Miracle-dz/UniFAR-FTUs huggingface dataset:
Running head: Epicardial cells and heart regeneration HUMAN EMBRYONIC STEM CELL-DERIVED EPICARDIAL CELLS AUGMENT CARDIOMYOCYTE-DRIVEN HEART REGENERATION

The epicardium and its derivatives provide trophic and structural support for the developing and adult heart. Here we tested the ability of human embryonic stem cell (hESC)-derived epicardium to augment the structure and function of engineered heart tissue (EHT) in vitro and to improve efficacy of hESC-cardiomyocyte grafts in infarcted athymic rat hearts. Epicardial cells markedly enhanced the contractility, myofibril structure and calcium handling of human EHTs, while reducing passive stiffness compared to mesenchymal stromal cells. Transplanted epicardial cells formed persistent fibroblast grafts in infarcted hearts. Co-transplantation of hESCderived epicardial cells and cardiomyocytes doubled graft cardiomyocyte proliferation rates in vivo, resulting in 2.6-fold greater cardiac graft size, simultaneously augmenting graft and host vascularization. Importantly, co-transplantation improved systolic function compared with hearts receiving either cardiomyocytes alone, epicardial cells alone or vehicle. The ability of epicardial cells to promote cardiac graft size and function make them a promising adjuvant therapeutic for cardiac repair.
Improved Rate Model of Temperature-Dependent Development by Arthropods

We proposed two improvements to the Logan model of temperature-dependent development. We first eliminated a redundant parameter (modification 1) then incorporated an intercept parameter (modification2), thereby resolving the inability of the original model to estimate a low-temperature developmental threshold. The three model versions were compared using temperature-dependent developmental rates in six insect species (a total of 11 life stages). The original model and modification 1 produced identical curves. In 10 of the 11 cases, modification2 had the highest r2 and the least estimation bias.
Le Basi Anatomiche Dei Rapporti Nutritivi Tra Pianta Madre, Seme Ed Embrione

Abstract The anatomical basis of the nutritive relationships between mother plant, seed, and embryo. — The morphology and anatomy of the fruits and seeds of the Angiosperms show a great variety of structures and adaptments, even within the same family, and one must be cautious in drawing generalized conclusions. If we first examine the ovary we see that the single carpel receives three vascular traces from which the three main bundles originate, a dorsal and two ventral ones, all more or less reduced. Except in the case of laminar placentation the ovule traces are connected to the ventral vascular system, but often the entire vascular system of the ovary is anastomosed and therefore reticular. However especially when the placentae are at the centre or at the basis of the ovary, it is possible to detect a tendency towards a separation between the vascular system of the ovarian wall and that of the placentae. The ovular bundle runs through the funicle reaching the chalaza, where it can either end or continu.
Three Novel Soybean Germplasms with Unique Fatty Acid Composition using Multiple Mutant Alleles

Three soybean [Glycine max (L.) Merr. ] germplasms were previously developed for unique fatty acid content: LPKKC-3 has fap1 and sop1 alleles for reduced palmitic acid, HPKKC-7 has fap2 and fapx alleles for elevated palmitic acid and DHL has the ol allele for elevated oleic acid, and fan and fanxa alleles for reduced linolenic acid. If these loci are independently inherited, soybean germplasms with useful combinations of these fatty acids could be developed that would result in a novel oil quality of great value for the food industry. Crosses were made between DHL and LPKKC-3, and DHL and HPKKC-7. The data from F2 seed and F2 progeny of DHL X LPKKC-3 indicated that the loci controlling reduced palmitic acid (fap1 and sop1) were independently inherited from the locus controlling elevated oleic acid (ol), and the loci controlling reduced linolenic acid (fan and fanxa). Thus, the germplasm (LPDHL) with 4.0% palmitic, 51.0% oleic and 2.9% linolenic acids was easily developed. The data from F2 seeds and F2 progeny of DHL X HPKKC-7 indicated that the loci controlling elevated palmitic acid (fap2 and fapx), and reduced linolenic acid (fan and fanxa) were independently inherited. The locus controlling elevated oleic acid (ol) was also distinctly segregated but the contents of oleic acid were found to be reduced due to the presence of loci for elevated palmitic acid. Thus, one germplasm (HPLL) with 22.5% palmitic acid and 2.7% linolenic acid, and another germplasm (MHPDHL) with 17.1% palmitic acid, 41.8% oleic and 2.9% linolenic acids were developed.
Language Teachers and Their Perceptions of the Impact of "Short-Term" Study Abroad Experiences on Their Teaching Practice

The benefits of study abroad for language teachers have received little attention in the research literature and yet such sojourns are potentially valuable professional learning opportunities. This article presents results of a study examining the reported impact of a short-term study abroad on teachers’ teaching practice, on their confidence in language teaching, and understanding of student language learning. Whereas teacher study abroad studies have tended to focus on groups of teachers traveling to common destinations for a uniform period to study the same language, this paper contributes by examining the potential of study abroad experiences for improving language teacher practice from the perspective of a diverse range of teachers, travelling to different countries, and teaching different languages. Teachers reported that the sojourns resulted in gains in aspects of teaching practice, and in teacher confidence. However, there was also a sense of missed opportunities, in particular as regards developing an increased understanding of student language learning.
Roughness effect on the efficiency of dimer antenna based biosensor

The fabrication process of nanodevices is continually improved. However, most of the nanodevices, such as biosensors present rough surfaces with mean roughness of some nanometers even if the deposition rate of material is better and better controlled. The effect of roughness on performance of biosensors was fully addressed for plane biosensors and gratings, but rarely addressed for biosensors based on Local Plasmon Resonance. The purpose of this paper is to evaluate numerically the influence of nanometric roughness on the efficiency of a dimer nano-biosensor (two levels of roughness are considered). Therefore, we propose a general numerical method, that can be applied to any other nanometric shape, to take into account the roughness in a three dimensional model. The study focuses on both the far-field, which corresponds to the experimental detected data, and the near-field, responsible for exciting and then detecting biological molecules. The results suggest that the biosensor efficiency is highly sensitive to the surface roughness. The roughness can produce important shifts of the extinction efficiency peak and a decrease of its amplitude resulting from changes in the distribution of near-field and absorbed electric field intensities.
Distribution of Overwintering Russian Wheat Aphid (Homoptera: Aphididae) in Furrow-Irrigated Small Grains in Western Colorado

The Russian wheat aphid, Diuraphis noxia (Mordvilko), was sampled in spring 1989, fall 1989, and spring 1990 to document distribution and density within fields of small grains in western Colorado. In spring 1989, aphids were found throughout fields with east-west furrows, but plants located on the south-facing slope of the irrigation beds had the highest infestations. In fields with north-south furrows, aphids were found only on plants on south-facing slopes of irrigation ditches at either end of the field. In fall 1989, there was a higher density of aphids on the south-facing slopes of beds than at other sample sites in fields with east-west furrows whereas they were evenly distributed over beds in fields with north-south furrows. Infestations increased on the south slopes and middle of beds in fields with east-west furrows during the winter of 1989-1990 but remained unchanged in fields with north-south furrows. Temperatures were higher and heat unit accumulations greater on the south slope of the bed than at any other site.
Effects of Sulfur Application on Enzyme Activities in Relation to the Ascorbate-Glutathione Cycle and the Occurrence of Internal Browning in Raphanus Roots

The occurrence of internal browning (IB) was more frequent in sublimed sulfur applications at the levels of 0 and/or 10 g·m−2; however, an increase in the severity of IB symptoms was not nearly so marked when sublimed sulfur was applied, approximately at the level of 30 g·m−2. The activities of L-phenylalanine ammonia-lyase (PAL) and polyphenol oxidase (PPO) became low in proportion to the increasing application of sublimed sulfur from 0 to 30 g·m−2. Conversely, a pronounced increase in ascorbate peroxidase (APX), dehydroascorbate reductase (DHAR), and glutathione reductase (GSHR) activities were detected with a larger amount of this element. These observations suggest that the application of sublimed sulfur resulted in an increase in H2O2 decomposing capacity via the ascorbate-glutathione cycle, so that IB symptoms seldom intensified because of inactivation of the peroxide detoxifying pathway derived from PPO.
Signs at the Top: Habitat Features Influencing Snow Leopard Uncia uncia Activity in Sagarmatha National Park, Nepal

Abstract We used logistic regression to examine factors that affected the spatial distribution of sign (scrapes, feces, footprints, spray or scent marks, and rubbing sites) in a newly reestablished population of snow leopards (Uncia uncia) in Sagarmatha (Mount Everest) National Park, Nepal. Our results indicate that terrain and human activity were the most important factors determining the spatial distribution of leopard activity, whereas presence of their major prey species (Himalayan tahr [Hemitragus jemlahicus]) had only a moderate effect. This suggests that localities at which these animals are active represent a trade-off between suitable habitat and avoidance of potential risk from anthropogenic origins. However, the influence of prey presence was likely underestimated because of the methodology used, and likely weighed in the trade-off as well.
Preparation, Thermostability, and Degradation In Vitro of Polylactides Bearing Porphyrins

Polylactide (PLA) bearing hemin coupling moieties was prepared by a reaction between the two carboxylic groups of hemin and amino groups of amino-terminated PLA and characterized by UV-Vis, IR, and 1H NMR spectra and gel permeation chromatography. Blank microparticles and microparticles loaded with bovine serum albumin (BSA), both of PLA bearing hemin, were prepared and characterized by solid UV-Vis spectra and thermogravimetric analysis (TGA). The effects of hemin on thermostability and degradation of microparticles of PLA were studied using TGA and a degradation experiment in vitro. These experiments showed that the introduction of porphyrin rings into PLA molecules led to the reduction of thermostability, a greater degradation of the polymer than the original polymer under the same condition in vitro, and a higher ability of the polymer binding to BSA molecules. These results should be of use in biodegradable polymer design and photodynamic therapy studies of porphyrin derivatives.
STUDENT’S PERCEPTION ABOUT INCREASING PRODUCTIVITY DURING DISSECTION HALL TIME- A QUESTIONNAIRE BASED STUDY

Corresponding Author: Palak, Demonstrator, Department of Anatomy, Government Medical College and Hospital, Chandigarh, India. Contact no: 9876233767 E-Mail: palakchhabra48 @gmail.com Introduction:A first year medical student spends around 600 hours in anatomy. Time tested cadaveric dissection is considered as the heart of anatomy learning by young students as well as eminent medical professionals. The reason for the introduction of other sources being constrained time schedule with growing internet generation which forces the anatomy faculty to blend in to make the subject interesting. Aims and Objectives: The aim of the study was to quantify student’s perception on the cadaveric teaching and their view on integration of other tools in dissection hall, also assessing different ways to increase their productivity in dissection hall time. Material and methods: A cross-sectional questionnaire-based survey was conducted in the Department Of Anatomy, Government Medical College, Chandigarh, India on 27 and 28th of May 2019. A predesigned 11 item questionnaire was circulated to 101 outgoing first-year MBBS students out of which 93 students participated. Results and conclusion: Majority of the students(90%) feel that there cannot be any replacement for actual cadaveric dissection. the maximum students (84%) preferred you tube videos as compared to mobile applications (6%) thereby stating that these apps do not aid much in their learning.
Universiteit Leiden Opleiding Informatica

We develop a method for constructing non-deterministic ﬁnite automata (NFA) for Kleene algebra with tests (KAT) expressions for use in program veriﬁcation. This method uses partial derivatives to construct NFAs. The first set of an expression determines which derivatives to compute, thus reducing the computation steps. Our NFAs are the ﬁrst ﬁnite automata to have the same complexity as their Kleene algebra counterparts. To check the constructed automata for equivalence, we use a bisimulation up-to congruence method. This allows for checking equivalence ‘on-the-ﬂy’ without the need of prior determinization.
A Corpus of Sentence-level Annotations of Local Acceptability with Reasons

News editorials are presented with arguments of different quality, which readers may or may not accept as presented. In this work, we present a corpus of news editorials with sentence-level annotations of local acceptability and a set of related attributes, where the annotators also provided detailed reasons in natural language for each attribute. The annotations were performed in both in-house and crowdsourcing environments. In total, 105 news editorials were annotated for 3,591 sentences, with an average of four annotations from different annotators per sentence, resulting in about 14K sentence-level annotations with detailed reasons in natural language (in total 121K tokens written in 1K aggregated hours). We analyze the reasons to see why given information is accepted or rejected, examine the correlation among the attributes, and compare our annotation result against argumentation strategies. This is the ﬁrst corpus to provide sentence-level annotations with attributes such as local acceptability, which we argue is critical for a ﬁne-grained and advanced analysis of argumentation quality.
Where the truth lies: how sampling implications drive deception without lying

Efficient communication leaves gaps between message and meaning. Interlocutors, by reasoning about how each other reasons, can help to fill these gaps. To the extent that such meta-inference is not calibrated, communication is impaired, raising the possibility of manipulation for deceptive ends. We examined how people reason when acting as the perpetrator or target of deception across two related experiments. Importantly, the nature of the task precluded outright lying. Thus, deception required withholding information or providing data that was factually correct but nonetheless misleading. We find evidence for two distinct patterns of behaviour. One group of people appear to make assumptions about communicative intent based on context and message content. Senders in this group were more likely to mislead, and receivers were more effectively misled. A second group of people appeared to adopt a more defensive stance, displaying the same cautious approach in all situations. We explain this behaviour using a computational account of the kinds of inferences required by both receiver and sender. These distinct patterns arise from different assumptions about the generative process behind communication.
The first Bulgarian allergen extract from Ambrosia artemisiifolia L.

Ambrosia artemisiifolia L. is a leading cause of allergies in many countries. In the last decade it has appeared and spread in Bulgaria as well. The aims of this study was to collect pollen from ragweed plants in Bulgaria, prepare the first Bulgarian ragweed allergen, and characterize it. The new allergen was studied in parallel with two other ragweed pollen extracts from the USA and Russia. The protein profile was studied through isoelectric focusing, and the total allergen activity was studied by a skin prick test and a basophil activation test. The proteins of the studied extracts were concentrated in the pI region 3.5–5.5 with an identical band number and location. The allergens showed similar total allergen activity in vivo:14/81 tested patients (17.3 %) were SPT positive either to a single ragweed extract or to all three. The allergens had identical histogram profiles and caused basophil degranulation above the test cut-off. The analysis of the flow cytometry results by parallel line bioassay shows linear dose-response relation between the extracts. The observed immunological properties of the Bulgarian allergen from Ambrosia artemisiifolia provide a possibility to use this product for a reliable diagnosis and effective specific immunotherapy of ragweed allergy in our country.
TNF-Alpha and IL-1Beta-Mediated Regulation of MMP-9 and TIMP-1 in Human Glomerular Mesangial Cells

Background: Renal cells such as mesangial cells are known to secrete metalloproteinases that are capable of degrading the constituents of the glomerular basement membrane (GBM). Disruption of the GBM via cytokine-induced alterations in matrixmetalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) may be an important mechanism in the renal disease process. In renal disease, both resident renal cells and infiltrating immune cells are capable of secreting pro-inflammatory cytokines including tumour necrosing factor-α (TNFα) and interleukin-1β (IL-1β). In this study, we examine the potential of these cytokines to alter levels of MMPs and TIMPs in human mesangial cells. Methods: The T-HMC human mesangial cell line was cultured in RPMI 1640 containing 5% serum. Cells at confluency were serum starved for 24 h prior to exposure to TNF-α (0.1–100 ng/ml) or IL-1β (0.1–100 ng/ml) or a combination of both for 48 h. Activity of MMP-9 was examined by gelatin zymography and TIMP-1 expression was analysed by Western blotting. Results: TNF-α but not IL-1β resulted in a dose-dependent increase in the latent form of MMP-9 and a decrease in TIMP-1 production. Co-treatment with IL-1β had no effect on the induction of MMP-9 but increased the inhibition of TIMP-1 in the presence of TNF-α. Inhibition of PKC provided evidence of the importance of this pathway in mediating the TNF-α-induced suppression of TIMP-1. Activation of the ERK 1/2 MAPK mediated both the upregulation of MMP-9 and the inhibition of TIMP-1 following TNF-α treatment. p38 MAPK activation was also found to be involved in the TNF-α-stimulated MMP-9. Conclusion: The cytokine TNF-α causes different effects on human mesangial MMP-9 and TIMP-1 expression which are mediated through the TNF-RI, and the different signalling pathways of PKC, ERK 1/2 and p38 MAPK. This suggests an important role for pro-inflammatory cytokines in renal disease progression.
Thirty Years of Cassava Breeding for Productivity—Biological and Social Factors for Success

The Centro Internacional de Agricultura Tropical (CIAT, head-quartered in Colombia) established a cassava (Manihot esculenta Crantz) breeding program in the beginning of the 1970s with the aim of extending the Green Revolution success to less privileged sectors of the tropical populations. The initial decade was mainly dedicated to the collection of germplasm and generation of basic breeding materials. The later decades were devoted to applied breeding in collaboration with international and national programs In Latin America, Asia, and Africa. This paper focuses on the basic breeding at CIAT/Colombia (CIAT/HQ), applied breeding at CIAT/Thailand (CIAT/Thai), and distribution and selection of improved materials with many collaborators in Asia. Fresh root yield of populations was improved by >100% and root dry matter content by >20%. The national program collaborators used these populations to develop many improved cultivars in many countries. The biological factors considered as critical for this successful breeding effort were as follows: inclusion of a broad base of genetic variability obtained in the center of crop origin and diversification; evaluation of breeding materials under diverse environmental conditions including high stress environments; and a clear understanding of the different operational principles at different stages of breeding advancement, as illustrated by the emphasis on harvest index in selection within populations and on biomass in population building. The understanding of crop germplasm being a common heritage and the determination of agricultural scientists to use this for the welfare of the neediest people were the social factors for the overall success.
Nutraceuticals to Treat Joint Pain as An Alternative to Non-Steroidal AntiInflammatory Drugs

What is an alternative to non-steroidal anti-inflammatory drugs for the treatment of joint pain? The Arthritis, Rheumatism, and Aging Medical information System estimates that adverse effects due to NSAIDs are associated with more than 100,000 hospitalizations and more than 16,000 deaths in the U.S. each year. Both nonselective and selective COX-2 inhibitors have now been shown to be associated with an increased risk for cardiovascular events. These studies, together with the outcomes of the recent US Food and Drug administration decision to require 'black box' warnings regarding potential cardiovascular risks associated with NSAIDs, suggest that the use of COX-2 inhibitors as the sole strategy for gastroprotection in patients with arthritis and other pain syndromes must be reconsidered, particularly among those at risk for cardiovascular events [1].
Mexican registry of pulmonary hypertension

a Executive Committee, Mexico b National Coordinator, Mexico c Instituto Nacional de Cardiologia ‘‘Ignacio Chavez’’, Mexico d Instituto de Cardiologia y Medicina Vascular, TEC Salud, San Pedro Garza García, Mexico e Centro de Investigación Biomédica del Hospital Zambrano Hellion, Escuela de Medicina, Tecnologico de Monterrey, Mexico f Hospital de Cardiología No 34, IMSS, Monterrey, Mexico g Hospital Mac Bernardette, Guadalajara, Mexico h Instituto Nacional de la Nutrición ‘‘Salvador Zubiran’’, Mexico i Centro Medico ABC, Mexico j Instituto de Seguridad y Servicios Sociales del Estado de Baja California, Mexico k Hospital Universitario ‘‘Dr. José E. González’’, Monterrey, Mexico l Hospital de Especialidades, Centro Médico Nacional de Occidente, IMSS, Guadalajara, Mexico m Centro Medico Nacional ‘‘20 de Noviembre’’ ISSSTE, Mexico