Miracle-dz/UniFAR-FTUs huggingface dataset:
Effectiveness of pelvic floor muscles training on females’ sexual function throughout pregnancy and postpartum

Objective: This study aimed to evaluate effectiveness of pelvic floor muscles training on females’ sexual function throughout pregnancy and postpartum. Methods: A quasi experimental research design was applied at the antenatal clinic of Mansoura University hospital, Egypt. A purposive sample of 72 nulliparous singleton pregnant client free from any connotation affect sexual practice was studied. The subjects were allocated into two groups; control group received conventional antenatal and postnatal care, while the intervention group received the same care besides performing pelvic floor muscle exercise at 20 weeks pregnancy until 10-12 weeks postpartum. Female sexual function, sexual quality of life, and strength of the pelvic floor muscle contraction were evaluated at baseline, at 28-30 weeks gestation, and at 10-12 weeks postpartum, by using the female sexual function index scale, sexual quality of life-female, and the Oxford grading scale. Results: The total female sexual quality of life index scores in the intervention group were higher than those of the control group at the pregnancy and postpartum follow ups (22.3 ± 6.9 vs. 15.9 ± 6.8 & 26.0 ± 6.7 vs. 13.5 ± 6.3 respectively; p < .001). The sexual quality of life-female scores were significantly higher in the intervention group than in the control group at the pregnancy follow up evaluation (54.2 ± 15.9 vs. 36.9 ± 9.7 respectively, p < .001) and at the postpartum follow up evaluation (59.8 ± 13.5 vs. 30.3 ± 7.0 respectively, p < .001). The pelvic floor muscles strength was significantly better in the intervention group than in the control group at the pregnancy follow up evaluation and at the postpartum follow up evaluation. Conclusions: Pelvic floor muscle training during early gestation weeks was an effective tool for improvement of the female sexual function, sexual quality of life-female, and pelvic floor muscles strength during pregnancy and postpartum. Thus, it should be encouraged for pregnant mothers at early weeks and continued till postpartum.
Tahap Penguasaan Kosa Kata Bahasa Arab Pelajar Universiti: Satu Kajian Korpus di Universiti Sains Islam Malaysia

Kelemahan dalam bahasa Arab dalam kalangan pelajar peringkat universiti di Malaysia khususnya dapat dikaitkan dengan kelemahan mereka dalam menguasai jumlah kosa kata yang mencukupi. Kesan daripada situasi ini menyebabkan ketidakmampuan mereka untuk menggunakan bahasa Arab dengan baik dalam apa jua situasi dalam kemahiran bahasa. Justeru, tujuan kajian ini dijalankan adalah untuk mengenalpasti maksud penguasaan kosa kata dan saiz kosa kata ideal untuk pembelajaran bahasa Arab pada peringkat univeristi. Ia juga bertujuan untuk menilai sejauh mana mereka mampu menguasai jumlah kosa kata tersebut. Bagi mencapai objektif pertama, kaedah analisis dokumen telah dijalankan. Manakala bagi objektif kedua, ujian penguasaan kosa kata pula dijalankan ke atas 59 orang pelajar tahun satu di Fakulti Pengajian Bahasa Utama di USIM dengan berpandukan kepada Corpus of Contemporary Arabic (CCA). Ujian ini melihat kepada kemampuan pelajar menyatakan jenis perkataan, pola, makna dan kebolehan mereka membina ayat yang lengkap menggunakan perkataan yang disenaraikan dalam CCA tersebut. Keputusan ujian penguasaan kosa kata ini mampu memberikan gambaran saiz kosa kata yang dikuasai pelajar dan seterusnya menghubungkan situasi tersebut dengan kelemahan pelajar peringkat universiti dalam menuturkanbahasa Arab secara keseluruhannya. Dapatan kajian menunjukkan bahawa pelajar secara umumnya hanya mampu menguasai jumlah kosa kata sekitar 1500-2000 perkataan sahaja. Manakala, hasil analisis dokumen menyimpulkan bahawa pelajar peringkat universiti yang mempelajari bahasa asing sebagai bahasa kedua seperti bahasa Arab sepatutnya menguasai sekitar 3000-5000 perkataan bagi memudahkan mereka mengikuti pengajian dalam bidang mereka. Low proficiency in Arabic language among university students specifically in Malaysia can be attributed to their inability to master sufficient number of vocabulary. This consequently affects their ability to effectively use Arabic in any situations. This study therefore aims to investigate vocabulary mastery and the appropriate vocabulary size for learning Arabic at tertiary level. This study also aims to assess the extent students are able to master the appropriate vocabulary size. Document analysis was conducted to achieve the first objective, and for the second objective, based on the Corpus of Contemporary Arabic (CCA), a vocabulary mastery test was administered to 59 first year students at the Faculty of Major Language Studies, USIM. The test measured the students’ ability to determine word categories, patterns and meanings, and to build complete sentences using the listed vocabulary in the CCA. The vocabulary mastery test was able to provide students’ vocabulary size, and link this level of competency to their proficiency in communicating using Arabic. The findings revealed that the students were generally able to master about 1500-2000 Arabic words. Meanwhile, the document analysis concluded that university students learning a second language like Arabic need to master around 3000-5000 words in order to ease their learning.
Evaluation of the Storage Effect Considering Possible Redevelopment Options of the Peace Dam in South Korea

The Peace Dam is one of two flood control dams in South Korea. Located near the demilitarized zone (DMZ) between North and South Korea, the Peace Dam was constructed as a counter measure to the Imnam Dam of North Korea. However, the recent reconciliation efforts between North and South Korea have raised the possibility for the redevelopment of the Peace Dam to be a multi-purpose dam. This study evaluates the possible increase of the flood control ability of the Peace Dam under the condition of its redevelopment. The allocation of flood control and water conservation storage as well as the reservoir operation method is determined to follow the other similar-sized dams in Korea. The flood control ability is quantified by introducing the concept of a storage coefficient. In order to estimate the storage coefficient, an exponential nonlinear reservoir model was used. The results can be summarized as follows: First, the current Peace Dam, a flood control dam, is found to have a small flood control ability. Quantified by the storage coefficient, the flood control ability of the current Peace Dam is estimated to be just 3.9 h. Second, the maximum storage coefficient of the Peace Dam can be increased up to 22.6 h. Here, it is assumed that the dam is operated by the rigid reservoir operation method (rigid ROM) in which the discharge is determined by applying a constant rate (specifically, 0.5 in this study) to the inflow until the peak inflow is reached. In addition, this result is based on the assumption that the ratio between water conservation storage and flood control storage is three. That is, even though the flood control storage is set at just 25% of the total storage, the storage coefficient is increased to be more than five times that of the current Peace Dam. In addition, secured water conservation storage can significantly increase the benefits associated with the redevelopment of the Peace Dam.
Atypical Functional Connectivity in Tourette Syndrome Differs Between Children and Adults

Background Tourette syndrome (TS) is a neuropsychiatric disorder characterized by motor and vocal tics that typically change over development. Whether and how brain function in TS also differs across development has been largely understudied. Here, we used functional connectivity MRI to examine whole brain functional networks in children and adults with TS. Methods Multivariate classification methods were used to find patterns among functional connections that distinguish TS from controls separately for children and adults (total N = 202). We tested whether the patterns of connections that classify diagnosis in one age group (e.g., children) could classify diagnosis in another age group (e.g., adults). We also tested whether the developmental trajectory of these connections were altered in TS. Results Patterns of functional connections that distinguished TS from controls were generalizable to an age-matched independent test set, but not to other age groups. While diagnostic classification was successful in children and adults separately, the connections that best distinguished TS from controls were age-specific. When contextualized with typical development, some functional connections exhibited accelerated maturation in childhood TS, while others exhibited delayed maturation in adulthood TS. Conclusions Our results demonstrate that brain networks are differentially altered in children and adults with TS, and that the developmental trajectory of affected connections is disrupted. These findings further our understanding of neurodevelopmental trajectories in TS and carry implications for future applications aimed at predicting the clinical course of TS in individuals over development.
Continuing CHAAOS: Vocabulary Intervention for Students With Disabilities in Eighth Grade Who Are Also English Learners

Few studies have considered academic vocabulary interventions for students who have learning disabilities (LD) and also are English learners (EL). This research explored the effects of the third year of the Creating Habits that Accelerate Academic Language of Students (CHAAOS) vocabulary intervention for eighth-grade students who received English Language Arts instruction (ELA) in special education classes. Over 70% of student participants had LD and over half were EL. Special education teachers delivered 12 weeks of intervention spaced across 7 months to 36 students. Researchers compared outcomes on receptive and expressive measures with 17 students in business-as-usual (BAU) special education ELA. Students receiving the CHAAOS intervention learned the 48 taught words better than students in BAU conditions, retained their knowledge of words 4 weeks following the close of the intervention, and ended the year with higher vocabulary scores on a standardized measure than students in BAU classes. Students who were EL performed similarly on receptive knowledge of words to students who were native English speakers. This study documents the effectiveness of explicit vocabulary routines for students who have LD and are also EL.
Estrous Cycle and Early Pregnancy of White Mice Exposed to Methomyl

Methomyl is an oxime carbamate pesticide that is widely used in the Philippines. This insecticide is known to be an endocrine disrupting chemical and a potent genotoxic in mammalian cells. However, limited studies were conducted specifically on its direct effects on estrous cycle and its teratogenic effect. This study aimed to (a) assess the effect of methomyl on the body weight and on the estrous cycle of mice, and; (b) examine the teratogenic effect of methomyl on the progeny of the female albino mice. Five week-old experimental mice in three treatment setups were used in the study for both independent experiments. The treatment schedule for pregnant mice was administered during organogenesis (day 6 to 15 of gestation). Results showed that the average gained weight of the mice of both high dose (HD) and low dose (LD) groups were lower as compared to the average gained weight of the control group but did not show any statistical significant differences (p=0.562). For the experiment 1, methomyl significantly (p=0.013) affect the estrous cycle of the mouse especially in LD group. For experiment 2, results revealed that there was a significant difference among the treatment set-ups (p=0.0001) in terms of fetal morphometric measurement. Furthermore, abnormality and high number of resorption was also observed in both LD and HD treatment groups. Therefore, methomyl significantly affect the body weight, estrous cycle and fetal morphometry. This further confirm that methomyl is an endocrine disrupting and genotoxic chemical that affects the estrous cycle and causes teratogenic effect.
Ichthyofauna composition of Alape River, Igbokoda, South West Nigeria

Objectives: To study ichthyofauna composition of Alape River, Igbokoda, Ilaje Local Government Area ofOndo State, Nigeria.Method: Samplingwas done for a period of three months, from the month of November 2019 to January 2020. Data for this study were based on the record of fish caught by local fishermen. Findings: A total of twenty thousand, four hundred and nine (20,409) individual fishes of six species (Heterotis niloticus, Clarias gariepinus, Chrysichthys nigrodigitatus, Gymnarchus niloticus, Oreochromis aureaus and Hepsetus odoe), belonging to six families (Arapaimidae, Clariidae, Claroteidae, Gymnarchidae, Cichlidae and Hepsetidae) were recorded for the whole period of study. The over-all comparison among themonths of study shows that January recorded the highest catch (6,919) with an over-all relative percentage abundance of 33.9%, followed by December (6,871) with 33.67%. The least catch (6,619) was observed in the month of November with a relative percentage abundance of 32.43%. The study showed that Clarias gariepinus and Oreochromis aureus were dominant fish species, Chrysichthys nigrodigitatus was sub-dominant, Heterotis niloticus and Hepsetus odoe were occasional while Gymnarchus niloticus was rare in River Alape. The results of this study showed that the river has low fish species composition and abundance in spite of the size of the river. Considering this fact, there is need for further survey to cover more months. There is also a need to evolve strategies for effective utilization and proper management of the river for optimum fish production, sustainability and conservation.
Prunus nutantiflora (Rosaceae), a New Species from Hunan Province, China

Prunus nutantiflora D.G. Zhang & Z.H. Xiang sp. nova (Rosaceae) from Hunan Province, China, is described, illustrated and compared with morphologically similar species. Prunus nutantiflora resembles especially P. xueluoensis in having three axillary winter buds and an ellipsoid drupe, but differs from it by having a densely pilose style base and a campanulate hypanthium (ca. 4 × 2.5 mm).
Vascular Targeting for Radioimmunotherapy with 213Bi

Effective targeting of short-lived α-emitters such as Bi can be accomplished only with agents that localize rapidly. One such approach uses MAbs that bind to the luminal side of tumor vasculature. MAbs 34A and 201B bind to murine thrombomodulin which is found in lung endothelium. These MAbs were derivatized with CHXb—DTPA and bound Bi. The labeled MAbs were shown to deliver over 50% of the injected dose to mouse lungs. The Bi remained in the lungs with a f1/2 > 4 h, and there was only slight deposition of isotope at other sites (kidney, liver, spleen). Bi coupled to MAb was shown to kill tumor cells in tissue culture efficiently. Injection of large doses (600 μΟ) of Bi MAb 201 into mice that had previously been injected with EMT-6 tumor cells to form lung colonies resulted in hemorrhage in tumor and normal lung tissue at 4 days post injection. Lower doses (<300 μΟίΜπίπ^) were better tolerated in normal tissue. Successful targeting of Bi to tumor vasculature has been accomplished in this model system and has significant promise for therapy in humans when appropriate targeting reagents are identified.
The Resilience of French Companies to the COVID-19 Crisis

This paper explores the resilience of French listed companies to the COVID-19 shock. We examine the effect of numerous firm characteristics related to financial flexibility, ownership structure, corporate governance, and corporate social responsibility on the stock returns during the COVID-19 shock. Our results show that French companies with more debt and less profitability experience worse stock returns, indicating the role played by financial flexibility. We also find that firms with greater ownership by short-term investors or active investors experience worse stock returns during the COVID-19 shock, suggesting that a base of shareholders with long-term orientation and commitment helps firms to weather the effect of market-wide shocks.
Actin dynamics drive microvillar motility and clustering during brush border assembly

During differentiation, transporting epithelial cells generate large arrays of microvilli known as a brush borders to enhance functional capacity. To develop our understanding of brush border formation, we used live cell imaging to visualize apical surface remodeling during early stages of this process. Strikingly, we found that individual microvilli exhibit persistent active motility, translocating across the cell surface at ~0.2 μm/min. Perturbation studies with inhibitors and photokinetic experiments revealed that microvillar motility is driven by actin assembly at the barbed-ends of core bundles, which in turn is linked to robust treadmilling of these structures. Because the apical surface of differentiating epithelial cells is crowded with nascent microvilli, persistent motility promotes collisions between protrusions and ultimately leads to their clustering and consolidation into higher order arrays. Thus, microvillar motility represents a previously unrecognized driving force for apical surface remodeling and maturation during epithelial differentiation.
Neuroendocrine Carcinoma of the Head and Neck: HPVStatus and Co-Expression of Immunomodulating Receptors

Introduction: Lately, HPV-association of head and neck tumors has frequently been described in the literature, occurring not only in squamous cell carcinomas, but also in the less common neuroendocrine carcinomas (NEC) of the head and neck region. The PD-1/PD-L1 checkpoint was found to be associated with a better outcome in patients with HPV-positive squamous cell carcinoma. It is source to antibody-therapies, such as Pembrolizumab. Methods: The aim of this study was to determine the HPV-status of NEC of the head and neck region that were collected at our department during surgery in the course of the last 11 years. Additionally, the samples were analyzed in terms of their expression of PD-1, PD-L1 and PD-L2. Results: Seven different NEC tumor samples of the head and neck region were analyzed; three of them (43%) showed HPV-association. All three HPV-positive samples showed HPV type 18 on molecular pathological analysis. Expression of PD-1 and PD-L1 differed widely between the samples and showed no correlation to the HPV-status. PD-L2 showed a stronger expression in HPV-positive samples. Conclusion: HPV type 18 appears to be frequently associated with NEC. PD-L1 und PD-L2 expression varies widely in NEC. Its role in NEC to date remains unclear. Multicentric studies are required.
Identification and characterization of yeast and human glycosphingolipid flippases

Lipid transport is an essential process with manifest importance to human health and disease. Phospholipid flippases (P4-ATPases) transport lipids across the membrane bilayer, and are involved in signal transduction, cell division, and vesicular transport. Mutations in flippase genes cause or contribute to a host of diseases such as cholestasis, neurological deficits, immunological dysfunction, and metabolic disease. Genome-wide association studies have shown that ATP10A and ATP10D variants are associated with an increased risk of diabetes, obesity, myocardial infarction, and atherosclerosis; and ATP10D SNPs are associated with elevated levels of glucosylceramide (GlcCer) in plasma from diverse European populations. Although sphingolipids are strong contributors to metabolic disease, little is known about how GlcCer is transported across cell membranes. We have identified an evolutionarily conserved clade of P4-ATPases from Saccharomyces cerevisiae (Dnf1, Dnf2), Schizosaccharomyces pombe (Dnf2), and Homo sapiens (ATP10A, ATP10D) that transport GlcCer. Further, we establish the structural determinants necessary for the specific recognition of this sphingolipid substrate. Our molecular observations clarify the relationship between these flippases and human disease, and have fundamental implications for membrane organization and sphingolipid homeostasis.
Novel platelet-neutrophil interaction via activated αIIbβ3 mediates NETosis under flow

Platelet-leukocyte interactions are important for innate immune responses, but also contribute to the pathogenesis of thrombotic disorders, such as deep vein thrombosis. How these interactions are manifest and how they influence leukocyte function remains poorly understood. Here, we demonstrate that binding to von Willebrand factor under flow through glycoprotein Ibα 9primes9 platelets resulting in intracellular Ca2+ release and αIIbβ3 activation. This priming enables platelets to bind leukocytes via a mechanism that is largely independent of P-selectin, but that is inhibited by blocking αIIbβ3. We show that neutrophils and T-cells bind directly to activated αIIbβ3 under flow, identifying this platelet integrin as a novel leukocyte receptor. Binding of neutrophils to αIIbβ3 under flow causes rapid intracellular Ca2+ release, and initiates Ca2+- and NADPH oxidase-dependent signaling leading to production of neutrophil extracellular traps (NETs). NET production is itself dependent upon a mechanosensitive mechanism, as NETosis is markedly diminished if neutrophils are captured by αIIbβ3 under static conditions. Taken together, these data demonstrate a novel mechanism for platelet-neutrophil cross-talk and mechanosensitive NET production.
Analysis of Anemia Using Data Mining Techniques with Risk Factors Specification

Deficiency in healthy Red Blood Cells (RBC) leads to insufficient oxygen to be carried to whole blood tissues. Many reasons cause such an issue like iron or vitamin deficiency which is known as Anemia. Pregnant women, children under the age of 6, people with a low vitamin diet and losing their blood due to surgery or injury are at risk that will tend to have anemia. Such a disease can be diagnosed by blood test called Complete Blood Count (CBC), which evaluates Hemoglobin levels of patient’s blood. Undiagnosed or untreated left disease, such as anemia, can cause health problems such as severe fatigue and pregnancy complications. Different types of anemia, especially those associated with iron or vitamin deficiency, can be ameliorated, especially when detected at an early stage. In this paper, four techniques, Bayesian Network (BN), Naive Bayes (NB), Logistic Regression (LR) and Multilayer Perceptron (MLP) have been applied to predict anemia based on 539 data, with 10 attributes, collected from laboratories. The LR has given better results compared to other considered techniques. In addition, attribute evaluators such as information gain have been applied to demonstrate the high performance of the system with minimum characteristics.
The Relationship between Individual Characteristics Factors and Occupational Factors with Testosterone Hormone Levels in Metal Casting Industry Workers

The working environment in the metal casting industry has a risk of being exposed to free radicals which affects a decrease in testosterone levels. This study aims to measure workers' testosterone levels and determine the relationship of individual characteristics and occupational factors with testosterone levels in the metal casting industry. This type of research is explanatory research with analytic survey design with cross sectional approach. The variables of this study include the dependent variable namely testosterone levels while the independent variables are age, years of work, type of work, nutritional status, marital status, and smoking habits. The research sample of 34 workers was taken by total sampling technique. Data analysis used univariate, bivariate and multivariate. The results showed that respondents who had abnormal testosterone levels were 4 or 11.8% while normal testosterone were 30 or 88.2%. Body Mass Index is related to testosterone levels but age, years of service, type of work, marital status, and smoking habits are not related to testosterone levels in metal casting industry workers CV. Bonjor Jaya Klaten.