Miracle-dz/UniFAR-FTUs huggingface dataset:
Long non-coding RNA FOXP4-AS1 is a prognostic biomarker and associated with immune infiltrates in ovarian serous cystadenocarcinoma

Abstract Background: FOXP4-AS1 expression participates in multiple signal pathways and has been previously reported in colorectal cancer, cervical cancer, and other cancer cells. However, its role on prognosis and immune infiltrates in ovarian serous cystadenocarcinoma (OVs) remains unclear. The purpose of our study was to investigate the expression of FOXP4-AS1 in OVs and its association with immune infiltrates, and determined its prognostic roles in OVs. Methods: Using The Cancer Genome Atlas (TCGA) database, we retrieved FOXP4-AS1 expression and clinical information for 376 patients with OVs. Wilcoxon rank sum test was used to compare the expression of FOXP4-AS1 in OVs and normal ovarian tissue. Logistic regression was used to analyze the relationship between clinicopathologic features and FOXP4-AS1. Gene Set Enrichment Analysis (GSEA), and single sample Gene Set Enrichment Analysis (ssGSEA) was conducted to investigate the enrich pathways and functions and quantify the extent of immune cells infiltration for FOXP4-AS1. Kaplan–Meier method was used to generate survival curves, and Cox regression was used to analyze the relationship between FOXP4-AS1 and survival rate. Results: High FOXP4-AS1 expression was significantly correlated with tumor FIGO stage (P = .026). Multivariate survival analysis showed that FOXP4-AS1was an independent prognostic marker for overall survival (OS; hazard ratio [HR]: 0.638; 95% confidence interval [CI]:0.467–0.871; P = .001) and disease-specific survival (DSS; HR: 0.649; CI: 0.476–0.885; P = .006). GSEA showed that High FOXP4-AS1 expression may active programmed cell death 1 (PD-1) signaling, the cytotoxic T lymphocyte-associated antigen-4 (CTLA4) pathway, the B cell receptor signaling pathway, apoptosis, fibroblast growth factor receptor (FGFR) signaling, and the Janus-activated kinase signal transducers and activators of transcription (JAK-STAT) signaling pathway. FOXP4-AS1 expression was negatively correlated with markers of immune cells, including aDC, cytotoxic cells and neutrophils. Conclusion: High FOXP4-AS1 expression has the potential to be a prognostic molecular marker of favorable survival in OVs.
S1759078720001452jra 897..914

Sub-beam concept is very useful for size reduction of multiple beam phased array antenna (PAA) systems that are applied for high-throughput communication satellites. In this paper, the synthesis procedure for a PAA with multiple sub-beams in two dimensions of the coverage domain is proposed and analyzed. In the design procedure, the interleaved sub-arraying technique has been applied to eliminate the grating lobes. The extremely short angular distance between adjacent sub-beams is challenging. An innovative beam forming network is proposed, which can generate multiple orthogonal sub-beams while keeping the required angular distance between sub-beams. To demonstrate the effectiveness of the design technique, an example considering the requirements derived from conceptual design of a high-throughput communication payload is presented. The array is optimized using the genetic algorithm while taking into account the technical requirements of the antenna. The gain patterns exhibit a 0.4° angular distance between adjacent sub-beams. In addition, the number of sub-arrays and element spacing guarantee the orthogonality of the sub-beams. The calculated carrier to interference ratio in the synthesized array shows that it has acceptable values in each spot. The aperture size reduction in the synthesized array compared to a conventional multiple beam array is more than 36.7%.
A comparison of soil tests for available phosphorus in long‐term field experiments in Europe

Most soil tests for available phosphorus (P) perform rather poorly in predicting crop response. This study was set up to compare different established soil tests in their capacity to predict crop response across contrasting types of soil. Soil samples from long‐term field experiments, the oldest >100 years old, were collected in five European countries. The total number of soil samples (n = 218), which differed in cropping and P treatment, and originated from 11 different soil types, were analysed with five tests: ammonium oxalate (Ox), ammonium lactate (AL), Olsen P, 0.01 m CaCl2 and the diffusive gradient in thin film (DGT). The first three tests denote available P quantity (Q), whereas the last two indicate P intensity (I) of the soil solution. All five tests were positively related to the crop yield data (n = 317). The Q‐tests generally outperformed I‐tests when evaluated with goodness of fit in Mitscherlich models, but critical P values of the I‐tests varied the least among different types of soil. No test was clearly superior to the others, except for the oxalate extraction, which was generally poor. The combination of Q‐ and I‐tests performed slightly better for predicting crop yield than any single soil P test. This Q + I analysis explains why recent successes with I‐tests (e.g. DGT) were found for soils with larger P sorption than for those in the present study. This systematic evaluation of soil tests using a unique compilation of established field trials provides critical soil P values that are valid across Europe.
Mass Spectrometry of Non-allomerized Chlorophylls a and b Derivatives from Plants

Background: Non-allomerized chlorophylls a and b are part of a great diversity of environments: senescent and ripened vegetal tissues, processed foods, sediments, fecal pellets, etc. Consequently, the articles characterizing their mass spectrometry behavior belong to a variety of disciplines. Objective: To compile in a single review all the information published related to mass spectrometry of 26 chlorophyll derivatives, including chlorophyllides, pheophorbides, pheophytins, and hydroxy-, lactone-, and pyro-chlorophyll derivatives. Method: A detailed and extensive bibliographic search through the Web of Science TM followed by a comprehensive and critic discussion. Results: This review gathers all the information concerning mass spectroscopic characteristics published for each non-allomerized chlorophyll of a and b series. This means that for each one of the 26 chlorophyll derivatives, it has been compiled the complete information published of mass (or exact mass), mass spectrometry technique and equipment (ionization method and mass analyzer), product ions, structural assignments and proposed mechanisms (if available), detailing the references. Conclusion: The evaluation of referenced data in literature has allowed to obtain common characteristics in the mass spectrometry behavior between the different chlorophyll derivatives. In addition, specific product ions have been reported, revealing specific structural modifications in the chlorophyll molecule, facilitating the structural characterization. This review embraces the application of predictive software tools, which improve accuracy of predictions and make straightforward the structural assignments. FD:
Torricelli’s law revisited

Suppose a tank initially full of water is drained through a small hole at the bottom. At what rate does the water level drop? How long does it take to empty the tank? A mathematical model is formulated to answer these questions. An experiment is also conducted to check if the prediction agrees with observation. A novel modification to the mathematical model is presented to bring theory and observation in harmony. This involves accounting for the non-uniform velocity profile through the exit hole. Unsteady effects resulting from the acceleration of the fluid is also explored theoretically. The problem and solution procedure is suitable for an introductory physics course.
Why Do M Dwarfs Have More Transiting Planets?

We propose a planet formation scenario to explain the elevated occurrence rates of transiting planets around M dwarfs compared to Sun-like stars discovered by Kepler. We use a pebble drift and accretion model to simulate the growth of planet cores inside and outside of the snow line. A smaller pebble size interior to the snow line delays the growth of super-Earths, allowing giant planet cores in the outer disk to form first. When those giant planets reach pebble isolation mass they cut off the flow of pebbles to the inner disk and prevent the formation of close-in super-Earths. We apply this model to stars with masses between 0.1 and 2 M ⊙ and for a range of initial disk masses. We find that the masses of hot super-Earths and of cold giant planets are anticorrelated. The fraction of our simulations that form hot super-Earths is higher around lower-mass stars and matches the exoplanet occurrence rates from Kepler. The fraction of simulations forming cold giant planets is consistent with the stellar mass dependence from radial-velocity surveys. A key testable prediction of the pebble accretion hypothesis is that the occurrence rates of super-Earths should decrease again for M dwarfs near the substellar boundary like Trappist-1.
Research on the Application of Thermoelectric Potential Technology in Austenitic Heat-resistant Steel During Aging

HR3C heat-resistant steel is an important material for ultra-supercritical units. The results of the current study show that HR3C heat resistant steel suffers from a significant short term reduction in impact power under long term high temperature conditions. In this paper, through the austenitic heat-resistant steel HR3C through a long time high-temperature aging heat treatment, the results show that after high-temperature aging HR3C significant characteristics of its grain boundaries precipitation of a large number of M23C6 phase, the austenite grains will be closely wrapped, is the main cause of the HR3C impact power found to be significantly reduced. In addition, the thermoelectric potential non-destructive testing technique can better characterise the changes in the characteristics of HR3C heat resistant steel during the long term thermal ageing process and has a greater engineering application in monitoring changes in the properties of HR3C materials, affecting the results of HR3C thermoelectric potential testing in relation to the second phase produced during its thermal ageing process.
Screening bamboo species for salt tolerance using growth parameters, physiological response and osmolytes accumulation as effective indicators

ABSTRACT Bamboos are potential species for reclamation of saline soils and water. In this study, the performances of three bamboo species, namely Dendrocalamus strictus (S1), Dendrocalamus longispathus (S2) and Bambusa bambos (S3), were investigated for salinity stress tolerance. After 14 days of treatment with 100 mM NaCl, reduction in shoot length was 66%, 100%, 77%, root length was 77%, 100%, 57%, number of leaves was 50%, 100%, 73% and fresh weight was 30%, 72%, 14% in S1, S2 and S3 species, respectively. Relative water content (RWC) in S1 and S3 species was 1.26 and 1.07 folds higher in 50 mM NaCl in comparison to control. In S2 species, total chlorophyll, chlorophylla and chlorophyllb degradation were the highest (40.4%, 42.7%, 16.32%, respectively) in comparison to S3 (18.18%, 23%, 16.4%) and S1 (23.5%, 25%, 19.17%) species. In S3 and S1 species, the Chla/Chlb ratio was maintained showing stabilisation of the net photosynthetic rate. Proline played a more important role than glycine betaine for salt tolerance of these bamboo species. On account of vegetative growth, proline accumulation and RWC, it is inferred that S1 and S3 species are salt tolerant while S2 is a sensitive species. Abbreviations: SL: shoot length; RL: root length; NL: number of leaves; FW: fresh weight; RWC: relative water content; Chla: chlorophylla; Chlb: chlorophyllb; TC: total chlorophyll; GB: glycine betaine
Methicillin-resistant Staphylococcus aureus isolates from Iranian restaurant food samples: Panton-Valentine Leukocidin, SCCmec phenotypes and antimicrobial resistance

Purpose: To assess the distribution of Panton-Valentine Leukocidin, SCCmec types and antimicrobial resistance pattern of methicillin resistant Staphylococcus aureus isolated from restaurant food. Methods: Five-hundred and eighty food samples were collected and directly transported to the laboratory. Samples were cultured and S. aureus strains were confirmed using biochemical tests. MRSA strains were determined using polymerase chain reaction (PCR)-based amplification of mecA and femA genes. MRSA strains were then subjected to disk diffusion methods. Results: One-hundred and nineteen out of 580 samples (20.51 %) were positive for S. aureus . Eightythree out of 119 S. aureus (69.74 %) were methicillin-resistant. Thirty-nine out of 83 MRSA samples (46.98 %) harbored PVL gene. Cooked chicken (37 %) had the highest prevalence of S. aureus . Marked seasonality was observed for the prevalence of bacteria. MRSA strains exhibited high resistance against penicillin G (100 %), tetracycline (92.77 %), oxacillin (83.13 %) and azithromycin (71.08 %). All MRSA bacteria were resistant to at least 2 antibiotics (100 %). TetK (80.72 %), linA (67.46 %), aadA1 (62.65 %), and msrA (55.42 %) were the most frequently identified resistance genes. SCCmec V (57.83%), SCCmec Iva (55.42 %) and SCCmec IVb (30.12 %) were the most frequent. Conclusion: Based on the high prevalence of resistant MRSA strains and also high consumption rate of restaurant foods in Iran, it is essential to exercise control over the hygienic conditions of restaurant foods to minimize MRSA strains. Keywords: Methicillin-resistant Staphylococcus aureus (MRSA), Antibiotic resistance, SCCmec types, Panton-Valentine Leukocidin, Restaurant food
Current state of professional Neuropsychological practice in Mexico

The objective of this study was to analyze the characteristics of the profession of neuropsychology in Mexico, including the background, professional training, current work situation, evaluation and diagnosis procedures, rehabilitation, teaching, and research. 171 professionals from Mexico completed an online survey between July 1 2013 and January 1 of 2014. 76% indicated having obtained their training in neuropsychology in a postgraduate program, also to be very satisfied with their jobs but less satisfied with their salary. The majority works with individuals with learning difficulties (78%) and attention and hyperactivity disorder (74%). 91% works in evaluation and diagnosis, 61% in rehabilitation, 67% in teaching, and 60% in research. Some of the most common problems with the instruments were the lack of normative data (63%) and their high cost (58%). The most common barriers for the development of neuropsychology in Mexico were the lack of collaboration between professionals and, the lack of clinical training programs. Even though there have been important progresses in the field of professional neuropsychological practice during the last past decades in Mexico, there are still some aspects to improve, like the establishment of standards for the regulation in the country.
Genetic divergence analysis in muskmelon (Cucumis melo L.)

Twenty five genotypes of muskmelon (Cucumis melo L.) were evaluated in a randomized block design with three replications at the vegetable farm, College of Horticulture, Anantharajupeta, Andhra Pradesh, India during late kharif (August 2017 to December 2017) for assessment of genetic diversity based on 29 morphological traits. Cluster analysis revealed distinct clustering pattern and grouping of genotypes in to six clusters. Cluster II was the largest (7 genotypes) followed by cluster I and III (5 genotypes) followed by cluster IV (3 genotypes), while cluster VI consisted of only one genotype. Intra cluster D2 values ranged from 0.00 (cluster VI) to 1980.14 (cluster II) while, intercluster D2 values ranged from 2286.05 (cluster I and II) to 17401 (cluster VI and V). Cluster V and VI were extremely diverse from the rest of the clusters. Hence the genotypes falling in these clusters being genetically more divergent, can be used in hybridization programme.
Identification of Dyes in Pen Ink by High Resolution Mass Spectrometry: A Laboratory Experiment

In this experiment, students develop their knowledge of mass spectrometry to identify dyes in different commercial pen ink entries on paper using a simple method based on liquid-solid extraction and high-resolution mass spectrometry. In short, students will first extract the dyes in the ink from the paper with a 1:1 solution of water and methanol. The sample is then analyzed by matrix assisted laser desorption/ionization quadrupole time-of-flight mass spectrometer (MALDI-QTOFMS). Inks from three commercial inks were analyzed and they could be differentiated according to the presence of peaks in the mass spectrum corresponding to specific dyes. Key concepts in mass spectrometry such as resolution, mass accuracy and formula determination can be taught with the acquired data. A forensic activity could also be added to enhance the interest of students for mass spectrometry and its applications. This laboratory experiment is expected to be performed in a four-hour laboratory period by sophomore or junior students. To summarize, this experiment provides an interesting introduction to fundamental concepts of mass spectrometry.
The Effects of the COVID-19 Pandemic on the Mental Health and Subjective Well-Being of Workers: An Event Study Based on High-Frequency Panel Data

Using individual monthly panel data from December 2018 to December 2020, we estimate the impact of the Covid-19 pandemic and two lockdowns on the mental health and subjective well-being of German workers. Employing an event-study design using individual-specific fixed effects, we find that the first and the second wave of the pandemic reduced workers' mental health substantially. Momentary happiness and life satisfaction also decline in response to Covid-19, but to a smaller extent. We observe adapation in our study outcomes between waves of the pandemic. This applies to a lesser extent to indicators of well-being in certain areas of life, such as satisfaction with the job and with leisure, which are negatively affected, too. Women do not seem to suffer greater well-being losses than men. However, workers in the German short-time work scheme are particularly negatively affected. Our results imply that increased anxiety about the future and restricted personal freedoms are among the drivers of the well-being impact of the pandemic.
Preparation of Mullite-Silica Composites Using Silica-Rich Monophasic Precursor Obtained as a Byproduct of Mineral Carbonation of Blast-Furnace Slag

Previously, mineral carbonation of blast-furnace slag was carried out to sequestrate CO2 and attain pure CaCO3 crystals. In this process, amorphous silica-alumina nanoparticles were obtained as a byproduct. In this study, the crystallization of these nanoparticles on calcination at various temperatures in air was examined using TGA-DTA, XRD, MAS-NMR spectroscopy, and FT-IR spectroscopy. The precursor nanoparticles (Si:Al = 78:22 mol %) were prepared using the solution extracted from blast-furnace slag (BFS) with acetic acid at room temperature. The XRD analysis showed that the initial amorphous state was retained up to 800 °C, and decomposition to amorphous silica and mullite started after calcination at 950 °C. At temperatures between 1150 °C and 1250 °C, amorphous silica crystalized to cristobalite, which eventually melted to glassy silica at 1500 °C. The mullite crystals initially adopted a metastable tetragonal phase and transformed to a stable, needle-like orthorhombic phase at higher temperatures. 27Al MAS-NMR spectroscopy revealed that octahedrally coordinated Al was favored up to a temperature of 800 °C as a result of the dehydration process and transformed into tetrahedrally coordinated Al at higher temperatures. A microstructural examination revealed that the initially randomly-oriented mullite developed into stable, needle-like grains owing to anisotropic grain growth in the presence of a glass phase at high temperatures. This study suggests that the recycling of BFS can be exploited for the procurement of a mullite-type ceramic material.
Genetic diversity of sugarcane (Saccharum Officinarum L.) based on morphological characters

Sugarcane (Saccharum officinarum L.) is an important plantation crop in the commercial sector as it accounts for 65% of worldwide sugar production. The role of sugarcane is very important in the sugar industry, so it needs to be supported by intensive research, especially for the breeding and assembly of superior varieties to improve the quality and quantity of sugarcane production. The process of plant breeding cannot be separated from the germplasm management program, because it is a source of genetic diversity of a plant species. Characteristics and evaluation of nuftah plasma are one of the activities carried out to determine the potential characteristics of the breeding program. One of the efforts to extract information in empowering the nuftah plasma collection is by morphological characteristics, so that superior plant varieties or accessions can be classified. Morphological characters were observed qualitatively and quantitatively. Each variety of a sugarcane species has a specific morphological description, both quantitative and qualitative traits, then the data base for these characteristics is used as a reference for filtering potentially superior to diversity in germplasm collections.
Plasma-assisted catalysis for air purification

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Effects of Different Processing Methods on the Chemical Compositions of Mucuna pruriens Leaves

The study was to evaluate the effects of different processing methods on the proximate and anti-nutritional contents of Mucuna pruriens leaf meal. The Mucuna pruriens leaves were collected and processed by Air-dried Mucuna Leaf Meal (AMLM), Soaked Mucuna Leaf Meal in Cold Water (CMLM), Soaked Mucuna Leaf Meal in Hot Water (HMLM) and Fermented Mucuna Leaf Meal (FMLM). Proximate analysis showed that FMLM had the highest value (25.94±0.94%), while the lowest recorded in the CMLM (23.00±0.00%). The analysis of anti-nutritional factors showed that hydrocyanic acid, oxalate, phytate, saponin, reduced significantly (P<0.05) after processing the Mucuna Leaf Meal. Keywords: Mucuna pruriens leaves, proximate composition, anti-nutrients, air-dried, soakings, fermented.
Facile One-Pot Synthesis of CoFe Alloy Nanoparticles Decorated N-Doped Carbon for High-Performance Rechargeable Zinc–Air Battery Stacks

We report the facile one-pot synthesis of CoFe alloy nanoparticles decorated N-doped carbon (CoFe/N–C) from commercial Vulcan carbon black and transition metal salts. With ∼8.0 wt % of metal in the composite catalyst, efficient catalysis toward the oxygen reduction reaction (ORR) can be achieved with a pseudo-four-electron transfer per oxygen molecule, outperforming the benchmark catalyst, Pt/C, by a more positive onset potential, and smaller half-wave potential and Tafel slope. A rechargeable battery stack built from five zinc–air cells in series gives a power output of up to 28.5 W. Benefiting from its low internal resistance, the battery stack can deliver a high current of 8.4 A and a stable discharge voltage above 5.5 V over 180 cycles, showing potential as a basic unit for grid-scale energy storage.