Miracle-dz/UniFAR-FTUs huggingface dataset:
インドネシア海大陸における降水の安定同位体の観察研究;インドネシア海大陸における降水の安定同位体の観察研究;Observational Research on Stable Isotopes in Precipitation over Indonesian Maritime Continent

The Indonesian Maritime Continent (IMC) is located in the tropics and consists of a number of islands and seas. This particular arrangement of land masses and seas produces unique weather and climate characteristics. Various hydrometeorology studies have been conducted exploring the variability of stable isotopes in precipitation over the IMC. Stable isotopes (δ18O and δD) in precipitation can be used to obtain information about atmospheric processes (e.g., precipitation, temperature and hydrological cycle). The Global Network of Isotopes in Precipitation, operated by the International Atomic Energy Agency, has been conducting worldwide monthly surveys of isotope levels in precipitation since 1961. To better understand the isotopic variability in the IMC, the Japan Agency for Marine-Earth Science and Technology began operating in the IMC region in 2001. There are three types of seasonal variation of stable isotopes in precipitation, depending on the level of precipitation amount and also stable isotopic value, namely, semiannual, anti-monsoonal and monsoonal. Negative correlations between the precipitation amount and stable isotope value (amount effect) were identified when using the monthly averages. The interannual variability of stable isotopes in precipitation was mainly because of El Niño Southern Oscillation activity, whereas intraseasonal variability was closely related to the Madden-Julian Oscillation. Stable isotope variability in short periods was found to be due to precipitation cloud types and post-condensation processes.
Epidemiological Study of Malaria Infection among Pregnant Women in Gombe, Gombe State, Nigeria

Malaria is one of the most devastating diseases plaguing mankind. The disease is endemic in tropical and sub-Saharan Africa of which Nigeria belongs. The Epidemiological study of malaria infection among pregnant women was carried out on 1,521 patients reporting for their first antenatal clinic in hospitals and clinics, in Gombe, Gombe State, Nigeria. Giemsa stained thick and thin films for malaria parasite test was carried out on the women, alongside obtaining information on their socio-demographic characteristics. Most of our participant were in the age group 21-30 years (56.34%), while most of them had their secondary education (49.85%) and were housewives 99.41%. The prevalence of malaria was 8.48%, with the 21-30 year old age group having the highest prevalence of malaria (56.34%). The highest prevalence of malaria was among those in their second trimester (11.48%), while those with more than seven children had the highest prevalence of malaria (25.00%). The highest prevalence of malaria was seen among those with non-formal education (11.30%), housewives (8.44%) and the single pregnant women (22.22%). The prevalence of malaria was statistically significant with age group and occupation. We advise that measures encouraging personal and environmental hygiene, use of prophylactic drugs and sleeping under treated mosquito nets should be encouraged to reduce the prevalence of malaria among the pregnant women.
Influence of the age on hematological parameters of sindi cattle (Bos indicus) in Paraíba Backwoods

Delfino L.J.B. , de Souza B.B. , Silva W.W. , Ferreira A.F. & Soares C.E. A. Influence of the age on hematological parameters of Sindi cattle ( Bos indicus) in Paraiba backwoods. (Influencia da idade nos parâmetros hemato - logicos do gado Sindi (Bos indicus) no sertao paraibano. ) Revista Brasileira de Me- dicina Veterinaria, 36(3):266-270, 2014. Departamento de Medicina Veterinaria, Universidade Federal de Campina Grande, Campus de Patos, Av. Universitaria, s/n, Santa Cecilia, Patos, PB 58708-110, Brasil. Email: zulu_vet@hotmail.com The aim this work was to establish reference values of the hemogram of Sindi cattle raised in Paraiba backwood and evaluate the influence of same age, on blood samples we collected from 60 clinically healthy animals, being 30 females and 30 males, with the following age groups: Group I: 6 - 24 months, Group II: 24 - 48 months and Group III: up to 48 months. The experiment was conducted at the Center for Research and Development for the Semiarid Tro- pics (NUPEARIDO) and the Veterinary Clinical Pathology Laboratory of the Health Center and Rural Technology (CSTR), Universidade Federal de Campi- na Grande (UFCG), Campus de Patos-PB. Blood samples were placed in tubes containing EDTA (tetracetico-ethylenediamine-di-sodium) as an anticoagulant were performed the following tests: counting the number of red blood cells, packed cell volume (PCV), Hemoglobin (Hb) content, calculations of absolu- te Erythrocyte count (RBC), Mean corpuscular volume (MCV) and Mean cor- puscular hemoglobin concentration (CHGH). Held global count and differen- tial leukocyte such as segmented neutrophils, eosinophils, lymphocytes and monocytes. Reference values for erythrocyte count (RBC), hematocrit (PCV), hemoglobin (Hb), MCV and CHGH were, respectively, (6375 to 13,400 X10 6 / MM 3 ), (32 - 50 %), (9 - 15 G/DL) (37 - 60 µ 3), (23 to 33 µµG). And for the WBC were obtained the following results: WBC (5270 to 17,170 UL), segmented neu- trophils (from 1360 to 5780 UL) Eosinophils (240 to 2525 UL), lymphocytes (2330 to 11,470 UL), monocytes (72 - 116 UL). With the results showed differences in hematological values were important to establish reference values for breed.
Structure and functional divergence of PIP peptide family revealed by functional studies on PIP1 and PIP2 in Arabidopsis thaliana

PAMP-induced secreted peptide (PIP), one of the small post-translationally modified peptides (PTMPs), plays a crucial role in plant development and stress tolerance. However, little is known about functional divergence among this peptide family. Here, we studied the evolution of the PIP family in 23 plant species (10 monocotyledons and 13 dicotyledons from 7 families) and their functional divergence in Arabidopsis. A total of 128 putative PIP precursors were identified and classified into two subfamilies through phylogenetic analysis. Functional studies on AtPIP1 which represents Clade I family and AtPIP2 which represents Clade II family have shown that AtPIP2 displayed stronger immunity induction activity but weaker root growth inhibition than AtPIP1 in Arabidopsis. Transcriptome analysis of Arabidopsis seedlings treated with AtPIP1 and AtPIP2 showed that differential genes for both polypeptides were significantly enriched in similar plant defense pathways. However, Co-expression and Protein-protein interaction (PPI) analysis showed that the functions of AtprePIP2 co-expressed genes were more enriched in plant defense pathways than AtprePIP1. Molecular docking results show that AtPIP1 binds to RLK7 receptor with a more stable free energy and less binding area than AtPIP2, while hydrogen bond transfer occurs at the SGP motif position. The above results suggest that the PIP family have undergone functional divergence during evolution. Collectively, this work illustrates the relationship between PIP structure and function using Arabidopsis PIP as an example, and provides new insights into the current understanding between growth inhibition and immune responses which may be correlated but not fully coupled.
Analysis Physical Condition of The Position Women’s Basketball Players Perennial Foundation Of Perbaspa Kediri District

This study aims to determine: (1) physical condition of arm muscle strength, (2) speed, (3) agility, (4) leg muscle power, (5) endurance, (6) physical condition of women's basketball players Perbaspa Perbaspa Foundation Kediri Regency based on player position. This type of research is quantitative descriptive research with data collection techniques using survey methods with test and measurement techniques. The population in this study were all female basketball players at the Perbaspa Abadi Foundation, Kediri Regency, consisting of 15 players. The sampling technique in this study is total sampling. The test instruments used were the push up test, 30 meter sprint, dogging run, vertical jump and multistage fitness test. The results showed that the physical condition of women's basketball players at the Abadi Perbaspa Foundation, Kediri Regency in the components of arm muscle strength, 12 players (80%) were in the poor category, the speed of 5 players (33%) was in the medium category, the agility of 15 players (100%) was in the very category. good, leg muscle power of 11 players (73%) is in the poor category, endurance of 13 players (87%) is in the very poor category. The results of the physical condition based on the player's position show that the dominant physical condition of the point guard position (PG1) is speed and agility, the shooting guard position (SG2) speed and agility, small forward agility (SF3), power forward position (PF4) arm muscle strength, speed and agility, middle position (C5) speed and agility. Physical condition is one aspect that cannot be underestimated, because basketball players have positions and tasks where each task requires different components of physical condition, so coaches need to know what physical components are needed to improve performance.
Development of a Nomogram Based on Diffusion-Weighted Imaging and Clinical Information to Predict Delayed Encephalopathy after Acute Carbon Monoxide Poisoning.

BACKGROUND Delayed encephalopathy after acute carbon monoxide poisoning (DEACMP) is a severe complication that can arise from acute carbon monoxide poisoning (ACOP). This study aims to identify the independent risk factors associated with DEACMP and to develop a nomogram to predict the probability of developing DEACMP. METHODS The data of patients diagnosed with ACOP between September 2015 and June 2021 were analyzed retrospectively. The patients were divided into the two groups: the DEACMP group and the non-DEACMP group. Univariate analysis and multivariate logistic regression analysis were conducted to identify the independent risk factors for DEACMP. Subsequently, a nomogram was constructed to predict the probability of DEACMP. RESULTS The study included 122 patients, out of whom 30 (24.6%) developed DEACMP. The multivariate logistic regression analysis revealed that acute high-signal lesions on diffusion-weighted imaging (DWI), duration of carbon monoxide (CO) exposure, and Glasgow Coma Scale (GCS) score were independent risk factors for DEACMP (Odds Ratio = 6.230, 1.323, 0.714, p < 0.05). Based on these indicators, a predictive nomogram was constructed. CONCLUSIONS This study constructed a nomogram for predicting DEACMP using high-signal lesions on DWI and clinical indicators. The nomogram may serve as a dependable tool to differentiate high-risk patients and enable the provision of personalized treatment to lower the incidence of DEACMP.
Idiosyncratic DILI: Immunology in Cases with Evidence Based on RUCAM

Idiosyncratic drug induced liver injury (iDILI) is a multifaceted and fairly well described liver disease, but there is yet some uncertainty on the role of immune systems triggering the liver injury and speculation on the cascade of immune events. Many conclusions were so far based on narratives or cases of iDILI, which did not receive the benefit of a robust causality assessment like by the Roussel Uclaf Causality Assessment Method (RUCAM). This analysis aims to clarify the cascade of immune events that lead to the liver injury by conventional drugs. For this approach, the search focused on iDILI cases with verified diagnosis by RUCAM. Most promising were parameters obtained from the blood as mirror of what happened in the liver during the injurious processes.The focus of this present analysis is on patients with RUCAM based iDILI and concomitant immune-related parameters in the blood. As an example, compelling evidence for a role of immune systems in iDILI was found for circulating mediators in the blood secreted by liver immune cells in patients under a therapy for tuberculosis, detected were also serum anti-cytochrome P450 (CYP) antibodies in patients after anesthesia with sevoflurane or desflurane and thereby reflecting their metabolism by the CYP 2E1 isoform, the occurrence of serum of autoantibodies in patients with drug induced autoimmune hepatitis (DIAIH) due to many drugs, and the role of blood and liver monocytes, which provide direct evidence for the activation of the hepatic innate immune system to the adapted immune system. In essence, patients with RUCAM based iDILI show various immunology features in the blood compatible with the role of the hepatic immune systems in patients with suspected iDILI caused by some but not all drugs.
Strategic Intervention for Selected Deviant English Phrases at a rural University

Professionalism in English phrases is an indispensable tool for the enhancement of fluency and accuracy in communication. However, English second language learners face redundancy challenges apropos an effective use of phrases. The research investigated strategic intervention for selected deviant English phrases at the University of Venda. A quantitative approach was adopted because data could be analysed mathematically and statistically. Using probability sampling, 35 Level Three English students registered in the 2022 academic year at this university were selected to participate in this research. Further, a convenience technique was employed to select the respondents who were readily approachable and had been studying English for more than twelve years. A pre-test study was conducted on the respondents who were not part of the target group to plan and modify the main research. After a treatment process was followed, the research revealed that respondents were incompetent in the use of English phrases. Nonetheless, post-test results established that respondents performed preternaturally after the utilisation of the ‘language shadowing methods’. Frequent practice in the use of this technique, therefore, cannot be ignored if one wishes to improve not only the art of public oration but also the image of the person's academic literacy.
TIL-Derived CAR T Cells Improve Immune Cell Infiltration and Survival in the Treatment of CD19-Humanized Mouse Colorectal Cancer

Simple Summary Lack of a tumor-specific antigen as the target and an inhospitable tumor environment limit the clinical application of Chimeric antigen receptor-engineered T cells (CAR Ts) in solid tumors, compared with its unprecedented results in treating hematological cancers, while tumor-infiltrating T lymphocytes (TIL) exhibit diverse T cell receptor clonality and superior tumor-homing abilities. In our study, we took advantage of the dual advantages of TIL-T and CAR T and constructed TIL CAR-T cells capable of MHC molecules and co-stimulatory signal-independent activation with tumor-specific broad-spectrum TCR expression. We innovatively constructed a humanized mouse colorectal cancer model, which provides an important platform for subsequent evaluation of human CD19-target CAR T cells. Meanwhile, TIL CAR-T cells have better anti-tumor efficacy than conventional CAR T, characterized by a better ability to enhance tumor invasion, relieve T cell exhaustion, and promote immune memory. Abstract Chimeric antigen receptor-engineered T cells (CAR Ts) targeting CD19 have shown unprecedented prognosis in treating hematological cancers. However, the lack of a tumor-specific antigen as the target and an inhospitable tumor environment limit the clinical application of CAR T in solid tumors. Tumor-infiltrating T lymphocytes (TIL) exhibit diverse T cell receptor clonality and superior tumor-homing abilities. Therefore, in our study, human CD19-target TIL CAR-Ts armed with CD3ζ and 4-1BB signaling domains were constructed. Mouse colorectal cancer CT26 cells expressing human CD19 (hCD19+-CT26) were developed to assess the anti-tumor activity of TIL CAR-T cells, both in vitro and in vivo. Compared with splenic CAR T adoptive transfer, TIL CAR-T administration showed superior tumor suppression ability in hCD19+-CT26 tumor-bearing mice. Furthermore, more T cells were found at the tumor site and had lower exhaustion-related inhibitory receptor (T cell immunoglobulin and mucin domain-containing protein 3, Tim3) expression and higher immune memory molecule (CD62L) expression. Overall, we provided an artificial tumor-specific antigen in solid tumors and demonstrated that combined CAR-expressing TIL-Ts (TIL CAR-Ts) exhibited strong anti-tumor activity, with improved T cell infiltration and immune memory. Our humanized tumor antigen presented platform of mice suggests that TIL CAR-T-based adoptive therapy could be a promising strategy for solid cancer treatment.
Needs Analysis: Developing an Innovative Instructional Module to Teach Osmosis and Diffusion Concepts

In education, learning and teaching activities play a vital role in presenting permanent and meaningful learning to Science students, including those studying Biology. The perception of Biology as a challenging subject stems from students' difficulty visualizing molecular processes and their lack of skills in solving higher-order thinking problems. Bridging this gap in Biology instruction becomes imperative to enhance students' understanding. Thus, the objective of this study is to perform a needs analysis in order to assess the necessity for developing an innovative instructional module to teach osmosis and diffusion concepts for the Form Four Biology curriculum. This study applied the Design and Development Research (DDR), using the ADDIE model (Analyze, Design, Develop, Implement and Evaluate). A research question was formulated for this study; how crucial is the development of an innovative teaching and learning module in teaching osmosis and diffusion concepts, in the view of experts? To seek the answer, semi-structured interviews were conducted involving three field experts. The data acquired from the interviews were analyzed using thematic analysis, facilitated by the use of Atlas.ti software. The key findings revealed four major themes that emerged from the needs analysis: (1) The importance of learning osmosis and diffusion, (2) Problems in Biology teaching and learning, (3) Teaching strategies, and (4) Desired improvements. Based on these themes, it appears that an alternative teaching module is needed to simplify the process of teaching and learning the concepts of osmosis and diffusion for both students and teachers. This study’s implication can be observed in terms of practice in the school context, where it provides an alternative tool for teaching and learning Biology.
Melody for the Mind: Enhancing Mood, Motivation, Concentration, and Learning through Music Listening in the Classroom

Listening to music has been shown to have positive impacts on mood and task performance, but there is little knowledge on such effects in school environments. This mixed-method study aimed to investigate the effects of self-selected music on students’ mood, motivation, concentration, and learning success in a real-life school context. Forty-eight secondary school students (age range: 15–19) completed the study, and both quantitative and qualitative data were collected. The study consisted of two phases: one week of regular lessons without music and a subsequent week in which students listened to self-selected music before each lesson. The results showed that listening to music had strong positive effects on mood, motivation, and concentration, and moderate effects on learning. Qualitative analysis of open-ended questions revealed that the beneficial effects were mostly perceived to be due to creating positive and energizing emotions, increasing attention, and providing routine and rest between lessons. The findings suggest that listening to self-selected music could be an effective and low-cost strategy for enhancing students’ emotional state, motivation, and concentration in a school context.
Analysis of prognostic factors in patients diagnosed with bladder cancer complicated by hemorrhage treated by drug-eluting bead embolization

Background Transcatheter bladder arterial chemoembolization (TACE) is an alternative treatment used to control bladder cancer (BC) with bleeding, especially in older adult patients with comorbidities. This retrospective observational study evaluated the effect and prognostic factors of transcatheter drug-eluting bead (DEB) embolization in patients with advanced BC. Methods We assessed 39 patients diagnosed with BC with hemorrhage who were either inoperable or unwilling to undergo surgery at our hospital between January 2018 and October 2022. All patients underwent TACE by DEB loaded with epirubicin and imaging scans after 2 months to evaluate the curative effect according to the modified Response Evaluation Criteria in Solid Tumors (mRECIST) standard to determine treatment. Re-examination and follow-up were performed every 3–6 months to observe hematuria recurrence and the curative effect. Results A total of 95 interventional treatments were performed in 39 patients, and all participants achieved complete hemostasis within 5 days after the first intervention. Computed tomography or magnetic resonance imaging showed that the total effective rate [complete response (CR) + partial response (PR)] was 64.1%, and the disease benefit rate (CR +PR + stable disease) was 79.5%. A total of 30 patients (76.9%) had no hematuria recurrence. Logistic regression analysis indicated that the type of blood supply in BC may relate to whether the patients benefited from the intervention. Hematuria recurrence was significantly associated with the total number of tumors and the type of blood supply (P<0.05). Conclusions Superselective embolization of bladder arteries with DEB can be used to treat BC with hemorrhage. However, hypovascular tumor blood supply may result in poor postoperative efficacy and hematuria recurrence. Additionally, multiple bladder tumors may be a risk factor for hematuria recurrence.
Exceptionally Fast Temperature-Responsive, Mechanically Strong and Extensible Monolithic Non-Porous Hydrogels: Poly(N-isopropylacrylamide) Intercalated with Hydroxypropyl Methylcellulose

Exceptionally fast temperature-responsive, mechanically strong, tough and extensible monolithic non-porous hydrogels were synthesized. They are based on divinyl-crosslinked poly(N-isopropyl-acrylamide) (PNIPAm) intercalated by hydroxypropyl methylcellulose (HPMC). HPMC was largely extracted after polymerization, thus yielding a ‘template-modified’ PNIPAm network intercalated with a modest residue of HPMC. High contents of divinyl crosslinker and of HPMC caused a varying degree of micro-phase-separation in some products, but without detriment to mechanical or tensile properties. After extraction of non-fixed HPMC, the micro-phase-separated products combine superior mechanical properties with ultra-fast T-response (in 30 s). Their PNIPAm network was highly regular and extensible (intercalation effect), toughened by hydrogen bonds to HPMC, and interpenetrated by a network of nano-channels (left behind by extracted HPMC), which ensured the water transport rates needed for ultra-fast deswelling. Moreover, the T-response rate could be widely tuned by the degree of heterogeneity during synthesis. The fastest-responsive among our hydrogels could be of practical interest as soft actuators with very good mechanical properties (soft robotics), while the slower ones offer applications in drug delivery systems (as tested on the example of Theophylline), or in related biomedical engineering applications.