Miracle-dz/UniFAR-FTUs huggingface dataset:
The Structure of 2,6-Di-tert-butylphenol–Argon by Rotational Spectroscopy

The molecular structure of a van der Waals-bonded complex involving 2,6-di-tert-butylphenol and a single argon atom has been determined through rotational spectroscopy. The experimentally derived structural parameters were compared to the outcomes of quantum chemical calculations that can accurately account for dispersive interactions in the cluster. The findings revealed a π-bound configuration for the complex, with the argon atom engaging the aromatic ring. The microwave spectrum reveals both fine and hyperfine tunneling components. The main spectral doubling is evident as two distinct clusters of lines, with an approximate separation of 179 MHz, attributed to the torsional motion associated with the hydroxyl group. Additionally, each component of this doublet further splits into three components, each with separations measuring less than 1 MHz. Investigation into intramolecular dynamics using a one-dimensional flexible model suggests that the main tunneling phenomenon originates from equivalent positions of the hydroxyl group. A double-minimum potential function with a barrier of 1000 (100) cm−1 effectively describes this extensive amplitude motion. However, the three-fold fine structure, potentially linked to internal motions within the tert-butyl group, requires additional scrutiny for a comprehensive understanding.
DPred_3S: identifying dihydrouridine (D) modification on three species epitranscriptome based on multiple sequence-derived features

Introduction: Dihydrouridine (D) is a conserved modification of tRNA among all three life domains. D modification enhances the flexibility of a single nucleotide base in the spatial structure and is disease- and evolution-associated. Recent studies have also suggested the presence of dihydrouridine on mRNA. Methods: To identify D in epitranscriptome, we provided a prediction framework named “DPred_3S” based on the machine learning approach for three species D epitranscriptome, which used epitranscriptome sequencing data as training data for the first time. Results: The optimal features were evaluated by the F-score and integration of different features; our model achieved area under the receiver operating characteristic curve (AUROC) scores 0.955, 0.946, and 0.905 for Saccharomyces cerevisiae, Escherichia coli, and Schizosaccharomyces pombe, respectively. The performances of different machine learning algorithms were also compared in this study. Discussion: The high performances of our model suggest the D sites can be distinguished based on their surrounding sequence, but the lower performance of cross-species prediction may be limited by technique preferences.
Digital Transformation Model and the Role of HR in Indonesian MSMEs

This study looks into how important human resources (HR) are to Indonesia's Micro, Small, and Medium-sized Enterprises (MSMEs) as they embark on a digital transformation. The study uses a quantitative method with a sample of 568 participants and focuses on the impact of staff skills, digital strategy, employee retention, and satisfaction. The findings indicate that there are complex interactions at play: employee skills show a negative correlation with the speed at which digital transformation is occurring, but employee retention, satisfaction, and digital strategy have a beneficial impact on both digital transformation and competitiveness in the global market. The study gives HR professionals useful insights and draws attention to the complex factors that will determine MSMEs' digital future. This study adds to the growing body of knowledge on HR and digital transformation by offering insightful recommendations for businesses attempting to navigate the challenging terrain of the Fourth Industrial Revolution.
Cattle grazing influence on a mountain riparian zone.

A combination of management and physical topographic constraints caused cattle to concentrate on the riparian zone early in the grazing season in 1977 and 1978. A large percentage of cattle days and vegetation utilization on the riparfan zone occurred in the first 4 weeks of the grazing period. Utilization on herbaceous vegetation was 76 and 72% in 1977 and 1978, respectively. Impact of grazing on the most prevalent species, Kentucky bluegrass was minimal. Shrub use increased with increased maturity of herbaceous vegetation. Utilization of major shrubs was not excessive in either year, and very likely had no long-term effects on either the abundance or vigor of the shrubs. Riparian zones are those areas associated with streams, lakes, and wet areas where plant communities are predominately influenced by their association with water. They are key areas for a wide variety of uses. Fisheries and wildlife biologists have suggested mountain riparian zones are critical habitats in maintaining viable populations of fish, birds, small and big game animals (Ames 1977, Hubbard 1977). These areas are extremely important in providing forage and water for domestic animals (Phillips 1965, Cook 1966). Watershed specialists have indicated that the riparian zone plays an integral role in water quantity and quality (Horton and Campbell 1977). The U.S. government land management agencies, committed by law to manage for multiple use, have identified riparian zones as critical management areas.
On growth and form of etched fission tracks in apatite: A kinetic approach

Abstract We discuss differences between the bulk etch rate (νB) and an alternative radial etch rate (νR) model for fission-track etching in apatite. A skeletal νR-model, based on the inferred orientations of the νR minima and maxima, accounts for the main geometrical features of etched fission tracks, including the track-surface intersections, track channels and their terminations, and the outlines of confined tracks. It unifies the diverse appearances of etched tracks as variations of a basic plan, governed by the orientation of the etched surface and that of the track. The νR-model also embeds fission-track etching in the mainstream theories of crystal growth and dissolution. However, in contrast to the νB-model, the νR-model does not provide bottom-up criteria for discriminating between tracks that are counted by an observer or a computer program and those that are not. Moreover, abandoning the νB-model implies that basic assumptions of fission-track dating must be reconsidered, in particular that track counting efficiencies depend only on a critical dip angle, and are thus independent of the track registration geometry and the length distribution.
Performance of European and American Societies of Gastrointestinal Endoscopy Guidelines for Prediction of Choledocholithiasis in Patients with Acute Biliary Pancreatitis

Background and Objectives: Up to one-third of patients with acute biliary pancreatitis also present with choledocholithiasis. Guidelines from the European Society of Gastrointestinal Endoscopy (ESGE) and the American Society for Gastrointestinal Endoscopy (ASGE) for investigating suspected choledocholithiasis suggest endoscopic retrograde cholangiopancreatography in patients with high-likelihood (ESGE)/high-probability (ASGE) predictors and endoscopic ultrasound in those with intermediate-likelihood (ESGE)/intermediate-probability (ASGE) predictors. Although both guidelines are similar, they are not identical. Furthermore, these algorithms were mainly developed from cohorts of patients without pancreatitis and are therefore poorly validated in a subset of patients with acute pancreatitis. We aimed to assess the performance of the ESGE and ASGE algorithms for the prediction of choledocholithiasis in patients with acute biliary pancreatitis. Materials and Methods: This was a retrospective analysis of 86 consecutive patients admitted to a tertiary referral centre in the year 2020 due to acute biliary pancreatitis. Results: Choledocholithiasis was confirmed in 29/86 (33.7%) of patients (13 with endoscopic retrograde cholangiopancreatography and 16 with endoscopic ultrasound). All 10/10 (100%) ESGE high-likelihood and 14/19 (73.7%) ASGE high-probability patients had choledocholithiasis. Only 19/71 (26.8%) patients with ESGE intermediate likelihood and 15/67 (22.4%) with ASGE intermediate probability had choledocholithiasis. Only 8/13 (61.5%) patients with the ASGE high-probability predictor of dilated common bile duct plus bilirubin > 68.4 µmol/mL had choledocholithiasis. Since this predictor is not considered high likelihood by ESGE, this resulted in a superior specificity of the European compared to the American guideline (100% vs. 91.2%). Following the American instead of the European guidelines would have resulted in five unnecessary endoscopic retrograde cholangiopancreatographies and five unnecessary endoscopic ultrasound examinations. Conclusions: This retrospective analysis suggests that the European guidelines may perform better than the American guidelines at predicting choledocholithiasis in the setting of acute pancreatitis. This was because dilated common bile duct plus bilirubin > 68.4 µmol/mL was not a reliable predictor for persistent bile duct stones.
Atypical Burials from the Early Middle Ages in the Territory of Western Slovakia

The change in the burial rite in the early Middle ages brought new problems in the interpretation of burials. Within the regular graves, with individuals placed in stretched supine position with the head towards the west, occurred also those who defy this rule. They are mainly the graves found outside the cemeteries (isolated graves, graves at settle - ment, individuals laid in settlement features) and graves of individuals buried at cemeteries but in atypical positions (individuals in prone, lateral, or other rare positions) or orientation (north-southern directions of a grave pit or with the head laid towards the east), eventually the graves with identified posterior interventions. These atypical graves gain the attention of european scientists, who try to interpret them, in the last few years. The paper concentrates on these graves from the territory of western Slovakia from the period of the 9 th to 12 th c. and tries to contribute to the understanding of this problem.
Common Buzzard (Buteo buteo) population during winter season in North-Eastern Romania: the influences of density, habitat selection, and weather

Common Buzzards (Buteo buteo) in Eastern Europe are partial migrants, and their numbers in a specific area fluctuate during the winter season. In the cold season of 2010-2011 we carried out 15 car-transect counts, each 40 km in length, during four months (November-February) to study the wintering population of the Common Buzzard in North-Eastern Romania. The counts revealed a density of 0.334-0.539 individuals/ km for the winter season. Birds were non-randomly distributed across habitat types: agricultural land and especially areas with natural perches (trees or bushes) were used disproportionately commonly. The density of Common Buzzard varied during the four months, and was influenced by temperature. The numbers of Common Buzzards peaked at transects with complete snow cover and during periods of lower-than-average temperature.
Benefits of Cross-Pollination in Vegetable Soybean Edamame

Dependence on cross-pollination varies widely among wild and cultivated plant species. Even among crops that are less dependent on outcrossing, such as soybean (Glycine max L.), cross-pollination can improve fruit quality and commercial value. There is a growing body of literature regarding the role of insect pollination in soybean; however, there is a knowledge gap on the intersection between the reproductive system of soybean and its pollination ecology. To address this gap, we first sought to characterize the reproductive system of vegetable soybean (edamame) in terms of benefits and reliance on outcrossing using three traditional experimental pollination scenarios in field conditions: open pollination, automatic selfing (pollinator-exclusion), and hand cross-pollination (controlled crossing). We also tested whether proximity to floral supplements planted on one edge of the field affected its reproductive outputs, and surveyed the floral visitors of the crop. Overall, we found a significant increase in fruit weight among open-pollinated plants compared to those in the automatic selfing treatment, with this effect accentuated with proximity to the flower strip. Despite open pollinated flowers having 30% higher flower abortions rates compared to automatic selfing, the number of developed seeds per fruit was similar among these treatments, with open-pollination having a greater proportion of commercial grade-A fruits. Additionally, grade-A fruits in open-pollination and hand cross-pollination treatments were similar in weight, both of which were significantly heavier than those in the automatic selfing treatment. Although edamame can automatically self, our results suggest that reproductive outputs including fruit weight and number of commercial grade-A fruits are positively affected by cross-pollination and proximity to floral supplements.
Wetland Hydrodynamics Using Interferometric Synthetic Aperture Radar, Remote Sensing, and Modeling

ii DEDICATION . iv ACKNOWLEDGMENTS . v VITA. vii TABLE OF CONTENTS . x LIST OF TABLES . xiii LIST OF FIGURES . xiv Chapter 1: Introduction . 1 1.1 Statement of Problem . 1 1.2 Background and Relevance to Previous Work . 3 1.2. 1 Interferometric SAR Observations in Wetlands . 3 1.2. 2 Remote Sensing for Flood Inundation Mapping . 8 1.2. 3 Hydrodynamic Modeling . 10 Chapter 2: Repeat-pass Multi-temporal Interferometric SAR Coherence Variations with Amazon Floodplain and Lake Habitats . 14 2.
Fatty Acid Metabolism-Related lncRNAs are Potential Biomarkers for Predicting Prognoses and Immune Responses in Patients with Skin Cutaneous Melanoma

Introduction Skin cutaneous melanoma is becoming more dangerous since it has a poor prognosis and is resistant to treatment. Previous research has shown that lncRNAs and fatty acid metabolism are essential for numerous biological activities. There are no studies on the relationship between fatty acid metabolism-Related lncRNAs and skin cutaneous melanoma. Methods and Results In order to better understand the prognosis and survival of SKCM patients, we investigated the significance of lncRNAs related to fatty acid metabolism. In this work, we looked at the fatty acid metabolism genes and lncRNAs expression patterns. On the basis of lncRNAs associated with fatty acid metabolism, a nomogram and a prognosis prediction model were created. Based on the profile of lncRNAs associated with fatty acid metabolism, functional and pharmacological sensitivity investigations were also carried out. We also looked at the connection between immunotherapy and the immune response. The findings demonstrated that a risk score model based on 11 essential lncRNAs for fatty acid metabolism may discriminate between the clinical condition of SKCM and more accurately predict prognosis and survival. We conducted quantitative reverse transcription polymerase-chain reaction (RT-PCR) to verify the model. Conclusion These important lncRNAs further showed a strong association with the tumor immune system, and these important lncRNAs also showed a connection between SKCM and chemotherapeutic treatment sensitivity. Our research strives to provide fresh viewpoints and innovative approaches to the treatment and administration of SKCM.
Prediction of Plastic Shrinkage Cracking of Supplementary Cementitious Material-Modified Shotcrete Using Rheological and Mechanical Indicators

Plastic shrinkage cracking is a complex and multifaceted process that occurs in the period between placement and the final setting. During this period, the mixture is viscoplastic in nature and therefore possesses rheological properties. The investigation of the relationship between rheological behavior and its propensity to undergo cracking during the plastic phase presents an intriguing subject of study. However, many factors influence plastic cracking, and the corresponding interaction of its effects is complex in nature. This study aimed to evaluate the impact of rheological and physicomechanical properties on the occurrence of plastic cracking in high-performance shotcrete containing various supplementary cementitious materials. To achieve this, plastic cracking was evaluated employing the ASTM C 1579 standard and a smart crack viewer FCV-30, and the rheological parameters were controlled using an ICAR rheometer. In addition, a study was conducted to assess the strength development and fresh properties. Further, a relationship was established via statistical evaluation, and the best predicting models were selected. According to the study results, it can be concluded that high-yield stress and low plastic viscosity for colloidal silica mixtures are indicators of plastic cracking resistance owing to improved fresh microstructure and accelerated hydration reaction. However, earlier strength development and the presence of a water-reducing admixture allowed mixtures containing silica fume to achieve crack reduction. A higher indicator of yield stress is an indicator of the capillary pressure development of these mixtures. In addition, a series containing ultrafine fly ash (having high flow resistance and torque viscosity) exhibited a risk of early capillary pressure build-up and a decrease in strength characteristics, which could be stabilized with the addition of colloidal silica. Consequently, the mixture containing both silica fume and colloidal silica exhibited the best performance. Thus, the results indicated that rheological characteristics, compressive strength, and water-reducer content can be used to control the plastic shrinkage cracking of shotcrete.
Reflections on the Application and Validation of Technology in Language Testing

ABSTRACT This paper highlights as issues of concern the rapid changes in technology and the tendency to report on partial validation efforts where the work is not identified as forming part of a larger validation project. With close human supervision emerging technologies can have a significant and positive impact on language testing. While technology seems to be constantly changing and improving, there is still a lot to learn in the approaches these papers take in identifying aspects of the constructs of interest amenable to operationalization and measurement through technology. In terms of validation, the paper suggests a number of important things to consider. These include presenting assessment arguments in a form that meets the needs of the stakeholder groups most clearly affected by the claims being made; working towards an interactive communication-based argument approach, ideally involving validators who are independent of the developer; and ensuring that any “partial” validation is explicitly linked to a broader argument. The paper ends by predicting that technology will see the practice of language testing changing radically from where it is today and while fairness, justice and validation will always be primary concerns, the challenges associated with establishing evidence of these will only increase.
Integration of a Low Gas-Saturated Zone in Creating a 3D Model of the Medvezhye Field

3D geological modeling is an integral part of reserves estimation and project documentation for the development of gas and oil fields. The developed 3D geological model of the Cenomanian productive complex including the low gas-saturated zone of the Medvezhye field represents a combination of data from the drilling of 350 wells, the structural features of the reservoir, permeability properties determined on cores, seismic surveys, and the results of geophysical well surveys. Based on examining the available well logs recorded in the Medvezhye field wells, the low gas-saturated zone is integrated into the construction of the 3D geological model of the Medvezhye field of the Cenomanian productive complex. A total of three models are constructed, and a 400*400*0.4 m grid is recommended for further hydrodynamic modeling. A comparison of the three grids suggests that a more detailed model delivers more thorough results, however, heavy models cannot be applied to hydrodynamic modeling. Resource estimations do not differ across the three grids significantly.
Appraisal of Novel Oncological Therapies by the Scottish Medicines Consortium and the National Institute for Health and Care Excellence: A Comparative Study of Six Years of Data

Background and aims Pharmacoeconomic assessment of novel oncological therapies is an increasingly important factor in determining patient access to therapies. Organisations such as the National Institute for Health and Care Excellence (NICE) in England and the Scottish Medicines Consortium (SMC) in Scotland assess medications for their cost-effectiveness through health technology assessments (HTA) and provide guidance on whether the public health service should fund a therapy. We assessed six years of data to determine if there were any differences in timescales and decisions between NICE and SMC for new oncological therapies. Methods and results Time (days) from marketing authorisation (MA) to publication of final HTA guidance was calculated for single technology appraisals published by NICE and SMC between January 1, 2017, and December 31, 2022, for oncological therapies. We assessed 161 HTAs by NICE and 148 HTAs by SMC published in the study period. The median time from MA to publication of HTA guidance was 291 days (IQR 222-406) for SMC and 257 days (IQR 167-448) for NICE (p=0.054). For solid organ cancer therapies, NICE was significantly faster in publishing guidance, with a median of 231.5 days (IQR 148-392.25), compared to SMC, which took 273 days (IQR 202-378) (p=0.039). Overall recommendation of technologies was similar between the SMC and NICE (90.5% and 89.4%, respectively), with discordance in a minority of cases (12.6%). Conclusions Recommendation rates for single HTAs are similar between NICE and SMC for oncological therapies with discordance in a minority of cases. The time from MA to publication of HTA guidance was similar overall, but NICE was faster in publishing HTA guidance for solid organ cancer indications. Differences in methodology and process between the two organisations, in particular the presence of the Cancer Drugs Fund in England, may explain this difference in publication times.
Deficiency of Acute-Phase Serum Amyloid A Exacerbates Sepsis-Induced Mortality and Lung Injury in Mice

Serum amyloid A (SAA) is a family of proteins, the plasma levels of which may increase >1000-fold in acute inflammatory states. We investigated the role of SAA in sepsis using mice deficient in all three acute-phase SAA isoforms (SAA-TKO). SAA deficiency significantly increased mortality rates in the three experimental sepsis mouse models: cecal ligation and puncture (CLP), cecal slurry (CS) injection, and lipopolysaccharide (LPS) treatments. SAA-TKO mice had exacerbated lung pathology compared to wild-type (WT) mice after CLP. A bulk RNA sequencing performed on lung tissues excised 24 h after CLP indicated significant enrichment in the expression of genes associated with chemokine production, chemokine and cytokine-mediated signaling, neutrophil chemotaxis, and neutrophil migration in SAA-TKO compared to WT mice. Consistently, myeloperoxidase activity and neutrophil counts were significantly increased in the lungs of septic SAA-TKO mice compared to WT mice. The in vitro treatment of HL-60, neutrophil-like cells, with SAA or SAA bound to a high-density lipoprotein (SAA-HDL), significantly decreased cellular transmigration through laminin-coated membranes compared to untreated cells. Thus, SAA potentially prevents neutrophil transmigration into injured lungs, thus reducing exacerbated tissue injury and mortality. In conclusion, we demonstrate for the first time that endogenous SAA plays a protective role in sepsis, including ameliorating lung injury.