Miracle-dz/UniFAR-FTUs huggingface dataset:
Prediction of Gastric Gastrointestinal Stromal Tumors before Operation: A Retrospective Analysis of Gastric Subepithelial Tumors

Gastrointestinal stromal tumors (GISTs), leiomyomas, and schwannomas are the most common gastric subepithelial tumors (GSETs) with similar endoscopic findings. Preoperative prediction of GSETs is difficult. This study analyzed and predicted GSET diagnosis through a retrospective review of 395 patients who underwent surgical resection of GISTs, leiomyomas, and schwannomas measuring 2–10 cm. GSETs were divided by size (group 2–5, >2 and ≤5 cm; group 5–10, >5 and ≤10 cm) for analysis. Demographics, clinical symptoms, and images were analyzed. A recursive partitioning analysis (RPA) was used to identify optimal classifications for specific GSET diagnoses. GIST patients were relatively older than other patients. Both groups had higher proportions of UGI bleeding, lower hemoglobin (Hb) levels, and a higher ratio of necrosis on their computed tomography (CT) scans. The RPA tree showed that (a) age ≤ 55, Hb ≥ 10.7, and CT necrosis; (b) age ≤ 55 and Hb < 10.7; (c) age >55 and Hb < 12.9; and (d) age >55 and CT hetero-/homogeneity can predict high GIST risk in group 2–5. Positive or negative CT necrosis, with age >55, can predict high GIST risk in group 5–10. GIST patients were older and presented with low Hb levels and tumor necrosis. In RPA, the accuracy reached 85% and 89% in groups 2–5 and 5–10, respectively.
KAJIAN KANDUNGAN BAHAN TAMBAHAN PANGAN BERBAHAYA 2018– 2019 SE-KOTA PEKALONGAN DAN IMPLEMENTASI PERDA KOTA PEKALONGAN NOMOR 07 TAHUN 2013

Supervision of food safety in Pekalongan City in 2010-2012 shows 6.27% of food contains hazardous food additives. Pekalongan City Government policies related to food safety are contained in Pekalongan City Regional Regulation Number 7 of 2013, but their implementation has not been studied. The research objective was to further identify types of food co ntaining dangerous hazardous food additives, to further identify the implementation of Pekalongan City Regulation No. 07 of 2013, and further identify the knowledge and attitudes of food producers in Pekalongan City. This research design is a combination of quantitative and qualitative studies. The results of the research further identified that the types of food that were most often found to contain hazardous food additives were dangerous for the types of preservatives (formalin and borax), namely meatball, indi and cilok types of food; yellow noodles; and terinasi (teri Medan); and otak-otak, while the dangerous hazardous food additives types of dye (Rhodamin B and Methanil Yellow) are Krupukuseg red colored; powdered seasoning; krupuk useg yellow colored; and pudding. Pekalongan City Regulation No.7 of 2013 concerning the Prohibition of the Use of Hazardous hazardous food additives, has been well implemented, but not optimal. Some of the knowledge and attitudes of producers in Pekalongan City already know about food safety. Keywords: Hazardous food additives, food safety, local regulations
Clostridial Diseases of Horses: A Review

The clostridial diseases of horses can be divided into three major groups: enteric/enterotoxic, histotoxic, and neurotoxic. The main enteric/enterotoxic diseases include those produced by Clostridium perfringens type C and Clostridioides difficile, both of which are characterized by enterocolitis. The main histotoxic diseases are gas gangrene, Tyzzer disease, and infectious necrotic hepatitis. Gas gangrene is produced by one or more of the following microorganisms: C. perfringens type A, Clostridium septicum, Paeniclostridium sordellii, and Clostridium novyi type A, and it is characterized by necrotizing cellulitis and/or myositis. Tyzzer disease is produced by Clostridium piliforme and is mainly characterized by multifocal necrotizing hepatitis. Infectious necrotic hepatitis is produced by Clostridium novyi type B and is characterized by focal necrotizing hepatitis. The main neurotoxic clostridial diseases are tetanus and botulism, which are produced by Clostridium tetani and Clostridium botulinum, respectively. Tetanus is characterized by spastic paralysis and botulism by flaccid paralysis. Neither disease present with specific gross or microscopic lesions. The pathogenesis of clostridial diseases involves the production of toxins. Confirming a diagnosis of some of the clostridial diseases of horses is sometimes difficult, mainly because some agents can be present in tissues of normal animals. This paper reviews the main clostridial diseases of horses.
Vertical Shears of Horizontal Winds in the Lower Thermosphere Observed by ICON

Vertical shears of horizontal winds play an important role in the dynamics of the upper atmosphere. Prior observations have indicated that these shears predominantly occur in the lower thermosphere. MIGHTI observations from the Ionospheric Connection Explorer indicate that strong wind shears are a common feature of the lower thermosphere between 100–130 km, varying greatly between orbits. This work focuses on these strong shears, and examines their occurrences, horizontal scales and underlying organization. The wind shears can persist for 1000s km horizontally. Over a large data set, no preferred direction for the strong wind shears is found. The shears that persist for a short horizontal extent are slightly larger in amplitude and more numerous than those that persist across large horizontal scales. The altitude at which the strongest shears occur, regardless of the horizontal extent, show a downward progression with local time, following the climatological winds and upward propagating tides.
Effects of Pain Neuroscience Education Combined with Lumbar Stabilization Exercise on Strength and Pain in Patients with Chronic Low Back Pain: Randomized Controlled Trial

Chronic low back pain that lasts more than 12 weeks causes mental and physical distress. This study investigated the effects of pain neuroscience education combined with lumbar stabilization exercises on strength, pain, flexibility, and activity disorder index in female patients with chronic low back pain. Thirty-five female patients with chronic low back pain were randomly divided into two groups: the pain neuroscience education (PNE) combined with lumbar stabilization exercises (LSEs) group (n = 18, experimental group) and the lumbar stabilization exercises alone group (n = 17, control group). The experimental group underwent PNE combined with LSEs for 30 min per session, twice per week for 8 weeks, and the control group underwent LSEs only. The primary outcomes were strength (sit-up and back-up movements), Numerical Pain Rating Scale (NPRS), Korean Pain Catastrophizing Scale (K-PCS), and Tampa Scale of Kinesio-phobia-11 (TSK-11) for pain. The secondary outcomes were modified–modified Schober’s test (MMST) and finger to floor test (FFT) for flexibility and activity disorder (Roland–Morris Disability Questionnaire index). A significant difference was observed in the primary outcomes after intervention in the abdominal muscle strength (group difference, mean, −7.50; 95% CI, −9.111 to –5.889, F = 9.598; ANCOVA p = 0.005), the back muscle strength (group difference, mean, −9.722; 95% CI, −10.877 to –8.568, F = 7.102; ANCOVA p = 0.014), the NPRS (group difference, mean, 1.89; 95% CI,1.65 to 2.12, F = 24.286; ANCOVA p < 0.001), K-PCS (group difference, mean, 7.89; 95% CI, 7.02 to 8.76, F = 11.558; ANCOVA p = 0.003), and TSK-11 (group difference, mean, 16.79; 95% CI, 13.99 to 19.59, F = 13.179; ANCOVA p = 0.014) for pain. In the secondary outcomes, there was a significant difference in the FFT (group difference, mean, −0.66; 95%CI, −0.99 to −0.33, F = 4.327; ANCOVA p = 0.049), whereas the difference in flexibility (MMST) and activity disorder index of the secondary outcomes did not reach significance. Therefore, this study confirmed that PNE combined with LSEs is an effective intervention compared to LSE alone in improving muscle strength and pain in female patients with chronic low back pain.
MEG3 LncRNA from Exosomes Released from Cancer-Associated Fibroblasts Enhances Cisplatin Chemoresistance in SCLC via a MiR-15a-5p/CCNE1 Axis

Purpose Long non-coding RNAs (lncRNAs) may act as oncogenes in small-cell lung cancer (SCLC). Exosomes containing lncRNAs released from cancer-associated fibroblasts (CAF) accelerate tumorigenesis and confer chemoresistance. This study aimed to explore the action mechanism of the CAF-derived lncRNA maternally expressed gene 3 (MEG3) on cisplatin (DDP) chemoresistance and cell processes in SCLC. Materials and Methods Quantitative real-time PCR was conducted to determine the expression levels of MEG3, miR-15a-5p, and CCNE1. Cell viability and metastasis were measured by 3-(4, 5-dimethyl-2-thiazolyl)-2, 5-diphenyl-2-h-tetrazolium bromide and invasion assays, respectively. A xenograft tumor model was developed to confirm the effect of MEG3 overexpression on SCLC progression in vivo. Relationships between miR-15a-5p and MEG3/CCNE1 were predicted using StarBase software and validated by dual luciferase reporter assay. Western blotting was used to determine protein levels. A co-culture model was established to explore the effects of exosomes on MEG3 expression in SCLC cell lines. Results MEG3 was overexpressed in SCLC tissues and cells. MEG3 silencing significantly repressed cell viability and metastasis in SCLC. High expression of MEG3 was observed in CAF-derived conditioned medium (CM) and exosomes, and promoted chemoresistance and cancer progression. Additionally, MEG3 was found to serve as a sponge of miR-15a-5p to mediate CCNE1 expression. Overexpression of miR-15a-5p and knockout of CCNE1 reversed the effects of MEG3 overexpression on cell viability and metastasis. Conclusion MEG3 lncRNA released from CAF-derived exosomes promotes DDP chemoresistance via regulation of a miR-15a-5p/CCNE1 axis. These findings may provide insight into SCLC therapy.
Sexual Satisfaction in Portuguese Women: Differences Between Women With Clinical, Self-Perceived and Absence of Sexual Difficulties

Abstract Objectives Female sexual functioning and satisfaction are affected by the presence of sexual difficulties. The current study examines differences in sexual satisfaction according to three groups of women: (i) clinical sexual difficulties assessed by the Female Sexual Functioning Index (FSFI) cutoff; (ii) self-perceived sexual difficulties at a non-clinical level; and (iii) sexually healthy. Methods A convenience sample of 329 Portuguese women, with a mean age of 28.69 (SD = 8.78), answered a specific question on the presence of self-perceived sexual difficulties, the Sexual Satisfaction Scale for Women and the FSFI. From the 329 women, 56 were assigned to the group with clinical sexual difficulties, 60 were assigned to the group with self-perceived sexual difficulties at non-clinical level, and 213 constituted the sexually healthy group. Results Sexually healthy women were more sexually satisfied compared with women who self-perceived sexual difficulties and women who had clinical sexual difficulties according to the FSFI. In addition, women who self-perceived sexual difficulties were also more sexually satisfied compared to women with clinical sexual difficulties according to the FSFI. Conclusions Women's sexual satisfaction was negatively affected by sexual difficulties assessed by the FSFI cutoff. Although with less impact, self-perceived sexual difficulties also negatively affect women's sexual satisfaction.
The intersection of damage evaluation of fiber-reinforced composite materials with machine learning: A review

Machine learning (ML) has emerged as a useful predictive tool based on mathematical and statistical relationships for various engineering problems. The pairing of structural health monitoring (SHM) and nondestructive evaluation (NDE) methods with ML algorithms has yielded beneficial results in addressing the damage state of a material or system. Damage state descriptions addressed with ML include detecting a damage mechanism, locating a mechanism, identifying the type of mechanism, assessing the extent of the damage mechanism, and estimating the useful remaining life of a material or system. Damage evaluation research of composite materials has progressed with the increased usage of composite structural elements in the aerospace industry. NDE methods are a viable candidate for pairing with ML algorithms to improve damage state monitoring of composite materials due to the complexity associated with the structure of composites. Fiber-reinforced polymers (FRP), for example, contain at least two constituent materials a fiber and matrix material whose mechanical behavior and interactions contribute to the performance of an FRP. Unlike conventional composite analytical models that require explicit information about the constituents and microstructure of a laminate, an ML algorithm can construct damage evaluation predictions when employing exclusively past operational performance or data from an SHM or NDE method. A researcher determines the type of data selected when applying an ML model for trend analysis, anomaly detection, or prediction making. However, no one specific input feature is required for utilizing an ML model, and examples of possible data features include material properties, physical dimensions, and collected evaluation data. In the present review, applications of ML combined with the damage state evaluation of composite materials, particularly examining FRPs, are discussed to demonstrate the predictive capabilities of ML and its viability for future applications, especially in industrial environments, to minimize costs and improve damage detection rates.
An associated result of the Van Aubel configuration and its generalization

This note presents some novel generalizations to similar quadrilaterals, similar parallelograms, and similar triangles of a result associated with Van Aubel’s theorem about squares constructed on the sides of a quadrilateral. These results provide problem posing opportunities for interesting, challenging explorations for talented students using dynamic geometry at high school or for university students.
Application of effective wavelengths for variety identification of instant milk teas

Based on least squares-support vector machine (LS-SVM),the effective wavelength (EW) in visible/near infrared (Vis/NIR) region was proposed as a new approach for the variety discrimination of instant milk teas. This method uses 225 milk tea samples for the calibration set,while 75 samples for the validation set. After partial least squares (PLS) analysis,the EWs were selected according to the X-loading weights and regression coefficients,and an EW-LS-SVM model was developed for the variety discrimination. The PC-LS-SVM model using principal components (PCs) and the WT-LS-SVM model using wavelet transform (WT) were built for comparison. The recognition ratios of calibrations using EW,PC and WT were all 100%,for the calibration set,while 98.7%,98.7% and 100% for the validation set,respectively. An excellent recognition ratio was achieved by these three models. It is feasible to use effective wavelengths in Vis/NIR region for the variety discrimination of instant milk teas and the EW-LS-SVM model can achieve a satisfying recognition ratio.
Using groundwater in the hyper-arid Atacama Desert to discover buried hydrothermal mineral deposits

ABSTRACT Epithermal deposits occur in many metallogenic belts globally and are economically important sources of precious and base metals. However, post-mineral cover (both transported and younger deposits) also occurs in many prospective districts and hinders exploration efforts. Hydrogeochemistry is a potentially useful exploration tool in these environments, with water–rock interaction shown from other studies to produce large hydrogeochemical footprints. Groundwaters from in and around the Vaquillas (Au-Ag) epithermal deposit in the pre-cordillera of northern Chile are typically Ca-SO4 2- type with meteoric upflow groundwaters interacting with the ore body and producing a significant downflow (down hydraulic head) mobility (up to 3 km) of (oxy)anions of arsenic and molybdenum, which contrasts with proximal trace cation anomalies. Multiple sulphur endmembers contribute to the dissolved sulphate concentrations, including evaporites, primary hypogene sulphide minerals, and a single δ34S(SO4) value of 30.1 ‰ which is potentially associated with disproportionated sulphur in sulphate. This study reports anomalism from one of the most dilute endmember groundwater compositions from Chile reported to date. The sub-alkaline and weakly oxygenated groundwaters are common in many aquifers globally, making the results applicable to many other metallogenic belts. It is also the first hydrogeochemical case study of an intermediate-sulfidation epithermal deposit. Despite the highly dilute groundwaters recharging aquifers at Vaquillas, we conclude hydrogeochemistry to be a highly effective exploration tool for epithermal and porphyry deposits in areas of significant post-mineral cover.
Diversity and Abundance of Ant (Formicidae) Functional Groups in Range of Land Use Systems in Jambi, Sumatra

Kerusakan hutan tropika basah dapat menimbulkan dampak lingkungan berupa penurunan keanekaragaman hayati dan terganggunya fungsi serta stabilitas ekosistem. Tujuan dari penelitian ini adalah untuk mendapatkan bukti apakah perubahan hutan tropika basah menjadi bentuk penggunaan lahan lain berakibat pada penurunan keragaman dan kelimpahan semut, dan untuk menunjukkan apakah semut dapat dijadikan sebagai bio-indikator perubahan sistem penggunaan lahan (SPL). Penelitian ini dilakukan di Jambi Sumatra pada akhir musim penghujan (Mei−Juni) 2004 pada berbagai taraf intensifikasi SPL. Inventarisasi dan koleksi semut dilakukan dengan menggunakan metode “Winkler” pada enam SPL, yaitu: hutan primer, hutan sekunder, perkebunan karet, perkebunan kelapa sawit, ladang ketela pohon, dan padang alang-alang. Hasil penelitian menunjukkan bahwa ditemukan 50 genus semut pada 6 SPL tersebut. SPL tidak berpengaruh secara nyata terhadap keragaman dan kelimpahan seluruh semut tetapi berpengaruh secara nyata terhadap kelompok semut pesaba dan semut predator. Keragaman jenis dan kelimpahan yang tinggi dari semut predator ditemukan pada SPL hutan primer dan hutan sekunder. Keragaman jenis dan kelimpahan menjadi rendah apabila SPL hutan diubah menjadi SPL ladang ketela pohon. Kelimpahan semut pesaba tertinggi diketemukan pada SPL perkebunan kelapa sawit. Data yang diperoleh menunjukkan bahwa semut dapat digunakan sebagai bio-indikator dalam perubahan SPL di kawasan Jambi, Sumatra.
Personalized Nutrition in Patients with Type 2 Diabetes and Chronic Kidney Disease: The Two-Edged Sword of Dietary Protein Intake

In type 2 diabetes (T2D), there is a general and strong focus on carbohydrate restriction. However, this may have unwarranted consequences for those with concomitant chronic kidney disease (CKD) since decreasing intake of carbohydrates implies a higher proportion of dietary protein, which is of critical debate in patients with CKD due to its ambiguous implications in maintaining either kidney function or nutritional status. We evaluated adherence to the protein recommendations, taking into account the nutritional status of patients with T2D with or without CKD. Patients were divided in three groups according to their estimated Glomerular Filtration Rate (eGFR): mild to no CKD (eGFR > 60 mL/min/1.73 m2), moderate CKD (eGFR 30–60 mL/min/1.73 m2), or advanced CKD (eGFR < 30 mL/min/1.73 m2). Regarding adherence to the protein recommendations, 17% of the patients without advanced CKD consumed < 0.8 g/kg/day, 29% of the patients with moderate CKD consumed > 1.3 g/kg/day, and 60% of the patients with advanced CKD consumed > 1.0 g/kg/day. In addition, patients with moderate- or advanced CKD tend to have a lower muscle mass, normalized by height, compared to patients with mild to no CKD (p < 0.001), while body mass index was not significantly different between patients with or without CKD (p = 0.44). We found that although dietary protein restriction has not been indicated in either of the CKD stages, approximately 10% had a dietary protein intake < 0.8 g/kg/day, with accompanying risks of malnourishment and sarcopenia. Our main advice is to maintain a dietary protein intake of at least 0.8 g/kg/day in order to prevent patients from becoming malnourished and sarcopenic.
Two-year outcomes of UK patients newly diagnosed with atrial fibrillation: findings from the prospective observational cohort study GARFIELD-AF

Background The outcomes of patients newly diagnosed with atrial fibrillation (AF) following the introduction of direct-acting oral anticoagulants are not well known. Aim To determine the 2-year outcomes of patients newly diagnosed with AF, and the effectiveness of oral anticoagulants in everyday practice. Design and setting This was a prospective observational cohort study in UK primary care. Method In total, 3574 patients aged ≥18 years with a new AF diagnosis were enrolled. A propensity score was applied using an overlap weighting scheme to obtain unbiased estimates of the treatment effect of anticoagulation versus no anticoagulation on the occurrence of death, non-haemorrhagic stroke/systemic embolism, and major bleeding within 2 years of diagnosis. Results Overall, 65.8% received anticoagulant therapy, 20.8% received an antiplatelet only, and 13.4% received neither. During the study period, the overall incidence rates of all-cause mortality, non-haemorrhagic stroke/systemic embolism, and major bleeding were 4.15 (95% confidence interval [CI] = 3.69 to 4.65), 1.45 (95% CI = 1.19 to 1.77), and 1.21 (95% CI = 0.97 to 1.50) per 100 person–years, respectively. Anticoagulation treatment compared with no anticoagulation treatment was associated with significantly lower all-cause mortality adjusted hazard ratio (aHR) 0.70 (95% CI = 0.53 to 0.93), significantly lower risk of non-haemorrhagic stroke/systemic embolism (aHR 0.39, 95% CI = 0.24 to 0.62), and a non-significant higher risk of major bleeding (aHR 1.31, 95% CI = 0.77 to 2.24). Conclusion The data support a benefit of anticoagulation in reducing stroke and death, without an increased risk of a major bleed in patients with new-onset AF. Anticoagulation treatment in patients at high risk of stroke who are not receiving anticoagulation may further improve outcomes.