Miracle-dz/UniFAR-FTUs huggingface dataset:
The Effect of Selected Traditional Herbal Combination with Royal Jelly on Kidney Function: Case Series

Aim: This retrospective case study was conducted to investigate the effect of using a herbal mixture herbal mixture (which is composed of corn silk ( Stigma maydis) , Paronychia arabica (paronychia), Frankincense ( Gum olibanum ) and Asparagus racemosus roots (shatavari)) accompanied with Royal Jelly capsules on renal function assessed by serum creatinine level. Methodology: This study was conducted by reference to computer patients' files between 2015 and 2018 in Herbal Dynasty Medical Center, Amman, Jordan. A 20 cases of renal failure patients of both sexes (9 females’ and 11 males) (age range 23 to 71 years) were selected. Serum creatinine before and after the treatment were reported. Also, estimated Glomerular Filtration Rates (eGFR) were calculated. Results: Mean serum creatinine levels after herbal treatment for all selected cases were decreased by (2.8 ± 1.4) as compared to mean serum creatinine levels before the treatment (3.9 ± 1.8). The majority of patients have been transmitted from advanced stages of CKD to lower stages based on eGFR. Conclusion: The use of herbal and alternative therapies in CKD lead to a decrease of serum creatinine levels and to transition patients from advanced stages to another lower; which means that treatments enhance kidney function and decrease deterioration
Phytosociology of the Tree Community of Gandhamardan Hill Ranges

Phytosociological study of the tree community was carried out in tropical dry deciduous forest of Gandhamardan hill ranges belonging to Eastern Ghats at Harishankar of Bolangir district, Orissa, India. Twenty five quadrates of 20×20m size (Area=10000m 2 =1ha) were laid in the lOOha protected forest (N = 20° 51' 027", E = 82° 51' 59.2") of Harishankar complex along GPS locations covering its whole geography. Tree (GBH≥ 15cm) stand density was 743ha -1 . A total of thirty two tree species were found which includes 30 genera and 20 families. Top five species holding highest IVI value are Shorea robusta Gaertn.f, Diospyros melanoxylon Roxb, Haldinia cordifolia (Roxb.) Ridsdak. Pterocarpus marsupium Roxb. and Anogeissus latifolia (Roxb.ex DOWall.ex Guill. & Perr. Eight species are randomly distributed and twenty four are contiguously distributed while none of them showed regular in distribution. All individuals of tree species have been grouped into 20 girth classes. The Shannon-Wiener (H') diversity index of studied site is 1.35 with Simpson's value 0.921. This study reveals prevalent clumping nature of the tree community in the natural forest of Gandhamardan hill ranges.
Bite Wounds and Dominance Structures in Male and Female African Spiny Mice (Acomys cahirinus): Implications for Animal Welfare and the Generalizability of Experimental Results

Simple Summary Animals often inflict bite wounds in laboratory housing, compromising animal welfare and, potentially, experimental results. For example, 1.5–14% of male laboratory mice (Mus musculus) obtain bite wounds over the course of a year. Recently, spiny mice (Acomys cahirinus) have become more popular in laboratory research for their regenerative healing and menstrual cycling, but we noticed frequent severe wounding in males and females in our colony—likely related to their relatively weak skin. Thus, we recorded the frequency and severity of bite wounding in our colony for one year and found that 46% of spiny mice had at least one bite wound, regardless of sex. The bite wounds in females were less severe, with single wounds on the rump, while males more often had multiple wounds on their anterior and rump. In a separate study, both sexes established stable dominance structures, with most of the fights occurring at the start of the active/dark cycle. Aged animals greater than 22 months old were never observed fighting, and the study on bite wounding suggested they also do not inflict bite wounds. These results have implications for both spiny mouse welfare and experimental results using spiny mice since repeated physical trauma can affect healing and menstrual cycling in mice and humans. Abstract Bite wounds due to aggression in male laboratory mice (Mus musculus) are a major welfare concern, often leading to attrition, chronic activation of the innate immune system, and significant impacts on the experimental results derived from the use of these animals as models. Bite wounding within the home-cage of spiny mice (Acomys cahirinus)—a valuable research model for wound healing and menstruation—is poorly characterized. While we have anecdotally observed frequent bite wounding in Acomys, the frequency of aggression within the home-cage, the severity of the bite wounds, and the types of dominance structures remain unstudied. Here, we report that 46% of Acomys cages in our colony had at least one bite wound over the course of a year and that same-sex pairs fought in the home-cage 10% of the time during their dark/active phase. Both sexes inflicted wounds and frequently engaged in agonistic behaviors, even with stable dominance structures. We found that females inflicted less severe bite wounds in same-sex housing. Also, aged females in same-sex pairs were never observed fighting, and no bite wounds were observed in aged Acomys. These results suggest that we should consider whether bite wounding negatively impacts our experimental results since physical trauma is known to alter menstrual cycling and healing.
Aortic arch shape after arch repair predicts exercise capacity: a multicentre analysis

Abstract Aims Coarctation of the aorta is associated with long-term morbidity including decreased exercise capacity, despite successful repair. In the absence of discrete recoarctation, the haemodynamic mechanism remains unknown. This multicentre study evaluated the relationship between aorta shape, flow, and exercise capacity in patients after arch repair, specifically through the lens of aortic size mismatch and descending aortic (DAo) flow and their association with exercise. Methods and results Cardiac magnetic resonance, cardiopulmonary exercise test, and echocardiogram data within 1 year were analysed from 58 patients (age 28 ± 10 years, 48% male) across four centres with history of isolated arch repair. Aortic arch measurements were correlated with % predicted VO2max with subgroup analyses of those with residual arch obstruction, bicuspid aortic valve, and hypertension. Ascending aorta (AAo) to DAo diameter ratio (DAAo/DDAo) was negatively correlated with % predicted VO2max. %DAo flow positively correlated with VO2max. Sub-analyses demonstrated that the negative correlation of DAAo/DDAo with VO2max was maintained only in patients without arch obstruction and with a bicuspid aortic valve. Smaller aortic arch measurements were associated with both hypertension and exercise-induced hypertension. Conclusion Aorta size mismatch, due to AAo dilation or small DAo, and associated decreased %DAo flow, correlated significantly with decreased exercise capacity after aortic arch repair. These correlations were stronger in patients without arch obstruction and with a bicuspid aortic valve. Aorta size mismatch and %DAo flow capture multiple mechanisms of altered haemodynamics beyond blood pressure gradient or discrete obstruction and can inform the definition of a successful repair.
Role of managerial support in the relationship of psychological resilience with career satisfaction

Today, retaining employees is difficult due to changes in information and communication technologies, increasing competition speed, and other environmental factors. Therefore, organisations’ management daily increases their interest in positive psychology to retain employees and reveal their strengths. One concept that accompanies positive psychology and positive organisational behaviour is resilience (Luthans, 2002). It is known that individuals who are more psychologically resilient can produce positive outcomes by overcoming adverse emotional events (Shirazi, Laei, & Mosavi, 2016). Career satisfaction (CS), another concept of work, appears as a concept that is likely to be affected by changes in organizational structure, mobility, and employee expectations (Kraimer, Greco, Seibert, & Sargent, 2019). However, CS is one of the most important results of the individual’s career success (Hofmans, Dries, & Pepermans, 2008). In this context, this study aims to reveal the role of management support in the relationship between CS and psychological resilience (PR). The data collected from 200 white-collar employees was evaluated using the SPSS Programme and the Hayes Process. As a result of the analysis, it was determined that MS is a moderator in the relationship between PR and CS.
The stratigraphic record and processes of turbidity current transformation across deep‐marine lobes

Sedimentary facies in the distal parts of deep‐marine lobes can diverge significantly from those predicted by classical turbidite models, and sedimentological processes in these environments are poorly understood. This gap may be bridged using outcrop studies and theoretical models. In the Skoorsteenberg Formation (South Africa), a downstream transition from thickly bedded turbidite sandstones to argillaceous, internally layered hybrid beds, is observed. The hybrid beds have a characteristic stratigraphic and spatial distribution, being associated with bed successions which generally coarsen and thicken‐upward reflecting deposition on the fringes of lobes in a dominantly progradational system. Using a detailed characterization of bed types, including grain size, grain‐fabric and mineralogical analyses, a process‐model for flow evolution is developed. This is explored using a numerical suspension capacity model for radially spreading and decelerating turbidity currents. The new model shows how decelerating sediment suspensions can reach a critical suspension capacity threshold beyond which grains are not supported by fluid turbulence. Sand and silt particles, settling together with flocculated clay, may form low yield strength cohesive flows; development of these higher concentration lower boundary layer flows inhibits transfer of turbulent kinetic energy into the upper parts of the flow ultimately resulting in catastrophic loss of turbulence and collapse of the upper part of the flow. Advection distances of the now transitional to laminar flow are relatively long (several kilometres) suggesting relatively slow dewatering (several hours) of the low yield strength flows. The catastrophic loss of turbulence accounts for the presence of such beds in other fine‐grained systems without invoking external controls or large‐scale flow partitioning and also explains the abrupt pinch‐out of all divisions of these sandstones. Estimation of the point of flow transformation is a useful tool in the prediction of heterogeneity distribution in subsurface systems.
Canine oral melanoma with suspected pulmonary metastasis: Combination of immunotherapy and tyrosine kinase inhibitor treatment

This case report follows a 10-year-old castrated male Miniature Schnauzer dog presented with a history of incomplete surgical resection of an oral malignant melanoma (amelanotic type) on the right mandible. Melanoma vaccine therapy was administered due to incomplete surgical resection, however, new masses were detected on the contralateral mandible and suspected pulmonary metastasis occurred at 2 weeks and 7 months, respectively, following the first melanoma vaccination. At the time of detecting the pulmonary metastasis, targeted chemotherapy was initiated with the owner’s consent using imatinib (10 mg/kg/day, p.o.), a tyrosine kinase inhibitor (TKI). The patient did not show any significant adverse events related to both anticancer treatments. Three months following the first dose of imatinib, the absence of the suspected pulmonary metastatic nodules on radiography indicated complete remission. In conclusion, this report describes the achievement of clinical remission of suspected pulmonary metastatic oral malignant melanoma and an extension of survival time in a dog given a combination treatment of immunotherapy and tyrosine kinase inhibitor.
Adherence to Hiv treatment regimens: systematic literature review and meta-analysis

Background: Antiretroviral therapy (ART), when taken consistently, reduces morbidity and mortality associated with human immunodeficiency virus and viral transmission. Suboptimal treatment adherence is associated with regimen complexity and high tablet burden. Single-tablet regimens (STRs) provide a complete treatment regimen in a single tablet. This study examined the relationship between STRs (vs multiple-tablet regimens [MTRs]), treatment adherence, and viral suppression. Methods: A systematic review was conducted to identify studies investigating at least one of the following: (1) STR/MTR use and adherence; (2) levels of adherence and viral suppression; and (3) STR/MTR use and viral suppression. Meta-analysis was performed to assess the relationship between STR vs MTR use and adherence in observational settings at $ 95% and $ 90% adherence thresholds. Results: In total, 29 studies were identified across the three objectives; two studies were relevant for all objectives. STRs were associated with higher treatment adherence than MTRs in 10/11 observational studies: a 63% greater likelihood of achieving $ 95% adherence (95% CI = 1.52–1.74; P , 0.001) and a 43% increase in the likelihood of achieving $ 90% adherence (95% CI = 1.21–1.69; P , 0.001). Higher adherence rates were associated with higher levels of viral suppression in 13/18 studies. Results were mixed in five studies investigating the association between STR or MTR use and viral suppression. Conclusion: Although the direct effect of STRs vs MTRs on viral suppression remains unclear, this study provided a quantitative estimate of the relationship between STRs and ART adherence, demonstrating that STRs are associated with significantly higher ART adherence levels at 95% and 90% thresholds. Findings from the systematic review showed that improved adherence results in an increased likelihood of achieving viral suppression in observational settings. Future research should utilize similar measures for adherence and evaluate viral suppression to improve assessment of the relationship between pill burden, adherence, and viral suppression.
Epicardial Pulsed Field Ablation of Ganglionated Plexi: Computational and Pre-Clinical Evaluation of a Bipolar Sub-Xiphoid Catheter for the Treatment of Atrial Fibrillation

Epicardial pulsed field ablation (PFA) of ganglionated plexi (GPs) is being explored as a potential treatment for atrial fibrillation. Initial work using open-chest access with a monopolar ablation device has been completed. This study describes the early development work for a device that can be used with subxiphoid access and deliver bipolar ablation pulses. Electric field computational models have been used for the initial guidance on pulse parameters. An in vivo assessment of these ablation parameters has been performed in an open-chest canine study, while subxiphoid access and navigation of the device has been demonstrated in a porcine model. Results from this acute study have demonstrated the promising potential of this approach.
The Effect of Application of Low-calorie Sugar on Chemical, Physical, and Organoleptic Characteristics of Red Dragon (Hylocereus polyrhizus) Fruit Syrup

Syrup is a thick sugar solution with or without the addition of permitted food additives. Syrup usually uses high calorie cane sugar which can trigger obesity if it is not balanced by physical activity. This study aimed to determine the effect of low-calorie sugar application on chemical characteristics (including pH, vitamin C, reducing sugars, betacyanin), and physical characteristics (total dissolved solids) and organoleptic (including aroma, taste, color) in red dragon fruit syrup. The experiment was designed following randomized block design (RBD) with one-factor treatment, namely the concentration of sugar consisted of 5 treatments (K1: 3%, K2: 6%, K3: 9%, K4: 12%, K5: 15 %). Each treatment was repeated 5 (five) times to obtain 25 experimental units. The results showed that the application of low-calorie sugar significantly affected the syrup's chemical characteristics, namely reducing sugar. They had a significant effect on the physical characteristics of the syrup, namely the total dissolved solids. However, it did not significantly affect pH, vitamin C, and betacyanin levels. From the organoleptic test, the panelists liked red dragon fruit syrup the most, with a concentration of 15% for each organoleptic parameter, including aroma, taste, and color. Keywords: Low-calorie sugar, Obesity, Organoleptic, Red dragon fruit, Syrup
The new checklist to evaluate educational value of YouTube surgical videos of transurethral resection of the prostate

Background Transurethral resection of the prostate (TURP) is a widespread, effective way to treat benign prostatic hyperplasia (BPH). Many medical students and junior clinicians increasingly turn to easily accessible online resources to learn this technique, such as videos on YouTube. This study assessed the educational value of YouTube videos about TURP, which are popular among many young surgeons. Methods We searched YouTube as of August 2, 2022 for videos fulfilling the search terms “transurethral resection of the prostate”, “benign prostatic hyperplasia”, “BPH”, “TURP”, “benign prostatic enlargement”, “bladder outlet obstruction” and “lower urinary tract symptom”. We assessed the educational value of the identified videos using a custom-designed checklist. Results We identified 47 relevant videos, 20 of which were posted after July 1, 2020. The average number of views was 576,379±208,535 (range, 54–1,385,713). The average quality score of the videos was 7.38±2.53 (range, 4–12) on a 15-point scale, and 20 were judged to be of low educational quality. Quality scores correlated positively with the number of likes (R=0.596, P<0.01). Conclusions The educational value of most TURP videos on YouTube appears to be low, with most lacking detailed explanations of preoperative preparations and the surgical procedure. High-quality video resources about TURP need to be developed for medical students and junior surgeons. Standard quality criteria should also be developed and disseminated to ensure the production of accurate learning resources for junior clinicians.
Refining Line Art From Stroke Style Disentanglement With Diffusion Models

A beginner who wants to create illustrations has difficulty improving his/her ability without expert advice. Especially in the initial steps, line drawings are critical but hard to evaluate because there are many assessment points, such as shape, variation in thickness, stroke fluency, and shadow expression. Moreover, there is no well-summarized line art dataset based on expert knowledge to support skill refinement. Furthermore, the evaluation criterion is always subjective. To solve this problem, we custom-build systematized line artworks formed by cataloged stroke styles and propose a machine learning method that can automatically give clues to refining the artworks. We request 10 professional-level artists to create line art in six patterns; the stroke styles of the images are systematically summarized. Using this specific dataset, we train an auxiliary classifier to identify and remove features of those patterns to refine all line artwork commonly. We also implement an enhancement step that uses diffusion models to add more informative details to the generated results. The proposed method can automatically identify where strokes are needed to change and generate high-quality refined versions. Our method performs better than the previous method regarding L2, lpips, and SSIM scores while giving specialized clues to different stroke styles.
Global patterns and environmental drivers of forest functional composition

To determine the relationships between the functional trait composition of forest communities and environmental gradients across scales and biomes and the role of species relative abundances in these relationships.Global. Recent.Trees. We integrated species abundance records from worldwide forest inventories and associated functional traits (wood density, specific leaf area and seed mass) to obtain a data set of 99,953 to 149,285 plots (depending on the trait) spanning all forested continents. We computed community‐weighted and unweighted means of trait values for each plot and related them to three broad environmental gradients and their interactions (energy availability, precipitation and soil properties) at two scales (global and biomes). Our models explained up to 60% of the variance in trait distribution. At global scale, the energy gradient had the strongest influence on traits. However, within‐biome models revealed different relationships among biomes. Notably, the functional composition of tropical forests was more influenced by precipitation and soil properties than energy availability, whereas temperate forests showed the opposite pattern. Depending on the trait studied, response to gradients was more variable and proportionally weaker in boreal forests. Community unweighted means were better predicted than weighted means for almost all models.Worldwide, trees require a large amount of energy (following latitude) to produce dense wood and seeds, while leaves with large surface to weight ratios are concentrated in temperate forests. However, patterns of functional composition within‐biome differ from global patterns due to biome specificities such as the presence of conifers or unique combinations of climatic and soil properties. We recommend assessing the sensitivity of tree functional traits to environmental changes in their geographic context. Furthermore, at a given site, the distribution of tree functional traits appears to be driven more by species presence than species abundance.