Miracle-dz/UniFAR-FTUs huggingface dataset:
The specific delivery of radloisotopes to a tumor at minimal radiation of normal tissue is the ultimate aim of radioimmunetherapy. In this

The specific delivery of radloisotopes to a tumor at minimal radiation of normal tissue is the ultimate aim of radioimmunetherapy. In this reaped a two-step pretargeting regimen generally leads to an improved tumor to normal tissue uptake ratio compared to direct administration of radiohnmunoconjugates. In this paper, in vitro studies are described in which the specific hybridization of complementary DNA fragments is the recognition mechanism in a pretargeting regimen comprising tumor cell saturation with a monoclonal antibody (MoAb)-ollgonucleotide conjugate, followed by administration of the radiolabeled complementary oligo nucleotlde Complementary oligodeoxynucleotides (15-mers; melting temperature, 680C) were prepared on a DNA synthesizer. The 5'-end was derivatized with a functional group for labeling with iodine, and the 3'-end was substituted with an amino function suitable for conjugation to an antibody (or attachment of a biotin residue). Both terminal modifications ensure stabifity of the oligonucleotides against exonucleases because the uncon jugated form is stable for 24 h and the conjugated form is stable for several days when incubated in human plasma at 37Â°C.Antibody-DNA conjugates were prepared by Introduction of sulihydryl groups into the oligonucleotide, followed by conjugation to maleimide-subofituted MoAbs Typically, 3 oligonucleotides were conjugated to an IgG, and 4-6 were conjugated to an 1gM with preservation of immunoreactivity. Histochemistry on fresh frozen sections of breast cancer tissue demon strated qualitatively the specificity of our two-step procedure. In vitro experiments with human tumor cell lines and tumor-specific MoAbs showed that, after saturation with tumor-specific MoAb-DNA conjugates, quantitative hybridization of the tumor cell-bound oligonucleotides oc curred at a 30-fold excess of the labeled complementary oligonucleotide: hybridization was complete after 30 mm of Incubation. No reaction was observed with an Irrelevant MoAb-DNA conjugate. The oligonucleotide was neither taken up by tumor cells or endothellal cells nor hybridized to a significant extent with human genomic DNA. These data indicate the feasibility of this two-step approach in radio immunotherapy.
Methodologies for evaluating survey questions: some lessons from the redesign of the Current Population Survey.

Various techniques have been developed over the years to pretest new survey questions or to evaluate the effectiveness of existing questions. As part of the current effort to redesign the Current Population Survey (CPS) researchers from Census and BLS are using a variety of methods to evaluate questions designed to elicit accurate labor force data and to assess the quality of interviewer-respondent interactions. These methods include: a) the coding of interviewer and respondent behavior b) debriefing respondents to obtain additional information about how they view CPS questions/concepts c) debriefing interviewers on how respondents react to and understand CPS questions/concepts and d) comparing item nonresponse rates and response distributions for different versions of the same survey questions. This paper describes the advantages and disadvantages of each of these techniques. The discussion is illustrated with selected results from a CATI/RDD field test. (authors)
FACTORS THAT INFLUENCING CAPITAL EXPENDITURE: PERSPECTIVE PECKING ORDER AND MANAGERIAL HYPOTHESES

The objectives of this study are to observe the impact of internal cash flow, insider ownership, investment opportunity, investment opportunity and firm size on the capital expenditure in two different theories. Those theories are: (1) the pecking order hypotheses and (2) the managerial hypotheses, tested in Indonesian case. The pecking order hypotheses postulates that managers can choose the level of capital expenditure to maximize the wealth of current shareholders without considering insider ownership in the company. On the other hand, according to the managerial hypotheses, managers whose ownership proportions are small tend to use higher level of internal cash flows to finance the capital. The data of this study is collected from 11 manufacture companies as listed in the Indonesian Stock Exchange. The result of this study shows that the internal cash flow, insider ownership, firm size and investment opportunity have positive impact on the capital expenditure. However, the impact of insider ownership and investment opportunity on the capital expenditure are not significant. Eventually, this study is appropriate with the pecking order hypotheses.
Subjective Evaluation In Engineering Design

Engineering students may not receive sufficient experience and help in making and understanding subjective decisions. Two studies are presented that imply engineering students have poor subjective evaluation skills. The artifacts resulting from two design studies were evaluated by two different classes of sophomore engineering students and their instructor. One study represented innovative design, and the artifact was designed and fabricated by teams composed of four students each. The other study represented routine design and was addressed by individual students working alone. Both the instructor and students, acting individually, evaluated both the team and individually produced design artifacts. Compared with the instructor’s evaluations of the artifacts, the students undervalued the best artifacts and greatly overvalued the worst artifacts. Most demonstrated very little discrimination in their evaluations. However, the better designers were also better “graders” in that their evaluations more closely followed those of the instructor. Self-evaluations followed the same trends with many of the poorest designers grossly overvaluing their own artifacts. The results indicated that designing ability correlates positively with critical evaluation skills, and it is proposed that the teaching of such skills should be included in design courses.
University of Birmingham Performance improvement of ballasted railway tracks using geocells

The dramatic increase in the axle load and speed of the rolling stock over the recent years has challenged the stability and performance of the railway tracks. Consequently, rail track designers and engineers are exploring suitable measures to improve the performance of the tracks. The geocells can offer a cost-effective and feasible solution for enhancing the performance of the railway tracks. The satisfactory performance of geocells in numerous geotechnical applications such as reinforced retaining walls, slopes, embankments, pavements, etc. have encouraged their use in other areas too. However, their utilization in the railway tracks is still in the nascent stage. Thus, the present chapter examines the potential benefits of using geocells in the railway tracks. The results of the numerous experimental, numerical and field studies have been briefly reviewed. The influence of geocell reinforcement on the parameters (or material properties) essential for the track stability have been discussed. The past studies indicate that the geocells can be effectively used to improve the performance of the railway tracks. The geocells provides confinement which increases the strength and stiffness of the infill materials. Moreover, the geocell reinforcement significantly decreases the lateral deformation and permanent settlement of the granular materials. However, the amount of improvement significantly depends on the properties of the geocell, infill, subgrade and the location of the geocell reinforced layer.
KNOWLEDGE MANAGEMENT INSIDE OF A SMALL ORGANIZATION

Knowledge Management is wide and unclear concept of creating, sharing and applying knowledge inside and outside of organization. Strategic and systematic use of this approach can have beneficial outcome on organizational progressing. Thus, knowledge management appears to be the new main assets when it comes to organizational effectiveness. This work aims to create a valuable insight into knowledge flow insight of the small organization and its effect on their growth. For this purpose, we define Knowledge Management, introduce it inside of a small organization and apply the most effective model of knowledge sharing into that organization. The right model will be chosen after creating and analyzing right survey composed out of 21 questions related to the topic. Finding the right model for knowledge obtained inside of organization presents a great challenge for leaders. In this dissertation, we analyze the best solutions and strategies that could upgrade organizational growth, along with providing new knowledge creating and sharing models but at the same time preventing knowledge loss.
Preparation of Sulphide-lime Unhairing Ratios for Pollution Load Reduction in the Manufacture of Shoe Upper Leathers from Tropical Goat Skins

Preparation of sulphide-lime unhairing tannery process was carried out using nine ratios coded as A I – A III ; B I - B III and C I – C III with varied concentrations of sodium sulphide and hydrated lime. Result obtained through subjective tests and gravimetric method show differences in degree of unhairing, swelling and plumping of the pelts. The pH of wastewater generated from each ratio and weight increase of limed pelts, was observed and recorded. Analysis of pollutants from the wastewater was determined by parameters such as BOD, COD, and Sulphide generated from the wastewater. Results obtained show various levels of parameters from the studied ratios indicated that A-group had poor unhairing and liming properties. The C-group gave excellent properties but with higher pollution load. However, B II (2.5% Na 2 S with 2.0% Ca(OH) 2 ) and B III (2.8% Na 2 S with 2.5% Ca(OH) 2 ) in 200% float generated lower pollution level as determined by the parameters from their individual wastewaters. This was compared with the conventional (CTL) and that of the industry. The average sample wastewater collected from the industry indicated higher pollutants than the studied and CTL ratios. The study reveals that maximum utilization of reagents is a necessary technique for reduction of pollutants in the wastewater from sulphide-lime unhairing process known to generate 65%-70% of pollutants from the beam-house.
Interferon y response region in the promoter of the human DPA gene

The interferon y (IFN-y) response region of the human class II major histocompatibility complex gene, DPA, has been localized to a 52-base-pair (bp) DNA fragment in the proximal promotor at -107 to -55 bp after transfection into HeLa cells of a series of 5', 3', and gap deletion mutants linked to a reporter gene, human growth hormone, as well as of synthetic oligonucleotides fused to the heterologous promoter thymidine kinase. The 52-mer sequence contains the X and Y box elements conserved in all class II genes; their presence is indispensable for IFN-y inducibility. Furthermore, an additional 5 bp immediately 5' of the X box of the DPA gene are necessary and sufficient for IFN-y induction. This region may contain an IFN-y response element. A closely related sequence has also been found in the vicinity of the critical deletion sites of three other well-studied class II gene promoters, all of which require a much longer sequence 5' of the X box. A fourth element, the W element, located about 15 bp 5' of the X box in all class II genes, is clearly of little importance in IFN-y inducibility of the DPA gene.
Expression of MUC1 & MUC2 in Colorectal Adenocarcinoma

Background: Throughout the world colorectal cancer is a major cause of morbidity and mortality. It is the most common cancer and the fourth most frequent cause of cancer death worldwide. The annual incidence rates (AARs) for colon cancer and rectal cancer in India in men are 4.4 and 4.1 per 100000, respectively. MUC1 is normally expressed on the apical borders of various glandular and luminal epithelial cells. MUC1 represents the best characterized membrane-associated mucin. The expression of MUC1 is up-regulated in colorectal cancer. MUC2 is expressed by intestinal goblet cells. The expression of MUC2 is down-regulated in non-mucinous adenocarcinomas arising within adenomas. Methods: A descriptive and cross-sectional study was conducted in Department of Pathology, Himalayan Institute of Medical Sciences, Swami Ram Nagar, Dehradun, on 30 surgical specimens and biopsies of colorectal adenocarcinoma after signed informed consent of patients. Immunohistochemical expression of MUC1 and MUC2 were studied. Results: Maximum numbers of the cases were in fifth decade with male to female ratio of 0.8:1. The most common presenting complaint among the cases of CRC was pain in abdomen (n=26; 86.66%) followed by rectal bleeding (n=18; 60%), constipation (n=11; 36.66%) and weight loss (n=10 ; 33.33%). Maximum number of CRC cases (60%) was in T3N0 TNM stage. Over expression of both MUC1 and MUC2 was observed in 50% of the cases. Over 30% of the cases expressed only MUC1 while 13.3% of the cases expressed only MUC2. Conclusion: Expression of MUC1 was more than MUC2 in CRC cases. Although data obtained in the present study on prognostic importance of MUC1 and MUC2 is not statistically significant, yet both MUC1 & MUC2 were over expressed in CRC.
yV-Hydroxy-2-acetylaminofluorene Sulfotransferase: Its Probable Role in Carcinogenesis and in Protein-(methion-S-yl) Binding in Rat Liver1

SUMMARY 1- and (1-and were identified as degra dation products of hepatic protein-bound methionyl de rivatives in rats given AAF or Â¿V-hydroxy-AAF.The same derivatives were shown previously to be products of the in vitro reaction of free or peptide-bound methionine with various synthetic esters of N-hydroxy-AAF, in cluding the very reactive 0-sulfonate (AAF-yV-sulfate). The amounts of o-methylmercapto-AAF obtained from liver protein were proportional to the dose of 7V-hydroxy-AAF given i.p. and appear to be a measure of the amount of ester-like metabolites of the carcinogen formed in vivo. and 3-Methylmercapto-2-aminofluorene were not ob tained as degradation products of the liver proteins of rats or other animals given or of rats given
Influence of benzyl adenine and gibberellic acid on morphological behaviour of Asiatic lily

An experiment on “Influence of benzyl adenine and gibberellic acid on morphological behaviour of Asiatic lily” was conducted at experimental block (protected condition) in the Department of Floriculture and Landscape Architecture, College of Horticulture, Mudigere (under University of Agricultural and Horticultural Sciences, Shivamogga), during 2019-2020. The experiment comprises of 16 treatments alone and in combinations of benzyl adenine (50, 100 and 150 ppm), gibberellic acid (100,150 and 200 ppm) and control (water soaking) replicated thrice in Randomized Complete Block Design (RCBD). The GA 3 @ 200 ppm exhibited earlier sprouting (6.00 days), maximum sprouting per cent (99.03), plant height (83.13 cm), number of leaves (67.25), leaf length (10.27 cm), leaf breadth (2.51 cm), leaf area (1139.00 cm 2 ) and leaf area index (3.80). The Basal stem diameter (18.06 mm), chlorophyll-a (1.31 mg/g), chlorophyll-b (0.36 mg/g) and total chlorophyll (1.94 mg/g) recorded maximum in BA @ 150 ppm. While maximum days taken for bulb sprouting (12.12), minimum plant height (36.72 cm), number of leaves (29.33), leaf length (7.11 cm), leaf area (518.33 cm 2 ) and leaf area index (1.71) recorded in the BA @ 150 ppm.
Empirical Research of Work-family Conflict in China

为了解处于社会转型期的我国员工的工作-家庭冲突状况及原因,作者采用问卷法对448名文教卫生系统的员工进行了调查. 结果表明:工作家庭冲突比家庭工作冲突严重;影响工作家庭冲突的因素包括工作时间、加班与轮班、工作卷入、来自单位的支持和照顾老幼等,多数与工作有关,而影响家庭工作冲突的因素则包括家庭卷入、来自家庭的支持和工作时间,主要与家庭有关;社会支持有助于缓解工作-家庭冲突.
Burnout among teachers in private institutions of higher education

The occupational health of teachers is an important theme in international and national literature. In Brazil, there is a lack of studies on Burnout in university teachers of the private school system. Thus, the purpose of this study is to assess the influence of Perceived Organizational and Social Support at work as well as socio-demographic variables over the incidence of Burnout in this public. The participants were 173 teachers who voluntarily answered valid and reliable questionnaires in their work environment. Data analyzed has used described statistics and standard multiple regression analysis. The results indicated symptoms of Burnout syndrome in teachers as well as greater predictive power of organizational support in the occurrence of the syndrome. Emotional social support, working time in the institution, age, and workload were predictors, but with less emphasis. Studies have recommended in samples from other regions of the country as well as longitudinal studies.
Recent Results from Reactor Antineutrino Experiments

The smallest neutrino mixing angle θ 13 has been successfully measured by the disappearance of reactor antineutrinos at RENO, Daya Bay, and Double Chooz. The oscillation frequency is also measured based on energy and baseline dependent disappearance probability of reactor antineutrinos. Recent results ﬁnd a variation in the observed reactor antineutrino ﬂux as a function of the reactor fuel evolution. We report more precisely measured values of θ 13 and ∆ m 2 ee and results on the evolution of observed reactor antineutrino yield and spectrum.
Cloning and Expression of a Potato cDNA Encoding Hydroxycinnamoyl-CoA:Tyramine N -(Hydroxycinnamoyl)transferase*

Hydroxycinnamoyl-CoA:tyramine N -(hydroxycin-namoyl)transferase (THT; EC 2.3.1.110) catalyzes the transfer of hydroxycinnamic acids from the respective CoA esters to tyramine and other amines in the formation of N -(hydroxycinnamoyl)amines. Expression of THT is induced by Phytophthora infestans , the causa-tive agent of late blight disease in potato. The amino acid sequences of nine endopeptidase LysC-liberated peptides from purified potato THT were determined. Using degenerate primers, a THT-specific fragment was obtained by reverse transcription-polymerase chain reaction, and THT cDNA clones were isolated from a library constructed from RNA of elicitor-treated potato cells. The open reading frame encoding a protein of 248 amino acids was expressed in Escherichia coli . Recombinant THT exhibited a broad substrate specificity, similar to that of native potato THT, accepting cinnamoyl-, 4-coumaroyl-, caffeoyl-, feruloyl- and sinapoyl-CoA as acyl donors Purification and characterization of THT was achieved with potato (23, 24) and tobacco (22) sus-pension-cultured cells. In continuation of our studies on the induction of the phenylpropanoid metabolism in potato by P. infestans , we report here partial amino acid sequencing of THT as well as molecular cloning and prokaryotic expression of a
Pore-scale numerical simulation of supercritical CO2 migration in porous and fractured media saturated with water

1State Key Laboratory of Geomechanics and Geotechnical Engineering, Institute of Rock and Soil Mechanics, Chinese Academy of Sciences, Wuhan 430071, P. R. China 2University of Chinese Academy of Sciences, Beijing 100049, P. R. China 3Institute of Architectural Engineering, Sichuan Institute of Industrial Technology, Deyang 618209, P. R. China 4Energie-Forschungszentrum Niedersachsen, Clausthal University of Technology, Goslar 38640, Germany 5State Key Laboratory of Hydraulic and Mountain River Engineering, Sichuan University, Chengdu 610065, P. R. China 6Key Laboratory of Deep Earth Science and Engineering, Ministry of Education, Sichuan University, Chengdu 610065, P. R. China
A RESEARCH ON DETERMINING THE RELATIONSHIP BETWEEN CONSUMERS’ PURCHASING STYLES AND THEIR RELIGIOUS ORIENTATIONS

This study was conducted in Isparta and Burdur sample cities to determine the relationship between consumers’ purchasing styles and their religious orientations. The data were analyzed by using statistical tests including “Reliability,” “Factor Analysis,” and “Correlation Analysis” with the SPSS 20 package program. The nine factors that emerged from factor analysis of items related to consumers’ purchasing styles were named as “Brand Conscious”, “Perfectionist,” “Confused,” “Fashion Conscious,” “Pleasure Conscious,” “Brand Loyalty,” “Unplanned,” “Careful” and “Innovative. ” The four factors that emerged from factor analysis of items related to religious orientations of consumers were named as “Intrinsic Religious Orientation,” “Religious Interest,” “Religion and Prayer,” and “Liberalism. ” In the study, a positive, significant, and very weak relationship was observed between participants’ purchasing styles and their religious orientation dimensions. Relations between Perfectionist, Brand Loyalty, and Careful which are Purchasing Style dimensions, and Intrinsic Religious Orientation and Religion and Prayer, which are religious orientation dimensions, were similar.
Anna von Rettig Masteruppsats

Computer Assisted Translation tools continue to become more ubiquitous, but translation students do not necessarily receive much training in using them, and may therefore find translating when using them very different to translating freehand. An experiment was conducted where a three Master’s students were each asked to translate two texts; one in a CAT tool and the other freehand, and the resulting target texts were inspected to determine whether they may have been affected by the segmentation performed by the CAT tool compared to freehand translations of the same text, and if so, how. There were indications that in certain cases, such as very long sentences, the CAT tool may act as a visual aid, and also indications that certain students may be more prone to follow the segmentation provided by the CAT tool than others. However, the influence of personal translator style and translator’s habitus cannot be disregarded and as such the differences that are apparent cannot be entirely attributed to the CAT tool.
ARTIFICIAL NEURAL NETWORKS APPLIED FOR SOIL CLASS PREDICTION IN MOUNTAINOUS LANDSCAPE OF THE SERRA

Calderano Filho, Braz; Polivanov, Helena; da Silva Chagas, César; de Carvalho Júnior, Waldir; Velloso Barroso, Emílio; Teixeira Guerra, Antônio José; Barreiros Calderano, Sebastião ARTIFICIAL NEURAL NETWORKS APPLIED FOR SOIL CLASS PREDICTION IN MOUNTAINOUS LANDSCAPE OF THE SERRA DO MAR Revista Brasileira de Ciência do Solo, vol. 38, núm. 6, noviembre-diciembre, 2014, pp. 1681-1693 Sociedade Brasileira de Ciência do Solo Viçosa, Brasil
Near-orthogonal Orientation of Small-scale Magnetic Flux Ropes Relative to the Background Interplanetary Magnetic Field

Small-scale magnetic flux ropes (SMFRs) have been identified at a large range of heliospheric distances from the Sun. Their features are somewhat similar to those of larger-scale flux rope structures such as magnetic clouds (MCs), while their occurrence rate is far higher. In this work, we examined the orientations of a large number of SMFRs that were identified at 1 au by fitting to the force-free model. We find that, while most of the SMFRs lie mostly close to the ecliptic plane, as previously known, their azimuthal orientations relative to the Sun–Earth line are found largely at two specific angles (slightly less than 45° and 225°). This latter feature in turn leads to a strong statistical trend in which the axis of SMFRs lies at a large tilt angle relative to (most often nearly orthogonal to) the corresponding background interplanetary magnetic field directions in the ecliptic plane. This feature is different from previous reports on SMFRs—and in stark contrast to the cases of MCs. This is an important observational constraint that should be considered for understanding SMFR generation and propagation.