Miracle-dz/UniFAR-FTUs huggingface dataset:
Impact of CYP3A7, CYP2D6 and ABCC2/ABCC3 polymorphisms on tacrolimus steady state concentrations in Bulgarian kidney transplant recipients

Abstract Polymorphisms in the genes of drug-metabolizing enzymes have the potential to contribute to inter-individual differences in drug pharmacokinetics and toxicity. A custom next-generation sequencing (NGS) panel was used in 71 kidney transplanted patients to study the polymorphisms of 11 genes relevant to the metabolism of immunosuppressive drugs. Cyclosporine A and tacrolimus concentrations were determined by a validated liquid chromatography with tandem mass spectrometry (LC-MS/MS) method. More than 1000 polymorphisms were found in the studied 11 genes, and 45% of them were different non-synonymous variants. Eleven missense mutations were observed in the CYP3A7 gene, resulting in increased metabolism of tacrolimus at day 21 post-transplantation (6.7 µg/L vs. 10.3 µg/L; p = 0.048). Two alleles encoding a cytochrome P450 2D6 enzyme with impaired function—CYP2D6*4 (non-functional) and CYP2D6*10 (decreased function), were found in the studied group and both of them were associated with higher levels of tacrolimus at day 14 (10.1 µg/L; p = 0.021 and 9.7 µg/L; p = 0.036, vs. 7.7 µg/L respectively). Altered function of ABC transporters C3 and C2 was also associated with increased TAC concentration. ABCC3 significantly influenced TAC metabolism by itself, but polymorphisms affecting both ABCC3 and ABCC2 resulted in higher changes: 13.6 µg/L vs. 7.9 µg/L, day 14 (p = 0.003) and 20 µg/L versus 9.3 µg/L, day 21 (p = 0.019). All associations were also checked for variants affecting the activity of CYP3A4 and CYP3A5. Despite its small size, the study points out that the pharmacogenetics of calcineurin inhibitors may also be influenced by other genes besides CYP3A4 and CYP3A5.
Orchestrating the Dermal/Epidermal Tissue Ratio during Wound Healing by Controlling the Moisture Content

A balanced and moist wound environment and surface increases the effect of various growth factors, cytokines, and chemokines, stimulating cell growth and wound healing. Considering this fact, we tested in vitro and in vivo water evaporation rates from the cellulose dressing epicitehydro when combined with different secondary dressings as well as the resulting wound healing efficacy in a porcine donor site model. The aim of this study was to evaluate how the different rates of water evaporation affected wound healing efficacy. To this end, epicitehydro primary dressing, in combination with different secondary dressing materials (cotton gauze, JELONET◊, AQUACEL® Extra ™, and OPSITE◊ Flexifix), was placed on 3 × 3 cm-sized dermatome wounds with a depth of 1.2 mm on the flanks of domestic pigs. The healing process was analyzed histologically and quantified by morphometry. High water evaporation rates by using the correct secondary dressing, such as cotton gauze, favored a better re-epithelialization in comparison with the low water evaporation resulting from an occlusive secondary dressing, which favored the formation of a new and intact dermal tissue that nearly fully replaced all the dermis that was removed during wounding. This newly available evidence may be of great benefit to clinical wound management.
The Relationship Between Dental and Skeletal Maturity Die Beziehung zwischen dentaler und skelettaler Reife

Object: The purpose of this investigation was to evaluate the relationships between dental and skeletal maturity, primarily whether it is possible to assess skeletal maturity by dental maturity without reference to hand-wrist radiographs. Patients and Methods: Research was carried out with a representative sample of 422 children (276 girls, 146 boys) aged 91‐168 months. The investigated materials included a pre-treatment left hand-wrist radiograph plus dental panoramic and periapical radiographs. Results: Spearman rank-order correlation analysis showed that a rho value of 0.588 between skeletal maturity level and lower first premolars was the lowest, and a rho value of 0.800 between skeletal maturity level and body height the highest in girls. In boys, a rho value of 0.474 between skeletal maturity level and upper canine was the lowest, and a rho value of 0.761 between skeletal maturity level and body height the highest. Conclusion: The relationship between dental maturity and skeletal maturity is not sufficient for dental maturity to be used as a substitute for skeletal maturity.
Stress and Coping Strategies among Pregnant Women attending Antenatal Clinic of a Teaching Hospital in eastern Nepal

Aim: To find out the stress and coping strategies among pregnant women attending antenatal clinic. Methods: A descriptive, cross-sectional research design was used for the study. The sample was taken from an antenatal outpatient department of Nobel Medical College Teaching Hospital. A total of 300 pregnant women was selected by using non- probability consecutive sampling technique. Data was collected by using standard tool, Pregnancy Stress Rating Scale (PSRS) and Brief Cope. Data analysis was done by descriptive and inferential statistics. Results: The study revealed that 40.7% of the respondents experienced a high level of stress and 84.0% of respondents had used adequate coping strategies where “self- distraction” was the most used coping strategy by the respondents with a mean score (2.99±.56). Stress and coping strategies had positive mild correlation (r=0.040). Conclusions: More than one-third of the respondents had experienced a high -level stress and the majority of the respondents had used adaptive coping strategies. The different methods of coping strategies during pregnancy should be expanded as per the best available evidence to lower stress and other adverse outcomes of stress. Keywords: Brief cope, coping strategies, pregnancy stress rating scale, stress
Is the Syntax-Prosody Interaction ‘Unidirectional’?

The three major components of linguistics – sounds, meaning, and syntax – have been believed to interact with each other, and an interesting area of research which became active since the 1980s was the interplay between sounds and syntax, for example, Selkirk (1980). Since syntax predominantly deals with the structure of sentences and constituency of utterance components, the subfield within sounds that received most attention from linguists was prosody, which – in phonology – is concerned with how sounds are hierarchically organised together, that is, prosodic structure (Féry 2017). Interestingly, the more phonetically defined prosody, which refers to the ‘phenomena that involve the acoustic parameters of pitch, duration and intensity’ (Ladd & Cutler 1983: 1), has also been found to interact with syntax, for example Truckenbrodt (1995). This essay aims to review and summarise the key research done on the interface of syntax and prosody, in both phonological and phonetic senses. In the remainder of the paper, section 2 will look at the connection between syntactic structures and prosodic structures in phonology, while section 3 will focus on how the suprasegmental measurements of sounds in phonetics respond to syntactic structures and phenomena. Within each section, my goal is to challenge the idea that syntax is having impacts on prosody and such influence is ‘unidirectional’,1 for example Zwicky & Pullum (1986), and to demonstrate with empirical evidence that prosody is, in fact, having significant impacts on syntax too. Section 4 will conclude and make some final remarks.
COMPARISON OF UNCERTAINTY QUANTIFICATION METHODS FOR CNN-BASED REGRESSION

Abstract. The evaluation of reliability is not only of high importance for safety-critical deep learning applications but for object pose estimation as well. The uncertainty of the result is one way to express its reliability. In order to better understand existing uncertainty quantification (UQ) methods and their performance on image-based regression tasks, we use a small CNN and various scenarios to evaluate the estimated uncertainties. The evaluation is done on different simplistic synthetic datasets, consisting of gray-scale images of squares on a darker background. We train the CNN to predict the square center position of the square in the image. We compare how different UQ methods perform under dataset shift, rotation, occlusion, noise changes in the images.
The ABC Model of Happiness—Neurobiological Aspects of Motivation and Positive Mood, and Their Dynamic Changes through Practice, the Course of Life

Simple Summary This article proposes a new model for exploring happiness primarily from a neurobiological perspective. Such understanding includes the dynamics of positive mood states and how they change throughout life. Happiness is not a cognitive construct: it is an immediate emotional experience—a feeling that relies on neurophysiological activation in the brain’s reward system. With this in mind, three types of happiness are proposed: (A) wanting, approaching, and pleasure, (B) avoiding, departing, and relief, (C) non-wanting, staying, and satisfaction. Behind this is a sophisticated (neuro)biological dynamic, ranging from the search for autonomy and ecstasy, which is particularly characteristic of young people, to the way we cope with stress, as we find it pronounced in the middle-aged, to deep contentment, peace, and inner joy, as it is mainly attributed to older people. Paradoxically, it is in fact the elderly who appear to be the happiest and most content—this phenomenon is also known as the “satisfaction paradox”. Apparently, these dynamic changes in happiness can be amplified with practice. Happiness is biological in this context, but can still be “learned”. Contemplative practices can serve as an example here to demonstrate this trainability, and they may themselves influence the course of happiness. Abstract Background: Happiness is a feeling, an immediate experience, not a cognitive construct. It is based on activity in the brain’s neurobiological reward and motivation systems, which have been retained in evolution. This conceptual review provides an overview of the basic neurobiological principles behind happiness phenomena and proposes a framework for further classification. Results: Three neurobiologically distinct types of happiness exist: (A) wanting, (B) avoiding, and (C) non-wanting. Behind these types lies a dynamic gradation, ranging from the more youthful anticipation, pleasure and ecstasy (A), to stress processing, escape and relief (B) as we find them accentuated in the middle-aged, to deep satisfaction, quiescence and inner joy (C), which is particularly attributed to older people. As a result, the development of happiness and satisfaction over the course of life typically takes the form of a U-curve. Discussion: The outlined triad and dynamic of happiness leads to the paradoxical finding that the elderly seem to be the happiest—a phenomenon that is termed “satisfaction paradox”. This assumed change in happiness and contentment over the life span, which includes an increasing “emancipation” from the idea of good health as a mandatory prerequisite for happiness and contentment, can itself be changed—it is trainable. Conclusions: Programs for mindfulness, contemplation, or stress reduction, including positive psychology and mind–body/behavioral medicine training, seem to be capable of influencing the course happiness over time: Happiness can be shaped through practice.
Characteristics of Fluoroquinolone-Resistant Escherichia Coli from Broiler Chickens with Colibacillosis

Characteristics of Fluoroquinolone-Resistant Escherichia coli from Broiler Chickens with Colibacillosis Mohamed S. Hussein, Hanan A. Fahmy, Ashraf A. Abd El Tawab 1 Department of Bacteriology, Kafr El-Sheikh Laboratory, AHRI, Agricultural Research Center (ARC), Egypt 2 Department of Biotechnology, AHRI, Dokki, Giza, Agricultural Research Center (ARC), Egypt. 3 Department of Bacteriology, Immunology and Mycology, Faculty of Veterinary Medicine, Benha University, Egypt
COMPARATIVE STUDY BETWEEN LAPAROSCOPIC AND ULTRASOUND GUIDED TRANSVAGINAL OVARIAN DRILLING IN POLYCYSTIC OVARY SYNDROME

Background: Polycystic ovary syndrome is a heterogeneous clinical syndrome, which has been defined as the association of hyperandrogenism with chronic anovulation in women without specific adrenal and pituitary gland disease. Objective: To compare the effect of laparoscopic ovarian drilling and ultrasonographic transvaginal ovarian drilling on patient with polycystic ovaries. Patient and Methods: Forty women with ultrasonographic as well as clinic and /or biochemical findings consistent with PCOs will be recruited into the study from the outpatient infertility clinic at Syed Galal hospital between June 2015 and June 2016. All patients in the study are seeking for treatment of infertility. These patients are randomly divided into two groups; one group has traditional laparoscopic ovarian drilling while the other group has transvaginal ultrasonographic ovarian drilling. Results: that there was a significant increase in FSH in both groups after treatment, but the improvement was higher in GI. Conclusion: In this study we found that there was a restoration to normal cycle in both groups with marked improvement in GI than GII in all parameters (ovulation rate and pregnancy rate).
Remdesivir in the Treatment of COVID-19: A Propensity Score-Matched Analysis from a Public Hospital in New York City Assessing Renal and Hepatic Safety

While the relative efficacy of remdesivir as a therapeutic agent in selected patients with COVID-19 has been established, safety concerns have been raised regarding potential nephrotoxicity and hepatotoxicity. Our main objective was to investigate the kidney- and liver-related safety outcomes in patients with COVID-19 treated with remdesivir in a public hospital in New York. A propensity score-matched retrospective study was conducted in hospitalized patients with COVID-19 from 1 June 2020 to 10 March 2021. A total of 927 patients were included in this study (remdesivir: 427, non-remdesivir: 500; women: 51.8%; median age 61 years; median BMI: 28.5 kg/m2). Matching without replacement yielded a cohort of 248 patients (124 in each group). In the matched cohort, the remdesivir group had a significantly lower rate of acute kidney injury (AKI) (12.1% vs. 21.8%, p = 0.042), a lower rate of acute liver injury (ALI) on the verge of statistical significance (7.3% vs. 14.5%, p = 0.067), and non-significantly lower death rate (13.7% vs. 16.1%, p = 0.593) compared to the non-remdesivir group. Multivariable analyses revealed that patients treated with remdesivir were found to be associated with a significantly lower likelihood for AKI (OR: 0.40; 95% CI: 0.24–0.67, p < 0.001), no association was found for ALI (OR: 0.68; 95% CI: 0.35–1.30, p = 0.241), while a trend towards an association of patients treated with remdesivir with a lower likelihood for in-hospital death was observed (OR: 0.57; 95% CI: 0.32–1.01, p = 0.053). In conclusion, no safety concerns with regards to renal and liver outcomes were raised in patients with COVID-19 treated with remdesivir. Instead, there were signals of possible nephroprotection and improved in-hospital mortality.
Desempenho de ovinos e respostas de pastagens de Florakirk (Cynodon spp) submetidas a regimes de desfolha sob lotação contínua

Pasture and animal responses of Florakirk swards were evaluated at four steady state conditions (sward surface heights (SSH) of 5, 10, 15 and 20 cm), established by sheep under continuous stocking and variable stocking rate from August/98 until April/99. SSH were allocated to experimental units according to a complete randomized block design with four replications. The responses evaluated were herbage nutritive value (crude protein (CP), neutral detergent fiber (NDF), acid detergent fiber (ADF) and lignin), in vitro organic matter digestibility (IVOMD), morphological composition of the herbage as grazed and of the sward, herbage accumulation rate and animal performance live (weight gain per animal and per area). The CP content varied from 16 to 24% and IVOMD from 70 to 80%. Herbage accumulation rates as well as animal performance were higher in summer than spring due to a higher availability of growth factors.
The possibilities of stem cell application in regenerative medicine

Abstract Stem cells are characterized by their ability to self-renew and differentiate into various cell types. They offer great potential for a wide range of applications, however, medical studies on the use of embryonal stem cells are largely limited to bioethical issues searching for alternative sources of stem cells, which include isolating cells from adult organisms or inducing pluripotentiality of somatic cells by administration of transcription factors. Nowadays, stem cells are used to study the mechanisms of cell differentiation and treat diseases that are commonly considered to be incurable, such as diabetes and neurodegenerative diseases, as well as enable regeneration of skin damage and myocardium. This review introduces the subject of stem cells, their sources and application in regenerative medicine.
Designing Long-term Parent-child-robot Triadic Interaction at Home through Lived Technology Experiences and Interviews

Social agents have been mostly designed to engage with children one-on-one as tutors or learning peers. Besides this child-robot dyadic interaction paradigm, they have the potential to empower parents to more actively interact with their children. Robot-assisted parent-child interaction could be a sustainable future approach for promoting children’s in-home learning. Motivated by this new design direction, this work takes an iterative design approach to explore how we design triadic interactions through "lived technology experiences" and interviews. For 3-6 weeks, we deployed and remotely teleoperated a social robot in the homes of 12 families with 3-7-year-old children to engage in a triadic story reading activity with both parent and child for six 25-min sessions. Before and after the deployment, we conducted a semi-structured interview with participants on their triadic interaction experience and desired robot design features. The results of our qualitative analysis show that social robots can improve various aspects of parent-child interaction. We propose design guidelines for robot-assisted parent-child interactions at home, the considerations of participants’ values around technology design, and promotion of their long-term lived technology experiences as critical sources for design knowledge.
Doing global investments the Nordic way Th e “ business case ” for Equinor ’ s support to union work among its employees in Tanzania

In the Nordic countries, unions are represented in company boards and can infl uence companies’ policies toward labor abroad. Th is article focuses on the Norwegian national oil company Equinor and its support of unionization of its employees in Tanzania. Th is was inspired by the Nordic tradition of social dialogue between corporations and strong, independent unions. Corporation managers and union representatives tend to refer to this social dialogue as “the Norwegian model,” but this is a narrow conceptualization of the model that disregards the role of the state. I argue that while it is benefi cial for the Tanzanian workers to be organized, it is probably also “good for business” to have unionized workers who have adopted the Nordic collaborative model, rather than a more radical union model.
MohaMed ahMed a.Fouda1, hithaM abdel-Saeed2*, Sherein S. abdelgayed3, oSSaMa

| Almost all dermatology patients have a primary or underlying disease that causes secondary infections. In this study, primary dermatological diseases were investigated as well as concurrent secondary infections to reach a definitive diagnosis that will lead to proper treatment and cure. The present work included 65 dogs which divided into 2 groups. Control group (20 apparently healthy dogs) and diseased group (45 dogs). All dogs were clinically examined; blood samples were collected for estimation of CBC (Complete blood count), ALT (Alanine Aminotransferase), AST (Aspartate Aminotransferase), GGT (gamma-glutamyl transferase), BUN (Blood urea nitrogen), Creatinine, Thyroid profile FT4 (free thyroxine-4), TSH (thyroid stimulating hormone) and Cortisol. Only diseased dogs were subjected to skin scraping examination while biopsies from skin lesions were obtained for histopathological examination. Results showed significant (P ≤0.01) leukocytosis in diseased group compared to control one. Skin scraping revealed mites infestation (sarcoptic mite), (Demodectic mite: demodex canis). Also, ectothrix and endothrix spores of dermatophytes were detected (Microsporum canis). Histopathological examination revealed various changes in epidermal as well as dermal layer in different dermopathies. Conclusion: the present work indicated that, clinical examination, skin scraping and laboratory tests (CBC, Biochemistry and hormonal profiles) for different dermopathies in dogs will drive to initial diagnosis, whereas histopathological examination for skin biopsies will guide to a definite diagnosis and furthermore specific therapeutic strategies.
Patient satisfaction and clinical assessment of surface roughness and wear of enamel antagonists for polished versus glazed posterior lithium disilicate glass ceramic crowns: A randomized controlled clinical trial

--Aim: To compare surface roughness of glazed versus polished lithium disilicate crowns as well as wear of enamel antagonists. Methodology: Twenty-two full coverage crowns were fabricated for posterior teeth. Scaling and polishing was performed for all the patients one week prior to preparation. The patients were divided into two groups according to crown finishing. Group 1(control group) fabricated from IPS e.max glazed crowns and Group 2 (intervention group) fabricated from IPS e.max polished crowns. The preparation was standardized with supra-gingival, chamfer finish line for all teeth. Fabrication of the crowns was done using lost wax press technique. The restorations were glazed with e.max ceram glazing liquid; an even layer was applied on the entire surface of the crown using a brush. Polishing was performed using EVE abrasive rubbers. Polishing of each crown was performed with rubbers of three different grains, beginning with the most abrasive one (light crimson) for shaping, then an intermediate one (crimson) for pre polishing, and the last, a less abrasive one (yellow)for high shine polishing. Self-adhesive cement was used for both groups. Roughness of crowns as well as