Miracle-dz/UniFAR-FTUs huggingface dataset:
‘Skeletal Age’ for mapping the impact of fracture on mortality

Objectives: to propose a novel "Skeletal Age" metric as the age of an individual's skeleton resulting from a fragility fracture to convey the combined risk of fracture and fracture-associated mortality for an individual with specific risk profile. Design: a retrospective population-based cohort study. Setting: hospital records from the Danish National Hospital Discharge Register that includes the whole-country data of all contacts to health care system. Participants: 1,667,339 adults in Denmark born on or before 1 January 1950, who were followed up to 31 December 2016 for incident low-trauma fracture and mortality. Main outcome measures: fracture and chronic diseases recorded within 5 years prior to the index fracture were identified using ICD-10 codes. Death was ascertained from the Danish Register on Causes of Death. We used Cox's proportional hazards regression to estimate the hazard ratio of mortality following a fracture, and then used the Gompertz law of mortality to transform the hazard ratio into life expectancy for a specific fracture site. The difference between life expectancy associated with a fracture and background population life expectancy is regarded as the years of life lost. Skeletal age is then operationally defined as an individual's current age plus the years of life lost. Results: during a median follow-up of 16.0 years, 95,372 men and 212,498 women sustained a fracture, followed by 41,017 and 81,727 deaths, respectively. A fracture was associated with 1 to 4 years of life lost dependent on fracture site, gender and age, with the greater loss being observed in younger men with a hip fracture. Hip, proximal and lower leg fractures, but not distal fractures, were associated with a substantial loss in life expectancy. A 60-year-old man with a hip fracture is expected to have a skeletal age of 66.1 years old (95% CI: 65.9, 66.2). Conclusion: we propose to use skeletal age as a metric to assess fracture risk for an individual and thus improve doctor-patient risk communication.
Trends in the distribution of body mass index, waist circumference and prevalence of obesity among Taiwanese adults, 1993–2016

Background Differences in the prevalence of general and abdominal obesity by subgroups such as age, sex, and education have been reported worldwide. Most studies in Taiwan regarding obesity prevalence were targeted at school-aged children or without further stratification by subgroups. Our aim was to examine the age-specific secular trend of body mass index (BMI), waist circumference (WC), and obesity prevalence stratified by sex, education and urbanization levels in Taiwanese adults. Methods We used three waves of nationally representative population from the Nutrition and Health Survey in Taiwan (NAHSIT) 1993–1996 (n = 2 989), 2005–2008 (n = 2 495), and 2013–2016 (n = 2 880). The data included standardized measurement of body weight, height, and WC. We conducted a serial cross-sectional analysis among adults aged 20 years or above to examine the age-specific trends of BMI, WC, and the prevalence of underweight, overweight, general obesity, and abdominal obesity with stratification by sex, education, and urbanization levels. Results The general obesity prevalence was 16%, 21%, and 20% and the abdominal obesity prevalence was 27%, 42%, and 47% in the 1993–1996, 2005–2008, and 2013–2016 surveys, respectively. The age-specific secular trend of BMI differed across subgroups; however, the trend of WC increased rapidly regardless of subgroups, except for women aged ≥60 years. The general obesity prevalence increased noticeably among men, younger- and middle-age adults with high school or higher education, middle- and older-age adults with lower than high school education, people <39 and ≥50 years of age residing in rural areas, and among those between 30 and 59 and ≥70 years of age residing in urban areas. Conclusions Although the increasing trend of general obesity prevalence was levelling off among several subgroups, the abdominal obesity prevalence increased significantly and rapidly in Taiwan. Future research in developing effective weight and WC control interventions tailored to different subgroups is urgently needed.
Causal illusion in the core of pseudoscientific beliefs: The role of information interpretation and search strategies

The prevalence of pseudoscientific beliefs in our societies negatively influences relevant areas such as health or education. Causal illusions have been proposed as a possible cognitive basis for the development of such beliefs. The aim of our study was to further investigate the specific nature of the association between causal illusion and endorsement of pseudoscientific beliefs through an active contingency detection task. In this task, volunteers are given the opportunity to manipulate the presence or absence of a potential cause in order to explore its possible influence over the outcome. Responses provided are assumed to reflect both the participants’ information interpretation strategies as well as their information search strategies. Following a previous study investigating the association between causal illusion and the presence of paranormal beliefs, we expected that the association between causal illusion and pseudoscientific beliefs would disappear when controlling for the information search strategy (i.e., the proportion of trials in which the participants decided to present the potential cause). Volunteers with higher pseudoscientific beliefs also developed stronger causal illusions in active contingency detection tasks. This association appeared irrespective of the participants with more pseudoscientific beliefs showing (Experiment 2) or not (Experiment 1) differential search strategies. Our results suggest that both information interpretation and search strategies could be significantly associated to the development of pseudoscientific (and paranormal) beliefs.
Association between retinitis pigmentosa and an increased risk of primary angle closure glaucoma: A population-based cohort study

Background Retinitis pigmentosa (RP) is the most frequent retinal hereditary dystrophy and result in blindness if progresses. Several case reports have revealed the possible association between RP and primary angle-closure glaucoma (PACG). We conducted a population-based study to explore whether RP significantly increased the risk of PACG development. Methods Using the Taiwan National Health Insurance Research Database, we enrolled patients with RP into the RP group from 2001 to 2013 and included a comparison group of 1:4 age- and sex-matched individuals without RP. We performed a Cox regression analysis to estimate the crude and adjusted hazard ratios (HRs) of RP for PACG after adjustment for hypertension, diabetes, hyperlipidaemia, chronic kidney disease, and lens subluxation. Results We enrolled 6223 subjects with RP and 24892 subjects for comparison. The mean age of the cohort was 49.0 ± 18.1 years. The RP group had significantly higher percentages of diabetes mellitus, hypertension, and hyperlipidaemia. The cumulative incidence of PACG in patients with RP was 1.61%, which was significantly higher than that in the comparison group (0.81%, p < 0.0001). According to the univariate Cox regression analysis, the hazard of PACG development was significantly greater in the RP group, with an unadjusted HR of 2.09 (95% confidence interval [CI], 1.64–2.65). The increased risk persisted after adjusting for confounders (adjusted HR = 2.18; 95% CI, 1.76–2.72). Conclusion This nationwide population-based cohort study showed that people with RP are at a significantly greater risk of developing PACG than individuals without RP.
Experimental study of water migration characteristics in compacted loess subjected to rainfall infiltration

In order to study the effect of the rainfall infiltration on water migration in compacted loess, a model device was developed for testing water migration in the soil under rainfall conditions. In this study, the volumetric water content and resistivity of soil were introduced into the model test device. This model test device was applied to the study of water migration characteristics in compacted loess under different rainfall conditions. The results show that the resistivity decreases with the increase of the volumetric water content at the same depth of the loess column. In this way, the characteristics of the water migration can also be reflected from the change of the resistivity. There is an intimate relationship between the resistivity and volumetric water content, dry density. The volumetric water content and dry density are normalized by saturation of loess, arriving the equation of saturation against the resistivity. The characteristics of rainfall infiltration in compacted loess show a particular pattern, which demonstrates that, with the increase of dry density of the loess column, the rainfall infiltration line present “Y”, “D” and “Λ” shape distribution respectively, under light rain, heavy rain and rainstorm.
Is maternal defensiveness of Gyr cows (Bos taurus indicus) related to parity and cows’ behaviors during the peripartum period?

The maternal care of cows can influence both the milk production and the performance of their calves, making this a topic of important relevance for the production industry that uses zebu cattle. The aims of this study were to 1) investigate the effects of parity on the behaviors of Gyr cows during the peripartum period; 2) characterize the maternal defensiveness of primiparous and multiparous cows towards handlers during the first handling of their calves; and 3) evaluate the relationships between cows’ behaviors at the peripartum period and maternal defensiveness. Thirty-one Gyr cows (primiparous and multiparous), from Empresa de Pesquisa Agropecuária de Minas Gerais (Brazil), were used. The animals were placed in a maternity paddock monitored by video cameras. The behaviors of the animals were collected in four periods: Pre-calving, Post-calving, First handling of calf and Post-handling. Primiparous cows presented more pain signs, reflected in arched spine (P = 0.05), and tended to move more (P = 0.07) than the multiparous in the Pre-calving period. Trends were observed for both Maternal Composite Score (P = 0.06) and Maternal Protective Behavior score (P = 0.06), indicating that both primiparous and multiparous were protective, but only multiparous cows were aggressive toward the caretakers on the first handling of their calves. The most protective cows spent more time eating during the prepartum period (P = 0.03), while the least attentive cows spent more time lying down (P = 0.02) in the prepartum period. The cows who nursed and stimulated their calves more were also calmer (P = 0.02) and more attentive (P = 0.01). In conclusion, the peripartum behaviors of Gyr cows were related to maternal care and maternal defensiveness. Multiparous cows tended to be more aggressive than primiparous cows at the time of the first handling of their calves.
Basic personal values in the midst of the COVID-19 pandemic in Italy: A two-wave longitudinal study

This study investigated value change during two phases of the COVID-19 pandemic in Italy, one of the most affected countries in the world. The first wave of data was collected in summer 2020, when the virus was on the retreat. The second wave was collected in autumn, at the peak of the second pandemic wave (November 2020). We investigated how Schwartz’s higher-order values changed over the two waves of the study, using economic condition as a predictor of change. We also examined whether value change predicted subsequent value-expressive behavior. Results showed no mean-level change for self-enhancement, self-transcendence, conservation, and openness to change values, but significant interindividual differences in the amount of change for each of the four values. Economic condition emerged as a significant predictor of change in conservation values: Individuals with a decreasing income since the beginning of the pandemic were more likely to increase the importance assigned to these values with respect to individuals whose economic well-being has remained unchanged. Moreover, an increase in conservation and openness to change values predicted behaviors that are mostly expressive of these values, above and beyond value importance at Time 1. Results and their implications for the study of values are discussed.
Whole genome sequence analysis of two subspecies of Companilactobacillus Futsaii and experimental verification of drug resistance and effect on the exploratory behavior of mice based on unique gene

This study characterized the whole genome of Companilactobacillus futsaii subsp. chongqingii CQ16Z1 isolated from Chongqing of China, performed genome sequence analysis with Companilactobacillus futsaii subsp. futsaii YM0097 isolated from Taiwan of China, and experimentally verified drug resistance and effect on the exploratory behavior of male C57BL/6 mice and analysis of gut microbiota and metabolomic studies. The genome of CQ16Z1 is 2.6 Mb. Sequence analysis between genomes showed that the two strains are Companilactobacillus futsaii. The unique genes of CQ16Z1 and YM0097 are 217 and 267, which account for 9% and 11% of the whole genomes, respectively. According to unique gene annotation, the results showed that genes associated with carbohydrate metabolism, environmental information processing, metabolism of cofactors and vitamins, cell wall/membrane/envelope biogenesis, phage and drug resistance are significantly different. The results of the drug resistance experiment showed that YM0097 had different degrees of resistance to 13 antibiotics, while CQ16Z1 was sensitive to more than half of them. YM0097 contains 9 prophage regions and CQ16Z1 contains 3 prophage regions. The results of the open field test showed that the time (P = 0.005; P = 0.047) and distance (P < 0.010; P = 0.046) of the central area of Y97 group and CQ group are significantly different from the control group. The results of the elevated plus maze test showed that compared with the control group, Y97 group had significant differences in the number of entries to the open arms and the percentage of open arms entry times (P = 0.004; P = 0.025), while the difference between the CQ group and the control group was not significant. YM0097 has a more obvious effect on the exploratory behavior of mice. The effects of YM0097 and CQ16Z1 on the intestinal flora of mice are also different. YM0097 may be more beneficial to the intestinal flora of the host. And LC/MS also showed that the metabolic effects of the two strains on the host are different. Finally, we believe that YM0097 is more suitable for application research as a psychobiotics.
Procalcitonin as a predictive marker in COVID-19: A systematic review and meta-analysis

Background Coronavirus disease 2019 has emerged as a global pandemic causing millions of critical cases and deaths. Early identification of at-risk patients is crucial for planning triage and treatment strategies. Methods and findings We performed this systematic review and meta-analysis to determine the pooled prognostic significance of procalcitonin in predicting mortality and severity in patients with COVID-19 using a robust methodology and clear clinical implications. Design We used Preferred Reporting Items for Systematic Reviews and Meta-Analyses and Cochrane Handbook for Systematic Reviews of Interventions guidelines. We included thirty-two prospective and retrospective cohort studies involving 13,154 patients. Results The diagnostic odds ratio of procalcitonin for predicting mortality were estimated to be 11 (95% CI: 7 to 17) with sensitivity, specificity, and summary area under the curveof 0.83 (95% CI: 0.70 to 0.91), 0.69 (95% CI: 0.58 to 0.79), and 0.83 (95% CI: 0.79 to 0.86) respectively. While for identifying severe cases of COVID-19, the odds ratio was 8.0 (95% CI 5.0 to 12.0) with sensitivity, specificity, and summary area under the curve of 0.73 (95% CI 0.67 to 0.78), 0.74 (0.66 to 0.81), and 0.78 (95% CI 0.74 to 0.82) respectively. Conclusion Procalcitonin has good discriminatory power for predicting mortality and disease severity in COVID-19 patients. Therefore, procalcitonin measurement may help identify potentially severe cases and thus decrease mortality by offering early aggressive treatment.
Changes in physical activity and sedentary time in United States adults in response to COVID-19

Physical activity is associated lower risk for a broad range of non-communicable diseases and early mortality, and even small changes in daily activity levels could have a profound effect on public health at the population level. The COVID-19 pandemic reshaped daily life for United States (US) adults resulting in reductions in physical activity early in the pandemic, but its longer-term effects on daily activities are unknown. To examine the longer-term impact of the pandemic on daily activity levels, we conducted a nationwide longitudinal study of 1,635 adults (20–75 years) in AmeriSpeak. Previous-day recalls of time-use, sedentary time, and physical activity were completed on randomly selected days in Fall 2019 (pre-pandemic) and Fall 2020. Overall, US adults reported less time in transportation (-0.47 hrs/d), more total discretionary time (0.40 hrs/d), but no changes in total sedentary time (0.10 hrs/d) or leisure-time physical activity (-0.06 hrs/d). Women reported significantly less total activity (-0.36 hrs/d) and participants with children < 13 yrs reported more sedentary time (0.60 to 0.82 hrs/d) and less moderate-to-vigorous intensity activity (-0.84 to -0.72 hrs/d). Adults without children reported no changes in sedentary time (0.02 hrs/d) or moderate-vigorous intensity activity (-0.06 hrs/d). Adults who started working from home reported no changes in physical activity, but they were among the most sedentary and least active population groups at both timepoints. Our findings describe the complex inter-play between competing behaviors as time-use demands have changed in response to the pandemic, particularly for adults with younger children. Many US adults are likely to continue working from home; therefore, implementation of evidence-based approaches to increase physical activity and reduce sedentary time in this growing population subgroup appears warranted.
Body mass index and physical frailty among older Mexican Americans: Findings from an 18-year follow up

Purposes The relationship between body mass index (BMI) and frailty in older Mexican Americans has not been previously studied. The objective of this study was to examine the relationship between BMI and frailty among non-frail older Mexican Americans at baseline over 18 years of follow up. Methods Longitudinal population-based study of 1,648 non-institutionalized Mexican Americans aged ≥ 67 years from the Hispanic Established Population for the Epidemiologic Study of the Elderly (1995/96-2012/13). Frailty phenotype was defined as meeting three or more of the following: unintentional weight loss of >10 pounds, weakness, self-reported exhaustion, low physical activity, and slow walking speed. BMI (kg/m2) was classified as underweight (<18.5), normal weight (18.5-<25), overweight (25-< 30), obesity category I (30-<35), and obesity category II/morbid obesity (≥35). Covariates included socio-demographics, comorbidities, cognitive function, and depressive symptoms. Generalized Estimating Equation models were performed to estimate the odds ratio (OR) and 95% confidence interval (CI) of frailty as a function of BMI category. Results Participants with underweight or obesity category II/ morbid obesity had greater odds of frailty over time compared to those with normal weight (OR = 2.39, 95% CI = 1.29–4.44 and OR = 1.62, 95% CI = 1.07–2.44, respectively) after controlling for all covariates. Participants with BMIs in the overweight or category I obesity were at lower odds of frailty over time. Conclusions Mexican American older adults with BMIs in the underweight or obesity category II/morbid obesity were at higher odds of frailty over time. This indicates that maintaining a healthy weight in this population may prevent future frailty.
Towards gender-inclusive job postings: A data-driven comparison of augmented writing technologies

Job advertisements are often worded in ways that might pose discrimination risks leading to the exclusion of certain groups of applicants, particularly in relation to their gender. Especially in male-dominated professions or leadership roles, the specific linguistic formulation of job postings acquires relevance if more women are to be attracted to apply. Various technologies have emerged that offer automated text screening, some of them even suggesting alternative formulations to increase gender inclusivity. In this study we analyze four software providers on the German market using a corpus of ∼160, 000 job ads from three different platforms. We identify the relevant social psychological research on gender and language that is at the scientific core of these technologies. We show that, despite sharing a common foundation, the four tools assess the potential for exclusion in job postings in a considerably divergent way on multiple levels of comparison. We discuss the levers in the software pipeline of all four technologies, as well as the potential effect of certain implementation decisions, such as string-based vs. semantic approaches to computational processing of natural language. We argue that the ‘technological translation’ of research is extremely involved and further studies of its use in practice are needed to assess the potential for more gender equality.
Influence of pharmacists and infection control teams or antimicrobial stewardship teams on the safety and efficacy of vancomycin: A Japanese administrative claims database study

Introduction Methicillin-resistant Staphylococcus aureus (MRSA) has a high mortality and requires effective treatment with anti-MRSA agents such as vancomycin (VCM). Management of the efficacy and safety of VCM has been implemented with the assignment of pharmacists in hospital wards and the establishment of teams related to infectious diseases. However, there are no reports evaluating the association between these factors and the efficacy and safety of VCM in large populations. Methods This study used the Japanese administrative claims database accumulated from 2010 to 2019. The population was divided into two groups, therapeutic drug monitoring (TDM) group and non-TDM group, and adjusted by propensity score matching. We performed multivariate logistic regression analysis to determine the influence of pharmacists and infection control teams or antimicrobial stewardship teams on acute kidney injury (AKI) and 30-day mortality. Results The total number of patients was 73 478 (TDM group, n = 55 269; non-TDM group, n = 18 209). After propensity score matching, 18 196 patients were matched in each group. Multivariate logistic regression analysis showed that pharmacological management for each patient contributed to the reduction of AKI (odds ratio [OR]: 0.812, 95% confidence interval [CI]: 0.723‒0.912) and 30-day mortality (OR: 0.538, 95% CI: 0.503‒0.575). However, the establishment of infectious disease associated team in facilities and the assignment of pharmacists in the hospital wards had no effect on AKI and 30-day mortality. In addition, TDM did not affect the reduction in AKI (OR: 1.061, 95% CI: 0.948‒1.187), but reduced 30-day mortality (OR: 0.873, 95% CI: 0.821‒0.929). Conclusion Pharmacologic management for individual patients, rather than assignment systems at facilities, is effective to reduce AKI and 30-day mortality with VCM administration.