Miracle-dz/UniFAR-FTUs huggingface dataset:
Production performance, egg quality, and uterine gene expression for layers as affected by N-Carbamylglutamate supplementation

Introduction Supplementation of exogenous additives is a strategy to improve laying performance of layers by regulating uterine function. N-Carbamylglutamate (NCG) as an activator for endogenous arginine synthesis has the potential to regulate the laying performance of layers, but its effects have not been fully understood. Methods This study investigated the effects of dietary supplementation of NCG on production performance, egg quality, and uterine gene expression in layers. A total of 360 45-week-old layers with a genetic line of Jinghong No. 1 were used in this study. The experimental period was 14 weeks. All birds were divided into 4 treatments with 6 replicates per treatment and 15 birds per replicate. Dietary treatments were based on a basal diet and supplemented with 0, 0.08, 0.12, or 0.16% NCG to form C, N1, N2, and N3 groups. Results and discussion We found that layers in group N1 had higher egg production rate than those in group C. Egg weight was significantly reduced, while eggshell thickness was significantly improved, by treatment. However, the albumen height and Haugh unit were the lowest in group N3. Based on the above results, groups C and N1 were selected for further transcriptomics analysis of uterine tissue by RNA-seq. More than 7.4 Gb clean reads and 19,882 tentative genes were obtained using the Gallus gallus genome as a reference. Transcriptomics analysis in uterus tissue revealed that 95 differentially expressed genes (DEGs) were upregulated and 127 DEGs were downregulated. Functional annotation and pathway enrichment analysis showed that DEGs in uterine tissue were mainly enriched in glutathione metabolism, cholesterol metabolism, and glycerolipid metabolism, etc. Vitamin A metabolism-related gene, RBP1, nutrient transport-related gene, ALB, protein synthesis-related gene, METTL21C, and calcium transport-related gene, RYR2, CACNB2, RAMP3, and STAC, were significantly regulated by 0.08% NCG supplementation. Therefore, we concluded that NCG supplementation at a dose of 0.08% improved production performance and egg quality of layers by regulating uterus function.
Re-evaluation of Cerebropollenites thiergartii Eberh.Schulz 1967 and related taxa: priority of Sciadopityspollenites and nomenclatural novelties

Abstract The important marker species for the base of the Jurassic, Cerebropollenites thiergartii, occurs contemporaneously with at least nine related taxa. However, their distinction is difficult and has been confused in the past. In addition, a long history of numerous recombinations with different genus names (e.g. Tsugaepollenites and Sciadopityspollenites), and inconsistent classifications or synonymisations, further complicate the taxonomic framework of Cerebropollenites thiergartii. A comprehensive study of these ten taxa, summarising their crucial distinctive characteristics and potential synonymy, is currently missing. This limits the stratigraphic value of Cerebropollenites thiergartii and associated taxa relevant to the Triassic–Jurassic transition. Here, we revisit relevant holotype material, related taxa and investigated new material for potential interspecific and intraspecific morphological variation. Based on an empirical analysis of name use and an extensive literature review, we identified previous sources of confusion, re-evaluated the distinctive characteristics and stratigraphic value of these taxa, and their relevance for the Triassic–Jurassic transition. Finally, we argue that the recombination as Sciadopityspollenites thiergartii is taxonomically and nomenclaturally imperative, not only due to priority, but also because it unifies previous disjunct use of Cerebropollenites for Mesozoic and Sciadopityspollenites for Cenozoic taxa, or Mesozoic species in many Russian studies. Thus, we propose a series of nomenclatural novelties: Sciadopityspollenites emend. , Sciadopityspollenites thiergartii comb. nov. et emend. , S. thiergartii ssp. nov. thiergartii, S. thiergartii ssp. multiverrucosus stat. nov., S. megaorbicularius sp. nov., S. carlylensis comb. nov. et emend. , S. serratus emend. , S. macroverrucosus emend. , S. mesozoicus emend. , Cryptopalynites gen. nov., Cryptopalynites pseudomassulae comb. nov. et emend.
A Review of Application of Proteomicsin the World's Biggest Killer Diseases and Some Foods

 Abstract —The proteome is defined as all the proteins expressed by the genome, an organism or a cell type. Proteomics is the study of the proteome of a cell line, tissue or organism with the aim of integrating the search for biological processes. The term proteomics refers to a wide range of studies related to the isolation of proteins from a single sample and the comparison of protein expression profiles in different samples. The knowledge of proteomics identifies the properties, quality and quantity of proteins. In the past years, various methods have been developed for proteomic analysis. One of the main goals in proteomic studies is to identify the desired proteins through their amino acid sequence. Whole proteome analysis is a major challenge. The most commonly used methods are two-dimensional gel electrophoresis (2DE), surface-enhanced laser desorption/ionization (SELDI), liquid chromatography-mass spectrometry (LC-MS), selective reaction monitoring (SRM), monitoring Multiplex reaction (MRM) and protein arrays The first step in the proteomic analysis is the isolation of proteins in samples. Two-dimensional gel electrophoresis is one of the most common separation methods in this field, and isoelectric focusing (IEF) in the first dimension and SDS-polyacrylamide gel electrophoresis (SDS-PAGE) in the second dimension enables the separation of proteins by charge and size. Laser ionization and release methods by matrix-assisted laser desorption/ionization mass spectrometry (MALDI-TOF-MS) enable rapid ionization and identification of proteins and peptides. This article aims to comprehensively review proteomics in the worldof 's biggest killer diseases such as malaria, covid-19, Cancer and the some food items.
Synthetic Cinnamides and Cinnamates: Antimicrobial Activity, Mechanism of Action, and In Silico Study

The severity of infectious diseases associated with the resistance of microorganisms to drugs highlights the importance of investigating bioactive compounds with antimicrobial potential. Therefore, nineteen synthetic cinnamides and cinnamates having a cinnamoyl nucleus were prepared and submitted for the evaluation of antimicrobial activity against pathogenic fungi and bacteria in this study. To determine the minimum inhibitory concentration (MIC) of the compounds, possible mechanisms of antifungal action, and synergistic effects, microdilution testing in broth was used. The structures of the synthesized products were characterized with FTIR spectroscopy, 1 H-NMR, 13 C-NMR, and HRMS. Derivative 6 presented the best antifungal profile, suggesting that the presence of the butyl substituent potentiates its biological response (MIC = 626.62 μM), followed by compound 4 (672.83 μM) and compound 3 (726.36 μM). All three compounds were fungicidal, with MFC/MIC ≤ 4. For mechanism of action, compounds 4 and 6 directly interacted with the ergosterol present in the fungal plasmatic membrane and with the cell wall. Compound 18 presented the best antibacterial profile (MIC = 458.15 μM), followed by compound 9 (550.96 μM) and compound 6 (626.62 μM), which suggested that the presence of an isopropyl group is important for antibacterial activity. The compounds were bactericidal, with MBC/MIC ≤ 4. Association tests were performed using the Checkerboard method to evaluate potential synergistic effects with nystatin (fungi) and amoxicillin (bacteria). Derivatives 6 and 18 presented additive effects. Molecular docking simulations suggested that the most likely targets of compound 6 in C. albicans were caHOS2 and caRPD3, while the most likely target of compound 18 in S. aureus was saFABH. Our results suggest that these compounds could be used as prototypes to obtain new antimicrobial drugs.
Classifying C1+ structures on dynamical fractals: 1. The moduli space of solenoid functions for Markov maps on train tracks

Abstract Sullivan's scaling function provides a complete description of the smooth conjugacy classes of cookie-cutters. However, for smooth conjugacy classes of Markov maps on a train track, such as expanding circle maps and train track mappings induced by pseudo-Anosov systems, the generalisation of the scaling function suffers from a deficiency. It is difficult to characterise the structure of the set of those scaling functions which correspond to smooth mappings. We introduce a new invariant for Markov maps called the solenoid function. We prove that for any prescribed topological structure, there is a one-to-one correspondence between smooth conjugacy classes of smooth Markov maps and pseudo-Hölder solenoid functions. This gives a characterisation of the moduli space for smooth conjugacy classes of smooth Markov maps. For smooth expanding maps of the circle with degree d this moduli space is the space of Hölder continuous functions on the space {0,…, d − 1}ℕ satisfying the matching condition.
The application and trend of ultra-weak photon emission in biology and medicine

Ultra-weak bioluminescence, also known as ultra-weak photon emission (UPE), is one of the functional characteristics of biological organisms, characterized by specialized, low-energy level luminescence. Researchers have extensively studied UPE for decades, and the mechanisms by which UPE is generated and its properties have been extensively investigated. However, there has been a gradual shift in research focus on UPE in recent years toward exploring its application value. To better understand the application and trend of UPE in biology and medicine, we have conducted a review of relevant articles in recent years. Among the several topics covered in this review is UPE research in biology and medicine (including traditional Chinese medicine), primarily focused on UPE as a promising non-invasive tool for diagnosis and oxidative metabolism monitoring as well as a potential tool for traditional Chinese medicine research.
Cognitive Performance in Patients With Sporadic Vestibular Schwannoma

BACKGROUND: To date, few data are available on the cognitive function of patients with vestibular schwannoma (VS) before treatment. OBJECTIVE: To provide a cognitive profile of patients with VS. METHODS: This cross-sectional observational study recruited 75 patients with an untreated VS and 60 age-, sex-, and education-matched healthy control subjects. A set of neuropsychological tests were administered to each participant. RESULTS: Compared with the matched controls, patients with VS exhibited impaired general cognitive function, memory, psychomotor speed, visuospatial ability, attention and processing speed, and executive function. The subgroup analyses displayed that patients with severe-to-profound unilateral hearing loss were more cognitively impaired than patients with no-to-moderate unilateral hearing loss. In addition, patients with right-sided VS scored worse than those with left-sided VS on tests of memory, attention and processing speed, and executive function. No differences were observed in cognitive performance between patients with or without brainstem compression and those with or without tinnitus. We also found that worse hearing and longer hearing loss duration were associated with poorer cognitive performance in patients with VS. CONCLUSION: The findings of this study provide evidence for cognitive impairment in patients with untreated VS. It can thus be said that including cognitive assessment in the routine clinical management of patients with VS may facilitate more appropriate clinical decision-making and improve patients' quality of life.
Impact of High-Frequency Trading with an Order Book Imbalance Strategy on Agent-Based Stock Markets

It is known that there is a positive correlation between order book imbalance and future returns. Although some previous studies using actual trading data have suggested that high-frequency trading (HFT) may take this characteristic into account, HFT firms have not disclosed their specific strategies. Furthermore, there has been a long-standing debate in the empirical research field as to whether HFT is the cause of flash crashes, but no final conclusion has been reached. In the present study, we analysed the impacts of HFT taking into account the correlation between order book imbalance and future returns on a stable market and on a market with a flash crash, using agent-based simulations, which are said to be capable of analysing events in their essence. We also analysed how HFT investment performance differs between those two market conditions. The results showed that HFT has the effect of further stabilizing the market when the market is stable but does not take place during flash crashes and so is unable to affect the market either for the good or the bad. The results also suggest that the proposed HFT’s performance is more sensitive to market price fluctuations than conventional HFT (i.e., HFT following a position market-making strategy) and tends to have high risk and high returns.
LES study of breakdown control of A-pillar vortex

Active flow control of the longitudinal vortices that developed near and around simplified A-pillar of a generic vehicle was studied using large eddy simulation (LES). The LES results were validated against existing Particle Image Velocimetry (PIV) and aerodynamic drag data. The LES results were further used to study the flow physics responsible for the development of longitudinal vortices, in particular the vortex breakdown process. Tangential blowing and suction into the shear layer rolling into the longitudinal vortices was found to be a sensitive process that can cause instabilities in the flow. The resulting LES flows also show that actuation influences not only the longitudinal vortex nearest to the actuation slot but also the overall flow. Thus, the influence of the flow control actuation on the entire flow must be considered in order to be able to find the appropriate level of control for optimal aerodynamic performance.
The nonexistence of certain invariant measures

It is shown that there does not exist an uncountable group G and a nontrivial, a-finite, countably additive measure defined on all subsets of G which is left-invariant . The purpose of this note is to resolve a point left unclear in a recent paper of F. Terpe [1] and its review [2] . In [1], F. Terpe shows that the existence of a certain "maximal" integral is equivalent to the existence of a nontrival countably additive a-finite measure m, defined on all subsets of the interval I = [0, 1) and invariant under translation mod 1 . In his review [2] of this paper, J . C. Oxtoby points out that the proof given there for the nonexistence of such a measure tacitly presupposes that the a-field 2' x 2' of subsets of I x I generated by generalized rectangles is invariant under the shear map S, where S (x, y) = (x + y, y) and addition is mod 1, and that by a theorem of Iwanik [3] this instance of Weil's measurability condition is satisfied if and only if all subsets of I x I belong to 2' x 2'. Thus, Terpe's reasoning actually established the nonexistence of m, only under the hypothesis 2"' = 2' x 2'. Finally, Oxtoby points out in his review that 2' x, = 2' x 2' is implied by CH, but that CH makes the group argument unnecessary . Oxtoby ends his review by stating that the situation is unclear without CH . We give a short argument below to show that no such hypothesis is needed . THEOREM . Suppose G is an uncountable group and tt is a a-finite countably additive left-invariant measure defined on all subsets of G . Then It is trivial . PROOF . Let M be a subgroup of G of cardinality m l . Let R be the family of all right cosets of M and let A be a subset of G which intersects each set in R in exactly one point . Let 'C = { mA : m e M} . Then X is a family of Kl disjoint sets covering G and if Hl and H 2 belong to 'C, then H 2 is a left translate of H 1 . Let { K„ } ° 1 be a sequence of sets of finite measure covering G . For each n, the sets of the form K„ n H, where H E X form a decomposition of K„ and therefore there are not uncountably many H's with tt(K„ n H) > 0 . Thus, there is a set Ho in 'JC with tt(K„ n Ho) = 0 for each n . Therefore, μ(H) = 0 for all H E'C . This implies that N1 is a real-valued measurable Received by the editors September 30, 1975 and, in revised form, January 30, 1976 . AMS (MOS) subject classifications (1970) . Primary 28A25, 28A70 ; Secondary 04A10 .
Updated Evaluation of the Safety, Efficacy and Tolerability of Tafamidis in the Treatment of Hereditary Transthyretin Amyloid Polyneuropathy

Abstract Hereditary amyloid transthyretin (ATTRv) amyloidosis is a devastating hereditary multisystemic disease affecting predominantly the peripheral and autonomic nervous systems and the heart. ATTRv is caused by mutations in the transthyretin (TTR) gene, leading to extracellular deposition of amyloid fibrils in multiple organs including the peripheral nervous system. If untreated, it is associated with a fatal outcome 10–12 years after disease onset. Different treatments are available for patients with ATTRv polyneuropathy. Tafamidis 20 mg is approved in Europe since 2011 for early stages of ATTRv polyneuropathy (stage I – able to walk without support) and it is recommended as first-line therapy in these patients. Tafamidis is a TTR stabilizer that selectively binds to TTR and kinetically stabilizes both wild-type native TTR and mutant TTR. Consequently, it has the potential to prevent the amyloidogenic cascade initiated by TTR tetramer dissociation into its monomers and subsequent misfolding and aggregation. Tafamidis is an oral drug, taken once per day, with proved efficacy, safety and tolerability in ATTRv-PN patients as demonstrated in different clinical trials and open-label extension studies as well in clinical practice setting with around 10 years of experience. Tafamidis treatment started in the earliest stages of the disease is associated with better neurological outcomes. A multidisciplinary approach in referral centres is also fundamental for monitoring patients to assess individual response to treatment.
Investigation of Flow Through Centrifugal Pump Impellers Using Computational Fluid Dynamics

With the aid of computational fluid dynamics, the complex internal flows in water pump impellers can be well predicted, thus facilitating the design of pumps. This article describes the three-dimensional simulation of internal flow in three different types of centrifugal pumps (one pump has four straight blades and the other two have six twisted blades). A commercial three-dimensional Navier-Stokes code called CFX, with a standard k – e two-equation turbulence model was used to simulate the problem under examination. In the calculation, the finite-volume method and an unstructured grid system were used for the solution procedure of the discretized governing equations for this problem.Comparison of computational results for various types of pumps showed good agreement for the twisted-blade pumps. However, for the straight-blade pump, the computational results were somewhat different from widely published experimental results. It was found that the predicted results relating to twisted-blade pumps were better than those relating to the straight-blade pump, which suggests that the efficiency of a twisted-blade pump will be greater than that of a straight-blade pump. The calculation also predicts reasonable results in both the flow pattern and the pressure distribution.
A NEKHOROSHEV THEOREM FOR SOME INFINITE-DIMENSIONAL SYSTEMS

We study the persistence for long times of the solutions of some infinite- dimensional discrete hamiltonian systems with formal hamiltonian 1=1 h(Ai) + V ('), (A, ') 2 RN × TN. V (') is not needed small and the problem is perturbative being the kinetic energy unbounded. All the initial data (Ai(0), 'i(0)), i 2 N in the phase-space RN × TN, give rise to solutions with |Ai(t) Ai(0)| close to zero for exponentially-long times provided that Ai(0) is large enough for |i| large. We need @h @Ai (Ai(0)) unbounded for i ! +1 making 'i a fast variable; the greater is i, the faster is the angle 'i (avoiding the resonances). The estimates are obtained in the spirit of the averaging theory reminding the analytic part of Nekhoroshev-theorem. 1. Introduction. In the study of hamiltonian ordinary differential equations, two of the main problems are: 1) to prove the existence of the solutions for a time as long as possible 2) to understand the qualitative properties of the solutions found. As a model problem let's consider the hamiltonian H(A,') = h(A)+"V ('), ' ∈ T N , A ∈ U = o
Clinical Characteristics of the Cervical Inlet Patch: A Case Series

Abstract Objective The goal of this study was to characterize the symptoms and outcomes of patients with a symptomatic cervical inlet patch (CIP). Study Design Retrospective case series. Setting Tertiary care laryngology clinic in Charlottesville, Virginia. Methods A retrospective chart review of the patient's demographics, comorbidities, prior workup, interventions, and response to treatment was performed. All patients received flexible nasolaryngoscopy and barium swallow study. The analysis was descriptive. Results Eight patients (6 female) were followed for the management of symptoms related to CIP. The mean age at presentation to our clinic was 64.9 (standard deviation = 15.7). Five out of 8 patients presented with a chief complaint of dysphagia, and the remaining 3 with chronic coughs. Five out of 8 patients demonstrated findings of laryngopharyngeal reflux (LPR) including vocal fold edema, mucosal erythema, or postcricoid edema. Swallow study demonstrated hiatal hernia in 3 of 8 patients, and cricopharyngeal (CP) dysfunction (CP hypertrophy, CP bar, and Zenker's diverticulum) in 3 of 8 patients. One patient presented with a history of Barrett's esophagus. Treatment included increased acid suppression therapy and management of coexisting esophageal pathologies. Ablative procedures were performed in 5 out of 8 cases, with 2 patients requiring repeat procedures. All patients experience subjective symptom improvement. Conclusion CIP tends to present in complex patients with multifactorial dysphagia, with the most common symptoms being dysphagia and cough. Clinical features of CIP overlap with other more common pathologies encountered by otolaryngologists including LPR and CP dysfunction, and future prospective studies in larger populations should seek to clarify these associations.
Implicit High-Order Spectral Finite Volume Method for Inviscid Compressible Flows

The present work has the objective of demonstrating the capabilities of a spectral finite volume scheme implemented in a cell-centered finite volume context for unstructured meshes. The two-dimensional Euler equations are considered to represent the flows of interest. The spatial discretization scheme is developed to achieve high resolution for flow problems governed by hyperbolic conservation laws. Roe's flux difference splitting method is used as the numerical approximate Riemann solver. Several applications are performed in order to assess the method capability compared to data available in the literature and also compared to an weighted essentially nonoscillatory scheme. There is good agreement with the comparison data, and efficiency improvements over the weighted essentially nonoscillatory method are observed. The features of the present methodology include an implicit time-marching algorithm; second-, third-, and fourth-order spatial resolution; exact high-order domain boundary representation; and a hierarchical moment limiter to treat flow solution discontinuities.