Miracle-dz/UniFAR-FTUs huggingface dataset:
Efficacy of Mesenchymal-Stromal-Cell-Derived Extracellular Vesicles in Ameliorating Cisplatin Nephrotoxicity, as Modeled Using Three-Dimensional, Gravity-Driven, Two-Layer Tubule-on-a-Chip (3D-MOTIVE Chip)

Mesenchymal stromal cell (MSC)-derived extracellular vesicles (EVs) are known to have a therapeutic effect on nephrotoxicity. As animal models require significant time and resources to evaluate drug effects, there is a need for a new experimental technique that can accurately predict drug effects in humans. We evaluated the therapeutic effect of MSC-derived EVs in cisplatin nephrotoxicity using a three-dimensional, gravity-driven, two-layer tubule-on-a-chip (3D-MOTIVE chip). In the 3D-MOTIVE chip, 10 μM cisplatin decreased the number of attached cells compared to the vehicle. Conversely, annexin V and reactive oxygen species (ROS) were increased. Cell viability was increased 2.8-fold and 2.5-fold after treatment with EVs at 4 and 8 µg/mL, respectively, compared to the cisplatin-induced nephrotoxicity group. Cell attachment was increased 2.25-fold by treatment with 4 µg/mL EVs and 2.02-fold by 8 µg/mL EVs. Annexin V and ROS levels were decreased compared to those in the cisplatin-induced nephrotoxicity group. There were no significant differences in annexin V and ROS levels according to EV concentration. In sum, we created a cisplatin-induced nephrotoxicity model on a 3D-MOTIVE chip and found that MSC-derived EVs could restore cell viability. Thus, MSC-derived EVs may have the potential to ameliorate cisplatin-induced nephrotoxicity.
Association between Surface Ozone and Solar Activity

The possible relationship between surface ozone and smoothed sunspot numbers (SSN) has been studied. The sunspot data were collected from Udaipur Solar Observatory for 1996-2004. Surface ozone has been measured at Tranquebar (11°N, 79.9 °E), a tropical rural coastal site on the east coast of southeast India, during the same period. The measurements have shown that there exists a significant diurnal cycle/oscillation of average ozone with a maximum concentrations in the afternoon and average minimum ozone concentration at sunrise. Ozone measurements have also shown that the average higher concentrations [23 ± 9 ppbv] in May and lower concentration (17±7 ppbv) in October at this site. Further, the increase in surface ozone in association with increase in sunspot numbers is observed during May and October.
Effects of preloading and consolidation on the uplift capacity of skirted foundations

Centrifuge tests investigating the effect of compressive preloading and consolidation on the subsequent uplift capacity of shallow skirted foundations that rest on lightly over-consolidated kaolin clay are reported. The uplift resistance, total and pore pressures at the foundation invert were monitored during the installation, consolidation and uplift. The results show that uplift performed immediately after the preloading generates a lower capacity due to the remoulding of the clay and reduction in soil strengths that result from the application of preloading. The soil strength can be recovered and eventually enhanced by the subsequent consolidation process. A theoretical framework, where the variation of the soil operative strength with preloading and consolidation is interpreted using the critical state concept, is proposed to explain and justify the experimental observations. The framework is validated through retrospective prediction of the uplift resistance of the centrifuge model tests with good ag.
Faunal analysis from Amud Cave: preliminary results and interpretations

The Late Mousterian Neanderthal site of Amud Cave (dated ca. 70–55 kyr) is situated on the margins of the Dead Sea Rift, about 5 km northwest of the Sea of Galilee. Recent excavations at the site yielded rich lithic, faunal and human skeletal assemblages. This paper presents some characteristics of the faunal assemblages from Amud Cave, combined with pertinent results of taphonomic and micromorphological studies, and places them in the context of other Late Mousterian archaeofaunas in the southern Levant. Copyright © 2004 John Wiley & Sons, Ltd.
On the presence of intermediate-scale heterogeneity in the upper mantle

SUMMARY Power spectra of tomographic models of the entire earth and of models of Europe and the Mediterranean area are compared. This comparison reveals a discrepancy (a factor 15–30) between the power of both kinds of models at intermediate spherical-harmonic degrees (around l = 30). Two possible explanations for this discrepancy are given: first, the fact that Europe is more complex than the global average; and second, the lack of resolution in the inversions. Another approach to the problem of the power spectrum of heterogeneities of intermediate length scale is the study of multipathing of long-period surface waves. The multipathing observed in the recordings of these waves, which manifests itself as an increasing complexity of their amplitude spectra due to increasing interference of spectral components with increasing epicentral distance, cannot be explained by present-day global earth models. The gradients in the models are simply not strong enough. However, random models with more power at intermediate scales, and consequently stronger gradients, are able to explain the observed multipathing. It is concluded that the global models underestimate the power in the heterogeneities of intermediate-scale structure in the earth. Finally, an explanation is given why current global models, although they do not contain sufficient power at shorter scales, do explain the traveltime and dispersion data used for the construction of the models.
Critical Care Nurses' Compliance with Blood Transfusion Guidelines in Gastrointestinal Intensive Care Units

1.ABSTRACT Background : For critically ill patients undergoing gastrointestinal surgery, blood transfusions are frequently necessary to correct anemia or replace significant blood loss from related trauma or surgical operations. Ensuring the safety of blood transfusion procedures is the role of critical care nurses in the intensive care unit (ICU). Aim : The current study aimed to investigate critical care nurses’ compliance with blood transfusion guidelines in Gastrointestinal ICUs. Method : A descriptive observational research design was used to conduct this study with a convenience sample of 49 critical care nurses working in three ICUs affiliated with a university hospital in Egypt. Critical care nurses' compliance with the blood transfusion practice tool was used to collect data for this investigation. Results : Most of the participant nurses (81.6%) had satisfactory practice levels regarding their compliance with blood transfusion guidelines with a total mean practice score of 86.5±2.1. All participant nurses showed a satisfactory level of practice regarding patient identification, and collection, delivery, and administration of blood components. However, 91.8% of the participant nurses had unsatisfactory practice levels regarding checking blood requests and documentation. Conclusion and Recommendations : The study highlights the need for periodic refresher training sessions for critical care nurses on updated blood transfusion guidelines with a specific focus on checking blood requests and documentation of blood transfusion. This will enhance nurses’ practice, optimize patient safety and reduce blood transfusion-related complications in ICUs.
Contribution of BAP1 loss and p16 (CDKN2A) deletion analysis to the definitive diagnosis of mesothelioma in effusion cytology.

OBJECTIVE The cytological diagnosis of mesothelioma is a controversial issue, and definitive diagnosis often requires ancillary tests. The aim of this study was to investigate the contribution of BRCA1-associated protein (1) (BAP1) loss and p16 (CDKN2A) homozygous deletion (HD) on the early diagnosis of mesothelioma in effusion fluids. MATERIALS AND METHODS Between 2019-2022, 21 pleural and peritoneal fluid samples diagnosed with atypical mesothelial proliferation in our institution were included in the study. The slides of the cases that underwent BAP1 immunohistochemistry (IHC) were retrieved from the archive and re-examined. Homozygous deletion (HD) of p16 (CDKN2A) was investigated by the fluorescence in situ hybridization (FISH) method in cell blocks of cytology samples. At least 100 atypical mesothelial cells were counted in each case, and the HD threshold value was >10%. RESULTS The mean age of the cases was 63.47 years (34-90 years), female/male ratio was 3/1. Of the pleural mesothelioma cases, 16 were epithelioid, 2 were biphasic, and 1 were sarcomatoid. Two cases were diagnosed with peritoneal well-differentiated papillary mesothelioma (WDPM). BAP1 loss was observed in 11 (69%) of 16 cases. HD deletion of p16 (CDKN2A) was seen in 11 (58%) patients with FISH. The HD threshold value was 10-20% in 6 of the cases, 30-50% in 3 cases, and above 90% in 2 cases. While HD deletion was observed in p16 (CDKN2A) in all biphasic and sarcomatoid cases (n=3), no deletion was observed in peritoneal WDPM (n=2). Positivity was observed with at least one method in 12 (86%) of 14 pleural mesotheliomas who underwent both BAP1 IHC and p16 (CDKN2A) FISH. Due to technical reasons, the FISH signal could not be obtained in two cell blocks, so no results could be obtained. CONCLUSIONS Asbestos exposure in areas where mesothelioma is endemic and/or the presence of proliferating mesothelial cells in cytological examination are important clues for diagnosis. In controversial cases, BAP1 IHC should be the first step in an ancillary test. Although the FISH method applied to cell blocks has cytology-specific limitations and difficulties, investigating the p16 (CDKN2A) deletion with FISH in selected cases will contribute to the diagnosis.
Microbiological and molecular characterization of E. coli and Salmonella isolated from diarrheic calves

Diarrhea is one of the most common fatal disease of neonatal calves regardless of farm welfare. What makes treatment of these cases challenging is the increase in the incidence of multi-drug resistant bacteria, including E. coli and Salmonella. To isolate, identify, molecular characterize of E. coli and salmonella in diarrheic calves, 50 fecal samples were collected and analyzed aseptically. The preliminary result showed that 62% and 14% samples were positive for E. coli and salmonella respectively. Among the E.coli isolates O86:K59, O128:K, O55:K59 (2), O86:K61, O119:K58, O08:K61, O126:K71 serotypes was detected in eight isolates while one isolate was untypeable. Three salmonella serotypes, Salmonella Typhimurium, Salmonella Anatum and Salmonella Florida was detected in the isolated samples . All of the E. coli strains had eaeA genes while 16.7 and 11.1% of them harbored stx1 and stx2 genes respectively. About 71.4% of salmonella isolates were positive for all five pathogenicity island genes from SPI-1 to SPI-5, while SPI-1, SPI-2 and SPI-5 were detected in 14.3% and SPI-2, SPI-3, SPI-4 and SPI-5 were positive in 14.3%. All E. coli strains were resistant to Ampicillin, Amoxicillin/Clavulanic, Cefazolin and Aztreonam. , and all Salmonella serovars were resistant to Cefazolin, Chloramphenicol, Gentamycin, Kanamycin and Aztreonam. The present study identified multidrug resistant E. coli and salmonella as the common pathogen of calf diarrhea in the study area and the pathogens harbored common virulence markers of human diarrheic strains which might cause a food borne outbreak in the future.
Pan-cancer analysis and in vitro validation of the oncogenic and prognostic roles of AURKA in human cancers

Background Aurora kinase A (AURKA) plays a pivotal role in regulating cell mitosis and tumor progression. However, its prognostic significance across diverse cancer types remains relatively unexplored. Methods We conducted a comprehensive analysis of AURKA expression in various cancers using data from The Cancer Genome Atlas, Genotype-Tissue Expression, and The Human Protein Atlas databases. Our investigation encompassed an exploration of the associations between AURKA expression and clinical characteristics, shedding light on potential functional roles of AURKA. Additionally, we delved into the relationship between AURKA and the tumor microenvironment. To substantiate the role of AURKA, we carried out in vitro experiments in esophageal adenocarcinoma (EAC), prostate cancer (PRAD), and pancreatic cancer (PAAD) cells. Results Our analysis revealed that AURKA is prominently overexpressed in a majority of the cancer types under investigation. Elevated AURKA expression correlated closely with poorer prognosis and advanced tumor stages. AURKA was found to be associated with key pathways involved in the cell cycle and arachidonic acid metabolism. Moreover, AURKA expression exhibited significant correlations with immunoregulatory genes and immune cell profiles. Notably, in vitro experiments demonstrated that silencing AURKA expression resulted in reduced cell viability in EAC, PRAD, and PAAD cells, as well as a decrease in clone formation, cell cycle elongation, diminished cell invasion and reduced spheroid size in EAC cells (OE33 and OE19). Conclusion Our study elucidates the oncogenic role of AURKA and underscores its prognostic value across a spectrum of cancers, including EAC. These findings suggest that AURKA holds promise as a predictive biomarker for EAC and various other tumor types.
Design of Inclined Platefor seeder by Analyzing Investigation of Physical and Frictional properties of Mustard Seed Varieties to Design Inclined Plate Metering Mechanism

This study exploredsTthe physical and frictional properties were studied forof three distinct mustard seed varieties: RLC-1, GSC-7, and PBR-91, with the primary objective of designing an efficient inclined plate for seed metering mechanismfor in agricultural seeders. Mustard, a globally significant oilseed crop, plays a vital role in both agriculture and industry. Our comprehensive analysis encompassed various seed properties, including seed dimensions, test weight (1000 seed) weights, moisture content, geometric mean diameters, surface area, bulk density, true density, sphericity, angle of repose, and coefficients of friction on plywood and GI sheet surfaces. The results revealed significant variations among the mustard seed varieties. For instance, RLC-1 seeds exhibited lengths of 4.029 ± 0.37 mm, widths of 2.210 ± 0.31 mm, and thicknesses of 0.851 ± 0.19 mm, whereas GSC-7 displayed lengths of 4.110 ± 0.42 mm, widths of 2.300 ± 0.35 mm, and thicknesses of 0.910 ± 0.24 mm. Additionally, GI sheet surfaces exhibited a lower coefficient of friction compared to plywood. This comprehensive dataset informs the design of tailored seed metering mechanisms, optimizing seed handling, minimizing seed damage and losses, and reducing blockagejamming during agricultural seeding operations, thereby enhancing overall efficiency in mustard crop cultivation and seedingowing technology.
Growth stratal records of instantaneous and progressive limb rotation in the Precordillera thrust belt and Bermejo basin, Argentina

Analysis of synorogenic deposits preserved near the thrust front zone of the Precordillera fold and thrust belt and in the Bermejo foreland basin in central Argentina documents the evolution of deformation during the last 5 Myr as well as the thrust system kinematics. Seismic lines across the area display examples of progressive and instantaneous limb rotations. The easternmost thrust plate of the Central Precordillera, the Niquivil thrust, experienced episodic motion in two main stages: a first thrust movement as a fault-propagation fold and a second movement as a high-angle anticlinal breakthrough fault after a period of quiescence. Growth strata deposited in the La Pareja intermontane basin and the Las Salinas and Bermejo anticline recorded continuous growth of Eastern Precordilleran structures beginning at ∼2.7 Ma, with uplift rates of ∼0.3 mm/yr for the Niquivil anticline, 1.08 mm/yr for the Las Salinas anticline, and between ∼0.6 and 0.38 mm/yr during the last ∼2 Myr for the Bermejo anticline. Once the Eastern Precordillera began to grow, the propagation of the Niquivil thrust stopped, restricting the deformation to the young Vallecito out-of sequence thrust. The complex geometry of growth strata deposited on the back limb of the Las Salinas anticline can be explained by using a model of a two-step fault propagation fold with constant layer thickness. The Bermejo anticline of the Eastern Precordillera is formed by the simultaneous propagation of a shallow fault, responsible for the fold shape, and a deep fault that produced vertical uplift. A growth triangle that documents instantaneous forelimb rotation for a fault-propagation fold is recorded for the first time in a published seismic line.
Evaluation of Indian bean ( Dolichos lablab L.) genotypes for growth and yield performance under east and south eastern coastal plain zones of Odisha

Evaluation of Twelve genotypes of Dolichos bean (Dolichos lablab L.) were done for growth and yield parameters under south eastern coastal zones of Odisha. The results revealed that there was considerable variability existing among the genotypes of Indian bean. Significant differences were also found among the genotypes analyzed for fourteen quantitative characters as well as in seven qualitative characters. The results of the experiment showed that the mean performance of growth parameters at last harvest like plant height, number of compound leaves, number of primary branches per plant, average leaf area, Days to first flowering, Days to 50% flowering were 60.21 to 73.15 cm, 16.20 to 20.07, 3.80 to 7.93, 102.81 to 267.90 cm 2 , 37.20 days to 44.27 days, 42.47 to 48.93 days respectively. The yield parameters viz., Inflorescence length, Number of flowering nodes per inflorescence, Number of pods per inflorescence, Number of pods per plant, Pod length, Pod width, Pod yield per plant, Pod yield in tons per hectare were ranged from, 19.24 to 26.90 cm, 6.13 to 9.53, 5.20 to 9.60, 22.33 to 67.00, 4.20 cm to 13.00 cm, 1.30 cm to 3.10 cm, 0.04 to 0.48 kg and 5.50 t/ha to 13.00 t/ha, respectively. The genotypes 2017/DBB VAR-5 (0.48 kg), 2018/DOL B VAR-2 (0.46 kg) and 2017/DBB VAR-6 (0.43 kg) were found promising for pod yield per plant than other genotypes. These three varieties also showed better growth and yield attributing characters in comparison to other varieties. The genotype 2017/DBB VAR-5 showed variably purple color pods in contrast to rest of the genotypes and can be used in crop improvement programme for developing anthocyanin rich Dolichos bean pods. There is a need to evaluate these high yielding genotypes in larger plots and over multi locations in Odisha for their commercial utilization.
Lake and Bulk Sampling Chemistry, NADP, and IMPROVE Air Quality Data Analysis on the Bridger-Teton National Forest (USFS Region 4)

Air quality monitoring data from several programs in and around the Bridger-Teton (B-T) National Forest—National Atmospheric Deposition Program (NADP), longterm lake monitoring, long-term bulk precipitation monitoring (both snow and rain), and Interagency Monitoring of Protected Visual Environments (IMPROVE)— were analyzed in this report. Trends were analyzed using non-parametric tests and seasonality was taken into account when possible. Nitrate (NO3 -) showed seasonal increasing trends in all sampled lake inlets, in atmospheric deposition at NADP sites and bulk sampling sites, and at two visibility sites. NADP sites showed consistent decreasing trends for both deposition and concentrations in SO4 2-, Na+, Mg2+, and Cland increasing trends in NH4 + and inorganic nitrogen deposition. Lake and bulk deposition chemistry data showed increasing trends in cations and decreasing trends in Cl-. Bulk deposition sites showed an increasing trend in NH4 +. Standard Visual Range (SVR) showed an increasing trend and extinction showed a decreasing trend at all IMPROVE sites analyzed. In conclusion, considerations were listed regarding current and future air quality monitoring on the B-T National Forest.
Sensitivity of the Atlantic meridional overturning circulation to surface forcing

The determination of the mechanisms setting the strength and structure of the large scale circulation is a fundamental and long-standing problem in physical oceanography. In this thesis, we seek to explore the mechanisms contributing to the steady state and variability of the large scale flow, with a focus on better understanding the dynamics of the Atlantic meridional overturning circulation (AMOC). In the first part of this thesis, we explore the linear sensitivity of the monthly mean subtropical AMOC to surface fluxes of buoyancy and momentum. Our approach is to use a numerical adjoint. Key insights are provided into the memory of the AMOC to historic atmospheric forcing. We find that significant memory to wind forcing is confined to timescales of less than a year. In contrast, we identify significant memory to surface buoyancy forcing spanning multi-decadal timescales and characterised by a large scale oscillation in the sign of sensitivity between the eastern and western North Atlantic basin. An important result is that to understand the origins of seasonal variability in the modelled AMOC, we must examine the response to a multidecadal history of atmospheric forcing. In the second part of this thesis, a new tool is presented that enables a clean diagnosis of the force balance controlling the circulation regime for a Boussinesq fluid. Specifically, the tool is based on the development of the "rotational momentum" equations and sets of scalar "velocity potentials" and analogous "force functions". The latter allow the projection of all forces onto the acceleration of the vertical shears and external modes of overturning to be visualised in isolation. The rotational momentum decomposition is applied to the modelled circulation in idealised Atlantic and global configurations of the MITgcm, with a focus on elucidating the dynamics of the simulated AMOC. We discuss the key role played by the rotational buoyancy forcing right on the western boundary.
Silodosin in the treatment of benign prostatic hyperplasia

: Benign prostatic hyperplasia (BPH)-associated lower urinary tract symptoms (LUTS) are highly prevalent in older men. Medical therapy is the first-line treatment for LUTS due to BPH. Alpha-adrenergic receptor blockers remain one of the mainstays in the treatment of male LUTS and clinical BPH. They exhibit early onset of efficacy with regard to both symptoms and flow rate improvement, and this is clearly demonstrated in placebo-controlled trials with extensions out to five years. These agents have been shown to prevent symptomatic progression of the disease. The aim of this article is to offer a critical review of the current literature on silodosin, formerly known as KMD-3213, a novel alpha-blocker with unprecedented selectivity for α 1A -adrenergic receptors, as compared with both α 1B - and α 1D -adrenoceptors, exceeding the selectivity of all currently used α 1 -blockers, and with clinically promising effects.
Fauna of protected areas - 3: Spiders of Purna Wildlife Sanctuary, Dangs, Gujarat

1259 Received 14 August 2002; Revised received 23 November 2002; Finally accepted 24 August 2003 Abstract The spider diversity of Purna Wildlife Sanctuary, Dangs, Gujarat as recorded in 2000-2001 is 116 species belonging to 66 genera and 25 families. Family Araneidae was found to be dominating. Rare spiders like Rhene khandalaensis and Stegodyphus mirandus are first records for Gujarat. A burrow of ground Therasphosid was also sighted.