Miracle-dz/UniFAR-FTUs huggingface dataset:
Antihypertensive Effect and Safety of a Candesartan/Hydrochlorothiazide Combination in Patients with Uncontrolled Hypertension: A Prospective Multicenter Observational Study （Chikushi Anti –Hypertension Trial –Ecard(R): CHAT– E Study）

Background：Diuretics cause fewer side effects when administered at low doses and exert synergistic antihypertensive activity in combination with other antihypertensive agents. We investigated the ef ficacy and safety of a combination drug containing candesartan（8 mg） and low dose of hydrochlorothiazide（6.25 mg）（candesartan/HCTZ）in daily medical practice. Methods：A prospective, multicenter, observational study was conducted by 263 medical practitioners using our hospital as the core institution. Patients receiving antihypertensive therapy that included an angiotensin II receptor blocker（ARB） who had not achieved the target clinical blood pressure were switched to candesartan/HCTZ. The primary end– point was the changes of blood pressure and pulse rate. Secondary end– points included adverse events, cardiovascular events, and changes of laboratory test results. Results：One hundred sixteen patients（mean age: 69±11 years; 64 men［55％］） were analyzed and 24 patients dropped out. Major adverse events included hypotension in 4 patients and skin rash in 3 patients. At 6 months, the systolic and diastolic blood pressures were reduced by 20±20 mmHg and 9±12 mmHg（both p＜0.0001）, respectively, while the change of pulse rate was minimal. The target blood pressure was achieved at6 months in 33 patients（35％）. Logistic regression analysis revealed that concomitant diabetes mellitus, chronic kidney disease, dyslipidemia, and a higher baseline diastolic blood pressure were significantly related to not achieving the target blood pressure. Conclusions：In patients with hypertension poorly controlled by ARB– based antihypertensive therapy, candesartan/HCTZ showed a rapid and strong antihypertensive effect that was not influenced by associated cardiovascular risk factors. Candesartan/HCTZ is an effective second – line antihypertensive agent.
"A DERMATOGLYPHIC STUDY OF IRANAIAN MUSLIMS PART I: FINGER PATTERNS AND RIDGE-COUNTS "

Finger Patterns and ridge-counts in a random sample of Iranian Muslims consisting of 100 males and 100 females are described. The most common finger patterns found were loops, having a frequency of 54.4% U.L. , 3.4% R.L. in males and 51.2% U.L. and 4.8% R.L in females. The frequencies of arches and whorls in both sexes were 4% and 38.5% respectively. Bimanual and sex differences were indistinct. A Pattern type index of 11.85 and a pattern intensity index of 13.39 were found in both sexes combined. The mean total finger ridge-count observed is 166.54 in males and 160.93 in females. A significant sex difference of mean ridge-count was observed for digit numbers L3, L4, R2 and also for the total finger ridge-count with regard to bimanual difference for digit 2 in males and for digit 3 in females. The interpretation of the noted observations is discussed.
The Effects of Personality, Family Functioning and Perceived Social Support on Suicide: Suicide Risk Among Individuals in Turkish Probation System

Each year, an average of one million people end their lives by suicide. This rate is higher for disadvantaged groups such as the criminal population and substance users. Psychiatric problems and certain social factors increase suicide risk. Although the criminal involved and substance users have been studied in Turkey, research on suicide risk factors are limited. Therefore, the aim of this study is to examine the effects of personality traits, and psychosocial variables such as family functioning, and perceived social support on suicide risk in individuals directed to Turkish probation services. Participants were 403 males, of which 183 were substance users and 220 were criminals. Results, revealed a significant relationship between being single, low income, criminal behavior at an early age, substance use behavior, multiple drug use, and suicide risk. Additionally, personality traits of neuroticism and psychoticism, as well as family members’ interest in each other were found to be best predictive variables of suicide risk R2= 0.551, F (12, 389) = 39.79, p<. 001; Adjusted R2= . 537, and the explained variance ratio was 55%. These results indicate that inclusion of social support factors such as family support, in suicide prevention programs may decrease suicide risk.
Are obese smokers an unintended consequence of higher cigarette taxes

Using data from the Behavioral Risk Factor Surveillance System from 2000 to 2005, I investigate whether recent, historically-large cigarette tax increases led to weight gains among smokers. Since weight gains may not represent reduced health, I investigate possible distributional impacts of taxes on weight. For women, I find evidence of weight gains across the BMI distribution and across all age groups. In particular, I find that higher cigarette taxes simultaneously reduce the fraction of female smokers who are clinically underweight and increase the fraction who are clinically obese. By contrast, estimated gains for male smokers are concentrated in the right-tail of this distribution and are limited to older men. My findings contribute to a growing literature which suggests that offsetting behaviors may mute any aggregate health benefits associated with taxinduced smoking reductions.
Left Main Coronary Artery Interventions

The management of left main coronary artery (LMCA) disease has evolved over the past two decades. Historically, coronary artery bypass grafting (CABG) surgery has been the gold standard for the treatment of LMCA disease. However, with the advancements in percutaneous coronary interventions (PCIs) and stent technology, PCI in select patients has achieved comparable outcomes to CABG. As such, this has led to changes in the American College of Cardiology and European Society of Cardiology guidelines, which recommend that PCI might be an alternative to CABG in select patients. In this review article, we describe the historical perspective and early experience with coronary interventions of LMCA disease, landmark clinical trials and their effect on guidelines, and the role of intravascular imaging in the management of LMCA lesions.
Mortality Pattern in Broilers at Selected Farms in Punjab

The present investigation was undertaken to study the prevalence and mortality pattern in broilers at selected farms. The prevalence of omphalitis was maximum (0.14%) followed by CRD (0.66%), aflatoxicosis (0.41%), colibacillosis (0.39%), IBH (0.29%), coccidiosis (0.16%), aspergillosis (0.14%), HPS (0.14%), gangrenous dermatitis (0.11%), rickets (0.10%), IBD (0.08%) and gout (0.06%). Maximum mortality was recorded in 1–2 weeks age groups and minimum in 6–7 weeks old birds. Aflatoxins were detected in the suspected feed samples. Various managemental problems were responsible for higher disease incidence at the farms. Based on these, various corrective measures were suggested. After adoption of proper managemental practices, a decreased disease incidence was observed in the subsequent flocks.
Integration of computers in teaching of textiles and clothing at tertiary institutions; a case study of Masvingo Teachers' College, Zimbabwe

This article is based on the study that was conducted among tertiary teachers' colleges in Masvingo province in Zimbabwe to examine the challenges of integrating computer as an instructional teaching strategy. The study employed qualitative research methodology with in-depth interviews and observations providing the data elicited from respondents. The key findings of the study showed that lecturers and students held views that computers were not supposed to change everything in the education system but used as part of the existing teaching strategies. It also emerged that lecturers could hardly use most of the computer software such as spreadsheets, PowerPoint, databases and even internet. There was a great shortage of good quality and appropriate computer software at all the colleges for use in practical departments like Textiles and Clothing. It was concluded that lecturers who were supposed to integrate computers were never exposed to a variety of possibilities on the use of computers in teaching. The Ministry of Higher and Tertiary education is recommended to educate lecturers through in-service courses that feature high quality training on the use of computers as an instructional strategy if the goal of computerising the education system is to be achieved. If the challenges of integrating computers revealed and recommendations raised in this research could be implemented by all sectors of the education system, this could positively benefit lecturers, administrators and students to accomplish long standing educational goals such as improving basic literacy and student inquiry.
Sobrevida en cáncer de próstata de una población del centro de Colombia

Background: prostate cancer (PC) occupies the first place of occurrence in the US; in developing countries it is between the fourth and sixth place, except in Brazil where it is the first cancer in men. In the West Oncologists S.A. of Colombia records, it ranks sixth in the general population and is the second malignancy in males. Materials and methods: a follow-up of patients treated in the West Oncologists -headquarters of Caldas- was carried out, with an influence population of 1.1 million inhabitants and a total of 12 000 records analyzed from January 1997 to June 2012, for a final report of 404 patients with prostate cancer. Results: the mean age was 69 years, 73% between 61 and 80 years; 56% in clinical stage II (II-A: 22% and II-B: 34%) and 18% stage IV. Gleason Scale less than 6 in 37%, 33% equal to 7 (4 + 3: 49% and 3 + 4: 51%). 30% with PSA between 4 and 10 ng / mL and 13% greater than 100 ng / mL PSA. 36% with some type of prior treatment (prostatectomy and orchiectomy 17%: 9%); 90% with Karnofsky > 80%; 29% relapsed and 73% of those with biochemical relapse; radiotherapy was performed in 92% (60% directed to the primary tumor and 16% to metastasis); stage T1c was found in 41%. The 10-year survival was 94% between 61 and 70 years (p = 0.001). In patients with Gleason 20 to 99 ng / mL was 78% (p = 0.001). In patients with relapse, ten-year survival was 68% versus 87% in its absence (p <0.01). Mean follow-up was 40.1 months (interquartile range: 16-52). Survival at five and ten years in localized stage was 92% and 79%; in metastatic disease was 52% and 30% respectively and with regional disease survival was 100% in both five and ten years. Conclusion: this paper analyzes prognostic factors recognized in the world literature applied to patients with prostate cancer in our country, regarding the survival of five to ten years, as a point of reference that can help specialists in the therapeutic decisions and could become a motivation for other Colombian institutions to generate similar research projects. (Acta Med Colomb 2015; 40: 101-108).
The Internet Addiction and Related Factors among Students of Yazd Universities

Aim: Nowadays, the Internet is considered as an appropriate means of transferring knowledge in education and research processes. However, overusing the Internet may cause addiction. This problem may increase as the Internet usage increases. This paper attempted to study the Internet addiction among the students of Yazd universities. Methods: This research was a cross-sectional study conducted among 238 students of Yazd University Medical Sciences and 245 students of Yazd Payam-e-Noor University. The data were collected using the Internet Addiction Questionnaire introduced by Young. To analyze data, several statistical operations were conducted, including mean, percentage, Chi-square, Spearman’s correlation coefficient, Chi-two, and linear regression. Findings: Among the addicted students, 51% were from Payam-e-Noor University and 49% were from the University of Medical Sciences. Descriptive statistics also revealed that 51% of the addicted students were female and 67% of them were unmarried. Getting news and using e-mail services were mostly reported the Internet usages. Conclusion: Comparing with the previous studies, the Internet addiction has increased among the students of Yazd universities. This problem needs more concise investigation, and educational and counseling planning to reduce the Internet abuse.
The quality of life and functional ability in patients with ankylosing spondylitis

The quality of life and functional ability in patients with ankylosing spondylitis 99 Background. The main objective of this study is to understand the burden of ankylosing spondylitis (AS), to identify the aspects of health-related quality of life (QoL) in patients with AS and compare them with the control group (CG), to explore the factors influencing the QoL. Methods. 65 patients with AS and 67 CG patients participated in this study matching by age, sex and education. The interview comprised socio-demographic questions, the range of disease duration, number of patients with peripheral arthritis, uveitis, comorbidities. The Bath ankylosing spondylitis functional index (BASFI), the Bath ankylosing spondylitis disease activity index (BASDAI), the Bath ankylosing spondylitis global health index (BASG) have been translated, adapted and used in this study. Finally, both groups were asked to fill in the SF-36 as generic QoL instrument. Disease duration time (6.7 years) in AS group was more than twice shorter than time duration of complaints (16 years). More than one third of the patients had uveitis and more than half of them had arthritis. Results. QoL on all the scales of the SF-36, especially in physical health-related QoL, was significantly worse than in the CG. D isease-specific instruments – BASFI, BASDAI, BASG and pain – were significantly associated with the component of physical and mental health re lated QoL. Conclusion. AS influences the subjective health of the affected person; especially the physical health related QoL. BASFI, BASDAI, BASG and pain are significantly associated with SF-36 physical and mental domains in patients with AS.
Ethnobotanical study of medicinal plants traditionally used in Tana River County for management of illnesses.

Aim of the study: The objective of the study was to identify and document medicinal plants traditionally used by people of Tana River County, Kenya for the management of various ailments. Materials and methods: The study was conducted in March 2012. Information was gathered from 80 traditional practitioners who lived and practiced in Garsen, Itsowe and Ngao Subdivisions of Tana River using semi-structured questionnaires and focused group discussion. Voucher specimen of cited plants were collected and deposited at the university of Nairobi herbarium. Results: A total of 31 plants distributed in 25 families were identified. The most popular plant species were eleven and were used for the management of pneumonia, arthritis, kidney problems, fibroids, typhoid, breast cancer, tooth ache, malaria, diabetis, convulsions, stomach ache, constipation, poisoning, cholera, diarrhea, mastitis, migraine, tonsilitis, ulcers, asthma, high blood pressure, urinary incontinence, body warts, milk letdown and as immune boosters. Conclusion: The use of herbs is still very common amongst Tana River inhabitants and the healers still rely largely on naturally growing plant species in their locality. Furthermore, the documented medicinal plants can be used as a basis for future phytochemical and pharmacological studies.
Phase III randomized study of neoadjuvant chemotherapy (CT) with docetaxel(D), oxaliplatin(O) and S-1(S) (DOS) followed by surgery and adjuvant S-1, vs surgery and adjuvant S-1, for resectable advanced gastric cancer (GC) (PRODIGY)

Abstract Background Adjuvant CT after D2 gastrectomy is standard therapy for resectable advanced GC in Asia. We investigated whether added neoadjuvant (NA) CT can further improve outcomes. Methods 530 pts with newly diagnosed locally advanced gastric or gastroesophageal junction (GEJ) adenocarcinoma (cT2,3/N[+]M0 or cT4/N[any]M0, AJCC 7th ed), ECOG PS 0-1, were randomized 1:1 to NA DOS then surgery and adjuvant S-1 (CSC; n = 266), or surgery and adjuvant S-1 (SC; n = 264). NA CT was D 50mg/m2 iv and O 100mg/m2 iv on day 1, S 40mg/m2 twice po on days 1–14 every 3 weeks for 3 cycles. Standard surgery was D2 gastrectomy. Adjuvant CT was S 40mg/m2 twice po on days 1–28 every 6 weeks for 8 cycles. Primary endpoint: 3-year progression free survival (PFS) in full analysis set (FAS). Results With 46 pts excluded due to ineligibility or consent withdrawal, FAS was 484 pts (238 in CSC, 246 in SC). Baseline characteristics were balanced. In CSC arm, 214 pts (90.0%) completed 3 cycles of NA DOS. Main ≥grade3 toxicities: neutropenia in 12.6%, febrile neutropenia 9.2%, diarrhea in 5.0%, 1 treatment related death. 222 CSC (93.3%) and 246 SC (100%) pts underwent surgery. R0 resection rates: 96.4% vs 85.8%, p Conclusions Addition of NA DOS to D2 gastrectomy and adjuvant S-1 led to significant tumour downstaging and improved PFS with acceptable safety in PRODIGY study. Neoadjuvant DOS chemotherapy followed by D2 gastrectomy and adjuvant S-1 should be considered as a treatment option for resectable advanced GC. Clinical trial identification NCT01515748. Legal entity responsible for the study Sanofi Korea. Funding Sanofi Korea. Disclosure Y. Kang: Advisory / Consultancy: Ono; Advisory / Consultancy: BMS; Advisory / Consultancy: AstraZeneca; Advisory / Consultancy: Merck Serono; Research grant / Funding (institution): Roche; Advisory / Consultancy, Research grant / Funding (institution): Novartis; Advisory / Consultancy: Daehwa; Advisory / Consultancy: LSKBiopharma; Advisory / Consultancy: Taiho; Advisory / Consultancy: Blueprint; Advisory / Consultancy: Macrogenics; Advisory / Consultancy: Zymeworks; Advisory / Consultancy: Hengrui. G. Kim: Shareholder / Stockholder / Stock options, Full / Part-time employment: Sanofi. Y. Lee: Shareholder / Stockholder / Stock options, Full / Part-time employment: Sanofi. All other authors have declared no conflicts of interest.
Upaya Menurunkan Waktu Tunggu Obat Pasien Rawat Jalan dengan Analisis Lean Hospital di Instalasi Farmasi Rawat Jalan RS Atma Jaya

ABSTRAK Salah satu cara untuk melakukan efisiensi, meningkatkan mutu pelayanan dan meningkatkan keselamatan pasien di Amerika dengan menggunakan konsep Lean Thinking yang diterapkan di rumah sakit menjadi Lean Hospital. Di Rumah Sakit Atma Jaya yang merupakan Rumah Sakit Swata Kelas B Pendidikan, penelitian ini menganalisis alur pelayanan resep di Instalasi Farmasi Rawat Jalan sebagai data untuk perbaikan. Dengan menggunakan Root Cause Analysis (RCA), metodologi penelitian operational research, dilakukan observasi dan wawancara mendalam memperlihatkan bahwa kegiatan non value added bisa sampai 85% dan kegiatan value added hanya 15% pada penyiapan obat non racikan. Sedangkan untuk obat racikan kegiatan non value added sekitar 68% dan value added sebesar 32% nilainya. Data tersebut menunjukan bahwa telah terjadi pemborosan ( waste ). Usulan perbaikan untuk mengurangi pemborosan antara lain penggantian SIM RS yang baru dan menggiatkan fungsi Tim Kendali Mutu di Instalasi Farmasi. Bila perbaikan ini telah di implementasi, diharapakan terjadi peningkatan efisiensi di Instalasi Farmasi Rawat Jalan dan meningkatkan kepuasan pasien. ABSTRACT One option to increase efficiency, service quality and patient safety in the United States of America is by using the Lean Thinking concept, which are implemented in Hospitals to become a Lean Hospital. In Atma Jaya Hospital, a class B study private hospital, the research analyses the workflow of prescription sevice in outpatient pharmacy departement to act as data for improvement analysis. Also, by utilizing Root Cause Analysis (RCA), operational research methology, in-depth observation and interviews are conducted at compounding and non-compounding medicine storage of Outpatient Patient Departement, the result shows non-value added activities reaches 85%, while value added activities are only 15% on non-compounding medicine storage. While, on compounding medicine storage, non-value added and value added activities are at 68% and 32% respectively. These data clearly shows that great inefficiencies has occurred. Solution is suggested to increase the efficiency in the department, changing Hospital Information System and activate the Quality Control Team function. If these steps are implemented, we can expect the overall efficiency in the Outpatient Pharmacy Departement to improve significantly and resulted in higher patient satisfaction. concepts lean, lean thinking, lean hospital, prescription, drug waiting time, outpatient, waste, Root Cause Analysis.
Effects of the heavy usage of kava on physical health: summary of a pilot survey in an Aboriginal community

Health status was assessed in 39 kava users and 34 non‐users in a coastal Aboriginal community in Arnhem Land. Twenty (27%) respondents were very heavy (mean consumption, 440 g/week) users of kava; 15 (21%) respondents were heavy (310 g/week) users of kava and four (5%) respondents were occasional (100 g/week) users of kava. Kava users were more likely to complain of poor health and a “puffy” face, and were more likely to have a typical scaly rash, and slightly‐increased patellar reflexes. Very heavy users of kava were 20% underweight and their levels of γ‐glutamyl transferase were increased greatly. Albumin, plasma protein, urea and bilirubin levels were decreased in kava users, and high‐density lipoprotein cholesterol levels were increased. Kava users were more likely to show haematuria, and to have urine which was poorly acidified and of low specific gravity. The use of kava was also associated with an increased red‐cell volume, with a decreased platelet volume and with a decreased lymphocyte count. Shortness of breath in kava users was associated with tall P waves on a resting electrocardiogram, which provided suggestive evidence of pulmonary hypertension. In common with other Aboriginal communities, there was evidence of decreased lung volumes, a high carriage rate of hepatitis B surface antigen, and of other morbidity that was unrelated to the use of kava. On the basis of these findings, there is a strong rationale for urgent social action to improve health in Aboriginal communities and, in particular, to reduce the consumption of kava and to improve the nutritional status of kava users.
Using Patient Profiles To Guide The Choice Of Antihistamines In The Primary Care Setting In Malaysia: Expert Consensus And Recommendations

Abstract H1-antihistamines are recognized to be effective for conditions such as allergic rhinitis and chronic spontaneous urticaria. However, management of such conditions in the real-world primary care setting may be challenging due to diverse patient-specific considerations, the wide range of antihistamines available, choice of other treatment modalities, and the complexity of interpreting specialist treatment algorithms. Despite regular updates to international guidelines, regional/national surveys of healthcare professionals show a clear gap between guidelines and real-world practice, particularly at the primary care level. This article thus presents the consensus opinion of experts from relevant specialties in Malaysia – allergology, pediatrics, otorhinolaryngology, and dermtology – on harmonizing the use and choice of antihistamines in primary care. Patient profiling is recommended as a tool to guide primary care practitioners in prescribing the appropriate antihistamine for each patient. Patient profiling is a three-step approach that involves 1) identifying the individual’s needs; 2) reviewing patient-specific considerations; and 3) monitoring treatment response and referral to specialists in more severe or difficult-to-treat cases. Concurrently, guidelct 3ines should be reviewed and updated periodically to include recommendations that are easily actionable for primary care practitioners.