Miracle-dz/UniFAR-FTUs huggingface dataset:
Assessment of Anxiety and Stress Levels in Children Undergoing Hemodialysis

Background : Children with chronic kidney disease undergoing hemodialysis therapy experience various physical and mental problems that contribute to psychological disorders such as stress and anxiety. It can affect the mental and physical components of poor quality of life. Several factors seem to trigger anxiety and stress in children on hemodialysis such as co-morbidities, uremia, failure of family support and restrictions in daily life. Aim of the study : was to assess anxiety and stress levels in children undergoing hemodialysis. Design : A descriptive research design was used to achieve the aim of this study. Setting: This study was conducted at Nephrology Unit at Beni-Suef University Hospital affiliated to Ministry of Higher Education and Alhomiat Hospital affiliated to Ministry of Health and population. Sample : A purposive sample of 66 children undergoing hemodialysis were included in the study. Tools : Three tools were used to collect the data. A predesigned questionnaire, Children's Manifest Anxiety Scale (CMAS) and Perceived Stress Scale (PSS). Results : The study findings showed that 66.7% of the studied children were in the age group 11 <15 years with Mean ± SD 9.11 ±1 . 66, as well as 90.9% of the studied children undergoing hemodialysis had sever level of anxiety, and 6.1% of them had moderate level of anxiety, while, 3% of them had mild level of anxiety. The results of the study showed that, 55% of the studied children had sever level of stress, while 42% of them had moderate level of stress, and 2.6% had mild level of stress. Also, there was a positive correlation between children’s total level of anxiety and their total level of stress. Conclusion : It can be concluded that, children undergoing hemodialysis most of them suffering from a sever anxiety, and more than half of them had a high stress level. Meanwhile there was a significant relation between children total level of anxiety and their gender, residence and duration of hemodialysis sessions. Also there was a significant relation between children total level of stress and their gender. Additionally the study concluded that, there was a positive correlation between children’s total level of anxiety and their total level of stress. Recommendations : Application of psychosocial counseling program for children and their families together with social and educational support groups to enable children undergoing hemodialysis to live and function independently in adulthood.
Prevention of Cytokine Release Syndrome in Chimeric Antigen Receptor T-cell Therapy

One of the most powerful forms of cancer immunotherapies is chimeric antigen receptor (CAR) T-cell therapy. Despite being fairly recent in terms of its development and approval, CAR T-cells show great potential as a treatment, since they can efficiently recognize and destroy tumor cells. However, due to the various toxicities associated with this treatment option, CAR T-cell therapy is usually advised as a last resort. The most prominent toxicity of CAR T-cell therapy is the onset of immunotoxicity, which includes Cytokine Release Syndrome (CRS). This review will focus on the recent definition of CRS in general, the mechanisms of CRS progression, how tumor cell pyroptosis via. CAR T-cell therapy can trigger CRS, and the strategies to prevent CRS that have shown efficiency in the application of CAR T-cell patients. By the end, this article will highlight the combination of inhibitors of CRS to improve tumor therapy in the future.
Metamorphic evolution of the Ilomantsi greenstone belt in the Archaean Karelia Province, eastern Finland

Abstract The Ilomantsi greenstone belt is a Neoarchaean, c. 2.75–2.70 Ga volcanic–sedimentary complex in which metamorphic grade increases from staurolite grade in the SW of the belt to sillimanite grade in the NE. In the staurolite zone, prograde garnet zoning indicates pressure and temperature increases from 480–500°C at 2–4 kbar to 560–570°C at 6–7 kbar. Within the sillimanite zone temperatures peaked at 660–670°C at pressures of around 6 kbar. The U–Pb age determinations on monazite from the sillimanite zone yielded both Archaean and Proterozoic ages. One sample contains an exclusively Archaean monazite population of 2620±24 Ma, while another sample has two generations of monazite, with ages of 2664±33 Ma and 1837±13 Ma. The monazite data confirm that the Ilomantsi greenstone belt was metamorphosed simultaneously with the surrounding Neoarchaean migmatite complexes. The apparent clockwise PT path and medium P/T-type metamorphism are consistent with collisional tectonic settings, but the two distinct metamorphic events recorded by monazite indicate that a second, Palaeoproterozoic thermal event caused recrystallization and new mineral growth, in line with previous evidence from other isotopic systems. Accordingly, great care is necessary in defining metamorphic evolutionary P–T–t paths in rocks with complex mineral assemblages, to ensure correct identification of truly coeval mineral assemblages.
Environmental Safety, Stress Levels and Gas Stations' Workers' Knowledge, Attitude and Practices Regarding Occupational Health Hazards

Background: Gas stations have an adverse influence on the environment and workers' health due to the chemicals and physical risks they contain. So, this study aimed to assess environmental safety, stress levels and gas stations' workers' knowledge, attitude and practices regarding occupational health hazards. Subject and Method: Research Design: A descriptive cross-sectional study design. Setting: All gas stations in Assiut City (11stations) that affiliated to Ministry of Petroleum, Egypt Gas Station Directory. Subjects: 140 gas stations' workers. Tools of data collection: Three tools were utilized; Tool (1): A structure interview questionnaire that consisted of five parts; workers' personal data, socio-demographic status assessment scale, knowledge of the occupational health risks associated with gas stations, workers' reported practices and workers' attitude toward occupational health hazards. Tools (2): Assessment of the gas stations' working environment. Tools (3): Assessment of workers' stress levels. Results: It was observed that 54.3% of the workers were from urban area, their mean age ranged from 19.0 to 57.0, 64.3% of them had good knowledge with significant effect with residence, times of work and daily working hours. Also, there was effect of working hours and attainting courses on their reported practices and working times& working hours on workers' stress level. Conclusion: Less than two-thirds of gas stations' workers had high level of knowledge and had positive attitude, more than half of them had unsatisfactory reported practices and approximately two-thirds experienced moderate level of stress. Recommendations: It would be beneficial to establish ongoing training programs for gas stations' workers about occupational health hazards.
Rock record and magnetic response to large earthquakes within Wenchuan Earthquake Fault Scientific Drilling cores

Fault‐related pseudotachylytes are often considered to be produced by large seismic events. To investigate the rock record and magnetic response to large earthquakes within cores from the Wenchuan Earthquake Fault Scientific Drilling borehole 2 (WFSD‐2), we carried out microstructural, geochemical, and rock‐magnetic analyses of representative cores. Based on microstructural observations and powder X‐ray diffraction analyses, we found 21 layers of melt‐origin pseudotachylytes from 579.62 to 599.31 m‐depth in the cores. The presence of early‐formed pseudotachylyte fragments in the new layer suggests that seismic faulting processes exploited the same fault strand more than once. Pseudotachylyte veins have higher values of magnetic susceptibility relative to wall rocks. Rock‐magnetic results indicate that the magnetic minerals within the pseudotachylyte veins are magnetite with varying amounts of paramagnetic minerals. Magnetic hysteresis loops show that a reduction of the grain size of ferromagnetic minerals is not a plausible explanation for the higher magnetic susceptibility values in pseudotachylyte veins. Rock‐magnetic analyses indicate that frictional heating (>500°C) occurred in the pseudotachylyte veins during large earthquakes. The resulting high temperatures induced thermal decomposition of paramagnetic minerals, forming magnetite and contributing to the higher magnetic susceptibility values. Different generations of pseudotachylytes and numerous high magnetic susceptibility zones together demonstrate that ancient powerful earthquakes may have occurred repeatedly in the Longmen Shan thrust belt.
Inhibitory Effect of Propolis Extract on Some Pathogenic Fungi

There is considerable potential for propolis, a complex compound with antibacterial capabilities, to be used as a preservative in dairy manufacturing. This study aimed to study the antifungal effect against four pathogenic fungi including Aspergillus flavus, Aspergillus niger, Penicillium corylophilum and Rhizopus stolinefer . In order to determine antifungal properties, the ethanolic extract of propolis was provided and then added to potato dextrose agar media as 100, 200, 400 and 800 µg/ ml. The study's statistical findings demonstrated that pure propolis extracts work better at boosting concentrations against infections' mycelial development. Additionally, propolis ethanol extracts had an antifungal effect on the fungi that were being examined. Moreover, the tested fungi are very affected by all the tested concentrations. The concentration of 800 µg/ml was the inhibitoriest of three concentrations studied; it showed more than 50% inhibition against all tested fungi.
Effect of Mode of Anesthesia on Fetal Acid-Base Status at Cesarean Section

Background: It is well-known that there's more risk of neonatal respiratory distress with babies born by cesarean delivery than vaginal delivery, regardless of fetal gestational age. Objectives: The aim of this work was to evaluate if different modes of anesthesia affect fetal acid-base for cesarean sections. Patients and methods: This cross-sectional study was conducted on newborns of 150 pregnant women of full-term babies aged 20 to 35 years with no previous maternal medical condition, undergoing elective caesarean section. Patients were allocated into two equal groups; SA group where cesarean sections were done under spinal anesthesia and GA group where cesarean sections were done under general anesthesia. All neonates underwent history taking, and postnatal history including general neonatal examination, Apgar score, neurological examination [Mental status, sensory perception, and reflexes] and systemic examination. Cord blood samples were taken from participant newborns, and immediately after birth and the taken samples were sent for blood gas analysis. Results: There was a significant strong positive correlation between the outcomes and PH, PO 2 , and PCO 2 . Regarding univariate correlations and multivariate correlations, there was a significant strong positive correlation between the outcomes and PH, PO 2 and PCO 2 (P value= <0.0001). Conclusions: It could be concluded that umbilical cord arterial blood gas values, Apgar score (at 1, 5 and 10 min after birth) and neonatal asphyxia are comparable between the two different modes of anesthesia (spinal and general). Moreover, there are significant strong positive correlations between the outcomes and PH, PO 2, and PCO 2 , and they also are strong predictors of the neonatal outcome.
Wearing Facemasks and Maintaining Social Distancing during COIVD-19 among people in the U.S.

This survey of 502 U.S. residents explored how people practiced wearing facemasks and maintaining social distancing during the COVID-19 pandemic. Using Health Benefit Model (HBM), the study found that perceived susceptibility, perceived severity, perceived self-efficacy, perceived benefit, and perceived barrier were significant predictors of wearing facemasks while perceived severity, perceived self-Efficacy, and perceived benefit were significant predictors for maintaining social distancing. While women and people with higher education and higher income were more likely to wear facemasks than others, people of 40 years of age and above and those with higher income tended to maintain social distancing more than others. Participants did not have COVID-19 were more likely to wear facemask and maintain social distancing than those who already had the disease.
Condiciones ambientales de la regeneración del ciprés de la cordillera (Austrocedrus chilensis)* Th e effect of selected environmental conditions on seedling survival in Cypres s of the Cordillera (Austrocedrus chilensis)

SUMMARY This study evaluated the effects of several environmental parameters on seedling survival in Cypress of the Cordi­ llera (Austrocedrus chilensis) both in the greenhouse and in the forest. In the greenhouse studies, seedling survival was evaluated under different irrigation and light regimes In the forest, association of seedlings with vegetation cover was analyzed. Although adult cypress trees are regarded as intolerant to shade, regeneration appeared to require conditions other of light. The intolerance of cypress to shade varied with growth phase, becoming more emphasized in the adult phase. It is concluded that in the greenhouse and in the forest, cypress regeneration takes place mainly under conditions that are protected from desiccation.
Obtenção e caracterização físico-química de farinha e amido de fruta-pão ( Artocarpus

The breadfruit ( Artocarpus altilis ) is a plant native to the islands of the South Pacific and today spread throughout the tropical and subtropical regions of the world. In Brazil, it is considered native because it is vulgarized and acclimatized, becoming wild in many states, mainly in Bahia and Pará. This work aimed to elaborate and characterize the nutritional properties of breadfruit flour for human consumption as a way of using the arena variety. The flour was dried in an oven with air circulation at 60°C for 24 hours. Regarding the physical characterization, the fruits were evaluated in weight and diameter, and the flour was characterized through granulometry. The chemical characterization was carried out through the centesimal and mineral composition of the fresh fruit and flour. The flour had a low Aw evidencing a microbiologically stable product; its composition had 6% moisture, 3.7% protein, 0.7% ash, 2.9% ash, 78.86% starch, and a high yield of 30.51%. The minerals analyzed for both fresh breadfruit and flour were rich in potassium, phosphorus, and magnesium. Thus, breadfruit and its flour prove to be a good energy source for human consumption and a high technological potential due to its high starch content.
Journal of Geophysical Research: Space Physics Properties of current sheet thinning at x∼−10 to −12 RE

We report on Time History of Events and Macroscale Interactions during Substorms (THEMIS) observations of current sheet thinning in Earth’s magnetotail at around x=−10 to −12 Earth radii. The THEMIS spacecraft configuration in October–December 2015 allows us to construct both gradients that contribute to the cross-tail current density jy =μ−1 0 (∂Bx∕∂z − ∂Bz∕∂x) (GSM coordinates). For 17 events when the spacecraft observed a gradual Bz decrease and jy increase, we find the following average scaling relations: for the current density jy ∼ B −7∕4 z , for the lobe magnetic field BL∼ B −1∕4 z , and for the plasma density ni ∼ B −3∕4 z . We show that the temperature of ions and electrons decreases and the plasma pressure gradient ∂p∕∂x rapidly increases during current sheet thinning. The scale Lx =(∂ ln p∕∂x)−1 decreases a few thousand kilometers. We also consider current carriers in thinning current sheets: both ion and electron current-dominated current sheets, preferentially located near dusk and midnight, respectively, are found.
Exercise-Induced Irisin, the Fat Browning Myokine, as a Potential Anticancer Agent

Irisin is a recently discovered myokine that plays an important role in fat metabolism through the browning of white adipose tissue. This myokine is usually secreted after exercise by improving energy balance and has shown great potential as a possible treatment for some metabolic diseases such as obesity, insulin resistance, and inflammation. Obesity has been linked to a higher incidence of some cancers. Furthermore, some studies have shown irisin to have direct positive effects on different types of cancers. Although it is hard to relay conclusions from in vitro to in vivo studies, the majority of the available data favor irisin as a potential substance for cancer regression through reducing proinflammatory markers linked to obesity. However, some controversies remain on the exact benefits of irisin on cancer with some studies showing no or even a negative effect of irisin on cancer. This review summarizes these 2 differing viewpoints and synthesizes them to form a clearer picture of exercise-induced irisin's effects on cancer.
Clinical challenges and strategies on delivery of Oncolytic Virus

Oncolytic Virus therapy, including HSV-1 and adenovirus, is a new type of tumour immunotherapy that uses specific viruses to directly kill tumour cells or to induce the body's intrinsic and acquired immunity to generate anti-tumour immune responses. In addition, Oncolytic Virus is capable of recruiting immune cells to improve the tumour microenvironment, so the development of The clinical significance of oncolytic virus therapy lies in its potential to enhance the efficacy of other immunotherapeutic approaches. However, the delivery of Oncolytic Virus in current clinical trials has huge defects, which greatly limits the benefits of Oncolytic Virus and even produces certain side effects. Therefore, this review discusses the definition and mechanism of Oncolytic Virus and focuses on the defects in Oncolytic Virus delivery, such as systemic delivery and intratumoural delivery. Further, this review also summarizes some improvement strategies against the challenges of intratumoural heterogeneity and vascular complexity.
Recent Progress in Nutrition

Poor dietary habits can lead to obesity and insulin resistance—both of which can impair basal heat shock protein (HSP) expression and the HSP stress response in skeletal muscle. It remains unclear if impairments in HSP expression occur during the early stages of diet-induced obesity and metabolic dysfunction. We determined if basal HSP expression (HSP70, HSP60, HSP25) was impaired in sedentary or exercised rats following the onset of diet-induced obesity. Male Long-Evans rats (N=6-7/group) were assigned to a Western diet (WD) or purified diet (PD). Animals were divided into sedentary (WD and PD) or exercise-trained (WD+Ex and PD+Ex) groups and fed ad libitum for 12-weeks. WD animals displayed higher body mass, fat mass, blood glucose, and HOMA-IR scores compared to PD (p<0.05). Exercise attenuated elevations in HOMA-IR and body mass for WD+Ex (p>0.05) but did not prevent elevations in fat mass or blood glucose when compared to controls. Basal HSP (HSP70, HSP60, HSP25) expression was not impaired in sedentary WD animals when compared to PD (p>0.05) or when WD+Ex was Recent Progress in Nutrition 2021; 1(4), doi:10.21926/rpn.2104001 Page 2/17 compared to PD+Ex (p>0.05). Exercise training elevated HSP70 expression in the gastrocnemius muscle (GAST) (p<0.05), but not in the soleus (SOL) (p>0.05) in WD+Ex and PD+Ex animals. HSP60 and pHSP25 were unaffected by exercise training (GAST and SOL, p>0.05). The onset of diet-induced obesity does not impair skeletal muscle HSP expression in sedentary or exercised animals. Thus, obesity and symptomology of metabolic dysfunction may occur before reductions in skeletal muscle HSP expression.
Cutoff in the Lyman-alpha forest power spectrum Warm IGM or warm dark matter?

We re-analyse high redshift and high resolution Lyman-α forest spectra considered in [1], seeking to constrain the properties of warm dark matter particles. Compared to this previous work, we consider a wider range of thermal histories of the intergalactic medium. We ﬁnd that both warm and cold dark matter models can explain the cut-off observed in the ﬂux power spectra of high-resolution observations equally well. This implies, however, very different thermal histories and underlying reionization models. We discuss how to remove this degeneracy. © 2017 Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). Funded by SCOAP 3 .
Effect of User Satisfaction between Cloud Learning Applications Effect of User Satisfaction between Cloud Learning Applications & University Education Agility & University Education Agility

: University agility has been a critical issue for higher education institutions, little research has focused on university agility and user satisfaction. Drawing on technology acceptance, process, and expectation theories, this paper investigates the mediating role of user satisfaction between cloud learning applications and university education agility. Variance-based structure in the northern region, results show that user satisfaction mediates the link between cloud learning applications and university agility. Implications for practice are discussed
Comparison of pertussis toxin (PT)-neutralizing activities and mouse-protective activities of anti-PT mouse monoclonal antibodies

An assay of neutralizing activity against CHO cell-clustering activity, one of the most common assays for anti-pertussis toxin antibodies, did not correlate well with an assay of the protective activities of monoclonal antibodies. A better correlation between neutralization of leukocytosis-promoting or islet-activating activity and mouse protection against aerosol challenge was seen.
Monoclonal Antibodies: Current Status and Future Innovations in Targeted Therapy

This extensive dissertation offers a detailed examination of monoclonal antibodies (mAbs), their present uses, prospective future developments, and current difficulties. The study investigates the development and mechanism of mAbs, their function in different diseases, and their effectiveness based on clinical trials and case studies. Additionally, it covers potential side effects, negative reactions, and risk reduction techniques. Additionally, it explores the potential advancements, fresh uses, and improvement techniques for mAbs in the future. The effectiveness of mAbs in monotherapy and combination therapy, as well as how the tumor microenvironment and different mAb isotypes can influence this, are also covered in the document. It also explores how mAbs' potential toxicity and side effects may relate to their effectiveness.
Intermittent Fasting and Caloric Restriction as an Adjunctive Treatment in Alzheimer's Disease and Multiple Sclerosis

Alzheimer's disease and multiple sclerosis are neurodegenerative disorders with expensive and complex treatments aimed at reducing the progression of symptoms. However, due to the lack of adequate therapies and the possible adverse effects caused by first-line treatments, it’s necessary to implement better complementary therapeutic approaches that do not produce major side effects and improve symptoms. Caloric restriction and intermittent fasting have been shown to be novel and beneficial strategies in neurodegenerative diseases, through immune, metabolic, and physiological mechanisms. To determine the use of intermittent fasting and caloric restriction as a new treatment in multiple sclerosis and Alzheimer’s disease, a narrative review of original articles in both national and international scientific journals, in English and Spanish languages with no greater obsolescence than five years. The use of caloric restriction and intermittent fasting have generated positive changes, producing a decrease in pro-inflammatory states, oxidative stress, and aging. Approaches that modulate disease progression and improve cognitive function of adenosine monophosphate kinase