Miracle-dz/UniFAR-FTUs huggingface dataset:
Presentations Related to Acute Paracetamol Intoxication in an Urban Emergency Department in Switzerland

Aim To investigate the characteristics of Emergency Department (ED) presentations due to acute paracetamol intoxication. Methods Retrospective observational study of patients presenting to the ED of Bern University Hospital between May 1, 2012, and October 31, 2018, due to a paracetamol overdose (defined as intake of >4 g/24 h). Cases were identified using the full-text search of the electronic patient database and were grouped into intentional (suicidal/parasuicidal) and unintentional intoxications (e.g., patient unaware of maximal daily dose). Results During the study period, 181 cases were included and 143 (79%) of those were intentional. Compared to the patients in the unintentional group, patients in the intentional group were more often female (85% vs 45%, p < 0.001) and younger (median age 23.0 vs 43.5 years, p < 0.001), more frequently suffered from psychiatric comorbidities (93%, (including 49% with borderline personality disorder) vs 24%, p < 0.001), and paracetamol was more often taken as a single dose (80% vs 13%, p < 0.001). Although the median daily ingested dose was lower in the unintentional than in the intentional group (8.2 g vs 12.9 g, p < 0.001), patients in the unintentional group presented later (29% vs 84% within 24 h of ingestion, p < 0.001), included more cases of acute liver failure (nine (24%) vs six (4%), p < 0.001), and were more often hospitalised (24% vs 52% treated as outpatients, p=0.002). There were no significant differences between the groups regarding drug-induced liver injury (seven cases (5%) in the intentional and one (3%) in the unintentional group) or fatalities (one in each group). Conclusions The majority of presentations due to paracetamol poisoning were intentional, most commonly in female patients with borderline personality disorder. Patients with unintentional paracetamol intoxication had worse outcomes with respect to acute liver failure and hospitalisation. Future preventive measures should raise awareness of paracetamol toxicity in the general population and encourage particular attention and frequent follow-ups when prescribing paracetamol for vulnerable groups.
Investigating the Impact of Anthropogenic and Natural Sources of Pollution on Quality of Water in Upper Indus Basin (UIB) by Using Multivariate Statistical Analysis

Water quality of the Indus River around the upper basin and the main river was evaluated with the help of statistical analysis. In order to analyze the similarities and dissimilarities for identifying the spatial variations in water quality of the Indus River and sources of contamination, multivariate statistical analysis, i.e., principle component analysis (PCA), cluster analysis, and descriptive analysis, was done. Data of 8 physicochemical quality parameters from 64 sampling stations belonging to 6 regions (labeled as M1, M2, M3, M4, M5, and M6) were used for analysis. The parameters used for assessing the water quality were pH, dissolved oxygen (DO), oxygen reducing potential (ORP), electrical conductivity (EC), total dissolved solids (TDS), salinity (%), and concentration of arsenic (As) and lead (Pb), respectively. PCA assisted in extracting and recognizing the responsible variation factors of water quality over the region, and the results showed three underlying factors including anthropogenic source pollution along with runoff due to rain and soil erosion were responsible for explaining the 93.87% of total variance. The parameters which were significantly influenced by anthropogenic impact are DO, EC, TDS (negative), and concentration of Pb (positive), while the concentration of As, % salinity, and ORP are affected by erosion and runoff due to rain. The worst pollution situation for regions M1 and M6 was due to the concentration of As which was approximately 400 μg/l (i.e., 40 times higher than minimum WHO recommendation). Furthermore, the results also indicated that, in the Indus River, three monitoring stations and five quality parameters are sufficient to have a reasonable confidence about the quality of water in this most important reserve of Pakistan.
The COMPARISON OF SHARIA BANKING PERFORMANCE BASED ON RISK PROFILE AND EARNING AND CAPITAL (REC)

This study aims to describe the performance of Islamic banking REC method better or equal to the performance of Islamic banks. Descriptive method isused to find how ratio of Non Performing Loans and Loan to Deposit Ratio representing Risk Profile, Earning representing Return on Assets and Capital ratio representing Capital Adequacy Ratio in Islamic banking for the period 2014-2017. The Independent sample t-test hypothesis test results show that, at th eaverage value of theNPL, FDR and CAR is in significant differences between 11 Islamic banks in Indonesia.Where as ROA has a very significant difference between one bank and an other from 11 Islamic banking in Indonesia.
A review on eye movement analysis in map reading process: the status of the last decade

Eye tracking constitutes a valuable tool for the examination of human visual behavior since it provides objective measurements related to the performed visual strategies during the observation of any type of visual stimuli. Over the last decade, eye movement analysis contributed substantially to the better understanding of how visual attention processes work in different types of maps. Considering the clear need for the examination of map user reaction during the observation of realistic cartographic products (i.e. static maps, animated maps, interactive and multimedia maps), a critical amount of experimental studies were performed in order to study different aspects related to map reading process by the cartographic community. The foundation of these studies is based on theories and models that have been developed in similar research domains (i.e. psychology, neuroscience etc.), while the research outcomes that produced over these years can be used directly for the design of more effective and efficient maps. The aim of the present article is to summarize and present the current panorama of the existing eye tracking studies in cartographic research appeared over the last decade. Additionally, methodological contributions (including analysis tools) of cartographic society in the field of eye movement analysis are reported, while existing challenges and future perspectives are also discussed.
Bacteriological and Histopathological Studies on Adult Shrimps (Penaeus Japonicas) Infected With Vibrio Species in Suez Canal Area

210 shell diseased shrimps (Penaeus japonicas) were collected and taken alive from port-said governorate. Shell diseased shrimps were taken monthly from January to October 2016 and subjected to clinical, postmortem, bacteriological and histopathological examinations. In addition of 15 apparently healthy shrimps, free from any shell lesions were collected and taken alive from port-said Governorate were used in the experimental infection (pathogenicity test). Results revealed that the isolated bacteria from shell diseased shrimps were identified as Vibrio alginolyticus and Vibrio parahemolyticus. The number of isolates for Vibrio alginolyticus was 568 isolates by incidence of 77.59%, Vibrio parahemolyticus was 131 isolates by incidence of 17.89%, It was found that Vibrio alginolyticus, Vibrio parahaemolyticus, were highly isolated from the muscles by ratio of 95.71%, the cuticle by ratio of 90% then from gills by ratio of 80% followed by the hemolymph by ratio of 51.90%, while it was less isolated from the hepatopancrease by ratio of 30.95%. The pathogenicity test of the isolated microorganisms showed nearly the same clinical picture and postmortem findings which observed in naturally infected shrimps and isolated vibrio speciesappear to be highly virulent gave 100% mortality in 60 hrs. of the experimental infected shrimps. Vibrio alginolyticus and Vibrio parahemolyticus were sensitive to Norofloxacin, Ciprofloxacin and Trimethoprim-Sulfamethoxazole and resistant to Amikacin and Rifamycin. The histopathological studies among naturally infected shrimps (penaeus japonicas) revealed changes in muscles, gills and hepatopancrease due to infection as intermuscular edema, inflammatory cells between muscle bundles and degeneration and necrosis of muscles, the gills showed squamous metaplasia, and the hepatopancreas showed congestion in the hepatic vessels, advanced vacuolar degeneration with nuclear pyknosis of most hepatocytes were evident.
SILVER NANOPARTICLES INDUCED MULTIPLE ORGAN TOXICITY IN MICE

ABSTRACT Background: Silver nanoparticles (AgNPs) are considered one of the most commonly used nanoparticles due to its broad antimicrobial activity. However, the toxic effects of nanoparticles on normal cells and living organs are still not fully determined. Objectives: the present study was designed to investigate the toxicity of silver nanoparticles on liver, kidneys, brain and spleen in mice and to explore the possible mechanisms behind it. Material and Methods: 16 male mice from local strain were randomly classified into (1) control group (2) silver nanoparticles treated group; mice were orally administered AgNPs (1mg/kg/day) for 28 days. Biochemical analysis for serum levels of liver transaminases, urea and creatinine, lipid peroxides, reduced glutathione, superoxide dismutase, total antioxidant capacity and TNF-α were done in addition to histopathological examination for the four organs. Results: silver nanoparticles treated group showed significantly elevated serum levels of liver transaminases, urea and creatinine together with significant high levels of lipid peroxides and TNF-α with significant decrease in serum levels of reduced glutathione, superoxide dismutase and total antioxidant capacity. Histopathology of the organs revealed tissue damages in AgNPs treated group evidenced by disturbed organ architecture, congestion, increased inflammatory cells with signs of necrosis. Conclusion: administration of silver nanoparticles produced remarkable toxic effects to the liver, kidneys, brain and spleen of mice, probably via activation of oxidative stress and inflammatory processes in these organs.
Improving ESP Students` Reading Comprehension throu gh Multimedia Techniques: The Case of Power Point

Recent studies suggest that the use of multimedia h as lways been a field of inquiry for practitioners and teachers in the field of second l anguage learning. With the emergence of technological equipment, teaching practices has bec ome more effective in learning experiences and PowerPoint as multimedia in which both words an d relevant graphics are used simultaneously can be a good example in this case. Th present study tries to investigate the effect of using PowerPoint as a multimedia presenta tion on improving ESP for architectural University students` reading comprehension. To this end, 90 homogenous University students majoring in Architecture whose syllabus mostly focu ses on reading comprehension are selected based on an OPT test. The participants are divided to two experimental groups and a control group. Data analysis through conducting a One-Way A NOVA reveals that applying PowerPoint on reading comprehension courses for ESP students f acilitates their level of comprehension. The results of the study show that the experimental gro up`s scores on posttest which receives reading comprehension texts through PowerPoint are signific antly different from the control group. The findings of the study will shed lights on the impro vement of the ability of reading comprehension of ESP courses in which learners are encouraged to read extensively on the related issues to keep themselves as updated as possible to the world knowledge.
Effect of Internationalisation on Balanced Scorecard among Malaysian Small and Medium Enterprises

The purpose of this paper is to identify the relationships between dimensions of internationalisation on balanced scorecard (BSC), among Malaysian small and medium enterprises (SMEs). Internationalisation covers the dimensions of knowledge, trust and commitment. Internationalisation can benefit the firm performance of SMEs in Malaysia which is measured using balanced scorecard, by increasing the involvement of SMEs in international business. A sample of 404 data was considered as the final sample size for this study. By using Structural Equation Modelling (SEM), the dimensions of internationalisation were observed to test the hypotheses. The results indicate that internationalisation as a whole does not have a role in the results of BSC among Malaysian SMEs. However, this also indicates that internationalisation is useful to reach the firm performance mostly in larger organisations because they require more strategic internationalisation to be more triumphant over their rivals which the larger organisations have. Furthermore, most SMEs in Malaysia are relatively new and being mostly family enterprises, these SMEs in Malaysia are more knowledgeable to perform domestic business. Therefore, this research conveys an understanding to the owners and managers to quickly achieve BSC results. Finally, this study brings some conclusions to the policy makers and regulators as well
Effects of Selenium and Melatonin on Ocular Ischemic Syndrome

Purpose To determine the effects of selenium, melatonin, and selenium + melatonin administered for one month on anterior chamber (AC) malondialdehyde (MDA) and AC glutathione (GSH) levels in patients with ocular ischemic syndrome. Materials and Methods Thirty-five patients were included in the study. Study groups were formed as follows: (1) control group, (2) ischemia group, (3) selenium + ischemia group, (4) melatonin + ischemia group, and (5) selenium + melatonin + ischemia group. AC samples were obtained. MDA and GSH levels in AC samples were evaluated. Results MDA levels were significantly increased in ischemia groups. Selenium and melatonin supplementation resulted in reduction of MDA levels and significant increase in GSH values. Discussion Increased lipid peroxidation associated with ischemia of the anterior segment has been prevented by selenium and melatonin supplementation. This trial is registered with ClinicalTrials.gov NCT04005222.
ARCHITECTURE AND CULTURAL HERITAGE MANAGEMENT TOOLS: LANDSCAPE ACTION PLANS

In our southern European environment, planning continues to be addressed with 19th-century zoning instruments and defined policies. The growing reaction to the impositions of this territorial policy in local areas proposes a strong bottom-up, non-urbanism of the strategic and the punctual, whose results are beginning to be insufficient due to their limited continuity and difficult coordination. The work in network and with articulated and inter-connectable projects, is revealed, however, as a tool of utility not yet sufficiently tested. To overcome the barrier between what we define as “planning” or macroterritorial policy and “ordination” at a micro level, tools such as Landscape Action Plans (LAP) are proposed. The LAP is structured as a document that, starting from the micro analysis of all facets of the landscape (not only of how it is perceived, but also of its identity generating dimension, and even of its socio-economic aspects), and listening to the demands of the citizens through social dialogue processes, raise a solution to shared problems in local or municipal areas. This solution must be defined not only formally, but applying the determinations emanated from the regional policy of Territorial Planning designed for larger areas. In the last six years, the design of LAP by our Constructed Heritage Research Group (GPAC) has yielded very interesting results in terms of coordinating municipal and regional policies, such as the Landscape Action Plans of Trapagaran (2016) and Ortuella (2018), among others. The planning of small, embraced landscapes, endowed with strong character, through Landscape Action Plans (LAP), could be an option to channel this desire for local planning into a network, which compensates or inspires a broader and more democratic territorial policy.
An Efficient Scalable Hybrid Proposed MAC Protocol for M2M Networks

Machine to Machine (M2M) refers to the technology that allows the devices to communicate autonomously with other devices over the wired or wireless systems. Neither the contention based Medium Access Control (MAC) protocols nor the reservation based MAC protocols can provide a flexible, scalable solution for M2M networks that contain a large number of the devices. In this paper, a proposed hybrid MAC protocol for M2M network will be suggested which combines the main features of two different protocols. It composes of three main parts: Notification Period, Contention Period, and Transmission Period. Different devices contend on the transmission opportunities with the same contending probability during the Contention Period based on Non-persistent Carrier Sense Multiple Access (NP-CSMA) mechanism. During the transmission period, only the successful devices will reserve a time slots to transmit its data packet based on Time Division Multiple Access (TDMA) reservation based mechanism. Moreover, the proposed protocol performance can be measured in terms of three metrics: throughput, average delay time, and Packet Delivery Ratio. Extensive MATLAB programs are done to present a comparison between the Proposed Protocol with other conventional protocols.
Efficient Variable Thickness Radome Design with Insertion Phase Delay Correction

Variable thickness design is capable of yielding excellent electromagnetic (EM) performance for streamlined airborne radomes. The traditional optimization method using evolutionary computation (EC) techniques can yield variable thickness radome (VTR) design with optimal EM performance but uncontrollable thickness profile, leading to manufacturing difficulties. Thickness profile design based on average incident angle is an efficient way for VTR design with smooth thickness profile, whereas the boresight error (BSE) is relatively large. In this work, insertion phase delay (IPD) correction is introduced in the efficient thickness profile design process to realize a better balance between EM performance and thickness profile smoothness of airborne radomes. The thickness profile obtained from average incident angle is adjusted for IPD distribution symmetry with respect to the antenna axis under scan angles with large BSE. Results indicate that the proposed method can effectively improve the BSE characteristics at the expense of slight deterioration of computational efficiency and thickness profile smoothness.
Effect of Tool Kinematics on Tube Flanging by Extrusion with a Moving Sleeve

This paper presents the results of a numerical investigation into tube flanging by extrusion with a moving sleeve. Two cases of the extrusion process are investigated, each described with a different tool kinematics. Effects of flange diameter, gap height and tool motion on the extrusion process are examined. The numerical analysis is performed on 42CrMo4 steel tubes deformed at ambient temperature. Obtained numerical results are then used to determine metal flow patterns and examine force parameters in the extrusion process, as well as to determine a technological window for the investigated method.
Effect of different levels of citric acid as supplementation on growth performance, feed utilization, body composition, water quality, and blood profile of Monosex Male Nile Tilapia (Oreocheromis niloticus) fingerlings

Over the last 20 years, aquaculture is growing more rapidly than all other animal food production sectors (FAO, 2016). The expansion of aquaculture production has been accompanied by the rapid growth of aquafeed production. Aquaculture is the fastest-growing animal food-producing sector in the world, whose potential to meet the challenges of food security, and generate jobs and economic gains have been clearly demonstrated (FAO, 2016). Therefore, it is essential to find ways to develop the activity in a sustainable way, seeking to increase production without compromising natural resources, based on a vision of food and nutritional security (Hlpe, 2014). Nutrition is one of the most important factors influencing the ability of cultured tilapia to exhibit its genetic potential for growth and it is greatly influenced ARTICLE INFO ABSTRACT Article History: Received: July,15,2019 Accepted:Aug, 23,2019 Online: Aug, 30, 2019 _______________
In vitro models of the blood brain-barrier using iPSC-derived cells

The blood-brain barrier (BBB) constitutes the interface between the blood and the brain tissue. Its primary function is to maintain the tightly controlled microenvironment of the brain. Models of the BBB are useful for studying the development and maintenance of the BBB as well as diseases affecting it. Furthermore, BBB models are important tools in drug development and support the evaluation of the brain-penetrating properties of novel drug molecules. Currently used in vitro models of the BBB include immortalized brain endothelial cell lines and primary brain endothelial cells of human and animal origin. Unfortunately, these cell lines and primary cells have failed to recreate physiologically relevant control of transport in vitro. Human-induced pluripotent stem cell (iPSC)-derived brain endothelial cells have proven a promising alternative source of brain endothelial-like cells that replicate tight cell layers with low para-cellular permeability. Given the possibility to generate large amounts of iPSC-derived brain endothelial cells they are a feasible alternative when modelling the BBB in vitro. This thesis aimed to develop iPSC-derived models of the BBB that display a barrier like phenotype and characterize these models in terms of specific properties. The BBB model development was based on investigations into mechanisms important for barrier formation in iPSC-derived endothelial cells and development of high-quality supporting cells. The possibilities to use the model in drug discovery, and in determination of brain penetrating capacity of drug substances were specifically considered. These studies have increased knowledge of molecular mechanisms behind the restricted permeability across iPSC-derived endothelial cells and identified transcriptional changes that occur in iPSC-derived endothelial cells upon coculture with relevant cell types of the neurovascular unit. Furthermore, high quality iPSC-
Will Professional Accountants Whistleblow on Organizational Fraud ?

PwC reported that in 2014 nearly one in five organizations (eighteen percent) experienced fraud that had an impact of between one million dollars and $100 million (Crumbley et al., 2017, 3–2). The answers to reversing the trend could include prevention and detection. Prevention involves implementation of internal controls and the monitoring of those controls to reduce opportunities of fraud. Fraud detection involves proactively searching for fraud. This study focuses on one method that has been effective in the detection of fraud: whistleblowing.