Miracle-dz/UniFAR-FTUs huggingface dataset:
Physicochemical, antioxidant and antimicrobial properties of citrus peel essential oils

Essential oils are produced as secondary metabolites of aromatic plants and can be extracted from leaves, seeds or fruit peel of the plants. Citrus peel is a rich source of limonene which is antimicrobial in nature. The present study aimed to deal with the physicochemical, antioxidant and antimicrobial properties of citrus peel essential oil from Citrus reticulate (mandarin orange), Citrus limetta (mosambi) and Citrus limon (lemon). The lemon peel oil had lower peroxide value (1.6 meq/kg of sample), saponification value (112.2 mg KOH/g of oil) and higher iodine value (116 gI2/100g oil) when compared with orange and mosambi peel essential oil. DPPH (2,2-diphenyl-1-picrylhydrazyl) free radical scavenging activity of citrus peel essential oil was measured and the result indicated that the total antioxidant activity of lemon peel oil was 89.2 % Radical Scavenging activity (RSA). The antifungal activity was assessed by agar dilution method, whereas the antibacterial property was assessed by the agar diffusion method. Lemon peel oil recorded better antimicrobial properties with minimum inhibitory concentration of 0.3% against Aspergillus flavus MTCC 277, 0.2% for Penicillium MTCC 1995 and Fusarium oxysporum MTCC 284. Likewise, the minimum inhibitory concentration of lemon peel oil against Staphylococcus aureus MTCC 96 was 0.3%; Salmonella enterica MTCC 733 and Erwinia sp MTCC 2760 was 0.5%; Pseudomonas aeruginosa MTCC 1688 and Escherichia coli MTCC 443 was 0.7%. This comparative study showed that lemon peel oil had better physicochemical and antioxidant property. Lemon peel oil can be used as a preservative in the food system as it exhibited antibacterial and antifungal activity.
Experimental Investigation on Mechanical Properties of Glass Fiber Hybridized Natural Fiber Reinforced Penta-Layered Hybrid Polymer Composite

This article investigates and presents the upshots observed in the brook of hybrid composites especially, the current investigation focuses on the impact of fiber composition, sequence, and stacking pattern on composite mechanical Features. Five varied stacking sequences of hybrid composites encompassing laminates are used to create four classes of fiber with jute/bamboo/glass by utilizing a conscientious hand lay-up process with glass fiber-laced mats as their peripheral layer. For examination, fiber sequences are arranged in the combination of GJBJG, GBJBG, GJGJG, and GBGBG, where G, J, and B refer to glass fiber, jute fiber, and bamboo fiber, respectively. The position of fiber in the core layer is kept in a perpendicular direction with respect to adjacent piles which might be jute or bamboo fiber and the best position of fiber is considered due to the stacking order. Stress and strain were linear in the load versus deflection curves, and all of the samples failed quickly, it is observed that the sample containing a higher or considerable number of bamboo fiber layers exhibited increased strain and toughness. In comparison to other samples, embolism of glass fiber as the main and covering layer expressed a higher impact on the mechanical properties of the composites is observed in this investigation. The shattered sample morphology demonstrated that the matrix and reinforcements were compatible.
Microbiome modulation in the prevention and management of colorectal cancer: a systematic review of clinical interventions

Introduction The role of probiotics/prebiotics in modulating the procarcinogenic effects of microbiota have been studied with inconclusive results. This systematic review aimed to identify the role of several studied interventions on the gut microbiota modulation in humans for the prevention and management of colorectal cancer (CRC). Methods We conducted a systematic search using PubMed and Cochrane Central electronic databases, identifying clinical studies published within the last 20 years. We performed a qualitative analysis of eligible studies included in our review on each of the 4 investigated topics: CRC potential biomarkers, dietary interventions, probiotic administration in non-surgical and surgical patients, respectively. Results A total of 54 studies involving healthy volunteers, in addition to colorectal adenoma and CRC patients were included in our qualitative synthesis. We were able to identify bacterial signatures of CRC including Fusobacterium nucleatum and Clostridium butyricum. Moreover, dietary supplementation with oligosaccharides or fibers increased short chain fatty acid-producing bacteria levels, thus inhibiting tumorigenesis. Furthermore, we have confirmed that Lactobacilli and Bifidobacterium intake modulates gut microbiota towards tumor suppression. We have also showed that probiotic intake around colectomy significantly reduces complications. Conclusions Bacterial metabolism is strongly linked with colonic carcinogenesis and influenced by diet. Probiotics and prebiotics can act as microbiota modulators, suppressing epithelial proliferation and reversing DNA toxicity. As adjuvants to surgery or chemotherapy, Lactobacilli and Bifidobacteria decrease complications. Improved outcomes in CRC patients can possibly be achieved through future research directed towards the benefits of bacterial agents as tumor suppressors or as treatment of oncological therapy resistance.
Tokyo 2020: A Sociodemographic and Psychosocial Characterization of the Portuguese Paralympic Team

The importance of practicing sports and its impact on the quality of life of people with disabilities is fundamental. Characterizing subjective well-being, resilience, and social influence in the practice of adapted sports, namely in those who participate in elite sport in Portugal, is truly important to support a set of initiatives to promote higher levels of practice. Thus, this study describes the Portuguese delegation at the Tokyo 2020 Paralympic Games through sociodemographic and psychosocial (positive and negative affect, life satisfaction, resilience, and social support) variables. The study involved 31 of the 33 athletes of the Portuguese Paralympic team aged between 15 and 58 years (34.45 ± 11.7 years), with 21 men and 10 women. Individual-level sociodemographic data gave us a clear insight into the reality of adapted sport in Portugal. The high values of life satisfaction, high positive affect and low negative affect, as well as high levels of resilience and social support seem to be important variables for these athletes. The data from the present study highlighted the importance of understanding the characteristics of Paralympic athletes, in order to better understand the reality of Paralympic sport in Portugal.
Usefulness of ß-d-Glucan Assay for the First-Line Diagnosis of Pneumocystis Pneumonia and for Discriminating between Pneumocystis Colonization and Pneumocystis Pneumonia

According to the immunodepression status, the diagnosis of Pneumocystis jirovecii pneumonia (PjP) may be difficult. Molecular methods appear very sensitive, but they lack specificity because Pj DNA can be detected in Pneumocystis-colonized patients. The aim of this study was to evaluate the value of a serum ß-d-Glucan (BDG) assay for the diagnosis of PjP in a large cohort of HIV-negative and HIV-positive patients, either as a first-line diagnostic test for PjP or as a tool to distinguish between colonization and PjP in cases of low fungal load. Data of Pj qPCR performed on bronchopulmonary specimens over a 3-year period were retrieved retrospectively. For each result, we searched for a BDG serum assay performed within ±5 days. Among the 69 episodes that occurred in HIV-positive patients and the 609 episodes that occurred in immunocompromised HIV-negative patients, we find an equivalent sensitivity of BDG assays compared with molecular methods to diagnose probable/proven PjP, in a first-line strategy. Furthermore, BDG assay can be used confidently to distinguish between infected and colonized patients using a 80 pg/mL cut-off. Finally, it is necessary to search for causes of false positivity to increase BDG assay performance. BDG assay represents a valuable adjunctive tool to distinguish between colonization and infection.
Factors associated with the low birth weight of children under five years in North Center of Burkina Faso

Introduction. Low birth weight (LBW) is a major public health problem, in both developed and developing countries, due to its magnitude and strong association with infant morbidity and mortality. Aim. To estimate the prevalence of low birth weight and identify associated factors in children under five years old. Methods. This is a cross-sectional study carried out in 8 villages in the commune of Pissila in north-central Burkina Faso, involving 262 mother-child pairs. The factors associated with low birth weight were identified according to the odds ratio (OR) raw and the 95% confidence interval (95% CI) in the bivariate analysis and according to the adjusted OR in the multivariate analysis. Sociodemographic characteristics, reproductive history, previous morbidity and factors related to prenatal care were studied. Results. A total of 262 children with birth weights based on official documents were involved in this study. The proportion of low birth weight children was estimated at 10.7%. For maternal factors, we observed that the low level of education (adjusted OR=2.6), the fact of carrying out an itinerant activity (adjusted OR=3.4) and rural socialization (adjusted OR=0.3) were significantly associated with low birth weight. Additionally, maternal parity (adjusted OR=5.5) and large household size (adjusted OR=15.0) were also associated with low birth weight. Conclusion. These results confirm the conclusions of previous studies. Family planning, pre-conception intervention, financial empowerment of women and maternal education should be strengthened to reduce the incidence of low birth weight.
Phosphorus Speciation in the Coastal Sediments of Khawr Ash Shaibah Al- Masdudah: Coastal Lagoon in the Eastern Red Sea, Kingdom of Saudi Arabia

The total phosphorus concentrations and its speciation were studied in the surface sediment of Khawr ash Shaibah al Maftuhah. The distribution pattern of total phosphorus in the sediment showed east-west gradient indicating different depositional environment of the lagoon. The largest pool of the sedimentary phosphorus was apatitic phosphorus (57%) followed by refractory organic phosphorus (42%). The impact of loosely adsorbed and exchangeable phosphorus (0.9 % of total phosphorus) and Metal oxide Phosphorus (0.6 % of total phosphorus) on the budget of total phosphorus in the sediments was minor. The concentration of dissolved phosphorus in the upper water column is most probably buffered by apatitic phosphorus. The low concentration of metal oxide phosphorus is suggested to be influenced by the calcareous nature of the lagoon. Possible transformation between apatitic and refractory organic phosphorus is inferred from the correlation of both parameters. The correlation of refractory organic carbon with total phosphorus in the sediments suggests in situ production due to biological activities.
MicroRNA Expression Profiles Analysis in Sperm Reveals hsa-mir-191 is an Auspicious Omen of in Vitro Fertilization

Background: MicroRNAs(miRNAs) are a class of non-coding small RNAs, which play important roles in many physiological processes by regulating gene expression. Previously studies show that the expression level of total miRNAs increased during the progression of mouse embryonic development, and some miRNAs control the regulatory network in the development progression. However, there are few studies focused on effects of miRNA on the early human embryonic development. The relationship of between miRNAs and early human embryogenesis is still unknown. In this study, 102 male sperm samples that were treated with assisted reproductive technology but with normal sperm index were collected for small RNA sequencing, and the relationships between differentially expressed small RNA and fertilization rate, blastocyst rate and high-quality embryo rate were analyzed. The results showed that the sperm samples with high expression of hsa-mir-191 had higher fertilization rate, blastocyst rate and high-quality embryo rate. Using hsa-mir-191 as a single indicator to predict high-quality embryo rate, the ROC curve has an AUC of 0.686. At the same time, we also found that the expression of hsa-mir-191 has a certain correlation with sperm abnormality rate (cor = 0.29, p< 0.01). In addition, we also evaluated the relationship between hsa-mir-34c and human early embryo development in these 102 sperm samples, and obtained negative results. These findings suggest that higher hsa-mir-191-5p expression with better human early embryonic development, and indicate that the hsa-mir-191-5p could be a potential marker to access the quality of IVF. between hsa-mir–191–5p and sperm routine parameters We investigated the correlation between hsa-mir–191–5p and 3 sperm routine parameters: sperm density, sperm morphology and sperm viability. The results showed that the correlation between hsa-mir–191–5p and sperm density as well as sperm viability was not significant (Figure 4A and C, p > 0.05), while the correlation between hsa-mir–191–5p and sperm morphology was significant (Figure 4B, p < 0.01), but the correlation coefficient was only 0.29, indicating a weak correlation between them. As was shown above, hsa-mir–191–5p may be one of the key molecules to maintain normal in human sperm on early embryo development reported. In the present study, we demonstrate that there is no difference in the expression of human hsa-mir–34c between different FR, EER and HQER groups, and there was no strong correlation between the amount of expression and sperm routine parameters. This us more inclined that hsa-mir–34c in human sperm is not indispensable in early embryonic development. hsa-mir–191–5p vitro fertilization and HQER EER and HQER, hsa-mir–191–5p IVF and embryonic development, and key role in maintain normal sperm morphology. All these results that hsa-mir–191–5p would be a potential biomarker to improve the success rate of IVF.
NDT_A_241497 1265..1278

Maryam Sabetghadam Mehrdokht Mazdeh Parnaz Abolfathi Younes Mohammadi 3 Maryam Mehrpooya 1 1Department of Clinical Pharmacy, School of Pharmacy, Medicinal Plants and Natural Products Research Center, Hamadan University of Medical Sciences, Hamadan, Iran; 2Department of Neurology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran; 3Modeling of Noncommunicable Diseases Research Center, School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran Purpose: Numerous preclinical studies have demonstrated the potential neuroprotective effects of N-acetylcysteine (NAC) in the treatment of brain ischemia. Accordingly, the present study aimed to assess the potential therapeutic effects of oral NAC in patients with acute ischemic stroke. Patients and Methods: In a randomized, double-blind, placebo-controlled trial study, 68 patients with acute ischemic stroke with the onset of symptoms less than 24 hours were randomly assigned to either the NAC-treated group or placebo-treated group. NAC and matched placebo were administrated by a 72-hour oral protocol (initially 4 grams loading dose and after on, 4 g in 4 equal divided doses for more 2 days). The primary outcomes were quantification of any neurologic deficit by the use of the National Institute of Health Stroke Scale (NIHSS) score and functional disability by the use of the modified Rankin scale (mRS) at 90 days after stroke. Additionally, serum levels of markers of oxidative stress and inflammation as a main mechanism of its action were assessed at baseline and the end of 3-day treatment protocol. Results: NAC-treated patients in comparison with placebo-treated patients showed a significantly lowermeanNIHSS scores at day 90 after stroke.A favorable functional outcomewhichwas defined as an mRS score of 0 or 1, also in favor of NAC compared to placebo was noted on day 90 after stroke (57.6% in the NAC-treated group compared with 28.6% in the placebo-treated group). Further, compared to the placebo, NAC treatment significantly decreased serum levels of proinflammatory biomarkers such as interleukin 6 (IL-6), soluble intercellular cell adhesion molecule-1 (sICAM-1), nitric oxide (NO), malondialdehyde (MDA), and neuron-specific enolase (NSE) and significantly increased serum levels of anti-oxidant biomarkers such as superoxide dismutase (SOD), glutathione peroxidase (GPx), and total thiol groups (TTG). Conclusion: The pattern of results suggests that oral NAC administration early after an acute ischemic stroke is associatedwith a better outcome profile in terms of acute neurological deficit and disability grade compared to placebo. NAC may improve neurological outcomes of patients with stroke at least in part by its antioxidant and anti-inflammatory effects.
Liquefied Petroleum Gas Concentration Monitoring System with Alarm and Cloud-Based Logging

Leakage of liquefied petroleum gas (LPG) has hazardous impacts on human beings which, if not cautiously attended to, can cause fire outbreak and asphyxia when inhaled in high concentration. LPG concentration measurement, monitoring, and control have been vastly researched; however, the aspects of sensor characterization and system performance assessment, using simulation and emulation responses considered in this study have not received adequate attention. The sensor dynamics model equations were used to graphically characterize the MQ-6 gas sensor. The ATMEGA328 microcontroller was used for signal conditioning and data processing due to its low power consumption and high processing speed. An assessment method was employed for the developed system, in which the degree of agreement between the system simulation and emulation responses were used as the metric for the system performance evaluation. The percentage absolute errors between the simulated and emulated responses were 0.02% (minimum) and 2.67% (maximum). The alarm activation occurred at the set value of 1000 ppm of LPG.
Metabolomic Pro ling of Brain Protective Effect of Edaravine on Cerebral Ischemia-reperfusion Injury in Mice

Hui-fen Ma China Pharmaceutical University Lin-jie Su China Pharmaceutical University Da-wei Zhang China Pharmaceutical University Shuai-shuai Gong China Pharmaceutical University Yi-ning Liu China Pharmaceutical University Yuan-yuan Zhang China Pharmaceutical University Fang Li China Pharmaceutical University Junping Kou (  junpingkou@cpu.edu.cn ) China Pharmaceutical University https://orcid.org/0000-0001-8377-915X
Trends of Diagnosis-Speci ﬁ c Work Disability After Newly Diagnosed Diabetes: A Four-Year Nationwide Prospective Cohort Study

OBJECTIVE We examined trends of diagnosis-speci ﬁ c work disability after newly diagnosed diabetes, comparing individuals with diabetes with those without diabetes, and identi ﬁ ed the subgroups with the highest levels of work disability. visits were used to identify new among ( n Data for a 4-year follow-up of ICD-10 physician-certi ed sickness absence and disability pension days (2007 2010) were obtained from the National Social Insurance Comparisons were made using a random sample of the population without recorded diabetes ( n = 39,056).
A Comparative Study of Computer-mediated and Spoken Conversations from Pakistani and U.S. English using Multidimensional Analysis

The present study compares four computer-mediated conversational registers (comments, Facebook (FB) groups, FB status updates and tweets), and spoken conversations from Pakistani and U.S. English using Biber's Multidimensional Analysis framework on three dimensions of variation, i.e. (i) Interactive versus Descriptive Explanatory Discourse, (ii) Expression of Stance, and (iii) Informational Focus versus 1 st Person Narrative. Spoken conversations have a high score on dimension 2, while CM conversations show register and regional variation on dimension 1 and 3. FB groups are significantly different between both regional varieties, followed by FB status updates, comments and tweets. Pakistani FB groups discuss self-help related topics, and appear to be slightly interactive and highly informational, while the U.S. ones are interactive and narrative discussing community and political issues. Pakistani FB status updates and tweets use English mainly for informational purposes, while the U.S. counterparts have an interactive and personal orientation indicating a wider functional role of English.
Life orientation and chosen sociomedical indicators of women suffering from type 2 diabetes

The aim of the study : In the process of dealing with diabetes every day the sense of coherence plays an important role. This construct in the salutogenesis theory determines the ability ofan individual to skilfully utilize the available resources for their own wellbeing. In many works the influence of demographic, social and clinical factors on the sense of coherence of people suffering from diabetes was analysed. However, little attention was paid to the detailed description of this issue among women suffering from diabetes. The aim of the study was to determine the relationship between the sense of coherence and the chosen sociomedical variables among women suffering from type 2 diabetes. Material and methods : In total 131 women suffering from type 2 diabetes treated at the Endocrinology Hospital and the Diabetes Outpatient Clinic were the subject of this research. The women who were selected for this research were 40 years old, had suffered from diabetes for over one year and gave permission to take part in the study.The study was conducted based on the original questionnaire comprising the data concerning: age, educational background, place of residence, marital status and professional activity. The questionnaire allowed gathering medical data like: duration of the disease, BMI index, HbA 1c value or the method of diabetes treatment.Life Orientation Questionnaire (SOC-29) by A. Antonovski [4] in a Polish language version was used to determine the rating of the sense of coherence. Results. The level of the sense of coherence of the surveyed women suffering from diabetes was between 47 and 197 points. Statistically significant differences were not observed ( p > 0.05) in the ratings of the sense of coherence versus the place of residence, education or marital status. There were no significant relationships ( p > 0.05) between the sense of coherence, its components and the method of treatment, HbA 1c value and the disease duration time. A statistically relevant difference ( p < 0.05) between the sense of coherence, its components and the age of respondents was demonstrated. Moreover, a statistically relevant difference was proven ( p < 0.05) between the sense of coherence and Body Mass Index. Furthermore, a statistically significant difference (p < 0.05) between the sense of coherence, its components and the professional of coherence and its components. 3. Women suffering from type 2 diabetes with normal body weight had high a level of the sense of coherence.