Miracle-dz/UniFAR-FTUs huggingface dataset:
Errors induced by ozone field horizontal inhomogeneities into simulated nadir‐viewing orbital backscatter UV measurements

Received 15 October 2005; revised 2 August 2006; accepted 25 August 2006; published 4 January 2007. [1] Radiative transfer calculations for nadir-viewing satellites normally assume the atmosphere to be horizontally homogeneous. Yet it has been shown recently that horizontal gradients can lead to significant errors in satellite infrared and microwave soundings. We extend the methodology to nadir backscatter ultraviolet forward modeling and present a first estimate of the effect’s magnitude. The Solar Backscatter Ultraviolet/2 (SBUV/2) instrument, a nadir sounder, serves as our test bed. We find that the RMS error in calculated SBUV radiance induced by ozone inhomogeneities ranges between 0.05 and 0.3% (0.1–0.5%) for the 318 nm (306 and 313 nm) channel. The lower (higher) estimate corresponds to soundings with small (high) solar zenith angle. Occurrence of higher errors, particularly at wavelengths longer than 300 nm, coincides with some of the most interesting atmospheric phenomena like tropopause folds and the south polar ozone hole. This leads to a seasonal variation of the magnitude of the effect. Because of the mostly zonal variability of the ozone distribution, there is also the possibility that biases may be introduced, which is particularly critical if the data are to be assimilated or used to determine trends. The results presented are tested for robustness using different model atmospheres.
Asymmetric activation of microglia in the hippocampus drives anxiodepressive consequences of trigeminal neuralgia

Patients suffering from trigeminal neuralgia (TN) are often accompanied by anxiety and depression. Whether and how microglia are involved in TN-induced anxiodepressive remains unclear. Here, we unconventionally report that TN activates ipsilateral but not contralateral hippocampal microglia, upregulates ipsilateral hippocampal ATP and interleukin1β (IL-1β) levels, impairs ipsilateral hippocampal long-term potentiation (LTP), and induces anxiodepressive-like behaviors in a time-dependent manner in rodents. Specifically, activation of ipsilateral hippocampal microglia is necessary for TN-induced anxiodepressive-like behaviors; and unilateral activating hippocampal microglia is sufficient to elicit an anxiodepressive state and impair LTP. Knockdown of ipsilateral hippocampal P2X7 receptor prevented TN-induced microglial activation and anxiodepressive-like behaviors. Furthermore, we demonstrate that microglia-derived IL-1β mediates microglial activation-induced anxiodepressive-like behaviors and LTP impairment. Together, these findings suggest that priming of microglia with ATP/P2X7R in the ipsilateral hippocampus drives pain-related anxiodepressive-like behaviors via IL-1β. Our results also reveal an asymmetric role of the bilateral hippocampus in TN-induced anxiety and depression.
Interdecadal change of Eurasian snow, surface temperature, and atmospheric circulation in the late 1980s

Boreal winter and spring snow cover extent and snow water equivalent over Eurasia experienced an obvious decrease in late 1980s. A concurrent surface warming is observed over the North Atlantic and Eurasia. The present study documents the relationship among the interdecadal changes in snow, surface air temperature, and wind and the plausible reason for this change. Analysis shows that the snow decrease contributes to the temperature increase only in some limited regions and that the surface warming is largely related to the change in atmospheric circulation. The effect of atmospheric circulation change on surface warming is manifested in wind‐induced heat advection and cloud‐radiation changes. The wind changes over the North Atlantic and Eurasia feature a wave train with an anomalous anticyclone over Europe and anomalous southerly winds over midlatitude east Europe and Asia. The anomalous southerly winds contribute to surface warming through advection of warmer air from lower latitudes. The anomalous anticyclone contributes to surface warming over Europe through anomalous warm advection by bringing warmer air from ocean and enhanced downward shortwave radiation by suppressing upward motion. The wave pattern appears to be connected to equatorial Atlantic warming. Warmer sea surface temperature (SST) in the equatorial Atlantic Ocean enhances convection and induces a lower level anomalous cyclone to the northwest of the SST warming. The role of equatorial North Atlantic SST increase in the formation of the wave train over Eurasia is supported by numerical experiments with an atmospheric general circulation model.
Periprocedural Complications and Long-Term Outcome After Alcohol Septal Ablation Versus Surgical Myectomy in Hypertrophic Obstructive Cardiomyopathy A Single-Center Experience

OBJECTIVES This study compared alcohol septal ablation (ASA) and surgical myectomy for periprocedural complications and long-term clinical outcome in patients with symptomatic hypertrophic obstructive cardiomyopathy. BACKGROUND Debate remains whether ASA is equally effective and safe compared with myectomy. METHODS All procedures performed between 1981 and 2010 were evaluated for periprocedural complications and long-term clinical outcome. The primary endpoint was all-cause mortality; secondary endpoints consisted of annual cardiac mortality, New York Heart Association functional class, rehospitalization for heart failure, reintervention, cerebrovascular accident, and myocardial infarction. RESULTS A total of 161 patients after ASA and 102 patients after myectomy were compared during a maximal follow-up period of 11 years. The periprocedural (30-day) complication frequency after ASA was lower compared with myectomy (14% vs. 27%, p ¼ 0.006), and median duration of in-hospital stay was shorter (5 days [interquartle range (IQR): 4 to 6 days] vs. 9 days [IQR: 6 to 12 days], p < 0.001). After ASA, provoked gradients were higher compared with myectomy (19 [IQR: 10 to 42] vs. 10 [IQR: 7 to 13], p < 0.001). After multivariate analysis, age (per 5 years) (hazard ratio: 1.34 [95% con ﬁ dence interval: 1.08 to 1.65], p ¼ 0.007) was the only independent predictor for all-cause mortality. Annual cardiac mortality after ASA and myectomy was comparable (0.7% vs. 1.4%, p ¼ 0.15). During follow-up, no signi ﬁ cant differences were found in symptomatic status, rehospitalization for heart failure, reintervention, cerebrovascular accident, or myocardial infarction between both groups.
Air/Water Exchange Dynamics of 13 Volatile Chlorinated C1- and C2-Hydrocarbons and Monocyclic Aromatic Hydrocarbons in the Southern North Sea and the Scheldt Estuary

Whereas a lot of marine research work has been done on heavy metals and semivolatile organic compounds, far less attention has been paid to the fate of volatile organic compounds in this area. This work focuses on 13 volatile organic compounds in marine waters and the marine atmosphere. During six campaigns in September 1994−December 1995, simultaneous air and water sampling was carried out in both the southern North Sea area and the Scheldt Estuary. Mean water concentrations for individual compounds were in the 2.2−72.9 ppt range (n = 38), whereas atmospheric concentrations varied between 2.3 and 854 pptv. Samples from the Scheldt Estuary proved to have elevated concentrations of chlorinated compounds. A number of water and air samples showed enhanced concentrations of C2-substituted monocyclic aromatic hydrocarbons, which could not clearly be linked to anthropogenic activities. Back-trajectory calculations showed that a number of over sea atmospheric samples were affected by atmospheric transport from i.
Net primary productivity of macrophyte communities in the experimental marshes after eleven growing seasons

Direct measurements of macrophyte net primary productivity (NPP) were first made at the experimental wetland basins of the Olentangy River Wetland Research Park (ORWRP) in 1997. This study in 2004 represents the eighth set of such measurements. Prior to 1997 (the fourth growing season), macrophyte harvesting for estimation of biomass was not considered a good option as vegetation was just getting established in the basins.
ROLES OF GAG AND NCp7 IN FACILITATING tRNA Lys3 ANNEALING TO VIRAL RNA IN HIV-1.

In protease-negative HIV-1 (Pr(-)), the amount of tRNA Lys3 annealed by Gag is modestly reduced ( ≈ 25%) compared to that annealed by mature nucleocapsid (NCp7) in protease-positive HIV-1 (Pr(+)). However, the tRNA Lys3 annealed by Gag also has a strongly reduced ability to initiate reverse transcription, and binds less tightly to viral RNA. Both in vivo and in vitro , APOBEC3G (A3G) inhibits tRNA Lys3 annealing facilitated by NCp7, but not by Gag. While transient exposure of Pr(-) viral RNA to NCp7 in vitro returns the quality and quantity of tRNA Lys3 annealing to Pr(+) levels, the presence of A3G both prevents this rescue, and creates a further reduction in tRNA Lys3 annealing. Since A3G inhibition of NCp7-facilitated tRNA Lys3 annealing in vitro requires the presence of A3G during the annealing process, these results suggest that in Pr(+) viruses, NCp7 can displace Gag-annealed tRNA Lys3 , and re-anneal it to viral RNA, the re-annealing step being subject to A3G inhibition. This supports the possibility that the initial annealing of tRNA Lys3 in wild type, Pr(+) virus may be by Gag, not NCp7, perhaps offering the advantage of Gag’s preference for binding to RNA stem loops in the 5´ region of viral RNA near the tRNA Lys3 annealing region.
Evidence of Climate Change Declines with Elevation Based on Temperature and Snow Records from 1930s to 2006 on Mount Washington, New Hampshire, U.S.A

Abstract Mount Washington, New Hampshire, has the longest northeastern U.S. mountain climatological record (1930s to present), both at the summit (1914 m) and at Pinkham Notch (612 m). Pinkham's homogenized daily temperature exhibits annual (mean = +0.07°C/decade, p = 0.07; min = +0.11°C/decade, p = 0.01), winter (min = +0.18°C/decade, p = 0.07), spring (max = +0.13°C/decade, p = 0.10), and summer (min = +0.11°C/decade, p = 0.01) warming trends. Though suggesting annual, winter, and spring warming (0.05 to 0.12°C/decade), mean summit temperature trends were not significant. Pinkham shows no significant change in date of first and last snow; however, the summit does but its period of record is shorter. Onset of continuous snow cover has not changed significantly at either site. Thawing degree days trended earlier at the summit (2.8 days/decade; p = 0.01) and Pinkham Notch (1.6 days/decade, p < 0.01), but end of continuous snow cover trended significantly earlier (1.6 days/decade; p = 0.02) only at Pinkham. Growing degree days showed no significant trends at either location. Pinkham exhibits more climatic change than the summit but less than regional lower elevations. Thermal inversions and high incidence of cloud fog commonly at or above the regional atmospheric boundary layer may explain the summit's resistance to climate warming. Caution is needed when extrapolating climate change trends from other mountains or proximate lower elevation climate data to upper elevations.
Associations between Fungal Species and Water-Damaged Building Materials

ABSTRACT Fungal growth in damp or water-damaged buildings worldwide is an increasing problem, which has adverse effects on both the occupants and the buildings. Air sampling alone in moldy buildings does not reveal the full diversity of fungal species growing on building materials. One aim of this study was to estimate the qualitative and quantitative diversity of fungi growing on damp or water-damaged building materials. Another was to determine if associations exist between the most commonly found fungal species and different types of materials. More than 5,300 surface samples were taken by means of V8 contact plates from materials with visible fungal growth. Fungal identifications and information on building material components were analyzed using multivariate statistic methods to determine associations between fungi and material components. The results confirmed that Penicillium chrysogenum and Aspergillus versicolor are the most common fungal species in water-damaged buildings. The results also showed Chaetomium spp. , Acremonium spp. , and Ulocladium spp. to be very common on damp building materials. Analyses show that associated mycobiotas exist on different building materials. Associations were found between (i) Acremonium spp. , Penicillium chrysogenum, Stachybotrys spp. , Ulocladium spp. , and gypsum and wallpaper, (ii) Arthrinium phaeospermum, Aureobasidium pullulans, Cladosporium herbarum, Trichoderma spp. , yeasts, and different types of wood and plywood, and (iii) Aspergillus fumigatus, Aspergillus melleus, Aspergillus niger, Aspergillus ochraceus, Chaetomium spp. , Mucor racemosus, Mucor spinosus, and concrete and other floor-related materials. These results can be used to develop new and resistant building materials and relevant allergen extracts and to help focus research on relevant mycotoxins, microbial volatile organic compounds (MVOCs), and microparticles released into the indoor environment.
Validation of Parental Reports of Asthma Trajectory , Burden and Risk Using the Pediatric Asthma Control and Communication Instrument

Context—Despite a growing interest, few pediatric asthma questionnaires assess multiple dimensions of asthma morbidity, as recommended by national asthma guidelines, or use patientreported outcomes. Objective—To evaluate a questionnaire that measures multiple dimensions of parent-reported asthma morbidity (Direction, Bother and Risk). Patients and Methods—We administered the Pediatric Asthma Control and Communication Instrument (PACCI) and assessed asthma control (PACCI Control), quality of life , and lung function among children presenting for routine asthma care. The PACCI was evaluated for discriminative validity. Results—317 children participated (mean age 8.2 years; 58% male; 44% African American). As parent-reported PACCI Direction changed from “better” to “worse”, we observed poorer asthma © 2013 American Academy of Allergy, Asthma amp; Immunology. All rights reserved. Corresponding Author Sande Okelo, MD, PhD Department of Pediatrics David Geffen School of Medicine at UCLA Mattel Children's Hospital UCLA 10833 Le Conte Ave., MDCC 22-387B Los Angeles, CA 90095 T:310-825-5930 F: 310-7947338 sokelo@mednet.ucla. edu. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. HHS Public Access Author manuscript J Allergy Clin Immunol Pract. Author manuscript; available in PMC 2015 March 17. Published in final edited form as: J Allergy Clin Immunol Pract. 2014 ; 2(2): 186–192. doi:10.1016/j.jaip. 2013.10. 005. A uhor M anscript
Influence of cerebral blood flow on breathing stability

[PDF] [Full Text] [Abstract] , February 1, 2010; 588 (3): 539-549. J. Physiol. Lucas, J. Donnelly, J. D. Cotter and P. N. Ainslie J.-L. Fan, K. R. Burgess, R. Basnyat, K. N. Thomas, K. C. Peebles, S. J. E. Lucas, R. A. I. Influence of high altitude on cerebrovascular and ventilatory responsiveness to CO2 [PDF] [Full Text] [Abstract] , February 1, 2010; 108 (2): 369-377. J Appl Physiol S. Chowdhuri, I. Shanidze, L. Pierchala, D. Belen, J. H. Mateika and M. S. Badr sleep Effect of episodic hypoxia on the susceptibility to hypocapnic central apnea during NREM [PDF] [Full Text] [Abstract] , March 1, 2010; 137 (3): 707-710. Chest Shepherd and P. Ainslie K. R. Burgess, J.-L. Fan, K. Peebles, K. Thomas, S. Lucas, R. Lucas, A. Dawson, M. Swart, K. Exacerbation of Obstructive Sleep Apnea by Oral Indomethacin [PDF] [Full Text] [Abstract] , May 1, 2010; 108 (5): 1433-1439. J Appl Physiol D. K. Mulkey, I. C. Wenker and O. Kreneisz nucleus Current ideas on central chemoreception by neurons and glial cells in the retrotrapezoid [PDF] [Full Text] [Abstract] , June 1, 2010; 298 (6): R1648-R1658. Am J Physiol Regulatory Integrative Comp Physiol and P. N. Ainslie J. L. Fan, K. R. Burgess, K. N. Thomas, K. C. Peebles, S. J. E. Lucas, R. A. I. Lucas, J. D. Cotter breathing stability: the influence of PCO2 gradients Influence of indomethacin on ventilatory and cerebrovascular responsiveness to CO2 and
Modeling framework for sediment deposition, storage, and evacuation in the floodplain of a meandering river: Application to the Clark Fork River, Montana

A theory for the evolution of a river floodplain and the associated movement of tracer sediment is applied to the case of the upper Clark Fork River, Montana, whose floodplain is contaminated with tailings derived from historical mining activities. Deposition of mine tailings raised the elevation of the floodplain, which now contributes contaminated sediment to the channel. The theory is capable of reproducing the basic aspects of the system's evolution, including aggradation of the floodplain during the mining era and subsequent net supply of sediment from floodplain to channel after the cessation of mine input. Results indicate that the natural removal of tailings from the floodplain could take thousands of years, a period longer than is required for the channel to simply rework the tailings. The self‐stabilizing nature of the model results in an evolution toward a new postmine steady state, with tailings eventually almost entirely removed from the system.
Presencia de dinosaurios en la Barranca Los Bonetes en el sur de México (Región de Tiquicheo, Estado de Michoacán) y sus implicaciones cronoestratigráficas

We report the discovery of a new dinosaur locality in the Barranca Los Bonetes (Tiquicheo, southeastern Michoacan state). The material comes from three different levels of a thick continental sedimentary formation. The material is identifi ed to belong to the Hadrosauridae family, and it constitutes the fi rst report of the family in this state. This discovery strongly suggests that the deposits are Late Cretaceous in age, in contrast to Cenozoic age suggested by previous studies.
Sofosbuvir-based treatment of hepatitis C with severe fibrosis (METAVIR F3/F4) after liver transplantation results from the CO23 ANRS CUPILT study

word count: 240 Overall manuscript word count: 3653 Author Contributions: Jérôme Dumortier, Vincent Leroy, Audrey Coilly, Georges-Philippe Pageaux and Jean-Charles DuclosVallée contributed to the conception and design of this study and to the preparation and finalization of the manuscript. Jérôme Dumortier, Vincent Leroy, Christophe Duvoux, Victor de Ledinghen, Claire Francoz, Pauline Houssel-Debry, Sylvie Radenne, Louis d’Alteroche, Valérie Canva, Vincent di Martino, Filomena Conti, Nassim Kamar, Christophe Moreno, Pascal Lebray, Albert Tran, Camille Besch, Armand Abergel, Danielle Botta-Fridlund, Audrey Coilly, Georges-Philippe Pageaux, Jean-Charles Duclos-Vallée and Didier Samuel recruited patients into the study and participated in data collection and data analysis. Claire Fougerou-Leurent, Alpha Diallo, Alexandra Rohel, Emilie Rossignol, contributed to data analysis. All authors critically reviewed the article for important intellectual content and approved the final draft for submission. Page 5 of 31 Liver Transplantation
Electrical structure in thunderstorm convective regions: 2. Isolated storms

Electric field (E) soundings through the convective regions of two types of isolated thunderstorms are examined. Analysis of seven soundings through strong updrafts of isolated supercell storms show that the basic E structure there has three |E| peaks: a positive peak near 8 km height, a negative peak near 10.5 km, and a positive peak near 12 km. Strong updraft soundings are those with average balloon ascent rates in excess of 10 m s -1 . The basic charge structure in strong updrafts of supercells has four charge regions of alternating polarity. The lowermost charge is positive, between about 4 and 8 km, and the uppermost region is negative. All the supercell updraft soundings are incomplete due to balloon burst or lightning-induced instrument destruction below cloud top. Six supercell soundings that ascended outside strong updrafts are used to show that the E and charge structures there are more complex than within the strong updrafts. Analysis of 15 new or previously published soundings through small, New Mexican mountain thunderstorms indicates that the basic E structure in or near their convective cores consists of three |E| peaks: a lower positive peak at about 5 km height, a midlevel negative peak near 6.5 km, and an upper positive peak near 9.5 km. The basic charge structure near the center of New Mexican storm convection has four charge regions, alternating in polarity, with a positive charge region lowest. Soundings in New Mexican convection that did not ascend near the convective cores show more complex E profiles and charge structures.
Stock Price Reaction to News and No-News: Drift and Reversal after Headlines

I examine returns to a subset of stocks after public news about them is released. I compare them to other stocks with similar monthly returns, but no identifiable public news. There is a major difference between return patterns for the two sets. I find evidence of post-news drift, which supports the idea that investors underreact to information. This is strongest after bad news. I also find some evidence of reversal after extreme price movements that are unaccompanied by public news. The patterns are seen even after excluding earnings announcements, controlling for potential risk exposure, and other adjustments. They appear, however, to apply mainly to smaller stocks. I also find evidence that trading frictions, such as short-sale constraints, may play a role in the post-bad-news drift pattern.
University of Southern Denmark Prevalence and risk factors for Enterobacteriaceae in patients hospitalized with community- acquired pneumonia Villafuerte,

Citation for pulished version (APA): Villafuerte, D. , Aliberti, S. , Soni, N. J., Faverio, P., Marcos, P. J., Wunderink, R. G. , Rodriguez, A. , Sibila, O. , Sanz, F. , Martin-Loeches, I. , Menzella, F. , Reyes, L. F. , Jankovic, M. , Spielmanns, M. , Restrepo, M. I. , & GLIMP investigators (2020). Prevalence and risk factors for Enterobacteriaceae in patients hospitalized with communityacquired pneumonia. Respirology, 25(5), 543-551. https://doi.org/10.1111/resp.13663
THROMBOSIS AND HEMOSTASIS von Willebrand factor ﬁ bers promote cancer-associated platelet aggregation in malignant melanoma of mice and humans

and metastasis. Using in vitro settings, mouse models, and human tumor samples, we showed that melanoma cells activate ECs followed by the luminal releaseofVWFfibersandplateletaggregationintumormicrovessels.Analysisofhuman blood samples and tumor tissue revealed that a promoted VWF release combined with alocalinhibitionofproteolyticactivityandproteinexpressionofADAMTS13(adisintegrin-like and metalloproteinase with thrombospondin type I repeats 13) accounts for this procoagulatory milieu. Blocking endothelial cell activation by the low-molecular-weight heparin tinzaparin was accompanied by a lack of VWF networks and inhibited tumor progression in a transgenic mouse model. Ourfindingsimplicateamechanismwhereintumor-derivedvascularendothelialgrowthfactor-A(VEGF-A)promotestumorprogression andangiogenesis.Thus,targetingECactivationenvisionsnewtherapeuticstrategiesattenuatingtumor-relatedangiogenesisand coagulation. ( Blood . 2015;125(20):3153-3163)