Miracle-dz/UniFAR-FTUs huggingface dataset:
Galcanezumab for the Management of Migraine: A Systematic Review and Meta-Analysis of Randomized Placebo-Controlled Trials

Introduction Migraine is a frequent neurological condition manifested by several episodes of headache. Calcitonin gene-related peptide (CGRP) has been shown to play a key role in the pathophysiology of migraine. Galcanezumab is a monoclonal antibody that binds CGRP and inhibits its action, without affecting the CGRP receptor. The aim of this study is to carry out a systematic review and meta-analysis of all randomized placebo-controlled trials that evaluated the efficacy of galcanezumab (120 mg or 240 mg) for the management of migraine. Methods We screened four databases (PubMed, SCOPUS, Embase, and Cochrane Central) from inception to October 10, 2020. Studies meeting the following criteria were included: (i) Patients: individuals with migraine, (ii) Intervention: galcanezumab at a dose of 120 mg or 240 mg, (iii) Comparator: placebo, (iv) Outcomes: prespecified efficacy and safety outcomes, and (v) Study design: randomized placebo-controlled trials. Efficacy outcomes included change in migraine headache days (MHDs), change in MHDs with acute medication use, patient global impression of severity (PGI-S) score, migraine-specific quality of life role function-restrictive domain (MSQ RF-R) score, and migraine disability assessment (MIDAS) score. Safety outcomes included frequency of injection-site pain, nasopharyngitis, and upper respiratory tract infection (URTI). Moreover, we used the Cochrane Collaboration's risk of bias tool to assess the risk of bias of the included studies. Review Manager Software, version 5.4. 1, was used for statistical analysis. Mean difference and risk ratio with 95% confidence interval were used to analyze continuous and dichotomous outcomes, respectively. We used the fixed-effects and random-effects models to analyze homogeneous and heterogeneous data, respectively. Results A total of six studies comprising 4,023 patients were included in this systematic review and meta-analysis. When compared to placebo, both doses of galcanezumab were highly effective in decreasing MHDs (p<0.001), reducing MHDs with acute medication use (p<0.001), and improving the PGI-S score (p<0.001). On the other hand, MSQ RF-R and MIDAS scores were significantly enhanced only in the 240-mg dose group (p<0.001). With regard to side effects, the rates of injection-site pain and nasopharyngitis did not substantially differ between galcanezumab (inclusive of 120 mg and 240 mg) and placebo groups. Nonetheless, when compared to placebo, galcanezumab 120 mg, but not galcanezumab 240 mg, substantially correlated with a higher rate of URTI. Conclusions Galcanezumab is clinically safe and efficient for the management of migraine, and the use of a higher dose increases its efficacy. Future research directions should be geared toward determining the optimal dose of galcanezumab in the management of patients with migraine. Moreover, head-to-head comparative studies between galcanezumab and other related anti-CGRP receptor monoclonal antibodies are warranted.
Intrinsic magnetic properties of hexagonal LuFeO3 and the effects of nonstoichiometry

We used oxide molecular-beam epitaxy in a composition-spread geometry to deposit hexagonal LuFeO3 (h-LuFeO3) thin films with a monotonic variation in the Lu/Fe cation ratio, creating a mosaic of samples that ranged from iron rich to lutetium rich. We characterized the effects of composition variation with x-ray diffraction, atomic force microscopy, scanning transmission electron microscopy, and superconducting quantum interference device magnetometry. After identifying growth conditions leading to stoichiometric film growth, an additional sample was grown with a rotating sample stage. From this stoichiometric sample, we determined stoichiometric h-LuFeO3 to have a T N = 147 K and M s = 0.018 μ B/Fe.
Chemical analysis and insecticidal activity of Ocimum gratissimum essential oil and its major constituent against Spodoptera frugiperda (Smith, 1797) (Lepidoptera: Noctuidae)

The fall armyworm, Spodoptera frugiperda, causes damage at several stages of the maize crop cycle. Due to its resistance to synthetic insecticides and the high costs of pest control, there is an ever-increasing amount of research on alternative or complementary products that have a minor environmental and financial impact on agriculture. Therefore, the aim of this study was to evaluate the chemical composition and insecticidal potential of Ocimum gratissimum (african basil) leaves essential oil and the effect of its major component, thymol, on S. frugiperda control. Gas Chromatography (GC) and Gas Chromatography-Mass Spectrometry (GC-MS) analysis identified p-cymene, γ-terpinene, and thymol compounds as the main constituents of the oil, which presented a yield of 4.75%. Among the 30 identified compounds, thymol (33.2%) was the major constituent, representing 97.8% of the total oil. The efficacy of both the oil and thymol standard (Sigma-Aldrich) was evaluated against S. frugiperda using topical acute toxicity and contact surface tests at different concentrations. The oil was more active than thymol standard, with topical acute toxicity of LD50 at 0.020 μl/insect and LC50 at 0.171 μl/cm 2 for contact surface toxicity. The oil proved to be superior to the thymol standard, offering an effective and promising alternative for the control of S. frugiperda, which is most likely due to the contribution of other oil components that acted Research, Society and Development, v. 9, n. 11, e4999119787, 2020 (CC BY 4.0) | ISSN 2525-3409 | DOI: http://dx.doi. org/10.33448/rsd-v9i11.9787 3 synergistically. Consequently, this result provides an opportunity for further study and the development of an effective fall armyworm control system.
Bank Capital and Real GDP Growth

We study the relationship between bank capital ratios and the distribution of future real GDP growth. Growth in the aggregate bank capital ratio corresponds to a smaller left tail of GDP—smaller crisis probability—but at the cost of a smaller right tail of growth outcomes—smaller probability of exuberant growth. This trade-off persists at horizons of up to eight quarters, highlighting the long-range consequences of changes in bank capital. We show that the predictive information in bank capital ratio growth is over and above that contained in real credit growth, suggesting importance for bank capital beyond supplying credit to the nonfinancial sector. Our results suggest that coordination between macroprudential and monetary policy is crucial for supporting stable growth.
Soil erosion potential of organic versus conventional farming evaluated by USLE modelling of cropping statistics for agricultural districts in Bavaria

Abstract. Organic agriculture (OA) aims to identify a production regime that causes less environmental problems than conventional agriculture (CA). We examined whether the two systems differ in their susceptibility to soil erosion by water. To account for the large heterogeneity within the rotations practised on different farms, we chose a statistical evaluation which modelled erosion using the USLE method from the cropping statistics for 2056 districts in Bavaria (70 547 km2; 29.8% arable). Physical conditions of erosion were determined in a rectangular grid yielding 13 125 grid‐cells of c. 5 km2 each. For validation, erosion was measured in 10 sub‐watersheds on two neighbouring OA and CA farms over 8 years (287 erosive events). On average, about 15% less erosion on arable land was predicted for OA than for CA due to the larger area of leys, although OA occupies areas that are susceptible to erosion more often than CA. The same conclusions could be drawn from the validation data. These data also demonstrated that erosion could be reduced considerably below 1 t ha−1 yr−1 with best management practices under both farming systems. In contrast, at the countrywide scale, cropping did not change adequately with site conditions favouring erosion. The need for erosion control seems not to influence crop rotation decisions on erosion‐prone sites.
Two-Step IMC−PID Method for Multiloop Control System Design

Proportional−integral−derivative (PID) controller tuning method based on the internal model control is one of the simplest tuning rules and provides excellent performances for various processes. It has one design parameter which determines the speed of closed-loop response. As the design parameter changes, the controller gain changes while integral and derivative times usually remain constant. Hence, the method can be extended easily to the design of multiloop control systems because there are simple methods to find stable multiloop proportional controller gains. However, integral and derivative times independent of the design parameter can cause poor closed-loop responses for some processes such as those with small dead times. For such processes, 2 degree of freedom control systems are usually required, and a two-step method where a proportional controller is designed first and then a PID controller is designed for the compensated system can be used to design the 2 degree of freedom control systems. This.
New Modeling Approaches Based on Varimax Rotation of Functional Principal Components

Functional Principal Component Analysis (FPCA) is an important dimension reduction technique to interpret the main modes of functional data variation in terms of a small set of uncorrelated variables. The principal components can not always be simply interpreted and rotation is one of the main solutions to improve the interpretation. In this paper, two new functional Varimax rotation approaches are introduced. They are based on the equivalence between FPCA of basis expansion of the sample curves and Principal Component Analysis (PCA) of a transformation of the matrix of basis coefficients. The first approach consists of a rotation of the eigenvectors that preserves the orthogonality between the eigenfunctions but the rotated principal component scores are not uncorrelated. The second approach is based on rotation of the loadings of the standardized principal component scores that provides uncorrelated rotated scores but non-orthogonal eigenfunctions. A simulation study and an application with data from the curves of infections by COVID-19 pandemic in Spain are developed to study the performance of these methods by comparing the results with other existing approaches.
Graywater Reuse: The Effects on Income and Agricultural Production Sustainability of Family Farming Systems in the Semiarid Region of Ceará, Brazil

The semi-arid region of Ceara is a Brazilian area that is exposed to long and frequent periods of drought. Water scarcity is a threat to the population’s well-being and agricultural activities. We evaluated the effects of graywater reuse for agriculture on income and sustainability of agricultural production in the municipality of Iguatu, located in the semiarid region of the state of Ceara. It is an important research because it deals with a strategy that aims to reduce farmers’ vulnerability to the lack of water. There are no studies that assess the impacts of water reuse in the region. The propensity score matching technique was applied, and primary data were obtained by interviewing beneficiaries (treated group) and non-beneficiaries (control group). The results showed that the program has effects on sustainable agricultural production of small farmers because of the use of non-aggressive agricultural practices. In the group of beneficiaries, the income is 21.9% higher than of that in the group of non-beneficiaries. In addition, families that adopt water reuse have 26.8% higher levels of sustainability than those that do not adopt this strategy of living with drought.
Western dietary pattern is associated with higher risk of lower lean muscle mass in Korean postmenopausal women: data from the Korea National Health and Nutrition Examination Survey 2008–2011

BACKGROUND/OBJECTIVES In a healthy person, from 35 years of age, there is an annual loss of muscle mass at the rate of 1–2% and is associated with a decline in the quality of life. This study aimed to identify the particular dietary patterns associated with the risk of lower lean muscle mass in Korean postmenopausal women. SUBJECTS/METHODS The Korea National Health and Nutrition Examination Survey (KNHANES) is a population-based, continuous cross-sectional annual survey. The participants of the KNHANES IV (2008–2009) and V (2010–2011) were considered for this study. The study sample consisted of 1548 postmenopausal women, aged 45–86 years. Lower lean muscle mass was defined as having appendicular skeletal muscle mass corrected for body weight less than 1 standard deviation of the young reference group aged 20 to 39 years in KNHANES IV and V. To identify the dietary pattern using factor analysis, 24-h recall data was used. RESULTS The prevalence of lower lean muscle mass was 31.3% in this study population. Four dietary patterns were identified by factor analysis; ‘Diverse’, ‘Western’, ‘Traditional’, and ‘Snacks and beverages’. The ‘Western’ pattern, highest factor loadings for flour and bread, potatoes, red meat, processed meat, eggs, and cheese, was significantly associated with a high (60%) risk of lower lean muscle mass (odds ratio [95% confidence interval] = 1.60 [1.07–2.39], P for trend = 0.01) after adjustments for potential covariates. The other 3 dietary patterns were not associated with lower lean muscle mass. CONCLUSIONS The study findings suggest that the ‘Western’ dietary pattern that includes flour and bread, potatoes, red meat, processed meat, eggs, and cheese, may be associated with a higher risk of lower lean muscle mass in Korean postmenopausal women.
The Role of Ethnic Diversity in Stimulating Innovation Processes: Comparative Analysis of Poland, the Czech Republic and Hungary

Purpose: Since existing literature suggests that ethnic diversity is one of the key elements that shape the dynamics of innovation, we examine whether inventions generated by ethnically diverse teams in the Czech Republic, Poland and Hungary are more valuable than those created by homogenous teams of native researchers. Design/Methodology/Approach: Using the OLS method, we estimate the parameters of the regression model in order to examine the relationship between ethnic diversity and the quality of technical solutions created as well as to determine which ethnic group and which combination of these groups (for each country) has the greatest impact on the quality of inventions. We take the frequency of citation as a measure of the quality of inventions, and the degree of ethnic diversity in the inventor team is measured using the Herfindahl index. Findings: Based on a cross-sectional data set being a sample of 2518 international patent applications (PCT) from 2004-2012, we have observed that both the mere presence of foreigners as well as greater ethnic diversity in the inventor team significantly increase the quality of technical solutions in Poland and Hungary, and moderately in the Czech Republic. Our study has also revealed that of all ethnic groups, Americans have the greatest impact on the citation of inventions, and it is the case in all three countries covered by the study. The optimal combination of individual groups, however, is different for each of these three countries: in Poland, the highest quality of inventions is related to the presence of citizens of the US, Belgium, Japan and Turkey, in Hungary – the US and Israel, and in the Czech Republic – the US, Germany and Canada. Practical Implications: The research results can be used by decision makers in Poland, the Czech Republic and Hungary when shaping the countries’ migration and innovation policies. Originality/Value: Original research.
Efficiency of a System for the Separate Collection of the Biowaste from Municipal Solid Waste. A Spanish Pilot Case Study

Background:According to EU regulations, member states shall take measures to encourage the recycling of biowaste in a way that fulfils a high level of environmental protection. In Spain, the separate collection of biowaste is only implemented in some regions. For this reason, a pilot scheme based on an information campaign and the location of a specific brown container for biowaste in specific zones of the city was carried out in Castellón de la Plana (Spain) over a period of six months. In this period, the collection and composition of the biowaste was monitored in depth with the goal of determining the evolution of the efficiency of the new collection system over time. Results:In the zones, the quality rate in the biowaste container increased as the pilot study progressed, finally reaching 90%. The rate of biowaste separation also increased in the three zones over time, although in different ways, which means that there is greater collaboration on the part of citizens. On the other hand, an analysis of the rate of net biowaste daily collection from zones 2 and 3 has shown that their value increases as the rate of containerization of biowaste decreases. Conclusions:In order to obtain better results in the biowaste quality rate it will be necessary to increase the containerization of biowaste, that is, to reduce the distance from the citizen to the container. It can thus be said that there is a positive evolution of the experience, which boosts confidence when it comes to implementing the system throughout the city.
Ion Exchange Behavior of Natural Zeolites in Distilled Water, Hydrochloric Acid, and Ammonium Chloride Solution

This study presents basic research on the use of natural zeolites for the removal of ammonium ions from aqueous solutions. Three natural zeolites from Shimane, Japan, used in this study are shown to contain varying amounts of clinoptilolite and mordenite. The chemical behavior of these natural zeolites was investigated in distilled water, hydrochloric acid, and ammonium chloride solution. The amount of ammonium ions adsorbed by these zeolites was measured using an electrode specific to ammonium ion. The results were compared with published adsorption values for other zeolites. Hydrogen ions displaced the exchangeable cations (Na+, K+, Ca2+, and Mg2+) on the natural zeolites in distilled water and hydrochloric acid. With the decrease in equilibrium pH, the amounts of dissolved silica and alumina increased. This behavior indicates that the structures of the zeolites are damaged under this condition. Ammonium ions were preferentially adsorbed on the natural zeolites in ammonium chloride solution. The amount of ammonium ions adsorbed quantitatively corresponded to the theoretically expected amount at high ammonium concentrations. This result indicates that ammonium adsorption occurs by ion exchange of ammonium ions with Na+, K+, Mg2+, and Ca2+ in cation exchange sites on zeolites. The order of selectivity of ammonium ions for other cations on the zeolites was Na+≫K+>Ca2+>Mg2+. Ammonium adsorption was the highest in the zeolite containing the highest proportion of clinoptilolite of the three natural zeolites. The maximum adsorption was 1.28 mmol/g.
FESEM and EIS Study of Sealed AA2024 T3 Anodized in Sulfuric Acid Electrolytes : Influence of Tartaric Acid

The present study investigates the effect of tartaric acid on anodic film morphology and on corrosion resistance of hydrothermally sealed anodized AA2024. Anodizing treatment was performed in dilute sulfuric acid electrolyte with or without addition of tartaric acid. Hydrothermal sealing was carried out in boiling water for each anodized specimen. The morphology of the sealed anodic films was examined using field-emission scanning electron microscopy (FESEM). Electrochemical impedance spectroscopy (EIS) was performed to assess sealing quality and corrosion resistance of the anodic films. It was shown that the sealing was more efficient in the case of anodic films formed in tartaric acid electrolyte mainly due to their lower porosity. It was also observed that the properties of the barrier layer were higher when sealing was performed on specimens anodized in the presence of tartaric acid. This suggests a specific role of the species on the barrier layer, which contributes to the enhancement of the performance in terms of corrosion resistance of the sealed anodic films. The present study clearly validates the beneficial role of tartaric acid in anodizing baths for the corrosion protection of AA2024.
Thermal behavior of lithium‐ion battery in microgrid application: Impact and management system

Safe and reliable operation is among the considerations when integrating lithium‐ion batteries as the energy storage system in microgrids. A lithium‐ion battery is very sensitive to temperature in which it is one of the critical factors affecting the performance and limiting the practical application of the battery. Furthermore, the adverse effects differ according to the temperature. The susceptibility of lithium‐ion battery to temperature imposes the need to deploy an efficient battery thermal management system to ensure the safe operation of the battery while at the same time maximizing its performance and life cycle. To design a good thermal management system, accurate temperature measurement is vital to assist the battery thermal management system in managing relevant states such as the stage‐of‐charge and state‐of‐health of the battery. This article outlines the effects of low and high temperatures on the performance of Li‐ion batteries. Next, a review of currently available internal temperature monitoring approaches is presented based on their feasibility and complexity. Then, an overview of battery thermal management systems based on different cooling mediums is presented. This includes air cooling, liquid cooling, phase change material (PCM) cooling, heat pipe cooling, boiling‐based cooling, and solid‐state cooling. The final section of this article discusses the practical implementation of the internal temperature measurement approach and battery thermal management system for microgrids. From the review, a suitable candidate is the flexible, low maintenance, and long lifetime hybrid battery thermal management system that combines heat pipe cooling and solid‐state cooling. It is capable of maintaining the maximum operating temperature of the battery within 45°C at up to 3C discharge rate while being a relatively simple system. Additionally, passive PCM with thermally conductive filler can also be employed to assist the hybrid battery thermal management system in improving the temperature uniformity well within 5°C.
Reviving the genitive. Prescription and practice in the Netherlands (1770–1840)

Abstract Historical metalinguistic discourse is known to often prescribe linguistic variants that are not very frequent in actual language use, and to proscribe frequent variants. Infrequent variants that are promoted through prescription can be innovations, but they can also be conservative forms that have already largely vanished from the spoken language and are now also disappearing in writing. An extreme case in point is the genitive case in Dutch. This has been in decline in usage from at least the thirteenth century onwards, gradually giving way to analytical alternatives such as prepositional phrases. In the grammatical tradition, however, a preference for the genitive case was maintained for centuries. When ‘standard’ Dutch is officially codified in 1805 in the context of a national language policy, the genitive case is again strongly preferred, still aiming to ‘revive’ the synthetic forms. The striking discrepancy between metalinguistic discourse on the one hand, and developments in language use on the other, make the genitive case in Dutch an interesting case for historical sociolinguistics. In this paper, we tackle various issues raised by the research literature, such as the importance of genre differences as well as variation within particular genres, through a detailed corpus-based analysis of the influence of prescription on language practices in eighteenth- and nineteenth-century Dutch.