Miracle-dz/UniFAR-FTUs huggingface dataset:
Hypoplastic myelodysplastic syndrome and acquired aplastic anemia: Immune-mediated bone marrow failure syndromes (Review)

Hypoplastic myelodysplastic syndrome (hMDS) and aplastic anemia (AA) are rare hematopoietic disorders characterized by pancytopenia with hypoplastic bone marrow (BM). hMDS and idiopathic AA share overlapping clinicopathological features, making a diagnosis very difficult. The differential diagnosis is mainly based on the presence of dysgranulopoiesis, dysmegakaryocytopoiesis, an increased percentage of blasts, and abnormal karyotype, all favouring the diagnosis of hMDS. An accurate diagnosis has important clinical implications, as the prognosis and treatment can be quite different for these diseases. Patients with hMDS have a greater risk of neoplastic progression, a shorter survival time and a lower response to immunosuppressive therapy compared with patients with AA. There is compelling evidence that these distinct clinical entities share a common pathophysiology based on the damage of hematopoietic stem and progenitor cells (HSPCs) by cytotoxic T cells. Expanded T cells overproduce proinflammatory cytokines (interferon-γ and tumor necrosis factor-α), resulting in decreased proliferation and increased apoptosis of HSPCs. The antigens that trigger this abnormal immune response are not known, but potential candidates have been suggested, including Wilms tumor protein 1 and human leukocyte antigen class I molecules. Our understanding of the molecular pathogenesis of these BM failure syndromes has been improved by next-generation sequencing, which has enabled the identification of a large spectrum of mutations. It has also brought new challenges, such as the interpretation of variants of uncertain significance and clonal hematopoiesis of indeterminate potential. The present review discusses the main clinicopathological differences between hMDS and acquired AA, focuses on the molecular background and highlights the importance of molecular testing.
Deterioration of sugar maple following logging damage

The northern hardwood forest comprises about 9 million acres in the Lake States region. Most of this timber is in Upper Michigan and Wisconsin, with lesser amounts in Minnesota, It consists primarily of sugar maple (Acer saccharum Marsh.), yellow birch (Betula alleghaniensis Britt,), basswood (Tilia americana L.), and often eastern hemlock (Tsuga canadensis (L.) Carr. ). Although yellow birch is of considerable economic value in this forest type, it is secondary in importance to sugar maple. Only a small part of the area is in old-growth forest, and at the present rate of cutting these stands will soon disappear. However, many tracts of saplings that developed after early logging operations have grown to pole size and now constitute an important area of near- merchantable sawtimber (3). In addition, some areas have been logged on a partial-cut System, leaving rather extensive reserve stands, This system is being applied to a progressively greater extent each year.
1700V, 5.5mOhm-cm2 4H-SiC DMOSFET with Stable 225°C Operation

We report a 1700V, 5. 5mΩ-cm2 4H-SiC DMOSFET capable of 225°C operation. The specific on-resistance of the DMOSFET designed for 1200V applications is 8. 8mΩ-cm2 at 225°C, an increase of only 60% compared to the room temperature value. The low specific on-resistance at high temperatures enables a smaller die size for high temperature operation. Under a negative gate bias temperature stress (BTS) at VGS=-15 V at 225°C for 20 minutes, the devices show a threshold voltage shift of ΔVTH=-0.25 V demonstrating one of the key device reliability requirements for high temperature operation.
Driving in a simulator versus on-road: The effect of increased mental effort while driving on real roads and a driving simulator

The objective of this thesis is to study human response to increased workload while driving in a driving simulator compared to real world behavior. Driving simulators are a powerful research tool, providing nearly complete control over experimental conditions— an ideal environment to quantify and study human behavior. However, participants are known to behave differently in a driving simulator than in an actual real-world scenario. The same participants completed both on-road and virtual drives of the same degree of roadway complexity, with and without a secondary task conditions. Data were collected to describe how the participants’ vehicle-handling, gaze performance and physiological reactions changed relative to increases in mental workload. Relationships between physiology and performance identified physiological, performance, and gaze-related metrics that can show significant effects of driving complexity, environment, and task. Additionally, this thesis explores the inadequacy of multinomial predictive models between the simulator and instrumented vehicle. Relative validity is established in the performance-physiology relationship for onand off-road fixation frequencies, but few correlations between the simulator and instrumented vehicle are apparent as mental workload increases. These findings can be applied to the real world by providing specific variables that are adequate proxies to detect changes in driver mental workload in on-road driving situations; valuable for in-vehicle driver assistance system research. Overall, the simulator was a suitable proxy to detect differences in mental workload in driving task; and initial steps have been taken to establish validity, and to supplement on-road driving research in these high-demand driving scenarios.
Gryon aetherium Talamas (Hymenoptera, Scelionidae): Parasitoid of Bagrada hilaris (Burmeister) (Hemiptera, Pentatomidae) Adventive in Chile

A parasitoid wasp, Gryon aetherium Talamas (Hymenoptera, Scelionidae), was reared from eggs of the invasive stink bug Bagrada hilaris (Burmeister) (Hemiptera, Pentatomidae) in Chile. The identification of G. aetherium, which is under study as a biological control agent, was made with morphological and molecular data in the context of a recent taxonomic treatment of this species. The presence of an adventive population of G. aetherium in South America has implications for biological control of B. hilaris in Chile, and other countries on the continent, where this stink bug may become a pest.
Alterations in magnetic resonance imaging characteristics of bioabsorbable magnesium screws over time in humans: a retrospective single center study

Abstract Objectives This study aimed to examine the alterations in magnetic resonance imaging (MRI) characteristics of bioabsorbable magnesium (Mg) screws over time in a single center study in humans. Methods Seventeen patients who underwent medial malleolar (MM) fracture or osteotomy fixation using bioabsorbable Mg screws and had at least one postoperative MRI were included in this retrospective study. Six of them had more than one MRI in the postoperative period and were subject of the artifact reduction measurements. 1.5T or 3T MRI scans were acquired in different periods in each patient. The size and extent of the artifact were assessed independently by two experienced radiologists both quantitatively (distance measurement) and qualitatively (Likert scale). Results In the quantitative measurements of the six follow-up patients the screw’s signal loss artifact extent significantly decreased over the time, regardless of the MRI field strength (p<0.001). The mean artifact reduction was 0.06 mm (95% confidence interval [CI]: 0.05–0.07) for proton density weighted [PDw] and 0.04 mm (95% CI: 0.03–0.05) for T1 weighted (T1w) sequences per week. The qualitative assessments similarly showed significant artifact reduction in all MRI sequences. Different imaging findings, like bone marrow edema (BME), liquid collections, and gas formation were reported. The overall inter-reader agreement was high (κ=0.88, p<0.001). Conclusions The time-dependent artifact reduction of Mg screws in postoperative controls might indicate the expected self-degradation of the Mg implants. In addition, different MRI findings were reported, which are characteristic of Mg implants. Further MRI studies are required to get a better understanding of Mg imaging properties.
Slide roof system for dynamic response reduction

A slide roof system (SRS) is proposed to reduce the dynamic response of buildings to earthquake excitations. A SRS consists of a roof structure, springs and friction materials, providing mass, stiffness and damping, respectively. The method of optimization of stiffness and friction coefficient for the SRS is introduced. A numerical analysis of an eight‐story frame structure subjected to ground motions and shaking table tests of a five‐story frame was carried out to study the effectiveness of the SRS. The results show that the SRS can reduce the maximum dynamic response as much as 60–70% in the first resonate band and 35–50% in the second resonate band. Copyright © 2007 John Wiley & Sons, Ltd.
Diagnosed with myeloma before age 40.

In the United States, the average age at diagnosis with multiple myeloma is 69 years, and 95% of newly diagnosed patients are $50 years. Because of this demographic, there is only limited information on the biology and clinical management of younger individuals. It is estimated that there will be 35000 new cases of multiple myeloma in 2021; 1500 to 2000 of those cases will be in patients in their 30s and 40s. Unfortunately, there is no established cure for multiple myeloma; however, access to modern and effective drugs has translated into a significantly improved overall survival for patients with multiple myeloma. Indeed, an otherwise healthy younger individual diagnosed with multiple myeloma has a projected average overall survival of $10 years. Overall survival will likely be even greater assuming that many new drugs will be developed during this timeframe. Altogether, these factors contribute to a rising prevalence in the general population of the number of patients living with multiple myeloma. Indeed, . 150000 individuals are currently living with multiple myeloma in the United States. Although no official statistics are available, it seems reasonable to estimate that 10000 to 20000 of those individuals are in their 30s and 40s. When multiplying the number of patients with long overall survival (median overall survival $10-20 years), the number of person-years is substantial. Despite these facts, limited attention has been paid to this group of patients.
Impact of Internet Use on Mental Health among Elderly Individuals: A Difference-in-Differences Study Based on 2016–2018 CFPS Data

The number of elderly Internet users has increased significantly in the past few years. However, the impact of Internet use on mental health remains unclear. In this study, we performed a difference-in-differences analysis using data from the 2016 and 2018 waves of the China Family Panel Studies (CFPS) to evaluate the impact of Internet usage on mental health among elderly individuals. A total of 5031 validated respondents were included to explore the relationship between Internet use and reduced levels of depression as well as improved life satisfaction among elderly individuals. The results showed that Internet use significantly reduced depression levels. Unexpectedly, Internet use was not found to improve life satisfaction. Moreover, discontinuing Internet use was not significantly associated with improvements in depression or life satisfaction. More research is needed to fully elucidate the relationship between Internet use and depression levels, as well as life satisfaction among elderly individuals.
Integrating Research-informed Teaching into Sustainable Construction Education

Abstract Research-informed teaching is increasingly regarded as an effective approach to improving the quality of teaching and student learning in higher education. However, the relationship between research and teaching is controversial, with profound differences existing between different disciplines. This paper aims to enhance the student learning experience by examining the drivers, barriers and practices in relation to research-informed teaching. The research used a broad case study research design, focusing on the sustainable construction discipline taught at a new (post-1992) university in the UK. The results reveal that despite sector, institutional and disciplinary drivers in favour of research-informed teaching, significant barriers existed to the implementation of such an approach among both lecturers and students. A key barrier was found to be the complicated and confusing debate on the research-teaching nexus, which hampered communication between institution, lecturers and students. Further, the professional obligations and academic interests of lecturers were interwoven with the learning and career expectations of students, resulting in a complex network of relationships between research and teaching within the discipline. The paper identifies strategies for advancing research-informed teaching which require simultaneous input and support from a wide range of stakeholders including industry professionals, university policymakers, lecturers and students. Guidance on integrating the approach of research-informed teaching into sustainable construction education is provided.
NEURAL NETWORK MODEL FOR FLUIDISED BED DRYERS

The application of an artificial neural network (ANN) to model a continuous fluidised bed dryer is explored. The ANN predicts the moisture and temperature of the output solid. A three-layer network with sigmoid transfer function is used. The ANN learning is made by using a set of data that were obtained by simulating the operation by a classical model of dryer. The number of hidden nodes, learning coefficient, size of learning data set and number of iterations in the learning of the ANN were optimised. The optimal ANN has five input nodes and six hidden nodes. It is able to predict, with an error less than 10%, the moisture and temperature of the output dried solid in a small pilot plant that can treat up to 5 kg/h of wet alpeorujo. This is a wet solid waste that is generated in the two-phase decanters used to obtain olive oil.
Carbon Dioxide Effects on the Flammability Characteristics of Biogas

Flammability limits and flame speed of methane-carbon dioxide-air mixtures have been studied to understand the effect of carbondioxide on the flammability characteristic of biogas. The fuel of biogas discussed in this study was made by mixing gases of methane and carbon dioxide. The carbon dioxide was varied from 0% (by volume) untill reach the flammability limit of the stoikhiometri biogas-air mixtures. The observation was done using a cubic combustion bomb with the dimension of 500 mm x 200 mm x 10 mm with the initial condition being at room temperature and atmospheric pressure. The ignitor was set at the top of combustion bomb, so the flame propagated downward. Base on the observation results, the presence of carbon dioxide in the fuel ofbiogas caused the flammability limits of biogasair mixture narrower. The biogas-air mixture was still flammable with the highest content of carbon dioxide of 62.5 %vol when the mixture was sthoichiometri. Compared to methane-air mixture, the presence of carbon dioxide in biogas caused a reduction in the flame speed. The stoichiometri mixture has the highest flame speed when the carbon dioxide was not present in the fuel. However, when the carbon dioxide was added in the fuel, the rich mixture has the highest flame speed. This is a consequence of the rich biogas-air mixture having a higher fraction of the carbon dioxide components from the fuel compared to the stoichiometri and lean biogas-air mixture. The result also indicated that at the upper limit the flame still propagated downward to closed to the endwall. However, at the lower limit (lean mixtures), the flame did not intend to propagate downward, it was just at the top and propagate sideward.
Maintenance Engineering as a Basic Tool for Maximum Production.

As a result of rapid advances in modernization schemes during the past four decades, industrial maintenance has become so sophisticated that trained personnel are necessary. Maintenance, an aspect of the engineering discipline, is rooted in engineering practice and is so important for the smooth running survival of any industrial set up. Discussion in this review covers a range of experience in maintenance systems for equipment or machines in industry. All over the world, industries have various ways of organizing maintenance activities to sustain the life span of equipment or machines and for greater efficiency and productivity. The failure of most industries today results from of lack of adequate maintenance practice, Experience has shown that many of our industrial machines break down when they still should be expected to be at the peak of their production performances. Outcome effects are that most industries start to run at a huge loss when they were expected to make profit. Consequently, a maintenance engineering culture should be properly in practice in all national industries.
IMPACT OF CLOUD ASPECTS ON IT EFFECTIVENESS

Against the backdrop of new economic realities, one of the larger forces that is affecting businesses worldwide is cloud computing, whose benefits include agility, time to market, time to capability, reduced cost, etc. The intent of this research was to contribute to the body of knowledge that could be applied by researchers, businesses, and IT organizations alike to achieve optimal results by focusing on the key aspects of cloud based services and solutions. The study findings provided statistical evidence that cloud connectivity, software and application modularity within cloud, as well as software and systems compatibility within cloud have strong positive correlations on IT effectiveness. Also, having multiple interfaces for users to access applications on cloud, portability across multiple cloud providers, legacy systems not hampering development of new applications in cloud, and multi.protocol support are identified as the top four aspects which has much higher positive impact on IT effectiveness.
Investigating the Relationship between White Matter Connectivity and Motivational Circuits in Subjects with Deficit Schizophrenia: A Diffusion Tensor Imaging (DTI) Study

Deficit schizophrenia is a subtype of schizophrenia presenting primary and enduring negative symptoms (NS). Although one of the most updated hypotheses indicates a relationship between NS and impaired motivation, only a few studies have investigated abnormalities of motivational circuits in subjects with deficit schizophrenia (DS). Our aim was to investigate structural connectivity within motivational circuits in DS. We analyzed diffusion tensor imaging (DTI) data from 46 subjects with schizophrenia (SCZ) and 35 healthy controls (HCs). SCZ were classified as DS (n = 9) and non-deficit (NDS) (n = 37) using the Schedule for Deficit Syndrome. The connectivity index (CI) and the Fractional Anisotropy (FA) of the connections between selected brain areas involved in motivational circuits were examined. DS, as compared with NDS and HCs, showed increased CI between the right amygdala and dorsal anterior insular cortex and increased FA of the pathway connecting the left nucleus accumbens with the posterior insular cortex. Our results support previous evidence of distinct neurobiological alterations underlying different clinical subtypes of schizophrenia. DS, as compared with NDS and HCs, may present an altered pruning process (consistent with the hyperconnectivity) in cerebral regions involved in updating the stimulus value to guide goal-directed behavior.
Indole as a new tentative marker in exhaled breath for non-invasive blood glucose monitoring of diabetic subjects

Blood glucose monitoring (BGM) is the most important part of diabetes management. In classical BGM, glucose measurement by test strips involves invasive finger pricking. We present results of a clinical study that focused on a non-invasive approach based on volatile organic compounds (VOCs) in exhaled breath. Main objective was the discovery of markers for prediction of blood glucose levels (BGLs) in diabetic patients. Exhaled breath was measured repeatedly in 60 diabetic patients (30 type 1, 30 type 2) in fasting state and after a standardized meal. Proton transfer reaction time of flight mass spectrometry was used to sample breath every 15 min for a total of 6 h. BGLs were tested in parallel via BGM test strips. VOC signals were plotted against glucose trends for each subject to identify correlations. Exhaled indole (a bacterial metabolite of tryptophan) showed significant mean correlation to BGL (with negative trend) and significant individual correlation in 36 patients. The type of diabetes did not affect this result. Additional experiments of one healthy male subject by ingestion of lactulose and 13C-labeled glucose (n = 3) revealed that exhaled indole does not directly originate from food digestion by intestinal microbiota. As indole has been linked to human glucose metabolism, it might be a tentative marker in breath for non-invasive BGM. Clinical studies with greater diversity are required for confirmation of such results and further investigation of metabolic pathways.
An analytical hierarchy process‐based tool to evaluate value systems for lean transformations

Purpose – True lean transformation has proved notoriously difficult for non‐Toyota companies. One hypothesis is excessive focus on tools/techniques without building the necessary organizational culture. However, empirical evidence is not available to confirm (or refute) this hypothesis. The complex question of the relationship between an organization's culture and its ability to implement lean is a long‐term effort. As a first step, the purpose of this paper is to offer the results of a survey conducted to discover the relative (in)consistency of lean cultures in terms of values held explicitly.Design/methodology/approach – A survey tool was developed to compare what employees of lean (or attempting to be lean) organizations say explicitly about what their culture values. The Toyota Way, considered by Toyota as guiding its values, was used as the basis to develop the survey which was administered to individuals in several different organizations.Findings – A higher degree of lean implementation in a compa.
Pitfalls of staircase meshing

The authors demonstrate that staircased approximations to curved or oblique electromagnetic interfaces yield poor accuracy unless the user has truly unlimited computer resources for two simple geometries: a conducting strip and a circular conducting cylinder. Conformal meshing reduces by a factor of four the resolution required in each direction. A conformally meshed circular cylinder model yields good radar cross section (RCS) predictions with only eight cells per wavelength. >
Sustained TNF signaling is required for the synaptic and behavioral response to acute stress

Acute stress triggers plasticity of forebrain synapses as well as behavioral changes. Here we reveal that Tumor Necrosis Factor α (TNF) is a required downstream mediator of the stress response in mice, necessary for stress-induced synaptic potentiation in the ventral hippocampus and for an increase in anxiety-like behaviour. Acute stress is sufficient to activate microglia, triggering the long-term release TNF. Critically, on-going TNF signaling in the ventral hippocampus is necessary to sustain both the stress-induced synaptic and behavioral changes, as these could be reversed hours after induction by antagonizing TNF signaling. This demonstrates that TNF maintains the synaptic and behavioral stress response in vivo, making TNF a potential novel therapeutic target for stress disorders.