Miracle-dz/UniFAR-FTUs huggingface dataset:
The Effects of Intrusion of Anterior Teeth by Skeletal Anchorage in Deep Bite Patients; A Systematic Review and Meta-Analysis

Background: Deep bite is known as one of the most common malocclusions, and its treatment and retention are often challenging. The use of mini-screws has been suggested as an ideal method for the intrusion of incisors in deep-bite patients. Still, there are conflicting reports regarding the superiority of this method compared to other common treatments. Aim: The aim of this systematic review and meta-analysis was to evaluate the effects of the intrusion of anterior teeth by skeletal anchorage in deep bite patients. Methods: From the beginning to 15 September 2022, articles on the topic of interest were searched in electronic databases including PubMed, Web of Science, Scopus, EMBASE, and Cochrane’s CENTRAL. Additionally, a hand search for pertinent studies and a search of the grey literature were carried out. After the selection of eligible studies, data extraction was performed using piloted forms. Inverse-variance random-effects meta-analyses were used to combine the outcome measures of dental indices, skeletal cephalometric indices, and dental cephalometric indices. Results: A total of 15 studies (6 RCT; 9 CCT) were included in the systematic review and 14 were used in the meta-analyses. The differences in overbite changes (MD = −0.45, p = 0.04), true incisor intrusion [u1-pp] (MD = −0.62, p = 0.003) and molar extrusion [u6-pp] (MD = −0.40, p = 0.01) were statistically significant and TADs showed better treatment results than other intrusion methods (segmented intrusion arch, utility arch, J hook headgear). No significant differences regarding overjet, molar and incisor tipping, and skeletal indices between mini-screw and other intrusion methods could be found. Conclusion: The use of mini-screws leads to lower overbite and higher true intrusion (about 0.45 and 0.62 mm, respectively) compared to the use of other methods for intruding upper incisors. Furthermore, the effect of TAD on extrusion of molar teeth is less (by 0.4 mm) than other methods.
Bile Acids and Biliary Fibrosis

Biliary fibrosis is the driving pathological process in cholangiopathies such as primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC). Cholangiopathies are also associated with cholestasis, which is the retention of biliary components, including bile acids, in the liver and blood. Cholestasis may worsen with biliary fibrosis. Furthermore, bile acid levels, composition and homeostasis are dysregulated in PBC and PSC. In fact, mounting data from animal models and human cholangiopathies suggest that bile acids play a crucial role in the pathogenesis and progression of biliary fibrosis. The identification of bile acid receptors has advanced our understanding of various signaling pathways involved in regulating cholangiocyte functions and the potential impact on biliary fibrosis. We will also briefly review recent findings linking these receptors with epigenetic regulatory mechanisms. Further detailed understanding of bile acid signaling in the pathogenesis of biliary fibrosis will uncover additional therapeutic avenues for cholangiopathies.
Adaptive H∞ Anti-Synchronization for Time-Delayed Chaotic Neural Networks

In this paper, an adaptive H∞ control scheme is developed to study the antisynchronization behavior of time-delayed chaotic neural networks with unknown parameters. This adaptive H∞ anti-synchronization controller is designed based on LyapunovKrasovskii theory and an analytic expression of the controller with its adaptive laws of parameters is shown. The proposed synchronization method guarantees the asymptotical anti-synchronization of drive and response systems. Furthermore, this method reduces the effect of external disturbance to an H∞ norm constraint. The proposed controller can be obtained by solving a linear matrix inequality (LMI) problem. An illustrative example is given to demonstrate the effectiveness of the proposed method. Subject Index: 044, 055
Difference of anterior and posterior orbital development in patients with congenital microphthalmia: a retrospective cohort study from China.

AIM To evaluate volume differences between anterior and posterior orbit and demographic characteristics of Chinese patients with congenital microphthalmia. METHODS A retrospective cohort study, involving 169 unilateral congenital microphthalmia patients aged between 1 and 57 years old was conducted. Three-dimensional images of the orbit were generated from past CT scans, and digital orbital volume comprehensive measurement was done. The measured data included orbital volume (OBV), posterior orbital volume (POV), orbital width (OBW), orbital height (OBH), orbital depth (OBD), and posterior orbital area ratio. RESULTS Significant differences were observed among OBV, POV, OBW, OBH, and OBD of the affected and unaffected eyes in different age-based groups (all P<0.001). Among them, OBH had the greatest different. The mean microphthalmic to contralateral ratio (MCR) of OBV, POV, OBW, and OBH continuously increased from 1 to 3 years old, whereas the MCR of POV decreased from 3 to 17 years old. The MCR of OBD was not found to be correlated to age. There was no significant difference between OBV, POV, OBW, and OBH in ages from 13 years old to adulthood (all P>0.05). The difference in posterior orbital area ratio between the affected and unaffected groups was not statistically significant (P>0.05). CONCLUSION OBH is maximally affected, whereas OBD is minimally affected by microphthalmia. Posterior orbital retardation began 2y prior to orbital retardation and occurred at 3 years old in the affected eye, suggesting that intervention therapy should be done before the age of 4.
Fermentation Quality, In Vitro Digestibility, and Aerobic Stability of Ensiling Spent Mushroom Substrate with Microbial Additives

Simple Summary In animal husbandry, spent mushroom substrate has not been effectively utilized as an agricultural byproduct. Ensiling is an important roughage processing method that can not only improve the palatability of feed but also prolong the storage time of high-water feed. At present, due to the different physicochemical properties of various agricultural byproducts, a unified conclusion on the effects of using microbial additives in agricultural byproducts has not been reached. Therefore, this experiment investigated the effects of lactic acid bacteria and cellulase on the fermentation quality, in vitro digestibility, and aerobic stability of Flammulina velutipes spent mushroom substrate silage (F-silage) and Pleurotus eryngii spent mushroom substrate silage (P-silage). It was found that the combination of application of lactic acid bacteria and cellulase is an effective strategy for improving the fermentation quality and aerobic stability of F-silage and P-silage. In addition, cellulase can be used as an additive to improve the in vitro digestibility of P-silage. Our research results provide technical support for a thorough understanding of the effects of microbial additives on spent mushroom substrate silage and provide a theoretical basis for the production of high-quality spent mushroom substrate fermented feed. Abstract This experiment investigated the effects of lactic acid bacteria and cellulase on the fermentation quality, in vitro digestibility, and aerobic stability of Flammulina velutipes spent mushroom substrate silage (F-silage) and Pleurotus eryngii spent mushroom substrate silage (P-silage). Silage treatments included groups without any additives (control), with lactic acid bacteria (L), with cellulase (E), and with lactic acid bacteria and cellulase (M). Data analysis was performed using independent sample t-test and analysis of variance. After 45 days of ensiling, the pH in F-silage and P-silage from the L, E, and M groups were lower than those in the control group (p < 0.05). The pH, acetic acid (AA), and propionic acid (PA) levels in P-silage were lower than those in F-silage, and the LA content in P-silage was higher than that in F-silage (p < 0.05). Compared with the control, the E treatment increased in vitro neutral detergent fibre digestibility (IVNDFD) and in vitro acid detergent fibre digestibility (IVADFD) in F-silage and P-silage (p < 0.05). The aerobic stability of F-silage inoculated with L increased (p < 0.05) by 24 h compared to the control. The aerobic stability of P-silage inoculated with M increased (p < 0.05) by 6 h compared to the control. The improvement in fermentation quality and aerobic stability is extremely large in terms of applying M in F-silage and P-silage. The E is effective in improving the in vitro digestibility of P-silage. The research results provide a theoretical basis for the production of high-quality spent mushroom substrate fermented feed.
Seasonal and Diurnal Fluxes of Radiation, Heat, Water Vapor, and Carbon Dioxide over a Suburban Area

Abstract Based on 1 yr of field measurements, the diurnal, seasonal, and annual fluxes of energy and carbon dioxide (CO2) at a residential area of Tokyo, Japan, are described. The major findings are as follows. 1) The storage heat flux G in the daytime had little seasonal variation, irrespective of significant seasonal change of net all-wave radiation Rn. 2) The latent heat flux in the summer daytime was large despite the small areal fraction of natural coverage (trees and bare soil). The estimated local latent heat flux per unit natural coverage was 2 times the available energy (Rn − G), which indicates that the “oasis effect” was significant. 3) The CO2 flux was always upward throughout the year and the magnitude was larger in winter, mainly because of an increase of fossil fuel consumption. The annual total CO2 flux was 6 times the downward CO2 flux at a typical temperate deciduous forest.
Mechanism of skeletal muscle atrophy after spinal cord injury: A narrative review

Spinal cord injury leads to loss of innervation of skeletal muscle, decreased motor function, and significantly reduced load on skeletal muscle, resulting in atrophy. Factors such as braking, hormone level fluctuation, inflammation, and oxidative stress damage accelerate skeletal muscle atrophy. The atrophy process can result in skeletal muscle cell apoptosis, protein degradation, fat deposition, and other pathophysiological changes. Skeletal muscle atrophy not only hinders the recovery of motor function but is also closely related to many systemic dysfunctions, affecting the prognosis of patients with spinal cord injury. Extensive research on the mechanism of skeletal muscle atrophy and intervention at the molecular level has shown that inflammation and oxidative stress injury are the main mechanisms of skeletal muscle atrophy after spinal cord injury and that multiple pathways are involved. These may become targets of future clinical intervention. However, most of the experimental studies are still at the basic research stage and still have some limitations in clinical application, and most of the clinical treatments are focused on rehabilitation training, so how to develop more efficient interventions in clinical treatment still needs to be further explored. Therefore, this review focuses mainly on the mechanisms of skeletal muscle atrophy after spinal cord injury and summarizes the cytokines and signaling pathways associated with skeletal muscle atrophy in recent studies, hoping to provide new therapeutic ideas for future clinical work.
Interaction of Pu and Am with Bone Mineral In Vitro

Soluble forms of actinides such as Pu or Am that reach the blood deposit in significant quantity on bone surfaces and remain attached in the absence of bone remodelling. Removal of Pu or Am bone deposits with chelating agents such as diethylenetriaminepentaacetic acid (DTPA) is ineffective. and the search for better therapeutic approaches is hampered by a lack of understanding of the mechanisms by which transuranic elements bind to constituents of bone. Hypothesising that transuranics primarily bind with mineralised bone surfaces, specifically to bone hydroxyphosphates, an in vitro model comprising synthetic Ca hydroxyapatite (HAP) and other Ca phosphates. buffered at pH 7.2. was used to study the affinity of Pu and Am binding, and the effect of DTPA on binding to bone mineral. Samples containing 10 mg of bone mineral were equilibrated for 24 h in 0.1 M HEPES buffer and the pH adjusted to 7.2 ± 0.1. Either 238 Pu-citrate or 241 Am-citrate was added. and the suspension was sampled sequentially to determine the fractions of mineral-bound and unbound actinide using a centrifugal ultrafiltration system. From these experiments, it was determined that adding Na 3 ZnDTPA at physiologically relevant concentrations to suspensions in which Pu or Am were allowed to hind resulted in little or no removal of Pu. but a slight concentration- and time-dependent removal of Am from the hone mineral (maximum of 10% ultrafilterable in 24 h). In contrast, by using Na 5 DTPA, about 40% of the Pu and 60% of the Am were ultrafilterable at 48 h of incubation, suggesting that prior complexation of DTPA with Zn +2 prevented complexation with mineral-hound actinide. This has been attributed to steric hindrance. When Pu-DTPA or Am-DTPA was mixed with hone mineral. 40% of the Pu was dissociated from the DTPA and hound to the hone mineral; with Am. no dissociation was observed. These data indicate that the relative stability of binding of Am-DTPA was significantly greater than that of Am to bone mineral, but for Pu, the relative stabilities were more comparable. These results indicate the need for better chelation agents for removing hone-bound actinides.
Large-Eddy Simulation of Heavy-Particle Transport in Turbulent Channel Flow

Large-eddy simulations are carried out for a particle-laden vertical turbulent channel flow at Reynolds number of 180 based on friction velocity and channel half-width. To minimize the numerical and aliasing errors, a fourth-order compact finite-volume method in space and a fourth-order Runge-Kutta method in time along with a dynamic Smagorinsky model with explicit filter-grid size ratio 2 have been used to solve the filtered equations of the carrier flow. Heavy, small particle motion is governed by drag, gravitational, and Saffman lift forces in the Lagrangian frame. These particle equations are integrated in time using a second-order Adams-Bashforth method. The effect of subgrid-scale (SGS) fluctuations on particle statistics has been studied using two models available in the literature, with and without considering SGS velocity temporal correlation. In addition, a new model is implemented in this work to account for the anisotropy of flow. The results show that in the near-wall region the effect of SGS fluctuations on particle statistics is considerable, especially for small particle size of the order of 1μ m. The fluctuation levels of the wall-normal and spanwise directions of 1 − μ m lycopodium particle velocity are influenced strongly by SGS fluctuations and they are accentuated when the SGS effects are considered. The results for the 1 − μ m lycopodium particle show that the new model, which accounts for SGS anisotropy and Lagrangian temporal correlations of SGS fluctuations, yields improved results for particle turbulent intensity, especially in the near-wall region, when compared with other models. The effect of Saffman lift force on particle turbulent intensity is increased by increasing particle Reynolds number, especially in the wall-normal and spanwise directions.
Predissociation of the N+2(C 2Σ+u) state observed via C 2Σ+u → X 2Σ+g fluorescence after resonant 1s−1π* excitation of N2 molecule

Predissociation of the N+2 C 2Σ+u(v′) vibrational levels with v′ ⩾ 3 was observed via dispersed C 2Σ+u → X 2Σ+g fluorescence in the spectral range of 165–208 nm after resonant 1s−1π*(vr) excitation of N2 and its subsequent autoionization into the N+2 C state. This range is dominated by lines in atomic nitrogen, by overlapped C 2Σ+u(v′) → X 2Σ+g(v″) vibrational band sequences with Δv = const and broad unresolved band systems (D, (2))2Πg(v′) → A2Πu(v″) in the N+2 molecular ion. With very high fluorescence resolution of about 0.1 nm FWHM individual C 2Σ+u(v′) → X 2Σ+g(v″) vibrational bands have been resolved. Calculation of the observed fluorescence spectra by taking into account predissociation and molecular rotation describes well the shape of both individual vibrational bands C 2Σ+u(v′) → X 2Σ+g(v″) and the whole band system.
A low-noise 15-μm pixel-pitch 640×512 hybrid InGaAs image sensor for night vision

Hybrid InGaAs focal plane arrays are very interesting for night vision because they can benefit from the nightglow emission in the Short Wave Infrared band. Through a collaboration between III-V Lab and CEA-Léti, a 640x512 InGaAs image sensor with 15μm pixel pitch has been developed. The good crystalline quality of the InGaAs detectors opens the door to low dark current (around 20nA/cm2 at room temperature and -0.1V bias) as required for low light level imaging. In addition, the InP substrate can be removed to extend the detection range towards the visible spectrum. A custom readout IC (ROIC) has been designed in a standard CMOS 0. 18μm technology. The pixel circuit is based on a capacitive transimpedance amplifier (CTIA) with two selectable charge-to-voltage conversion gains. Relying on a thorough noise analysis, this input stage has been optimized to deliver low-noise performance in high-gain mode with a reasonable concession on dynamic range. The exposure time can be maximized up to the frame period thanks to a rolling shutter approach. The frame rate can be up to 120fps or 60fps if the Correlated Double Sampling (CDS) capability of the circuit is enabled. The first results show that the CDS is effective at removing the very low frequency noise present on the reference voltage in our test setup. In this way, the measured total dark noise is around 90 electrons in high-gain mode for 8.3ms exposure time. It is mainly dominated by the dark shot noise for a detector temperature settling around 30°C when not cooled. The readout noise measured with shorter exposure time is around 30 electrons for a dynamic range of 71dB in high-gain mode and 108 electrons for 79dB in low-gain mode.
Undermining teachers’ social capital: a question of trust, professionalism, and empowerment

Abstract The question of professional trust urgently needs closer attention in relation to teacher recruitment and retention, as this research shows it has significant bearing on the symbolic capital that may help to attract, motivate, and sustain high quality teachers. In Australian schools, teachers are frequently subject to initiatives to improve their practice, address their perceived limitations, and hold them accountable for failing students, schools, or systems. We argue that teachers, in the advent of these reforms intended to improve them, come to believe they are distrusted in their professional roles. Denying teachers the sense of themselves as capable professionals risks contributing to the problems of retention that are becoming ever more urgent in the Australian context and elsewhere in the world. This article explores the impacts of discourses and policy directions on teachers’ perceptions of professional trust. Drawing on case study data from two schools in the state of Victoria, Australia, we highlight the ways discourses of professional distrust emerge through policy directives that position teachers as ‘the problem’ in education.
Superductile bulk metallic glass

Usually, monolithic bulk metallic glasses undergo inhomogeneous plastic deformation and exhibit poor ductility (<2%) at room temperature. We report a newly developed Pd–Si binary bulk metallic glass, which exhibits a uniform plastic deformation and a large plastic engineering strain of 82% and a plastic true strain of 170%, together with initial strain hardening, slight strain softening and final strain hardening characteristics. The uniform shear deformation and the ultrahigh plasticity are mainly attributed to strain hardening, which results from the nanoscale inhomogeneity due to liquid phase separation. The formed nanoscale inhomogeneity will hinder, deflect, and bifurcate the propagation of shear bands.
Familial 4p Interstitial Deletion Provides New Insights and Candidate Genes Underlying This Rare Condition

Chromosome 4p deletions can lead to two distinct phenotypic outcomes: Wolf-–Hirschhorn syndrome (a terminal deletion at 4p16.3) and less frequently reported proximal interstitial deletions (4p11-p16). Proximal 4p interstitial deletions can result in mild to moderate intellectual disability, facial dysmorphisms, and a tall thin body habitus. To date, only 35 cases of proximal 4p interstitial deletions have been reported, and only two of these cases have been familial. The critical region for this syndrome has been narrowed down to 4p15.33-15.2, but the underlying causative genes remain unclear. In this study, we report the case of a 3-year-old female with failure to thrive, developmental and motor delays, and morphological features. The mother also had a 4p15.2-p14 deletion, and the proband was found to have a 13.4-Mb 4p15.2-p14 deletion by chromosome microarray analysis. The deleted region encompasses 16 genes, five of which have a high likelihood of contributing to the phenotype: PPARGC1A, DHX15, RBPJ, STIM2, and PCDH7. These findings suggest that multiple genes are involved in this rare proximal 4p interstitial deletion syndrome. This case highlights the need for healthcare providers to be aware of proximal 4p interstitial deletions and the potential phenotypic manifestations.
Ketamine Evolving Clinical Roles and Potential Effects with Cognitive, Motor and Driving Ability

While driving under the influence of drugs, drivers are more likely to be involved in and cause more accidents than drivers who do not drive under the influence. Ketamine is derived from phencyclidine and acts as a noncompetitive antagonist and allosteric modulator of N-methyl-D-aspartate receptors. Ketamine has been used to treat a variety of psychiatric disorders, with the most notable being treatment-resistant depression. With the rise of at-home ketamine treatment companies, the safety of unsupervised administration remains under evaluation. A study with ketamine and a ketamine-like medication, rapasitnel, showed that those who were given ketamine experienced more sleepiness and had decreased self-reported motivation and confidence in their driving abilities. Moreover, there seem to be significant differences in the acute versus persistent effects of ketamine, as well as the anesthetic versus subanesthetic doses, both in terms of effects and outcomes. These divergent effects complicate the clinical uses of ketamine, specifically involving driving, drowsiness, and cognitive abilities. This review aims to describe not only the various clinical uses of ketamine but also the potentially detrimental effects of driving under the influence, which should be understood to help with counseling the patients who use these substances, both for their well-being and to protect public safety.
Hematological Parameters in the First Trimester and the Risk of Gestational Diabetes Mellitus — Beijing, China, 2017–2020

What is already known about this topic? Hematological parameters may indicate the presence of chronic low-grade inflammation and increasing viscosity, which are involved in the pathological processes of gestational diabetes mellitus (GDM). However, the association between several hematological parameters in early pregnancy and GDM has yet to be elucidated. What is added by this report? Hematological parameters in the first trimester, particularly red blood cell (RBC) count and systematic immune index, have a significant impact on GDM incidence. The neutrophils (NEU) count in the first trimester was particularly pronounced for GDM. The upward trend of RBC, white blood cell (WBC), and NEU counts was consistent across all GDM subtypes. What are the implications for public health practice? Early pregnancy hematological parameters are associated with the risk of GDM.