Miracle-dz/UniFAR-FTUs huggingface dataset:
NG2 Molecule Expression in Acute Lymphoblastic Leukemia B Cells: A Flow-Cytometric Marker for the Rapid Identification of KMT2A Gene Rearrangements

Background B-lineage acute lymphoblastic leukemias (B-ALL) harboring rearrangements of the histone lysine [K]-Methyltransferase 2A (KMT2A) gene on chromosome 11q23 (KMT2A-r) represent a category with dismal prognosis. The prompt identification of these cases represents an urgent clinical need. Considering the correlation between rat neuron glial-antigen 2 (NG2) chondroitin-sulfate-proteoglycan molecule expression and KMT2A-r, we aimed to identify an optimized cytofluorimetric diagnostic panel to predict the presence of KMT2A-r. Materials and Methods We evaluated 88 NG2+ B-ALL cases identified with an NG2 positivity threshold >10% from a cohort of 1382 newly diagnosed B-ALLs referred to the Division of Hematology of ‘Sapienza’ University of Rome. Results Eighty-five of 88 (96.6%) NG2+ B-ALLs harbored KMT2A-r and were mainly pro-B ALL (77/85; 91%). Only 2 B-ALLs with KMT2A-r showed NG2 expression below 10%, probably due to the steroid therapy administered prior to cytofluorimetric analysis. Compared to KMT2A-r–cases, KMT2A r+ B-ALLs showed a higher blast percentage, significantly higher mean fluorescence intensity (MFI) of CD45, CD38, and CD58, and significantly lower MFI of CD34, CD22, TdT, and CD123. The study confirmed differences in CD45, CD34, CD22, and TdT MFI within the same immunologic EGIL group (European Group for the immunological classification of leukemias), indicating no influence of the B-ALLs EGIL subtype on the KMT2A-r+ B-ALLs immunophenotype. Conclusions Our data demonstrate the association between NG2 and KMT2A-r in B-ALLs identify a distinctive immunophenotypic pattern, useful for rapid identification in diagnostic routines of these subtypes of B-ALLs with a poor prognosis that benefits from a specific therapeutic approach.
Physical Fitness and Anthropometric Characteristics in School Children: A Comparison of Urban and Rural Areas in East Coast of Peninsular Malaysia

The objective of the study is to compare physical fitness between urban and rural school children and to determine relationship between body mass index and physical fitness primary school children in east coast of Peninsular Malaysia. This study is a cross-sectional study and conducted in primary schools. Anthropometric measurement involved weight and height measurement, and body mass index (BMI) calculation. Fitness test that were measured are power and flexibility. Power was measured by using Standing Broad Jump (SBJ), and flexibility test was measured using Sit and Reach Test (SRT). Total number of subjects were 14880, 71% (n=10532) were classified in normal BMI, and remaining 10% (n=1423) were in obesity; 9% (n=1303) were overweight, 8% (n=1164) were underweight; and 3% (n=458) were in severe thinness. In school area category, 59% (n=8769) rural school children and 41% (n=6111) urban school children. In conclusion, the current study found flexibility had shown a difference in area of school where urban school children performed slightly better than that of rural with F-value 2.09 (Pr>F= 0.15; p<0.05). It also showed a significant negative correlation between BMI and power (r=-0.12) with p-value was 0.0001. However, there was no significant difference in power with areas of school, and no correlation between flexibility and BMI.
The Impact of a Six-Hour Light–Dark Cycle on Wheat Ear Emergence, Grain Yield, and Flour Quality in Future Plant-Growing Systems

Cultivating wheat (Triticum aestivum) in a closed environment offers applications in both indoor farming and in outer-space farming. Tailoring the photoperiod holds potential to shorten the growth cycle, thereby increasing the annual number of cycles. As wheat is a long-day plant, a night shorter than a critical length is required to induce flowering. In growth chambers, experiments were conducted to examine the impact of a 6 h light–dark cycle on the timing of wheat ear emergence, grain yield, and flour quality. Under equal daily light-integral conditions, the 6 h light–dark cycle promoted growth and development, resulting in accelerated ear emergence when compared to a 12 h cycle, additionally indicating that 12 h of darkness was excessive. To further stimulate heading and increase yield, the 6 h cycle was changed at the onset of stem elongation to a 14 h–10 h, mimicking spring conditions, and maintained until maturity. This successful transition was then combined with two levels of light intensity and nutrient solution, which did not significantly impact yield, while tillering and grain ripening did increase under higher light intensities. Moreover, it enabled manipulation of the baking quality, although lower-end falling numbers were observed. In conclusion, combining a 6 h light–dark cycle until stem elongation with a 14 h–10 h cycle presents a promising strategy for increasing future wheat production in closed environments. The observation of low falling numbers underscores the importance of factoring in flour quality when designing the wheat-growing systems of the future.
A gelation analogy of crustal formation derived from fractal conductive structures

[1] The statistical evaluation of numerical random media models and of electromagnetic array data provides evidence of fractal conductive structures in the middle and lower crust. During the search for an electrical conduction mechanism that is compatible with the geophysical anomalies in the middle and lower crust, random resistor networks were developed. These networks contain two types of resistors, representing the rock matrix and the conductive phase. Here we demonstrate that random resistor network models can also explain the statistical properties of the electric field distortion measured in large-scale electromagnetic array experiments. Correspondence between measured and modeled distortion statistics is obtained if the structures formed by the two resistor types in the networks have a fractal geometry. This can indicate that the natural conductive networks also have a fractal geometry and stay close to a percolation threshold. A simple scale model of crust formation mechanics is considered in order to find an analog medium and an analog process that creates such a geometry. We suggest gelation as a rheological analogy that allows for a coexistence of ductile and brittle behavior of material in the lower crust. This process forms fractal structures in the host matrix and fractal conductive networks, provided that conductive material is available at that time of crustal evolution. The statistical evaluation of the field data provides evidence for a fractal structure with an upper bound of the size of Fennoscandia.
On How the Middle Atmospheric Residual Circulation Responds to the Solar Cycle Close to the Solstices

AbstractDuring high solar activity, the atmosphere receives more energy from the sun, particularly in the form of shortwave radiation. Most notable is the effect in the middle and upper atmosphere, which in general shows a positive temperature response due to physical and chemical processes that are intensified at high solar activity. It is thus surprising that a clear solar cycle signal is absent in the summer polar mesosphere region in spite of it being illuminated around the clock. In this study, it is investigated how the circulation in the summer mesosphere is affected by changes in the solar flux using a 30-yr run from the nudged version of the Canadian Middle Atmosphere Model (CMAM30). It is found that—in July—the solar cycle signal from direct solar heating is counteracted by an enhanced residual circulation, which adiabatically cools the region at a higher rate when the solar activity is above average. The dynamical cooling is partly initiated in the Southern Hemisphere winter stratosphere.
Nurses’ obesity knowledge, attitudes and practices in private facilities in Oshana, Namibia

Background The prevalence of obesity has been rising globally, and this is leading to an increase in other non-communicable diseases. The level of obesity knowledge among nurses may have an impact on how they treat and perceive obese patients. Aim The study aimed to ascertain the knowledge, attitudes and practices of nurses regarding obesity at private healthcare facilities located in Namibia’s Oshana Region. Setting A total of four private healthcare facilities in Namibia’s Oshana area served as the study’s sites. Methods A quantitative cross-sectional research design using proportional stratified random sampling was used to choose 250 respondents for the study. A questionnaire that respondents self-administered was used to gather the data. The reliability and validity of the questionnaire were determined during a pilot study. IBM Statistical Package for the Social Sciences (SPSS) version 27 was used for data analysis. Results Of the participants, about two-fifths had a positive attitude (n = 112; 44.8%), slightly less than two-fifths had good practices (n = 96; 38.4%) and more than one-third had good knowledge (n = 97; 39%). There were differences in knowledge mean scores based on age, occupation, sex and educational level. Conclusion The results validate the necessity for healthcare facilities to implement nurse education and mentorship initiatives, as well as to recognise and reward nurses who effectively care for patients with obesity. Contribution This study added literature on knowledge, attitudes and practices of nurses in private healthcare facilities in Namibia, as well as factors that influence knowledge levels among the nurses.
Characteristics of pulmonary artery strain assessed by cardiovascular magnetic resonance imaging and associations with metabolomic pathways in human ageing

Background Pulmonary artery (PA) strain is associated with structural and functional alterations of the vessel and is an independent predictor of cardiovascular events. The relationship of PA strain to metabolomics in participants without cardiovascular disease is unknown. Methods In the current study, community-based older adults, without known cardiovascular disease, underwent simultaneous cine cardiovascular magnetic resonance (CMR) imaging, clinical examination, and serum sampling. PA global longitudinal strain (GLS) analysis was performed by tracking the change in distance from the PA bifurcation to the pulmonary annular centroid, using standard cine CMR images. Circulating metabolites were measured by cross-sectional targeted metabolomics analysis. Results Among n = 170 adults (mean age 71 ± 6.3 years old; 79 women), mean values of PA GLS were 16.2 ± 4.4%. PA GLS was significantly associated with age (β = −0.13, P = 0.017), heart rate (β = −0.08, P = 0.001), dyslipidemia (β = −2.37, P = 0.005), and cardiovascular risk factors (β = −2.49, P = 0.001). Alanine (β = −0.007, P = 0.01) and proline (β = −0.0009, P = 0.042) were significantly associated with PA GLS after adjustment for clinical risk factors. Medium and long-chain acylcarnitines were significantly associated with PA GLS (C12, P = 0.027; C12-OH/C10-DC, P = 0.018; C14:2, P = 0.036; C14:1, P = 0.006; C14, P = 0.006; C14-OH/C12-DC, P = 0.027; C16:3, P = 0.019; C16:2, P = 0.006; C16:1, P = 0.001; C16:2-OH, P = 0.016; C16:1-OH/C14:1-DC, P = 0.028; C18:1-OH/C16:1-DC, P = 0.032). Conclusion By conventional CMR, PA GLS was associated with aging and vascular risk factors among a contemporary cohort of older adults. Metabolic pathways involved in PA stiffness may include gluconeogenesis, collagen synthesis, and fatty acid oxidation.
Instructor Leadership in Online Learning: Predictive Relationships Between Servant Leadership and the Community of Inquiry Framework

Instructor leadership is widely recognized as essential for facilitating meaningful online learning in higher education. While previous studies have applied organizational leadership theories to the study of instructor leadership, fewer studies have investigated online instructor leadership. This predictive correlational study detailed the associations between the Community of Inquiry (CoI) framework and servant leadership (SL) theory and employed multiple regression analyses to investigate the predictive relationships of seven SL dimensions on the three CoI presences. Survey data were gathered from 148 graduate students enrolled in online courses in education, communication, and engineering master’s degree programs using the CoI Survey (Arbaugh et al., 2008) and the SL-28 (Liden at al., 2008). The findings revealed a positive and highly significant correlation between the instruments. The predictive model as a whole explained 66% of the variance in students’ perceptions of a CoI. Three SL predictor variables demonstrated the most influence: helping subordinates grow and succeed, conceptual skills, and creating value for the community. Additional analyses at the CoI subscale level revealed that the SL variables accounted for 73% of the variance in teaching presence, 55% of the variance in cognitive presence, and 31% of the variance in social presence. Implications and limitations are discussed and recommendations are proposed to implement online instructor SL.
Microbial Alteration of Carbonate Archives

Marine biogenic carbonates are comprehensive archives of paleoenvironmental conditions. The main environmental variables that can be deduced from carbonate elemental- and isotopic composition are past sea-surface temperature (SST), salinity and related ocean circulation patterns, and trace element concentration. These parameters are crucial to understand paleo-ocean and atmospheric conditions, and to furthermore allow for interpolation to future environmental variables. However, the respective signals in carbonates can be biased by diagenetic alteration, and the abiotic processes involved in the diagenetic processes are being thoroughly investigated. A less considered, but potentially profound (co-) factor in earliest diagenesis are benthic microbial communities. Microbe-mineral interaction is known to shape the earth´s lithosphere through carbonate formation, dissolution, and geochemical alteration over geological timescales. However, the benthic microbial impact on marine carbonate archives after post mortem deposition in shallow sediments has rarely been included in diagenetic concepts so far. The present study investigates the carbonate-alteration potential of benthic microbe-mineral interaction during earliest diagenesis, thereby elucidating the underlying mechanisms - and the related consequences for carbonate-archive interpretation.
A Pan-African Convection-Permitting Regional Climate Simulation with the Met Office Unified Model: CP4-Africa

AbstractA convection-permitting multiyear regional climate simulation using the Met Office Unified Model has been run for the first time on an Africa-wide domain. The model has been run as part of the Future Climate for Africa (FCFA) Improving Model Processes for African Climate (IMPALA) project, and its configuration, domain, and forcing data are described here in detail. The model [Pan-African Convection-Permitting Regional Climate Simulation with the Met Office UM (CP4-Africa)] uses a 4.5-km horizontal grid spacing at the equator and is run without a convection parameterization, nested within a global atmospheric model driven by observations at the sea surface, which does include a convection scheme. An additional regional simulation, with identical resolution and physical parameterizations to the global model, but with the domain, land surface, and aerosol climatologies of CP4-Africa, has been run to aid in the understanding of the differences between the CP4-Africa and global model, in particular to .
Brief communication: Strengthening coherence between climate change adaptation and disaster risk reduction

Abstract. Reducing disaster risks and adapting to climate change are ever more important policy goals in Europe and worldwide. The commitment to the 2030 Agenda for Sustainable Development and complementary multilateral frameworks, including the Sendai Framework for Disaster Risk Reduction 2015–2030 and the Paris Agreement on Climate Change, has galvanized pursuits for policy coherence. The report Climate change adaptation and disaster risk reduction in Europe: enhancing coherence of the knowledge base, policies and practices of the European Environment Agency identified several ways for how coherence and resilience can be built through knowledge sharing, collaboration and investments.
On Death in the Mesolithic: Or the Mortuary Practices of the Last Hunter-Gatherers of the South-Western Iberian Peninsula, 7th–6th Millennium BCE

Peyroteo Stjerna, R. 2016. On Death in the Mesolithic. Or the Mortuary Practices of the Last Hunter-Gatherers of the South-Western Iberian Peninsula, 7–6 Millennium BCE. Occasional papers in archaeology 60. 511 pp. Uppsala: Department of Archaeology and Ancient History, Uppsala University. ISBN 978-91-506-2525-7. The history of death is entangled with the history of changing social values, meaning that a shift in attitudes to death will be consistent with changes in a society’s world view. Late Mesolithic shell middens in the Tagus and Sado valleys, Portugal, constitute some of the largest and earliest burial grounds known, arranged and maintained by people with a hunting, fishing, and foraging lifestyle, c 6000–5000 cal BCE. These sites have been interpreted in the light of economic and environmental processes as territorial claims to establish control over limited resources. This approach does not explain the significance of the frequent disposal of the dead in neighbouring burial grounds, and how these places were meaningful and socially recognized. The aim of this dissertation is to answer these questions through the detailed analysis of museum collections of human burials from these sites, excavated between the late nineteenth century and the 1960s. I examine the burial activity of the last hunter-gatherers of the south-western Iberian Peninsula from an archaeological perspective, and explain the burial phenomenon through the lens of historical and humanist approaches to death and hunter-gatherers, on the basis of theoretical concepts of social memory, place, mortuary ritual practice, and historical processes. Human burials are investigated in terms of time and practice based on the application of three methods: radiocarbon dating and Bayesian analysis to define the chronological framework of the burial activity at each site and valley; stable isotope analysis of carbon and nitrogen aimed at defining the burial populations by the identification of dietary choices; and archaeothanatology to reconstruct and define central practices in the treatment of the dead. This dissertation provides new perspectives on the role and relevance of the shell middens in the Tagus and Sado valleys. Hunter-gatherers frequenting these sites were bound by shared social practices, which included the formation and maintenance of burial grounds, as a primary means of history making. Death rituals played a central role in the life of these hunter-gatherers in developing a sense of community, as well as maintaining social ties in both life and death.
Overview of Forming Literature, 1990-2000

Paper structure characterisation has been extended to include 2-D formation and periodic marks as well as wavelet techniques. Local fibre orientation anisotropy and misalignment angle analysis, in combination with tape-splitting layering and image analysis have improved the understanding of the relationship between paper structure and properties as well as increased the possibilities to trace the forming history from final paper structure. The Crowding Factor has been introduced, to describe the tendency of fibre suspensions to form fibre flocs. It gives an improved predictability in comparison with fibre concentration, by also taking fibre slenderness into account. The dynamic characterisation of de-flocculating and re-flocculating mechanisms is getting increased attention, partly due to the potential of CCD-cameras and image analysis techniques. It is the opinion of the authors that floc stretching is a more promising way of de-flocculating than turbulent shear. It is doubtful whether turbulence in simple fluids can aim as a model for the flow irregularities in fibre suspensions, due to the damping effects of fibres and flocs. For headbox CD-profile control, dilution water injection has been introduced. Since this makes slice lip deformations un-needed, it has the potential to uncouple control of grammage and misalignment angle profiles and also to improve CD-control resolution. The importance of headbox nozzle design for fibre orientation anisotropy is now appreciated. A high nozzle contraction ratio will increase anisotropy and also introduce some deflocculation through floc stretching. Vane insertion helps to decrease fibre orientation anisotropy and is also applied for multi-layer forming. Although applied in tissue forming and in linerboard forming, further improvements have to be made for printing paper applications. In twin-wire forming, the roll-blade principle has been accepted by the main machine manufacturers. Since its introduction in the STFI-Former in 1991, the blade section design with stationary blades on one side and loadable blades on the opposite side is the main design for printing paper applications, and also increasingly used for different board qualities.
Molecular Identification and Detection of Virulence Genes Among Pseudomonas Aeruginosa Isolated from Burns Infections

Objective: Virulence factors are substances produced by pathogenic Pseudomonas aeruginosa that contribute significantly to the etiology of disease. These virulence factors are encoded by virulence genes found on the Pseudomonas aeruginosa chromosome. Methods: Between July 2021 and June 2022, 71 Pseudomonas aeruginosa isolates were identified from burn wounds at the Burn and Plastic Surgery Hospital in Duhok, Iraq. The lasB and toxA genes were identified using Polymerase Chain Reaction (PCR). Results: Only 26.36% (29/71) of the 71 Pseudomonas aeruginosa isolates were found in males, whereas 38.18% (42/71) were found in females. Furthermore, 76.06% (54/71) of the isolates were multidrug resistant. They demonstrated greater resistance to piperacillin, 98.59% resistance rates. Among the isolates analyzed, 35 (64.81%) were positive for toxA and 27 (50%) were positive for lasB genes. Conclusion: Due to the limited number of effective medications against this bacteria that are currently available, all isolates must undergo antimicrobial susceptibility testing. By doing this, you can help manage the treatment plan and stop the emergence of resistance in burn units.