Miracle-dz/UniFAR-FTUs huggingface dataset:
Robust Laughter Detection in Noisy Environments

We investigate the problem of automatically identifying and extracting laughter from audio ﬁles in noisy environments. We conduct an empirical evaluation of several machine learning models using audio data of varying sound quality, ﬁnding that while previously published methods work relatively well in controlled environments, performance drops precipitously in real-world settings with background noise. In the process, we contribute a new dataset of laughter annotations on top of the existing AudioSet corpus, with precise segmentations for the start and end points of each laugh, and we present a new approach to laughter detection that performs comparatively well in uncontrolled environments. We discuss the utility of our approach as well as the importance of understanding the variability of model performance in a range of real-world testing environments.
Visualization Task Abstraction from Multiple Perspectives

— Applied information visualization design and evaluation involves a mapping between a domain problem and appropriate visual encoding and interaction techniques. This mapping translates a domain-speciﬁc workﬂow into abstract visualization tasks , which facilitates the comparison of visualization usage across application domains; the mapping also applies in reverse, whenever practitioners aim to contextualize novel visualization techniques. I propose four perspectives on visualization task abstraction: the synthesis perspective describes our recent typology of abstract visualization tasks. The remaining three perspectives involve validating this typology in applied settings: a post-deployment evaluation of visualization utility in the domain of investigative journalism, an interview study spanning 11 scientiﬁc research domains pertaining to visualization tasks for dimensionally-reduced data, and a visualization design study project in the domain of energy usage analysis.
Study the effect of two organic fertilizers, methods of fertilization on productivity, pests and predatory insects associated with eggplant under modified climatic condition

This study investigated the effects of two organic fertilizer (compost tea and humic acid) compared to chemical fertilizer on plant growth, productivity, pests and predatory insects associated with eggplant Solanum melongena var. Black beauty under net house in 1st of April at 2019 and 2020 seasons. Application of fertilizers through fertigation enhanced significantly number of leaves, stem fresh weight, average fruit weight and total fruit yield. Moreover, stem diameter, nitrogen content in leaves (%), phosphorus content in leaves (%), potassium content in leaves (%), number of fruits and total yield were enhanced significantly due to using compost tea. However, using the humic acid cause a significant enhancement in number of shoots, number of leaves, stem diameter and leaves fresh weight. In addition, application of compost tea through the fertigation cause a significant superiority in number of shoots, nitrogen content in leaves (%), phosphorus content in leaves (%), potassium content in leaves (%), number of fruits, average fruit weight and total yield. The highest significant values of leaves fresh weight and stem dry weight were mainly due using humic acid through foliar application. Three main pest species and seven different predators' species were recorded associated with pests on eggplant. The application of foliar and fertigation compost tea increased pest populations significantly compared with humic acid and control. But also, increase the predators' population.
Influence of the choice of insolation forcing on the results of a conceptual glacial cycle model

Abstract. Over the Quaternary, the ice volume variations are “paced” by the astronomy. However, the precise way in which the astronomical parameters influence the glacial-interglacial cycles is not clear. The origin of the 100 kyr cycles over the last million year and of the switch from 40 kyr to 100 kyr cycles over the Mid Pleistocene Transition remain largely unexplained. By representing the climate system as oscillating between two states, glaciation and deglaciation, switching once a glaciation and a deglaciation thresholds are crossed, the main features of the ice volume record can be reproduced (Parrenin and Paillard, 2012). However, previous studies have only focused on the use of a single summer insolation as input. Here, we use a simple conceptual model to test and discuss the influence of the use of different summer insolation forcings, having different contributions from precession and obliquity, on the model results. We show that some features are robust. Specifically, to be able to reproduce the frequency shift over the Mid Pleistocene Transition, the deglaciation threshold needs to increase over time, independently of the summer insolation used as input. The quality of the model data agreement however depends on the chosen type of summer insolation and time period considered.
OARRR_A_245662 41..46

Nur Atik 1,2 Rira Uji Hayati 3 Laniyati Hamijoyo 2,4 1Department of Biomedical Sciences, Faculty of Medicine, Padjadjaran University, Bandung, West Java, Indonesia; 2Lupus Study Centre, Immunology Study Group, Padjadjaran University/Hasan Sadikin Hospital, Bandung, West Java, Indonesia; 3Faculty of Medicine, Padjadjaran University, Bandung, West Java, Indonesia; 4Department of Internal Medicine, Padjadjaran University/Hasan Sadikin Hospital, Bandung, West Java, Indonesia Purpose: Systemic lupus erythematosus (SLE) is an autoimmune disease with high mortality and morbidity rates, one of the causes of which is cardiovascular events. Dyslipidaemia is known to be one of the main risk factors for cardiovascular disorders and can be induced by steroid therapy, which is commonly administered to SLE patients. This study aimed to determine whether there is a correlation between steroid dose and lipid profile in SLE patients. Methods: The study was a correlative analytic study with a cross-sectional design. Data were obtained from the Hasan Sadikin Lupus Registry (HSLR) and the medical records of patients registered in the Rheumatology Division, Dr Hasan Sadikin Hospital, Bandung, from 2008 to 2019. Inclusion criteria were SLE patients who had undergone lipid profile examination and received steroid therapy. We excluded patients taking cyclosporine A or statins, and patients treated with steroids for less than a year. A simple random sampling method was performed and Pearson’s correlation test was used for the analysis. Results: We recruited 41 female patients with an average age of 30.88 ± 9.29 years old. The average dose of steroid in this study was 5.63 mg/day, while the average lipid profile was 177.51 mg/dL, 105.22 mg/dL, 61 mg/dL and 92.98 mg/dL for total cholesterol, low-density lipoprotein (LDL), high-density lipoprotein (HDL) and triglycerides, respectively. Correlations between steroid dose and total cholesterol (r = 0.375; p = 0.016), and between steroid dose and triglyceride level (r = 0.416; p = 0.007) were statistically significant in SLE patients. However, this study showed no correlation between steroid and HDL level (r = 0.206; p = 0.196) or LDL level (r = 0.308; p = 0.05). Conclusion: This study showed that the applied steroid dose in SLE patients correlated with total cholesterol and triglyceride levels, but not with HDL or LDL.
Epidemiology, Diagnostics, and Treatment of Narcolepsy in Germany: The DORMIO Study

Objectives: This study aimed to investigate the prevalence, incidence, and real-world diagnostic and treatment patterns, healthcare resource utilization (HCRU), and associated costs of narcolepsy in Germany. Methods: This study was based on German claims data (2013–2018). Any patient with at least two outpatient specialist diagnoses and/or one inpatient diagnosis of narcolepsy was eligible for inclusion. Three cohorts were specified: 1) narcolepsy-prevalent patients alive on July 1, 2017; 2) narcolepsy-incident patients; and 3) newly treated patients. Descriptive analyses of the outcome measures were conducted. Results: We identified 133 prevalent narcolepsy patients (mean age: 46.2 years, 36.3% female), 71 incident patients, and 41 treatment starters. The prevalence of narcolepsy was 3.1–9.1 per 100,000 persons within the German population; the cumulative incidence between July 1, 2017, and June 30, 2018, was 0.83/100,000 persons. Among the incident patients, 62.0% underwent at least one predefined diagnostic procedure. Modafinil was the most prescribed medication for the treatment starters (46.3%) and prevalent patients (24.1%), but 59.4% of the prevalent patients did not receive any narcolepsy-specific pharmacological treatment. Prevalent patients with narcolepsy consulted physicians significantly more often than a healthy matched control group and experienced more all-cause hospitalizations. The mean total direct healthcare costs were higher for narcolepsy patients by €2,429 per patient-year. Conclusions: Not all narcolepsy patients undergo appropriate diagnostic procedures or narcolepsy-specific medications, as indicated by the treatment guidelines. More emphasis on the optimization of the management of this disease is needed, given its high prevalence and associated economic burden.
OCCURRENCE OF ORAL SQUAMOUS CELL CARCINOMA IN PATIENTS WITHOUT PREDISPOSING ORAL HABITS

Aim To assess the occurrence of oral squamous cell carcinoma in patients without predisposing oral habits – In a hospital based population. Materials and methods This retrospective study was performed on the cases referred to Oral cancer institute –of a reputed University in south India during June 2015 to December 2017. The details of the patients were collected, tabulated and statistical analysis was done. Results Non smoking and non drinking female patients are becoming a distinct group in oral squamous cell carcinoma. The male to female ratio (those without habits) is 1:2. The factors that could contribute to this phenomenon could include hormonal or viral infection such as HPV. Conclusion There is a relative increase of non smoking, non drinking patients associated OSCC, particularly females. This trend needs to be studied in detail as it is vital for an early diagnosis and this could facilitate a better prognosis.
Contributions to Generalized Derivation on Prime Near-Ring with its Application in the Prime Graph

In this paper, we discuss the notion of prime nearring, which was introduced by Bell and Mason (1987) and Wang (1994) independently. Recently, many authors have investigated commutativity of prime and semi-prime rings admitting suitably constrained derivations (see Daif and Bell (1992), Gölba3i and Koç (2009) for references). Daif and Bell (1992) showed that a prime ring R must be commutative if it admits a derivation d such that either d([x, y]) = [x, y] or d([x, y]) = −[x, y] ∀ x, y ∈ I, where I is a non-zero ideal of R. Beck (1988) linked a commutative ring R to a graph by using the elements R as vertices and any two vertices x, y are adjacent if and only if x 6= y and xy = 0. The zero-divisor graph of a commutative ring R is a graph with the set of non-zero zero-divisors of R as the vertices and any two vertices x, y are adjacent if and only if x 6= y and xy = 0. Some comparable results on near-rings have also been derived Beidar et al. (1996), Boua and Oukhtite (2011), Gölba3i and Koç (2009). The prime graph of a near-ring is a graph with vertices as the set of elements of N and edges as the set of vertex pair {x, y} such that xNy = 0. Indeed N is prime if and only if prime graph is a star
Haematological and Haemostatic Changes Associated with Major Depressive Disorder among Nigerians.

Background: A link between major depressive disorder (MDD) and haematological as well as co-agulation disorders has been postulated. This study aims to evaluate haematological and haemostatic changes among Nigerians with major depressive disorder Methods: Two hundred volunteers consisting of an equal number of individuals diagnosed with major depressive disorder (MDD) based on DMS-IV criteria and apparently healthy control participated in this study. The blood sample was collected into tri-sodium citrate K2EDTA bottles respectively and was evaluated for some haemostatic parameters , using ELISA, Clauss, Quick’s One Stage, Proctor and Rapaport’s methods. Results: The mean WBC, hemoglobin and differential lymphocyte were significantly higher among MDD total volunteers (p < 0.001). The red cell indices and platelet count were lower among MDD (p <0.001). Also the prothrombin time (PT), fibrinogen, protein-C and erythrocytes sedimentation rate (ESR) were all raised (p <0.001) among volunteers with MDD. Positive associations existed be-tween MCV and RBC (r: 0.364; p<0.001), PT and APTT (r: 0.319 p <0.001), APTT and fibrinogen (r: 0.239, p = 0.017) as well as PT and fibrinogen (r: 0.275 p = 0.006) at 95% confidence interval. Conclusion: Changes in total leucocytes count, lymphocytes values and haemostatic parameters among volunteers with depression may impacts deleterious effects on the immune response as well as haemostatic homeostasis, while decreased red cell indices may suggest occult nutritional anaemia.
Circulating erythroblast abnormality associated with systemic pathologies may indicate bone marrow damage

ABSTRACT Background: The circulating rare cell population is diverse and rich in diagnostic information. Its characterization and clinical exploitation by cell-based liquid biopsy is an ongoing research task. Bone marrow is one of the major contributors to the peripheral blood rare cell population and, consequently, determines individual rare cell profiles thus depending on bone marrow health status. Bone marrow damage has been associated with aggressive or late-stage systemic diseases and egress of various bone marrow cells into the blood circulation. The association of quantity and heterogeneity of circulating erythroblast with bone marrow damage is of particular interest. Methods: Circulating CD71high/CD45-/Hoechsthigh blast cells from healthy, noncancer- and cancer-afflicted donors were enriched by CD45 depletion and analyzed by immunofluorescence microscopy. Results: A new finding of aberrant and mitotic circulating erythroid-like cells that appear similar across blood donors afflicted with various systemic pathologies is reported. Further presented is a classification of said erythroblast-like cells in nine subcategories according to morphological differences between phenotypically similar cells. Conclusion: Aberrant and mitotic bone marrow-derived rare circulating erythroid-like cells can be detected in the blood of afflicted individuals but not in healthy donors, suggesting the cause of bone marrow damage.
Longitudinal Changes in Running Gait Asymmetries and Their Relationship to Personal Record Race Times in Collegiate Cross Country Runners

Minimizing between-limb asymmetries during running is often a goal of training, as increased asymmetries are related to decreased efficiency and increased energy expenditure. However, it is unknown if asymmetries change with increased running exposure or are related to actual race performance. The purpose of this study was to determine (1) if pre-season asymmetries changed year-to-year among collegiate cross country runners, and (2) if these asymmetries were associated with within-season personal records (PRs). Pre-season biomechanical test results and race performance data were analyzed for 54 unique runners (28 female) across six seasons, totaling 152 assessments (age: 19.1 (0.9) years, height: 1.71 (0.10) m, weight: 61.7 (7.7) kg (values = mean [standard deviation])). Biomechanical asymmetries included ground reaction forces; ground contact time; base of gait; foot inclination angle; and peak hip flexion, hip extension, hip adduction, pelvic drop, knee flexion, and ankle dorsiflexion. Year of collegiate eligibility was used to quantify training exposure. Asymmetries during running did not change across years of eligibility (p ≥ 0.12), except propulsive impulse, which decreased over time (p = 0.03). PR times were faster with decreased propulsive impulse asymmetry and increased AVLR and peak ankle dorsiflexion asymmetries. This is the first study to assess longitudinal asymmetries over time and provide potential targets for interventions aimed at modifying asymmetries to improve performance.
Screening of Amodiaquine for its in vitro Anti-cancer Activity on Breast Cancer Cell Lines- a Case Study for Drug Reprofiling

Background: Cancer is one of the foremost contributors to global disease bur den and constantly requires new therapeutic options. The development of new drugs has failed to keep up with its incidence. Hence, drug reprofiling strategies are emerging as novel therapeutic options. The study aimed to evaluate the anti-cancer activity of amodiaquine (anti-malarial drug) using a combination of murine and human breast cancer cell lines Methods: Amodiaquine was authenticated by ultra-violet spectrophotometry, high- performance liquid chromatography and 1D nuclear magnetic resonance. In vitro cytotoxicity of amodiaquine was evaluated against three breast cancer cell lines. MDA-MB-453, 4T1 and MDA-MB-231 cells were incubated with the drug at different concentrations (0.78, 1.56, 3.13, 6.25, 12.50, 25.00, 50.00, 100.00 μM) for 72 h, after which cell viability testing was conducted using the cell counting kit-8 assay. Negative control in which no drug was added to the cells was also evaluated. The flow cytometry analysis of MDA-MB-231 cells when treated with amodiaquine was also evaluated by a flow cytometer using annexin V/propidium iodide staining assay. Results: Cell viability studies showed that the IC50 values of amodiaquine on MDA-MB-453, 4T1, and MDAMB-231 cells were 6.48 ± 1.12, 10.50 ± 1.17, and 19.23 ± 1.16 μM, respectively. The flow cytometry analysis of MDA-MB-231 cancer cells treated with amodiaquine showed cancer cell death by necrosis. Conclusion: This study has shown that amodiaquine may be potentially reprofiled as an anti-cancer agent in managing androgen receptor-positive / HER-2 positive and triple-negative breast cancer types. An additional probable mechanism of action of anti-cancer activity of amodiaquine was found to be necrosis .
Usefulness of Prostate-Specific Antigen Density as an Indicator for Recommending Prebiopsy Magnetic Resonance Imaging to Prevent Missed Prostate Cancer Diagnoses

Purpose: To identify the indication for recommending prebiopsy magnetic resonance imaging (MRI) to prevent prostate cancer missed diagnoses in cases without prebiopsy MRI.Materials and Methods: Between January 2017 and September 2020, 585 patients suspected with prostate cancer underwent prostate biopsy after MRI. For patients with visible lesions, MRI-targeted biopsy using an image-based fusion program was performed in addition to the 12- core systematic biopsy. Patients for whom MRI was performed in other institutions (n=4) and patients who underwent target biopsy alone (n=7) were excluded.Results: Of 574 patients (median prostate-specific antigen [PSA] level, 6.88 ng/mL; mean age, 68.2 years), 342 (59.6%) were diagnosed with prostate cancer (visible lesions=312/449 [69.5%]; nonvisible lesions=30/123 [24.0%]). The detection rates of visible lesions stratified using the Prostate Imaging Reporting and Data System score (3 vs. 4 vs. 5) were 30.9% (54 of 175), 61.2% (150 of 245), and 90.1% (127 of 141), respectively. Multivariate analysis showed that PSA density was a significant factor for presence of visible lesions, prostate cancer, and significant prostate cancer diagnosis. Among patients with positive lesions, 27 (8.2%) were diagnosed with prostate cancer concomitant with negative systematic biopsy results. A PSA density of 0.15 ng/mL/cm3 was identified as the significant cutoff value for predicting positive target biopsy in groups with negative systematic biopsy. Sixty of the negative target lesions (26.1%) were diagnosed using systematic biopsy.Conclusions: To maximize cancer detection rates, both targeted and systematic biopsies should be implemented. PSA density was identified as a useful factor for recommending prebiopsy MRI to patients suspected with prostate cancer.
Effect of Masticatory Movement Using Gum on Walking and Cycling: A Randomized Crossover Design

PURPOSE: Gum chewing stimulates the sympathetic nervous system and increases energy consumption. However, the effect of mastication on physical activity remains unclear. This study aimed to investigate the effect of gum masticatory movement on physiological markers related to walking and muscle activation during cycling in different patient groups.METHODS: Using a randomized crossover design, 25 participants participated in walking trials with a 1-week washout; the trials included chewing gum (GUM), taking a candy with the same ingredients as the gum (CAN), and no ingestion (CON). Energy expenditure (EE), metabolic equivalent (MET), oxygen consumption (VO2), and heart rate were measured using a portable metabolic device. The walking distance was also calculated. In the cycling experiment, the other 19 participants randomly completed 7 minutes of the three trials (GUM, CAN, CON) with a 15-minute break. The mean cycling period (MCP), cycle number (CN), coefficient of variation of the cycling period (CV), and integrated electromyography (iEMG) results were measured using the Delsys Trigno™ Wireless EMG System.RESULTS: The walking distance was significantly higher in the GUM group than in the CAN and CON groups by an average of 78 m (7.4%, p<.05). Comparing the GUM and CON groups, EE, METs, and VO2 demonstrated a partially significant increase after 15 minutes. In the cycling experiment, there were no significant differences in the effects of the trials on cycling performance (MCP, CN, CV). However, significant differences were observed in the GUM group for the iEMG results.CONCLUSIONS: Our study results suggest that gum chewing improves physical performance, such as walking distance, and improves energy metabolism, such as EE and METs. Additionally, it can influence the improvement in the lower limb muscle activity during cycling.
Structural, optical and dielectric studies of wurtzite-type CdS quantum dots green synthesised using Ocimum sanctum (Tulsi) leaf extract

Present study reports the synthesis of CdS quantum dots (QDs) using Ocimum sanctum (Tulsi) leaf extract by green chemical method. The as-prepared QDs are characterised by different analytical methods. FTIR analysis indicates that the phytochemicals present in Tulsi leaf extract play an important role in controlling the size of the particle and its morphology. The structural properties and surface morphology studies are carried out by powder XRD and SEM with EDX. PXRD patterns revealed the hexagonal structure (wurtzite) for all CdS QDs. The average crystallite size lies in the range of 3.6–3.0 nm which decreases with the increase of the extract concentration. The lattice parameters of the pure and capped CdS QDs are found to be smaller than that of their bulk analogue. The EDAX study confirms the purity of all the prepared samples. The optical study is done by UV-vis spectroscopy and the particle sizes are estimated by an empirical method, which are in good agreement with those obtained from PXRD analysis. Dielectric constant of the QDs is obtained at room temperature at different frequencies where the frequency dependence is pronounced at the lower frequencies. It is noted that the band gap of the capped CdS QDs systematically increases with the increase of the extract concentration whereas the particles size and dielectric constant of these samples decreases with the increasing amount of the extract.