Miracle-dz/UniFAR-FTUs huggingface dataset:
The AGoRA V2 Unilateral Lower-Limb Exoskeleton: Mechatronic Integration and Biomechanical Assessment

People who suffer from stroke have a higher difficulty performing gait activity, affecting their quality of life. New technologies have been developed to assist and rehabilitate the affected limbs. This paper presents the AGoRA V2 unilateral lower-limb exoskeleton and the assessment of physiological and spatiotemporal parameters of gait in 10 subjects who participated in a test. AGORA V2 combine a stiff structure for the Hip and Knee and the T-FLEX ankle exoskeleton (soft structure). The results showed a significant decrease in muscle activity compared to the condition without an exoskeleton. This decrease was 8% in Biceps Femoris (BF) muscle activity and 4% in Vastus Medialis (VM) muscle activity, generated by proper assistance of the devices thigh muscles. Tibialis Anterior (TA) and Lateral Gastrocnemius (LG) muscles and gait times did not show significant changes, which can be interpreted as a correct synchronisation of the devices with the person’s gait. The results obtained can be used as a baseline for future studies with pathological patients.
Safety and concerns of hormonal application in farm animal production: a review

ABSTRACT Veterinarians and animal producers use non-essential compounds via either feed additives or implantation for a long history as growth promoters for farm animals. These compounds, such as anabolic hormones, bovine somatotropin, Beta-agonists, have multiple positive effects and improve animal performance in many meat-exporting countries due to their anabolic activity. However, some of them may cause carcinogenic effects to the consumer. Anabolic hormones are now permitted to be used as growth promoters on a global scale, but have not been permitted in the EU since 1988. Unlawfully, drugs are sometimes added to farm animal feeds to improve muscle growth, feed utilization efficiency, milk production, and nitrogen retention in order to obtain an economic benefit in a shorter period. In this article, we review the current knowledge on the safety and hazard of an anabolic compound as endocrine disruptor, not only on food, animals and public health but also on the environment, to arrive at recommendations for risk management and avoidance. The U.S. Food and Drug Administration approves seven hormone drugs (testosterone propionate, trenbolone acetate, estradiol, zeranol, progesterone, melengestrol acetate, and bovine somatotropin) for use in food animals for many purposes. Synthetic hormones were higher stability and longer persistence in the environment.
Land Use and Climate Change Altered the Ecological Quality in the Luanhe River Basin

Monitoring and assessing ecological quality (EQ) can help to understand the status and dynamics of the local ecosystem. Moreover, land use and climate change increase uncertainty in the ecosystem. The Luanhe River Basin (LHRB) is critical to the ecological security of the Beijing–Tianjin–Hebei region. To support ecosystem protection in the LHRB, we evaluated the EQ from 2001 to 2020 based on the Remote Sensing Ecological Index (RSEI) with the Google Earth Engine (GEE). Then, we introduced the coefficient of variation, Theil–Sen analysis, and Mann–Kendall test to quantify the variation and trend of the EQ. The results showed that the EQ in LHRB was relatively good, with 61.08% of the basin rated as ‘good’ or ‘excellent’. The spatial distribution of EQ was low in the north and high in the middle, with strong improvement in the north and serious degradation in the south. The average EQ ranged from 0.58 to 0.64, showing a significant increasing trend. Furthermore, we found that the expansion of construction land has caused degradation of the EQ, whereas climate change likely improved the EQ in the upper and middle reaches of the LHRB. The results could help in understanding the state and trend of the eco-environment in the LHRB and support decision-making in land-use management and climate change.
Efficacy of Licensed Monoclonal Antibodies and Antiviral Agents against the SARS-CoV-2 Omicron Sublineages BA.1 and BA.2

Newly emerging SARS-CoV-2 variants may escape monoclonal antibodies (mAbs) and antiviral drugs. By using live virus assays, we assessed the ex vivo inhibition of the B.1 wild-type (WT), delta and omicron BA.1 and BA.2 lineages by post-infusion sera from 40 individuals treated with bamlanivimab/etesevimab (BAM/ETE), casirivimab/imdevimab (CAS/IMD), and sotrovimab (SOT) as well as the activity of remdesivir, nirmatrelvir and molnupiravir. mAbs and drug activity were defined as the serum dilution (ID50) and drug concentration (IC50), respectively, showing 50% protection of virus-induced cytopathic effect. All pre-infusion sera were negative for SARS-CoV-2 neutralizing activity. BAM/ETE, CAS/IMD, and SOT showed activity against the WT (ID50 6295 (4355–8075) for BAM/ETE; 18,214 (16,248–21,365) for CAS/IMD; and 456 (265–592) for SOT) and the delta (14,780 (ID50 10,905–21,020) for BAM/ETE; 63,937 (47,211–79,971) for CAS/IMD; and 1103 (843–1334) for SOT). Notably, only SOT was active against BA.1 (ID50 200 (37–233)), whereas BA.2 was neutralized by CAS/IMD (ID50 174 (134–209) ID50) and SOT (ID50 20 (9–31) ID50), but not by BAM/ETE. No significant inter-variant IC50 differences were observed for molnupiravir (1.5 ± 0.1/1.5 ± 0.7/1.0 ± 0.5/0.8 ± 0.01 μM for WT/delta/BA.1/BA.2, respectively), nirmatrelvir (0.05 ± 0.02/0.06 ± 0.01/0.04 ± 0.02/0.04 ± 0.01 μM) or remdesivir (0.08 ± 0.04/0.11 ± 0.08/0.05 ± 0.04/0.08 ± 0.01 μM). Continued evolution of SARS-CoV-2 requires updating the mAbs arsenal, although antivirals have so far remained unaffected.
The University as an Adaptive Resilient Organization: A Complex Systems Perspective

Abstract This chapter provides an alternative conception of universities and the higher education systems in which they operate in an attempt to comprehend the ways in which such institutions and systems adapt and maintain themselves over time. Conceptually, it builds on complex systems theory, most notably critical insights from the study of complexity. We base our empirical analysis on developments across the European continent in the light of recent efforts to modernize university systems in the context of rising competition and pressures toward vertical and horizontal differentiation. We contrast two models of the university – strategic versus resilient – and critically reflect on the implications their differences have for the development of systems and universities and future research work in the area.
E¡ects of amiodarone on K 1 , internal pH and Ca 2 1 homeostasis in Saccharomycescerevisiae

In this study, amiodarone, at very low concentrations, produced a clear efﬂux of K 1 . Increasing concentrations also produced an inﬂux of protons, resulting in an increase of the external pH and a decrease of the internal pH. The K 1 efﬂux resulted in an increased plasma membrane potential difference, responsible for the entrance of Ca 2 1 and H 1 , the efﬂux of anions and the subsequent changes resulting from the increased cytoplasmic Ca 2 1 concentration, as well as the decreased internal pH. The D tok1 and D nha1 mutations resulted in a smaller effect of amiodarone, and D trk1 and D trk2 showed a higher increase of the plasma membrane potential. Higher concentrations of amiodarone also produced full inhibition of respiration, insensi-tive to uncouplers and a partial inhibition
The role of psychological capital in predicting academic achievement among undergraduate students of a Malaysian private university

Psychological resources may have an essential role in explaining students’ academic outcomes. The purpose of this study is to examine the influence of psychological capital on academic achievement among undergraduate students. In addition, the correlations of the individual component of psychological capital (hope, self-efficacy, resilience and optimism) and academic achievement were examined as well. The participants of this study are the undergraduate students from different faculties of a private university in Malaysia. The re-sponses from 390 undergraduate students were used for data analysis. Results from Pearson correlation analysis show that hope, self-efficacy, resilience, and optimism were positively correlated with academic achievement. In hierarchical regression analysis, two demographic variables (gender and age) were controlled. The results revealed that psychological capital has a positive influence on undergraduate students’ academic achievement. As such, appropriate training interventions that can improve psychological capital among students should be designed.
ROCKSTAR’S OPEN WORLD VIDEO GAMES AS IDEOLOGICAL APPARATUSES

Juho Tuominen: ROCKSTAR’S OPEN WORLD VIDEO GAMES AS IDEOLOGICAL APPARATUSES: A CASE STUDY OF RED DEAD REDEMPTION SERIES Master’s Thesis Tampere University Internet and Game Studies October 2020 The topic of this thesis stems from a desire to better understand the political and ideological dimensions of virtual worlds. This is a particularly interesting subject, because the game industry itself tends to undermine political and ideological dimensions of the games they produce. However, a video game is a highly constructed cultural artifact and thus a video game should be considered as a powerful rhetorical tool, which make use of multiple rhetorical resources simultaneously, including audiovisual design, storytelling, character development, mechanics, gameplay and so on (Bogost, 2007). This thesis understands a video game as a playable representation and acknowledges that video games by their very nature are at the intersection of both system and representation. The purpose of this study is to examine video games as ideological apparatuses. The goal of the thesis is to offer an insight on how to better understand the reality of virtual space as an ideological landscape. The goal is approached by utilizing Louis Althusser’s (2012) theory of ideological state apparatuses to open-world adventure video games. The usefulness of Althusser’s theory is demonstrated by closely analyzing the Rockstar Games’ representation of the West in Red Dead Redemption series. The key argument of the study is that video games function as ideological apparatuses on two levels. First, they are a part of cultural ideological state apparatuses. Second, video games themselves render in front of us completely new worlds with their own ideological apparatuses. As a result of the study, a reader understands the nature of a video game as an ideological apparatus and can recognize the ideological and political underpinnings of a virtual reality rendered for them in a video game.
Stable, Loop-Free, Multi-Path Inter-Domain Routing Using BGP

We introduce the concept of a routing etiquette as the set consisting of the information maintained by routers, local operations that can be carried out on such information, and the information that routers share with one another to reach stable routes using local private policies for path selection. OPERA is presented as one such etiquette. Sufficient conditions for stable and loop-free routing based on OPERA are proven. Based on these results, BGP is proven to be inherently unstable and prone to looping, and the policy mechanisms of BGP are modified slightly to attain OPERA-based BGP (OBGP). OBGP is the first loop-free inter-domain multi-path routing solution based on BGP. OBGP is proven to be stable and loop-free. Well-known examples of systems in which BGP does not converge are used to show the benefits of OBGP.
Assessment of clinical profiles, and treatment outcomes for children with diabetic ketoacidosis, in two hospitals selected from Addis Ababa, Ethiopia, 2020.

Background: Type 1 diabetes mellitus (T1DM) is a common autoimmune disorder that often presents in children. In these patients, diabetic ketoacidosis (DKA) is one of the most common and serious acute complications, which is associated with significant morbidity and mortality. The study aimed to assess the clinical profiles and outcomes of children admitted with DKA. Objective: To assess the clinical manifestations and treatment outcomes of DKA patients in two tertiary hospitals in Addis Ababa. Methods : A hospital-based retrospective analysis was conducted on 175 pediatric diabetic ketoacidosis children, who were admitted to the emergency units of two hospitals in Addis Ababa from September 2015 to February 2020 and whose medical records contained complete pertinent data. Patients were between the ages of 0 to 12 years. Proportional samples were taken from each hospital and data was collected retrospectively using a formatted checklist. The data was checked for its inclusiveness and entered Epi Info. version 4.6 and then transferred into SPSS version 25 software for further analysis. Result: DKA was the presenting manifestation of Diabetes in 78.3% of patients and 21.7% were already known cases of Diabetes. Half (50.9%) of the study participants were diagnosed with DKA in the age range of 5 to 10 years and almost one-third (30.9%) were above the age of 10. A high-income level of the caretakers was found to be protective against DKA during the diagnosis of T1DM. Out of the 175 children admitted, 12 passed on, resulting in a mortality rate of 6.9%. Conclusion: The majority of the known DM patients presented with DKA after the omission of insulin and a newly diagnosed T1DM at first presentation. The age of presentation and clinical symptoms of the studied participants were like other international studies. Community education regarding the signs and symptoms of childhood DM can further prevent the development of DKA. [ Ethiop. J. Health Dev . 2022; 36(2):000-000]
Theoretical Study on the Kinetics of a Special 1 Particle Swarm 2

Prior studies have focused on the overall behavior of randomly moving particle swarms. However, the character- 6 istics of ubiquitous special particle swarms that form in these swarms remain unknown. This study demonstrates a 7 generalized diffusion equation for randomly moving particles that considers the velocity and location aggregation 8 effects in a special circumstance (that is, in a moving reference frame R u relative to a stationary reference frame 9 R 0 ). This equation can be approximated as the Schrödinger equation in the microcosmic case and describes the 10 kinetics of the total mass distribution in the macrocosmic case. The predicted density distribution of the particle 11 swarm in the stable aggregation state is consistent with the total mass distribution of massive, relaxed galaxy clus- 12 ters (at least in the range of r < r s ), preventing cuspy problems in the empirical Navarro-Frenk-White (NFW) 13 proﬁle. This article is helpful for inspiring people to think about the essence of universal gravitation.
What Can History Tell Us? Identifying Relevant Sessions for Next-Item Recommendation

Recommendation systems have been widely applied to many Ecommerce and online social media platforms. Recently, sequential item recommendation, especially session-based recommendation, has aroused wide research interests. However, existing sequential recommendation approaches either ignore the historical sessions or consider all historical sessions without any distinction that whether the historical sessions are relevant or not to the current session, which motivates us to distinguish the effect of each historical session and identify relevant historical sessions for recommendation. In light of this, we propose a novel deep learning based sequential recommender framework for session-based recommendation, which takes Nonlocal Neural Network and Recurrent Neural Network as themain building blocks. Specifically, we design a two-layer nonlocal architecture to identify historical sessions that are relevant to the current session and learn the long-term user preferences mostly from these relevant sessions. Besides, we also design a gated recurrent unit (GRU) enhanced by the nonlocal structure to learn the short-term user preferences from the current session. Finally, we propose a novel approach to integrate both long-term and shortterm user preferences in a unified way to facilitate training the whole recommender model in an end-to-end manner. We conduct extensive experiments on two widely used real-world datasets, and the experimental results show that our model achieves significant improvements over the state-of-the-art methods.
DMSO_A_280350 4157..4167

1School of Kinesiology, Shanghai University of Sport, Shanghai, People’s Republic of China; 2State Key Laboratory of Genetic Engineering, Department of Endocrinology and Metabolism, Institute of Metabolism and Integrative Biology, Human Phenome Institute, School of Life Sciences, Zhongshan Hospital, Fudan University, Shanghai, People’s Republic of China; 3Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; 4Global Asia Institute, National University of Singapore, Singapore; 5N.1 Institute for Health, National University of Singapore, Singapore Purpose: To (i) describe the characteristics of physical fitness and cardiometabolic risk in Chinese university students with normal-weight obesity (NWO); (ii) assess the association between NWO with physical fitness and cardiometabolic risk. Methods: A total of 249 participants from the 2018 Shanghai University of Sport Alumni Health Cohort Study in China formed the study cohort. NWO was defined as normal body mass index (17.9–23.9 kg/m for males; 17.2–23.9 kg/m for females) but with excess bodyfat percentage (≥20% for males; ≥30% for females). Body composition was assessed by dual-energy X-ray absorptiometry. Physical-fitness scores were calculated from a battery of sex-specific tests. Cardiometabolic risk was calculated using a continuous clustered risk (MetS) score. Results: We found that 16.7% of male and 45.3% of female university students were classified as having NWO. Participants with NWO showed worse cardiorespiratory fitness than those with normal weight (NW) (male NWO (37±8) vs male NW (41±6) mL/kg/min, p<0.01; female NWO (31±4) vs female NW (33±6) mL/kg/min, p<0.01). NWO was associated negatively with the fitness score (OR = 0.853; 95% CI = 0.793–0.917) and was associated positively with the MetS score (1.280; 1.162–1.410). Conclusion: University students with NWO were characterized by higher cardiometabolic risk and lower levels of physical fitness. Our findings implied that university students with NWO should be mindful of the potential hidden health risks of excess body fat and participate in exercise to enhance physical fitness.
Effect of Altered p02 in the Aerial Part of Soybean on Symbiotic N2 Fixation1

S Dry matter accumulation, nitrogen content and N2 fixa- tion rates of soybean (Glycine max [L.] Merr. cv. Wye) plants grown in chambers in which the aerial portion was exposed to a pO2 of 5, 10, 21, or 30% and a pCO2 of 300 Il C02/1 or a p0 of 21% and a pCO2 of 1200 p,l C02/1 during the complete growth cycle were measured. Total N2[C2H2] fixed was increased by CO2/02 ratios greater than those in air and was decreased by ratios smaller than those in air; the effects on N2 fixation of decreased pO2 or elevated pCO2 were quanti-tatively similar during the period of vegetative growth. Decreased pO2 produced a smaller increase then elevated pCO, during the reproductive period, presumably because of the decreased sink activity of the arrested reproductive growth under subambient pO2 . At a pO of 5% and a pCO of 300 ,l C02/l total N2 fixed was increased 125% and per cent nitrogen content in the vegetative parts was increased relative to air while that in the seed was decreased. Dry matter production was increased and reproductive growth was arrested as previously reported for plants receiving only fertilizer nitrogen. At a pO2 of 30% and a pC02 of 300 JI C02/1 total N2 fixed was decreased 50% and per cent nitro- gen content in the vegetative part was increased relative to air while that in the reproductive structures was unaf- fected. Dry matter production was similarly decreased in both vegetative and reproductive structures. These effects of altered pO2 in the aerial part on N2 fixation are consistent with
A New and Evolving Era in Multiple Myeloma Field

Multiple myeloma (MM) is one of the most common hematologic disorders in US, which accounts for approximately 15% of hematologic malignancies [1]. The American Cancer Society estimates that about 30,330 people will be diagnosed with multiple myeloma and about 12,650 will die of the disease in 2016 [1]. The number of people diagnosed with MM has been increasing over the past ten years, fortunately, with the deeper understanding of the disease and advances in treatment and research, more novel therapeutic classes have been granted FDA approval and incorporated into treatment leading to treatment paradigm change and significantly improved patients’ survival [2]. To address recent discoveries about the molecular pathogenesis of the disease, International myeloma working group (IMWG) has updated diagnostic criteria and staging system for Multiple myeloma [3,4]. Recently National Comprehensive Cancer Network (NCCN) has updated its guideline to reflect rapid progress in the management of multiple myeloma [5]. The purpose of this review is to highlight some of most recent changes and significant progress in multiple myeloma clinical practice from basic disease definition changes to the advancement of therapeutic options including most recently FDA approved anti-myeloma agents as well as some promising novel therapeutic approaches under clinical development. In Situ Hybridization; R-ISS: Revised International Staging System; PD-1: Programmed T cell death 1; PD-L1: Programmed Death-Ligand1; HDT/ASCT: High-Dose Therapy/Autologous Stem Cell Transplantation; NCCN: National Comprehensive Cancer Network; IMWG: International Myeloma Working Group; MFC: Multiparameter-Flow-Cytometry; CRd: Carfilzomib Combined with Lenalidomid and Dexamethasone; ERd : Elotuzumab in combination with Lenalidomide and Dexamethasone; RRMM: Relapsed or Refractory Multiple Myeloma; NDMM: Newly Diagnosed Multiple Myeloma; CAR: Chimeric Antigen Receptor T cells; PET/CT: Positron Emission Tomography Computed Tomography; LDH: Lactate Dehydrogenase; SMM: Smoldering Multiple Myeloma
Utilising Gliricidia sepium leaf meal as a protein substitute in cassava-based supplements to increase average daily gain of Ongole bulls and income of smallholder farmers

Context . Formulating supplements with Gliricidia sepium leaf meal (GLM) and cassava powder to promote liveweight gain of Ongole bulls. Aims . This study was conducted to evaluate the effect of using GLM as a substitute for copra meal (CM) or soybean hulls (SBH) in a concentrate containing dry cassava powder (DCP) on the average daily gain of Ongole bulls and income over feed cost. Methods . Forty Ongole bulls were allocated in a randomised block design with 10 head per treatment. The control group (R 0 ) was provided the current feeding system (CFS) fed ad libitum , with supplemented treatments consisting of the current feeding system fed ad libitum + 1% liveweight (on approximate DM basis)/day of three different concentrate supplement diets (R 1 , R 2 and R 3 ). R 1 concentrate contained 50% DCP, 25% CM and 25% SBH; R 2 was 50% DCP, 25% GLM and 25% SBH; and R 3 was 50% DCP, 25% CM and 25% GLM. The bulls belonged to cooperative smallholder farmers in the Banaran and Bleberan villages, Playen Subdistrict, Gunungkidul Regency, Yogyakarta, Indonesia. The experiment was performed for 12 weeks from 22 December 2018 to 16 March 2019. Key results . The average weight gain of bulls (kg/head) in the treatments R 0 , R 1 , R 2 and R 3 were 0.31, 0.75, 0.61 and 0.62, respectively. The income over feed cost of supplement treatments R 1 , R 2 and R 3 was double that of the control (R 0 ). Conclusions . It was concluded that GLM can replace the use of SBH and CM in a cassava-based supplement and increase the income of farmers in this district. Implications . Cassava powder can be combined with GLM to form a concentrate that increases the average weight gain of Ongole bulls and income of farmers.