Miracle-dz/UniFAR-FTUs huggingface dataset:
Explanatory models of mental illness among working professionals diagnosed with bipolar or depression in the United States

Background: People diagnosed with mental illness develop a variety of explanatory models of their conditions in the face of uncertainty. Explanatory models matter because they are associated with internalized stigma and illness behaviors such as treatment preferences. Aims: This paper explores how working professionals in the United States draw on biological and/or environmental factors to explain the cause(s) of their diagnoses of bipolar or depression. Method: Findings are derived from an analysis of transcripts of in-depth interviews with 52 individuals from across the United States who were invited to participate in a study of working professionals diagnosed with mental illness. About 25 self-identified as having bipolar disorder and 27 as having major depression. Transcript data were analyzed following the principles of flexible coding with the goal of establishing a typology of explanatory models of self-identified bipolar versus depression. Results: Six types of explanatory models emerged from the analysis. One was exclusively biological, a second was exclusively environmental, and the remaining four combined biological and environmental factors in different ways. Quotations from the interviews are provided to illustrate each type, and comparisons between types are made based on primary diagnosis (bipolar vs. depression), and self-reports of trauma and stressful experiences. Conclusion: Implications for the future research on explanatory models and how they may impact people who are diagnosed with a mental illness across multiple dimensions of their lives are presented.
Intensive care unit versus floor admission following lower extremity free flap surgery: Is there a difference in outcomes?

Free tissue transfer (FTT) lower limb salvage requires costly multidisciplinary care. Traditionally, patients who undergo FTT reconstruction for lower extremity (LE) wounds were admitted to the intensive care unit (ICU) in the immediate postoperative period for close monitoring. During the COVID‐19 pandemic, our practice shifted toward admitting FTT patients to the floor postoperatively instead of the ICU. The purpose of this study is to compare surgical outcomes in patients admitted to the floor versus ICU immediately following LE free flap reconstruction.
General principles in the interpretation of quantum mechanics

The three major theoretical principles of quantum mechanics relevant to its interpretation are: (T1), linearity; (T2), invariance under certain groups; and (T3) the orthogonality and isolation of the different branches of the state vector. These three imply the particle-like properties of mass, energy, momentum, spin, charge, and locality are actually properties of the state vector; and this in turn implies there is no evidence for the existence of particles. Experimentally there is no evidence for collapse (E1) and theoretically linearity prohibits collapse. One also has the experimentally verified probability law (E2), which is found to rule out the many-worlds interpretation. The failure of these three major interpretation, particles, collapse, and many-worlds, apparently implies an acceptable interpretation must be based on perception. Rather than being a separate principle, probability follows in this interpretation from a weak assumption on perception plus the combinatorics when an experiment is run many times. This suggests a relatively simple experimental test of the perception interpretation.
ACTIVE AND PASSIVE OSMOTIC ADJUSTMENT IN OLIVE TREE LEAVES DURING DROUGHT STRESS

We evaluated the osmotic adjustment capacity of two-year-old olive trees (Olea europaea L.) grown in pots in a greenhouse during a period of drought stress. Total osmotic adjustment increased with increasing severity of drought stress. Trees in the high stress treatment showed a total osmotic adjustment of 2.1 MPa and 2.8 MPa for the cultivars ‘Meski’ and ’Koroneiki’, respectively, 30 days after imposing drought stress. Osmotic adjustment allowed the leaves to reach total water potentials of -4.3 and -6.0 MPa for ‘Meski’ and ‘Koroneiki’, respectively. Osmotic adjustment (OA) in olive trees was associated with active (AOA) and passive (POA) osmotic regulation mechanisms. Using a regression analysis with some of the key osmoregulatory compounds (i.e. proline, soluble sugars and potassium), we found that ‘Koroneiki’ tends to adopt a passive strategy (POA) to tolerate progressive drought stress (confirmed by a reduction in leaf water content), while ‘Meski’ used an active strategy (AOA) and was able to maintain its leaf water content.
Plasma and Cerebrospinal Fluid Population Pharmacokinetics of Meropenem in Neurocritical Care Patients: a Prospective Two-Center Study

Morbidity and mortality related to ventriculitis in neurocritical care patients remain high. Antibiotic dose optimization may improve therapeutic outcomes. ABSTRACT Morbidity and mortality related to ventriculitis in neurocritical care patients remain high. Antibiotic dose optimization may improve therapeutic outcomes. In this study, a population pharmacokinetic model of meropenem in infected critically ill patients was developed. We applied the final model to determine optimal meropenem dosing regimens required to achieve targeted cerebrospinal fluid exposures. Neurocritical care patients receiving meropenem and with a diagnosis of ventriculitis or extracranial infection were recruited from two centers to this study. Serial plasma and cerebrospinal fluid samples were collected and assayed. Population pharmacokinetic modeling and Monte Carlo dosing simulations were performed using Pmetrics. We sought to determine optimized dosing regimens that achieved meropenem cerebrospinal fluid concentrations above pathogen MICs for 40% of the dosing interval, or a higher target ratio of meropenem cerebrospinal fluid trough concentrations to pathogen MIC of ≥1. In total, 53 plasma and 34 cerebrospinal fluid samples were obtained from eight patients. Meropenem pharmacokinetics were appropriately described using a three-compartment model with linear plasma clearance scaled for creatinine clearance and cerebrospinal fluid penetration scaled for patient age. Considerable interindividual pharmacokinetic variability was apparent, particularly in the cerebrospinal fluid. Percent coefficients of variation for meropenem clearance from plasma and cerebrospinal fluid were 41.7% and 89.6%, respectively; for meropenem, the volume of distribution in plasma and cerebrospinal fluid values were 63.4% and 58.3%, respectively. High doses (up to 8 to 10 g/day) improved attainment of meropenem cerebrospinal fluid target exposures, particularly for less susceptible organisms (MICs, ≥0.25 mg/L). Standard meropenem doses of 2 g every 8 h may not achieve effective concentrations in cerebrospinal fluid in all critically ill patients. Higher doses, or alternative dosing methods (e.g., loading dose followed by continuous infusion) may be required to optimize cerebrospinal fluid exposures. Doses of up to 8 to 10 g/day either as intermittent boluses or continuous infusion would be suitable for patients with augmented renal clearance; lower doses may be considered for patients with impaired renal function as empirical suggestions. Ongoing dosing should be tailored to the individual patient circumstances. Notably, the study population was small and dosing recommendations may not be generalizable to all critically ill patients.
Revisiting Clickers: In-Class Questions Followed by At-Home Reflections Are Associated with Higher Student Performance on Related Exam Questions

Clicker questions are a commonly used active learning technique that stimulates student interactions to help advance understanding of key concepts. Clicker questions are often administered with an initial vote, peer discussion, and a second vote, followed by broader classroom explanation. ABSTRACT Clicker questions are a commonly used active learning technique that stimulates student interactions to help advance understanding of key concepts. Clicker questions are often administered with an initial vote, peer discussion, and a second vote, followed by broader classroom explanation. While clickers can promote learning, some studies have questioned whether students maintain this performance on later exams, highlighting the need to further understand how student answer patterns relate to their understanding of the material and to identify ways for clickers to benefit a broader range of students. Systematic requizzing of concepts during at-home assignments represents a promising mechanism to improve student learning. Thus, we paired clicker questions with at-home follow-up reflections to help students articulate and synthesize their understandings. This pairing of clickers with homework allowed us to decipher how student answer patterns related to their underlying conceptions and to determine if revisiting concepts provided additional benefits. We found that students answering both clicker votes correctly performed better on isomorphic exam questions and that students who corrected their answers after the first vote did not show better homework or exam performance than students who maintained an incorrect answer across both votes. Furthermore, completing the follow-up homework assignment modestly boosted exam question performance. Our data suggest that longer-term benefits of clickers and associated homework may stem from students having repeated opportunities to retrieve, refine, and reinforce emerging conceptions.
High levels of surgical antibiotic prophylaxis: Implications for hospital-based antibiotic stewardship in Sierra Leone

Abstract Objective: Despite the impact of inappropriate prescribing on antibiotic resistance, data on surgical antibiotic prophylaxis in sub-Saharan Africa are limited. In this study, we evaluated antibiotic use and consumption in surgical prophylaxis in 4 hospitals located in 2 geographic regions of Sierra Leone. Methods: We used a prospective cohort design to collect data from surgical patients aged 18 years or older between February and October 2021. Data were analyzed using Stata version 16 software. Results: Of the 753 surgical patients, 439 (58.3%) were females, and 723 (96%) had received at least 1 dose of antibiotics. Only 410 (54.4%) patients had indications for surgical antibiotic prophylaxis consistent with local guidelines. Factors associated with preoperative antibiotic prophylaxis were the type of surgery, wound class, and consistency of surgical antibiotic prophylaxis with local guidelines. Postoperatively, type of surgery, wound class, and consistency of antibiotic use with local guidelines were important factors associated with antibiotic use. Of the 2,482 doses administered, 1,410 (56.8%) were given postoperatively. Preoperative and intraoperative antibiotic use was reported in 645 (26%) and 427 (17.2%) cases, respectively. The most commonly used antibiotic was ceftriaxone 949 (38.2%) with a consumption of 41.6 defined daily doses (DDD) per 100 bed days. Overall, antibiotic consumption was 117.9 DDD per 100 bed days. The Access antibiotics had 72.7 DDD per 100 bed days (61.7%). Conclusions: We report a high rate of antibiotic consumption for surgical prophylaxis, most of which was not based on local guidelines. To address this growing threat, urgent action is needed to reduce irrational antibiotic prescribing for surgical prophylaxis.
Functional and Metagenomic Evaluation of Ibezapolstat for Early Evaluation of Anti-Recurrence Effects in Clostridioides difficile Infection

Reduction of Clostridioides difficile infection (CDI) recurrence is an essential endpoint for CDI-directed antibiotic development that is often not evaluated until Phase III trials. The purpose of this project was to use a functional and metagenomic approach to predict the potential anti-CDI recurrence effect of ibezapolstat, a DNA polymerase IIIC inhibitor, in clinical development for CDI. ABSTRACT Reduction of Clostridioides difficile infection (CDI) recurrence is an essential endpoint for CDI-directed antibiotic development that is often not evaluated until Phase III trials. The purpose of this project was to use a functional and metagenomic approach to predict the potential anti-CDI recurrence effect of ibezapolstat, a DNA polymerase IIIC inhibitor, in clinical development for CDI. As part of the Phase I ibezapolstat clinical study, stool samples were collected from 22 healthy volunteers, who were given either ibezapolstat or vancomycin. Stool samples were evaluated for microbiome changes and bile acid concentrations. Ibezapolstat 450 mg and vancomycin, but not ibezapolstat 300 mg, showed statistically significant changes in alpha diversity over time compared to that of a placebo. Beta diversity changes confirmed that microbiota were significantly different between study groups. Vancomycin had a more wide-ranging effect on the microbiome, characterized by an increased proportion of Gammaproteobacteria. Ibezapolstat demonstrated an increased proportion of Actinobacteria, including the Bifidobacteriaceae family. Using a linear regression analysis, vancomycin was associated with significant increases in primary bile acids as well as primary:secondary bile acid ratios. An overabundance of Enterobacteriaceae was most highly correlated with primary bile acid concentrations (r = 0.63; P < 0.0001). Using Phase I healthy volunteer samples, beneficial changes suggestive of a lower risk of CDI recurrence were associated with ibezapolstat compared to vancomycin. This novel omics approach may allow for better and earlier prediction of anti-CDI recurrence effects for antibiotics in the clinical development pipeline.
Vortex ring connection to a free surface

Abstract We perform numerical simulations of the interaction between a vortex ring and a free surface, and provide a new interpretation of the mechanism by which the vortex ring connects to the free surface. Large vorticity gradients at the free surface result in the diffusion of surface-tangential vorticity out of the fluid. This is accompanied by the diffusion of opposite-signed surface-normal vorticity away from the connection line, along the free surface, which results in the attachment of the vortex ring to the free surface. Compared to existing descriptions, this interpretation explains better how the solenoidal property that vortex lines do not end in the fluid is maintained. By including an interface vortex sheet at the free surface, the important property of vorticity conservation is maintained throughout the interaction. The upper part of the vortex ring simply diffuses out of the fluid, and into the interface vortex sheet, with the total circulation remaining constant.
Characterizing Sea Turtle Bycatch in the Recreational Hook and Line Fishery in Southeastern Virginia, USA

Abstract. Although commercial hook and line fisheries pose a well-documented and significant threat to worldwide sea turtle populations, recreational hook and line fisheries remain understudied. This article describes information from sea turtle bycatch reported from interactions in the recreational hook and line fishery, as well as survey results from recreational anglers in Virginia from 2014 through 2018. Reports of interactions increased annually during the study with Kemp's ridley sea turtles (Lepidochelys kempii) reported most frequently (n = 162), followed by 45 loggerheads (Caretta caretta), 6 green turtles (Chelonia mydas), and 39 unidentified sea turtles. Commonly encountered bait types were similar between surveyed anglers and bait used during turtle interactions, with significantly more squid bait noted during turtle interactions (51%) than used by surveyed anglers (29%) (χ2 = 41.32, p < 0.0001). Additionally, bloodworms and artificial bait were encountered comparatively less frequently during turtle interactions. Overall, interactions with the hook and line recreational fishery in Virginia appear opportunistic and involve otherwise healthy animals, presenting limited means for mitigating sea turtle bycatch. In the absence of regulatory oversight of bycaught sea turtles in the recreational fishery, mitigating injury from these interactions through targeted outreach provides a short-term solution to reducing the severity of these inevitable interactions.
Experimental Biology in Conflict Resolutions: The Case of Pelicans and Cormorants in Israel

In Israel, which is a bottleneck for some six hundred million migrating birds, the drainage of the Hula Lake in the north resulted in serious conflicts between fish-eating birds and the intensive fish farming and agriculture that became established on the reclaimed land. Implementation of various deterrence methods, including lethal control, failed to solve these conflicts. We followed the concept that only by understanding the biology of the organism in question could the tools (indications) for effective and sustainable management be devised that would solve such conflicts while helping the preservation of natural assets such as wetlands and their inhabitants. We demonstrated this concept in the solutions reached in the case studies of pelicans and cormorants and their interactions with intensive commercial fish ponds. We studied the physiological condition, food preference and energy demands, and ecological constraints of Great White Pelican Pelecanus onocrotalus, Great Cormorant Phalacrocorax carbo and Pygmy Cormorant Microcarbo pygmeus. As a result, we suggested different management solutions that are currently implemented with the full cooperation of the fishermen and the nature preservation authorities. Based on assessment of visual acuity to detect and catch fish under water Great Cormorants were effectively pushed towards Lake Kinneret where they could hunt more profitable fish than in the turbid fish ponds. The established roosts there were not controlled such as to lead the birds away from the fishponds. In case of the pelicans, part of the drained Hula valley was reflooded and extra fish was provided. Both measures effectively reduced the damage at the fish farms. We have shown that such solutions are economically helpful for fishermen and enable the preservation of the wetland habitat.
Satellite Telemetry Elucidates Migratory Pathways and Foraging Areas for Hawksbill Sea Turtles, Eretmochelys imbricata, in the Caribbean

Abstract Adult female sea turtles are highly migratory, moving between foraging and nesting areas that can be thousands of kilometers apart. Conserving sea turtles and their habitats therefore depends on knowledge of space use across these migration-linked environments. Here, we describe migratory behavior of hawksbill sea turtles (Eretmochelys imbricata), a globally imperiled species. We used satellite telemetry to characterize the movements of females from nesting areas in Jamaica (n = 4) and Antigua (n = 4), West Indies, over 1998–2001. We mapped migrations and summarized space use during inter-nesting and foraging periods with kernel utilization distributions (UDs) and minimum convex polygons. Seven of eight turtles made post-nesting migrations, with paths ranging 56–1324 km in length, representing straight-line displacements of 68–1206 km. Two turtles sampled in southern Jamaica made short-range migrations within southern Jamaican waters, whereas two from northern Jamaica migrated further to foraging areas in the waters of Belize and Honduras. Three migrants sampled at Long Island, Antigua migrated to St. Eustatius, St. Kitts, and Redonda, respectively, with a fourth individual remaining resident in northeastern Antigua. Inter-nesting movements observed for three turtles produced 50% UDs ranging 12–44 km2, with centroid depths between 4–13 m. Foraging UDs for seven turtles spanned 8–111 km2 and 2–161 m in depth. Our results reveal variable migratory strategies, demonstrate international connectivity between hawksbill foraging and nesting habitats, and provide important information for Caribbean conservation efforts such as the design of protected areas or fisheries policies.
Integrating Videos with Programming Practice

There is an increasing variety of tools available to support students outside of the classroom as they learn how to program. However, broadening participation in computer science will also require these tools to reinforce inclusivity, diversity, and equity. To address these needs, two Hispanic-Serving Institutions, California State University, Chico (Chico State) and University of California, Santa Barbara (UCSB), are collaborating to produce video tutorials featuring students from historically marginalized communities. In these videos, students demonstrate uses of programming concepts in contexts that relate to their lives and interests. This experience report describes the development of the videos and associated programming practice problems. In a mixed-method observational study (n=188) of CS1 courses at the two universities, we investigated students' engagement with the videos and practice problems. Preliminary findings revealed that when the videos and practice problems were provided as separate links, students tended to watch the videos but not engage in the practice platform. Consequently, this paper also describes the development of Codewit.us, which integrates video lessons with an adaptive drill-and-practice programming interface. We found that when presented with the integrated interface, students were more likely to engage with practice in tandem with watching videos (instead of just watching videos without practice, as previously observed). The paper also describes thematic analysis of students' qualitative feedback on the videos and practice problems.
Computing Educational Programmes with more Women are more about People & less about Things

This paper analyzes materials related to educational programmes from universities that differ significantly with regards to the percentage of women studying computing. To understand this difference better, we compare two extreme cases: the educational programme with the highest percentage of women (22%) versus the one with the lowest percentage (7%) in Denmark. Following the literature showing that there exists a correlation between gender and interest in topics distributed on the ¶EOPLE --ÞINGS spectrum, we check to what extent the promotional materials and course composition can be associated more with ¶EOPLE or rather with ÞINGS. Based on data from N=150 students who rated graphic and textual promotional materials and courses on the ¶EOPLE vs ÞINGS scale, we establish the following correlation: the programme with more women appear to be oriented significantly more towards ¶EOPLE (and less towards ÞINGS ) than the programme with less women. We hypothesize that this offers a tool to "adjust'' the gender appeal of computing educational programmes with regards to both recruitment and retention.