Miracle-dz/UniFAR-FTUs huggingface dataset:
Alexithymia, Prior Trauma, Alcohol Use, and Sexual Aggression Perpetration: A Cross-Cultural Comparison of a Moderated Mediation Model

In this study, we examined the relationships between prior trauma, alexithymia, and sexual aggression perpetration among 610 U.S. college students and 107 college students from the Philippines utilizing a cross-sectional retrospective design. We tested a moderated mediation model with alexithymia as the mediator between prior trauma and sexual aggression perpetration, and alcohol use as a moderator of the alexithymia–sexual aggression link. Moreover, given that cultural norms may influence these relationships, we also examined the structural invariance of the proposed moderated mediation model. Path analyses and multiple group analysis were used to examine the moderated mediation model, and examine model differences between samples. We did not find evidence for alexithymia as a mediator, but there was a significant interaction between alcohol use severity and alexithymia on sexual aggression perpetration across both samples. Alexithymia is a key variable in understanding the alcohol use–sexual aggression perpetration relationship. Clinical implications and recommendations for future research are also discussed.
Prophylactic and Curative Effects of Barley and its Bran Against Hyperlipidemia in Albino Rats

The aim of this study was to investigate the prophylactic and curative effects of barley and it’s bran against hyperlipidemia in albino rats. A total of 88 adult male albino rats “swiss strain” weighting about 80-100g were used in 2 main experiments. (1) The prophylactic effect of barley and bran against hyperlipidemia for 8 weeks and (2) The curative effect of barley and bran for 8 weeks after induction of hyperlipidemia (using cholesterol and cholic acid). The data revealed that there was an increase in the levels of serum total lipids, total cholesterol, triglycerides, ALT, AST, ALP and LDH, while HDL-cholesterol level was decreased after the induction of hyperlipidemia. These results suggest that barley and bran may evoke different lipidaemic responses and that barley bran has more favorable effect on blood lipids than the whole barley. Results were compared with those of Atorvastatin, a standard orally effective hypolipidemic agent. Hyperlipidemia, Prophylactic, Curative, Barley, Bran, Lipid Profile, Liver Function.
Supervision by Registration and Triangulation for Landmark Detection

We present supervision by registration and triangulation (SRT), an unsupervised approach that utilizes unlabeled multi-view video to improve the accuracy and precision of landmark detectors. Being able to utilize unlabeled data enables our detectors to learn from massive amounts of unlabeled data freely available and not be limited by the quality and quantity of manual human annotations. To utilize unlabeled data, there are two key observations: (I) The detections of the same landmark in adjacent frames should be coherent with registration, i.e., optical flow. (II) The detections of the same landmark in multiple synchronized and geometrically calibrated views should correspond to a single 3D point, i.e., multi-view consistency. Registration and multi-view consistency are sources of supervision that do not require manual labeling, thus it can be leveraged to augment existing training data during detector training. End-to-end training is made possible by differentiable registration and 3D triangulation modules. Experiments with 11 datasets and a newly proposed metric to measure precision demonstrate accuracy and precision improvements in landmark detection on both images and video.
Enantiomer specific pharmacokinetics of ibuprofen in preterm neonates with patent ductus arteriosus

Racemic ibuprofen is widely used for the treatment of preterm neonates with patent ductus arteriosus. Currently used bodyweight‐based dosing guidelines are based on total ibuprofen, while only the S‐enantiomer of ibuprofen is pharmacologically active. We aimed to optimize ibuprofen dosing for preterm neonates of different ages based on an enantiomer‐specific population pharmacokinetic model.
Assembly of Short-Chain Amphiphilic Homopolymers into Well-Defined Particles.

Linear homopolymers of norbornene (NBE) derivatives equipped with short-chain alcohol pendent groups were prepared by ring-opening metathesis polymerization (ROMP) and subsequently assembled into well-defined structures in alcohol solvents. The ratios of hydrophobic carbons and hydrophilic alcohol groups at the repeating monomeric unit in these short-chain amphiphilic polymers were found to play an important role in determining the size and distribution of the final globular structures. Unlike the assembly of other linear homo- and co-polymers possessing long-chain amphiphilicity, NBE-based linear polymers are readily transformed into spherical particles with a layered conformation, whose sizes range from a few hundred nanometers to micrometers with narrow distributions, simply by controlling the concentration and molecular weights of the linear homopolymers without using any surfactants. In addition, the degree of the intermolecular forces with solvents (e.g., solvation) possessing different surface tensions and polarities highly affected the final diameter and distribution of the polymer particles, implying the importance of the selection of a proper solvent to regulate their structural features. As such, understanding the assembly of these types of short-chain homopolymers into uniform particles can allow for regulating the transformation of diverse linear amphiphilic polymers into precisely controlled structures for various applications.
Upregulation of Neural Cell Adhesion Molecule 1 (NCAM1) by hsa-miR-141-3p Suppresses Ameloblastoma Cell Migration

Background Neural cell adhesion molecule 1 (NCAM1; CD56) and E-cadherin are both involved in cell-cell adhesion and cell development processes, and their dysregulation is associated with various tumors. We hypothesized that dysregulated NCAM1 could suppress the invasive behavior of ameloblastoma (AB), and its expression was regulated by miR-141-3p. Material/Methods Real-time qPCR was performed to examine differences in miR-141-3p expression between AB tissues and normal oral tissues (NOMs). The potential target NCAM1 of miR-141-3p was predicted by bioinformatics analysis, which was validated through dual-luciferase assay. The mRNA and protein levels of NCAM1 were detected by real-time qPCR and Western blot, respectively. Furthermore, the expression and distribution of NCAM1 in AB were investigated through immunohistochemical staining, and immunohistochemical staining of E-cadherin was also performed. After overexpression of NCAM1, the migration of AM-1 cells was examined using wound-healing assay. Results Real-time qPCR results confirmed that miR-141-3p was significantly downregulated in AB tissues. According to bioinformatics analysis, NCAM1 was a target of miR-141-3p, which was confirmed by dual luciferase assay. We found that NCAM1 was significantly upregulated in AB tissues at the mRNA and protein levels. Furthermore, NCAM1 and E-cadherin were mainly expressed on the cell membrane of AB. Downregulation of E-cadherin was found in AB tissues. As shown in wound-healing assay results, NCAM1 overexpression significantly inhibited the invasiveness of AM-1 cells. Conclusions In this study, highly expressed NCAM1 was found in AB, and it suppressed the migration of AB cells and was regulated by miR-141-3p, suggesting its potential value as a therapeutic target for AB.
Exposure to negative stereotypes influences representations of monetary incentives in the nucleus accumbens

Abstract Contemporary society is saturated with negative representations of racial and ethnic minorities. Social science research finds that exposure to such negative stereotypes creates stress above and beyond pre-existing effects of income inequality and structural racism. Neuroscience studies in animals and humans show that life stress modulates brain responses to rewards. However, it is not known whether contending with negative representations of one’s social group spills overs to influence reward processing. We used functional magnetic resonance imaging to examine the effects of stigmatizing negative stereotypes on neural responding to the anticipation and consumption of monetary gains and losses in a Mexican American sample. Machine learning analyses indicated that incentive-related patterns of brain activity within the nucleus accumbens differed between Mexican Americans subjected to negative stereotypes and those who were not. This effect occurred for anticipating both gains and losses. Our work suggests that rhetoric stigmatizing Latinos and other minorities could alter how members of such groups process incentives in their environment. These findings contribute to our understanding of the linkage between stigmatizing experiences and motivated behavior, with implications for well-being and health.
Enzyme promiscuity and evolution in light of cellular metabolism

This Special Issue is composed of 10 reviews that delve into the intricacies behind enzyme promiscuity and evolution, an area that is of increasing interest in the biological research community. In particular, the reviews in this Special Issue explore enzyme promiscuity and evolution in the context of cellular metabolism, as discussed in this introductory Editorial. It is our hope that you enjoy these fascinating and informative reviews and we wish to thank the authors for their compelling contributions to The FEBS Journal. doi: 10.1111/febs.12650.
Enhancement of cariogenic virulence properties of dental plaque in asthmatics

Abstract Objective The aim of this study was to investigate the caries risk of asthmatics in relation to acidogenicity and the expression of caries-related genes in dental plaque. Methods A case-control study composed of 38 asthmatics (cases) and 22 controls with an age range from 6 to 60 years. Characteristics of asthma, use of medications, oral hygiene practices and dietary habits assessed by questionnaires and interviews. The dental plaque maturity evaluated using GC Tri Plaque ID Gel TM. The expression of brpA, gtfB, gbpB, ldh, luxS and spaP genes analyzed using real-time PCR. Results Asthmatics had a higher percentage of mature and acidogenic plaque than immature plaque. In contrast, immature plaque was more evident in controls. Acidogenic plaque commonly occurred in patients using 1 or a combination of two medications. High frequency in meals and sweets were found in asthmatics. Real-time PCR revealed that the expression of spaP, gtfB, gbpB, ldh, brpA and luxS were enhanced in asthmatics compared with the control group. Conclusion An increase in acidogenic and mature plaque is found in asthmatics. The expression of spaP, gtfB, gbpB, ldh, brpA and luxS in dental plaque are upregulated in asthmatics.
Applying the core microbiome to understand host-microbe systems.

1.The host-associated core microbiome was originally coined to refer to common groups of microbes or genes that were likely to be particularly important for host biological function. However, the term has evolved to encompass variable definitions across studies, often identifying key microbes with respect to their spatial distribution, temporal stability, or ecological influence, as well as their contribution to host function and fitness. 2.A major barrier to reaching a consensus over how to define the core microbiome and its relevance to biological, ecological and evolutionary theory is a lack of precise terminology and associated definitions, as well the persistent association of the core microbiome with host function. Common, temporal, and ecological core microbiomes can together generate insights into ecological processes that act independently of host function, whilst functional and host-adapted cores distinguish between facultative and near-obligate symbionts that differ in their effects on host fitness. 3.This commentary summarizes five broad definitions of the core microbiome that have been applied across the literature, highlighting their strengths and limitations for advancing our understanding of host-microbe systems, noting where they are likely to overlap, and discussing their potential relevance to host function and fitness. 4.No one definition of the core microbiome is likely to capture the range of key microbes across a host population. Applied together, they have the potential to reveal different layers of microbial organisation from which we can begin to understand the ecological and evolutionary processes that govern host-microbe interactions.
Chronic fatigue syndrome: progress and possibilities

Chronic fatigue syndrome (CFS) is a prevalent condition affecting about one in 100 patients attending primary care. There is no diagnostic test, validated biomarker, clear pathophysiology or curative treatment. The core symptom of fatigue affects both physical and cognitive activities, and features a prolonged post‐activity exacerbation triggered by tasks previously achieved without difficulty. Although several different diagnostic criteria are proposed, for clinical purposes only three elements are required: recognition of the typical fatigue; history and physical examination to exclude other medical or psychiatric conditions which may explain the symptoms; and a restricted set of laboratory investigations. Studies of the underlying pathophysiology clearly implicate a range of different acute infections as a trigger for onset in a significant minority of cases, but no other medical or psychological factor has been reproducibly implicated. There have been numerous small case–control studies seeking to identify the biological basis of the condition. These studies have largely resolved what the condition is not: ongoing infection, immunological disorder, endocrine disorder, primary sleep disorder, or simply attributable to a psychiatric condition. A growing body of evidence suggests CFS arises from functional (non‐structural) changes in the brain, but of uncertain character and location. Further functional neuroimaging studies are needed. There is clear evidence for a genetic contribution to CFS from family and twin studies, suggesting that a large scale genome‐wide association study is warranted. Despite the many unknowns in relation to CFS, there is significant room for improvement in provision of the diagnosis and supportive care. This may be facilitated via clinician education.
Use of oral paclitaxel for the treatment of bladder tumors in dogs

An oral paclitaxel formulation that overcomes the hypersensitivity reaction of paclitaxel has been evaluated for safety and efficacy in humans, but not in dogs. We present the first case report on the use of oral paclitaxel in dogs. In this study, oral paclitaxel was well-tolerated in four dogs with either transitional cell carcinoma or prostate cancer; adverse effects were limited to mild neutropenia. Each of the dogs had progressive disease at the end, but clinical responses, including changes in mass size and improvement of clinical symptoms, were confirmed in some of the animals following oral paclitaxel chemotherapy. Although this study is somewhat limited by a small sample size, it suggests that oral paclitaxel may be a chemotherapeutic option for malignant tumors in dogs.
Triage options to manage high‐risk human papillomavirus‐positive women: A population‐based cross‐sectional study from rural China

Improvement in managing HPV‐positive women is urgently needed. Based on a population‐based study which included 2112 women aged 49 to 69 from Shanxi, China, we aimed to evaluate the clinical performance of multiple triage strategies based on liquid‐based cytology (LBC), p16INK4a, viral load and partial genotyping, as a single or combined strategy for detecting cervical intraepithelial neoplasia grade 2/3 or higher (CIN2+/CIN3+) in women who tested positive by Hybrid Capture 2 (HC2). Among 452 HC2‐positive women, the test positivity of LBC (ASC‐US+), p16INK4a, HPV16/18 and HPV16/18/31/33/45 were 39.6%, 38.5%, 18.0% and 40.0%, respectively. Compared to LBC (ASC‐US+) triage, a single triage strategies using p16INK4a or extended genotyping (SureX HPV16/18/31/33/45) achieved comparable sensitivity (relative sensitivity: 1.08, 95% confidence interval [CI]: 0.93‐1.26 and 0.96, 95% CI: 0.76‐1.22) and specificity (relative specificity: 1.05, 95% CI: 0.96‐1.14 and 1.02, 95% CI: 0.92‐1.14) for CIN3+. Viral load triage using a ≥50 RLU/CO cut‐point also yielded similar results with LBC (ASC‐US+). Among combined triage strategies, HPV16/18 genotyping with reflex p16INK4a showed higher sensitivity and slightly lower specificity than LBC (ASC‐US+) for CIN3+ detection, however, the differences were not statistically significant. Of note, after a negative result by p16INK4a or LBC among HPV16/18 negative women, the posttest probability of CIN3+ was lower than 1%. Our study suggested that p16INK4a, extended genotyping and increased viral load cut‐point could be promising alternatives to cytology triage. Combined triage algorithms of HPV16/18 with reflex p16INK4a or cytology, if negative, are associated with the substantial low posttest risk sufficient to release women to next screening round.
Pixel2Mesh: 3D Mesh Model Generation via Image Guided Deformation

In this paper, we propose an end-to-end deep learning architecture that generates 3D triangular meshes from single color images. Restricted by the nature of prevalent deep learning techniques, the majority of previous works represent 3D shapes in volumes or point clouds. However, it is non-trivial to convert these representations to compact and ready-to-use mesh models. Unlike the existing methods, our network represents 3D shapes in meshes, which are essentially graphs and well suited for graph-based convolutional neural networks. Leveraging perceptual features extracted from an input image, our network produces the correct geometry by progressively deforming an ellipsoid. To make the whole deformation procedure stable, we adopt a coarse-to-fine strategy, and define various mesh/surface related losses to capture properties of various aspects, which benefits producing the visually appealing and physically accurate 3D geometry. In addition, our model by nature can be adapted to objects in specific domains, e.g., human faces, and be easily extended to learn per-vertex properties, e.g., color. Extensive experiments show that our method not only qualitatively produces the mesh model with better details, but also achieves the higher 3D shape estimation accuracy compared against the state-of-the-arts.
Speech Quality Assessment in Crowdsourcing: Inﬂuence of Environmental Noise

Micro-task crowdsourcing opens up new possibilities for investigating the inﬂuence of a variety of realistic environmental factors on the quality of transmitted speech as perceived by the user. This paper reports the inﬂuence of environmental noise on speech quality assessment ratings using crowdsourcing approach. In a two-phase ex-periment, subjects assessed the quality of speech stimuli from a standard dataset (SwissQual 501 speech database from the ITU-T Rec. P.863 competition) in diﬀerent environments. Phase A was conducted in the laboratory, in either silent or simulated environments with background noise. In phase B, the same group of participants completed the same task in diﬀerent crowdsourcing environments. The Mean Opinion Score (MOS) values, representing perceived overall quality, were calculated for each degradation condition and compared to the scores reported from the standard laboratory test. The highest correlation with standard laboratory test was achieved in the silent-laboratory environment ( r s = . 97). In the noisy (simulated) environments higher correlation was achieved when subjects were wearing in-ear headphones, and in crowdsourcing condition when they were performing their task in their living-room. It was also discovered that perceived loudness of the stimuli negatively correlates with the diﬀerence between MOS values obtained in test environmental conditions and the MOS values reported in the standard laboratory.
Acute hematogenous osteomyelitis in pediatric patients: epidemiology and risk factors of a poor outcome

Objective Acute hematogenous osteomyelitis (AHO) has declining incidence in developed countries. AHO can cause rapid destruction of bone that can lead to functional impairment or even death if misdiagnosed and not treated urgently. In this study, we aimed to identify the main factors that may lead to a poor outcome and to establish a profile of patients with AHO who might have a negative outcome. Methods We conducted a retrospective single-center study including 94 patients with AHO, over a 10-year interval. Complete medical history including age at diagnosis, sex, socioeconomic status, symptoms, entry portal, pathogenic agent, location of infection, radiological features, treatment, and outcome were recorded. Results Male predominance was observed, with boys from rural areas more prone to a poor outcome. This is likely because they are more exposed to trauma and do not have proper access to emergency medical care. Staphylococcus aureus was the most common etiologic agent, with 84 patients testing positive. Disease evolution was toward chronicity in patients diagnosed late. The most frequent complications were sepsis and pathological fractures. Conclusions In our study, patients with negative outcomes were characterized by young age, repeated negative cultures, delayed surgery, rural residence, and male sex.
Older Thai Peoples’ Perceptions and Experiences of Major Depression

BACKGROUND: Depressive disorders are common mental health problems and may be disabling among the general older population. Although older people have significant symptoms of depression, the symptoms are likely to be underreported. The condition often co-exist along with somatic ill and has often been unrecognized. The aim of the study was to explore and understand the perceptions and experiences of older Thai people diagnosed with major depressive disorder.METHODS: A qualitative inductive research design was used and latent content analysis was utilized. The data were collected through face-to-face, in-depth interviews. Fourteen older people diagnosed with major depressive disorder were selected for participant using purposive sampling. FINDINGS: Older Thai peoples’ perceptions and experiences of depression were abstracted into two themes. First theme was leading a life in detachment, which included three subthemes: living with meaninglessness, holding distress with one’s self, and feeling judged by surrounded people. The second theme was inconvenience of approaching mental health treatment, which included two subthemes: sensing an unapproachable health care service, and lacking knowledge about clinical depression.CONCLUSION: Older Thai peoples’ perceptions and experiences of major depression were affected with high level suspected existential loneliness that might even be worse in a collect oriented society as in the Thai context. Further, it seem hard to approach the mental health care. The central reason for this is interpreted as lack of mental health literacy, and in this case, specifically, knowledge on depression. Future studies should focus on relatives’ experiences of living with an older family member that suffered from major depression, and on the state of mental health literacy in the rural Thai population.