Miracle-dz/UniFAR-FTUs huggingface dataset:
Exploring Multi Feature Optimization for Summarizing Clinical Trial Descriptions

Documenting Clinical Trial Descriptions of patients can help doctors with diagnostics and treatment plans and can be used for future reference. However, with the rapid growth of population, manually checking all previous files of a patient is not feasible. We address this challenge by providing summaries of clinical trial descriptions. We present a framework for automatically summarizing Clinical Trial Descriptions, which takes advantage of different features in semantic and syntactic space. We propose a multi objective optimization technique which uses position and similarity of the sentences. The similarity is established based on TF-IDF and WMD. We evaluate the proposed method on clinical trial dataset, and compare the results against human gold standard summaries using ROUGE metrics. Our approach is unsupervised in nature which has an advantage over supervised models in the advent of new diseases where a large quantity of quality data is not available. We provide a detailed ablation study to show the contribution of each feature in our approach and release our code on GitHub.1
Genetic characterization of late blight resistance in Solanum pimpinellifolium accession PI 270442

One of the most destructive foliar diseases of the cultivated tomato (Solanum lycopersicum) is late blight (LB), caused by the oomycete Phytophthora infestans. Due to the limited number of commercial tomato cultivars with resistance to this disease, control is mainly through cultural practices and heavy use of fungicides. The appearance of fungicide-resistant P. infestans genotypes, however, necessitates identification of new genetic sources of host resistance to the disease and subsequent breeding of new resistant cultivars. Several new sources of resistance to tomato LB were identified in a recent screening of the tomato related wild species S. pimpinellifolium. In the present study, we examined the genetic basis of LB resistance in accession PI 270442, through parent-offspring correlation analysis, generation means analysis, and analysis of response to selection, using populations derived from crosses with a LB-susceptible tomato breeding line. 14 Matthew T. Sullenberger and Majid R. Foolad Across experiments, estimates of heritability (h) for LB resistance ranged from 0.56 – 0.86, suggesting the heritable nature of this resistance and possibility of effectively transferring LB resistance from PI 270442 to the cultivated tomato genetic background through phenotypic selection and traditional backcross breeding. Genetic mapping studies are currently underway to identify the associated molecular markers for LB resistance in PI 270442.
Fast-D: When Non-Smoothing Color Feature Meets Moving Object Detection in Real-Time

The moving object detection refers to the detection of physical moving objects from a video, which is applied in video surveillance, object recognition, object counting, human-computer interaction, and so on. Moreover, nowadays, real-time moving object detection is used as services in the cloud, edge, and fog computing. However, the existing methods do not meet the trade-off between accuracy and complexity. To address these issues, we present a background subtraction-based moving object detection method, called Fast-D. In this paper, we look at the ‘non-smoothing color feature’ to make the moving object detection more robust in real-time. Each color feature is given equal significance during the classification of a pixel. Background model and threshold are initialized for each pixel. And then, the background model and threshold are updated dynamically when there are changes in the background of the video. Adaptive post-processing is considered to discard salt and pepper noise and fill holes in the detected moving object silhouettes. The evaluation of our proposed method on four complex datasets exhibits the significance.
Notes on Some South American Species of Scirtes Illiger, 1807 (Coleoptera: Scirtidae)

Abstract. The species of the genus Scirtes Illiger, 1807 (Coleoptera: Scirtidae) from Argentina are revised. Seven species are recognized: S. adustus Boheman, 1858, S. caraguata sp. nov., S. dentatus sp. nov., S. diversenotatus Pic, 1930, S. gallus sp. nov., S. helicoidalis sp. nov., and S. rufobinotatus Pic, 1922. S. postimpressus Pic, 1922 is proposed as a junior synonym of Scirtes rufobinotatus. Illustrations of dorsal habitus, male and female genitalia, and other diagnostic features are provided along with a key to the species.
Temperature influence on postovulatory follicle degeneration in Atlantic menhaden, Brevoortia tyrannus

Department of Zoology. Box 76 J7 North Carolina State University Raleigh. North Carolina 27695-7617 Present address: The institute for Fishery Resource Biology Florida State University and Southeast Fisheries Science Center National Marine Fisheries Service. NOAA 3500 Delwood Beach Road. Panama City. Florida 32408-7403 1983). Eggs have been collected between the 15° and 20°C surface isotherms in the mid-Atlantic Bight (Kendall and Reintjes, 1974). We wished to examine differences in postovulatory follicle duration and age at stage due to temperature in Atlantic menhaden. As a preliminary step to future estimation of spawning frequencies, our objective was to characterize postovulatory follicle degeneration and validate postovulatory follicle duration. for Atlantic menhaden induced to spawn at different temperatures in the laboratory.
Using Data Mining to Find Patterns Related to Interest and Work Readiness of Students in the Culinary Diploma Program as Indonesian Food Cooks

Several studies have shown that the expertise of young chefs graduating from culinary diploma programs in Indonesia who specialize in Indonesian food has not been able to demonstrate their expertise according to stakeholder needs. The implementation of the curriculum in certain subjects is expected to have an impact on the growing interest of students to take the course and will also affect work readiness in their fields. This study uses data mining techniques to process data obtained from closed instruments distributed to 60 students from 6 universities in Indonesia. As a result, there are some interesting patterns between curriculum management and the interests of young chefs that can be extracted from the data obtained.
LayART: Generating indoor layout using ARCore Transformations

Reconstructing an indoor scene and generating a layout/floor plan in 3D or 2D is a widely known problem. Quite a few algorithms have been proposed in the literature recently. However, most of the existing methods either use RGB-D images, thus requiring a depth camera, or depend on panoramic photos with the assumption that there is little to no occlusion in the rooms. In this work, we proposed generation of layout using an RGB image captured using a simple mobile phone camera. We take advantage of Simultaneous Localization and Mapping (SLAM) to assess the 3D transformations required for layout generation. SLAM technology is built-in in recent mobile libraries such as ARCore by Google. Hence, the proposed method is fast and efficient, while giving the user freedom to generate layout by simply taking a few conventional photos, rather than relying on specialized depth hardware or occlusion-free panoramic photos.
Neonatal Developmental Venous Anomalies: Clinicoradiologic Characterization and Follow-Up

BACKGROUND AND PURPOSE: Although developmental venous anomalies have been frequently studied in adults and occasionally in children, data regarding these entities are scarce in neonates. We aimed to characterize clinical and neuroimaging features of neonatal developmental venous anomalies and to evaluate any association between MR imaging abnormalities in their drainage territory and corresponding angioarchitectural features. MATERIALS AND METHODS: We reviewed parenchymal abnormalities and angioarchitectural features of 41 neonates with developmental venous anomalies (20 males; mean corrected age, 39.9 weeks) selected through a radiology report text search from 2135 neonates who underwent brain MR imaging between 2008 and 2019. Fetal and longitudinal MR images were also reviewed. Neurologic outcomes were collected. Statistics were performed using χ2, Fisher exact, Mann-Whitney U, or t tests corrected for multiple comparisons. RESULTS: Developmental venous anomalies were detected in 1.9% of neonatal scans. These were complicated by parenchymal/ventricular abnormalities in 15/41 cases (36.6%), improving at last follow-up in 8/10 (80%), with normal neurologic outcome in 9/14 (64.2%). Multiple collectors (P = .008) and larger collector caliber (P < .001) were significantly more frequent in complicated developmental venous anomalies. At a patient level, multiplicity (P = .002) was significantly associated with the presence of ≥1 complicated developmental venous anomaly. Retrospective fetal detection was possible in 3/11 subjects (27.2%). CONCLUSIONS: One-third of neonatal developmental venous anomalies may be complicated by parenchymal abnormalities, especially with multiple and larger collectors. Neuroimaging and neurologic outcomes were favorable in most cases, suggesting a benign, self-limited nature of these vascular anomalies. A congenital origin could be confirmed in one-quarter of cases with available fetal MR imaging.
First Report of Alternaria Black Spot of Rose Caused by Alternaria alternata in Pakistan

In Pakistan, roses are commercially valuable as ornamentals and for perfumes essential oils, rose syrup, and herbal tea. During 2015-2016, circular to oval black spots (2 to 3 mm in diameter) were observed on roses in the cities of Islamabad and Rawalpindi. A total of 35 symptomatic leaves were surface sterilized with 1% sodium hypochlorite for 2 min and then rinsed three times with sterile distilled water. Excised segments (3 mm2) of surface sterilized tissue were transferred to potato dextrose agar (PDA) and incubated at 25 ± 2°C. After 5 days, white colonies developed from 25 samples and later turned black or golden brown. The conidia were borne singly or in short chains and were obpyriform to obclavate, 10-40 x 6.2-17.60 µm with 0 to 3 longitudinal and 2 to 6 transverse septa. The morphological characters matched those of Alternaria alternata (Fr.) Keissl (Simmons 2007). For confirmation of pathogenicity, three asymptomatic mature rose leaves were surface sterilized with 1% sodium hypochlorite and the.
Can domestic pigeon be a potential carrier of zoonotic Salmonella?

Abstract Salmonellosis is one of the most important bacterial diseases in pigeons. This study aimed to estimate the prevalence of Salmonella spp. in domestic pigeons (Columba livia f. domestica) in Poland, its antimicrobial susceptibility (both phenotypic and genotypic), and its capability for biofilm formation. The presence of selected virulence genes, nucleotide homology of selected genes, and susceptibility to bacteriophages were investigated as well. From the 585 pigeons tested, 5.47% turned out positive. All isolated strains were recognized as Salmonella enterica ser. Typhimurium. The asymptomatic pigeons were carriers of 37.5% of the isolates. The dominant variants were as follows: 1,4,[5],12,:i:1,2 (53.13%) and 1,4,[5],12,:‐:‐ (31.25%). Most of the strains analysed showed the ability to produce biofilm after 24 and 48 hr of incubation (59.38% and 53.13%, respectively). Over 90% of the strains were confirmed for lpfA, agafA, invA, sivH, and avrA virulence genes. Also, of the thirteen antimicrobial susceptibility genes, the following were confirmed: sul1, tet(A), blaTEM‐1 , floR, strA, and strB. The most common were the strB (18%) and tet(A) (12%) genes that are responsible for coding resistance to aminoglycosides and tetracyclines, respectively. Most of the strains were phenotypically resistant to oxytetracycline (46.88%), neomycin (53.13%) and tylosin (100%). The susceptibility of the investigated Salmonella strains to the bacteriophages was between 33% and 100%. MLST, PCR MP and ERIC PCR analyses indicated a very high genetic similarity of the investigated strains (over 99%). Results of our study indicate that Salmonella enterica ser. Typhimurium is still an important agent in domestic pigeons and that its antimicrobial resistance increases. Alarming is also the confirmation of a single‐phase variant 1,4,[5],12:i,‐, which could have increased virulence and multi‐drug resistance encoded on the plasmid. Most importantly, however, such strains have been isolated from humans with clinical symptoms of Salmonella infection.
Detection, Purification and Elucidation of Chemical Structure and Antiproliferative Activity of Taxol Produced by Penicillium chrysogenum

Penicillium chrysogenum has been reported as a potent taxol producer based on quantitative analysis by TLC and HPLC. The biosynthetic potency of taxol has been validated from PCR detection of rate-limiting genes of taxol synthesis such as taxadienesynthase and 10-de-acetylbaccatin III-O-acetyltransferase (DBAT), which catalyzes the immediate diterpenoid precursor of the taxol substance, as detected by PCR. Taxol production by P. chrysogenum was assessed by growing the fungus on different media. Potato dextrose broth (PDB) was shown to be the best medium for obtaining the higher amount of taxol (170 µg/L). A stepwise optimization of culture conditions necessary for production of higher amounts of taxol was investigated. The substance taxol was produced optimally after 18 d of incubation at 30 °C in PDB adjusted initially at pH 8.0 with shaking (120 rpm) (250 µg/L). The P. chrysogenum taxol was purified successfully by HPLC. Instrumental analyzes such as Fourier transform infrared spectroscopy (FTIR), ultraviolet (UV) spectroscopy, 1HNMR and 13C NMR approved the structural formula of taxol (C47H51NO14), as constructed by ChemDraw. The P. chrysogenum taxol showed promising anticancer activity.
Mean platelet volume in children with systemic lupus erythematosus

Background Platelets are heterogeneous in size, density, metabolic, functional, and biochemical properties. Mean platelet volume (MPV) is a measure of the average size of platelet in a blood sample. Aim We aimed to evaluate the mean platelet volume as a marker for disease activity in children with systemic lupus erythematosus. Materials and Methods This was a prospective case-control study, which included 50 patients with SLE and 50 age and sex, matched healthy controls. All subjects were subjected to history taking, physical examination and laboratory parameters in active and remission phases of the diseases. Results The MPV value in the SLE group was significantly higher than control group (9.6 ± 1.3 fL, 9.1 ± 0.57 fL, respectively, p = 0.04). There was a significant increase of weight, blood pressure, urea, creatinine, proteinuria, CRP, ESR, cholestrol, MPV values, SLEDAI-2K scores and significant decrease of HB, albumin, C3, mean platelet volume (MPC) in the active stage than in the remission stage. There was a significant negative correlation between MPV and MPC in active stage of the disease but the correlation was insignificant in remission stage. Conclusion MPV increased in active phase of patients with SLE and can be an easy, rapid, inexpensive and simple method to assess disease activity in children with SLE.
Discrepancies between Perceived and Physiological Fall Risks and Repeated Falls among Community-Dwelling Medicare Beneficiaries Aged 65 Years and Older

ABSTRACT Objectives This study examined the associations of discrepancies between perceived and physiological fall risks with repeated falls. Methods We analyzed the 2016 Medicare Current Beneficiary Survey of 2,487 Medicare beneficiaries aged ≥ 65 years with ≥ 1 fall. The outcome variable was repeated falls (≥ 2 falls), the key independent variable was a categorical variable of discrepancies between perceived (fear of falling) and physiological fall risks (physiological limitations), assessed using multivariate logistic regression. Results Among Medicare beneficiaries with ≥ 1 fall, 25.1% had low fear of falling but high physiological fall risk (Low Fear-High Physiological), 9.4% had high fear of falling but low physiological fall risk (High Fear-Low Physiological), 23.5% had low fear of falling and low physiological fall risks (Low Fear-Low Physiological), and 42.0% had high fear of falling and high physiological fall risks (High Fear-High Physiological). Having High Fear-High Physiological was associated with repeated falls (OR = 2.14; p < .001) compared to Low Fear-Low Physiological. Having Low Fear-High Physiological and High Fear-LowPhysiological were not associated with repeated falls. Conclusions Given that High Fear-High Physiological was associated with repeated falls and that many at-risk Medicare beneficiaries had High Fear-High Physiological, prevention efforts may consider targeting those most at-risk including Medicare beneficiaries with High Fear-High Physiological. Clinical Implications Assessing both perceived and physiological fall risks is clinically relevant, given it may inform targeted interventions for different at-risk Medicare beneficiaries among clinicians and other stakeholders.
Neurobiological origins of individual differences in mathematical ability

Mathematical ability is heritable and related to several genes expressing proteins in the brain. It is unknown, however, which intermediate neural phenotypes could explain how these genes relate to mathematical ability. Here, we examined genetic effects on cerebral cortical volume of 3–6-year-old children without mathematical training to predict mathematical ability in school at 7–9 years of age. To this end, we followed an exploration sample (n = 101) and an independent replication sample (n = 77). We found that ROBO1, a gene known to regulate prenatal growth of cerebral cortical layers, is associated with the volume of the right parietal cortex, a key region for quantity representation. Individual volume differences in this region predicted up to a fifth of the behavioral variance in mathematical ability. Our findings indicate that a fundamental genetic component of the quantity processing system is rooted in the early development of the parietal cortex.
Immune checkpoint inhibition therapy for advanced skin cancer in patients with concomitant hematological malignancy: a retrospective multicenter DeCOG study of 84 patients

Background Skin cancers are known for their strong immunogenicity, which may contribute to a high treatment efficacy of immune checkpoint inhibition (ICI). However, a considerable proportion of patients with skin cancer is immuno-compromised by concomitant diseases. Due to their previous exclusion from clinical trials, the ICI treatment efficacy is poorly investigated in these patients. The present study analyzed the ICI treatment outcome in advanced patients with skin cancer with a concomitant hematological malignancy. Methods This retrospective multicenter study included patients who were treated with ICI for locally advanced or metastatic melanoma (MM), cutaneous squamous cell carcinoma (cSCC), or Merkel cell carcinoma (MCC), and had a previous diagnosis of a hematological malignancy irrespective of disease activity or need of therapy at ICI treatment start. Comparator patient cohorts without concomitant hematological malignancy were extracted from the prospective multicenter skin cancer registry ADOREG. Treatment outcome was measured as best overall response, progression-free (PFS), and overall survival (OS). Results 84 patients (MM, n=52; cSCC, n=15; MCC, n=17) with concomitant hematological malignancy were identified at 20 skin cancer centers. The most frequent concomitant hematological malignancies were non-Hodgkin’s lymphoma (n=70), with chronic lymphocytic leukemia (n=32) being the largest entity. While 9 patients received ICI in an adjuvant setting, 75 patients were treated for advanced non-resectable disease (55 anti-PD-1; 8 anti-PD-L1; 5 anti-CTLA-4; 7 combinations). In the latter 75 patients, best objective response (complete response+partial response) was 28.0%, disease stabilization was 25.3%, and 38.6% showed progressive disease (PD). Subdivided by skin cancer entity, best objective response was 31.1% (MM), 26.7% (cSCC), and 18.8% (MCC). Median PFS was 8.4 months (MM), 4.0 months (cSCC), and 5.7 months (MCC). 1-year OS rates were 78.4% (MM), 65.8% (cSCC), and 47.4% (MCC). Comparison with respective ADOREG patient cohorts without hematological malignancy (n=392) revealed no relevant differences in ICI therapy outcome for MM and MCC, but a significantly reduced PFS for cSCC (p=0.002). Conclusions ICI therapy showed efficacy in advanced patients with skin cancer with a concomitant hematological malignancy. Compared with patients without hematological malignancy, the observed ICI therapy outcome was impaired in cSCC, but not in MM or MCC patients.
New Male Users of Lipid-Lowering Drugs for Primary Prevention of Cardiovascular Disease: The Impact of Treatment Persistence on Morbimortality. A Longitudinal Study

The objective of this study was to analyse persistence to lipid-lowering drug use for primary prevention of cardiovascular disease (CVD) in a new users cohort, to explore all-cause and cardiovascular related morbidity, comorbidity and mortality in this group and, finally, to study the relationship between persistence and morbimortality. We selected subjects who started lipid-lowering treatment for primary prevention of CVD between 1 January 2010 and 31 December 2017 (N = 1424), and classified them as treatment-persistent or -nonpersistent. Bivariate analyses were performed to compare sociodemographic and clinical variables, morbimortality and time to event between groups. The association between morbidities was explored using comorbidity network analysis. The effect of persistence was analysed using logistic regression and Cox survival analyses. Only 38.7% of users were persistent with treatment. Persistent and nonpersistent users had similar sociodemographic and clinical profiles, although differed in age, smoking status, and glycemia. Comorbidity networks revealed that the number of co-occurring diagnoses was higher in nonpersistent than persistent users. Adjusted analyses indicated a protective effect of treatment persistence, especially against major adverse cardiovascular events (MACE), but this effect was not statistically significant. Observational studies are crucial to characterize real-world effectiveness.