Miracle-dz/UniFAR-FTUs huggingface dataset:
University of Birmingham Sensory and motor differences in autism spectrum conditions and developmental coordination disorder in children

Recent research has shown that Developmental coordination disorder (DCD) can present with some similar symptomology as Autism Spectrum Conditions (ASC). This paper therefore explored the similarities and differences in coordination and sensory responsivity between DCD and ASC. 77 children took part: 42 (35 male, 7 female) with ASC (ages 7-21: mean age 12.23 years), 26 (19 male, 7 female) with DCD (ages 7-21; mean age 11.07 years) and 9 (2 male, 7 female) with ASC and DCD (ages 8-15; mean age 12.27). All groups completed a battery of validated parent report measures online that included motor coordination (DCDQ), sensory responsivity (SPC-R) and social communication measures (AQ). Results showed no significant differences in coordination, and some significant differences in sensory responsivity between ASC and DCD (increased visual and auditory responsivity and decreased proprioception). Exploratory analysis showed that these differences showed good validity in identifying the diagnosis of ASC and DCD. These results elucidate the underlying causes of motor coordination difficulties in both conditions. Specifically, ASC coordination difficulties appear linked to visual processing impairments, whilst DCD coordination difficulties appear to be linked to spatial processing. This may aid better diagnosis and intervention for these conditions.
University of Birmingham pi0 and eta meson production in proton-proton collisions at s=8 TeV

An invariant differential cross section measurement of inclusive π 0 and η meson production at mid-rapidity in pp collisions at √ s = 8 TeV was carried out by the ALICE experiment at the LHC. The spectra of π 0 and η mesons were measured in transverse momentum ranges of 0 . 3 < p T < 35 GeV/c and 0 . 5 < p T < 35 GeV/c, respectively. Next-to-leading order perturbative QCD calculations using fragmentation functions DSS14 for the π 0 and AESSS for the η overestimate the cross sections of both neutral mesons, although such calculations agree with the measured η/π 0 ratio within uncertainties. The results were also compared with PYTHIA 8.2 predictions for which the Monash 2013 tune yields the best agreement with the measured neutral meson spectra. The measurements conﬁrm a universal behavior of the η/π 0 ratio seen for NA27, PHENIX and ALICE data for pp collisions from √ s = 27 . 5 GeV to √ s = 8 TeV within experimental uncertainties. A relation between the π 0 and η production cross sections for pp collisions at √ s = 8 TeV is given by m T scaling for p T > 3 . 5 GeV/c. However, a deviation from this empirical scaling rule is observed for transverse momenta below p T < 3 . 5 GeV/c in the η/π 0 ratio with a signiﬁcance of 6 . 2 σ .
On M X / G ( M / H )/ 1 retrial system with vacation: service helpline performance measurement

This paper analyzes an unreliable M X / G ( M / H )/ 1 retrial system with vacation. We present closed-form expressions for the important performance indicators of the system, and derive the optimal vacation policies for minimizing the average waiting time of orbiting customers. The performance metrics relevant for helpline services are developed. Numerical experiments are conducted to examine the effect of vacation policy on the queue length and busy period of the system.
Aspergillus fumigatus change Gasdermin-D-dependent pyrolysis of the lung through regulating TRL2-dependent Regulatory T cells differentiation

Aspergillus fumigatus, as opportunistic fungi, lead to infection in the lungs and even systemic infection. The A. fumigatus interacts with the body through a series of complex and dynamic processes. After the fungi have invaded the host, it has a series of adaptive mechanisms which it applies to evade being detected by a host immune system also ways to retaliate against the immune responses. Regulatory T cells (Tregs) in enhancing immune tolerance and immune escape by inhibiting the body's immune response are concerned. It could increase the sensitivity of bacterial infections. When A. fumigatus enters the host, it stimulates Toll-like receptor 2 (TLR2) and triggers the signal transduction pathway. However, how Tregs affects susceptibility to A. fumigatus and TLR2 changes Tregs in A. fumigatus infection is unclear. We examined whether A. fumigatus induces Tregs proliferation in vivo, molecular mechanisms underlying A. fumigatus-stimulated TLR2 activation and the contribution of Tregs activation to susceptibility to A. fumigatus. We observed that Tregs to CD4 + T cells ratio increased in samples from patients infected with Aspergillus fumigatus. After conducting tests in mice, it was revealed that when mice were infected with A. fumigatus, there was an enhancement in the Tregs to CD4 + T cells ratio and Foxp3 expression levels which happen in the lungs also up-regulate. Inhibited Tregs by using CD25 neutralizing antibodies, and we found that the number of fungal burdens in the lung was decreased when these CD25 neutralizing antibodies are used. In our research, A. fumigatus infection can indeed stimulate TLR2 expression to increase, and for the lungs, damages and fungal burden caused by TLR2 −/− mice were reduced. Then it also found that in TLR2 −/ -mice, pyrolysis-related proteins (GSDMD, IL-1α, and IL-1β) changed. It was concluded that for TLR2 knockout animals, the Treg cells quantities are signi�cantly linked to vulnerability to be infected with A. fumigatus. The infection triggered the proliferation and differentiation of CD4 + CD25 + Foxp3 + Tregs through the activation of TLR2 pathway. It is a potential mechanism to evade host defense in A. fumigatus infection of the lung. And this effect can regulate GSDMD-dependent pyrolysis, and may involve TRL2 signals partially.
Condition openness is associated with better mental health in individuals with an intersex/ differences of sex development condition: structural equation modeling of European multicenter data

Background. Openness on one ’ s health condition or (stigmatized) identity generally improves mental health. Intersex or differences of sex development (DSD) conditions have long been kept concealed and high levels of (internalizing) mental health problems are reported. This study examines the effects of condition openness on anxiety and depression and the role of mediating concepts in this population. Methods. Cross-sectional data of individuals of 16 years and older with an intersex/DSD condition was collected in 14 specialized European clinics as part of the dsd-LIFE study. Patient-reported measures were taken on openness and shame (Coping with DSD), self-esteem (Rosenberg Self-Esteem Scale), satisfaction with care (CSQ4), anxiety and depression (HADS). Scores were compared per clinical group and data were analyzed via structural equation modeling (SEM) to calculate prediction and mediation models. Results. Data of 903 individuals were included in this study (Turner syndrome ( n = 284), 46, XY DSD ( n = 233), CAH ( n = 206) and Klinefelter syndrome ( n = 180)). Participants were moderately open on their condition. High levels of both anxiety and depression were observed across the sample. In SEM analysis, the tested models predicted 25% of openness, 31% of anxiety and 48% of depression. More condition openness directly predicted lower anxiety and depression symptoms, as well as indirectly through increased self-esteem, self-satisfaction and satisfaction with social support. Conclusions. Condition openness is associated with lower anxiety and depression in individuals with an intersex/DSD condition. Healthcare may provide the necessary knowledge and skills to employ one ’ s optimal level of self-disclosure in order to improve mental health.
Darkened leaves use different metabolic strategies for senescence and 37 survival 38 39

Running title: Leaf Metabolism in Response to Dark Treatments 1 2 Author for correspondence: 3 Olivier Keech 4 Department of Plant Physiology, Umeå Plant Science Centre, Umeå University, S5 90187 Umeå, Sweden 6 e-mail: olivier.keech@umu.se 7 8 Title: Darkened leaves use different metabolic strategies for senescence and 9 survival 10 11 12 Research area: Biochemistry and metabolism 13 14 Plant Physiology Preview. Published on March 9, 2018, as DOI:10.1104/pp.18. 00062
Reassessment of the number of auxiliary genes essential for expression of high-level methicillin resistance in Staphylococcus aureus

A new transposon library constructed in the background of the highly and homogeneously methicillin-resistant Staphylococcus aureus strain COL yielded 70 independent insertional mutants with reduced levels of antibiotic resistance. Restriction analysis with HindIII, EcoRV, EcoRI, and PstI and then Southern hybridization with probes for the transposon and for the femA-femB gene demonstrated that 41 of the 70 Tn551 mutants carried distinct and novel, as yet undescribed insertion sites, all of which were outside of the mecA gene and were also outside the already-characterized auxiliary genes femA, femB, femC, and femD. All previously described Tn551 mutations of this type were in genes located either on SmaI fragment A or SmaI fragment I. In contrast, inserts of the new library were located in 7 of the 16 SmaI chromosomal fragments, fragments A, B, C, D, E, F, and I. In all of the mutants, expression of methicillin resistance became heterogeneous, and the MIC for the majority of cells was reduced (1.5 to 200 micrograms ml-1) from the homogeneous methicillin MIC (1,600 micrograms ml-1) of the parental cells. Although identification of the exact number of genes inactivated through the new set of transposon inserts will require cloning and sequencing, a rough estimate of this number from mapping data suggests a minimum of at least 10 to 12 new genetic determinants, all of which are needed together with femA, femB, femC, and femD for the optimal expression of methicillin resistance.
Activated Carbon Derived from Egyptian Banana Peels for Removal of Cadmium from Water

This study was conducted to investigate the removal of cadmium (II) from aqueous solution by using low cost, natural and eco-friendly biosorbent of Banana peels Activated Carbon (BPAC) through batch experiments. The Activated Carbon was characterized by FTIR, SEM, TEM with EDX. Various adsorption parameters such as effect of pH, amount of the biomass, initial concentration of Cadmium ion and contact time on the adsorption capacity of the biosorbent were studied. Biosorption experiments were carried out at the temperature of 25ºC. The percent removal of Cadmium ions was 98.35% from synthetic wastewater. These results were observed at the optimum dose of 0.8 g at pH 4.0. The removal of Cadmium ions from wastewater is mainly influenced by pH of the synthetic wastewater and the amount of biosorbent dose. The equilibrium adsorption data were fitted to Langmuir adsorption isotherm model and the model parameters were evaluated. The kinetic study showed that the pseudo-second order kinetic model better described the biosorption process. These results demonstrated that the Banana peels could be used as a natural biosorbent for removal of Cadmium from aqueous solution.
An Enhanced Outlier Detection in Wireless Sensor Network

— Nowadays, Wireless Sensor Networks (WSNs) have become a way of information gathering and monitoring. These particular kinds of ad hoc networks find applications in various fields such as healthcare, army and environment, etc. However, WSNs are subjected to a number of faults, either due to the worst communication links, the hostile environment in which they are deployed or due to energy constraints. Thereby, to ensure the Quality of Service (QoS) in such networks, it is important that WSNs become capable of detecting and recovering erroneous data. In this way, many outlier detection techniques have been proposed. These techniques are based on information theory, statistics and other techniques. The Nearest Neighbour Search is one of these techniques. It uses the Euclidean or Mahalanobis distance for detecting outliers in a given sensor networks. In this paper, we proposed a distributed adaptive approach for the detection of outliers. The proposed approach is based on Euclidean or Mahalanobis distance, depending on the size of the data collected. Extensive experiments have been conducted and the results confirmed the effectiveness of the proposal
Austin Plastic Surgery: Open Access Pleithropic Effects of Erythropoietin and Its Potential use in Plastic Surgery

The different effects of EPO within the various organ systems (erythropoiesis, versus anti-inflammatory and pro-regenerative effects) can most likely be explained through a different affinity to the individual receptor types and receptor subtypes [20]. The tissue protective properties are mediated by an EPO hetero receptor, whose affinity to EPO is less than that of the EPOR2 receptor, which mediates the erythropoietic effect of EPO. The EPO hetero receptor is usually not found in healthy tissues, but in post-traumatic settings it has been described several times [19]. This could explain, among other things, why EPO works only after trauma pro-regenerative and pro-proliferative [6]. Since the detection of the EPO hetero receptor has not been successful so far (see below) this approach is still being discussed in a controversial way.
Elevated slabs made of hybrid reinforced concrete: Proposal of a new design approach in flexure

When designing fiber‐reinforced concrete (FRC) structures, one of the basic design issues is represented by the choice of a proper combination of fibers and conventional reinforcement that allows to obtain the best structural performance with the minimum amount of materials. The combination of rebars and fibers in the concrete matrix is generally known as Hybrid Reinforced Concrete (HRC). HRC represents a feasible solution in many structures; among these, slabs are gaining an increasing interest among practitioners. In fact, slabs are the most widespread structural elements in common practice as they are typically used to construct slabs on ground (industrial floors or foundations), slabs on piles (foundations) or elevated slabs. This paper focuses on the flexural design of FRC elevated slabs by using the most recent design provisions reported in the fib Model Code 2010. A simplified design procedure based on a consolidated design practice is proposed. Emphasis is given to the use of HRC to minimize the total reinforcement (fibers + rebars) in order to get practical and economic advantages during construction (ie, construction time and costs reduction). In more detail, a procedure for proportioning the hybrid reinforcement and then verifying the structural safety will be presented and discussed. Numerical nonlinear finite element analyses will be carried out to assess the effectiveness of the proposed design method.
Academic Performance and the Level of Use of Metacognitive Self-Regulatory Learning Strategies by Accounting Students

: Objective. Analyze the relationship between academic performance and the level of use of metacognitive self-regulated learning strategies by accounting students. Method. The study approach was quantitative, using exploratory factor analysis, Structural Equation Modelling and Multiple Linear Regression to answer the research question. The sample of the study initially comprised 107 students of Accounting in the modality of face-to-face teaching of three public Universities that fully answered the research instrument. Results. The data were first processed through an exploratory factorial analysis, which allows the indication of the necessary amount of factors, to define the constructs used in the structural equations. In addition, a multiple regression was performed to verify the strategies that influence in the performance. Conclusions. Indicate that students who self-evaluate and seek help from teachers, colleagues, or specialists are the ones who achieve the best academic performance. Thus, it can be concluded that academic performance may be related to the level of use of the metacognitive strategies In this context, we have the following research problem that guides the present study: What is the relationship between academic performance and the level of use of metacognitive learning strategies self-regulated by accounting students? To answer the problem question, the study seeks to analyze the relationship between academic performance and the metacognitive self-regulated learning strategies by accounting students. The importance and the theoretical contribution of this research how the academic performance be explained by the level of utilization of the metacognitive strategies of self-regulated learning of accounting students. This contribution is essential in the light of the recognition that students, future professionals in accounting, need to develop critical thinking skills, continuous and the ability to provide quality for a Accounting
Alterations of p53 and PIK3CA/AKT/mTOR Pathways in Angiosarcomas: A Pattern Distinct from Other Sarcomas with Complex Genomics

Background— The p53 and the PIK3CA/AKT/mTOR pathways are frequently altered in sarcoma with complex genomics such as leiomyosarcoma (LMS) or undifferentiated pleomorphic sarcoma (UPS). The scale of genetic abnormalities in these pathways remains unknown in angiosarcoma. Methods— We investigated the status of critical genes involved in the p53 and the PIK3CA/ AKT/mTOR pathways in a series of 62 AS. Results— The mutation and deletion rates of TP53 were 4% and 0, respectively. p53 overexpression was detected by immunohistochemistry in 49% of cases and was associated with inferior disease-free survival. Although p14 inactivation or HDM2 overexpression are frequent in LMS and UPS and could substitute for TP53 mutation or deletion, such alterations were rare in angiosarcomas. pS6K and/or p-4eBP1 overexpression was observed in 42% of cases suggesting frequent activation of the PIK3CA/AKT/mTOR pathway in angiosarcomas. Activation was not related to intragenic deletion of PTEN, an aberration that is frequent in LMS and UPS, but absent in angiosarcomas. Conclusion— Angiosarcomas constitute a distinct subgroup among sarcomas with complex genomics. Although TP53 mutation and PTEN deletion are frequent in LMS and UPS, these aberrations are rarely involved in the pathogenesis of AS.
Temporal association coding in the medial prefrontal cortex: Difference in the role among distinct neuron types

The ability to associate two stimuli that are separated by a temporal gap requires at least two types of information: what has been presented (trace holding) and what will follow (temporal expectation). It has been shown that neurons in the medial prefrontal cortex (mPFC) can be selective for trace holding, temporal expectation or both. It remains unknown, however, what the distinct role of different neuron types is in representing trace holding and temporal expectation. Thus, the present study investigates the role of three distinct neuron types found in mPFC by applying a series of analyses. The narrow-waveform and fast-spiking neurons were more selective for trace holding than temporal expectation. The wide-waveform regular-firing neurons were equally selective for both types of information and the wide-waveform bursting neurons were less selective than the other neuron types. Therefore, I found that three neuron types have distinct contributions to the encoding of temporal association.
Antibacterial activity of two Streptomyces species isolated from Egyptian and Libyan soils

Sixty five actinomycetes isolates were collected from different Egyptian and Libyan soils. Forty eight isolates from the collected actinomycetes were found to be active against some tested pathogenic bacteria. Two different actinomycetes isolates (one from each country) which showed considerable higher antibacterial activity were identified as Streptomyces pluricolorescens and Streptomyces alni. They were also selected for optimizing the best conditions for their antibacterial activity production. The optimum incubation period, temperature and initial pH of medium for the maximum antibacterial yield were 5 days, 30 o C and pH 7, respectively, for both of Streptomyces species. The maximum antibacterial production was observed on Dox and starch ammonium sulfate media for S. pluricolorescens , while starch nitrate was the most suitable media for S. alni antibacterial productivity.
Activated Murine Eosinophils Carbonic Anhydrase IV Is Expressed on IL-5

Eosinophilia and its cellular activation are hallmark features of asthma, as well as other allergic/Th2 disorders, yet there are few, if any, reliable surface markers of eosinophil activation. We have used a FACS-based genome-wide screening system to identify transcriptional alterations in murine lung eosinophils recruited and activated by pulmonary allergen exposure. Using a relatively strin-gent screen with false-positive correction, we identiﬁed 82 candidate genes that could serve as eosinophil activation markers and/or pathogenic effector markers in asthma. Carbonic anhydrase IV ( Car4 ) was a top dysregulated gene with 36-fold induction in allergen-elicited pulmonary eosinophils, which was validated by quantitative PCR, immunohistochemistry, and ﬂow cytometry. Eosinophil CAR4 expression was kinetically regulated by IL-5, but not IL-13. IL-5 was both necessary and sufﬁcient for induction of eosinophil CAR4. Although CAR4-deﬁcient mice did not have a defect in eosinophil recruitment to the lung, nor a change in eosinophil pH-buffering capacity, allergen-challenged chimeric mice that contained Car4 2 / 2 hematopoietic cells aberrantly expressed a series of genes enriched in biological processes involved in epithelial differentiation, keratinization, and anion exchange. In conclusion, we have determined that eosinophils express CAR4 following IL-5 or allergen exposure, and that CAR4 is involved in regulating the lung transcriptome associated with allergic airway inﬂammation; therefore, CAR4 has potential value for diagnosing and monitoring eosinophilic responses. The Journal of Immunology , 2014, 192: 000–000.
Registered Replication Report: Strack, Martin, & Stepper (1988)

Registered Abstract According to the facial feedback hypothesis , people’s affective responses can be influenced by their own facial expression (e.g., smiling, pouting), even when their expression did not result from their emotional experiences. For example, Strack, Martin, and Stepper (1988) instructed participants to rate the funniness of cartoons using a pen that they held in their mouth. In line with the facial feedback hypothesis, when participants held the pen with their teeth (inducing a “smile”), they rated the cartoons as funnier than when they held the pen with their lips (inducing a “pout”). This seminal study of the facial feedback hypothesis has not been replicated directly. This Registered Replication Report describes the results of 17 independent direct replications of Study 1 from Strack et al. (1988), all of which followed the same vetted protocol. A meta-analysis of these studies examined the difference in funniness ratings between the “smile” and “pout” conditions. The original Strack et al. (1988) study reported a rating difference of 0.82 units on a 10-point Likert scale. Our meta-analysis revealed a rating difference of 0.03 units with a 95% confidence interval ranging from − 0.11 to 0.16.