Miracle-dz/UniFAR-FTUs huggingface dataset:
Balancing the Growth Performance and Nutritional Value of Edible Farm-Raised Sago Palm Weevil (Rhynchophorus ferregineus) Larvae by Feeding Various Plant Supplemented-Sago Palm Trunk Diets

Herein, the effect of supplementing ground sago palm trunk (GSPT) with varying concentrations of plant-based ingredients (PIs), including rice bran (RB), soybean meal (SM), and perilla seed (PS), on the nutritional profile of sago palm weevil larvae (SPWL) was investigated. Increased PS intake induced an increase in α-linolenic acid level and a reduction in the n-6/n-3 ratio in SPWL (p < 0.05). The presence of fatty acids in SPWL was determined predominantly by the fatty acid profile in the feed. The activities of Δ5 + Δ6 desaturases and thioesterase were not different among SPWL fed different diets (p < 0.05); however, PI intake resulted in low suppression of fads2 gene expression. RB, SM, and PS at the appropriate concentrations of 17.5%, 8.8%, and 7.0% in GSPT (F3 diet), respectively, boosted both protein quantity and quality of SPWL, as indicated by higher levels of essential amino acids, particularly lysine, than the FAO protein reference. Therefore, incorporating PIs into a regular diet is a viable method for enhancing the nutritional value and sustainability of farm-raised SPWL as a potential alternative source of high-quality lipid and protein.
Restricted O2 consumption in pea roots induced by hexanoic acid is linked to depletion of Krebs cycle substrates.

Plant roots are exposed to hypoxia in waterlogged soils, and they are further challenged by specific phytotoxins produced by microorganisms in such conditions. One such toxin is hexanoic acid (HxA), which, at toxic levels, causes a strong decline in root O2 consumption. However, the mechanism underlying this process is still unknown. We treated pea (Pisum sativum L.) roots with 20 mM HxA at pH 5.0 and 6.0 for a short time (1 h) and measured leakage of key electrolytes such as metal cations, malate, citrate and nonstructural carbohydrates (NSC). After treatment, mitochondria were isolated to assess their functionality evaluated as electrical potential and O2 consumption rate. HxA treatment resulted in root tissue extrusion of K+ , malate, citrate and NSC, but only the leakage of the organic acids and NSC increased at pH 5.0, concomitantly with the inhibition of O2 consumption. The activity of mitochondria isolated from treated roots was almost unaffected, showing just a slight decrease in oxygen consumption after treatment at pH 5.0. Similar results were obtained by treating the pea roots with another organic acid with a short carbon chain, that is, butyric acid. Based on these results, we propose a model in which HxA, in its undissociated form prevalent at acidic pH, stimulates the efflux of citrate, malate and NSC, which would, in turn, cause starvation of mitochondrial respiratory substrates of the Krebs cycle and a consequent decline in O2 consumption. Cation extrusion would be a compensatory mechanism in order to restore plasma membrane potential.
Effects of gelatin concentration and co-plasticizer type on physical, mechanical and microstructural properties of corn starch-gelatin composite edible films

In the current study, corn starch-gelatin composite edible films varying in gelatin content (0, 5, 20%) were prepared by using glycerol, and citrate esters; tributyl citrate (TBC) or triisodecyl citrate (TIDC). Edible films formulated with different gelatin concentration and co-plasticizer type were characterized in terms of physical, mechanical, microstructural properties and FTIR spectra. Gelatin addition and increasing the gelatin concentration in the film formulation provided significant increases in surface hydrophobicity and tensile strength and significant decreases in thickness, and elongation at break values. Although the addition of gelatin significantly decreased the ΔE values, gelatin concentration did not affect the ΔE values of edible films. Co-plasticizer addition to the film formulation significantly increased the WCA, and elongation at break values, whereas it significantly decreased the thickness, ΔE and tensile strength values. Co-plasticizer type did not significantly affect the thickness, ΔE, WCA, and tensile strength of edible films. Gelatin addition to the film formulation increased the peak intensity at 1640 cm−1, 1550 cm−1 and 1240 cm−1 bands and decreased the peak intensity at around 1000 cm−1 band. According to the SEM results, addition of gelatin and/or co-plasticizer provided more compact and denser microstructure to the edible films. Overall, gelatin and co-plasticizer addition led to produce thinner edible films with more hydrophobic surface, more transparent appearance, and more ordered microstructure.
Investigating Speaking Anxiety Among Pre-Service ESL Teachers in Oral Presentation

The purpose of this study was to categorise the factors that cause speaking anxiety among pre-service ESL teachers during their oral presentations. There were 10 pre-service ESL teachers involved in this qualitative case study. The 10 pre-service ESL teachers were selected through purposive sampling from a private higher learning institution, took part in a semi-structured interview discussion. The results of the study revealed nine main categories of the factors that cause the pre-service ESL teachers during oral presentations: communication apprehension, fear of negative evaluation, test anxiety, students’ beliefs, self-perceptions, feelings, technological anxiety, technological anxiety, topic/content anxiety and stressful classroom environment. This study asserts that educators should have a sense of awareness about the oral presentation anxiety to plan the teaching and learning in oral presentation classroom. Educators should also employ inclusive, sensitive, and responsive English instructional programs. This study presents an implication in accordance with the curriculum development of speaking course in higher education, including the need to reformulate the speaking course curriculum, emphasizing the integration of technology to arouse the spirits among pre-service English teachers in speaking English
Predictors of survival among patients with chronic hepatitis C at a tertiary care center in Oman

Abstract Background: Chronic hepatitis C (CHC) is a leading cause of cirrhosis and hepatocellular carcinoma (HCC) worldwide. This study aimed to determine rates and predictors of survival among Omani patients with CHC at a tertiary hospital in Muscat, Oman. Methods: This ambidirectional cohort study included all CHC patients who presented to the Sultan Qaboos University Hospital between January 2009 and December 2017. Baseline demographic, clinical, laboratory, and radiological data were analyzed. Patients were followed-up until death or the endpoint of the study (April 2022) to determine survival and associations with other parameters. Results: A total of 702 CHC patients were included, of which 398 (56.7%) were under 50 years of age and 477 (67.9%) were male. Overall, 180 patients (25.6%) died by the study endpoint. The mean duration of follow-up was 93.3 ± 48.0 months. The 5-year survival rate was estimated to be 80.5%, while the 10-year survival was 73%. Sustained virological response and the absence of diabetes mellitus, chronic kidney disease, HCC, or other malignancies were associated with significantly better overall survival. The 3- and 5-year survival rate of patients with hepatitis C virus (HCV)-related HCC was 46.5% and 27.6%, respectively, with a median survival of 29.5 months. Co-infection with hepatitis B was associated with poor survival among this subgroup; conversely, early HCV screening and the presence of a single HCC lesion were associated with better overall survival. Conclusions: National policies for early CHC screening and rapid treatment are needed to improve survival rates in this population.
Validation of a Virtual Environment to Induce State Social Physique Anxiety in Women with Obesity and Social Physique Anxiety

State Social Physique Anxiety (SPA), in contrast to Trait SPA, is triggered by specific situations that elicit SPA. To date, no research has used virtual reality (VR) to recreate a situation that may elicit State SPA. The purpose of this study is to validate a virtual environment (VE) that simulates an anxiogenic situation to induce State SPA in women with obesity and high SPA. The high SPA group consisted of 25 self-identified women living with obesity and high Trait SPA. The low SPA group consisted of 20 self-identified women with low SPA. All participants were immersed in a virtual swimming pool environment for 10 min using a virtual reality headset. After the immersion, State SPA and fear of being negatively judged felt during immersion were measured with self-report questionnaires. A questionnaire assessing unwanted negative side effects was administered before and after the immersion. Using an ANCOVA with Trait SPA as covariate, State SPA was found to be significantly higher in the high SPA group. Fear of being judged negatively was also significantly higher in the high SPA group. Unwanted negative side effects scores did not increase post-immersion in either group. This study documents the validity of a novel VE for inducing State SPA in women with obesity and high SPA.
Climate Change Impact on the Flowering Season of Japanese Cherry (Prunus serrulata var. spontanea) in Korea during 1941-2100

A thermal time-based two-step phenological model was used to project flowering dates of Japanese cherry in South Korea from 1941 to 2100. The model consists of two sequential periods: the rest period described by chilling requirement and the forcing period described by heating requirement. Daily maximum and minimum temperature are used to calculate daily chill units until a pre-determined chilling requirement for rest release is met. After the projected rest release date, daily heat units (growing degree days) are accumulated until a pre-determined heating requirement for flowering is achieved. Model calculations using daily temperature data at 18 synoptic stations during 1955-2004 were compared with the observed blooming dates and resulted in 3.9 days mean absolute error, 5.1 days root mean squared error, and a correlation coefficient of 0.86. Considering that the phonology observation has never been fully standardized in Korea, this result seems reasonable. Gridded data sets of daily maximum and minimum temperature with a 270 m grid spacing were prepared for the climatological years 1941-1970 and 1971-2000 from observations at 56 synoptic stations by using a spatial interpolation scheme for correcting urban heat island effect as well as elevation effect. A 25km-resolution temperature data set covering the Korean Peninsula, prepared by the Meteorological Research Institute of Korea Meteorological Administration under the condition of Inter-governmental Panel on Climate Change-Special Report on Emission Scenarios A2, was converted to 270 m gridded data for the climatological years 2011-2040, 2041-2070 and 2071-2100. The model was run by the gridded daily maximum and minimum temperature data sets, each representing a climatological normal year for 1941-1970, 1971-2000, 2011-2040, 2041-2070, and 2071-2100. According to the model calculation, the spatially averaged flowering date for the 1971-2000 normal is shorter than that for 1941-1970 by 5.2 days. Compared with the current normal (1971-2000), flowering of Japanese cherry is expected to be earlier by 9, 21, and 29 days in the future normal years 2011-2040, 2041-2070, and 2071-2100, respectively. Southern coastal areas might experience springs with incomplete or even no Japanese cherry flowering caused by insufficient chilling for breaking bud dormancy.
Tourism Monitoring as a Strategic Tool for Tourism Management: The Perceptions of Entrepreneurs from Centro de Portugal

Gathering information on the impact of tourism in territories is fundamental for the responsible management of tourism businesses and destinations. Therefore, it is important to monitor tourism performance using indicators that can assess its impacts. Monitoring tourism is a management technique that should adopt a stakeholder network perspective, i.e., all stakeholders should be involved and collaborate with each other by sharing information to increase the competitiveness of the destination. However, it is unclear whether stakeholders are aware of the importance of monitoring and whether monitoring considers their interests, which often leads to a lack of involvement. In this study, we adopt the stakeholder network perspective with tourism entrepreneurs from Centro de Portugal, where we aimed to evaluate the importance assigned to the monitoring of tourism and to the understanding of entrepreneurs’ information needs. To do so, the same survey was conducted twice, for the first time in 2018 and later repeated in 2022. The second survey sought to analyze whether tourism entrepreneurs’ perceptions changed after the COVID-19 pandemic. We found that tourism entrepreneurs valued the economic area more than the social and environmental ones in both periods. Nevertheless, from 2018 to 2022, entrepreneurs became more committed to monitoring tourism in Centro de Portugal.
Amyloid-Beta Peptides Trigger Premature Functional and Gene Expression Alterations in Human-Induced Neurons

Alzheimer’s disease (AD) is the most prevalent cause of dementia in the elderly, characterized by the presence of amyloid-beta (Aβ) plaques, neurofibrillary tangles, neuroinflammation, synapse loss and neurodegeneration in the brain. The amyloid cascade hypothesis postulates that deposition of Aβ peptides is the causative agent of AD pathology, but we still lack comprehensive understanding of the molecular mechanisms connecting Aβ peptides to neuronal dysfunctions in AD. In this work, we investigate the early effects of Aβ peptide accumulation on the functional properties and gene expression profiles of human-induced neurons (hiNs). We show that hiNs acutely exposed to low concentrations of both cell-secreted Aβ peptides or synthetic Aβ1–42 exhibit alterations in the frequency of calcium transients suggestive of increased neuronal excitability. Using single-cell RNA sequencing, we also show that cell-secreted Aβ up-regulates the expression of several synapse-related genes and down-regulates the expression of genes associated with metabolic stress mainly in glutamatergic neurons and, to a lesser degree, in GABAergic neurons and astrocytes. These neuronal alterations correlate with activation of the SEMA5, EPHA and NECTIN signaling pathways, which are important regulators of synaptic plasticity. Altogether, our findings indicate that slight elevations in Aβ concentrations are sufficient to elicit transcriptional changes in human neurons, which can contribute to early alterations in neural network activity.
LEARNet: Dynamic Imaging Network for Micro Expression Recognition

Unlike prevalent facial expressions, micro expressions have subtle, involuntary muscle movements which are short-lived in nature. These minute muscle movements reflect true emotions of a person. Due to the short duration and low intensity, these micro-expressions are very difficult to perceive and interpret correctly. In this paper, we propose the dynamic representation of micro-expressions to preserve facial movement information of a video in a single frame. We also propose a Lateral Accretive Hybrid Network (LEARNet) to capture micro-level features of an expression in the facial region. The LEARNet refines the salient expression features in accretive manner by incorporating accretion layers (AL) in the network. The response of the AL holds the hybrid feature maps generated by prior laterally connected convolution layers. Moreover, LEARNet architecture incorporates the cross decoupled relationship between convolution layers which helps in preserving the tiny but influential facial muscle change information. The visual responses of the proposed LEARNet depict the effectiveness of the system by preserving both high- and micro-level edge features of facial expression. The effectiveness of the proposed LEARNet is evaluated on four benchmark datasets: CASME-I, CASME-II, CAS(ME)^2 and SMIC. The experimental results after investigation show a significant improvement of 4.03%, 1.90%, 1.79% and 2.82% as compared with ResNet on CASME-I, CASME-II, CAS(ME)^2 and SMIC datasets respectively.
Sustainability by Reduced Energy Consumption during Manufacturing: The Case of Cosmetic Emulsions

Energy input in emulsion manufacturing comprises thermal and mechanical energy, with thermal energy being predominant. In terms of raw material selection, there is a widely accepted belief that natural formulations are more “eco-friendly” than their standard (not natural) counterparts. The aim of this study was to compare the energy consumption and subsequent carbon footprint resulting from the production of two main emulsion types, each represented by its standard and natural variant and made by using different manufacturing processes (hot, hot-cold and cold). This resulted in six samples of oil-in-water (O/W) and water-in-oil (W/O) emulsion types, respectively. Scale-down calculations were used to establish the required homogenisation time and speed of the laboratory homogeniser, necessary to achieve the same shear rates as the chosen industrial vessel. The resulting emulsions were characterised using rheological and textural analysis. The six emulsions within each emulsion type have exhibited sufficiently similar characteristics for the purpose of carbon footprint comparisons. Calculations were conducted to quantify the energy input of hot and hot-cold procedures, followed by cradle-to-gate life cycle analysis (LCA). Energy calculations demonstrated that the hot-cold manufacturing process saved approximately 82% (for O/W) and 86% (for W/O) of thermal energy in comparison to the hot process. LCA has shown that the effects of using natural instead of standard ingredients were negative, i.e., it led to a higher carbon footprint. However, it was dwarfed by the effect of the energy used, specifically thermal energy during manufacturing. This strongly indicates that the most efficient way for companies to reduce their carbon footprint is to use the hot-cold emulsification process.
The Nature of Bullying in Higher Education: A Comparative Study of Students’ Experiences in Ghana and Norway

The purpose of this study was twofold: (a) to identify the negative behaviors that constitute bullying in higher education as reported by students, and (b) to explore differences in student experiences in two markedly different national contexts. A sample of 1,189 respondents from two universities in Ghana (n = 751) and two universities in Norway (n = 438) answered the same questionnaire. Approximately 40% of the Ghanaian students and 20% of the Norwegian students responded that they had been bullied. Although less frequently observed than in Ghana, relational forms of bullying (e.g., being excluded) were more prevalent in Norway compared to other behaviors. In contrast, direct and verbal forms of bullying, such as name-calling and being taunted, were most common in Ghana. The findings provide insights into cultural and national variations with respect to negative social behaviors related to bullying in the context of higher education.
Association Between Monocyte-to-High-Density Lipoprotein (HDL) Cholesterol Ratio and Proteinuria in Patients With Type 2 Diabetes Mellitus: A Prospective Observational Study

Background Diabetes mellitus (DM) refers to a group of metabolic disorders that share the phenotype of hyperglycemia. “Diabetic nephropathy (DN)" is a microvascular complication of DM, and it is the leading cause of end-stage renal failure. Increased urinary albumin excretion (UAE) and a decrease in glomerular filtration rate (GFR) are associated with DN along with elevated blood pressure and end-stage renal disease (ESRD). The purpose of this study is to analyze the prognostic significance of the monocyte-to-high-density lipoprotein (HDL) cholesterol ratio (MHR) in DN patients. Materials and methods This prospective observational study was carried out over a period of 1.5 years, with patients being followed up for three months. One hundred twenty participants were enrolled and allotted into groups based on the measure of urine albumin-to-creatinine ratio (UACR). The participants were categorized into healthy individuals, normoalbuminuric diabetic patients, microalbuminuric diabetic patients, and macroalbuminuric diabetic patients group. The MHR, neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) were estimated and compared between the baseline measurements. Conclusion The MHR, NLR, and PLR showed a positive correlation with UACR levels which could serve as an inflammatory marker and be used as an inexpensive and accessible prognostic marker in DN patients.
Folate-receptor-targeted co-self-assembly carrier-free gemcitabine nanoparticles loading indocyanine green for chemo-photothermal therapy

The carrier-free chemo-photothermal therapy has become a promising strategy to improve anti-cancer therapeutic efficacy owing to the combination of chemotherapy and photothermal therapy, with improved chemotherapy drug pharmacodynamics and pharmacokinetics, high drug loading, and reduced toxicity. We designed a novel carrier-free targeting nanoparticles, co-self-assembled amphiphilic prodrugs 3′,5′-dioleoyl gemcitabine (DOG), and tumor-targeted γ-octadecyl folate (MOFA), with encapsulated US Food and Drug Administration (FDA)-approved photosensitizer indocyanine green (ICG) for synergistic chemo-photothermal therapy. The DOG linking oleic acid to the sugar moiety of gemcitabine (GEM) showed better self-assembly ability among GEM amphiphilic prodrugs linking different fatty acids. The readily available and highly reproducible 3′,5′-dioleoyl gemcitabine/γ-octadecyl folate/indocyanine green (DOG/MOFA/ICG) nanoparticles were prepared by reprecipitation and showed nano-scale structure with mono-dispersity, great encapsulation efficiency of ICG (approximately 74%), acid- and laser irradiation-triggered GEM release in vitro and sustained GEM release in vivo after intravenous administration as well as excellent temperature conversion (57.0°C) with near-infrared laser irradiation. The combinational DOG/MOFA/ICG nanoparticles with near-infrared laser irradiation showed better anti-tumor efficacy than individual chemotherapy or photothermal therapy, with very low hemolysis and inappreciable toxicity for L929 cells. This co-self-assembly of the ICG and the chemotherapy drug (GEM) provides a novel tactic for the rational design of multifunctional nanosystems for targeting drug delivery and theranostics.
On Analysis of Network Coding-Based One-Shot Random Access for Low-Latency MTC

For low-latency communication in massive machine-type communication (MTC), since re-transmissions may not be allowed, one-shot random access (OSRA) such as <inline-formula><tex-math notation="LaTeX">$K$</tex-math></inline-formula>-repetition or network coding (NC)-based OSRA can be considered. In our previous study, it was shown that NC-based OSRA can always perform better than <inline-formula><tex-math notation="LaTeX">$K$</tex-math></inline-formula>-repetition for some limited cases. In this article, more realistic conditions are considered to derive the packet loss rate (PLR) of NC-based OSRA for a fair performance comparison in terms of PLR. Interestingly, it is shown that <inline-formula><tex-math notation="LaTeX">$K$</tex-math></inline-formula>-repetition can outperform NC-based OSRA when the traffic intensity is sufficiently low, which might be necessary to provide a high reliability in terms of PLR. For a low-medium traffic intensity, the PLR of NC-based OSRA is lower than that of <inline-formula><tex-math notation="LaTeX">$K$</tex-math></inline-formula>-repetition. Simulations are also carried out to confirm our derivations.