Miracle-dz/UniFAR-FTUs huggingface dataset:
The Effect of Modernization of Tax Administration System, Fiscus Services, Understanding Tax Regulations and Tax Sanctions on The Compliance of Personal Taxpayers (Case Study on Employees of PT Arjuna Maha Sentosa)

This study aims to analyze the modernization of the tax administration system, fiscus services, understanding of tax regulations, and tax sanctions on individual taxpayer compliance through case studies on employees of PT Arjuna Maha Sentosa. This research uses quantitative methods and survey research. The population in this study were employees of PT Arjuna Maha Sentosa. The sampling technique in this study used simple random sampling and obtained a sample of 70 respondents. The data analysis technique uses multiple linear regression and data processing using the SPSS version 26 program. The results show that partially modernization of the tax administration system and understanding of tax regulations have a significant effect on individual taxpayer compliance, while the fiscus services and tax sanctions have no effect on individual taxpayer compliance. Simultaneously all independent variables affect individual taxpayer compliance.
Incursion de fluides dans une zone de cisaillement ductile (Tinos, Cyclades, Grèce) : mécanismes d'infiltration et implications tectoniques

Les domes metamorphiques portent les marques d'un hydrothermalisme intense concomitant de leur exhumation de long de grandes zones de cisaillement crustales. Sur l'exemple du detachement de l'ile de Tinos (Cyclades, Grece), nous proposons une approche qui combine geologie structurale et techniques analytiques de pointe, pour contraindre l'origine et les modalites de circulation des fluides responsables du metasomatisme. Une succession continue de veines metamorphiques, ouvertes durant l'evolution de la deformation depuis le domaine ductile jusqu'au domaine cassant, est identifiee dans le mur du detachement. Chaque stade d'ouverture occasionne la precipitation de quartz et de calcite. Le fractionnement isotopique de l'oxygene des couples quartz-calcite precipites a la transition fragile-ductile, mesure a la sonde ionique, passe de 2 a 5 ‰ dans une frange de 50 m vers la faille, soit une chute de temperature de ~150 °C. Le ? 18O de l'eau en equilibre avec ces couples passe de 15 a 0 ‰ dans cette meme frange. Seules des circulations convectives de fluides surfaciques peuvent expliquer ces variations thermiques et isotopiques. Un profil isotopique realise dans l'ombre de pression d'une pyrite montre une chute brutale du ? 18O de 3 ‰, entre deux maxima. Les inclusions fluides piegees dans des ombres de pression similaires, synchrones du cycle isotopique, montrent une forte fluctuation des isochores de stabilite. Les donnees isotopiques et microthermometriques, qui suggerent une arrivee cyclique de fluides superficiels conjointe a des variations de la pression des fluides, concordent point a point avec les modeles de pompage sismique en domaine ductile inities par la zone sismogenique sus-jacente. Enfin, une comparaison des spectres infrarouge d'inclusions fluides piegees en facies schiste vert et schiste bleu permet d'evaluer les proprietes mouillantes des fluides metamorphiques. A 400 °C, le pic d'absorption des liaisons OH des fluides pieges dans les inclusions schiste bleu est situe a 3475 cm-1, tandis que celui des fluides schiste vert est a 3585 cm-1. Plus fort est le nombre d'onde, plus l'agencement des molecules d'eau est desordonne, occasionnant des tensions d'interface fluide-grain faibles. Les fluides du facies schiste vert ont donc une capacite a connecter la faible porosite des roches metamorphiques tres superieure a celle des fluides schiste bleu, et peuvent infiltrer le mur du detachement en cours d'exhumation, auparavant en systeme clos. Ces interpretations permettent de proposer un modele global de circulation a tous les etages d'un detachement, commande –dans l'ordre de profondeur croissante- par la convection thermique, les cycles sismiques et la migration diffuse. Ce modele synthetique resout le paradoxe qui consiste a introduire des fluides surfaciques -a pression hydrostatique- dans une croute inferieure ductile a pression de pores lithostatique.
Protocol for investigating genetic determinants of posttraumatic stress disorder in women from the Nurses ' Health Study II

Background: One in nine American women will meet criteria for the diagnosis of posttraumatic stress disorder (PTSD) in their lifetime. Although twin studies suggest genetic influences account for substantial variance in PTSD risk, little progress has been made in identifying variants in specific genes that influence liability to this common, debilitating disorder. Methods and design: We are using the unique resource of the Nurses Health Study II, a prospective epidemiologic cohort of 68,518 women, to conduct what promises to be the largest candidate gene association study of PTSD to date. The entire cohort will be screened for trauma exposure and PTSD; 3,000 women will be selected for PTSD diagnostic interviews based on the screening data. Our nested case-control study will genotype1000 women who developed PTSD following a history of trauma exposure; 1000 controls will be selected from women who experienced similar traumas but did not develop PTSD. The primary aim of this study is to detect genetic variants that predict the development of PTSD following trauma. We posit inherited vulnerability to PTSD is mediated by genetic variation in three specific neurobiological systems whose alterations are implicated in PTSD etiology: the hypothalamic-pituitary-adrenal axis, the locus coeruleus/ noradrenergic system, and the limbic-frontal neuro-circuitry of fear. The secondary, exploratory aim of this study is to dissect genetic influences on PTSD in the broader genetic and environmental context for the candidate genes that show significant association with PTSD in detection analyses. This will involve: conducting conditional tests to identify the causal genetic variant among multiple correlated signals; testing whether the effect of PTSD genetic risk variants is moderated by age of first trauma, trauma type, and trauma severity; and exploring gene-gene interactions using a novel gene-based statistical approach. Discussion: Identification of liability genes for PTSD would represent a major advance in understanding the pathophysiology of the disorder. Such understanding could advance the development of new pharmacological agents for PTSD treatment and prevention. Moreover, the addition of PTSD assessment data will make the NHSII cohort an unparalleled resource for future genetic studies of PTSD as well as provide the unique opportunity for the prospective examination of PTSD-disease associations. Published: 29 May 2009 BMC Psychiatry 2009, 9:29 doi:10.1186/1471-244X-9-29 Received: 17 April 2009 Accepted: 29 May 2009 This article is available from: http://www.biomedcentral. com/1471-244X/9/29 © 2009 Koenen et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Design of a placebo-controlled , randomized study of the efficacy of repetitive transcranial magnetic stimulation for the treatment of chronic tinntius

Background: Chronic tinnitus is a frequent condition, which can have enormous impact on patient's life and which is very difficult to treat. Accumulating data indicate that chronic tinnitus is related to dysfunctional neuronal activity in the central nervous system. Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive method which allows to focally modulate neuronal activity. An increasing amount of studies demonstrate reduction of tinnitus after repeated sessions of low-frequency rTMS and indicate that rTMS might represent a new promising approach for the treatment of tinnitus. However available studies have been mono-centric and are characterized by small sample sizes. Therefore, this multi-center trial will test the efficacy of rTMS treatment in a large sample of chronic tinnitus patients. Methods/Design: This is a randomized, placebo-controlled, double-blind multi-center trial of two weeks 1 Hz rTMStreatment in chronic tinnitus patients. Eligible patients will be randomized to either 2 weeks real or sham rTMS treatment. Main eligibility criteria: male or female individuals aged 18–70 years with chronic tinnitus (duration > 6 months), tinnitus-handicap-inventory-score ≥ 38, age-adjusted normal sensorineural hearing (i.e. not more than 5 dB below the 10% percentile of the appropriate age and gender group (DIN EN ISO 7029), conductive hearing loss ≤ 15dB. The primary endpoint is a change of tinnitus severity according to the tinnitus questionnaire of Goebel and Hiller (baseline vs. end of treatment period). A total of 138 patients are needed to detect a clinical relevant change of tinnitus severity (i.e. 5 points on the questionnaire of Goebel and Hiller; alpha = 0.05; 1-beta = 0.80). Assuming a drop-out rate of less than 5% until the primary endpoint, 150 patients have to be randomized to guarantee the target number of 138 evaluable patients. The study will be conducted by otorhinolaryngologists and psychiatrists of 7 university hospitals and 1 municipal hospital in Germany. Discussion: This study will provide important information about the efficacy of rTMS in the treatment of chronic tinnitus. Trial registration: Current Controlled Trials ISRCTN89848288 Published: 15 April 2008 BMC Psychiatry 2008, 8:23 doi:10.1186/1471-244X-8-23 Received: 11 March 2008 Accepted: 15 April 2008 This article is available from: http://www.biomedcentral. com/1471-244X/8/23 © 2008 Landgrebe et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
The 120 0 ordered phase of the spin-1 J 1 – J 2 antiferromagnetic Heisenbeberg model on a triangular lattice

We study the effect of quantum and thermal ﬂuctuations on the excitation energy spectrum and sublattice magnetization of the 120 0 ordered phase of the spin-1 antiferromagnetic Heisenberg model on a triangular lattice with nearest-J 1 and next-nearest-neighbor J 2 exchange interactions. The auxiliary fermionic representation of the spin operators within a functional integral formalism with an imaginary Lagrange multiplier is employed to retain an exact constraint of single particle occupancy. Representing the classical ground state by Luttinger-Tisza ordering vector Q one may consider the ﬂuctuation contributions to the free energy of the system in the entire range of the coupling parameters. We derived the magnon spectrum in one-loop approximation and the magnetization taking into account thermal ﬂuctuations. The obtained results are compared with the result of the linear spin-wave approximation and experimental ﬁndings on compound NiGa 2 S 4 .
The impact of entrepreneurial orientation and company innovation on the business performance of manufacturing SMEs

This study examines the importance of entrepreneurial orientation in relation to innovation and performance within the context of manufacturing small and medium-sized enterprises (SMEs). Additionally, it looks into the impact of innovation on manufacturing SMEs' performance as well as the impact of entrepreneurial innovation on those SMEs' performance. The research population involved all manufacturing SMEs in Gorontalo Province, Indonesia. Sampling processes apply the nonprobability sampling method. The selection of cluster sampling, involving 150 samples, was carried out purposively. Data analysis was carried out using structural equation modeling with software called Analysis of Moment Structures (Amos). The findings indicate a favorable and statistically significant relationship between entrepreneurial orientation and both innovation and performance in manufacturing small and medium-sized enterprises (SMEs). Furthermore, the integration of entrepreneurial orientation and innovation inside small and medium-sized firms (SMEs) operating in the manufacturing sector has been identified as having a substantial and advantageous influence on their overall performance. It is noteworthy that the introduction of innovation within a firm does not have any discernible influence on the operational performance of small and medium-sized enterprises (SMEs) in the manufacturing sector. This study suggests that people involved in manufacturing SMEs must boost their performance by being proactive towards an entrepreneurial orientation. It is recommended for SMEs in Gorontalo City to enhance the implementation of entrepreneurial orientation for the development of their businesses. It is also essential to consider the factors of proactive attitudes, enthusiasm, and risk-taking attitudes.
Long Noncoding RNA ZBED5-AS1 Facilitates Tumor Progression and Metastasis in Lung Adenocarcinoma via ZNF146/ATR/Chk1 Axis

Long noncoding RNAs (lncRNAs) have been implicated in tumorigenesis, including lung adenocarcinoma (LUAD). However, the functional and regulatory mechanisms of lncRNAs in LUAD remain poorly understood. In this study, we investigated the role of lncRNA ZBED5-AS1 in LUAD. We found that ZBED5-AS1 was upregulated in LUAD specimens and overexpressed in LUAD cell lines. ZBED5-AS1 promoted LUAD cell proliferation, migration, and invasion in vitro and promoted LUAD cell growth in vivo. ZBED5-AS1 promoted ZNF146 expression, activating the ATR/Chk1 pathway and leading to LUAD progression. We observed that exosomes from LUAD cells have a higher expression of ZBED5-AS1 compared with exosomes from the normal cell line BEAS-2B. Coculture experiments with exosomes showed that ZBED5-AS1 expression was downregulated after coculture with Si-ZBED5-AS1 exosomes, and coculture with exosomes with low ZBED5-AS1 expression inhibited proliferation and invasion of LUAD cells. Our results indicate that ZBED5-AS1 functions as an oncogenic factor in LUAD cells by targeting the ZNF146/ATR/Chk1 axis.
Organizational and Economic Obstacles to Automation: A Cautionary Tale from AT&T in the Twentieth Century

AT&T was the largest U.S. firm for most of the 20th century. Telephone operators once comprised more than 50% of its workforce, but in the late 1910s, it initiated a decades-long process of automating telephone operation with mechanical call switching—a technology invented in the 1880s. We study what drove AT&T to do so and why it took nearly a century. Interdependencies between call switching and nearly every other activity in AT&T’s business presented obstacles to change: Telephone operators were the fulcrum of a complex production system that had developed around them, and automation only began after the firm and new technology were adapted to work together. Even then, automatic switching was only profitable in larger markets—hence, diffusion expanded when the technology improved or service areas grew. The example suggests even narrowly defined tasks can be difficult to automate if they interact with many others. This paper was accepted by Joshua Gans, business strategy. Funding: The authors thank the Duke University Fuqua School of Business and Harvard Business School Division of Research and Faculty Development for financial support. Supplemental Material: The online appendices and data files are available at https://doi.org/10.1287/mnsc.2022. 01760 .
Biomaterials combined with ADSCs for bone tissue engineering: current advances and applications

Abstract In recent decades, bone tissue engineering, which is supported by scaffold, seed cells and bioactive molecules (BMs), has provided new hope and direction for treating bone defects. In terms of seed cells, compared to bone marrow mesenchymal stem cells, which were widely utilized in previous years, adipose-derived stem cells (ADSCs) are becoming increasingly favored by researchers due to their abundant sources, easy availability and multi-differentiation potentials. However, there is no systematic theoretical basis for selecting appropriate biomaterials loaded with ADSCs. In this review, the regulatory effects of various biomaterials on the behavior of ADSCs are summarized from four perspectives, including biocompatibility, inflammation regulation, angiogenesis and osteogenesis, to illustrate the potential of combining various materials with ADSCs for the treatment of bone defects. In addition, we conclude the influence of additional application of various BMs on the bone repair effect of ADSCs, in order to provide more evidences and support for the selection or preparation of suitable biomaterials and BMs to work with ADSCs. More importantly, the associated clinical case reports and experiments are generalized to provide additional ideas for the clinical transformation and application of bone tissue engineering loaded with ADSCs.
Computational Fluid Dynamics Investigation of Chronic Aortic Dissection Hemodynamics Versus Normal Aorta

Objectives: To evaluate hemodynamic changes during aneurysmal dilatation in chronic type B aortic dissections compared to hemodynamic parameters in the healthy aorta with the use of computational fluid dynamics (CFD). Methods: True lumen (TL)/false lumen (FL) dimensional changes, changes in total pressure (TP), and wall shear stress (WSS) were evaluated at follow-up (FU) compared to initial examination (IE) with transient CFD simulation with geometries derived from clinical image data and inflow boundary conditions from magnetic resonance images. The TL/FL pressure gradient between ascending and descending aorta (DAo) and maximum WSS at the site of largest dilatation was compared to values for the healthy aorta. Results: Hemodynamic changes at site of largest FL dilatation included 77% WSS reduction and 69% TP reduction. Compared to the healthy aorta, pressure gradient between ascending and DAo was a factor of 1.4 higher in the TL and a factor of 1.5 in the FL and increased at FU (1.6 and 1.7, respectively). Maximum WSS at the site of largest dilatation was a factor of 3 lower than that for the healthy aorta at IE and decreased by more than a factor of 2 at FU. Conclusions: The FL dilatation at FU favorably reduced TP. In contrast, unfavorable increase in pressure gradient between ascending and DAo was observed with higher values than in the healthy aorta. Maximum WSS was reduced at the site of largest dilation compared to healthy aorta.
The Impact of Competition from Venture Capitalists on Corporate Venturing Investment

This study proposes a model on corporate venturing (CV) investment and examines the impact of venture capital (VC) activity in the economy on CV firms’ investment. The presence of VCs creates competition for entrepreneurs. This reduces CV firms’ expected v enturing returns, and thus gives rise to a financial disincentive to CV investment. The empirical prediction of this result is that competition for talent should decrease CV investment. This prediction contradicts previous statements in the theoretical literature on CV.
Hydrogen sulphide and other factors influencing the macrobenthic community structure in the Gulf of Gdansk

Three stations in the Gulf of Gdańsk were sampled monthly for one year with regard to macrozoobenthos composition, oxygen content and temperature of near-bottom waters, granulometry, organic matter content and H2S concentration in sediments. The differences in H2S concentrations at the stations were most conspicious. The presence and concentrations of H2S appeared to be the decisive factor for the grouping of samples in the Bray-Curtis Similarity Index-based ordination. Even seasonality was of secondary importance. The number of species and the Shannon Indices decreased, and the dominance of the predominant species – Macoma balthica – increased in accordance with the H2S gradient between the stations. The community was dominated by detritus-feeders.
Perceptions of the Built Environment and Associations With Walking Among Retirement Village Residents

Housing options, such as retirement villages, that promote and encourage healthy behaviors are needed to accommodate the growing older adult population. To examine how environmental perceptions relate to walking, residents of retirement villages in Perth, Australia, were sampled, and associations between a wide range of village and neighborhood environmental attributes and walking leisurely, briskly, and for transport were examined. Perceived village features associated with walking included aesthetics (odds ratio [OR] = 1.72), personal safety (OR = 0.43), and services and facilities (OR = 0.80), whereas neighborhood attributes included fewer physical barriers (OR = 1.37) and proximate destinations (OR = 1.93). Findings suggest that locating retirement villages in neighborhoods with many local destinations may encourage more walking than providing many services and facilities within villages. Indeed, safe villages rich with amenities were shown to be related to less walking in residents. These findings have implications for the location, design, and layout of retirement villages.
Recent Advancements and Future Prospects in Active Deep Learning for Medical Image Segmentation and Classification

Medical images are helpful for the diagnosis, treatment, and evaluation of diseases. Precise medical image segmentation improves diagnosis and decision-making, aiding intelligent medical services for better disease management and recovery. Due to the unique nature of medical images, image segmentation algorithms based on deep learning face problems such as sample imbalance, edge blur, false positives, and false negatives. In view of these problems, researchers primarily improve the network structure but rarely improve from the unstructured aspect. The paper tackles these challenges, accentuating the limitations of deep convolutional neural network-based methods and proposing solutions to reduce annotation costs, particularly in complex images, and introduces the improvement strategies to solve the problems of sample imbalance, edge blur, false positives, and false negatives. Additionally, the article introduces the latest deep learning-based applications in medical image analysis, covering segmentation, image acquisition, enhancement, registration, and classification. Moreover, the article provides an overview of four cutting-edge deep learning models, namely convolutional neural network (CNN), deep belief network (DBN), stacked autoencoder (SAE), and recurrent neural network (RNN). The study selection involved searching benchmark academic databases, collecting relevant literature and appropriate indicator for analysis, emphasizing DL-based segmentation and classification approaches, and evaluating performance metrics. The research highlights clinicians’ and scholars’ obstacles in developing an efficient and accurate malignancy prognostic framework based on state-of-the-art deep-learning algorithms. Furthermore, future perspectives are explored to overcome challenges and advance the field of medical image analysis.