Miracle-dz/UniFAR-FTUs huggingface dataset:
Determinants of perivascular adipose tissue stranding as a novel imaging marker and its relation to inflammatory biomarker high-sensitivity C-reactive protein

Purpose This study aimed to examine the relationship of perivascular adipose tissue (PVAT) stranding in coronary computed tomography angiography (CCTA) with high-sensitivity C-reactive protein (hsCRP) and the determinants of PVAT stranding in coronary artery disease (CAD) patients. Material and methods This retrospective cross-sectional study was done by collecting data from CAD patients who were referred to Rajaie Cardiovascular Centre between January 2018 and September 2020, with CCTA and hsCRP test 72 hours apart from the CCTA. PVAT stranding was defined as irregular obscuration of PVAT adjacent to the coronary arteries. An attempt was made to find a correlation between included variables and PVAT stranding by comparing them between 2 groups: patients with and without PVAT stranding. Results From 92 patients, 31 participants had PVAT stranding, and statistically significant higher levels of hsCRP were detected in them (p = 0.007). We demonstrated significantly higher prevalence of history of hyperlipidaemia (OR = 3.83, p = 0.029), high-risk plaque features (OR = 11.80, p = 0.015), and obstructive coronary luminal stenosis (OR = 3.25, p = 0.025) in patients with PVAT stranding. Also, significantly higher PVAT attenuation was detected in patients with PVAT stranding (p < 0.001) independently from mean attenuation of epicardial fat. Conclusion PVAT stranding could be used as a novel non-invasive marker in CCTA of CAD patients. More studies focusing on patient outcomes are required to better evaluate the reliability and prognostic value of this marker.
Neurodynamic Approaches to Multiple Constrained Distributed Resource Allocation With Planned or Self-Regulated Demand

In industrial intelligent manufacturing processes, restricted by resources and transmission lines, many problems can be described as distributed optimization problems that need to be solved cooperatively on the premise of resource sharing, i.e., distributed resource allocation (DRA). In this article, several neurodynamic approaches are proposed to solve multiple constrained DRAs with planned or self-regulated demand over switched communication topologies. In the problems considered, the planned demand is the well-studied fixed resource demand, and the self-regulated demand refers to the scenario where the demand of users may change unpredictably. To solve DRAs with two different demands mentioned above and the multiple coupled constraints distributedly, a finite-time tracking technique and fixed-time projection technology are utilized such that local Lagrange multipliers reach consensus in finite time. It is proved that the proposed neurodynamic approaches are able to address the coupled equality and nonlinear inequality constraints simultaneously, and the states of agents along each neurodynamic approach asymptotically converge to an optimal solution to the related problem. Finally, a smart grid application is provided to verify the effectiveness of the proposed neurodynamic approaches and demonstrate the advantage of self-regulated demand over planned demand.
NON-ABELIAN HOMOLOGY OF LIE ALGEBRAS

Non-abelian homology of Lie algebras with coefficients in Lie algebras is constructed and studied, generalising the classical Chevalley-Eilenberg homology of Lie algebras. The relationship between cyclic homology and Milnor cyclic homology of non-commutative associative algebras is established in terms of the long exact non-abelian homology sequence of Lie algebras. Some explicit formulae for the second and the third non-abelian homology of Lie algebras are obtained.
Sprinting in a Marathon: Nursing Staff and Nurse Leaders Make Meaning of Practicing in COVID-19 Devoted Units Pre-Vaccine

Objective To describe the lived experience of nursing staff and nurse leaders working in COVID-19 devoted units (intensive care or medical unit) prior to vaccine availability. Research Design Qualitative phenomenological design with a focus group approach. Methods The study team recruited a convenience sample of nursing staff (nurses, and nursing assistants/nurse technicians) and nurse leaders (managers, assistant nurse managers, clinical nurse specialists, and nurse educators) at an academic medical center in the midwestern United States. Focus groups and individual interviews were conducted to encourage participants to describe their (1) experiences as nursing professionals, (2) coping strategies, and (3) perspectives about supportive resources. Moral distress was measured with the moral distress thermometer and qualitative data were analyzed with Giorgi-style phenomenology. Results We conducted 10 in-person focus groups and five one-on-one interviews (n = 44). Seven themes emerged: (1) the reality of COVID-19: we are sprinting in a marathon; (2) acute/critical care nurse leaders experience unique burdens; (3) acute/critical care staff nurses experience unique burdens; (4) meaning of our lived experience; (5) what helped us during the pandemic; (6) what hurt us during the pandemic; and (7) we are not okay. Participants reported a moderate level of moral distress (M = 5.26 SD = 2.31). They emphasized that peer support was preferred over other types of support offered by the healthcare organization. Participants expressed positive feedback about the focus group experience and commented that group processing validated their experiences and helped them “feel heard. ” Conclusion These findings affirm the need for trauma-informed care and grief support for nurses, interventions that increase meaning in work, and efforts to enhance primary palliative communication skills. Study findings can inform efforts to tailor existing interventions and develop new, more comprehensive resources to meet the psychosocial needs of nursing staff and nurse leaders practicing during a pandemic.
Stability switches for some class of delayed population models

We study stability switches for some class of delay diﬀerential equations with one discrete delay. We describe and use a simple method of checking the change of stability which originally comes from the paper of Cook and Driessche (1986). We explain this method on the examples of three types of prey-predator models with delay and compare the dynamics of these models under increasing delay.
Recent improvements in PEEC modeling accuracy

The partial element equivalent circuit (PEEC) technique is a circuit based formulation which is numerically equivalent to a full wave method of moments solution with Galerkin matching. In this paper, numerical improvements are made to the PEEC formulation through a partitioning scheme that increases the solution accuracy without increasing the number of unknowns. This partitioning scheme is useful in both the time and frequency domain. In addition, in the time domain, integral equation techniques have stability problems due either to the numerical technique used, or to problems created by the discrete representation of the numerical solution of the problem. This parititioning technique can be used to eliminate the instabilities due to the discrete representation of the numerical solution. This work is of particular interest when using model reduction techniques and also for time domain analysis where the late time instability is well known.
Filling the Gap after CDK4/6 Inhibitors: Novel Endocrine and Biologic Treatment Options for Metastatic Hormone Receptor Positive Breast Cancer

Simple Summary There are limited treatment options beyond chemotherapy for patients with hormone receptor positive metastatic breast cancer after progression on first line therapy with CDK4/6 inhibitors and endocrine therapy. Recently, encouraging evidence has emerged from multiple drugs in this space with the potential to delay chemotherapy and improve outcomes. The most promising agents include the AKT inhibitor capivasertib, the oral selective estrogen receptor degrader (SERD) elacestrant, and PARP inhibitors for patients harboring pathogenic germline BRCA1/2 mutations. Additionally, a subset of patients may also potentially be candidates for continuation of CDK4/6 inhibitors beyond progression. In this review, we highlight clinical data supporting the use of these agents and critically analyze the available evidence for their use. We also provide an algorithm to guide clinicians in their daily practice for patients with progression following first line CDK4/6 inhibitors and endocrine therapy. Abstract The rise of cyclin-dependent kinase (CDK)4/6 inhibitors has rapidly reshaped treatment algorithms for hormone receptor (HR)-positive metastatic breast cancer, with endocrine treatment (ET) plus a CDK4/6-inhibitor currently representing the standard of care in the first line setting. However, treatment selection for those patients experiencing progression while on ET + CDK4/6-inhibitors remains challenging due to the suboptimal activity or significant toxicities of the currently available options. There is also a paucity of data regarding the efficacy of older regimens, such as everolimus + exemestane, post-CDK4/6 inhibition. In this setting of high unmet need, several clinical trials of novel drugs have recently reported encouraging results: the addition of the AKT-inhibitor capivasertib to fulvestrant demonstrated a significant improvement in progression-free survival (PFS); the oral selective estrogen receptor degrader (SERD) elacestrant prolonged PFS compared to traditional ET in a phase 3 trial, particularly among patients with detectable ESR1 mutations; finally, PARP inhibitors are available treatment options for patients with pathogenic BRCA1/2 germline mutations. Overall, a plethora of novel endocrine and biologic treatment options are finally filling the gap between first-line ET and later line chemotherapy. In this review article, we recapitulate the activity of these novel treatment options and their potential role in future treatment algorithms.
Analysis and synthesis of impedance plane

The problem of synthesis of an impedance plane reflecting a homogeneous plane wave in a given direction is solved. The law of distribution of impedance is found in analytical form. The restrictions on the class of the allowable scattering patterns are formulated. A rigorous solution of the problem of wave scattering by a plane with non-uniform periodic reactance is obtained in analytically closed form.
Impact of Co-Occurrence of Obesity and SARS-CoV-2 Infection during Pregnancy on Placental Pathologies and Adverse Birth Outcomes: A Systematic Review and Narrative Synthesis

Obesity is a risk factor for severe COVID-19 disease during pregnancy. We hypothesized that the co-occurrence of high maternal body mass index (BMI) and gestational SARS-CoV-2 infection are detrimental to fetoplacental development. We conducted a systematic review following PRISMA/SWiM guidelines and 13 studies were eligible. In the case series studies (n = 7), the most frequent placental lesions reported in SARS-CoV-2(+) pregnancies with high maternal BMI were chronic inflammation (71.4%, 5/7 studies), fetal vascular malperfusion (FVM) (71.4%, 5/7 studies), maternal vascular malperfusion (MVM) (85.7%, 6/7 studies) and fibrinoids (100%, 7/7 studies). In the cohort studies (n = 4), three studies reported higher rates of chronic inflammation, MVM, FVM and fibrinoids in SARS-CoV-2(+) pregnancies with high maternal BMI (72%, n = 107/149; mean BMI of 30 kg/m2) compared to SARS-CoV-2(−) pregnancies with high BMI (7.4%, n = 10/135). In the fourth cohort study, common lesions observed in placentae from SARS-CoV-2(+) pregnancies with high BMI (n = 187 pregnancies; mean BMI of 30 kg/m2) were chronic inflammation (99%, 186/187), MVM (40%, n = 74/187) and FVM (26%, n = 48/187). BMI and SARS-CoV-2 infection had no effect on birth anthropometry. SARS-CoV-2 infection during pregnancy associates with increased prevalence of placental pathologies, and high BMI in these pregnancies could further affect fetoplacental trajectories.
Calibration method to improve the accuracy of THz imaging and spectroscopy in reflection geometry

We introduce a novel method to accurately extract the optical parameters in terahertz reflection imaging. Our method builds on standard self-referencing methods using the reflected signal from the bottom of the imaging window material to further compensate for time-dependent system fluctuations and position-dependent variation in the window thickness. Our proposed method not only improves the accuracy, but also simplifies the imaging procedure and reduces measurement times.
Correlation of Redondovirus and Entamoeba gingivalis Detections in the Human Oral Cavity Suggests That This Amoeba Is Possibly the Redondovirus Host

The virome of the human oral cavity and the relationships between viruses and diseases such as periodontitis are scarcely deciphered. Redondoviruses were reported in the human oral cavity in 2019, including in periodontitis patients. Here, we aimed at detecting redondoviruses and at searching for a potential viral host in human saliva. Non-stimulated saliva was collected between December 2020 and June 2021. These samples were tested using real-time PCR regarding the presence of redondovirus and Entamoeba gingivalis DNA. Similarity searches were performed using BLAST against eukaryotic and prokaryotic sequences from GenBank. The redondovirus DNA was detected in 46% of the 28 human saliva samples. In addition, short fragments of redondovirus genomes were detected in silico within Entamoeba sequences. Finally, Entamoeba gingivalis DNA was detected in 46% of the 28 saliva samples, with a strong correlation between redondovirus DNA and E. gingivalis DNA detections, in 93% of the cases. Regarded together, these findings and previous ones strongly support the presence of redondoviruses in the human oral cavity and their association to E. gingivalis as their likely host.
Neoadjuvant immunotherapy in resectable non-small-cell lung cancer

The advent of immune checkpoint inhibition has pushed the treatment paradigm for resectable non-small-cell lung cancer (NSCLC) toward neoadjuvant therapy. A growing number of promising trials have examined the utility of neoadjuvant immunotherapy, both alone and in combination with other modalities such as radiation therapy (RT) and chemotherapy. The phase II LCMC3 and NEOSTAR trials demonstrated a role for neoadjuvant immunotherapy in inducing meaningful pathologic responses, and another phase II trial established the feasibility of combining neoadjuvant durvalumab with RT. Significant interest in neoadjuvant chemoimmunotherapy resulted in the conduct of multiple successful phase II trials including the Columbia trial, NADIM, SAKK 16/14, and NADIM II. Across these trials, neoadjuvant chemoimmunotherapy led to high rates of pathologic response and improved surgical outcomes without compromising surgical timing or feasibility. CheckMate-816, which was a randomized phase III trial studying neoadjuvant nivolumab in addition to chemotherapy, definitively established a benefit for neoadjuvant chemoimmunotherapy compared to chemotherapy alone for resectable NSCLC. Despite the growing literature and success of these trials, several outstanding questions remain, including the relationship between pathologic response and patient survival, the role of biomarkers such as programmed death ligand 1 and circulating tumor DNA in determining patient selection and treatment course, and the utility of additional adjuvant therapies. Longer follow-up of CheckMate-816 and other ongoing phase III trials may help address these questions. Ultimately, the complexity of managing resectable NSCLC highlights the importance of a multidisciplinary approach to patient care.
PILOTE: Linear Quadratic Optimal Controller for Irrigation Canals

Linear quadratic optimal control theory is applied to the automatic control of two different eight-pool irrigation canals. The model used to design the controller is derived from the Saint-Venant equations discretized through the Preissmann implicit scheme. The linear quadratic closed-loop optimal controller is obtained from steady-state solution of the matrix Riccati equation. A Kalman filter reconstructs the state variables and the unknown perturbations from a reduced number of measured variables. Both perturbation rejection and tracking aspects are incorporated in the controller. Known offtake withdrawals and future targets are anticipated through an open-loop scheme utilizing time varying solutions of the linear quadratic optimization problem. The controller and Kalman filter are tested on a full nonlinear model and prove to be stable, robust, and precise.
Extragalactic Survey of UV Galaxies Using GALEX

We report here the results of the study of extragalactic radiation using number counts of galaxies at high galactic latitudes. For this study nine G A L E X DIS targets around ELAISN1 in the North Pole. The overlapped regions of two missions cover an area of ~2 square degrees in the selected region. By comparing the point source catalogs of GALEX and Spitzer, we obtained the UV flux (both FUV & NUV) in magnitude for each matching galaxy. We then calculated the number counts of galaxies, N Objects/square degree/magnitude, from the region and compared it with the existing values in the literature. There is drop out of galaxies at the fainter end which is due to low resolution and sensitivity of GALEX when we compared it with Spitzer Extragalactic Representative Volume Survey (SERVS) region - ELIAS-N1 - centered at 16 h 10 m 01 s , +54°30'36". From this study we could establish the presence of unresolved objects in the GALEX field.
Surge instability on a cavitating propeller

This study details experiments investigating a previously unrecognized surge instability on a cavitating propeller in a water tunnel. The surge instability is explored through visual observation of the cavitation on the propeller blades and in the tip vortices. Similarities between the instability and previously documented cavitation phenomena are noted. Measurements of the radiated pressure are obtained, and the acoustic signature of the instability is identified. The magnitudes of the fluctuating pressures are very large, presumably capable of producing severe hull vibration on a ship. The origins of this instability are explored through separate investigation of the cavitation dynamics and the response of the water tunnel to volumetric displacement in the working section. Experiments are conducted to quantify the dynamics of the propeller cavitation. Finally, a model is developed for the complete system, incorporating both the cavitation and facility dynamics. The model predicts active system dynamics (linked to the mass flow gain factor familiar in the context of pump dynamics) and therefore potentially unstable behaviour for two distinct frequency ranges, one of which appears to be responsible for the instability.
Hurwitz spaces of genus 2 covers of an elliptic curve

Let $E$ be an elliptic curve over a field $K$ of characteristic $\not =$ 2 and let $N > 1$ be an integer prime to char ($K$). The purpose of this paper is to construct the (twodimensional) Hurwitz moduli space $H (E / K, N, 2)$ which "classifies" genus 2 covers of $E$ of degree $N$ and to show that it is closely related to the modular curve $X$ ($N$) which parametrizes elliptic curves with level -$N$- structure. \newline More precisely, we introduce the notion of a normalized genus 2 cover of $E / K$ and show that the corresponding moduli space is $H_{E / K, N}$ is an open subset of (a twist of) $X$ ($N$), and that the connected components of the Hurwitz space $H (E/K, N, 2)$ are of the form $E\times H_{E'/K,M}$ for suitable elliptic curves $E'\sim E$ and divisors $M\vert N$.
Efficacy and Safety of Bedside Removal of Tunnelled Hemodialysis Catheter by Noninterventional Nephrologists among Adult Patients in the King Abdulaziz University Hospital Hemodialysis Centre in Jeddah: A Retrospective Cohort Study

This study aimed to assess the efficacy and safety of bedside removal of tunnelled hemodialysis catheter (TDC) by noninterventional nephrologists among adult patients. It is a retrospective study that involved 53 patients from March 2020 to February 2022 at the King Abdulaziz University Hospital (KAUH) Hemodialysis Centre in Jeddah, Saudi Arabia. Of the 53 participants, 60.4% were male and 40.6% female, and their mean age was 50.94 ± 18.89 years. The most common comorbidities were hypertension (HTN) in 47 (88.7%), diabetes mellitus (DM) in 24 (45.3%), and DM and HTN together in 23 (43.4%) patients. The most common site of TDC removal was the right internal jugular vein (77.4%). In 84.9% of the cases, the TDC was removed as an inpatient procedure, and in the majority of the cases (64.2%), the TDC was removed by a noninterventional nephrologist. The most common reasons for TDC removal were sepsis or clinical concerns for infection (64.2%) and TDC not needed (20.8%) due to recovery of the renal function or access maturation. Most patients (96.2%) suffered no complications; only one of 34 (%) patients with catheter removal by a noninterventional nephrologist had bleeding, which required more observation and monitoring before discharge on the same day. Our study revealed that the bedside TDC removal was well tolerated with a minimal complication rate.
SALAMAN; The Innovation of Demography Services in Bandung City.

The purpose of this study is to examine the innovations by the government of Bandung City in providing demography services for the community. Salaman is an application made by the Bandung City Government to facilitate the community in demography administration. Through this application, we can complete all administrative we needs through our gadgets. But on the other hand there are still people who are constrained in using this application. This study uses a descriptive method with a qualitative approach. The research results show that the success of this application depends on the participation of the community in using it. There are still people who are reluctant to use this application due to a lack of understanding in its use.
Detection of Inverse-Compton X-Rays from Lobes of the Radio Galaxy Fornax A

Extended X-ray emission was detected with ASCA from the synchrotron double lobes of the radio galaxy Fornax A. This is thought to be the same emission as was detected with ROSAT. The excess X-rays exhibit very hard spectra, described by a power law of energy index 1.2 ± 0.5. Since this index is consistent with the synchrotron radio index of 0.9 ± 0.2, the X-rays are thought to arise when the radio-emitting relativistic electrons make inverse-Compton scattering off the cosmic microwave photons. Comparison of the X-ray and radio fluxes yields the lobe magnetic field intensity of 2-4 μG. The relativistic electrons in the lobes are inferred to have an energy density close to that of the magnetic fields.