Miracle-dz/UniFAR-FTUs huggingface dataset:
Classical algorithm for quantum SU(2) Schur sampling

Many quantum algorithms can be represented in a form of a classical circuit positioned between quantum Fourier transformations. Motivated by the search for new quantum algorithms, we turn to circuits where the latter transformation is replaced by the $\textsf{SU}(2)$ quantum Schur Transform -- a global transformation which maps the computational basis to a basis defined by angular momenta. We show that the output distributions of these circuits can be approximately classically sampled in polynomial time if they are sufficiently close to being sparse, thus isolating a regime in which these Quantum $\textsf{SU}(2)$ Schur Circuits could lead to algorithms with exponential computational advantage. Our work is primarily motivated by a conjecture that underpinned the hardness of Permutational Quantum Computing, a restricted quantum computational model that has the above circuit structure in one of its computationally interesting regimes. The conjecture stated that approximating transition amplitudes of Permutational Quantum Computing model to inverse polynomial precision on a classical computer is computationally hard. We disprove the extended version of this conjecture -- even in the case when the hardness of approximation originated from a difficulty of finding the large elements in the output probability distributions. Finally, we present some evidence that output of the above Permutational Quantum Computing circuits could be efficiently approximately sampled from on a classical computer.
Millimeter and submillimeter wave spectra of 13C-glycolaldehydes

Context. Glycolaldehyde (CH 2 OHCHO) is the simplest sugar and an important intermediate in the path toward forming more complex biologically relevant molecules. Astronomical surveys of interstellar molecules, such as those available with the very sensitive ALMA telescope, require preliminary laboratory investigations of the microwave and submillimeter-wave spectra of molecular species includ- ing new isotopologs – to identify these in the interstellar media. Aims. To achieve the detection of the 13 C isotopologs of glycolaldehyde in the interstellar medium, their rotational spectra in the millimeter and submillimeter-wave regions were studied. Methods. The spectra of 13 CH 2 OHCHO and CH 2 OH 13 CHO were recorded in the 150 − 945 GHz spectral range in the laboratory using a solid-state submillimeter-wave spectrometer in Lille. The observed line frequencies were measured with an accuracy of 30 kHz up to 700 GHz and of 50 kHz above 700 GHz. We analyzed the spectra with a standard Watson Hamiltonian. Results. About 10 000 new lines were identiﬁed for each isotopolog. The spectroscopic parameters were determined for the ground- and the three lowest vibrational states up to 945 and 630 GHz. Previous microwave assignments of 13 CH 2 OHCHO were not conﬁrmed. Conclusions. The provided line-lists and sets of molecular parameters meet the needs for a ﬁrst astrophysical search of 13 C-glycolaldehydes.
The Limitations of Optical Spectroscopic Diagnostics in Identifying Active Galactic Nuclei in the Low-mass Regime

Intermediate-mass black holes (IMBHs) with masses between are crucial to our understanding of black hole seed formation and are the prime targets for the Laser Interferometer Space Antenna, yet black holes in this mass range have eluded detection by traditional optical spectroscopic surveys aimed at finding active galactic nuclei (AGNs). In this Letter, we have modeled for the first time the dependence of the optical narrow emission line strengths on the black hole mass of accreting AGN over the range of . We show that as the black hole mass decreases, the hardening of the spectral energy distribution from the accretion disk changes the ionization structure of the nebula. The enhanced high-energy emission from IMBHs results in a more extended partially ionized zone compared with models for higher mass black holes. This effect produces a net decrease in the predicted [O iii]/Hβ and [N ii]/Hα emission line ratios. Based on this model, we demonstrate that the standard optical narrow emission line diagnostics used to identify massive black holes fail when the black hole mass falls below for highly accreting IMBHs and for radiatively inefficient IMBHs with active star formation. Our models call into question the ability of common optical spectroscopic diagnostics to confirm AGN candidates in dwarf galaxies, and indicate that the low-mass black hole occupation fraction inferred from such diagnostics will be severely biased.
Determinants of Regency/City Typology Based on HDI Indicators: Case from West Java, Indonesia

West Java is the most populated province in Indonesia, housing 18% of the total population, and its Gini Ratio shows the prevalence of income inequality. Previous studies have shown a relationship between education and income inequality, partly derived from inequality in education. This study explores the condition of education in regencies/cities in West Java by mapping based on agriculture/non-agriculture classifications, length of the school and life expectancy in 4 quadrants. Significant factors that determine a region in a particular quadrant are explored. Quadrant I is a region of non-agricultural basis, and the average education has graduated junior high. Quadrant III is also a non-agricultural base characterized by elementary school graduates. Quadrant IV is an agricultural base with graduates from elementary school. There is no region in quadrant II, a rural base with junior high graduates. With secondary data from 2017, multinomial logit regression was used for analysis. The result showed life expectancy in quadrants I and III was greater than in IV. Population and gender empowerment index characterize an area in quadrants I and III rather than IV. This is clearer when one looks at the marginal effect where the variable population growth and the development of the gender empowerment index significantly reduce the area's chances of being in quadrant IV. Based on the typology results, we suggest that the government pay more attention to areas in quadrant IV so that educational inequality in West Java can be reduced.
An Optimized Workflow for the Discovery of New Antimicrobial Compounds Targeting Bacterial RNA Polymerase Complex Formation

Bacterial resistance represents a major health problem worldwide and there is an urgent need to develop first-in-class compounds directed against new therapeutic targets. We previously developed a drug-discovery platform to identify new antimicrobials able to disrupt the protein–protein interaction between the β’ subunit and the σ70 initiation factor of bacterial RNA polymerase, which is essential for transcription. As a follow-up to such work, we have improved the discovery strategy to make it less time-consuming and more cost-effective. This involves three sequential assays, easily scalable to a high-throughput format, and a subsequent in-depth characterization only limited to hits that passed the three tests. This optimized workflow, applied to the screening of 5360 small molecules from three synthetic and natural compound libraries, led to the identification of six compounds interfering with the β’–σ70 interaction, and thus was capable of inhibiting promoter-specific RNA transcription and bacterial growth. Upon supplementation with a permeability adjuvant, the two most potent transcription-inhibiting compounds displayed a strong antibacterial activity against Escherichia coli with minimum inhibitory concentration (MIC) values among the lowest (0.87–1.56 μM) thus far reported for β’–σ PPI inhibitors. The newly identified hit compounds share structural feature similarities with those of a pharmacophore model previously developed from known inhibitors.
Diagnosis for Chinese patients with light chain amyloidosis: a scoping review

Abstract Background Amyloid light chain (AL) amyloidosis is the most common systemic amyloidosis. The objective of this scoping review was to map the available literature on the diagnosis of AL amyloidosis in China. Materials and Methods The published academic papers related to the diagnosis of AL amyloidosis were screened from 1 January 2000 to 15 September 2021. Chinese patients who have suspected AL amyloidosis were included. The included studies were categorized into accuracy studies and descriptive studies based on if the studies supplied the diagnostic accuracy data or not. The information on the diagnostic methods reported by included studies was synthesized. Results Forty-three articles were included for the final scoping review, with 31 belonging to descriptive studies and 12 having information on diagnostic accuracy. Although cardiac involvement was second top in Chinese patients with AL amyloidosis, a cardiac biopsy was rare. Next, we found light chain classification and monoclonal (M-) protein identification were essential methods for the diagnosis of AL amyloidosis in China. In addition, some combined tests (e.g. immunohistochemistry and serum free light chain, immunohistochemistry and immunofixation electrophoresis, and serum free light chain and immunofixation electrophoresis) can increase the sensitivity of the diagnosis. Finally, several adjuvant methods (e.g. Imaging, N-terminal-pro hormone BNP, and brain natriuretic peptide test) were important for AL amyloidosis diagnosis. Conclusion This scoping review details the characteristics and results of the recently published studies on diagnosing AL Amyloidosis in China. Biopsy is the most important method for AL Amyloidosis diagnosis in China. In addition, combined tests and some adjuvant methods played essential roles in the diagnosis. Further research is required to determine an acceptable and feasible diagnostic algorithm after symptom onset. REGISTRATION: INPLASY2022100096 KEY MESSAGES This scoping review details the characteristics and results of the recently published studies on diagnosing Amyloid light chain (AL) Amyloidosis in China. Biopsy is the most important method for AL Amyloidosis diagnosis in China. Combined tests and some adjuvant methods played essential roles in the diagnosis.
Benchmark ages for theGaiabenchmark stars

In the era of large-scale surveys of stars in the MilkyWay, stellar ages are crucial for studying the evolution of the Galaxy.But determining ages of field stars is notoriously difficult; therefore, we attempt to determine benchmark ages for the extensively studied Gaia benchmark stars which can be used for validation purposes. By searching the literature for age estimates from different methods and deriving new ages based on Bayesian isochrone fitting, we are able to put reliable limits on the ages of 16 out of the 33 benchmark stars. The giants with well-defined ages are all young, and an expansion of the sample to include older giants with asteroseismic ages would be beneficial. Some of the stars have surface parameters inconsistent with isochrones younger than 16 Gyr. Including a-enhancement in the models when relevant resolves some of these cases, but others clearly highlight discrepancies between the models and observations. We test the impact of atomic diffusion on the age estimates by fitting to the actual surface metallicity of the models instead of the initial value and find that the effect is negligible except for a single turn-off star. Finally, we show that our ability to determine isochrone-based ages for large spectroscopic surveys largely mirrors our ability to determine ages for these benchmark stars, except for stars with log g ≳ 4.4 dex since their location in the Hertzsprung-Russell diagram is almost age insensitive. Hence, isochrone fitting does not constrain their ages given the typical uncertainties of spectroscopic stellar parameters. (Less)
Black holes in vector-tensor theories

We study static and spherically symmetric black hole (BH) solutions in second-order generalized Proca theories with nonminimal vector field derivative couplings to the Ricci scalar, the Einstein tensor, and the double dual Riemann tensor. We find concrete Lagrangians which give rise to exact BH solutions by imposing two conditions of the two identical metric components and the constant norm of the vector field. These exact solutions are described by either Reissner-Nordström (RN), stealth Schwarzschild, or extremal RN solutions with a non-trivial longitudinal mode of the vector field. We then numerically construct BH solutions without imposing these conditions. For cubic and quartic Lagrangians with power-law couplings which encompass vector Galileons as the specific cases, we show the existence of BH solutions with the difference between two non-trivial metric components. The quintic-order power-law couplings do not give rise to non-trivial BH solutions regular throughout the horizon exterior. The sixth-order and intrinsic vector-mode couplings can lead to BH solutions with a secondary hair. For all the solutions, the vector field is regular at least at the future or past horizon. The deviation from General Relativity induced by the Proca hair can be potentially tested by future measurements of gravitational waves in the nonlinear regime of gravity.
Biomedical Investigation of Human Muscle Tissue using Near Infrared Time-Of-Flight spectroscopy

There are many ways to attain information about human muscle tissue, such as X-ray imaging, tissue sampling, magnetic resonance imaging, e.t. c. One of these methods is photon Time-Of-Flight Spectroscopy (pTOFS). This is a non intrusive spectroscopy method which aids in determining the presence of a substance by means of interpreting its spectral signature and scattering property. The spectral signature is determined by the typical wavelengths that are absorbed by the atoms or molecules. Photon Time-Of-Flight Spectroscopy utilizes how light propagates through a highly scattering medium, such as tissue, to obtain information about light absorption (spectral signature) and scattering. This is performed by sending many short light pulses into the medium and recording the time it takes for a single photon to reach the detector for each pulse. The scattering and absorption properties of the medium determines the time of flight for a photon before a detection event, which enables a histogram representing the broadening of a light pulse to be built. The absorption and scattering properties of the medium is then extracted by fitting a computer generated theoretical curve or a computer simulated curve to the recorded data. The study that this bachelor work was based upon refers to measurements on absorption and scattering properties of human muscle tissue for different individuals in the range of 660 to 1340 nm. This to asses if there is any possibility for a trend of these optical properties between different individuals, which could be used for anomaly detection. The results show a promising possibility for this desired trend, but there are uncertainties that make this conclusion difficult to prove. These are for example the small amount of measurements made and the compression of tissue by the used optical fibres.
Photovoltaic effect in multi-domain ferroelectric perovskite oxides

We propose a device model that elucidates the role of domain walls in the photovoltaic effect in multi-domain ferroelectric perovskites. The model accounts for the intricate interplay between ferroelectric polarization, space charges, photo-generation and electronic transport. When applied to bismuth ferrite, results show a significant electric potential step across both 71-degree and 109-degree domain walls, which in turn contributes to the photovoltaic (PV) effect. We also find a strong correlation between polarization and oxygen octahedra tilts, which indicates the nontrivial role of the latter in the PV effect. The domain wall-based PV effect is further shown to be additive in nature, allowing for the possibility of generating above-bandgap voltage
Sequence Properties of an Intramolecular Interaction that Inhibits p53 DNA Binding

An intramolecular interaction between the p53 transactivation and DNA binding domains inhibits DNA binding. To study this autoinhibition, we used a fragment of p53, referred to as ND WT, containing the N-terminal transactivation domains (TAD1 and TAD2), a proline rich region (PRR), and the DNA binding domain (DBD). We mutated acidic, nonpolar, and aromatic amino acids in TAD2 to disrupt the interaction with DBD and measured the effects on DNA binding affinity at different ionic strengths using fluorescence anisotropy. We observed a large increase in DNA binding affinity for the mutants consistent with reduced autoinhibition. The ΔΔG between DBD and ND WT for binding a consensus DNA sequence is −3.0 kcal/mol at physiological ionic strength. ΔΔG increased to −1.03 kcal/mol when acidic residues in TAD2 were changed to alanine (ND DE) and to −1.13 kcal/mol when all the nonpolar residues, including W53/F54, were changed to alanine (ND NP). These results indicate there is some cooperation between acidic, nonpolar, and aromatic residues from TAD2 to inhibit DNA binding. The dependence of DNA binding affinity on ionic strength was used to predict excess counterion release for binding both consensus and scrambled DNA sequences, which was smaller for ND WT and ND NP with consensus DNA and smaller for scrambled DNA overall. Using size exclusion chromatography, we show that the ND mutants have similar Stokes radii to ND WT suggesting the mutants disrupt autoinhibition without changing the global structure.
Evolution of the Stellar Mass–Metallicity Relation. I. Galaxies in the z ∼ 0.4 Cluster Cl0024

We present the stellar mass–stellar metallicity relationship (MZR) in the galaxy cluster Cl0024+1654 at z ∼ 0.4 using full-spectrum stellar population synthesis modeling of individual quiescent galaxies. The lower limit of our stellar mass range is M* = 109.7M⊙, the lowest galaxy mass at which individual stellar metallicity has been measured beyond the local universe. We report a detection of an evolution of the stellar MZR with observed redshift at 0.037 ± 0.007 dex per Gyr, consistent with the predictions from hydrodynamical simulations. Additionally, we find that the evolution of the stellar MZR with observed redshift can be explained by an evolution of the stellar MZR with the formation time of galaxies, i.e., when the single stellar population (SSP)-equivalent ages of galaxies are taken into account. This behavior is consistent with stars forming out of gas that also has an MZR with a normalization that decreases with redshift. Lastly, we find that over the observed mass range, the MZR can be described by a linear function with a shallow slope ( ). The slope suggests that galaxy feedback, in terms of mass-loading factor, might be mass-independent over the observed mass and redshift range.
Political Instability in Latin America: The Cross-Cultural Test of a Causal Model

although at times quite thin, there does appear to be a common thread of agreement running through most of the classic and contemporary literature on theories of revolution—this being the simple proposition that the majority of the participants engaging in such activity are dissatisfied, discontented, and often disaffected individuals. If we can think of “revolution” for the moment in its most general terms—to subsume under such a conceptual label both the simplest manifestation of civil disorder to the most grandiose occurrence of what might be called basic social change—then, it seems, we are in a position to illustrate the emergence of this basic proposition throughout the literature.
Quenching Black Hole Accretion by Active Galactic Nuclei Feedback

Observations of many dim galactic nuclei in the local universe give good estimations of gas density and temperature at the Bondi radius. If we assume the black hole accretes at the Bondi accretion rate and radiates at the efficiency of a low-luminosity hot accretion flow, the predicted nuclei luminosity can be significantly higher than that seen in observations. Therefore, the real black hole mass accretion rate in these sources may be significantly smaller than the Bondi value. Active galactic nucleus feedback may be responsible for decreasing the black hole accretion rate to values much smaller than the Bondi rate. We perform two-dimensional simulations of low-angular-momentum accretion flow at parsec and subparsec scales around low-luminosity active galactic nuclei (LLAGNs). We take into account the radiation and wind feedbacks of the LLAGN. The cross section of particle–particle interaction can be several orders of magnitude larger than that of photon–particle interaction. Therefore, we find that for the LLAGNs, the effects of radiation feedback in decreasing black hole accretion rates are small. However, wind feedback can effectively decrease the black hole mass accretion rate. Due to the decrease of the accretion rate, the black hole luminosity can be decreased by a factor of ∼33–400. These results may be useful for explaining why many galactic nuclei in the local universe are so dim.
Mouse Sertoli Cells Inhibit Humoral-Based Immunity

Transplantation is used to treat many different diseases; however, without the use of immunosuppressants, which can be toxic to the patient, grafted tissue is rejected by the immune system. Humoral immune responses, particularly antibodies and complement, are significant components in rejection. Remarkably, Sertoli cells (SCs), immunoregulatory testicular cells, survive long-term after transplantation without immunosuppression. The objective of this study was to assess SC regulation of these humoral-based immune factors. Mouse SCs survived in vitro human complement (model of robust complement-mediated rejection) and survived in vivo as allografts with little-to-no antibody or complement fragment deposition. Microarray data and ELISA analyses identified at least 14 complement inhibitory proteins expressed by mouse SCs, which inhibit complement at multiple points. Interestingly, a mouse SC line (MSC-1), which was rejected by day 20 post transplantation, also survived in vitro human complement, showed limited deposition of antibodies and complement, and expressed complement inhibitors. Together this suggests that SC inhibition of complement-mediated killing is an important component of SC immune regulation. However, other mechanisms of SC immune modulation are also likely involved in SC graft survival. Identifying the mechanisms that SCs use to achieve extended survival as allografts could be utilized to improve graft survival.
Teachers’ Continuous Intention to Use the Virtual Learning Environment (VLE) Platform: Do Gender Differences Still Matter

: The lacking and obsolete empirical evidence on the manner in which gender inﬂuences VLE adoption indicates the need to conduct new research regarding this matter. Presently, the usage trend of ICT gadgets, equipment, or any sort of technology including VLE has dramatically changed, which perhaps created the possibility of gender effect abolishment, although its existence was previously proven in certain studies conducted in previous decades. Therefore, this study investigates the difference between male and female teachers’ continuous intention to use the VLE platform. The data were gathered from primary and secondary school teachers across the northern region of Malaysia and were analyzed using t -test analysis. The ﬁndings conﬁrmed that there is no difference in terms of gender when it comes to the extent of teachers’ intention to continue using VLE in their pedagogical routines. This implies that increased familiarity with ICT tools has eliminated the gender effect in VLE adoption among teachers.