Miracle-dz/UniFAR-FTUs huggingface dataset:
Curriculum Innovations: A Podcast-Based Neurologic Emergency Flipped Classroom Curriculum for Neurology Residents

Education on the management of neurologic emergencies is vital for neurology residents, and effective educational methods are needed. This study aims to implement and evaluate the impact of a podcast-based flipped classroom curriculum in neurologic emergencies. “Flipped classroom” instructional methods have been used in GME and informed by experiential learning theory.The objectives of this curriculum were to (1) compare the clinical phenomena discussed in the neurologic emergencies podcast(s) with your own clinical experience; (2) discuss the pitfalls in the management of the neurologic emergencies discussed in the podcast(s); and (3) develop a management plan for the neurologic emergencies discussed in the podcast(s). At 10 neurology residency programs, we implemented a 3-session flipped classroom curriculum covering topics in acute stroke, movement disorder emergencies, and status epilepticus. Each session consisted of aNeurology® podcast followed by content discussion with a clinical expert. Assessment of the curriculum included presession and postsession surveys focused on learners' confidence and attitudes toward podcast-based education.Our data sample consisted of survey responses from residents, with response volumes ranging from 29-111 across all surveys. Podcasts are already highly used by neurology residents in their self-directed education. Confidence increased among learners in the management of movement disorder emergencies (18% confident before vs 79% confident after,p< 0.001) and status epilepticus (72% confident before vs 91% confident after,p= 0.014) among those who completed the curriculum. A change in confidence in acute stroke management was not found (p= 0.15). Podcasts were consistently preferred over lectures and reading-based instructional methods while less preferred compared with simulation-based learning and case-based discussion with faculty. The podcast-based curriculum studied here showed high levels of enjoyment and perceived utility.We present a 3-part curriculum to help build learners' familiarity and confidence in 3 neurologic emergency categories. The educational impact is established in Level 1 of the Kirkpatrick paradigm. Future studies can explore a higher-level impact of this curriculum. Evolution in neurology education is shifting increasingly toward immediately accessible information via digital media. This curriculum can be useful to neurology educators who need to be increasingly agile and facile with multiple educational techniques to meet learners' needs.
Using Relative and Absolute Measures for Socioeconomic Inequalities in Health: Experiences from a Retrospective Cohort Study on COVID-19

Background: One approach to reducing the burden of diseases can be to identify socioeconomically vulnerable groups. We aimed to estimate the socioeconomic inequality of in-hospital deaths using relative and absolute indices of socioeconomic inequality. Methods: In this retrospective cohort study on Covid-19 patients; age, gender, marital status, education level, date of admission, diagnostic method, and final condition were measured. Socioeconomic inequality in inhospital death was assessed using three approaches. We used the relative index of inequality (RII) to measure relative inequality. We used two approaches to evaluate absolute inequality: the slope index of inequality (SII) and the concentration index (ci). Results: Overall, 587 patients’ data were collected and 42 (7.2%) of these patients died in the hospital. There were statistically significant differences between the case-fatality rates of different levels of education (P<0.001). In addition, all the inequality indices showed that the distribution of COVID-19-related deaths was higher among the lower education levels. Accordingly, after controlling the effect of age, gender, and comorbidities the RII indicated that the case fatality rate in the lowest education level was 9.42 (95% CI: 2.23 to 39.01, P<0.001) times compared to the case fatality rate in the highest level of education. Conclusion: The results of all three approaches indicate considerable education inequality in CFR in favor of groups of high education levels. These results can improve the prioritization and impact of public health interventions, including prevention and diagnosis of Covid-19 in favor of vulnerable groups.
Identification of Multiview Gene Modules Using Mutual Information-Based Hypograph Mining

Detection of gene-modules is one of the fundamental tasks for the integral analysis of network architecture. In this paper, we propose a novel algorithm using an integrated approach comprising statistical method and normalized mutual information-based hypograph mining for discovering the multiview co-similarity gene modules contained in multiview datasets. For this purpose, we first identify the statistically significant genes corresponding to each data profile and subsequently obtain the union set consisting of all these statistically significant genes. For each data profile, we then propose a new similarity score called as integrated normalized mutual information to obtain the similarity scores across all possible pairs of genes belonging to the union set by employing the results of gene clustering obtained through applying normalized mutual information-based graph clustering on the corresponding data profile. Moreover, we propose a new information theoretic measure called as multiview normalized mutual information to integrate all the similarity scores of a given gene-pair obtained across all the data profiles. For the experiment, we utilize one of the recently used multiview dataset named TCGA acute myeloid leukemia dataset comprising five different categories of data profiles. Furthermore, the co-similarity strengths of all the multiview gene modules obtained using the proposed method (PM) are reported. Finally, we provide a comparative study between the proposed and other existing methods for demonstrating the superiority of the PM over others. Code is available in http://ieeexplore.ieee. org.
Conditional extreme value analysis for random vectors using polar representations

In this thesis we contribute to the extreme value theory by deriving conditional limit statements for bivariate random vectors with polar representations given that one component becomes extreme. Our results extend the class of elliptical and generalized distributions for which the conditional extreme value theory could be applied. For this purpose we propose a new geometric approach which permits deeper understanding of existing results and gives opportunities for our further interesting generalizations. Moreover, we deduce limit theorems for dependent polar components which are of much importance for applications.
Finite left neofields and their use as a unifying principle in constructions for orthogonal Latin squares

One of the outstanding problems in the study of Latin squares is that of improving the known lower bounds for N(n), the maximum number of Latin squares of order n in a mutually orthogonal set. After describing the methods of construction which attain the best known lower bounds for N(n), n < 32 and showing how most of these are interrelated we provide a general method of construction for sets of mutually orthogonal Latin squares (m.o.l.s.) from left neofields. We then give detailed information about the structure of all isomorphically distinct left neofields of order less than ten and about the m.o. l.s. which they produce, and summarised information for orders up to fourteen. We further show that many of the previously known constructions of m.o. l.s. effectively employ the construction which we describe, in particular the recent constructions of three m.o. l.s. of order fourteen and four of order twenty. In the course of this investigation it is noted that the number of complete mappings of both of the non-cyclic abelian groups of order eight is the same. Furthermore, it is found that both of the non-abelian groups of order eight possess the same number of complete and near complete mappings. We explain and justify why this is the case. In our study of left neofields we discuss the properties of sequenceability and R-sequenceability of groups. At the end of the thesis, we discuss a related question, raised by R. L. Graham, as to which groups are r-set-sequenceable. This is solved for abelian groups except that, for r = n - 1, the question is reduced to that of asking which abelian groups are R-sequenceable.
The cloning and expression of the two types of kisspeptin gene in hard-lipped barb (Osteochilus vittatus)

Abstract. Prayogo NA, Rahayu SC, Sugito PPA, Meyanadewi SB, Sukardi P, Rositas RE, Bessho Y. 2023. The cloning and expression of the two types of kisspeptin gene in hard-lipped barb (Osteochilus vittatus). Biodiversitas 24: 2797-2804. Hard-lipped barb (Osteochillus vittatus Valenciennes, 1842) is a native Indonesian species with many benefits for economic, aquaculture, and environmental sustainability. Several studies showed that the species had high reproductive potential, with kisspeptin gene playing a role in reproductive hormone production and GnRH secretion. Kisspetin gene is also important for gonad maturation in fish. Therefore, this study aimed to determine the structure of Kiss-1 and Kiss-2 genes, as well as the expression of the kisspeptin gene in the hypothalamus and gonads in each phase of female hard-lipped barb development.The study procedure involved several stages, including organ preparation, isolation, sequence identification, and measurement of cGnRH gene expression. The structure of Kiss-1 gene in hard-lipped barb was obtained, and the nucleotide sequence had a product length of 213, coding for 89 amino acids. Meanwhile, Kiss-2 consisted of 230 nucleotides, coding for 76 amino acids, and the sequences observed had 70-80% with other fish species. The results showed that the expression values of Kiss-1 and Kiss-2 genes in the hypothalamus were higher compared to the gonads, with the lowest in the adult phase and the highest in the Juvenile phase. This information will lead us to use the kisspeptin gene to increase hard-lipped barb reproduction.
Trajectory of Depressive Symptoms in the Context of Romantic Relationship Breakup: Characterizing the “Natural Course” of Response and Recovery in Young Adults

Young adults face stressful role transitions as well as increased risk for poor mental health, but little is known about a “natural course” of response to such events. We used the PHQ-2 to characterize the trajectory of depressive symptoms before, during, and after relationship breakup and examined subjective appraisal and sense of control as moderators. In our sample of participants reporting a single breakup during the 2-year study period (N = 156), breakup was associated with a temporary increase in depressive symptoms that returned to pre-breakup levels within 3 months. We observed increased symptoms among negatively appraised, but not positive or neutral, events. A general low sense of control was associated with higher depressive symptoms at all time points. Our results suggest that a natural course of response to young adult breakups is characterized by recovery within 3 months and that subjective appraisal and sense of control contribute to this adaptive response.
Motivation to Read and Parental Support: Implications to the Grade Six Student’s Reading Comprehension

Any Filipino child with sufficient reading motivation and parental support would have greater chances of success in school. This descriptive correlational study sought to determine if there is an association among the participants’ reading comprehension level, their level of motivation to read, and the extent of their parents’ support in reading. Fifty (50) Grade 6 pupils from a public school in the division of Misamis Oriental were the participants. Researcher-made and validated instruments were utilized to gather the data. The research instruments were pilot tested on 30 pupils in a nearby school which yielded reliable results in terms of its Cronbach Alpha. Descriptive statistics and Spearman Rho were used to analyze the gathered data. The study revealed that the participants’ level of motivation to read and the extent of their parental support were generally high. The reading comprehension level in all components, identifying the main idea and key details, sequencing a passage into an ordinal series, making inferences, and identifying unfamiliar vocabulary was fair. Data also showed that the participants’ motivation for reading and the extent of parental support is not significantly associated with their reading comprehension skills. The results point to the need for teachers and educational leaders to design appropriate, effective, and research-based interventions to arrest the low reading comprehension performance of the students.
The economic growth effects of foreign direct investment in developing countries, 1980–2019

Abstract The foreign investment and economic growth relationship in developing countries have attracted considerable attention in comparative international sociology. However, despite nearly fifty years of research, this relationship is still not well understood. I bring new cross-national evidence to bear upon this issue with analyses that improve upon previous research on the foreign direct investment and economic growth nexus in developing countries. I analyze cross-national longitudinal data using panel regression models with fixed effects and instrumental variables to account for possible endogeneity. Foreign capital penetration appears to be positively associated with economic growth in developing countries, which supports the expectations of neoclassical economic theory. Rather than critiquing any particular theoretical paradigm, this research hopefully serves to help reinvigorate scholarly discussion amongst comparative international social scientists regarding the economic growth effects of foreign direct investment in developing countries.
Potentials of Iron Oxide Nanoparticles (Fe3O4): As Antioxidant and Alternative Therapeutic Agent Against Common Multidrug-Resistant Microbial Species

For the treatment of pathogenic bacterial infections, multidrug resistance (MDR) has become a major issue. The use of nanoparticles is a promising strategy for combating medication resistance in a variety of pathogens that cause deadly diseases. The goal of our research was to extract multidrug-resistant bacteria from wound infections and then use iron oxide nanoparticles (Fe3O4) as alternative therapeutic agents in vitro. Gram staining, morphological attributes evaluation, and biochemical testing were used to assess the microbes. The Kirby-Bauer disk diffusion method was used to test MDR-bacterial strains against several antibiotics; the majority of these isolates were resistant to ceftazidime, amoxicillin, Gentamicin, and tetracycline. the iron oxide nanoparticles were produced by the co-precipitation method and were confirmed by changing the color to dark black as well as the Scanning Electron Microscope (SEM) and Transmission Electron Microscope (TEM) analysis that shows the shape and average size between (29.03-56.54) nm. The highest effect of iron oxide nanoparticles (Fe3O4) on the growth of Proteus.mirabilis (P.mirabilis) was as it was found that the average diameter of the inhibition zone was 22.66±1.15 mm, followed by Staphylococcus.epidermidis (S.epidermidis), Acinetobacter.baumannii (A.baumannii) with the average diameter of the inhibitory zone it was 21.66±1.52 mm, 20.33±1.53 mm respectively, and Candida.albicans (C.albicans) was 18.33±1.15 mm at 100 µgmL-1 (stock). The synthesized iron oxide nanoparticles (Fe3O4) are used to capture rapidly microbes under the magnetic field effect. The antioxidant activity DPPH of the iron oxide nanoparticles (Fe3O4) showed 29.3%, 42.2%, 58.6%, 67.4%, and 74 % at a concentration (6.25, 12.5, 25, 50, 100) µgmL-1 respectively, it demonstrated that the scavenging percentage increase with increasing the iron oxide nanoparticles (Fe3O4) concentrations.
Simultaneous equidistributing and non-dense points for non-commuting toral automorphisms

We show in prime dimension that for two non-commuting totally irreducible toral automorphisms the set of points that equidistribute under the first map but have non-dense orbit under the second has full Hausdorff dimension. In non-prime dimension the argument fails only if the automorphisms have strong algebraic relations.
Possible Influence of Extreme Magnetic Storms on the Thermosphere in the High Latitudes

Solar and interplanetary events can create extreme magnetic storms, such as the Carrington storm in 1859 with intensity up to Dst ∼−1,760 nT. The influence of an idealized, smaller Carrington‐type storm on the thermosphere has been simulated using the nonhydrostatic Global Ionosphere‐Thermosphere Model. For the storm conditions we simulated, the solar wind BZ and velocity were −50 nT and 1,000 m/s, respectively. The corresponding cross polar cap potential reached 360 kV, and the hemispheric power was 200 GW. Consequently, the hemispheric integrated Joule heating exceeded 3,500 GW, which is more than 70 times higher than normal conditions. The thermosphere variations at high latitudes were examined through the comparison of three cases: reference, storm with geomagnetic energy enhancement only, and storm with both solar and geomagnetic energy enhancement. At 400‐km altitude, the neutral density increased by >20 times at certain locations and by >10 times globally averaged. The atmosphere experienced a temperature of 4000 K, more than 1,500 m/s horizontal wind, and exceeding 150 m/s vertical wind. In general, additional energy increase from solar irradiation resulted in 20–30% more perturbation in neutral density and temperature. The exobase (top boundary of the thermosphere) expanded to altitudes >1,000 km, and the buoyancy acceleration (difference between vertical pressure gradient force and gravity force) can be as large as 3 m/s2. The results will help to determine possible extreme responses to interplanetary coronal mass ejections for various phenomena occurring in geospace.
The Risk of Ischemic and Hemorrhagic Stroke in Head and Neck Cancer: A Longitudinal Cohort Study

Simple Summary Several previous studies have shown that head and neck cancer may be associated with an increased risk of ischemic stroke but not hemorrhagic stroke. However, whether head and neck cancer causes an increased risk of developing ischemic or hemorrhagic strokes remains unclear. We found that patients with head and neck cancer had a significantly increased risk of overall and ischemic stroke development, although there was no significant difference in the incidence and risk ratio of hemorrhagic stroke. However, in the subgroup analysis, patients with oral cavity cancer had a significantly increased risk of both ischemic and hemorrhagic strokes compared to the general population. These findings suggest that clinicians should carefully monitor the development of stroke when they follow head and neck cancer survivors. Abstract Several studies have shown that head and neck cancer is associated with an increased risk of stroke incidence. However, investigations of the association between the two diseases based on a matching cohort dataset are still limited. Therefore, we identified the incidence and risk of stroke in patients with head and neck cancer using a nationwide population-based cohort dataset. A total of 5248 individuals without cancer and 1312 with cancer were enrolled from the dataset after a 4:1 propensity score matching. We found that the incidence of overall stroke (per 1000 person years) was 19.29 for those with head and neck cancer, consisting of 17.32 as ischemic type and 2.74 as hemorrhagic type. Additionally, patients with head and neck cancer had a significantly increased risk of overall and ischemic stroke development but not hemorrhagic stroke. Moreover, the risk of stroke development over time was relatively high within the first year after the diagnosis of head and neck cancer. However, in the subgroup analysis, oral cavity cancer survivors showed an increased risk of both ischemic and hemorrhagic strokes. Therefore, our nationwide population-based cohort study suggests that clinicians should closely monitor patients with head and neck cancers for the early detection of stroke.
A continuation method for rigid‐cohesive fracture in a discontinuous Galerkin finite element setting

An energy minimization formulation of initially rigid cohesive fracture is introduced within a discontinuous Galerkin finite element setting with Nitsche flux. The finite element discretization is directly applied to an energy functional, whose term representing the energy stored in the interfaces is nondifferentiable at the origin. Unlike finite element implementations of extrinsic cohesive models that do not operate directly on the energy potential, activation of interfaces happens automatically when a certain level of stress encoded in the interface potential is reached. Thus, numerical issues associated with an external activation criterion observed in the previous literature are effectively avoided. Use of the Nitsche flux avoids the introduction of Lagrange multipliers as additional unknowns. Implicit time stepping is performed using the Newmark scheme, for which a dynamic potential is developed to properly incorporate momentum. A continuation strategy is employed for the treatment of nondifferentiability and the resulting sequence of smooth nonconvex problems is solved using the trust region minimization algorithm. Robustness of the proposed method and its capabilities in modeling quasistatic and dynamic problems are shown through several numerical examples.
The Effect Number of Replication and the Number of Option Scale toward the Reliability Coefficient of Maximal in the Rubric Assessment of Vocational Learning Outcome

This study aims to determine the effect of number of replication and the number of option scale toward the maximal reliability coefficient in the assessment instrument rubric. This research used experimental method. The population is all students of state vocational high school of food processing technology of Cianjur in the 2014/2015 academic year. This research used t-test analysis. The result of the research shows that maximal reliability coefficient is higher with more and more option scale on instrument of rubric. Number of data replication has an effect on maximal reliability coefficient. The maximal reliability coefficient gets higher with more and more data replication on instrument of.
Opportunity Set, Liquidity, Stock Return, Inflation As A Moderator Investment Risk, Investment

This study aims to analyze the influence of liquidity of investment risks, opportunities on stock return with inflation as a moderator. These study was a quantitative study which invloving panel data method. In thid study, data processing and population studies using Eviews software which consist of companies in the banking sector listed on the Indonesia Stock Exchange. This study found that investment risk has no impact on equity returns, the level of investment opportunity is locked into equity returns, liquidity has a significant negative impact on equity returns, and inflation affects the ratio of investment risk to equity returns was found to have the potential to increase Inflation weakens the relationship between investment opportunities and equity returns, while inflation can strengthen the relationship between liquidity and equity returns. It is hoped that further researchers will be able to include these variables as consideration in doing such investigation.