Miracle-dz/UniFAR-FTUs huggingface dataset:
Green Biofabrication of Silver Nanoparticles of Potential Synergistic Activity with Antibacterial and Antifungal Agents against Some Nosocomial Pathogens

Nosocomial bacterial and fungal infections are one of the main causes of high morbidity and mortality worldwide, owing to the high prevalence of multidrug-resistant microbial strains. Hence, the study aims to synthesize, characterize, and investigate the antifungal and antibacterial activity of silver nanoparticles (AgNPs) fabricated using Camellia sinensis leaves against nosocomial pathogens. The biogenic AgNPs revealed a small particle diameter of 35.761 ± 3.18 nm based on transmission electron microscope (TEM) graphs and a negative surface charge of −14.1 mV, revealing the repulsive forces between nanoparticles, which in turn indicated their colloidal stability. The disk diffusion assay confirmed that Escherichia coli was the most susceptible bacterial strain to the biogenic AgNPs (200 g/disk), while the lowest sensitive strain was found to be the Acinetobacter baumannii strain with relative inhibition zones of 36.14 ± 0.67 and 21.04 ± 0.19 mm, respectively. On the other hand, the biogenic AgNPs (200 µg/disk) exposed antifungal efficacy against Candida albicans strain with a relative inhibition zone of 18.16 ± 0.14 mm in diameter. The biogenic AgNPs exposed synergistic activity with both tigecycline and clotrimazole against A. baumannii and C. albicans, respectively. In conclusion, the biogenic AgNPs demonstrated distinct physicochemical properties and potential synergistic bioactivity with tigecycline, linezolid, and clotrimazole against gram-negative, gram-positive, and fungal strains, respectively. This is paving the way for the development of effective antimicrobial combinations for the effective management of nosocomial pathogens in intensive care units (ICUs) and health care settings.
A Discrete Inverse Scattering Transform for Q3$_\delta$

We derive a fully discrete Inverse Scattering Transform as a method for solving the initial-value problem for the Q3$_\delta$ lattice (difference-difference) equation for real-valued solutions. The initial condition is given on an infinite staircase within an N-dimensional lattice and must obey a given summability condition. The forward scattering problem is one-dimensional and the solution to Q3$_\delta$ is expressed through the solution of a singular integral equation. The solutions obtained depend on N discrete independent variables and N parameters.
Differences between the Pallas collisional family and similarly sized B-type asteroids ?

Context. B-type asteroids constitute a peculiar spectral class within the C-complex. Previous work has pointed out the difference between the visible geometric albedos of B-types and those of the Pallas collisional family (PCF), whose few members with observed spectra are B-types (one exception out of eight objects). This has been interpreted as being due to compositional differences. However, the PCF members are typically smaller than the spectroscopically classified B-types, and the following possibilities have not been ruled out: the albedo differences might be related to a size-albedo dependence and/or to the generally larger errors of the WISE data and best-fitting values of the derived parameters expected for smaller objects. Aims. We compare albedos and beaming parameters of PCF members and B-types of similar sizes and re-examine our conclusion on the different composition of the PCF. Methods. By modelling their WISE/NEOWISE data, we derived sizes and albedos of all objects whose Sloan Digital Sky Survey reflectances are similar to the typical B-type reflectance spectra. In particular, we derived the so-called infrared beaming parameters ( η ), effective diameters ( D ), and corresponding visible geometric albedos ( p V ), and studied their value distributions. Results. We obtained the effective diameter and geometric visible albedo for ~600 B-type asteroids whose sizes range between 2 and 100 km, approximately half of which have fitted η -values that are inversely correlated to size. We found that the albedo distributions of the PCF is significantly different from that of other B-types in the same size range (2−20 km), and we rule out any size-albedo dependency or biases related to the lower quality of the p V -values of smaller objects. In addition, we also found differences between the η -value distribution of the PCF and the other similarly-sized B-types. Conclusions. The differences in the visible albedos of PCF members and the other B-types of similar sizes is a strong indication that their compositions are different. The trend between beaming parameter and size of the B-types (excluding the PCF) is consistent with the expectation that the surfaces of smaller asteroids have coarser rocks than do those of larger objects ( D > 40 km), which are thought to be covered by a finer, more insulating layer of dust.
Intraluminal Therapy for Helicobacter pylori Infection—Comparison of Medicament Containing Tetracycline, Metronidazole, and Bismuth versus Amoxicillin, Metronidazole, and Clarithromycin: A Randomized Controlled Study

Helicobacter pylori (H. pylori) can be eradicated immediately via local application of single-dose medicament on endoscopic examination. In our previous report, “the eradication rate of intraluminal therapy for H. pylori infection (ILTHPI) is 53.7% (51/95) using medicament containing amoxicillin, metronidazole, and clarithromycin”. We aimed to evaluate the efficacy and adverse events of medicament containing tetracycline, metronidazole, and bismuth and to improve the efficacy of stomach acid control before ILTHPI. After usage of dexlansoprazole (60 mg b.i.d.) or vonoprazan (20 mg q.d.) for 3 days before ILTHPI, 103 of 104 (99.1%) symptomatic H. pylori-infected treatment-naïve patients achieved levels of stomach pH ≥ 6. Patients were randomized to receive ILTHPI with medicaments containing tetracycline, metronidazole, and bismuth (Group A, n = 52) or amoxicillin, metronidazole, and clarithromycin (Group B, n = 52). The eradication rate of ILTHPI was similar between Group A (76.5%; 39/51) and Group B (84.6%, 44/52) (p = 0.427) and the adverse event was mild diarrhea (2.9%; 3/104). The eradication rate significantly increased from 53.7% (51/95) to 84.6% (44/52) after acid control (p = 0.0004) for Group B patients. The overall eradication rates of successful ILTHPI plus 7-day non-bismuth (Group A) or 7-day bismuth (Group B) oral quadruple therapy for ILTHPI failure patients were both excellent (96.1% for Group A and 98.1% for Group B).
Pricing of long dated equity-linked life insurance contracts

Abstract This article adopts an approach to pricing of equity-linked life insurance contracts, which only requires the existence of the numéraire portfolio. An equity-linked life insurance contract is equivalent to a sum of the guaranteed amount and the value of an option on the equity index with some mortality risk attached. The numéraire portfolio equals the growth optimal portfolio and is used as numéraire or benchmark, where the real-world probability measure is taken as pricing measure. To obtain tractable solutions the short rate is modelled as a quadratic form of some Gaussian factor processes. Furthermore, the dynamics of the mortality rate is modelled as a threshold life table. The dynamics of the discounted equity market index or benchmark is modelled by a time transformed squared Bessel process. The equity-linked life insurance contracts are evaluated analytically.
Investment Efficiency and Earnings Quality: European Evidence

This study aims to analyze the relationship between earnings quality and investment efficiency in the European context, in order to understand whether higher earnings quality mitigates investment inefficiencies. To further understand the relationship between earnings quality and investment efficiency, the roles of cash and financial constraints are also analyzed. We use firm-year data based on unbalanced panel data, and control for country, year, and industry fixed effects using a sample composed of listed and unlisted European companies from 19 countries and 17 industries for the period 2010–2018. The results show a positive and significant relationship between earnings quality and investment efficiency. In both scenarios of investment inefficiency, overinvestment and underinvestment, the results suggest that a higher quality of reported earnings mitigates investment inefficiencies. The results also suggest that the negative relationship holds for cash-constrained and unconstrained firms, and that in firms that are financially unconstrained (higher levels of cash and lower levels of leverage) the combined effect with earnings quality is associated with a lower investment efficiency.
Revisiting the Role of NAG across the Continuum of Kidney Disease

Acute and chronic kidney diseases are an evolving continuum for which reliable biomarkers of early disease are lacking. The potential use of glycosidases, enzymes involved in carbohydrate metabolism, in kidney disease detection has been under investigation since the 1960s. N-acetyl-beta-D-glucosaminidase (NAG) is a glycosidase commonly found in proximal tubule epithelial cells (PTECs). Due to its large molecular weight, plasma-soluble NAG cannot pass the glomerular filtration barrier; thus, increased urinary concentration of NAG (uNAG) may suggest injury to the proximal tubule. As the PTECs are the workhorses of the kidney that perform much of the filtration and reabsorption, they are a common starting point in acute and chronic kidney disease. NAG has previously been researched, and it is widely used as a valuable biomarker in both acute and chronic kidney disease, as well as in patients suffering from diabetes mellitus, heart failure, and other chronic diseases leading to kidney failure. Here, we present an overview of the research pertaining to uNAG’s biomarker potential across the spectrum of kidney disease, with an additional emphasis on environmental nephrotoxic substance exposure. In spite of a large body of evidence strongly suggesting connections between uNAG levels and multiple kidney pathologies, focused clinical validation tests and knowledge on underlining molecular mechanisms are largely lacking.
Seed removal, seed dispersers, and the allocation of tissues in Myrtaceae seeds

To avoid seed predation, plants may invest in protective seed tissues. Often related to seed size, allocation in seeds' physical defenses can also be influenced by dispersers. We explore the relationships between seed traits (seed mass and hardness) and seed removal in 22 Myrtaceae species of the Brazilian Atlantic Forest, a dominant and diverse fleshy‐fruited taxon dispersed by birds, rodents, and other mammals. Our goal is to understand how seed traits influence seed removal rates, and whether dispersers can affect tissue allocation in the seed coat. Seeds were exposed to field removal experiments. In the laboratory, total seed mass and seed coat mass were obtained. To evaluate the influence of seed traits on removal, we performed Kruskal–Wallis and Simple Linear Regression tests. We assessed seed coat and seed mass covariation through standardized major‐axis allometric regressions. Harder seeds were larger than softer ones. Seed traits affect removal rates, as tougher and heavier seeds had lower removal. Seed mass significantly predicts seed coat proportion in seven of the 14 species tested. Bird‐dispersed species tend to exhibit lower proportions of seed coat as seed mass increases, whereas rodent‐dispersed species apparently present the opposite trend, with seed coat proportion increasing with seed mass. Such difference may be caused by the contrasting seed predation pressure represented by birds and rodents. Energy allocation for defense, expressed in seed coat proportion, is greater in large seeds, as these are mostly dispersed by rodents whose propensity to cache and disperse seeds is greater for large and well‐protected seeds.
PHYSICAL MODELING OF BREACH FORMATION Large scale field tests

During extreme flooding and internal erosion failure events, detailed data on flow and formation processes of breaches through embankments/dams are rarely recorded. Consequently, to support numerical model development, testing, and verification, field and laboratory tests of embankment breaches created through overtopping and piping have been conducted. Controlled field tests of rock fill, clay, and glacial moraine embankments, 5-6 m high, have been conducted in Northern Norway. The large-scale field tests are both part of a Norwegian research project called Stability and Breaching of Embankments Dams and an EC project called IMPACT. Laboratory tests of sand, and clay embankments, 0.5 0.6 m high (i.e. scale of 1:10) have also been conducted in a large flume at HR Wallingford, UK. This work is presented in a companion paper. An overview and initial observations/conclusions from the large-scale field tests are presented in this paper.
Resonance enhanced absorption in a graphene monolayer using deep metal gratings

It has been demonstrated recently that metal gratings can significantly improve the near-infrared absorptance of graphene from 0.023 to nearly 0.70 because of the excitation of magnetic polaritons (MPs). In the present study, it is shown that the absorptance of graphene can be further enhanced to more than 0.80 by surface plasmon polaritons (SPPs) enabled by the grating. Meanwhile, graphene behaves as a sheet resistor that is able to boost the absorption when MPs or SPPs are excited without changing their resonance frequencies or dispersion relations. The effects of higher-order MPs, as well as the grating geometry on the enhanced absorptance, are also examined. Rigorous coupled-wave analysis (RCWA) is employed to calculate the radiative properties and power dissipation density in both the graphene and the metal grating. This study will facilitate the understanding of the coupling phenomena between graphene and nanostructures and may also benefit the design of next-generation graphene-based optical and optoelectronic devices.
Stochastic comparisons of largest claim and aggregate claim amounts

In this paper, we establish some stochastic comparison results for largest claim amounts of two sets of independent and also for interdependent portfolios under the setup of the proportional odds model. We also establish stochastic comparison results for aggregate claim amounts of two sets of independent portfolios. Further, stochastic comparisons for largest claim amounts from two sets of independent multiple-outlier claims have also been studied. The results we obtained apply to the whole family of extended distributions, also known as the Marshall–Olkin family of distributions. We have given many numerical examples to illustrate the results obtained.
Enhancing the performance of direct seeded basmati rice through seed priming and nitrogen management

Field experiment was conducted at Punjab Agricultural University Ludhiana to enhance the performance of dry direct seeded basmati rice with 20 treatment combination in split plot design viz. five nitrogen levels and timing in main plots [0, 40 kg ha−1 (2 and 3 splits), 60 kg ha−1 (2 and 3 splits)] and four seed priming treatments (control, osmohardening, water hardening and hydropriming). The direct seeded Pusa Basmati 1121 responded upto 60 kg ha−1 of N applied in 3 splits (21, 42 and 63 days after sowing) and resulting higher grain yield, milled and head rice recovery%, KLAC and elongation ratio than 40 kg ha−1 of N application applied in 2 or 3 splits. Crop with hydropriming gave superior performance as compared to other seed priming treatments. Highest grain yield of Pusa Basmati 1121 was obtained with hydropriming at 60 kg ha−1 of N application applied in 3 splits.
Microvasculature Features Derived from Hybrid EPI MRI in Non-Enhancing Adult-Type Diffuse Glioma Subtypes

Simple Summary Reliable insight into tumor microvasculature is important for monitoring disease progression and treatment response. Vessel size imaging (VSI), an emerging MRI technique, has shown great potential in revealing accurate information about microvasculature in gliomas. However, the technique has rarely been used in the clinical setting, as investigated here. Of note, our work was only aimed at non-enhancing tumors. This sets our work apart from other studies investigating tumor microvasculature, typically including enhancing tumors, i.e., tumors in which angiogenesis is already evident macroscopically. Additionally, our findings are of potential clinical relevance for differentiating the most aggressive tumor subtype, glioblastoma, from two other glioma subtypes: oligodendroglioma and astrocytoma. This is particularly challenging when there is no contrast enhancement. Abstract In this study, we used the vessel size imaging (VSI) MRI technique to characterize the microvasculature features of three subtypes of adult-type diffuse glioma lacking enhancement. Thirty-eight patients with confirmed non-enhancing glioma were categorized into three subtypes: Oligo (IDH-mut&1p/19q-codeleted), Astro (IDH-mut), and GBM (IDH-wt). The VSI technique provided quantitative maps of cerebral blood volume (CBV), microvasculature (µCBV), and vessel size for each patient. Additionally, tissue samples of 21 patients were histopathologically analyzed, and microvasculature features were quantified. Both MRI- and histology-derived features were compared across the three glioma subtypes with ANOVA or Kruskal–Wallis tests. Group averages of CBV, μCBV, and vessel size were significantly different between the three glioma subtypes (p < 0.01). Astro (IDH-mut) had a significantly lower CBV and µCBV compared to Oligo (IDH-mut&1p/19q-codeleted) (p = 0.004 and p = 0.001, respectively), and a higher average vessel size compared to GBM (IDH-wt) (p = 0.01). The histopathological analysis showed that GBM (IDH-wt) possessed vessels with more irregular shapes than the two other subtypes (p < 0.05). VSI provides a good insight into the microvasculature characteristics of the three adult-type glioma subtypes even when lacking enhancement. Further investigations into the specificity of VSI to differentiate glioma subtypes are thus warranted.
New records and distribution of three taxa in Korea: Leuzea chinensis (Asteraceae), Symplocos nakaharae (Symplocaceae), and Epilobium parviflorum (Onagraceae)

Leuzea chinensis (S. Moore) Susanna (Asteraceae), a previously unrecorded species in Korea, was found in Yeongdeok-gun, Gyeongsangbuk-do. Symplocos nakaharae (Hayata) Masam. (Symplocaceae), which had been recorded in the literature but whose native habitat was yet to be identified, was found in Geojedo Island, Gyeongsangnam-do. It was confirmed that Epilobium parviflorum Schreb. (Onagraceae) grew naturally on the islands of Jeollanam-do. Detailed morphological descriptions and geographical distribution of the three taxa are provided.
In Vitro Screening Studies on Eight Commercial Essential Oils-Derived Compounds to Identify Promising Natural Agents for the Prevention of Osteoporosis

Over the years, essential oils (EOs) and their compounds have gained growing interest due to their anti-inflammatory, antimicrobial, antioxidant, and immunomodulatory properties. The aim of this study was to evaluate the effect of eight commercially available EO-derived compounds ((R)-(+)-limonene, (S)-(−)-limonene, sabinene, carvacrol, thymol, alpha-pinene (α-pinene), beta-pinene (β-pinene), and cinnamaldehyde) on the bone formation process in vitro to select the most promising natural agents that could potentially be used in the prevention or treatment of osteoporosis. Within this study, evaluation of cytotoxicity, cell proliferation, and osteogenic differentiation was performed with the use of mouse primary calvarial preosteoblasts (MC3T3-E1). Moreover, extracellular matrix (ECM) mineralization was determined using MC3T3-E1 cells and dog adipose tissue-derived mesenchymal stem cells (ADSCs). The two highest non-toxic concentrations of each of the compounds were selected and used for testing other activities. The conducted study showed that cinnamaldehyde, thymol, and (R)-(+)-limonene significantly stimulated cell proliferation. In the case of cinnamaldehyde, the doubling time (DT) for MC3T3-E1 cells was significantly shortened to approx. 27 h compared to the control cells (DT = 38 h). In turn, cinnamaldehyde, carvacrol, (R)-(+)-limonene, (S)-(−)-limonene, sabinene, and α-pinene exhibited positive effects on either the synthesis of bone ECM or/and mineral deposition in ECM of the cells. Based on the conducted research, it can be assumed that cinnamaldehyde and (R)-(+)-limonene are the most promising among all tested EO-derived compounds and can be selected for further detailed research in order to confirm their biomedical potential in the chemoprevention or treatment of osteoporosis since they not only accelerated the proliferation of preosteoblasts, but also significantly enhanced osteocalcin (OC) synthesis by preosteoblasts (the OC level was approx. 1100–1200 ng/mg compared to approx. 650 ng/mg in control cells) and ECM calcification of both preosteoblasts and mesenchymal stem cells. Importantly, cinnamaldehyde treatment led to a three-fold increase in the mineral deposition in ADSCs, whereas (R)-(+)-limonene caused a two-fold increase in the ECM mineralization of both MC3T3-E1 cells and ADSCs.
Possible Points of Ulnar Nerve Entrapment in the Arm and Forearm: An Ultrasound, Anatomical, and Histological Study

Background: Ulnar nerve entrapment is one of the most common entrapment neuropathies, usually occurring in the cubital tunnel of the elbow and in Guyon’s canal of the wrist. However, it can also occur at other anatomical locations. Purpose: Our aim was to review other possible locations of ulnar nerve entrapment in an ultrasound and anatomical study. Material and Methods: Eleven upper limbs from eight adult corpses were ultrasonographically examined and subsequently dissected in a dissection laboratory. Four specific anatomical points were analysed, and any anatomical variations were documented. Moreover, six samples of the nerve were taken for histological analysis. Results: Distinct anatomical relationships were observed during ultrasound and dissection between the ulnar nerve and the medial intermuscular septum, the triceps aponeurosis, Osborne’s fascia at the elbow, the arcuate ligament of Osborne and the intermuscular aponeurosis between the flexor carpi ulnaris and the flexor digitorum superficialis muscles. A statistical study showed that these locations are potential areas for ulnar nerve compression. In addition, a fourth head of the triceps brachii muscle was found in some specimens. Conclusion: Results demonstrate that ultrasound is a good tool to investigate ulnar nerve entrapment neuropathy and to identify other anatomical points where the nerve can remain compressed.
Intervention analysis with control groups

Des groupes de controle peuvent etre utilises lorsqu'il y a des observations de series temporelles. Cependant, il semblerait que dans la literature, il n'y ait pas de traitement systematique des problemes statistiques associes. Des modeles structurels de series temporelles sont formules en termes de composantes inobservables telles que des trends et des effets saisonniers qui ont une interpretation directe. On montre que les modeles structurels multivaries de series temporelles constituent un cadre ideal pour l'analysis d'interventions avec des groupes de controle. Ces demiers facilitent aussi l'analyse des gains potentiels dus a l'utilisation des groupes de controle et des conditions sous lesquelles l'estimation d'une unique equation est valide.