Miracle-dz/UniFAR-FTUs huggingface dataset:
Chemical Composition, Antioxidant, Antibacterial, Antibiofilm, and Cytotoxic Activities of Robusta Coffee Extract (Coffea canephora)

Coffee extracts are a rich source of potential compounds with numerous biological activities. This study aimed to investigate the potential of chemical compounds derived from robusta coffee extract (Coffea canephora) and its dominant compound, caffeine, to scavenge free radicals, inhibit bacterial growth and biofilm formation, and cytotoxic properties in human breast adenocarcinoma cell line. Chemical constituents of coffee extract were analysed quantitively for total phenolic, flavonoid, and alkaloid contents, along with Liquid Chromatography Quadrupole-Mass Spectrometry (LC/MS–MS) analysis. Antioxidant activity was measured by 2,2-Diphenyl-1-picrylhydrazyl (DPPH) and 2,2'-azino-bis; 3-ethylbenzothiazoline-6-sulfonic acid (ABTS) methods. Antibacterial pair with antibiofilm properties against Escherichia coli, Pseudomonas aeruginosa, Bacillus subtilis, and Staphylococcus aureus were also determined, as well as cytotoxic activity on the MCF7 cell line model. The LC/MS–MS analysis of coffee extracts revealed high levels of caffeine; thus, the caffeine standard is used in all subsequent assays. Notably, robusta coffee extract showed remarkable antioxidant activity and selective inhibition of the growth against gram-positive and negative bacteria, along with the best inhibition of P. aeruginosa biofilm. However, compared with the caffeine standard, robusta coffee extract had lower cytotoxic activity and different bacterial targets in antibacterial and antibiofilm properties. Our results indicate that Robusta coffee extract is potentially a functional food due to its high alkaloid, phenolic, and flavonoid content and antioxidant activity, besides being used for natural compounds against bacterial infections.
Material Development for Additive Manufacturing: Compressive Loading Behavior of SLA 3D-Printed Thermosets with Nanosilica Powders

3D printing is now being used in many different applications. This adoption of 3D printing in these applications is accelerated by the development of new materials such as high performance polymers and nanocomposites. In this study, a commercially-available stereolithographic (SLA) resin has been reinforced with 0%, 0.1%, 0.3% and 0.5% nanosilica powder. The resulting mixture has been 3D-printed using a stereolithography 3d printer. The 3D-printed composites have been post-cured in a UV chamber and the mechanical properties have been assessed under compressive loading using a universal testing machine (ASTM-D695). The results show that adding nanosilica powder to the resin would increase the compressive strength of the resin, and that the highest compressive strength could be observed when 0.1% nanosilica poweder was added to the resin.
Molecular Characterization of Extensively Drug Resistant Salmonella Enterica Serovar Typhi Clinical Isolates from Lahore, Pakistan

Background The emergence of extensively drug-resistant (XDR) typhoid in Pakistan has endangered the treatment options available to manage this infection. Third generation cephalosporin were the empiric choice to treat typhoid fever in Pakistan, but acquisition of ESBLs have knocked them out of the arsenal. The current empiric choice is azithromycin which is vulnerable to resistance too. This study aimed to assess the burden of XDR typhoid and the frequency of resistance determinants in blood culture samples collected from different hospitals in Lahore, Pakistan. Methods A total of 835 blood cultures were collected from different tertiary care hospitals in Lahore during January 2019 to December 2021. Among 835 blood cultures, 389 Salmonella Typhi were identified, and 150 were XDR S. Typhi (resistant to all recommended antibiotics). Antibiotics resistance genes of the first-line drugs (blaTEM-1, catA1, sul1, and dhfR7) and second line drugs (gyrB, gyrA, qnrS, ParC and ParE) were investigated among XDR S. Typhi. There were different CTX-M genes isolated using the specific primers, blaCTX-M-U, blaCTX-M-1, blaCTX-M-15, blaCTX-M-2, blaCTX-M-8 and blaCTX-M-9. Results Antibiotic resistant genes of the first-line drugs were isolated with different frequency, blaTEM-1 (72.6%), catA1 (86.6%), sul1 (70%), and dhfR7 (56%). Antibiotics resistance genes of second-line drugs were isolated as: gyrB (60%), gyrA (49.3%), qnrS (32.6%), parC (44%) and parE (28%). Among CTX-M genes, blaCTX-M-U (63.3%) was the most frequent followed by blaCTX-M-15 (39.3%) and blaCTX-M-1 (26%). Conclusion Our study concluded that XDR isolates circulating in Pakistan have acquired first-line and second-line antibiotic resistant genes quite successfully along with CTX-M genes (ESBLs) rendering them resistant to the third generation cephalosporins as well. Emergence of azithromycin resistance in XDR S. Typhi which is currently used as an empiric treatment option is worrisome and needs to be monitored carefully in endemic countries like Pakistan.
Selection of a Forklift for a Cargo Company with Fuzzy BWM and Fuzzy MCRAT Methods

Material handling is a cost-intensive operation for businesses. There are several alternative types of equipment for material handling, therefore it is important to select the best one among them to decrease the cost. As there are several different alternatives and criteria which are used to assess these alternatives, multi-criteria decision making (MCDM) techniques are useful to determine the optimal material handling equipment (MHE) for businesses. In this study, fuzzy BWM for determining weights of criteria and the fuzzy Multiple Criteria Ranking by Alternative Trace (MCRAT) method have been used for ranking forklift alternatives. This study’s significance in the literature will be the creation of a novel fuzzy MCDM technique with the application of fuzzy MCRAT. Furthermore, there are relatively few studies employing the MCRAT approach in the literature; therefore, this study will provide additional data and outcomes from this method to the literature. The findings present that the forklift with the code FLT-3 performed the best, whereas the forklift with the code FLT-2 had the worst performance, according to the fuzzy MCRAT technique. According to the comparison analysis, the fuzzy MCRAT produced the same results as the fuzzy ARAS and had a few subtle differences to fuzzy MARCOS.
Exploring Relationships between Presage Variables of Florida Preservice Agricultural Education Teachers Related to Teaching Contextualized Mathematics.

The purpose of this exploratory study was to investigate the relationships between mathematics ability, personal mathematics efficacy, mathematics teaching efficacy, personal teaching efficacy, and background characteristics of preservice agricultural education teachers. Data were collected for two years at the University of Florida. Fourteen moderate associations were found between the variables in this study. In addition, categorical differences in mathematics ability, personal mathematics efficacy, mathematics teaching efficacy, and personal teaching efficacy were found related to presage variables of the preservice teachers. Based on the results of this study, further research is warranted to determine the most appropriate means for preparing Florida preservice agricultural education teachers for teaching contextualized mathematics.
Transition of creep mechanism in nanocrystalline metals

Understanding creep mechanisms with atomistic details is of great importance to achieve the mechanical and thermodynamical stabilities of nanocrystalline (NC) metals over a wide temperature range. Here we report a molecular dynamics analysis of creep in NC copper dominated by competing deformation mechanisms. We found the dominating creep mechanism transits from grain boundary (GB) diffusion to GB sliding, and then dislocation nucleation with increasing stress. The derived stress exponent, small activation volume of 0.1 − 10b3, and grain size exponent all agree quantitatively with experimental values. We proposed a stress-temperature deformation map in NC metals accommodated by the competition among different stress-driven, thermally activated processes. The model is general to answer the question why deformation mechanism transits with stress in NC metals.
The Artificial Intelligence in Teledermatology: A Narrative Review on Opportunities, Perspectives, and Bottlenecks

Artificial intelligence (AI) is recently seeing significant advances in teledermatology (TD), also thanks to the developments that have taken place during the COVID-19 pandemic. In the last two years, there was an important development of studies that focused on opportunities, perspectives, and problems in this field. The topic is very important because the telemedicine and AI applied to dermatology have the opportunity to improve both the quality of healthcare for citizens and the workflow of healthcare professionals. This study conducted an overview on the opportunities, the perspectives, and the problems related to the integration of TD with AI. The methodology of this review, following a standardized checklist, was based on: (I) a search of PubMed and Scopus and (II) an eligibility assessment, using parameters with five levels of score. The outcome highlighted that applications of this integration have been identified in various skin pathologies and in quality control, both in eHealth and mHealth. Many of these applications are based on Apps used by citizens in mHealth for self-care with new opportunities but also open questions. A generalized enthusiasm has been registered regarding the opportunities and general perspectives on improving the quality of care, optimizing the healthcare processes, minimizing costs, reducing the stress in the healthcare facilities, and in making citizens, now at the center, more satisfied. However, critical issues have emerged related to: (a) the need to improve the process of diffusion of the Apps in the hands of citizens, with better design, validation, standardization, and cybersecurity; (b) the need for better attention paid to medico-legal and ethical issues; and (c) the need for the stabilization of international and national regulations. Targeted agreement initiatives, such as position statements, guidelines, and/or consensus initiatives, are needed to ensure a better result for all, along with the design of both specific plans and shared workflows.
Sex Differences in the Inflammatory Profile in the Brain of Young and Aged Mice

Neurodegenerative diseases are a leading cause of death worldwide with no cures identified. Thus, there is a critical need for preventative measures and treatments as the number of patients is expected to increase. Many neurodegenerative diseases have sex-biased prevalence, indicating a need to examine sex differences when investigating prevention and treatment strategies. Inflammation is a key contributor to many neurodegenerative diseases and is a promising target for prevention since inflammation increases with age, which is known as inflammaging. Here, we analyzed the protein expression levels of cytokines, chemokines, and inflammasome signaling proteins in the cortex of young and aged male and female mice. Our results show an increase in caspase-1, interleukin (IL)-1β, apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC), and ASC specks in females compared to males. Additionally, there was an increase in IL-1α, VEGF-A, CCL3, CXCL1, CCL4, CCL17, and CCL22 in aging females and an increase in IL-8, IL-17a, IL-7, LT-α, and CCL22 in aging males. IL-12/IL-23p40, CCL13, and IL-10 were increased in females compared to males but not with age. These results indicate that there are sex differences in cortical inflammaging and provide potential targets to attenuate inflammation to prevent the development of neurodegenerative disease.
The Role of Work Engagement in Mediating Perceived Organizational Support and Organizational Commitment Relationship to Organizational Citizenship Behavior

This paper reviews the important role ofwork engagement (WE) in bridging the relationship between perceived organizational support (POS) and organizational commitment (OC) on organizational citizenship behavior (OCB) to private university lecturers. WE is one of the positive behaviors in the form of positive engagement cognitively, emotionally, and physically to increase productivity and morale. High WE is the main capital in creating lecturer OCB.Several previous studies have shown that high POS and OC have not consistently resulted in good OCB.With these considerations in mind, this study presents a WE thatbelieved to be able to strengthen POS and OC relations with OCB. It is hoped that this paper will provide a new perspective on the role of WE and other factors that can improve OCB for lecturers at private tertiary institutions. This study uses a quantitative approach and descriptive design. The research respondents were lecturers spread across 7 tertiary institutions in Baubau City. While data collection was carried out using digital instruments in the form of google forms which were distributed and managed to collect a sample of 257 respondents. The results of this study indicate thatWE has a significant positive influence in bridging the relationship between POS and OC towards OCB.This study suggests paying more attention to WE and OC because they have been proven to significantly contribute to increasing OCB in private university lecturers.
Secondary Prevention of Diabetes Type 1 with Oral Calcitriol and Analogs, the PRECAL Study

Screening for Type 1 Diabetes (T1D, incidence 1:300) with T1D autoantibodies (T1Ab) at ages 2 and 6, while sensitive, lacks a preventive strategy. Cholecalciferol 2000 IU daily since birth reduced T1D by 80% at 1 year. T1D-associated T1Ab negativized within 0.6 years with oral calcitriol in 12 children. To further investigate secondary prevention of T1D with calcitriol and its less calcemic analog, paricalcitol, we initiated a prospective interventional non-randomized clinical trial, the PRECAL study (ISRCTN17354692). In total, 50 high-risk children were included: 44 were positive for T1Ab, and 6 had predisposing for T1D HLA genotypes. Nine T1Ab+ patients had variable impaired glucose tolerance (IGT), four had pre-T1D (3 T1Ab+, 1 HLA+), nine had T1Ab+ new-onset T1D not requiring insulin at diagnosis. T1Ab, thyroid/anti-transglutaminase Abs, glucose/calcium metabolism were determined prior and q3–6 months on calcitriol, 0.05 mcg/Kg/day, or paricalcitol 1–4 mcg × 1–3 times/day p.o. while on cholecalciferol repletion. Available data on 42 (7 dropouts, 1 follow-up < 3 months) patients included: all 26 without pre-T1D/T1D followed for 3.06 (0.5–10) years negativized T1Ab (15 +IAA, 3 IA2, 4 ICA, 2 +GAD, 1 +IAA/+GAD, 1 +ICA/+GAD) within 0.57 (0.32–1.3) years or did not develop to T1D (5 +HLA, follow-up 3 (1–4) years). From four pre-T1D cases, one negativized T1Ab (follow-up 1 year), one +HLA did not progress to T1D (follow-up 3.3 years) and two +T1Ab patients developed T1D in 6 months/3 years. Three out of nine T1D cases progressed immediately to overt disease, six underwent complete remission for 1 year (1 month–2 years). Five +T1Ab patients relapsed and negativized again after resuming therapy. Four (aged <3 years) negativized anti-TPO/TG, and two anti-transglutaminase-IgA. Eight presented mild hypercalciuria/hypercalcemia, resolving with dose titration/discontinuation. Secondary prevention of T1D with calcitriol and paricalcitol seems possible and reasonably safe, if started soon enough after seroconversion.
A brief survey on nonlinear control using adaptive dynamic programming under engineering-oriented complexities

ABSTRACT Nonlinear dynamics is frequently encountered in practical applications. Adaptive dynamic programming (ADP), which is implemented via actor/critic neural networks with excellent approximation capabilities, is appropriate to be used in finding the solution for the control problem in the presence of known/unknown nonlinear dynamics. The objective of this paper is to introduce state-of-the-art ADP-based algorithms and survey the recent advances in the ADP-based control strategies for nonlinear systems with various engineering-oriented complexities. Firstly, the main motivation of the ADP-based algorithms is thoroughly discussed, and the way of implementing the ADP-based algorithms is highlighted. Then, the latest research results concerning ADP-based control policy design for nonlinear systems are reviewed in detail, Finally, we conclude the survey by outlining the challenges and possible research topics in the future.
SOLVABLE MATRIX REPRESENTATIONS OF K

In the paper we study solvable matrix representations of fundamental groups of compact Kahler manifolds (Kahler groups). One of our main re- sults is a factorization theorem for such representations. As an application we prove that the universal covering of a compact Kahler manifold with a residually solvable fundamental group is holomorphically convex.
The Role of Lumen Apposing Metal Stents in the Palliation of Distal Malignant Biliary Distal Obstruction

Simple Summary Obstruction of the distal bile duct caused by various tumors arising in the region of the bile tract and pancreas has been traditionally treated by surgical or endoscopic therapy. However, in several cases, either surgical or endoscopic therapy via the conventional approach is not technically feasible. Recent advances in endoscopy techniques allow safe and effective relief of obstruction using a novel endoscopic device–the lumen apposing metal stent–which can be delivered using an endoscopic ultrasonography-guided approach. Our review analyzes the data on efficacy and safety of this new technique, compared to the already available therapeutic methods. Abstract Malignant biliary obstruction (DMBO) has been traditionally managed by endoscopic retrograde cholangiopancreatography (ERCP). In the case of ERC failure, percutaneous transhepatic biliary drainage (PT-BD) has been widely utilized as a salvage procedure. However, over the last decade, endoscopic ultrasound-guided biliary drainage (EUS-BD) has gained increasing popularity, especially after the advent of electrocautery-enhanced lumen apposing metal stent devices (EC-LAMSs) which enable a one-step procedure, granting prevention of biliary leakage and minimizing occurrence of adverse events (AEs). In parallel, increasing evidence suggests a possible role of EUS-BD in the management of DMBO as a primary palliative drainage modality. In the current paper, we aim to review all the available evidence on the role of EUS-BD performed with EC-LAMSs and discuss salient technical aspects of this type of procedure.
Correlation Analysis in terms of Unsteady Aerodynamic Force and Flow Field Around a Flying Insect

The purpose of this investigation is to clarify the generation mechanism for the aerodynamic force from the flapping wings of insects. In this investigation, a quantitative analysis of vortex field around a dragonfly and an instantaneous aerodynamic force were measured directly using a dynamic PIV and a micro-load cell system. The experimental result showed that the feathering angle of the wing was kept at small value, which generated the leading-edge vortices in downstroke process. The negative pressure field of the leading-edge vortices makes large aerodynamic force in the downstroke process. In the upstroke process, the angle of attack of the flapping wing was smaller than that of the downstroke process. As a result, vortices were not generated, and then the negative aerodynamic force was reduced. These results revealed that the constant feathering angles of both processes play an important role in the aerodynamic force generated by the flapping wings of insects. Moreover, it indicated that the control of the feathering motion is key technology for the development of flappingMicro Air Vehicles.
Neurological Imaging

Procedure Appropriateness Category Relative Radiation Level MRI head without IV contrast Usually Appropriate O CT head without IV contrast Usually Appropriate ☢☢☢ Amyloid PET/CT brain May Be Appropriate ☢☢☢ FDG-PET/CT brain May Be Appropriate ☢☢☢ MRI head without and with IV contrast Usually Not Appropriate O HMPAO SPECT or SPECT/CT brain Usually Not Appropriate ☢☢☢☢ MR spectroscopy head without IV contrast Usually Not Appropriate O MRI functional (fMRI) head without IV contrast Usually Not Appropriate O CT head with IV contrast Usually Not Appropriate ☢☢☢ CT head without and with IV contrast Usually Not Appropriate ☢☢☢
The JRA-55 Reanalysis: Representation of Atmospheric Circulation and Climate Variability

This study investigates the quality of the Japanese 55-year Reanalysis (JRA-55), which is the second global reanalysis constructed by the Japan Meteorological Agency (JMA), by comparing it with other reanalyses and observational datasets. Improvements were found in the representation of atmospheric circulation on an isentropic surface and in the consistency of momentum budget based on the mass-weighted isentropic zonal mean method. The representation of climate variability in several regions was also examined. In the tropics, the frequencies of high spatial correlations with precipitation, which were estimated using the Tropical Rainfall Measuring Mission Multisatellite Precipitation Analysis, are clearly higher in JRA-55 than in JRA-25. The results indicate that JRA-55 generally improved the representations of phenomena on a wide range of space–time scales, such as equatorial waves, and transient eddies in the storm track regions, compared with JRA-25 during the satellite era. Moreover, JRA-55 improved the temporal consistency compared with the older reanalyses throughout the reanalysis period. In the stratosphere, we found larger discrepancies between reanalyses for the extra-tropical stratosphere during the Southern Hemisphere (SH) winter. Comparisons with radiosonde temperature revealed that JRA-55 has a smaller bias in temperature than the other reanalyses in the extra-tropical SH winter before 1979. Some issues in JRA-55 were also identified. The amplitude of equatorial waves and Madden–Julian oscillation in JRA-55 are weaker than in the other reanalyses. JRA-55 shows unrealistic strong cooling in South America and Australia, although the spatial distribution of the long-term temperature trends in JRA-55 is the closest to an observational dataset of global historical surface temperature.
Amplitude-dependent modal coefficients accounting for localized nonlinear losses in a time-domain integration of woodwind model

This article develops the design of a sound synthesis model of a woodwind instrument by modal decomposition of the input impedance, taking into account viscothermal losses as well as localized nonlinear losses at the end of the resonator. This formalism has already been applied by Diab et al. [Journal of Sound and Vibration 528 (2022) 116892] to the study of forced systems. It is now implemented for self-oscillating systems. The employed method extends the definition of the input impedance to the nonlinear domain by adding a dependance on the RMS acoustic velocity at a geometric discontinuity. The poles and residues resulting from the modal decomposition are fitted as a function of this velocity. Thus, the pressure-flow relation defined by the resonator is completed by new equations which account for the dependence with the velocity at the end of the tube. To assess the ability of the model to reproduce a real phenomenon, comparisons with the experimental results of Atig et al. [PhD thesis, Université du Maine (2004)] and Dalmont and Frappé [Journal of the Acoustical Society of America 122(2) (2007) 1173–1179] were carried out. Simulations show that the model reproduces these experimental results qualitatively and quantitatively.