Miracle-dz/UniFAR-FTUs huggingface dataset:
Separating the Signal from the Noise: How Psychiatric Diagnoses Can Help Discern Food Addiction from Dietary Restraint

Converging evidence from both animal and human studies have implicated hedonic eating as a driver of both binge eating and obesity. The construct of food addiction has been used to capture pathological eating across clinical and non-clinical populations. There is an ongoing debate regarding the value of a food addiction “diagnosis” among those with eating disorders such as anorexia nervosa binge/purge-type, bulimia nervosa, and binge eating disorder. Much of the food addiction research in eating disorder populations has failed to account for dietary restraint, which can increase addiction-like eating behaviors and may even lead to false positives. Some have argued that the concept of food addiction does more harm than good by encouraging restrictive approaches to eating. Others have shown that a better understanding of the food addiction model can reduce stigma associated with obesity. What is lacking in the literature is a description of a more comprehensive approach to the assessment of food addiction. This should include consideration of dietary restraint, and the presence of symptoms of other psychiatric disorders (substance use, posttraumatic stress, depressive, anxiety, attention deficit hyperactivity) to guide treatments including nutrition interventions. The purpose of this review is to help clinicians identify the symptoms of food addiction (true positives, or “the signal”) from the more classic eating pathology (true negatives, or “restraint”) that can potentially elevate food addiction scores (false positives, or “the noise”). Three clinical vignettes are presented, designed to aid with the assessment process, case conceptualization, and treatment strategies. The review summarizes logical steps that clinicians can take to contextualize elevated food addiction scores, even when the use of validated research instruments is not practical.
Incongruent Audiovisual Inducer Information and Fission/Fusion Illusions

In research studies on how people perceive simultaneously presented audiovisual information, researchers have often shown that the number of visual flashes participants perceive on a computer screen can be altered by varying the number of accompanying auditory, visual, or combined audiovisual cues or inducers. In the present study, we examined the effects of number-incongruent audiovisual inducer stimuli on the participants’ perceived number of target flashes. We instructed 16 participants (eight males and eight females; Mage = 21.56; SDage = 1.93) to report their perceived number of target flashes while ignoring the visual and auditory inducers. Across 18 different experimental conditions, we presented one or two target flashes in association with varied numbers (0, 1, 2) of auditory and visual inducer stimuli. In the condition with one target flash paired with one visual and two auditory inducers, the number of visual inducers (i.e., one) had a greater influence on the number of perceived target flashes than did the number of auditory inducers (i.e., two). Under all other number incongruent audiovisual inducer conditions, the participants’ perceived number of target flashes was influenced more by the number of auditory than the number of visual inducers. We discuss these findings in the context of perceptual grouping and perceptual temporal uncertainty.
The self-identity of ecological units

Ascertaining whether an ecosystem, a community or any other ecological unit has completely changed. whether it has been destroyed or whether it remains the same is a common task for ecologists. At the heart of this task is the question of what constitutes the identity of a unit through time. which we call self-identity. The determination of self-identity requires that we know what the essence of an ecological unit is. This is highly dependent on the definition and specification of the ecological unit of interest, which in turn, depends upon the question(s) being asked. We develop a framework to provide unambiguous definitions of ecological units. The components of this framework are different criteria describing the spatial or process-based boundaries of a unit, the degree of required internal relationship and the level of abstraction t an ecological unit is specified. These criteria can be represented in a three-dimensional graphical model which locates the definitions of ecological units within a conceptual volume. We describe the application of the model for the assessment of the self-identity of ecological units through time. The specification of ecological units and the possibility of assessing the self-identity of ecological objects are also dependent upon the specific ecological theories applied (and upon issues that reside outside the realm of pure ecological science). The universe of meaningful questions and of ecological units is constrained by both societal and scientific interests. We argue that a precise specification of ecological units is necessary for advancing both ecological understanding and its application.
Treatment of coronavirus disease 2019

Purpose of review Coronavirus disease 2019 (COVID-19) is a highly contagious and potentially lethal pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). No specific antiviral treatment is currently available. The purpose of this review is to highlight the main repurposed drug treatments with in-vitro or in-vivo efficacy against the SARS-CoV-2. Recent findings Recent clinical trials suggested remdesivir, IFN-β-1b and favipiravir have potential clinical and/or virological benefits on patients with COVID-19. Short course of stress dose of corticosteroids might be used as adjunctive treatment to patients who are late presenters with cytokine storm. Convalescent plasma from recovered COVID-19 patients with high neutralizing antibody might also be beneficial in the treatment of severe disease. Summary Early effective antiviral therapy in COVID-19 patients will suppress the SARS-CoV-2 viral load. Adjunctive therapy with corticosteroid and convalescent plasma might further ameliorate the cytokine response. Further randomized clinical trials of combination therapy are needed.
The Comparative Effects of Pruning by Burning or Clipping on Lowbush Blueberries in North-Eastern Ontario

The lowbush blueberries, especially Vaccinium angustifolium Ait. and its varieties and forms (Smith 1969), are widespread and abundant in most regions of north-eastern Ontario. Natural stands of these indigenous species may offer considerable potential as a commercial fruit crop in this region (Smith, Hilton & Evans 1968). Of the cultural practices used to improve natural stands of these plants pruning by burning is probably the most common. Burning on a 2 or 3 year basis to increase shoot growth and fruit production is the usual practice in regions presently producing lowbush blueberry fruit on a commercial scale (Eaton & White 1960). Also, burning evidently offers some advantage by partially removing competitive growth of other species and controlling certain insect pests but these effects are poorly documented. Black (1963) suggested that the short and long-term ecological effects of burning have not received sufficient investigation to justify the practice. The lack of knowledge of the effects of burning is particularly true for north-eastern Ontario which differs in climate and soil from the maritime regions of North America and Great Britain where the practice of burning has been studied (Allen 1964; Black 1963; Chapman 1967; Eaton & White 1960; Robertson & Davies 1965). Boultbee (1956) has reported increased blueberry foliage cover and fruit production as an immediate effect of burning at a northern Ontario location but accompanying soil changes were not considered. This paper reports on the effects on lowbush blueberries and associated species of pruning by two methods of burning and by mechanical clipping, on three dates in the growing season at a north-eastern Ontario location. Significant soil changes recorded during the study are included in this report. The paper forms part of a larger scale ecological study of the effects of burning and an evaluation of the potential of lowbush blueberries as a fruit crop in northern Ontario.
Experimental Velogenic Newcastle Disease Can Be Very Severe and Viscerotropic in Chickens but Moderate and Neurotropic in Guinea Fowls

Information about the pathogenesis of Newcastle disease (ND) is still limited in many avian species including some poultry birds. Four weeks old cockerels and guinea fowls were inoculated with a local Nigerian velogenic ND (VND) Virus (VNDV) strain, Kudu-113, intramuscularly. The main clinical signs in chickens were severe depression and diarrhoea while the guinea fowls showed mainly leg paralysis. Weight loss was significant in the infected birds in both species from days 3-21 post inoculation (PI). The total mortalities in the guinea fowls and chickens were 22.2 and 94.6%, respectively. The guinea fowls showed no proventricular haemorrhage, intestinal ulcers, haemorrhages and swelling of the caecal tonsil which were all prominent in the cockerels. Gross congestion of the brain was observed in the guinea fowls only. But lesions in the lymphoid organs and microscopic changes in the brain were similar in both species. The antibody response to the viral inoculation was higher in the chickens than the guinea fowls. The above observations confirm experimentally that chickens are more susceptible to VND than guinea fowls. Furthermore, the Kudu-113 infection was viscerotropic in chickens but neurotropic in guinea fowls.
Upper and Lower Respiratory Signs and Symptoms in Workers Occupationally Exposed to Flour Dust

A group of 142 bakers was studied in order to investigate the relationship between higher/lower respiratory signs/symptoms and inflammation biomarkers and occupational exposure to flour dust. A complete upper and lower respiratory tract evaluation was performed. Seven percent of bakers complained of lower respiratory symptoms, while 22% of them complained of upper respiratory symptoms. Fifty five percent of the bakers were allergic, and 37.1% showed sensitization to occupational allergens. Abnormal spirometries were found in 15% of bakers, while fractional exhaled nitric oxide (FeNO) was above the normal reference in 24.5% of them. Moreover, 23.8% of bakers were found to be hyposmic. Population mean peak nasal inspiratory flow (PNIF) was in the normal range even if almost all the workers suffered from neutrophilic rhinitis at nasal cytology with the number of nasal neutrophils increasing with the increase of the duration of exposure to flour dust (p = 0.03). PNIF and FEV1 (forced expiratory volume in the 1st second) showed a positive correlation (p = 0.03; r = 0.19). The Tiffeneau index decreased with the increase of dust (p = 0.017). A similar result was obtained once we divided our population into smokers and non-smokers (p = 0.021). Long-term exposure to bakery dusts can lead to a status of minimal nasal inflammation and allergy.
Purkinje cell neurotransmission patterns cerebellar basket cells into zonal modules defined by distinct pinceau sizes

Ramón y Cajal proclaimed the neuron doctrine based on circuit features he exemplified using cerebellar basket cell projections. Basket cells form dense inhibitory plexuses that wrap Purkinje cell somata and terminate as pinceaux at the initial segment of axons. Here, we demonstrate that HCN1, Kv1.1, PSD95 and GAD67 unexpectedly mark patterns of basket cell pinceaux that map onto Purkinje cell functional zones. Using cell-specific genetic tracing with an Ascl1CreERT2 mouse conditional allele, we reveal that basket cell zones comprise different sizes of pinceaux. We tested whether Purkinje cells instruct the assembly of inhibitory projections into zones, as they do for excitatory afferents. Genetically silencing Purkinje cell neurotransmission blocks the formation of sharp Purkinje cell zones and disrupts excitatory axon patterning. The distribution of pinceaux into size-specific zones is eliminated without Purkinje cell GABAergic output. Our data uncover the cellular and molecular diversity of a foundational synapse that revolutionized neuroscience.
Acquisition Risk Factors of the SCCmec IX-Methicillin-Resistant Staphylococcus aureus in Swine Production Personnel in Chiang Mai and Lamphun Provinces, Thailand

Methicillin-resistant Staphylococcus aureus (MRSA) harboring the type-IX staphylococcal cassette chromosome mec (SCCmec) has been found in pigs and humans in Northern Thailand. However, knowledge of the prevalence and acquisition risk factors of this MRSA strain among swine production personnel (SPP) are needed. The nasal swab samples and data were collected from 202 voluntary SPP and 31 swine farms in Chiang Mai and Lamphun Provinces, Thailand in 2017. MRSA were screened and identified using mannitol salt agar, biochemical and antimicrobial susceptibility testing, multiplex PCR, and the SCCmec typing. The prevalence of MRSA was 7.9% (16/202) and 19.3% (6/31) among SPP and swine farms. All isolates were multidrug-resistant, and 55 of 59 isolates (93%) contained the type-IX SCCmec element. Data analysis indicated that education, working time, contact frequency, working solely with swine production, and personal hygiene were significantly related to MRSA acquisition (p < 0.05). The multivariate analysis revealed that pig farming experience, working days, and showering were good predictors for MRSA carriage among SPP (area under the curve (AUC) = 0.84). The biosecurity protocols and tetracycline use were significantly associated with MRSA detection in pig farms (p < 0.05). Hence, the active surveillance of MRSA and further development of local/national intervention for MRSA control are essential.
A person-centered examination of acculturation and psychological functioning among Chinese and Korean immigrant mothers in the United States.

Objectives: The present research used a person-centered approach to examine the acculturation styles of Chinese and Korean immigrant mothers in the United States and demographic characteristics and psychological functioning associated with each acculturation style. Method: The sample comprised 240 first-generation Chinese immigrant mothers (CIMs; M = 37.80 years, SD = 4.55) and 222 first-generation Korean immigrant mothers (KIMs; M = 36.00 years, SD = 3.69) of preschool children. Latent profile analysis was used to identify latent acculturation styles among CIMs and KIMs. We further examined whether mothers' acculturation styles were associated with their sociodemographic characteristics and psychological functioning within each cultural group. Results: Four acculturation styles were revealed among CIMs: (a) behaviorally undifferentiated/psychologically assimilated, (b) behaviorally marginalized/psychologically separated, (c) behaviorally psychologically assimilated, and (d) behaviorally integrated/psychologically undifferentiated. Three acculturation styles were uncovered among KIMs: behaviorally psychologically separated, behaviorally psychologically assimilated, and behaviorally psychologically integrated. Chinese behaviorally integrated/psychologically undifferentiated mothers and Korean behaviorally psychologically separated perceived the highest levels of coethnic concentration in their communities. Chinese behaviorally marginalized/psychologically separated mothers reported poorer psychological functioning than other Chinese mothers. Korean behaviorally psychologically separated mothers had poorer psychological functioning than other Korean mothers. Conclusions: Findings revealed the significant role of participation in the American mainstream culture for Asian immigrant mothers' psychological adjustment. The heterogeneity in the acculturation experiences of Asian immigrants in the United States was highlighted. (PsycInfo Database Record (c) 2020 APA, all rights reserved).
Seasonal changes in standing crop, primary production, and nutrient levels in a Carex rostrata wetland

Seasonal changes in above and below ground aspects of the life history of Carex rostrata Stokes were determined and used as a basis for the study of primary production and nutrient cycling in the ecosystem. Total number of shoots m2 did not vary greatly during the season, but many old shoots that had overwintered died. They were replaced by new young shoots which began to emerge in mid-July. Above ground primary production in this ecosystem was 540 g m72 yr-1 based on harvest data but 820 g m2 yr' based on weight of shoots present in permanent plots.
Ten-year survival trends of neovascular age-related macular degeneration at first presentation

Background To describe 10-year trends in visual outcomes, anatomical outcomes and treatment burden of patients receiving antivascular endothelial growth factor (anti-VEGF) therapy for neovascular age-related macular degeneration (nAMD). Methods Retrospective cohort study of treatment-naïve, first-affected eyes with nAMD started on ranibizumab before January 1, 2009. The primary outcome was time to best-corrected visual acuity (BCVA) falling ≤35 ETDRS letters after initiating anti-VEGF therapy. Secondary outcomes included time to BCVA reaching ≥70 letters, proportion of eyes with BCVA ≥70 and ≤35 letters in 10 years, mean trend of BCVA and central retinal thickness over 10 years, and mean number of injections. Results For our cohort of 103 patients, Kaplan-Meier analyses demonstrated median time to BCVA reaching ≤35 and ≥70 letters were 37.8 (95% CI 22.2 to 65.1) and 8.3 (95% CI 4.8 to 20.9) months after commencing anti-VEGF therapy, respectively. At the final follow-up, BCVA was ≤35 letters and ≥70 letters in 41.1% and 21%, respectively, in first-affected eyes, while this was the case for 5.4% and 48.2%, respectively, in a patient’s better-seeing eye. Mean injection number was 37.0±24.2 per eye and 53.6±30.1 at patient level (63.1% of patients required injections in both eyes). Conclusions The chronicity of nAMD disease and its management highlights the importance of long-term visual prognosis. Our analyses suggest that one in five patients will retain good vision (BCVA ≥70 ETDRS letters) in the first-affected eye at 10 years after starting anti-VEGF treatment; yet, one in two patients will have good vision in their better-seeing eye. Moreover, our data suggest that early treatment of nAMD is associated with better visual outcomes.
The Muscle Morphology of Elite Sprint Running.

The influence of muscle morphology and strength characteristics on sprint running performance, especially at elite level, is unclear. PURPOSE This study aimed to investigate the differences in muscle volumes and strength between male elite sprinters, sub-elite sprinters, and untrained controls; and assess the relationships of muscle volumes and strength with sprint performance. METHODS Five elite sprinters (100 m seasons best [SBE100]: 10.10 ± 0.07 s), 26 sub-elite sprinters (SBE100: 10.80 ± 0.30s) and 11 untrained control participants underwent: 3T magnetic resonance imaging scans to determine the volume of 23 individual lower limb muscles/compartments and 5 functional muscle groups; and isometric strength assessment of lower body muscle groups. RESULTS Total lower body muscularity was distinct between the groups (controls < sub-elite +20% < elite +48%). The hip extensors exhibited the largest muscle group differences/relationships (elite, +32% absolute and +15% relative [per kg] volume vs sub-elite; explaining 31-48% of the variability in SBE100), whereas the plantarflexors showed no differences between sprint groups. Individual muscle differences showed pronounced anatomical specificity (elite vs sub-elite, absolute volume range +57% to -9%). Three hip muscles were consistently larger in elite vs. sub-elite (TFL, sartorius, gluteus maximus; absolute +45-57% and relative volume +25-37%), and gluteus maximus volume alone explained 34-44% of the variance in SBE100. Isometric strength of several muscle groups was greater in both sprint groups than controls, but similar for the sprint groups and not related to SBE100. CONCLUSIONS These findings demonstrate the pronounced inhomogeneity and anatomically specific muscularity required for fast sprinting, and provides novel, robust evidence that greater hip extensor and gluteus maximus volumes discriminate between elite and sub-elite sprinters and are strongly associated with sprinting performance.
Health-Related Quality of Life in Male Patients under Treatment for Substance Use Disorders with and without Major Depressive Disorder: Influence in Clinical Course at One-Year Follow-Up

Health-related quality of life (HRQoL) assessment has interest as an indicator of degree of affectation and prognosis in mental disorders. HRQoL is impaired in both Substance Use Disorder (SUD) and Major Depressive Disorder (MDD), two conditions highly prevalent, although less studied when both are coexisting (SUD + MDD). Hence, we decided to explore HRQoL with the SF-36 survey in a sample of 123 SUD and 114 SUD + MDD patients (51 symptomatic and 63 asymptomatic of depressive symptoms) under treatment. We performed analyses to examine HRQoL among groups, and its predictive value at 3-, 6- and 12-month follow-ups through regression models. Patients with SUD + MDD had worse HRQoL than SUD patients and population norms. For Mental Health, Vitality, and General Health dimensions, lower scores were observed for SUD + MDD regardless the presence/absence of depressive symptoms. For Physical Functioning and Health Change, depressive symptomatology and not the comorbidity of SUD + MDD diagnoses explained HRQoL limitations. At 3-, 6- and 12-month follow-ups we observed two predictors of relapses, General Health for asymptomatic SUD + MDD, and Physical Functioning for SUD. Improving HRQoL in SUD + MDD may be targeted during patient’s treatment; future studies should explore the influence of HRQoL on patient’s prognosis taking into account the presence/absence of depressive symptomatology.