Miracle-dz/UniFAR-FTUs huggingface dataset:
A longitudinal study of Parent Reported Outcome Measures and a Parent Reported Experience Measure among British Child and Adolescent Mental Health Service attenders.

Structured Abstract: Purpose: Routine Outcome Monitoring (ROM) is currently seen as a key driver for service improvement at individual, team and service level. This paper explores the relationships between a Patient (parent) Reported Outcome Measure (PROM); a Practitioner reported outcome measure, and a Patient (parent) Reported Experience Measure (PREM). Design/methodology/approach: We recruited a cohort of 302 primary school-age children who were followed for one year from consecutively accepted referrals to three teams within two English Child and Adolescent Mental Health Services (CAMHS). Parents completed the Strengths and Difficulties Questionnaire (a PROM) and Practitioners completed the Clinician Global Assessment Scale at baseline, six and twelve months; parents completed the Experience of Services Questionnaire (a PREM) at 6 and 12 months. Findings: PROM and Practitioner reported outcome measure data suggested poor clinical outcome in terms of symptoms, impact and levels of functioning but were accompanied by PREM evidence of high levels of satisfaction. There was an unexpectedly low correlation (<0.2) between both measures of outcome and satisfaction Practical implications: A range of outcome measures are required to achieve a holistic view of service performance, and single measures may be extremely misleading. Originality/Value: This paper fulfils a need to explore the relationships between different outcome measures to contribute to the understanding of ROM its validity.
Role of self-help groups in women empowerment rural communities of Haryana

Women empowerment has long been viewed as the solution to many global problems especially in India when it comes to rural women. Self help groups can prove viable solution for raising the economic status of women as they are small voluntary association of people from the same socio-economic background with a purpose of solving their common problems through self help and mutual help. It can promote rural savings and provide gainful employment. Therefore a study was conducted to study the impact of SHG s on women empowerment. In Haryana, total rural population was 15868322; total no. of rural households 3159222 and a total no. of BPL household were 858389 in 2007. Sewa International in their report on women empowerment through SHGs mentioned that the most important change that the SHG culture has brought in the country is to change the gender dynamics of power within a family and ultimately the society at large and now they have greater say in the family matters and also are seen as stakeholders and partners in taking the community forward. The financial independence has eventually paved the way for soci et al. upliftment of women and their voices. The study was be conducted in Hisar and Karnal Districts of Haryana. A total of 120 respondents were surveyed with the help of well structured interview schedule The results revealed that 77.5 percent respondents had income upto 1,00,000 per annum and only 18.3 percent respondents below Rs. 1,00,000 to Rs. 2,00,000. It was also revealed that only 4.2 percent respondents had above Rs. 2,00,000 annual income. Regarding mass media exposure 49.2 percent respondents had medium level of media exposure. Regarding personal constraints 73.33 percent respondents reported increased work burden followed by 47.50 percent respondents who revealed non co-operative attitude of husband/in laws. Lack of family support was reported by 41.66 percent respondents and 16.66 percent respondents claimed that there was control of the husband over income. Regarding educational constraints 43.33 percent respondents reported of lack of timely information about govt subsidy (for purchase of animals/animal food). Regarding social and cultural empowerment attribute organizational skills have been given I st rank as perceived by the respondents followed by awareness of rights which is given II nd rank.
Direct and indirect effects of internal control weakness and external audit effort on accruals quality: Evidence from a unique Canadian regulatory setting

Public disclosure about effectiveness of internal control systems is subject to much controversy in Canada, resulting in Canadian disclosures being made in Management Discussion and Analysis (MD&A). These disclosures are provided to investors without a definition of the weaknesses to be reported, without implementation effectiveness testing, no direct management certification and no external audit of such disclosures. Though the cost of such SOX North disclosures are lower than in the U.S. setting, the credibility of these disclosures is far from assured, posing an important empirical issue for regulators interested in the cost versus benefit trade-off of various disclosure regimes. We use OLS regression and path analysis embedded in a structural model to examine the association between the strength of internal control and accrual quality in order to infer whether these disclosures are credible. The OLS regression finding of an overall negative net effect of internal control weaknesses on accrual quality is refined by recursive path analysis which shows that this overall negative effect is composed of a large negative direct effect of weaknesses on accrual quality and a smaller offsetting positive indirect effect of weaknesses on accrual quality via increased audit effort. The modest substitution effect implies that auditors cannot fully compensate for poor internal control by increased substantive work, which is per se evidence justifying some form of internal control disclosures for investors. Overall, our results suggest that lower cost SOX North disclosures are credible. This informs the cost-benefit debate facing regulators around the globe seeking alternatives to the costly U.S. model of internal control reporting. JEL Classifications: G38, M41, M42
Negative E ﬀ ect of Reduced NME1 Expression on Recurrence-Free Survival in Early Stage Non-Small Cell Lung Cancer

: This study aimed to understand whether the e ﬀ ect of non-metastatic cells 1 (NME1) on recurrence-free survival (RFS) in early stage non-small cell lung cancer (NSCLC) can be modiﬁed by β -catenin overexpression and cisplatin-based adjuvant chemotherapy. Expression levels of NME1 and β -catenin were analyzed using immunohistochemistry in formalin-ﬁxed para ﬃ n-embedded tissues from 425 early stage NSCLC patients. Reduced NME1 expression was found in 39% of samples. The median duration of follow-up was 56 months, and recurrence was found in 186 (44%) of 425 patients. The negative e ﬀ ect of reduced NME1 expression on RFS was worsened by cisplatin-based adjuvant chemotherapy (adjusted hazard ratio = 3.26, 95% CI = 1.16–9.17, p = 0.03). β -catenin overexpression exacerbated the e ﬀ ect of reduced NME1 expression on RFS and the negative e ﬀ ect was greater when receiving cisplatin-based adjuvant chemotherapy: among patients treated with cisplatin-based adjuvant chemotherapy, hazard ratios of patients with reduced NME1 expression increased from 5.59 (95% conﬁdence interval (CI) = 0.62–50.91, p = 0.13) to 15.52 (95% CI = 2.94–82.38, p = 0.001) by β -catenin overexpression, after adjusting for confounding factors. In conclusion, the present study suggests that cisplatin-based adjuvant chemotherapy needs to be carefully applied to early stage NSCLC patients with overexpressed β -catenin in combination with reduced NME1 expression.
Tumour necrosis factor a mediated apoptosis in murine macrophages by Salmonellaentericaserovar Typhi under oxidative stress

Invasive Salmonella has been reported to induce apoptosis of macrophages as part of its infection process, which may allow it to avoid detection by the innate immune system. However, the induction of apoptosis under the different host environments remains to be examined, including the oxidative stress experienced by pathogens in the macrophage milieu. To simulate in vivo oxidative conditions, Salmonella enterica serovar Typhi was grown in the presence of hydrogen peroxide and its ability to induce apoptosis of murine macrophages was assessed. Analysis of data revealed that oxidative stressed S . Typhi caused apoptotic cell death in 51% of macrophages, whereas S . Typhi grown under normal conditions accounted for apoptotic cell death in only 32% of macrophages. A signiﬁcant increase in the levels of oxidants and decrease in the antioxidant was also observed which correlated with the increased generation of tumour necrosis factor a , interleukin-1 a and interleukin-6. These results suggest that tumour necrosis factor a in conjunction with other cytokines may induce apoptotic cell death through the up-regulation of
GEOPOLYMER CONCRETE WITH LIME ADDITION AT NORMAL ROOM TEMPERATURE

: The development of infrastructure is increasing rapidly with an increase in the demand if concrete, where the primary binding material is cement. There are many adverse environmental issues caused by the production of cement. There is a need of finding alternatives for cement which also works like a binder. Geopolymer has been introduced in the research fields with an urge to overcome the demerits and adverse environmental issues caused by conventional concrete. This paper makes an effort to achieve the desired strength of Geopolymer concrete at normal room temperature by addition of Lime in the geopolymer concrete. In this experimental investigation Geopolymer concrete is produced for two different grades with fly ash as the binding material, Sodium Hydroxide and Sodium Silicate as the activators with 16Mole, aggregates and fine sand similar to that used for conventional concrete, adding Lime powder which when reacts with water produces an additional amount of heat (process being exothermic) which will help the polymerization process to develop at lower temperatures. Specimens casted with the mention specifications will be curing at normal room temperature.
Parental Concerns and Attitude Towards Children Diagnosed with Mental Retardation Attending Outpatient Unit of Yaba NeuroPsychiatric Hospital in Lagos, Nigeria Euro Global Contemporary Studies Journal (EGCSJ.COM)

Parents of children with mental retardation has economic, social and psychological, this concerns are real and may affect the level of care given and attitude by parent to their children. The study therefore investigated the concerns and attitude towards diagnosis of mental retardation among parents of children attending outpatient clinic of Yaba Neuro psychiatric Hospital, Lagos Nigeria. The research design was descriptive survey while the population for the study was 72 parents from outpatient department of Yaba Neuropsychiatric hospital, using total enumeration. A validated questionnaire was developed and used for gathering information on parental concerns and attitudes towards children diagnosed with mental retardation. The data from the survey was entered and analyzed descriptively and inferentially using Statistical Package for Social Scientists (SPSS) version 26. The findings showed that concerns among parents includes 51.4% social stigma, 83.3% cost of raising a mentally retarded children, 75% taking care of the mental retarded is exhausting, parental attitude toward mental retarded include 86.1% raising a mentally retarded children is a frustrating experience. The study also revealed that only psychological concerns influence attitude of parents towards their children. The researchers recommended among others that there should be preventative measures to reduce the factors that lead to mental retardation. It was also recommended the provision of rehabilitation services and training of children in schools and special institutes, besides supporting their families psychologically, socially and economically to reduce their concerns.
Interaction of (x-KG with basolateral organic anion transporter in isolated rabbit renal S3 proximal tubules in

Interaction of (x-KG with basolateral organic anion transporter isolated rabbit renal S3 proximal tubules Am. J. Physiol. 268 (Renal Fluid Electrolyte Physiol. 37): Fll09- Fl116, 1995. -To understand the basolateral p-aminohippu- rate (PAH) transporter in the S3 segment of rabbit proximal tubules and its relationship to the transporter in the S2 segment, we measured the 30-s uptake and efflux of PAH across the basolateral membrane of single isolated S3 segments at 37°C in bicarbonate-buffered media. Kinetic analysis of uptake data revealed a concentration of PAH at one-half Jmax of - 107 PM (same as in the S2 segment) but a J,, of 600 fmol*min-lnl-l (one-tenth that of S2 segment). The coefficient for efflux across the basolateral membrane was also only one-sixth to one-tenth of that in the S2 segment. These data suggest that the basolateral PAH transporter is the same in both segments but that there are fewer transporters in the S3 than in the S2 segment. However, the apparent inhibitor constant values for cis-inhibition by probenecid ( - 29 PM in S3, - 15 PM in S2) and by a-ketoglutarate ((x-KG) in the presence of LiCl ( - 40 FM in S3, - 160 PM in S2) suggest that the transporters may not be identical in the two segments. In bicarbonate-buffered medium, preloading the tubules with 100 FM CY-KG did not trans-stimulate PAH uptake across the basolateral membrane, whereas preloading with 1.0 ~J-M (x-KG caused a significant stimulation of 43%. However, in N-2-hydroxyethylpiperazine-N’-2-ethanesulfonic acid-buffered me- dium, preloading the tubules with 100 PM cc-KG caused a twofold increase in PAH uptake. These data suggest that the initial intracellular concentration of (x-KG (or metabolic state of the tubule) may influence PAH uptake and the trans-stimulatory effect of (x-KG.
Dalitz plot analysis of the decay B ± → K ± K ± K ∓

We analyze the three-body charmless decay B ± → K ± K ± K ∓ using a sample of 226 . 0 ± 2 . 5 million BB pairs collected by the B A B AR detector. We measure the total branching fraction and CP asymmetry to be B = (35 . 2 ± 0 . 9 ± 1 . 6) × 10 − 6 and A CP = ( − 1 . 7 ± 2 . 6 ± 1 . 5)%. We ﬁt the Dalitz plot distribution using an isobar model and measure the magnitudes and phases of the decay coeﬃcients. We ﬁnd no evidence of CP violation for the individual components of the isobar model. The decay dynamics is dominated by the K + K − S -wave, for which we perform a partial-wave analysis in the region m ( K + K − ) < 2 GeV /c 2 . Signiﬁcant production of the f 0 (980) resonance, and of a spin zero state near 1 . 55 GeV /c 2 are required in the isobar model description of the data. The partial-wave analysis supports this observation.
Corneal ulcer/keratitis derived Aspergillus ﬂavus & Aspergillus tamarii and their RAPD-PCR typing of King Saud University – Science

The aim of the study was investigate the DNA polymorphisms of Aspergillus ﬂavus and Aspergillus tamarii isolated from regional fungal keratitis cases based on random ampliﬁed polymorphic DNA (RAPD) analyses. Thirty-two A. ﬂavus and six A. tamarii isolates were identiﬁed using conventional macroscopic and microscopic features. Five decamer primers were used to amplify the genomic DNA sequences of the test isolates, and 140 total RAPD patterns were generated among them. From each of the 38 isolates, a range of 15–30 RAPD types were revealed. All of these were isolated from male farmers from Tamil Nadu. In the future, RAPD analyses could be employed as a reliable and rapid technique to differentiate among keratitis isolates of fungal pathogens.
NDT_A_233537 2063..2072

1Laboratory of Neuroscience (LIM27), Instituto de Psiquiatria do Hospital das Clinicas da Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil; 2Instituto Nacional de Psiquiatría Ramón de la Fuentel, México D.F. , México; 3Proesq Unifesp Schizophrenia Program Federal University of São Paulo, São Paulo, Brazil; 4Centro de Investigaciones del Sistema Nervioso, Grupo Cisne, Bogotá, Colombia; 5University of Guadalajara, Mexico, Hospital Civil de Guadalajara, “Fray Antonio Alcalde”, Guadalajara, Mexico; 6Instituto de Psiquiatria do HCFMUSP, São Paulo, Brazil; 7Medical Affairs, Janssen, Brazil; 8Medical Affairs, Janssen Canada, Toronto, ON, Canada Background: Paliperidone palmitate is a long-acting, second-generation antipsychotic (SGA) indicated for the treatment of acute exacerbations and maintenance treatment of adults with schizophrenia. This study addressed the response to paliperidone palmitate in Latin American patients with acute symptoms and recently diagnosed schizophrenia. Objective: Explore the efficacy and tolerability of paliperidone palmitate administered once a month for 4 months in patients with acute phase and recent diagnosis (within 1–6 years) of schizophrenia in 3 Latin American countries. Methods: This was a non-randomized, open-label, multicenter study with paliperidone palmitate injected intramuscularly in the deltoid muscle at an initial loading dose of 150 mg eq. (234 mg) on day 1 and 100 mg eq. (156 mg) on day 8 (± 4 days). The recommended maintenance dose was 75 mg eq. (117 mg) from day 36 to day 92. Efficacy was evaluated with PANSS and CGI-S. The last observation carried forward (LOCF) was used for efficacy analysis for imputation of missing data; no adjustments were made for multiplicity. Adverse events were evaluated during treatment. Results: The patient retention rate was 84.0% (144 patients received study drug; 121 finished the study). The percentage of patients with a reduction of at least 30% in PANSS total score compared to baseline gradually increased during the study, and at the end, 78.4% of patients showed response. The PANSS total score and CGI-S scores decreased significantly from baseline to LOCF endpoint (P <0.0001 for both); significant reduction in PANSS total score was observed at day 8 and persisted to the end of the study. Most common adverse events were muscle rigidity (11.8%), akathisia (11.1%), injection-site pain (7.6%), weight gain (7.6%), and insomnia (7.6%). Conclusion: Paliperidone palmitate was efficacious in Latin American patients studied with an acute exacerbation and recent diagnosis of schizophrenia, and no new safety signals were identified.
The Mediating Effect of Organizational Citizenship Behavior on the Relationship between Perceived Organizational Support and Turnover Intention: A Proposed Framework

Marketing ABSTRACT Employees’ turnover is an international phenomenon that is deliberated as tough challenge to the companies, as it is tiring and costly. Thus there is obligation for conducting more researches in order to support the academicians, practitioners, decision makers with better understanding of this dilemma and clarify more on the factors affecting these phenomena in deferent settings and contexts of research, particularly in the non-western perspectives such as Malaysia who is facing a big challenge toward the employees’ turnover in many sectors. Therefore, the purpose of this paper is determine the relationship between perceived organizational support, organizational citizenship behavior (benefiting the individual OCB-I, and benefiting the organization OCB-O) and turnover intention (TI). Due to that, this study proposed framework to study the effect of perceived organizational support on TI through the mediation role of OCB (OCB-I, OCB-O). In addition, the direct effect between the variables has been discussed. Hence this paper is expected to fill the research gap and contribute to the body of knowledge in this area of research.
E NDOGENEITY T EST : I NVESTMENT O PPORTUNITY S ET AND O WNERSHIP S TRUCTURE ON F UNDING P OLICIES

A company’s funding policy is an important part of determining a company’s capital structure. The policy must consider and analyze a combination of economical funding sources for the company’s routine financing and corporate investment. The aim of this research was to examine the relationship between investment opportunity set on funding policy and the ownership structure as a moderating variable (a variable that moderates the relationship between two other variables. With moderating variable, the relationship can be better or worse, depending on the effect). The population used in this research includes all companies that were publicly listed and traded on the Indonesia Stock Exchange between 2008 to 2018. The sampling technique used a purposive sampling method. There are several steps to answering the hypotheses in this research, which include (1) confirmatory factor analysis, (2) endogeneity tests, and (3) hypothesis testing through the use of multiple linear regression and moderation regression with panel data. The results indicated that investment opportunity set (TOBIN'Q) had a positive and significant effect on the company funding policy (Debt to Equity Ratio), while institutional and family ownership was found to weaken the influence of investment opportunity set (TOBIN'Q) on the company funding policies (Debt to Equity Ratio).
THROMBOSIS AND HEMOSTASIS Polyphosphate suppresses complement via the terminal pathway

released the circulation, it exerts prothrombotic and proinflammatory activities by modulating steps in the coagulation cascade. We examined the role of polyphosphate in regulatingtheevolutionarilyrelatedproteolyticcascadecomplement.Inerythrocytelysis assays, polyphosphate comprising more than 1000 phosphate units suppressed total hemolytic activity with a concentration to reduce maximal lysis to 50% that was 10-fold lower than with monophosphate. In the ion- and enzyme-independent terminal pathway complementassay,polyphosphatesuppressedcomplementinaconcentration-andsize-dependent manner. Phosphatase-treated polyphosphate lost its ability to suppress complement, confirming that polymer integrity is required. Sequential addition of polyphosphate to the terminal pathway assay showed that polyphosphate interferes with complement only when added before formation of the C5b-7 complex. Physicochemical analyses using native gels, gel filtration, and differential scanning fluorimetry revealed that polyphosphate binds to and destabilizes C5b,6, thereby reducing the capacity of the membrane attack complex to bind to and lyse the target cell. In summary, we have added another function to polyphosphate in blood, demonstrating that it dampens the innate immune response by suppressing complement. These findings further establish the complex relationship between coagulation and innate immunity. ( Blood . 2014;123(5):768-776)