Miracle-dz/UniFAR-FTUs huggingface dataset:
Dynamics of functions meromorphic outside a small set

The theory of Fatou and Julia is extended to include the dynamics of functions f which are meromorphic in \widehat{\mathbb{C}} outside a totally disconnected compact set E(f) at whose points the cluster set of f is \widehat{\mathbb{C}}. The Julia set is defined not only by the standard approach but is also characterized in terms of the set of points whose orbits approach a point of E(f). For the subclass where E(f) has a complement of class OAD and the inverse of f has a finite set of singular points it is shown that neither wandering components nor Baker domains occur in F(f)>. As an application, functions of a certain general class are shown to have a totally disconnected Julia set.
Long‐pulsed neodymium‐doped yttrium aluminum garnet for hair reduction in pediatric microtia repair

Microtia is the term for congenital malformation of the ear in which the external and internal ear are absent or malformed. Surgical reconstruction is a common management approach and occasionally requires hair reduction of the newly constructed auricle. Few studies have investigated lasers for this purpose. We conducted a retrospective chart review of patients seen at a single institution between 2012 and 2021 who underwent laser hair reduction with long‐pulsed neodymium‐doped yttrium aluminum garnet laser (Nd:YAG). Efficacy ratings were done through review of clinical photographs. Twelve patients were identified with 14 total ears treated. The number of laser treatments varied from 1 to 9 sessions with an average of 5.1 treatments. The majority (8/12) had an “excellent” or “very good” response, one patient had a “good” response, and three were lost to follow‐up. Other than pain, there were no side effects documented. Nd:YAG laser was both effective and safe in our pediatric cohort, without any cutaneous side effects in patients with darker skin.
Life-course fertility and multimorbidity among middle-aged and elderly women in China: Evidence from China health and retirement longitudinal study

Background Multimorbidity has become an important public health problem in China, especially among middle-aged and elderly women. Few studies have been reported on the association between multimorbidity and female fertility, which is an important stage in the life course. This study aimed to explore the association between multimorbidity and fertility history among middle-aged and elderly women in China. Methods Data from 10,182 middle-aged and elderly female participants in the China Health and Retirement Longitudinal Study (CHARLS) in 2018 were used in this study. Multimorbidity was defined as the presence of at least two or more chronic conditions. Logistic regression analysis, negative binomial regression analysis, and restrictive cubic splines (RCSs) were used to analyze the relationship between female fertility history and multimorbidity or the number of chronic conditions. Multivariable linear regression was used to analyze the relationship between female fertility history and multimorbidity pattern factor scores. Results The results of this study showed that high parity and early childbearing were significantly associated with an increased risk of multimorbidity and an increased number of chronic conditions among middle-aged and elderly women in China. Late childbearing was significantly associated with reduced risk of multimorbidity and lessened diseases. Parity and age of first childbirth were significantly correlated with the odds of multimorbidity. The association between fertility history and multimorbidity was found to be influenced by age and urban–rural dual structure. Women with high parity tend to have higher factor scores of cardiac-metabolic, visceral-arthritic, and respiratory-psychiatric patterns. Women with early childbearing tended to have higher factor scores of the visceral-arthritic pattern and those with late childbearing tended to have lower factor scores of the cardiac-metabolic pattern. Conclusion Fertility history has a significant effect on multimorbidity in the middle and later lives of Chinese women. This study is of great importance for reducing the prevalence of multimorbidity among Chinese women through their life course and promoting health during their middle and later lives.
Pathophysiology and Treatment of Functional Paralysis: Insight from Transcranial Magnetic Stimulation

Functional paralysis (FP) or limb weakness is a common presentation of functional movement disorders (FMD), accounting for 18.1% of the clinical manifestations of FMD. The pathophysiology of FP is not known, but imaging studies have identified changes in structural and functional connectivity in multiple brain networks. It has been proposed that noninvasive brain stimulation techniques may be used to understand the pathophysiology of FP and may represent a possible therapeutic option. In this paper, we reviewed transcranial magnetic stimulation studies on functional paralysis, focusing on their pathophysiological and therapeutical implications. Overall, there is general agreement on the integrity of corticospinal pathways in FP, while conflicting results have been found about the net excitability of the primary motor cortex and its excitatory/inhibitory circuitry in resting conditions. The possible involvement of spinal cord circuits remains an under-investigated area. Repetitive transcranial magnetic stimulation appears to have a potential role as a safe and viable option for the treatment of functional paralysis, but more studies are needed to investigate optimal stimulation parameters and clarify its role in the context of other therapeutical options.
Physiological Features of Olympic-Distance Amateur Triathletes, as Well as Their Associations with Performance in Women and Men: A Cross–Sectional Study

The purpose of this study was to verify the physiological and anthropometric determinants of triathlon performance in female and male athletes. This study included 40 triathletes (20 male and 20 female). Dual-energy X-ray absorptiometry (DEXA) was used to assess body composition, and an incremental cardiopulmonary test was used to assess physiological variables. A questionnaire about physical training habits was also completed by the athletes. Athletes competed in the Olympic-distance triathlon race. For the female group, the total race time can be predicted by V̇O2max (β = −131, t = −6.61, p < 0.001), lean mass (β = −61.4, t = −2.66, p = 0.018), and triathlon experience (β = −886.1, t = −3.01, p = 0.009) (r2 = 0.825, p < 0.05). For the male group, the total race time can be predicted by maximal aerobic speed (β = −294.1, t = −2.89, p = 0.010) and percentage of body fat (β = 53.6, t = 2.20, p = 0.042) (r2 = 0.578, p < 0.05). The variables that can predict the performance of men are not the same as those that can predict the triathlon performance of women. These data can help athletes and coaches develop performance-enhancing strategies.
The association between social support and resilience of young adults of Kashmir exposed to stressful events of armed conflicts and with their background variables

ABSTRACT The current study examined the association of social support and background variables with resilience among young adults exposed to traumatic and stressful events of armed conflict in Kashmir, India. Data were collected from 693 participants using a multi-stage sampling method. Findings revealed that social support and gender were positively associated with resilience, whereas education, income, and maternal education were negatively associated with resilience. Moreover, feeling insecure and psychologically distressed as a result of conflict was negatively associated with resilience, whereas, perception that Kashmir conflict will be resolved was positively associated with resilience. The findings suggest fostering of resilience in this population.
Early-stage anaplastic lymphoma kinase (ALK)-positive lung cancer: a narrative review

Background and Objective While anaplastic lymphoma kinase (ALK) tyrosine kinase inhibitors (TKIs) are standard of care treatment for metastatic ALK-positive non-small cell lung cancer (NSCLC), the benefit of moving ALK inhibitors to earlier disease stages is unclear. The objective of this review is to summarize the literature regarding the prevalence and prognosis of early-stage ALK-positive NSCLC and the utility of targeted therapies, immunotherapy, and chemotherapy in the neoadjuvant and adjuvant settings. Methods We identified the references for this narrative review through a literature search of papers about early stage ALK-positive NSCLC using PubMed and clinicaltrials.gov. Last search was run on July 3, 2022. There were no language or time frame restrictions. Key Content and Findings The incidence of oncogenic ALK alterations in early-stage NSCLC ranges from 2–7%, and ALK-positive NSCLC patients are more likely to be younger and never or light smokers. Studies on the prognostic impact of ALK in early-stage disease have had conflicting results. ALK TKIs are not approved in the neoadjuvant or adjuvant setting and there is a lack of large, randomized trial results. Several trials are currently accruing but results are not expected for several years. Conclusions Attempts at large, randomized trials to evaluate the benefit of ALK TKIs in the adjuvant and neoadjuvant has been hampered by slow recruitment given the rarity of ALK alterations, lack of universal genetic testing, and the rapid pace of drug development. Expanded lung cancer screening recommendations, liberalization of surrogate endpoints (i.e., pathological complete response and major pathological response), growth of multicenter national clinical trials, and new diagnostic technologies (i.e., cell-free DNA liquid biopsies) provide hope of generating much needed data to definitively answer the question of the utility of ALK-directed therapies in the early-stage setting.
Thoracic Vertebral Length-to-Height Ratio, a Promising Parameter to Predict the Vertebral Heart Score in Normal Welsh Corgi Pembroke Dogs

Simple Summary The vertebral heart score (VHS) is the most frequent technique for evaluating the canine cardiac size on thoracic radiographs. However, VHS values are varied among dog breeds, possibly due to the characteristics of the thoracic vertebrae. The characteristics of the thoracic vertebrae and the range of the VHS value of the healthy Welsh Corgi Pembroke (Corgis) have never been reported. Therefore, the current study aimed to explore the characteristics of the thoracic vertebrae of the Corgi in comparison with other small-to-medium breed dogs. Among the dog breeds, the characteristics observed through the ratio between the vertebral length and height were different, and the rank of these ratios among the breeds was correlated to the rank of the previously published VHS values. Comparing among the dog breeds, the characteristics of the Corgi’s thoracic vertebrae were more elongated in shape, and the Corgi-specific VHS was significantly lower than the original reported value. Therefore, the characteristics of the thoracic vertebrae might be one of the main factors affecting the normal VHS values among different dog breeds. Abstract The vertebral heart score (VHS) is the sum of the ratio of the cardiac dimensions to the number of thoracic vertebrae, starting from the fourth thoracic vertebra (T4) to the intervertebral disk space (IVS). Breed-specific VHSs, in most cases, were different from the original reference value. Characteristics of the thoracic vertebrae and IVS may influence this variation. This study was conducted to investigate the characteristics of the T4 and IVS on the thoracic radiographs of Corgis in comparison with other small-to-medium breed dogs to evaluate the Corgi-specific VHSs in healthy dogs. The ratio of the T4’s length/height (T4L/H) was significantly different among dog breeds but not the IVS between the T4 and T5. The T4L/H was highest in the Shih Tzu and lowest in Beagle dogs. The Corgi-specific VHS obtained from the ventrodorsal radiograph was significantly higher than that from the dorsoventral radiograph, but a significant difference was not observed between the right and left lateral radiographs. In contrast, the Corgi-specific VHS derived from the right lateral thoracic radiograph was significantly lower than the reference value. This may be correlated with the characteristics of the thoracic vertebrae of Corgis, which were slightly higher than those of the other breeds.
Molecular Clouds and Infrared Stellar Clusters in the Far Outer Galaxy

We present a study of the molecular cloud content and star formation activity in the far outer Galaxy at Galactocentric radii greater than 13.5 kpc. The properties of star-forming regions associated with far outer Galaxy clouds are examined within a 60 deg2 area toward the second Galactic quadrant based on the FCRAO CO Survey of the Outer Galaxy, the IRAS Point Source Catalog, and follow-up 13CO(J = 1-0) and K′-band near-infrared imaging. This region contains 63 far outer Galaxy molecular clouds; the most massive clouds have molecular masses of ~104 M☉. The K′-band imaging of 10 IRAS point sources associated with the far outer Galaxy clouds resulted in the detection of 11 stellar clusters with Galactocentric distances between 13.5 and 17.3 kpc. Several of these clusters are comparable to the well-studied clusters found within 1 kpc of the Sun in terms of the number of stars. We have also examined a much larger sample of far outer Galaxy molecular clouds using the entire FCRAO CO survey. The mass spectrum of 246 far outer Galaxy clouds found within a 300 deg2 area has a power-law slope of -1.88, similar to, although slightly steeper than that found for molecular clouds inside the solar circle. Global measures of the star formation activity, as traced by the ratio of far-infrared luminosity to molecular cloud mass, indicate that these far outer Galaxy clouds are equally active sites of massive star formation as molecular clouds associated with the W3/W4/W5 region and clouds found in the inner Galaxy. Therefore, despite the different environment expected in the far outer Galaxy, the cloud mass spectrum and star formation activity per unit mass are similar to that found throughout the Galaxy. Finally, based on Two Micron All Sky Survey data, we identify 31 additional candidate far outer Galaxy star-forming regions within the larger survey area.
Horizontal Gene Transfer and Fusion Spread Carotenogenesis Among Diverse Heterotrophic Protists

Abstract Thraustochytrids (phylum: Labyrinthulomycota) are nonphotosynthetic marine protists. Some thraustochytrids have crtIBY, a trifunctional fusion gene encoding a protein capable of β-carotene biosynthesis from geranylgeranyl pyrophosphate. Here we show that crtIBY is essential in, and encodes the sole pathway for, carotenoid biosynthesis in the thraustochytrid Aurantiochytrium limacinum ATCC MYA-1381. We explore the evolutionary origins of CrtIBY and discover that the closest related protein domains are present in a small but diverse group of other heterotrophic protists, including the apusomonad Thecamonas trahens and the dinoflagellates Oxyrrhis marina and Noctiluca scintillans. Each organism within this cluster also contains one or more β-carotene 15-15′ oxygenase genes (blh and rpe65), suggesting that the acquisition of β-carotene biosynthesis genes may have been related to the production of retinal. Our findings support a novel origin of eukaryotic (apo)carotenoid biosynthesis by horizontal gene transfer from Actinobacteria, Bacteroidetes, and/or Archaea. This reveals a remarkable case of parallel evolution of eukaryotic (apo)carotenogenesis in divergent protistan lineages by repeated gene transfers.
Real-World Experience With Collagenase Clostridium Histolyticum-aaes for Buttock and Thigh Cellulite: Focus on Administration and Safety Profile

Abstract Background Collagenase clostridium histolyticum-aaes (CCH-aaes) is approved for the treatment of moderate-to-severe buttock cellulite in adult women. Objectives To report on real-world experience with CCH-aaes in the treatment of buttock and thigh cellulite. Methods Retrospective analysis of medical records from a single treatment center. Results The population comprised 28 consecutively treated women; mean age was 40.5 years (range, 23-56 years) and mean body mass index was 25.9 kg/m2 (range, 19.6-41.0 kg/m2). Treatment areas were buttocks only (78.6% of patients), thighs only (10.7%), or both buttocks and thighs (10.7%). Most patients (89.3%) were treated in 2 areas (buttocks or thighs) at each visit; however, 3 patients were treated in 4 areas. At each session, the CCH-aaes dose was 0.07 mg per dimple (0.3 mL of 0.23 mg/mL for buttock cellulite; 1.5 mL of 0.046 mg/mL for thigh cellulite). The mean number of treatment sessions was 2.6 (range, 1-4) for buttock cellulite and 2.5 (range 1-3) for thigh cellulite. The mean number of dimples treated was 11.5 (range, 3-17) per buttock, 11.0 (range, 1-14) per thigh, and 23.4 (range, 8-32) overall per treatment session. Injection site–related adverse events of special interest were experienced by all 28 patients: bruising (100%), edema (96.4%), tenderness (85.7%), nodules (39.3%), pruritus (32.1%), and hyperpigmentation indicative of hemosiderin staining (7.1%). Mean duration of injection-site bruising was 8.8 days (range, 2-15 days). Conclusions CCH-aaes is an effective, well-tolerated, minimally invasive treatment option for buttock and thigh cellulite in women. Level of Evidence: 3
Resistance of a grooved surface to parallel flow and cross-flow

A study is undertaken of both parallel flow and cross-flow in the viscous sublayer generated by a fluid streaming along a grooved surface, with the aim of clarifying the phenomena that underlie the reduction of turbulent drag by such surfaces. A quantitative characterization of the effectiveness of different groove profiles in retarding secondary cross-flow is given in terms of the difference of two ‘protrusion heights’. Analytical calculations of limit cases and a boundary-element computer code for the analysis of general profiles are illustrated, and several examples are presented and discussed.
Medicinal plants as a source of antiparasitics: an overview of experimental studies

ABSTRACT Despite advances in modern human and veterinary medicine, gastrointestinal (GI) parasitic infections remain a significant health issue worldwide, mainly in developing countries. Increasing evidence of the multi-drug resistance of these parasites and the side effects of currently available synthetic drugs have led to increased research on alternative medicines to treat parasitic infections. The exploration of potential botanical antiparasitics, which are inexpensive and abundant, may be a promising alternative in this context. This study summarizes the in vitro/in vivo antiparasitic efficacy of different medicinal plants and their components against GI parasites. Published literature from 1990–2020 was retrieved from Google Scholar, Web of Science, PubMed and Scopus. A total of 68 plant species belonging to 32 families have been evaluated as antiparasitic agents against GI parasites worldwide. The majority of studies (70%) were conducted in vitro. Most plants were from the Fabaceae family (53%, n = 18). Methanol (37%, n = 35) was the most used solvent. Leaf (22%, n = 16) was the most used plant part, followed by seed and rhizome (each 12%, n = 9). These studies suggest that herbal medicines hold a great scope for new drug discoveries against parasitic diseases and that the derivatives of these plants are useful structures for drug synthesis and bioactivity optimization.
Breast Cancer Beliefs and Screening Practices among Syrian Refugee Women and Jordanian Women

Despite significant declines in breast cancer (BC) incidence in the West, this disease is widespread in Jordan, where cancer detection occurs at much advanced stages. This is particularly concerning for Syrian refugee women resettled in Jordan, who are less likely to undergo cancer preventative procedures because of poor health literacy and lack of health services access. The present work assesses and compares breast cancer awareness and breast cancer screening behaviors among Syrian refugee women and Jordanian women residing close to the Syrian–Jordanian border city of Ar-Ramtha. A cross-sectional survey was conducted using a validated Arabic version of the Breast Cancer Screening Beliefs Questionnaire (BCSBQ). A total of 138 Syrian refugee women and 160 Jordanian women participated in the study. Results indicate that 93.6% of Syrian refugee women and Jordanian women ≥ 40 years of age reported never having undergone a mammogram. Syrian refugee women and Jordanian women reported low attitudes toward general health checkup (mean score for Syrian refugees 45.6 vs. 42.04 among Jordan women; p = 0.150). Barriers for BC screening were higher among Syrian refugees (mean score = 56.43) than Jordanian women (mean score = 61.99, p = 0.006). Women with higher education were more likely to report fewer barriers to screening (p = 0.027). The study documents a significant lack of BC screening awareness among Syrian refugee women and Jordanian women, indicating that future work is needed to alter current attitudes towards mammograms and early detection measures especially for Syrian refugee women and Jordanian women residing in rural areas of Jordan.
DETERMINANTS OF THE INTENTION TO USE A NATURAL GAS VEHICLE ( NGV ) AS AN ALTERNATIVE TO A PETROL CAR : THE CASE OF MALAYSIA

The debate regarding the relationship between carbon dioxide emission by vehicles and the impact of emissions on global warming has attracted increasing attention in recent years because of climatic changes worldwide. The average global temperature has risen since the mid 20th century, and it is likely to increase because of man-made greenhouse gas emission. The Intergovernmental Panel on Climate Change (IPCC) has commented that the concentration of greenhouse gases has exceeded the pre-industrial value since 1750, and carbon dioxide (CO2) contents were the highest of the greenhouse gases (Baird & House, 2009). Although the debate on global warming has generated much literature in both developed and developing countries, the majority of the previous studies has concentrated in developed countries and very few have focused on developing countries. However, the recent global financial crisis and the associated spiraling oil prices are placing a great strain on economies in the developing world. In response, governments in developing countries have tended to develop sustainable energy conservation policies.
The Role of NS1 Protein in the Diagnosis of Flavivirus Infections

Nonstructural protein 1 (NS1) is a glycoprotein among the flavivirus genus. It is found in both membrane-associated and soluble secreted forms, has an essential role in viral replication, and modulates the host immune response. NS1 is secreted from infected cells within hours after viral infection, and thus immunodetection of NS1 can be used for early serum diagnosis of dengue fever infections instead of real-time (RT)-PCR. This method is fast, simple, and affordable, and its availability could provide an easy point-of-care testing solution for developing countries. Early studies show that detecting NS1 in cerebrospinal fluid (CSF) samples is possible and can improve the surveillance of patients with dengue-associated neurological diseases. NS1 can be detected postmortem in tissue specimens. It can also be identified using noninvasive methods in urine, saliva, and dried blood spots, extending the availability and effective detection period. Recently, an enzyme-linked immunosorbent assay (ELISA) assay for detecting antibodies directed against Zika virus NS1 has been developed and used for diagnosing Zika infection. This NS1-based assay was significantly more specific than envelope protein-based assays, suggesting that similar assays might be more specific for other flaviviruses as well. This review summarizes the knowledge on flaviviruses’ NS1′s potential role in antigen and antibody diagnosis.