Miracle-dz/UniFAR-FTUs huggingface dataset:
DDDT_A_360346 1605..1620

Background: Epithelial–mesenchymal transition (EMT) plays an important role in interstitial matrix deposition and renal fibrosis in diabetic kidney disease (DKD). It has been verified that Astragaloside IV (AS-IV) is beneficial for ameliorating DKD. However, the underlying mechanisms of AS-IV on regulating EMT in DKD are yet to be established. Accumulated evidence has suggested that C-X3-C motif ligand 1 (CX3CL1) plays a significant role in the progression of EMT. Purpose: We aimed to investigate whether AS-IV could alleviate EMT by regulating CX3CL1 in DKD and reveal its underlying mechanisms. Methods: For the in vivo study, mice were divided into the following five groups (n=10): db/m+vehicle, db/db+vehicle, db/db+AS-IV-L (10mg/kg/d), db/db+AS-IV-M (20mg/kg/d), db/db+AS-IV-H (40mg/kg/d). After 12 weeks of treatment, the renal injuries were assessed based on the related parameters of urine, blood and histopathological examination. Immunohistochemistry and Western blotting were used to detect relative proteins levels. Then in HK-2 cells, the molecular mechanism of AS-IV attenuating the EMT in mice with DKD through the CX3CL1-RAF/MEK/ERK pathway was studied. Results: In the present study, we found that AS-IV reduced urinary protein levels and improved renal pathological damage in DKD mice. Moreover, AS-IV ameliorated the renal tubular EMT induced by hyperglycemia or high glucose (HG), and decreased the expression of CX3CL1 and inhibited the activation of the RAF/MEK/ERK pathway in vivo and in vitro. In HK-2 cells, downregulation of CX3CL1 suppressed the stimulation of the RAF/MEK/ERK pathway and EMT induced by HG. However, CX3CL1 overexpression eliminated the benefits of AS-IV on the RAF/MEK/ERK pathway and EMT. Conclusion: In summary, we indicated that AS-IV alleviates renal tubular EMT through the CX3CL1-RAF/MEK/ERK signaling pathway, indicating that CX3CL1 could be a potential therapeutic target of AS-IV in DKD.
Renewing ​ ​ Research ​ ​ on ​ ​ Problemistic ​

​ on ​ ​ Problemistic ​ ​ Search ABSTRACT Problemistic search theory, with its roots in the Carnegie School tradition, describes a behaviorally plausible process by which firms learn from performance feedback. A firm’s recognition of performance below aspirations leads to search for a solution to the problem, resulting in change intended to restore performance to the aspired level. The concept of problemistic search has diffused broadly in the management literature — it is a central theoretical concept in a broad variety of organizational theories, and an important explanation of a wide variety of organizational behaviors and outcomes. We review the literature and argue that the development of the theory has not kept pace with the breadth of the unfolding literature. We identify six critical issues with extant research that can be traced back to a continued (over) reliance on the initial conceptualization of problemistic search. To address these issues and to revitalize research, we propose a research agenda premised on a more central role for cognition in the ​ ​ theory ​ ​ and
Effects of Korean fathers’ participation in parenting, parental role satisfaction, and parenting stress on their child’s playfulness

ABSTRACT This study aimed to examine the effects of fathers’ participation in parenting, parental role satisfaction and parenting stress on their child’s playfulness. The sample of the study consisted of 300 fathers of children aged eight years and below (children studying in second or lower grades), living in Korea. The subjects were surveyed between April and May, 2021. The results of the study were as follows: fathers’ participation in parenting and parental role satisfaction were positively related, while fathers’ participation in parenting and parenting stress were negatively related. Child’s playfulness was positively related to fathers’ participation in parenting and parental role satisfaction, and negatively related to parenting stress. It was confirmed that fathers’ participation in parenting, parental role satisfaction, and parenting stress are variables that affect child’s playfulness. Fathers’ participation in parenting had the greatest impact on child’s playfulness, followed by parental role satisfaction and parenting stress.
0491 Sleep among Adolescents in Juvenile Detention

Adolescents involved in the juvenile justice system demonstrate high rates of psychiatric disorders, suicidality, and trauma, all of which is associated with poor sleep. Poor sleep is common among adolescents and is associated with numerous adverse outcomes like inattention, school absenteeism, emotion dysregulation, and substance use, outcomes that are related to juvenile justice system involvement. Yet very little is known about the sleep of adolescents involved in the juvenile justice system. We conducted a medical chart review and survey of detained adolescents to describe the sleep patterns and problems among these youth. We reviewed a random sample (26%) of the medical charts of youth detained in a juvenile detention center (n=31) over four days in Summer 2021. We reviewed all medical encounters in the month prior to the date of chart review. Additionally, 13 youth completed the Patient Reported Outcome Measurement Information System Pediatric Sleep Disturbance Short Form (PROMIS-SD). Twelve of them reported their sleep patterns while in detention. Sleep was mentioned in 23% of all medical encounters, 62% of which indicated poor sleep. Sleep treatment was documented in 24% of notes, all consisting of pharmacotherapy. A sleep diagnosis was documented on 37% of billing sheets of all youth seen by a medical provider in the detention center in July 2021. On average, participants reported lights out around 9pm (SD=35min), sleep onset latency of 74mins (SD=75mins), wake time after sleep onset of ~20 minutes (SD=16mins), and wake-up time of 7:50am (SD=67min). Youth reported average sleep duration of more than 9 hours while detained (SD=103mins). Average PROMIS-SD score was 66.2 (range 51.5-79.1) Though most youth obtain the recommended amount of sleep while detained, sleep disturbance is highly common among this population and average sleep disturbance is more than one standard deviation above the average. These data may inform the type of sleep interventions that are most relevant to detained youth. Future work should focus on further examining the sleep of adolescents in the juvenile justice system and identifying feasible, acceptable, and useful strategies for implementing evidence-based sleep interventions in this setting. Dr. Levenson’s effort was supported by K23HD087433
Detection of Genomic Regions Controlling the Antioxidant Enzymes, Phenolic Content, and Antioxidant Activities in Rice Grain through Association Mapping

Because it is rich in antioxidant compounds, the staple food of rice provides many health benefits. Four antioxidant traits in rice grain, viz., catalase, CUPRAC, DPPH, FRAP and peroxidase, were mapped in a representative panel population containing 117 germplasm lines using 131 SSR markers through association mapping. Donor lines rich in multiple antioxidant properties were identified from the mapping population. The population was classified into three genetic groups and each group showed reasonable correspondence with the antioxidant traits. The presence of linkage disequilibrium in the population was confirmed from the estimated Fst values. A strong positive correlation of DPPH was established with TPC, FRAP and CUPRAC. A moderate to high mean gene diversity was observed in the panel population. Eleven significant marker-trait associations for antioxidant traits were mapped, namely, qACD2.1, qACD11.1 and qACD12.2 for DPPH; qCAT8.1 and qCAT11.1 for catalase; qFRAP11.1, qFRAP12.1 and qFRAP12.2 for FRAP; and qCUPRAC3.1, qCUPRAC11.1 and qCUPRA12.1 regulating CUPRAC. Co-localization of the QTLs for qACD11.1, qFRAP11.1 and qCUPRAC11.1 were detected, which may act as antioxidant hotspots regulating DPPH, FRAP and CUPRAC activities, respectively, while qACD12.2 and qFRAP12.1 remained close on the chromosome 12. These detected QTLs will be useful in antioxidant improvement programs in rice.
Microstructure of Croatian Wild Grapevine (Vitis vinifera subsp. sylvestris Gmel Hegi) Pollen Grains Revealed by Scanning Electron Microscopy

Wild grapevine (Vitis vinifera subsp. sylvestris Gmel Hegi) is dioecious with male and female plants, whereas domesticated grapevine is mostly hermaphrodite with self-fertile hermaphrodite flowers. The pollen morphology of wild grapevine has been poorly studied. There is no detailed palynological study of V. sylvestris in Croatia and neighboring countries. Here, scanning electron microscopy (SEM) was used to analyze the pollen of V. sylvestris from male and female individuals growing at two natural sites in Croatia. The selective APT3 marker was used to confirm the flower phenotype with the genetic background. SEM analysis showed that the pollen grains of V. sylvestris were isopolar and radially symmetrical, with foveolate perforated ornamentation, regardless of the flower type of the individuals. All male flowers were 3-colporate and prolate in shape, whereas female individuals varied from subprolate to spheroidal and had inaperturate pollen grains. Pollen shape, dimensions and exine ornamentation proved very informative, and here we address the most polymorphic traits in the analyzed V. sylvestris individuals. Principal component analysis (PCA) and clustering based on pollen morphology variables clearly differentiated individuals by their flower type, and no grouping specific to population was observed, pointing to the conserved pollen structure of V. sylvestris. The results indicate the need to continue the palynological study of V. sylvestris and serve as a good phenotypic basis for functional genetic studies on genes involved in pollen morphology and function.
Investigations of surface loads of the Earth - geometrical deformations and gravity changes

High precision geodetic determinations have demonstrated the necessity of ocean tide loading corrections. These corrections are normally obtained by convolving a proper Green’s function with an ocean tide model which predicts the tidal heights over all oceans on the Earth’s surface. However, published Green’s function formulas normally assume an observation point on a spherical Earth and are consequently not appropriate to predict corrections for an elevated observation point. In this paper, Green’s function formulas outside a spherical Earth are deduced and used to predict the gravity changes due to ocean tide loading at elevated laboratories along the Norwegian coast. The predictions are compared to gravity observations obtained with the FG5-226 absolute gravimeter in order to illustrate the effect of the modified Green’s function. Published in Kart og Plan Vol. 69(3), 2009, pages 151-164
Andrographolide Exhibits Anticancer Activity against Breast Cancer Cells (MCF-7 and MDA-MB-231 Cells) through Suppressing Cell Proliferation and Inducing Cell Apoptosis via Inactivation of ER-α Receptor and PI3K/AKT/mTOR Signaling

Breast cancer is the most common cancer among women worldwide. Chemotherapy followed by endocrine therapy is the standard treatment strategy after surgery or radiotherapy. However, breast cancer is highly resistant to the treatments leading to the recurrence of breast cancer. As a result, the development of alternative medicines derived from natural plants with fewer side effects is being emphasized. Andrographolide isolated from Andrographis paniculata is one of the potential substances with anti-cancer properties in a variety of cell types, including breast cancer cells. This study aims to investigate the anti-cancer effects of andrographolide in breast cancer cells by evaluating cell viability and apoptosis as well as its underlying mechanisms through estrogen receptor (ER)-dependent and PI3K/AKT/mTOR signaling pathways. Cell viability, cell apoptosis, mRNA or miRNA, and protein expression were examined by MTT assay, Annexin V-FITC, qRT-PCR, and Western blot analysis, respectively. MCF-7 and MDA-MB-231 cell viability was reduced in a concentration- and time-dependent manner after andrographolide treatment. Moreover, andrographolide induced cell apoptosis in both MCF-7 and MDA-MB-231 cells by inhibiting Bcl-2 and enhancing Bax expression at both mRNA and protein levels. In MCF-7 cells, the ER-positive breast cancer, andrographolide showed an inhibitory effect on cell proliferation through downregulation of ERα, PI3K, and mTOR expression levels. Andrographolide also inhibited MDA-MB-231 breast cancer cell proliferation via induction of cell apoptosis. However, the inhibition of MCF-7 and MDA-MB-231 cell proliferation of andrographolide treatment did not disrupt miR-21. Our findings showed that andrographolide possesses an anti-estrogenic effect by suppressing cell proliferation in MCF-7 cells. The effects were comparable to those of the anticancer drug fulvestrant in MCF-7 cells. This study provides new insights into the anti-cancer effect of andrographolide on breast cancer and suggests andrographolide as a potential alternative from the natural plant for treating breast cancer types that are resistant to tamoxifen and fulvestrant.
Effects of Protein and Energy Supplements on Performance of Young Bulls Offered Grass Silage

The effects of the source and concentration of protein in a barley-based supplement, and of replacing 2 kg of the daily barley supplement by 2 kg cane molasses plus 300 g of soya-bean meal were examined in finishing young bulls offered good quality grass silage ad libitum. Three experiments were carried out using suckled continental-cross bulls which were weaned at 8 months of age. Each feeding treatment consisted of 12, 9 and 10 animals in Experiments 1, 2 and 3, respectively. In Experiment 1, the supplements fed with silage were barley (B), barley plus soya-bean meal (BS) and barley plus fish meal (BF) and were designed to provide similar daily dry matter (DM) intakes. In Experiments 2 and 3 the supplements fed with silage were barley (B, low protein), barley plus soya bean meal (BS, high protein), barley plus molasses plus soya-bean meal (BM1, low pro tein), and barley plus molasses plus soya-bean meal (BM2, high protein). The four sup plements were designed to provide similar daily (DM) intakes and were isonitrogenous within the low and high protein pairs. The daily supplement allowances were given in two equal feeds. The mean duration of the experimental periods for Experiments 1, 2 and 3 were 216, 238 and 252 days, respectively, after which all animals were slaughtered. In Experiment 1, silage DM intakes for the bulls (mean initial liveweight 297 kg) on treat ments B, BS and BF were 4.29, 4.48 and 4.42 kg per day, total concentrate DM intakes were 3.81, 3.81 and 3.83 kg per day, carcass weights were 322, 320 and 319 (s.e.d. 8.8) kg, liveweight gains were 1214, 1205 and 1194 (s.e.d. 55) g per day and estimated carcass gains were 726, 719 and 707 (s.e.d. 33) g per day, respectively. The data for Experiments 2 and 3 were combined. Silage DM intakes for the bulls (mean initial liveweight 306 kg) on treatments B, BS, BM1 and BM2 were 4.33, 4.21, 4.33 and 4.37 (s.e.d. 0.23) kg per day, total concentrate DM intakes were 3.44, 3.46, 3.46 and 3.49 kg per day, carcass weights were 368, 360, 343 and 355 (s.e.d. 11) kg, liveweight gains were 1293, 1257, 1150 and 1200 (s.e.d. 52) g per day and estimated carcass gains were 808, 780, 709 and 760 (s.e.d. 34) g per day, respectively. There was no effect of either protein concentration or source on animal performance. Replacement of barley with molasses plus soya-bean meal reduced liveweight (P<0.01) and carcass weight (P<0.05) gains in Experiments 2 and 3 and resulted in poorer (P<0.05) feed conversion efficiency. An interaction (P=0.08) between energy source and protein level suggested a reduction in carcass gain from molasses inclusion at low concentrate protein intakes, but not at high protein intakes.
Intelligent Fault Detection and Classification Based on Hybrid Deep Learning Methods for Hardware-in-the-Loop Test of Automotive Software Systems

Hardware-in-the-Loop (HIL) has been recommended by ISO 26262 as an essential test bench for determining the safety and reliability characteristics of automotive software systems (ASSs). However, due to the complexity and the huge amount of data recorded by the HIL platform during the testing process, the conventional data analysis methods used for detecting and classifying faults based on the human expert are not realizable. Therefore, the development of effective means based on the historical data set is required to analyze the records of the testing process in an efficient manner. Even though data-driven fault diagnosis is superior to other approaches, selecting the appropriate technique from the wide range of Deep Learning (DL) techniques is challenging. Moreover, the training data containing the automotive faults are rare and considered highly confidential by the automotive industry. Using hybrid DL techniques, this study proposes a novel intelligent fault detection and classification (FDC) model to be utilized during the V-cycle development process, i.e., the system integration testing phase. To this end, an HIL-based real-time fault injection framework is used to generate faulty data without altering the original system model. In addition, a combination of the Convolutional Neural Network (CNN) and Long Short-Term Memory (LSTM) is employed to build the model structure. In this study, eight types of sensor faults are considered to cover the most common potential faults in the signals of ASSs. As a case study, a gasoline engine system model is used to demonstrate the capabilities and advantages of the proposed method and to verify the performance of the model. The results prove that the proposed method shows better detection and classification performance compared to other standalone DL methods. Specifically, the overall detection accuracies of the proposed structure in terms of precision, recall and F1-score are 98.86%, 98.90% and 98.88%, respectively. For classification, the experimental results also demonstrate the superiority under unseen test data with an average accuracy of 98.8%.
Factors impeding psychiatrists from promoting smoking cessation among people with serious mental illness – A mixed methods study

Abstract Psychiatrists' beliefs and behaviors regarding smoking cessation promotion among people with serious mental illness (PWSMI) have been cited as a barrier for PWSMI achieving successful abstinence. A mixed methods approach was employed to evaluate beliefs and practices of psychiatrists affiliated with a large HMO in Israel regarding smoking cessation among PWSMI. Fifty psychiatrists (43% response rate) completed a telephone survey and thirty psychiatrists interviewed using a semi-structured questionnaire. Most of the psychiatrists (84%) saw smoking cessation promotion as part of their role, but in-depth interviews revealed that only a third were routinely pro-active, with over half believing that few PWSMI are willing or capable of quitting smoking. Most of the study population felt that an attempt to quit smoking would not adversely affect their patients' mental health status, but many raised concerns regarding the safety of smoking cessation medications (SCM) amongst PWSMI. Factors associated with pro-active practice were knowledge regarding services and SCM, characteristics of patient caseload (proportion low-functioning) and psychiatrist’s smoking behavior. Psychiatrist-targeted interventions highlighting safety of SCM and promoting referral to smoking cessation services are indicated. Offering PWSMI-specific harm reduction as a first step to abstinence may offer psychiatrists an acceptable treatment alternative for the low-functioning patient.
Analysis of Radon Measurements in Relation to Daily Seismic Activity Rates in the Vrancea Region, Romania

Many previous research studies have shown how local and even regional earthquakes can significantly affect the release of radon in the soil. The aim of this work is to investigate the relationship between radon measurements and the daily seismic activity rate and develop a methodology that allows estimating the seismic activity rate using only radon measurements. To carry out this study, the earthquake catalogue of the Vrancea region (Romania) has been used to estimate the daily seismic activity rate during a given time period, in which radon measurements were also recorded, from January 2016 to September 2020. The Vrancea zone represents the most active seismic zone in Europe and is located on the eastern edge of the strongly bent Carpathian arc. In the case of the radon measurements, seasonal behaviours and linear trends due to non-seismic factors have been identified and subsequently removed. The discrete wavelet transform has been used to analyse the radon signal at two different scales: long and short periods. From the analysis carried out on a long-period scale, an approximate linear relationship has been obtained between the radon series and the daily seismic activity rate, which provides insights into the behaviour of the seismic activity in the study region with only the radon information. In addition, the study reveals certain characteristics that could be used as precursors of earthquakes at different scales: weeks in the case of the estimated daily seismic activity rate, and days in the case of the short-period signal obtained by the wavelet analysis. The results obtained for this region allow us to hope that the analysis of the radon time series can become an effective complement to the conventional seismic analysis used in operational earthquake forecasting.
Impact of Covid-19 pandemic on Remittance Inflow-Economic Growth Nexus in India: Lessons from an Asymmetric Analysis

The relentless spread of the Covid-19 pandemic from the first quarter of 2020 and the emergence of new variants since early 2021 have caused a steep decline in economic activities in all countries. The forecast by international agencies including World Bank is that remittances (REM) on a global scale would decline by 20 percent in 2021; and to South Asia in particular would decrease by 25 percent. India, a low-middle-income country, which has been among the top ten REM recipient countries, is expected to be adversely affected much more. This study examines the asymmetric effects of REM on India’s per capita GDP by using a nonlinear methodology. Additionally, factors like ICT and the financial sector are considered in an extended version of the remittance-growth relationship. The study findings reveal that the impact of the negative partial sum of decomposition of REM is higher than the impact of positive partial sum decomposition of REM, implying a greater adverse effect of declining remittances on per capita GDP growth. The findings are expected to be of substantial importance in designing appropriate policies that affect economic growth through the interaction of remittances with ICT, and financial markets.