Miracle-dz/UniFAR-FTUs huggingface dataset:
Therapeutic Potential of Green Tea Catechins - A Magical Herb

Today, tea is the most regularly consumed beverage in worldwide. There are mainly four types of tea derived from the leaves of Camellia sinensis plant with different processing methods such as green, white, oolong and black tea. The minimal processing, drying is required to produce green and white tea. White tea (non-oxidized) is manufactured from very young leaves and buds, Green tea (non-oxidized) from mature leaves, Oolong tea (partially oxidized) from partially fermented mature leaves, whereas black tea (oxidized) from fully fermented mature leaves (Wanda, 2017). Nearly 2.5 million tons of tea leaves are produced annually all over the world, among that 20% is green tea (Jayakeerthana, 2016). Green tea has attracted the interest of consumers due to its health benefits against a variety of disorders, ranging from weight loss to cancer. Several reports showed that these non-nutrient bioactive compounds have antioxidant, There is an increasing interest in health benefits of foods and facing a large health problems due to rise in the occurrence of lifestyle disorders such as cancer, heart diseases, diabetes and obesity. Therefore, a lot of interest is generated on the dietary substances, especially, the natural ones that enhance the health of the population. Green tea is a ‘non-fermented’ tea, which is the most popularly consumed beverage in the world. It contains more catechins, than black tea or oolong tea. The health-beneficial effects of green tea are primarily attributed to its polyphenols; around 60–80% of polyphenols in green tea are catechins, which belong to flavan-3-ols, commonly known as catechins, particularly (-)epigallocatechin-3-gallate. This review depicts the recent findings on the medicinal properties of green tea, focusing on the biological properties of the green tea catechins such as antioxidative, anti-hypertensive, antiobesity, anticarcinogenic, cardioprotective, antibacterial activities and anti-inflammatory. Recommendations are also made to increase the bioavailability of the catechins through nanotechnological delivery mechanisms. K e y w o r d s
Some Engineering Properties of Kariya (Hildegardia barteri) Kernel as Influenced by Moisture Content

The knowledge of engineering properties is vital in designing postharvest equipment. In this research work, some physical and thermal properties of kariya (Hildegardia barteri) kernel were studied with respect to moisture content in the range of 8.83 to 27.42 % dry basis (d.b). The surface area, geometric mean diameter, arithmetic mean diameter, bulk density, true density, aspect ratio, sphericity, volume and porosity ranged between 154.09 and 200.29 mm 2 , 7.75 and 8.64 mm, 144.40 and 216.66 mm, 0.65 and 0.72 kg/m 3 , 1.01 and 1.29 kg/m 3 , 0.64 and 0.69 mm 3 , 12.40 and 14.59, 226.94 and 340.23 cm 3 and 40.28 and 98.46, respectively. The static coefficient of friction ranged from 0.42 and 0.53; 0.40 and 0.51; 0.42 and 0.52 for galvanized steel, stainless steel and glass surface respectively. Thermal properties were found to increase from 0.17 to 0.51 kJ/kgK, 1.2 to 2.0 x 10 -7 m 2 /s and 1.43 to 2.73 W/m o C, for specific heat, thermal diffusivity and thermal conductivity respectively. Models were established for all the parameters measured for the kariya kernel as a function of moisture content, with high correlation coefficients. These models can adequately predict the properties within the moisture range examined.
Intra-articular injection in the hind limb joints of dromedary camels (Camelus dromedarius) using anatomical and arthrographic-guided landmarks

Abstract Background and Aim: A healthy joint is an important structure for the proper movement of the camel limb. Intra-articular (IA) injection is frequently used in veterinary practice for diagnostic and therapeutic purposes of joint injuries. Thus, the current study aimed to describe the injection of the hindlimb joints in dromedary camels based on the anatomical and arthrographic-guided landmarks. Materials and Methods: Eighteen orthopedically sound adult camels (mean±standard deviation age: 78±12 months) of both sexes were included in this study. Three camels were euthanized to identify anatomical features in the hindlimb joints and related structures. IA injections were performed in the hindlimbs of 5 camel cadavers to evaluate the optimal IA injection site, which was confirmed by arthrography. The optimized IA injection technique was applied in 10 live camels and confirmed by arthrocentesis and arthrography. For each joint, injection criteria (number of attempts, difficulty of injection, and successful injection) were assessed, scored, and statistically compared to the other joints. Results: The summation of IA injection criteria scores was significantly higher (p<0.05) in the femorotibial, femoropatellar, tibiotarsal, fetlock, pastern, and coffin joints in comparison to the hip joint. Conclusion: Anatomical and arthrographic-guided techniques offer considerable advantages for the characterization of anatomical landmarks and selection of the appropriate IA injection site in the hindlimb in dromedary camels. Furthermore, a reference approach for camels was established that is different from the approach for cattle and horses.
Decision making on the route and duration of antibiotic therapy in acute cellulitis: A systematic review and meta-analyses considering the effectiveness and harms of antibiotic treatment. Running title: Antibiotic treatment decision making for acute cellulitis

http://sro.sussex. ac.uk Cross, Elizabeth L A, Jordan, Harriet, Godfrey, Rebecca, Onakpoya, Igho J, Shears, Annalie, Fidler, Katy, Peto, Timothy E A, Walker, A Sarah and Llewelyn, Martin J (2020) Route and duration of antibiotic therapy in acute cellulitis: a systematic review and meta-analysis of the effectiveness and harms of antibiotic treatment. Journal of Infection, 81 (4). pp. 521-531. ISSN 0163-4453
The Relationship Between Parasocial Relationships and Chronic Ostracism Among Differing Belongingness Needs

Some media consumers are prone to developing parasocial relationships (PSRs)—one-sided attachments viewed as a reciprocal bond—with fictional characters. Study of parasocial relationships has linked this tendency to heightened belongingness needs. However, there is a lack of exploration of how chronic ostracism, a threat to belongingness, relates to PSRs. Thus, the current study examined whether belongingness needs moderated the relationship between forming PSRs and feelings of chronic ostracism. One hundred and eleven participants from a small historically women’s university and the Twitter book community participated in a study which included a survey on tendency to form parasocial relationships, feelings of chronic ostracism, and need to belong. It was found that belongingness needs did not moderate a relationship between parasocial relationships and chronic ostracism. Among those displaying both higher and lower belongingness needs, there was a significant negative correlation between the measure of parasocial relationships and the measure of ostracism. Deviating from the literature, these results suggest that those with feelings of ostracism are not more likely to form PSRs and that PSRs do not compensate for lack of real-life social interaction.
Effects of Fish Waste Effluent on the Growth, Yield and Quality of Cucumis sativus L. Effects of Fish Waste Extract on the Growth, Yield and Quality of Cucumis sa t ivus L. Ainah

This study was conducted to evaluate the potential effects of fish waste extract on the growth, yield and quality of cucumber which is a popular cucurbitaceae fruit vegetable. Different treatments were arranged according with CRD layouts with five replicates for each treatment. All the six (6) treatments viz; control, NPK, 10 ml, 20 ml, 40 ml and 50 ml of fish waste extract were applied to the potting media. The results showed that the application of 20 ml of fish waste extract increased the vine length, number of leaf, chlorophyll content (SPAD), stomatal conductance and leaf TSS content of cucumber compared to other treatments and control. Treatment with 50 mL of fish waste extract produced the highest leaf area. The chlorophyll concentration, carotene content, chlorophyll fluorescence and photosynthetic yield also positively affected with fish waste extracts. It was also found that number of flower, number of fruit, and weight of individual fruit of cucumber also significantly increased by fish waste extracts. It can be concluded that 20 ml fish waste extract was the best treatment for improving the growth, yield and quality of cucumber. Foliar application of fish waste effluent on Cucurbitaceae vegetables is merit to further study.
Digestive diseases of cattle diagnosed at the “Clínica de Bovinos de Garanhuns”-UFRPE: retrospective study and influence of seasonality

Soares G.S. L. , Costa N.A. , Afonso J.A. B. , Souza M.I. , Cajueiro J.F. P., Silva J.C. R. , Ferreira F. & Mendonça C.L. 2021. Digestive diseases of cattle diagnosed at the “Clínica de Bovinos de Garanhuns”-UFRPE: retrospective study and influence of seasonality. Pesquisa Veterinária Brasileira 41:e06800, 2021 Clínica de Bovinos de Garanhuns, Universidade Federal Rural de Pernambuco, Av. Bom Pastor s/n, Boa Vista, Garanhuns, Cx. Postal 152, PE 55292-272, Brazil. E-mail: glieresoares87@gmail.com Diseases of the bovine digestive system make up an important group of diseases, often being responsible for significant economic losses in the livestock sector. The current work aimed to carry out a retrospective study of the diseases of the digestive system in cattle diagnosed at the “Clínica de Bovinos de Garanhuns”, “Universidade Federal Rural de Pernambuco”, from January 1999 to December 2018. In this period, a total of 9,343 cattle were admitted to the CBG-UFRPE, of which 2,238 (24.0%) were diagnosed with diseases of the digestive system. In two decades, the total number of cattle admitted annually by the institution almost doubled as well as the number of cases of digestive diseases. The diseases categorized as mechanical/ motor were the most prevalent (33.6%), followed by fermentative (28.4%), gastroenteritis (16.0%), esophageal diseases (9.7%), and diseases of the oral cavity (4.5%). Lesions of the rectum and anus, congenital alterations, and other digestive diseases showed relative frequencies below 4%. Traumatic reticulitis and its sequelae (14.5%) are the most prevalent disorders, followed by simple indigestion (10.1%), esophageal and intestinal obstructive disorders (9.0%), non-specific gastroenteritis (8.6%), displaced abomasum (RDA and LDA) (5.5%), and frothy bloat, ruminal lactic acidosis, and impaction of the forestomach and abomasum, which represented approximately 5% each. In general, these diseases presented a lethality rate of 46.0%, with emphasis on mechanical/motor diseases with a lethality rate of 73.8%. In general, diseases were more prevalent in females, crossbreeds, aged over 24 months, and raised in a semi-intensive system. Diseases of the digestive system increased over the years studied, representing a considerable portion of the diseases that affect cattle raised in this region, which makes up the main milk basin in the State of Pernambuco, confirming its economic and social impact in the region.
Clinical features of Primary Open Angle Glaucoma at initial presentation: Experience at a tertiary eye care center in Nigeria

Introduction: Glaucoma is a group of optic neuropathies and the leading cause of irreversible blindness worldwide. Primary open angle glaucoma is the commonest type of glaucoma. In affected people, optic nerve fibres are damaged with ensuing loss and raised intraocular pressure in some sufferers. Aim/objectives: To increase knowledge and understanding for improved care of primary open angle glaucoma patients. Method: This was a retrospective study of consecutive 167 hospital patients presenting in Guinness Eye Center Onitsha over a period of February to December 2018 who were diagnosed as having primary open angle glaucoma. Relevant clinical data were studied. Descriptive and correlation statistics were used to ascertain significance of features detected. Results: The patients were 87 (52.1%) males and 80 (47.9%) females. The age range was 17 to 76 years (Mean of 56.4 ± 3.02 years). Mean duration of disease J Opthalmol Res 2021; 4 (3): 244-253 DOI: 10.26502/fjor.2644-00240042 Journal of Opthalmology and Research Volume 4, Issue 3 245 before presentation was 30.4 ± 5.9 months. Visual acuity at presentation was less than 3/60 in 121 (36.2%) eyes. Intra-ocular pressure mean was 26.6 ± 1.6mmHg. The mean of Cup to optic disc ratio is 0.77 ± 0.2. The visual field loss was total or advanced in 69.6%. Using Pearson’s correlation 2-tailed test: cup/disc ratio correlates with duration of presenting symptoms in months at p=0.05, and with intra-ocular pressure at P= 0.01 On non-parametric correlation, using Spearman’s rho 2-tailed test, at p= 0.5, duration of presenting symptoms correlates with age; and at P = 0.01 cup/disc ratio correlates with level of intraocular
Role of Plant Growth Regulators in Gene Expression of SGR Gene Responsible for Stay Green of Wheat Varieties

A field experiment was carried out during winter season of 2019-2020 at AlMhanawyah Research Station Agriculture Research Directorate Babylon Governorate / Iraqi, to study the gene expression of Sgr gene responsible for controlling the duration of staying green in varieties of wheat under effect of plant growth regulator during the two growth stages (vegetative and reproductive) by using quantitative reverse transcription-PCR (RT-qPCR) technique and achieving the highest grain yield for a number of wheat varieties. Randomized complete block design (RCBD) arranged according to split plots used with three replicates. The experiment included twelve wheat varieties (Saberbic, Al-Rasheed, Iraq, Tamoz-3, Al-Adnaniya, Babel, IPA-99, Al-Latifeya, Al-Hashemia, Al-Naeema, Buhooth-10 and Al-Baraka) within main plots and nine treatments of plant growth regulator spraying (spraying of distilled water at tillering and anthesis stages, spraying of Abscisic acid (ABA) at tillering stage, spraying of ABA at anthesis stage, spraying of ABA acid at tillering and anthesis stages, spraying of kinetin at tillering stage, spraying of kinetin at anthesis stage, spraying of kinetin at tillering and anthesis stages, spraying of ABA at tillering stage + kinetin at anthesis stage and spraying of ABA at anthesis stage + spraying of kinetin at tillering stage) within sub plots. The results showed that ABA spraying caused a significant increase in the gene expression of Sgr gene, whereas the spraying of kinetin caused a significant decrease in gene expression. It was observed that the Saberbic variety gave the highest gene expression of Sgr gene (1.44). Al-Rasheed and Iraq varieties showed that the decrease in the vegetative growth period which accounted 65% of lives cycle compared with reproductive stage (35%). Also, It is observed that the spraying of ABA was decreased the number of days of the stage in which it is sprayed or after, while the spraying of kinetin was increased the number of days of the stage in which it is sprayed or after. Besides, the spraying of kinetin at tillering stage revealed a significant increase in the biological yield (11.68-ton ha1), whereas the spraying of ABA at tillering stage + kinetin at anthesis stage had the highest mean of grain yield of (4.63-ton ha-1). Al-Rasheed variety gave the highest mean of grain yield (5.56-ton ha-1).
Authenticity of Commercial Probiotics and Taxonomic Strategies of Bifidobacteria spp

Abstarct The article focuses on two major probiotic-related issues, the first one being the quality control and authenticity of commercially available probiotic products, the second one is various taxonomic strategies to be followed for Bifidobacterial spp. Bifidobacteria, lactic acid bacteria, and a few Enterococcal spp are probiotic microbes. The isolation and identification of probiotic microbes, other than Bifidobacterium, are simple and straightforward. PCR, reverse transcription–PCR, and many more techniques have been developed, and are in extensive use. However, they are irreproducible, laborious, and unreliable for Bifidobacterium. Almost all the problems involve the intrinsic nature of anaerobic or microaerophilic bacteria. Therefore, researchers have concentrated on developing protein-based assays for the simple and rapid identification of members of Bifidobacterium. In this review, I discuss the different methods available for the isolation and identification of this genus. The emphasis is on the F6PPK assay because it is unique to Bifidobacterium spp.
Cloud condensation nuclei activity and droplet formation of primary and secondary organic aerosol mixtures

ABSTRACT Understanding the mixing behavior of anthropogenic primary and biogenic secondary organic aerosol (POA and SOA) is important for characterizing their interactions with water vapor. The following work expands upon previous studies and investigates cloud condensation nuclei (CCN) activity and droplet kinetics of α-pinene SOA formed in an environmental chamber and mixed with diesel or motor oil-diesel fuel POA. The changes in the aerosol mixing are similar to previously published work but this study provides new CCN activity and droplet information. The CCN activity of the unmixed aerosol systems are measured separately; κ = 0.15, 0.11, 0.022 for α-pinene SOA, diesel POA and motor oil-diesel fuel POA, respectively. In the α-pinene SOA + diesel POA mixture, the CCN activity, characterized by κ-hygroscopicity, decreases from κ = 0.15 to 0.06 after an initial injection of the POA but increases to κ = 0.12. The increase in CCN activity occurs after particle collision (coagulation and wall-loss) rates dominate aerosol processes in the chamber. The α-pinene SOA + motor oil-fuel POA does not readily mix and the CCN activity of the complex system increases with time (from κ = 0.022 to 0.10). An empirical equation using unit mass resolution (UMR) AMS data of two different ion fragments reasonably predicts CCN activity of the POA and SOA mixtures. CCN measurement may be a promising tool to gain additional insight into the complex mixtures of organic aerosol and subsequent interactions with water vapor. Copyright © 2018 American Association for Aerosol Research
Plum: Exploration and Prioritization of Model Repair Strategies for Fixing Deep Learning Models †

The accuracy of DL models may not meet the user’s expectations. To tackle this problem, existing work proposed diverse approaches, such as using more optimized training processes and training samples to evolve the model structure or parameters of such faulty DL models. In this paper, we present Plum, a novel hyperheuristic approach to fixing deep learning models. Plum generates a set of DL model candidates by applying low-level repair strategies. It then evaluates and prioritizes repair strategies based on their overall fixing effects exhibited by these model candidates and outputs a fixed DL model by applying the top-ranked repair strategy. We also formulate a novel repair strategy to show the compatibility of Plum in incorporating new repair strategies. The experiment on five DL models showed that Plum achieved improvements in test accuracy by 2.49% and 3.11% on the CIFAR-10 and CIFAR-100 datasets over the baselines and outperformed Apricot and MODE, two previous state-of-the-art deep learning repair techniques.
Mutational Analysis of the Highly Conserved ERY Motif of the Thromboxane A 2 Receptor: Alternative Role in GPCR Signaling

The presence of highly conserved amino acid stretches in G protein-coupled receptors (GPCRs) usually predicts an important role in receptor function. Considerable attention has therefore been focused on the involvement of the highly conserved Glu/Asp –Arg –Tyr (E/DRY) motif at the cytoplasmic end of transmembrane domain 3 in the regulation of GPCR conformational states and/or the mediation of G protein activation. In the present work, we have investigated the role of Glu 129 and Arg 130 in the ERY of thromboxane A 2 receptor α (TP α ) in transfected HEK293 cells. We show that no conservative or non-conservative substitutions of Glu 129 and Arg 130 generated a constitutively active TP α mutant, but a non-conservative mutation of Arg 130 (R130V) yielded a mutant receptor with significantly impaired U46619-induced accumulation of inositol phosphates (IPs). This loss-of-function phenotype seems to be due to the uncoupling of the TP α receptor from G q , as demonstrated by the loss of high-affinity agonist binding, and not to receptor internalization, as shown by localization studies with the R130V-GFP fusion protein. Interestingly, U46619-induced activation of the non-conservative E129V mutant stimulated the production of IPs with a ~10-fold lower EC 50 and a ~2-fold higher E max than in the wild type receptor. Collectively, these data demonstrate that, unlike other GPCRs, mutations of Glu 129 do not induce constitutive activity, whereas Arg 130 is involved in G protein coupling or recognition, and suggest the existence within class A GPCRs of at least two different subclasses that make different uses of the highly conserved E/DRY motif. We have now investigated how Glu and Arg substitutions in the ERY motif of the TP α receptor affect its binding, signaling, and G protein interaction. In addition, we have determined their subcellular localization, using confocal microscopy imaging of the chimeric wild type (WT) and mutant TP α -GFP receptors. Our findings indicate that TP α receptor is resistant to constitutive activation when mutated in its ERY motif, whichplays a fundamental role in G protein recognition. This suggests a function for this motif different from that commonly accepted for other GPCRs in regulating TP α receptor signaling. loss-of-function mutant GPCRs revealed as constitutively desensitized receptors. Biochemistry
Proximate, Phytochemicals, Total Phenolic Content and Antioxidant Activity of Ethanolic Extract of Eucheuma spinosum Seaweed

Several health conditions, including aging, joint inflammations, cancer, and the decrease of organ function related to oxidation, have encouraged the investigation of antioxidants' natural sources. Seaweed is one of the marine commodities that has become the focus of researchers, particularly in correlation to health, such as medicines, functional food, and cosmetics. Euchema spinosum is a red macroalga naturally thrives in Lemukutan coastal, West Kalimantan. This research measured the proximate composition, phytochemical, total phenol content, and determined the antioxidant activity in vitro from the ethanol extract of E. spinosum. Proximate measurements, such as protein was carried out using the micro-Kjeldahl method, fat by the non-polar n-hexane solvent extraction method, and carbohydrate determined using by different calculations. The phytochemicals were identified by reacting to the ethanol extract of E. spinosum. The total phenol was determined spectrophotometrically using gallic acid as a positive control. The antioxidant activity was identified by the DPPH free radical scavenging method. The results showed the proximate was composed of 6.00 % carbohydrates, 0.82% fat, and 1.09 % protein. The ethanol extract of E. spinosum contained phytochemical components of alkaloids, steroids, tannins, saponins, and flavonoids. The total phenol content of 16.47 ± 0.14 % GEA with the ability to inhibit free radicals (IC50) by 90.10 ppm was classified as a strong antioxidant.