Miracle-dz/UniFAR-FTUs huggingface dataset:
Effects of Groove and Steel Fiber on Shear Properties of Concrete with Recycled Coarse Aggregate

In this paper, a series of shear specimens with or without groove were manufactured to mainly analyze the effects of grooves (or shear section height) and steel fibers on the shear properties of concrete with recycled coarse aggregate through double-side direct shear test. In addition, the relationship between the shear strength and the compressive strength and splitting tensile strength of steel fiber reinforced concrete with recycled coarse aggregate (SFRCAC) was also discussed. The experimental results showed that the peak load, deformation corresponding to the peak load and calculated shear strength of the specimens with grooves were lower than those of the specimens without grooves. The steel fiber and recycled coarse aggregate (RCA) had a significant effect on the shear properties of SFRCAC. As the volume content of steel fibers increased, the shear strength of SFRCAC and the corresponding deformation increased gradually. With the replacement ratio of RCA increasing, the shear strength of SFRCAC decreased but the corresponding deformation increased gradually. Finally, the formula for calculating the shear strength of SFRCAC was proposed by analyzing and fitting the test results and the data of related literature.
A new species of Indotyphlus Taylor (Amphibia: Gymnophiona: Caeciliidae) from the Western Ghats, India

A new species of Indian caeciliid caecilian, Indotyphlus maharashtraensis (Amphibia: Gymnophiona), is described based on a series of 12 specimens from the northern Western Ghats of the State of Maharashtra. This species differs from the only other species in the genus, I. battersbyi, in having fewer primary annuli, many more primary annuli bearing secondary annular grooves, and in the presence of a modified subterminal region that has a depressed preanal strip extending anteriorly from around the vent. A key to the species of Indotyphlus is provided.
A Quality Improvement Project Comparing Two Treatments for Deep-Tissue Pressure Injuries to Feet and Lower Legs of Long-term Care Residents.

OBJECTIVE To retrospectively examine clinical outcomes from a feasibility study that compared two treatment options for deep-tissue pressure injuries (DTPIs), including the clinical indicators increasing the risk of deteriorating DTPIs among long-term care residents. METHODS A retrospective chart audit of 40 DTPIs from 33 long-term care residents in two long-term care facilities was conducted to compare (1) polymeric membrane dressings (PMDs) with offloading and (2) a skin barrier film with offloading. RESULTS Of the 13 DTPIs treated with PMDs, only 23% deteriorated to a stage 3 or 4 pressure injury (PI), whereas of the 27 DTPIs treated with skin barrier film, 41% deteriorated to a stage 3 or 4 PI. The clinical factors found to increase the risk of developing and deteriorating DTPIs included weight loss, hypoalbuminemia, debility, dementia, coronary artery disease, and cerebrovascular disease. CONCLUSIONS The PMD group's DTPIs evolved into fewer open PIs despite having higher percentages of clinical indicators for DTPIs. The project findings support the use of PMD dressings for DTPIs; however, more robust research is warranted.
Efficacy of subcutaneous preemptive rituximab in immune‐mediated thrombotic thrombocytopenic purpura: Experience from the first 12 cases

COVID-19 infection, intubation, and death. medRxiv. 2020. https://doi. org/10.1101/2020.04. 08.20058073. [Epub ahead of print]. 4. Martinez DA, Hinson JS, Klein EY, et al. SARS-CoV-2 Positivity rate for Latinos in the Baltimore-Washington, DC Region. JAMA. 2020;324(4): 392-395. https://doi.org/10.1001/jama.2020. 11374. 5. Millett GA, Jones AT, Benkeser D, et al. Assessing differential impacts of COVID-19 on black communities. Ann Epidemiol. 2020;47:37-44. https://doi.org/10.1016/j.annepidem. 2020.05. 003. 6. Garratty G, Glynn SA, McEntire R. ABO and Rh(D) phenotype frequencies of different racial/ethnic groups in the United States. Transfusion. 2004;44(5):703-706. https://doi.org/10.1111/j.15372995. 2004.03338. x. 7. King VM, Armstrong DM, Apps R, Trott JR. Numerical aspects of pontine, lateral reticular, and inferior olivary projections to two paravermal cortical zones of the cat cerebellum. J Comp Neurol. 1998;390(5): 537-551.
Development of Silica-Based Biodegradable Submicrometric Carriers and Investigating Their Characteristics as in Vitro Delivery Vehicles

Nanostructured silica (SiO2)-based materials are attractive carriers for the delivery of bioactive compounds into cells. In this study, we developed hollow submicrometric particles composed of SiO2 capsules that were separately loaded with various bioactive molecules such as dextran, proteins, and nucleic acids. The structural characterization of the reported carriers was conducted using transmission and scanning electron microscopies (TEM/SEM), confocal laser scanning microscopy (CLSM), and dynamic light scattering (DLS). Moreover, the interaction of the developed carriers with cell lines was studied using standard viability, proliferation, and uptake assays. The submicrometric SiO2-based capsules loaded with DNA plasmid encoding green fluorescence proteins (GFP) were used to transfect cell lines. The obtained results were compared with studies made with similar capsules composed of polymers and show that SiO2-based capsules provide better transfection rates on the costs of higher toxicity.
Leukocyte Activation and Antioxidative Defense Are Interrelated and Moderately Modified by n-3 Polyunsaturated Fatty Acid-Enriched Eggs Consumption—Double-Blind Controlled Randomized Clinical Study

This placebo-controlled, double-blind, randomized, interventional study investigated the effects of low/intermediate doses of n-3 polyunsaturated fatty acids (PUFAs) on the endothelial function, markers of leukocyte activation, and oxidative status following dietary intake of n-3 PUFA-enriched hen eggs in young healthy individuals. Twenty young healthy adults of both sexes who consumed n-3 PUFA-enriched hen eggs (two eggs per day, for three weeks, total of approximately 407 mg/day n-3 PUFAs) or regular eggs (two eggs per day for three weeks, total of approximately 75 mg/day n-3 PUFAs) participated in this study. Skin microvascular endothelium-independent and endothelium-dependent vasodilation were assessed by laser Doppler flowmetry. Serum lipid profile and content of free fatty acids, markers of leukocyte activation, biochemical parameters of oxidative stress, as well as antioxidative enzymes serum activity were measured before and after respective dietary protocol. The results of this study revealed significant differences in the markers of leukocyte activation (such as CD11a/LFA-1) and antioxidative defense, which are related to increased intake of n-3 PUFAs, providing the evidence that consumption of nutritionally enriched hen eggs may affect physiological processes related to oxidative balance. The absence of significant changes in microvascular reactivity following supplementation with a low-intermediate dose of n-3 PUFAs, unlike in our previous studies where functional eggs contained ~1 g of n-3 PUFA, suggests the existence of a dose-dependent effect.
Choline Intake as Supplement or as a Component of Eggs Increases Plasma Choline and Reduces Interleukin-6 without Modifying Plasma Cholesterol in Participants with Metabolic Syndrome

Metabolic syndrome (MetS) is characterized by low-grade inflammation and insulin resistance, which increase the risk of heart disease. Eggs have numerous nutrients including choline, carotenoids, and fat-soluble vitamins that may protect against these conditions. Egg phosphatidylcholine (PC) is a major contributor of dietary choline in the American diet. However, uncertainty remains regarding eggs due to their high concentration of cholesterol. In this study, we evaluated the effect of two sources of choline, whole eggs (a source of PC) and a choline supplement (choline bitartrate, CB), on plasma lipids, glucose, insulin resistance, and inflammatory biomarkers. We recruited 23 subjects with MetS to participate in this randomized cross-over intervention. After a 2-week washout, with no choline intake, participants were randomly allocated to consume three eggs/day or CB (~400 mg choline/d for both) for 4 weeks. After a 3-week washout period, they were allocated to the alternate treatment. Dietary records indicated higher concentrations of vitamin E and selenium during the egg period (p < 0.01). Interestingly, there were no changes in plasma total, low density lipoprotein (LDL)- or high density lipoprotein (HDL)-cholesterol, triglycerides, or glucose, compared either to baseline or between treatments. In contrast, interleukin-6 was reduced, with both sources of choline compared to baseline, while eggs also had an effect on lowering C-reactive protein, insulin, and insulin resistance compared to baseline. This study demonstrates that in a MetS population, intake of three eggs per day does not increase plasma LDL cholesterol, and has additional benefits on biomarkers of disease compared to a choline supplement, possibly due to the presence of other antioxidants in eggs.
Sleep deprivation and endothelial function: reconciling seminal evidence with recent perspectives.

Sleep is critical for the maintenance of physiological homeostasis and, as such, inadequate sleep beckons a myriad of pathologies. Sleep deprivation is a growing health concern in contemporary society since short sleep durations are associated with increased cardiovascular disease risk and atherosclerotic plaque development. Vascular endothelial dysfunction is an antecedent to atherosclerosis and cardiovascular disease. Herein, we review seminal literature indicating short sleep durations attenuate endothelial function and explore more recent evidence indicating that sleep deprivation perturbs autonomic balance and the circadian rhythmicity of peripheral vascular clock components. We further examine literature that indicates a mechanistic link between short sleep and endothelial dysfunction and subsequent morbidity. Understanding the mechanisms that regulate endothelial function in the context of sleep deprivation facilitates the development and optimization of interventions, such as exercise, that mitigate the ramifications of inadequate sleep on vascular function and cardiovascular and health.
Determination of Biochemical Composition in Peach (Prunus persica L. Batsch) Accessions Characterized by Different Flesh Color and Textural Typologies

The rising interest in beneficial health properties of polyphenol compounds in fruit initiated this investigation about biochemical composition in peach mesocarp/exocarp. Biochemical evaluation of phenolic compounds and ascorbic acid were quantified through high-performance liquid chromatography (HPLC) in relation to three flesh colors (white, yellow and red) and four flesh typologies (melting, non-melting, slow softening and stony hard) within six commercial cultivars and eight breeding selections of peach/nectarine in 2007. While in 2008, quality and sensorial analyses were conducted on only three commercial cultivars (‘Big Top’, ‘Springcrest’ and ‘Ghiaccio 1’). The red flesh selection demonstrated the highest levels of phenolic compounds (in mesocarp/exocarp) and ascorbic acid. Total phenolic concentration was approximately three-fold higher in the exocarp than the mesocarp across all accessions. Breeding selections generally reported higher levels of phenolics than commercial cultivars. Flesh textural typologies justified firmness differences at harvest, but minimally addressed variations in quality and phenolic compounds. Flesh pigmentation explained variation in the biochemical composition, with the red flesh accession characterized by an abundancy of phenolic compounds and a high potential for elevated antioxidant activity. Sensorial analyses ranked the cultivar with high soluble solids concentration:titratable acidity (SSC:TA) and reduced firmness the highest overall. Red flesh is a highly desirable trait for breeding programs aiming to improve consumption of peaches selected for nutraceutical properties.
Reproductive biology of the blacktip shark, Carcharhinus limbatus (Chondrichthyes: Carcharhinidae) off west and north African coasts

Le requin borde, Carcharhinus limbatus est communement capture le long de la cote occidentale de l'Afrique mais plus rarement en Mediterranee, ou il a ete signale dans le golfe de Gabes (Tunisie meridionale). Subissant des pressions de competition avec les especes sympatriques, le requin gris, C. plumbeus et le requin tisserand, C. brevipinna, il a par consequent migre vers des regions plus septentrionales, dans le golfe de Tunis et au large de la cote algerienne. Les mâles et les femelles sont adultes au-dela de 167 cm et 178 cm de longueur totale (LT), respectivement. Le plus grand mâle et la plus grande femelle avaient respectivement une LT de 216 cm et 245 cm. Il n'y a pas de difference significative concernant les relations taille-masse entre mâles et femelles. C. limbatus est une espece vivipare placentaire. Les femelles adultes ont un seul ovaire et deux uterus fonctionnels dans lesquels les oeufs encapsules et les embryons ne sont pas egalement repartis. L'accouplement a lieu au printemps ou au debut de l'ete, tandis que la parturition se deroule en juillet. La gestation dure approximativement une annee. Le cycle de reproduction est bisannuel, mais chez certains specimens, la vitellogenese se deroule parallelement a la gestation. Le diametre des plus grands ovocytes murs varie de 23 a 25 mm (moyenne: 23,95 ± 0,80) et la masse de 5,9 a 8,4 g (moyenne: 7,48 ± 0,92). Les deux uterus sont divises en chambres et dans chacune d'elles se developpe un unique embryon. La taille et la masse a la naissance, fondees sur les embryons a terme et les plus petits specimens libres, sont comprises entre 61 et 65 cm de LT et 0.935-1.375 kg, respectivement. Une balance chimique de developpement fondee sur les masses seches des plus grands ovocytes murs et des embryons a terme est de 69. C'est la plus grande valeur jamais calculee chez un elasmobranche vivipare et elle confirme que l'espece est matrotrophe. La fecondite ovarienne est legerement plus elevee que la fecondite uterine. Il apparait une faible relation entre les deux categories de fecondite et la LT des femelles. Les portees vont de 6 a 8 individus. Parmi les embryons et les specimens libres, les femelles sont plus nombreuses que les mâles. Ce n'est pas le cas pour les adultes.
Examination of Predation on Early Life Stage Delta Smelt in the San Francisco Estuary Using DNA Diet Analysis

AbstractWe examined predation by nonnative Mississippi Silversides Menidia audens, other small fishes, and invertebrates on the early life stages of the endangered Delta Smelt Hypomesus transpacificus, which is endemic to the Sacramento–San Joaquin Delta in California. Mississippi Silversides and other putative predators were collected primarily via boat electrofishing in the northern reaches of the upper San Francisco Estuary, an area targeted for substantial tidal wetland restoration to enhance habitat for Delta Smelt and other endangered fishes. Predators’ digestive tracts were removed and analyzed for the presence of Delta Smelt DNA by using quantitative PCR TaqMan assays. Across all sites, 69 of 550 Mississippi Silversides tested positive for Delta Smelt DNA. The number of sampled Mississippi Silversides that were positive for Delta Smelt DNA was significantly greater in offshore habitats than in nearshore habitats. Delta Smelt DNA detection data indicated that a wide variety of other species were al.
Improvement of Andean Blueberries Postharvest Preservation Using Carvacrol/Alginate-Edible Coatings

Edible coatings are attractive strategies for blueberries postharvest preservation. In this work, carvacrol/alginate coatings were developed for application on Andean blueberries. Coating formulations were prepared based on blends of sodium alginate (2% w/v), carvacrol (0%, 0.03%, 0.06% or 0.09%), glycerol, and water and applied to the fruits by dip-coating. Then, the fruits were immersed in a calcium batch to induce a crosslink reaction. Changes in the physicochemical and microbiological characteristics of the blueberries were monitored during 21 days of storage at 4 °C. Coated blueberries were better preserved throughout the 21 days of storage because of their lower respiration rate and water loss, in comparison with the uncoated ones. Besides, the coatings enhanced the appearance and the gloss of the fruits. Control fruits showed a significant decrease in the firmness, while, in the coated fruits, this critical postharvest quality was preserved during the entire storage. Coating formulations with 0.09% of carvacrol was the most effective in preventing mesophilic aerobic bacteria and molds/yeasts growth on the fruits during the storage. Edible carvacrol/alginate coatings can be considered as a useful alternative to complement the benefits of refrigerated storage by delaying post-harvest spoilage of Andean blueberries.
Revisiting matrix metalloproteinase 12: its role in pathophysiology of asthma and related pulmonary diseases.

PURPOSE OF REVIEW Matrix metalloproteinases (MMPs) are a family of over 20 zinc-dependent proteases with different biological and pathological activities, and many have been implicated in several diseases. Although nonselective MMP inhibitors are known to induce serious side-effects, targeting individual MMPs may offer a safer therapeutic potential for several diseases. Hence, we provide a concise overview on MMP-12, given its association with pulmonary diseases, including asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis, and other progressive pulmonary fibrosis (PPF), which may also occur in coronavirus disease 2019. RECENT FINDINGS In asthma, COPD, and PPF, increased MMP-12 levels have been associated with inflammation and/or structural changes within the lungs and negatively correlated with functional parameters. Increased pulmonary MMP-12 levels and MMP-12 gene expression have been related to disease severity in asthma and COPD. Targeting MMP-12 showed potential in animal models of pulmonary diseases but human data are still very scarce. SUMMARY Although there may be a potential role of MMP-12 in asthma, COPD and PPF, several pathophysiological aspects await elucidation. Targeting MMP-12 may provide further insights into MMP-12 related mechanisms and how this translates into clinical outcomes; this warrants further research.
Does the Activity in Scapular Muscles During Plyometric Exercises Change When the Kinetic Chain Is Challenged?—An EMG Study

Abstract Werin, MB, Maenhout, AG, Icket, J, Jacxsens, N, Kempkes, E, and Cools, AM. Does the activity in scapular muscles during plyometric exercises change when the kinetic chain is challenged? —An EMG study. J Strength Cond Res 36(7): 1793–1800, 2022—Plyometric exercises for the shoulder are used in rehabilitation and in workout regime when the sport demands high speed power training. The aim of this clinical laboratory electromyography (EMG) study was to determine whether scapular muscle performance differs during plyometric shoulder exercises when changing the demand on the kinetic chain. Thirty healthy overhead athletes, with a mean age of 22.7 years (±2.2), performed 6 exercises, with both a low and a high demand on the kinetic chain, in prone, side and standing in positions. The EMG activity of the upper trapezius (UT), middle trapezius (MT), lower trapezius (LT), and serratus anterior (SA) on the tested side and bilateral of gluteus maximus (GM) and abdominal oblique externus (OE) was registered with wireless surface EMG. Intermuscular muscle ratios UT/SA, UT/MT, and UT/LT were also calculated. The level of significance set for the study was alpha = 0.05. The muscle ratio UT/SA was significantly lower (p < 0.05) when high demand on the kinetic chain compared with low. SA muscle activity showed significantly (<0.001) higher values in the prone position with high demand on the kinetic chain compared with low. All 3 trapezius muscle parts had significantly higher values (p < 0.001) in the prone compared with side and standing positions. The GM and OE showed significantly higher (p ≤ 0.01) activity in positions more demanding for the kinetic chain. When composing a strengthening or a rehabilitation program for athletes, the knowledge of how scapular and trunk muscles interact can be used to amplify the strengthening effect.
Fear of death in the shadow of COVID-19: The mediating role of perceived stress in the relationship between neuroticism and death anxiety

Abstract The present study examined the fear of death among young adults in the wake of the COVID-19. It explored the association between neuroticism and death anxiety during this pandemic crisis, and it also examined the mediating role of perceived stress in this relationship. An online survey of 200 participants, including both students and employed young adults, aged between 18 and 30 years, was conducted. Results showed that neuroticism was positively correlated to death anxiety; however, the relationship was completely mediated by perceived stress. The results and implications are discussed in light of the COVID-19 pandemic.
Proposing Urothelial and Muscle In Vitro Cell Models as a Novel Approach for Assessment of Long-Term Toxicity of Nanoparticles

Many studies evaluated the short-term in vitro toxicity of nanoparticles (NPs); however, long-term effects are still not adequately understood. Here, we investigated the potential toxic effects of biomedical (polyacrylic acid and polyethylenimine coated magnetic NPs) and two industrial (SiO2 and TiO2) NPs following different short-term and long-term exposure protocols on two physiologically different in vitro models that are able to differentiate: L6 rat skeletal muscle cell line and biomimetic normal porcine urothelial (NPU) cells. We show that L6 cells are more sensitive to NP exposure then NPU cells. Transmission electron microscopy revealed an uptake of NPs into L6 cells but not NPU cells. In L6 cells, we obtained a dose-dependent reduction in cell viability and increased reactive oxygen species (ROS) formation after 24 h. Following continuous exposure, more stable TiO2 and polyacrylic acid (PAA) NPs increased levels of nuclear factor Nrf2 mRNA, suggesting an oxidative damage-associated response. Furthermore, internalized magnetic PAA and TiO2 NPs hindered the differentiation of L6 cells. We propose the use of L6 skeletal muscle cells and NPU cells as a novel approach for assessment of the potential long-term toxicity of relevant NPs that are found in the blood and/or can be secreted into the urine.
Connectivity of the Cingulate Sulcus Visual Area (CSv) in Macaque Monkeys

Abstract In humans, the posterior cingulate cortex contains an area sensitive to visual cues to self-motion. This cingulate sulcus visual area (CSv) is structurally and functionally connected with several (multi)sensory and (pre)motor areas recruited during locomotion. In nonhuman primates, electrophysiology has shown that the cingulate cortex is also related to spatial navigation. Recently, functional MRI in macaque monkeys identified a cingulate area with similar visual properties to human CSv. In order to bridge the gap between human and nonhuman primate research, we examined the structural and functional connectivity of putative CSv in three macaque monkeys adopting the same approach as in humans based on diffusion MRI and resting-state functional MRI. The results showed that putative monkey CSv connects with several visuo-vestibular areas (e.g., VIP/FEFsem/VPS/MSTd) as well as somatosensory cortex (e.g., dorsal aspects of areas 3/1/2), all known to process sensory signals that can be triggered by self-motion. Additionally, strong connections are observed with (pre)motor areas located in the dorsal prefrontal cortex (e.g., F3/F2/F1) and within the anterior cingulate cortex (e.g., area 24). This connectivity pattern is strikingly reminiscent of that described for human CSv, suggesting that the sensorimotor control of locomotion relies on similar organizational principles in human and nonhuman primates.