Miracle-dz/UniFAR-FTUs huggingface dataset:
Abstract. Non-antibody-binding proteins (nABPs) have attracted attention in the field of alternative antibody approaches due to their ability to penetrate cell membranes. CD105 has been demonstrated to be a useful marker for identifying angiogenic endothelial, mesenchymal stem and osteosarcoma cells

Non-antibody-binding proteins (nABPs) have attracted attention in the field of alternative antibody approaches due to their ability to penetrate cell membranes. CD105 has been demonstrated to be a useful marker for identifying angiogenic endothelial, mesenchymal stem and osteosarcoma cells. In the present study, a novel non‐antibody‐binding protein (namely nABP296) with a high affinity for recombinant human CD105 was identified by M13 phage biopanning. Fluorescence microscopy, flow cytometry and in vivo animal imaging were used to confirm the visualization effect of the novel peptide to the CD105‐positive MNNG/HOS cell line in vivo and in vitro. Immunofluorescence of tissue sections was also used to identify the target efficiency of the peptide in tumour sections derived from an MNNG/HOS xenograft tumour model and osteosarcoma patients. This peptide specifically was found to bind to the CD105‐positive osteosarcoma MNNG/HOS cell line and the osteosarcoma cells in the histological sections derived from an MNNG/HOS xenograft model and osteosarcoma patients in vitro. This peptide also successfully labelled an animal osteosarcoma xenograft model in vivo. Taken together, a novel peptide that can be used as a potent agent for CD105 molecular targeting was identified, and this peptide can be applied for osteosarcoma visualization in vitro and in vivo.
Selection effects in Dutch exporting firms

We present unique data on the microstructure of Dutch exports and the relation between export participation and productivity at the firm level. We test whether recent theories of international trade with heterogeneous firms can explain the patterns found in Dutch data. We find significant evidence that firms self-select into export participation, even after controlling for input structure, size and market characteristics. In general, only the most productive Dutch firms participate in exports and foreign direct investment. We compare our results for Dutch firms with similar results from other countries and we discuss the implications for trade policies.
ADVANCES IN ACUTE MYELOID LEUKEMIA Hematopoietic stem cell transplantation for patients with AML in first complete remission

Although the majority of patients with acute myeloid leukemia (AML) enter remission upon induction chemotherapy, the risk of relapse is considerable. That risk varies greatly according to age and genetic subtype as major denominators. Taking an increasingly detailed risk evaluation into account, the intensity and type of postremission therapy is generally tailored according to risk profile, whereby chemotherapeutic consolidation is favored in good-risk AML and allogeneic hematopoietic stem cell transplantation (alloHSCT) is favored in poorrisk AML. These approaches are currently weighed and debated in intermediate-risk AML, and interest in autologous HSCT (autoHSCT) has recently been revived. The last decade has witnessed an enormous increase in knowledge of the pathogenesis of AML. Genetic characterization has yielded important prognostic information, which has necessitated taking the most important mutational aberrations into account for therapeutic decision making. Furthermore, translational research has now establishedAMLas amulticlonal disease that develops stepwise according a Darwinian model of leukemogenesis. The latter insight has important consequences for therapy, because it became unlikely that targeted monotherapies aimed at a single AML oncogene could match the efficacy of the tyrosine kinase inhibitors in monoclonal malignancies (eg, chronic myeloid leukemia). Indeed, current therapeutic developments aim to incorporate targeted therapy into established intensive chemotherapeutic schedules. In addition, the advent of new treatment modalities such as chimeric antigen receptor T cells and various monoclonal antibodies has renewed interest in immunotherapeutic approaches for treatment ofmulticlonal leukemias such asAMLandacute lymphoblastic leukemia. A particularly potent immunotherapeutic approach is the allogeneic graft-versus-leukemia (GVL) effect, which has been shown to exert its influence across all genomic subsets with similar relative potency.However, its inherent toxicity is increasingly being debated, which makes using transplantation protocols associated with an acceptable limited toxicity profile a greater necessity. Conversely, the urge to preserve and exploit the GVL effect is an important issue, especially in the poor-risk genetic subtypes of AML. Here, we address 3 important issues in the field of postremission therapy by alloHSCT or autoHSCT in first complete response (CR1) in patients with AML:What is the current place of reduced-intensity conditioning (RIC) and nonmyeloablative (NMA) alloHSCT in both older and younger patients with AML in CR1? Which type of alternative donor is currently preferred and what is the current status of haploidentical donor transplantation in AML? Is autoHSCT a valuable alternative for alloHSCT in intermediate-risk AML?
Knowledge and Attitudes towards Healthcare Information Technology of the Rural Health Workers in SAMARICA, Occidental Mindoro, Philippines

The descriptive research aims to determine the socio-demographic characteristics of the healthcare providers, the health workers’ knowledge of and attitudes towards computer applications and the relationship between socio-demographic characteristics of the healthcare providers and their knowledge of and attitudes towards computer applications. The study was conducted in the Rural Health Units of San Jose, Magsaysay, Rizal & Calintaan, Occidental Mindoro from March 2017 to June 2018. The 51 health workers were purposively selected as respondents of the study. Survey and interview were used to gather the data needed. Descriptive statistics and Pearson Moment Correlation were used to analyse the gathered data. Results shows the healthcare providers are female, young, college graduate, and have long work experience in the maternal and newborn care section and had assisted the rural health doctor during consultations. The healthcare providers have “high” level of knowledge on computer and its applications and had expressed “positive” attitudes towards the use of computers in their work. Further, only age has a significant relationship with the healthcare providers’ knowledge of and attitude towards computer applications.
Family-centered care in a pediatric intensive care unit: professionals’ perceptions

Objetivo: identificar a percepcao dos profissionais com relacao ao cuidado centrado na familia. Metodos: estudo descritivo transversal com 60 profissionais de uma unidade de terapia intensiva pediatrica e aplicou-se o instrumento Percepcao do Cuidado Centrado na Familia-Equipe versao brasileira. Os dados foram analisados a partir da estatistica descritiva e analitica, utilizou-se o teste t-Student e o teste de Mann-Whitney para comparacao entre as variaveis. Resultados: a media do escore de percepcao do cuidado centrado na familia foi 2,93 (±0,27), mediana de 2,90, escore maximo de 3,50 e minimo de 2,30. A maioria dos profissionais (60,0%) considerou que o cuidado centrado na familia as vezes e praticado. Os escores medios nao apresentaram diferencas estatisticamente significantes entre as variaveis de caracterizacao da equipe. Conclusao: percepcao de cuidado distante das recomendacoes de um cuidado ampliado que agrega a crianca e sua familia.
Keeping the Fingers Running: The Impact of IT Innovativeness on Job Relevant Uses of the Internet 1

This paper investigates whether organizational members job relevant use of Internet could be explained by personal innovativeness in information technology and other individual traits like age and experience with IT. To address this issue, the paper starts with an examination of job relevant versus private use of Internet. Thereafter the focus is on how personal innovativeness in information technology influences organizational members use of Internet. The results indicates that users perceive structural differences across various types of Internet usage areas, although it was not obtained any clear support for a distinction between job relevant and private use in this study. Additionally, the findings shows that the ratio of private use is considerable lower than job relevant use. The test of how individual traits influence use of Internet shows that the contribution from personal innovativeness has the greatest impact on employees(cid:146) use of Internet.
A Model of Geography, Income and Growth

In a series of papers, Jonathan Eaton and Samuel Kortum (Eaton and Kortum, 2002, 2001 and 1999) have developed a new framework for analyses of international trade, productivity and growth. The modelling framework takes as point of departure a probabilistic distribution of productivity among countries, derived as a result of a search-theoretical model of technological change. By use of a specific probability distribution (the extreme value distribution of type II), implications for relative productivity, international trade and economic growth is derived. It is shown that some modifications of the Eaton-Kortum framework give rise to three regularities, known from empirical research: The first is the gravity equation for bilateral trade, the second is a ‘market potential’ expression for levels of GDP per capita and the third is a spatial lag model of economic growth. * This paper has been prepared as a part of the project “Policy regimes, Efficiency and Distribution” sponsored by the NFR-program The Multilateral System in the Field of Development. I thank Leo Andreas Grünfeld, Arne Melchior and Hege Medin for valuable comments. Correspondence: The Norwegian Institute of International Affairs, P.O. Box 8159 Dep. , N-0033 Oslo. E-mail: PerB.Maurseth@nupi.no.
Learning Deep Fair Graph Neural Networks

Developing learning methods which do not discriminate sub-groups in the population is the central goal of algorithmic fairness. One way to reach this goal is to learn a data representation that is expressive enough to describe the data and fair enough to remove the possibility to discriminate subgroups when a model is learned leveraging on the learned representation. This problem is even more challenging when our data are graphs, which nowadays are ubiquitous and allow to model entities and relationships between them. In this work we measure fairness according to demographic parity, requiring the probability of the possible model decisions to be independent of the sensitive information. We investigate how to impose this constraint in the diﬀerent layers of a deep graph neural network through the use of two diﬀerent regularizers. The ﬁrst one is based on a simple convex relaxation, and the second one inspired by a Wasser-stein distance formulation of demographic parity. We present experiments on a real world dataset, showing the eﬀectiveness of our proposal.
User-Centred Software Product Certification: Theory and Practices

Previous researches on software certification provide models and frameworks that work on traditional approaches such as block box testing, developer’s assessment and internal audit of the technical aspects of software. For the past seven years, our research focused on development of software certification product towards user-centred approach. We believe that the technical aspects of quality will be taken care by the technology. Two preliminary works were undertaken to study the issue of certification and as a result, two fundamental models of software certification were constructed successfully. The models have been developed using requirement-design-implementation strategy to ensure that it meets the needs of a number of different interest groups in the industry. These models focused on certifying software by development process and product quality approach respectively. The models have been tested in case studies, which were launched collaboratively with industries in Malaysia. A significant advantage of our model is that it allows users to choose and design their implementation model of certification which fit with their organization’s requirements and expectations. This paper presents the opportunity provided by this research that the certification model developed does not only offering a mechanism for certification process, but also providing an alternative mechanism for monitoring of quality and continuous improvement of software quality throughout its life span.
Is Information Systems Misuse Always Bad? A New Perspective on IS Misuse in Hospitals Under the Context of Disasters

Although the extant literature has investigated how individuals engage in inappropriate behaviors based on the rational choice theory (RCT) (e.g., computer misconduct), the neutralization theory (e.g., IS security policies violation), and workarounds under normal situations, it has given little consideration to how individuals are involved in misuse of information systems with a good intention under the context of disasters. To fill this research gap, we propose a selfless misuse model, which offers a theoretical explanation for the concept of individuals’ selfless misuse intention under uncertainty caused by disasters. In this study, we show why employees make decisions to misuse the information system to ensure delivery of health services and business continuity. In addition, we explore the way of reducing this misuse behavior by introducing the role of system resilience in assisting employees to make better decisions and act positively.
Assessment of Prescription Pattern of Hypertensive Patient's Prescription: A Prescription Survey Study from Various Hospitals of Bangladesh

In the medicine practice, there is a growing concern regarding the irrational prescription pattern and use of antihypertensive drugs. To examine the patterns of antihypertensive prescription in the management of systemic hypertension associated with various other chronic diseases such as diabetes, hyperlipidemia etc, data was collected through prescription survey from various hospitals in Bangladesh. 418 prescriptions were collected from Out Patient Department of four hospitals, which are the National Heart Foundation, National Institute of Cardiovascular Diseases, Bangladesh Medical College, Assessment of Prescription Pattern of Hypertensive Patient’s Prescription: A Prescription Survey Study from Various Hospitals of Bangladesh 501 and Bangladesh Institute for Research & Rehabilitation in Diabetes Endocrine and Metabolic Disorders, for the period of July to December 2008. This study confirms that the quality of prescriptions, both in terms of layout and the content of the drugs prescribed, is inadequate in case of hypertensive patient’s treatment. Also the study reflects the immediate urgency to develop an independent mechanism for practitioners to ensure that the patient gets proper evidence-based treatment.
Education, Status and Income – An Established Triangle Disrupted by New Qualifications?

This article examines the relations between employees’ educational attainment and their income as well as their social status, considering the individuals’ social background. The data derive from the German BIBB/BAuA Employment Survey 2012. Social status is analyzed for the individuals’ first job and their current job using the International SocioEconomic Index of Occupational Status (ISEI). The results show that academic and further vocational qualifications have a positive effect on employees’ income compared to initial vocational qualifications. Especially academic qualifications are positively related to employees’ social status, while over time also (initial and further) vocational qualifications have a positive effect. The individuals’ social background is also positively related to their educational attainment – mostly for the group of academically qualified employees.
V. Time-Resolved Spectroscopy of Correlated Electron Materials

“Electron correlation” is a dominant theme in condensed matter science, manifesting itself in, e.g., “metal-insulator transitions” (MIT), “high-temperature superconductivity” (HTS) and “colossal magneto-resistance” (CMR). On the microscopic scale, one speaks of the charge (C), spin (S) and orbital (O) degrees of freedom, each of which may show shortor long-range order, and each of which may exchange energy with the others and with the crystal lattice (L) (see Fig. V.1). Important correlation effects can occur in systems with partially-filled electron shells, such as those of 3d-transition metal ions, with anisotropic, quasi-localized character. Vast amounts of experimental and theoretical work have been published on electron correlation, triggered largely by the discovery of HTS in
TRADE AND ETHNIC DIVERSITY IN SOUTH-EASTERN EUROPE: A GRAVITY APPROACH

The goal of this work is to analyze the influence of ethnic concentration on trade exchanges between the countries of Southeastern Europe, study that is motivated by the situation of nation-state relation in this region. The ethnic diversity, in comparison to the linguistic or religious one, has the advantage to reflect the socio-political situation of the region: the same language spoken by different ethnicities, and the same religion for diverse nationalities. At the same time, the same minorities living in different countries, and the strong historic and cultural ties between the countries, show the ethnic filiations in Southeastern Europe. Considering the cultural rapprochement, it is obvious to demand how this situation influences the economic relations of these countries in the circumstances of recent conflicts and of the (potential) integration in the EU. For this analysis we are using the gravity model. We follow the method of Santos & Tenreyro (2005), of pseudo-Poisson Maximum Likelihood. The estimation is realized with cross-section data for five years of transition, fact that will allow us to observe the trade evolution in the region. To represent the ethnic diversity, we use the indicator of ethnic fractionalization. It allows to capture the impact of society fragmentation on the trade volume (as we know, there are no studies on this aspect). In order to take into consideration the linguistic (and, thus, cultural) filiations between countries, we include two dummy variables for minority languages. The results show that the ethnic fractionalization has a positive influence on trade relations, as the minority languages influence but the last is less significant. The presence of recent conflicts between the countries has a positive impact on the trade volumes; it diminishes the weight of inter-ethnic networks within the country, but increases the inter-state relations that are linguistically close. The communist past (less significant last years) and the signed agreements do not influence the cultural aspect of the trade. * PhD. student, Academy of Economic Studies of Moldova, email: gonta_elena@yahoo.fr
Effects of a Nano-structured Surface Layer on Titanium Implants for Osteoblast Proliferation Activity

The goal of this study is to compare surface morphologies on dental implants created by a range of five different surface-modification technologies and, in addition, cell assays to assess the subsequent cell proliferation on each treated surface. In our research, we surface-treated 5 mm-diameter – 2 mm-thick discs, machined from Grade 1 titanium. We treated the surfaces of the discs with chemical etching, electro-polishing, Al2O3 sandblasting, and surface melting with 1 Joule or 3 Joule impulse-energy laser beam. We carried out quantitative as well as qualitative analyses with stereo and scanning electron microscopes (SEM), confocal and atomic force microscopes (AFM) and goniometer. We examined each surface with cell-testing, as a measure of osseointegration. In tests with fibroblasts, the highest cell proliferation occurred on the Al2O3-roughened surfaces. In the case of osteoblasts, we measured the greatest cell activity on the laser-melted samples with different energy levels.
SUBSURFACE DRIP IRRIGATION: AN INNOVATIVE TECHNIQUE TO IRRIGATE DATE PALM IN OASIS

Water saving has becoming imperative for oases sustainability. One of the options, being actively explored, is the use of surface drip irrigation for water saving, but its use in sub-desert regions does not protect water from evaporation. An alternative to this system would be the use of subsurface drip irrigation (SDI). Actually, the performance of SDI, according to several research studies, differs according to the climatic, soil and cultural conditions, in addition to the knowledge gaps concerning the water distribution from a buried source on real conditions. This document deals with its application to date palm in the oasis of Tafilalet (south-eastern Morocco), where appropriate design and management of this system should be proposed to farmers. The objectives of this research are: to evaluate in situ the performance of SDI on real conditions (farm plot); and to model the functioning of SDI and provide design criteria to irrigate young date palm using Hydrus 2D. The results of this study showed that SDI is an efficient technique that can contribute to sustainable irrigation in oases. In fact, this system allows a better water efficiency, a substantial water saving, an improvement of the marginal land development, an elimination of surface evaporation and a reduction of the risks of water stress. However, it is important to know the climatic, pedological, agronomic and even socioeconomic conditions in which this system will be used to ensure its proper functioning and improve the water use efficiency.
Differences Between Recent Heat Flow Maps of Poland and Deep Thermo-Seismic and Tectonic Age Constraints

Poland is situated in a place of contacts between three continental scale geologic structural units: the Precambrian East European Craton (EEC) to the northeast, the Variscan West European Platform (WEP) terranes to the southwest, and the younger Carpathian Alpine arc in the south. The Trans-European suture zone (TESZ) between the EEC and WEP is a deep-seated discontinuity zone reaching down to a depth of about 200 km. The conjunction of all these continental scale geologic units is reflected in the complex tectonic structure of this area. Apart from the complex seismic structure, this area is also associated with pronounced gravity, magnetic and heat flow anomalies. Significant differences exist between heat flow maps of Poland published in recent works, with values reaching 20 to 30 mWm-2. Examples are differences in heat flow based on models that use well log interpreted mineral and porosity content and assigned world averages of rock and fluid thermal conductivities versus ones based on averaging thermal conductivity values measured using borehole cores only. These differences in heat flow between the methods are discussed in the context of their relationship with tectonic age. Also considered are depth differences between lithosphere – asthenosphere boundary (LAB) derived from thermal model vs those that obey seismological constraints. Higher heat flow estimates reaching up to or more than 100 mWm-2, based on conductivity values derived from well-logs, are found to be quite improbable. This likely reason for overestimate of heat flow is discussed.