Miracle-dz/UniFAR-FTUs huggingface dataset:
Intimate Partner Violence and Mental Health Outcomes Among Hispanic Women in the United States: A Scoping Review

Hispanic women in the United States experience disproportionate mental health impacts of intimate partner violence (IPV). Following the preferred reporting items for systematic reviews and meta-analyses extension for scoping reviews guidelines, we synthesized the existing knowledge based on IPV and mental health outcomes among Hispanic women in the United States. In May 2020, we searched five electronic databases (i.e., MEDLINE, PILOTS, PSYCInfo, PSYCArticles, and EMBASE). From the initial 1,180 results, 13 articles met inclusion criteria for this review (written in English, empirical study, focus on the experiences of victimization from an intimate partner, focus on mental health outcomes occurring in the person experiencing IPV, included women who identify as Hispanic, and included participants residing in the United States), representing 4,060 women. Findings highlighted significant positive associations between IPV (n = 13; 4,060 women) and general mental health outcomes (n = 4; 759 women) as well as the specific outcomes of depression (n = 12; 2,661 women), anxiety (n = 1; 274 women), post-traumatic stress disorder (n = 3; 515 women), and substance misuse (n = 2; 1,673 women) among Hispanic women in the United States. Limitations included heterogeneity across Hispanic populations and methodological differences between studies. Key avenues for future research were identified, including the need to examine mental health outcomes understudied in relation to IPV among Hispanic women (e.g., personality, obsessive-compulsive, and eating disorders) and to identify cultural and demographic factors (e.g., nativity status, level of acculturation) that may influence relations between IPV and mental health outcomes among Hispanic women. Such research can inform prevention and intervention efforts aimed at improving mental health among Hispanic women in the Untied States experiencing IPV.
Healthcare professionals’ and budtenders’ perceptions of perinatal cannabis use

ABSTRACT Background: While national guidelines state that cannabis should not be consumed during pregnancy, cannabis use during pregnancy continues to increase. Pregnant individuals have reported using healthcare professionals and budtenders (i.e., cannabis store retailers) as resources for information on cannabis use during pregnancy and postpartum. Objectives: To determine healthcare professionals’ and budtenders’ perceptions of risks and benefits of perinatal cannabis use. Method: A qualitative study, using semi-structured, open-ended questions, was conducted with ten healthcare professionals (predominantly nurses; 100% women) and ten budtenders (70% women) in a state where cannabis use is legal for adults 21 years of age and older. Data were interpreted using a qualitative description methodology to identify themes. Themes were generated from participant responses (implicit and explicit). We analyzed data separately and sequentially and present linked themes across samples. Data saturation, rigor, and trustworthiness were discussed and agreed upon by the analytic team. Results: Six themes arose from the healthcare professional and budtender data: 1) Perinatal customers and patients perceive cannabis to be medicinal, 2) Supporting perinatal people who use cannabis, 3) Spectrum of perceived impacts of perinatal cannabis use, 4) Comparison to use of other substances during pregnancy, 5) Perceived limited knowledge and training about cannabis regulation and product safety, and 6) Current trends of purchase and use. Conclusion: Participants reported that perinatal patients/customers perceived cannabis to be medicinal, and highlighted non-judgmental/harm reduction strategies for engaging patients/customers. Training is needed for healthcare professionals and budtenders to assist with patient/customer discussions about perinatal cannabis use.
Serum Neudesin Levels in Obese Adolescents

Objective: Advances in knowledge of neurotrophic factors are now revealing the complex control of energy homeostasis and appetite, as well as the crucial role these factors play in nervous system function. The aim of this study was to assess serum levels of neudesin in adolescents with obesity and to examine the relationship between these levels and metabolic outcomes. Methods: Adolescents, aged 10-17 years were enrolled. Subjects were divided into normal weight, obese and morbidly obese subgroups. Serum neudesin concentrations were compared between the groups. Results: In total, 88 adolescents were recruited, of whom 30 (34.1%) were normal weight, 15 (17.0%) were obese and 43 (48.9%) were morbidly obese. Neudesin levels were significantly lower in obese adolescents than in the control group (p=0.013). A correlation analysis applied to the whole study group revealed a negative correlation between serum neudesin concentration and body mass index (BMI) z scores (r=-0.40, p<0.001). Serum neudesin levels tended to increase in adolescents with metabolic syndrome, insulin resistance, dyslipidaemia, and hypertension but the differences were not significant (p=0.259, p=0.246, p=0.259, and p=0.523, respectively). Conclusion: Serum neudesin levels were significantly correlated with BMI z score in obese adolescents. Generally, serum neudesin levels were low in obese and morbidly obese adolescents and tended to increase with the appearance of metabolic disorders. Both obesity and associated metabolic disorders have multifactorial causes. Therefore, we suggest that the role of the neudesin molecule in the regulatory mechanisms of obesity and metabolic disorders should be further investigated with well-designed studies enrolling larger groups.
The RETREAT score provides valid predictions regarding hepatocellular carcinoma recurrence after liver transplantation

Prediction of hepatocellular carcinoma (HCC) recurrence after liver transplantation (LT) with knowledge of explant data is important for guiding post‐LT surveillance and treatment. The RETREAT score was recently introduced for this purpose, but has not been validated outside the USA. In a retrospective single‐center study of 169 consecutive patients undergoing LT in Gothenburg, through 2000–2017 (mean age 57 years, 80% men), there were 34 HCC recurrences during a median 4.6‐year follow‐up. The 5‐year cumulative incidence of HCC recurrence was 0% with RETREAT scores of 0–1 (18%), 11–22% with scores of 2–4 (58%), and 65% with scores of 5–8 (24%). The C‐statistic, as a measure of discrimination for prediction of HCC recurrence was 0.762, 0.664, 0.616, and 0.717, for the RETREAT score, Milan criteria, UCSF criteria, and post‐MORAL criteria. The RETREAT score had no significant impact on patient survival after HCC recurrence (HR 1.00, P = 0.97). In conclusion, the RETREAT score provided valid predictions of post‐LT HCC recurrence in a European setting, with the ability to discriminate between high, intermediate, and low risk for HCC recurrence in a clinically important way. Prognosis after recurrence did not differ according to the RETREAT score in our study.
A qualitative study of mothers’ health literacy related to malnutrition in under 5-year-old children in southern Mozambique

Abstract Objective: To explore mothers’ perceptions of malnutrition and its causes in U-5’s in Mozambique, as well as their ability to recognise, prevent and act on signs of malnutrition. Design: A qualitative exploratory inquiry using focus group discussions and individual interviews analysed using Nutbeam’s health literacy themes. Setting: Manhiça District Hospital in Manhiça, Mozambique. Participants: Mothers of U-5’s (n 53) attending the in- and out-patient paediatric wards. Results: Different malnutrition literacy levels were identified in mothers’ responses. Mothers’ reflections on the causes of malnutrition in U-5’s were more elaborate compared to those of recognition, prevention and treatment strategies. Only severe forms of acute malnutrition were recognised by mothers, while early signs of undernutrition and stunting largely went undetected or unmentioned. Limited knowledge, time and financial resources were mentioned as contributors to suboptimal practices resulting in malnutrition. The district hospital, rather than community resources or local health posts, was indicated as the place mothers would go to seek advice and treatment for malnutrition. All mothers requested additional information on how to prevent and treat malnutrition. Conclusions: The varying literacy levels among mothers, the lack of references to community health workers as a resource in identifying and managing malnutrition, and the identification of poverty and sociocultural conditions as contributors to suboptimal practices indicate the need for in-depth research focused on the social determinants of malnutrition. A more comprehensive understanding of mothers’ health literacy would contribute to the development of holistic programmes aiming to improve community management of malnutrition.
A Multidisciplinary Approach to Improving the Pediatric Discharge Process

Background: A collaborative and multidisciplinary shared responsibility with providing discharge information to pediatric patients/families can support successful reassimilation to life posthospitalization. Problem: An analysis of the current discharge process at an urban pediatric hospital identified variations in discharge practices and instructions. Approach: A multidisciplinary taskforce used the Plan-Do-Study-Act methodology to standardize the discharge process including creating a discharge template, adopting a new education platform, enhancing the electronic health record, and implementing strategies to improve discharge. Outcomes: There was a reduction in 7-day readmission rate from preintervention 4.58 to postintervention for 4 consecutive quarters of 3.92, 4.20, 3.44, and 3.41, respectively. Percentile ranking and top box scores of the patient satisfaction measure of discharge preparation increased from 12th-62nd to 65th-95th percentile postimplementation and 81% to 88%, respectively. Conclusions: A local improvement initiative related to standardization of the discharge process resulted in a reduction in 7-day readmission rate and improved patient satisfaction scores.
The links between sleep duration, obesity and type 2 diabetes mellitus

Global rates of obesity and type 2 diabetes mellitus (T2DM) are increasing globally concomitant with a rising prevalence of sleep deprivation and sleep disorders. Understanding the links between sleep, obesity and T2DM might offer an opportunity to develop better prevention and treatment strategies for these epidemics. Experimental studies have shown that sleep restriction is associated with changes in energy homeostasis, insulin resistance and β-cell function. Epidemiological cohort studies established short sleep duration as a risk factor for developing obesity and T2DM. In addition, small studies suggested that short sleep duration was associated with less weight loss following lifestyle interventions or bariatric surgery. In this article, we review the epidemiological evidence linking sleep duration to obesity and T2DM and plausible mechanisms. In addition, we review the impact of changes in sleep duration on obesity and T2DM.
Anti-Apoptosis and Autophagy Effects of Melatonin Protect Rat Chondrocytes against Oxidative Stress via Regulation of AMPK/Foxo3 Pathways

Objective Emerging evidence has indicated that excessive reactive oxygen species (ROS) have detrimental effects on osteoarthritis (OA). This study aimed to elucidate the effects of melatonin (MT), an antioxidant indolamine secreted from the pineal gland, on chondrocyte senescence and cartilage degeneration, thereby clarifying the underlying mechanisms of ROS-induced OA pathogenesis. Design Hydrogen peroxide (H2O2) was used to induce oxidative stress in rat chondrocytes. ROS levels were evaluated using cytometry and immunofluorescence. Cell viability was detected using the Cell Counting Kit-8 (CCK-8) assay. Western blotting and qPCR (Quantiative Real-Time Polymerase Chain Reaction) were used to examine apoptosis and autophagy. For in vivo experiments, male Sprague-Dawley rats were randomly divided into a sham-operated group, DMM (destabilization of the medial meniscus) surgery group, and surgery groups that received melatonin. Knee joints were collected and stained for histological analysis. Results The data demonstrated that melatonin treatment significantly suppressed H2O2-induced matrix degradation and apoptosis, and maintained mitochondrial redox homeostasis. In addition, an enhancement of autophagic flux was observed through western blotting. These findings corresponded with activation of the AMPK/Foxo3 signaling pathways upon melatonin treatment. Histological staining and transmission electron microscopy (TEM) micrographs also demonstrated that melatonin alleviated cartilage ossification and chondrocyte hypertrophy in vivo. Conclusions Our results indicated that melatonin protected chondrocytes via mitochondrial redox homeostasis and autophagy. The effects of melatonin on senescence may apply to other age-related diseases. Thus, melatonin may have multiple potential therapeutic applications.
The mesoscale organization of syntaxin 1A and SNAP25 is determined by SNARE–SNARE interactions

SNARE proteins have been described as the effectors of fusion events in the secretory pathway more than two decades ago. The strong interactions between SNARE domains are clearly important in membrane fusion, but it is unclear whether they are involved in any other cellular processes. Here, we analyzed two classical SNARE proteins, syntaxin 1A and SNAP25. Although they are supposed to be engaged in tight complexes, we surprisingly find them largely segregated in the plasma membrane. Syntaxin 1A only occupies a small fraction of the plasma membrane area. Yet, we find it is able to redistribute the far more abundant SNAP25 on the mesoscale by gathering crowds of SNAP25 molecules onto syntaxin clusters in a SNARE-domain-dependent manner. Our data suggest that SNARE domain interactions are not only involved in driving membrane fusion on the nanoscale, but also play an important role in controlling the general organization of proteins on the mesoscale. Further, we propose these mechanisms preserve active syntaxin 1A–SNAP25 complexes at the plasma membrane.
Biobank Participants’ Attitudes Toward Data Sharing and Privacy: The Role of Trust in Reducing Perceived Risks

Biobank participants are often unaware of possible uses of their genetic and health information, despite explicit descriptions of those uses in consent forms. To explore why this misunderstanding persists, we conducted semi-structured interviews and knowledge tests with 22 participants who had recently enrolled in a research biobank. Results indicated that participants lacked understanding of privacy and data-sharing topics but were mostly unconcerned about associated risks. Participants described their answers on the knowledge test as largely driven by their trust in the healthcare system, not by a close reading of the information presented to them. This finding may help explain the difficulties in increasing participant understanding of privacy-related topics, even when such information is clearly presented in biobank consent forms.
South Asian (Clade I) Candida auris meningitis in a paediatric patient in Iran with a review of the literature

Candida meningitis is a rare life‐threatening yeast infection mostly involving immunocompromised or paediatric patients undergoing neurosurgical procedures or shunt placement. Due to difficulties in diagnosis because of diverse clinical manifestations, the number of patients affected is most likely underestimated. Therefore, the correct diagnosis may be delayed for months, and accurate species identification is highly recommended for administering appropriate antifungal therapy. We report the first case of fluconazole‐resistant Candida auris meningitis in a paediatric patient in Iran. This strain was probably imported, as it genotypically belonged to Clade I from South Asia. Furthermore, we include a literature review of C auris meningitis cases, as the number of cases with C auris meningitis has increased with reports from the United Kingdom, India and Iran. This problem might increase further in the era of COVID‐19 due to attrition of experienced healthcare personnel and a high workload of hospital healthcare workers. To understand the precise prevalence of this emerging multidrug resistance pathogen, epidemiological surveillance studies are urgently warranted.
The Association between Immediate Postpartum Depot Medroxyprogesterone Acetate Use and Postpartum Depressive Symptoms

Abstract Objective While postpartum depot medroxyprogesterone acetate (DMPA) is a highly effective form of contraception, some data suggest an association with depressive symptoms. Our objective was to evaluate the relationship between receipt of DMPA in the immediate postpartum period and postpartum depressive symptoms. Study Design This retrospective cohort study included all women who received prenatal and postpartum care at academic obstetric clinics affiliated with a tertiary care institution between January 1, 2008 and December 31, 2014. All women were counseled on contraception prior to hospital discharge. DMPA was available in the hospital pharmacy, and its utilization was documented in the electronic health record. The Patient Health Questionnaire 9 (PHQ-9) was used to screen for postpartum depression for all women at all postpartum visits. A score of 10 or greater was categorized as positive. Bivariable and multivariable analyses were used to identify the association between immediate postpartum DMPA use and a positive postpartum depression screen. Results Of the 5,073 women who met inclusion criteria, 410 (8.1%) received DMPA prior to hospital discharge. Compared with women who did not receive DMPA, women who received DMPA prior to hospital discharge were younger, more likely to identify as Black race or Latinx ethnicity, and more likely to be publicly insured. Clinical characteristics also differed. Women who received DMPA were more likely to be obese and to have experienced prenatal depressive symptoms, been diagnosed with a hypertensive disorder of pregnancy, delivered preterm, and delivered vaginally. Receipt of immediate postpartum DMPA was not associated with having a positive screen for postpartum depression in bivariable (5.4 vs. 6.0%, p = 0.29) or multivariable (adjusted odds ratio 0.94, confidence interval 0.53–1.68) analyses. Conclusion Receipt of postpartum DMPA is not associated with a positive postpartum PHQ-9 screen. Concerns about precipitating postpartum depression should not preclude the utilization of DMPA as a contraceptive agent. Key Points Contraception is an important issue for obstetricians to address with postpartum patients. Concerns have been raised over the relationship between DMPA and depression. Our study shows that DMPA is not associated with a positive postpartum depression screen.
Evolution of phenotypic variance in response to a novel hot environment

Shifts in trait means are widely considered as evidence for adaptive responses, but the impact on phenotypic variance remains largely unexplored. Classic quantitative genetics provides a theoretical framework to predict how selection on phenotypic mean affects the variance. In addition to this indirect effect, it is also possible that the variance of the trait is the direct target of selection, but experimentally characterized cases are rare. Here, we studied gene expression variance of Drosophila simulans males before and after 100 generations of adaptation to a novel hot laboratory environment. In each of the two independently evolved populations, the variance of 125 and 97 genes was significantly reduced. We propose that the drastic loss in environmental complexity from nature to the lab may have triggered selection for reduced variance. Our observation that selection could drive changes in the variance of gene expression could have important implications for studies of adaptation processes in natural and experimental populations.
KAYSERİ'DEKİ ÖZEL İŞLETMELERDE YETİŞTİRİLEN SİMMENTAL SIĞIRLARIN DÖL VERİMİ ÖZELLİKLERİ ÜZERİNDE ARAŞTIRMALAR

OZET Bu calisma, Almanya'dan ithal edilerek Kayseri'deki ozel isletme kosullarinda yetistirilen Simmental sigirlarin dol verimi ozelliklerine iliskin duzeylerin belirlenmesi amaciyla yapilmistir. Arastirma farkli isletmelerde yurutuldugunden, hayvanlara ortak bir bakim ve besleme programi uygulanmamistir. Verilerin istatistik analizlerinde, oransal degerlerde x2-testi, gruplardaki ortalama degerlerin karsilastirilmasinda Duncan testi, SAS program paketindeki GLM proseduru kullanilarak yapilmistir. Calismadaki Simmental sigirlarda %96.0 gebelik saglanmis, gebe kalan sigirlarda abort gorulmemis ve %4.2 ikizlik belirlenmistir. Arastirmada ilk gebelik yasi 20.67 ay, ilk buzagilama yasi 29.98 ay, bir gebelik icin tohumlama sayisi 1.94, gebelik suresi 282.55 gun, acik periyod 95.49 gun, buzagilama araligi 377.74 gun olarak bulunmustur. Calismadaki sigirlara ait dol verimlerinin genellikle standart degerler duzeyinde oldugu belirlenmistir. Anahtar Kelimeler: Simmental, Kayseri, dol verimi. RESEARCHES ON THE REPRODUCTIVE CHARACTERISTICS OF SIMMENTAL CATTLE IN COMMERCIAL FARMS IN KAYSERI ABSTRACT The study was carried out to investigate the reproductive characteristics of Simmental cattle which were imported from Germany and raised in commercial farm conditions in Kayseri. As the study was conducted in various farms a common care and feeding program could not be applied. In the statistical analysis of data, x2-test for ratios, Duncan-test for the comparisons of mean values in groups of these data were used in GLM procedure in SAS program. In the Simmental cattle in the study gestation rate was 96.0%; no abortion was observed and twinning rate was 4.2%. First gestation and calving age was 20.67 and 29.98 months, number of inseminations was 1.94, gestation length was 282.55 days, open period was 95.49 days, calving interval was 377.74 days. The reproductive results of the cows in the present study were at standard levels. Key Words: Simmental, Kayseri, reproductive performance.
Modulating response of Zea mays to induced salinity stress through application of nitrate mediated silver nanoparticles and indole acetic acid

Nanotechnology has been amplified in different areas of science as well as agriculture in the present era. So, the present work was designed to evaluate the result of nitrate mediated silver nanoparticles (Nit‐AgNPs) and indole acetic acid (IAA) on physio‐biochemical features of the selected maize variety (Pahari white) under 40 and 80 mM salinity induction. Seeds were propagated in triplicates in earthen pots (18 cm inferior and superior inside diameter, 20 cm stature, and 2 cm breadth) filled with silt and soil (1:2) having 3.09–5.12 Electrical conductivity (EC), 6.8–7.3 pH, and 4–16% moisture contents. Scanning electron microscopy results showed the average particle size around 90 nm indicating a high surface area suitable for adsorption properties, agglomerated, roughly spherical, and were uniformly dispersed. Elemental quantification of biosynthesized AgNPs analyzed via energy dispersive X‐ray spectroscopy showed a strong peak at 3.0 KeV along with the presence of elements K, N, O, and C. Results of Thermo‐gravimetric Analysis (TGA)/Differential Thermal Analysis (DTA) showed endothermic major decline at 150–300°C, while exothermic peak at 300–400°C. The growth responses at 40 mM salinity concentration have been reduced representing from the least boundary of chlorophyll “a,” “b,” and peroxidase content, whereas; this adverse effect has been reduced by operation of Nit‐AgNPs as separate treatment and in combination with IAA. From the current study, it has been concluded that salinity concentration at 80 mM adversely affected the values of osmolytes, protein, and superoxide dismutase whereas the maximum amplitude of proline reduced by the application of Nit‐AgNPs as distinct treatment indicating that the plant behaves normal with the combined application of nanoparticles and IAA.