Miracle-dz/UniFAR-FTUs huggingface dataset:
The Effect of Market Orientation, Entrepreneurial Orientation, Innovation and Competitive Advantage on Business Performance of Indonesian MSMEs

Purpose: The objective of this study was to determine the effect of market orientation, entrepreneurial orientation, innovation, and competitive advantage on MSMEs (Micro Small and Medium Enterprises) business performance. Design/methodology/approach: This type of research is quantitative with a case study research design. The implementation of the research was carried out in Indonesia, especially in Lamongan district, East Java, Indonesia. The research subjects were MSMEs owners/managers with a total sample of 302 using SPSS-AMOS 22 SEM (Structural Equation Modeling) analysis. Findings: The results of this study indicate that there is an significant influence of market orientation, entrepreneurial orientation, competitive advantage on business performance, while innovation has no significant influence on MSMEs business performance. Research, Practical & Social implications: The theoretical implication of this research is to increase knowledge about market orientation and entrepreneurial orientation as well as increase innovation and competitive advantage to get maximum MSMEs business performance. The results of this study can provide information to the government and organizations related to MSMEs. In this case, the Office of Cooperatives and Micro Enterprises, the Office of Industry and Trade in Lamongan district, East Java, Indonesia. Originality/value: The results of the Structural Equation Modeling evaluation with the univariate normality test showed an excellent critical skewness ratio value, and the kurtosis indicated data was normally distributed, and the data is feasible to use. Than 7 methods (X2-Chi square, Sign Probability, CMIN/DF, GFI, AGFI, TLI, CFI, and RMSEA) are used to measure the fit of the model in SEM there are 6 criteria that are fit from 7 existing criteria, so it can be concluded that this measurement model has a good fit level. The results of hypothesis testing affect market orientation has a significant on MSMEs performance, entrepreneurial orientation has a significant on MSMEs performance, competitive advantage has a significant on MSMEs performance, market orientation has a significant on innovation, market orientation has a significant to competitive advantage, entrepreneurial orientation has a significant on innovation, entrepreneurial orientation has a significant on competitive advantage, competitive advantage has a significant on innovation, and innovation has not a significant on MSMEs performance.
Design of Low Crosstalk Homogeneous Multicore Fiber with Limited Cladding Diameter

A homogeneous 14-core uncoupled Multicore fiber (MCF) arranged in two rings is proposed with a view to obtaining low crosstalk transmission. Trench-assisted approach was used to minimize the crosstalk between the cores. The influence of crosstalk has been examined on both the outer and center cores for a 100 km-long transmission distance. The impact of fiber bending radius, wavelength, and trench width on crosstalk has been investigated numerically. The simulation results demonstrate that the designed MCF exhibits crosstalk less than -110 dB although the 14 cores are placed with a limited cladding diameter of 200 µm. The proposed fiber could be a good candidate for long-distance space division multiplexing (SDM) applications.
Customer Loyalty Islamic Banks in Indonesia: Service Quality Which Mediated by Satisfaction and Customer Trust

Purpose: This study aims to analyze the effect of service quality on loyalty mediated by customer satisfaction and trust. A total of 215 Islamic bank customers in the study area were sampled accidently. Theoretical framework: Theoretically, this study contributes to the gaps in the literature, especially those related to the effect of SQ on Islamic banking loyalty which is mediated by satisfaction and trust simultaneously in one research title. Practically, encouraging Islamic banking management to design SQ programs that integrate the value of satisfaction and trust in the same cultural background to gain customer support and loyalty Design/methodology/approach: There are four latent variables observed; service quality, satisfaction, trust, and loyalty with the number of indicators respectively six, four, three, and four. Data collection was carried out through interviews using a questionnaire. Data were analyzed using Smart-PLS 3.0. The validity test uses factor loading and AVE ( Average Variance Extracted ), the reliability test uses Composite reliability (CR) and Cronbach's Alpha (CA), the direct effect test uses the path analysis matrix, while the indirect effect test uses the specific indirect effects matrix. Findings: The volume of research has been increasing over the past nineteen years, although there are only a few authors, institutions and reference journals contributing to the topic’s consolidation and the countries conducting the most joint research in co- authoring for the largest volume of publications, authors and impact journals. Research, Practical & Social implications: This study concludes that customer loyalty of Islamic banks in Indonesia can be optimized through service quality which is mediated by customer satisfaction and trust. Originality/value: The results of the analysis show that the factor loading value is> 0.6 and the AVE value is> 0.5 which means that the data is valid. CR and CA values > 0.6 which means the data is reliable. The direct effect test shows that service quality, satisfaction and trust have a positive and significant effect (p-value <0.05) on loyalty. Furthermore, service quality has an indirect effect ( specific indirect effects) on customer loyalty through the mediation of satisfaction and trust.
Fifteen-year Outcomes of 1,196 Ozaki Procedures

Background: Introduced in 2007, the Ozaki procedure has become an attractive option for aortic valve disease. Our objective was to investigate outcomes of the Ozaki procedure in the original Ozaki cohort. Methods: From April 2007 to May 2021, 1,196 consecutive Ozaki procedures were performed at Toho University Ohashi Medical Center. Patient age ranged from 11 to over 90 years, 484 (60%) were male, 50 (4.2%) had previous cardiac surgery, and 155 (13%) were on dialysis. 322 (27%) had bicuspid valves and 28 (2.3%) had infective endocarditis. 651 (54%) had aortic stenosis, 289 (24%) aortic regurgitation, and 87 (7.2%) mixed. 546 (46%) underwent concomitant procedures. Clinical outcomes, echocardiograms, and follow-up data were collected and analyzed for valve performance, and time-to-event analyses were performed for reoperation and mortality. 5023 patient-years of follow-up were available for analysis, with 50% of patients followed >3.2 years and 10% >9 years. Results: Mean cardiopulmonary bypass and aortic clamp times for isolated Ozaki procedures were 151{+/-}37 and 105{+/-}29 minutes, respectively. Thirty-day mortality was 1.8% (n=22), new stroke 14 (2.6%), new dialysis 41(4.0%), and permanent pacemaker implantation 18 (1.5%). At 6 months, 5 years, and 10 years, peak/mean aortic valve gradients were 14.0/7.4, 15.5/8.0 and 15.5/8.2 mmHg, respectively, and >moderate regurgitation was 0.30%/2.9%/6.6%. Left ventricular mass index decreased from 141{+/-}52 g/m2 preoperatively to 100{+/-}1.1 g/m2 at 6 months and 90{+/-}1.8 g/m2 at 10 years. At 10 years, freedom from reoperation was 91.2% and survival 75%. Conclusion: The Ozaki procedure creates good aortic valves with stable low gradients. Regurgitation increased over time, but risk of reoperation was low, supporting continued use.
Discordance Between Self-Reported and Lab-Measured A1C Among U.S. Adults with Diabetes: Findings from the National Health and Nutrition Examination Survey (2013-2020)

Aims: To: 1) compare characteristics of those who report knowing their hemoglobin A1C (A1C) value versus those who do not; 2) determine the correlation and concordance between self-reported and lab-measured A1C; and 3) examine factors associated with a lab-measured A1C of <= 7%. Methods: This was a cross-sectional secondary data analyses of the National Health and Nutrition Examination Survey from 2013-2020. Participants >= 20 years old who reported receiving a diabetes diagnosis were included. Results: After proper sample weighting, twenty-two percent of participants reported not knowing their A1C value. Not knowing ones A1C value was associated with identifying as a racial or ethnic group other than White, having a lower income, and having less formal education (P values < 0.5). Self-reported A1C was moderately correlated with lab-measured A1C (r = 0.62, P < 0.001). Higher self-reported A1C and identifying as Black or Mexican American were associated with lower odds of good glycemic control. Conclusions: Many patients with diabetes did not know their A1C, and among those that did, the value was often inaccurate. Even when patients knew their A1C, the correlation between self-reported and lab-measured A1C was only moderate. Clinicians should evaluate and, if needed, enhance patient knowledge of A1C.
A teacher professional development course on quantum technologies: discussion of results

We first present the evaluation of a professional development course for in-service teachers on quantum technologies which was initially presented at the GIREP Malta 2020 webinar about halfway into its development. The primary purpose of the course was to enhance physics teachers’ knowledge and awareness of topics related to quantum computation and quantum information, and of their relevance for technological advancement. However, our choice was not to present such topics as a simple addition to high school physics in the final year, but rather to inspect the whole physics and mathematics curriculum in the search for a longitudinal perspective, roughly based on the relationship between physics and computation, which could culminate in the treatment of quantum information topics. In the present contribution, we will focus on the educational outcomes of the course in terms of teacher appreciation, interest level and judgement of usefulness coming from both a final questionnaire and individual interviews. We will also describe a follow-up course structured to frame the topic from the standpoint of curriculum design and action research projects currently underway.
Experimental Study on the Damage Performance of the Zr-based Amorphous Alloy Jet against Steel Target

To study the damage performance of the Zr-based amorphous alloy jet against metal target, the static explosive experiments were conducted with the simulated target of 45# steel in comparison with the copper jet. As shown by the experimental results, the depth of penetration (DOP) of the amorphous alloy jet declines with the stand-off distance after it reaches a level higher than 3.0 charge diameter (CD). Under the same conditions, the DOP of the amorphous alloy jet is less than that of the copper jet, and no plugging is found during penetration of the steel target. Moreover, the perforation area of the amorphous alloy jet increases with the stand- off distance. With a large stand-off, the amorphous alloy jet appears to be dispersed and granular during flight, forming the group of erosion holes on the target plate rather than a huge single perforation. Evident chemical reactions took place during the penetration of the amorphous alloy jet. The combined damage effects of both the penetration and explosion allows the shaped charge to obtain larger perforations, while exerting an adverse impact on the DOP as well.
Coronal Heating as Determined by the Solar Flare Frequency Distribution Obtained by Aggregating Case Studies

Flare frequency distributions represent a key approach to addressing one of the largest problems in solar and stellar physics: determining the mechanism that counterintuitively heats coronae to temperatures that are orders of magnitude hotter than the corresponding photospheres. It is widely accepted that the magnetic field is responsible for the heating, but there are two competing mechanisms that could explain it: nanoflares or Alfvén waves. To date, neither can be directly observed. Nanoflares are, by definition, extremely small, but their aggregate energy release could represent a substantial heating mechanism, presuming they are sufficiently abundant. One way to test this presumption is via the flare frequency distribution, which describes how often flares of various energies occur. If the slope of the power law fitting the flare frequency distribution is above a critical threshold, α = 2 as established in prior literature, then there should be a sufficient abundance of nanoflares to explain coronal heating. We performed >600 case studies of solar flares, made possible by an unprecedented number of data analysts via three semesters of an undergraduate physics laboratory course. This allowed us to include two crucial, but nontrivial, analysis methods: preflare baseline subtraction and computation of the flare energy, which requires determining flare start and stop times. We aggregated the results of these analyses into a statistical study to determine that α = 1.63 ± 0.03. This is below the critical threshold, suggesting that Alfvén waves are an important driver of coronal heating.
Health aspects of vegan diets among children and adolescents: a systematic review and meta-analyses

Health effects of vegan diets among children are a controversial public health topic. Thus, we evaluated a broad range of health outcomes among vegan children and adolescents aged 0 to 18 years by a systematic review and meta-analyses. 17 studies met the inclusion criteria (16 cross-sectional studies, one randomized trial). Meta-analyzes showed lower intakes of protein (%E MD[95%CI]: -3.54 [-5.08, -2.00]) and higher intakes of fiber (g/1000kcal MD[95%CI]: 8.01 [6.96, 9.06]) in vegans compared to omnivores. Non-meta-analyzable studies showed lower calorie, vitamin B12 (when not using supplements) and selenium intakes, as well as lower blood levels of ferritin and vitamin B12. By contrast, vegans had significantly higher intakes of folate, vitamin C and iron. Levels of several cardiometabolic biomarkers (cholesterol, LDL) and indicators of bone health (vitamin D and calcium intake, vitamin D blood levels, bone mineral density) were lower in vegans. Risk of Bias was rated as high or very high in seven out of 17 primary studies. The Certainty of the Evidence was low or very low in all meta-analyses. Vegan children and adolescents following a vegan diet may have a beneficial cardiovascular risk profile but may be at risk for impaired bone health.
Identifying Quantitatively Differential Chromosomal Compartmentalization Changes and Their Biological Significance from Hi-C data using DARIC

Background Chromosomal compartmentalization plays a critical role in maintaining proper transcriptional programs in cell differentiation and oncogenesis. However, currently the prevalent method for comparative analysis of compartmentalization landscapes between different cell types is limited to the qualitative switched compartments. Results To identify genomic regions with quantitatively differential compartmentalization changes from genome-wide chromatin conformation data like Hi-C, we developed a computational framework named DARIC. DARIC includes three modules: compartmentalization quantification, normalization, and differential analysis. Comparing DARIC with the conventional compartment switching analysis reveals substantial regions characterized by quantitatively significant compartmentalization changes without switching. These changes are accompanied by changes in gene expression, chromatin accessibility, H3K27ac intensity, as well as the interactions with nuclear lamina proteins and nuclear positioning, highlighting the functional importance of such quantitative changes in gene regulation. We applied DARIC to dissect the quantitative compartmentalization changes during human cardiomyocyte differentiation and identified two distinct mechanisms for gene activation based on the association with compartmentalization changes. Using the quantitative compartmentalization measurement module from DARIC, we further dissected the compartment variability landscape in the human genome by analyzing a compendium of 32 Hi-C datasets from 4DN. We discovered an interesting correlation between compartmentalization variability and sub-compartments. Conclusions DARIC is a useful tool for analyzing quantitative compartmentalization changes and mining novel biological insights from increasing Hi-C data. Our results demonstrate the functional significance of quantitative compartmentalization changes in gene regulation, and provide new insights into the relationship between compartmentalization variability and sub-compartments in the human genome.
Towards High-Fidelity Aerostructural Optimization using a coupled ADjoint Approach

The tools required to perform high-fidelity aerostructural optimization are developed. Given the highly coupled nature of the aerostructural problem, a multidisciplinary feasible (MDF) approach is used for the framework. This approach is facilitated by a lagged-coupled adjoint, implemented using the ADjoint technique to sensitivity analysis. The ADjoint technique allows for the generation of very accurate and efficient adjoint sensitivities. The lagged-coupled adjoint system, which is equivalent to using a block-Jacobi method on the full coupled adjoint system, is solved using a pair of linear solvers. The structural portion of the system is solved using FEAP’s linear solver, while the CFD portion of the system is solved using PETSc. To demonstrate the accuracy of the coupled ADjoint, the sensitivities computed using the lagged-coupled approach are verified against complex-step sensitivities.
Senolytic therapy to modulate the progression of Alzheimer’s Disease (SToMP-AD) – Outcomes from the first clinical trial of senolytic therapy for Alzheimer’s disease

Cellular senescence has been identified as a pathological mechanism linked to tau and amyloid beta (Aβ) accumulation in mouse models of Alzheimer’s disease (AD). Clearance of senescent cells using the senolytic compounds dasatinib (D) and quercetin (Q) reduced neuropathological burden and improved clinically relevant outcomes in the mice. Herein, we conducted a vanguard open-label clinical trial of senolytic therapy for AD with the primary aim of evaluating central nervous system (CNS) penetrance, as well as exploratory data collection relevant to safety, feasibility, and efficacy. Participants with early-stage symptomatic AD were enrolled in an open-label, 12-week pilot study of intermittent orally-delivered D+Q. CNS penetrance was assessed by evaluating drug levels in cerebrospinal fluid (CSF) using high performance liquid chromatography with tandem mass spectrometry. Safety was continuously monitored with adverse event reporting, vitals, and laboratory work. Cognition, neuroimaging, and plasma and CSF biomarkers were assessed at baseline and post-treatment. Five participants (mean age: 76±5 years; 40% female) completed the trial. The treatment increased D and Q levels in the blood of all participants ranging from 12.7 to 73.5 ng/ml for D and 3.29–26.30 ng/ml for Q. D levels were detected in the CSF of four participants ranging from 0.281 to 0.536 ng/ml (t(4)=3.123, p=0.035); Q was not detected. Treatment was well-tolerated with no early discontinuation and six mild to moderate adverse events occurring across the study. Cognitive and neuroimaging endpoints did not significantly differ from baseline to post-treatment. CNS levels of IL-6 and GFAP increased from baseline to post-treatment (t(4)=3.913, p=008 and t(4)=3.354, p=0.028, respectively) concomitant with decreased levels of several cytokines and chemokines associated with senescence, and a trend toward higher levels of Aβ42 (t(4)=−2.338, p=0.079). Collectively the data indicate the CNS penetrance of D and provide preliminary support for the safety, tolerability, and feasibility of the intervention and suggest that astrocytes and Aβ may be particularly responsive to the treatment. While early results are promising, fully powered, placebo-controlled studies are needed to evaluate the potential of AD modification with the novel approach of targeting cellular senescence.
Molecular mechanisms protecting centromeres from self-sabotage and implications for cancer therapy

Abstract Centromeres play a crucial role in DNA segregation by mediating the cohesion and separation of sister chromatids during cell division. Centromere dysfunction, breakage or compromised centromeric integrity can generate aneuploidies and chromosomal instability, which are cellular features associated with cancer initiation and progression. Maintaining centromere integrity is thus essential for genome stability. However, the centromere itself is prone to DNA breaks, likely due to its intrinsically fragile nature. Centromeres are complex genomic loci that are composed of highly repetitive DNA sequences and secondary structures and require the recruitment and homeostasis of a centromere-associated protein network. The molecular mechanisms engaged to preserve centromere inherent structure and respond to centromeric damage are not fully understood and remain a subject of ongoing research. In this article, we provide a review of the currently known factors that contribute to centromeric dysfunction and the molecular mechanisms that mitigate the impact of centromere damage on genome stability. Finally, we discuss the potential therapeutic strategies that could arise from a deeper understanding of the mechanisms preserving centromere integrity.
COMMUTATIVE IDEAL THEORY WITHOUT FINITENESS CONDITIONS: IRREDUCIBILITY IN THE QUOTIENT FIELD

Let R be an integral domain and let Q denote the quotient field of R. We investigate the structure of R-submodules of Q that are Q-irreducible, or completely Q-irreducible. One of our goals is to describe the integral domains that admit a completely Q-irreducible ideal, or a nonzero Q-irreducible ideal. If R has a nonzero finitely generated Q-irreducible ideal, then R is quasilocal. If R is integrally closed and admits a nonzero principal Q-irreducible ideal, then R is a valuation domain. If R has an m-canonical ideal and admits a completely Q-irreducible ideal, then R is quasilocal and all the completely Q-irreducible ideals of R are isomorphic. We consider the condition that every nonzero ideal of R is an irredundant intersection of completely Q-irreducible submodules of Q and present eleven conditions that are equivalent to this. We classify the domains for which every nonzero ideal can be represented uniquely as an irredundant intersection of completely Q-irreducible submodules of Q. The domains with this property are the Prufer domains that are almost semiartinian, that is, every proper homomorphic image has a nonzero socle. We characterize the Prufer or Noetherian domains that possess a completely Qirreducible ideal or a nonzero Q-irreducible ideal.