Miracle-dz/UniFAR-FTUs huggingface dataset:
Co-Encapsulation of Paclitaxel and JQ1 in Zein Nanoparticles as Potential Innovative Nanomedicine

The manuscript describes the development of zein nanoparticles containing paclitaxel (PTX) and the bromo-and extra-terminal domain inhibitor (S)-tertbutyl2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno(3,2-f)(1,2,4)triazolo(4,3-a)(1,4)diazepin-6-yl)acetate (JQ1) together with their cytotoxicity on triple-negative breast cancer cells. The rationale of this association is that of exploiting different types of cancer cells as targets in order to obtain increased pharmacological activity with respect to that exerted by the single agents. Zein, a protein found in the endosperm of corn, was used as a biomaterial to obtain multidrug carriers characterized by mean sizes of ˂200 nm, a low polydispersity index (0.1–0.2) and a negative surface charge. An entrapment efficiency of ~35% of both the drugs was obtained when 0.3 mg/mL of the active compounds were used during the nanoprecipitation procedure. No adverse phenomena such as sedimentation, macro-aggregation or flocculation occurred when the nanosystems were heated to 37 °C. The multidrug nanoformulation demonstrated significant in vitro cytototoxic activity against MDA-MB-157 and MDA-MB-231 cancer cells by MTT-test and adhesion assay which was stronger than that of the compounds encapsulated as single agents. The results evidence the potential application of zein nanoparticles containing PTX and JQ1 as a novel nanomedicine.
Formula development of sizing for basalt fiber. Part I: Role of film former

Abstract Sizing is a multi-element liquid system consisting of film former, coupling agent and other functional additives. In this article, Taguchi method with orthogonal array design was used to get an optimal formula of sizing for basalt fiber, and the role of film former in sizing was studied. The results showed film former promoted the sizing to spread on fiber surface, which increased the interaction area between the fiber and sizing. With the assistance of film former in sizing, a uniform layer was formed on fiber surface, which repaired the surface defect on basalt fiber with reduced stress concentration. The sizing with an appropriate concentration of film former had the capability to increase the tensile strength of a single filament with the best effect of forming a film on fiber surface.
Establishment of a reverse transcription real-time quantitative PCR method for Getah virus detection and its application for epidemiological investigation in Shandong, China

Getah virus (GETV) is a mosquito-borne, single-stranded, positive-sense RNA virus belonging to the genus Alphavirus of the family Togaviridae. Natural infections of GETV have been identified in a variety of vertebrate species, with pathogenicity mainly in swine, horses, bovines, and foxes. The increasing spectrum of infection and the characteristic causing abortions in pregnant animals pose a serious threat to public health and the livestock economy. Therefore, there is an urgent need to establish a method that can be used for epidemiological investigation in multiple animals. In this study, a real-time reverse transcription fluorescent quantitative PCR (RT-qPCR) method combined with plaque assay was established for GETV with specific primers designed for the highly conserved region of GETV Nsp1 gene. The results showed that after optimizing the condition of RT-qPCR reaction, the minimum detection limit of the assay established in this study was 7.73 PFU/mL, and there was a good linear relationship between viral load and Cq value with a correlation coefficient (R2) of 0.998. Moreover, the method has good specificity, sensitivity, and repeatability. The established RT-qPCR is 100-fold more sensitive than the conventional RT-PCR. The best cutoff value for the method was determined to be 37.59 by receiver operating characteristic (ROC) curve analysis. The area under the curve (AUC) was 0.956. Meanwhile, we collected 2,847 serum specimens from swine, horses, bovines, sheep, and 17,080 mosquito specimens in Shandong Province in 2022. The positive detection rates by RT-qPCR were 1%, 1%, 0.2%, 0%, and 3%, respectively. In conclusion, the method was used for epidemiological investigation, which has extensive application prospects.
Statistical Factors Affecting the Intensity of X-Rays Diffracted

The Laplacian probability equation can be used to predict the reproducibility of the intensities of x‐rays diffracted by crystalline powders. If absorption is neglected, and N is the number of particles irradiated, p the proportion of particles which are oriented so as to diffract, and q=1 − p, the relative mean deviation to be expected in repeated intensity measurements is given by Um=0.798 (q/Np)½. When absorption and the actual distribution of particle sizes are taken into account, the expression becomes Um=0.798(qμve/pA)12, where μ is the linear absorption coefficient of the material, ve the effective volume per particle, and A the cross‐sectional area of the incident beam.The theory is confirmed by measurements on four size fractions of quartz powder using a Norelco Geiger‐counter x‐ray spectrometer. For typical experimental conditions and powders of medium absorbing power for x‐rays, it is demonstrated that good reproducibility can be expected only if the effective particle dimension is less than ap.
Wavelets and Operators

Introduction 1. Fourier series and integrals, filtering and sampling 2. Multiresolution approximation of L2(Rn) 3. Orthonormal wavelet bases 4. Non-orthogonal wavelets 5. Wavelets, the Hardy space H1, and its dual BMO 6. Wavelets and spaces of functions and distributions References.
Biomolecular Mechanisms of Cardiorenal Protection with Sodium-Glucose Co-Transporter 2 Inhibitors

Diabetes mellitus (DM) is a metabolic disorder characterized by chronic hyperglycemia and associated with an increased risk of morbidity and mortality, primarily from cardiovascular and renal diseases. Sodium-glucose cotransporter 2 inhibitors (SGLT2-Is) are novel drugs for the treatment of type 2 DM and heart failure (HF). SGLT2-Is mediate protective effects on both the renal and cardiovascular systems. This review addresses the current knowledge on the biomolecular mechanisms of the cardiorenal protective effects of SGLT2-Is, which appear to act mainly through non-glucose-mediated pathways. Cardiorenal protection mechanisms lead to reduced chronic renal disease progression and improved myocardial and coronary endothelial function. Concomitantly, it is possible to observe reflected changes in biomarkers linked with diabetic kidney disease and HF.
Differences in health literacy domains among migrants and their descendants in Germany

Background Health literacy (HL) is considered to be an important precondition for health. HL research often identifies migrants as vulnerable for low HL. However, in-depth data on HL among migrants especially in its domains of health care, disease prevention and health promotion and its determinants are still scarce. Objective The aim of this study was therefore to analyse the current status of HL among migrants and their descendants from Turkey and from the former Soviet Union (FSU) in Germany and factors associated with it. This has not been studied using large-scale data and bilingual interviews. We differentiate between dimensions of HL, namely the domains of health care, disease prevention and health promotion which goes beyond many previous studies. In addition, we explore new mechanisms by testing the explanatory power of self-efficacy and interethnic contacts for migrants' HL. Methods The study includes 825 first- and second-generation adult migrants from two of the largest immigration groups in Germany, from Turkey and FSU, who were interviewed face-to-face in German, Turkish or Russian in late summer 2020. HL was measured using the HLS19-Q47 instrument. Age, gender, educational level, social status and financial deprivation, chronic illness, health-related literacy skills, self-efficacy, interethnic contacts, migration generation, duration of stay and region of origin were considered as possible determinants. Ordinary least square regressions were estimated. Results The average general HL score was 65.5. HL in health promotion and disease prevention was lower than in health care. Low financial deprivation, health-related literacy skills, and self-efficacy were positively correlated with each HL domain. Educational level, social status, age, gender, duration of stay and interethnic contacts were positively correlated with HL in some domains. Region of origin was only correlated with the domain of disease prevention until interethnic contact was accounted for. Conclusion Our study contributes to the existing knowledge by analyzing different domains of HL and testing its correlations with self-efficacy and interethnic contact among migrants. We reveal that migrants cannot generally be considered as vulnerable for low HL, as oftentimes outlined. There is a need for interventions e.g. to enhance the understanding of health information among subgroups with lower HL.
Environmental integration tool approach: Self-determined commitment and the adoption of pro-environmental behaviors

This paper discusses the role of self-determined commitment in the methodological dynamics of the Environmental Integration Tool Producer (EIT Producer) and its potential impact on the adoption of pro-environmental behaviors by local economy actors in the Global South. This tool is part of the EIT Approach developed by Louvain Coopération, the NGO associated with Université Catholique de Louvain (Belgium), which aims to support social actors in productivity and consumption activities in Africa, Andean America, and Asia. The aim is to highlight the conceptual and methodological elements of the OIE Producer, in order to understand the role of self-determined commitment in the expected ends and in the impact of the tool. The integration between economic development and the environment is a central issue in the challenges of contemporary global society. This article intends to contribute with answers to such challenges, especially with regard to the development of methodologies that are effective in governmental and non-governmental cooperation programs engaged for sustainable development.
Pengaruh Pertumbuhan Aset Dan Resiko Bisnis Terhadap Nilai Perusahaan Pada Perusahaan Manufaktur Sub Sektor Makanan Dan Minuman Yang Terdaftar Di Bursa Efek Indonesia Periode 2016-2020

Penelitian ini bertujuan untuk mengetahui seberapa besar pengaruh Pertumbuhan Aset dan Resiko Bisnis terhadap Nilai Perusahaan pada perusahaan Manufaktur Sub Sektor Makanan dan Minuman yang terdaftar di Bursa Efek Indonesia Periode 2016-2020. Metode penelitian yang digunakan adalah metode Kuantitatif. Populasi dalam penelitian ini adalah Perusahaan Manufaktur Sub Sektor Makanan dan Minuman. Sampel dalam penelitian ini berjumlah 12 Perusahaan dengan penentuan sampel menggunakan Purposive Sampling. Jenis data yang digunakan dalam penelitian ini adalah data sekunder yang di peroleh dari laporan keuangan. Teknik analisis data yang digunakan pada penelitin ini adalah analisis regresi linier berganda. Hasil penelitian ini menunjukkan bahwa secara parsial variabel pertumbuhan aset dan resiko bisnis berpengaruh positif dan signifikan terhadap nilai perusahaan. Hasil penelitian juga menunjukkan bahwa variabel pertumbuhan aset dan variabel resiko bisnis secara simultan berpengaruh signifikan terhadap nilai perusahaan. Besar pengaruh dari variabel pertumbuhan aset dan resiko bisnis terhadap nilai perusahaan adalah sebesar 21,8% sedangkan sisanya sebesar 79,2% dipengaruhi oleh variabel lain yang tidak dijelaskan dalam penelitian ini.
Contamination of Locally Compounded Poultry Feeds and Ingredients by Fungi of the Genus Penicillium and Aspergillus within Three Agro-Ecological Zones of Nigeria

Introduction: Fungi generally are field and storage contaminants of poultry feeds and feed ingredients, the fungal contamination of poultry feeds affects the quality negatively by causing caking, reducing quality and quantity of nutrients, and eventually producing secondary metabolites known as mycotoxins in these products when the environment is conducive. This study was carried out to isolate Aspergillus and Penicillium species from locally compounded poultry feed and feed ingredients that arrived at poultry farms within 30 days. Method: A total of 52 samples of feed (n=13) and feed ingredients (n=39) were collected across 3 agroecological zones (involving 6 states) of Nigeria. Different mycological media was used for isolation, by deploying the pour plate method. The identity of Aspergilli and Penicilli isolates was characterized using macroscopic and microscopic observed features. Results: Hundred per cent of the feed samples were contaminated with Aspergillus species while 63% were contaminated with Penicillium species. Nine species of Aspergillus and five species of Penicillium were detected in the feed and feed ingredients. The highest occurring fungal genus was Aspergillus, specifically, Aspergillus niger and Aspergillus flavus species were the highest occurring species. Penicillium glabrum was the most predominant Penicillium species isolated from the compounded poultry feed and feed ingredient samples. Conclusion: All the feed samples (100%) were contaminated with several species of Aspergillus and Penicillium. The feed ingredients had 100% contamination except for the bone meal samples 78% contamination.
Crystal Shape Control on the Repacking and Jamming of Crystal‐Rich Mushes

The rheology of crustal mushes is a crucial parameter controlling melt segregation and magma flow. However, the relations between mush dynamics and crystal size and shape distribution remain poorly understood because of the complexity of melt‐crystal and crystal‐crystal interactions. We performed analog experiments to characterize the mechanisms that control pore space reduction associated with repacking. Three suspensions of monodisperse particles with different geometries and aspect ratios (1:1, 2:1, 4:1) in a viscous fluid were tested. Our results show that particle aspect ratios strongly control the melt extraction processes. We identify two competing mechanisms that enable melt extraction at grain scale. The first mechanism leads to continuous deformation and melt extraction and is associated with “diffuse” frictional dissipation between neighboring particles. The second is stochastic, localized, and nearly instantaneous and is associated with the development and destruction of force chains percolating through the granular assembly.
Shelf Replenishment Based on Object Arrangement Detection and Collapse Prediction for Bimanual Manipulation

Object manipulation automation in logistic warehouses has recently been actively researched. However, shelf replenishment is a challenge that requires the precise and careful handling of densely piled objects. The irregular arrangement of objects on a shelf makes this task particularly difficult. This paper presents an approach for generating a safe replenishment process from a single depth image, which is provided as an input to two networks to identify arrangement patterns and predict the occurrence of collapsing objects. The proposed inference-based strategy provides an appropriate decision and course of action on whether to create an insertion space while considering the safety of the shelf content. In particular, we exploit the bimanual dexterous manipulation capabilities of the associated robot to resolve the task safely, without re-organizing the entire shelf. Experiments with a real bimanual robot were performed in three typical scenarios: shelved, stacked, and random. The objects were randomly placed in each scenario. The experimental results verify the performance of our proposed method in randomized situations on a shelf with a real bimanual robot.
Intercropping with the potential cadmium hyperaccumulator Solanum photeinocarpum, and its post‐grafting generations, decrease cadmium uptake and promote growth of cherry

Cadmium (Cd)‐contaminated soil has affected the fruit production safety. To decrease the Cd accumulation in the fruits, the effects of intercropping with the potential Cd‐hyperaccumulator Solanum photeinocarpum and its post‐grafting generations on the Cd uptake in cherry (Cerasus pseudocerasus) were studied by the pot experiments. Intercropping increased the biomass of cherry seedlings to some extent, and decreased the biomass of S. photeinocarpum and its post‐grafting generations. Intercropping decreased the Cd contents in cherry seedlings, and increased the Cd contents in S. photeinocarpum and its post‐grafting generations. Compared with their respective monoculture, intercropping decreased the shoot Cd content in cherry seedlings by 31.37%–60.70%, and increased the shoot Cd contents in S. photeinocarpum its post‐grafting generations by 18.50%–28.76%. In addition, intercropping also decreased the root‐to‐shoot Cd translocations in both plant species, and decreased the Cd content in the branches and fruits of fruiting cherry trees and the Cd extractions of S. photeinocarpum and its post‐grafting generations. Therefore, intercropping with S. photeinocarpum and its post‐grafting generations can be used to reduce Cd accumulation in cherry for fruit production safety.
The alpha-effect in galaxies is highly anisotropic

Abstract For the design of galactic dynamo models a knowledge of the complete α-tensor is needed. We determine here its symmetric part with the idea that a homogeneous and isotropic field of explosive forces (created by supernovae or stellar winds) drives a turbulent flow which becomes helical under the influence of rotation and density stratification. Already in the simplest approach that ignores density fluctuations and magnetic diffusivity, and assumes weak stratification and slow rotation, the vertical α-effect exceeds the horizontal one by a factor of 5, α∥/α⊥ ≈ 5. This trend is even amplified if, for small Prandtl number in a more realistic approach, ‘‘negative buoyancy'’ in the galactic isothermal layer is invoked. If, in an alternative model, the turbulence is replaced by random waves the horizontal α⊥ exactly vanishes but not α∥.
Effects of temperature, strain and strain rate on shape memory thermoplastic polyurethane processed by injection molding

Shape memory polymers (SMPs) represent a materials class capable of recovering their initial shape, when submitted to deformations, through an external stimulus. This paper focuses on a Shape Memory Thermoplastic Polyurethane (SMPU), characterized by a one-way shape memory effect (SME) activated by temperature. The material was characterized by Differential Scanning Calorimetry (DSC) to find transition temperature; then, it was manufactured by an injection molding machine to perform a campaign of characterization tests. Thermomechanical tests were conducted varying the prescribed strain (up to 25%, 50%, and 80%), imposed at both different strain rates ( 10 − 3 , 10 − 2 , and 10 − 1 s−1), and temperatures (50°C, 60°C, and 70°C); the results were investigated in terms of shape fixity and shape recovery ratios. An excellent memory capability was observed for all the tested conditions; otherwise, the shape recoverability is strongly influenced by all investigated parameters, especially by the strain rate, resulted to be the most effective one. In fact, the shape recovery ratio can increase as much as 20%, when the strain rate is increased from 10 − 3 to 10 − 1 s−1. An opposite effect was observed with the variation of prescribed strain and temperature, the increase of which reduces the ability of the material to return to its original shape.
Feedback on Pronunciation: Vietnamese EFL Teachers’ Beliefs and Practice

In EFL classrooms today, teachers are facing the challenge of helping their students improve their intelligibility in international communication in English. Feedback is one of the main ways through which teachers are performing the task. However, feedback on students’ English pronunciation has not received commensurate attention in EFL contexts. Aiming to shed some light on this essential but neglected aspect of English language teaching (ETL), this study examines the beliefs and practices of ten experienced teachers of English at a non-English-major university in Vietnam. Findings derived from semi-structured interviews and classroom observations show that teachers largely shared a strong belief in the importance of feedback in learners’ pronunciation development. Teachers were found to mainly focus on instant feedback rather than delayed feedback, and on individual errors rather than collective ones. Findings also indicated that teachers’ approaches to feedback provision diverged greatly, which were confined by their varying expectations in pronunciation pedagogy, different knowledge, and beliefs regarding how to correct, what to correct, and who would benefit from error correction. On the basis of the findings, implications for classroom practices and teacher training were discussed.
Computability: An Introduction to Recursive Function Theory

Preface Prologue, prerequisites and notation 1. Computable functions 2. Generating computable functions 3. Other approaches to computability: Church's thesis 4. Numbering computable functions 5. Universal programs 6. Decidability, undecidability and partical decidability 7. Recursive and recursively enumerable sets 8. Arithmetic and Godel's incompleteness theorem 9. Reducibility and degrees 10. Effective operations on partial functions 11. The second recursion theorem 12. Complexity of computation 13. Further study.
Some notes on beam dynamics due to vertical oscillations in an all-electric storage ring

A document has recently been posted on the arXiv [1], describing analytical formulas and results of particle tracking simulations, for precision tests of numerical integration algorithms for an EDM (electric dipole moment) storage ring. In the context of an all-electric storage ring, the authors cite theoretical formulas by Orlov [2]. However, the reference to Orlov is to a talk at a workshop in 2012, and is unpublished and difficult for independent researchers to access and validate. This note rederives and generalizes some of Orlov's principal results, using a Hamiltonian formalism, and also corrects some details in both Orlov's note [2] and the arXiv post [1].
Development of Spondyloarthritis After COVID-19 in HLA-B27-Positive Monozygotic Twins: Case Reports With Single Cell Transcriptome Profiling

A subset of spondyloarthritis (SpA) called ‘reactive arthritis’ is triggered by causal pathogens, usually bacteria related to venereal disease or gastrointestinal infection. During the outbreak of coronavirus disease 2019 (COVID-19), there have been case reports about SpA after COVID-19, but the causality is still elusive. We described cases of 23-year-old monozygotic twins both diagnosed with SpA after COVID-19. The probable linkage between SpA and COVID-19 was elaborated with our cases as well as literature reviews. Of note, shared genetic traits by monozygotic twins, particularly HLA-B27 positivity, might have contributed to their susceptibility to COVID-19-induced SpA. Moreover, single-cell transcriptome analysis revealed that the transcriptomic profile of peripheral compartment of SpA after COVID-19 was distinctive from that of typical radiographic axial SpA as shown by differential expression of ribosomal protein S26 (RPS26) and small nucleolar RNA host gene 5 (SNHG5) in nearly all subsets of peripheral blood mononuclear cells.