2% and 9.94%) compared to the control (8.83% and 7.36%). While β-glucan levels remain consistent at 2.53%, a negative correlation between protein content, fat, and starch was observed. A. magna lines exhibited higher levels of iron (7.50 × 10−3 g/100 g DM) and zinc (3.40 × 10−3 g/100 g DM) compared to other cereals. Environmental conditions significantly influence grain quality, with El Kbab yielding higher protein and ash contents, as well as Bouchane having increased fat, fiber, and starch. Stability analysis indicates that fat content was more influenced by the environment, while 25% of protein variability is influenced by genetics. Lines AT3, AT5, AT6, AT13, and AT15 consistently exceeds both the mean for protein and fiber across all sites, emphasizing their potential nutritional value. This study highlights the potential of A. magna ssp. domestica to address nutritional insecurity, particularly for protein, iron, and zinc in domestic settings.
Multiscale Examination on the Temperature and Precipitation Series in Tianjin during 1921-2010

A multiscale examination of temperature and precipitation in Tianjin during 1921-2010 was performed using the EMD(Empirical Mode Decomposition) method. Moreover, power spectrum analysis was performed on the IMFs(Intrinsic Mode Functions) derived from EMD. This analysis indicates that the variations of the annual mean temperature are mainly characterized by high-frequency oscillations, with 2-3-year periods and quasi-5-year periods detected in the first two IMFs, and a long-term V-shaped variation in the trend component. In addition, interdecadal variations were detected in the fourth and fifth IMFs. The precipitation series are also mainly characterized by high-frequency oscillations, with periods of 2-3, 4.5, and 9 years detected in the first two IMFs. It is concluded that the interdecadal variations and the long-term trend are more apparent in the temperature series, and therefore have a much smaller contribution to precipitation variation.
Global grassland ecosystem modelling: development and test of ecosystem models for grassland systems

1 Natural Resource Ecology Laboratory, Colorado State University, Fort Collins, USA 2 Division of Life Sciences, King's College London, U K 3 Department of Vertebrate Zoology and Ecology, Moscow State University, Russia 4 Division of Water, Environment and Forest Technology, CSIR, Pretoria, South Africa 5 Climate System Modelling Program, NCAR, Boulder, USA 6 Laboratoire d'Ecologie, Ecole Normale Supérieure, Paris, France 7 Institute of Arctic and Alpine Research, University of Colorado, Boulder, USA 8 Centro de Botanica, Colegio de Postgraduados, Chapingo, Mexico 9 Faculty of Natural Resources, Prince of Songkla University, Hatyai, Thailand 10 Department of Botany, University of Nairobi, Kenya
The Impact of Mode of Delivery and Postpartum Conditions on Breastfeeding: A Cross-Sectional Study

Breast milk is the optimal and essential source of nutrients for babies. Many women, however, do not breastfeed or stop early after giving birth, often due to lack of support. For newborns delivered by caesarean section, there is often a delay, or no skin-to-skin contact after birth; thus, early breastfeeding is not achieved. Separation, complementary feeding or pacifier use also limits the mother’s ability to breastfeed. A quantitative, cross-sectional study was conducted. Sociodemographic data, the mode of delivery and postpartum circumstances, information on breastfeeding, and the method and duration of feeding were collected (n = 2008). Two-thirds of children born by caesarean section did not have skin-to-skin contact after birth (p < 0.001). Lack of rooming-in placement increased the incidence of more frequent complementary feeding (p < 0.001) and shortened the duration of exclusive breastfeeding (p < 0.001). The duration of breastfeeding may also be negatively affected by scheduled feeding (p = 0.007) and pacifier utilization (p < 0.001). The mode of delivery and postpartum circumstances directly affecting the mother and the newborn can affect the feasibility of breastfeeding and the duration of exclusive and partial breastfeeding. For positive breastfeeding outcomes, skin-to-skin contact immediately after birth, rooming-in and unrestricted, demand breastfeeding, as well as the avoidance of the use of pacifiers, are recommended.
Impact of Long-Term Care Service Quality on User Cooperation/Participation: Mediating Effect of Self-Determination

The purpose of this study is to determine whether home care service quality affects users’ voluntary cooperation/participation through self-determination. For this purpose, survey data from 358 long-term care service users in Korea were analyzed by applying a structural equation model. Data collection was conducted from February to March 2019. Data collection was conducted in February–March 2019. The results showed that home care quality did not directly affect users’ voluntary cooperation/participation in the service delivery process, and self-determination fully mediated the relationship between quality and cooperation/participation. Based on these results, the importance of providing appropriate information, reflecting users’ voices, and the attitude and role of experts was emphasized in order to promote user participation/cooperation through self-determination.
Physicochemical Features and Volatile Organic Compounds of Horse Loin Subjected to Sous-Vide Cooking

The purpose of this study was to evaluate the effect of temperature and time of sous-vide cooking method on the characteristics of Thoroughbred horse loin. Sliced portions (200 ± 50 g) were cooked by boiling (control) and sous-vide (65 and 70 °C for 12, 18, and 24 h). The samples were analyzed for proximate composition, pH, color, texture, microstructure, sodium dodecyl sulfate–polyacrylamide gel electrophoresis (SDS-PAGE), microbiology, volatile organic compounds (VOCs), nucleotide content, and fatty acids composition. The color analysis showed decreased redness at elevated temperatures. Improved tenderness, demonstrated by reduced shear force values (36.36 N at 65 °C for 24 h and 35.70 N at 70 °C for 24 h). The micrographs indicated dense fiber arrangements at 70 °C. The SDS-PAGE revealed muscle protein degradation with extended sous-vide cooking. The VOC analysis identified specific compounds, potentially distinctive markers for sous-vide cooking of horse meat including 1-octen-3-ol, decanal, n-caproic acid vinyl ester, cyclotetrasiloxane, octamethyl, and 3,3-dimethyl-1,2-epoxybutane. This study highlights the cooking time’s primary role in sous vide-cooked horse meat tenderness and proposes specific VOCs as potential markers. Further research should explore the exclusivity of these VOCs to sous-vide cooking.
Influence of Lymphatic, Microvascular and Perineural Invasion on Oncological Outcome in Patients with Neuroendocrine Tumors of the Small Intestine

Simple Summary Lymphatic (LI), microvascular (VI) and perineural invasion (PnI) have been determined as indicators for aggressive tumor behavior and worse outcome in many solid tumors. In neuroendocrine tumors of the small intestine (siNET), some prognosis-defining factors have been well established, but the role of LI, VI and PnI remains incompletely understood so far. The aim of our retrospective study was to elucidate the role of lymphatic, microvascular and perineural invasion in the oncological outcome in siNET. We found that lymphatic, microvascular and perineural invasion led to earlier disease recurrence and postoperative disease progression. We therefore promote the routine description of these histopathological parameters for considerations on adjuvant treatment and follow-up. Abstract For the histopathological work-up of resected neuroendocrine tumors of the small intestine (siNET), the determination of lymphatic (LI), microvascular (VI) and perineural (PnI) invasion is recommended. Their association with poorer prognosis has already been demonstrated in many tumor entities. However, the influence of LI, VI and PnI in siNET has not been sufficiently described yet. A retrospective analysis of all patients treated for siNET at the ENETS Center of Excellence Charité–Universitätsmedizin Berlin, from 2010 to 2020 was performed (n = 510). Patients who did not undergo primary resection or had G3 tumors were excluded. In the entire cohort (n = 161), patients with LI, VI and PnI status had more distant metastases (48.0% vs. 71.4%, p = 0.005; 47.1% vs. 84.4%, p < 0.001; 34.2% vs. 84.7%, p < 0.001) and had lower rates of curative surgery (58.0% vs. 21.0%, p < 0.001; 48.3% vs. 16.7%, p < 0.001; 68.4% vs. 14.3%, p < 0.001). Progression-free survival was significantly reduced in patients with LI, VI or PnI compared to patients without. This was also demonstrated in patients who underwent curative surgery. Lymphatic, vascular and perineural invasion were associated with disease progression and recurrence in patients with siNET, and these should therefore be included in postoperative treatment considerations.
Association between Beverage Consumption and Sleep Quality in Adolescents

The objective of this study was to verify if the consumption of different beverages (such as water, 100% pure fruit juice, and sugar-sweetened beverages (SSBs)) is associated with adolescents’ sleep quality. French-speaking adolescents were recruited in person and online throughout the province of Québec (Canada) from the end of March to early July 2023. Beverage consumption and sleep quality were measured using French versions of validated questionnaires specifically designed for adolescents. A total of 218 adolescents (14–17 years; 55.5% female) completed the online survey. Among caffeinated SSBs, energy drink (rs = −0.16; p = 0.0197) and sugar-sweetened coffee (rs = −0.33; p < 0.0001) intake was correlated with adolescents’ sleep quality. Energy drink consumption (β = −0.0048; p = 0.0005) and being male (β = 0.6033; p < 0.0001) were associated with adolescents’ sleep quality. There was an interaction between sugar-sweetened coffee intake and biological sex that was associated with adolescents’ sleep quality (p = 0.0053). Sugar-sweetened coffee consumption was correlated with adolescent girls’ abilities to go to bed (rs = −0.21; p = 0.0203) and fall asleep (rs = −0.28; p = 0.0020), while in boys, it was only significantly correlated with their abilities to go to bed (rs = −0.27; p = 0.0069). Public health interventions aimed at adolescent boys should primarily target lowering energy drink consumption, while those aimed at girls should prioritize sugar-sweetened coffee intake to possibly improve their sleep quality.
Parsimonious Scenario for the Emergence of Viroid-Like Replicons De Novo

Viroids are small, non-coding, circular RNA molecules that infect plants. Different hypotheses for their evolutionary origin have been put forward, such as an early emergence in a precellular RNA World or several de novo independent evolutionary origins in plants. Here we discuss the plausibility of de novo emergence of viroid-like replicons by giving theoretical support to the likelihood of different steps along a parsimonious evolutionary pathway. While Avsunviroidae-like structures are relatively easy to obtain through evolution of a population of random RNA sequences of fixed length, rod-like structures typical of Pospiviroidae are difficult to fix. Using different quantitative approaches, we evaluate the likelihood that RNA sequences fold into a rod-like structure and bear specific sequence motifs facilitating interactions with other molecules, e.g. RNA polymerases, RNases and ligases. By means of numerical simulations, we show that circular RNA replicons analogous to Pospiviroidae emerge if evolution is seeded with minimal circular RNAs that grow through the gradual addition of nucleotides. Further, these rod-like replicons often maintain their structure if independent functional modules are acquired that impose selective constraints. The evolutionary scenario we propose here is consistent with the structural and biochemical properties of viroids described to date.
The impacts of public participation in area-based urban regeneration: a case study of the London Borough of Newham

Public participation is a key part of the urban regeneration policies in Britain strongly promoted by the New Labour government. The main aim of this study is to investigate the impacts of public participation in area-based urban regeneration where poverty and multiple deprivation are prevalent. The case study area is the London Borough of Newham, a borough that benefits from many of these policy initiatives for a variety of aspects of social, economic and environmental regeneration. Following the completion of their budgeted project life, however, the outcomes of many of the regeneration initiatives in Newham and elsewhere are not always sustainable. One of the many possible explanations for the failure of initiatives to secure a long-term improvement in the quality of life of the residents is the lack of ownership by local people which is a consequence of nonor little public participation in the regeneration process. This often reflects the almost non-existence of social networks among communities undergoing regeneration and the lack of empowerment of residents from the outset and throughout the lifetime of projects. The thesis argues that a good stock of social networks and well developed community empowerment will lead to a higher level of participation that could help regeneration initiatives to become more sustainable. It is based on a programme of research that used a range of mixed methods, including surveys, interviews and observation, to investigate the nature of participation in Newham regeneration settings. The findings explore the extent of participation and consider the views of a range of stakeholders on its role in the regeneration process. As well as critically evaluating current Newham regeneration initiatives in relation to the degree to which they meaningfully encourage public participation, the study also sets out to develop ideal models of participation. It explores different approaches to engaging with local people and social networks at neighbourhood level, and emphasises to the importance of evaluating regeneration in relation to its participatory goals. The thesis concludes by reiterating the importance of a meaningful public participation in the national and local policy regimes. It also sets out the significance of the research in understanding the role of participation in Britain’s area based urban regeneration strategies.
SMC5/6 Promotes Replication Fork Stability via Negative Regulation of the COP9 Signalosome

It is widely accepted that DNA replication fork stalling is a common occurrence during cell proliferation, but there are robust mechanisms to alleviate this and ensure DNA replication is completed prior to chromosome segregation. The SMC5/6 complex has consistently been implicated in the maintenance of replication fork integrity. However, the essential role of the SMC5/6 complex during DNA replication in mammalian cells has not been elucidated. In this study, we investigate the molecular consequences of SMC5/6 loss at the replication fork in mouse embryonic stem cells (mESCs), employing the auxin-inducible degron (AID) system to deplete SMC5 acutely and reversibly in the defined cellular contexts of replication fork stall and restart. In SMC5-depleted cells, we identify a defect in the restart of stalled replication forks, underpinned by excess MRE11-mediated fork resection and a perturbed localization of fork protection factors to the stalled fork. Previously, we demonstrated a physical and functional interaction of SMC5/6 with the COP9 signalosome (CSN), a cullin deneddylase that enzymatically regulates cullin ring ligase (CRL) activity. Employing a combination of DNA fiber techniques, the AID system, small-molecule inhibition assays, and immunofluorescence microscopy analyses, we show that SMC5/6 promotes the localization of fork protection factors to stalled replication forks by negatively modulating the COP9 signalosome (CSN). We propose that the SMC5/6-mediated modulation of the CSN ensures that CRL activity and their roles in DNA replication fork stabilization are maintained to allow for efficient replication fork restart when a replication fork stall is alleviated.
Microbiome and Prostate Cancer: Emerging Diagnostic and Therapeutic Opportunities

This review systematically addresses the correlation between the microbiome and prostate cancer and explores its diagnostic and therapeutic implications. Recent research has indicated an association between the urinary and gut microbiome composition and prostate cancer incidence and progression. Specifically, the urinary microbiome is a potential non-invasive biomarker for early detection and risk evaluation, with altered microbial profiles in prostate cancer patients. This represents an advancement in non-invasive diagnostic approaches to prostate cancer. The role of the gut microbiome in the efficacy of various cancer therapies has recently gained attention. Gut microbiota variations can affect the metabolism and effectiveness of standard treatment modalities, including chemotherapy, immunotherapy, and hormone therapy. This review explores the potential of gut microbiome modification through dietary interventions, prebiotics, probiotics, and fecal microbiota transplantation for improving the treatment response and mitigating adverse effects. Moreover, this review discusses the potential of microbiome profiling for patient stratification and personalized treatment strategies. While the current research identifies the pivotal role of the microbiome in prostate cancer, it also highlights the necessity for further investigations to fully understand these complex interactions and their practical applications in improving patient outcomes in prostate cancer management.
Bergamot Byproducts: A Sustainable Source to Counteract Inflammation

Chronic inflammation is the result of an acute inflammatory response that fails to eliminate the pathogenic agent or heal the tissue injury. The consequence of this failure lays the foundations to the onset of several chronic ailments, including skin disorders, respiratory and neurodegenerative diseases, metabolic syndrome, and, eventually, cancer. In this context, the long-term use of synthetic anti-inflammatory drugs to treat chronic illnesses cannot be tolerated by patients owing to the severe side effects. Based on this, the need for novel agents endowed with anti-inflammatory effects prompted to search potential candidates also within the plant kingdom, being recognized as a source of molecules currently employed in several therapeutical areas. Indeed, the ever-growing evidence on the anti-inflammatory properties of dietary polyphenols traced the route towards the study of flavonoid-rich sources, such as Citrus bergamia (bergamot) and its derivatives. Interestingly, the recent paradigm of the circular economy has promoted the valorization of Citrus fruit waste and, in regard to bergamot, it brought to light new evidence corroborating the anti-inflammatory potential of bergamot byproducts, thus increasing the scientific knowledge in this field. Therefore, this review aims to gather the latest literature supporting the beneficial role of both bergamot derivatives and waste products in different models of inflammatory-based diseases, thus highlighting the great potentiality of a waste re-evaluation perspective.
Magnesium and Vascular Calcification in Chronic Kidney Disease: Current Insights

Magnesium (Mg) plays crucial roles in multiple essential biological processes. As the kidneys are the primary organ responsible for maintaining the blood concentration of Mg, people with chronic kidney disease (CKD) may develop disturbances in Mg. While both hyper- and hypomagnesemia may lead to adverse effects, the consequences associated with hypomagnesemia are often more severe and lasting. Importantly, observational studies have shown that CKD patients with hypomagnesemia have greater vascular calcification. Vascular calcification is accelerated and contributes to a high mortality rate in the CKD population. Both in vitro and animal studies have demonstrated that Mg protects against vascular calcification via several potential mechanisms, such as inhibiting the formation of both hydroxyapatite and pathogenic calciprotein particles as well as limiting osteogenic differentiation, a process in which vascular smooth muscle cells in the media layer of the arteries transform into bone-like cells. These preclinical findings have led to several important clinical trials that have investigated the effects of Mg supplementation on vascular calcification in people with CKD. Interestingly, two major clinical studies produced contradictory findings, resulting in a state of equipoise. This narrative review provides an overview of our current knowledge in the renal handling of Mg in health and CKD and the underlying mechanisms by which Mg may protect against vascular calcification. Lastly, we evaluate the strength of evidence from clinical studies on the efficacy of Mg supplementation and discuss future research directions.
The Differentiation of Point Symbols using Selected Visual Variables in the Mobile Augmented Reality System

On the basis of initial studies devoted to a better understanding of how the public user (a pedestrian in the city) perceives cartographic symbols in the mobile augmented reality system, we present an attempt to determine the threshold values of differentiation for three visual variables. The variables of size, transparency, and focus were implemented into image point symbols representing five types of objects. The set of symbols was designed in accordance with the rules of cartographic design taking into consideration an analysis of 19 professional tourist works. The symbols were presented on the screen of a mobile device in a system imitating the augmented reality system against four different backgrounds: white, a wall, and two typical urban landscapes. The results of an internet survey conducted using a tablet at four locations in Poznan (Poland) allowed us to determine the following: threshold differentiation values for the analysed variables, indication of the dependence on the type of background displayed on the mobile device in augmented reality, and the advantage of using a combination of visual variables.