Miracle-dz/UniFAR-FTUs huggingface dataset:
Mineral concentrations of grain of bread wheat landraces originated from eastern Anatolia of Turkey

The objectives of this research were to investigate the interrelationships among some mineral concentrations (Fe, Zn, B, Mn, Cu, Mo, K, Mg and Ca) in grain and to evaluate different eastern Anatolian bread landraces with application of the genotype × trait (GT) biplot methodology in visualizing research data. 69 bread wheat genotypes (67 pure lines and 2 cultivars). Fe, Zn, B, Mn, Cu, Mo, K, Mg and Ca contents of bread wheat genotypes changed at the levels between 32.54 and 51.25 mg kg-1, 23.00 and 37.16 mg kg-1, 6.62 and 14.67 mg kg-1, 30.17 and 50.00 mg kg-1, 4.04 and 6.88 mg kg-1, 0.88 and 1.23 mg kg-1, 2.19 and 5.62 g kg-1, 1.04 and 1.72 g kg-1, and 0.37 and 0.55 g kg-1, respectively. Among minerals, B, Zn and Fe concentrations were the most discriminating with the longest vectors from the origin in the biplot. Landraces L10, L48, L2, L55, L17, L14, L36, L16, L53, L22, L32, L53 L65 and Kirik cultivar were the best or the poorest landraces in some or all of the traits since they had the longest distance from the origin of biplot. Among the mineral contents, Fe content was positively correlated with Zn and Mn content. The association of Zn with Mn was positive and significant. B content positive and significant correlated with Mo content. Both Zn and Fe content was negative significant correlated with Ca. The GT biplot method can be used to identify both ideal genotypes and mineral contents in other crops.
Relation of Cord Cortisol Level and Respiratory Distress Syndrome in Preterm

Background: numerous studies have shown that severity of respiratory distress syndrome may affect the endogenous cortisol secretion in preterm infants. Aim of the Work: assess the relationship between Cortisol level in umbilical cord in first and third day after delivery & Respiratory distress syndrome in preterm. Patients and Methods: a case control study that includes 90 preterm infant. Each included infant was submitted to history taking, complete clinical examination and laboratory investigations including complete blood count, arterial blood gases, level of cortisol in day one and day three. Results: in the present work, there was no significant difference between cases and controls as regard age, gender, weight, gestational age, as regards the serum cortisol levels in the studied groups,this study revealed that mean level of serum cortisol in 1stday of life among the three groups showed elevation and showed no significant statistical difference between the three groups (P-value = 0.107) Regarding mean level of serum cortisol in 3rd day of life showed high significant difference between the three groups (P-value = 0.001). group I (without RDS) marked lower than both groups II&III (with RDS), and comparison between group II and III regarding the same value, showed that group III had significant higher level than group II (P-value = 0.001). Conclusion: preterm infants respond to the stress at delivery and cortisol production continues in infants with RDS than those without RDS.
Survival After Implantable Cardioverter-Defibrillator Implantation in the Elderly

Background— The benefit of implantable cardioverter-defibrillators (ICDs) among elderly patients is controversial and may be attenuated by nonarrhythmic death. We examined the impact of age on device-delivered therapies and outcomes after primary or secondary prevention ICD. Methods and Results— In a prospective, inclusive registry of 5399 ICD recipients in Ontario, Canada (February 2007 to September 2010), device-delivered therapies and complications were determined at routine clinic visits. Among primary prevention ICD recipients aged 18 to 49 (n=317), 50 to 59 (n=769), 60 to 69 (n=1336), 70 to 79 (n=1242), and ≥80 (n=275) years, mortality increased with age, as follows: 2.1, 3.0, 5.4, 6.9, and 10.2 deaths per 100 person-years, respectively (P<0.001). Secondary prevention ICD recipients aged 18 to 49 (n=114), 50 to 59 (n=244), 60 to 69 (n=481), 70 to 79 (n=462), and ≥80 (n=159) years also exhibited increasing mortality, as follows: 2.2, 3.8, 6.1, 8.7, and 15.5 deaths per 100 person-years, respectively (P<0.001). However, rates of appropriate shock were similar across age groups: from 6.7 (18–49 years) to 4.2 (≥80 years) per 100 person-years after primary prevention ICDs (P=0.139) and from 11.4 (18–49 years) to 11.9 (≥80 years) per 100 person-years after secondary prevention ICDs (P=0.993). Covariate-adjusted competing risk analysis demonstrated higher risk of death (Ptrend<0.001 for both primary and secondary prevention) but no significant decline in appropriate shocks with older age after primary (P=0.130) or secondary (P=0.810) prevention ICD implantation. Conclusions— Whereas elderly patients exhibited increased mortality after ICD implantation, rates of appropriate device shocks were similar across age groups. Decisions regarding ICD candidacy should not be based on age alone but should consider factors that predispose to mortality despite defibrillator implantation.
Heterologous Immunity and T Cell Stability During Viral Infections: A Dissertation

The immune response to an infection is determined by a number of factors, which also affect the generation of memory T cells afterwards. The immune response can also affect the stability of the pre-existing memory populations. The memory developed after an infection can influence the response to subsequent infections with unrelated pathogens. This heterologous immunity may deviate the course of disease and alter the disease outcome. The generation and stability of memory CD8 T cells and the influence of the history of infections on subsequent heterologous infections are studied in this thesis using different viral infection sequences. Previous studies using mice lacking individual immunoproteasome catalytic subunits showed only modest alterations in the CD8 T cell response to lymphocytic choriomeningitis virus (LCMV). In this study, I found that the CD8 T cell response to LCMV was severely impaired in mice lacking all three catalytic subunits of the immunoproteasome, altering the immunodominance hierarchy of the CD8 T cell response and CD8 T cell memory. Adoptive transfer experiments suggested that both inefficient antigen presentation and altered T cell repertoire contribute to the reduction of the CD8 T cell response in the immunoproteasome knockout mice. Immune responses generated during infections can reduce pre-existing memory T cell populations. Memory CD8 T cells have been shown to be reduced by subsequent heterologous infections. In this study, I re-examined the phenomenon using immune mice infected with LCMV, murine cytomegalovirus (MCMV) and vaccinia virus (VACV) in different infection sequences. I confirmed that memory CD8 T cells were
Higher-order motion processing in the ferret and its development

ii Acknowledgments . V Chapter 1. General introduction . 1 1.1 Visual motion processing across species . 2 1.1.1 Motion processing in primates . 2 1.1.2 Motion processing in mice . 6 1.1.3 Motion processing in carnivores . 7 1.2 Computational models of motion processing . 14 1.2. 1 Models of simple motion processing in lower-order visual areas . 14 1.2. 2 Models of complex motion processing in higher-order visual areas . 17 1.3 Development of the motion pathway . 24 1.3. 1 Development of ferret V1 . 24 1.3. 2 Development of V1 in primates . 28 1.3. 3 Development of higher-order visual cortex in carnivores and primates . 29 1.3. 4 Development of motion processing and perception in humans . 31 1.4 Motivation and summary of chapters . 34
A Comparative Study between Bedside Chest Ultrasound and Traditional Chest Radiography in Critically Ill Patients

Background: Bedside chest ultrasound emerge a sensitive tool with much higher sensitivity than plain chest x-ray. It avoids the cost, risk of transportation to perform the CT chest and that of radiation exposure. Aim of the Study: was to evaluate the sensitivity and the specificity of bedside ultrasound in the detection and the evaluation of chest conditions of critically ill patients in comparison of CT chest as the gold standard tool. Patients and Methods: This prospective study was conducted on a registry of 80 patients with different chest pathology admitted to the Medical-Surgical Intensive Care Unit of Bab Al Shaeria Hospital between March and November 2018. Results: bedside chest ultrasound sensitivity in detection and evaluation of pneumothorax, pleural effusion, and consolidation and Interstitial lung disease in comparison to CT chest showed sensitivity around 93 % with little cost, without risk of radiation exposure and transportation of critically ill patients. Conclusion: Bedside chest ultrasound is a highly sensitive and specific tool in the detection and evaluation of many chest conditions that eliminates the risk of transportation of unstable patients and that of radiation exposure and is easily accessible in resource limited areas.
Effects of pH and temperature on glucose production from tapioca starch using enzymatic hydrolysis : a statistical approach

The aim of this study was to maximize the glucose concentration produced from enzymatic hydrolysis of tapioca starch. The tapioca starch was enzymatically hydrolyzed using α-amylase from Bacillus lichenformis followed by amyloglucosidase action from Aspergillus niger. Effects of liquefaction temperature (X1), saccharification temperature (X2), liquefaction pH (X3) and saccharification pH (X4¬) were evaluated. 24 full factorial design with 1 replicate and 3 centered point was applied to determine the significant parameters affecting the production of glucose concentration. The range of the factors employed were 60 -90˚C (liquefaction temperature), 40-60˚C (saccharification temperature), 5-7 (liquefaction pH) and 4-6 (saccharification pH). The maximum glucose concentration obtained experimentally was 329.10 g/L. The ANOVA shows that the effects of liquefaction temperature and saccharification pH on glucose production were very significant. The saccharification temperature and liquefaction pH, on the other hand did not influence the glucose production. The optimum liquefaction temperature, saccharification temperature, liquefaction pH and saccharification pH suggested by the design of experiment were 90˚C, 60˚C, 7 and 6 respectively. From that optimum condition, the maximum glucose concentration of 331.8 g/L was estimated.
Comparative efficacy of different diluents on liquid preservation of boar semen

The study was carried out to find the effect ofdifferent extenders on preservation of boar semen in liquid condition. Ejaculates (60-15 each from 4 Hampshire boars) were collected twice weekly using dummy sow. The ejaculates having more than 80% initial progressive motility were diluted in 4 different extenders, viz. Belts Ville thawing solution (BTS) Modena, Zomobsa and Guelph/Kiev. The diluted semen was preserved at 18°C up to 96 h. The average sperm motility was 48.08, 43.83,40.56 and 33.41 %, respectively, in BTS, Modena, Zomobsa and Guelph after 96 h of preservation. While live percentage, acrosomal integrity and hypo-osmotic swollen spermatozoa were 53.45, 55.47 and 25.60%, respectively, in BTS; 49.46, 50.06 and 20.56% in Modena; 43.21,44.63 and 19.85% in Zornobsa; and 37.40,40.52 and 19.53% in Guelph extender after 96 h of preservation at 18°C. There was no significant difference observed between BTS and Modena as well as between Zornobsa and Guelph extenders. The results concluded that BTS and Modena are better extenders than Zornobsa and Guelph in terms of motility, viability, acrosomal integrity and hypo-osmotic swollen spermatozoa for liquid preservation of boar semen.
Variabilité génétique des performances de croissance et de ponte dans une lignée de canards de Barbarie sélectionnée à Taiwan : viabilité embryonnaire précoce dans le croisement intergénérique des canards

Les objectifs de ce travail sont d'une part d'analyser la variabilite genetique conjointe de la croissance et de la ponte dans une petite population de canards de barbarie (cairina moschata) selectionnee de facon massale sur le poids vif a l'age de 10 semaines pendant 8 generations a la station de i lan de l'institut de recherches sur l'elevage de taiwan et d'etablir une nouvelle experience de selection sur le poids a 10 semaines. Ils sont d'autre part d'acquerir les connaissances utiles pour ameliorer la fertilite dans le croisement intergenerique entre le canard de barbarie et la cane commune (anas platyrhynchos) mere du mulard, par insemination artificielle, et pour cela d'identifier les incidences de la mortalite precoce des embryons mulards ou des des absences de fecondation. Les parametres genetiques dans la population de base, en utilisant la methode du maximum de vraisemblance restreinte (reml) appliquee a un modele animal, multimodeles et multicaracteres, ont ete estimes pour 6 caracteres de croissance (poids aux ages de 10 et 18 semaines, longueur de la 1eme plume primaire a l'age de 10 semaines) et 5 caracteres de ponte, sur 6572 canetons barbarie controles en croissance et 1515 canes barbarie controlees en ponte. Les effets genetiques additifs directs et maternels, les effets maternels et environnement commun ont ete pris en compte. Les tendances genetiques ont ete calculees. Un nouveau projet avec une lignee selectionnee sur la valeur blup modele animal du poids a 10 semaines et une lignee temoin a ete defini. Une classification basee sur l'observation a l'oeil nu du disque germinal des oeufs avec 9 codes (codes 1 a 9) a ete definie pour identifier, parmi les oeufs mires clairs au mirage au 7eme jour d'incubation, les incidences de la mortalite precoce des embryons mulard ou de l'absence de fecondation. Elle etait basee sur une etude du developpement embryonnaire. Une interpretation biologique a ete recherchee pour les oeufs classes en code 1 a 3 pour preciser l'absence ou la presence de fecondation. Une application a ete faite en observant 2603 oeufs mires clairs au mirage au 7e jour d'incubation (sur 8859 oeuf mis en incuber).
İneklerde Endometritisin Tanısında Klinik Muayene, Endometriyal Sitoloji, Biyopsi Ve Mikrobiyolojik Muayene Bulgularının Karşılaştırılması

Yapilan cali mada ineklerde, endometritis tanisinda endometriyal sitolojinin etkinli i, endometritislerin tanisinda kullanilan di er bazi yontemlerle kiyaslanarak de erlendirildi. Bu amacla 13 akut, 17 kronik endometritisli ve 10 sa likli holstein inek kullanildi. neklerin klinik muayeneleri, uterustan alinan orneklerin mikrobiyolojik ekimleri, uterus yikantilarinin sitolojik muayeneleri ile biyopsi orneklerinin histopatolojik muayeneleri yapildi. Akut olgularda 13 olgunun 8inde vaginal akinti gorulmezken, 5 olguda vaginal akinti gozlendi. Kronik endometritisli ve sa likli ineklerde herhangi bir vaginal akinti tespit edilemedi. Akut, kronik ve sa likli ineklerdeki rektal palpasyon bulgularinin birbirlerine benzerlikler gosterdi i belirlendi. Mikrobiyolojik ekimler sonrasinda akut olgularda 10, kronik olgularda da 8 olguda olmak uzere A. pyogenes, E. coli, Streptococcus spp, Staphylococcus spp, K. Pneumonia ve Maya izole edilirken akut ve kronik toplam 12 olguda ureme olmadi. Histopatolojik muayenelerde akut endometritisli ineklerde lamina epitelyaliste dejenerasyon, deskuamasyon, notrofil lokosit infiltrasyonu, lamina propriada odem, hiperemi, ve notrofil lokosit infiltrasyonu, bez lumenlerinde notrofil lokosit infiltrasyonu, dokulmu bez epitelleri, uterus lumenlerinde ise notrofil lokosit infiltrasyonu belirlendi. Kronik olgularda ise lamina propriada; mononukleer hucre infiltrasyonu, de i ik derecelerde ba doku arti i, subepitelyal bolgede lenfoplazmositer hucre infiltrasyonlari gozlemlendi. Sitolojik muayenelerde akut endometritislerde notrofillerin fazla olduklari tespit edildi. Kronik endometritislerde dominant hucrelerin lenfositler oldu u belirlendi. Epitel/lokosit orani akut endometritislerde ortalama 2.7/1, kronik endometritislerde 2.9/1 bulundu. Bu oran sa likli ineklerde 15 / 1 olarak belirlendi. Sonuc olaraki endometriyal sitolojinin ineklerde endometritis te hisinde saha artlarinda kullanilabilece i kanisina varildi
La trypanosomose cameline à Trypanosoma evansi (Steel 1885), Balbiani 1888, en République islamique de Mauritanie : Résultats d'enquêtes dans le Trarza

Une premiere enquete sur la trypanosomose cameline a Trypanosoma evansi a ete realisee dans la region du Trarza (sud-ouest mauritanien). Deux cent dix-huit frottis sanguins ont ete realises ainsi que 160 analyses serologiques selon un test d'immunofluorescence indirecte. Les jeunes chamelons de moins d'un an semblaient epargnes par l'infection a Trypanosoma evansi, alors que chez les chamelles laitieres, des taux d'infection globaux de 7,3 p. 100 (frottis sanguins) et 24,5 p. 100 (serologie) ont ete trouves. Le mode de conduite du troupeau semble etre un facteur de risque important : ce sont les troupeaux qui frequentent, meme temporairement, les zones boisees de la vallee du fleuve Senegal ou des collections d'eau permanentes (lac de R'kiz) qui presentent les plus forts taux d'infection. Des recommandations aux eleveurs sont proposees, notamment pour les troupeaux de chamelles laitieres du sud du pays
Increased urinary sodium excretion is associated with systolic blood pressure in first degree relatives of hypertensive patients in Ibadan, Southwestern Nigeria

Introduction Understanding the risk factors of hypertension has led to a better understanding of the pathogenesis, prevention and reduction in morbidity of hypertension. It is well known that offsprings of hypertensive parents have an increased risk of developing hypertension. It is therefore necessary to explore the physiological differences between normotensive patients with and without a positive family history of hypertension with respect to their urinary excretion of sodium. Methods This study was carried out at the University College Hospital, Ibadan Nigeria, to determine if normotensive patients with a positive family history of hypertension are different with respect to their urinary excretion of electrolytes and blood pressure. It examined the relationship between 24-hour urinary excretion of sodium, chloride and potassium, urea and creatinine and blood pressure in subjects with and without family history of hypertension. It was a case-control study of sixty-two subjects: normotensive patients’ first degree relatives of primary hypertensive patients and normotensive patients without positive family history. Results The mean (SD) systolic blood pressures for subjects with and without family history of hypertension were significantly different: 120.0(22.25) and 105.0(17.50) respectively, (p=0.001). The mean arterial blood pressures were significantly different: 86.4(10.2) mmHg and 80.1(8.1) mmHg respectively (p=0.010). The mean (SD) 24-hour urinary excretion of sodium for normotensive patients with and without positive family history of hypertension were 180.5 (45.50) mEq/L, and 156.0(36.25) mEq/L respectively. Systolic blood pressure and 24-hour urinary excretion of sodium was also higher in normotensive subjects with a positive family history of hypertension. Conclusion Systolic blood pressure and twenty-four hour urinary excretion of sodium were higher in normotensive subjects with a positive family history of hypertension than in those without a family history of hypertension.
Functional significance of adenosine in carotid body chemosensory activity in control and chronically hypoxic animals

Carotid bodies (CB) are peripheral chemoreceptor organs sensing changes in arterial blood O2, CO2 and pH levels. Hypoxia and acidosis or hypercapnia activates CB chemoreceptor cells, which respond by releasing neurotransmitters in order to increase the action potential frequency in their sensory nerve, the carotid sinus nerve (CSN). CSN activity is integrated in the brainstem to induce a fan of cardiorespiratory reflex responses, aimed at normalising the altered blood gases. Exogenously applied adenosine (Ado) increases CSN chemosensory activity inducing hyperventilation through activation of A2 receptors. The importance of the effects of adenosine in chemoreception was reinforced by data obtained in humans, in which the intravenous infusion of Ado causes hyperventilation and dyspnoea, an effect that has been attributed to the activation of CB because Ado does not cross blood-brain barrier and because the ventilatory effects are higher the closer to the CB it is injected. The present work was performed in order to establish the functional significance of adenosine in chemoreception at the carotid body in control and chronically hypoxic rats. To achieve this objective we investigated: 1) The release of adenosine from a rat carotid body in vitro preparation in response to moderate hypoxia and the specificity of this release. We also investigated the metabolic pathways of adenosine production and release in the organ in normoxia and hypoxia; 2) The modulation of adenosine/ATP release from rat carotid body chemoreceptor cells by nicotinic ACh receptors; 3) The effects of caffeine on peripheral control of breathing and the identity of the adenosine receptors involved in adenosine and caffeine effects on carotid body chemoreceptors; 4) The interactions between dopamine D2 receptors and adenosine A2B receptors that modulate the release of catecholamines (CA) from the rat carotid body; 5) The effect of chronic caffeine intake i.e. the continuous blockage of adenosine receptors thereby simulating a caffeine dependence, on the carotid body function in control and chronically hypoxic rats. The methodologies used in this work included: molecular biology techniques (e.g. immunocytochemistry and western-blot), biochemical techniques (e.g. neurotransmitter quantification by HPLC, bioluminescence and radioisotopic
Is there a role for immunomodulatory drugs in the treatment of mantle cell lymphoma?

Although survival has improved in patients with mantle cell lymphoma (MCL) during the last two decades, thanks to intensified approach upfront and with anti-CD20 targeted treatment, the disease is still regarded as incurable and for the elderly/unfit patient population, there is need for more tolerable and effective treatment options. Immunomodulatory drugs (IMiDs) have demonstrated activity in MCL and could be regarded as attractive components of combinatory regimens for MCL, in light of their broad spectrum of activity and the potency to synergize with monoclonal antibody treatment. This review focus on the role of lenalidomide (L) as single agent in R/R MCL and in combinatory regimens. To date, one can conclude that L is an active agent in MCL, preferably when combined with anti-CD20 antibody, and may have a role as upfront treatment of elderly/unfit patients. Moreover, regimens including lenalidomide in combination with immunochemotherapy and in chemo-free regimens have shown activity, albeit associated with an increased risk of dose-limiting toxicity in untreated patient populations. Randomized trials evaluating the addition of L upfront, and phase I/II trials on L combined with other novel agents such as BTK- and bcl-2 inhibitors are underway and will further bring insight into the role of IMiDs in MCL.
Use of ECMO in Sepsis and Septic Shock

The use of extracorporeal membrane oxygenation (ECMO) has always been controversial in the past. Evidence was mainly build up in neonates and much controversy remained in adults. The main adult indications were mechanical support (e.g., in cardiogenic shock) or respiratory support (e.g., in the field of acute respiratory distress syndrome (ARDS)). Sepsis was historically often considered as a contraindication. As a consequence of sev - eral worldwide flu outbreaks, the use of ECMO in infectious diseases increased. Besides in these viral infections, there was also growing interest for its use in bacterial septicemia, although often as escape therapy. In the recent years, other techniques gained increasing interest like for example, immunoadsorption, implemented in dialysis or ECMO circuits. In this chapter, we resume the available literature on the use of ECMO in septic shock including the use of immunoadsorption techniques.