Miracle-dz/UniFAR-FTUs huggingface dataset:
OPTH_A_254705 1581..1589

Claudia Palacio-Pastrana 1 Eduardo ChávezMondragón 2 Abraham Soto-Gómez 3 Rubén Suárez-Velasco Miguel Montes-Salcedo Lourdes Fernández de Ortega Linda Nasser-Nasser 7 Leopoldo Baiza-Durán Oscar Olvera-Montaño 8 Patricia Muñoz-Villegas 8 1Fundación Hospital Nuestra Señora de la Luz, IAP, CDMX, Mexico; 2Fundación de Asistencia Privada Conde de Valenciana, IAP, CDMX, Mexico; 3Catarata y Glaucoma de Occidente SA de CV, Guadalajara, Jalisco, Mexico; 4Private Office, Guadalajara, Jalisco, Mexico; 5Aris Vision Institute, Guadalajara, Jalisco, Mexico; 6Asociación Para Evitar la Ceguera en México, IAP, CDMX, Mexico; 7Visión Cirugía Ambulatoria, Monterrey, Nuevo Leon, Mexico; 8Medical Affairs, Laboratorios Sophia, SA de CV, Zapopan, Jalisco, Mexico Background: The purpose of this study was to compare the efficacy and safety of difluprednate 0.05% (PRO-145) versus prednisolone acetate 1% (Prednefrin SF), for management of postoperative inflammation and pain, after cataract surgery. Methods: This was a Phase III, multicenter, prospective, double-blind, clinical trial. Intentto-treat population included 178 post-phacoemulsification patients that were assigned to receive either PRO-145, or prednisolone. One day after unilateral eye surgery, patients instilled a drop 4 times a day for 14 days (then tapering the dose downward for 14 days). The primary efficacy endpoints were anterior chamber (AC) cell grade and flare. Other parameters measured included: retinal central thickness (measured via OCT), conjunctival hyperemia, edema, pain and photophobia. Tolerability and safety were assessed through burning, itching, foreign body sensation, visual acuity (VA), intraocular pressure (IOP) and incidence of adverse events (AE). Results: A total of 171 subjects were randomized (1:1) and completed the study. Compared to day 1, there was a significant improvement in the AC cell count and flare in both groups by the final visit (80.2% vs 88.4%, p=1.000). Conjunctival hyperemia improved in a similar fashion (81.2% vs 79%, p=0.234) in both PRO-145 and prednisolone groups, without differences between them. This was also observed for edema (82.4% vs 82.5%, p=0.246), pain (15.3% vs 7%, p=0.497) and photophobia (16.4% vs 15.1%, p=0.246), respectively. There was no significant difference between treatments for any tolerability parameter studied. Finally, at the 4-week postoperative visit, there were no significant differences between treatments for VA, IOP and AE results (p-values; 0.095, 0.053 and 0.099, respectively). Conclusion: The results of this study suggest that PRO-145 is as effective and safe as prednisolone acetate in treating postoperative inflammation and pain in patients undergoing phacoemulsification. The study was registered at ClinicalTrials.gov as NCT03693989.
Intensive aerosol properties of Boreal and regional biomass burning aerosol at Mt. Bachelor Observatory: Larger and BC-dominant particles transported from Siberian wildfires

We characterize the aerosol physical and optical properties of 13 transported biomass burning (BB) events. BB events included long-range influence from fires in Alaskan and Siberian Boreal Forests transported to MBO in the free troposphere (FT) over 8-14+ days and regional wildfires in Northern California and Southwestern Oregon transported to MBO in the boundary 15 layer (BL) over 10 h to 3 days. Intensive aerosol optical properties and normalized enhancement ratios for BB events were derived from measured aerosol light scattering coefficients (σ scat ), aerosol light absorbing coefficients (σ abs ), fine particulate matter (PM 1 ), and carbon monoxide (CO) measurements made from July to September 2019, with particle size distribution collected from August to September. The observations showed that the Siberian BB events had lower 20 scattering Ångström exponent (SAE), higher mass scattering efficiency (MSE; Δσ scat /ΔPM 1 ), and a bimodal aerosol size distribution with a higher geometric mean diameter ( D g ). We hypothesize that the larger particles and associated scattering properties were due to the transport of fine dust alongside smoke, in addition to contributions from condensation of secondary aerosol, coagulation of smaller particles, and aqueous phase processing during transport. Alaskan and Siberian Boreal 25 Forest BB plumes were transported long distances in the FT and characterized by lower absorption Ångström exponent (AAE) values indicative of black carbon (BC) dominance in the radiative budget. Significantly elevated AAE values were only observed for BB events with <1 day transport, which suggests strong production of brown carbon (BrC) in these plumes but limited radiative forcing impacts outside of the immediate region. X. Intensive aerosol optical properties mass scattering and mass absorption efficiencies (MSE and MAE) were calculated as the NERs of Δσ scat /Δ PM 1 and Δσ abs /Δ PM 1 , respectively, at 550 nm for σ scat and 528 nm for σ abs . Single scattering albedo ( ω ) was calculated as the RMA regression of scattering and total extinction (scattering + absorption). In all cases the enhancements are large
Intracellular carbonic anhydrases influence pH signaling Intracellular carbonic anhydrase activity sensitizes cancer cell pH-signaling to dynamic changes in CO 2 partial pressure

accelerates CO 2 /HCO 3  equilibration. Results: In cells with high CA i activity, fluctuations in pCO 2 , that can arise from intermittent blood flow, evoke substantial intracellular pH oscillations which modulate down-stream pathways (calcium, mTOR). Conclusions: CA i transduces the state of perfusion to intracellular signaling. Significance: Coupling between environment and cell behavior may influence cancer progression.
Probucol inhibits compensatory remodeling and promotes lumen loss associated with atherosclerosis in apolipoprotein E deficient mice

Probucol was withdrawn from the US market because it failed to inhibit atherosclerosis in human femoral arteries, yet the drug was shown subsequently to inhibit atherosclerosis in human carotid arteries and probucol monosuccinate ester is presently being tested in a phase III clinical trial as an antiatherosclerotic compound based on its anti-inflammatory properties. Inflammatory macrophages are implicated in arterial remodeling associated with atherosclerosis, and probucol inhibits experimental atherosclerosis in part by decreasing macrophages in lesions. However, the impact of probucol on remodeling is unknown, although such knowledge could help explain why the drug’s benefit on human atherosclerosis is controversial. We therefore examined the effect of probucol on remodeling of the common carotid artery in apolipoprotein E-deficient mice. We observed that during de novo atherosclerosis, plaque growth was fully compensated by expansive remodeling, such that lumen area was unaffected. Early lesions were composed almost entirely of macrophages, and their contribution to lesion area progressively decreased thereafter. Probucol significantly decreased plaque area, expression of vascular cell adhesion molecule-1 and proliferation of intimal cells, resulting in delayed macrophage accumulation in the vessel. Probucol also decreased the production and activity of matrix metalloproteinases-2 and -9, independent of the plasmin protease system, and this was associated with an inhibition of expansive remodeling, resulting in lumen loss. These studies show that probucol attenuates compensatory remodeling associated with de novo atherosclerosis, likely via its anti-inflammatory properties. Our findings suggest that lumen volume is not a suitable surrogate to assess the antiatherosclerotic activity of probucol and related drugs.
twin anemia polycythemia

Objective: Our aim was to evaluate the diagnostic accuracy of middle cerebral artery peak systolic velocity (MCA-PSV) Doppler measurements in twin anemia polycythemia sequence (TAPS). Methods: In a consecutive cohort of monochorionic twin pregnancies with TAPS between 2005 and 2013 in three European fetal therapy centers, the accuracy to predict anemia and polycythemia of MCA-PSV measured just prior to fetal hemoglobin (Hb) measurement by fetal or cord blood sampling was assessed using 2x2 tables. Results: A total of 116 measurements (74 in donors and 42 in recipients) from 43 TAPS cases could be used for analysis. MCA-PSV multiples of the mean (MoM) values correlated well with Hb levels (R = -0.86 P < 0.001). The sensitivity of the MCA-PSV > 1.5 MoM to predict severe anemia (Hb deficit >5 standard deviations (SD)) in TAPS donors was 94% (95%CI 85-98%), specificity 74% (95%CI 62-83%), positive predictive value 76% (95%CI 65-85%), negative predictive value 94% (95%CI 83-98%). The sensitivity of MCA-PSV < 1.0 MoM to predict polycythemia (Hb >5SD above the mean) in TAPS recipients was 97% (95%CI 87-99%), specificity is 96% (95%CI 89-99%), positive predictive value 93% (95%CI 81-97%), negative predictive value 99% (95%CI 81-97%). Conclusion: This retrospective study shows a high diagnostic accuracy of MCA-PSV measurements for abnormal Hb levels in TAPS.
Earnings Downside Risk and Earnings Management

This study examines the association between earnings downside risk and earnings management. By capturing expectation for downward patterns in future operating performance, earnings downside risk (EDR) contains information about each firm’s risk. Firms with high earnings downside risk are more likely to experience negative operating performance in the future and are more affected by downward macroeconomic states. Such characteristics provide link to earnings attributes and earnings management. As anticipated, firm’s earnings downside risk is positively associated with accrual-based earnings management. However, the association between EDR and real earnings management is more complex. The findings show both consistent and inconsistent results with prior studies. This paper contributes to the usefulness of accounting-based information to reliably speculate firms’ earnings management behaviors and exploration of disparate nature of different forms of earnings management.
Specific Capital, Firm Insurance, and the Dynamics of the PostgraduateWage Premium

Postgraduate degree holders experience lower cyclical wage variation than those with undergraduate degrees. Moreover, postgraduates have more specific human capital than undergraduates. Using an equilibrium search model with long-term contracts and imperfect monitoring of worker effort, this paper attributes the cyclicality of the postgraduate-undergraduate wage gap to the differences in specific capital. Imperfect monitoring creates a moral hazard problem that requires firms to pay efficiency wages. More specific capital leads to lower mobility, thereby alleviating the moral hazard and improving risk-sharing. Estimates reveal that specific capital explains the differences both in labour turnover and in wage cyclicality across education groups. ∗Department of Economics, University of Essex, CO4 3SQ, UK, email: ran.gu@essex.ac. uk and Institute for Fiscal Studies. I am grateful for the generous support of Richard Blundell, Jeremy Lise, and Fabien Postel-Vinay. I am also thankful for the invaluable advice of Arun Advani, Ben Etheridge, Carlos Carrillo-Tudela, Alex Clymo, Melvyn Coles, Søren Leth-Petersen, Attila Lindner, Costas Meghir, Andreas Müller, Imran Rasul, Jean-Marc Robin, Uta Schönberg, Eric Smith and seminar participants at Bristol, Essex, EIEF, Royal Holloway, IFS, and UCL for helpful comments and suggestions.
Quantitative Bestimmung von Kräften auf den Nukleus während der Zellmigration Quantitative evaluation of nucleus strains during confined cell migration

Cell migration in confined environments is a burning topic, since it is one of the main biological processes ruling embryo-genesis, cancer metastasis or an organism immune system. Based on a previously developed cell confined migration model and the observation of micro-channels experiments, we decided to focus on two main aspects during this thesis. First, the evidence that the nucleus was capable of breaking its lamina to pass through narrow sub-nuclear constrictions led us to reconsider the way it was defined: we decided to use two different rheological models for the lamina and the nucleoplasm. While the latter is modeled as a viscoelastic medium, the first is defined as a viscoelastoplastic medium. Indeed the introduction of plasticity in the lamina could account for its ability to break down. We tested this new model in a compression test and then implemented it in the previous confined migration model. During confined migration, we highlighted the rate-limiting role of the nucleus and the effect of plasticity on the model. Our confined migration model relied on an adhesion-based migration mode, while all the recent interest in cell migration through confined environments featured a compression-based migration mode in which the cell would not need to form any focal adhesions with the substrate. We thus decided to focus on improving our migration mode to describe this adhesion-free mode that mostly occurs during three-dimensional confined migration and is referred to as ’chimneying’, since it mimics the behaviour of a rock climber in a chimney. During chimneying, the cell rear contraction triggers an increase in internal hydrostatic pressure, which then leads to the nucleation of a bleb – a herniation of the cell membrane – at the leading edge. When the bleb expands and touches the surface in which the cell is confined, it ’pushes’ against it, creating a perpendicular force that acts as an anchor for the cell to move forward. The cycle repeats and the cell migrates. We developed a first simple and deterministic model in which the cell has frontal and rear blebs that cyclically expand and retract and that push on the walls of the micro-channel to migrate through it. In this model, we ensure the synchronization between adhesion forces and active strains. A second model kept the same motion cycle but introduced the notion of self-regulation. Indeed, the cell is given conditions, and depending on whether they are met or not, the cell governs the migration steps. Eventually, we began developing a model with a motion that more closely resembles how chimneying looks like in live cells, with the rear contraction governing the bleb expansion. The model presented here is still preliminary and will be improved in the future.
A RESEARCH TO ASSESS AND ESTIMATE THE WORLDWIDE EPIDEMIOLOGY OF PREDIABETES WITH CURRENT AND FUTURISTIC PERSPECTIVE

: An intermediate condition of hyperglycemia refers to prediabetes which reflects the level of glucose more than normal range; whereas, these levels are under the maximum limit of diabetes. It is a well-known metabolic state as the prediabetes individuals are more prone to the development of overtly formed diabetes state along with related complications and disorders. Awareness about prediabetes may help to identify early diagnosis, timely medical intervention and reducing the total increase in the patients of diabetes. Different organizations present different screening guidelines for diabetes which result in the different estimation of diabetes prevalence. In the presence of such variations, different estimates present an increase in the diabetes cases who were classified as prediabetes all over the world. The objective of this research is to analyze the prediabetes diagnostic/ screening criteria, the relation between prevalence and glycemic measures and discuss present practice and futuristic perspective on the global burden of prediabetes.
Energy Efficient Design of Massive MIMO Based on Closely Spaced Antennas: Mutual Coupling Effect

Massive Multiple Input Multiple Output MIMO technology is a promising candidate for the next generation of communication applications, which essentially group hundreds of transmitting antennas together at the base station and provides the higher energy and spectral efficiency. In this article, the transmitting antennas are assumed to be closely spaced at the base station, which in turn results into a mutual coupling effect between the antenna terminals. The optimal system parameters and the energy efficiency are computed by considering the mutual coupling effect between the antenna terminals. Mutual coupling effect is deeply investigated on the energy efficiency and the other optimal parameters. We propose the domain splitter algorithm for the optimization of energy efficiency and the computation of different optimal system parameters in this article. The computational complexity of the proposed domain splitter algorithm is not dependent on the number of transceiver chains, and the detailed comparison is presented between the proposed and the reference algorithms on the basis of the computational complexity, which shows the effectiveness of the proposed domain splitter algorithm.
Evaluation of Two Rotary Nickel-Titanium Systems for Gutta Percha Removal during Endodontic Retreatment

Aims: The purposes of this study were to evaluate the efficacy of two rotary systems (RaCe and ProTaper) compared with hand files, in the removal of gutta percha during retreatment. Retreatment time, amount of apically extruded debris, and procedural errors were also evaluated. Materials and Methods: Forty extracted mandibular premolars were instrumented to size 30 and obturated with lateral condensed gutta percha. Then teeth were randomly divided into four groups, 10 teeth each. Removal was performing with chloroform and one of the following techniques: (I) Hedstrom and K-files, (II) Hedstrom and hand ProTaper, (III) Rotary ProTaper, and (IV) RaCe. Retreatment times, apically extruded debris, and broken instrument were recorded. The root split longitudinally viewed under stereomicroscope at (10 X) photograph are taken, and then the area of remaining filling material and whole area of the canal were measured using SigmaScan software. Data were analyzed statistically using one way ANOVA and Tukey test. Results: The two rotary systems left significantly less remaining filling material, faster, and produce less amount of apically extruded debris compared to hand files. There was no significant difference between the two rotary systems, but there was significant difference between the two hand files regarding the amount of remaining filling materials. Only RaCe exhib-its no fracture instruments during retreatment. Conclusions: The two rotary systems were found to be effective and faster in removing gutta percha during endodontic retreatment. endodontic retreatment, gutta percha removal, rotary systems. Al-Sabawi NA. Evaluation of Two Rotary Nickel-Titanium Systems for Gutta Percha Removal during Endodontic Retreatment. Al–Rafidain Dent J . 2013; 13(1): 21-28.
ANALYTICAL PHYSICOCHEMICAL SURVEY OF THE RECENTLY EXCAVATED MURALS AT THE TOMB OF IWRAKHY/HATIA AT SAQQARA, EGYPT

Present work presents an analytical survey of the murals at the tomb of Iwrakhy/Hatia (1550 BC-1077 BC). The owner was a noble lived during the ruling era of king Ramses II (reigned 1279-1213 BC), discovered during the Cairo University excavation season of 2018 at Saqqara area. New evidence is produced for the use of lead ores abreast with hematite as a source of red pigments, moreover; as well as proof of the mixing process of goethite with orpiment to get a gold-like colour. Stones, mortars, plasters and pigments were investigated using the digital microscope and the scanning electron microscope, and X-ray diffraction, SEM-EDX, while the paint medium was examined using the FTIR and Raman spectroscopy. Mortars and rendering layers are composed of gypsum, the latter is the ideal arriccio for the tempera murals and for the dry Egyptian climate; crushed limestone and quartz were added to gypsum as fillers. The red pigment is hematite mixed with lead; this represents a new discovery in the new kingdom murals. Yellow pigment is goethite mixed with orpiment, a rare case of the ancient Egyptian trials for gaining the effect of gilding on the walls, trying to imitate the common tradition in painting coffins. Regarding the blue pigment it is Egyptian blue containing high amounts of wollastonite and atacamite, blue is turned into greenish due to the presence of halite, animal glue was used as a paint medium in the studied tomb.
Evaluation of role of cytology and its pitfall in cytodiagnosis of vaginal discharge

Aim and Objectives: The present study was carried out with an objective 1) To find out the causes of discharge per vaginum, 2) To know the incidence of various causes of vaginal discharge, 3) To evaluate the role of cytology and its pitfall in cytodiagnosis of vaginal discharge, and 4) It can act as a screening procedure for cervical malignancies. Methods: Total 150 cases of leucorrhoea were studied using pH determination, wet mount, KOH mount, amine test, Gram staining and papanicolaou staining methods, during a period of one year. Results: Using all above methods we were able to detect non-specific vaginitis [70 (46.66%)], trichomonas vaginitis [24 (16.00%)], senile vaginitis [10 (6.66%)], candida vaginitis [13 (8.66%)] and gonococcal vaginitis [1 (0.66%)] while 24 (16.0%) cases were without any specific pathology. We found 3 (2.00%) cases suggestive of cervical erosion and 5 (3.33%) cases suggestive of squamous malignancies as a cause of discharge per vaginum. Out of 70 cases of non-specific vaginitis, 50 were suggestive of bacterial vaginosis. Pap stained smears were found to be 96.28% sensitive and 96.77% specific in diagnosing bacterial vaginosis while in diagnosing vaginal mycosis it was 48.22% sensitive and 100% specific as compared to cultures. KOH mount was 93.75% sensitive with 100% specificity in comparison to cultures. Conclusion: In a low resource setting, primary clinical diagnosis based on simple microscopy, pH determination, wet and KOH mount, amine test, gram staining should be made prior to pap stained screening to reach appropriate diagnosis in patients of vaginal discharge.