Miracle-dz/UniFAR-FTUs huggingface dataset:
A conceptual model of multi-scale formation processes of open-air Middle Paleolithic sites in the arid Negev desert, Israel

Abstract Open-air surface accumulations and scatters of material cultural remains often are perceived as less-reliable archaeological archives, where it is difficult to distinguish anthropogenic versus geogenic formation processes or to assess their specific effects on the integrity of archaeological records. Here we analyze the depositional histories of three Middle Paleolithic open-air sites in the Negev desert of Israel, combining archaeological and geomorphological methods to create a conceptual model of multi-scale effects on the archaeological remains. Relying on the long research history in archaeology and geomorphology in the Negev, we show that integration of archaeological and geomorphological methodologies provides nuanced insights to our understanding of the archaeological record. The links established between regional and local geomorphic processes and lithic taphonomy by applying such a multi-scale analysis further allow back-tracking environmental processes from flint taphonomic attributes. Placing each site within the range of regional and local processes of exposure and burial by using informed and critically evaluated data helps to create a robust regional archaeological data base. We suggest that our approach is useful in other arid zone contexts and may have implications for understanding Pleistocene population movements across such regions.
Physical Activity and Self-Efficacy on Exercise among Elderly Retired Philippine Army: Basis for Policy-making on Physical Activity Program

This study aimed to investigate the physical activity and the level of self-efficacy in relation to exercise among the retired Philippine Army based in the province of Zamboanga del Norte, Philippines during the months of May and June 2023. A quantitative descriptive-correlational design was utilized in the study. Data were gathered from 19 retired Philippine Army personnel during the Armed Forces Veteran Association- Zamboanga del Norte’s monthly meeting. Frequency count, weighted mean and Pearson Correlation was used to analyze the collected data. The study found out that there was no significant relationship between physical activity on age, gender and length of service. It was also noted that there was a positive correlation between the variables age, gender and length of service this suggests that if there were changes in the variable physical activity, all other variables would change on the same direction. Moreover, Results showed that age and gender had a significant relationship as well as age and self-efficacy as both relationships showed a positive correlation. However, length of service and self-efficacy does not show significant relationship because of its negative correlation. Furthermore, results show no significant relationship between physical activity and the level of self-efficacy among Armed Forces veterans in Zamboanga del Norte. The results revealed a positive correlation which indicates that when the variable self-efficacy changes, the variable physical activity also changes on the same direction.
Early outcome analysis of arthroscopic anterior cruciate ligament reconstruction using fixed closed loop and adjustable loop techniques: A prospective case series

CONTEXT: Anterior cruciate ligament (ACL) reconstruction has remained the gold standard for ACL injuries, especially for young individuals and athletes expose to high-level sporting activities aiming to return preinjury level of activity. Femoral cortical suspension devices have gained popularity. However, there are limited studies specifying a superior graft fixation technique. AIMS: To evaluate outcome of arthroscopic ACL reconstruction using fixed closed loop fixation (CLF) and adjustable loop fixation (ALF) techniques. SETTINGS AND DESIGN: Prospective case series. MATERIALS AND METHODS: 40 cases were included in the study, among of which 20 cases, underwent arthroscopic CLF and another group of 20, who were operated on using ALF. Clinical outcome was assessed using manual tests, i.e., Lachman and pivot shift, and results were graded using the International Knee Documentation Committee. Lysholm score was used to evaluate functional outcome up to 6 months. STATISTICAL ANALYSIS USED: Data were analyzed using SPSS version 21. RESULTS: There were no significant differences in manual Lachman and pivot shift grading in both groups. One case (5%) in CLF group and 15% in ALF group were showed Grade B clinically laxity by Lachman, and one case (5%) in CLF group and 10% in ALF group were showed Grade 2 + rotatory laxities by pivot shift. The study found no statistically significant differences in functional score between the groups (P = 0.245). CONCLUSIONS: In femoral fixation of ACL graft both CLF and ALF techniques may provide secure fixation, equal reduction of graft laxity, and similar functional outcome in ACL deficient knee.
Formation of star clusters: Models and simulations

Abstract Recent progress is reviewed in describing the physical processes of star cluster formation, from the viewpoint of theoretical models and numerical simulations. In many studies, supersonic turbulent flows structure the gas into a network of clumps, filaments, and cores. Self-gravity drives star formation, moderated by turbulence, magnetic fields, and stellar feedback. Recent models and simulations describe the core mass function, the protostar mass function, and the star-formation rate. Several simulations indicate similar protostar birthrates, a mass advantage for firstborn protostars, and accretion rates that are superthermal and nearly constant. Recently observed core-filament systems with sonic line widths and parsec lengths present challenges for turbulent models.
Molecular Mechanisms Behind Vascular Mimicry as the Target for Improved Breast Cancer Management

Introduction Breast cancer has a high incidence and mortality rate in women due to metastasis and drug resistance which is associated with vasculogenic mimicry (VM). We purposed to explore VM formulation in breast cancer and mechanism of which is involved in EphA2/PIK3R1/CTNNB1 in the present study. Methods The expression of EphA2/PIK3R1/CTNNB1 and breast cancer patient prognosis was analyzed from TCGA data, both gene and protein expression as well as VM were measured in human breast cancer tissue samples collected in our study. The relationship between EphA2/PIK3R1/CTNNB1 and the formation of VM in breast cancer and its possible regulatory mechanism was explored. Results The results of the bioinformatics analysis based on TCGA showed that the expression of PIK3R1/ CTNNB1/ PECAM1 (CD31) in tumor tissues was significantly lower than that in normal tissues. EphA2 was positively correlated with PIK3R1, PIK3R1 with CTNNB1, and CTNNB1 with PECAM1 expression in breast cancer tissues. The results of detection in breast cancer and adjacent tissues indicated that the expression of EphA2/PIK3R1/CTNNB1 in cancer tissues was significantly lower than that in adjacent tissues. The expression of PIK3R1 was positively correlated with EphA2 and CTNNB1 expression, respectively, as well as EphA2 expression correlated with CTNNB1 expression positively. VM formation was significantly increased in breast cancer tissues compared with adjacent tissues. Conclusion Our results suggested that the formation of VM in breast cancer may be related to the EphA2/PIK3R1/CTNNB1 molecular signaling pathway.
Thermo‐hydrodynamic‐mechanical multiphase flow model for CO2 sequestration in fracturing porous media

In this paper, we introduce a fully coupled thermo‐hydrodynamic‐mechanical computational model for multiphase flow in a deformable porous solid, exhibiting crack propagation due to fluid dynamics, with focus on CO2 geosequestration. The geometry is described by a matrix domain, a fracture domain, and a matrix‐fracture domain. The fluid flow in the matrix domain is governed by Darcy's law and that in the crack is governed by the Navier–Stokes equations. At the matrix‐fracture domain, the fluid flow is governed by a leakage term derived from Darcy's law. Upon crack propagation, the conservation of mass and energy of the crack fluid is constrained by the isentropic process. We utilize the representative elementary volume‐averaging theory to formulate the mathematical model of the porous matrix, and the drift flux model to formulate the fluid dynamics in the fracture. The numerical solution is conducted using a mixed finite element discretization scheme. The standard Galerkin finite element method is utilized to discretize the diffusive dominant field equations, and the extended finite element method is utilized to discretize the crack propagation, and the fluid leakage at the boundaries between layers of different physical properties. A numerical example is given to demonstrate the computational capability of the model. It shows that the model, despite the relatively large number of degrees of freedom of different physical nature per node, is computationally efficient, and geometry and effectively mesh independent. Copyright © 2017 John Wiley & Sons, Ltd.
Data-Driven Approximation of Contextual Chance-Constrained Stochastic Programs

Uncertainty in classical stochastic programming models is often described solely by independent random parameters, ignoring their dependence on multidimensional features. We describe a novel contextual chance-constrained programming formulation that incorporates features, and argue that solutions that do not take them into account may not be implementable. Our formulation cannot be solved exactly in most cases, and we propose a tractable and fully data-driven approximate model that relies on weighted sums of random variables. We obtain a stochastic lower bound for the optimal value and feasibility results that include convergence to the true feasible set as the number of data points increases, as well as the minimal number of data points needed to obtain a feasible solution with high probability. We illustrate our ﬁndings in a vaccine allocation problem and compare the results with a na¨ıve sample average approximation approach.
Metabolism and Chemical Degradation of New Antidiabetic Drugs (Part II): A Review of Analytical Approaches for Analysis of Gliptins

This paper is part II of the review on metabolism and chemical degradation of new antidiabetic drugs from glutides, gliflozins and gliptins. It is well known that metabolism data can be helpful for deriving safe levels of degradation impurities and their qualifying as far as toxicological aspects are concerned. As a result, it could link the quality of respective pharmaceutical products to clinical practice and patients. Some overlapping pathways of transformations of these important drugs of different chemical structures and different mechanisms of action were discussed. At the same time, the paper summarized interesting analytical tools for conducting modern drug metabolism as well as drug degradation experiments. The methods described here include liquid chromatography (LC) and liquid chromatography coupled with mass spectrometry (LC-MS or LC-MS/MS), which are widely used for detection and quantitative measurements of the drugs, their metabolites and degradants, as well as radiometric methods that are suitable for pharmacokinetic experiments. Special attention was paid to dedicated types of packing in chromatographic columns, as well as to special solutions in the LC-MS procedures. The present part addresses the analytical approaches elaborated for examining the metabolism and degradation pathways of gliptins that are dipeptidyl peptidase 4 (DPP-4) inhibitors.
Comparison of different technologies using organic acid and mineral acid solvents on pectin extraction from apple pomace

Pectin is one of the most widely used functional polysaccharide, which is extensively used in food, biotechnological, chemical, cosmetic, and pharmaceutical industries. Pectin can be suitably extracted from apple pomace which is the main by-product of apple juice industry. In this study, pectin obtained from microwave assisted extraction (MAE) and conventional extraction (CE) were compared in terms of extraction yield, extraction time and extraction temperature. The type of acids namely organic acids and mineral acids were also compared, in which pectin from apple pomace was extracted using different concentration of organic acid (citric acid, 0.1 M and 0.05 M) and mineral acid (hydrochloric acid, 0.1 M and 0.05 M). The best extraction condition of the extraction process was found to be higher in yield by using citric acid at microwave power of 180 W, solid-to-liquid ratio of (1:25), concentration of citric acid of 0.1 M for 90 s. Under these conditions, the extraction yield of pectin reached 19.1 ± 0.2%, methoxyl content (5.27%), anhydroglacturonic acid (43.38%) and degree of esterification (68.97%). The current work showed that critic acid is a ‘green’ and safe acidic solvent that could be used to extract pectin from apple pomace that was highly competitive and environmentally friendly process. The microwave Assisted extraction method is considered to be a potential alternative conventional (traditional) extraction method. The obtained data undertakes that apple pomace obtained by the green extraction has a great potential to be a valuable source of pectin, while preserving similar quality to conventional sources of pectin.
Psychological Interventions for Cannabis Use among Adolescents and Young Adults: A Systematic Review

Regular cannabis use during adolescence can lead to cognitive, psychological, and social consequences, causing significant distress. Although psychological interventions are the mainstay type of treatment for cannabis use disorder, the results remain mixed among youths. The objective of this review is twofold: to identify the existing psychological interventions for cannabis use among youths, and to assess the evidence regarding the effectiveness of those interventions. Randomized controlled trials focused exclusively on cannabis use among adolescents and young adults were included. Three databases—Embase, PsycInfo, and PubMed—were searched to identify relevant peer-reviewed manuscripts published before February 2022 in English and French. The risk of bias was assessed using the Cochrane Collaboration’s tool. Twenty-five randomized controlled trials were included. Fourteen studies reported a significant outcome related to cannabis use. These were mainly non-intensive, online interventions that aimed to improve the patients’ relationships and emotion regulation. This review highlights the need to conduct additional randomized control trials that target cannabis use disorder specifically among adolescents. These randomized control trials should also aim to reduce the risk of bias related to psychiatric comorbidities as well as detection and attrition problems.
The Potential Relationship Between Income Inequality and Environmental Quality in Iran: The Panel Quantile Regression Approach

This paper addresses the relationship between income inequality and environmental quality in the agriculture sector as the most related sector to the environment. In this context, we used a panel data set for 28 provinces of Iran during 2003-2017 and implemented panel quantile regression. To choose the best econometric specification the Taylor diagram is used. To explore whether the effect on income inequality on CO2 emission is different for rich and poor provinces, we consider the GINI × GDP interaction term in the model. Results confirmed that EKC in the agriculture sector of Iran, and a major and significant effect of energy consumption on CO2 emission. Findings indicated a threshold per capita income ($ 17.60 thousand) from which the effect of income inequality on carbon emissions changes. Based on these results, Marginal Properties to Emit (MPE) is more significant for poor people in low-income provinces than rich ones. Therefore, the government should adopt appropriate policies to increase the income of farmers so that the policy of income distribution, along with social justice, also improves the quality of the environment.
Analysis of the Types of Classroom Questions Which Jordanian English Language Teachers Ask

The present study aimed to explore the types of classroom questions which Jordanian English language teachers ask. The sample of the study consisted of 77 teachers who were randomly selected from different public and private schools in Amman- Jordan. A total of 1574 classroom questions were collected and analyzed using descriptive statistics, t test and analysis of variance. The results showed that 80% of teachers’ questions were on low thinking levels; 77% were closed-ended questions; and 86% were display questions. The results also indicated that teachers used higher thinking questions, more referential questions, and more open- ended questions at upper basic stage and secondary stage. It was recommended that EFL teachers in Jordan ask different types of questions at each grade level.
A Comparative Study of the Flap and Flapless Techniques of Ridge Preservation: A Clinical Double-Blinded Study

Introduction: Extraction of the tooth often leads to crestal bone loss. It is difficult for clinicians to decide on the technique of extraction. Many studies on flap and flapless have led to confusion. Hence it becomes necessary to conduct this study to show the efficient ridge preservation technique. Materials and Methods: Twenty patients were selected for this study. It was divided into the flap and flapless groups. In group A, the flap was elevated, tooth extraction was undertaken, the socket was cleaned, a graft was placed, a barrier was placed, and a suture was placed. In group B all the procedures were the same but without flap elevation. After surgery, clinical and radiographical parameters were recorded. Result: Flapless technique showed a better result in bone preservation. There was a low vertical bone loss in the flapless technique. Conclusion: Both techniques showed bone loss. But the flapless technique gave better results.
Reliability evaluation of Convolutional Neural Network’s basic operations on a RISC-V processor

—Thanks to RISC-V open-source Instruction Set Ar- chitecture, researchers and developers can efficiently propose new solutions at a low-cost and low-power consumption. RISC-V- based architectures can, then, be customized to run Machine Learning (ML) algorithms efficiently and be inserted on safety and mission-critical domains, where the execution must be reliable. However, a fault in the hardware resources can compromise the system’s ability to operate correctly. Thus, it is necessary to characterize the ML applications’ vulnerabilities on RISC- V processors, as it is not as thoroughly characterized as other accelerators. This work is the first to evaluate the neutron- induced error rate of Convolutional Neural Network (CNN) basic operations running on a RISC-V processor, GAP8. Our results show that executing the algorithm in parallel increases performance, and memory errors are the major contributors to the device error rate. We show that the error rate of the GAP8 unprotected memories is one order of magnitude higher than the CNN basic operations.
Evaluation of Hearing Performance in Patients with Oral Submucous Fibrosis in Relation to Different Grades

Background: OSMF is now recognized worldwide as an Indian disease. Blanching and rigidity of the oral mucosa, impaired mobility of the soft palate and tongue, difficulty opening the mouth, burning sensation, lack of gustatory sensation, and mild deafness due to Eustachian tube dysfunction. Soft palatal muscles often affect Eustachian tube function. Materials and Methods: Rama Dental College Hospital and research center Kanpur conducted a cross-sectional study. 60 OSMF patients were randomly selected for this study. Visible light was used for a detailed case history and clinical examination. OSMF was diagnosed by difficulty opening the mouth, blanched oral mucosa, and palpable fibrous bands. Burning, salivation, tongue protrusion, habits, and malignant changes were also diagnostic. ENT specialists used pure tone audiometry to examine the ear (PTA). Results: Out of 60 patients 59 were males and 1 female. The participants who took part in this study ranged in age from 18 to 65. Pure tone audiometry of 120 years, 84 (70%) revealed normal hearing, 10 (8.33%) revealed minimal hearing loss, 14 (11.67%) revealed mild hearing loss and 12 (10%) revealed moderate hearing loss. Conclusion: In order to improve the success rate of treatment, the protocol for managing OSMF patients should therefore include ENT consultation and hearing impairment treatment.
Evaluation of lauric acid and L-glutamate individually and in combination as pro-nutrient growth promoters in broiler chickens

This experimental study aimed to elucidate the effect of dietary supplementation of lauric acid and L-glutamic acid on the production performance and carcass characteristics of broilers. Day-old broiler chicks (160) were randomly divided into four groups. The chicks were fed with four experimental diets, such as control diet without antibiotics (T1), control + 0.1% lauric acid (T2), control + 0.5% glutamate (T3), and control + 0.1% lauric acid + 0.5% glutamate (T4). The experiment was performed for five weeks using standard management practices. The production performance and carcass characteristics were determined. The body weight, feed intake, and feed conversion efficiency showed significant improvement in the treatment group fed with 0.5% glutamate. The carcass attributes, such as pre-slaughter weight, de-bleeding weight, eviscerated carcass weight, giblet weight, and abdominal fat weight were comparable among the treatments. No significant difference among the groups on serum biochemical parameters was observed. Further, the intestinal length was significantly higher in the T3 group. It was concluded that supplementation of 0.5% glutamate as a pronutrient improved the production performance and increased intestinal length without affecting the other carcass characters in broiler chicken.
Discursive Textual Analysis & Iramuteq: Potentials of the Blended Process

Background: For years, scholars have been studying possibilities for science teaching. Science Clubs became an alternative since they are spaces around collective interests. Objectives: How is the discursive textual analysis method configured in a blended process, given its three analytical stages, supported by the IRaMuTeQ software? The objective was to present, in full, the discursive textual analysis method, supported by the IRaMuTeQ software, to understand the blended procedure that includes the analytical stages. Design: The research approach is qualitative. The global corpus is based on four dialogues about the universe of Science Clubs. Setting and participants: The participants are two researchers with extensive experience. The information analysed is four dialogues about Science Clubs. Data collection and analysis: There were five meetings lasting approximately 120 minutes each. The analysis method adopted is the discursive textual analysis, supported by the IRaMuTeQ software. In the software, the baseline analysis was descending hierarchical classification. Results: The emergence of five intermediate categories was identified, and it is possible to observe, as the main result, from the subcorpus analyses, the recognition of the composition of each intermediate category by other five to seven initial categories. Conclusions: The subcorpus analysis procedure is vital for understanding the constructions of each emerging intermediate category, configuring itself as an advanced level of understanding of categorisation. Thus, we concluded that the discursive textual analysis, with software support, is a blended analysis process.