Miracle-dz/UniFAR-FTUs huggingface dataset:
LPS , immune activation and liver abnormalities in HIV-HBV co-infected individuals on HBV-active combination antiretroviral therapy

We investigated the relationship between microbial translocation, immune activation and liver disease in HIV-HBV co-infection. Lipopolysaccharide (LPS), soluble (s)CD14, CXCL10 and CCL-2 were elevated in HIV-HBV co-infection and declined following HBVactive combination antiretroviral therapy (cART) but CXCL10 remained elevated. No markers were associated with liver disease severity on liver biopsy (n=96) but CXCL10, IL6, IL-10, TNFa and IFNg were all associated with elevated liver enzymes on HBV-active cART. Stimulation of hepatocyte cell lines in vitro with IFNg and LPS induced a profound synergistic increase in production of CXCL10. LPS may contribute to liver disease via stimulating persistent production of CXCL10. at U niersiti M aaya on M arch 1, 2014 http://jidrdjournals.org/ D ow nladed from
A Study of Histopathological Spectrum of Breast Lesions

Introduction: Breast cancer accounts for one-third of female cancers and approximately one-fourth of all malignancies. Malignancy not only poses a financial burden on the patient, their family, and society but also is responsible for emotional distress. Aim: This study aims to evaluate the frequency, age, gender, and histopathological features of breast carcinoma in a tertiary care hospital. Materials and Methods: This retrospective study was conducted in the Department of Pathology, Coimbatore Medical College and Hospital, from January 2017 to October 2018. Tissue for hematoxylin and eosin (H and E) sections was fixed in 10% formalin and subjected to routine paraffin-embedded processing and stained with H and E. The histopathological features were noted, and the tumors were diagnosed based on the WHO classification and graded adopting modified Bloom–Richardson grading system. Results: Of the 120 specimens received, 116 specimens belonged to female patients (97%). The peak age of the occurrence of breast masses was in the 3rd decade (32% occurrence). Both malignant and non-malignant lesions were present in the specimens. Among the 98 benign lesions, 45 cases were of fibroadenoma (46%), 23 cases were of fibroadenosis (23%). Among the 22 malignant lesions, 17 cases were of infiltrative duct cell carcinoma (77%). Conclusion: The pattern of breast lesions provides valuable information concerning clinicopathological profile of breast lesions. The clinical diagnosis of a breast lump must be correlated with histopathological diagnosis for correct and adequate treatment of patient.
Small Molecule Rotamers Enable Simultaneous Optimization of Small Molecule and Protein Degrees of Freedom in R OSETTA L IGAND Docking

: We introduce small molecule rotamers into the rotamer search protocol used in R OSETTA to model small molecule flexibility in docking. Rosetta, a premier protein modeling suite, models side chain flexibility using discrete conformations observed in the Protein Data Bank (PDB). We mimic this concept and build small molecule rotamers based on conformations from the Cambridge Structural Database. We evaluate the small molecule rotamer generation protocol on a test set of 628 conformations, taken from the PDBBind database, of small molecules with ≤ 6 rotatable bonds. Our protocol generates ensembles in which the closest conformation on average is 0.45 ± 0.31 Å RMSD from the crystallized conformation. Furthermore, in two sets of docking benchmarks the native ligand position and conformation is found within the top 1 % of models by energy in 72% and 90% of all cases.
PREVALENCE & ANTIBACTERIAL RESISTANCE OF ESBLs AMONG PREGNANT WOMEN WITH UTI

Urinary tract infection (UTI) remains the common infections diagnosed in outpatients as well as in hospitalized patients. Worldwide data show that there is an increasing resistance among urinary tract pathogens to conventional drugs. Extended spectrum beta lactamases (ESBL) hydrolyse expanded spectrum cephalosporins like ceftazidime, cephotaxime which are used in the treatment of UTI. ESBL-producers are not easily detected by the routine disk diffusion susceptibility test, and this result in the failure of treatments due to inappropriate use of antibiotics. No information on ESBL producing organisms causing UTI is available from Tiruchirappalli, Tamil Nadu. Urinary isolates from symptomatic UTI cases attending or admitted to a hospital in Tiruchirappalli were identified by conventional methods. Antimicrobial susceptibility testing was done by Kirby Bauer’s disc diffusion method. Isolates resistant to cephotaxime were tested for ESBL production by double disc synergy test method. Of the 936 isolates, 236 (25.2%) were found to be ESBL producers. In the present study, a large number of uropathogens were found to be ESBL producers. Most of the ESBL producing isolates were multidrug resistant. Careful detection of ESBL production and antimicrobial susceptibility testing are necessary to avoid treatment failure in patients with UT
In vivo and in vitro study on the effect of Bacillus subtilis and its byproducts on Clostridium perfringens Type A

The objectives of this study were to screen the possible effects of B. subtilis and its soluble byproducts against C. perfringens, a causative agent of necrotic enteritis (NE) in chickens. The use of B. subtilis strain was found to be inactive in vitro against C. perfringens but its cell filtrate byproducts produced after growth of B. subtilis at 37°C with medium pH adjusted at 5.0, having inhibitory effect in the form of inhibitory zones; measured inhibition of 12 mm. The produced anticlostridial factor was not affected by heat treatment at 70, 100 or 121°C for 15 minutes. The study recorded the responses of broiler chickens to oral administration of C. perfringens and the possible antagonistic effects of B. subtilis and its cell-free filtrate byproducts in vivo. Results revealed that B. subtilis decreased the severity of intestinal necrotic lesions produced after oral inoculation of C. perfringens and the suggested anticlostridial effect was more clear when the cellfree filtrate produced by growing B. subtilis at 37°C with pH 5.0 was added to feed at a dose of 20 ml/kg of ration.
Assessing health-seeking behaviors of rural youth with type 1 diabetes through participatory action research

Type 1 diabetes mellitus (T1DM) occurs in 1 in 400 children and is most prevalent among rural, non-Hispanic whites (SEARCH, 2004, 2006; CDC, 2009). Growth and hormonal changes during puberty can cause insulin resistance, a reaction that makes it difficult for adolescents to maintain optimal glycemic control. Adolescents typically have poorer glycemic control with HgbA1c blood levels of 1% or higher than most adults, thus increasing complications. Poor glycemic control accounts for ten percent of the health care economic burden and short-term hospitalizations for 18 to 44 year-olds with diabetes, ranking fourth behind child birth, mental health issues, and injury (CDC, 2006; Kaiser, 2003). This study addresses following questions: “What does it mean to be healthy while living with a chronic disease such as T1DM in a rural community? ” “What are positive health-seeking behaviors an adolescent with T1DM needs to display to reflect health? ” What support do adolescents with T1DM require to be independent in successful management of their chronic illness? ” The study reveals that, for adolescents, “being healthy” means successfully completing medical tasks that prevent negative symptoms, “no nausea, and no shakiness. ” Positive health-seeking behaviors reflect these tasks: eating properly, exercising, checking blood sugars regularly, and using insulin appropriately. Adolescents
THE EFFECTS OF RESISTANCE EXERCISES AND YOGA ON THE LIFE QUALITY AND THE MUSCLE STRENGTH OF PATIENTS WITH KNEE OSTEOARTHRITIS: A SYSTEMIC REVIEW OF THE PREVIOUS LITERATURES

Background & Objective: Knee osteoarthritis (OA) is a common musculoskeletal disorder in elderly population leading to pain, disability, muscle weakness, and decreasing quality of life (QOL). The objective of the present study was to investigate the effects of land-based exercise therapy intervention on QOL and muscle strength in patients with knee OA in previous researches. Materials & Methods: English literature associated with the effects of land-based therapeutic exercise methods were extracted from Medline, PubMed, CINAHL, Medlib, IrMedex, Magiran, Spring link, Scopus, Cochrane, and Science Direct databases since 2000 to 2016. After applying inclusion and exclusion criteria, 11 articles remained to be reviewed. Results: There were 1200 patients (Mean ± Standard deviation 64.5±4.7 years of old) with knee OA in those eleven studies. Generally, two interventions were administrated for such patients including exercise therapy and Yoga. The most common treatment outcome measurements involved Western Ontario and McMaster Universities Arthritis Index (WOMAC), Short Form 36 (SF-36), and strength. Conclusion: Although it was impossible to compare the results of the eleven studies due to inconsistency in outcome measurements and their units to introduce the most effective therapeutic intervention for improvement of QOL in individuals with knee OA, the positive effect of land-based exercise therapy on signs and symptoms of such disorder was confirmed.
Action of the symmetric group on the free LAnKe: A CataLAnKe theorem

We initiate a study of the representation of the symmetric group on the multilinear component of an n-ary generalization of the free Lie algebra, which we call a free LAnKe. Our central result is that the representation of the symmetric group S2n−1 on the multilinear component of the free LAnKe with 2n − 1 generators is given by an irreducible representation whose dimension is the nth Catalan number. This leads to a more general result on eigenspaces of a certain linear operator. A decomposition, into irreducibles, of the representation of S3n−2 on the multilinear component the free LAnKe with 3n − 2 generators is also presented. We also obtain a new presentation of Specht modules of shape λ, where λ has strictly decreasing column lengths, as a consequence of our eigenspace result.
Adult Onset Henoch-Schonlein Purpura Following Varicella-Zoster Virus Infection (Chickenpox)

Henoch-Schonlein purpura (HSP) is a form of cutaneous small vessel vasculitis that can involve visceral organs and is associated with deposition of immunoglobulin-A (IgA) containing immune complexes. HSP commonly manifests after an antecedent infection with palpable purpura, lower limb arthritis, pain abdomen and microscopic hematuria. The clinical profile of adult HSP varies from that of childhood in severity, outcome and history of antecedent infection. We herein report a case of adult onset HSP following varicella infection which to our knowledge has not been reported in the literature.
Incidental findings in a consecutive series of digital panoramic radiographs

Purpose The aim of this study was to determine the prevalence of incidental findings (IFs) on digital dental panoramic radiographs (DPRs) of asymptomatic patients attending a general dental practice. Materials and Methods This was a retrospective study of 6,252 consecutive digital (photostimulatable phosphor) DPRs of patients who visited a Canadian general dental practice for a complete new patient examination. The IFs were grouped into dental-related anomalies, radiopacities and radiopacities in the jaws, changes in the shape of the condyles, and other findings in the jaws, such as tonsilloliths and mucosal antral pseudocysts. Their prevalence was determined. Results Thirty-two percent of the DPRs showed at least 1 IF. The highest prevalence was found for dental-related anomalies (29% of all DPRs), of which impacted teeth were the most prevalent finding (24% of all DPRs), followed by idiopathic osteosclerosis (6% of all DPRs). A lower prevalence was noted for tonsilloliths (3%), and the prevalence of root tips, mucosal antral pseudocysts, and anomalies in condylar shape was approximately 1% each. Conclusion The observed prevalence of 32.1% for IFs of any type underscores the need for a dental practitioner to review the entire DPR when a patient presents for an initial dental examination (or check-up) or for dental hygiene. Only a single IF (a central giant cell granuloma) provoked alarm, as it was initially considered malignant. Similarly, impacted teeth and suspected cysts need careful evaluation upon discovery to determine how they may be optimally managed.
Form of Teacher Communication in Handling Students with Special Needs in Madrasah

Communication is a basic human activity. By communicating, human can interact to each other. No one has never involved in communication. The importance of communication for as human being cannot be denied, In the world of education, the on going communication will, of course, be related to values and encouraged changes. Because communication is carried out based on aiming the values as well as realizing. Students with Special Needs are those who need special treatment related to their case. Since students with special needs are different from the typical ones, education and teaching have to be strongly related to their needs. That is the reason why special education is taking part of it. In the communication process, message is one of the important component. The content of the message communicating is one of the main components of human communication as well as the messages communicating in educational communication, especially for Madrasas (primary school) that have students with special needs. Besides the educational communication, the delivery is also play an important role. In the process of communication, in addition to the delivery of learning material, it is important to communicate by including: (1) teacher's positive expectations as a major impact on student achievement. The teacher's positive expectations of students’ behaviors and attitudes that support the achievement of learning objectives. (2) The goals and results of learning are the heart of the learning process. The purpose of giving direction on what will be learned. It is also the basic foundation of the learning plan as expected. (3) Feedback and Evaluation, which are the most important components in education that aim to improve or to find out the success of communication that the writers do in the learning process. From the 4 madrassas in Bogor, researchers found two forms of teacher communication in dealing students with special needs, namely; interpersonal communication, when the teacher give explanations to the typical students, he allocate part of his time to give attention, guidance and teaching to children with this special students; and group communication where the teacher as a communicator delivers his message in the form of knowledge or subjects to students in group, but it is also possible if they use interpersonal communication at certain times, especially if they are dealing with other members who need special treatment and attention.
Some parasitic and bacterial causes of liver affections in ruminants

In the present study, a total number of 1576 livers of ruminants, including cattle (924), sheep (487) and camels (165) were examined for detection of different pathogenic agents. Among those, a number of 58 cases (3.68 %) were infected with both parasites and bacteria. Out of this number, 3 cases only (0.19 %) were infected with bacterial species (Lactobacillus lactis lactis), 31 cases (1.97 %) were infected with parasitic stages only and a number of 24 cases (1.52 %) were co-infected with both bacteria and parasites. Among the bacterial isolates, 11 genera of bacterial species were found in 27 cases. The obtained results revealed that, all infected cases were cattle. The most prevalent isolate was Enterococcus species which present in 7 cases (25.92 %) among the totally bacterial infected cases, followed by 5 cases showed Staphylococci (18.52 %), then both genus Escherichia and genus Lactobacillus, each was found in 4 cases (14.81 %) and finally 7 genera including;Enterobacter,Micrococcus,Citrobacter,Aerococcus,Pseudomonas,Chrysomonas and Streptococcus; each was found in a single case with a percentage of 3.70 %. Concerning the parasitic affections, it has been found that Fasciola species was the most prevalent type of helminthes present in the infected livers. Among all infected livers, 40 cases (2.54 %) were infected with adult Fasciola gigantica (including 33 cattle and 7 sheep), followed by 8 cases of camels (0.51 %) infected with Hydatid cysts, then 4 cases of sheep (0.25 %) infected with Cysticercus tenuicollis and finally 3 cases of sheep (0.19 %) infected with both Fasciola gigantica and Cysticercus tenuicollis. The results revealed that, a considerable high number of co-infected animals {24 cases (41.38 %) among the totally infected animals} was existed and this reveals that the parasite facilitates the way to the secondary bacterial infection with the end results of hepatic tissue degeneration and necrosis. So, in abattoirs, great attention must be taken for appropriate evaluation of these pathogenic sources.
Combined Effects of Selenium and α-Tocopherol on Quality and Fertilising Ability of Spermatozoa in Extended Cock Semen Processed and Inseminated On-Farm

Spermatozoon apoptosis in extended semen is a challenge to artificial insemination in poultry production. Extender supplementation with exogenous antioxidants could mitigate lipid peroxidation and improve semen quality. Therefore, effects of selenium and α-tocopherol on quality and fertilising ability of spermatozoa in extended cock semen were assessed. Semen samples were collected from fifteen Lohmann breeder cocks aged 40 weeks, pooled and divided into five groups. Each group was extended with Ringers Solution (RS) without antioxidant (T1), RS+25μgmL -1 α-tocopherol (T2), RS+25μgmL -1 selenium (T3), RS+12. 5μgmL -1 α-tocopherol+12. 5μgmL -1 selenium (T4), RS+25μgmL -1 selenium+25μgmL -1 α-tocopherol (T5) were assessed in vitro and in vivo. All treatments were evaluated for Spermatozoa Progressive Motility (SPM), Spermatozoa Liveability (SL), Total Antioxidant Capacity (TAC, mmol/L) and Lipid Peroxidation (LP, MMDA/l0 Spermatozoa) were determined using standard procedures. Seventy-five Lohmann breeder hens aged 40 weeks were divided into five groups and inseminated with each of the treatments under room temperature for the in vivo evaluation. Egg fertility and hatchability were recorded weekly for four weeks. Data were analysed using descriptive statistics, correlation and ANOVA at α0.05. Result showed that the effect of αtocopherol and selenium combinations were not (p>0.05) different among treatments for SPM, SL and LP up to 6h. Egg fertility was (p<0.05) higher at T1 (86.5±7.3%), T2 (86.0±7.6%) and T3 (82.0±5.0%) than T4 (57.0±7.1%) and T5 (72.3±8.7%), while hatchability of set eggs ranged between 40.0±8.8% (T2) and 71.3±10.2% (T3). Fertility positively correlated with hatchability (r=0.95). Selenium inclusion at 25μgmL -1 under room temperature improved hatchability in Lohmann breeder hens. Additional
Assessment of nutritional status of adolescent girls residing in rural area of Belagavi

Background: Adolescence is a period of transition between childhood and adulthood. Health and nutrition of the girls will affect the health and survival of future generation. However, there is very little information about the nutritional status of adolescents, particularly from rural areas in India. In view of the above facts, an attempt was made to assess the nutritional status of rural adolescent girls.
Reproducibility and The Effects of Exercise on The Endurance Index

iii List of Tables . vi List of Figures . vii Chapter 1: Introduction . 1 Chapter 2: Literature Review . 4 Chapter 3: Methods . 14 Chapter 4: Results . 20 Chapter 5: Discussion . 34 References . 40
Comparison of Measured Gfr by Tc-99m-dtpawith Estimated Gfr in Potential Kidney Donors at Kenyatta National Hospital

ix Glomerular filtration rate measurement.1 Estimation of glomerular filtration rate.4 Study justification.8 Research question.9 Study objectives.10 Methodology.11 Results.14 Discussion.19 Conclusions.25 Limitations and recommendations.26 List of references.27 Appendices.31 Appendix 1: Data collection form. 31 Appendix 2: Consent information document. 32
Physiological Response to the Stress Effect of Anesthesia and Surgery in Sheep and Goat

The present study was established to evaluate and compare stress response to anesthesia as well as surgery in sheep and goat. For this purpose, 5 rams and 5 bucks underwent anesthesia alone followed a week later by anesthesia with rumenotomy. Serum cortisol levels as well as differential leucocytic count were assayed just prior to anesthesia (0 time) and then after 1, 2, 4, 6 and 24 hours post anesthesia. In the second experiment, blood samples were collected just prior to anesthesia (0 time) then after half an hour (0 time post rumenotomy) then after 1, 2, 4, 6 and 24 hours post completion of rumenotomy. Serum cortisol levels in both species increased significantly and reach its peak one hour following anesthesia (3.31 ± 0.17 and 4.09 ± 0.12, respectively) which were higher than subsequent cortisol levels. In addition, Peak cortisol level in sheep obtained at 0 time post rumenotomy (4.39 ± 0.13) and 1 hour following rumenotomy in goat (3.45 ± 0.16). The significant increase in cortisol level persists for 6 hours and returns to normal level 24 hours following surgery.
Home-Advantage Decision-Making: Experiences Of Soccer Referees At The 23rd GUSA Games

Soccer teams seem to win most of their matches when they compete at home compared with when they compete away from home. This is partly attributable to the home-advantage decisions referees‟ award to the home teams. This study used qualitative methods to explore the views of referees who officiated soccer matches at the 23rd GUSA games held at the University of Cape Coast, Ghana, on the phenomenon. Also, theoretical concepts were exploited from knowledge-based repositories on home-advantage decisions. Seven experienced referees were selected to supply information through an adapted semi-structured interview protocol. Content analysis procedures identified nine inter-related factors that define three higher-order themes. The factors; experience, opinion and control form a higher-order theme labelled personal factors. Crowd aggression, team reception, play conditions, and player reaction were identified as situational factors, and geographical location and travel conditions represented environmental themes. All the nine factors inter-relate to influence the decision-making efficiency of referees when officiating soccer matches. It was recommended that referees pay particular attention to the home-advantage themes and models expatiated in this study to become aware of varied factors that underlie the award of home-advantage decisions. This will enable referees device appropriate strategies to cope with the factors. Also, the activities of referees should be monitored via the use of electronic monitoring systems such as video technology at all league centres to force referees rescind arbitrary decisions they make on the field of play. This is likely to lead to a reduction in biased officiating.