Miracle-dz/UniFAR-FTUs huggingface dataset:
Diagnostic and therapeutic recommendations of the Polish Society of Haematologists and Transfusiologists and Polish Adult Leukemia Group-CLL for chronic lymphocytic leukemia in 2021

Chronic lymphocytic leukemia (CLL) is a disease of the elderly, with a median age at diagnosis of approximately 70 years. The natural course of the disease varies greatly, and patients with non-progressive and asymptomatic leukemia do not require treatment. The results of CLL treatment have improved significantly in recent years, mainly due to the introduction of new, more effective drugs, including BCR inhibitors and BCL2 inhibitors. The new drugs are used continuously, while venetoclax in combination with anti-CD20 antibodies is used for 24 (rituximab) or 12 (obinutuzumab) months, depending on the type of antibody and line of therapy. The choice of treatment protocol should largely depend on the assessment of 17p deletion/ TP53 mutation and immunoglobulin variable heavy chain (IGVH) mutation status, which correlate with a worse response to immunochemotherapy. The role of immunochemotherapy, which until recently was the mainstay of CLL treatment, has now significantly decreased. In the first-line, it is recommended only in patients without 17p deletion/ TP53 mutation, with mutated IGVH. Other patients should receive novel targeted therapies. However, at the time of the preparation of these recommendations, these therapies are not available in the firs-line of treatment in Poland. Novel targeted therapies play a major role in the treatment of refractory/relapsed CLL, and immunochemotherapy is recommended primarily in patients with a long-term response to first-line therapy. In this article, we present an update of the guidelines for the diagnosis and treatment of CLL, including the treatment of autoimmune complications, as well as the prophylaxis and treatment of infections, developed by the Polish Society of Haematologists and Transfusiologists and PALG-CLL Working Group.
On the adaptive lattice notch filter for the detection of sinusoids

A lattice notch filter for the detection and enchancement of sinusoids in noise is presented, and the convergence properties of the algorithm are investigated using ODE (ordinary differential equation) analysis. It is shown that the frequency estimate of the algorithm for a single sinusoid is unbiased, regardless of the pole-zero contraction factor and the noise variance. An expression for the MSE (mean square error) of the frequency estimate and the output SNR of the algorithm is derived. Simulation results are presented to verify the theoretical analysis. Based on cascading the proposed second-order adaptive notch filter, three different approaches for the detection of multiple sinusoids are presented. The first approach uses a linear cascade structure, and the second and third approaches use a triangular cascade structure. The performance of the algorithms for multiple sinusoids is investigated, and computer simulation results are presented and discussed. >
Soil Roughness Changes from Rainfall

ABSTRACT CHANGES in soil surface roughness were measured for three tillage systems following the application of a series of simulated rainstorms. Tillage systems were chisel, chisel + disking, and chisel + disking + harrowing. Rain with an intensity of 50 mm-h-i and an energy rate of 0.0275 kJ-m~2 per mm of water was applied in storms of 0.3, 0.5, 0.7, 1.5, 3.0 and 6 h durations. Soil surface roughness was expressed by a parameter R which represented the effect of clod size and frequency. Roughness changes could be described by the function R = Cj + C2 exp( —C3-r) where r is the cumulative rainfall. Autocorrelation analysis showed substantial variation in the spatial dependency of (a) the roughness parameter R among tillage systems and (b) the measured elevations on a transect following different rainstorm events.
Effect of Negative Parenting Dimensions on Adolescent’s Psychological Wellbeing: The Moderating Role of Age

Background. Adolescence psychological wellbeing is affected by several factors but the mostimportant are parenting practices perceived by them. The parenting practices in the form ofdimensions especially negative undermine their psychological wellbeing as a result they feel lesscompetent and this hinders the ideal ways to reach the level of optimal functioning. This study wascarried out to examine the effect of negative parenting dimensions on adolescents’ psychologicalwellbeing. It is hypothesized that negative parenting dimensions (poor monitoring, inconsistentdiscipline, and use of corporal punishment) negatively correlate with the adolescents’psychological wellbeing. The moderating role of age was also explored.Method. A sample of 400 adolescents aged 13-19 years (M = 15.98, SD = 1.90) comprising 50%boys and 50% girls approached from educational institutions of Islamabad and Rawalpindi, and thewilling participants completed the questionnaires. The study variables were measured by theAlabama Parenting Questionnaire (Frick, 1991) and the Ryff Scale of Psychological Wellbeing(Ansari, 2010). The convenient sampling technique was used to gather the data.Result. The results of the study showed that negative parenting dimensions have significantnegative relationship with the adolescents’ psychological wellbeing (r = -0.35, p < .001). Themoderation analysis revealed that there is a significant negative moderating role of age in therelationship of negative parenting dimensions and adolescent’s psychological wellbeing (β=.44**,p<.01, ΔR2 = 0.173). Conclusion. It is concluded that when individuals have a restrictive and controlled environment,it may hinder personal growth, individuals feel less competent and psychologically disturbed. Thefindings of the study can help educate the parents to use more productive and positive parentingpractices. It is recommended that different intervention strategies can be planned to educate theparent and adolescent and how they make a strong relationship among them.
Effective action recognition with fully supervised and self-supervised methods

Action recognition in videos has attracted interest in computer vision and machine learning communities thanks to its applications such as surveillance and smart homes. In addition to spatial information in individual frames, videos contain temporal information across the temporal dimension. Therefore, effective spatiotemporal representation is the key to accurate action recognition in videos. Previous works have proposed various fully-supervised and self-supervised methods for video representation learning. For fully-supervised methods, most of them utilize convolution neural networks (CNNs) to extract spatial representation while temporal representation is usually modelled by pixel-wise correlations. However, it is inefficient to extract correlations between all pixels since some of them may relate to in-salient area (e.g. backgrounds or environments). On the other hand, self-supervised methods are proposed to leverage more accessible unlabled data on the Internet and transfer the extracted representation for different downstream tasks. The core of self-supervised methods is to design a pretext task where supervision signal is automatically generated based on characteristics of unlabeled data. Although self-supervised methods avoid the annotation of labeled data, compared to fully-supervised methods, there is room for performance improvement of selfsupervised methods. In this thesis, we address the above research gap with two novel deep learning methods, to advance fully-supervised and self-supervised methods, respectively. For fully-supervised learning, we propose a novel Key Point Shift Embedding Module (KPSEM) to adaptively extract channel-wise key point shifts across video frames without key point annotation for temporal feature extraction. Key points are adaptively extracted as feature points with maximum feature values at split regions, while key point shifts are the spatial displacements of corresponding key points. The key point shifts are encoded as the overall temporal features via linear embedding layers in a multi-set manner.
Novelty and Technical Complexity: Critical Constructs in Capital Projects

AbstractOne of the challenges in project management research is that projects, by definition, are unique. However, the degree to which any project differs from another varies on the basis of a range of attributes. Two industrial facilities that vary by an order of magnitude in size may, in fact, be very similar and experience similar outcomes. However, two identical industrial facilities that are constructed by different contractors may experience vastly different outcomes. In the first case, the two buildings may have the same set of technical characteristics. In the second case, all else being equal, the different outcomes may be attributable to the contractors’ experience with the construction of this type of facility. This paper expands on these two cases and proposes that all projects can be partially defined in terms of two distinct attributes: technical complexity and novelty. The technical characteristics of a project define its technical complexity. The degree of the project participants’ experie.
The Use of Travel-Related WeChat Mini-Programs in China: An Affordance Theory Perspective

The travel-related applications on a smartphone help tourists make a reservation before their trip conveniently; use a map, direction guidance, and translation services during the travel; evaluate and recommend travel services communicating with others after their journey. This study examines the relationships among affordances and constraints provided by the mini-program, users’ perceived value, and travel-related mini-program (TRMP) usage by analyzing the structural equation modeling. An online questionnaire was developed from the available scales in the published literature. A total of 651 TRMP users responded to the survey, and 448 valid responses were included for analysis. Affordance, including physical, cognitive, sensory, and functional affordance, significantly influenced the hedonic value of TRMP; utilitarian value except for cognitive affordance. There were negative relationships between unfamiliarity and both types of value. The utilitarian and hedonic value of TRMP significantly influenced both the exploitative and explorative use of TRMP. Travel-related mobile applications are dramatically increased in the tourism field. This research sheds light on TRMP usage, as a new and smart device, from a user’s perspective based on the affordance theory. This study represents a valuable direction regarding the emerging travel-related online platforms in tourism.
Measurement of indoor radon, thoron and their progeny levels in dwellings of Union Territory Chandigarh, India: correlation with radon exhalation rates

Presence of radon, thoron and their decay products in household environment is considered a potential health hazard. Measurement of their levels is an important aspect to assess the threat they may pose to humans. Considering this their measurement from some dwellings of Union Territory Chandigarh, India has been carried out. Seasonal variation of these values has also been studied. A correlation study of exhalation rates from soil samples of areas close to the dwellings has also been carried out. The indoor radon concentration varied from 7.9 ± 0.5 to 39.2 ± 2.3 Bq m−3 with an average of 23.3 Bq m−3 while the thoron concentration in the same dwellings varied from 0.15 ± 0.01 to 24.6 ± 1.0 Bq m−3 with an average of 10.7 Bq m−3. Annual effective dose varied from 0.3 to 1.4 mSv with an average of 0.8 mSv. The radon mass and surface exhalation rates from the soil samples varied from 0.9 to 1.9 mBq/kg/h with an average of 1.39 ± 0.29 mBq/kg/h and 20.7–42.3 mBq/m2/h with an average of 31.4 ± 6.8 mBq/m2/h, respectively. The value of in situ gamma dose found to be varied from 0.14 to 0.31 µSv/h.
Rate of insecticide formulations on the damage assessment, yield and yield components of cowpea

main ridges) and spaced at 0.75 m apart. Each plot size was 26.25 m 2 (gross) and separated by a 1.5 m wide border margin on all sides. Four insecticide formulations: Chlorpyrifos 480 E. C. (Chlorpyrifos 480 g/L E.C), Chlorpyrifos plus (Chlorpyrifos 475 g/L+ Cypermethrin 47.5 g/L), Dimethoate 400 E. C. (Dimethoate 400g/L) Imidacloprid 70WG (Imidacloprid 70 WG.), (each applied at 1.5, 1.0 and 0.5 litre per hectare and 0.5, 1.0 and 1.5 kg/ ha for Imidacloprid), standard check (Cyperdicot) at 1.0 l/ha and an untreated control. All the treatments were replicated three times. The treatments were arranged in a randomized complete block design (RCBD). The damage was assessed by counting the number of aborted flowers/plot, seed damage indices (Sdi) was determined by sorting the seed lot from each plot into 3 categories. Pods harvested from each plot were placed in separate polythene bags, labeled and taken to the laboratory where the pod and seed weights were taken using an electric balance. Grain yield was recorded from threshed grains harvested from each plot. All data were analyzed using Analysis of Variance (ANOVA) with SAS package and treatment means separated by Duncan Multiple Range test at 5 % level of significance. The results showed that all the four insecticides effectively reduced the infestation of insect pests and increase yield compared to untreated control.
The Effect Of Sports Events On The Motivation And Interest Of Repeat Visit Tourists In The Lake Sipin Tourism Area, Jambi City

This study aimed to analyze the effect of organizing sporting events on revisit intention mediated by the tourist motivation in the tourism area of Danau Sipin, Jambi City. The population in this study were tourists who visited the tourist area of Danau Sipin, Jambi City. The sample in this study was selected by accidental sampling method. This method was chosen because it was difficult to determine the visitor data for tourist attractions because it changes every day, so the samples were the visitor that the researcher met randomly in the tourist area of Danau Sipin, Jambi City. Data analysis in this study used the Partial Least Square (PLS) approach with the help of the WarpPLS 7.0 software. The results of this study indicated that organizing sporting events had a direct effect on motivation and revisit intention. The results of this study also indicated that the sporting events had an indirect effect on revisit intention which was mediated by tourist motivation
Boundary equation from a lattice model and modification of the Peierls equation

ABSTRACT The boundary equation establishes the relationship between the displacement and the external force on the boundary of a solid. In the short-range interaction approximation, the boundary equation of a half-infinite lattice can be formally derived in lattice statics. Based on a model of cubic lattice, the boundary matrix as the kernal of the boundary equation is studied and calculated. In particular, the boundary matrix is completely presented for quasi one-dimensional problem and the leading order correction to the results in the elastic continuum theory is explicitly determined. The boundary equation can be used to derive the dislocation equation as a generalisation of classical Peierls equation. As an application, the modification of the Peierls equation is obtained and relevant coefficients are successfully related to bulk properties of solids.
Numerical Study of the Bearing Behavior of Piled Rafts

Based on a numerical study by means of three-dimensional finite-element analysis, this paper discusses investigations of the bearing behavior of piled rafts in overconsolidated clay. It is shown that the interaction between piles and rafts is a major influence. The potential savings of an optimized foundation design are demonstrated for a simple example.
The development of a conceptual model regarding the role of social modelling in safety behaviour: an integrated literature review

Social modelling is a process where an individual observes a model's behaviour and its consequences, leading to a modification of the observer's old behaviours or the acquisition of new behaviours. Even though diverse fields, including transportation and aviation, have reliably found significant results pertaining to the influences of social modelling on behavioural outcomes, there is a lack of research pertaining to social modelling's influences specifically on safety behaviour. This review details the safety issues related to the mechanisms, influences and effects of social modelling as a way to examine the potential that social modelling has in affecting employees’ safety behaviour. The collected research materials aided in the construction of a preliminary conceptual model regarding the effects of social modelling on safety behaviour. Overall, the review provides safety and organisational researchers with information about a gap in the safety literature and a model that can lead to future research to fill that gap.
Predicting Pilot Task Demand Load During Final Approach

This research aims at developing a method to assess the safety of airport approaches from the perspective of airline pilots. The main hypothesis is that safety is inversely proportional to the task demand load (TDL) experienced by the pilots conducting it. The TDL is the mental workload imposed by the system to be controlled, and is not to be mistaken for the mental workload experienced by the operator, referred to as mental load. This article presents the results of preliminary research that focused on how some of the environmental factors that determine the approach, such as the type of aircraft and the meteorological conditions, affect the TDL. A paper pilot model, consisting of a scanning model, mental model, and control model, was used to quantify how hard an average pilot has to work to conduct the specified approach. Offline computer simulations with this model revealed some clear trends in pilot scanning rate, task error, and control activity, as a function of the environmental factors, which will eventually allow for a prediction and quantification of the TDL. Depending on the approach performance requirements on the one hand, and the pilot scanning capacity on the other, increasing turbulence intensity showed a change in trend for all TDL-related parameters at a particular turbulence intensity. Results from a pilot-in-the-loop evaluation, conducted in a fixed-base flight simulator, supported the main trends of the offline simulation trials. They also indicated that through adopting different scanning strategies, pilots can leverage their workload; more research is necessary to clarify this result, however.
GaAs single-barrier varactors for millimeter-wave triplers: guidelines for enhanced performance

Earlier single-barrier varactors (SBVs) fabricated on GaAs suffered from low Q because of leaky barriers. By placing a thin AlAs layer in the center of an Al/sub 0.4/Ga/sub 0.6/As barrier, and using In/sub 0.2/Ga/sub 0.8/As spacers, one can increase the effective barrier height, thereby achieving SBVs with both high Q and good capacitance-modulation characteristics. Simulation of a 192-GHz tripler using these varactors shows purely reactive multiplication, without the output-power saturation both predicted and observed in triplers using leaky-barrier SBVs. >
Guaranteed conditional performance of the S2 control chart with estimated parameters

We evaluate the in-control performance of the S2 control chart with estimated parameters conditional on the Phase I sample. Simulation results indicate no realistic amount of Phase I data is enough to have confidence that the in-control average run length (ARL) obtained will be near the desired value. To overcome this problem, we adjust the S2 chart’s control limits such that the in-control ARL is guaranteed to be above a specified value with a certain specified probability. The required adjustment does not have too much of an adverse effect on the out-of-control performance of the chart.
Highly Linear Tunable CMOS - Low-Pass Filter

A comprehensive analysis of tunable transconductor topologies based on passive resistors is presented. Based on this analysis, a new CMOS transconductor is designed, which features high linearity, simplicity, and robustness against geometric and parametric mismatches. A novel tuning technique using just a MOS transistor in the triode region allows the adjustment of the transconductance in a wide range without affecting the voltage-to-current conversion core. Measurement results of the transconductor fabricated in a 0.5- m CMOS technology confirm the high linearity predicted. As an application, a third-order Gm-C tunable low-pass filter fabricated in the same technology is presented. The measured third-order intermodulation distortion of the filter for a single 5-V supply and a 2-V two-tone input signal centered at 10 MHz is 78 dB. Index Terms—Analog CMOS circuits, continuous-time filters, Gm-Cfilters,harmonicdistortion,transconductors,tunablefilters.
Thermal effusivity measurement of virgin coconut oil-methanol mixtures using photoacoustic technique

Thermal effusivity of virgin coconut oil-methanol mixtures were measured using open photoacoustic cell technique. The samples were prepared by simply mixing virgin coconut oil and methanol using similar procedure applied for preparation of biodisel. Thermal effusivity of the sample was obtained by fitting the experimental data of photoacoustic amplitude signal to the expression of photoacoustic signal as a function of chopping frequency. Thermal effusivity of mixtures decrease between 0.0851 W s1/2 Kâ1 cmâ2 (pure virgin coconut oil) and 0.0644 W s1/2 Kâ1 cmâ2 (pure methanol) with the increasing of methanol in the mixture.
Understanding the role of individual learner in adaptive and personalized e-learning system

Dynamic learning environment has emerged as a powerful platform in a modern e-learning system. The learning situation that constantly changing has forced the learning platform to adapt and personalize its learning resources for students. Evidence suggested that adaptation and personalization of e-learning systems (APLS) can be achieved by utilizing learner modeling, domain modeling, and instructional modeling. In the literature of APLS, questions have been raised about the role of individual characteristics that are relevant for adaptation. With several options, a new problem has been raised where the attributes of students in APLS often overlap and are not related between studies. Therefore, this study proposed a list of learner model attributes in dynamic learning to support adaptation and personalization. The study was conducted by exploring concepts from the literature selected based on the best criteria. Then, we described the results of important concepts in student modeling and provided definitions and examples of data values that researchers have used. Besides, we also discussed the implementation of the selected learner model in providing adaptation in dynamic learning.
Product lifecycle management: the new paradigm for enterprises

Product Lifecycle Management (PLM) is a developing paradigm. One way to develop an understanding of PLM's characteristic and boundaries is to propose models that help us conceptualise both holistic and component views in compact packages. Models can give us both a rich way of thinking about overall concepts and can identify areas where we need to explore issues that such models raise. In this paper, the author proposes and discusses two such related models, the Product Lifecycle Management Model (PLM Model) and the Mirrored Spaces Model (MSM) and investigates the conceptual and technical issues raised by these models.