Miracle-dz/UniFAR-FTUs huggingface dataset:
Pancreatic damage control: the pancreas is simple don’t complicate it

Abstract Pancreatic trauma is a rare but potentially lethal injury because often it is associated with other abdominal organ or vascular injuries. Usually, it has a late clinical presentation which in turn complicates the management and overall prognosis. Due to the overall low prevalence of pancreatic injuries, there has been a significant lack of consensus among trauma surgeons worldwide on how to appropriately and efficiently diagnose and manage them. The accurate diagnosis of these injuries is difficult due to its anatomical location and the fact that signs of pancreatic damage are usually of delayed presentation. The current surgical trend has been moving towards organ preservation in order to avoid complications secondary to exocrine and endocrine function loss and/or potential implicit post-operative complications including leaks and fistulas. The aim of this paper is to propose a management algorithm of patients with pancreatic injuries via an expert consensus. Most pancreatic injuries can be managed with a combination of hemostatic maneuvers, pancreatic packing, parenchymal wound suturing and closed surgical drainage. Distal pancreatectomies with the inevitable loss of significant amounts of healthy pancreatic tissue must be avoided. General principles of damage control surgery must be applied when necessary followed by definitive surgical management when and only when appropriate physiological stabilization has been achieved. It is our experience that viable un-injured pancreatic tissue should be left alone when possible in all types of pancreatic injuries accompanied by adequate closed surgical drainage with the aim of preserving primary organ function and decreasing short and long term morbidity.
The impact of COVID‐19 confinement on the eating habits and lifestyle changes: A cross sectional study

Abstract Novel coronavirus (COVID‐19) emerged in December 2019 in the city of Wuhan, China causing severe respiratory infections and resulting in millions admissions to hospital and over a million deaths worldwide. Authorities imposed protective measures including confinement to flatten curves of casualties resulted in sudden lifestyle and eating habit changes. The objectives of this study were to observe the impact of the COVID‐19 lockdown on eating behavior and lifestyle of the Kurdish population in Iraqi Kurdistan. A structured cross‐sectional study was conducted from 1st to 14th of June when the lockdown finished with three different sections. Section one (6 questions) included socio‐demographic information section two (11 questions) composed of dietary behavior information including a) Mediterranean diet (MD) adherence using 14‐scaled items with a MD screener tool ranging from 0 to 14 b) and sections three (12 questions) composed of lifestyle habit changes such as physical activity, sleeping behavior, and smoking habit. The total number of included respondents was 2,137. The results showed that 12.0% (256) of participants stated that their lifestyle was improved, whereas 50.9% (1,087) declared their lifestyle deteriorated. In particular, the frequency of physical activity was decreased (McNemar value = 60.53, p <.001) and sleeping hours were significantly increased during lockdown (McNemar value = 447.93, p <.001). Regarding eating habits, it was noticed that 29.3% and 14.3% felt that appetite increased and decreased, respectively. The appetite change during lockdown was significantly associated with age (p =.0001), gender (p =.001), city (p =.007), and BMI (p =.001). Similarly, 32.4% reported weight gain. In conclusion, this study is among the earliest studies showing the effect of COVID‐19 on eating behavior and lifestyle changes. COVID‐19 confinement had a significant effect on lifestyle particularly reducing physical activity and changing eating habits.
Determination of iron chlorosis with extractable iron analysis in peach leaves

Abstract Iron (Fe) though indispensable for the biosynthesis of chlorophyll, but its total content in the plant was not associated with the occurrence of chlorosis. Iron, which is the ferrous‐iron (Fe2+) form—termed “active”; Fe— and extracted with weak acids and some chelating agents, has been closely related to Fe chlorosis. In this study, three different methods were tested in order to determine suitable methods for extractable‐Fe analysis in a Dixired peach cultivar. In the first two methods, o‐phenantroline (o‐Ph) and 1N hydrochloric acid (HCl) were used to extract Fe2+ from fresh leaves. In the third method, 1N HCl were used as an extractant on dried leaf samples. The relationship between chlorophyll content of the leaves and Fe extracted by the three methods, was statistically significant. Hydrochloric acid extraction with dried leaves which gave the highest significant correlation (r = 0.930) with chlorophyll content, can be used for the determination of Fe2+ ("active”; Fe) status in peach trees.
Combination of EP4 antagonist MF-766 and anti-PD-1 promotes anti-tumor efficacy by modulating both lymphocytes and myeloid cells

ABSTRACT Prostaglandin E2 (PGE2), an arachidonic acid pathway metabolite produced by cyclooxygenase (COX)-1/2, has been shown to impair anti-tumor immunity through engagement with one or more E-type prostanoid receptors (EP1-4). Specific targeting of EP receptors, as opposed to COX-1/2 inhibition, has been proposed to achieve preferential antagonism of PGE2–mediated immune suppression. Here we describe the anti-tumor activity of MF-766, a potent and highly selective small-molecule inhibitor of the EP4 receptor. EP4 inhibition by MF-766 synergistically improved the efficacy of anti-programmed cell death protein 1 (PD-1) therapy in CT26 and EMT6 syngeneic tumor mouse models. Multiparameter flow cytometry analysis revealed that treatment with MF-766 promoted the infiltration of CD8+ T cells, natural killer (NK) cells and conventional dendritic cells (cDCs), induced M1-like macrophage reprogramming, and reduced granulocytic myeloid-derived suppressor cells (MDSC) in the tumor microenvironment (TME). In vitro experiments demonstrated that MF-766 restored PGE2-mediated inhibition of lipopolysaccharide (LPS)-induced tumor necrosis factor (TNF)-α production in THP-1 cells and human blood, and PGE2-mediated inhibition of interleukin (IL)-2-induced interferon (IFN)-γ production in human NK cells. MF-766 reversed the inhibition of IFN-γ in CD8+ T-cells by PGE2 and impaired suppression of CD8+ T-cells induced by myeloid-derived suppressor cells (MDSC)/PGE2. In translational studies using primary human tumors, MF-766 enhanced anti-CD3-stimulated IFN-γ, IL-2, and TNF-α production in primary histoculture and synergized with pembrolizumab in a PGE2 high TME. Our studies demonstrate that the combination of EP4 blockade with anti-PD-1 therapy enhances antitumor activity by differentially modulating myeloid cell, NK cell, cDC and T-cell infiltration profiles.
Changes in diet and food shopping behaviors among Asian–American adults due to COVID‐19

COVID‐19 has changed diet and food shopping behaviors, but a lack of disaggregated data by racial and ethnic subgroup makes it challenging to identify whether specific populations are experiencing greater challenges in safely securing an adequate food supply and engaging in healthy eating behaviors during the pandemic. Thus, the objective of this study was to measure such changes among Asian–American (AA) adults, overall and by ethnic subgroup.
Analysis of the Clinicopathological Characteristics of Stage I–III Colorectal Cancer Patients Deficient in Mismatch Repair Proteins

Purpose To investigate the clinicopathological characteristics of stage I–III colorectal cancer (CRC) patients with deficient mismatch repair (dMMR) protein. Patients and Methods A retrospective analysis of 61 patients with stage I–III CRC confirmed by immunohistochemistry as dMMR after radical resection at Shenjing Hospital of China Medical University from May 2017 to June 2019 was performed. A total of 183 stage I–III CRC patients with proficient mismatch repair (pMMR) protein from the same period were randomly selected as a control group. The clinicopathological data of the two groups were investigated. Results There were significant differences between the two groups in age, sex, site of onset, maximum diameter of tumor, T stage, tumor differentiation, and histological type (P < 0.05). No significant difference was detected in nerve vessel invasion, cancer nodules, the N stage or the TNM stage. In the dMMR group, 41 patients (66.13%) showed PMS2/MLH1 deletion, and the number of MSH2/MSH6 deletion is 21 patients (33.87%). Among them, 34 patients (54.84%) had PMS2 and MLH1 deficiency. In total, 16 patients (25.81%) had MSH2 and MSH6 deficiency. A total of 5 patients (8.06%) showed simply PMS2 deletion and 5 patients (8.06%) showed simply MSH6 deletion. In total, 2 patients (3.23%) showed concurrent loss of PMS2, MLH1 and MSH2. No significant difference were found (P > 0.05) in the above factors among dMMR CRC patients with different MMR proteins deletions. Conclusion Our results show that dMMR status may be more likely exist in female and younger (≤55 years) patients with a greater tumor burden (>5cm), right colon, T4 stage disease, poor differentiation and mucinous adenocarcinoma. Loss of PMS2 and MLH1 is the most common pattern of MMR protein expression deficiency, followed by concurrent deletion of MSH2 and MSH6.
Antibody titers and rapid antigen testing in elderly patients with SARS-CoV-2 pneumonia vs. staff of ICU and “Covid-19” wards

Aim: The majority of patients hospitalized with COVID-19 are older individuals. Age and the comorbidities typically associated with it usually go hand in hand with a less favorable course of the disease. We were interested in the antibody response in this particular patient group as well as in the results of rapid antigen testing. Methods: In 30 elderly patients (>75 years), antibody titers (IgA and IgG) against COVID-19 were measured, and rapid antigen testing was determined about 3 weeks after the onset of symptoms of SARS-CoV-2 infection. The results were compared with those of a “high-risk” group consisting of “Covid-19” ward regular staff, as well as with “low-risk” staff consisting of members of the intensive care unit (ICU). The antibody titer against SARS-CoV-2 was determined by ELISA (EUROIMMUN™, PerkinElmer, Inc. Company); for rapid antigen testing, we used the SARS-CoV-2 Rapid Antigen test (Roche®). Results: Our investigations demonstrate a robust antibody response in the majority of elderly, comorbid patients about three weeks after the onset of infection. At this timepoint, most of the results of rapid antigen testing were negative. Furthermore, in the group of employees of our clinic (“Covid-19” ward vs. the ICU staff), the prevalence of antibodies was very low and antigen testing was negative in the whole ICU group. Conclusion: Although frequently comorbid, elderly patients are capable of significantly increasing antibodies against COVID-19 about 3 weeks after the onset of infection. Since the viral load can be assumed to have been low at that point, rapid antigen testing was negative in most cases. In the test group of employees of our clinic (“Covid-19” ward vs. the ICU staff), the data demonstrate that – given adequate protective measures – the risk of infection is not higher in a “Covid-19” ward compared to other wards.
Gas-phase basicity of several common MALDI matrices measured by a simple experimental approach

We present a combined experimental and theoretical study to determine the gas-phase basicity of several relatively small organic molecules that are used as matrices in MALDI: alpha-cyano-4-hydroxycynnamic acid (αCHCA), ferulic acid (FA), 3-hydroxypicolinic acid (HPA), sinapinic acid (SA), and 2,4,6-trihydroxyacetophenone (THAP). Our simple and fast experimental approach utilizes the ability of an electrosonic spray ionization (ESSI) source to produce high densities of gas-phase ions at ambient conditions, so that their gas-phase thermochemical properties can be probed in a bracketing-like experiment at atmospheric pressure, with no need for high vacuum. The reaction between the analyte and reference bases is monitored by a commercial mass spectrometer. We determined the following GB values of the MALDI matrices studied: 908.1 ± 0.8 (αCHCA), 863.8 ± 8.0 (FA), 876.3 ± 10.2 (HPA), 867.4 ± 1.4 (SA), and 864.2 ± 7.6 (THAP) kJ mol−1. A good agreement between the experimentally measured and computationally predicted (DFT-B3LYP, G4MP2) gas-phase basicities for the studied compounds is found, except for αCHCA for which the calculations resulted in approximately 80 kJ mol−1 lower GB. We attribute the observed discrepancy between the measured and calculated values to a gas-phase rearrangement of αCHCA into a heterocyclic aromatic isomer, 7-hydroxyquinoline-3-carboxylic acid (HQA). HQA is thermodynamically more stable and features higher GB than that of αCHCA (calculated at approximately 920 kJ mol−1). The gas-phase basicity values of THAP and HPA are reported for the first time.
The complete mitochondrial genome of Sardinella zunasi (Clupeiformes: Clupeidae)

Abstract The complete mitogenome of Sardinella zunasi was determined by next-generation sequencing. The S. zunasi mitogenome was a circular 16,307 bp molecule that contained 13 protein-coding genes, 22 tRNA genes, 2 rRNA genes, and one control region (D-loop). The gene arrangement was consistent with other Sardinella mitogenomes. The phylogenetic relationships of 29 Clupeoidei species based on 13 protein-coding genes from the available mitogenomes were analyzed. Sardinella zunasi clustered with Sardinella among Clupeidae, suggesting a closer relationship with this genus. These results will be useful for understanding the phylogenetic relationships, taxonomic classification, and phylogeography of the genus Sardinella relative to other genera of Clupeoidei.
Career Services in the Post‐COVID‐19 Era: A Paradigm for Career Counseling Unemployed Individuals

The 2019 novel coronavirus (COVID‐19) pandemic has caused unprecedented economic disruption and unemployment worldwide, threatening to become both a financial and a humanitarian crisis. Prolonged labor market recession and an acute rise of unemployment are expected. The main question for career counselors will be how to provide effective career counseling to unemployed people in the post‐COVID‐19 world, where they may face many other unemployment‐related problems. In this article, we suggest application of a holistic intervention model of career counseling for unemployed people that was designed to address the consequences of the acute financial recession in Greece.
Strategic Human Resource Management and COVID‐19: Emerging Challenges and Research Opportunities

At its core the COVID19 pandemic is a human crisis. Thus, human resource (HR) leaders have been central to the response in organisations globally. This contrasts with previous crises such as the global recession of 2008– 09 or the Y2K crisis at the turn of the millennium that accentuated the roles of finance and IT leaders, respectively. By amplifying the role of HR leaders, COVID19 has become an inflection point with substantive implications for HR globally. In this commentary, we reflect on the implications of COVID19 for HR research, including identifying some key research questions for strategic human resource management (HRM). Early in the evolution of the field, Wright and McMahan defined strategic HRM as ‘the pattern of planned human resource deployments and activities intended to enable the firm to achieve its goals’ (1992, p. 298). They argued that the domain of strategic HRM encompassed ‘the determinants of decisions about HR practices, the composition of human capital resource pools, the specification of the required human resource behaviours, and the effectiveness of these decisions given various business strategies and/or competitive situations’ (Wright and McMahon, 1992, p. 298). Since then, strategic HRM research has overwhelmingly focused on the relationship between HR practices and firm performance (Huselid, 1995) or the impact of those practices on mediators between Journal of Management Studies 58:5 July 2021 doi:10.1111/joms.12695
Accounting conservatism and firm performance during the COVID‐19 pandemic

Abstract We explore whether firms with more conditionally conservative accounting practices have higher stock returns than other firms during the Covid‐19 outbreak. We find evidence that Chinese firms listed on the Shanghai and Shenzhen Stock Exchanges applying more conditionally conservative reporting have lower declines in stock return performance during the Covid‐19 outbreak relative to other firms. We also find that the beneficial role of conditional conservatism is higher when firms have greater information asymmetry following the Covid‐19 pandemic. Our results are robust to various model specifications with four different measures of conservatism and an alternative return window.
Empathy Can Be Taught, and Patients Teach it Best

Empathy toward patients is an essential skill for a physician to deliver the best care for any patient. Empathy also protects the physician from moral injury and decreases the chances for malpractice litigations. The current graduate medical education curriculum allows trainees to graduate without getting focused training to develop empathy as a core competency domain. The tools to measure empathy inherently lack validity. The accurate measure of the provider’s empathy comes from the patient’s perspectives of their experience and their feedback, which is rarely reaching the trainee. The hidden curriculum in residency programs gives mixed messages to trainees due to inadequate role modeling by attending physicians. This narrative style manuscript portrays a teachable moment at the bedside vividly. The teaching team together reflected upon the lack of empathy, took steps to resolve the issue. The attending demonstrated role modeling as an authentic and impactful technique to teach empathy. The conclusion includes a proposal to include the patient’s real-time feedback to trainees as an essential domain under Graduate Medical Education core competencies of professionalism and patient care.
Complete mitochondrial genome and phylogenetic analysis of Schizothorax sinensis (Teleostei: Cypriniformes: Cyprinidae)

Abstract This study describes the first sequencing of the complete mitochondrial genome of Schizothorax sinensis, a species of cyprinid snowtrout from the Jialing River and Fujiang River basins in China’s Sichuan Province. The total length is 16,571 base pairs. Similar to most Schizothoracinae mitochondrial genomes, there are 37 genes including 13 protein coding genes, 22 transfer RNA genes and 2 ribosomal RNA genes. In addition, it contains a control region rich in A-T nucleotides. The overall nucleotide composition is 29.6% for A, 27.1% for C, 17.9% for G and 25.4% for T, and the percentage of GC content is 45.0%. Phylogenetic analysis suggested that Schizothorax sinensis and Schizothorax prenanti clustered together in a clade. This work provides additional molecular information for studying Schizothorax sinensis conservation genetics and evolutionary relationships.
110 A Single Centre Study on the Thirty-Day Hospital Reattendance and Readmission of Older Patients During the SARS-CoV-2 Pandemic

Abstract Introduction Hospital and social care suffered major alterations during the SARS-CoV-2 pandemic in the UK. Older adults were disproportionally affected by routine care disruption. To our knowledge, no data has been published so far on the impact of service disruption on 30-day readmission. Methods We performed a retrospective observational study of all patients admitted to a single east London hospital with laboratory-confirmed or clinical diagnosis of COVID-19 between 16th March and 6th April 2020. Older patients were defined as aged 80 years and over. Readmission was captured within 30 days of discharge. Comparator defined as the same period in 2019. Descriptive statistics were used. Results Three hundred and ninety-three patients were included. The majority survived to discharge (69.7%). Positive laboratory testing was similar between older and younger patients (85.7% vs 84.7%, p = NS). Mortality was significantly higher for older patients on index presentation (60.2% vs 20.3%, p < 0.001). Length of stay was also significantly longer for these patients (median 9 vs 7 days, p = 0.00694). The readmission rate for the 274 individuals discharged after index admission was 11.3% (n = 31). Amongst older patients, readmission rate during the study period was slightly higher than the same period in 2019 (17.9% vs 14.8%, p = 0.36). The median time interval between discharge and re-attendance was 8 [1–29]days. All re-attending older patients were re-admitted, whereas 54.2% of younger patients were sent home directly from the emergency department. Only 1 of the 31 patients re-attended because of insufficient social care. Conclusions Our data shows that readmission rates in the older population of East London during the SARS-CoV-2 pandemic were largely similar to non-pandemic periods. During this period, readmission rates appear to have been driven by clinical rather than social imperatives. This suggests that adapted social care services performed well and should be reinforced for future surges.
The Ethics of Deliberate Exposure to SARS‐CoV‐2 to Induce Immunity

Abstract We explore the ethics of deliberately exposing consenting adults to SARS‐CoV‐2 to induce immunity to the virus (‘DEI’ for short). We explain what a responsible DEI program might look like. We explore a consequentialist argument for DEI according to which DEI is a viable harm‐reduction strategy. Then we consider a nonconsequentialist argument for DEI that draws on the moral significance of consent. Additionally, we consider arguments for the view that DEI is unethical on the grounds that, given that large‐scale DEI would be highly likely to result in some severe illnesses and deaths, DEI amounts to a form of killing. Our thesis is that incorporating a DEI program alongside the status quo ‘calibrate the curve’ responses could have significant advantages at the early stages of pandemics. These potential advantages mean that, at a minimum, research into DEI would have been justified early in the COVID‐19 pandemic and that DEI programs should be explored as potential additions to our overall approach to emerging pandemics in the future.
Teaching an experiential field course via online participatory science projects: A COVID‐19 case study of a UC California Naturalist course

Abstract Experience and training in field work are critical components of undergraduate education in ecology, and many university courses incorporate field‐based or experiential components into the curriculum in order to provide students hands‐on experience. Due to the onset of the COVID‐19 pandemic and the sudden shift to remote instruction in the spring of 2020, many instructors of such courses found themselves struggling to identify strategies for developing rigorous field activities that could be completed online, solo, and from a student's backyard. This case study illustrates the process by which one field‐based course, a UC California Naturalist certification course offered at the University of California, Davis, transitioned to fully remote instruction. The transition relied on established, publicly available, online participatory science platforms (e.g., iNaturalist) to which the students contributed data and field observations remotely. Student feedback on the course and voluntary‐continued engagement with the participatory science platforms indicates that the student perspective of the experience was on par with previous traditional offerings of the course. This case study also includes topics and participatory science resources for consideration by faculty facing a similar transition from group field activities to remote, individual field‐based experiences.