Miracle-dz/UniFAR-FTUs huggingface dataset:
Lithology of EM1 Reservoir Revealed by Fe Isotopes of Continental Potassic Basalts

The origin of EM1 (Enriched Mantle 1) reservoir, initially defined by the ocean island basalts (OIBs) with extremely low 143Nd/144Nd and 206Pb/204Pb, has been long debated, because melting of the ambient refractory peridotite along with the EM1 component will dilute the “EM1 fingerprints” recorded in these rocks. Comparing to the OIBs, Cenozoic potassic basalts from northeast China, the typical EM1‐type basalts in continental region, are formed at a lower‐degree melting, and therefore have the chance to preserve more information of the EM1 component. Here high‐precision Fe isotopes of these potassic basalts are reported to constrain the source lithology. Their δ57Fe (0.15–0.28‰) are positively correlated with the K2O, SiO2, K/U, and Rb/Y, and negatively correlated with the εNd and δ26Mg, forming binary mixing arrays. One endmember is the inferred EM1 reservoir, whereas the other is the local lithospheric mantle. Major elemental compositions of the melts released from the EM1 component resemble those sediment‐derived experimental melts. Combining with their heavier Fe isotopes and higher Zn/Fe ratios relative to those mid‐ocean ridge basalts (MORBs), an eclogitic source of these potassic basalts is therefore proposed to account for these features. Differing from the most conventional thinking of the metasomatized, phlogopite‐bearing lithospheric mantle, we argue that the EM1 component in the source of continental potassic basalts are composed of ancient subducted crustal materials (i.e., recycled sediment ± oceanic crust). This deep EM1 component will transform into eclogite and release high‐SiO2 potassic melts when ascending to the shallow asthenosphere.
Mean-Field Model for Protein Folding

We consider a model of a protein, in which the contact interaction between any pair of amino-acids along the chemical sequence is a quenched random variable. At high dimension, the model is equivalent to a Potts spin glass. The protein has a folding transition, between a Brownian phase at high temperature and a collapsed glassy phase at low temperature. At low dimensions, this equivalence does not hold, and we propose an approximate solution to the mean-field equations.
AN ESTIMATE FOR POLYNOMIALS ON ANALYTIC SETS

Let be a connected, analytic (in general, not closed) subset of the complex space and let be a compact set which is not pluri-polar in . In this article it is proved that the extremal function is locally bounded on if and only if belongs to some algebraic set of the same dimension as . Moreover, it is shown that for an algebraic set in a neighborhood of any ordinary point the function can be represented as the limit of an increasing sequence of maximal functions. Bibliography: 10 titles.
Normal Sections and Direct Product Decompositions

Abstract In any finitely complete category, there is an internal notion of normal monomorphism. We give elementary conditions guaranteeing that a normal section s: Y → X of an arrow f: X → Y produces a direct product decomposition of the form X ≃ Y × W. We then show how these conditions gradually vanish in various algebraic contexts, such as Maltsev, protomodular and additive categories.
A unified approach to eigenvalue bounds of the solution of the Riccati equation

Abstract A unified approach is introduced to measure the eigenvalue bounds of the algebraic Riccati equation. Via deriving eigenvalue bounds of the solution of the socalled “unified Riccati equation”, new upper and lower extreme eigenvalue bounds for the solutions of the continuous and discrete Riccati matrix equations are proposed. It is shown that some of the presented bounds for the continuous Riccati equation are sharper than the majority of existing results and the upper bound for the maximum eigenvalue of the solution of the discrete Riccati equation is less restrictive than parallel results in some cases.
CHEMICAL ENRICHMENT IN THE CARBON-ENHANCED DAMPED Lyα SYSTEM BY POPULATION III SUPERNOVAE

We show that the recently observed elemental abundance pattern of the carbon-rich metal-poor damped Lyα (DLA) system is in excellent agreement with the nucleosynthesis yields of faint core-collapse supernovae of primordial stars. The observed abundance pattern is not consistent with the nucleosynthesis yields of pair-instability supernovae. The DLA abundance pattern is very similar to that of carbon-rich extremely metal-poor (EMP) stars, and the contributions from low-mass stars and/or binary effects should be very small in DLAs. This suggests that chemical enrichment by the first stars in the first galaxies is driven by core-collapse supernovae from ∼20 to 50 M☉ stars and also supports the supernova scenario as the enrichment source of EMP stars in the Milky Way Galaxy.
The Relationship Between Perceptions of Leader Hypocrisy and Employees’ Knowledge Hiding Behaviors: Testing a Moderated Mediation Model

Purpose Knowledge-sharing is critical for the survival and development of today’s organization, but employees are not always willing to share their knowledge and sometimes even hide it intentionally or unintentionally. Taken from the leadership perspective, this paper aims to investigate the influence of leader hypocrisy on employees’ knowledge-hiding behaviors. Drawing on the self-determination theory (SDT), this paper explores the mediating role of basic psychological needs satisfaction, as well as the moderating effect of employees’ interdependent self-construal on the relationship between basic psychological needs satisfaction and knowledge-hiding behaviors. The moderated mediation effect is also tested. Methods The data were collected from companies located in mainland China. The data sample for analysis consists of 336 employees. Hierarchical regression analysis was adopted to test the hypotheses of our proposed model. Results Leader hypocrisy are positively related to knowledge-hiding behaviors (b = 0.490, p < 0.01). Basic psychological needs satisfaction plays a partial mediating role in such relationship (b =0.118, [0.056, 0.210]). The interdependent self-construal moderates the relationship between basic psychological needs satisfaction and knowledge-hiding behaviors (b = 0.134, p < 0.01), as well as the moderated mediation effect (BootSE = 0.018, [−0.083, −0.009]). Conclusion The results show that leader hypocrisy is positively related to knowledge-hiding behaviors, and basic psychological needs satisfaction partially mediates such relationship. The interdependent self-construal weakens the negative relationship between basic psychological needs satisfaction and knowledge hiding.
The Evolution of Human Development Through the Eyes of ICT in Developing Countries Based on Panel Data from 2007 to 2017

This paper examines the role of information communication technologies (ICT) in human development (HDI) and its three sub-dimensions in developing countries. ICT has become one of the most essential tools in the development community to enable countries to achieve specific development goals, including education, health, economic opportunities and poverty eradication. Comparing the effect of ICT on, HDI and its sub-dimensions, over the period 2007–2017 and testing the relationship between them has been done using panel data models. The results show that there was a positive correlation between ICT, HDI and its three sub-dimensions: 1% increase in IDI leads to 0.082% growth in HDI; the coefficients of income, education and health indices in developing countries are positive and statistically significant; and every 1% increase in the IDI index will drive income, education and health. The indicators increased by 0.014%, 0.029% and 1.34% respectively. This analysis suggests that ICTs promote human development in developing countries. A low’s positive impact on income indices, however, is not significant for developing countries, which have high health and education indices.
Finite element simulation of the inertia welding of two similar parts

A complete thermo‐mechanical model for the simulation of the inertia welding process of two similar parts is described. The material behaviour is represented by an incompressible viscoplastic Norton—Hoff law in which the rheological parameters are dependent on temperature. The friction law was determined experimentally and depends on the prescribed pressure and the relative rotating velocity between the two parts. The mechanical problem is solved considering the virtual work principle including inertia terms. The computation of the three components of the velocity field such as radial, longitudinal and rotational velocity, in an axisymmetric approximation allows to take into account the torsional effects. The domain is updated based on a Lagrangian formulation. The non‐linear heat transfer equation with boundary conditions (convection, radiation and friction flux) is solved separately for each time step. Error estimators on mechanical and thermal computation are devised to adapt the mesh in an automatic w.
HOMOGENEOUS ISOPARAMETRIC HYPERSURFACES IN SPHERES WITH FOUR DISTINCT PRINCIPAL CURVATURES AND MOMENT MAPS

We study relations between moment maps of Hamiltonian actions and iso- parametric hypersurfaces in spheres with four distinct principal curvatures. In this paper, we deal with the isoparametric hypersurfaces given by the isotropy representations of compact irreducible Hermitian symmetric spaces of classical type and of rank two. We show that such isoparametric hypersurfaces can be obtained by moment maps. More precisely, cer- tain squared-norms of moment maps coincide with Cartan-Münzner polynomials, which are deﬁning-equations, of above isoparametric hypersurfaces.
Population prevalence of myopia, glasses wear and free glasses acceptance among minority versus Han schoolchildren in China

Aim To measure myopia, glasses wear and free glasses acceptance among minority and Han children in China. Methods Visual acuity testing and questionnaires assessing ethnicity, study time, and parental and teacher factors were administered to a population-based sample of 9–12 year old minority and Han children in Yunnan and Guangdong, and their teachers and parents. Refraction was performed on children with uncorrected visual acuity (VA) < = 6/12 in either eye, and acceptance of free glasses assessed. Main outcome measures Baseline myopia (uncorrected visual acuity < = 6/12 in > = 1 eye and spherical equivalent refractive power < = -0.5D in both eyes); baseline glasses wear; free glasses acceptance. Results Among 10,037 children (mean age 10.6 years, 52.3% boys), 800 (8.0%) were myopic, 4.04% among Yunnan Minority children (OR 0.47, 95%CI 0.33, 0.67, P<0.001), 6.48% in Yunnan Han (OR 0.65, 95%CI 0.45, 0.93, P = 0.019), 9.87% in Guangdong Han (Reference). Differences remained significant after adjusting for study time and parental glasses wear. Difference in baseline glasses ownership (Yunnan Minority 4.95%, Yunnan Han 6.15%, Guangdong Han 15.3%) was not significant after adjustment for VA. Yunnan minority children (71.0%) were more likely than Yunnan Han (59.6%) or Guangdong Han (36.8%) to accept free glasses. The difference was significant after adjustment only compared to Guangdong Han (OR 3.34, 95% CI 1.62, 6.90, P = 0.001). Conclusion Myopia is more common among Han children and in wealthier Guangdong. Baseline differences in glasses wear could be explained by student, teacher and parental factors. Yunnan Minority children were more likely to accept free glasses.
Single-cell intratumoral stemness analysis reveals the involvement of cell cycle and DNA damage repair in two different types of esophageal cancer

Intratumoral heterogeneity, particularly the potential cancer stemness of single cancer cells, has not yet been fully elucidated in human esophageal cancer. Single-cell transcriptome sequencing of two types of esophageal adenocarcinoma (EAC) and two types of esophageal squamous cell carcinoma (ESCC) tissues was performed, and the intratumoral cancer stemness of the types of esophageal cancer were characterized at the single-cell level in the present study. By comparing the transcriptomic profiles of single cancer cells with high and low stemness in individual patients, it was revealed that the overexpression of cell cycle-associated genes in EAC cells was highly correlated with stemness, whereas overexpression of genes involved in the signaling pathways of DNA replication and DNA damage repair was significantly correlated with stemness in ESCC. High expression of these stemness-associated genes was correlated with poor prognosis of patients. Additionally, poly [ADP-ribose] polymerase(PARP)4 was identified as a novel cancer stemness-associated gene in ESCC and its association with survival was validated in a cohort of 121 patients with ESCC. These findings have profound potential implications for the use of cell cycle inhibitors in EAC and PARP inhibitors in ESCC, which may provide novel mechanistic insights into the plasticity of esophageal cancer.
Periodic changes in carbon and nitrogen in Vertisols under organic, inorganic, and integrated nutrient management

An experiment with seven treatments and three replications was established in a completely randomized design to assess the effect of gliricidia green leaf manuring on the mineralization of nitrogen and carbon in the soil during kharif 2014-15 in Dr. Panjabrao Deshmukh Krishi Vidyapeeth’s Department of Soil Science and Agricultural Chemistry, Akola. The seven treatments comprised absolute control, two treatments of sole chemical fertilizers, two treatments of sole organics, and two treatments of integrated application of chemical fertilizers and gliricidia green leaves. The periodical (15 days interval) mineralization of nitrogen in the form of ammoniacal and nitrate nitrogen and carbon in the form of organic carbon and permanganate oxidizable carbon in soil were studied. The results indicate that the higher mineralization of nitrogen and carbon was recorded up to 45 days of incubation and it declined at subsequent (60 and 75 days) intervals, indicating that more than 60% of mineralization took place up to 45 days of incubation. Further, the higher mineralization of nitrogen and carbon was observed with the application of 50% RDN(Gl) + 50% N(Inorg) + 100% P + 25 kg K ha-1 (T7), followed by 50% RDN(Gl) + 50% N(Inorg) + 100% P (T6) and 100% NPK(T3).
Use of routine ureteral stents in cesarean hysterectomy for placenta accreta

Abstract Objective: To evaluate benefits of use of ureteral stents in association with cesarean hysterectomy in case of placenta accreta. Methods: This was a single center, cohort study. Clinical records of singleton pregnancies with placenta accreta who underwent cesarean hysterectomy were included in the study. For this study, pregnancies with diagnoses of placenta accreta, increta, or percreta were considered under the umbrella term of placenta accreta. For all women with placenta accreta, delivery was planned via cesarean hysterectomy at 340–356 weeks, without any attempt to remove the placenta. Reasons for earlier delivery included vaginal bleeding and spontaneous onset of labor. The primary outcome was the incidence of unintentional urinary tract injury. Outcomes were compared in a cohort of women who had planned the placement of ureteral stents and in those who did not. Results: Forty-four singleton gestations with confirmed placenta accreta at the time of cesarean hysterectomy were included in the study. Twenty-four (54.5%) of the included women had the placing of ureteral stents prior to cesarean, while 20 (45.5%) did not. At histological confirmation, most of them had placenta accreta (17/44, 38.6%), 14 placenta increta (31.8%), and 13 placenta percreta (29.6%). Urinary tract injuries occurred in eight cases (18.2%), six in the ureteral stents and two in the non-ureteral stents group (25 versus 10%; p = .21). All the injuries were bladder injuries, while no cases of ureteral injury were recorded. All injuries were recognized intraoperatively. Conclusion: In case of placenta accreta, the use of ureteral stents in association with cesarean hysterectomy does not reduce the risk of urinary tract injury.
AXL knockdown gene signature reveals a drug repurposing opportunity for a class of antipsychotics to reduce growth and metastasis of triple-negative breast cancer

Triple-Negative Breast Cancer (TNBC) is an aggressive cancer subtype that is associated with a poor prognosis due to its propensity to form metastases. The receptor tyrosine kinase AXL plays a role in tumor cell dissemination and its expression in breast cancers correlates with poor patient survival. Here, we explored whether already used drugs might elicit a gene signature similar to that seen with AXL knockdown in TNBC cells and which could, therefore, offer an opportunity for drug repurposing. To this end, we queried the Connectivity Map with an AXL gene signature which revealed a class of dopamine receptors antagonists named phenothiazines (Thioridazine, Fluphenazine and Trifluoperazine) typically used as anti-psychotics. We next tested if these drugs, similarly to AXL depletion, were able to limit growth and metastatic progression of TNBC cells and found that phenothiazines are able to reduce cell invasion, proliferation, viability and increase apoptosis of TNBC cells in vitro. Mechanistically, these drugs did not affect AXL activity but instead reduced PI3K/AKT/mTOR and ERK signaling. When administered to mice bearing TNBC xenografts, phenothiazines were able to reduce tumor growth and metastatic burden. Collectively, these results suggest that these antipsychotics display anti-tumor and anti-metastatic activity and that they could potentially be repurposed, in combination with standard chemotherapy, for the treatment of TNBC.
Epilepsy-Related Direct Medical and Direct Non-Medical Cost in Adult Patients Living with Epilepsy at a Tertiary Neurology Center in Rwanda

Objective Up to one in four patients living with epilepsy (PwE) mentions financial constraints as a reason for loss to follow-up at the Ndera tertiary neuropsychiatry hospital. Therefore, we evaluated the annual direct medical cost (DMC) and direct non-medical cost (DnMC) of epilepsy and calculated costs assuming different follow-up frequency. Materials and Methods DMC data were obtained from a descriptive retrospective study of medical records, pharmacy dispensation and hospital logs of PwE, following their initial consultation in 2018 and who adhered to the normal clinical practice of monthly consultations for one year. DnMC data were collected through structured interviews of PwE in a cross-sectional cohort in August 2020. DnMC included biomedical care costs (eg, transportation, hospitality) and non-biomedical costs (traditional healer visits). We report weighted means for total costs, health insurance costs, and out-of-pocket costs (OoP). Results Mean annual total cost was 389.4 US$, of which 226.2 US$ was covered by the Rwandan Health Insurance co-payment for DMC and 163.2 US$ was OoP paid by patients. Mean weighted annual DMC (n = 55) was 248.9 US$. Mean weighted annual DMC for medical consultations and antiseizure medication accounted for 30.7 US$ and 161.7 US$, respectively. Based on structured interviews (n = 69), mean weighted annual DnMC for biomedical care was 73.0 US$. Mean DnMC for traditional healer care was 67.6 US$. Weighted annual total OoP was 163.2 US$ or 20% of the GDP per capita. OoP consisted of 14% DMC co-payment, 45% biomedical DnMC, and 41% traditional healer DnMC. Conclusion Epilepsy-related costs at a tertiary center are an important economic burden for PwE and Rwandan Health Insurance. Biomedical and traditional healer DnMC constitute 86% of total OoP. Future prospective studies should evaluate outcomes and costs of reduced visit frequency, indirect costs, and costs of comorbidities.
Meta analysis with potentially correlated marketing study results

Across marketing studies, often ihe same hypothesis is tested many times. Study results, however, are not necessarily consistent. A meta analysis can be used to summarize results from the various Studies, investigating why they differ. One of the assumptions often made in a analysis is that the study results are independent of one another However, in many marketing analyses, different studies may share part of the same data set for the model estimation or one model could be subset of the other so that results could be potentially correlated, Yet resulting correlation coefficients are not available. For such cases, we suggest three estimators which do not require correlation information. We take a case of advertising analyses, using a Monte-Carlo simulation to evaluate how neglecting the potential correlation affects the result of a meta analysis with covariates. The results of the simulation study indicate that eliminating the variance due to random error in study effect, instead of the correlation, may have a significant effect on the performance of estimators, when a relatively small number of study results are combined. This suggests that the ordinary least square estimator, which ignores potential heterogeneity due to estimation error but considers the random error, would not be a bad choice for a meta analysis in view of its easy implementation.
Clostridium butyricum Can Promote Bone Development by Regulating Lymphocyte Function in Layer Pullets

Bone health problems are a serious threat to laying hens; microbiome-based therapies, which are harmless and inexpensive, may be an effective solution for bone health problems. Here, we examined the impacts of supplementation with Clostridium butyricum (CB) on bone and immune homeostasis in pullets. The results of in vivo experiments showed that feeding the pullets CB was beneficial to the development of the tibia and upregulated the levels of the bone formation marker alkaline phosphatase and the marker gene runt-related transcription factor 2 (RUNX2). For the immune system, CB treatment significantly upregulated IL-10 expression and significantly increased the proportion of T regulatory (Treg) cells in the spleen and peripheral blood lymphocytes. In the in vitro test, adding CB culture supernatant or butyrate to the osteoblast culture system showed no significant effects on osteoblast bone formation, while adding lymphocyte culture supernatant significantly promoted bone formation. In addition, culture supernatants supplemented with treated lymphocytes (pretreated with CB culture supernatants) stimulated higher levels of bone formation. In sum, the addition of CB improved bone health by modulating cytokine expression and the ratio of Treg cells in the immune systems of layer pullets. Additionally, in vitro CB could promote the bone formation of laying hen osteoblasts through the mediation of lymphocytes.