Miracle-dz/UniFAR-FTUs huggingface dataset:
Representations and Concepts of Borders in Digital Strategy Games and Their Potential for Political Education in Geography Teaching

In Germany, 93% of young people between the ages of 10 and 18 play video games daily. Political geography, in particular popular geopolitics, have found that video games can help to establish and develop people’s understanding of geopolitics. Consequently, this affects geography education, providing both challenges and opportunities for teaching. Geography teaching is an integral part of political education as students need to understand how boundaries and territories create spaces with regards to social power and become the object of political conflict. Reflection plays a central role in understanding and deconstructing such spatial constructions. In this article, we examine representations and concepts of borders in digital strategy games and the perception and reflection of these by the players. The results provide an outlook on the potential and the challenges of digital strategy games for political education in geography lessons in secondary schools as well as for teacher training at universities. For this reason, possible approaches for education and training will be outlined on the basis of the results.
OARRR_A_228234 323..333

Didem Saygin Robyn T Domsic 1Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA; 2Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA Abstract: Systemic sclerosis (SSc) is a chronic, multisystem autoimmune disease characterized by vasculopathy, fibrosis and immune system activation. Pulmonary hypertension and interstitial lung disease account for majority of SSc-related deaths. Diagnosis of SSc-PAH can be challenging due to nonspecific clinical presentation which can lead to delayed diagnosis. Many screening algorithms have been developed to detect SSc-associated pulmonary arterial hypertension (SSc-PAH) in early stages. Currently used PAH-specific medications are largely extrapolated from IPAH studies due to smaller number of patients with SSc-PAH. In this review, we discuss the current state of knowledge in epidemiology and risk factors for development of SSc-PAH, and challenges and potential solutions in the diagnosis, screening and management of SSc-PAH.
A COMPARISON OF MACHINE LEARNING TECHNIQUES FOR ANDROID MALWARE DETECTION USING APACHE SPARK

Wide-scale popularity of Android devices has necessitated the need of having effective means for detection of malicious applications. Machine learning based classification of android applications require training and testing on a large dataset. Motivated by these needs, we provide extensive evaluation of Android applications for classification to either benign or malware applications. Using a 17-node Apache Spark cluster, we utilized seven different machine learning classifiers and applied them on the SherLock dataset one of the largest available dataset for malware detection of Android applications. From the dataset of 83 attributes, we identified 29 suitable features of applications which are related in identifying a malware. Our analysis revealed that gradient boosted trees classification mechanism provides highest precision and accuracy and lowest false positive rate in detection of malware applications. We also applied our model to develop a real-time cloud based malware detection system. This research is novel and beneficial in providing extensive evaluation using large dataset.
Tetra­kis(μ-4-chloro­benzoato)bis­[(4-chloro­benzoato)(1,10-phenanthroline)dysprosium(III)]

In the title dinuclear centrosymmetric compound, [Dy2(C7H4ClO2)6(C12H8N2)2], the DyIII atom is coordinated in a distorted square-anti­prismatic geometry by two N atoms from one bidentate chelating phenanthroline ligand and six O atoms from five 4-chloro­benzoate anions. The dinuclear mol­ecules are linked into a three-dimensional network through weak hydrogen bonds and π–π stacking inter­actions.
Alterations in White Matter Microstructure as Vulnerability Factors and Acquired Signs of Traffic Accident-Induced PTSD

It remains unclear whether white matter (WM) changes found in post-traumatic stress disorder (PTSD) patients are stress-induced or precursors for vulnerability. The current study aimed to identify susceptibility factors relating to the development of PTSD and to examine the ability of these factors to predict the course of longitudinal PTSD. Sixty two victims who had experienced traffic accidents underwent diffusion tensor imaging using a 3.0T MRI system within 2 days after their accidents. Of these, 21 were diagnosed with PTSD at 1 or 6 months using the Clinician-Administered Ptsd Scale (CAPS). Then, 11 trauma-exposed victims with PTSD underwent the second MRI scan. Compared with the victims without PTSD, the victims with PTSD showed decreased fractional anisotropy (FA) in WM of the anterior cingulate cortex, ventromedial prefrontal cortex (vmPFC), temporal lobes and midbrain, and increased mean diffusivity (MD) in the vmPFC within 2 days after the traumatic event. Importantly, decreased FA of the vmPFC in the acute phase predicted greater future CAPS scores. In addition, we found decreased FA in the insula in the follow-up scan in the victims with PTSD, which correlated with the decreased FA of the vmPFC in their baseline scan. These results suggested that the WM might have changed within 2 days after the traumatic event in the individuals who would later develop PTSD. Furthermore, decreased FA of the vmPFC could be a possible vulnerability marker predicting future development of PTSD and may provide an outcome prediction of the acquired signs.
Reproductive performance of postpartum anoestrous dairy cows treated with progesterone and oestradiol benzoate.

Abstract Extract Recent studies have shown that the anoestrous condition of post-partum dairy cows can be treated with a combination of progesterone (for 5–7 days) and oestradiol benzoate (ODB, 1 mg injected at 24 or 48 h after termination of the progesterone treatment)(1). However, published data on the performance of this anoestrus treatment programme in commercial dairy herds is limited(2). During the 1994–95 and 1995–96 breeding seasons, performance of this anoestrus treatment programme was determined in nine and six spring-calving herds, respectively. In each herd, cows that had not been detected in oestrus using the tailpainting technique by Day -7 (Day 0 = start of the breeding season) were examined per rectum by each herd owner's attending veterinarian for the presence of a palpable corpus luteum (CL) on the ovary. Cows with a palpable CL or with an enlarged or infected uterus were excluded. Throughout the trial period, anoestrous cows were managed together with the cycling cows.
12-(1,1-Dimethyl-2-propen­yl)-5,9,10-trihydr­oxy-2,2-dimethyl-2H,6H-pyrano[3,2-b]xanthen-6-one

In the title compound, C23H22O6, the xanthene ring system is essentially planar and the chromene ring is in a screw-boat conformation. Position 1 of the 1,1-dimethyl-2-propenyl substituent is coplanar with the attached ring. O—H⋯O intra­molecular hydrogen bonds are observed in the structure. The mol­ecules form centrosymmetric hydrogen-bonded dimers via weak inter­molecular C—H⋯O inter­actions. The mol­ecules are linked by inter­molecular O—H⋯O hydrogen bonds to form a one-dimensional chain along [010].
A new Barrussus Roewer, 1928 (Solifugae: Karschiidae) from southern Turkey

A new species of Barrussus, Barrussus telescopus sp. nov., is described from the Bolkar Mountains in southern Turkey. Males have an extremely elongated and bar-shaped ocular tubercule extended anteriorly between their eyes, which is the longest projecting ocular tubercule among all known males of Barrussus. The ocular tubercule of females has a short conical projection. Cheliceral movable fingers of type specimens have 5 anteriorly situated small teeth. Males have club-shaped ctenidia on the 4th and blunt-ended tubular ctenidia on the 5th opisthosomal sternites. The female has no ctenidia on its 4th opisthosomal sternite, with ctenidia on the 5th opisthosomal sternite similar to that in males. Ctenidia of the 5th opisthosomal sternite are pointed apically in the female, blunt in the male. The female possesses a hump-like projection on the metapeltidium, which is only known from females of B. telescopus sp. nov. within all known females of Barrussus. The new species is differentiated from B. pentheri (Werner, 1905) and B. furcichelis Roewer, 1928.
ブドウ'グローコールマン'果実切片のアントシアニン蓄積における紫外線の関与

The role of UV radiation in the accumulation of anthocyanin in 'Gros Colman' (Vitis vinifera L.), a light-sensitive cultivar, was examined by using berry sections prepared from the softened green berries at veraison. The sections were exposed to diffuse sunlight under covering materials such as glass plate, polyolefin film (PO), poly vinyl chloride film (PVC), UV-proof PVC, ethylenetetrafluoroethylene (ETFE), polycarbonate resin plate (PC), fiber-reinforced acrylic resin plate (FRA) for 72 hr. The accumulation of anthocyanin in the berry skins under diffuse sunlight was greatly reduced with the covering materials which prevent the penetration of UV light. Artificial irradiation with an UV lamp (peak wavelength: 352 nm) greatly promoted the accumulation of anthocyanin. With increasing light intensity in the UV-A region (320-400 nm) up to 0.4 W·m-2, the anthocyanin content markedly increased, reached a plateau and then levelled off at 2.3 W·m-2. Increasing the intensity of white light up to 8.5 W·m-2 induced a gradual accumulation of anthocyanin. When UV irradiation was combined with white light at about 4.1 W·m-2, the accumulation of anthocyanin was further enhanced. These results suggest that UV light is involved in the accumulation of anthocyanin in 'Gros Colman' grapes. Hence, UV permeability of covering materials in the protected culture should be considered.
Race, health, and disease in 19th-century-born males

This study analyzed skeletal health disparities among African American and Euro-American males of low socioeconomic status born between 1825 and 1877. A total of 651 skeletons from the Cobb, Hamann-Todd, and Terry anatomical collections were macroscopically examined for skeletal pathologies related to dietary deficiencies and disease. Individuals were separated into age, ancestry, birth (Antebellum, Civil War, Pre-Reconstruction, and Reconstruction), combined ancestry/birth, enslaved versus liberated, and collection cohorts. These groups were statistically evaluated using ANOVA and χ2 analyses to determine if age, ethnic, and temporal differences existed. Results indicated that African Americans, especially those born during Reconstruction, had significantly higher frequencies of tuberculosis (P = 0.004) and treponematosis (P = 0.006) than Euro-Americans. Historical sources are important in contextualizing why these different ethnic and temporal patterns were present, pointing to environmental conditions related to enslavement, postliberation migration to the industrialized North, crowded urban living conditions, and poor sanitation. Am J Phys Anthropol, 2011. © 2010 Wiley-Liss, Inc.
CSC-1

The Aurora B kinase complex is a critical regulator of chromosome segregation and cytokinesis. In Caenorhabditis elegans, AIR-2 (Aurora B) function requires ICP-1 (Incenp) and BIR-1 (Survivin). In various systems, Aurora B binds to orthologues of these proteins. Through genetic analysis, we have identified a new subunit of the Aurora B kinase complex, CSC-1. C. elegans embryos depleted of CSC-1, AIR-2, ICP-1, or BIR-1 have identical phenotypes. CSC-1, BIR-1, and ICP-1 are interdependent for their localization, and all are required for AIR-2 localization. In vitro, CSC-1 binds directly to BIR-1. The CSC-1/BIR-1 complex, but not the individual subunits, associates with ICP-1. CSC-1 associates with ICP-1, BIR-1, and AIR-2 in vivo. ICP-1 dramatically stimulates AIR-2 kinase activity. This activity is not stimulated by CSC-1/BIR-1, suggesting that these two subunits function as targeting subunits for AIR-2 kinase.
Cinética de fermentação in vitro de silagens da parte aérea de mandioca

The objective of this work to determine Kinetics of ruminal fermentation of silages of different fractions of the aerial parts of cassava varieties by technical semiautomatic gas production. The experiment was conducted in a completely randomized design with four replications, arranged in a 4x3 factorial design, four varieties of cassava (Amarelinha, Sabara, Olho Roxo e Periquita) and three fraction of shoots (upper, left over planting and whole plant). The material was ensiled in mini-silos of PVC, being opened after 56 days of fermentation. Silage samples were collected and submitted to pre-dried, ground and then proceeded to test gas production in vitro. The pressure readings of the gases produced during fermentations were performed at 2; 4; 6; 8; 10; 12; 15; 18; 21; 24; 30; 36; 48; 72 and 96 hours after the start of incubations. Pressure readings were made of gases through pressure transducer and subsequently adjusted to the volume of gases. The major ruminal DM disappearance occurred in times between zero and 24 hours. The highest yields of gas per hour were obtained at approximately 48 hours of fermentation for variety in Shiner fraction entire plant. The silages of different varieties and fractions of cassava shoots have the same potential for gas production. However, silage variety of Hopscotch fractions in the upper third of shoot and leftover planting have better effective degradability and potential.
Immunadsorption zur Eskalation der Schubtherapie bei Multipler Sklerose

Fragestellung: Zur Eskalation der Schubtherapie bei Multipler Sklerose (MS) ist der Plasmaaustausch (PA) eine leitliniengerechte Option, zur Immunadsorption (IA) als Alternativverfahren gibt es erst wenige Daten. Ziel war, Effektivitat und Vertraglichkeit der IA bei akutem MS-Schub zu untersuchen. Methodik: Retrospektive Analyse von 24 Patienten, Durchschnittsalter 37 Jahre (± 10 Jahre). 22 Patienten zeigten vor IA einen steroidrefraktaren MS-Schub, 2 schwangere Patientinnen mit akutem MS-Schub wurden nicht mit Steroiden behandelt. Die Patienten erhielten im Mittel 5 IA mit dem nicht regenerierbaren Tryptophan-Immunadsorber. Zielkriterium war die Besserung der Schubsymptomatik gemessen an der EDSS (Expanded Disability Status Scale). Bei Patienten mit einer Optikusneuritis wurde der Visus als Zielkriterium herangezogen. Ergebnisse: Hauptschubsymptome waren bei 18 Patienten spastische Para- oder Tetraparesen, alltagsrelevante zerebellare Ataxien oder schmerzhafte Parasthesien. Bei 12 der 18 Patienten besserte sich die EDSS um mindestens 1 Punkt nach IA, im Median von 7,0 auf 5,5 (p < 0,01). Die EDSS der schwangeren Patientinnen besserte sich von 7 auf 5,5 bzw. 6,5 auf 5,5. Sechs Patienten hatten eine Optikusneuritis. Alle 6 Patienten besserten sich im Sehvermogen um mindestens 10 % (Spanne: 10 – 90 %) nach IA. Die IA-Behandlungen wurden gut vertragen, es traten keine schwerwiegenden Nebenwirkungen auf. Schlussfolgerung: Die Tryptophan-IA erwies sich als Bestandteil des eskalierenden Therapieregimes bei steroidrefraktarem MS-Schub als sicher und effektiv, 18 von 24 Patienten verbesserten sich im Hauptsymptom ihres MS-Schubes nach IA. Bei MS-Schuben in der Schwangerschaft kann die IA ohne Steroidpuls eine Therapieoption darstellen. Im Gegensatz zum PA ist die IA ein selektives Verfahren, ohne die Notwendigkeit der Substitution von Fremdeiweisen.
Experience and Nursing Support for the People with Unruptured Intracranial Aneurysms-Daily Experiences through a Wait-and-See Approach-

目的：本研究は未破裂脳動脈瘤に対し自然経過観察を選択した人々の生活体験を明らかにし看護支援への示唆を得ることを目的とした．方法：現象学的アプローチを用いて，未破裂脳動脈瘤を1年以上経過観察している人々を対象に非構造化面接調査を実施した．データ分析にはGiorgiの分析方法を用いた．結果：17名の対象者から得られた質的データ分析の結果，21の本質的要素が抽出された．それらはさらに（1）診断・療養体験（2）対処・生活再構築（3）瘤と共に生きる，の3側面に分けられた．対象者は『拭い去れない不安感』を抱えながらも『少しずつ生活範囲を拡大する』『破裂のリスクを最小限にする』などのさまざまな対処を経て，最終的に『時と共に積み重なる自信と確証』を得ていた．また瘤と共に生きる側面は，『瘤を自分なりに捉え直す』『肯定的側面に目を向ける』『瘤との適度な距離を知り保つ』の3局面をたどっていた．結論：予防行動と不安のバランス保持，捉え直しと肯定的側面への気付き，瘤との適度な距離の理解などの看護支援を併せたフォローアップを行うことが必要であることが示唆された．
Association between Suicidal Ideation and Causes of Primary Care Visits: A Cross-Sectional Study to Identify Patients with Suspected Suicidal Ideation

Objective Suicide victims are likely to visit a primary care provider within 1 month of the suicide attempt. However, it is impossible for primary care providers to screen all patients for suicidal ideation or attempts. We, therefore, aimed to investigate potential differences in the chief diagnoses received by primary care patients with and without suicidal ideation, as this information may provide clues and predict patients at risk of suicide. Methods This cross-sectional study included 1,211 Korean adults aged ≥20 years who had participated in the Korea National Health and Nutrition Examination Survey during 2014 and provided information about their histories of suicidal ideation and visits to primary care providers. Multiple logistic regression analyses were used to examine whether suicidal ideation was associated with specific diseases after controlling for age, sex, household income, education, occupation, marital status, smoking, alcohol consumption, and physical activity. Results Among primary care patients, the sample-weighted percentage of suicidal ideation was approximately 12%. The diagnoses of neoplasm and mental disorder were associated with a higher likelihood of suicidal ideation {odds ratio (OR) [95% confidence interval (CI)] 8.32 (1.01–68.56) and 6.19 (1.72–22.33), respectively}. Notably, diseases of the musculoskeletal system and connective tissue were also associated with suicidal ideation [OR (95% CI): 1.93 (1.09–3.43)]. Conclusion The observed visit patterns and correlations of certain diagnoses with suicidal ideation suggest that primary care physicians should pay attention to patients with relevant disorders, consider screening suicidal ideation, and properly consult to a psychiatrist.
Differential Effects of Gefitinib and Cetuximab on Non–small-cell Lung Cancers Bearing Epidermal Growth Factor Receptor Mutations

BACKGROUND Many patients with non-small-cell lung cancer (NSCLC) who achieve radiographic responses to treatment with the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors gefitinib and erlotinib have somatic mutations in the EGFR tyrosine kinase domain. However, little is known about the efficacy of cetuximab, an antibody against the EGFR extracellular domain, in EGFR mutant NSCLC. METHODS NSCLC cell lines carrying wild-type EGFR (A549, H441, and H1666) or mutant EGFR (H3255, DFCILU-011, PC-9, and HCC827) were treated with various dilutions of gefitinib or cetuximab relative to maximal achievable serum concentration. Cell growth was analyzed by the MTS assay, with differences between dose-response curves analyzed nonparametrically. Apoptosis was analyzed by propidium iodide staining and immunoblotting for PARP. Phosphorylation of EGFR and the downstream signaling components ERK1/2 and Akt were analyzed by immunoblotting. Statistical tests were two-sided. RESULTS Growth of NSCLC lines with wild-type EGFR was slightly (A549 and H441) or moderately (H1666) inhibited by gefitinib and cetuximab, and the effects of the two agents were similar. Both agents also induced no (H441) or moderate (H1666) apoptosis in NSCLC cells with wild-type EGFR. By contrast, gefitinib was statistically significantly more effective than cetuximab at inhibiting growth of EGFR mutant cells (H3255: P = .003, DFCILU-011: P = .011, and PC-9: P = .003), and gefitinib-treated EGFR mutant cells had higher levels of apoptosis than cetuximab-treated cells (mean fold increase in apoptosis by 1 microM of gefitinib and 10 microg/mL of cetuximab relative to control, H3255: 8.3 [95% confidence interval {CI} = 4.8 to 11.8] and 2.1 [95% CI = 2.0 to 2.2], respectively, P = .025; DFCILU-011: 5.7 [95% CI = 5.1 to 6.3] and. 0.9 [95% CI = 0.3 to 1.5], respectively, P < .001). Gefitinib treatment decreased EGFR, ERK1/2, and Akt phosphorylation in EGFR mutant cell lines whereas cetuximab had relatively little effect. Both gefitinib and cetuximab inhibited the growth of HCC827 cells, but gefitinib inhibited growth to a greater extent (P = .003). CONCLUSIONS EGFR mutations in NSCLC cells are associated with sensitivity to gefitinib but not to cetuximab.
Selective Inhibition of Pyrimidine Biosynthesis and Effect on Proliferative Growth of Colonic Cancer Cells

Summary A highly selective inhibition of de novo pyrimidine synthesis in the intact cell has been demonstrated by the action of N -(phosphonacetyl)-l-aspartate (PALA), a transition-state analog inhibitor of the reaction catalyzed by asparate transcarbamylase. The effect of pyrimidine deprivation induced by this agent on the viability and survival of human normal (WI-38) and colonic cancer cells (HT-29) was examined. The PALA-treated, pyrimidine-deprived cells failed to grow but demonstrated a normal rate of glucose utilization with impaired glycogen synthesis. Pyrimidine deprivation and lack of cell growth were maintained long after PALA removal. Growth inhibition of HT-29 cells by PALA was found to reflect an apparent steady state between newly formed and dying cells induced by limited pyrimidine availability. The highly selective nature of PALA action was confirmed by the ability of an exogenous source of pyrimidine to restore the normal growth pattern of the cell. Significant antitumor activity by PALA was found against a transplantable colonic tumor (line 26) carried in mice.
Thrombocytopenia and Low Molecular Weight Heparin in the Parturient: Implications for Neuraxial Anesthesia

Neuraxial analgesia is routinely administered to the parturient. A devastating, albeit rare, complication of neuraxial anesthesia is spinal or epidural hematoma, and primarily occurs in patients with disorders of hemostasis. A parturient with a clinically active coagulation disorder or someone with a history of easy bruising and/or bleeding is considered to have an absolute contraindication to regional anesthesia. However, many areas of controversy exist. The concern most anesthesiologists have regarding thrombocytopenia is determining the lowest platelet count at which it is still safe to perform a neuraxial anesthetic technique. In addition, an increasing number of women are receiving anticoagulant medications during pregnancy and low molecular weight heparin (LMWH) is a commonly used agent. The role of platelets in the coagulation process, the most common disorders in pregnancy that lead to thrombocytopenia, and the laboratory tests available to assess platelet function will be reviewed and practical recommendations provided as to the anesthetic management of the parturient with thrombocytopenia and one who is taking LMWH.
2,4-Dibenzoyl-3,5-bis(4-methoxylphenyl)-1-phenylcyclohexanol

The title compound, C40H36O5, was synthesized from p-anisaldehyde and acetophenone. The central six-membered ring adopts a chair conformation and most of the bulky side groups are located in equatorial positions. The hydroxyl group is involved in weak intra- and inter­molecular hydrogen bonding.