Miracle-dz/UniFAR-FTUs huggingface dataset:
INTERLEUKIN-16 RS4778889 POLYMORPHISM AND ITS INTERACTION WITH INTERLEUKIN-10 RS1800896 POLYMORPHISM INCREASE THE RISK FOR KNEE OSTEOARTHRITIS IN THE LEBANESE POPULATION

To investigate the effect Interleukin-16 (IL-16) and Interleukin-10 (IL-10) polymorphisms, and their interaction, on knee osteoarthritis (KOA) risk in the Lebanese population. Kompetitive Allele Specific PCR (KASP) genotyping assay was performed to determine IL-16 rs4778889, rs11556218, and rs4072111 and IL-10 rs1800896 polymorphisms in 118 patients diagnosed with KOA ( ≥ 2 points on Kellgren-Lawrence (K&L) radiological classification scale) and 70 controls matched for age and gender (K&L score ≤ 1). After adjusting for age, gender, presence of metabolic disorders, smoking and drinking status, our findings suggest that rs4778889 TT genotype increases the risk for KOA compared to the combined CC and TC genotypes (OR=2.131, 95% CI 1.037 – 4.379, p = 0.04) and that the T allele increases KOA risk compared to the C allele (OR=1.8, 95% CI 1.008 – 3.212, p = 0.047). No significant associations with the disease risk were found for the other studied polymorphisms (p > 0.05). Our data suggest that there is an interaction between IL-16 rs4778889 and IL-10 rs1800896 (p = 0.010). IL-16 rs4778889 TT genotype increases the risk for KOA only among individuals carrying IL-10 rs1800896 GG or GA genotypes (OR=4.821, 95% CI 1.847 – 12.583). None of the IL-16 haplotypes was associated with KOA risk in our study population (p > 0.05). Our findings suggest that IL-16 rs4778889 T allele is associated with KOA and that there is an interaction between this polymorphism and IL-10 rs1800896 with regard to KOA.
Influence of Age on the Effects of Sodium-Glucose Cotransporter 2 Inhibitors in Japanese Patients With Type 2 Diabetes Mellitus

Background: Selective inhibitors of sodium-glucose cotransporter 2 (SGLT2) inhibitors have been reported to improve glucose metabolism, lipid metabolism and liver dysfunction in patients with type 2 diabetes mellitus. However, few studies have investigated if the effects of this class of drugs vary according to the age of the patients. This study was conducted to determine the influence of age on the effects of SGLT2 inhibitors in Japanese patients with diabetes mellitus. Methods: SGLT2 inhibitors were administered for 6 months to 199 patients with type 2 diabetes mellitus. The body weight, body mass index (BMI), visceral fat area, serum glucose, hemoglobin A1c (HbA1c), blood lipid levels, serum uric acid, liver function parameters, and bone mineral density were measured before and after 6 months of treatment, and regression analysis was performed to examine the relationship between age and the effects of SGLT2 inhibitors. Results: The results of the regression analysis showed that the effects of SGLT2 inhibitors on the serum levels of high-density lipoprotein cholesterol (HDL-C), aspartate aminotransferase (AST), and γ-glutamyl transpeptidase (γ-GTP) were influenced by the patient age. The effect of SGLT2 inhibitors in increasing the serum HDL-C was more pronounced in older patients. There was an interaction between age and the baseline levels of the serum AST and γ-GTP; reductions of the serum AST and γ-GTP levels by SGPLT2 inhibitors were more pronounced in younger patients with higher baseline levels of these parameters, but not pronounced in aged patients. Conclusions: The effects of SGLT2 inhibitor treatment on the serum HDL-C, AST and γ-GTP levels were affected by the patient age: their beneficial effect on the serum HDL-C increased with the patient age and their effects in reducing the serum AST and γ-GTP decreased with the patient age. The effects of SGLT2 inhibitor treat-ment on the blood glucose and serum HbA1c were not affected by the patient age, suggesting that SGLT2 inhibitors can be used as antidiabetic drugs in patients over a wide age range, from the young to the elderly.
How emotional labor affects job performance in hospitality employees

The study examines how surface acting and deep acting affect emotional exhaustion and job performance in the hotel industry and whether emotional intelligence has a moderating effect on the relationship. The study was conducted using a questionnaire survey, and the data were analyzed using a structural equation model. The main findings of the study demonstrate that surface acting has no effect on emotional exhaustion while deep acting has a negative effect on emotional exhaustion. This indicates that deep acting not only produces better service performance but also reduces emotional exhaustion. Moreover, surface acting and deep acting both have a positive effect on job performance, showing that both acting skills are all about demonstrating a better job performance at work. Furthermore, emotional intelligence has a moderating effect on the relationships between surface acting and job performance and deep acting and job performance, this indicates that employees with higher emotional intelligence are more likely to perform a more effective outcome of acting on job performance, regardless of whether it is surface acting or deep acting. But this phenomenon only occurs when employees are not experiencing emotional exhaustion. If employees are already experiencing emotional exhaustion, emotional intelligence does not have any moderation effect on job performance.
Flow diverter stents simulation with CFD: porous media modelling

Intracranial aneurysm treatment with flow diverters stent (FDs) is a minimally invasive approach for use in human patients. Because this treatment is strongly related to blood flow, flow simulation by CFD is an attractive method to study FDs. Such flow simulations generally define geometries of aneurysms and stents in the computation by creating calculation meshes in the fluid space. For the other hand, generating a mesh in porous media (PM) sometimes represents a smaller computational load than generating realistic stent geometries with CFD, particularly for the small gaps between stent struts. For this reason, PMs become attractive to simulate FDs. To find the proper parameters, we investigated Darcy-Forchheimer model for porous media. The model describes the relation between the pressure drop and flow velocity considering a viscous permeability (linear model's term), and an inertial permeability (quadratic model's term). Finally, two stage studies were performed. First, we verified flow model validity at different angles in known flow conditions. Second, model validation was checked for a channel with no-slip boundary conditions. Results indicate that resistance calculated according to model has a difference of less than 3.5 % which is appropriate to characterize the FDs.
A Time-Series Analysis of Selected Economic Indicators Affecting Inflation in the Philippines: 2003-2020

The Philippines is a country that has been experiencing a gradual rise in inflation in the past decades, and this affects the prices of goods and services, therefore decreasing the currency's purchasing power. The aim of this study is to analyze the relationship between Inflation and selected economic indicators, such as Unemployment Rate, Money Supply, Policy Rate, and Exchange Rate, based on time series quarterly data from the year 2003 to 2020 in the Philippines. This effect was investigated using the autoregressive distributed lag (ARDL) cointegration technique. The results showed that Inflation, which is the rate of increase in prices over a given period in the Philippines, has a significant positive relationship with the Policy rate in the short run.
Women's Mobility and Labor Supply: Experimental Evidence from Pakistan

In cities with conservative norms or high crime, female workers may face greater restrictions on their physical mobility. This limits women’s labor market opportunities and the pool of workers that firms can attract. In this study, we experimentally vary access to a transport service in Lahore, Pakistan, to quantify the overall impact of transport to work on men, women, and the differential impact of transport exclusively for women. We show that reducing physical mobility constraints has a large impact on job searching for women, including women who are not searching at baseline. Women’s response is driven by a women-only transport treatment arm, suggesting that safety and social acceptability, rather than simply cost, are key constraints.
Global prediction of the energy yields for hybrid perovskite/Si tandem and Si heterojunction single solar modules

A strong expectation exists for a two‐terminal hybrid perovskite/silicon tandem solar cell for generating substantially higher output power. Nevertheless, a high tandem cell efficiency under the standard condition does not guarantee high power generation in outdoor environment due to the requirement of current matching in a tandem device. Here, we predict the global energy yields of hybrid perovskite/Si tandem and Si heterojunction single modules by establishing a new rigorous self‐consistent model that performs full device simulations incorporating all fundamental time‐varying parameters affecting the module power output. In particular, the temperature dependences of the optical and electrical characteristics are modeled explicitly and reliable model parameters are extracted from an industry‐compatible Si heterojunction single cell (23.27% efficiency with a 120 μm wafer thickness), whereas ideal cell characteristics are assumed for a hybrid perovskite top cell. Our simulation approach is justified from the remarkable agreement with experimental results. We find that the tandem architecture improves a module energy yield in all places by a maximum of 1.6 times, compared with a state‐of‐the‐art Si heterojunction single module. Importantly, the annual energy yields of the tandem and single modules scale linearly with annual sun irradiation, even with the requirement of the current matching in the case of the tandem device, and the ratio of the tandem and single energy yields is governed essentially by the module efficiency ratio obtained under standard conditions. We have further revealed the climate‐dependent energy yield variation with a magnitude of ~5% based on Köppen‐Geiger climate classification. Moreover, the optimization of the top‐cell band gap based on real meteorological data shows that the optimum top‐cell gap needs to be increased at a place with a lower solar irradiation.
Evaluasi Pelaksanaan Asesmen Nasional Berbasis Komputer di Sekolah Dasar Terpencil

Berawal dari sistem evaluasi tahap akhir terhadap pendidikan dasar dan menengah. Pelaksanaan evaluasi tahap akhir itu memiliki permasalahan yang terus bertambah. Apalagi sejak Indonesia terkena pandemi (wabah) Covid-19 permasalahannya mewajibkan kegiatan belajar dan mengajar dilakukan secara daring. Mulai tahun 2020, pemerintah melalui Kementerian Pendidikan dan Kebudayaan menghapus Ujian Nasional dan diganti dengan Asesmen Nasional Berbasis Komputer. Asesmen Nasional bertujuan sebagai tanda ada perubahan paradigma penilaian pendidikan dasar dan menengah. Penelitian yang dilaksanakan di SDN Remo, sekolah dasar negeri yang berada di daerah terpencil bertujuan untuk mengetahui bagaimana evaluasi pelaksanaan ANBK. Penelitian dilaksanakan dengan menampilkan aturan pendekatan deskriptif kualitatif melalui instrumen observasi, wawancara, dan dokumentasi. Hasil penelitian menunjukkan jika pelaksanaan ANBK di SDN Remo memiliki hambatan sinyal internet, sarana dan prasarana, serta rendahnya tingkat pemahaman siswa terhadap ANBK. Hasil observasi menunjukkan peserta didik belum pernah memakai laptop, mengoperasikan, dan menggunakan mouse saat pelaksanaan ANBK. Hasil laporan ANBK menunjukkan aspek literasi dan numerasi peserta didik telah mencapai batas kompetensi minimum sedangkan aspek karakter telah berkembang. Di dalam pelaksanaan penelitian tersebut, peneliti melihat dan merasakan secara langsung proses pelaksanaan ANBK di SDN Remo yang berlangsung pada bulan November 2021.
Investigation of Storytelling as a Requirements Elicitation Method for Medical Devices

Medical device usability directly impacts the practitioner’s ability to perform their diagnostic task in an effective, efficient, and safe manner. A device with poor usability may frustrate the practitioner, increasing the worker’s stress level in a high-stress work environment. In addition, a device with poor usability may facilitate operator error, increasing the patient’s risk of injury. Designers of healthcare systems and devices face a unique conundrum that has been documented in the literature (Martin, Murphy, Crowe, & Norris, 2006; Martin, Norris, Murphy, & Crowe, 2007; Ward & Clarkson, 2007). Standards require the use of user research techniques, yet patient privacy standards prevent designers from observing users in context. The inability to observe users in their work environment impedes understanding the context-of-use. Since understanding context-of-use is required to ensure usability, further exploration into alternative methods for requirements gathering is needed. This study explored the storytelling as an elicitation method for medical device requirements by comparing the information elicited from nurses during requirements gathering for an infusion pump by two methods: focus groups followed by interviews (Group #1) and focus groups followed by storytelling sessions (Group #2). Results suggest further exploration of storytelling is warranted as Group #2 contributed similar quantity and breadth of information in significantly less time. Results also indicate potential support for the efficacy of storytelling within the healthcare domain as Group #2 participants contributed more distinct context-of-use information with an emphasis on the social context. Contributions of this study include a plan for mixed-method data analysis, a protocol for conducting a storytelling session, and a framework for defining requirements within the healthcare
Generation of Inducible BCL11B Knockout in TAL1/LMO1 Transgenic Mouse T Cell Leukemia/Lymphoma Model

The B-cell CLL/lymphoma 11B gene (BCL11B) plays a crucial role in T-cell development, but its role in T-cell malignancies is still unclear. To study its role in the development of T-cell neoplasms, we generated an inducible BCL11B knockout in a murine T cell leukemia/lymphoma model. Mice, bearing human oncogenes TAL BHLH Transcription Factor 1 (TAL1; SCL) or LIM Domain Only 1 (LMO1), responsible for T-cell acute lymphoblastic leukemia (T-ALL) development, were crossed with BCL11B floxed and with CRE-ER/lox mice. The mice with a single oncogene BCL11Bflox/floxCREtg/tgTAL1tg or BCL11Bflox/floxCREtg/tgLMO1tg were healthy, bred normally, and were used to maintain the mice in culture. When crossed with each other, >90% of the double transgenic mice BCL11Bflox/floxCREtg/tgTAL1tgLMO1tg, within 3 to 6 months after birth, spontaneously developed T-cell leukemia/lymphoma. Upon administration of synthetic estrogen (tamoxifen), which binds to the estrogen receptor and activates the Cre recombinase, the BCL11B gene was knocked out by excision of its fourth exon from the genome. The mouse model of inducible BCL11B knockout we generated can be used to study the role of this gene in cancer development and the potential therapeutic effect of BCL11B inhibition in T-cell leukemia and lymphoma.
Implementation of the new higher education curriculum in Indonesia: perceptions and participation in the process

According to the objectives of this study, perceptions, and participation of the user community in responding to policy "Independent Learning Program – Independent Campus (MBKM)" will be determined. The quantitative approach used in this study was centered on the survey as the research design chosen for the study. It surveyed 593 members of the user community, who included lecturers, students, stakeholders, and parents, among other people. The structural equation model statistical analysis is used for data analysis. On the other hand, perceptions and participation are variables that have been observed. In this study, the relationship between perception and participation among the user community in responding to the policy of the MBKM program in Indonesia was investigated using quantitative methods. The following research procedures were used: (1) Exploratory Factor Analysis (EFA) was used to determine the factor analysis of each construct; perceptions and participation; (2) Confirmatory Factor Analysis (CFA) was used to construct the instrument in order to obtain a fit model; and (3) Structural Equation Model (SEM) was used to determine the relationship between perceptions and user participation. The fit index test was performed using the following model criteria: Chi-Square, Chi-Square/df, TLI, CFI, NFI, and RMSEA. In addition, the following are the findings of this study: (1) The EFA analysis revealed that the perceptions construct contained three valid sub-constructs, while the user participation constructs contained four valid sub-constructs; (2) The CFA analysis revealed that there was a strong link between the three sub-constructs of perceptions and the four valid sub-constructs of user participation (benefits, convenience, and beliefs; 0,943; 0,970; 0,870 respectively).
A retrospective study of physical fitness and mental health among police students in Sweden

Little is known about the physical and mental health among police students. Based on data on Swedish police students’ physical fitness (N = 1736) and mental health (N = 407), the results show that: (a) there are gender differences; (b) the physical fitness changes during police education; in general, the students get stronger but less flexible, and the aerobic endurance increases for women but decreases for men; and (c) students’ self-reported physical activity and mental health affect their perceived police ability differently in relation to gender. Consequently, this study questions if the Swedish police education is preparing the students adequately for their future profession.
Design of a Naturally Dyed and Waterproof Biotechnological Leather from Reconstituted Cellulose

Consumerism in fashion involves the excessive consumption of garments in modern capitalist societies due to the expansion of globalisation, especially at the beginning of the 21st Century. The involvement of new designers in the garment industry has assisted in creating a desire for new trends. However, the fast pace of transitions between collections has made fashion increasingly frivolous and capable of generating considerable interest in new products, accompanied by an increase in the discarding of fabrics. Thus, studies have been conducted on developing sustainable textile materials for use in the fashion industry. The aim of the present study was to evaluate the potential of a vegan leather produced with a dyed, waterproof biopolymer made of reconstituted bacterial cellulose (BC). The dying process involved using plant-based natural dyes extracted from Allium cepa L. , Punica granatum, and Eucalyptus globulus L. The BC films were then shredded and reconstituted to produce uniform surfaces with a constant thickness of 0.10 cm throughout the entire area. The films were waterproofed using the essential oil from Melaleuca alternifolia and wax from Copernicia prunifera. The characteristics of the biotechnological vegan leather were analysed using scanning electron microscopy (SEM), thermogravimetric analysis (TGA), flexibility and mechanical tests, as well as the determination of the water contact angle (°) and sorption index (s). The results confirmed that the biomaterial has high tensile strength (maximum: 247.21 ± 16.52 N) and high flexibility; it can be folded more than 100 times at the same point without breaking or cracking. The water contact angle was 83.96°, indicating a small water interaction on the biotextile. The results of the present study demonstrate the potential of BC for the development of novel, durable, vegan, waterproof fashion products.
Basophil Activation Test Utility as a Diagnostic Tool in LTP Allergy

Plant-food allergy is an increasing problem, with nonspecific lipid transfer proteins (nsLTPs) triggering mild/severe reactions. Pru p 3 is the major sensitizer in LTP food allergy (FA). However, in vivo and in vitro diagnosis is hampered by the need for differentiating between asymptomatic sensitization and allergy with clinical relevance. The basophil activation test (BAT) is an ex vivo method able to identify specific IgE related to the allergic response. Thus, we aimed to establish the value of BAT in a precise diagnosis of LTP-allergic patients. Ninety-two individuals with peach allergy sensitized to LTP, Pru p 3, were finally included, and 40.2% of them had symptoms to peanut (n = 37). In addition, 16 healthy subjects were recruited. BAT was performed with Pru p 3 and Ara h 9 (peanut LTP) at seven ten-fold concentrations, and was evaluated by flow cytometry, measuring the percentage of CD63 (%CD63+) and CD203c (%CD203chigh) cells, basophil allergen threshold sensitivity (CD-Sens), and area under the dose–response curve (AUC). Significant changes in BAT parameters (%CD63+ and %CD203chigh) were found between the controls and patients. However, comparisons for %CD63+, %CD203chigh, AUC, and CD-Sens showed similar levels among patients with different symptoms. An optimal cut-off was established from ROC curves, showing a significant positive percentage of BAT in patients compared to controls and great values of sensitivity (>87.5%) and specificity (>85%). In addition, BAT showed differences in LTP-allergic patients tolerant to peanut using its corresponding LTP, Ara h 9. BAT can be used as a potential diagnostic tool for identifying LTP allergy and for differentiating peanut tolerance, although neither reactivity nor sensitivity can distinguish the severity of the clinical symptoms.
2 Phospholipases A Induced by Group IIA and Group X Secreted Factors from Human Lung Macrophages Production of Vascular Endothelial Growth

Angiogenesis and lymphangiogenesis mediated by vascular endothelial growth factors (VEGFs) are main features of chronic inﬂammation and tumors. Secreted phospholipases A 2 (sPLA 2 s) are overexpressed in inﬂammatory lung diseases and cancer and they activate inﬂammatory cells by enzymatic and receptor-mediated mechanisms. We investigated the effect of sPLA 2 s on the production of VEGFs from human macrophages puriﬁed from the lung tissue of patients undergoing thoracic surgery. Primary macrophages express VEGF-A, VEGF-B, VEGF-C, and VEGF-D at both mRNA and protein level. Two human sPLA 2 s (group IIA and group X) induced the expression and release of VEGF-A and VEGF-C from macrophages. Enzymatically-inactive sPLA 2 s were as effective as the active enzymes in inducing VEGF production. Me-Indoxam and RO092906A, two compounds that block receptor-mediated effects of sPLA 2 s, inhibited group X-induced release of VEGF-A. Inhibition of the MAPK p38 by SB203580 also reduced sPLA 2 -induced release of VEGF-A. Supernatants of group X-activated macrophages induced an angiogenic response in chorioallantoic membranes that was inhibited by Me-Indoxam. Stimulation of macrophages with group X sPLA 2 in the presence of adenosine analogs induced a synergistic increase of VEGF-A release and inhibited TNF- a production through a cooperation between A 2A and A 3 receptors. These results demonstrate that sPLA 2 s induce production