Miracle-dz/UniFAR-FTUs huggingface dataset:
Efficacy and safety of a specific commercial high-protein meal-replacement product line in weight management: meta-analysis of randomized controlled trials

Abstract Background Protein is suggested to be the nutrient providing the most satiety and is frequently used in meal-replacement products to achieve weight loss. Commercial products such as Herbalife high-protein (HP) products have been studied in various clinical trials, but controversy remains regarding their efficacy and safety. Methods We searched the PubMed, Center for Clinical and Translational Research (CCTR), and Google Scholar databases for randomized controlled trials of Herbalife HP products used as meal replacement (MR) published through July 2019 in peer-reviewed journals. We reviewed changes in efficacy and safety-related outcomes in treatment and control groups, and we estimated the pooled standardized mean difference (SMD) and corresponding 95% confidence intervals (CIs) with a DerSimonian and Laird random-effects method. Results By pooling data from nine identified studies (934 participants: 463 in treatment groups and 471 in control groups), we found that participants who consumed HP products experienced significantly larger decreases in body weight (SMD = −0.24; 95% CI: −0.37 to −0.10), body mass index (SMD = −0.31; 95% CI: −0.50 to −0.11), and fat mass (SMD = −0.37; 95% CI: −0.65 to −0.09) than did individuals consuming control diets. Concerning safety outcomes, the participants in the treatment group had a significantly larger decrease in aspartate aminotransferase (SMD = −0.23; 95% CI: −0.42 to −0.03). There were no significant between-group differences in alanine aminotransferase or creatinine. However, blood urea nitrogen levels increased in both groups, with a significantly larger increase in the treatment group (SMD = 0.53; 95% CI: 0.15 to 0.92). Conclusions Herbalife HP MR products appear effective and do not evidence significant risk in reducing body weight.
Pengaruh Pemahaman Akuntansi dan Pemahaman Perpajakan terhadap Kepatuhan Wajib Pajak pada KPP Pratama Madiun

The research aims to provide empirical evidence of the influence understanding of accounting and understanding of taxation on taxpayer compliance. Measurement of variables in this study using a Likert scale from scale 1 to strongly disagree to scale 4 to strongly agree. The sample in this study was 112 individual taxpayers in KPP Pratama Madiun. Sampling refers to the Slovin formula with a purposive sampling method and analyzed using multiple linear regression. The results of this study indicate that the understanding of accounting has no effect on taxpayer compliance while understanding of taxation has an effect on taxpayer compliance. Keywords: Understanding of Accounting; Understanding of Taxation; Taxpayer Compliance.
Oxindoles and Copper Complexes with Oxindole-Derivatives as Potential Pharmacological Agents

Oxindois sao compostos endogenos encontrados em fluidos e tecidos de mamiferos. Particularmente, isatina (1H-indol-2,3-diona) e seus derivados vem mostrando uma grande variedade de efeitos no meio biologico, incluindo a inibicao de monoamina oxidase, atividade bactericida, fungicida, antiviral e antiproliferativa. Pesquisas mais recentes descrevem estes compostos como inibidores de quinases, uma classe de proteinas envolvidas em varias etapas do ciclo celular. Nesta revisao, complexos de cobre(II) com ligantes derivados de oxindois sao discutidos como potenciais agentes antitumorais, em comparacao com outros complexos, com base na proposicao de se aliar as propriedades redox e coordenativas do metal a capacidade de afetar os processos de angiogenese e apoptose ja demonstrada por esse tipo de ligante. Oxindoles are endogenous compounds found in mammalian body fluids and tissues. Particularly, isatin (1H-indole-2,3-dione) and its derivatives have shown a variety of biological effects, including inhibition of monoamine oxidase, antibacterial, antifungal, antiviral and antiproliferative activities. Recent reports have described these compounds as efficient inhibitors of kinases, a class of proteins involved in many steps of the cellular cycle. Here, some copper(II) complexes with oxindole-derived ligands are discussed as potential antitumoral agents, in comparison to other complexes, based on the proposal of a synergistic effect on adding the metal coordinating and redox properties to the already demonstrated capability of these ligands to influence the angiogenesis and apoptosis processes.
Adaptation of Classical Swine Fever Virus in Cell Culture System and Confirmation by Electron Microscopy

Adaptation studies of  eld isolates of Classical Swine Fever (CSF) virus was carried out in Porcine Kidney (PK 15) cell line. Bulk culture of the virus at 25th passage was subjected to puri cation and concentration by ultracentrifugation and also con rmation by RT-PCR using NS5B primers. The Transmission Electron Microscopy (TEM) studies of CSF virus revealed 40-50 nm virus like particles which were surrounded by an asymmetrically arranged poorly de ned sac like membrane. This was taken as con rmation for the adaptation of the CSF virus in PK 15 cell line.
Characterization of soils cultivated with rubber in the Colombian Bajo Cauca Antioqueño region

From a socioeconomic and environmental standpoint, rubber cultivation is potentially important for Colombia, because it not only constitutes an alternative to the traditional mining, agricultural, and livestock activities, but also a beneficial option in the substitution of illegal crops. Thus, there is need to determine the factors restricting the productivity of the species, particularly soil-related aspects. In this context, the current research undertook the description and identification of soil physical and chemical properties in three rubber plantations located in a region known as Bajo Cauca Antioqueno, at the lower course of the Cauca river. The results indicate that these soils are classified as Ultisols, they are deep, with acid reaction and low levels of soil organic matter. Essential elements also exhibited low levels, except Cu. Fe and Al are also present in very high concentrations, while the cation exchange capacity is limited. These observations alert on the need for agronomic management techniques that allow the crop to express its full potential under conditions that are not very adequate for its growth and development
Triaging of Culture Conditions for the Enhanced Discovery of Secondary Metabolites from Different Bacteria

Over the past decade, the One Strain Many Compounds (OSMAC) approach has been established for silent gene cluster activation and elicitation of secondary metabolite production, but so far the full secondary metabolome of a biosynthetically promising bacterium has not been elucidated yet. Here, we investigate the ability of seven categories of OSMAC conditions to elicit new mass features from bacterial strains with little literature coverage but high biosynthetic potential. The strains B. amyloliquefaciens DSM7, C. coralloides DSM2259, P. fallax HKI727, R. jostii DSM44719 and S. griseochromogenes DSM40499 were selected after genome mining with antiSMASH. After cultivation under OSMAC conditions, the generated extracts were subjected to LC/MS and MZmine analysis to determine new mass features, expressed gene clusters and evaluate the tested culture conditions. 4 predicted compounds, bacillibactin, desferrioxamine B, myxochelin A and surfactin, were identified and up to 147 new mass features were detected in the generated extracts, which greatly surpasses the number of predicted gene clusters. Among the new mass features are bioactive compounds which were so far unreported for the strains such as cyclo-(TyrPro) from DSM7 and nocardamin from DSM2259. Furthermore, the tested culture conditions were evaluated regarding their suitability for the generation of new mass features from the selected strains and promising new starting points for further screenings are postulated. Especially culture conditions with little prior literature coverage are responsible for the activation of secondary metabolite production.
Colour Stability of Restorative Materials: A Spectrophotometric Study

Background: Colour stability of esthetic restorative materials is a crucial factor for restorations success. The aim of this study to determine the colour stability of two newly introduced composite resins after artificial aging in coffee and black tea. Materials and Methods: Disk-shaped specimens from each resin composite (Ceram X one, Dentsply, Germany and G-aenial, GC Corporation, Japan) were prepared and immersed in coffee, tea or distilled water for 24hours and one month. Colour measurements were made at baseline, 24hours and one-month intervals using a reflectance spectrophotometer (UV-VIS 2401PC, SHIMADZU, Japan) and the CIEDE2000 system. Statistical Analysis: Mean values and standard deviation were figured out for each specimen and data were statistically analysed with the use of IBM® SPSS® Statistics for Windows, Version 25. Results: For both time periods of immersion in coffee, there were no statistically significant differences between mean ? values of the tested materials (P>0.05). One month after immersion in tea, ? values of Ceram X one and G-aenial presented statistically significant difference (P<0.05). Conclusion: Coffee showed the greatest staining potential, followed by black tea. After one-month immersion in coffee, ? was material independent. Conversely, after one-month aging in tea, the colour difference ? E was material and time dependent.
Assessing chipper productivity and operator effects in forest biomass operations.

The present research focuses on the productivity of energy wood chipping operations at several sites in Italy. The aim was to assess the productivity and specifically the effect attributed to the operator in the chipping of wood biomass. The research included 172 trials involving 67 operators across the country that were analysed using a mixed model approach, in order to assess productivity, and to isolate the operator effect from other potential variables. The model was constructed using different predictors aiming to explain the variability due to the machines and the raw-materials. The final model included the average piece weight of raw material chipped as well as the power of the machine. The coefficients of determination (R2) were 0.76 for the fixed part of the model, and 0.88 when the effects due to the operators were included. The operators’ performance compared to their peers was established, and it was compared to a subjective classification based on the operator’s previous experience. The results of this study can help to the planning and logistics of raw material supply for bioenergy, as well as to a more effective training of future forest operators.
Voices of resilience: Female school principals, leadership skills, and decision-making techniques

In this article we report on a qualitative study which explored the life narratives and career trajectories of female school principals, to determine resilience factors in the principalship position. The female principals’ voices and lived experiences were principle focus areas, not barriers or challenges they faced. In-depth insights were provided by narrative analysis as research methodology. Fifteen in-service female principals were selected from one school circuit in the Mpumalanga province of South Africa. An interdisciplinary theoretical framework was used to guide the interpretation of the participants’ perspectives, using change theory, the ethics of care, and resilience psychology. Findings of the study reveal, among others, that female principals had to be prepared theoretically, practically, and psychologically for the principalship, and that mentoring and learning leadership skills were profoundly valued. These key factors lead to both career and life resilience, and can be imparted to prospective principals.
Performance of Vegetable Production and Marketing in Peri-Urban Kumasi, Ghana

Vegetable production and marketing play an important role in providing income and employment for a significant proportion of small holder farmers and traders in Ghana. Yet, farmers are dissatisfied, claiming that they earn less marketing margins than is due them as compared to traders in the value chain. Due to lack of a holistic assessment of actors’ performance, this assertion remains unjustifiable. It is against this backdrop that this study investigates the performance of farmers, wholesalers and retailers along the investment channels of three major leafy vegetables (spring onions, lettuce and cabbage) in peri-urban Kumasi. Using a two-stage sampling technique, a total of 217 actors comprising 147 farmers, 30 wholesalers and 40 retailers, were sampled. Marketing margin analysis and returns on investments (ROIs) were used to assess the performance of actors’ investments. Results show that vegetable production is dominated by males (91 percent) and trading by females (83 percent of wholesalers and 100 percent of retailers) respectively. Wholesalers recorded the highest yearly marketing margins for spring onions and cabbage (GH¢ 3 369 and GH¢ 17 376) (1US$ = GH¢ 3.6), while farmers obtained the highest yearly margins (GH¢ 3 630) for lettuce. Farmers obtained the most ROIs of 28, 145 and 79 percents for spring onions, lettuce and cabbage respectively. Based on accrued ROIs, the study concludes that farmers are more efficient in the investments in these vegetables than traders. Information flow gap was found to be a major cause of farmers’ scepticism on margin distribution because 76 percent of farmers had no information on market prices of products. It is recommended that an efficient policy on market price information system for vegetables be implemented via convenient means such as farmer associations and weekly radio broadcasts of product prices to all actors.
The Photocatalytic Degradation of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin in the Presence of Silver–Titanium Based Catalysts

Polychlorinated dibenzo-p-dioxins (PCDD) are persistent toxic compounds that are ubiquitous in the environment. The photodegradation of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the presence of silver titanium oxide (AgTi) and silver titanium doped into the Y-zeolite (AgTiY) was tested using high (254 nm) and mid (302 nm) energy UV irradiation sources. AgTi and AgTiY, both showed success in the photodegradation of 2,3,7,8-TCDD dissolved in methanol/tetrahydrofuran solution. Both catalysts were found to effectively decompose TCDD at 302 nm (lower energy) reaching in between 98–99% degradation after five hours, but AgTiY showed better performance than AgTi at 60 min reaching 91% removal. Byproducts of degradation were evaluated using Gas chromatography/mass spectrometry (GC–MS), resulting in 2,3,7-trichlorodibenzo-p-dioxin, a lower chlorinated congener and less toxic, as the main degradation product. Enzyme Linked Immunosorbent Assay (ELISA) was used to evaluate the relative toxicity of the degradation byproducts were a decrease in optical density indicated that some products of degradation could be potentially more toxic than the parent TCDD. On the other hand, a decrease in toxicity was observed for the samples with the highest 2,3,7,8-TCDD degradation, confirming that AgTiY irradiated at 302 nm is an excellent choice for degrading TCDD. This is the first study to report on the efficiency of silver titanium doped zeolites for the removal of toxic organic contaminants such as dioxins and furans from aquatic ecosystems.
Pathogenic Variability within Indian Alternaria brassicae Isolates Using Seed, Cotyledon and Leaf of Brassica Species

Thirty Alternaria brassicae (Berk.) Sacc. isolates from diverse geographical locations of India were studied for pathogenic variability on seed, cotyledon and true leaves of Brassica species. Seed germination was reduced maximum by isolate BAB-39 in Brassica juncea cultivar Varuna (22.1%), Brassica rapa var. Toria cultivar PT-303 (12%), Brassica carinata cultivar Kiran (12%), Brassica napus cultivar GSL-1 (11%) and tolerant source of B. juncea genotype PHR-2 (7%), although least by isolate BAB-49. Maximum lesion size on leaf was recorded in B. juncea cultivar Rohini (11.2, 16.5 and 16.8 mm) with isolates BAB-09 (Pantnagar), BAB-19 (Bharatpur) and BAB-39 (Kangra), respectively, and categorized as highly virulent, while minimum lesion size of 3.2, 3.7 and 3.8 mm was observed with isolates BAB-47 (Tonk), BAB 49 (Jobner) and BAB 04 (Kamroop), respectively, considered the weak isolates. On B. alba, BAB-09, BAB-19 and BAB-39 isolates caused maximum lesion size of 3.7, 3.8 and 3.9 mm, respectively, even though it showed maximum tolerance. In both seed and cotyledon inoculation method, the per cent Alternaria blight severity above 80% was observed with isolate of BAB-39 (91.5%), BAB-19 (89.0%), BAB-09 (85.5%) and least in isolate BAB-49 (34.0%). Brassica seed, cotyledon and leaf showed the similar positive response for categorizing A. brassicae isolates as virulent and avirulent. This information could be used to the development and assessment of resistant brassica germplasm, especially with A. brassicae populations exhibiting increased virulence.
Prevalence and in vitro antibiotic susceptibility pattern of bacterial strains isolated from tribal women suffering from urinary tract infections in District Anuppur, Madhya Pradesh, India

Introduction: Urinary tract infections (UTIs) are an increasing public health problem caused by a range of uropathogens. UTI is a major health concern among tribal women due to lack of adequate health facilities at regional public health centers and district hospitals. The objective of the study was to investigate the prevalence and antibiotic susceptibility of bacteria isolated from urine samples of tribal women suffering from UTI. Urine samples were collected from 550 tribal women who visited the Outpatient Department (OPD) of the District Hospital of Anuppur, Madhya Pradesh, India. Methods: The samples were cultured on different selective and differential media and identified by colony morphology, Gram staining and biochemical tests. Results: Out of 550 urine samples, 360 (65.45%) were culture-positive and 190 (34.55%) were culture-negative. Klebsiella pneumoniae, Proteus mirabilis, Escherichia coli & Pseudomonas aeruginosa have been identified as major uropathogens. K. pneumoniae is the most prevalent bacteria followed by P. mirabilis, E. coli and P. aeruginosa. The drug sensitivity analysis of bacterial uropathogens was performed against different antibiotics. The antibiotic susceptibility profiling showed that most of the isolates of K. pneumoniae, P. mirabilis and E. coli were resistant against penicillin (86.67-100%) and rifampicin (72.73-97.67%). Conclusions: Gentamycin, kanamycin and streptomycin were the most active antibiotics against the isolates of P. aeruginosa (76, 80 and 76%), P. mirabilis (76.62, 66.23 and 75.32%), K. pneumoniae (55.81, 20.93 and 44.19%) and E. coli (50.48, 37.14 and 62.86%), respectively, and may be the drug of choice for treatment of UTI in this region at present.
THE ANALYSIS OF XYLEM AND PHLOEM CELL NUMBER AND ANALYSIS OF THE SAPWOOD AREA PROPORTION IN NORWAY SPRUCE (PICEA ABIES (L.) KARST.) WITH VARIOUS STATE OF HEALTH

(L.) Karst. ) in the Drahany highlands. The research was conducted in six research plots. The first indicator of the state of health was the anatomical structure of the last xylem and phloem increment and cambium. The numbers of cells in individual types of tissues was evaluated with the aim to express the current growth potential. Further, the sapwood area proportion at breast height was analysed. This provides the information about the potential physiological activity of the entire stem section. The last type of data was the data from habitual diagnostics of woody plants. When analysing the sapwood area proportion, we found out that there is no statistically significant difference between means of particular plots. When analysing the numbers of cells in xylem in the latest ring, cambium and phloem, we found statistically significant differences among the research plots. However, these differences were not related to the proportion of sapwood or the data from habitual diagnostics. Based on the results, the basic hypothesis that the anatomical structure of xylem, cambium, and phloem, and the sapwood proportion can be used as one of the criteria for the evaluation of the state of health of woody plants was not confirmed. However, the contribution of the analysis of the selected indicators can be seen in the fact that the methods used and verified in the forestry practice (habitual diagnostics) were extended by data providing information about the physiological functionality of woody plants in the given conditions.
How innovative climate leads to project success: the moderating role of gender and work culture

Purpose In modern times, innovation is considered as a vital component of sustainable competitive advantage. The purpose of this paper is to identify how innovation at the individual level [innovative work behavior (IWB)] and at the organizational level [innovative organizational climate (IOC)] affects the chances of success of a particular project. Additionally, the moderating effect of gender and work culture on the relation between innovative climate and behavior is tested in the study. Design/methodology/approach Survey technique was used to collect data from 425 employees working in project departments at the executive, middle level and senior level management in the paint manufacturing industry of Pakistan. Multiple regression, as well as Preacher and Hayes (2004) tests, were applied to test the hypotheses. Findings The result of the data analysis showed that IWB acts as a mediator between IOC and project success (PS), thereby supporting the hypothesized model of innovation and PS. Work culture was supported as a moderator; however, no moderating effect of gender was validated by the results. Research limitations/implications The management must make sure that to maximize the rate of success of projects, innovative work climate within the organizations and departments be given due importance. In addition to this, personnel’s individual innovation capabilities must also be enhanced by taking steps toward improvement through training and development. Originality/value Though attention has been given to research in innovation in light of other related variables, its relation to PS remains yet to be studied. The effect of gender and work culture on innovation in Pakistani paint industry was long over-due which has been addressed by this study.