Miracle-dz/UniFAR-FTUs huggingface dataset:
disorder and other neurodevelopmental disorders in offspring of parents with depression and bipolar disorder

Background. Offspring of parents with major mood disorders (MDDs) are at increased risk for early psychopathology. We aim to compare the rates of neurodevelopmental disorders in offspring of parents with bipolar disorder, major depressive disorder, and controls. Method. We established a lifetime diagnosis of neurodevelopmental disorders [attention-def-icit/hyperactivity disorder (ADHD), autism spectrum disorder, communication disorders, intellectual disabilities, specific learning disorders, and motor disorders] using the Kiddie Schedule for Affective Disorders and Schizophrenia, Present and Lifetime Version in 400 participants (mean age 11.3 + S . D . 3.9 years), including 93 offspring of parents with bipolar disorder, 182 offspring of parents with major depressive disorder, and 125 control offspring of parents with no mood disorder. Results. disorders were elevated in offspring of parents with bipolar disorder [odds ratio (OR) 2.34, 95% confidence interval (CI) 1.23 – 4.47, p = 0.010] and major depressive disorder (OR 1.87, 95% CI 1.03 – 3.39, p = 0.035) compared to controls. This difference was driven by the rates of ADHD, which were highest among offspring of parents with bipolar disorder (30.1%), intermediate in offspring of parents with major depressive disorder (24.2%), and lowest in controls (14.4%). There were no significant differences in frequencies of other neurodevelopmental disorders between the three groups. Chronic course of mood disorder in parents was associated with higher rates of any neurodevelopmental disorder and higher rates of ADHD in offspring. Conclusions. Our findings suggest monitoring for ADHD and other neurodevelopmental disorders in offspring of parents with MDDs may be indicated to improve early diagnosis and treatment.
Summary of 2006 to 2010 FPMU Measurements of International Space Station Frame Potential Variations

Electric potential variations on the International Space Station (ISS) structure in low Earth orbit are dominated by contributions from interactions of the United States (US) 160 volt solar arrays with the relatively high density, low temperature plasma environment and inductive potentials generated by motion of the large vehicle across the Earth? s magnetic field. The Floating Potential Measurement Unit (FPMU) instrument suite comprising two Langmuir probes, a plasma impedance probe, and a floating potential probe was deployed in August 2006 for use in characterizing variations in ISS potential, the state of the ionosphere along the ISS orbit and its effect on ISS charging, evaluating effects of payloads and visiting vehicles, and for supporting ISS plasma hazard assessments. This presentation summarizes observations of ISS frame potential variations obtained from the FPMU from deployment in 2006 through the current time. We first describe ISS potential variations due to current collection by solar arrays in the day time sector of the orbit including eclipse exit and entry charging events, potential variations due to plasma environment variations in the equatorial anomaly, and visiting vehicles docked to the ISS structure. Next, we discuss potential variations due to inductive electric fields generated by motion of the vehicle across the geomagnetic field and the effects of external electric fields in the ionosphere. Examples of night time potential variations at high latitudes and their possible relationship to auroral charging are described and, finally, we demonstrate effects on the ISS potential due to European Space Agency and US plasma contactor devices.
Unexpected Universality in Disordered Systems and Modeling Perpendicular Recording Media

In this thesis, I study the random-field Ising model (RFIM) in both theoretical and applied perspectives. For theoretical interests, I compare the avalanche behavior in equilibrium and non-equilibrium and find an unexpected universality. The application part focuses on the reliability test of the ∆H(M,∆M) methodology, which has been used to measure microscopic properties of magnetic recording media. Based on RFIM, an interacting random hysteron model has been developed and used to systematically test the reliability of the ∆H(M,∆M) methodology. Avalanche behavior in response to slowly changing external conditions is ubiquitous in a remarkably wide variety of dynamical systems. When driven far from equilibrium, those systems display impulsive cascade of dynamic avalanches spanning a broad range of sizes. Independent of their microscopic details, many non-equilibrium systems have been shown to have exactly the same dynamic avalanche behavior on many scales. This fact is called universality. So far, nonequilibrium systems were believed to be completely different from equilibrium ones. However, here we show that the zero-temperature RFIM exhibits surprisingly similar avalanche behavior in equilibrium and out of equilibrium. This finding solves a highly controversial question, i.e. whether the equilibrium and non-equilibrium disorder-induced phase transitions of RFIM belong to the same universality class. Our finding also indicates that generally equilibrium systems and their non-equilibrium counterparts may have deep connections. In state-of-the-art storage applications such as hard disk drives, the intrinsic switching field distribution of the media grains is one of the most crucial properties defining the recording quality. However, this piece of microscopic information is very hard to measure macroscopically, especially for the perpendicular recording media. Using the interacting random hysteron model, we have studied the reliability of the recently developed ∆H(M,∆M) method. We demonstrated that this method does have several advantages over comparable methods. First, it has a well-defined reliability range and it allows for selfconsistency checks. Second, the presence of dipolar interactions in the range of typical recording media substantially enhances the reliability of this method. Third, it is robust even in the presence of randomness in exchange or magnetostatic coupling within the range of a typical recording media.
THE INTERNATIONAL JOURNAL OF BUSINESS & MANAGEMENT Examining Effective Human Resource Management Practices on Employee Retention: Tamale Technical University as a Case Study

: Human resource practices play a significant role in supporting the achievement of the corporate objective of educational institutions including the Tamale Technical University, however, the Technical University continue to experience some difficulties following the challenges associated with employee retention in the Technical University. Retention of talented employees has become an even greater challenge confronting human resource practitioners since talented candidates in the job market are at liberty of choice to move. Given the above issue, this study was carried to examine the effectiveness of Human Resource Management (HRM) practices on employees’ retention at Tamale Technical University. Using both the purposive and stratified sampling technique, a sample of 100 respondents was selected from the various units of the Technical University for data collection. The study sought to establish human resource management practice correlates with the retention of employees in the Tamale Technical University. The results which are represented by a valuer = 0.02 lie in the range of r = -1 to r = +1, therefore indicate a weak positive relationship between HRM practices and employee retention in the Tamale Technical University’s bid to achieve its corporate goal and objective. The study disclosed that HRM practices such as effective communication with the employee on welfare issues, employee participation in the policies that guide working lives, praise and appreciation of good work was done as well as annual awards for hard-working employees can encourage employees to stay, but not sufficient enough to guarantee a total employee retention in the Tamale Technical University. The Technical University should continue to provide training and development for the entire staff. Recognition and rewards should be awarded to deserving officers in other to motivate and retain them. For the effectiveness of HRM practices, interpersonal relations should always be established among employees. Performance appraisal systems should be used as a tool for measuring performance against standards and for selecting employees for training and development. namely, organizational and HRM policies and practices. Available demonstrates that the fundamental HRM practices include human resource planning, recruitment, and selection, job analysis; compensation and reward, performance appraisal, training and development, career management, employee relations, and welfare (Armstrong, 2006). section focused on the vibrancy of the Human Resource Management Unit of Tamale Technical University; the importance of Human Resource Management practices, the strategic approach of HR aimed at managing labor and employee relations; HR strategies aimed at maximizing employee’s potential and their commitments; reward systems for employees with positive behavior or exerted energy and other comprehensive HRM practices that support management to grow.
Evidence for an Activation Domain at the Amino Terminus of Simian Immunodeﬁciency Virus Vpx (cid:1) †

Vpx and Vpr are related lentiviral accessory proteins that enhance virus replication in macrophages and dendritic cells. Both proteins are packaged into virions and mediate their effects in the target cell through an interaction with an E3 ubiquitin ligase that contains DCAF1 and DDB1. When introduced into primary macrophages and dendritic cells in viruslike particles, Vpx can enhance the efﬁciency of a subsequent infection. Here, we conﬁrm the ability of Vpx to enhance simian immunodeﬁciency virus (SIV) and human immunode- ﬁciency virus type 1 (HIV-1) infection of macrophages up to 100-fold by using single-cycle reporter viruses and by pretreatment of the cells with Vpx-containing viruslike particles. Vpx was also active in differentiated THP-1 cells but not in other cell lines. Induction of an antiviral state in macrophages with type I interferon signiﬁcantly magniﬁed the effect of Vpx on HIV-1 infection, suggesting that Vpx helps the virus to overcome an inducible intracellular restriction. Quantitative PCR quantitation of SIV and HIV-1 reverse transcripts in newly infected macrophages showed that the block was at an early step in reverse transcription. In spite of its structural similarity, Vpr was inactive. This difference allowed us to map the functional domains of Vpx with a panel of Vpr/Vpx chimeras. Analysis of the chimeras demonstrated that the amino-terminal domain of Vpx is important for the enhancement of infection. Fine mapping of the region indicated that amino acids at positions 9, type were type infected at a multiplicity (MOI) of with stocks been treated (Invitrogen)/ml remove the plasmid To control for residual plasmid 25 M one isolated and 48 h Reverse
Inﬂuence of Clay Calcination Method on the Mechanical Properties and Chloride Di ﬀ usion Resistance of Limestone Calcined Clay Cement (LC3) Concrete

: Calcined clay plays an important role in the performance of limestone calcined clay cement (LC3) concrete. In this study, the performance of two di ﬀ erent types of calcined clay produced from di ﬀ erent calcination processes were investigated in chloride environment. The characteristics of the calcined clays, including mineral composition, chemical composition, particle size distribution, speciﬁc surface area and particle morphology, were evaluated. Based on the reactivity of the calcined clays, the compressive strength of concretes after up to 28 days of curing was adopted as the best measure to determine the appropriate replacement levels of Portland cement by LC3 to satisfy standards requirements for concrete in chloride environments. The chloride bulk di ﬀ usion test was conducted to investigate the performance of LC3 concretes in comparison with reference Portland cement concrete. Similar chloride di ﬀ usion resistance could be achieved by using the two di ﬀ erent calcined clays in LC3 concrete. The performance of both LC3 concretes was much better than that of reference concrete. However, the Portland cement substitution rate for each calcined clay was governed by the compressive strength standard requirements.
metabolites Vitamin D, Bone Metabolism, and Fracture Risk in Polycystic Ovary Syndrome

: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder among premenopausal women. PCOS may have reproductive, metabolic, cardiovascular, and psychological implications. Vitamin D deﬁcit is often encountered in PCOS women and may contribute to the pathophysiology of this disorder. As of the key role of vitamin D in bone and mineral metabolism, and because the vitamin D status appears to be closely linked with the PCOS manifestations including insulin resistance, obesity, ovulatory and menstrual irregularities, oxidative stress and PTH elevation, hypovitaminosis D may directly and indirectly via the different facets of PCOS impair bone health in these women. Although limited data are available on life-long fracture risk in women with PCOS, the importance of preserving bone health in youth and adults to prevent osteoporosis and related fractures is also recognized in PCOS women. Evidence of the association between vitamin D and the clinical hallmarks of PCOS are summarized and discussed. Vitamin D arises as a cornerstone in women with PCOS and contributes to the pathophysiological link between PCOS and bone metabolism.
The unfolded protein response modulates a phosphoinositide-binding protein 11 through the IRE1-bZIP60 pathway

37 Phosphoinositides function as lipid signals in plant development and stress tolerance by 38 binding with partner proteins. We previously reported that Arabidopsis ( Arabidopsis 39 thaliana ) phosphoinositide-specific phospholipase C2 (PLC2) functions in the 40 endoplasmic reticulum (ER) stress response. However, the underlying molecular 41 mechanisms of how phosphoinositides act in the ER stress response remain elusive. 42 Here, we report that a phosphoinositide-binding protein, SMALLER TRICHOMES WITH 43 VARIABLE BRANCHES ( SVB ), is involved in the ER stress tolerance. SVB contains a 44 DUF538 domain with unknown function; orthologs are exclusively found in 45 Viridiplantae (green plants). We established that SVB is ubiquitously expressed in plant 46 tissues and is localized to the ER, Golgi apparatus, prevacuolar compartment, and plasma 47 membranes. The knockout mutants of svb showed enhanced tolerance to ER stress, 48 which was genetically complemented by transducing genomic SVB . SVB showed 49 time-dependent induction after tunicamycin-induced ER stress, which depended on 50 IRE1 and bZIP60 but not bZIP17 and bZIP28 in the unfolded protein response (UPR). 51 A protein–lipid overlay assay showed specific binding of SVB to phosphatidylinositol 52 3,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. SVB is therefore 53 suggested to be the plant-specific phosphoinositide-binding protein whose expression is 54 controlled by the UPR through the IRE1-bZIP60 pathway in Arabidopsis . 55
E ﬀ ects of Exogenous Dietary Advanced Glycation End Products on the Cross-Talk Mechanisms Linking Microbiota to Metabolic Inﬂammation

: Heat-processed diets contain high amounts of advanced glycation end products (AGEs). Here we explore the impact of an AGE-enriched diet on markers of metabolic and inﬂammatory disorders as well as on gut microbiota composition and plasma proteins glycosylation pattern. C57BL / 6 mice were allocated into control diet (CD, n = 15) and AGE-enriched diet (AGE-D, n = 15) for 22 weeks. AGE-D was prepared replacing casein by methylglyoxal hydroimidazolone-modiﬁed casein. AGE-D evoked increased insulin and a signiﬁcant reduction of GIP / GLP-1 incretins and ghrelin plasma levels, altered glucose tolerance, and impaired insulin signaling transduction in the skeletal muscle. Moreover, AGE-D modiﬁed the systemic glycosylation proﬁle, as analyzed by lectin microarray, and increased N ε -carboxymethyllysine immunoreactivity and AGEs receptor levels in ileum and submandibular glands. These e ﬀ ects were associated to increased systemic levels of cytokines and impaired gut microbial composition and homeostasis. Signiﬁcant correlations were recorded between changes in bacterial population and in incretins and inﬂammatory markers levels. Overall, our data indicates that chronic exposure to dietary AGEs lead to a signiﬁcant unbalance in incretins axis, markers of metabolic inﬂammation, and a reshape of both the intestinal microbiota and plasma protein glycosylation proﬁle, suggesting intriguing pathological mechanisms underlying AGEs-induced metabolic derangements. Comparative analysis for individual lectins showed signiﬁcant di ﬀ erences between CD and AGE-D groups. Binding on AIA, WGA, and SNA-I with labelled IgG fractions was signiﬁcantly increased in the AGE-D group (Figure 4A), suggesting an increase in galactose (AIA binding), presence of N-acetylglucosamine residues (WGA binding) and sialylation which would most likely be terminal α -(2,6) linked sialic acid (WGA and SNA-I binding). On the other hand, binding on AIA and PHA-E was signiﬁcantly decreased in the AGE-D group in the DP fractions (Figure 4B), implying a decrease in galactose (AIA binding) and N-linked complex type structures with β -linked Gal or Gal- β -(1,4)GlcNAc termini, with or without bisecting GlcNAc (PHA-E binding).
Growth of four generations of Zebra-snout Seahorse, Hippocampus barbouri (Jordan & Richardson, 1908) in captivity

: This study was conducted to determine the effect of different generations affecting the size of Hippocampus barbouri in captivity. Seahorse in-house breeding was carried out in Fisheries Research Institute, Penang. Adults H. barbouri were conditioned prior to breeding. All newborn H. barbouri juveniles were transferred to rearing tank once they were born. Growth of H. barbouri juveniles was measured at 10 days interval, up to 60 days. Results showed that different F2 H. barbouri juveniles recorded the smallest size when compared to other generations at day 10 after birth. However, starting from day 50 after birth to day 60 after birth, F2 H. barbouri juveniles recorded the best growth when compared to other generations. Although F3 H. barbouri juveniles had better growth from day 10 of birth until day 40 of birth, the growth was limited after day 50 of birth. F4 and F5 H. barbouri juveniles had similar finding as F3. One of the possible reasons was due to feeding. At initial stage of life, H. barbouri juveniles were fed with newly hatch Artemia nauplii. Starting from day 40, H. barbouri juveniles were weaned over to live Mysis and adult Artemia . Inconsistency supply of live mysids due to monsoon season might affect growth of H. barbouri . Moreover, nutritional content of adult Artemia was another concern. To conclude, culture of H. barbouri in captivity is feasible, where growth of H. barbouri can reach maximum height of 72 mm at day 60 of birth, with the survival rate of more than 43%.
CFD Study On the Behaviour and Turbulence of the Airflow Induced by The Moving Elevator Car in Elevator Shaft Using K-Epsilon Model

Land scarcity in relation to the swift urbanisation causes vertical development of buildings and infrastructures. The increasing importance of the main vertical transport - elevator, urges the elevator aerodynamics study to evaluate its acoustic, ride comfort, aerodynamics performance, and airflow effect. They were carried out experimentally or(and) via modeling and simulation. However, among the very limited published CFD studies on the elevator aerodynamics, there is insufficient detailed method and data been presented. Consequently, there is a very limited open-source established method and preliminary data necessary for the elevator aerodynamic study, restricting the potential improvement in this topic. Therefore, this paper studies the behaviour and turbulence of the airflow induced by the elevator car movement in the elevator shaft using the PIMPLE algorithm and the k-epsilon model. Details on the theories and methods were explained and discussed, which include the computational domain settings, governing principles and equations, numerical methods and mechanisms, and boundary conditions. An unsteady, turbulent, incompressible, and Newtonian airflow was assumed in the OpenFOAM simulation. The airflow was affected mainly by the blockage effect and the Bernoulli’s effect. The simulation result obeys the theories of fluid mechanics and physics, indicating its reliability to be the preliminary data for further study.
Significance of a single time point hybrid-protocol for somatostatin receptor SPECT including multiphase CT in the diagnostic work-up of gastroenteoropancreatic neuroendocrine Neoplasms (GEP-NEN).

: Aim: This prospective study compared a one-day hybrid-SPECT/CT protocol (incl. multiphase CT-scans) to the commonly used three-day protocol for somatostatin receptor scintigraphy (SRS) in patients suffering from gastroenteropancreatic neuroendocrine neoplasms (GEP-NEN). Additionally, the SPECT/CT-influence on patient management was evaluated. Methods: From 10/2011 to 10/2012 all GEP-NEN-patients undergoing restaging with SRS with a modern SPECT/CT-device SPECT/CT (Discovery NM/CT670, GE) were enrolled in this study. The examination-protocol consisted of planar scanning 4, 24 and 48 h p.i. , whole-body low-dose SPECT/CT-imaging at 24 and 48 h (SPECT-ldCT24, SPECT-ldCT48) and diagnostic multiphase CT (dCT24) at 24 h coregistered to the corresponding SPECT (SPECT-ldCT24). All imaging data-components were reassessed by three blinded readers (R1, R2, R3). The results were compared to a reference standard (RS) based on all clinical, imaging and histopathology follow-up data available (24-36, mean 29.9 months). RS was defined by a study-specific interdisciplinary tumor board (SITB) that also reassessed treatment decisions. Results: 31 patients (m, n=18; f, n=13; mean age, 60.4 years) were eligible for analysis. 10/31 patients had no imaging sign of disease and remained disease-free during follow-up. 21/31 patients had persistent/recurrent disease (n=82 lesions: liver n=24; lymph-node n=21; bone n=16; pancreas n=12; others n=9). A lesional detection rate of 51.9%(R1), 49.4%(R2) and 71.6%(R3) for SPECT-ldCT24, 51.9%(R1), 55.6%(R2) and 67.9%(R3) for SPECT-ldCT48 and 63.0%(R1), Integrated SPECT/CT reading influenced therapeutic management in 8/31 (25.8%) patients. Conclusion: The highest detection rates are achieved by SPECT-dCT24. Thus, a more patient-friendly one-day-examination protocol is feasible. Furthermore, the multiphase hybrid-SPECT/CT-examination impacted on patient management in about one fourth of all patients.
The use of blog to facilitate clinical learning during practicum among undergraduate students: a preliminary study

(2009). The use of blog to facilitate clinical learning during practicum among undergraduate nursing students: a preliminary study. Proceedings of the 2009 International Conference on Knowledge Management Blogging has been increasingly used in the education field. This study is the first to explore the use of blogging to facilitate clinical learning for undergraduate nursing students (N=57) with surface or deep study approaches during their clinical practicum in Hong Kong. The findings indicated that blogging is useful in facilitating clinical learning as it fulfills different learning styles and needs of students by promoting information and knowledge sharing, enhancing self- reflection and providing emotional support.