Miracle-dz/UniFAR-FTUs huggingface dataset:
What Is the Role of Nutraceutical Products in Cancer Patients? A Systematic Review of Randomized Clinical Trials

Chemotherapy represents the main pharmacological cancer treatment. Recently, positive effects emerged with the combination of anticancer therapy and nutraceutical products. The aim of this systematic review is to collect and synthesize the available scientific evidence regarding the potential effects of nutraceuticals on cancer cells. A systematic literature search of randomized clinical trials of nutraceutical products in patients with cancer published up to 15 December 2022 was conducted using three data sources: Embase, PubMed, and Web of Science. The effect of high-dose isoflavone supplements on prostate cancer resulted in stabilization or reduction of PSA concentrations in 50% of isoflavone group patients six months after treatment. High doses of vitamin D supplementation plus chemotherapy in patients with advanced or metastatic colorectal cancer showed a median PFS of 13.0 months (95% CI, 10.1–14.7 months) for 49 patients. The effect of vitamin D supplementation on markers of inflammatory level and antioxidant capacity in women with breast cancer showed a significant increase in serum vitamin D concentration (28 ± 2.6 to 39 ± 3.5; p = 0.004) after 8 weeks of treatment. In conclusion, nutraceutical supplements represent a potentially growing sector and can be utilized in medical treatment or nutrition to provide integrated medical care.
Effect of combined translation and torsion on undrained uplift capacity of plate anchors: Plastic limit analysis (PLA) solution

Uplift capacity of plate anchors has been the focus of numerous studies, because anchor plates are designed for pull‐out in normal operating conditions. However, the response of plate anchors under 6‐degrees‐of‐freedom loading caused during extreme loading conditions is poorly understood. The purpose of this study is to propose a simple yet sufficiently accurate analytical solution to investigate the behavior of plate anchor under combined in‐plane translation and torsion and to evaluate its effect on the plate uplift bearing capacity. To this end, a modified plastic limit analysis (PLA) approach is introduced and compared with limit equilibrium and simplified upper bound baseline solutions. The proposed method is verified with 3‐dimensional finite element. The variables considered in this study include plate aspect ratio, plate thickness, as well as load direction and eccentricity. Results of analytical solutions indicate the insensitivity of the “shape” of the shear‐torsion yield envelope to plate thickness. This finding facilitates the use of simplified yet reasonable yield envelope for infinitely thin plate obtained from simplified PLA approach for other plate thicknesses. The “size” of the failure envelope (controlled by pure torsional and translational capacity) could be predicted fairly accurately by PLA and limit equilibrium methods. Combination of these analytical methods offers a simple yet reasonably accurate solution to describe shear‐torsion response of anchor plate. The obtained shear‐torsion yield envelope is then fitted in the generalized 6‐degrees‐of‐freedom yield surface which describes the reducing effect of moment, torsion, and planar forces on the uplift capacity of plate.
Simulated and Observed Surface Energy Fluxes and Resulting Playa Breezes during the MATERHORN Field Campaigns

AbstractWeather Research and Forecasting (WRF) Model simulations of the autumn 2012 and spring 2013 Mountain Terrain Atmospheric Modeling and Observations Program (MATERHORN) field campaigns are validated against observations of components of the surface energy balance (SEB) collected over contrasting desert-shrub and playa land surfaces of the Great Salt Lake Desert in northwestern Utah. Over the desert shrub, a large underprediction of sensible heat flux and an overprediction of ground heat flux occurred during the autumn campaign when the model-analyzed soil moisture was considerably higher than the measured soil moisture. Simulations that incorporate in situ measurements of soil moisture into the land surface analyses and use a modified parameterization for soil thermal conductivity greatly reduce these errors over the desert shrub but exacerbate the overprediction of latent heat flux over the playa. The Noah land surface model coupled to WRF does not capture the many unusual playa land surface proces.
Disclosure of Corporate Social Responsibility on Firm Value Trough Financial Performance

This study aims to analyze corporate social responsibility disclosure to companies with financial performance as an intervening variable. This research is a quantitative research type. We conducted this study on the food and beverage sub-sector manufacturing companies listed on the Indonesia Stock Exchange involving 13 companies. The type of data is secondary in the company's annual financial report. For data analysis using descriptive statistical techniques, classical assumption test, and multiple linear regression. The results of this study indicate that CSR disclosure has a negative and insignificant effect on firm value. At the same time, CSR disclosure negatively and significantly impacts financial performance. Based on the path analysis method, corporate social responsibility disclosure cannot affect company value and financial performance. We suggest that companies consistently implement CSR even though it does not affect company value because companies still have to manage the impacts that arise.
Supply, demand and economic growth in Mexico in the period 1980–2016

Economic growth is produced by stimuli arising from supply and demand. On the supply side, growth depends on the accumulation of factors and their productivity. On the demand side, it is determined by government consumption, investment and spending and net exports. Input-output tables can be used to explain the contributions made by the growth of the components of each of the variables and to find the growth path followed by the economy. From this path it can be gauged whether the type of growth is more supply- or demand-led. This paper uses input-output tables to show that growth in Mexico has relied on more dynamic supply-side components, which is not conducive to the good performance of the economic system.
A sharp inequality involving the psi function.

The aim of this paper is to show that for a ∈ (0, 1) , the function fa (x) = ψ (x+ a) − ψ (x) − a/x is strictly completely monotonic in (0,∞) . This result improves a previous result of Qiu and Vuorinen [Math. Comp. 74(2004) 723742], who proved that f1/2 is strictly decreasing and convex in (0,∞) . As a direct consequence, a sharp inequality involving the psi function is established. 2000 Mathematics Subject Classification: 33B15, 05A16
PBR-GAN: Imitating Physically-Based Rendering With Generative Adversarial Networks

We propose a Generative Adversarial Network (GAN)-based architecture for achieving high-quality physically based rendering (PBR). Conventional PBR relies heavily on ray tracing, which is computationally expensive in complicated environments. Some recent deep learning-based methods can improve efficiency but cannot deal with illumination variation well. In this paper, we propose PBR-GAN, an end-to-end GAN-based network that solves these problems while generating natural photo-realistic images. Two encoders (the shading encoder and albedo encoder) and two decoders (the image decoder and light decoder) are introduced to achieve our target. The two encoders and the image decoder constitute the generator that learns the mapping between the generated domain and the real domain. The light decoder produces light maps that pay more attention to the highlight and shadow regions. The discriminator aims to optimize the generator by distinguishing target images from the generated ones. Three novel loss items, concentrating on domain translation, overall shading preservation, and light map estimation, are proposed to optimize the photo-realistic outputs. Furthermore, a real dataset is collected to provide realistic information for training GAN architecture. Extensive experiments indicate that PBR-GAN can preserve the illumination variation and improve the image perceptual quality.
Assessing the In Vitro Potential of Glatiramer Acetate (Copaxone®) as a Chemotherapeutic Candidate for the Treatment of Cryptococcus neoformans Infection

Cryptococcosis is a systemic mycosis affecting immunosuppressed individuals, caused by various Cryptococcus species. The current treatment utilizes a combination of antifungal drugs, but issues such as nephrotoxicity, restricted or limited availability in certain countries, and resistance limit their effectiveness. Repurposing approved drugs presents a viable strategy for developing new antifungal options. This study investigates the potential of glatiramer acetate (Copaxone®) as a chemotherapy candidate for Cryptococcus neoformans infection. Various techniques are employed to evaluate the effects of glatiramer acetate on the fungus, including microdilution, XTT analysis, electron and light microscopy, and physicochemical measurements. The results demonstrate that glatiramer acetate exhibits antifungal properties, with an IC50 of 0.470 mg/mL and a minimum inhibitory concentration (MIC) of 2.5 mg/mL. Furthermore, it promotes enhanced cell aggregation, facilitates biofilm formation, and increases the secretion of fungal polysaccharides. These findings indicate that glatiramer acetate not only shows an antifungal effect but also modulates the key virulence factor—the polysaccharide capsule. In summary, repurposing glatiramer acetate as a potential chemotherapy option offers new prospects for combating C. neoformans infection. It addresses the limitations associated with current antifungal therapies by providing an alternative treatment approach.
Dynamic Response of Bored Tunnel: Modelling and Testing

The Botlek railway tunnel is part of the cargo line “Betuweroute”. This line will run from the port of Rotterdam, The Netherlands, to Germany. The Botlek railway tunnel is a shield driven tunnel and consists of 2 tubes of 1800 m length. The tunnel was bored in typical Dutch soft soil. As part of the construction project, an extensive investigation of the dynamic response of the tunnel was carried out. The investigation is focussed on the dynamic effects from the source of the vibrations, the influence of a freight train on the tunnel to the propagation of the vibrations in the soil to the surface and piled foundations. For this research one tunnel ring is instrumented with accelerometers and strain gauges and different transducers have been installed in and on top of the soil and accelerometers have been placed in several foundation piles nearby the tunnel. Several aspects were in the experimental study investigated such as transfer function tunnel-soil and tunnel-foundation, ring-deformation, influence length of the tunnel, and induced stresses in the ground. Prior to the measurements several Finite Element Model calculations have been made to predict the vibrations in the tunnel and the transfer function tunnel-soil. The experimental results are then compared with the numerical modeling results. This paper presents some of the results of the experimental investigation and the comparison with the numerical results.
An Evaluation of Phase, Aerosol‐Cloud Interactions and Microphysical Properties of Single‐ and Multi‐Layer Clouds Over the Southern Ocean Using in Situ Observations From SOCRATES

Single‐ and multi‐layer clouds are commonly observed over the Southern Ocean in varying synoptic settings, yet few studies have characterized and contrasted their properties. This study provides a statistical analysis of the microphysical properties of single‐ and multi‐layer clouds using in‐situ observations acquired during the Southern Ocean Cloud‐Radiation Aerosol Transport Experimental Study. The relative frequencies of ice‐containing samples (i.e., mixed and ice phase) for multi‐layer clouds are 0.05–0.25 greater than for single‐layer clouds, depending on cloud layer height. In multi‐layer clouds, the lowest cloud layers have the highest ice‐containing sample frequencies, which decrease with increasing cloud layer height up to the third highest cloud layer. This suggests a prominent seeder‐feeder mechanism over the region. Ice nucleating particle (cloud condensation nuclei) concentrations are positively (negatively) correlated with ice‐containing sample frequencies in select cases. Differences in microphysical properties are observed for single‐ and multi‐layer clouds. Drop concentrations (size distributions) are greater (narrower) for single‐layer clouds compared with the lowest multi‐layer clouds. When differentiating cloud layers by top (single‐ and highest multi‐layer clouds) and non‐top layers (underlying multi‐layer clouds), total particle size distributions (including liquid and ice) are similarly broader for non‐top cloud layers. Additionally, drop concentrations in coupled environments are approximately double those in decoupled environments.
Implementation Levels of Inquiry with Blended Learning to Improve Creative Thinking Skills in the Pandemic Era

Current learning aims to improve students' skills to face 21st-century life. Creative thinking skills include 21st-century skills in innovation and technological development. This study aims to determine the improvement of students' creative thinking skills in the pandemic era using inquiry-based learning. This study uses a mixed method with an embedded design. The creative thinking skills test instrument is in the form of 14 open-ended questions developed based on the Scientific Creativity Structure Model compiled by Weiping Hu and Philip Adey. The analysis data using paired t-test. The results of statistical tests using paired t-tests showed a significant value of 0.000. Based on the decision-making criteria, if the significance value is less than 0.005, then Ho is rejected. The result can be interpreted as a significant difference between the pre-and post-test results. In addition, the increase in pretest-posttest scores was tested using n-gain and obtained a score of 0.55 in the medium category. Therefore, implementing levels of inquiry with blended learning on the light wave concept can improve the creative thinking skills in the medium category.
The influence of motivation and habit on acceptance of elementary school students using Google Classroom

This study aimed to prove the factors that influence elementary school students’ interest in using the Google Classroom platform. This study also used a technology acceptance model (TAM) theory approach by adding external variables, namely motivation and habit, to the study. The survey method was conducted to collect data from 209 elementary school students. We analyzed the data using the structural equation modeling (SEM) PLS 3.0 application. The study’s results showed that one hypothesis was rejected: Motivation had no significant effect on perceived usefulness. In contrast, the other seven hypotheses had a significant positive effect. Research suggested that the habit factor fits the theoretical approach of the TAM model.
Risk factors for multiple sclerosis in the context of Epstein-Barr virus infection

Compelling evidence indicates that Epstein Barr virus (EBV) infection is a prerequisite for multiple sclerosis (MS). The disease may arise from a complex interplay between latent EBV infection, genetic predisposition, and various environmental and lifestyle factors that negatively affect immune control of the infection. Evidence of gene-environment interactions and epigenetic modifications triggered by environmental factors in genetically susceptible individuals supports this view. This review gives a short introduction to EBV and host immunity and discusses evidence indicating EBV as a prerequisite for MS. The role of genetic and environmental risk factors, and their interactions, in MS pathogenesis is reviewed and put in the context of EBV infection. Finally, possible preventive measures are discussed based on the findings presented.
Moduli spaces of parabolic twisted generalized Higgs bundles

In this thesis we study moduli spaces of decorated parabolic principal G-bundles on a compact Riemann surface X. In [Sch08] Alexander Schmitt constructed the moduli space of affine generalized Higgs bundles consisting of a principal G-bundle P on X and a global section into an associated vector bundle as a GIT-quotient. Affine Higgs bundles are generalizations of several well-studied objects, such as G-Higgs bundles, Bradlow pairs or quiver representations. In this work we generalize this GIT-construction of the moduli space of affine Higgs bundles to the case of affine parabolic Higgs bundles. A parabolic structure on P over a fixed finite subset S of punctures of the compact Riemann Surface X is given by reductions over S to parabolic subgroups of G. Our main result shows the existence of the resulting moduli space of decorated parabolic bundles as a quasi-projective scheme. The moduli space of parabolic G-Higgs bundles (see [Sim94]) is obtained from our construction by slight modifications of the semistability concept. Other important applications include the construction of a (generalized) projective Hitchin morphism into an affine scheme as well as an extension of the results of Nikolai Beck [Be14] on moduli spaces of pointwisely decorated principal bundles.
Structural health monitoring of cylindrical bodies under impulsive hydrodynamic loading by distributed FBG strain measurements

Various mechanical, ocean, aerospace and civil engineering problems involve solid bodies impacting the water surface and often result in complex coupled dynamics, characterized by impulsive loading conditions, high amplitude vibrations and large local deformations. Monitoring in such problems for purposes such as remaining fatigue life estimation and real time damage detection is a technical and scientific challenge of primary concern in this context. Open issues include the need for developing distributed sensing systems able to operate at very high acquisition frequencies, to be utilized to study rapidly varying strain fields, with high resolution and very low noise, while scientific challenges mostly relate to the definition of appropriate signal processing and modeling tools enabling the extraction of useful information from distributed sensing signals. Building on previous work by some of the authors, we propose an enhanced method for real time deformed shape reconstruction using distributed FBG strain measurements in curved bodies subjected to impulsive loading and we establish a new framework for applying this method for structural health monitoring purposes, as the main focus of the work. Experiments are carried out on a cylinder impacting the water at various speeds, proving improved performance in displacement reconstruction of the enhanced method compared to its previous version. A numerical study is then carried out considering the same physical problem with different delamination damages affecting the body. The potential for detecting, localizing and quantifying this damage using the reconstruction algorithm is thoroughly investigated. Overall, the results presented in the paper show the potential of distributed FBG strain measurements for real time structural health monitoring of curved bodies under impulsive hydrodynamic loading, defining damage sensitive features in terms of strain or displacement reconstruction errors at selected locations along the structure.
Influence of education and the media on the awareness of climate change (Influencia de la educación y la comunicación en la concienciación sobre el cambio climático)

ABSTRACT Education and the media are two factors that affect a person’s level of awareness of the climate. This study was conducted around these two axes with surveys of 565 secondary, baccalaureate, vocational and university students with the goal of ascertaining whether there is a different degree of awareness according to educational level and to what extent education and the media have contributed to the different sensibilities of these students, who are the future of society. To do so, stratified sampling and principal components, cluster and linear correlation analyses were conducted. The main results include that the group of students with the highest level of awareness and activity regarding climate change are university women, while the media have a heavier influence on youths than education, which should therefore reinforce its role through strategies like environmental educommunication.
THE INTEGRATION OF CULTURAL ELEMENTS IN THE ENGLISH LANGUAGE CLASSROOMS: A CASE STUDY OF SELECTED ORANG ASLI SCHOOLS IN PAHANG, MALAYSIA

Background and Purpose: This study examined the challenges faced by the Orang Asli students from the Jah Hut tribe and their reactions towards the integration of their cultural elements in learning the English language at two Orang Asli schools in Temerloh, Pahang, Malaysia. It also sought to investigate students’ and teachers’ motivation in learning and teaching the subject. Methodology: This critical qualitative inquiry employed a case study approach employing semi-structured interviews and non-participant classroom observations. A total of 14 participants were selected through purposive sampling technique, which consisted of ten Orang Asli students, three Orang Asli teachers, and one Malay teacher from two Orang Asli’s schools in Temerloh district. Findings: The findings indicated that integrating the Orang Asli’s own culture into the English lessons had captivated their interest immensely. The most motivating and stimulating lessons were centred around cultural celebrations, the use of the native language, cooking the Orang Asli delicacies, and parading and explaining their outfits and costumes. Teachers responded to the importance of Culturally Responsive Teaching strategies’ acceptance and use in the classrooms regardless of the composition of the students. Similarly, they felt that the knowledge of understanding the cultures of others is critical as it allows one to understand the struggles, and slowly develop a sense of appreciation towards differences. Contribution: The study highlights pertinent information regarding the issue of a ‘one size fits all curriculum’, especially in the teaching of the English language with the diversity of people in Malaysia. It also provides suggestions on classroom teaching strategies for multicultural classrooms. It also adds input to the existing literature on the integration of cultural elements in the teaching of the English language to the Orang Asli students. Keywords: Integration, culturally responsive teaching, Orang Asli, Jah Hut, ESL classrooms, cultural elements, indigenous pedagogy, English language curriculum. Cite as: Idrus, F. , Hussin, M. E, & Gulca, M. (2023). The integration of cultural elements in the English language classrooms: A case study of the Orang Asli settlement in Pahang, Malaysia. Journal of Nusantara Studies, 8(1), 26-45. http://dx.doi. org/10.24200/jonus.vol8iss1pp26-45
Unstructured discretisation of a non-local transition model for turbomachinery flows

The description of transitional flows by means of RANS equations is sometimes based on non-local approaches which require the computation of some boundary layer properties. In this work a non-local Laminar Kinetic Energy model is used to predict transitional and separated flows. Usually the non-local term of this model is evaluated along the grid lines of a structured mesh. An alternative approach, which does not rely on grid lines, is introduced in the present work. This new approach allows the use of fully unstructured meshes. Furthermore, it reduces the grid-dependence of the predicted results. The approach is employed to study the transitional flows in the T106c turbine cascade and around a NACA0021 airfoil by means of a discontinuous Galerkin method. The local nature of the discontinuous Galerkin reconstruction is exploited to implement an adaptive algorithm which automatically refines the mesh in the most significant regions.