Miracle-dz/UniFAR-FTUs huggingface dataset:
Synchronicity and Geographic Variation in Oregon White Oak Acorn Production in the Pacific Northwest

Abstract We explored geographic patterns and synchrony of Oregon white oak (Quercus garryana) acorn production over 8 years from Vancouver Island, British Columbia to Medford, Oregon. We divided our data into geographic areas: Puget-Willamette Trough, Columbia Gorge-East Cascades (Eastside) xeric, Eastside mesic, Cascade Mountain foothills, Roseburg, and Medford to compare annual acorn production among areas. We observed high within-area synchrony, but synchrony across areas was only apparent in 2004 and 2006 (high production), and 2005 (low production). Correlogram analysis indicated significant acorn crop correlation throughout the Puget-Willamette Trough, but synchrony was higher over greater distances among stands than among trees. Relationships between acorn production and mean monthly temperature or precipitation were examined with correlation analyses for each month between floral initiation and acorn maturation over 8 years of observations. Acorn production in the Puget-Willamette Trough was negatively correlated with spring precipitation, possibly due to an effect on floral processes, and winter temperature, which might relate to bud chilling requirements. In Eastside uplands, June precipitation positively correlated with current acorn production, but negatively correlated with the following year's production suggesting a climatically mediated depression by one year's production on that in the following year. Eastside production negatively correlated with precipitation in March suggesting precipitation interferes with floral processes at that time. We developed predictive linear regression models for the two analysis areas with largest sample sizes. Oregon white oak masting is similar to that in other white oaks in terms of periodicity and the effects of spring weather, but is also influenced by other weather related factors following floral induction.
Assessment of mean platelet volume (MPV) in subjects with Type 2 Diabetes Mellitus (T2DM) in a rural backdrop of central India

Introduction: Diabetes is a public health problem. Altered platelet morphology and function have been reported as a cause of microvascular and macrovascular complications in patients with diabetes mellitus. Aim: We conducted a cross-sectional study to compare MPV in type 2 diabetics (T2DM) and non-diabetics and study the relationship between MPV and glycemic control (HbA1C) in patients with T2DM in a rural backdrop of central India. Methods: Participants were distributed into 2 groups: the study group of patients with T2DM (n = 98) and control group with non-diabetics (n = 98). The study group were further sub-grouped as uncontrolled group (HbA1c > 7%) of diabetic patients and controlled group (HbA1c ≤ 7%) of diabetic patients.MPV was determined by cell counter. Study group and control group were then compared with regards to MPV and HbA1c. Results: We found significantly higher MPV in diabetics as compared to non-diabetics. Also, we found a positive co-relation between MPV and HBA1c. One % increase in Hb1Ac led to an increase in 1.45 fl (1.37-1.52) of MPV. It is hypothesized that platelet hyperactivity in patients with T2DM is related with factors such as hyperglycemia, hyperlipidemia, insulin resistance, and antioxidant and inflammatory conditions. Conclusion and implications: This study can be of help to physicians, consumers and policy-makers to decide whether MPV can be incorporated as a tool to assess and monitor the development of microvascular and macrovascular complications of T2DM.
Halting the vicious cycle within the multiple myeloma ecosystem: blocking JAM-A on bone marrow endothelial cells restores angiogenic homeostasis and suppresses tumor progression

Interactions of malignant multiple myeloma (MM) plasma cells with the microenvironment control MM plasma-cell growth, survival, drug-resistance and dissemination. As microvascular density increases in the bone marrow in MM, we investigated whether bone marrow MM endothelial cells control disease progression via the junctional adhesion molecule-A (JAM-A). Membrane and cytoplasmic JAM-A levels were upregulated in MM endothelial cells in 111 patients with newly diagnosed MM and in 201 with relapsed/refractory MM compared to the levels in patients with monoclonal gammopathy of undetermined significance and healthy controls. Elevated membrane expression of JAM-A on MM endothelial cells predicted poor clinical outcome. Mechanistically, addition of recombinant JAM-A to MM endothelial cells increased angiogenesis, whereas inhibition of this adhesion molecule impaired angiogenesis and MM growth in two-dimensional and three-dimensional in vitro cell cultures and chorioallantoic membrane assays. To corroborate these findings, we treated MM-bearing mice with a JAM-A-blocking monoclonal antibody and demonstrated impaired MM progression, corresponding to decreased MM-related vascularity. These findings support the concept that JAM-A is an important mediator of MM progression through facilitating MM-associated angiogenesis. Elevated JAM-A expression on bone marrow endothelial cells is an independent prognostic factor for the survival of both patients with newly diagnosed MM and those with relapsed/refractory MM. Blocking JAM-A restricts angiogenesis in vitro, in utero and in vivo and represents a suitable druggable molecule to halt neo-angiogenesis and MM progression.
Fruits in the Diets of Neotropical Migrant Birds in Costa Rica

We used fecal samples collected from birds captured in mist nets to determine the occurrence of fruit in the diets of neotropical migrant birds (species that breed in North America and winter in Central and South America) at six study sites in Costa Rica. A total of 1016 migrants representing 30 species were captured. Fecal samples were collected from 85 percent of all birds captured. Fruits (seeds, pulp) occurred in 58 percent of all fecal samples; the proportion of fecal samples containing fruit ranged from 0 percent (9 species) to over 90 percent (9 species). Individual fecal samples contained seeds from as many as 4 species of plants. At least 98 plant species from at least 29 plant families were represented in fecal samples. Species of Melastomataceae accounted for 37 percent and those of Rubiaceae for 16 percent of all species recorded. Number of fruit species in diets of individual migrant species ranged from 0 (9 species) to 63 (Swainson's Thrush, Catharus ustulatus). Our data demonstrate that some migrants may rival permanent residents in the diversity of fruits they consume. A shift to increased frugivory in the late dry season, as birds were preparing to migrate north, was noted.
Concomitant management of renal calculi and recurrent ureteropelvic junction obstruction with percutaneous nephrolithotomy and antegrade balloon dilation

Objective This study aimed to present our experience of concomitant management of renal calculi and recurrent ureteropelvic junction obstruction (UPJO) with percutaneous nephrolithotomy (PCNL) and antegrade balloon dilation. Methods We retrospectively reviewed 31 patients who underwent PCNL and antegrade balloon dilation for treatment of renal calculi and recurrent UPJO. The inclusion criterion was the presence of UPJO after failed pyeloplasty with ipsilateral renal calculi. Success was defined as achievement of both symptomatic and radiographic resolution of any stones and obstruction. Results All operations were successful without grade III or higher postoperative complications. A stone-free status was observed in all patients and the overall success rate of the procedure was 87.1% (27/31). The success rate of the procedure was significantly higher in patients with mild or moderate preoperative hydronephrosis (96%) than in those with high-grade preoperative hydronephrosis (50%). Moreover, the success rate of the procedure was lower in patients with poor preoperative renal function (0%) than in those with good or moderate renal function (93.1%). Conclusion Combined PCNL and antegrade balloon dilation management represents a safe and effective approach for patients with renal calculi and recurrent UPJO after failed pyeloplasty.
Plasticity of Coagulase-Negative Staphylococcal Membrane Fatty Acid Composition and Implications for Responses to Antimicrobial Agents

Staphylococcus aureus demonstrates considerable membrane lipid plasticity in response to different growth environments, which is of potential relevance to response and resistance to various antimicrobial agents. This information is not available for various species of coagulase-negative staphylococci, which are common skin inhabitants, can be significant human pathogens, and are resistant to multiple antibiotics. We determined the total fatty acid compositions of Staphylococcus auricularis, Staphylococcus capitis, Staphylococcus epidermidis, Staphylococcus haemolyticus, Staphylococcus hominis, Staphylococcus saprophyticus, and Staphylococcus aureus for comparison purposes. Different proportions of branched-chain and straight-chain fatty acids were observed amongst the different species. However, growth in cation-supplemented Mueller–Hinton broth significantly increased the proportion of branched-chain fatty acids, and membrane fluidities as measured by fluorescence anisotropy. Cation-supplemented Mueller–Hinton broth is used for routine determination of antimicrobial susceptibilities. Growth in serum led to significant increases in straight-chain unsaturated fatty acids in the total fatty acid profiles, and decreases in branched-chain fatty acids. This indicates preformed fatty acids can replace biosynthesized fatty acids in the glycerolipids of coagulase-negative staphylococci, and indicates that bacterial fatty acid biosynthesis system II may not be a good target for antimicrobial agents in these organisms. Even though the different species are expected to be exposed to skin antimicrobial fatty acids, they were susceptible to the major skin antimicrobial fatty acid sapienic acid (C16:1Δ6). Certain species were not susceptible to linoleic acid (C18:2Δ9,12), but no obvious relationship to fatty acid composition could be discerned.
How bodily expressions of emotion after norm violation influence perceivers’ moral judgments and prevent social exclusion: A socio-functional approach to nonverbal shame display

According to a socio-functional perspective on emotions, displaying shame with averted gaze and a slumped posture following a norm violation signals that the person is ready to conform to the group’s moral standards, which in turn protects the person from social isolation and punishment. Although the assumption is intuitive, direct empirical evidence for it remains surprisingly limited and the mediating social-psychological mechanisms are poorly understood. Therefore, three experimental studies were conducted to investigate the social function of nonverbal displays of shame in the context of everyday norm violations. In Study 1, participants evaluated ten different expressions of emotion in regard to their affective valence, arousal, dominance, as well as social meaning in the context of norm violations. Displays of shame and sadness were seen as the most similar expressions with respect to the three affective dimensions and were perceived to communicate the perpetrator’s understanding of the group’s moral standards most effectively. In Study 2, participants read vignettes concerning norm violations and afterward saw a photograph of the perpetrator displaying nonverbal shame, sadness or a neutral expression. Perpetrators’ displays of shame and sadness increased perceived moral sense and amplified the observers’ willingness to cooperate with the perpetrators. However, neither display weakened the observer’s willingness to punish the perpetrator. In Study 3, the perpetrator was shown to display shame, sadness, anger or a neutral expression after getting caught at mild or severe norm violation. The results replicated previous findings but revealed also that the social effects of shame and sadness displays on punitive and cooperative intentions were mediated by different social appraisals. For example, display of shame uniquely reduced punitive intentions by increasing the perpetrator’s perceived moral sense, whereas expressions of both shame and sadness evoked empathy in the observers, which in turn reduced the punitive intentions. These results give support to the assumption that nonverbal shame displays serve a unique social function in preventing moral punishment and social exclusion. However, this support is only partial as the social functions of displaying shame are largely parallel to those of expressing sadness in the situation.
Sensitivity Analysis of Locked Circuits

Globalization of integrated circuits manufacturing has led to increased security concerns, notably theft of intellectual property. In response, logic locking techniques have been developed for protecting designs, but many of these techniques have been shown to be vulnerable to SAT-based attacks. In this paper, we explore the use of Boolean sensitivity to analyze these locked circuits. We show that in typical circuits there is an inverse relationship between input width and sensitivity. We then demonstrate the utility of this relationship for deobfuscating circuits locked with a class of “provably secure” logic locking techniques. We conclude with an example of how to resist this attack, although the resistance is shown to be highly circuit dependent.
CD8+ Tumour-Infiltrating Lymphocytes and Tumour Microenvironment Immune Types as Biomarkers for Immunotherapy in Sinonasal Intestinal-Type Adenocarcinoma

Background. Intestinal-type adenocarcinoma (ITAC) is a rare tumour occurring in the ethmoid sinus. Recent years have brought advances in endoscopic surgery and precision radiotherapy; however, five-year overall survival has not improved and remains at 35–80%, depending on tumour stage and histology. Therefore, there is a need for new therapeutic options. Methods. We evaluated CD8+ tumour-infiltrating lymphocytes (TILs) and tumour microenvironment immune type (TMIT, combining CD8+ TILs and PD-L1) as predictive biomarkers for immunotherapy in a series of 133 ITAC. All results were correlated to clinical and follow-up data. Results. The presence of intratumoural CD8+ TILs was low in 57% of cases and high in 8% of cases. Tumoural PD-L1 positivity was observed in 26% of cases. CD8+ TILs and TMIT correlated with the histological subtype of ITAC and with better overall survival. The presence of stromal PD-L1-positive macrophages was related to intratumoural CD8+ TILs. PD-L1 expression on tumour cells or macrophages did not show prognostic value. Conclusions. TMIT classification did not have additional prognostic value over CD8+ TILs alone. The modest percentage of CD8high/PD-L1pos cases indicates that ITAC is a lowly immunogenic tumour type. Nevertheless, a proportion of ITAC, especially the papillary and colonic subtypes, could benefit from therapy with immune checkpoint inhibitors.
Does Digital Detox Work? Exploring the Role of Digital Detox Applications for Problematic Smartphone Use and Well-Being of Young Adults Using Multigroup Analysis

The constant availability of social networking sites (SNSs) on smartphones has an enormous distracting potential and may lead to problematic usage behavior, especially among younger age groups. In this context, an emerging trend of using so-called digital detox applications (apps; e.g., iOS Screen Time) can be witnessed, which allows users to monitor and limit their smartphone use as well as to consciously disconnect for a certain period of time. However, it remains unclear whether digital detox apps can indeed reduce negative consequences of using SNSs such as problematic smartphone use (PSU) and decreased well-being. Drawing from self-regulation theory, we investigated the relationships between using SNSs, PSU, and well-being among a sample of 500 young adults between 18 and 35 years of age. We used multigroup analysis to compare digital detox app users and nonusers. Results revealed that a high proportion of young adults use digital detox apps (41.7 percent). Among those who did not use such apps, using SNSs was positively associated with PSU, which was negatively related to well-being. Among digital detox app users, we found no such relationship. Thus, digital detox apps seem to be a valuable tool to prevent harmful effects of using SNSs on well-being among young people by reducing the risk of using the smartphone compulsively.
Macrophage Cell-Cell Interactions Promoting HIV-1 Infection

Many pathogens infect macrophages as part of their intracellular life cycle. This is particularly true for viruses, of which HIV-1 is one of the best studied. HIV-1 infection of macrophages has important consequences for viral persistence and pathogenesis, but the mechanisms of macrophage infection remain to be fully elucidated. Despite expressing viral entry receptors, macrophages are inefficiently infected by cell-free HIV-1 virions, whereas direct cell-cell spread is more efficient. Different modes of cell-cell spread have been described, including the uptake by macrophages of infected T cells and the fusion of infected T cells with macrophages, both leading to macrophage infection. Cell-cell spread can also transmit HIV-1 between macrophages and from macrophages to T cells. Here, we describe the current state of the field concerning the cell-cell spread of HIV-1 to and from macrophages, discuss mechanisms, and highlight potential in vivo relevance.
Factors influencing uptake, continuation, and discontinuation of oral PrEP among clients at sex worker and MSM facilities in South Africa

Background South Africa became the first country in Africa to introduce oral PrEP in June 2016. The National Department of Health has used a phased approach to rollout, allowing for a dynamic learn-and-adapt process which will lead ultimately to scale-up. Phased rollout began with provision of oral PrEP at facilities providing services to sex workers in 2016 and was expanded in 2017, first to facilities providing services to MSM and then to students at selected university campus clinics, followed by provision at primary health care facilities. Programmatic data shows variability in initiation and continuation between these populations. This study examines factors related to PrEP initiation, continuation, and discontinuation at facilities providing services to sex workers and MSM during the national PrEP rollout. Methods A cross-sectional survey was administered September 2017-January 2018 among clients (ages 18–62 and providers at 9 facilities implementing oral PrEP in South Africa, followed by in-depth interviews. The client survey captured PrEP initiation, continuation and discontinuation. Analysis was performed in STATA 13 for survey data and thematic analysis was performed in NViVO 11 for in-depth interview data. Results 299 clients (203 from sex worker facilities, 96 from MSM facilities) participated in the survey and additionally, in-depth interviews were conducted with 29 clients. Participants self-identified as either current users (n = 94; 36.2%), past users (n = 80; 30.8%) and never users of PrEP (n = 86; 33.1%). Participants who had never used PrEP either cited not being offered PrEP by a provider (57%, n = 49) or declining PrEP (43%, n = 37) as reasons for lack of uptake. The primary reason for declining to use oral PrEP was fear of side effects (41.7%, n = 15). The primary reasons for initiating and continuing on oral PrEP were all related to perceived risk associated with sexual activity. The majority of participants (87.9%, n = 153) also noted that printed IEC materials influenced their decision to initiate PrEP. Qualitative data suggested that several clients initiated on PrEP because they wanted additional protection beyond using condoms due to challenges such as partners refusing to use condoms, having partners with unknown HIV status, having multiple partners, involvement in sex work, or having a partner living with HIV. The majority (73.8%, n = 59) of participants who discontinued oral PrEP cited side effects as the primary reason for discontinuation, followed by feeling stigmatized (18.8%, n = 15). Conclusion This study provides valuable insights on early rollout of PrEP of how clients perceive oral PrEP and where to target efforts to improve the uptake of this highly effective HIV prevention product. By identifying strengths and areas for improvement, the ACCESS study has generated evidence that can be used to guide high quality scale-up in South Africa and may be instructive for other countries’ efforts to expand quality access to oral PrEP.
Reproductive cycles and fecundities of two species of siphonaria (Mollusca: Pulmonata) in South-Eastern Australia

The reproductive cycles of Siphonaria denticulata and S. virgulata were determined by measuring the length or weight of the spawn of each species. S. denticulara lays a typical. coiled, gelatinous egg ribbon, cemented to the rocky substratum. S. virgulata lays a globular egg mass which is released directly into the water. This latter form of spawning is apparently unique amongst pulmonate molluscs. S. denticulata has a long breeding season, extending from November-December to the following April-May. Spawning usually occurs every 2 weeks for large adults, but smaller (i.e. younger) limpets spawn less frequently. Periods of spawning correspond to periods of full or new moons. The exact length of the breeding season of S. virgulata is unknown. Estimates of fecundity were obtained from counts of eggs within egg masses. There were differences in the fecundity of S. denticulata between localities, but S. denticulata and S. virgulata from the same locality had similar fecundities for similar-sized animals. Egg ribbons of S. denticulata experimentally placed high on the shore were found to suffer higher mortality from desiccation than those lower on the shore. This may explain why S. virgulata, which generally lives higher on the shore than its congener, has pelagic egg masses.
The Long-Term Reoperation Rate Following Surgery for Lumbar Stenosis: A Nationwide Sample Cohort Study with a 10-Year Follow-Up.

STUDY DESIGN Retrospective cohort study of a nationwide sample database. OBJECTIVE The objective of the present study was to compare the long-term incidence of reoperation for lumbar spinal stenosis (LSS) after anterior fusion, posterior fusion, and decompression. SUMMARY OF BACKGROUND DATA Surgical treatment for LSS can be largely divided into two categories: decompression only and decompression with fusion. A previous nationwide study reported that fusion surgery was performed in 10% of patients with LSS, and the 10-year reoperation rate was approximately 17%. However, with the development of surgical techniques and changes in surgical trends, these results should be reassessed. METHODS The National Health Insurance Service-National Sample Cohort of the Republic of Korea was utilized to establish a cohort of adult patients (N = 1,400) who first underwent surgery for LSS during 2005-2007. Patients were followed for 8-10 years. Considering death before reoperation as a competing event, reoperation hazards were compared among surgical techniques using a Fine and Gray regression model after adjustment for sex, age, diabetes, osteoporosis, Charlson comorbidity index, severity of disability, type of medical coverage, and type of hospital. RESULTS The overall cumulative incidence of reoperation was 6.2% at 2 years, 10.8% at 5 years and 18.4% at 10 years. The cumulative incidence of reoperation was 20.6%, 12.6% and 18.6% after anterior fusion, posterior fusion, and decompression, respectively, at 10 years postoperatively (p = 0.44). The first surgical technique did not affect the reoperation type (p = 0.27). Decompression was selected as the surgical technique for reoperation in 83.5% of patients after decompression, in 72.7% of patients after anterior fusion, and in 64.3% of patients after posterior fusion. CONCLUSION The initial surgical technique did not affect reoperation during the 10-year follow-up period. Decompression was the most commonly used technique for reoperation. LEVEL OF EVIDENCE 4.