Miracle-dz/UniFAR-FTUs huggingface dataset:
Perioperative cerebral perfusion in aortic arch surgery: a potential link with neurological outcome

Abstract OBJECTIVES The aim of this study was to examine whether perioperative changes in cerebral blood flow (CBF) relate to postoperative neurological deficits in patients undergoing aortic arch surgery involving antegrade selective cerebral perfusion (ASCP). METHODS We retrospectively analysed data from patients who underwent aortic arch surgery involving ASCP and perioperative transcranial Doppler assessments. Linear mixed-model analyses were performed to examine perioperative changes in mean bilateral blood velocity in the middle cerebral arteries, reflecting changes in CBF, and their relation with neurological deficits, i.e. ischaemic stroke and/or delirium. Logistic regression analyses were performed to explore possible risk factors for postoperative neurological deficits. RESULTS In our study population (N = 102), intraoperative blood velocities were lower compared to preoperative levels, and lowest during ASCP. Thirty-six (35%) patients with postoperative neurological deficits (ischaemic stroke, n = 9; delirium, n = 25; both, n = 2) had lower blood velocity during ASCP compared to patients without (25.4 vs 37.0 cm/s; P = 0.002). Logistic regression analyses revealed lower blood velocity during ASCP as an independent risk factor for postoperative neurological deficits (odds ratio = 0.959; 95% confidence interval: 0.923, 0.997; P = 0.037). CONCLUSIONS Lower intraoperative CBF during ASCP seems independently related to postoperative neurological deficits in patients undergoing aortic arch surgery. Because CBF is a modifiable factor during ASCP, our observation has significant potential to improve clinical management and prevent neurological deficits.
The effect of verb’s inflectional entropy on the processing of reflexive objects.

Consider the minimal pair: a. Maria prijst/ helpt zichzelf Maria praises/ helps herself b. Maria prijst/ helpt Kathrin Maria praises/ helps Kathrin Interpretation of zichzelf requires an intra-sentential referent while Kathrin does not. We use an information-theoretical measure to quantify processing complexity, namely the inflectional entropy of the verbal paradigm, a measure that reflects how an inflectional paradigm is organized in long term memory (LTM). We show that interpretation of a referentially dependent lexical item like zichzelf requires an operation on the verb itself because its speed of processing is modulated by the complexity of the verb as quantified by the inflectional entropy of its paradigm. More precisely, the value of the inflectional entropy influences the speed of activation of an inflected verb type from LTM as well as its re-accessing in working memory (WM). Furthermore, we argue that the speed is modulated according to the principle “what is easier to activate is harder to re-access”. In our experimental study, we used the self-paced reading task, measuring reading times at the point of the verb and at that of the object. We attested that verbs belonging to high entropy paradigms are retrieved faster than those belonging to low entropy paradigms. Crucially, when the verb is re-accessed, as in the cases of referentially dependent objects like zichzelf, verbs with high inflectional entropy delay the interpretation of the object, as reflected by the longer reading times. In other words, zichzelf is processed faster when it is the object of a praise-type verb (low inflectional entropy) than when it is the object of a help-type verb (high inflectional entropy).
Age-related variations in corneal stress-strain index in the Indian population

Purpose: To report age-related variations in corneal stress–strain index (SSI) in healthy Indians. Methods: It was a retrospective study where healthy Indian individuals aged between 11 and 70 years who had undergone corneal biomechanics assessment using Corvis ST between January 2017 and December 2021 were enrolled. Composite corneal biomechanical parameters and corneal SSI were abstracted from Corvis ST and compared across different age groups using one-way analysis of variance (ANOVA). Also, Pearson's correlation was used to evaluate the association between age and SSI. Results: Nine hundred and thirty-six eyes of 936 patients with ages between 11 and 77 years with mean ± SD intraocular pressure (IOP) and pachymetry of 16.52 ± 2.10 mmHg and 541.13 ± 26.39 μs, respectively. Composite corneal biomechanical parameters such as deformation amplitude ratio max at 1 mm (P < 0.001) and 2 mm (P < 0.001), biomechanically corrected IOP (P = 0.004), stiffness parameter at A1 (P < 0.001, Corvis biomechanical index (P < 0.018), and SSI (P < 0.001) were found to be significantly different as a function of age group. We noted a statistically significant positive association of SSI with age (P < 0.001), spherical equivalent refractive error (P < 0.001), and IOP (P < 0.001) and a significant negative association with anterior corneal astigmatism (P < 0.001) and Anterior chamber depth (ACD) (P < 0.001). Also, SSI was positively associated with SPA1 and bIOP, whereas negatively associated with integrated radius, max inverse radius, and Max Deformation amplitude (DA) ratio at 1 mm and 2 mm. Conclusion: We noted a positive association of corneal SSI with age in normal healthy Indian eyes. This information could be helpful for future corneal biomechanical research.
The prevalence of influenza bacterial co-infection and its role in disease severity: A systematic review and meta-analysis

Background Evidence suggests that influenza bacterial co-infection is associated with severe diseases, but this association has not been systematically assessed. We aimed to assess the prevalence of influenza bacterial co-infection and its role in disease severity. Methods We searched PubMed and Web of Science for studies published between 1 January 2010 and 31 December 2021. We performed a generalised linear mixed effects model to estimate the prevalence of bacterial co-infection in influenza patients, and the odds ratios (OR) of death, intensive care unit (ICU) admission, and requirement of mechanical ventilation (MV) for influenza bacterial co-infection compared to influenza single-infection. Using the estimates of OR and prevalence, we estimated the proportion of influenza deaths attributable to bacterial co-infection. Results We included 63 articles. The pooled prevalence of influenza bacterial co-infection was 20.3% (95% confidence interval (CI) = 16.0-25.4). Compared with influenza single-infection, bacterial co-infection increased the risk of death (OR = 2.55; 95% CI = 1.88-3.44), ICU admission (OR = 1.87; 95% CI = 1.04-3.38), and requirement for MV (OR = 1.78; 95% CI = 1.26-2.51). In the sensitivity analyses, we found broadly similar estimates between age groups, time periods, and health care settings. Likewise, while including studies with a low risk in confounding adjustment, the OR of death was 2.08 (95% CI = 1.44-3.00) for influenza bacterial co-infection. Based on these estimates, we found that approximately 23.8% (95% uncertainty range = 14.5-35.2) of influenza deaths were attributable to bacterial co-infection. Conclusions We found that bacterial co-infection is associated with a higher risk of severe illnesses compared to influenza single-infection. Approximately one in four influenza deaths could be attributable to bacterial co-infection. These results should inform prevention, identification, and treatment for suspected bacterial co-infection in influenza patients. Registration PROSPERO CRD42022314436.
Early life adversity predicts an accelerated cellular aging phenotype through early timing of puberty

Abstract Background The current study examined if early adversity was associated with accelerated biological aging, and if effects were mediated by the timing of puberty. Methods In early mid-life, 187 Black and 198 White (Mage = 39.4, s.d.age = 1.2) women reported on early abuse and age at first menstruation (menarche). Women provided saliva and blood to assess epigenetic aging, telomere length, and C-reactive protein. Using structural equation modeling, we created a latent variable of biological aging using epigenetic aging, telomere length, and C-reactive protein as indicators, and a latent variable of early abuse using indicators of abuse/threat events before age 13, physical abuse, and sexual abuse. We estimated the indirect effects of early abuse and of race on accelerated aging through age at menarche. Race was used as a proxy for adversity in the form of systemic racism. Results There was an indirect effect of early adversity on accelerated aging through age at menarche (b = 0.19, 95% CI 0.03–0.44), in that women who experienced more adversity were younger at menarche, which was associated with greater accelerated aging. There was also an indirect effect of race on accelerated aging through age at menarche (b = 0.25, 95% CI 0.04–0.52), in that Black women were younger at menarche, which led to greater accelerated aging. Conclusions Early abuse and being Black in the USA may both induce a phenotype of accelerated aging. Early adversity may begin to accelerate aging during childhood, in the form of early pubertal timing.
Comparison of LSO and BGO block detectors for prompt gamma imaging in ion beam therapy

A major weakness of ion beam therapy is the lack of tools for verifying the particle range in clinical routine. The application of the Compton camera concept for the imaging of prompt gamma rays, a by-product of the irradiation correlated to the dose distribution, is a promising approach for range assessment and even three-dimensional in vivo dosimetry. Multiple position sensitive gamma ray detectors arranged in scatter and absorber planes, together with an imaging algorithm, are required to reconstruct the prompt gamma emission density map. Conventional block detectors deployed in Positron Emission Tomography (PET), which are based on Lu2SiO5:Ce (LSO) and Bi4Ge3O12 (BGO) scintillators, are suitable candidates for the absorber of a Compton camera due to their high density and absorption efficiency with respect to the prompt gamma energy range (several MeV). We compare experimentally LSO and BGO block detectors in clinical-like radiation fields in terms of energy, spatial and time resolution. The high energy range compensates for the low light yield of the BGO material and boosts significantly its performance compared to the PET scenario. Notwithstanding the overall superiority of LSO, BGO catches up in the field of prompt gamma imaging and can be considered as a competitive alternative to LSO for the absorber plane due to its lower price and the lack of intrinsic radioactivity.
Workplace mental health screening: a systematic review and meta-analysis

Workplaces are an important location for population mental health interventions. Screening to detect employees at risk of or experiencing mental ill health is increasingly common. This systematic review and meta-analysis examined the efficacy of workplace mental health screening programmes on employee mental health, work outcomes, user satisfaction, positive mental health, quality of life, help-seeking and adverse effects. PubMed, PsycINFO, EMBASE, CENTRAL, Global Index Medicus, Global Health and SciELO were searched (database inception–10 November 2022) and results screened by two independent reviewers. Controlled trials evaluating screening of workers’ mental health as related to their employment were included. Random effects meta-analysis was performed to calculate pooled effect sizes for each outcome of interest. Grading of Recommendations Assessment, Development and Evaluation was conducted to evaluate the certainty of findings. Of the 12 328 records screened, 11 were included. These reported 8 independent trials collectively assessing 2940 employees. Results indicated screening followed by advice or referral was ineffective in improving employee mental health symptoms (n=3; d=−0.07 (95% CI −0.29 to 0.15)). Screening followed by facilitated access to treatment interventions demonstrated a small improvement in mental health (n=4; d=−0.22 (95% CI −0.42 to –0.02)). Limited effects were observed for other outcomes. Certainty ranged from low to very low. The evidence supporting workplace mental health screening programmes is limited and available data suggest mental health screening alone does not improve worker mental health. Substantial variation in the implementation of screening was observed. Further research disentangling the independent effect of screening alongside the efficacy of other interventions to prevent mental ill health at work is required.
A Survey on the Laplacian-Energy-Like Invariant ∗

Let G be a simple graph of order n ,a nd letμ1 ≥ μ2 ≥ · ·· ≥ μn =0b e the Laplacian spectrum of G. The Laplacian-energy-like invariant of G, LEL for short, is defined as LEL(G )= � n−1 i=1 √ μi. In this paper, we survey results on LEL, with
Cardiovascular risk factors in secondary progressive multiple sclerosis: A cross‐sectional analysis from the MS‐STAT2 randomized controlled trial

There is increasing evidence that cardiovascular risk (CVR) contributes to disability progression in multiple sclerosis (MS). CVR is particularly prevalent in secondary progressive MS (SPMS) and can be quantified through validated composite CVR scores. The aim was to examine the cross‐sectional relationships between excess modifiable CVR, whole and regional brain atrophy on magnetic resonance imaging, and disability in patients with SPMS.
THE SEASONS

Percival Stockdale, the poet, critic, and rival of Samuel Johnson, is better known today as a footnote within Johnson scholarship than for his own work as annotator.1 This essay will seek to recover something of Stockdale’s achievement as annotator by focusing on the notes, along with the dedication, that Stockdale contributed to Archibald Hamilton’s 1793 edition of James Thomson’s The Seasons. Although Stockdale was not offered the task until late 1792 when the edition was nearly ready to print, the paratexts won mention in the title when the first installment appeared in January 1793: The Seasons by James Thomson; with his Life, an Index, and Glossary. A Dedication to the Earl of Buchan, and Notes to the Seasons, by Percival Stockdale.2 Aimed less to explicate The Seasons than to refute Johnson’s unenthusiastic “Life of Thomson,” Stockdale’s notes construct Thomson as a “glorious Caledonian poet,” that is, as a poet operating in an anti-Unionist literary tradition rooted in a quasi-mythic past of Scottish independence. Stockdale was an Englander and no friend to Scotland, yet the need to distance himself from the notorious Scotophobe Johnson overruled Stockdale’s own anti-Scots prejudice, leading him to adopt a Scottish-nationalist rhetoric similar to that of his dedicatee, the antiquarian David Steuart Erskine, eleventh Earl of Buchan. A decade later, Stockdale renounced Buchan’s nationalism, implying that the 1793 paratexts did not reflect Stockdale’s personal attitudes on Scotland. But for reading audiences in 1793, this recantation came too late: as this essay will demonstrate, Stockdale’s paratexts encouraged readers to view Thomson as a Scottish poet and The Seasons as a specifically Scottish production.
The Nonlinear Relationship Between Body Mass Index (BMI) and Perceived Depression in the Chinese Population

Purpose Existing studies on the association between BMI and depression report conflicting results with some demonstrating a positive relationship, while others a negative link or insignificant correlation. Very limited research on the nonlinear relationship between BMI and depression has yet to clarify the reliability and robustness of the potential nonlinearity and whether a more complex association exists. This paper aims to systematically investigate the nonlinear relationship between the two factors applying rigorous statistical methods, as well as explore the heterogeneity of their association. Materials and Methods A large-scale nationally representative dataset, Chinese General Social Survey, is used to empirically analyze the nonlinear relationship between BMI and perceived depression. Various statistical tests are employed to check the robustness of the nonlinearity. Results Results indicate that there is a U-shaped relationship between BMI and perceived depression, with the turning point (25.718) very close to while slightly larger than the upper limit of the range of healthy weight (18.500 ≤ BMI < 25.000) defined by World Health Organization. Both very high and low BMIs are associated with increased risk for depressive disorders. Furthermore, perceived depression is higher at almost all BMI levels among individuals who are older, female, lower educated, unmarried, in rural areas, belonging to ethnic minorities, non-Communist Party of China members, as well as those with lower income and uncovered by social security. In addition, these subgroups have smaller inflection points and their self-rated depression is more sensitive to BMI. Conclusion This paper confirms a significant U-shaped trend in the association between BMI and depression. Therefore, it is important to account for the variations in this relationship across different BMI categories when using BMI to predict depression risk. Besides, this study clarifies the management goals for achieving an appropriate BMI from a mental health perspective and identifies vulnerable subgroups at higher risk of depression.
Sensor-supported measurement of adaptability of dogs (Canis familiaris) to a shelter environment: Nocturnal activity and behavior

Every shelter dog is faced with the challenge to adapt to a kennel environment. To monitor the welfare of individual shelter dogs, evaluating behavioural and physiological parameters, potentially useful as indicators for adaptability of individual dogs is crucial. Nocturnal activity, i.e. resting patterns, has already been identified as a candidate indicator of adaptability and can be easily measured remotely with the help of sensors. We investigated the usefulness of a 3-axial accelerometer (Actigraph®) to monitor nocturnal activity in shelter dogs every night during the full first two weeks in-shelter starting directly at shelter intake, as a measure of welfare. Additionally, urinary cortisol/creatinine ratio (UCCR), body weight and behaviour data were collected to evaluate stress responses. A control group of pet dogs in homes, matched to the shelter dog group, was also monitored. Shelter dogs had higher nocturnal activity and UCCRs than pet dogs, especially during the first days in the shelter. Nocturnal activity, both accelerometer measures and activity behaviour, and UCCRs decreased over nights in the shelter. Smaller dogs had higher nocturnal activity and UCCRs than larger dogs and showed less autogrooming during the first nights. Dogs with no previous kennel experience had higher nocturnal activity and UCCRs, and showed less body shaking, than dogs with previous kennel experience. Overall, sheltered dogs also showed less body shaking during the first night. The number of dogs showing paw lifting decreased over days. Age class and sex effected only few activity behaviours. Shelter dogs significantly lost body weight after 12 days in the shelter compared to the moment of intake. Shelter dogs had disrupted nocturnal resting patterns and UCCRs compared to pet dogs and seem to partly adapt to the shelter environment after two weeks. Sensor-supported identification of nocturnal activity can be a useful additional tool for welfare assessments in animal shelters.
Consumption of aspartame and other artificial sweeteners and risk of cancer in the Spanish multicase‐control study (MCC‐Spain)

Use of artificial sweeteners (AS) such as aspartame, cyclamate, saccharin and sucralose is widespread. We evaluated the association of use of aspartame and other AS with cancer. In total 1881 colorectal, 1510 breast, 972 prostate and 351 stomach cancer and 109 chronic lymphocytic leukaemia (CLL) cases and 3629 population controls from the Spanish Multicase‐Control (MCC‐Spain) study were recruited (2008‐2013). The consumption of AS, from table‐top sweeteners and artificially sweetened beverages, was assessed through a self‐administered and validated food frequency questionnaire (FFQ). Sex‐specific quartiles among controls were determined to compare moderate consumers (
Teaching Person-Centered Care and Interprofessional Collaboration through a Virtual Mental Health World Café: A Mixed Methods IPE Pilot Project

Abstract The purpose of this convergent mixed methods interprofessional education (IPE) pilot project was to help health profession students gain valuable insight about the experiences of people living with mental illness, to help them have a better understanding of person-centered care and have greater knowledge about the importance of interprofessional collaboration. A developmental workgroup which consisted of mental health consumers, four interdisciplinary students, and our team developed and implemented a virtual Mental Health World Café IPE event. Twelve other students attended the World Café event. A paired sample t-test was used to examine group differences between pre- and post-test scores for the Interprofessional Socialization and Valuing Scale and the Texas AHEC Survey measures among the four student leaders and the 12 student participants of the virtual Mental Health World Cafe. We conducted individual interviews with the four student leaders and collected reflective journals from the 12 students who attended the World Café event. We examined to what extent the statistically significant quantitative results supported the qualitative results separately for the student leaders and for the student participants of the virtual World Café. We also examined how both the quantitative and qualitative findings aligned with the key components of the Patient-Centered Care in Interprofessional Collaborative Practice Model. While the project allowed the students to reflect upon how they may apply the principles of person-centered care and interprofessional collaboration, the impact of the consumers on the student’s experiences was profound and resulted in widespread engagement of the students who attended the event.
Coupled behavior informatics: modeling, analysis and learning

Behavior refers to the action or property of an actor, entity or otherwise, to situations or stimuli in its environment. The in-depth analysis of behavior has been increasingly recognized as a crucial means for understanding and disclosing interior driving forces and intrinsic cause-effects on business and social applications, including web community analysis, counterterrorism, fraud detection and customer relationship management, etc. Currently, behavior modeling and analysis have been extensively investigated by researchers in different disciplines, e.g. psychology, economics, mathematics, engineering and information science. From those diverse perspectives, there are widespread and long-standing explorations on behavior studies, such as behavior recognition, reasoning about action, interactive process modeling, multivariate time series analysis, and outlier mining of trading behaviors. All the above emerging methods however suffer from the following common issues and problems to different extents: (1) Existing behavior modeling approaches have too many styles and forms according to distinct situations, which is troublesome for cross-discipline researchers to follow. (2) Traditional behavior analysis relies on implicit behavior and explicit business appearance, often leading to ineffective and limited understanding on business and social activities. (3) Complex coupling relationships between behaviors are often ignored or only weakly addressed, which fails to provide a complete understanding of the underlying problems and their comprehensive solutions. (4) Current research usually overlooks the checking of behavior interactions, which weakens the soundness and robustness of models built for complex be-