Miracle-dz/UniFAR-FTUs huggingface dataset:
EFFECTIVENESS OF THE MANNHEIM INDEX IN PREDICTING MORBIDITY AND MORTALITY OF PATIENTS WITH PERFORATIVE PERITONITIS

Background: Peritonitis is an inflammation of the peritoneal cavity caused by various pathogens and is associated with a high morbidity and death rate. The study aims to predict the prognosis of patients with perforation peritonitis and assess the impact of the MPI score in identifying high-risk cases. Materials and Methods: This prospective observational study was conducted at Tirunelveli Medical College and Hospital from September 2019 to August 2021. One hundred fifty patients with peritonitis due to hollow viscous perforation were included in the study. Informed consent was obtained from all patients, and ethical approval was obtained before the study started. Diagnosis of peritonitis due to hollow viscous perforation was made by history and clinical examination, and standard operative procedures were followed. Mortality and morbidity were assessed for post-operative complications. Result: Most patients were male, with 122 (81.3%) and 28 (18.7%) female. The most common age group was > 61 years 36 (24%). Most of the patients were observed with Duodenal perforations 78 (52%), gastric 32 (21.3%), and Ileal perforation 20 (13.3%). Patients with MPI values between 21 and 29 were the most common. 24 (16%) having ARDS complications, 140 (93.3%) secreting cloudy exudates, and 9 (6%) mortality. MPI score is associated with morbidity, post-operative complications, and mortality in patients with ARDS post-operative complications. Only cloudy exudates were observed with mortal patients 9 (6.4%). Conclusion: Mannheim Peritonitis Index is useful for assessing adverse outcomes in patients with peritonitis.
A COMPARATIVE STUDY OF AUDITORY BRAIN STEM EVOKED RESPONSE IN HYPOTHYROID PATIENTS AND HEALTHY INDIVIDUALS

Background: Thyroid hormone enhances wakefulness, response to various stimuli like auditory sensation, learning and memory capacity. By enhancing gene expression, it influences the synthesis of myelin. The purpose of the study is to assess the auditory pathway with the help of auditory brainstem response (ABR) for risk assessment in hypothyroid patients so as to promote early detection and possible prevention of hearing impairment. Materials & Methods: This is a cross sectional study done on 100 subjects of 20 - 50 years in the Research laboratory of Department of Physiology, S.M. S Medical College, Jaipur during period extended from May 2021 to December 2022. The BAER was recorded by using RMS EMG 2000 system with installed BAER software. Two or three trials were performed in order to demonstrate the consistency of the wave form. The absolute latencies of all BAER waves and their IPL of I-III, III-V and I-V were marked with the help of digital cursors and the values were noted down. Results: The mean age was 38.32 years for newly diagnosed hypothyroid cases and 35.82 years for normal healthy controls. There was no significant difference between the groups, so they were comparable. The mean Body Mass Index of Group A was 24.9 kg and Group B was 22.8 kg. The hypothyroid patients had higher BMI than control group. There were not statistically significant interaural differences of absolute latencies and interpeak latencies in newly diagnosed hypothyroid patients. There was a positive correlation between serum TSH and the BAER parameters and a negative correlation was found with serum free T3, free T4. Conclusion: We found a significant prolongation of absolute latencies and inter peak latencies of brainstem auditory evoked responses in newly diagnosed hypothyroid individuals even before the hearing loss overt.
POLITECNICO DI TORINO Repository ISTITUZIONALE

—Understanding the behavior of a network from a large scale trafﬁc dataset is a challenging problem. Big data frameworks offer scalable algorithms to extract information from raw data, but often require a sophisticated ﬁne-tuning and a detailed knowledge of machine learning algorithms. To stream-line this process, we propose SeLINA ( S elf-L earning I nsightful N etwork A nalyzer), a self-tuning tool to extract knowledge from network trafﬁc measurements. SeLINA includes different data analytics techniques providing self-learning capabilities to state-of-the-art scalable approaches, jointly with parameter auto-selection to off-load the network expert from tuning. We combine both unsupervised and supervised approaches to mine data with a scalable approach. SeLINA embeds mechanisms to check if the new data ﬁts the model, to detect possible changes in the trafﬁc, and to, possibly automatically, trigger model rebuilding. The result is a system that offers human-readable models of the data with minimal user intervention, supporting domain experts in extracting actionable knowledge and highlighting possibly meaningful interpretations. SeLINA’s current implementation runs on Apache Spark. We tested it on large collections of real-world passive network measurements from a nationwide ISP, investigating YouTube and P2P trafﬁc. The experimental results conﬁrmed the ability of SeLINA to provide insights and detect changes in the data that suggest further analyses.
DrivenShape: a data-driven approach for shape deformation

At runtime, we have a new pose Pnew and wish to reconstruct corresponding deformationDnew . We express the new target shape Dnew as weighted sum of Di in the database, Dnew = ∑ wi ∗Di , and usePnew to compute weights such that Pnew = ∑ wi ∗Pi. In a mathematical form, we wish to minimize ‖ A ∗ w − b ‖, where A’s column vectors are filled with vertices of Pi, w is the weights, andb is a column vector with vertices of Pnew .
Review: Cholinergic mechanisms and epileptogenesis. The seizures induced by pilocarpine: A novel experimental model of intractable epilepsy

High‐dose treatment with pilocarpine hydrochloride, a cholinergic muscarinic agonist, induces seizures in rodents following systemic or intracerebral administration. Pilocarpine seizures are characterized by a sequential development of behavioral patterns and electrographic activity. Hypoactivity, tremor, scratching, head bobbing, and myoclonic movements of the limbs progress to recurrent myoclonic convulsions with rearing, salivation, and falling, and status epilepticus. The sustained convulsions induced by pilocarpine are followed by widespread damage to the forebrain. The amygdala, thalamus, olfactory cortex, hippocampus, neocortex, and substantia nigra are the most sensitive regions to epilepsy‐related damage following convulsions produced by pilocarpine. Spontaneous seizures are observed in the long‐term period following the administration of convulsant doses of pilocarpine.
Multicategory Support Vector Machines

The Support Vector Machine (SVM) has shown great performance in practice as a classiﬁcation methodology. Oftentimes multicategory problems have been treated as a series of binary problems in the SVM paradigm. Even though the SVM implements the optimal classiﬁcation rule asymptotically in the binary case, solutions to a series of binary problems may not be optimal for the original multicategory problem. We propose multicategory SVMs, which extend the binary SVM to the multicategory case, and encompass the binary SVM as a special case. The multicategory SVM implements the optimal clas-siﬁcation rule as the sample size gets large, overcoming the suboptimality of the conventional one-versus-rest approach. The proposed method deals with the equal misclassiﬁcation cost and the unequal cost case in uniﬁed way.
A PROSPECTIVE STUDY ON EVALUATION OF ENDOMETRIUM IN ABNORMAL UTERINE BLEEDING

Background: Abnormal uterine bleeding is a very common gynecological problem and one of the most common debilitating menstrual problems affecting all age group of women. AUB negatively affect patient quality of life and is associated with financial loss, decreased productivity and poor health. The cause of AUB is age related pathology. This study was done to evaluate the histopathology of endometrium for identifying endometrial causes of AUB & their incidence in different age group. Materials and Methods: This study was done in the department of Pathology, BRD medical college, Gorakhpur over a period of two year. Total 212 samples were enrolled and analyzed in the study, 90 endometrial specimens obtained for examination were from the dilation and curettage and rest 122 samples were obtained from hysterectomy. Result: Histopathology examination of endometrial samples of AUB shows variable changes ranging from normal cyclic endometrium to malignancy. The various pathological patterns observed in endometrial samples are proliferative, secretory, menstrual, atrophic, disordered proliferative endometrium, endometritis, polyps, hyperplasia with or without atypia and endometrial malignancies. Conclusion: Histological assessment of endometrial samples remain the gold standard for clinical diagnosis of endometrial pathology in all women presenting with AUB, specially in women over 40years for the early detection of precancerous & cancerous endometrial lesion. Thus, endometrial sample is a valuable tool to indentify benign and
Comparative Evaluation of Conventional Versus Endoscopic Septoplasty for Deviated Nasal Septum

Objectives: To evaluate the advantages and disadvantages along with comparison of results of endoscopic septoplasty over conventional septoplasty. Methods: The prospective type of study was conducted in a tertiary referral centre and a total of 60 patients between the ages group of 18-35 years having symptomatic deviated nasal septum and refractory to conservative medical treatment were included in the study while patients with uncontrolled hypertension or diabetes, having upper respiratory tract infection or allergic rhinitis were excluded from the study. Patients were divided into two groups: Group A-consisted of 30 patients, in whom conventional septoplasty was done and Group B-consisted of 30 patients, in whom endoscopic septoplasty was performed. Post-operative assessment was carried out at 48hrs, 15days, 1 month and 3 months after the surgery. Results: 24 (80%) patients of Group A had improvement in nasal obstruction, 18 (90%) showed symptomatic relief from nasal discharge and headache was relieved in 17 (85%) patients. In Group B, 27 (90%) patients had improvement in nasal obstruction, 20 (90.9%) showed relief from nasal discharge and headache was relieved in 20 (95.2%) patients. Residual septal deviation was seen only in 3 (10%) patient of Group A. 3 (10%) cases developed synechiae in Group A as compared to 1 (3.3%) case in Group B. Lip oedema developed only in 3 (10%) of cases in Group A. Bleeding from nose requiring repacking was seen in 3 (10%) patients of Group A and 1 (3.3%) in Group B. Conclusion: Endoscopic septoplasty showed better results as compared to conventional septoplasty as endoscope gives better illumination and improved access to deviated nasal septum and allows limited incision, limited flap elevation, and achieves correction with least resection and thus reducing the post-operative complications.
Bounty and benevolence : a history of Saskatchewan treaties

The recent Supreme Court of Canada decision in Regina v. Marshall regarding the treaty rights of the Mi'kmaq dramatically underscored our need to understand the history of treaty relationships between Canada's First Nations and the Crown. The numbered treaties covering Canada's prairie provinces represent the culmination of the country's pre-modern treaty-making era, which ended in the early twentieth century. Sizable portions of the territories covered by six of these accords are located within the boundaries of Saskatchewan. "Bounty and Benevolence" offers a unique perspective and examination of the history of treaty making in this province. Frank Tough, Jim Miller, and Arthur Ray draw on a wide range of documentary sources to provide a rich and complex interpretation of the process that led to these historic agreements. The authors explain how Saskatchewan treaties were shaped by long-standing First Nations-Hudson's Bay Company diplomatic and economic understandings, treaty practices developed in eastern Canada before the 1870s, and the changing economic and political realities of western Canada during the nineteenth and early twentieth centuries. Tough, Miller, and Ray also show why these same forces were responsible for creating some of the misunderstandings and disputes that subsequently arose between the First Nations and government officials regarding the interpretation and implementation of the accords. "Bounty and Benevolence" offers new insights into this crucial dimension of Canadian history, making it of interest to the general reader as well as specialists in the field of First Nations history.
Determination of some dominant parameters of the global dynamic sea surface topography from GEOS-3 altimetry

The 1977 altimetry data bank is analyzed for the geometrical shape of the sea surface expressed as surface spherical harmonics after referral to the higher reference model defined by GEM 9. The resulting determination is expressed as quasi-stationary dynamic SST. Solutions are obtained from different sets of long arcs in the GEOS-3 altimeter data bank as well as from sub-sets related to the September 1975 and March 1976 equinoxes assembled with a view to minimizing seasonal effects. The results are compared with equivalent parameters obtained from the hydrostatic analysis of sporadic temperature, pressure and salinity measurements of the oceans and the known major steady state current systems with comparable wavelengths. The most clearly defined parameter (the zonal harmonic of degree 2) is obtained with an uncertainty of + or - 6 cm. The preferred numerical value is smaller than the oceanographic value due to the effect of the correction for the permanent earth tide. Similar precision is achieved for the zonal harmonic of degree 3. The precision obtained for the fourth degree zonal harmonic reflects more closely the accuracy expected from the level of noise in the orbital solutions.
Edinburgh Research Explorer Personality, Health, and Brain Integrity

Objective: To explore associations between the five factor model (FFM; Neuroticism, Extraversion, Openness/Intellect, Agreeableness and Conscientiousness) personality traits and measures of whole brain integrity in a large sample of older people, and to test whether these associations are mediated by health-related behaviours. Method: Participants from the Lothian Birth Cohort 1936 completed the International Personality Item Pool measure of the FFM and underwent a structural MR brain scan at mean age 73 years yielding three measures of whole-brain integrity: average white matter fractional anisotropy (FA), brain tissue loss, and white matter hyperintensities (N=529 to 565). Correlational and mediation analyses were used to test the potential mediating effects of health-related behaviours on the associations between personality and integrity. Results: Lower conscientiousness was consistently associated with brain tissue loss ( β =-0.11, p< 0.01), lower FA ( β =0.16, p< 0.001) and white matter hyperintensities ( β =-0.10, p< 0.05). Smoking, alcohol consumption, diet, physical activity, body mass index and a composite health behaviour variable displayed significant associations with measures of brain integrity (range of r =0.10 to 0.25). The direct effects of conscientiousness on brain integrity were mediated to some degree by health behaviours, with the proportions of explained direct effects ranging from 0.1% to 13.7%. Conclusions: The personality trait conscientiousness was associated with all three measures of brain integrity, which we tentatively interpret as the effects of personality on brain ageing. Small proportions of the direct effects were mediated by individual health behaviours. Results provide initial indications that life-time stable personality traits may influence brain health in later life through health promoting behaviours.
VARICOCELE IN MALE INFERTILITY COMPARISON OF DOPPLER AND CLINICAL PARAMETERS

Background: Varicocele is a common condition that affects 15-20% of men, leading to pain, discomfort, and infertility. The study aims to assess the relationship between Doppler and clinical parameters of varicocele, establish the reliability of Doppler sonography in diagnosing varicocele, and to compare Doppler grading with pre-and postoperative semen parameters. Materials and Methods: This prospective study was conducted at Dhanalakshmi Srinivasan Medical College and Hospital, Preambalur, from Feburary 2022 to Feburary 2023. Fifty male patients with primary infertility were enrolled in our study, and informed consent was obtained from all patients. Patients underwent clinical examination and sonography for varicocele, and semen analysis was performed to assess sperm count, motility, and morphology. Doppler reflux grading was used to compare pre-and postoperative semen parameters. Results: Most out of 50 patients had bilateral varicocele. Doppler Grading showed that most cases belonged to Grade II on the left side and Grade I on the right side. Doppler demonstrated reflux in all 10 cases (100%), clinically diagnosed as not having varicocle. The mean venous diameter was (0.21) on the right and (0.25) on the left and showed statistically significant relationship with clinical and Doppler grading. Statistically significant relationship exits between Doppler grading and sperm concentration in pre-operative semen analysis. There was improvement of 7.04 million in mean sperm concentration and 4.93% in mean sperm motility after the surgery. Conclusion: Doppler ultrasonography is reliable for diagnosing varicocele. Doppler grading shows statistically significant relationalship with venous diameter and preoperative sperm concentration.
ASSOCIATION OF DIFFERENT INFLAMMATORY MARKERS LIKE INTERLEUKIN-6, C-REACTIVE PROTEIN, PROCALCITONIN IN NEONATES SUFFERING FROM SEPSIS WITH SPECIAL REFERENCE TO COMPLEMENT COMPONENT C3 AND C4

Objective: To find out if c3-c4 hypocomplementemia is present and to observe weather interleukin-6(IL-6), C-reactive protein(CRP), and procalcitonin are associated to these complement components in the cases of neonatal sepsis. Materials and Methods: It was Institutional Observational Cross-sectional study conducted in the department of Biochemistry, and Sick new born care unit (S.N.C.U), Dept of Paediatric Medicine, at Medical College & Hospital, Kolkata,
NET Institute*

Alibaba’s Taobao is China’s dominant C2C e-commerce platform. Relying on novel transaction level data from its electronics category, this paper examines the roles of distance as well as seller and buyer experience in Chinese e-commerce. Our estimate of a gravity model shows that the distance elasticity in our data is greater than US C2C e-commerce but smaller than that of South America. In addition, we document greater home bias in China than either of the US or South American Settings. Moreover, by estimating a ‘new-new’ trade model using seller-level transaction data, this paper studies the link between seller experience and distance. Our results show that more experienced sellers tend to sell more and export their goods farther into the marketplace. ∗We are grateful for the comments from the conference participants at 2015 China India Insights Conference. We thank the NET Institute (www.NETinst.org) for financial support. Any comments are welcome. †Economics and Management School, Wuhan University, Luojia Hill, Wuhan, China, 430072. Email: liang.chen@whu.edu. cn ‡Simon Business School, University of Rochester, 3-206 Carol Simon Hall, Box 270100, Rochester, NY 14627. Email: Garrett.Johnson@Simon.Rochester. edu §Department of Economics, University of Toronto, Max Gluskin House 322, 150 St. George Street, Toronto. Email: yao.luo@utoronto.ca 1
Acute stress disorder and posttraumatic stress disorder in children and adolescents involved in assaults or motor vehicle accidents.

OBJECTIVE The authors investigated acute stress disorder and later posttraumatic stress disorder (PTSD) in children and adolescents who had been involved in assaults or motor vehicle accidents. METHOD They interviewed 93 patients 10-16 years old who were seen in an emergency department for having been assaulted or involved in a motor vehicle accident within 4 weeks after the assault or accident to assess acute stress disorder. At 6 months, they reinterviewed 64 (68.8%) of the patients to assess PTSD. RESULTS At initial interview, 18 (19.4%) of the 93 patients had acute stress disorder and 23 (24.7%) met all acute stress disorder criteria except dissociation. At 6 months, eight of the 64 patients (12.5%) had PTSD. Acute stress disorder and PTSD did not differ in prevalence between patients who had been assaulted and those who had been in accidents. Sensitivity and specificity statistics and regression modeling revealed that the diagnosis of acute stress disorder was a good predictor of later PTSD but that dissociation did not play a significant role. CONCLUSIONS Acute stress disorder has merit as a predictor of later PTSD in children and adolescents, but dissociation has questionable utility.
Machine learning uncovers blood test patterns subphenotypes at hospital admission discerning increased 30-day ICU mortality rates in COVID-19 elderly patients

Background Elderly patients with COVID-19 are among the most numerous populations being admitted in the ICU due to its high mortality rate and high comorbidity incidence. An early severity risk stratification at hospital admission could help optimize ICU usage towards those more vulnerable and critically ill patients. Methods Of 503 Spanish patients aged>64 years admitted in the ICU between 26 Feb and 02 Nov 2020 in two Spanish hospitals, we included 193 quality-controlled patients. The subphenotyping combined PCA and t-SNE dimensionality reduction methods to maximize non-linear correlation and reduce noise among age and full blood count tests (FBC) at hospital admission, followed by hierarchical clustering. Findings We identified five subphenotypes (Eld-ICU-COV19 clusters) with heterogeneous FBC patterns associated to significantly disparate 30-day ICU mortality rates ranging from 2% in a healthy cluster to 44% in a severe cluster, along three moderate clusters. Interpretations To our knowledge, this is the first study using age and FBC at hospital admission to early stratify the risk of death in ICU at 30 days in elderly patients. Our results provide guidance to comprehend the phenotypic classification and disparate severity patterns among elderly ICU patients with COVID-19, based only on age and FBC, that have the potential to establish target groups for early risk stratification or early triage systems to provide personalized treatments or aid the decision-making during resource allocation process for each target Eld-ICU-COV19 cluster, especially in those circumstances with resource scarcity problem.