Miracle-dz/UniFAR-FTUs huggingface dataset:
The Diagnostic and Prognostic Significance of ARID1A and CD8+ Expression in Endometrial Hyperplasia and Endometrial Endometrioid Adenocarcinoma (Immunohistochemical study)

Background: Epigenetic driver mutations and tumor microenvironment could play an important and promising role in diagnosis, prognosis, and prediction of different endometrial lesions. Aim: To determine their putative diagnostic and prognostic value, this work analyzes the immunohistochemical (IHC) expression of ARID1A and CD8+ in endometrial hyperplasia (EH) and endometrioid endometrial adenocarcinoma (EEA). Material and methods: The 88 distinct endometrial lesions included in this retrospective study included (28) EH without atypia, (38) atypical EH (AEH), and (38) EEA. Clinicopathological characteristics and survival of examined cases were correlated with the IHC expression of ARID1A and CD8+. Results: ARID1A negative expression was significantly associated with EEA (46.64) and AEH (384), while its positivity was associated with EH without atypia cases (1884) (P<8.81). ARID1A showed 1884 specificity and 38.34 sensitivity for premalignant (AEH) and malignant lesions. When compared to normal endometrium and EH without atypia, the amount of intraepithelial and stromal CD8+ expression revealed a significant difference between the examined cases (P<8.81 and P<8.85, respectively). ARID1A loss and high CD8+ expression was shown to be significantly correlated (P<8.81). Longer disease-free and recurrence-free survival were linked to ARID1A loss and high CD8+ expression. There was no discernible relationship between tumor grade, histologic type, lympho-vascular invasion, lymph node metastasis, or FIGO stage and either ARID1A or CD8+. Conclusion: ARID1A can be a reliable diagnostic indicator for premalignant lesions. ARID1A and CD8+ can each independently indicate a patient's increased chance of living longer and serve as biomarkers for the effectiveness of immunotherapy.
Psychometric Properties of the Portuguese Adolescent Students’ Basic Psychological Needs at School Scale (ASBPNSS) and Evidence of Differential Associations With Indicators of Subjective Wellbeing

The study aimed to test the psychometric properties of a Portuguese adaptation of the Adolescent Students’ Basic Psychological Needs at School Scale (ASBPNSS). For this, we used data from a sample of eighth graders (N = 1648; Mage = 14.1 years; 46.9% girls) from Portugal. Cronbach alpha and omega coefficients showed the ASBPNSS subscales—autonomy, relatedness, and competence—were reliable. Confirmatory factor analysis (CFA) showed the hypothesized three-factor model fit the data well. Multi-group CFAs showed the ASBPNSS had scalar invariance across gender and students from different socioeconomic backgrounds. Finally, need satisfaction in school was positively correlated with positive affect and life satisfaction and negatively correlated with negative affect. These findings support the theoretical assumptions of Basic Psychological Needs Theory (BPNT), and particularly the assumption that basic needs are universally applicable. We conclude the ASBPNSS is a reliable and valid measure of basic need satisfaction at school in Portuguese adolescents.
Cervical Cancer Screening Status Among Women Living With HIV/AIDs in Malawi: A Cross-Sectional Study

Worldwide, cervical cancer (CC) is the fourth most common cancer among women. Approximately 90% of cervical cancer cases occur in resource limited countries. Malawi is one of the developing countries with the highest incidence (ASR 67.9 per 100,000) of cc and the highest number of deaths (ASR 51.5 per 100,000) from cervical cancer in the world. More than 80% of Malawian women diagnosed with CC are at the inoperable cancer stage and suffer from co-infection with HIV. The purpose of this situation-specific theory guided study was to examine the cervical cancer screening status and factors affecting the screening status among Malawian women living with HIV infection aged 18-50 from HIV support groups in Malawi. A two stage proportionate stratified cluster random sampling method was used to select 291 respondents. The findings indicated that the prevalence of cervical cancer screening rate was 27.8%; and women had a high knowledge level and had a positive attitude towards cervical cancer screening. Despite a high knowledge level and positive attitude regarding screening, the cervical cancer screening rate was still low. The factors independently associated with cervical cancer screening in HIV positive women were: employment, OR = 6.37 (95% CI: 1.32, 30.80), knowledge OR =1.11 (95% CI: 1.03, 1.20), attitude, OR = 1.43 (95% CI: 1.04, 1.97) and social support networks OR =6.8 (95% CI: 1.41, 32.76). Community-based interventions and culturally tailored health education messages which include common myths about cervical cancer, HIV, and screening are critical when designing interventions to promote cervical cancer screening uptake in Malawi.
Record of fossil leaves of Ziziphus and Lagerstroemia from Mahuadanr Valley, Jharkhand, India and their ecological implications

A study based on the fossil leaf assemblage collected from the Late Tertiary sediments of Mahuadanr Valley revealed the occurrence of two new extant species Ziziphus funiculosa (Rhamnaceae) and Lagerstroemia macrocarpa (Lythraceae) of the Dicotyledon in the area during Late Tertiary Period. Present day distribution of these modem comparable species of the fossils indicates that both the taxa presently distributed in the moist deciduous forests ofthe northeast India, central and south India, which suggests that such type offorest was flourishing in and around the fossil locality during the sedimentation.
Clonal Dissemination of Extended-Spectrum Cephalosporin-Resistant Enterobacterales between Dogs and Humans in Households and Animal Shelters of Romania

Faecal carriage of extended-spectrum cephalosporin-resistant (ESC-R) Enterobacterales in healthy pets is a concerning issue. This study aimed to determine the prevalence, genetic background, and potential for interspecies transmission of these bacteria between dogs and humans within the same household (HH) or shelter environment in Romania. Faecal samples (n = 263) collected from healthy dogs (n = 102), their owners (n = 32), as well as dogs (n = 110) and staff (n = 19) from dog shelters, were screened for ESC-R carriage. Clonal relatedness of canine and human Escherichia coli isolates was established using Fourier Transform Infrared Spectroscopy (FTIR), followed by Illumina WGS of selected isolates. The highest prevalence of ESC-R Enterobacterales faecal carriage was identified in staff working at dog shelters (78.9%), followed by dogs from households (44.11%), dog owners (43.7%), and dogs from shelters (27%). FTIR identified 15 clusters of closely related E. coli isolates, including dog and human isolates from the same environment. Co-carriage of ESC-R isolates in both the dog and owner was identified in 12 HHs (37.5%), with two HHs (6%) having both the owner and dog carrying isolates with identical FTIR spectra, phylogroup, resistance genes, and Inc plasmids. Major ExPEC lineages such as ST127, ST10, ST155, and ST88 were detected in human and dog isolates. Our study revealed a high prevalence of faecal ESC-R E. coli carriage in both dogs and humans from Romanian households and shelters, where bidirectional clonal transmission between humans and dogs is likely. Furthermore, we identified ESC-R Enterobacterales co-carriage in people and dogs sharing the same environment using FTIR, demonstrating its value in AMR surveillance for humans and animals.
Does Economic Globalisation Harm Climate? New Evidence from European Union

The issue of globalisation-induced greenhouse gas emissions is an ongoing topic and a major challenge to the EU climate goals of achieving non-zero emissions by 2050. In the light of this ongoing debate on the globalisation–environment nexus, the paper examines the impact of economic globalisation on climate in EU countries over the period 2000–2019 and provide some new empirical evidence. After applying the panel cointegration analysis and the Granger causality test, the dynamic panel analysis is performed for 26 EU countries using the Arellano–Bond estimator. For the policy perspective, the analysed sample of countries is grouped into two subpanels according to their level of development—EU countries with above-average and below-average GDP per capita. After testing the effects of different dimensions of economic globalisation and environmental taxes on GHG emissions, the results revealed the following: (1) Trade globalisation is detrimental to the climate, as trade openness significantly increases emissions in both country groups. Financial globalisation has a weaker impact and increases emissions only in below-average countries, suggesting that FDI inflows could be important for the transfer of green technologies when a country reaches higher development level. (2) Passenger transport reduces GHG emissions in both groups of countries, while FDI are beneficiary for the climate in above-average countries. (3) Environmental taxes as a proxy for environmental policy show statistically significant results, but with different outcomes in the two groups; they have a negative impact on emissions in countries that are below the GDP p/c average, indicating the shortcomings of the tax system in addressing climate change. (4) The total energy consumption increases emissions in both country groups and, thus, harms the climate. Therefore, despite the current unfavourable circumstances, EU countries should continue to expand the green economy, increase energy consumption from renewables, and develop low-carbon technologies that do not depend on imported fossil fuels.
Diagnosis of Fungal Keratitis in Low-Income Countries: Evaluation of Smear Microscopy, Culture, and In Vivo Confocal Microscopy in Nepal

Clinically diagnosing fungal keratitis (FK) is challenging; diagnosis can be assisted by investigations including in vivo confocal microscopy (IVCM), smear microscopy, and culture. The aim of this study was to estimate the sensitivity in detecting fungal keratitis (FK) using IVCM, smear microscopy, and culture in a setting with a high prevalence of FK. In this cross-sectional study nested within a prospective cohort study, consecutive microbial keratitis (MK) patients attending a tertiary-referral eye hospital in south-eastern Nepal between June 2019 and November 2020 were recruited. IVCM and corneal scrapes for smear microscopy and culture were performed using a standardised protocol. Smear microscopy was performed using potassium hydroxide (KOH), Gram stain, and calcofluor white. The primary outcomes were sensitivities with 95% confidence intervals [95% CI] for IVCM, smear microscopy and culture, and for each different microscopy stain independently, to detect FK compared to a composite referent. We enrolled 642 patients with MK; 468/642 (72.9%) were filamentous FK, 32/642 (5.0%) were bacterial keratitis and 64/642 (10.0%) were mixed bacterial-filamentous FK, with one yeast infection (0.16%). No organism was identified in 77/642 (12.0%). Smear microscopy had the highest sensitivity (90.7% [87.9–93.1%]), followed by IVCM (89.8% [86.9–92.3%]) and culture (75.7% [71.8–79.3%]). Of the three smear microscopy stains, KOH had the highest sensitivity (85.3% [81.9–88.4%]), followed by Gram stain (83.2% [79.7–86.4%]) and calcofluor white (79.1% [75.4–82.5%]). Smear microscopy and IVCM were the most sensitive tools for identifying FK in our cohort. In low-resource settings we recommend clinicians perform corneal scrapes for microscopy using KOH and Gram staining. Culture remains an important tool to diagnose bacterial infection, identify causative fungi and enable antimicrobial susceptibility testing.
INFLUENCE OF UREA TREATMENT AND SUPPLEMENTA-TION OF PROTEIN AND ENERGY SOURCES ON CELL WALL STRUCTURE AND ITS DIGESTIBILITY OF RICE OR SOYBEAN STRAW BASED DIETS.

This experiment was carried out to investigate the effects of urea treatment, amount and source of energy and protein supplementation on the intake, fiber fractions digestibility of rice or soybean straw based diets with sheep. Two supplemental energy sources (maize or molasses + maize) and three sources of protein (fish meal, soybean meal and urea) were used. Sixteen metabolism trials were conducted to evaluate the nutritive values of the following rations: g/kg in CP The results showed that, there were pronounced effect of urea treatment on the chemical composition of RS and SBS. The digestibility of DM, OM, CF, NDF, ADF, hemicelluloise, cellulose and ADL of TRS rations were higher (P<0.01) than URS rations. The digestibility of CF was higher (P<0.05) when adding FM (76.9) than adding SBM (75.0%) in TRS rations. Also, digestibility of CF, NDF and hemicellulose were higher (P<0.05) when feeding on molasses and maize than feeding on maize in TRS roughage. The effect of urea treatment on dry matter intake (DMI) and TDN value were higher (P<0.01) than untreated materials. The TDN value (%) of ration containing TRS with FM and maize was (59.87%) higher than the other RS rations. The TDN value (%) of TSBS with SBM and maize plus molasses was (54.01%)higher than the other SBS rations. The results showed that there were significant differences as the effect of the type of the roughage. The urea treatment with adding protein and carbohydrate source improved RS digestion more than SBS.
Le polytope des sous-espaces d'un espace affin fini

Le polytope des m-sous-espaces est defini comme l'enveloppe convexe des vecteurs caracteristiques de tous les sous-espaces de dimension m d'un espace affin fini. Le cas particulier du polytope des hyperplans a ete etudie par Maurras (1993) et Anglada et Maurras (2003), qui ont obtenu une description complete des facettes. Le polytope general des m-sous-espaces que nous considerons possede une structure plus complexe, notamment concernant les facettes. Neanmoins, nous etablissons dans cette these plusieurs familles de facettes. Nous caracterisons egalement completement le groupe des automorphismes du polytope ainsi que l'adjacence des sommets du polytope des m-sous-espaces. Un tangle est un ensemble d'hyperplans d'un espace affin contenant un hyperplan par classe d'hyperplans paralleles. Anglada et Maurras ont montre que les tangles definissent des facettes du polytope des hyperplans et que toutes les facettes de ce polytope proviennent de tangles. Nous tentons d'etablir une generalisation de ce resultat. Nous elaborons une classification des tangles en familles pour de petites dimensions d'espaces affins.
Robust stability analysis of predictive controller for systems with input nonlinearity

For system with Hammerstein nonlinearity and input saturation constraint, the two step model predictive control (TSMPC) technique is adopted. This paper considers the uncertainty in system matrix and input nonlinearity, and obtains some exponential stability conditions for this kind of system. Furthermore, the domain of attraction for this kind of system is discussed and the algorithm for designing the domain of attraction is given. The stability results are validated with a simulation example.
The uncertainty principle and quantum chaos

The conception of quantum chaos is described in some detail. The most striking feature of this novel phenomenon is that all the properties of classical dynamical chaos persist here but, typically, on the finite and different time scales only. The ultimate origin of such a universal quantum stability is in the fundamental uncertainty principle which makes discrete the phase space and, hence, the spectrum of bounded quantum motion. Reformulation of the ergodic theory, as a part of the general theory of dynamical systems, is briefly discussed.
The nature of large-scale turbulence in the Jovian atmosphere

THE NATURE OF LARGE-SCALE TURBULENCE IN THE JOVIAN ATMOSPHERE 00 The energetics and spectral characteristics of quasi-geostrophic turbulence in Jupiter's atmosphere are examined using sequences of Voyager images and infrared temperature soundings. Using global wind measurements we quantify momentum transports associated with zonally symmetric stresses and turbulent stresses. Though a strong up-gradient flux of momentum by eddies is observed, measurements do not preclude the possibility that symmetric stresses play a critical role in maintaining the mean zonal circulation. Strong correlation between the observed meridional distribution of eddy-scale kinetic energy and available potential energy suggests coupling between the observed cloudtop turbulent motions and the upper tropospheric thermodynamics. We formulate an Oort energy budget for Jupiter's upper troposphere. Fourier analyses of turbulent motions within zonal jets suggest that large-scale Jovian turbulence obeys a k -5/3 power law, where k is the zonal wavenumber. This implies that the observed turbulence is two-dimensional with an up-gradient flow of kinetic energy fro g smaller scales (e.g., baroclinic scales). Turbulent kinetic energy generally peaks at the scale for which Rossby wave propagation begins as suggested by Rhines (1975).
Endophthalmitis Caused by Pseudomonas aeruginosa: Clinical Characteristics, Outcomes, and Antibiotics Sensitivities

Purpose The aim of this study is to report the clinical characteristics, visual outcomes, and antibiotic susceptibilities of patients with Pseudomonas aeruginosa endophthalmitis. Methods The medical records of patients with culture-proven Pseudomonas aeruginosa endophthalmitis treated from June 2013 to December 2019 were reviewed. Results This study included 36 eyes of 36 patients. The clinical settings included ocular trauma (15/36), corneal ulcer (9/36), postoperative endophthalmitis (5/36), endogenous (3/36), and unknown (4/36). Sixteen patients underwent evisceration, 13 patients underwent pars plana vitrectomy (PPV), 2 patients were treated with only intravitreal antibiotics, and 5 patients did not undergo surgery. Only one patient achieved a visual acuity of 20/400, and the others had all counting fingers or below. The cultured Pseudomonas aeruginosa was 100% sensitive to gentamicin, tobramycin, amikacin, ciprofloxacin, and levofloxacin and, approximately 95% sensitive to meropenem, imipenem, and aztreonam. Conclusion The visual outcomes of Pseudomonas aeruginosa endophthalmitis were very poor, and the evisceration rate remained high. Pseudomonas aeruginosa has good susceptibility to gentamicin, tobramycin, amikacin, ciprofloxacin, and levofloxacin.
An Analysis of the Postposing Construction in Japanese

This dissertation analyzes the postposing construction in Japanese — sentences in which one or more constituents appear following the matrix predicate. Two types of postposing are observed in my data, which are primarily distinguished by the presence or absence of a pause and a break in the intonation contour. It is argued that an "afterthought" analysis, which has been offered in the past, is inadequate and that at least the no-pause type of postposing should be regarded as movement. An analysis of the postposing construction is important, as well as interesting, for several reasons. First, postposed sentences appear to contradict the general claim that Japanese is a 'rigid' verb-final language. Second, the analysis presented here reaffirms recent findings that rules of Move-alpha do apply in this language. Third, an interaction of phonological, syntactic, semantic and pragmatic factors constrains the shape and use of postposed sentences, which suggests that all these factors must be taken into consideration in our analysis. And finally, despite its common usage in colloquial speech, there have been few attempts in the literature to account for this construction. My syntactic account of postposing adopts the framework of the Theory of Government and Binding (GB). Specifically, I analyze it as a root transformation that adjoins a maximal projection of all categories to the highest S \ I argue that a movement analysis is superior to a base-generation or construal analysis and that the former is compatible with the basic principles of GB, such as X-bar, Government, Binding, Theta, Case and Bounding Theories. Semantically, it is shown that both the degree of transparency of the verb and parsing factors have effects o the acceptability of postposed sentences. Pragmatically, while some sentences of the pause type express an "afterthought" (as we understand the term in its prototypical sense), the motivation of others are not so clear.
Energetic, ∼5–90 keV neutral atom imaging of a weak substorm with STEREO/STE

We present imaging and high resolution energy spectra of energetic ∼5–90 keV neutral atoms (ENA) of a weak geomagnetic substorm (Dst > −8 nT and AE ≲ 200 nT), made by the Suprathermal Electron (STE) instrument on the STEREO B spacecraft. Enhanced ENA emissions were observed coming from around local midnight near the equator with different spatial distribution and/or temporal behavior at ∼5–20keV compared to ∼20–90 keV. By forward modeling using a parameterized ring‐current model, we show that the ENA images imply the parent equatorial protons have pitch‐angle distributions peaked at 90°, an energy spectrum consistent with in situ proton measurements at geosynchronous orbit, and a spatial asymmetry with the maximum flux at midnight for 5–20 keV and at 2240 MLT for 20–90 keV. These are the first ENA measurements at ∼5 to 26 keV from low altitude, and the first for such weak activity.
POSTPARTUM OVARIAN ACTIVITY IN FRIESIAN COWS UNDER EGYPTIAN CONDITIONS

This investigation aimed at studing the cyclic and acyclic patterns of ovarian function in Friesian cattle. Twenty-one pregnant Friesian cows were taken randomly from a herd located at sakha experimental station, Animal Production Research Institute, Ministry of agriculture, Egypt. Cows were experimented 15-20 days before the expected calving day till two months after fertile insemination. Blood samples were withdrawn twice weekly at 3 - 4 days intervals. Plasma was used for assaying progesterone levels imploying radioimmunoassay. Heat detection was performed twice daily in all cows preconception. Results revealed that the overall mean of postpartum anestrus period was 80.4 days. During this period plasma progesterone was recorded at basal level (<0.5 ng/ml), postpartum anestrus period was prolonged in the highly milk producing cows compared to low producers (91.88 versus 61.23 days). The difference between low and high lactating cows in this respect was statistically insignificant. Overall average length of postpartum to first ovulation interval was 116.3 days. Postpartum to the first ovulatory estrus interval averaged 127.0 days, while days open averaged 186.1 days. Milk production had a significant (p<0.01) effect on postpartum to first ovulation and to first estrus intervals. Number of ovulations and inseminations /conception was 3.9 and 2.35, respectively with insignificant effect of milk production on both traits. The percentage of quiet ovulation was 41.7%. This percentage was 71.4% , 42.1% and 27.3% in the first, second and third postpartum ovulation, respectively. Forty one percent of the short low peak progesterone cycles was 9.79 days in length with an average progesterone peak of 2.2 ng/ml. Overall average length of regular normal progesterone cycles was 22.36 days with average progesterone peak of 6.37 ng/ml.