Miracle-dz/UniFAR-FTUs huggingface dataset:
Beyond αβ T cells: NK, iNKT, and γδT cell biology in leukemic patients and potential for off-the-shelf adoptive cell therapies for AML

Acute myeloid leukemia (AML) remains an elusive disease to treat, let alone cure, even after highly intensive therapies such as stem cell transplants. Adoptive cell therapeutic strategies based on conventional alpha beta (αβ)T cells are an active area of research in myeloid neoplasms given their remarkable success in other hematologic malignancies, particularly B-cell-derived acute lymphoid leukemia, myeloma, and lymphomas. Several limitations have hindered clinical application of adoptive cell therapies in AML including lack of leukemia-specific antigens, on-target-off-leukemic toxicity, immunosuppressive microenvironments, and leukemic stem cell populations elusive to immune recognition and destruction. While there are promising T cell-based therapies including chimeric antigen receptor (CAR)-T designs under development, other cytotoxic lymphocyte cell subsets have unique phenotypes and capabilities that might be of additional benefit in AML treatment. Of particular interest are the natural killer (NK) and unconventional T cells known as invariant natural killer T (iNKT) and gamma delta (γδ) T cells. NK, iNKT, and γδT cells exhibit intrinsic anti-malignant properties, potential for alloreactivity, and human leukocyte-antigen (HLA)-independent function. Here we review the biology of each of these unconventional cytotoxic lymphocyte cell types and compare and contrast their strengths and limitations as the basis for adoptive cell therapies for AML.
The Effect of Stimulants on Nectar Composition, Flowering, and Seed Yield of Common Buckwheat (Fagopyrum esculentum Moench)

Common buckwheat is a valuable plant producing seeds containing a number of health-promoting compounds and elements. Buckwheat does not contain gluten and is characterized by an excellent composition of amino acids. This species is also a melliferous plant. Despite many advantages, the area of buckwheat cultivation is decreasing due to unstable yields. One of the reasons for low seed yield is its sensitivity to drought, high temperatures, and assimilate deficiencies. These factors have a significant impact on the nectar composition, which is important for visiting pollinators and thus for pollination. High temperature during flowering increases the degeneration of embryo sacs and embryos, which is high anyway (genetic determination) in common buckwheat. This phenomenon seems to be unbreakable by breeding methods. The authors aimed to determine whether stimulants commonly used in agriculture could increase the seed yield of this plant species. The aim of the work was to choose from eight different stimulants the most effective one that would improve the seed yield of two accessions of common buckwheat by increasing the efficiency of nectar production and reducing the number of empty seeds. The plants were sprayed at either the beginning of flowering or at full bloom. The content of sugars and amino acids was higher in the nectar produced at the beginning of flowering. The nectar of both lines included also polyamines. The level of sugars in the nectar increased mainly after spraying with the stimulants in the second phase of flowering. A positive correlation between the total amount of sugars and amino acids in the nectar and seed yield was found. All the stimulants used reduced the number of empty seeds in both accessions. Seed production in the PA15 line increased significantly under the influence of all stimulants used at the beginning of flowering, and the most effective were ASAHI SL and TYTANIT®.
COMPARISON OF MIDAZOLAM AND BUPIVACAINE FOR CAUDAL BLOCK IN CHILDREN FOR POST OPERATIVE ANALGESIA

Background: Regional anaesthesia is used widely in children, mostly in conjunction with general anaesthesia to provide balanced anaesthesia and they significantly improve patient comfort in the post operative period. Caudal blocks are the most common regional technique for postoperative pain relief in children. We compared the analgesic efficacy of caudal administration of Bupivacaine vs Midazolam on 50 children (divided into 2 groups) aged 1 – 12 years in ASA I physical status scheduled to undergo elective infraumbilical surgeries. Materials and Methods: 50 children were divided into 2 groups randomly to receive a caudal injection of either 0.25% bupivacaine I ml/Kg or midazolam 50 micrograms/ kg with normal saline 1 ml/kg. Result: A standard General anaesthesia technique was used and caudal block was achieved at the end of the surgery. Group I received Midazolam 50 micrograms\kg, in a volume of 1ml\kg and Group II received Bupivacaine 0.25% 1ml\kg. Short acting opioid was used for intra operative analgesia. There was no difference in quality of pain relief, duration of analgesia and analgesic requirements in both the groups. Side effects, such as motor weakness, nausea and vomiting and urinary retention were not observed in Midazolam group. : It was concluded that caudal Midazolam 50 micrograms\kg provides equivalent analgesia to Bupivacaine 0.25% when administered postoperatively in a volume of 1 ml\kg for children following infraumbilical surgeries. Lesser side effects were observed in the Midazolam group.
Students and higher education institutions relationship: emotional commitment, loyalty and love brand

Objective: The present research purpose consisted of investigate the strength of social and academic integration, perceived quality and trust to emotional commitment to Higher Education Institutions (HEI) and its relationship with loyalty, as well as testing the impact of loyalty to HEI on brand love Methodology: A survey method was applied with undergraduate students from a private HEI (named here as ALPHA) with 3 campuses located in São Paulo, Rio de Janeiro and Porto Alegre, totaling 306 valid questionnaires. Originality: The novelty consisted of replicate an adapted version of the RQSL model using only variables with high predictive power as presented in previous research. Additionally, the brand love construct was added as outcome of the student loyalty. The results demonstrated that the adaptation proved to be a reliable predictive instrument to explain that the students' loyalty to a private HEI is strongly linked to their emotional commitment. Main results: The research showed the strength of three antecedents in the construction of students' emotional commitment to HEI, namely: social and academic integration, perceived quality and trust. Brand love emerged as a significant outcome of student loyalty to a HEI. In this sense, the greater the emotional commitment, the greater the student's loyalty and, consequently, the greater brand love to the HEI. Theoretical Contributions: The results showed that among the four antecedent factors, social integration has a significant force. In this sense, one might consider that feeling of participation in the group and the sense of belonging are considered of great importance by the students, in addition to factors such as quality, trust and academic integration.
International Students’ Satisfaction with Online Learning and Faculty Engagement during the COVID-19 Pandemic in Northwestern Chinese Universities

International students in China had not anticipated the unprecedented disruption to their educational experiences caused by the COVID-19 pandemic. In China, COVID-19 movement control on campus was managed solely by university authorities. Online teaching and learning following multilevel procedures were implemented for centralized emergency response, decision-making, and information dissemination. This study examined international studentsʼ academic and non-academic experiences in northwestern Chinese universities during the pandemic. Kuh’s engagement theory of learning and the Keaveney and Young’s Satisfaction Model were adapted and employed for insights into student satisfaction. The study was informed by Creswell’s “exploratory sequential” mixed methods research design. The in-depth interviews with selected students from three universities with the highest international student intakes in northwest China yielded four factors affecting students’ satisfaction, namely, online learning experience, in class-interaction, out-of-class faculty-students engagement, and out-ofclass student initiative. A validated questionnaire was distributed following the interviews at three universities. 410 international students completed the questionnaire. The analysis revealed a moderate level of satisfaction with both online learning and the faculty-students engagement during the pandemic. However, international students’ expectations differed according to their respective backgrounds and disciplines. Undergraduates yearned for more interpersonal communication, while postgraduate students desired academic engagement during online learning and fulfilment of graduation criteria. These findings should help the universities in Northwest China with strategic planning and the formulation of management policies pertaining to international student satisfaction.
Carbon Cycle: 1985 Glacial to Interglacial Changes in the Operation of the Global Carbon Cycle

The hottest topic for those interested in the earth's carbon cycles is the change in atmospheric CO2 content between glacial and interglacial time. What caused it? What is its role in glacial cycles? We evaluate here the hypotheses that have been put forward to explain the CO2 change with evidence from deep sea sediments. We conclude that all the hypotheses have serious drawbacks and that much effort will have to be expended in gathering more data from ice cores and ocean sediments before we will be pointed toward the correct scenario. Also, thoughtful modeling aimed at depicting the ties between pCO2, O2,13C/12C, 14C/12C, and nutrient constituents in the sea for various modes of circulation will have to be done before the evidence from ocean cores can be properly interpreted.
Learners as Partners in Assessing Course Learning Outcomes in an EFL University Context

Learners’ achievement of Course Learning Outcomes (CLOs) seems to be a common challenge in higher education worldwide, including the EFL university context in Yemen. This might be due to the disengagement of learners as partners in setting and assessing the CLOs. Limited research has been done on the engagement of learners in assessing the achievement of EFL CLOs. Thus, this study aimed to investigate the assessment of the achievement of learning outcomes of one particular course, i.e., advanced reading as perceived and achieved by EFL learners at a private university, namely University of Science and Technology, Yemen. The quantitative approach was adopted to gather data from 81 female EFL students at the university through a 5-point Likert scale checklist of the learning outcomes of the advanced reading course and students’ overall results of the course. The data were analyzed using SPSS.21. Findings revealed that the achievement of CLOs, as perceived by participants, was average, whereas their actual performance was high. The findings also revealed that there was no correlation between learners’ perceived achievement of CLOs and their actual achievement. The study may give insights into higher education institutions about the role of EFL learners in assessing the achievement of CLOs.
EFFECT OF INTERCROPPING ON THE INCIDENCE OF DISEASES OF GROUNDNUT

The effect of intercropping on the incidence of groundnut ring mosaic caused by a strain of Tomato Spotted Wilt Virus (TSWV) could be seen only at 30 days after sowing. Sorghum as intercrop and barrier crop, cumbu as intercrop in groundnut significantly reduced the incidence of ring mosaic, late leaf spot and rust. Sunflower either as intercrop or barrier crop in groundnut was not effective in reducing the incidence of all the three diseases.
The Applicability of Artificial Intelligence in Candidate Interviews in the Recruitment Process

This research paper examines the applicability of artificial intelligence (AI) in the recruitment and selection process, with a specific focus on the Interview phase. The study conducted qualitative interviews with 17 recruitment professionals, including hiring managers, recruiters, and HR executives, to gather their perspectives on AI adoption. The Unified Theory of Acceptance and Use of Technology (UTAUT) framework was utilized as the theoretical model to guide the research. The findings indicate that the recruitment professionals were generally receptive to using AI in various recruitment phases. However, when it came to the interview phase, there was a distinct lack of enthusiasm for AI adoption among the professionals. They expressed concerns about providing a better candidate experience and perceived AI-based interviews as a lack of commitment to candidates. As a result, regardless of the hiring volume or job group, the professionals were hesitant to integrate AI into the interview phase. The research underscores the importance of carefully selecting the appropriate recruitment stage for integrating AI and addressing the concerns raised by recruitment and selection professionals. It highlights the need to consider the candidate's experience and maintain a sense of commitment throughout the recruitment process.
A comparative study of social media networks among higher education students

This study aims to compare how students perceive and use social media networks (SMNs) in both Omani and Russian higher education institutions. An extensive literature survey was conducted through which the content of the questionnaire was compiled in English, validated for its content, clarity and accuracy by Russian and Omani reviewers and then translated. Data was collected from 837 undergraduate Russian and Omani students using online Google Forms. The results indicate a moderate level of SMNs use in both Higher Education Institution (HEIs) contexts with cross-platform mobile applications at the top of list of the SMNs used by both groups for social connections and multimedia sharing. The overall perceptions towards SMNs seem to be neutral among Russian and Omani students followed by positive perceptions. The study recommends that teachers in both countries provide 'attractive' academic content through a social and multimedia design approach.
Study of the morphological characteristics of nanoparticles synthesized by biogenic method

– The green nanotechnology (biogenic method) is recognized for its broad advantages in different branches of the scientific field. In recent years, has been defined as an innovated field, related to the development of methodologies with little environmental contamination. In this research, the PRISMA methodology was applied, considered some selection criteria (Open access, language, quartile), obtaining a total of 31 investigation. This research concludes the direct influence of the extract and the size of the nanoparticles, and in that this factor is highly variable due to the dependence of its properties on their phytoconstituents and the territory. furthermore, a trend in the formation of spherically shape nanomaterials was identified. and finally, it is recognized that through the biogenic synthesis the formation of nanostructures was crystalline, obtaining a considerable level of purity in each nanoparticle considered.
The Influence of the Intergranular Superdisintegrant Performance on New Drotaverine Orodispersible Tablet Formulations

The main objective of this study consists in establishing the influence of the intergranular superdisintegrant on the specific properties of drotaverine hydrochloride fast-dissolving granules (DROT-FDGs) and orodispersible tablets (DROT-ODTs). The orodispersible tablets were obtained by the compression of the FDGs and excipient mixture with an eccentric tableting machine. To develop DROT-ODTs, two types of superdisintegrant excipients in different concentrations (water-soluble soy polysaccharides (SSP) (1%, 5%) and water-insoluble soy polysaccharides—Emcosoy® STS IP (EMCS) (1%, 3%, 5%)) were used, resulting in five formulations (D1–D5). The DROT-FDGs and the DROT-ODTs were subjected to pharmacotechnical and analytical evaluation. All the orodispersible tablets obtained respect the quality requirements in terms of friability (less than 1%), crushing strength (ranging between 52 N for D2 and 125.5 N for D3), and disintegration time (<180 s). The in vitro release of drotaverine from ODTs showed that all formulations presented amounts of active substance released greater than 85% at 10 min. The main objective, developing 30 mg DROT-ODTs for children aged between 6 and 12 years by incorporating the API in FDGs, was successfully achieved.
Ergonomic Evaluation of Workstation of University Administrative Staff in Rawalpindi and Islamabad

Background: Workstation ergonomic designs, if inappropriate, can lead to exposure to risk factors of work-related musculoskeletal disorders. The objective of this study was to evaluate workstation ergonomic risk factors of university administrative staff. Methods: A descriptive cross-sectional study was conducted on administrative staff workers in the universities of Rawalpindi and Islamabad from July 2021- June 2022. Nonprobability convenient sampling was employed to recruit a sample size of 351 university admin staff employees aged 20 to 60 years, both male and female, who work on computer for 6-8 hours. Data was collected through a self-structured demographic form and Rapid Office Strain Assessment (ROSA) tool. Data was entered and analyzed on SPSS v.21. The results were expressed as descriptive statistics and reported in averages. The qualitative variables were reported as frequencies and percentages. Results: The study comprised of 107 (30.5%) females and 244 (69.5%) males with a mean age of 34.80 ± 9.118 years. Results showed that the mean total ROSA score was 6.07 ±1.195. Categorizing the risk level, 242 (68.9%) fell in high risk and only 30 (8.5%) were classified in low-risk and those in the warning zone were 79 (22.5%). The highest at risk score was observed for keyboard and lowest for chair height of workstation. Total ROSA score was highest in administrative accounts department with a mean of 6.47±1.080. Conclusion: The university administrative staff were at considerably higher risk of developing work-related musculoskeletal disorders due to poor ergonomic computer workstations. The highest score was observed for keyboard placement, followed by back support. Moreover, individuals working in the administrative accounts department were at the highest ergonomic risk.
Case report: Magnetocardiography as a potential method of therapy monitoring in amyloidosis

Amyloidosis is characterized by a disorder of protein conformation and metabolism, resulting in deposits of insoluble fibrils in various organs causing functional disturbances. Amyloidosis can also affect the heart. Cardiac amyloidosis tends to have a poor prognostic outcome if diagnosed at a late stage. Therefore, early diagnosis and initiation of therapy as well as monitoring of treatment response are crucial to improve outcomes and to learn more about its pathophysiology and clinical course. We present an 83-year-old woman with cardiac transthyretin amyloidosis (ATTR) who was treated with tafamidis. The patient significantly improved 18 months after initiation of therapy with regards to exercise capacity and quality of life. In addition to standard diagnostic methods, we used magnetocardiography (MCG) to monitor potential treatment response by detecting changes in the magnetic field of the heart. MCG is a non-invasive method that detects the cardiac magnetic field generated by electrical currents in the heart with high sensitivity. We have recently shown that this magnetic field changes in various types of cardiomyopathies may be used as a non-invasive screening tool. We determined previously that an MCG vector ≥0.052 was the optimal threshold to detect cardiac amyloidosis. The patient's MCG was measured at various time points during therapy. At the time of diagnosis, the patient's MCG vector was 0.052. After starting therapy, the MCG vector increased to 0.090, but improved to 0.037 after 4 months of therapy. The MCG vector reached a value of 0.017 after 5 months of therapy with tafamidis, and then increased slightly after 27 months to a value of 0.027 (<0.052). Data from this case support our previous findings that MCG may be used to monitor treatment response non-invasively. Further research is needed to understand the unexpected changes in the MCG vector that were observed at the beginning of therapy and later in the course. Larger studies will be necessary to determine how these changes in the electromagnetic field of the heart are related to structural changes and how they affect clinical outcomes.
A taxonomic and nomenclatural revision of the historical brachiopod collection from the Lower Jurassic of Yakacik (Ankara, Turkey), housed in the Geological and Geophysical Institute of Hungary

In this paper the Early Jurassic brachiopods from Yakacik (Turkey), housed at the Geological and Geophysical Institute of Hungary, are examined in detail in the framework of a taxonomic and nomenclatural revision of the 197 specimens collected by R. MILLEKER in 1911–1912, and shortly described by VADÁSZ (1913a, b, 1918). This revision resulted in the identification of 27 brachiopod taxa. They represent 16 genera and 23 nominal species; these are systematically described and documented by photographs and partly by serial sections. The new brachiopod taxa introduced and illustrated by VADÁSZ (1913a, b): Rhynchonellina anatolica and Waldheimia anatolica are re-evaluated and their taxonomic positions are updated as Suessia ? anatolica (VADÁSZ, 1913) and Aulacothyris anatolica (VADÁSZ, 1913), respectively. The Early Jurassic (Pliensbachian) brachiopod fauna of Yakacik shows a transitional character between two major faunal provinces: besides 4 endemic and 4 cosmopolitan species, 6 species have NW European, and 9 species have Mediterranean faunal affinity.
Taking the developmental state seriously: Why South Korea outperformed neoliberal regulatory states in rapid coronavirus disease 2019 vaccinations and saving lives

Coronavirus disease 2019 claimed more than three million lives worldwide in 2020, giving national governments the most urgent task for 2021 to achieve high vaccination rates to save lives. The World Health Organization declared that “vaccines are the most critical tool to end the pandemic and save lives. ” In this context, South Korea (hereafter, Korea) achieved a remarkable milestone by outperforming the United Kingdom and the United States in vaccinations rate, where the world's earliest vaccination programs started. Thanks to its high vaccination rate, Korea recorded less than 100 deaths per million populations in 2021 compared to more than 1000 in the United Kingdom and the United States. Why Korea leaped ahead of the United Kingdom and the United States in rapid vaccinations that saved many lives? To answer this question, I first conceptualize contemporary Korea as a developmental state which retained its institutional capacity despite its transition from authoritarianism to liberal democracy, distinguishing it from the UK and the US's neoliberal regulatory states, where reforms hallowed out state capacity. I then advance two core claims. First, Korea surpassed the United Kingdom and the United States in vaccine rollout because of its developmental state-type goal-oriented autonomous policymaking and strong institutional capacity, manifested as Korea's central agency deployed a command and control vaccination program led by a coherent health bureaucracy. Second, the Korean state's strategic intervention in the market and its capacity to foster public–private partnerships to realize national goals boosted its vaccinations. Finally, the paper suggests how neoliberal regulatory states in the global north can learn lessons from the Korean experience in rebuilding state capacity to deal with the future global pandemic.