Miracle-dz/UniFAR-FTUs huggingface dataset:
Fields of an electric line source parallel to an inhomogeneous dielectric layer with critical‐coupling regions

A characteristic surface impedance for an inhomogeneous dielectric slab that critically couples forward and backward travelling waves is computed using a generalized WKB method. The characteristic surface impedance, which is the tangential electric to magnetic field ratio at the surface of the slab, is a function of the transverse wave number. Using this expression for the characteristic surface impedance, the electric field excited by an electric line source parallel to the slab is derived. This solution is shown to be in good agreement with one derived from a rigorous analytical solution of the wave equation for the near, intermediate, and far-field regions.
The physical optics radar cross section of an elliptic cone

The physical optics approximation is used to evaluate the backseattering radar cross section of a semi-infinite metallic elliptic cone. The resulting formula can be directly interpreted as a generalization Of the well-known formula for the baekscattering cross section of a circular cone. In addition the bistatic radar cross section of the elliptic cone is calculated.
Evaluation of gallium-indium alloy as an acoustic couplant for high-impedance, high-frequency applications

Materials are investigated for coupling ultrasound between solid piezoelectric transducers and solid targets having acoustic impedances ranging between 10–20 MRayl. The majority of available acoustic couplants have impedances below 5 MRayl, leading to large surface reflections and acoustic losses. The desired couplant is preferably liquid or semiliquid with good conformability and low attenuation. This study examines the acoustic properties of various couplants, including gallium–indium alloys. Transmission tests were conducted at 19 MHz, concluding that these alloys are most appropriate for the stated application, with low attenuation, high acoustic impedance (17.4 MRayl), and a measured compressional velocity of 2740 m/s.
CD47-Dependent Regulation of Immune Checkpoint Gene Expression and MYCN mRNA Splicing in Murine CD8 and Jurkat T Cells

Elevated expression of CD47 in some cancers is associated with poor survival related to its function as an innate immune checkpoint when expressed on tumor cells. In contrast, elevated CD47 expression in cutaneous melanomas is associated with improved survival. Previous studies implicated protective functions of CD47 expressed by immune cells in the melanoma tumor microenvironment. RNA sequencing analysis of responses induced by CD3 and CD28 engagement on wild type and CD47-deficient Jurkat T lymphoblast cells identified additional regulators of T cell function that were also CD47-dependent in mouse CD8 T cells. MYCN mRNA expression was upregulated in CD47-deficient cells but downregulated in CD47-deficient cells following activation. CD47 also regulated alternative splicing that produces two N-MYC isoforms. The CD47 ligand thrombospondin-1 inhibited expression of these MYCN mRNA isoforms, as well as induction of the oncogenic decoy MYCN opposite strand (MYCNOS) RNA during T cell activation. Analysis of mRNA expression data for melanomas in The Cancer Genome Atlas identified a significant coexpression of MYCN with CD47 and known regulators of CD8 T cell function. Thrombospondin-1 inhibited the induction of TIGIT, CD40LG, and MCL1 mRNAs following T cell activation in vitro. Increased mRNA expression of these T cell transcripts and MYCN in melanomas was associated with improved overall survival.
Pathophysiology of Early Brain Injury and Its Association with Delayed Cerebral Ischemia in Aneurysmal Subarachnoid Hemorrhage: A Review of Current Literature

Background: Delayed cerebral ischemia (DCI) is a common and serious complication of aneurysmal subarachnoid hemorrhage (aSAH). Though many clinical trials have looked at therapies for DCI and vasospasm in aSAH, along with reducing rebleeding risks, none have led to improving outcomes in this patient population. We present an up-to-date review of the pathophysiology of DCI and its association with early brain injury (EBI). Recent Findings: Recent studies have demonstrated that EBI, as opposed to delayed brain injury, is the main contributor to downstream pathophysiological mechanisms that play a role in the development of DCI. New predictive models, including advanced monitoring and neuroimaging techniques, can help detect EBI and improve the clinical management of aSAH patients. Summary: EBI, the severity of subarachnoid hemorrhage, and physiological/imaging markers can serve as indicators for potential early therapeutics in aSAH. The microcellular milieu and hemodynamic pathomechanisms should remain a focus of researchers and clinicians. With the advancement in understanding the pathophysiology of DCI, we are hopeful that we will make strides toward better outcomes for this unique patient population.
Towards a Unified Asymptotic Theory for Autoregression

This paper develops an asymptotic theory for a first order autoregression with a root near unity. Deviations from the unit root theory are measured through a noncentrality parameter. When this parameter is negative we have a local alternative that is stationary; when it is positive, the local alternative is explosive; and when it is zero we have the standard unit root theory. Our asymptotic theory accommodates these alternatives and helps to unify earlier theory in which the unit root case appears as a singularity of the asymptotics. The general theory is expressed in terms of functionals of a simple diffusion process. The theory has applications to continuous time estimation and to the analysis of the asymptotic power of tests for a unit root under a sequence of local alternatives.
Green Tea in Reproductive Cancers: Could Treatment Be as Simple?

Simple Summary Green tea is a popular beverage worldwide and has shown to be beneficial in the treatment of different cancers. However, its role in the treatment of reproductive cancers remains controversial. This review aims to summarize the data available in the literature about the role of green tea in treating gynecological cancers. Examination of available evidence may provide a better understanding of the green tea benefits and focus future research related to this topic. Abstract Green tea originates from the tea plant Camellia sinensis and is one of the most widely consumed beverages worldwide. Green tea polyphenols, commonly known as catechins, are the major bioactive ingredients and account for green tea’s unique health benefits. Epigallocatechin-3-gallate (EGCG), is the most potent catechin derivative and has been widely studied for its pro- and anti-oxidative effects. This review summarizes the chemical and chemopreventive properties of green tea in the context of female reproductive cancers. A comprehensive search of PubMed and Google Scholar up to December 2022 was conducted. All original and review articles related to green tea or EGCG, and gynecological cancers published in English were included. The findings of several in vitro, in vivo, and epidemiological studies examining the effect of green tea on reproductive cancers, including ovarian, cervical, endometrial, and vulvar cancers, are presented. Studies have shown that this compound targets specific receptors and intracellular signaling pathways involved in cancer pathogenesis. The potential benefits of using green tea in the treatment of reproductive cancers, alone or in conjunction with chemotherapeutic agents, are examined, shedding light on new therapeutic strategies for the management of female reproductive cancers.
Spinocerebellar Ataxia in a Hungarian Female Patient with a Novel Variant of Unknown Significance in the CCDC88C Gene

Spinocerebellar ataxia (SCA) 40 is an extremely rare subtype of the phenotypically and genetically diverse autosomal dominant ataxias caused by mutations of the CCDC88C gene. Most reported cases of SCA40 are characterized by late-onset cerebellar ataxia and variable extrapyramidal features; however, there is a report of a patient with early-onset spastic paraparesis as well. Here, we describe a novel missense CCDC88C mutation (p.R203W) in the hook domain of the DAPLE protein encoded by the CCDC88C gene that was identified in a female patient who developed late-onset ataxia, dysmetria and intention tremor. To explore the molecular consequences of the newly identified and previously described CCDC88C mutations, we carried out in vitro functional tests. The CCDC88C alleles were expressed in HEK293 cells, and the impact of the mutant DAPLE protein variants on JNK pathway activation and apoptosis was assessed. Our results revealed only a small-scale activation of the JNK pathway by mutant DAPLE proteins; however, increased JNK1 phosphorylation could not be detected. Additionally, none of the examined mutations triggered proapoptotic effect. In conclusion, we identified a novel mutation of the CCDC88C gene from a patient with spinocerebellar ataxia. Our results are not in accord with previous observations and do not support the primary role of the CCDC88C mutations in induction of JNK pathway activation in ataxia. Therefore, we propose that CCDC88C mutations may exert their effects through different and possibly in much broader, yet unexplored, biological processes.
On the formation of metal cyanides and related compounds in the circumstellar envelope of IRC + 10216

Various pathways to the metal cyanides Na(CN), Mg(CN) and Al(CN) - some of which have been detected in the circumstellar envelope IRC + 10216 - are critically assessed. Calculations of rate coefficients for radiative association processes of the types M+ + HCN, M+ + HNC and M + CN, which are supported by ab initio calculations of the relevant bond strengths, molecular geometries and vibrational frequencies, allow us to conclude that none of these previously proposed pathways to M(CN) can account for the observed abundances of T-Na(CN), MgCN and MgNC within IRC + 10216. We propose that the observed sodium and magnesium cyanides are best accounted for by a mechanism involving radiative association of Na + and Mg+ with cyanopolyynes such as HCsN and HC7N, and discuss prospects for the formation of Al(CN) by an analogous mechanism. We also estimate the abundance ratiosn(NaCN) :n(T-Na(CN)) andn(AlCN) :n(AlNC), assuming an ion/ molecule source for these species and based on calculated thermochemical and spectroscopic properties for these isomers; the results suggest that virtually all Na(CN) and Al(CN) should be in the form of T-Na(CN) and linear AINC respectively, with poor prospects for the detection of the higher energy isomers NaCN and AlCN. Larger homologues of the metal cyanides, such as MNC2n + 1 (M = N a, Mg, Al; n = 1, 2, 3, 4 . ), may also arise in the dissociative recombination of MNC2n +1H+ ions. We assess the prospects for formation of the species MgC2 and MgCCH, and propose also that the metal amides MNH2 (M=Na, Mg, Al) constitute another class of compound whose formation in IRC + 10216 via an ion/ molecule mechanism, namely the reaction of M + with NH3 , appears highly likely.
Constitutive Androstane Receptor Agonist, TCPOBOP: Maternal Exposure Impairs the Growth and Development of Female Offspring in Mice

Environmental chemicals, which are known to impact offspring health, have become a public concern. Constitutive activated receptor (CAR) is activated by various environmental chemicals and participates in xenobiotic metabolism. Here, we described the effects of maternal exposure to the CAR-specific ligand 1,4-bis[2-(3,5-dichloropyridyloxy)] benzene (TCPOBOP, TC) on offspring health outcomes. Maternal TC exposure exhibited a stronger inhibition of body weight in 3-week-old and 8-week-old first-generation (F1) offspring female mice compared to controls. Further, maternal TC exposure obtained a strong increase in hepatic drug-metabolizing enzyme expression in 3-week-old female mice that persisted into 8-week-old adulthood. Interestingly, we observed distorted intestinal morphological features in 8-week-old F1 female mice in the TC-exposed group. Moreover, maternal TC exposure triggered a loss of intestinal barrier integrity by reducing the expression of intestinal tight junction proteins. Accordingly, maternal exposure to TC down-regulated serum triglyceride levels as well as decreased the expression of intestinal lipid uptake and transport marker genes. Mechanistically, maternal TC exposure activated the intestinal inflammatory response and disrupted the antioxidant system in the offspring female mice, thereby impeding the intestinal absorption of nutrients and seriously threatening offspring health. Altogether, these findings highlight that the effects of maternal TC exposure on offspring toxicity could not be ignored.
Epidemiology and Outcomes of Hypernatraemia in Patients with COVID-19—A Territory-Wide Study in Hong Kong

Background: Dysnatraemias are commonly reported in COVID-19. However, the clinical epidemiology of hypernatraemia and its impact on clinical outcomes in relation to different variants of SARS-CoV-2, especially the prevailing Omicron variant, remain unclear. Methods: This was a territory-wide retrospective study to investigate the clinical epidemiology and outcomes of COVID-19 patients with hypernatraemia at presentation during the period from 1 January 2020 to 31 March 2022. The primary outcome was 30-day mortality. Key secondary outcomes included rates of hospitalization and ICU admission, and costs of hospitalization. Results: In this study, 53,415 adult COVID-19 patients were included for analysis. Hypernatraemia was observed in 2688 (5.0%) patients at presentation, of which most cases (99.2%) occurred during the local “5th wave” dominated by the Omicron BA.2 variant. Risk factors for hypernatraemia at presentation included age, institutionalization, congestive heart failure, dementia, higher SARS-CoV-2 Ct value, white cell count, C-reactive protein and lower eGFR and albumin levels (p < 0.001 for all). Patients with hypernatraemia showed significantly higher 30-day mortality (32.0% vs. 5.7%, p < 0.001) and longer lengths of stay (12.9 ± 10.9 vs. 11.5 ± 12.1 days, p < 0.001) compared with those with normonatraemia. Multivariate analysis revealed hypernatraemia at presentation as an independent predictor for 30-day mortality (aHR 1.32, 95% CI 1.14–1.53, p < 0.001) and prolonged hospital stays (OR 1.55, 95% CI 1.17–2.05, p = 0.002). Conclusions: Hypernatraemia is common among COVID-19 patients, especially among institutionalized older adults with cognitive impairment and other comorbidities during large-scale outbreaks during the Omicron era. Hypernatraemia is associated with unfavourable outcomes and increased healthcare utilization.
Margin-Based Modal Adaptive Learning for Visible-Infrared Person Re-Identification

Visible-infrared person re-identification (VIPR) has great potential for intelligent transportation systems for constructing smart cities, but it is challenging to utilize due to the huge modal discrepancy between visible and infrared images. Although visible and infrared data can appear to be two domains, VIPR is not identical to domain adaptation as it can massively eliminate modal discrepancies. Because VIPR has complete identity information on both visible and infrared modalities, once the domain adaption is overemphasized, the discriminative appearance information on the visible and infrared domains would drain. For that, we propose a novel margin-based modal adaptive learning (MMAL) method for VIPR in this paper. On each domain, we apply triplet and label smoothing cross-entropy functions to learn appearance-discriminative features. Between the two domains, we design a simple yet effective marginal maximum mean discrepancy (M3D) loss function to avoid an excessive suppression of modal discrepancies to protect the features’ discriminative ability on each domain. As a result, our MMAL method could learn modal-invariant yet appearance-discriminative features for improving VIPR. The experimental results show that our MMAL method acquires state-of-the-art VIPR performance, e.g., on the RegDB dataset in the visible-to-infrared retrieval mode, the rank-1 accuracy is 93.24% and the mean average precision is 83.77%.
The Discount Rate in the Evaluation of Project Economic-Environmental Sustainability

The debate about project economic sustainability evaluation from a life cycle perspective focused on the conventional Life Cycle Costing (LCC). Despite the potentialities of the approach for evaluating design options at different scales (building/system/component/material), some limits emerge due to the neoclassical nature of the economic principles on which it is founded. The most important aspect of this debate is the necessity to clarify how to deal with environmental costs in the calculation, particularly in the case of public/PPP interventions. Two research topics emerge for strengthening the capability of LCC to deal with environmental components: (1) the LCC and environmental quantitative analysis (using Life Cycle Assessment) joint application; (2) the integration of the environmental dimension into the microeconomic approach, using appropriate discount rates. As known, these last are particularly relevant for public projects, in which the time value of money issue becomes crucial in presence of long lifespan analyses and economic objectives. Thus, the purpose of this paper is to explore alternative discounting modalities, for identifying the preferable one, towards an “environmental LCC model”. The research domain is therefore on the limits of LCC in dealing with environmental cost components, at the time being poorly studied by the scientific literature: this point represents the missing link which form the basis for the research problem to be addressed. The research design is focused on the investigation of environmental hurdle rate technique and the escalation rate approach, as alternatives to the standard “time preference” (financial) one. The LCC and the global cost are selected as the main tool for the analysis, which is founded on an empirical research methodology. The results, obtained by simulations on a case study (two alternative technological components), confirm the relevance of the discount rate effect on the Global Cost calculation by modelling some of the potential impacts of building components on the environment, e.g., the expectations of technological development over time. By the environmental hurdle rate, the results can even change the final preferability ranking obtained using financial rates. The value of the work consists of growing the debate on the topic and supporting environmentally responsible investment decisions in the building construction sector (new-build/retrofit of existing assets).
Can Respiration Complexity Help the Diagnosis of Disorders of Consciousness in Rehabilitation?

Background: Autonomic Nervous System (ANS) activity, as cardiac, respiratory and electrodermal activity, has been shown to provide specific information on different consciousness states. Respiration rates (RRs) are considered indicators of ANS activity and breathing patterns are currently already included in the evaluation of patients in critical care. Objective: The aim of this work was to derive a proxy of autonomic functions via the RR variability and compare its diagnostic capability with known neurophysiological biomarkers of consciousness. Methods: In a cohort of sub-acute patients with brain injury during post-acute rehabilitation, polygraphy (ECG, EEG) recordings were collected. The EEG was labeled via descriptors based on American Clinical Neurophysiology Society terminology and the respiration variability was extracted by computing the Approximate Entropy (ApEN) of the ECG-derived respiration signal. Competing logistic regressions were applied to evaluate the improvement in model performances introduced by the RR ApEN. Results: Higher RR complexity was significantly associated with higher consciousness levels and improved diagnostic models’ performances in contrast to the ones built with only electroencephalographic descriptors. Conclusions: Adding a quantitative, instrumentally based complexity measure of RR variability to multimodal consciousness assessment protocols may improve diagnostic accuracy based only on electroencephalographic descriptors. Overall, this study promotes the integration of biomarkers derived from the central and the autonomous nervous system for the most comprehensive diagnosis of consciousness in a rehabilitation setting.
Testing a covariance matrix: exact null distribution of its likelihood criterion

For X∼ N p (μ, Σ) testing H o:Σ = Σ 0, with Σ 0 known, relies at present on an approximation of the null-distribution of the likelihood ratio statistic. We present here the exact null distribution and also its computation, hence providing a precise tool that can be used in small sample cases.
Heart Failure Pharmacological Management: Gaps and Current Perspectives

Proper therapeutic management of patients with heart failure (HF) is a major challenge for cardiologists. Current guidelines indicate to start therapy with angiotensin converting enzyme inhibitors/angiotensin receptor neprilysin inhibitors (ACEi/ARNI), beta blockers (BB), mineralocorticoid receptor antagonists (MRAs) and sodium glucose cotransporter 2 inhibitors (SGLT2i) to reduce the risk of death and hospitalization due to HF. However, certain aspects still need to be defined. Current guidelines propose therapeutic algorithms based on left ventricular ejection fraction values and clinical presentations. However, these last do not always reflect the precise hemodynamic status of patients and pathophysiological mechanisms involved, particularly in the acute setting. Even in the field of chronic management there are still some critical points to discuss. The guidelines do not specify which of the four pillar drugs to start first, nor at what dosage. Some authors suggest starting with SGLT2i and BB, others with ACEi or ARNI, while one of the most recent approach proposes to start with all four drugs together at low doses. The aim of this review is to revise current gaps and perspectives regarding pharmacological therapy management in HF patients, in both the acute and chronic phase.