Miracle-dz/UniFAR-FTUs huggingface dataset:
Bell Shape Curves of Hemolysis Induced by Silver Nanoparticles: Review and Experimental Assay

The hemolytic activity assay is a versatile tool for fast primary toxicity studies. This work presents a systematic study of the hemolytic properties of ArgovitTM silver nanoparticles (AgNPs) extensively studied for biomedical applications. The results revealed an unusual and unexpected bell-shaped hemolysis curve for human healthy and diabetic donor erythrocytes. With the decrease of pH from 7.4 and 6.8 to 5.6, the hemolysis profiles for AgNPs and AgNO3 changed dramatically. For AgNPs, the bell shape changed to a step shape with a subsequent sharp increase, and for AgNO3 it changed to a gradual increase. Explanations of these changes based on the aggregation of AgNPs due to the increase of proton concentration were suggested. Hemolysis of diabetic donor erythrocytes was slightly higher than that of healthy donor erythrocytes. The meta-analysis revealed that for only one AgNPs formulation (out of 48), a bell-shaped hemolysis profile was reported, but not discussed. This scarcity of data was explained by the dominant goal of studies consisting in achieving clinically significant hemolysis of 5–10%. Considering that hemolysis profiles may be bell-shaped, it is recommended to avoid extrapolations and to perform measurements in a wide concentration interval in hemolysis assays.
Looking for a virtuous pattern of growth. Some insights for discussion

This paper addresses the current «manufacturing versus services» debate in relation to the question of how to unlock renewed economic growth, taking as point of departure the EC Communication For a European Industrial Renaissance. We present two criteria with which to evaluate the grounds for supporting economic sectors (either manufacturing or services): 1 The capacity to generate employment and 2 The ability to display a positive rate of productivity growth. The highly disaggregated PREDICT database is used in order to evaluate both sectors on these criteria. Our paper concludes that service sectors fulfil both of the above-mentioned criteria, whereas manufacturing sectors do not. The importance of service and manufacturing sub-sectors rooted in ICT and non-ICT R&D-intensive activities is also highlighted.
Media reverberations on the ‘red line’: Syria, metaphor and narrative in news media

This study uses a CADS (Corpus Assisted Discourse Studies) approach to identify a series of axes around which degrees of persuasion can be mapped in debates about international affairs. The author investigates how US and UK news media reported Obama’s use of the term ‘red line’ to describe the potential transgression if Syrian leader Assad used chemical weapons on civilians, which Assad then did. The article examines the connotational, argumentational and rhetorical behaviour of ‘red line’ across news media in the period 4–28 September 2013. In a corpus-assisted analysis of ‘red line’, six discoursal factors emerged as persuasive axes at work: (1) leader’s image; (2) ideological positioning, even in mutual intervention; (3) persuasion consistency; (4) factual investigation; (5) factual interpretation reporting; and (6) evaluated metaphor development. These axes proactively work at the crossroads of metaphor and narrative as transformative and mutually interactive agents in discoursal change. The analysis also identified other subcategories of research potential, plus correlated lexis and concepts such as ‘weakness’ vs ‘strength’. The study’s significance is to ground reflection on the function of metaphor and narrative in steering sense-making in diplomatic practice and to highlight their pragmatic force and dynamics – here in the news genre.
Thinking through making and doing: sport science as an art of inquiry

ABSTRACT How best to summarise the professional work of sport scientists? What if we were to view them as artisans? As enskiled crafts-persons who think through and with their materials? What implications would this idea have for how we take up with research and ensuing scientific methods? Here, we explore these philosophical questions – of applied relevance – through Ingold’s process of making. From this perspective, skilled artisans like potters, basket-makers and sport scientists, think through making and doing, as opposed to make and do through thinking. Where the latter imposes form onto matter by way of conceptualisation, the former goes along with materials in active participation, corresponding with what such things have to say with a skilled attentiveness and selective responsiveness. We argue that the implications of these propositions for research in sport science are profound; encouraging a progression from the traditional hypothetico-deductive theory of scientific method (make and do through thinking), towards an art of inquiry (think through making and doing). In the former, phenomena are studied about, (re)producing categorical (sub-)disciplinary knowledge by way of vertical integration, while in the latter, phenomena are studied with, growing storied knowledge of by way of correspondence. These arguments are not to be construed as a call for more ‘qualitative research’ within the sport sciences, but rather to underline the value of situating participant observation at the core of one’s inquiry. Through a prologue and epilogue, we exemplify our arguments in the very process of this paper’s becoming – detailing the careful attentiveness and selective responsiveness to the various invitations to write, emergent while thinking through making and doing.
Factors Associated with Coping Behaviors of Abused Women: Findings from the 2016 Domestic Violence Survey

Background: Intimate partner violence (IPV) is an important public health problem. In Korea, limited studies have systematically investigated the coping strategies used by female IPV victims. Purpose: We identified the factors associated with abused women’s coping behaviors in South Korea. Methods: This descriptive, cross-sectional study comprises secondary data analysis using the 2016 Domestic Violence Survey; we examined women who experienced domestic violence (DV) in the last year: September to December 2016 (n = 309). Multinomial logistic regression analyses were conducted using an ecological model. Results: Over 50% responded they “did nothing”, while others “escaped the scene of violence or ran outside” and “became reciprocally violent” as coping behaviors sequentially. Compared to the women who “did nothing”, women who experienced feelings of intimidation or fear due to DV, were sexually abused, and suffered physical injury were 5.44, 3.22, and 3.02 times, respectively, more likely to escape from the scene than those who did not. Most showed passive coping behaviors. Relationship level factors, such as type of DV and physical injury, were significantly associated with the type of coping behavior. Conclusions: Our findings emphasize that multi-level comprehensive health programs are required, especially for women coping passively, to prevent and respond to DV.
The influence of wheat straw mulching and straw length on infiltration, runoff and soil loss

Straw mulching is a typical soil and water conservation measure for slope farms, and it plays an important role in preventing soil erosion. The objective of this study was to quantify the effects of the length and coverage of wheat straw on infiltration, runoff and soil loss. In this study, an indoor simulated rainfall experiment was used to study the characteristics of infiltration, runoff and sediment yield under different straw lengths and coverage when the rainfall intensity was 90 mm h−1. The results show that the straw mulch contributes more to the effect of infiltration, runoff and sediment yield than straw length. Increasing the straw coverage increases the average infiltration rate and reduces the cumulative runoff and sediment yield. An increase in straw length, however, reduces the average infiltration rate of the slope and increases the cumulative runoff and sediment yield. The benefits of straw mulch in increasing average infiltration and reducing runoff and sediment yield are consistent with the law of diminishing marginal returns. The marginal benefit of straw is optimal when the straw cover is 3.5 t·hm−2. The sum of straw mulch and length multiplied by cover divided by length has a power function relationship with slope infiltration, while runoff and sediment yield have a power function relationship with its reciprocal. The average infiltration rate of the slope surface is significantly linearly related to the cumulative sediment yield. The simulation accuracy of the Horton model is higher than that of the Kostiakov model. In this study, when the straw length was 3–5 cm and the mulch rate was 4.5 t·hm−2, the average slope infiltration was highest, and the runoff and sediment yield were lowest. Wheat straw surface mulch, when applied as an effective measure for controlling soil erosion and maintaining soil and water resources on sloped fields, can effectively increase infiltration and reduce runoff and sediment yield; wheat mulch is thus critical for the sustainable development of agriculture and ecology on sloping land.
Scepticisms and beyond? A comprehensive portrait of climate change communication by the far right in the European Parliament

ABSTRACT Amid the existing scientific consensus regarding anthropogenic climate change (ACC), research on political ideologies and climate change indicates varying degrees of scepticism amongst conservatives and, especially, the far right, the latter ranging from the anti-liberal radical right to the anti-democratic extreme right. We contribute to this emerging literature by drawing a comprehensive portrait of far-right articulations of climate change to date through an analysis of contributions to plenary debates and explanations of vote delivered by far-right Members of the European Parliament (parliamentary terms 6–8, 2004–19). We illustrate the need for a differentiated understanding of far-right climate-change communication, as most arguments are sceptical not towards the existence of ACC, but the ways in which it is addressed. Furthermore, our analysis indicates that extreme-right actors are slightly more ‘climate-friendly’ than radical-right ones. Therefore, this article contributes to our knowledge of and analytical framework for examining far-right climate-change communication.
Effect of natural fish tail palm fiber on the workability and mechanical properties of fiber reinforced concrete

To improve the pre-cracking behavior and post peak strength of concrete composites, a new variety of natural fiber called Fish Tail Palm Fibers was used as micro reinforcement in concrete. Fish Tail Palm Fibers (FTPF) are completely renewable natural resources and are available in abundance, in many parts of the country including India. Three different volume fractions, (0.1%, 0.2% and 0.3%, and three different lengths of fibers (10 mm, 20 mm and 30 mm) were chosen as the parameters for investigation. Silane treated FTPF was added to concrete and the fresh and mechanical properties were studied. The slump values were slightly affected by the increase in volume fraction of fibers, as the viscosity of concrete increases with fiber content. The compressive strength of the control specimen was 30 MPa (M30). The maximum compressive strength, splitting tensile strength, and flexural strength of Fish Tail Palm Fiber Reinforced Concrete (FTPFRC) specimens are 36 MPa, 2.82 MPa and 4.2 MPa respectively, which were recorded for specimens with 0.2 Volume Fraction (VF) and 30 mm Fiber Length (FL). The increase in the compressive strength, splitting tensile strength and flexure strength is about 20 %, 22% and 30 % with the addition of 0.2 VF of fibers. The findings indicate that the incorporation of fish tail palm fibers reduced the work-ability of concrete. But the mechanical characteristics such as compressive strength, splitting tensile strength, flexural strength, and impact resistance were enhanced with the increase in fiber content and fiber length.
Prediction of Pulmonary Function Parameters Based on a Combination Algorithm

Objective: Pulmonary function parameters play a pivotal role in the assessment of respiratory diseases. However, the accuracy of the existing methods for the prediction of pulmonary function parameters is low. This study proposes a combination algorithm to improve the accuracy of pulmonary function parameter prediction. Methods: We first established a system to collect volumetric capnography and then processed the data with a combination algorithm to predict pulmonary function parameters. The algorithm consists of three main parts: a medical feature regression structure consisting of support vector machines (SVM) and extreme gradient boosting (XGBoost) algorithms, a sequence feature regression structure consisting of one-dimensional convolutional neural network (1D-CNN), and an error correction structure using improved K-nearest neighbor (KNN) algorithm. Results: The root mean square error (RMSE) of the pulmonary function parameters predicted by the combination algorithm was less than 0.39L and the R2 was found to be greater than 0.85 through a ten-fold cross-validation experiment. Conclusion: Compared with the existing methods for predicting pulmonary function parameters, the present algorithm can achieve a higher accuracy rate. At the same time, this algorithm uses specific processing structures for different features, and the interpretability of the algorithm is ensured while mining the feature depth information.
Promoting COVID-19 Vaccination Using the Health Belief Model: Does Information Acquisition from Divergent Sources Make a Difference?

As a promising approach to stop the escalation of the pandemic, COVID-19 vaccine promotion is becoming a challenging task for authorities worldwide. The purpose of this study was to identify the effective sources for disseminating information on the COVID-19 vaccine to promote individuals’ behavioral intention to take the vaccine. Based on the Health Belief Model (HBM), this study illustrated the mechanism of how COVID-19 information acquisition from different sources was transformed into vaccination intentions via health beliefs. Using an online survey in China, the structural equation model results revealed that perceived benefits and cues to action were positively associated with COVID-19 vaccination intentions, and perceived barriers were negatively related to the intentions. However, perceived susceptibility and perceived severity had no significant relationships with the intentions. Moreover, the findings unveiled differences in the effects of acquiring information via multiple sources among traditional media, new media, and interpersonal interactions. Notably, new media and interpersonal interactions were more salient in promoting vaccination intention via health beliefs, compared with traditional media. The findings from this study will benefit health officials in terms of utilizing different information sources in vaccine programs.
Effect of Metformin on T2D-Induced MAM Ca2+ Uncoupling and Contractile Dysfunction in an Early Mouse Model of Diabetic HFpEF

Diabetic cardiomyopathy (DCM) is a leading complication in type 2 diabetes patients. Recently, we have shown that the reticulum-mitochondria Ca2+ uncoupling is an early and reversible trigger of the cardiac dysfunction in a diet-induced mouse model of DCM. Metformin is a first-line antidiabetic drug with recognized cardioprotective effect in myocardial infarction. Whether metformin could prevent the progression of DCM remains not well understood. We therefore investigated the effect of a chronic 6-week metformin treatment on the reticulum-mitochondria Ca2+ coupling and the cardiac function in our high-fat high-sucrose diet (HFHSD) mouse model of DCM. Although metformin rescued the glycemic regulation in the HFHSD mice, it did not preserve the reticulum-mitochondria Ca2+ coupling either structurally or functionally. Metformin also did not prevent the progression towards cardiac dysfunction, i.e., cardiac hypertrophy and strain dysfunction. In summary, despite its cardioprotective role, metformin is not sufficient to delay the progression to early DCM.
Using Sex-Linked Markers via Genotyping-by-Sequencing to Identify XX/XY Sex Chromosomes in the Spiny Frog (Quasipaa boulengeri)

We used genotyping-by-sequencing (GBS) to identify sex-linked markers in 43 wild-collected spiny frog (Quasipaa boulengeri) adults from a single site. We identified a total of 1049 putatively sex-linked GBS-tags, 98% of which indicated an XX/XY system, and finally confirmed 574 XY-type sex-linked loci. The sex specificity of five markers was further validated by PCR amplification using a large number of additional individuals from 26 populations of this species. A total of 27 sex linkage markers matched with the Dmrt1 gene, showing a conserved role in sex determination and differentiation in different organisms from flies and nematodes to mammals. Chromosome 1, which harbors Dmrt1, was considered as the most likely candidate sex chromosome in anurans. Five sex-linked SNP makers indicated sex reversals, which are sparsely present in wild amphibian populations, in three out of the one-hundred and thirty-three explored individuals. The variety of sex-linked markers identified could be used in population genetics analyses requiring information on individual sex or in investigations aimed at drawing inferences about sex determination and sex chromosome evolution.
Kimyrsa, An Oritavancin-Containing Product: Clinical Study and Review of Properties

Abstract Background There is a need for improved antibiotic formulations for the treatment of acute bacterial skin and soft structure infection (ABSSSI), especially with the rise of antimicrobial resistance among Gram-positive bacteria. A new formulation of oritavancin was developed to reduce intravenous infusion volume (from 1000 mL to 250 mL), shorten infusion time (from 3 hours to 1 hour), and provide pharmacies with flexibility in oritavancin preparation (from 5% dextrose in sterile water to either normal saline or 5% dextrose in sterile water) compared with the current formulation. Methods A total of 102 adult patients with a diagnosis of ABSSSI suspected or confirmed to be caused by a Gram-positive pathogen were randomized 1:1 to receive either the new formulation of oritavancin or the current formulation. After a single 1200-mg intravenous infusion of oritavancin, the relative area-under-the-curve exposure of the new formulation and current formulation groups were compared. Safety and tolerability of the new formulation were assessed for treatment-emergent adverse events, serious adverse events, and changes to laboratory parameters. Results The area under the curve for 0 hour to 72 hours postdose was very similar in the new formulation group compared with the current formulation group. No differences in treatment-emergent adverse events were observed between the current and new formulation groups, and all treatment-emergent adverse events were consistent with the known safety profile of the current formulation. Conclusions The new formulation of oritavancin with reduced volume and duration of intravenous infusion demonstrates a safety profile and pharmacokinetics similar to that of the original formulation.
What prognostic information does flow cytometry provide in canine B-cell lymphoma?

PICO question In dogs with B-cell lymphoma, does the use of flow cytometry provide useful prognostic information? Clinical bottom line Category of research question Prognosis The number and type of study designs reviewed Twelve papers were critically reviewed. All were cohort studies Strength of evidence Moderate Outcomes reported There are multiple potential prognostic indicators in canine B-cell lymphoma that flow cytometry can be used to evaluate, including lymphoma stage, survival time and time to progression. There is promising evidence for the use of percentage expression of CD25 and Ki67 cellular markers in providing prognostic information in canine B-cell lymphoma and these should be assessed further in clinical practice. Flow cytometry has also been shown to be useful in assessing bone marrow infiltration and providing prognostic information relating to this. There is also evidence for the prognostic value of measuring expression of class II MHC and CTLA-4 cellular markers, peripheral lymphocyte / monocyte ratio, nodal regulatory T-cell populations and the ratio between T and B lymphocytes in extranodal locations. Peripheral regulatory T-cell populations and cellular size were also assessed, however further investigations are required before confirming their prognostic value Conclusion Flow cytometric analysis offers useful measures of prognosis in canine B-cell lymphoma, although further validation is required before introducing their routine use. Percentage expression of CD25 and Ki67 cellular markers from lymph node aspirates of dogs with B-cell lymphoma appear to be promising prognostic indicators in clinical investigations, however this needs to be translated into clinical practice. While there is evidence for the prognostic value of bone marrow infiltration measured flow cytometrically, expression of class II MHC and CTLA-4, peripheral lymphocyte / monocyte ratio, nodal regulatory T-cell populations and the ratio between T and B lymphocytes in extranodal locations, these need to be further investigated before introducing into clinical practice. As new antibodies against cellular targets in dogs become available, it is likely that flow cytometry will become even more useful in providing prognostic information How to apply this evidence in practice The application of evidence into practice should take into account multiple factors, not limited to: individual clinical expertise, patient’s circumstances and owners’ values, country, location or clinic where you work, the individual case in front of you, the availability of therapies and resources. Knowledge Summaries are a resource to help reinforce or inform decision making. They do not override the responsibility or judgement of the practitioner to do what is best for the animal in their care.
Utility of Circulating Cell-Free DNA in Assessing Microsatellite Instability and Loss of Heterozygosity in Breast Cancer Using Human Identification Approach

The diagnostic and prognostic utility of circulating cell-free DNA (cfDNA) in breast cancer (BC) patients was recently reported. Here, we investigated the use of cfDNA to examine microsatellite instability (MSI) and loss of heterozygosity (LOH) for early BC diagnosis. cfDNA and genomic DNA from 41 female BC patients and 40 healthy controls were quantified using NanoDrop spectrophotometry and real-time PCR. The stability of genomic and cfDNA was assessed using a high-resolution AmpFlSTR MiniFiler human identification kit. Significant increases in cfDNA plasma concentrations were observed in BC patients compared to controls. The genotype distribution of the eight autosomal short tandem repeat (STR) loci D7S820, D13S317, D21S11, D2S1338, D18S51, D16S539, FGA, and CSF1PO were in Hardy–Weinberg equilibrium. Significant differences in the allele frequencies of D7S820 allele-8, D21S11 allele-29, allele-30.2, allele-32.2, and CSF1PO allele-11 were seen between BC patients and controls. LOH and MSI were detected in 36.6% of the cfDNA of patients compared to genomic DNA. This study highlights the utility of plasma-derived cfDNA for earlier, less invasive, and cost-effective cancer diagnosis and molecular stratification. It also highlights the potential value of cfDNA in molecular profiling and biomarkers discovery in precision and forensic medicine.