Miracle-dz/UniFAR-FTUs huggingface dataset:
Constrained Approximate Subtree Matching by Finite Automata

Processing tree data structures usually requires a pushdown automaton as a model of computation. Therefore, it is interesting that a ﬁnite automaton can be used to solve the constrained approximate subtree pattern matching problem. A systematic approach to the construction of such matcher by ﬁnite automaton, which reads input trees in preﬁx bar notation, is presented. Given a tree pattern and an input tree with m and n nodes, respectively, the nondeterministic ﬁnite automaton for the pattern is constructed and it is able to ﬁnd all occurrences of the pattern to subtrees of the input tree with maximum given distance k . The distance between the pattern and subtrees of an input tree is measured by minimal number of restricted tree edit operations, called leaf nodes edit operations. The corresponding deterministic ﬁnite automaton ﬁnds all occurrences in time O ( n ) and has O ( | A | k m k +1 ) states, where A is an alphabet containing all possible node labels. Note that the size is not exponential in the number of nodes of the tree pattern but only in the number of errors. In practise, the number of errors is expected to be a small constant that is much smaller than the size of the pattern. To achieve better space complexity, it is also shown how dynamic programming approach can be used to simulate the nondeterministic automaton. The space complexity of this approach is O ( m ), while the time complexity is O ( mn ).
The Myth of Epistemic Implicata

Quite a few scholars claim that many implicata are propositions about the speaker’s epistemic or doxastic states. I argue, on the contrary, that implicata are generally non-epistemic. Some alleged cases of epistemic implicature are not implicatures in the first place because they do not meet Grice’s non-triviality requirement, and epistemic implicata in general would infringe on the maxim of quantity. Epistemic implicatures ought to be construed as members of a larger family of implicature-like phenomena.
Biomechanical Comparison of Fixation Stability among Various Pedicle Screw Geometries: Effects of Screw Outer/Inner Projection Shape and Thread Profile

The proper screw geometry and pilot-hole size remain controversial in current biomechanical studies. Variable results arise from differences in specimen anatomy and density, uncontrolled screw properties and mixed screw brands, in addition to the use of different tapping methods. The purpose of this study was to evaluate the effect of bone density and pilot-hole size on the biomechanical performance of various pedicle screw geometries. Six screw designs, involving three different outer/inner projections of screws (cylindrical/conical, conical/conical and cylindrical/cylindrical), together with two different thread profiles (square and V), were examined. The insertional torque and pullout strength of each screw were measured following insertion of the screw into test blocks, with densities of 20 and 30 pcf, predrilled with 2.7-mm/3.2-mm/3.7-mm pilot holes. The correlation between the bone volume embedded in the screw threads and the pullout strength was statistically analyzed. Our study demonstrates that V-shaped screw threads showed a higher pullout strength than S-shaped threads in materials of different densities and among different pilot-hole sizes. The configuration, consisting of an outer cylindrical shape, an inner conical shape and V-shaped screw threads, showed the highest insertional torque and pullout strength at a normal and higher-than-normal bone density. Even with increasing pilot-hole size, this configuration maintained superiority.
Characteristics of ash, maple, yew/juniper, and willow pollen seasons in the air of Kielce in 2021 in correlation with weather conditions

The paper presents the course of ash, maple, yew, juniper, and willow pollen seasons in the city of Kielce in 2021. These are the first published aerobiological studies of these species from this city. The investigations were carried out with the volumetric method using a Lanzoni apparatus. The pollen season was determined with the method of 98% of the annual pollen grain sum. In Kielce, the highest concentrations of ash pollen (85 P/m3 of air) were recorded on April 21, maple pollen (71 P/m3) on April 28, yew and juniper pollen (120 P/m3) on April 1, and willow pollen (66 P/m3) on May 12. The parameters of the pollen season were analyzed statistically with reference to the selected meteorological parameters.
Utility of Restaging MRI Following Neoadjuvant Chemoradiotherapy for Stage II-III Rectal Adenocarcinoma

Background Magnetic resonance imaging (MRI) is currently utilized for the pretreatment staging of locally advanced rectal cancer; however, there is no consensus regarding the utility of repeat MRI for restaging following neoadjuvant chemoradiotherapy (CRT). In this study, we aimed to investigate the clinical utility of restaging MRI after CRT in patients with clinical stage II-III rectal cancer. Methodology We performed a retrospective observational study at a tertiary care hospital. Our study population included patients with clinical stage II-III rectal cancer treated with neoadjuvant CRT who underwent both pre- and post-CRT MRI followed by surgical resection from 2012 to 2017. MRIs were reviewed by radiologists with an interest in rectal cancer MRI imaging using a standardized template. The utility of post-CRT MRI was evaluated by assessing its impact on change in surgical planning, concordance with pathologic staging, and prediction of surgical margins. Results A total of 30 patients were included in the study; 67% had clinical stage III and 33% had stage II disease based on pre-CRT MRI. Post-CRT MRI findings did not lead to a change in the originally outlined surgical plan in any patient. Compared to pre-CRT MRI, post-CRT MRI was not significantly more accurate in predicting T stage (k = 0.483), N stage (k = 0.268), or positive surgical margins (k = 0.839). Conclusions Due to poor concordance with pathologic staging, inability to more accurately predict surgical margin status and the absence of a demonstrable change in surgical treatment, post-CRT restaging with MRI, in its current form, appears to be of limited clinical utility.
Prevalence of Intimate Partner Violence, Substance Use Disorders and Depression among Incarcerated Women in Lima, Perú

Background: Globally, there is evidence supporting the co-occurrence of intimate partner violence (IPV), substance use disorders (SUD) and mental health disorders among women in prisons, however, there is limited research investigating these domains in the Andean region where rates of female incarceration have increased. The study objective was to explore the prevalence of IPV, SUD and depression among incarcerated women in a Peruvian prison and explore associations among these variables and related correlates. Methods: 249 incarcerated women responded to a questionnaire about IPV, substance use, depression, and sexual behavior, and were screened for HIV/sexually transmitted diseases (STDs). Univariate analysis and logistic regression were used to estimate relative risk and the influence of substance use and depression on IPV rates. Results: Twelve months prior to incarceration, of the women with sexual partners pre-incarceration (n = 212), 69.3% experienced threats of violence, 61.4% experienced ≥1 acts of physical violence, and 28.3% reported ≥1 act of sexual aggression. Pre-incarceration, 68.1% of drug-using women had a SUD, and 61.7% of those who consumed alcohol reported hazardous/harmful drinking. There were 20 (8.0%) HIV/STD cases; and 67.5% of the women reported depressive symptoms. Compared to women with no experiences of physical violence, a greater proportion of women who experienced least l violent act had depressive symptoms and engaged in sex work pre-incarceration. Depression was associated with physical violence (adjusted relative risk = 1.35, 95% confidence interval: 1.14–1.58). Recommendations: The findings provide evidence of a syndemic of IPV, substance abuse and depression among incarcerated women in a Peruvian prison. To help guide policy makers, further research is needed to determine if this is indicative of trends for other at-risk women in the region, and viable options to treat these women during incarceration to prevent recidivism and other long-term negative sequalae.
Team NCTU: Toward AI-Driving for Autonomous Surface Vehicles - From Duckietown to RobotX

Robotic software and hardware systems of autonomous surface vehicles have been developed in transportation, military, and ocean researches for decades. Previous efforts in RobotX Challenges 2014 and 2016 facilitates the developments for important tasks such as obstacle avoidance and docking. Team NCTU is motivated by the AI Driving Olympics (AI-DO) developed by the Duckietown community, and adopts the principles to RobotX challenge. With the containerization (Docker) and uniformed AI agent (with observations and actions), we could better 1) integrate solutions developed in different middlewares (ROS and MOOS), 2) develop essential functionalities of from simulation (Gazebo) to real robots (either miniaturized or full-sized WAM-V), and 3) compare different approaches either from classic model-based or learning-based. Finally, we setup an outdoor on-surface platform with localization services for evaluation. Some of the preliminary results will be presented for the Team NCTU participations of the RobotX competition in Hawaii in 2018.
Dapagliflozin Attenuates Hyperglycemia Related Osteoporosis in ZDF Rats by Alleviating Hypercalciuria

Recent studies showed that in patients with type 2 diabetes mellitus (T2DM), Sodium-dependent glucose transporters 2 inhibitor (SGLT2I) may cause potential adverse effects on skeleton such as increasing the risk of fracture. This risk is possibly mediated by effects induced by all SGLT2I class drugs but whether Dapagliflozin aggravates osteoporosis in patients with T2DM remains controversial. Therefore, we designed this study to explore how Dapagliflozin affects the metabolism and the quality of bone in. T2DM animal models The effect of Dapagliflozin on skeleton was evaluated on male ZDF (Zucker Diabetic Fatty) rats—a rat model of diet induced spontaneous T2DM. Dapagliflozin was administrated via gavage at the dosage of 1.0 mg/kg/day. Bone tissue mineral density and the microarchitecture of tibiae were measured with micro-CT and biomechanics characteristic of the femora were tested using a three-point bending test. Serum bone biomarkers and other metabolic parameters were also tested via ELISA or other assays. Our results found that diabetic rats demonstrated symptoms of osteoporosis and Dapagliflozin could help to alleviate these defections caused by diabetes. Compared to the negative controls, the serum CT (calcitonin) level in ZDF rats as well as the uric calcium and phosphate levels were elevated, and these symptoms were alleviated by Dapagliflozin. Tibiae of Dapagliflozin treated rats demonstrated decreased cortical tissue mineral density while trabecular tissue mineral density and mean bone mineral density received a rise when compared to the matched controls. ZDF rats also showed defections in femora stiffness which could be relieved by Dapagliflozin administration. The mechanism of Dapagliflozin affecting bone quality is possibly connected to the suppression of serum calcitonin and excretion of calcium via urine rose by hyperglycemia. In conclusion, Dapagliflozin can prevent osteoporosis in ZDF rats by alleviating hypercalciuria.
Structural and Functional Determinants of Rodent and Human Surfactant Protein A: A Synthesis of Binding and Computational Data

Surfactant protein A (SP-A) provides surfactant stability, first line host defense, and lung homeostasis by binding surfactant phospholipids, pathogens, alveolar macrophages (AMs), and epithelial cells. Non-primates express one SP-A protein whereas humans express two: SP-A1 and SP-A2 with core intra- and inter-species differences in the collagen-like domain. Here, we used macrophages and solid phase binding assays to discern structural correlates of rat (r) and human (h) SP-A function. Binding assays using recombinant rSP-A expressed in insect cells showed that lack of proline hydroxylation, truncations of amino-terminal oligomerization domains, and site-directed serine (S) or alanine (A) mutagenesis of cysteine 6 (C6S), glutamate 195 (E195A), and glutamate 171 (E171A) in the carbohydrate recognition domain (CRD) all impaired SP-A binding. Replacement of arginine 197 with alanine found in hSP-A (R197A), however, restored the binding of hydroxyproline-deficient rSP-A to the SP-A receptor SP-R210 similar to native rat and human SP-A. In silico calculation of Ca++ coordination bond length and solvent accessibility surface area revealed that the “humanized” R197A substitution alters topology and solvent accessibility of the Ca++ coordination residues of the CRD domain. Binding assays in mouse AMs that were exposed to either endogenous SP-A or hSP-A1 (6A2) and hSP-A2 (1A0) isoforms in vivo revealed that mouse SP-A is a functional hybrid of hSP-A1 and hSP-A2 in regulating SP-A receptor occupancy and binding affinity. Binding assays using neonatal and adult human AMs indicates that the interaction of SP-A1 and SP-A2 with AMs is developmentally regulated. Furthermore, our data indicate that the auxiliary ion coordination loop encompassing the conserved E171 residue may comprise a conserved site of interaction with macrophages, and SP-R210 specifically, that merits further investigation to discern conserved and divergent SP-A functions between species. In summary, our findings support the notion that complex structural adaptation of SP-A regulate conserved and species specific AM functions in vertebrates.
Drug Resistance Characteristics of Mycobacterium tuberculosis Isolates From Patients With Tuberculosis to 12 Antituberculous Drugs in China

Objective: To investigate the drug resistance characteristics of Mycobacterium tuberculosis (MTB) isolates from patients with tuberculosis to 12 antituberculous drugs in China. Methods: All clinical isolates of MTB were isolated from patients with tuberculosis in Shanghai Pulmonary Hospital (SPH) during the period from January 1st to December 31th, 2018. Drug susceptibility testing (DST) was performed in micro plates with 12 antituberculous drugs in accordance with relevant guideline. Demographic information, including sex, age, and treatment history was recorded. Results: A total of 1,950 MTB isolates were included in this retrospective study which were isolated from 1,950 patients from 29 regions in China. One thousand six hundred and forty-four were initial treated and 306 were re-treated in the hospital. Two hundred and eight (10.67%, 208/1,950) cases were diagnosed as multidrug-resistant tuberculosis (MDR-TB), from which 74 (4.50%, 74/1,644) cases were initial treated, and the remaining (43.79%, 134/306) were re-treated cases. Besides, the percentage of extensively drug-resistant tuberculosis (XDR-TB) varied in such 3 different groups: 1.64% (32/1,950) in total cases, 0.30% (5/1,644) in initial treated cases and 8.82% (27/306) in re-treated cases. The total resistance rates were as follows: isoniazid (361, 18.51%), streptomycin (302, 15.49%), rifampin (241, 12.36%), ofloxacin (239, 12.26%), moxifloxacin (232, 11.90%), rifabutin (195, 10.00%), ethambutol (100, 5.13%), cycloserine (55, 2.82%), kanamycin (48, 2.46%), ethionamide (40, 2.05%), amikacin (39, 2.00%), and aminosalicylic acid (21, 1.08%). Rates of resistance to any drug in re-treated cases were significantly higher than in initial treated cases. The drug resistance rates of the 12 drugs were higher in males than in females. Patients older than 60 years had significantly lower percentages of MDR/XDR-TB (7.11 and 0.65%) than in younger age groups. The proportion of re-treated cases in Shanghai (11.38%, 88/773) was lower than that in other regions. Meanwhile, the percentages of MDR/XDR-TB in Shanghai (4.79 and 0.65%) were significantly lower than in other regions. Conclusions: In this study, we found higher proportion of MDR/XDR-TB among re-treated cases than initial treated cases in China and the drug resistance rate of tuberculosis varied with age, sex, and region, indicating that standardized anti-tuberculosis treatment can reduce the incidence of drug-resistant tuberculosis and the recurrence of tuberculosis.
Effects of Local Vibration With Different Intermittent Durations on Skin Blood Flow Responses in Diabetic People

Objective: Poor blood flow supply is an important pathological factor that leads to the development and deterioration of diabetic foot ulcers. This study aims to investigate the acute effects of local vibration with varying intermittent durations on the plantar skin blood flow (SBF) response in diabetic and healthy subjects. Methods: Eleven diabetic patients (7 males, 4 females) and 15 healthy adults (6 males, 9 females) participated in this experiment and accepted three tests. Local continuous vibration (LCV) and two levels of local intermittent vibration (LIV1 and LIV2) were randomly applied to the middle metatarsal head of each subject's right foot in each test. The SBF was measured prior to intervention (Baseline), during Vibration and during the Recovery Stage for each test. The mean SBF in each stage, the change percentages and change rates of SBF in Vibration and Recovery stage among three tests were compared and analyzed for both diabetic and healthy subjects. Results: For diabetic subjects, the SBF was significantly increased in both Vibration and Recovery Stage with local intermittent vibrations (LIV1 and LIV2), but not with LCV. However, there was no significant difference in change percentage and change rate of SBF in diabetic subjects across the three tests. For healthy subjects, all vibration interventions significantly increased the SBF in the Vibration Stage and in the first 1.5 min of the Recovery Stage. Also, the change rate of SBF during the Vibration stage in LIV1 test was significantly greater than that in LIV2 test for healthy subjects. Moreover, change percentage of SBF in Vibration stage of LIV1 test and in some periods of Recovery stages of LIV1 and LIV2 tests for diabetic subjects were lower than for healthy subjects; the absolute change rate of SBF in LIV1 test for diabetic subjects was also lower than for healthy subjects. Conclusion: These findings suggest that both LIV1 and LIV2 may effectively improve SBF in the feet of diabetic people, but LCV may not achieve the same level of vasodilatation. The diabetic subjects were also found to have a lower SBF response to applied vibration than the healthy subjects.
Persistence and Accumulation of Visual Memories for Objects in Scenes in 12-Month-Old Infants

Visual memory for objects has been studied extensively in infants over the past 20 years, however, little is known about how they are formed when objects are embedded in naturalistic scenes. In adults, memory for objects in a scene show information accumulation over time as well as persistence despite interruptions (Melcher, 2001, 2006). In the present study, eye-tracking was used to investigate these two processes in 12-month-old infants (N = 19) measuring: (1) whether longer encoding time can improve memory performance (accumulation), and (2) whether multiple shorter exposures to a scene are equivalent to a single exposure of the same total duration (persistence). A control group of adults was also tested in a closely matched paradigm (N = 23). We found that increasing exposure time led to gains in memory performance in both groups. Infants were found to be successful in remembering objects with continuous exposures to a scene, but unlike adults, were not able to perform better than chance when interrupted. However, infants’ scan patterns showed evidence of memory as they continued the exploration of the scene in a strategic way following the interruption. Our findings provide insight into how infants are able to build representations of their visual environment by accumulating information about objects embedded in scenes.
The Predictors of Consumer Behavior in Relation to Organic Food in the Context of Food Safety Incidents: Advancing Hyper Attention Theory Within an Stimulus-Organism-Response Model

Despite the rapid development of China’s organic food industry in recent years, the market size of this industry remains relatively small. Since the organic food market started late in China, consumer groups are mainly concentrated in large cities at present. It is, therefore, urgent to take effective measures to promote the development of China’s organic food market. The current study focuses on the direct and indirect relationships between food safety incidents and organic food purchases by considering the Chinese context, using stimulus-organism-response model and information use environment theory, and introducing a hyper attention cognitive model. The results show that external stimulus (food safety incidents) and internal stimulus (consumer environment orientation) can significantly affect consumers’ response (namely, consumer organic cognition), and the enhancement of consumer organic cognition can promote consumer organic purchase. In addition, consumers’ information environment (the information relating to food safety incidents and environment) can significantly affect their organic food purchase. Moreover, food safety incidents can attract consumers’ hyper attention and thus has a positive impact on consumers’ cognition of organic food. These findings have important implications for research and practice.
Multimodal Integration of Brain Images for MRI-Based Diagnosis in Schizophrenia

Magnetic resonance imaging (MRI) has been proposed as a source of information for automatic prediction of individual diagnosis in schizophrenia. Optimal integration of data from different MRI modalities is an active area of research aimed at increasing diagnostic accuracy. Based on a sample of 96 patients with schizophrenia and a matched sample of 115 healthy controls that had undergone a single multimodal MRI session, we generated individual brain maps of gray matter vbm, 1back, and 2back levels of activation (nback fMRI), maps of amplitude of low-frequency fluctuations (resting-state fMRI), and maps of weighted global brain connectivity (resting-state fMRI). Four unimodal classifiers (Ridge, Lasso, Random Forests, and Gradient boosting) were applied to these maps to evaluate their classification accuracies. Based on the assignments made by the algorithms on test individuals, we quantified the amount of predictive information shared between maps (what we call redundancy analysis). Finally, we explored the added accuracy provided by a set of multimodal strategies that included post-classification integration based on probabilities, two-step sequential integration, and voxel-level multimodal integration through one-dimensional-convolutional neural networks (1D-CNNs). All four unimodal classifiers showed the highest test accuracies with the 2back maps (80% on average) achieving a maximum of 84% with the Lasso. Redundancy levels between brain maps were generally low (overall mean redundancy score of 0.14 in a 0–1 range), indicating that each brain map contained differential predictive information. The highest multimodal accuracy was delivered by the two-step Ridge classifier (87%) followed by the Ridge maximum and mean probability classifiers (both with 85% accuracy) and by the 1D-CNN, which achieved the same accuracy as the best unimodal classifier (84%). From these results, we conclude that from all MRI modalities evaluated task-based fMRI may be the best unimodal diagnostic option in schizophrenia. Low redundancy values point to ample potential for accuracy improvements through multimodal integration, with the two-step Ridge emerging as a suitable strategy.