Miracle-dz/UniFAR-FTUs huggingface dataset:
Metal Complexes or Chelators with ROS Regulation Capacity: Promising Candidates for Cancer Treatment

Reactive oxygen species (ROS) are rapidly eliminated and reproduced in organisms, and they always play important roles in various biological functions and abnormal pathological processes. Evaluated ROS have frequently been observed in various cancers to activate multiple pro-tumorigenic signaling pathways and induce the survival and proliferation of cancer cells. Hydrogen peroxide (H2O2) and superoxide anion (O2•−) are the most important redox signaling agents in cancer cells, the homeostasis of which is maintained by dozens of growth factors, cytokines, and antioxidant enzymes. Therefore, antioxidant enzymes tend to have higher activity levels to maintain the homeostasis of ROS in cancer cells. Effective intervention in the ROS homeostasis of cancer cells by chelating agents or metal complexes has already developed into an important anti-cancer strategy. We can inhibit the activity of antioxidant enzymes using chelators or metal complexes; on the other hand, we can also use metal complexes to directly regulate the level of ROS in cancer cells via mitochondria. In this review, metal complexes or chelators with ROS regulation capacity and with anti-cancer applications are collectively and comprehensively analyzed, which is beneficial for the development of the next generation of inorganic anti-cancer drugs based on ROS regulation. We expect that this review will provide a new perspective to develop novel inorganic reagents for killing cancer cells and, further, as candidates or clinical drugs.
Sensorless Passivity Based Control of a DC Motor via a Solar Powered Sepic Converter-Full Bridge Combination

This article deals with the sensor-less control of a DC Motor via a SEPIC Converter-Full Bridge combination powered through solar panels. We simultaneously regulate, both, the output voltage of the SEPIC-converter to a value larger than the solar panel output voltage, and the shaft angular velocity, in any of the turning senses, so that it tracks a pre-specified constant reference. The main result of our proposed control scheme is an efficient linear controller obtained via Lyapunov. This controller is based on measurements of the converter currents and voltages, and the DC motor armature current. The control law is derived using an exact stabilization error dynamics model, from which a static linear passive feedback control law is derived. All values of the constant references are parameterized in terms of the equilibrium point of the multivariable system: the SEPIC converter desired output voltage, the solar panel output voltage at its Maximun Power Point (MPP), and the DC motor desired constant angular velocity. The switched control realization of the designed average continuous feedback control law is accomplished by means of a, discrete-valued, Pulse Width Modulation (PWM). Experimental results are presented demonstrating the viability of our proposal.
Multi‐objective optimization and decision‐making of the combined control law of guide vane and pressure regulating valve for hydroelectric unit

This paper aimed to investigate the multi‐objective optimization and decision‐making of the combined control law of guide vane (CCLGV) and pressure regulating valve (PRV) for hydroelectric unit under load rejection. Firstly, the multi‐objective optimization problem of CCLGV‐PRV is formulated. Then, a new multi‐objective gravitation search algorithm with non‐dominated screening and chaos mutation (NCMOGSA) is adopted to solve it. Moreover, an improved entropy weight method and relative objective proximity method are applied to select suitable solution. Finally, a comprehensive comparative study is carried out to reveal the mechanism between the CCLGV‐PRV and several basic parameters. The results indicate that replacing surge tank with PRV can effectively solve the contradictory between water pressure at the bottom of volute and rotational speed under load rejection. The NCMOGSA shows excellent performance in solving the multi‐objective optimization problem of CCLGV‐PRV and get a group of Pareto set. The improved entropy weight and relative objective proximity method make the final scheme clear. The rise rate of rotational speed is completely determined by the guide vane (GV), and the water pressure is jointly determined by the control law of the GV and PRV. The two‐stage closing and two‐stage opening (TCTO) is the final recommendation for CCLGV‐PRV.
Understanding the Role of Communication in the Management Accounting and Control Process

Too kaitsmine toimub Tamperes, Ulle Parl saab nii Tampere kui ka Tartu Ulikooli kraadi. Vaitekirja elektrooniline versioon on voetud Tampere Ulikooli kodulehelt: http://acta.uta. fi/english/teos.php? id=1000172
Videojuegos y educación: análisis de tendencias en investigación

Mucho se ha escrito en los últimos tiempos acerca de las posibilidades y controversias del uso de los videojuegos en educación. Para conocer las tendencias en investigación, a través de la productividad, impacto, colaboración y difusión, se realizó un análisis bibliométrico sobre 226 documentos disponibles en la base de datos Scopus. Además, se complementó con un análisis de contenido de los 62 artículos disponibles en acceso abierto. Los resultados muestran el interés por el estudio de esta cuestión y el auge en la última década, el peso de países como España, y el elevado impacto de casi la mitad de los artículos. Además, se confirma lo esperado según la Ley de Lotka y Bradford. Las investigaciones confirman que los videojuegos tienen efectos positivos en el aprendizaje, la motivación y la dinámica de la clase, sin olvidar el papel fundamental del profesorado, el diseño y la finalidad del propio juego. Por último, se señalan futuras líneas de investigación vinculadas a la necesaria formación del profesorado o la evaluación de los videojuegos desde una vertiente pedagógica.
Measurement of a DSB modulated RF signal by use of discriminating filters and envelope detection

This paper proposes a method to measure the amplitude and the phase of the spectral tones present in both sidebands of a microwave amplitude modulated RF signal. The method exploits once more the phase conservation property inherent to the frequency down conversion operation performed by an envelope detection circuit while a pair of filters bring the needed discrimination on the side-tones.
An evidence-based approach in the management of fatigue due to heart failure: breathing exercises

Fatigue is one of the common symptoms that adversely affect the quality of life of patients with heart failure. It has been reported that fatigue seen in heart failure is caused by conditions such as deterioration of peripheral circulation due to decrease in oxygen delivery, autonomic nervous system abnormalities and deterioration in the strength of the respiratory muscles. Breathing exercises are one of the integrative applications that can increase oxygen delivery due to the functional connection of the heart and lungs providing relief from fatigue. In the literature, breathing exercises have a wide range of breathing techniques that create changes in breathing form and rate. Many studies have found that breathing exercises reduce fatigue, and can have significant effects on patient care and clinical outcomes. Nurses have a major impact on patient outcomes such as reducing fatigue in heart failure patients and improving health-related quality of life. For this reason, it is very important to include breathing exercises in nursing practices. In this regard, the importance of breathing exercises in the management of fatigue due to heart failure has been addressed in this review.
Activityscape Mapping: Consumer Activity Systems as Service Context

Activity systems are the cognitively linked groups of activities that consumers carry out as a part of their daily life. The aim of this paper is to investigate how consumers experience value through their activities, and how services fit into the context of activity systems. A new technique for illustrating consumers’ activity systems is introduced. The technique consists of identifying a consumer’s activities through an interview, then quantitatively measuring how the consumer evaluates the identified activities on three dimensions: Experienced benefits, sacrifices and frequency. This information is used to create a graphical representation of the consumer’s activity system, an “activityscape map”. Activity systems work as infrastructure for the individual consumer’s value experience. The paper contributes to value and service literature, where there currently are no clearly described standardized techniques for visually mapping out individual consumer activity. Existing approaches are service- or relationship focused, and are mostly used to identify activities, not to understand them. The activityscape representation provides an overview of consumers’ perceptions of their activity patterns and the position of one or several services in this pattern. Comparing different consumers’ activityscapes, it shows the differences between consumers' activity structures, and provides insight into how services are used to create value within them. The paper is conceptual; an empirical illustration is used to indicate the potential in further empirical studies. The technique can be used by businesses to understand contexts for service use, which may uncover potential for business reconfiguration and customer segmentation.
Students’ perceptions of the entrepreneurial culture in Finnish higher education institutions

The purpose of this study is to add to the literature on entrepreneurial universities by investigating entrepreneurial culture (EC) in higher education institutions (HEIs). The authors investigate how students experience EC and which factors explain their perceptions of EC. The study is based on a survey of HEI students in Finland with 1277 responses. The results show that formal institutional support and institution-level activities have the strongest impact on the students’ experienced EC. According to the findings, formal institutional support has a greater impact on students’ perceptions of EC than student-driven activities. Furthermore, the results highlight that the encouragement of teachers has a greater influence on students’ perceptions of EC than peer students and student-driven activities. Accordingly, the paper’s theoretical contribution to the literature lies in its demonstration that institutional support, in addition to the encouragement of teachers, influences HEI students’ perceptions of EC. With regard to practical implications, the findings indicate that, if HEIs wish to build an EC and operate entrepreneurially, it is vital to support teachers’ entrepreneurial behaviour and thinking. In addition, equal emphasis needs to be placed on the observable artefacts and on clear, well-communicated organisational structures and processes.
Vibration Characteristics of Sandwich Beams Partially and Fully Treated with Electro-Rheological Fluid

This experimental study investigated the vibrational properties of a sandwiched beam clamped at both ends and fully or partially treated with an electro-rheological (ER) fluid layer. Frequency response function curves were obtained and analysed in the frequency range between 10 to 1000 Hz. Three factors were investigated for its effect on the ER sandwich beam system, i.e., electric field strength, length of the ER fluid layer and applied excitation gain. It was found that the electric field strength has little effect on loss factors and resonant frequencies of the fully treated beam, except for reduced vibration in some off-resonance regions. For the partially treated beam, the length of the ER fluid layer has a significant effect on resonant frequencies, but little effect on loss factors. As the length of the ER fluid layer increases, the resonant frequencies become higher in the entire frequency range considered. It was also observed that both partially and fully treated ER sandwich beams are almost linear systems, i.e., when different excitation gain levels are applied to the beams, the frequency response function curves are unchanged.
Physiological aspects of cardiopulmonary dysanapsis on exercise in adults born preterm

Progressive improvements in perinatal care and respiratory management of preterm infants have resulted in increased survival of newborns of extremely low gestational age over the past few decades. However, the incidence of bronchopulmonary dysplasia, the chronic lung disease after preterm birth, has not changed. Studies of the long‐term follow‐up of adults born preterm have shown persistent abnormalities of respiratory, cardiovascular and cardiopulmonary function, possibly leading to a lower exercise capacity. The underlying causes of these abnormalities are incompletely known, but we hypothesize that dysanapsis, i.e. discordant growth and development, in the respiratory and cardiovascular systems is a central structural feature that leads to a lower exercise capacity in young adults born preterm than those born at term. We discuss how the hypothesized system dysanapsis underscores the observed respiratory, cardiovascular and cardiopulmonary limitations. Specifically, adults born preterm have: (1) normal lung volumes but smaller airways, which causes expiratory airflow limitation and abnormal respiratory mechanics but without impacts on pulmonary gas exchange efficiency; (2) normal total cardiac size but smaller cardiac chambers; and (3) in some cases, evidence of pulmonary hypertension, particularly during exercise, suggesting a reduced pulmonary vascular capacity despite reduced cardiac output. We speculate that these underlying developmental abnormalities may accelerate the normal age‐associated decline in exercise capacity, via an accelerated decline in respiratory, cardiovascular and cardiopulmonary function. Finally, we suggest areas of future research, especially the need for longitudinal and interventional studies from infancy into adulthood to better understand how preterm birth alters exercise capacity across the lifespan.
Optimal Sensor Placement for Underwater Target Positioning with Noisy Range Measurements

Abstract Autonomous underwater vehicles (AUVs) are becoming ubiquitous due in part to the flexibility and versatility that a number of them display in the execution of individual and cooperative tasks. These characteristics, coupled with the fact that their use avoids placing human lives at risk, makes them quite attractive in a number of missions. Central to the operation of some classes of AUVs is the availability of a good underwater positioning system to localize one or more vehicles simultaneously based on information received on-board a support ship or an autonomous surface system. Speaking in loose terms, we are interested in determining the optimal geometric configuration of a surface sensor network that will, in a well defined sense, maximize the range-related information available for underwater target positioning. To this effect, we assume that the range measurements are corrupted by white Gaussian noise, the variance of which is distance-dependent. The Fisher Information Matrix and the maximization of its determinant are used to determine the sensor configuration that yields the most accurate positioning of the target. An explicit analytical result is first obtained for a three sensor network and then extended to a generic “n„ sensor network. It is shown that the optimal configuration lends itself to an interesting geometrical interpretation and that the “spreading„ of the configuration depends directly on the intensity of the range measurement noise and the target depth. Simulation examples illustrate the key results derived.
Prediction of User Acceptance and Adoption of Smart Phone for Learning with Technology Acceptance Model

This study examines how the Technology Acceptance Model (TAM) can be used as a practical tool for early user acceptance and adoption of testing mobile communication devices for learning by evaluating the relationships among perceived usefulness, perceived ease of use, attitude towards using, behavioural intentions to use and actual use. In the study, 60 potential users were presented with an introductory demonstration of smart phone for a digital systems course. Following the demonstration, data on user perceptions and attitudes about smart phones were gathered based on this initial exposure. Subjects with prior experience using the smart phones were eliminated from further analysis resulting in a final sample of 40 users. Hierarchical multiple regression was used to assess the overall model and influence of each variable of interest in determining actual use of smart phone. The analysis showed that both the user perceptions and attitudes have significant positive effects on behavioural intention and actual use of smart phone. Implications of these findings for practice and research are examined.
A Study of Interracial Differences in Turnover Intentions: The Mitigating Role of Pro-Diversity and Justice-Oriented Management

Enhancing racial justice, equity, diversity, and inclusion are the core values of public administration and critical to the functions of public-sector strategic human resources management. However, very limited empirical research has delved into the interracial differences in public sector employees’ turnover intentions and its mitigating factors. Using the 2006–2017 Federal Employee Viewpoint Survey data, the present study aims to contribute toward filling this gap in the literature. The theoretical arguments and empirical findings of this study show that when compared with White employees, Federal Black, Indigenous, and Employees of Color (BIEOC) are significantly more likely to intend to leave their current organizations. However, the likelihood of turnover intentions of Federal employees, particularly, BIEOC can be reduced through institutional interventions anchored in pro-diversity management (e.g., commitment to fostering a racially representative workforce), distributive justice in employment outcomes (e.g., in pay and promotions) and procedural justice in organizational processes (e.g., anti-discrimination practices).
Hydatid Cyst Among Patients Attending Al-Jamhoory Teaching Hospital in Mosul, Epidemiology and Clinical Profile

Background: Hydatid disease is a zoonosis induced by Echinococcus tapeworms. Humans are infected by ingestion of Echinococcus eggs by eating contaminated food. Objective: To Investigate the epidemiology of hydatid cyst first and final diagnosis in patients find out its clinical profile. Method: The current study is a Case-series retrospective study for the patients attending Al-jamhoory Teaching Hospital between January 1, 2019, and July 1, 2021. The information was gathered from medical records. The data were analyzed using the frequency index, relative frequency and SPSS (Statistical Package for the Social Sciences). Results: One-hundred eleven patients underwent during the study period. Sixty-three percent of them were males. unemployment state was 81.98%. The commonest ages of infection were 41-50 years as constitute 38.73%. About Fifty-nine percent of the patients were affected in the liver and about four percent of the patients were injured in the lungs. Villagers made up 57.65% of the patients. We found a total of (65.76%) patients had cats or dogs at home. The diagnosis of hydatid infection by Ultrasound of abdomen, Chest Xray, and CT of the chest were (47.74%), (42.34%) and (9.9%) respectively. About Ninety percent of patients eat at restaurants on a regular basis. About Twenty-eight percent of patients have a hydatid cyst in their family. Conclusion: The study indicate that diagnostic instruments are fundamental in diagnosis of hydatid as its diagnosis through clinical or preclinical are uncertain. Further education program is recommended to decrease its occurrence in Mosul city.
Development of a wideband compact leaky wave cavity antenna

As operating frequencies decrease, the aperture size of leaky wave antennas increases significantly – rendering them unsuitable for many sophisticated applications requiring small-sized communication antennas. In this article, a compact leaky wave cavity antenna with wide impedance bandwidth, using tapered cavity with substrate integrated waveguide is proposed. The antenna consists of a substrate and a rectangular metallic cavity fed by an L-shaped feed element. The metallic strips are placed along the sides of the substrate to fabricate a substrate integrated waveguide. The cavity is tapered to steer the beam in the desired direction. The tapering of the cavity causes the placement of the L-shaped feed element near the back wall of the cavity, producing input impedance mismatching. This problem of input impedance mismatching is resolved by the substrate integrated waveguide. It is demonstrated that the proposed antenna is compact (2λ0), and is wideband with voltage standing wave ratio (VSWR) bandwidth of 24% for 2:1 VSWR and a gain of 8.4 dBi. The experimental results for the designed antenna are in close agreement with the simulation results. The proposed antenna can be utilized in different wireless applications such as mobile communications, road vehicle communications and other applications.
Analytical Solution of Stationary Coupled Thermoelasticity Problem for Inhomogeneous Structures

A mathematical statement for the coupled stationary thermoelasticity is given on the basis of a variational approach and the contact boundary problem is formulated to consider inhomogeneous materials. The structure of general representation of the solution from the set of the auxiliary potentials is established. The potentials are analyzed depending on the parameters of the model, taking into account the restrictions associated with additional requirements for the positive definiteness of the potential energy density for the coupled problem in the one-dimensional case. The novelty of this work lies in the fact that it attempts to take into account the effects of higher order coupling between the gradients of the temperature fields and the gradients of the deformation fields. From a mathematical point of view, this leads to a change in the roots of the characteristic equation and affects the structure of the solution. Contact boundary value problems are formulated for modeling inhomogeneous materials and a solution for a layered structure is constructed. The analysis of the influence of the model parameters on the structure of the solution is given. The features of the distribution of mechanical and thermal fields in the region of phase contact with a change in the parameters, which are characteristic only for gradient theories of coupled thermoelasticity and stationary thermal conductivity, are discussed. It is shown, for example, that taking into account the additional parameter of connectivity of gradient fields of deformations and temperatures predicts the appearance of rapidly changing temperature fields and significant localization of heat fluxes in the vicinity of phase contact in inhomogeneous materials.