Miracle-dz/UniFAR-FTUs huggingface dataset:
The Banana (Musa balbisiana Colla) Peels Flour Modulates HTR2B Receptor Expression in the Liver Diabetic Rats

Uncontrolled diabetes mellitus (DM) has been linked to depression and lipid metabolism impairment. Serotonin (5-HT) has been known to improve lipid metabolism and affect mood. The 5-Hydroxytryptophan (5-HTP) in banana peel flour (BPF) is a precursor to synthesize 5-HT in the body, which is linked to initiating liver regeneration via HTR2B receptors. The impact of 5-HTP in the diet on HTR2B receptor expression has yet to be thoroughly investigated. We aimed to elucidate the correlation between serum lipid profile and immobility time in Tail Suspension Test (TST) as depressive-like behavior and compare the expression of HTR2B receptor in healthy and diabetic rats. Male Wistar (Rattus norvegicus) rats were assigned to the control and treatment groups in a DM model with streptozotocin (60 mg/kg) injected intraperitoneally, then either fed standard diet or BPF 10% supplemented standard diet for 21 days. Immunohistochemical staining was used to examine the expression of 5-HT, HTR2B receptors. We determined that diabetic rats fed the standard diet supplemented 10% BPF group showed significantly lower concentrations of total cholesterol and triglycerides compared to diabetic rats fed a standard diet and it was positively correlated between total cholesterol and LDL with the duration of immobility time in TST. The average immunoreactivity score in diabetic rats fed 10% BPF was the highest among the other groups, indicating that the available BPF dose is sufficient for HTR2B activation, which will support the liver cell regeneration process, and should be investigated further.
Environmental Sustainability and Supply Resilience of Cobalt

Cobalt (Co) is an essential metal for the development of energy-transition technologies, decarbonising transportation, achieving several sustainable development goals, and facilitating a future net zero transition. However, the supply of Co is prone to severe fluctuation, disruption, and price instabilities. This review aims to identify the future evolution of Co supply through technologically resilient and environmentally sustainable pathways. The work shows that advances in both primary and secondary sources, Co mining methods and recycling systems are yet to be fully optimised. Moreover, responsible sourcing from both large mines and small artisanal mines will be necessary for a resilient Co supply. Regulatory approaches may increase transparency, support local mining communities, and improve secondary Co recovery. Novel Co supply options, such as deep-sea mining and bio-mining of tailings, are associated with major techno-economic and environmental issues. However, a circular economy, keeping Co in the economic loop for as long as possible, is yet to be optimised at both regional and global scales. To achieve environmental sustainability of Co, economic incentives, regulatory push, and improved public perception are required to drive product innovation and design for circularity. Although the complexity of Co recycling, due to lack of standardisation of design and chemistry in batteries, is an impediment, a sustainable net zero transition using Co will only be possible if a reliable primary supply and a circular secondary supply are established.
Leader–follower psychological capital congruence and work outcomes: the mediating role of organizational embeddedness

PurposeBased on the micro role transition theory (MRTT), the present study aims to explore how leader–follower congruence in psychological capital (PsyCap) affects followers' task performance and voice behavior, in which we uncover the mediating role of organizational embeddedness.Design/methodology/approachA survey was conducted in South China through a three-stage procedure, and finally, a dyad-structured sample of 62 leaders and 218 employees was matched. The polynomial regression method, response surface analysis and structural equation modeling were employed to test the effects of leader–follower PsyCap congruence.Findings(1) Followers' organizational embeddedness will be higher when leaders' and followers' PsyCap are more aligned; (2) followers' organizational embeddedness will be higher when leaders' and followers' PsyCap are aligned at a high level rather than when they are aligned at a low level; (3) followers' organizational embeddedness will be higher when followers' PsyCap is higher than leaders', compared to when followers' PsyCap is lower than leaders'; (4) organizational embeddedness mediates the relationship between leader–follower PsyCap congruence and followers' (a) task performance and (b) voice behavior.Originality/valueThis study emphasizes leaders' pivotal role in a process where followers' PsyCap affects task performance and voice behavior, and further extends MRTT through introducing organizational embeddedness as a mediator in such a mechanism.
Cardiometabolic Risk Factors and Endogenous Sex Hormones in Postmenopausal Women: A Cross-Sectional Study

Abstract Context It is uncertain which cardiovascular risk factors are associated with sex hormone levels in postmenopausal women. Objective This work aimed to investigate the association between cardiometabolic risk factors and sex hormones in a cross-sectional, observational population study. Methods In this Swedish population study, participants were physically examined from 2002 to 2004, and endogenous sex hormones were analyzed by liquid chromatography–tandem mass spectrometry. Women aged 55 years or older with estradiol levels below 20 pg/mL and not using any hormonal therapy were eligible for inclusion in the study (N = 146). Variable selection and bootstrap stability analyses were performed and linear regression models presented, with each of the 8 hormones as outcome variables. Results Body mass index (BMI) was positively associated with estradiol (β = 0.054, P < .001), but negatively associated with 17-α-hydroxyprogesterone (β = –0.023, P = .028). Waist-to-hip ratio (WHR) was negatively associated with dihydrotestosterone (β = –2.195, P = .002) and testosterone (β = –1.541, P = .004). The homeostatic model assessment of insulin resistance was positively associated with androstenedione (β = 0.071, P = .032), estradiol (β = 0.091, P = .009), estrone (β = 0.075, P = 0.009), and 17-α-hydroxyprogesterone (β = 0.157, P = .001). Age was positively associated with testosterone (β = 0.017, P = .042). C-reactive protein showed an inverse association with progesterone (β = –0.028, P = .037). Lower low-density lipoprotein cholesterol was associated with higher estradiol levels (β = –0.093, P = .049), whereas lower triglycerides were associated with higher concentrations of dihydrotestosterone (β = –0.208, P = .016). Conclusion In postmenopausal women, WHR was strongly inversely associated with androgens, while BMI was positively associated with estrogens.
High-Throughput Screening of a Marine Compound Library Identifies Anti-Cryptosporidium Activity of Leiodolide A

Cryptosporidium sp. are apicomplexan parasites that cause significant morbidity and possible mortality in humans and valuable livestock. There are no drugs on the market that are effective in the population most severely affected by this parasite. This study is the first high-throughput screen for potent anti-Cryptosporidium natural products sourced from a unique marine compound library. The Harbor Branch Oceanographic Institute at Florida Atlantic University has a collection of diverse marine organisms some of which have been subjected to medium pressure liquid chromatography to create an enriched fraction library. Numerous active compounds have been discovered from this library, but it has not been tested against Cryptosporidium parvum. A high-throughput in vitro growth inhibition assay was used to test 3764 fractions in the library, leading to the identification of 23 fractions that potently inhibited the growth of Cryptosporidium parvum. Bioassay guided fractionation of active fractions from a deep-sea sponge, Leiodermatium sp. , resulted in the purification of leiodolide A, the major active compound in the organism. Leiodolide A displayed specific anti-Cryptosporidium activity at a half maximal effective concentration of 103.5 nM with selectivity indexes (SI) of 45.1, 11.9, 19.6 and 14.3 for human ileocecal colorectal adenocarcinoma cells (HCT-8), human hepatocellular carcinoma cells (Hep G2), human neuroblastoma cells (SH-SY5Y) and green monkey kidney cells (Vero), respectively. The unique structure of leiodolide A provides a valuable drug scaffold on which to develop new anti-Cryptosporidium compounds and supports the importance of screening natural product libraries for new chemical scaffolds.
To dee or not to dee: costs and benefits of altering the triangularity of a steady-state DEMO-like reactor

Shaping a tokamak plasma to have a negative triangularity may allow operation in an edge-localized mode-free L-mode regime and with a larger strike-point radius, ameliorating divertor power-handling requirements. However, the shaping has a potential drawback in the form of a lower no-wall ideal beta limit, found using the MHD codes chease and dcon. Using the new fusion systems code faroes, we construct a steady-state DEMO2 reactor model. This model is essentially zero-dimensional and neglects variations in physical mechanisms like turbulence, confinement, and radiative power limits, which could have a substantial impact on the conclusions deduced herein. Keeping its shape otherwise constant, we alter the triangularity and compute the effects on the levelized cost of energy (LCOE). If the tokamak is limited to a fixed B field, then unless other means to increase performance (such as reduced turbulence, improved current drive efficiency or higher density operation) can be leveraged, a negative-triangularity reactor is strongly disfavored in the model due to lower β N limits at negative triangularity, which leads to tripling of the LCOE. However, if the reactor is constrained by divertor heat fluxes and not by magnet engineering, then a negative-triangularity reactor with higher B 0 could be favorable: we find a class of solutions at negative triangularity with lower peak heat flux and lower LCOE than those of the equivalent positive triangularity reactors.
Electrical Conductivity of KCl‐H2O Fluids in the Crust and Lithospheric Mantle

Evidence from diamond inclusions suggests that KCl‐bearing fluids may be abundant in the subcratonic mantle and these fluids may also cause local anomalies of high electrical conductivity. We therefore measured the electrical conductivity of aqueous fluids containing 6.96, 0.74 and 0.075 wt% KCl using a hydrothermal diamond anvil cell to 2.5 GPa and 675°C, and with a piston‐cylinder apparatus to 5 GPa and 900°C. We found that below 550°C, increasing pressure generally decreases solution conductivity, while at higher temperatures the effect is opposite. However, at high pressures, the conductivity of KCl in H2O is smaller than for NaCl, possibly due to a hydration shell collapse. The experimental data are described by two numerical models. The first model (R2 = 0.999), is preferable for crustal conditions: log σ = −2.03 + 25.0 × T−1 + 0.923 × log c + 0.990 × log ρ + log Λ0, where σ is the conductivity in S/m, T is temperature in K, c is KCl concentration in wt%, ρ is the density of pure water (in g/cm3) at given pressure and temperature. Λ0 is the limiting molar conductivity of KCl (in S·cm2·mol−1): Λ0 = 1,377 – 1,082 × ρ + 6,883 × 102 × T−1 – 2,471 × 105 × T−2. The second model (R2 = 0.986), is applicable to the lithospheric mantle: log σ = −1.52 – 357 × T−1 + 0.865 × log c + 1.72 × log ρ + log Λ0, with the same equation for Λ0. The latter model shows that already traces of KCl‐bearing aqueous fluid may account for high conductivity anomalies in the subcratonic mantle.
Acetylation of Bacterial Cellulose from a Mixture of Palm Flour Liquid Waste and Coconut Water: The Effect of Acetylation Time on Yield and Identification of Cellulose Acetate

Cellulose acetate is a promising thermoplastic polymer to be developed since it has some characteristics, among others are easy to be formed, non-toxic, high stability, and its raw materials are renewable. The most used source of cellulose acetate raw material is bacterial cellulose because bacterial cellulose has the higher purity and the process cost is lower rather than plant cellulose. Nowadays, the production of bacterial cellulose is highly developed using coconut water media. Nevertheless, coconut water costs expensive and the supply is rare. Materials that are being potential to be developed as raw materials of bacterial cellulose through fermentation process is palm flour liquid wasted since it contains high amounts of carbon and nitrogen. This study began with the synthesis of bacterial cellulose from palm flour oil liquid waste and coconut water using Acetobacter xylinum bacteria and then cellulose acetate is synthesized through an acetylation reaction. This study aims to determine the optimum acetylation time on its performance as a reinforcement filler to be applied as a packaging material. Based on the results of Scanning Electron Microscopy and Fourier Transform Infra-Red analysis on predetermined variables, it resulted particles in the form of bacterial cellulose and cellulose acetate with the highest yield of cellulose acetate at 3 hours of acetylation was 94.74%.
POPULATION GENETIC DIVERSITY OF CAMELLIA DILINHENSIS ON THE DI LINH PLATEAU OF VIETNAM REVEALED BY ISSR AND SCOT MARKERS

Genetic diversity of naturally distributed Camellia dilinhensis populations on the Di Linh plateau of Vietnam was assessed by the inter-simple sequence repeat (ISSR) and start codon targeted (SCoT) techniques separately and then by combining data from both techniques for satisfactory results. The genetic diversity parameters and genetic distances among individuals found with the ISSR technique (HeI = 0.1420, II = 0.2092, PPBI = 35.22%, GSCsI = 0.765–0.988, and AGSCI = 0.915) are lower than those found with the SCoT technique (HeS = 0.2100, IS = 0.381, PPBS = 52.27%, GSCsS = 0.644–0.985, and AGSCS = 0.866). Based on the combined data from both techniques, the level of genetic diversity of the investigated population is PPB = 43.77%, He = 0.1720, I = 0.2582, and the genetic similarities among individuals are GSCs = 0.764–0.973 with an average of AGSC = 0.894. The SCoT technique differentiated between individuals better and reflected a higher level of genetic diversity in the population than the ISSR technique, but the ISSR technique revealed more loci in Camellia dilinhensis plants than did the SCoT technique.
Influence of Covid-19 Pandemic Disease on Educational Scheme as Express by Undergraduates

The Covid-19 pandemic disease has modified the education system in Nigeria to distance learning using online platforms to stop and reduce the chain of distribution of coronavirus which highly contagious disease among students. This study objectives are to investigate whether Covid-19 pandemic result to; (1) change in university academic calendar, (2) difficulty in coping with online class, (3) inability to concentrate with online education tools. The population of the study comprised all undergraduates in the Faculty of Education, University of Ilorin, Nigeria. The study adopted a descriptive research design of survey type which involved the use of three-stages sampling techniques to choose two hundred and fifty-seven undergraduates from the five selected departments out of nine departments in the study area. The researcher developed a questionnaire validated by three experts in the related field was used as an instrument for the study. The findings of the study indicated that the Covid-19 pandemic disease has influence on changes in University academic calendar, has influence on the difficulty in coping with online class and also, has influence on inability to concentrate with online educational tools among Undergraduates. The researcher recommends among others that the lecturers should use appropriate techniques and teaching aids that will make online lessons interesting for learners
Bronchoscopic Intra-Pleural Instillation of Fibrin Glue and Autologous Blood to Manage Persistent Air Leaks after Lung Resection

Background: Persistent air leak is a common complication after lung resection causing prolonged length of stay and increased healthcare costs. Surgical intervention can be an option, but other more conservative approaches should be considered first. Here, we describe the use of flexible bronchoscopy to apply fibrin glue and autologous blood sequentially to the damaged lung. We named the technique “flexible thoracoscopy”. Methods: Medical records from patients with persistent air leaks after lung resection were collected retrospectively. Depending on the type of aerostasis that was performed, two groups were created: flexible thoracoscopy and surgery (thoracotomy). Flexible thoracoscopy was introduced at our institution in 2013. We entered the pleural space with a bronchoscope following the same surgical pathway that was used for tube thoracostomy. Perioperative characteristics and outcomes were analyzed using R software (ver. 3.4.4). Results: From 1997 to 2021, a total of 23 patients required an intervention for persistent air leaks. Aerostasis was performed via flexible thoracoscopy in seventeen patients (69%) and via thoracotomy in six patients (31%). The median age was 70 years (22–82). Twenty patients were males (87%). There was no difference in age, sex distribution, BMI, comorbidities and FEV1%. An ASA score of 3 was more represented in the flexible thoracoscopy group; however, no evidence of a difference was found when compared to the thoracotomy group (p = 0.124). Length of in-hospital stay and chest tube duration was also similar between groups (p = 1 and p = 0.68, respectively). Conclusions: Aerostasis achieved either by flexible thoracoscopy or by thoracotomy showed similar results. We believe that flexible thoracoscopy could be a valid alternative to facilitate minimally invasive treatments for persistent air leaks. Further studies are needed to confirm these results.
The Impact of Probiotic Bacillus subtilis on Injurious Behavior in Laying Hens

Simple Summary Injurious behavior prevention is a critical issue in the poultry industry due to increasing social stress, leading to negative effects on bird production and survivability, consequently enhancing gut microbiota dysbiosis and neuroinflammation via the microbiota–gut–brain axis. Probiotics have been used as potential therapeutic psychobiotics to treat or improve neuropsychiatric disorders or symptoms by boosting cognitive and behavioral processes and reducing stress reactions in humans and various experimental animals. The current data will first report that probiotic Bacillus subtilis reduces stress-induced injurious behavior in laying hens via regulating microbiota–gut–brain function with the potential to be an alternative to beak trimming during poultry egg production. Abstract Intestinal microbiota functions such as an endocrine organ to regulate host physiological homeostasis and behavioral exhibition in stress responses via regulating the gut–brain axis in humans and other mammals. In humans, stress-induced dysbiosis of the gut microbiota leads to intestinal permeability, subsequently affecting the clinical course of neuropsychiatric disorders, increasing the frequency of aggression and related violent behaviors. Probiotics, as direct-fed microorganism, have been used as dietary supplements or functional foods to target gut microbiota (microbiome) for the prevention or therapeutic treatment of mental diseases including social stress-induced psychiatric disorders such as depression, anxiety, impulsivity, and schizophrenia. Similar function of the probiotics may present in laying hens due to the intestinal microbiota having a similar function between avian and mammals. In laying hens, some management practices such as hens reared in conventional cages or at a high stocking density may cause stress, leading to injurious behaviors such as aggressive pecking, severe feather pecking, and cannibalism, which is a critical issue facing the poultry industry due to negative effects on hen health and welfare with devastating economic consequences. We discuss the current development of using probiotic Bacillus subtilis to prevent or reduce injurious behavior in laying hens.
Observation of reactive shear layer modulation associated with high-frequency transverse thermoacoustic oscillations in a gas turbine reheat combustor experiment

This paper presents the investigation of high-frequency thermoacoustic oscillations and associated flame dynamics in an experimental gas turbine reheat combustor at atmospheric pressure. Examination of dynamic pressure measurements reveals bursts of high-frequency periodic oscillations which appear randomly amidst stochastic fluctuations in the reheat combustor. Analysis of the flame dynamics during these bursts of periodic behaviour reveals that increased heat release in the reactive shear layers of the reheat flame is associated with greater thermoacoustic driving potential. This redistribution of heat release is likely due to the stochastic nature of auto-ignition kernel formation. To determine the underlying flame-acoustic coupling mechanism behind the driving potential, phase-resolved flame dynamics over the acoustic cycle are investigated which reveal the presence of an oscillatory heat release pattern associated with the first transverse eigenmode. An in-phase interaction between the acoustic field and these heat release oscillations in the shear layer regions indicates that this phenomenon likely constitutes a thermoacoustic driving mechanism. This is an important step towards the development of models for high-frequency thermoacoustic driving mechanisms relevant to reheat combustion systems, which will allow accurate prediction and mitigation of thermoacoustic instabilities in future designs.
Openness to experience is stable following adversity: A case-control longitudinal investigation

Although many people retrospectively report feeling more open-minded after experiencing highly stressful events, relevant longitudinal studies are scarce and have yielded contradictory findings. The present study used a 12-month longitudinal case-control design to test whether growth in openness (assessed every 4 months using multiple methods) occurs following major stressors, and whether changes relate to clinical symptoms of depression and/or posttraumatic stress. To do so, we compared participants (a) with a recent major stressor and with low symptoms (n = 66), (b) without a recent major stressor and with low symptoms (n = 76), and (c) with a recent major stressor and with significant symptoms (n = 76). Overall, growth curve models showed that group membership was not associated with changes in openness over 12 months for most outcomes. Other variables (e.g., education) predicted changes in openness. This study provides robust evidence that openness to experience is mostly stable following major stressors.