Miracle-dz/UniFAR-FTUs huggingface dataset:
A Node Ranking Method Based on Multiple Layers for Dynamic Protein Interaction Networks

Constructing dynamic protein interaction networks (DPIN) is a common way to improve identification accuracy of essential proteins. The existing methods usually aggregate DPIN into a single-layer network where all nodes are sorted by their importance. This treatment makes the dynamic information about proteins in multiple layers lost in the single layer, and thus affects the identification accuracy of essential proteins. This paper proposes a node ranking method based on multiple layers for DPIN to address the problem. First, we calculate the centrality values of all nodes for each time-specific layer, then work out the centrality score of each node by dividing the total of its centrality values across all layers by its layer activity, and finally sort the importance of all nodes by their centrality scores. Different from the methods based on single layer, our method makes full use of centrality values of each protein in time-specific layers, and thus can more effectively utilize the dynamic information of proteins. To evaluate the effectiveness of the node ranking method based on multiple layers, we apply ten network-based centrality methods on multiple layers and compare the results with those on a single layer. Then the predictive performance of the ten centrality methods are validated in terms of sensitivity, specificity, positive predictive value, negative predictive value, F-measure and accuracy. The experimental results for the identification of essential proteins show that the node ranking method based on multiple layers is superior to those based on a single layer and can help to identify essential proteins more accurate.
Identification of Three Epichloë Endophytes from Hordeum bogdanii Wilensky in China

Cool season grasses often form reciprocal symbiotic relationships with endophytic fungal species in genus Epichloë. In this study, we characterized three fungal endophytes isolated from the grass Hordeum bogdanii native to northwest China. Based on morphological characteristics and phylogenetic analyses of tefA, tubB, and actG sequences, we identified them as Epichloë sp. HboTG-2 (H. bogdanii Taxonomic Group 2: E. bromicola × E. typhina). Alkaloid synthesis related genes analysis showed that Epichloë sp. HboTG-2 may have the ability only to produce peramine which is toxic to insects but not to animals. In the process of this study, we did not observe sexual structures or epiphyllous growth on leaves of infected plants.
WEAKLY STABLE IDEALS OF EXCHANGE RINGS

Let I be an ideal of an exchange ring R. We say that I is weakly stable provided that every regular element in 1+I is one-sided unit-regular. If I is weakly stable, then so is Mn(I) as an ideal of Mn(R). Also every square regular matrix over such an ideal admits a diagonal reduction by right or left invertible matrices. These extend the corresponding results of [1],[6-8],[10] and [12-13].
Multiadaptive Spatiotemporal Flow Graph Neural Network for Traffic Speed Forecasting

Traffic speed forecasting plays an important role in intelligent traffic monitoring systems. Existing methods mostly predefine a fixed adjacency matrix to capture the spatial correlation between sensors in a traffic network. However, there are multiple hidden spatial correlations between sensors. A single fixed adjacency matrix cannot adaptively capture multiple spatial correlations. To overcome this limitation, we proposed a novel multiadaptive spatiotemporal flow graph neural network (MAF-GNN) for traffic speed forecasting. Specifically, MAF-GNN mainly consists of a multiadaptive adjacency matrix mechanism and a spatiotemporal flow mechanism. The multiadaptive adjacency matrix mechanism was proposed to adaptively capture multiple hidden spatial correlations between sensors. The spatiotemporal flow mechanism was proposed to further enhance the capture of temporal and spatial correlations. The experimental results on two real-world traffic datasets, METR-LA and PeMS-Bay, demonstrated the superiority of MAF-GNN. MAF-GNN outperformed baseline models in 1-h ahead forecasting.
Brick by Brick: Landmark Studies on Reading Development, Assessment, and Instruction for Students Who Are English Learners

E learners (ELs) are the fastest growing population of students in the United States. There are over 4.8 million ELs enrolled in K-12 schools (U.S. Department of Education, 2017). The U.S. Census Bureau estimates that by 2030, EL students will compose 40% of the schoolage population (U.S. Department of Education, 2003). As the student population continues to become more culturally and linguistically diverse, educators are faced with the challenging task of ensuring that all students receive effective instruction and acquire English literacy. How can teachers help students with little or no exposure to English become proficient readers in a language different from the one spoken in their homes? What do we know about the reading development of EL students compared to that of English monolingual (EM) students? Most of the research investigating reading development has been conducted with EM students. However, over the past few decades, there have been a series of landmark studies showing how reading development for ELs is not all that different from reading development for EM students. This article will highlight some of these studies, which have provided us with three key findings: 1. The simple view of reading also applies to ELs. 2. The same early indicators of reading risk status predict later reading performance for ELs and EM students. 3. Early intervention research shows that ELs can achieve the same level in word reading as their EM peers when they receive evidence-based instruction that is aligned with the science of reading.
Cultural governance within and across cities and regions: Evidence from the English publicly funded arts sector

There are significant inequalities in the publicly funded arts sector in England, including significant spatial inequalities. If anything, the critique of spatial inequalities in this ecology do not go far enough. This article uses a unique dataset of the boards of directors of Arts Council England’s national portfolio, derived from Companies House. While a majority of national portfolio organisations do not share board members with any other organisation, the analysis demonstrates that London-based organisations are significantly more likely to share board members with other companies than organisations outside London – and that, where an organisation outside of London does share a board member with a company in another region, it is more likely to be with a company in London than all other regions put together. It further demonstrates that this effect is most pronounced where these organisations are part of the same artform. Crucially, the organisations connected to London have more than double the portfolio income of other organisations, whether they share board members or not. This illustration of the concentration of power in London in the publicly funded arts sector, over and above the distribution of organisations in general, demonstrates the conceptual value of a cultural economy that emerges from interconnections within a local or national ecosystem. At the same time, the analysis and findings push the cultural ecology literature to centre inequality as a core issue as the concept is developed. Even the local cultural ecosystem is not exempt from the impact of the nation’s uneven (cultural) geography.
Hydroxyapatite Reinforced Polyvinyl Alcohol/Polyvinyl Pyrrolidone Based Hydrogel for Cartilage Replacement

Polyvinyl alcohol (PVA) and Polyvinyl Pyrrolidone (PVP) hydrogels are desirable biomaterials for soft tissue repair and replacement. However, the bio-inertness and poor cell adhesive potency of the PVA and PVP hinder the wide range of biomedical applications. In the present work, PVA and PVP were blended with a one-dimensional hydroxyapatite nanorod (HNr), and PVA/PVP/HNr composite hydrogel was synthesized by the freeze-thaw process. The developed hydrogels were characterized by Scanning Electron Microscope (SEM). The bio-ceramic nanohydroxyapatite content was optimized, and it was found that reinforcement improves mechanical strength as well as bioactivity. The compression strength values are 2.47 ± 0.73 MPa for the composite having 2 wt% of nanohydroxyapatite. The storage modulus was much higher than the loss modulus, which signifies the elastic dominancy similar to cartilage. Besides, the antimicrobial activity of nanohydroxyapatite reinforced PVA hydrogel towards bacterial species, Escherichia coli (E. Coli), Staphylococcus aureus (S. aureus) was satisfactory, and the in vitro biocompatibility response towards Human Mesenchymal stem cells(hMSC) after 72 h of culture confirms nanohydroxyapatite reinforced PVA/PVP hydrogels are the promising alternatives for next-generation cartilage substitutes.
Rebooting Regulatory T Cell and Dendritic Cell Function in Immune-Mediated Inflammatory Diseases: Biomarker and Therapy Discovery under a Multi-Omics Lens

Immune-mediated inflammatory diseases (IMIDs) are a group of autoimmune and chronic inflammatory disorders with constantly increasing prevalence in the modern world. The vast majority of IMIDs develop as a consequence of complex mechanisms dependent on genetic, epigenetic, molecular, cellular, and environmental elements, that lead to defects in immune regulatory guardians of tolerance, such as dendritic (DCs) and regulatory T (Tregs) cells. As a result of this dysfunction, immune tolerance collapses and pathogenesis emerges. Deeper understanding of such disease driving mechanisms remains a major challenge for the prevention of inflammatory disorders. The recent renaissance in high throughput technologies has enabled the increase in the amount of data collected through multiple omics layers, while additionally narrowing the resolution down to the single cell level. In light of the aforementioned, this review focuses on DCs and Tregs and discusses how multi-omics approaches can be harnessed to create robust cell-based IMID biomarkers in hope of leading to more efficient and patient-tailored therapeutic interventions.
Shared Decision-Making Facilitates Inhaler Choice in Patients with Newly-Diagnosed Chronic Obstructive Pulmonary Disease: A Multicenter Prospective Study

Purpose Inadequate inhaler technique and nonadherence to therapy are associated with poorer clinical outcomes in chronic obstructive pulmonary disease (COPD). Shared decision-making (SDM), based on clinical evidence, patient goals and preferences, improves quality of care. This study aims to investigate the initial patients’ choices of inhaler devices in patients with newly-diagnosed COPD after an SDM process. Patients and Methods We conducted a prospective, observational, multi-center study in four hospitals in Taiwan from December 2019 to July 2021. All treatment-naïve patients with newly-diagnosed COPD who were able to use three different inhalers of dual bronchodilators (Respimat®, Ellipta®, and Breezhaler®) in the outpatient setting were enrolled. After an SDM process, every patient was prescribed with one inhaler chosen by him- or herself. Errors of using inhalers were recorded after prescription of the inhaler, and at the follow-up visit a month later. The patients’ adherence, satisfaction score, and willingness to keep the initially chosen inhaler were investigated. Results In 109 enrolled patients, 43, 45, and 21 patients chose Respimat®, Ellipta®, and Breezhaler®, respectively. Patients chose different inhalers had similar rates of critical error on both visits, while the rates greatly decrease on the follow-up visit, no matter which inhaler devices they chose initially. The majority of patients had good adherence (use as the prescription daily, n = 79, 82%), satisfaction (satisfaction score ≥4, n = 70, 73%), and strong willingness to keep the initial inhaler (n = 89, 93%) on the follow-up visit regardless of disease severity and their comorbidities. Conclusion SDM might facilitate inhaler choosing, reduce inhaler errors (versus baseline) with good adherence, satisfaction and strong willingness to keep the initial inhaler in patients with newly-diagnosed COPD.
Role of social aggregation in the fitness cost of pyrethroid‐resistant German cockroaches

Living in aggregations likely gives fitness benefits to resistant German cockroaches. We first investigated the trade‐offs in life‐history traits between six field pyrethroid‐resistant German cockroach strains and a laboratory susceptible strain (SUS‐1). Second, each strain was placed in groups of 2, 10, 20, 30 and 40 individuals with an equal sex ratio in each group to investigate the effect of social aggregation on fitness and overall population parameters. All resistant strains exhibited reduced nymphal survival (50%–83%) and a prolonged development period in both male (49–63 days) and female (47–62 days) nymphs when compared to SUS‐1 individuals (nymphal development period: 39 ± 2 days for male and 40 ± 3 days for female). Such fitness costs were minimized when the resistant cockroaches were in aggregations. Specifically, male (54 ± 3 days) and female nymphal development periods (52 ± 3 days) of German cockroach significantly decreased to 44 ± 1 days in the largest group. The nymphal survival was substantially enhanced (more than 80% survival) in German cockroaches with elevated cytochrome P450 monooxygenases, or both cytochrome P450 monooxygenases and esterases activities in the largest group. The effect of pyrethroid resistance on the life‐history traits of adult German cockroaches was limited; only adult male longevity was significantly prolonged. Group living did not significantly extend adult longevity and increase the number of offspring per ootheca. Contrary to expectations, the number of nymphs produced by a female and the oothecal hatchability were inversely proportional to the number of individuals in aggregations. Moreover, a lower proportion of viable oothecae were produced in German cockroaches when living in aggregations. Because of low fecundity, population parameters of German cockroaches living in aggregations (net reproductive rate and intrinsic rate of increase) were significantly lower than the parameters of those living in pairs.
Comparing Essentiality of SOS1-Mediated Na+ Exclusion in Salinity Tolerance between Cultivated and Wild Rice Species

Soil salinity is a major constraint that affects plant growth and development. Rice is a staple food for more than half of the human population but is extremely sensitive to salinity. Among the several known mechanisms, the ability of the plant to exclude cytosolic Na+ is strongly correlated with salinity stress tolerance in different plant species. This exclusion is mediated by the plasma membrane (PM) Na+/H+ antiporter encoded by Salt Overly Sensitive (SOS1) gene and driven by a PM H+-ATPase generated proton gradient. However, it is not clear to what extent this mechanism is operational in wild and cultivated rice species, given the unique rice root anatomy and the existence of the bypass flow for Na+. As wild rice species provide a rich source of genetic diversity for possible introgression of abiotic stress tolerance, we investigated physiological and molecular basis of salinity stress tolerance in Oryza species by using two contrasting pairs of cultivated (Oryza sativa) and wild rice species (Oryza alta and Oryza punctata). Accordingly, dose- and age-dependent Na+ and H+ fluxes were measured using a non-invasive ion selective vibrating microelectrode (the MIFE technique) to measure potential activity of SOS1-encoded Na+/H+ antiporter genes. Consistent with GUS staining data reported in the literature, rice accessions had (~4–6-fold) greater net Na+ efflux in the root elongation zone (EZ) compared to the mature root zone (MZ). Pharmacological experiments showed that Na+ efflux in root EZ is suppressed by more than 90% by amiloride, indicating the possible involvement of Na+/H+ exchanger activity in root EZ. Within each group (cultivated vs. wild) the magnitude of amiloride-sensitive Na+ efflux was higher in tolerant genotypes; however, the activity of Na+/H+ exchanger was 2–3-fold higher in the cultivated rice compared with their wild counterparts. Gene expression levels of SOS1, SOS2 and SOS3 were upregulated under 24 h salinity treatment in all the tested genotypes, with the highest level of SOS1 transcript detected in salt-tolerant wild rice genotype O. alta (~5–6-fold increased transcript level) followed by another wild rice, O. punctata. There was no significant difference in SOS1 expression observed for cultivated rice (IR1-tolerant and IR29-sensitive) under both 0 and 24 h salinity exposure. Our findings suggest that salt-tolerant cultivated rice relies on the cytosolic Na+ exclusion mechanism to deal with salt stress to a greater extent than wild rice, but its operation seems to be regulated at a post-translational rather than transcriptional level.
PARASITOSIS IN CLARIAS GARIEPINUS AND ITS RELATION TO SOME ENVIRONMENTAL CONDITIONS IN ASSIUT GOVERNORATE, EGYPT

Fish like any other organisms, are susceptible to ecto & endo-parasites, which have a risky impact in aquaculture specially those because skin infection with secondary bacterial infection. This study estimated the parasitic infections in freshwater Catfish ( Clarias gariepinus ) in Assiut Governorate, and evaluated environmental factors affecting them. A total of 100 samples of different sexes and sizes were randomly collected weekly over one year from different localities in Assiut City. The fish were examined parasitological for ecto-parasites and dissected for endo-parasites as well as histopathological examination of muscles. The results showed an overall parasitic rate of 82%. Ecto-parasites were Gyrodactylus , Dactylogrus , Henneguya and Icthyophthirius multifiliis (2%, 8%, 2% & 5%) respectively, while endoparasites were trematode (Orientocreadium batrachoides 26% ), cestode ( Polyochobothrium clarias and Monobothrioides 6% & 21% respectively), nematode ( Paracamallanus spp. 12%), encysted metacercaria (66%) and protozoa ( Entamoeba spp. 15%). The variation between the parasitic number length, weight, and sex seasonally were statistically analyzed.
Consumers' Intention to Continue Using Cryptocurrency Mobile Wallets in Malaysia

In Malaysia, over RM 800 million transactions were processed in one cryptocurrency platform. The central bank of Malaysia has made e-payment one of its top targets to execute a cashless payment system. However, an in-depth analysis of the literature shows a dearth of research focusing on the influencers of cryptocurrency mobile wallet acceptance, especially the intention to use them continuously. Therefore, this study uses the Post-Acceptance Model of IS Continuance to determine the elements influencing the continuance intention of cryptocurrency mobile wallets in Malaysia. This research also investigates the impact of perceived security, effort expectations, and social influence on the intention to continue the usage of cryptocurrency mobile wallets. The empirical evidence from 106 current cryptocurrency respondents shows that: (1) perceived security and satisfaction are significant factors of continuance intention, and (2) performance expectancy, effort expectancy, and social influence are insignificant factors of continuance intention. It reveals perceived security as one of the critical elements in continuance intention in the cryptocurrency field.
Pedagogical competence

In this manual, the general methodical principles of developmental education for students of Pedagogy and Psychology, the meaning and essence of the concept of self-development, the specific features of the formation of self-development competence in students based on the cluster of pedagogical education, the content of educational materials of education based on the competence approach, modern traditional and distance education teaching methods and technologies, socio-cultural environment, methodological aspects of the self-development process of students in the conditions of an educational cluster, self-awareness and management, the model of individual self-development and modern approaches, the importance of independent education in the formation of competence, methods of determining the level of competence formation, this process includes the use of interactive methods and evaluation of the effectiveness of this process. This manual was prepared on the basis of the curriculum of masters of education in pedagogy and psychology, and is intended for use by pedagogues, scientific researchers and undergraduate students working at all levels of the continuing education system.
The Effect of Coaching Leadership Styles Towards Motivational Factors Among Selangor and UITM Lions Rugby Players

The objective of this research is to investigate the effect of coaching leadership styles towards motivational factors among Selangor and UITM Lions rugby players. The sample was chosen from two of the best rugby team in Selangor respectively. Purposive sampling was employed to pick the sample of 66 rugby players. As the primary instrument for acquiring information about coaching leadership styles and motivational factors, they were given an online questionnaire to complete. The Leadership Scale for Sport - 15 Version (LSS-15) questionnaire is used to determine coaching leadership styles, while the Sport Motivation Scale-II (SMS-II) is used to determine motivational factors. All data in this study was analysed using the Statistical Package for Social Science (SPSS) version 26.0. The mean of the data was generated using descriptive analysis to determine the preferred coaching leadership styles among rugby players and the motivational factors among rugby players. The relationship between coaching leadership styles and motivational factors among rugby players was analysed using Spearman Correlation. The researcher discovered that there is significant relationship between leadership styles towards motivational factors.
Prevalence and Associated Risk Factors of Human Intestinal Helminths Parasitic Infections in Ethiopia: A Systematic Review and Meta-Analysis

Background Intestinal helminth infections are still public health problems in tropical and subtropical countries including Ethiopia. This review and meta-analysis aimed to produce the pooled prevalence and associated risk factors of human intestinal helminth parasitic infections (HIHPIs) in Ethiopia. Methods Articles written in English were searched from online databases. Sixty-seven studies were included. Meta-analysis was computed using STATA version 14. Result The pooled prevalence of HIHPIs was (33.35%, 95% CI: 28.85%, 37.86%). Ascaris lumbricoides (10.84%, 95% CI: 9.34, 12.34), hookworm spp. (8.89%, 95% CI: 7.75, 10.04), Schistosoma mansoni (4.22%, 95% CI: 3.64, 4.81), Trichuris trichiura (2.51%, 95% CI: 2.17, 2.86), Hymenolepis nana (2.29%, 95% CI: 1.96, 2.63), Taenia species (1.01%, 95% CI: 0.80, 1.22), Strongyloides stercoralis (1.17%, 95% CI: 0.92, 1.41), and Enterobius vermicularis(0.71%, 95% CI: 0.52, 0.90) were recorded. Handwashing before food (OR: 5.22,95% CI: 3.49, 6.94), handwashing after toilet (OR: 3.03, 95%; CI: 1.01, 5.05), age (OR: 1.66, 95% CL. 1.09, 2.23), open defecation (OR: 2.42, 95% CI: 1.60, 3.24), eating raw and unwashed vegetables/fruits (OR: 1.98, 95%; CI: 1.30, 2.66), maternal education (OR: 1.81, 95% CI: 0.91, 2.72), family income (OR: 2.00, 95% CI: 0.87, 3.31), source of drinking water (OR: 3.12, 95% CI: 1.96, 4.27), swimming/contact with river water (OR: 1.90, 95% CI: 1.11, 2.69), barefoot (OR: 3.28, 95% CI: 1.67, 4.88), playing with soil (OR: 2.64, 95% CI: 1.40, 3.88), and family size (OR: 3.75, 95% CI: 2.03, 5.46) were factors associated with HIHPIs in Ethiopia. High heterogeneity of the prevalence of HIHPIs was observed among the studies within and among regions (I2 > 99.6% and P ≤ 0.001). Conclusion HIHPIs in Ethiopia were significantly high. Therefore, special attention should be given by all stakeholders to minimize HIHPIs in Ethiopia.