Miracle-dz/UniFAR-FTUs huggingface dataset:
CARBORANYLANILINOQUINAZOLINE EGFR-INHIBITORS: TOWARDS “LEAD-TO-CANDIDATE” STAGE IN THE DRUG-DEVELOPMENT PIPELINE

 Abstract: Background: Carboranylanilinoquinazoline-hybrids, developed for BNCT, have demonstrated cytotoxicity against murine-glioma cells with EGFR-inhibition ability. In addition, their adequate aqueous/metabolic stabilities and ability to cross BBB make them good leads as to become anti-glioma drugs. Aim: Analyze drug-like-properties of representative carboranylanilinoquinazolines. Methods: To expand carboranylanilinoquinazolines therapeutic spectrum, we studied their ability to act against glioma-mammal cells, U-87 MG, and other tyrosine kinase-overexpress cells, HT-29. Additionally, we predicted theoretically and studied experimentally drug-like-properties, i.e. OECD-recommended toxicity-studies and, due to some aqueous-solubility problems, and vehicularization for oral and intravenous administrations. Conclusion: We have identified a promising drug-candidate with broad activity spectrum, appropriate drug-like properties, adequate toxicological behavior, and able to be loaded in suitable vehicles.
Simulation of the Interdecadal Pacific Oscillation and its impacts on the climate over eastern China during the last millennium

The Interdecadal Pacific Oscillation (IPO) and its impacts on precipitation over eastern China during the last millennium are investigated through analyzing two 1000 year global climate model simulations. Results show that the model does not simulate a prolonged period of negative IPO before A.D. 1300 suggested by the proxy reconstruction, although it does simulate centennial periods of negative and positive IPO. The simulated IPO exhibits several low‐frequency oscillations, including 10–23, 30–33, 35–70, and 85–110 years. However, it remains an open question whether simulated IPO oscillations longer than bidecadal mode can be or not be considered as essentially internal modes of variability. The simulations indicate that precipitation over eastern China is associated with the IPO. When the strongest IPO signal of 53–77 year oscillation occurs, the summer precipitation goes of opposite sign over North China (NC) and the middle and lower Yangtze River Vally (MLYRV), i.e., dipole mode such as the “flood‐in‐south and drought‐in‐north” pattern that occurs during the positive IPO episodes and vice versa. While coherent mode is dominant when the relatively weak IPO signal occurs, and warm phases of the IPO coincide with coherent drought and vice versa. The association between 53–77 year oscillation of the IPO and precipitation in NC is more marked than that in the MLYRV. Our results suggest that the internal variability of climate system like the IPO may play an important role in precipitation over eastern China, at least on the 53–77 year oscillation.
Mid‐Devonian movements in the Northeastern Lachlan Fold Belt

Abstract Calculations of the angular discordance between the Upper Devonian Lambie/Catombal Groups and underlying Lower Devonian formations at 130 separate locations in six areas in the northeastern Lachlan Fold Belt show that the unconformity is of a low angle except for one locality, near Limekilnes (100°). Fewer than 3% of the calculated angular discordances exceed 30°, and 73%” are less than 20°. Attempts to discover a mid‐Devonian fold direction from the restored orientation of the Lower Devonian beds, after the Upper Devonian beds have been rotated to horizontal, have been unsuccessful. Scatter of the restored bedding poles, either primary, or introduced by deformation or imprecision inherent in the measurement technique, camouflages any consistent mid‐Devonian fold axis. Although there was demonstrable uplift, tilting, and erosion in the mid‐Devonian, limb dips on any mid‐Devonian folds do not exceed 30°. From consideration of our data, and the interpretation of angular unconformities, we conclude .
Title: recent insights on the genetics and epigenetics of endometriosis

Endometriosis is a gynecologic disease affecting up to 10% of the women and a major cause of pain and infertility. It is characterized by the implantation of functional endometrial tissue at ectopic positions generally within the peritoneum. This complex disease has an important genetic component with a heritability estimated at around 50%. This review aims at providing recent insights into the genetic bases of endometriosis, and present a detailed overview of evidence of epigenetic alterations specific to this disease. In the future, these alterations may constitute therapeutic targets for pharmacological compounds able to modify the epigenetic code. histone deacetylation of its promoter in isolated cells from endometriosis cysts stroma, compared to normal endometrial stromal cells. Treatment with
Evaluation of the Effects of Water Stress and Different Levels of Nitrogen on Sugar Beet (Beta Vulgaris)

In order to investigate the effects of water stress and different levels of N fertilizer on yield and water use efficiency in sugar beet (Var. BP) a split plots based on randomized complete block design was carried out with 4 replications in Khorasan Agricultural and Natural Resources Research Center (KANRC) during cropping season in 2006. Water treatments comprising three levels including control (without water stress), initial water stress and continuous water stress as main plots and different amounts of N fertilizer in 4 levels vis: control (0), 50, 100 and 150 Kg net N. ha-1 as sub plots were assessed. Analysis of variation showed that effects of water treatments on root yield and gross sugar content was significant (at 1% level). Different levels of N also have significant effect on root yield, net and gross sugar percent at 1% level while didn't influence net sugar yield significantly. Interaction of water and N wasn’t significant for all the traits. Water use efficiency for root (WUEr) and for sugar (WUEs) were significant in irrigation amounts (P< 0.05) However, results showed that increased root yield under no water stress conditions with increased N amount was much more than it in water stress conditions. In terms of root yield, no water stress treatment using 150 Kg Net N.ha-1 had the highest yield. But water stress treatment particularly constant water stress, caused the maximum water use efficiency.
Enhanced removal of groundwater‐borne nitrate in heterogeneous aquatic sediments

Anthropogenic nitrate loads to rivers and coasts deteriorate coastal water quality. The primary sink for nitrate is denitrification in aquatic sediments. Here I show that nitrate removal rates in upwelling groundwater are as much as 60 times more efficient in heterogeneous than equivalent homogeneous aquatic sediments, even when travel times are the same. Coupled flow and reactive transport simulations were used to quantify the removal of groundwater‐borne nitrate in aquatic sediments with sand and silt structures that represent infilled burrows, rip‐up clasts, or other core‐scale features. In silt structures with greater organic carbon content and microbial biomass, aerobic respiration consumes oxygen, creating localized zones of denitrification that would not otherwise exist in homogeneous sediments. While hot spots of denitrification have previously been shown to form in organic‐rich aggregates in soils and sediments, this study is the first to quantify their potentially large influence on groundwater‐borne nitrate loads to surface waters.
Constraints on the composition of ore fluids and implications for mineralising events at the Cleo gold deposit, Eastern Goldfields Province, Western Australia

The Cleo gold deposit, 55 km south of Laverton in the Eastern Goldfields Province of Western Australia, is characterised by banded iron‐formation (BIF)‐hosted ore zones in the gently dipping Sunrise Shear Zone and high‐grade vein‐hosted ore in the Western Lodes.There is evidence that gold mineralisation in the Western Lodes (which occurred at ca 2655 Ma) post‐dates the majority of displacement along the Sunrise Shear Zone, but it remains uncertain if the ore in both structures formed simultaneously or separately. Overall, the Pb, Nd, Sr, C, O and S isotopic compositions of ore‐related minerals from both the Western Lodes and ore zones in the Sunrise Shear Zone are similar. Early low‐salinity aqueous‐carbonic fluids and late high‐salinity fluids with similar characteristics are trapped in inclusions in quartz veins from both the Sunrise Shear Zone and the Western Lodes. The early CO2, CO2–H2O, and H2O‐dominant inclusions are interpreted as being related to ore formation, and to have formed from a single low‐salinity aqueous‐carbonic fluid as a result of intermittent fluid immiscibility. Homogenisation temperatures indicate that these inclusions were trapped at approximately 280°C and at approximately 4 km depth, in the deeper epizonal range. Differences between the ore zones are detected in the trace‐element composition of gold samples, with gold from the Sunrise Shear Zone enriched in Ni, Pb, Sn, Te and Zn, and depleted in As, Bi, Cd, Cu and Sb, relative to gold from the Western Lodes. Although there are differences in gold composition between the Sunrise Shear Zone and Western Lodes, and hence the metal content of ore fluids may have varied slightly between the different ore zones, no other systematic fluid or solute differences are detected between the ore zones. Given the fact that the ore fluids in each zone have very similar bulk properties, the considerable differences in gold grade, sulfide mineral abundance, and ore textures between the two ore zones most likely result from different gold‐deposition mechanisms. The association of ore zones in the Sunrise Shear Zone with pyrite‐replaced BIF suggests that wall‐rock sulfidation was the most significant mechanism of gold precipitation, through the destabilisation of gold‐bisulfide complexes. The Western Lodes, however, do not exhibit any host‐rock preference and multistage veins commonly contain coarse‐grained gold. Fluid‐inclusion characteristics and breccia textures in veins in the Western Lodes suggest that rapid pressure changes, brought about by intermittent release of overpressured fluids and concomitant phase separation, are likely to have caused the destabilisation of gold‐thiocomplexes, leading to formation of higher‐grade gold ore zones.
Disruption of Functional Connectivity in Clinically Normal Older Adults Harboring Amyloid Burden

Amyloid deposition is present in 20–50% of nondemented older adults yet the functional consequences remain unclear. The current study found that amyloid accumulation is correlated with functional disruption of the default network as measured by intrinsic activity correlations. Clinically normal participants (n = 38, aged 60–88 years) were characterized using 11C-labeled Pittsburgh Compound B positron emission tomography imaging to estimate fibrillar amyloid burden and, separately, underwent functional magnetic resonance imaging (fMRI). The integrity of the default network was estimated by correlating rest-state fMRI time courses extracted from a priori regions including the posterior cingulate, lateral parietal, and medial prefrontal cortices. Clinically normal participants with high amyloid burden displayed significantly reduced functional correlations within the default network relative to participants with low amyloid burden. These reductions were also observed when amyloid burden was treated as a continuous, rather than a dichotomous, measure and when controlling for age and structural atrophy. Whole-brain analyses initiated by seeding the posterior cingulate cortex, a region of high amyloid burden in Alzheimer's disease, revealed significant disruption in the default network including functional disconnection of the hippocampal formation.
El tránsito Aragoniense-Vallesiense en el área de Daroca-Nombrevilla (Zaragoza, España)

A pesar del extenso registro fosil del Mioceno espanol, es escaso el conocimiento de yacimientos provenientes de depositos que cubran el transito Aragoniense-Vallesiense. Durante los ultimos anos, nuevos muestreos paleontologicos se han llevado a cabo en el area de Daroca (Zaragoza, Espana) para completar la informacion sobre este intervalo. Ademas se han realizado estudios litoestratigraficos y muestreos magnetoestratigraficos. El resultado de dichos estudios pone de manifiesto la existencia, en el area de Daroca-Nombrevilla, de una seccion estratigrafica que incluye quince yacimientos fosiliferos (de los cuales nueve son de reciente hallazgo) y que viene a completar el conocimiento del registro fosil del Aragoniense superior-Vallesiense inferior. [ABSTRACT] Despite the extensive continental fossil record from the Spanish Miocene, few localities from deposits covering the Aragonian-Vallesian boundary are known. During the last few years new sampling has been carried out around Daroca (Zaragoza, Spain) in order to complete the information of that interval. In addition, lithostratigraphic and sedimentological studies as well as magnetostratigraphic sampling have been done. The results of all these studies allow to recognise a stratigrafic section that includes fifteen mammal fossil localities (of which nine are new) completing our knowledge of the fossil record of the upper Aragonian-lower Vallesian.
Seasonal stratification and tidal current profiles along Ronne Ice Front

Throughout much of the year a coastal polynya along Ronne Ice Front in the southern Weddell Sea is maintained by winds blowing from Ronne Ice Shelf and tidal divergence [Foldvik et al., 2001; Renfrew et al., 2002]. In wintertime, the coastal polynya is the focus of intense heat loss, as relatively warm water is exposed to the cold atmosphere, causing the seawater to cool to its surface freezing point, with further heat loss resulting in sea ice production. Sustained sea ice production is maintained as newly formed sea ice is transported northward away from the polynya by offshore winds. Production rates are 1 or 2 orders of magnitude higher than for the surrounding sea ice, with typically 6.1 % of the entire Weddell Sea ice production focused within the polynya that makes up only 0.013 % of the Weddell Seas area [Renfrew et al., 2002]. The associated High Salinity Shelf Water (HSSW) production will be equally intense within the polynya resulting in convective overturning of the entire underlying water column during winter [Foldvik et al., 2001; Nicholls et al., 2003] and a strong seasonal signal in the water column properties. Any changes in seasonal stratification are likely to significantly affect the tidal current profile in this region [Makinson, 2002]. It is the strongly depth dependent semi-diurnal tidal currents, associated with the proximity of the critical latitude [Foldvik et al., 2001; Foldvik et al., 1990], that are sensitive to these changes. The northern most part of the Ronne Ice Front region lies near the M2 critical latitude (74° 28' 18"S), which can give rise to a thick bottom boundary layer that may occupy the entire water column. Along the ice front, early observations of tidal currents and water column properties were confined to short summer observations and hence no seasonal data was available. However, four moorings with records greater than one year have been successfully recovered from the Ronne Ice Front coastal polynya [Foldvik et al., 2001; Woodgate et al., 1998]. Initial analysis by Makinson and Schroder [2004] has shown that during periods of stratification, the tidal current profile is notably different from those during the winter. The data from these moorings forms the basis of the work presented here and their locations are shown in Figure 1.
The Utility of Regional Gravity and Magnetic Anomaly Maps

Mapping of the Earths gravity and magnetic fields has a long and distinguished history as part of the investigations of the structure and petrologic variation within the Earths lithosphere. Prior to 1950, observations of anomalies in these planetary fields had gene rally been focused on limited areas for specific mineral-resource and geological objectives. The increasing availability of portable gravimeters and the development of aeromagnetic-survey technology shortiyafter World War II, however, led to efficient and precise gravity and magnetic mapping of extensive regions. These regional surveys were conducted for the most part by governmental organizations most of ten as a means of evaluating or stimulating the exploitation of earth resources. The data from these federal surveys are generally available in the public domain and have been augmented by large amounts of data collected by academic institutions for basic-research investigations. Vast amounts of gravity and magnetic-anomaly data also have been acquired by industrial firms in mineral-resource exploration, but with few exceptions these data are generally not available to the public. In the United States, the publicly available data have recently been composited into new or improved country-wide anomaly maps. In 1975, the Society of Exploration Geophysicists (SEG) and the U.S. Geological Survey, recognizing the value of regional gravity and magnetic-anomaly maps, jointly organized gravity-and magnetic-anomaly map committees to prepare anomaly maps of the United States. The immediate objective of the committe es was to compile and publish a revised gravity-anomaly map of the conterminous United States and the first magnetic-anomaly maps of the conterminous United States and Alaska. These objectives were met in late 1982 with the publication of the Gravity Anomaly Map of the United States by the SEG and the release of the Composite Magnetic Anomaly Map of the Conterminous United States and the Magnetic Anomaly Map of Alaska by the U.S. Geological Survey. Small-scale versions of these maps are reproduced in color in this volume together with the most recently published gravity-and magnetic-anomaly maps of Canada. In recognition of the publication of these national maps, and to illustrate the many uses of gravity-and magnetic-anomaly maps, aseries of special technical sessions was held at the 52nd Annual International Meeting of the SEG in the fall of 1982 in Dallas, Texas. A total of 33 of the 53 papers presented at the special sessions were accepted for publication in this volume, The Utility of Regional Gravity and Magnetic Anomaly Maps.
Anti-tumour immune response in GL261 glioblastoma generated by Temozolamide Immune-Enhancing Metronomic Schedule monitored with MRSI-based nosological images (2020) Anti-tumour immune response in GL261 glioblastoma generated by Temozolamide Immune-Enhancing Metronomic Schedule monitored with MRSI-ba

: Glioblastomas (GB) are brain tumours with poor prognosis even after aggressive therapy. Improvements in both therapeutic and follow-up strategies are urgently needed. In previous work we described an oscillatory pattern of response to Temozolomide (TMZ) using a standard administration protocol, detected through MRSI-based machine learning approaches. In the present work, we have introduced the Immune-Enhancing Metronomic Schedule (IMS) with an every 6-days TMZ administration at 60mg/kg, and investigated the consistence of such oscillatory behaviour. A total of n=17 GL261 GB tumour-bearing C57BL/6j mice were studied with MRI/MRSI every 2 days, and the oscillatory behaviour (6.2±1.5 days period from the TMZ administration day) was confirmed during response. Furthermore, IMS-TMZ produced significant improvement in mice survival (22.5±3.0 days for controls vs 135.8±78.2 for TMZ-treated), outperforming standard TMZ treatment. and 21.9±11.4% suggesting that increased lymphocyte inhibition could be associated to IMS-TMZ failure. Overall, data suggest that host immune response has a relevant paper in therapy response/escape in GL261 tumours under IMS-TMZ therapy. This is associated to changes in the metabolomics pattern, oscillating every 6 days, in agreement with immune cycle length, which is being sampled by MRSI-derived nosological images. suppressor cells; MTX , matrix size; MRI , magnetic resonance imaging; MRS , magnetic resonance spectroscopy; MRSI , magnetic resonance spectroscopic imaging; NA , number of averages; NMF , non-negative matrix factorization; NS , number of slices; PD , progressive disease; PD-1 , programmed death-1; PD-L1 , programmed death-ligand 1; PR , pattern recognition; PRe , partial response; PRESS , point-resolved spectroscopy; PVDF , polyvinylidene fluoride; RANO , response assessment in neuro-oncology; RARE , rapid acquisition with relaxation enhancement; RECIST , response evaluation criteria in solid tumours; ROIs , regions of interest; SDi , stable disease; SDS-PAGE , sodium dodecyl sulfate-polyacrylamide gel electrophoresis; ST , slice thickness; SW , sweep width; T2w , T2 weighted image; TAT , total acquisition time; TE , echo time; TEeff , effective echo time; TMZ , temozolomide; TR , repetition time; TRI , tumour responding index; TV , tumour volume; VAPOR , variable power and optimized relaxation delay; VOI , volume of interest; WB , western blot; wt , wild-type
30+ Winter Seasons Of Operational Cloud Seeding In Utah

North American Weather Consultants (NAWC) has conducted operational winter cloud seeding programs in many of the mountainous areas of Utah since 1974. The goal of these programs has been to enhance winter snowpack accumulation in several mountainous target areas throughout the State. Studies have demonstrated that a large majority of the annual runoff in Utah streams and rivers is derived from melting snowpacks, which explains the focus on wintertime seeding. Augmented water supplies are typically used for irrigated agriculture or municipal water supplies. Programs are typically funded at the county level with cost-sharing grants from the Utah Division of Water Resources. Cloud seeding is accomplished using networks of ground-based, manually operated silver iodide generators located in valley or foothill locations upwind of the intended target mountain barriers. As such, these programs are classified as orographic winter cloud seeding programs. Orographic winter cloud seeding programs are typically categorized as those with the highest level of scientific support based upon capability statements of such organizations as the American Meteorological Society, the World Meteorological Organization, and the Weather Modification Association. NAWC historical target/control evaluations of these Utah programs based upon high elevation precipitation and snow water content observations indicate a range of apparent increases in target area average precipitation or April 1st snow water content of 3-21%. The Utah Division of Water Resources conducted an independent assessment of the seeding programs in 2000. That assessment confirmed the NAWC indicated increases in snow water content, and then took the additional step of estimating the increases in annual streamflow resulting from the estimated increases in snow water content. Average annual increases from four seeded areas were estimated to total 249,600 acre-feet. Factoring in the cost of conducting these programs resulted in an estimate of the average cost of the augmented runoff to be $1.02 per acre-foot.