Miracle-dz/UniFAR-FTUs huggingface dataset:
Safety Management On Loading Process With Rubber Tyred Gantry Crane : Case Study At Port Of Tanjung Priok

Loading and unloading process are the main activity that operated by PT. Pelabuhan Tanjung Priok. The operational activity occurs during fully 24 hours with very high flows. This condition affects the accident level of the area, the accident report of PT. Pelabuhan Tanjung Priok shows there are 75 case of accident by December 2015 and 45 % of the accident took place in container yard. Rubber tyred gantry crane is a tool operates in the container yard . The mobility of this tool is quite high due to wear rubber tires Thus, to prevent the study of risk assasement and its control plan of lift off process using ruberr tyred gantry crane are needed by using fault tree analysis to trace the root of the problems of each risk. the results obtained that there main activity have a highest risk, the risk is sling broken with value about 300, because of that the Lift off activities having A class from qualitative risk assesment. researcher making management recommendations of recruitment , training , tools, testing and commissioning tools, then recommendations to RTGC safety features Standard and Chart of safety report.
Random matrix, singularities and open/close intersection numbers

The s-point correlation function of a Gaussian Hermitian random matrix model, with an external source tuned to generate a multi-critical singularity, provides the intersection numbers of the moduli space for the p-th spin curves through a duality. For one marked point, the intersection numbers are expressed to all orders in the genus by Bessel functions. The matrix models for the Lie algebras of o ( N ) ? > and sp ( N ) ? > provide the intersection numbers of non-orientable surfaces. The Kontsevich–Penner model, and the higher p-th Airy matrix model with a logarithmic potential, are investigated for the open intersection numbers, which describe the topological invariants of non-orientable surfaces with boundaries. String equations for the open/closed Riemann surface are derived from the structure of the s-point correlation functions. The Gromov–Witten invariants of the CP 1 ? > model are evaluated for one marked point as an application of the present method.
Observations of the Falling Motion of Plate-Like Snow Crystals Part I: The Free-Fall Patterns and Velocity

Free-fall patterns and the variations in the vertical and horizontal velocities of unrimed plate-like snow crystals were analyzed by means of a stereo-photogrammetric method. Whether the crystals exhibit a stable falling motion or not mainly depends on the Best number, which involves the mean vertical velocity (fall velocity), and the non-dimensional moment of inertia of the crystals. Unstable fall patterns were roughly classified into three types: nonrotation, swing, and rotation or spiral. For dendritic shaped crystals, the distinction among these types is approximately determined by the combination of the non-dimensional moment of inertia and the Reynolds number, which involves the mean vertical velocity. Although the standard deviation of the vertical velocity for dendritic shaped crystals was very small (1 to 3% of the mean vertical velocity), that of the horizontal velocity was considerably larger, measuring 5 to 20% of the mean vertical velocity. Accordingly, it appears likely that the variation in the horizontal velocity plays an important role in the random aggregation of plate-like snow crystals having almost the same shape and size.
Distinct Upward Propagation of the Westerly QBO in Winter 2015/16 and Its Relationship With Brewer‐Dobson Circulation

A westerly phase of the quasi‐biennial oscillation (QBO) was disrupted in 2015/16. Previous studies have primarily focused on the cause of the localized negative momentum forcing, initiating the QBO disruption. However, the upward displacement of the westerly QBO followed by the negative momentum forcing, clearly observed in 2015/16, has received less attention. This study shows that the distinct upward propagation of the westerly winds during the 2015/16 QBO disruption was contributed by the strong Brewer‐Dobson circulation (BDC). Strong Rossby waves with wavenumber 1 propagating from the troposphere mainly drove the strong BDC. Potential contributions of El Niño and Barents–Kara sea ice reduction to Rossby waves are also discussed.
The Clinical Course of Infective Endocarditis and Independent Predictors of In-Hospital Mortality

Introduction: Despite advances in prevention, medical, and surgical treatment, the global prevalence of infective endocarditis (IE) has been gradually rising over the last two decades. However, the profile of IE varies by continent, geographic region, and hospital type. In this study, we aimed to investigate the epidemiological and clinical features of IE and to determine the factors predicting in-hospital mortality. Patients and Methods: This retrospective study was carried out at a single tertiary health care hospital in Türkiye. A total of 104 consecutive patients (>18 years old) who were hospitalized with IE between January 2016 and August 2021 were included. Modified Duke criteria were used to diagnose IE. Demographic information (age and gender), underlying heart diseases, comorbidities, causative microorganisms, blood culture results, echocardiographic findings, cardiac and extracardiac complications, surgical requirements, and in-hospital mortality were all examined. Results: The study included 104 IE cases (mean age: 57.2 ± 15.9 years; 59.6% males). Fifty-six patients (53.9%) had native valve IE, 37 patients (35.6%) had prosthetic valve IE, and four patients (3.8%) had devicerelated IE. Blood cultures were negative in 62 cases (59.6%). Staphylococcus aureus was the most common responsible microorganism in 17 patients [methicillin-sensitive Staphylococcus aureus in 13 (12.5%), methicillin-resistant Staphylococcus in four (3.8%)]. The overall in-hospital mortality rate was 30.8%. White blood cell count (OR= 1.002, 95% CI= 1.001-1.003) creatinine (OR= 1.45, 95% CI= 1.08-2.00), acute renal failure (OR= 8.60, 95% CI= 2.27-37.81), and cerebrovascular accidents (OR= 4.58, 95% CI= 1.21-18.85) were independent predictors of in-hospital mortality. Conclusion: In line with developed countries, the epidemiology and causative pathogens of IE in Türkiye have been changing. Investigating these epidemiological and clinical changes may serve as a basis for strategies to be developed for the prevention and treatment of IE.
Genomic and Epigenomic Characterization of Tumor Organoid Models

Simple Summary The patient-derived organoid (PDO) model is a versatile and dynamic tool for investigating individual genomic and epigenomic properties of cancer. PDOs preserve key (epi-)genomic features and maintain physiological and pathological characteristics, resembling patient tumor specimens. Coupled with the next-generation sequencing technology, PDOs can be used to accurately map (epi-)genomic alterations of “living” cancer specimens. Additionally, organoid modeling of matched normal and malignant tissues from the same patient serves as an adequate and valid platform to interrogate cancer-specific features. Because of these advantages, research on PDOs is rapidly growing for the investigation of genotype–phenotype association and precision oncology. Abstract Tumor organoid modeling has been recognized as a state-of-the-art system for in vitro research on cancer biology and precision oncology. Organoid culture technologies offer distinctive advantages, including faithful maintenance of physiological and pathological characteristics of human disease, self-organization into three-dimensional multicellular structures, and preservation of genomic and epigenomic landscapes of the originating tumor. These features effectively position organoid modeling between traditional cell line cultures in two dimensions and in vivo animal models as a valid, versatile, and robust system for cancer research. Here, we review recent advances in genomic and epigenomic characterization of tumor organoids and the novel findings obtained, highlight significant progressions achieved in organoid modeling of gene–drug interactions and genotype–phenotype associations, and offer perspectives on future opportunities for organoid modeling in basic and clinical cancer research.
LncRNA GAS5 Suppresses Colorectal Cancer Progress by Target miR-21/LIFR Axis

GAS5 is abnormally high in colorectal cancer tissues, which is a specific expression of lncRNA in colorectal cancer (CRC). Nevertheless, its biological function in CRC has not been elucidated. The abnormal high expression of GAS5 in CRC is the specific expression of lncRNA in CRC. The purpose of our study is to explore the effect of GAS5 on CRC and its mechanism. The expression of GAS5 in 53 paired normal and colorectal cancer tissues and colorectal cancer cell lines was detected by real-time PCR. The biological effects of GAS5, miR-21, and LIFR were measured by functional assays, including wound healing, transwell assays, and in vivo assays. We ensured the carcinogenesis role of GAS5 in CRC in the xenograft nude model. The dual-luciferase reporter assay system and chromatin immunoprecipitation method were used for target evaluation and Western blot for verification. GAS5 was significantly decreased in tumor tissues and CRC cells, and the low expression of CAS5 in CRC promoted tumor metastasis and decreased the survival of patients. GAS5 knockdown increases the cell viability, inhibits apoptosis, and promotes migration. Xenografted tumors in nude mice studies showed that GAS5 knockdown promoted tumor growth and caused worse lesions in colorectal. Furthermore, GAS5 increases the expression level of target gene LIFR to promote the apoptosis of CRC cells by binding to miR-21. Our study revealed that a novel pathway about lncRNA GAS5 inhibited the proliferation and metastasis of CRC cells by targeting miR-21/LIFR which provides a new strategy to treat CRC.
Nexus between Capital Structure and Financial Performance of Nepalese Hydropower Companies

This study aims to shed light on the empirical investigation of the nexus between capital structure and financial performance. This paper focuses on hydropower companies listed on Nepal Stock Exchange (NEPSE) until mid-July 2020. This paper analyzes the nexus of capital structure with the financial performance of hydropower companies for the period 2005/06 to 2019/20. This study applies a descriptive and causal research design. Return on equity (ROE) is used to measure financial performance and is considered a dependent variable and short-term debt to capital (SDC), long-term debt to capital (LDC), total debt to capital (TDC), and debt to assets (DR) ratios are the measures of capital structure and used as explanatory variables. This paper reveals that short-term debt to capital ratio has a positive role in financial performance. Moreover, the findings of this paper depict that long-term debt to capital and total debt to capital has a significant positive impact on the financial performance of hydropower companies in Nepal. However, the debt to asset ratio inversely affects financial performance. Thus, this paper concludes that Nepalese hydropower companies should increase short-term, long-term, and total debt to capital ratios and decrease debt to assets to maximize financial performance. The implication of this study is in the formulation of optimal capital structure policy. The hydropower sector can apply the findings of this paper to formulate an appropriate capital structure policy to maximize its financial performance in Nepal.
Does Company Size Shape Product Quality Inferences? Larger Companies Make Better High-Tech Products, but Smaller Companies Make Better Low-Tech Products

Companies vary on oft-publicized size metrics (number of employees, revenue). Do consumers prefer otherwise identical products made by larger or smaller companies? The answer hinges on whether consumers perceive the products as low-tech or high-tech. This prediction stems from a novel framework charting two lay theories regarding key resources companies utilize to provide value to consumers: employees and finances. In the intrinsic motivation lay theory, consumers believe that employees of larger (vs. smaller) companies are less intrinsically motivated. In the financial resources lay theory, consumers believe that larger (vs. smaller) companies have greater capacity to fund research and development. Critically, product type (low-tech vs. high-tech) differentially affects the accessibility of these two lay theories: For low-tech (vs. high-tech) products, the intrinsic motivation lay theory is more accessible, driving quality evaluations and choice in favor of smaller companies. For high-tech (vs. low-tech) products, the financial resources lay theory is more accessible, driving quality evaluations and choice in favor of larger companies. This research advances theory by reconciling conflicting findings regarding product quality inferences from company size metrics, with guidance for marketers to improve quality evaluations and choice shares by strategically supporting or challenging lay theories and shifting perceptions of company size or product type.
NaCl-Assisted Chemical Vapor Deposition of Large-Domain Bilayer MoS2 on Soda-Lime Glass

In recent years, two-dimensional molybdenum disulfide (MoS2) has attracted extensive attention in the application field of next-generation electronics. Compared with single-layer MoS2, bilayer MoS2 has higher carrier mobility and has more promising applications for future novel electronic devices. Nevertheless, the large-scale low-cost synthesis of high-quality bilayer MoS2 still has much room for exploration, requiring further research. In this study, bilayer MoS2 crystals grown on soda-lime glass substrate by sodium chloride (NaCl)-assisted chemical vapor deposition (CVD) were reported, the growth mechanism of NaCl in CVD of bilayer MoS2 was analyzed, and the effects of molybdenum trioxide (Mo) mass and growth pressure on the growth of bilayer MoS2 under the assistance of NaCl were further explored. Through characterization with an optical microscope, atomic force microscopy and Raman analyzer, the domain size of bilayer MoS2 prepared by NaCl-assisted CVD was shown to reach 214 μm, which is a 4.2X improvement of the domain size of bilayer MoS2 prepared without NaCl-assisted CVD. Moreover, the bilayer structure accounted for about 85%, which is a 2.1X improvement of bilayer MoS2 prepared without NaCl-assisted CVD. This study provides a meaningful method for the growth of high-quality bilayer MoS2, and promotes the large-scale and low-cost applications of CVD MoS2.
Salivary Gland Adaptation to Dietary Inclusion of Hydrolysable Tannins in Boars

Simple Summary Tannins have traditionally been avoided in animal nutrition due to their anti-nutritive effects. However, recent studies reported hydrolysable tannins as beneficial additives that have antimutagenic, anticarcinogenic, antidiarrheal, and antiulcerogenic effects on animals. In a study testing the inclusion of hydrolysable tannins as a potential nutritive factor to reduce boar taint in entire males, significant enlargement of the parotid glands (parotidomegaly) was observed. In this study, we aimed to determine the morphological and immunohistochemical basis for the observed parotidomegaly. We discovered that enlargement of glandular lobules and acinar area, an increased ratio between the nucleus and cytoplasm of serous cells, and increased excretion of proline-rich proteins (PRPs) were characteristic of the experimental group that received the highest dietary tannin intake. The mandibular salivary gland, on the other hand, did not show significant morphological changes among the experimental groups. This suggests increased functional activity of the parotid salivary glands as the first and most important line of defense against high dietary tannin and its potential negative effects. Abstract The ingestion of hydrolysable tannins as a potential nutrient to reduce boar odor in entire males results in the significant enlargement of parotid glands (parotidomegaly). The objective of this study was to characterize the effects of different levels of hydrolysable tannins in the diet of fattening boars (n = 24) on salivary gland morphology and proline-rich protein (PRP) expression at the histological level. Four treatment groups of pigs (n = 6 per group) were fed either a control (T0) or experimental diet, where the T0 diet was supplemented with 1% (T1), 2% (T2), or 3% (T3) of the hydrolysable tannin-rich extract Farmatan®. After slaughter, the parotid and mandibular glands of the experimental pigs were harvested and dissected for staining using Goldner’s Trichrome method, and immunohistochemical studies with antibodies against PRPs. Morphometric analysis was performed on microtome sections of both salivary glands, to measure the acinar area, the lobular area, the area of the secretory ductal cells, and the sizes of glandular cells and their nuclei. Histological assessment revealed that significant parotidomegaly was only present in the T3 group, based on the presence of larger glandular lobules, acinar areas, and their higher nucleus to cytoplasm ratio. The immunohistochemical method, supported by color intensity measurements, indicated significant increases in basic PRPs (PRB2) in the T3 and acidic PRPs (PRH1/2) in the T1 groups. Tannin supplementation did not affect the histo-morphological properties of the mandibular gland. This study confirms that pigs can adapt to a tannin-rich diet by making structural changes in their parotid salivary gland, indicating its higher functional activity.
Influence of Successors’ Socio-demographic Characteristics on Performance of Family-Owned Small and Medium Enterprises in Tanzania

This study examined the influence of successors’ socio-demographic characteristics on the performance of family-owned Small and Medium Enterprises. Probability sampling technique was employed to obtain sample of 219 successors. The hierarchical regression model and independent samples t-test were employed to test the study hypotheses. The findings of this study indicate that successors’ socio-demographic characteristics, that is, education and business experience have influence on performance of family-owned Small and Medium Enterprises and there is no statistical difference in performance in terms of profit between male and female successors. It was concluded that for performance of family-owned SMEs successor’s sex should not be a factor for consideration in selecting a successor in family-owned SMEs. For good performance of family business, successors’ socio-demographic characteristics mainly education and business experience should be given priority in succession plan. The paper recommends that, to reduce the reported high failure rate, family business founders should strengthen their successors’ socio-demographic characteristics, mainly education and business experience instead of building on sex as the only criteria for successors’ selection.
Characterization of Philadelphia-like Pre-B Acute Lymphoblastic Leukemia: Experiences in Mexican Pediatric Patients

Ph-like subtypes with CRLF2 abnormalities are frequent among Hispano–Latino children with pre-B ALL. Therefore, there is solid ground to suggest that this subtype is frequent in Mexican patients. The genomic complexity of Ph-like subtype constitutes a challenge for diagnosis, as it requires diverse genomic methodologies that are not widely available in diagnostic centers in Mexico. Here, we propose a diagnostic strategy for Ph-like ALL in accordance with our local capacity. Pre-B ALL patients without recurrent gene fusions (104) were classified using a gene-expression profile based on Ph-like signature genes analyzed by qRT-PCR. The expressions of the CRLF2 transcript and protein were determined by qRT-PCR and flow cytometry. The P2RY8::CRLF2, IGH::CRLF2, ABL1/2 rearrangements, and Ik6 isoform were screened using RT-PCR and FISH. Surrogate markers of Jak2-Stat5/Abl/Ras pathways were analyzed by phosphoflow. Mutations in relevant kinases/transcription factors genes in Ph-like were assessed by target-specific NGS. A total of 40 patients (38.5%) were classified as Ph-like; of these, 36 had abnormalities associated with Jak2-Stat5 and 4 had Abl. The rearrangements IGH::CRLF2, P2RY8::CRLF2, and iAMP21 were particularly frequent. We propose a strategy for the detection of Ph-like patients, by analyzing the overexpression/genetic lesions of CRLF2, the Abl phosphorylation of surrogate markers confirmed by gene rearrangements, and Sanger sequencing.
Association between Obesity, Overweight, Elevated Waist Circumference, and Insulin Resistance Markers among Brazilian Adolescent Students

(1) Background: There is still controversy concerning the most effective and efficient strategy to identify insulin resistance in adolescents. We estimated the level of fasting insulin (fasting insulin equivalent, FIeq) that would replicate the strength of the associations of obesity, overweight, and waist circumference with two insulin resistance markers: triglyceride/high-density lipoprotein (TG/HDL) and triglyceride/glucose (TyG); (2) Methods: We studied approximately 38,000 adolescents aged 12 to 17 years, sampled from a multicenter Brazilian school-based survey, The Study of Cardiovascular Risk Factors in Adolescents (Portuguese acronym, ERICA), conducted in 2013–2014. Fasting insulin equivalents for adiposity variables were calculated by dividing the beta coefficient of each adiposity measure by the fasting insulin beta coefficient from linear regression analysis according to age (12–14, 15–17 years old) and sex, and adjusted by smoking, alcohol consumption, physical inactivity, sedentary behavior, socioeconomic status, and Tanner stage; (3) Results: The FIeqs for obesity were greater than those for overweight and elevated waist circumference for both TG/HDL and TyG in early adolescence. The FIeqs for elevated WC were greater than those for obesity and overweight in adolescents aged 15 to 17 years; (4) Conclusions: Our study suggests that WC measurements might be useful to identify adolescents with insulin resistance, particularly in late adolescence.
A Self-Sustained Mass Sensor With Physical Closed Loop Based on Thermal-Piezoresistive Coupled Resonators

This article reports a mode-localized mass sensor based on thermal-actuation piezoresistive-detection self-oscillated weakly coupled resonators. Detailed theoretical models and simulations of the self-oscillation of the coupled resonators were established and were also verified using optical and electrical measurements. The sensor was fabricated and characterized in terms of stability, linearity, sensitivity, and resolution. Supplied with only a constant direct current (DC), the resonant mass sensor could oscillate at its resonant frequency with an ultrahigh quality factor of 95 k in air. By implementing the principle of the mode localization phenomenon, ~200 times parametric sensitivity improvement with amplitude ratio output was implemented compared to the traditional frequency output metric. A real-time mass detector with 84-fg resolution and larger than ~700-pg linear measurement range was obtained.