Miracle-dz/UniFAR-FTUs huggingface dataset:
A critical review of state‐of‐the‐art chatbot designs and applications

Chatbots are intelligent conversational agents that can interact with users through natural languages. As chatbots can perform a variety of tasks, many companies have committed numerous resources to develop and deploy chatbots to enhance various business processes. However, we lack an up‐to‐date critical review that thoroughly examines both state‐of‐the‐art technologies and innovative applications of chatbots. In this review, we not only critically analyze the various computational approaches used to develop state‐of‐the‐art chatbots, but also thoroughly review the usability and applications of chatbots for various business sectors. We also identify gaps in chatbot‐related studies and propose new research directions to address the shortcomings of existing studies and applications. Our review advances both academic research and practical business applications of state‐of‐the‐art chatbots. We provide guidance for practitioners to fully realize the business value of chatbots and assist in making sensible decisions related to the development and deployment of chatbots in various business contexts. Researchers interested in the design and development of chatbots can also gain useful insights from our critical review and identify fruitful research topics and future research directions based on the research gaps discussed herein.
Finite Element Simulation of the Instrumented Indentation Test to Estimate the Mechanical Properties for ASTM516-G70 and AISI1010 steels

Instrumented indentation technique at micro-scales has become more popular to determine mechanical properties of materials like hardness, modulus of elasticity, and yield strength. It is introduced as a method that finds the stress-strain curve, instead of the traditional tensile test. Furthermore, it gives a possibility to determine the mechanical properties for small specimens and material under operation in the field. Several researchers have attempted to evaluate this method experimentally and to investigate the factors affecting it by using a different shape of indenters, and different types of materials. In the same regard, this research work is conducted to evaluate this method experimentally and by finite element simulation methods. Two types of industrially significant steels were selected; they are namely ASTM516-G70, AISI1010 steel; and two shapes of indenters, blunt and sharp (Spherical, and Vickers) were used. The finite element simulation has been performed by ABAQUS simulation program, and its results were then compared with the experimental test results obtained from Nanovea instrumented indentation test machine. The results obtained have demonstrated good agreement between the experimental and the finite element simulation results within 5 % difference for young’s module, and 7.7 % for yield strength whereas excellent agreement is observed in the elastic region and the beginning of the plastic region for the engineering stress-strain curve. Finally, it is to be emphasized that the obtained results are more applicable for the tested materials, and further research is recommended to accommodate other materials as well and to confirm the generality of this method.
User-Based Quality of Service Aware Multi-Cell Radio Access Network Slicing

5G radio access network (RAN) slicing envisions a solution to flexibly deploy heterogeneous services as slices sharing the same infrastructure. However, this level of flexibility renders slice isolation challenging, mainly due to the stochastic nature of wireless resources. In the state-of-the-art, RAN slicing algorithm’s efficiency with respect to slice isolation is related to the ability of meeting individual slice requirements. However, mostly an aggregated slice performance guarantee is considered instead of per user guarantees. Hence, state-of-the-art approaches might not always provide the satisfaction of all users within a slice. Indeed, our results demonstrate that if user requirements within a slice are not included in the RAN slicing algorithm, the per user quality-of-service (QoS) may not be fulfilled. In this paper, we investigate the definition of slice isolation as the ability to satisfy individual users’ throughput within slices, in a frequency selective, multi-cell wireless scenario with focus on maximizing slices’ throughput. Our problem is tackled with a Lyapunov optimization approach, which proves to always achieve slice isolation. Our results show that our solution does not only achieve 100% user QoS guarantees compared to 50% achieved in the state-of-the-art, but also doubles the throughput with increasing number of BSs.
Gender Gaps in Total Factor Productivity: The Case of Manufacturing SMEs in Ghana

This paper provides evidence on the relative productivity differences between female-owned and male-owned firms in a developing country. We rely on data from a survey of small and medium manufacturing firms in the main industrial hubs of Ghana. We apply quantile regression and decomposition techniques to estimate the productivity gap and identify the mechanism behind the gap at the mean and selected percentiles. Our preferred estimation shows that female-owned firms are more productive at the lower tail of productivity distribution, but less productive at the mean and upper tails. Compositional effects explain the productivity gaps at the lower end of the distribution whilst structural effects are the primary sources of gaps at the upper tail of firm productivity. Finally, we do not find evidence of productivity gaps in female-dominated sectors, though these sectors tend to have lower average productivity.
Genetics, Immunity and Nutrition Boost the Switching from NASH to HCC

Nonalcoholic fatty liver disease (NAFLD) is the leading contributor to the global burden of chronic liver diseases. The phenotypic umbrella of NAFLD spans from simple and reversible steatosis to nonalcoholic steatohepatitis (NASH), which may worsen into cirrhosis and hepatocellular carcinoma (HCC). Notwithstanding, HCC may develop also in the absence of advanced fibrosis, causing a delayed time in diagnosis as a consequence of the lack of HCC screening in these patients. The precise event cascade that may precipitate NASH into HCC is intricate and it entails diverse triggers, encompassing exaggerated immune response, endoplasmic reticulum (ER) and oxidative stress, organelle derangement and DNA aberrancies. All these events may be accelerated by both genetic and environmental factors. On one side, common and rare inherited variations that affect hepatic lipid remodeling, immune microenvironment and cell survival may boost the switching from steatohepatitis to liver cancer, on the other, diet-induced dysbiosis as well as nutritional and behavioral habits may furtherly precipitate tumor onset. Therefore, dietary and lifestyle interventions aimed to restore patients’ health contribute to counteract NASH progression towards HCC. Even more, the combination of therapeutic strategies with dietary advice may maximize benefits, with the pursuit to improve liver function and prolong survival.
STAT1/SOCS1/3 Are Involved in the Inflammation-Regulating Effect of GAS6/AXL in Periodontal Ligament Cells Induced by Porphyromonas gingivalis Lipopolysaccharide In Vitro

Periodontitis involves chronic inflammation of the tissues around the teeth caused by plaque and the corresponding immune response. Growth arrest-specific protein 6 (GAS6) and AXL receptor tyrosine kinase (AXL) are known to be involved in inflammatory diseases, while signal transducer and activator of transcription-1 (STAT1) and suppressor of cytokine signaling (SOCS) are related to inflammatory processes. Moreover, miRNA34a directly targets AXL to regulate the AXL expression. However, the specific roles of GAS6 and AXL in periodontitis remain unclear. This study was designed to explore the effect and mechanism of AXL on the expression of inflammatory cytokines induced by Porphyromonas gingivalis lipopolysaccharide (P. gingivalis LPS) in human periodontal ligament cells (hPDLCs). The effects of different concentrations of P. gingivalis LPS on the expression of GAS6/AXL in hPDLCs were observed. Additionally, the effect of LPS on AXL was investigated by transfection of the miRNA34a inhibitor. AXL was knocked down or overexpressed to observe the release of inflammatory cytokines interleukin- (IL-) 8 and IL-6. The results showed that the expression levels of GAS6 and AXL decreased after P. gingivalis LPS infection. Transfection of a miR-34a inhibitor to hPDLCs demonstrated a role of miR-34a in the downregulation of AXL expression induced by LPS. Moreover, AXL knockdown or overexpression influencing the expression of IL-8 and IL-6 was investigated under LPS stimulation. AXL knockdown decreased the expression of STAT1 and SOCS1/3. Overall, these results demonstrate that AXL inhibits the expression of LPS-induced inflammatory cytokines in hPDLCs and that STAT1 and SOCS1/3 are involved in the regulation of inflammation by GAS6/AXL.
A Prospective Cohort Study of Biomarkers in Squamous Cell Carcinoma of the Anal Canal (SCCAC) and their Influence on Treatment Outcomes

Background: Although Chemoradiation (CRT) is the curative treatment for SCCAC, many patients present primary resistance. Since it is a rare tumor, response predictors remain unknown. Methods: We performed a prospective cohort study to evaluate biomarkers associated with CRT response, progression-free survival (PFS), and overall survival (OS). The primary endpoint was response at 6 months (m). Tumor DNA and HPV were analyzed by next-generation sequencing, while KI-67 and PD-L1 by immunohistochemistry in tumor tissue. Results: Seventy-eight patients were recruited between October/2011 and December/2015, and 75 were response evaluable. The median age was 57 years, 65% (n=49) were stage III and 12% (n=9) were HIV positive (HIV+). At 6m, 62.7% (n=47) presented CR. On multivariate analyses, stage II patients were 4.7 more likely to achieve response than stage III (OR, 4.70; 95%CI, 1.36-16.30; p=0.015). HIV+ was associated with a worse response (OR, 5.72; 95%CI, 2.5-13.0; p<0.001). 5-year PFS and OS rates were 63.3% and 76.4%, respectively, with a median follow up of 66m. On multivariate analyses, older age (HR 1.06, p=0.022, 95%IC 1.01-1.11) and absence of CR at 6m (HR 3.36, p=0.007, 95%IC 1.39-8.09) were associated with inferior OS. The 5-year OS rate was 62.5% in HIV+ group compared to 78% among HIV- pts, although this difference was not statistically significant (p=0.4). PIK3CA, MET and TP53 mutations, HPV, Ki-67 expression, and PD-L1 expression, were not associated with PFS and OS. Conclusions: Clinical stage III and HIV+ were associated with worse response to CRT at 6m. The absence of CR was the main factor associated with poor 5-year OS.
Drivers and Environmental Impacts of Vegetation Greening in a Semi-Arid Region of Northwest China since 2000

The dynamics of terrestrial vegetation have changed a lot due to climate change and direct human interference. Monitoring these changes and understanding the mechanisms driving them are important for better understanding and projecting the Earth system. Here, we assessed the dynamics of vegetation in a semi-arid region of Northwest China for the years from 2000 to 2019 through satellite remote sensing using Vegetation Index (VI) data from the Moderate Resolution Imaging Spectroradiometer (MODIS), and analyzed the interannual covariation between vegetation and three climatic factors—air temperature, precipitation, and vapor pressure deficit (VPD)—at nine meteorological stations. The main findings of this research are: (1) herbaceous land greened up much more than forests (2.85%/year vs. 1.26%/year) in this semi-arid region; (2) the magnitudes of green-up for croplands and grasslands were very similar, suggesting that agricultural practices, such as fertilization and irrigation, might have contributed little to vegetation green-up in this semi-arid region; and (3) the interannual dynamics of vegetation at high altitudes in this region correlate little with temperature, precipitation, or VPD, suggesting that factors other than temperature and moisture control the interannual vegetation dynamics there.
Reframing How Grading Affects and Shapes Students’ Self-Worth in Christian Higher Education

Abstract Academic achievement has too often been a metric by which students define their self-worth. For some students, this focus manifests itself through perfectionism, attaining high grades, and overvaluing extrinsic learning rewards. Students who consider their self-worth to be contingent upon their academic performance often suffer from withdrawal, stress, depression, and anxiety. The external and internal pressures placed upon students regarding academic achievement can be devastating. Recent criticisms of grading, its efficacy, and inconsistencies might lead postsecondary educators to reconsider how they assess and communicate competency to their students. Christian institutions of higher education in particular have unique opportunities to speak to students’ perceptions of their identity in ways that reframe the impacts and effects of grading on personal well-being and sense of self-worth. This article serves as a call to action for Christian universities to instill a more robust understanding of Christian identity and the imago Dei concerning how and where students find their self-worth—in whom they find their worth, rather than in what.
Impact of Fetal Growth Restriction on the Neonatal Microglial Proteome in the Rat

Microglial activation is a key modulator of brain vulnerability in response to intra-uterine growth restriction (IUGR). However, the consequences of IUGR on microglial development and the microglial proteome are still unknown. We used a model of IUGR induced by a gestational low-protein diet (LPD) in rats. Microglia, isolated from control and growth-restricted animals at P1 and P4, showed significant changes in the proteome between the two groups. The expression of protein sets associated with fetal growth, inflammation, and the immune response were significantly enriched in LPD microglia at P1 and P4. Interestingly, upregulation of protein sets associated with the oxidative stress response and reactive oxygen species production was observed at P4 but not P1. During development, inflammation-associated proteins were upregulated between P1 and P4 in both control and LPD microglia. By contrast, proteins associated with DNA repair and senescence pathways were upregulated in only LPD microglia. Similarly, protein sets involved in protein retrograde transport were significantly downregulated in only LPD microglia. Overall, these data demonstrate significant and multiple effects of LPD-induced IUGR on the developmental program of microglial cells, leading to an abnormal proteome within the first postnatal days.
Nitrogen Oxides Emissions, Chemistry, Deposition, and Export Over the Northeast United States During the WINTER Aircraft Campaign

We examine the distribution and fate of nitrogen oxides (NOx) in the lower troposphere over the Northeast United States (NE US) using aircraft observations from the Wintertime INvestigation of Transport, Emissions, and Reactivity (WINTER) campaign in February–March 2015, as well as the GEOS‐Chem chemical transport model and concurrent ground‐based observations. We find that the National Emission Inventory from the U.S. Environmental Protection Agency is consistent with WINTER observations of total reactive nitrogen (TNOy) to within 10% on average, in contrast to the significant overestimate reported in past studies under warmer conditions. Updates to the dry deposition scheme and dinitrogen pentoxide (N2O5) reactive uptake probability, ɣ(N2O5), result in an improved simulation of gas‐phase nitric acid (HNO3) and submicron particulate nitrate (pNO3−), reducing the longstanding factor of 2–3 overestimate in wintertime HNO3 + pNO3− to a 50% positive bias. We find a NOx lifetime against chemical loss and deposition of 22 hr in the lower troposphere over the NE US. Chemical loss of NOx is dominated by N2O5 hydrolysis (58% of loss) and reaction with OH (33%), while 7% of NOx leads to the production of organic nitrates. Wet and dry deposition account for 55% and 45% of TNOy deposition over land, respectively. We estimate that 42% of the NOx emitted is exported from the NE US boundary layer during winter, mostly in the form of HNO3 + pNO3− (40%) and NOx (38%).
Role of emotional intelligence in job performance of healthcare providers working in public sector hospitals of Pakistan

Objective. To determine the association between emotional intelligence (EI) and job performance (JP) of health care providers (HCPs). Methods. Healthcare professionals from various hospitals were chosen for a crosssectional study. The survey was conducted using a three-part questionnaire including the demographic profile, Wong and Law Emotional Intelligence (EI) Scale, and an individual work performance (JP) questionnaire. The relationship of predictor variables on JP was sought by applying Chi-square test and multiple regression analysis. Results. About 43.3% of the 50.8% of participants who scored well on the EI scale also scored high on the JP scales. The remaining 7.5% had an unsatisfactory JP. From the 22.8% of respondents who also scored low on EI scales, about 20% scored low on the JP scale. Significant relationship between EI and JP was found at a p-level of 0.05 (2 tailed). Emotional intelligence (B=0.57, p-<0.05) positively predicted job performance whereas difficulties faced while performing job (B=-0.81, p= <.005), beds under supervision (B=0.09, p=<0.05), dual practice (B=-0.04, p=<0.05) and weekly off days (B=0.04, p<0.05) have no significant effect on job performance. Conclusions. Subjects with high EI on the WLEIS were good at their jobs and scored well on the IWPQ scale, implying that as an individual's EI rises, so will his or her JP.
Time-resolved PIV measurement of influence of upstream roughness on separated and reattached turbulent flows over a forward-facing step

This study reports an experimental investigation of the effects of upstream roughness on a low Reynolds number turbulent boundary layer over a forward-facing step. Two types of upstream roughness were investigated, including a transitionally rough 16-grit sandpaper (ks+ ≈ 69) and fully rough staggered cubes (ks+ ≈ 500). A two-dimensional two-component time-resolved particle image velocimetry (2D-2C TR-PIV) method was used to measure the time-averaged mean velocities, Reynolds stresses, temporal auto-correlations and frequency spectra of the flow field to quantify the influence of upstream roughness on the downstream evolution of the turbulence over the step. The results indicate that upstream roughness decreased the vortex shedding frequency. Roughness also decreased the reattachment length by enhancing the streamwise turbulence intensity level, reducing the magnitude of backflow and suppressing the vortex shedding frequency in comparison to the smooth wall. In the recirculation region, upstream roughness.
Routes of Administration of Illicit Drugs among Young Swiss Men: Their Prevalence and Associated Socio-Demographic Characteristics and Adverse Outcomes

The prevalence of different routes of administration (ROAs) of illicit drugs other than cannabis was examined in young Swiss men, in addition to the association between socio-demographics and adverse outcomes and particular ROAs. Our sample consisted of 754 men (mean age = 25.4 ± 1.2 years) who participated in the Cohort Study on Substance Use Risk Factors and reported using any of 18 illicit drugs over the last 12 months. Prevalence estimates were calculated for oral use, nasal use, smoking, injecting, and other ROAs. Associations between ROAs and socio-demographics and adverse outcomes (i.e., alcohol use disorder (AUD), suicidal ideations, and health and social consequences) were calculated for using single versus multiple ROAs. The most prevalent ROA was oral use (71.8%), followed by nasal use (59.2%), smoking (22.1%), injecting (1.1%), and other ROAs (1.7%). Subjects’ education, financial autonomy, and civil status were associated with specific ROAs. Smoking was associated with suicidal ideations and adverse health consequences and multiple ROAs with AUD, suicidal ideations, and health and social consequences. The most problematic pattern of drug use among young adults appears to be using multiple ROAs, followed by smoking. Strategies to prevent and reduce the use of such practices are needed to avoid adverse outcomes at this young age.
Technical Note: Data assimilation and autoregression for using near-real-time streamflow observations in long short-term memory networks

Abstract. Ingesting near-real-time observation data is a critical component of many operational hydrological forecasting systems. In this paper we compare two strategies for ingesting near-real-time streamflow observations into Long Short-Term Memory (LSTM) rainfall-runoff models: autoregression (a forward method) and variational data assimilation. Autoregression is both more accurate and more computationally efficient than data assimilation. Autoregression is sensitive to missing data, however an appropriate (and simple) training strategy mitigates this problem.
Chlorogenic Acid Decreases Glutamate Release from Rat Cortical Nerve Terminals by P/Q-Type Ca2+ Channel Suppression: A Possible Neuroprotective Mechanism

The glutamatergic neurotransmitter system has received substantial attention in research on the pathophysiology and treatment of neurological disorders. The study investigated the effect of the polyphenolic compound chlorogenic acid (CGA) on glutamate release in rat cerebrocortical nerve terminals (synaptosomes). CGA inhibited 4-aminopyridine (4-AP)-induced glutamate release from synaptosomes. This inhibition was prevented in the absence of extracellular Ca2+ and was associated with the inhibition of 4-AP-induced elevation of Ca2+ but was not attributed to changes in synaptosomal membrane potential. In line with evidence observed through molecular docking, CGA did not inhibit glutamate release in the presence of P/Q-type Ca2+ channel inhibitors; therefore, CGA-induced inhibition of glutamate release may be mediated by P/Q-type Ca2+ channels. CGA-induced inhibition of glutamate release was also diminished by the calmodulin and Ca2+/calmodilin-dependent kinase II (CaMKII) inhibitors, and CGA reduced the phosphorylation of CaMKII and its substrate, synapsin I. Furthermore, pretreatment with intraperitoneal CGA injection attenuated the glutamate increment and neuronal damage in the rat cortex that were induced by kainic acid administration. These results indicate that CGA inhibits glutamate release from cortical synaptosomes by suppressing P/Q-type Ca2+ channels and CaMKII/synapsin I pathways, thereby preventing excitotoxic damage to cortical neurons.