Miracle-dz/UniFAR-FTUs huggingface dataset:
Diverse Transcriptome Responses to Salinity Change in Atlantic Cod Subpopulations

Adaptation to environmental variation caused by global climate change is a significant aspect of fisheries management and ecology. A reduction in ocean salinity is visible in near-shore areas, especially in the Baltic Sea, where it is affecting the Atlantic cod population. Cod is one of the most significant teleost species, with high ecological and economical value worldwide. The population of cod in the Baltic Sea has been traditionally divided into two subpopulations (western and eastern) existing in higher- and lower-salinity waters, respectively. In recent decades, both Baltic cod subpopulations have declined massively. One of the reasons for the poor condition of cod in the Baltic Sea is environmental factors, including salinity. Thus, in this study, an oligonucleotide microarray was applied to explore differences between Baltic cod subpopulations in response to salinity fluctuations. For this purpose, an exposure experiment was conducted consisting of salinity elevation and reduction, and gene expression was measured in gill tissue. We found 400 differentially expressed genes (DEGs) involved in the immune response, metabolism, programmed cell death, cytoskeleton, and extracellular matrix that showed a subpopulation-dependent pattern. These findings indicate that osmoregulation in Baltic cod is a complex process, and that western and eastern Baltic cod subpopulations respond differently to salinity changes.
Adhesion G Protein-Coupled Receptor G2 Promotes Hepatocellular Carcinoma Progression and Serves as a Neutrophil-Related Prognostic Biomarker

Adhesion G protein-coupled receptor G2 (ADGRG2) is an orphan adhesion G protein-coupled receptor (GPCR), which performs a tumor-promoting role in certain cancers; however, it has not been systematically investigated in hepatocellular carcinoma (HCC). In the current study, we utilized multiple databases to analyze the expression and diagnostic and prognostic value of ADGRG2 in HCC and its correlation with immune infiltration and inflammatory factors. The function and upstream regulatory miRNA of ADGRG2 were validated through qPCR, Western blot, CCK8, wound healing, and dual luciferase assays. It turned out that ADGRG2 was significantly higher in HCC and had a poor survival rate, especially in AFP ≤ 400 ng/mL subgroups. Functional enrichment analysis suggested that ADGRG2 may be involved in cancer pathways and immune-related pathways. In vitro, siRNA-mediated ADGRG2 silencing could inhibit the proliferation and migration of Huh7 and HepG2 cells. There was a highly significant positive correlation between ADGRG2 and neutrophils. Moreover, NET-related genes were filtered and confirmed, such as ENO1 and S100A9. Meanwhile, the high expression of ADGRG2 was also accompanied by the highest number of inflammatory cytokines, chemokines, and chemokine receptors and good immunotherapy efficacy. Finally, AGDGR2 may be sensitive to two drugs (PIK-93 and NPK76-II-72-1) and can be targeted by miR-326. In conclusion, ADGRG2 may serve as a novel biomarker and drug target for HCC diagnosis, immunotherapy, and prognosis and was related to neutrophils and the inflammatory process of liver cancer development.
Seismic Earth Pressures on Deep Building Basements

The International Building Code and ASCE 7-05 require that earth retaining structures and basement walls be designed for seismic earth pressures. Although there are many documented failures of retaining structures during earthquakes, almost all are associated with some form of soil-related failure in loose or poorly compacted soils in waterfront or marine locations or associated with embankments, slope instability or liquefaction. On the other hand, there have been no reports of damage to building basement walls as a result of seismic earth pressures in recent United States earthquakes including the 1971 San Fernando, 1987 Whittier Narrows, 1989 Loma Prieta and 1994 Northridge earthquakes, or in the 1995 Kobe, Japan or 1999 Chi Chi, Taiwan earthquakes. However, despite the absence of compelling damage or failure due to seismic earth pressures, inclusion of seismic earth pressures is required in the design of earth retaining structures and basement walls in the current United States building code. Most geotechnical engineers estimate seismic earth pressures using the Mononobe-Okabe method of analysis developed in the 1920s based on model tests of walls with sand backfill on a small shake table. The results from the original MononobeOkabe method have been compared to more recent tests which allow superior geometric and material property scaling using wall and soil models shaken in a centrifuge. The centrifuge tests strongly suggest that the Mononobe-Okabe methodology does not properly model full scale conditions and may be extremely conservative in the predicted seismic earth pressures. In addition, many geotechnical engineers are uncertain about the various inputs to the Mononobe-Okabe method which adds more unpredictability in the reported results. The applicability of the Mononobe-Okabe method to non-sandy backfill is also an issue. Based on the recent research, provisional recommendations for the design of building basement walls are presented, and the impact on the structural design of the basements is discussed.
Thermal structure and melting conditions in the mantle beneath the Basin and Range province from seismology and petrology

To better constrain the temperature structure in the upper mantle, we jointly invert seismic surface wave velocities and basalt thermobarometry. New measurements of the water concentration (1.0–3.5 wt %) and oxygen fugacity (FMQ + 0.5 to + 1.5) of basalts from seven recently active volcanic fields in the Basin and Range province (Cima, Pisgah, Amboy, Big Pine, Black Rock, Snow Canyon, W. Grand Canyon) enable more accurate equilibration pressure (P) and temperature (T) estimates of the mantle melts. We developed a revised thermobarometer that more precisely predicts the results of laboratory experiments on melts equilibrated with olivine and orthopyroxene and accounts for the effects of water and CO2. Applying these methods to basalts from the Basin and Range we find that most equilibrated near the dry solidus in P‐T space and at depths in the vicinity of the lithosphere‐asthenosphere boundary (LAB) inferred from receiver function analysis and Rayleigh surface wave tomography. The wet basalts should have begun melting well below the dry solidus, so the depths of equilibration probably reflect ponding of rising melts beneath the nominally dry lithosphere. A two‐parameter thermal model is sufficient to simultaneously satisfy both the seismological and petrological constraints. In the model, the depth to the dry solidus defines the bottom boundary of the conductive lid, while the potential temperature (Tp) controls the asthenosphere and LAB thermal structure. The optimum estimates of Tp range from <1300 to >1500°C, and depths to the LAB range from ∼55 to 75 km, with uncertainties on the order of ±50°C and ±10 km. In contrast to standard tomographic images or basalt thermobarometry, the output of the joint inversion is a geotherm that can be tested quantitatively against other observations.
Catalytic Reduction of Acetophenone Promoted with Quinuclidinol-Based Quaternary Ammonium Ionic Liquid as a Sustainable Solvent

: As a new sustainable catalyst and green solvent, ionic liquid has important applications in catalytic reduction. In this study, four quinuclidinol-based quaternary ammonium ionic liquids (ILs)were at ﬁrst prepared using simple procedures, and then they were used as catalyst for acetophe-none reduction. The main catalytic conditions were studied and screened through a comparison among the reaction results. It showed that the highest yield of 1-phenylethanol was 88.6% when [MenQu]Cl was used as a catalyst; the ideal solvent was ethanol; the amount of catalyst was 20 mol%, and the reaction temperature was 25 ◦ C. More substrates were employed to validate the universality of the developed method using such an IL. Moreover, potential reaction mechanisms and an IL recovery method were also suggested, which laid the foundation for its further applications in the ﬁeld of sustainable chemistry and cleaner industrial production.
Lithospheric flexure, uplift, and landscape evolution in south-central England

The high level river gravels in Oxfordshire (the Northern Drift Group), which range in age from Early Pleistocene to around 450 ka, contain pebbles that were derived from a source area to the north near Birmingham. The pebbles could not have been transported across the Upper Triassic and Lower Jurassic clay outcrops of the Midlands unless the region was at or close to sea level. The present day Cotswold escarpment ranges from 70 to 215 m: this uplift must therefore have occurred after deposition of the Northern Drift Group, when the drainage of the Midlands appears to have shifted from towards the Thames basin to the Bristol Channel area. It is concluded that lithospheric flexure due to the removal of >500 km3 of soft Late Triassic and Early Jurassic clays and marls from large areas of the Midlands and their re-deposition in the Celtic Deep might account for this Late Pleistocene uplift. Uplift in the Midlands is the likely explanation for both the tilted (approximately 0.3°) plateau surface in north Oxfordshire and the change in strike of the Jurassic beds SW of Northamptonshire. Although some uplift occurred in SE England during the Early Cenozoic and Miocene, we demonstrate here that there has been significant uplift of the region in the Late Pleistocene. The tilted plateau surface in north Oxfordshire may therefore be a relatively young (i.e. post-450 ka) feature related to tectonic uplift in the Midlands.
COVID-19 Vaccine Hesitancy among Unvaccinated Adults: A Cross-Sectional Exploratory Analysis of Vaccination Intentions in Italy Related to Fear of Infection

From the initial COVID-19 outbreak, Italy was the first Western country to be seriously affected by the pandemic. Understanding vaccine hesitancy can help efforts to achieve broad vaccination coverage. The objectives of this research were to determine the extent of vaccine hesitancy in Italy and to understand the characteristics of those segments of the population with some hesitancy. Between January and February 2021, 41,473 subjects answered the second questionnaire delivered in phase II of the web-based EPICOVID19 survey. Among the included adult volunteers living in Italy, 4653 (11.2%) reported having previously received at least one dose of the COVID-19 vaccine. In the sample of 36,820 respondents, all not vaccinated (age 51.1 ± 13.5; 59.7% female; 63.6% high level of education), the comparison between hesitant and inclined participants was accompanied by percentages and odds ratios. A total of 2449 individuals were hesitant (6.7% of the unvaccinated ones). Hesitancy was higher among women (OR = 1.48; 95%CI: 1.36–1.62); it was highest in the 50–59 and 40–49 age groups and among those with a lower educational level. A higher level of education was associated with a lower proportion of hesitancy (5.54%) compared with 9.44% among respondents with a low level of education (OR = 0.56; 95%CI: 0.46–0.68). Hesitancy was most common in subjects who did not report fear of infection (12.4%, OR = 4.0; 95%CI: 3.46–4.61). The results can guide the design of tailored information and communication campaigns through considering objective and subjective characteristics.
Location Accuracy Optimization in Bluetooth Low Energy (BLE) 5.1-Based Indoor Positioning System (IPS)—A Machine Learning Approach

Indoor Positioning System (IPS) is a technology used to locate and track objects or people inside buildings, by using sensors, wireless networks, or other means to determine their position. IPS has many applications in various fields such as healthcare, retail, logistics, and security. Achieving IPS of high location accuracy is yet to be explored further. In this experimental research, an IPS based on Bluetooth Low Energy (BLE) 5.1 protocol is implemented and two optimization techniques, parameters calibration and application of Machine Learning Algorithm (MLA) are proposed to improve location accuracy. In Stage 1 of this experiment, the measured Root Mean Square Error (RMSE) value before optimization yielded location accuracy of 0.670m. In Stage 2, four different parameters which include elevation angle, tag height, data rate and walking pace are calibrated and tested. Besides, in Stage 2, three different algorithms which include Support Vector Regression (SVR), Decision Tree (DT) and K-Nearest Neighbor (KNN) are evaluated. As a result, parameters calibration decreased RMSE value down to 0.219m. Additionally, among all three MLAs, KNN illustrated the lowest RMSE value of 0.631m. In Stage 3, the lowest RMSE value of 0.015m is obtained by combining parameters calibration and MLA approaches which improved location accuracy up to 98.5%. The developed framework is operational at our industry partner, ams OSRAM’s LED wafer fabrication cleanroom facility.
A place on the corner

This paperback edition of "A Place on the Corner" marks the twenty-fifth anniversary of Elijah Anderson's sociological classic, a study of street corner life at a local barroom/liquor store located in the ghetto on Chicago's South Side. Anderson returned night after night, month after month, to gain a deeper understanding of the people he met, vividly depicting how they created-and recreated-their local stratification system. In addition, Anderson introduces key sociological concepts, including "the extended primary group" and "being down. " The new preface and appendix in this edition expand on Anderson's original work, telling the intriguing story of how he went about his field work among the men who frequented Jelly's corner.
The Hydraulic Autogenesis of Distinct Cyclicity in Delta Foreset Bedding: Flume Experiments

Abstract We report the experimental discovery of autogenic cyclicity in delta foreset bedding that arises simply from steady water and sediment input under particular hydraulic characteristics. This autogenesis is intrinsic to Froude-supercritical flow associated with a train of upstream-migrating hydraulic jumps that delineate cyclic steps. Upstream migration of hydraulic jumps is associated with discrete packages of sediment accumulation on the foreset slope. This synchronism originates from the periodic alternation between supercritical and subcritical flow states on the delta topset just upstream of the shoreline, i.e., the topset–foreset break of the delta. The alternation in turn depends on the distance from the topset–foreset break to the nearest hydraulic jump immediately upstream. When the hydraulic jump is still in close proximity to the river mouth (delta shore), it reworks existing topset deposits (and perhaps upper foreset deposits as well) as it migrates upstream. Reworked sediment is then entrained into the subcritical flow between the shore and the hydraulic jump, which then emplaces this fine suspended sediment onto the foreset slope. As the hydraulic jump moves sufficiently far upstream of the mouth, the topset flow becomes supercritical, with a flow velocity sufficient to transport fine sediment offshore beyond the foreset. Under these conditions, the sediment emplaced on the foreset tends to be coarser material deposited via avalanching or proximal deposition from suspension. The details of this selective sedimentation vary according to the material in the topset bed near the mouth that is available for entrainment into the subcritical flow. Regardless of the details, however, distinct cyclic sedimentation of the delta foreset can be sustained as long as the inflow conditions of water and sediment dictate the formation of cyclic steps on the alluvial bed of the topset. Such hydraulic autogenesis accounts for a set of stratigraphic features that are common in ancient Gilbert deltas.
Application of Good Corporate Governance Principles to the Quality of Financial Statements

This study aims to determine the effect of the application of good corporate governance principles on the quality of financial statements of the Wair Pu'an Drinking Water Regional Public Company, Sikka Regency. The data collection technique in this study used questionnaires distributed by 64 employees which were then processed using the SPSS 25 program. The analytical method for testing hypotheses is multiple linear regression analysis. The results of the statistical test t (partial) show that Transparency (X1) has a significant effect on the quality of financial statements (Y), Accountability (X2) has a significant effect on the quality of financial statements (Y), Accountability (X3) has a significant effect on the quality of financial statements (Y), independence (X4) has an insignificant effect on the quality of financial statements (Y), fairness (X5) has an insignificant effect on the quality of financial statements (Y). Based on statistical test F (simultaneous) shows that Transparency (X1), Accountability (X2), Accountability (X3), Independence (X4), and Fairness (X5) have a significant effect on the Quality of Financial Statements.
Association of Chronic Medical Conditions With Severe Outcomes Among Nonpregnant Adults 18–49 Years Old Hospitalized With Influenza, FluSurv-NET, 2011–2019

Abstract Background Older age and chronic conditions are associated with severe influenza outcomes; however, data are only comprehensively available for adults ≥65 years old. Using data from the Influenza Hospitalization Surveillance Network (FluSurv-NET), we identified characteristics associated with severe outcomes in adults 18–49 years old hospitalized with influenza. Methods We included FluSurv-NET data from nonpregnant adults 18–49 years old hospitalized with laboratory-confirmed influenza during the 2011–2012 through 2018–2019 seasons. We used bivariate and multivariable logistic regression to determine associations between select characteristics and severe outcomes including intensive care unit (ICU) admission, invasive mechanical ventilation (IMV), and in-hospital death. Results A total of 16 140 patients aged 18–49 years and hospitalized with influenza were included in the analysis; the median age was 39 years, and 26% received current-season influenza vaccine before hospitalization. Obesity, asthma, and diabetes mellitus were the most common chronic conditions. Conditions associated with a significantly increased risk of severe outcomes included age group 30–39 or 40–49 years (IMV, age group 30–39 years: adjusted odds ratio [aOR], 1.25; IMV, age group 40–49 years: aOR, 1.36; death, age group 30–39 years: aOR, 1.28; death, age group 40–49 years: aOR, 1.69), being unvaccinated (ICU: aOR, 1.18; IMV: aOR, 1.25; death: aOR, 1.48), and having chronic conditions including extreme obesity and chronic lung, cardiovascular, metabolic, neurologic, or liver diseases (ICU: range aOR, 1.22–1.56; IMV: range aOR, 1.17–1.54; death: range aOR, 1.43–2.36). Conclusions To reduce the morbidity and mortality associated with influenza among adults aged 18–49 years, health care providers should strongly encourage receipt of annual influenza vaccine and lifestyle/behavioral modifications, particularly among those with chronic medical conditions.
The 20,000-years-long sedimentary record of the Lesina coastal system (southern Italy): From alluvial, to tidal, to wave process regime change

The present-day Lesina area (Adriatic coast of southern Italy) preserves in the subsurface the stratigraphic signature of a recent sedimentary process regime change, which was responsible for the conversion of a former alluvial plain into a back-barrier tidal flat and, finally, into the modern barrier island. Facies-based analyses of the first 55 m of the upper Pleistocene–Holocene stratigraphic record, integrated with biostratigraphic sampling, radiocarbon data, and aerial observations of some diagnostic relict morphologies, allowed us to reconstruct the history of the last 20,000 years of this area. The succession investigated is adjacent to a salt dome, which uplifted in recent times, forming the easternmost boundary of the present-day Lesina lagoon. Three main stratigraphic intervals were detected in the subsurface: the lowermost unit is made up of conglomerates, sandstones, and mudstones of terrestrial origin, belonging to a complex system of alluvial plain filling a pre-existing Last Glacial Maximum (LGM) topography. The second interval consists of sands and muds, with subordinate conglomerates of brackish and marine origin, and lies on the previous one through a wide ravinement. Its composing lithofacies exhibit a strong tidal signature preserved in tidal rhythmites belonging to a net of tidal channels, associated with marshes, mud flat, and lagoonal deposits. These sediments record the emplacement of a back-barrier tidal flat, which developed under the strong influence of a tidal influx enhanced by the late post-LGM transgression. The third uppermost interval resulted from the deposition of coastal-marine sands and gravels accumulated during the ensuing modern normal regression, under the dominance of a wave-dominated coastal dynamics, which was responsible for the progradation of the present-day beach barrier and the closure of the Lesina lagoon. The paleogeography of the back-barrier tidal flat preceding the onset of the modern barrier island is thus reconstructed based on the results of our facies analysis, biostratigraphy, and AMS dating. Many of the elements composing this mid-Holocene tide-influenced system were also interpreted from the aerial-photograph observation of several relict morphologies, which are still preserved in many parts of the modern Lesina barrier island. We propose some new interpretation on the origin some of these elements, which possibly developed under sedimentary process regimes different from the modern ones, including some flood-tidal deltas, previously interpreted as tsunami-derived washover fans.
CoDesignS Education for Sustainable Development: A Framework for Embedding Education for Sustainable Development in Curriculum Design

In the context of the global climate change debate, the integration of Education for Sustainable Development (ESD) in higher education institutions (HEIs) has been identified as one of the top priorities. This paper presents the CoDesignS ESD Framework (hereafter “Framework”) focused on HEIs, though the Framework is applicable to other types of educational institutions. The Framework introduces transformative pedagogies and teaching methods that extend beyond typical ESD competencies, encompassing cognitive, socio-emotional, and behavioral domains for a holistic design and delivery. It was evaluated using a focus group and interviews among sustainability practitioners and academics, learning and curriculum designers, students, and government officials involved in ESD. The evaluation demonstrates key stakeholders’ engagement with the Framework and appreciation of its potential to integrate sustainability into university curricula across different disciplines. The findings suggest that the Framework is easy to use, making sustainability explicit in the curriculum and actively developing the competencies students require to bring about change beyond the classroom. The feedback received has helped the further development of the Framework, including the CoDesignS ESD Toolkit Planner and Dashboard, which provide a more effective way of integrating the learning design and ESD components embedded as part of the CoDesignS ESD pillars.