Miracle-dz/UniFAR-FTUs huggingface dataset:
The Self-Administered Use of Complementary and Alternative Medicine (CAM) Supplements and Antioxidants in Cancer Therapy and the Critical Role of Nrf-2—A Systematic Review

Complementary and alternative medicine (CAM) supplements are widely used by cancer patients. Dietary supplements, vitamins and minerals, herbal remedies, and antioxidants are especially popular. In a systematic literature review, 37 studies, each including more than 1000 participants, on CAM, dietary supplement, and vitamin use among cancer patients were identified. Accordingly, cancer patients use antioxidants such as vitamin C (from 2.6% (United Kingdom) to 41.6% (United States)) and vitamin E (from 2.9% (China) to 48% (United States)). Dietary supplements and vitamins are taken for different reasons, but often during conventional cancer treatment involving chemotherapy or radiotherapy and in a self-decided manner without seeking medical advice from healthcare professionals. Drug–drug interactions with dietary supplements or vitamins involving multiple signaling pathways are well described. Since most of the anticancer drugs generate reactive oxygen species (ROS), an adaptive stress response of healthy and malignant cells, mainly driven by the Nrf-2-Keap I network, can be observed. On the one hand, healthy cells should be protected from ROS-overproducing chemotherapy and radiotherapy; on the other hand, ROS production in cancer cells is a “desirable side effect” during anticancer drug treatment. We here describe the paradoxical use of antioxidants and supplements during cancer therapy, possible interactions with anticancer drugs, and the involvement of the Nrf-2 transcription factor.
Extraskeletal Ewing's Sarcoma With Vertebral Metastasis: A Case Report

Ewing's sarcoma (ES) is the second most common osseous tumor in young patients after osteosarcoma. All primitive neuroectodermal tumors (PNET) and Askin tumors are members of Ewing's sarcoma family of tumors (ESFT), which all have aberrant translocations between the 11th and 22nd chromosomes. Only one in five cases of Ewing's sarcoma occurs as extraskeletal. In this report, we describe a young female with a palpable lump on her spine who presented with paravertebral and thoracic extraskeletal Ewing's sarcoma (EES). Over six months, the swelling gradually increased in size, and the patient reported episodes of episodic pain and fever. Examining the swelling, a non-reducible, non-tender ovoid lump measuring approximately 8 cm x 5 cm was found to have smooth margins and be slightly mobile. The use of magnetic resonance imaging (MRI) helped diagnose, plan surgical resections, assess neoadjuvant chemotherapy effectiveness, and detect local recurrences and metastatic spread of the tumor. The differential diagnosis of EES included embryonal rhabdomyosarcoma and lymphoma. The use of immunohistochemical markers further differentiated the diagnoses. In conclusion, it should be noted that EES, though rare, should be considered when evaluating soft tissue lumps of neoplastic characteristics, in children or adolescents. Considering the poor prognosis of this disease, early detection is essential. The MRI plays a vital role in diagnosing cancer, staging it locally, assessing response to neoadjuvant therapy, and identifying local recurrences and metastases.
The Type Ic Hypernova SN 2002ap

Photometric and spectroscopic data of the energetic Type Ic supernova (SN) 2002ap are presented, and the properties of the SN are investigated through models of its spectral evolution and its light curve. The SN is spectroscopically similar to the "hypernova" SN 1997ef. However, its kinetic energy [~(4-10) × 1051 ergs] and the mass ejected (2.5-5 M☉) are smaller, resulting in a faster evolving light curve. The SN synthesized ~0.07 M☉ of 56Ni, and its peak luminosity was similar to that of normal SNe. Brightness alone should not be used to define a hypernova, whose defining character, namely very broad spectral features, is the result of high kinetic energy. The likely main-sequence mass of the progenitor star was 20-25 M☉, which is also lower than that of both hypernovae SN 1997ef and SN 1998bw. SN 2002ap appears to lie at the low-energy and low-mass end of the hypernova sequence as it is known so far. Observations of the nebular spectrum, which is expected to dominate by the summer of 2002, are necessary to confirm these values.
Integrated management of Cymbidium mosaic disease in commercial Dendrobium orchids using root endophytic fungi Piriformospora indica

Abstract Commercial orchid industry is a lucrative business worldwide. New varieties and hybrids are being developed hastily in a race to keep up with the ever-growing demand for novelty and quality of flowers. The orchid exports contribute a lion’s share of the worldwide cutflower and plant export industry. Cymbidium mosaic virus (CymMV) is a major threat to the orchid industry as it is mechanically transmissible and quarantined in many countries. This study evaluates the effectiveness of the novel root endophyte Piriformospora indica (syn. Serendipita indica) when integrated with commonly used antiviral chemicals and defense inducing compounds to effectively control CymMV in commercially cultivated Dendrobium orchids. The effectiveness of each treatment was assessed by observing the reduction of CymMV titer using DAC-ELISA. Plants treated with Virus Ex @1.0 ml L−1foliar (antiviral formulation) and combination treatment with P. indica root inoculation and Virus Ex −1 ml L−1foliar spray showed significantly lower viral titer than other treatments. This suggests that P. indica can be used as an effective and easy treatment method that can be adopted by farmers and orchid growers in combination with regular antiviral formulations to control of CymMV.
Invisible Higgs Decay at the LHeC

The possibility that the 125 GeV Higgs boson may decay into invisible non-standard-model (nonSM) particles is theoretically and phenomenologically intriguing. In this letter we investigate the sensitivity of the Large Hadron Electron Collider (LHeC) to an invisibly decaying Higgs, in its proposed high luminosity running mode. We focus on the neutral current Higgs production channel which offers more kinematical handles than its charged current counterpart. The signal contains one electron, one jet and large missing energy. With a cut-based parton level analysis, we estimate that if the hZZ coupling is at its standard model (SM) value, then assuming an integrated luminosity of 1 ab−1 the LHeC with the proposed 60 GeV electron beam (with −0.9 polarization) and 7 TeV proton beam is capable of probing Br(h → / ET ) = 6% at 2σ level. Good lepton veto performance (especially hadronic τ veto) in the forward region is crucial to the suppression of the dominant Wje background. We also explicitly point out the important role that may be played by the LHeC in probing a wide class of exotic Higgs decay processes and emphasize the general function of lepton-hadron colliders in precision study of new resonances after their discovery in hadron-hadron collisions.
Ultrasound-Guided Quadratus Lumborum Block Versus Caudal Block for Pain Relief in Children Undergoing Lower Abdominal Surgeries: A Randomized, Double-Blind Comparative Study

Background The quadratus lumborum (QL) block, also known as the abdominal truncal block, was developed to provide visceral and somatic analgesia during abdominal procedures. Objectives This study aimed to assess pain alleviation, the incidence of complications in lower abdominal procedures, and hemodynamic stability between the caudal block and ultrasound-guided QL block. Methods Fifty-two patients aged 1 to 7 years old from both genders scheduled for unilateral lower abdominal surgery were randomly assigned to 2 study groups: group QL, unilateral QL block (n = 26), and group C, caudal block (n = 26). In group C, children received caudal block. In group QL, an ultrasound-guided QL block was performed. The time to first rescue analgesia was evaluated as a primary outcome. The quality of analgesia was determined using the face, legs, activity, cry, consolability scale (FLACC scale), hemodynamic parameters, and incidence of complications because hemodynamic instability was recorded under ultrasound guidance. Signs of local anesthetics toxicity and the parents’ satisfaction were secondary outcomes. Results The time until the first demand for analgesia postoperatively was statistically longer in group QL compared to group C. A non-significant difference was observed between the 2 groups (P > 0.05) regarding age, weight, gender, duration of surgery, type of surgery, FLACC scale, and hemodynamics (SBP, systolic blood pressure), except at 30 minutes, which was significant in QL block. Also, a non-significant difference was observed in the severity of postoperative pain up to 1 day postoperatively. Group QL showed more satisfaction than group C. No intraoperative complications were detected. Conclusions Compared to caudal block, QL block produced sustained and adequate analgesia time postoperatively, with higher satisfaction.
Statistics of the fractional polarisation of extragalactic dusty sources in Planck HFI maps

We estimate the average fractional polarisation at 143, 217 and 353 GHz of a sample of 4697 extragalactic dusty sources by applying stacking technique. The sample is selected from the second version of the Planck Catalogue of Compact Sources at 857 GHz, avoiding the region inside the Planck Galactic mask (fsky ~ 60 per cent). We recover values for the mean fractional polarisation at 217 and 353 GHz of (3.10 \pm 0.75) per cent and (3.65 \pm 0.66) per cent, respectively, whereas at 143 GHz we give a tentative value of (3.52 \pm 2.48) per cent. We discuss the possible origin of the measured polarisation, comparing our new estimates with those previously obtained from a sample of radio sources. We test different distribution functions and we conclude that the fractional polarisation of dusty sources is well described by a log-normal distribution, as determined in the radio band studies. For this distribution we estimate {\mu}_{217GHz} = 0.3 \pm 0.5 (that would correspond to a median fractional polarisation of {\Pi}_{med} = (1.3 \pm 0.7) per cent) and {\mu}_{353GHz} = 0.7 \pm 0.4 ({\Pi}_{med} = (2.0 \pm 0.8) per cent), {\sigma}_{217GHz} = 1.3 \pm 0.2 and {\sigma}_{353GHz} = 1.1 \pm 0.2. With these values we estimate the source number counts in polarisation and the contribution given by these sources to the CMB B-mode angular power spectrum at 217, 353, 600 and 800 GHz. We conclude that extragalactic dusty sources might be an important contaminant for the primordial B-mode at frequencies > 217 GHz.
Clinical study of outcome of operative management of locally advanced breast carcinoma after neoadjuvant chemotherapy at tertiary care hospital

Background: Locally advanced diseased of the breast is characterised clinically by features suggesting infiltration of the skin or chest wall by tumour or matted involved axillary nodes (AJCC-stage III). Successful reduction in the size of the tumor is associated with increased rate of operability i.e., modified radical mastectomy or breast conserving therapy (BCT). The aim of this study is to assess outcome of surgery in management of locally advanced breast carcinoma (LABC) after neoadjuvant chemotherapy.Methods: It is an observational retrospective study of 40 cases of LABC admitted at general surgery department.Results: The response to neoadjuvant chemotherapy was seen in 92.5% cases- with complete response in 10% cases (4 patients) and partial response in 82.5% (33 patients). No response was observed in 7.5% cases (3 patients) after 4 cycles of neoadjuvant chemotherapy. All patients were subjected to surgery after chemotherapy, out of whom 02 patients (5%) have surgical site infection and flap necrosis in 01 patient (2.5%) and no mortality; 02 patients subjected to toilet mastectomy without neoadjuvant chemotherapy resulted in 01 recurrence within 6 months of completion of adjuvant therapy and 01 death postoperatively.Conclusions: Majority of patients were subjected to neoadjuvant chemotherapy responded partially to it. Overall observations suggested that most of the LABC responds to neoadjuvant chemotherapy with minimum post-operative morbidity and mortality.
Physical Properties of the First Quasars

Abstract Since the beginning of the new millennium, more than 100 z ~ 6 quasars have been discovered through several surveys and followed-up with multi-wavelength observations. These data provided a large amounts of information on the growth of supermassive black holes at the early epochs, the properties of quasar host galaxies and the joint formation and evolution of these massive systems. We review the properties of the highest z quasars known so far, especially focussing on some of the most recent results obtained in (sub-)millimetre bands. We discuss key observational challenges and open issues in theoretical models and highlight possible new strategies to improve our understanding of the galaxy black hole formation and evolution in the early Universe.
PALEOGEOGRAPHY AND HIGH-PRECISION GEOCHRONOLOGY OF THE NEOARCHEAN FORTESCUE GROUP, PILBARA, WESTERN AUSTRALIA

While rates of Phanerozoic plate movements and magnetic field reversals have been well studied, little is known about such phenomena on early Earth. The ca. 2.8 – 2.7 Ga Fortescue Group on the Pilbara craton in Western Australia has been recognized as a well-preserved sequence of Archean rift volcanics thought to derive from a flood basalt province, and may have been moving rapidly across the globe at two different intervals in its depositional history. We present the results of a magnetostratigraphic study integrated with high-precision U-Pb ID-TIMS geochronology aiming to quantify rates of cratonic motion and provide a continuous time series for changes in Pilbara paleogeography during these two rapid intervals, at ~2.77 and 2.72 Ga. We provide six new or updated high-quality paleomagnetic poles for inclusion in databases tracking Precambrian cratonic motion. During the craton ’ s largest geographic displacement at ~2.77 Ga, we resolve a minimum drift rate of 23 ± 20 cm/a if there was substantial rotation of the Pilbara craton along with translational motion, and a more rapid minimum estimate of 64 ± 23 cm/a if the motion was dominated by translation; these estimates exceed both Mesoarchean and most modern rates of plate motion. We provide a new high-precision U-Pb zircon age of 2721.23 ± 0.88/0.88/6.9 Ma for the Tumbiana Formation stromatolite colony, which developed as the Pilbara craton drifted from 51.5 ± 7.0 ◦ to 32.1 ± 5.7 ◦ paleolatitude. Although the Fortescue Group has been considered an early prototype of large igneous provinces, it was emplaced over a longer duration than its Phanerozoic counterparts and does not fit at least one definition of a large igneous province (LIP). But as a potential prototype of LIP magmatism, the Fortescue succession chronicles eruptive dynamics, rapid paleogeographic changes, and a series of robustly determined magnetic field reversals during the Neoarchean.
Lectin histochemistry of the olfactory mucosa of Korean native cattle, Bos taurus coreanae

Background The olfactory mucosa (OM) is crucial for odorant perception in the main olfactory system. The terminal carbohydrates of glycoconjugates influence chemoreception in the olfactory epithelium (OE). Objectives The histological characteristics and glycoconjugate composition of the OM of Korean native cattle (Hanwoo, Bos taurus coreae) were examined to characterize their morphology and possible functions during postnatal development. Methods The OM of neonate and adult Korean native cattle was evaluated using histological, immunohistochemical, and lectin histochemical methods. Results Histologically, the OM in both neonates and adults consists of the olfactory epithelium and the lamina propria. Additionally, using periodic acid Schiff and Alcian blue (pH 2.5), the mucus specificity of the Bowman’s gland duct and acini in the lamina propria was determined. Immunohistochemistry demonstrated that mature and immature olfactory sensory neurons of OEs express the olfactory marker protein and growth associated protein-43, respectively. Lectin histochemistry indicated that numerous glycoconjugates, including as N-acetylglucosamine, mannose, galactose, N-acetylgalactosamine, complex type N-glycan, and fucose groups, were expressed at varied levels in the different cell types in the OMs of neonates and adults at varying levels. According to our observations, the cattle possessed a well-developed olfactory system, and the expression patterns of glycoconjugates in neonatal and adult OMs varied considerably. Conclusions This is the first study to describe the morphological assessment of the OM of Korean native cattle with a focus on lectin histochemistry. The findings suggest that glycoconjugates may play a role in olfactory chemoreception, and that their labeling properties may be closely related to OM development and maturity.
Unified framework for magic state distillation and multiqubit gate synthesis with reduced resource cost

The standard approach to fault-tolerant quantum computation is to store information in a quantum error correction code, such as the surface code, and process information using a strategy that can be summarized as distill then synthesize. In the distill step, one performs several rounds of distillation to create high-fidelity logical qubits in a magic state. Each such magic state provides one good $T$ gate. In the synthesize step, one seeks the optimal decomposition of an algorithm into a sequence of many $T$ gates interleaved with Clifford gates. This gate-synthesis problem is well understood for multiqubit gates that do not use any Hadamards. We present an in-depth analysis of a unified framework that realizes one round of distillation and multiqubit gate synthesis in a single step. We call these synthillation protocols, and show they lead to a large reduction in resource overheads. This is because synthillation can implement a general class of circuits using the same number of $T$ states as gate synthesis, yet with the benefit of quadratic error suppression. This general class includes all circuits primarily dominated by control-control-$Z$ gates, such as adders and modular exponentiation routines used in Shor's algorithm. Therefore, synthillation removes the need for a costly round of magic state distillation. We also present several additional results on the multiqubit gate-synthesis problem. We provide an efficient algorithm for synthesizing unitaries with the same worst-case resource scaling as optimal solutions. For the special case of synthesizing controlled unitaries, our techniques are not just efficient but exactly optimal. We observe that the gate-synthesis cost, measured by $T$ count, is often strictly subadditive. Numerous explicit applications of our techniques are also presented.
Scattering Study of Pulsars below 100 MHz Using LWA1

Interstellar scattering causes pulsar profiles to grow asymmetrically, thus affecting the pulsar timing residuals, and is strongest at lower frequencies. Different interstellar medium models predict different frequency (ν) and dispersion measure (DM) dependencies for the scattering timescale τsc. For Gaussian inhomogeneity the expected scaling relation is , while for a Kolmogorov distribution of irregularities, the expected relation is . Previous scattering studies showed a wide range of scattering index across all ranges of DM. A scattering index below 4 is believed to be either due to limitations of the underlying assumptions of the thin-screen model or an anisotropic scattering mechanism. We present a study of scattering for seven nearby pulsars (DM < 50 pc cm−3) observed at low frequencies (10–88 MHz), using the first station of the Long Wavelength Array. We examine the scattering spectral index and DM variation over a period of about three years. The results yield insights into the small-scale structure of the interstellar medium, as well as the applicability of the thin-screen model for low-DM pulsars.
UAV Fault Detection Methods, State-of-the-Art

The continual expansion of the range of applications for unmanned aerial vehicles (UAVs) is resulting in the development of more and more sophisticated systems. The greater the complexity of the UAV, the greater the likelihood that a component will fail. Due to the fact that drones often operate in close proximity to humans, the reliability of flying robots, which directly affects the level of safety, is becoming more important. This review article presents recent research works on fault detection on unmanned flying systems. They include papers published between January 2016 and August 2022. Web of Science and Google Scholar databases were used to search for articles. Terminology related to fault detection of unmanned aerial vehicles was used as keywords. The articles were analyzed, each paper was briefly summarized and the most important details concerning each of the described articles were summarized in the table.
Variational Quantum Monte Carlo Method with a Neural-Network Ansatz for Open Quantum Systems.

The possibility to simulate the properties of many-body open quantum systems with a large number of degrees of freedom (d.o.f.) is the premise to the solution of several outstanding problems in quantum science and quantum information. The challenge posed by this task lies in the complexity of the density matrix increasing exponentially with the system size. Here, we develop a variational method to efficiently simulate the nonequilibrium steady state of Markovian open quantum systems based on variational Monte Carlo methods and on a neural network representation of the density matrix. Thanks to the stochastic reconfiguration scheme, the application of the variational principle is translated into the actual integration of the quantum master equation. We test the effectiveness of the method by modeling the two-dimensional dissipative XYZ spin model on a lattice.
The Influence Of Financial Performance, Macroeconomic Indicators And Systemic Risk On Manufacturing Sector Sharia Share Return

The purpose of this study is to examine and analyze the effect of financial performance as measured using Return On Assets (ROA), Current Ratio (CR) and Earning Per Share (EPS), macroeconomic indicators using the BI rate, exchange rate and inflation as well as adding systematic risk as the intervening variable on sharia stock returns in the manufacturing sector on the Indonesian Sharia Stock Index (ISSI). The research sample was 51 companies with a range of observations from 2016 to 2020, using the Structural Equation Modeling (SEM) method and IBM AMOS (Analysis of Structural Moment) V.22 software for testing the available data. The findings of the direct test results show that financial performance and systematic risk have an effect on Islamic stock returns, while macroeconomic indicators have no effect. The test results through the intervening variable found that financial performance had an effect, but macroeconomic indicators still had no effect on Islamic stock returns through systematic risk. Activities in the consumer goods industry and basic industry which have always been the main needs are the reason why issuers in the manufacturing sector at ISSI are not affected by changes in macroeconomic indicators.