Miracle-dz/UniFAR-FTUs huggingface dataset:
A morphologic and molecular reappraisal of myoepithelial tumors of soft tissue, bone, and viscera with EWSR1 and FUS gene rearrangements

Myoepithelial tumors (MET) represent a clinicopathologically heterogeneous group of tumors, ranging from benign to highly aggressive lesions. Although MET arising in soft tissue, bone, or viscera share morphologic and immunophenotypic overlap with their salivary gland and cutaneous counterparts, there is still controversy regarding their genetic relationship. Half of MET of soft tissue and bone harbor EWSR1 or FUS related fusions, while MET arising in the salivary gland and skin often show PLAG1 and HMGA2 gene rearrangements. Regardless of the site of origin, the gold standard in diagnosing a MET relies on demonstrating its “myoepithelial immunophenotype” of positivity for EMA/CK and S100 protein or GFAP. However, the morphologic spectrum of MET in soft tissue and bone is quite broad and the above immunoprofile is nonspecific, being shared by other pathogenetically unrelated neoplasms. Moreover, rare MET lack a diagnostic immunoprofile but shows instead the characteristic gene fusions. In this study, we analyzed a large cohort of 66 MET with EWSR1 and FUS gene rearrangements spanning various clinical presentations, to better define their morphologic spectrum and establish relevant pathologic‐molecular correlations. Genetic analysis was carried out by FISH for EWSR1/FUS rearrangements and potential partners, and/or by targeted RNA sequencing. Then, 82% showed EWSR1 rearrangement, while 18% had FUS abnormalities. EWSR1‐POU5F1 occurred with predilection in malignant MET in children and young adults and these tumors had nested epithelioid morphology and clear cytoplasm. In contrast, EWSR1/FUS‐PBX1/3 fusions were associated with benign and sclerotic spindle cell morphology. Tumors with EWSR1‐KLF17 showed chordoma‐like morphology. Our results demonstrate striking morphologic‐molecular correlations in MET of bone, soft tissue and viscera, which might have implications in their clinical behavior.
Components of Mindfulness Training: Impacts on Attention and Affect

The literature on mindfulness supports a distinction between two components of non-judgmental acceptance and directed attention. The present research analyzed whether there are distinct differences in attentional capabilities or affect between mindfulness inductions which differed in either including only directed attention or directed attention and non-judgmental acceptance. I hypothesized that the acceptance component of mindfulness would increase participants sustained attentional capabilities relative to a control condition; furthermore, I hypothesized that the non-judgmental acceptance component of mindfulness would lead to significant increases in positive affect and decreases in negative affect relative to control. Lastly, I hypothesized that an individual difference measure of need for cognitive closure would moderate this effect between non-judgmental acceptance and affect, such that individuals low in need for cognitive closure would see a significantly smaller benefits of the acceptance component relative to the directed attention condition. Results showed a significant increase in sustained attentional capabilities across time for the acceptance-based mindfulness condition, contrary to the literature. Furthermore, consistent with my hypothesis, NFC significantly moderated the relationship the negative affect felt by individuals in the acceptance condition such that participants low in NFC felt significantly more negative affect compared to the attention and control conditions. Therefore, the hypotheses were at least partially supported suggesting that individual differences and length of mindfulness training program should be taken into consideration.
The role of IL-17 in the pathogenesis of glomerulonephritis and ANCA-associated vasculitis

Induction of remission in ANCA-positive vasculitis: a rituximab based cyclophosphamide-sparing regime. Sally Hamour, Estela Nogueira, Ann-Marie Habib, Nicholas Mansfield, Tom Cairns, Megan Griffith, Jeremy Levy, Charles Pusey and Alan Salama American Society of Nephrology, Philadelphia 2008 (Poster presentation) Characterization of the IL-17 Pathway in ANCA Associated Vasculitis Estela Nogueira, Sally Hamour, Devika Tyagi, Maria Chavele, Karen Mosley, Charles Pusey and Alan Salama American Society of Nephrology, Philadelphia 2008 (Poster presentation) CycLowVas – a rituximab-based cyclophosphamide-sparing regime Sally Hamour, Nicholas Mansfield, Estela Nogueira, Anne-Marie Habib, Charles Pusey, Tom Cairns, Megan Griffith, Jeremy Levy, Gill Gaskin and Alan D. Salama ANCA Workshop, Sweden 2009 (Poster presentation) Sally Hamour PhD thesis 2012 7 Critical role of IL-17 in nephrotoxic nephritis Sally Hamour, Terence Cook, Yoichiro Iwakura, Charles Pusey and Alan Salama Renal Association, Liverpool 2009 (Poster presentation) IL-17 is elevated in patients with ANCA-associated vasculitis and persists during disease convalescence Estela Nogueira*, Sally Hamour*, Devika Tyagi, Konstantia-Maria Chavele, Karen Mosely, Charles Pusey and Alan Salama Renal Association, Liverpool 2009 (Poster presentation) *Denotes equal contribution IL-17 -/mice are protected from nephrotoxic nephritis and are resistant to disease induction by adoptive cell transfer Sally Hamour, Terence Cook, Yoichiro Iwakura, Charles Pusey and Alan Salama Renal association, Manchester 2010 (Poster presentation) IL-17 has a protective role in nephrotoxic nephritis Sally Hamour, Hsu-Han Wang, Terence Cook, Charles Pusey and Alan Salama Renal Association, Newcastle 2012 (Oral presentation) Sally Hamour PhD thesis 2012
Quantifying microbially mediated fitness differences reveals the tendency for plant-soil feedbacks to drive species exclusion among California annual plants

Soil microorganisms influence a variety of processes in plant communities. Many the-oretical and empirical studies have shown that dynamic feedbacks between plants and soil microbes can stabilize plant coexistence by generating negative frequency-dependent plant population dynamics. However, inferring the net effects of soil microbes on plant coexistence requires also quantifying the degree to which they provide one species an average fitness advantage, an effect that has received little empirical attention. We conducted a greenhouse study to quantify microbially mediated stabilization and fitness differences among fifteen pairs of annual plants that co-occur in southern California grasslands. We found that although soil microbes frequently generate negative frequency-dependent dynamics that stabilize plant interactions, they simultaneously mediate large average fitness differences between species. The net result is that if the plant species are otherwise competitively equivalent, the impact of plant-soil feedbacks is often to favor species exclusion over coexistence, a result that only becomes evident by quantifying the microbially mediated fitness difference. Our work highlights that comparing the stabilizing effects of plant-soil feedbacks to the fitness difference they generate is essential for understanding the influence of soil microbes on plant diversity.
CHARACTERIZATION AND ESTERIFICATION OF VARIOUS WASTE FRYING OILS AS FEEDSTOCKS FOR BIODIESEL PRODUCTION

The main objective of the study was to characterize and esterify ten waste frying oil (WFO) samples collected from fried food vendors and analyse their suitability as feedstock for biodiesel production. The parameters of the WFOs analyzed included; colour, odour, pH, specific gravity, kinematic viscosity (Oswald viscometer), moisture content (oven drying method), iodine value, saponification value, acid value and saponification value. Esterification was carried out to lower the free fatty acid (FFA) contents of the waste frying oils. Mean values for specific gravity varied from 0.892±0.022 to 0.905±0.075 g/cm 3 . The mean kinematic viscosity of the WFOs ranged from 43.120 ±1.530 to 97.530 ±6.360 mm 2 /s. The mean acid value obtained varied from 2.730 ±0.404 to 16.956 ±3.806 mg/g while the mean free fatty acid concentration in the WFO ranged from 1.95 ±0.17 to 12.09 ±2.11 mg/g. Results indicated that WFOs used for frying fish may not be good feedstocks for biodiesel production since they contained the highest levels of FFA. Both refined and unrefined oils were used for frying in the sampling area. The foodstuffs fried in the oils included Akara (bean cake), yam, potato, plantain and fish. Duration of use of the oils ranged from 5 days to 3 weeks. Only the free fatty acid contents of 4 samples were reduced below 0.5% by esterification while others ranged between 0.70% and 2.59%. Optimum conditions for the esterification were methanol:concentrated sulphuric acid ratio of 42:1; reaction temperature of 60 o C; reaction time of 30 min with 5 min application of heat
The complete mitochondrial genome of the extinct Pleistocene horse (Equus cf. lenensis) from Kotelny Island (New Siberian Islands, Russia) and its phylogenetic assessment

Abstract The complete mitochondrial genome from the Pleistocene stallion horse (Equus cf. lenensis) which complete skull was found in 1901 on Kotelny Island (New Siberian Archipelago, Sakha Republic, Russia) is published in this paper. The mitochondrial DNA (mtDNA) is 16,584 base pairs (bp) in length and contained 13 protein-coding genes, 2 rRNA genes, 22 tRNA genes. The overall base composition of the genome in descending order was 32.3% – A, 28.5% – C, 13.4% – G, 25.8% - T without a significant AT bias of 58.2%.
Energy Consumption - Economic Growth Nexus in Vietnam: An ARDL Approach with a Structural Break

Energy and energy consumption play an important role in strategies for socio-economic development of the country. In 1995, Vietnam officially entered the 500 kV North-South transmission power line exploits, with a full length of 1,487 km. The purpose of this study is to investigate the breakpoint and the transition effect of energy consumption to economic growth in Vietnam during the period of 1980-1994, and 1995-2016. The Autoregressive Distributed Lag (ARDL) approach and the Bounds test are used to test for the presence of cointegration, whereas the Toda and Yamamoto procedure Granger causality test is used for the direction of causality. The result of the Bounds test validates the existence of cointegration among the included variables. The empirical results provide evidence that energy consumption has a positive impact on the economic growth of Vietnam in the long run. The causality test shows that there is bi-directional causality between energy consumption and economic growth, supported feedback hypothesis. There is a breakpoint in 1995 and the contribution of energy consumption in economic growth in the period of 1995-2016 is lower than the stage 1980-1994. This study suggests Government authorities explore new sources of energy to achieve sustainable economic development in the long run.
Quantitative and qualitative land suitability assessment for rice cultivation, north of Iran

Evaluation of arable lands and agricultural potential to support current and future agricultural uses is one of the best agricultural policies for food security in developing countries. Hence, studies related to land suitability evaluation can lead to sustainable land use. The aims of this research were qualitative land suitability evaluation, land production potential prediction and quantitative land suitability evaluation on the basis of the FAO model for rice in Sangar region, northern Iran. Qualitative evaluation was carried out using the maximum limitation and parametric methods. Land production potential was determined by the agro-ecological zoning (AEZ) model. Land suitability classes according to maximum limitation, Storie and square root parametric methods are determined S3, S3-N1 and S2-S3, respectively. Rice radiation-thermal production potential was calculated as 7.65 t/ha; mean land production potentials, using Storie and square root formulas were predicted respectively, as 3.69 and 4.52 t/ha and mean actual yield was estimated as 2.81 t/ha. The results of this study showed that use of the square root formula is more appropriate than Storie formula as far as land production potential calculation is concerned. Soil limitations and weak management level have caused majority of land units to have moderate quantitative suitability (S2) for rice cultivation. Comparison between qualitative and quantitative suitability classes demonstrates that quantitative suitability classes are significantly increased due to crop adaptation with climate agents.
Genitourinary syndrome of menopause: Current and emerging therapies With more than 1 billion menopausal women likely to be affected by vulvovaginal atrophy worldwide by 2025, the need for effective remedies is acute. Here, 3 experts survey the options.

obgmanagement.com e1 Vol. 27 No. 8 | August 2015 | OBG Management Genitourinary syndrome of menopause (GSM) is the new terminology to describe symptoms occurring secondary to vulvovaginal atrophy. The recent change in terminology originated with a consensus panel comprising the board of directors of the International Society for the Study of Women’s Sexual Health (ISSWSH) and the board of trustees of the North American Menopause Society (NAMS). At a terminology consensus conference in May 2013, these groups determined that the term GSM is medically more accurate and all encompassing than vulvovaginal atrophy. It is also more publicly acceptable. The symptoms of GSM derive from the hypoestrogenic state most commonly associated with menopause and its effects on the genitourinary tract. Vaginal symptoms associated with GSM include vaginal or vulvar dryness, discharge, itching, and dyspareunia. Histologically, a loss of superficial epithelial cells in the genitourinary tract leads to thinning of the tissue. There is then a loss of vaginal rugae and elasticity, leading to narrowing and shortening of the vagina. In addition, the vaginal epithelium becomes much more fragile, which can lead to tears, bleeding, and fissures. There is also a loss of the subcutaneous fat of the labia majora, a change that can result in narrowing of the introitus, fusion of the labia majora, and shrinkage of the clitoral prepuce and urethra. The vaginal pH level becomes more alkaline, which may alter vaginal flora and increase the risk of urogenital infections— specifically, urinary tract infection (UTI). Vaginal secretions, largely transudate, from the vaginal vasculature also decrease over time. These changes lead to significant dyspareunia and impairment of sexual function. In this article, we survey the therapies available for GSM, focusing first on proven treatments such as local estrogen administration and use of ospemifene (Osphena), and then describing an emerging treatment involving the use of fractional CO 2 laser. Genitourinary syndrome of menopause: Current and emerging therapies
Searching for geological surface changes around the InSight landing site (Mars) from HiRISE satellite images.

(1) Institut de Physique du Globe de Paris, Sorbonne Paris Cité, Université Paris Diderot, CNRS F-75005 Paris, France, (2) Laboratoire de Météorologie Dynamique (LMD/IPSL), Sorbonne Université, CNRS, École Polytechnique, École Normale Supérieure, Paris, France, (3) Institut Supérieur de l’Aéronautique et de l’Espace (ISAE-SUPAERO), Université de Toulouse, F-31000 Toulouse, France, (4) Johns Hopkins University Applied Physics Laboratory, Laurel, Maryland 20723, USA, (5) Jet Propulsion Laboratory, California Institute of Technology, Pasadena, California, 91109-8099 USA, (6) Department of Earth and Planetary Sciences, Johns Hopkins University, Baltimore, MD, USA, (7) NASA Goddard Space Flight Center, Greenbelt, MD, USA, (8) Laboratoire de Planétologie et Géologie-UMR CNRS 6112, Université de Nantes, 2 rue de la houssinière, BP 92208, 44322 Nantes Cedex 3, France.
EFFECT OF BUSINESS STRATEGY AND PROFIT MANAGEMENT OF COMPANY PERFORMANCE 
(Case Study on Manufacturing Companies in the Consumer Goods Industry Sector on the Indonesia Stock Exchange 2013-2016)

The purpose of this study was to determine the effect of Business Strategy, Profit Management and Good Corporate Governance Mechanisms on Financial Performance This study used manufacturing companies in the consumer goods industry sector which were listed on the Indonesia Stock Exchange during 2013-2016. This research is a quantitative study that analyzes the Effect of Business Strategy, Profit Management and Good Corporate Governance Mechanisms on Financial Performance. This research uses multiple regression analysis methods. A good business strategy by suppressing earnings management activities through the mechanism of Good Corporate Governance is expected to improve company performance. The results of this study indicate that (1) the Business Strategy which is proxied by Low Cost and the mechanism of Good Corporate Governance which is proxied by the Independent Board of Commissioners has a significant positive effect on company performance, (2) the mechanism of Good Corporate Governance which is proxied by the Independent Board of Commissioners has a significant negative effect on company performance, (3) Profit Management and Good Corporate Governance mechanisms that are proxied by the Audit Committee have no effect on company performance.
Trends and spatial shifts in lightning fires and smoke concentrations in response to 21st century climate over the forests of the Western United States

Abstract. Almost US$ 3bn per year is appropriated for wildfire management on public land in the United States. Recent studies have suggested that ongoing climate change will lead to warmer and drier conditions in the Western United States with a consequent increase in the number and size of wildfires, yet large uncertainty exists in these projections. To assess the influence of future changes in climate and land cover on lightning-caused wildfires in National Forests and Parks of the Western United States and the consequences of these fires on air quality, we link a dynamic vegetation model that includes a process-based representation of fire (LPJ-LMfire) to a global chemical transport model (GEOS-Chem). Under a scenario of moderate future climate change (RCP4.5), increasing lightning-caused wildfire enhances the burden of smoke fine particulate matter (PM), with mass concentration increases of ~ 53 % by the late-21st century during the fire season. In a high-emissions scenario (RCP8.5), smoke PM concentrations double by 2100. RCP8.5 also shows large, northward shifts in dry matter burned, leading to enhanced lightning-caused fire activity especially over forests in the northern states.
Hydraulic Behavior in Cased and Open Hole Sections in Highly Deviated Wellbores

In this paper we present results from flow loop experiments with an oil-based drilling fluid with micronized barite as weight materials. The use of micronized barite allows using lower viscosity drilling fluid, providing non-laminar flow, which is advantageous for particle transport in near-horizontal sections. While transition to turbulence and turbulent flow of non-Newtonian fluids has been well studied both theoretically and experimentally, there are very few published results on the effect of wellbore wall properties on flow regime transition and turbulence. This is relevant because horizontal sections are often open-hole with less well-defined surfaces than a steel casing surface. We have conducted a series of flow experiments with and without cuttings size particles in a 10 m long annular test section using steel and concrete material to represent the wellbore wall of a cased and open hole section. In both cases the annulus was formed by a freely rotating steel pipe of 2” outer diameter inside a 4” diameter wellbore. Experiments were conducted at 48°, 60° and 90° wellbore inclination from vertical. The two materials result in different hydraulic behaviour without particles with stronger turbulence when using concrete wellbore wall material than when using steel casing. While there is negligible difference at low flow rates, at 0.8 m/s and below, there is an increasing difference as the flow rate increases and becomes transitional to turbulence. Hole cleaning is found to differ dependent on the wall material. However, the effect on hole cleaning is less clear than for the pressure loss.
Specific theories of crime? A longitudinal assessment of the competing effects of psychopathy and self-control

ABSTRACT The association between psychopathic personality traits (PPTs) and offending behavior has been studied extensively. Self-control also enjoys strong empirical support in its association with antisocial behavior. Further, research has shown that those with higher PPTs and those with lower self-control are more likely to be antisocial and are more likely to have protracted criminal careers. The current study used latent class growth analysis to compare how PPTs and self-control predict membership in longitudinal offending trajectories among an all-male sample of adjudicated delinquents (n = 726) from the Pathways to Desistance data. The results indicated that PPTs predicted membership across the persistent offending and desisting groups more often than self-control. Self-control, however, more often predicted membership within the persistent offending groups. Although both factors were among the most salient predictors of group membership, the results illustrated specific differences in how each factor can influence longitudinal patterns of offending.
CUNY Academic Works CUNY Academic Works Competition Between Veridical and Perceived Location for Competition Between Veridical and Perceived Location for Visuomotor Control Visuomotor Control How does access to this work benefit you? Let us know!

An influential proposal holds that our visual systems use different information for perception and action. Though numerous studies utilized visual illusions, in which veridical and perceptual properties of objects differ, the evidence was inconclusive and no consensus was reached. In response priming, some evidence suggests that only physical attributes of the prime stimuli control motor responses. Across two experiments, we examined the contributions of physical and consciously perceived location to response priming, using a well-known flash-lag illusion, in which a briefly flashed disk and the moving bars appearing at the same location are perceived as displaced. In all experiments, participants made speeded responses to the location of the target disk presented above or below the static bars. In the first experiment we kept the physical location of the prime disk constant; the disk and moving bars were presented at the same location. Responses to the target disk were consistently biased by the prime disk, demonstrating that rapid motor responses were primed by the illusory perception of the prime location. In the second experiment, we inverted the physical and perceived location of the prime. We estimated the size of illusion for each participant and then presented the prime disk either above or below the moving bars, so that perceived location was in alignment with the moving bars. Motor responses were moderated by the physical location of the disk, showing that visuomotor system used veridical prime location. Our experiments demonstrate that our visuomotor systems use both sources of information, veridical as well as consciously perceived location to guide behavior.