Miracle-dz/UniFAR-FTUs huggingface dataset:
A Cross-Sectional Study on the Knowledge of Sexually Transmitted Diseases among Young Adults Living in Albaha, Saudi Arabia

Background: Sexually transmitted diseases (STDs) remain one of the most important health challenges in not only developing countries but also developed countries. Discussing STDs in the Saudi society is considered taboo, as social factors and ethics give rise to many obstacles. This study evaluates the knowledge of STDs among young adult students enrolled in Albaha University. Methods: This research is a cross-sectional study involving 1902 young adult students registered at Albaha University. STDs knowledge scores (STDs-KSs) were calculated using a predesigned and validated STDs knowledge questionnaire with 27 items adapted from previously developed questionnaires. Results: The estimated overall mean of STDs-KS was 7.95 ± 4.29. Female participants showed a significantly higher mean of STDs-KS, compared to males (8.51 ± 4.14 vs. 7.32 ± 4.38, p < 0.0001). Participants registered in health sciences programs showed higher STDs-KS, compared to participants from arts and sciences programs (p < 0.0001). Conclusions: Evidence from this study suggests a lack of STDs knowledge among young adults. To promote STDs awareness among this population, more health educational programs should be included in school curricula at the late stages of secondary education.
The Transcription Factor Nfix Requires RhoA-ROCK1 Dependent Phagocytosis to Mediate Macrophage Skewing during Skeletal Muscle Regeneration

Macrophages (MPs) are immune cells which are crucial for tissue repair. In skeletal muscle regeneration, pro-inflammatory cells first infiltrate to promote myogenic cell proliferation, then they switch into an anti-inflammatory phenotype to sustain myogenic cells differentiation and myofiber formation. This phenotypical switch is induced by dead cell phagocytosis. We previously demonstrated that the transcription factor Nfix, a member of the nuclear factor I (Nfi) family, plays a pivotal role during muscle development, regeneration and in the progression of muscular dystrophies. Here, we show that Nfix is mainly expressed by anti-inflammatory macrophages. Upon acute injury, mice deleted for Nfix in myeloid line displayed a significant defect in the process of muscle regeneration. Indeed, Nfix is involved in the macrophage phenotypical switch and macrophages lacking Nfix failed to adopt an anti-inflammatory phenotype and interact with myogenic cells. Moreover, we demonstrated that phagocytosis induced by the inhibition of the RhoA-ROCK1 pathway leads to Nfix expression and, consequently, to acquisition of the anti-inflammatory phenotype. Our study identified Nfix as a link between RhoA-ROCK1-dependent phagocytosis and the MP phenotypical switch, thus establishing a new role for Nfix in macrophage biology for the resolution of inflammation and tissue repair.
Smart-Sensor for the Automatic Detection of Electromechanical Faults in Induction Motors Based on the Transient Stray Flux Analysis

Induction motors are essential and widely used components in many industrial processes. Although these machines are very robust, they are prone to fail. Nowadays, it is a paramount task to obtain a reliable and accurate diagnosis of the electric motor health, so that a subsequent reduction of the required time and repairing costs can be achieved. The most common approaches to accomplish this task are based on the analysis of currents, which has some well-known drawbacks that may lead to false diagnosis. With the new developments in the technology of the sensors and signal processing field, the possibility of combining the information obtained from the analysis of different magnitudes should be explored, in order to achieve more reliable diagnostic conclusions, before the fault can develop into an irreversible damage. This paper proposes a smart-sensor that explores the weighted analysis of the axial, radial, and combination of both stray fluxes captured by a low-cost, easy setup, non-invasive, and compact triaxial stray flux sensor during the start-up transient through the short time Fourier transform (STFT) and characterizes specific patterns appearing on them using statistical parameters that feed a feature reduction linear discriminant analysis (LDA) and then a feed-forward neural network (FFNN) for classification purposes, opening the possibility of offering an on-site automatic fault diagnosis scheme. The obtained results show that the proposed smart-sensor is efficient for monitoring and diagnosing early induction motor electromechanical faults. This is validated with a laboratory induction motor test bench for individual and combined broken rotor bars and misalignment faults.
Surface-Modified Industrial Acrylonitrile Butadiene Styrene 3D Scaffold Fabrication by Gold Nanoparticle for Drug Screening

Biocompatibility is very important for cell growth using 3D printers, but biocompatibility materials are very expensive. In this study, we investigated the possibility of cell culture by the surface modification of relatively low-cost industrial materials and an efficient three-dimensional (3D) scaffold made with an industrial ABS filament for cell proliferation, spheroid formation, and drug screening applications. We evaluated the adequate structure among two-layer square shape 3D scaffolds printed by fused deposition modeling with variable infill densities (10–50%). Based on the effects of these scaffolds on cell proliferation and spheroid formation, we conducted experiments using the industrial ABS 3D scaffold (IA3D) with 40% of infill density, which presented an external dimension of (XYZ) 7650 µm × 7647 µm × 210 µm, 29.8% porosity, and 225 homogenous micropores (251.6 µm × 245.9 µm × 210 µm). In the IA3D, spheroids of cancer HepG2 cells and keratinocytes HaCaT cells appeared after 2 and 3 days of culture, respectively, whereas no spheroids were formed in 2D culture. A gold nanoparticle-coated industrial ABS 3D scaffold (GIA3D) exhibited enhanced biocompatible properties including increased spheroid formation by HepG2 cells compared to IA3D (1.3-fold) and 2D (38-fold) cultures. Furthermore, the cancer cells exhibited increased resistance to drug treatments in GIA3D, with cell viabilities of 122.9% in industrial GIA3D, 40.2% in IA3D, and 55.2% in 2D cultures when treated with 100 µM of mitoxantrone. Our results show that the newly engineered IA3D is an innovative 3D scaffold with upgraded properties for cell proliferation, spheroid formation, and drug-screening applications.
Exploring patients' and clinicians' experiences of video consultations in primary care: a systematic scoping review

Background Video consultation (VC) is an emerging consultation mode in general practice. The challenges and benefits of implementing it are not necessarily realised until it is in use, and being experienced by patients and clinicians. To date, there has been no review of the evidence about how patients and clinicians experience VC in general practice. Aim The study aimed to explore both patients' and clinicians' experiences of VCs in primary care. Design & setting A systematic scoping review was carried out of empirical studies. Method All major databases were searched for empirical studies of any design, published from 1 January 2010 to 11 October 2018 in the English language. Studies were included where synchronous VCs occurred between a patient and a clinician in a primary care setting. Outcomes of interest related to experience of use. The quality of included studies were assessed. Findings were analysed using narrative synthesis. Results Seven studies were included in the review. Patients reported being satisfied with VC, describing reduced waiting times and travel costs as a benefit. For patients and clinicians, VC was not deemed appropriate for all presentations and all situations, and a face-to-face consultation was seen as preferable where this was possible. Conclusion The findings of this scoping review show that primary care patients and clinicians report both positive and negative experiences when using VCs, and these experiences are, to a certain extent, context dependent. VC is potentially more convenient for patients, but is not considered superior to a face-to-face consultation. Accounts of experience are useful in the planning and implementation of any VC service.
Chitosan Oligosaccharides Attenuate Amyloid Formation of hIAPP and Protect Pancreatic β-Cells from Cytotoxicity

The deposition of aggregated human islet amyloid polypeptide (hIAPP) in the pancreas, that has been associated with β-cell dysfunction, is one of the common pathological features of patients with type 2 diabetes (T2D). Therefore, hIAPP aggregation inhibitors hold a promising therapeutic schedule for T2D. Chitosan oligosaccharides (COS) have been reported to exhibit a potential antidiabetic effect, but the function of COS on hIAPP amyloid formation remains elusive. Here, we show that COS inhibited the aggregation of hIAPP and disassembled preformed hIAPP fibrils in a dose-dependent manner by thioflavin T fluorescence assay, circular dichroism spectroscopy, and transmission electron microscope. Furthermore, COS protected mouse β-cells from cytotoxicity of amyloidogenic hIAPP, as well as apoptosis and cycle arrest. There was no direct binding of COS and hIAPP, as revealed by surface plasmon resonance analysis. In addition, both chitin-oligosaccharide and the acetylated monosaccharide of COS and glucosamine had no inhibition effect on hIAPP amyloid formation. It is presumed that, mechanistically, COS regulate hIAPP amyloid formation relating to the positive charge and degree of polymerization. These findings highlight the potential role of COS as inhibitors of hIAPP amyloid formation and provide a new insight into the mechanism of COS against diabetes.
Efficacy and Safety of First-Line Everolimus Therapy Alone or in Combination with Octreotide in Gastroenteropancreatic Neuroendocrine Tumors. A Hellenic Cooperative Oncology Group (HeCOG) Study

The purpose of this study was to explore the efficacy and safety of everolimus administered as a first-line treatment in newly diagnosed patients with metastatic or inoperable gastroenteropancreatic neuroendocrine tumors (GEP NETs). This phase II, multicenter, single-arm study included patients with well-differentiated GEP NETs and a Ki67 < 20%. Everolimus, at 10 mg/day, was administered until disease progression; 18 patients (72%) concomitantly received octreotide long-acting release (LAR), at 30 mg/month. The primary endpoint was the 15-month progression-free survival (PFS) rate. Twenty-five patients (grade 1: 11 patients, grade 2: 14 patients) were enrolled between August 2012 and October 2015. At a median follow-up of 58.1 months, the median PFS was 14.6 months, while the 15-month PFS rate was 48%; median overall survival had not been reached yet. Normal baseline chromogranin A (<4 nmol/l) confirmed a longer PFS (HR = 0.25, 95% CI 0.08–0.77, p = 0.016). Seven patients (28%) achieved an objective response (one complete response and six partial responses) in a median of 2.6 months. Twenty-three grade 3–4 events were recorded (14 patients). No fatal reactions occurred. This prospective phase II study unravels the notable activity of everolimus as a first-line treatment in patients with GEP NETS and contributes valuable information about the high activity of the combination of everolimus and octreotide LAR in this setting. Clinical trial information: NCT01648465.
Knowledge, Attitudes and Perceptions of Nurses on Personal Protective Equipment: Response to the Middle East Respiratory Syndrome Coronavirus

Purpose:Personal protective equipment (PPE) is critical to protect healthcare workers from pandemic outbreaks. This study was designed to identify nurses’ knowledge, attitude and perceptions on PPE. Methods: Data were collected from 154 nurses working at a tertiary general hospital, where positively diagnosed and suspected patients were accepted and admitted during the Middle East Respiratory Syndrome Coronavirus outbreak in 2015. The PPE tool consists of 20 items for knowledge, and 5 each for attitudes and perceptions.Results:Overall, knowledge for PPEwas higher thanmoderate (76.95/100), but there was a lack for items related to powered air purifying respirator (PAPR). For attitudes, willingness to work in pandemic outbreaks was the most positive (4.04/5.00). Goggles and PAPRwere perceived as themost uncomfortable barriers to work. There was no correlation between knowledge, attitude and perceptions, despite a strong positive correlation between attitude and perceptions. PPE training was identified as a factor to improve knowledge and attitudes on PPE.Conclusion:To respond to pandemic influenza, nurses need to expand their knowledge on PPE up to Level C, and be updated through regular training. Study findings suggest that repetitive studies targeting nurses and other healthcare workers at various hospital settings are necessary.
A Corpus-Based Analysis of Discourse Markers in Curriculum-Based English Textbooks and the English Entrance Exam in Taiwan

The focus on EFL listening has increased in Taiwan. Although previous studies have confirmed the effectiveness of language learners’ knowledge of discourse markers (DMs) in facilitating their listening comprehension, the time spent on DM instruction is relatively short. Hence, the researcher conducted a corpus-based analysis of the DMs used in junior high school English textbooks, listening workbooks, and the English test in the Comprehensive Assessment Program for Junior High School Students (CAP). The study explored the types of exposure to DMs learners received and sought to determine whether textbook and test writers placed adequate emphasis on DMs. The results revealed that the English textbook and CAP English test corpora had higher frequencies of DMs than the listening workbook corpus. The DMs identified in the three corpora were multi-functional and involved using the senses most common to native speakers’ speech. They demonstrated a clear distinction between spoken and written English. However, the DM distributions were mainly limited to the sentence-initial position. Therefore, textbook writers were suggested to focus more on DM distribution and context. Teachers and learners should be aware of the role of DMs in EFL listening comprehension, familiarize themselves with DMs displayed in textbooks, and use authentic listening materials to compensate for textbook deficiencies.
In-vitro, ex-vivo and in-vivo modeling to assess continuous flow cardiac assist physiology and end-organ interactions

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Comparative study of Level of Physical Activity and Mental State for the Elderly

Background: The ageing process is associated to many morphological and functionals alterations among them, the alteration on the mental state has a spotlight, such alterations reflecting directly on the functional autonomy one of elderly person. Objective: The objective of this work was to compare the level of physical exercise and mental on elderly who practices physical activities and who don't practice. Method:The research is transversal kind and comparative and was done with 94 elderly divided in two groups, 48 were on the group of which practice exercise "Grupo de Exercicio" (GE) and 46 from "Grupo Controle" (GC). To collect dates was applied the MEEM, MAC-Q and IPAQ, physical tests to evaluate the functional capacity. The informations were collected and analyzed through the SSP version 20.0. Results: The results showed no significant differences on the mental state on elderly who practices physical activities and who don't practice.On the functional capacity evaluation the elderly from GE group obtained better results than GC group. Conclusion: On this study haven't association between level of physical activities and elderly's mental state.Comparative study of Level of Physical Activity and Mental State for the Elderly
Effectiveness of a New Weight Management Food to Achieve Weight Loss and Maintenance in Client-owned Obese Dogs

Objective- To evaluate weight loss and maintenance parameters in dogs fed a new weight management food (NWMF) and to assess the owner’s perception of the dog’s quality of life. Design- Prospective, uncontrolled/unmasked clinical trial. Animals- One hundred sixty two overweight/obese, otherwise healthy, clientowned dogs. Procedures- Initial evaluation included physical examination, nutritional assessment, ideal body weight (IBW) determination, and weight-loss feeding guidelines development. Monthly follow-up evaluations (for 6 months) encompassed determination of BW, body condition score (BCS), body fat index (BFI), muscle condition score (MCS), and feeding practices. Quality of life assessment by owners included dog’s level of energy, happiness, appetite, begging behavior, flatulence, stool volume, and fecal score.
The influence of body language and expected competency on gaze behaviour while forming an impression of a tennis player

ABSTRACT Cues conveyed by an athlete’s appearance and reputational information provided prior to an encounter have independently been shown to influence the impression perceivers form of others. Underpinning this process, it is not known how a target’s (a) body language, (b) gender or (c) reputation may influence where a perceiver fixates their gaze when an individual comes into view. Participants (N = 106) randomly observed a male or female tennis player appearing on a monitor displaying positive or negative body language having been provided with that player’s recent win/loss record. Eye tracking recorded gaze behaviour in the first 5 s after the player came into view. After segmentation of the player into six areas of interest, MANCOVA at p < . 05 showed a clear preference for perceivers to direct their gaze towards the player’s head region. Body language and player gender influenced distribution of gaze per region of interest, but this was largely unaffected by reputational information. This work indicates that the head region accounts for the largest proportion of gaze when individuals form judgements of opponents in a tennis setting. The balance of where observers look when forming these judgements is influenced by the gender of the player being observed and the body language being displayed.
Respondent-driven sampling: characteristics associated with productive and non-productive recruitment

BACKGROUND: While studying the population of female sex workers (FSWs) in Ukraine using respondent-driven sampling (RDS) methodology, we noticed that seeds could generate recruitment chains different with regards to their length. We presumed that homogeneity among respondents could be associated with prolonging the recruitment chains. Therefore, this study aimed to explore if the tendency of forming long and short chains was related to specific characteristics of FSWs. METHODS: The study employed data from a bio-behavioral survey among FSWs, conducted in 2009, which used RDS method to recruit 975 participants in six Ukrainian cities with four or five initial seeds. Pearson chi-square test was used to evaluate differences in 29 parameters (demonstrating different ways of client search, social interaction, health and behavior of FSWs) between respondents who were included in either five productive (≥80 participants) or 20 non-productive chains. Stratified analysis with multivariable adjusted logistic regression model was carried out to show the association of examined covariates with recruitment productivity. RESULTS: The findings revealed that affiliation to any non-governmental organization (NGO) for FSWs and injection drug users (IDUs) was a significant interaction factor. For those who were not members of the NGOs, while controlling for other covariates in the model, older age, higher level of education, being current or previous drug user, not appealing to state clinics for treatment of sexually transmitted infections (STIs), and involvement in escort services had larger adjusted estimated odds of productive recruitment of FSWs in the study. On the other hand, for members of any NGOs for FSWs/IDUs, street-based way of client search was strongly associated with productive recruitment. CONCLUSIONS: The results of this study suggest that members and non-members of NGOs for FSWs/IDUs have different characteristics that allow them performing productive recruitment. This should be considered while developing a sampling technique for studies of hard-to-reach populations.
Review on Outcome of Pregnancy of Unknown Location and Further Management – A Retrospective Study

Aims: The study aimed to review the outcomes of pregnancy of unknown location (PUL) in EPAU at Yeovil District Hospital and determine the PUL rate and correlate the serial beta hCG with the predicted outcome and review the further management. Methods: A retrospective study over a year period reviewing the cases diagnosed as PUL between 1st November 2014 to 31st October 2015. Those patients between 6 and 15 weeks turning up at EPAC for the 1st visit were included and those patients less than 6 weeks and those for rescans were excluded. Results: The total number of pelvic scans done in EPAC unit at YDH during the study period was 1093. The total number of PUL cases was 96 giving the PUL rate of 9%. Of all the PUL patients the most common outcome was failing pregnancy (53%) and the ectopic pregnancy rate was 9%. PUL patients that ended up with ectopic pregnancy (11%) behave like intrauterine pregnancy (IUP). Among those PUL ended up with IUP, 21 % had suboptimal changes in serial beta hCG. Conclusions: PUL rate in our unit is 9% which is similar to the reported rate in the literature. The predicted outcomes like failing pregnancy, ectopic pregnancy, IUP and persistent PUL are comparable to those reported in the literature. Majority of outcome of PUL is not ectopic. Further management for each outcome of PUL should be based upon good history taking, clinical assessments, haemodynamic stability and patient’s informed choices. *Corresponding author: Wynn Thida, Department of Obstetrics and Gynaecology, Yeovil District Hospital NHS Foundation Trust, Higher Kingston, Yeovil, Somerset, BA21 4AT, UK, Email: maywynn@gmail.com Citation: Thida, W. , et al. Review on Outcome of Pregnancy of Unknown Location and Further Management – A Retrospective Study. (2017) J Gynecol Neonatal Biol 3(1): 14. J Gynecol Neonatal Biol | Volume 3: Issue 1 www.ommegaonline. org