Miracle-dz/UniFAR-FTUs huggingface dataset:
Formulation of Herbal Tea and in Vitro Evaluation of Antibacterial Activity Against Drug-Resistant Uropathogens

The present study aims to formulate herbal tea and examine antioxidant and antimicrobial activity against uropathogens. Total phenolics content and radical scavenging activity of herbs (Hibiscus, Lemongrass, and Tinospora) and optimized tea were determined by the Folin–Ciocalteu method and percent of DPPH inhibition, respectively.The antibacterial activity of selected herbs and optimized tea were tested against three clinical isolates, Klebsiella pneumoniae, Escherichia coli, and Pseudomonas aeruginosa using the modified agar disc diffusion method. The highest phenolic content and radical scavenging activity were observed in lemongrass, followed by hibiscus flower and tinospora stem. Although, the highest antibacterial activity was recorded by hibiscus flower against all tested pathogens, followed by lemongrass and tinospora. The sensory score of different treatments of herbal tea was analyzed by the Hedonic scale and treatment T2 (55:20:25) is found to be best followed by T1, T0, T3. The radical scavenging activity and antibacterial activity of herbal tea were found to be higher than in green tea. The herbal tea also exhibit significant antibacterial activity against common uropathogens E.coli (0.73mm),K.pneumoniae(0.5 mm) and P.aeruginosa (0.4 cm). Therefore, the prepared herbal tea could be recommended for the prevention and treatment of urinary tract infection.
Pharmacokinetics and tissue distribution of bleomycin-induced idiopathic pulmonary fibrosis rats treated with cryptotanshinone

Introduction: Cryptotanshinone(CTS), a compound derived from the root of Salvia miltiorrhiza, has been linked to various of diseases, particularly pulmonary fibrosis. In the current study, we investigated the benefit of CTS on Sprague-Dawley (SD) rats induced by bleomycin (BLM) and established high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) methods to compare pharmacokinetics and tissue distribution in subsequent normal and modulated SD rats. Methods: The therapeutic effect of CTS on BLM-induced SD rats was evaluated using histopathology, lung function and hydroxyproline content measurement, revealing that CTS significantly improved SD rats induced by BLM. Additionally, a simple, rapid, sensitive and specific HPLC-MS/MS method was developed to determine the pharmacokinetics of various components in rat plasma. Results: Pharmacokinetic studies indicated that CTS was slowly absorbed by oral administration and had low bioavailability and a slow clearance rate. The elimination of pulmonary fibrosis in 28-day rats was slowed down, and the area under the curve was increased compared to the control group. Long-term oral administration of CTS did not accumulate in vivo, but the clearance was slowed down, and the steady-state blood concentration was increased. The tissue distribution study revealed that CTS exposure in the lungs and liver. Discussion: The lung CTS exposure was significantly higher in the model group than in the control group, suggesting that the pathological changes of pulmonary fibrosis were conducive to the lung exposure of CTS and served as the target organ of CTS.
Non-Minimal Approximation for the Type-I Seesaw Mechanism

A non-minimal approximation for effective masses of light and heavy neutrinos in the framework of a type-I seesaw mechanism with three generations of sterile Majorana neutrinos which recover the symmetry between quarks and leptons is considered. The main results are: (a) the next-order corrections to the effective mass matrix of heavy neutrinos due to terms O(θMD) are obtained, which modify the commonly used representation for the effective mass (MD is a Dirac neutrino mass when the electroweak symmetry is spontaneously broken); and (b) the general form of the mixing matrix is found in non-minimal approximation parametrized by a complex 3×3 matrix satisfying a nontrivial constraint. Numerical analysis within the νMSM framework demonstrates the very small effect of new contributions of direct collider observables as opposed to their possible significance for cosmological models.
Business Cycles, Regime Shifts, and Return Predictability

Abstract Consistent with the empirical properties of the consumption data, I develop a model in which consumption and dividend growth follow regime-switching dynamics. I show that regime-shift risk is priced in the model. Regime-shift risk exhibits dominant influence on asset prices: It generates a high equity premium and also induces time-varying risk premiums. The model explains major business cycle-dependent asset market phenomena and, in particular, the stronger predictability of stock returns during recessions.
Endophytic Fungi Regulate HbNHX1 Expression and Ion Balance in Hordeum bogdanii under Alkaline Stress

Plants cope with abiotic stress in several ways, including by collaborating with microorganisms. Epichloë, an endophytic fungus, has been shown to improve plant tolerance to extreme external environments. Hordeum bogdanii is a known salt-tolerant plant with the potential to improve alkaline lands. NHX1 plays a key role in the transport of ions in the cell and is overexpressed in plants with increased salt tolerance. However, the expression levels of HbNHX1 in Epichloë endophytic fungal symbionts in H. bogdanii have not been elucidated. We used Hordeum bogdanii (E+) with the endophytic fungi Epichloë bromicola and H. bogdanii (E−) without the endophytic fungi and compared the differences in the ion content and HbNHX1 expression between the shoots and roots of E+ and E− plants under alkaline stress. The absorption capacity of both K+ and Na+ of H. bogdanii with endophytic fungi was higher than that without endophytic fungi. In the absence of alkaline stress, endophytic fungi significantly reduced the Cl− content in the host H. bogdanii. Alkaline stress reduced SO42− content in H. bogdanii; however, compared with E−, endophytic fungi increased the content of SO42− in E+ plants. With an increase in the alkaline concentration, the expression of HbNHX1 in the roots of H. bogdanii with endophytic fungus exhibited an upward trend, whereas the expression in the shoots exhibited a downward trend first and then an upward trend. Under 100 mmol·L−1 mixed alkaline stress, the expression of HbNHX1 in E+ was significantly higher than that in E−, indicating that endophytic fungi could increase the Na+ region in vacuoles. The external environment affects the regulation of endophytic fungi in H. bogdanii and that endophytic fungi can play a key role in soil salinization. Therefore, the findings of this study will provide technical support and a theoretical basis for better utilization of endophytic fungi from H. bogdanii in saline land improvement.
Two-staged uplift of the southeast margin of the Tibetan plateau revealed by river longitudinal profiles

The Jinsha River, upstream of the Yangtze River, flows through the southeastern margin of the plateau, providing an opportunity to study the plateau uplift relative to the Sichuan basin through fluvial geomorphology. Eight tributaries of the Jinsha River located at the transition boundary from the plateau to the basin were analyzed for the feature of longitudinal profile and its evolution. The spatial distribution of slope-break knickpoints in the catchment was determined by slope-area analysis and integration analysis. Further, the magnitude and timing of the base level lowering (i.e., uplift of the Tibetan Plateau) were estimated by reconstructing the river longitudinal profile. The results show that there are two levels of slope-break knickpoints, with average elevations of 2865 m and 1523 m, corresponding to base levels relatively lowering of 1400 m and 1100 m, respectively. With reference to the long-term downcutting rate of the Jinsha River, the timings of these two phases base level lowering and uplifts are estimated to be ∼21–24 and ∼7–13 Ma, respectively. These are close to the timing of two uplifts revealed by inversion modeling of river longitudinal profiles. Therefore, the uplift of the studied region on the Tibetan Plateau can be divided into two stages, the early stage (∼20 Ma) uplift from 1500 to 2900 m and the late stage (∼10 Ma) uplift from 2900 to 4000 m, which further supports the staged outside uplift of the Tibetan Plateau.
The Diversity, Resistance Profiles and Plasmid Content of Klebsiella spp. Recovered from Dairy Farms Located around Three Cities in Pakistan

The rise of antimicrobial resistance (AMR) in bacterial pathogens such as Klebsiella pneumoniae (Kp) is a pressing public health and economic concern. The ‘One-Health’ framework recognizes that effective management of AMR requires surveillance in agricultural as well as clinical settings, particularly in low-resource regions such as Pakistan. Here, we use whole-genome sequencing to characterise 49 isolates of Klebisella spp. (including 43 Kp) and 2 presumptive Providencia rettgeri isolates recovered from dairy farms located near 3 cities in Pakistan—Quetta (n = 29), Faisalabad (n = 19), and Sargodha (n = 3). The 43 Kp isolates corresponded to 38 sequence types (STs), and 35 of these STs were only observed once. This high diversity indicates frequent admixture and limited clonal spread on local scales. Of the 49 Klebsiella spp. isolates, 41 (84%) did not contain any clinically relevant antimicrobial resistance genes (ARGs), and we did not detect any ARGs predicted to encode resistance to carbapenems or colistin. However, four Kp lineages contained multiple ARGs: ST11 (n = 2), ST1391-1LV (n = 1), ST995 (n = 1) and ST985 (n = 1). STs 11, 1391-1LV and 995 shared a core set of five ARGs, including blaCTX-M-15, harboured on different AMR plasmids. ST985 carried a different set of 16 resistance genes, including blaCTX-M-55. The two presumptive P. rettgeri isolates also contained multiple ARGs. Finally, the four most common plasmids which did not harbour ARGs in our dataset were non-randomly distributed between regions, suggesting that local expansion of the plasmids occurs independently of the host bacterial lineage. Evidence regarding how dairy farms contribute to the emergence and spread of AMR in Pakistan is valuable for public authorities and organizations responsible for health, agriculture and the environment, as well as for industrial development.
Generation and propagation of African squall lines

A study of squall lines affecting Minna, Nigeria during 1974–1976 emphasizes two particular aspects of their dynamics: that a strong jet around 650 mb is essential for their development, and that the forward edge of the squall line moves slightly faster than the maximum jet speed. A linear model of the squall line as a superposition of normal modes of an unstably stratified sheared flow sheds light on these observations. If the flow profile has a mid-level maximum, constructive interference of normal modes gives rise to an expanding circle of convection with an arc front moving slightly faster than the maximum mean flow speed, followed by individual cells. If, however, shear is unidirectional, there is no arc front, and a line of cells is formed moving at the middle level mean flow speed. These two cases are suggested as models for tropical and mid-latitude squall lines respectively, while a further case provides a possible model for storm-splitting.
Restoration of Developmental Competence in Low-Quality Porcine Cumulus–Oocyte Complexes through the Supplementation of Sonic Hedgehog Protein during In Vitro Maturation

Simple Summary Oocyte quality is acquired during ovarian folliculogenesis including oocyte growth and maturation, and plays a key role in subsequent embryo development. However, oocytes matured in vitro do not fully support the ability to develop into the blastocyst stage due to inadequate in vitro maturation (IVM) systems which do not sufficiently mimic the in vivo microenvironment. The sonic hedgehog (SHH) signaling pathway is important for ovarian folliculogenesis and oocyte maturation. Furthermore, our previous study demonstrated that low-quality porcine cumulus–oocyte complexes (COCs) exhibit low developmental competence with a weak SHH signaling pathway. Therefore, the aim of the present study was to clarify the restorative effects of SHH protein supplementation during IVM on the developmental competence of low-quality porcine COCs, as assessed by brilliant cresyl blue staining. The results showed that the low developmental competence of low-quality porcine COCs can be improved by supplementation with the SHH protein. This indicates that an active SHH signaling pathway is required for the acquisition of developmental competence in porcine COCs. Abstract The sonic hedgehog (SHH) pathway is an important signaling pathway for mammalian ovarian folliculogenesis and oocyte maturation. A previous study demonstrated that low-quality porcine cumulus–oocyte complexes (COCs) have low developmental competence, with lower SHH signaling protein expression before and after in vitro maturation (IVM) than high-quality COCs. However, there is no reported evidence on the restorative effects of SHH protein supplementation during the IVM of low-quality porcine COCs. Therefore, this study investigated the effects of SHH protein supplementation on the IVM of low-quality porcine COCs, as assessed by brilliant cresyl blue (BCB) staining. To examine this, we designed four groups: (i) BCB− (low-quality), (ii) BCB− + SHH, (iii) BCB+ (high-quality), and (iv) BCB+ + SHH. While the supplementation of SHH protein with high-quality COCs had no effect, supplementation with low-quality COCs significantly improved cumulus cell expansion, metaphase II rate, and subsequent embryo development following parthenogenetic activation. Our results provide the first evidence that the low developmental competence of low-quality porcine COCs can be improved by supplementation with the SHH protein. These results indicate that an active SHH signaling pathway is required for the acquisition of developmental competence in porcine COCs.
Passivated emitters in silicon solar cells

In high-efficiency silicon solar cells with low metal contact coverage fractions and high bulk lifetimes, cell performance is often dominated by recombination in the oxide-passivated diffusions on the cell surface. Measurements of the emitter saturation current density, J/sub o/, of oxide-passivated, boron and phosphorus diffusions are presented, and from these measurements, the dependence of surface recombination velocity on dopant concentration is extracted. The lowest observed values of J/sub o/ which are stable under UV light are given for both boron- and phosphorus-doped, oxide-passivated diffusions, for both textured and untextured surfaces. Contour plots which incorporate the above data were applied to two types of backside-contact solar cells with large area (37.5 cm/sup 2/) and one-sun efficiencies up to 22.7%. <<ETX>>
Experiments on the Transmission of Sound Through Jets

E on the superposition of a turbulent jet flow (0<A/<0.7) and pure tone sound coming from inside the nozzle are reported. A comparison between the transmitted sound power from the nozzle and the radiated sound power in the far field reveals a substantial attenuation at low frequencies. Therefore, a jet can be considered as a low-frequency muffler. It has been verified that this effect is independent of the broadband jet noise amplification previously reported by Bechert and Pfizenmaier.
Influence of Successive Wheelchair Tennis Matches on Handgrip Strength in High-Level Male Players

The purpose of this study was to examine the effects on upper strength in high-level male players playing four successive wheelchair tennis (WT) matches. Eight international WT players took part in a competition, playing one match per day over four consecutive tournament days. Before and after the match, the maximal isometric handgrip strength was measured on the dominant and non-dominant hand. Additionally, each player was equipped with one radiofrequency and IMU device on their wheelchair to control his activity profile (distance). The results showed significant differences between successive matches, with decreasing dominant handgrip strength (p = 0.02, η2 = 0.043), and there was a significant interaction between successive matches and the accumulated distance (p = 0.013, η2 = 0.049). The pre- and post-match strength values of the dominant hand decreased throughout the matches over a number of days, and post hoc analysis showed differences between the first and fourth matches only in pre-match strength (49.06 ± 6.96 vs. 45.94 ± 7.1; p = 0.045; ES: 1.04) but not in the non-dominant hand. Successive matches caused a decrease in the strength values of the WT players, mainly in the dominant hand. These results should be taken into account in the recovery and prevention of injuries in competitions with successive matches.
Truth-telling with a smartphone: The effect of communication media in strategic interactions

Introduction Technological advancements have transformed our business as well as social interactions. A recent trend is the increasing use of smartphones for work and customer engagement. Given that smartphones have been associated with a heightened sense of personal ownership and moral disengagement we argue that this may have negative implications for ethical behavior. Method To evaluate this conjecture we ran an experiment comparing dishonesty when using pen and paper, a desktop computer, or a smartphone. We make this comparison in both a setting where dishonesty benefits another (mutual-gain) and one where it harms another (constant-sum). Results We find higher levels of dishonesty when using a smartphone than pen and paper. We find relatively high levels of dishonesty when using a desktop computer in the mutual-gain setting but low levels in the constant-sum setting. Discussion Our results are consistent with the conjecture that smartphone use can lead to less ethical behavior. JEL codes C72, C91.
Stokes Profile Analysis and Vector Magnetic Fields. II. Formal Numerical Solutions of the Stokes Transfer Equations

Two numerical methods for formal integration of the Stokes transfer equations for line formation in a strong magnetic field were tested by computing Stokes profiles for a Zeeman triplet in a Milne-Eddington model atmosphere, and for the anomalously split Ca II K line in a realistic solar model. The first method is a Feautrier (1964) type method, in which the equations are written in second-order form and solved by finite-differences. The second method is a new solution called DELO, in which an integral equation for the Stokes vector is formulated in terms of the lambda operator (LO) associated with the diagonal elements (DE) of the absorption matrix. It is shown that the DELO method is faster and more accurate than the Feautrier method, and that both methods are more efficient than the Runge-Kutta integration method. 34 refs.
Combined effect of transcutaneous auricular vagus nerve stimulation and 0.1 Hz slow-paced breathing on working memory

Background Previous research has found that transcutaneous auricular vagus nerve stimulation (taVNS) can improve working memory (WM) performance. It has also been shown that 0.1 Hz slow-paced breathing (SPB, i.e., breathing at a rate of approximately 6 breaths/min) can significantly influence physical state and cognitive function via changes in autonomic afferent activity. In the present study, we investigated the synergistic effects of taVNS and SPB on WM performance. Methods A total of 96 healthy people participated in this within-subjects experiment involving four conditions, namely taVNS, SPB, combined taVNS with SPB (taVNS + SPB), and sham. Each participant underwent each intervention for 30 min and WM was compared pre- and post-intervention using the spatial and digit n-back tasks in a random order four times. Permutation-based analysis of variance was used to assess the interaction between time and intervention. Results For the spatial 3-back task, a significant interaction between time and intervention was found for the accuracy rate of matching trials (mACC, p = 0.03). Post hoc analysis suggested that both taVNS and taVNS + SPB improved WM performance, however, no significant difference was found in the SPB or sham groups. Conclusion This study has replicated the effects of taVNS on WM performance reported in previous studies. However, the synergistic effects of combined taVNS and SPB warrant further research.
Benzothiazole—An Antifungal Compound Derived from Medicinal Mushroom Ganoderma lucidum against Mango Anthracnose Pathogen Colletotrichum gloeosporioides (Penz and (Sacc.))

The present investigation is focused on exploring the possibilities of identifying biomolecules from the fruiting body of the medicinal mushroom Ganoderma lucidum against the mango anthracnose pathogen Colletotrichum gloeosporioides. The fruiting body (cap and stipe portion) of G. lucidum extracted with ethyl acetate solvent at a maximum inhibitory concentration of 1 percent exhibited the maximum mycelial growth inhibition of C. gloeosporioides with 70.10 percent and 40.77 percent, respectively. Furthermore, subjecting the ethyl acetate extracts from the cap portion of G. lucidum through thin layer chromatography (TLC) revealed the presence of two bands with Rf values of 0.38 and 0.35. The compounds eluted from band 1 recorded with the maximum mycelial growth inhibition of C. gloeosporioides by 53.77 percent followed by band 2 (46.33 percent) using an agar well diffusion test. Similarly, the analysis of ethyl acetate extracts from the cap portion of G. lucidum through Gas Chromatography-Mass spectroscopy (GC-MS) revealed the presence of the organoheterocyclic compound benzothiazole, as expressed in the highest peak area at 22.03 RT with the highest probability percentage (97%). Confirmation of the antifungal nature of benzothiazole was obtained by testing the standard sample of benzothiazole which showed a cent percent of inhibition on mycelial growth of C. gloeosporioides at 50 ppm minimum fungicidal concentration. Furthermore, benzothiazole caused abnormality in the mycelial structures, viz., distortion, shrinkage, clumping of mycelium, conidial malformation, and complete arrestment of conidial germination of C. gloeosporioides as observed through Scanning Electron Microscopy. The research on biomolecular extract of G. lucidum could be a novel and interesting concept for the possibility in suppression of plant pathogenic microbes in the natural field.
Theoretical Investigation of Spontaneous Polarization and Dielectric Constant of BaTiO3/SrTiO3 Superlattices

The spontaneous polarization and dielectric constant of BaTiO 3 (BT)/SrTiO 3 (ST) superlattices epitaxially grown on ST substrate are theoretically investigated using a microscopic quantum mechanical model based on the orbital approximation in correlation with the dipole-dipole interaction. Both the first-, second-, and third-order electronic polarizabilities were considered in this calculation in order to obtain accurate results for both the spontaneous polarization and relative dielectric constant of BT/ST superlattices. The calculations show that the spontaneous polarization of BT/ST superlattices increases with their richness in BT while the relative dielectric constant increases with their richness in ST.