Miracle-dz/UniFAR-FTUs huggingface dataset:
Specialized and Geographic Distribution of Specialists in Iran in 2016 and its Estimates in 2026

3 داتسا يژولويمديپا و رامآ ،يتسيز زكرم تاقيقحت يزاسلدم رد ،تملاس هدكشهوژپ هدنيآ يهوژپ رد ،تملاس هاگشناد مولع يكشزپ ناريا ،نامرك 4 شناد ي را هورگ بلق و قورع ، هدكشناد كشزپ ي ، هاگشناد مولع كشزپ ي هش ي د تشهب ي ، ،نارهت ا ي نار 5 رايشناد هورگ يژولوتامه ،يژولوكنآ زكرم تاقيقحت ناطرس ،شراوگ هاگشناد مولع يكشزپ ،ناردنزام ،يراس ناريا 6 داتسا ي را هورگ س ي راذگتسا ي ،تملاس ناد هدكش شزومآ كشزپ ي ، هاگشناد مولع كشزپ ي هش ي د تشهب ي ، ،نارهت ا ي نار
Mobility enhancements for LTE-advanced multilayer networks with inter-site carrier aggregation

In this article we first summarize some of the most recent HetNet mobility studies for LTEAdvanced, and use these to highlight the challenges that should be further addressed in the research community. A state-of-the-art HetNet scenario with macros and small cells deployed on different carriers, while using inter-site carrier aggregation, is hereafter studied. Hybrid Het- Net mobility solutions for such cases are derived, where macrocell mobility is network controlled, while small-cell mobility is made UE-autonomous. The proposed scheme is characterized by having the UE devices autonomously decide small cell addition, removal, and change without any explicit signaling of measurement events to the network or any signaling of hand - over commands from the network. Hence, the proposed solution effectively offloads the network from having to perform frequent small cell handoff decisions, and reduces the signaling overhead compared to known network controlled mobility solutions. Results from extensive dynamic system-level simulations are presented to demonstrate the advantages of the proposed technique, showing significant savings in signaling overhead.
Early response to induction is predictive of survival in childhood Philadelphia chromosome positive acute lymphoblastic leukaemia: results of the Medical Research Council ALL 97 trial

We report on the outcome of children with Philadelphia positive acute lymphoblastic leukaemia (Ph+ ALL) treated on the UK Medical Research Council (MRC) trial for childhood ALL, MRC ALL 97, between January 1997 and June 2002. Forty‐two (2·3%) patients were Ph+. Nineteen (45%) had <25% blasts in bone marrow (BM) within the first 2 weeks of treatment and were defined as a good response group (GRG), the others as a poor response group (PRG). Thirty‐six (86%) achieved first complete remission (CR1) at the end of induction, of which 28 underwent BM transplantation (BMT). The median follow‐up was 42 months (range, 21–84). The 3‐year event‐free survival (EFS; 52%, 95% CI, 36–66%) was a considerable improvement on the previous MRC UKALL XI trial (27%). EFS for the GRG and PRG were 68% (43–84%) and 39% (18–59%), respectively (P = 0·03); presenting white cell count <50 × 109/l (P = 0·02) was predictive for overall survival. Changes in the MRC ALL97 trial within the study period resulted in some Ph+ ALL receiving daunorubicin and either prednisolone or dexamethasone during induction. Though the use of daunorubicin during induction was not a prospective study question, EFS was significantly better for those whose induction included this drug (P = 0·02). Steroid randomization was not stratified for Ph+ ALL patients and was not predictive for EFS. BMT in CR1 appeared to reduce the risk of a subsequent BM relapse. These results show significant improvement on previous MRC trials; future therapeutic strategies should include early intensive therapy and BMT in CR1.
Dysregulation of the mTOR Pathway Mediates Impairment of Synaptic Plasticity in a Mouse Model of Alzheimer's Disease

Background The mammalian target of rapamycin (mTOR) is an evolutionarily conserved Ser/Thr protein kinase that plays a pivotal role in multiple fundamental biological processes, including synaptic plasticity. We explored the relationship between the mTOR pathway and β-amyloid (Aβ)-induced synaptic dysfunction, which is considered to be critical in the pathogenesis of Alzheimer's disease (AD). Methodology/Principal Findings We provide evidence that inhibition of mTOR signaling correlates with impairment in synaptic plasticity in hippocampal slices from an AD mouse model and in wild-type slices exposed to exogenous Aβ1-42. Importantly, by up-regulating mTOR signaling, glycogen synthase kinase 3 (GSK3) inhibitors rescued LTP in the AD mouse model, and genetic deletion of FK506-binding protein 12 (FKBP12) prevented Aβ-induced impairment in long-term potentiation (LTP). In addition, confocal microscopy demonstrated co-localization of intraneuronal Aβ42 with mTOR. Conclusions/Significance These data support the notion that the mTOR pathway modulates Aβ-related synaptic dysfunction in AD.
Faster Mutation Testing Inspired by Test Prioritization and Reduction

S DR 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 Ran 7.38 1.58 9.65 1.34 6.49 1.83 4.87 1.06 14.86 3.27 10.48 0.99 1.13 0.22 8.10 2.75 12.38 2.28 7.47 t C1 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 Ran 9.06 1.18 10.00 1.44 7.08 1.64 6.05 0.28 14.79 3.03 13.33 0.50 1.34 0.17 11.31 2.36 13.45 2.20 9.14 a C2 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 Ran 7.41 0.95 10.15 0.68 5.42 1.67 4.30 0.26 13.33 2.48 10.10 0.43 1.10 0.15 6.97 1.85 10.97 1.62 7.03 t C3 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 Ran 8.57 1.08 10.22 1.34 7.05 1.67 5.21 0.22 17.12 3.39 12.65 0.44 1.29 0.12 11.31 2.53 13.18 1.80 8.76
Perturbative versus nonperturbative dynamics of the fuzzy S^2*S^2

We study a matrix model with a cubic term, which incorporates both the fuzzy S2 × S2 and the fuzzy S2 as classical solutions. Both of the solutions decay into the vacuum of the pure Yang-Mills model (even in the large-N limit) when the coefficient of the cubic term is smaller than a critical value, but the large-N behavior of the critical point is different for the two solutions. The results above the critical point are nicely reproduced by the all order calculations in perturbation theory. By comparing the free energy, we find that the true vacuum is given either by the fuzzy S2 or by the ``pure Yang-Mills vacuum'' depending on the coupling constant. In Monte Carlo simulation we do observe a decay of the fuzzy S2 × S2 into the fuzzy S2 at moderate N, but the decay probability seems to be suppressed at large N. The above results, together with our previous results for the fuzzy CP2, reveal certain universality in the large-N dynamics of four-dimensional fuzzy manifolds realized in a matrix model with a cubic term.
Parametric model order reduction technique for design optimization

Model order reduction has proven to be an effective tool for dealing with the computational complexity that arises during the simulation of large interconnect networks. However, in the case of parametric reduced order models, the effectiveness of traditional reduction methods is dependent on the number of moments and cross moments required to construct the orthonormal basis used in the congruence transformation. This can result in a relatively large reduced system in cases when the number of parameters is large. We propose a new approach for constructing the orthonormal basis that is not directly dependent on the moments. This new technique reduces a circuit with respect to many parameters by using singular value decomposition as a tool to filter out redundant information from the original subspaces. The result is a parametric reduced order model that is smaller, but still conserves the essential behavior of the original circuit as a function of frequency and other circuit parameters.
Serum Resistin Concentrations and Risk of New Onset Heart Failure in Older Persons: The Health, Aging, and Body Composition (Health ABC) Study

Objective—Resistin is associated with inflammation and insulin resistance and exerts direct effects on myocardial cells including hypertrophy and altered contraction. We investigated the association of serum resistin concentrations with risk for incident heart failure (HF) in humans. Methods and Results—We studied 2902 older persons without prevalent HF (age, 73.6±2.9 years; 48.1% men; 58.8% white) enrolled in the Health, Aging, and Body Composition (Health ABC) Study. Correlation between baseline serum resistin concentrations (20.3±10.0 ng/mL) and clinical variables, biochemistry panel, markers of inflammation and insulin resistance, adipocytokines, and measures of adiposity was weak (all rho <0.25). During a median follow-up of 9.4 years, 341 participants (11.8%) developed HF. Resistin was strongly associated with risk for incident HF in Cox proportional hazards models controlling for clinical variables, biomarkers, and measures of adiposity (HR, 1.15 per 10.0 ng/mL in adjusted model; 95% CI, 1.05 to 1.27; P=0.003). Results were comparable across sex, race, diabetes mellitus, and prevalent and incident coronary heart disease subgroups. In participants with available left ventricular ejection fraction at HF diagnosis (265 of 341; 77.7%), association of resistin with HF risk was comparable for cases with reduced versus preserved ejection fraction. Conclusions—Serum resistin concentrations are independently associated with risk for incident HF in older persons.
Single-Phase Inverter Drive for Interior Permanent Magnet Machines

This paper proposes a novel drive method for interior permanent magnet machines (IPMMs). In the proposed system, a two-phase IPMM is fed from a single-phase H-bridge inverter for low-cost applications. Its main winding in d -axis is connected to the inverter and the auxiliary winding in q-axis is inherently short circuited. This configuration enables the motor to operate in a wider speed range with higher energy efficiency than most other single-phase drive systems. Also, its torque capability in the high-speed range is as high as that of the three-phase IPMM drive despite the reduced power devices, drivers, and current sensors. Accordingly, the proposed system has benefits such as simple structure, low cost, high-power density, and improved efficiency. In this paper, the system is modeled with an equivalent three-phase machine. Based on the model, its torque characteristics and operating areas are analyzed and compared to those of the conventional IPMM drives. A speed control algorithm is also developed. It includes a maximum torque per ampere control to improve drive efficiency and a flux-weakening control to maximize the feasible inverter output voltage. The proposed system and control algorithm are verified by experimental results.
Early impairment of skeletal muscle endothelial glycocalyx barrier properties in diet‐induced obesity in mice

While previous studies have indicated an important role for the endothelial glycocalyx in regulation of microvascular function, it was recently shown that acute enzymatic glycocalyx degradation in rats was associated with an impaired insulin‐mediated glucose disposal. The aim of this study was to determine whether glycocalyx damage in skeletal muscle occurs at an early stage of diet‐induced obesity (DIO). The microcirculation of the hindlimb muscle of anesthetized C57Bl/6 mice, fed chow (CON) or a high‐fat diet (HFD) for 6 and 18 weeks (w), respectively, was visualized with a Sidestream Dark‐Field camera, and glycocalyx barrier properties were derived from the calculated perfused boundary region (PBR). Subsequently, an intraperitoneal glucose tolerance test was performed and the area under the curve (AUC) of blood glucose was calculated. Impairment of glycocalyx barrier properties was already apparent after 6 weeks of HFD and remained after 18 weeks of HFD (PBR [in μm]: 0.81 ± 0.03 in CON_6w vs. 0.97 ± 0.04 in HFD_6w and 1.02 ± 0.07 in HFD_18w [both P < 0.05]). Glucose intolerance appeared to develop more slowly (AUC [in mmol/L × 120 min]: 989 ± 61 in CON_6w vs. 1204 ± 89 in HFD_6w [P = 0.11] and 1468 ± 84 in HFD_18w [P < 0.05]) than the impairment of glycocalyx barrier properties. The data indicate that damage to the endothelial glycocalyx is an early event in DIO. It is suggested that glycocalyx damage may contribute to the development of insulin resistance in obesity.
A VSV‐G Pseudotyped HIV Vector Mediates Efficient Transduction of Human Pulmonary Artery Smooth Muscle Cells

Attempts were made to infect human vascular smooth muscle cells derived from the pulmonary artery (hPASMC) with two different human immunodeficiency virus (HIV) vector systems. ADA/Luc or HXB2/Luc were generated by cotransfection of luciferase reporter gene vector, pNL4‐3‐Lue‐E–R–, and one of two envelope expressing vectors, pSMADA (R5) or pSMHXB2 (X4). The VSV‐G/Luc or VSV‐G/GFP were produced by a three‐plasmid expression system which consisted of vesicular stomatitis virus G protein (VSV‐G) expressing vector, packaging plasmid, and one of two reporter genes (pHR'‐CMV‐Luc or pHR'‐CMV‐GFP). We used hPASMC, U87.CD4. CCR5 and U87.CD4. CXCR4 for infection. Neither ADA/Luc nor HXB2/Luc could infect hPASMC, though they could infect U87.CD4 with corresponding coreceptors. On the other hand, the transduction of both VSV‐G/Luc and VSV‐G/GFP to hPASMC was remarkable. At day 3, the relative proportion of positive cells of hPASMC infected with VSV‐G/GFP was 15%. The above finding indicates a direct role of HIV‐1 infection in pulmonary hypertension ‘a rare complication of HIV‐1 infection’ and HIV‐based vectors could introduce foreign genes into hPASMC for gene therapy of pulmonary hypertension.
SPACECRAFT COORDINATION CONTROL USING PID+ BACKSTEPPING

Abstract In this paper we present a PID+ solution to the problem of relative translational and rotational tracking, using the concept of integrator backstepping. By using an integrator augmentation technique, we include integral effect in the controller to account for the unknown orbital perturbations. The controller solution utilizes the quaternion representation to achieve a shorter rotation path on commanded attitude changes, and the equilibrium points in the closed-loop system are proved to be uniformly exponentially stable. Finally, simulation results are presented to show the controller performance.
Software Watermarking Algorithm by Coefficients of Equation

Aiming at speed of the program and capacity of hidden information in traditional algorithms as equation reordering, a new algorithm based on inverse number of equation’s operand coefficient was proposed in this paper. Through the one-to-one relationship between the inverse number and the binary number we can get the Dictionary Mapping. According to the Dictionary Mapping, which is made up of the inverse number of permutation and the binary number, we hide the watermark data. The main advantages of this method are that no code is added to the program and speed of the program is not changed, but the efficiency of hidden data is effectively improved. The capability of this new software watermarking algorithm is better than those of algorithms as equation reordering.
Why Does Brain Damage Impair Memory? A Connectionist Model of Object Recognition Memory in Perirhinal Cortex

Object recognition is the canonical test of declarative memory, the type of memory putatively impaired after damage to the temporal lobes. Studies of object recognition memory have helped elucidate the anatomical structures involved in declarative memory, indicating a critical role for perirhinal cortex. We offer a mechanistic account of the effects of perirhinal cortex damage on object recognition memory, based on the assumption that perirhinal cortex stores representations of the conjunctions of visual features possessed by complex objects. Such representations are proposed to play an important role in memory when it is difficult to solve a task using representations of only individual visual features of stimuli, thought to be stored in regions of the ventral visual stream caudal to perirhinal cortex. The account is instantiated in a connectionist model, in which development of object representations with visual experience provides a mechanism for judgment of previous occurrence. We present simulations addressing the following empirical findings: (1) that impairments after damage to perirhinal cortex (modeled by removing the “perirhinal cortex” layer of the network) are exacerbated by lengthening the delay between presentation of to-be-remembered items and test, (2) that such impairments are also exacerbated by lengthening the list of to-be-remembered items, and (3) that impairments are revealed only when stimuli are trial unique rather than repeatedly presented. This study shows that it may be possible to account for object recognition impairments after damage to perirhinal cortex within a hierarchical, representational framework, in which complex conjunctive representations in perirhinal cortex play a critical role.
Motion segmentation and scene classification from 3D LIDAR data

We propose a hierarchical data segmentation method from a 3D high-definition LIDAR laser scanner for cognitive scene analysis in context of outdoor vehicles. The proposed system abstracts the raw information from a parallel laser system (velodyne system). It extracts essential information about drivable road segments in the vicinity of the vehicle and clusters the surrounding scene into point clouds representing static and dynamic objects which can attract the attention of the mission planning system. The system is validated on real data acquired from our experimental vehicle in urban, highway and cross-country scenarios.
Speech recognition in multiple languages and domains: the 2003 BBN/LIMSI EARS system

We report on the results of the first evaluations for the BBN/LIMSI system under the new DARPA EARS program. The evaluations were carried out for conversational telephone speech (CTS) and broadcast news (BN) for three languages: English, Mandarin, and Arabic. In addition to providing system descriptions and evaluation results, the paper highlights methods that worked well across the two domains and those few that worked well on one domain but not the other. For the BN evaluations, which had to be run under 10 times real-time, we demonstrated that a joint BBN/LIMSI system with a time constraint achieved better results than either system alone.
Weakly-Supervised Recognition, Localization, and Explanation of Visual Entities

To learn from visual collections, manual annotations are required. Humans however can no longer keep up with providing strong and time consuming annotations on the ever increasing wealth of visual data. As a result, approaches are required that can learn from fast and weak forms of annotations in visual data. This doctorial symposium summarizes my ongoing PhD dissertation on how to utilize weakly-supervised annotations to recognize, localize, and explain visual entities in images and videos. In this context, visual entities denote objects, scenes, and actions (in images), and actions and events (in videos). The summary is performed through four publications. For each publication, we discuss the current state-of-the-art, as well as our proposed novelties and performed experiments. The end of the summary discusses several possibilities to extend the dissertation.
Geodynamics of the Lomonosov Ridge in the Central Arctic

The deep-water basin on the Lomonosov Ridge in Central Arctic was rapidly formed on a shallow water shelf in the early Miocene. The continuity of the main seismic reflectors in the sedimentary cover of the ridge indicates no significant crustal stretching during the subsidence. The absence of large free-air gravity anomalies above the ridge precludes the dynamic topography in the mantle from being a cause of the formation of the basin. In the Miocene, the ridge was very far from the convergent boundaries therefore lithospheric flexing is unlikely to produce the subsidence. Under these conditions, crustal subsidence on the ridge was most probably associated with the increase in the crustal density due to metamorphic reactions catalyzed by fluid infiltration from the mantle.
Challenges in Audit Testing of Web Services

Audit testing of Web services is a form of regression testing that applies to the integration of external services in a service composition. When such services change, the application that integrates them needs to be regressiontested, to ensure that the existing functionalities are not broken by the service changes. This means the external services must be audited for preserved compatibility with the integration. In this paper, we analyze the main research challenges behind audit testing of services. Such challenges descend from the limited testability of external services and encompass traditional regression testing problems, such as test case selection and prioritization, for which existing solutions are nonetheless inadequate. Moreover, in the paper we discuss in detail one such challenge, i.e., the problem of defining an oracle by making the integrator's assumptions explicit.
Design and evaluation of Rheumatoid Arthritis rehabilitative Device (RARD) for laterally bent fingers

This paper presents the design and evaluation of a soft-robotic exoskeleton, RARD, for the rehabilitation of arthritis affected individuals with laterally deformed fingers due to Heberden's nodes and Bouchard's nodes. The exoskeleton operates using two 3D-printed soft pneumatic elastomeric actuators that are flexible to conform to the curvature of the deformity when not pressurized. Upon pressurization, the actuators can generate sufficient force to overcome the stiffness of the deformed fingers to realign them straight, allowing for progressive rehabilitation. Experimental study was performed on the designed pneumatic actuators to characterize its maximum bending force output from the pressure input. Additionally, the effectiveness of the exoskeleton was evaluated using a human mannequin hand with the simulated deformity. The soft-robotic exoskeleton has been demonstrated to be a promising rehabilitative device for treating laterally deformed digits on the hands.
Scalable Fault-Tolerant Data Feeds in AsterixDB

In this paper we describe the support for data feed ingestion in AsterixDB, an open-source Big Data Management System (BDMS) that provides a platform for storage and analysis of large volumes of semi-structured data. Data feeds are a mechanism for having continuous data arrive into a BDMS from external sources and incrementally populate a persisted dataset and associated indexes. The need to persist and index "fast-flowing" high-velocity data (and support ad hoc analytical queries) is ubiquitous. However, the state of the art today involves 'gluing' together different systems. AsterixDB is different in being a unified system with "native support" for data feed ingestion. We discuss the challenges and present the design and implementation of the concepts involved in modeling and managing data feeds in AsterixDB. AsterixDB allows the runtime behavior, allocation of resources and the offered degree of robustness to be customized to suit the high-level application(s) that wish to consume the ingested data. Initial experiments that evaluate scalability and fault-tolerance of AsterixDB data feeds facility are reported.