Miracle-dz/UniFAR-FTUs huggingface dataset:
A Molecular Dynamics Study of Monomer Melt Properties of Cyanate Ester Monomer Melt Properties

The objective of this work was to computationally predict the melting temperature and melt properties of thermosetting monomers used in aerospace applications. In this study, we applied an existing voids method by Solca. to examine four cyanate ester monomers with a wide range of melting temperatures. Voids were introduced into some simulations by removal of molecules from lattice positions to lower the free-energy barrier to melting to directly simulate the transition from a stable crystal to amorphous solid and capture the melting temperature. We validated model predictions by comparing melting temperature against previously reported literature values. Additionally, the torsion and orientational order parameters were used to examine the monomers’ freedom of motion to investigate structure–property relationships. Ultimately, the voids method provided reasonable estimates of melting temperature while the torsion and order parameter analysis provided insight into sources of the differing melt properties between the thermosetting monomers. As a whole, the results shed light on how freedom of molecular motions in the monomer melt state may affect melting temperature and can be utilized to inspire the development of thermosetting monomers with optimal monomer melt properties for demanding applications.
Laser Direct Writing of Dual-Scale 3D Structures for Cell Repelling at High Cellular Density

The fabrication of complex, reproducible, and accurate micro-and nanostructured interfaces that impede the interaction between material’s surface and different cell types represents an important objective in the development of medical devices. This can be achieved by topographical means such as dual-scale structures, mainly represented by microstructures with surface nanopatterning. Fabrication via laser irradiation of materials seems promising. However, laser-assisted fabrication of dual-scale structures, i.e., ripples relies on stochastic processes deriving from laser–matter interaction, limiting the control over the structures’ topography. In this paper, we report on laser fabrication of cell-repellent dual-scale 3D structures with fully reproducible and high spatial accuracy topographies. Structures were designed as micrometric “mushrooms” decorated with fingerprint-like nanometric features with heights and periodicities close to those of the calamistrum, i.e., 200–300 nm. They were fabricated by Laser Direct Writing via Two-Photon Polymerization of IP-Dip photoresist. Design and laser writing parameters were optimized for conferring cell-repellent properties to the structures, even for high cellular densities in the culture medium. The structures were most efficient in repelling the cells when the fingerprint-like features had periodicities and heights of ≅200 nm, fairly close to the repellent surfaces of the calamistrum. Laser power was the most important parameter for the optimization protocol.
Application of Total Physical Response (TPR) in the Development of Chinese as Second Language Module

This study aims to apply the Total Physical Response (TPR) method for developing MyDialogKopitiam Module in learning Chinese Language National Primary School (Bahasa Cina Sekolah Kebangsaan BCSK) in national primary school. The TPR method combines language and body movements and has various teaching forms and rich teaching processes. Therefore, different Chinese language teachers have paid attention to it in recent years. TPR method also plays a vital role in teaching Chinese as a second language. In this paper, the authors will discuss the use of the TPR method, which consists of Game Teaching Methods, Drawing Teaching Methods, Music Teaching Methods, Simulation Teaching Methods, Movement Teaching Methods, Cardboard Teaching Methods and Mimicry Teaching Methods in developing MyDialogKopitiam Module for learning Chinese as a second language in school. This study also describes the TPR method activities carried out by teachers and students in using MyDialogKopitiam Module. The implication of this paper is to act as guidance for teachers and educators that apply the TPR method in developing a module for second language learners.
Use of Discourse Markers among Senior University Students

The study of discourse markers has attracted the attention of researchers as a facet of linguistics since the 19th century. The focus of research has been based on the theoretical status of discourse markers in relation to how they are used and for what reasons, explored in different contexts and settings; however, few studies have been conducted in the context of Saudi Arabia. This study, therefore, attempted to look at the use of discourse markers by senior university students majoring in English in Saudi Arabia and its functions. Fraser’s (2004) semantic perspective, classifying discourse markers into four categories, was adopted, together with Hiilker’s (1991) features of discourse markers, consistent with the view that the meaning of discourse markers is related to their function of clarifying the intrinsic value of an utterance. The results revealed that students in their essays employed discourse markers in all four of Fraser’s (2004) categories. However, it was evident that the participating students struggled with the appropriate use of discourse markers. This issue should be examined in greater depth and the reasons for this difficulty assessed. One reason lies in students’ low exposure to discourse markers in class. It is thus highly recommended that teachers raise EFL students’ awareness of discourse markers by providing them with more related tasks and exercises.
Early Paleozoic arc-back-arc system evolution in the junction of the Qinling and Qilian Orogens: Geochemical constraints from ca. 445–430 Ma magmatic rocks in the Tianshui area

ABSTRACT The Tianshui area is located at the junction of the Qinling and Qilian Orogens, the evolution of which is crucial in understanding the Early Palaeozoic tectonic evolution of the Central China Orogenic System. We present here geochronological, geochemical, and Sr-Nd isotopic data for four representative Silurian magmatic rocks, termed the Dangchuan, Huamiao, Yanjiadian, and Hongtupu, along a cross section across the main rock units of the Tianhui area. The 432 Ma Dangchuan syenogranites are peraluminous with negative εNd(t) values, high initial 87Sr/86Sr ratios, and low Rb/Sr and high CaO/Na2O ratios. We interpret the syenogranites to be generated by partial melting of metagreywackes during a Silurian orogenic event. The 436 Ma Huamiao diorites are high-Mg diorites with high MgO contents and Mg# (63–65) and enriched Sr-Nd isotopic compositions. The 445 Ma Yanjiadian diorites are high-Mg adakitic rocks with high Sr and Mg# and low Y and Yb contents. They were both generated by the interaction between sediment/slab-derived fluids/melts and mantle peridotite in the subduction-related setting. The 445 Ma Hongtupu basalts include E-MORB and IAB with depleted Sr-Nd isotopic compositions. They were derived from enriched mantle and sediment-modified mantle, respectively, and formed in a back-arc basin setting. Synthesizing our new and published data, we propose a tectonic model involving generation of Baihua-Huluhe arc-back-arc system, subduction of the Huluhe back-arc oceanic basin, and collision between the North Qinling arc terrane and North China Block, which is closely associated with the closure of the Proto-Tethys Ocean.
Molecular Insights into Freezing Stress in Peach Based on Multi-Omics and Biotechnology: An Overview

In nature or field conditions, plants are frequently exposed to diverse environmental stressors. Among abiotic stresses, the low temperature of freezing conditions is a critical factor that influences plants, including horticultural crops, decreasing their growth, development, and eventually quality and productivity. Fortunately, plants have developed a mechanism to improve the tolerance to freezing during exposure to a range of low temperatures. In this present review, current findings on freezing stress physiology and genetics in peach (Prunus persica) were refined with an emphasis on adaptive mechanisms for cold acclimation, deacclimation, and reacclimation. In addition, advancements using multi-omics and genetic engineering approaches unravel the molecular physiological mechanisms, including hormonal regulations and their general perceptions of freezing tolerance in peach were comprehensively described. This review might pave the way for future research to the horticulturalists and research scientists to overcome the challenges of freezing temperature and improvement of crop management in these conditions.
Serious Leisure and Passion in University Programs for Seniors

Perseverance and persistence, effort, leisure career, permanent acquisitions, specific norms, and identification with the occupation are some of the hallmarks of the serious leisure perspective. The Dualistic Model of Passion (DMP) understands passion as a strong inclination towards an activity that a person loves, considers important, and in which they invest a great amount of time and energy. This article proposes to explore these two theoretical constructs that converge in their conceptual bases, in a group of older people who regularly participate in university training programs throughout life. The sample is made up of 157 persons over 60 years old enrolled in courses for the elderly at the University of Deusto (Bilbao, Spain). The quantitative findings revealed: (1) that there are no significant differences according to sociodemographic variables, (2) that learning throughout life in the case of older people can be converted into serious leisure, and (3) that the participants in training programs for seniors develop a harmonious passion for such activity.
"I Shy Away": Student-Teachers View on Non-Selection of Physical Education As an Elective in Colleges of Education

Physical Education since its inception has been playing an essential role in student's development, particularly in early childhood. This paper, therefore, sought to examine the factors associated with the selection and non-selection of Physical Education as an elective course. With the social cognitive career theory as a lens, the findings were premised on a semi-structured interview schedule with 20 targeted student-teachers from the 8 colleges of education in the Ashanti region, Ghana. The study revealed that difficulty, lack of interest, absence of Physical Education in the curriculum, inadequate information and knowledge, and misconceptions about Physical Education underpinned its non-selection. Further, the study discovered that factors such as awareness creation, pursuance of Physical Education as an elective in Senior High School, employing practical methods, employment of additional Physical Education tutors, and health benefits attract student-teachers to select Physical Education as an elective course. The study recommended enlightenment, early education, hands-on knowledge, improved human resource, and well-being as measures to curb the issue of non-selection of Physical Education.
Evaluation of Moisture Regime on Agronomic Traits of Rice Genotypes

Drought stress is a major constraint to the production and yield stability of crops. Rice (Oryza sativa L.) is one of the most important cereals and considered as a drought sensitive crop species. A field experiment was conducted in the vinylhouse of the Department of Agronomy, Bangabandhu Sheikh Mujibur Rahman Agricultural University, Bangladesh, during March - August 2018 to evaluate the performance of 38 rice genotypes under control and drought conditions. The experiment was laid out in a completely randomized design containing two water regimes with three replications. The water regimes were well-watered and induced moisture stress conditions. Multivariate and principal components analyses revealed that different plant characters, viz. plant height, total tillers hill-1, panicle number hill-1, length of panicle, filled grains panicle-1, 1000-grain weight, grain yield plant-1 and straw weight plant-1 showed a wide range of variation due to variation in moisture level. Correlation study and biplot analysis considering PC1 and PC2 explained that grain yield was positively correlated with filled grain panicle-1, total tiller hill-1, panicle number hill-1 and 1000-grain weight. Based on the grain yield plant-1 (g) and others agronomic characters, the genotypes BU Acc 33 (26.68 g), BU Acc 30 (21.81 g), and BU Acc 21 (20.58 g) were identified as promising genotypes for developing drought tolerant variety (ies). Ann. Bangladesh Agric. (2021) 25 (1) : 89-104
Identification of Biomarker Volatile Organic Compounds Released by Three Stored-Grain Insect Pests in Wheat

Monitoring and early detection of stored-grain insect infestation is essential to implement timely and effective pest management decisions to protect stored grains. We report a reliable analytical procedure based on headspace solid-phase microextraction coupled with gas chromatography–mass spectrometry (HS-SPME-GC-MS) to assess stored-grain infestation through the detection of volatile compounds emitted by insects. Four different fibre coatings were assessed; 85 µm CAR/PDMS had optimal efficiency in the extraction of analytes from wheat. The headspace profiles of volatile compounds produced by Tribolium castaneum (Herbst), Rhyzopertha dominica (Fabricius), and Sitophilus granarius (Linnaeus), either alone or with wheat, were compared with those of non-infested wheat grains. Qualitative analysis of chromatograms showed the presence of different volatile compound profiles in wheat with pest infestation compared with the wheat controls. Wheat-specific and insect-specific volatile compounds were identified, including the aggregation pheromones, dominicalure-1 and dominicalure-2, from R. dominica, and benzoquinones homologs from T. castaneum. For the first time, the presence of 3-hydroxy-2-butanone was reported from S. granarius, which might function as an alarm pheromone. These identified candidate biomarker compounds can be utilized in insect surveillance and monitoring in stored grain to safeguard our grain products in future.
Cytokeratin Expression Pattern in Human Endometrial Carcinomas and Lymph Nodes Micrometastasis: a Mini-review

Cytokeratins (CKs) are the largest subgroup of intermediate filament proteins, preferentially expressed in epithelial tissues. CKs play a critical role in determining epithelial structural integrity under stressful conditions in addition to their various fundamental functions in cellular proliferation, apoptosis, migration, adherence and molecular signaling. Immunohistochemical CKs staining could be evaluated with a proper comprehension of their task limitations and their association with the normal morphology to avoid misdiagnosis. Herein, we critically review the CKs expression patterns in ECs in relation to clinicopathological features and patients' outcome. We also briefly discussed the recent advantage of CKs immunohistochemical staining in the detection of EC micrometastasis.
Effectiveness of Promotive and Preventive Psychosocial Interventions on Improving the Mental Health of Finnish-Born and Immigrant Adolescents

Background: Schools are considered natural environments in which to enhance students’ social–emotional skills and mental health in general, but they can be especially important for students with refugee and immigrant backgrounds. The current study tested the effectiveness of two school-based interventions in enhancing the mental health and wellbeing of adolescents of native, refugee, and immigrant backgrounds. It further analyzed the role of age, gender, daily stressors, and discrimination in affecting the interventions’ effectiveness. Methods: A three-arm cluster RCT with parallel assignment was applied among the 16 schools. Schools were randomized to three conditions of two active interventions and a waiting-list control condition. Students (n = 1974) filled in an online questionnaire at baseline before the interventions, after the interventions, and at follow-up an average of 9 months after the interventions. The effectiveness criteria were internalizing and externalizing problems, resilience, and prosocial behavior. Results: Interventions were generally not effective in decreasing mental health problems and increasing psychosocial resources. The expected positive intervention effects were dependent on students’ age and gender and exposure to socioeconomic daily stressors. Conclusion: Interventions enhancing teacher awareness and peer relationships at school should be carefully tailored according to the strengths and vulnerabilities of participating students, especially their daily stress exposure, but also age and gender.
The Prevalence of Economic Abuse Among Intimate Partners in Alberta

We examine the prevalence of economic abuse in all demographics. Previous research primarily considers female victims within heterosexual relationships characterized by other forms of intimate partner violence (“IPV”). Consequently, economic abuse may appear to be a less widespread societal issue than it is. Relying on theory that IPV is not a gendered phenomenon, we collected primary data of the prevalence of economic abuse in the Alberta general population and analyzed the influence of demographic variables on the likelihood of experiencing economic abuse. We surveyed 300 random adults in every demographic on what economically abusive behaviors they have experienced and used univariate and regression analysis to determine the effect of different demographic variables on those experiences. We found that 36% of all adults in the sample experienced economic abuse, with 17% experiencing severe economic abuse. Being male or female had no statistical impact on the likelihood of experiencing such abuse, and the effect of income is contrary to previous assumptions. Women are more vulnerable to Economic Control, a subtype of economic abuse. Economic abuse is a broader problem than research to date has considered. Though it is not a gendered phenomenon, different behaviors are more prevalent or severe for different genders. The prevalence of economic abuse in all demographics suggests that further awareness and advocacy is necessary to reduce its incidence. Additional research on a national level is needed to determine patterns and motivations for economic abuse and its correlations with other forms of IPV.
Immunophenotypic Analysis of Acute Megakaryoblastic Leukemia: A EuroFlow Study

Simple Summary Acute megakaryoblastic leukemia (AMKL) is a rare and heterogeneous subtype of acute myeloid leukemia (AML). We show that such patients can be identified by flowcytometric immunophenotyping using the standardized EuroFlow panel. AMKL patients show a unique immunophenotypic profile, and among AMKL patients, various subgroups can be distinguished. Abstract Acute megakaryoblastic leukemia (AMKL) is a rare and heterogeneous subtype of acute myeloid leukemia (AML). We evaluated the immunophenotypic profile of 72 AMKL and 114 non-AMKL AML patients using the EuroFlow AML panel. Univariate and multivariate/multidimensional analyses were performed to identify most relevant markers contributing to the diagnosis of AMKL. AMKL patients were subdivided into transient abnormal myelopoiesis (TAM), myeloid leukemia associated with Down syndrome (ML-DS), AML—not otherwise specified with megakaryocytic differentiation (NOS-AMKL), and AMKL—other patients (AML patients with other WHO classification but with flowcytometric features of megakaryocytic differentiation). Flowcytometric analysis showed good discrimination between AMKL and non-AMKL patients based on differential expression of, in particular, CD42a.CD61, CD41, CD42b, HLADR, CD15 and CD13. Combining CD42a.CD61 (positive) and CD13 (negative) resulted in a sensitivity of 71% and a specificity of 99%. Within AMKL patients, TAM and ML-DS patients showed higher frequencies of immature CD34+/CD117+ leukemic cells as compared to NOS-AMKL and AMKL-Other patients. In addition, ML-DS patients showed a significantly higher expression of CD33, CD11b, CD38 and CD7 as compared to the other three subgroups, allowing for good distinction of these patients. Overall, our data show that the EuroFlow AML panel allows for straightforward diagnosis of AMKL and that ML-DS is associated with a unique immunophenotypic profile.
The Effect of the COVID-19 Pandemic on Pediatric Physician Wellness: A Cross-Sectional Study

The COVID-19 pandemic has provided challenges to all healthcare workers. While the brunt of treating COVID-19 patients fell upon adult providers, pediatricians also experienced significant stressors and disruptions. Academic pediatricians and trainees (fellows and residents) were redeployed to manage adult patients in hospitalist and intensive care settings and/or had major changes to their clinical schedules. In this study, we aimed to describe levels of self-reported depression, anxiety, and burnout in pediatric physicians following the initial wave of the pandemic at the largest integrated health system in New York State. A cross-sectional study was conducted among pediatric physicians who cared for patients during the COVID-19 pandemic within the Northwell Health System as part of the Northwell Wellbeing Registry, a longitudinal registry assessing the psychological impact of COVID-19 on healthcare providers. A total of 99 pediatric physician respondents were included in this study; 72% of whom were attendings, 28% of whom were trainees. Compared to attendings, trainees reported significantly higher proportions of burnout–emotional exhaustion (p = 0.0007) and burnout–depersonalization (p = 0.0011) on the Abbreviated Maslach Burnout Inventory. There was not a similar trend in probable depression or probable anxiety using the Patient Health Questionnaire. In a multivariable logistic regression model, being a trainee was significantly associated with increased odds of burnout–emotional exhaustion (OR 5.94, 95% Confidence Interval: 1.85–19.02). These findings suggest that fellows and residents were a vulnerable population during the COVID-19 pandemic. Training programs should pay special attention to their trainees during times of crisis, and future studies can help to identify protective factors to reduce the risk of burnout during these times.
MicroRNA Cross-Involvement in Acne Vulgaris and Hidradenitis Suppurativa: A Literature Review

Acne Vulgaris (AV) and Hidradenitis suppurativa (HS) are common chronic inflammatory skin conditions that affect the follicular units that often coexist or are involved in differential diagnoses. Inflammation in both these diseases may result from shared pathways, which may partially explain their frequent coexistence. MicroRNAs (miRNAs) are a class of endogenous, short, non-protein coding, gene-silencing or promoting RNAs that may promote various inflammatory diseases. This narrative review investigates the current knowledge regarding miRNAs and their link to AV and HS. The aim is to examine the role of these molecules in the pathogenesis of AV and HS and to identify possible common miRNAs that could explain the similar characteristics of these two diseases. Five miRNA (miR-155 miR-223-, miR-21, and miRNA-146a) levels were found to be altered in both HS and AV. These miRNAs are related to pathogenetic aspects common to both pathologies, such as the regulation of the innate immune response, regulation of the Th1/Th17 axis, and fibrosis processes that induce scar formation. This review provides a starting point for further studies aimed at investigating the role of miRNAs in AV and HS for their possible use as diagnostic-therapeutic targets.