Miracle-dz/UniFAR-FTUs huggingface dataset:
DRIVING MECHANISM AND ONSET CONDITION OF A CONFINED ERUPTION

We study a confined eruption accompanied by an M1.1 flare in solar active region (AR) NOAA 10767 on 2005 May 27, where a pre-eruptive magnetic flux rope was reported in a nonlinear force-free field (NLFFF) extrapolation. The observations show a strong writhing motion of the erupting structure, suggesting that a flux rope was indeed present and converted some of its twist into writhe in the course of the eruption. Using the NLFFF extrapolation, we calculate the twist of the pre-eruptive flux rope and find that it is in very good agreement with thresholds of the helical kink instability found in numerical simulations. We conclude that the activation and rise of the flux rope were triggered and driven by the instability. Using a potential field extrapolation, we also estimate the height distribution of the decay index of the external magnetic field in the AR 1 hr prior to the eruption. We find that the decay index stays below the threshold for the torus instability for a significant height range above the erupting flux rope. This provides a possible explanation for the confinement of the eruption to the low corona.
Computer-aided classification of colorectal segments during colonoscopy: a deep learning approach based on images of a magnetic endoscopic positioning device

Abstract Objective Assessment of the anatomical colorectal segment of polyps during colonoscopy is important for treatment and follow-up strategies, but is largely operator dependent. This feasibility study aimed to assess whether, using images of a magnetic endoscope imaging (MEI) positioning device, a deep learning approach can be useful to objectively divide the colorectum into anatomical segments. Methods Models based on the VGG-16 based convolutional neural network architecture were developed to classify the colorectum into anatomical segments. These models were pre-trained on ImageNet data and further trained using prospectively collected data of the POLAR study in which endoscopists were using MEI (3930 still images and 90,151 video frames). Five-fold cross validation with multiple runs was used to evaluate the overall diagnostic accuracies of the models for colorectal segment classification (divided into a 5-class and 2-class colorectal segment division). The colorectal segment assignment by endoscopists was used as the reference standard. Results For the 5-class colorectal segment division, the best performing model correctly classified the colorectal segment in 753 of the 1196 polyps, corresponding to an overall accuracy of 63%, sensitivity of 63%, specificity of 89% and kappa of 0.47. For the 2-class colorectal segment division, 1112 of the 1196 polyps were correctly classified, corresponding to an accuracy of 93%, sensitivity of 93%, specificity of 90% and kappa of 0.82. Conclusion The diagnostic performance of a deep learning approach for colorectal segment classification based on images of a MEI device is yet suboptimal (clinicaltrials.gov: NCT03822390).
Evaluation of different anthropometric indices for predicting metabolic syndrome.

OBJECTIVE Metabolic syndrome is a condition characterized by metabolic abnormalities. Its overall prevalence increases with age, in turn resulting in a substantial burden of disease all around the world. The aim of this study is to evaluate the efficacy of several anthropometric indices for predicting metabolic syndrome among the elderly people. SUBJECTS AND METHODS This study was conducted on 348 elderly people aged 65 and over, including those who were diagnosed with metabolic syndrome based on the National Cholesterol Education Program's Adult Treatment Panel III criteria and those who did not suffer from metabolic syndrome. A trained dietitian performed body weight, height, waist circumference, and hip circumference measurements. Furthermore, body mass index, waist-hip ratio, waist-height ratio, conicity index, abdominal volume index, body shape index, and body roundness index values were measured. The receiver operating characteristic (ROC) curve was applied to assess the capability of these indices to predict metabolic syndrome. RESULTS: Of the 348 subjects recruited, 56.0% had metabolic syndrome. Body Roundness Index had the largest area under the curve for predicting metabolic syndrome in both males and females (0.678 and 0.645, respectively), followed by abdominal volume index (0.673 and 0.626, respectively) and waist circumference (0.672 and 0.626, respectively). CONCLUSIONS Body roundness index was more effective compared to the other seven indices for predicting metabolic syndrome in the elderly population in Turkey.
Luminance effects on pupil dilation in speech-in-noise recognition

There is an increasing interest in the field of audiology and speech communication to measure the effort that it takes to listen in noisy environments, with obvious implications for populations suffering from hearing loss. Pupillometry offers one avenue to make progress in this enterprise but important methodological questions remain to be addressed before such tools can serve practical applications. Typically, cocktail-party situations may occur in less-than-ideal lighting conditions, e.g. a pub or a restaurant, and it is unclear how robust pupil dynamics are to luminance changes. In this study, we first used a well-known paradigm where sentences were presented at different signal-to-noise ratios (SNR), all conducive of good intelligibility. This enabled us to replicate findings, e.g. a larger and later peak pupil dilation (PPD) at adverse SNR, or when the sentences were misunderstood, and to investigate the dependency of the PPD on sentence duration. A second experiment reiterated two of the SNR levels, 0 and +14 dB, but measured at 0, 75, and 220 lux. The results showed that the impact of luminance on the SNR effect was non-monotonic (sub-optimal in darkness or in bright light), and as such, there is no trivial way to derive pupillary metrics that are robust to differences in background light, posing considerable constraints for applications of pupillometry in daily life. Our findings raise an under-examined but crucial issue when designing and understanding listening effort studies using pupillometry, and offer important insights to future clinical application of pupillometry across sites.
A novel anti-NGF PEGylated Fab’ provides analgesia with lower risk of adverse effects

ABSTRACT Nerve growth factor (NGF) has emerged as a key driver of pain perception in several chronic pain conditions, including osteoarthritis (OA), and plays an important role in the generation and survival of neurons. Although anti-NGF antibodies improve pain control and physical function in patients with clinical chronic pain conditions, anti-NGF IgGs are associated with safety concerns such as effects on fetal and postnatal development and the risk of rapidly progressive osteoarthritis. To overcome these drawbacks, we generated a novel anti-NGF PEGylated Fab’ antibody. The anti-NGF PEGylated Fab’ showed specific binding to and biological inhibitory activity against NGF, and analgesic effects in adjuvant-induced arthritis model mice in a similar manner to an anti-NGF IgG. In collagen-induced arthritis model mice, the anti-NGF PEGylated Fab’ showed higher accumulation in inflamed foot pads than the anti-NGF IgG. In pregnant rats and non-human primates, the anti-NGF PEGylated Fab’ was undetectable in fetuses, while the anti-NGF IgG was detected and caused abnormal postnatal development. The PEGylated Fab’ and IgG also differed in their ability to form immune complexes in vitro. Additionally, while both PEGylated Fab’ and IgG showed analgesic effects in sodium monoiodoacetate-induced arthritic model rats, their effects on edema were surprisingly quite different. While the anti-NGF IgG promoted edema over time, the anti-NGF PEGylated Fab’ did not. The anti-NGF PEGylated Fab’ (ASP6294) may thus be a potential therapeutic candidate with lower risk of adverse effects for various diseases in which NGF is involved such as OA and chronic back pain.
Ethnicity in polycystic ovary syndrome

Abstract Polycystic ovary syndrome (PCOS) is the commonest gynecological endocrinopathy. Little is known about the exact etiopathogenesis and cardiometabolic mortality and morbidity in women with PCOS. PCOS is beyond the cosmetic concerns of an adolescent and fertility concerns of an adult and can cause serious unhealthy consequences in perimenopausal and postmenopausal age. This area needs to be assessed and addressed since the majority of these patients are lost to follow-up after completion of their families. Good evidence suggests that there are significant racial and ethnic differences in prevalence, insulin resistance, metabolic syndrome, hyperandrogenemia and the related cardiometabolic risk in women with PCOS.
Shared governance council to engage advanced practice registered nurses in a hospital setting

ABSTRACT Background: Health care organizations use advanced practice registered nurses (APRNs) to expand patient access and support high-quality care. However, turnover, often exacerbated by inadequate engagement, has steep financial and experiential costs. Local problem: The project site, a large urban academic institution with quaternary care capabilities, employs more than 300 APRNs to provide patient care. Due to variations in hiring entity, leadership structure, and organizational visibility, efforts to maintain APRN engagement were complex. In addition, inconsistencies in standardization of clinical, credentialing, and privileging procedures created organizational risk. Methods: Quality improvement principles informed the implementation of a shared governance council for APRNs that included nurse practitioners and certified registered nurse anesthetists. Data were collected pre and postintervention using validated engagement questions. Intervention: Implementation of a shared governance council to support the organizational engagement of APRNs through decisional involvement in professional practice issues. Results: Analysis included the percentage of change in aggregate scores and the Wilcoxon rank-sum test to obtain p values of the 2 independent samples. There was an 8.9% increase in aggregate postintervention scores and statistical improvement in measures of quality improvement involvement. Conclusion: Participation in the shared governance council increased APRN engagement through enhanced opportunities to communicate professional and clinical practice issues, decisional involvement, and collaboration. Statistically significant improvements in quality improvement involvement values potentially affirm the council's role in facilitating work environment improvements. Potential long-term gains include improved job satisfaction, retention, and organizational cost savings.
Does exercise affect quality of life and participation of adolescents and adults with cerebral palsy: a systematic review

Abstract Purpose Investigate the effect of exercise for adults with cerebral palsy (CP) on quality of life, participation (attendance and involvement in life situations), functional mobility, pain, fatigue, mood, and self-efficacy. Methods A systematic review was completed. Twelve databases were searched from inception to August 2022 for studies including participants (≥16 years) with cerebral palsy, and that evaluated an exercise intervention. Two reviewers independently assessed eligibility, risk of bias, and extracted data. Results Seventeen studies (total n = 532) were included: 12 randomised control trials, four non-randomised trials, and one single case experimental design. Interventions studied were predominantly strength, aerobic or treadmill training, dance, and swimming. No study assessed participation, pain or mood. Of two studies that assessed quality of life, one reported a positive effect on an aspect of mental health immediately after the programme finished. All studies assessed functional mobility, but only one reported a positive effect. One study assessed self-efficacy and found no effect, and another assessed fatigue and reported conflicting results. Conclusions The effect of exercise for adults with CP, on outcomes that adults report as important to them – quality of life, participation, pain, mood, and fatigue – are unknown. IMPLICATIONS FOR REHABILITATION To address outcomes important to adults with cerebral palsy (CP), it is important to understand how exercise affects participation and quality of life. All modes of exercise reviewed appear safe for adults with CP and choice should be based on the client’s preferences, access to services, and convenience. Addressing any needed accommodations in the environment and context is likely more important than exercise prescription parameters when tailoring exercise to meet the needs of adults with CP and sustain participation.
Regional Characteristics of the Northern Hemisphere Wintertime Circulation: A Comparison of the Simulation of a GFDL General Circulation Model with Observations

Abstract The hemispheric distributions of a selected set of temporal mean, variance and covariance statistics produced by a general circulation model developed at the Geophysical Fluid Dynamics Laboratory are compared with observations. The fields presented include 1) the seasonally averaged 300 mb geopotential height and zonal wind speed, sea level pressure and 500 mb vertical velocity; 2) the root-mean-squares of 500 and 1000 mb heights, and of 850 mb temperature; 3) the correlation coefficient between the 1000 and 500 mb heights, and 4) the horizontal and vertical transports of heat by transient eddies in the lower troposphere, and the horizontal eddy transports of momentum and potential vorticity near the tropopause. The partitioning of the variance of 500 mb height according to fluctuations of different temporal and spatial scales is examined. By making use of time filters which retain fluctuations with periods between 2.5 and 6 days, the characteristics of synoptic-scale disturbances appearing in th.
Ectoine gel transdermal formulation as a novel therapeutic approach in melanoma using 3D printed microneedles

Abstract A 7%w/w ectoine formula, from natural source, is formulated to reduce melanomagenesis, enhance penetration by 3D printed microneedles (MNs), with specified length, diameter and tip to ensure painless effect. Ectoine gel formulations were prepared using Carbopol 940 and Pluronic (F127). The effect of the polymers on pH, viscosity, spreadability, and the in vitro, ex vivo release profiles was obtained. The physiochemical investigation showed uniform gel formulations. The formulations’ in vitro and ex vivo drug release displayed a controllable drug release pattern, reaching 63.7–96% and 73–94.7% after 24 h. The permeation study of the in vitro and ex vivo release revealed that the drug release from gels followed diffusion mechanism. The selected formula was used, 3D printed MN array was applied to treat melanoma. Male rats were used for induction of melanoma using 0.5% of 7,12-dimethylbenz[a]anthracene three times weekly for 12 weeks, histopathology was applied to ensure development of carcinoma then rats were treated using the selected formula. Following treatment for continuous 6 weeks, histopathology showed a change in anatomy of skin, which started to return to its normal structure. The anti-melanogenesis activity of optimum formula of ectoine gel, enhanced by 3D printed MN, was found to be effective in reducing the severity of skin cancer reinforcing the efficacy of the promising treatment.
New predictive model of the touchdown times in a high level 110 m hurdles

The present study aimed to establish a more robust, reliable statistical model of touchdown times based on the data of elite 110 m hurdlers to precisely predict performance based on touchdown times. We obtained 151 data (race time: 13.65 ± 0.33 s, range of race time: 12.91 s– 14.47 s) from several previous studies. Regression equations were developed to predict each touchdown time (times from the start signal to the instants of the leading leg landing after clearing 1st to 10th hurdles) from the race time. To avoid overtraining for each regression equation, data were split into training and testing data sets in accordance with a leave–one–out cross-validation. From the results of cross-validation, the agreement and generalization were compared between the present study model and the existing model. As a result, the proposed predictive equations showed a good agreement and generalization (R2 = 0.527–0.981, MSE = 0.0015–0.0028, MAE = 0.019–0.033) compared to that of existing equations (R2 = 0.481–0.979, MSE = 0.0017–0.0039, MAE = 0.034–0.063). Therefore, it can be assumed that the proposed predictive equations are a more robust, reliable model than the existing model. The touchdown times needed for coaches and elite hurdlers to set their target records will be accurately understood using the model of this study. Therefore, this study model would help to improve training interventions and race evaluations.
Residual Lung Abnormalities after COVID-19 Hospitalization: Interim Analysis of the UKILD Post–COVID-19 Study

Rationale Shared symptoms and genetic architecture between coronavirus disease (COVID-19) and lung fibrosis suggest severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection may lead to progressive lung damage. Objectives The UK Interstitial Lung Disease Consortium (UKILD) post–COVID-19 study interim analysis was planned to estimate the prevalence of residual lung abnormalities in people hospitalized with COVID-19 on the basis of risk strata. Methods The PHOSP–COVID-19 (Post-Hospitalization COVID-19) study was used to capture routine and research follow-up within 240 days from discharge. Thoracic computed tomography linked by PHOSP–COVID-19 identifiers was scored for the percentage of residual lung abnormalities (ground-glass opacities and reticulations). Risk factors in linked computed tomography were estimated with Bayesian binomial regression, and risk strata were generated. Numbers within strata were used to estimate posthospitalization prevalence using Bayesian binomial distributions. Sensitivity analysis was restricted to participants with protocol-driven research follow-up. Measurements and Main Results The interim cohort comprised 3,700 people. Of 209 subjects with linked computed tomography (median, 119 d; interquartile range, 83–155), 166 people (79.4%) had more than 10% involvement of residual lung abnormalities. Risk factors included abnormal chest X-ray (risk ratio [RR], 1.21; 95% credible interval [CrI], 1.05–1.40), percent predicted DlCO less than 80% (RR, 1.25; 95% CrI, 1.00–1.56), and severe admission requiring ventilation support (RR, 1.27; 95% CrI, 1.07–1.55). In the remaining 3,491 people, moderate to very high risk of residual lung abnormalities was classified at 7.8%, and posthospitalization prevalence was estimated at 8.5% (95% CrI, 7.6–9.5), rising to 11.7% (95% CrI, 10.3–13.1) in the sensitivity analysis. Conclusions Residual lung abnormalities were estimated in up to 11% of people discharged after COVID-19–related hospitalization. Health services should monitor at-risk individuals to elucidate long-term functional implications.
Frequency of Hawking Radiation of Black Holes

In the present research work, we calculate the frequencies of Hawking radiations emitted from different test black holes existing in X-ray binaries (XRBs) and active galactic nuclei (AGN) by utilizing the proposed formula for the frequency of Hawking radiation f=8.037x1033kg/M(HZ)and show that these frequencies of Hawking radiations may be the components of electromagnetic spectrum and gravitational waves. We also extend this work to convert the frequency of Hawking radiation in terms of the mass of the sun (Mo)and then of Chandrasekhar limit (Mch), which is the largest unit of mass.
The Sensitivity of WRF Daily Summertime Simulations over West Africa to Alternative Parameterizations. Part I: African Wave Circulation

AbstractThe performance of the NCAR Weather Research and Forecasting Model (WRF) as a West African regional-atmospheric model is evaluated. The study tests the sensitivity of WRF-simulated vorticity maxima associated with African easterly waves to 64 combinations of alternative parameterizations in a series of simulations in September. In all, 104 simulations of 12-day duration during 11 consecutive years are examined. The 64 combinations combine WRF parameterizations of cumulus convection, radiation transfer, surface hydrology, and PBL physics. Simulated daily and mean circulation results are validated against NASA’s Modern-Era Retrospective Analysis for Research and Applications (MERRA) and NCEP/Department of Energy Global Reanalysis 2. Precipitation is considered in a second part of this two-part paper. A wide range of 700-hPa vorticity validation scores demonstrates the influence of alternative parameterizations. The best WRF performers achieve correlations against reanalysis of 0.40–0.60 and realisti.
Chlorogenic Acid Inhibits Epithelial-Mesenchymal Transition and Invasion of Breast Cancer by Down-Regulating LRP6

Epithelial-mesenchymal transition (EMT) is a crucial biologic process for breast cancer metastasis, and inhibition of EMT could be an effective approach to suppress metastatic potential of mammary cancer. High expression of low-density lipoprotein receptor-related protein 6 (LRP6) is usually observed in breast carcinoma and predicts poor prognosis. In the present study, we investigated whether chlorogenic acid (CA) can inhibit the EMT of breast cancer cells and underlying molecular mechanism. We found that CA treatment transformed MCF-7 cell morphology from spindle shape (mesenchymal phenotype) to spherical shape (epithelial phenotype). CA clearly increased epithelial biomarkers’ expression (E-cadherin and ZO-1) but decreased mesenchymal proteins’ expression (ZEB1, N-cadherin, vimentin, snail, and slug). In addition, CA attenuated MMP-2 and MMP-9 activities and inhibited cell migration and invasion. CA downregulated the expression of LRP6 in MCF-7 cells. Knockdown LRP6 with siRNA repressed cell mobility and invasion, wheras overexpression of LRP6 promoted EMT and antagonized the EMT inhibitory effect of CA on MCF-7 cells. Furthermore, CA directly interacted with Wnt/β-catenin signaling coreceptor LRP6 and reduced LRP6, p-LRP6, and β-catenin expression levels in MCF-7 cells. In vivo study revealed that CA notably reduced tumor volume and tumor weight. CA decreased the expression of LRP6, N-cadherin, ZEB1, vimentin, MMP2, MMP9, and increased the expression of E-cadherin and ZO-1. In conclusion, CA inhibited EMT and invasion of breast cancer by targeting LRP6. SIGNIFICANCE STATEMENT CA, the familiar polyphenol compound in traditional Chinese medicine, repressed EMT and weakened cellular mobility and invasion in MCF-7 cells. The mechanism studies demonstrated that CA could inhibit EMT and invasion of MCF-7 cells via targeting LRP6. Additionally, CA restrained tumor growth and xenograft tumor EMT in vivo. The EMT inhibitory property of CA warrants further studies of CA as a drug candidate for the therapy of metastatic breast carcinoma.
New Advances in the Knowledge of Elemental Enthesis Lesions: Doppler, Erosion, and Thickness

The entheses are more than a point of anatomical attachment for tendons, ligaments, joint capsules and fascia to bones; its involvement in the pathophysiology of spondyloarthritis (SpA) and psoriatic arthritis (PsA) is the cornerstone of these diseases. In 1971, the relevance of the enthesis as the primary pathological site of seronegative SpA was clearly defined.1.