Miracle-dz/UniFAR-FTUs huggingface dataset:
Interior Moisture Design Loads for Residences

This paper outlines a methodology to obtain design values for indoor boundary conditions for moisture design calculations for residences. This is part of a larger effort by ASHRAE Standard Project Committee 160P, Design Criteria for Moisture Control in Buildings, to formulate criteria for moisture design loads, analysis techniques, and material and building performance. The standard is being developed to provide a consistent framework for moisture analysis and design. The assumptions for boundary conditions can have a large influence on the results of the moisture design analysis of a building, and the choice of boundary conditions may be the most important determinant for design recommendations based on the analysis. This paper focuses on interior moisture design loads for residences and proposes a procedure to estimate the design indoor humidity for both winter and summer conditions. The interior humidity is a function of moisture release, ventilation, dehumidification, and moisture storage in the materials in the building. If the home is not air conditioned or dehumidified, the weekly or monthly average design indoor humidity can be calculated from design ventilation and moisture release. In an air-conditioned home, the situation is more complex. It is difficult to quantify the dehumidification of an air-conditioning system typically controlled by indoor temperature rather than moisture because the cycling frequency of the air-conditioning equipment affects its ability to remove moisture. Although the specific data required for sophisticated calculations that account for changes in moisture removal due to system cycling are not available, this paper will discuss the issues involved and describe simplified alternative approaches.
Caswell, Glenys and Pollock, Kristian and Harwood, Rowan and Porock, Davina (2015) Communication between family carers and health professionals about end-of-life care for older people in the acute hospital

Background: This paper focuses on communication between hospital staff and family carers of patients dying on acute hospital wards, with an emphasis on the family carers’ perspective. The age at which people in the UK die is increasing and many continue to die in the acute hospital setting. Concerns have been expressed about poor quality end of life care in hospitals, in particular regarding communication between staff and relatives. This research aimed to understand the factors and processes which affect the quality of care provided to frail older people who are dying in hospital and their family carers. Methods: The study used mixed qualitative methods, involving non-participant observation, semi-structured interviews and a review of case notes. Four acute wards in an English University teaching hospital formed the setting: an admissions unit, two health care of older people wards and a specialist medical and mental health unit for older people. Thirty-two members of staff took part in interviews, five members of the palliative care team participated in a focus group and 13 bereaved family carers were interviewed. In all, 245 hours of observation were carried out including all days of the week and all hours of the day. Forty-two individual patient cases were constructed where the patient had died on the wards during the course of the study. Thirty three cases included direct observations of patient care. Interviews were completed with 12 bereaved family carers of ten patient cases. Results: Carers’ experience of the end of life care of their relative was enhanced when mutual understanding was achieved with healthcare professionals. However, some carers reported communication to be ineffective. They felt unsure about what was happening with their relative and were distressed by the experience of their relative’s end of life care. Conclusions: Establishing a concordant relationship, based on negotiated understanding of shared perspectives, can help to improve communication between healthcare professionals and family carers of their patients.
Self-Management Among Adults with Chronic Low Back Pain: A Causal Model

Chronic low back pain is a common musculoskeletal problem and requires self-management among adults to carry out an active and emotionally satisfying life. To support self-management, it is necessary to understand how various factors work to influence this. The objective of this study was to develop a causal model of self-management among adults with chronic low back pain. A total of 174 Thai adults with chronic low back pain aged between 30 60 years were randomly selected by a multi-stage sampling method from four hospitals in the northern region of Thailand. Data were collected via the following instruments: The Demographic Data Form, Self-Management Scale, Modified Self-Efficacy for Chronic Low Back Pain Management Scale, Low Back Pain Knowledge Questionnaire, Modified Barthel’s Activity of Daily Living Index, Chula Activity of Daily Living Index, Social Support Questionnaire, and Belief in Treatment Effectiveness Scale. Data were analyzed by descriptive statistics, Pearson’s product moment correlation, and path analysis. The results revealed that overall self-management was at a moderate level. A causal model of self-management fitted with data, and was able to explain 33.00% of the variance in self-management by four factors. These factors, self-efficacy, social support, low back pain knowledge, and belief in treatment effectiveness directly affected self-management. Social support both directly and indirectly affected self-management through self-efficacy and belief in treatment effectiveness. These results indicate that nurses can use the four factors to conduct appropriate interventions for promoting self-management among adults with chronic low back pain. Pacific Rim Int J Nurs Res 2018; 22(3) 223-236
Invalidity of the Standard Locality Condition for Hidden-Variable Models of EPR-Bohm Experiments

John Bell and others used a locality condition to establish inequalities that they believe must be satisfied by any local hidden-variable model for the spin probability distribution for two entangled particles in an EPR-Bohm experiment. We show that this condition is invalid because it contradicts the product rule of probability theory for any model that exhibits the quantum theory property of perfect correlation. This breaks the connection between Bell inequalities and the existence of any local hidden-variable model of interest. As already known, these inequalities give necessary conditions for the existence of third/fourth-order joint probability distributions for the spin outcomes from three/four separate EPR-Bohm experimental set-ups that are consistent with the second-order joint spin distributions for each experiment after marginalization. If a Bell inequality is violated, as quantum mechanics theory predicts and experiments show can happen, then at least one third-order joint probability is negative. However, this does not imply anything about the existence of local hidden-variable models for the second-order joint probability distributions for the spin outcomes of a single experiment. The locality condition does seem reasonable under the widely-applied frequentist interpretation of the spin probability distributions that views them as real properties of a random process that are manifested through their relative frequency of occurrence, which gives conditioning in the probabilities for the spin outcomes a causal role. In contrast, under the Bayesian interpretation of probability, probabilistic conditioning on one particle’s spin outcome in the product rule is viewed as information to make probabilistic predictions of the other particle’s spin outcome. There is nothing causal and so no reason to develop International Journal of Quantum Foundations 5 (2019) 116 a locality condition. Thus, how probability is to be interpreted is critical to understanding quantum entanglement and locality.
The peri-procedural management of new oral anti-coagulants (NOACs) in interventional electrophysiology

Because of their rapid onset of action and short therapeutic half-life, new oral anticoagulants (NOACs) may significantly simplify peri-procedural oral anti-coagulation management during cardiac implantable electronic device implant and trancatheter ablation procedures. The pharmacological properties of NOACs are reviewed to better comprehend how these drugs may best be managed in the setting of different electrophysiological procedures. These drugs radically differ from conventional vitamin K antagonists, but also possess distinctive pharmacokinetics and pharmacodynamics that distinguish one NOAC from the other. Clinical evidence on the use of NOACs during CIED implant and transcatheter ablation procedures is still limited, but, at the same time, is rapidly expanding; there is a great need for extensive data derived from randomized-controlled trials and multicentre registries to better define the use of these drugs in interventional electrophysiology.
A study on metabolic syndrome in patients with Psoriasis

Objectives  To study the association of psoriasis and metabolic syndrome.  To evaluate the disease activity and duration in psoriatic patients with and without metabolic syndrome. Materials and Method: The study was conducted at MVJ Medical College, Hoskote, Bangalore. 100 newly diagnosed psoriasis patients who had not received systemic treatment 1 month before enrollment were included in study. A complete lipid profile with fasting blood glucose levels were estimated together with measurement of blood pressure and central obesity. Serum lipids were measured and fasting glucose was analysed. Results: Among the 100 patients studied, a majority of patients were male (56%), while female patients accounted for 44%. 37 out of 100 patients had metabolic syndrome. Impaired HDL levels and fasting triglyceride were the most commonly affected components of metabolic syndrome affecting 59% and 54% respectively. There was a direct relationship between the occurrence of metabolic syndrome and extent of body surface area involved by psoriasis. Patients with psoriasis for more than 73 months had a higher occurrence of metabolic syndrome (37.84%). There was no significant correlation between PASI score and metabolic syndrome. Interpretation and Conclusion: Our study correlated with the various Indian and western studies proving an association between psoriasis and metabolic syndrome. This has important implication in aiding the dermatologist to tackle issue of metabolic syndrome in psoriatic patients and in the process prevent the cardiovascular complication that are anticipated.
A STUDY TO ASSESS THE LEVEL OF LIPID PROFILE AND SERUM LIPOPROTEIN (A) IN POLYCYSTIC OVARIAN SYNDROME WHILE COMPARING CLINICAL OUTCOMES OF CASES AND CONTROLS

Objective: The research objective was to assess the level of lipid profile and serum lipoprotein (a) in polycystic ovarian syndrome while dividing the research sample into cases and controls. Methodology: The study started from May 2017 and completed in December 2017 at the Department of Obstetrics and Gynecology of Services Hospital, Lahore. This study included at its best PCOS of 30 cases along with 30 controls. A comparison was made of Lp(a) and Lipid profile among all these cases along with controls and their findings were recorded on an already determined proforma. Result: TG, TC/HDL, LDL, LDL/HDL, VLDL and Serum TC quantities were elevated in all cases. As opposed to the controls, the cases of Lp(a) levels greater than 30 mg/dl were present more in the cases. Conclusion: Elevated Lp(a) and Dyslipidemia, for the patients of PCOS, may become a greater danger of becoming coronary artery disease.
Unwinding and annealing by reverse gyrase

Background: The thermophilic DNA topoisomerase reverse gyrase induces DNA positive supercoiling. Results: The novel reverse gyrase, PcalRG, is presented. Conclusion: PcalRG is the most efficient and robust reverse gyrase known, and the first inducing ATP-dependent unwinding of Holliday junctions and annealing of single-stranded oligonucleotides. Significance: PcalRG shares structural and functional features with evolutionary conserved helicase-topoisomerase complexes involved in genome stability.
CCIDE_A_345367 541..552

1Department of Prosthodontics, Faculty of Dentistry, Ege University, Bornova, İzmir, Turkey; 2Department of Endodontics, Faculty of Dentistry, Ege University, Bornova, İzmir, Turkey; 3Ministry of Health, Demirköprü Oral & Dental Health Center, İzmir, Turkey Purpose: A treatment protocol involving the root canal treatment with conventional palatal access cavity and the partial veneer application may considerably reduce the fracture resistance of the teeth. On the other hand, labial access cavity within the partial veneer outlines followed with the partial veneer application may more successfully recover the lost fracture resistance of the endodontically treated teeth. In this regard, the present study aims to compare the fracture resistances of upper central incisors endodontically treated with palatal and labial accesses and restored with restorative resin composite and lithium disilicate partial veneers. Materials and Methods: Three groups consisting ten specimens each were prepared by using extracted sound human upper central incisors. Root canal treatments with palatal access, resin composite restoration of the access cavities and veneer restorations were applied to the first group (Group P). Root canal treatments with labial access, resin composite restoration of the access cavities and veneer restorations was applied to the second group (Group L). Veneer restorations were applied to the third group (Group C) without root canal treatment. Specimens were thermocycled and loaded to fracture in order to record their fracture resistances. Results: The mean fracture resistance of Group C was observed to be significantly higher, compared to Groups P and L (P < 0.05). Fracture resistance of Group L was observed to be higher, compared to Group P, but the difference was not found statistically significant. Light microscope revealed that the specimens fractured in five different modes. Conclusion: Although the mean fracture resistance of the teeth that endodontically treated with labial access cavity prior to the ceramic partial veneer application was higher in comparison with the teeth that endodontically treated with palatal access cavity prior to the ceramic partial veneer application, the difference was found statistically insignificant (P < 0.05).
Highly cold-active pectinases under wine-like conditions from non-Saccharomyces yeasts for enzymatic production during winemaking

Significance and Impact of the Study: Nowadays, there is increasing interest in low-temperature winemaking. Nevertheless, commercial oenological pectinases, produced by fungi, are rarely active at low temperatures. Cold-active pectinases that are stable under vinification conditions are needed. This study indicated that cold-active and acid-tolerant pectinases from non-Saccharomcyes yeasts were able to remain active at glucose, ethanol and SO2 concentrations usually found in winemaking. Furthermore, not only are these yeasts a source of cold-active pectinases, but the yeasts themselves are also potential adjunct cultures for oenology to produce these enzymes during cold-winemaking.
-glutathionylation of metallothioneins by nitrosative/oxidative stress

Cystein residues within metallothionein (MT) structure have been shown to be particularly prone to S -nitrosylation. The objective of this study was to examine the possibility that MTs undergo S -glutathionylation under nitrosative/oxidative stress. MT from rabbit liver was treated with different concentrations of GSNO, diamide plus GSH or H 2 O 2 plus GSH. Parallel sets of samples were treated with 10 mM DTT for 30 min at 37°C to reduce mixed disulphides. Incubations were then processed for Western blot or dot-immunobinding assay. Western blot with anti-MT or anti-GSH were also performed on peripheral blood mononuclear cell extracts. Structural aspects of S -glutathionylation of MTs were also examined. Treatment with GSNO, diamide/GSH or H 2 O 2 /GSH induced a dose-dependent increase in the levels of MT S -glutathionylation. This effect was completely reversed by treatment with the reducing agent DTT, indicating that S -glutathionylation of MT protein was related to formation of protein-mixed disulphides. Structural analysis of rat MT indicated that Cys residues located in the N-terminal domain of the protein are the likely targets for S -glutathionylation, both for their solvent accessibility and electrostatics induced reactivity. S -glutathionylation of MT, given its reversibility, would provide protection from irreversible oxidation of Cys residues, thus representing a mechanism of high potential biological relevance.
Metabolomedynamic responsesofSaccharomyces cerevisiae to simultaneous rapid perturbations in external electronacceptorand electrondonor

Rapid perturbation experiments are highly relevant to elaborate the in vivo kinetics for mathematical models of metabolism, which are needed for selecting gene targets for metabolic engineering. Perturbations were applied to chemostatcultivated biomass (D = 0.05 h , aerobic glucose/ethanol-limited) using the BioScope of Saccharomyces cerevisiae CEN. PK 113-7D over time span of 90 and 180 s. The availability of the external electron acceptor oxygen was decreased from fully aerobic to anaerobic conditions. It was observed that the changes in metabolome response under these conditions were limited to the pyruvate node. Acetaldehyde supply was used as an extra external electron acceptor during glucose perturbation under fully aerobic conditions. This had a strong effect on the metabolome dynamics and resulted in a significantly higher initial glycolytic flux. Dynamic response of the adenine nucleotides indicated that their behavior is not dictated by the glycolytic flux but is much more coupled to the cytosolic NADH/ NAD ratio through the equilibrium pool of fructose 1,6-bisphosphate and 2/3phosphoglycerate. Also, the electron donor availability (glucose) was decreased. This did not result in significant changes in the concentrations of the glycolytic and tricarboxylic acid cycle metabolites, whereas the adenine nucleotides, especially ADP and AMP, showed the opposite response to that observed in a glucose pulse experiment. Surprisingly, trehalose was not mobilized in the time frame of 180 s.
Induced by TCR Antagonists The Src Family Kinase Fyn Mediates Signals

FcR nonbinding anti-CD3 (cid:1) mAbs elicit partial TCR signaling that leads to T cell unresponsiveness and tolerance in vivo. In this study, the membrane-proximal events that promote T cell inactivation by FcR nonbinding anti-CD3 mAbs were examined. In the context of FcR nonbinding anti-CD3, TCR complexes did not aggregate and failed to translocate into glycolipid-enriched membrane microdomains. Furthermore, FcR nonbinding anti-CD3 mAbs induced tyrosine phosphorylation of the Fyn substrate Cbl, but not the ZAP-70 substrate linker for activation of T cells. Overexpression of Fyn, but not Lck, restored the mitogenicity of FcR nonbinding anti-CD3 in primary T cells. Taken together, these results suggest that Fyn mediates the partial signaling induced by TCR antagonists. The Journal of Immunology, 2002, 168: 4480–4487. ctivation of T cells requires multivalent engagement and aggregation of the TCR/CD3 complex. Under physio-logical conditions, this is accomplished by multivalent interactions of the TCR with MHC/peptide complexes expressed on APCs. These conditions can be mimicked by anti-TCR/CD3 mAbs that mediate cross-linking of the TCR at the interface of FcR-bearing cells. TCR cross-linking leads to a cascade of intracellular biochemical events that promote cell division and cytokine production.Invitro,bivalent, FcR nonbinding forms of anti-CD3 mAbs fail to TCR aggregation or activate naive and primary cells. The altered anti-CD3 mAbs unresponsiveness of proin-ﬂammatory Th1 cells and deviation of undifferentiated T cells an Th2 (1–3). ﬁndings,
Neutrophil – lymphocyte ratio dynamics are useful for distinguishing between recurrence and pseudoprogression in high-grade gliomas

Objective: Distinguishing recurrence and pseudoprogression is a major challenge in the clinical practice of treatment for high-grade gliomas (HGGs). The neutrophil – lymphocyte ratio (NLR) has been reported to be closely related to survival in HGGs. We aimed to assess the predictive value of NLR in the differential diagnosis of recurrence and pseudoprogression. Materials and Methods: A total of 135 patients with histologically con ﬁ rmed HGGs were studied. All patients underwent focal radiotherapy and concomitant temozolomide (TMZ), followed by 6 cycles of TMZ if MRI showed no progressive enlargement of contrast-enhancing lesions. MRI evaluation was taken 4 weeks after concurrent chemoradiotherapy and then every 2 months later. NLR was calculated at 4 time points of preoperation, before concurrent RT-TMZ (pretreatment), 4 weeks following completion of RT-TMZ, and MRI showed lesion enlarged or treatment completed. Results: In 135 patients, 47 (34.8%) were found to be pseudoprogression (PsPD), and 28 (20.7%) were early disease progression (ePD). The mean pretreatment and post-treatment NLR were 4.2±2.1 and 5.1±3.5, respectively. The median overall survival in the PsPD group (25.2 months) was signi ﬁ cantly longer than in the ePD (15.4 months) and no progression group (nPD) (21.6 months) ( p <0.001). Overall survival was signi ﬁ cantly shorter in the baseline NLR ≥ 4 cohort compared with NLR<4 ( p =0.03), but no signi ﬁ cant difference was found between PsPD and ePD (p=0.197). Patients with decreased NLR showed signi ﬁ cantly longer survival than no decreased group ( p <0.001), and decreased NLR was found to be a signi ﬁ cant difference between PsPD and ePD ( p =0.022). Univariate and multivariate logistic regression analyses suggested that decreased NLR was an independent prognosis factor ( p =0.031). Conclusion: Decreased NLR is an independent prognostic factor and is useful for distinguishing between recurrence and pseudoprogression in HGGs.