Miracle-dz/UniFAR-FTUs huggingface dataset:
Establishment of a reference interval for a novel viscoelastic coagulometer and comparison with thromboelastography in healthy cats.

BACKGROUND Viscoelastic analysis provides information on the dynamics and strength of clot formation as well as clot stability. A novel point-of-care viscoelastic test (Viscoelastic Coagulation Monitor Vet, VCM Vet) could be more cost-effective, simpler to use, and more portable than thromboelastography (TEG). OBJECTIVES The primary aim of this study was to establish a feline reference interval (RI) for the VCM Vet. A secondary aim was to compare VCM Vet analysis with TEG in healthy cats. METHODS Fifty-six healthy cats were enrolled in this study. Linear regression was completed to determine whether age and CBC parameters were associated with the VCM Vet parameters and if TEG parameters were correlated with VCM Vet data. Statistical significance was set at P < . 05. RESULTS Fifty-three VCM Vet tracings were used to determine RIs for healthy cats. The determined RIs were: clot time (CT) 104-438 seconds; clot formation time (CFT) 104.5-488 seconds; alpha angle (AA) 30.5°-70°; a10 13.8-32.7 VCM units; a20 19.2-40.1 VCM units; maximum clot formation (MCF) 22.5-44.8 VCM units; Lysis Index 30 (Li30) 92.9%-100.9%; and Lysis Index 45 (Li45) 92%-100%. Linear regression identified a strong positive correlation between the CT and R-time measured using the VCM Vet and TEG methods, respectively; no other parameters were correlated. CONCLUSIONS The use of VCM Vet is feasible in cats, and we determined the first described feline RIs for this test. In general, the VCM Vet data did not correlate with TEG in healthy cats.
Perspectives of Child Life Specialists After Many Years of Working With a Humanoid Robot in a Pediatric Hospital: Narrative Design

Background Child life specialists (CLSs) play an important role in supporting patients and their families during their visits to a children’s hospital. Although CLSs are equipped with considerable expertise to support families during some of the most difficult moments of their lives, we introduced an additional resource to them in the form of a humanoid robot named MEDi. Objective The aim of this study is to explore the experiences of CLSs using a robot to support children. Methods We interviewed 7 CLSs who had worked with this robot for several years. The transcribed interviews were analyzed using open and axial coding. Results The first main theme that emerged was the process of navigating from fear to friendship in learning to use a humanoid robot for therapeutic support. The second major theme was MEDi as a source of connection and support to children. CLSs’ perceptions of MEDi as an adaptable resource and working with the limits of MEDi constituted the last 2 themes. Conclusions These descriptions show how CLSs can incorporate a robot into their practice.
Can 68Ga-PSMA-11 PET/CT Predict Pathologic Response of Primary Prostate Cancer to Neoadjuvant Androgen Deprivation Therapy: A Pilot Study.

PURPOSE To explore the role of 68Ga-PSMA-11 PET/CT as a predictor of pathologic response to neoadjuvant androgen deprivation therapy (ADT) combined with abiraterone for high-risk prostate cancer (PCa). MATERIALS AND METHODS Forty-five patients with localized high-risk PCa who had serial 68Ga-PSMA-11 PET/CT scans before and after 6-month of ADT plus abiraterone neoadjuvant treatment, followed by radical prostatectomy, were included in this study. Complete pathologic response or minimal residual disease (MRD) <5 mm on whole-mount histopathology was defined as favorable pathologic response. The diagnostic performance of prostate-specific antigen (PSA) response and PET/CT response for favorable pathologic response was calculated. Univariable and multivariable logistic regression analyses of clinical and imaging variables were also performed to identify favorable pathologic response. RESULTS Compared to the PSA response, PET/CT response had a significantly higher specificity in diagnosing favorable pathologic response (89.7% versus 62.1%, p=0.043). Preoperative nadir PSA (OR 0.121, 95% CI 0.028-0.529, p=0.005), post-treatment SUVmax (OR 7.072, 95% CI 2.035-24.579, p=0.002), and post-treatment tumor volume (OR 7.896, 95% CI 1.415-44.054, p=0.018) measured on PET/CT were significantly associated with favorable pathologic response in univariable logistic regression analysis. In multivariable logistic regression analysis, only post-treatment SUVmax was found to be an independent predictor of favorable pathologic response (OR 9.69, 95% CI 1.439-65.242, p=0.020). CONCLUSIONS 68Ga-PSMA PET/CT has a better diagnostic performance of pathologic response to neoadjuvant treatment compared with PSA, with SUVmax being an independent predictive factor. This pilot study suggests that PSMA PET/CT may serve as a potential predictor of pathologic response to neoadjuvant treatment.
Current Practices and Existing Gaps of Continuing Medical Education among Resident Physicians in Abha City, Saudi Arabia

Background: Continuing medical education (CME) is an everlasting process throughout the physician’s working life. It helps to deliver better services for the patients. Objectives: To explore CME among resident physicians in Abha City; their current practices, their opinions, and barriers faced. Methods: A cross-sectional study was conducted among resident physicians at the Ministry of Health hospitals in Abha City using a validated self-administered questionnaire. It included personal characteristics, current CME practices, satisfaction with CME, and barriers to attendance. Results: The present study included 300 residents from 15 training specialties. Their reported CME activities during the previous year were lectures and seminars (79.7%) followed by conferences (43.7%), case presentations (39.7%), workshops (34.0%), group discussion (29/7%), and journal clubs (27.3%). Astonishingly enough, very few (8%) attended online electronic CME activities. There were significant differences in CME satisfaction scores by different training specialties. Regarding residents’ perceptions of the effectiveness of different CME activities (conferences/symposia, workshops/courses, and interdepartmental activities) the results showed that workshops and courses were significantly the most effective method compared to the other two methods in retention of knowledge, improving attitudes, improving clinical skills, improving managerial skills, and in improving practice behaviors. Barriers reported were being busy, lack of interest, high cost, and lack of suitable providers. Conclusion: Based on the findings of this study, it is recommended that online learning be promoted as a CME format for trainees. There should be support of residents and clinicians through the provision of protected time for their CME activities outside their daily clinical commitments.
Response of a peat bog vegetation community to long‐term experimental addition of nitrogen

We report results from a long‐term experiment in which additional nitrogen has been deposited on a peat bog in central Scotland for over 14 years, in three different forms: as ammonia (NH3) gas, as ammonium ( NH4+ ) solution, or as nitrate ( NO3- ) solution. The automated experiment was designed to apply nitrogen in such a way that mimics real‐world nitrogen deposition. Background nitrogen deposition at the site was 0.8 g N m−2 year−1). Observations of cover for 46 species were made. We analysed the change in six common species in relation to nitrogen dose and form. The responses differed among species and nitrogen forms, but five out of the six species declined, and NH3 produced the biggest change in cover per unit of nitrogen addition. The exception was the graminoid sedge Eriophorum vaginatum, which increased dramatically in the NH3 treatment. Multivariate analyses identified responses to nitrogen dose across treatments which were consistent with the univariate results. We surmised that the larger experimental response to nitrogen observed in the NH3 treatment (cf. the NH4+ and NO3- treatments) was because of the higher nitrogen concentrations at the vegetation surface produced by dry deposition. NH4+ and NO3- were sprayed in solution, but much of this will enter the peat porewater, and be further diluted. Because NH3 deposits directly to the leaf, it stays contained within the small volume of water on and in the leaf, producing a high internal concentration of nitrogen ions. Synthesis. Consistent trends with nitrogen were discernible across species. All species showed a decline with NH3 treatment, except for Eriophorum vaginatum which increased. In the absence of phosphorous and potassium (PK), all species declined with NH4+ and NO3- , except for Calluna vulgaris and Hypnum jutlandicum. The effect of PK was not consistent across species. Per unit of nitrogen deposited, NH3 generally had a larger impact on vegetation composition than NH4+ or NO3- . However, the actual deposition rate of NH3 on UK peat bogs is lower than the other forms. In the case of the most common species of the peat‐forming genus Sphagnum, we estimate that NH4+ deposition has the largest impact, followed by NO3- and NH3.
Evaluation of the effect of different light cure devices/modes on the micro-leakage of class V composite restoration. (A comparative in vitro study)

Introduction: Polymerization shrinkage has remained the major problem of composite restorations.This shrinkage can lead to micro-leakage between the composite material and tooth structure that adversely affect the longevity of the restoration. Many improvements of materials and curing devices had occurred to overcome these drawbacks. This study aimed to assess and compare the effects of different light cure devices/modes on the leakage of class V compositerestoration. Materials and Methods: A total of 64 standardized cavities (Cl V) were prepared on the buccal and palatal surfaces of 32 recently extracted human premolars. Teeth were divided randomly into 4 groups (N=8) according to the type of light curing unit used. All cavities were restored using flowable composite resin (3M ESPE) shade A2, and then they were finished and polished according to manufacturer's instructions. The specimens were subjected to thermocycling and dye immersion in 2% methylene blue. Then all teeth were sectioned longitudinally and examined for dye leakage scores under stereomicroscope with (40 X) magnification. Results: Using oneway ANOVA analysis and Student’s t-test.The results of this study revealed that there were statistically significant differences (p<0.01) between Standard continuous and other modes of LED light. Conclusion: The Standard continuous mode of light curing showed more microleakage than the other modes. The soft start polymerization showed the least microleakage. The gingival margins showed more microleakage than the occlusal margins in all groups.
Analisis Reaksi Pasar Dan Risiko Investasi Antara Perusahaan Perata Laba Dan Buka Perata Laba

The research aims to: 1) Analyzing is there any difference of market reaction between income smoothers and non income smoothers companies. 2) Analyzing is there any difference of investment risk between the income smoothers and non income smoothers companies. The research was done to manufactures companies listed in BEI. Among 149 manufactures companies listed in BEI, 48 companies were taken to become sample. Using Eckel Index, the sample were divided into two type, 9 income smoothers and 39 non income smoothers. Documentation technique was used to gather data. Independent sample t-test was used to analyzed data if it has normal distribution in Kolmogorov-Smirnov test. The result show that there was no difference of the market reaction between income smoothers and non income smoothers companies, and there was no difference of investment risk between income smoothers and non income smoothers companies. It’s because the result of independent sample t-test show the probability of amount market reaction and investment risk were not significant in 5%.
Effect of Petroleum Hydrocarbons Contamination on Soil Microorganisms and Biodegradation

The experiment under lab condition was conducted to investigate the effect of petroleum hydrocarbon contamination on soil microorganisms and biodegradation. The experiment was conducted in 12 treatment and three replication. The treatments include soil contaminated with Kerosene, Diesel, lubricate oil and used lubricate oil in three concentration 0%, 5%, and 10%. contamination with hydrocarbons significantly decreased the count of heterotrophic bacteria and there was reversal relationship between the contaminant concentration and the count of heterotrophic bacteria. The results indicated soil contamination with hydrocarbons significantly increased the count of Hydrocarbon Utilizing Bacteria (HUB). The effect of petroleum hydrocarbons on fungi count differed according to the type of hydrocarbons, concentration of contaminant and the periods of incubation. Our results show that soil contamination by hydrocarbons caused significant increase in actinomycetes count at all hydrocarbon types and concentrations except 5% used and non-used lubrication oil. The higher percentage of biodegradation in hydrocarbons contaminated soil 49.6% was recorded in soil contaminated with 5% kerosene while the lower percentag10.8% was recorded with soil contaminated 10% lubricate oil.
HCV and HIV co-infection among people who inject drugs in Vietnam

Introduction: HIV/HCV co-infection in people who inject drugs (PWID) continues to be a major challenge for health care systems and the PWID themselves. PWID have driven the HIV epidemic in Vietnam but information on HIV/HCV co-infection is limited. Methods: A cross-sectional study was conducted with 509 PWID recruited in Hanoi from February 2016 to April 2017. Four mutually exclusive groups were defined based on the presence of detectable HCV RNA and positive HIV confirmation. Multiple logistic regression analyses were performed to explore life-time risk behaviors of HCV mono-infection and HIV/HCV co-infection. Results: The overall prevalence of HIV and HCV infection was 51.08% and 61.69%, respectively. The prevalence of HCV mono-infection and HIV/HCV co-infection was 22.59% and 39.1%, respectively. We found that engaging in methadone maintenance treatment (MMT) was positively associated with HCV mono-infection (aOR = 2.38, 95% Confidential Interval [CI] 1.07 to 5.28) and with at least either HIV or HCV infection (aOR = 2.22, 95% CI 1.08 to 4.56). Ever being incarcerated was significantly associated with HCV mono-infection (aOR = 2.56, 95% CI 1.33 to 4.90) and HIV/HCV co-infection (aOR = 1.90, 95% CI 1.04 to 3.46). Those who had ever shared with and reused syringes/needles were more likely to have HIV/HCV co-infection (aORs = 5.17 and 2.86, P < 0001, respectively) and have either HIV or HCV infection (aORs = 3.42 and 2.37, P < 0001, respectively). Conclusion: Correlates for HCV mono-infection and HIV/HCV co-infection highlight the need to address risk behaviors, expand MMT programs, and establish HCV sentinel surveillance. The high prevalence of HCV and/or HIV co-infection shows a need for access to HCV treatment.
The Dual Role of Stakeholders in Collaborative Governance: Agro- Tourism in Indonesia

Agrotourism governance is an important mechanism in rural development and collaboration between stakeholders is needed. This paper aims to investigate the dual role of stakeholders in innovation building collaborative institutional networks and competitiveness of product, and to analyse the context of innovation model and enabling environment in collaborative governance for the development of sustainable agro-tourism. This article focuses on Cacao-based agrotourism in the Village Tourism ‘Bumi Mulyo Jati Mojopahit’, Mojokerto. The findings show that the dual role of stakeholders in innovation builds institutional networks and product competitiveness based on mutual trust and informal agreements, while the initiation of collaboration comes from the community. A difference in strength, resources, stakeholder knowledge and enabling environmental factors in the form of ties to religious organization relations, contribute to the development of sustainable agro-tourism. Experiences from this casestudy can contribute to the literature on collaborative governance in construction and discussion of the dual role of stakeholders.
Baccharis crispa attenuates toxic hepatitis induced by acetaminophen and carbon tetrachloride in mice

Aerial parts of Baccharis crispa are used as digestive and diuretic and are considered useful for hepatic, renal, and bladder diseases among others in Paraguayan folk medicine. The purpose of this study was to evaluate the effect of crude extract of B. crispa (CEBc) on acute hepatitis induced by acetaminophen and carbon tetrachloride in mice treated orally as a part of the validation procedure of the popular use. The hepato-protective effect of B. crispa against acute hepatitis induced by acetaminophen and carbon tetrachloride in mice were performed and liver function marker, aspartate transaminase (GOT), alanine transaminase (GPT) and alkaline phosphatase(ALP) were estimated. Increased serum levels of aspartate transaminase (AST = GOT), alanine transaminase (ALT = GPT), and ALP induced by both acetaminophen (350 mg/kg, i.p.) and CCl4 (1% in sunflower oil v/v, i.p.) given to mice were ameliorated by oral pretreatment with CEBc (50.0, 100.0, 200.0, and 300.0 mg/kg). Therefore, based on results, CEBc provoked a protecting effect on chemically induced acute liver injury, considering the transaminases and ALP serum level in two models of liver injury. The active compound(s) and mechanism of protection of B. crispa remain unclear and encourage us to pursue complementary chemical and pharmacological studies.
www.econstor.eu Managing a Conflict Alternative Dispute Resolution in Contests∗

We study the optimal design of alternative dispute resolution (ADR) mechanisms by a third-party mediator. ADR takes place before two litigants face each other in court. Litigation is a legal contest with players who are privately informed about the cost of collecting admissible evidence. Players update their beliefs after the mediation process, but before they decide on evidence collection. Different from standard mechanism design problems, the belief-system post-ADR is important for the outcome of the continuation game: within litigation, choice variables are similar to strategic complements and the evidence supplied is driven by the belief system. There is an incentive for parties to misreport in ADR to profit from this deviation in litigation should ADR fail to resolve the conflict. We show that optimal ADR has to break down on-path in some cases to screen the players with respect to their costs. Furthermore, ADR induces truthful reporting by creating post-breakdown beliefs which are independent of type-reports during ADR. To reduce inefficiency vis-à-vis symmetric litigation, optimal ADR induces asymmetric breakdown beliefs even for ex-ante symmetric types to increase the settlement rate compared to symmetric mechanisms. Independent of the set of parameters, ADR achieves settlement for the majority of cases.
Genetic and Serological Diversity of Chlamydia trachomatis Strains Detected from Japanese Infants

Background: Classical fifteen serovars and variants of Chlamydia trachomatis were originally classified by the micro-immunofluorescence test which principally distinguished epitopes on the major outer-membrane protein (MOMP). The sequences of MOMP gene including four variable domains (VDs) have been determined for all classic 15 serovars. The PCR assay was used to amplify a large part of the MOMP gene (ompA or omp1) including four VDs and then cataloged restriction fragment length polymorphism (RFLP) was used to identify the serovars from genotypes of C. trachomatis as reported previously. Materials and Methods: Nasopharyngeal specimens were collected from 15 Japanese infants with pneumonia, from 1 month to 1 year old, during the period May 1990 to September 2013. Conjunctival swabs were also collected from 12 Japanese neonates under 1 month old with inclusion conjunctivitis during the same period. The specimens were collected and placed into Abbott LCR proprietary medium and then tested by PCR for typing. The sequencing strategy used was the double-stranded DNA cycle sequencing method. Results: Applied to 15 reference strains, this PCR-RFLP procedure allowed us to determine 13 of the 15 serovars of C. trachomatis. Thirteen of 15 isolates of nasopharyngeal origin and 11 of 12 isolates of conjunctival origin could be un-equivocally assigned to one of the 15 reference serovars with a restriction endonuclease profile identical to that of the prototype. The typing of 15 nasopharyngeal isolates gave the following results: 11 as E, 2 as H, and 2 as unclassified serovars. The typing of 12 conjunctival isolates gave the following results: 5 as D, 4 as E, 1 as F, 1 as H and 1 as unclassified serovar. Among the unclassified serovars, one was B-like and the rest was D-like. Discussion: The sequences of MOMP gene for all classic 15 serovars allowed the construction of restriction endonuclease cleavage-site maps that confirm the fragment-size patterns observed by electrophoresis. Sequencing the entire MOMP gene and cataloging the sequences of VDs of all serovars has confirmed the molecular basis of the serotyping procedure and provided a method for determining serovars by PCR-RFLP. Although geno-variants have also been reported for most serovars the PCR-RFLP method for typing allows quick and objective identification of serovars of C. trachomatis. Antigenic variations of C. trachomatis were also considered among the strains from nasopharyngeal and conjunctival origins.