Miracle-dz/UniFAR-FTUs huggingface dataset:
Treatment of patients with psoriasis resulting from a review of previously unmet needs, with particular reference to the new line of treatment with dimethyl fumarate (DMF): experts' recommendations

Psoriasis has a significant impact on patients’ physical and mental state. Their quality of life is often impaired. What is more, despite the involvement of a significant number and type of health care services and significant financial outlays, psoriasis patients in Poland are treated suboptimally and non-cost-effectively (large percentage – 11.1% – of hospitalizations because of psoriasis, the longest hospitalization of patients with psoriasis among other der-matological patients – 8.6 days, treatment outside their administrative region – 58.1% of hospitalized patients). Psoriasis management is based on a sequential therapy. Biological treatment is available only to a limited group of patients with the most severe disease, what indicates the desirability of widening prescription-based systemic treatments that could be used prior to biological treat-ment. This would increase the possibility of treatment in-dividualization by all dermatologists. In order to achieve optimal treatment results, patients should be offered to be treated with several treatment lines because it is not known which drug will be effective in their case. Dimeth-yl fumarate (DMF) is the one of new drugs, that meets the criteria for an additional systemic treatment option, prior to biological treatment. DMF therapy is associated with significant health benefits, which include improving the quality of life and lengthening the time with an adequate response to treatment. This therapy allows the patients to obtain greater benefits from treatment and to prolong the time without symptoms of the disease (symptoms-free).
Photoelectrons and solar ionizing radiation at Mars: Predictions versus MAVEN observations

Understanding the evolution of the Martian atmosphere requires knowledge of processes transforming solar irradiance into thermal energy well enough to model them accurately. Here we compare Martian photoelectron energy spectra measured at periapsis by Mars Atmosphere and Volatile Evolution MissioN (MAVEN) with calculations made using three photoelectron production codes and three solar irradiance models as well as modeled and measured CO2 densities. We restricted our comparisons to regions where the contribution from solar wind electrons and ions were negligible. The two intervals examined on 19 October 2014 have different observed incident solar irradiance spectra. In spite of the differences in photoionization cross sections and irradiance spectra used, we find the agreement between models to be within the combined uncertainties associated with the observations from the MAVEN neutral density, electron flux, and solar irradiance instruments.
The Dimensional Change of Resin Denture Base After Immersion of Cinnamomum burmannii Extract and Chlorhexidine Solution

Heat-cured acrylic resin is the most commonly used denture base material due to its biological, mechanical, chemical, and physical properties. Denture cleaning, which is essential for successful denture use, can be facilitated by utilizing cinnamon extract Cinnamomum burmannii 20% and chlorhexidine 0.2% as effective cleaning agents. However, these materials can affect the physical properties of denture, such as a dimensional change. The design of this study is experimental laboratories, aimed at identifying the effect of immersing denture base in extract Cinnamomum burmannii 20% and chlorhexidine 0.2% for 1 year (92 hours) to dimensional change of heat-cured acrylic resin. The sample consists of 30 heat-cured acrylic resin with sizes 65 mm x 10 mm x 2.5 mm, divided into 3 groups of treatment. After the entire study design has been carried out, data was analyzed by Univariat and one-way Anova and the result showed the significant of p = 0,001 (p<0,05). In this study, it was seen the the value of the dimensional change that was immersed in extract Cinnamomum burmannii 20% resulted in a smaller dimensional change value compared to chlorhexidine 0.2%.
An optimal data assimilation method and its application to the numerical simulation of the ocean dynamics

ABSTRACT An original data assimilation (DA) scheme with a general dynamics model is considered. It is shown that this scheme can be approximated by the stochastic diffusion process. The sufficient conditions to provide this approximation are formulated. Based on this algorithm a new DA method is developed. The method combines variational and statistical approaches commonly used in DA theory and minimizes the variance of the trajectory of a diffusion process in conjunction with a dynamics numerical model. In this sense the method is optimal in contrast to other DA approaches. The proposed scheme takes the model dynamics into account and in this way it differs from the well-known Kalman filter. Furthermore, the derived DA method can be applied to a very wide field of dynamical systems, for example, gas dynamics, fluid dynamics and other disciplines. However, the current study deals with oceanography and DA in oceanography specifically. Then the method is applied to the HYbrid Coordinate Ocean Model and assimilates satellite sea level anomaly data from the Archiving, Validating and Interpolating Satellite Oceanography Data over the Atlantic Ocean to correct the model state. Several numerical experiments have been performed. The experiments show that the method substantially changes the synoptic and mesoscale structure of ocean dynamics. Also, the distribution of the obtained result is estimated through the solution of the Fokker–Planck–Kolmogorov equation.
Long-lasting responses with chemotherapy followed by T-cell therapy in recurrent or metastatic EBV-related nasopharyngeal carcinoma

Background Refractory or metastatic nasopharyngeal carcinoma (NPC) patients have a poor prognosis due to the lack of effective salvage treatments and prolonged survival by means of combination chemotherapy being described only for a minority of younger patients with oligometastatic disease. Targeting the Epstein - Barr virus (EBV) proteins expressed in NPC cells has been shown to be a feasible strategy that could help control systemic disease. Patients and Methods Between 2011 and 2014, 16 patients with recurrent/metastatic EBV-NPC received first-line chemotherapy (CT) followed by 2 doses of autologous cytotoxic EBV specific T-lymphocytes (15-25 x 107 total cells/dose, 2 weeks apart), based on our previous studies showing the feasibility and efficacy of this infusion regimen. Cumulative overall survival (OS) and median OS were analysed in the whole population and according to specific clinical and biological parameters. Results All patients received the planned T-cell therapy schedule, 9 after reaching partial (n=5) or complete (n=4) disease remission with CT, and 7 after failing to obtain benefit from chemotherapy. No severe adverse events were recorded. Patients who received cytotoxic T-lymphocytes (CTLs) had a cumulative 10-year OS of 44%, with a median OS of 60 months (95% CI 42-62). Patients responding to CT, with oligometastatic disease (<3 disease sites), and plasma EBV-DNA <1000 copies/mL had a better outcome. Conclusions Autologous EBV-specific CTLs transplanted following conventional first-line CT demonstrated promising efficacy with several patients obtaining long-lasting disease control. The rationale provided by this study, with the crucial role likely played by the timing of CTL administration when trying to induce synergy with conventional treatment needs to be confirmed in a prospective controlled trial.
Melatonin as a Coadjuvant in the Treatment of Patients with Fibromyalgia

Fibromyalgia syndrome (FMS) is a chronic widespread pain syndrome that is accompanied by fatigue, sleep disturbances, anxiety, depression, lack of concentration, and neurocognitive impairment. As the currently available drugs are not completely successful against these symptoms and frequently have several side effects, many scientists have taken on the task of looking for nonpharmacological remedies. Many of the FMS-related symptoms have been suggested to be associated with an altered pattern of endogenous melatonin. Melatonin is involved in the regulation of several physiological processes, including circadian rhythms, pain, mood, and oxidative as well as immunomodulatory balance. Preliminary clinical studies have propounded that the administration of different doses of melatonin to patients with FMS can reduce pain levels and ameliorate mood and sleep disturbances. Moreover, the total antioxidant capacity, 6-sulfatoxymelatonin and urinary cortisol levels, and other biological parameters improve after the ingestion of melatonin. Recent investigations have proposed a pathophysiological relationship between mitochondrial dysfunction, oxidative stress, and FMS by looking at certain proteins involved in mitochondrial homeostasis according to the etiopathogenesis of this syndrome. These improvements exert positive effects on the quality of life of FMS patients, suggesting that the use of melatonin as a coadjuvant may be a successful strategy for the management of this syndrome.
Sliding-Mode Control for Stabilizing High-Order Stochastic Systems: Application to One-Degree-of-Freedom Aerial Device

This paper is concerned with the problem of designing a control strategy to guarantee stability in probability for high-order stochastic systems. The control hinges on the sliding-mode scheme. We first prove that the control design can stabilize a fast terminal sliding-mode function. We further show that the stable sliding mode is able to assure the stability in probability for the high-order stochastic system. The resulting system may account nonvanishing diffusion terms, which is regarded as a novelty. The derived control strategy has implications for applications—experiments are carried out to control the pitch angle of a one-degree-of-freedom aerial device. The corresponding experimental results demonstrate the benefits and effectiveness of our approach.
Unsteady boundary layer flow past a vertical plate in the presence of transverse magnetic field and heat source embedded in a porous medium

An investigation into the unsteady boundary layer flow past a vertical plate in the presence of transverse magnetic field and heat source embedded in a porous medium has been studied . The governing differential equation was transformed using suitable dimensionless parameters. The dimensionless equations were solved employing the Laplace transform techniques and results illustrated graphically for the velocity, temperature and concentration profiles as well as the Skin friction, Sherwood number and Nusselt number. The study concluded that all the controlling parameters had effects on the flow and can be used to control the flow kinematics.
Inertial Sensor Technologies—Their Role in Equine Gait Analysis, a Review

Objective gait analysis provides valuable information about the locomotion characteristics of sound and lame horses. Due to their high accuracy and sensitivity, inertial measurement units (IMUs) have gained popularity over objective measurement techniques such as force plates and optical motion capture (OMC) systems. IMUs are wearable sensors that measure acceleration forces and angular velocities, providing the possibility of a non-invasive and continuous monitoring of horse gait during walk, trot, or canter during field conditions. The present narrative review aimed to describe the inertial sensor technologies and summarize their role in equine gait analysis. The literature was searched using general terms related to inertial sensors and their applicability, gait analysis methods, and lameness evaluation. The efficacy and performance of IMU-based methods for the assessment of normal gait, detection of lameness, analysis of horse–rider interaction, as well as the influence of sedative drugs, are discussed and compared with force plate and OMC techniques. The collected evidence indicated that IMU-based sensor systems can monitor and quantify horse locomotion with high accuracy and precision, having comparable or superior performance to objective measurement techniques. IMUs are reliable tools for the evaluation of horse–rider interactions. The observed efficacy and performance of IMU systems in equine gait analysis warrant further research in this population, with special focus on the potential implementation of novel techniques described and validated in humans.
$p$-adic Distance, Finite Precision and Emergent Superdeterminism: A Number-Theoretic Consistent-Histories Approach to Local Quantum Realism

Although the notion of superdeterminism can, in principle, account for the violation of the Bell inequalities, this potential explanation has been roundly rejected by the quantum foundations community. The arguments for rejection, one of the most substantive coming from Bell himself, are critically reviewed. In particular, analysis of Bell's argument reveals an implicit unwarranted assumption: that the Euclidean metric is the appropriate yardstick for measuring distances in state space. Bell's argument is largely negated if this yardstick is instead based on the alternative $p$-adic metric. Such a metric, common in number theory, arises naturally when describing chaotic systems which evolve precisely on self-similar invariant sets in their state space. A locally-causal realistic model of quantum entanglement is developed, based on the premise that the laws of physics ultimately derive from an invariant-set geometry in the state space of a deterministic quasi-cyclic mono-universe. Based on this, the notion of a complex Hilbert vector is reinterpreted in terms of an uncertain selection from a finite sample space of states, leading to a novel form of `consistent histories' based on number-theoretic properties of the transcendental cosine function. This leads to novel realistic interpretations of position/momentum non-commutativity, EPR, the Bell Theorem and the Tsirelson bound. In this inherently holistic theory - neither conspiratorial, retrocausal, fine tuned nor nonlocal - superdeterminism is not invoked by fiat but is emergent from these `consistent histories' number-theoretic constraints. Invariant set theory provides new perspectives on many of the contemporary problems at the interface of quantum and gravitational physics, and, if correct, may signal the end of particle physics beyond the Standard Model.
Climatology and Interannual Variability of Winter North Pacific Storm Track in CMIP5 Models

We examine the capability of thirteen Coupled Model Intercomparison Project (CMIP) phase 5 (CMIP5) models in simulating climatology and interannual variability of Winter North Pacific Storm Track (WNPST). It is found that nearly half of the selected models can reproduce the spatial pattern of WNPST climatology. However, the strength and spatial variation of WNPST climatology are weak in most of the models. Most differences among the models are in the northeast of the simulated multi-model ensemble (MME) climatology, while it is more consistent in the south. The MME can reflect not only the center position, but also the strength and spatial distribution of interannual variation of the WNPST amplitude. Except for CNRM-CM5, the interannual standard deviations of simulated WNPST strength and spatial variation in all other models are weak. ACCESS1-3 and CanESM2 have a better capability in simulating the spatial modes of WNPST, while the simulated second and third modes in some models are in opposite order with those in NCEP (National Centers for Environmental Prediction) reanalysis. Only five models and MME can capture “midwinter suppression” feature in their simulations. Compared with NCEP reanalysis, the winter longitude index is larger and latitude index is smaller in most of the models, indicating the simulated storm track is further east and south. CNRM-CM5, MME and CMCC-CM could be used to evaluate interannual variation of strength index, longitude index and latitude index respectively. Nevertheless, only INM-CM4 and CNRM-CM5 can simulate southward drift of WNPST.
Positive or Negative Reviews? Consumers' Selective Exposure in Seeking and Evaluating Online Reviews

How and why positive and negative reviews influence product sales differently has critical implications for both research and businesses. Although earlier online word-of-mouth research empirically documented that negative reviews influence product sales to a greater extent than positive reviews (i.e., a negativity bias), later research has revealed that positive reviews are generally more helpful (i.e., a positivity bias). We propose that an answer to this conundrum may be that negative reviews get more exposure than positive reviews. As consumers are often overwhelmed by the massive number of online reviews, they need to be selective when searching for reviews. This research investigates consumers’ preference for positive vs. negative reviews during both the information-seeking and information-evaluation stages of their decision-making process. Drawing on the motivated reasoning literature, we propose that consumers exhibit a negativity bias when they search for reviews to read but manifest a confirmation bias when they evaluate the helpfulness of reviews. We conducted three experiments and found consistent support for these hypotheses. Our findings expand the current understanding of consumers’ processing of online reviews to the information-seeking stage, reveal differential biases at different stages, demonstrate a possible explanation for the negativity bias in product sales, and provide important practical implications.
Genome-Wide SNP and Indel Discovery in Abaca (Musa textilis Née) and among Other Musa spp. for Abaca Genetic Resources Management

Abaca (Musa textilis Née) is an economically important fiber crop in the Philippines. Its economic potential, however, is hampered by biotic and abiotic stresses, which are exacerbated by insufficient genomic resources for varietal identification vital for crop improvement. To address these gaps, this study aimed to discover genome-wide polymorphisms among abaca cultivars and other Musa species and analyze their potential as genetic marker resources. This was achieved through whole-genome Illumina resequencing of abaca cultivars and variant calling using BCFtools, followed by genetic diversity and phylogenetic analyses. A total of 20,590,381 high-quality single-nucleotide polymorphisms (SNP) and DNA insertions/deletions (InDels) were mined across 16 abaca cultivars. Filtering based on linkage disequilibrium (LD) yielded 130,768 SNPs and 13,620 InDels, accounting for 0.396 ± 0.106 and 0.431 ± 0.111 of gene diversity across these cultivars. LD-pruned polymorphisms across abaca, M. troglodytarum, M. acuminata and M. balbisiana enabled genetic differentiation within abaca and across the four Musa spp. Phylogenetic analysis revealed the registered varieties Abuab and Inosa to accumulate a significant number of mutations, eliciting further studies linking mutations to their advantageous phenotypes. Overall, this study pioneered in producing marker resources in abaca based on genome-wide polymorphisms vital for varietal authentication and comparative genotyping with the more studied Musa spp.
High-resolution Spectroscopic Abundances of Red Giant Branch Stars in NGC 6584 and NGC 7099

We obtain high-resolution spectra of red giant branch stars in NGC 6584 and NGC 7099 to perform a detailed abundance analysis. We confirm cluster membership for these stars based on consistent radial velocities measured in this study and small pixel offsets between the observations of Sarajedini et al. and Piotto et al. We find mean metallicities of [Fe/H] = −1.53 ± 0.08 dex and [Fe/H] = −2.29 ± 0.07 dex for NGC 6584 and NGC 7099, respectively. We also find these clusters to be enhanced in their [α/Fe] ratios, consistent with what is expected for metal-poor globular clusters. Additionally, we find evidence of a statistically significant Na–O anti-correlation in both clusters. Finally, with the use of HST photometry, we compare the location of the enhanced and pristine populations in chromosome maps of the clusters to confirm previous photometric evidence of multiple stellar populations. Although we cannot confirm the nature of the polluter stars responsible for the abundance differences, our results can be used to constrain pollution models.
Development and optimization of pharmacotherapy for chronic heart failure with regards to kidney functional state

the aim of the study was to estimate the effect of losartan on kidney function and renal blood flow in 78 patients with chronic heart failure (CHF) in the II–III functional class (FC). The treatment during 6 months with inclusion of lozartan resulted in improvement of the parameters of kidney functional state with reliable increase in GFR and improvement of parameters of the renal blood flow.
Evolutionary modifications of Astyanax larval prey capture (LPC) in a dark environment

Feeding strategies of an organism depend on the multimodal sensory processing that most efficiently integrates available visual, chemosensory, and/or mechanoreceptive cues as part of their environmental adaptation. The blind cavefish morph of Astyanax mexicanus has developed sensory-dependent behaviors to find food more efficiently than their eyed, surface-morph counterparts while in darkness. In the absence of light, adult cavefish have evolved enhanced behaviors, such as vibration attraction behavior (VAB), and changes in feeding angle. Here, we identified evolved differences in cavefish larval prey capture (LPC) behavior. In the dark, LPC is more efficient in cavefish than in surface fish. Furthermore, different cave populations express laterality in their LPC and strike towards prey preferentially located on their left or right sides. This suggests the occurrence, to some extent, of divergent LPC evolution among cave populations. While LPC can be triggered exclusively by a vibration stimulus in both surface and cavefish, we provide evidence that LPC is, at least partially, a multimodal sensory process different from adult VAB. We also found that a lack of food may exacerbate the laterality of LPC. Thus, we proposed a mathematical model for explaining laterality based on a balance between: (1) enlarged range of foraging field (behavioral or perceptive) due to asymmetry, (2) food abundance, and (3) disadvantages caused by laterality (unequal lateral hydrodynamic resistance when swimming, allocation of resources for the brain and receptors, and predator escape).
Environmental, social and governance scores in Europe: what drives financial performance for larger firms?

This paper aims to investigate the association between firms’ financial performance and their sustainability performance, as measured by Tobin's Q, with a focus on the individual ESG pillars. Our study analyzes constituents of the Stoxx Europe 600 index. We employ different econometric approaches and perform a comprehensive analysis of the post-2015 agreement concerning climate change. Results suggest a statistically positive relationship between firms’ ESG and financial performance, although of greater magnitude for the social component. Overall, our findings highlight the superior relevance of social performance in yielding shareholder value for the largest European firms.