Miracle-dz/UniFAR-FTUs huggingface dataset:
An Integrated Approach of GRA Coupled with Principal Component Analysis for Multi-Optimization of Shielded Metal Arc Welding (SMAW) Process

Welding distortion is a critical issue as it leads to severe deterioration of structural integrity of welded work piece and dimensional precision. This study aims at studying the effects of shielded metal arc welding (SMAW) parameters on the evolution of mechanical properties, including tensile strength, impact toughness, and hardness, along with angular distortion on a welded joint from SA 516 grade 70. Such parameters are analyzed and optimized by employing the Taguchi method and Grey relational analysis. SA 516 grade 70 is commercially used for fabrication of storage tanks, boilers and pressure vessels. SMAW is investigated with three levels of root gap, groove angle, electrode diameter, and pre-heat temperature, which were varied on a butt joint in flat (1 G) position to determine their effects on response variables at room temperature. Nine experiments were designed using a Taguchi L9 orthogonal array, welded according to American Society of Mechanical Engineers (ASME) section IX, and samples were prepared and tested as per ASTM A 370. The Taguchi method and Grey relational analysis were employed to observe the most significant parameters and optimal levels that synergically yield improved responses. Results are validated by conducting confirmatory experiments that show good agreement with optimum results.
Influence of trap modifications and environmental predictors on capture success of southern flying squirrels

Sherman traps are the most commonly used live traps in studies of small mammals and have been successfully used in the capture of arboreal species such as the southern flying squirrel (Glaucomys volans). However, southern flying squirrels spend proportionately less time foraging on the ground, which necessitates above-ground trapping methods and modifications of capture protocols. Further, quantitative estimates of the factors affecting capture success of flying squirrel populations have focused solely on effects of trapping methodologies. We developed and evaluated the efficacy of a portable Sherman trap design for capturing southern flying squirrels during 2015–2016 at the Alice L. Kibbe Field Station, Illinois, USA. Additionally, we used logistic regression to quantify potential effects of time-dependent (e.g., weather) and time-independent (e.g., habitat, extrinsic) factors on capture success of southern flying squirrels. We recorded 165 capture events (119 F, 44 M, 2 unknown) using our modified Sherman trap design. Probability of capture success decreased 0.10/1° C increase in daily maximum temperature and by 0.09/unit increase (km/hr) in wind speed. Conversely, probability of capture success increased by 1.2/1° C increase in daily minimum temperature. The probability of capturing flying squirrels was negatively associated with trap orientation. When tree-mounted traps are required, our modified trap design is a safe, efficient, and cost-effective method of capturing animals when moderate weather (temp and wind speed) conditions prevail. Further, we believe that strategic placement of traps (e.g., northeast side of tree) and quantitative information on site-specific (e.g., trap location) characteristics (e.g., topographical features, slope, aspect, climatologic factors) could increase southern flying squirrel capture success. © 2017 The Wildlife Society.
Mixed-breed guarding dogs reduce conflict between goat herders and native carnivores in Patagonia

Goat husbandry is the main rural livelihood in the northern Patagonian steppe of Argentina, and herders kill any carnivore that they believe threatens their herds, including the endangered Andean cat (Leopardus jacobita). We evaluated the use of local, medium- sized, mixed-breed guarding dogs to reduce predation and retaliatory killing of carnivores. We interviewed 64 herders, and delivered 37 puppies to 25 herders. Most economic loss was attributed to cougars (Puma concolor) and culpeos (Lycalopex culpaeus). All herders with dogs that reached the working stage reported reduced rates of predation, and 88% reported that they no longer kill carnivores. Among herders who were not using dogs, 89% of them reported increased predation, and 100% of them confi rmed that they kill carnivores. Mixed- breed dogs can be effective in reducing both predation losses and retaliatory killing, but their success depends on the ability and willingness of herders to train and use them properly.
High contrast vacuum nuller testbed (VNT) contrast, performance, and null control

Herein we report on our Visible Nulling Coronagraph high-contrast result of 109 contrast averaged over a focal plane region extending from 1 – 4 λ/D with the Vacuum Nuller Testbed (VNT) in a vibration isolated vacuum chamber. The VNC is a hybrid interferometric/coronagraphic approach for exoplanet science. It operates with high Lyot stop efficiency for filled, segmented and sparse or diluted-aperture telescopes, thereby spanning the range of potential future NASA flight telescopes. NASA/Goddard Space Flight Center (GSFC) has a well-established effort to develop the VNC and its technologies, and has developed an incremental sequence of VNC testbeds to advance this approach and its enabling technologies. These testbeds have enabled advancement of high-contrast, visible light, nulling interferometry to unprecedented levels. The VNC is based on a modified Mach-Zehnder nulling interferometer, with a “W” configuration to accommodate a hex-packed MEMS based deformable mirror, a coherent fiber bundle and achromatic phase shifters. We give an overview of the VNT and discuss the high-contrast laboratory results, the optical configuration, critical technologies and null sensing and control.
Combined use of high-sensitivity ST2 and NT-proBNP for predicting major adverse cardiovascular events in coronary heart failure.

BACKGROUND Elevated serum soluble ST2 (sST2) level is marker of poor prognosis in chronic heart failure (HF). N-terminal pro-brain natriuretic peptide (NT-proBNP) is an important biomarker in cardiovascular diseases. This study aimed to address the incremental usefulness of the combined use of high-sensitivity sST2 and NT-proBNP for predicting the risk of major adverse cardiovascular events (MACEs) in patients with coronary heart disease (CHD). METHODS We used patient data along with data established by our research group to compare the performance of a combination of biomarkers reflecting ventricular fibrosis, remodeling, stretch and deterioration of cardiac function (sST2 and NT-proBNP) with that of established mortality risk factors [age, diabetes, systolic blood pressure, diastolic blood pressure, left ventricular ejection fraction (LVEF), body mass index (BMI), creatinine (Cr), uric acid (UA), glucose (Glu)] in stratifying the risk of MACEs in CHD patients. RESULTS The median follow-up period was 3.9 years, during which time there were 3,724 cases with CHD, 113 cases of cardiovascular death, 30 cases with myocardial infarction, 49 cases with stroke, 39 cases of non-cardiovascular death, 6 cases of peripheral arterial occlusion, 55 cases with HF, and 73 cases of revascularization. A total of 365 cases had MACEs. In the multivariate Cox proportional hazard model, both sST2 and NT-proBNP were significant predictors of MACEs. Both sST2 and NT-proBNP were separately incorporated into the model with established MACE risk factors, which significantly improved the C-statistics for predicting MACEs [0.758 (0.724-0.792)] and saw an estimated net improvement in reclassification of 1.03% (P<0.001) and an integrated discrimination improvement of 0.48% (P<0.001). The Hosmer-Lemeshow test showed that the models were well calibrated with and without the two biomarkers (P>0.344 for all comparisons). Moreover, the model incorporating the two biomarkers was shown to have a better global fit than the model with only the established MACE risk factors (P<0.001). CONCLUSIONS A model incorporating sST2 and NT-proBNP was shown to outperform a model based on established MACE risk factors alone in stratifying risk of MACEs in a group of CHD patients.
OWNERSHIP STRUCTURE AND PERFORMANCE IN FAMILY BUSINESSES AT EARLY DEVELOPMENTAL STAGE: EVIDENCE FROM CHINA

This paper explores the impact of ownership structure on performance of family businesses at its early developmental stage in a context of under-developed market environment. Using a survey data of 296 private family firms in Ningbo, China, we find both management and single largest shareholder’s ownership is positively related to firm’s performance. However, family’s shareholding does not have significant impact on performance. Further inquiry on firm’s willingness to give shares to managers who are not family members indicates that while nearly half of the firms are willing to provide shares to professional managers, weak corporate governance mechanism and under-developed market may discourage such practice.
Direct identification of clinically relevant microorganisms on solid culture media by Raman spectroscopy Application

Decreasing turnaround time is a paramount objective in clinical diagnosis. We evaluated the discrimination power of Raman spectroscopy when analyzing microcolonies from nine bacterial and one yeast species directly on solid culture medium after a shortened incubation time of 6 h (compared to 24 hour for macrocolonies). This approach, that minimizes sample preparation and culture time, would allow resuming culture after identification to perform downstream antibiotic susceptibility testing.
Core field acceleration pulse as a common cause of the 2003and 2007 geomagnetic jerks

Short period variations in the Earth's rotation rate, length‐of‐day (LOD), are driven mainly by the atmosphere with smaller contributions by the oceans. Previous studies have noted a lag of atmospheric angular momentum (AAM) with LOD that would imply another source. We examine AAM from the European Centre for Medium‐Range Weather Forecasts (ECMWF) and the National Centers for Environmental Prediction (NCEP) reanalysis series, along with oceanic angular momentum (OAM) from the ECCO consortium; land hydrological effects made no discernible impact. The NCEP reanalysis together with OAM produces a significant lag with LOD, while the ECMWF reanalysis AAM with OAM shows no phase lag. We find significant coherence with LOD variations down to periods of 4 days; coherence losses at shorter periods likely arise from the inverted barometer assumption and unmodeled dynamical processes. Thus the inclusion of core effects is not needed to balance the axial angular momentum budget on sub‐seasonal time scales.
Social Contribution and Psychological Well-Being among Midlife Adults with Chronic Pain: A Longitudinal Approach

Objectives: Contributing to the welfare of others has been shown to have positive effects on people’s social and psychological well-being (PWB). The current study examined whether social contribution (SC) could alleviate the negative effects of chronic pain on PWB through perceived social support (PSS) among midlife and older adults. Methods: The study consisted of 520 participants with chronic pain from the two waves of the Midlife in the United States dataset (MIDUS II and III). Results: Results from the longitudinal moderated mediation analysis indicated that SC at Time 2 (T2) significantly buffered the negative effect of pain interference (PI) at Time 1 (T1) on PSS at T2, which indirectly alleviated the negative effect of PI at T1 on PWB at T2. Discussion: The study suggested the protective role of SC and prosocial behaviors in mitigating the detrimental effects of chronic pain on social support and PWB.
Conference on ‘ PUFA mediators : implications for human health ’ Symposium 1 : PUFA : health effects and health claims Ageing and apoE change DHA homeostasis : relevance to age-related cognitive decline

Marie Hennebelle, Mélanie Plourde, Raphaël Chouinard-Watkins, Christian-Alexandre Castellano, Pascale Barberger-Gateau and Stephen C. Cunnane* Research Center on Aging, Université de Sherbrooke, Sherbrooke, QC, Canada, Physiology and Biophysics, Université de Sherbrooke, Sherbrooke, QC, Canada, Departments of Medicine, Université de Sherbrooke, Sherbrooke, QC, Canada INSERM, ISPED, Centre INSERM U897-Epidemiologie-Biostatistique, F-33000 Bordeaux, France
The European Regional Science Association Annual Conference 2011 Abstract

This paper analyses the spatial variation of new entrepreneurial activity across 32 Scottish regions for the period 1998-2007. Entrepreneurship is widely recognised as a key determinant of economic growth, regional prosperity and sustainable development. Using data from the Value Added Tax (VAT) register, this paper estimates spatial variation in new entrepreneurial activity using a panel data model. Results show that there is considerable variation in entrepreneurship across Scottish regions and that this variation may be explained by demand and supply factors, policy and cultural factors and agglomeration benefits. Given that Scotland has recently suffered from low levels of entrepreneurship compared with other parts of the UK and similar sized smaller countries, this paper provides relevant and timely findings, as Scotland attempts to recover from the recent recession.
Strange form factors of the nucleon with a nonlocal chiral effective Lagrangian

The strange form factors of nucleon are studied with the nonlocal chiral effective Lagrangian. One loop contributions from both octet and decuplet intermediate states are included. The relativistic regulator is obtained by the nonlocal Lagrangian where the gauge link is introduced to guarantee the local gauge symmetry. With the kaon loop, the calculated charge form factor is positive, while the magnetic form factor is negative. The strange magnetic moment is $-0.041^{+0.012}_{-0.014}$ with $\Lambda=0.9 \pm 0.1$ determined from the nucleon electromagnetic form factors. Our results are comparable with the recent lattice simulation.
Clinician Perspectives and Design Implications in Using Patient-Generated Health Data to Improve Mental Health Practices: Mixed Methods Study

Background Patient-generated health data (PGHD) have been largely collected through mobile health (mHealth) apps and wearable devices. PGHD can be especially helpful in mental health, as patients’ illness history and symptom narratives are vital to developing diagnoses and treatment plans. However, the extent to which clinicians use mental health–related PGHD is unknown. Objective A mixed methods study was conducted to understand clinicians’ perspectives on PGHD and current mental health apps. This approach uses information gathered from semistructured interviews, workflow analysis, and user-written mental health app reviews to answer the following research questions: (1) What is the current workflow of mental health practice and how are PGHD integrated into this workflow, (2) what are clinicians’ perspectives on PGHD and how do they choose mobile apps for their patients, (3) and what are the features of current mobile apps in terms of interpreting and sharing PGHD? Methods The study consists of semistructured interviews with 12 psychiatrists and clinical psychologists from a large academic hospital. These interviews were thematically and qualitatively analyzed for common themes and workflow elements. User-posted reviews of 56 sleep and mood tracking apps were analyzed to understand app features in comparison with the information gathered from interviews. Results The results showed that PGHD have been part of the workflow, but its integration and use are not optimized. Mental health clinicians supported the use of PGHD but had concerns regarding data reliability and accuracy. They also identified challenges in selecting suitable apps for their patients. From the app review, it was discovered that mHealth apps had limited features to support personalization and collaborative care as well as data interpretation and sharing. Conclusions This study investigates clinicians’ perspectives on PGHD use and explored existing app features using the app review data in the mental health setting. A total of 3 design guidelines were generated: (1) improve data interpretation and sharing mechanisms, (2) consider clinical workflow and electronic health record integration, and (3) support personalized and collaborative care. More research is needed to demonstrate the best practices of PGHD use and to evaluate their effectiveness in improving patient outcomes.
Retina Grk 1 b and Grk 7 a Both Contribute to the Recovery of the Isolated Cone Photoresponse in Larval Zebrafish

Jared D. Chrispell, Enheng Dong,* Shoji Osawa, Jiandong Liu, D. Joshua Cameron, and Ellen R. Weiss Department of Cell Biology and Physiology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States Department of Pathology and Laboratory Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States College of Optometry, Western University of Health Sciences, Pomona, California, United States Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States
Relationship between Pain Profiles and Comorbidity in Elderly Population

Pain is a common complaint that are often untreated or undertreated of the elderly. Therefore, undertreatment for pain can have an impairment on the health and quality of life of the elderly, resulting in depression, anxiety, social isolation, cognitive impairment, immobility, and sleep disturbances. Geriatric patients are more likely to have arthritis, bone and joint disorders, cancer and other chronic disorders associated with pain. As the number of elderlies continues to rise, frailty and chronic disease associated with pain are expected to increase [1]. The age limit for elderly in Indonesia is 60 years or more. In 2017, the elderly population in Indonesia reaches 23,66 million people or 9,03% from the country total population. The number of people worldwide 65 years and older was estimated at 506 million as of 2008 and by 2040 will increase to 1.3 billion. The morbidity of elderly population in Indonesia is 28,62% in 2015 and will increases every year. According to the International Association for the Study of Pain, as many as 48.5% of geriatric patients come to the hospital with pain complaints [2].
Current views Adjuvant radiotherapy and chemotherapy in the treatment of rectal cancer

As regards the preoperative estimation of the bowel wall depth of invasion, digital examination accuracy is not more than 68% and the magnetic resonance imaging (MRI) reaches only 66%. The accuracy though of the endoluminal ultrasound (EUS) exceeds 88%. Those methods are less accurate when they are used to determine the regional lymph node status. The endoluminal ultrasound accuracy is not more than 71% and that of the magnetic resonance tomography is less than 72%. Combining EUS and MRI helps us to select patients with advanced rectal cancer which are candidates for preoperative adjuvant treatment. None of these techniques, however, can reliably identify the extend of lymph node involvement.
Comparing a Mobile Phone Automated System With a Paper and Email Data Collection System: Substudy Within a Randomized Controlled Trial

Background Traditional data collection methods using paper and email are increasingly being replaced by data collection using mobile phones, although there is limited evidence evaluating the impact of mobile phone technology as part of an automated research management system on data collection and health outcomes. Objective The aim of this study is to compare a web-based mobile phone automated system (MPAS) with a more traditional delivery and data collection system combining paper and email data collection (PEDC) in a cohort of breastfeeding women. Methods We conducted a substudy of a randomized controlled trial in Sydney, Australia, which included women with uncomplicated term births who intended to breastfeed. Women were recruited within 72 hours of giving birth. A quasi-randomized number of women were recruited using the PEDC system, and the remainder were recruited using the MPAS. The outcomes assessed included the effectiveness of data collection, impact on study outcomes, response rate, acceptability, and cost analysis between the MPAS and PEDC methods. Results Women were recruited between April 2015 and December 2016. The analysis included 555 women: 471 using the MPAS and 84 using the PEDC. There were no differences in clinical outcomes between the 2 groups. At the end of the 8-week treatment phase, the MPAS group showed an increased response rate compared with the PEDC group (56% vs 37%; P<.001), which was also seen at the 2-, 6-, and 12-month follow-ups. At the 2-month follow-up, the MPAS participants also showed an increased rate of self-reported treatment compliance (70% vs 56%; P<.001) and a higher recommendation rate for future use (95% vs 64%; P<.001) as compared with the PEDC group. The cost analysis between the 2 groups was comparable. Conclusions MPAS is an effective and acceptable method for improving the overall management, treatment compliance, and methodological quality of clinical research to ensure the validity and reliability of findings.
TIPP 2011-Technology and Instrumentation for Particle Physics 2011 Development of Ultra-Thin GaAs Photocathodes

An ultra thin and highly efficient photocathode structure is designed and optimized for the 400nm optical wavelength regime. The cathode thickness is comparable to the mean free path of the photoelectron allowing design concepts which are built on non-thermalized photoelectrons. Designs for ultra-low emittance and high quantum efficiency are proposed and first test structures are grown and characterized. Additionally, a discussion on the specifics of the transfer and bonding process of ultra-thin cathodes is presented. © 2011 Published by Elsevier BV. Selection and/or peer-review under responsibility of the organizing committee for TIPP 2011
Integrated Skin Transcriptomics and Serum Multiplex Assays Reveal Novel Mechanisms of Wound Healing in Diabetic Foot Ulcers

Nonhealing diabetic foot ulcers (DFUs) are characterized by low-grade chronic inflammation, both locally and systemically. We prospectively followed a group of patients who either healed or developed nonhealing chronic DFUs. Serum and forearm skin analysis, both at the protein expression and the transcriptomic level, indicated that increased expression of factors such as interferon-γ (IFN-γ), vascular endothelial growth factor, and soluble vascular cell adhesion molecule-1 were associated with DFU healing. Furthermore, foot skin single-cell RNA sequencing analysis showed multiple fibroblast cell clusters and increased inflammation in the dorsal skin of patients with diabetes mellitus (DM) and DFU specimens compared with control subjects. In addition, in myeloid cell DM and DFU upstream regulator analysis, we observed inhibition of interleukin-13 and IFN-γ and dysregulation of biological processes that included cell movement of monocytes, migration of dendritic cells, and chemotaxis of antigen-presenting cells pointing to an impaired migratory profile of immune cells in DM skin. The SLCO2A1 and CYP1A1 genes, which were upregulated at the forearm of nonhealers, were mainly expressed by the vascular endothelial cell cluster almost exclusively in DFU, indicating a potential important role in wound healing. These results from integrated protein and transcriptome analyses identified individual genes and pathways that can potentially be targeted for enhancing DFU healing.