Miracle-dz/UniFAR-FTUs huggingface dataset:
Yunvjian-Medicated Serum Protects INS-1 Cells against Glucolipotoxicity-Induced Apoptosis through Autophagic Flux Modulation

Yunvjian (YNJ) is a traditional Chinese medicine formula adopted to prevent and treat diabetes. Our previous results from animal experiments showed that YNJ decreased blood glucose. This study aimed to examine the effect of high glucose and high lipid (HG/HL) conditions on the proliferation and apoptosis of INS-1 cells and the possible protective mechanism of YNJ-medicated serum on INS-1 cells exposed to HG/HL conditions. INS-1 cells were cultured in RPMI 1640 medium after being passaged. Then, INS-1 cells in the logarithmic growth phase were collected and divided into five groups: control, HG/HL, HG/HL+5% YNJ-medicated serum, HG/HL+10% YNJ-medicated serum, and HG/HL+20% YNJ-medicated serum. MTT assay and flow cytometry were used to detect proliferation and apoptosis of INS-1 cells, respectively. Protein profiles of INS-1 cells were analyzed using a tandem mass tag (TMT) label-based quantitative proteomic approach. Western blotting was performed to verify the proteomic results. YNJ-medicated serum significantly promoted INS-1 cell proliferation and inhibited apoptosis. Proteomic results from the INS-1 cells in the control, HG/HL, and HG/HL+10% YNJ-medicated serum groups showed that 7,468 proteins were identified, of which 6,423 proteins were quantified. Compared with the HG/HL group,430 differential proteins were upregulated, and 671 were downregulated in the HG/HL+10% YNJ-medicated serum group. Compared with the control group, 711 differential proteins were upregulated and 455 were downregulated in the HG/HL group, whereas 10 differential proteins were upregulated and 9 were downregulated in the HG/HL+10% YNJ-medicated serum group. Furthermore, several proteins related to autophagy, including ATG3, ATG2B, GABARAP, WIPI2, and p62/SQSTM1, were verified by western blotting, and these results were consistent with the results obtained from the proteomics analysis. These results confirmed that the autophagy pathway is critical to glucolipotoxicity in INS-1 cells. YNJ-medicated serum exhibited a protective effect on INS-1 cells cultured under HG/HL conditions by regulating autophagy genes' expression and restoring the autophagic flux.
Intention as a Mediator between Attitudes, Subjective Norms, and Cyberloafing among Preservice Teachers of English

Accepted: 18.11. 2020 Learning and teaching is fostered to a great deal by technology. Cell phones and internet can be utilized as effective tools in providing extended and diversified learning opportunities as well as promoters of learning and teaching. However, early internet-enabled cell phones or more recent smartphones have also become easily accessible avenues of distraction and escape. This study explored if and how intention to cyberloaf acts as a mediator in the relationship between attitudes, subjective norms, and cyberloafing with a focus on descriptive and prescriptive norms with respect to instructors and classmates separately. The research was undertaken at a foundation university in Ankara, Turkey with 214 preservice English teachers. The sample consisted of 152 (71.03%) females and 62 (28.97%) males. Cyberloafing scale developed by Kalaycı (2010), adapted versions of Askew et al.’s (2014) attitudes towards cyberloafing scale, subjective descriptive norms scale, cyberloafing intentions scale, and Blanchard and Henle’s (2008) norms scale were used as data collection instruments. Mediation analyses were performed using SPSS 22 with the utilization of SPSS macro, PROCESS v 3.4 (Hayes, 2017). The results of the regression analyses indicated that subjective norms and attitudes significantly predicted cyberloafing; and intentions to cyberloaf was found to be a significant but partial mediator between the variables. The results have significant implications both for academic research on cyberloafing and for educational practices.
REMOTE SETTING OF Nodipecten nodosus (Linnaeus 1758) LARVAE

The present study aimed to evaluate the growth and survival of Nodipecten nodosus larvae grown in a remote settlement system. Two forms of transport were tested, one in a humid/wet, environment and one submerged in seawater, with a control treatment maintained at the Laboratory of Marine Mollusks (LMM). After transport treatments, individuals were populated simultaneously inside floating boxes directly at sea and in containers under controlled conditions in the Laboratory of the Experimental Center for Mariculture (CEMAR). No statistical differences were observed in larval survival relative to the method of transport in the different experiments. However, statistical differences were observed in evaluation 1 (EVA1) for the survival and growth of larvae transported in submerged seawater and settled in the laboratory. No statistical difference was observed between the control and either wet/humid or submerged treatments in EVA2. The survival values in the control treatment in EVA3 were higher (p<0.05) in relation to the wet and submerged treatments cultivated in the laboratory. It was not possible to observe the presence of pre-seeds in treatments grown at sea. Is possible to transport larvae for 6 hours of travel to be settled in controlled conditions far from their place of origin.
Local Energy Projects on Islands: Assessing the Creation and Upscaling of Social Niches

Islands have great potential for renewable energy, and several pilot and experimental projects have been set up on islands globally, aiming to promote clean energy and self-sufficiency. Many of these decentralized energy initiatives oppose the established regimes of centralized electricity generation and introduce new forms of organization and management. Thus, they can be considered social niches. The aim of the present study is to explore the transition potential of renewable energy projects on three islands located in southern Europe. The analysis mobilizes literature on the strategic niche management theory (SNM) with a focus on the role of the various actors and the different management models. Through a systematic analysis of policy documents and the literature, enriched by interviews, the paper identifies different types of renewable energy projects and discusses the potential for scale up. The paper concludes that these projects are currently in the inter-local phase, and decentralization is not only an important innovation for energy production, but also a new form of energy management often dominated by different actors than the established electricity system.
Electrodeposition of Pt-Decorated Ni(OH)2/CeO2 Hybrid as Superior Bifunctional Electrocatalyst for Water Splitting

The facile synthesis of highly active and stable bifunctional electrocatalysts to catalyze water splitting is attractive but challenging. Herein, we report the electrodeposition of Pt-decorated Ni(OH)2/CeO2 (PNC) hybrid as an efficient and robust bifunctional electrocatalyst. The graphite-supported PNC catalyst delivers superior hydrogen evolution reaction (HER) and oxygen evolution reaction (OER) activities over the benchmark Pt/C and RuO2, respectively. For overall water electrolysis, the PNC hybrid only requires a cell voltage of 1.45 V at 10 mA cm−2 and sustains over 85 h at 1000 mA cm−2. The remarkable HER/OER performances are attributed to the superhydrophilicity and multiple effects of PNC, in which Ni(OH)2 and CeO2 accelerate HER on Pt due to promoted water dissociation and strong electronic interaction, while the electron-pulling Ce cations facilitate the generation of high-valence Ni OER-active species. These results suggest the promising application of PNC for H2 production from water electrolysis.
¿“Crowdfunding” como finanzas democráticas? Comprender cómo y por qué los inversores del Reino Unido confían en estos mercados

¿Puede el crowdfunding contribuir al reequilibrio del sistema financiero mediante la democratización de la inversión? Este documento comienza a responder a esta pregunta estableciendo cómo y por qué los inversores confían en estos mercados. Ofrecemos dos contribuciones. Primero, a los debates teóricos sobre finanzas democráticas; y segundo, a un cuerpo más empírico de investigación interdisciplinar sobre inversión popular a través de un análisis cualitativo de 52 entrevistas originales con inversores en seis mercados de crowdfunding del Reino Unido. Nuestros datos se toman de un proyecto con la Autoridad de Conducta Financiera del Reino Unido para mejorar la protección de los inversores en estos mercados. Utilizando un enfoque de sociología económica, encontramos que los inversores: movilizan redes integradas para establecer confianza en el crowdfunding; están motivados por las expectativas de «rendimientos combinados»; prefieren herramientas de inversión automatizadas si carecen de experiencia; y típicamente invierten con fondos que han destinado a perder. Concluimos que se requiere una mayor protección de los inversores para la financiación colectiva para ayudar a democratizar las finanzas
Experimental study of copper toxicity and some stress biomarkers in Macrobrachium scabriculum (Heller, 1862)

ABSTRACT A laboratory experiment on copper toxicity in Macrobrachium scabriculum or Chameleon shrimp was performed to understand the adverse effect of copper sulfate, commonly used as antiparasitic medication against Ichthyophthirius multifilis or Ick. Mortality rate was observed to be over 80% at dosage of 5 µM and above, equivalent to about 0.32 mg.L−1 or higher of ionic copper. The species exhibited a greater resistance against copper toxicity than many other shrimp/prawn species as its survivability was quite high even under relatively higher copper concentrations. The LC50 value after 168 h of exposure was 3.12 ± 0.13 µM of copper sulfate or 0.78 ± 0.25 mg.L−1 in terms of Cu2+. Lipid peroxidation activity along with catalase and superoxide dismutase was selected as oxidative stress biomarkers. All the three biomarkers appeared to be more or less equally responsive to the stress level. One-way ANOVA performed on the data set ensured the statistical significance of the data with the rejection of null.
The Value of Handwritten Notes: A Failure to Find State-Dependent Effects When Using a Laptop to Take Notes and Complete a Quiz

Background: Many students use laptops in the classroom to take notes; however, even when laptops are used for the sole purpose of taking notes they can negatively impact academic performance. Objective: The current study examined state-dependent effects, and the potential for a match in note taking and quiz taking methods to improve quiz performance. Method: Participants were placed into a congruent (take notes by hand and complete the quiz by hand or take notes using a laptop and complete an online quiz) or an incongruent condition (take notes by hand and take an online quiz or take notes using a laptop and complete the quiz by hand). Results: The results revealed that participants who took notes by hand performed better on the quiz overall, and better on conceptual questions, then students who took notes using a laptop. We failed to find evidence for state-dependent effects. Conclusions: The current study suggests that taking notes by hand may improve how students encode material, and result in higher quality external storage used by students when studying for quizzes. Teaching Implications: Reinforcing the notion that taking notes by hand may benefit quiz performance for lecture-style information and could improve student performance in class.
Socioeconomic Status and Dehumanization in India: Elaboration of the Stereotype Content Model in a Non-WEIRD Sample

A perceiver’s socioeconomic status (SES) should influence social perceptions toward others. However, there is little evidence for this effect within and beyond Western samples. We hence evaluate the relationship between perceiver SES and dehumanized perception in a society where status is historically defined: India. Across two studies, we hypothesized that perceiver SES would predict dehumanization toward societal outcasts—beggars—and norm violators. Replicating previous work, in Study 1, upper SES perceivers dehumanized beggars more than lower SES perceivers; accounted for by low self-reported contact likelihood. In Study 2, norm violators were perceived as less human but more so by lower rather than upper SES perceivers. This novel finding was partially explained by perceivers viewing female violators as less prototypical, aligned with theorizing in gender research. Our results indicate that SES influences dehumanization via contact likelihood as well as the perceived normativity of a targets’ behavior.
Structural Effect of Phosphoric Esters Having Bulky Substituents on the Extraction of Rare Earth Elements

Phosphoric esters having bis(4-ethylcyclohexyl) (D4ECHPA) and bis(4-cyclohexylcyclohexyl) (D4DCHPA) groups as the alkyl substituents were synthesized in order to investigate their selectivity in the extraction of rare earth elements from acidic nitrate media, together with the apparent molecular weights of the extractants in toluene, the acid dissociation constants and the aqueous distribution coefficients of the extractants. These extractants were found to exist as dimeric species in toluene. The acid dissociation constants of the extractants are nearly the same as that of bis(2-ethylhexyl) hydrogenphosphate (D2EHPA), which is a typical commercial acidic phosphorus extractant. The aqueous distribution coefficients of the extractants become greater in the order D4ECHPA > D2EHPA > D4DCHPA. From the concentration dependencies of the hydrogen ion and extractant on the distribution ratio of rare earth elements, it was concluded that the rare earth elements (M3+) were extracted with D4ECHPA and D4DCHPA (HR) as.
Comment on Dong and Ochsner (2018): “Soil Texture Often Exerts Stronger Influence Than Precipitation on Mesoscale Soil Moisture Patterns”

In their study, Dong and Ochsner (2018, https://doi.org/10.1002/2017WR021692) used an extensive data set of 18 cosmic‐ray neutron rover surveys along a 150 km long transect on unpaved roads to assess the influence of precipitation and soil texture on mesoscale soil moisture patterns. Based on their analysis, they concluded that soil texture, represented by sand content, exerted a stronger influence on mesoscale soil moisture variability than precipitation, represented by the antecedent precipitation index, on 17 of the 18 survey days. However, we found that Dong and Ochsner (2018) made a mistake in their calculation of volumetric soil moisture. After correction, the validity of the original conclusions of Dong and Ochsner (2018) was considerably weakened, as soil texture exerted a stronger influence on soil moisture than precipitation on 12 of the 18 survey days only.
Barriers of students’ adherence to dress code policy in clinical settings: dental students’ viewpoint

Medical universities have called for a professional dress code to preserve the dignity of the medical profession, creating a sense of respect, tranquility, and trust in healthcare recipients and improve patient safety. This study aims to explain the reasons behind poor adherence to the professional dress code by students of the dentistry school. A qualitative study was conducted to explain the viewpoints of dentistry students of Tehran University of Medical Sciences (TUMS). Twenty-three in-depth interviews with dentistry students of different genders, study years, living in different accommodations, and having different tuition payment status were conducted. Conventional content analysis was used to analyze the data. One hundred and twenty initial codes were extracted. They were categorized into common causes of non-adherence to the TUMS Dress Code and specific causes of not following a specific section of the dress code (hygiene, jewelry, and makeup sections). The codes of common causes were categorized into 4 main categories including defects in education, management shortcomings, changes in societal culture, and personal factors. All components of the educational system must be aligned with each other to overcome the barriers against the students’ adherence to professional dress and put forward appropriate interventions at the policymaking, regulatory and educational levels.
Racial Liberalism Resurgent: Connecting Multi-Racial Protests and Electoral Politics Today

Abstract In this paper, we consider the changing nature of today's protest–election connection by looking back to the Blue Wave of the 2018 midterm elections that led to Republicans losing control of the House of Representatives. We ask whether White voters' participation in the Blue Wave of the 2018 elections is related to the multi-racial participation in the #BlackLivesMatter protests of 2020. Could it be that White participation in both is symptomatic of a larger resurgence of racial liberalism that is likely to continue to play a significant role in our politics going forward starting with the 2020 election?
Evaluating the Role of Circulating Dendritic Cells in Methimazole-Treated Pediatric Graves’ Disease Patients

Graves’ disease (GD) is hyperthyroidism associated with organ-specific autoimmune inflammation. GD occurs more frequently in adults than in children; however, pediatric patients are a therapeutic challenge due to cycles of remissions and relapses requiring constant monitoring at every stage of treatment administered. Dendritic cells (DCs) are considered to be a link between innate and adaptive immunity. DCs, as antigen-presenting cells (APCs), are involved in antigen presentation to T lymphocytes, thereby initiating a shift towards effector cells. In accordance, DCs also participate in the modulation of tolerance to specific antigens. To date, the data on DCs’ role in Graves’ pathological processes are scarce. Therefore, here, we evaluated the frequencies and role of circulating DCs in GD pediatric patients treated with methimazole. Flow cytometric analysis was implemented to evaluate three subsets of dendritic cells and their correlation with clinical GD-related parameters. We found significantly higher levels of DC subsets in patients at diagnosis. Furthermore, methimazole treatment seemed to effectively reduce subsets of DCs, which, in addition, were found to differentially correlate with thyroid function. Our study shed new light on DCs’ role in the pediatric GD pathomechanism. Further studies are required for the mechanistic assessment of DCs’ exact role in disease progression and influence on thyroid function.
Sculptorades, Cloodles, and Cameos, Oh My! A Cranium Game for General Psychology

Background: Many instructors use trivia-style review games to encourage self-testing, increase student engagement, and promote collaboration. However, most published examples of review games include trivia questions only, rather than activities that incorporate kinesthetic learning. Objective: We evaluate a review activity modeled after the game Cranium, which includes charades, pictionary, sculpting, and trivia questions. Method: In Pilot Study 1, general psychology students (n = 25) completed a self-report evaluation of Cranium, and we compared performance on exam items practiced during Cranium versus control items. In Pilot Study 2, students (n = 23) were assigned to review for a mock exam via Cranium, a trivia-only version of Cranium, or a practice question review. Results: Students rated Cranium as enjoyable and useful, though not more so than comparison activities, and Cranium elicited similar exam performance to comparison activities. Conclusion: Cranium is similar, not superior, to trivia-only and practice question review activities in terms of student perceptions and exam performance. Teaching Implications: Cranium provides an additional tool for instructors to engage students in team-based review activities in general psychology. Games that incorporate self-testing are likely useful for student engagement and learning, and the specific choice of activity may depend on instructor and student preference.
THE ROLE OF POSITIVE AFFECT MEDIATORS ON PERSON ORGANIZATION FIT AND JOB SATISFACTION

This study was to investigate the role of positive affect on the effect of person-organization fit and employment. This study used a quantitative approach. 135 employees who worked in PT. Perusahaan Listrik Negara (PLN) Tarahan, Bandar Lampung was chosen as the respondent in this study. Measurement of the person-organization fit variable was measured by an instrument developed by Kristof (1996). Job satisfaction was measured using the Michigan organization assessment questionnaire (Bowling & Hammond, 2008). Positive affect was measured using the positive & negative affect schedule (PANAS) developed by Watson et al (1988). Data processing and hypothesis testing used moderating regression analysis. The findings in this investigation are: first, P-O fit had a positive and significant effect on employee job satisfaction, second, positive affect did not moderate the relationship between P-O fit and job satisfaction. This was indicated by the interaction variables that are smaller than the significance value.
Student Readiness Towards E-Learning Adoption in Higher Education: A Conceptual Model Based on Extended Technology Acceptance Model :

This paper main aims are to establish a conceptual model to assess student readiness and acceptance for e-learning. The concept was the extension of the technology acceptance model (TAM). Specifically, the proposed model expands the Technology Adoption Model (TAM) to include the e-learning factor and the readiness factor as external variable. In addition, the participant demographic profile — namely age, gender, and CGPA — is proposed to moderate the influence of these constructs on behavioral intent and the use of technology. A detailed understanding of this model would provide useful insights into the variables that affect the adoption or resistance of the web-based learning system by intended users and provide opportunities for future studies to understand the acceptance of technology. Further, recognizing these factors is helpful for instructors to plan meaningful instructional activities to facilitate the development of student awareness and make learning more efficient and attractive.
Management Strategies and Collaborative Relationships in the Agrifood Supply Chain. Evidence from the Horticultural Sector in Spain

The present article proposes a complete framework for Supply Chain Strategy (SCS) analysis that is adapted to the specific characteristics of the agrifood chain, thereby facilitating management of the former. As a specific case of analysis, the horticultural supply chain, originating in Spain and ending with the European consumer, is analyzed, taking as a reference the marketing companies at origin (mainly social economy companies, i.e.; cooperatives). In addition, a survey of marketing companies is conducted to possibly determine which explicit cooperative growth strategies may include horizontal and vertical collaboration relationships with other members of the chain. The aim is to analyze with whom the cooperative collaborates within the supply chain and the key points of such collaboration. A model analyzing the influence of collaboration on company performance is also considered. The results reveal that, in recent years, aspects related to quality and health have been surpassed and replaced by the concept of sustainability within a framework of collaboration with customers. In any case, it becomes evident that there is a need to expand collaboration within the chain by incorporating the supplier of the supplier, with the aim of making the chain more profitable.