Miracle-dz/UniFAR-FTUs huggingface dataset:
Clinical and Economic Evaluation of Salvianolate Injection for Coronary Heart Disease: A Retrospective Study Based on National Health Insurance Data in China

Objective The study aimed to conduct clinical and economic evaluation of salvianolate injection for patients with coronary heart disease (CHD) in comparison to Danhong injection and alprostadil injection. Method This was a retrospective study using National Health Insurance Data about inpatients diagnosed with CHD in China in 2015 who met the inclusion criteria. The recruited patients were divided into two samples: surgery and non-surgery. The exposed group received salvianolate injection, while the control group received either alprostadil injection or Danhong injection. The medical cost per hospitalization, hospitalization duration, and the rehospitalization rates were used as outcome indicators. Heterogeneity was processed according to disease stratification. Propensity score matching and multivariate analysis were used for statistical analysis to control potential confounding factors. Results The hospitalization duration of salvianolate injection group was significantly (P < 0.05) shorter than that of Danhong injection group in the non-surgery sample. The hospitalization duration of salvianolate injection group was significantly (P < 0.05) shorter than those of alprostadil injection group in both surgery and non-surgery samples. In the non-surgery sample, the medical cost per hospitalization of salvianolate injection group was significantly (P < 0.05) lower than that of alprostadil injection group. However, there were no statistical differences of rehospitalization rates in salvianolate injection group versus alprostadil injection group or salvianolate injection group versus Danhong injection group in both surgery and non-surgery samples. Conclusion Salvianolate injection showed advantages in reducing hospitalization duration for inpatients with CHD when comparing with alprostadil injection and Danhong injection. The results of this real-world study can help to inform clinical practice for CHD patients.
Natural Transformation in Deinococcus radiodurans: A Genetic Analysis Reveals the Major Roles of DprA, DdrB, RecA, RecF, and RecO Proteins

Horizontal gene transfer is a major driver of bacterial evolution and adaptation to environmental stresses, occurring notably via transformation of naturally competent organisms. The Deinococcus radiodurans bacterium, characterized by its extreme radioresistance, is also naturally competent. Here, we investigated the role of D. radiodurans players involved in different steps of natural transformation. First, we identified the factors (PilQ, PilD, type IV pilins, PilB, PilT, ComEC-ComEA, and ComF) involved in DNA uptake and DNA translocation across the external and cytoplasmic membranes and showed that the DNA-uptake machinery is similar to that described in the Gram negative bacterium Vibrio cholerae. Then, we studied the involvement of recombination and DNA repair proteins, RecA, RecF, RecO, DprA, and DdrB into the DNA processing steps of D. radiodurans transformation by plasmid and genomic DNA. The transformation frequency of the cells devoid of DprA, a highly conserved protein among competent species, strongly decreased but was not completely abolished whereas it was completely abolished in ΔdprA ΔrecF, ΔdprA ΔrecO, and ΔdprA ΔddrB double mutants. We propose that RecF and RecO, belonging to the recombination mediator complex, and DdrB, a specific deinococcal DNA binding protein, can replace a function played by DprA, or alternatively, act at a different step of recombination with DprA. We also demonstrated that a ΔdprA mutant is as resistant as wild type to various doses of γ-irradiation, suggesting that DprA, and potentially transformation, do not play a major role in D. radiodurans radioresistance.
Private Savings and Transition: Dynamic Panel Data Evidence from Accession Countries

After the collapse in the early transition years, saving rates in Eastern European EU-accession countries have recovered strongly. But is private saving in these countries now driven by the same forces as in the EU? A GMM estimator is applied to analyze the determinants of private saving in both country groups. The main results are: saving rates are rather persistent; income growth increases saving, whereas public saving crowds out private saving. There is evidence that in both country groups domestic saving and foreign capital operate at least partly as substitutes, which is an indicator for international financial integration. The long-run effects of income growth and public saving are larger in the EU-15 than in the EU-accession countries.
Characterizing the chaotic nature of ocean ventilation

Ventilation of the upper ocean plays an important role in climate variability on interannual to decadal timescales by influencing the exchange of heat and carbon dioxide between the atmosphere and ocean. The turbulent nature of ocean circulation, manifest in a vigorous mesoscale eddy field, means that pathways of ventilation, once thought to be quasi-laminar, are in fact highly chaotic. We characterise the chaotic nature of ventilation pathways according to a nondimensional ‘filamentation number', which estimates the reduction in filament width of a ventilated fluid parcel due to mesoscale strain. In the subtropical North Atlantic of an eddy-permitting ocean model, the filamentation number is large everywhere across three upper ocean density surfaces — implying highly chaotic ventilation pathways — and increases with depth. By mapping surface ocean properties onto these density surfaces, we directly resolve the highly filamented structure and confirm that the filamentation number captures its spatial variability. These results have implications for the spreading of atmospherically-derived tracers into the ocean interior.
NETWORK OSCILLATION

The way a network develops over time has implications for the advantage it provides. We find that oscillation between closure and brokerage enhances network advantage. By “network oscillation” we refer to a period of deep engagement in a group (closure), followed by a period of connecting across groups (brokerage), followed by deep engagement in a group, followed by brokering, and so on. For evidence, we distinguish four dimensions to network volatility (churn, variation, trend, and reversal), measure the dimensions with panel data on a population of bankers, then add the volatility measures to models predicting banker compensation from status and structural hole measures of network advantage. Network volatility is not associated with performance directly or
Stimulating Factors and Origins of Precursor Cells in Traumatic Heterotopic Ossification Around the Temporomandibular Joint in Mice

The contributing factors and the origins of precursor cells in traumatic heterotopic ossification around the temporomandibular joint (THO-TMJ), which causes obvious restriction of mouth opening and maxillofacial malformation, remain unclear. In this study, our findings demonstrated that injured chondrocytes in the condylar cartilage, but not osteoblasts in the injured subchondral bone, played definite roles in the development of THO-TMJ in mice. Injured condylar chondrocytes without articular disc reserves might secrete growth factors, such as IGF1 and TGFβ2, that stimulate precursor cells, such as endothelial cells and muscle-derived cells, to differentiate into chondrocytes or osteoblasts and induce THO-TMJ. Preserved articular discs can alleviate the pressure on the injured cartilage and inhibit the development of THO-TMJ by inhibiting the secretion of these growth factors from injured chondrocytes. However, the exact molecular relationships among trauma, the injured condylar cartilage, growth factors such as TGFβ2, and pressure need to be explored in detail in the future.
Traumatic Events and Substance Use Disorders in Adolescents

Objectives Adolescents with substance use disorders (SUD) frequently report traumatic events (TEs) and symptoms of post-traumatic stress disorder (PTSD). This study aimed to assess whether lifetime prevalence rates of TEs and PTSD are related to SUD severity in adolescent psychiatric patients. Methods We analyzed N = 114 self-reports of treatment-seeking German adolescents aged 12 to 18 years, who visited a specialized SUD outpatient unit. Standardized questionnaires were applied to assess SUD severity, the number of TEs and DSM-IV PTSD criteria. Results Patients fulfilling PTSD criteria (28% of the total sample) had a higher Drug Use Disorders Identification Test (DUDIT) score compared to non-PTSD patients with TEs (p <.001), and compared to adolescents without TEs or PTSD (p = .003). Additionally, SUD severity was positively associated with the number of TEs and the number of intrusion, hyperarousal, and avoidance symptoms (all r = .33 to.48, all p <.01). Discussion Adolescent patients with SUD reported 3-times higher rates of TEs, and a 5-time higher prevalence of PTSD following TEs, than the general adolescent population. Adolescent SUD patients with PTSD reported more severe substance use problems than patients without PTSD—regardless of previous TEs. Longitudinal studies are needed in order to investigate the temporal relationship between TEs, PTSD and SUD.
A Study on Congruency Effects and Numerical Distance in Fraction Comparison by Expert Undergraduate Students

School mathematics comprises a diversity of concepts whose cognitive complexity is still poorly understood, a chief example being fractions. These are typically taught in middle school, but many students fail to master them, and misconceptions frequently persist into adulthood. In this study, we investigate fraction comparison, a task that taps into both conceptual and procedural knowledge of fractions, by looking at performance of highly mathematically skilled young adults. Fifty-seven Chilean engineering undergraduate students answered a computerized fraction comparison task, while their answers and response times were recorded. Task items were selected according to a number of mathematically and/or cognitively relevant characteristics: (a) whether the fractions to be compared shared a common component, (b) the numerical distance between fractions, and (c) the applicability of two strategies to answer successfully: a congruency strategy (a fraction is larger if it has larger natural number components than another) and gap thinking (a fraction is larger if it is missing fewer pieces than another to complete the whole). In line with previous research, our data indicated that the congruency strategy is inadequate to describe participants’ performance, as congruent items turned out to be more difficult than incongruent ones when fractions had no common component. Although we hypothesized that this lower performance for congruent items would be explained by the use of gap thinking, this turned out not to be the case: evidence was insufficient to show that the applicability of the gap thinking strategy modulated either participants’ accuracy rates or response times (although individual-level data suggest that there is an effect for response times). When fractions shared a common component, instead, our data display a more complex pattern that expected: an advantage for congruent items is present in the first experimental block but fades as the experiment progresses. Numerical distance had an effect in fraction comparison that was statistically significant for items without common components only. Altogether, our results from experts’ reasoning reveal nuances in the fraction comparison task with respect to previous studies and contribute to future models of reasoning in this task.
On the Interaction between Minimum Wage Adoption and Fiscal Redistribution: A Theoretical and Empirical Investigation

We explain the public’s support for the minimum wage (MW) institution despite economists’ warnings that the MW is a “blunt instrument” for redistribution. To do so we build a model in which workers are heterogeneous in ability, and the government engages in redistribution through the public provision of private goods. We show that the MW institution is politically viable only when there is a limited degree of in-kind redistribution. To examine the empirical relevance of our hypothesis we investigate the relationship between the probability of adopting MW legislation and the size of primary government spending by employing a dataset of 38 -developing and developed- countries from 1960 to 2017. Probit model estimations yield support for our theoretical prediction that a decrease in government spending increases the likelihood of a country enacting MW legislation. This negative association remains highly robust under alternative empirical specifications and estimation techniques.
Effect of Short-Term Transcutaneous Vagus Nerve Stimulation (tVNS) on Brain Processing of Food Cues: An Electrophysiological Study

Background: The vagus nerve plays an important role in the regulation of food intake. Modulating vagal activity via electrical stimulation (VNS) in patients and animal studies caused changes in food intake, energy metabolism, and body weight. However, the moderating impact of cognitive processes on VNS effects on eating behavior has not been investigated so far. Hypothesis: We hypothesized that transcutaneous VNS (tVNS) affects food intake by altering cognitive functions relevant to the processing of food-related information. Methods: Using a repeated-measurement design, we applied tVNS and a sham stimulation for 2 h on two different days in normal-weight subjects. We recorded standard scalp EEG while subjects watched food and object pictures presented in an oddball task. We analyzed the event-related potentials (ERPs) P1, P2, N2, and LPP and also examined the amount of consumed food and eating duration in a free-choice test meal. Results: Significant differences between stimulations were observed for the P1, P2, and N2 amplitudes. However, we found no tVNS-dependent modulation of food intake nor a specific food-related stimulation effect on the ERPs. Further analyses revealed a negative relationship between P2 amplitude and food intake for the sham stimulation. Significant effects are additionally confirmed by Bayesian statistics. Conclusion: Our study demonstrates tVNS’ impact on visual processing. Since the effects were similar between food and object stimuli, a general effect on visual perceptual processing can be assumed. More detailed investigations of these effects and their relationship with food intake and metabolism seem reasonable for future studies.
Consistent Estimation of the Number of Dynamic Factors in a Large N and T Panel

Bai and Ng proposed a consistent estimator for the number of static factors in a large N and T approximate factor model. This article shows how the Bai–Ng estimator can be modified to consistently estimate the number of dynamic factors in a restricted dynamic factor model. The modification is straightforward: The standard Bai–Ng estimator is applied to residuals obtained by projecting the observed data onto lagged values of principal-components estimates of the static factors.
Employers With Metabolic Syndrome and Increased Depression/Anxiety Severity Profit Most From Structured Exercise Intervention for Work Ability and Quality of Life.

Background Major depressive disorder and anxiety disorders are associated with less productivity, earlier retirement, and more sick-days at the workplace. These associations also exist for patients with metabolic syndrome. For both, exercise is a generally recommended part of multimodal treatments. However, for individuals with metabolic syndrome, in which depression and anxiety is more prevalent and severe, evidence for the efficacy of exercise interventions is limited. Methods Company employees with diagnosed metabolic syndrome (n=314, age: 48 ± 8 yrs) were randomized to a 6-month exercise intervention (150 min per week) or wait-list control. Participants received individual recommendations for exercise activities by personal meetings, telephone, or via a smartphone app. Physical activities were supervised and adapted using activity monitor data transferred to a central database. Work ability (work ability index), depression severity and anxiety severity [hospital anxiety and depression scale (HADS)], and health-related quality of live [short form 36 (SF-36)] were assessed. Results We included 314 subjects from which 287 finished the intervention. Total work ability, depression- and anxiety severity, and the mental component score of the SF-36 improved after 6 months exercise compared to controls. After baseline stratification for normal (HADS scores 0–7) and increased depression- and anxiety scores (HADS scores 8–21) individuals with increased severity scores had similar age, body composition, blood lipids, and cardiorespiratory fitness compared to those with normal scores, but lower total work ability and component sum scores of health-related quality of life. After 6 months total work ability increased in the exercise group compared to controls with the magnitude of the observed increase being significantly greater for subjects with increased depression- and anxiety severity at baseline compared to those with normal severity scores. Conclusions A 6-month exercise intervention for company employees with metabolic syndrome showed strongest effects on self-perceived work ability in individuals with mild to severe depression- and anxiety severity. This suggests exercise programs offered to workers with metabolic syndrome not only reduces individual disease risk but may also reduce healthcare and employers costs arising from metabolic syndrome and mental disease conditions. Clinical Trial Registration ClinicalTrials.gov, identifier NCT03293264.
How Does Private Firm Innovation Affect Anti-Takeover Provisions in Corporate Charters? Evidence from Firms Going Public

Using data on anti-takeover provisions (ATPs) and top management characteristics hand-collected from IPO prospectuses, we analyze the effect of the pre-IPO innovativeness and the top management quality of private firms on the number and strength of ATPs in IPO firm charters. We test the “long-term value creation” hypothesis, predicting that more innovative private firms and those with higher top management quality will have more (and stronger) ATPs in their charters; and the “management entrenchment” hypothesis, predicting the opposite. Our results support the former hypothesis. We show causality using an IV analysis using the leniency of patent examiners as an instrument.
Support for Separatism in Ethnic Republics of the Russian Federation

Abstract This study examines popular support for separatism among Russians and non-Russian titular nationalities (titulars) in 10 ethnic republics of the Russian Federation: Karelia, Komi, Tatarstan, Bashkortostan, Udmurtia, Adygea, Dagestan, Kabardino-Balkaria, Sakha-Yakutia and Tuva. A survey was carried out in the urban regions of these republics in 1999 and 2000 in which 5,233 Russians and 4,703 titulars participated. We found that perceived negative inter-group relations significantly contribute to support for separatism among titulars, but reduce support for separatism by Russians. In contrast, indicators of prosperity of the republic and prior separatist elite-activism predict support for separatism among both titulars and Russians.
Consent and vulnerability : some intersections between child sexual abuse and the trafficking in persons for sexual exploitation *

From the rapprochement between some aspects of the definition and management of the child sexual abuse and trafficking in persons for purposes of sexual exploitation as social problems, the present article argues that consent and vulnerability are complementary and key concepts for understanding the contemporary regimes of legal regulation of sexuality and of the social and political sensibilities which guide the perception of violence. By analyzing the assumptions of the concept of consent and its interrelations with the idea of individual autonomy, as well as the power and the ambiguities of the notion of vulnerability, understood as a category capable to deconstruct the central value of consent in the new sexual order oriented by liberal ideas and ideologies, I seek to illuminate some ethical and political dilemmas in the process of definition of violence and in the construction/deconstruction of the idea of victimization.
Argument Structure in Nicaraguan Sign Language : The Emergence of Grammatical Devices

We have had the unprecedented opportunity to observe a young, new language as its grammatical structure emerges. Because the changes taking place in the language are being driven by the children who are learning it, our observations also provide insight into children's biases in learning and organizing linguistic information. The present study examines the emergence of syntactic and morphological devices for indicating argument structure; that is, how subjects and objects are linked to their respective verbs. These devices have recently changed, and are likely to continue to change, as the language develops and evolves.
Differences in Working Memory With Emotional Distraction Between Proficient and Non-proficient Bilinguals

The impact of bilingual education and bilingual experience on working memory has been an important and controversial issue in the field of psycholinguistics. Taking Chinese-English bilinguals as an example, this study aims to investigate the differences in emotional working memory between proficient and non-proficient bilinguals by using delayed matching-to-sample task paradigm and the more complex N-back task in emotional contexts. The results show that proficient bilinguals may have better performance on both of these two working memory tasks than non-proficient bilinguals, and the advantage effects can be more apparent under high memory load conditions. In addition, the negative emotion context could have a positive impact on complex N-back tasks. This study supports the notion that bilingual experience can promote the development of an individual’s cognitive ability and enable individuals to possess more advantages in working memory even in the presence of emotional contexts.
Performance Evaluation, Economic Value Added and Managerial Behaviour

For the past two decades many countries started transforming their economies from traditional protected ones to those of more liberalized, globalized and market driven. This period has also seen the economies becoming more knowledge oriented and Human Resources started assuming more prominence in the growth of the economies and businesses posing a greater challenge for companies to acquire and retain talented workforce (especially at the strategic & managerial levels). The knowledge economy also started witnessing the rapid rise of the agency problem- conflict of interest between managers and owners. So it is very essential to align the interests of the mangers and shareholders or at least reduce the difference between them. In this regard Economic Value Added has been seen as better alternative to the stock price and traditional performance measures. While successful EVA stories in the west are quite encouraging, Corporate India is slowly catching up the EVA adoption. Although not a panacea, EVA based compensation plans will drive managers employ a firm's assets more productively and EVA should help reduce the difference in the interests of the managers and shareholders, if not perfectly align them.