Miracle-dz/UniFAR-FTUs huggingface dataset:
Inferring recent evolutionary changes in speech sounds

In this paper, we investigate evolutionarily recent changes in the distributions of speech sounds in the world's languages. In particular, we explore the impact of language contact in the past two millennia on today's distributions. Based on three extensive databases of phonological inventories, we analyse the discrepancies between the distribution of speech sounds of ancient and reconstructed languages, on the one hand, and those in present-day languages, on the other. Furthermore, we analyse the degree to which the diffusion of speech sounds via language contact played a role in these discrepancies. We find evidence for substantive differences between ancient and present-day distributions, as well as for the important role of language contact in shaping these distributions over time. Moreover, our findings suggest that the distributions of speech sounds across geographic macro-areas were homogenized to an observable extent in recent millennia. Our findings suggest that what we call the Implicit Uniformitarian Hypothesis, at least with respect to the composition of phonological inventories, cannot be held uncritically. Linguists who would like to draw inferences about human language based on present-day cross-linguistic distributions must consider their theories in light of even short-term language evolution. This article is part of the theme issue ‘Reconstructing prehistoric languages’.
Gravettian hand stencils as sign language formatives

Several Upper Palaeolithic archaeological sites from the Gravettian period display hand stencils with missing fingers. On the basis of the stencils that Leroi-Gourhan identified in the cave of Gargas (France) in the late 1960s, we explore the hypothesis that those stencils represent hand signs with deliberate folding of fingers, intentionally projected as a negative figure onto the wall. Through a study of the biomechanics of handshapes, we analyse the articulatory effort required for producing the handshapes under the stencils in the Gargas cave, and show that only handshapes that are articulable in the air can be found among the existing stencils. In other words, handshape configurations that would have required using the cave wall as a support for the fingers are not attested. We argue that the stencils correspond to the type of handshape that one ordinarily finds in sign language phonology. More concretely, we claim that they correspond to signs of an ‘alternate’ or ‘non-primary’ sign language, like those still employed by a number of bimodal (speaking and signing) human groups in hunter–gatherer populations, like the Australian first nations or the Plains Indians. In those groups, signing is used for hunting and for a rich array of ritual purposes, including mourning and traditional story-telling. We discuss further evidence, based on typological generalizations about the phonology of non-primary sign languages and comparative ethnographic work, that points to such a parallelism. This evidence includes the fact that for some of those groups, stencil and petroglyph art has independently been linked to their sign language expressions. This article is part of the theme issue ‘Reconstructing prehistoric languages’.
The history of human land use activities in the Northern Alps since the Neolithic Age. A reconstruction of vegetation and fire history in the Mangfall Mountains (Bavaria, Germany)

Millenia of sustainable, low intensity land use have formed the cultural landscapes of central Europe. Studies from the Central Alps show that mountain pastures also look back onto many thousand years of land use history. In this palynological and pedoanthracological study in the border region between Germany and Austria in the Mangfall Mountains, we aim to close the knowledge gap that exists for the German part of the Northern Alps, where no conclusive evidence for the onset of pastoral activities has been presented so far. Our results reveal strong evidence, that mountain pasture use in this region reaches back to the Iron Age at least. However, the reconstruction of vegetation and fire history indicates human interaction with the environment much earlier, starting in the Neolithic Age, where we found evidence of slash and burn activities and first occurrences of pasture indicator pollen. A rising number of mega charcoal pieces dated to the Bronze Age suggests increased slash and burn activities, possibly linked to the creation of open space for pasturing. Therefore, our results provide profound evidence of human interaction with the mountain environment, beginning in the Neolithic Age and clear evidence of mountain pasture use beginning during the Iron Age at 750 BC. Based on palynology and pedoanthracology it is, however, difficult to clearly differentiate between pasturing, hunting and other human interactions with the environment. Further archaeological studies in this area could add valuable information to our findings and shed more light onto the early history of farming activities in the Northern Alps.
Production and perception of the Pin-Pen merger

Abstract This study presents the first US-wide survey of the pin-pen merger since Labov, Ash & Boberg (2006). Production and perception data were collected from 277 speakers from across the country, with perception-only data from an additional 94 speakers; these data largely replicated previous findings about the social and geographic distribution of the merger. An examination of production and perception data together showed that near merger—in which speakers cannot hear the difference between pin and pen words, yet pronounce them differently—was relatively common, although this phenomenon has received little attention in the literature on the merger. Additionally, an investigation of how merged speakers phonetically realized their merged pin-pen vowel revealed that, in contrast to previous findings, speakers were equally as likely to merge to [ɛ] (tw[ɛ]n for twin) as they were to [i] (h[i]n for hen). However, there was no apparent social or geographic patterning to this phonetic realization.
Inhibitory Control in Individuals with Clinical Levels of Depression and Anxiety Symptoms

Abstract Previous research has shown that individuals suffering from depression and generalized anxiety disorder (GAD) seem to have inhibitory control deficits compared with healthy controls. However, few studies have been conducted in Spanish-speaking countries. Thus, this study aims to analyze the performance on the Stroop Color and Word Test (SCWT) between groups of Colombian participants with clinical levels of depression and GAD symptoms and a nonclinical control group. According to previous research, we expected to find significant differences in inhibitory control among groups. An ex post facto design was implemented. The SCWT was administered to a total sample of 105 individuals (64.8% women, M = 22.94 years, SD = 4.62), including 27 depressed and 15 anxious participants according to their scores on the Personal Health Questionnaire–9 and the Generalized Anxiety Disorder–7, respectively. Bayesian t-tests showed that depressed participants showed the same processing speed but lower scores on inhibitory control than healthy controls, BF = 13.70, δ = 0.50, 95% CI [0.08, 0.94]. Conversely, anxious participants showed deficits in processing speed, SCWT-Word: BF = 16.19, δ = 0.68, 95% CI [0.15, 1.24]; SCWT-Color: BF = 5.98, δ = 0.50, 95% CI [–0.01, 1.04], but not in inhibitory control compared with the nonanxious counterparts. This study provides preliminary evidence concerning the inhibitory control deficits in Colombian depressed individuals and processing speed deficits in those experiencing clinical levels of GAD symptoms.
The Psychological Impact of the COVID-19 Pandemic Affected Decision-Making Processes

Abstract A sample of 641 participants were presented with four decision-making tasks during the first stages of the COVID–19 lockdown in Spain: The dictator game, framing problems, utilitarian/deontological and altruistic/egoistic moral dilemmas. Participants also completed questionnaires on mental health status and experiences related to the COVID–19 pandemic. We used boosted regression trees (an advanced form of regression analysis based on machine learning) to model relationships between responses to the questionnaires and decision-making tasks. Results showed that the psychological impact of the COVID–19 pandemic predicted participants’ responses to the framing problems and utilitarian/deontological and altruistic/egoistic moral dilemmas (but not to the dictator game). More concretely, the more psychological impact participants suffered, the more they were willing to choose the safest response in the framing problems, and the more deontological/altruistic were their responses to moral dilemmas. These results suggest that the psychological impact of the COVID–19 pandemic might prompt automatic processes.
The Isoscattering Point in X-ray Scattering Curves of Globular Solute Particles Measured by the Contrast-Variation Method

The isoscattering point is the specific point at which the X-ray scattering intensity of a solute is independent of the electron density of the solvent and has been observed in the X-ray small-angle scattering curves of globular particles such as micelles and viruses. The condition for the appearance of the isoscattering point has been theoretically derived: if all the solutes are spherical particles of radius R0, the position s* of the isoscattering points are given by 2πs*R0 = tan (2πs*R0), where s = 2 sin θ/λ, λ is the X-ray wavelength and 2θ is the scattering angle. If the solutes have a homogeneous structure, the isoscattering points coincide with the zeros of the intensity curves. The appearance of the isoscattering point with a non-zero intensity value is a direct indication that the solutes have an inhomogeneous structure. The isoscattering point is useful for determination of the radius of a globular solute particle to a good accuracy.
Do Whisky Investors Read the Bible? The Effect of Expert Ratings on the Vintage Single Malt Secondary Market

Abstract This article aims to estimate the effect of expert assessments on the prices for single malt Scotch whiskies on the investment market. Our results obtained using an original dataset combining data from Jim Murray's Whisky Bible and a web trading platform specializing in whisky investment show that the quality rating is not a powerful predictor of investor ask prices, especially when controlling for distillery and bottler reputation. This finding suggests that although the Murray score may embed information of use to unsophisticated investors, its effect on price can be outperformed by a detailed knowledge of the whisky industry. (JEL Classifications: L11, L15, Q13)
Designing multisensory experiences for users with different reading abilities visiting a museum

My work explores how technology can support different forms of reading and sense-making of text and multimedia content before, during, and after a museum visit. This paper will present AIMuseum, our pilot study, and how I plan my research. My main contribution is planned to be on the design, implementation, and evaluation of tools to support reading while catering for different abilities.
Early detection of ovarian carcinoma by proteome profiling based on magnetic bead separation and matrix-assisted laser desorption/ionization time of flight mass spectrometry

In this study, affinity purification with magnetic beads and matrix-assisted laser desorption/ionization time of flight mass spectrometry analysis was used to screen candidate biomarkers of ovarian carcinoma. Mass spectrometry compiled from serum of 30 cases of ovarian carcinomas was compared with that from serum of 10 cases of benign group and13 cases of normal group. Interesting peaks were further sieved from ascites and cystic fluid. Peptides were deduced by searching in http://us.expasy. org/tools/tagident.html and were detected by immunohistochemistry and enzyme-linked immunosorbent assay. Results showed that two peaks of 2881 and 2897Da elevated in the serum, malignant ascite and cyst fluid of cancer groupwhen compared with normal and benign groups were deduced as gastrin-releasing peptide which was higher in the malignant tissues and serum than other two groups. It was concluded that gastrin-releasing peptide in serum might be a potential marker for ovarian carcinoma. Key words: Gastrin-releasing peptide, matrix-assisted laser desorption/ionization time of flight mass spectrometry, magnetic bead, and ovarian carcinoma.
Feasibility of Doppler Ultrasound for Cortical Cerebral Blood Flow Velocity Monitoring During Major Non-cardiac Surgery of Newborns

Background and Aim: Newborns needing major surgical intervention are at risk of brain injury and impaired neurodevelopment later in life. Disturbance of cerebral perfusion might be an underlying factor. This study investigates the feasibility of serial transfontanellar ultrasound measurements of the pial arteries during neonatal surgery, and whether perioperative changes in cerebral perfusion can be observed and related to changes in the perioperative management. Methods: In this prospective, observational feasibility study, neonates with congenital diaphragmatic hernia and esophageal atresia scheduled for surgical treatment within the first 28 days of life were eligible for inclusion. We performed transfontanellar directional power Doppler and pulsed wave Doppler ultrasound during major high-risk non-cardiac neonatal surgery. Pial arteries were of interest for the measurements. Extracted Doppler ultrasound parameters were: peak systolic velocity, end diastolic velocity, the resistivity index and pulsatility index. Results: In 10 out of 14 patients it was possible to perform perioperative measurements; the others failed for logistic and technical reasons. In 6 out of 10 patients, it was feasible to perform serial intraoperative transfontanellar ultrasound measurements with directional power Doppler and pulsed wave Doppler of the same pial artery during neonatal surgery. Median peak systolic velocity was ranging between 5.7 and 7.0 cm s−1 and end diastolic velocity between 1.9 and 3.2 cm s−1. In patients with a vasoactive-inotropic score below 12 the trend of peak systolic velocity and end diastolic velocity corresponded with the mean arterial blood pressure trend. Conclusion: Perioperative transfontanellar ultrasound Doppler measurements of the pial arteries are feasible and provide new longitudinal data about perioperative cortical cerebral blood flow velocity. Trial Registration: https://www.trialregister. nl/trial/6972, identifier: NL6972.
“You Are on the Right Track With the App:” Qualitative Analysis of Mobile Phone Use and User Feedback Regarding Mobile Phone Sexual Risk Assessments for HIV Prevention Research

Background: Accurate self-report of sexual behavior assists in identifying potential HIV exposure in HIV prevention trials. Brief mobile phone assessments, completed daily or after sexual activity, can improve the validity and reliability of self-reported sexual behavior and allow for remote survey completion outside of the clinic setting. We conducted a qualitative study to better understand participants mobile phone use and to explore their perspectives on how to improve an existing mobile application-based sexual risk assessment. Methods: Sexually active, HIV seronegative men (n = 14) and women (n = 15) aged 18–39 years were recruited through an HIV counseling and testing clinic and community outreach in Soweto, South Africa. We conducted qualitative research through four age-stratified focus group discussions (FGDs) and analyzed a brief socio-demographics and mobile phone access questionnaire. All participants completed a sexual risk assessment before the FGD. Using a framework analytic approach, data were coded with Nvivo software. Results: All participants had access to mobile phones and internet, and 27 (93.1%) were able to download applications on their personal phones. Participants preferred mobile risk assessments to be offered in a choice of South African languages, using formal language (as opposed to emojis), with straight-forward wording and limited to five to 10 questions. Most participants found it acceptable to complete the assessment once a week, on a weekday, while a few were willing to complete it after each sexual encounter. It was suggested that a message reminder to complete the assessment should be sent at least daily until it is completed. The majority agreed that a password-protected application with a discreet logo was ideal for privacy, ease of use and flexibility for completion in any setting. A concern with this format, however, was the potential data use requirement. Participants expressed privacy concerns with using SMS, WhatsApp and other social media for risk assessments. Most agreed on an airtime incentive between ZAR5-10 (USD 0.29–0.58) per survey. Participants encouraged researchers to provide feedback to them about their sexual risk. Conclusions: Completion of mobile phone sexual risk assessments can be optimized with minimal incentives by ensuring that questionnaires are simple, brief, infrequent and have trusted privacy measures.
Radiomics of Tumor Heterogeneity in Longitudinal Dynamic Contrast-Enhanced Magnetic Resonance Imaging for Predicting Response to Neoadjuvant Chemotherapy in Breast Cancer

Breast tumor morphological and vascular characteristics can be changed during neoadjuvant chemotherapy (NACT). The early changes in tumor heterogeneity can be quantitatively modeled by longitudinal dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI), which is useful in predicting responses to NACT in breast cancer. In this retrospective analysis, 114 female patients with unilateral unifocal primary breast cancer who received NACT were included in a development (n = 61) dataset and a testing dataset (n = 53). DCE-MRI was performed for each patient before and after treatment (two cycles of NACT) to generate baseline and early follow-up images, respectively. Feature-level changes (delta) of the entire tumor were evaluated by calculating the relative net feature change (deltaRAD) between baseline and follow-up images. The voxel-level change inside the tumor was evaluated, which yielded a Jacobian map by registering the follow-up image to the baseline image. Clinical information and the radiomic features were fused to enhance the predictive performance. The area under the curve (AUC) values were assessed to evaluate the prediction performance. Predictive models using radiomics based on pre- and post-treatment images, Jacobian maps and deltaRAD showed AUC values of 0.568, 0.767, 0.630 and 0.726, respectively. When features from these images were fused, the predictive model generated an AUC value of 0.771. After adding the molecular subtype information in the fused model, the performance was increased to an AUC of 0.809 (sensitivity of 0.826 and specificity of 0.800), which is significantly higher than that of the baseline imaging- and Jacobian map-based predictive models (p = 0.028 and 0.019, respectively). The level of tumor heterogeneity reduction (evaluated by texture feature) is higher in the NACT responders than in the nonresponders. The results suggested that changes in DCE-MRI features that reflect a reduction in tumor heterogeneity following NACT could provide early prediction of breast tumor response. The prediction was improved when the molecular subtype information was combined into the model.
Coping Behaviors and Psychological Disturbances in Youth Affected by the COVID-19 Health Crisis

The COVID-19 pandemic and the quarantine undergone by children in many countries is a stressful situation about which little is known to date. Children and adolescents' behaviors to cope with home confinement may be associated with their emotional welfare. The objectives of this study were: (1) to examine the coping strategies used out by children and adolescents during the COVID-19 health crisis, (2) to analyze the differences in these behaviors in three countries, and (3) to examine the relationship between different coping modalities and adaptation. Participants were 1,480 parents of children aged 3–18 years from three European countries (n Spain = 431, n Italy = 712, and n Portugal = 355). The children's mean age was 9.15 years (SD = 4.27). Parents completed an online survey providing information on symptoms and coping behaviors observed in their children. The most frequent coping strategies were accepting what is happening (58.9%), collaborating with quarantine social activities (e.g., drawings on the windows, supportive applauses) (35.9%), acting as if nothing is happening (35.5%), highlighting the advantages of being at home (35.1%), and not appearing to be worried about what is happening (30.1%). Compared to Italian and Spanish children, Portuguese children used a sense of humor more frequently when their parents talked about the situation. Acting as if nothing was happening, collaborating with social activities, and seeking comfort from others were more likely in Spanish children than in children from the other countries. Compared to Portuguese and Spanish children, Italian children did not seem worried about what was happening. Overall, an emotional-oriented coping style was directly correlated with a greater presence of anxious symptoms, as well as to mood, sleep, behavioral, and cognitive alterations. Task-oriented and avoidance-oriented styles were related to better psychological adaptation (considered a low presence of psychological symptoms). Results also show that unaffected children or children with a lower level of impact were more likely to use strategies based on a positive focus on the situation. This study provides interesting data on the strategies to be promoted by parents to cope with the COVID-19 health crisis in children.
The Impact of Psychological Flexibility on Psychological Well-Being in Adults With Obesity

Obesity is a global health problem that affects both physical and psychological health and well-being. Psychological flexibility is one of the key components related to psychological health. This cross-sectional study aims to investigate the impact of psychological flexibility on psychological well-being in a sample of 220 individuals with obesity. Multivariate analysis was performed to investigate the role of psychological flexibility in explaining psychological well-being, controlling for confounding factors (sex, age, and Body Mass Index). According to the results, psychological flexibility significantly explained psychological well-being. Our study provides additional evidence of the impact of psychological flexibility on psychological well-being. It also provides further support for the importance of integrating psychological flexibility in the psychological interventions for obesity.