Miracle-dz/UniFAR-FTUs huggingface dataset:
Cross-Talks between RKIP and YY1 through a Multilevel Bioinformatics Pan-Cancer Analysis

Simple Summary To better understand the potential implications of the cross-talk between RKIP and YY1 in cancer, we comprehensively analyzed different cancer types using bioinformatics approaches. Our study focused on analyzing the expression, mutation, immune infiltration, and drug resistance profiles of the two genes, using large-scale datasets from public repositories such as the Cancer Genome Atlas (TCGA) and the Cancer Proteome Atlas (TCPA). By integrating multiple data sources and applying advanced computational methods, we aimed to identify novel insights into the role of PEBP1/RKIP and YY1 in cancer, as well as potential therapeutic targets and biomarkers. Overall, our study provides new evidence that the cross-talk between RKIP and YY1 might be an important regulator of cancer progression and drug resistance, with potential clinical implications. By elucidating the complex interplay between these two genes, our findings may help in the development of more effective diagnostic and therapeutic strategies for cancer. Abstract Recent studies suggest that PEBP1 (also known as RKIP) and YY1, despite having distinct molecular functions, may interact and mutually influence each other’s activity. They exhibit reciprocal control over each other’s expression through regulatory loops, prompting the hypothesis that their interplay could be pivotal in cancer advancement and resistance to drugs. To delve into this interplay’s functional characteristics, we conducted a comprehensive analysis using bioinformatics tools across a range of cancers. Our results confirm the association between elevated YY1 mRNA levels and varying survival outcomes in diverse tumors. Furthermore, we observed differing degrees of inhibitory or activating effects of these two genes in apoptosis, cell cycle, DNA damage, and other cancer pathways, along with correlations between their mRNA expression and immune infiltration. Additionally, YY1/PEBP1 expression and methylation displayed connections with genomic alterations across different cancer types. Notably, we uncovered links between the two genes and different indicators of immunosuppression, such as immune checkpoint blockade response and T-cell dysfunction/exclusion levels, across different patient groups. Overall, our findings underscore the significant role of the interplay between YY1 and PEBP1 in cancer progression, influencing genomic changes, tumor immunity, or the tumor microenvironment. Additionally, these two gene products appear to impact the sensitivity of anticancer drugs, opening new avenues for cancer therapy.
Surface Deformation in the Chengdu Plain Area Produced by the Wenchuan Ms8.0 Earthquake of 12 May 2008, Sichuan, China

The 12 May 2008 Wenchuan MS8.0 (Mw7.9) earthquake occurred on the Longmen Shan (Mountains) thrust-nappe structure zone in the eastern margin of the Tibetan plateau. It has produced 240 km long and 72 km long rupture zones on the surface along the Yingxiu–Beichuan fault and Guanxian–Jiangyou fault, respectively, which are branches of the Longmen Shan fault system. Besides, our field investigation found that this shock has also caused a weak rupture zone on the ground nearby the Shigu town, Shifang city that lies in the western Chengdu plain east to the epicenter. This rupture zone and the other two ruptures in the Longmen Shan mountainous area aforementioned constitute a northwest-dipping imbricate structure. It is about 7.5 km long, trends in 30-, and is manifested by a series of deformation phenomena such as damages of buildings, channel dislocations, ground folds, erupted sand and earth fissures on the surface. Observations in the exploratory trenches indicate that there is a fold uplift of 0.2 m in the youngest strata (including the surface) produced by the Wenchuan MS8.0 event, and a fold uplift of 0.4 m in the clay bottom in the trench, presumably resulted from a paleoearthquake of similar size to the Wenchuan shock in 2008. Seismic exploration of shallow subsurface demonstrates that in the place of seismic rupture zone in the Chengdu plain exist active faults of the late Pleistocene as well as active folds of the Quaternary.
Pentacentra Transformer for Multiphase LLC Converter in High-Current Data Center Application

The role of data centers has become significant in the era of information technology, and their operation consumes a substantial amount of energy. Therefore, the point-of-load converter or voltage regulation module used in data centers must have high efficiency and power density to deliver a large current to specific servers. A common bus voltage 48 V at the rack stage needs to be stepped down to intermediate bus voltage, which is 6–5 V in this case. To achieve this, a new pentacentra transformer was developed for a four-phase LLC converter. A centra bar serving as the fifth leg of the core is added to the conventional four-leg matrix transformer. The interleaving and integration of windings in the proposed pentacentra transformer enabled balanced current sharing and reduced conduction loss by 45% compared to the traditional winding layout. The experimental prototype of the converter was designed to achieve 800 W power output at a switching frequency of 500 kHz and 48 V–40 V/6 V–5 V voltage conversion. The peak efficiency achieves 98.1% along with the power density of 240 W/in3 with the experimental result. Without the heatsink, the whole converter is operating at rated power within a safe temperature lower than 86°. The excellent thermal performance ensures the reliable operation of the converter and promises a larger power delivery capability.
Factors controlling CO2 exchange in a middle latitude forest

[1] The forest carbon uptake experiences a relatively steady state, in which both radiation use efficiency and Bowen ratio exhibit relatively small change in tendency during the middle growing season at a deciduous forest in New England. The net ecosystem exchange (NEE) during the steady state varies from 2.1 to 5.1 Mg C Ha−1 y−1, accounting for 58–83% of the annual amount over 1992–2004. The cloudiness, combined with the effect of antecedent accumulated precipitation from late January, plays a key role in controlling interannual fluctuations of the steady state GEE and NEE among other environmental factors, and determines the long-term trend of the site GEE and NEE. These two factors account for 74% of the interannual variability of forest carbon uptake for the steady state, and 58% for the entire growing season, respectively. This suggests that winter precipitation and summer clouds probably play a key role in regulating the carbon uptake, an important mechanism of the carbon cycle/climate interaction.
Stratospheric NO2 trends over the high mountain ‘Ottavio Vittori’ station, Italy

This paper presents an evaluation of the nitrogen dioxide (NO2) trend inferred from UV–visible zenith-sky measurements performed at the ‘Ottavio Vittori’ ground-based research station (http://www.isac.cnr.it/cimone) at Monte Cimone (44.18° N, 10.7° E, 2165 m above sea level (a.s.l.)). Experimental data series are obtained from the measured spectra adopting a retrieval procedure according to differential optical absorption spectroscopy (DOAS) methodology. Data series cover the period from 1993 to 2009, with limited interruptions due to technical maintenance of the instrument or poor meteorological conditions. The NO2 trends are calculated with a linear regression model considering different factors assumed to contribute to NO2 atmospheric content. Before running the model, a procedure for data quality control was applied to reduce or exclude the influence of measurements affected by poor meteorological conditions or the vertical transport of polluted air masses from the lower troposphere. The negative trends obtained for sunrise (a.m.) and sunset (p.m.) NO2 measurements are in good agreement with previous studies accomplished for ground-based stations in the northern hemisphere.
Prediction underlying comprehension of human motion: an analysis of Deaf signer and non-signer EEG in response to visual stimuli

Introduction Sensory inference and top-down predictive processing, reflected in human neural activity, play a critical role in higher-order cognitive processes, such as language comprehension. However, the neurobiological bases of predictive processing in higher-order cognitive processes are not well-understood. Methods This study used electroencephalography (EEG) to track participants' cortical dynamics in response to Austrian Sign Language and reversed sign language videos, measuring neural coherence to optical flow in the visual signal. We then used machine learning to assess entropy-based relevance of specific frequencies and regions of interest to brain state classification accuracy. Results EEG features highly relevant for classification were distributed across language processing-related regions in Deaf signers (frontal cortex and left hemisphere), while in non-signers such features were concentrated in visual and spatial processing regions. Discussion The results highlight functional significance of predictive processing time windows for sign language comprehension and biological motion processing, and the role of long-term experience (learning) in minimizing prediction error.
THE Malaŵi Earthquake of March 10, 1989: DEep faulting within the East African Rift System

Since 1964 there have been six earthquakes of Mw ≥ 5.5 in east Africa whose centroid depths have been demonstrated to be in the range of 25–40 km. These depths are significantly greater than the 5- to 15-km range typical of most other regions of continental extension. The March 10, 1989 earthquake (Mw 6.1) in Malaŵi is the first such deep event to have occurred within the main topographic expression of the late Cenozoic east African rift system. Its focal mechanism and depth (32 ± 5 km) allow it to be plausibly associated with slip on a deep part of a major normal fault zone bounding the Malaŵi rift. We cannot determine whether the earthquake occurred in the crust or mantle or whether the postulated fault zone exists as a continuous seismogenic surface from the upper crust to depths of ∼30 km: it is possible that the fault zone exists as an aseismic shear zone in the lower crust. In the Malaŵi rift the width of the half graben (up to 50 km), the effective elastic thickness of the lithosphere (∼35 km), and probably the largest fault segment lengths (>50 km) are greater than is typical in rifts outside Africa. We suggest that these features and the greater earthquake depths are all related to the likelihood that the upper part of the lithosphere is colder and stronger than is typical elsewhere. These observations are consistent with earlier suggestions that normal faulting and significant strength can exist throughout the bulk of the crustal thickness. If this is the case, wide half graben can form without requiring shear strengths on the bounding faults to be greater than 1–10 MPa (10–100 bars), which is the typical level of stress drop observed in earthquakes.
Implications of the enhanced Brewer-Dobson circulation in European Centre for Medium-Range Weather Forecasts reanalysis ERA-40 for the stratosphere-troposphere exchange of ozone in global chemistry transport models

[1] The European Centre for Medium-Range Weather Forecasts 45-year reanalysis (ERA-40) exhibits an enhanced Brewer-Dobson circulation, as is demonstrated for the year 1997 by examining the air mass transport across the 100-hPa level and the tropopause. On the basis of a linearized ozone (Linoz) scheme for stratospheric chemistry it is estimated that the corresponding net downward transport of ozone to the lowermost stratosphere and the troposphere would be a factor 2–3 too high. Different methods are evaluated to simulate the downward transport of stratospheric ozone in tropospheric chemistry transport models driven by ERA-40 meteorology. The synthetic ozone (Synoz) model, which is sometimes used to constrain the influx of stratospheric ozone by imposing its chemical production rate in the middle stratosphere, in the case of ERA-40 leads to an unacceptable depletion of the upper troposphere/lower stratosphere region, with nearly halved ozone concentrations at 100 hPa. A better alternative is to constrain the zonal mean concentrations in the lower stratosphere by relaxation to an ozone climatology. If ozone is relaxed down to 100 hPa in the extratropics, the net downward transport of ozone is reduced by more than a factor of 2. Finally, we investigate to what extent the circulation bias persists in the forecasts of the reanalysis. The use of forecasts beyond the 6-hour “first guess” in combination with relaxation yields a further reduction of the stratosphere-troposphere exchange of ozone, the 100-hPa flux approaching the range of observational estimates. An additional advantage of using forecasts is that the exchange of chemical constituents other than ozone is improved concurrently.
Palaeozoic glacial depositional environments of SW Saudi Arabia: process and product

Abstract Saudi Arabia is one of the few places in Gondwana where deposits of two Palaeozoic glaciations are well preserved. They were formed under similar conditions in a tectonically stable shelf setting. We studied the sedimentary facies and architectural geometries of Upper Ordovician and Permo-Carboniferous glaciogenic deposits in the Wajid Sandstone and developed a genetic model for both units. Common features and of both glacial episodes are (a) incision of glacial (tunnel? ) valleys, (b) subsequent valley fill by proglacial deposits in front of an oscillating, polythermal ice shield; (c) intra-formational erosional events through repeated ice advance, (d) widespread and large-scale soft deformation due to glacial surge during deglaciation, and (e) marine transgression most probably due to eustatic sea-level rise following deglaciation. The general patterns and observations fit well with recently published observations on Upper Ordovician deposits in northern Africa, pointing to closely coupled glaciological processes of the North African–Arabian ice shield. Although the same general patterns apply for the Permo-Carboniferous glaciation, sedimentary styles and petrographical properties differ, probably due to a more heterogeneous ice-flow pattern controlled by a more pronounced topography after the Hercynian tectonic event.
In Silico Exploration and Experimental Validation of Camellia sinensis Extract against Rhipicephalus microplus and Sarcoptes scabiei: An Integrated Approach

Sarcoptes scabiei is an ectoparasite of humans and animals that causes scabies. The Rhipicephalus (Boophilus) microplus is a blood-sucking ectoparasite that transmits various pathogens. These two parasites have caused great losses to a country’s dairy and agriculture sectors. The aim of this study was to determine the in vitro and in silico efficacy of Camellia sinensis plant extracts. Different concentrations of C. sinensis ethanolic plant extracts were prepared using the maceration method and were used against mites and ticks (in adult immersion test AIT and larval packet test LPT) to evaluate their in vitro acaricidal activity. Additionally, in silico molecular docking was performed to investigate the inhibitory interactions between the phytochemicals of the plant and S. scabiei and R. microplus glutathione transferase proteins (SsGST and RmGST). This study observed that the plant extract showed high efficacy in vitro against mites and different tick stages in adult immersion and larval packet tests. Additionally, the in silico study revealed a strong binding interaction between ellagic acid and SsGST protein, with a binding energy of −7.3 kcal/mol, with respect to permethrin (−6.7 kcal/mol), whereas quercetin and RmGST resulted in a docking score of −8.6 kcal/mol compared to deltamethrin (−8.2 kcal/mol). Overall, this study explored the potential of C. sinensis as a natural alternative for controlling tick and mite infestations and provided insights into the inhibitory mechanisms of its phytochemicals.
A sedimentary record of Holocene surface runoff events and earthquake activity from Lake Iseo (Southern Alps, Italy)

This study presents a record of Holocene surface runoff events and several large earthquakes, preserved in the sediments of pre-Alpine Lake Iseo, northern Italy. A combination of high-resolution seismic surveying, detailed sediment microfacies analysis, non-destructive core-scanning techniques and AMS 14C dating of terrestrial macrofossils was used to detect and date these events. Based on this approach, our data shed light on past seismic activity in the vicinity of Lake Iseo and the influence of climate variability and human impact on allochthonous detrital matter flux into the lake. The 19 m long investigated sediment sequence of faintly layered lake marl contains frequent centimetre- to decimetre-scale sandy-silty detrital layers. During the early to mid Holocene, these small-scale detrital layers, reflecting sediment supply by extreme surface runoff events, reveal a distinct centennial-scale recurrence pattern. This is in accordance with regional lake-level highstands and minima in solar activity and thus apparently mainly climate-controlled. After c. 4200 cal. yr BP, intervals of high detrital flux occasionally also correlate with periods of enhanced human settlement activity. In consequence, deposition of small-scale detrital layers during the late Holocene apparently reflects a rather complex interplay between climatic and anthropogenic influences on catchment erosion processes. Besides the small-scale detrital layers, five up to 2.40 m thick large-scale detrital event layers, composed of basal mass-wasting deposits overlain by large-scale turbidites, were identified, which are supposed to be triggered by strong earthquakes. The uppermost large-scale event layer can be correlated to a documented Mw=6.0 earthquake in ad 1222 in Brescia. The four other large-scale event layers are supposed to correspond to previously undocumented local earthquakes. These occurred around 350 bc, 570 bc, 2540 bc and 6210 bc and most probably also reached magnitudes in the order of Mw = 5.0–6.5.
Characteristics of the Inflammatory Bowel Disease in Children: A Croatian Single-Centre Retrospective Study

Inflammatory bowel diseases (IBDs), encompassing ulcerative colitis (UC) and Crohn’s disease (CD), are chronic gastrointestinal disorders often diagnosed in youth, presenting unique features compared to adult-onset cases. We aimed to profile pediatric IBD patients in Croatia through a retrospective analysis of children up to 18 years old diagnosed with IBD at the University Hospital of Split from 1 January 2012, to 31 December 2021, utilizing data collected during hospitalization for diagnosis. Over a decade, 107 children were diagnosed, with 43.9% having UC, 55.1% CD, and 0.9% IBD-unclassified. Median age at diagnosis was 14.1 years, with UC patients being older (14.8 vs. 13.7 years, p = 0.044). Males constituted 60.7% of patients. Median symptom duration was 2.0 months, with CD patients experiencing a longer diagnostic delay (3.0 vs. 2.0 months, p = 0.003). The median incidence rate was 9.89 (95% CI 5.93–13.84) per 100,000 children/year, varying across age groups. Median (IQR) BMI z-score was −0.34 (−0.97–0.45). Common symptoms included diarrhea (60.7%) and abdominal pain (50.5%), with rectal bleeding more prevalent in UC (72.3% vs. 32.2%, p < 0.001). While our study offers valuable insights into pediatric IBD in Croatia, further prospective research is needed to clarify disease progression and development.
Strategic Spatial Planning

Abstract The last century left us with various definitions and interpretations of strategic spatial planning. What seems clear today is that strategic planning could be considered a set of concepts, procedures and tools (Albrechts 2004), usefully adaptable to fit the current planning needs of modern states and local societies in Europe. At the beginning of the 1990s, many experiences from all over the continent caught the interest of theorists and practitioners and started a long debate on the revival of strategic spatial planning (Salet and Faludi, eds., 2000). If we look at the practices though, it is evident that the approaches and goals are diverse and inevitably strongly related to specific local contexts. During the last decade, a particularly significant one for Italy due to the many social and institutional changes, several metropolitan areas and city-regions have been experimenting with strategic plans. These plans are aimed at encouraging local actors to get together and develop shared visions for the future. Even if a few common features are recognizable in all these plans, each of these tools is context-specific and develops particular procedures aimed at specific goals. An evaluation of this fruitful endeavour is not yet unequivocally possible, but the creative potential of these informal tools is already evident in the discovery of new actors and forms of local action, the development of local governance at variable geometries and in fostering local endogenous seeds of development.
The geological structure of the Wadi el Dirba area of Sinai

Summary The Egyptian province of Sinai can be divided into three geological regions: (1) the northern plain, the isthmus, whose surface outcrops are confined chiefly to strata of Mesozoic age, (2) the mountainous peninsula, formed of a complex of Pre-Cambrian rocks, and (3) the western coastal belt, flanking the Gulf of Suez and largely made up of a series of rocks belonging to the Mesozoic and Tertiary. The rocks of the coastal belt have been involved in the rift-faulting movement which produced the Gulf of Suez trough. The effect of these movements was to break up the whole area into a series of tilted blocks. The rocks of the isthmus dip gently towards the Mediterranean, but this regional dip is broken by a number of fold-axes and associated faults which trend WSW. -EXE. They form the western extension of a similar group in Palestine. The particular interest in the Wadi el Dirba area lies in the fact that it is there possible to establish the relationship between the isthmus structures and the Rift movements. The field evidence within the area mapped may be summarized as follows:– 1. There are four normal faults belonging to the Rift system. One of them has a dyke associated with it (both dyke and faults can be established in age as Oligocene from evidence outside the area); one fault also appears to show some horizontal movement. 2. Another normal fault, the Dirba fault, running through the area in a direction parallel to the isthmus structures and assumed to be associated with them is displaced by the Rift faults. Movement along the Dirba fault must therefore have ceased before the main Rift faulting began. Reference is also made to other evidence beyond the area mapped which indicates (1) that the main Rift faulting movement was active during and after Miocene as well as during Oligocene times, and (2) that the isthmus folds may owe their origin predominantly to vertical rather than to horizontal movement.
Recent Developments on the First Chen Inequality in Differential Geometry

One of the most fundamental interests in submanifold theory is to establish simple relationships between the main extrinsic invariants and the main intrinsic invariants of submanifolds and find their applications. In this respect, the first author established, in 1993, a basic inequality involving the first δ-invariant, δ(2), and the squared mean curvature of submanifolds in real space forms, known today as the first Chen inequality or Chen’s first inequality. Since then, there have been many papers dealing with this inequality. The purpose of this article is, thus, to present a comprehensive survey on recent developments on this inequality performed by many geometers during the last three decades.