Miracle-dz/UniFAR-FTUs huggingface dataset:
Stop self-injuring, then what? Psychosocial risk associated with initiation and cessation of nonsuicidal self-injury from adolescence to early adulthood.

Nonsuicidal self-injury (NSSI) typically begins in adolescence and remits by early adulthood, but few prospective studies have investigated the long-term impact of NSSI initiation and cessation on young people's wellbeing. We examined changes in psychosocial risk associated with NSSI onset and offset in an accelerated longitudinal study of 662 adolescents (12-18 years old) who were followed biennially for 10 years. Of the 133 participants who reported NSSI, 100 had stopped engaging in NSSI by the study's end. NSSI initiation was associated with concurrent increases in depression, anxiety, externalizing symptoms, peer victimization, alcohol, tobacco and illicit substance use, and concurrent declines in physical self-concept, parent, and peer support. As NSSI persisted, youth experienced further increases in anxiety and cannabis use, and declines in physical self-concept. NSSI cessation was associated with concurrent increases in alcohol, cannabis, and tobacco use. With sustained cessation, however, youth experienced gradual improvements in depression, anxiety, externalizing symptoms, peer victimization, as well as gradual reductions in alcohol and tobacco use. By early adulthood, participants who reported ongoing NSSI worked fewer hours and were more likely to delay medical treatment for financial reasons versus those without NSSI histories, and reported less environmental mastery versus those who had discontinued NSSI. Youth who had discontinued NSSI, in turn, reported less environmental mastery and self-acceptance versus youth who never engaged in NSSI. These results contextualize NSSI cessation alongside indicators of psychological, social, and behavioral wellbeing, and underscore the persistence of psychosocial vulnerability after NSSI has resolved. (PsycInfo Database Record (c) 2021 APA, all rights reserved).
Genome-wide association study of gastric cancer- and duodenal ulcer-derived Helicobacter pylori strains reveals discriminatory genetic variations and novel oncoprotein candidates

Genome-wide association studies (GWASs) can reveal genetic variations associated with a phenotype in the absence of any hypothesis of candidate genes. The problem of false-positive sites linked with the responsible site might be bypassed in bacteria with a high homologous recombination rate, such as Helicobacter pylori , which causes gastric cancer. We conducted a small-sample GWAS (125 gastric cancer cases and 115 controls) followed by prediction of gastric cancer and control (duodenal ulcer) H. pylori strains. We identified 11 single nucleotide polymorphisms (eight amino acid changes) and three DNA motifs that, combined, allowed effective disease discrimination. They were often informative of the underlying molecular mechanisms, such as electric charge alteration at the ligand-binding pocket, alteration in subunit interaction, and mode-switching of DNA methylation. We also identified three novel virulence factors/oncoprotein candidates. These results provide both defined targets for further informatic and experimental analyses to gain insights into gastric cancer pathogenesis and a basis for identifying a set of biomarkers for distinguishing these H. pylori -related diseases.
Long-term outcomes of angioplasty for pediatric renovascular hypertension: A single-center experience

Objectives We used single-center data to evaluate the long-term outcome of percutaneous transluminal angioplasty (PTA) for pediatric renovascular hypertension (RVH) and to analyze the factors that influence effectiveness. Methods We retrospectively evaluated 33 pediatric RVH patients (18 boys; mean age: 9.1 ± 4 years, range: 2–16) who underwent PTA from January 2007 to December 2019. 15 patients had Takayasu arteritis (TA) and 18 were non-TA. The median follow-up from the initial PTA was 69 months (range: 12–157; IQR: 25.5–89). Results The technical success rate of 52 PTA procedures was 90.4% in 33 children. Renal artery stents were implanted in two patients, external guidewires were used in two patients, and a drug-coated balloon was used in only one patient. The overall effective rate of PTA was 63.6%, including cured 39.4% and improved 24.2%, at the end of follow-up. Overall clinical outcomes were not statistically different between the TA and non-TA groups (p = 0.316), nor were cure rates (p = 0.072). 15 patients received reintervention due to restenosis after the first successful PTA; the interval was 2–56 months (median: 12 months). Four patients received reintervention due to a failed PTA. A total of four patients received open surgery. Binary logistics regression analysis showed that stenosis length and residual stenosis rate were strongly correlated with effective PTA (p = 0.045, p = 0.044). Conclusions As a primary treatment for pediatric RVH, PTA can achieve satisfactory results, which are influenced by lesion length and residual stenosis rate.
The Agency of Making and Architecture Education: Design-Build Curriculum in a New School of Architecture

Developing a curriculum for Canada’s newest school of architecture in forty years created the opportunity for a commitment to new pedagogy that would address changes and needs in the profession, particularly in the Northern context. The tri-cultural mandate of the school (First Nations, Francophone, Anglophone), and the desire to create a complete design-build curriculum aligned with the community’s commitment for change and the location of the school in former historic buildings downtown. The design-build curriculum means that in each studio year the cohort will design and construct at full scale a project relevant to the context of the school such as the ice fishing huts completed this past year. Optional design/build workshops in the summer in Europe allowed for additional experimentation of construction methods in other specific northern contexts. This paper outlines the larger and specific contexts for the design of the design-build curriculum, the processes of the first year of implementation, the agency of making both for the student and instructors and concludes with a discussion of the trajectory of design-build in the school.
Assessment of molecular response to tyrosine kinase inhibitors in Tunisian Patients with Chronic Myeloid Leukemia

Aim This study was carried out to assess the minimal residual disease in Tunisian patients with chronic myeloid leukemia (CML) treated with tyrosine kinase inhibitors in routine clinical practice, to recognize potentially eligible carrier for treatment discontinuation, based on a molecular response (MR). Patients and Methods A retrospective study was carried out in the Hospital University of Sfax, south of Tunisia from January 2016 to October 2020, including all CML patients in the chronic phase at diagnosis, treated with TKI (tyrosine kinase inhibitors) for a minimum duration of 6 months. Quantitative assessment of the BCR-ABL transcript was performed using the Cepheid Xpert BCR-ABL ultra-assay. Molecular response and outcome were evaluated, according to the European Leukemia Net guidelines. Results A total of 162 CML patients were carried out. The median age was 50 years, the sex ratio M/F was 1.62. The rate of cumulative EMR; MMR and DMR was 80.8%; 73.8% and 55.9% respectively. According to the ELN criteria, 141 CML patients were evaluable. Optimal, suboptimal response and failure were noted in 81 (57.4%), 33(23.4%), and 27(19.1%) patients, respectively. Overall survival (OS) and progression-free survival (PFS) were 96.3% and 85%. Risk factors for an event (death/progression) were lack of EMR, MMR, and DMR (P < 0.05). Among 149 patients with sustained DMR; 14 (8.6%) CML patients have discontinued TKI therapy. Conclusion Despite the limit of our study (duration and size), the available real-life molecular responses with TKI therapy should be considered to identify potentially CML patients eligible for discontinuation of TKI therapy.
Using a monolingual screening test for assessing bilingual children

ABSTRACT Bilingual language development is different from monolingual language development. The lack of appropriate assessment tools geared to the bilingual population has led to inaccurate over-diagnosis of bilingual children with typical language development (TLD) as children with Developmental Language Disorder (DLD) and under-diagnosis of bilingual children with DLD. The present paper addresses this challenge by focusing on Hebrew as a second language (L2) of bilingual preschool children whose first language (L1) is either English or Russian, taking into consideration both chronological age (CA) and age of onset of bilingualism (AOB). This study aimed to generate bilingual standards for a monolingual screening test, Goralnik Screening Test for Hebrewby arriving at appropriate bilingual typical development cut-off points. A total of 443 bilingual Hebrew speaking children (397 with TLD and 46 with DLD), ages 61–78 months (M = 70; SD = 4), 199 with L1 English and 244 with L1 Russian, took part in the study. The results demonstrate low diagnostic accuracy when a monolingual test with monolingual norms is used for bilingual children, in contrast with increased diagnostic accuracy when bilingual standards are used for bilingual children. The paper concludes by showing the importance of bilingual standards when assessing clinical populations with varying ages of acquisition, and in particular, for those who were exposed to their second language after the age of four.
Single-centre experience with endovascular rotational thrombectomy for single session salvage of thrombosed arteriovenous fistulas and grafts

Objectives: This paper documents our experience and outcomes of using a relatively new endovascular rotational thrombectomy device for salvage of thrombosed vascular access. Methodology: A retrospective study reviewing patients with thrombosed native AVF or AVG who underwent endovascular declotting using a rotational thrombectomy device between November 2018 and May 2020 at a tertiary university hospital in Southeast Asia. We evaluated demographics, procedural data, technical and procedural success, patency rates and complications. Results: A total of 40 patients underwent single session endovascular declotting of thrombosed vascular access. The mean follow-up period was 21.6 months (range 13.4–31 months). The technical success was 92.5% and clinical success was 80%. About 50% of patients had concomitant thrombolysis for pharmacomechanical thrombectomy. One patient had a myocardial infarction during the post-operative period. There were no other major complications within 30 days. The primary patency was 45.5% at 6 months and 22.7% at 12 months. Assisted primary patency was 68.1% at 6 months and 61.6% at 12 months, which was maintained up to 2 years. The secondary patency was 84.1% at 6 and 12 months. Conclusion: Our study shows that rotational thrombectomy device for single session thrombectomy of thrombosed arteriovenous fistulas and grafts is safe and effective. A high technical and clinical success rate was achieved, with low complication rates and specific advantages compared to other techniques, including reduced length of hospital stay. Our reported mid-term outcomes are reasonable with an assisted primary patency of 62% at 12 and 24 months. The use of newer techniques and novel dedicated thrombectomy devices show promise.
Variant profiling of colorectal adenomas from three patients of two families with MSH3-related adenomatous polyposis

The spectrum of somatic genetic variation in colorectal adenomas caused by biallelic pathogenic germline variants in the MSH3 gene, was comprehensively analysed to characterise mutational signatures and identify potential driver genes and pathways of MSH3-related tumourigenesis. Three patients from two families with MSH3-associated polyposis were included. Whole exome sequencing of nine adenomas and matched normal tissue was performed. The amount of somatic variants in the MSH3-deficient adenomas and the pattern of single nucleotide variants (SNVs) was similar to sporadic adenomas, whereas the fraction of small insertions/deletions (indels) (21–42% of all small variants) was significantly higher. Interestingly, pathogenic somatic APC variants were found in all but one adenoma. The vast majority (12/13) of these were di-, tetra-, or penta-base pair (bp) deletions. The fraction of APC indels was significantly higher than that reported in patients with familial adenomatous polyposis (FAP) (p < 0.01) or in sporadic adenomas (p < 0.0001). In MSH3-deficient adenomas, the occurrence of APC indels in a repetitive sequence context was significantly higher than in FAP patients (p < 0.01). In addition, the MSH3-deficient adenomas harboured one to five (recurrent) somatic variants in 13 established or candidate driver genes for early colorectal carcinogenesis, including ACVR2A and ARID genes. Our data suggest that MSH3-related colorectal carcinogenesis seems to follow the classical APC-driven pathway. In line with the specific function of MSH3 in the mismatch repair (MMR) system, we identified a characteristic APC mutational pattern in MSH3-deficient adenomas, and confirmed further driver genes for colorectal tumourigenesis.
Adaptive control of nonlinear smart base‐isolated buildings using Gaussian kernel functions

In this paper, a direct adaptive control scheme using Gaussian kernel functions is presented for the active control of nonlinear base‐isolated buildings. The control scheme is based on direct adaptive control where the system response is made to follow a desired trajectory. The number of kernel functions is adaptively estimated using a growing and pruning strategy which results in the reduction of the computational overhead. Stable adaptive parameter update laws for Gaussian kernels are derived using Lyapunov approach. Performance of the proposed control scheme is evaluated on the recently developed nonlinear three‐dimensional base‐isolated benchmark structure. The analytical model of the benchmark structure is highly complex due its three‐dimensional nature incorporating lateral and torsional responses, the biaxial interaction of the nonlinear bearings at the isolation layer, and strong coupling between the isolation level forces and the superstructure responses. Control action is provided by eight actuators distributed at the isolation level in each principal direction of the structure, and utilizing the state information corresponding to the base of the structure only. Results are presented using a comprehensive set of the performance indices to realistically quantify the trade‐offs associated with the control of nonlinear base‐isolated buildings. The main advantages of the adaptive controller presented in this paper are: (i) the control algorithm does not require estimating the system parameters, specifically, mass, stiffness and damping, (ii) the exact nature of the nonlinear dynamics need not be known, and (iii) the control synthesis is noniterative, and on‐line. Copyright © 2007 John Wiley & Sons, Ltd.
Lateral-extra articular tenodesis vs. anterolateral ligament reconstruction in skeletally immature patients undergoing anterior cruciate ligament reconstruction

Purpose of review The aim of this study was to review the most recent available evidence about lateral-extra articular tenodesis (LET) and anterolateral ligament (ALL) reconstruction in young patients treated for anterior cruciate ligament (ACL) injury. Recent findings The ALL of the knee acts as a secondary stabilizer of the knee preventing anterior translation and internal rotation. In vitro and in vivo biomechanical studies as well as prospective clinical trials have shown the importance of the ALL in knee biomechanics. The ALL injury has a synergetic impact on the knee stability in patients with acute ACL injury. ALL augmentation of ACL provides reduction of knee instability and graft failure and higher return to sport rates in high-risk patients. It has not been demonstrated that extra-articular procedures increase the risk of knee osteoarthritis secondary to knee over-constriction. Both Iliotibial band (ITB) ALL reconstruction and modified Lemaire LET have been shown safe and effective. Minimal biomechanical or clinical differences have been found between the two reconstruction methods. Summary Young patients with ACL tears and risk factors such as laxity or pivot shift willing to return to sports may benefit from ALL augmentation. Therefore, it is essential to identify these high-risk patients to individualize treatment.
Performance of Bonded Bridge Deck Overlays in Alabama

Bridge deck rehabilitation via overlaying has been widely used in colder regions of the U.S., but not in Alabama due to a warmer climate and nonuse of deicing salts on bridge decks. However, Alabama does have some experience with bonded deck overlays, and the purpose of this work is to document the performance of the overlays that were placed in Alabama prior to the Summer of 2000. The service life performance of the Alabama Department of Transportation's 19 bonded bridge deck overlays to date are as follows: 1) thin (6.4 mm or 1/4 in.) urethane polymer concrete (4 overlays) provided a service life of 3 years and left much to be desired before the 3 years; 2) thin (9.5 mm or 3/8 in.) polyester polymer concrete (12 overlays) has provided highly variable performance (4 of the overlays had service lives of less than 1 year, and the remaining 7 overlays are approximately 10 years old and continue in service; however, most are near the end of their service life); 3) thin (9.5 mm or 3/8 in.) epoxy co-polymer concrete (Flexogrid-2 overlays) has given excellent performance (both overlays are 8 years old, located on I-20 bridges, and remain in excellent condition); and 4) thin (12.7-19.1 mm or 1/2-3/4 in.) asphaltic based NOVACHIP (1 overlay) has been in service for 3 years (during this short period, it has and continues to perform in an excellent manner).
The clinical and functional outcomes of a large naturalistic cohort of young people accessing national early psychosis services

Aims: Services for individuals with a first episode of psychosis or at ultra-high risk of psychosis have become a treatment model of choice in mental health care. The longitudinal changes in clinical and functional outcomes as a result of real-world treatment remain under-reported. Methods: We analysed data from first episode of psychosis and ultra-high risk services delivered across Australian primary youth mental health care services known as headspace between 19 June 2017 and 30 September 2019. Outcome measures were completed and entered into a minimum dataset every 90 days a participant was receiving treatment and included psychiatric symptomatology (Brief Psychiatric Rating Scale and psychological distress, K10) and psychosocial functioning (Social and Occupational Functioning Assessment Scale and My Life Tracker). Linear mixed-effects models were used to evaluate changes in outcome over time. Results: Outcome data from a total of 1252 young people were evaluated (643 first episode of psychosis, 609 ultra-high risk). Of those who entered ultra-high risk services, 11.8% transitioned to first episode of psychosis services. Overall, substantial improvement in clinical (Brief Psychiatric Rating Scale, K10) and functional (Social and Occupational Functioning Assessment Scale, My Life Tracker) outcomes were seen across groups and outcomes. Ultra-high risk patients showed a greater reduction in distress symptoms, while first episode of psychosis patients experienced a greater reduction in positive psychosis symptoms. Although clinical outcomes showed a plateau effect after approximately 3 months of care, improvement in functional outcomes (Social and Occupational Functioning Assessment Scale, My Life Tracker) continued later in treatment. Conclusion: These findings support the use of real-time, real-world and low-cost administrative data to rigorously evaluate symptomatic and functional outcomes in early psychosis treatment settings. Findings that functional outcomes improve past the remittance of clinical outcomes also support the functional recovery focus of early psychosis services and remaining high levels of distress suggest the need for ultra-high risk services to extend beyond 6 months of care.
Examining the validity of the drivers of COVID-19 vaccination acceptance scale using Rasch analysis

ABSTRACT Background To well control the pandemic of COVID-19, herd immunity should be achieved. However, people, especially those with better physical conditions (e.g., young adults), may not accept COVID-19 vaccines. Understanding university students’ willingness or reluctance to uptake COVID-19 vaccination is important. Aim This study aimed to examine the psychometric properties of the DrVac-COVID19S, an instrument that helps assess motivations/drivers of COVID-19 vaccination uptake among university students. Research Design and Methods Using convenience sampling and cross-sectional design, university students (930 from Taiwan [38.0% males] and 1,244 from Ghana [63.3% males]) completed the DrVac-COVID19S using an online survey (Taiwanese students) or paper-and-pen method (Ghanaian students). Rasch analysis was used to examine the psychometric properties of the DrVac-COVID19S. Results All 12 items in the DrVac-COVID19S had a satisfactory fit in the Rasch models (infit MnSq = 0.74 to 1.49; outfit MnSq = 0.72 to 1.42). Moreover, the seven-point Likert scale used in the DrVac-COVID19S demonstrated monotonically increasing in their difficulties, which indicated the ordered category. Additionally, no differential item functioning was displayed in the DrVacCOVID-19S across Taiwanese and Ghanaian students. Conclusions The DrVacCOVID-19S has good psychometric features to help healthcare providers assess individuals’ (especially university students) motivations or drivers to get the COVID-19 vaccination.
Splicing predictions, minigene analyses, and ACMG‐AMP clinical classification of 42 germline PALB2 splice‐site variants

PALB2 loss‐of‐function variants confer high risk of developing breast cancer. Here we present a systematic functional analysis of PALB2 splice‐site variants detected in approximately 113,000 women in the large‐scale sequencing project Breast Cancer After Diagnostic Gene Sequencing (BRIDGES; https://bridges-research.eu/). Eighty‐two PALB2 variants at the intron‐exon boundaries were analyzed with MaxEntScan. Forty‐two variants were selected for the subsequent splicing functional assays. For this purpose, three splicing reporter minigenes comprising exons 1–12 were constructed. The 42 potential spliceogenic variants were introduced into the minigenes by site‐directed mutagenesis and assayed in MCF‐7/MDA‐MB‐231 cells. Splicing anomalies were observed in 35 variants, 23 of which showed no traces or minimal amounts of the expected full‐length transcripts of each minigene. More than 30 different variant‐induced transcripts were characterized, 23 of which were predicted to truncate the PALB2 protein. The pathogenicity of all variants was interpreted according to an in‐house adaptation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology (ACMG‐AMP) variant classification scheme. Up to 23 variants were classified as pathogenic/likely pathogenic. Remarkably, three ±1,2 variants (c.49‐2A>T, c.108+2T>C, and c.211+1G>A) were classified as variants of unknown significance, as they produced significant amounts of either in‐frame transcripts of unknown impact on the PALB2 protein function or the minigene full‐length transcripts. In conclusion, we have significantly contributed to the ongoing effort of identifying spliceogenic variants in the clinically relevant PALB2 cancer susceptibility gene. Moreover, we suggest some approaches to classify the findings in accordance with the ACMG‐AMP rationale. © 2021 The Authors. The Journal of Pathology published by John Wiley & Sons, Ltd on behalf of The Pathological Society of Great Britain and Ireland.