Miracle-dz/UniFAR-FTUs huggingface dataset:
Predicted Stellar Kinematics of a Kiloparsec-Scale Nuclear Disc (or Ring) in the Milky Way

In Debattista et al. (2015), we proposed that a kiloparsec-scale nuclear disc is responsi- ble for the high-velocity secondary peak in the stellar line-of-sight velocity distributions (LOSVDs) seen at positive longitudes in the bulge by the Apache Point Observatory Galactic Evolution Experiment (APOGEE). Here, we make further qualitative but distinctive predictions of the kinematic properties of a nuclear disc, including for the LOSVDs at negative longitudes (which APOGEE-2 will observe) and examine the proper motions throughout the disc. Since a nuclear ring is also able to produce similar high-velocity LOSVD peaks, we present predictions for the proper motion signatures which distinguish between a nuclear disc and a nuclear ring. We also demonstrate that the stars in a nuclear disc, which would be on x2 orbits perpendicular to the bar, can remain on these orbits for a long time and can therefore be old. We show that such (old) nuclear discs of comparable size exist in external galaxies.
Virtual reality augments effectiveness of treadmill walking training in patients with walking and balance impairments: A systematic review and meta-analysis of randomized controlled trials

Objective To systematically summarize and examine current evidence regarding the combination of virtual reality and treadmill training in patients with walking and balance impairments. Data sources English language randomized controlled trials, participants with walking and balance impairments, intervention group used virtual reality and treadmill, control group only used treadmill with the same training frequency and number of sessions. Six bioscience and engineering databases were searched. Methods Two independent reviewers conducted study selection, data extraction, and quality assessment. Methodological quality was assessed using the Physiotherapy Evidence Database (PEDro) scale. Results Sixteen randomized controlled trials including 829 participants were identified. Compared to treadmill-only training, virtual reality augmented treadmill training induced significantly faster walking (p < 0.001; standardized mean difference (SMD) = 0.55, 95%CI: 0.30 to 0.81), longer step length (p < 0.001; SMD = 0.74, 95%CI: 0.42 to 1.06), narrower step width (p = 0.03; SMD = −0.52, 95%CI: −0.97 to −0.06), longer single leg stance period (p = 0.003; SMD = 0.77, 95%CI: 0.27 to 1.27), better functional mobility (p = 0.003; SMD = −0.44, 95%CI: − 0.74 to −0.15), improved balance function (p = 0.04; SMD = 0.24, 95%CI: 0.01 to 0.47), and enhanced balance confidence (p = 0.03; SMD = 0.73, 95%CI: 0.08 to 1.37). Walking endurance did not differ significantly between groups (p = 0.21; SMD = 0.13, 95%CI: −0.07 to 0.34). Conclusions Virtual reality augmented treadmill walking training enhances outcomes compared to treadmill-only training in patients with walking and balance impairments. The results of this review support the clinical significance of combining virtual reality with treadmill training with level 1A empirical evidence.
EVOLUTION OF ROTATIONAL VELOCITIES OF A-TYPE STARS

The equatorial velocity of A-type stars undergoes an acceleration in the first third of the main sequence (MS) stage, but the velocity decreases as if the stars were not undergoing any redistribution of angular momentum in the external layers in the last stage of the MS phase. Our calculations show that the acceleration and the decrease of the equatorial velocity can be reproduced by the evolution of the differential rotation zero-age MS model with the angular momentum transport caused by hydrodynamic instabilities during the MS stage. The acceleration results from the fact that the angular momentum stored in the interiors of the stars is transported outward. In the last stage, the core and the radiative envelope are uncoupling, and the rotation of the envelope is a quasi-solid rotation; the uncoupling and the expansion of the envelope indicate that the decrease of the equatorial velocity approximately follows the slope for the change in the equatorial velocity of the model without any redistribution of angular momentum. When the fractional age 0.3 ≲ t/tMS ≲ 0.5, the equatorial velocity remains almost constant for stars whose central density increases with age in the early stage of the MS phase, while the velocity decreases with age for stars whose central density decreases with age in the early stage of the MS phase.
Prolonged higher dose methylprednisolone versus conventional dexamethasone in COVID-19 pneumonia: a randomised controlled trial (MEDEAS)

Background Dysregulated systemic inflammation is the primary driver of mortality in severe coronavirus disease 2019 (COVID-19) pneumonia. Current guidelines favour a 7–10-day course of any glucocorticoid equivalent to dexamethasone 6 mg daily. A comparative randomised controlled trial (RCT) with a higher dose and a longer duration of intervention was lacking. Methods We conducted a multicentre, open-label RCT to investigate methylprednisolone 80 mg as a continuous daily infusion for 8 days followed by slow tapering versus dexamethasone 6 mg once daily for up to 10 days in adult patients with COVID-19 pneumonia requiring oxygen or noninvasive respiratory support. The primary outcome was reduction in 28-day mortality. Secondary outcomes were mechanical ventilation-free days at 28 days, need for intensive care unit (ICU) referral, length of hospitalisation, need for tracheostomy, and changes in C-reactive protein (CRP) levels, arterial oxygen tension/inspiratory oxygen fraction (PaO2/FIO2) ratio and World Health Organization Clinical Progression Scale at days 3, 7 and 14. Results 677 randomised patients were included. Findings are reported as methylprednisolone (n=337) versus dexamethasone (n=340). By day 28, there were no significant differences in mortality (35 (10.4%) versus 41 (12.1%); p=0.49) nor in median mechanical ventilation-free days (median (interquartile range (IQR)) 23 (14) versus 24 (16) days; p=0.49). ICU referral was necessary in 41 (12.2%) versus 45 (13.2%) (p=0.68) and tracheostomy in 8 (2.4%) versus 9 (2.6%) (p=0.82). Survivors in the methylprednisolone group required a longer median (IQR) hospitalisation (15 (11) versus 14 (11) days; p=0.005) and experienced an improvement in CRP levels, but not in PaO2/FIO2 ratio, at days 7 and 14. There were no differences in disease progression at the prespecified time-points. Conclusion Prolonged, higher dose methylprednisolone did not reduce mortality at 28 days compared with conventional dexamethasone in COVID-19 pneumonia. Infusive methylprednisolone did not show major advantages over conventional dexamethasone in severe COVID-19 pneumonia, confirming the favourable drug class effect of prolonged, low-dose glucocorticoids postulated by current guidelines https://bit.ly/3zxSwMn
p53-mediated metabolic response to low doses of ionizing radiation

Abstract Purpose Unlike treatment with high doses of radiation that causes considerable DNA damage resulting in injury and p53 activation, exposure of cells or whole animals to low doses of radiation (LDR, ∼10cGy) can induce a protective radio adaptive response. Despite ample information about the contribution of the p53 pathway to high doses of radiation-induced effects, our understanding of the role of p53 in LDR-induced response remains incomplete. This review provides a brief summary of the p53 response to LDR exposure focusing on metabolic regulation. Conclusion Consistent with growing evidence indicating a critical role of metabolic pathways in the modulation of stress responses, the radio adaptive response was mediated by the LDR-induced metabolic switch from oxidative phosphorylation to glycolysis. Remarkably, this metabolic reprogramming depends on p53 downregulation, suggesting a previously unrecognized p53-mediated metabolic response. Of note is that the LDR-induced p53 response is temporary but may become persistent if LDR exposure is recurrent and protracted. While further investigation is necessary, the model where LDR induces p53 downregulation concurrent with anabolic reprogramming may offer novel mechanistic insight into the radio adaptive response. It suggests a model in which LDR exposure is protective when transient or intermittent but may become detrimental when chronic because prolonged p53 downregulation would lead to inactivation of this critical tumor suppressor, causing a loss of p53-dependent DNA damage checkpoint, genomic instability, dysregulated metabolism, and thus increased cancer risk.
SOPHIE velocimetry of Kepler transit candidates XVII. The physical properties of giant exoplanets within 400 days of period

While giant extrasolar planets have been studied for more than two decades now, there are still some open questions such as their dominant formation and migration process, as well as their atmospheric evolution in different stellar environments. In this paper, we study a sample of giant transiting exoplanets detected by the Kepler telescope with orbital periods up to 400 days. We first defined a sample of 129 giant-planet candidates that we followed up with the SOPHIE spectrograph (OHP, France) in a 6-year radial velocity campaign. This allow us to unveil the nature of these candidates and to measure a false-positive rate of 54.6 +/- 6.5 % for giant-planet candidates orbiting within 400 days of period. Based on a sample of confirmed or likely planets, we then derive the occurrence rates of giant planets in different ranges of orbital periods. The overall occurrence rate of giant planets within 400 days is 4.6 +/- 0.6 %. We recover, for the first time in the Kepler data, the different populations of giant planets reported by radial velocity surveys. Comparing these rates with other yields, we find that the occurrence rate of giant planets is lower only for hot jupiters but not for the longer period planets. We also derive a first measurement on the occurrence rate of brown dwarfs in the brown-dwarf desert with a value of 0.29 +/- 0.17 %. Finally, we discuss the physical properties of the giant planets in our sample. We confirm that giant planets receiving a moderate irradiation are not inflated but we find that they are in average smaller than predicted by formation and evolution models. In this regime of low-irradiated giant planets, we find a possible correlation between their bulk density and the Iron abundance of the host star, which needs more detections to be confirmed.
Anisotropy in solid inflation

In the model of solid / elastic inflation, inflation is driven by a source that has the field theoretical description of a solid. To allow for prolonged slow roll inflation, the solid needs to be extremely insensitive to the spatial expansion. We point out that, because of this property, the solid is also rather inefficient in erasing anisotropic deformations of the geometry. This allows for a prolonged inflationary anisotropic solution, providing the first example with standard gravity and scalar fields only which evades the conditions of the so called cosmic no-hair conjecture. We compute the curvature perturbations on the anisotropic solution, and the corresponding phenomenological bound on the anisotropy. Finally, we discuss the analogy between this model and the f (phi) F^2 model, which also allows for anisotropic inflation thanks to a suitable coupling between the inflaton phi and a vector field. We remark that the bispectrum of the curvature perturbations in solid inflation is enhanced in the squeezed limit and presents a nontrivial angular dependence, as had previously been found for the f (phi) F^2 model.
Dust ion-acoustic solitary structures in non-thermal dusty plasma

Abstract Dust ion-acoustic solitary structures have been investigated in an unmagnetized non-thermal plasma consisting of negatively charged dust grains, adiabatic positive ions, and non-thermal electrons. Whenever the non-thermal parameter exceeds a critical value, the present system supports negative potential double layer solution. However, this double layer solution is unable to restrict the occurrence of negative potential solitary waves of the present system. As a result, the occurrence of one type of negative potential solitary wave is restricted by Mc < M < MD, whereas the second type of solitary wave exists for all M > MD, where Mc is the lower bound of the Mach number M and MD (> Mc) is the Mach number corresponding to a negative potential double layer. A finite jump between the amplitudes of negative potential solitary waves at M = MD − ϵ1 and M = MD + ϵ2 has been observed, where 0 < ϵ1 < MD − Mc and ϵ2 > 0. Depending on the analytical theory presented in this paper, a numerical scheme has been provided to find the value of the Mach number at which double layer solution exists, and also the amplitude of that double layer. Although the occurrence of coexistence of solitary structures of both polarities is restricted by Mc < M ≤ Mmax, only negative potential solitary wave still exists for all M > Mmax, where Mmax is the upper bound of M for the existence of positive potential solitary waves only. Qualitatively different compositional parameter spaces showing the nature of existing solitary structures of the energy integral have been found. These solution spaces are capable of producing new results and physical ideas for the formation of solitary structures whenever one can move the solution spaces through the family of curves parallel to the curve M = Mc.
Exploratory Analysis of the Sasang Constitution by Combining Network Analysis and Information Entropy

Sasang constitutional medicine is a unique concept in Korean medicine that can provide valuable insights into personalized healthcare and disease treatment. In this study, we combined network analysis and information entropy to systematically investigate the related information of Sasang constitutional (SC) types. A feature network was constructed using SC type and clinical information. The SC type-associated features and feature classes were identified using statistical analysis and entropy ranking. The patient network was constructed based on SC-type-associated features. We found that the feature network was closely connected within the features of the same classes and between several feature class pairs, including the symptom class. Most of the separation values between the feature classes, including the symptom class, were negative. In addition, we found 42 clinical features related to the SC type, and two important classes -personality and cold/heat- that increase the entropy ranking of the SC type. In the patient network, we found sparsely connected modules between SC types and a positive separation value between the Taeeumin–Soeumin and Taeeumin–Soyangin pairs. Our data-driven approach provides a deeper understanding of modernized forms of SC types and suggests that SC type is a practically useful concept for stratified healthcare and personalized medicine.
Stellar Absorption Line Analysis of Local Star-forming Galaxies: The Relation between Stellar Mass, Metallicity, Dust Attenuation, and Star Formation Rate

We analyze the optical continuum of star-forming galaxies in the Sloan Digital Sky Survey by fitting stacked spectra with stellar population synthesis models to investigate the relation between stellar mass, stellar metallicity, dust attenuation, and star formation rate. We fit models calculated with star formation and chemical evolution histories that are derived empirically from multi-epoch observations of the stellar mass–star formation rate and the stellar mass–gas-phase metallicity relations, respectively. We also fit linear combinations of single-burst models with a range of metallicities and ages. Star formation and chemical evolution histories are unconstrained for these models. The stellar mass–stellar metallicity relations obtained from the two methods agree with the relation measured from individual supergiant stars in nearby galaxies. These relations are also consistent with the relation obtained from emission-line analysis of gas-phase metallicity after accounting for systematic offsets in the gas-phase metallicity. We measure dust attenuation of the stellar continuum and show that its dependence on stellar mass and star formation rate is consistent with previously reported results derived from nebular emission lines. However, stellar continuum attenuation is smaller than nebular emission line attenuation. The continuum-to-nebular attenuation ratio depends on stellar mass and is smaller in more massive galaxies. Our consistent analysis of stellar continuum and nebular emission lines paves the way for a comprehensive investigation of stellar metallicities of star-forming and quiescent galaxies.
Probing IGM large-scale flows: warps in galaxies at shells of voids

Context. Hydrodynamical cosmological simulations predict flows of t he intergalactic medium along the radial vector of the voids, approximately in the direction of the infall of matter at the early stages of the galaxy formation. Aims. These flows might be detected by analysing the dependence of t he warp amplitude on the inclination of the galaxies at the shells of the voids with respect to the radial vector of the vo ids. This analysis will be the topic of this paper. Methods. We develop a statistical method of analysing the correlation of the amplitude of the warp and the inclination of the galaxy at the void surface. This is applied to a sample of 97 edge-on galaxies from the Sloan Digital Sky Survey. Our results are compared with the theoretical expectations, which are also derived i n this paper. Results. Our results allow us to reject the null hypothesis (i.e., the non-correlation of the warp amplitude and the inclination of the galaxy with respect to the void surface) at 94.4% C. L. , which is not conclusive. The absence of the radial flows cannot be ex cluded at
Corotation torques experienced by planets embedded in weakly magnetized turbulent discs

The migration of low-mass planets is driven by the differential Lindblad torque and the corotation torque in non-magnetic viscous models of protoplanetary discs. The corotation torque has recently received detailed attention as it may slow down, stall, or reverse migration. In laminar viscous disc models, the long-term evolution of the corotation torque is intimately related to viscous and thermal diffusion processes in the planet's horseshoe region. This paper examines the properties of the corotation torque in discs where MHD turbulence develops as a result of the magnetorotational instability, considering a weak initial toroidal magnetic field. We present results of 3D MHD simulations carried out with two different codes. Non-ideal MHD effects and the disc's vertical stratification are neglected, and locally isothermal disc models are considered. The running time-averaged torque exerted by the disc on a fixed planet is evaluated in three disc models. We first present results with an inner disc cavity (planet trap). As in viscous disc models, the planet is found to experience a positive running time-averaged torque over several hundred orbits, which highlights the existence of an unsaturated corotation torque maintained in the long term in MHD turbulent discs. Two disc models with initial power-law density and temperature profiles are also adopted, in which the time-averaged torque is found to be in decent agreement with its counterpart in laminar viscous disc models with similar viscosity at the planet location. Detailed analysis of the averaged torque density distributions indicates that the differential Lindblad torque takes very similar values in MHD turbulent and laminar viscous discs, and there exists an unsaturated corotation torque in MHD turbulent discs. This analysis also reveals the existence of an additional corotation torque in weakly magnetized discs.
Is 4U 0114+65 an eclipsing HMXB?

We present the pulsation and spectral characteristics of the HMXB 4U 0114+65 during a \emph{Suzaku} observation covering the part of the orbit that included the previously known low intensity emission of the source (dip) and the egress from this state. This dip has been interpreted in previous works as an X-ray eclipse. Notably, in this Suzaku observation, the count rate during and outside the dip vary by a factor of only 2-4 at odds with the eclipses of other HMXBs, where the intensity drops upto two orders of magnitude. The orbital intensity profile of 4U 0114+65 is characterized by a narrow dip in the RXTE-ASM (2-12 \rm{keV}) light curve and a shallower one in the Swift-BAT (15-50 \rm{keV}), which is different from eclipse ingress/egress behaviour of other HMXBs. The time-resolved spectral analysis reveal moderate absorption column density (N$_{H}$ - 2-20 $\times$ $10^{22}$ atoms $cm^{-2}$) and a relatively low equivalent width ($\sim$ 30 \rm{eV} \& 12 \rm{eV} of the iron K$_\alpha$ and K$_\beta$ lines respectively) as opposed to the typical X-ray spectra of HMXBs during eclipse where the equivalent width is $\sim$ 1 \rm{keV}. Both XIS and PIN data show clear pulsations during the dip, which we have further confirmed using the entire archival data of the IBIS/ISGRI and JEM-X instruments onboard \emph{INTEGRAL}. The results we presented question the previous interpretation of the dip in the light curve of 4U 0114+65 as an X-ray eclipse. We thus discuss alternative interpretations of the periodic dip in the light curve of 4U 0114+65.
Acute and Prolonged Effects of Dermal Suction on Joint Range of Motion and Passive Muscle Stiffness: A Preliminary Study

This study aimed to investigate the acute and prolonged effects of dermal suction on joint range of motion (ROM) and passive muscle stiffness. Eight-minute dermal suction was prescribed for the quadriceps femoris in 15 participants. Hip extension ROM, knee flexion ROM, and passive muscle stiffness of the rectus femoris (RF) and vastus lateralis (VL) were measured before and immediately, 30 min, 60 min, 120 min, 24 h, and 48 h after dermal suction. Passive muscle stiffness was measured using shear wave elastography. Hip extension ROM significantly increased immediately (p = 0.032), 60 min (p = 0.029), and 120 min (p = 0.031) after dermal suction compared with before dermal suction; however, it was not significantly different at 30 min, 24 h, and 48 h after dermal suction (p > 0.05). Passive muscle stiffness of the RF and VL and knee flexion ROM did not significantly change at any measurement time compared with before dermal suction (p > 0.05). Our preliminary results suggest that dermal suction improves hip extension ROM immediately after dermal suction of the quadriceps femoris, followed by a return to the pre-prescription level 30 min after. However, the effect was prolonged for 120 min and disappeared before 24 h.