Miracle-dz/UniFAR-FTUs huggingface dataset:
Coulomb gauge ghost Dyson-Schwinger equation

A numerical study of the ghost Dyson-Schwinger equation in Coulomb gauge is performed and solutions for the ghost propagator found. As input, lattice results for the spatial gluon propagator are used. It is shown that in order to solve completely, the equation must be supplemented by a nonperturbative boundary condition (the value of the inverse ghost propagator dressing function at zero momentum), which determines if the solution is critical (zero value for the boundary condition) or subcritical (finite value). The various solutions exhibit a characteristic behavior where all curves follow the same (critical) solution when going from high to low momenta until forced to freeze out in the infrared to the value of the boundary condition. The renormalization is shown to be largely independent of the boundary condition. The boundary condition and the pattern of the solutions can be interpreted in terms of the Gribov gauge-fixing ambiguity. The connection to the temporal gluon propagator and the infrared slavery picture of confinement is explored.
Combined In Silico and In Vitro Evidence Supporting an Aurora A Kinase Inhibitory Role of the Anti-Viral Drug Rilpivirine and an Anti-Proliferative Influence on Cancer Cells

The global burden of cancer necessitates rapid and ongoing development of effective cancer therapies. One promising approach in this context is the repurposing of existing non-cancer drugs for cancer indications. A key to this approach is selecting the cellular targets against which to identify novel repurposed drugs for pre-clinical analysis. Protein kinases are highly sought-after anticancer drug targets since dysregulation of kinases is the hallmark of cancer. To identify potential kinase-targeted drug candidates from the existing portfolio of non-cancer therapeutics, we used combined in silico and in vitro approaches, including ligand-based 3D screening followed by biochemical and cellular assessments. This strategy revealed that the anti-viral drug rilpivirine is an Aurora A kinase inhibitor. In view of previous findings implicating Aurora A kinase in abnormal cell cycle regulation, we also examined the influence of rilpivirine on the growth of T47D breast cancer cells. Herein, we detail the identification of rilpivirine as an Aurora A kinase inhibitor, its molecular basis of inhibitory activity towards this kinase, and its Aurora A-mediated anticancer mechanisms in T47D cells. Our results illustrate the value of integrated in silico and in vitro screening strategies in identifying repurposed drug candidates and provide a scientific basis for further exploring the potential anticancer properties of the anti-viral drug rilpivirine.
Trimethylamine-N-Oxide Promotes Osteoclast Differentiation and Bone Loss via Activating ROS-Dependent NF-κB Signaling Pathway

Trimethylamine-N-oxide (TMAO), an important gut microbiota (GM)-derived metabolite, has been shown to be abnormally increased in osteoporosis. However, the role and underlying mechanism of TMAO in regulating bone loss during osteoporosis have not been fully investigated. In the current study, we found that 100–400 μM TMAO dose-dependently enhanced TRAP-positive osteoclasts, F-actin ring formation, and resorption area on bovine bone slices and up-regulated osteoclast-related gene expression (Calcr, Traf6, Dcstamp, Acp5, C-Fos, and NFATc1). Western blotting validated that TMAO not only activated NF-κB signaling pathway but also stimulated c-Fos and NFATc1 protein expression in a dose-dependent manner. Furthermore, BAY 11-7082, an NF-κB inhibitor, pretreatment markedly suppressed TRAP-positive osteoclast formation and osteoclast-related genes under TMAO treatment. BAY 11-7082 also inhibited p-p65/p65, c-Fos, and NFATc1 protein expression promoted by TMAO. Moreover, TMAO significantly increased ROS production, which was inhibited by N-acetylcysteine (NAC), an ROS antagonist. In addition, we proved that NAC pretreatment could inhibit TMAO-promoted NF-κB activation. NAC also suppressed TRAP-positive osteoclast formation, osteoclast-related gene expression, and protein expression of c-Fos and NFATc1 under TMAO treatment. In vivo studies showed significantly decreased bone mass and increased TRAP-positive osteoclasts in TMAO-treated C57BL/6 mice. Moreover, western-blotting and immunohistochemical staining showed that TMAO administration markedly stimulated NF-κB p65 expression. Additionally, TMAO administration significantly promoted the gene and protein expression of C-Fos and NFATc1. In conclusion, TMAO could promote osteoclast differentiation and induce bone loss in mice by activating the ROS-dependent NF-κB signaling pathway.
NEED AND AVAILABILITY OF NUTRIENTS FOR ADOLESCENT GIRLS

A total of 152 adolescent girls were studied using a standard questionnaire to find out their nutritional needs and availability. Average age of the subjects was 15.05±1.13 yrs. Mean age at menarche was 12.33±1.11 years. Protein rich food such as fish, meat, egg, pulse, groundnut, soybean, and different seeds were scantly in their daily diet. Vitamins and minerals containing foods such as vegetables, egg, milk and fruits were not consumed for last 24 hours by 40.48%, 69.48% and 70.0% of adolescent girls respectively. Carbohydrate containing foods were chosen by 32% of girls. About 52% of girls liked to consume protein-containing foods. Mineral and vitamin containing foods were chosen by 42% of girls. Colocasia leaves, Amaranths leaves (red) and pumpkin were liked to consume by 13%, 11.48% and 19.74% of adolescent girls. Amalaki, sour fruit and pine Apple were disliked by only 4.61%, 3.95% and 3.29% of girls. The average total food intake was 704.26 g. Which is less by 29% of the RDA (991 g). Average cereals intake has declined by about 4% of RDA. Consumption of pulses has seriously declined by about 44% of RDA. Consumption of vegetables was glaring deficit. It dropped by about 53% compared to RDA (112 g.). Fish and fruits were increased. Intake of milk decreased 77.14% when compared to RDA (250 Ml.). Average energy intake was 1697.68 Kcal. making 71.07% of the requirement but according South East Asia criteria of all girls to have normal BMI needs to study for its validity of large scale.
Body dissatisfaction and romantic relationship quality: A meta-analysis

Research has shown that there is an association between body dissatisfaction (a person’s negative evaluation of their own physical body) and romantic relationship satisfaction. Some have suggested that individuals with higher levels of body dissatisfaction report less satisfaction with their romantic relationships. However, others have suggested that there is a positive relationship between these two variables. This meta-analysis sought to examine the relationship between body dissatisfaction and relationship satisfaction. Possible moderators of this relationship were also examined. Fifty-six studies were meta-analyzed to quantitatively summarize the relationship between body dissatisfaction and relationship satisfaction. Additionally, participant body mass index (BMI), relationship length, gender, sexual orientation, and age were considered as potential moderators of this relationship. Results confirmed previous findings, indicating that body dissatisfaction was negatively associated with relationship satisfaction (rxy = −0.24). Furthermore, moderation analyses found that this negative relationship between body dissatisfaction and relationship satisfaction was attenuated as BMI increased. This relationship became stronger when the studies had higher female representation. Some sexual orientations also moderated the relationship. No moderating effects of age or relationship length were found.
Checks on temperature during on-wafer I-V characterization of Si diodes made with 2-D interfacial layers

Two hole-current extraction methods are discussed as potential checks on temperature during on-wafer I-V characterization of Si diodes made with 2-D interfacial layers on n-substrates. Both methods are unaffected by leakage currents related to defects near the junction. The one method is commonly used: the slope of the collector current in a lateral pnp Gummel plot is determined. The validity of this method is limited by series resistance and Early-voltage/punch-through effects related to depletion of the base region. The other method applies a differential measurement to determine a hole spreading current with an ideal slope. This method is not limited by depletion width variations but if the electron-to-hole current-ratio is too high, detrimental parasitic electron currents are induced.
Pulsed Vacuum Drying of Persimmon Slices: Drying Kinetics, Physicochemical Properties, Microstructure and Antioxidant Capacity

In order to explore an alternative drying method to enhance the drying process and quality of persimmon slices, pulsed vacuum drying (PVD) was employed and the effects of different drying temperatures (60, 65, 70, and 75 °C) on drying kinetics, color, rehydration ratio (RR), microstructure, bioactive compounds, and the antioxidant capacity of sliced persimmons were investigated in the current work. Results showed that the rehydration ratio (RR) of the samples under PVD was significantly higher than that of the traditional hot air-dried ones. Compared to the fresh samples, the dried persimmon slices indicated a decrease in the bioactive compounds and antioxidant capacity. The total phenolic content (TPC) of PVD samples at 70 °C was 87.96% higher than that of the hot air-dried persimmon slices at 65 °C. Interestingly, at 70 °C, the soluble tannin content and TPC of the PVD samples reached the maximum values of 6.09 and 6.97 mg GAE/g, respectively. The findings in the current work indicate that PVD is a promising drying method for persimmon slices as it not only enhances the drying process but also the quality attributes.
Experimental study on Ahmed’s body drag coefficient

The work presents an experimental designation of the aerodynamic drag coefficient for two configurations of the Ahmed body model, with slant angle of 25o and with the inactive synthetic jet generator. When analyzing the aerodynamic drag of vehicles, most authors focus on higher Reynolds numbers, describing lower values only by designated trend lines. Which is why the main contribution of this experimental work was to designate the Ahmed’s body drag coefficient for low Reynolds numbers and to verify the obtained results with other authors experiments especially with the trend lines for Reynolds number in the range 0,35x105 – 1,8x105. For data taken from the literature, it can be seen that the value of the drag coefficient for the Ahmed body model decreases when the Reynolds number increases. The results obtained during the experiment show the opposite tendency.
The viscosity of quark-gluon plasma at RHIC and the LHC

Abstract. The specific shear viscosity (η/s)QGP of quark-gluon plasma (QGP) can be extracted from elliptic flow data in heavy-ion collisions by comparing them with the dynamical model VISHNU which couples a viscous fluid dynamic description of the QGP with a microscopic kinetic description of the late hadronic rescattering and freeze-out stage. A robust method for fixing (η/s)QGP from the collision centrality dependence of the eccentricity-scaled charged hadron elliptic flow is presented. The systematic uncertainties associated with this extraction method are discussed, with specific attention to our presently restricted knowledge of initial conditions. With the (η/s)QGP extracted in this way, VISHNU yields an excellent description of all soft-hadron data from Au+Au collisions at top RHIC energy. Extrapolations to Pb+Pb collisions at the LHC, using both a purely hydrodynamic approach and VISHNU, are presented and compared with recent experimental results from the ALICE Collaboration. The LHC data are again well described by VISHNU, with the same (η/s)QGP value as at RHIC energies.
Elevated Extracellular HSP72 and Blunted Heat Shock Response in Severe COVID-19 Patients

Aims: We hypothesized that critically ill patients with SARS-CoV-2 infection and insulin resistance would present a reduced Heat Shock Response (HSR), which is a pathway involved in proteostasis and anti-inflammation, subsequently leading to worse outcomes and higher inflammation. In this work we aimed: (i) to measure the concentration of extracellular HSP72 (eHSP72) in patients with severe COVID-19 and in comparison with noninfected patients; (ii) to compare the HSR between critically ill patients with COVID-19 (with and without diabetes); and (iii) to compare the HSR in these patients with noninfected individuals. Methods: Sixty critically ill adults with acute respiratory failure with SARS-CoV-2, with or without diabetes, were selected. Noninfected subjects were included for comparison (healthy, n = 19 and patients with diabetes, n = 22). Blood samples were collected to measure metabolism (glucose and HbA1c); oxidative stress (lypoperoxidation and carbonyls); cytokine profile (IL-10 and TNF); eHSP72; and the HSR (in vitro). Results: Patients with severe COVID-19 presented higher plasma eHSP72 compared with healthy individuals and noninfected patients with diabetes. Despite the high level of plasma cytokines, no differences were found between critically ill patients with COVID-19 with or without diabetes. Critically ill patients, when compared to noninfected, presented a blunted HSR. Oxidative stress markers followed the same pattern. No differences in the HSR (extracellular/intracellular level) were found between critically ill patients, with or without diabetes. Conclusions: We demonstrated that patients with severe COVID-19 have elevated plasma eHSP72 and that their HSR is blunted, regardless of the presence of diabetes. These results might explain the uncontrolled inflammation and also provide insights on the increased risk in developing type 2 diabetes after SARS-CoV-2 infection.
Interstory Drift Estimation of Nonlinear Structure Using Acceleration Measurement with Test Validation

AbstractAn interstory drift-estimation method using structural acceleration measurements is presented in this study. In this method, the structural system, generally modeled with multiple-degree-of-freedom (MDOF) and Bouc–Wen hysteretic models, is decomposed into a series of single-degree-of-freedom (SDOF) substructures for interstory drift prediction. A virtual linear structural model, representing the linear behavior of the designed substructure, is used to generate reference response signals to obtain the tracking error of acceleration. The tracking error of displacement is subsequently estimated with the implementation of a robust Kalman-filtering approach, and the corresponding interstory drift of the objective substructure is then predicted accordingly. The prediction performance of interstory drift, in terms of peak drift and time history, is numerically investigated with two SDOF models and a four-story shear-beam model adopting different hysteretic characteristics. Results obtained by the present.
Valorization of Fish Processing By-Products: Microstructural, Rheological, Functional, and Properties of Silver Carp Skin Type I Collagen

The objective of this study was to develop aquatic collagen production from fish processing by-product skin as a possible alternative to terrestrial sources. Silver carp skin collagen (SCSC) was isolated and identified as type I collagen, and LC-MS/MS analysis confirmed the SCSC as Hypophthalmichthys molitrix type I collagen, where the yield of SCSC was 40.35 ± 0.63% (dry basis weight). The thermal denaturation temperature (Td) value of SCSC was 30.37 °C, which was superior to the collagen of deep-sea fish and freshwater fish. Notably, SCSC had higher thermal stability than human placental collagen, and the rheological experiments showed that the SCSC was a shear-thinning pseudoplastic fluid. Moreover, SCSC was functionally superior to some other collagens from terrestrial sources, such as sheep, chicken cartilage, and pig skin collagen. Additionally, SCSC could provide a suitable environment for MC3T3-E1 cell growth and maintain normal cellular morphology. These results indicated that SCSC could be used for further applications in food, cosmetics, and biomedical fields.
DISCOVERY OF A TIDAL DWARF GALAXY IN THE LEO TRIPLET

We report the discovery of a dwarf galaxy in the Leo Triplet. Analysis of the neutral hydrogen distribution shows that it rotates independently of the tidal tail of NGC 3628, with a radial velocity gradient of 35–40 km s−1 over approximately 13 kpc. The galaxy has an extremely high neutral gas content, accounting for a large amount of its total dynamic mass and suggesting a low amount of dark matter. It is located at the tip of the gaseous tail, which strongly suggests a tidal origin. If this is the case, it would be one of the most confident and nearest (to the Milky Way) detections of a tidal dwarf galaxy and, at the same time, the object most detached from its parent galaxy (≈140 kpc) of this type.
SEARCH FOR VERY LOW-MASS BROWN DWARFS AND FREE-FLOATING PLANETARY-MASS OBJECTS IN TAURUS

The number of low-mass brown dwarfs and even free floating planetary-mass objects in young nearby star-forming (SF) regions and associations is continuously increasing, offering the possibility to study the low-mass end of the initial mass function in greater detail. In this paper, we present six new candidates for (very) low-mass objects in the Taurus SF region one of which was recently discovered in parallel by Luhman et al. The underlying data we use is part of a new database from a deep near-infrared survey at the Calar Alto observatory. The survey is more than 4 mag deeper than the Two Micron All Sky Survey and covers currently ∼1.5 deg2. Complementary optical photometry from Sloan Digital Sky Survey were available for roughly 1.0 deg2. After selection of the candidates using different color indices, additional photometry from Spitzer/IRAC was included in the analysis. In greater detail, we focus on two very faint objects for which we obtained J-band spectra. Based on comparison with reference spectra, we derive a spectral type of L2 ± 0.5 for one object, making it the object with the latest spectral type in Taurus known today. From models, we find the effective temperature to be 2080 ± 140 K and the mass 5–15 Jupiter masses. For the second source, the J-band spectrum does not provide definite proof of the young, low-mass nature of the object, as the expected steep water vapor absorption at 1.33 μm is not present in the data. We discuss the probability that this object might be a background giant or carbon star. If it were a young Taurus member, however, a comparison to theoretical models suggests that it lies close to or even below the deuterium burning limit (<13 MJup) as well. A first proper motion analysis for both objects shows that they are good candidates for being Taurus members.
Research on the generality of icon sizes based on visual attention

Icon size is one of the key factors affecting the efficiency of information search. The advent of the era of intelligent interaction has made it difficult for icon design to meet the requirements of noncontact, large information volume, and high precision proposed by natural interaction technology in the future. At the same time, with the continuous improvement of display technology, the display resolution has been increased from 720 P to 8 K. Different sizes of display carriers use different resolutions. In order for icons to have efficient recognition at different display resolutions, it is necessary to obtain the best proportional relationship between icon size and display resolution. This paper summarizes the existing relevant research, calculates the ratio of recommended icon size and display resolution as the research variables, and comprehensively evaluates the recommended optimal ratio range of 1:641–1:334 through eye movement, EEG and behavioral response experiments and entropy‐weight TOPSIS method, providing a reference for icon design in various forms of interactive interfaces in the future.
X-ray bright active galactic nuclei in massive galaxy clusters - II. The fraction of galaxies hosting active nuclei

We present a measurement of the fraction of cluster galaxies hosting X-ray bright Active Galactic Nuclei (AGN) as a function of clustercentric dista nce scaled in units of r500. Our analysis employs high quality Chandra X-ray and Subaru optical imaging for 42 massive Xray selected galaxy cluster fields spanning the redshift ran ge of 0.2< z< 0.7. In total, our study involves 176 AGN with bright (R< 23) optical counterparts above a 0.5− 8.0 keV flux limit of 10 −14 erg cm −2 s −1 . When excluding central dominant galaxies from the calculation, we measure a cluster-galaxy AGN fraction in the central regions of the clusters that is ∼ 3 times lower that the field value. This fraction increases wit h clustercentric distance before becoming consistent with the field at ∼ 2.5r500. Our data exhibit similar radial trends to those observed for star formation and optically selected AGN in cluster member galaxies, both of which are also suppressed near cluster centers to a comparab le extent. These results strongly support the idea that X-ray AGN activity and strong star formation are linked through their common dependence on available reservoirs of cold gas.
Non-adiabatic dark fluid cosmology

We model the dark sector of the cosmic substratum by a viscous fluid with an equation of state p = −ζΘ, where Θ is the fluid-expansion scalar and ζ is the coefficient of bulk viscosity for which we assume a dependence ζ∝ρν on the energy density ρ. The homogeneous and isotropic background dynamics coincides with that of a generalized Chaplygin gas with equation of state p = −A/ρα. The perturbation dynamics of the viscous model, however, is intrinsically non-adiabatic and qualitatively different from the Chaplygin-gas case. In particular, it avoids short-scale instabilities and/or oscillations which apparently have ruled out unified models of the Chaplygin-gas type. We calculate the matter power spectrum and demonstrate that the non-adiabatic model is compatible with the data from the 2dFGRS and the SDSS surveys. A χ2-analysis shows, that for certain parameter combinations the viscous-dark-fluid (VDF) model is well competitive with the ΛCDM model. These results indicate that non-adiabatic unified models can be seen as potential contenders for a General-Relativity-based description of the cosmic substratum.
IRAS 03063+5735: A BOWSHOCK NEBULA POWERED BY AN EARLY B STAR

Mid-infrared images from the Spitzer Space Telescope Galactic Legacy Infrared MidPlane Survey Extraordinaire program reveal that the infrared source IRAS 03063+5735 is a bowshock nebula produced by an early B star, 2MASS 03101044+5747035. We present new optical spectra of this star, classify it as a B1.5 V, and determine a probable association with a molecular cloud complex at VLSR = −38 to −42 km s−1 in the outer Galaxy near ℓ = 140. °59, b = −0. °250. On the basis of spectroscopic parallax, we estimate a distance of 4.0 ± 1 kpc to both the bowshock nebula and the molecular complex. One plausible scenario is that this is a high-velocity runaway star impinging upon a molecular cloud. We identify the H ii region and stellar cluster associated with IRAS 03064+5638 at a projected distance of 64 pc as one plausible birth site. The spectrophotometric distance and linkage to a molecular feature provides another piece of data helping to secure the ill-determined rotation curve in the outer Galaxy. As a by-product of spectral typing this star, we present empirical spectral diagnostic diagrams suitable for approximate spectral classification of O and B stars using He lines in the little-used yellow–red portion of the optical spectrum.