Miracle-dz/UniFAR-FTUs huggingface dataset:
Arcuate Angiotensin II Increases Arterial Pressure via Coordinated Increases in Sympathetic Nerve Activity and Vasopressin Secretion

Visual Abstract The arcuate nucleus (ArcN) is an integrative hub for the regulation of energy balance, reproduction, and arterial pressure (AP), all of which are influenced by Angiotensin II (AngII); however, the cellular mechanisms and downstream neurocircuitry are unclear. Here, we show that ArcN AngII increases AP in female rats via two phases, both of which are mediated via activation of AngII type 1 receptors (AT1aRs): initial vasopressin-induced vasoconstriction, followed by slowly developing increases in sympathetic nerve activity (SNA) and heart rate (HR). In male rats, ArcN AngII evoked a similarly slow increase in SNA, but the initial pressor response was variable. In females, the effects of ArcN AngII varied during the estrous cycle, with significant increases in SNA, HR, and AP occurring during diestrus and estrus, but only increased AP during proestrus. Pregnancy markedly increased the expression of AT1aR in the ArcN with parallel substantial AngII-induced increases in SNA and MAP. In both sexes, the sympathoexcitation relied on suppression of tonic ArcN sympathoinhibitory neuropeptide Y (NPY) inputs, and activation of proopiomelanocortin (POMC) projections, to the paraventricular nucleus (PVN). Few or no NPY or POMC neurons expressed the AT1aR, suggesting that AngII increases AP and SNA at least in part indirectly via local interneurons, which express tyrosine hydroxylase (TH) and VGat (i.e., GABAergic). ArcN TH neurons release GABA locally, and central AT1aR and TH neurons mediate stress responses; therefore, we propose that TH AT1aR neurons are well situated to locally coordinate the regulation of multiple modalities within the ArcN in response to stress.
Somatic comorbidities of inpatients receiving treatment for alcohol withdrawal syndrome on a psychiatric ward and their relation to delirium tremens

Purpose This study aimed to assess the influence of somatic diseases and patient characteristics (age, gender) in relation to delirium tremens (DT) episodes in alcohol withdrawal syndrome (AWS). We also analysed the influence of age, gender and specific somatic diseases on the duration of hospital stay and the frequency of comorbid somatic diseases among AWS and DT patients. Methods The medical records of patients admitted to an AWS treatment ward in a Polish psychiatric hospital in 2019 were analysed. In total, 800 hospitalisations of 656 patients (625 hospitalisations for AWS and 175 for DT) were evaluated. Results The most frequent group of somatic diseases among AWS and DT patients was cardiovascular diseases, with essential hyper tension as the main medical condition. Patients suffering from DT were diagnosed with respiratory system diseases (p < 0.001) and pneumonia (p < 0.000) more often than AWS patients. Hospital stays were longer for patients with pneumonia, chronic obstructive pulmonary disease and duodenal ulcers. Patients with acute pancreatitis were hospitalised for a significantly shorter period of time than other patients. Patient gender and age did not significantly affect the development of DT. However, age was positively correlated with duration of hospitalisation (p < 0.001). Conclusions The presence of respiratory system diseases, especially pneumonia, was found to influence the incidence of DT in AWS patients. Increased clinical vigilance for the prevention of lower airway infections in AWS patients is essential.
Dynamic harmonic evolution using the extended harmonic domain

A novel methodology is presented in this paper for conducting transient and steady-state analysis of electric networks containing nonlinearities and switching plants components. The method is termed the extended harmonic domain (EHD) method as may be seen as an extension of the harmonic domain (HD) method used in steady-state analysis. It is shown in the paper that EHD is a natural approach for conducting dynamic and steady-state studies of the evolution of harmonics in power circuits containing nonlinear components and flexible AC transmission systems (FACTS) devices. It is also shown in the paper that EHD provides a suitable basis for extending the well-known steady-state power quality indices to the transient range. To illustrate the use of the theory, a three-phase linear circuit and a three-phase PWM-STATCOM are modeled using EHD. The results are compared against those provided by industry standard tools as PSCAD/EMTDC and Matlab.
Selenium Enriched Peanut Protein Alleviates Alcohol-Induced Liver Damage in Mice by Modulating the Composition of the Gut Microbiota

Corresponding Author: Jihong Wu China Agricultural University, No. 17, Qinghua East Road, Haidian District, Beijing 100083, China. E-mail: wjhcau@hotmail.com Abstract: Alcohol Use Disorder (AUD) is one of leading external causes of mortality. Selenium-enriched Peanut Protein (SePP) is a type of Se compound present in Se-enriched plants. Our previous studies showed that SePP possesses potential therapeutic properties and could alleviate alcoholinduced AML-12 cytotoxicity. It spurred us to determine the underlying mechanisms and roles of SePP on gut microbiota. Here, ICR mice were fed either standard diet or ethanol (30%, v/v, 10 mL/kg bw/day) intragastric administration for 8 weeks. The intervention groups were divided into different doses of SePP groups and Se compounds groups, like Selenomethionine (SeMet) group, sodium selenite group. The composition of the gut microbiota was investigated by analyzing 16S rRNA gene sequences. Body weight, lipid metabolism markers, serum insulin and oxidative stress were assessed. Treatment with SePP at a certain dosage (25 μg/kg bw/day in Se) and SeMet reversed diversity loss and community alterations in the gut microbiota of the AUD group, as evidenced by an increased abundance of Firmicutes and decreased abundances of Bacteroidetes and Verrucomicrobia in AUD mice. SePP suppressed the relative abundance of the Rikenellaceae_RC9 gut group and increased those of Lachnospiraceae and Ruminococcaceae, which are associated with lipid metabolism and Short-Chain Fatty Acids (SCFAs) production. The study suggested that SePP has the potential to be used as a supplement for alleviating alcohol-induced liver damage.
Do Hostile Media Perceptions Constrain Minipublics? A Study of How Oregon Voters Perceive Citizens' Statements

The deliberative quality of a minipublic often depends on its ability to inform the opinions of a larger public. The Citizens’ Initiative Review (CIR) aims to do so by producing a Citizens’ Statement, which we conceptualize as a deliberative form of mass media. Like any mass media, this Statement can only influence public opinion to the extent that citizens consider it unbiased and credible. Hostile media perceptions often prevent favorable evaluations of media content, but no prior work has considered whether these perceptions could undermine the output of deliberative minipublics. To examine that possibility, we analyze online survey data on Oregon voters’ assessments of two 2014 Citizens’ Statements. Results showed that voters’ evaluations of the Statements were unaffected by hostile media perceptions. Assessments were more favorable when voters had confidence in their knowledge of the CIR’s design, process, and participants. Evaluations also were more favorable for those voters with greater faith in deliberation’s capacity to render considered judgments. We elaborate on these findings in our discussion section and consider their theoretical and practical implications for implementing minipublics and bolstering their deliberative quality.
BREADS FROM WHITE GRAIN SORGHUM: RHEOLOGICAL PROPERTIES AND BAKING VOLUME WITH EXOGENOUS GLUTEN PROTEIN

Bread made with a composite flour containing sorghum is nutritionally valuable. However, sorghum alone lacks the functional proteins for breadmaking. This study investigated the rheological properties and bread baking potential of a sorghum-based composite flour system containing various amounts of vital wheat gluten (exogenous gluten protein). Mixograph and Kieffer tests result showed that exogenous gluten protein significantly enhanced the composite dough’s strength. At fixed gluten protein levels, as sorghum flour increased, water absorption decreased slightly, dough strength and extensibility decreased, and mixing time increased significantly. Exogenous gluten proteins when added in the form of vital wheat gluten into the composite flour without wheat flour could not form an appropriate gluten network for bread making. The interaction between exogenous and endogenous proteins in wheat flour and in the composite flour contributed greatly to the rheological properties of the sorghum composite dough and bread volume.
The effects of general and firm-specific training on wages and performance: evidence from banking

By using new panel data for Finnish banks we study the impact of training on wages and performance. To the best of our knowledge, ours is the first paper to compare explicitly the effects of general and firmspecific workplace training on outcomes for both employees and firms. Unlike much existing literature, we find stronger evidence that training improves worker outcomes rather than organizational performance. Depending upon specification, the estimated wage elasticity with respect to training is in the range of 3-7%, whereas the performance effects vary widely depending on the measures of training intensity. The other key finding is that general training is associated with higher wage and performance effects than is firm-specific training. YLEISEN JA YRITYSKOHTAISEN KOULUTUKSEN VAIKUTUKSET PALKKOIHIN JA MENESTYMISEEN : Nayttoa pankkitoimialalta
Temporal Forecast Uncertainty for Ramp Events

As the penetration of wind energy continues to increase around the world, the impact of wind energy on the management of electrical grids is becoming increasingly evident. The challenge for the grid operator of integrating wind energy, or for the energy trader to maximise the market value of the energy, is toughest during periods of rapid change in wind farm production, or ramp events. These events are also tough to forecast accurately, and it is therefore essential to understand the uncertainty of forecasting such events. To date the majority of work on the uncertainty of wind energy forecasts has been focused on the possible amplitude of wind production that might occur at a given time. However, there has been limited investigation into effectively defining the possible timing of significant wind energy events. This paper aims to focus on methodologies for generating temporal forecast uncertainty for rapid changes in wind farm production. The first challenge is to define ramp events, secondly the forecast uncertainty needs to be calculated and finally this information needs to be presented clearly to the end user. This paper covers these three areas, with a focus on the method of calculating forecast uncertainty using multiple NWP inputs, statistical processing and adaptive algorithms. The results are based on GH Forecaster services for both individual and portfolios of wind farms. The outcome of the investigation demonstrates that temporal forecast uncertainty can be calculated and clearly presented to indicate the likely timing and amplitude of wind energy ramp events.
A Computational Geometry for the Blades and Internal Flow Channels of Centrifugal Compressors

A new computational geometry for the blades and flow passages of centrifugal compressors is described and examples of its use in the design of industrial compressors are given. The method makes use of Bernstein-Bezier polynomial patches to define the geometrical shape of the flow channels. This has the following main advantages: the surfaces are defined by analytic functions which allow systematic and controlled variation of the shape and give continuous derivatives up to any required order: and the parametric form of the equations allows the blade and channel coordinates to be very simply obtained at any number of points and in any suitable distribution for use in subsequent aerodynamic and stress calculations and for manufacture. The method is particularly suitable for incorporation into a computer-aided design procedure.
Development of Cost Equations for Gac Treatment Systems

The use of granular activated carbon (GAC) as a broad spectrum adsorbant in the treatment of drinking water has been shown to be effective in removing or reducing concentrations of specific organics and total organic carbon (TOC). Much concern has been expressed, however, regarding the cost of GAC systems, and therefore several studies have been conducted to develop cost‐estimating equations for system components. Early cost studies are based on design and not on “as‐built” plants. A comparison between costs from some recently completed field projects and costs estimated from these conceptual design studies has resulted in a reevaluation of the early estimates. Most estimates are close to the actual costs derived from the field projects. However, by combining data from the field projects and design studies, an updated set of cost estimating equations has been developed for GAC treatment systems. These new equations can be used to estimate capital costs and individual operation and maintenance cost components.
Charging of insulating spheres on the surface of an electrode affected by monopolar ions

The charge acquired by an insulating sphere in a uniform monoionized electric field has been accurately evaluated by Pauthenier. In certain electrostatic applications, such as the electroseparation of mixed granular solids, the particles to be charged are on the surface of an electrode. Under these circumstances, Pauthenier's formula is no longer valid, because the field is nonuniform. This paper addresses this problem from both a computational and an experimental point of view. A numerical method of field analysis was employed for the evaluation of the charge acquired by spheres of various dielectric constants, on the surface of a plate electrode. The numerically computed values of the saturation charge in this situation were always greater than those given by Pauthenier's formula. The experiments were carried out on laboratory equipment provided with various types of corona electrodes. An electrometer was used to measure the charge acquired by calibrated spheres of polyamide (3 mm diameter) when subjected to the positive or negative corona discharge generated between these electrodes and a metallic rotating roll electrode (150 mm diameter) connected to the ground. The experimental data were in good agreement with the theoretical predictions; the saturation charge increases linearly with the applied voltage, up to a threshold at which the self discharge of the particle occurs. The efficiency of ionic charging was shown to depend on the type of corona electrode that is employed.
Open archaeology. Advances and challenges in the management of archaeological contents

During the last two decades there has been a crucial change in the ways of producing, accessing and using information from all branches of knowledge, including archaeology. Concepts such as open data and content, open access, free software, social construction of knowledge, etc. have been installed in the theory and practice of scientific research (open science) and administrative management (open government) to become an outstanding potential vector for the advancement of scientific knowledge, the economy based on use of data and the transparency of institutions. In the field of cultural heritage, the democratization of knowledge, social participation in public management or the rise of cultural tourism, also affect the increasingly close relationship between the academic, professional and administrative fields and these, in turn, with a population that ceases to be exclusively passive recipient of the information filtered from these areas, to become involved in many of the aspects that concern its management. In this context, archaeology shows some singularities that will be discussed in this paper, focusing on the Spanish case. For this purpose, the advances that have taken place in the generation of open archaeological contents will be reviewed, as well as the main remaining challenges.
In situ cure monitoring of epoxy resins using optical fibre sensors

This paper describes a comparative study of in situ cure monitoring by three methods: (i) evanescent wave spectroscopy; (ii) refractive index change; and (iii) near-infrared spectroscopy. The cure characteristics of an epoxy/amine reaction were followed in real-time during the crosslinking reaction via the above-mentioned techniques. The evanescent wave spectroscopy technique was based on monitoring the characteristic infrared absorption bands of the resin system to compute the concentration of the amine hardener as a function of cure time. Good correlation was obtained between the evanescent wave spectroscopy data and a conventional method of studying cure reactions, i.e. infrared spectroscopy. During the cure reaction, the refractive index of the resin system increases as a function of the crosslink density. This increase in the refractive index was monitored using two optical fibre techniques. In the first case, a declad region of the optical fibre was immersed in the resin system and in the second method an optical fibre reflectometer was used to track the changes in the refractive index. Once again, good correlation was obtained between the optical fibre techniques and infrared spectroscopy cure data. The results obtained from the optical fibre sensor experiments were used to model the cure kinetics of the resin system. The cure kinetic models were found to predict the cure reaction up to approximately 60% of the reaction.
Prediction of Contra-Rotating Open Rotor broadband noise in isolated and installed configurations

Broadband noise is a significant part of the noise emitted by contra-rotating open rotors. Several noise sources can contribute to the total broadband sound field, with the most dominant ones probably being trailing edge noise, rotor-wake interaction noise and pylon-wake interaction noise. This paper addresses the prediction of these noise sources using analytical models based on Amiet’s flat plate airfoil theory and also to empirical turbulence models, fed by input data extracted from steady and unsteady CFD RANS simulations. The models are assessed against wind tunnel tests of Rolls-Royce’s rig 145 (build 1) conducted at the DNW anechoic open jet test facility using Rolls-Royce blades and Airbus pylons. The study showed promising results in terms of the ability of the models to predict acoustic power spectrum shapes, peak frequencies and absolute levels. The effects of changes in thrust on broadband wake-interaction noise are well reproduced. However, the models significantly underestimate the effect of thrust on trailing edge noise and the effect of rotational velocity on pylon interaction noise.
A Planning Model for Optimizing Locations of Changeable Message Signs

Changeable Message Signs (CMS) are commonly utilized by transportation agencies to inform motorists of traffic, roadway, and environmental conditions. They may be used to provide information, such as delay and alternate route guidance, in the event of an incident, construction or a roadway closure. The effectiveness of CMS in managing freeway traffic, however, is a function of many factors including the number of CMS installations, the location of CMS, the messages displayed, varied traffic network characteristics, and drivers’ response to incident conditions and CMS information. The objective of this thesis is to develop a CMS location planning model that can be used by transportation agencies to develop a CMS location plan that could achieve the largest long-term benefit to the system. This research is mainly motivated by the lack of systematic, robust and practical methods for locating CMS. State-of-practice methods rely mostly on the practitioner’s experience and judgement. Other methods fail to incorporate reasonable driver behaviour models, consider time-varying demand, allow for computational efficiency on large networks, or consider the spatial variation of incidents on a traffic network. A new CMS location optimization model has been developed that is unique in both model realism and computational efficiency. The model incorporates several components to estimate incident delay, predict driver response, estimate network-wide benefit, and choose those CMS locations that would provide the most benefit. Deterministic queuing methods are used in conjunction with historic incident characteristics to approximate the delay impact of an incident with and without CMS. A discrete choice model is used to predict the rate at which drivers would switch from the incident route to a less congested alternative under CMS information. A network traffic assignment model is then incorporated in an attempt to estimate the resulting traffic induced by incidents. Genetic algorithms are
Influence of plant growth regulators on growth and lowering parameters of watermelon (Citrullus lanatus (Thunb) Mansf.) CV. sugar baby

W (Citrullus lanatus (Thunb) Mansf. ) is believed to be the native of Africa (Harry, 2015). Watermelon has high nutritive value, is rich in vitamin ‘C’, low in sugar and calories because of high per cent of water (Bose et al., 2002). Watermelon is used mainly as a dessert and rind is used to some extent in making preserves and pickles. The raw fruits can be used for pickling and candy making. The fruits are very seldom cooked as vegetable when immature. In India, watermelon is grown in about 1.16 lakh hectare areas with the production of 3.16 million MT (Anonymous, 2019-20).
Determining residuary resistance per unit weight of displacement with Symbolic Regression and Gradient Boosted Tree algorithms

Determining the residuary resistance per unit weight of displacement is one of the key factors in the design of vessels. In this paper, the authors utilize two novel methods – Symbolic Regression (SR) and Gradient Boosted Trees (GBT) to achieve a model which can be used to calculate the value of residuary resistance per unit weight, of displacement from the longitudinal position of the center of buoyancy, prismatic coefficient, length-displacement ratio, beam-draught ratio, length-beam ratio, and Froude number. This data is given as results of 308 experiments provided as a part of a publicly available dataset. The results are evaluated using the coefficient of determination (R2) and Mean Absolute Percentage Error (MAPE). Pre-processing, in the shape of correlation analysis combined with variable elimination and variable scaling, is applied to the dataset. The results show that while both methods achieve regression results, the result of regression of SR is relatively poor in comparison to GBT. Both methods provide slightly poorer, but comparable results to previous research focussing on the use of “black-box” methods, such as neural networks. The elimination of variables does not show a high influence on the modeling performance in the presented case, while variable scaling does achieve better results compared to the models trained with the non-scaled dataset.
A wideband EBG structure with 1D compact microstrip resonant cell

This paper presents the design of novel 1D compact microstrip resonant cells (CMRC). Several thin line arrays in the 50Ω microstrip line with special configurations are fabricated without the requirement of any additional process. Three cells of the proposed structure can provide a wide stopband of −10 dB from 12.7 to 35.9 GHz and −30 dB from 13.8 to 35.9 GHz, respectively. This novel CMRC structure can be used for various compact and wideband microwave‐circuit applications. © 2005 Wiley Periodicals, Inc. Microwave Opt Technol Lett 45: 386–387, 2005; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.20831