Miracle-dz/UniFAR-FTUs huggingface dataset:
REFUTING IDEAS BASED ON SMALL BATCH OF DATA: MALACOTHERMOMETRY AID IN THE RECONSTRUCTION OF MEAN JULY PALEO-TEMPERATURES IN THE CARPATHIAN BASIN FOR THE LAST GLACIAL OF THE PLEISTOCENE

There are several ways in which terrestrial molluscs can be used to capture or model the former paleotemperatures. The most frequently used approaches are based on the utilization of the dominance values of the cold-loving and thermophilous species for the separation of relatively milder and colder periods. In other approaches, the abundance of the cold-loving forms is used to capture the short-term stadials. These previously mentioned approaches rely on the presumption that the fluctuations observable in the specimen number or percentages of cold-loving or thermophilous forms is related to the fluctuations of the paleo-temperature. On the other hand, the terrestrial mollusc faunas are also well-suited for capturing climate changes for the past 100 000 years utilizing their modern distribution patterns, similarly to insects, vertebrates and paleobotanical data. In this paper we present an updated version of the paleo-climatological, paleo-ecological model prepared by Sümegi (1989), and referred to as the malaco-thermometer method. The model uses the recent distribution, composition as well as dominance values of the individual species for the reconstruction of the paleotemperatures. The original method has been successfully applied to numerous radiocarbon-dated localities within the Carpathian Basin. In some works, hypothetical paleo-temperature curves based on the original model has been presented. However, there is one important deviation from the previously mentioned methods, namely that the activation temperatures for the terrestrial gastropods were captured not as the recorded mean July paleo-temperatures of the growth season in the center of distribution, but rather those recorded along the rims. Applications of the updated method and results gained via its utilization are presented.
The Climatic and Palaeoclimatic Significance of Rock Glaciers

Rock glaciers are characteristic and widespread large-scale flow features of frozen material in cold-climate high-relief regions. They are located at the foot of rock free-faces with a high supply of talus and, when active, typically take the form of 20-100 m thick tongueor lobeshaped bodies with cascading frontal slopes standing at the angle of repose. Their length may be as much as several kilometers, but the typical length is 200-800 m measured parallel to the flow direction. The longest rock glacier described from Earth is about 5.5 km in length (W Greenland). The surface of rock glaciers is typically covered by coarse (0.2-5 m) and angular rock fragments (talus), and displays a 1-5 m high curving transverse furrow-and-ridge topography. Active rock glaciers typically flow downslope 0.1-1 m per year, that is, they are more sluggish than normal glaciers, but are nevertheless presumably highly efficient as coarse debris transport agents due to their sheer size.
A Computational Model of Human Iron Metabolism

Iron is essential for virtually all organisms, yet it can be highly toxic if not properly regulated. Only the Lyme disease pathogen Borrelia burgdorferi has evolved to not require iron (Aguirre et al., 2013). Recent findings have characterised elements of the iron metabolism network, but understanding of systemic iron regulation remains poor. To improve understanding and provide a tool for in silico experimentation, a computational model of human iron metabolism has been constructed.COPASI was utilised to construct a model that included detailed modelling of iron metabolism in liver and intestinal cells. Inter-cellular interactions and dietary iron absorption were included to create a systemic computational model. Parameterisation was performed using a wide variety of literature data.Validation of the model was performed using published experimental and clinical findings, and the model was found to recreate quantitatively and accurately many results. Analysis of sensitivities in the model showed that, despite enterocytes being the only route of iron uptake, almost all control over the system is provided by reactions in the liver. Metabolic control analysis identified key regulatory factors and potential therapeutic targets.A virtual haemochromatosis patient was created and compared to a simulation of a healthy human. The redistribution of control in haemochromatosis was analysed in order to improve our understanding of the condition and identify promising therapeutic targets.Cellular prion protein (PrP) is an enigmatic protein, implicated in disease when misfolded, but its physiological role remains a mystery. PrP was recently found to have ferric-reductase capacity. Potential sites of ferric reduction were simulated and the findings compared to PrP knockout mice experiments. I propose that the physiological role of PrP is in the chemical reduction of endocytosed ferric iron to its ferrous form following transferrin receptor-mediated uptake.
Awareness Levels of Married Women Aged 20-60 Years about Gynaecological Cancer and the Affecting Factors

Background: Gynaecological cancers, defined as malign diseases of f male genital organ, are one of the biggest morbidity and mortality causes among women after br ast cancer. Objective: This descriptive and cross-sectional study was un dertaken in order to determine awareness levels of married women who utilized municipality women’s clu b about gynaecological cancer and the affecting fac tors. Methodology: The study was done at a municipality women’s club between the 15 th of April and the 15 of July, 2019. Therefore, 350 women who accepted to join the study were contacted to this end. The study data w ere collected using “Information Request Form” and “Gyn aecological Cancer Awareness Scale (GCAS). To analy ze the data, SPSS-22 statistical software was used. The da ta were assessed using Mann-Whitney U and Kruskal W al is tests. Results: Average age of the participant women was 36.87±9.7 9, 51.7% of them had primary school degrees, 66.9% of them lived in city centers and 83.7% of them did not work and 86.9% of them had a moderate income. In the study, Cronbach alpha coefficient was found to be 0 . 92 and women’s average GCAS score was satisfactory (157.54±17.41). Of some of the demographic characte istics; it was identified that educational level, the place where they lived the longest and income status affected G CAS-subdimensions and there was a statistically sig nificant difference (p<0.05). Besides, the status of being k owledgeable about gynaecological cancers and recei ving gynaecological cancer diagnosis affected GCAS-subdi mensions, too and a statistically significant diffe rence existed (p<0.05). Conclusion: Women’s some characteristics about their gynaecolo gical health and some demographic characteristics such as educational level, the place where they liv ed the longest and income status affected their awa reness of gynaecological cancers. In light of these results; it may be recommended that women who have low educa tional level, income level and live in rural areas should primarily be educated and trained in order to raise their awareness level of gynaecological cancers.
Culture of Pig Induced Pluripotent Stem Cells without Direct Feeder Contact in Serum Free Media

This article was originally published in a journal by OMICS Publishing Group, and the attached copy is provided by OMICS Publishing Group for the author’s benefit and for the benefit of the author’s institution, for commercial/research/educational use including without limitation use in instruction at your institution, sending it to specific colleagues that you know, and providing a copy to your institution’s administrator.
Elucidating the genetic basis for catheter blockage and encrustation in Proteus mirabilis

Indwelling urethral catheters are the most commonly used medical devices and catheter associated urinary tract infections (CAUTIs) are one of the most common hospital acquired infections. Over 40% of CAUTIs in long-term catheterised patients may be caused by the bacterium Proteus mirabilis. Urease produced by this bacterium generates alkaline conditions by breaking down urea, leading to the formation of dense crystalline biofilm structures on catheter surfaces. This crystalline biofilm makes infections hard to treat and causes the blockage of the catheter lumen, resulting in the retention of infected urine leading to episodes of ascending urinary tract infections.
Susceptibility to five antifungals of strains isolated from chronically colonised cystic fibrosis patients receiving azole therapy

HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignement et de recherche français ou étrangers, des laboratoires publics ou privés. Susceptibility to five antifungals of strains isolated from chronically colonised cystic fibrosis patients receiving azole therapy Adelina Amorim, Luísa Guedes-Vaz, Ricardo Araujo
An Investigation on the Knowledge, Attitudes and Be haviours to Complementary and Alternative Therapies among Physi c ans, Nurses, Patients and Patients’ Relatives

Background: Complementary and alternative treatment (CAM) meth ods have been practiced in every country since ancient times. Although it is used in differe nt types and shapes in each group, it is very popul ar in recent years. Aim: The study aimed to assess the knowledge, attitudes and behaviours to CAM among physicians, nurses, patients and patients’ relatives and to investigate this relationship according to positions. Method: The study designed in cross-sectional and descript ive type of study was performed in a private hospital. A personal information form was used to c ollect data for the study. The Pearson Chi-square t est was used to examine the relationship between two or mor e qualitative variables. Findings: The study was conducted used totally 350 participa nts, including 57 of who were physicians, 114 nurses, 23 patients and 156 patients’ relatives. Th e average age of study participants, 64.9% of whom were women and 61.4% single, was 30.34 ±9.01. Of the par ticipants, while 53.1% said that they believed in t he effectiveness of CAM methods, 61.1% said they thoug t complementary and alternative treatment techniqu es should be supported within the scope of the health insurance system. Besides, 33.7% of the participant s expressed using CAM methods, and 77.4% said they th ought that there was no difference between complementary and alternative medicine. Conclusions: The study found, by the position of participants, a significant difference between their usages of techniques other than medical treatment, their opin i ns on whether CAM poses health risks and their vi ews on whether there is any difference between complementa ry and alternative medicine and their cognisance of animal-assisted therapy (p ˂0.05). On the other hand, the study found no signif icant difference between participants’ usage of CAM and age, gender, civil s tatus, economic condition and whether the participa nt or a family member has a history of a chronic disease (p >0.05).
Rajakallio, Karoliina; Ristimäki, Miro; Andelin, Mia; Junnila, Seppo Business model renewal in context of integrated solutions delivery

Successful business model renewal requires the companies to understand the changes that the new business model causes with respect to their activities, value drivers and value appropriation logic. The study employs a comparative case study strategy. Conceptualizing business models as activities, the changes that adopting an integrated solution business model to implement a real estate development causes to the business models of companies in the project delivery network, compared to their business models applied in conventional project delivery networks following a disintegrated approach, is analyzed. The findings suggest that the shift towards more integrated project delivery models causes significant changes in the alignment of value drivers and value appropriation mechanisms across the network of firms. Simultaneously, companies adhere to their existing activity content and governance. The results contradict previous studies on the organizational impact of shift towards integrated solutions. Existing research on integrated solutions and alliances has primarily focused on developing practices from the perspective of a customer producer relationship. This study gives valuable insights related the importance of the internal logic of the service providers in achieving successful project coalition. keywords: Business model; Integrated solutions; Risk; Activities; Value supplementary material associated with this article can be found, in the online version, at doi:10.3846/1648715X.2016. 1249533
Giving Credence to the Experience of X-Linked Hypophosphatemia in Adulthood: An Interprofessional Mixed-Methods Study.

Purpose X-linked hypophosphatemia (XLH) is a rare X-linked dominant metabolic bone disease, often diagnosed in childhood but causing increasing physical debilitation and pain in adulthood. Physical comorbidities of XLH in adulthood include pervasive and early-onset degenerative arthritis, mineralizing enthesophytes and osteophytes, osteomalacia and pseudofracture, dental abscesses, and hearing loss. Methods This mixed-methods analysis included physical findings, diagnostic imaging, occupational and physical therapy assessments, and semi-structured interviews by social work to understand the functional outcomes and lived experience of XLH in adulthood, through connections between qualitative data obtained by social work and occupational therapy with the quantitative findings from other disciplines. Results Three primary themes of chronic pain, fear of falling, and lack of credence given by health care providers emerged from qualitative data and could be correlated with physical findings from functional outcome assessments These concerns contrasted with resilience, adaption, and compensation demonstrated by participants. Conclusions While new treatments may ease the burden of disease for adults with XLH, further research, increased provider awareness and education, and further development of standards of care are needed to promote accurate and adequate assessment and intervention for adults with XLH.
UNDERSTANDING STUDENTS’ PERCEPTION DIFFERENCES ON BLENDED LEARNING: AN EXPLORATIVE STUDY AMONG COLLEGE STUDENTS

Blended learning, which aims to combine the advantages of both the traditional, face-to-face instruction and e-learning, has recently become popular in higher education. Gaining a better understanding on students’ perceptions of blended learning could help ensure the success of student learning in this environment. Along this line, in this study, we adopted a wide range of assessment measures from multiple theoretical perspectives based on existing literature on blended learning as well as computing education in general, to measure students’ perceptions. Specifically, we examined and compared perception differences on blended learning across different groups of students based on their social and demographical traits, including gender, whether they are international students, and whether they are first generation college students. The results showed that, in most cases, female students, international students, or first generation college students tended to have more positive views on blended learning than male students, domestic students, or non-first generation college students, respectively.
Automating the Development of Chosen Ciphertext Attacks

In this work we investigate the problem of automating the development of adaptive chosen ciphertext attacks on systems that contain vulnerable format oracles . Unlike previous attempts, which simply automate the execution of known attacks, we consider a more challenging problem: to programmatically derive a novel attack strategy, given only a machine-readable description of the plaintext veriﬁcation function and the malleability characteristics of the encryption scheme. We present a new set of algorithms that use SAT and SMT solvers to reason deeply over the design of the system, producing an automated attack strategy that can entirely decrypt protected messages. Developing our algorithms required us to adapt techniques from a diverse range of research ﬁelds, as well as to explore and develop new ones. We implement our algorithms using existing theory solvers. The result is a practical tool called Delphinium that succeeds against real-world and contrived format oracles. To our knowledge, this is the ﬁrst work to automatically derive such complex chosen ciphertext attacks.
Shock within a shock: revisiting the radio flares of NS merger ejecta and gamma-ray burst-supernovae

Fast ejecta expelled in binary neutron star (NS) mergers or energetic supernovae (SNe) should produce late-time synchrotron radio emission as the ejecta shocks into the surrounding ambient medium. Models for such radio flares typically assume the ejecta expands into an unperturbed interstellar medium (ISM). However, it is also well-known that binary NS mergers and broad-lined Ic SNe can harbor relativistic jetted outflows. In this work, we show that such jets shock the ambient ISM ahead of the ejecta, thus evacuating the medium into which the ejecta subsequently collides. Using an idealized spherically-symmetric model, we illustrate that this inhibits the ejecta radio flare at early times $t < t_{\rm col} \approx 12 \, {\rm yr} \, (E_{\rm j}/10^{49} \, {\rm erg})^{1/3} (n/1 \, {\rm cm}^{-3})^{-1/3} (v_{\rm ej}/0.1c)^{-5/3}$ where $E_{\rm j}$ is the jet energy, $n$ the ISM density, and $v_{\rm ej}$ the ejecta velocity. We also show that this can produce a sharply peaked enhancement in the light-curve at $t = t_{\rm col}$. This has implications for radio observations of GW170817 and future binary NS mergers, gamma-ray burst (GRB) SNe, decade-long radio transients such as FIRST J1419, and possibly other events where a relativistic outflow precedes a slower-moving ejecta. Future numerical work will extend these analytic estimates and treat the multi-dimensional nature of the problem.
Revising the merger scenario of the galaxy cluster Abell 1644: a new gas poor structure discovered by weak gravitational lensing

The galaxy cluster Abell 1644 ($\bar{z}=0.047$) is known for its remarkable spiral-like X-ray emission. It was previously identified as a bimodal system, comprising the subclusters, A1644S and A1644N, each one centered on a giant elliptical galaxy. In this work, we present a comprehensive study of this system, including new weak-lensing and dynamical data and analysis plus a tailor-made hydrodynamical simulation. The lensing and galaxy density maps showed a structure in the North that could not be seen on the X-ray images. We, therefore, rename the previously known northern halo as A1644N1 and the new one as A1644N2. Our lensing data suggests that those have fairly similar masses: $M_{200}^{\rm N1}=0. 90_{-0.85}^{+0.45} \times10^{14}$ and $M_{200}^{\rm N2}=0. 76_{-0.75}^{+0.37} \times10^{14}$ M$_\odot$, whereas the southern structure is the main one: $M_{200}^{\rm S}=1. 90_{-1.28}^{+0.89}\times 10^{14}$ M$_\odot$. Based on the simulations, fed by the observational data, we propose a scenario where the remarkable X-ray characteristics in the system are the result of a collision between A1644S and A1644N2 that happened $\sim$1.6 Gyr ago. Currently, those systems should be heading to a new encounter, after reaching their maximum separation.
Combined analysis of Planck and SPTPol data favors the early dark energy models

We study the implications of the Planck temperature power spectrum at low multipoles, 0ℓ<100, and SPTPol data. We show that this combination predicts consistent lensing-induced smoothing of acoustic peaks within ΛCDM cosmology and yields the robust predictions of the cosmological parameters. Combining only the Planck large-scale temperature data and the SPTPol polarization and lensing measurements within ΛCDM model we found substantially lower values of linear matter density perturbation σ8 which bring the late-time parameter S8=σ8√Ωm/0.3=0.763±0.022 into accordance with galaxy clustering and weak lensing measurements. It also raises up the Hubble constant H0=69.68±1.00kms that reduces the Hubble tension to the 2. 5σ level. We examine the residual tension in the Early Dark Energy (EDE) model which produces the brief energy injection prior to recombination. We implement both the background and perturbation evolutions of the scalar field which potential scales as V(ϕ)∝ ϕ2n. Including cosmic shear measurements (KiDS, VIKING-450, DES) and local distance-ladder data (SH0ES) to the combined fit we found that EDE completely alleviates the Hubble tension while not degradating the fit to large-scale structure data. The EDE scenario significantly improves the goodness-of-fit by 2. 9σ in comparison with the concordance ΛCDM model. The account for the intermediate-redshift data (the supernova dataset and baryon acoustic oscillation data) fits perfectly to our parameter predictions and indicates the preference of EDE over ΛCDM at 3σ.
Connecting the metallicity dependence and redshift evolution of high-mass X-ray binaries

The integrated X-ray luminosity ($L_{\mathrm{X}}$) of high-mass X-ray binaries (HMXBs) in a galaxy is correlated with its star formation rate (SFR), and the normalization of this correlation increases with redshift. Population synthesis models suggest that the redshift evolution of $L_{\mathrm{X}}$/SFR is driven by the metallicity ($Z$) dependence of HMXBs, and the first direct evidence of this connection was recently presented using galaxies at $z\sim2$. To confirm this result with more robust measurements and better constrain the $L_{\mathrm{X}}$-SFR-$Z$ relation, we have studied the $Z$ dependence of $L_{\mathrm{X}}$/SFR at lower redshifts. Using samples of star-forming galaxies at $z=0.1-0.9$ with optical spectra from the hCOSMOS and zCOSMOS surveys, we stacked \textit{Chandra} data from the COSMOS Legacy survey to measure the average $L_{\mathrm{X}}$/SFR as a function of $Z$ in three redshift ranges: $z=0.1-0.25$, $0.25-0.4$, and $0.5-0.9$. We find no significant variation of the $L_{\mathrm{X}}$-SFR-$Z$ relation with redshift. Our results provide further evidence that the $Z$ dependence of HMXBs is responsible for the redshift evolution of $L_{\mathrm{X}}$/SFR. Combining all available $z>0$ measurements together, we derive a best-fitting $L_{\mathrm{X}}$-SFR-$Z$ relation and assess how different population synthesis models describe the data. These results provide the strongest constraints to date on the $L_{\mathrm{X}}$-SFR-$Z$ relation in the range of $8.0<$12+log(O/H)$<9.0$.
Let's be Humorous: Knowledge Enhanced Humor Generation

The generation of humor is an under-explored and challenging problem. Previous works mainly utilize templates or replace phrases to generate humor. However, few works focus on freer forms and the background knowledge of humor. The linguistic theory of humor defines the structure of a humor sentence as set-up and punchline. In this paper, we explore how to generate a punchline given the set-up with the relevant knowledge. We propose a framework that can fuse the knowledge to end-to-end models. To our knowledge, this is the first attempt to generate punchlines with knowledge enhanced model. Furthermore, we create the first humor-knowledge dataset. The experimental results demonstrate that our method can make use of knowledge to generate fluent, funny punchlines, which outperforms several baselines.