Miracle-dz/UniFAR-FTUs huggingface dataset:
Trastuzumab decreases the incidence of clinical relapses in patients with early breast cancer presenting chemotherapy-resistant CK-19mRNA-positive circulating tumor cells: results of a randomized phase II study

Background: Since the detection of circulating tumor cells (CTCs) which express HER2 is an adverse prognostic factor in early breast cancer patients, we investigated the effect of trastuzumab on patients ’ clinical outcome. Patients and methods: Seventy ﬁ ve women with HER2 (-) breast cancer and detectable CK19 mRNA-positive CTCs before and after adjuvant chemotherapy, were randomized to receive either trastuzumab ( n = 36) or observation ( n = 39). CK19 mRNA-positive CTCs were detected by RT-PCR and double stained CK(+)/HER2(+) cells by immuno ﬂ uorescence. The primary endpoint was the 3-year disease-free survival rate. Results: Fifty-one (89%) of the 57 analyzed patients had HER2-expressing CTCs. After trastuzumab administration, 27 of 36 (75%) women became CK19 mRNA-negative compared to seven of 39 (17.9%) in the observation arm ( p = 0.001). After a median follow up time of 67.2 months, four (11%) and 15 (38%) relapses were observed in the trastuzumab and observation arm, respectively ( p = 0.008); subgroup analysis indicated that this effect was mainly con ﬁ ned to women with >3 involved axillary lymph nodes (p = 0.004). The median DFS was also signi ﬁ cantly higher for the trastuzumab-treated patients ( p = 0.008). Conclusion: Administration of trastuzumab can eliminate chemotherapy-resistant CK19 mRNA-positive CTCs, reduce the risk of disease recurrence and prolong the DFS. Background: Identi ﬁ cation of predicting factors for anthracyclines-based chemotherapy remains a clinical challenge. Glutathione S -transferase (GSTs) enzymes detoxify chemotherapy drugs and their metabolites. Several polymorphisms in GST genes result in reduced or no activity of the enzymes. Speci ﬁ cally, GSTM1 and GSTT1 genes are polymorphically deleted, the polymorphism GSTP1 c.313A > G (rs1695) determines the amino acid substitution Ile 105 Val, where the Val-containing enzyme has reduced activity. Also, GSTA1 *B allele has reduced levels of GSTA1 enzyme. Several polymorphisms in GSTs have been associated with differences in survival for cancer patients treated with chemotherapy. Patients and methods: We genotyped a total of ﬁ ve polymorphisms in GSTM1 , GSTT1 , GSTP1 and GSTA1 genes in 159 patients with locally advanced breast cancer, treated with single-agent doxorubicin or docetaxel (Taxotere). Gene expression microarrays were performed in 67 breast tumor samples. We correlate this data with treatment outcome. Results: In multivariate analysis, patients homozygous GG for GSTP1 c.313A > G SNP had a lower risk of chemoresistance when treated with doxorubicin (odds ratio 0.106; con ﬁ dence interval 0.012 – 0.898; P = 0.040). No association was found in the docetaxel arm. Also, we found that GSTP1 expression varied signi ﬁ cantly among breast cancer molecular subtypes. Conclusions: GSTP1 may constitute another tool contributing to individualized anthracycline-based therapy.
Mediational Role of Phonological Awareness Skills in Phonological Working Memory, IQ and Reading Ability among Kindergarten Children’s

The present study was designed to examine the relationship between phonological working memory, IQ and reading ability, through the mediation phonological awareness skills. Two hundred kindergarten children‟s (100 boys & 100 girls; age ranged between 4 and 5 years) (M age =4.38), from 23 kindergartens attached to private schools in Muscat Governorate, Oman. The Phonological awareness skills was measured with “Phonological Awareness Test- Second Edition (PAT-2)” [34], the “Comprehensive Test of Phonological Processing (CTOPP-2)” and phonological working memory [35]. The IQ was measured by Otis Lennon [36]. Mediational path analysis supported our hypothesized model. Result indicate that phonological working memory indirectly links to the reading ability of children, through phonological awareness skills, there was no direct effect of intelligence on phonological awareness, It was conclude that Memory, who have higher use more phonological awareness skills and their children show higher reading ability.
The Asymmetric E ects of Uncertainty Shocks

This study evaluates the effects of financial uncertainty shocks in the US, investigating the role of the monetary policy stance. Estimating a nonlinear Vector Autoregressive, we find that an uncertainty shock triggers asymmetric and negative effects across the business cycle. The reactions of consumption and investments are state-dependent and drive the fluctuations of GDP. The variance of macroeconomic variables due to the shock is from four to six times larger in recessions than in normal times. A counterfactual exercise shows that the Balance Sheet-related monetary policy mitigates the persistence and the magnitude of the recessionary effects of the shock.
The Effect of Expectations and Service Quality on Customer Experience in the Marketing 3.0 Paradigm

The Marketing 3.0 era calls for a holistic approach to marketing practices, where value creation is driven by positive customer experiences that stimulate customer engagement and interaction. It is thus increasingly important for firms, particularly in the service sector, to improve customer experience to enhance value and brand success under this marketing paradigm. This study thus examined how customer expectations and perceived service quality influence multidimensional aspects of customer experience (cognitive, emotional, hedonic, and sensory) in the context of the airline service industry. Data was collected from 400 low-cost airline travellers in Malaysia and analysed with partial least squares structural equation modelling (PLS-SEM). The results show that both customer expectations and service quality have a significant positive effect on all dimensions of customer experience. The findings have important implications for marketing and consumer behaviour researchers as well as practitioners in the service sector.
RUNNING HEAD: RNAi for functional genomics in hexaploid wheat

Insertional mutagenesis and gene silencing are efficient tools for the determination of gene function. In contrast to gainor loss-of-function approaches, RNA interference (RNAi)-induced gene silencing can possibly silence multigene families and homoeologous genes in polyploids. This is of great importance for functional studies in hexaploid wheat where most of the genes are present in at least three homoeologous copies and conventional insertional mutagenesis is not effective. We have introduced into bread wheat dsRNA-expressing constructs containing fragments of genes encoding Phytoene Desaturase (PDS) or the signal transducer of ethylene Ethylene Insensitive 2 (EIN2). Transformed plants showed phenotypic changes that were stably inherited over at least two generations. These changes were very similar to mutant phenotypes of the two genes in diploid model plants. Quantitative real-time PCR revealed a good correlation between decreasing mRNA levels and increasingly severe phenotypes. RNAi silencing had the same quantitative effect on all three homoeologous genes. The most severe phenotypes were observed in homozygous plants which showed the strongest mRNA reduction and, interestingly, produced around two-fold the amount of small RNAs compared to heterozygous plants. This suggests that the effect of RNA interference in hexaploid wheat is gene-dosage dependent. Wheat seedlings with low mRNA levels for EIN2 were ethylene-insensitive. Thus, EIN2 is a positive regulator of the ethylene-signaling pathway in wheat, very similar to its homologs in Arabidopsis and rice. Our data show that RNA interference results in stably inherited phenotypes and therefore represents an efficient tool for functional genomic studies in polyploid wheat. www.plantphysiol. org on August 25, 2017 Published by Downloaded from Copyright © 2006 American Society of Plant Biologists. All rights reserved.
Optimal Organizational Structure

This paper is concerned with the relative eﬃciency of two organizational structures, which I call simple and complex. I model the organization as a communication network where the structure governs who communicates with whom. Workers receive a noisy signal, they meet a decision maker (DM) and communicate their information as a report. The DM must then estimate the true state of the world based on these reports. The clarity of the report is dependent on the length of the meeting and the communication ability of the worker. The DM is assumed to have a greater value of opportunity cost than the workers. I show that even in the absence of strategic incentives that diﬀerent communication structures can be preferred.
Lectures on N[x](p)

Introduction Definition of NX(p) : the a-ne case Definition of NX(p) : the scheme setting How large is NX(p) When p --> ? More properties of p NX(p) The Zeta Point of View Examples Examples Where Dim X(C) = 0 Examples Where Dim X(C) = 1 Examples Where Dim X(C) = 2 The Chebotarev Density Theorem for a Number Field The Prime Number Theorem for a Number Field Chebotarev Theorem Frobenian Functions and Frobenian Sets Examples of S-Frobenian Functions and S-Frobenian Sets Review of l-adic Cohomology The l-adic Cohomology Groups Artin's Comparison Theorem Finite FIelds : Grothendieck's Theorem The Case of a Finite Field : The geometric and The Arithmetic Frobenius The Case of a Finite Field : Deligne's Theorems Improved Deligne-Weil Bounds Examples Variation with p Auxiliary Results on Group Representations Characters with Few Values Density Estimates The Unitary Trick The l-adic Properties of NX(p) NX(p) Viewed as an l-adic Character Density Properties About NX(p) - NY (p) The Archimedean Properties of NX(p) The Weight Decomposition of the l-adic Character hX The Weight Decomposition : Wxamples and Applications The Sato-Tate Conjecture Equidistribution Statements The Sato-Tate Correspondence An l-adic Construction of the Sato-Tate Group Consequences of the Sato-Tate Conjecture Examples Higher Dimension: The Prime Number Theorem and the Chebotarev Density Theorem The Prime Number Theorem Densities The Chebotarev Density Theorem Proof of the Density Theorem Relative Schemes References Index of Notations Index of Terms
Radiative Cascade Repopulation of 1 s 2 s 2 p 4 P States Formed by Single Electron Capture in 2–18 MeV Collisions of C 4+ ( 1 s 2 s 3 S ) with He

: This study focuses on the details of cascade repopulation of doubly excited triply open-shell C 3 + ( 1 s 2 s 2 p ) 4 P and 2 P ± states produced in 2–18 MeV collisions of C 4 + ( 1 s 2 s 3 S ) with He. Such cascade calculations are necessary for the correct determination of the ratio R of their cross sections, used as a measure of spin statistics [Madesis et al. PRL 124 (2020) 113401]. Here, we present the details of our cascade calculations within a new matrix formulation based on the well-known diagrammatic cascade approach [Curtis, Am. J. Phys. 36 (1968) 1123], extended to also include Auger depopulation. The initial populations of the 1 s 2 sn (cid:96) 4 L and 1 s 2 sn (cid:96) 2 L levels included in our analysis are obtained from the direct n (cid:96) single electron capture (SEC) cross sections, calculated using the novel three-electron close-coupling (3eAOCC) approach. All relevant radiative branching ratios (RBR) for n ≤ 4 were computed using the COWAN code. While doublet RBRs are found to be very small, quartet RBRs are found to be large, indicating cascade feeding to be important only for quartets, consistent with previous ﬁndings. Calculations including up to third order cascades, extended to n → ∞ using an n − 3 SEC model, showed a ∼ 60% increase of the 1 s 2 s 2 p 4 P populations due to cascades, resulting, for the ﬁrst time, in R values in good overall agreement with experiment.
Recognition Memory: The Role of Recollection and Familiarity

Recognition memory is perhaps the simplest and most widely studied measure of episodic memory. Behavioral and neural studies have examined a variety of different types of recognition tasks and shown that recognition judgments can be based on two functionally and neurally separable processes (i.e., the recollection of qualitative or relational information about the study event, and assessments of item familiarity). In the current chapter we provide a brief review of the literature by considering the different types of recognition tests commonly used in studies of humans and rodents, we show why there is a need to include multiple point measures of recognition such as receiver operating characteristics, and we consider the evidence showing the separability of the different processes underlying recognition. We then consider the progress that has been made in behavioral studies characterizing the functional nature of those processes, as well as lesion and neuroimaging studies examining the role of different medial temporal lobe regions in supporting recognition judgments. The results of these studies have been important in assessing a number of competing theoretical claims about the processes underlying recognition, in characterizing memory changes in various conditions such as aging and amnesia, and in developing neurocomputational models of recognition and the medial temporal lobes. Moreover, these findings have been useful in revealing how different recognition processes are related to other cognitive functions such as those underlying emotion, implicit memory, working memory and perception.
A general framework for a Second Philosophy analysis of set-theoretic methodology

Penelope Maddy’s Second Philosophy is one of the most well-known approaches in recent philosophy of mathematics. She applies her second-philosophical method to analyze mathematical methodology by reconstructing historical cases in a setting of means-ends relations. However, outside of Maddy’s own work, this kind of methodological analysis has not yet been extensively used and an-alyzed. In the present work, we will make a ﬁrst step in this direction. We develop a general framework that allows us to clarify the procedure and aims of the Second Philosopher’s investigation into set-theoretic methodology; provides a platform to analyze the Second Philosopher’s methods themselves; and can be applied to further questions in the philosophy of set theory.
Gas exchange and yield of grafted yellow passion fruit under salt stress and plastic mulching 1

: Irrigation with saline water is one of the main factors that limit gas exchange and yield of yellow passion fruit in the semi-arid region of Brazil. The use of wild species of Passiflora ssp. tolerant to salinity as a rootstock and the application of mulching with plastic film can attenuate the effects of salt stress. The objective of present study was to evaluate the application of plastic film mulching and irrigation with saline water on the gas exchange and yield of yellow passion fruit grafted on P. cincinnata . The experiment was carried out under field conditions, from September 2019 to February 2021, in a 2 × (2 × 2) factorial scheme, in randomized blocks, in split plots and four replications. The treatments were related to irrigation with low-salinity (0.5 dS m -1 ) and high-salinity (4.5 dS m -1 ) water in yellow passion fruit plants, accession ‘Guinezinho’, propagated by seed and grafted on Passiflora cincinnata in the soil without and with plastic mulching. Irrigation with 4.5 dS m -1 water reduced gas exchange and yield of yellow passion fruit, but did not affect plants in the plastic mulched soil. Yellow passion fruit grafted on P. cincinnata showed increases in CO 2 assimilation rate, but it was not reflected in fruit yield. For cultivation under high salinity conditions (4.5 dS m -1 ), it is recommended to use yellow passion fruit propagated by seeds in the soil with plastic film mulching.
The Effect of Leadership Style on Employee’s Organizational Commitment: The Case of Wolaita and Dawro Zone Transport Private Limited Companies

This research study examines the relationship between transformational, transactional and laissez-faire leadership styles and three dimensions of organizational commitment affective, continuance and normative in Blata Abaya, Chebera Churchura and Fetane Transport Limited Companies. The Multifactor Leadership Questionnaire (MLQ) is used to measure transformational, transactional and laissez-faire leadership, while the three components Organizational Commitment Questionnaire (OCQ) is used to measure the three dimensions of organizational commitment such as affective, continuance and normative commitment. The researcher has employed quantitative survey research design. A sample of 6 leaders and 130 employees from selected Transport Limited Companies participated. One sample T test, Independent-sample T test, Pearson Correlation coefficient was employed for testing the relationship among variable and multiple regressions to infer the effect of leadership style on each dimensions of organizational commitment. The research findings from multiple regressions also revealed that transformational leadership has the strongest impact on affective commitment; transactional leadership also affects affective commitment. Transformational leadership also has a significant positive effect on normative commitment but not on continuance commitment. Transactional leadership also has a significant positive effect on both continuance and normative commitment. Laissez-faire leadership has no any significant effect on all dimension of organizational commitment. It is notified that the transformational leadership style is of further effect on the organizational commitment. The study recommends that even if it is not dominant behavior, managers of Blata Abaya, Chebera Churchura and Fetane Transport Limited Companies should minimize laissez-faire leadership behavior because it does not stimulate organizational commitment of their subordinates.
Basis of bene¢cial immunomodulation bymonoclonal antibodies

We previously identified five monoclonal antibodies (MAbs) against Streptococcus mutans adhesin P1 that modulate the humoral response when bound to whole bacteria and immune complexes (ICs) are administered to BALB/c mice. The two MAbs that redirected the response towards increased efficacy recognize discontinuous epitopes involving pre-alanine-rich domain sequence; therefore, to evaluate whether epitope specificity contributes to a desirable outcome a further MAb with this characteristic was tested. A beneficial immune response was promoted. None of the three MAbs that promoted a beneficial response was opsonic, suggesting that increased uptake of ICs by phagocytes does not mediate the improvement of the IC-elicited antibodies to inhibit bacterial adherence. Finally, two of the six antiP1 MAbs activated complement but did not partition according to desirable vs. nondesirable effects.
Open innovation and superior performance in SMEs: The mediating role of marketing capabilities and innovation

Even though many enterprises apply open innovation practices in the search for external sources of knowledge, this does not necessarily translate to improved performance. This issue is especially important for medium and small enterprises (SMEs) which need to expand their knowledge frontiers to survive and achieve superior performance. The objective of this research is to analyze the role of marketing capabilities and innovation in the relationship between open innovation and organizational performance. Using structural equation modeling, this research presents empirical evidence from 154 manufacturing SMEs. Research findings reveal that open innovation alone does not influence organizational performance, confirming that marketing capabilities and innovation play individual and sequential mediation roles in the relationship between open innovation and performance. From this, SME managers, in addition to looking for external knowledge, should develop marketing and innovation capabilities to capitalize this external knowledge and develop effective strategies to significantly impact performance.
Organizational Role Stress: Perceptions of Women Agricultural Assistants from Kerala

Stresses disrupt the physical or psychological functioning of individuals. Occupational Stress occurs in a reaction to events or situations in the work environment. Different studies have classified occupational stress in terms of different aspects such as physical environment, role stressors, organizational structure, job characteristics and professional relationships. Organizational Role Stress (ORS) is defined as the stress resulting from the occupation of an organizational role and performing or not being able to perform therein (Pareek.1983). The present study has been undertaken to understand the perceived organizational role stress by the women agricultural assistants from Kerala State Department of Agriculture. Expost- facto research design was followed in the study. A sample comprising of 120 women agricultural assistants were selected through multistage random sampling. Organizational role stress was measured using a Likert-type scale, which consisted of two broad groups of stressors namely family role stressor and work role stressors. The scale was pre-tested during pilot study and Cronbach’s alpha found to be 0.95 which was significant. The study found that except role erosion stressor, all other role stressors were at moderate or high level. Further, non-parametric two-way analysis showed that there was a highly significant difference between different stressors. Stress due to role overload followed by inter-role distance was the major problem with mean ranks 9.783 and 7.871 respectively.
Experience with low-energy gold-gold operations in RHIC during FY 2010

During Run-10, RHIC operated at several different Au-Au collision energies, as requested mainly by the STAR collaboration in a quest to search for the critical point in the QGP phase diagram. The center-of-mass energies {radical}s{sub NN} are listed in Table 1, together with the respective start and end dates and the duration of the respective run at each energy. While STAR defines 'low energy' as anything below {radical}s{sub NN} = 39 GeV, we focus in the scope of this paper on energies below the regular RHIC injection energy of {radical}s{sub NN} {approx} 20 GeV, since this energy regime is particularly challenging for stable RHIC operations. Figures 1 and 2 show the evolution of beam intensity and luminosity during the course of the {radical}s{sub NN} = 7.7 GeV and 11.5 GeV run. In the following sections we will recapitulate the modifications during the run that led to significant performance improvements, and summarize what was learned at the various energies for possible application in future runs.