Miracle-dz/UniFAR-FTUs huggingface dataset:
Biomechanical changes in the gastrocnemius medius–Achilles tendon complex in people with hypermobility spectrum disorders: A cross-sectional compression sonoelastography study

Objective This study aimed to assess the biomechanical impact of Hypermobility Spectrum Disorders (HSD) on the elasticity of the gastrocnemius medius-Achilles tendon (GM-AT) complex. Methods Using a cross-sectional design, the GM-AT complex elasticity was compared using sonoelastography (SEG) in an HSD group and healthy controls during rest and maximal isometric plantar flexion contraction. Results The HSD group comprised 28 patients (26 women); mean ± SD age 28.7 ± 8.4 years, compared to 28 controls (26 women); 31.5 ± 8.7 years. During rest, greater elasticity was identified in HSD relative to controls at the GM-AT musculotendinous junction (strain ratio 2.05 ± 1.31 vs. 1.48 ± 0.49), mid-AT (3.60 ± 1.97 vs. 2.66 ± 1.00), and distal AT (4.57 ± 2.69 vs. 3.22 ± 1.94) (all p < 0.05). During contraction, no significant differences were found between groups at the GM-AT musculotendinous junction (3.40 ± 2.16 vs. 2.62 ± 1.07), mid AT (10.75 ± 5.29 vs. 8.49 ± 3.53), or distal AT (8.55 ± 5.39 vs. 8.83 ± 3.51) (all p > 0.05). No significant differences were found between groups in the GM strain ratio during rest (4.05 ± 1.43 vs. 3.62 ± 0.78), or contraction (4.23 ± 1.29 vs. 4.19 ± 1.31). Exploratory Receiver Operator Characteristics curve analysis suggested low sensitivity and specificity of the strain ratio for the diagnosis of HSD. Conclusion People with HSD have greater GM-AT complex elasticity. Although statistically significant group differences were identified, further research is required to establish the diagnostic, clinical, and research utility of strain ratio measurements.
THE BARIUM STARS.

The barium stars are Population I G-K giants that have enhanced abundances of carbon and s-process elements, and are probably related in their peculiarities to several other carbon enhanced red-giant types such as CH, R, N, and S stars. Since the abundance anomalies in the barium stars are likely the result of mixing of processed material from deep within a stellar interior, and since they are numerous with many bright examples suitable for detailed observations, these stars provide very valuable information on nucleosynthesis, and the advanced stages of stellar evolution. A clue to the origin of the anomalous abundances in the barium stars is the recent discovery that they are likely all members of binary systems.
Whole-lesion histogram analysis of multiple diffusion metrics for differentiating lung cancer from inflammatory lesions

Background Whole-lesion histogram analysis can provide comprehensive assessment of tissues by calculating additional quantitative metrics such as skewness and kurtosis; however, few studies have evaluated its value in the differential diagnosis of lung lesions. Purpose To compare the diagnostic performance of conventional diffusion-weighted imaging (DWI), intravoxel incoherent motion (IVIM) magnetic resonance imaging (MRI) and diffusion kurtosis imaging (DKI) in differentiating lung cancer from focal inflammatory lesions, based on whole-lesion volume histogram analysis. Methods Fifty-nine patients with solitary pulmonary lesions underwent multiple b-values DWIs, which were then postprocessed using mono-exponential, bi-exponential and DKI models. Histogram parameters of the apparent diffusion coefficient (ADC), true diffusivity (D), pseudo-diffusion coefficient (D*), and perfusion fraction (f), apparent diffusional kurtosis (Kapp) and kurtosis-corrected diffusion coefficient (Dapp) were calculated and compared between the lung cancer and inflammatory lesion groups. Receiver operating characteristic (ROC) curves were constructed to evaluate the diagnostic performance. Results The ADCmean, ADCmedian, D mean and D median values of lung cancer were significantly lower than those of inflammatory lesions, while the ADCskewness, Kapp mean, Kapp median, Kapp SD, Kapp kurtosis and Dapp skewness values of lung cancer were significantly higher than those of inflammatory lesions (all p < 0.05). ADCskewness (p = 0.019) and D median (p = 0.031) were identified as independent predictors of lung cancer. D median showed the best performance for differentiating lung cancer from inflammatory lesions, with an area under the ROC curve of 0.777. Using a D median of 1.091 × 10-3 mm2/s as the optimal cut-off value, the sensitivity, specificity, positive predictive value and negative predictive value were 69.23%, 85.00%, 90.00% and 58.62%, respectively. Conclusions Whole-lesion histogram analysis of DWI, IVIM and DKI parameters is a promising approach for differentiating lung cancer from inflammatory lesions, and D median shows the best performance in the differential diagnosis of solitary pulmonary lesions.
Amplitude modulations of seasonal variability in the Karimata Strait throughflow

The Karimata Strait (KS) throughflow between the South China Sea (SCS) and Java Sea plays an essential role in heat and freshwater budget in the SCS and dual roles in strengthening/reducing the primary Indonesian throughflow (ITF) in the Makassar Strait. A sustained long-term monitoring of the ITF is logistically challenging and expensive; therefore, proxies are needed. Here, we use a combination of in situ measurement of the KS throughflow and satellite-derived sea surface height (SSH) and sea surface wind (SSW) to determine the interannual and decadal modulations in seasonal amplitude of the KS throughflow associated with El Niño-Southern Oscillation (ENSO), Indian Ocean dipole (IOD), Pacific Decadal Oscillation (PDO). Linear regression, correlation, harmonic and power spectrum analyses are used. The results manifest that there are significant interannual to decadal modulations in the seasonal amplitude of the KS throughflow. The modulations of the seasonal amplitude in the volume and heat transports range 1.36-1.92 Sv (1 Sv = 106 m3 s-1) and 126.41-173.36 TW (1 TW = 1012 W), respectively, with a significant cycle of ~9 years. From 1994 to 2020, the seasonal amplitude of volume transport through the KS shows an increasing trend of 37.75 ± 15.69 mSv decade-1 (1 mSv = 103 m3 s-1). The seasonal amplitude of the heat transport also increases, at a rate of 4.78 ± 1.52 TW decade-1. The KS volume transport is positively correlated with PDO and ENSO indices (r2 = 0.69 and r2 = 0.58), with a lag of 12 and 10 months, respectively. The results of composite analysis suggest that the interannual variability of the KS transport is related to the interannual anomalies of the SSH gradient and the local SSW fields in boreal winter.
Parentification, distress, and relationship with parents as factors shaping the relationship between adult siblings and their brother/sister with disabilities

According to parentification theory, when the siblings of a brother/sister with disabilities assume parent-like duties, this role reversal is known as sibling-focused parentification. It has a significant impact on these siblings’ distress and the quality of their family relationships; 605 Italian adult siblings (19–26 years) of people with disabilities completed the online survey. Measures of siblings’ parentification, distress, quality of family relationships, social support, and perceived benefits of parentification were used. The hypothesized model aims to test, on the target sample, the distress and the quality of the relationship with parents as mediators on the interplay between the siblings’ parentification and their sibling relationship. Additionally, social support and perceived benefits of parentification as protective factors were considered. Results showed that the distress and the low quality of the relationship with parents negatively affected the interplay between the siblings’ parentification and the relationship with their own brother/sister with disabilities. Social support and the perceived benefits of parentification decreased the siblings’ distress levels; the perceived benefits of parentification served as a protective factor for the quality of the relationship with parents. Current findings extend the knowledge regarding the risk and protective factors of the siblings’ mental health when disability occurs in the family. Additionally, they inform family-based intervention programs, which should involve the whole family system for reducing distress and improving the wellbeing of siblings without disabilities.
Altered task induced functional brain networks and small-world properties in autism

Introduction Facial emotion recognition (FER) requires the integration of multi-dimensional information across various brain regions. Autistic individuals commonly experience difficulties in FER, a phenomenon often attributed to differences in brain connectivity. The nature of task-induced functional brain networks could provide insight into the neuromechanisms underlying FER difficulties in autism, however, to date, these mechanisms remain poorly understood. Methods In this study, the task induced functional brain networks of 19 autistic and 19 gender, age, and IQ matched non-autistic individuals were examined during a complex FER task. Electroencephalogram (EEG)-based functional brain networks were examined, including the investigation of differences in the time-varying whole-brain functional networks and the exploration of the task induced small-world properties. Results The results showed statistically significant differences in the task-induced functional networks between autistic and non-autistic adults. Autistic adults compared to non-autistic adults showed a significant shift in the connectivity-based FER processing from the lower to the higher EEG frequency bands. Discussion These findings may provide evidence at a neural level for the notion that autistic individuals have a preference for bottom-up lower-level processing, or alterations in top-down global processing, potentially contributing to the FER difficulties observed in this population. Results also suggest that functional brain networks in autism show significantly altered task-induced whole-brain small-world properties as compared to non-autistic individuals during complex FER. This study motivates further investigation of the underlying networks-basis of altered emotion processing in autism.
Global luminescent oil-film skin-friction meter

This paper describes a global luminescent oil-film skin-friction meter that is particularly useful in global skinfriction diagnostics for complex flows. This method is developed based on the relationship between the oil-film thickness and luminescent intensity of an oil film doped with luminescent molecules. The projected thin oil-film equation is given in the image plane, which relates skin friction with the normalized luminescent intensity. A variational formulation with a smoothness constraint on skin friction is given, and the corresponding Euler– Langrage equations are solved to obtain a snapshot solution for a relative skin-friction field. Successive snapshot solutions are superposed to reconstruct a complete relative skin-friction field, and the corresponding absolute field can be further determined by in situ calibration. This method is examined through numerical simulation and experiments.
Psychological support and strategies for raising motivation in fresh students

The goal of this study was to investigate the of fear of starting university training, determine its general characteristics, and test how providing psychological and motivational support for university enrollees may influence the elimination of this type of fear. The study used a random sample of 536 individuals, 268 participants each from one university in the Russian Federation and one from China, who were also randomly selected. Approximately equivalent experimental and control groups (134 people) were formed. The main experiment was conducted simultaneously for Chinese and Russian groups of participants under the same conditions. The modified Kessler psychological distress scale (K10) was used to measure fear of starting training 10 days before training and 2 days after. The experimental group received a special 7-step training to overcome fear and prepare for learning; results between groups and results before and after the start of training were compared using Student’s t-test. Test scores for each participant were tested using Pearson’s correlation to establish an association with the intervention for the majority of participants. In sum, the results of the carried out testing demonstrate a marked reduction in fear and stress after the start of training for both groups of both universities. Those students who have already experienced support show lower levels of fear of starting a course than those who have not received any help. The results of this study can be used to prepare university applicants for their future studies.
The adjuvant effect of bacterium-like particles depends on the route of administration

Direct administration of vaccines to mucosal surfaces, such as via oral or nasal vaccination, represents an attractive alternative, or complement, to current parenteral vaccination because it has a potential to induce antigen-specific immunity both at mucosal and systemic tissues. Although bacterium-like particles (BLPs), peptidoglycan structures derived from lactic acid bacteria, have been investigated as a novel adjuvant for oral or nasal vaccines, it remains unclear whether the administration routes differ the adjuvant effect of BLPs. Here, we showed that the adjuvant effect of BLPs from Lactococcus lactis NZ9000 is greater with the nasal administration than with the oral administration. We conjugated BLPs with Tir, a virulence factor of Citrobacter rodentium, as a model adjuvant-antigen complex, and found that nasal, but not oral, immunization of mice with BLP-Tir induced robust antigen-specific IgA responses at the respiratory and intestinal mucosa, IgG2b-skewed systemic responses, and Th17 cellular responses. As one of the underlying mechanisms, we demonstrated that the nasal administration has a greater delivery efficiency (~1,000-fold) of the BLPs-conjugated antigens to mucosal-associated lymphoid tissues than the oral administration. Furthermore, the nasal, but not oral, administration of BLP-Tir elicited robust innate immune responses that were characterized by the expression of various pro-inflammatory cytokines and chemokines in the mucosal-associated lymphoid tissues. Considering these findings together, we anticipate that BLPs can be an attractive novel adjuvant for nasal vaccines targeting not only respiratory but also gastrointestinal infectious diseases.
Treadmill training of rats after sciatic nerve graft does not alter accuracy of muscle reinnervation

Background and purpose After peripheral nerve lesions, surgical reconstruction facilitates axonal regeneration and motor reinnervation. However, functional recovery is impaired by aberrant reinnervation. Materials and methods We tested whether training therapy by treadmill exercise (9 × 250 m/week) before (run–idle), after (idle–run), or both before and after (run–run) sciatic nerve graft improves the accuracy of reinnervation in rats. Female Lewis rats (LEW/SsNHsd) were either trained for 12 weeks (run) or not trained (kept under control conditions, idle). The right sciatic nerves were then excised and reconstructed with 5 mm of a congenic allograft. One week later, training started in the run–run and idle–run groups for another 12 weeks. No further training was conducted in the run–idle and idle–idle groups. Reinnervation was measured using the following parameters: counting of retrogradely labeled motoneurons, walking track analysis, and compound muscle action potential (CMAP) recordings. Results In intact rats, the common fibular (peroneal) and the soleus nerve received axons from 549 ± 83 motoneurons. In the run–idle group, 94% of these motoneurons had regenerated 13 weeks after the nerve graft. In the idle–run group, 81% of the normal number of motoneurons had regenerated into the denervated musculature and 87% in both run–run and idle–idle groups. Despite reinnervation, functional outcome was poor: walking tracks indicated no functional improvement of motion in any group. However, in the operated hindlimb of run–idle rats, the CMAP of the soleus muscle reached 11.9 mV (normal 16.3 mV), yet only 6.3–8.1 mV in the other groups. Conclusion Treadmill training neither altered the accuracy of reinnervation nor the functional recovery, and pre-operative training (run–idle) led to a higher motor unit activation after regeneration.
United States Gulf of Mexico Waters provide important nursery habitat for Mexico’s Green turtle nesting populations

Resolving natal populations for juvenile green turtles is challenging given their potential for extensive dispersal during the oceanic stage and ontogenetic shifts among nursery habitats. Mitochondrial DNA markers have elucidated patterns of connectivity between green turtle nesting populations (rookeries) and juvenile foraging aggregations. However, missing rookery baseline data and haplotype sharing among populations have often impeded inferences, including estimating origins of Gulf of Mexico juveniles. Here, we assessed genetic structure among seven foraging aggregations spanning southern Texas (TX) to southwestern Florida (SWFL), including Port Fourchon, Louisiana (LA); a surface-pelagic aggregation (SP) offshore of Louisiana and Florida; Santa Rosa Island, Florida (SRI); St. Joseph Bay, Florida (SJB); and the Big Bend region, Florida (BB). We estimated source contributions to aggregations with novel genetic data (excluding SP and BB) using a Bayesian many-to-one mixed stock analysis (MSA) approach. Haplotype frequencies for western (TX, LA, SP, SRI) and eastern (SJB, BB, SWFL) aggregations were significantly differentiated. The largest shift in haplotype frequencies between proximal nursery sites occurred between SRI and SJB, separated by only 150 km, highlighting the lack of a geographic yardstick for predicting genetic structure. In contrast to previous MSA results, there was no signal of Florida juveniles at any foraging site. Mexican contributions dominated in all aggregations, with strong connectivity between western Bay of Campeche (Tamaulipas/Veracruz) rookeries and western foraging aggregations. MSA indicated more diverse Mexican origins for eastern aggregations, with larger inputs from the eastern Bay of Campeche (Campeche/Yucatán), Campeche Bank, and Quintana Roo rookeries. These results demonstrate the significance of the Gulf of Mexico coast and offshore waters of the United States as important nursery habitat for green turtles of Mexican origin and highlight the need for international coordination for management of these populations.
Cinnamon and cognitive function: a systematic review of preclinical and clinical studies

ABSTRACT Cinnamon is the inner bark of trees named Cinnamomum. Studies have shown that cinnamon and its bioactive compounds can influence brain function and affect behavioral characteristics. This study aimed to systematically review studies about the relationship between cinnamon and its key components in memory and learning. Two thousand six hundred five studies were collected from different databases (PubMed, Scopus, Google Scholar, and Web of Science) in September 2021 and went under investigation for eligibility. As a result, 40 studies met our criteria and were included in this systematic review. Among the included studies, 33 were In vivo studies, five were In vitro, and two clinical studies were also accomplished. The main outcome of most studies (n = 40) proved that cinnamon significantly improves cognitive function (memory and learning). In vivo studies showed that using cinnamon or its components, such as eugenol, cinnamaldehyde, and cinnamic acid, could positively alter cognitive function. In vitro studies also showed that adding cinnamon or cinnamaldehyde to a cell medium can reduce tau aggregation, Amyloid β and increase cell viability. For clinical studies, one study showed positive effects, and another reported no changes in cognitive function. Most studies reported that cinnamon might be useful for preventing and reducing cognitive function impairment. It can be used as an adjuvant in the treatment of related diseases. However, more studies need to be done on this subject.
Batchelor versus Stewartson flow structures in a rotor-stator cavity with throughflow

The present work considers the turbulent flow inside a high-speed rotor-stator cavity with or without superimposed throughflow. New extensive measurements made at IRPHE by a two-component laser Doppler anemometer technique and by pressure transducers are compared to numerical predictions based on one-point statistical modeling using a low-Reynolds-number second-order full stress transport closure (Reynolds stress model). The advanced second-order model provides good predictions for the mean flow as well as for the turbulent field and so is the adequate level of closure to describe such complex flows. A better insight into the dynamics of such flows is also gained from this study. Indeed the transition between a Batchelor type of flow with two boundary layers separated by a central rotating core and a Stewartson type of flow with only one boundary layer on the rotating disk is characterized in the (r*,Ro) plane, where r* is the dimensionless radial location and Ro a modified Rossby number. The 5∕7 power-la.
An integrated microbiome project for charactering microbial diversity in classroom based on virtual simulation experiments

Microbiome study requires both molecular techniques and bioinformatics skills, which are challenging for biologists to participate in this growing field. To introduce microbiome concepts and skills to students, a 6‐week wet‐lab and bioinformatics course for undergraduates was implemented through the project‐based learning (PBL) approach. In the saliva microbiome project, students collected their saliva samples, performed DNA extraction and PCR amplification, followed by metagenomic analysis to compare the diversity and abundances of microbes among samples. First, students are required to practice molecular techniques and bioinformatics analysis skills in a virtual simulation lab. To our knowledge, our study is the first one to incorporate a virtual lab into microbiome experience. Then, students applied their recently acquired skills to produce and analyze their own 16S amplicon sequencing data and reported their results via a scientific report. The student learning outcomes show that the Virtual lab can improve students' laboratory techniques and research capabilities. Moreover, a simple pipeline to analyze 16S rRNA gene amplicon sequencing data is introduced in a step‐by‐step manner that helps students to develop analysis skills. This project can be modified as either a virtual course or a module within another course such as microbiology, molecular biology, and bioinformatics. Our study provides evidence on the positive impact of virtual labs on learning outcomes in undergraduate science education.
On the Role of Low-Mass Asymptotic Giant Branch Stars in Producing a Solar System Distribution of s-Process Isotopes

The production of s-isotopes due to the operation of the reaction C-13(alpha, n)O-16 in low-mass stars during asymptotic giant branch phases is investigated. The time evolution of the thermal pulses, the temperature, and the density stratification within the convective shells is followed in detail, taking into account the effect of the neutron recycling by C-12. The resulting average neutron density reaches a maximum of about 5 x to the 9th/cu cm and then decreases smoothly. Strong overabundances for all s-isotopes with A larger than 80 are obtained in a solar system distribution. The process appears suitable for reproducing many observed details concerning isotopic ratios. Contrary to previous estimates, an anomalous overproduction of Zr-96 is not obtained. 33 references.