Miracle-dz/UniFAR-FTUs huggingface dataset:
CHRONIC MAXILLARY SINUSITIS, AN UNCOMMON AETIOLOGICAL FACTOR OF HEADACHE

Objective: To emphasize that headache due to chronic sinusitis must be differentiated from all other forms of headache clearing the misconception of relating almost every headache with sinusitis. Design: This is a descriptive study. Place and Duration of Study: The study was carried out at the ENT, SHIFA hospital Karachi from March 2002 to March 2004. Patients and Methods: This study was carried out on 100 patients who were selected from the OPD as convenient sampling. It included patients referred to otolaryngology department who were having radiological evidence of maxillary sinusitis on plain x-ray PNS and were being investigated for headache of more than one-month duration. All the patients underwent a detailed history, clinical and E.N. T. examinations. Bilateral antral washouts were performed. Patients were compared on the bases of various parameters for instance age, gender, duration, severity, type and location of headache, effects of treatment for chronic sinusitis in ameliorating headache. A follow up for a period of three months were carried out. After the study the collected data was processed, analyzed and the final results were made. Results: Majority of the cases belonged to the age group of 21 to 35 years (70%). A large majority of the patients were not sure about any aggravating conditions. 28% cases were unable to recognize any pain-relieving factor. Only 9% patients were severely affected. 23% patients were having structured problems e.g., deviated nasal septum, nasal polypi and enlarged turbinates. In 39% cases antral wash on one or both sides revealed mucoid discharge. 17% patients expressed that they were markedly improved with the treatment. 83% did not improve remarkably, revealing that chronic maxillary sinusitis was not the main cause of headache in those patients. Conclusion: It was concluded that although sinusitis is associated with headache in majority of the cases but headache is not a major symptom in chronic maxillary sinusitis. Patients primarily presenting with headache have chronic sinusitis in a few cases only. It is recommended that not all the patients of headache with hazy X-ray PNS should be subjected to only the treatment of chronic sinusitis to relieve headache.
Stop to Unlock-Improving the Security of Unlock Patterns on Mobile Devices

In this master thesis, we propose a security improvement for traditional unlock patterns as found in modern off-the-shelf smartphones. With our StopUnlock Patterns we propose to add a stop component which lets users define nodes where they deliberately stop for a limited amount of time before swiping to the next node of their unlock pattern. We argue that this stop component lets users select higher entropy patterns with only a minimal impact on usability metrics (such as authentication time and error rate) in comparison to simply increasing the length of the pattern. To evaluate StopUnlock Patterns, we conducted a lab study (n=40), a field study (n=14) and a security evaluation. Our findings suggest that StopUnlock Patterns (i) are easy to use, (ii) are memorable, and (iii) improve security.
PERBEDAAN PENYESUAIAN DIRI PENSIUNAN YANG MENDAPATKAN TRAINING PRA PENSIUN DENGAN YANG TIDAK MENDAPATKAN TRAINING PRA PENSIUN

ABSTRAK Masa pensiun merupakan masa dimana individu kehilangan aktivitas bekerja di kantor dan mulai mencari kegiatan baru untuk mengganti aktivitas formal tersebut. Dibutuhkan penyesuaian diri untuk melalui masa-masa tersebut, salah satunya dengan mengikuti training pra pensiun. Training pra pensiun merupakan sebuah pelatihan yang diberikan kepada karyawan yang akan memasuki masa pensiun. Melalui training pra pensiun, pensiunan dapat merubah sikap menuju lebih positif terhadap masa pensiun dengan cara mengikuti seminar persiapan masa pensiun. Penyesuaian diri pensiunan yang baik adalah menerima keterbatasan-keterbatasan yang tidak bisa berubah dan secara aktif memodifikasi keterbatasan yang masih bisa diubah. Berdasarkan latar belakang tersebut penelitian ini bertujuan untuk mengetahui perbedaan penyesuaian diri pensiunan pada pensiunan yang mendapatkan training pra pensiun dengan yang tidak mendapatkan training pra pensiun.Hipotesis penelitian yaitu terdapat perbedaan penyesuaian diri pensiunan yang mendapatkan training pra pensiun dengan yang tidak mendapatkan training pra pensiun. Sampel penelitian adalah pensiunan yang mendapatkan training pra pensiun, yaitu PT PLN Persero yang berjumlah 24 orang, dan 24 orang PT POS Indonesia dan PT Kimia Farma yang tidak mendapatkan training pra pensiun. Pengumpulan data dilakukan dengan menggunakan skala Penyesuaian Diri Pensiunan yang disusun berdasarkan teori Habber dan Runyon (1984). Hasil analisis data menggunakan teknik komparasi Independent Sample T-Test menunjukkan signifikansi P=0,000 (p
Design Intentions: Engineering Students Looking Ahead to their Future Design Behavior

In this paper, we present findings of what students declare as their intention to engage in a design behavior after they have participated in a classroom exercise. Specifically, we analyzed data from 73 students from two different classes in a college of engineering in a large public research-intensive university who participated in a classroom activity that took approximately 50 minutes long. After learning about design processes of engineers with various levels of expertise and responding to questions about what they found to be important information, students were asked ‘Will Information from this exercise affect how you will do design in the future? How? ’ Through coding students’ responses, we discovered that students are thinking metacognitively about design through articulating plans, efficient use of time, monitoring their steps, and evaluating their design processes. While all students can articulate their design intentions, some students explore a nuanced understanding of their design intentions and subsequent actionable strategies that could impact how they design in the future. This practical classroom activity can be used at the beginning of time-intensive design experiences (such as term-long design projects or capstone design courses) to help students develop a targeted understanding of important aspects of the design processes and set intentions for how they will engage in their design projects.
COPD_A_250080 1565..1575

Seigo Miyoshi 1 Hitoshi Katayama Minoru Matsubara Takahide Kato Naohiko Hamaguchi 1 Osamu Yamaguchi 1Department of Cardiology, Pulmonology, Hypertension and Nephrology, Ehime University Graduate School of Medicine, Toon, Ehime 7910295, Japan; 2Department of Internal Medicine, Sumitomo Besshi Hospital, Niihama, Ehime 792-8543, Japan Background and Objective: Spirometry is sometimes difficult to perform in elderly patients and patients with cognitive impairment. Forced oscillometry (FOT) is a simple, noninvasive technique used for measuring respiratory impedance. The aim of this study was to develop regression equations to estimate vital capacity (VC), forced vital capacity (FVC), and forced expiratory volume in 1 s (FEV1.0) on the basis of FOT indices and to evaluate the accuracy of these equations in patients with asthma, chronic obstructive pulmonary disease (COPD), and interstitial lung disease (ILD). Materials and Methods: We retrospectively included data on 683 consecutive patients with asthma (388), COPD (128), or ILD (167) in this study. We generated regression equations for VC, FVC, and FEV1.0 by multivariate linear regression analysis and used them to estimate the corresponding values. We determined whether the estimated data reflected spirometric indices. Results: Actual and estimated VC, FVC, and FEV1.0 values showed significant correlations (all r > 0.8 and P < 0.001) in all groups. Biases between the actual data and estimated data for VC, FVC, and FEV1.0 in the asthma group were −0.073 L, −0.069 L, and 0.017 L, respectively. The corresponding values were −0.064 L, 0.027 L, and 0.069 L, respectively, in the COPD group and −0.040 L, −0.071 L, and −0.002 L, respectively, in the ILD group. The estimated data in the present study did not completely correspond to the actual data. In addition, sensitivity for an FEV1.0/FVC ratio of <0.7 and the diagnostic accuracy for the classification of COPD grade using estimated data were low. Conclusion: These results suggest that our method is not highly accurate. Further studies are needed to generate more accurate regression equations for estimating spirometric indices based on FOT measurements.
Effect of Ezetimibe on (Hepatic/Adipose Tissue) Glucose Metabolism and Inflammatory Markers

Ezetimibe is a drug that inhibits Niemann-Pick C1-Like 1 which reduces cholesterol absorption. Despite numerous investigations, the effects of ezetimibe on glucose metabolism have not yet been clearly identified. In this study, we aimed to investigate the effects of ezetimibe on glucose metabolism and inflammatory markers in a cell model, a rodent model, and in human. By identifying the molecular mechanisms of action, we aimed to determine whether ezetimibe can be safely used in patients with diabetes and hepatic steatosis. Methods In the ezetimibe groups, C57BL/6J mice and Wistar rat models both showed partial improvement in several glucose metabolism indices. Smaller fat cell size and reduced M1-polarized macrophage accumulation were also observed in the ezetimibe groups. Anti-inflammatory M2 phenotype of macrophages and fatty acid oxidation were induced within adipocytes. Free fatty acid levels were decreased in serum. However, these changes did not lead to systemic lowering of blood sugar levels, and improvement of hepatic steatosis was not significant in this group. Clinical data analysis showed that statin monotherapy significantly increased insulin resistance. However, the use of ezetimibe in combination with statin did not increase insulin resistance, measured using the Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) index. Conclusion Ezetimibe reduced the size of visceral fat adipocytes and serum level of free fatty acid, and induced fatty acid oxidation. It improved the inflammation of adipocytes, and partially improved glycemic indices. No. 4691S), p-Akt (Ser473, Cell signaling, Cat. No. 4060S). Anti-mouse IgG, horseradish peroxidase (HRP)-linked Antibody (Santacruz, Cat. No. sc-516102) and anti-rabbit IgG, HRP-linked Antibody (Cell signaling, 7074S) were used as secondary antibodies. NPC1L1 expression in liver tissue was also confirmed.
Imaging in stone diagnosis and surgical planning

Purpose of Review Radiological imaging techniques and applications are constantly advancing. This review will examine modern imaging techniques in the diagnosis of urolithiasis and applications for surgical planning. Recent Findings The diagnosis of urolithiasis may be done via plain film X-ray, ultrasound (US), or contrast tomography (CT) scan. US should be applied in the workup of flank pain in emergency rooms and may reduce unnecessary radiation exposure. Low dose and ultra-low-dose CT remain the diagnostic standard for most populations but remain underutilized. Single and dual-energy CT provide three-dimensional imaging that can predict stone-specific parameters that help clinicians predict stone passage likelihood, identify ideal management techniques, and possibly reduce complications. Machine learning has been increasingly applied to 3-D imaging to support clinicians in these prognostications and treatment selection. Summary The diagnosis and management of urolithiasis are increasingly personalized. Patient and stone characteristics will support clinicians in treatment decision, surgical planning, and counseling.
T HE I NHIBITING F ACTORS THAT P RINCIPAL I NVESTIGATORS E XPERIENCE IN L EADING P UBLICLY F UNDED R ESEARCH P ROJECTS

Securing public funding to conduct research and leading it by being a principal investigator (PI) is seen as significant career development step. Such a role brings professional prestige but also new responsibilities beyond research leadership to research management. If public funding brings financial and infrastructure support, little is understood about the inhibiting factors that publicly funded PIs face given the research autonomy offered by publicly funded research. Our study finds that there are three key PI inhibiting factors 1) political and environmental, 2) institutional and 3) project based. Traditional knowledge, skills and technical know-how of publicly funded PIs are insufficient to deal with the increasing managerial demands and expectations i.e. growing external bureaucracy of public funding agencies. Public funding is no longer the ‗freest form of support‘ as suggested by Hackett (1990) and the inhibiting factors experienced by publicly funded PIs limits their research autonomy. We also argue that PIs have little influence in overcoming these inhibiting factors despite their central role in conducting publicly funded research.
Inactivation of aPKClambda reveals a context dependent allocation of cell lineages in preimplantation mouse embryos.

Background: During mammalian preimplantation development, lineage divergence seems to be controlled by the interplay between asymmetric cell division (once cells are polarized) and positional information. In the mouse embryo, two distinct cell populations are first observed at the 16-cell stage and can be distinguished by both their position (outside or inside) and their phenotype (polarized or non-polarized). Many efforts have been made during the last decade to characterize the molecular mechanisms driving lineage divergence. Methodology/PrincipalFindings: In order to evaluate the importance of cell polarity in the determination of cell fate we have disturbed the activity of the apical complex aPKC/PAR6 using siRNA to down-regulate aPKC l expression. Here we show that depletion of aPKC l results in an absence of tight junctions and in severe polarity defects at the 16-cell stage. Importantly, we found that, in absence of aPKC l , cell fate depends on the cellular context: depletion of aPKC l in all cells results in a strong reduction of inner cells at the 16-cell stage, while inhibition of aPKC l in only half of the embryo biases the progeny of aPKC l defective blastomeres towards the inner cell mass. Finally, our study points to a role of cell shape in controlling cell position and thus lineage allocation. Conclusion: Our data show that aPKC l is dispensable for the establishment of polarity at the 8-cell stage but is essential for the stabilization of cell polarity at the 16-cell stage and for cell positioning. Moreover, this study reveals that in addition to positional information and asymmetric cell divisions, cell shape plays an important role for the control of lineage divergence during mouse preimplantation development. Cell shape is able to influence both the type of division (symmetric or asymmetric) and the position of the blastomeres within the embryo. In addition these experiments suggest also that a compensatory mechanism is at work at the 32-cell stage in aPKC l -depleted blastomeres: the percentage of inside cells in 32/2-cell stage aPKC l depleted embryos was 14% instead of 5% in aPKC l -depleted 16-cell embryos. This value is similar to the one observed in 16-cell stage wild-type embryos (16%). This is likely due to the ability of aPKC l depleted 32-cell stage blastomeres to establish tight junctions and to stabilize cortical polarity, thus behaving like wild-type cells.
Comparative analysis of the level of aggression between the women practicing judo and Brazilian jiu-jitsu

Aim : Comparison of the level of aggression between the women practicing judo and Brazilian jiu-jitsu against the average aggression level among Polish women. Materials and methods : A group of 30 women practicing judo and a group of 27 women practicing jiu-jitsu were tested by using a questionnaire to show the aggression level-‘Aggression questionnaire’ by Buss, Amity Institute with Polish adaptations. Results: The total decreasing in the aggression level was observed among the group of women practicing judo and partial among women practicing Brazilian jiu-jitsu. Conclusion : A longstanding practice of Brazilian jiu-jitsu by women results in decreasing of aggression level, what can be later used during planning therapeutic schemes.
Risk Factors Assessment for Cervical Lymph Node Metastasis in Head and Neck Squamous Cell Carcinoma: A Cross-Sectional Study

Background: Head and neck cancer in one of the most disturbing health problems considering morbidity and mortality. Detecting and treating occult lymph node metastasis have the most influence on patients’ survival in head and neck squamous cell carcinoma (SCC). This article aimed to introduce some potential risk factors for cervical node metastasis in this type of malignancy. Subjects & Methods: 164 patients with head and neck SCC who underwent cervical node dissection of all types from 2001 to 2011were enrolled in this study. Then the effect of the assumed risk factors including age, sex, smoking, alcohol, and opium, primary site of tumor and extra-capsular extension of involved lymph node son cervical lymph node involvement frequency were evaluated. Results: This study showed that cervical node metastasis was more frequent in older patients (mean age of 58.83 y/o) (P=0.038). On the other hand there was no significant difference in cervical lymph node metastasis in presence or absence of other assumed risk factors (P >0.05) in this series. There was no significant relationship between extra-capsular extension of involved lymph nodes with primary tumor site and levels of cervical node involvement too. Conclusion: This study revealed that maybe older patients (mean age of 58.83 y/o) with head and neck SCC are at higher risk for involvement of cervical nodes and they may receive more aggressive approach for detecting and treating occult cervical node metastasis.
A retrospective study on incidence of dystocia in buffaloes at a referral center

Total 232 buffaloes suffering with dystocia were analyzed to find out the incidence of different causes of dystocia in one year. The uterine torsion has been observed as a main cause of dystocia in maternal type however, deviation of head was prominent cause under fetal type causes of dystocia in buffalo. In summary, the incidence of dystocia can be minimized by adopting good managemental practices in the farm and houses as well.
ICSI outcome in PCOS women whom GnRH agonist was used as a Final Oocyte Maturation Trigger

Background: The introduction of gonadotropin releasing hormone (GnRH) agonist trigger for final maturation of oocytes in GnRH antagonist stimulated intra-cytoplasmic sperm injection (ICSI) cycles is widely used nowadays as it plays a major role in reducing ovarian hyper stimulation (OHSS) development in high responder patients e.g. polycystic ovary syndrome (PCOS). Polycystic ovary is one of the major causes of ovulatory dysfunction with an ICSI considered a suitable treatment modality in those patients with a high risk of multiple pregnancies and OHSS. Aim: The aim of this study is to compare ICSI outcome between GnRH agonist and hCG trigger in PCOS women stimulated by GnRH antagonist protocol. Materials and Methods: Forty one PCOS females were included. All were stimulated with GnRH antagonist protocol. When the total number and size of the developing follicles were accepted, oocyte maturation was triggered and they were divided in to two groups according to the type of the trigger: hCG trigger (n=18) and GnRH agonist (n=23). Following oocytes retrieval, microscopic assessment of oocytes maturity and embryos quality was done followed by calculation of pregnancy rate with a comparison of the results between both groups. Results: females whom their oocytes' maturation was triggered by GnRH agonist exhibited no significant difference regarding the total number of retrieved oocytes, oocytes' maturation rate and total number of good quality embryos in comparison with hCG-triggered at a p-value more than 0.05. While pregnancy rate in GnRH agonist was significantly less 22.72% vs 28.57% in hCG-triggered females, p-value=0.01. Conclusion: Triggering with GnRH agonist had a comparable ICSI outcome to hCG inform of oocytes and embryos quality. The exception is pregnancy rate which is significantly lower with GnRH agonist which indicates that GnRH agonist might have unfavorable effect on endometrial receptivity lowering implantation rate.
Lutein Interacts with Ascorbic Acid More Frequently than with (cid:1) -Tocopherol to Alter Biomarkers of Oxidative Stress in Female Zucker Obese Rats 1,2

The inﬂuence of dietary lutein, with and without moderate amounts of vitamin C (VC) or vitamin E (VE), on biomarkers of oxidative stress was examined in rats. Nine groups of immature Zucker obese ( fa/fa ) and lean female rats (8/group) consumed ad libitum for 8 wk the AIN-93G diet (Control) to which was added either dl - (cid:1) -tocopherol acetate (VE) at 0.60 mg/kg or ascorbic acid (VC) at 0.75 mg/kg diet. Each of these diets contained lutein oil (FloraGlo) at 0.5 (Lut0.5) or 1.0 (Lut1.0) mg/kg diet. Weight gain, food efﬁciency and relative liver weight were higher in obese than in lean rats. Although liver malondialdehyde (MDA) concentrations were signiﬁcantly higher in obese than in lean rats, levels were signiﬁcantly lower in obese rats fed VE, VE-Lut and VC-Lut0.5 compared with other obese groups. The accumulation of (cid:1) -tocopherol in liver was 6- and 3-times greater in the VE and VE-Lut1.0 groups, respectively, compared with the obese and lean control groups. Lutein reduced the activity of superoxide dismutase (SOD) in obese rats, independent of VC or VE, and raised the activity of glutathione peroxidase to higher levels in lean rats when combined with VC. Plasma insulin levels were dramatically higher in obese compared with lean rats, but signiﬁcantly lower in obese rats fed VC-Lut0.5, VE-Lut1.0 and Lut1.0 compared with the Control group. These results suggest that lutein independently reduces the activity of SOD and alters more biomarkers of oxidative stress when combined with vitamin C than with vitamin E, and that vitamin E reduces liver lipid peroxidation in obese rats when the accumulation of liver (cid:1) -tocopherol is very high. J. Nutr. 133: 2838–2844, 2003. IN) used in the study were housed individually in suspended wire mesh–bottomed cages. Lighting in the animal room was on a 12-h light:dark cycle with lights on 0700–1900 h. The temperature was maintained at 18–26°C and relative humidity at 40–70%. After a 1-wk acclimation period, obese and lean rats were assigned to one of the nine experimental groups. Animal care con-formed to the principles and guidelines set forth by the National Academy of Sciences (22).
Longitudinal Investigation into the Role of Reading Self- Concept on Reading Achievement for English as a First Language and English Language Learners

Reading self-concept—students’ perceived competence and enjoyment in reading—is theorized to influence reading development. Multi-group confirmatory factor analysis and two, cross-panel structural equation models were used to investigate the measurement invariance and structural relationship between reading self-concept and reading achievement from grade 3 to grade 6 in a cohort comprised of students with English as a first language (EL1; n= 8947) and English language learners (ELL; n= 8942). Reading self-concept and reading achievement were invariant in factor loadings, but not item intercepts, between EL1 and ELL students. Reading self-concept influences subsequent reading achievement for EL1 students, while reading achievement influences later self-concept for ELL students. Thus, to maximize the effectiveness of grade 3 reading instruction, foundational reading skills should be the primary focus of instruction for ELL students. These results highlight the unique relationship between reading self-concept and achievement among ELLs.