Miracle-dz/UniFAR-FTUs huggingface dataset:
Hubble Space Telescope Observations of the Associated Absorption-Line Systems in Q0122+0338

We have studied a spectrum of Q0122+0338 (ze ~ 1.202) obtained by the Faint Object Spectrograph (FOS) on board the Hubble Space Telescope (HST). We present the analysis of three associated (za ~ ze) absorption systems at z = 1.207, 1.199, and 1.166. The most complex of these, at za ~ 1.207, shows strong absorption from the highly ionized transitions of Lyα, Lyβ, N V, O VI, Si III, Si IV, and possibly P V. We derive (minimal) ionic column densities for this system of N(H I) = 1015.3 cm-2, N(N V) = 1014.8 cm-2, N(O VI) = 1015.4 cm-2, N(Si III) = 1013.3 cm-2, and N(Si IV) = 1013.7 cm-2. By comparing the derived column densities with those predicted from numerical photoionization models, we find that conditions in the absorbing gas are consistent with an absorber with a metallicity ~2 Z☉ and a total absorbing column density of N(H) ≃ 2 × 1019 cm-2. The kinematics of the absorption lines in the za ~ 1.207 system suggests that a correlation exists between the relative velocity and the creation ionization potential energy for each transition. This is evidence that a complex, multicomponent absorber exists. Although the location of the absorber is uncertain (intrinsic vs. intervening), we consider the origin of this absorption system using the available data and discuss how the high ionization and high metallicity indicate that the absorber may be intrinsic to Q0122+0338.
Cardiometabolic Risk and Cardiovascular Disease in Young Women With Uterine Fibroids

Uterine fibroids are associated with hypertension and cardiometabolic risk factors, yet the onset and severity of cardiovascular disease (CVD) in women with fibroids remain understudied. We used data from the National Health and Nutrition Examination Survey to assess the association between uterine fibroids, cardiometabolic risk, and CVD (ischemic heart disease, heart failure, and stroke). Among 5,552 women aged 20-54 years in our sample. Hypertension was more common in those diagnosed with fibroids (n=700; 33.4% vs. 15.3% in controls, p<0.001), but these women were also older (44 (SD=7) years vs. 35 (SD=10) years). When stratified by median age, women aged 35 or younger with fibroids (n=97) were more likely than controls (n=2771) to have hypertension (14.1% vs. 2.4%), obesity (51.5% vs. 32.5%), and diabetes mellitus (4.8% vs. 1.9%). Women older than 35 with fibroids also had higher cardiometabolic risk and rates of CVD than controls (8.5% vs. 4.5%). The odds ratio of CVD in women with fibroids, compared to the controls, was 3.10 with 95% confidence interval (CI) of 2.21 to 4.34. The odds ratio decreased to 1.63 (95%CI: 1.11 to 2.38) after adjusting for age, BMI, African ancestry, fasting plasma glucose, cholesterol, education, smoking history, and postmenopausal status and to 1.60 (95%CI: 1.08 to 2.37) after further adjusting for systolic blood pressure. These data indicate that uterine fibroids are associated with a worse cardiovascular risk profile, including hypertension, in relatively young women, leading to early CVD. A women-specific research agenda is urgently needed to study the nature of these associations and design preventive strategies to prevent cardiovascular events in young women with fibroids.
Turkish Version of the Silencing the Self in School Scale: Validity and Reliability Study for Emerging Adults

The purpose of this study is to adapt the STSIS Scale to Turkish and to investigate its psychometric qualities. The scale comprises 22 items and three variables (self-silencing, divided self, and putting the teacher first). The study participants comprised 298 young adults with a mean age of 21.09 years. Utrecht Work Engagement Scale-Student Form, Negative Affect Schedule, and Perception Form for Life Skills were used to evaluate the scale's criterion validity. The construct validity was investigated using confirmatory factor analysis. In addition, test-retest and internal consistency coefficients were examined to evaluate the scale's reliability. The Turkish version of the scale consisted of three subdimensions related to the Negative Affect Schedule and Perception Form for Life Skills. In addition, reliability values for the scale were satisfactory. The internal consistency coefficient was . 89, the composite reliability was . 97, and the test-retest validity coefficient was . 86. According to these findings, the Turkish version of the STSIS Scale is a valid and reliable tool for use with young adults.
A MegaCam Survey of Outer Halo Satellites. III. Photometric and Structural Parameters

We present structural parameters from a wide-field homogeneous imaging survey of Milky Way satellites carried out with the MegaCam imagers on the 3.6 m Canada–France–Hawaii Telescope and 6.5 m Magellan-Clay telescope. Our survey targets an unbiased sample of “outer halo” satellites (i.e., substructures having galactocentric distances greater than 25 kpc) and includes classical dSph galaxies, ultra-faint dwarfs, and remote globular clusters. We combine deep, panoramic gr imaging for 44 satellites and archival gr imaging for 14 additional objects (primarily obtained with the DECam instrument as part of the Dark Energy Survey) to measure photometric and structural parameters for 58 outer halo satellites. This is the largest and most uniform analysis of Milky Way satellites undertaken to date and represents roughly three-quarters (58/81 ≃ 72%) of all known outer halo satellites. We use a maximum-likelihood method to fit four density laws to each object in our survey: exponential, Plummer, King, and Sérsic models. We systematically examine the isodensity contour maps and color–magnitude diagrams for each of our program objects, present a comparison with previous results, and tabulate our best-fit photometric and structural parameters, including ellipticities, position angles, effective radii, Sérsic indices, absolute magnitudes, and surface brightness measurements. We investigate the distribution of outer halo satellites in the size–magnitude diagram and show that the current sample of outer halo substructures spans a wide range in effective radius, luminosity, and surface brightness, with little evidence for a clean separation into star cluster and galaxy populations at the faintest luminosities and surface brightnesses.
Interleukin-22 Exerts Detrimental Effects on Salivary Gland Integrity and Function

Interleukin-22 (IL-22) affects epithelial tissue function and integrity in a context-dependent manner. IL-22 levels are elevated in salivary glands of Sjögren’s syndrome (SS) patients, but its role in the pathogenesis of this disease remains unclear. The objective of this study is to elucidate the impact of IL-22 on salivary gland tissue integrity and function in murine models. We showed that IL-22 levels in sera and salivary glands increased progressively in female non-obese diabetic (NOD) mice, accompanying the development of SS. Administration of IL-22 to the submandibular glands of NOD mice prior to the disease onset reduced salivary secretion and induced caspase-3 activation in salivary gland tissues, which were accompanied by alterations in multiple genes controlling tissue integrity and inflammation. Similarly, IL-22 administration to submandibular glands of C57BL/6 mice also induced hyposalivation and caspase-3 activation, whereas blockade of endogenous IL-22 in C57BL/6 mice treated with anti-CD3 antibody mitigated hyposalivation and caspase-3 activation. Finally, IL-22 treatment reduced the number of viable C57BL/6 mouse submandibular gland epithelial cells cultured in vitro, indicating a direct impact of this cytokine on these cells. We conclude that IL-22 exerts a detrimental impact on salivary gland tissues.
Orbital loop currents in iron-based superconductors

We show that the stripe spin-density wave state commonly observed in the phase diagrams of the iron-based superconductors necessarily triggers loop currents characterized by charge transfer between different Fe 3d orbitals. This effect is rooted on the glide-plane symmetry of these materials and on the existence of an atomic spin-orbit coupling that couples states at the $X$ and $Y$ points of the 1-Fe Brillouin zone. In the particular case in which the spins are aligned parallel to the magnetic ordering vector direction which is the spin configuration most commonly found in the iron-based superconductors these loop currents involve the $d_{xy}$ orbital and either the $d_{yz}$ orbital (if the spins point along the $y$ axis) or the $d_{xz}$ orbitals (if the spins point along the $x$ axis). We show that the two main manifestations of the orbital loop currents are the emergence of magnetic moments in the pnictide/chalcogen site and an orbital-selective band splitting in the magnetically ordered state, both of which could be detected experimentally. Our results highlight the unique intertwining between orbital and spin degrees of freedom in the iron-based superconductors, and reveal the emergence of an unusual correlated phase that may impact the normal state and superconducting properties of these materials.
Examining the Relationship between Teachers’ Self-Compassion, Forgiveness, and Psychological Resilience

The purpose of this study is to examine the relationship between teachers' self-compassion, forgiveness, and resilience. For this purpose, a total of 410 volunteer teachers, 222 women and 188 men, working in schools affiliated to the Ministry of National Education were reached. In the study, in which the relational screening model was used, the "Personal Information Form," the "Self-Compassion Scale," the "Heartland Forgiveness Scale," and the "Psychological Resilience Scale" were applied to the teachers. Pearson product moment correlation coefficient analysis, independent samples t-test, one-factor analysis of variance (ANOVA), and Kruskal-Wallis H-test were used to analyze the data. According to the data obtained from the study, there is a statistically significant relationship between teachers' self-compassion, forgiveness, and resilience. In addition, it was found that the scores for self-compassion and forgiveness differed significantly depending on the variables of gender and birth order, forgiveness depending on the variable of marital status, self-compassion and psychological resilience depending on the variable of seniority, and psychological resilience depending on the variable of industry. The results of the study were discussed, and suggestions for future studies were presented.
GaBoDS: The Garching-Bonn Deep Survey; IV. Methods for the Image reduction of multi-chip Cameras

We present our image processing system for the reduction of optical imaging data from multi-chip cameras. In the framework of the Garching Bonn Deep Survey (GaBoDS; Schirmer et al. 2003) consisting of about 20 square degrees of high-quality data from WFI@MPG/ESO 2.2m, our group developed an imaging pipeline for the homogeneous and efficient processing of thislarge data set. Having weak gravitational lensing as the main science driver, our algorithms are optimised to produce deep co-added mosaics from individual exposures obtained from empty field observations. However, the modular design of our pipeline allows an easy adaption to different scientific applications. Our system has already been ported to a large variety of optical instruments and its products have been used in various scientific contexts. In this paper we give a thorough description of the algorithms used and a careful evaluation of the accuracies reached. This concerns the removal of the instrumental signature, the astrometric alignment, photometric calibration and the characterisation of final co-added mosaics. In addition we give a more general overview on the image reduction process and comment on observing strategies where they have significant influence on the data quality.
Topology change and nuclear symmetry energy in compact-star matter

We show that the cusp-like structure in the nuclear symmetry energy, a consequence of topology change, visible in the skyrmion lattice description of dense matter is extremely robust. It is present in the Skyrme model -- with the pion field only -- and is left unscathed by massive degrees of freedom such as the vector mesons $\rho$ and $\omega$ and also the scalar meson introduced as a dilaton. It leads to the emergence of parity-doubling at the skyrmion-half-skyrmion transition and impacts on the nuclear symmetry energy "wilderness" landscape, weeding out roughly half of the wilderness. It is shown that a pseudo-conformal sound velocity arises at a precocious density at which the cusp is formed. It is suggested that the topology change, being robust, could impact on the tidal deformability observed in gravity waves
Time-dependent changes in NLRP3 and Nrf2 levels in lipopolysaccharide-induced acute lung injury

Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are severe clinical conditions with a high mortality rate. Nucleotide-binding oligomerization domain (NOD)-like receptor containing pyrin domain 3 (NLRP3) and nuclear factor E2-related factor 2 (Nrf2) have been reported to be associated with ALI. However, the dynamic changes in the levels of these factors in lipopolysaccharide (LPS)-induced lung injury remain unclear. Thus, the present study aimed to determine the LPS-induced activation of immunological cascades, as well as the NLRP3/Nrf2 signaling pathway at different stages of lung injury. For this purpose, mice were divided into six groups as follows: The control, LPS-4 h, LPS-24 h, LPS-48 h, LPS-96 h and LPS-144 h groups. LPS (4 mg/kg) was administered intratracheally to induce lung injury. Flow cytometry was used to determine the changes in macrophages, neutrophils and T-cell subsets in lung tissue, hematoxylin and eosin staining were used to measure the histopathological changes in lung tissues, ELISA was performed to evaluate the levels of cytokines, western blot analysis was used to measure the levels of inflammatory proteins, and reverse transcription-quantitative PCR used to determine the mRNA level of a target gene. Following LPS administration, evident histopathological damage with neutrophil infiltration was observed which peaked at 48 h. The levels of interleukin-1β, keratinocyte-derived chemokine, macrophage inflammatory protein 2 and tumor necrosis factor a were markedly increased in bronchoalveolar lavage fluid and serum from the mice, and these levels peaked at 4 h. Moreover, LPS promoted Toll like receptor-4 expression and reactive oxygen species production, thus activating NLRP3/Nrf2 signaling and pyroptosis. Collectively, the present study demonstrates that LPS triggers multiple inflammatory molecules and immune cells during ALI, which may be closely involved in the irregular redox status, NLRP3/Nrf2 pathway and pyroptosis.
Association of Higher Rates of Type 2 Diabetes (T2DM) Complications with Psychological and Demographic Variables: Results of a Cross-Sectional Study

Introduction The aim of this study was to assess the relationship between the occurrence and number of T2DM complications with sociodemographic (age, sex, habitation, education), clinical (duration of diabetes, HbA1c (%), BMI) and psychological (well-being, sense of influence on the diabetes course, coping styles) variables. Methods A total of 2574 adult patients were assessed using The Sense of Influence on the Diabetes Course Scale, WHO-5 Well-Being Index, and the Brief Method of Evaluating Coping with Disease. Hierarchical Regression Analysis was conducted with number of complications as the dependent variable and three sets of variables entered in sequential steps: (a) sociodemographic; (b) clinical and (c) psychological factors. Logistic regression analysis was used to examine the association of these variables with diabetes complications’ occurrence. Results A higher number of complications and higher odds ratios of occurrence of complications were associated with sociodemographic and clinical variables, poor well-being, low perception of influence on the diabetes course, and an emotion-oriented coping style. The logistic regression indicated that participants with HbA1c >7% (in comparison with HbA1c ≤ 7%) and with high risk of depression (in comparison with no risk of depression) had respectively 68% and 86% higher odds of developing complications. Discussion The number of complications has weak but statistically significant relations with psychological and clinical factors. Conclusion The results support the rationale of including the psychosocial factors in the context of diabetes management.
Identification of a miRNA-based non-invasive predictive biomarker of response to target therapy in BRAF-mutant melanoma

Rationale: Metastatic melanoma is the most aggressive and dangerous form of skin cancer. The introduction of immunotherapy with Immune checkpoint Inhibitors (ICI) and of targeted therapy with BRAF and MEK inhibitors for BRAF mutated melanoma, has greatly improved the clinical outcome of these patients. Nevertheless, response to therapy remains highly variable and the development of drug resistance continues to be a daunting challenge. Within this context there is a need to develop diagnostic tools capable of predicting response or resistance to therapy in order to select the best therapeutic approach. Over the years, accumulating evidence brought to light the role of microRNAs (miRNAs) as disease biomarkers. Methods: In particular, the detection of miRNAs in whole blood or specific blood components such as serum or plasma, allows these molecules to be good candidates for diagnosis, prognosis and for monitoring response to anticancer therapy. In this paper, we evaluated circulating basal levels of 6 previously identified miRNAs in serum samples of 70 BRAF-mutant melanoma patients before starting targeted therapy. Results: Results show that the circulating levels of the oncosuppressor miR-579-3p and of the oncomiR miR-4488 are able to predict progression free survival (PFS) but not overall survival (OS). Most importantly, we observed that the best predictor of disease outcome is represented by the ratio of circulating miR-4488 vs. miR-579-3p (miRatio). Finally, the combination of the Lactate dehydrogenase (LDH) blood levels with the two circulating miRNAs alone or together did not produce any improvement in predicting PFS indicating that miR-579-3p and miR-4488 are independent predictors of PFS as compared to LDH. Conclusions: All together these data underscored the relevance of circulating miRNAs as suitable tools to predict therapy response in melanoma and maybe further developed as companion diagnostics in the clinic.
Authentic Investigation Activities for Reasoning Ratio Concept

"Abstract: The aim of this research is to examine the effect of authentic investigation activities on the reasoning process of ratio concept which has been regarded as the milestone of mathematics and science teaching. In line with this purpose, the research has been carried out with eight 7th grade students attending a public school located in Central Anatolia Region in Turkey. The success levels of these students in mathematics are in a heterogeneous structure ranging from higher and moderate to lower levels. The data of this qualitative study has been collected through authentic investigation activities, researcher logs, and interviews and has been analysed via descriptive techniques. At the end of the study, it has been concluded that the teaching environment containing authentic investigation activities has a positive effect on the reasoning process of students on ratio concept. "
The chemical composition of the oldest nearby open cluster Ruprecht 147

Context. Ruprecht 147 (NGC 6774) is the closest old open cluster, with a distance of less than 300 pc and an age of about 2.5 Gyr. It is therefore well suited for testing stellar evolution models and for obtaining precise and detailed chemical abundance information. Aims. We combined photometric and astrometric information coming from literature and the Gaia mission with very high-resolution optical spectra of stars in different evolutionary stages to derive the cluster distance, age, and detailed chemical composition. Methods. We obtained spectra of six red giants using HARPS-N at the Telescopio Nazionale Galileo (TNG). We also used European Southern Observatory (ESO) archive spectra of 22 main sequence (MS) stars, observed with HARPS at the 3.6 m telescope. The very high resolution (115 000) and the large wavelength coverage (about 380–680 nm) of the twin instruments permitted us to derive atmospheric parameters, metallicity, and detailed chemical abundances of 23 species from all nucleosynthetic channels. We employed both equivalent widths and spectrum synthesis. We also re-derived the cluster distance and age using Gaia parallaxes, proper motions, and photometry in conjunction with the PARSEC stellar evolutionary models. Results. We fully analysed those stars with radial velocity and proper motion/parallax in agreement with the cluster mean values. We also discarded one binary not previously recognised, and six stars near the MS turn-off because of their high rotation velocity. Our final sample consists of 21 stars (six giants and 15 MS stars). We measured metallicity (the cluster average [Fe/H] is +0.08, rms = 0.07) and abundances of light, α, Fe-peak, and neutron-capture elements. The Li abundance follows the expectations, showing a tight relation between temperature and abundance on the MS, at variance with M 67, and we did not detect any Li-rich giant. Conclusions. We confirm that Rup 147 is the oldest nearby open cluster. This makes it very valuable to test detailed features of stellar evolutionary models.
Impact of Nitrogen Application Rate on Tarnished Plant Bug (Heteroptera: Miridae) Populations and Management in Cotton

The tarnished plant bug, Lygus lineolaris (Palisot de Beauvois), is one of the most economically important pests of cotton, Gossypium hirsutum L. , in the mid-southern U.S. Experiments were conducted during 2012 and 2013 to evaluate the effect of nitrogen fertilizer application rate on tarnished plant bug populations and management as well as cotton growth, development, and yield. Fertilizer (N) was applied as a 32% urea ammonium nitrate (UAN) solution at pinhead square at five different application rates: 0, 45, 90, 134, and 179 kg N ha-1. Plots were managed for tarnished plant bug with insecticides using treatment thresholds recommended by the Mississippi State University Extension Service. A corresponding set of plots for each N fertilizer application rate were not treated with insecticides fto determine tarnished plant bug infestation level and subsequent damage. The interaction of N fertilizer application rate and tarnished plant bug management level (treated or not treated) was significant for total number of plant bugs observed during the growing season. Fertilizer N application rate and tarnished plant bug management each had a significant impact on the mean number of plant bugs observed on a weekly basis and cotton lint yield. Fertilizer N application rate had a significant impact on the number of applications required to manage tarnished plant bug populations. This research demonstrated that there was an optimal level of N availability to balance yield and insecticide applications for tarnished plant bug, thus maximizing profits.