Miracle-dz/UniFAR-FTUs huggingface dataset:
Comparing power hitting kinematics between skilled male and female cricket batters

ABSTRACT Organismic, task, and environmental constraints are known to differ between skilled male and female cricket batters during power hitting tasks. Despite these influences, the techniques used in such tasks have only been investigated in male cricket batters. This study compared power hitting kinematics between 15 male and 15 female batters ranging from university to international standard. General linear models were used to assess the effect of gender on kinematic parameters describing technique, with height and body mass as covariates. Male batters generated greater maximum bat speeds, ball launch speeds, and ball carry distances than female batters on average. Male batters had greater pelvis-thorax separation in the transverse plane at the commencement of the downswing (β = 1.14; p = 0.030) and extended their lead elbows more during the downswing (β = 1.28; p = 0.008) compared to female batters. The hypothesised effect of gender on the magnitude of wrist uncocking during the downswing was not observed (β = −0.14; p = 0.819). The causes of these differences are likely to be multi-factorial, involving aspects relating to the individual players, their history of training experiences and coaching practices, and the task of power hitting in male or female cricket.
Supporting Employee Health at Work: How Perceptions Differ Across Wage Category

Purpose: This study examines the association between sources of stress and perceptions of organizational and supervisor support for health and well-being. Design: Retrospective, cross-sectional analysis. Setting: Large university in the mid-western United States. Sample: This study focused on university employees with complete data for all variables (organizational support/N = 19,536; supervisor support/N = 20,287). Measures: 2019 socioeconomic and demographic characteristics, count of chronic conditions, sources of stress and perceptions of organizational and supervisor support. Analysis: For the multivariate analyzes, linear regression models were analyzed separately by wage bands (low ≤$46,100; middle >$46,100-$62,800; high >$62,800). Results: For all employees, workplace stressors, including problematic relationships at work and heavy job responsibilities, were negatively associated with perceptions of supervisor and organizational support. In comparison, the most salient home-based stressors were negatively associated with perceptions of supervisor support for the lowest-wage band (the death of a loved one, b = −0.13) and middle-wage band (personal illness or injury, b = −0.09), while the one for the highest-wage band (illness or injury of a loved one, b = 0.07) was positively associated with perceptions of supervisor support. Conclusion: Stressful job responsibilities and work relationships are associated with lower perceptions of supervisor and organizational support for health and well-being across all wage bands. Favorable perceived support for personal stressors only among high wage earning employees may suggest a need for improved equity of perceived support for these stressors among lower wage workers.
Pathogenesis of Equid Alphaherpesvirus 1 Infection in the Central Nervous System of Mice

Equid alphaherpesvirus 1 (EHV-1) causes myeloencephalopathy in horses and occasionally in non-equid species. Although mouse models have been developed to understand EHV-1 pathogenesis, few EHV-1 strains have been identified as highly neurovirulent to mice. The aim of this study was to evaluate the pathogenesis of 2 neurovirulent EHV-1 strains in mice, and to characterize the inflammatory cells and expression of chemokines and the apoptosis marker caspase-3 in the brain of infected mice. C57BL/6J mice were inoculated intranasally with EHV-1 strains A4/72 or A9/92 and evaluated on 1, 2, and 3 days post inoculation (DPI). EHV-1-infected mice showed severe neurological signs at 3 DPI. Ultrastructural analysis revealed numerous viral nucleocapsids and fewer enveloped virions within degenerated and necrotic neurons and in the surrounding neuropil. Histologically, at 3 DPI, there was severe diffuse neuronal degeneration and liquefactive necrosis, prominent microgliosis, and perivascular cuffing composed of CD3+ cells (T cells) and Iba-1+ cells (macrophages), mainly in the olfactory bulb and ventral portions of the brain. In these areas, moderate numbers of neuroglial cells expressed CCL5 and CCL2 chemokines. Numerous neurons, including those in less affected areas, were immunolabeled for cleaved caspase-3. In conclusion, neurovirulent EHV-1 strains induced a fulminant necrotizing lymphohistiocytic meningoencephalitis in mice, with microgliosis and expression of chemokines and caspase-3. This model will be useful for understanding the mechanisms underlying the extensive neuropathology induced by these viral infections.
Joint effects of children’s emotional problems and parental depressive symptoms on the occurrence of internet gaming disorder among children and adolescents: A longitudinal study

Abstract Background and aims Parental depressive symptoms may aggravate the effects of children’s emotional problems on risks for Internet gaming disorder (IGD). Here we examined the joint effects of children’s emotional problems and parents’ depressive symptoms on the incidence of IGD. Methods A large prospective, population-based cohort tested potential interactions between children’s emotional problems, parents’ depressive symptoms, and incidence of high risk of IGD (HRIGD). Family dyads (n=2,031) that included children who were non-HRIGD at baseline completed assessments of childhood and parental affective symptomatology. HRIGD was assessed at baseline and 12 months. Relative excess risk due to interaction (RERI) estimated the magnitudes of interactions. Results In terms of risk for the development of IGD, parental depression was 1.8 times greater, children’s emotional problems were 2.9 times greater, and both risk factors together were 6.1 times greater than the background risk, with the last two findings reaching statistical significance. The expected risk for the development of HRIGD was RR=3.7. Discussion and conclusions Children’s emotional problems demonstrated a particularly strong relationship with HRIGD. Joint effects of children’s emotional problems and depressive symptoms in parents on the incidence of HRIGD were stronger than the sum of the independent effects of each factor. The findings suggest that combining interventions for the treatment of children’s emotional problems and parents’ depressive symptoms may have extra risk reduction effects on preventing IGD in children and adolescents.
Dimensions of relationship adjustment as correlates of depressive and anxiety symptoms among individuals with chronic pain

ABSTRACT Research suggests that partner relationship quality influences the psychological well-being of individuals with chronic pain, but the specific components of the relationship involved remain understudied. This study examined which dimensions of relationship adjustment influence the depressive and anxiety symptoms reported by the partner with chronic pain. A community sample of 214 adults in a romantic relationship for at least a year were recruited. Participants completed online questionnaires assessing pain characteristics (pain duration, pain intensity), relationship characteristics (marital status, duration of relationship), quality of relationship (dyadic adjustment, conjugal support) and emotional state (symptoms of depression and anxiety). Overall, participants reported well-adjusted relationships with their partners and higher levels of dyadic adjustment and conjugal support were associated with reduced symptoms of depression and anxiety. Most importantly, dyadic consensus, marital status, and pain intensity revealed to be predictive of depressive symptoms, whereas dyadic consensus and pain intensity were predictive of anxiety symptoms. These findings highlight the need to consider the interpersonal functioning of this population to enhance their psychological well-being.
The effects of syringic acid on the properties of MCPA-contaminated soil and the growth of two cucurbit species

Abstract The aim of this study was to determine the influence of syringic acid (SA), a plant secondary metabolite (PSM), on the properties of soil contaminated with 2-methyl-4-chlorophenoxyacetic acid (MCPA) and the condition of two cucurbit species zucchini (C. pepo L. ‘Atena Polka’) and cucumber (C. sativus ‘Cezar’) grown on that soil. It was found that amendment with MCPA and MCPA + SA modified the soil physico-chemical properties. Content of N and K was significantly higher for variants amended with SA and/or MCPA, while P content was lower in variant amended with SA. The cucurbits demonstrated varied efficiencies in mitigating the phytotoxicity of the MCPA-treated soil. For soil amended with MCPA + SA, samples remediated with cucumber were characterized as slightly toxic or toxic (45.2%–81.5%), while those planted with zucchini were nontoxic or slightly toxic (−40.6%−47.8%). Development of cucumber seedlings was fully inhibited by MCPA, regardless of SA application, zucchini demonstrated enhanced growth in soil treated with MCPA + SA and no statistically significant differences between morphological parameters of MCPA + SA-treated zucchini in comparison to control plants were observed. The obtained findings suggest that the application of SA is a promising way to mitigate the toxic influence of MCPA in the soil, depending on the cultivated plant species. Novelty statement: The study meets the criteria of novelty and innovativeness. Most importantly, the study is focused on: phytotoxicity studies to inform about the limitations of phytotechnology based on PSMs. Additionally, this manuscript provides an interdisciplinary description of the effects of MCPA and naturally occurring PSM- SA on cucurbits and soil parameters. Such studies, which combine the interactions between cucurbits, their secondary metabolite (SA) and their role in mitigation of phytotoxicity in MCPA-contaminated soil, has not been performed before.
Differential response of diurnal and nocturnal mammals to prolonged altered light-dark cycle: a possible role of mood associated endocrine, inflammatory and antioxidant system

ABSTRACT The circadian system maintains internal 24 h oscillation of behavior and physiology, and its misalignment with external light-dark (LD) cycle results in negative health outcomes. In order to elucidate the effect of prolonged constant condition and the differences in the response between nocturnal and diurnal species, we studied the effects of constant light (LL) and constant darkness (DD) on a diurnal (squirrel) and a nocturnal (mouse) rodent species, focusing on the endocrine, inflammatory and antioxidant systems associated with depression-like behavior. Squirrels and mice (n = 10/group) were placed in chronocubicle under 12:12 h LD cycle, LL and DD. After 4 weeks, animals were subjected to sucrose preference test and blood and brain tissues were collected for measuring melatonin, corticosterone, proinflammatory cytokine, tumor necrosis factor-α (TNF-α) and the activity of primary antioxidant enzymes, catalase (CAT) and superoxide dismutase (SOD). The results show that in diurnal squirrels, prolonged constant darkness reduced sucrose preference, CAT, and SOD, increased corticosterone and TNF-α levels, but caused no significant change in the melatonin compared to LD condition. In contrast, in nocturnal mice constant darkness caused no significant changes in sucrose preference and corticosterone levels, increased melatonin, CAT and SOD levels but decreased TNF-α levels. Chronic LL caused a similar response in both squirrels and mice: it decreased sucrose preference, melatonin, CAT and SOD levels but increased corticosterone and TNF-α levels. Together, the study demonstrates differential effects of altered light-dark cycle in a diurnal and a nocturnal rodent on interrelated endocrine, inflammatory and antioxidant systems associated with depression-like behavior, with constant light having adverse effects on both species but constant darkness having a negative effect mainly in the diurnal squirrels.
Understanding bariatric patients' experiences of self‐management post‐surgery: A qualitative study

Although most bariatric patients achieve significant weight loss and improvements in both physical and mental health‐related quality of life (HRQoL) in the short‐term, there is wide variability in weight and long‐term HRQoL outcomes. The role of bariatric patients' self‐management style in explaining variability in long‐term outcomes is unclear. This qualitative study examined bariatric patients' self‐management experiences after bariatric surgery in relation to long‐term outcomes. A qualitative study was conducted using semi‐structured individual interviews with post‐surgery patients (n = 23) at a Canadian bariatric surgery program. A constant comparative approach was used to systematically analyse the data and identify overarching themes. Variation in patients' experiences and follow‐up time were the two primary units of analysis. Patients were predominantly female (n = 19; 82.6%) and had a mean age of 50 ± 8.49 years. The median time post‐surgery was 2 years (range: 6 months–7 years). Three distinct phases described the process of self‐management post‐bariatric surgery: (1) rediscovering self‐esteem and confidence in one's ability to self‐manage (1‐month to 1.5‐years post‐surgery), (2) achieving weight maintenance and addressing emotion dysregulation (1.5–3‐years post‐surgery) and (3) embracing a flexible balanced lifestyle (beyond 3‐years). Bariatric surgery patients experience distinct challenges relative to their post‐surgery time course. Facilitating access to interprofessional bariatric care after surgery allowed patients to acquire the self‐management knowledge and skills necessary to address challenges to following the bariatric guidelines in the long‐term.
Efficacy and Safety of Intravenous Lincosamide Therapy in Methicillin-Resistant Staphylococcus aureus Bacteremia

Methicillin-resistant Staphylococcus aureus (MRSA) bacteremia has a high case-fatality rate, but currently recommended antimicrobial therapies have many shortcomings. The efficacy and safety of lincosamide therapy for MRSA bacteremia is incompletely defined. ABSTRACT Methicillin-resistant Staphylococcus aureus (MRSA) bacteremia has a high case-fatality rate, but currently recommended antimicrobial therapies have many shortcomings. The efficacy and safety of lincosamide therapy for MRSA bacteremia is incompletely defined. A retrospective audit was done of the management of all adults with MRSA bacteremia at an Australian tertiary referral hospital between 1 January 2007 and 31 December 2020. A total of 176 patients were included. The case-fatality rate declined from 14/57 (25%) in the first half of the study to 12/119 (10%) in the second half (P = 0.01). Of the 172 patients receiving antibiotics, 62 (36%) received a lincosamide-predominant regimen (lincosamide monotherapy for >50% of the intravenous course). The patients receiving lincosamide-predominant intravenous therapy had lower in-hospital mortality (odds ratio [OR], 0.07; 95% confidence interval [CI], 0.01 to 0.53; P = 0.01) and a lower incidence of renal complications (OR [95% CI], 0.34 [0.15−0.75]; P = 0.008) than patients receiving an alternative regimen. In multivariate analysis that also considered age, disease severity, comorbidity, infectious diseases consultation, source control, and the year of admission, patients receiving a lincosamide-predominant regimen were still less likely to die in the hospital than those receiving an alternative regimen (OR [95% CI], 0.05 [0.00 to 0.65]; P = 0.02). Lincosamides appear to have utility, at least as stepdown therapy, in the treatment of MRSA bacteremia, particularly in young, clinically stable patients with few comorbidities in whom endocarditis has been excluded. Prospective studies will help define their optimal role.
Effects of temperature on the performance of vanadium redox flow battery

Average coulombic efficiency,average energy efficiency,self-discharge and charge-discharge process of single vanadium redox flow cell was assembled and tested under temperature from 25—45 ℃. The mechanism of how temperature affecting the performance of VRB was investigated and discussed.Results showed that the average coulombic efficiency(CE) and average energy efficiency(EE) were reduced from 90.7%(25 ℃) to 87.4%(45 ℃) and from 81.6%(25 ℃) to 78.8%(45 ℃),respectively.At 25 ℃,open circuit voltage(OCV) of the cell during self-discharge process can keep 27 h beyond 0.8 V,while OCV can only keep 16 h beyond 0.8 V at 45 ℃
Human tRNAs with inosine 34 are essential to efficiently translate eukarya-specific low-complexity proteins

Abstract The modification of adenosine to inosine at the wobble position (I34) of tRNA anticodons is an abundant and essential feature of eukaryotic tRNAs. The expansion of inosine-containing tRNAs in eukaryotes followed the transformation of the homodimeric bacterial enzyme TadA, which generates I34 in tRNAArg and tRNALeu, into the heterodimeric eukaryotic enzyme ADAT, which modifies up to eight different tRNAs. The emergence of ADAT and its larger set of substrates, strongly influenced the tRNA composition and codon usage of eukaryotic genomes. However, the selective advantages that drove the expansion of I34-tRNAs remain unknown. Here we investigate the functional relevance of I34-tRNAs in human cells and show that a full complement of these tRNAs is necessary for the translation of low-complexity protein domains enriched in amino acids cognate for I34-tRNAs. The coding sequences for these domains require codons translated by I34-tRNAs, in detriment of synonymous codons that use other tRNAs. I34-tRNA-dependent low-complexity proteins are enriched in functional categories related to cell adhesion, and depletion in I34-tRNAs leads to cellular phenotypes consistent with these roles. We show that the distribution of these low-complexity proteins mirrors the distribution of I34-tRNAs in the phylogenetic tree.
Sequence subtyping of Trichomonas gallinae from Bonelli’s eagle (Aquila fasciata) during four years (2014–2017) reveals that MLS type is associated with lesions

ABSTRACT Avian trichomonosis is a parasitic disease that affects wild birds. The objective of this work was to determine the importance of avian trichomonosis in Bonelli’s eagles to improve conservation measures in this population. One hundred and eighty-eight birds were studied: 181 chicks, two juveniles, one subadult and four adults. The birds were externally examined and gross lesions at the oropharynx registered. Samples from the oropharyngeal cavity were obtained for Trichomonas spp. detection by culture and PCR, and positive samples were subjected to a multilocus sequence typing approach, including the ITS1/5.8S/ITS2 region (ITS), ribosomal RNA small subunit (18S) and Fe-hydrogenase gene (FeHyd). Global prevalence of T. gallinae infection was 37.8% in total, 45.5% in nestlings. Thirty-three percent of the birds developed lesions that ranged from mild (n = 41) to moderate (n = 14) or severe (n = 7). Multilocus sequence typing analysis showed five different MLS types, ITS-A/18S-VI/FeHyd-A1 and ITS-D/18S-II/Fe-C4 being the most frequent. An association between ITS-A/18S-VI/FeHyd-A1 and moderate or severe lesions was observed, but birds with type ITS-A/18S-VI/FeHyd-A2 also developed lesions. On the contrary, birds with MLS type ITS-D/18S-II/FeHyd-C4 displayed only a low proportion of mild lesions. Chicks raised in nests were at higher risk for T. gallinae infection and development of lesions than chicks raised in captivity. Discordances between samples cultured in TYM and samples subjected to PCR from oropharyngeal swabs were observed, swab-ITS-PCR being more sensitive. RESEARCH HIGHLIGHTS 45.5% of Bonelli’s eagles in the nest carried T. gallinae and 39.4% showed lesions. PCR from oral swabs showed higher sensitivity than culture in TYM for detection of T. gallinae. MLS types ITS-A/18S-VI/Fe-A1 (and A2) are a risk factor for the development of lesions.
Machine Learning Model for Predicting Postoperative Survival of Patients with Colorectal Cancer

Purpose Machine learning (ML) is a strong candidate for making accurate predictions, as we can use large amount of data with powerful computational algorithms. We developed a ML based model to predict survival of patients with colorectal cancer (CRC) using data from two independent datasets. Materials and Methods A total of 364,316 and 1,572 CRC patients were included from the Surveillance, Epidemiology, and End Results (SEER) and a Korean dataset, respectively. As SEER combines data from 18 cancer registries, internal validation was done using 18-Fold-Cross-Validation then external validation was performed by testing the trained model on the Korean dataset. Performance was evaluated using area under the receiver operating characteristic curve (AUROC), sensitivity and positive predictive values. Results Clinicopathological characteristics were significantly different between the two datasets and the SEER showed a significant lower 5-year survival rate compared to the Korean dataset (60.1% vs. 75.3%, p < 0.001). The ML-based model using the Light gradient boosting algorithm achieved a better performance in predicting 5-year-survival compared to American Joint Committee on Cancer stage (AUROC, 0.804 vs. 0.736; p < 0.001). The most important features which influenced model performance were age, number of examined lymph nodes, and tumor size. Sensitivity and positive predictive values of predicting 5-year-survival for classes including dead or alive were reported as 68.14%, 77.51% and 49.88%, 88.1% respectively in the validation set. Survival probability can be checked using the web-based survival predictor (http://colorectalcancer.pythonanywhere.com). Conclusion ML-based model achieved a much better performance compared to staging in individualized estimation of survival of patients with CRC.
Effects of Concurrent Tasks on Gait Performance in Children With Traumatic Brain Injury Versus Children With Typical Development

Objective To investigate how gait parameters in children with traumatic brain injury (TBI) versus typically developing (TD) children are influenced by secondary concurrent tasks and examine the correlations between gait parameters and attention and balance in children with TBI. Methods Sixteen children with TBI (mean age, 11.63±1.89 years) and 22 TD controls (mean age, 11.41±2.24 years) participated in this case-control study. Attention and functional balance were measured using the Children’s Color Trail Test (CCTT) and Pediatric Balance Scale (PBS). All participants first walked without concurrent tasks and then with concurrent motor and cognitive tasks. The APDM Mobility Lab was used to measure gait parameters, including gait velocity, stride length, stride duration, cadence, and double support time. Repeated-measures analysis of variance and Spearman correlation coefficient were used for the analysis. Results Children with TBI showed significantly more deterioration in gait performance than TD children (p<0.05). Concurrent tasks (motor and cognitive) significantly decreased gait velocity and cadence and increased stride time; the differences were more obvious during the concurrent cognitive task. A moderate correlation was found between gait parameters (gait velocity and stride length) and CCTT-2 and PBS scores in children with TBI. Conclusion Gait performance may be affected by task complexity following TBI. Attention and balance deficits caused deterioration in gait performance under the concurrent task condition in children with TBI. This study illustrates the crucial role of task demand and complexity in dual-task interference.