Miracle-dz/UniFAR-FTUs huggingface dataset:
Novel PANK2 mutation identified in patient with pantothenate kinase-associated neurodegeneration

Introduction. Pantothenate kinase-associated neurodegeneration (PKAN) is a rare, recessively inherited disorder caused by mutations in the pantothenate kinase 2 (PANK2) gene on chromosome 20p13. The objective of this report is to present a patient with atypical PKAN with the novel heterozygous PANK2 mutation. Case outline. We present a 32-year-old female who had disease onset at the age 20 (depression, speech, chewing problems and backward falls) with progressive course. Neurological examination revealed hypomimia, risus sardonicus, dysphagia, tachylalia and severe dystonic dysarthria, moderate arms, legs, and jaw-opening dystonia, postural instability, urge incontinence, and decreased visual acuity. Brain magnetic resonance imaging revealed iron accumulation in the bilateral globus pallidus and putamen (“eye-of-the-tiger”), a radiological finding pathognomonic for PKAN. Genetic analysis revealed known mutation p.T528M (c.1583C>T) in exon 6, and novel p.Y405D (c.1213T>G) in exon 3 of the PANK2 gene. In silico analyses strongly suggested this mutation to be pathogenic. Conclusion. We report a patient with PKAN, and novel substitution p.Y405D (c.1213T>G) in PANK2 that has not been previously described in PKAN patients.
Management of tillering in the production of flower stems of heliconia cultivated in pots

Potted cultivation of tropical flowers presents good projections for the northeastern region of Brazil; however, it still faces some peculiarities regarding conduction and management. The objective of this study was to evaluate the effect of tillering on the production of Heliconia psittacorum L.f. cv. Red Opal, grown in flowerpot. The experiment was carried out in a protected environment at the Campus of Agricultural Sciences (CCA) of UNIVASF, Petrolina - PE, Brazil, between 2014 and 2016. A completely randomized design was used, with four tiller densities per pot (4, 8, 12 and 16 tillers) and eight replications, totaling 32 plots. The irrigation system was automated and monitored by weighing lysimetry. Were evaluated: efficiency of water use (EUA); harvested flower stems (HC); ratio of harvested stems and number of tillers (HC / NP); number of leaves (NF); duration of vegetative (DFV) and productive phases (DFP); total cycle (CT); floral stem length (CHF); floral stem diameter (DH), bracts length (CB) and equivalent diameter of the collar (DECH). The results were subjected to regression test. The EUA was higher in the density of 16 tillers pot-1; the HC variable presented an increasing linear trend; a decreasing linear trend was detected for HC/NP, NF, DFP, DH, CB and DECH. The number of tillers in the pot does not limit the emission of floral stems. However, the quality of these is inversely proportional to the tiller density.
Challenging workplace inequality: precarious workers' institutional and associational power in Gauteng, South Africa

Abstract:The world of work has been reorganised, the numbers of workers employed through the standard employment relationship has declined and there has been an increase in non-standard employment: labour broking, outsourcing and other forms of precarious and temporary work. This has created highly unequal workplaces where atypical workers perform the same work as permanent workers for often half the wages of what a permanent worker receives. This article considers how precarious workers are organising, outside of trade unions, to fight against workplace inequality to gain rights to permanent work. This article develops the power resource approach (PRA) as a lens through which to explore how labour broker workers are organising in Gauteng. Through the analysis of two workplace case studies, the article examines how amendments to the Labour Relations Act (LRA) in 2015 provided new rights and a new avenue through which precarious workers could organise. The case studies illustrate the dynamic interactions between institutional and associational power, an often overlooked relationship , and demonstrate the multiple avenues through which precarious workers mobilise their power to fight against inequality.
Ecological Stoichiometery and Consumer-Driven Nutrient Recycling by Elliptio complanata (Lightfoot) in a Northeastern Coastal Zone Pond

Abstract Freshwater mussels recycle nutrients within their environment, and the extent of their influence depends on ambient nutrient concentrations and time of year. This study investigated the stoichiometry of consumer-driven nutrient recycling (C, N, and P) of the numerically dominant indigenous freshwater mussel Elliptio complanata (Eastern Elliptio) in a New England pond, which we accomplished by evaluating the stoichiometry of seston, mussel tissues, excretion, and biodeposition. Based on our results, we identified 4 major findings. First, we found seston CNP was not variable across seasons as expected, with only 4 of 10 pairwise interactions being statistically significant, and did not necessarily match the Redfield ratio as expected with higher C:N and lower C:P and N:P observations. Second, we found our tissue CNP to be below the expected 106:16:1 Redfield ratio and that the mussels did not adhere to strict stoichiometric homeostasis throughout different sizes/ages, as shown with 5 of 12 regressions being statistically significant. Third, we found freshwater mussel excretion to be similar to that found in other studies and that excretion rates and ratios were influenced by size and shifted with changes in season—possibly related to seston composition as well as environmental conditions such as temperature, based on 7 of 10 statistical analyzes being significant. Finally, we found freshwater mussel biodeposition to be variable across time for nutrient rates and ratios as we expected.
Surface Quality and Free Energy Evaluation of s275 Steel by Shot Blasting, Abrasive Water Jet Texturing and Laser Surface Texturing

Surface modification by different technologies prior to joining operations or improving tribological properties is a point of great interest. Improving surface activation by increasing the roughness of the metal is a relationship that is becoming more defined. In turn, an increase in surface wettability by evaluating contact angles indicates surface activation by obtaining a high surface free energy. Technologies such as shot blasting and laser surface texturing (LST) have generated several scientific studies where they have identified the influence of parameters on the formation of rough surfaces with defined patterns. However, the application of abrasive water jet texturing (AWJT) has been little studied as an alternative. This article compares these technologies in the texturing of a carbon steel s275 in order to identify the relationship between surface quality and surface activation. It has been determined that AWJT produces the highest Rt values close to 64 µm with a cross feed of 0.45 mm and a traverse speed of 5000 mm/min. Furthermore, LST obtains the best values of free surface energy by combining a power of 20 W with a frequency of 20 kHz and a sweeping speed of 10 mm/s. Finally, contour diagrams have been obtained which relate these variables to the texturing parameters.
Bayesian statistical inference for intractable likelihood models

Dans un processus d’inference statistique, lorsque le calcul de la fonction de vraisemblance associee aux donnees observees n’est pas possible, il est necessaire de recourir a des approximations. C’est un cas que l’on rencontre tres frequemment dans certains champs d’application, notamment pour des modeles de genetique des populations. Face a cette difficulte, nous nous interessons aux methodes de calcul bayesien approche (ABC, Approximate Bayesian Computation) qui se basent uniquement sur la simulation de donnees, qui sont ensuite resumees et comparees aux donnees observees. Ces comparaisons necessitent le choix judicieux d’une distance, d’un seuil de similarite et d’un ensemble de resumes statistiques pertinents et de faible dimension.Dans un contexte d’inference de parametres, nous proposons une approche melant des simulations ABC et les methodes d’apprentissage automatique que sont les forets aleatoires. Nous utilisons diverses strategies pour approximer des quantites a posteriori d’interets sur les parametres. Notre proposition permet d’eviter les problemes de reglage lies a l’ABC, tout en fournissant de bons resultats ainsi que des outils d’interpretation pour les praticiens. Nous introduisons de plus des mesures d’erreurs de prediction a posteriori (c’est-a-dire conditionnellement a la donnee observee d’interet) calculees grâce aux forets. Pour des problemes de choix de modeles, nous presentons une strategie basee sur des groupements de modeles qui permet, en genetique des populations, de determiner dans un scenario evolutif les evenements plus ou moins bien identifies le constituant. Toutes ces approches sont implementees dans la bibliotheque R abcrf. Par ailleurs, nous explorons des manieres de construire des forets aleatoires dites locales, qui prennent en compte l’observation a predire lors de leur phase d’entrainement pour fournir une meilleure prediction. Enfin, nous presentons deux etudes de cas ayant beneficie de nos developpements, portant sur la reconstruction de l’histoire evolutive de population pygmees, ainsi que de deux sous-especes du criquet pelerin Schistocerca gregaria.
A Relationship between Spiritual Intelligence and Psychological Capital with Academic Performance among Students in Kashan University of Medical Sciences in 2016

Background and objectives: Spiritual intelligence and psychological capital are an approach that help ones to adapt with environment, health, performance and creativity. Therefore, the purpose of this research was analysis of relationship between spiritual intelligence and psychological capital academic performance among students in Kashan University of Medical Sciences. Martials and methods: The type of research was correlative descriptive. The statistical population consisted of students of Kashan University of Medical Sciences that 294 students were selected by stratified random sampling. The data collection tool was a spiritual intelligence questionnaire in 40 items and a psychological capital inventory questionnaire in 24 items with five degrees Likert scale. The validity of the contents of tools was verified. Reliability was estimated by Cronbach's alpha coefficient for spiritual intelligence 0.82 and psychological capital of 0.91. Data analysis was done at descriptive and inferential level using SPSS software version 22. Results: The findings showed that means of spiritual intelligence components (3.20±0.50) and psychological capital (3.51±0.41) were higher than average (3). Also there are significant and positive relation between spiritual intelligence with academic performance (r=0.25) and psychological capital with academic performance (r=0.19). Conclusion: According to the findings, spiritual intelligence and higher psychological capital were associated with better academic performance. By improving the dimensions of spiritual intelligence and psychological capital, it is possible to improve the academic performance of students.
Delay- and Interference-Aware Routing for Wireless Mesh Network

Effective routing design can significantly improve the whole network performance. In order to achieve the global best network performance, the problem of routing can be formulated as a constrained optimization problem. A delay- and interference-aware routing (DIAR) method using optimization is proposed in this article to find effective routes in a wireless mesh network. With the rapid development of wireless communication, next-generation networks urge shorter delay. DIAR aims at selecting routes with minimum end-to-end delay for several concurrent data flows. Delay is derived according to interference, bandwidth, and the probability of transmission failure. Then, the relationship between delay and the number of interfering nodes is built for the first time, which makes the estimation of delay more simple. When solving the optimization problem, an improved genetic algorithm is proposed to balance load. Besides, DIAR considers dynamic network condition caused by selecting different paths to transmit packets and evaluates the network condition while finding the solution of routing. The paths with least end-to-end delay will be finally chosen as the solution. Simulation results show that DIAR can obtain better network performance.
Seroprevalence of Rheumatoid Factor in Arthritis Cases in a Teritiary Care Hospital

Rheumatoid arthritis is a chronic, severe, progressive inflammatory autoimmune disease of uncertain etiology involving multiple peripheral joints 1 . Rheumatoid arthritis can also produce diffuse inflammation in the lungs, pericardium, pleura, sclera and also nodular lesions most common in the subcutaneous tissue. About 1% of the world population is afflicted by rheumatoid arthritis and is more common in women than in men and generally occurs between the ages of 40 and 60 years. The disease onset is usually gradual with the predominant symptom being pain, morning stiffness and swelling of many joints 2 . Tends to affect smaller joints of hand and feet early and later on as the disease progresses, symptoms often spread to the knees, ankles, elbows, hips and shoulders. 3,4
Active constraints for robotic surgery in deforming tissue

Active constraints are collaborative human-robot control algorithms which have a well-established history of use within robot assisted surgery research. This control strategy anisotropically regulates the motion of a human user in such a way that it effectively combines the competencies of surgeons and robots, allowing for improved clinical outcomes and surgeon experience. The significant majority of research previously presented for active constraints focuses on their application to static procedures, where the surgical environment is assumed to be rigid throughout. In this thesis, several research contributions are presented which assist with applying active constraints in surgical procedures within deforming soft tissue. The primary contribution is the formulation of a novel haptic control algorithm, based on friction, which can effectively guide a surgeon in both positioning and orienting a surgical instrument, while guaranteeing that the haptic interaction is energetically dissipative. The proven dissipative formulation of these ‘dynamic frictional constraints’ ensures that the surgeon always has overall control of a procedure and makes the system resilient to limitations and errors in the robot’s comprehension of the surgical environment. To apply active constraints within deforming tissue, it is necessary to compute the geometric relationship between the surgical instruments and the constrained anatomy. A novel bounding volume is proposed which, when used in a hierarchy, exploits the limits of soft tissue deformations to increase the resolution of constraint geometries that can be used at stable control rates. The experimental validation of these research contributions in a clinically realistic nerve dissection simulation and in non-clinical dynamic path-following tasks, shows significant benefits to the user in several metrics characterising surgical accuracy and precision. These results demonstrate that the proposed enhancements of active constraints could lead to increased surgeon performance, fewer complications and improved clinical outcomes in soft tissue surgical procedures.
PENGARUH DIVERSITAS DEWAN DIREKSI TERHADAP NILAI PERUSAHAAN

The establishment of a company has a clear purpose. The company's goal is to achieve maximum profits and prosper the owner of the company or the shareholders (stockholders). One of the reasons why companies in Indonesia are vulnerable to economic turmoil is the weak implementation of good corporate governance. Good Corporate Governance (GCG) is basically a concept that concerns the company's structure, division of tasks, division of authority, division of responsibilities of each element of the company structure. The purpose of this study is to determine the influence of the female board of directors, the age of the board of directors, educational background of the board of directors, and the board of directors of foreign nationality towards the value of the company in LQ45 companies listed on the Indonesia Stock Exchange in the period 2015-2017. The research method used in this study is a hypothesis test that is to analyze the influence of the female board of directors, the age of the board of directors, the educational background of the board of directors, and the foreign board of directors of corporate value. Based on the data obtained, the results of the educational background variables of the Board of Directors and foreign board of directors influence the value of the company, while the variable of the board of directors of women and the age of the board of directors do not affect the value of the company. Keywords: Gender, Age, Education, Nationality, Firm Value
HUBUNGAN PARITAS DAN ANEMIA DENGAN KEJADIAN INERSIA UTERI PADA IBU BERSALIN DI RSUD PROF. dr. MARGONO SOEKARJO PURWOKERTO TAHUN 2011

Inersia uteri adalah salah satu kelainan tenaga (kelainan his) karena memanjangnya fase laten atau fase aktif atau kedua-duanya dari kala pembukaan. Inersia uteri pada ibu bersalin dapat disebabkan oleh beberapa factor antara lain faktor umum seperti umur, paritas, anemia, ketidaktepatan penggunaan analgetik, pengaruh hormonal karena kekurangan prostaglandin atau oksitosin , perasaan tegang dan emosional. Mengetahui hubungan antara paritas dan anemia dengan kejadianinersia uteri pada ibu bersalin di RSUD Prof. dr. Margono Soekarjo Purwokerto tahun 2011. Penelitian ini merupakan penelitian survey analitik dengan rancangan case control . Jenis data yang digunakan pada penelitian ini adalah data sekunder dan intrumen penelitiannya menggunakan lembar observasi. Populasi penelitian adalah semua ibu bersalin dengan inersia uteri dan ibu bersalin normal periode 1 Januari 2011 sampai 31 Desember 2011. Sampel kasus dan sampel control masing-masing sebanyak 75 orang. Metode analisa data menggunakan uji Chi Square. Paritas ibu bersalin sebagian besar pada kategori tidak berisiko sebanyak 134 orang (89,3%), anemia pada ibu bersalin sebagian besar pada kategori normal sebanyak 89 orang (59,3%), ada hubungan paritas ibu bersalindengan kejadian inersia uteri ( p = 0,017; OR = 5,032; phi = 0,194), ada hubungan anemia ibu bersalin dengan kejadian inersia uteri ( p = 0,046; OR = 2,069; phi = 0,162). Ada hubungan antara paritas dan anemia dengan kejadian inersia uteri di RSUD Prof. dr. Margono Soekarjo Purwokerto tahun 2011. Ibu Hamil hendaknya menjaga kesehatan kehamilannya dengan melakukan pemeriksaan ANC secara rutin, mengecek Hb untuk mencegah anemia pada kehamilan, mengkonsumsi FeSO4, sayuran hijau, ibu hamil mengetahui bahwa melahirkan dengan jarak terlalu dekat dapat mengakibatkan masalah persalinan. Kata Kunci : paritas, anemia dan inersia uteri
A Justification of the Probabilistic Explanation of the Entropy Principle

In many ways, entropy and probability are two concepts that complement each other. But it has been argued that there is no ‘straightforward connection’ between them with a no-go thesis from Kevin Davey. However, this skeptical conclusion rests on counterexamples that fail to do justice to the entropy principle and the equivocality of the notion of probability. Proceeding from the disambiguation of probability, and acknowledging the explanatory goal of the entropy principle, it is argued that the Boltzmannian statistical mechanics account can be vindicated with a justification of the explanandum, the reference class, and the standard uniform probability measure.
Interdisciplinary management of an orthodontic patient with temporomandibular disorder

A 21-year-old female patient presented with temporomandibular disorder, skeletal Class II, Angle Class II division 2 malocclusion, gummy smile, and incomplete overbite was managed successfully by splint therapy and orthodontic camouflage with miniscrew anchorage and extraction. She was treated with occlusal splint to alleviate signs and symptoms of anterior disc displacement without reduction and the associated masticatory dysfunction and revealed the true malocclusion before orthodontic treatment. Computer software facilitated the formulation of visual treatment objective (VTO) and occlusogram which guided the whole arch intrusion, retraction of the upper anterior segment, mesialization of lower left dentition, and distalization of lower right dentition. In this case report, the rationale and importance of preorthodontic splint therapy and specific considerations in orthodontic mechanics for managing this patient were discussed.
Investigación y Educación en Enfermería

Perception of the informed consent form by participants in clinical trials Objective. To understand the perception of the participants in controlled clinical trials (CCTs) about the informed consent and describe the meaning of their participation in the research. Methodology. Qualitative study using the focus group technique. The sample was composed of 19 patients who participated in clinical trials about hypertension and coronary disease in a specialized cardiologic hospital located in the city of Sao Paulo. The methodological framework used was the content analysis. Results. Some of the participants were aware of the real objective of these studies while others had misperceptions. The reading of the informed consent is not always done and, when it is done, the patient does not understand it. The lack of understanding about the term " placebo " was mentioned by some participants. The motivation to participate was the personal benefit. Conclusion. This study shows that obtaining the informed consent in CCTs is complex and that there is the need to adapt the structure and application of this document, in order to protect the participants and improve the quality of clinical trials performed in the country. Perception of the informed consent form by participants in clinical trials Article linked to research: Assessment of how research participants understand their participation in clinical trials. investigações clínicas realizadas no país.
Clinical significance of minimal residual disease (MRD) quantification in dogs with lymphoma

報告番号: 甲26965 ; 学位授与年月日: 2011-03-24 ; 学位の種別: 課程博士 ; 学位の種類: 博士(獣医学) ; 学位記番号: 博農第3718号 ; 研究科・専攻: 農学生命科学研究科獣医学専攻
Using Vignettes to Assess Gendered Responses to Strain: The Role of Negative State Emotion in Predicting Male vs. Female Intentions to Offend

Abstract This study examines Broidy and Agnew’s propositions that gender disparity in crime may be due to (1) male and females’ experience of distinct emotional reactions to strain and (2) male and females’ response to these emotional reactions with distinct levels of offending. Using a vignette study design with measures spanning a broad range of state emotions and conditioning variables, this study adds to the range of emotion and conditioning variables currently considered in the GST literature, providing a particularly robust test of GST. As expected, results indicate females experience more complex emotional responses to strain, and males are more likely to respond to equivalent types of state negative emotion with intentions to offend. Differences in criminal propensities are largely explained by variables outlined as important GST moderators. Variations by vignette and emotion reveal a more complex relationship between gender, emotion and offending than previously demonstrated.
Long-term Survival Rates for Patients with Aortic Aneurysm

www.lipid. or.kr Original Article J Lipid Atheroscler 2017 June;6(1):22-28 https://doi.org/10.12997/jla.2017. 6.1. 22 pISSN 2287-2892 • eISSN 2288-2561 JLA Long-term Survival Rates for Patients with Aortic Aneurysm Shin Yi Jang, Duk-Kyung Kim Division of Cardiology, Department of Medicine, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea