Miracle-dz/UniFAR-FTUs huggingface dataset:
Mem-mEN: Predicting Multi-Functional Types of Membrane Proteins by Interpretable Elastic Nets

Membrane proteins play important roles in various biological processes within organisms. Predicting the functional types of membrane proteins is indispensable to the characterization of membrane proteins. Recent studies have extended to predicting singleand multi-type membrane proteins. However, existing predictors perform poorly and more importantly, they are often lack of interpretability. To address these problems, this paper proposes an efficient predictor, namely Mem-mEN, which can produce sparse and interpretable solutions for predicting membrane proteins with singleand multi-label functional types. Given a query membrane protein, its associated gene ontology (GO) information is retrieved by searching a compact GO-term database with its homologous accession number, which is subsequently classified by a multi-label elastic net (EN) classifier. Experimental results show that MemmEN significantly outperforms existing state-of-the-art membrane-protein predictors. Moreover, by using Mem-mEN, 338 out of more than 7,900 GO terms are found to play more essential roles in determining the functional types. Based on these 338 essential GO terms, Mem-mEN can not only predict the functional type of a membrane protein, but also explain why it belongs to that type. For the reader's convenience, the Mem-mEN server is available online at http://bioinfo.eie. polyu.edu. hk/MemmENServer/.
Adaptive evolution of molecular phenotypes

Molecular phenotypes link genomic information with organismic functions, fitness, and evolution. Quantitative traits are complex phenotypes that depend on multiple genomic loci. In this paper, we study the adaptive evolution of a quantitative trait under time-dependent selection, which arises from environmental changes or through fitness interactions with other co-evolving phenotypes. We analyze a model of trait evolution under mutations and genetic drift in a single-peak fitness seascape. The fitness peak performs a constrained random walk in the trait amplitude, which determines the time-dependent trait optimum in a given population. We derive analytical expressions for the distribution of the time-dependent trait divergence between populations and of the trait diversity within populations. Based on this solution, we develop a method to infer adaptive evolution of quantitative traits. Specifically, we show that the ratio of the average trait divergence and the diversity is a universal function of evolutionary time, which predicts the stabilizing strength and the driving rate of the fitness seascape. From an information-theoretic point of view, this function measures the macro-evolutionary entropy in a population ensemble, which determines the predictability of the evolutionary process. Our solution also quantifies two key characteristics of adapting populations: the cumulative fitness flux, which measures the total amount of adaptation, and the adaptive load, which is the fitness cost due to a population's lag behind the fitness peak.
Multi-robot sensor-based coverage path planning using capacitated arc routing approach

In this study, a novel sensor-based coverage algorithm is proposed for multi-robots considering energy capacities of the mobile robots. Firstly, the environment is modeled by a Generalized Voronoi diagram-based graph to guarantee complete sensor based coverage. Secondly, depending on required arc set, an initial complete coverage route is created by using Chinese Postman Problem (CPP) and/or Rural Postman Problem (RPP). Then this initial route is partitioned among robots using Ulusoy's algorithm, which was developed for basic capacitated arc routing (CARP), by considering robot energy capacities. Although the multi-robot sensor-based coverage problem resembles CARP, there are some differences. Therefore, Ulusoy's algorithm is modified and used for this problem. The developed algorithm is coded in C++ and implemented on P3-DX mobile robots in MobileSim simulation environment.
STAIR Vision Library (v2.5)

// perform f i l t e r i n g vector<bool> s e l e c t edFea tu r e s ; s e l e c t o r−> f i l t e r ( posFeatureVectors , negFeatureVectors , s e l e c t edFea tu r e s ) ; // trim the f e a t u r e v e c t o r s o f p o s i t i v e examples for (unsigned i = 0 ; i < posFeatureVectors . s i z e ( ) ; i++) { for ( int j = posFeatureVectors [ i ] . s i z e ( ) − 1 ; j >= 0 ; j−−) { i f ( ! s e l e c t edFea tu r e s [ j ] ) { posFeatureVectors [ i ] . e r a s e ( j ) ; } } } // do the same fo r nega t i v e examples .
Attitude determination of autonomous underwater vehicles based on pressure sensor array

Autonomous Underwater Vehicles (AUVs) are widely used in the marine exploration. Attitude determination is an important part for AUV to achieve its designed mission. This paper presents a novel sensor array constituted by four pressure sensors. Based on the theoretical analysis, the relationship between the measurements of pressure sensors and the attitudes is established. In order to verify the effectiveness of the proposed configuration, we design a multi-sensor integrated system of AUV combined with triaxial gyroscope, magnetic compass and pressure sensor array. The quaternion model and Extended Kalman filter (EKF) are selected to estimate the attitudes. The simulation results accord with the analysis to demonstrate that the proposed configuration is effective to improve the accuracy of the attitudes.
Introduction of a comprehensive management protocol for severe sepsis is associated with sustained improvements in timeliness of care and survival

Introduction Mortality from severe sepsis can be improved by timely diagnosis and treatment. This study investigates the effectiveness of a comprehensive management protocol for recognition and initial treatment of severe sepsis that spans from the emergency department (ED) to the intensive care unit. Methods Interventions included development of a management algorithm including early goal-directed therapy, a computerised physician order entry set for suspected sepsis, introduction of invasive haemodynamic monitoring and antibiotics stocked in the ED, and an extensive education campaign involving ED nurses and physicians. Main results In the 6 months after introduction of the protocol, 37 patients who had severe sepsis were identified in the ED. Compared to a randomly selected group of 37 patients who had severe sepsis and who were transferred directly to the intensive care unit before introduction of the protocol, significant improvements were observed in mean time to initiation of early goal-directed therapy (3.2 vs 10.4 h, p=0.001) and to achievement of resuscitation goals (10.4 vs 30.1 h, p=0.007). There was a trend towards more rapid administration of antibiotics (1.4 vs 2.7 h, p=0.06). This was associated with a decrease in crude hospital mortality rate from 51.4% to 27.0% (absolute risk reduction=24%, 95% CI 3% to 47%). Improvements were sustained in the follow-up audit at 16 months. Conclusions Introduction of a comprehensive management protocol to address early recognition and management of severe sepsis in the ED is associated with sustained improvements in processes of care.
Cold Pressed vs. Centrifugal Juice: Comparison in Terms of the Juice Yield, Physicochemical and Phytochemical Properties

In this study, a juice beverage was prepared from pineapple, green apple, and kiwifruit using cold press and centrifugal juice extraction methods. In the first stage, the most preferred beverage formulation (60% pineapple, 35% green apple, and 5% kiwifruit) was selected according to the acceptance index (AI) calculated based on sensory analysis scores. Next, the performance of home-type cold-pressed juicers (CPJ) and centrifugal juicers (CDJ) was compared, considering the physical, chemical, and phytochemical properties of the mixed beverage. It has been determined that the juice yield performance of the cold pressing technique is better than the centrifuge method. For example, the juice yield of pineapple obtained by a cold press juicer (92%) was found to be higher than the centrifugal extraction method (47%). Although the pH of CDJ and CPJ beverages were similar, the total soluble solids content (°Brix), the color parameters (a*, b*, L*), the browning index (BI), and the turbidity of both beverages were significantly different. While the browning index (BI), L*, and b* values of the CPJ beverage were higher, the a* value was lower than that of the CDJ beverage. Additionally, the CPJ juice mixture was more turbid and phase separation was not observed as in the CDJ beverage. This study revealed that juices obtained by both squeezing methods contained comparable total phenolic content (TPC). For example, the amount of TPC for CPJ and CDJ was 867.25 ± 0.01 mg GAE/L and 922 ± 0.01 mg GAE/L, respectively. Furthermore, the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity of both beverages was not significantly different. It was concluded that the physical properties of juices extracted by CPJ were more satisfactory than those of CDJ. However, more studies are needed to compare the data obtained on the antioxidant activity and TPC amount of fruit juices using different measurement methods.
Pleiotropic functions of a conserved insect-specific Hox peptide motif

The proteins that regulate developmental processes in animals have generally been well conserved during evolution. A few cases are known where protein activities have functionally evolved. These rare examples raise the issue of how highly conserved regulatory proteins with many roles evolve new functions while maintaining old functions. We have investigated this by analyzing the function of the `QA' peptide motif of the Hox protein Ultrabithorax (Ubx), a motif that has been conserved throughout insect evolution since its establishment early in the lineage. We precisely deleted the QA motif at the endogenous locus via allelic replacement in Drosophila melanogaster. Although the QA motif was originally characterized as involved in the repression of limb formation, we have found that it is highly pleiotropic. Curiously, deleting the QA motif had strong effects in some tissues while barely affecting others, suggesting that QA function is preferentially required for a subset of Ubx target genes. QA deletion homozygotes had a normal complement of limbs, but, at reduced doses of Ubx and the abdominal-A (abd-A) Hox gene, ectopic limb primordia and adult abdominal limbs formed when the QA motif was absent. These results show that redundancy and the additive contributions of activity-regulating peptide motifs play important roles in moderating the phenotypic consequences of Hox protein evolution, and that pleiotropic peptide motifs that contribute quantitatively to several functions are subject to intense purifying selection.
Odor-sensitive field effect transistor (OSFET) based on insect cells expressing insect odorant receptors

We here propose a completely novel bio-hybrid electronic odorant sensor, termed odor-sensitive field effect transistor (OSFET), which was developed based on insect cells expressing insect odorant receptors (ORs). Living cells of the fall armyworm (Spodoptera frugiperda: Sf21 cells) were integrated over a CMOS post-processed Al2O3 layer on extended gate terminals of a foundry-made MOSFETs. Exposure of the living cells expressing insect ORs to a specific odorant induced ion influxes, which modulated the drain current of the FET. The electrical output discriminated amongst nearly identical odorants (Δw/w = 0.85%) with high sensitivity and selectivity.
Dietary behaviours of adolescents from urban and rural areas in the district of Szamotuły--a preliminary study.

INTRODUCTION Numerous factors and conditions affect the dietary behaviours of the young population. Urban-rural differences may also influence the lifestyle of adolescents, including diet. AIM To describe dietary behaviours of two young populations: living in urban or rural areas in the district of Szamotuły (a city with a population of 19,000 inhabitants). MATERIAL AND METHODS 116 adolescents aged 15-17 years were included to this preliminary study and asked to answer questions concerning health and lifestyle. RESULTS No statistically significant difference was detected in the number of meals eaten daily, and 3 meals a day was the most frequent answer (45.9% in the rural group and 32.7% in the urban group). About 41.0% of rural subjects and 50.9% of urban ones admitted that they ate fresh fruit and vegetables every day. There was no statistically significant difference in the medium consumption frequency of fresh fruit, vegetable, fish, sweets and salty snacks. CONCLUSIONS 1. Between rural and urban adolescents no statistically significant differences were observed in dietary behaviours concerning medium number of meals eaten daily, medium frequency of fresh fruit and vegetable consumption, medium monthly frequency of fish consumption, medium weekly frequency of consumption of sweets and salty snacks. 2. More than a half of the young rural dwellers preferred more salty meals in contrast to over 56% of urban youths who preferred less salty meals. Both urban and rural adolescents most often declared that eat sweets and salty snacks daily. 3. There is a great need to change the dietary habits of teenagers, especially in avoiding an over-intake of high fat and high energy products, in order to reduce the rising prevalence of obesity among adolescents.
Task Performance Evaluation of Asymmetric Semiautonomous Teleoperation of Mobile Twin-Arm Robotic Manipulators

A series of human factors experiments involving maneuvering and grasping tasks are carried out to evaluate the effectiveness of a novel asymmetric semiautonomous teleoperation (AST) control design framework for teleoperation of mobile twin-arm robotic manipulators. Simplified configurations are examined first to explore control strategies for different aspects of such teleoperation tasks. These include teleoperation of a nonholonomic mobile base, telemanipulation of a dual-arm robot, and dual-arm/dual-operator teleoperation task scenarios. In two sets of experiments with a planar nonholonomic mobile base, teleoperation via a 3DOF planar haptic interface with position mapping and force reflection of the nonholonomic constraint decreases task-completion-time (TCT) and reduces unwanted collisions. In dual-arm and dual-operator teleoperation maneuverability experiments, the assignment of decoupled and nonconflicting control frames reduces TCT and unwanted contacts. The use of so-called "soft" constraints via passive semiautonomous control reduces TCT and unwanted block drops in telegrasping experiments with a twin-arm manipulator. A final comprehensive experiment encompassing elements of the simplified configurations demonstrates the effectiveness of AST control framework in dual-operator teleoperation of a twin-arm mobile manipulator.
Psychotic disorders in MS: Population-based evidence of an association

Administrative data from a Canadian province were accessed to assess the association of psychotic disorders with multiple sclerosis (MS). Physician-assigned ICD-9-CM codes were used to classify MS and psychotic disorder status. A significant association was observed. Additional research is needed to determine the clinical importance and treatment needs of this population.
Steady-state and stability analysis of a population balance based nonlinear ice cream crystallization model

The process of crystallization can be modelled by a population balance equation coupled with an energy balance equation. Such models are highly complex to study due to the infinite dimensional and nonlinear characteristics, especially when all the phenomena of nucleation, growth and breakage are considered. In the present paper, we have performed the stability analysis on a reduced order model obtained by the method of moments, which remains still highly complex. The considered model has been developed by the Cemagref and validated on experimental data. After computation, we get a scalar equation whose solutions correspond to the equilibrium points of the system. This equation is finally solved numerically for a concrete physical configuration of the crystallizer. We show that in most instances, there is only one steady state. The possibility of multiple steady-states is discussed.
Single source multiroute flows and cuts on uniform capacity networks

For an integer <i>h</i> ≥ 1, an <i>elementary h-route flow</i> is a flow along <i>h</i> edge disjoint paths between a source and a sink, each path carrying a unit of flow, and a single commodity <i>h-route flow</i> is a non-negative linear combination of elementary <i>h</i>-flows. An instance of a <i>single source multicommodity flow problem</i> for a graph <i>G</i> = (<i>V, E</i>) consists of a source vertex <i>s</i> ε <i>V</i> and <i>k</i> sinks <i>t</i><inf>1</inf>,. , <i>t<inf>k</inf></i> ε <i>V</i>; we denote it I = (<i>s; t</i><inf>1</inf>,., <i>t<inf>k</inf></i>). In the <i>single source multicommodity multiroute flow problem</i>, we are given an instance I = (<i>s</i>; <i>t</i><inf>1</inf>,., <i>t<inf>k</inf></i>) and an integer <i>h</i> ≥ 1, and the objective is to maximize the total amount of flow that is transferred from the source to the sinks so that the capacity constraints are obeyed and, moreover, the flow of each commodity is an <i>h</i>-route flow. We study the relation between classical and multiroute single source flows on networks with uniform capacities and we provide a tight bound. In particular, we prove the following result. Given an instance ≥ = (<i>s; t</i><inf>1</inf>,.,<i>t<inf>k</inf></i>) such that each <i>s - t<inf>i</inf></i> pair is <i>h</i>-connected, the maximum classical flow between <i>s</i> and the <i>t<inf>i</inf></i>'s is at most 2(1 - 1/<i>h</i>)-times larger than the maximum <i>h</i>-route flow between <i>s</i> and the <i>t<inf>i</inf></i>'s and this is the best possible bound for <i>h</i> ≥ 2. This, as we show, is in contrast to the situation of general multicommodity multiroute flows that are up to <i>k</i>(1 - 1/<i>h</i>)-times smaller than their classical counterparts. As a corollary, we establish a max-flow min-cut theorem for the single source multicommodity multiroute flow and cut. An <i>h-disconnecting cut</i> for I is a set of edges <i>F</i> ⊆ <i>E</i> such that for each <i>i</i>, the maximum <i>h</i>-flow between <i>s - t<inf>i</inf></i> is zero. We show that the maximum <i>h</i>-flow is within 2(<i>h</i>-1) of the mininimum <i>h</i>-disconnecting cut, independently of the number of commodities; we also describe a 2(<i>h</i> - 1)-approximation algorithm for the minimum <i>h</i>-disconnecting cut problem.
The Research for the Evaluation of Cultivated Land Quality Based on Deep Belief Networks

Traditional evaluation methods of cultivated land quality are mainly on the basis of empirical judgments in the process of weight calculation and membership determination. In this paper, taking Enshi city as an example, we attempt to employ Deep Belief Networks (DBN) to estimate the cultivated land quality. We selected 8 evaluation indexes as the input data and the grade of cultivated land as the output data to construct an evaluation model and finally realized the classification of cultivated land quality grade. Compared with the results of the Supplement and Improvement of Farmland's Classification in Enshi city 2013 in quantity and spatial distribution, our experimental results show that accuracy of grade 11, grade 12 and grade 13 in quantity reach as high as 99.06%, 90.04% and 96.07%, respectively. Besides, the spatial distribution is substantially in agreement with real distribution.
Dependence of Regioregular Poly(3-hexylthiophene) Film Morphology and Field-Effect Mobility on Molecular Weight

Morphological characterization has been used to explain the previously observed strong correlation between charge carrier mobility measured with thin-film transistors and the number-average molecular weight (MW) of the conjugated polymer regioregular poly(3-hexylthiophene). Atomic force microscopy and X-ray diffraction show that the low-mobility, low-MW films have a highly ordered structure composed of nanorods and the high-mobility, high-MW films have a less ordered, isotropic nodule structure. Modifying the morphology for a constant MW by changing the casting conditions or annealing the samples strongly affects the charge transport and morphology in the low-mobility, low-MW films, but has little effect on the high-MW films. In-plane grazing incidence X-ray scattering shows the in-plane π-stacking peak increases when the mobility increases for a constant MW. When the MW is changed, this correlation breaks down, confirming that in-plane π-stacking does not cause the mobility−MW relationship. We believe a .
Self-organizing documentary maps for information retrieval

This paper presents a neural-network-based approach for information retrieval, an important issue in natural language processing. We first describe a method for creating self-organizing documentary maps - visible and continuous representations in which all queries and documents are mapped in topological order according to their similarities. We then show that documents related to queries can be retrieved by merely calculating the Euclidean distances between the positions at which queries and documents are placed and choosing the N closest documents in the ranking order for each query. Small-scale computer experiments have demonstrated that the proposed method is capable of high precision.
Anchored conversations: chatting in the context of a document

This paper describes an application-independent tool called Anchored Conversations that brings together text-based conversations and documents. The design of Anchored Conversations is based on our observations of the use of documents and text chats in collaborative settings. We observed that chat spaces support work conversations, but they do not allow the close integration of conversations with work documents that can be seen when people are working together face-to-face. Anchored Conversations directly addresses this problem by allowing text chats to be anchored into documents. Anchored Conversations also facilitates document sharing; accepting an invitation to an anchored conversation results in the document being automatically uploaded. In addition, Anchored Conversations provides support for review, catch-up and asynchronous communications through a database. In this paper we describe motivating fieldwork, the design of Anchored Conversations, a scenario of use, and some preliminary results from a user study.
A new dual-mode model predictive control for constrained linear systems

An efficient dual mode model predictive control algorithm is proposed for time-invariant linear discrete-time systems with state and input constraints. The approach significantly enlarges the feasibility regions compared to dual mode approach. In addition, the unconstrained optimal performance for states near the origin is guaranteed. The efficacy of the approach is demonstrated via numerical example.