Miracle-dz/UniFAR-FTUs huggingface dataset:
Metastatic and synchronous ovarian involvement in low-risk endometrial cancer; clinicopathological analysis with detection of DNA mismatch repair deficiency.

OBJECTIVES This study aimed to investigate ovarian involvement in low-risk endometrial cancer, the associated risk factors, and impact on overall survival. We attempted to explore the differences in mismatch repair (MMR) deficiency between metastatic and synchronous ovarian tumoral involvement. MATERIAL AND METHODS This was a retrospective study of patients with low-risk endometrial cancer who were treated at a tertiary center between January 2006 and December 2019. The primary outcome measures were the incidence and risk factors associated with metastatic and synchronous tumoral involvement of the ovary. Overall, survival data were also analyzed. Metastatic and synchronous tumors were compared with each other in terms of MMR deficiency with IHC staining. RESULTS From a total of 360 low-risk endometrial cancer patients, 10 (2.8%) had ovarian metastasis and 12 (3.3%) had synchronous ovarian involvement. The median age of patients with metastasis was significantly lower than that of patients without ovarian involvement (49 vs 57 years, p = 0.004). Most patients in the metastatic group were in the < 50 age group (p < 0.001) and premenopausal period (p = 0.001). As a result of IHC staining performed on patients with ovarian involvement, MMR deficiency was found in six (60%) patients in the metastatic group and six (50%) patients in the synchronous group. No significant difference was found in overall survival between groups. CONCLUSIONS Younger age and premenopausal status were risk factors associated with ovarian metastasis. Overall survival did not show differences between all groups, and MMR deficiency was similar between metastatic and synchronous groups.
Myths and Evidence Regarding Melatonin Supplementation for Occasional Sleeplessness in the Pediatric Population.

Occasional sleeplessness in children is common, with as many as 25% of all healthy children experiencing a problem sleeping at some point over the course of their childhood. Occasional sleeplessness is poorly understood, has a significant impact on quality of life in children and their families, and is often challenging to manage. There is substantial evidence supporting the safe and effective use of the widely available dietary supplement melatonin for children with chronic conditions. This article summarizes the views expressed in a recent Consensus Panel meeting convened to evaluate the use of melatonin in children, as well as the published scientific literature related to the effectiveness and safety of melatonin, with a focus on occasional sleeplessness in healthy children. We provide an evidence-based framework for the implementation of a standard process to effectively manage occasional sleeplessness in children and adolescents. Unsubstantiated concerns in the past may have limited melatonin's use in children with conditions for which the supplement may support a better sleep pattern and, by doing so, may help to improve quality of life. Melatonin dietary supplements using high quality standards may be provided to children together with cognitive-behavioral therapy after proper sleep evaluation and after improved sleep hygiene, family education, and sleep diary activities have failed to resolve sleep difficulties. [Pediatr Ann. 2021;50(9):e391-e395. ].
Functional outcomes and user preferences of individuals with transfemoral amputations using two types of knee joints in under-resourced settings

Background: Information relating to prosthetic performance can inform clinical practice and improve patient outcomes in under-resourced countries. Objectives: The main goal of this study was to compare functional outcomes and user preferences of individuals with transfemoral amputations using common types of knee joints in an under-resourced country. Study design: Prospective, longitudinal, before and after trial. Methods: Twenty individuals with unilateral transfemoral amputations from a center in Cambodia transitioned from a commonly used single-axis manually locking knee International Committee of the Red Cross (ICRC) to a more advanced multiaxis knee joint with stance control All-Terrain Knee (ATK). Data were collected for the ICRC knee joint and the ATK immediately after fitting, after acclimation, and as part of a long-term follow-up. A timed walk test assessed walking distance and efficiency. Mobility and user-preferences were evaluated through questionnaires. Results: Distance during the timed walk test was significantly higher for the ATK compared with ICRC (P < 0.001), with functional gains retained at follow-up. No differences were found for gait efficiency and the mobility questionnaires. All participants, except one, preferred the ATK prosthesis. Benefits included greater knee stability and fewer perceived knee collapses; however, some disliked the appearance of the ATK. Conclusions: The findings suggest positive outcomes with prosthetic services in under-resourced regions and the ICRC system, as well as the potential for improved functional outcomes with more advanced multiaxis knee components.
Nutrient digestibility and production responses of lactating dairy cows when saturated free fatty acid supplements are included in diets: A meta-analysis.

Our objective was to perform a series of meta-analyses to evaluate the effects of diets supplemented with saturated free fatty acid (FA) supplements (SFAA) compared with nonfat supplemented control diets (CON) on nutrient digestibility and production responses of lactating dairy cows and to determine whether experimental design affects responses to SFFA. We divided SFFA into C16:0-enriched supplements (PALM, FA supplements with ≥80% C16:0) and C16:0+C18:0-enriched supplements (MIX, FA supplements with ≥80% C16:0+C18:0). The database was formed from 32 peer-reviewed publications with SFFA supplemented at ≤3% diet dry matter (DM). We completed 3 different meta-analyses to meet our objectives. We analyzed the interaction between experimental design (continuous vs. change-over) and treatments (CON vs. SFFA; Meta.1). Regardless of experimental design, we evaluated the effect of treatment (CON vs. PALM vs. MIX; Meta.2) and the effect of 1-percentage-unit increase of MIX and PALM in diet DM (Meta.3). In Meta.1, there was no interaction between treatments and experimental design for any variable. In Meta.2, compared with CON, MIX had no effect on NDF digestibility, milk protein yield and energy corrected milk (ECM), increased the yields of milk (1.20 kg/d) and milk fat (0.04 kg/d), and decreased FA digestibility (5.20 percentage units). Compared with CON, PALM increased NDF digestibility (4.50 percentage units), the yields of milk (1.60 kg/d), milk fat (0.10 kg/d), milk protein (0.04 kg/d), and ECM (2.00 kg/d), and had no effect on FA digestibility. Compared with MIX, PALM tended to increase FA digestibility (3.20 percentage units), increased NDF digestibility (3.50 percentage units), milk fat yield (0.06 kg/d), and ECM (1.20 kg/d). In Meta.3, for each 1-percentage-unit increase of supplemental FA in diet DM, MIX had no effect on NDF digestibility, decreased FA digestibility, increased the yields of milk and milk fat, had no effect on milk protein yield, ECM and milk fat content, and decreased milk protein content. For each 1-percentage-unit increase of supplemental FA in diet DM, PALM increased NDF digestibility, had no effect on FA digestibility, increased the yields of milk, milk fat, ECM and milk fat content, tended to increase milk protein yield, and had no effect on milk protein content. Our results indicate no reason for the restrictive use of change-over designs in saturated FA supplementation studies and meta-analyses. Lactating dairy cows responded better to a FA supplement enriched in C16:0 compared with one containing C16:0 and C18:0.
The role of weather conditions on time spent outdoors and in moderate-to-vigorous physical activity among Norwegian preschoolers

ABSTRACT The aim of this study was to determine associations between weather and playground surface conditions and time spent outdoors and in moderate-to-vigorous PA (MVPA) in preschool children aged 3–6 years. We included 1201 children (mean age 4.8 years, 51% boys) from 68 preschools in Norway who provided 12,030 days of observation during 2015–2016. Preschool MVPA was measured by accelerometry (ActiGraph GT3X+) for 10 consecutive weekdays. During this period, outdoor time and playground surface conditions were logged by staff and weather conditions were obtained from the Norwegian Meteorological Institute. Associations were determined using linear mixed models. Associations for MVPA depended on whether the analyses were adjusted for outdoor time or not. In unadjusted analyses, rainfall, wind, and wet, icy, and mixed playground conditions were negatively associated with MVPA, while temperature, snowfall, and dry playground conditions were positively associated with MVPA. In adjusted analyses, temperature and wet and mixed playground conditions were negatively associated with MVPA, while snowfall and dry and snowy playground conditions were positively associated with MVPA. Outdoor time and MVPA should be addressed simultaneously to inform interpretation of associations with weather characteristics and intervention development in early childhood education settings.
Effective incentives for increasing COVID-19 vaccine uptake

Abstract In this study, we examined the relative effectiveness of prestige-based incentives (vaccination of an expert scientist/president/politician/celebrity/religious leader), conformist incentives (vaccination of friends and family) and risk-based incentives (witnessing death or illness of a person from the disease) for increasing participants' chances of getting vaccinated with respect to their coronavirus disease 2019 (COVID-19) vaccine intention. We conducted a cross-cultural survey using demographically representative samples from the UK (n = 1533), USA (n = 1550) and Turkey (n = 1567). The most effective incentives in all three countries were vaccination of an expert scientist, followed by vaccination of friends and family members and knowing someone dying from the disease. Vaccination of an expert scientist was significantly more effective at increasing vaccine intention than any other incentive. Vaccine incentives, regardless of the incentive type, were much less effective for those who originally refused the COVID-19 vaccine than for those who were hesitant to receive the vaccine. Although the percentage of vaccine-hesitant participants was highest in Turkey, the mean effectiveness scores of incentives were also the highest in Turkey, suggesting that an informed vaccine promotion strategy can be successful in this country. Our findings have policy applicability and suggest that positive vaccination messages delivered by expert scientists, vaccination of friends and family and risk-based incentives can be effective at increasing vaccine uptake.
Balancing Injury Risk and Power Development by Weighted Jump Squat Through Controlling Eccentric Loading

Abstract Songsupap, T, Newton, RU, and Lawsirirat, C. Balancing injury risk and power development by weighted jump squat through controlling eccentric loading. J Strength Cond Res 35(11): 2999–3005, 2021—Weighted jump squat (WJS) training is highly effective for increasing neuromuscular power but entails higher injury risk than traditional resistance training because of the impact of landing. Braking mechanisms can be used to control the landing impact; however, the optimal eccentric loading condition that balances injury risks and power output is still unclear. The purpose of this study was to assess different eccentric braking conditions. Twenty-two male varsity basketball players aged 20.8 ± 1.1 years and a 1 repetition maximum (1RM) of back squat-to-body mass ratio of 2.0 ± 0.2 participated in the study. The subjects performed 2 sets of WJS of 6 repetitions with additional 30% of 1RM load under 4 randomly assigned conditions: (a) traditional load, no braking (B0), (b) 25% braking load reduction during landing (B25), (c) 50% braking load reduction during landing (B50), and (d) 100% braking load reduction during landing with release at touchdown (B100R). A repeated measures analysis of variance was used to determine differences of dependent variables: peak power output, peak force, peak velocity, and impulse. B100R resulted in statistically lower eccentric peak force and impulse for the first 50 milliseconds than the other 3 conditions (p < 0.05), but the largest concentric peak power. Furthermore, B0 resulted in statistically lower concentric peak power and peak velocity than the other 3 conditions (p < 0.05). We suggest that B100R was a more favorable loading condition that balanced injury risk and power production in WJS.
Hourglass-Like Constriction Neuropathy of the Upper Limb Nerve: Diffusion-Weighted Magnetic Resonance Neurography Imaging Findings

Objective The purposes of this study were to determine reliable diffusion-weighted magnetic resonance neurography (DW-MRN) features of hourglass-like constriction of the upper limb nerve and to evaluate the application value of DW-MRN compared with ultrasonography (US). Methods We retrospectively reviewed MRN studies of 13 patients. Qualitative and quantitative image analyses were carried out. The number of constrictions based on DW-MRN and US findings was compared. Results Of the 13 cases, there were 7 cases with radial nerve abnormalities, 4 with median nerve abnormalities, and 2 with radial and median nerve abnormalities. Diffusion-weighted MRN showed a single-segmental constriction in 7 of 13 cases and multisegmental constrictions in 6 of 13 cases; the hourglass-like constriction appeared in all cases (13 of 13). Thirty-three nerve constrictions were found in DW-MRN, and 29 nerve constrictions were found in US. Conclusions Diffusion-weighted MRN is a noninvasive and helpful diagnostic for hourglass-like constriction of the upper limb nerve.
Dual energy CT in pulmonary vascular disease.

Dual energy CT (DECT) imaging is a technique that extends the capabilities of CT beyond that of established densitometric evaluations. CT pulmonary angiography (CTPA) performed with dual energy technique benefits from both the availability of low kVp CT data and also the concurrent ability to quantify iodine enhancement in the lung parenchyma. Parenchymal enhancement, presented as pulmonary perfused blood volume maps, may be considered a surrogate of pulmonary perfusion. These distinct capabilities have led to new opportunities in the evaluation of pulmonary vascular diseases. Dual energy CTPA offers the potential for improvements in pulmonary emboli detection, diagnostic confidence, and most notably severity stratification. Furthermore, the appreciated insights of pulmonary vascular physiology conferred by DECT have resulted in increased use for the assessment of pulmonary hypertension, with particular utility in the subset of patients with chronic thromboembolic pulmonary hypertension. With the increasing availability of dual energy-capable CT systems, dual energy CTPA is becoming a standard-of-care protocol for CTPA acquisition in acute PE. Furthermore, qualitative and quantitative pulmonary vascular DECT data heralds promise for the technique as a "one-stop shop" for diagnosis and surveillance assessment in patients with pulmonary hypertension. This review explores the current application, clinical value, and limitations of DECT imaging in acute and chronic pulmonary vascular conditions. It should be noted that certain manufacturers and investigators prefer alternative terms, such as spectral or multi energy CT imaging. In this review the term dual energy is utilised, although readers can consider these terms synonymous for purposes of the principles explained.
MicroRNA-22 Level in Patients with Multiple Sclerosis and Its Relationship with Vitamin D and Vitamin D Receptor Levels

Introduction: Multiple sclerosis (MS) is known to be a multifactorial disorder. Numerous observational studies have suggested the implication of multiple genetic and environmental factors in the pathogenesis of MS. The aim of this work was to evaluate expression of the microRNA-22 (miRNA-22) level, in relation to vitamin D (VD) and VD receptor (VDR) levels in patients with MS during remission state. Methods: This case-control study was conducted in 50 patients with clinically definite MS and 50 age- and sex-matched healthy controls. miRNA-22 expression was assessed in both MS patients and controls using quantitative RT-PCR. The serum level of VD and VDR was assessed in both MS patients and controls using ELISA techniques. Results: The miRNA-22 level was significantly downregulated in MS patients in comparison to controls (p value <0.001). MS patients had also significantly lower VD and VDR levels in comparison to controls (p value <0.001 and <0.001, respectively). Patients with secondary progressive MS (SPMS) have a significantly higher miRNA-22 level than patients with relapsing remitting MS (RRMS) (p value = 0.042). There was a statistically significant positive correlation between the miRNA-22 level and EDSS (p value = 0.033). There was also a statistically significant positive correlation between the miRNA-22 level and VDR level (p value = 0.002). Conclusion: The miRNA-22 level was significantly downregulated in MS patients, but it had a positive correlation with disability status. Patients with SPMS have a significantly higher miRNA-22 level than patients with RRMS. VD and VDR levels were significantly lower in MS patients than controls. The miRNA-22 level was positively correlated with the VDR level.
Cucurbit[7]uril complexations of Good's buffers

The cucurbit[7]uril (CB[7]) host–guest complexations of a series of zwitterionic “Good's” biological pH buffers have been investigated in aqueous solution by means of 1H NMR spectroscopy. The cyclohexylammonium buffers bind very strongly (KCB[7] = 107 to 108 dm3 mol−1), while the morpholinium (102 to 103 dm3 mol−1) and piperazinium (103 to 104 dm3 mol−1) buffers have binding constants several orders of magnitude smaller. The binding constants increase as the distance between the ammonium and sulfonate groups increases. The pKa of 2-(cyclohexylammonio)ethanesulfonate (CHES) increases by 3.1 units upon complexation by CB[7].
Removal of line striping and shot noise from remote sensing imagery using a deep neural network with post-processing for improved restoration quality

ABSTRACT Remote sensing imagery is generally prone to various radiometric distortions such as stripe noise, line loss, line or column drop out, banding, random bad pixels i.e. shot noise. These errors arrive due to on-board anomalies. These severely degrade the radiometric quality of the measured imagery and introduce a considerable level of incorrectness. Images with such a considerable level of radiometric incorrectness cannot be used directly for any image analysis application. It needs to be analyzed and pre-processed with Image Processing techniques before going to generate the data for the use of various applications. This paper presents a global residual learning method-based deep neural network (DNN) approach to automatically remove stripe noise of various types and shot noise as well, and hence improves the image quality of remote sensing imagery. The proposed method shows improved performance in terms of Peak Signal-to-Noise Ratio (PSNR) and Structural Similarity Index Measure (SSIM) quality measures when compared with the state-of-the-art methods. In addition, destriping by residual DNN is followed by a new post-processing step using multilevel wavelet decomposition and frequency domain filtering to remove the residual striping artefacts. A global residual learning method, batch normalization, mini batch selection and skip connection steps help speeding up the training process as well as boost the network performance.
Impact of tourists’ psychological ownership of an eco-friendly trail on their behavior intention: an empirical investigation of Jeju Olle Trail in South Korea

ABSTRACT By adopting psychological ownership theory, this study examines the factors influencing trail visitors’ psychological ownership and behavioral intentions. A field survey was conducted with Korean tourists of Jeju Olle Trail, to test determining factors for psychological ownership and the role of commitment in the relationship between psychological ownership and intention to recommend. The results show that tourists’ participation and their sense of belonging were key predictors for psychological ownership. In addition, tourists’ psychological ownership had a positive influence on their commitment and intention to recommend. This study also discusses theoretical and practical implications along with suggestions for future research.
Understanding how O2O service synergies drive customer continuance intention: a study of OTAs and hotels

ABSTRACT This study broadens the understanding of how online-to-offline (O2O) service synergy enhance customer satisfaction and further drive customer continuance intention. Drawing on the self-regulatory process, halo effect, and the O2O business model, this study is the first to investigate the interconnected relationship between online service quality and the perceived value of offline services in relation to online and offline satisfaction. The findings reveal that online service quality and the perceived value of offline services are crucial antecedents of customer satisfaction, resulting in increased customer continuance intention to use online services.
Hemophagocytic lymph histiocytosis (HLH): etiologies, pathogenesis, treatment, and outcomes in critically ill patients: a review article and literature to review

ABSTRACT Hemophagocytic lymph histiocytosis (HLH) is not an independent disease but is instead a clinical syndrome that occurs in many underlying conditions involving all age groups. HLH is the consequence of a severe, uncontrolled hyperinflammatory reaction that in most cases is triggered by an infectious agent. Acquired HLH is much more common than primary HLH syndrome but primary is more fatal, and it does have the worst prognosis with no definitive treatment available to date. This review article mentioned all the latest advancements regarding etiologies, pathogenesis, treatment, and outcomes in critically ill patients who got diagnosed with HLH syndrome in last 15 years.