Miracle-dz/UniFAR-FTUs huggingface dataset:
Expression of p53, p63, p16, Ki67, Cyclin D, Bcl-2, and CD31 Markers in Actinic Keratosis, In Situ Squamous Cell Carcinoma and Normal Sun-Exposed Skin of Elderly Patients

Background: Age and cumulative exposure to ultraviolet (UV) light are primary contributors to skin cancer development. Regulatory proteins within the cell cycle are essential for the homeostasis of squamous epithelium. Methods: This study assessed the expression of immunohistochemical markers p53, p63, p16, Ki67, Cyclin D, Bcl-2, and CD31 in keratinocyte intraepithelial neoplasia (actinic keratosis and squamous cell carcinoma in situ) compared to normal skin. The objective was to distinguish disease-specific changes from those attributable to ageing and sun exposure in elderly skin. Results. Analysis included 22 actinic keratoses (AK), 7 in situ squamous cell carcinomas (SCC), and 8 normal skin biopsies. The mean age was 78.1 years for the AK/SCC group and 73.8 years for controls, with no significant age difference noted between the groups. The AK/SCC group exhibited a higher occurrence of amorphous masses, higher intensity of p53, lower Bcl-2 expression in the epidermis, higher Bcl-2 expression in the dermis, and higher CD31 expression in the dermis, all of which were statistically significant (p < 0.05). Conclusions: The study identifies distinct differences in the presence of amorphous masses and the expression levels of p53, Bcl-2, and CD31 between sun-exposed skin and in situ cutaneous squamous cell carcinomas, including actinic keratoses.
Effects of land-use changes on the properties of a Nitisol and hydrological and biogeochemical processes in different forest ecosystems at Munesa, south-eastern Ethiopia

Changes in land-use and management can affect soil structure, soil organic carbon (SOC) and other nutrients reserve (such as N, P, S). We analysed organic carbon (OC), total nitrogen (N), and total sulfur (S) in particle-size, aggregate-size and size/density fractions of soil organic matter (SOM) in order to identify the SOM pools most affected by the conversion of a Podocurpus falcatus dominated mixed natural forest into a monoculture Eucalyptus globulus plantation 21 years ago on a reddish brown Nitisol at Munesa, Ethiopia. Bulk soil OC, N, and S concentrations and stocks in soil to 20 cm depth were not significantly changed after the conversion of the natural forest into Eucalyptus plantation, but C/N ratio narrowed significantly. Soil organic C, N and S concentrations, and C/N and C/S ratios in sand and silt separates from the plantation samples were significantly reduced, while clay N and S concentrations had slightly increased. The losses of SOC, N and S in the sand fraction were more pronounced than that in the silt. Aggregate stability and total SOC, N and S concentrations of the aggregates were not significantly different in samples from the Eucalyptus plantation and the natural forest. In the plantation samples, both the free light fraction (LF) and the intra-particulate organic matter (iPOM) C, N and S concentrations associated with the macroaggregates were significantly reduced. Differences in the total amount of the free LF (on the basis of water-stable aggregates proportion) between the two forest types were not apparent, suggesting that SOM quality is more prone to changes in landuse and soil management strategies than the total amount of SOM. The loss of iPOM was
Paradoxical leadership and well-being in turbulent times: a time-lagged study

Introduction Paradoxical leadership has recently been put forward as an approach to leadership that may transcend the inherent contradictions in contemporary organizational and personnel management. Empirical research on its potential role for bolstering employee well-being remains scarce. This study investigated whether paradoxical leadership positively impacts employee well-being, which is operationalized as employees’ job, career and life satisfaction. We rely on sense-making theory to investigate whether such effects are mediated by the mitigation of employee job insecurity perceptions. Methods Convenience sampling techniques were used to collect longitudinal survey data between March and September 2021. In total 287 workers provided usable data. Their ages ranged from 18 to 67 years and were active in various organizations in the Netherlands. Validated measures were used to assess paradoxical leadership, job insecurity, job, career, and life satisfaction. A time-lagged path analysis in Mplus 7.0 was conducted to investigate relationships. Results The results suggest that paradoxical leadership is positively related to job, career and life satisfaction over time. The relationships between paradoxical leadership and job and career satisfaction are partially mediated by the mitigation of perceived job insecurity. Discussion Paradoxical leadership plays a role in fostering worker well-being in these turbulent times. Paradoxical leaders may also help their followers to reframe and better deal with challenging working conditions. Despite the longitudinal data design, an additional data-wave would allow for more stringent testing of the proposed mediation effect, and due to convenience sampling generalization of findings is limited.
The reactivity of carbonates in selected soils from Iran.

This study was conducted to characterize the reactivity of carbonates in the surface horizons of 20 soils (Entisols and Aridisols) from Iran. The samples were analyzed for calcium carbonate equivalent (CCE), active calcium carbonate equivalent (ACCE), non-active calcium carbonate equivalent (N.ACCE), carbonate mineralogy and surface area of carbonates (SSA) by N 2 adsorption. The CCEs ranged from 38 to 228 g/kg of soil, with a mean 105.1g/kg of soil. ACCEs ranged from 13.4 to 99.8 with a mean 37 g/kg of soil. About 34% of CaCO 3 in the soils were able to react with oxalate . There is a considerable scatter of data about the regression line (R 2 = 0.60) between ACCE and CCE. This observation support the idea that calcium carbonate in the soils does not consist of particles with common particle size distributions. This feature of native carbonates is an important property in determining nutrient elements in calcareous soils. The surface area of carbonates was negatively and significantly correlated with CCE (0.52*, n=20), indicating that with increasing CCE content, surface area decreases. X-ray diffraction (XRD) analysis showed that [Mg x Ca 1-x (CO 3)] is the most commonly carbonate in the studied soils. Dolomite was only present in 7 soils.
Effect of water distribution patterns on productivity, fruit quality and water use efficiency of Ziziphus jujuba in arid regions under drip irrigation system

A field experiment was carried out at the Agriculture Experimental Station of King Abdulaziz University located at Hada Alsham to study the effect of water distribution patterns on productivity of Ziziphus jujuba under arid conditions. Three water distribution treatments giving the same amount of water were investigated. The first treatment (T1) contained 8 drippers with a discharge of 4 l/h, the second treatment (T2) 4 drippers with a discharge of 8 l/h and the third one (T3) contained 2 drippers with a discharge of 16 l/h. The drippers were installed to distribute water in a circle with a diameter of 1 m around tree for the two growing seasons of 2009-2010 and 2010-2011. Results revealed that increasing number of drippers with low discharge distributed irrigation water homogenously around trees and covered large area of tree roots. T1 significantly increased branch length, number of branches, collar diameter, soil moisture content and fruit yield and quality. The increase in these parameters was gradually decreased in T2 followed by T3. Increasing number of drippers from 2 to 8 and decreasing dripper discharge from 16 to 4 l/h around tree increased fruit yield by about 78.3% and 69.4% in the first and second seasons, respectively.
THE MYTH OF CHAPARRAL CONVERGENCE

ABSTRACT We examined the concept of vegetation convergence—similar vegetation in similar, but disjunct, environments—using chaparral as it occurs on five continents (chaparral, fynbos, garrigue, kwongan, maquis, mattoral) as a case study. Research on chaparral in the past two decades has generated sufficient information to make a detailed comparison possible. The degree of convergence was found to be superficial; significant differences exist in physiognomy, leaf and life-form spectra, species richness, morphological adaptations to fire, phenology, biomass, and productivity. In addition, ecologically important differences in such abiotic environmental factors as intensity of summer drought, fire frequency and intensity, and soil nutrient status were apparent. Finally, the traditional linkage of chaparral vegetation with mediterranean-type climate does not consistently exist in North America; chaparral ranges beyond the limits of mediterranean climate areas. We need to reexamine not only our ideas about co.
Effects of replacement of cafeteria leftover by concentrate mixture on biological performance and economic return of Washera lambs fed desho grass hay as basal diet

The study was conducted to evaluate the inclusion of cafeteria leftover (CL) on biological performance and economic return of Washera lambs fed desho grass and supplemented with concentrate mix (CM) in Ethiopia. Microbiological analyzes were performed in order to assess the feed safety of CL using standard microbiological guidelines. Twenty-five male Washera lambs with a mean body weight of 21.9±1.01 kg (mean ± SD) were used in randomized complete block design consisted of five replications. The dietary treatments included: 0% CL+100% CM (T1), 25% CL+75% CM (T2), 50% CL+50% CM (T3), 75% CL+25% CM (T4) and 100% CL+0% CM (T5). The data collected includes, chemical composition of diets, nutrient intake, nutrient digestibility, carcass yield and quality. The microbiological quality assessment of the CL indicated that it conformed to satisfactory limits of feed safety and therefore it fit for animal feeding. Sheep under T2 had higher (p<0.001) total dry matter intake (DMI) and organic matter intake (OMI) whereas as compared to other treatment groups, sheep under T1 and T5 had lower (p<.001) total DMI and OMI, respectively. The DM digestibility coefficient was higher (p<0.01) for sheep fed with mixed supplement diet (T2 to T4). The protein digestibility coefficient was higher (p<0.01) for the mixed supplement and lower for solely dried students’ cafeteria leftover (CL). Average daily gain showed higher (p<0.01) for T1 but similar values for treatments (T2 to T4) compared to (T1 and T5). The average empty body weight (EBW) and hot carcass weight (HCW) showed higher (p<0.01) for the dietary treatments (T2 to T4). According to the partial budget analysis, T4 was the most profitable diet, followed by T3, T2, T1, and T5. Based on this, it is possible to conclude that CL could be included in Washera lambs CM rations at a level of 75% without any adverse effect on the performance and carcass characteristics of sheep. Drying and processing of the entire student cafeteria leftover imposed due to sun drying of laxative food leftover such as pasta. As food leftover contains more moisture and is easily spoiled, guidelines for collecting, transporting, drying, and storing raw materials should be developed to ensure the safety of food leftover for animal feed. Thus, further research is required to investigate technological options for properly drying laxative food leftovers such as pasta so that such food leftovers can be used for ruminant animal feed.
Synergistic and antagonistic medicinal activities of essential oil of Monodora myristica

Synergetic and antagonistic medicinal activities of crude and fractionated essential oil from the seed of Monodora myristica were investigated. The crude essential oil was extracted by steam distillation and then subjected to column chromatography; three fractions (N1, N2, and N3) were obtained. To identify the components, gas chromatography and mass spectrometry (GC-MS) investigation was utilized. The phytochemical parameters were determined by standard analytical methods. 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) and 2,2-diphenyl-1-picrylhydrazyl (DPPH) were used to evaluate the antioxidative capacity. and, the anti-diabetic activity was performed using α-amylase and α-glucosidase assay. The Agar diffusion method was used to determine the antibacterial activities. The GC-MS analysis indicated p-cymene (21.12%) as the major component of the crude essential oil. The antioxidant activity using DPPH varied from 614 to 704 µg/mL, while the ABTS activity ranged between 281-342 µg/mL. The α-amylase assay showed fraction N1 with IC50 value of 3.21 µg/mL, while for α-glucosidase assay, fraction N2 with IC50 2.15 µg/mL recorded the least value. The minimum inhibitory concentration values for the crude extract and all the fractions against the strains of bacteria ranged from 6 to 12.5 mg/mL Both crude extract and fractionated essential oil showed antioxidant, anti-diabetic and antibacterial activities.
Designing, Conducting, and Reporting Survey Studies: A Primer for Researchers

Survey studies have become instrumental in contributing to the evidence accumulation in rapidly developing medical disciplines such as medical education, public health, and nursing. The global medical community has seen an upsurge of surveys covering the experience and perceptions of health specialists, patients, and public representatives in the peri-pandemic coronavirus disease 2019 period. Currently, surveys can play a central role in increasing research activities in non-mainstream science countries where limited research funding and other barriers hinder science growth. Planning surveys starts with overviewing related reviews and other publications which may help to design questionnaires with comprehensive coverage of all related points. The validity and reliability of questionnaires rely on input from experts and potential responders who may suggest pertinent revisions to prepare forms with attractive designs, easily understandable questions, and correctly ordered points that appeal to target respondents. Currently available numerous online platforms such as Google Forms and Survey Monkey enable moderating online surveys and collecting responses from a large number of responders. Online surveys benefit from disseminating questionnaires via social media and other online platforms which facilitate the survey internationalization and participation of large groups of responders. Survey reporting can be arranged in line with related recommendations and reporting standards all of which have their strengths and limitations. The current article overviews available recommendations and presents pointers on designing, conducting, and reporting surveys.
Preservation of Chlorophyll Derivatives in Sediments Off Southern California

Sediments from the sea floor off southern California have been examined for acetone-soluble chlorophyll derivatives which are regarded as the source material of the major porphyrins in crude oils. For quantitative estimation, the pigments in sediment extracts were calculated as pheophytin a which is believed to be the most abundant of several similar pigments present. Approximately 120 surface sediment samples were examined: their sources ranged from beach and marsh through various sea-floor environments to the deep sea. Determinations were made for pheophytin, nitrogen, carbonate, and grain size. In addition, detailed analyses of seven cores were made. A dependence of pheophytin content on grain size is evident in surface samples and in cores. The pheophytin content of cores from nearshore basins decreases with depth of burial, the most abrupt change being near the mud-water interface. Deeper basins farther offshore show only slight decreases in pheophytin with depth of burial. Aside from the marsh deposit, the highest concentration of pheophytin occurs in the shallow basins that contain water having a low oxygen content. The data indicate that the pheophytin content of sediments is almost independent of the production rate of chlorophyll-containing plankton and of dilution with sediments--other than coarse-grained turbidity-current deposits. Instead, the chief factor controlling its abundance appears to be the amount of decomposition undergone in settling through the water column and before burial in the sediment. The decomposition is controlled primarily by water depth, oxygen content of the water, and bottom topography. The chlorophyll derivatives found in sediments are intermediate in structure between chlorophyll and the porphyrins found in petroleum. Magnesium has been lost but vanadium and nickel have not yet been introduced into the pigments. Further changes in the organic structure which must occur to convert these pigments into those found in petroleum involve simple reactions such as reduction of carbonyl groups, hydrogenation of carbon-carbon double bands, dehydrogenation, and decarboxylation. All of these changes may be expected to occur gradually in the sedimentary environment. Chlorophyll derivatives in basin sediments are intermediate in quantity as well as structure between those of phytoplankton and those of petroleum. If as much as 1% of the pigments preserved in the surface zones of basin sediments are eventually converted to the porphyrins found in petroleum, the amounts are ample to furnish crude oils with a normal porphyrin content. End_Page 925------------------------------
Cross-cultural adaptation and content validity of the Adverse Events Associated with Nursing Practices instrument.

OBJECTIVE To conduct the cross-cultural adaptation and evaluate the evidence of content validity of the Adverse Events Associated with Nursing Practices instrument in the Brazilian context. METHOD Psychometric study, conducted between June 2021 and February 2023, following the stages of the Patient-Reported Outcomes Measurement Information System protocol. Semantic, idiomatic, experimental and conceptual equivalences were evaluated, along with content validity evidence, considering Content Validity Ratio (CVR) parameters, with the participation of 25 experts. RESULTS A Brazilian version with 55 items was obtained, demonstrating good linguistic equivalence to the original version (agreement rate=99.2%), and adjustments in the items writing. CVR values remained above 0.60. Cognitive testing indicated good understanding, confirmed by the 31 participants in this stage, with a short application time (average = 17 minutes). CONCLUSION The final version of the instrument showed good linguistic equivalence, strong evidence of content validity and a good response process in the Brazilian context.
The Effects of Rice Husk Ash and Goat Manure Application on the Growth of Mustard Plants (Brassica juncea L.) Varieties Tosakan

Over the past decade, there has been a significant increase in market demand for spinach, rendering its outlook quite promising. However, the optimal growth of spinach has been hindered by low soil fertility. To address this issue, the application of organic materials has been considered to enhance soil fertility, thereby improving the chemical composition of the soil and facilitating the growth of red spinach. This study aims to determine the ideal dosage of rice husk ash and goat manure, as well as the potential interactions between these dosages, to maximize the growth and yield of spinach. The research was conducted in Villa Land, Pasir Mas, situated at an elevation of 26 meters above sea level in the Labuhanbatu district, from August to December 2020. The research design employed a factorial group consisting of two main factors. The first factor, rice husk ash (A), encompassed four levels: A0 = 0 ton/ha (control), A1 = 1 ton/ha (equivalent to 50 g/m2, the recommended dose), A2 = 1.5 tons/ha (equivalent to 75 g/m2), and A3 = 2 tons/ha (equivalent to 100 g/m2). The second factor, goat manure application (K), comprised three levels: K0 = 0 ton/ha (control), K1 = 2 ton/ha (equivalent to 200 g/m2, the recommended dose), K2 = 4 ton/ha (equivalent to 400 g/m2), and K3 = 6 ton/ha (equivalent to 600 g/m2). The parameters measured included plant height (cm), the number of leaves (strands), and weight per plant sample (g). The findings revealed that the application of 4 tons/ha of goat manure, equivalent to 400 g/m2, significantly increased plant height, the number of leaves, and the weight per plant of spinach. Additionally, the provision of 1.5 tons/ha of rice husk ash, equivalent to 75 g/m2, positively impacted plant height and the number of leaves in spinach plants.
Suggested criteria for hydrologic design of storm-drainage facilities in the San Francisco Bay Region, California

This report presents basic criteria, in the form of tables and graphs, for each of the four methods of hydrologic design most commonly used in the San Francisco Bay region--flood-frequency analysis, Rational Method, unit-hydrograph method, and runoff simulation by means of hydrologic basin modeling. The term "hydrologic design" as used in this report refers to the computation of either design values of peak discharge or design hydrographs of storm runoff. The hydraulics of open-channel and pipeline flow and the actual design of appurtenances for conveying the runoff are not discussed in this paper. Use of the suggested criteria results in fairly close agreement between peak discharges computed by the flood-frequency and unit-hydrograph methods. Those peak discharges are not directly comparable with discharges computed by the Rational Method, in part because the results obtained by the Rational Method are affected by the values assigned to parameters for overland and channe l flow. Those parameters are additional to the ones used in the flood-frequency and unit-hydrograph methods. A demonstration of runoff simulation by use of a hydrologic basin model is beyond the scope of this paper--such demonstrations are found in the appropriate references cited. However, thi s report does present an original technique for transposing storm rainfall in the region, storm transposition being commonly required to obtain the precipi~ation input used with hydrologic basin models.
Needs Analysis Of Expressive Art Therapy Counselling Module On Mental Health, Resilience, And Attitudes Towards Seeking Counselling Among Teacher Education Institute

Expressive arts therapy is an approach that combines various artistic modalities such as painting, sketching, sculpture, dance, movement, music, drama, poetry, or prose with the creative process. The aim of this study is to identify the needs of the Expressive Arts Therapy counseling module. This study uses interview methods and a short survey of three experts. The qualitative method uses an interview protocol prepared by the researcher. At the same time, the research questions were developed with five statements. The interview data was analyzed using a thematic approach, while the survey data was analyzed using a descriptive method. The results of the study show that there are three themes: There is no structured and specific module used by counselors, especially in relation to mental health problems. Counselors use the modules based on the cases they receive and the skills they have. The three experts agree on a theoretical consensus, and a creative approach will encourage the involvement of trainee teachers in counseling. Counselling application Expressive arts therapy can be one of the interventions to reduce mental health problems, resilience, and the attitude to seek counseling. Further research proposals should focus on module development design and overall implementation through experimental studies.