Miracle-dz/UniFAR-FTUs huggingface dataset:
Multiple modifiable maternal, household and health service factors are associated with maternal nutrition and early breastfeeding practices in Burkina Faso

Abstract Low coverage of effective nutrition interventions in many high‐burden countries, due to service provision and demand factors, result in poor uptake of recommended practices and nutrition outcomes. We examined the factors that influence maternal nutrition and early breastfeeding practices and determined the extent that the key factors could improve these practices in two regions in Burkina Faso. We used household survey data among pregnant (n = 920) and recently delivered women (n = 1840). Multivariable regression analyses were conducted to identify the determinants of a diverse diet and iron‐folic acid (IFA) supplement consumption, weight monitoring during pregnancy and early initiation of breastfeeding (EIBF). Population attributable risk analysis was used to estimate how much the outcomes can be improved under optimal conditions of interventions that address the modifiable determinants. During pregnancy, 21% of women achieved minimum diet diversity (MDD‐W), 70% consumed 90+ IFA tablets and 65% were weighed 4+ times; EIBF was 40%. Nutrition knowledge was associated with MDD‐W (odds ratio [OR]: 3.2), 90+ IFA (OR: 1.5) and EIBF (OR: 1.9). Positive social norms and family support were associated with 90+ IFA (OR: 1.5). Early and 4+ ANC visits were associated with 90+ IFA (OR: 1.5 and 10) and 4+ weight monitoring (OR: 6.2). Nutrition counselling was associated with 90+ IFA (OR: 2.5) and EIBF (OR: 1.5). Under optimal programme conditions, 41% of women would achieve MDD‐W, 93% would consume 90+ IFA, 93% would be weighed 4+ times and 57% would practice EIBF. Strengthening the delivery and uptake of interventions targeted at these modifiable factors has the potential to improve maternal nutrition practices.
The Impact of Adhesions on Nasal Airflow: A Quantitative Analysis Using Computational Fluid Dynamics

Background Nasal adhesions (NAs) are a known complication of nasal airway surgery. Even minor NAs can lead to significant postoperative nasal airway obstruction (NAO). Division of such NAs often provides much greater relief than anticipated. Objective We examine the impact of NAs at various anatomical sites on nasal airflow and mucosal cooling using computational fluid dynamics (CFD) and multiple test subjects. Methods CT scans of healthy adult subjects were used to construct three-dimensional nasal airway computational models. A single virtual 2.5 mm diameter NA was placed at one of five sites commonly seen following NAO surgery within each nasal cavity bilaterally, resulting in 10 NA models and 1 NA-free control for each subject. CFD analysis was performed on each NA model and compared with the subject's NA-free control model. Results 4 subjects were recruited to create 44 computational models. The NAs caused the airflow streamlines to separate, leading to a statistically significant increase in mucosal temperature immediately downstream to the NAs (wake region). Changes in the mucosal temperature in the wake region of the NAs were most prominent in anteriorly located NAs with a mean increase of 1.62 °C for the anterior inferior turbinate NAs (P < .001) and 0.63 °C for the internal valve NAs (P < .001). Conclusion NAs result in marked disruption to airflow patterns and reduced mucosal cooling on critical surfaces, particularly in the wake region. Reduced wake region mucosal cooling may be a contributing factor to the exaggerated perception of nasal obstruction experienced by patients with NAs.
B-meson mixing from full lattice QCD with physical u, d, s and c quarks

We present the first lattice QCD calculation of the $B_s$ and $B_d$ mixing parameters with physical light quark masses. We use MILC gluon field configurations that include $u$, $d$, $s$ and $c$ sea quarks at 3 values of the lattice spacing and with 3 values of the $u/d$ quark mass going down to the physical value. We use improved NRQCD for the valence $b$ quarks. Preliminary results show significant improvements over earlier values.
First detection of oscillations in the Halo giant HD 122563: Validation of seismic scaling relations and new parameters

Aims. The nearby metal-poor giant HD 122563 is an important astrophysical laboratory in which to test stellar atmospheric and interior physics. It is also a benchmark star for which to calibrate methods to apply to large scale surveys. Recently it has been remeasured using various methodologies given the new high precision instruments at our disposal. However, inconsistencies in the observations and models have been found. Methods. In order to better characterise this star using complementary techniques we have been measuring its radial velocities since 2016 using the Hertzsprung telescope (SONG network node) in order to detect oscillations. Results. In this work we report the first detections of sun-like oscillations in this star, and to our knowledge, a detection in the most metal-poor giant to date. We applied the classical seismic scaling relation to derive a new surface gravity for HD 122563 of log gν = 1.39 ± 0.01. Reasonable constraints on the mass imposed by its PopII giant classification then yields a radius of 30.8 ± 1.0 ℛ⊙. By coupling this new radius with recent interferometric measurements we infer a distance to the star of 306 ± 9 pc. This result places it further away than was previously thought and is inconsistent with the HIPPARCOS parallax. Independent data from the Gaia mission corroborate the distance hypothesis (dGDR2 = 290 ± 5 pc), and thus the updated fundamental parameters. Conclusions. We confirm the validity of the classical seismic scaling relation for surface gravity in metal-poor and evolved star regimes. The remaining discrepancy of 0.04 dex between log gGDR2 (= 1.43 ± 0.03) reduces to 0.02 dex by applying corrections to the scaling relations based on the mean molecular weight and adiabatic exponent. The new constraints on the Hertzsprung–Russell diagram (L⋆ν = 381 ± 26 ℒ⊙) significantly reduce the disagreement between the stellar parameters and evolution models, however, a discrepancy of the order of 150 K still exists. Fine-tuned stellar evolution calculations show that this discrepancy can be reconciled by changing the mixing-length parameter by an amount (−0.35) that is in agreement with predictions from recent 3D simulations and empirical results. Asteroseismic measurements are continuing, and analysis of the full frequency data complemented by a distance estimate promises to bring important constraints on our understanding of this star and of the accurate calibration of the seismic scaling relations in this regime.
Effect of Extraction Time on Origanum onites L. Infusions and Essential Oils – Biological Evaluation, Statistical Principal Component and Hierarchial Cluster Analyses

Origanum onites L. of Lamiaceae, is used as a culinary spice and herbal tea; also for its antioxidant, antimicrobial effects among other activities and effects. This research aims to examine the in vitro antimicrobial and antioxidant activities of the infusions and the essential oils (EOs) obtained using different conditions from the aerial parts of the processed and raw of O. onites herbal material. The EOs from O. onites were distilled at different times and characterized both by GC‐FID and GC/MS systems. The resulting main compounds were identified as carvacrol (65.5–91 %), linalool (0.3–17.9 %), γ‐terpinene (2.8–4.6 %), and thymol (0.5–1.5 %), respectively. In addition, Origanum infusions were prepared at four different time intervals, where the volatile compounds of the infusions were analysed using the HS‐SPME‐GC/MS system. Statistical Principal Component (PCA) and Hierarchical Cluster Analyses (HCA) tools were used to demonstrate the composition variations on different times for O. onites infusion and EO samples.
22Ne and 23Na ejecta from intermediate-mass stars: the impact of the new LUNA rate for 22Ne(p,γ)23Na

We investigate the impact of the new LUNA rate for the nuclear reaction $^{22}$Ne$(p,\gamma)^{23}$Na on the chemical ejecta of intermediate-mass stars, with particular focus on the thermally-pulsing asymptotic giant branch (TP-AGB) stars that experience hot-bottom burning. To this aim we use the PARSEC and COLIBRI codes to compute the complete evolution, from the pre-main sequence up to the termination of the TP-AGB phase, of a set of stellar models with initial masses in the range $3.0\,M_{\odot} - 6.0\,M_{\odot}$, and metallicities $Z_{\rm i}=0.0005$, $Z_{\rm i}=0.006$, and $Z_{\rm i} = 0.014$. We find that the new LUNA measures have much reduced the nuclear uncertainties of the $^{22}$Ne and $^{23}$Na AGB ejecta, which drop from factors of $\simeq 10$ to only a factor of few for the lowest metallicity models. Relying on the most recent estimations for the destruction rate of $^{23}$Na, the uncertainties that still affect the $^{22}$Ne and $^{23}$Na AGB ejecta are mainly dominated by evolutionary aspects (efficiency of mass-loss, third dredge-up, convection). Finally, we discuss how the LUNA results impact on the hypothesis that invokes massive AGB stars as the main agents of the observed O-Na anti-correlation in Galactic globular clusters. We derive quantitative indications on the efficiencies of key physical processes (mass loss, third dredge-up, sodium destruction) in order to simultaneously reproduce both the Na-rich, O-poor extreme of the anti-correlation, and the observational constraints on the CNO abundance. Results for the corresponding chemical ejecta are made publicly available.
Reduction in sound discrimination in noise is related to envelope similarity and not to a decrease in envelope tracking abilities

Humans and animals constantly face challenging acoustic environments, such as various background noises, that impair the detection, discrimination and identification of behaviourally relevant sounds. Here, we disentangled the role of temporal envelope tracking in the reduction in neuronal and behavioural discrimination between communication sounds in situations of acoustic degradations. By collecting neuronal activity from six different levels of the auditory system, from the auditory nerve up to the secondary auditory cortex, in anaesthetized guinea‐pigs, we found that tracking of slow changes of the temporal envelope is a general functional property of auditory neurons for encoding communication sounds in quiet conditions and in adverse, challenging conditions. Results from a go/no‐go sound discrimination task in mice support the idea that the loss of distinct slow envelope cues in noisy conditions impacted the discrimination performance. Together, these results suggest that envelope tracking is potentially a universal mechanism operating in the central auditory system, which allows the detection of any between‐stimulus difference in the slow envelope and thus copes with degraded conditions.
Multisymplectic effective general boundary field theory

The transfer matrix in lattice field theory connects the covariant and the initial data frameworks; in spin foam models, it can be written as a composition of elementary cellular amplitudes/propagators. We present a framework for discrete spacetime classical field theory in which solutions to the field equations over elementary spacetime cells may be amalgamated if they satisfy simple gluing conditions matching the composition rules of cellular amplitudes in spin foam models. Furthermore, the formalism is endowed with a multisymplectic structure responsible for local conservation laws. Some models within our framework are effective theories modeling a system at a given scale. Our framework allows us to study coarse graining and the continuum limit.
Chemotherapy plus panitumumab/cetuximab versus chemotherapy plus bevacizumab in wild-type KRAS/RAS metastatic colorectal cancer: a meta-analysis

ABSTRACT Objective It remains controversial which targeted monoclonal antibodies combined with chemotherapy can provide better efficacy in wild-type KRAS/RAS metastatic colorectal cancer (mCRC) patients. Therefore, we used this meta-analysis to assess the latest evidence of clinical outcomes. Materials and methods We systematically searched PubMed, Web of Science, Cochrane Library and Embase databases for eligible studies published from database inception to May 2022. RevMan 5.4 was used to conduct the meta-analysis. Results 11 RCTs involving a total of 3575 patients were included. Meta-analysis showed that EGFR inhibitors significantly prolonged the overall survival (OS) [HR = 0.83, 95%CI (0.73, 0.94), P = 0.003] and overall response rate (ORR) [RR = 1.11, 95%CI (1.05, 1.18), P = 0.0003] compared to VEGF inhibitors in wild-type KRAS/RAS mCRC patients, but no significant difference in progression-free survival (PFS) [HR = 0.96, 95%CI (0.87, 1.07), P = 0.50]. In subgroup analysis, the survival benefit of EGFR inhibitors was limited to first-line treatment. Conclusion Our study showed that EGFR inhibitors were superior to VEGF inhibitors in wild-type KRAS/RAS mCRC patients, especially in patients with first-line treatment. However, subsequent large sample, multi-center RCTs are needed to further verify our conclusions.
Artificial intelligence-generated hip radiological measurements are fast and adequate for reliable assessment of hip dysplasia

Aims Hip dysplasia (HD) leads to premature osteoarthritis. Timely detection and correction of HD has been shown to improve pain, functional status, and hip longevity. Several time-consuming radiological measurements are currently used to confirm HD. An artificial intelligence (AI) software named HIPPO automatically locates anatomical landmarks on anteroposterior pelvis radiographs and performs the needed measurements. The primary aim of this study was to assess the reliability of this tool as compared to multi-reader evaluation in clinically proven cases of adult HD. The secondary aims were to assess the time savings achieved and evaluate inter-reader assessment. Methods A consecutive preoperative sample of 130 HD patients (256 hips) was used. This cohort included 82.3% females (n = 107) and 17.7% males (n = 23) with median patient age of 28.6 years (interquartile range (IQR) 22.5 to 37.2). Three trained readers’ measurements were compared to AI outputs of lateral centre-edge angle (LCEA), caput-collum-diaphyseal (CCD) angle, pelvic obliquity, Tönnis angle, Sharp’s angle, and femoral head coverage. Intraclass correlation coefficients (ICC) and Bland-Altman analyses were obtained. Results Among 256 hips with AI outputs, all six hip AI measurements were successfully obtained. The AI-reader correlations were generally good (ICC 0.60 to 0.74) to excellent (ICC > 0.75). There was lower agreement for CCD angle measurement. Most widely used measurements for HD diagnosis (LCEA and Tönnis angle) demonstrated good to excellent inter-method reliability (ICC 0.71 to 0.86 and 0.82 to 0.90, respectively). The median reading time for the three readers and AI was 212 (IQR 197 to 230), 131 (IQR 126 to 147), 734 (IQR 690 to 786), and 41 (IQR 38 to 44) seconds, respectively. Conclusion This study showed that AI-based software demonstrated reliable radiological assessment of patients with HD with significant interpretation-related time savings. Cite this article: Bone Jt Open 2022;3(11):877–884.
A SPECTACULAR OUTFLOW IN AN OBSCURED QUASAR

SDSS J1356+1026 is a pair of interacting galaxies at redshift z = 0.123 that hosts a luminous obscured quasar in its northern nucleus. Here we present two long-slit Magellan LDSS-3 spectra that reveal a pair of symmetric ∼10 kpc size outflows emerging from this nucleus, with observed expansion velocities of ∼250 km s−1 in projection. We present a kinematic model of these outflows and argue that the deprojected physical velocities of expansion are likely ∼1000 km s−1 and that the kinetic energy of the expanding shells is likely 1044–45 erg s−1, with an absolute minimum of >1042 erg s−1. Although a radio counterpart is detected at 1.4 GHz, it is faint enough that the quasar is considered to be radio quiet by all standard criteria, and there is no evidence of extended emission due to radio lobes, whether aged or continuously powered by an ongoing jet. We argue that the likely level of star formation is insufficient to power the observed energetic outflow and that SDSS J1356+1026 is a good case for radio-quiet quasar feedback. In further support of this hypothesis, polarimetric observations show that the direction of quasar illumination is coincident with the direction of the outflow.
The magnetic field in the X-ray corona of Cygnus X-1

The different electron distributions in the hard and soft spectral states (HS and SS) of BH binaries could be caused by kinetic processes and changing because of varying physical conditions in the corona. In presence of a magnetic field in the corona, the electron distribution can appear thermal, even when acceleration mechanisms would produce non thermal distributions. This is due to fast and efficient thermalization through synchrotron self-absorption. We have analyzed data from 6 years of observations of Cygnus X-1 with the INTEGRAL observatory and produced 12 high-quality, stacked broad-band hard X-ray spectra representative of the whole range of spectral shapes observed. We then fit these spectra with hybrid thermal/non-thermal Comptonization models and study the evolution of the physical parameters of the accretion flow across the spectral transition. In particular, we use the BELM model to constrain the magnetic field in the corona through its effects on the coronal emission. Indeed, the hot electrons of the X-ray corona produce soft (optical-UV) synchrotron radiation which is then Comptonized and may affect the temperature of the electrons through Compton cooling. We find that in the SS, the emission is dominated by Comptonization of the disc photons and the magnetic field is at most of the order of 1E+06 G. In the hard states, the data are consistent with a pure synchrotron self-Compton model. If the non-thermal excess observed above a few hundred keV in the HS is produced in the same region as the bulk of the thermal Comptonization, we obtain an upper limit on the coronal magnetic field of about 1E+05 G. If, on the other hand, the non-thermal excess is produced in a different location, the constraints on the magnetic field in the HS are somewhat relaxed and the upper limit rises to 1E+07 G. We discuss these constraints in the context of current accretion flow models.
CONCEPT - The COsmological $N$-body CodE in PyThon

CO$N$CEPT (COsmological $N$-body CodE in PyThon) is a free and open-source code for cosmological $N$-body simulations on massively parallel computers with distributed memory. Collisionless dark matter is the only implemented particle species. Gravity can be computed using the PP, PM or the P$^{3}$M algorithm. The goal of CO$N$CEPT is to make it pleasant to work with cosmological $N$-body simulations - for the cosmologist as well as for the source code developer. This is the user guide. The source code and additional documentation can be found at this https URL
SELECTION EFFECTS IN GAMMA-RAY BURST CORRELATIONS: CONSEQUENCES ON THE RATIO BETWEEN GAMMA-RAY BURST AND STAR FORMATION RATES

Gamma-ray bursts (GRBs) visible up to very high redshift have become attractive targets as potential new distance indicators. It is still not clear whether the relations proposed so far originate from an unknown GRB physics or result from selection effects. We investigate this issue in the case of the LX– (hereafter LT) correlation between the X-ray luminosity LX(Ta) at the end of the plateau phase, Ta, and the rest-frame time . We devise a general method to build mock data sets starting from a GRB world model and taking into account selection effects on both time and luminosity. This method shows how not knowing the efficiency function could influence the evaluation of the intrinsic slope of any correlation and the GRB density rate. We investigate biases (small offsets in slope or normalization) that would occur in the LT relation as a result of truncations, possibly present in the intrinsic distributions of LX and . We compare these results with the ones in Dainotti et al. showing that in both cases the intrinsic slope of the LT correlation is ≈ − 1.0. This method is general and therefore relevant for investigating whether or not any other GRB correlation is generated by the biases themselves. Moreover, because the farthest GRBs and star-forming galaxies probe the reionization epoch, we evaluate the redshift-dependent ratio Ψ(z) = (1 + z)α of the GRB rate to the star formation rate. We found a modest evolution −0.2 ⩽ α ⩽ 0.5 consistent with a Swift GRB afterglow plateau in the redshift range 0.99 < z < 9.4.
Early diagnosis of hepatic inflammation in Japanese nonalcoholic fatty liver disease patients using 3D MR elastography

The damping ratio (DR) and the loss modulus (G″) obtained by 3D MR elastography complex modulus analysis has been reported recently to reflect early intrahepatic inflammation, and is expected to be a noninvasive biomarker of inflammation in nonalcoholic fatty liver disease (NAFLD). However, the role of the DR and the G″ in Japanese NAFLD patients remains unclear.
The Prognostic Value of Preoperative Serum D-dimer Levels After Surgical Resection of Thymic Epithelial Tumors

Introduction Thymic epithelial tumors are the most common mediastinal tumors. Despite the high survival rate after surgery, some patients still require postoperative adjuvant therapy and closer follow-up. Hematological indicators such as biochemical routines and coagulation indicators have been reported to be independently associated with the prognosis of various malignancies. Therefore, we included hematological indicators in the analysis. Methods The data of 105 patients with thymic epithelial tumors were retrospectively collected from Sun Yat-sen University Cancer Center, and the patients with missing preoperative hematological indicators were excluded. X-tile software was used to obtain the best cutoff value of each preoperative hematological indicator, and COX regression analysis and Kaplan-Meier survival curves were used to demonstrate statistically significant results. Results COX univariate regression analysis of all patients showed that Masaoka stage, T stage, WHO histologic types, D-dimer, albumin-fibrinogen ratio (AFR), Fibrinogen (Fbg) were associated with postoperative overall survival (P < .05). T stage, WHO histologic types, D-dimer, and AFR were associated with postoperative recurrence-free survival (P < .05). Finally, multivariate regression analysis showed that T stage, D-dimer levels were independently associated with postoperative overall survival (OS) and recurrence-free survival (RFS) in patients with thymic epithelial tumors. Conclusions For thymic epithelial tumors, higher preoperative D-dimer levels predict poorer survival and shorter recurrence-free survival. This may help guide postoperative adjuvant therapy and follow-up patterns in patients with thymic epithelial tumors.