Miracle-dz/UniFAR-FTUs huggingface dataset:
Corporate Social Responsibilities of Tourism Enterprises and Its Effects on Frontline Employees

As one of the micro-level contents of sustainable development, corporate social responsibility is the most effective method for tourism enterprises to support sustainable tourism. Studying the impact of tourism corporate social responsibility on the service behavior of frontline employees will help maintain the stability of the frontline employee of tourism enterprises and improve the competitiveness of tourism enterprises. This study builds a research model, proposes research hypotheses, and uses 405 valid data to conduct empirical research on the issue. The results show that tourism corporate social responsibility has a positive impact on the pro-social motivation and tourism service improvisation of frontline employees, and pro-social motivation also has a positive impact on tourism service improvisation. In addition, pro-social motivation plays a partial mediating role in the relationship between corporate social responsibility and tourism service improvisation. Finally, this study provides a reference and a new theoretical perspective for the management and research of tourism enterprises in the context of the epidemic.
The Effect of Resveratrol on Cellular Senescence in Normal and Cancer Cells: Focusing on Cancer and Age-Related Diseases

Abstract Cellular senescence is generally defined as irreversible cell-cycle arrest and loss of replicative capacity in virtually all cell types which can have effects on tissues and possibly play a significant role in promoting age-related chronic diseases and cancers. Recently, use of natural bioactive substances such as resveratrol to modify the process of cellular senescence in tissue cells based on specific context has opened an interesting therapeutic perspective in aging and chronic diseases such as cancers. This natural polyphenol is currently being evaluated as a promising anticancer and anti-age-related disease agent. Resveratrol modulates cell cycles and multiple pathways involved in cell growth, apoptosis, senescence, and inflammation, which has mostly observed in laboratory models. In vitro studies indicate that biological effects of resveratrol on cellular senescence or other cell processes may vary depending on cell types and certain contexts. This review aims to discuss the current body of knowledge on the effects of resveratrol on cellular senescence in cancerous and normal cells and its possible effect on prevention of cancers and aging based on in vitro and in vivo studies. It also deals with the putative mechanisms underlying these effects of resveratrol and propounds the controversy on this topic.
Patient Perspectives on the Meaning and Impact of Fatigue in Hemodialysis: A Systematic Review and Thematic Analysis of Qualitative Studies.

RATIONALE & OBJECTIVE Fatigue is a highly prevalent and debilitating symptom in patients on hemodialysis therapy due to the uremic milieu, the hemodialysis treatment itself, and other comorbid conditions. However, fatigue remains underrecognized and the consequences are underappreciated because it may not be visible in clinical settings. This study aims to describe the experience that patients undergoing maintenance hemodialysis have with fatigue. STUDY DESIGN Systematic review and thematic synthesis of qualitative studies. SETTING & STUDY POPULATIONS Patients undergoing hemodialysis. SEARCH STRATEGY & SOURCES MEDLINE, Embase, PsycINFO, CINAHL, reference lists, and PhD dissertations were searched from inception to October 2018. DATA EXTRACTION All text from the results/conclusion of the primary studies. ANALYTICAL APPROACH Thematic synthesis. RESULTS 65 studies involving 1,713 participants undergoing hemodialysis were included. We identified 4 themes related to fatigue: debilitating and exhausting burden of dialysis (bodily depletion, trapped in a vicious cycle of postdialysis exhaustion, vigilance and worry inhibiting rest, tiresome and agonizing regimen, and without remedy and relief), restricted life participation (deprived of time, managing energy reserves, frustrating need to rest, and joys foregone), diminishing capacities to fulfil relationship roles (losing ability to work and provide for family, failing as a parent, lacking stamina for sexual intimacy, and relying on others), and vulnerable to misunderstanding (being criticized for the need to rest and failing to meet expectations). LIMITATIONS Non-English articles were excluded and most studies were conducted in high-income countries. CONCLUSIONS For patients undergoing hemodialysis who experience fatigue, fatigue is a profound and relentless exhaustion that pervades the entire body and encompasses weakness. The fatigue drains vitality in patients and constrains their ability to do usual activities and fulfill their roles and meet personal aspirations. Explicit recognition of the impact of fatigue and establishing additional effective interventions to improve fatigue are needed.
Different word-learning contexts alter phonotactic rule learning in 6-month-olds

ABSTRACT Context can affect language processing and learning. We here compare the influence of two different contexts (pseudo-objects, data from [Obrig, H., Mock, J., Stephan, F., Richter, M., Vignotto, M., & Rossi, S. (2017). Impact of associative word learning on phonotactic processing in 6-month-old infants: A combined EEG and fNIRS study. Developmental Cognitive Neuroscience, 25, 185–197. https://doi.org/10.1016/j.dcn. 2016.09. 001] , vs. real objects) on the processing of phonotactically legal vs. illegal pseudowords (PW) in a 3-day learning paradigm in 6-month-olds. Using ERPs and functional Near InfraRed Spectroscopy (fNIRS) we find that short-term (pre-→post-test) and long-term (day1→ day2→day3) attunement to pseudowords is affected by both, learning context and phonotactic status. When real objects are used, fNIRS shows a long-term increase in response magnitude for legal PW. ERPs show a long-term decrease in negativities in response to trained legal PW. Conversely, the pseudo-objects context elicits neuronal attunement to all PW. We propose that legal PW in a real object context cause conflict, leading to difficulties in lexical integration. However, training eases lexical integration of trained legal PW through priming. Our results speak for the early relevance of phonotactics and context in language acquisition.
Susceptibility of several cotton varieties to the cotton flea beetle, Podagrica puncticollis Weise (Coleoptera: Chrysomelidae), in a hot dry tropical environment of Ethiopia

Field trials were conducted to determine the susceptibility of cotton varieties to infestation of cotton flea beetle, Podagrica puncticollis Weise (Coleoptera: Chrysomelidae). The experiment was carried out using twelve cotton varieties. The results showed significant differences among varieties in the populations of adult beetle they hosted and the injury they sustained 15, 22, 29, 36 and 43 days after sowing (DAS). Fifteen DAS, the highest number of adult beetle per plant (6.3), percent leaf area damaged (60.32 %) and number of shot-holes per attacked leaf (53.4) were recorded in Cucurova variety, whereas the lowest in Bulk-202 (2.05 beetles, 26.15% leaf area damaged and 23.16 shot-holes). The rate of incidence and damages decreased with the increase of the age of the cotton plants. The results showed significant differences among cotton varieties in some agronomic characteristics i.e. in number of plants counted per plot at harvest and seed cotton yield. Based on these findings, Cucurova, Local, Ionia and Acala SJ-2 varieties showed highly susceptible response, while Candia, Sille-91 and Deltapine-90 were moderately susceptible to cotton flea beetle. Bulk-202, Delcero and Claudia were the most tolerant varieties followed by CCRI-12 and Cuokra. These results will be valuable in the selection of cotton varieties to be used in areas where cotton flea beetle occurs.
In‐Hospital Bleeding Outcomes of Myocardial Infarction in the Era of Warfarin and Direct Oral Anticoagulants for Atrial Fibrillation in the United States: A Report From the National Cardiovascular Data Registry Acute Coronary Treatment and Intervention Outcomes Network Registry

Background We sought to examine patient characteristics, peri‐infarction invasive and pharmacologic management, and in‐hospital major bleeding in myocardial infarction patients with atrial fibrillation or flutter, based on home anticoagulant use. Methods and Results We stratified patients by home anticoagulant: (1) no anticoagulant, (2) warfarin, and (3) direct oral anticoagulants (DOACs) among ST‐segment–elevation myocardial infarction (STEMI) and non‐STEMI (NSTEMI) patients with atrial fibrillation or flutter treated at 761 US hospitals in the ACTION (Acute Coronary Treatment and Intervention Outcomes Network) Registry from January 2015 to December 2016. The primary outcome of our study was in‐hospital major bleeding. Multivariable logistic regression was used to examine the independent association between home anticoagulant and in‐hospital major bleeding. Among 6471 STEMI patients with atrial fibrillation or flutter, 15.7% were on warfarin and 13.0% on DOACs; among 19 954 NSTEMI patients, 22.8% were on warfarin and 15.4% on DOACs. In STEMI, door‐to‐balloon times were slightly higher in those on anticoagulant, with similar rates of angiography within 24 hours in the 3 groups. NSTEMI patients on anticoagulant were less likely to undergo angiography (49.3% no anticoagulant, 33.4% on warfarin, 36.4% on DOACs; P<0.01) or percutaneous coronary intervention within 24 hours (21.1% no anticoagulant, 14.3% on warfarin, 15.9% on DOACs; P<0.01). After multivariate adjustment, use of home warfarin (odds ratio: 1.00 [95% CI, 0.79–1.27] in STEMI and 1.13 [95% CI, 0.97–1.30] in NSTEMI) or DOAC (odds ratio: 0.93 [95% CI, 0.73–1.20] in STEMI and 0.97 [95% CI, 0.81–1.16] in NSTEMI) was not associated with increased in‐hospital major bleeding compared with no anticoagulant. Conclusions In routine clinical practice, home warfarin or DOAC therapy is not associated with an increased risk of in‐hospital bleeding compared with no anticoagulant.
Promising Cytotoxicity and Anticancer Activity of Capsicum Annuum

Background: Cancer is the second leading cause of death globally. Most of the anticancer drugs showed poorselectivity. Medicinal plants have proven, historically, their value as a source of molecules with therapeuticpotential. Aim and objective: This study aims to optimize the method of extraction, identification, qualitativeand quantitative analysis of Capsaicin (CAP) from Jordanian Capsicum annuum (C. annuum), and toinvestigate the anticancer activity of the crude extract.Methods: The plants extract from C. annuum wasobtained by Soxhlet extraction, HPLC were used for qualitative and quantitative analysis, and Cytotoxicpotentials was investigated by Cell viability (MTT). Results: Our results showed that Hexan solventrepresented a convenient yield of extraction and the highest percentage of CAP yield with better purity ofextract in comparison with other solvents, Jordan Valley ‘’Al-Ghor’’ showed the highest percentage of CAPyield in extract. Additionally, C. annuum crude extract showed dose depended cytotoxicity activity againsta cancer cell. Conclusion, we have optimized the isolated, qualitative and quantitative analysis of CAP fromthe fruits of C. annuum growing in Jordan in fast and reproducible method.
Inhaled corticosteroids and the risk of lung cancer in COPD: a population-based cohort study

Inhaled corticosteroids (ICSs) are often prescribed in patients with chronic obstructive pulmonary disease (COPD). Their impact on the risk of lung cancer, a leading cause of mortality in COPD patients, remains uncertain. Population-based linked administrative data between the years 1997 and 2007 from the province of British Columbia, Canada, were used to evaluate the association between lung cancer risk and ICS use in COPD patients. COPD was defined on the basis of receipt of three COPD-related prescriptions in subjects ≥50 years of age. Exposure to ICS was incorporated into multivariable Cox regression models using several time-dependent methods (“ever” exposure, cumulative duration of use, cumulative dose, weighted cumulative duration of use and weighted cumulative dose). There were 39 676 patients who met the inclusion criteria. The mean±sd age of the cohort was 70.7±11.1 years and 53% were female. There were 994 (2.5%) cases of lung cancer during follow-up. In the reference case analysis (time-dependent “ever” exposure), ICS exposure was associated with a 30% reduced risk of lung cancer (HR 0.70 (95% CI 0.61–0.80)). ICS exposure was associated with a decrease in the risk of lung cancer diagnosis over all five methods of quantifying exposure. This population-based study suggests that ICS use reduces the risk of lung cancer in COPD patients. Inhaled corticosteroid use appears to reduce the risk of lung cancer in a population-based cohort of COPD patients http://ow.ly/UuDZ30o7Bdi
Sex Differences in Quality of Life in Patients With Atrial Fibrillation: A Systematic Review

Background The goal of this literature review was to assess sex differences in the quality of life (QoL) in patients with atrial fibrillation (AF) and, if possible, to determine if these are due to AF. Methods and Results The electronic database PubMed was searched on January 23, 2018, using the search terms “QoL”, gender differences, “AF” female, and gender to find potential articles that assessed sex differences in QoL in AF patients. In all, 851 articles were identified, from which 25 original studies were eligible for this systematic review. Female AF patients were found to have poorer QoL and more symptoms than male AF patients. They scored lower, predominantly on the physical component score of the Medical Outcomes Study Short‐Form 36 Health Survey. Conclusions The available literature consistently describes poorer QoL in female AF patients but does not clearly address whether this is a reflection of sex differences seen in the general population or is related to AF per se. It is also questionable whether the relatively poorer QoL in women is large enough to be of clinical importance.
Factors Associated with Depression Score in People with Chronic Obstructive Pulmonary Disease at the North Sumatera University Hospital

BACKGROUND: Depression is major global public health problems. This disease is often associated with other chronic diseases, for example, depression in chronic obstructive pulmonary disease (COPD). The presence of depression in chronic disease exacerbates the underlying disease and leads to non-adherence to treatment, loss of disease control, lower quality of life, increased use of health resources, and increased morbidity and mortality and also depression in people with COPD can result in a high economic burden, therefore, screening, investigated the risk factors, and timely treatment of depressive symptoms in people with COPD are very important. AIM: This study aims to determine factors associated with depression score in people with COPD. METHODS: This study is a multivariate type of predictive study with a cross-sectional approach to determine the risk factors of depression score in people with COPD. Symptomatology of depression was assessed using the Beck depression inventory-II. RESULTS: Of the 119 people included, majority 76.5% of the participants were male. The mean ages were 61.09 ± 7.708 years. There was a significant association between depression and independent variables of the duration of illness (p < 0.001), gender (p = 0.006), employment status (p < 0.001), and marital status (p = 0.003) in people with COPD. CONCLUSIONS: Duration of illness, gender, employment status, and marital status were associated with depression in people with COPD. Edited by: Branislav Filipović Citation: Huzaipah H, Effendy E, Nasution NM. Factors Associated with Depression Score in People with Chronic Obstructive Pulmonary Disease at the North Sumatera University Hospital. Open Access Maced J Med Sci. 2021 May 16; 9(T3):168-171. https://doi.org/10.3889/ oamjms.2021. 6298
Genome-wide association study for body weight in cattle populations from Siberia.

Body weight is a complex trait in cattle associated with commonly used commercial breeding measurements related to growth. Although many quantitative trait loci (QTL) for body weight have been identified in cattle so far, searching for genetic determinants in different breeds or environments is promising. Therefore, we carried out a genome-wide association study (GWAS) in two cattle populations from the Russian Federation (Siberian region) using the GGP HD150K array containing 139 376 single nucleotide polymorphism (SNP) markers. Association tests for 107 550 SNPs left after filtering revealed five statistically significant SNPs on BTA5, considering a false discovery rate of less than 0.05. The chromosomal region containing these five SNPs contains the CCND2 gene, which was previously associated with average daily weight gain and body mass index in US beef cattle populations and in humans respectively. Our study is the first GWAS for body weight in beef cattle populations from the Russian Federation. The results provided here suggest that, despite the existence of breed- and species-specific QTL, the genetic architecture of body weight could be evolutionarily conserved in mammals.
OAGB vs BGBP: A retrospective comparative study of a cohort of patients who had bariatric surgery in 2012 at one centre by a single surgeon

Two modifications of Roux‐en‐Y gastric bypass (RYGB), one anastomosis gastric bypass (OAGB) and Roux‐en‐Y banded gastric bypass (BGBP), are gaining popularity in use because the OAGB is reported to be a simpler operation, and the BGBP is reported to have sustained weight loss compared to standard RYGB. A retrospective review and analysis of data comparing outcomes up to 5 years after BGBP and OAGB from a prospectively maintained database of all bariatric metabolic operations in 2012 was performed. Eighty‐two patients underwent a BGBP and 90 an OAGB. The average age and body mass index were 44.12 and 43.97 and 43.57 and 45.79 in the BGBP and OAGB groups, respectively. Postoperative nutrient deficiencies were similar in both groups but were more prominent in the OAGB group. The % excess body weight loss (%EBWL) was 78% and 71.5% at 5 years in the OAGB and BGBP groups, respectively. The % total weight loss (%TWL) was also higher in OAGB compared to the BGBP group, 34.72% and 30.49%, respectively. Resolution of type 2 diabetes (T2DM) was significantly higher in the OAGB group, 79.16%, than in the BGBP group, 71.42%. The resolution of dyslipidaemia and hypertension were similar in both groups, but sleep apnoea resolution was higher in OAGB group. Both operations produced excellent weight loss in the intermediate term. The %EBWL and resolution of T2DM were significantly higher after the OAGB operation at the expense of increased incidence of nutrient deficiencies and hypoproteinemia. Quality of life improvement and patient satisfaction were high after both operations. Long‐term follow up and multicentre prospective studies are needed to confirm these intermediate outcomes.
Biomechanical behavior of maxillary premolars with conservative and traditional endodontic cavities.

OBJECTIVE The objective was to evaluate the effects of the configuration of endodontic cavities with parallel or divergent walls, versus traditional endodontic cavities, on stress distribution, fracture resistance, and fracture mode of maxillary premolars by using both fracture-strength and finite element tests. METHOD AND MATERIALS Thirty-two maxillary first premolars were divided into four groups (n = 8), according to the type of endodontic cavities: without endodontic cavities (control); conservative; conservative with diverging walls; and traditional. After performing root canal treatment and restoration, fracture resistance was evaluated by oblique compressive load. The stress distribution was evaluated by nonlinear finite element analysis by means of micro-computed tomography, operated at 50 kV and 800 mA. The fracture resistance data were analyzed by statistical software. RESULTS Higher stress concentration was observed on the coronal portion of the palatal cusp and the palatal root dentin. Stress concentration on the palatal root dentin was similar for all groups. The stress level on the palatal cusp and at the proximal crests was slightly increased in the traditional endodontic cavities group compared with conservative endodontic cavities. Stress distribution in restored teeth was similar to that of intact teeth. No significant differences were observed in the fracture resistance among different endodontic cavities' design (P = .32). All groups had values similar to those of the control group (P > .05). CONCLUSIONS Regardless of the cavity design, conservative endodontic cavities that preserve marginal ridge integrity did not affect the resistance to fracture, failure mode, or stress distribution in maxillary premolars restored with composite resin. Endodontically treated teeth displayed biomechanical behavior similar to sound teeth.
Methadone's effects on pentylenetetrazole‐induced seizure threshold in mice: NMDA/opioid receptors and nitric oxide signaling

Methadone is a synthetic opioid used to treat opiate withdrawal and addiction. Studies have demonstrated the impact of methadone on seizure susceptibility. This study investigated the modulatory impacts of acute and subchronic (three times daily for 5 days) intraperitoneal methadone treatment on pentylenetetrazole‐induced clonic seizure threshold (CST) in mice, as well as the involvement of the nitric oxide, N‐methyl‐d‐aspartate (NMDA), and µ‐opioid pathways. Acute administration of different doses of methadone (0.1, 0.3, 1, and 3 mg/kg) 45 min before CST significantly decreased the seizure threshold. Additionally, pretreatment with noneffective doses of an opioid receptor antagonist (naltrexone) and NMDA receptor antagonists (ketamine and MK‐801) inhibited methadone's proconvulsive activity in the acute phase, while l‐NAME (a nonspecific nitric oxide synthase (NOS) inhibitor) did not affect that activity. In the subchronic phase, methadone (3 mg/kg) demonstrated an anticonvulsive effect. Although subchronic pretreatment with noneffective doses of l‐NAME and 7‐nitroindazole (a specific neuronal NOS inhibitor) reversed methadone's anticonvulsive activity, aminoguanidine (a specific inducible NOS inhibitor), naltrexone, MK‐801, and ketamine did not change methadone's anticonvulsive characteristic. Our results suggest that NMDA and µ‐opioid receptors may be involved in methadone's proconvulsive activity in the acute phase, while methadone's anticonvulsive activity may be modulated by neuronal NOS in the subchronic phase.