Miracle-dz/UniFAR-FTUs huggingface dataset:
Pharmacogenetics Role of Genetic Variants in Immune-Related Factors: A Systematic Review Focusing on mCRC

Pharmacogenetics plays a key role in personalized cancer treatment. Currently, the clinically available pharmacogenetic markers for metastatic colorectal cancer (mCRC) are in genes related to drug metabolism, such as DPYD for fluoropyrimidines and UGT1A1 for irinotecan. Recently, the impact of host variability in inflammatory and immune-response genes on treatment response has gained considerable attention, opening innovative perspectives for optimizing tailored mCRC therapy. A literature review was performed on the predictive role of immune-related germline genetic biomarkers on pharmacological outcomes in patients with mCRC. Particularly, that for efficacy and toxicity was reported and the potential role for clinical management of patients was discussed. Most of the available data regard therapy effectiveness, while the impact on toxicity remains limited. Several studies focused on the effects of polymorphisms in genes related to antibody-dependent cellular cytotoxicity (FCGR2A, FCGR3A) and yielded promising but inconclusive results on cetuximab efficacy. The remaining published data are sparse and mainly hypothesis-generating but suggest potentially interesting topics for future pharmacogenetic studies, including innovative gene–drug interactions in a clinical context. Besides the tumor immune escape pathway, genetic markers belonging to cytokines/interleukins (IL-8 and its receptors) and angiogenic mediators (IGF1) seem to be the best investigated and hopefully most promising to be translated into clinical practice after validation.
Centrifugally driven winds from protostellar accretion discs - I. Formulation and initial results

CAN acknowledges support by an Australian Postgraduate Award. CF gratefully acknowledges funding by the Australian Research Council’s Discovery Projects (grant DP150104329 and DP170100603). CF thanks for high performance computing resources provided by the Leibniz Rechenzentrum and the Gauss Centre for Supercomputing (grants pr32lo, pr48pi and GCS Large-scale project 10391), the Partnership for Advanced Computing in Europe (PRACE grant pr89mu), the Australian National Computational Infrastructure (grant ek9) and the Pawsey Supercomputing Centre with funding from the Australian Government and the Government ofWestern Australia, in the framework of the National Computational Merit Allocation Scheme and the ANU Allocation Scheme. This research was supported by ARC grant No. DP120101792.
NuSTAR reveals that the heavily obscured nucleus of NGC 2785 was the contaminant of IRAS 09104+4109 in the BeppoSAX/PDS hard X-rays

Context. The search for heavily obscured active galactic nuclei has been revitalized in the last five years by NuSTAR, which has provided a good census and spectral characterization of a population of such objects, mostly at low redshift, thanks to its enhanced sensitivity above 10 keV compared to previous X-ray facilities, and its hard X-ray imaging capabilities. Aims. We aim at demonstrating how NGC 2785, a local (z = 0.009) star-forming galaxy, is responsible, in virtue of its heavily obscured active nucleus, for significant contamination in the non-imaging BeppoSAX/PDS data of the relatively nearby (≈17′) quasar IRAS 09104+4109 (z = 0.44), which was originally mis-classified as Compton thick. Methods. We analyzed ≈71 ks NuSTAR data of NGC 2785 using the MYTorus model and provided a physical description of the X-ray properties of the source for the first time. Results. We found that NGC 2785 hosts a heavily obscured (NH ≈ 3 × 1024 cm−2) nucleus. The intrinsic X-ray luminosity of the source, once corrected for the measured obscuration (L2−10keV ≈ 1042 erg s−1), is consistent within a factor of a few with predictions based on the source mid-infrared flux using widely adopted correlations from the literature. Conclusions. Based on NuSTAR data and previous indications from the Neil Gehrels Swift Observatory (BAT instrument), we confirm that NGC 2785, because of its hard X-ray emission and spectral shape, was responsible for at least one third of the 20–100 keV emission observed using the PDS instrument onboard BeppoSAX, originally completely associated with IRAS 09104+4109. Such emission led to the erroneous classification of this source as a Compton-thick quasar, while it is now recognized as Compton thin.
Global and Regional Scale Precipitation Patterns Associated with the El Niño/Southern Oscillation

Abstract We investigate the “typical” global and large-scale regional precipitation patterns that are associated with the El Nino/Southern Oscillation (ENSO). Monthly precipitation time series from over 1700 stations are analyzed using an empirical method designed to identify regions of the globe that have precipitation variations associated with ENSO. Monthly mean ranked precipitation composites are computed over idealized 2-year ENSO episodes for all stations that include data for at least five ENSOs. The amplitude and phase of the Arm harmonic fitted to the 24-month composite values are plotted in the form of a vector for each station. When plotted on a global map, these vectors reveal both the regions of spatially coherent ENSO-related precipitation and the phase of this signal in relation to the evolution of the composite episode. Time cries of precipitation for the coherent regions identified in the harmonic vector map are examined to determine the magnitudes of the ENSO-related precipitation and th.
The RMS survey: Ammonia mapping of the environment of young massive stellar objects – II★

We present the results from NH3 mapping observations towards 34 regions identified by the Red MSX Source (RMS) survey. We have used the Australia Telescope Compact Array to map ammonia (1, 1) and (2, 2) inversion emission spectra at a resolution of 10 arcsec with velocity channel resolution of 0.4 km s−1 towards the positions of embedded massive star formation. Complementary data have been used from the ATLASGAL and GLIMPSE Legacy Surveys in order to improve the understanding of the regions and to estimate physical parameters for the environments. The fields have typical masses of ∼1000 M⊙, radii of ∼0.15 pc, and distances of ∼3.5 kpc. Luminosities range between ∼103 and ∼106 L⊙ and kinetic temperatures between 10 and 40 K. We classify each field into one of two subsets in order to construct an evolutionary system for massive star formation in these regions based on the morphology and relative positions of the NH3 emission, RMS sources, and ATLASGAL thermal dust emission. Differences in morphology between NH3 emission and ATLASGAL clumps are shown to correspond to evolutionary stages of ongoing massive star formation in these regions. The study has been further refined by including the positions of known methanol and water masers in the regions to gain insight into possible protostellar regions and triggered star formation.
Comparison of Blood Cells Parameters and Complete Blood Count in Diabetic Patients: A Cross-sectional Study

Background and Aim: Diabetes is a type of metabolic disorder characterized by increased blood glucose, which is due to insulin resistance, insulin deficiency, or both. Changes in blood cell parameters in diabetes are controversial. The present study aimed to assess the blood cell parameters in diabetic patients compared to healthy individuals. Methods: This cross-sectional study was performed on 540 cases (270 diabetic patients and 270 healthy individuals) over 20 years old who were referred to the clinics affiliated to Semnan University of Medical Sciences, Semnan, Iran, in 2018. The complete blood count (CBC) parameters were assessed in both groups, and demographic information was also collected via questionnaires. All the analyses were performed in SPSS software (version 22). Results: In terms of gender, the majority of participants (61.2%) were female. The white blood cell (WBC) count in diabetic patients was significantly higher than that in the control group (P<0.001), and the hemoglobin (HGB) level was significantly lower in diabetic patients (P=0.009). There was no significant difference in the level of other indices between diabetic and control groups. There was a significant difference between the gender of diabetic patients in HGB, red blood cell (RBC) count, and platelets (PLT) (P<0.001). Moreover, HBG and RBC were less in patients with longer diabetes duration (P<0.001). Conclusion: The obtained results pointed to a statistically significant difference in some hematological parameters of diabetic patients compared to non-diabetic individuals. More studies are needed to clarify the causal relationship between diabetes and these indices.
Discovery of Two Small High-velocity Compact Clouds in the Central 10 pc of Our Galaxy

We discovered two small high-velocity compact clouds (HVCCs) in the HCN J = 4–3 and J = 3–2 maps of the central 20 pc of our Galaxy. Both HVCCs have broad velocity widths ( km s−1) and compact sizes ( ), and originate from the dense molecular clouds in the position–velocity space. One of them has a faint counterpart in a Paschen-α image. Their spatial structure, kinematics, and absence of luminous stellar object are compatible with the notion that each of the small HVCCs is driven by the plunge of an invisible compact object into a molecular cloud. Such objects are most likely inactive, isolated black holes.
Spontaneous CPT Violation and Quantum Anomalies in a Model for Matter–Antimatter Asymmetry in the Cosmos

We review scenarios of baryogenesis through leptogenesis at early epochs of the universe, in string-inspired minimal extensions of the Standard Model (SM), involving heavy right-handed Majorana neutrinos. Spontaneous violation of CPT symmetry is induced by appropriate (in general, temperature-dependent) backgrounds of the Kalb–Ramond (KR) axion field, which has its origins in the (bosonic) massless string multiplet. As interesting features of the model, we also discuss two issues associated with quantum (chiral) anomalies: (i) the non-contribution of the KR axion background to the (anomalous) chiral magnetic effect, which arises in the presence of external electromagnetic fields and non-zero chiral chemical potentials of charged fermions; and (ii) the potential role of quantum fluctuations of the KR axion on the (anomalous) radiative generation of a Majorana mass for the right-handed neutrinos themselves.
POLOIDAL FLOW DRIVEN BY ION-TEMPERATURE-GRADIENT TURBULENCE IN TOKAMAKS

We show that linear collisionless processes do not damp poloidal flows driven by ion-temperature-gradient (ITG) turbulence. Since these flows play an important role in saturating the level of the turbulence, this level, as well as the transport caused by ITG modes, may be overestimated by gyrofluid simulations, which employ linear collisionless rotation damping. {copyright} {ital 1998} {ital The American Physical Society}
The Role of Twist in Kinked Flux Rope Emergence and Delta-spot Formation

It has been observationally well established that the magnetic configurations most favorable for producing energetic flaring events reside in δ-spots, a class of sunspots defined as having opposite-polarity umbrae sharing a common penumbra. They are frequently characterized by extreme compactness, strong rotation, and anti-Hale orientation. Numerous studies have shown that nearly all of the largest solar flares originate in δ-spots, making the understanding of these structures a fundamental step in predicting space weather. Despite their important influence on the space environment, surprisingly little is understood about the origin and behavior of δ-spots. In this paper, we perform a systematic study of the behavior of emerging flux ropes to test a theoretical model for the formation of δ-spots: the kink instability of emerging flux ropes. We simulated the emergence of highly twisted, kink-unstable flux ropes from the convection zone into the corona, and we compared their photospheric properties to those of emerged weakly twisted, kink-stable flux ropes. We show that the photospheric manifestations of the emergence of highly twisted flux ropes closely match the observed properties of δ-spots, and we discuss the resulting implications for observations. Our results strongly support and extend previous theoretical work that suggested that the kink instability of emerging flux ropes is a promising candidate to explain δ-spot formation, as it reproduces their key characteristics very well.
Inducing fear using acoustic stimuli—A behavioral experiment on moose (Alces alces) in Sweden

Abstract Prey species may display anti‐predatory behavior, i.e., flight, increased vigilance, and decreased feeding, in response to the true presence of a predator or to the implied presence of a predator through, e.g., acoustic cues. In this study, we investigated the anti‐predatory reactions of moose (Alces alces) to acoustic stimuli related to hunting, at saltlick stones, a known attractant. In before‐during‐after‐control‐impact experiments, we compared the behavioral responses of individuals to: (i) two hunting‐related acoustic stimuli—hunting dog barking and human speaking; (ii) nonpredatory acoustic stimuli—bird sounds and; and (iii) no acoustic stimulus (control). We asked: (1) How does the probability of moose leaving the site differ depending on the stimulus they are exposed to? ; (2) What affect do the acoustic stimuli have on the amount of time moose spend vigilant, feeding, or away from the site? ; and (3) What affect do the stimuli have on the time between events at a site? We found that when exposed to the human stimulus, moose left the sites in 75% of the events, which was significantly more often compared to the dog (39%), bird (24%), or silent (11%) events. If moose did not leave the site, they spent more time vigilant, and less time feeding, particularly when exposed to a dog or human stimulus. Furthermore, moose spent the most time away from the site and took the longest to visit the site again after a human stimulus. Moose were also more likely to leave the site when exposed to the bird stimulus than during silent controls. Those that remained spent more time vigilant, but their behaviors returned to baseline after the bird stimulus ended. These findings suggest that acoustic stimuli can be used to modify the behavior of moose; however, reactions towards presumably threatening and nonthreatening stimuli were not as distinct as we had expected.
Measurements of the Higgs boson mass and width in the four-lepton final state and electron reconstruction in the CMS experiment at the LHC

This thesis document reports measurements of the mass and width of the new boson re- cently discovered at the Large Hadron Collider (LHC), candidating to be the Standard Model Higgs boson. The analysis uses proton-proton collision data recorded by the Compact Muon Solenoid (CMS) detector at the LHC, corresponding to integrated luminosities of 5.1 fb−1 at 7 TeV center of mass energy and 19.7 fb−1 at 8 TeV center of mass energy. Set of events selecting Higgs boson via the H → Z Z decay channel, where both Z bosons decay to electron or muon lepton pairs, is used for the Higgs boson properties measurements. A precise measurement of its mass has been performed and gives 125.6 ± 0.4(stat) ± 0.2 (syst) GeV. Constraints on the Higgs boson width were established using its off-shell production and decay to a pair of Z bosons, where one Z boson decays to an electron or muon pair, and the other to an electron, muon, or neutrino pair. The obtained result is an upper limit on the Higgs boson width of 22 MeV at a 95% confidence level, which is 5.4 times the expected value in the standard model at the measured mass. Throughout the thesis, a particular attention has been put on the elec- tron momentum estimation. The combination of the momentum estimate with the tracker and the energy measurement with the electromagnetic calorimeter, allowing a significant improvement of the low transverse impulsion electrons measurement of the momentum, has been revisited and played an essential role in the Higgs boson discovery in the 4 leptons decay channel. The electron energy scale and resolution have been measured with very high precision using the Z boson decaying in electrons.
What Powers Ultraluminous IRAS Galaxies?

We present an ISO SWS and ISOPHOT-S, mid-infrared spectroscopic survey of 15 ultraluminous IRAS galaxies (LIR ≥ 1012 L☉). We combine the survey results with a detailed case study, based on arcsecond resolution, near-IR, and millimeter imaging spectroscopy, of one of the sample galaxies (UGC 5101). We compare the near- and mid-IR characteristics of these ultraluminous galaxies to ISO and literature data of 30 starburst and active galactic nuclei (AGN) template galaxies. We find the following: 1. Of the ultraluminous IRAS galaxies in our sample, 70%-80% are predominantly powered by recently formed massive stars, and 20%-30% are powered by a central AGN. These conclusions are based on a new infrared "diagnostic diagram" involving the ratio of high- to low-excitation mid-IR emission lines on the one hand, and the strength of the 7.7 μm PAH feature on the other hand. 2. At least half of the sources probably have simultaneously an active nucleus and starburst activity in a 1-2 kpc diameter circumnuclear disk/ring. 3. The mid-IR emitting regions are highly obscured [Av(screen) ~ 5-50 or Av(mixed) ~ 50-1000]. In a model where star-forming regions and dense molecular clouds are fully mixed, the ISO-derived, V-band dust extinctions approach the dust column densities inferred from CO millimeter measurements. After correction for these extinctions, we estimate that the star-forming regions in ultraluminous infrared galaxies have ages between 107 and 108 yr, similar to but somewhat larger than those found in lower luminosity starburst galaxies. 4. In the sample we have studied there is no obvious trend for the AGN component to dominate in the most compact, and thus most advanced mergers. Instead, at any given time during the merger evolution, the time-dependent compression of the circumnuclear interstellar gas, the accretion rate onto the central black hole, and the associated radiation efficiency may determine whether star formation or AGN activity dominates the luminosity of the system.
A unified constitutive approach for creep response of AISI 316 steel produced by conventional technologies or additive manufacturing techniques

ABSTRACT The creep response of AISI 316 and AISI 316 L was analysed to provide a coherent picture of the material behaviour, valid for both conventional wrought and additively manufactured steels. Literature evidences were considered. The analysis demonstrated that the presence of a fine distribution of particles, precipitated during creep exposure in both AISI 316 and 316 L(N), should be taken into account. A recent model, expressly developed for particle-strengthened alloys, was successfully used to describe the minimum creep rate dependence on applied stress for AISI 316 and 316 L(N). The same set of constitutive equations, in combination with the composite model, was then used for describing creep data obtained by testing the AISI 316 L produced by additive manufacturing. The main difference with wrought materials was that the microstructure of the additively manufactured alloy was composed by cells (soft zones) and thick walls heavily decorated with ultrafine oxide particles (hard zones).
Raman phonons in the ferroelectric-like metal LiOsO 3

The novel ferroelectric-like structural transition observed in metallic ${\text{LiOsO}}_{\text{3}}$ [Y. Shi et al., Nat. Mater. 12, 1024 (2013)], has invoked many theoretical and experimental interests. In this work, we have performed polarized and temperature-dependent Raman scattering measurements on high-quality single crystal ${\text{LiOsO}}_{\text{3}}$ and identified Raman-active modes in both centrosymmetric phase (300 K, $R\overline{3}c)$ and noncentrosymmetric phase (10 K, $R3c)$. Only four phonon peaks are observed in the former phase, while there are 12 peaks in the latter phase because of the reduction of crystal symmetry. With the help of careful symmetry analysis and first-principles calculations, we can make a systematic assignment for the observed Raman modes in both phases. The significant changes in linewidth and the continuous evolution of Raman frequencies with temperatures were observed for the ${E}_{g}$ modes around the transition temperature, which suggests that the ferroelectric-like structural transition is a continuous order-disorder transition. The result sheds light on the coexistence of ferroelectricity and metallicity in the compound.
Equilibrium coordination tests among children: A feasibility study

Introduction: Normative reference scores have not been established for most equilibrium coordination tests. Hence, the aim of the present study was to confirm the feasibility of the methodology and procedures, and limitations, for of large-scale studies establishing normative reference scores for sideways walking, tandem walking, cross-stepping, heel walking and toe walking among children. Material and methods: In this cross-sectional study, 284 children (144 boys and 140 girls) aged 8-15 years were recruited from a senior secondary school to perform five equilibrium coordination tests. The children were asked to perform all tests in a random order, and the time taken in seconds (s) was recorded. The mean values were subjected to statistical analysis. The normality of the data was assessed with the Kolmogorov Smirnov test. The descriptive statistics are presen-ted as geometric mean (GM) and 95% confidence interval (CI). Results: The age, weight, height, and body mass index of the recruited children were 11.1 ± 2.1 years, 37.9 ± 9. kg, 141.3 ± 10.7 cm, and 18.7 ± 3.1 kg/m 2 respectively. The normative data of the trial for sideways walking, tandem walking, cross stepping, heel walking, and toe walking were 23.7 ± 8.8 s, 37.7 ± 6.7 s, 33.9 ± 11.3 s, 18.6 ± 8.8 s, and 14.5 ± 11.2 s, respectively. Conclusions: The findings indicate that it is feasible to conduct a large-scale study with a larger sample population to allow the data to be generalized to the global population.
The X-ray continuum time-lags and intrinsic coherence in AGN

We present the results from a systematic analysis of the X-ray continuum (`hard') time-lags and intrinsic coherence between the $2-4\,\mathrm{keV}$ and various energy bands in the $0.3-10\,\mathrm{keV}$ range, for ten X-ray bright and highly variable active galactic nuclei (AGN). We used all available archival \textit{XMM-Newton} data, and estimated the time-lags following Epitropakis \& Papadakis (2016). By performing extensive numerical simulations, we arrived at useful guidelines for computing intrinsic coherence estimates that are minimally biased, have known errors, and are (approximately) Gaussian distributed. Owing to the way we estimated the time-lags and intrinsic coherence, we were able to do a proper model fitting to the data. Regarding the continuum time-lags, we are able to demonstrate that they have a power-law dependence on frequency, with a slope of $-1$, and that their amplitude scales with the logarithm of the light-curve mean-energy ratio. We also find that their amplitude increases with the square root of the X-ray Eddington ratio. Regarding the intrinsic coherence, we found that it is approximately constant at low frequencies. It then decreases exponentially at frequencies higher than a characteristic `break frequency. ' Both the low-frequency constant intrinsic-coherence value and the break frequency have a logarithmic dependence on the light-curve mean-energy ratio. Neither the low-frequency constant intrinsic-coherence value, nor the break frequency exhibit a universal scaling with either the central black hole mass, or the the X-ray Eddington ratio. Our results could constrain various theoretical models of AGN X-ray variability.