Miracle-dz/UniFAR-FTUs huggingface dataset:
A Comparative Study on Risk Allocation for Different Procurement Type in Malaysian Industry

Risk allocation is one of the important aspects in risk management. However, there is a tendency that risks in construction are being allocated to parties that are least able to resist taking on the risk rather than parties that are more capable to manage the risks. There are different types of procurement that led to different approaches in settling risk allocation between contracting parties. This paper aims to identify risk allocation for different procurement types in construction projects focusing on traditional, design-build and public-private partnership procurement. For this research, a quantitative method was used, where 354 sets of questionnaires were distributed to selected construction firms in Klang Valley. Ninety-two (92) sets of questionnaires were returned and analyzed and the respondents were asked to rate the probability of risk occurrence. The result indicated that the top ranked risk factors are ‘unstable government’, ‘delay in project approvals and permits’, ‘fluctuation of material cost’, ‘poorly written contract’ and ‘inadequate specification in contract’. The recommended risk allocation by respondent for each procurement is presented and found that client and contractor in Traditional procurement, the risks are allocate based on its nature of work. In Design-build, risk factors are mainly allocated to contractor. While in PPP, both contracting parties prefer the majority of the risk factors to be shared. The results of this research will assist practitioners in allocating risks to the party that most qualified to analyze, control, and manage these risks.
Comparison of Electron Capture Rates in the N = 50 Region using 1D Simulations of Core-collapse Supernovae

Recent studies have highlighted the sensitivity of core-collapse supernovae (CCSNe) models to electron-capture (EC) rates on neutron-rich nuclei near the N = 50 closed-shell region. In this work, we perform a large suite of one-dimensional CCSN simulations for 200 stellar progenitors using recently updated EC rates in this region. For comparison, we repeat the simulations using two previous implementations of EC rates: a microphysical library with parametrized N = 50 rates (LMP), and an older independent-particle approximation (IPA). We follow the simulations through shock revival up to several seconds post-bounce, and show that the EC rates produce a consistent imprint on CCSN properties, often surpassing the role of the progenitor itself. Notable impacts include the timescale of core collapse, the electron fraction and mass of the inner core at bounce, the accretion rate through the shock, the success or failure of revival, and the properties of the central compact remnant. We also compare the observable neutrino signal of the neutronization burst in a DUNE-like detector, and find consistent impacts on the counts and mean energies. Overall, the updated rates result in properties that are intermediate between LMP and IPA, and yet slightly more favorable to explosion than both.
MINKOWSKI DECOMPOSITION AND GENERATORS OF THE MOVING CONE FOR TORIC VARIETIES

We prove that for smooth projective toric varieties, the Okounkov body of a T-invariant pseudo-effective divisor with respect to a T-invariant flag decomposes as a finite Minkowski sum of indecomposable polytopes. We prove that these inde- composable polytopes form a finite Minkowski base and that they correspond to the rays in the secondary fan. Moreover, we present an algorithm to find the Minkowski base.
Gravitational lensing of gravitational waves: A statistical perspective

In this paper, we study the strong gravitational lensing of gravitational waves (GWs) from a statistical perspective, with particular focus on the high frequency GWs from stellar binary black hole coalescences. These are most promising targets for ground-based detectors such as Advanced Laser Interferometer Gravitational Wave Observatory (aLIGO) and the proposed Einstein Telescope (ET) and can be safely treated under the geometrical optics limit for GW propagation. We perform a thorough calculation of the lensing rate, by taking account of effects caused by the ellipticity of lensing galaxies, lens environments, and magnification bias. We find that in certain GW source rate scenarios, we should be able to observe strongly lensed GW events once per year ($\sim1~\text{yr}^{-1}$) in the aLIGO survey at its design sensitivity; for the proposed ET survey, the rate could be as high as $\sim80~\text{yr}^{-1}$. These results depend on the estimate of GW source abundance, and hence can be correspondingly modified with an improvement in our understanding of the merger rate of stellar binary black holes. We also compute the fraction of four-image lens systems in each survey, predicting it to be $\sim30$ per cent for the aLIGO survey and $\sim6$ per cent for the ET survey. Finally, we evaluate the possibility of missing some images due to the finite survey duration, by presenting the probability distribution of lensing time delays. We predict that this selection bias will be insignificant in future GW surveys, as most of the lens systems ($\sim90$ per cent) will have time delays less than $\sim1$ month, which will be far shorter than survey durations.
Scars in Dirac fermion systems: the influence of an Aharonov–Bohm flux

Time-reversal (  -) symmetry is fundamental to many physical processes. Typically,  -breaking for microscopic processes requires the presence of magnetic field. However, for 2D massless Dirac billiards,  -symmetry is broken automatically by the mass confinement, leading to chiral quantum scars. In this paper, we investigate the mechanism of  -breaking by analyzing the local current of the scarring eigenstates and their magnetic response to an Aharonov–Bohm flux. Our results unveil the complete understanding of the subtle  -breaking phenomena from both the semiclassical formula of chiral scars and the microscopic current and spin reflection at the boundaries, leading to a controlling scheme to change the chirality of the relativistic quantum scars. Our findings not only have significant implications on the transport behavior and spin textures of the relativistic pseudoparticles, but also add basic knowledge to relativistic quantum chaos.
Preprint typeset in JHEP style-HYPER VERSION From Phase Space to Integrable Representations and Level-Rank Duality

We explicitly find representations for different large N phases of ChernSimons matter theory on S × S. These representations are characterised by Young diagrams. We show that no-gap and lower-gap phase of Chern-Simons-matter theory correspond to integrable representations of SU(N)k affine Lie algebra, where as upper-cap phase corresponds to integrable representations of SU(k−N)k affine Lie algebra. We use phase space description of [1] to obtain these representations and argue how putting a cap on eigenvalue distribution forces corresponding representations to be integrable. We also prove that the Young diagrams corresponding to lower-gap and upper-cap representations are related to each other by transposition under level-rank duality. Finally we draw phase space droplets for these phases and show how information about eigenvalue and Young diagram descriptions can be captured in topologies of these droplets in a unified way. ∗arghya@iiserb.ac. in †parikshitdutta@yahoo.co.in ‡suvankar@iiserb.ac. in ar X iv :1 80 1. 07 90 1v 2 [ he pth ] 2 8 M ay 2 01 8
The most effective but largely ignored target for prostate cancer early detection and intervention

Over the past two decades, the global efforts for the early detection and intervention of prostate cancer seem to have made significant progresses in the basic researches, but the clinic outcomes have been disappointing: (1) prostate cancer is still the most common non-cutaneous cancer in Europe in men, (2) the age-standardized prostate cancer rate has increased in nearly all Asian and African countries, (3) the proportion of advanced cancers at the diagnosis has increased to 8.2% from 3.9% in the USA, (4) the worldwide use of PSA testing and digital rectal examination have failed to reduce the prostate cancer mortality, and (5) there is still no effective preventive method to significantly reduce the development, invasion, and metastasis of prostate cancer… Together, these facts strongly suggest that the global efforts during the past appear to be not in a correlated target with markedly inconsistent basic research and clinic outcomes. The most likely cause for the inconsistence appears due to the fact that basic scientific studies are traditionally conducted on the cell lines and animal models, where it is impossible to completely reflect or replicate the in vivo status. Thus, we would like to propose the human prostate basal cell layer (PBCL) as “the most effective target for the early detection and intervention of prostate cancer”. Our proposal is based on the morphologic, immunohistochemical and molecular evidence from our recent studies of normal and cancerous human prostate tissues with detailed clinic follow-up data. We believe that the human tissue-derived basic research data may provide a more realistic roadmap to guide the clinic practice and to avoid the potential misleading from in vitro and animal studies.
Prognostic Impact of Ectopic Fat Deposition within Psoas Muscle in Stage IV Gastric Cancer Patients Undergoing Systemic Chemotherapy

Aims: In this study, we focused on the fat ratio within psoas muscle (FRPM) and sought to clarify the impact of FRPM on overall survival (OS) in stage IV gastric cancer (GC) patients undergoing systemic chemotherapy (n = 79, median age = 69 years, 59 males). Methods: The median FRPM was 1.67 %. Forty patients with FRPM ≥1.67 % were defined as the FRPM-high group, and the remaining 39 patients was defined as the FRPM-low group. The median PMI in male and female patients was 4.35 cm2/m2 and 2.88 cm2/m2. Thirty male patients with PMI ≥4.35 cm2/m2 and 10 female patients with PMI ≥2.88 cm2/m2 was defined as the PMI-high group, and the remaining 39 patients was defined as the PMI-low group. Results: The 1-, 2- and 3- year cumulative OS rate for all cases was 70.8%, 24.3% and 14.6%. The proportion of ECOG-PS 2 or 3 in patients with FRPM-high and FRPM-low was 17.5% (7/40) and 2.6% (1/39). The 1-, 2- and 3- year cumulative OS rate in patients with FRPM-high and FRPM-low was 67.3%, 14.3% and 7.6% in the FRPM-high group and 74.8%, 40.5% and 32.4% in the FRPM-low group (P = 0.0341). The 1-, 2- and 3- year cumulative OS rate in patients with PMI-high and PMI-low was 86.7%, 40.4% and 30.0% in the PMI-high group and 55.8%, 12.8% and 6.4% in the PMI-low group (P < 0.0001). In the multivariate analysis of factors associated with OS, PMI (P = 0.0047) and FRPM (P = 0.0019) were independent predictors for the OS. Conclusion: Higher FRPM can be associated with decreased physical activity, and not only skeletal muscle mass but also skeletal muscle function can be an essential prognostic factor in stage IV GC patients undergoing systemic chemotherapy.
Data mining for prothrombin time and international normalized ratio reference intervals in children

Reference intervals (RIs) help physicians in differentiating healthy from sick individuals. The prothrombin time (PT) and International normalized ratio (INR) fluctuate in coagulation pathway defects and have interlaboratory variability due to the instrument/reagent used. As direct method is difficult in children, we chose an indirect data mining method for the determining PT/INR RIs. The indirect method overcomes the substantial financial and logistic challenges, and ethical restrictions in children, moreover, allows partitioning in more fine-grained age groups. Prothrombin Time/INR measurements performed in patients aged birth-18 years between January 2013 and December 2020, were retrieved from laboratory management system of the Aga Khan Hospital. Reference intervals were computed using an indirect KOSMIC algorithm. The KOSMIC package function on the assumption that the non-pathologic samples follow a Gaussian distribution (after Box-Cox transformation of the data), following an elaborate statistical process to isolate distribution of physiological samples from mixed dataset. A total of 56,712 and 52,245 values were retrieved for PT and INR respectively. After the exclusion of patients with multiple specimens obtained during the study period, RIs were calculated for 37,356 (PT) and 37,192 (INR) children with stratification into 9 age groups. A comparison of 2.5th and 97.5th percentile results with those of established RIs from SickKids Handbook of Pediatric Thrombosis and Hemostasis demonstrated good agreement in between different age groups. This study supports data mining as an alternate approach for establishing PT/INR RIs, specifically in resource-limited settings. The results obtained are specific to studied population and instrument/reagent used. The study also allows understanding of fluctuations in coagulation pathways with increasing age and hence better clinical decision-making based on PT and INR results.
The Effect of Cognitive-Affective Factors on PTSD and Alcohol Use Symptoms: An Investigation on Rumination, Suppression, and Reappraisal

ABSTRACT Background: Posttraumatic stress disorder (PTSD) and alcohol use disorder (AUD) are mental health conditions that often co-occur. The complexity of this comorbidity is well-documented, though the role of malleable cognitive-affective factors in PTSD/AUD warrants further study. Specifically, attaining a more comprehensive understanding of the role of malleable cognitive-affective factors in individuals with symptoms of PTSD/AUD may have important implications for future research, such as in treatment-seeking individuals. Extant examinations of cognitive-affective factors have demonstrated unique associations of cognitive reappraisal, expressive suppression, and rumination in PTSD symptom severity, though these effects had yet to be explored in subgroups of comorbid PTSD/AUD. Methods: In a sample of trauma-exposed individuals (n = 334) recruited to participate through an internet labor market, we first empirically examined latent subgroups of PTSD/AUD symptoms using latent profile analysis, then included expressive suppression, cognitive reappraisal, and four dimensions in the model to elucidate their role in specific profile patterns of PTSD/AUD symptom typologies. Results: Our results support a four-class model of PTSD/AUD symptoms, with unique predictive effects of expressive suppression, problem-focused thoughts, repetitive thoughts, and anticipatory thoughts on latent profile status. Conclusions: These findings may have important implications for future research focused on examining cognitive-affective patterns as they apply to intervention techniques in treatment-seeking individuals with symptoms of PTSD/AUD.
Health State Utility Values Associated with Cochlear Implants in Adults: A Systematic Review and Network Meta-Analysis

Objectives: The cost-effectiveness of bilateral cochlear implants in adults remains uncertain despite established clinical benefits. In cost-effectiveness studies, benefit is often measured by change in health state utility value (HSUV), a single number summary of health-related quality of life anchored at 0 (state of being dead) and 1 (perfect health). Small differences in bilateral cochlear implant HSUV change conclusions of published models, and invalid estimates can therefore mislead policy and funding decisions. As such, we aimed to review and synthesize published HSUV estimates associated with cochlear implants. Design: We included observational or experimental studies reporting HSUV for adult patients (age ≥18 years) with at least moderate-profound sensorineural hearing loss in both ears who received unilateral or bilateral cochlear implants. We searched MEDLINE, EMBASE, PsycINFO, and Cochrane Library databases up to May 1, 2021. Study and participant characteristics and HSUV outcomes were extracted. Narrative synthesis is reported for all studies. A Bayesian network meta-analysis was conducted to generate pooled estimates for the mean difference in HSUV for three comparisons: (1) unilateral cochlear implant versus preimplant, (2) bilateral cochlear implants versus preimplant, (3) bilateral versus unilateral cochlear implants. Our principal measure was pooled mean difference in HSUV. Results: Thirty-six studies reporting unique patient cohorts were identified. Health Utilities Index, 3 (HUI-3) was the most common HSUV elicitation method. HSUV from 19 preimplant mean estimates (1402 patients), 19 unilateral cochlear implant mean estimates (1701 patients), and 5 bilateral cochlear implants mean estimates (83 patients) were pooled to estimate mean differences in HUI-3 HSUV by network meta-analysis. Compared with preimplant, a unilateral cochlear implant was associated with a mean change in HSUV of +0.17 (95% credible interval [CrI] +0.12 to +0.23) and bilateral cochlear implants were associated with a mean change of +0.25 (95% CrI +0.12 to +0.37). No significant difference in HSUV was detected for bilateral compared with unilateral cochlear implants (+0.08 [95% CrI −0.06 to +0.21]). Overall study quality was moderate. Conclusions: The findings of this review and network meta-analysis comprise the best-available resource for parameterization of cost-utility models of cochlear implantation in adults and highlight the need to critically evaluate the validity of available HSUV instruments for bilateral cochlear implant populations. Protocol registration: PROSPERO (CRD42018091838)
Risk factors associated with adverse pregnancy outcomes and postpartum exacerbation in women with myasthenia gravis

Myasthenia gravis (MG), an autoimmune neuromuscular disease affecting women of childbearing age, exerts an impact on pregnancy, and vice versa. The purposes of the study were to evaluate adverse pregnancy outcomes and postpartum exacerbation in a cohort of Asian MG women, and to explore the predictors for these outcomes.
Oncogenic Addiction of Fibrolamellar Hepatocellular Carcinoma to the Fusion Kinase DNAJB1-PRKACA

Abstract Purpose: Gene fusions are drivers of many pediatric tumors. In fibrolamellar hepatocellular carcinoma (FLC), a fusion of DNAJB1 and PRKACA is the dominant recurrent mutation. Expression of the DNAJB1-PRKACA fusion gene in mice results in a tumor that recapitulates FLC. However, it is not known whether transient expression of DNAJB1-PRKACA is sufficient only to trigger tumor formation or whether ongoing expression is necessary for maintenance and progression. Experimental Design: We screened short hairpin RNAs (shRNA) tiled over the fusion junction and identified several potent and specific candidates in vitro and two independent FLC patient-derived xenografts (PDX). Results: We show that continued DNAJB1-PRKACA expression is not only required for continued tumor growth, but additionally its inhibition results in cell death. Inhibition of DNAJB1-PRKACA by an inducible shRNA in cells of PDX of FLC resulted in cell death in vitro. Induction of the shRNA inhibits FLC tumors growing in mice with no effect on xenografts from a hepatocellular carcinoma cell line engineered to express DNAJB1-PRKACA. Conclusions: Our results validate DNAJB1-PRKACA as the oncogene in FLC and demonstrate both a continued requirement for the oncogene for tumor growth as well as an oncogenic addiction that can be exploited for targeted therapies. We anticipate our approach will be useful for investigations of other fusion genes in pediatric cancers and spur development of precision therapies.
Vigorous physical activity, incident heart disease, and cancer: how little is enough?

Abstract Aims Vigorous physical activity (VPA) is a time-efficient way to achieve recommended physical activity levels. There is a very limited understanding of the minimal and optimal amounts of vigorous physical activity in relation to mortality and disease incidence. Methods and results A prospective study in 71 893 adults [median age (IQR): 62.5 years (55.3, 67.7); 55.9% female] from the UK Biobank cohort with wrist-worn accelerometry. VPA volume (min/week) and frequency of short VPA bouts (≤2 min) were measured. The dose–response associations of VPA volume and frequency with mortality [all-cause, cardiovascular disease (CVD) and cancer], and CVD and cancer incidence were examined after excluding events occurring in the first year. During a mean post-landmark point follow-up of 5.9 years (SD ± 0.8), the adjusted 5-year absolute mortality risk was 4.17% (95% confidence interval: 3.19%, 5.13%) for no VPA, 2.12% (1.81%, 2.44%) for >0 to <10 min, 1.78% (1.53%, 2.03%) for 10 to <30 min, 1.47% (1.21%, 1.73%) for 30 to <60 min, and 1.10% (0.84%, 1.36%) for ≥60 min. The ‘optimal dose’ (nadir of the curve) was 53.6 (50.5, 56.7) min/week [hazard ratio (HR): 0.64 (0.54, 0.77)] relative to the 5th percentile reference (2.2 min/week). There was an inverse linear dose-response association of VPA with CVD mortality. The ‘minimal’ volume dose (50% of the optimal dose) was ∼15 (14.3, 16.3) min/week for all-cause [HR: 0.82 (0.75, 0.89)] and cancer [HR: 0.84 (0.74, 0.95)] mortality, and 19.2 (16.5, 21.9) min/week [HR: 0.60 (0.50, 0.72)] for CVD mortality. These associations were consistent for CVD and cancer incidence. There was an inverse linear association between VPA frequency and CVD mortality. 27 (24, 30) bouts/week was associated with the lowest all-cause mortality [HR: 0.73 (0.62, 0.87)]. Conclusion VPA of 15–20 min/week were associated with a 16–40% lower mortality HR, with further decreases up to 50–57 min/week. These findings suggest reduced health risks may be attainable through relatively modest amounts of VPA accrued in short bouts across the week.
The prognostic role of advanced hemodynamic variables in patients with left ventricular assist devices

Background: Invasive hemodynamic variables obtained from right heart catheterization have been used for risk-stratifying patients with advanced heart failure. However, there is a paucity of data on the prognostic value of invasive hemodynamic variables in patients with left ventricular assist devices (LVAD). We hypothesized that cardiac power output (CPO), cardiac power efficiency (CPE), and left ventricular stroke work index (LVSWI) can serve as prognostic markers in patients with LVADs. Methods: Baseline hemodynamic data from patients who had LVAD ramp studies at our institution from 4/2014 to 7/2018 were prospectively collected, from which advanced hemodynamic variables (CPO, CPE, and LVSWI) were retrospectively analyzed. Univariate and multivariable analyses were performed for hemocompatibility-related adverse events (HRAE), HF admissions, and mortality. Results: Ninety-one participants (age 61 ± 11 years, 34% women, 40% Black or African American, and 38% ischemic cardiomyopathy) were analyzed. Low CPE was significantly associated with mortality (HR 2.42, 95% CI 1.02–5.74, p = 0.045) in univariate analysis and Kaplan–Meier analysis (p = 0.04). Low LVSWI was significantly associated with mortality (HR 2.13, 95% CI 1.09–4.17, p = 0.03) in univariate analysis and Kaplan–Meier analysis (p = 0.02). CPO was not associated with mortality. CPO, CPE, and LVSWI were not associated with HRAE or HF admissions. Conclusions: Advanced hemodynamic variables can serve as prognostic indicators for patients with LVADs. Low CPE and LVSWI are prognostic for higher mortality, but no variables were associated with HF admissions or HRAEs.