Miracle-dz/UniFAR-FTUs huggingface dataset:
Development of a dynamic mathematical model for investigating mammary gland metabolism in lactating cows

SUMMARY A dynamic mathematical model of a closed mammary system in lactating cows was developed to incorporate the setpoint concept of tissue activity, using equations where nutrient supply and absorption are locally regulated so as to maintain a given rate of milk protein yield. The model consists of 12 differential equations, 11 of which are concerned with intracellular biochemical compartments and one describes the volume of tissue actively perfused by blood (AP). The intracellular compartments are: amino acids (AAs), acetate, fatty acids (FAs), β-hydroxybutyrate, glucose-6-phosphate, fructose-6-phosphate, phospho-glyceraldehyde, pyruvate, mitochondrial acetyl-CoA, adenosine triphosphate (ATP) and adenosine diphosphate (ADP). The model simulates mechanisms which are aimed at reproducing and, thereby, explain variations in mammary plasma flow (MPF) observed experimentally. The AP changes according to variations in the metabolic status or in the metabolic requirements of the gland. Should the tissue energy charge (i.e. ATP/ADP ratio) exceed a baseline ratio, then AP decreases and consequently MPF declines. Conversely, when milk protein yield increases, AP increases and MPF rises. In the present model, AA uptake by the mammary gland is inhibited by intracellular AAs. It is also assumed that, when milk protein yield diminishes, the respiratory chain and ATP synthesis become uncoupled and consequently ATP yield is reduced. Model evaluation included behavioural analysis and sensitivity analysis. Behaviour analysis was conducted to test whether the model mechanisms reproduced the scenarios from which the model hypotheses were developed, and took into consideration: an increase in arterial glucose concentration (HIGLC), increases in arterial concentrations of non-esterified FAs, triacylglycerol and β-hydroxybutyrate (HIFAT), a 50% reduction of arterial histidine concentration (LOHIS), and a hyperinsulinaemic euglycaemic clamp (HIINS). Both HIGLC and HIFAT resulted in a decrease in MPF and in milk protein yield; moreover, the scenario HIGLC also produced a notable decrease in the extraction of glucose. The scenario LOHIS resulted in increased MPF and extraction of His from plasma. However these responses were not sufficiently large to prevent a severe reduction of milk protein yield which was accompanied by a reduction in the extraction of other essential AAs. The scenario HIINS resulted in an increase of MPF and of milk protein yield, in the extraction of His and of other essential AAs. Model sensitivity analysis focused on variation of both affinity and inhibition constants of some of the Michaelis–Menten equations. Improvements in model structure and directions for future research suggested by the modelling analysis are discussed.
What are the relationship between problematic internet use and subjective well-being and self-esteem? Investigation of an adolescent sample

The aim of this research is to determine whether subjective well-being and self-esteem predict problematic internet use or not. Within the scope of the study, the differentiation of problematic internet use according to some demographic variables was assessed. The study group for the research comprised 385 high school students (203 females, 182 males) attending 6 high schools in Trabzon province. Data were collected using the Problematic Internet Use Scale-E, Subjective Well-Being Scale, Coopersmith Self-Esteem Inventory and a Demographic Information Form. The results showed there was a negative significant correlation between problematic internet use with subjective well-being and self-esteem. Additionally, it was concluded that subjective well-being and self-esteem significantly predicted problematic internet use. Problematic internet use differed according to gender, family income level, duration spent on the internet, purpose of internet use and maternal education level, while it did not differ according to class level or paternal education level.
Prevalence and Pathogenicity of a Heterophyid Trematode Infecting the Gills of an Endangered Fish, the Fountain Darter, in Two Central Texas Spring-Fed Rivers

Abstract Gills of 194 fountain darters Etheostoma fonticola collected from the Comal River in Texas from May 1997 through May 1998 were found to be parasitized with 8–1,524 metacercarial cysts of a heterophyid trematode tentatively identified as Centrocestus formosanus. The intensity of infection varied among three sites on the Comal River. In contrast, of 130 darters from the nearby San Marcos River that were examined, only 4 (3%) were infected, and these had 1–2 cysts per fish. Of 2,279 Melanoides tuberculata snails from the Comal River that were examined, 139 (6.1%) were infected with the trematode. Only 1 snail in 2,241 from the San Marcos River that were examined was infected. The presence of metacercariae in darters was associated with flared opercula, shortened or thickened gill filaments, epithelial hyperplasia, and engorged lamellae. The normal cartilage support of the filaments was distorted and displaced, leading to severe deformities of filament structure. Gill damage was severe and possibly l.
Epidermal Growth Factor Negatively Regulates Chondrogenesis of Mesenchymal Cells by Modulating the Protein Kinase C-α, Erk-1, and p38 MAPK Signaling Pathways*

During limb development, epithelial cells in the apical ectodermal ridge keep the underlying mesenchymal cells in a proliferative state preventing differentiation by secreting signaling molecules such as epidermal growth factor (EGF). We investigated the molecular mechanism of the EGF effect on the regulation of micromass culture-induced chondrogenesis of chick limb bud mesenchymal cells as a model system. We found that expression and tyrosine phosphorylation of the EGF receptor was increased transiently during chondrogenesis. Exogenous EGF inhibited chondrogenic differentiation of mesenchymal cells, and this effect was reversed by the EGF receptor inhibitor AG1478. EGF treatment also inhibited the expression and activation of protein kinase C-α, whereas it activated Erk-1 and inhibited p38 mitogen-activated protein kinase, all of which appeared to be involved in the EGF-induced inhibition of chondrogenesis. Stimulation of the EGF receptor blocked precartilage condensation and altered the expression of cell adhesion molecules such as N-cadherin and integrins α5 and β1. All these EGF effects were reversible by AG1478. The data indicate that EGF negatively regulate chondrogenesis of chick limb bud mesenchymal cells by inhibiting precartilage condensation and by modulating signaling pathways including those of protein kinase C-α, Erk-1, and p38 mitogen-activated protein kinase.
Distribution of the spotted seal Phoca largha along the coast of Hokkaido, Japan

The distribution of the spotted seal, Phoca largha, along the coast of Hokkaido was investigated, based on personal interviews, surveys of haul-out sites, and records and direct examinations of seals. Interviews conducted in 1997 along the entire coastline of Hokkaido, confirmed that spotted seals have been observed in all eight regions of the island. Incidental harvests by fishing nets and damage control kills were confirmed in seven and in three regions, respectively. Examinations were made of live and dead specimens, and of specimen records from between 1971 and 1998 (n=605), all obtained from Hokkaido University, aquariums and zoos. Specimen and documentary records were most common in regions where incidental harvests and damage control kills were reported. Seasonal and regional variations in seal distributions were observed. Incidental harvests, damage control kills, and strandings were most common during salmon harvest season (fall), sea ice season, and the weaning period, respectively. Sub-adults and adults were found in areas with seasonal sea ice, while immature seals were recovered from areas with little or no sea ice. The fewest seal sightings and no haul-out sites were reported from southern Hokkaido, probably because warm sea currents discourage seals from using this area.
List Decoding of Arıkan’s PAC Codes †

Polar coding gives rise to the first explicit family of codes that provably achieve capacity with efficient encoding and decoding for a wide range of channels. However, its performance at short block lengths under standard successive cancellation decoding is far from optimal. A well-known way to improve the performance of polar codes at short block lengths is CRC precoding followed by successive-cancellation list decoding. This approach, along with various refinements thereof, has remained the state of the art in polar coding since it was first introduced in 2011. Last year, Arıkan presented a new polar coding scheme, which he called polarization-adjusted convolutional (PAC) codes. Such PAC codes provide another dramatic improvement in performance as compared to CRC-aided list decoding. These codes are based primarily upon the following main ideas: replacing CRC precoding with convolutional precoding (under appropriate rate profiling) and replacing list decoding by sequential decoding. Arıkan’s simulation results show that PAC codes, resulting from the combination of these ideas, are quite close to finite-length lower bounds on the performance of any code under ML decoding.One of our main goals in this paper is to answer the following question: is sequential decoding essential for the superior performance of PAC codes? We show that similar performance can be achieved using list decoding when the list size L is moderately large (say, L ⩾ 128). List decoding has distinct advantages over sequential decoding in certain scenarios such as low-SNR regimes or situations where the worst-case complexity/latency is the primary constraint. Another objective is to provide some insights into the remarkable performance of PAC codes. We first observe that both sequential decoding and list decoding of PAC codes closely match ML decoding thereof. We then estimate the number of low weight codewords in PAC codes, and use these estimates to approximate the union bound on their performance under ML decoding. These results indicate that PAC codes are superior to polar codes and Reed-Muller codes, and suggest that the goal of rate-profiling may be to optimize the weight distribution at low weights.
Effect of Winter Crop Species on Arbuscular Mycorrhizal Fungal Colonization and Subsequent Soybean Yields

Abstract We evaluated how the cultivation of arbuscular mycorrhizal fungi (AMF) host (wheat) and non-host (rapeseed) crops affects the subsequent soybean crop by assessing AMF spore density and AMF colonization, phosphorus (P) uptake by soybean and yields of soybean over a 4-year period. Every year wheat or rapeseed was cultivated from autumn to spring and soybean from spring to autumn. From the first to fourth year, AMF spore density was higher in the plot after the cultivation of wheat (wheat plot) than in the rapeseed plot. From the second to fourth year, the AMF colonization ratio was higher in the wheat plot than in the rapeseed plot. In the first year, there was no difference in the AMF colonization ratio, growth, and P uptake by soybean plants between the rapeseed plot and wheat plot. However, from the second to fourth year, AMF colonization ratio, plant growth, and P uptake by soybean in the wheat plot were higher than those in the rapeseed plot. The soybean yields in both plots gradually decreased from the first to fourth year, but, in the second and the fourth year, soybean yields were higher in the wheat plot than in the rapeseed plot. Soybean yield was significantly correlated with the AMF colonization ratio, but not with AMF spore density. Therefore, we concluded that AMF colonization is not determined by AMF spore density alone, and other factors influence the AMF colonization in subsequent soybean plants. It is important to increase the AMF colonization ratio to increase soybean yield.
Changes in nematode antigens recognized by monoclonal antibodies during early infections of soya beans with the cyst nematode Heterodera glycines

SUMMARY The invasion and establishment of Heterodera glycines has been studied for 0–120 h after addition to host roots using a synchronized infection system. A high degree of synchrony in development was noted, with juvenile nematodes reaching their feeding sites adjacent to the root endodermis and discharging their subventral pharyngeal glands by 24 h post-invasion (p.i.). The moult to the 3rd-stage juvenile occurred approximately 89 h after entry to the root. Using an enzyme-linked immunosorbent assay with monoclonal antibodies (MAbs) whose tissue specificities had already been defined by immuno-cytochemistry, it was found that MAbs recognizing intestinal lipid droplets and granules showed a major increase in reactivity 18–24 h p.i. before declining by 39 h p.i. In contrast, the reactivity of two MAbs recognizing adult cuticle increased significantly only after 89 h p.i. , following the second moult. MAbs to the two subventral pharyngeal gland cells showed a variety of patterns of changing reactivity during the experiment. One increased within 24 h of invasion before declining whereas a second fell without any initial rise. Two further MAbs specific for the subventral glands initially declined but showed a secondary increase in reactivity after 72 h and could be detected in adult females. This pattern was also seen in a MAb specific for the dorsal pharyngeal gland cell. These changes are discussed in the context of events taking place following invasion, with particular reference to the initiation and maintenance of a feeding syncytium by the developing nematode.
Studies of dense nuclear matter at NICA

Laboratory experiments with high-energetic heavy-ion collisions offer the opportunity to explore fundamental properties of nuclear matter, such as the high-density equation-of-state, which governs the structure and dynamics of cosmic objects and phenomena like neutron stars, supernova explosions, and neutron star mergers. A particular goal and challenge of the experiments is to unravel the microscopic degrees-of-freedom of strongly interaction matter at high density, including the search for phase transitions, which may feature a region of phase coexistence and a critical endpoint. As the theory of strong interaction is not able to make firm predictions for the structure and the properties of matter high baryon chemical potentials, the scientific progress in this field is driven by experimental results. The mission of future experiments at FAIR and NICA, which will complement the running experimental programs at GSI, CERN, and RHIC, is to explore new diagnostic probes, which never have been measured before at collision energies, where the highest net-baryon densities will be created. The most promising observables, which are expected to shed light on the nature of high-density QCD matter, comprise the collective flow of identified particles including multi-strange (anti-) hyperons, fluctuations and correlations, lepton pairs, and charmed particles. In the following, the perspectives for experiments in the NICA energy range will be discussed.
A Re-visit of the Popularity Baseline in Recommender Systems

Popularity is often included in experimental evaluation to provide areference performance for a recommendation task. To understand how popularity baseline is defined and evaluated, we sample 12 papers from top-tier conferences including KDD, WWW, SIGIR, and RecSys, and 6 open source toolkits. We note that the widely adoptedMostPop baseline simply ranks items based on the number of interactions in the training data. We argue that the current evaluation of popularity (i) does not reflect the popular items at the time when a user interacts with the system, and (ii) may recommend items released after a user's last interaction with the system. On the widely used MovieLens dataset, we show that the performance of popularity could be significantly improved by 70% or more, if we consider the popular itemsat the time point when a user interacts with the system. We further show that, on MovieLens dataset, the users having lower tendencies on movies tend to follow the crowd and rate more popular movies. Movie lovers who rate a large number of movies, rate movies based on their own preferences and interests. Through this study, we call for a re-visit of the popularity baseline in recommender system to better reflect its effectiveness.
Quantum gravity on polygons and $\Bbb R\times \Bbb Z_n$ FLRW model

We fully solve the quantum geometry of $\Bbb Z_n$ as a polygon graph with arbitrary metric lengths on the edges, finding a $*$-preserving quantum Levi-Civita connection which is unique for $n\ne 4$. As a first application, we numerically compute correlation functions for Euclideanised quantum gravity on $\Bbb Z_n$ for small $n$. We then study an FLRW model on $\Bbb R\times\Bbb Z_n$, finding the same expansion rate as for the classical flat FLRW model in 1+2 dimensions. We also look at particle creation on $\Bbb R\times \Bbb Z_n$ and find an additional $m=0$ adiabatic no particle creation expansion as well as the particle creation spectrum for a smoothed step expansion.
A Corpus for Large-Scale Phonetic Typology

A major hurdle in data-driven research on typology is having sufficient data in many languages to draw meaningful conclusions. We present VoxClamantis v1.0, the first large-scale corpus for phonetic typology, with aligned segments and estimated phoneme-level labels in 690 readings spanning 635 languages, along with acoustic-phonetic measures of vowels and sibilants. Access to such data can greatly facilitate investigation of phonetic typology at a large scale and across many languages. However, it is non-trivial and computationally intensive to obtain such alignments for hundreds of languages, many of which have few to no resources presently available. We describe the methodology to create our corpus, discuss caveats with current methods and their impact on the utility of this data, and illustrate possible research directions through a series of case studies on the 48 highest-quality readings. Our corpus and scripts are publicly available for non-commercial use at https://voxclamantisproject.github. io.
Evaluation de la perte d'oeufs lors de l'incubation chez nephrops norvegicus (L.) dans la région Sud-Bretagne, France

Loss of eggs during the incubation period in ovigerous females of Nephrops norvegicus from the Bay of Biscay is calculated using two different methods. The first calculates the egg loss from incubation stage A to stage D. The second calculates the loss between the end of ovary maturation and incubation stage D. The first method may contain a bias which decreases the loss estimation: loss of eggs during trawling may be higher in stage A than in stage D. In the Bay of Biscay, the loss of eggs in ovigerous females of Nephrops norvegicus would be about 45-50% for the entire incubation period. Our result is quite different from the 75% obtained by other workers in Portuguese waters. Loss of eggs during incubation which may be due mainly to predation may be a means of density regulation (stock-recruitment relationship). The differences observed in loss of eggs between the South-Brittany area and Portuguese waters may result from differences in fishing mortalities or in the density of predators.
Deceptive Deletions for Protecting Withdrawn Posts on Social Platforms

Over-sharing poorly-worded thoughts and personal information is prevalent on online social platforms. In many of these cases, users regret posting such content. To retrospectively rectify these errors in users' sharing decisions, most platforms offer (deletion) mechanisms to withdraw the content, and social media users often utilize them. Ironically and perhaps unfortunately, these deletions make users more susceptible to privacy violations by malicious actors who specifically hunt post deletions at large scale. The reason for such hunting is simple: deleting a post acts as a powerful signal that the post might be damaging to its owner. Today, multiple archival services are already scanning social media for these deleted posts. Moreover, as we demonstrate in this work, powerful machine learning models can detect damaging deletions at scale. Towards restraining such a global adversary against users' right to be forgotten, we introduce Deceptive Deletion, a decoy mechanism that minimizes the adversarial advantage. Our mechanism injects decoy deletions, hence creating a two-player minmax game between an adversary that seeks to classify damaging content among the deleted posts and a challenger that employs decoy deletions to masquerade real damaging deletions. We formalize the Deceptive Game between the two players, determine conditions under which either the adversary or the challenger provably wins the game, and discuss the scenarios in-between these two extremes. We apply the Deceptive Deletion mechanism to a real-world task on Twitter: hiding damaging tweet deletions. We show that a powerful global adversary can be beaten by a powerful challenger, raising the bar significantly and giving a glimmer of hope in the ability to be really forgotten on social platforms.
Mixing and combustion in a laminar shear layer with imposed counterflow

Abstract Three-dimensional, steady laminar flow structures with mixing, chemical reaction, normal strain and shear strain representative of turbulent combustion are analysed. A mixing layer is subjected to counterflow in the transverse $y$- and $z$-directions providing the important practical interaction of shear-strain rate with normal-strain rate. Larger consequences for mixing rates and burning rates occur than would appear with shear strain or normal strain alone. The three characteristic times for chemical reaction, normal strain and shear strain are cast through two ratios: a Damköhler number based on rate of shear strain and a ratio of rate of normal strain to rate of shear strain. Reduction to a one-dimensional similar form is obtained with density and property variations. A generalization is found extending the Crocco integral for non-unitary Prandtl number and for imposed normal strain. A diffusion flamelet model with combined shear and normal strains is developed. Another similar solution is obtained for a configuration with a dominant diffusion flame and a weaker fuel-rich premixed flame. A conserved scalar is cast as the independent variable giving an alternative description. The imposed normal strain decreases mixing-layer thickness and increases scalar gradients and transport rates. Diffusion control is possible for partially premixed flames in the multi-branched flame situation. The imposition of shear strain and thereby vorticity on the counterflow can have a substantial consequence, indicating the need for flamelet models with both shear strain and normal strain.