Miracle-dz/UniFAR-FTUs huggingface dataset:
Head growth during neonatal intensive care unit stay is related to neurodevelopmental outcome in preterm infants born small for gestational age

Background: To investigate postnatal growth patterns and their relationship with neurodevelopment in preterm infants born small for gestational age (SGA). Methods: This study analyzed 90 infants born SGA with birth weight <1,500 g or gestational age <32 weeks. Length, weight, and head circumference (HC) were recorded at birth, 35 weeks postmenstrual age (PMA), 40 weeks PMA, and at 4, 9, and 18 months corrected age (CA). Neurodevelopmental outcomes were assessed using the Bayley-III scales at 18 months CA. Results: Z-score of HC in SGA infants increased from birth to 40 weeks PMA. Failure of head growth catch-up to 10th percentile by 4 months CA and all three parameters by 9 months CA and onwards were associated with worse neurodevelopmental outcomes. Z-score changes in head growth between birth and 35 weeks PMA were significantly associated with neurodevelopmental outcome (p=0.006, adjusted odds ratio 6.964, 95% confidence interval: 1.763-27.506). Conclusions: Head growth during neonatal intensive care unit stay were associated with neurodevelopmental outcomes in preterm SGA infants. Preterm SGA infants are predicted to have optimal neurodevelopment at 18 months CA, if the head growth catch-up is achieved by 4 months CA and length and weight by 9 months CA.
INVESTIGATION OF RELATIONSHIP BETWEEN PSYCHOLOGICAL WELL-BEING, SELF ESTEEM, PERCEIVED GENERAL SELF-EFFICACY, LEVEL OF HOPE AND COGNITIVE EMOTION REGULATION STRATEGIES

In this study, the relationship between pre-service teachers' psychological well-being levels and self-esteem, perceived general self-efficacy, cognitive emotion regulation strategies and hope variables were investigated together with how these variables predicted pre-service teachers' psychological well-being. The research was conducted via relational screening model. The research group consists of a total of 403 participants including 206 females and 197 males, who received pedagogical formation education at a university located in Turkey’s Marmara Region, and participants were selected using a simple random sampling method. In the research, Psychological Well-Being Scale (short form), Rosenberg Self-Esteem Scale, General Self-Efficacy Scale, Cognitive Emotion Regulation Scale, the Beck Hopelessness Scale, and Personal Information Form were used as data collection tools. The data obtained were analyzed by multiple linear regression analysis. According to the findings, self-esteem, general self-efficacy, level of hope, positive reappraisal from cognitive emotion regulation strategies, accusing and accepting others significantly predicted psychological well-being. Article visualizations:
Deregulating Innovation Capital: The Effects of the JOBS Act on Biotech Startups

We examine real outcomes for biotech startups going public around the Jumpstart Our Business Startups (JOBS) Act. Reduced compliance costs associate with greater innovation capital formation as biotech IPO volume and proceeds increase after the JOBS Act. Biotechs, which conduct over 30% of IPOs since 2012, go public with products earlier in the FDA approval process and more frequently target rare diseases and cancer. Consistent with our survey evidence that managers use compliance savings to invest in R&D, we link the JOBS Act to post-IPO increases in project-level development, such as new patents, clinical trials, and staffing of laboratories. Post-JOBS Act product candidates are more likely to reach key milestones in the FDA approval process and these startups fail at lower rates. Benefits accrue to shareholders without sacrificing financial reporting quality. Our results demonstrate how tailoring regulations for startups can provide economic and societal benefits.
Added Value of Diaphragm Myofascial Release on Forward Head Posture and Chest Expansion in Patients With Neck Pain: A Randomized Controlled Trial

Farzaneh Haghighat Department of Physical Therapy, School of Rehabilitation Sciences, Shiraz University of Medical Sciences, Shiraz, Iran. 2 Rehabilitation Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Razieh Moradi Shiraz University of Medical Sciences Mohammadreza Rezaie Shiraz University of Medical Science https://orcid.org/0000-0002-1996-9781 Nastaran Yarahmadi Shiraz University of Medical Sciences Farahnaz Ghaffarnejad (  fghafarinejad@yahoo.com ) Department of Physical Therapy, School of Rehabilitation Sciences, Shiraz University of Medical Sciences, Shiraz, Iran. 2 Rehabilitation Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
The Dynamics of Relations Between Systematic Risk, Fundamental Variables and Stock Prices in Pharmaceutical Companies

This study aims to analyze systematic risk, earnings per share, price to earnings ratio, return on equity, and return on assets on stock prices in pharmaceutical companies listed on the Indonesia Stock Exchange. The method used in this research is quantitative method. Data collection techniques are carried out through secondary data that is data obtained indirectly by studying documents related to research. This study uses SPSS 22. Data analysis techniques with multiple linear regression. After conducting research with the hypothesis test found that partially the Return on Equity and Return on Assets variables significantly influence the stock price while the systematic risk variable, Earning per Share and Price Earning Ratio do not significantly influence the stock price. Then simultaneously using the F test, found systematic risk variables, Earning per Share, Price Earning Ratio, Return on Equity and Return on Assets simultaneously or simultaneously have a significant effect on stock prices on Pharmaceutical companies listed on the Indonesia Stock Exchange. This is a factor that should be considered by investors and companies alike, to pay more attention to the factors that contribute to the share price for the long-term sustainability of the company.
PROXIMATE AND MINERAL COMPOSITION OF Pentadiplandra brazzeana STEM BARK

Plants are the cheapest and indispensable constituents of human diets supplying the body nutrients (carbohydrates, protein, fats, amino acids, vitamins) necessary for growth and body development. Therefore, this work was designed to examine the proximate and mineral composition of Pentadiplandra brazzeana stem bark (PBSB). Proximate composition of PBSB revealed the presence of 8.75 % moisture, 91.25 % dry matter, 6.43 % crude protein, 41.03 % crude fibre, 5.70 % ether extract, 12.11 % ash, 17.82 (g/100 g) carbohydrates, 0.47 % total reducing sugar and 632.2 Kj/100g energy respectively. Results on mineral analysis shows that PSSB is abundant in calcium (73.84 mg/100g) followed by phosphorus (41.55 mg/100g), magnesium (32.56 mg/100g), sodium (28.11 mg/100g), zinc (17.56 mg/100g), manganese (10.88 mg/100g), potassium (9.47 mg/100g) and copper (2.33 mg/100g). In order of mineral abundance in PBSB Ca ˃ phosphorus ˃ magnesium ˃ sodium ˃ zinc ˃ manganese ˃ potassium ˃ copper. It was concluded that PBSB is low in protein, energy and some minerals (copper and potassium).
Enhancing the Innovation Performance of Small and Medium-Sized Enterprises Through Network Embeddedness

Based on Resource Based Theory (RBT), the competitiveness of Small and Medium-sized Enterprises (SMEs) depends on the uniqueness of resources used in the production and delivering of goods and services. Moreover, the innovation capability of SMEs is critical in enhancing their uniqueness. Various factors, however, could potentially influence SME innovation performance. This present study thus focuses on how SME innovation performance could be enhanced through the three dimensions of network embeddedness (relational, structural and cognitive). Founded on Resource Dependency Theory (RDT), the study seeks to demonstrate how SMEs could tap into the rich external resources within the networks they are embedded in. The study was based on 388 SMEs selected using a purposive sampling technique. A structured questionnaire was used for the data collection, with the data analyzed by structural equation modeling performed in Amos (v.20). The findings revealed that relational, structural and cognitive embeddedness had a positive effect on innovation performance, while structural embeddedness had the greatest impact on SME innovation performance. As such, SMEs seeking to improve their innovation performance through networks should pay critical attention to the network tie and density. Past studies on network embeddedness and innovation performance have shown conflicting results, and therefore this present study makes a notable contribution to the ongoing debate. Past studies have indicated a positive, negative, inverted u-shape, and even no significant relationship at all between the various dimensions of network embeddedness and innovation performance.
The Importance of Director External Social Networks to Stock Price Crash Risk

Prior research documents that information transmitted via director networks affects firms’ policies and real economic activities. Given a manager’s potential monopoly over firm information, it is important to analyze whether information transmission through director social networks undermines the manager’s control. Specifically, we explore whether information flow through director networks influences managers’ ability to hoard bad news. We predict and find that the extent of external connections of the board of directors is negatively associated with future stock price crash risk. Additional analysis implies that this evidence is driven by firms with more powerful executives, with weaker auditor monitoring, or subject to strong investor protection, and by directors with greater monitoring incentives or responsibilities and directors with less firm-specific knowledge. Collectively, our research lends empirical support for the monitoring view under which better informed directors narrow the scope for bad news hoarding evident in stock price crash risk. In another series of tests, we fail to find evidence consistent with the information leakage view under which directors pass sensitive firm-specific information to connections who trade on the information before its public release. Other analysis helps dispel the concern that the endogenous match between directors and companies is spuriously responsible for our core results. Our empirical findings have important implications on how social networks affect the proper functioning of capital markets.
Achieving Improved Personalization and Energy Efficiency in Cohabited Work-Spaces Through Data-Driven Predictive Control

This paper studies the problem of indoor zone temperature control in shared work-spaces equipped with heterogeneous heating and cooling sources with the goal of increased energy savings and environment personalization. We consider two scenarios to assess the performance of our control strategies. The first scenario requires time-bound pre-cooling/pre-heating of a shared space in preparation for a scheduled activity (Scenario A). The second scenario considers a cohabited work-space where occupants have different temperature preferences (Scenario B). Utilizing an on-campus smart conference room (SCR) as a test-bed, we use data-driven model learning to establish a relationship between the room’s heating, ventilation and cooling (HVAC) operations and the zone temperatures. Next, we use a model predictive control (MPC)-based approach to achieve a desired average temperature while minimizing power consumption (for Scenario A) and minimize the thermal discomfort experienced by individuals based on their temperature preferences (for Scenario B). The experimental results show that for Scenario A, the proposed control policy can save a significant amount of energy and achieve the desired mean temperature in the space fairly accurately. We further note that for Scenario B, the control scheme can achieve a significant spatial differentiation in temperature towards satisfying the occupants’ thermal preferences.
Effect of resource conservation practices on yield attributes and yield in maize based cropping system

The present investigation was carried out during Kharif and Rabi seasons of 2017-18 and 2018-19 at Students Instructional Farm (SIF) of C.S. Azad. University of Agriculture & Technology, Kanpur, entitled “Effect of resource conservation practices on yield attributes and yield in maize based cropping system” The treatments were comprises of three cropping systems (Maize-Wheat, Maize-Field Pea and Maize-Mustard), two moisture conservation practices (Mulching and No mulching) and three nutrient management treatments (100% RDF, 85% RDF+2.5 tonne/ha FYM and 70% RDF+5.0 tonne/ha FYM application of FYM only in kharif season). The field experiment was laid out in Split Plot Design with three replication. The effect of resource conservation practices was observed on yield attributes and yield in different cropping system. The highest growth attributes and yield was observed in mulching and 85% RDF+2.5 tonne/ha FYM treatments.
A Prediction Model of Sufficient Filter Lifespan in Anticoagulation-free CRRT Patients

Background: Anticoagulation-free continuous renal replacement therapy (CRRT) was recommended by the current clinical guideline for patients with increased bleeding risk and contraindications of citrate and resulted in heterogeneous filter lifespan. There was no prediction model to identify the patients would have sufficient filter lifespan when they have to accept CRRT without the use of any anticoagulation. The purpose of our present study is to develop a clinical prediction model of sufficient filter lifespan in anticoagulation-free CRRT patients.Method: Patients who underwent anticoagulation-free CRRT in our center between June 2013 and June 2019 were retrospectively included. The primary outcome was sufficient filter lifespan (≥ 24 hours). The final model was established by using multivariable logistic regression analysis. And, the prediction model was validated in an external cohort. Results: A total of 170 patients were included in the development cohort. Sufficient filter lifespan were observed in 80 patients. The probability of sufficient filter lifespan could be calculated using the following regression formula: P (%) = exp (Z)/1 + exp (Z), where Z = 0.49896-(0.08552*BMI)+(0.44107*T)+(0.03373*MAP)-(0.03389*WBC)+(1.51579*[vasopressor=1])-(0.01132*PLT)+(0.00422*ALP)-(2.66910*pH)-(0.00214*UA)+(0.05992*BUN)+(0.00400*Db)–(0.00014*D-dimer)+(0.02818*APTT). The area under the curve (AUC) of the stepwise model and internal validation model was 0.82 (95%CI [0.76-0.88]) and 0.8 (95%CI [0.74-0.87]), respectively. At the optimal cut-off value of -0.1052, the positive predictive value and the negative predictive value of the stepwise model was 0.77 and 0.79, respectively. The AUC of the external model was 0.82 (95%CI [0.69-0.96]). Conclusion: The use of a prediction model instead of an assessment based only on coagulation parameters could facilitate the identification of the patients with filter lifespan of ≥ 24 hours when they accepted anticoagulation-free CRRT.
Drug Repurposing of β-blocker Propranolol in Osteosarcoma: Preclinical Antitumor Efficacy Alone or in Combination with Chemotherapy.

Background: Osteosarcoma is still associated with poor response to therapy and alarmingly elevated mortality rates, especially in developing countries, highlighting the urgent need of novel therapeutic strategies. Given that β-adrenergic receptor (β-AR) signaling regulates many cellular processes involved in the initiation and progression of cancer, multiple efforts have been made to repurpose non-selective β-blocker propranolol in oncology. Considering the unsatisfied clinical needs of osteosarcoma, we evaluated the in vitro and in vivo antitumoral activity of propranolol as a monotherapy or in combination with metronomic chemotherapy, in β-AR-expressing human osteosarcoma cells. Methods: In vitro anti-osteosarcoma effects of propranolol were assessed on high-density cell growth, chemotaxis, colony-forming ability and three-dimensional spheroids. Cell cycle phase distribution and apoptosis were evaluated using flow cytometry analysis, and quantification of hypodiploid cell population and TUNEL labelling, respectively. Propranolol addition to chemotherapy was evaluated in vitro and in human osteosarcoma xenografts generated in athymic mice.Results: Propranolol significantly impaired MG-63 and U-2 OS cellular growth in a concentration range of 10-100 µM (IC50 ≈ 45µM) and was capable of blocking in vitro protumoral effects triggered by catecholamines. Cytostatic activity of propranolol was associated to reduced mitosis and G0/G1 cell cycle, but not to apoptosis induction. Moreover, β-blocker drastically reduced colony formation, spheroid progression and migration of osteosarcoma cells. Synergistic effects were observed in vitro after combining propranolol with chemotherapeutic agents methotrexate or cisplatin. In vivo, treatment with propranolol (10 mg/kg i.p.), alone and especially in addition to non-interrupted low-dose cisplatin (2 mg/kg i.p.), markedly abrogated xenograft progression, reducing tumor growth rates by 25 or 70%, respectively. After histological analysis, propranolol and cisplatin combined therapy resulted in low tumor mitotic index and increased tumor necrosis. Conclusions: Considering its robust antitumoral effects, β-AR antagonization using β-blocker propranolol seems to be an achievable and cost-effective therapeutic approach to modulate osteosarcoma aggressiveness, in addition to chemotherapy. Propranolol could be proposed as a co-adjuvant agent for the management of osteosarcoma, especially in low- and middle-income countries where access to treatment resources are limited. Further preclinical and clinical studies of propranolol repurposing in osteosarcoma are warranted.
HRM practices and performance management in public service organizations in Bangladesh: An empirical study

This paper assesses the effects of HRM practices on the management performance of public service organizations as public service is believed to safeguard the national property for allocating goods and services timely, and reasonably to the inhabitants of the country especially in a developing country like Bangladesh. The question circling whether the HR practices in public service are sincere for equal and equitable distribution of products and services effectively. In doing so, this study investigated the effectiveness of HR practices and methods on the performance management of public service. The study, through a mixed-method approach, conveniently surveyed a sample of 142 respondents and interview drawn from seven key informants of two Bangladesh Civil Service (BCS) cadre from Chittagong, the second-largest city of the country. The study shows the differences in the effects of HRM practices that employee training positively and commensurate compensation negatively predict employee performance, respectively, however, performance appraisal feedback is not a significant predictor. The study drawn the implications for HRM practices in BCS organization and encouraged future scholars to further examine these differences.
Pathological α-synuclein triggers synaptic NMDA receptor dysfunction through altered trafficking

Background α-Synuclein misfolding and aggregation contribute to synaptic dysfunction in synucleinopathies, including Parkinson’s disease. However, the mechanism underlying the effect of α-synuclein on synaptic components remains unclear. Since the N-methyl-D-aspartic acid receptor (NMDAR) plays a key role in glutamate synapse pathophysiology, we here investigated its surface dynamics and functional distribution in neurons exposed to various pathological α-synuclein forms. Methods A combination of single-molecule tracking, immunochemistry, immunoblot and calcium imaging approaches were used to assess the changes in NMDAR membrane dynamics and functions. The NMDAR alterations were evaluated in rat cultured hippocampal networks, in which α-synuclein mutants were overexpressed or exposed to α-synuclein proteins (monomeric/PFF α-synuclein). The surface dynamics of NMDAR subtype was artificially tuned in order to test its instrumental role. Results We observed that mutant α-synuclein (A53T-α-synuclein) restricted NMDAR surface trafficking and impaired synaptic function. In contrast, wild-type α-synuclein did not affect synaptic NMDAR. Further, we found that chronic exposure to α-synuclein preformed fibrils induced molecular dysfunctions that mainly targeted the GluN2B-NMDAR subtype. The deficits of synaptic NMDAR have also been found in A53T transgenic mice α-synuclein. Upon fine-tuning of the surface dynamics of GluN2B-NMDAR, pathological α-synuclein gradually lost its synaptic toxicity. Conclusions Our findings indicate that pathological α-synuclein alters GluN2B-NMDAR synaptic dynamics and organization, which leads to glutamate synapse dysfunction.
Detailed Experimental Study of the Flow in a Turbine Rear Structure at Engine-Realistic Flow Conditions

A good aerodynamic design of the turbine rear structure (TRS) is crucial for improving efficiency and reducing emissions from aero-engines. This paper presents a detailed experimental evaluation of an engine-realistic TRS which was studied in an engine-realistic rig at Chalmers University of Technology, Sweden. The TRS test section was equipped with three types of outlet guide vanes (OGVs) which are typical of modern state-of-the-art TRS: regular vanes, thickened vanes, and vanes with an engine-mount recess (a shroud bump). Each of the three vane geometries was studied under on-design and off-design conditions at a fixed flow Reynolds number of 235,000. The study shows that the off-design performance of the TRS strongly depends on the presence of the local flow separation on the OGV suction side near the hub, which is greatly affected by the vane pressure distribution and inlet conditions. Similarly, the OGVs with increased thickness and with a vane shroud bump are shown to affect the performance of the TRS by influencing the losses on the OGV suction side near the hub. Furthermore, the presence of the bump is shown to have a noticeable upstream influence on the outlet flow from the low-pressure turbine and a noticeable downstream influence on the outlet flow from the TRS.
Admission Exam and Preparatory Year Scores’ Association with Performance in Basic Science Courses in Health Science Colleges

Aliaa Amr Alamoudi (  aaalamoudi2@kau.edu.sa ) King Abdulaziz University https://orcid.org/0000-0001-5428-8853 Hind Ibrahim Falattah King Abdulaziz University Faculty of Medicine Basmah Medhat Eldakhakhny King Abdulaziz University Faculty of Medicine https://orcid.org/0000-0002-6962-5848 Fatemah Omar kamel King Abdulaziz University Faculty of Medicine Lana Adey AlSawwa King Abdulaziz University Faculty of Medicine Ayman Zaky Elsamanoudy King Abdulaziz University Faculty of Medicine
Decrease of Polycyclic Aromatic Hydrocarbons (PAHs) Associated with Atmospheric Aerosols and Deposited Particulate Matter in Atmospheric Environment

大気粉 塵 中(小 径粉 塵;粒 径7.0μm未 満,大 径粉 塵;粒 径7.0μm以 上)お よび堆 積粉塵 中の 13種 類の 多環芳 香族 炭化 水素 類(PAHs)の 含 有量 の減 少特性 を調 査 した. 方 法 と して は,大 気 粉塵 お よび 堆積粉 塵 を郊外 地域 で捕 集,捕 集 後 にその場 に数 日お き減少 量 を測定 す る ことに よって評価 した. 測 定 は一 年間継 続 的 に行 い減 少速 度係数kを 求 め,各 測 定期 間 にお け る,全PAHsのkの 中 央 値kmedを 用 い て評価 した. kmedは 最大 で0.3d-1で あっ た. kmedは 全体 と して小 径粉 塵の値 が大 きか っ た(0.1~0.3d-1). 季 節 性 に関 して は小径 粉塵 は夏 に値 が大 き く冬 に小 さい とい う傾 向 が明確 に得 ら れ たが,大 径,堆 積 は必 ず しも明確 な傾 向 は得 られ なか った. 堆 積 粉塵 に関 しては予想 に反 して冬 に値 が高 い傾 向 が得 られ た. PAHs含 有 量 につ いては,小 径 粉塵 につ い て は夏 に低 く冬 に高 い とい う季節 性 が見 られ,本 観 測 で得 られ たkmedと 強 い相 関 を持 った. こ の ことか ら大 気 中のPAHsの 濃 度 の季節変 動 は粉塵 付着 態PAHsの 大気 中 での減少 特性 に強 く依存 して い るこ とが示 唆 された. 本 研究 の結果 によ り大 気 中のPAHsの 含有 量 お よびそのパ ター ンの変化 に は,そ の大気 中で の減少 が 強 く影響 を与 えて い る可 能性 が あ るこ とが示 された.