Miracle-dz/UniFAR-FTUs huggingface dataset:
An integrated transcriptomic cell atlas of human neural organoids

Neural tissues generated from human pluripotent stem cells in vitro (known as neural organoids) are becoming useful tools to study human brain development, evolution and disease. The characterization of neural organoids using single-cell genomic methods has revealed a large diversity of neural cell types with molecular signatures similar to those observed in primary human brain tissue. However, it is unclear which domains of the human nervous system are covered by existing protocols. It is also difficult to quantitatively assess variation between protocols and the specific cell states in organoids as compared to primary counterparts. Single-cell transcriptome data from primary tissue and neural organoids derived with guided or un-guided approaches and under diverse conditions combined with large-scale integrative analyses make it now possible to address these challenges. Recent advances in computational methodology enable the generation of integrated atlases across many data sets. Here, we integrated 36 single-cell transcriptomics data sets spanning 26 protocols into one integrated human neural organoid cell atlas (HNOCA) totaling over 1.7 million cells. We harmonize cell type annotations by incorporating reference data sets from the developing human brain. By mapping to the developing human brain reference, we reveal which primary cell states have been generated in vitro, and which are under-represented. We further compare transcriptomic profiles of neuronal populations in organoids to their counterparts in the developing human brain. To support rapid organoid phenotyping and quantitative assessment of new protocols, we provide a programmatic interface to browse the atlas and query new data sets, and showcase the power of the atlas to annotate new query data sets and evaluate new organoid protocols. Taken together, the HNOCA will be useful to assess the fidelity of organoids, characterize perturbed and diseased states and facilitate protocol development in the future.
Effect of Gibberellic, Salicylic Acids, and NPK Fertilizers on growth and chemical constituents of Rosemary plants (Rosmarinus officinalis L.).

This experiment conducted on rosemary plant (Rosmarinus officinalis L.), aimed to investigate the effect of gibberellic acid (GA3), salicylic acid (SA), and NPK fertilizer on growth and chemical constituents as well as determining the best concentration. After two weeks from planting the rooted cuttings in plastic pots were sprayed with the SA at three concentrations (0, 150 and 300 mg l-1), GA3 Sprayed with two concentrations (0, 400 mg l-1), and NPK sprayed as Nano NPK at concentrations (3 and 6 g l-1), the control plants were fertilized with regular fertilizer recommendation of NPK (200-N, 100-P, 50-K mg l-1). The results showed: The triple interaction among the three factors studied indicated that the plants which sprayed with 400 mg l-1 GA3, 300 mg l-1 SA, and 6 g l-1 nano NPK fertilizers gave the highest value number of branches 19.97 branch plant-1, volatile oil percent 1.626 %, and total chlorophyll content 32.70 mg g-1 f.w, whereas plant height increased to highest value at 400 mg l-1 GA3, 300 mg l-1 SA and 3 g l-1 nano NPK which reached to 38.30 cm, also production of volatile oil per plant increased at 400 mg l-1 GA3, 150 mg l-1 SA, and 6 g l-1 nano NPK fertilizers 0.947 ml plant-1. It appears that using those levels gave the best growth and development results on rosemary plant. Further research is needed to investigate whether the higher concentrations than used in this research will give the better parameters.
On the local well-posedness for a full-dispersion Boussinesq system with surface tension

In this note, we prove local-in-time well-posedness for a fully dispersive Boussinesq system arising in the context of free surface water waves in two and three spatial dimensions. Those systems can be seen as a weak nonlocal dispersive perturbation of the shallow-water system. Our method of proof relies on energy estimates and a compactness argument. However, due to the lack of symmetry of the nonlinear part, those traditional methods have to be supplemented with the use of a modified energy in order to close the a priori estimates.
A van der Waals pn heterojunction with organic/inorganic semiconductors

van der Waals (vdW) heterojunctions formed by two-dimensional (2D) materials have attracted tremendous attention due to their excellent electrical/optical properties and device applications. However, current 2D heterojunctions are largely limited to atomic crystals, and hybrid organic/inorganic structures are rarely explored. Here, we fabricate the hybrid 2D heterostructures with p-type dioctylbenzothienobenzothiophene (C8-BTBT) and n-type MoS2. We find that few-layer C8-BTBT molecular crystals can be grown on monolayer MoS2 by vdW epitaxy, with pristine interface and controllable thickness down to monolayer. The operation of the C8-BTBT/MoS2 vertical heterojunction devices is highly tunable by bias and gate voltages between three different regimes: interfacial recombination, tunneling, and blocking. The pn junction shows diode-like behavior with rectifying ratio up to 105 at the room temperature. Our devices also exhibit photovoltaic responses with a power conversion efficiency of 0.31% and a photoresponsivity of 22 mA/W. With wide material combinations, such hybrid 2D structures will offer possibilities for opto-electronic devices that are not possible from individual constituents.
Almost ℂp Galois representations and vector
bundles

Let $K$ be a finite extension of $\mathbb{Q}_p$ and $G_K$ the absolute Galois group. Then $G_K$ acts on the fundamental curve $X$ of $p$-adic Hodge theory and we may consider the abelian category $\mathcal{M}(G_K)$ of coherent $\mathcal{O}_X$-modules equipped with a continuous and semi-linear action of $G_K$. An almost $C_p$-representation of $G_K$ is a $p$-adic Banach space $V$ equipped with a linear and continuous action of $G_K$ such that there exists $d\in\mathbb{N}$, two $G_K$-stable finite dimensional sub-$\mathbb{Q}_p$-vector spaces $U_+$ of $V$, $U_-$ of $C_p^d$, and a $G_K$-equivariant isomorphism $V/U_+\to C_p^d/U_-$. These representations form an abelian category $\mathcal{C}(G_K)$. The main purpose of this paper is to prove that $\mathcal{C}(G_K)$ can be recovered from $\mathcal{M}(G_K)$ by a simple construction (and conversely) inducing, in particular, an equivalence of triangulated categories $D^b(\mathcal{M}(G_K))\to D^b(\mathcal{C}(G_K))$.
Clocks and dynamics in quantum models of gravity

We investigate how the quantum dynamics of gravitational models depends on the internal clock employed in quantisation. Our previous result on the quantum Friedmann–Lemaitre model (Małkiewicz 2015 What is dynamics in quantum gravity? (arXiv:1505.04730)) demonstrates that almost all physical predictions from quantum cosmological dynamics, e.g. the scale of the quantum bounce or the number of bounces, depend on the choice of internal clock. In the present paper we show that there exists an important prediction concerning the quantum dynamics which holds in all internal clocks. Namely, we prove that any quantum state asymptotically, i.e. away from a quantum interaction regime, admits a unique classical limit described by unique classical solutions irrespective of the internal clock used for the dynamical description of the given state. We demonstrate this property explicitly for the semiclassical Bianchi Type I model, which includes the semiclassical Friedmann–Lemaitre model of Małkiewicz (2015 What is dynamics in quantum gravity? (arXiv:1505.04730)) as a special case. Our methods include the theory of pseudo-canonical transformations and the phase space portraits based on coherent states. As a by-product of the pursuit of our main goal, we elaborate the semiclassical description of anisotropic singularity resolution.
Dynamical models of elliptical galaxies – I. Simple methods

We study dynamical models for elliptical galaxies, deriving the projected kinematic profiles in a form that is valid for general surface-brightness profiles and (spherical) total mass profiles, without the need for any explicit deprojection. We then show that an almost flat rotation curve, combined with modest velocity anisotropy, is already sufficient to recover the kinematic profiles of nearby ellipticals. As an application, we provide two different sets of mass estimators for elliptical galaxies, based on either the velocity dispersion at a specific location near the effective radius, or the aperture-averaged velocity dispersion. In the large aperture (virial) limit, mass estimators are naturally independent of anisotropy. The spherical mass enclosed within the effective radius $R_{\rm e}$ can be estimated as $2.4 R_{\rm e} \langle \sigma^{2}_{\rm p} \rangle/ G$, where $\langle \sigma^2_{\rm p} \rangle$ is the average of the squared velocity dispersion over a finite aperture. This formula does not depend on assumptions such as mass-follows-light, and is a compromise between the cases of small and large apertures sizes. Its general agreement with results from other methods in the literature makes it a reliable means to infer masses in the absence of detailed kinematic information. If on the other hand the velocity dispersion profile is available, tight mass estimates can be found that are independent of the mass-model and anisotropy profile (within $\approx$ 10% accuracy). Explicit formulae are given for small anisotropy, large radii and/or power-law total densities. Motivated by recent observational claims, we also discuss the issue of weak homology of elliptical galaxies, emphasizing the interplay between morphology and orbital structure.
The impact of source credibility and risk perception attitudes on Americans’ willingness to participate in contact tracing applications

ABSTRACT Contact tracing has emerged as one tool to communicate infection risks with the public during the COVID-19 pandemic. This study uses source credibility and the risk perception attitude framework to interpret how Americans responded to contact tracing messages from a technology company, employer, physician, or state government. Survey participants (n = 245) were generally positive towards a contact tracing message regardless of source. Participants with high risk perceptions and low efficacy beliefs responded more strongly to appeals from their company and their physician while the low risk-low efficacy group found the state government appeal more compelling. The results suggest that several sources delivering the same health message could engage people with different risk perceptions and efficacy beliefs.
SELF-SUSTAINED RECYCLING IN THE INNER DUST RING OF PRE-TRANSITIONAL DISKS

Observations of pre-transitional disks show a narrow inner dust ring and a larger outer one. They are separated by a cavity with no or only little dust. We propose an efficient recycling mechanism for the inner dust ring which keeps it in a steady state. No major particle sources are needed for replenishment. Dust particles and pebbles drift outwards by radiation pressure and photophoresis. The pebbles grow during outward drift until they reach a balanced position where residual gravity compensates photophoresis. While still growing larger they reverse their motion and drift inward. Eventually, their speed is fast enough for them to be destroyed in collisions with other pebbles and drift outward again. We quantify the force balance and drift velocities for the disks LkCa15 and HD 135344B. We simulate single-particle evolution and show that this scenario is viable. Growth and drift timescales are on the same order and a steady state can be established in the inner dust ring.
Dark Matter Redistribution Explains Galaxy Growth and Rotation Curve Development

There are significant discrepancies between observational evidence and the hierarchical galaxy formation theory with respect to the shape of dark matter halos, the correlation between galaxy characteristics, and galaxy evolutionary history. This paper introduces a modification to the hierarchical galaxy formation theory that hypothesizes that dark matter enters into highly elliptical orbits, and is therefore, effectively redistributed during the period of galactic nuclei activity. Adding this modification, the theory more accurately predicts the observed development history of galaxies and their resulting mature state. In particular, this modification predicts that galaxies grow in size, but not in mass, at an early time (~7 to 10 billion years ago), and develop their characteristic rotation curves which, at large radius, exhibit a relatively flat shape versus the expected Keplerian decline.
Theory for Baryon Number and Dark Matter at the LHC

We investigate the possibility to test the simplest theory for spontaneous baryon number violation at the Large Hadron Collider. In this context the baryon number is a local gauge symmetry spontaneously broken at the low scale through the Brout-Englert-Higgs mechanism. This theory predicts the existence of a leptophobic neutral gauge boson and a fermionic dark matter candidate with baryon number. We study the gauge boson and Higgs decays, and explore the connection between collider signatures and constraints coming from dark matter experiments. We point out an upper bound on the symmetry breaking scale using the relic density constraints which tells us that this model can be tested or ruled out at current or future collider experiments.
Multi-Brid Inflation and Non-Gaussianity

We consider a class of multi-component hybrid inflation models whose evolution may be analytically solved under the slow-roll approximation. We call it multi-brid inflation (or n-brid inflation where n stands for the number of inflaton fields). As an explicit example, we consider a two-brid inflation model, in which the inflaton potentials are of exponential type and a waterfall field that terminates inflation has the standard quartic potential with two minima. Using the δN formalism, we derive an expression for the curvature perturbation valid to full nonlinear order. Then we give an explicit expression for the curvature perturbation to second order in the inflaton perturbation. We find that the final form of the curvature perturbation depends crucially on how the inflation ends. Using this expression, we present closed analytical expressions for the spectrum of the curvature perturbation PS(k), the spectral index nS, the tensor to scalar ratio r, and the non-Gaussian parameter f local NL , in terms of the model parameters. We find that a wide range of the parameter space (nS ,r , f local NL ) can be covered by varying the model parameters within a physically reasonable range. In particular, for plausible values of the model parameters, we may have a large non-Gaussianity f local NL ∼ 10–100. This is in sharp contrast to the case of single-field hybrid inflation in which these parameters are tightly constrained.
Ramsey subsets of the space of
infinite block sequences of vectors

We study families of infinite block sequences of elements of the space $\FIN_k$. In particular we study Ramsey properties of such families and Ramsey properties localized to a selective or semiselective coideal. We show how the stable ordered-union ultrafilters defined by Blass, and Matet-adequate families defined by Eisworth in the case $k=1$ fit in the theory of the Ramsey space of infinite block sequences of finite sets of natural numbers.
Dynamic critical phenomena at a holographic critical point

We study time-dependent perturbations to a family of five-dimensional black hole spacetimes constructed as a holographic model of the QCD phase diagram. We use the results to calculate two transport coefficients, the bulk viscosity and conductivity, as well as the associated baryon diffusion constant, throughout the phase diagram. Near the critical point in the T-mu plane, the transport coefficients remain finite, although their derivatives diverge, and the diffusion goes to zero. This provides further evidence that large-N_c gauge theories suppress convective transport. We also find a divergence in the low-temperature bulk viscosity, outside the region expected to match QCD, and compare the results to the transport behavior of known R-charged black holes.
Anderson model out of equilibrium: Decoherence effects in transport through a quantum dot

The paper deals with the nonequilibrium two-lead Anderson model, considered as an adequate description for transport through a d-c biased quantum dot. Using a self-consistent equation-of-motion method generalized out of equilibrium, we calculate a fourth-order decoherence rate $\gamma^{(4)}$ induced by a bias voltage $V$. This decoherence rate provides a cut-off to the infrared divergences of the self-energy showing up in the Kondo regime. At low temperature, the Kondo peak in the density of states is split into two peaks pinned at the chemical potential of the two leads. The height of these peaks is controlled by $\gamma^{(4)}$. The voltage dependence of the differential conductance exhibits a zero-bias peak followed by a broad Coulomb peak at large $V$, reflecting charge fluctuations inside the dot. The low-bias differential conductance is found to be a universal function of the normalized bias voltage $V/T_K$, where $T_K$ is the Kondo temperature. The universal scaling with a single energy scale $T_K$ at low bias voltages is also observed for the renormalized decoherence rate $\gamma^{(4)}/T_K$. We discuss the effect of $\gamma^{(4)}$ on the crossover from strong to weak coupling regime when either the temperature or the bias voltage is increased.
Self-Organized Criticality in Proteins: Hydropathic Roughening Profiles of G-Protein Coupled Receptors

Proteins appear to be the most dramatic natural example of self-organized criticality (SOC), a concept that explains many otherwise apparently unlikely phenomena. Protein conformational functionality is often dominated by long-range hydro(phobic/philic) interactions which both drive protein compaction and mediate protein-protein interactions. Superfamily transmembrane GPCR are the largest family of proteins in the human genome; their amino acid sequences form the largest data base for protein-membrane interactions. While there are now structural data on the heptad transmembrane structures of representatives of several heptad families, here we show that fresh insights into global and some local chemical trends in GPCR properties can be obtained accurately from sequences alone, especially by separating the extracellular and cytoplasmic loops from transmembrane segments. The global mediation of long-range water-protein interactions occurs in conjunction with modulation of these interactions by roughened interfaces. Hydropathic roughening profiles are defined here solely in terms of amino acid sequences, and knowledge of protein coordinates is not required. Roughening profiles both for GPCR and some simpler protein families display accurate and transparent connections to protein functionality.
The Orion Fingers: Near-IR Adaptive Optics Imaging of an Explosive Protostellar Outflow

Aims. Adaptive optics images are used to test the hypothesis that the explosive BN/KL outflow from the Orion OMC1 cloud core was powered by the dynamical decay of a non-hierarchical system of massive stars. Methods. Narrow-band H2, [Fe II], and broad-band Ks obtained with the Gemini South multi-conjugate adaptive optics (AO) system GeMS and near-infrared imager GSAOI are presented. The images reach resolutions of 0.08 to 0.10", close to the 0.07" diffraction limit of the 8-meter telescope at 2.12 microns. Comparison with previous AO-assisted observations of sub-fields and other ground-based observations enable measurements of proper motions and the investigation of morphological changes in H2 and [Fe II] features with unprecedented precision. The images are compared with numerical simulations of compact, high-density clumps moving ~1000 times their own diameter through a lower density medium at Mach 1000. Results. Several sub-arcsecond H2 features and many [Fe II] 'fingertips' on the projected outskirts of the flow show proper motions of ~300 km/s. High-velocity, sub-arcsecond H2 knots ('bullets') are seen as far as 140" from their suspected ejection site. If these knots propagated through the dense Orion A cloud, their survival sets a lower bound on their densities of order 10^7 cm^-3, consistent with an origin within a few au of a massive star and accelerated by a final multi-body dynamic encounter that ejected the BN object and radio source I from OMC1 about 500 years ago. Conclusions. Over 120 high-velocity bow-shocks propagating in nearly all directions from the OMC1 cloud core provide evidence for an explosive origin for the BN/KL outflow triggered by the dynamic decay of a non-hierarchical system of massive stars. Such events may be linked to the origin of runaway, massive stars.
EVOLUTION OF THE DUST IN V4332 SAGITTARII

An eruptive nova-like event took place in 1994 in the stellar-merger candidate V4332 Sgr. Following the eruption, dust consisting of refractory silicate-rich dust grains containing a significant component of AlO bonding was formed sometime between 1998 and 2003. Observations using Spitzer between 2005 and 2009 show significant changes in the 10 μm silicate stretch feature. There is a deepening of the 10 μm silicate stretch as well as the development of a feature between about 13 and 20 μm consistent with a blend of the MgO and FeO stretching features and the O–Si–O bending mode of increasingly ordered silicate dust. Near-infrared observations show the presence of AlO and water vapor in the outflow in 2003, 2004, and 2005: the AlO has significantly decreased in spectra obtained in 2014 while the water vapor remains largely unchanged. An attempt is made to correlate these observations and understand the significance of these changes using DUSTY modeling. The observations appear consistent with the kinetically controlled condensation of highly underoxidized SiO/AlO/Fe/Mg dust grains in the outflow followed by the continuous evolution of the initial condensate due to thermal annealing and oxidation of the dust via reaction with ambient O, OH, and H2O in the expanding, cooling shell. Periodic monitoring of this dust shell over the mid-infrared spectral range could yield useful information on the evolution of underoxidized silicate condensates exposed to hot water vapor in more conventional circumstellar environments.
Statistical Model of the Early Stage of nucleus-nucleus collisions with exact strangeness conservation

The Statistical Model of the Early Stage, SMES, describes a transition between confined and deconfined phases of strongly interacting matter created in nucleus-nucleus collisions. The model was formulated in the late 1990s for central Pb+Pb collisions at the CERN SPS energies. It predicted several signals of the transition (onset of deconfinement) which were later observed by the NA49 experiment. The grand canonical ensemble was used to calculate entropy and strangeness production. This approximation is valid for reactions with mean multiplicities of particles carrying conserved charges being significantly larger than one. Recent results of NA61/SHINE on hadron production in inelastic p+p interactions suggest that the deconfinement may also take place in these reactions. However, in this case mean multiplicity of particles with non-zero strange charge is smaller than one. Thus for the modeling of p+p interactions the exact strangeness conservation has to be implemented in the SMES. This extension of the SMES is presented in the paper.