Miracle-dz/UniFAR-FTUs huggingface dataset:
A study of clinical and laboratory profile of dengue positive cases in hadoti region Rajasthan, India

Background: Dengue fever is one of the most common arboviral mediated outbreaks reported with increased prevalence year after year with considerable morbidity and mortality in hadoti region. the aim to study various clinical and laboratory manifestations of Dengue fever admitted in MBS Hospital KOTA, with a diagnosis of Dengue fever according to WHO protocol from December 2018 to January 2020. Methods: Prospective observational study was undertaken among adult patients. 132 patients were studied and analysed. And diagnosis was confirmed with Dengue IgM ELISA test. Other routine investigations done were routine hematological and biochemical investigations. Results: A total of 132 cases, out of which 95 cases of Dengue Fever (DF), 34 cases of dengue hemorrhagic fever and 3 cases of Dengue Shock syndrome, out of which Male: Female ratio was 2.1. and mean age of presentation was 37. Fever and myalgia were the most common finding (100%) followed by arthralgia and headache. Pruritus was found in 21 cases (15.9%) which carried a significant difference between DF and DHF (p value <0.05). Among the laboratory features, thrombocytopenia and hematocrit were found to be statistically significant in DHF patients (p value <0.05). Mean platelet count was 0.71 lakhs/mm3. Leukopenia in 40(30.3%) cases. Raised Serum Aminotransferase level, AST (>40 IU/L) was seen in 39 cases (29.54%.). Pleural effusion was seen in 4 cases (3%), of which 3 cases of DHF and 1 case of DSS. Ascites in 6 cases (4.8%), all cases belong to DHF. Gall bladder wall thickening was seen in 28 cases (21.21%) of which 20 cases (54.04%) were of DHF. Melena was the most common bleeding manifestation. Skin rash was found to be positive in 40.5% cases. Hess test was positive in 4 cases (10.8% of DHF). Conclusions: Incidence of dengue fever is on the rise in hadoti region and one of the most important differential diagnosis of patients presenting with fever during monsoon and post monsoon seasons.
Preparation of Recipient Wound Bed by Adipose Derived Stem Cell for Skin Flaps in Dogs

The aim of wound healing is to promote rapid wound closure and prevent excess scar formation. To stimulate wound healing, a variety of methods have been used, such as the topical application of herbal remedies like Aloe vera extract, the use of soft laser, natural honey and electromagnetic pulses (Houghton and Campbell, 1999). Even though good results have been achieved by these methods, the customary approach remains the International Journal of Current Microbiology and Applied Sciences ISSN: 2319-7706 Volume 9 Number 3 (2020) Journal homepage: http://www.ijcmas. com
The Effect of Implementing Safe Injection Practice Educational Program on Knowledge And Risks Control Among Nurses In Intensive Care Units

Background: Implementing safe injection practice creates the safest work environment for nurses working in intensive care units and minimizes exposure to risks. Aim: This study was carried out to evaluate the effect of implementing safe injection practice educational program on knowledge and risks control among nurses in intensive care units. Setting: study was carried out in cardiac care unit, medical, anesthesia, and neurological intensive care units at Tanta University Hospitals. Design: A quasi experimental study design was used in the present study. A purposive sample of 100 nurses who fulfilled the inclusion criteria were selected to achieve the aim of the current study. Tool I: Sociodemographic, knowledge and nurses risk assessment structure questionnaire. Tool II: Safe injection practice observational checklist. Results: All studied nurses had good total knowledge mean score level post program compare to only one quarter (25.0%) pre program. Also, positive statistically significant in total practice domains among the studied nurses post program compared to pre program p value >0.05. Conclusion: The present study found that implementing educational program was highly effective in improvement of intensive care units nurses' knowledge and practice regarding safe injection and decline risks for both nurses and patients. Recommendation: use of safety engineered syringes and good waste management during injection procedures is necessary to decline risks and ensure safety among nurses in critical care settings.
Association of Respiratory Impairment with Use of Anti-cholinesterase Pesticides in Migrant Fruit Farm Workers in Eastern Thailand

Migrant farm workers are exposed to occupational hazards in terms of exposure to pesticides containing organophosphate (OP) and carbamate (CM). In cases of mishandling of a pesticide, workers may be exposed to higher amounts of such toxic particles. Our study involved assessing factors related to respiratory disorders, including evidence of impaired lung function and respiratory system disorder symptoms (RSDS), in 274 migrant farm workers in Eastern Thailand. The experimental procedure involved interviews, as well as serum cholinesterase (SChE) and lung function assessments using a reactive paper blood test and spirometry, respectively. A multiple logistic regression analysis of independent variables and RSDS revealed an odds ratio (OR, 95% CI) of 2.787 (1.210, 6.470) in female subjects. Consumption of >4 glasses of alcohol/week and exposure to dust for >4 h/day were associated with an OR (95% CI) of 4.675 (1.395, 15.671) and 2.743 (1.238, 6.093), respectively. The multiple linear regression analysis of independent variables indicated that the SChE level, gender, age, and carrying of a sprayer were associated with as determined from the forced vital capacity (R = 0.579, R2 = 0.34; p < 0.05) and additionally associated with the forced expired volume in one second (R = 0.562, R2 = 0.315; p < 0.05). The assessment of respiratory system disorders is necessary for female farm workers who consume >3 glasses of alcohol/week, are older in age, and perform tasks that involve carrying a sprayer. Moreover, the SChE level should be routinely screened to monitor the health of migrant workers.
Platelet microRNA-15b protects against high platelet reactivity in patients undergoing percutaneous coronary intervention through Bcl-2-mediated platelet apoptosis

Background High platelet reactivity (HPR) and low platelet reactivity (LPR) are associated with an increased risk of ischemic/bleeding events in patients undergoing percutaneous coronary intervention (PCI). The role platelet miRNAs carry out in platelet reactivity regulation is largely unknown. Methods In this study, we profiled the expression pattern of platelet miRNA in patients undergoing PCI with HPR (n=4) and LPR (n=4) by miRNA microarray screening. The candidate miRNAs were further validated in a larger sample of 17 LPR and 22 HPR patients by quantitative reverse-transcription polymerase chain reaction (RT-qPCR), and miR-15b was found differentially expressed. MiR-15b mimic and inhibitor were transfected into MEG-01 cells, then Bcl-2 protein expression and cell apoptosis were assessed. The relationship between platelet reactivity and platelet apoptosis was further evaluated. ABT-737, a Bcl-2 inhibitor was used to induce platelet apoptosis in PCI patients in vitro, and the influence of enhanced platelet apoptosis on platelet reactivity was explored. Results Two miRNAs were found to be differentially expressed in patients with LPR and HPR using microarray system. Furthermore, the expression of miR-15b, a miRNA known to induce cell apoptosis via targeting of Bcl-2, was confirmed by RT-qPCR (P=0.020) to be 1.4× higher in the platelets of LPR patients than in those of HPR patients. Overexpression of miR-15b was demonstrated to suppress Bcl-2 protein expression and enhance cell apoptosis in a megakaryocyte cell line (MEG-01). The platelets of LPR patients expressed lower levels of Bcl-2 protein than those of HPR patients, and an inverse relationship between platelet reactivity and platelet apoptosis was observed among 44 patients who underwent PCI. Inducing platelet apoptosis in PCI patients in vitro, we observed that their platelet reactivity was decreased in a dose-dependent manner. Conclusions Through the promotion of platelet apoptosis, platelet miR-15b negatively regulates platelet reactivity in patients undergoing PCI. Platelet apoptosis may represent a novel antiplatelet target for overcoming HPR in PCI treatment.
Programme pluriprofessionnel de transplantation pulmonaire : impact du pharmacien clinicien dans la prise en charge thérapeutique des patients ambulatoires

La prise en charge therapeutique ambulatoire des patients transplantes pulmonaires est complexe et necessite une collaboration pluri-professionnelle dans laquelle le pharmacien clinicien a sa place. Lorsque le pharmacien clinicien detecte un probleme lie a la therapeutique medicamenteuse (PTM), il communique au prescripteur une intervention pharmaceutique (IP) pouvant entrainer une modification de la prise en charge du patient. Cette etude avait pour objectif d’evaluer retrospectivement l’impact clinique, economique et organisationnel des IP realisees de janvier 2009 a decembre 2015 par les pharmaciens cliniciens de l’hopital de jour de pneumologie du CHU Grenoble Alpes. Au total, 1569 IP ont ete recueillies dont 1449 (92,4%) ont ete acceptees par les prescripteurs. Les IP acceptees avaient un impact clinique majeur voire vital dans 7,1% des cas. Parmi les IP acceptees, 130 concernaient des interactions medicamenteuses dont 82,3% avaient un impact clinique moyen ou majeur. L’impact economique associe etait positif pour 538 IP (37,1%), nul pour 298 IP (20,6%) ou negatif pour 612 IP (42,3%). L’impact organisationnel vis-a-vis des professionnels de sante a ete evalue comme nul dans 97,6% des cas. Notre etude souligne que l’optimisation de la prise en charge therapeutique, par le pharmacien clinicien, du patient transplante pulmonaire ambulatoire a un impact clinique positif sans engendrer de surcout supplementaire. L’evaluation de l’impact des IP en routine et dans d’autres situations chroniques permettrait de mieux valoriser l’activite du pharmacien clinicien.
114PMolecular imaging with 18F-fluoroestradiol (18F-FES) to assess intra-patient heterogeneity in metastatic breast cancer (MBC): A European TRANSCAN program

4 months and median OS was 6 months. 29 patients (78%) had LM and 8 (22%) EM. 33 patients (89%) received CT: 13 (40%) Gemcitabine (GEM) plus Nab-Paclitaxel, 9 (27%) GEM in monotherapy, 7 (21%) GEM plus Erlotinib and 4 (12%) an Oxaliplatine doublet. Mean Ca 19 9 levels in patients with LM were 199349 and with EM 9107. Univariate analysis identified SIRI scores 1,9 as significant risk factor for OS. Age, sex and high CA 19,9 levels had no prognostic significance for OS in all groups. Patients with LM showed a higher SIRI than those with EM (p1⁄4 0,03). Patients with SIRI scores< 1,9 (55%) compared to those who had SIRI scores 1,9 (45%) had a longer OS (p1⁄4 0,01). LM were significantly associated with shorter OS (hazard ratio [HR] 2.79; 95% confidence interval [CI] 1.36-5.34; p1⁄4 0,002) but not those with EM (HR 1.83; CI 0.71-4.72; p1⁄4 0,2). An SIRI 1,9 resulted in a shorter OS compared to an SIRI <1,9 (HR 2.13; CI 1.10–4.10; p1⁄4 0.024).
Plant Growth Parameters in Relationship with Seed Yield of Green Gram Genotypes with Special Reference to Growing Season

Pulses are cheapest source of protein and they serve as a low cost protein to meet the needs of the large section of the people. Green gram (Vigna radiata (L.) Wilczek) is one of the important pulse crops and its seeds contain 24–26 per cent protein, 51 per cent carbohydrate, 4 per cent mineral and 3 per cent vitamins (Mondal et al., 2012). Green gram also plays vital role in fixing large amount of atmospheric nitrogen through root nodules, which helps in improving the fertility status of the soil and thereby helps the succeeding crop. In India green gram occupy an area of about 3.42 million hectares with an International Journal of Current Microbiology and Applied Sciences ISSN: 2319-7706 Volume 9 Number 3 (2020) Journal homepage: http://www.ijcmas. com
The Transition Year Programme: An Assessment

The number of students taking part in the Transition Year programme has grown significantly since the mid-1990s. However, little is known about the nature of the programme and its impact on the students who take it. This study provides a comprehensive examination of the operation of the Transition Year programme using information gathered from school principals, teachers and students themselves. The book explores the kinds of schools which provide Transition Year and the content of the programme in different school settings. It examines what school principals, teachers and students think about the programme and looks at the effect of taking part in Transition Year on a range of student outcomes, including school drop-out, subject take-up, exam performance and transitions to higher education. The book highlights 'best practice' in the operation of Transition Year and discusses the ways in which Transition Year might be developed in the future. It will be of interest to policy-makers, school management, Transition Year co-ordinators, teachers and parents.
A Survey on Various Swarm Intelligent Techniques and Applications

Swarm intelligence is an essential research field in today’s era which is being used in various applications such as image processing, signal processing, wireless sensor networks etc. swarm intelligence is mainly used to solve various optimization problems. It is the mutual comportment of decentralized and self-organized systems. Here system may refer to natural or artificial group. This paper has the main objective to do an extensive survey on various kind of swarm intelligent technique those are evolved since 1995 till date. It will also focus on various application of the swarm intelligence.
Awaiting knee joint replacement surgery: An occupational perspective on the experience of osteoarthritis

ABSTRACT Total knee replacement (TKR) is an increasingly common surgery among individuals with osteoarthritis (OA). Although the outcomes of this surgery are generally deemed positive, many are not fully satisfied with their return to pre-TKR occupations. The literature on pre-TKR occupational engagement is limited and primarily describes how the symptoms associated with OA restrict participation in occupation with little attention given to the significance occupations hold for individuals waiting for a TKR. A secondary analysis of eight purposively extracted transcripts from a primary study examining why people with OA do or do not re-engage in pre-operative occupations following hip or knee replacement was conducted. A qualitative thematic analysis approach was used to examine the pre-TKR experiences of these individuals from an occupational perspective. Three themes were identified: (1) living with OA: it is more than just the knee, (2) gradually losing my occupational identity, and (3) losing too much—a “tipping point. ” The findings suggest that the significance of lost occupations is key and unique to each individual and affects their decision for surgery.
Autoimmunity

The following article has been retracted from publication in Autoimmunity: “Drug-induced lupus erythematosus', Piercarlo Sarzi-Puttini, Fabiola Atzeni, Franco Capsoni, Ennio Lubrano & Andrea Doria. , November 2005. Autoimmunity, 38:507–518. This article has been found to reproduce content, without attribution or acknowledgement, from the following original articles: Antonov, D. , Kazandjieva, J., Etugov, D. , Gospodinov, D. , Tsankov, N. , (2004). Drug-induced Lupus Erythematosus. Clinics in Dermatology, 22, 157–166. Pramatov, K.D. , (1998). Drug-induced Lupus Erythematosus. Clinics in Dermatology, 16, 367–377. The Publishers wish to state that Autoimmunity published the article (1) in good faith, and on the basis of legal warranties made by the authors regarding the originality of their work. We welcome this opportunity to acknowledge and reinstate the rights of the original authors and the copyright of the original publishers. We note that the authors of the above mentioned article (1) have submitted a written apology.
Bone and articular cartilage tumours as seen in the Dept. of Pathology, Faculty of Medicine, Addis Ababa University

Abstract: The incidence of bone and articular cartilage tumours in Ethiopia is unknown. In those countries where incidence rates are studied, neoplasms of bone and articular cartilage are among the most uncommon of all types of tumours. To determine the relative incidence of bone and articular cartilage tumours and the distribution of specific diagnosis by age, sex and anatomic locations, a retrospective descriptive study was conducted from November 1967 to December 1996 in the Department of Pathology, Faculty of Medicine, Addis Ababa University based on surgical biopsy results. There were six hundred and eighty-nine patients; 400 (58%) had benign tumours and 289 (42%) had malignant tumours giving a benign to malignant ratio of 1.4:1. Osteochondroma was the most common benign bone tumour with 36.5% followed by chondroma (20.5%), Giant cell tumour (13.75%), Osteoma (11.5%), and others (17.75%). Osteosarcoma constitutes 35.1% of all primary malignant bone neoplasms, followed by chondrosarcoma (27.1%), Ewing’s Sarcoma (11.1%), Multiple myeloma and fibrosarcoma (8.9% each), and others (8.9%). Metastatic neoplasms are much more common than are primary malignant tumours of bone in Western English literatures. In this material metastatic neoplasms (64 cases) were preceded by osteosarcoma (79 cases). In this study, 74% of benign and 47% of malignant bone and articular cartilage tumours occurred in the age group between 10 and 29 years of age with males out numbering females in most cases. The experience insite localization of the various bone tumours in this series was in accord with that of other observers. It is hoped that the information in this study may be used as a guide to preoperative diagnosis or as a baseline for future study to see the national frequency of these tumours. [Ethiop. J. Health Dev. 1998;12(2):125-134]
Using text-based synchronous chat to offer therapeutic support to students: A systematic review of the research literature

Objective: Counselling within educational settings has now become commonplace. As with the advent of the use of new technologies in teaching, such developments are also impacting the broader support structures available to students. One development is the move of schools to offer pupils access to online counselling services. To date, such practices have received little attention, and this paper synthesises the existing empirical research literature in this area. Design: A systematic review of the literature was conducted which focused upon synchronous chat counselling for 11- to 25-year-olds. Method: Key bibliographic databases were searched for relevant papers. These were assessed for relevance and quality prior to being included into the analysis. The final selection of studies was analysed for key themes. Results: In all, 19 papers met the inclusion criteria. The thematic synthesis identified four higher order themes: (1) developing safe and youth-friendly online services, (2) online client characteristics, (3) in-session online processes and (4) session alliance and outcome. Conclusion: These themes outline the varied challenges and opportunities present within this developing practice. Each is initially discussed alongside existing literature related to online counselling before the implications for educational providers are explicitly considered. Ultimately, it is concluded that online counselling for students has much potential, however, those commissioning such services need to be mindful of common pitfalls.
Synchronous Medullary Carcinoma, Hurthle Cell Carcinoma and Parathyroid Adenoma: A Unique Case Report and Literature Review

Presently described is the case of a 68-year-old female patient who presented at a general surgery clinic with the complaint of swelling in the throat. Medullary carcinoma, Hurthle cell carcinoma, and parathyroid adenoma were detected. The patient underwent surgery and was followed-up with vitamin D and 1-thyroxine replacement therapy.
Benefits of Exercise Training For Computer-Based Staff: A Meta Analyses

Background: Office workers sit down to work for approximately 8 hours a day and, as a result, many of them do not have enough time for any form of physical exercise. This can lead to musculoskeletal discomforts, especially low back pain and recently, many researchers focused on home/office-based exercise training for prevention/treatment of low back pain among this population. Objective: This Meta analyses paper tried to discuss about the latest suggested exercises for the office workers based on the mechanisms and theories behind low back pain among office workers. Method: In this Meta analyses the author tried to collect relevant papers which were published previously on the subject. Google Scholar, Scopus, and PubMed were used as sources to find the articles. Only articles that were published using the same methodology, including office workers, musculoskeletal discomforts, low back pain, and exercise training keywords, were selected. Studies that failed to report sufficient sample statistics, or lacked a substantial review of past academic scholarship and/or clear methodologies, were excluded. Results: Limited evidence regarding the prevention of, and treatment methods for, musculoskeletal discomfort, especially those in the low back, among office workers, is available. The findings showed that training exercises had a significant effect (p<0.05) on low back pain discomfort scores and decreased pain levels in response to office-based exercise training. Conclusion: Office-based exercise training can affect pain/discomfort scores among office workers through positive effects on flexibility and strength of muscles. As such, it should be suggested to occupational therapists as a practical way for the treatment/prevention of low back pain among office workers.
Evaluating and Interpreting Epidemiological Risk

This special feature sets forth the basic skills pharmacists need to evaluate the primary literature with regard to epidemiological risk. The author discusses (1) the three key types of observational study designs used in epidemiological literature; (2) common measures of association and and their utility; (3) calculation of attributable risk, relative risk, and odds ratio; (4) the limitations of using relative risk and odds ratio; and (5) inappropriate use of risk in the primary literature.
Association between Achievement of Estimated Average Glucose Level and 6-Month Neurologic Outcome in Comatose Cardiac Arrest Survivors: A Propensity Score-Matched Analysis

We investigated whether achieving estimated average glucose (EAG) levels versus achieving standard glucose levels (180 mg/dL) was associated with neurologic outcome in cardiac arrest survivors. This single-center retrospective observational study included adult comatose cardiac arrest survivors undergoing therapeutic hypothermia (TH) from September 2011 to December 2017. EAG level was calculated using HbA1c obtained after the return of spontaneous circulation (ROSC), and the mean glucose level during TH was calculated. We designated patients to the EAG or standard glucose group according to whether the mean blood glucose level was closer to the EAG level or 180 mg/dL. Patients in the EAG and standard groups were propensity score- matched. The primary outcome was the 6-month neurologic outcome. The secondary outcomes were hypoglycemia (≤70 mg/dL) and serum neuron-specific enolase (NSE) at 48 h after ROSC. Of 384 included patients, 137 (35.7%) had a favorable neurologic outcome. The EAG group had a higher favorable neurologic outcome (104/248 versus 33/136), higher incidence of hypoglycemia (46/248 versus 11/136), and lower NSE level. After propensity score matching, both groups had similar favorable neurologic outcomes (24/93 versus 27/93) and NSE levels; the EAG group had a higher incidence of hypoglycemia (21/93 versus 6/93). Achieving EAG levels was associated with hypoglycemia but not neurologic outcome or serum NSE level.