Miracle-dz/UniFAR-FTUs huggingface dataset:
Safety of Radiosynovectomy in Hemophilic Synovitis: it is Time to Re-evaluate!

The hemophiliac joint has become an increasing target for radiosynovectomy since the first description by Ahlberg in 1977. Radiosynovectomy with the beta-emitting nuclide has been effective in dramatically reducing the frequency of hemarthroses and resolving chronic synovitis in hemophilic patients. Because the joint-surface erosions secondary to chronic synovitis often occur in early childhood and progress to advanced arthropathy by late adolescence, these patients need therapy in the early stages of life. However, several issues, including radiopharmaceutical choice and the potential side-effects, have been questioned, particularly in younger patients concerning radiation safety. Although the clinicians have been a bit confused about the safety of radiosynovectomy in the pediatric population, recent advances have prompted clinicians to take a renewed interest in the potential side-effects of radiosynovectomy. There is a growing realization that the benefits of properly performed radiosynovectomy should always outweigh any shortor long-term side-effects.
AGE OF ONSET, TYPE OF EXPOSURE, AND ULTIMATE ATTAINMENT OF L2 MORPHO-SYNTACTIC SENSITIVITY

Abstract The present study examined whether early immersive L2 exposure in a foreign language learning context can yield long-term advantages in L2 morpho-syntactic sensitivity. Participants were 40 Korean university students with high English proficiency, who had either attended an English kindergarten or begun learning English in a classroom, and a control group of native English speakers. All participants performed a speeded aural grammaticality judgment task that included the following features: articles, subcategorization, plural -s, third-person -s. Results showed that the English-kindergarten group outperformed the late-classroom group in terms of accuracy for ungrammatical sentences, while the two groups did not differ significantly on grammatical sentences and in reaction time measures. The learners altogether scored higher in plural -s and third-person -s compared to articles. While the native speakers showed near-perfect accuracy and fast reaction times, the highly proficient learners were at near-chance level in detecting morpho-syntactic errors during online L2 aural processing.
Intraseasonal to Interannual Modulation of Diurnal Precipitation Distribution Over Eastern Africa

The modulation of the rainfall diurnal cycle at intraseasonal and interannual time scales is examined using gridded rainfall data over Eastern Africa and the nearby Indian Ocean for the period 1998–2014. Our focus is on the October‐December season which is strongly impacted by both the Madden‐Julian Oscillation (MJO) and the Indian Ocean Dipole Mode (IODM). The effect of the MJO, which is not synchronized across the whole region, is mainly through changes in the amplitude of the diurnal cycle, especially an enhancement of the late afternoon peak in active phases of the MJO. The rainfall phase only shows minor variations between the active and quiescent phases of the MJO, except over the drier regions and the Indian Ocean where the overall diurnal rainfall signal is more uneven. The effect of the positive phase of the IODM (warm western Indian Ocean) on Eastern Africa rainfall is found at any time of the day, but the enhancement is more prominent during the wettest part of the day (generally the afternoon). Substantial changes in the diurnal phase of the rains are found in some land areas away from the coast or from mountain ranges, where the dominant afternoon peak during the negative IODM phase is replaced by a nighttime maximum during the positive phase. Cross‐sections and a cluster analysis of diurnal rainfall patterns over Kenya and southern Somalia suggest that this feature may be associated with the development of longer‐lived rainfall systems propagating inland from the coast during the IODM positive phase.
Effectiveness of Plantar Fascia-Specific Stretching Exercises in Plantar Fasciitis Plantar Fasiitis'te Plantar Fasya Spesifik Germe Egzersiz Tedavisinin Etkinliği

Devrim Ozer, Alper Koksal*, Ali Oner**, Mehmet Akif Kaygusuz Baltalimani Osteopathic Training and Research Hospital, Clinic of Orthopedics and Traumatology, Istanbul, Turkey *Merzifon State Hospital, Clinic of Orthopedics and Traumatology, Amasya, Turkey **Mengucek Gazi Research and Training Hospital, Clinic of Orthopedics and Traumatology, Erzincan, Turkey DOI: 10.4274/haseki.2479 Med Bull Haseki 2015;53:295-8
Multi-Fidelity Multi-Objective Bayesian Optimization: An Output Space Entropy Search Approach

We study the novel problem of blackbox optimization of multiple objectives via multi-fidelity function evaluations that vary in the amount of resources consumed and their accuracy. The overall goal is to appromixate the true Pareto set of solutions by minimizing the resources consumed for function evaluations. For example, in power system design optimization, we need to find designs that trade-off cost, size, efficiency, and thermal tolerance using multi-fidelity simulators for design evaluations. In this paper, we propose a novel approach referred as Multi-Fidelity Output Space Entropy Search for Multi-objective Optimization (MF-OSEMO) to solve this problem. The key idea is to select the sequence of candidate input and fidelity-vector pairs that maximize the information gained about the true Pareto front per unit resource cost. Our experiments on several synthetic and real-world benchmark problems show that MF-OSEMO, with both approximations, significantly improves over the state-of-the-art single-fidelity algorithms for multi-objective optimization.
The prospects of wooden building construction in Malaysia: Current state of affairs

The objective of this study was to evaluate the extent to which the practicing architects in Malaysia were familiar with timber products as a construction material. The materials consumption data was extracted from the Construction Industry Development Board (CIDB) database and was used to conduct a survey among 189 respondent architects. The results indicated that the architects were familiar with common timber products such as plywood, fiberboard, particleboard, and laminated veneer lumber. Correlation analysis of awareness and knowledge against the rate of utilization of these timber products was significant. Furthermore, the most important deterrent factors for the use of timber products in building construction in Malaysia were the high cost, poor durability, restrictive building codes and by-laws, as well as the low fire resistance. More aggressive promotion of timber products as a potential construction material is advisable to be undertaken when the goal is to boost the material’s use in the construction industry. Policy makers may also consider providing financial incentives to increase timber products utilization in building construction in Malaysia.
Growth Performance of Livestock Population in India, Karnataka and North-Eastern Region of Karnataka

Livestock sector plays a prominent role in rural economy for supplementing the income of rural households particularly for landless labourers, small and marginal farmers. The study was conducted to understand the growth and trends of livestock population in India, Karnataka and North-eastern Karnataka. The secondary data pertained to livestock population was collected from various sources. The study revealed that, In India, the growth in total livestock during 1982-2012 indicated that it had grown at an annual growth rate (AGR) of 0.69 per cent. Among livestock, cattle registered an AGR of 0.21 per cent, while buffalo, sheep and goat registered an AGR of 2.31, 1.95 and 1.31 per cent respectively. Whereas in Karnataka, the growth in total livestock was reported at an AGR of 1.13 per cent during 1982-2012. The growth in total livestock of North-Eastern Karnataka (1982-2012) showed with an AGR of 1.68 per cent. Whereas, cattle population growth rate was registered with a negative AGR of -0.21 per cent, but buffalo, sheep and goat registered an AGR of 1.95, 4.35 and 2.17 per cent respectively.
A multicenter phase I study of intravenous administration of reolysin in combination with irinotecan/fluorouracil/leucovorin (FOLFIRI) in patients (pts) with oxaliplatin-refractory/intolerant KRAS-mutant metastatic colorectal cancer (mCRC).

450 Background: Reolysin (reovirus serotype 3) contains a naturally occurring, ubiquitous, non-enveloped human dearing strain reovirus. Reovirus replicates in KRAS-mutant cells resulting in cell lysis. In phase I evaluation, CRC pts received single agent Reolysin with tumor stabilization and CEA response without significant toxicity. Reolysin and irinotecan (IRI) are synergistic in KRAS-mutant preclinical CRC models, providing rationale for this phase I study. Methods: This was a phase I dose escalation study of FOLFIRI + Reolysin. Eligible pts were >18 yrs with histologically confirmed KRAS-mutant mCRC, measurable disease, ECOG PS 0-1, <3 metastatic regimens, and adequate organ function. Standard FOLFIRI was administered with escalating Reolysin doses (range 1x1010 TCID50 to 3x1010 TCID50) in cohorts of 3-6 pts. Reolysin was given IV over 1 hr days 1-5 every 28d (1 cycle). Primary objectives were dose-limiting toxicity (DLT) to determine MTD and pharmacokinetics. Secondary endpoints were antitumor activi.
Literasi Media dan Digital di Indonesia: Sebuah Tinjauan Sistematis

Berbagai penelitian terakhir memperlihatkan bahwa teknologi khususnya internet menciptakan dampak negatif yang begitu besar. Oleh karena itu, peneliti-peneliti komunikasi sepakat bahwa literasi media sangat dibutuhkan untuk mencegah dampak tersebut. Berbagai penelitian literasi media pun dilakukan dalam rangka menemukan model literasi yang tepat. Tujuan penelitian ini adalah untuk mengetahui konsep literasi digital dan metode yang sering digunakan untuk mengukur literasi digital. Penelitian ini merupakan penelitian tinjauan sistematis (systematic review) dengan menggunakan analisis isi sebagai teknik analisis data. Ada beberapa kriteria yang digunakan dalam menyeleksi artikel. Diantaranya adalah artikel dipublikasikan di jurnal terakreditasi di Sinta 2,3, dan 4. Selain itu, penulis juga melakukan pembatasan kata kunci dalam pencarian artikel. Hasil penelitian menunjukkan bahwa definisi konsep literasi digital sangat beragam. Bahkan istilah yang digunakan juga tidak seragam meskipun merujuk pada definisi yang sama. Metode penelitian yang paling banyak digunakan adalah kualitatif deskriptif dengan teknik wawancara, sehingga pemetaan keterampilan literasi digital pun tidak cukup menggambarkan keterampilan informan. Oleh karena itu, penelitian ini merekomendasikan agar penelitian selanjutnya menggunakan metode performance-based research. Penelitian kedepannya juga diharapkan dapat mengelaborasi literasi digital dengan konsep-konsep lainnya.
Positive Body Image and Physical Activity in Pregnant Women

Generally, research has shown pregnant women have a more negative body image pre-pregnancy and early pregnancy compared to mid-to-late pregnancy. Negative body image in this population has been linked to several important pregnancy-related behaviours and poorer mental health that may put the mother’s and baby’s health at risk. In regards to positive body image, there has been a lack of research investigating how positive body image constructs such as body appreciation and embodiment change, and little work has examined how self-objectification changes. In nonpregnant populations, positive body image has been linked to several health behaviours and outcome; thus, it is important to determine if pregnant women experience positive body image during their pregnancy. In addition, participation in physical activity has been linked to improvements in body image via an increase in embodiment and a decrease in selfobjectification in young adult women. Whether this is true for the pregnant population is unknown. The overall purpose of this study was to understand the relationship between positive body image and physical activity in pregnant women. The first purpose was to determine whether body appreciation, embodiment, and self-objectification levels differ across trimester. The second purpose was to determine if physical activity was associated with body appreciation, and if this relationship was mediated by an increase in embodiment and a decrease in selfobjectification. Thirty-one women in the first trimester, 55 in the second trimester, and 75 in the third trimester completed measures of body appreciation, embodiment, self-objectification, and physical activity online. Multivariate analysis of covariance showed all measures differed by trimester. Post-hoc tests showed body appreciation (M = 3.79; SE = 0.08) and embodiment (M = 2.92; SE = 0.05) were higher and self-objectification (M = 3.86; SE = 0.14) lower in third trimester compared to first trimester (M = 3.37; SE = 0.12; M = 2.56; SE = 0.09; M = 4.54; SE = 0.22). Embodiment was also higher in the third trimester (M = 2.92; SE = 0.05) compared to the second trimester (M = 2.67; SE = 0.06). Serial mediation analysis revealed physical activity was associated with body appreciation through an increase in embodiment and a decrease in selfobjectification. The findings from this study indicate positive body image improves across pregnancy and physical activity could be one way to improve positive body image in pregnant women.
Corporate governance factors as predictors of earnings management

Unlike developed markets, emerging markets like India have greater imperfections, have information asymmetry, and are particularly different in terms of accounting transparency, corruption, and corporate governance (CG). Also, concentrated ownership structure of Indian firms is more conducive for opportunistic earnings management (EM). There has been high incidence of financial frauds and EM in India particularly through related party transactions. The CG regulations were revised and enhanced in the year 2014 but increasing cases of financial frauds and CG violations indicate insufficiency of CG laws in the country. Linking CG to financial information in a context where investor protection laws are still evolving is important. The contributions of the present study are: first, it assesses earnings quality (EQ) as a key outcome of EM to confirm, in the Indian context, one of the two opposing perspectives of EM, namely opportunistic and informational. Second, it creates empirical evidence on those firm attributes and CG mechanisms which can predict EQ for investors in India. Third, it provides inputs on the effectiveness of the revised regulations in controlling EM, and finally, it puts forward theoretical rationale for EM and CG practices in India.
Antituberculosis fixed multi-dose combination and single drug therapy in active tuberculosis: What is about drug hypersensitivity reactions?

BACKGROUND: Use of fixed-dose combinations(FDCs) of tablets against tuberculosis(TB)is now being recommended by WHO . However,the composition and dosage recommendations for FDCs differ from those for separate formulations. OBJECTIVE: Compare drug hypersensitivity reactions of anti-TB FDCs as single tablets(ST)in patients with active TB. METHODS: Retrospective study including 560 patients,divided into: Group1(G1 n=250) treated daily with FDCs (rifampicin,isoniazid , ethambutol, pyrazinamid)during 2months and FDCs(rifampicin, isoniazid)during 4months and Control group(G2 n= 290) treated with standardized regimen(2HRZE/4HR). RESULTS: The mean age was 38,1years and active pulmonary TB was predominant in 2groups.Drug hypersensitivity reaction was noted in respectively 13,2%(G1) and 14,8 %(G2). Urticarial reactions was the most adverse effect noted in 28,2%(12,4%vs15,8%). According of the adverse effects there was no statistically difference except hematologic effects:Thrombopenia and leucopenia were stastically higher in patients treated with FDCs (p=0,018). Pyrazinamide was implicated in most cases(55.8%vs 47%, p CONCLUSION: Adverse drug reaction anti-TB drugs whatever form is not an uncommon. Hematologic effects significantly higher in patients treated with FDCs and Significant difference in doses of Isoniazid and Rifampicin can be the reason of these.
Development of Rapid Extra Virgin Olive Oil Quality Assessment Procedures Based on Spectroscopic Techniques

The main objective of this study was to evaluate the feasibility of developing multivariate models to estimate physico-chemical characteristics and antioxidant content of extra virgin olive oil from fluorescence spectra obtained at specific excitation wavelengths. Six replicates of each extra virgin olive oil sample were contained in clear glass bottles. Two replicates were subjected to four weeks of natural indirect light; two bottles for two days; and the third couple were kept it in darkness as a control. For each pair, one bottle was used for spectroscopic measurements and the other was sent to an accredited external laboratory to obtain physico-chemical measurements: acidity, peroxide index, K270, K232, total tocopherols, α-tocopherol, β-tocopherol and γ-tocopherol. Fluorescence emission spectra were acquired at different excitation wavelengths: 326 nm, 350 nm and 365 nm and partial least squares regression (PLSR) models were developed. The highest R2 values were found for excitation at 350 nm, reaching almost 0.9 in most of the parameters.
Neoliberal challenges in context: a case of Hong Kong

The purpose of this paper is to systematically analyze the neoliberal challenges and problems facing public schools in the particular Hong Kong context. ,Based on a systematic and critical analysis on the history and socio-political context of Hong Kong’s school policies and practice as well as the official documents and statistics, this paper examines the impacts of neoliberalism in four main aspects of school education in Hong Kong: school governance, accountability, privatization and government expenditure. ,Convergence, as well as deviation, on neoliberal globalization occurs in the particular Hong Kong context. School bureaucracy has irresistibly expanded. Policymakers have placed increasing emphasis on instrumentally evaluating schools while decentralizing, diversifying and privatizing education. School leadership has become focused solely on succeeding within those imposed performance management and metrics, pulling ahead of school competitions and prioritizing easily quantifiable and measurable tasks. Teachers have faced a potential threat from the loss of autonomy through the market logic and consumerist metrics. The rise of privatized education has further intensified school practices based on competitiveness and performativity. On the other hand, resource cutbacks and financial constraints – problems that are generally inflicted by neoliberal discourse – have rarely occurred in Hong Kong. ,This study is part of concerted efforts in research that adopts the comparative and critical perspectives emerging from different social contexts to consider and flesh out how neoliberalism look across the school systems, how it challenges the systems differently, and how it evokes various responses from within the systems (Apple, 2001). Taken all the efforts together, a finely nuanced understanding of the trails of neoliberalism can help collectively re-discover school education as a social good, and collectively re-imagine and reshape alternatives for the future. ,This paper offers an international and comparative perspective and further nuances to an understanding of how neoliberal policies and ideology are recontextualized in countries across the globe given particularities of different local contexts.
Introducing new implants and imaging techniques for lumbar spinal stenosis

The main objective of this thesis is to compare bony decompression with implantation of interspinous process devices (IPDs) in patients with intermittent neurogenic claudication (INC) caused by lumbar spinal stenosis (LSS). A national survey among Dutch spine surgeons is presented about the usual care of patients with intermittent neurogenic claudication caused by lumbar spinal stenosis. Surgeons’ expectations of different treatment options are presented. The existing evidence on interspinous implant surgery will be systematically reviewed. Results of treatment with IPDs are compared with other (conservative) treatment options. The Foraminal Enlargement Lumbar Interspinosus distraXion (FELIX) trial is described. This double-blind, multicenter, randomized (cost)effectiveness study was designed to answer the question whether treatment with IPDs would be more (cost) effective compared with conventional bony decompression. Short-term results (eight weeks), long-term results (one and two year) and results in different subgroups are described in this thesis. The analysis based on total direct and indirect costs of both procedures (treatment with IPD and bony decompression) are also presented. INC suitable for surgical treatment. The compression on MR images was evaluated and correlated with baseline complaints and long-term clinical outcome.
A comparison of methotrexate with placebo for the maintenance of remission in Crohn's disease

B RIAN G. F EAGAN , M.D., R ICHARD N. F EDORAK , M.D., E. J AN I RVINE , M.D., G ARY W ILD , M.D., P H . D. , L LOYD S UTHERLAND , M.D., A. H ILLARY S TEINHART , M.D., G ORDON R. G REENBERG , M.D., J OHN K OVAL , P H . D. , C INDY J. W ONG , M.S C . , M ARYBETH H OPKINS , R.N. , S TEPHEN B. H ANAUER , M.D., AND J OHN W.D. M C D ONALD , M.D., FOR THE N ORTH A MERICAN C ROHN ’ S S TUDY G ROUP I NVESTIGATORS *
Maintenance Treatment with Azacytidine for Patients with High Risk Myelodysplastic Syndromes or Acute Myeloid Leukaemia in Complete Remission after Intensive Chemotherapy.

Patients with high-risk myelodysplastic syndromes (MDS) or acute myeloid leukaemia (AML) secondary to MDS may reach complete remission (CR) following intensive chemotherapy but the CR-duration is usually very short. Promoter hypermethylation of e.g. tumour suppressor genes is considered to be important in cancerogenesis and a negative risk factor for survival in patients with MDS. We designed a prospective clinical trial to assess the impact of methylation status on the outcome of induction chemotherapy and to evaluate the effect of maintenance treatment with 5-azacytidine (aza) on CR duration. Sixty patients with a median age of 68 years (54–83) with high risk MDS (n=23) or AML (n=37) following MDS were treated with standard doses of daunorubicin and ara-C. Standard prognostic variables, and methylation status of the P15 ink4b (P15) , E-cadherin (CDH) and Hypermethylated in Cancer 1 (HIC) genes were analyzed before treatment. Patients in CR were given low dose aza subcutaneously for 5 days/4 weeks until relapse. The CR rate was 40%; significantly lower in patients with high white blood cell counts (P=0.03) and high CD34 expression on bone marrow cells (P=0.02). While P15 status alone was not associated with CR rate (P=0.25) patients with CDH methylation showed a lower CR rate (P=0.008). Moreover, no patient with hypermethylation of all three genes achieved CR (P=0.03). CDH methylation retained its prognostic value in the multivariate analysis. Hypermethylation was associated with increased CD34 expression but not with blast count or cytogenetic risk group. Median duration of CR was 13 months (2 to +37) and 7/ 23 patients (30%) had a CR duration >20 months. Three of four patients with trisomy 8 had CR >20 months. The overall survival of patients reaching CR was 17 months (6 to +40). Methylation status before treatment did not correlate with CR duration. We demonstrate for the first time a significant impact of methylation status on the outcome of conventional chemotherapy in high-risk MDS and MDS-AML and propose that this variable should be further evaluated in prospective studies. CR duration is promising, with a substantial portion of patients showing durable responses.