Miracle-dz/UniFAR-FTUs huggingface dataset:
Receptor tyrosine kinase targeting in glioblastoma: performance, limitations and future approaches

From all central nervous system tumors, gliomas are the most common. Nowadays, researchers are looking for more efficient treatments for these tumors, as well as ways for early diagnosis. Receptor tyrosine kinases (RTKs) are major targets for oncology and the development of small-molecule RTK inhibitors has been proven successful in cancer treatment. Mutations or aberrant activation of the RTKs and their intracellular signaling pathways are linked to several malignant diseases, including glioblastoma. The progress in the understanding of malignant glioma evolution has led to RTK targeted therapies with high capacity to improve the therapeutic response while reducing toxicity. In this review, we present the most important RTKs (i.e. EGFR, IGFR, PDGFR and VEGFR) currently used for developing cancer therapeutics together with the potential of RTK-related drugs in glioblastoma treatment. Also, we focus on some therapeutic agents that are currently at different stages of research or even in clinical phases and proved to be suitable as re-purposing candidates for glioblastoma treatment.
Improving Phosphorus Use through Co-inoculation of Vesicular Arbuscular Mycorrhizal Fungi and Phosphate-Solubilizing Bacteria in Maize in an Acidic Alfisol

Performance of three vesicular arbuscular mycorrhizal (VAM) fungi cultures and a phosphate-solubilizing bacteria (PSB) culture alone or in combination with or without 75% of the recommended P2O5 dose based on soil-test crop response model was examined in maize in a phosphorus (P)-deficient acidic Alfisol in a glasshouse pot experiment. Sole application of VAM besides co-inoculation with PSB (Pseudomonas striata) and inorganic P stimulated mycorrhizal root colonization. Sole application of PSB, VAMT (Glomus intraradices), and VAMI (Glomus mosseae) as well as co-inoculation of VAM with PSB significantly improved crop productivity besides grain protein content, thus indicating a synergistic interaction between VAM and PSB. Application of VAMT or VAMI + PSB + 75% P2O5 remained at par with sole application of 100% P2O5 dose with regard to productivity, nutrient uptake, and soil fertility status (particularly P), thus indicating economization of fertilizer P to the tune of about 25% without compromising crop productivity and soil fertility in an acidic Alfisol.
A direct comparison of pulsatile and non-pulsatile rough-wall turbulent pipe flow

Pulsatile rough-wall turbulent pipe flow is compared against its non-pulsatile counterpart using data obtained from direct numerical simulation. Results are presented at a mean friction Reynolds number of 540 for a set of three geometrically scaled roughness topographies at a single forcing condition, which, based on existing classifications, falls into the current-dominated very-high-frequency regime. By comparing the pulsatile data against an equivalent non-pulsatile dataset (Chan et al., J. Fluid Mech., vol. 854, 2018, pp. 5–33), the key differences (and similarities) between the forced and unforced configurations are identified. A major finding of this study is that the flow in the outer region retains its self-similar functional form under pulsatile rough-wall conditions, and, as a result, Townsend’s outer-layer similarity hypothesis holds for the roughness-forcing combinations considered here. On the other hand, the unsteady cases exhibit a rich array of flow physics in the region beneath the roughness crests not observed in the steady case. These differences are examined using a Moody chart, which encapsulates how the hydraulic properties of pulsatile rough-wall pipe flow differ from their non-pulsatile counterpart.
Violence against Women and Girls

Violence against women and girls is defined as ‘any act of gender-based violence that results in, or is likely to result in, physical, sexual or psychological harm or suffering to women, including threats of such acts, coercion or arbitrary deprivation of liberty, whether occurring in public or in private life’. In this definition, violence is given its gender-related status and constructed as a problem which facilitates the enduring subjugation of women in society. As well as being a violation of individual rights, violence against women and girls prevents them from flourishing and contributing to their families and communities. It thus has an impact on the economic and social well-being of any society. It also holds back progress on international development targets. Violence against women and girls encompasses rape in conflict, female genital mutilation, stalking and harassment, child sexual abuse, ‘honour’-based violence, forced marriage, and domestic violence. It has physical, sexual, psychological, and economic consequences. This chapter examines the health issues relating to violence against women and girls, the steps taken so far to prevent and cater for health implications, and suggests a way forward.
Base Composition of the DNA of Mycoplasma‐Like Organisms Associated with Various Plant Diseases

DNA was isolated from periwinkle plants infected by various mycoplasma-like organisms (MLOs), and from apple trees affected by apple proliferation. The DNA of the causal agents was separated from the host plant DNA by repeated bisbenzimide-CsCl buoyant density gradient centrifugation which resulted in highly enriched MLO DNA bands characterized by a lower buoyant density than that of the host DNA. The MLO DNAs were hydrolyzed to free bases which were determined by HPLC. The analyses revealed a similar low G + C content as found in the DNAs of several culturable mycoplasmas and spiroplasmas. The values of the DNA of the agents of the diseases investigated were as follows: European aster yellows 23.0, periwinkle virescence 23.5, apple proliferation 23.7, rape virescence 24.2, and phyllody of Diplotaxis erucoidcs 26.2 mol % G + C, respectively. Methylated bases were detected in low amounts only.
Ten Generations of Selection for Lysine Utilization in Japanese Quail

Abstract INTRODUCTION GENETIC differences between breeds or strains of domestic fowl in the ability to grow and/or survive on rations deficient in various vitamins and minerals have been known to exist for some time (Hutt, 1961). Most of these differences were demonstrated as quantitative variations in a single experiment, and it was not until recently that efforts have been made to elucidate differential responses through selection experiments carried out for a period of several generations. In some cases, genetic selection has failed to appreciably alter the requirements of a strain (Hess et al., 1962; Lepore, 1965). In other cases, such as that reported by Lamoreux and Hutt (1948), six generations of selection on two strains of White Leghorns for their response to a riboflavin deficiency resulted in some differences between the strains, but in terms of the amount of riboflavin required, the differences were small. In recent years, there has been .
Evaluation of Preoperative Fine Needle Aspiration Accuracy in Diagnosis of Malignant Parotid Tumors

Objective: To evaluate the diagnostic accuracy of fine needle aspiration (FNA) in detecting malignant parotid tumors. Design: A retrospective study of cases series. Setting: Salmaniya Medical Complex, Otorhinolaryngology Department, Kingdom of Bahrain. Methods: A retrospective study was carried out, between January 2009 and December 2018, for all patients diagnosed with parotid tumors at the Department of Otorhinolaryngology, Head and Neck Surgery at Salmaniya Medical Complex, Manama, Kingdom of Bahrain. Data collection was made from medical records, I-seha and laboratory information system (LIS). 87 patients underwent parotidectomy, of which 30 were excluded due to unsatisfactory diagnoses or missing data. The results of fine needle aspirations were analyzed and compared with the corresponding histopathologic diagnosis. Estimation of sensitivity, specificity, negative predictive value, positive predictive value and accuracy of FNA were calculated. Results: Among the 57 evaluated cases, four cases were further excluded from the final analysis due to unsatisfactory FNA results, therefore only 53 cases remained. The mean age of patients was 48.6 ± 17.2 years. A concordance with histopathology results was observed. 47 cases were diagnosed as benign and five cases were malignant, however, 1 case was diagnosed as malignant by FNA, but not in histopathology. The overall diagnostic accuracy was 98.1% and the prevalence of parotid malignancy was 9.4%. Sensitivity and specificity were 100% and 97.9%, respectively. Positive predictive value was 83.3% while negative predictive value was 100%. Conclusion: Fine needle aspiration is a highly sensitive and specific test in evaluating malignant parotid gland tumors. It is useful and accurate, especially when used hand by hand with the clinical assessment and radiological findings.
The larval hyobranchial apparatus of discoglossoid frogs: its structure and bearing on the systematics of the Anura (Amphibia: Anura)

The morphology of the larval hyobranchial apparatus of discoglossoid frog species representing the genera Ascaphus, Alytes, Bombina, and Discoglossus is described and the resulting characters were analysed cladistically. Seven species representing seven major lineages of frogs were included in the cladistic analysis of characters. Several changes in the terminology of the musculature are introduced, and a new interpretation of the subarcualis-muscle system is presented. The phylogenetic analysis suggest that the hyobranchial apparatus was substantially altered in the lineages leading to and within the Pipanura. This notably involved fusion, reduction and loss of skeletal structures and muscles, and splitting of certain muscles into muscle groups. The result confirm previous hypotheses based on the study of adults: discoglossoid species retain the most numlerous plesiomorphic characters among extant ianurans. The larval hyobranchial apparatus is in many features structrually similar to that of urodeles. Many of their character states were most likely present in the most recent common ancestor of all living forgs. The cladistic analysis of 31 characters of ithe larval hyobranchial apparatus supports major clades: Anura, Bombinanura, Pipanura, and Pelobatoidea + Neobatrachia. The cladiostic analysis and interpretation of larval characters is in part compatible with phylogenetic hypotheses based on characters of adults and rRNA sequences, but is in conflict with the Mesobatrachia and Archaeobatrachia concepts of other authors.
HOW DOES ISLAMIC BANKING SUPPORT ECONOMICS GROWTH?

Some researchers have argued that the financial system has a vital role in economic growth. Islamic banking that has existed widely in many countries is expected to have a positive role in economic growth. This study aims to examine the impact of Islamic bank financing on economic growth in QISMUT countries. To compare with other full Islamic banking systems, Iran and Sudan also included in this study. By using annual panel data (2005-2015), this paper utilizes an approach to multiple mediating analysis models. The findings demonstrate that Islamic banking financing does not significantly impact economic growth directly. However, Islamic banking financing can possibly influence economic growth indirectly through investment and consumption spending. ======================================================================================================== Bagaimanakah Peran Perbankan Syariah dalam Pertumbuhan Ekonomi? Beberapa peneliti berpendapat bahwa system keuangan memiliki peran penting dalam pertumbuhan ekonomi. Perbankan Islam yang telah ada secara luas di banyak negara diduga memiliki peran positif dalam pertumbuhan ekonomi. Penelitian ini bertujuan untuk menguji peengaruh pembiayaan bank Islam pada pertumbuhan ekonomi di negara QISMUT. Iran dan Sudan dimasukkan dalam objek penelitian ini sebagai pembanding penggunaan sistem keuangan Islam. Menggunakan data panel tahun 2005-2015, penelitian ini menggunakan pendekatan analisis media dengan banyak faktor. Hasil penelitian menunjukkan bahwa pembiayaan bank Islam tidak dapat mempengaruhi pertumbuhan ekonomi secara langsung. Akan tetapi, Bank Islam dapat mempengaruhi pertumbuhan ekonomi secara tidak langsung, yaitu melaui investasi dan konsumsi.
Varietal Differences in the Phenolic Content and Superoxide Radical Scavenging Potential of Wines from Different Sources

Thirty-one wine samples differing in their origin of production and vintages were analyzed for total phenolic content, total and free sulfur dioxide contents, and superoxide radical scavenging potentials. The polyphenol content of red wine ranged from 735.9 to 2858 ppm, and that of white wine was in the range 259.4−720.5 ppm. Total sufur dioxide content ranged from 21.9 to 270.7 ppm, and had no correlation to the color of the wine. Superoxide radical scavenging activity values ranged from 39.3 to 215.9 units/mL for the white wine, and those of red varieties were ∼5−10 times higher. No correlation was observed between the free and total sulfur dioxide contents in the different wine samples tested and their superoxide radical scavenging activity values. A direct correlation between the color of the wine (r = 0.7517), its phenolic content (r = 0.9908), and the ability of the wine constituents to scavenge superoxide radical was, however, established by a simple regression analysis. Keywords: Wine; phenolics; .
Evolution of High‐Speed Jets and Plasmoids Downstream of the Quasi‐Perpendicular Bow Shock

Plasma structures with enhanced dynamic pressure, density, or speed are often observed in Earth's magnetosheath. We present a statistical study of these structures, known as jets and fast plasmoids, in the magnetosheath, downstream of both the quasi‐perpendicular and quasi‐parallel bow shocks. Using measurements from the four Magnetospheric Multiscale (MMS) spacecraft and OMNI solar wind data from 2015–2017, we present observations of jets during different upstream conditions and in the wide range of distances from the bow shock. Jets observed downstream of the quasi‐parallel bow shock are seen to propagate deeper and faster into the magnetosheath and on toward the magnetopause. We estimate the shape of the structures by treating the leading edge as a shock surface, and the result is that the jets are elongated in the direction of propagation but also that they expand more quickly in the perpendicular direction as they propagate through the magnetosheath.
Effects of the freshwater aquarium trade on wild fish populations in differentially-fished areas of the Peruvian Amazon

Base-line data were collected to examine the possible effects of the aquarium trade on Amazon fish populations in differentially-fished locations in the Departmento of Loreto, Peru. Fish abundance, species diversity (richness) and biomass were quantified at three locations with differential fishing pressure, including the Rio Nanay (high pressure), Rio Apayacu and Rio Arambassa (medium) and Rio Yanayacu -Pacaya-Samiria National Reserve (low). Seining results indicated that the location with the highest fishing pressure had reduced fish abundance, species diversity and biomass compared to the other locations. A similar trend was seen using minnow traps. There was no significant difference in abundance, diversity and biomass between the medium and low fishing pressure locations. Habitat differences (pH and conductivity) among the three locations accounted for <13% of the observed variation, and thus it seemed possible that some of the decline in the Rio Nanay location could be tentatively attributed to increased fishing pressure. Although effects of pollution and habitat alteration could not be ruled out, this is one of the first studies to provide quantitative data on the effect of the freshwater aquarium trade on wild fish populations. While results suggest success in the protection of fishes for the aquarium trade in Pacaya-Samiria National Reserve, it also may be sustainable to establish limited levels of fishing, as was found in the medium fishing pressure locations, in order to promote economic opportunities and incentives for habitat preservation for indigenous communities. 2006 The Fisheries Society of the British Isles.
Phosphorylation of558T of Moesin Detected by Site-Specific Antibodies in RAW264.7 Macrophages☆

To determine, whether558Thr in the carboxyl-terminal domain of moesin is phosphorylated in cells other than platelets, rabbit phosphorylation state-specific antibodies were made to the chemically phosphorylated synthetic hexapeptide KYKpTLR of the moesin sequence, as well as to the unphosphorylated form. The affinity-purified antibody populations were specific for either the phosphorylated or the unmodified peptide conjugated to BSA. Site-specific phosphorylation of moesin is detected in RAW macrophages by Western blot analysis, and immunofluorescence studies demonstrate that phosphorylated moesin is localized in filopodial protrusions. After pretreatment with the phosphatase inhibitor calyculin A, a similar effect to that seen in platelets is found, namely a substantial increase in moesin phosphorylation at558Thr and redistribution of phospho-moesin together with F-actin into one or more ring-like structures in the cytoplasm, presumably due to binding of phosphorylated moesin to F-actin.
Utility of Meristic and Morphometric Characters for Identification of Capelin (Mallotus villosus) Stocks in Canadian Atlantic Waters

Multivariate discriminant function analyses were performed on 9 morphometric and 11 meristic characters of capelin (Mallotus villosus) samples at Ile aux Coudres in the St. Lawrence estuary; Sept Iles, Natashquan, and Grande Riviere in the Gulf of St. Lawrence; Southeast Shoal on the Grand Banks; and Herring Neck, Notre Dame Bay, Newfoundland. Analyses of meristic characters provided no evidence of discrete stocks. Analyses of morphometric characters provided strong statistical separation between areas. A posteriori classification of groups yielded 93.1% correct classification for males and 73.3% for females. Only snout length, eye diameter, head length, and body depth contributed significantly to the separation obtained. These findings suggest that meristic characters offer little potential for stock identification in Canadian Atlantic waters. Morphometric characters may prove useful, but further study, corroborated with life history and migration data, is required to confirm this. Key words: capelin, Ma.
Effects of Dietary Supplementation of Barodon on Growth Performance, Innate Immunity and Disease Resistance of Juvenile Olive Flounder, Paralichthys olivaceus, Against Streptococcus iniae

This study was conducted to evaluate the effects of dietary supplementation of Barodon, an anionic alkali mineral complex, on growth, feed utilization, humoral innate immunity and disease resistance of olive flounder. A basal experimental diet was used as a control and supplemented with 0.1, 0.2, 0.3, 0.4, or 0.5% Barodon. Triplicate groups of fish (26.4 ± 0.2 g) were fed one of the diets to apparent satiation twice daily for 10 wk. The growth performance was enhanced (P < 0.05) linearly and quadratically in fish fed diets containing Barodon compared with that in fish fed the control. Feed utilization was significantly improved by Barodon supplementation. Serum lysozyme and antiprotease activities were increased quadratically in Barodon fed groups. Also, significantly higher superoxide dismutase activity was found in Barodon-fed fish. Dietary supplementation of 0.1–0.3% Barodon resulted in significant enhancement of fish disease resistance against Streptococcus iniae. The findings in this study indicate that dietary supplementation of Barodon can enhance growth, feed utilization, innate immunity, and disease resistance of olive flounder and that the optimum level seems to be 0.1% in diets.
The ecological role of chemical stimuli for the zooplankton: Predator‐avoidance behavior in Daphnia

Eight different clones (seven species) of Daphnia had behavioral responses to fish and invertebrate predators. The behavioral response was measured in the laboratory as a change in the average population depth, relative to controls, when exposed to a predator. Behavior for each clone was tested with three common predators: Chaoborus, Lepomis, and Notonecta. Each Daphnia clone responded to at least one predator. Some clones responded to all three predators. The responses are both predator and. prey-specific. The stimulus produced by the predator is a water-soluble chemical that persists for up to 7 h in the laboratory. The number of predator species to which a clone responds shows a positive correlation with average body size of the Daphnia. Number of responses per clone is independent of lake size, although there was a tendency (not statistically significant) for the number of responses to decrease with lake size. Behavioral responses may be components of diel vertical migration and horizontal distribution patterns seen in nature.
Selection for Drought Resistance in Common Bean Also Improves Yield in Phosphorus Limited and Favorable Environments

An estimated 60% of common bean (Phaseolus vulgaris L.) production worldwide is at risk of drought. A breeding program was developed at the International Center of Tropical Agriculture (CIAT) to create drought resistant breeding lines with varietal potential in the small red, small black, cream (mulatinho) and cream-striped (carioca) grain classes. Breeding populations were created from triple or double crosses. Field screening under terminal drought was performed at Palmira, Colombia in the dry season in F 2 , F 3:5 , and F 6:8 generations over two cycles of recurrent selection in the small red and small black classes, and one cycle in the mulatinho and carioca classes. Drought resistant lines yielded significantly more than commercial check cultivars under drought in all color classes. Some outyielded the respective checks by 15 to 25% (depending on color class and trial) in one or more of three favorable environments, or in the combined analysis across favorable environments, and were also earlier to mature. Drought resistant lines presented up to 36% greater yield d -1 in favorable environments. Some also expressed superior yields in a phosphorus-limited environment. Thus, selection for drought resistance has improved yield potential and plant efficiency across different environments. It is suggested that selection under drought stress reveals genes that correct inefficiencies inherited from the wild Phaseolus vulgaris, and are key to yield improvement of common bean.