Miracle-dz/UniFAR-FTUs huggingface dataset:
Ectoparasite Fauna of Commensal Rodents Collected from the North Sinai Governorate - Egypt and its Public Health Significance

| Rodents have a huge impact on the natural environment. Rat and mice are considered a natural host for a large number of ectoparasites. The present study aimed to determine the geographical distribution and ectoparasites infestation rates of commensal rats and mice collected from the North Sinai governorate Egypt. The survey was conducted during the period from December 2016 to November 2017 in three different locations namely Bir el-`Abd city, Rabaa, and Qatia villages located in the North Sinai governorate. The ectoparasites were isolated from four species of rodents including Rattus norvegicus (Brown rats), Rattus rattus frugivorus (Black rats), Rattus rattus alexandrinus, and Mus musculus (House mouse). The survey recovered and identified three species of fleas including Echidnophaga gallinacea, Xenopsylla cheopis, and Leptopsylla segnis, four species of lice including Hoplopleura hirsute, Hoplopleura ocanthopus, Hoplopleura oenomydis, Polyplax spinulosai, and five species of mites including Laelaps nuttalli, Dermanyssus gallinae, Ornithonyssus bacoti, Myobia musculi, Allodermanyssus sanguine. The distribution of the ectoparasites was identified according to several factors including rodent species, sex, location, and seasonal effects and the zoonotic role of some of the identified rodent ectoparasites was discussed.
Light-guided intrabodies for on-demand in situ target recognition in human cells

Due to their high stability and specificity in living cells, fluorescently labeled nanobodies are perfect probes for visualizing intracellular targets at an endogenous level. However, intrabodies bind unrestrainedly and hence may interfere with the target protein function. Here, we report a strategy to prevent premature binding through the development of photo-conditional intrabodies. Using genetic code expansion, we introduce photocaged amino acids within the nanobody-binding interface, which, after photo-activation, show instantaneous binding of target proteins with high spatiotemporal precision inside living cells. Due to the highly stable binding, light-guided intrabodies offer a versatile platform for downstream imaging and regulation of target proteins.
Establishing trends in ion adsorption on the aqueous aluminium hydroxide nanoparticle Al30

The fact that chemical reactions at environmental interfaces are becoming accessible to quantum mechanical computational studies provides geochemical researchers with a new means to predict properties that cannot readily be measured and to develop molecular-level understanding of geochemical model systems. Recent computational studies of Cu2+ and adsorption onto the Keggin-based aqueous aluminium nanoparticle (), or Al30, revealed opposing trends in adsorption site preference as a function of molecule surface topology. Specifically, the adsorption site favourable for the inner-sphere adsorption of Cu2+ is on the caps of Al30 while outer-sphere prefers adsorption in the so-called beltway region of the molecule. When co-adsorbed, it is predicted that both species adsorb in the beltway, consistent with an experimental crystal structure. Here, we discuss results for individual cation and anion adsorption to Al30. Our goals are to better understand how the adsorbate properties govern interactions with Al30 and to assess whether generalisations can be formed. We test the reactivity of cations (Cu2+, Pb2+, Zn2+) and anions (, Cl− ) to aqueous Al30 by using density functional theory modelling. It is determined that all the cations favour the adsorption sites on the caps of Al30 and both anions favour outer-sphere adsorption in the beltway region. The results are discussed in terms of the electrostatic potential of Al30 and three-dimensional induced charge density mapping.
Antimicrobial-resistant bacteria in food: which behaviour change strategies increase consumers’ risk awareness and preventive food-handling behaviour?

ABSTRACT Objectives We aimed to identify the potential of behaviour change strategies to effectively increase consumers’ risk awareness, behavioural intention, and preventive food-handling behaviour to reduce the transmission risk of antimicrobial-resistant bacteria through food. The applied strategies targeted knowledge and determinants of the health action process approach (HAPA). We tested techniques that are expected to increase knowledge, risk perception, and positive outcome expectancy (Study 1) as well as those that increase planning and coping self-efficacy (Study 2) in two randomised control trials. Methods In Study 1 (N = 328), a 2 × 2 between-subject design was employed to investigate the effects of an educational video about the spread of antimicrobial-resistant bacteria and a personalised risk message on knowledge, risk perception, outcome expectancy and consequently on intention regarding safe food-handling behaviour. In Study 2 (N = 129), we used a 2 × 2 design to examine to what extent goal setting (implemented vs. not implemented) and time (pre- vs. post-test) affected planning, coping self-efficacy, and preventive food-handling behaviour. Results In Study 1, we found that the video increased knowledge and the perceived susceptibility of risk compared to the control video. We found no increase on the dependent variables after receiving the personalised risk message. In Study 2, goal setting significantly improved safe food-handling behaviour compared to the control condition. Moreover, participants in the goal-setting condition showed more planning of safe food-handling measures and of dealing with emerging barriers than participants in the control condition. Conclusions These findings demonstrate that the delivery of an educational video on the spread of antimicrobial-resistant bacteria is a useful strategy to increase risk awareness, whereas goal setting presents a promising approach to improve food-handling behaviour. Following the HAPA, an additional effective behaviour change technique is required that decreases negative outcome expectancies and improves coping self-efficacy, thereby further improving intention and behaviour.
International Journal of Food Engineering Effect of Wine Properties and Operating Mode upon Mass Transfer in Micro-Oxygenation

All along wine-making and during its ageing, oxygen plays an important role for the evolution of the wine. Solubilization of oxygen into musts or wines occurs when gaseous oxygen is brought into contact with the liquid. In this work, the specific technique of wine microoxygenation is addressed through the evaluation of transfer capacity for oxygen solubilization. This was done considering the parameters likely to influence the saturation concentration of dissolved oxygen and the conventional volumetric mass transfer coefficient kLa, which quantifies the efficiency of the oxygen transfer. The study has shown that the sugar concentration in the must induces a viscosity enhancement which leads to a significant decrease of the kLa value. Surprisingly, it was also observed that a very low quantity of ethanol in the liquid phase (0.05 percent volume) strongly favours the oxygen transfer. Conversely, the presence of dissolved carbon dioxide in the wine, which desorbs and dilutes the oxygen in the micro-bubbles, dramatically decreases the transfer of oxygen. The presence of anti-oxidant compounds (SO2) or oxygen consumer compounds (polyphenols) was shown to have no effect upon the efficiency of oxygen transfer. Operating parameters such as gas flow rate or geometrical aspect of the tank have also been considered.
Analisis Pengaruh Karakteristik Komite Audit dan Struktur Kepemilikan terhadap Manajemen Laba pada Perusahaan yang Terdaftar di Bursa Efek Indonesia

Penelitian ini bertujuan untuk mengetahui pengaruh karakteristik komite audit dan struktur kepemilikan terhadap manajemen laba pada perusahaan yang terdaftar di Bursa Efek Indonesia (BEI). Variabel dependen yang diteliti merupakan manajemen laba yang diukur dengan modified Jones Model. Variabel-variabel independen yang digunakan dalam penelitian ini berupa independensi komite audit, keahlian komite audit, kerajinan komite audit, ukuran komite audit, kepemilikan asing, kepemilikan institusi, kepemilikan manajerial, kepemilikan pemerintah, dan kepemilikan individu. Adapun variabel kontrol seperti ukuran perusahaan, leverage, tingkat pengembalian aset, dan arus kas dari kegiatan operasi juga digunakan dalam penelitian ini. Sampel dari penelitian ini adalah 1.363 data observasi atau setara dengan 324 perusahaan yang terdaftar di BEI pada periode 2011-2015. Sampel dipilih dengan menggunakan metode purposive sampling. Data yang digunakan dalam penelitian ini adalah laporan tahunan dari seluruh perusahaan yang diterbitkan di situs www.idx. co.id atau situs resmi perusahaan. Data yang telah diperoleh diuji dengan metode regresi panel menggunakan bantuan perangkat lunak statistik. Hasil dari penelitian ini menunjukkan bahwa kepemilikan institusi, ukuran perusahaan, tingkat pengembalian aset, dan arus kas kegiatan operasi mampu mempengaruhi manajemen laba secara signifikan, baik positif maupun negatif. Variabel-variabel lain seperti independensi komite audit, keahlian komite audit, kerajinan komite audit, ukuran komite audit, kepemilikan asing, kepemilikan manajerial, kepemilikan pemerintah, kepemilikan individu, dan leverage tidak terbukti mampu mempengaruhi manajemen laba secara signifikan.
Pretesting a Poster on Recommended Stress Management During the COVID-19 Pandemic in Indonesia: Qualitative Study

Background The COVID-19 Peritraumatic Distress Index (CPDI) is a self-report questionnaire developed to evaluate the frequency of anxiety and depression symptoms among individuals during the COVID-19 pandemic. A recent study in China showed high CPDI scores among individuals in the 18-30 years age group and those over 60 years. During the COVID-19 outbreak, people were expected to maintain their mental health conditions, especially stress levels. Therefore, many national governments actively published health promotion media in an effort to educate the public. One such media developed by the Ministry of Health, Republic of Indonesia, was a poster titled “Hindari Stres dan Tetap Optimis dengan Melakukan Aktivitas Sehari-hari dan Tetap Menjaga Jarak. ” Objective The aim of this study is to conduct a test on a stress management recommendation poster developed by the Ministry of Health, Republic of Indonesia, in response to the COVID-19 outbreak by using pretesting communication theory. Methods In-depth interviews were conducted among 8 key informants and 1 graphic design expert. Results Pretesting can identify the strengths and weaknesses of media. The large amount of text and the lack of illustrations made the poster less attractive to readers. Moreover, there was a discrepancy between the title and contents of the poster. The poster was not able to persuade the informants to change their behavior in the near future. Conclusions The poster was understood and accepted by the informants, but there was still much to be improved considering the poster was a product of the Ministry of Health, Republic of Indonesia.
Neoadjuvant chemotherapy or surgery: which is the optimal initial option for T3 breast cancer (> 5 cm)——a real world research from Chinese society of clinical oncology breast cancer database

Background: The objectives were to explore the real world treatment of T3 breast cancer (maximum diameter of tumor bigger than 5 centimeters). Materials and Methods: We selected T3 breast cases diagnosed from 2011 to 2017 in the CSCO BC database. These cases were categorized into two groups: non-NAC group and NAC group. Adjusted hazard ratios for known predictors of event free survival (EFS) using Kaplan-Meier and Cox proportional hazards regression. Results: The study included 868 patients: 49.0%(425/868) of patients chose NAC after diagnosis, 51.0%(443/868) chose surgery as their initial therapeutic strategy(non-NAC group). Compared with non-NAC group, patients in NAC group were correlated with clinical positive lymph nodes, hormonal receptor(HR) negative and human epidermal receptor growth factor 2(HER2) positive. For non-NAC group, only 87.1%(386/443) of patients were pathologic T3 after surgery, the overestimation of clinical examination of tumor lesion was 12.9%(57/443). In addition, there was no significance of EFS between the NAC group and non-NAC group(HR=0.82, 95%CI: 0.64-1.05). However, for T3 breast cancer patients with positive lymph nodes, HR negative and HER2 positive tumors, the NAC group had a better survival than the non-NAC group. Cox proportional analysis showed that lymph node negative, HER2 negative status and neoadjuvant chemotherapy were associated with a longer survival time. Conclusion: As the initial option for T3 breast cancer patients with positive lymph nodes, HR negative and HER2 positive tumors, neoadjuvant chemotherapy is the first therapy.
Amyloid-β Protein and Neuroglobin Protein as Biomarkers on Brainstem Following Traumatic Brain Injury in Rats

Background: Biomarkers play an important role in accurate diagnosis of traumatic brain injury (TBI). Due to the complexity and diversity of TBI, it is likely that a single biomarker will not be used for exactly diagnose. Amyloid-beta (Aβ) protein is generated by sequential cleavage of amyloid precursor protein (APP) by β- and γ-secretase, which may exert its toxic effects by increasing reactive oxygen species and neuroinflammation in the brain as damage factor of TBI. Its use in diagnosis for TBI is becoming more widespread. Neuroglobin (NGB) protein is great potential to diminish neuronal damage. Most epidemiological evidence suggested that Aβ and NGB may be used as biomarkers on brainstem (BS) following TBI. The aim of this study was to investigate the trend of Aβ and NGB on BS of rats with TBI and to analyze comprehensively them as potential biomarkers. Methods: Adult male Sprague-Dawley rats were subjected to the modified weight-drop model of closed TBI. Biologic behavior observation, histopathological assessments and western blot assay were performed. Aβ and NGB expression indicated temporal changes in BS after TBI. Their accuracy and efficiency of performing these tasks were calculated and statistical comparisons performed.Results: The results of Aβ enable us to speculate that the time points of 3 h, 6 h and 12 h may be crucial points for the diagnosis of TBI. NGB expression in the injured had obvious difference versus the control, the points of 1 h and 3 h were apparently higher than the control, and the groups of 12 h and 48 h were two peaks in the present study. Furthermore, the immunofluorescence assay results supported that Aβ and NGB co-localization in the neuros of BS, and the NGB specific expression in the BS of neurons.Conclusions: Therefore, the expression and change rules of Aβ and NBG in the BS may provide an important foundation for the diagnosis of TBI, damage assessment and therapeutic intervention.
Trajectories of Change in an Open-access Internet-Based Cognitive Behavior Program for Childhood and Adolescent Anxiety: Open Trial

Background Although evidence bolstering the efficacy of internet-based cognitive behavioral therapy (iCBT) for treating childhood anxiety has been growing continuously, there is scant empirical research investigating the timing of benefits made in iCBT programs (eg, early or delayed). Objective This study aims to examine the patterns of symptom trajectories (changes in anxiety) across an iCBT program for anxiety (BRAVE Self-Help). Methods This study’s participants included 10,366 Australian youth aged 7 to 17 years (4140 children aged 7-12 years; 6226 adolescents aged 12-17 years) with elevated anxiety who registered for the BRAVE Self-Help program. Participants self-reported their anxiety symptoms at baseline or session 1 and then at the commencement of each subsequent session. Results The results show that young people completing the BRAVE Self-Help program tend to fall into two trajectory classes that can be reliably identified in terms of high versus moderate baseline levels of anxiety and subsequent reduction in symptoms. Both high and moderate anxiety severity trajectory classes showed significant reductions in anxiety, with the greatest level of change being achieved within the first six sessions for both classes. However, those in the moderate anxiety severity class tended to show reductions in anxiety symptoms to levels below the elevated range, whereas those in the high symptom group tended to remain in the elevated range despite improvements. Conclusions These findings suggest that those in the high severity group who do not respond well to iCBT on a self-help basis may benefit from the additional support provided alongside the program or a stepped-care approach where progress is monitored and support can be provided as necessary.
Immune Status Against Newcastle Disease Virus in Backyard Poultry of Punjab Province, Pakistan

| Newcastle Disease (ND) is one of the most important health problem of commercial and backyard poultry. It is producing significant economic losses due to fatalities globally. The objective of the study was to carried out serum base investigation regarding the Newcastle disease Virus (NDV) antibody occurrence in different seasons of a year. The data were documented has current immune status of unvaccinated backyard poultry. A total of 1468 sera samples were collected from 32 districts of Punjab, Pakistan. Using Haemagglutination inhibition (HI) test, the serum Ab titer was measured and maximum seroprevalence (92%) was discovered in the Sargodha district, whereas Mianwali showed lowest seroprevalence (15.25%). Overall seropositivity (58.78%) was observed between 4log2 and 9log2 antibody titer and average geometric mean titer (GMT) was 16.59. Furthermore, the presence of serum base antibodies of NDV was found higher in summer season (64.50% with 21.38 GMT) but decreased in winter season (50% with 15.13 GMT). In the absence of the vaccine, the results provide a clear evidence of exposure to NDV to backyard poultry. Hence, systemic sero-surveillance is needed to counter the ever-increasing risk of NDV in backyard poultry.
Effect of mulching and supplementary irrigation on fruit set, fruit drop, fruit retention and yield of bael (Aegle marmelos Correa.)

An experiment was conducted at Horticultural Research Station, Mondouri, BCKV during 2015-2017 to find out the effect of mulching and supplementary irrigation on fruit set, fruit drop, fruit retention and yield of Bael (Aegle marmelos Correa.). The experiment was put on factorial RBD consist of nine treatments viz. M0I0 No mulch + no irrigation (control), M0I1 No mulch + basin irrigation @ 15 litres plant-1 at 10 days interval, M0I2 No mulch + basin irrigation @ 15 litres plant -1 at 20 days interval, M1I0 Black polythene mulching + no irrigation M1I1 Black polythene mulching + basin irrigation @15 litres plant 1 at 10 days interval, M1I2 Black polythene mulching + basin irrigation @15 litres plant -1 at 20 days interval. M2I0 Dry leaves mulching + no irrigation, M2I1 Dry leaves mulching + basin irrigation @15 litres plant -1 at 10 days interval, M2I2 Dry leaves mulching + basin irrigation @15 litres plant-1 at 20 days interval. Which are interaction of two factor i.e. mulching and irrigation and each treatment has three replications. Result of the investigation revealed that mulching with black polythene followed by no irrigation (M1I0) before flowering improves fruit set (68.67%) than any other treatments. Black polythene mulching + basin irrigation 15 litres plant-1 at 10 days interval (M1I1) was most effective in improving fruit retention (16.33%) and fruit yield plant-1 (34.49 kg) followed by dry leaves mulching + basin irrigation 15 litres plant-1 at 10 days interval (M2I1).
Single cell transcriptomics of human nephritis reveal the cellular origin of kidney disease associated genes

Background Single cell RNA sequencing (scRNA-seq) have become a powerful tool in discovering a novel cell type and pinpointing cellular specific gene within tissues. However, in diseased kidneys, especially caused by glomerulonephritis, there have few study focusing on revealing gene expression changes at the cellular level. Methods To reveal cellular gene expression profiles of glomerulonephritis, we performed scRNA-seq of 2 human kidney transplantation donor samples, 4 human glomerulonephritis samples, 1 human malignant hypertension sample and 1 human chronic interstitial nephritis sample, all tissues were taken from biopsy. Results Upon disease occur, immune cells infiltrate which can be proved by our dataset. In the cluster of podocyte, two glomerulonephritis related genes named FXYD5 and CD74 were found, and interferon alpha/beta signalling pathway and antigen processing and presentation was enriched in podocyte of LN and IgAN comparing with other samples, thus inhibiting these signalling pathway may alleviate the symptom of these disease. Conclusions Cellular origin of kidney disease associated genes and the activated signaling pathways the genes involved in can be found by scRNA-seq.
Global Reaction Kinetics of CO and CO2 Methanation for Dynamic Process Modeling

For the design and optimization of methfanation processes detailed modeling and simulation work is advisable. However, only a few kinetics published in literature rely on wide temperature and pressure ranges, which are prevalent at modern methanation applications with dynamic operation. Especially the simulation-based design of methanation processes with commercial catalysts is difficult due to legal restrictions regarding the publication of kinetic data of those catalysts. In this work, rate equations for the dynamic modeling and simulation of methanation processes operating with commercial Ni/Al2O3 catalysts are selected, adapted, and tested in a dynamic reactor model. The results suggest that the catalyst's nickel content is an indicator for the choice of a rate equation. Testing of the equations in a reactor model meets published data for CO and CO2 methanation and own measurements.
Growth Performance and In vivo Nutrients Digestibility of Growing Yankasa Ram Lambs Fed Diets Containing Graded Levels of Sesame Residue

| The study was carried out to evaluate the effect of including sesame residue (SR) in the diets of Yankasa ram lambs on feed intake, body weight gain, and nutrients digestibility. Twelve Yankasa ram lambs (initial body weight of 20.08 ± 3.08kg) were allotted to three dietary treatments containing 0, 20 and 30% SR (A, B and C) respectively. A completely randomized design was used for the study which lasted twelve weeks. The results revealed that animals fed 30% inclusion level had higher dry matter, nitrogen free extract and ether extract intakes, which varied among the treatments. Organic matter, neutral detergent fiber and acid detergent fiber digestibilities were higher for the lambs fed 0% SR. Inclusion of sesame residue up to 30% in the diet of growing Yankasa lambs improved nutrients intake without adverse effects on growth performance. It is thus recommended that sesame residue could be incorporated in the diets of growing Yankasa lambs at 30% inclusion level for reduced feed cost in Sudan Savanna agro-ecological zone of Nigeria.