Miracle-dz/UniFAR-FTUs huggingface dataset:
Web-Based Intervention Using Behavioral Activation and Physical Activity Adults Depression Study): Pilot

Background: Physical activity is a potentially effective treatment for depression and depressive relapse. However, promoting physical activity in people with depression is challenging. Interventions informed by theory and evidence are therefore needed to support people with depression to become more physically active. eMotion is a Web-based intervention combining behavioral activation and physical activity promotion for people in the community with symptoms of depression. Objective: The objectives were to assess the feasibility and acceptability of delivering eMotion to people in the community with symptoms of depression and to explore outcomes. Methods: Participants with elevated depressive symptoms were recruited from the community through various methods (eg, social media) and randomized to eMotion or a waiting list control group for 8 weeks. eMotion is an administratively supported weekly modular program that helps people use key behavior change techniques (eg, graded tasks, action planning, and self-monitoring) to re-engage in routine, pleasurable, and necessary activities, with a focus on physical activities. Feasibility data were collected that included the following: recruitment and trial retention rates; fidelity of intervention delivery, receipt, and enactment; and acceptability of the intervention and data collection procedures. Data were collected for the primary (depression) and secondary outcomes (eg, intervention group than for the control group at 2 months postrandomization (adjusted mean difference −3.6, 95% CI −6.1 to −1.1). Conclusions: It was feasible to deliver eMotion in UK communities to inactive populations. eMotion has the potential to be effective and is ready for testing in a full-scale trial. Further work is needed to improve engagement with both the intervention and data collection procedures.
Discussion Papers in Economics Dynamics of Output Growth, Consumption and Physical Capital in Two-Sector Models of Endogenous Growth Coordination and Equilibrium Selection in Mean Defined Supermodular Games Under Payoff Monotonic Selection Dynamics

This paper introduces the class of mean de(cid:12)ned supermodular games. The characteristic feature of these games is that, given an order on the strategy sets of the players, the payo(cid:11) to each player depends on his own strategy and the average of the population play. We characterise the set of the Nash equilibria and analyse their dynamic properties under payo(cid:11) monotonic selection dynamics. Weak Nash equilibria, both in pure and mixed strategies, are unstable. The only asymptotically stable equilibria of the game are symmetric strict equilibria where each player uses the same strategy. We show that the strategies that do not survive the process of iterated deletion of strictly dominated strategies vanish in the long run. As a corollary to this latter result, we show that if the game is dominance solvable then the dynamics converges from any initial interior state.
Mechanical forces and TGF β 1 reduce podocyte adhesion through α 3 β 1 integrin downregulation

Background. Podocyturia is a marker of diabetic nephropathy, a possible determinant of its progression and a pow-erful risk factor for cardiovascular disease. A reduction in podocyte adhesion to the glomerular basement membrane (GBM) via downregulation of α 3 β 1 integrin expression, the main podocyte anchoring dimer to the GBM, may represent one of the mechanisms of podocyturia in glomerular dis-ease. This study investigated the role of mechanical forces and transforming growth factor beta1 (TGF β 1) in podocyte adhesion and integrin expression. Methods. Conditionally immortalized murine podocytes were exposed to mechanical and/or for of 1 1, may represent a parallel important determinant of the podocyte loss from the instruc- tions. chemilumi-nescence(AmershamLifeScience,Buckinghamshire,UK)andquantifiedusingImageJ(NIH,Bethesda,MD,USA). Equalproteinloadingwasver-ifiedwithPonceau-SstainingandbyanalysisofthehousekeepingproteinGAPDH(1/200,Chemicon,Hampshire,UK). Abstract Background. Increased transforming growth factor beta-1 (TGF beta) expression in the kidney is central not only to the pathogenesis of tubulointerstitial fibrosis but also in repair following acute injury. Recent work suggests that pro-inflammatory cytokines may determine epithelial cell responses to TGF beta in the contexts of acute injury and chronic wounding. Methods. In this study, we examined the effects of interleukin-1 beta (IL-1) on proximal tubular cell (PTC) response to TGF beta. Results. IL-1 induced the rapid activation of NF- κ B in PTC. This was associated with inhibition of Smad2 and Smad3 signalling. NF- κ B activation by IL-1 was transient, with a change from p65/p50 heterodimer to p50/p50 ho-modimer formation by 24 h and a switch to enhanced Smad signalling response to TGF beta. This was associated with IL-6 generation and prevented by IL-6 receptor blockade. Conclusion. In summary, IL-1 has a biphasic effect on PTC TGF beta signalling, with early NF- κ B-mediated inhibition and delayed sensitization via an autocrine
C hironomus strenzkei F ittkau , 1968 is a junior synonym oF C. striatipennis k ieFFer , 1910

Two species of Chironomus with essentially identical adult wing patterns, C. strenzkei and C. striatipennis , have been reported from Brazil. Specimens were collected from the same region in the Manaus area some 50 years apart. Morphological, cytological and DNA Barcode comparisons all confirm that these two species are inseparable on any of the characteristics studied. Moreover, for the mitochondrial COI region investigated, the sequences are completely identical, and polytene chromosome banding patterns are shared between C. strenzkei and C. striatipennis populations from Japan. I therefore argue that the former species must be a junior synonym of C. striatipennis. As a result of the synonymy, C. striatipennis now becomes a new record for California and North America, and hence has a Holarctic distribution. The DNA sequence comparisons suggest that the Brazilian population may have derived from China, rather than Korea as suggested previously, and that the Californian population may not have been introduced from South America, but could equally likely have come from Asia.
Functional and Genetic Characterization of the Tap Efﬂux Pump in Mycobacterium bovis BCG

Efﬂux pumps extrude a wide variety of chemically unrelated compounds conferring multidrug resistance and participating in numerous physiological processes. Mycobacterium tuberculosis possesses many efﬂux pumps, and their roles in drug resistance and physiology are actively investigated. In this work we found that tap mutant cells showed changes in morphology and a progressive loss of viability upon subcultivation in liquid medium. Transcriptome analysis in Mycobacterium bovis BCG revealed that disruption of the Rv1258c gene, encoding the Tap efﬂux pump, led to an extensive change in gene expression patterns during stationary phase, with no changes during exponential growth. In stationary phase, Tap inactivation triggered a general stress response and led to a general repression of genes involved in cell wall biosynthesis, in particular the formation of the peptidoglycan; this suggested the accumulation of an unknown Tap substrate that reaches toxic concentrations during stationary phase. We also found that both disruption and overexpression of tap altered susceptibility to many clinically approved antibiotics in M. bovis BCG. Acriﬂavine and tetracycline accumulation assays and carbonyl cyanide m -chlorophenylhydrazone (CCCP) potentia-tion experiments demonstrated that this phenotype was due to an active efﬂux were inoculated on a ﬁxed subinhibitory concentration of antibiotic using a Steer replicator. A conventional disc diffusion assay was used to test the redox compounds. Brieﬂy, an expo-nential-phase culture dilution containing 10 6 cells/ml was spread on Middlebrook 7H10 agar plates, and discs containing the redox com-poundswereplacedontothelawn.Visiblegrowthwasscoredafter21daysofincubation. Experimentswerecarriedoutintriplicateandrepeatedatleastthreetimes. incubated to allow stabilization of the ﬂuorescence of was the
Hydromorphological, hydraulic and ecological effects of restored wood: findings and reflections from an academic partnership approach

Large wood (re)introduction can deliver multiple benefits in river restoration, but there is a dearth of the detailed and longer‐term post‐project monitoring and evaluation required for improving best practice. We present findings from an academic partnership approach to post‐project evaluation, based on successive MSc research projects on restored large wood in the Loddon catchment, UK. Field and modelling data reveal: (i) key differences in large wood features between restored and natural reaches; (ii) increased hydraulic retention and changes to mesohabitats associated with large wood; (iii) differences in macroinvertebrate community composition around large wood but a lack of site‐level effects; (iv) interactions between macrophytes and large wood that may be specific to restored reaches; (v) a need for further field and modelling studies to inform the accurate representation of large wood in hydraulic models. Some key challenges in partnership working are identified to aid planning and effectiveness of future collaborations.
Nursing assessment of early complications of coma patients

Nursing assessment for coma patients on admission is the basic step for the care to be effective. Assessment must be done every 15 minute. Comatosed patients are completely dependent on nurses as their abilities and protective are impaired. Nurses are responsible for their basic life needs and to prevent complications associated with coma. Aim: This study aimed to assess early complications for coma patients. Research design: a descriptive research design was used in this study. Setting: This study was conducted in emergency Unit at Assuit University Hospital and intensive care unit. Tools of data collection: (I) Patient assessment sheet (II) Cardio vascular complications assessments sheet . (III) Respiratory complications assessment sheet. (IV)Gastrointestinal tract complications assessment sheet. (VI) Laboratory investigations sheet. Results: the results showed that (77.5%) of Patient had complications of coma. Conclusion this study showed that were complications associated with coma affect on all body systems and nursing assessment help to know and treat these complications. Recommendation: the study recommends conducting in large number of comatosed patients.
Artiﬁcial Neural Network and Adaptive Neuro-Fuzzy Interface System Modelling to Predict Thermal Performances of Thermoelectric Generator for Waste Heat Recovery

: The present study elaborates the suitability of the artiﬁcial neural network (ANN) and adaptive neuro-fuzzy interface system (ANFIS) to predict the thermal performances of the thermoelectric generator system for waste heat recovery. Six ANN models and seven ANFIS models are formulated by considering hot gas temperatures and voltage load conditions as the inputs to predict current, power, and thermal e ﬃ ciency of the thermoelectric generator system for waste heat recovery. The ANN model with the back-propagation algorithm, the Levenberg–Marquardt variant, Tan-Sigmoidal transfer function and 25 number of hidden neurons is found to be an optimum model to accurately predict current, power and thermal e ﬃ ciency. For current, power and thermal e ﬃ ciency, the ANFIS model with pi-5 or gauss-5-membership function is recommended as the optimum model when the prediction accuracy is important while the ANFIS model with gbell-3-membership function is suggested as the optimum model when the prediction cost plays a crucial role along with the prediction accuracy. The proposed optimal ANN and ANFIS models present higher prediction accuracy than the coupled numerical approach.
Numerical radius and distance to unitaries

Denote by w(A) the numerical radius of a bounded linear operator A acting on Hilbert space. Suppose that A is invertible and that w(A) ≤ 1+e and w(A) ≤ 1+e for some e ≥ 0. It is shown that inf{‖A−U‖ : U unitary} ≤ ce for some constant c > 0. This generalizes a result due to J.G. Stampfli, which is obtained for e = 0. An example is given showing that the exponent 1/4 is optimal. The more general case of the operator ρ-radius wρ(·) is discussed for 1 ≤ ρ ≤ 2.
Carbon Nanotubes (CNTs) in Asphalt Binder: Homogeneous Dispersion and Performance Enhancement

Conventional binders cannot meet the current performance requirements of asphaltic pavements due to increase in traffic volumes and loads. Nanomaterials, due to their exceptional mechanical properties, are gaining popularity as bitumen modifiers to enhance the performance properties of the asphaltic concrete. Carbon Nanotubes (CNTs) are one of the most widely used nanomaterials because of their strength properties, light weight, small size, and large surface area. CNT addition results in improved substrate characteristics as compared to other modifiers. Due to high length to diameter ratio, dispersion of CNTs in bitumen is a complex phenomenon. In this study, dispersion of CNTs in bitumen was carried out using both dry and wet mixing techniques, the latter was selected on the basis of homogeneity of the resultant asphalt mixture. Scanning Electron Microscopy (SEM) was used to check the dispersion of CNTs in binder while Fourier Transform Infrared Spectroscopy (FTIR) was carried out to ensure the removal of solvent used for wet mixing. Conventional bitumen tests (penetration, softening point, and ductility), dynamic shear rheometer tests, rolling bottle tests, and bitumen bond strength tests were employed to check the improvement in the rheological and adhesion properties of bitumen while wheel tracker test was used to check the improvement in resistance against permanent deformation of asphalt mixtures after addition of CNTs. Results show that CNTs improved the higher temperature performance and permanent deformation resistance in both binder and mixtures. Improvement in bitumen–aggregate adhesion properties and moisture resistance was also observed.
Lack of phosphatidylglycerol inhibits chlorophyll biosynthesis at multiple sites and 26 limits chlorophyllide reutilization in Synechocystis PCC 6803

of lipid phosphatidylglycerol inhibits chlorophyll biosynthesis and induces accumulation of an aberrant protein complex containing monomeric Photosystem Abstract The negatively charged lipid phosphatidylglycerol (PG) constitutes up to 10% of total lipids 47 in photosynthetic membranes and its deprivation in cyanobacteria is accompanied by 48 chlorophyll (Chl) depletion. Indeed, radioactive labeling of the PG depleted Δ pgsA mutant of 49 Synechocystis 6803, which is not able to synthesize PG, proved inhibition of Chl biosynthesis 50 due to restriction on the formation of 5-aminolevulinic acid and protochlorophyllide. 51 Although the mutant accumulated chlorophyllide, the last Chl precursor, we demonstrated that it originated from dephytylation of existing Chl and not from the block in the Chl biosynthesis. The lack of de novo produced Chl under PG depletion was accompanied by a significantly weakened biosynthesis of both monomeric and trimeric photosystem I (PSI) complexes, though the decrease in cellular content was manifested only for the trimeric form. However, our analysis of Δ pgsA mutant, which lacked trimeric PSI due to the absence of the 57 PsaL subunit, suggested that the virtually stability of monomeric PSI is a result of 58 disintegration of PSI trimers. Interestingly, the loss of trimeric PSI was accompanied by 59 accumulation of monomeric PSI associated with the newly synthesized CP43 subunit of 60 Photosystem II. We conclude that the absence of PG results in the inhibition of Chl 61 biosynthetic pathway, which impairs synthesis of PSI despite the accumulation of 62 chlorophyllide released from the degraded Chl-proteins. Based on the knowledge about the 63 role of PG in prokaryotes we hypothesize that the synthesis of Chl and PSI complexes are co- 64 located in a membrane microdomain requiring PG for integrity. open-reading ycf54 activity protoporphyrin monomethylester cyclase D1 protein biogenesis.
Male Linked Genomic Region Determines Sex in Dioecious Amaranthus palmeri

Abstract Dioecy, the separation of reproductive organs on different individuals, has evolved repeatedly in different plant families. Several evolutionary paths to dioecy have been suggested, but the mechanisms behind sex determination is not well understood. The diploid dioecious Amaranthus palmeri represents a well-suited model system to study sex determination in plants. Despite the agricultural importance of the species, the genetic control and evolutionary state of dioecy in A. palmeri is currently unknown. Early cytogenetic experiments did not identify heteromorphic chromosomes. Here, we used whole-genome sequencing of male and female pools from 2 independent populations to elucidate the genetic control of dioecy in A. palmeri. Read alignment to a close monoecious relative and allele frequency comparisons between male and female pools did not reveal significant sex-linked genes. Consequently, we employed an alignment-free k-mer comparison which enabled us to identify a large number of male-specific k-mers. We assembled male-specific contigs comprising a total of almost 2 Mb sequence, proposing a XY sex-determination system in the species. We were able to identify the potential Y chromosome in the A. palmeri draft genome sequence as 90% of our male-specific sequence aligned to a single scaffold. Based on our findings, we suggest an intermediate evolutionary state of dioecy with a young Y chromosome in A. palmeri. Our findings give insight into the evolution of sex chromosomes in plants and may help to develop sustainable strategies for weed management.
INFLUENCE OF USING ROCKET SEED ( Eruca sative ) OIL AND ONION SEED ON PRODUCTIVE AND PHYSIOLOGICAL PERFORMANCE OF GROWING RABBITS UNDER HOT CLIMATE CONDITION

: A completely random experiment was conducted to evaluate rocket and onion seed oils or their mixture under climate summer conditions on growth performance, carcass traits, rectal temperature, respiration rate, immunity (antibody titer against SRBC’S), blood biochemistry, digestibility coefficients, and economical efficiency of growing rabbits, from July to September, 2009 . The averages of daily ambient temperature, relative humidity and temperature humidity index (THl) inside the building were 30.27 ±0.68°C, 75.95±2.88% and 29.36, respectively. A total of 96 NZW rabbits, weaned at 6 weeks of age with an average initial body weight, 623.00 ± 3.09,g were randomly distributed to four experimental treatments (24 rabbits/ each) then divided into 3 replicates of eight rabbits each. Rabbits were fed the basal diet either unsupplemented (control) or supplemented with 1g rocket seed oil/Kg diet, or 1g onion seed oil/ Kg diet and their combination throughout the whole experimental period which lasted for 12 weeks. The experimental basal diet was isonitrogenous (CP=17 %) and isocaloric (2500 Kcal/Kg DE). Results obtained showed that percentages of total unsaturated fatty acids, especially polyunsaturated fatty acid (linoleic) in onion oil were higher than in rocket oil. The percentage of fatty acid Erucic was higher in rocket oil than those in onion oil . Under the high ambient temperatures final body weight and carcass traits of growing rabbits were significantly (P<0.05) increased and feed conversion values were improved with dietary supplementation with either rocket oil or onion oils or their mixtures compared with the control group. Dietary either rocket or onion oil and their mixture of growing rabbits ameliorated some of the adverse effects of heat stress on immune response, rectal temperature and respiration rate. Dietary supplementation, also improved (P≤0.05) antibody titer against SRBC’S as compared with the control. Serum total protein and albumin were significantly increased (P ≤ 0.05) while, serum total lipids, glucose, AST and ALT concentrations were significantly decreased (P ≤ 0.05) due to dietary rocket oil only or with onion oil as compared with the control group. Digestibility coefficients of CP and EE were significantly (P<0.05) affected by dietary addition, being the highest for rocket oil diet, followed by rocket +onion oils diet as compared with the control group. Rocket oil fed group recorded the highest (P<0.05) net return, best economical efficiency and performance index followed by those fed rocket oil plus onion oil and onion oil treatments as compared with the control group. In conclusion , supplementation of rocket and onion seed oils in growing rabbit diets enhanced growth performance carcass weight and digestibility coefficient of CP, EE and elevated the immunity as well as reduced rectal temperature and respiration rate when growing rabbits were subjected to heat stress.
Fractional charge effects in calculations of ground-state energy of hydrogen molecules by local density approximation

Density Functional Theory is a very successful computational approach to solve multi-electron systems. It simply treats electrons in atoms, molecules and crystals as electron density distribution, and sets up corresponding energy functionals. Many pioneers in this field such as Hohenberg, Kohn and Sham proposed ideas of using homogeneous electron gas systems to estimate the desire properties of the sample, which makes many-body systems much easier to solve. However, computational physicists and chemists have been struggling for the fundamental error of such an approximation method, which deals with the inaccuracy of calculating ground-state energy, band gap and ionization energy. It is known as the Delocalization Error. Delocalization error occurs in charge transfer process when the charge exchange is not integer charge. It lowers the energy calculated by typical approximation methods of Density Functional Theory to a great extent. Over the years, corrections and modifications of those approximate functionals have been made to eliminate the error, whereas the fundamentals of the error remain untold. Recent research has given insights on the size dependence of the problem, which opened a new direction of study on the delocalization error. In this paper, the main theory of density functional theory will be reviewed once, with additional notes to one of the approaches to construct functionals – Local Density Approximation. The fractional charge problem is then demonstrated by appropriate programming code and various system configurations to make analysis on possible geometric dependence appeared. Possibly further investigation of the problem could be taken, for example, extending the system to two-dimensional crystal structure.
Bone Tissue Engineering Using Human Cells: A Comprehensive Review on Recent Trends, Current Prospects, and Recommendations

The use of proper cells for bone tissue engineering remains a major challenge worldwide. Cells play a pivotal role in the repair and regeneration of the bone tissue in vitro and in vivo. Currently, a large number of differentiated (somatic) and undifferentiated (stem) cells have been used for bone reconstruction alone or in combination with different biomaterials and constructs (e.g., scaffolds). Although the results of the cell transplantation without any supporting or adjuvant material have been very effective with regard to bone healing. Recent advances in bone scaffolding are now becoming new players affecting the osteogenic potential of cells. In the present study, we have critically reviewed all the currently used cell sources for bone reconstruction and discussed the new horizons that are opening up in the context of cell-based bone tissue engineering strategies.