Miracle-dz/UniFAR-FTUs huggingface dataset:
Oncogenic and Stemness Signatures of the High-Risk HCMV Strains in Breast Cancer Progression

Simple Summary Lately, human cytomegalovirus (HCMV) has been progressively implicated in carcinogenesis alongside its oncomodulatory impact. CMV-Transformed Human mammary epithelial cells (CTH) phenotype might be defined by giant cell cycling, whereby the generation of polyploid giant cancer cells (PGCCs) could expedite the acquisition of malignant phenotypes. Herein, the main study objectives were to assess the transformation potential in vitro and evaluate the obtained cellular phenotype, the genetic and molecular features, and the activation of cellular stemness programs of HCMV strains, B544 and B693, which were previously isolated from triple-negative breast cancer (TNBC) biopsies. The strains’ sensitivity to paclitaxel and ganciclovir combination therapy was evaluated. A unique molecular landscape was unveiled in the tumor microenvironment of TNBC harboring high-risk HCMV. Overall, the explicit oncogenic and stemness signatures highlight HCMV potential in breast cancer progression thus paving the way for targeted therapies and clinical interventions which prolong the overall survival of breast cancer patients. Abstract Background: Human cytomegalovirus (HCMV) oncomodulation, molecular mechanisms, and ability to support polyploid giant cancer cells (PGCCs) generation might underscore its contribution to oncogenesis, especially breast cancers. The heterogeneity of strains can be linked to distinct properties influencing the virus-transforming potential, cancer types induced, and patient’s clinical outcomes. Methods: We evaluated the transforming potential in vitro and assessed the acquired cellular phenotype, genetic and molecular features, and stimulation of stemness of HCMV strains, B544 and B693, isolated from EZH2HighMycHigh triple-negative breast cancer (TNBC) biopsies. Therapeutic response assessment after paclitaxel (PTX) and ganciclovir (GCV) treatment was conducted in addition to the molecular characterization of the tumor microenvironment (TME). Findings: HCMV-B544 and B693 transformed human mammary epithelial cells (HMECs). We detected multinucleated and lipid droplet-filled PGCCs harboring HCMV. Colony formation was detected and Myc was overexpressed in CMV-Transformed-HMECs (CTH cells). CTH-B544 and B693 stimulated stemness and established an epithelial/mesenchymal hybrid state. HCMV-IE1 was detected in CTH long-term cultures indicating a sustained viral replication. Biopsy B693 unveiled a tumor signature predicting a poor prognosis. CTH-B544 cells were shown to be more sensitive to PTX/GCV therapy. Conclusion: The oncogenic and stemness signatures of HCMV strains accentuate the oncogenic potential of HCMV in breast cancer progression thereby leading the way for targeted therapies and innovative clinical interventions that will improve the overall survival of breast cancer patients.
Formative quizzes in the learning of sensors and transducers: Online vs. paper based

In some previous research studies, quite successful results have been obtained in using online tools to increase students' academic achievement. In many fields; the benefits of online formative quizzes have been widely recognized by educators. However, there is little research determining whether weekly formative online exams affect students' academic achievement, especially in engineering courses. In this quasi‐experimental study, it was investigated whether the weekly quiz application method had an effect on students' academic achievement in an engineering course. One hundred and ninety sophomores participated in the study. Although the experimental group (n = 81) used the quizzes prepared on the Course Portal online to learn the Sensors and Transducers Unit, the control group (n = 109) solved the quizzes in the textbook on a paper‐pencil basis. After the online quizzes were solved, the experimental group was given which questions they answered incorrectly and the related video link of these incorrectly answered questions, and the relevant section of the book was given by the Course Portal as feedback. The pretest and posttest data of the students were obtained, and analysis of covariance was utilized as the analysis method to reveal the answer to the study question. The statistical analysis of the students' average achievement scores in the posttest (midterm exam) showed that the experimental group's average achievement score was significantly better than the control group. Results show that online weekly exams have significant effects on students' academic achievement. Weekly online quizzes are recommended to engineering lecturers as they offer students to improve their students' academic success.
India’s Evolving Neoliberal Regime of Dispossession: From the Anti-SEZ Movement to the Farm Law Protests

What do the protests against the farm laws of the Modi regime tell us about the trajectory of neoliberalisation in India? In this article, we address this question through a comparative analysis of the farm law protests and movements against land dispossession that mushroomed in many parts of India in the wake of the passing of India's SEZ Act in 2005. Both movements have explicitly targeted neoliberal policies that aggressively sought to remove obstacles to capitalist accumulation. However, the two movements are separated by roughly 15 years, and in effect target two distinctly different forms of dispossession—one predominantly coercive, the other predominantly market-driven. This begs questions as to whether the emergence of the farm law protests is indexical of new shifts in Indian neoliberalism? We argue that the answer to this question is a qualified yes. Through comparison and discussion of anti-dispossession struggles and the anti-farm laws protests, carried out in dialogue with the literature on regimes of dispossession, we develop a heuristic periodisation of Indian neoliberalisation and argue that the now-repealed farm laws and the strong farmers' resistance to them are indexical of India moving towards a 'rollover' form of neoliberalism.
“ Evaluation of the Effect of Two Different Concentration of Arginine on Fluoride Uptake by Demineralized Enamel Surfaces” in vitro study

Introduction: Arginine is a natural component of human saliva, which has recently been incorporated in dentifrices treating teeth sensitivity and acts as a protective factor against caries. Aim of the study: This study evaluated the effect of two different concentrations of arginine; 2.5% and 8% on fluoride uptake by demineralized enamel surfaces. Methods: 80 specimens obtained from 40 human premolars were divided randomly into 4 equal groups (n=20 per group): (GI=negative control), (GII=positive control) treated by sodium fluoride (NaF500 ppmf), group III treated by combination of sodium fluoride solution (NaF 500 ppmf)+arginine solution (2.5%) and group IV treated by combination of sodium fluoride solution (NaF 500 ppmf)+arginine solution (8%). Microhardness was tested using Vickers microhardness test, in addition to imaging using environmental scanning electron microscope (ESEM) and minerals content was assessed using energy dispersive X-ray spectroscopy (EDX). Statistical analysis was performed utilizing Kolmogorov-Smirnov and Shapiro-Wilk tests for normality of data, Levene’s tests for homogeneity and one-way ANOVA with Bonferroni post hoc tests for the evaluation of statistical significance among the groups. Results: Highest mean microhardness was in group III (370.58±12.14) and group IV (370.22±8.24). An increase in mineral density was found in group IV followed by group III, then group II and group I as revealed by ESEM. Data analysis showed increase in fluoride concentration in group III followed by group IV, group II and group I with a mean value (17.59±1.33), (14.62±1.91), (13.57±2.29) and (14.32±2.13) respectively. Conclusion: Fluoride uptake of demineralized enamel is increased when using both concentrations of arginine (2.5% and 8%). Arginine modulates areas of mineralized deposits and overall refinement of enamel ultrastructure.
Therapeutic Potential of Leaves from Fridericia chica (Bonpl.) L. G. Lohmann: Botanical Aspects, Phytochemical and Biological, Anti-Inflammatory, Antioxidant and Healing Action

Plants of the species Fridericia chica (Bonpl.) L. G. Lohmann (Bignoniaceae), which are widely distributed in Brazil and named crajiru in the state of Amazonas, are known in folk medicine as a traditional medicine in the form of a tea for the treatment of intestinal colic, diarrhea, and anemia, among other diseases. The chemical analysis of extracts of the leaves has identified phenolic compounds, a class of secondary metabolites that provide defense for plants and benefits to the health of humans. Several studies have shown the therapeutic efficacy of F. chica extracts, with antitumor, antiviral, wound healing, anti-inflammatory, and antioxidant activities being among the therapeutic applications already proven. The healing action of F. chica leaf extract has been demonstrated in several experimental models, and shows the ability to favor the proliferation of fibroblasts, which is essential for tissue repair. The anti-inflammatory activity of F. chica has been clearly demonstrated by several authors, who suggest that it is related to the presence of 3-deoxyanthocyanidins, which is capable of inhibiting pro-inflammatory pathways such as the kappa B (NF-kB) nuclear transcription factor pathway. Another important effect attributed to this species is the antioxidant effect, attributed to phenolic compounds interrupting chain reactions caused by free radicals and donating hydrogen atoms or electrons. In conclusion, the species Fridericia chica has great therapeutic potential, which is detailed in this paper with the objective of encouraging new research and promoting the sum of efforts for the inclusion of herbal medicines in health systems around the world.
On the equilibrium state of two rotating charged masses in General Relativity

This paper is a direct continuation of our old publication where it was found the exact solution of the Einstein-Maxwell equations for two static sources of Reissner-Nordstrom type in the state of the physical equilibrium. Here we present the exact solution of these equations for the case of two rotating charged sources and we proved the existence of the physical equilibrium state also for this general case.
Abell 2146: riding the wake of a merging galaxy cluster

The Chandra X-ray observation of the galaxy cluster Abell 2146 (Russell et al. 2010) has revealed the supersonic passage of a subcluster through the cluster center producing two Mach 2 shock fronts and a gas structure similar to the bullet cluster (Markevitch et al. 2002). We report on integral field observations of the brightest cluster galaxy located behind one of the shock fronts and in the wake of the ram pressure stripped core. Crawford et al. (1999) have detected the optical emission line gas surrounding the brightest cluster galaxy. The galaxy has a large Hα luminosity above 1042 erg s−1 and a large star formation rate (200 solar masses per year, O’Dea et al. 2008). The unique location of the brightest cluster galaxy behind the shock front and offset from the X-ray cool core allows us to investigate the effect of turbulence behind the shock front and disruption of the cooling core on the cool 104 K gas in the system.
Assessment of Awareness And Knowledge among Medical Students Regarding Radiation Exposure from Common Diagnostic Imaging Procedures

Objective: to assess the awareness and knowledge of our medical students regarding dose levels of imaging procedures and radiation safety issues, and to conclude how the curriculum of clinical radiology in the college medical program impacts such knowledge. Subjects and methods: this is a cross-sectional study conducted among 150 medical students in Alkindy College of Medicine between January 2021 to July 2021, regardless of their age or gender. The study included six grades according to the year 2020-2021. A questionnaire consisting of 12 multiple-choice questions was conducted via an online survey using Google Forms. The questions were divided into two parts (awareness concerning issues of radiation protection, and information about dose levels of frequent radiological investigations). Results: Regarding their radiology knowledge, about one-third of all participants rated as average. Students who had not established training in radiology chose the inappropriate choice more often than individuals who had received training. Also, students without instruction/ teaching in diagnostic clinical radiology were more likely to connect MRI and ultrasound with an increased cancer possibility compared with those students receiving radiology teaching. About the desired educational method, 32% wanted a tutorial or workshops, 29% wanted a learning module, 25% chose a case study and 14% chose a lecture. Conclusion: With increasing years in medical school, the student’s alertness demonstrates better performance regarding the radiation exposures in imaging diagnosis. The greater part of medical students has inadequate knowledge about different aspects of radiation sources, hazard, and their safety. We think that adding more theoretical and practical programs to the educational radiology curriculum will advance awareness of radiation safety and increase knowledge among medical students regarding the doses of radiological examinations.
Comparative Transcriptomic Analysis Identifies a Range of Immunologically Related Functional Elaborations of Lymph Node Associated Lymphatic and Blood Endothelial Cells

Lymphatic and blood vessels are formed by specialized lymphatic endothelial cells (LEC) and blood endothelial cells (BEC), respectively. These endothelial populations not only form peripheral tissue vessels, but also critical supporting structures in secondary lymphoid organs, particularly the lymph node (LN). Lymph node LEC (LN-LEC) also have been shown to have important immunological functions that are not observed in LEC from tissue lymphatics. LN-LEC can maintain peripheral tolerance through direct presentation of self-antigen via MHC-I, leading to CD8 T cell deletion; and through transfer of self-antigen to dendritic cells for presentation via MHC-II, resulting in CD4 T cell anergy. LN-LEC also can capture and archive foreign antigens, transferring them to dendritic cells for maintenance of memory CD8 T cells. The molecular basis for these functional elaborations in LN-LEC remain largely unexplored, and it is also unclear whether blood endothelial cells in LN (LN-BEC) might express similar enhanced immunologic functionality. Here, we used RNA-Seq to compare the transcriptomic profiles of freshly isolated murine LEC and BEC from LN with one another and with freshly isolated LEC from the periphery (diaphragm). We show that LN-LEC, LN-BEC, and diaphragm LEC (D-LEC) are transcriptionally distinct from one another, demonstrating both lineage and tissue-specific functional specializations. Surprisingly, tissue microenvironment differences in gene expression profiles were more numerous than those determined by endothelial cell lineage specification. In this regard, both LN-localized endothelial cell populations show a variety of functional elaborations that suggest how they may function as antigen presenting cells, and also point to as yet unexplored roles in both positive and negative regulation of innate and adaptive immune responses. The present work has defined in depth gene expression differences that point to functional specializations of endothelial cell populations in different anatomical locations, but especially the LN. Beyond the analyses provided here, these data are a resource for future work to uncover mechanisms of endothelial cell functionality.
The Effect of Cell Salvage on Bleeding and Transfusion Needs in Cardiac Surgery

Introduction Cell salvaging is well established in the blood management of cardiac patients, but there remain some concerns about its effects on perioperative bleeding and transfusion variables. This randomized controlled study investigated the potential effects of the centrifuged end-product on bleeding, transfusion rates, and other transfusion-related variables in adult cardiac surgery patients submitted to extracorporeal circulation. Materials and Methods Patients were randomly chosen to receive (cell-salvage group, 99 patients) or not to receive (control group, 110 patients) the centrifuged product of a cell salvage apparatus. Bleeding and transfusion rates according to the universal definition of perioperative bleeding (UDPB) classification, postoperative hemoglobin, coagulation, and oxygenation indices were recorded and compared between the groups. Results Both groups had almost identical bleeding and transfusion rates (median value: 2 units of red blood cells (RBC) and no units of fresh frozen plasma (FFP) and platelets (PLT) for both groups, p > 0.05). Patients in the cell-salvage group presented slightly higher hemoglobin concentrations (10.6 ± 1.1 vs. 10.1 ± 1.7 g/dL, p < 0.05, respectively) and a tendency towards better oxygenation indices (PaO2/FiO2: 241 ± 94 vs. 207 ± 84, p=0.013) in the postoperative period albeit with a tendency for prolongation of prothrombin time (INR: 1.31 ± 0.18 vs. 1.26 ± 0.12, p=0.008). Conclusion Within the study's constraints, the perioperative use of the cell salvage concentrate does not seem to affect bleeding or transfusion variables, although it could probably ameliorate postoperative oxygenation in adult cardiac surgery patients. A tendency to promote coagulation disturbances was detected.
Symmetrische Brücken und Knotentheorie zu den Dynkin-Diagrammen vom Typ B

Classical knot theory belongs to the series An of Dynkin-diagrams. There exist analogous theories belonging to the other series and to more general series of Coxeter-Dynkin-diagrams. In this first note we present (as an introduction to area) some basic results for the series Bn. This covers the following topics: Temperley-Lieb-algebras, Hecke-algebras, Kauffmanfunctor and state sums, braid groups, Markov-traces, writhe, Jonespolynomials, skein-relations and Poincae-polynomials of Weyl-groups.
Belief in a Dangerous World Does Not Explain Substantial Variance in Political Attitudes, But Other World Beliefs Do

Decades of research suggest a correlation between belief in a dangerous world and political conservatism. However, research relied on a scale that may overemphasize certain types of dangers. Furthermore, few other world beliefs have been investigated, such that fundamental worldview differences between liberals and conservatives remain largely unknown. A preregistered study of nine samples (N = 5,461; mostly US Americans) found a negligible association between a newly improved measure of generalized dangerous world belief and conservatism, and that the original scale emphasized certain dangers more salient to conservatives (e.g., societal decline) over others most salient for liberals (e.g., injustice). Across many measures of political attitudes, other world beliefs—such as beliefs that the world is Hierarchical, Intentional, Just, and Worth Exploring—each explained several times more variance than dangerous world belief. This suggests the relevance of dangerous world belief to political attitudes has been overstated, and examining other world beliefs may yield insights.
Research on Car License Plate Recognition Based on Improved YOLOv5m and LPRNet

The application of license plate recognition technology is becoming more and more extensive. In view of the current practical requirements for the recognition accuracy and real-time performance of license plate recognition system in complex scenes, the existing target detection methods and license plate recognition methods are studied, and a car license plate recognition method based on improved YOLOv5m and LPRNet model is proposed. On the basis of studying the YOLOv5m algorithm and the image features of the car license plate, the YOLOv5m algorithm is improved from three aspects: the K-means++ algorithm is used to improve the matching degree between the anchor frame and the detection target, the DIOU loss function is used to improve the NMS method, and the feature map with $20\times 20$ is removed to reduce the number of detection layers. A lightweight LPRNet network is used to realize license plate character recognition without character segmentation. Combining the improved YOLOv5m algorithm with LPRNet network, a license plate recognition system based on IYOLOv5m-LPRNet model is designed. The experimental results show that the average recognition accuracy of license plates in front, tilt, night and strong light interference scenes is more than 98%; Compared with the models of YOLOv3-LPRNet, YOLOv4-LPRNet, YOLOv5s-LPRNet and YOLOv5m-LPRNet, the recognition accuracy and recall rate of this method are improved, reaching 99.49% and 98.79% respectively; The mAP of this method is also the highest, reaching 98.56%; In terms of recognition speed, this method is also faster than the other four methods, and the number of pictures processed per second is increased by 5 compared with the YOLOv5m-LPRNet model. Therefore, the improved license plate recognition method in this paper performs well in robustness and speed.
Severe COVID-19 Infection in Post Renal Transplant Recipients: A Single Centre Report

Kidney transplant recipients are immunocompromised and have been under the spotlight during the COVD-19 pandemic. In our ICU 27.7% of patients received remdesivir as compared to the previous study in which no remdesivir therapy was administered. We did not report any deterioration in renal function secondary to its administration but improved outcome in patients administered the same. Survival rates of patients are thus higher in our subset (53.6%), which included patients with only severe disease.
Microwave-frequency loss and dispersion in ferroelectric Ba0.3Sr0.7TiO3 thin films

We report on broadband microwave-frequency measurements of epitaxial ferroelectric Ba0.3Sr0. 7TiO3 thin films that reveal systematic increases in the loss and dispersion as the frequency increases toward 40 GHz. Our analysis provides evidence that the origin of this increased loss and dispersion is the direct coupling of microwave energy into a broad distribution of damped soft-phonon modes. We believe that nanometer-sized polar regions in the thin films play a role in this process, resulting in lattice-dynamical loss mechanisms that extend several decades in frequency below the frequency of the soft mode in these thin-film materials.
Job Motivation, Burnout and Turnover Intention during the COVID-19 Pandemic: Are There Differences between Female and Male Workers?

The working conditions during COVID-19 highlight the relevance of workers and their occupational health and well-being. The pandemic has caused adverse effects on workers and sharpened social and economic problems, such as a gender gap. In this study, with a multisector sample of 1044 Ecuadorian workers, we present a gender analysis where we evaluate how burnout can mediate the relationship between motivation and workers’ intention to leave their jobs in the COVID-19 context. To test the proposed hypothesis, structural equation model (SEM) was used. In the proposed conceptual model, turnover intention was considered as the dependent variable, the two dimensions of motivation (intrinsic and extrinsic) were the independent variables and burnout was tested as a mediating variable. Consistent with pre-COVID-19 research, our findings confirm the incidence of job motivation on burnout and turnover intention. Additionally, through Sobel’s criteria, we determine that burnout has a mediating effect between job motivation and turnover intention. In terms of gender, we find different results for female and male workers through critical ratios. Our study indicates that female and male workers’ burnout and turnover intentions levels are different when intrinsic motivation is present. In contrast to pre-COVID-19 studies that indicated no gender differences on these variables, we associate these results to gender roles in lockdown conditions during the pandemic.