Miracle-dz/UniFAR-FTUs huggingface dataset:
Design and fabrication of a fish feed mixing cum pelleting machine for small-medium scale aquaculture industry

Abstract The study developed a compact, single unit of fish feed mixing and pelleting machine. In this work, a compact fish feed mixing and pelleting machine was designed, fabricated, and evaluated for its performance efficiency. The basic units of the machine are the processing unit, structural support, and the prime mover. The major component of the feed substrates used were maize, fish meal, soya bean cake, blood, and bone meal in their varied proportions blended with wet cassava starch to establish the machine performance and efficiency. The results showed that the varied proportions of starch inclusion in the blended substrate have influence on the investigated machine performance parameters. The performance outputs from the machine revealed the highest pelleting efficiency of 80.36%, pellet durability of 98.74%, throughput capacity of 4.16 kg/h, and the least labour requirement of 0.23 man-hour per kg at a starch inclusion of 0.125 kg, while the highest pellet bulk density of 0.302 g/cm3 was recorded at 0.20 and 0.125 kg starch addition. Machine economic analysis revealed that it can be of benefit for small- to medium-scale fish feed farmers.
Thrombospondin-1 promotes fibro-adipogenic stromal expansion and contractile dysfunction of the diaphragm in obesity

Pulmonary disorders impact 40-80% of individuals with obesity. Respiratory muscle dysfunction is linked to these conditions; however, its pathophysiology remains largely undefined. Mice subjected to diet-induced obesity (DIO) develop diaphragmatic weakness. Increased intra-diaphragmatic adiposity and extracellular matrix (ECM) content correlate with reductions in contractile force. Thrombospondin-1 (THBS1) is an obesity-associated matricellular protein linked with muscular damage in genetic myopathies. THBS1 induces proliferation of fibro-adipogenic progenitors (FAPs)—mesenchymal cells that differentiate into adipocytes and fibroblasts. We hypothesized that THBS1 drives FAP-mediated diaphragm remodeling and contractile dysfunction in DIO. We tested this by comparing effects of dietary challenge on diaphragms of wild-type (WT) and Thbs1 knockout (Thbs1-/-) mice. Bulk and single-cell transcriptomics demonstrated DIO-induced stromal expansion in WT diaphragms. Diaphragm FAPs displayed upregulation of ECM and TGFβ-related expression signatures, and augmentation of a Thy1-expressing sub-population previously linked to type 2 diabetes. Despite similar weight gain, Thbs1-/- mice were protected from these transcriptomic changes, and from obesity-induced increases in diaphragm adiposity and ECM deposition. Unlike WT controls, Thbs1-/-diaphragms maintained normal contractile force and motion after DIO challenge. These findings establish THBS1 as a necessary mediator of diaphragm stromal remodeling and contractile dysfunction in overnutrition, and potential therapeutic target in obesity-associated respiratory dysfunction.
All-night spectral and microstate EEG analysis in patients with recurrent isolated sleep paralysis

The pathophysiology of recurrent isolated sleep paralysis (RISP) has yet to be fully clarified. Very little research has been performed on electroencephalographic (EEG) signatures outside RISP episodes. This study aimed to investigate whether sleep is disturbed even without the occurrence of a RISP episode and in a stage different than conventional REM sleep. 17 RISP patients and 17 control subjects underwent two consecutive full-night video-polysomnography recordings. Spectral analysis was performed on all sleep stages in the delta, theta, and alpha band. EEG microstate (MS) analysis was performed on the NREM 3 phase due to the overall high correlation of subject template maps with canonical templates. Spectral analysis showed a significantly higher power of theta band activity in REM and NREM 2 sleep stages in RISP patients. The observed rise was also apparent in other sleep stages. Conversely, alpha power showed a downward trend in RISP patients’ deep sleep. MS maps similar to canonical topographies were obtained indicating the preservation of prototypical EEG generators in RISP patients. RISP patients showed significant differences in the temporal dynamics of MS, expressed by different transitions between MS C and D and between MS A and B. Both spectral analysis and MS characteristics showed abnormalities in the sleep of non-episodic RISP subjects. Our findings suggest that in order to understand the neurobiological background of RISP, there is a need to extend the analyses beyond REM-related processes and highlight the value of EEG microstate dynamics as promising functional biomarkers of RISP. Significance Statement We focused on tracking electrophysiological traces of RISP (a REM parasomnia) beyond REM sleep of subjects clinically diagnosed with RISP outside of RISP episodes. We observed a rise of theta band activity in NREM 2 sleep of RISP patients. This may point to a larger dysregulation of sleep mechanism making the person more prone to sudden awakenings in the upcoming REM sleep. Theta band differences were further observed in REM sleep. We additionally utilized the EEG MS methodology on deep sleep to investigate differences in dominant brain topographies. Though dominant brain topographies are consistent with canonical MS, RISP patients show significantly different transitioning between sleep-related topographies suggesting a difference in their sleep regulation mechanisms.
Lineage-based scaling of germline intercellular bridges during oogenesis

The size of subcellular structures must be tightly controlled to maintain normal cell function; this is especially important when cells are part of developing tissues or organs. Despite its importance, few studies have determined how the size of organelles or other structures is maintained during tissue growth, when cells are growing, dividing, and rearranging. The developing egg chamber is a powerful model in which to study the relative growth rates of subcellular structures. The egg chamber contains a cluster of sixteen germ cells, which are connected through intercellular bridges called ring canals. Ring canals are formed following incomplete cytokinesis after each of four germ cell divisions. As the egg chamber grows, the nurse cells and the ring canals that connect them increase in size. Here, we demonstrate that ring canal size scaling is related to their lineage; the largest, “first born” ring canals grow at a relatively slower rate than ring canals derived from subsequent mitotic divisions. This lineage-based scaling relationship is maintained even if directed transport is reduced, ring canal size is altered, or if the germ cells go through an additional mitotic division. Further, we propose that changes in ring canal scaling could provide a mechanism to alter egg size.
The effects of skin tone on photoacoustic imaging and oximetry

Significance Photoacoustic imaging (PAI) provides contrast based on the concentration of optical absorbers in tissue, enabling the assessment of functional physiological parameters such as blood oxygen saturation (sO2). Recent evidence suggests that variation in melanin levels in the epidermis leads to measurement biases in optical technologies, which could potentially limit the application of these biomarkers in diverse populations. Aim To examine the effects of skin melanin pigmentation on photoacoustic imaging and oximetry. Approach We evaluated the effects of skin tone in PAI using a computational skin model, two-layer melanin-containing tissue-mimicking phantoms, and mice of a consistent genetic background with varying pigmentations. The computational skin model was validated by simulating the diffuse reflectance spectrum using the adding-doubling method, allowing us to assign our simulation parameters to approximate Fitzpatrick skin types. Monte Carlo simulations and acoustic simulations were run to obtain idealised photoacoustic images of our skin model. Photoacoustic images of the phantoms and mice were acquired using a commercial instrument. Reconstructed images were processed with linear spectral unmixing to estimate blood oxygenation. Linear unmixing results were compared with a learned unmixing approach based on gradient-boosted regression. Results Our computational skin model was consistent with representative literature for in vivo skin reflectance measurements. We observed consistent spectral colouring effects across all model systems, with an overestimation of sO2 and more image artefacts observed with increasing melanin concentration. The learned unmixing approach reduced the measurement bias, but predictions made at lower blood sO2 still suffered from a skin tone-dependent effect. Conclusion PAI demonstrates measurement bias, including an overestimation of blood sO2, in higher Fitzpatrick skin types. Future research should aim to characterise this effect in humans to ensure equitable application of the technology.
A tryptophan metabolite modulates the host response to bacterial infection via kainate receptors

Bacterial infection involves a complex interaction between the pathogen and host where the outcome of infection is not solely determined by pathogen eradication. To identify small molecules that promote host survival by altering the host-pathogen dynamic, we conducted an in vivo chemical screen using zebrafish embryos and found that treatment with 3-hydroxy-kynurenine protects from lethal gram-negative bacterial infection. 3-hydroxy-kynurenine, a metabolite produced through host tryptophan metabolism, has no direct antibacterial activity but enhances host survival by restricting bacterial expansion in macrophages by targeting kainate-sensitive glutamate receptors. These findings reveal new mechanisms by which tryptophan metabolism and kainate-sensitive glutamate receptors function and interact to modulate immunity, with significant implications for the coordination between the immune and nervous systems in pathological conditions.
Simultaneous optogenetic manipulation and calcium imaging in freely moving C . elegans

Simultaneous optogenetic manipulation and calcium imaging in freely moving C. elegans" (2014). This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. Understanding how an organism's nervous system transforms sensory input into behavioral outputs requires recording and manipulating its neural activity during unrestrained behavior. Here we present an instrument to simultaneously monitor and manipulate neural activity while observing behavior in a freely moving animal, the nematode Caenorhabditis elegans. Neural activity is recorded optically from cells expressing a calcium indicator, GCaMP3. Neural activity is manipulated optically by illuminating targeted neurons expressing the optogenetic protein Channelrhodopsin. Real-time computer vision software tracks the animal's behavior and identifies the location of targeted neurons in the nematode as it crawls. Patterned illumination from a DMD is used to selectively illuminate subsets of neurons for either calcium imaging or optogenetic stimulation. Real-time computer vision software constantly updates the illumination pattern in response to the worm's movement and thereby allows for independent optical recording or activation of different neurons in the worm as it moves freely. We use the instrument to directly observe the relationship between sensory neuron activation, interneuron dynamics and locomotion in the worm's mechanosensory circuit. We record and compare calcium transients in the backward locomotion command interneurons AVA, in response to optical activation of the anterior mechanosensory neurons ALM, AVM or both.
Comparison of transthoracic ultrasonography, computer-assisted lung auscultation, and transtracheal wash cytology in stocker cattle with bovine respiratory disease

Field methods to diagnose bovine respiratory disease (BRD) do not accurately identify airway inflammation and lack clinical sensitivity. New diagnostic modalities, such as thoracic ultrasound (TU), computer-assisted lung auscultation (CALA), and transtracheal wash (TTW), have recently emerged which may deliver accurate diagnosis and prediction of BRD in clinical settings. Therefore, we sought to compare TU, CALA, and TTW fluid cytologic assessment in stocker cattle at risk for BRD in a pilot study. We enrolled 17 high-risk mixed-breed beef steers, sampled 10 and 21 days after arrival and conventional management, in a pilot cross-sectional observational study. Cattle were examined daily for 82 days for clinical BRD. On day 10, 16 cattle received CALA, and 10 and 8 of these received TU and TTW, respectively. On day 21, 12 cattle received CALA and TTW, and 10 received TU. CALA was scored as 1-5. Lung consolidation and/or comet tails were evaluated by TU. TTW was evaluated by 200-cell differential count, with inflammation defined as >20% neutrophils. Relationships between each diagnostic test, and between diagnostic tests and clinical BRD, were evaluated by logistic regression (P<0.10). Fourteen cattle were treated for BRD. CALA scores ranged 1-3; three cattle had lung consolidation. On day 10, 5 of 6 cattle previously treated for BRD and 0 of 3 not treated had >20% TTW neutrophils. On day 21, 5 of 9 treated cattle and 1 of 3 not treated had >20% TTW neutrophils. No significant relationship between CALA, TU, and TTW inflammation existed. TTW inflammation was associated with BRD diagnosis (P=0.0586). CALA and TU results were unrelated to TTW inflammation. Cytologic assessment of TTW may improve antemortem diagnosis of BRD.
Fishes from the Kashmir Valley

In March-April 1954 the late Dr. Sunder Lal Hora visited the Kashmir Valley and made an extensive collection of fishes, which on his return to Calcutta he kindly passed on to me for study. As regards the topography of the Kashmir Valley and its drainage, he wrote that the Valley is ' about eighty miles long, about twenty to twenty-five miles broad, and on the average rising about 6000 ft. above sea-level.
A Prey-Predator Defence Mechanism For Ad Hoc On-Demand Distance Vector Routing Protocol

This study proposes a nature-based system survivability model. The model was simulated, and its performance was evaluated for the mobile ad hoc wireless networks. The survivability model was used to enable mobile wireless distributed systems to keep on delivering packets during their stated missions in a timely manner in the presence of attacks. A prey-predator communal defence algorithm was developed and fused with the Ad hoc On-demand Distance Vector (AODV) protocol. The mathematical equations for the proposed model were formulated using the Lotka-Volterra theory of ecology. The model deployed a security mechanism for intrusion detection in three vulnerable sections of the AODV protocol. The model simulation was performed using MATLAB for the mathematical model evaluation and using OMNET++ for protocol performance testing. The MATLAB simulation results, which used empirical and field data, have established that the adapted Lotka-Volterra-based equations adequately represent network defense using the communal algorithm. Using the number of active nodes as a measure of throughput after attack (with a maximum throughput of 250 units), the proposed model had a throughput of 230 units while under attack and the intrusion was nullified within 2 seconds. The OMNET++ results for protocol simulation that use throughput, delivery ratio, network delay, and load as performance metrics with the OMNET++ embedded datasets showed good performance of the model, which was better than the existing conventional survivability systems. The comparison of the proposed model with the existing model is also presented. The study concludes that the proposed communal defence model was effective in protecting the entire routing layer (layer 2) of the AODV protocol when exposed to diverse forms of intrusion attacks.
Prevalence of Overweight and Obesity in Collegiate American Football Players, by Position

Objective: The authors' purpose in this study was to determine overweight and obesity prevalence in a collegiate football team. Participants: Eighty-five National Collegiate Athletic Association (NCAA) Division I football players volunteered to participate. Methods: The authors measured height, weight, and waist circumference (WC), and estimated body fat percentage (% BF) from bioelectrical impedance. Results: Body mass index (BMI), WC, and % BF were all positively correlated (p < .01), but BMI overestimated the prevalence of overweight and obesity in 50.6% of the cases. Fourteen players (16%) qualified as obese under all 3 methods. Offensive linemen had significantly higher % BF (p < .01) than most other positions, and on average this group exceeded the at-risk criteria for BMI (> 30 kg/m2), WC (> 102 cm), and % BF (> 25%). Conclusions: BMI alone is not a valid indicator of overweight and obesity in a strength-trained athletic population. However, some collegiate football players, especially linemen, meet multiple criteria for obesity.
Crystal Size and Orientation Patterns in the Wisconsin-Age Ice from Dye 3, Greenland

Crystal size and c-axis orientation patterns were measured on the Dye 3, Greenland, deep ice core in order to investigate time-dependent changes or alterations in the physical character of the core as a function of time after recovery. The physical measurements were expanded to include depth intervals not previously studied in the field. The recent study focused on core samples located between 1786 m and the bottom of the ice sheet at 2037 m. Manual c-axis measurements were made on 23 new thin sections using a Rigsby-type universal stage. A new semi-automatic ultrasonic wave-velocity measuring device was developed in order to compare the results with the earlier manual measurements and to study an additional 114 ice-core samples in the Wisconsin-age ice. Crystal-size measurements were made on specimen surfaces by inducing evaporation grooves at crystal boundaries and measuring linear intercepts. The ultrasonically measured test samples were subsequently cleaned and analyzed by ion chromatography in order to measure impurity concentration levels of Cl−, NO3− and SO4 2− and study their effects on crystal growth and c-axis orientation.
Friendship and Organizational Analysis

Recent developments in organizational analysis have done much to fill out the dry, textbook image of rational, formal structures. Yet on one of the commonest kinds of organizational experience—friendship—organizational analysis has remained virtually silent. By contrast, within the wider social science literature some writers have recently accorded greater importance to friendship as a social phenomenon. This article suggests that organizational analysis would be well served by doing the same. To this end, the article explores what this might entail and identifies some of the issues that it could illuminate, both empirically and theoretically. In particular, it presents friendship as a folk concept, which recognizes the situational variability of its form, experience, and connectedness with other forms of relationship. In doing so, the article will help define and open up a focus for future research into friendship and organizational analysis.
Innovations in Pharmaceutical Industry Spin-off and Innovation in the Pharmaceutical Industry Regular Paper

Parent companies usually undertake corporate spin-offs to cope with higher competitive environments or when, in high technology industries, the differences between R&D investments and intangible assets are larger. Consistent with the recent “positive view”, spinoffs can be considered as a “proactive strategic choice” to foster innovation, develop new activities, being different from past strategic initiatives and, more generally, not being strictly connected to the corporate strategy of the firm. In order to investigate the relation between divestiture decisions and innovation, we conduct an explorative case study in the pharmaceutical industry to show how spin-offs can help firms to explore new opportunities for innovation, search for new funding and push to create the basis for future development.
Perceptions of the impact of mobile phone use for social networking in Malaysia among university students of East African origin

PERCEPTIONS OF THE IMPACT OF MOBILE PHONE USE FOR SOCIAL NETWORKING IN MALAYSIA AMONG UNIVERSITY STUDENTS OF EAST AFRICAN ORIGIN Judith Flora Etabale Wanda Malaysian universities and colleges are currently attracting international students in need of higher education and in crossing national borders for their education these international students have to leave their family and social networks in their country of origin. With the current development in technology mobile phones have become progressively more popular as they are one of the frequently used means of communication that people rely on to communicate often because of its features. While people find mobile phones convenient and useful, international students in foreign countries tend to appreciate them more and be more dependent on them in order to maintain their social networks. Based on a survey conducted in various private universities in the Klang Valley where foreign students of East African origin are studying, students’ mobile phone use for social networking was examined. The results also showed that there was a positive significant relationship between variables such as interaction, interpersonal communication and social networking for academic purpose, however there is no significance difference in mobile phone dependency for social networking among University students of East African origin in Malaysia.
Holocene Sea-Level Change on Aitutaki, Cook Islands: Landscape Change and Human Response

Holocene sea-level changes profoundly affected the Pacific's human populations in the prehistoric past. Geoarchaeological studies on Aitutaki, southern Cook Islands, suggest sea-level fall coincident with the period of human occupation. The coastal beach barrier which formed along Aitutaki's central western coast after sea-level fall became the focus of human habitation over the last millennium. Faunal and floral assemblages from the earliest in-situ cultural occupation on the island demonstrate significant anthropogenic influences on the environment at 1000 BP, suggesting human colonisation occurred at an earlier, but as yet undetermined, date. Failure to unearth direct evidence of colonising settlements may in part be the consequence of a more exposed coastline prior to the Holocene sea-level fall.
The Othering of Islam in a European Context

Abstract Media representations of Islam mostly appear in the Finnish media in connection with events in other parts of the world. In this context, Islam is often treated as something distant and ascribed the role of the Other. These representations function as definers for collective categorizations, having an impact on which categories for self-identifications are relevant in specific cases. The aim of the present article is to discuss othering discourses on Islam in Swedish-language dailies in Finland on the basis of the debate following the cartoons of the Prophet Muhammad. These discourses build upon a broader tradition of othering and have a great deal in common with medieval representations, thus the othering of Islam in a historical perspective is also briefly discussed.