Miracle-dz/UniFAR-FTUs huggingface dataset:
Separation of 44Sc from 44Ti in the Context of A Generator System for Radiopharmaceutical Purposes with the Example of [44Sc]Sc-PSMA-617 and [44Sc]Sc-PSMA-I&T Synthesis

Today, 44Sc is an attractive radionuclide for molecular imaging with PET. In this work, we evaluated a 44Ti/44Sc radionuclide generator based on TEVA resin as a source of 44Sc. The generator prototype (5 MBq) exhibits high 44Ti retention and stable yield of 44Sc (91 ± 6 %) in 1 mL of eluate (20 bed volumes, eluent—0.1 M oxalic acid/0.2 M HCl) during one year of monitoring (more than 120 elutions). The breakthrough of 44Ti did not exceed 1.5 × 10−5% (average value was 6.5 × 10−6%). Post-processing of the eluate for further use in radiopharmaceutical synthesis was proposed. The post-processing procedure using a combination of Presep® PolyChelate and TK221 resins made it possible to obtain 44Sc-radioconjugates with high labeling yield (≥95%) while using small precursor amounts (5 nmol). The proposed method takes no more than 15 min and provides ≥90% yield relative to the 44Sc activity eluted from the generator. The labeling efficiency was demonstrated on the example of [44Sc]Sc-PSMA-617 and [44Sc]Sc-PSMA-I&T synthesis. Some superiority of PSMA-I&T over PSMA-617 in terms of 44Sc labeling efficiency was demonstrated (likely due to presence of DOTAGA chelator in the precursor structure). It was also shown that microwave heating of the reaction mixture considerably shortened the reaction time and improved radiolabeling yield and reproducibility of [44Sc]Sc-PSMA-617 and [44Sc]Sc-PSMA-I&T synthesis.
Barriers and Enablers for the Integration of Industry 4.0 and Sustainability in Supply Chains of MSMEs

The integration of Industry 4.0 (I4.0) and sustainability in supply chains emerged as a relevant topic and, therefore, has attracted the interest of academics and practitioners. Many barriers challenge this integration, and enablers to overcome these barriers need to be understood. Micro, Small & Medium Enterprises (MSMEs) have many difficulties to overcome these barriers and successfully implement this integration. Moreover, solutions for larger enterprises do not necessarily fit MSMEs, which reinforces the need to investigate the topic further. Within this context, the goals of this paper are: (i) to identify the main barriers and enablers to integrate I4.0 and sustainability in supply chains of MSMEs and (ii) to analyze the influence among these barriers and enablers, identifying the most prominent ones. A convergent parallel multimethod approach is adopted, first embracing a scoping review to identify main barriers, enablers, and associated categories. Then, conducting a panel of experts with 25 specialists in two rounds to refine and classify the identified barriers and enablers towards the perspective of MSMEs. Finally, two focus group discussions are added using the fuzzy logic and DEMATEL methods to obtain the inter-relationship of barriers and enablers for MSMEs. Research findings reveal eight barriers, eight enablers, and their respective cause-effect relationship, which are expected to help MSMEs managers and decision-makers better understand and implement the integration between I4.0 and sustainability in their supply chains. Results are discussed in eleven research propositions and four propositions for practitioners and policymakers.
Occurrence of enterobacteriaceae in fresh camel meat with special reference to salmonellae

Eighty random samples of freshly slaughtered camel meat were collected from 4 different abattoirs namely (A) El-shohdaa, (B) El-Bagour, (C) Menouf and (D) Sadat (20 of each) located in Menofia governorate. and subjected to bacteriological examination . The obtained results declared that the mean Enterobacteriaceae counts in examined meat camel samples were recorded descendingly in different abattoirs as in B (9.77 × 10 3.44× 10 )then in D ( 7.86 × 10 4.91 × 10 ) then in A (7.50 × 10 4.08 × 10 ) then in C (1.40 × 10 6.54 × 10 ). Incidence and serotyping of E.coli isolated from the examined samples of camel meat from the different abattoirs were ( O19:H21, O44:H18 ,O86, O111:H4,O114:H4,O124,O127:H6,O121:H7,O171:H2) with ratio (5 ,0 ,5 ,0 ,5 ,5 , 0 , 0, 0, 0) , (10 , 0, 0, 5 ,0 ,5 ,5 ,5 ,0) , ( 5 ,10 ,0 ,0 ,5 ,5 ,0 ,0 ,0) and (5, 10, 0 ,0 ,5 ,5 ,0 ,0 ,0) in A , B, C and D abattoirs, respectively . Salmonellae isolated from the examined samples of camel meat from the different abattoirs were S.Enteritidis, Typhimurium, Virchow, Heidberg ,Kentucky and Infantis with ratio (5% ,10% ,0% .0%,5% ,5% ),(5% ,5% ,0% ,0% ,0% ,0%),(10% ,10% ,5% ,5% ,5% ,0%) and (5%,5%,0%,0%,5%,5%) in A , B,C and D abattoirs , respectively.
PERKEMBANGAN KURIKULUM PENDIDIKAN VOKASIONAL BERBASIS PADA KEBUTUHAN DUNIA INDUSTRI

Pendidikan dan Pelatihan Vokasional merupakan salah satu pendidikan yang sangat penting dalam meningkatkan keterampilan dan pengetahuan siswa. Sekolah Menengah Kejuruan sebagai salahsatu pendidikan vokasional berperan penting dalam menghasilkan lulusan yang berkualitas dan siap memasuki dunia kerja. Sekolah di Indonesia belum membentuk lulusan yang mempunyai soft skills danhard skills yang memiliki kecocokan atau kesesuaian dengan Dunia Usaha/Dunia Industri dan padaakhirnya lulusan ketika memasuki dunia kerja akan mengalami kesulitan beradaptasi denganperkembangan teknologi yang ada di industri. Artikel ini bertujuan untuk mendeskripsikan perkembangankurikulum pendidikan vokasional berbasis pada kebutuhan industri. Penelitian ini menggunakanpendekatan penelitian kualitatif dengan jenis penelitian desain penelitian deskriptif. Teknik pengumpulandata dengan telaah kepustakaan di mana dalam pembuatan artikel ini dikutip dari artikel yang telahdipublikasi pada jurnal atau prosiding ilmiah. Pelaksanaan kurikulum pendidikan vokasional saat inibelum sesuai pada kebutuhan Dunia Industri menurut Mendikbud: Muhadjir Effendy dan Kemnaker,sehingga terjadi ketidakcocokan atau ketidaksesuaian dengan kebutuhan Dunia Usaha dan Dunia Industri(DUDI) termasuk masyarakat.
Ellipse packing in 2D cell tessellation: A theoretical explanation for Lewis’s law and Aboav-Weaire’s law

Background: To date, the theoretical bases of Lewis’s law and Aboav-Weaire’s law are still unclear. Methods: Software R with package Conicfit was used to fit ellipses based on geometric parameters of polygonal cells of red alga Pyropia haitanensis. Results: The average form deviation of vertexes from the fitted ellipse was 0 \(\pm\) 3.1 % (8,291 vertices in 1375 cells were examined). The area of polygonal cell was 0.9 \(\pm\)0.1 times of the area of the ellipse’s maximal inscribed polygon (EMIP). These results indicated that the polygonal cells could be considered as ellipse’s inscribed polygons (EIPs) and tended to form EMIPs. This phenomenon was named as ellipse packing. Based on the numbers of cell edges, cell area and geometries of fitted ellipses, we derived and verified the new relations of Lewis’s law and Aboav-Weaire’s law. Lewis’s law for a n-edged cell: \[cell\ area=0.5nab\sin\left(\frac{2\pi}{n}\right)\left(1-\frac{3}{n^2}\right)\] Aboav-Weaire’s law: \[average\ side\ number\ of\ neighboring\ cells=6+\frac{6-n}{n}\times \left(\frac{a}{b}+\frac{3}{n^2}\right)\] where \(a\) and \(b\) are the semi-major axis and the semi-minor axis of fitted ellipse, respectively. Conclusions: Ellipse packing is a short-range order which places restrictions on the direction of cell division and the turning angles of cell edges. The ellipse packing requires allometric growth of cell edges. Lewis’s law describes the effect of deformation from EMIP to EIP on area. Aboav-Weaire’s law mainly reflects the effect of deformation from circle to ellipse on number of neighboring cells, and the deformation from EMIP to EIP has only a minor effect. The results of this study could help to simulate the dynamics of cell topology during growth.
Exploring The Influences on Cyber Education in a Bilingual Higher Institution

This paper presents the research study which explores the variables influencing the learning effectiveness of the students taking an online introductory information technology course in cyber education in a bilingual higher education institution in Hong Kong. These variables are: (1) student's English proficiency, (2) instructor's guidance in an online discussion forum and (3) peer students' collaboration in an online discussion forum. Correlation analysis was adopted to identify whether any of these variables could be potential factors on the students 'learning performance while multiple regression analysis was performed to explore the combined effect of these variables on the students' learning performance. Validity and reliability of this research study are highlighted in this paper. Finally, the research findings are discussed.
Willingness to donate eyes among outpatients attending Muhimbili National Hospital

Background: Willingness to donate eyes and other organs in general is still unsatisfactory worldwide, specifically in low income countries including Sub-Saharan Africa where the awareness about eye and other organs donation is still low. Factors like religion may also affect people’s decision making in terms of organ donation. Therefore, it is difficult to have enough tissues for transplant and sustainable local eye banks. The aim of the study was to assess willingness to donate eyes among outpatients attending Muhimbili National Hospital, Tanzania. Methodology: A cross sectional hospital based study with quantitative and qualitative approaches was done from July to December 2017. Systematic random sampling and purposive sampling techniques were used for quantitative and qualitative parts respectively. Results: A total of 434 participants were interviewed, 58.06% were female. Only 32.5% of all respondents, were aware that eyes can be donated, while 47.9% were willing to donate their eyes. The main reason for willingness was to help a blind person (64.25%), while the main reason for unwillingness was need of more information about eye donation (31.7%), followed by religious reasons (22.0%). Willingness to donate eyes was associated with prior awareness (p=0.0001), religion (p=0.010) and sex (p=0.049). Important themes emerged from the Focus Group Discussion (FGD) were: Helping needy people, religion, death and respect of body. Conclusion: Willingness to donate eyes was seen in nearly a half of the participants though awareness was low. Most of the participants had positive perception about eye donation services. Negative perception was associated with lack of information, religious beliefs and fear. Therefore, community education is important to raise awareness and willingness to donate eyes.
Effects of Metformin, Buformin, and Phenformin on the Post-Initiation Stage of Chemically Induced Mammary Carcinogenesis in the Rat

Metformin is a widely prescribed drug for the treatment of type II diabetes. Although epidemiologic data have provided a strong rationale for investigating the potential of this biguanide for use in cancer prevention and control, uncertainty exists whether metformin should be expected to have an impact in nondiabetic patients. Furthermore, little attention has been given to the possibility that other biguanides may have anticancer activity. In this study, the effects of clinically relevant doses of metformin (9.3 mmol/kg diet), buformin (7.6 mmol/kg diet), and phenformin (5.0 mmol/kg diet) were compared with rats fed control diet (AIN93-G) during the post-initiation stage of 1-methyl-1-nitrosourea-induced (50 mg/kg body weight) mammary carcinogenesis (n = 30/group). Plasma, liver, skeletal muscle, visceral fat, mammary gland, and mammary carcinoma concentrations of the biguanides were determined. In comparison with the control group, buformin decreased cancer incidence, multiplicity, and burden, whereas metformin and phenformin had no statistically significant effect on the carcinogenic process relative to the control group. Buformin did not alter fasting plasma glucose or insulin. Within mammary carcinomas, evidence was obtained that buformin treatment perturbed signaling pathways related to energy sensing. However, further investigation is needed to determine the relative contributions of host systemic and cell autonomous mechanisms to the anticancer activity of biguanides such as buformin. Cancer Prev Res; 8(6); 518–27. ©2015 AACR.
Quantificação de fósforo por Mehlich 1, Mehlich 3 e Resina Trocadora de Ânions em solos com diferentes teores de argila

RESUMO Os extratores de fósforo (P) Mehlich 1 (M-1), Mehlich 3 (M-3) e Resina Trocadora de Ânions (RTA) apresentam sensibilidade ao conteúdo de argila do solo. Ainda, o uso de equações para conversão do P disponível extraído por M-3 em valores equivalentes de M-1 pode não ser adequado para um conjunto de solos contrastantes. O objetivo do trabalho é avaliar a influência do conteúdo de argila na extração de P por M-1, M-3 e RTA, bem como avaliar a efetividade de utilização de equações para conversão dos teores por M-3 em valores equivalentes de M-1. Foram selecionadas 301 amostras de solo no laboratório de rotina do CAV/UDESC, distribuídos em quatro classes de argila: 0-20, 21-40, 41-60 e > 60% de argila. As amostras foram preparadas e foi extraído o P disponível por M-1, M-3 e RTA. Os extratores M-3 e RTA extraíram quantidades de P 12 e 11% superiores ao M-1, respectivamente. M-1 extraiu menos P que M-3 e RTA em solos de textura arenosa e extraiu mais P que os demais extratores em solos de textura argilosa. A equação sugerida pela CQFS - RS/SC (2016) para conversão dos teores de M-3 para equivalentes em M-1 subestimou os valores de P em até 24%. Com isso, alternativamente, se propõe a utilização da equação P-M1eq (mg dm-3) = (P-M3 / (1,38-0,01*Arg)). Os métodos avaliados apresentam sensibilidade ao teor de argila do solo, devendo ser realizada a classificação da disponibilidade P por faixas de textura.
Quantitative N-Glycan Profiling of Therapeutic Monoclonal Antibodies Performed by Middle-Up Level HILIC-HRMS Analysis

The identification and accurate quantitation of the various glycoforms contained in therapeutic monoclonal antibodies (mAbs) is one of the main analytical needs in the biopharmaceutical industry, and glycosylation represents a crucial critical quality attribute (CQA) that needs to be addressed. Currently, the reference method for performing such identification/quantitation consists of the release of the N-glycan moieties from the mAb, their labelling with a specific dye (e.g., 2-AB or RFMS) and their analysis by HILIC-FLD or HILIC-MS. In this contribution, the potential of a new cost- and time-effective analytical approach performed at the protein subunit level (middle-up) was investigated for quantitative purposes and compared with the reference methods. The robustness of the approach was first demonstrated by performing the relative quantification of the glycoforms related to a well characterized mAb, namely adalimumab. Then, the workflow was applied to various glyco-engineered mAb products (i.e., obinutuzumab, benralizumab and atezolizumab). Finally, the glycosylation pattern of infliximab (Remicade®) was assessed and compared to two of its commercially available biosimilars (Remsima® and Inflectra®). The middle-up analysis proved to provide accurate quantitation results and has the added potential to be used as multi-attribute monitoring method.
Epigenetic Clock and Circadian Rhythms in Stem Cell Aging and Rejuvenation

This review summarizes the current understanding of the interaction between circadian rhythms of gene expression and epigenetic clocks characterized by the specific profile of DNA methylation in CpG-islands which mirror the senescence of all somatic cells and stem cells in particular. Basic mechanisms of regulation for circadian genes CLOCK-BMAL1 as well as downstream clock-controlled genes (ССG) are also discussed here. It has been shown that circadian rhythms operate by the finely tuned regulation of transcription and rely on various epigenetic mechanisms including the activation of enhancers/suppressors, acetylation/deacetylation of histones and other proteins as well as DNA methylation. Overall, up to 20% of all genes expressed by the cell are subject to expression oscillations associated with circadian rhythms. Additionally included in the review is a brief list of genes involved in the regulation of circadian rhythms, along with genes important for cell aging, and oncogenesis. Eliminating some of them (for example, Sirt1) accelerates the aging process, while the overexpression of Sirt1, on the contrary, protects against age-related changes. Circadian regulators control a number of genes that activate the cell cycle (Wee1, c-Myc, p20, p21, and Cyclin D1) and regulate histone modification and DNA methylation. Approaches for determining the epigenetic age from methylation profiles across CpG islands in individual cells are described. DNA methylation, which characterizes the function of the epigenetic clock, appears to link together such key biological processes as regeneration and functioning of stem cells, aging and malignant transformation. Finally, the main features of adult stem cell aging in stem cell niches and current possibilities for modulating the epigenetic clock and stem cells rejuvenation as part of antiaging therapy are discussed.
Spatiotemporal Analysis of Sea Ice Leads in the Arctic Ocean Retrieved from IceBridge Laxon Line Data 2012-2018

The ocean and atmosphere exert stresses on sea ice that create elongated cracks and leads which dominate the vertical exchange of energy, especially in cold seasons, despite covering only a small fraction of the surface. Motivated by the need of a spatiotemporal analysis of sea ice lead distribution, a practical workflow was developed to classify the high spatial resolution aerial images DMS (Digital Mapping System) along the Laxon Line in the NASA IceBridge Mission. Four sea ice types (thick ice, thin ice, open water, and shadow) were identified, and relevant sea ice lead parameters were derived for the period of 2012–2018. The spatiotemporal variations of lead fraction along the Laxon Line were verified by ATM (Airborne Topographic Mapper) surface height data and correlated with coarse spatial resolution sea ice motion, air temperature, and wind data through multiple regression models. We found that the freeboard data derived from sea ice leads were compatible with other products. The temperature and ice motion vorticity were the leading factors of the formation of sea ice leads, followed by wind vorticity and kinetic moments of ice motion.
Effects of egg laying week on some egg quality characteristics of Rock partridges (A. graeca)

Aim: In this study, it was aimed to determine the effects of egg-laying week on some egg quality characteristics of rock partridges. Materials and Methods: Quality characteristics of 160 partridge eggs obtained from 34-41 week ages were investigated. 144 rock partridges in 32 week of ages were used as research material Results: It was determined that the effects of egg-laying week on egg weight, shape index, yolk index, albumen index, egg shell weight, shell thickness, Haugh Unite, membrane weight and albumen weight were found statistically important (P<0.05). The effects of egg-laying week on yolk weight was found not important (P>0.05). Egg weight, shape index and yolk index of partridge eggs has been increased according to egg-laying week (P<0.05). While albumen index, shell membrane weight, shell membrane thickness has been decreased with the egg-laying week (P<0.05). Conclusion: Some internal and external quality characteristics of partridge eggs were determined and also the differences in these characteristics according to egg-laying week were investigated. it can be recommended further investigations should be carried out on the other factors effecting the quality characteristics of partridge eggs
A Systematic Review and Meta-Analytic Factor Analysis of the Depression Anxiety Stress Scales

[This paper is now published in Clinical Psychology: Science and Practice and can be accessed through http://dx.doi. org/10.1111/cpsp.12362. ] Despite the increasingly widespread usage of the Depression Anxiety Stress Scales (DASS), its latent factor structure has yet to be reviewed. We thus carried out a systematic review of studies examining the latent factor structure of the DASS, further synthesizing findings by performing meta-analytic factor analyses on the available data from said studies. The literature search was conducted across three databases, yielding 59 articles encompassing 89 factor analyses. Reviewed results varied across factor analytic approaches (EFA vs. CFA) and DASS versions (DASS42 vs. DASS21), though the original 3-factor structure of the DASS was generally supported. However, bifactor models (consisting of a general factor and group factors) were most consistently best-fitting whenever tested, supporting an underlying unidimensional construct in DASS. This notion was corroborated by our meta-analytic factor analyses, wherein DASS21 bifactor models demonstrated the same consistent performance, though DASS42 analyses were inconclusive between a 3-factor and 1-factor solution. Our findings fit in with broader historical and contemporary developments in the field, and reinforce the potential utility of bifactor models in illustrating the overlap between depression and anxiety. Some recommendations moving forward are discussed.
Preparation and evaluation of combined vaccine against necrotic enteritis and colibacillosis in chickens and detection of maternal immunity in their progeny

Necrotic enteritis (NE) caused by Clostridium perfringens type A and colibacillosis caused by Avian pathogenic E. coli (APEC), are two pathogenic diseases that threaten the poultry industry worldwide. A combined inactivated vaccine from Clostridium perfringens type A toxoid and serotypes O1 and O78 of E-coli adjvunated with montanide gel was prepared and evaluated in two weeks old SPF white Lohman layer chickens and its progeny. The prepared vaccine was found safe and produced antitoxic titre against NE of 10 IU after 22 week of vaccination as measured by serum neutralization test and 2692 ELISA titre. Also it produced a humeral antibody titre against E.coli serotypes used of 80 at the 22 th week post vaccination by microagglutination test (MAT) and an 80% protection in challenge against virulent E.coli serotypes used. Conclusion: vaccination of chicken with two doses, 3 weeks apart, of combined vaccine of Clostridium perfringens type A toxoid and serotypes O1 and O78 of E-coli adjvunated with montanide gel, could protect against necrotic enteritis and colibacillosis.
Gender Issues: The Effects of Differences in Interaction Styles between Genders and Roles on Workplace Communication

Issues related to gender in the workplace are quite a common and debatable issue in Malaysia considering that male employees dominate the working world in general. Gender issues at the workplace has become a problem in the workforce which in return brings negative impacts on the organisations involved as well as the victims themselves without regarding the gender. Given this situation, this study aims to explore the differences in the interaction styles between gender and gender roles in which we would look into how they affect the workplace communication. In addition, workplace has been a war field for female against gender issues. The questionnaires were distributed to the respondents with a working experience regardless of their employment status. A total of 33 questionnaires were completed by the respondents. This quantitative study used descriptive analysis approach in analysing the frequency which was presented in percentage. According to the results obtained it was revealed that most of our respondents agreed with our statements which aligned with our previous researches. Future researches should be conducted in order for these aspects in the issues to be included and discussed holistically.