Miracle-dz/UniFAR-FTUs huggingface dataset:
A Willingness to Disclose Personal Information for Monetary Reward: A Study of Fitness Tracker Users in Thailand

The paper investigates a person’s willingness to reveal personal information for a monetary reward using a model that includes factors reflecting trust belief, risk belief, information type, subjective norm, and privacy concerns. A survey of fitness-tracker users (N = 504) using a convenience sampling approach allowed data to be collected. Data analysis used a measurement model to assess construct reliability and validity, with structural equation modeling (SEM) used to test the model’s hypotheses. Findings highlight the direct effect of information type and subjective norm as factors that influence privacy. Trust and risk belief associated with information disclosure did not affect privacy concerns nor the willingness to disclose for monetary reward. Subjective norm was the only factor associated with people’s willingness to disclose information for monetary reward—highlighting the influence of peer groups and culture on the disclosure process. Notably, subjective norm as a factor that influences information disclosure is seldom reported. The paper contributes to further understanding of factors that influence personal information disclosure when people are offered a monetary incentive. Practical implications include how a reasonable monetary reward can potentially influence disclosure and that leveraging social networks when requesting information may enhance disclosure. Theoretical implications highlight that the modeling of commonly measured risk and trust factors may not hold in certain situations.
Alkaline Soil Degradation and Crop Safety of 5-Substituted Chlorsulfuron Derivatives

Sulfonylurea herbicides can lead to serious weed resistance due to their long degradation times and large-scale applications. This is especially true for chlorsulfuron, a widely used acetolactate synthase inhibitor used around the world. Its persistence in soil often affects the growth of crop seedlings in the following crop rotation, and leads to serious environmental pollution all over the world. Our research goal is to obtain chlorsulfuron-derived herbicides with high herbicidal activities, fast degradation times, as well as good crop safety. On account of the slow natural degradation of chlorsulfuron in alkaline soil, based on the previously reported results in acidic soil, the degradation behaviours of 5-substituted chlorsulfuron analogues (L101–L107) were investigated in a soil with pH 8.39. The experimental data indicated that 5-substituted chlorsulfuron compounds could accelerate degradation rates in alkaline soil, and thus, highlighted the potential for rational controllable degradation in soil. The degradation rates of these chlorsulfuron derivatives were accelerated by 1.84–77.22-fold, compared to chlorsulfuron, and exhibited excellent crop safety in wheat and corn (through pre-emergence treatment). In combination with bioassay activities, acidic and alkaline soil degradation, and crop safety, it was concluded that compounds L104 and L107, with ethyl or methyl groups, are potential green sulfonylurea herbicides for pre-emergence treatment on wheat and corn. This paper provides a reference for the further design of new sulfonylurea herbicides with high herbicidal activity, fast, controllable degradation rates, and high crop safety.
Dynamic Involvement of Telocytes in Modulating Multiple Signaling Pathways in Cardiac Cytoarchitecture

Cardiac interstitium is a complex and dynamic environment, vital for normal cardiac structure and function. Telocytes are active cellular players in regulating main events that feature myocardial homeostasis and orchestrating its involvement in heart pathology. Despite the great amount of data suggesting (microscopically, proteomically, genetically, etc.) the implications of telocytes in the different physiological and reparatory/regenerative processes of the heart, understanding their involvement in realizing the heart’s mature cytoarchitecture is still at its dawn. Our scrutiny of the recent literature gave clearer insights into the implications of telocytes in the WNT signaling pathway, but also TGFB and PI3K/AKT pathways that, inter alia, conduct cardiomyocytes differentiation, maturation and final integration into heart adult architecture. These data also strengthen evidence for telocytes as promising candidates for cellular therapies in various heart pathologies.
Different Effects of RNAi-Mediated Downregulation or Chemical Inhibition of NAMPT in an Isogenic IDH Mutant and Wild-Type Glioma Cell Model

The IDH1R132H mutation in glioma results in the neoenzymatic function of IDH1, leading to the production of the oncometabolite 2-hydroxyglutarate (2-HG), alterations in energy metabolism and changes in the cellular redox household. Although shifts in the redox ratio NADPH/NADP+ were described, the consequences for the NAD+ synthesis pathways and potential therapeutic interventions were largely unexplored. Here, we describe the effects of heterozygous IDH1R132H on the redox system in a CRISPR/Cas edited glioblastoma model and compare them with IDH1 wild-type (IDH1wt) cells. Besides an increase in 2-HG and decrease in NADPH, we observed an increase in NAD+ in IDH1R132H glioblastoma cells. RT-qPCR analysis revealed the upregulation of the expression of the NAD+ synthesis enzyme nicotinamide phosphoribosyltransferase (NAMPT). Knockdown of NAMPT resulted in significantly reduced viability in IDH1R132H glioblastoma cells. Given this dependence of IDH1R132H cells on NAMPT expression, we explored the effects of the NAMPT inhibitors FK866, GMX1778 and GNE-617. Surprisingly, these agents were equally cytotoxic to IDH1R132H and IDH1wt cells. Altogether, our results indicate that targeting the NAD+ synthesis pathway is a promising therapeutic strategy in IDH mutant gliomas; however, the agent should be carefully considered since three small-molecule inhibitors of NAMPT tested in this study were not suitable for this purpose.
Integrated Bioinformatics and Clinical Correlation Analysis of Key Genes, Pathways, and Potential Therapeutic Agents Related to Diabetic Nephropathy

Background Diabetic nephropathy (DN) is a common microvascular complication of diabetes and a major cause of end-stage renal disease, resulting in a substantial socioeconomic burden around the world. Some unknown biomarkers, mechanisms, and potential novel agents regarding DN are yet to be identified. Methods GSE30528 and GSE1009 were downloaded as training datasets to identify differentially expressed genes (DEGs) of DN. Common DEGs were selected for further analysis. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses of DEGs were performed to explore molecular mechanisms and pathways. Protein-protein interaction (PPI) network of DEGs was used to identify the top 10 hub genes of DN. Expression profiles of the hub genes were validated in GSE96804 and GSE47183 datasets. The clinical correlation analyses were conducted to confirm the association between key genes and clinical characteristics in the Nephroseq v5 database. The Drug Gene Interaction Database was used to predict potential targeted drugs. Results 345 and 1228 DEGs were identified in GSE30528 and GSE1009, respectively; and 120 common DEGs were found. The biological process of DEGs was significantly enriched in kidney development. PI3K-Akt signaling pathway, focal adhesion, complement and coagulation cascades were significantly enriched KEGG pathways. The identified top10 hub genes were VEGFA, NPHS1, WT1, TJP1, CTGF, FYN, SYNPO, PODXL, TNNT2, and BMP2. VEGFA, NPHS1, WT1, CTGF, SYNPO, PODXL, and TNNT2 were significantly downregulated in DN. VEGFA, NPHS1, WT1, CTGF, SYNPO, and PODXL were positively correlated with glomerular filtration rate. The targeted drugs or molecular compounds were enalapril, sildenafil, and fenofibrate target for VEGFA; losartan target for NPHS1; halofuginone, deferoxamine, curcumin, and sirolimus target for WT1; and purpurogallin target for TNNT2. Conclusions VEGFA, NPHS1, WT1, CTGF, SYNPO, and PODXL are promising biomarkers for diagnosing and evaluating the progression of DN. The drug-gene interaction analyses provide a list of candidate drugs for the precise treatment of DN.
INFLUENCE OF IN OVO INJECTION WITH VITAMIN D3 ON SOME PHYSIOLOGICAL PARAMETERS AND BONE DEVELOPMENT OF NORFA CHICKS

: This study aimed to assess the effects of in ovo injection with vitamin D 3 on Norfa chick’s performance. All fertile eggs were kept at incubation room temperature for 12 hours and then incubated in a forced draft incubator at 37.8°C with 55 - 60% relative humidity. Eggs were turned every two hours from the 2 nd to 18 th day of incubation. In the 1 st group, 40 eggs were not injected and considered as negative control, while in the 2 nd group, 40 eggs were injected with distilled water (positive control). In the 3 rd and 4 th groups, 160 and 180 eggs were injected with 50 and 100µL vitamin D 3 (VD 3 ), respectively. Eggs were injected on the 18 th day of incubation to deposit test material in the air sac through the wide end of the egg then the hole was closed by wax. During the last 3 days of incubation, all eggs were transferred to a separate hatcher at 36.5°C and 75 -80% relative humidity. At hatch, the chicks were wing-banded, weighed and kept in the brooding house. The results showed that the chicks produced from eggs injected with 100 µL VD 3 exhibited significantly greater live body weight and body weight gain compared to other groups at different ages. Moreover, the feed conversion ratio and embryonic mortality rate were significantly affected during experimental period. The embryonic mortality rate was significantly increased in all treated-groups compared to negative control group. Immune response at 7 days and 28 days for Norfa chicks injected with VD 3 significantly improved compared to control groups. The highest value for femur and sternum bone length was recorded in chicks injected with 100µL VD 3 , while tibia bone length was significantly decreased. Blood AST and ALT levels for chicks injected with 100µL VD 3 significantly increased compared to negative control group. In ovo injected VD 3 of 50 and 100 µL increased total serum calcium compared with the control groups. These results indicated that the in ovo injection of different levels of vitamin D 3 had a significant effect on white blood cells, lymph count, neutrophil, red blood cells and platelets. However, there was no significant effect of the in ovo injection on the levels of hemoglobin and hematocrit. In conclusion, early in ovo injection of different levels of vitamin D 3 might be considered a feasible technique for increasing Norfa chicks performance, hatchability, blood parameters, immunity and decreasing mortality.
BLOOD BIOCHEMICAL AND IMMUNOLOGICAL RESPONSES OF MUSCOVY DUCKLINGS TO EARLY AGE THERMAL MANIPULATION

SUMMARY he main objective of this study was to investigate the beneficial effects of early age epigenetic adaptation of newly hatched ducks on their post hatch growth performance, physiological and blood biochemical changes, along with oxidative stress and immune responses. Total of 200, day old ducklings were brooded at 33 ±1°C for the first three days post hatching, and then were divided into two equal groups (100 chicks each), a control group maintained under the brooding temperature, while the other group was exposed to early age thermal conditioning at 39.5 ±1°C for 4 h at the 4 th , 5 th and 6 th days post hatching. After that both groups were subjected to 30 ±1°C from the 7 th to the 10 th day of age then reduced gradually to reach 24 ±1°C by day 28 of age. From the beginning of the 5 th week of age until the end of the experiment (12 weeks), all birds have similar feeding and managerial conditions. Blood samples were collected after 24 hours of the first exposure time, and again after the last exposure (at 80 days of age). Results showed that LBW and BWG of ducks were significantly (P ≤ 0.05) higher for those exposed to TM compared by those of the control (TN) treatment. Feed consumption was not significantly affected by early age TM; however, the cumulative FC was significantly increased for the heat-exposed ducks. Meanwhile, feed conversion ratio (FCR) was significantly better for the TM- exposed ducks than those of TN ones. Body temperature and respiration rate were significantly decreased at the latter stage of growing period (12 week) by early-age thermal conditioning. Plasma lysozyme activity of Muscovy ducks was insignificantly increased in early heat exposed group compared to the control one. Red blood cells count, hemoglobin level and PCV were significantly increased in TM exposed ducks compared to the TN ones. Plasma thyroid hormones (T3, T4) and corticosterone levels were significantly increased at the end of experiment as a result of thermal conditioning. A similar trend was also observed for the H:L ratio which was the highest in TN birds. Corticosterone and Heterophils: lymphocytes ratio decreased in the thermally manipulated-duckling compared to control group. Plasma MDA was significantly decreased in early heat exposed group compared to the control group. Superoxide dismutase and catalase enzymes increased in TM exposed ducks compared to the control one. It is concluded that a 3 days of early age thermal conditioning could be used as a practical approach to alleviate the negative impact of heat stress at older ages, to improve the antioxidative status and immune responses in growing ducks.
Functional Outcomes in a Randomized Controlled Trial of Animal-Assisted Therapy on Middle-Aged and Older Adults with Schizophrenia

Deficits in cognition, physical, and social functions in adults with schizophrenia may become salient with aging. While animal-assisted therapy (AAT) can benefit physical function in older adults and improve symptoms of psychotic disorders, the effect of AAT on middle-aged patients with schizophrenia is unclear. The current randomized controlled trial aimed to explore the efficacy of AAT for middle-aged patients with schizophrenia. Forty participants were randomly assigned to either the AAT or control group. The AAT group participated in one-hour sessions with dog-assisted group activities once a week for 12 weeks. The controls participated in dose-matched, non-animal-related recreational activities. Both groups remained on their usual psychotropic medication during the trial. Evaluations included the Chair Stand Test (CST), Timed Up-and-Go (TUG) test, Montreal Cognitive Assessment (MoCA), 5-Meter walk test (5MWT), and Assessment of Communication and Interaction Skills (ACIS). The increases in CST repetitions and ACIS scores were larger in the AAT group than in the controls. The two groups did not differ significantly in MoCA scores, TUG performance, or the 5MWT. The AAT group showed a greater increase in lower extremity strength and social skills, but no improvement in cognitive function, agility, or mobility. Further research with more sensitive evaluations and longer follow-up is needed.
Kidney oxygenation, perfusion and blood flow in people with and without type 1 diabetes

ABSTRACT Background We used magnetic resonance imaging (MRI) to study kidney energetics in persons with and without type 1 diabetes (T1D). Methods In a cross-sectional study, 15 persons with T1D and albuminuria and 15 non-diabetic controls (CONs) underwent multiparametric MRI (3 Tesla Philips Scanner) to quantify renal cortical and medullary oxygenation (R2*, higher values correspond to higher deoxyhaemoglobin concentration), renal perfusion (arterial spin labelling) and renal artery blood flow (phase contrast). Analyses were adjusted for age, sex, systolic blood pressure, plasma haemoglobin, body mass index and estimated glomerular filtration rate (eGFR). Results Participants with T1D had a higher median (Q1; Q3) urine albumin creatinine ratio (UACR) than CONs [46 (21; 58) versus 4 (3; 6) mg/g; P < . 0001] and a lower mean ± SD eGFR (73 ± 32 mL/min/1.73 m2 versus 88 ± 15 mL/min/1.73 m2; P = .12), although not significantly. Mean medullary R2* was lower in T1D (34 ± 6/s versus 38 ± 5/s; P < .01) corresponding to a higher oxygenation. R2* was not different in the cortex. Cortical perfusion was lower in T1D (163 ± 40 versus 224 ± 49 mL/100 g/min; P < .001). Renal artery blood flow was lower in T1D than in CONs (360 ± 130 versus 430 ± 113 mL/min; P = .05). In T1D, lower cortical oxygenation and renal artery blood flow were both associated with higher UACR and lower eGFR (P < .05). Conclusions Participants with T1D and albuminuria exhibited higher medullary oxygenation than CONs, despite lower cortical perfusion and renal artery blood flow. This might reflect perturbed kidney energetics leading to a higher setpoint of medullary oxygenation in T1D. Lower cortical oxygenation and renal artery blood flow were associated with higher UACR and lower eGFR in T1D.
The Impact of Residual Dispersant on the Flocculation and Sedimentation of Synthetic Tailings in Seawater

Dispersants under certain conditions favor the flotation of molybdenite in seawater; however, it is not clear if the entrainment of residues to the thickening stage can compromise the quality of the clarified water. In this work, the impact of small concentrations of sodium hexametaphosphate (SHMP) on the flocculation and sedimentation of synthetic tailings containing kaolinite, muscovite, and quartz in seawater is evaluated. The flocculant polymer is a high-molecular-weight polyacrylamide, and the pH is alkaline. The results are auspicious for mineral processing. On the one hand, the impact of SHMP is not entirely negative and can be lessened by limiting entrainment, which is good for copper and molybdenum ore processing. On the other hand, if the small increase in turbidity generated by the SHMP is tolerated, it is possible to expect improved settling speeds. Without SHMP, large but light agglomerates are formed. With SHMP, smaller but denser aggregates are formed, settling faster, and minute aggregates increase turbidity. The underlying mechanism derives from the competition between SHMP and polymer chains for the cations in solution; the result is a greater repulsion between the chains, which leads to greater repulsion and thus dispersion of smaller flocculant coils. The study shows that SHMP in concentrations of 1 to 3 kg/t is perfectly acceptable. The results represent an advance in the understanding of SHMP interactions with polymers and minerals in water clarification, which should be of interest to the industry whose sustainability in some regions depends on closing the water cycle.
Antibacterial Activity of Essential Oils of Inula viscosa against Some Multi-Resistant Pseudomonas aeruginosa ATCC 27853 and Staphylococcus aureus ATCC 25923

worldwide employed as a crude drug by people in the and Due to the development of antimicrobial resistance by the use of antibiotics among pathogenic bacteria, natural products extracted from the plants can be used as alternative strategies to reduce pathogenic bacteria from foods and patients. the extraction of essential oils from the of , an aromatic from the mountainous of of Sidi Bel-Abbes and the evaluation of their antibacterial against some such E. coli, Ps. 27853 , and , subtilus by using agar well diffusion method and by the study of bacterial growth in the and the of oils.
Awareness of Medical Doctors in Pusat Perubatan Universiti Kebangsaan Malaysia on Diagnostic Radiological Examination Related Radiation Exposure in the Pediatric Population

Background: When exposed to equal radiation doses, the risks for children and adolescents are more significant than for adults. Children grow quickly, and their cells are more sensitive to radiation. After radiation exposure, children have a higher risk of developing malignancies such as leukemia, thyroid abnormalities, and various types of cancers. The healthcare professionals’ (in this context referring to medical doctors at all levels) awareness of imaging modalities associated with ionizing radiation is essential to ensure optimal patient management of cooperation in dealing with radiation exposure. Therefore, the present study is aimed to evaluate the awareness of healthcare professionals on medical imaging-related radiation exposure in the pediatric population in our center, Pusat Perubatan Universiti Kebangsaan Malaysia. Materials and Methods: A cross-sectional survey was conducted among healthcare professionals using self-administered validated questionnaires in a university hospital for a duration of seven months. Healthcare professionals of all levels participated in this survey. Results: A total of 145 healthcare professionals participated in this study. More than half of the respondents are house officers, 57.2% (n = 83). Results indicated that only 6 out of 145 healthcare professionals who participated in this survey had attended a radiation protection course. This survey showed that 37.2% of the respondents were unaware that chest radiographs would expose patients to ionizing radiation. Finally, results also indicated that senior doctors (21 out of 24 participants) showed better awareness of radiation protection knowledge. Conclusions: In general, healthcare professionals in our institution are inadequate in awareness of medical radiation exposure, particularly among house officers. However, the awareness of radiation safety and exposure improves with the number of years of clinical practice. We propose that some younger healthcare professionals do not take radiation safety seriously. Moreover, we would like to suggest all healthcare professionals must attend a radiation safety course, as we expect this will improve patient outcomes.
Climate Impacts and Potential Drivers of the Unprecedented Antarctic Ozone Holes of 2020 and 2021

The latter months of 2020 and 2021 were marked by two of the largest Antarctic ozone holes on record. That such large ozone holes occurred despite ongoing ozone recovery raises questions about their origins and climate impacts. Here we provide novel evidence that supports the hypothesis that the ozone holes were influenced by two distinct and extraordinary events: the Australian wildfires of early 2020 and the eruption of La Soufriere in 2021. We further reveal that both ozone holes were associated with widespread changes in Southern Hemisphere climate that are consistent with the established climate impacts of Antarctic ozone depletion, including a strengthening of the polar stratospheric vortex, enhanced surface westerlies over the Southern Ocean, and surface temperature changes over Antarctica and Australia. The results thus provide suggestive evidence that injections of both wildfire smoke and volcanic emissions into the stratosphere can lead to hemispheric‐scale changes in surface climate.