Miracle-dz/UniFAR-FTUs huggingface dataset:
HSOA Journal of Vaccines Research and Vaccination Research Article Are We Vaccinating Immunocompetent or Immunocompromised People for COVID 19?

Introduction: Since January 2020, Chinese scientists shared the SARS-CoV-2 genomic sequence and approximately, 321 research groups begin the search for vaccine since then. The CDC notes that immunocompromised patients may receive the vaccines so long as they have no contraindications to vaccination, but that they should be counseled about the unknown safety profiles of the vaccines in immunocompromised populations. Purpose: The purpose of this study is to demonstrate that the majority of the patients that the author is attending nowadays is in the category of immune compromised patients. Methods: The author did radiesthesia procedure to measure the energy of the seven chakra of 1000 patients during 2015 to 2020. Doing this measurement, the author was measuring the energy of the five massive organs in traditional Chinese medicine, responsible for the production of energy Yin, Yang, Qi and Blood, important to maintenance of health and the immune system in the human body and the production of Zheng-Qi , that is responsible for the protection of the body against the invasion of external pathogenic factor, in this case SARS-CoV-2. Results: The result of this study is that more than 97 percent of the patients analyzed were in the lowest level of energy, meaning that their immune system are compromised because energy in TCM means immune system. Conclusion: The conclusion of this study is that we are vaccinating immunecompromised people and not immunecompetent for COVID 19. In the group of patients studied by the author, more than 90% of the patients have no energy in the chakras’ energy centers that corresponds to no energy in the five massive organs in traditional Chinese medicine, responsible for the production of Yin, Yang, Qi and Blood to maintenance of health and immune system.
The feasibility of Kimny guiding catheter for ST-segment elevation myocardial infarction

Objectives: The Kimny guiding catheter is a single universal guiding catheter used for performing percutaneous coronary intervention (PCI) in both the right coronary artery (RCA) and the left coronary artery (LCA). Although this guiding catheter has been shown to yield high procedural success rates in nonemergent conditions, its feasibility for patients with ST-segment elevation myocardial infarction (STEMI) remains unknown and therefore needs to be further investigated. Materials and Methods: We retrospectively enrolled 62 consecutive STEMI patients who underwent primary PCI using the Kimny guiding catheter from January 2016 through December 2017. We then evaluated the rates of engagement and procedural success for PCI of the LCA and RCA with the Kimny guiding catheter. Results: Primary PCI of the infarct-related artery (IRA) by means of the Kimny guiding catheter proved to be successful in 61 of the STEMI patients (98.3%). Besides, the procedural success rate was found to be 100% (44/44) for the LCA and 94.4% (17/18) for the RCA (P = 0.293). With regard to contralateral (non-IRA) angiography, engagement rates of 97.4% (38/39) and 100% (18/18) were obtained for the RCA and LCA, respectively, (P = 1.0). No coronary artery ostial dissection was observed during the procedures. The mean number of total catheters used for each patient turned out to be only 1.035. Conclusion: Using the Kimny guiding catheter for primary PCI is feasible and results in high procedural success rates, particularly for the treatment of the LCA, with fewer catheters, and at a lower cost.
Headless Relative Clauses in Mesoamerican Languages

This volume presents the collective work of a team of twenty-one scholars who have investigated headless relative clauses in fifteen languages from five language families—all Mesoamerican but one. Headless relative clauses have received little attention in the linguistic literature, despite the many morpho-syntactic and semantic puzzles they raise within and across languages and for our understanding of human language in general. Headless relative clauses have been even more neglected in the study of Mesoamerican languages. This volume constitutes the first in-depth, systematic study of headless relative clauses for any Mesoamerican languages we know of, and the broadest and most articulated crosslinguistic study of headless relative clauses that has been conducted so far. For most of the languages in this volume, there is no descriptive or documentary material on wh-constructions in general, let alone headless relative clauses. Many of the languages are threatened or endangered; all are understudied. All of the chapters constitute original contributions to typological and theoretical linguistics. The first chapter introduces and defines the varieties of headless relative clauses that are investigated in the other chapters, compares them to two related and better-known constructions, namely headed relative clauses and wh- interrogative clauses, summarizes the main findings in a comparative prospective, highlights the importance of studying headless relative clauses to understand human language, and provides a methodological framework for the other chapters and future work. All the other chapters are language-specific and follow a uniform format to facilitate comparisons and generalizations across languages.
Small Fixed-Point Cells for Use in Dry Well Block Calibrators

As part of a research project for the Combined Calibration Group (CCG) of the U.S. Armed Forces, three rugged fixed-point cells were developed for use in dry well block calibrators (DWBCs). The small fixed-point cells of the water triple point (0.01 °C), the Ga melting point (29.7646 °C), and the In melting point (156.5985 °C) are intended to provide either calibration temperature points for industrial platinum resistance thermometers (IPRTs) or single-point calibration checks on IPRTs for the CCG mobile calibration facilities. While the ITS-90 indium fixed point is defined as a freezing point, realization of the three fixed-point cells in the melting mode simplifies the realization process, yet still provides the required expanded uncertainty (k=2) of less than 10 m°C. These three fixed-point cells were tested in two DWBCs using standard platinum resistance thermometers (SPRTs) by measuring realization plateaus and by direct comparisons with the PRT Laboratory reference cells. Adequacy of immersion of the thermometers in the cells during realization of the fixed points in the DWBCs was checked and the results were used to quantify the immersion uncertainty. This paper presents the realization methods, behavior of the fixed-point cells in the DWBCs and the uncertainty assigned to each of cells.
EFFECT OF DIFFERENT SOLVENTS ON THE CHEMICAL COMPOSITION AND ANTI-DIABETIC ACTIVITY OF ACACIA ARABICA AND ZIZYPHUS MAURITIANA

The current study was designed to investigate the effect of solvents on chemical composition and antidiabetic activity of Zizyphus mauritiana and Acacia Arabica extracts. Total five solvents were used for this purpose (100% methanol, 50% aqueous methanol, 100% ethanol, 50% aqueous ethanol and aqueous). The data obtained from the investigation was subjected to the statistical analysis by using analysis of variance technique. The present study revealed that maximum antioxidant activity was attributed to Acacia arabica (96.53 ± 0.46%) followed by Zizyphus mauritiana (94.33 ± 0.52% by 50% aqueous ethanol extracts). Maximum total phenolic content of both Zizyphus mauritiana and Acacia arabica (670.83 ± 1.46 mg GAE/100g and 934.34 ± 0.89 mg GAE/100g) were shown by 50% aqueous ethanol extracts while maximum total flavonoid content (146.36 ± 0.81 mg QE/100 g, 172.52 ± 0.99 mg QE/100 g) was exhibited by 50% aqueous ethanol extract. The maximum (IC 50= 49.63 ± 0.12 µg/mL) antidiabetic activity was found in aqueous extract of Acacia arabica while in Zizyphus mauritiana the aqueous extract indicated excellent (IC 50= 46.90 ± 0.23 µg/mL) antidiabetic activity.
Room‐Temperature Fabricated Amorphous Ga2O3 High‐Response‐Speed Solar‐Blind Photodetector on Rigid and Flexible Substrates

A solution to the fabrication of amorphous Ga2O3 solar‐blind photodetectors on rigid and flexible substrates at room temperature is reported. A robust improvement in the response speed is achieved by delicately controlling the oxygen flux in the reactive radio frequency magnetron sputtering process. Temporal response measurements show that the detector on quartz has a fast decay time of 19.1 µs and a responsivity of 0.19 A W−1 as well, which are even better than those single crystal Ga2O3 counterparts prepared at high temperatures. X‐ray photoelectron spectroscopy and current–voltage tests suggest that the reduced oxygen vacancy concentration and the increased Schottky barrier height jointly contribute to the faster response speed. Amorphous Ga2O3 solar‐blind photodetector is further constructed on polyethylene naphthalate substrate. The flexible devices demonstrate similar photoresponse behavior as the rigid ones, and no significant degradation of the device performance is observed in bending states and fatigue tests. The results reveal the importance of finely tuned oxygen processing gas in promoting the device performance and the applicability of room‐temperature synthesized amorphous Ga2O3 in fabrication of flexible solar‐blind photodetectors.
Synthesis and Oxidizability Study on Mn3O4 Nanoparticles

Sphere-like Mn3O4 nanoparticles were prepared by a simple aqueous precipitation method at 30 °C for 1.5 h with PEG 6000 involved. The as-prepared Mn3O4 nanoparticles extended sphere-like structures with sizes of around 80 nm. The size and shape could be manipulated by changing the species of alkali. Introduction of PEG6000 in the experiments caused the inhibition of crystal growth. The oxidiability of as-prepared Mn3O4 nanoparticles was evaluated by degradation of rhodamine B (RhB). The pH value of the reaction system was major factors to be assessed in the degradation process. After 120 minutes’ reaction, the degradation efficiency can reach 61.3 %.
Substrate Binding Induces Conformational Changes in a Class A β-lactamase That Prime It for Catalysis

The emergence and dissemination of bacterial resistance to β-lactam antibiotics via β-lactamase enzymes is a serious problem in clinical settings, often leaving few treatment options for infections resulting from multidrug-resistant superbugs. Understanding the catalytic mechanism of β-lactamases is important for developing strategies to overcome resistance. Binding of a substrate in the active site of an enzyme can alter the conformations and pKas of catalytic residues, thereby contributing to enzyme catalysis. Here we report X-ray and neutron crystal structures of the class A Toho-1 β-lactamase in the apo form and an X-ray structure of a Michaelis-like complex with the cephalosporin antibiotic cefotaxime in the active site. Comparison of these structures reveals that substrate binding induces a series of changes. The side chains of conserved residues important in catalysis, Lys73 and Tyr105, and the main chain of Ser130 alter their conformations, with Nζ of Lys73 moving closer to the position of the con.
Serum metabolomics strategy for understanding the therapeutic effects of Yin-Chen-Hao-Tang against Yanghuang syndrome

Yin-Chen-Hao-Tang (YCHT), a classic Chinese herbal formula, is characterized by its strong therapeutic effects of liver regulation and relief of jaundice, especially Yanghuang syndrome (YHS). YHS is a type of jaundice with damp-heat pathogenesis, and it is considered a complicated Chinese medicine syndrome (CMS). The accurate mechanism for healing YHS has not yet been completely reported. The purpose of the current research is to investigate the expression of endogenous biomarkers in YHS mice and evaluate the clinical therapeutic effect of YCHT. Serum samples were analyzed using UPLC-Q/TOF-MS techniques in order to determine differential metabolites to elucidate the functional mechanism of YCHT on YHS through metabolite profiling combined with multivariate analysis. Simultaneously, the exact diversification of YHS mice was elucidated using blood biochemistry indexes and histopathological examination, and the results indicated that YHS is markedly improved by YCHT. Unsupervised principal component analysis (PCA) patterns were constructed to dissect the variances of metabolic profiling. Overall, 22 potential biomarkers were identified using a metabolomics approach based on an accurate MS/MS approach, clustering and distinguishing analysis. The present work demonstrates that the effectiveness of YCHT against YHS prompts distinct discrepancies in metabolic profiles by adjusting biomarkers and regulating metabolic disorders. A total of 15 metabolic pathways were involved in biological disturbance. This demonstrates that metabolomic techniques are powerful means to explore the pathogenesis of CMS and the therapeutic effects of traditional Chinese formulae.
Modulation of intracellular ATP influences seizure activity via the activity-dependent release of adenosine

A large number of patients with epilepsy have drug-resistant seizures. Therefore, there is a need for the development of new therapies. The purine nucleoside adenosine is an endogenous anticonvulsant that acts to supress neuronal excitability via adenosine A1 receptors. The aim of this thesis was to investigate whether manipulating ATP bioenergenetics and importantly adenosine levels had any effects on activity-dependent release of adenosine and seizure activity. ATP bioenergetics and adenosine levels were manipulated by pre-treating rat hippocampal slices with a combination of the sugar backbone of ATP (D-ribose) and the free purine base adenine (RibAde) and the phosphate buffer creatine. The role that the adenosine A2A receptor plays in relation to epileptiform activity was also investigated. Biosensors were used to measure the real-time release of adenosine. The K+ channel blocker 4-aminopyridine (4-AP; 50 μM) in Mg2+-free medium was the model used for inducing spontaneous bursting epileptiform activity. Additionally, homocysteine thiolactone (HTL) was used to “trap” intracellular adenosine to test if extracellular adenosine measured with biosensors, is released as adenosine per se and if this had any effects on seizure activity. I show that during bursting epileptiform activity, the amount of adenosine released is increased in RibAde slices compared to creatine and untreated (control) slices and increased the time between seizures compared to both creatine and control slices. No differences was found between creatine and control slices. My data also suggest that adenosine A2A receptors may partially contribute to seizure activity. HTL reduced adenosine release in a burst-dependent manner and also increased the frequency of seizures. HTL influenced the intensity of bursts in control but not RibAde-treated slices. This thesis provides evidence for the beneficial role of the ATP precursors ribose and adenine on reducing seizure activity and will hopefully contribute to ongoing attempts to establish adenosine-based epilepsy therapies.
Teaching Indigenous Science Curriculum to Filipino Kindergarten Learners

This is a narrative result of a study on teaching indigenous Science for kindergarten in the Philippines. The researcher observed and analyzed the learners’ behavior and interaction to know the effect of teaching indigenous Science in kindergarten. The result showed that teaching indigenous Science enables the learners to (1) relate personal experiences to several Science concepts and skills; (2) exhibit genuine creativity; and (3) convey observations and ideas freely and accurately by using the local language as medium of instruction. The study also observed certain characteristics of kindergarten learners from indigenous communities and several indigenous teaching methods that can enhance the teaching and learning process in kindergarten. This study strongly advocates the development and teaching of an indigenous Science curriculum as a creative approach for designing a relevant and effective Science curriculum for culturally diverse learners.
Improvement of energy-momentum tensor and non-Gaussianities in holographic cosmology

In holographic models of cosmology based on the (A)dS/CFT correspondence, conformal symmetry is implicit in the dual description of the Universe. Generically, however, one cannot expect the (broken) conformal invariance in the cosmic fluctuations as only the scale invariance is manifest in experiments. Also, in order for the prediction of the holographic models to make sense, the conformal symmetry needs to be broken as the scalar mode of the metric fluctuations becomes pure gauge in the conformal limit. We discuss the improvement ambiguity of the energy-momentum tensor in this context and construct a holographic model of the Universe that preserves the scale invariance but not necessarily the full conformal invariance. Our sample computation using a weakly coupled dual field theory shows that the orthogonal type of non-Gaussianity is present over and above the equilateral type. The improvement ambiguity corresponds to the choice of the energy momentum tensor that will couple to our particle physics sector after inflation. Our results show that the holographic prediction of the cosmological parameters crucially depends on such a choice.
"Uncertainty in the Movies: Does Star Power Reduce the Terror of the Box Office?"

Everyone knows that the movie business is risky. But how risky is it? Do strategies exist that reduce risk? We investigate these questions using a sample of over 200 motion pictures. We discover that the movies are very risky indeed. Box-office revenues are asymptotically Pareto-distributed and have infinite variance. The mean is dominated by rare blockbuster movies that are located in the far right tail. There is no typical movie because box-office revenue outcomes do not converge to an average, they diverge over all scales.
Effects of Exhaustible Resources and Declining Population on Economic Growth with Hotelling's Rule

This study introduces declining population and exhaustible resources into a semi-endogenous growth model that explicitly incorporates firms' optimization behavior and investigates the relationship between the population growth rate and the growth rate of the per capita output. The main results are as follows. First, irrespective of whether the population growth rate is positive or negative, the long-run growth rate of per capita output can be positive, depending on the conditions. Second, when the population growth rate is positive, the long-run growth rate of per capita output depends positively on the saving rate, although the model belongs to the class of semi-endogenous growth without scale effects.
Effects of ultrasound treatment and concentration of ethanol on selectivity of phenolic extraction from apple pomace

The extraction of polyphenols from apple pomace was studied using ultrasound, ethanol/water mixtures and moderate temperatures, 20–37 °C. The extraction kinetics and extraction yields of catechin and total phenolic content (TPC) were evaluated at different times of ultrasound treatment (tᵤ) and concentrations of ethanol (Cₑ). The highest extraction efficiency of TPC was observed at tᵤ = 30 min, Cₑ = 50% and total extraction time of tₑ = 60 min. The high selectivity of catechin extraction was demonstrated by analysing the relative content of catechin (R = Cc/TPC) in dependence of applied extraction protocol. The initial portions of extracts at small levels of TPC (≤50 mg per 100 DM) were richer in catechin content (R ≈ 15%–31%), whereas the last portions of extracts with high level of TPS were more exhausted in catechin (R ≈ 2%).
Combined Use of Zero Valent Iron and Magnetic Separation for ex-situ Removal of Bioavailable Metals from Contaminated Sediments

ABSTRACT Sandy and organic sediments characterized by different heavy metal binding capacities (HMBC), and contaminated with Copper (Cu), mercury (Hg), or zinc (Zn) were treated ex-situ using a remediation approach consisting of (i) sorption onto oxidized zero-valent iron (ZVI) surfaces and (ii) retrieval of formed metal-ZVI complexes from sediment matrices by magnetic separation. The research focused on the reduction/elimination of the bioavailable fractions of metals, and the efficiency of the method assessed by a combination of a bacterial (MetPLATE™) and an invertebrate (the 48-h Ceriodaphnia dubia acute toxicity test) based bioassays. In sandy sediments, characterized by low HMBC (20.8, 23.5, and 39.6 for Hg, Cu, and Zn, respectively), the determined toxicity units (TU) prior to sediment treatment increased in the order Hg < Cu < Zn, regardless of the bioassay used. The use of ZVI and magnetic separation in these sandy sediments resulted in up to 97% TU reduction. In organic-rich sediments, the affinity of the studied metals for organic matter (OM) resulted in much higher HMBC values (83.9, 108.3, and 136.2 for Cu, Zn, and Hg, respectively) and much lower TU values before sediment treatment with ZVI. The use of MetPLATE™ on non-treated sediments resulted in TU values increasing in the order Hg < Cu < Zn, with TU removal efficiencies ranging from 83% to 97% after treatment. The TU values measured with the 48-h C. dubia assay were higher than those obtained with MetPLATE™, and in this case, sediments contaminated with Zn exhibited the lowest percentage of TU removal, with only 81.7% and 80.5% TU removal for sediments with contamination levels of 400 and 800 mg/kg, respectively. For organic sediments contaminated with Cu and Hg, the TU removal exceeded 95%. Overall, this study showed that the proposed remediation method has great potentials with regard to the elimination of the bioavailable metal fractions in contaminated sediments. GRAPHICAL ABSTRACT
CO2 abatement using two-dimensional MXene carbides

Two-dimensional transition metal carbides with a formula of M2C (M = Ti, Zr, Hf, V, Nb, Ta, Cr, Mo, W) have been recently synthesized and isolated, and are here presented as very promising candidates for carbon dioxide (CO2) capture, storage, and activation. By means of density functional theory investigations including dispersion we show the strong CO2 uptake and activation on M2C compounds, where the estimates of adsorption and desorption rates indicate their CO2 adsorption capacity even at low CO2 partial pressures and high temperatures. The M2C compounds feature noteworthy CO2 loading capacities ranging from 2.34 to 8.25 mol CO2 kg−1, making them practical materials for CO2 abatement.
Work Engagement and Organizational Commitment in Private University

: Work engagement and organizational commitment have an important role in organization. The purpose of this research is to study closely the existency of correlation between work engagement and organizational commitment. The research was conducted at a private university in West Jakarta, Indonesia. We had 124 participants, namely: 67 lecturers and 57 non-academic employees. The method measurement we used were UWES-17 for measuring the work engagement scale and OCQ for the Organizational Commitment Questionnaire Scale. We also used partial correlation techniques with the aid of SPSS 22 to analyze the correlation between work engagement and organizational commitment. The result of research shows that there is a positive and significant correlation between work engagement and organizational commitment.