Miracle-dz/UniFAR-FTUs huggingface dataset:
Predicting and influencing PrEP use: the role of motivational and attitudinal factors

ABSTRACT This study examined PrEP attitude and HIV risk factors associated with PrEP motivation and evaluated the efficacy of a mock public health video that addresses both motivational and stigma issues for improving PrEP uptake over a standard educational video. Gay, bisexual, and other men who have sex with men (GBMSM; N = 604) were enrolled. One-way between subject analysis of variance (ANOVA) and post-hoc comparisons revealed that GBMSM in later stages of change had significantly higher endorsement of positive PrEP attitudes, PrEP stigma, objective and perceived HIV risk, HIV worry, and valued health benefits of PrEP more. Stepwise multiple regression revealed five significant predictors of PrEP motivation: HIV worry, objective HIV risk, anticipated PrEP stigma, positive PrEP attitudes, and perceived social consequences of PrEP use. Video conditions did not differ in their impact on PrEP attitudes or motivation; however, regardless of video condition, participants experienced a pre- to post-video increase in positive PrEP attitudes and motivation. Findings suggest HIV worry, objective HIV risk, positive PrEP attitudes, and perceived PrEP health benefits are important factors to optimize PrEP motivation, which can inform secondary prevention efforts. Further study is needed on promotional PrEP campaigns that disconfirm stigmatizing PrEP misconceptions.
Incretin and Pancreatic β-Cell Function in Patients with Type 2 Diabetes

To maintain normal glucose homeostasis after a meal, it is essential to secrete an adequate amount of insulin from pancreatic β-cells. However, if pancreatic β-cells solely depended on the blood glucose level for insulin secretion, a surge in blood glucose levels would be inevitable after the ingestion of a large amount of carbohydrates. To avoid a deluge of glucose in the bloodstream after a large carbohydrate- rich meal, enteroendocrine cells detect the amount of nutrient absorption from the gut lumen and secrete incretin hormones at scale. Since insulin secretion in response to incretin hormones occurs only in a hyperglycemic milieu, pancreatic β-cells can secrete a “Goldilocks” amount of insulin (i.e., not too much and not too little) to keep the blood glucose level in the normal range. In this regard, pancreatic β-cell sensitivity to glucose and incretin hormones is crucial for maintaining normal glucose homeostasis. In this Namgok lecture 2022, we review the effects of current anti-diabetic medications on pancreatic β-cell sensitivity to glucose and incretin hormones.
Observation of Moisture Tendencies Related to Shallow Convection

AbstractTropospheric moisture is a key factor controlling the global climate and its variability. For instance, moistening of the lower troposphere is necessary to trigger the convective phase of a Madden–Julian oscillation (MJO). However, the relative importance of the processes controlling this moistening has yet to be quantified. Among these processes, the importance of the moistening by shallow convection is still debated. The authors use high-frequency observations of humidity and convection from the Research Vessel (R/V) Mirai that was located in the Indian Ocean ITCZ during the Cooperative Indian Ocean Experiment on Intraseasonal Variability/Dynamics of the MJO (CINDY/DYNAMO) campaign. This study is an initial attempt to directly link shallow convection to moisture variations within the lowest 4 km of the atmosphere from the convective scale to the mesoscale. Within a few tens of minutes and near shallow convection occurrences, moisture anomalies of 0.25–0.5 g kg−1 that correspond to tendencies on .
Antimicrobial resistance in sexually transmitted Shigella in men who have sex with men: A systematic review

Background Outbreaks of sexually transmitted Shigella flexneri and Shigella sonnei in men who have sex with men (MSM) are a major public health issue. While most cases can be managed conservatively, a minority require antimicrobial treatment. Recent reports have highlighted increasing antimicrobial resistant (AMR) strains of Shigella spp. in men who have sex with men. We aimed to systematically review antimicrobial resistance (and decreased antimicrobial sensitivity) in sexually transmitted shigella in men who have sex with men, focussing on macrolides, quinolones, and third generation cephalosporins. Methods We systematically searched 4 bibliographical databases (EMBASE, medline, EMCARE and CINAHL) from January 2011 to November 2021. We used a 2-stage process to assess eligibility: the primary author conducted an initial screen and then 3 authors conducted independent full-text reviews to determine the final eligible manuscripts. We only included manuscripts in English which included men who have sex with men with sexually transmitted shigella where data on antimicrobial resistance was available. Results Thirty-nine manuscripts met the inclusion criteria. A majority of the manuscripts (N = 34) described reduced susceptibility or antimicrobial resistant to macrolides, quinolones and third generation cephalosporins in circulating strains of shigella within sexual networks of men who have sex with men. Extensively drug resistant outbreaks of shigella in men who have sex with men have been reported containing genetic markers of ceftriaxone resistance (e.g. BlaCTX-M27) where isolates also contained markers of reduced susceptibility, and antimicrobial resistant to macrolides and quinolones. Conclusion There is little role for macrolides, quinolones or third generation cephalosporins in the management of sexually transmitted shigella in men who have sex with men. More research is needed to develop novel strategies for shigella control in men who have sex with men, as antimicrobial options are diminishing.
Future Directions in Youth and Family Treatment Engagement: Finishing the Bridge Between Science and Service

ABSTRACT The field has spent more than 50 years investing in the quality of youth mental healthcare, with intervention science yielding roughly 1,300 efficacious treatments. In the latter half of this period, concurrent efforts in implementation science have developed effective methods for supporting front-line service organizations and therapists to begin to bridge the science to service gap. However, many youths and families still do not benefit fully from these strategic investments due to low treatment engagement: nearly half of youths in need of services pursue them, and among those who do, roughly another half terminate prematurely. The negative impact of low engagement is substantial, and is disproportionally and inequitably so for many. We contend that to build a robust and “finished” bridge connecting science and service, the field must go beyond its two historical foci of designing interventions and preparing therapists to deliver them, to include an intentional focus on the youths and families who participate in these interventions and who work with those therapists. In this paper, we highlight the significance of treatment engagement in youth mental healthcare and discuss the current state of the literature related to four priorities: conceptualization, theory, measurement, and interventions. Next, we offer an example from our own program of research as one illustration for advancing these priorities. Finally, we propose recommendations to act on these priorities.
How knowledge time influenced anxiety, depression, stress and quality of life levels in patients suffering from Crohn disease: a cross-sectional multicenter study

Background and aim of the work. The diagnosis of Crohn Disease (CD) represents a turning point in the life of patients, which inevitably marks them. The present study represents a direct “feed-back” from patients suffering from Crohn disease, in order to reveal how the diagnosis of CD changed lifestyles and psychological conditions in their patients. Specifically, how patients change their smoking habits, their alcohol and drug assumptions and their eating habits, particularly in high sugar and fats intakes. Additionally, by considering years of knowledge of the CD, if the time can influence psychological conditions of these patients, like: anxiety, depression and stress conditions, too. Methods. An observational, cross sectional, online, snowball sampling study was conducted through participants suffered from CD and belonged to social networks and Facebook groups. For each participant, sampling characteristics, a series of lifestyle habits Before to After the diagnosis of CD and anxiety, depression, and stress conditions were investigated. Results. A total of 785 participants agreed to participate. As Participants underwent significant challenges in their lifestyles after the CD diagnosis (p<0.001), specifically their reduced their smoking habits, alcohol and drugs intakes and also their diets both in high sugar and fatty compositions. Anxiety and stress levels were not statistical different among participants according to years of the knowledge of their CDs. Meanwhile, as regards depression condition, significantly higher levels were recorded among participants who knew their CD until 5 and 25 years, respectively (p=0.031). Conclusions. From the study emerges several aspects of quality of life compromised, a fact supported by the analysis of psychophysical sequelae, which allowed to lay the groundwork for further studies, studying the comorbidity of this disease with other factors. Future randomized controlled trials should deepen the correlation between eating disorders and CD, a link little explored in the literature. (www.actabiomedica.it)
Multi‐color photometric measurements of ionization and energies in sprites

Recent time‐resolved multi‐color photometric data obtained on one class of lightning‐related transient upper‐atmospheric electromagnetic events called sprites have confirmed an impulsive ionization emission during the sprite initiation. Data have also been obtained on some sprites which do not exhibit observable tendrils and which exhibit ionization emission that, if present, is below our detection limit. This suggests that some sprite events exhibit strong ionization while others do not. These results indicate that conditions causing sprite optical emissions are highly variable.
Headache comorbidity in refugees and migrants with post-traumatic stress disorder

Background Headache is often comorbid with post-traumatic stress disorder yet overlooked in health assessments of refugees. Objectives To describe prevalence of severe headache among refugees with post-traumatic stress disorder and compare severity of post-traumatic stress disorder symptoms and treatment outcomes among those with and without severe headache. Methods This follow-up study used data from the Danish Database on Refugees with Trauma. Participants were recruited from 2009 to 2015 at a specialized psychiatric clinic. Prevalence of severe headache was computed by age, sex, and history of head injury or torture. Severe headache was defined as maximum headache scores on the Hopkins Symptom Checklist, Symptom Checklist-90 or the Visual Analogue Scale. Groups with and without severe headache were described according to validated questionnaires before and after 12–18 months of multidisciplinary treatment for post-traumatic stress disorder. Regression analyses were used to analyze associations between headache at start of treatment and symptom burden post-treatment, controlled for pre-treatment scores and possible confounders. Results Among 403 female and 489 male participants, nearly all (97.5%) complained of headaches. Severe headache prevalence was 31.4% to 50.0% (depending on which questionnaire was used) and was significantly more common among females and those aged 30–49 years. There was no clear relationship between headache and head injury or torture. Participants with severe headache had heavier symptom burdens compared to those without severe headache. Post-treatment, headache prevalence by age and sex did not change significantly. Those without severe headache showed a tendency toward improvement in outcome measures; this was not seen among those with severe headache. Pre-treatment headache scores were correlated with all outcome measures. Regression analyses controlled for pre-treatment scores of the outcome variables showed associations between pre-treatment headache scores (Hopkins Symptom Checklist or Symptom Checklist-90) and post-treatment scores for intrusion, numbing, hyperarousal, anxiety, disability, and quality of life (all p < 0.02). Conclusion Headache is a prevalent comorbid condition among refugees with post-traumatic stress disorder. Measures of pre-treatment headache severity appear to predict post-traumatic stress disorder treatment outcomes. Severe headache adversely affects post-traumatic stress disorder prognosis. Assessment and treatment options should be studied further.
Anti-tumour and radiosensitising effects of PARP inhibitor on cervical cancer xenografts

Abstract This study evaluated the radiosensitising effect of niraparib; a poly(adenosine diphosphate-ribose) polymerase (PARP) inhibitor on HeLa cervical cancer cells in nude mice and explored its possible mechanism. Twenty-four 3–5-week-old female BALB/c nude mice, inoculated with HeLa cells into the right hind leg, were randomly assigned into eight groups with three mice per group and treated. The tumour volume was significantly reduced under niraparib + radiotherapy combination as compared to monotherapy and untreated mice. The tumour growth was significantly delayed by 23.33–39 days when treated with combination therapy (p<.05). Further, univariate analysis revealed prolonged time for tumour growth when radiotherapy was followed by niraparib (I.G.) rather than niraparib (I.P.) (p=.003). Combination therapy reduced levels of PARP-1 precursor, PARP-1 splicer, PAR and RAD51 protein with high expression of γ-H2AX/CC3 and low expression of Ki-67. Niraparib in combination with radiotherapy can enhance the formation of DNA double strand breaks in HeLa cells and up regulate the expression of γ-H2AX/CC3. IMPACT STATEMENT What is already known on this subject? Asia has the highest incidence of cervical cancer (58.2%). Poly(adenosine diphosphate-ribose) polymerases (PARPs) are family of enzymes involved in single-strand break (SSB) and double-strand break (DSB) repair pathways. Niraparib is an effective inhibitor of both PARP-1 and PARP-2 and has the ability to cross the blood–brain barrier. What the results of this study add? Our study demonstrated that the combination of niraparib and radiotherapy can significantly enhance the cytotoxicity induced by radiotherapy. The inhibition effect of radiotherapy combined with niraparib on the tumour growth of mice was prominent, thereby establishing the radio-sensitisation activity of niraparib. What are the implications of these findings for clinical practice and/or further research? Niraparib can improve the cytotoxic effect of radiotherapy by increasing the formation of DSBs and up regulating the expression of apoptotic protein in HeLa cells.
“If People Were Told About the Cancer, They’d Want to Get Vaccinated”: Knowledge, Attitudes, and Beliefs About HPV Vaccination Among Mid-Adult Men

In 2018, nine-valent human papillomavirus (HPV) vaccine eligibility expanded to include adults aged 27 to 45. This study aimed to identify knowledge, attitudes, and beliefs (KABs) about HPV and HPV vaccination among newly eligible mid-adult men, for whom uptake in adolescence and younger adulthood remains suboptimal. We conducted six virtual focus groups (N = 34 participants) with unvaccinated men aged 27 to 45 living in Southern California’s Inland Empire. Data were systematically analyzed to identify emergent themes using the rigorous and accelerated data reduction technique. The sample of men was diverse (79% Hispanic, non-Hispanic Black, Asian, or mixed race/ethnicity; 26% gay or bisexual) and captured participants from across the socioeconomic spectrum. Eighty-eight percent of participants had never received a provider recommendation to be vaccinated against HPV. Many had unanswered questions about HPV and HPV vaccination, could not recall any HPV-related cancers that affect men, and were unaware of their current eligibility for vaccination. Embarrassment and stigma surrounding vaccination against a sexually transmitted infection, concerns about vaccine side effects and safety, and preferences for preventing HPV via “safer sex” and monogamy were salient barriers to vaccination. Nevertheless, many men were eager to learn more about HPV vaccination and engage with health care providers around that topic. Interventions aimed at improving men’s knowledge, changing social norms, and supporting health providers to identify HPV vaccine-eligible patients may be especially fruitful for facilitating shared clinical decision-making between mid-adult men and their health care providers.
The Berry and Reinhardt Autoconversion Parameterization: A Digest

Abstract The simplified version of the Berry and Reinhardt parameterization used for initiating rain from cloud droplets is presented and is compared with 12 other versions of itself from the literature. Many of the versions that appear to be different from each other can be brought into agreement with the original parameterization by making the same assumptions: a mean diameter based upon mass or volume and distribution shape parameters chosen to give the same cloud mass relative variance as the original Berry and Reinhardt parameterization. However, there are differences in how authors have chosen to parameterize the cloud number concentration sink and rain number concentration source, and those choices, along with model limitations, have important impacts on rain development within the scheme. These differences among versions are shown to have important time-integrated feedbacks upon the developing initial rain distribution. Three of 12 implementations of the bulk scheme are shown to be able to reprodu.
Hospital Admissions for Personality Disorders Increased During the COVID-19 Pandemic

In Canada, the COVID-19 pandemic was associated with more negative self-perceived mental health in the general population, with a greater impact in younger age groups. A study of Ontarians aged 10+ found a decrease in emergency department visits and hospital admissions soon after the onset of the pandemic, followed by a subsequent return to prepandemic levels. In distinction, increased hospital admissions for eating disorders have been reported globally and in Canada. We sought to explore whether increased admissions occurred in diagnostic categories other than eating disorders by obtaining Alberta hospital discharge data for all hospital admissions having a most responsible diagnosis of a mental disorder. We focused on the 10–26 age range (the group in which the pandemic had its greatest impact and where anorexia nervosa (AN) typically has its onset and most severe manifestations) between 1 January 2018 and 31 December 2021. Counting back from the declaration of the global pandemic by the World Health Organization (11 March 2020) we estimated hospital admission rates in 3-month intervals prior to and after 11 March 2020, by dividing the number of hospital admissions within each 3-month interval by the mid-interval provincial population. Admission rates were then stratified by diagnostic group using both ICD-10 chapter categories and by specific diagnostic codes when sample size permitted. The rates were also stratified by age category (10–17 and 18–26) and by sex. We calculated 95% confidence intervals using Wilson’s method. We explored linear modelling approaches to describe temporal trends in the data. Models that regressed hospital admission rates by time had nonsignificant slopes, but plots of standardized residuals for these models consistently identified nonlinear patterns. Whereas some increases were observed, the most recent time intervals (10 June to 9 September 2021 and 10 September to 9 December 2021, corresponding to the 15– 21 months postpandemic onset) generally had admission rates resembling prepandemic rates. Due to the nonlinear patterns, a decision was made to describe the temporal patterns graphically rather than through linear modelling or an interrupted time series analysis. Distinctly increased rates were observed for 2 sets of conditions. First, for eating disorders an increase starting at about 6 months was followed by a gradual reduction in admission rates, trending back towards prepandemic levels. Confidence intervals (95%) for the 6to 9-month postpandemic interval were distinct from those of prepandemic levels indicating that the difference was unlikely to arise by chance, consistent with prior literature. Upon stratification, this increase was found to be exclusively due to AN (F50.0) and Atypical AN (F50.1), which is unsurprising since Bulimia Nervosa rarely leads to hospitalization. Stratification by age and sex was unsuccessful due to imprecision in the stratum-specific estimates.
Preclinical immunogenicity of an adenovirus-vectored vaccine for herpes zoster

ABSTRACT Herpes zoster (HZ) results from waning immunity following childhood infection with varicella zoster virus (VZV) but is preventable by vaccination with recombinant HZ vaccine or live HZ vaccine (two doses or one dose, respectively). Vaccine efficacy declines with age, live HZ vaccine is contraindicated in immunosuppressed individuals, and severe local reactogenicity of recombinant HZ vaccine is seen in up to 20% of older adults, indicating a potential need for new vaccines. Nonreplicating chimpanzee adenovirus (ChAd) vectors combine potent immunogenicity with well-established reactogenicity and safety profiles. We evaluated the cellular and humoral immunogenicity of ChAdOx1 encoding VZV envelope glycoprotein E (ChAdOx1-VZVgE) in mice using IFN-γ ELISpot, flow cytometry with intracellular cytokine staining, and ELISA. In outbred CD-1 mice, one dose of ChAdOx1-VZVgE (1 × 107 infectious units) elicited higher gE-specific T cell responses than two doses of recombinant HZ vaccine (1 µg) or one dose of live HZ vaccine (1.3 × 103 plaque-forming units). Antibody responses were higher with two doses of recombinant HZ vaccine than with two doses of ChAdOx1-VZVgE or one dose of live HZ vaccine. ChAdOx1-VZVgE boosted T cell and antibody responses following live HZ vaccine priming. The frequencies of polyfunctional CD4+ and CD8+ T cells expressing more than one cytokine (IFN-γ, TNF-α and IL-2) were higher with ChAdOx1-VZVgE than with the conventional vaccines. Results were similar in young and aged BALB/c mice. These findings support the clinical development of ChAdOx1-VZVgE for prevention of HZ in adults aged 50 years or over, including those who have already received conventional vaccines.