Miracle-dz/UniFAR-FTUs huggingface dataset:
Gender Differences of NLRP1 Inflammasome in Mouse Model of Alzheimer's Disease

Background: There is a significant gender difference in the incidence and symptoms of Alzheimer's disease (AD), but its mechanisms are not completely understood. Recent studies showed that NLRP1 inflammasome was overexpressed in females under some pathological conditions such as nodular melanoma. Whether NLRP1 signals have a gender difference in AD has not been elucidated. This study was designed to investigate gender difference on the expressions of NLRP1 signals including NLRP1, Capase-1 and IL-1β in the brains of APP/PS1+/− mice. Methods: Female and male APP/PS1+/− mice (30-weeks-old) were used in this study. Amyloid-β (Aβ) plaques were stained with Congo red dye and cell apoptosis was detected by TUNEL staining. Expressions of NLRP1, Capase-1 and IL-1β were measured by immunofluorescent staining and Western blotting assay. Results: The numbers of Aβ plaques in cortex and hippocampus and neuronal apoptosis in cortex were 4 and 2-folds in females than males, respectively (P < 0.001). The average size of Aβ plaques in both cortex (females: 3527.11 ± 539.88 μm2 vs. males: 1920.44 ± 638.49 μm2) and hippocampus (females: 1931 ± 308.61 μm2 vs. males: 1038.55 ± 220.40 μm2) were also larger in females than males (P < 0.01). More interestingly, expressions of NLRP1, Caspase-1, and IL-1β were markedly increased in the cortex of females as compared with males. Conclusions: These findings show that NLRP1 signals are higher in brains of female APP/PS1+/− mice than males, which may be related to the gender differences of AD.
Acute Effects of an Afterschool Running and Reading Program on Executive Functioning in Children: An Exploratory Study

Objective: Emerging research within school settings suggests acute forms of physical activity and exercise lead to improvements in executive functioning among children. However, research pertaining to these effects within the afterschool setting remains limited. The primary purpose of this study was to investigate the acute effects of a community-based afterschool running and reading program on executive functioning in 8 to 12-year-old children. Method: Fifty participants were initially recruited to participate in this study. However, due to the COVID-19 pandemic, data collection was terminated prematurely which resulted in a sample size of 15 participants. Participants (N = 10) from School 1 completed two batteries of executive function assessments (i.e., inhibition, switching, and updating) separated by 15-min of running or 15-min of sedentary reading. Whereas, only 5 participants from School 2 completed assessments of executive functioning prior to and following the running portion of the program (due to the early termination of data collection). Results: Overall, executive function scores improved across each assessment following the running condition when compared to the reading condition (School 1). Inhibition scores significantly improved, and these effects were very large (School 1). Across both schools, improvements in executive functioning following the running portion of the program ranged from small-large in effect size. Conclusion: Findings from the present study provide initial evidence for the acute effects of a community-based afterschool running and reading program on executive functioning in children. Future research with larger samples in afterschool settings is recommended to replicate this preliminary work.
Inflammation and Skeletal Muscle Wasting During Cachexia

Cachexia is the involuntary loss of muscle and adipose tissue that strongly affects mortality and treatment efficacy in patients with cancer or chronic inflammatory disease. Currently, no specific treatments or interventions are available for patients developing this disorder. Given the well-documented involvement of pro-inflammatory cytokines in muscle and fat metabolism in physiological responses and in the pathophysiology of chronic inflammatory disease and cancer, considerable interest has revolved around their role in mediating cachexia. This has been supported by association studies that report increased levels of pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6) in some, but not all, cancers and in chronic inflammatory diseases such as chronic obstructive pulmonary disease (COPD) and rheumatoid arthritis (RA). In addition, preclinical studies including animal disease models have provided a substantial body of evidence implicating a causal contribution of systemic inflammation to cachexia. The presence of inflammatory cytokines can affect skeletal muscle through several direct mechanisms, relying on activation of the corresponding receptor expressed by muscle, and resulting in inhibition of muscle protein synthesis (MPS), elevation of catabolic activity through the ubiquitin-proteasomal system (UPS) and autophagy, and impairment of myogenesis. Additionally, systemic inflammatory mediators indirectly contribute to muscle wasting through dysregulation of tissue and organ systems, including GCs via the hypothalamus-pituitary-adrenal (HPA) axis, the digestive system leading to anorexia-cachexia, and alterations in liver and adipocyte behavior, which subsequently impact on muscle. Finally, myokines secreted by skeletal muscle itself in response to inflammation have been implicated as autocrine and endocrine mediators of cachexia, as well as potential modulators of this debilitating condition. While inflammation has been shown to play a pivotal role in cachexia development, further understanding how these cytokines contribute to disease progression is required to reveal biomarkers or diagnostic tools to help identify at risk patients, or enable the design of targeted therapies to prevent or delay the progression of cachexia.
Revealing Prognostic Value of Skeletal-Related Parameters in Metastatic Castration-Resistant Prostate Cancer on Overall Survival: A Systematic Review and Meta-Analysis of Randomized Controlled Trial

Background The skeleton is a preferred site for prostate cancer metastasis, and once metastases occur, the disease becomes incurable. Increasing evidence indicates the prognostic value of skeletal-related parameters, but remains controversial. Objective To perform a systematic review of the existing literature on assessing the prognostic value of alkaline phosphatase (ALP), bone-specific alkaline phosphatase (BSAP), urinary N-telopeptide (uNTx), bone scan index (BSI), and Brief Pain Inventory Short Form (BPI-SF) score in castration-resistant prostate cancer (CRPC) patients with skeleton metastasis. Evidence Acquisition PubMed, Web of Science, Cochrane Library, Medline, OVID, and Embase between 2010 and 2019 were reviewed. Key terms included randomized trials, prostate cancer, alkaline phosphatase, bone-specific alkaline phosphatase, urinary N-telopeptide, bone scan index, and Brief Pain Inventory Short Form. Data were collected, checked, and analyzed from December 2019 to March 2020. Hazard ratios (HRs) and overall survival (OS) were extracted to estimate the relationship between the above parameters and OS in patients with metastatic prostate cancer (mPCa). Evidence Synthesis A total of 1,055 studies were identified via initial screening, including 1,032 from database research and 23 from other sources. After deduplication, 164 records were further excluded according to titles and abstracts. The remaining 36 potential articles were carefully screened. In the end, 15 eligible studies syntheses, which were published between 2010 and 2019, comprised data for a total of 11,378 patients, whose mean age ranged from 66 to 72 years. The sample size ranged from 82 to 1,901 patients. And the median follow-up time ranged from 24 to 55 months. Based on 15 randomized controlled trials published between 2010 and 2019, higher ALP levels (HR = 1.60, 95% CI: 1.38–1.87 P < 0.001), higher BSAP levels (HR = 1.31, 95% CI: 1.11–1.54 P = 0.001), higher uNTx levels (HR = 1.40, 95% CI: 1.29–1.52 P < 0.001), BSI progression (HR = 1.18, 95% CI: 1.08–1.29 P < 0.001), and higher BPI-SF score (HR = 1.47, 95% CI: 1.35–1.61 P < 0.001) had an association with inferior OS. Conclusions Higher levels of ALP/BSAP and uNTx, a higher BPI-SF score, and progression of BSI predict inferior OS in patients with mCRPC. More randomized control trials are needed to investigate the promising value of these parameters.
Browsing Different Instagram Profiles and Associations With Psychological Well-Being

Social networking sites (SNSs) may be transforming young people's social experiences, and browsing SNSs in particular may harm psychological well-being. However, browsing different types of SNS profiles may differentially relate to psychological well-being. In a large and ethnically diverse sample of emerging adults (N = 405), this experimental study examined changes in state affect and self-perceptions after browsing one of three different types of profiles on Instagram: an acquaintance, an influencer, or one's own profile. Moreover, this study investigated how individual characteristics may moderate relations between browsing and well-being, by exploring feedback seeking behaviors and the fear of missing out. Browsing one's own Instagram profile led to positive changes in psychological well-being, whereas browsing the profile of either an acquaintance or an Instagram influencer led to negative changes in psychological well-being. Many observed effects, especially those found for the acquaintance and influencer conditions, were moderated by participants' dispositional levels of the fear of missing out and feedback seeking, in which effects were primarily observed for those higher in these characteristics. Findings suggest that SNSs may have positive or negative effects on well-being depending on who is online and what those individuals are browsing.
A Mission Concept to Determine the Magnetospheric Causes of Aurora

Insufficiently accurate magnetic-field-line mapping between the aurora and the equatorial magnetosphere prevents us from determining the cause of many types of aurora. An important example is the longstanding question of how the magnetosphere drives low-latitude (growth-phase) auroral arcs: a large number of diverse generator mechanisms have been hypothesized but equatorial magnetospheric measurements cannot be unambiguously connected to arcs in the ionosphere, preventing the community from identifying the correct generator mechanisms. Here a mission concept is described to solve the magnetic-connection problem. From an equatorial instrumented spacecraft, a powerful energetic-electron beam is fired into the atmospheric loss cone resulting in an optical beam spot in the upper atmosphere that can be optically imaged from the ground, putting the magnetic connection of the equatorial spacecraft’s measurements into the context of the aurora. Multiple technical challenges that must be overcome for this mission concept are discussed: these include spacecraft charging, beam dynamics, beam stability, detection of the beam spot in the presence of aurora, and the safety of nearby spacecraft.
New Species Assemblages Disrupt Obligatory Mutualisms Between Figs and Their Pollinators

The reliance of each fig species on its specific pollinator wasp, and vice versa, is the archetype of both obligatory mutualism and coevolution. Pollinator sharing between host fig species is only known to occur among closely related sympatric species. On the Hawaiian island of Kauai, we gathered syconia from 23 non-native fig species, three of which contained the wasp Pleistodontes imperialis. Of the three fig species, one is the wasp’s natural host, Ficus rubiginosa, and another is its sister species, Ficus watkinsiana, which overlaps in native ranges, although researchers have not previously documented pollinator sharing. The third fig species, Ficus rubra, is distant to the others both in terms of phylogenetic relationship and native range. We found viable seeds for all three fig species, whereas species without wasps did not produce seeds. To investigate similarity between these pollinator-sharing fig species, we collected morphometric data for syconia of our study fig species. We found that fig species with and without P. imperialis significantly differ based on the orientation of their inner ostiolar bracts. These findings suggest that pollinator sharing among these three fig species may normally be impeded by pollinator competition in the case of F. watkinsiana, and by geographic distance in the case of F. rubra. This work therefore demonstrates that coevolution depends on interactions within native species assemblages, and that mutualisms can be disrupted in new non-native communities.
COVID-19: Technology, Social Connections, Loneliness, and Leisure Activities: An International Study Protocol

Drawn from the stress process model, the pandemic has imposed substantial stress to individual economic and mental well-being and has brought unprecedented disruptions to social life. In light of social distancing measures, and in particular physical distancing because of lockdown policies, the use of digital technologies has been regarded as the alternative to maintain economic and social activities. This paper aims to describe the design and implementation of an online survey created as an urgent, international response to the COVID-19 pandemic. The online survey described here responds to the need of understanding the effects of the pandemic on social interactions/relations and to provide findings on the extent to which digital technology is being utilized by citizens across different communities and countries around the world. It also aims to analyze the association of use of digital technologies with psychological well-being and levels of loneliness. The data will be based on the ongoing survey (comprised of several existing and validated instruments on digital use, psychological well-being and loneliness), open for 3 months after roll out (ends September) across 11 countries (Austria, France, Germany, India, Malta, Portugal, Romania, Spain, Turkey, and UK). Participants include residents aged 18 years and older in the countries and snowball sampling is employed via social media platforms. We anticipate that the findings of the survey will provide useful and much needed information on the prevalence of use and intensities of digital technologies among different age groups, gender, socioeconomic groups in a comparative perspective. Moreover, we expect that the future analysis of the data collected will show that different types of digital technologies and intensities of use are associated with psychological well-being and loneliness. To conclude, these findings from the study are expected to bring in our understanding the role of digital technologies in affecting individual social and emotional connections during a crisis.
Temporal Dynamics of Rhizobacteria Found in Pequin Pepper, Soybean, and Orange Trees Growing in a Semi-arid Ecosystem

Harsh environmental conditions in drylands force plants and their associated microbial communities to adapt to abiotic stresses. In semi-arid environments, climatic conditions and poor agricultural management have a strong impact on plant yield and thus, enhancing soil fertility by means of beneficial microorganisms such as plant growth-promoting rhizobacteria (PGPR) has been proposed as part of sustainable agricultural management. As drylands will increase due to climate change, studying microbial community dynamics of crops under such conditions is crucial as it might favor rhizobacteria adapted to drought. While the microbiome of many native dryland crops has been characterized, the microbial community composition from non-native crops under semi-arid environmental conditions is understudied. Thus, the aim of this study was to characterize the bacterial community associated with the roots of three crops with different growth cycles, cultivated in the same semi-arid environment, to understand their microbial community composition during the season with the highest temperature in northeast Mexico. We performed high throughput sequencing of the V3-V4 region of the 16S rRNA gene from root samples of Pequin pepper, soybean and orange trees. Classified taxa were evaluated according to crop, sampling time and climatological parameters. Our findings revealed that changes in temporal dynamics of microbial communities correlate with environmental temperature. Moreover, the microbial community of pepper was more diverse and differed from that of soybean and orange. Regarding PGPR, 47.6% of the genera were shared among crops with a high relative abundance of Bacillus, but we also detected crop-specific microbial associations where Serratia was specific to orange trees and Rhodobacter to pepper. When analyzing PGPR in correlation to climatological parameters, Bacillus was found to thrive under lower precipitation rates, higher temperatures and higher evaporation rates in pepper and orange. In contrast, some PGPR commonly used in commercial biofertilizers such as Rhizobium and Azospirillum were affected by high temperatures. This study provides a better understanding of the rhizobacterial assemblies of economically relevant crops grown under a semi-arid environment.
Glutamate Systems in DSM-5 Anxiety Disorders: Their Role and a Review of Glutamate and GABA Psychopharmacology

Serotonin reuptake inhibitors and benzodiazepines are evidence-based pharmacological treatments for Anxiety Disorders targeting serotonin and GABAergic systems, respectively. Although clearly effective, these medications fail to improve anxiety symptoms in a significant proportion of patients. New insights into the glutamate system have directed attention toward drugs that modulate glutamate as potential alternative treatments for anxiety disorders. Here we summarize the current understanding of the potential role of glutamate neurotransmission in anxiety disorders and highlight specific glutamate receptors that are potential targets for novel anxiety disorder treatments. We also review clinical trials of medications targeting the glutamate system in DSM-5 anxiety disorders. Understanding the role of the glutamate system in the pathophysiology of anxiety disorder may aid in developing novel pharmacological agents that are effective in treating anxiety disorders.
Abnormal Connectivity and Brain Structure in Patients With Visual Snow

Objective Visual snow (VS) is a distressing, life-impacting condition with persistent visual phenomena. VS patients show cerebral hypermetabolism within the visual cortex, resulting in altered neuronal excitability. We hypothesized to see disease-dependent alterations in functional connectivity and gray matter volume (GMV) in regions associated with visual perception. Methods Nineteen patients with VS and 16 sex- and age-matched controls were recruited. Functional magnetic resonance imaging (fMRI) was applied to examine resting-state functional connectivity (rsFC). Volume changes were assessed by means of voxel-based morphometry (VBM). Finally, we assessed associations between MRI indices and clinical parameters. Results Patients with VS showed hyperconnectivity between extrastriate visual and inferior temporal brain regions and also between prefrontal and parietal (angular cortex) brain regions (p < 0.05, corrected for age and migraine occurrence). In addition, patients showed increased GMV in the right lingual gyrus (p < 0.05 corrected). Symptom duration positively correlated with GMV in both lingual gyri (p < 0.01 corrected). Conclusion This study found VS to be associated with both functional and structural changes in the early and higher visual cortex, as well as the temporal cortex. These brain regions are involved in visual processing, memory, spatial attention, and cognitive control. We conclude that VS is not just confined to the visual system and that both functional and structural changes arise in VS patients, be it as an epiphenomenon or a direct contributor to the pathomechanism of VS. These in vivo neuroimaging biomarkers may hold potential as objective outcome measures of this so far purely subjective condition.
How Do University Students’ Web Search Behavior, Website Characteristics, and the Interaction of Both Influence Students’ Critical Online Reasoning?

The Internet has become one of the main sources of information for university students’ learning. Since anyone can disseminate content online, however, the Internet is full of irrelevant, biased, or even false information. Thus, students’ ability to use online information in a critical-reflective manner is of crucial importance. In our study, we used a framework for the assessment of students’ critical online reasoning (COR) to measure university students’ ability to critically use information from online sources and to reason on contentious issues based on online information. In addition to analyzing students’ COR by evaluating their open-ended short answers, we also investigated the students’ web search behavior and the quality of the websites they visited and used during this assessment. We analyzed both the number and type of websites as well as the quality of the information these websites provide. Finally, we investigated to what extent students’ web search behavior as well as the quality of the used website contents are related to higher task performance. To investigate this question, we used five computer-based performance tasks and asked 160 students from two German universities to perform a time-restricted open web search to respond to the open-ended questions presented in the tasks. The written responses were evaluated by two independent human raters. To analyze the students’ browsing history, we developed a coding manual and conducted a quantitative content analysis for a subsample of 50 students. The number of visited webpages per participant per task ranged from 1 to 9. Concerning the type of website, the participants relied especially on established news sites and Wikipedia. For instance, we found that the number of visited websites and the critical discussion of sources provided on the websites correlated positively with students’ scores. The identified relationships between students’ web search behavior, their performance in the CORA tasks, and the qualitative website characteristics are presented and critically discussed in terms of limitations of this study and implications for further research.
Centralized IT Decision Making and Cybersecurity Breaches: Evidence from U.S. Higher Education Institutions

ABSTRACT Despite the consensus that information security should become an important consideration in information technology (IT) governance rather than the sole responsibility of the IT department, important IT governance decisions are often made on the basis of fulfilling business needs with a minimal amount of attention paid to their implications for information security. We study how an important IT governance mechanism—the degree of centralized decision making—affects the likelihood of cybersecurity breaches. Examining a sample of 504 U.S. higher-education institutions over a four-year period, we find that a university with centralized IT governance is associated with fewer breaches. Interestingly, the effect of centralized IT governance is contingent on the heterogeneity of a university’s computing environment: Universities with more heterogeneous IT infrastructure benefit more from centralized IT decision making. In addition, we find the relationship between centralized governance and cybersecurity breaches is most pronounced in public universities and those with more intensive research activities. Collectively, these findings highlight the tradeoff between granting autonomy and flexibility in the use of information systems and enforcing standardized, organization-wide security protocols.