Miracle-dz/UniFAR-FTUs huggingface dataset:
Discrepancies between Ideal and Actual Mental State at the Time of the Offense Evaluation Practices

ABSTRACT Evaluator judgments of defendants’ mental state at the time of the offense (MSO) can influence the trier of fact and have implications for fairness and justice; however, current practices, and their alignment with best practice guidelines, are effectively unknown. The limited existing literature indicates that there are some substantive differences between practice recommendations for MSO evaluations and how they are conducted in practice. The current mixed methods study expanded those findings by revealing several discrepancies among how evaluators endorsed certain collateral data sources, clinical interview topics, and psychological and forensic assessment tools in an ideal evaluation scenario and how those ratings compared to their actual practices, as well as identified the justifications provided for any discrepancies. Overall, results suggest that actual practices are generally aligned with reported ideal practices; however, some discrepancies exist. We discuss these discrepancies in relation to existing ethical and specialty guidelines and propose practice recommendations. In order to protect against potentially biasing information, evaluators are encouraged to institute safeguards when communicating with a defendant’s attorney, implement a systematic review process, and scrutinize their current clinical interviews. Additionally, clinicians should be aware of all measures relevant to the psycholegal construct and may consider requesting further data sources.
Emergent media scan of digital mutual aid organizing during the COVID-19 pandemic

ABSTRACT A rapid emergent media scan, describing 1) how mutual aid emerged as a response to COVID-19 and 2) how digital organizing was used for mutual aid, was conducted using a media bias framework to select media outlets, standardized search terms to identify relevant content, and content analysis to describe themes. A variety of digital tools (e.g., social media, crowdsourcing, video conferencing) were used to coordinate people/resources, raise funds, create connections, and educate others. Findings encourage digital organizing to meet tangible and intangible needs when formal systems fail, while carefully avoiding reifying inequities based on differential access to technology.
Discrimination Impacts Trust During Collaborative Natural Resource Governance Involving Indigenous Communities

Abstract Trust is critical to collaborative governance, including of natural resources. Existing frameworks variously emphasize the impact of individual propensity, interpersonal dynamics, and institutional characteristics on trust. However, few frameworks consider the impacts of these influences on trust simultaneously. This study uses a survey of 51 representatives of Indigenous and non-Indigenous governments from across Canada with experience in natural resource collaborations to test a multidimensional framework for trust. Results show that interpersonal influences may have a bidirectional relationship with trusting behaviors, in which constraints imposed by governments on the actions of collaborators have a mediating effect. However, only institutional influences and experiences of discrimination were observed to predict trust behaviors between collaborators. Discrimination perpetrated against Indigenous Peoples in Canada has a pervasive effect on trust in collaborative natural resource governance.
Review on tools and tool wear in EDM

Abstract Electric discharge machining (EDM) is a nontraditional machining process based on the thermal erosion of the electrically conductive workpiece and tool electrodes. The product cost manufactured by the EDM process mainly depends on the tooling cost, which comprises the cost of tool material, tool fabrication, and tool maintenance. The properties of tool material affect the machining performance parameters like material removal rate (MRR), tool wear rate (TWR), and surface roughness. The performance parameters are also influenced by the tool geometry, tool fabrication method, and the way by which both tools and workpiece interact with each other. In the EDM process, tool wear is difficult to avoid and high TWR decreases the accuracy of the machined parts. Therefore, to obtain the desired accuracy it is necessary to calculate TWR and provide wear compensation. The tool electrode fabrication method also decides the TWR. Tool electrodes are generally manufactured by metal forming techniques like forging and drawing, other than that, powder metallurgy, additive manufacturing are also being used. The process performance of the tool can be improved by cryogenic treatment and coating of the tool electrodes. This review provides the literature survey about the different types of tools used in the EDM process, methods of fabrication, tool wear types; measurement and compensation techniques.
Step by Step Water Molecule Contraction and Extension

1. PREFACE Previously one proposed the contraction 1 and the extension 2 of gaseous water molecule with the help of an exchange of the orbital energies between the bound Hydrogen and non-bound Oxygen electrons in the water molecule. In the present paper the concept is upgraded with limitations proposed to be inherent to the participants – the transmitter and the receiver –of the energy exchange. Briefly, since all the transmitted energy cannot be received, the difference should be deposited first and then raised in the reverse process. 2. THE OUTER WATER MOLECULE ELECTRONS Let us recall again the outer electron structure of water molecule 1 , 2 . It consists of four nonbound Oxygen electrons creating the negative pole as well as two bound Hydrogen electrons and two bound Oxygen electrons enabling the positive pole of the molecule as presented in Figure1 1 , 2 :
A genome-wide association study on meat consumption in a Japanese population: the Japan Multi-Institutional Collaborative Cohort study

Abstract Recent genome-wide association studies (GWAS) on the dietary habits of the Japanese population have shown that an effect rs671 allele was inversely associated with fish consumption, whereas it was directly associated with coffee consumption. Although meat is a major source of protein and fat in the diet, whether genetic factors that influence meat-eating habits in healthy populations are unknown. This study aimed to conduct a GWAS to find genetic variations that affect meat consumption in a Japanese population. We analysed GWAS data using 14 076 participants from the Japan Multi-Institutional Collaborative Cohort (J-MICC) study. We used a semi-quantitative food frequency questionnaire to estimate food intake that was validated previously. Association of the imputed variants with total meat consumption per 1000 kcal energy was performed by linear regression analysis with adjustments for age, sex, and principal component analysis components 1–10. We found that no genetic variant, including rs671, was associated with meat consumption. The previously reported single nucleotide polymorphisms that were associated with meat consumption in samples of European ancestry could not be replicated in our J-MICC data. In conclusion, significant genetic factors that affect meat consumption were not observed in a Japanese population.
Mineralization of carbon, nitrogen, phosphorus and sulphur from different organic wastes in silty clay loam soils

Mineralization of carbon, nitrogen, phosphorus and suphur was studied by incubating soil samples for 90 days at 30Â°C temperature with four different organic materials viz. Press mud, sugarcane trash, paper mill bagasse and pine needle. The results showed that the carbon mineralization in soil was significantly higher from sugarcane trash followed by press mud as compared to control. The cumulative percent of carbon mineralization increased with incubation period and maximum mineralization was recorded at 90 DOI (days after incubation). The maximum cumulative percent N-mineralization (16.88%) in soil was shown by paper mill bagasse followed by sugarcane trash and pine needle. The percent N-mineralization from all added organic amendments increased incubation period up to 45days of incubation DOI (days after incubation) after then it gradually declined, while the pine needles showed maximum cumulative P-mineralization in soil followed by sugarcane trash while minimum was recorded from press mud. The paper mill bagasse showed highest cumulative S-mineralization in soil followed by sugarcane trash. Irrespective of organic wastes, cumulative S-mineralization significantly increased after 15 days of incubation up to 45 days later on it showed declined trend. Among the organic wastes, sugarcane trash showed maximum Cmineralization in soil exhibited fast decomposition in comparison to other wastes. So, it can be used for composting.The paper mill bagasse showed more N and S mineralization while maximum mineralization of P was found in pine needle. The press mud and sugarcane trash showed potential for short duration enriched compost.
Inflammation modulates regeneration in the acute or chronically damaged zebrafish retina

Unlike mammals, zebrafish regenerate in response to retinal damage. Because microglia are activated by retinal damage, we investigated their role during regeneration following acute or chronic damage. At three weeks-post-fertilization (wpf), fish exhibiting NMDA-induced acute damage or cone photoreceptor-specific chronic degeneration, the gold rush (gosh) mutant, displayed reactive microglia and Müller glia proliferation. Retinas treated to inhibit the immune response lacked reactive microglia and possessed fewer PCNA-positive cells, while LPS treatment increased microglia and PCNA-labeled cells. NMDA-injured retinas upregulated the expression of il-1β and tnf-α pro-inflammatory cytokine genes, followed by increased expression of il-10 and arg1 anti-inflammatory/remodeling cytokine genes. An early and transiently TNF-α pro-inflammatory microglia population was identified in the NMDA-damaged retina. In contrast, gosh mutant retinas exhibited a mild increase of pro-inflammatory cytokine gene expression concurrently with a greater increased in anti-inflammatory/remodeling cytokine gene expression. Few TNF-α pro-inflammatory microglia were observed in the gosh retina. How inflammation regulates regeneration in zebrafish would provide important clues towards improving the therapeutic strategies for repairing injured mammalian tissues.
Neural Networks Implicated in Autobiographical Memory Training

Abstract Training of autobiographical memory has been proposed as an intervention to improve cognitive function. The neural substrates for such improvements are poorly understood. Several brain areas have been previously linked to autobiographical recollection, including structures in the default mode network (DMN) and the sensorimotor network. Here, we tested the hypothesis that changes in connectivity within different neural networks support distinct aspects of memory improvement in response to training on a group of 59 human subjects. We found that memory training using olfactory cues increases resting-state intranetwork DMN connectivity, and this associates with improved recollection of cue-specific memories. On the contrary, training decreased resting-state connectivity within the sensorimotor network, a decrease that correlated with improved ability for voluntary recall. Moreover, preliminary data indicate that only the decrease in sensorimotor connectivity associated with the training-induced decrease in the tumor necrosis factor α (TNFα) factor, an immune modulation previously linked to improved cognitive performance. We identified functional and biochemical factors that associate with distinct memory processes improved by autobiographical training. Pathways which connect autobiographical memory with both high-level cognition and somatic physiology are discussed.
Male White-shouldered Fairywrens (Malurus alboscapulatus) elevate testosterone when courting females but not during territorial challenges

Testosterone mediates suites of physical and behavioral traits across vertebrates, and circulation varies considerably across and within taxa. However, an understanding of the causal factors of variation in circulating testosterone has proven difficult despite decades of research. According to the challenge hypothesis, agonistic interactions between males immediately prior to the breeding season produce the highest levels of testosterone measured during this period. While many studies have provided support for this hypothesis, most species do not respond to male-male competition by elevating testosterone. As a result, a recent revision of the hypothesis (‘challenge hypothesis 2.0’) places male-female interactions as the primary cause of rapid elevations in testosterone circulation in male vertebrates. Here, we offer a test of both iterations of the challenge hypothesis in a tropical bird species. We first illustrate that male White-shouldered Fairywrens (Malurus alboscapulatus) differ by subspecies in plasma testosterone concentrations. Then we use a social network approach to find that males of the subspecies with higher testosterone are characterized by greater social interaction scores, including more time aggregating to perform sexual displays. Next, we use a controlled experiment to test whether males respond to simulated territorial intrusion or courtship interaction contexts by elevating testosterone. Males sampled during courtship had greater plasma testosterone both relative to flushed controls and males sampled during simulated intrusion. Ultimately, our results are consistent with challenge hypothesis 2.0, as males rapidly elevated testosterone following interactions with females, but not during territorial challenges.
Tonic inhibition of the chloride/proton antiporter ClC-7 by PI(3,5)P2 is crucial for lysosomal pH maintenance

The acidic luminal pH of lysosomes, maintained within a narrow range, is essential for proper degrative function of the organelle and is generated by the action of a V-type H+ ATPase, but other pathways for ion movement are required to dissipate the voltage generated by this process. ClC-7, a Cl-/H+ antiporter responsible for lysosomal Cl- permeability, is a candidate to contribute to the acidification process as part of this “counterion pathway”. The signaling lipid PI(3,5)P2 modulates lysosomal dynamics, including by regulating lysosomal ion channels, raising the possibility that it could contribute to lysosomal pH regulation. Here we demonstrate that depleting PI(3,5)P2 by inhibiting the PIKfyve kinase causes lysosomal hyperacidification, primarily via an effect on ClC-7. We further show that PI(3,5)P2 directly inhibits ClC-7 transport and that this inhibition is eliminated in a disease-causing gain-of-function ClC-7 mutation. Together these observations suggest an intimate role for ClC-7 in lysosomal pH regulation.
Uncovering expression signatures of synergistic drug response using an ensemble of explainable AI models

Complex machine learning models are poised to revolutionize the treatment of diseases like acute myeloid leukemia (AML) by helping physicians choose optimal combinations of anti-cancer drugs based on molecular features. While accurate predictions are important, it is equally important to be able to learn about the underlying molecular basis of anti-cancer drug synergy. Explainable AI (XAI) offers a promising new route for data-driven cancer pharmacology, combining highly accurate models with interpretable insights into model decisions. Due to the highly correlated, high-dimensional nature of cancer transcriptomic data, however, we find that existing XAI approaches are suboptimal when applied naively to large transcriptomic datasets. We show how a novel approach based on model ensembling helps to increase the quality of explanations. We then use our method to demonstrate that a hematopoietic differentiation signature underlies synergy for a variety of anti-AML drug combinations.
Comprehensive Analysis of Aquaporin Superfamily in Lung Adenocarcinoma

Background: Lung adenocarcinoma (LUAD) is the most predomintnt lung cancer subtype with increasing morbidity and mortality. Previous studies have shown that aquaporin (AQP) family genes were correlated with tumor progression and metastasis in several kinds of malignancies. However, their biological behaviors and prognostic values in LUAD have not been comprehensively elucidated. Methods: RNA sequencing and real-time reverse transcription PCR (RT-PCR) were used to assess AQP1/3/4/5 gene expressions in LUAD patients using GEPIA and UALCAN databases. And then Kaplan–Meier analysis, cBioPortal, Metascape, GeneMANIA, TISIDB, and TIMER were utilized to determine the prognostic value, mutation frequency, and immune cell infiltration of AQP family members in LUAD. Results: We found that AQP3 expression was significantly elevated and AQP1 expression was markedly reduced in LUAD patients, whereas the expression levels of AQP4 and AQP5 exhibited no significant changes. The Kaplan–Meier survival analysis indicated that the higher expressions of AQP1/4/5 were related to longer overall survival (OS). Of interest, AQP3 was significantly correlated with the clinical tumor stage and lower AQP3 expression showed favorable prognosis in stage I LUAD patients, which indicated that AQP3 may be a potential prognostic biomarker for patients. Through functional enrichment analysis, the functions of these four AQPs genes were mainly involved in the passive transport by aquaporins, water homeostasis, and protein tetramerization. Moreover, AQP1/3/4/5 expression was strongly associated with tumor-infiltrating lymphocytes (TILs) in LUAD. Conclusion: AQP3 can be used as a prognosis and survival biomarker for stage I LUAD. These findings may provide novel insights into developing molecular targeted therapies in LUAD.
Chinese University EFL Teachers' Perceived Support, Innovation, and Teaching Satisfaction in Online Teaching Environments: The Mediation of Teaching Efficacy

This study investigated the relationships between university EFL teachers' perceived teaching support, teacher innovation, and teaching satisfaction in online teaching environments, especially the mediating role of teaching efficacy. The results of an online questionnaire survey with 473 university EFL teachers revealed that although online peer support did not directly make any difference to teacher innovation and teaching satisfaction, greater perceived support in the form of teaching resources and teaching autonomy improved university EFL teachers' online teaching satisfaction. Online teaching efficacy significantly mediated the relationships between teaching support and teacher innovation and satisfaction. The results offer significant implications for improving the effectiveness of EFL teaching and promoting university EFL teachers' innovation and satisfaction in online teaching environments.
Molecular Epidemiology and Characteristics of CTX-M-55 Extended-Spectrum β-Lactamase-Producing Escherichia coli From Guangzhou, China

In recent years, the CTX-M-55 extended-spectrum β-lactamase (ESBL)-positive rate has gradually increased in the clinic. To identify the molecular epidemiology and characteristics of blaCTX–M–55-positive isolates, a total of 374 non-repetitive ESBL-producing Escherichia coli strains were collected from patients in two hospitals in Guangzhou, and 89 blaCTX–M–55-positive isolates were selected by CTX-M-1-group PCR amplification and confirmed by DNA sequencing. Whole-genome sequencing was used to analyze the resistance phenotype, plasmid types, phylogenetic relationships and genetic environment of the blaCTX–M–55 gene. Conjugation experiments and PCR were performed to confirm whether the plasmid harboring blaCTX–M–55 gene could be transferred. The results showed that all blaCTX–M–55-positive isolates were resistant to ceftriaxone, and 88.76 and 76.40% were resistant to ceftazidime and cefepime, respectively. The resistance rates to levofloxacin and sulfamethoxazole were 66.29 and 59.55%, respectively. However, the sensitivity rate of piperacillin/tazobactam, amoxicillin/clavulanate, and amikacin exceeded 90%. All blaCTX–M–55-positive isolates were sensitive to carbapenems. Thirty-two STs were detected in the blaCTX–M–55-positive isolates, among which the detection rate of ST1193 was relatively high (19.10%, 17/89), and other ST types were scattered. It remains to be seen whether ST1193 carrying the blaCTX–M–55 gene can become a popular clone strain in this region in the future. The plasmid types carrying the blaCTX–M–55 gene included IncI1, IncFII, IncFIC, IncFIB, IncHI2, IncI2, and IncX/Y, among which the IncI1 and IncFII plasmids were the main plasmids, accounting for 37.80 and 28.09%, respectively. Among them, 11 strains of the IncI1 plasmid existed in ST1193 strains. The blaCTX–M–55 gene was found on chromosomes of 13 isolates, and seemed to be increasing annually. Up to five distinct types of genetic environments surrounding the blaCTX–M–55 gene were analyzed. The most common structure was type II “ISEcp1-blaCTX–M–55-ORF477. ” In conclusion, whether ST1193, which carries blaCTX–M–55 gene, will be an epidemic clone of this region in the future remains to be concerned. The plasmids IncI1 and IncFII, and mobile elements such as ISEcp1 and IS26 may be the main factors leading to the spread and prevalence of CTX-M-55 genotypes.
Prevalence and Molecular Epidemiology of Transmitted Drug Resistance and Genetic Transmission Networks Among Newly Diagnosed People Living With HIV/AIDS in a Minority Area, China

Introduction: Transmitted drug resistance (TDR) can compromise antiretroviral therapy (ART) efficacy. We aimed to understand the molecular epidemiology of TDR and its genetic transmission networks among newly diagnosed people living with HIV/AIDS (PLWH). Methods: A total of 1,318 newly diagnosed PLWH, identified in all population-based HIV screening in an HIV-affected county of a minority area of China (i.e., Butuo county), were enrolled between January 1, 2018, and November 31, 2018. HIV-1 pol gene sequences were used for phylogenetic and genotypic drug resistance analyses. The genetic transmission networks were identified. Results: The prevalence of TDR among newly diagnosed PLWH was 8.12% (107/1,318). Patients in the stage of AIDS (adjusted odds ratio, OR: 2.32) and who had a history of sharing a needle ≥5 times (adjusted OR: 3.89) were more likely to have an increased risk of TDR. The prevalence of TDR for non-nucleoside reverse transcriptase inhibitors (NNRTIs) is higher than that of other inhibitors, with a relatively high prevalence of three mutations [V179D/E/DE (4.93%), K103N/KN (3.11%), and E138A/G (1.52%)]. A total of 577 (43.78%) pol sequences were involved in the genetic transmission network, with 171 clusters ranging in size from 2 to 91 pol sequences; 37.38% (40/107) of individuals carrying TDR were involved in the network, and individuals with the same TDR-associated mutations were usually cross-linked. Conclusions: Our data suggest a relatively high level of TDR and many transmission clusters among the newly diagnosed PLWH. Targeted intervention, early identification, and monitoring of resistance are warranted to reduce the TDR and prevent HIV-1 transmission in areas with a high rate of HIV-1.