Miracle-dz/UniFAR-FTUs huggingface dataset:
Inflammation, Biomarkers and Personalized Therapies in Pancreatic Cancer

It is estimated that pancreatic cancer will be the 2nd leading cause of cancer-related deaths globally by 2030, highlighting the ongoing lack of effective treatment options in this devastating condition. There is a lack of reliable prognostic or predictive markers in pancreatic cancer to guide management decisions, whether for systemic chemotherapy, molecularly targeted therapies, or immunotherapies. To date, the results for targeted agents and immunotherapies in unselected populations of chemo-refractory pancreatic cancer have not met expectations. The reasons for this lack of efficacy of immunotherapy in pancreatic cancer are incompletely understood. The challenges in pancreatic cancer include the physical barrier created by the dense desmoplastic stroma surrounding the tumor, chemokine-mediated exclusion of T cells, poor antigenicity, paucity of infiltrating T cells within the tumor, ultimately leading to an immunosuppressive microenvironment. A better understanding of the role of inflammation in pancreatic cancer, its tumor microenvironment and individualized patient-related features, be they molecular, clinical or histopathological would enable a more effective tailored approach to the management of pancreatic cancer. In this review, the role of inflammation, the immune tumor microenvironment and potential immune biomarkers in pancreatic cancer are explored.
The Impact of Perceived Value on Customer Loyalty: A Case Study of GrabFood Consumers

This research aims to identify the impact of perceived value on customer loyalty in the case study of GrabFood consumers in Jakarta. Perceived value is measured through customer-perceived benefits and sacrifices. The data was collected from 190 customers who have downloaded and used GrabFood. Multiple linear regressions were used to examine the collected data. The finding indicates that perceived value significantly impacts the loyalty of GrabFood customers. All indicators of perceived benefits impact customer loyalty, and the strongest influence on customer loyalty is perceived enjoyment, while the least is perceived money saving. Meanwhile, the quality risk becomes the only indicator of customer perceived sacrifices that impact customer loyalty. Perceived fee, delivery risk, and privacy risk are found to have no significant impact on customer loyalty. This study provides several suggestions for Grab Indonesia to enhance customer loyalty towards GrabFood by considering perceived benefits and sacrifices as determinants of perceived value.
Marburg and Ebola viruses

PRINTED FROM OXFORD MEDICINE ONLINE (www.oxfordmedicine.com). (c) Oxford University Press, 2014. All Rights Reserved. Under the terms of the l icence agreement, an individual user may print out a PDF of a single chapter of a title in Oxford Medicine Online for personal use (for details see Privacy Policy). date: 14 October 2014 Publisher: Oxford University Press Print Publication Date: Jul 2011 Print ISBN-13: 9780198570028 Published online: Jul 2011 DOI: 10.1093/med/9780198570028.001. 0001
Correlations between Total Antioxidant Capacity and 8-Hydroxydeoxyguanosine with Carotid-Femoral Pulse Wave Velocity in Chronic Kidney Disease

BACKGROUND: Chronic kidney disease (CKD) is often associated with an increased risk of cardiovascular disease. Cardiovascular disease in CKD can be affected by oxidative stress and inflammation. The oxidative stress can affect arterial stiffness, especially in patients with CKD, which will increase the risk of cardiovascular disease. This study aimed to explain the correlation between total antioxidant capacity (TAC) and 8-hydroxydeoxyguanosine (8-OHdG) with carotid-femoral pulse wave velocity (cf-PWV) in patients with CKD.METHODS: Forty-three CKD patients was included in this cross-sectional study. TAC was measured from serum samples by colorimetric method and 8-OHDG was measured from urine by enzyme-linked immunoassay method. cf-PWV was measured by Doppler ultrasound as a diagnostic tool for arterial stiffness.RESULTS: Significant correlations were found between age, estimated glomerular filtration rate (e-GFR), Hemoglobin A1C (HbA1C), serum creatinine, cystatin-C, and severity of CKD with urinary 8-OHdG levels. Serum creatinine, cystatin-C, severity of CKD, age, high-density lipoprotein (HDL), e-GFR, and HbA1C also had significant correlations with serum TAC levels. Other significant correlations between e-GFR, HbA1C, serum creatinine, cystatin-C, and severity of CKD with cf-PWV were also obtained. A significant negative correlation was obtained between serum TAC and cf-PWV with moderate levels of correlation coefficient (r=-0.504). CONCLUSION: There was a negative correlation between TAC and cf-PWV, but there was no significant correlation between 8-OHdG and cf-PWV in patients with CKD.KEYWORDS: chronic kidney disease, total antioxidant capacity, 8-hydroxydeoxyguanosine, carotid-femoral pulse wave velocity
Weedy rices : origin, biology, ecology and control

This publication presents a compilation of information from literature reviews on the body of knowledge available from ongoing unpublished research, research reports and symposia carried out on various aspects of the importance, ecology, biology and control of weedy rices. It also highlights global economic and environmental problems created by weedy rices, including red rice types. This document is a result of FAO partnership arrangements with institutions of excellence to generate information that will be for general public use in an attempt to fulfil the goal of food security. Since this publication will interest a wide range of stakeholders - policy-makers, scientists, technicians and producers - including those interested in rice crop research, production, rice milling for commerce, quarantine regulations and seed trade, an attempt has been made to define weedy, wild and red rice so as to engender a common understanding of various aspects of this group of pests. The information provided will contribute to the better knowledge of weedy rices throughout the world.
Effects on cardiopulmonary parameters of propofol, Ketofol and Etomidate as induction agent in glycopyrrolate premedicated dogs maintained under isoflurane anaesthesia

The present study was undertaken in 18 dogs with elective surgery (castration, spaying etc.) to evaluate the effect of propofol, ketofol and etomidate as induction agents in glycopyrrolate premedicated dogs maintained with isoflurane. The animals were randomly divided into three groups viz. group P, KP & E, comprising six animals in each group. All the animals of the three groups were premedicated with glycopyrrolate @ 0.01 mg/kg IM, 10 minutes prior induction. Propofol @ 6mg/kg IV, ketofol @ 4mg/kg and etomidate @ 3mg/kg was administered as induction agent in group P, KP and E respectively. Maintenance of anaesthesia was carried out by using isoflurane in all the animals. Cardiopulmonary parameters were studied at (baseline) 0 min and thereafter 5, 15, 30, and 60 minutes after induction. Heart rate significantly (P< 0.01) increased in all the groups compared to baseline at 5 min time interval and then gradually decreased towards the baseline. Respiration rate significantly (P< 0.01) decreased in group KP but non significantly in group P and E. Rectal temperature significantly (P< 0.01) decreased in group P and KP but non significantly decreased in group E. Significant (P< 0.05) decrease in SpO2 was observed in group P whereas significant (P< 0.01) decrease in SpO2 was observed in group KP and E followed by gradual increase in SpO2 in all three groups Non significant increase in ETCO2 followed by gradual decrease towards the baseline was observed in all three groups. Significant (P< 0.01) decrease in SP and DP was observed in group P whereas significant (P< 0.01) increase in SP and DP was observed in group KP. In group E non significant changes were observed in group E.
Water Mite Diversity (Acariformes: Prostigmata: Parasitengonina: Hydrachnidiae) from Karst Ecosystems in Southern of Mexico: A Barcoding Approach

Water mites represent the most diverse and abundant group of Arachnida in freshwater ecosystems, with about 6000 species described; however, it is estimated that this number represents only 30% of the total expected species. Despite having strong biotic interactions with their community and having the potential to be exceptional bioindicators, they are frequently excluded from studies of water quality or ecology, due to actual and perceived difficulties of taxonomic identification in this group. The objective of this study is to use the variations in the sequences of the mitochondrial cytochrome oxidase subunit I (COI), also known as the DNA barcodes region, as a tool to assess the diversity of water mites at 24 sites in the Yucatan Peninsula of Mexico. We found 77 genetic groups or putative species corresponding to 18 genera: Arrenurus, Atractides, Centrolimnesia, Eylais, Geayia, Hydrodroma, Hydryphantes, Hygrobates, Koenikea, Krendowskia, Limnesia, Limnochares, Mamersellides, Mideopsis, Neumania, Piona, Torrenticola, and Unionicola. This was significant, since there are only 35 species described for this region. Furthermore, this molecular information has allowed us to infer that there are characteristic assemblies per site. These data will facilitate the incorporation of water mites in different studies while the curatorial work continues to assign a Linnaean name.
OP-ICBJ200038 563..580

*Department of Biology, University of Konstanz, Konstanz, 78464, Germany; Friday Harbor Laboratories, School of Aquatic and Fishery Sciences, Department of Biology, University of Washington, WA 98195, USA; Department of Earth Sciences, Natural History Museum, London SW7 5HD, UK; Department of Molecular and Cell Biology, University of California Berkeley, Berkeley, CA 94720, USA; Department of Ecology and Evolution, University of California Los Angeles, Los Angeles, CA 90032, USA; kDepartment of Biology, University of Florida, Gainesville, FL 32611, USA
First magmatism in the New England Orogen, Australia: Forearc and arc-backarc components in the Bakers Creek Suite gabbros

The New England Orogen, Eastern Australia, was established as an outboard extension of the Lachlan Orogen through the migration of magmatism into the forearc basin and accretionary prism. Widespread S-type granitic rocks of the Hillgrove and Bundarra Supersuites represent the first pulse of magmatism, followed by Iand A-types typical of circum10 Pacific extensional accretionary orogens. Associated with the former are a number of small tholeiite-gabbroic to intermediate bodies of the Bakers Creek Suite, which are a heat source for production of granitic magmas and potential tectonic markers indicating why magmatism moved into the forearc and accretionary complexes, rather than rifting the old Lachlan Orogen arc. The Bakers Creek suite gabbros capture an early (~305 Ma) forearc basalt-like component with low Th/Nb and with high Y/Zr and Ba/La, recording melting in the mantle wedge with little involvement of a slab flux and indicating forearc 15 rifting. Subsequently, arc-backarc like gabbroic magmas (305-304 Ma) were emplaced followed by diverse magmatism of mixed compositions leading up to the main S-type granitic intrusion (~290 Ma). This trend in magmatic evolution implicates forearc and other mantle wedge melts in the heating and melting of fertile accretion complex sediments and relatively long (~10 Myr) timescales for such melting.
Comparison of Anesthesia-Controlled Operating Room Time Between Propofol-Based Total Intravenous Anesthesia and Desflurane Anesthesia in Open Liver Resection: A Retrospective Study.

BACKGROUND Reducing anesthesia-controlled time (ACT) such as extubation time may improve operation room (OR) efficiency result from different anesthetic techniques. However, the information about the difference in ACT between desflurane (DES) anesthesia and propofol-based total intravenous anesthesia (TIVA) techniques for open liver resection under general anesthesia is not available in the literature. METHODS This retrospective study uses our hospital database to analyze the ACT of open liver resection after either DES/fentanyl-based anesthesia or TIVA via target-controlled infusion (TCI) with fentanyl/propofol from January 2010 to December 2011. The various time intervals including waiting for anesthesia time, anesthesia time, surgical time, extubation time, exit from OR after extubation, total OR time, and post-anesthetic care unit stay time and percentage of prolonged extubation (≥ 15 minutes) were compared between the two anesthetic techniques. RESULTS We included 143 hepatocellular carcinoma patients, with 82 patients receiving TIVA and 61 patients receiving DES. The extubation time was faster (10.1 ± 3.2 min vs. 11.8 ± 5.2 min; P = 0.03), and the incidence of prolonged extubation was lower (9.8% vs. 26.8%; P = 0.02) in the DES group than in the TIVA group. The factors contributed to prolonged extubation were age, sex, anesthetic technique, and anesthesia time. CONCLUSION The DES anesthesia provided faster extubation time and lower incidence of prolonged extubation compared with propofol-based TIVA by TCI in elective open liver resection. Besides, older age, male, TIVA, and lengthy anesthesia time were factors affecting prolonged extubation.
Identification and localization of enzymes of the fumarate reductase and nitrate respiration systems of escherichia coli by crossed immunoelectrophoresis

Crossed immunoelectrophoresis was used to analyze the components of membrane vesicles of anaerobically grown Escherichia coli. The number of precipitation lines in the crossed immunoelectrophoresis patterns of membrane vesicles isolated from E. coli grown anaerobically on glucose plus nitrate and on glycerol plus fumarate were 83 and 70, respectively. Zymogram staining techniques were used to identify immunoprecipitates corresponding to nitrate reductase, formate dehydrogenase, fumarate reductase, and glycerol-3-phosphate dehydrogenase in crossed immunoelectrophoresis reference patterns. The identification of fumarate reductase by its succinate oxidizing activity was confirmed with purified enzyme and with mutants lacking or overproducing this enzyme. In addition, precipitation lines were found for hydrogenase, cytochrome oxidase, the membrane-bound ATPase, and the dehydrogenases for succinate, malate, dihydroorotate, D-lactate, 6-phosphogluconate, and NADH. Adsorption experiments with intact and solubilized membrane vesicles showed that fumarate reductase, hydrogenase, glycerol-3-phosphate dehydrogenase, nitrate reductase, and ATPase are located at the inner surface of the cytoplasmic membrane; on the other hand, the results suggest that formate dehydrogenase is a transmembrane protein.
Health-Related Perception and Responsibility Behavior Among Individuals With and Without Chronic Illness

Few studies have examined perceptions of responsibility attribution and well-being, and health responsibility behaviors in individuals with none, one, and multiple chronic illnesses. Adults (N = 421) in medical clinics completed questionnaires for this cross-sectional descriptive study. The Revised Causal Dimensional Scale measured responsibility attribution whereas sub-sections of the Chronic Disease Self-Management Program evaluation measured well-being perception and the health responsibility behavior of communication associated with a clinic visit. Chi-square, Wilcoxon-Mann-Whitney U, and Kruskal-Wallace tests were used to examine demographic characteristics and group differences. Individuals with multiple morbidities and of advanced age perceived their illnesses as more stable and rated their well-being lowest. Females, participants of advanced age, and living with a partner engaged more in health communication. More information about responsibility attribution and chronic illness management is needed. Study results suggest regular assessment of well-being perception and communication training for individuals >45 years to support multiple chronic illness management.
Proteus sp. – an opportunistic bacterial pathogen – classification, swarming growth, clinical significance and virulence factors

The genus Proteus belongs to the Enterobacteriaceae family, where it is placed in the tribe Proteeae, together with the genera Morganella and Providencia. Currently, the genus Proteus consists of five species: P. mirabilis, P. vulgaris, P. penneri, P. hauseri and P. myxofaciens, as well as three unnamed Proteus genomospecies. The most defining characteristic of Proteus bacteria is a swarming phenomenon, a multicellular differentiation process of short rods to elongated swarmer cells. It allows population of bacteria to migrate on solid surface. Proteus bacteria inhabit the environment and are also present in the intestines of humans and animals. These microorganisms under favorable conditions cause a number of infections including urinary tract infections (UTIs), wound infections, meningitis in neonates or infants and rheumatoid arthritis. Therefore, Proteus is known as a bacterial opportunistic pathogen. It causes complicated UTIs with a higher frequency, compared to other uropathogens. Proteus infections are accompanied by a formation of urinary stones, containing struvite and carbonate apatite. The virulence of Proteus rods has been related to several factors including fimbriae, flagella, enzymes (urease hydrolyzing urea to CO2 and NH3, proteases degrading antibodies, tissue matrix proteins and proteins of the complement system), iron acqusition systems and toxins: hemolysins, Proteus toxin agglutinin (Pta), as well as an endotoxin lipopolysaccharide (LPS). Proteus rods form biofilm, particularly on the surface of urinary catheters, which can lead to serious consequences for patients. In this review we present factors involved in the regulation of swarming phenomenon, discuss the role of particular pathogenic features of Proteus spp. , and characterize biofilm formation by these bacteria.
Determining yield components in pumpkin through correlation and path analysis

Correlation and path coefficient analysis of 50 pumpkin germplasm lines for 17 characters was conducted at Pantnagar (Uttaranchal) during summer 2002–2003. The characters showing positive and highly significant correlation with fruit yield were fruit diameter, number of ridges per fruit, fruit flesh thickness, vine length and number of fruits per plant. Yield had negative and significant correlation with days to first male and female flower and seed cavity depth. There was a positive and direct effect on fruit yield for the traits like days to anthesis of first female flower, fruit flesh thickness, node numbers to first female flower, fruit diameter and vine length.
The relation of leadership style and emotional intelligence and job satisfaction of lifeguard staff of the country

† Administration and management of sports organization should completely get ready to adapt itself with the world of professional sports today. The goal of this paper is studying the relation of leadership style and emotional intelligence and job satisfaction of lifeguard staff of the country. Research methodology of this paper was correlation. Statistical society of this paper was the whole lifeguard staff of country which their number were 120 and they have chosen randomly. For collecting information from three questionnaire leadership style, emotional intelligence and job satisfaction has been used. The results of the research had shown that there is a positive relation between job satisfaction and emotional intelligence with leadership style (=001/0p). It can be said that a successful leadership style is an effective factor in job satisfaction of lifeguard staff of the country and high emotional intelligence can make an effective leadership style in lifeguard staff that can improve job satisfaction by using this kind of leadership style.
Functional connectomics to study Autism Spectrum Disorder

Autism Spectrum Disorder (ASD) is a clinical umbrella term for neuro-developmental disorders that are characterized by atypical social behavior, including deficits in receptive and expressive language, theory of mind (TOM), and cognitive flexibility deficit. It encompasses autism, Asperger’s syndrome, pervasive developmental disorder not otherwise specified (PDD-NOS), and childhood dis-integrative disorder. Accumulating evidence indicates that ASD is associated with alterations of neural circuitry compared to typically developing (TD) individuals. Despite numerous studies, there is a lack of consensus on the nature of atypical functional connectivity in ASD. We hypothesize that studying the effects of age, disease and their interaction together using resting-state functional MRI (rs-fMRI) data can reveal crucial insights about the autistic brain. fMRI measures blood oxygen level dependent (BOLD) signals that indirectly maps the neuronal activity across different regions of the brain. In this thesis, we studied these effects using two paradigms: Firstly, we studied the effects of age, disease and their interaction on static functional connectivity by treating the brain as a complex graph in children and adolescents (9-16 years). Graph-theoretic analyses were performed on the functional brain network. We characterized the regions of interest (ROIs), connections and functional networks that are altered in development and in ASD. The multiple network measures representing the modular organization (integration and segregation) in the whole-brain were quantified. The results showed that ASD exhibits increased functional integration at the expense of decreased functional segregation. In ASD adolescents, there is significant decrease in modularity suggesting a less robust modular organization and an increase in participation coefficient suggesting more random integration and widely distributed connection edges. There is significant hypo-connectivity observed in the adolescent group especially in the Default Mode Network (DMN) while the children group shows both hyperand hypo-connectivity. This lends support to a model of global atypical connections and further identifies functional networks and regions that are independently affected by age, disease and their interaction. Secondly, we have also explored flexibility of the brain as a novel approach to characterize ASD using the temporal dynamics of BOLD signals. The dynamic variability in the connection strength and the modular organization in terms of the measures flexiblity, cohesion strength and disjointness were explored for each subject to characterize the effects of age, disease and their interaction. In ASD, we observed significantly higher inter-subject dynamic variability in connection strength as compared to TD. This hyper-variability relates to the symptom severity in ASD. We found that the whole-brain flex-
Temperature Measurement Using Optical Fiber Methods: Overview and Evaluation

The paper deals with the overview of fiber optic methods suitable for temperature measurement and monitoring. The aim is to evaluate the current research of temperature measurements in the interval from temperature close to 0 up to 1000°C. Since the measuring chain is a functional combination of optical methods, optical fiber properties, and other photonic elements together with control electronic circuits, it is necessary to find a suitable compromise between the chosen measurement method, measuring range, accuracy, and resolution. Optical fiber sensors can be used in cases where standard electrical measurement methods cannot be used. These may be areas with high electrical and magnetic interference or critical areas. Therefore, there is intensive development of optical and fiber optic methods based on blackbody and greybody radiation, luminescence, fiber Bragg gratings (FBGs), and interferometers.