Miracle-dz/UniFAR-FTUs huggingface dataset:
OTT_A_245813 2997..3011

Liuliu Guan Qingqing Zou Qian Liu Yiguang Lin 3,4 Size Chen 1Department of Oncology, The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, People’s Republic of China; 2Guangdong Provincial Engineering Research Center for Esophageal Cancer Precise Therapy, Guangzhou, The First Affiliated Hospital of Guangdong Pharmaceutical University, People’s Republic of China; 3Central Laboratory, The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, People’s Republic of China; 4School of Life Sciences, University of Technology Sydney, Sydney, NSW, Australia Purpose: Currently, the paucity of classical effective pharmacological drugs to treat esophageal squamous cell carcinoma (ESCC) is a major problem. The c-Myc (MYC) protein is a promising target as it is overexpressed in ESCC. MYC is a sensitive client protein of the heat shock protein 90 (HSP90) and, therefore, targeting the HSP90-MYC axis by inhibition of HSP90 is a potential therapeutic strategy for ESCC. Here, we evaluated the clinical application value of the HSP90 inhibitor (Ganetespib, STA-9090) as an anti-cancer agent for MYC-positive ESCC. Materials and Methods: We first analyzed ESCC tissue microarrays and clinical tissue samples to determine MYC expression. The relationship between MYC and HSP90 was analyzed by co-immunoprecipitation assays and immunofluorescence. In in vitro cell models, cell growth was analyzed using the CCK-8 kit, and MYC protein expression was analyzed by Western blot. The in vivo antitumor activity of STA-9090 was assessed in two xenograft animal models. Results: We demonstrated that MYC-overexpressing ESCC cells were highly sensitive to STA-9090 treatment through suppressing ESCC cell proliferation, cell cycle progression and survival. Moreover, STA-9090 treatment decreased MYC expression, reducing the half-life of the MYC protein. We further established two xenograft mouse models using ESCC cells and clinical ESCC samples to validate the effectiveness of STA-9090 in vivo. In both xenograft models, STA-9090 substantially inhibited the growth of MYC-positive ESCC tumors in vivo. In contrast, STA-9090 treatment demonstrated no beneficial effects in mice with low-MYC expressing ESCC tumors. Conclusion: In conclusion, our data support that the HSP90 inhibitor, STA-9090, suppresses the expression of the MYC protein and interferes with HSP90-MYC protein–protein interaction. This, in turn, leads to inhibition of ESCC cell proliferation and promotion of apoptosis in ESCC cells in vitro and reduction of ESCC tumors in vivo. We propose, based on our findings, that STA-9090 is a potential novel therapeutic target for MYC-positive ESCC.
The potential use of extended criteria donors and eligible recipients in liver transplantation for unresectable colorectal liver metastases in Central Sweden.

Background Unresectable colorectal liver metastases (CRLM) is a condition with poor prognosis. A recent treatment alternative improving survival in patients with unresectable CRLM, has emerged with the introduction of liver transplantation (LT), yet not uncontroversial with the current organ shortage. This study aimed to retrospectively investigate the potential of declined donors with acceptable risk as liver graft donors and patients with unresectable CRLM as potential recipients. Methods All declined donors in central Sweden and all patients with CRLM discussed at multidisciplinary team conference at Karolinska University Hospital, January 2013-October 2018, were identified. Donors were classified according to the European Committee Guide to the quality and safety of organs for transplantation and potential recipients were evaluated by selection criteria, based on studies on the Norwegian Secondary Cancer study database. Results Out of 1,462 evaluated potential donors, 62 (2.7 pmp) donors were identified, corresponding to 6-18% of the utilized donor pool. Out of 1,008 included patients with CRLM, 25 (2.1 pmp) potential recipients were recognized. Eligibility for LT and left-sided colon cancer were favorable prognostic factors. Conclusions Today's donor pool could increase with the use of extended criteria donors, which is sufficient and display an acceptable risk-benefit ratio for patients with unresectable CRLM. With current selection criteria a small subset of patients with unresectable CRLM are eligible recipients. This subset of patients has a better survival compared to patients ineligible for LT.
Identification and comparison of three carp fishes based on mitochondrial 16S rRNA gene

Identification of Labeo rohita, L. bata and L. gonius is sometimes problematic when usual morphological features are lost and it is difficult to differentiate them with traditional morphological features at their diverse developmental stages. PCR-sequencing provides an authentic alternative means of identification of individuals at species level. Three local carp fishes were collected and 16S rRNA genes were sequenced by sanger sequencing method after PCR amplification using universal primers. Obtained sequences were found accurate with blast search result which showed maximum range of similarity with the existing respective gene fragments present in GenBank database. Sequences were compared and multiple sequence alignment has revealed some polymorphic sites which can be used to differentiate these three species from one another. This study may provide valuable understanding to study their population in future.
The Moderating Role of Operational Control in the Relationship between Entrepreneurial Activity and Innovation Performance in Car Industry of Thailand

The main focus of the current study is to investigate the moderating role of operational control in the relationship between entrepreneurial activity and innovation performance. The present research aims to observe the association between antecedents and operations control mechanism, innovation performance, and corporate entrepreneurship. Innovation performance is defined as the extent of a firms’ level of attained success in achieving technologically innovative and product market goals. A theoretical base of current study states that there is no contradiction among the operations control mechanism and corporate entrepreneurship interests. The SEM-PLS is employed as a statistical tool to analyze the data. The current data revealed that strong positive influence of risk control as moderator was found on the innovation performance and organizational boundaries relationship, and a strong negative effect on the organizations’ innovation performance and time availability relationship. Thus, the possible influence caused by operation control variables must also be acknowledged. The recent research suggested that innovation should be taken and treated by managers as a responsive process for a disciplined and structured supervision. In addition, undertaking innovative initiatives require managers to deliberately construct and understand the means of generating desirable innovation outcomes.
Experimental Investigation of the Fatigue Behavior of Basalt Fiber Reinforced Polymer Grid-Concrete Interface

Fatigue behavior is an important factor for mechanical analysis of concrete members reinforced by basalt fiber reinforced polymer (BFRP) grid and polymer cement mortar (PCM) and plays a critical role in ensuring the safety of reinforced concrete bridges and other structures. In this study, on the basis of the static loading test results of concrete specimens reinforced by BFRP grid and PCM, a series of fatigue tests with different loading levels were conducted on interfaces between BFRP grid and concrete to investigate the fatigue behavior of BFRP grid-concrete interfaces. The test results indicate that with high loading level, the fatigue failure mode of interface is interfacial peeling failure while it transforms to the fatigue fracture of the BFRP grid under low loading level. The fatigue life (S-N) curves of BFRP grid-concrete interface are obtained and fitted in stages according to different failure modes, and the critical point of the two failure modes is pointed out. The relative slip evolution of interface during fatigue is further revealed in different stages with two failure modes, and the law of interface strain is studied with the increase of fatigue times. The relation of effective bonding length of interface and fatigue times is also described.
DIVERSITY OF PHYLLOPLANE MYCOBIOTA OF TWO MANGROVE SPECIES CERIOPS TAGAL AND AEGICERAS CORNICULATUM UNDER NATURAL AND GREENHOUSE CONDITIONS

The investigation focuses on composition and diversity of phylloplane mycobiota of two mangrove species Ceriops tagal (Perr.) C.B. Rob. and Aegiceras corniculatum (L.) Blanco from Pakistan coast and greenhouse grown plants. Altogether twenty-nine fungal species of seventeen genera were recorded from phylloplane of the two mangrove species. Phylloplane mycobiota from greenhouse plants showed lesser number of species. Greater number of species and genera were recorded for Ceriops tagal compared to Aegiceras corniculatum. In general, the phylloplane mycobiota was dominated by the genera Aspergillus, Fusarium and Cladosporium. The genus Aspergillus was represented by seven species of which Aspergillus niger, A. terreus and A. flavus were most abundant measured by CFUs/cm on the phylloplane. Species diversity and its components for the fungal communities were estimated. It was found that the general diversity (H') was slightly but consistently higher for Ceriops tagal compared to Aegiceras corniculatum. However, equitability (J') was slightly higher for Aegiceras corniculatum. Regarding sites, equitability was slightly higher for Sonmiani and Keti Bunder but lower for plants grown in the greenhouse. The mycobiota assemblages, in general, were dominated by the genus Aspergillus. High qualitative similarities of phylloplane micro fungal assemblages were demonstrated between mangrove species and between sites. Generally, the diversity was lower for the phylloplane fungal assemblages of the greenhouse. The relationship between air-spores and the phylloplane fungal assemblages showed a great deal of correspondence. Key-words: Fungal diversity, phylloplane microflora, mangrove species, Aegiceras corniculatum, Ceriops tagal
Treatment of Post-Stroke Depression in Young Stroke Survivors

Background: Stroke or cerebrovascular accident (CVA) is one of the leading causes of death and long-term disability in the United States. Stroke is most commonly seen in the elderly population. However, studies show that the incidence of this devastating condition is increasing among the younger generation. Potential causes of increased incidences of young people stroke include better diagnostic tests with neuroimaging, increased use of illicit drugs, and increased occurrences of risk factors. Stroke patients are not only affected by long term physical and cognitive disabilities, but also by psychological challenges such as Post-Stroke Depression (PSD). Depression is the most common neuropsychiatric complication of a stroke. However, PSD is often overlooked, and it is an aspect that receives the least attention from clinicians. As a result, there is an increased rate of morbidity and mortality among young stroke victims with depressive symptoms compared to those of the same age without PSD. The purpose of this article is to explore existing knowledge of current guidelines used to treat PSD, specifically in young stroke patients. This is all in an effort to better assist clinicians in treating PSD and in turn improve young patients’ quality of life. Method: An electronic database search was done through MedLine, PubMed, Cumulative Index to Nursing and Allied Health Literature (CINAHL), and Google Scholar. Key words such as “young stroke,” “depression,” and “treatment” were used to gather relevant articles. Results: Pharmacological therapy with SSRIs and TCAs has been highly successful for PSD in general population. However, no studies were found that specifically address treatment options for young stroke patients. Conclusion: Clinicians play a crucial role in helping young stroke survivors to recover and possibly resume their previous lives. Therefore, further research is warranted to evaluate the effects of current PSD treatment options that specifically target young stroke population.
EFFECT OF LINSEED OIL BEADS ADDITION WITH VITAMIN E ON PERFORMANCE, BLOOD METABOLITES AND MILK YIELD OF LACTATING GOATS

This study aimed to determine the effects of addition of capsulated linseed oil (beads) alone or in combination with vitamin E (α-tocophyrol acetate) as feed additives on animal performance, blood plasma and milk fatty acid (FA) profiles during lactation period. Twenty four Damascus pregnant doses of about 44.5 ± 1.2 kg live body weight were randomly allotted to 3 groups of 8 doses each and assigned to receive one of three experimental diets: control group: where goats were received berseem hay and concentrate feed mixture (50:50) without any additives, (CON), LO group: goats were offered control diet plus 2.5 gm beads/head/day and LO+VE group: goats were offered control diet plus 2.5 gm beads plus 600 IU VE/head/day. The experiment lasted for about 135 days (from mid pregnancy and lasted 60 days post-partum). Results showed that LO beads inclusion strongly increased milk yield, fat (P<0.01), protein, lactose, total solids yield (P<0.05) and milk fat % (P<0.05) compared with control. Blood plasma γ-linolenic acid was positively affected by beads while C20:2ω6 was increased (P<0.05) by beads plus VE. Moreover, beads inclusion reduced lauric (C12:0), myristic (C14:0) and palmitic (C16:0) (P<0.05) acids while increased contents of monounsaturated fatty acids (MUFA) as oleic (C18:1ω9) and polyunsaturated fatty acids (PUFA) as γ-linoleic (C18:3ω3) (P<0.01) and C18:4ω3 (PP<0.05) compared with control milk. As a consequence reduction of the proportions of total SFA (P<0.01), total omega-6 FAs (P<0.05) and omega-6: omega-3 ratio and enhanced the proportions of unsaturated FAs (UFA) and omega-3 FAs (P<0.01) resulted in health quality of goat’s milk was improved. In addition, some of blood plasma metabolites were improved with beads where plasma createnine, cholesterol (PP<0.05) and lipase activity (P<0.01) were decreased compared with control animals. Plasma urea (P<0.05), triglycerides (TG) (P<0.01), low density lipoprotein (LDL) (P<0.05), high density lipoprotein (HDL) (P<0.01) and total antioxidant capacity (TAC) (P<0.05) were increased while lipase activity was decreased with VE addition. The inclusion of VE combined with LO beads didn’t result in benefits in goat’s products. Further in vivo studies should be undertaken to explore suitable level of vitamin E in association with protected form of useful and healthy fatty acids.
Special issue in honour of Prof. Reto J. Strasser - Monitoring seasonal damage of photosynthetic apparatus in mature street trees exposed to road-side salinity caused by heavy traffic

De-icing salts are harmful for road-side greenery. The aim of our study was to examine photosystem II performance in mature trees growing along a road of heavy traffic in relation to shoot and soil salinity caused by de-icing salts. Leaves from each three specimens of Aesculus hippocastanum, Tilia cordata, and Betula pendula growing along the same road, nine leaves from a road-side part (RS) and nine from an opposite part (OS) of each tree crown, were sampled in June, July, and September, 2017 and 2018. The PSII performance in RS and OS leaves was compared using chlorophyll a fluorescence (ChF) technique. Since the beginning of the both growing seasons, several parameters of ChF were different in OS and RS leaves, especially maximum quantum yield of primary photochemistry and efficiency of electron movement beyond plastoquinone QA- markedly decreased in RS leaves. However, PSII performance was not directly bound to shoot/soil salinity.
Determinants and convergence of income diversification in Ghanaian banks

The study explores the determinants of income diversification, as well as, test for the existence of beta-convergence and sigma-convergence among Ghanaian banks. The study utilizes a dataset of 32 banks covering the periods 2000 to 2017. The panel corrected standard error ordinary least squares, fixed effects and system generalized methods of moments have been used. Both betaconvergence and sigma-convergence exist among Ghanaian banks; suggesting the presence of the catch-up effect and similarity of strategy over time. The risk profile and risk portfolio of banks affect their diversification strategy. Banks that are faced with high insolvency risk and liquidity risk tend to diversify while banks that are faced with low credit risk tend to diversify. Stable banks tend to adopt a diversification strategy even when they are exposed to credit risk. Network embeddedness drives diversification strategy. The implications of the study for practice, policy, and future research have been discussed.
Crowding-Out At The Top: The Heterogeneous Impact of R&D Subsidies on Firm Investment

This paper studies the impact of public R&D subsidies on investment decisions of recipient firms. I use quantile regression methods to characterize the effect of the subsidy at various points of firms’ R&D investment distribution. The identification strategy exploits a discontinuity in the probability of receiving the subsidy which results from program specific eligibility requirements. I find that the impact of public subsidies on firm investment varies significantly according to the amount of firm R&D investment. Subsidies to large R&D investors crowd-out their private R&D investment, whereas subsidies to small R&D investors add to their private investment. The magnitude of this crowding-out effect is both economically relevant and statistically significant. JEL classification: G32, H25, 031
Periodontal Disease Indices and Colorectal Cancer Risk in Greek Adults: A Case-Control Study

Introduction: The previous researches have recorded positive associations between periodontal disease (PD) and risk of cancer at various locations. The aim of the present case–control study was to investigate the possible associations between PD indices and the risk of colorectal cancer (CRC) development in a sample of Greek outpatients referred to a medical and dental private practice. Materials and Methods: A total of 342 individuals were interviewed and underwent an oral clinical examination, and 85 of them were suffered from CRC at various anatomic locations. The evaluation of the possible associations between CRC and PD indices was performed using a regression analysis model. Results: Clinical attachment loss (CAL) (P = 0.042, odds ratio [OR] = 1.78, 95% confidence interval [CI] = 1.02–3.11) was significantly associated with the risk of developing CRC. CRC family history (P = 0.002, OR = 2.33, 95% CI = 1.35–4.03) and smoking (P = 0.019, OR = 1.96, 95% CI = 1.12–3.45) were also significantly associated with the mentioned risk, whereas smoking was found to be nota confounder regarding the estimated association between moderate/severe CAL with the risk of developing CRC. Conclusion: CAL as an index for PD severity was statistically significantly associated with the risk of developing CRC.
ARBUSCULAR MYCORRHIZAL SYMBIOSIS ALLEVIATES DROUGHT STRESS IMPOSED ON WHEAT PLANTS (TRITICUM AESTIVUM L.)

Absract. The aim of this study was to determine the contribution of native arbuscular mycorrhizal fungi (AMF) inoculation to growth, pigmentation and grain yield of wheat plants ( Triticum aestivum L.) grown under different levels of water deficiency [D0, 100% Field Capacity (FC); D1, 75% FC; D2, 50% FC and D3, 25% FC]. The results suggested that AMF inoculation has a beneficial effect on plant drought tolerance and effectively improved biomass and crop productivity of wheat plants grown under drought. Mycorrhizal symbiosis alleviates the inhibitory effect of drought stress via improving water status and chlorophyll biosynthesis of wheat plants. Mycorrhizal colonization increased gradually and was higher at the maturity stage under a low level of drought (D1). The mycorrhizal wheat plants had higher shoot phosphorous than non-mycorrhizal plants at all samplings regardless of levels of drought stress. In general, with all treatments, the content of photosynthetic pigment fractions was inhibited as the level of drought increased in the soil pot experiment. However, the photosynthetic pigment contents of mycorrhizal wheat plant leaves were significantly (p<0.05) greater than those of non-mycorrhizal ones. The study/ concluded that the native mycorrhizae alleviate the drought stress by enhancement of the process of phosphorus uptake, pigment biosynthesis and accumulation of plant metabolites and may be used as a biofertilizer.
Multilingual Transformer-Based Personality Traits Estimation

Intelligent agents have the potential to understand personality traits of human beings because of their every day interaction with us. The assessment of our psychological traits is a useful tool when we require them to simulate empathy. Since the creation of social media platforms, numerous studies dealt with measuring personality traits by gathering users’ information from their social media profiles. Real world applications showed how natural language processing combined with supervised machine learning algorithms are effective in this field. These applications have some limitations such as focusing on English text only and not considering polysemy in text. In this paper, we propose a multilingual model that handles polysemy by analyzing sentences as a semantic ensemble of interconnected words. The proposed approach processes Facebook posts from the myPersonality dataset and it turns them into a high-dimensional array of features, which are then exploited by a deep neural network architecture based on transformer to perform regression. We prove the effectiveness of our work by comparing the mean squared error of our model with existing baselines and the Kullback–Leibler divergence between the relative data distributions. We obtained state-of-the-art results in personality traits estimation from social media posts for all five personality traits.
SPRING LEAF PHENOLOGICAL CHARACTERISTICS OF COMMON LANDSCAPE TREE SPECIES IN NYINGCHI PREFECTURE, TIBET, CHINA

Studying the phenological characteristics of landscape trees can determine the optimal afforestation time for local landscaping, while also providing a theoretical basis for garden design, plant configuration and garden phenology prediction. In order to grasp the leaf pheniological rhythm of common landscape tree species in Nyingchi Prefecture, optimize the garden plant configuration of Nyingchi Prefecture, 53 kinds of landscape tree species were selected as the object for continuous 5a parallel observation and analysis of their leaf phenology. The results showed that: the budding period lasts from early March to mid-April, and that of 20 species concentrates in late March. It is recommended that afforestation be completed before mid-April. The leaf expansion period lasts from early March to mid-June, and the peak period is from mid-April to early May. It is recommended to arrange the seasonal landscape according to the leaf expansion characteristics of the tree species. The 53 tree species were classified into 5 types based on leaf phenological characteristics. Finally, corresponding measures and suggestions were proposed for local garden afforestation and tree arrangement.
Organically Modified Montmorillonite as Nanoreactor to Improve the Grafting Degree of Maleic Anhydride onto Polypropylene

The application of an organically modified montmorillonite nanoreactor in the reactive extrusion process of the free radical grafting of maleic anhydride onto polypropylene (PP) can increase the MAH grafting degree on the PP. The mechanism of grafting was studied by using transmission electron microscopy and high temperature gel permeation chromatography. It was found that both the strong interactions between MAH and MMT surface and the encapsulation effect of active species confined in o-MMT improved the grafting degree.