Miracle-dz/UniFAR-FTUs huggingface dataset:
MYC overrides HIF-1α to regulate proliferating primary cell metabolism in hypoxia

Hypoxia requires metabolic adaptations to sustain energetically demanding cellular activities. While the metabolic consequences of hypoxia have been studied extensively in cancer cell models, comparatively little is known about the metabolic response of primary cells to hypoxia. We performed metabolic flux analyses of proliferating human lung fibroblasts and pulmonary artery smooth muscle cells in hypoxia. Unexpectedly, hypoxia decreased glycolytic flux despite activation of hypoxia-inducible factor (HIF) and increased glycolytic enzyme expression. Pharmacologic activation of HIF with the prolyl hydroxylase (PHD) inhibitor molidustat in normoxia did increase glycolytic flux, but hypoxia abrogated this effect. Multi-omic profiling revealed distinct molecular responses to hypoxia and pharmacologic PHD inhibition and suggested a critical role for MYC in modulating the HIF response in hypoxia. MYC knockdown in hypoxia increased lactate efflux, while MYC overexpression in normoxia blunted the effects of molidustat treatment. Together, these data suggest that other factors, notably MYC, supersede the anticipated effects of HIF-dependent up-regulation of glycolytic gene expression on glycolytic flux in hypoxic proliferating primary cells.
Mode-division Multiplexed Transmission In Few-mode Fibers

As a promising candidate to break the single-mode fiber capacity limit, mode-division multiplexing (MDM) explores the spatial dimension to increase transmission capacity in fiberoptic communication. Two linear impairments, namely loss and multimode interference, present fundamental challenges to implementing MDM. In this dissertation, techniques to resolve these two issues are presented. To de-multiplex signals subject to multimode interference in MDM, Multiple-InputMultiple-Output (MIMO) processing using adaptive frequency-domain equalization (FDE) is proposed and investigated. Both simulations and experiments validate that FDE can reduce the algorithmic complexity significantly in comparison with the conventional time-domain equalization (TDE) while achieving similar performance as TDE. To further improve the performance of FDE, two modifications on traditional FDE algorithm are demonstrated. i) normalized adaptive FDE is applied to increase the convergence speed by 5 times; ii) masterslave carrier recovery is proposed to reduce the algorithmic complexity of phase estimation by number of modes. Although FDE can reduce the computational complexity of the MIMO processing, due to large mode group delay (MGD) of FMF link and block processing, the algorithm still requires enormous memory and high hardware complexity. In order to reduce the required tap length (RTL) of the equalizer, differential mode group delay compensated fiber (DMGDC) has been proposed. In this dissertation, the analytical expression for RTL is derived for DMGDC systems under the weak mode coupling assumption. Instead of depending on the overall MGD of the link
Authors Reply: Empathy and Creativity: Dangers of the Methodological Tail Wagging the Conceptual Dog

The three commentaries on “Why We Should Reject the Restrictive Isomorphic Matching (RIM) Definition of Empathy” mostly concurred with our critique of that widely adopted definition of empathy. Yet, commenters also raised important questions relating to the clarity and operationalizability of our recommended alternative: returning to a classical conceptualization of empathy as a dynamic, functionally oriented, multi-faceted unfolding process. To help contextualize these issues, we provide an extended analogy between empathy research and creativity research, areas of study which are conceptually linked and have faced similar conceptual and methodological obstacles. In doing so, we highlight the challenge of (a) distilling empathy down to a firm operationalizable definition without (b) losing sight of the general meaning and real-world value of the construct.
Contrast-Enhanced Mammography versus Breast Magnetic Resonance Imaging: A Systematic Review and Meta-Analysis

Background: Contrast-enhanced mammography (CEM) and contrast-enhanced magnetic resonance imaging (CE-MRI) are commonly used in the screening of breast cancer. The present systematic review aimed to summarize, critically analyse, and meta-analyse the available evidence regarding the role of CE-MRI and CEM in the early detection, diagnosis, and preoperative assessment of breast cancer. Methods: The search was performed on PubMed, Google Scholar, and Web of Science on 28 July 2021 using the following terms “breast cancer”, “preoperative staging”, “contrast-enhanced mammography”, “contrast-enhanced spectral mammography”, “contrast enhanced digital mammography”, “contrast-enhanced breast magnetic resonance imaging” “CEM”, “CESM”, “CEDM”, and “CE-MRI”. We selected only those papers comparing the clinical efficacy of CEM and CE-MRI. The study quality was assessed using the QUADAS-2 criteria. The pooled sensitivities and specificity of CEM and CE-MRI were computed using a random-effects model directly from the STATA “metaprop” command. The between-study statistical heterogeneity was tested (I2-statistics). Results: Nineteen studies were selected for this systematic review. Fifteen studies (1315 patients) were included in the metanalysis. Both CEM and CE-MRI detect breast lesions with a high sensitivity, without a significant difference in performance (97% and 96%, respectively). Conclusions: Our findings confirm the potential of CEM as a supplemental screening imaging modality, even for intermediate-risk women, including females with dense breasts and a history of breast cancer.
Sinha's spectral sequence and homotopical algebra of operads

Lambrechts, Turchin and Volic proved the Bousfield-Kan type rational homology spectral sequence associated to the d-th Kontsevich operad collapses at E^2-page if d>=4. The key of their proof is formality of the operad. In this paper, we simplify their proof using a model category of operads. As byproducts, we obtain two new consequences. One is collapse of the spectral sequence in the case of d=3 (and the coefficients being rational numbers). The other says there is no non-trivial extension for the Gerstenhaber algebra structure on the spectral sequence.
Concomitant thrombosis in patients with cellulitis as incidental finding.

BACKGROUND Although inflammation and thrombosis are tightly connected, only 45% of patients with lower leg cellulitis receive anticoagulant therapy. Available data about the prevalence of concomitant deep venous thrombosis (DVT) in patients with cellulitis of the lower extremity is scarce and general guidelines regarding diagnosis and prevention of venous thromboembolism are missing. OBJECTIVE We sought to determine how frequently DVT occurs as an incidental finding in patients with cellulitis and to provide recommendations for diagnostics and anticoagulant therapy. METHODS Patients' records were analysed and 192 consecutive patients with cellulitis were included in this study. The prevalence of concomitant DVT was examined by duplex ultrasound, as well as comorbidities and risk factors. RESULTS We detected thrombosis in 12.0% of the patients with lower leg cellulitis, of which 43.5% were located in a proximal vein and 52.2% in the veins of the calf. CONCLUSIONS Our results clearly indicate that cellulitis is not only a differential diagnosis, but should be considered a risk factor for venous thrombosis. Therefore, prophylactic anticoagulation should be considered in patients suffering from cellulitis and a systematic screening for venous thrombosis in patients with cellulitis should be performed.
Influence of coaches’ motivating style on motivation, and sport commitment of young water polo players

Coaches’ motivating style plays a key role in athletes’ motivational outcomes. However, limited research has explored the effects of athletes’ perceptions of coaches’ need-supportive and controlling styles on the bright and dark motivational pathways in the sport setting, and particularly in young water polo players, where one out of two players drops out of this sport as adults. Guided by self-determination theory, the objective of this study was to analyse the differentiated effects between water polo players’ perception of need-supportive and controlling style from their coaches on their reported basic psychological need satisfaction and frustration, motivation and sport commitment. In this cross-sectional study, 633 Spanish water polo players (33.96% women; Mage = 14.74), from 43 clubs and three age groups (U-14, U-16 and U-18) completed validated questionnaires assessing study variables. Structural equation modelling showed a positive association of players’ perceptions of need-supportive style from their coaches with their reported need satisfaction, autonomous motivation and sport commitment. Similarly, perceived controlling coaching style was positively associated with reported need frustration, controlled motivation and amotivation. Regarding cross-paths, perceived need-supportive coaching style was negatively related to reported need frustration, while reported amotivation was negatively associated with reported sport commitment. These findings suggest the importance of water polo players’ perceptions of (de)motivating styles from their coaches on their reported motivational outcomes and sport commitment. Players’ perception of coach need-supportive behaviours and, in particular, the avoidance of perceived controlling behaviours, buffer against experiences of reported need frustration and, consequently, amotivation, which seems to play a key role in preventing lack of sport commitment in young water polo players.
Prevention of initiation of smokeless tobacco (SLT) consumption among rural children

Background: India Global Youth Tobacco Survey 2019 observed that 8.5% of the young age group (13-15 years) consume tobacco (9.6 % are boys and 7.4 % are girls). No interventional studies among adolescents were conducted before the initiation of the SLT use. Aims & Objectives: To estimate the prevalence of consumption of tobacco and non-tobacco products and to provide school based interventions to bring behavioral changes. Materials and Methods: An interventional study was carried out in Primary Schools. For estimation of the prevalence of tobacco and non tobacco use all the students of 1st to 5th while for the interventions, 4th and 5th standard were selected. Baseline data and change in the behavior at the end of one year was collected. FGD with key informants were also conducted. Descriptive Statistics was conducted. Results: The prevalence of smokeless tobacco consumption and non-tobacco product was found to be 1.3% and 36.5% respectively. After intervention 40.5% students had quit non tobacco products. Findings of FGD suggested that children should not be sent to purchase tobacco products on behalf of their parents. Conclusion: School based intervention and sensitization of the field workers along with knowing their perceptions for the predictors of consumption could be useful.
The relationship between cognition, education, and employment in multiple sclerosis patients

Background Processing speed decline is a common manifestation of multiple sclerosis (MS). The processing speed test (PST) is a validated electronic cognitive assessment based on the Symbol–Digit Modalities Test, which is routinely administered as part of the multi-institutional Multiple Sclerosis Partners Advancing Technology and Health Solutions (MS PATHS) initiative. The longitudinal relationship between education, processing speed, and employment is unclear. Objectives Determine the longitudinal impact of educational attainment on processing speed and employment. Methods MS PATHS data through March 2020 were analyzed. Repeat PST assessments at 1, 2, and 3 years were classified as improved, worsened, or stable. Linear regression was used to evaluate the relationship between education and baseline PST performance and logistic regression was used to determine the odds of PST worsening by educational attainment. Employment outcomes were analyzed by PST status and educational level. Results There were 13,732 patients analyzed. Education impacted baseline PST scores, but had a limited effect on PST performance over time. Education was protective with respect to employment in the setting of both PST worsening and improvement. Conclusion Greater education results in better baseline processing speed and is protective with respect to employment status. Its impact on processing speed over time is marginal.
Association of Butyrophilin gene polymorphism (A465G) with milk production traits in Holstein Friesian crossbred cattle of Kerala

The butyrophilin (BTN1A1) gene is found at a quantitative trait locus (QTL) in cattle for milk production traits. The effect of a single nucleotide polymorphism (SNP) A465G in exon 8, which causes a lysine to arginine transition, on milk production attributes in Holstein Friesian crossbred cattle from Kerala was investigated in this study (151 numbers). Using custom synthesised primers, a 90-bp fragment encompassing the polymorphic region was amplified from genomic DNA isolated.Genotyping was carried out by high resolution melt curve analysis (HRM) and two genotypes KK (0.25) and KL (0.75) were detected based on melting temperature and melt curve patterns.Sanger’s sequencing and sequence analysis of representative samples confirmed the genotypes.Chi-square test showed that the population was not distributed as per Hardy-Weinberg equilibrium(p≤0.05). The relationship between the A465G transition and milk production traits like 305 daymilk, fat, SNF yields, fat and SNF per cent was determined by general linear model-analysis of variance (GLM-ANOVA). In the model herd, season of calving, parity of animal (non-geneticfactors), and genotype were considered fixed variables and milk production traits as dependent variable. The study revealed significantly higher (p≤0.01) milk fat and SNF per cent for KK genotype(4.14±0.08 %; 7.86±0.06 %) than KL genotype (3.91±0.07 %; 7.73±0.05 %). The butyrophilin genepolymorphism (A465G) can be recommended as a marker for higher milk fat and SNF per cent infuture breeding programmes in crossbred cattle of Kerala.
Averaging and Stacking Partial Least Squares Regression Models to Predict the Chemical Compositions and the Nutritive Values of Forages from Spectral Near Infrared Data

Partial least square regression (PLSR) is a reference statistical model in chemometrics. In agronomy, it is used to predict components (response variables y) of chemical composition of vegetal materials from spectral near infrared (NIR) data X collected from spectrometers. PLSR reduces the dimension of the spectral data X by defining vectors that are then used as latent variables (LVs) in a multiple linear model. One difficulty is to determine the relevant dimensionality (number of LVs) for the given data. This step can be very time consuming when many datasets have to be processed and/or the datasets are frequently updated. The paper focuses on an alternative, bypassing the determination of the PLSR dimensionality and allowing for automatizing the predictions. The strategy uses ensemble learning methods, such as averaging or stacking the predictions of a set of PLSR models with different dimensionalities. The paper presents various methods of PLSR averaging and stacking and compares their performances to the usual PLSR on six real datasets on different types of forages. The main finding of the study was the overall superiority of the averaging methods compared to the usual PLSR. We therefore believe that such methods can be recommended to analyze NIR data on forages.
Effect of Variable Seed Rates on Crop Growth Rate (CGR) and Seed Yield of different Field Pea (Pisum sativum L.) Genotypes at New Alluvial Zone of West Bengal

The field experiment was conducted at District Seed Farm, ‘A-B’ block, of Bidhan Chandra Krishi Viswavidyalaya, Kalyani, Nadia, West Bengal, India, during two subsequent rabi (winter) seasons (November – March) of 2018-19 and 2019-20, to evaluate the growth rate and seed yield of field pea genotypes under varying seed rates at New Alluvial Zone of West Bengal. The experiment was laid out in a split plot design with two different seed rates (80 kg ha -1 & 100 kg ha -1 ) and five different genotypes (HUDP 15, SKNP 04-09, IPF 16-13, VL 42, TRCP 8) as primary and subplot factors respectively. Based on pooled data of two-year investigations, higher seed rate treatment (seed rate 100 kg/ha) always recorded a superior growth rate compared to lower seed rate treatment (seed rate 80 kg/ha). Still, contradictorily, lower seed rate recorded higher seed yields. This implies optimum plant population is a crucial practice to obtaining higher seed yield. In the case of variable genotypes, the highest CGR has been observed in SKNP 04-09 genotype during the interval of 60-90 DAS, and the highest seed yield was recorded in the case of IPF 16-13 genotype. The combination of genotype IPF 16-13 and HUDP 15 along with a seed rate of 80 kg/ha are economically profitable options for better production in terms of quality and quantity for cultivation in the New Alluvial Zone of West Bengal.
Effects of pair migratory behavior on breeding phenology and success in a partially migratory shorebird population

Abstract In migratory systems, variation in individual phenology can arise through differences in individual migratory behaviors, and this may be particularly apparent in partial migrant systems, where migrant and resident individuals are present within the same population. Links between breeding phenology and migratory behavior or success are generally investigated at the individual level. However, for breeding phenology in particular, the migratory behaviors of each member of the pair may need to be considered simultaneously, as breeding phenology will likely be constrained by timing of the pair member that arrives last, and carryover effects on breeding success may vary depending on whether pair members share the same migratory behavior or not. We used tracking of marked individuals and monitoring of breeding success from a partially migrant population of Eurasian oystercatchers (Haematopus ostralegus) breeding in Iceland to test whether (a) breeding phenology varied with pair migratory behavior; (b) within‐pair consistency in timing of laying differed among pair migratory behaviors; and (c) reproductive performance varied with pair migratory behavior, timing of laying, and year. We found that annual variation in timing of laying differed among pair migratory behaviors, with resident pairs being more consistent than migrant and mixed pairs, and migrant/mixed pairs breeding earlier than residents in most years but later in one (unusually cold) year. Pairs that laid early were more likely to replace their clutch after nest loss, had higher productivity and higher fledging success, independent of pair migratory behavior. Our study suggests that the links between individual migratory behavior and reproductive success can vary over time and, to a much lesser extent, with mate migratory behavior and can be mediated by differences in laying dates. Understanding these cascading effects of pair phenology on breeding success is likely to be key to predicting the impact of changing environmental conditions on migratory species.
Decreases in Arterial Stiffness and Wave Reflection after Isometric Handgrip Training Are Associated with Improvements in Cognitive Function in Older Adults

This study aimed to investigate whether decreases in arterial stiffness and wave reflection after isometric handgrip (IHG) training improve cognitive function in older adults. Twenty-two older adults (mean age ± standard error: 75 ± 2 years) were randomly assigned to either a group that performed IHG training (IHG group, n = 11) or a sedentary control group (CON group, n = 11). The IHG exercise comprised four unilateral 2-minute isometric contractions at 30% of maximal voluntary contraction using a programmed handgrip dynamometer with 1-minute rest periods, performed 5 days per week for 8 weeks. Carotid pulse wave velocity (cPWV) and carotid augmentation index (cAIx) were measured, and the trail-making test (TMT) parts A (TMT-A) and B (TMT-B) were performed before (baseline) and after 8 weeks of training in both groups. After 8 weeks of training, cPWV, cAIx, TMT-A, and TMT-B were significantly reduced in the IHG group (p < 0.05). Significant positive correlations were found between the amount of change in cPWV and cAIx and that in TMT-A (p < 0.05 each). In addition, positive correlation trends were observed between the amount of change in cPWV and cAIx and that in TMT-B (p = 0.06, p = 0.05, respectively). The results of the present study suggest that IHG training-induced decreases in arterial stiffness and wave reflection are associated with improvements in cognitive function in older adults.
One year later: shifts and endurances in travel intentions of Bulgarian residents in the time of pandemic

The COVID-19 pandemic brought significant changes in all spheres of public life. Economically, as well as in terms of behavioural change, tourism has been one of the most affected sectors and nearly two years after the crisis began, the future is still unclear. This paper focuses on changes in tourist behaviour by tracking the shifts and persisting patterns within a one-year period. The study is based on two surveys conducted online in April 2020 and April 2021 and display the trends for a very specific and understudied context – a European country characterized by general distrust to the severity of the virus as well as towards imposed measures against the disease distribution at both national and international levels. Our findings question the wide-spread assumption that health-related concerns are the primary factor affecting tourist behaviour in the pandemic and identify travel restrictions and income as having major significance. Another important observation is the lack of significant changes within the study period, which examines two different situations: the onset of the pandemic that brought a great shock at all levels and a year later, when both objective circumstances and subjective perceptions were not expected to be the same.
Unravelling Potential Health-Beneficial Properties of Corema album Phenolic Compounds: A Systematic Review

Corema (C.) album belongs to the family Ericaceae and can be found in the Iberian Peninsula, especially on the coastal areas facing the Atlantic coast. C. album berries have been used for centuries in traditional medicine. Recent studies have revealed that not only the berries but also the leaves have relevant antioxidant, antiproliferative, and anti-inflammatory properties, bringing this plant to the forefront of discussion. A systematic review of the literature was carried out to summarize the phenolic compounds and bioactive properties identified in C. album berries and leaves and to search for research gaps on this topic. The search was conducted in three electronic databases (PubMed, SCOPUS, and Web of Science) using PRISMA methodology. The inclusion criteria were the chemical compositions of the berries, leaves, or their extracts and their bioactive properties. The exclusion criteria were agronomic and archaeological research. The number of studies concerning phenolic compounds’ composition and the bioactive properties of C. album berries and leaves is still limited (11 articles). However, the variety of polyphenolic compounds identified make it possible to infer new insights into their putative mechanism of action towards the suppression of NF-kB transcription factor activation, the modulation of inflammatory mediators/enzymes, the induction of apoptosis, the modulation of mitogen activated protein kinase, cell cycle arrest, and the reduction of oxidative stress. These factors can be of major relevance concerning the future use of C. album as nutraceuticals, food supplements, or medicines. Nevertheless, more scientific evidence concerning C. album’s bioactivity is required.