Miracle-dz/UniFAR-FTUs huggingface dataset:
Recurrence of HEr2+ pAtients: evaluation of Long term outcome In patients receiving trastuzumab TherapY

Background Despite improved prognosis of HER2+ eBC since the introduction of trastuzumab in the adjuvant setting in 2006, disease recurrences still occur in some patients after a few years. We aimed to describe in real life the long-term follow-up to assess disease-free and metastasis-free survival of patients with HER2+ eBC treated with adjuvant trastuzumab. Methods This was a multicenter, retrospective, cohort study assessing HER2+ eBC patients diagnosed between 2009 and 2010 and treated with adjuvant trastuzumab. Data were collected from patient’s medical charts. Disease-free survival (DFS), and metastatic-free survival (MFS) were evaluated in the overall population and within subgroups according to hormonal and nodal status. Results In the overall population (n=2,311) at 7 years, the DFS rate was 76.3% [95%CI 74.5%-78.2%], and the MFS rate was 84.2% [82.6%-85.8%]. According to hormonal status, the 7-year DFS rate was significantly higher in hormone-receptor positive (HR+) than hormone-negative (HR-) patients [80.5% vs . 69.2%; p <0.001 ], and the 7-year MFS rate [88.0% for HR+ vs . 77.7% HR-]. According to nodal status, the 7-year DFS rate was significantly higher for N- than for N+ patients [87.2% vs . 66.8%; p <0.001], and the 7-year MFS rate [94.7% for N- vs . 74.9% for N+; p <0.001]. Conclusions Despite introduction of adjuvant trastuzumab, prognosis of HER2+ eBC is still a matter above all in subgroups associated with a higher risk of disease recurrence. Our real-world study pointed out a particularly aggressive profile of N+ and HR- subgroups and the need for more efficient approaches for these particular group of patients.
Cyber-Bullying: Issues and Solutions for the School, the Classroom and the Home

Dedication in Memory of Hamed Nastoh 1. Cyber-Space: Battleground or Opportunity? 2. Profile of Traditional and Cyber-Bullying 3. A Transnational Snapshot 4. Shaping Gender Roles at Home and on the Internet 5. Controlling Kid's Spaces 6. Stakeholder Power 7. Balancing Free Expression: Privacy and Safety in Cyber-Space 8. Harmonious Solutions
Residual stress caused magnetic field abnormal change upon arc welding joints

Residual stress concentration of welding joints is an essen tial factor to structure safety. It was found that the residu al stress could generate a change of magnetic field in arc weldin g. Things became simple because of the methods based on measuring the distribution of the surface fields and analyzi ng the relation between the fields and the stress. However, we believe the fact that the magnetizing field caused by electrical curr ent in arc welding has effects can not be ignored. Also, the magnetic field of the Earth is sometimes considered as a critical point in the field's change. In this paper, experiments were carried out to study the role of arc current by comparing the methods of arc welding and laser welding. The magnetic field was measured upon the weldi ng sites. By controlling the input energy, the residual stre ss was almost the same. The results obtained from these two welding methods varied. Magnetic fields testing from arc welding specimens were changed more sharply than the laser ones. This means that the magnetic change caused by electrical arc current is important to the surface field. Therefore, by analyzing th e status of arc current, electro-magnetic methods can be used as non-destructive testing tool of the arc welding joints mere ly by testing the surface magnetic field without specific magn etization.
New Media and Popular Imagination: Launching Radio, Television, and Digital Media in the United States

Introduction 1. Cinema and Wireless in Turn of the Century Imagination 2. The Wireless Nation: Defining Radio as a Domestic Technology 3. The Amateur, the Housewife, and the Salesroom Floor: The Hesitations of Postwar US TV 4. US Television Abroad: 1960 - 1990 5. 'Mission number one is to kill TV': Remaking Domestic Television Apparatus in the 1990s 6. Weather Porn and the Battle for Eyeballs: The Transition to Digital Broadcasting in the US and UK 7. Redefining the Home Screen: The Case of the Digital Video Recorder 8. Marketers Strike Back: Virtual Advertising 9. 'How God Watches Television': Early Responses to Digital TV 10. High Tech in a Falling Market: Interactivity and Advertising Form in Contemporary US TV 11. 'Too easy, too cheap, and too fast too control': Intellectual Property Battles in Digital TV Select Bibliography
The Role of Fire and a Nonnative Grass as Disturbances in Semi-Desert Grasslands

Disturbances are key processes that alter environmental conditions which have consequences for species interactions; therefore, disturbances are important to maintenance of biological diversity. Climate, fire, livestock grazing, introduction of nonnative species, and humans all influence semi-desert grasslands of the southwestern United States. In southeast Arizona, a nonnative perennial grass, Lehmann lovegrass (Eragrostis lehmanniana), was introduced in the 1930s in an effort to restore degraded rangelands. I quantified annual fluctuations of Lehmann lovegrass and the response of native plants along a gradient of dominance by this nonnative grass. Biomass and richness of native plants declined with increasing dominance by Lehmann lovegrass. Substantial increases in biomass by Lehmann lovegrass in response to above-average rainfall did not result in decreases in native plants. Fire is an important disturbance in semi-desert grasslands. Herbaceous plants are favored over trees and shrubs in areas with frequent fires, therefore fire maintains grassland physiognomy. Humans have manipulated natural fire regimes however, by altering their frequency, season, and spatial extent. I experimentally investigated the possibility of a positive feedback cycle in grasslands invaded by Lehmann lovegrass by assessing whether the presence of Lehmann lovegrass was enhanced by fire to the detriment of native plants. In the two years postfire, the proportion of Lehmann lovegrass on burned sites did not increased compared to unburned sites or to pre-fire conditions. I also detected no changes in species richness,
Comparing effectiveness of Metoclopramide alone versus its combination with Dexamethasone for prevention of postoperative nausea and vomiting after thyroidectomy at Menelik II Hospital, Addis Ababa, Ethiopia: a prospective cohort study

Background Postoperative nausea and vomiting (PONV) is a common post- operative unpleasant experience and also common following thyroidectomy that may cause for hematoma and post-operative airway obstruction. Several agents have been tried to reduce severity and incidence PONV.This study intended to compare effectiveness of Metoclopramide alone and its combination with Dexamethasone for prevention of PONV after thyroidectomy at Menelik II Hospital.Methods Prospective cohort study was conducted on 76 American Society of Anesthesiologist (ASA) class I and II, adult patients undergone thyroidectomy. A systematic random sampling was applied to identify sample population through skip interval till required sample size was achieved. Study participants were grouped as Group = M (Metoclopramide alone) and Group = MD (Metoclopramide plus Dexamethasone). Following study participant received either 10 mg Metoclopramide or 5mg Metoclopramide plus 4mg Dexamethasone, PONV was recorded at 6, 12 and 24 hours post operatively. Continuous variables were expressed as mean ± SD or median-IQR as appropriate. Analysis was done by independent two sample t test, Manny Whitney U test and χ2 or fisher exact test. P-Value <0.05 was considered as statistically significant.Results The overall incidence of PONV with in the first 24 hours was significantly higher in Group M as compared to Group MD, 24(63.15%) versus 9 (23.68%) respectively with a P-value of < . 01. Although difference was insignificant, severity of nausea at 6th, 12th and 24th was still higher in Group M. From side effects, Sedation was significantly lower in Group MD 6 (15.79%) versus 15 (39.47%) with a P-value of <. 05. Despite difference was insignificant headache was found higher in Group M 10 (26.31) vs. 6 (10.52) respectively.Conclusions 5mg Metoclopramide combined with 4mg Dexamethasone has significant effects for prophylaxis of post-operative nausea and vomiting after thyroidectomy. Some side effects of drugs were also significantly reduced in combination group.
Correlating genomic copy number alterations with clinicopathologic findings in a case series of hepatocellular carcinoma

Background: Oligonucleotide array comparative genomic hybridization (aCGH) analysis has been used for detecting somatic copy number alterations (CNAs) in various types of tumors. This study aimed to assess the clinical utility of aCGH for a case series of hepatocellular carcinoma (HCC) and to evaluate the correlation between CNAs and clinicopathologic findings.Methods: Survival outcomes from this case series were analyzed based on Barcelona-Clinic Liver Cancer Stage (BCLC), Edmondson-Steiner grade (E-S), and recurrence status. aCGH was performed on 75 HCC cases with paired DNA samples from tumor and adjacent nontumor tissues. Correlation of CNAs with clinicopathologic findings was analyzed by Wilcoxon rank test and clustering vs. K means.Results: The survival outcomes indicated that BCLC stages and recurrence status could be predictors and E-S grades could be a modifier for HCC. The most common CNAs involved gains of 1q and 8q and a loss of 16q (50%), losses of 4q and 17p and a gain of 5p (40%), and losses of 8p and 13q (30%). Analyses of genomic profiles and clusters identified that losses of 4q13.2q35. 2 and 10q22.3q26. 13 seen in cases of stage A, grade III and nonrecurrence were likely correlated with good survival, while loss of 1p36.31p22. 1 and gains of 2q11.2q21. 2 and 20p13p11.1 seen in cases of stage C, grade III and recurrence were possibly correlated with worst prognosis. Conclusions: These results indicated that aCGH analysis could be used to detect recurrent CNAs and involved key genes and pathways in patients with HCC. Further analysis on a large case series to validate the correlation of CNAs with clinicopathologic findings of HCC could provide information to interpret CNAs and predict prognosis.
Growth Performance, Meat Quality, Meat Oxidation and Intestinal Bacterial Contents of Broilers Fed with Garcinia mangostana Peel Extract

Background: Extracts of mangosteen (Garcinia mangostana) peels possess various biological activities such as antioxidants and anti-bacteria. The aim of this study was to investigate the effects of mangosteen peel extract (MPE) on growth performance, meat quality, oxidation of meat and bacterial contents in the small intestine of broilers. Methods: The 192, 7-day-old, chicks were allocated to 4 treatments with 3 replicates per treatment, each replicate containing 16 chicks. Birds were fed diets supplemented with 0, 0.2, 0.4 or 0.8% of MPE for a period of 5 weeks ad libitum. Growth performance was evaluated weekly. At 42 days old, the birds were slaughtered and the breast muscles were sampled from 4 birds per replicate for determining meat quality and oxidation. To determine bacterial quantities, the residue of feed in the small intestine (ilium and ceca) was sampled from one bird per replicate. Result: The results revealed that MPE had no significant effect on growth performance and intestinal bacterial contents. However, it was found that 0.4 to 0.8% of MPE could improve the meat quality by decreasing drip loss and total water loss in muscles. Moreover, 0.8% MPE group tended to be lower in lipid oxidation. This suggests that 0.8% MPE might protect the broiler breast meat against oxidation.
Simulation of unsteady rotational flow over propfan configuration

During the past decade, aircraft engine manufacturers and scientists at NASA have worked on extending the high propulsive efficiency of a classical propeller to higher cruise Mach numbers. The resulting configurations use highly swept twisted and very thin blades to delay the drag divergence Mach number. Unfortunately, these blades are also susceptible to aeroelastic instabilities. This was observed for some advanced propeller configurations in wind tunnel tests at NASA Lewis Research Center, where the blades fluttered at cruise speeds. To address this problem and to understand the flow phenomena and the solid fluid interaction involved, a research effort was initiated at Georgia Institute of Technology in 1986, under the support of the Structural Dynamics Branch of the NASA Lewis Research Center. The objectives of this study are: (1) the development of solution procedures and computer codes capable of predicting the aeroelastic characteristics of modern single and counter-rotation propellers; and (2) the use of these solution procedures to understand physical phenomena such as stall flutter, transonic flutter, and divergence.
Flexural behavior of reinforced lightweight aggregate concrete beams

The research work reported in this paper deals with the flexural response of reinforced lightweight aggregate concrete (LWAC) beams. It consists of testing a total of 11 prototype beams designed to cover a wide range of parameters and address the major design issues, like cracking and crack width, stiffness and deflection and, strength and ductility. The results of these tests, presented and discussed in relation to the use of conventional normal weight concrete (NWC) and a major structural code ACI 318, indicate that the overall response of the LWAC beams used in this study with a density of 1850 kg/m3 closely resembles that of NWC beams and that the major structural code that contain provisions for the use of LWAC give reasonable predictions. The findings of this study should therefore serve as an encouragement for the regional building authorities to consider the use of LWAC to reap its potential benefits.
Effect of soil movement profiles on vertically loaded single pile

The behavior of a free head pile in sand under a combined lateral soil movement and vertical load was investigated using a newly developed experimental apparatus. Four instrumented pile tests are presented to compare the effect of soil movement profiles of an arc and rectangular shape on the response of the pile. It was found that (1) effect of soil movement profiles is significant; (2) Vertical load at the pile head leads to additional bending moment, and alteration of the pile-soil interaction mode. 1 INSTRUCTION Quite a few publications are available concerning response of piles subjected to vertical loads, and soil movements, respectively. Especially, in regard to that due to soil movement, experimental study has been conducted previously in light of centrifuge modeling
From problem-solving to sensemaking: A comparative meta-analysis of preparatory approaches for future learning

Against the backdrop of a growing body of research showing the effectiveness of problem-solving activities followed by instruction (PS-I), we report a meta-analysis of the effectiveness of three broad categories of preparatory activities on future learning from instruction: (a) problem-solving followed by instruction (PS-I), (b) scaffolded problem-solving followed by instruction (+PS-I), or (c) an alternative sensemaking activity followed by instruction (! PS-I)? We examined 118 experimental comparisons spanning 33 articles that compared PS-I with +PS-I and ! PS-I designs. Although scaffolding was descriptively associated with a small effect size, there was no significant difference relative to PS-I (Hedge’s g -0.08 [95% CI -0.20, 0.04]). Additionally, PS-I exhibited a non-significant moderate effect (Hedge’s g 0.22 [95% CI -0.06, 0.51]) compared to ! PS-I. Bayesian analyses strongly favored the null hypothesis for the comparison of PS-I with +PS-I (suggesting a 99% probability of the difference in effect between these designs being less than 0.2), while it suggested a 40.37% probability of at least a moderate effect favoring PS-I relative to ! PS-I. Further, the estimation of true effect sizes after accounting for the publication bias suggested moderate effect sizes in favor of PS-I, when considering both comparison conditions +PS-I (Hedge’s g 0.55) and ! PS-I (Hedge’s g 0.64).
Shakey the Robot

Abstract : From 1960 through 1972, the Artificial Intelligence Center at SRI conducted research on a mobile robot system nicknamed "Shakey. " Endowed with a limited ability to perceive and model its environment, Shakey could perform tasks that required planning, route finding, and the rearranging of simple objects. Although the Shakey project led to numerous advances in AI techniques, many of which were reported in the literature, much specific in formation that might be useful in current robotics research appears only in a series of relatively inaccessible SRI technical reports. Our purpose here, consequently, is to make this material more readily available by extracting and reprinting those sections of the reports that seem particularly interesting, relevant and important.
RATIO.

Mountrail County has 36 industrial properties out of a total of 993 commercial properties within the county that are being appraised by Thomas Y Pickett and Company (TY Pickett). These industrial properties are currently valued at $417,855,100 and comprise 49.3% of our total commercial values. It is very important to note that there are no sales for these industrial properties, hence adequate comparisons using the sales ratio study are not applicable.
Finding Best Possible Number of Clusters using K-Means Algorithm

Customers are assets for business. The companies are investing more for customer relationship management. Retaining customer for long time is a difficult process in today’s trend. On line shopping is also increasing day by day. People are more interested to visit popular web sites and they are spending very less time to choose their products. On line shops are paying more interest to analyze customer preferences, their needs, shopping behaviors through data mining technique. Proper classification is necessary for organizing such data. In this work, Customer with the same buying behavior is grouped based on the features age and salary. K-Means algorithm is applied to form clusters with different K values for original data and normalized data. The within sum of square (wss) is calculated for both the data for different cluster size. The minimum wss is considered to be better which is achieved in normalized data. The validity of cluster is evaluated by elbow, silhouette and gap statistic method to choose the optimal number of clusters. This work is implemented in R software.
Accounting for Model Uncertainty in Linear Mixed-Effects Models

Accounting for Model Uncertainty in Linear Mixed-Effects Models by Adam P. Sima Chair: Jessica M. Ketchum Standard statistical decision-making tools, such as inference, confidence intervals and forecasting, are contingent on the assumption that the statistical model used in the analysis is the true model. In linear mixed-effect models, ignoring model uncertainty results in an underestimation of the residual variance, contributing to hypothesis tests that demonstrate larger than nominal Type-I errors and confidence intervals with smaller than nominal coverage probabilities. A novel utilization of the generalized degrees of freedom developed by Zhang et al. (2012) is used to adjust the estimate of the residual variance for model uncertainty. Additionally, the general global linear approximation is extended to linear mixed-effect models to adjust the standard errors of the parameter estimates for model uncertainty. Both of these methods use a perturbation method for estimation, where random noise is added to the response variable and, conditional on the observed responses, the corresponding estimate is calculated. A simulation study demonstrates that when the proposed methodologies are utilized, both the variance and standard errors are inflated for model uncertainty. However, when a data-driven strategy is employed, the proposed methodologies show limited usefulness. These methods are evaluated with a trial assessing the performance of
Automatic Classification of Clinical Cases Using Deep Learning Techniques

The automatic assignation of disease codes is a complex problem that has been addressed many times throughout decades. In particular, the categorization of ICD (International Classification of Diseases) codes, which it's a compendium of symptoms, diseases, procedures and injuries. This activity is done by manually analyzing clinical cases or discharge summaries and its use has spread to areas like billing, administration or refund. Leading to associated costs close to $417 billion dollars for United States on 2012. Therefore in this investigation we propose Deep Learning models aiming to help in the task of code assignment. For this, 6 models are proposed, including architectures of Convulutional and Recurrent Neuronal Networks; both focused on NLP (Natural Language Processing) extracting features through aWord Embeddings approach. The results were obtained from the top 10, 20, 50 and 100 most frequent diseases; getting an Average Precision of 79,86% for the top 10 with an AUC of 91,37% which outperforms other methods used previously in this task.
The relationship between power output in different squats and sprint performance in young male soccer players

Background: Research has displayed a strong relationship between lower body strength and power, both in eccentric-concentric and concentric only exercises, in male soccer players. However the relationship between different types of squats and sprint performance has not been studied thoroughly in young male soccer players. Aim: The aim of the study was to investigate the relationship between sprint performance and power output in different squat variations in young male soccer players. Methods: Eleven young male soccer players, 17-19 years old, were tested in 1 repetition maximum (1RM) squat (S), 1RM concentric squat (CS) and in 5m, 10m, 15m and 30m sprint performance. Power testing in S and CS were performed at 30%, 50% and 70% of 1RM and registered as absolute power (W) and as power relative to body weight (W/kg). Results of the power output in S and CS were correlated with sprint performances. Correlations of rs ≥0.6 were considered to indicate a strong relationship. Results: There were strong correlations (rs = -0.61 to -0.68) between CS power output at 50% of 1RM, relative to body weight (W/kg), and all the sprint distances. S power output at 50% of 1RM, relative to body weight (W/kg), showed strong correlations (rs = -0.64 to -0.67) to 5m, 10m and 15m sprint. The only absolute power output (W) value to strongly correlate (rs = -0.62) with sprint performance was S at 50% of 1RM and 5m sprint. Conclusion: Both S and CS performance showed strong correlations with sprint start performance in young male soccer players. In conflict with previous research, this study showed a stronger correlation between CS and 30m sprint performance than S did. The results support previous findings that strength and power divided by body weight are stronger associated with sprint performance than absolute measures are. Both S and CS should be performed in the general strength training program to improve maximal strength and power, and thereby enhance soccer performance.
Threat perception while viewing single intruder conflicts on a cockpit display of traffic information

Subjective estimates of the threat posed by a single intruder aircraft were determined by showing pilots photographs of a cockpit display of traffic information. The time the intruder was away from the point of minimum separation was found to be the major determinant of the perception of threat. When asked to choose a maneuver to reduce the conflict, pilots selected maneuvers with a bias toward those that would have kept the intruders in sight had they been visible out the cockpit window.