Miracle-dz/UniFAR-FTUs huggingface dataset:
Different extrapolation of moving object locations in perception, smooth pursuit and saccades

The ability to accurately perceive and track moving objects is crucial for many everyday activities. In this study, we use a “double-drift stimulus” Lisi and Cavanagh (2015); Shapiro et al. (2010); Tse and Hsieh (2006) to explore the processing of visual motion signals that underlie perception, pursuit, and saccade responses to a moving object. Participants were presented with peripheral moving apertures filled with noise that either drifted orthogonally to the aperture’s direction or had no net motion. Participants were asked to saccade to and track these targets with their gaze as soon as they appeared, and then to report their direction. In the trials with internal motion, the target disappeared at saccade onset so that the first 100 ms of the post-saccadic pursuit response was driven uniquely by peripheral information gathered before saccade onset. This provided independent measures of perceptual, pursuit, and saccadic responses to the double-drift stimulus on a trial-by-trial basis. Our analysis revealed systematic differences between saccadic responses on one hand and perceptual and pursuit responses on the other. These differences are unlikely to be caused by differences in the processing of motion signals because saccade and pursuit appear to use a common motion processing mechanism (e.g., Erkelens, 2006; Fleuriet and Goffart, 2012). We conclude that our results are instead due to a difference in how the processing mechanisms underlying perception, pursuit, and saccades combine motor signals with target position. These findings advance our understanding of the mechanisms underlying dissociation in visual processing between perception and eye movements.
Inhibition mechanism and antiviral activity of an α-ketoamide based SARS-CoV-2 main protease inhibitor

SARS-CoV-2 has demonstrated extraordinary ability to evade antibody immunity by antigenic drift. Small molecule drugs may provide effective therapy while being part of a solution to circumvent SARS-CoV-2 immune escape. In this study we report an α-ketoamide based peptidomimetic inhibitor of SARS-CoV-2 main protease (Mpro), RAY1216. Enzyme inhibition kinetic analysis established that RAY1216 is a slow-tight inhibitor with a Ki of 8.6 nM; RAY1216 has a drug-target residence time of 104 min compared to 9 min of PF-07321332 (nirmatrelvir), the antiviral component in Paxlovid, suggesting that RAY1216 is approximately 12 times slower to dissociate from the protease-inhibitor complex compared to PF-07321332. Crystal structure of SARS-CoV-2 Mpro:RAY1216 complex demonstrates that RAY1216 is covalently attached to the catalytic Cys145 through the α-ketoamide warhead; more extensive interactions are identified between bound RAY1216 and Mpro active site compared to PF-07321332, consistent with a more stable acyl-enzyme inhibition complex for RAY1216. In cell culture and human ACE2 transgenic mouse models, RAY1216 demonstrates comparable antiviral activities towards different SARS-CoV-2 virus variants compared to PF-07321332. Improvement in pharmacokinetics has been observed for RAY1216 over PF-07321332 in various animal models, which may allow RAY1216 to be used without ritonavir. RAY1216 is currently undergoing phase III clinical trials (https://clinicaltrials.gov/ct2/show/NCT05620160) to test real-world therapeutic efficacy against COVID-19.
Inferring functional organization of posterior parietal cortex circuitry based on information flow

Many studies infer the role of neurons by asking what information can be decoded from their activity or by observing the consequences of perturbing their activity. An alternative approach is to consider information flow between neurons. We applied this approach to the Parietal Reach Region (PRR) and the Lateral Intraparietal area (LIP) in posterior parietal cortex. Two complementary methods show that, across a range of reaching tasks, information flows primarily from PRR to LIP but not vice versa. This suggests that PRR determines the spatial goals of coordinated eye and arm movements and instructs LIP of those goals. Based on these findings, we conclude that PRR and LIP operate in a parallel rather than hierarchical manner to plan arm and eye movements, respectively. Similar methodology can be applied to other areas to infer their relative relationships.
Evolution of massive AGB stars - III. the thermally pulsing super-AGB phase

Aims. We present the first simulations of the full evolution of super-AGB stars through the entire thermally pulsing AGB phase. We analyse their structural and evolutionary properties and determine the first SAGB yields. Methods. Stellar models of various initial masses and metallicities were computed using standard physical assumptions which prevents the third dredge-up from occurring. A postprocessing nucleosynthesis code was used to compute the SAGB yields, to quantify the effect of the third dredge-up (3DUP), and to assess the uncertainties associated with the treatment of convection. Results. Owing to their massive oxygen-neon core, SAGB stars suffer weak thermal pulses, have very short interpulse periods and develop very high temperatures at the base of their convective envelope (up to 140 × 10 8 K), leading to very efficient hot bottom burning. SAGB stars are consequently heavy manufacturers of 4 He, 13 C, and 14 N. They are also able to inject significant amounts of 7 Li, 17 O, 25 Mg, and 26,27 Al in the interstellar medium. The 3DUP mainly affects the CNO yields, especially in the lower metallicity models. Our post-processing simulations also indicate that changes in the temperature at the base of the convective envelope, which would result from a change in the efficiency of convective energy transport, have a dramatic impact on the yields and represent another major source of uncertainty.
ON THE VALIDITY OF THE FORMAL EDGEWORTH EXPANSION

EZ1. This asymptotic expansion is shown to be identical with a formal Edgeworth expansion of the distribution function of W. This settles a conjecture of Wallace (1958). The class of statistics considered includes all appropriately smooth functions of sample moments. An application yields asymptotic expansions of distributions of maximum likelihood estimators and, more generally, minimum contrast estimators of vector parameters under readily verifiable distributional assumptions.
Study of Gap Physics of Airfoils with Unsteady Flaps

Active trailing-edge flaps are a method of aerodynamic control under extensive research to reduce the detrimental effects of dynamic stall. Physical phenomena are poorly understood in the context of active flaps including vorticity and acoustics, separation, and transition. In addition, discrete trailing-edge flaps create a cavity-like flow within the airfoil-flap gap that can complicate these phenomena. This work has explored the physical response of a static airfoil with a discrete noncontoured oscillating flap over a range of freestream parameters. The effects of attached and separated flows, flap oscillation scheduling, airfoil-flap gap size, and freestream speed have all been investigated. Time-accurate predictions were performed using a hybrid Reynolds-averaged Navier–Stokes/large eddy simulation turbulence model. Trailing-edge stall suppression and an increase between aerodynamic response and deflection input were observed as the flap oscillation frequency increased. The lag between response and in.
Laminar separating flow over backsteps and cavities. I - Backsteps

Although significant data on flow over backward facing steps and cavities in turbulent flow are available, the corresponding data for the laminar flow are rather scant. The present work reports the results of an experimental investigation carried out at a wind speed of 1.8 m/s over three backward facing steps 0.625,1.25, and 2.5 cm high; the separating boundary layer in all cases was laminar and was 1.4 cm thick. Data obtained through smoke flow visualization and static pressure and hot wire measurements are divided into two categories: category A—variation of the reattachment length with Reynolds number in the range 100-12,500, and category B—general pattern of flow between the point of separation and that of reattachment. The data in the latter category include 1) pressure profiles on the step surfaces, 2) typical development of streamwise mean velocity profile and intensity of fluctuations, 3) variation of momentum thickness of the laminar separating shear layer downstream of the steps.
Operator Reliance on Automated Support for Target Recognition

In machine-aided target recognition, human operators work with an automatic target recognition (ATR) system to locate targets in cluttered and degraded imagery. The operator must integrate his or her own visual judgment concerning whether a target is present in the image with the ATR's judgment, which is typically expressed numerically. We conducted a series of experiments in which subjects attempted to locate target shapes among non-targets based only on visual images and based on both visual images and supplementary numeric information such as an ATR might provide. Image quality was controlled as an independent variable through the use of distortion rates that randomly altered pixel values to degrade the image. We found that subjects maintained a constant false alarm rate as image distortion increased, at the expense of a lower hit rate. This result was found consistently in experiments where the subjects' task was to distinguish single targets from a blank background, to distinguish single targets from single non-targets, and to locate multiple targets in a multiple-object display. We also found a bias toward over reliance on image versus numeric information. As image distortion increased, subjects failed to make optimal use of supplementary numeric information and showed an unnecessary decrease in performance. The results suggest that operators may experience difficulty in working with an ATR that has a high false alarm rate, even if the ATR's hit rate is also high, and that numeric expressions of ATR judgment may be undervalued by operators in locating targets.
EXOSAT observations of V471 Tauri - a 9. 25 minute white dwarf pulsation and orbital phase dependent X-ray dips

New results obtained from a 28 hr continuous observation of V471 Tauri with the EXOSAT satellite are reported. The detection of soft X-ray fluxes from both the white dwarf and the K dwarf, the discovery of a 9.25 minute pulsation from the white dwarf, and the discovery of orbital phase-related soft X-ray dips are discussed. The dips may be correlated with the triangular Lagrangian points of the binary orbit. The X-ray flux from the white dwarf is consistent with thermal models for a white dwarf photosphere with T(eff) of about 35,000 K, log g = 8.0-8.5, and log N(H) = 18.65 + or - 0.2. 25 references.
Local anisotropy in heated and cooled turbulent boundary layers

Turbulent temperature as well as streamwise and vertical velocity components have been measured in relatively high Reynolds number (Rλ∼1100) heated and cooled boundary layers of the Air–Sea Interaction Simulation Tunnel at the Institut de Mecanique Statistique de la Turbulence. Spectra and probability distributions are compared with various consequences of Kolmogoroff’s assumption of local isotropy. The spectral functions present a first approximation agreement with the assumption. Yet, evidence of local anisotropy is shown by the values of the skewness of ∂T/∂x1 which are very different from zero, either positive or negative. Possible errors due to cold wire velocity sensitivity are examined. An apparent connection between small scale and large scale anisotropy is discussed.
Influence of the Choice of Core-Envelope Transition Point on the Binary Merger of Two Main-sequence Components

We have studied the influence of different choices of core-envelope transition point on the final merger of contact binaries with two main-sequence components. A binary of 1.00 + 0.90 M-circle dot with an initial orbital period of 0.35 d is examined. The mass fraction of the primary mixed with the matter of the secondary, q(mix), determined by the chosen core-envelope transition point, ranges from 0.04 to 1.00 in our analysis. If as qmix 0.71, since no hydrogen-rich matter of the secondary is mixed into the core of the mergers; for q(mix) > 0.71, the larger qmix is, the greater the mixing, hence the longer the blue straggler lifetime, tBS, and also the greater the luminosity. For qmix = 1.00, tBS similar to 8.5 x 10(8) yr. Estimation by del(r) - del(a) = 0.0 shows that the point at which tBS begins to increase is about q(mix) = 0.68. In comparison with the homogeneously mixed models, the merger with a helium profile similar to that of the primary is less luminous and has a shorter tBS.
The application of artificial neural networks in the detection of mandibular fractures using panoramic radiography

Background: Panoramic radiography is a standard diagnostic imaging method for dentists. However, it is challenging to detect mandibular trauma and fractures in panoramic radiographs due to the superimposed facial skeleton structures. The objective of this study was to develop a deep learning algorithm that is capable of detecting mandibular fractures and trauma automatically and compare its performance with general dentists. Materials and Methods: This is a retrospective diagnostic test accuracy study. This study used a two-stage deep learning framework. To train the model, 190 panoramic images were collected from four different sources. The mandible was first segmented using a U-net model. Then, to detect fractures, a model named Faster region-based convolutional neural network was applied. In the end, a comparison was made between the accuracy, specificity, and sensitivity of artificial intelligence and general dentists in trauma diagnosis. Results: The mAP50 and mAP75 for object detection were 98.66% and 57.90%, respectively. The classification accuracy of the model was 91.67%. The sensitivity and specificity of the model were 100% and 83.33%, respectively. On the other hand, human-level diagnostic accuracy, sensitivity, and specificity were 87.22 ± 8.91, 82.22 ± 16.39, and 92.22 ± 6.33, respectively. Conclusion: Our framework can provide a level of performance better than general dentists when it comes to diagnosing trauma or fractures.
A comparative evaluation of light cure calcium silicate and resin-modified glass ionomer as indirect pulp capping agent in primary molars: A randomized clinical trial

Background: Minimally invasive techniques should be employed to maintain pulp vitality without affecting physiological tooth resorption for pediatric patients. This study aims to evaluate clinical and radiographic success of light cure calcium silicate and resin-modified glass ionomer (RMGI) as indirect pulp-capping agent in primary molars in children between 5 and 9 years. Materials and Methods: In this randomized clinical trial study, 40 primary molars with the International Caries Detection and Assessment System criteria 4–6 score were divided randomly into two groups after computerized randomization method. After caries excavation by minimally invasive dentistry principle, affected dentin was lined by either light cure calcium silicate (Group I) or RMGI (Group II) liner followed by composite restoration. Clinical success was determined with the absence of symptoms and bitewing radiographs were taken at baseline, 3, and 6 months' interval to measure increase in dentin increment using ImageJ software. Statistical analysis for intergroup comparison was done using Paired t-test, and Independent t-test was used for intragroup comparison. The level of statistical significance was set at P < 0.05. Results: Change in dentin increment seen from baseline to 6 months in Group I was 0.19 mm and in Group II was 0.20 mm (P = 0.924). Intragroup increment was statistically significant during all follow-up intervals for both the groups (Group I – P ≤ 0.001, Group II – P = 0.009). For baseline remaining dentin thickness >1.5 mm, statistically significant increase was observed in the dentin increment at 3 months' interval between both the groups. Conclusion: Both TheraCal LC and Vitrebond show acceptable clinical and radiographic results when used in primary molars as indirect pulp treatment agents. Both the liners are equivalent to each other in terms of feasibility and cost-effectiveness but TheraCal LC can be preferred due to better handling and avoiding the manipulation step thereby reducing treatment time.
Evaluation of the effect of green tea extract on postoperative pain management following surgical removal of impacted mandibular third molar

Background: Pain following surgical removal of impacted molars has remained a principal concern among practitioners. Since green tea has anti-inflammatory and anti-bacterial properties, the current study aimed to evaluate the efficacy of green tea extract local application in controlling postoperative pain following surgical extraction of the impacted mandibular third molar teeth. Materials and Methods: In a double-blinded randomized controlled trial study with a split-mouth design, 32 patients underwent bilateral removal of impacted third molars in a 2-month time interval; afterward, the sterile gauzes impregnated with green tea extract and saline were applied randomly to the surgical sites. Postoperative pain was evaluated 6, 12, 24, and 48 h after surgery using a questionnaire based on the Visual Analog Scale (VAS) and the number of analgesics used after surgery. Data were subjected to exact and Chi-square tests with the significance level set at 0.05. Results: There was a decrease in the mean scores of the VAS and the mean number of analgesic consumptions in the first 2 days after surgery. Chi-square test results showed a significant reduction in the VAS scores after applying the green tea extract only 6 and 12 h after surgery (P < 0.05). Moreover, the number of analgesic consumptions was significantly lower in the green tea group compared to the control group. Conclusion: Green tea extract may be an appropriate and safe choice for postoperative pain control after surgical extraction of the impacted mandibular third molar teeth.
Attitude of dental students toward evidence-based dentistry in Iran: A systematic review

Background: Dentistry practice has become more complex and challenging in the recent years. The clinical decision-making process has experienced many problems due to changing socioeconomic patterns, knowledgeable patients, rapid technological advances, and information explosion. The present study reviewed the status of the attitude toward evidence-based dentistry (EBD) among dental students of Iran Universities. The effect of the educational intervention was also assessed. Materials and Methods: This systematic review was conducted according to the Preferred Reporting Items for Systematic review and Meta-Analysis checklist. Search strategy was developed by Medical Subject Headings terms and keywords surfing electronic available databases including Medline/PubMed and Google Scholar and local databases such as Scientific Information Database (SID) and Magiran. Two reviewers read the abstracts of all eligible papers and excluded the duplicates. They extracted the information of the full-text of the studies included in the review and assessed the quality by Joanna Briggs Institute critical appraisal checklist. Results: Ten studies including 8 cross-sectional and 2 interventional studies met the criteria. The assessment of the attitude of 937 dental students from a different region of the country toward EBD showed moderate to acceptable status using 3 different tools. In regard to educational interventions, 2 studies were successful to improve their attitude. Conclusion: Although the researchers presented good scores on the attitude questionnaires, the quality of the study tools, the eligible criteria for recruiting the participants and the method of evaluating the construct of attitude should be investigated in future studies.
The effect of ostrich acellular dermal matrix on keratinized gingival width

Background: Xenogeneic grafts have gained attention due to advantages in compare of autografts. This study aimed to compare Xeno (ostrich) Acellular Dermal Matrix (XADM) with the free gingival graft (FGG) to increase the width of Keratinized gingiva (KGW) in dogs. Materials and Methods: This split mouth animal study was performed on 10 mixed breed dogs. The upper second premolar sites were randomly selected for grafting by XADM (test) or FGG (control). Measurements of KGW were recorded before surgery, 1, 3, and 6 months after surgery. Biopsies from grafted sites for histologic and histomorphometric evaluations were harvested 6 months after surgery. Data were analyzed by repeated measured, paired samples t-test, and Wilcoxon Signed rank test. P < 0.05 was considered statistically significant. Results: KGW increased in the two study groups after surgery with no significant statistical difference between them at any time intervals (P > 0.05). The graft shrinkage was 23% and 21% for the test and control groups, respectively, without statistically significant difference (P > 0.05). Histomorphometric evaluation showed no significant difference between the two study groups. Foreign body reaction was not seen in any of the study groups. Conclusion: Increased KWG was similar between the two study groups. With regard to FGG limitations, XADM may be assumed as a suitable alternative for FGG. It should be noted that this research was an animal study and clinical trials on human should be performed to approve the efficacy and safety of this material.
The Prevalence and Determinants of Vitamin D Status among Older Adults: Data from a Longitudinal Aging Study

Background: Aging is identified as a risk factor for vitamin D deficiency (VDD) therefore this investigation was designed to determine the prevalence of VDD and its determinants in a sample of older adults. Methods: The data of this study were obtained from the baseline wave of the Longitudinal Aging Study (LAS). Demographic, past medical history, medication history, and smoking behavior were collected using an interview approach. The physical activity and nutritional status of the participants were assessed using a standard questionnaire. Anthropometric indices were measured according to a standard protocol then body mass index (BMI) was calculated. Serum vitamin D and calcium levels were measured by autoanalyzers. Univariate and multiple logistic regression models were applied to detect the associated factors with VDD. Results: Mean age of the participants was 71.82 (SD = 7.63) years. A total of 1319 people participated in our study, and 51.16% (n = 688) were female. A total of 8.42% (n = 111) of the participants had VDD and 17.06% of them (n = 225) had insufficient vitamin D levels. In the multivariable logistic regression model, the age group of 70–79 years in comparison with the age group of 60–69 years had a 43% less chance of VDD. Furthermore, being overweight (OR = 0.36, P = 0.01) and obese (OR = 0.35, P = 0.02), and taking vitamin D supplements (OR = 0.31, P = 0.04) were significantly associated with VDD. Conclusions: Our results showed that 25% of older adults had vitamin D deficiency or insufficiency. In addition, some modifiable lifestyle factors were associated with VDD. Given that, old age is considered a risk factor for VDD. Therefore, detection and improvement of VDD may be a preventive measure in at-risk subjects.