Miracle-dz/UniFAR-FTUs huggingface dataset:
Hyaluronic Acid and Galacto-Xyloglucan Eyedrop Efficacy in Young-Adult Oral Contraceptive Users of Childbearing Age

To assess the efficacy of 0.4% hyaluronic acid and 0.2% galacto-xyloglucan for the subjective symptoms of dry eye disease and tear film invasive and noninvasive signs in 34 young-adult oral contraceptive users of childbearing age, a prospective, longitudinal, single-blind, clinical study was performed in a population of childbearing-age oral-contraceptive consumers. Subjective dry eye disease questionnaires, and invasive and noninvasive tear film assessments were reported before and after six weeks of hyaluronic acid with galacto-xyloglucan (HA-GX) treatment versus hyaluronic acid alone (HA). HA-GX treatment resulted in a greater decrease in the ocular surface disease index (17.01 ± 11.36 score points, p < 0.01) than the HA variation (11.61 ± 11.18 score points, p < 0.01). The standard patient evaluation of eye dryness also decreased more in the HA-GX group (4.06 ± 5.50 score points, p < 0.01) than in the HA alone group (0.70 ± 3.16, p = 0.21). Regarding noninvasive break-up time (NIBUT), the HA-GX group’s first NIBUT achieved an increase of 1.75 ± 1.16 s, p < 0.01, while the HA-alone group increased by only 0.54 ± 1.01 s, p < 0.01. The HA-GX group’s mean NIBUT reported an increase of 3.72 ± 5.69 s, p < 0.01; however, the HA-alone group achieved 2.19 ± 5.26 s, p = 0.05. Hyaluronic acid in combination with galacto-xyloglucan significantly decreased subjective dry eye disease symptoms and increased first and mean NIBUT compared to hyaluronic acid alone. Galacto-xyloglucan added efficacy in young-adult childbearing-age oral contraceptive users.
Management model, leadership and autonomy in Portuguese and Spanish public schools: A comparative analysis

Abstract The organisation of K-18 schools and the management function are similar in Portugal and Spain, although, in recent years, Portugal has surpassed Spain’s educational results. Based on the last international reports, this article compares the educational systems of both countries considering some variables related to the management model: (i) the general organisation of education in these stages, (ii) the characteristics of the teaching profession, including the process of recruitment and selection of teachers and principals, and (iii) the level of school autonomy and the type of management and leadership. Findings corroborated the existence of structural proximity in the governance of schools within the framework of a management model that is both centralized and participatory. However, there are differences in the permanency of educational laws, the duration of compulsory education, the grouping of schools, and the requirements to be a teacher. We conclude that the policies undertaken by Portugal to improve education (such as the extension of compulsory schooling, legislative stability, or the rethinking of the internal organization of schools) are succeeding and can serve as an example for Spain. Both countries could help principals become leaders for learning and improve their autonomy to favour changes in education.
REFINEMENT OF INHIBITORY CIRCUITS DURING DEVELOPMENT OF THE MAMMALIAN AUDITORY BRAINSTEM

Establishing precise neuronal connections is crucial for normal brain function. In many parts of the brain, this is accomplished by refining initially diffuse neuronal connections during development. In contrast to our understanding of the mechanisms by which excitatory connections are refined, the refinement of inhibitory circuits is poorly understood. In this thesis, I investigated the refinement of inhibitory connections in the lateral superior olive (LSO), a mammalian auditory brainstem nucleus involved in sound localization. The glycinergic, and during development also GABAergic, projection from the medial nucleus of the trapezoid body (MNTB) to the LSO is tonotopically organized with a single-cell-level precision in adults. I asked whether and by what mechanisms the precise organization emerges during development.I found that the refinement of this inhibitory pathway is achieved by a large degree of functional elimination of exuberant inputs and strengthening of maintained inputs. Elimination of inputs occurred in a frequency-specific manner, resulting in a sharper inhibitory topography. The topographic refinement occurred while the MNTB inputs act excitatory, raising the possibility that depolarizing action of GABA and glycine is a mechanism underlying the rearrangement of inhibitory synaptic connections. In parallel with the elimination, synaptic responses elicited by the maintained MNTB inputs increased over 10-fold. This was due to a moderate increase in quantal size and a large increase in the number of release sites formed by each MNTB fiber. I further investigated whether olivocochlear efferent neurons that project from the brainstem back to the cochlea play a role in the topographic sharpening. I found that the refinement of the MNTB-LSO pathway is impaired in animals with compromised efferent projections. In both efferent-lesioned rats and mice lacking the ? 9 nicotinic acetylcholine receptor subunit, LSO neurons received a greater number of weak MNTB inputs than in control animals. These results indicate that normal olivocochlear efferent projections are necessary for the refinement of the MNTB-LSO pathway. I discuss the possibility that the effect of efferent manipulation could be due to altered levels or temporal patterns of spontaneous activity before hearing onset.
Integrated Analysis and Identification of Critical RNA-Binding Proteins in Bladder Cancer

Simple Summary The role of RNA-binding proteins (RBPs) in bladder cancer (BC) remains unclear. Therefore, we analyzed the clinical information and RNA sequencing data from patients with BC and identified RBPs that may be promising predictors of BC. Abstract RBPs in the development and progression of BC remains unclear. Here, we elucidated the role of RBPs in predicting the survival of patients with BC. Clinical information and RNA sequencing data of the training and validation cohorts were downloaded from the Cancer Genome Atlas and Gene Expression Omnibus databases, respectively. Survival-related differentially expressed RBPs were identified using Cox regression analyses. A total of 113 upregulated and 54 downregulated RBPs were observed, with six showing prognostic values (AHNAK, MAP1B, LAMA2, P4HB, FASN, and GSDMB). In both the GSE32548 and GSE31684 datasets, patients with low-risk scores in survival-related six RBPs-based prognostic model showed longer overall survival than those with high-risk scores. AHNAK, MAP1B, P4HB, and FASN expression were significantly upregulated in both BC tissues and cell lines. BC tissues from high-risk group showed higher proportions of naive CD4+ T cells, M0 and M2 macrophages, and neutrophils and lower proportions of plasma cells, CD8+ T cells, and T-cell follicular helper compared to low-risk group. AHNAK knockdown significantly inhibited the proliferation, invasion, and migration of BC cells in vitro and inhibited the growth of subcutaneous tumors in vivo. We thus developed and functionally validated a novel six RBPs-based prognostic model for BC.
A robust facemask forgery detection system in video

An in-depth fake video uses an Artificial Intelligent (AI), AI programming, and a Personal computer (PC) mix to create a deep fake video of the action. Deep-faking can also be used to represent images and sounds. We provide insights into our reviews in this document. We're showing our dataset to start. At this point, we present the subtleties and reproductively of exploratory settings to evaluate the discovered effects finally. It is no surprise to find deep fake videos, which only monitor a tiny section of the video (e.g., the target face appears quickly on the video; hence the time is limited). We remove our system's fixed duration's persistent effects as each video contributes to the preparation, approval, and testing sections to reflect this. The edge groups are isolated from each video successively (without outline skips). The entire pipeline is ready to be finished when the approval stage is ten years old. Convolutional Neural Network (CNN) was the best and most reliable of the classification systems. Fake videos typically use low-quality pictures to mask faults or insist that the general public regard camera defects as unexplainable phenomena. 'This is a common trope with Unidentified Flying Object (UFO) videos: ghostly orbs are lenses; snakes are compression artifacts on one's face. In this study, we have implemented a sophisticated, knowledgeable method to recognize false images. Our test results using various monitored videos have shown that we can reliably predict whether videos are monitored through with simple co-evolutionary Long Short-Term Memory (LSTM) structure.
Realistic Mathematic Education-Based Student Worksheet to Improve Students' Mathematical Reasoning on Circle Material

Mathematical reasoning is a critical feature emphasized in the objective of mathematics education since it may be utilized to solve mathematical problems and other difficulties. This study aims to provide student worksheets based on Realistic Mathematics Education (RME) on circle material that are valid, practical, and useful in increasing students' mathematical reasoning abilities. This research used a 4-D development model. Validation sheets, practicality questionnaires, and test questions were employed as research tools. As a result of this research, the RME-based student worksheet on circle material is declared valid in content/material with an average of 4.05 and constructively valid with an average of 3.85. The practical findings show a value of 80.77% in the practical category. The effectiveness test revealed an N-Gain value of 0.57 with a fairly effective category. It may be concluded that the RME-based student worksheet developed is feasible, practical, and effective. As a result, the RME-based student worksheet can be used in learning to improve students' mathematical thinking abilities.
Bound on the number of functions that can be distinguished with k quantum queries

Suppose an oracle is known to hold one of a given set of D two-valued functions. To successfully identify which function the oracle holds with k classical queries, it must be the case that D is at most ${2}^{k}. $ In this paper we derive a bound for how many functions can be distinguished with k quantum queries.
Multi-Access Channel Based on Quantum Detection in Wireless Optical Communication

In this paper, we propose a novel multi-user access in wireless optical communication based on the quantum detection of the coherent state. In this case, the coherent states are used as the signal carrier and a technique of quantum detection is applied to distinguish between signals from different users. To accomplish this task, two main quantum measurement methods are introduced; one is minimum error discrimination (MED), and the other is unambiguous state discrimination (USD). The theoretical derivation implies that the two methods can both distinguish between the signals from different users efficiently when the average photon number is large enough. Typically, the numerical result shows that in the two-user case, the channel capacity will approach the theoretical maximum limit when the average photon number is greater than 2.5 for MED and 5 for USD in the absence of noise. The MED gains more channel capacity than the USD at the same average photon number. However, the USD wins the error-correction scene with its free-error capability. Furthermore, the detection error probability and channel capacity for the USD with the thermal noise are examined. The result shows that increasing the signal average photon number can continue the USD’s advantage of error-free detection even if in the presence of thermal noise. In addition, compared with non-orthogonal multiple access (NOMA), the bit error rate (BER) against signal-to-noise rate (SNR) performance of USD has been improved.
Clinical profile of the patients at Siddha Covid Care Centre, Theni, Tamil Nadu, India – A cross-sectional study

Introduction: The Indian Government issued various guidelines to the state government wherein introduced plan for setting up COVID care centres (CCC) to isolate and monitor asymptomatic and mild COVID-19 patients. The Government of Tamil Nadu, apart from CCC used the strength of traditional Siddha medicine, one of the Indian systems of medicine, by opening Siddha Covid Care Centres (SCCC) at various facilities like community hall, housing board homes, school and college hostels, across the state in 37 districts. Methods: As a cross-sectional study, we evaluated the clinical profile of the laboratory confirmed COVID-19 patient admitted in SCCC, Theni district, Tamil Nadu, India, which was opened on 8 May 2021. Results: During this month, 585 COVID-19 positive patients were admitted. Among them 60.9% were males, 39.1% were females. 40% of the admitted patients were in the age the group 31–50 years. 13% of the patient had at least one of the co-morbid condition and 80% were symptomatic with fever 40% and cough 36% as more common. Discussion: Patients were treated with the Siddha system of medicine adhering to the guidelines and were discharged after 10 days treatment. Nearly 4% who required further medical treatment observing their clinical condition and SpO2 levels were referred to the nearby medical college hospital. Conclusion: This study illustrated that SCCC offered appropriate clinical triaging and daily monitoring and hence it was considered as safe alternative to medical institutions during the pandemic.
The Effect of Sweet-tasting Foods Addiction on Appetite-related Hormones among Obese Adolescents

Background: Food ingestion and energy spending are organized through a complicated neu-rological system that involves both hypothalamic centers and peripheral satiety regulation (gastrointestinal and pancreatic hormones). Objectives: To assess the eﬀects of sugar addiction on appetite-related hormones and metabolic hormones. Materials and methods: The study was done in two main hospitals in Anbar governorate, Iraq from April 2020 to November 2020. Concentration of fasting blood glucose (FBG), insulin, hormone insulin resistance (HOMA-IR), leptin, ghrelin, lipid proﬁle, TSH, T3, and T4 were measured in the 54 obese adolescents and were compared with 54 normal-weight adolescents. Results: There was a signiﬁcant increase in the concentrations of FBG, insulin, HOMA-IR, leptin, total cholesterol (TC), triacylglycerol (TAG), low-density lipoprotein cholesterol (LDL-C), and TSH in obese adolescents as compared to normal-weight adolescents (P-value < 0.05). While there was a signiﬁcant (P < 0.05) decreased in the concentrations of ghrelin, high-density lipoprotein cholesterol (HDL-C), T3, and T4 in obese adolescents compared with normal-weight adolescents. The results also showed that there is a signiﬁcant positive correlation between the concentration of leptin and each of BMI, FBG, insulin, and HOMA-IR, while there was a signiﬁcant negative association between leptin level with HDL-C and ghrelin. Conclusion: overeating and thus leads to obesity.
Correlation effects in Yb + and implications for parity violation

Calculation of the energies, magnetic dipole hyperfine structure constants, E1 transition amplitudes between the low-lying states, and nuclear spin-dependent parity-nonconserving amplitudes for the ^2S_{1/2} - ^2D_{3/2,5/2} transitions in ^{171}Yb^+ ion is performed using two different approaches. First, we carried out many-body perturbation theory calculation considering Yb^+ as a monovalent system. Additional all-order calculations are carried out for selected properties. Second, we carried out configuration interaction calculation considering Yb as a 15-electron system and compared the results obtained by two methods. The accuracy of different methods is evaluated. We find that the monovalent description is inadequate for evaluation of some atomic properties due to significant mixing of the one-particle and the hole-two-particle configurations. Performing the calculation by such different approaches allowed us to establish the importance of various correlation effects for Yb^+ atomic properties for future improvement of theoretical precision in this complicated system.
Photobiomodulation Treatment in Chemotherapy-Induced Oral Mucositis in Young Haematological Patients—A Pilot Study

Background and Objectives: One of the most debilitating side effects of chemotherapy is oral mucositis (OM). Photobiomodulation (PBM) demonstrates high efficacy in the management of OM. The aim of the study was to investigate the incidence of oral mucositis and evaluation of the effectiveness of PBM therapy. Materials and Methods: A total of 23 children diagnosed with leukaemia or lymphoma affected by chemotherapy-induced OM were enrolled in the study. OM grade was assessed with the World Health Organization (WHO) scale. Patients completed an approved questionnaire, and blood cell counts were read every 2 days. OM lesions were treated with class IV laser therapy with a frequency of every 48 h and density of 2, 4, 8, 16 or 30 J/cm2. The level of pain was measured with VAS scale. Results: The 23 patients developed a total of 41 OM episodes with a mean duration of 7.61 days ± 4.70. Laser therapy showed a great reduction regarding pain and a better function of patients even with neutropenia. Conclusions: Oral mucositis represents a significant burden to children. PBM brings positive aspects for patients; however, the optimal treatment parameters require further study.
Efficacy and Safety of JAK Inhibitors for Rheumatoid Arthritis: A Meta-Analysis

Background: More and more trials have been conducted. We aimed to assess the efficacy and safety of different JAKinibs in RA. Methods: A systematic search of randomized controlled trials (RCTs) with JAKinib treatment in RA published in the Medline, Embase, and Cochrane databases up to May 2021 was performed. Results: 37 trials involving 15,174 patients were identified. Pooled analysis revealed that JAKinibs were associated with significant therapeutic improvement in RA patients as determined by ACR20 (RR = 2.03, 95% CI: 1.85 to 2.28) and HAQ-DI (MD = −0.31, 95% CI: −0.33 to −0.28) over placebo. Compared to placebo, JAKinib treatment was also associated with more adverse events (RR = 1.10, p < 0.001; RR = 1.29, p < 0.001; RR = 1.59, p = 0.02). Baricitinib and upadacitinib were related to more frequent adverse events (RR = 1.10; 95% CI: 1.01, 1.21; RR = 1.19; 95% CI: 1.11, 1.28) and infection (RR = 1.22; 95% CI: 1.09, 1.37; RR = 1.38; 95% CI: 1.22, 1.56), whereas only baricitinib was associated with more herpes zoster (RR = 3.15; 95% CI: 1.19, 8.33). Conclusions: JAKinibs were superior to placebo for improving signs, symptoms, and health-related quality of life in RA patients at short term, whereas the overall risk of adverse events and infections were greater with baricitinib and upadacitinib, and a higher risk of herpes zoster was only associated with baricitinib. More trials are needed to investigate the long-term safety.
A quantitative assessment of the risk of falls in rheumatoid arthritis patients and determination of the risk factors

Objectives The aim of this study was to compare the risk of falling in patients with rheumatoid arthritis (RA) to the healthy individuals and to identify the factors affecting the risk of falls. Patients and methods Between December 2015 and August 2016, a total of 100 consecutive patients with RA (16 males, 84 females; mean age: 49.5±11.1 years; range, 21 to 65 years) and 50 healthy controls (11 males, 39 females; mean age: 34.3±12.7 years; range, 19 to 63 years) were included in this prospective study. The fall risk was evaluated using the Tetrax Portable Balance System. The Health Assessment Questionnaire Disability Index (HAQ-DI), RA disease activity (Disease Activity Score 28 [DAS28], Clinical Disease Activity Index [CDAI], and Simple Disease Activity Index [SDAI]), and Falls Efficacy Scale International (FES-I) were applied to all participants. Results The fall risk scores and the FES-I scores were significantly higher in the patients with RA than the control group (p<0.001, p<0.001). A positive significant correlation was found between the Tetrax values of the patients and age, and the scores of the HAQ-DI, FES, DAS28, DAS28-C-reactive protein, CDAI and SDAI. Conclusion Our study results showed higher fall risk scores in patients with RA than healthy individuals an objective computerized technique, and this higher fall risk appeared to be affected by older age, disease activity, and disability.
The Use of Rosetta Stone in Improving Speaking Skill

The purpose of this study is to determine the efficacy of using technology-based teaching media to improve the speaking skills of STP Mataram Hospitality Study Program students. Several media that use computers and the internet will be used in this study to teach speaking. Rosetta Stone is used as learning media for students' speaking learning. In this study, 30 students served as the experimental group, while 30 other students served as the control group. According to the findings of this study, the value of the t-test > t table (3.462> 2.676) indicates a significant difference in English speaking skills when using technology-based learning media. Finally, the use of technology-based learning media is effective in improving students' speaking abilities.
Associations between the Nutrient Profiling System Underlying the Nutri-Score Nutrition Label and Biomarkers of Chronic Low-Grade Inflammation: A Cross-Sectional Analysis of a Middle- to Older-Aged Population

Low-grade systemic inflammation is associated with a range of conditions. Diet may modulate inflammation and public health strategies are needed to guide consumers’ dietary choices and help prevent diet-related disease. The Food Standards Agency nutrient profiling system (FSAm-NPS) constitutes the basis of the five-colour front-of-pack Nutri-Score labelling system. No study to date has examined FSAm-NPS dietary index associations with biomarkers of inflammation. Therefore, our objective was to test relationships between the FSAm-NPS and a range of inflammatory biomarkers in a cross-sectional sample of 2006 men and women aged 46–73 years. Individual participant FSAm-NPS scores were derived from food frequency questionnaires. Pro-inflammatory cytokine, adipocytokine, acute-phase response protein, coagulation factor and white blood cell count concentrations were determined. Correlation and linear regression analyses were used to examine FSAm-NPS relationships with biomarker levels. In crude and adjusted analyses, higher FSAm-NPS scores, reflecting poorer nutritional quality, were consistently and positively associated with biomarkers. In fully adjusted models, significant associations with concentrations of complement component 3, c-reactive protein, interleukin 6, tumour necrosis factor alpha, resistin, white blood cell count, neutrophils, eosinophils and the neutrophil-to-lymphocyte ratio persisted. These results suggest that dietary quality, determined by Nutri-Score rating, is associated with inflammatory biomarkers related to health.
Low-level laser therapy versus extracorporeal shock wave therapy in calcaneal spur

In this study, patients with calcaneal spur were randomized into low-level laser therapy (LLLT) and extracorporeal shock wave therapy (ESWT) groups, and both groups received cold-pack and plantar fascia stretching exercises in addition to the investigated modalities. Although the authors have explained the application methods of LLLT and ESWT in detail, there is lack of information about the application of cold-pack and stretching of the plantar fascia and calf muscles. The readers have no idea why cold-pack was preferred instead of a hot agent before stretching, although acute inflammation was an exclusion criterion for the study; where the cold-pack was applied (on the plantar region of the foot, on calf muscles or both, etc.? ); and what was the detailed protocol for stretching exercises (types of, positions and durations/repetitions for stretching, etc.).