Miracle-dz/UniFAR-FTUs huggingface dataset:
Effective School Boards: Strategies for Improving Board Performance

Introduction: Why School Boards Fail A MODEL FOR BOARD EFFECTIVENESS Making Rational Decisions Functioning Cohesively as a Group Exercising Appropriate Authority Connecting to the Community Working Toward Board Improvement Acting Strategically HOW TO MAKE SCHOOL BOARDS STRONGER Strengthening the Superintendent-Board Partnership Getting the Best Information Engaging in Board Development Conclusion: An Agenda for Action.
Larotrectinib efficacy and safety in adult TRK fusion cancer patients.

3122 Background: A broad range of pediatric and adult malignancies harbor TRK fusions involving the NTRK1, NTRK2, and NTRK3 genes. The highly-selective TRK inhibitor, larotrectinib, has previously shown a high overall response rate (ORR) and a favorable safety profile in patients (pts) with TRK fusion cancer. To better delineate efficacy in adults, as pediatric pts have a particularly high ORR, here we report updated efficacy and safety data from the adult subset of pts with TRK fusion cancer treated with larotrectinib. Methods: Adult pts (aged 18 or older) with TRK fusion cancer detected by local testing in 2 larotrectinib clinical trials (NCT02122913 and NCT02576431) were analyzed. Larotrectinib was administered 100 mg PO BID until disease progression, withdrawal, or unacceptable toxicity. Disease status was assessed by both investigator (INV) and independent assessment (IRC) using RECIST v1.1. Results: As of July 30, 2018, 83 adults (median age: 57 y, range 20–80 y) with TRK fusion cancer had been treated. Cancer types included salivary gland (23%) and thyroid cancer (19%), soft tissue sarcoma (14%), lung cancer (13%), colon cancer and melanoma (7% each), GIST (5%), and bone sarcoma, cholangiocarcinoma, and appendiceal, breast, and pancreas cancer (≤2% each). TRK fusions involved NTRK1 (40%), NTRK2 (2%), and NTRK3 (57%). 77% of pts had received prior systemic therapy (median lines: 2, range 0–10). In 74 pts evaluable per INV, the ORR was 76% with 9% CR, 57% confirmed PR, 9% PR pending confirmation, 12% SD, 11% PD, and 1% not determined; 9 pts were non-evaluable (NE) due to lack of post-baseline assessment. In 65 pts evaluable per IRC, the ORR was 68% with 17% CR, 51% PR, 15% SD, 12% PD, and 5% NE. With a median follow up of 17.2 and 17.5 mo per INV and IRC, respectively, the median duration of response had not been reached (ranges identical: 1.9+ to 38.7+ months). At data cutoff, 63% remained on treatment; 30% had discontinued due to disease progression. Adverse events were mostly grade 1–2. Conclusions: Larotrectinib demonstrated robust tumor-agnostic efficacy and a favorable safety profile in adult pts with TRK fusion cancer. These results support testing for TRK fusion cancer in pts with advanced solid tumors, regardless of site of primary diagnosis. Clinical trial information: NCT02122913 and NCT02576431.
Dynamic planning of distributed generation units in active distribution network

This study proposes long-term dynamic planning of distributed generation (DG) units in distribution networks considering active management (AM). In the AM operation mode, the distribution network equipment is controlled in real time based on the real-time measurements of system parameters (voltage and current). The proposed model determines the optimal size, location and time of investment of DG units. The uncertainty of energy price and rate of load growth is handled using a scenario-based modelling approach. To demonstrate the advantages of dynamic DG planning, its results are compared with those of static model. Also the results of optimal DG planning in active network are compared with those of the passive operation mode. In addition, a technical evaluation and comparison between conventional, passive and active networks have been performed. The proposed model is successfully applied to the 33-bus radial distribution network. The results indicate that using AM, the cost function and losses are decreased effectively compared to the passive management. Computation of the optimal DG planning in AM environment is formulated as a mixed integer non-linear problem which can be solved using commercial optimisation packages like as GAMS.
Multi-objective unit commitment problem with reliability function using fuzzified binary real coded artificial bee colony algorithm

This study proposes a novel methodology that employs fuzzified binary real coded artificial bee colony (ABC) algorithm for solving multi-objective unit commitment problem. On solving unit commitment problem, the proposed binary coded ABC algorithm finds the ON/OFF status of the generating units whereas the economic dispatch is solved using the real coded ABC. Here, three conflicting functions such as fuel cost, emission and reliability level of the system are considered. These functions are formulated as a single objective optimisation problem using the fuzzy set theory. Also, the fuzzy membership design variables are tuned using real coded ABC thereby requirement of expertise for setting these variables are eliminated. The proposed method is validated on six unit system, IEEE 30 bus system, ten unit system, 40 unit system and IEEE RTS 24 bus system. The effectiveness of the proposed technique is demonstrated by comparing its performance with other methods reported in the literature.
Nitrogen Contributions from Peanut Residues to Subsequent Crops

There is not enough evidence to support current peanut N credit recommendations in the Southeast. Nitrogen is released rapidly from peanut residues, and it moves quickly through light-textured soils found in this region. Only a relatively small amount of N from peanut residues is available when subsequent crops need it. This new 5-page document discusses peanut nitrogen credits, nitrogen release from peanut residues, crop performance following peanut, tillage and nitrogen release, and peanut residue distribution and nitrogen release. Written by Arun Jani and Michael J. Mulvaney, and published by the UF/IFAS Agronomy Department, April 2019. http://edis.ifas. ufl.edu/ag431
A traffic flow simulator for network reliability assessment

This paper investigates the transportation network reliability based on the information provided by detectors installed on some links. A traffic flow simulator (TFS) model is formulated for assessing the network reliability (in terms of travel time reliability), in which the variation of perceived travel time error and the fluctuations of origin-destination (OD) demand are explicitly considered. On the basis of prior OD demand and partial updated detector data, the TFS can estimate the link flows for the whole network together with link/path travel times, and their variance and covariance. The travel time reliability by OD pair can also be assessed and the OD matrix can be updated simultaneously. A Monte Carlo based algorithm is developed to solve the TFS model. The application of the proposed TFS model is illustrated by a numerical example.
In Vitro Effect of Estradiol and Progesterone on Ovine Amniotic Epithelial Cells

Amniotic epithelial cells (AECs), an emerging source of extrafoetal stem cells, have recently attracted attention for their great regenerative potential. Since AEC amplifications are accompanied by the loss of their native epithelial phenotype and by the progressive reduction of relevant biological properties, the issue to be addressed is the development of effective culture protocols. In this context, recently, it has been demonstrated that progesterone (P4) supplementation during ovine AEC (oAEC) expansion could prevent the undesirable epithelial-mesenchymal transition (EMT). In contrast, there is no information to date on the role of the other pregnancy steroids in culture. With this aim, the present study has been designed to clarify the impact of estradiol (E2), alone or in combination with P4 (12.5 μM and 25 μM), during oAEC amplification. Steroid supplementations were assessed by testing oAEC proliferation, stemness, EMT, and osteogenic or chondrogenic plasticity. The results indicated that EMT can be prevented exclusively in the presence of high doses of P4, while it occurred rapidly in cells exposed to E2 as denoted by protein (cytokeratin-8 and alpha-SMA) and gene expression (vimentin and snail) profiles. Moreover, steroid exposure was able to influence highly oAEC plasticity. Particularly, P4-treated cells displayed a precommitment towards osteogenic lineage, confirmed by the upregulation of OCN, RUNX2, and the greater deposition of calcium nodules. Conversely, P4 exposure inhibited oAEC chondrogenic differentiation, which was induced in E2-treated cells as confirmed by the upregulation of chondrogenesis-related genes (SOX9, ACAN, and COL2A1) and by the accumulation of Alcian blue-positive extracellular matrix. Simultaneously, E2-treated cells remained unresponsive to osteogenic inductive stimuli. In conclusion, media supplementation with high doses of steroids may be adopted to modulate phenotype and plasticity during oAEC amplification. Relevantly, the osteo or chondro steroid-induced precommitment may open unprecedented cell-based therapies to face the unsolved orthopaedic issues related to osteochondral regeneration.
Development of a Genetic Transformation System of Raspberry Cultivars for Gene Function Analysis

Plants were regenerated from in vitro tissues of red raspberry cultivars ‘Joan J’ and ‘Polana’. The effects of plant growth regulators (PGRs), explant type, and explant age on in vitro shoot and root regeneration were investigated. In vitro leaf and petiole tissues were inoculated in woody plant medium (WPM) supplemented with 200 mg·l polyvinylpyrrolidone (PVP) and various combinations of 6-benzylaminopurine (BA) and/or thidiazuron (TDZ). Results showed that the regeneration rates were 70 % for ‘Joan J’ and 82.2 % for ‘Polana’ when the 7-day-old leaf segments were inoculated on the medium with 2.5 μM BA and 1.0 μM TDZ and WPM with 2.5 μM BA and 0.1 μM TDZ, respectively. Regenerated shoots were rooted both in vitro and ex vitro. The in vitro rooting was first conducted in 1⁄2 Murashige and Skoog (MS) medium with 5 or 10 μM 1-naphthaleneacetic acid (NAA) and 5 or 10 μM indole-3-butyric acid (IBA) for ‘Joan J’. In vitro shoots of ‘Polana’ were pulsed in 1⁄2 MS medium with 10-80 μM NAA or IBA for 7 days, then either kept in the same medium or transferred to auxin-free medium. The result of in vitro rooting showed that 100% and 75% of in vitro shoots of ‘Joan J’ and ‘Polana’ developed roots when they were pulsed with 10 μM and 20 μM NAA, respectively. The ex vitro rooting was conducted by dipping the in vitro shoots in a solution of 0, 500 μM IBA or 500 μM NAA for 10 seconds, then inserting to potting mix (Sunshine mix) for a 4-week rooting and acclimatization period. The ex vitro rooting result showed that an average of 80.9% microcuttings of the two cultivars were rooted with no significant differences in rooting frequency among three treatments.
Acceptance of Internet Banking Systems among Young Managers

The aim of this paper is to determine acceptance of internet banking system among potential young users, specifically future young managers. The relationships and the effects of computer self-efficacy (CSE) and extended technology acceptance model (TAM) on the behavioural intention (BI) to use internet banking system were examined. Measurement of CSE, TAM and BI were adapted from previous studies. However construct for TAM has been extended by adding a new variable which is perceived credibility (PC). A survey through questionnaire was conducted to determine the acceptance level of CSE, TAM and BI. Data were obtained from 275 Technology Management students, who are pursuing their undergraduate studies in a Malaysia's public university. The confirmatory factor analysis performed has identified four variables as determinant factors of internet banking acceptance. The first variable is computer self-efficacy (CSE), and another three variables from TAM constructs which are perceived usefulness (PU), perceived ease of use (PE) and perceived credibility (PC). The finding of this study indicated that CSE has a positive effect on PU and PE of the Internet banking systems. Respondents' CSE was positively affecting their PC of the systems, indicating that the higher the ability of one in computer skills, the higher the security and privacy issues of PC will be concerned. The multiple regression analysis indicated that only two construct of TAM; PU and PC were significantly associated with BI. It was found that the future managers' CSE indirectly affects their BI to use the internet banking systems through PU and PC of TAM. TAM was found to have direct effects on respondents' BI to use the systems. Both CSE and the PU and PC of TAM were good predictors in understanding individual responses to information technology. The role of PE of the original TAM to predict the attitude of users towards the use of information technology systems was surprisingly insignificant.
The Thrift of Avian Influenza in Indonesia

The circulating H5N1 Highly Pathogenic Avian Influenza in chicken has created devastating problems in Indonesia since 2003. Although human cases of Avian Influenza could be exceptionally reduced, however, it remains unsettled in poultry. Phylogenetic analysis of H5N1 virus (2003–2011) revealed the introduction of a single ancestral of 2.1 HA clade before 2003. The enzootic clade subsequently evolved into fourth order with predominantly 2.1. 3.2. Pathological lesions showed cyanotic wattle, torticollis and haemorrhage in chicken feet and multi-internal organs. However, the introduction of vaccination and stringent biosecurity resulted in milder manifestations compared to classical lesions. In 2012, unusual high mortality in duck farms revealed the introduction of exotic clade 2.3.2.1. Despite the inefficient transmission of avian virus to humans and experimental receptor binding of 2.3.2.1 virus that showed avian preference, substitution of N158D and E190D in HA gene indicates possible threat to humans. In the same year, the Government of Indonesia announced the introduction of H9N2. Furthermore, a recent publication (2018) has reported new reassortant between HPAIV H5N1 and LPAIV H3N8 with resulting virulence attenuation in chicken.
Construction of sediment budgets in large scale drainage basins : the case of the upper Indus River

High rates of soil loss and high sediment loads in rivers necessitate monitoring and quantification methodologies so that effective land management strategies can be designed. Construction of a sediment budget can be a useful technique to address these issues since it provides a comprehensive accounting of the fluxes and fate of sediment in the drainage basin. Sediment budget studies in large river basins are usually hampered by inadequate data. Constructing a sediment budget using classical field-based techniques is too labour intensive, time-consuming and expensive for poorly gauged, large river basins. Remote sensing has emerged as a useful tool for studying large basins, and can be combined with GIS tools for identifying potential sediment source areas and quantifying their respective contributions. Such analyses, in combination with historic hydrological records and other auxiliary data, can be utilized for constructing a sediment budget. Following this approach, a framework is developed for constructing sediment budgets for large drainage basins that is prototyped on the upper Indus River basin in northern Pakistan
Isolation, molecular and phylogenetic analysis of porcine encephalomyocarditis virus strain HLJ in China

Background Encephalomyocarditis virus (EMCV) is a positive single-stranded small RNA virus without envelope, which can infect a variety of mammals. Swine are the most susceptible animals, which can cause acute myocarditis and respiratory failure in piglets and reproductive failure in pregnant sows. Diseases caused by EMCV have a wide range of effects on the global swine industry. Methods The tissue grinding fluid of aborted fetus was inoculated on baby hamster kidney 21 (BHK-21) cells to obtain HLJ isolate by cell passage. The virus was identified by reverse transcriptase polymerase chain reaction (RT-PCR), electron microscopic observation and indirect immunofluorescence assay (IFA). HLJ strain was inoculated into mice for animal regression experiment. The whole genome of HLJ strain was amplified and sequenced. The molecular and phylogenetic analysis of its sequence was generated. Results HLJ strain caused the specific cytopathic effect (CPE) on BHK-21 cells and severe pathological changes in mice. Complete genome sequencing and multiple sequence alignment showed that the homology between HLJ strain and other isolates worldwide was 71.5–99.7%. Phylogenetic analysis showed that EMCV isolates fell into five clusters: lineage I, II, III, IV, and V based on the nucleotide sequences of the entire open reading frame (ORF) and VP1 gene. HLJ isolate was grouped into lineage I. Conclusions In this study, a strain of EMCV was isolated from an aborted fetus in Northeast China. The isolation of HLJ strain enriches the epidemiological database of EMCV.
Analysis of the Performance of a Turbocharged S.I. Engine under Transient Operating Conditions by Means of Fast Running Models

The aim of this work is the assessment of the predictive capabilities of fast running models, obtained through an appropriate reduction and simplification process from detailed 1D fluid-dynamic models, for a turbocharged s.i. engine under highly transient operating conditions. Simulations results have been compared with experimental data for different types of models, ranging from fully detailed 1D fluid-dynamic models to map-based models, quantifying the degradation of the model accuracy and the reduction in the computational time for different kinds of driving cycles, from moderately transient such as the NEDC to highly dynamic such as the US06. Although the map based approach was confirmed to be be a viable means to predict fuel economy over the NEDC cycle, even for a downsized and turbocharged engine, thanks to the low accelerations involved and to the almost negligible transients effects, it showed significant discrepancies (error higher than 5%) with the experimental data when applied to highly dynamic driving cycles such as the US06. On the other hand, the use of fast running models was demonstrated to be a suitable solution to obtain a satisfactory accuracy in the estimate of the fuel consumption also over highly dynamic driving cycles, with differences between the simulation results and the measured values which were within the repeatability range of the experimental tests. Moreover, the reduced computational effort of the fast running models allowed to reach close to real-time simulation performance.
Optimal design of state - space digital filters by simultaneous minimization of sensitivity and roundoff noise

The relation between a newly defined sensitivity measure and the noise power gain for scaled filters is given. By means of this relation it is shown that the necessary and sufficient condition to minimize the noise power gain is to minimize the sensitivity measure for unsealed filters. It is shown that the minimization of this sensitivity measure can be carried out without taking into account the dynamic range constraint. A procedure for the simultaneous minimization of the sensitivity measure and the noise power gain is also given.
The Influence of Competence and Work Motivation to Teacher Performance in Smp Negeri At Kota Kupang

The low and poor quality of education in Indonesia is an indicator of the inadequacy performance of educational resources such as teachers in Indonesia. One region that can be studied related to the human resource aspect of education is teachers at Junior High Schools (SMP) in Kupang City, East Nusa Tenggara Province (NTT). The purpose of this research was to determine the effect of competence and work motivation on the performance of teachers in SMP Negeri in Kupang City. This research uses quantitative associative methods from the independent variables (competence or motivation) to the dependent variable (performance). The types of data used are data of primary and secondary. The technique of obtaining data is carried out through interviews, observation, and documentation. The research population was 447 people who were determined by purposive stratified proportional sampling to be 45 respondents. The data analysis used statistical multiple linear regression analysis with the SPSS 20.0 application. The research results showed that partially and simultaneously, the variables of competency (0.332 units) and motivation (0.291 units) had a positive value and had a very significant effect on the performance of the teachers of SMP Negeri in Kupang City. The results of this research can be used as recommendations for school heads, department heads, and policymakers to improve the quality of education output by providing motivation and increasing the competence of teachers. performance.
KINEMATIC AND KINETIC ANALYSIS OF THE ELITE GOLF SWING

The purpose of this study was to determine the association between select biomechanical variables and clubhead speed at impact (CSI) in a sample of elite golfers. Power generation is thought to arise from a number of factors including body rotation and weight shift. CSI is often used to indicate power generation (Fradkin, et al., 2004). We hypothesized that CSI would be highly related to torque, relative hip-shoulder rotation (X-factor) and weight shift during the golf swing.
Mechanical modeling of tissue response during early stage entubulated peripheral nerve regeneration

After severe peripheral nerve injury, such as transection, regeneration has been observed over variable gap lengths with the use of the nerve stump entubulation method. Following entubulation, exudate from transected nerve stumps coagulates into a fibrin matrix within the entubulated space by the end of the first week. Over the following four weeks, two distinct groups of cells migrate into the fibrin-filled gap. The first group consists of fibroblasts which differentiate into the myofibroblast phenotype, forming concentric, force-applying layers collectively known as the contractile capsule around the periphery of newly forming tissue. The second group of cells includes undifferentiated fibroblasts, Schwann cells, and endothelial cells which migrate into the fibrin core preceding axon elongation and synthesis of new nerve tissue. The pressure cuff hypothesis states that the forces applied by myofibroblasts in the contractile capsule deform new tissue and disrupt regeneration. Previous efforts to model the pressure cuff hypothesis have described the release of exudate and the effect of forces applied by cells on the deformation of the regenerate. However, the effects of the conduit chosen for entubulation and the kinetics of early processes have not yet been analyzed. This work aims to further describe the pressure cuff hypothesis, emphasizing activity that occurs within the first two weeks post-transection. A new mechanical model is presented to describe the mechanical attenuation of myofibroblast forces by a nerve conduit, and a novel kinetic model is presented to describe the effects of fibrin clot formation, nerve tissue formation, and contractile capsule formation on the wound healing outcome. The results suggest that the presence of a nerve conduit acts to attenuate the load applied to coagulated fibrin inside the gap during the early stages (< 2 weeks post-injury) of wound healing and that the deformation of fibrin is highly dependent on the growth rate of the capsule and the antagonistic activity between cells that synthesize new nerve tissue and cells that form the contractile capsule. Ex vivo evidence is presented to support the hypothesis that the properties of nerve conduits can affect capsule growth and the migration of Schwann cells and axons into the gap. In the context of the mechanical model, these effects result in altered mechanical states of fibrin that may affect downstream regenerative processes. Additionally, an in vitro model that can be used to further study the effects of biomaterial properties on capsule formation is proposed.