Miracle-dz/UniFAR-FTUs huggingface dataset:
Brazilian organic propolis for prevention and treatment of radiation-related oral acute toxicities in head and neck cancer patients: A double-blind randomized clinical trial

Background: Oral mucositis (OM) is one of the most important acute toxicities from radiotherapy (RT) in head and neck cancer patients and can impair oncologic treatment. Dysphagia, dysgeusia, pain, and oral candidiasis are other common toxicities. Brazilian Organic Propolis (BOP) is a recently described propolis variant and BOP types 4 and 6 have shown important antioxidant, anti-inflammatory, and antifungal properties. Purpose: To investigate the use of BOP as a preventive and/or complementary therapeutic option for radiotherapy-induced oral mucositis, dysphagia, dysgeusia, pain, and oral candidiasis. Additionally, proinflammatory cytokines were assessed to investigate their anti-inflammatory role. Methods: Sixty patients were included in this randomized, double-blind, controlled clinical trial. Patients were randomized to receive either aqueous suspension of a BOP or placebo throughout RT. Also, all patients underwent low-level laser therapy as routine oral care. OM, dysphagia, and dysgeusia were assessed weekly according to WHO and NCI scales. Pain-related to OM was assessed according to a Visual Analog Scale and the presence or absence of oral candidiasis was checked by intraoral examination. Protein levels of TNF-α and IL-1β from oral mucosa were assessed by ELISA. Results: Patients in the propolis group had a lower mean score of OM, dysphagia, dysgeusia, and most patients reported moderate pain. Fewer patients developed oral candidiasis in the propolis group, and the number of episodes was lower among patients that used BOP (p < 0.05). In addition, the BOP group presented significantly lower levels of IL-1β since the beginning of treatment when compared with placebo patients (p < 0.05) and a lower level of TNF-α at the end of treatment (p < 0.001). Conclusion: Topic use of BOP reduced TNF-α and IL-1β levels, oral candidiasis episodes, and seems to be a useful complementary option for the prevention and treatment of the main acute oral toxicities of RT. Clinical Trial Registration: http://www.ensaiosclinicos. gov.br/rg/RBR-9f8c78/, identifier RBR-9f8c78
Erythritol synthesis is elevated in response to oxidative stress and regulated by the non-oxidative pentose phosphate pathway in A549 cells

Background Erythritol is a predictive biomarker of cardiometabolic diseases and is produced from glucose metabolism through the pentose phosphate pathway (PPP). Little is known regarding the regulation of endogenous erythritol synthesis in humans. Objective In the present study, we investigated the stimuli that promote erythritol synthesis in human lung carcinoma cells and characterized potential points of regulation along the PPP. Methods Human A549 lung carcinoma cells were chosen for their known ability to synthesize erythritol. A549 cells were treated with potential substrates for erythritol production, including glucose, fructose, and glycerol. Using siRNA knockdown, we assessed the necessity of enzymes G6PD, TKT, TALDO, and SORD for erythritol synthesis. We also used position-specific 13C-glucose tracers to determine whether the carbons for erythritol synthesis are derived directly from glycolysis or through the oxidative PPP. Finally, we assessed if erythritol synthesis responds to oxidative stress using chemical and genetic models. Results Intracellular erythritol was directly associated with media glucose concentration. In addition, siRNA knockdown of TKT or SORD inhibited erythritol synthesis, whereas siG6PD did not. Both chemically induced oxidative stress and constitutive activation of the antioxidant response transcription factor NRF2 elevated intracellular erythritol. Conclusion Our findings indicate that in A549 cells, erythritol synthesis is proportional to flux through the PPP and is regulated by non-oxidative PPP enzymes.
THE X-RAY CLUSTER NORMALIZATION OF THE MATTER POWER SPECTRUM

The number density of galaxy clusters provides tight statistical constraints on the matter fluctuation power spectrum normalization, traditionally phrased in terms of σ8, the root-mean-square mass fluctuation in spheres with radius 8 h−1 Mpc. We present constraints on σ8 and the total matter density Ωm0 from local cluster counts as a function of X-ray temperature, taking care to incorporate and minimize systematic errors that plagued previous work with this method. In particular, we present new determinations of the cluster luminosity–temperature and mass–temperature relations, including their intrinsic scatter, and a determination of the Jenkins mass function parameters for the same mass definition as the mass–temperature calibration. Marginalizing over the 12 uninteresting parameters associated with this method, we find that the local cluster temperature function implies σ8(Ωm0/0.32)α = 0.86 ± 0.04 with α = 0.30 and 0.41 for Ωm0 ≤ 0.32 and Ωm0 ≥ 0.32, respectively (68% confidence for two parameters). This result agrees with a wide range of recent independent determinations, and we find no evidence of any additional sources of systematic error for the X-ray cluster temperature function determination of the matter power spectrum normalization. The joint WMAP5 + cluster constraints are Ωm0 = 0.30+0.03−0.02 and σ8 = 0.85+0.04−0.02 (68% confidence for two parameters).
Concurrence of osteonecrosis and steroid myopathy secondary to oral steroid therapy in a patient with ABCB1 gene polymorphisms: A case report

Glucocorticoids (GCs) are widely used in various autoimmune diseases. Side effects may occur in patients with long-term or high-dose GC usage. Among them, steroid myopathy and osteonecrosis are two severe forms. We report a patient with pemphigus vulgaris on GC-treatment who developed muscle weakness when a cumulative dose of methylprednisolone reached about 20g (14-80mg/d for 2.5 years). Laboratory tests showed slightly elevated lactate dehydrogenase and hydroxybutyrate dehydrogenase. MRI revealed osteonecrosis in the femoral head, distal femur, and proximal tibia of both legs. The biopsy of the right quadriceps revealed atrophy of type II myofiber without leukocyte infiltration, which was suggestive of steroid myopathy. Genotyping of the patient showed 5G/5G genotype of the PAI-1 gene and CC genotype of the ABCB1 gene (C3435T), suggesting she was sensitive to GCs. The patient’s lesions were considered to be GC-induced adverse events, which were improved with tapering GC. Therefore, it is important to recognize steroid-induced musculoskeletal side effects and genotyping favors personalized medication.
Improving Psychological Wellbeing and Healthcare Outcomes Through Decentralization of Healthcare Expenditures in Pakistan

This article contributes to the limited empirical literature on the impact of decentralization on psychological wellbeing by investigating the hypothesis which signifies that shifts toward more fiscal decentralization in health services would be accompanied by improvements in health outcomes. Formulating a conventional public finance model applied to health care, this hypothesis is tested on a panel data of the Pakistan's provinces during the period 1990 to 2015. The empirical underpinning of the article suggested that the economic reforms of 2001 in Pakistan's healthcare sector, through fiscal decentralization, have imposed a substantial and positive influence on the effectiveness of the public policy in improving the healthcare outcomes over the examined period.
Trade-offs in organic nutrient management strategies across mixed vegetable farms in Southwest British Columbia

Balancing economic and environmental objectives can present trade-offs for organic farmers maximizing crop yields while maintaining core principles of ecology and health. A primary challenge for achieving this balance is nitrogen (N) and phosphorus (P) management. Meeting crop N requirements with compost can build soil carbon (C) and soil health but often over-applies P and increases soil P and associated environmental risks. Alternatively, high-N organic fertilizers can provide N without surplus P but can be expensive and lack C inputs that composts supply. We evaluated these potential trade-offs in 2-year field trials on 20 mixed vegetable farms across three regions of Southwest British Columbia, Canada, capturing a range of climatic-edaphic conditions and organic amendments. Three nutrient management strategies were evaluated: High Compost: compost applied to meet crop N removal, Low Compost + N: compost applied to meet crop P removal plus an organic fertilizer to meet crop N removal, and Typical: varying combinations of composts and/or organic fertilizers (“typical” nutrient application on the farm). Nutrient strategies were evaluated in terms of yield, input costs, and soil properties [permanganate oxidizable C (labile C responsive to soil management), and post-season available N and P]. Soil P was 21% higher with High Compost than Low Compost + N. In one region characterized by inexpensive but nutrient-rich composts and soils high in P, input costs were lowest with Typical, but in the second year, High Compost outperformed Typical in crop yield. Principal component analysis showed a divergence in post-season NO3- between nutrient strategies in relation to compost and soil properties: High Compost using high-N composts increased post-season NO3- (0–30 cm), whereas relative yields in High Compost tended to be higher on farms with lower soil C and lower C:N composts, while yields with Typical were higher under opposite conditions but associated with higher post-season NO3-. Combining input types (e.g., Low Compost + N) can meet environmental objectives in reducing surplus soil P without short-term yield or cost trade-offs compared to High Compost. However, maintaining soil C needs to be investigated to achieve effective ecological nutrient management in organic vegetable production with improved nutrient balances.
The oral-gut axis: Salivary and fecal microbiome dysbiosis in patients with inflammatory bowel disease

Inflammatory bowel disease (IBD) is a group of chronic inflammatory disorders that fall into two main categories: Crohn’s disease (CD) and ulcerative colitis (UC). The gastrointestinal tract extends from the mouth to the anus and harbors diverse bacterial communities. Several sequencing-based studies have identified an intestinal enrichment of oral-associated bacteria and demonstrated their ability to induce intestinal inflammation in mice, suggesting that intestinal pathobionts originate from the oral cavity, particularly members of the genus Streptococcus. This study aimed to investigate the composition of the salivary and fecal microbiome of IBD patients (n = 14) compared to healthy controls (n = 12) and to determine the abundance of common bacterial taxa in both niches. Metagenomic DNA was extracted from saliva and fecal samples, and the 16S rRNA gene was targeted for sequencing. Our results revealed that the overall microbial composition of saliva was significantly altered in the IBD patients compared to the control subjects (p = 0.038). At the genus level, Veillonella and Prevotella were highly abundant in IBD (median: 25.4% and 22.2%, respectively) compared to the control group (17.9% and 13.4%, respectively). In contrast, Neisseria, Streptococcus, Haemophilus, and Fusobacterium were associated with a healthy gut state. Regarding the fecal microbiome, the IBD group had a significantly higher abundance of Clostridium sensu stricto 1 and Escherichia-Shigella (both comprising pathogenic bacteria) compared with the control group. Members of both bacterial groups have previously been shown to positively correlate with intestinal inflammation and high expression of pro-inflammatory cytokines that disrupt intestinal barrier integrity. In addition, we demonstrate that the increased abundance of Clostridium sensu stricto 1 and Escherichia-Shigella has also been associated with significant upregulation of certain metabolic pathways in the feces of the IBD group, including bacterial invasion of epithelial cells. Streptococcus was the only common genus detected in both the salivary and fecal microbiome and represented the oral-gut axis in our study. Using culture-based methods, we isolated 57 and 91 Streptococcus strains from saliva as well as 40 and 31 strains from fecal samples of the controls and IBD patients, respectively. The phylogenetic tree of streptococci based on sodA sequences revealed several patient-specific clusters comprising salivary and fecal streptococcal isolates from the same patient and belonging to the same species, suggesting that the oral cavity is an endogenous reservoir for intestinal strains.
Hydrogen sulfide activatable metal-organic frameworks for Fluorescence Imaging-Guided Photodynamic Therapy of colorectal cancer

Photodynamic therapy (PDT) is a promising alternative and palliative therapeutic strategy for colorectal cancer (CRC). A novel photosensitizer with higher selectivity for CRC and fewer side effects is vital for clinical application. Given that the overexpression of hydrogen sulfide (H2S) in CRC, it is expected to provide a selective stimulus for activatable photosensitizers that in respond to the specific microenvironment. Herein, we report a novel development of metal-organic frameworks (MOFs) composed of meso-Tetra (4-carboxyphenyl) porphine (TCPP) and ferric ion (Fe3+) through a facile one-pot process. Experiments both in vitro and in vivo reveal that the MOF is capable of depredating in response to the high content of H2S in tumor microenvironment of CRC. Accompanying with the degradation and release of TCPP, the fluorescence and photosensitivity effect is switched from “off” to “on”, enabling the MOF to serve as a H2S activatable nano-photosensitizer for real-time fluorescence imaging-guided and targeted PDT of CRC.
Review on data-centric brain-inspired computing paradigms exploiting emerging memory devices

Biologically-inspired neuromorphic computing paradigms are computational platforms that imitate synaptic and neuronal activities in the human brain to process big data flows in an efficient and cognitive manner. In the past decades, neuromorphic computing has been widely investigated in various application fields such as language translation, image recognition, modeling of phase, and speech recognition, especially in neural networks (NNs) by utilizing emerging nanotechnologies; due to their inherent miniaturization with low power cost, they can alleviate the technical barriers of neuromorphic computing by exploiting traditional silicon technology in practical applications. In this work, we review recent advances in the development of brain-inspired computing (BIC) systems with respect to the perspective of a system designer, from the device technology level and circuit level up to the architecture and system levels. In particular, we sort out the NN architecture determined by the data structures centered on big data flows in application scenarios. Finally, the interactions between the system level with the architecture level and circuit/device level are discussed. Consequently, this review can serve the future development and opportunities of the BIC system design.
Neutrophil-to-lymphocyte ratio predicts parenchymal hematoma after mechanical thrombectomy in basilar artery occlusion

Background parenchymal hematoma (PH) is a severe complication of endovascular treatment (EVT) for acute basilar artery occlusion (ABAO). This study aimed to evaluate the incidence and predictors of PH after EVT for ABAO. Methods Using data from the Endovascular Treatment for Acute Basilar Artery Occlusion Study, we enrolled patients treated with mechanical thrombectomy from the BASILAR registry. PH was assessed in accordance with the Heidelberg Bleeding Classification. Logistic regression was used to identify predictors of PH. Results A total of 639 patients were included. Forty-eight patients (7.5%) were diagnosed with PH within 48 h of EVT. Ninety-day mortality was higher in patients with PH compared with those without (81.3 vs. 42.8%, P < 0.001). Favorable neurological outcomes (modified Rankin scale score, 0–3) rates was lower in patients with PH compared with those without (6.3 vs. 34.5%, P < 0.001). With a multivariate analysis, hypertension [odds ratio (OR) = 2.30, 95% confidence interval (CI) 1.04–5.08], pre-treatment National Institutes of Health Stroke Score (NIHSS, >25; OR = 3.04, 95% CI 1.43–6.45), and Neutrophil-to-lymphocyte ratio (NLR, >10; OR = 1.88, 95% CI 1.02–3.48) were associated with PH after EVT. Conclusions PH occurred at a rate of 7.5% after EVT in patients with ABAO. Hypertension, higher baseline NIHSS, and higher NLR value increase the risk of PH after EVT for ABAO.
Entrepreneurial mindfulness and organizational resilience of Chinese SMEs during the COVID-19 pandemic: The role of entrepreneurial resilience

Organizational resilience is vital to the survival and thriving of enterprises, especially during the COVID-19 pandemic. Although there has been an increasing interest in organizational resilience, the effects from the entrepreneur perspective receive scant attention. Based on upper echelons theory (UET) and personality psychology, we propose a model in which entrepreneurial mindfulness and entrepreneurial resilience could influence organizational resilience of SMEs. We empirically analyzed a sample of 180 entrepreneurs managing small- and medium-sized enterprises (SMEs) in China during the COVID-19 pandemic, using SmartPLS software. The research findings indicated that entrepreneurial mindfulness is positively associated with organizational resilience and such relationship is partially mediated by entrepreneurial resilience. These findings convey important theoretical implications in this field of research as well as practical implications for SMEs in China or other countries with similar nature.
Coronavirus pandemic impact on bank performance

This study examines the effects of the coronavirus (COVID-19) epidemic on the performance of the banking sector. Our sample consists of 1,575 banks in 85 countries from 2020Q1 to 2021Q4. The findings demonstrate that the COVID-19 outbreak has significantly decreased bank performance. Moreover, the adverse impact of COVID-19 on the bank’s performance depends on the bank’s and country-specific aspects. The adverse effect of the COVID-19 outbreak on bank performance is higher in smaller, undercapitalized, and less diversified banks. At the same time, a better institutional environment and financial development have significantly increased the strength and resilience of banks. The results are quite robust to using the alternative bank performance measures and estimation techniques. These findings provide practical implications for regulators and policymakers in the face of unprecedented uncertainty caused by COVID-19 epidemics.
1 Flavonols contrary affect the interconnected glucosinolate and camalexin biosynthesis 1 pathway in Arabidopsis thaliana 2

exogenous flavonol supplementation in A. thaliana seedlings, for the first-time revealed the inverse regulation of interconnected specialized metabolite pathways by flavonol aglycones, and -glycosides. Flavonols negatively regulate camalexin biosynthesis, while promoting the accumulation of aliphatic glucosinolates. Our study adds new insights into the expanding plethora of biological activity of flavonols in plants and will help to uncover the molecular mechanisms by which flavonols interfere with the relevant signal chains and their molecular targets. Abstract Flavonols are structurally and functionally diverse molecules playing roles in plant biotic and abiotic stress tolerance, auxin transport inhibition, pollen development, etc. Despite their ubiquitous occurrence in land plants and multifunctionality, the effect of perturbation of 37 flavonol biosynthesis over global gene expression and pathways other than flavonoid 38 biosynthesis has not been studied in detail. To understand the signaling role of different 39 flavonol metabolites, herein, we used the flavonol deficient Arabidopsis thaliana loss-of- 40 function mutant flavonol synthase1 (fls1-3) as object of study. Comparative transcriptome 41 and metabolic profiling were used to study the effects of genetic flavonol deficiency and 42 exogenous supplementation with flavonol derivatives (kaempferol, quercetin and rutin) on 43 different cellular processes in the seedling. Various flavonol biosynthesis-related regulatory 44 and structural genes were found to be up-regulated in the fls1-3 mutant which could be 45 reversed by exogenous flavonol feeding. Our manifold comparative studies indicated the 46 modulation of various biological processes and metabolic pathways by flavonols. Camalexin 47 biosynthesis was found to be negatively regulated by flavonols. Interestingly, flavonols 48 appeared to promote the accumulation of aliphatic glucosinolate through transcription factor- mediated up-regulation of biosynthesis genes. Overall, this study provides new insights into molecular mechanisms by which flavonols interfere with the relevant signal chains and their 51 molecular targets and adds new knowledge to the expanding plethora of biological activity of flavonols in plants.
A novel truncated LEAP2 palmitoylated at its N-terminal antagonizes effects of ghrelin

Ghrelin is secreted in stomach during fasting and targets the growth hormone secretagogue receptor (GHSR1a) in hypothalamus and brainstem to exert its orexigenic effect. Recently, liver enriched antimicrobial peptide-2 (LEAP2) was identified as an endogenous high affinity GHSR1a antagonist. LEAP2 is a 40 amino acid peptide with two disulfide bridges and GHRS1a affinity in the N-terminal hydrophobic part. In this study, we tested modified truncated N-terminal peptide LEAP2(1-14) along with its myristoylated, palmitoylated and stearoylated analogs to determine their affinity to and activation of GHSR1a and their anorexigenic effects after acute peripheral administration. The lipidized analogs bound GHSR1a with affinity similar to that of natural LEAP2, and lipidization significantly enhanced the affinity of LEAP2(1-14) to GHSR1a. According to the beta-lactamase reporter gene response, natural GHSR1a agonist ghrelin activated the receptor with nanomolar EC 50 . LEAP2(1-14) analogs behaved as inverse agonists of GHSR1a and suppressed internal activity of the receptor with EC 50 values in the 10 -8 M range. LEAP2(1-14) analogs significantly lowered acute food intake in overnight fasted mice, and palmitoylated LEAP2(1-14) was the most potent. In free-fed mice, all LEAP2(1-14) analogs significantly decreased the orexigenic effect of the stable ghrelin analog [Dpr 3 ]Ghrelin. Moreover, palmitoylated LEAP2(1-14) inhibited the growth hormone (GH) release induced by [Dpr 3 ]Ghrelin and exhibited an increased stability in rat plasma compared with LEAP2(1-14). In conclusion, palmitoylated LEAP2(1-14) had the most pronounced affinity for GHSR1a, had an anorexigenic effect, exhibited stability in rat plasma, and attenuated [Dpr 3 ]Ghrelin-induced GH release. Such properties render palmitoylated LEAP2(1-14)