Miracle-dz/UniFAR-FTUs huggingface dataset:
DB121208 1435..1442

Dietary proteins are believed to participate significantly in maintaining blood glucose levels, but their contribution to endogenous glucose production (EGP) remains unclear. We investigated this question using multiple stable isotopes. After overnight fasting, eight healthy volunteers received an intravenous infusion of [6,6-H2]-glucose. Two hours later, they ingested four eggs containing 23 g of intrinsically, uniformly, and doubly [N]-[C]– labeled proteins. Gas exchanges, expired CO2, blood, and urine were collected over the 8 h following egg ingestion. The cumulative amount of dietary amino acids (AAs) deaminated over this 8-h period was 18.1 6 3.5%, 17.5% of them being oxidized. The EGP remained stable for 6 h but fell thereafter, concomitantly with blood glucose levels. During the 8 h after egg ingestion, 50.4 6 7.7 g of glucose was produced, but only 3.9 6 0.7 g originated from dietary AA. Our results show that the total postprandial contribution of dietary AA to EGP was small in humans habituated to a diet medium-rich in proteins, even after an overnight fast and in the absence of carbohydrates from the meal. These findings question the respective roles of dietary proteins and endogenous sources in generating significant amounts of glucose in order to maintain blood glucose levels in healthy subjects. Diabetes 62:1435–1442, 2013
Eating Habits: The Role of Early Life Experiences and Intergenerational Transmission

This study explores the long-run effects of a temporary scarcity of a consumption good on individuals’ preferences towards that good when the shock is over. We focus on people that passed their childhood during World War II and exploit the temporary fall in meat availability that they experienced early in life. We combine hand collected historical data on the number of livestock at the regional level with microdata on eating habits and meat consumption. By exploiting cohort and regional variation in a difference-in-differences estimation, we show that individuals that as children were more exposed to meat scarcity tend to consume more meat during late adulthood. Consistently with medical studies on the side effects of meat overconsumption, we find that these individuals have also a higher probability of being overweight and suffer from cardiovascular disease. The effects are larger for women and persist intergenerationally as the adult children of mothers who have experienced meat scarcity also tend to over-consume meat. Our results point towards a behavioral channel from early-life shocks into adult health and eating habits that we illustrate through a theoretical model of reference dependence and taste formation. JEL classifications: D12, I10, N44
Treatment of Acute Otitis Externa : Comparison of Steroid Antibiotic Versus 10% Ichthammol Glycerine Pack

To compare outcome of treatment between steroid–antibiotic and 10% Ichthammol glycerine packs (IG packs) in acute otitis externa. A prospective study between steroid–antibiotic and 10% IG pack which was performed in department of ENT, civil hospital jawalamukhi and civil hospital nagrota bhagwan from July 2019 to may 2020 on 32 patients was conducted. Age group among studied patients ranged from 14 to 56 years, with mean of 36.7 years. Out of which 20 (62.5%) were females and 12 (38.5%) were males. Pain assessed by Numerical Rating Scale (NRS) and edema was assessed by dividing the external auditory canal in two quadrant giving score of 50% for each on the day of presentation and subsequent visits till tragal sign and edema subsided. Average number of visits in 10% IG pack group (n = 16) was 4.6 days (2–5 visits) while in steroid–antibiotic group (n = 16) it was 3.5 days (2–5 visits). There was statistically significant decrease in the number of visits in steroid group (P \ 0.05). Similarly, decrease in pain score in second visit was significant in steroid antibiotic group as compared to 10% IG pack whereas it was statistically highly significant on third visit (P = 0.001). Since the reduction of pain and edema is more in the steroid antibiotic group hence the total number of packing is significantly less in steroid–antibiotic group, so it could be recommended to use steroid–antibiotic pack for effective treatment of acute otitis externa. Index Terms Acute otitis externa · Numeric rating scale · Steroid–antibiotic pack · 10% Ichthammol glycerine pack
Effects of Plant-row Spacing on Yield and Radiation Utilization Efficiency in Super Hybrid Rice

Super hybrid rice has higher yield potential.However,little information is available on the effect of cultivation techniques on yield of super hybrid rice.The objective of this study was to determine the effects of plant-row spacing on yield and radiation interception in super hybrid rice.Field experiments were conducted in Changsha,Guidong and Yongzhou in Hunan province in 2006 and 2007.Three super hybrid rice cultivars were grown under three plant-row spacings: Square(SQ),Rectangle(RE) and Stripline(ST). Yield,yield components and shoot dry matters were determined at maturity.Growth analyses were conducted at key stages to tiller development.PAR value at canopy and basal(10 cm above water) were monitored.The results showed that the average yield of three super rice varieties under ST was 9 387 kg/hm2,2.4% higher than RE and 4.3%(p0.05) higher than SQ,result from higher grain filling rate.The radiation interception of whole plant populations were almost the same among three plant-row spacings,while the leaves at the middle or at the bottom received more radiation under ST and RE than that under SQ.
Role Of Corporate Governance On SOE'S Financial Performance With Moderating Role Of Government Intervention

This study fills the research gap by examining the moderating role of government intervention between corporate governance, and the financial performance of State-Owned Enterprises (SOE’s). The data were collected from the top management of 202 SOEs of Pakistan. The study analyzed the data using structural equation model (SEM) and specifically the partial least square based structural equation modeling. Two-stage analysis approach was used to estimate the research model: the measurement model and the structural model. The results show that audit committee meeting, independent directors, management board size, and management board meetings have significant impact on SOEs' financial performance. Importantly, the results show no moderating role of government interventions between the proposed relationships of the study. This study is expected to contribute in threefold: increase the literature regarding the corporate governance and financial performance, examine the moderating role of government intervention between the corporate governance and financial performance of SOE’s, assists the regulatory authorities to establish and revise the corporate governance practice standards tailored to the unique context.
Research_9782343 1..10

Antiferroelectrics have attracted increasing research interests in recent years due to both their great potential in energy storage applications and intriguing structural characteristics. However, the links between the electrical properties and structural characteristics of distorted perovskite antiferroelectrics are yet to be fully deciphered. Here, we adopt local-structure methods to elucidate the nanoscale atomic structure of AgNbO3-based antiferroelectrics and their structural evolution upon La doping. The local structural features including interatomic distance distributions and atomic displacements have been analyzed using neutron small-box pair distribution function (PDF) refinement in conjunction with large-box Reverse Monte Carlo modelling. Our results highlight the correlation of cation displacements in AgNbO3 and its disruption by the incorporation of La, apparently in corroboration with the observed anomalous dielectric properties. Spatial ordering of cation vacancies is observed in La-doped AgNbO3 samples, which coordinates with oxygen octahedral tilting to relieve lattice strain. These results provide renewed insights into the atomic structure and antiferroelectric phase instabilities of AgNbO3 and relevant perovskite materials, further lending versatile opportunities for enhancing their functionalities.
CMAR_A_283199 843..850

Lorlatinib is an oral third-generation inhibitor of anaplastic lymphoma kinase (ALK) with activity in advanced ALKpositive non-small cell lung cancer (NSCLC) in both the first and subsequent line setting. Superior systemic and intracranial efficacy of lorlatinib over crizotinib, a first-generation ALK tyrosine kinase inhibitor (TKI), in treatment-naïve patients with advanced ALKpositive NSCLC was demonstrated by the phase 3 CROWN trial. Lorlatinib retains anti-tumor effect against single and some compound ALK resistance mutations after disease progression on firstand second-generation ALK TKIs. Currently, alectinib, brigatinib, ceritinib, crizotinib and lorlatinib are approved for treatment of advanced ALK-positive NSCLC. However, no head-tohead studies have directly compared lorlatinib to second-generation ALK inhibitors. Herein, we aim to provide an overview of the efficacy and safety of lorlatinib and discuss where lorlatinib stands in the therapeutic approach to advanced ALK-positive NSCLC.
Blended Teaching and the Changing Role of the Tutor – the need for a review of teacher professional development

[About the book] The Cambridge Guide to Blended Learning for Language Teaching makes the case that it is pedagogy, rather than technology, that should underpin the design of blended learning programmes. The book is organised into five sections: Connecting Theories and Blended Learning; Implications for Teaching; Rethinking Learner Interaction; Case Studies; The Future of Blended Learning. With its research-informed and practitioner-focused approach, this book is ideal for language teachers and language centre managers looking to broaden their understanding of pedagogy and blended learning. It will also be of interest to anyone working on blended learning course design or delivering teacher training courses.
Two novel variants in SCARF2 gene underlie van den Ende‐Gupta syndrome

Van den Ende–Gupta syndrome (VDEGS) (MIM#600920) is characterized by skeletal and craniofacial abnormalities that include prominent ears, downslanting palpebral fissures, blepharophimosis, hypoplastic maxilla with or without a cleft palate, a narrow and convex nasal bridge and an everted lower lip, camptodactyly and arachnodactyly. Intelligence is normal. Recent studies have reported that patients with VDEGS have pathogenic variants in the SCARF2 gene on chromosome 22q11.21. Here, we report two Turkish patients with two novel variants [c. 2291_2292insC (p.Ser765LeufsTer6) and c.488G>A (p.Cys63Tyr)] in the SCARF2 gene. In silico analysis predicted that both of these novel variants were pathogenic. To the best of our knowledge, this is the first case report of this syndrome in Turkey.
Relationships between highly skilled golfers' clubhead velocity and kinetic variables during a countermovement jump.

Previous research has sought to establish the relationship countermovement jump (CMJ) performance has with clubhead velocity (CHV). However, these investigations either assessed lower skilled golfers, or utilised field-based protocols, which are unable to assess a number of biomechanical variables. Fifty highly skilled golfers performed CMJs on Kistler force platforms in laboratory conditions. The CMJ variables included positive impulse, net impulse, average power, peak power, peak force, force at zero velocity and jump height. Clubhead velocity was measured using a TrackMan 3e launch monitor at a driving range. A Pearsons correlation was employed to measure the strength and direction of the relationships between CHV and CMJ derived performance variables. Results indicated strong positive relationships (all p's <0.001) between CHV and positive impulse (r = 0.695), net impulse (r = 0.689), average power (r = 0.645), peak power (r = 0.656), peak force (r = 0.517) and force at zero velocity (r = 0.528) with no significant relationship with jump height. However, if investigators only have access to field-based protocols, it is recommended that they measure jump height and utilise inverse dynamics to calculate take-off velocity. By multiplying take-off velocity by mass, this allows the attainment of net impulse.
A human kinase yeast array for the identification of kinases modulating phosphorylation‐dependent protein–protein interactions

Protein kinases play an important role in cellular signaling pathways and their dysregulation leads to multiple diseases, making kinases prime drug targets. While more than 500 human protein kinases are known to collectively mediate phosphorylation of over 290,000 S/T/Y sites, the activities have been characterized only for a minor, intensively studied subset. To systematically address this discrepancy, we developed a human kinase array in Saccharomyces cerevisiae as a simple readout tool to systematically assess kinase activities. For this array, we expressed 266 human kinases in four different S. cerevisiae strains and profiled ectopic growth as a proxy for kinase activity across 33 conditions. More than half of the kinases showed an activity‐dependent phenotype across many conditions and in more than one strain. We then employed the kinase array to identify the kinase(s) that can modulate protein–protein interactions (PPIs). Two characterized, phosphorylation‐dependent PPIs with unknown kinase–substrate relationships were analyzed in a phospho‐yeast two‐hybrid assay. CK2α1 and SGK2 kinases can abrogate the interaction between the spliceosomal proteins AAR2 and PRPF8, and NEK6 kinase was found to mediate the estrogen receptor (ERα) interaction with 14‐3‐3 proteins. The human kinase yeast array can thus be used for a variety of kinase activity‐dependent readouts.
Association of smoking, lung function and COPD in COVID‐19 risk: a two‐step Mendelian randomization study

Abstract Background and Aims Smoking increases the risk of severe COVID‐19, but whether lung function or chronic obstructive pulmonary disease (COPD) mediate the underlying associations is unclear. We conducted the largest Mendelian randomization study to date, to our knowledge, to address these questions. Design Mendelian randomization study using summary statistics from genome‐wide association studies (GWAS), FinnGen and UK Biobank. The main analysis was the inverse variance weighted method, and we included a range of sensitivity analyses to assess the robustness of the findings. Setting GWAS which included international consortia, FinnGen and UK Biobank. Participants The sample size ranged from 193 638 to 2 586 691. Measurements Genetic determinants of life‐time smoking index, lung function [e.g. forced expiratory volume in 1 sec (FEV1)], chronic obstructive pulmonary disease (COPD) and different severities of COID‐19. Results Smoking increased the risk of COVID‐19 compared with population controls for overall COVID‐19 [odds ratio (OR) = 1.19 per standard deviation (SD) of life‐time smoking index, 95% confidence interval (CI) = 1.11–1.27], hospitalized COVID‐19 (OR = 1.67, 95% CI = 1.42–1.97) or severe COVID‐19 (OR = 1.48, 95% CI = 1.10–1.98), with directionally consistent effects from sensitivity analyses. Lung function and COPD liability did not appear to mediate these associations. Conclusion There is genetic evidence that smoking probably increases the risk of severe COVID‐19 and possibly also milder forms of COVID‐19. Decreased lung function and increased risk of chronic obstructive pulmonary disease do not seem to mediate the effect of smoking on COVID‐19 risk.
Seven suggestions for successful SGLT2i use in glomerular disease - a standalone CKD therapy?

Purpose of review Recent advances in the world of glomerular diseases have largely focussed on remission induction with immune modulating therapy. It is well recognised that even with the best available treatments, patients with glomerular diseases may have an increased risk of progressive renal and cardiovascular disease. Recent findings The arrival of large trials looking at the benefits of sodium-glucose cotransporter 2 inhibitors (SGLT2i) in patients with chronic kidney disease (CKD) and diabetes or not has shifted the entire focus of current management and the shift needs to go further. This review summarises the background to these landmark trials and provides practical guidance for implementation of the results in a general nephrology clinic. In sub-group analyses of the Dapagliflozin and Prevention of Adverse Outcomes in Chronic Kidney Disease (DAPA-CKD) clinical trial, SGLT2i improved renal outcomes in patients with immunoglobulin A (IgA) nephropathy highlighting the potential for this drug class in glomerular disease. We also discuss where the gaps in evidence are and where future trials in glomerular diseases, be they primary or secondary, should be focussed. Summary The renal community has never before had evidence of this strength upon which to base recommendations for patients with CKD and we should be grasping it with both hands.
Comparative Study on Coconut Shell Aggregate with Conventional Concrete

Aggregates provide volume at low cost, comprising 66 percent to 78 percent of the concrete. Conventional coarse aggregate namely gravel and fine aggregate is sand in concrete will be used as control. While natural material is coconut shell as course aggregate will be investigate to replace the aggregate in concrete. In this studies, three different concrete mixes with different the combination of natural material content namely 0%, 10%, 20%, 30%. Three sample specimen will be prepared for each concrete mixes. The aim behind this is to use low cost material like coconut shell and thus taking close to the concept of low cost housing. All precaution is taken to maintain serviceability, strength and durability of the members. Thus it will be helpful for civil engineers and society to adopt this concept to fulfill the basic need of human that is housing.
Reoperations After Percutaneous Endoscopic Transforaminal Decompression for Treating Lumbar Spinal Stenosis: Incidence and Predictors

Study Design Retrospective cohort study. Objectives The main purpose of the present study was to report the incidence and identify predictors of reoperation in patients with lumbar spinal stenosis (LSS) treated with percutaneous endoscopic transforaminal decompression (PETD). Methods This study retrospectively reviewed consecutive patients with LSS who underwent PETD at our center between January 2016 and July 2020. The incidence of reoperations was calculated. We then designed a surgical period-matched case-control study to identify predictors among demographic data, clinical baseline data, and imaging parameters. Results This study identified 496 eligible patients. 33 (6.7%) patients underwent reoperation with a mean follow-up of 3 years, consisting 22 (4.4%) at the index level and 11 (2.2%) at the adjacent levels. There were significant differences in age and age-adjusted Charlson comorbidity index (AACCI) between the two groups, with younger age (P = .004) and lower AACCI (P = .019) in reoperation group. Age was identified as the sole independent predictor (P = .006). The duration of symptoms ≥12 months (P = .034) and the presence of heart problems (P = .012) were recognized as specific predictors among patients younger than 65 years. Conclusions In a mean follow-up of 3 years, the incidence of reoperation in LSS treated with PETD was 6.7%. A younger age was the independent predictor for reoperation. Younger patients with the duration of symptoms ≥12 months or without heart problems were more likely to undergo a second operation. Prospective randomized controlled trials are required to confirm these findings.
Line‐field confocal optical coherence tomography of basosquamous carcinoma: a case series with histopathological correlation

Basosquamous carcinoma (BSC) is a rare and potentially aggressive cutaneous neoplasm combining histopathological features of basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). Line‐field confocal optical coherence tomography (LC‐OCT) is a new, non‐invasive imaging technique featuring excellent resolution and penetration. To date, studies about the use of LC‐OCT in the BCC and SCC fields are available, but similar investigations are lacking in the BSC field.
Planners’ Perception on Factors that affects Plan Implementation in Iskandar Malaysia

Evaluating the plan implementation is essential not only to ensure the legitimacy of planning effort but also to increase stakeholder’s confidence in the plans that are constantly being formulated. Compared to other aspects of planning, the relationship between planning and implementation has been less studied mostly because of the complex processes and methodological difficulties. Nonetheless, most literatures recognized 19 criteria grouped under three key factors of plan implementation namely stakeholder characteristics, plan characteristics and implementation system characteristics. This study investigates the significant factors that contribute to a successful plan of implementation in Iskandar Malaysia (IM). The development of IM has been structured since 2006 by the Comprehensive Development Plan (CDP). The CDP is a developmental roadmap that provides a strategic framework of visions, principles, development strategies, goals and key directions for a region that is livable for its people. This study employed a semi-structured questionnaire which was administered to senior planning officers in five local authorities within IM. The survey was organized around two themes. The response to the utilization of implementation criteria was structured using Likert Scale. The Friedman test was used to indicate the level of the success of CDP implementation and to compare which factors most contribute to effective implementation. The study revealed that plan implementation is mainly driven by stakeholder’s characteristics, rather than the plan characteristic and implementation system characteristics.
The wash-in effect and its significance for mass casualty decontamination

ABSTRACT Decontamination of skin by washing may increase dermal absorption, a phenomenon known as the wash-in effect. The wash-in effect is frequently discussed in studies investigating casualty decontamination where potentially life-saving interventions may enhance the dermal penetration of toxic chemicals, leading to an increase in incidence of morbidity and rates of mortality. However, the wash-in effect is seldom investigated within the context of mass casualty decontamination and real-life consequences are therefore poorly understood. This paper reviews the existing literature on the wash-in effect to highlight the proposed mechanisms for enhanced absorption and evaluate the wash-in effect within the context of mass casualty chemical decontamination.