Miracle-dz/UniFAR-FTUs huggingface dataset:
Prevalence of High-Risk Prostate Cancer Metastasis to Cloquet’s Ilioinguinal Lymph Node

Purpose: Cloquet’s node, located at the junction between the deep inguinal nodes and the external iliac chain, is easily accessible and commonly excised during pelvic lymph node dissection for prostate cancer. However, we hypothesize that Cloquet’s node is not part of lymphatic metastatic spread of prostate cancer. Materials and Methods: Between September 2016 and June 2019, 105 consecutive patients with high-risk prostate cancer (cT3a or Grade Group 4/5, or prostate specific antigen >20 ng/ml) underwent a laparoscopic radical prostatectomy and pelvic lymph node dissection. First, Cloquet’s node was identified, retrieved and submitted separately to pathology as right and left Cloquet’s node. Next, a pelvic lymph node dissection was completed including the external iliac, obturator fossa and hypogastric nodal packets. Each lymph node was cut into 3 mm slices which were separately embedded in paraffin, stained with hematoxylin and eosin, and examined microscopically. Results: The final analysis included 95 patients. In this high-risk population, the median number of nodes removed was 22 (IQR 18–29); 39/95 patients (41%) had lymph node metastasis. The median number of Cloquet's nodes removed was 2 (IQR 2–3). Cloquet’s node was negative in all but 1 patient (1.1%), who had very high-risk features and high metastatic burden in the lymph nodes. Conclusions: In high-risk prostate cancer, metastasis to the ilioinguinal node of Cloquet is rare. Given this low prevalence, Cloquet’s node can be safely excluded from the pelvic lymph node dissection template.
Bidirectional difference locating and semantic consistency reasoning for change captioning

Change captioning is an emerging task to describe the changes between a pair of images. The difficulty in this task is to discover the differences between the two images. Recently, some methods have been proposed to address this problem. However, they all employ unidirectional difference localization to identify the changes. This can lead to ambiguity about the nature of the changes. Instead, we propose a framework with bidirectional difference localization and semantic consistency reasoning to describe the image changes. First, we locate the changes in the two images by capturing bidirectional differences. Then we design a decoder with spatial‐channel attention to generate the change caption. Finally, we introduce semantic consistency reasoning to constrain our bidirectional difference localization module and spatial‐channel attention module. Extensive experiments on three public data sets show that the performance of our proposed model outperforms the state‐of‐the‐art change captioning models by a large margin.
Formation and Investigation of Mechanical, Thermal, Optical and Wetting Properties of Melt-Spun Multifilament Poly(lactic acid) Yarns with Added Rosins

One method for adding enhancing properties to textile materials is the insertion of natural ingredients into the textile products during the manufacturing or finishing process. The aim of this research is to investigate the formation of biodegradable melt-spun multifilament Poly(lactic acid) (PLA) yarns with different contents (i.e., 5%, 10%, and 15%) of natural material–rosin, also known as colophony. In this study, multifilament yarns were successfully formed from PLA and a natural substance–pine rosin by melt-spinning them at two different draw ratios (i.e., 1.75 and 2.75). The results indicated that a 1.75 draw ratio caused the formation of PLA and PLA/rosin yarns that were brittle. The presence of rosin (i.e., 5% and 10%) in multifilament yarns decreased the mechanical properties of the PLA/rosin melt-spun multifilament yarns’ tenacity (cN/tex), breaking tenacity (cN/tex), and tensile strain (%) and elongation at break (%) and increased absorbance in the entire UV region spectra. In addition, the melting point and degree of crystallinity decreased and there was an increase in the wetting angle compared with pure PLA multifilament. The investigation of melt-spun yarns with Raman spectroscopy proved the presence of rosin in PLA melt-spun yarns.
The effects of oral magnesium supplementation on glycaemic control in patients with type 2 diabetes: a systematic review and dose–response meta-analysis of controlled clinical trials

Abstract The current systematic review and meta-analysis were conducted to evaluate the effects of oral Mg supplementation on glycaemic control in type 2 diabetes mellitus (T2DM) patients. Related articles were found by searching the PubMed, SCOPUS, Embase and Web of Science databases (from inception to 30 February 2020). A one-stage robust error meta-regression model based on inverse variance weighted least squares regression and cluster robust error variances was used for the dose–response analysis between Mg supplementation and duration of intervention and glycaemic control factors. Eighteen eligible randomised clinical trials were included in our final analysis. The dose–response testing indicated that the estimated mean difference in HbA1c at 500 mg/d was −0·73 % (95 % CI: −1·25, −0·22) suggesting modest improvement in HbA1c with strong evidence (P value: 0·004). And in fasting blood sugar (FBS) at 360 mg/d was −7·11 mg/dl (95 % CI: −14·03, −0·19) suggesting minimal amelioration in FBS with weak evidence (P value: 0·092) against the model hypothesis at this sample size. The estimated mean difference in FBS and HbA1c at 24 weeks was −15·58 mg/dl (95 % CI: −24·67, −6·49) and −0·48 (95 % CI: −0·77, −0·19), respectively, suggesting modest improvement in FBS (P value: 0·034) and HbA1c (P value: 0·001) with strong evidence against the model hypothesis at this sample size. Oral Mg supplementation could have an effect on glycaemic control in T2DM patients. However, the clinical trials so far are not sufficient to make guidelines for clinical practice.
SoC test schedule based on TCG and simulated annealing algorithm

Many novel testing structures for system-on-a-chip are proposed for decreasing testing cost and facilitating test reuse.For the simplicity of Test Collar and test rail,they are widely used in today’s SoC test solutions.But the test scheduling problem of test rail and collar is very complex,and it is hard to get the optimum solution.A novel description of test schedule based on transitive closure graph is proposed in this paper,and it is suitable for combinational optimization.Simulated annealing algorithm is used to get the optimum test solution,and it demonstrates its advantage over other solution published recently in test time.
Seasonal variation in paediatric orthopaedic trauma Patients – A single centre experience from Turkey

Purpose It is known that the incidence of paediatric orthopaedic trauma peaks in the summer months as a result of increased and uncontrolled physical activity. The aim of this study was to review the experience of a single centre with paediatric orthopaedic traumas and determine the relationship between the severity and the variations in the incidence of traumas in relation to the seasons and temperatures during the study period. Materials and Methods A single institutional review of the historical data of all patients aged 0–16 years who presented for orthopaedic trauma between January 2018 and December 2020 in the emergency department of Level 1 tertiary orthopaedic trauma centre was conducted. 65,182 paediatric orthopaedic trauma cases had been retrieved from the hospital data base during the 3 -year study period. We classified the traumas according to the variants of the patients’ and by holidays, seasons, school days and weekends, months and in which part of the body it occurred. Results After excluding the summer vacation, 77% of paediatric orthopaedic trauma patients attended to the hospital on weekdays and 23% on weekends. While it was observed that hot weather had a statistically positive effect on trauma attendance, rainy weather had an negative effect (p < 0.05). Trauma attendances were found to be statistically higher in summer months, except for injuries that may occur with indoor activities such as metacarpal fracture, phalanx fracture and pulled elbow (p < 0.05). Conclusion Orthopaedic trauma at a Level 1 tertiary health care trauma center do vary significantly with the weather and are highest in the summer season. Therefore, it should focus more attention on preventive strategies for paediatric trauma in the summer season.
A standardized multi‐method survey to enhance characterization of riparian invertebrate communities

Riparian invertebrate communities are species rich, but variability in sampling methods hampers assessment of their distributions and inference of the quality of their habitats. To reduce this variability, a standardized, multi‐method survey protocol was recently developed. Here, riparian beetle community surveys conducted before and after the protocol's introduction were used to evaluate its effectiveness in characterizing communities and in limiting variability among surveys. Use of the standardized protocol reduced variability in sampling effort, and this had a limited effect on estimates of taxonomic richness. Surveys using the protocol captured significantly more species than surveys done before its introduction, evidencing the benefits of standardized multi‐method survey protocols. Our study highlights that standardized multi‐method survey protocols may enable identification and prioritization of sites requiring management to improve habitat quality. As such, we recommend the integration of such protocols into monitoring programmes, to enhance protection of biodiverse invertebrate communities in vulnerable riparian habitats.
The developmental origin and the specification of the adrenal cortex in humans and cynomolgus monkeys

Development of the adrenal cortex, a vital endocrine organ, originates in the adrenogonadal primordium, a common progenitor for both the adrenocortical and gonadal lineages in rodents. In contrast, we find that in humans and cynomolgus monkeys, the adrenocortical lineage originates in a temporally and spatially distinct fashion from the gonadal lineage, arising earlier and more anteriorly within the coelomic epithelium. The adrenal primordium arises from adrenogenic coelomic epithelium via an epithelial-to- mesenchymal-like transition, which then progresses into the steroidogenic fetal zone via both direct and indirect routes. Notably, we find that adrenocortical and gonadal lineages exhibit distinct HOX codes, suggesting distinct anterior-posterior regionalization. Together, our assessment of the early divergence of these lineages provides a molecular framework for understanding human adrenal and gonadal disorders. One Sentence Summary Specification of the adrenal cortex occurs in adrenogenic coelomic epithelium independent of gonadogenesis in humans and cynomolgus monkeys
Improved Resilience and Academics Following A School-based Resilience Intervention: A Randomized Controlled Trial

ABSTRACT Enhancing resilience is valuable to youth from economically marginalized communities given that they often face greater challenges and hardships than their peers from more affluent communities. Efforts to increase resilience skills in these youth are hampered because they disproportionately encounter barriers in access to mental health interventions. Implementing school-based services may be optimal to address these inequalities. This project explores the effectiveness of a school-based group intervention (the Resilience Builder Program®) related to resilience and academic functioning in a sample of children from economically marginalized communities. Students (N = 169) with social-emotional difficulties were recruited from five elementary schools and randomly assigned to participate in the Resilience Builder Program® (RBP) immediately or following a semester delay. Participants, their parents, and teachers completed measures of resilience (BASC-2, RSCA) and academic functioning (ACES). Results found a significant relationship between resilience and stronger academic functioning (i.e., engagement and motivation). RBP participants, their parents, and teachers reported greater increases in resilience compared to the delay group. Teachers reported significant increases in students’ study skills, academic engagement, interpersonal skills, and academic motivation compared to the delay group. RBP participants reported significantly greater study skills and academic engagement, compared to the delay group. Findings indicate school-based RBP effectively promotes resilience skills and academic functioning in children who often face significant barriers to accessing mental health care.
Supply Chain Disruptions and Consumer Behavior Change from COVID-19: Empirical Evidence and Long-Term Implications for Supermarkets in the UK

The COVID-19 pandemic has caused disruptions to supply chains and changes to consumer behaviours around the world. This research looks at those two aspects within supermarket retail chains in England between now and the time the first lockdown ended. It also explores the changes supermarket supply chains are making for the near future as a result of the pandemic. Both of these areas, to the best knowledge of the authors have not been covered so far in literature. The research followed a qualitative approach with interviews conducted of supply chain professionals and store managers belonging to large supermarket chains. A thematic analysis was performed revealing the main themes discussed in interviews. The results imply supply-side disruptions have been more significant than demand-side disruptions within the past year or so. Moreover, some indications are given regarding the recent developments supermarket chains are making for the future to be better equipped to handle any new lockdowns or pandemics. The research has informed theory and practice that supply-side issues are the bigger concern currently in England and has mentioned a few ways to manage them. Additionally, by introducing key developments for the future, the research has highlighted the importance for other grocery retailers to think of ways to transform their supply chain to not only withstand disruptions, but also compete in the grocery retail space in the longer-term.
Strategies for Incorporating Culture into Psychosocial Interventions for Youth of Color

ABSTRACT This review summarized the literature on psychosocial interventions for youth of color. Ninety-three journal articles of randomized clinical trials, with samples comprising youth of color, published between 1974 and 2018 were coded for sample characteristics, intervention characteristics, and strategies for incorporating culture into psychotherapy. Results found 69 psychosocial interventions to be efficacious for youth of color; 32% of these psychosocial interventions included a strategy for incorporating culture into psychotherapy. The evidence base was largest for Black and Hispanic/Latinx populations and for psychosocial interventions targeting disruptive behavior problems. The most common strategies for incorporating culture into treatment among effective psychosocial interventions were employing procedures for addressing cultural context and including providers with awareness and knowledge of the client’s culture. The inclusion of strategies for incorporating culture was not associated with treatment efficacy. Findings from this review highlight the laudable efforts that have been made to identify efficacious psychosocial interventions for youth of color and illuminate remaining gaps in the evidence base (e.g., efficacious psychosocial interventions for Asian, Native American and Alaska Native, and Native Hawaiian and Pacific Islander youth). Findings also emphasize the nuance of providing effective mental health services that are compatible with client’s cultural worldviews, values, and practices and allude to the promise of decision support tools to help providers determine whether, when, and how to culturally tailor their psychotherapy with youth of color.
Students’ perceptions of self-assessment and their approaches to learning in university mathematics

This study aims at better understanding of the use of self-assessment to support high-achieving students in first-year university mathematics. The students, who had not previously self-assessed their skills and knowledge in mathematics, were given two self-assessment exercises during a calculus course: they assessed their prior knowledge and learning goals in the beginning of the course and the quality of their learning outcomes in the end. Their approaches to learning and perceptions of self-assessment were studied with questionnaires in the beginning and at the end of the course. The students felt that they were able to assess their performance and that self-assessment exercises helped them to learn. Their self-ratings agreed well with the teacher's grading. Self-assessment was implemented to support novice students to adopt a deep approach to learning, and the results showing a statistically significant decrease in unreflective approach give an encouraging signal.
Pathogenic signaling in multiple myeloma.

Multiple myeloma is a common hematological malignancy of plasma cells, the terminally differentiated B cells that secrete antibodies as part of the adaptive immune response. Significant progress has been made in treating multiple myeloma, but this disease remains largely incurable, and most patients will eventually relapse and become refractory to further therapies. Moreover, a portion of patients with multiple myeloma are primary refractory to all treatments from their initial diagnosis, and no current therapeutic approaches can help. Therefore, the task remains to advance new therapeutic strategies to help these vulnerable patients. One strategy to meet this challenge is to unravel the complex web of pathogenic signaling pathways in malignant plasma cells and use this information to design novel precision medicine strategies to assist these patients most at risk.
Real-World Treatment Selection Factors and 7-Year Clinical Outcomes between Percutaneous Coronary Intervention and Coronary Artery Bypass Graft Surgery in Left Main Disease

Background: The decision-making factors and long-term clinical outcomes between PCI and CABG in left main (LM) disease are still not well defined in the real world. Methods: We evaluated consecutive patients (n = 230) with LM disease either treated by PCI (n = 118) or CABG (n = 112). The primary endpoint was major adverse cardiovascular events (MACE), defined as a composite of cardiac death, spontaneous myocardial infarction (MI), stroke, and target vessel revascularization (TVR) for 7 years. Results: In the multivariate-adjusted analysis, the presence of intermediate EuroSCORE II and high SYNTAX scores predisposed to CABG. Isolated LM disease was associated with receiving PCI. The PCI group had a similar rate of MACE (HRadj 0.97, 95% CI [0.48–1.94], p = 0.92) and a lower tendency of hard MACE (HRadj 0.49, 95% CI [0.22–1.07], p = 0.07) compared to the CABG group, mainly due to the balance between a higher rate of TVR (HRadj 9.71, p = 0.02) and a lower rate of stroke (HRadj 0.22, p = 0.09) with the PCI group than in the CABG group. Conclusions: The decision making of treatment strategy was made based on clinical and angiographic factors. The selected patients who received PCI showed similar MACE and trend of a lower rate of composite hard endpoints despite multivariate adjustment.
Low-Noise Road Surfaces: European State of the Art

This article summarizes the current knowledge and practice in Europe about tire/road noise and the use of road surfaces to control road traffic noise with emphasis on asphalt pavements. The performances of porous asphalt and thin layers are discussed. Further improvements are sought by testing 2-layer porous asphalt and poro-elastic pavements.
Antecedents of the Concept of Travel Intention During the Pandemic: A Case Study from Turkey

The purpose of this study is to reveal the effect of Covid-19 fear on travel intention and to test the mediating effect of reliance on vaccine in the relationship between fear of Covid-19 and travel intention. In this context, a structural model was created to examine these three variables: the relationship among fear of Covid-19, travel intention and trust in the vaccine. The quantitative study was carried out through a structural model in order to verify the behavior of the three variables together using IBM AMOS 24 package. A case study based on data collected from 467 public employees across Turkey supported empirically the study. At the end of the analysis, it was found that the fear of Covid-19 significantly and negatively affected the travel intention, while the fear of covid-19 significantly and negatively affected the trust in the vaccine, and no significant relationship was found between the trust in the vaccine and the travel intention. In the model in which the mediation effect was tested, it was found that trust in vaccine did not have a mediating effect on the relationship between fear of Covid-19 and travel intention. Considering these results, suggestions were made for the decision makers of travel, tourism and hospitality industry to be able to recover after the pandemic to create plan for policy and strategies.
Serological screening suggests single SARS-CoV-2 spillover events to cattle

Widespread human SARS-CoV-2 infections pose a constant risk for virus transmission to animals. Here, we serologically investigated 1000 cattle samples collected in late 2021 in Germany. Eleven sera tested antibody-positive, indicating that cattle may be occasionally infected by contact to SARS-CoV-2-positive keepers, but there is no indication of further spreading.
Leadership and followership practices in learning organisations:a case study of Abu Dhabi education council

This thesis studies the relationship between practices in learning organisation and social practices at the Abu Dhabi Education Council (ADEC). The research domain was broken down into six research (questions), which affect the development of a learning organisation at ADEC. 1) What is the impact of the roles of leaders on developing learning organisation characteristics with in ADEC? 2) What is the impact of the relationship between leaders and followers on developing learning organisation characteristics with in ADEC? 3) What is the impact of training and professional development on developing learning organisation characteristics with in ADEC? 4) What is the impact of social practices on developing learning organisation characteristics with in ADEC? 5) What is the impact of the teamwork on developing learning organisation characteristics with in ADEC? And 6) What is the impact of organisational factors (vision and mission of ADEC, division of work, information and reward system) on developing learning organisation characteristics with in ADEC? In order to answer the six research questions, interviews and focus groups were conducted with leaders and followers. The sample of study accounted for 10 leaders and 20 followers, four focus groups were conducted (two with leaders and two with followers) where 32 participants took part in the focus groups. The results of the study indicate that leaders do not play a supervisory or coaching role in the departments, which enables followers to work towards achieving the goal of being part of a learning organisation. The study found that leaders and followers have developed a good relationship based on accountability and transferability, and this has helped to transform ADEC into a learning organisation. It also shows that followers have not yet developed sufficient skills through training and workshops and formal education to enable them to learn. The study shows that social practices were the main motivator, encouraging leaders and followers to learn from one another and from expatriates. To summarise briefly, it can be concluded that ADEC has not yet become a learning organisation, and that further work is required to develop the role of its leaders, the relationship between its leaders and followers, and an effective reward system, as well as multiple sources of information.