Miracle-dz/UniFAR-FTUs huggingface dataset:
Antibody Profiling and In Silico Functional Analysis of Differentially Reactive Antibody Signatures of Glioblastomas and Meningiomas

Studies on tumor-associated antigens in brain tumors are sparse. There is scope for enhancing our understanding of molecular pathology, in order to improve on existing forms, and discover new forms, of treatment, which could be particularly relevant to immuno-oncological strategies. To elucidate immunological differences, and to provide another level of biological information, we performed antibody profiling, based on a high-density protein array (containing 8173 human transcripts), using IgG isolated from the sera of n = 12 preoperative and n = 16 postoperative glioblastomas, n = 26 preoperative and n = 29 postoperative meningiomas, and n = 27 healthy, cancer-free controls. Differentially reactive antigens were compared to gene expression data from an alternate public GBM data set from OncoDB, and were analyzed using the Reactome pathway browser. Protein array analysis identified approximately 350–800 differentially reactive antigens, and revealed different antigen profiles in the glioblastomas and meningiomas, with approximately 20–30%-similar and 10–15%-similar antigens in preoperative and postoperative sera, respectively. Seroreactivity did not correlate with OncoDB-derived gene expression. Antigens in the preoperative glioblastoma sera were enriched for signaling pathways, such as signaling by Rho-GTPases, COPI-mediated anterograde transport and vesicle-mediated transport, while the infectious disease, SRP-dependent membrane targeting cotranslational proteins were enriched in the meningiomas. The pre-vs. postoperative seroreactivity in the glioblastomas was enriched for antigens, e.g., platelet degranulation and metabolism of lipid pathways; in the meningiomas, the antigens were enriched in infectious diseases, metabolism of amino acids and derivatives, and cell cycle. Antibody profiling in both tumor entities elucidated several hundred antigens and characteristic signaling pathways that may provide new insights into molecular pathology and may be of interest for the development of new treatment strategies.
Shifting perceptions of age in voice

A series of experiments have been carried out in order to identify the acoustical and perceptual correlates of the aging voice. The initial phase of the program was to identify those voice parameters which signal a person’s age; the second phase was to systematically shift these parameters in order to determine if a parallel change in perceived age would occur. This second study focused on temporal characteristics related to voice. In this instance, standard speech samples for 16 males aged 70–90 years were contrasted with those of 14 males aged 20–33 years. The features studied included the following: (1) sentence duration, (2) word duration, (3) diphthong duration, (4) consonant‐vowel ratios, (5) number of pauses and (6) pause duration. Significant differences were found for all relationships. Subsequently, a preliminary study was carried out where the voices were synthesized and the temporal parameters for the two groups shifted toward each other. The preliminary data suggest that such modifications lead especially to the idea that the voices of older individuals actually were those of younger men.
Spectral Evolution of Field Galaxies

For the purpose of analyzing the spectral evolution of stellar population, we derive spectral energy distributions of simple stellar population in different ages from GALAXEV. Then, from stellar populations spectra, physical parameters are obtained for observational spectra of galaxies in the wavelength range from 3200 Å to 9500 Å. We use spectral data of Coleman and Wu for plotting the spectra of four types of galaxies. These observational data are combined and averaged from different sources; also they are extrapolated to high redshifts. In addition, we plot 16 synthesized spectra by considering Salpeter Initial Mass Function (IMF), exponential and constant Star Formation Rate (SFR) and solar metallicity for all spectra. Comparing the observational spectra with stellar population spectra, we analyze the age distribution for elliptical, irregular and two types of spiral field galaxies and obtain age and time scale parameters for each.
Convergence of the random vortex method in two dimensions

A theoretical framework for analyzing the random vortex method is presented. It extends and modifies the analysis of the inviscid vortex method in a natural and unified manner. The rate of convergence of the random vortex method in two dimensions is obtained by analyzing the consistency error and justifying the stability estimate. The sampling error introduced by the random motions of finitely many vortices is the dominant component of the consistency error in terms of order. It is estimated by applying Bennett's inequality. MATHEMATICAL SCIENCES INSTITUTE, CORNELL UNIVERSITY, ITHACA, NEW YORK 14850 This content downloaded from 207.46. 13.156 on Sat, 10 Sep 2016 05:39:41 UTC All use subject to http://about.jstor. org/terms
The content of ten elements in pig feed and manure and its relationship with element concentration in earthworms on swine farms

Abstract The aim of this investigation is to determine the content of ten elements, Cr, Mn, Co, Ni, Fe, Zn, As, Cu, Se, and Cd, in pig feed, manure and earthworms (Lumbricus terrestris). Samples were collected during 2015 and 2017, on four pig farms in Serbia, and analyzed for elements by inductively coupled plasma mass spectrometry. According to the mean concentrations, the elements show the following trends: Fe > Mn > Zn > Cr > Ni > Cu > Cd > Se > As > Co in monocalcium phosphate, Zn > Mn > Fe > Cu > Co > Cr > Ni > Se > As > Cd in vitamin-mineral premixes, Fe > Zn > Mn > Cu > Ni > Cr > Se > Co > As > Cd in complete feed, and Fe > Zn > Mn > Cu > Ni > Cr > Co > Se > Cd > As in pig manure. The obtained results show that monocalcium phosphate and vitamin-mineral premixes are the main source of Mn, Zn, and Fe in complete feed mixtures. The Cd concentration in one sample of monocalcium phosphate exceeds the maximum permissible level. Only one out of six investigated complete feed mixtures was in accordance with the national and EU regulations. The presence of Fe, Zn, and Mn in earthworms reflects their concentration in pig manure, but this is not noticed for Cr, Cu, Se, As, Ni, Co, and Cd.
On orbits of algebraic groups and Lie groups

In this paper we will be concerned with orbits of a closed subgroup Z of an algebraic group (respectively Lie group) G on a homogeneous space X for G. More precisely, let D be a closed subgroup of G and let X denote the coset space G/D. Let S be a subgroup of G and let Z denote (GS)0 the identity component of GS, the centralizer of S in G. We consider the orbits of Z on XS, the set of fixed points of S on X. We also treat the more general situation in which S is an algebraic group (respectively Lie group) which acts on G by automorphisms and acts on X compatibly with the action of G; again we consider the orbits of (GS)0 on XS.
The H13CN/HC15N Abundance Ratio in Dense Cores: Possible Source-to-Source Variation of Isotope Abundances?

We have observed the H13CN (J = 1-0) and HC15N (J = 1-0) lines simultaneously toward three dense cores in the Taurus molecular cloud complex and have found a significant source-to-source variation of the column density ratio, N(H13CN)/N(HC15N). The lowest ratio of 2.6-3.1 is observed toward L1521E, while the highest ratio of 8-11 is observed toward L1498. We have also observed the 12C18O (J = 1-0, 2-1) and 13C18O (J = 1-0) lines, and the 12C/13C ratio has been derived to be 58.8 ± 3.7 and ≥117 toward L1521E and L1498, respectively. These results imply that a substantial isotope fractionation effect may exist in the formation processes of these molecules, or elemental abundances are not uniform among the observed sources. If the source-to-source variation of the (14N/15N)/(12C/13C) ratio in HCN and the 12C/13C ratio in CO originates from the elemental abundance variation, the 14N/15N ratio is calculated to be 151 ± 16 and ≥813 for L1521E and L1498, respectively. These ratios significantly deviate from the values obtained toward Galactic disk sources.
Caustics in cylindrical ducts

This paper determines the caustic structure of the acoustic field reflected from the end face of a circular cylindrical duct when the incident field from inside the duct is a spinning acoustic mode. The rays of the reflected field are piecewise linear helices, which begin at the circular rim of the end face of the duct as straight–line diffracted rays lying on one–quarter of a Keller cone of diffracted rays, and continue by multiple reflection of straight–line ray segments off the circular wall of the duct. The caustics of the reflected field, which are envelopes of the axisymmetric curved surfaces obtained by rotating the piecewise linear helices about the duct axis, are infinite in number and have cusps. The paper analyses the resulting longitudinal chain of infinitely many cusped caustics, and shows that, because each cusp is close to a smooth caustic of the same family of rays, the reflected field contains a hyperbolic umbilic singularity. In terms of the reflection numberN of a ray segment, the hyperbolic umbilic region near segmentN has length of orderN−1/3 and width of orderN−2/3. The paper also determines the orders, as powers ofN, of the length and width of a wall region and an ‘outer region’. The orders are used to construct asymptotic expansions for the positions of the caustics in all the regions. The expansions satisfy Van Dyke's matching rule, and the leading terms are shown to be numerically accurate as early as the first reflection. The results are promising for the application of Keller's geometrical theory of diffraction and Weinstein's exact Wiener–Hopf theory to the study of acoustic fields and resonant interactions in aeroengine ducts. The mathematical techniques used in the paper, reflection–number asymptotics and a method of dominant triple balances, apply also to multiple reflections of acoustic fields and of internal waves in shear layers and in ocean waveguides.
Variability of plankton production during the spring bloom in NW Iberia

: A coupled physical (Regional Ocean Modeling System, ROMS)−biogeochemical model (N 2 PZD 2 ) at a horizontal resolution of 3.5 km was implemented for N and NW Iberia, an area of high productivity associated with upwelling. The physical model has been the object of previous studies and has proven its capability to perform well in reproducing the main oceano-graphic features in the area (upwelling, river plumes, slope currents, fronts, filaments), which is fundamental to properly representing the variability and distribution of the biogeochemical variables. The biogeochemical model was set up to account for the main nutrient inputs in the area: upwelling and rivers. Upwelling input required proper characterization of the nutrient content variability of the Eastern North Atlantic Central Water, which was achieved by using a tempera-ture−nitrate relationship obtained from observations to impose nitrate at the open boundaries. The resulting biophysical model accurately reproduced the timing and interannual variability of the spring bloom compared with satellite chlorophyll (chl a) observations. A comparison with the Instituto Español de Oceanografía’s in situ spring-monitoring Pelacus cruises (which include plankton) revealed that the model was able to reproduce the variability at shorter scales (days) and demonstrated its ability to complement the observational data and reveal the variability in the area around the spring transition. In this respect, both the model and observations showed that productivity on this narrow shelf is affected by seasonal upwelling that results from the interplay of wind, river plumes and light intensity, all varying at interannual, seasonal and event scales.
Nonthermal Plasma Treatment Can Eliminate Sandblasting Procedure For Zirconia-Resin Cement Bonding.

PURPOSE To evaluate the effects of nonthermal atmospheric plasma (NTAP) treatment, alone or combined with sandblasting and/or primer application, on the bonding of zirconia ceramics to resin cement. Materıals and Methods: A total of 420 discs of Y-TZP (2 x 15 x 12 mm) were prepared and randomly divided into 10 groups according to surface treatment, as follows: Z (control), SB (sandblasting), Pr (primer), SBPr (sandblasting + primer), P (NTAP), SBP (sandblasting + NTAP), PrP (primer + NTAP), SBPrP (sandblasting + primer + NTAP), PPr (NTAP + primer), and SBPPr (sandblasting + NTAP + primer). After surface treatments, the surface roughness values were evaluated using a profilometer, and the contact angle measurements were performed using a goniometer. Surface characterizations of the groups were analyzed using scanning electron microscopy and x-ray photoelectron spectroscopy analyses. Shear bond strength tests were performed after adhesive cementation in 20 specimens per group, with half (n = 10) subjected to thermocycling (5,000 cycles, 5°C to 55°C). The failure mode was recorded by examining each specimen using a stereomicroscope. One-way and two-way ANOVA followed by Student-Newman-Keuls test (α = .05) were used to analyze the data statistically. RESULTS Untreated zirconia surfaces (without sandblasting) were found to have a higher wettability and oxygen ratio after NTAP treatment. The clinical application order of NTAP is an important factor, and the best combination for bonding quality was NTAP treatment followed by primer application on untreated zirconia (group PPr), rather than on a sandblasted surface. Conclusıon: NTAP application may be a promising surface treatment method for adhesive cementation of zirconia ceramics as an alternative to sandblasting. To achieve strong adhesion, NTAP should be applied before primer aplication.
Uniformization of attracting basins for exponential maps

Soit la famille exponentielle complexe Eλ(Z)=λ exp(Z). Il y a un ensemble ouvert de valeurs de λ dans le plan complexe pour lesquelles Eλ a un point fixe attractif unique; Ωλ est le bassin d'attraction pour ces valeurs. On considere l'uniformisation Φλ de Ωλ et on etudie la dynamique induite par Φλ sur le disque unite
Sexuality and Religious Ethics: Analysis in a Multicultural University Context

Sexuality is still perceived by some cultures as a taboo subject. Although there is now a more open attitude towards sexuality, the maintenance of virginity is one of the most concerning issues in some religions. The aim of this research is to investigate the sexual behavior of university students and analyze how culture and religion influence the beliefs and maintenance of virginity in women and men. A mixed methodology was used, involving 355 students in the quantitative design and 18 informants for the qualitative study who took part in two focus groups. The results indicate that religion and the degree of religious practice are predictor variables for the decision to have penetrative sex, with Muslim women and men giving more importance to the maintenance of a woman’s virginity. However, this hymen-centric view does not prevent other sexual practices, such as oral and/or anal sex, among young people who wish to maintain their virginity until marriage. Religious ethics continue to influence the sexual behavior of young people today. Therefore, nursing education must address these issues to improve the affective sexual health of the population.
Antihyperglycemic Effects of Annona cherimola Miller and the Flavonoid Rutin in Combination with Oral Antidiabetic Drugs on Streptozocin-Induced Diabetic Mice

Ethanolic extract obtained from Annona cherimola Miller (EEAc) and the flavonoid rutin (Rut) were evaluated in this study to determine their antihyperglycemic content, % HbA1c reduction, and antihyperlipidemic activities. Both treatments were evaluated separately and in combination with the oral antidiabetic drugs (OADs) acarbose (Aca), metformin (Met), glibenclamide (Gli), and canagliflozin (Cana) in acute and subchronic assays. The evaluation of the acute assay showed that EEAc and Rut administered separately significantly reduce hyperglycemia in a manner similar to OADs and help to reduce % HbA1c and hyperlipidemia in the subchronic assay. The combination of EEAc + Met showed the best activity by reducing the hyperglycemia content, % HbA1c, Chol, HDL-c, and LDL-c. Rutin in combination with OADs used in all treatments significantly reduced the hyperglycemia content that is reflected in the reduction in % HbA1c. In relation to the lipid profiles, all combinate treatments helped to avoid an increase in the measured parameters. The results show the importance of evaluating the activity of herbal remedies in combination with drugs to determine their activities and possible side effects. Moreover, the combination of rutin with antidiabetic drugs presented considerable activity, and this is the first step for the development of novel DM treatments.
A MODEL OF THE BRIGHTNESS OF MOONLIGHT

In this paper, measurements of the sky brightness from the 2800-m level of Mauna Kea are reported. In addition, a model is presented for predicting the moonlight as a function of the moon's phase, the zenith distance of the moon, the zenith distance of the sky position, the angular separation of the moon and sky position, and the local extinction coefficient. The model equations can be quickly calculated on a pocket calculator. A comparison of the model with lunar data and with some Russian solar data shows the accuracy of the predictions to range from 8 percent to 23 percent.
A Qualitative Study on Voices of South African Learner Nurses on Occupational Health and Safety during Clinical Learning: Pre-COVID-19 Pandemic

The demanding and complex training of learner nurses in clinical practices requires various occupational health and safety measures to curb occupational health hazards among learner nurses. This paper aimed to explore learner nurses’ experiences concerning occupational health and safety during clinical learning. A qualitative descriptive, contextual and exploratory design study was conducted. A total of 31 learner nurses were selected using purposive sampling. Data were collected by semi-structured interviews and analysed using Tesch’s open coding method. Two themes emerged from this study: “The experiences of learner nurses concerning their health and safety during clinical learning” and “The measures to be taken to promote occupational health and safety during clinical learning. ” Highlighting challenges and measures to mitigate occupational health hazards among learner nurses in the South African context, Limpopo province, would be beneficial. The findings can assist stakeholders in developing specific precautionary guidelines for learner nurses. Effective and innovative occupational health and safety training programmes for learner nurses can be developed despite constrained environmental resources.
Tricarboxylic Acid Metabolite Imbalance in Rats with Acute Thioacetamide-Induced Hepatic Encephalopathy Indicates Incomplete Recovery

Exposure to the toxin thioacetamide (TAA) causes acute hepatic encephalopathy (HE), changes in the functioning of systemic organs, and an imbalance in a number of energy metabolites. The deferred effects after acute HE development are poorly understood. The study considers the balance of the tricarboxylic acid (TCA) cycle metabolites in the blood plasma, liver, kidneys, and brain tissues of rats in the post-rehabilitation period. The samples of the control (n = 3) and TAA-induced groups of rats (n = 13) were collected six days after the administration of a single intraperitoneal TAA injection at doses of 200, 400, and 600 mg/kg. Despite the complete physiological recovery of rats by this date, a residual imbalance of metabolites in all the vital organs was noted. The results obtained showed a trend of stabilizing processes in the main organs of the animals and permit the use of these data both for prognostic purposes and the choice of potential therapeutic agents.
Is the lotus leaf superhydrophobic

Superhydrophobic surfaces have important technical applications ranging from self-cleaning window glasses, paints, and fabrics to low-friction surfaces. The archetype superhydrophobic surface is that of the lotus leaf. When rain falls on lotus leaves, water beads up with a contact angle in the superhydrophobic range of about 160°. The water drops promptly roll off the leaves collecting dirt along the way. This lotus effect has, in recent years, stimulated much research effort worldwide in the fabrication of surfaces with superhydrophobicity. But, is the lotus surface truly superhydrophobic? This work shows that the lotus leaves can be either hydrophobic or hydrophilic, depending on how the water gets on to their surfaces. This finding has significant ramifications on how to make and use superhydrophobic surfaces.
Multidrug-Resistant Bacteria in a COVID-19 Hospital in Zagreb

During November to December 2020, a high rate of COVID-19-associated pneumonia with bacterial superinfections due to multidrug-resistant (MDR) pathogens was recorded in a COVID-19 hospital in Zagreb. This study analyzed the causative agents of bacterial superinfections among patients with serious forms of COVID-19. In total, 118 patients were hospitalized in the intensive care unit (ICU) of the COVID-19 hospital. Forty-six out of 118 patients (39%) developed serious bacterial infection (VAP or BSI or both) during their stay in ICU. The total mortality rate was 83/118 (70%). The mortality rate due to bacterial infection or a combination of ARDS with bacterial superinfection was 33% (40/118). Six patients had MDR organisms and 34 had XDR (extensively drug-resistant). The dominant species was Acinetobacter baumannii with all isolates (34) being carbapenem-resistant (CRAB) and positive for carbapenem-hydrolyzing oxacillinases (CHDL). One Escherichia coli causing pneumonia harboured the blaCTX-M-15 gene. It appears that the dominant resistance determinants of causative agents depend on the local epidemiology in the particular COVID center. Acinetobacter baumannii seems to easily spread in overcrowded ICUs. Croatia belongs to the 15 countries in the world with the highest mortality rate among COVID-19 patients, which could be in part attributable to the high prevalence of bacterial infections in local ICUs.
Effect of Teriparatide on Bone Mineral Density and Bone Markers in Real-Life: Argentine Experience

Purpose To evaluate the effect of teriparatide (TPTD) on bone mineral density (BMD) and bone markers under clinical practice conditions. To assess whether the results in real-life match those published in clinical trials. Methods Cross-sectional study of postmenopausal women treated with TPTD for at least 12 months. Results 264 patients were included in the study. Main characteristics are as follows: age: 68.7 ± 10.2 years, previous fractures: 57.6%, and previously treated with antiresorptive (AR-prior): 79%. All bone turnover markers studied significantly increased after 6 months. CTX and BGP remained high up to 24 months, but total and bone alkaline phosphatase returned to basal values at month 18. There was a significant increase in lumbar spine (LS) BMD after 6 months (+6.2%), with a maximum peak at 24 months (+13%). Femoral neck (FN) and total hip (TH) BMD showed a significant increase later than LS (just at month 12), reaching a maximum peak at month 24 (FN + 7.9% and TH + 5.5%). A significant increase in LS BMD was found from month 6 to month 24 compared to basal in both AR-naïve, and AR-prior patients (+16.7% and +10.5%, respectively), without significant differences between the two groups. Comparable results were found in FN and TH BMD. Main conclusions. As reported in real-life clinical studies, treatment of osteoporotic postmenopausal women with TPTD induced a significant increase in bone turnover markers from month 6 onward and an increase in BMD from months 6–12 with continuous gain up to month 24. The real-life results of our study matched the results of randomized clinical trials. In addition, TPTD induced an increase in BMD, regardless of the previous use of AR.