Miracle-dz/UniFAR-FTUs huggingface dataset:
Evaluation of Genetic Diversity of Wheat (Triticum aestivum) Lines Under Terminal Heat Stress in the Hisar Environment

Various environmental stresses affect plant development and growth globally and restrict agricultural output and productivity. Wheat plants are negatively impacted by terminal heat stress, which lowers productivity. The correlation between grain yield and other qualities may determine the plant material's ability to minimize the effects of heat stress on yield, and a trait variance aids in the identification of attractive genotypes in a breeding program. To accomplish this, the genetic variability, heritability, correlation and path coefficient analyses of 64 bread wheat genotypes were conducted. As a result, all 15 morpho-physiological traits revealed highly significant genotypic variations. Total chlorophyll content and main spike weight were both higher than 42% and 16%, respectively, for the genotypic coefficient of variation and the phenotypic coefficient of variation. The grain yield per plot indicated a significant and positive correlation with spike length, spike weight, number of grains per spike, number of spikelets per spike, 1000-grain weight, biological yield per plot, grain growth rate, total chlorophyll content and number of productive tillers per meter. As a result, five genotypes, P13833, P13828, P13031, P13723, and P13726, had higher yields and should be utilized as parents in breeding programs. The results revealed that the selection of key physiological and morphological characteristics associated with grain production significantly raises wheat productivity in situations like heat stress.
Technology Acceptance among English Pre-service Teachers: A Path Analysis Approach

Incorporating technology in English language teaching practices has the potential to generate more lively and captivating learning experiences for learners. The challenge lies in adequately equipping pre-service English language teachers with the skills to seamlessly incorporate technology in their teaching methods and improve students' academic performance, despite their favorable perception of its usefulness. The study aimed to shed light on the factors that contribute to pre-service teachers' acceptance of technology and to determine the applicability of the Technology Acceptance Model in the context of English language Teaching (ELT). For this study, the framework developed by Teo (2009) was utilized. The participants were 286 English pre-service teachers. The study identified 21 pairs of factors that positively and significantly affect technology acceptance, with Perceived Usefulness having the highest correlation coefficient and Facilitating Conditions having the lowest. The path analysis of the technology acceptance model revealed that while the model was a good fit for this study, there were two non-significant paths. Perceived Ease of Use and Perceived Usefulness were found to directly affect technology acceptance, while Technological Complexity and Facilitating Conditions had indirect effects through Perceived Ease of Use and Perceived Usefulness. The results of this study showed that interventions to improve technology acceptance amongst pre-service teachers should take into account direct and indirect factors.
Cyanobacteria as a potential bioasset for restoring degraded land

Degradation and pollution of land resources is a severe issue worldwide. Rapid urbanization and increased food demand have necessitated the restoration of degraded and highly contaminated land resources in a sustainable manner. The role of soil microorganism in maintaining nutrient balance, texture, fertility, and soil health is widely acknowledged. Cyanobacteria, one of the major components of soil microbiota, have been explored for their role as biofertilizers in improving plant growth and increasing soil fertility; however, less attention has been paid to their potential in restoring degraded lands. Cyanobacteria aids in nutrient cycling, production of plant growth‐promoting substances, desalination, and degradation of diverse organic as well as inorganic contaminants. They use diverse mechanisms for bioremediation (such as biosorption, bioaccumulation, and biotransformation) of contaminants in addition to the specific mechanism employed. They occur in symbiotic relationships with various hosts in natural as well as anthropogenically disturbed environments. Therefore, their use in restoration of highly degraded lands is justified and needs to be recognized worldwide. Identifying and exploring cyanobacterial species thriving in stress conditions and multiomics approaches would help in reconnoitering the complex plant–soil‐cyanobacteria interactions and enable scientists to design robust and well‐integrated biotechnological tools for soil remediation. Nevertheless, several technical challenges need to be addressed for rendering cyanobacteria as a realistic and viable bioasset. In this article, we summarize the role of cyanobacteria in addressing the reclamation of various types of degraded and polluted soils. And, it also examines the remaining knowledge gaps that limit its applicability in diverse environmental settings in a sustainable manner.
ASSESSMENT OF RISK FACTORS FOR SURGERY TREATMENT OF CROHN’S DISEASE: A HOSPITAL COHORT

ABSTRACT BACKGROUND New therapies have revolutionized the treatment of Crohn’s disease (CD), but in some countries, the surgery rate has not changed, the frequency of emergency surgery is underestimated, and surgical risk is poorly studied. AIMS: The aim of this study was to identify risk factors and clinical indications for primary surgery in CD patients at the tertiary hospital. METHODS: This was a retrospective cohort of a prospectively collected database of 107 patients with CD from 2015 to 2021. The main outcomes were the incidence of surgery treatment, types of procedures performed, surgical recurrence, surgery free time, and risk factors for surgery. RESULTS: Surgical intervention was performed in 54.2% of the patients, and most of the procedures were emergency surgeries (68.9%). The elective procedures (31.1%) were performed over 11 years after diagnosis. The main indications for surgery were ileal stricture (34.5%) and anorectal fistulas (20.7%). The most frequent procedure was enterectomy (24.1%). Recurrence surgery was most common in emergency procedures (OR 2.1; 95%CI 1.6–6.6). Montreal phenotype L1 stricture behavior (RR 1.3; 95%CI 1.0–1.8, p=0.04) and perianal disease (RR 1.43; 95%CI 1.2–1.7) increased the risk of emergency surgeries. The multiple linear regression showed age at diagnosis as a risk factor for surgery (p=0.004). The study of surgery free time showed no difference in the Kaplan-Meier curve for Montreal classification (p=0.73). CONCLUSIONS: The risk factors for operative intervention were strictures in ileal and jejunal diseases, age at diagnosis, perianal disease, and emergency indications.
Revealing the Mechanism of the Bias Temperature Instability Effect of p-GaN Gate HEMTs by Time-Dependent Gate Breakdown Stress and Fast Sweeping Characterization

The bias temperature instability (BTI) effect of p-GaN gate high-electron-mobility transistors (HEMTs) is a serious problem for reliability. To uncover the essential cause of this effect, in this paper, we precisely monitored the shifting process of the threshold voltage (VTH) of HEMTs under BTI stress by fast sweeping characterizations. The HEMTs without time-dependent gate breakdown (TDGB) stress featured a high VTH shift of 0.62 V. In contrast, the HEMT that underwent 424 s of TDGB stress clearly saw a limited VTH shift of 0.16 V. The mechanism is that the TDGB stress can induce a Schottky barrier lowering effect on the metal/p-GaN junction, thus boosting the hole injection from the gate metal to the p-GaN layer. This hole injection eventually improves the VTH stability by replenishing the holes lost under BTI stress. It is the first time that we experimentally proved that the BTI effect of p-GaN gate HEMTs was directly dominated by the gate Schottky barrier that impeded the hole supply to the p-GaN layer.
An Examination Of The Effectiveness Of The Adomian Decomposition Method In Fluid Dynamic Applications

Since its introduction in the 1980s, the Adomian Decomposition Method (ADM) has proven to be an efficient and reliable method for solving many types of problems. Originally developed to solve nonlinear functional equations, the ADM has since been used for a wide range of equation types (like boundary value problems, integral equations, equations arising in flow of incompressible and compressible fluids etc.). This work is devoted to an evaluation of the effectiveness of this method when used for fluid dynamic applications. In particular, the ADM has been applied to the Blasius equation, the Falkner-Skan equation, and the OrrSommerfeld equation. This study is divided into five Chapters and an Appendix. The first chapter is devoted to an introduction of the Adomian Decomposition method (ADM) with simple illustrations. The Second Chapter is devoted to the application of the ADM to generalized Blasius Equation and our result is compared to other published results when the parameter values are appropriately set. Chapter 3 presents the solution generated for the Falkner-Skan equation. Finally, the Orr-Sommerfeld equation is dealt with in the fourth Chapter. Chapter 5 is devoted to the findings and recommendations based on this study. The Appendix contains details of the solutions considered as well as an alternate solution for the generalized Blasius Equation using Bender’s δ-perturbation method.
A Lattice Boltzmann Model for Oscillating Reaction–Diffusion

Abstract A computational algorithm based on the lattice Boltzmann method (LBM) is proposed to model reaction–diffusion systems. In this paper, we focus on how nonlinear chemical oscillators like Belousov–Zhabotinsky (BZ) and the chlorite–iodide–malonic acid (CIMA) reactions can be modeled by LBM and provide with new insight into the nature and applications of oscillating reactions. We use Gaussian pulse initial concentrations of sulfuric acid in different places of a bidimensional reactor and nondiffusive boundary walls. We clearly show how these systems evolve to a chaotic attractor and produce specific pattern images that are portrayed in the reactions trajectory to the corresponding chaotic attractor and can be used in robotic control.
Identification of Torquetenovirus Species in Patients with Kawasaki Disease Using a Newly Developed Species-Specific PCR Method

A next-generation sequencing (NGS) study identified a very high viral load of Torquetenovirus (TTV) in KD patients. We aimed to evaluate the feasibility of a newly developed quantitative species-specific TTV-PCR (ssTTV-PCR) method to identify the etiology of KD. We applied ssTTV-PCR to samples collected from 11 KD patients and 22 matched control subjects who participated in our previous prospective study. We used the NGS dataset from the previous study to validate ssTTV-PCR. The TTV loads in whole blood and nasopharyngeal aspirates correlated highly (Spearman’s R = 0.8931, p < 0.0001, n = 33), supporting the validity of ssTTV-PCR. The ssTTV-PCR and NGS results were largely consistent. However, inconsistencies occurred when ssTTV-PCR was more sensitive than NGS, when the PCR primer sequences mismatched the viral sequences in the participants, and when the NGS quality score was low. Interpretation of NGS requires complex procedures. ssTTV-PCR is more sensitive than NGS but may fail to detect a fast-evolving TTV species. It would be prudent to update primer sets using NGS data. With this precaution, ssTTV-PCR can be used reliably in a future large-scale etiological study for KD.
The Benefit of a Retrospective Pregnancy Anamnesis in Child and Adolescent Psychiatry: The Reliability of Maternal Self-Report during Childhood Development

Pregnancy anamnesis is a crucial part of child and adolescent psychiatry diagnostics. In previous works, the reliability of retrospective maternal self-report on perinatal characteristics was heterogeneous. This prospective longitudinal study aimed to evaluate women’s recall of prenatal events in a within-subject design. A sample of 241 women gave a self-report on prenatal alcohol, smoking, partnership quality, pregnancy satisfaction, and obstetric complications during the 3rd trimester (t0), childhood (t1, 6–10 y), and adolescence (t2, 12–14 y). The intra-individual agreement was examined. The t0–t1–(t2) agreement was poor to substantial; this was highest for smoking and worst for obstetric complications, followed by alcohol (Fleiss’ κ = 0.719 to −0.051). There were significant t0–t1–(t2) differences for all pregnancy variables (p < 0.017), except for 3rd trimester satisfaction (p = 0.256). For alcohol (t0 25.8%, t1 17.4%, t2 41.0%) and smoking (t0 11.9%, t1 16.4%, t2 22.6%), the highest self-reported rates were found during adolescence. During childhood, fewer obstetric complications (t0 84.9%, t1 42.2%) and worse partnerships were reported (t0 M = 8.86, t1 M = 7.89). Thought to be due to social stigmata and memory effects, pregnancy self-reports cannot be precisely reproduced. Creating a respectful and trusting atmosphere is essential for mothers to give honest self-reports that are in the best interest of their children.
Testing the Impact of Social Isolation on Students' Acceptance of Learning Management Systems After the COVID-19 Crisis Using a Modified UTAUT Model

After more than two years of the beginning of Covid-19 crisis, this research work investigates the students' acceptance towards utilizing learning management systems (LMSs) as a useful supporting learning medium while most of higher education institutions over the world have adopted these systems to become an indispensable, promising teaching tool and considering the distance learning as compliance to the conditions of social isolation is case of any crisis. This article analyzes the most significant factors effecting the adoption and led to the acceptance of LMSs through the higher education across 423 undergraduate and postgraduate students from several universities in Jordan. By applying the structural equation modelling, the results reveal that all proposed determinants have an impact on the adoption of distance learning, with noted significant impact for social isolation. The infection anxiety and students' level have moderated these effects on the behavioral intentions and actual use of learning management systems and show significant impact on them.
Pulsatile Subcutaneous Hydrocortisone Replacement in Primary Adrenal Insufficiency

Abstract Pulsatile endogenous cortisol secretion is critical for physiological glucocorticoid gene signaling. Conventional glucocorticoid replacement therapy does not mimic endogenous cortisol pulsing in primary adrenal insufficiency. In an open-labeled, two-week, nonrandomized cross-over study of five patients with adrenal insufficiency (Addison’s disease in two, bilateral adrenalectomy in one, and congenital adrenal hyperplasia in two patients) we compared pulsatile and continuous cortisol pump treatment and conventional oral glucocorticoid therapy with respect to 24-h serum corticosteroid levels and plasma adrenocorticotropic hormone (ACTH). Pulsed pump restored ultradian rhythmicity as demonstrated by five peaks of serum (all patients) and subcutaneous tissue cortisol (four patients). Morning subcutaneous cortisol and cortisone were higher in continuous and pulsed pump treatment than in oral therapy despite nearly similar serum cortisol levels in all treatment arms. ACTH was within the physiological range during pulsed pump treatment in all patients except for slightly elevated levels in the morning hours 04:00–08:00 h. During oral therapy, ACTH was very high in patients with Addison’s disease and suppressed in patients with congenital adrenal hyperplasia. In conclusions, mimicking endogenous cortisol rhythmicity by ultradian subcutaneous infusion of cortisol is feasible. It was superior to both continuous pump and oral therapy in maintaining normal ACTH levels throughout the 24-h cycle. Our results demonstrate a low free cortisol bioavailability on thrice daily oral replacement therapy compared to both types of subcutaneous infusion.
Quo Vadis Brand Love? Role of Cognition-Affection-Behavior Model for Local Coffee Shops in Indonesia

This study aims to identify the structural relationship between image, experience, love, trust, and brand loyalty for branded local coffee shops using the cognitive-affective-behavior (C-AB) model. One hundred thirty-five respondents participated in this study, and data analysis was performed using the SmartPLS statistical tool with the PLS-SEM method. It was found that brand image and experience had a significantly positive relationship with brand love and trust. Brand love and brand trust also have a significant positive relationship with brand loyalty, according to the assessment of Indonesian people on their favorite local coffee shop brands. This study contributes to the literature that the C-A-B model can explain the factors that form brand loyalty in the local coffee shop industry. In practice, brand love and brand trust owned by local communities form brand loyalty relationships in local products. This study also shows the mediating effect of brand love and brand trust for branded local coffee shops. Brand Love indirectly mediates the relationship between Brand Image and Brand Loyalty, but Brand Trust does not directly mediate the relationship between Brand Experience and Brand Loyalty. This study's main limitation is using the brand love mark only for brand love. The dimension of the brand love mark as Brand Respect can be included in future research.
Compromised Myelin and Axonal Molecular Organization Following Adult-Onset Sulfatide Depletion

3-O-sulfogalactosylceramide, or sulfatide, is a prominent myelin glycosphingolipid reduced in the normal appearing white matter (NAWM) in Multiple Sclerosis (MS), indicating that sulfatide reduction precedes demyelination. Using a mouse model that is constitutively depleted of sulfatide, we previously demonstrated that sulfatide is essential during development for the establishment and maintenance of myelin and axonal integrity and for the stable tethering of certain myelin proteins in the sheath. Here, using an adult-onset depletion model of sulfatide, we employ a combination of ultrastructural, immunohistochemical and biochemical approaches to analyze the consequence of sulfatide depletion from the adult CNS. Our findings show a progressive loss of axonal protein domain organization, which is accompanied by axonal degeneration, with myelin sparing. Similar to our previous work, we also observe differential myelin protein anchoring stabilities that are both sulfatide dependent and independent. Most notably, stable anchoring of neurofascin155, a myelin paranodal protein that binds the axonal paranodal complex of contactin/Caspr1, requires sulfatide. Together, our findings show that adult-onset sulfatide depletion, independent of demyelination, is sufficient to trigger progressive axonal degeneration. Although the pathologic mechanism is unknown, we propose that sulfatide is required for maintaining myelin organization and subsequent myelin–axon interactions and disruptions in these interactions results in compromised axon structure and function.
Effect of Whitening Toothpastes with Different Active Agents on the Abrasive Wear of Dentin Following Tooth Brushing Simulation

The aim of this research was to evaluate the abrasive dentin wear that can be induced by three commercial whitening toothpastes following a tooth-brushing simulation (TBS) corresponding to a three-month period. Sixty human canines were selected, and the roots were separated from the crowns. Then the roots were randomly divided into six groups (n = 10) and were submitted to TBS using the following slurries: Group 1—deionized water (RDA = 5); Group 2—ISO dentifrice slurry (RDA = 100); Group 3—a regular toothpaste (RDA = 70); Group 4—a charcoal-containing whitening toothpaste; Group 5—a whitening toothpaste containing blue covasorb and hydrated silica; and Group 6—a whitening toothpaste containing microsilica. Following TBS, surface loss and surface roughness changes were evaluated using confocal microscopy. Additionally, surface morphology and mineral content changes were observed using scanning electron microscopy and energy-dispersive X-ray spectroscopy. The deionized water group presented the lowest surface loss (p < 0.05), while the charcoal-containing toothpaste presented the highest surface loss, followed by ISO dentifrice slurry (p < 0.001). Blue-covasorb-containing and regular toothpastes did not present statistically significant differences (p = 0.245), and neither didmicrosilica-containing toothpaste or ISO dentifrice slurry (p = 0.112). The surface height parameters and surface morphology changes of the experimental groups followed the surface loss patterns, while no differences were detected in mineral content after TBS.Although the charcoal-containing toothpaste exhibited the highest abrasive wear to dentin, according to ISO 11609, all the tested toothpastes exhibited appropriate abrasive behavior towards dentin.
9-O Acetylated Gangliosides in Health and Disease

Glycosphingolipids comprise a lipid class characterized by the presence of sugar moieties attached to a ceramide backbone. The role of glycosphingolipids in pathophysiology has gained relevance in recent years in parallel with the development of analytical technologies. Within this vast family of molecules, gangliosides modified by acetylation represent a minority. Described for the first time in the 1980s, their relation to pathologies has resulted in increased interest in their function in normal and diseased cells. This review presents the state of the art on 9-O acetylated gangliosides and their link to cellular disorders.
SURVEY AND SUMMARY Regulated functional alternative splicing in Drosophila

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Individual/Peak Gamma Frequency: What Do We Know?

In recent years, the concept of individualized measures of electroencephalographic (EEG) activity has emerged. Gamma-band activity plays an important role in many sensory and cognitive processes. Thus, peak frequency in the gamma range has received considerable attention. However, peak or individual gamma frequency (IGF) is rarely used as a primary measure of interest; consequently, little is known about its nature and functional significance. With this review, we attempt to comprehensively overview available information on the functional properties of peak gamma frequency, addressing its relationship with certain processes and/or modulation by various factors. Here, we show that IGFs seem to be related to various endogenous and exogenous factors. Broad functional aspects that are related to IGF might point to the differences in underlying mechanisms. Therefore, research utilizing different types of stimulation for IGF estimation and covering several functional aspects in the same population is required. Moreover, IGFs span a wide range of frequencies (30–100 Hz). This could be partly due to the variability of methods used to extract the measures of IGF. In order to overcome this issue, further studies aiming at the optimization of IGF extraction would be greatly beneficial.