Miracle-dz/UniFAR-FTUs huggingface dataset:
Economic inequality in malnutrition: a global systematic review and meta-analysis

Objective To describe the evidence on global and regional economic inequality in malnutrition, and the associations between economic inequality and malnutrition. Methods We conducted a systematic review and meta-analysis. Between 1 November 2020 and 22 January 2021, we searched Medline, Embase, Global Health, Eldis, Web of Science and EBSCO Discovery Service. We contacted 39 experts and tracked citations. We included any study reporting a concentration index (CIX) relating economic status and nutritional status and any multilevel study reporting an association between economic inequality and nutritional status. Nutritional status was measured as stunting, wasting, anaemia, or overweight in children (<5 years), or underweight, overweight or obesity, or anaemia in adults (15–49 years). We had no study date or language restriction. Quality was assessed using the Appraisal Tool for Cross-Sectional Studies (AXIS tool). We mapped estimates and pooled them using multilevel random-effects meta-analyses. Results From 6185 results, 91 studies provided 426 CIX (>2.9 million people) and 47 associations (~3.9 million people). Stunting (CIX −0.15 (95% CI −0.19 to −0.11)) and wasting (−0.03 (95% CI −0.05 to −0.02)) are concentrated among poor households. Adult overweight and obesity is concentrated in wealthier households (0.08 (95% CI −0.00 to 0.17)), particularly in South Asia (0.26 (95% CI 0.19 to 0.34)), but not in Europe and Central Asia (−0.02 (95% CI −0.08 to 0.05)) or North America (−0.04 (95% CI −0.10 to 0.03)). We found no association between 0.1 increase in Gini coefficient and adult underweight (OR 1.03 (95% CI 0.94 to 1.12)) or overweight and obesity (0.92 (95% CI 0.80 to 1.05)). Conclusions There is good evidence that the prevalence of malnutrition varies by levels of absolute economic status. Undernutrition is concentrated in poor households, whereas concentration of overweight and obesity by economic status depends on region, and we lack information on economic inequalities in anaemia and child overweight. In contrast, links between malnutrition and relative economic status are less clear and should not be assumed; robust evidence on causal pathways is needed. PROSPERO registration number CRD42020201572.
Case Report: Erdafitinib-induced Central Serous Chorioretinopathy

SIGNIFICANCE Erdafitinib is the first fibroblast growth factor receptor inhibitor approved by the U.S. Food and Drug Administration in April 2019 for the treatment of locally advanced and unresectable or metastatic urothelial carcinoma. Central serous chorioretinopathy is a common ocular adverse effect requiring frequent monitoring with ophthalmic examination. PURPOSE This study aimed to increase awareness of erdafitinib-induced central serous chorioretinopathy, highlight erdafitinib dose management guidelines, and emphasize the importance of collaborating with oncologists to prevent adverse visual consequences. CASE REPORT An 80-year-old patient with an advanced urothelial cancer with fibroblast growth factor receptor mutations developed central serous chorioretinopathy when he was treated with daily 8 mg of erdafitinib. The erdafitinib-induced central serous chorioretinopathy resolved completely after the discontinuation of erdafitinib. He was then treated with daily 6 mg of erdafitinib and again developed central serous chorioretinopathy, which resolved completely upon discontinuation of the medication. The patient then decided to stop treatment with erdafitinib. CONCLUSIONS Erdafitinib, a potent tyrosine kinase receptor inhibitor of fibroblast growth factor receptors 1 to 4, demonstrates antitumor activity in advanced urothelial carcinoma with fibroblast growth factor receptor mutations with a response rate of approximately 40%. However, central serous chorioretinopathy develops in 25% of patients treated with a daily 8-mg dose of erdafitinib. Although most mild to moderate erdafitinib-induced central serous chorioretinopathies resolve with dose interruption or reduction, occasionally discontinuation of the medication is necessary. Therefore, careful coordination with oncologists is important to assess the impact of erdafitinib on vision, quality of life, and survival prognosis.
Obesity Duration, Severity, and Distribution Trajectories and Cardiovascular Disease Risk in the Atherosclerosis Risk in Communities Study

Background Research examining the role of obesity in cardiovascular disease (CVD) often fails to adequately consider heterogeneity in obesity severity, distribution, and duration. Methods and Results We here use multivariate latent class mixed models in the biracial Atherosclerosis Risk in Communities study (N=14 514; mean age=54 years; 55% female) to associate obesity subclasses (derived from body mass index, waist circumference, self‐reported weight at age 25, tricep skinfold, and calf circumference across up to four triennial visits) with total mortality, incident CVD, and CVD risk factors. We identified four obesity subclasses, summarized by their body mass index and waist circumference slope as decline (4.1%), stable/slow decline (67.8%), moderate increase (24.6%), and rapid increase (3.6%) subclasses. Compared with participants in the stable/slow decline subclass, the decline subclass was associated with elevated mortality (hazard ratio [HR] 1.45, 95% CI 1.31, 1.60, P<0.0001) and with heart failure (HR 1.41, 95% CI 1.22, 1.63, P<0.0001), stroke (HR 1.53, 95% CI 1.22, 1.92, P=0.0002), and coronary heart disease (HR 1.36, 95% CI 1.14, 1.63, P=0.0008), adjusting for baseline body mass index and CVD risk factor profile. The moderate increase latent class was not associated with any significant differences in CVD risk as compared to the stable/slow decline latent class and was associated with a lower overall risk of mortality (HR 0.85, 95% CI 0.80, 0.90, P<0.0001), despite higher body mass index at baseline. The rapid increase latent class was associated with a higher risk of heart failure versus the stable/slow decline latent class (HR 1.34, 95% CI 1.10, 1.62, P=0.004). Conclusions Consideration of heterogeneity and longitudinal changes in obesity measures is needed in clinical care for a more precision‐oriented view of CVD risk.
Mosaicism in clinical genetics

Genetic mosaicism is the state in which there are two or more different sets of cells in a single individual because of one or more postzygotic mutations, and its importance in clinical genetics has long been recognized (Hall, Am J Hum Genet 43: 355 [1988]). In this Perspective, a paper in this special issue on mosaicism from Cook et al. (Cold Spring Harb Mol Case Studies 7: a006125 [2021]) is discussed.
TEHD Lubrication of Mechanical Face Seals in Stable Tracking Mode: Part 1—Numerical Model and Experiments

After a short presentation of state-of-the-art experimental studies on the thermal behavior of non-contacting face seals, the literature about numerical models for thermal effects is investigated. Next, the geometry, kinematics and dynamics of a steady state three-dimensional model are developed. Simplified Navier-Stokes equations, a generalized Reynolds equation and an energy equation with proper boundary conditions are established for flow regimes, varying from laminar to turbulent. The numerical computer code for solving the governing equations is presented and representative results are shown. It is demonstrated that face distortions strongly modify the seals' thermal behavior. An original test rig has been developed in order to ensure full fluid film conditions. This apparatus and the experimental procedure are described. The ability of the numerical model to simulate real configurations is also illustrated. Theoretical and experimental results are in good agreement. Yet an improved model of heat transfer on boundaries is still needed.
Endothelial cell–derived exosomal circHIPK3 promotes the proliferation of vascular smooth muscle cells induced by high glucose via the miR-106a-5p/Foxo1/Vcam1 pathway

The abnormal proliferation of vascular smooth muscle cells (VSMCs) plays an important role in the development and progression of diabetic vascular complications. In high-glucose (HG) conditions, endothelial cells (ECs) act as the first barrier to damaging stimuli and trigger a multi-response, including EC and VSMC crosstalk. However, the crosstalk pathways between ECs and VSMCs under HG conditions remain unclear. This study aimed to explore the roles and underlying mechanism of exosomes derived from ECs in the crosstalk between ECs and VSMCs. Our results showed that mouse aortic endothelial cell (MAEC)–secreted exosomes could promote the proliferation and inhibit the apoptosis of VSMCs induced by HG. Furthermore, we isolated the exosomes secreted by MAECs and found that exosomes derived from MAECs that were exposed to HG could transfer circHIPK3, which is enriched in MAEC-derived exosomes, to VSMCs. Exosomal circHIPK3 promoted the proliferation and inhibited the apoptosis of VSMCs. circHIPK3 sponged miR-106a-5p to relieve its repression of forkhead box O1 (Foxo1) expression. The increased expression of Foxo1 acted as a transcription factor to promote Vcam1 expression, thus facilitating the uptake of MAEC-derived exosomes by VSMCs. The results of this study suggested that exosomal circHIPK3 derived from MAECs promotes the proliferation of VSMCs induced by HG via the miR-106a-5p/Foxo1/Vcam1 pathway.
Angiotensin‐Converting Enzyme Inhibitors, Angiotensin II Receptor Blockers, and Outcomes in Patients Hospitalized for COVID‐19

Background Use of angiotensin‐converting enzyme inhibitors and angiotensin receptor blockers (ACEi/ARB) is thought to affect COVID‐19 through modulating levels of angiotensin‐converting enzyme 2, the cell entry receptor for SARS‐CoV2. We sought to assess the association between ACEi/ARB, biomarkers of inflammation, and outcomes in patients hospitalized for COVID‐19. Methods and Results We leveraged the ISIC (International Study of Inflammation in COVID‐19), identified patients admitted for symptomatic COVID‐19 between February 1, 2020 and June 1, 2021 for COVID‐19, and examined the association between in‐hospital ACEi/ARB use and all‐cause death, need for ventilation, and need for dialysis. We estimated the causal effect of ACEi/ARB on the composite outcomes using marginal structural models accounting for serial blood pressure and serum creatinine measures. Of 2044 patients in ISIC, 1686 patients met inclusion criteria, of whom 398 (23.6%) patients who were previously on ACEi/ARB received at least 1 dose during their hospitalization for COVID‐19. There were 215 deaths, 407 patients requiring mechanical ventilation, and 124 patients who required dialysis during their hospitalization. Prior ACEi/ARB use was associated with lower levels of soluble urokinase plasminogen activator receptor and C‐reactive protein. In multivariable analysis, in‐hospital ACEi/ARB use was associated with a lower risk of the composite outcome of in‐hospital death, mechanical ventilation, or dialysis (adjusted hazard ratio 0.49, 95% CI [0.36–0.65]). Conclusions In patients hospitalized for COVID‐19, ACEi/ARB use was associated with lower levels of inflammation and lower risk of in‐hospital outcomes. Clinical trials will define the role of ACEi/ARB in the treatment of COVID‐19. Registration URL: https://www.clinicaltrials. gov; Unique identifier: NCT04818866.
Simple scale models for daylighting design: Analysis of sources of error in illuminance predictiont

This paper reports on the findings and implications of a study of the performance of small-scale physical lighting models. It seeks to clarify the primary causes of divergence between model and real building performance and to discuss the main factors involved in achieving accurate physical representations of buildings. A brief account of a case study is given in which an existing museum building was modelled. The methodology adopted is described and an analysis of the model's divergent performance from that of the building is made. This is followed by an examination of the core issues in scale modelling for accurate daylight prediction. The latter focuses on sources of error in the model's representation of dimensions and photometric properties. Drawing on examples from the case study it is suggested that the size of such errors may account for the apparently persistent overestimation of illuminance levels by lighting models. Proposals are suggested for dealing with error ranges in small-scale model performance.
Vector Control of Faulty Three-Phase Induction Motor with an Adaptive Sliding Mode Control

This paper presents an adaptive sliding mode control with an adaptive switching gain in order to vector control of Three-Phase Induction Motor (TPIM) based on Rotor Flux Oriented Control (RFOC) method under open-phase fault (faulty TPIM). This method can be utilized to control of IMs in some critical applications which require fault-tolerant scheme. To confirm the good performance of the proposed method, simulation results have been presented. The Simulation results confirm a completely satisfactory effectiveness of the proposed method.
Electric grid stability and the design of sustainable energy systems

Today, in most countries, electricity is produced either on hydropower or on large steam turbines on the basis of fossil fuels or nuclear power. Electricity from distributed generation constitutes only small amounts. Until now, the task of balancing supply and demand and the task of securing frequency and voltage on the grid has been left solely to large production units. Meanwhile, the implementation of cleaner technologies, such as renewable energy, combined heat and power production and energy conservation, is necessary for future sustainable energy systems. Consequently, such distributed production units sooner or later need to contribute to the task of securing a balance between electricity production and consumer demands. This paper presents technical designs of potential future flexible energy systems, which will be able both to balance production and demand and to secure voltage and frequency requirements on the grid.
Underascertainment of COVID-19 cases among first responders: a seroepidemiological study

Abstract Background Providing frontline support places first responders at a high risk for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Aims This study was aimed to determine the anti-SARS-CoV-2 seroprevalence in a cohort of first responders (i.e. firefighters/paramedics), to detect the underascertainment rate and to assess risk factors associated with seropositivity. Methods We conducted a serological survey among 745 first responders in Germany during 27 November and 4 December 2020 to determine the anti-SARS-CoV-2 seroprevalence using Elecsys® Anti-SARS-CoV-2 immunoassay (Roche Diagnostics, Mannheim, Germany). As part of the examination, participants were asked to provide information on coronavirus disease 2019 (COVID-19)-like-symptoms, information on sociodemographic characteristics and workplace risk factors for a SARS-CoV-2 infection and any prior COVID-19 infection. Descriptive statistics and logistic regression analysis were performed and seroprevalence estimates were adjusted for test sensitivity and specificity. Results The test-adjusted seroprevalence was 4% (95% CI 3.1–6.2) and the underascertainment rate was 2.3. Of those tested SARS-CoV-2 antibody positive, 41% were aware that they had been infected in the past. Seropositivity was elevated among paramedics who worked in the emergency rescue team providing first level of pre-hospital emergency care (6% [95% CI 3.4–8.6]) and those directly exposed to a COVID-19 case (5% [95% CI 3.5–8.1]). Overall, the seroprevalence and the underascertainment rate were higher among first responders than among the general population. Conclusions The high seroprevalence and underascertainment rate highlight the need to mitigate potential transmission within and between first responders and patients. Workplace control measures such as increased and regular COVID-19-testing and the prompt vaccination of all personnel are necessary.
Inhibin subunit beta A promotes cell proliferation and metastasis of breast cancer through Wnt/β-catenin signaling pathway

ABSTRACT Emerging evidence has demonstrated that inhibin subunit beta A (INHBA) is dysregulated and plays a critical role in various cancers. With the development of sequencing technology, studies have discovered that INHBA is overexpressed in breast cancer tissues. However, the biological roles of INHBA in breast cancer are still far to clear. In the present study, we analyzed the INHBA expression in the Cancer Genome Atlas (TCGA) database. Quantitative real-time polymerase chain reaction (qRT-PCR) was conducted to assess the expression of INHBA in breast cancer cell lines. Cell proliferation, invasion and epithelial–mesenchymal transition (EMT) were determined by using CCK-8, EdU, Transwell and western blot assays. The result showed that INHBA was highly expressed in breast cancer cell lines. Functional analysis revealed that silence or elevation of INHBA inhibited or promoted the proliferation, migration, invasion and EMT and Wnt/β-catenin signaling pathway-related markers of MCF-7 cells. Mechanically, blocking of Wnt/β-catenin pathway by XAV939 reversed the promotion effect of INHBA overexpression on breast cancer cells’ proliferation, migration and invasion. Our findings emphasized that INHBA may act as an oncogene via activating the Wnt/β-catenin pathway, which may provide a potential therapeutic target for the treatment of breast cancer. GRPAHICAL ABSTRACT
Cost Benefit Analysis of Anti-Strip Additives in Hot Mix Asphalt with Various Aggregates

This report documents research on moisture sensitivity testing of hot-mix asphalt (HMA) mixes in Pennsylvania and the associated use of antistrip. The primary objective of the research was to evaluate and compare benefit/cost ratios of mandatory use of antistrip, and of antistrip usage conditional on the results of moisture resistance testing, based upon life cycle cost analyses. A secondary objective was to evaluate a unique version of the modified Lottman procedure used in Pennsylvania between 2003 and October 2014, which involved a relatively low level of saturation in specimen conditioning. This procedure (low-saturation method) typically results in saturation between about 30 % and 67 %, as compared to the 70 to 80 % required in the test version used by Pennsylvania prior to 2003 and after October 2014 (high-saturation method). It was found that the low-saturation method passed all HMA mixes, even those with a documented history of high susceptibility to moisture damage. This procedure therefore had a benefit/cost ratio of zero. For the high-saturation method, it was found that both antistrip usage dependent on the results of testing and mandatory usage for all mixes had benefit/cost ratios that were greater than one and in general much greater than one. The benefit/cost ratios for mandatory antistrip usage were greater than those for conditional usage, because of the high cost associated with the failure of moisture resistance testing to identify all moisture susceptible mixes.
Hybrid PPC methodology using multi-step correction and implementation for the sub-100-nm node

As semiconductor devices are scaled down to the sub-100nm node, the fine control of ACLV (across-chip line-width variation) to improve the performance of chips and the expansion of the process window to enhance yield are required. One of the techniques reducing ACLV is MPPC (model-based process proximity correction). However, it increases pattern complexity and does not guarantee enough process windows. Therefore, we propose a HPPC (hybrid PPC) methodology combining RPPC (rule-based PPC) and MPPC, which correct the gate on active by MPPC for device performance and the field gate by RPPC for process window. In addition, we optimize SRAF (sub-resolution assist feature) design to improve process windows further at the full chip level and apply the multi-step correction, which corrects optical and etch proximity effects separately to minimize ACLV. As the result of the application to the 90nm logic gate, we achieve over 0.3um DOF (depth of focus) and the line-width variation within ±5% of the target CD (critical dimension).
Effective CD4 T cell priming requires repertoire scanning by CD301b+ migratory cDC2 cells upon lymph node entry

Description CD301b+ migratory cDC2 cells temporarily retain polyclonal CD4 T cells during priming to scan their antigen specificity. Antigen display window The detection of CD4 T cells that are specific to cognate antigens is a critical first step of the adaptive immune response. CD4 T cells home to lymph nodes (LNs) and are briefly retained here for detection and priming of cognate clones. Tatsumi et al. now describe a role for CD301b+ migratory type 2 conventional dendritic cells (cDC2) that enter LNs and localize near high endothelial venules to support cognate clone stimulation. CD301b+ cDC2 retain naïve polyclonal CD4 T cells after LN entry in an MHCII-dependent but antigen-independent manner and provide stimuli to cognate clones. These interactions serve as an antigen display window for CD4 T cells to scan their antigen specificity and initiate an antigen-specific adaptive immune response. During the initiation of adaptive immune responses, millions of lymphocytes must be scanned to find the few cognate clones. The activation mechanisms of CD4 T cells have been extensively studied, but the cellular mechanisms that drive selection of cognate clones are not completely understood. Here, we show that recently homed naïve polyclonal CD4 T cells are temporarily retained before leaving the lymph node. This stop-and-go traffic of CD4 T cells provides an adequate time window for efficient scanning and timely priming of antigen-specific cognate clones. CD301b+ DCs, a major subset of migratory cDC2 cells, localize to the areas around high endothelial venules, where they retain incoming polyclonal CD4 T cells through MHCII-dependent but antigen-independent mechanisms, while concurrently providing cognate stimuli for priming. These results indicate that CD301b+ DCs function as an immunological “display window” for CD4 T cells to efficiently scan their antigen specificity.
The genus Eurytromma from Sri Lanka: the homology of penial macrosetae in Podoctidae matches the gonyleptoid AE11 pattern (Opiliones: Laniatores: Epedanoidea)

Abstract. A description of the pattern of structure and organization of the penial macrosetae was recently put forward for Gonyleptoidea Sundevall, 1833 and demonstrated to occur also in other families of Grassatores Kury, 2002, such as Assamiidae Sørensen, 1884, Epedanidae Sørensen, 1886 and Pyramidopidae Sharma, Prieto & Giribet, 2011. This set of homology hypotheses is herein called AE11 pattern. In this work, the monotypic Sri Lankan genus Eurytromma Roewer, 1949 of the family Podoctidae Roewer, 1912 (which is currently assigned to the Epedanoidea in the Grassatores) is studied. Male genitalia of Eurytromma are described for the first time and the first attempt is made to reconcile the chaetotaxy of ventral plate of podoctid species with the AE11 pattern. The podoctid genera Hoplodino Roewer, 1915, Strandibalonius Roewer, 1912 and Santobius Roewer, 1949 are also exemplified here; their set of macrosetae is described and the AE11 pattern is demonstrated to occur in all of them. Therefore, AE11 is more phylogenetically widespread in the Grassatores than previously thought. Eurytromma pictulum (Pocock, 1903) from Sri Lanka is redescribed. It is characterized by the presence of a meso-frontal stridulatory saw of denticles on the cheliceral hand and extreme reduction of mesotergal sutures. A further refinement is made on the current terminology system of cheliceral dentition of Podoctidae.