Miracle-dz/UniFAR-FTUs huggingface dataset:
The Outermost Ejecta of Type Ia Supernovae

The properties of the highest velocity ejecta of normal Type Ia supernovae (SNe Ia) are studied via models of very early optical spectra of six SNe. At epochs earlier than 1 week before maximum, SNe with a rapidly evolving Si II λ6355 line velocity (HVG) have a larger photospheric velocity than SNe with a slowly evolving Si II λ6355 line velocity (LVG). Since the two groups have comparable luminosities, the temperature at the photosphere is higher in LVG SNe. This explains the different overall spectral appearance of HVG and LVG SNe. However, the variation of the Ca II and Si II absorptions at the highest velocities (v≳ 20,000 km s−1) suggests that additional factors, such as asphericity or different abundances in the progenitor white dwarf, affect the outermost layers. The C II λ6578 line is marginally detected in three LVG SNe, suggesting that LVGs undergo less intense burning. The carbon mass fraction is small, only less than 0.01 near the photosphere, so that he mass of unburned C is only ≲0.01 M☉. Radioactive 56Ni and stable Fe are detected in both LVG and HVG SNe. Different Fe-group abundances in the outer layers may be one of the reasons for spectral diversity among SNe Ia at the earliest times. The diversity among SNe Ia at the earliest phases could also indicate an intrinsic dispersion in the LC width-luminosity relation.
Metaphoric construal and its effect on gaze behavior of the readers with better and worse working memory

Language creativity studies are now exploring new experimental methods which test the readers’ figurative thought. In the current work, we address the gaze behavior as contingent on figurative language construal in two participants’ groups with different amount of working memory. We verify the hypothesis that apart from metaphor types, novel and entrenched, gaze behavior is affected by metaphor construal patterns, here described as parameters. The study specifies the cognitive parameters of Referent construal, Event Frame construal, Perspective construal, and the linguistic parameters of graphological, lexical and syntactic construal. Regression analysis reveals several predictors of steady decrease and increase of the gaze costs within two participant groups. The participants with better working memory display higher gaze costs when the construal lacks action or dynamics; whereas the participants with worse working memory are affected by both linguistic and cognitive construal parameters including Clause-initial position for contrastive focus, Lexical synonyms and antonyms, Spontaneous or occasional event, Lack of action or dynamics. We also identified the predictors which decrease the gaze costs; the participants with worse working memory are affected by Perception (Event type), Shifting / changing, Agentive participant, Intensifiers in pre-position. Overall, the participants with worse working memory pay more attention to linguistic construal of metaphors, presumably, it creates additional affordances for metaphor construal; at the same time lower dynamicity in the cognitive construal produces higher gaze costs in both groups. The study shows that irrespective of the metaphor type, several construal patterns produce consistent gaze costs, either increased or decreased.
Measurement of ion and electron drift velocity and electronic attachment in air for ionization chambers

Air-ionization chambers have been used in radiotherapy and particle therapy for decades. However, fundamental parameters in action in the detector responses are sparsely studied. In this work we aimed to measure the electronic attachment, electrons and ions mobilities of an ionization chamber (IC) in air. The main idea is to extract these from the actual response of the IC to a single ionizing particle in order to insure that they were measured in the same condition they are to be used while neglecting undesired phenomena: recombination and space charge effect. The non-standard signal shape analysis performed here were also confronted to a more standard drift chamber measurements using time-of-flight. It was found that both detectors displayed compatible results concerning positive and negative ions drift velocities where literature data is well spread out. In the same time, electron attachment measurements sit in the middle of known measurements while electron drift velocities seemed to show an offset compared to the well known and modeled data.
Usnic Acid-Loaded Polymeric Micelles: An Optimal Migrastatic-Acting Formulation in Human SH-SY5Y Neuroblastoma Cells

Usnic acid (UA) is one of the most abundant and common metabolites of lichens, known for its numerous pharmacological properties. Nevertheless, it presents some criticalities that severely limit its use in therapy: poor solubility in water and significant hepatotoxicity. Soluplus and Solutol HS15 and D-α-Tocopherol polyethylene glycol 1000 succinate (TPGS) were employed to develop polymeric micelles (UA–PM). The chemical and physical properties of the system were characterized, including the size, homogeneity, zeta potential, critical micellar concentration (CMC), encapsulation efficiency (EE%), and in vitro release. The freeze-drying process was considered to prevent agglomeration and improve the stability of the formulation. The stability of the micelles and the freeze-dried product (UA–PML) was also evaluated. The anti-migratory activity of UA and UA–PM was evaluated in human neuroblastoma SH-SY5Y cells using the wound healing assay. Their effect on the activity of metalloproteinases (MMP)-2/9 involved in the migration process of cells was verified by gelatin zymography. The optimized UA–PM contained Soluplus, Solutol HS15, and TPGS in a 1:4:0.5 weight ratio and increased the aqueous solubility to about 150-fold solubilized, solubilizing 0.5 mg/mL of UA. UA–PM has a small size (45.39 ± 0.31 nm), a polydispersity index (PDI) of 0.26 ± 0.01, and an EE% of 82.13 ± 5.57%. The colloidal dispersion was stable only for 9 days at 4 °C, while the freeze-drying process improved the stability for up to 30 days. UA was released for a prolonged period during the in vitro release study. The in vitro cell-based experiments showed that UA–PM (0.2 µg/mL) inhibited SH-SY5Y cell migration and the gelatinolytic activity of MMP-2/9 in culture media, while free UA at the same concentration exerted no biological activity. This study demonstrates that polymeric micelles are an excellent formulation for UA to manifest inhibitory action on neuroblastoma cell migration.
Role of the Hedgehog Pathway and CAXII in Controlling Melanoma Cell Migration and Invasion in Hypoxia

Simple Summary Malignant melanoma is the leading cause of death among skin cancer patients due to its tendency to metastasize. Hypoxia, which is a common feature of the tumor microenvironment, as well as different alterations at the molecular level, may affect melanoma aggressiveness. The aims and the objectives of this work were to investigate whether and how the Hedgehog pathway and CAXII may control malignant melanoma cell migration and invasiveness either in normoxic or hypoxic conditions. To this end we evaluated the migratory and invasive capabilities of SK-MEL-28 and A375 cell lines, where the hedgehog pathways and CAXII were inhibited by short interfering RNA. Our results indicate that SMO and GLI1 silencing caused the downregulation of CAXII expression. Furthermore, the Hedgehog pathway and CAXII inhibition, resulted in impaired melanoma cell migration and invasion either under normoxic or hypoxic conditions. The fact that CAXII and the Hedgehog pathway are relevant in melanoma cell invasion may be exploited to discover novel and promising therapeutical targets for melanoma clinical management. Abstract Background: Malignant melanoma is the leading cause of death among skin cancer patients due to its tendency to metastasize. Alterations at the molecular level are often evident, which is why melanoma biology has garnered increasing interest. The hedgehog (Hh) pathway, which is essential for embryonic development, is aberrantly re-activated in melanoma and may represent a promising therapeutic target. In addition, carbonic anhydrase XII (CAXII) represents a poor prognostic target for hypoxic tumors, such as melanoma, and is involved in cell migration. Thus, we decided to investigate whether and how the Hh pathway and CAXII may control melanoma cell migration and invasiveness. Methods: The migratory and invasive capabilities of SK-MEL-28 and A375 cell lines, either un-transfected or transiently transfected with Smoothened (SMO), GLI1, or CAXII siRNA, were studied under normoxic or hypoxic conditions. Results: For the first time, we showed that SMO and GLI1 silencing resulted in the downregulation of CAXII expression in both moderately and highly invasive melanoma cells under hypoxia. The Hh pathway as well as CAXII inhibition by siRNA resulted in impaired malignant melanoma migration and invasion. Conclusion: Our results suggest that CAXII and the Hh pathway are relevant in melanoma invasion and may be novel and promising therapeutical targets for melanoma clinical management.
NEAR-INFRARED SPECTROSCOPY OF FIVE BLUE COMPACT DWARF GALAXIES: II Zw 40, Mrk 71, Mrk 930, Mrk 996, and SBS 0335−052E

We present near-infrared (NIR) spectroscopic observations of five blue compact dwarf (BCD) galaxies, II Zw 40, Mrk 71, Mrk 930, Mrk 996, and SBS 0335–052E. The NIR spectra which cover the 0.90–2.40 μm wavelength range show hydrogen, molecular hydrogen, helium, sulfur, and iron emission lines. The NIR data for all BCDs have been supplemented by optical spectra. We found the extinction coefficient in all BCDs to be very similar in both the optical and NIR ranges. The NIR hydrogen emission lines do not reveal more star formation than seen in the optical. The same conclusion is reached from Spitzer data concerning the mid-infrared (MIR) emission lines. This implies that emission line spectra of low-metallicity BCDs in the ∼0.36–25 μm wavelength range are emitted by relatively transparent ionized gas. The large extinction derived from the MIR continuum emission in some BCDs implies that the latter arises not from the visible H ii regions themselves, but from locations outside these H ii regions. The H2 emission line fluxes can be accounted for by fluorescence. CLOUDY stellar photoinization models of all BCDs reproduce well the fluxes of most of the observed optical and NIR emission lines, except in Mrk 930 where shock ionization is needed to account for the [Fe ii] emission lines. However, some contribution of shock ionization at the level of ≲10% that of stellar ionization is required to reproduce the observed fluxes of high ionization species, such as He ii λ0. 469 μm in the optical range and [O iv] λ25. 89 μm in the MIR range.
Algebraic Observability of Linear Differential-Algebraic Systems with Delay

: The paper deals with the problem of algebraic observability for linear diﬀerential-algebraic systems with delay. For such systems, we present the observability matrix. By algebraic properties of the matrix we deﬁne some concepts of observability. We give necessary and suﬃcient conditions of these algebraic observabilities. We prove relations between these types of observabilities along with spectral observability. Practical veriﬁability of the conditions is demonstrated on several examples.
EVIDENCE FOR A ∼300 MEGAPARSEC SCALE UNDER-DENSITY IN THE LOCAL GALAXY DISTRIBUTION

Galaxy counts and recent measurements of the luminosity density in the near-infrared have indicated the possibility that the local universe may be under-dense on scales of several hundred megaparsecs. The presence of a large-scale under-density in the local universe could introduce significant biases into the interpretation of cosmological observables, and, in particular, into the inferred effects of dark energy on the expansion rate. Here we measure the K-band luminosity density as a function of redshift to test for such a local under-density. For our primary sample in this study, we select galaxies from the UKIDSS Large Area Survey and use spectroscopy from the Sloan Digital Sky Survey (SDSS), the Two-degree Field Galaxy Redshift Survey, the Galaxy And Mass Assembly Survey (GAMA), and other redshift surveys to generate a K-selected catalog of ∼35, 000 galaxies that is ∼95% spectroscopically complete at KAB < 16.3 (KAB < 17 in the GAMA fields). To complement this sample at low redshifts, we also analyze a K-selected sample from the 2M++ catalog, which combines Two Micron All Sky Survey (2MASS) photometry with redshifts from the 2MASS redshift survey, the Six-degree Field Galaxy Redshift Survey, and the SDSS. The combination of these samples allows for a detailed measurement of the K-band luminosity density as a function of distance over the redshift range 0.01 < z < 0.2 (radial distances D ∼ 50–800 Mpc). We find that the overall shape of the z = 0 rest-frame K-band luminosity function (M*–5log (h70) = −22.15 ± 0.04 and α = −1.02 ± 0.03) appears to be relatively constant as a function of environment and distance from us. We find a local (z < 0.07, D < 300 Mpc) luminosity density that is in good agreement with previous studies. Beyond z ∼ 0.07, we detect a rising luminosity density that reaches a value of roughly ∼1.5 times higher than that measured locally at z > 0.1. This suggests that the stellar mass density as a function of distance follows a similar trend. Assuming that luminous matter traces the underlying dark matter distribution, this implies that the local mass density of the universe may be lower than the global mass density on a scale and amplitude sufficient to introduce significant biases into the determination of basic cosmological observables. An under-density of roughly this scale and amplitude could resolve the apparent tension between direct measurements of the Hubble constant and those inferred by Planck.
SUSY implications from WIMP annihilation into scalars at the Galactic Center

An excess in $\gamma$-rays emanating from the galactic centre has recently been observed in the Fermi-LAT data. We investigate the new exciting possibility of fitting the signal spectrum by dark matter annihilating dominantly to a Higgs-pseudoscalar pair. We show that the fit to the $\gamma$-ray excess for the Higgs-pseudoscalar channel can be just as good as for annihilation into bottom-quark pairs. This channel arises naturally in a full model such as the next-to-minimal supersymmetric Standard Model (NMSSM) and we find regions where dark matter relic density, the $\gamma$-ray signal and other experimental constraints, can all be satisfied simultaneously. Annihilation into scalar pairs allows for the possibility of detecting the Higgs or pseudoscalar decay into two photons, providing a smoking-gun signal of the model.
The ongoing impact of the Covid-19 pandemic on endometriosis patients: A survey of 1,089 UK patients

Background The impact of Covid-19 on endometriosis patients is under-researched. Endometriosis has significant psychosocial effects on patients. Moreover, the mainstay of diagnosis and treatment of endometriosis is elective surgery, impacted as a result of healthcare strain. Objective To better understand the effect of the Covid-19 pandemic on endometriosis patients Materials and Methods An online survey sent to adult UK endometriosis patients between 27th August and 15th September 2021. The study received HRA and HCRW research ethic committee approval. Main outcome measures Effects of the Covid-19 pandemic on endometriosis symptoms and surgery Results We received 1,089 survey responses. Respondents had a median age of 34, and 82.0% of respondents were white British. 18.8% of respondents reported a previous positive Covid-19 PCR test. 84.6% of patients had been double vaccinated at time of response. 20 patients reported Covid-related hospital admission, with 1 requiring intubation. Large numbers of patients (31.4-55.2%) reported worsening of endometriosis symptoms during the pandemic. 69.2% of respondents reported worsening of associated mental health symptoms. Whilst 44% of respondents had elective endometriosis surgery planned, the majority of operations were disrupted, and 18.7% of total respondents did not have a new surgery date. Conclusions More research and support are needed for endometriosis patients as they wait longer for surgery. A holistic approach, encompassing mental health needs, may be particularly beneficial for patients. What is new? This is the first survey examining the effects of Covid-19 on endometriosis patients including data beyond January 2021.
A UNIFORM ASTEROSEISMIC ANALYSIS OF 22 SOLAR-TYPE STARS OBSERVED BY KEPLER

Asteroseismology with the Kepler space telescope is providing not only an improved characterization of exoplanets and their host stars, but also a new window on stellar structure and evolution for the large sample of solar-type stars in the field. We perform a uniform analysis of 22 of the brightest asteroseismic targets with the highest signal-to-noise ratio observed for 1 month each during the first year of the mission, and we quantify the precision and relative accuracy of asteroseismic determinations of the stellar radius, mass, and age that are possible using various methods. We present the properties of each star in the sample derived from an automated analysis of the individual oscillation frequencies and other observational constraints using the Asteroseismic Modeling Portal (AMP), and we compare them to the results of model-grid-based methods that fit the global oscillation properties. We find that fitting the individual frequencies typically yields asteroseismic radii and masses to ∼1% precision, and ages to ∼2.5% precision (respectively, 2, 5, and 8 times better than fitting the global oscillation properties). The absolute level of agreement between the results from different approaches is also encouraging, with model-grid-based methods yielding slightly smaller estimates of the radius and mass and slightly older values for the stellar age relative to AMP, which computes a large number of dedicated models for each star. The sample of targets for which this type of analysis is possible will grow as longer data sets are obtained during the remainder of the mission.
Association of Patients’ Epidemiological Characteristics and Comorbidities with Severity and Related Mortality Risk of SARS-CoV-2 Infection: Results of an Umbrella Systematic Review and Meta-Analysis

The objective of this study was to assess the association between patients’ epidemiological characteristics and comorbidities with SARS-CoV-2 infection severity and related mortality risk. An umbrella systematic review, including a meta-analysis examining the association between patients’ underlying conditions and severity (defined as need for hospitalization) and mortality of COVID-19, was performed. Studies were included if they reported pooled risk estimates of at least three underlying determinants for hospitalization, critical disease (ICU admission, mechanical ventilation), and hospital mortality in patients diagnosed with SARS-CoV-2 infection. Evidence was summarized as pooled odds ratios (pOR) for disease outcomes with 95% confidence intervals (95% CI). Sixteen systematic reviews investigating the possible associations of comorbidities with severity or death from COVID-19 disease were included. Hospitalization was associated with age > 60 years (pOR 3.50; 95% CI 2.97–4.36), smoking habit (pOR 3.50; 95% CI 2.97–4.36), and chronic pulmonary disease (pOR 2.94; 95% CI 2.14–4.04). Chronic pulmonary disease (pOR 2.82; 95% CI 1.92–4.14), cerebrovascular disease (pOR 2.74; 95% CI 1.59–4.74), and cardiovascular disease (pOR 2.44; 95% CI 1.97–3.01) were likely to be associated with increased risk of critical COVID-19. The highest risk of mortality was associated with cardiovascular disease (pOR 3.59; 95% CI 2.83–4.56), cerebrovascular disease (pOR 3.11; 95% CI 2.35–4.11), and chronic renal disease (pOR 3.02; 95% CI 2.61–3.49). In conclusion, this umbrella systematic review provides a comprehensive summary of meta-analyses examining the impact of patients’ characteristics on COVID-19 outcomes. Elderly patients and those cardiovascular, cerebrovascular, and chronic renal disease should be prioritized for pre-exposure and post-exposure prophylaxis and early treatment.
Household Composition and the Early Academic Performance of Latinx Children of Immigrants

ABSTRACT Household composition has diversified and encompasses the number of parents and the types of extended relatives in homes with implications for a child’s development. Yet, few studies have included Latinx children of immigrant parents. To fill this gap, I draw upon the Early Childhood Longitudinal Study, 2011-cohort to analyze the household composition and academic performance of Latinx children of immigrant parents and Latinx children of U.S.-born parents from kindergarten through fifth grade. I use an ecological framework to situate household composition as a microsystem component. Results indicated that Latinx children of immigrant parents were less likely to have lived with a single parent and more likely to have lived with horizontal relatives, like aunts or uncles, compared to Latinx children of U.S.-born parents. However, they were as likely as Latinx children of U.S.-born parents to have lived with grandparents or with grandparents and other extended relatives. Structural factors largely shaped household composition. Importantly, household composition states did not compensate for the academic disparities in math and reading between Latinx children of immigrant parents and Latinx children of U.S.-born parents. However, the presence of extended relatives did have a partial effect in some household composition states.
Characterization of ‘Cabernet Sauvignon’ pomace extracts and evaluation of antifungal potential of Alternaria sp. and Fusarium sp.

This study was conducted to capitalize on the waste produced by the vinification process which proved to be important sources of bioactive compounds with significant antifungal properties. ‘Cabernet Sauvignon’ grape pomace extracts were characterized in terms of total polyphenol content, antioxidant potential, but also evaluated in terms of antifungal effect against phytopathogenic fungi (Fusarium sp. and Alternaria sp.). The isolates used in this study were grown on three potato-dextrose-agar culture media, Czapek Dox and Malt-Agar. The highest amount of polyphenols was determined from the extract obtained by the microwave-assisted method (42.76 mg/g GAE), followed by the extract obtained by maceration (30.37 mg/g GAE). The lowest amount was obtained by the ultrasound-assisted method (15.06 mg/g GAE). However, the highest antioxidant activity was determined in the macerated extract, TEAC = 0.0523. The results of in vitro tests clearly indicated a high inhibitory percentage on the mycelium growth rate and, respectively, a significant decrease in spore germination power in Fusarium sp. (91.56%). However, for the pathogen Alternaria sp. further studies are needed to correctly validate the percentage of inhibition, as alcohol has been shown to have a negative effect on it.