Miracle-dz/UniFAR-FTUs huggingface dataset:
OTT_A_228702 435..450

Muhammad Zubair Saleem 1 Muhammad Azhar Nisar 1 Mohammed Alshwmi Syed Riaz Ud Din Yaser Gamallat 1 Muhammad Khan 3 Tonghui Ma 1College of Basic Medical Sciences, Dalian Medical University, Dalian, Liaoning 116044, People’s Republic of China; 2Department of Clinical Laboratory, The First Affiliated Hospital of Dalian Medical University, Dalian Medical University, Dalian, Liaoning 116044, People’s Republic of China; 3Department of Zoology, University of the Punjab, Lahore, Punjab 54590, Pakistan Purpose: Breast cancer is the most common malignancy among women across the globe. Despite concerted efforts to improve the prevailing treatment modalities, the overall prognosis of breast cancer remains unsatisfactory. Recently, antiproliferative activity of Brevilin A (Brv-A), a sesquiterpene lactone compound of Centipeda minima, has been unveiled in various cancer types. Here, we have explored anticancer activity of Brv-A in MCF-7 breast carcinoma cells by targeting various pathways. Materials and Methods: Cell proliferation rate was determined by CCK-8 and clonogenic assay. Cellular morphological changes were observed under phase contrast microscope while calcein-AM and PI was used for live/dead assay. Cell cycle assay was performed by flow cytometry. Apoptotic cell percentage was determined by Hoechst 33258 staining and flow cytometric analysis. ROS generation and mitochondrial membrane potential were measured using commercially available kits while protein expression was measured by Western blotting. Results: In our study, Brv-A exerted antiproliferative effect through mitotic arrest at G2/M phase of cell cycle and induced apoptosis in MCF-7 cells in a dose-dependent manner. Induction of apoptosis by Brv-Awas found to be associated with ROS generation by targeting NOX2 and NOX3, mitochondrial dysfunction (MMP dissipation and Bcl-2 family proteins modulation), DNA fragmentation, JNK and p38 MAPK activation, endoplasmic reticulum (ER) stress by increasing Bip/GRP78, ATF4 and CHOP protein expressions and inhibition of STAT3 activation via decreased phosphorylation of JAK2 and SRC. Pretreatment of NAC, a ROS scavenger, partially reversed the aforesaid cellular events indicating ROS generation as the primary event to modulate cellular targets for induction of apoptosis. Besides, Brv-A has also been documented for inhibition of cell migration via decrease in COX-2 and MMP-2 expression. Conclusion: Taken together, Brv-A induces G2/M phase arrest, ROS-dependent apoptosis, ER stress, mitochondrial dysfunction and inhibits STAT3 activation in MCF-7 cells signifying it to be one of the potential anticancer therapeutics in future.
Fertility dynamics in France and Italy. Who are the couples that do not give birth to the intended child?

France and Italy lie at the two extremes as regards fertility levels in Europe. Although previous findings showed that desired fertility is very similar in France and Italy, an examination of intentions to have a child in the following three years points to a country-specific difference. Namely, in France reproductive intentions are higher than in Italy for all parities. Moreover, since the actual fertility levels are so different, there could be some sorts of constraints that limit fertility more strongly in Italy than in France. Taking advantage of the first two rounds of the French and Italian Gender and Generation Surveys, in this paper we aim at highlighting the profiles of those couples who do not realize their intended fertility projects in the two countries considered. This line of reasoning may provide important input to policy makers wishing to lift the constraints to fertility realization.
Routing Protocol for Heterogeneous Wireless Sensor Networks Based on a Modified Grey Wolf Optimizer

Wireless sensor network (WSN) nodes are devices with limited power, and rational utilization of node energy and prolonging the network lifetime are the main objectives of the WSN’s routing protocol. However, irrational considerations of heterogeneity of node energy will lead to an energy imbalance between nodes in heterogeneous WSNs (HWSNs). Therefore, in this paper, a routing protocol for HWSNs based on the modified grey wolf optimizer (HMGWO) is proposed. First, the protocol selects the appropriate initial clusters by defining different fitness functions for heterogeneous energy nodes; the nodes’ fitness values are then calculated and treated as initial weights in the GWO. At the same time, the weights are dynamically updated according to the distance between the wolves and their prey and coefficient vectors to improve the GWO’s optimization ability and ensure the selection of the optimal cluster heads (CHs). The experimental results indicate that the network lifecycle of the HMGWO protocol improves by 55.7%, 31.9%, 46.3%, and 27.0%, respectively, compared with the stable election protocol (SEP), distributed energy-efficient clustering algorithm (DEEC), modified SEP (M-SEP), and fitness-value-based improved GWO (FIGWO) protocols. In terms of the power consumption and network throughput, the HMGWO is also superior to other protocols.
Geoaddit ive Smal l Area Model for the Est imat ion of Consumpt ion Expenditure in A lbania

In the last few years the demand of spatially detailed statistical data is considerably increased due also to the development of statistical methods for small area. In the past, the high degree of spatial detail of such information was not so useful for practical purposes as firms and local authorities were interested in information aggregated at some pre-specified level. However, the area definition and the assignment of the data to appropriate areas can pose problems in the estimation process. In particular, in small area estimation the importance of this matter is represented by the fact that some parameters of the model can be related to the between-area relationships. Geoadditive models can face this problem analyzing directly the spatial distribution of the study variable while accounting for possible covariate effects. This paper presents the implementation of a geoadditive model to small area estimation. The geoadditive SAE model is apply in order to estimate the district level mean of the household log per-capita consumption expenditure for the Republic of Albania.
Who Benefits from Corporate Social Responsibility

Firms often donate a share of profits to charity as a form of Corporate Social Responsibility (CSR) to attract and retain talent. Previous studies suggest that such initiatives can motivate workers to work harder in lieu of higher wages, generating benefits for both sides of the labor market. We design a novel version of a commonly used experiment to control for self-selection and find that wages remain the most effective incentives to attract and motivate workers, with corporate donations playing a smaller role than previously suggested. We also show that when firms donate a share of profits to charity, they reduce wages to keep their profits constant, negatively affecting workers’ earnings. Our results reveal that CSR initiatives can be at best marginally beneficial for firms, but considerably costly for workers.
Post Purchase Cognitive Dissonance: Impact of Product Involvement, Impulse Buying and Hedonic Consumption Tendencies

This study proposed and empirically verified the impact of product involvement, hedonic consumption tendencies and impulse buying tendencies on cognitive dissonance. Analyses of a sample of 422 students, drawn from different universities of twin cities, revealed interesting findings. Hedonic consumption tendencies was found insignificant in predicting cognitive dissonance but product involvement and impulse buying were significant in predicting cognitive dissonance being former having inverse relation and latter having direct relation. Further to this, impact of product involvement and hedonic consumption tendencies were found directly relational to impulse purchase. Product category wise exploration of this model can add new dimensions and findings in future.
A review of design intelligence: progress, problems, and challenges

Design intelligence is an important branch of artificial intelligence (AI), focusing on the intelligent models and algorithms in creativity and design. In the context of AI 2.0, studies on design intelligence have developed rapidly. We summarize mainly the current emerging framework of design intelligence and review the state-of-the-art techniques of related topics, including user needs analysis, ideation, content generation, and design evaluation. Specifically, the models and methods of intelligence-generated content are reviewed in detail. Finally, we discuss some open problems and challenges for future research in design intelligence.
Multiple-antenna techniques in nonorthogonal multiple access: a review

As a promising physical layer technique, nonorthogonal multiple access (NOMA) can admit multiple users over the same space-time resource block, and thus improve the spectral efficiency and increase the number of access users. Specifically, NOMA provides a feasible solution to massive Internet of Things (IoT) in 5G and beyond-5G wireless networks over a limited radio spectrum. However, severe co-channel interference and high implementation complexity hinder its application in practical systems. To solve these problems, multiple-antenna techniques have been widely used in NOMA systems by exploiting the benefits of spatial degrees of freedom. This study provides a comprehensive review of various multiple-antenna techniques in NOMA systems, with an emphasis on spatial interference cancellation and complexity reduction. In particular, we provide a detailed investigation on multiple-antenna techniques in two-user, multiuser, massive connectivity, and heterogeneous NOMA systems. Finally, future research directions and challenges are identified.
Comparison of Fine Needle Aspiration Cytology (FNAC) and Trucut biopsy in evaluation of suspicious palpable breast lesions

Objective: To evaluate the direct comparison of Fine Needle Aspiration Cytology (FNAC) with tru-cut breast biopsy in palpable suspicious breast lesions. Methodology: This study was conducted in surgical unit Hayatabad Medical Complex, Peshawar, Pakistan from January 2012 to December 2013. All female patients of age above 20 years with clinically palpable lump were included in the study. Both FNAC and tru-cut biopsy were performed simultaneously in the same setting and the results were compared with final histopathology as gold standard. Results: A total of 65 patients were evaluated. Mean age of the patients was 39.33±13.52 years. The overall sensitivity of FNAC was 94.9% and that of the trucut biopsy 100%. The specificity for malignancy was 88.2% and 93.5% for FNAC and tru-cut biopsy, respectively. Conclusion: Although FNAC is a useful and rapid method for evaluating any palpable breast lump, tru-cut biopsy was more sensitive and specific. Tru-cut biopsy had potential benefits for histological diagnosis and information about tumor type, grade, receptor status and use of any neo-adjuvant therapy for breast lesion.
Experimental Investigation of Scour Hole Characteristics for Different Shapes of Piers Caused by Flood Hydrograph Succeeding Steady Flow

In this study, the scour depth and dimensions of the scour hole around different shaped piers in the case of hydrographs succeeding steady flow were studied experimentally. The experiments were carried out by using circular, square, rectangular, lenticular and rectangular with trapezoidal nose to compare the various scour hole geometries at the same flow conditions. Numerous experiments were conducted in a rectangular flume (18.6 m long, 0.80 m wide and 0.75 m deep) with different triangular shaped hydrographs. The flume bed of 26 cm thickness consists of uniform graded material with D 50 =1.68 mm. The experiments were carried out in clear water conditions. The temporal variations of the equilibrium scour depths in front the pier and the scour hole dimensions were recorded by two different cameras. The equilibrium scour depths at lateral sides and downstream of the piers were also measured. Regression analysis was performed in order to derive empirical relations to predict temporal variations of the scour depth in the case of unsteady flow. The shape factor values were also investigated based on the experimental findings and the obtained values were compared with those available in literature. The performance of the obtained empirical relations was tested by using experimental data existing in the literature. The smallest scour hole was observed for the rectangular with trapezoidal noses pier. The increase in the scour hole dimensions for other cross-sections was in the following order: rectangular with circular noses, circular, square and rectangular piers.
Spatiotemporal Variations In Agricultural Flooding In Middle and Lower Reaches of Yangtze River From 1970 to 2018

Agricultural floods in the middle and lower reaches of the Yangtze River, known as the “land of fish and rice” in China, have increased both in areal coverage and frequency over the past 50 years, presenting a grave challenge to sustainable development and food security in the region. Studying the spatiotemporal variation characteristics of agricultural floods in this region is thus important for providing a scientific basis for regional flood control and disaster mitigation. We used variation trend analyses, Mann–Kendall tests, wavelet analyses, and center of gravity modeling to study spatiotemporal changes in agricultural floods in the study area, based on agricultural flood indicators. Changes in agricultural flood frequency showed an overall increasing trend. The frequency of floods changed abruptly in 1990, with the average frequency of floods per station increasing by 0.2086/year from 1991 through 2018, characterized by multiple time-scale changes. The time scale of 17 years had three low–high cycles, that of eight years had six, and that of four years had 13. Agricultural floods in the study area were concentrated in the southern Yangtze River and mainly occurred in northeastern Jiangxi Province and the southeastern Zhejiang Province. The area with high agricultural flood indices increased. Agricultural floods were closely related to the Yangtze River and the direction of the gravity center of agricultural floods was similar to that of the river. Affected by precipitation intensity and frequency, the gravity center fluctuated greatly and generally alternated from southwest to northeast.
Particulate Matter and Its Impact on Mortality among Elderly Residents of Seoul, South Korea

Climate change, air pollution, and the rapidly aging population are important public health challenges. An understanding of air pollution impacts is imperative for preventing air-pollution-related deaths and illnesses, particularly in vulnerable subgroups such as the increasing population of older adults. To assess the effects of short-term air-pollution exposure on the elderly, we conducted a time-series analysis (1996–2015) of the associations between particulate matter with an aerodynamic diameter of <10 μm (PM10) and deaths among elderly residents of Seoul, South Korea, which has a rapidly aging population. We also investigated the synergistic effects of temperature and the lag structures of the effects by sex, cause of death, and season. A 10 μg/m3 rise in the 4-day moving average concentration of PM10 was associated with 0.31% (95% confidence interval (CI): 0.18% to 0.44%), 0.32% (95% CI: 0.09% to 0.55%), and 0.22% (95% CI: –0.23% to 0.66%) increases in non-accidental, cardiovascular, and respiratory mortalities, respectively. We found a significant and strong synergistic effect of PM10 concentration and ambient temperature on mortality in elderly people. PM10 posed an increased risk of non-accidental or cardiovascular mortality with increasing temperature, whereas the associated risk of respiratory death was highest on very cold days. The shape and length of the lag structure varied with the cause of death, sex, and season. Results indicate that elderly people exposed to PM10 are at increased risk of premature death. In the near future, these risks are likely to increase in step with the temperature rise associated with climate change and the continued population aging. Stronger emission controls will be needed to minimize the increased health risks associated with air pollution, especially in regions with high populations of elderly individuals.
Systematic Review of Sustainable-Development-Goal Deployment in Business Schools

In 2015, more than 190 countries pledged to meet by 17 sustainable development goals (SDGs) by 2030 that aim to ensure sustainable global social and economic development, and to strengthen universal peace. Public institutions, businesses, organizations and individuals are all called upon to contribute to this challenge. Focusing on business schools (BSs), and the potential impact they have on graduates, we ask what they are doing for the deployment of these objectives. To this end, we conducted a systematic review of the literature related to SDGs and business schools in the WOS, SCOPUS and ERIC databases. A multi-stage exclusion process resulted in 16 documents for review. The findings of this study provide key information on the role that business schools have to play in achieving SDGs and the ways in which they can be incorporated into their activity: from more in-depth actions linked to creating awareness, questioning current paradigms, fostering cooperation and interdisciplinarity with stakeholders, and working on coherence; to more specific interventions such as creating student associations, incorporating new teaching methodologies or increasing students’ participation in extracurricular activities. In addition, this study also allows us to identify gaps in the literature, giving ideas on necessary future lines of research.
Role of SME in Poverty Alleviation in SAARC Region via Panel Data Analysis

The key objective of the formation of the South Asian Association of Regional Cooperation (SAARC) is to join hands collectively for slow economic growth, poverty eradication, deprived health and education sectors. In the 12th SAARC Summit, it has been declared that poverty eradication is the main area of concentration and SAARC countries would strive their best to minimize all types of poverty with the help of any possible strategy. The main objectives of the current study are to evaluate the development of the agenda of poverty eradication in SAARC countries through small and medium enterprise (SME) development because it would be considered as a short-routed remedy to mitigate poverty. The poorest 20% income holder as a percentage of GDP has been used as the proxy for poverty in the SAARC region. SME development has been measured through the SME share in GDP in respective countries. The panel dataset has been developed for the period of 1990 to 2015. The fixed effect method (FEM) and regression equation techniques were used to analyse the observed data. The results of the FEM were misleading. The regression equations for the respective countries were used for empirical analysis. The results have identified that there are three main factors that are essential in reducing poverty in the SAARC region: SME growth, openness of trade and social sector development.
VILNIUS UNIVERSITY ALBERTAS ZINEVIČIUS CURVES OVER NUMBER FIELDS AND THEIR RINGS OF INTEGERS Docotoral dissertation Physical sciences, mathematics (01P)

In this document, the author collected his work that ranges through the years 2006−2013. The common theme that occurs in its five parts is that of families of algebraic curves defined over the rational numbers with points over a number field or over its ring of integers. In the first part, average number of rational points of small height on hyperelliptic curves of fixed genus is described. In the second part, this result is extended to describing how often, on average, values of homogeneous polynomials at pairs of small coprime integers are values of a given univariate polynomial with integer coefficients. Further, small families of curves that are defined over the rational numbers and do not have points over a given number field are constructed. In the subsequent part, congruent number curves are investigated. It is shown that, given a cyclic number field K, at least half of the prime numbers p that remain inert in K correspond to curves 16p = x − y that do not have nontrivial points over the ring of integers of K. In the last part, a short exposition to a classical technique of showing that a particular curve does not have integral points is given.
Influence of Financial Architecture on Financial Performance and Corporate Value in the Indonesian Capital Market

Bu calisma, finansal mimarinin Endonezya Sermaye Piyasasi'ndaki finansal performans ve kurumsal deger uzerindeki etkisini incelemeyi amaclamaktadir. Calisma 2015 yilinda Endonezya Sermaye Piyasasi'nda (Endonezya Menkul Kiymetler Borsasi (IDX)) kayitli olan finans sektoru disindaki sirketler uzerinde yapilmistir. Calismada nicel veriler ve ikincil veri kaynaklari kullanilmistir. Finansal mimarinin etkisinin hipotez testi, Yol Analizi kullanilarak analiz edilmistir ve mulkiyet yapisinin, sermaye yapisinin ve kurumsal yonetimin finansal performans ve kurumsal deger uzerindeki etkisini icermektedir. Calismada olusturulan arastirma modeline uygun bulgular elde edilmistir. Calisma sonucunda Endonezya Baskent Piyasasinda mulkiyet yapisinin, sermaye yapisinin, kurumsal yonetimin ve yonetim kurulunun finansal performans ve kurumsal deger uzerindeki boyutlari ile finansal mimarinin etkisi uzerine teorik bir model ortaya koyulmustur.
Religion, moral attitudes & economic behavior

: Using data for a representative sample of the Dutch population with information about participants’ religious background, we study the association between religion and moral behavior and attitudes. We find that religious people are less accepting of unethical economic behavior (e.g., tax evasion, bribery) and report more volunteering. They are equally likely as non-religious people to betray trust in an experimental game, where social behavior is unobservable and not directed to a self-selected group of recipients. Religious people also report lower preference for redistribution. Considering differences between denominations, Catholics betray less than non-religious people, while Protestants betray more than Catholics and are indistinguishable from the non-religious. We also explore the intergenerational transmission and the potential causality of these associations.