Miracle-dz/UniFAR-FTUs huggingface dataset:
A Cross-Sectional Study on Hyomental Distance Ratio (HMDR) as a New Predictor of Difficult Laryngoscopy in ICU Patients

Background: Intubation in the ICU is sometimes unpredictable unlike in an operation theatre, where pre-anesthetic assessment for airway has been done. This study has been done to evaluate the usefulness of hyomental distance ratio (HMDR) in accurately predicting difficult laryngoscopy in ICU patients. Methods: In this study, 104 critically ill patients in the age group 18-70 years, undergoing tracheal intubation in ICU were included. A hard plastic ruler was pressed on the skin surface just above the hyoid bone and the distance to the tip of the anterior-most part of the mentum measured was defined as hyomental distance (HMD). HMD was assessed in neutral and extended head positions, and the HMDR was calculated. All patients were sedated, pre-oxygenated, induced, and relaxed prior to glottic visualization by direct laryngoscopy, which was performed by an experienced anesthetist. Cormack-Lehane's (CL's) grade was assessed without external laryngeal manipulation. Further management was as per ICU protocol. Results: Using the Chi-Square test for statistical analysis, a p-value of HMDR in assessing difficult laryngoscopy was found to be <0.001 suggesting strong significance. HMD in the extended head position (HDMe) showed moderate significance with a p-value of 0.047. HMDR <1.2 can be considered a clinically reliable individual predictor of difficult laryngoscopy in ICU patients. Conclusion: HMDR <1.2 can be used as a simple, easy, and reliable bedside test to predict difficult laryngoscopy amongst ICU patients. An optimal combination of tests is suggested if feasible for better accuracy.
Monthly Follow-Ups of Functional Status in People with COPD: A Longitudinal Study

Functional status is an important and meaningful outcome in people with chronic obstructive pulmonary disease (COPD), although its measurement is not embedded in routine clinical assessments. This study described the functional status of people with COPD using the 1-min sit-to-stand test (1minSTS) over a 6-month period and the examined sociodemographic and clinical characteristics associated with this outcome. Data from a prospective study including people with COPD were analyzed. Functional status was assessed monthly with the 1minSTS over 6 months. Linear-mixed effect models assessed the 1minSTS number of repetitions mean change. One-hundred and eight participants (82.4% men; 66.9 ± 9.5 years) were included. A significantly lower number of repetitions in the 1minSTS over the 6-month period was associated with being female (estimate: −4.69, 95%CI: −8.20; −1.18), being older (estimate: −0.56, 95%CI: −0.77; −0.34), having higher BMI (estimate: −0.55, 95%CI: −0.81; −0.28) and having higher activity-related dyspnea (estimate: −2.04, 95%CI: −3.25; −0.83). Half of the participants showed improvements above three repetitions in the 1minSTS over the 6-month period, independently of their baseline impairment (1minSTS < 70% predicted: 52.5%; ≥70% predicted: 54.4%). To conclude, monthly follow-up assessments were associated with clinically relevant benefits in the functional status of people with COPD. Age, body composition, and activity-related dyspnea were the main predictors of functional status over time. Further research is needed to corroborate our findings and to support the beneficial effects of regular COPD monitoring.
Green HRM and Organizational Sustainability: The Mediating Effect of Employees’ Attitudes during COVID-19 in the Jordanian Commercial Banking Sector

This article tested a structural model that investigates the relationship between Green Human Resource Management (GHRM) and Organizational Sustainability (OS), Green HRM and employee’s attitude during COVID-19 (CO), and CO and OS, further, the focus is on mediating role of CO in the link of GHRM and OS. Using a random sampling method, a survey was conducted on Jordanian commercial banks. In this study, the sample included 245 staff members working in Jordanian Commercial Banking. Analysis of the data involved the use of Structural Equation Modelling (SEM) by using SPSS AMOS tool. The results pointed out that GHRM was positively related to OS, GHRM exerted a significant positive effect on CO, and CO had a significant positive effect on OS. In regard to the CO role mediation on GHRM and OS relationship has equally been evaluated. Based on the theoretical and practical relevance, they entail highlighting the likelihood for future research direction building an evidence-based practice is the area of focus in the evidence-based aspects focused in this study.
HLA Genotypes and Type 1 Diabetes and Its Relationship to Reported Race/Skin Color in Their Relatives: A Brazilian Multicenter Study

We aimed to investigate the relationship between HLA alleles in patients with type 1 diabetes from an admixed population and the reported race/skin color of their relatives. This cross-sectional, multicenter study was conducted in public clinics in nine Brazilian cities and included 662 patients with type 1 diabetes and their relatives. Demographic data for patients and information on the race/skin color and birthplace of their relatives were obtained. Typing of the HLA-DRB1, -DQA1, and -DQB1 genes was performed. Most studied patients reported having a White relative (95.17%), and the most frequently observed allele among them was DRB1*03:01. Increased odds of presenting this allele were found only in those patients who reported having all White relatives. Considering that most of the patients reported having a White relative and that the most frequent observed allele was DRB1*03:01 (probably a European-derived allele), regardless of the race/skin color of their relatives, we conclude that the type 1 diabetes genotype comes probably from European, Caucasian ethnicity. However, future studies with other ancestry markers are needed to fill the knowledge gap regarding the genetic origin of the type 1 diabetes genotype in admixed populations such as the Brazilian.
Comparative study of intermediate-wave and catalytic infrared drying on the kinetics and physicochemical properties of pineapple rings

Abstract This comprehensive study examined the effects of two infrared drying modes: intermediate-wave infrared drying (IWD) and catalytic infrared drying (CID), on drying kinetics and various quality parameters of pineapple rings at 60–80 °C. Hot-air drying (HAD) was the control drying operation. CID showed the highest drying rates and coefficients of moisture diffusivity (3.05 × 10−8 m2/s to 5.12 × 10−8 m2/s), resulting in drying times (1.88–3.15 h) that were about half that of HAD (3.57–7.25 h) and 10–34% less than that of IWD (2.08–4.75 h). Compared to IWD, CID exhibited minor color changes and a stronger flavor profile and enzyme inactivation potential. However, it resulted in a hardened product surface, thus reducing the rehydration ability. Overall, CID exhibited higher bioactive retention rates, especially at 60 °C (56–87%), followed by IWD at 70 °C (50–80%) and 80 °C (35–90%). Based on the results of this study, CID produces superior quality dried pineapples in a significantly shorter drying time, which is of potential industrial interest.
The association of vitamin D, semen parameters, and reproductive hormones with male infertility: A cross-sectional study

Abstract Background The prevalence of vitamin D deficiency and male infertility is high in Iran. Objective The present research aimed to examine the association between serum vitamin D [25(OH)D], parameters of semen including semen volume, sperm count, motility and morphology, and reproductive hormones in infertile Iranian men. Materials and Methods This was a cross-sectional study on 119 infertile men conducted between September 2018 and May 2019. Subjects were divided into 3 groups based on serum vitamin D levels: deficient ( < 10 ng/mL), insufficient (10 ng/mL ≤ 25(OH)D ≤ 30 ng/mL), and sufficient ( > 30 ng/mL). Body mass index and waist circumference were measured. 25(OH)D, testosterone, sex hormone-binding globulin, luteinizing hormone (LH), follicle-stimulating hormone and estradiol levels, and semen parameters were assessed. Results The semen volume, sperm counts, total and progressively motile sperm, normal sperm morphology, testosterone levels, and testosterone/estradiol ratio were substantially higher in the sufficient group compared to the other groups (p < 0.001). Also, in the sufficient group, serum LH (p < 0.001) and estradiol (p < 0.001, p = 0.01) were notably lower and serum sex hormone-binding globulin (p < 0.001) and the testosterone/LH ratio (p < 0.001) were considerably higher compared to the insufficient and deficient groups. Conclusion Our study showed a positive relationship between serum vitamin D levels, and seminal parameters and sex hormones in Iranian infertile males.
From Skin Barrier Dysfunction to Systemic Impact of Atopic Dermatitis: Implications for a Precision Approach in Dermocosmetics and Medicine

Atopic dermatitis (AD) affects up to 20% of children and is considered the starting point of the atopic march with the development of food allergy, asthma, and allergic rhinitis. The heterogeneous phenotype reflects distinct and/or overlapping pathogenetic mechanisms with varying degrees of epidermal barrier disruption, activation of different T cell subsets and dysbiosis of the skin microbiome. Here, we review current evidence suggesting a systemic impact of the cutaneous inflammation in AD together with a higher risk of asthma and other comorbidities, especially in severe and persistent AD. Thus, early therapy of AD to restore the impaired skin barrier, modified microbiome, and target type 2 inflammation, depending on the (endo)phenotype, in a tailored approach is crucial. We discuss what we can learn from the comorbidities and the implications for preventive and therapeutic interventions from precision dermocosmetics to precision medicine. The stratification of AD patients into biomarker-based endotypes for a precision medicine approach offers opportunities for better long-term control of AD with the potential to reduce the systemic impact of a chronic skin inflammation and even prevent or modify the course, not only of AD, but possibly also the comorbidities, depending on the patient’s age and disease stage.
Diagnosis of Liver Tumors in Human CT Images Based on the LiverNet Approach

Liver cancer contributes to the increasing mortality rate in the world. Therefore, early detection may lead to a decrease in morbidity and increase the chance of survival rate. This research offers a computer-aided diagnosis system, which uses computed tomography scans to categorize hepatic tumors as benign or malignant. The 3D segmented liver from the LiTS17 dataset is passed through a Convolutional Neural Network (CNN) to detect and classify the existing tumors as benign or malignant. In this work, we propose a novel light CNN with eight layers and just one conventional layer to classify the segmented liver. This proposed model is utilized in two different tracks; the first track uses deep learning classification and achieves a 95.6% accuracy. Meanwhile, the second track uses the automatically extracted features together with a Support Vector Machine (SVM) classifier and achieves 100% accuracy. The proposed network is light, fast, reliable, and accurate. It can be exploited by an oncological specialist, which will make the diagnosis a simple task. Furthermore, the proposed network achieves high accuracy without the curation of images, which will reduce time and cost.
Effects of COVID-19 Restriction Policies on Urban Heat Islands in Some European Cities: Berlin, London, Paris, Madrid, and Frankfurt

The present study investigates the effects of policies restricting human activities during the COVID-19 epidemic on the characteristics of Night Land Surface Temperature (NLST) and Night Urban Heat Islands (NUHI) in five major European cities. In fact, the focus of this study was to explore the role of anthropogenic factors in the formation and intensity of NUHI. The effect of such factors was uncontrollable before the COVID-19 outbreak on the global scale and in a real non-laboratory environment. In this study, two indices, the concentration of Nitrogen dioxide (NO2) and Nighttime Lights (NL), were used as indicators of the number of anthropogenic activities. The data were collected before the COVID-19 outbreak and after its prevalence in 2019–2020. A Paired samples t-test and a Pearson correlation were used to examine the differences or significant relationships between the variables and indicators studied throughout the two periods. The results of the study confirmed a direct and significant relationship between NO2 and NL indices and the NUHI and NLST variables; however, using strict restrictions during the COVID-19 pandemic, the NO2 and NL indices decreased seriously, leading to significant changes in the characteristics of the NUHI and NLST in the five cities. This study has some implications for urban planners and politicians, e.g., the environmental impacts of changing the nature and level of anthropogenic activities can greatly affect the pattern and intensity of the Urban Heat Islands (UHIs) (as a serious environmental challenge).
Experimental Study of Coupled Flow through Combined Weir - Gate Structure

This study presents a series of experimental investigations on combined flow over curved weirs and below rectangular gate to find the hydraulic characteristics of the flow. Six combined parabolic bottom triangular weirs were constr ucted and tested for two different triangular angles ( θ w = 45  and 60  ) respectively. A generalized discharge model is proposed relating the discharge coefficient(C d ) , the weir head(h w ), gate opening ratio parameter in addition to weir geometry, the dista nce between the weir and the gate (Z), and weir opening ratio (b w /h w ). Analysis of the results revealed that discharge equation is suitable for horizontal channel bed under submerged flow and for free flow. The predictions of equation shows fair agreement with experimental data.
Difference in Quality of Vision Outcome among Extended Depth of Focus, Bifocal, and Monofocal Intraocular Lens Implantation

We aimed to compare the postoperative quality of vision among patients who received extended depth of focus (EDOF), bifocal, and monofocal intraocular lens (IOL) implantation. A retrospective study was conducted, and 87 patients who underwent cataract surgery were enrolled. Patients were categorized into different groups according to IOL design, with 24, 29, and 34 individuals constituting bifocal, EDOF, and monofocal groups. Preoperative and postoperative visual acuity (VA), biometry data, refractive status, contrast sensitivity (CS), higher-order aberrations (HOAs), and a quality of vision questionnaire that consisted of 11 questions were obtained 1 month postoperatively. The Kruskal–Wallis test and Pearson’s chi-square test were applied for statistical analyses. The postoperative CDVA was better in the EDOF group than in the bifocal group (p = 0.043), and the residual cylinder was lower in the EDOF groups than in the other two groups (both p < 0.05). The CS was worse in the EDOF group than in the other two groups (all p < 0.05), while the spherical aberration and trefoil were lower in the EDOF group than in the bifocal group (both p < 0.05). In terms of the quality of vision, the scores were better in the monofocal group than in the EDOF group in seven items (all p < 0.05), and the quality of vision in the bifocal group was better than in the EDOF group in small print reading (p = 0.042). In addition, the incidence of glare was lower in the monofocal group than in the other two groups (p < 0.001), while the spectacle dependence ratio was significantly higher in the monofocal group compared to the other two groups (p < 0.001). In conclusion, the general quality of vision was better in the monofocal group compared to the bifocal and EDOF groups, while the spectacle dependence ratio was significantly higher in the monofocal group than in the other two groups.
Immunogenicity of MultiTEP-Platform-Based Recombinant Protein Vaccine, PV-1950R, Targeting Three B-Cell Antigenic Determinants of Pathological α-Synuclein

Parkinson’s disease (PD) and dementia with Lewy bodies (DLB) are characterized by the aberrant accumulation of intracytoplasmic misfolded and aggregated α-synuclein (α-Syn), resulting in neurodegeneration associated with inflammation. The propagation of α-Syn aggregates from cell to cell is implicated in the spreading of pathological α-Syn in the brain and disease progression. We and others demonstrated that antibodies generated after active and passive vaccinations could inhibit the propagation of pathological α-Syn in the extracellular space and prevent/inhibit disease/s in the relevant animal models. We recently tested the immunogenicity and efficacy of four DNA vaccines on the basis of the universal MultiTEP platform technology in the DLB/PD mouse model. The antibodies generated by these vaccines efficiently reduced/inhibited the accumulation of pathological α-Syn in the different brain regions and improved the motor deficit of immunized female mice. The most immunogenic and preclinically effective vaccine, PV-1950D, targeting three B-cell epitopes of pathological α-Syn simultaneously, has been selected for future IND-enabling studies. However, to ensure therapeutically potent concentrations of α-Syn antibodies in the periphery of the vaccinated elderly, we developed a recombinant protein-based MultiTEP vaccine, PV-1950R/A, and tested its immunogenicity in young and aged D-line mice. Antibody responses induced by immunizations with the PV-1950R/A vaccine and its homologous DNA counterpart, PV-1950D, in a mouse model of PD/DLB have been compared.
Expression Profile and Diagnostic Significance of MicroRNAs in Papillary Thyroid Cancer

Simple Summary In recent years, the incidence of papillary thyroid cancer (PTC) has increased in many countries worldwide. MicroRNAs appear to be important regulators of PTC, but a better understanding of their role is needed to develop novel diagnostic tools and identify potential vulnerabilities. In this study, we aimed to gain insight into the microRNA profile of PTC tissue. Consequently, crucial pathways in PTC were highlighted. A panel of four microRNAs (miR-152-3p, miR-221-3p, miR-551b-3p, and miR-7-5p) was proposed as a PTC diagnostic biomarker. Our analysis indicated that microRNAs are a potential diagnostic tool for PTC patients. Abstract The incidence of papillary thyroid cancer (PTC) has increased in recent years. To improve the diagnostic management of PTC, we propose the use of microRNAs (miRNAs) as a biomarker. Our aim in this study was to evaluate the miRNA expression pattern in PTC using NanoString technology. We identified ten miRNAs deregulated in PTC compared with reference tissue: miR-146b-5p, miR-221-3p, miR-221-5p, miR-34-5p, miR-551b-3p, miR-152-3p, miR-15a-5p, miR-31-5p, and miR-7-5p (FDR < 0.05; |fold change (FC)| ≥ 1.5). The gene ontology (GO) analysis of differentially expressed miRNA (DEM) target genes identified the predominant involvement of epidermal growth factor receptor (EGFR), tyrosine kinase inhibitor resistance, and pathways in cancer in PTC. The highest area under the receiver operating characteristic (ROC) curve (AUC) for DEMs was found for miR-146-5p (AUC = 0.770) expression, indicating possible clinical applicability in PTC diagnosis. The combination of four miRNAs (miR-152-3p, miR-221-3p, miR-551b-3p, and miR-7-5p) showed an AUC of 0.841. Validation by real-time quantitative polymerase chain reactions (qRT-PCRs) confirmed our findings. The introduction of an miRNA diagnostic panel based on the results of our study may help to improve therapeutic decision making for questionable cases. The use of miRNAs as biomarkers of PTC may become an aspect of personalized medicine.
Climate Leads to Reversed Latitudinal Changes in Chinese Flood Peak Timing

Changes in river floods under a changing climate are of worldwide concerns, but relevant knowledge is limited especially over the East Asia monsoon region. Here we examine changes in flood peak timing based on the most comprehensive flood data set to date across China during 1961–2017. The temporal shifts of Chinese flood peak timing range from −19.0 days earlier to +14.0 days later per decade. Earlier flood occurrences are mainly observed in northern China, with delayed flood occurrences in the south. The spatial pattern of reversed latitudinal changes in flood timing leads to growing spatial extents of concurrent river floods over China. Soil moisture plays an important role in modulating such changes, despite precipitation determines the climatological mean dates of flood occurrences. Our results highlight a strong climate signal on the changes in flood timing over China, and call for coordinated efforts in alleviating expanding flood hazards related to the changes in flood timing.
An Assessment of Airborne Bacteria and Fungi in the Female Dormitory Environment: Level, Impact Factors and Dose Rate

In this study, the levels of airborne bacteria and fungi were tested in a female dormitory room; the effects of heating, relative humidity and number of occupants on indoor microorganisms were analyzed and the dose rate of exposure to microbes was assessed. The bacterial and fungal concentrations in the room ranged from 100 to several thousand CFU/m3, and the highest counts were observed in the morning (930 ± 1681 CFU/m3). Staphylococcus spp. and Micrococcus spp. were found in the dormitory. When the heating was on, the total bacterial and fungal counts were lower than when there was no heating. Moreover, statistically significant differences were observed for bacterial concentrations during the morning periods between the times when there was no heating and the times when there was heating. The number of occupants had an obvious positive effect on the total bacterial counts. Moreover, RH had no correlation with the airborne fungi in the dormitory, statistically. Furthermore, the highest dose rate from exposure to bacteria and fungi was observed during sleeping hours. The dose rate from exposure to airborne microorganisms in the dormitory was associated with the activity level in the room. These results helped to elucidate the threat of bioaerosols to the health of female occupants and provide guidance for protective measures.