Miracle-dz/UniFAR-FTUs huggingface dataset:
A Bombieri–Vinogradov Theorem for Higher-Rank Groups

We establish a result of Bombieri–Vinogradov type for the Dirichlet coefficients at prime ideals of the standard $L$-function associated to a self-dual cuspidal automorphic representation $\pi $ of $\operatorname {GL}_n$ over a number field $F$ when $\pi$ is not a quadratic twist of itself. Our result does not rely on any unproven progress towards the generalized Ramanujan conjecture or the nonexistence of Landau–Siegel zeros. In particular, when $\pi $ is fixed and not equal to a quadratic twist of itself, we prove the first unconditional Siegel-type lower bound for the twisted $L$-values $|L(1,\pi \otimes \chi )|$ in the $\chi $-aspect, where $\chi $ is a primitive quadratic Hecke character over $F$. Our result improves the levels of distribution in other works that relied on these unproven hypotheses. As applications, when $n=2,3,4$, we prove a $\textrm {GL}_n$ analogue of the Titchmarsh divisor problem and a nontrivial bound for a certain $\textrm {GL}_n\times \textrm {GL}_2$ shifted convolution sum.
Subjective Assessment Experiments That Recruit Few Observers With Repetitions (FOWR)

Recent studies have shown that it is possible to characterize subject bias and variance in subjective assessment tests. Apparent differences among subjects can, for the most part, be explained by random factors. Building on that theory, we propose a subjective test design where four to six team members each rate the stimuli multiple times. The results are comparable to a high performing objective metric. This provides a quick and simple way to analyze new technologies and perform pre-tests for subjective assessment.
PointShuffleNet: Learning Non-Euclidean Features with Homotopy Equivalence and Mutual Information

Point cloud analysis is still a challenging task due to the disorder and sparsity of samplings of their geometric structures from 3D sensors. In this paper, we introduce the homotopy equivalence relation (HER) to make the neural networks learn the data distribution from a high-dimension manifold. A shuffle operation is adopted to construct HER for its randomness and zero-parameter. In addition, inspired by prior works, we propose a local mutual information regularizer (LMIR) to cut off the trivial path that leads to a classification error from HER. LMIR utilizes mutual information to measure the distance between the original feature and HER transformed feature and learns common features in a contrastive learning scheme. Thus, we combine HER and LMIR to give our model the ability to learn non-Euclidean features from a high-dimension manifold. This is named the non-Euclidean feature learner. Furthermore, we propose a new heuristics and efficiency point sampling algorithm named ClusterFPS to obtain approximate uniform sampling but at faster speed. ClusterFPS uses a cluster algorithm to divide a point cloud into several clusters and deploy the farthest point sampling algorithm on each cluster in parallel. By combining the above methods, we propose a novel point cloud analysis neural network called PointShuffleNet (PSN), which shows great promise in point cloud classification and segmentation. Extensive experiments show that our PSN achieves state-of-the-art results on ModelNet40, ShapeNet and S3DIS with high efficiency. Theoretically, we provide mathematical analysis toward understanding of what the data distribution HER has developed and why LMIR can drop the trivial path by maximizing mutual information implicitly.
Determinants of COVID-19 vaccine acceptance in a high infection-rate country: a cross-sectional study in Russia

Background: COVID-19 vaccine development is proceeding at an unprecedented pace. Once COVID-19 vaccines become widely available, it will be necessary to maximize public vaccine acceptance and coverage. Objective: This research aimed to analyze the predictors of COVID-19 vaccine acceptance in Russia. Methods: A cross-sectional online survey was conducted among Russian adults from September 26th to November 9th, 2020. Predictors of the intent to take up COVID-19 vaccination were explored using logistic regression. Results: Out of 876 participants, 365 (41.7%) would be willing to receive the vaccine if it became available. Acceptance increased for a vaccine with verified safety and effectiveness (63.2%). Intention to receive the COVID-19 vaccine was relatively higher among males (aOR=2.37, 95% CI 1.41-4.00), people with lower monthly income (aOR=2.94, 95%CI 1.32-6.57), and with positive trust in the healthcare system (aOR=2.73, 95% CI 1.76-4.24). The Russian people were more likely to accept the COVID-19 vaccine if they believed that the vaccine reduces the risk of virus infection (aOR=8.80, 95%CI 5.21-14.87) or relieves the complications of the disease (aOR=10.46, 95%CI 6.09-17.96). Other barriers such as being unconcerned about side-effects (aOR=1.65, 95%CI 1.03-2.65) and the effectiveness and safety of the vaccination (aOR=2.55, 95%CI 1.60-4.08), also affected acceptance. Conclusions: The study showed the usefulness of the health belief model constructs in understanding the COVID-19 vaccination acceptance rate in the Russian population. This rate was influenced by sociodemographic and health-related characteristics, and health beliefs. These findings might help guide future efforts for policymakers and stakeholders to improve vaccination rates by enhancing trust in the healthcare system.
Developing clinically practical transcranial direct current stimulation protocols to improve saccadic eye movement control

Recent research indicates that anodal transcranial direct current stimulation (tDCS) applied over the frontal eye field (FEF) can improve saccadic eye movement control in healthy young adults. The current research set out to determine whether similar results can be produced using a clinically practical protocol, whether tDCS applied over the dorsolateral prefrontal cortex (DLPFC) might also afford benefits, and whether benefits extend to older adults. Twenty young and 10 older adults completed two active (FEF and DLPFC) and one sham stimulation session. To aid clinical translation, the method of positioning the electrodes entailed simple measurements only. Saccadic performance following anodal tDCS applied over the FEF or DLPFC did not differ from the sham condition in either age group. Additionally, saccadic performance contralateral to the active electrodes showed no evidence of benefits over ipsilateral performance. These results call into question whether the protocol utilized can be applied effectively using only simple measurements to localize the relevant frontal subregion. Future efforts to develop a clinically practical tDCS protocol to improve saccadic eye movement control should include a sham control condition and consider adjusting the tDCS electrode montage and current strength to optimize the chances of conferring benefits in the population under study.
Thermo and pH dual responsive, polymer shell coated, magnetic mesoporous silica nanoparticles for controlled drug release

In this paper, a kind of core–shell composite microsphere was prepared based on poly(N-isopropylacrylamide-co-methacrylic acid) (P(NIPAM-co-MAA)) coated magnetic mesoporous silica nanoparticles (M-MSN) via precipitation polymerization. The composite microsphere presented a thermo/pH-coupling sensitivity and the volume phase transition could be precisely regulated by the molar ratio of MAA to NIPAM or the concentration of NaCl. At physiological conditions (37 °C, 0.15 M NaCl), the P(NIPAM-co-MAA) shell underwent a distinct transition from a swollen state in pH 7.4 to a collapsed state in pH 5.0, so that the polymer shell was active in moderating the diffusion of embedded drugs in-and-out of the pore channels of MSN. Doxorubicin hydrochloride (DOX) was applied as a model drug and the behaviors of drug storage/release were investigated. The drug loaded behavior was pH-dependent, and the composite microsphere had a drug embed efficiency of about 91.3% under alkaline conditions. The cumulative in vitro release of the DOX-loaded composite microsphere showed a low level of leakage below the volume phase transition temperature (VPTT) and was significantly enhanced above its VPTT, exhibiting an apparent thermo/pH-response controlled drug release. The cytotoxicity assay of a blank carrier to normal cells indicated that the composite microspheres were suitable as drug carriers, while the DOX-loaded composite microspheres had a similar cytotoxicity to HeLa cells compared with free DOX. Therefore, the thermo/pH-sensitive composite microsphere could, in principle, be used for in vivo cancer therapy with a low premature drug release during blood circulation whilst having a rapid release upon reaching tumor tissues.
The effectiveness of contrast-enhanced spectral mammography and magnetic resonance imaging in dense breasts

Purpose Breast cancer is the most common cause of death from neoplastic disease in women. Among all breast anatomy types, glandular type is the most problematic concerning evaluation. While digital mammography still remains the basic diagnostic tool, one must be aware of its limitations in dense breasts. Although magnetic resonance imaging (MRI) has greatly improved sensitivity, its specificity is low. Moreover, there are contraindications for MRI for some patients, so a substitute has been searched for. This study was performed to check if contrast-enhanced spectral mammography (CESM) can be a viable option for patients with dense breasts. Material and methods The study involved 121 patients with abnormalities detected on base-line diagnostic imaging (ultrasound or mammography). The patients had subsequent examinations, both CESM and MRI performed within a maximum 2-month time interval. The sensitivity and specificity of both methods in the whole group as well as in specific breast structure types were measured and compared. Results Contrast enhancement was visible in all 121 cases on MRI, while on CESM lack of enhancement was noted in 13 cases. All of those 13 lesions turned out to be benign. There were 40 (33%) benign and 81 (69%) malignant tumours. The analysed group included 53 (44%) glandular type breast patients, 39 (32%) mixed type, and 29 (23%) fatty type. Although MRI proved to be slightly more effective in dense breasts, both methods showed similar results in the whole study group. Conclusion CESM can be used with confidence in patients with glandular breast type when MRI is not available or there are reported contraindications to MRI.
Association between uric acid lowering and renal function progression: a longitudinal study

Background This study aimed to explore the association between uric acid lowering and renal function. Materials and Methods We conducted a population-based cohort study with 1,534 subjects for 4 years from 2012 to 2016. The population was divided into four groups according to the interquartile range of changes in serum uric acid with quartile 1 representing lower quarter. Renal function decline was defined as eGFR decreased more than 10% from baseline in 2016. Renal function improvement was defined as eGFR increased more than 10% from baseline in 2016. Cox regression analysis was used to calculate the hazard ratio (HR) and 95% confidence interval (CI). Results In the adjusted Cox regression models, compared to quartile 4, quartile 1 (HR = 0.64, 95% CI [0.49–0.85]), quartile 2 (HR = 0.65, 95% CI [0.50–0.84]) and quartile 3 (HR = 0.75, 95% CI [0.58–0.96]) have reduced risk of renal function decline. An increasing hazard ratio of renal function improvement was shown in quartile 1 (HR = 2.27, 95% CI [1.45–3.57]) and quartile 2 (HR = 1.78, 95% CI [1.17–2.69]) compared with quartile 4. Conclusions Uric acid lowering is associated with changes in renal function. The management of serum uric acid should receive attention in clinical practice and is supposed to be part of the treatment of chronic kidney disease.
Microsaccade rate as a measure of drug response

In 22 human subjects we measured microsaccade count across 60 brief fixation trials both pre- and post- administration of 300mg of caffeine. There was a statistically significant reduction in average microsaccade count post-caffeine administration, with a moderate effect size (Cohen’s d of 0.42). Microsaccade count was stable within individuals across time points (Pearson’s r of 0.89). Sensitivity analysis suggests that the pre/post caffeine effect size is robust to choice of parameters used to identify microsaccades. Bootstrap resampling suggests that both the pre/post-caffeine difference and the across-time stability within individuals could be reliably assessed with far fewer trials. The results support the use of microsaccade count as both a trait measure of individual differences and a state measure of caffeine response. We discuss the results in the context of the theory that the superior colliculus is central to the generation of microsaccades and hence that microsaccade rate may be a useful assay for at least some drug-induced changes at the level of the colliculus: a potentially useful tool in the development of therapies for disorders that may involve collicular dysfunction such as ADHD.
Global Trends of Green Pesticide Research from 1994 to 2019: A Bibliometric Analysis

The fast-growing world population places food production under enormous pressure to ensure food security. One of the most common methods to increase food production is the use of pesticides, but the continuous use thereof has numerous detrimental effects on the environment. The interest in biopesticides for a possible substitute has grown over the past two decades. To determine the research evolution of biopesticides (green pesticides), a bibliometric analysis from 1994 to 2019 was carried out. A total of 580 documents were found eligible in the Scopus database for this analysis. Parameters such as the number of articles, article citations, keywords, source impact, and countries of publication were used to analyse the documents and rank countries based on authors, productivity, article citations, and co-authorship. The analysis reveals production increased significantly from 2009 and has the most published documents in 2019 with a total of 74 articles. Asia's most populous countries, India and China, were ranked first and second, respectively, and the USA third in terms of the most productive countries in the field of plant biopesticides. Countries in Europe and Africa however have fewer publications than expected in this field, given the fact that they are high consumers of pesticides. India, China, and the USA have 4.08%, 2.94%, and 12.5% multiple country publications (MCPs), respectively, with the USA having a stronger collaboration. Finally, there is a clear indication in this study that India and China are taking the lead in substituting synthetic pesticides with the alternative natural plant biopesticide.
Do standard optometric measures predict binocular coordination during reading?

In reading, binocular eye movements are required for optimal visual processing and thus, in case of asthenopia or reading problems, standard orthoptic and optometric routines check individual binocular vision by a variety of tests. The present study therefore examines the predictive value of such standard measures of heterophoria, accommodative and vergence facility, AC/A-ratio, NPC and symptoms for binocular coordination parameters during read-ing. Binocular eye movements were recorded (EyeLink II) for 65 volunteers during a typical reading task and linear regression analyses related all parameters of binocular coordination to all above-mentioned optometric measures: while saccade disconjugacy was weakly pre-dicted by vergence facility (15% explained variance), vergence facility, AC/A and symp-toms scores predicted vergence drift (31%). Heterophoria, vergence facility and NPC ex-plained 31% of fixation disparity and first fixation duration showed minor relations to symp-toms (18%). In sum, we found only weak to moderate relationships, with expected, selective associations: dynamic parameter related to optometric tests addressing vergence dynamics, whereas the static parameter (fixation disparity) related mainly to heterophoria. Most sur-prisingly, symptoms were only loosely related to vergence drift and fixation duration, re-flecting associations to a dynamic aspect of binocular eye movements in reading and poten-tially non-specific, overall but slight reading deficiency. Thus, the efficiency of optometric tests to predict binocular coordination during reading was low – questioning a simple, straightforward extrapolation of such test results to an overlearned, complex task.
Morphological, morphometrical, and molecular characterization of Metarhabditis amsactae (Ali, Pervez, Andrabi, Sharma and Verma, 2011) Sudhaus, 2011 (Rhabditida, Rhabditidae) from India and proposal of Metarhabditis longicaudata as a junior synonym of M. amsactae

Abstract A new population of Metarhabditis amsactae from India is morphologically, morphometrically, and molecularly characterized. This material is characterized by having 0.65 to 1.14 mm length, lips rounded, and grouped in pairs, stoma with metastegostoma bearing setose denticles, pharynx with metacorpus slightly swollen and fusiform, nerve ring, and excretory pore located at isthmus level, female reproductive system didelphic-amphidelphic with vulva equatorial, female tail conical-elongate with acute tip, male tail conical with large and robust posterior filiform part, spicules free with hooked manubrium slightly bent ventrad, gubernaculum with narrow corpus, bursa open leptoderan with eight genital papillae and phasmids posterior to the GP8. Molecular studies based on 18S and 28S rDNA genes are provided for the first time for the species. In addition, integrated morphological, morphometrical, and molecular characters are compared with other previous records of the species. According to our analysis, Metarhabditis longicaudata and other material described as different species are proposed as new junior synonyms of M. amsactae.
Assessment of the efficiency of a pre- versus post-acquisition metal artifact reduction algorithm in the presence of 3 different dental implant materials using multiple CBCT settings: An in vitro study

Purpose The aim of this study was to assess artifacts generated in cone-beam computed tomography (CBCT) of 3 types of dental implants using 3 metal artifact reduction (MAR) algorithm conditions (pre-acquisition MAR, postacquisition MAR, and no MAR), and 2 peak kilovoltage (kVp) settings. Materials and Methods Titanium-zirconium, titanium, and zirconium alloy implants were placed in a dry mandible. CBCT images were acquired using 84 and 90 kVp and at normal resolution for all 3 MAR conditions. The images were analyzed using ImageJ software (National Institutes of Health, Bethesda, MD) to calculate the intensity of artifacts for each combination of material and settings. A 3-factor analysis of variance model with up to 3-way interactions was used to determine whether there was a statistically significant difference in the mean intensity of artifacts associated with each factor. Results The analysis of all 3 MAR conditions showed that using no MAR resulted in substantially more severe artifacts than either of the 2 MAR algorithms for the 3 implant materials; however, there were no significant differences between pre- and post-acquisition MAR. The 90 kVp setting generated less intense artifacts on average than the 84 kVp setting. The titanium-zirconium alloy generated significantly less intense artifacts than zirconium. Titanium generated artifacts at an intermediate level relative to the other 2 implant materials, but was not statistically significantly different from either. Conclusion This in vitro study suggests that artifacts can be minimized by using a titanium-zirconium alloy at the 90 kVp setting, with either MAR setting.
Effects of aligning prisms on the objective and subjective fixation disparity in far distance

Fixation disparity (FD) refers to a suboptimal condition of binocular vision. The oculomotor aspect of FD refers to a misadjustment in the vergence angle between the two visual axes that is measured in research with eye trackers (objective fixation disparity, oFD). The sensory aspect is psychophysically tested using dichoptic nonius lines (subjective fixation disparity, sFD). Some optometrists use nonius tests to determine the prisms for constant wear aiming to align the eyes. However, they do not (yet) use eye trackers. We investigate the effect of aligning prisms on oFD and sFD for 60 sec exposure duration of prisms determined with the clinically established Cross test in far distance vision. Without prisms, both types of FD were correlated with the aligning prism, while with prisms the FD was close to zero (these analyses included all base-in and base-out cases). The effect of base-in prisms on oFD was proportional to the amount of the aligning prism for the present 60 sec exposure, similar as for the 2- 5 sec exposure in Schmid et al. (2018). Thus, within 1 minute of prism exposure, no substantial vergence adaptation seems to occur in the present test conditions. Further studies may investigate intra-individual responses to different exposure times of aligning prisms in both prism directions.
Characterization of the leafhopper mitogenome of Mileewa alara (Hemiptera: Cicadellidae: Mileewinae) and its phylogenetic analysis

Abstract The mitogenome data of leafhopper species Mileewa alara was assembled and annotated in this study. The results shows that length of M. alara is 16020 bp, consist of 13 protein-coding genes (PCGs), 22 tRNA genes, 2 rRNA genes, and one control region. The A + T content in the mitogenome was 77.9%. Phylogenetic analysis based on 13 PCGs of four Mileewa species and other 29 Cicadellidae species, each subfamily species well separated. And M. alara clustered with M. ponta. This study also raised mitogenome of Mileewa number in GenBank to four.
Molecular subgroup of periodontitis revealed by integrated analysis of the microbiome and metabolome in a cross-sectional observational study

ABSTRACT Background: Periodontitis (PT) is a multifactorial, chronic inflammatory disease that can have heterogeneous clinical presentations. The oral microbiome and its metabolites have been implicated as the causes and regulators of PT pathogenesis. In this study, we assessed the oral microbiome and its metabolome in PT patients to clarify the interactions between the microbiome and its metabolites.Methods: A total of 112 subjects were recruited. Buccal and supragingival samples were collected for microbiome analysis. Saliva samples were collected for metabolomic analyses. Microbiome and metabolome data were analyzed and further integrated for combined analysis using various bioinformatics approaches.Results: Oral metabolomic analysis identified 28 metabolites distinguishing the healthy (H) and PT groups. PT group were further clustered into two subgroups (PT_G1 and PT_G2) depending on metabolite profiles. Oral microbiome analysis revealed discriminatory bacterial species in the H, PT_G1, and PT_G2 microbiota. Interestingly, PT_G2 had significantly higher concentration of short chain fatty acids and higher abundance of pathogenic bacteria. Integrated analysis of the microbiome and metabolome showed close association.Conclusion: Our results provide evidence of a close interplay between the oral microbiome and metabolome. Multi-omics approach including microbiome and microbe-associated metabolites may serve as diagnostic biomarkers and enhance treatment prediction in periodontal disease.