Miracle-dz/UniFAR-FTUs huggingface dataset:
Matrix metalloproteinase 9 gene promoter region -1562 C/T single nucleotide polymorphism increases the susceptibility to hypertensive disorders of pregnancy: a meta-analysis

Hypertensive disorders of pregnancy (HDP) encompass a group of diseases. Single nucleotide polymorphisms (SNPs) are common in the matrix metalloproteinase 9 (MMP9) genes. The objective of this studywas to analysewhether genetic polymorphisms inMMP9-1562 C/T alter the risk ofHDP. Studies published up toOctober 2019 across PubMed, ScienceDirect, SpringerLink, and China National Knowledge Infrastructure database were searched. Case-control or cohort studies involving subtypesofHDPanddistributionofgenotypes and/or alleles within MMP9-1562 C/T in both patients and controls were selected. Number of genotypes and/or alleles for MMP9-1562 C/T polymorphisms were obtained and analyzed using Stata so tware. Eight published reports including 1300 HDP patients and 1612 controls were included in the meta-analysis. Results showed that a variant genotype and allele of MMP9-1562 C/T increased the risk of HDP, with pooledOR 1.50 (95%CI 1.16--1.95, P = 0.002) and 1.36 (95% CI 1.15--1.61, P < 0.001). Subgroup analyses showed that the variant genotype and allele of MMP9-1562 C/T also had increased risk of preeclampsia (OR = 1.48, 1.32; 95% CI 1.18--1.86, 1.08--1.62; P = 0.001, 0.007) and gestational hypertension (OR = 2.23, 1.88; 95% CI 1.52-3.28, 1.33--2.65; P< 0.001,< 0.001) in the fixed-e fects models. This suggests that variant genotype (TT + TC) and allele (T) ofMMP9-1562 C/T are associated with susceptibility of HDP, especially preeclampsia and gestational hypertension.
Evidence of Alfvenic Poynting Flux as the Primary Driver of Auroral Motion During a Geomagnetic Substorm

Geomagnetic substorms are major energy transfer events where energy stored in the Earth's magnetotail is released into the ionosphere. Substorm phenomena, including auroral activities, earthward Poynting flux, magnetic field dipolarization, etc, have been extensively studied. However, the complex interplay among them is not fully understood. In a fortuitous event on June 7, 2013, the twin Van Allen Probes (separated by 0.4 h in local time) observed bursts of earthward Alfvenic Poynting flux in the vicinity of the plasma sheet boundary layer (PSBL). The Poynting flux bursts correlate with enhancements of auroral brightness around the footpoints of both spacecraft. This indicates a temporal and spatial correlation between the auroral brightening and Poynting flux bursts, and that the auroral motion is directly linked to the perpendicular expansion of the Alfven wave. These observations suggest that the Alfvenic Poynting flux is a primary driver for the auroral electron acceleration. Around the time of auroral brightening, a dipolarization was seen to propagate more than 4 h in local time during a 20 min period. The azimuthal phase speed of this dipolarization (2 deg/min) is too small to explain the azimuthal motion of the aurora (13.6 deg/min), but the dipolarization could be related to the generation of the Alfvenic Poynting flux through phase mixing at strong density gradients like those in the PSBL.
Determination of Clenbuterol in Animal Tissues by High Performance Liquid Chromatography

A high performance liquid chromatographic method with ultraviolet detection was developed for the determination of clenbuterol (CBL) in animal tissues. CBL was extracted with 3% metaphosphoric acid in the presence of dichloromethane. After adjustment of the pH of the extract to above 9.0, CBL was reextracted with n-hexane-ethyl acetate (1:1), followed by a Polyspher RP-18 clean-up procedure. The HPLC separation was carried out on an L-column ODS using 0.01M phosphate buffer (pH 3.5)-acetonitrile (7:3) as the mobile phase at flow rate of 0.9ml/min. Ultraviolet detection was operated at the wavelength of 209nm or 242nm. The recovery of CBL from tissues spiked at the level of 0. 2μg/g was 75.1-86.4%, and the detection limit was 0. 005μg/g.
Liquid Jet in Cross Flow Modeling

All key combustor performance & operability characteristics like emissions, exit profile, durability, LBO etc. have a dependence on spray quality. Hence it is important to accurately predict spray characteristics for accurate combustor modeling. In this paper, a CFD based liquid jet in cross flow spray modeling approach adopted at GE Aviation is presented. Liquid jet in cross flow is a complex phenomenon that broadly involves jet trajectory evolution, surface breakup, column fracture and dispersion of secondary droplet particles. A two-phase steady state Volume of Fluid (VOF) approach is used to predict the liquid jet trajectory. A combination of output from VOF and empirical correlations (Sallam et. al; Oda et. al) is used to predict droplet distribution that includes diameter, velocity components and mass flow rate. Surface breakup is modeled by injecting droplets along the leeward surface of the liquid jet with spanwise perturbation to capture the transverse spread. Jet column breakup is modeled by injecting droplets including effects of unsteady fluctuations empirically to mimic the column fracture behavior. Discrete particles are then transported in a lagrangian frame coupled with secondary breakup of droplets. This approach has been validated on a benchmark quality dataset with an average SMD (Sauter Mean Diameter) error of ∼6 microns and is being used on Gas Turbine combustor fuel-air mixing devices employing liquid jet in cross flow atomizers. © 2014 ASME
Stress, psychological disease, psychological well-being and personality in Italian firefighters compared to other working categories

Abstract This study analyzed the differences between firefighters and other working categories (urban policemen, employees in the service industry) in psychological well-being, anxiety, depression, personality and stress. Much research has evidenced that people who have to deal with emergencies are more subjected to psychological diseases. Our results showed that firefighters have lower levels of anxiety, depression, emotional instability and negative emotions in relation to urban policemen and employees. In addition, there are no significant differences in psychological well-being. Further research is necessary to define the specific psychological attitudes or traits which allow firefighters to deal with psychological disease and stress.
Prevalence of Rubella Immunity among Women Seeking Antenatal Care in a Tertiary Institution, South-South, Nigeria

Aims: To determine rubella sero-prevalence (IgG, IgM) and to describe its relation to sociodemographic data among pregnant women in a tertiary institution in Yenagoa, Bayelsa state, South-South, Nigeria. Original Research Article Egbagba et al.; JAMMR, 33(9): 30-37, 2021; Article no.JAMMR. 67357 31 Study Design: This was a descriptive cross sectional study. Place and Duration of Study: Department of Obstetrics and Gynaecology, Federal Medical Centre in Yenegoa, Bayelsa State, in South-South Nigeria between May 2020 and August 2020. Methodology: We included 398 women at various stages of pregnancy. An interviewer administered questionnaire was used to obtain socio demographic data. Ten ml of venous blood was then collected for serological assays. Analyses of samples were done using an in-vitro on-site rubella IgG/IgM rapid diagnostic assay. P value were kept at 0.05. Results: A total of 209 (53.0%) of the 398 women had a positive IgG antibodies. None (0.0%) of the women had positive IgM antibodies. There were no significant associations between respondents socio-demographic characteristics and rubella immunity as the probability values observed were greater than 0.05 (p>0.05). Conclusion: Our study shows a moderately high sero-prevalence of IgG antibodies amongst the participants studied. This indicates that rubella infection is endemic in Nigeria and requires further surveillance and control.
Ownership composition and intellectual capital disclosure: Indonesia as a case study

This study explores whether ownership structure (comprising ownership concentration, foreign, managerial, and institutional ownership) affects intellectual capital disclosure (ICD) in Southeast Asia’s largest stock market and Indonesia’s emerging economy. The sample includes 323 public firms listed on the Indonesia Stock Exchange (IDX) from seven industries between 2008 and 2017, or 2,634 firm-year observations. Data were analyzed using the ordinary least squares (OLS) regression with robust standard errors. The results show that ICD is positively related to ownership concentration. A negative and substantial relationship was found for both foreign and managerial ownerships, while the institutional ownership variable had a negative and insignificant impact. Overall, the results show robust conclusions regarding the impact of the ownership structure on ICD. The findings of this investigation could be taken into account by capital market authorities such as the Indonesia Stock Exchange (IDX) to raise awareness of intellectual capital and improve ICD practices. Acknowledgment The researchers are grateful for the valuable responses from two unnamed reviewers and discussion respondents at Mulawarman University. We also thank the Indonesia Stock Exchanges (IDX) and The Indonesia Capital Market Institute for providing the annual report.
Influence of different types of anesthesia on the inflammatory response in laparoscopic hysterectomy

The aim of the study was to evaluate the influence of different variants of anesthesia, including low-opioid (LOA) and opioid-free anesthesia (OFA), on the dynamics of the inflammatory response during laparoscopic hysterectomy. Materials and methods: 102 patients were randomly allocated into 3 groups: 37 women assigned to receive a standard opioid-based anesthesia (OBA group), 33 women – LOA group and 32 patients – OFA group. In the LOA group, the amount of fentanyl was halved and lidocaine infusion and ketamine were additionally infused during induction. In the OFA group, ketamine, lidocaine and dexmedetomidine were additionally infused instead of fentanyl. Results: Conducting a laparoscopic hysterectomy is accompanied by the activation of the inflammatory process and is manifested by an increase in the content of leukocytes and granulocytes, and a decrease in the number of lymphocytes, which is accompanied by an increase in the leukocyte index of intoxication. These changes were most significant in patients undergoing standard anesthesia. The activation of the inflammatory process is confirmed by an increase in the level of pro-inflammatory IL-6 in all groups from 28.8 % to 92.9 %, and it was most pronounced in patients who underwent LOA. In the same group, the greatest increase in the level of anti-inflammatory IL-10 was also noted, the level of which was 115.4 % higher (p=0.036) than in the control group. An increase in the content of the pro-inflammatory cytokine IL-6 in each group and a parallel increase in anti-inflammatory IL-10 in groups 2 and 3, with a simultaneous decrease in it in group 1 led to a significant increase in the IL-6 / IL-10 ratio in the control group. This indicator was significantly higher than in groups 2 and 3 by 42.3 % (p=0.043) and 52.7 % (p=0.041), respectively, while the IL-6 / IL-10 ratio in these groups was not differed from the initial state. Conclusion: Laparoscopic hysterectomy is accompanied by activation of the inflammatory process and is manifested by an increase in the content of leukocytes and granulocytes and a decrease in the number of lymphocytes, which is accompanied by an increase in the leukocyte index of intoxication. These changes were most significant in patients undergoing standard anesthesia. The use of LOA and OFA is accompanied by a lower activation of the inflammatory response in laparoscopic hysterectomy than in standard anesthesia, but requires further study
Low dose contrast media in step-and-shoot coronary angiography with third-generation dual-source computed tomography: feasibility of using 30 mL of contrast media in patients with body surface area <1.7 m2.

Background Reducing contrast media volume in coronary computed tomography angiography minimizes the risk of adverse events but may compromise diagnostic image quality. We aimed to evaluate coronary computed tomography angiography's diagnostic image quality while using 30 mL of contrast media in patients with a body surface area <1.7 m2. Methods This prospective study included patients who underwent coronary computed tomography angiography from May 2018 to June 2019. The patients were divided into a low-dose group, who received 30 mL of contrast media, and a routine-dose group, who received contrast media based on body weight. Patient characteristics, coronary computed tomography angiography results, and quantitative and qualitative image results were assessed and compared. Results In total, 103 patients with a body surface area <1.7 m2 were 53 in the low-dose group and 50 in the routine-dose group. Sex, age, body surface area, body weight, and heart rate were similar between the groups (P>0.05). A contrast media volume of 30±0 mL was used for the low-dose group, and 41.62±4.59 mL was used for the routine-dose group. The low-dose group's computed tomography values were significantly different from those of the routine-dose group (P<0.05). The radiologists demonstrated agreement regarding diagnostic image quality and accuracy (kappa =0.91 and 0.85, respectively). Conclusions Using 30 mL of contrast media for coronary computed tomography angiography in patients with a body surface area <1.7 m2 provided a suitable diagnostic image quality for coronary artery disease diagnosis. Although radiation doses were similar between the groups, the decreased contrast media volume was likely beneficial for the patients.
Gastrin-17 Combined with CEA, CA12-5 and CA19-9 Improves the Sensitivity for the Diagnosis of Gastric Cancer

Background Previous studies reported the utility of serum tumor markers (such as CEA, CA12-5 and CA19-9) and gastrin-17 in the diagnosis of gastric cancer (GC). However, the value of these serum markers for diagnosing GC is still under debate. In this study, we aimed to evaluate the effect of gastrin-17, CEA, CA12-5 and CA19-9 in the diagnosis of GC. Methods The level of CEA, CA12-5, CA19-9 and gastrin-17 was tested in 230 GC patients and 99 healthy people. The value of the four markers for diagnosing GC was analyzed. Results The positive rate of Gastrin-17, CEA, CA19-9 and CA12-5 was much higher in GC group (22.61%, 22.61%, 20.00% and 8.26%, respectively) than that of healthy control group (5.05%, 2.02%, 1.01% and 2.02%, respectively). The sensitivity of Gastrin-17, CEA, CA12-5 and CA19-9 in the diagnosis of GC was 22.61%, 22.61%, 6.96% and 20.00%, respectively, and the corresponding specificity was 94.95%, 97.98%, 98.99% and 98.99%, respectively. By using the optimal cut-off value derived from the area under curve (AUC) of receiver operating characteristic curve, the AUC of gastrin-17, CEA, CA12-5, CA19-9 increased to 0.72, 0.64, 0.61 and 0.65, respectively. After combining the four markers, the AUC increased to 0.79 (95% CI: 0.75–0.84), and the corresponding sensitivity and specificity were 65.22% (95% CI: 58.70–71.40%) and 84.85% (95% CI: 76.20–91.30%), respectively, which were significantly higher than those of separate markers (P < 0.05). Conclusion CEA, CA12-5, CA19-9 and gastrin-17 were all valuable in the diagnosis of GC, and gastrin-17 had the best diagnostic value among the four markers. Gastrin-17 combined with CEA, CA12-5 and CA19-9 could improve the diagnostic value of GC significantly. Prospective, multi-center studies are needed to validate our findings.
The Systematics of Chlorine, Lithium, and Boron and δ37Cl, δ7Li, and δ11B in the Hydrothermal System of the Yellowstone Plateau Volcanic Field

Chlorine, lithium, and boron are trace elements in rhyolite but are enriched in groundwater flowing through rhyolite because they tend to partition into the fluid phase during high‐temperature fluid‐rock reactions. We present a large data set of major element and δ37Cl, δ7Li, and δ11B compositions of thermal water and rhyolite from Yellowstone Plateau Volcanic Field (YPVF). The Cl/B, Cl/Li, δ37Cl (−0.2‰ to +0.7‰), and δ11B (−6.2‰ to −5.9‰) values of alkaline‐chloride thermal waters reflect high‐temperature leaching of chlorine, lithium, and boron from rhyolite that has δ37Cl and δ11B values of +0.1‰ to +0.9‰ and −6.3‰ to −6.2‰, respectively. Chlorine and boron are not reactive, but lithium incorporation into hydrothermal alteration minerals results in a large range of Cl/Li, B/Li, and δ7Li (−1.2‰ to +3.8‰) values in thermal waters. The relatively large range in δ7Li values of thermal waters reflects a large range of values in rhyolite. Large volumes of rhyolite must be leached to account for the chloride, lithium and boron fluxes, implying deep groundwater flow through rhyolite flows and tuffs representing Yellowstone's three eruptive cycles (∼2.1 Ma). Lower Cl/B values in acid‐sulfate waters result from preferential partitioning of boron into the vapor phase and enrichment in the near‐surface water condensate. The Cl/B, Cl/Li, δ7Li (−0.3‰ to +2.1‰), and δ11B (−8.0‰ to −8.1‰) values of travertine depositing calcium‐carbonate thermal waters which discharge in the northern and southern YPVF suggest that chlorine, lithium, and boron are derived from Mesozoic siliciclastic sediments which contain detrital material from the underlying metamorphic basement.
Dental Medicine Students Perception on the Effectiveness of Problem Based Learning (PBL) Class Using Online Learning Method

Background: The main concern of universities is regarding the quality and effectiveness of education. Atotal of 32 dentistry faculties in Indonesia have implemented Problem Based Learning (PBL) classes in theirlearning curriculum. Some dentistry faculties have actively used student-centered learning method, andare no longer teacher-centered. According to the results of the 2017 Indonesian Internet Service ProvidersAssociation, the prevalence for Indonesian (Undergraduate/Diploma) students as Internet users reached79.23%. Purpose: To describe the perception of Universitas Airlangga Faculty of Dental Medicine students on theeffectiveness of the Problem Based Learning (PBL) class using the Online Learning method.Method: Data was collected from the distribution of questionnaires to students of Universitas Airlangga,Faculty of Dental Medicine semesters 1, 3, 5, and 7. Then a descriptive statistical test was conducted.Results: The percentage of respondents who considered effective Problem Based Learning (PBL) classesusing online learning method was 52.4%, very effective at 5.8%, very ineffective at 2.9%, no opinion at14.6%, and ineffective at 24.3%. Conclusion: The majority of Universitas Airlangga Faculty of Dental Medicine students have an effectiveperception of the Problem Based Learning (PBL) class using the Online Learning method.
Pre-Attack Warning Behaviors of 20 Adolescent School Shooters: A Case Study Analysis

This study examines the pre-attack warning behaviors of adolescent school shooters in the US. We conducted 20 case studies of adolescent school shooters in the United States that committed non-fatal or fatal shootings on K-12 school grounds between 1999 and 2016. We investigate whether the school shooters displayed warning behaviors before the attack, who in the perpetrator’s life was aware of these warning behaviors, and what if any actions were taken in response. Given the emergence of online forms of communication, we also investigate how adolescent school shooters may variably communicate warning behaviors in online and offline contexts.
The study of phospholipid bilayer of cell membranes in leukocytes incubated with high concentrations of the food additive E407a

Aim: The aim of the study was to assess the impact of semi-refined carrageenan (E407a) on the hydrophobic region of phospholipid bilayer in cell membranes of leukocytes exposed to the solution with high concentrations of this food additive. Material and methods: Fluorescent probe (2-phenylphenanthro[9,10-d]-1,3-oxazole) was used to investigate the influence of E407a on the state of lipid bilayer in leukocytes extracted from rats and treated with a 5% solution of the food additive E407a during 4 hours. Results: The shapes of the probe fluorescence spectra did not differ in leukocytes of rats treated with the 5% solution of semi-refined carrageenan and white blood cells of control samples. Such findings suggest that exposure to the E407a solution causes no changes in the proton-donor ability of the media in the lipid membranes of leukocytes in the region where the probe locates. Conclusion: Exposure of white blood cell suspensions to the semirefined carrageenan solution does not affect the membrane hydration of the hydrophobic region of leukocyte phospholipid bilayer.
Heavy metal concentrations in soils and two vegetable crops (Corchorus olitorius and Solanum nigrum L.), their transfer from soil to vegetables and potential human health risks assessment at selected urban market gardens of Yaoundé, Cameroon

ABSTRACT Soil contamination by heavy metals has received considerable attention in recent years. In this study, heavy metal accumulation in two vegetable crops (Corchorus olitorius and Solanum nigrum L.) was studied. Assessment of soil properties and seven heavy metals (Zn, Cu, Cd, Ni, Pb, Cr and Mn) in soils and vegetables was done. Heavy metal transfer from soil to plant parts, translocation from roots to leaves and estimated potential health risks of heavy metal to humans via consumption of vegetable crops were studied. The ANOVA test showed that variations in the soil characteristics and heavy metal concentrations were statistically significant at level 0.05. Pearson correlation coefficients showed that the concentration of heavy metals has significant relationships with some soil properties like cation exchange capacity (CEC), organic carbon (OC) and soil texture. Bioconcentration factor (BCF) for both leaves and roots for Zn, Cu, Cd, Ni Cr and Mn were found to be greater than one, indicating the hyperaccumulation nature of vegetables. High translocation (TF) from root to leaves (TF>1) was recorded for Zn, Cu, Cd and Mn. The Health Risk Index (HRI) was found generally less than 1, suggesting that it is not risky for the Yaoundé city inhabitants to consume vegetable crops, except for Cd and Mn in Solanum nigrum L. Total Hazard Health Risk Index (THRI) expressed to know the overall harmful effects on health posed by several heavy metals taken together showed that the value for vegetables studied was higher than 1, suggesting the probability of adverse effects. The health risk is likely to occur for vegetable consumers.