Miracle-dz/UniFAR-FTUs huggingface dataset:
Scientific Publishing in Information Systems

: Many academic decision makers rely on quantified ranking measures to estimate the quality of journal publications. The aim of this study was to map journals in Information Systems (IS) with regard to their topic and their rank and determine whether there is a relationship between the scope of a journal and its rank. The study used content analysis, applying both qualitative and quantitative methods. The results of the analysis show the existence of relationships between the journal rank, the research area, and the type as well as significant differences in ranking on the three lists. The findings illustrate that ranking measures, as indicators for the quality of research published in a journal ought to be considered only in the context of a particular research area and scientific community.
CMAR_A_254955 5345..5351

Yubin Hu 1 Hailan Lin Mingzhi Hao Yan Zhou Qizhong Chen Zhangxian Chen 1Department of Tumor Interventional Radiology, Fujian Cancer Hospital & Fujian Medical University Cancer Hospital, Fuzhou, Fujian Province 350014, People’s Republic of China; 2Department of Epidemiology, Fujian Cancer Hospital & Fujian Medical University Cancer Hospital, Fuzhou, Fujian Province 350014, People’s Republic of China Purpose: Unresectable intrahepatic cholangiocarcinoma (ICC) has a poor prognosis. The aim of this study was to evaluate the efficacy and safety of apatinib for patients with unresectable ICC. Patients and Methods: A total of 10 patients with unresectable ICC were enrolled for this single-center observational study between March 2, 2016, and August 27, 2019. Subjects received 500 mg apatinib on a daily basis. Tumor response was assessed by 1.1 response evaluation criteria in solid tumors. The progression-free survival (PFS) and overall survival (OS) were calculated using the Kaplan–Meier method. The drug-related adverse effects were also monitored. Results: Based on the follow-up computed tomography and magnetic resonance imaging after treatment, 4 (40.0%), 4 (40.0%), and 2 (20.0%) patients achieved a partial response, stable disease, and progression of the disease, respectively. The response rate and disease control rate were 40.0% and 80.0%, respectively. The median PFS was 4.5 months (95% confidence interval: 3.157~5.843 months); the median OS was 6.5 months (95% confidence interval: 4.744~8.256 months). Furthermore, 3-, 6-, and 9-month OS rates were 77.5%, 61.7%, and 15.0%, respectively. The most common hematologic grade 3 adverse event was neutropenia (10%); the most common nonhematologic grade 3 adverse events were hypertension (20.0%) and hand-foot syndromes (20.0%). No treatment-related grade 4 or 5 adverse events were recorded. Conclusion: Apatinib revealed to have antitumour activity in unresectable ICC patients, with manageable toxicities, and thus might be used as a new treatment option for patients with unresectable ICC.
CMAR_A_250422 3571..3578

1Orthopaedic Oncology Center, Department of Orthopedics, Changzheng Hospital, Second Military Medical University, Shanghai, People’s Republic of China; 2Department of Orthopedics, Third Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, People’s Republic of China; 3Department of Orthopedics, Taizhou People’s Hospital, Taizhou, Jiangsu Province, People’s Republic of China; 4Department of Orthopedics, Zhongnan Hospital of Wuhan University, Wuhan, Hubei Province, People’s Republic of China
The IALLT Journal C HANGES IN L EXICAL AND R EADING P ROFICIENCY T HROUGH E NGLISH I NPUT FROM V IDEO G AMES

In recent years, video games have slowly been gaining more traction as a learning tool in the academic world. Evidence has been shown that video games can be used as tools to support language acquisition. However, studies which focus on single-player games and their use outside of a classroom environment are still sparse. This paper investigates single-player video games and their effect on University student reading and vocabulary comprehension in a mixed-method study. The participants in the study included a treatment group of nine second-year university students and a control group of ten second-year university students. All the students were volunteers from the same program and came from the same university. Data taken included vocabulary size and word recognition tests followed by a reading rate and reading comprehension test. In addition to this data, qualitative data in the form of interviews were included to support the findings of the reading and vocabulary tests. Over two months, data taken from subjects suggests reading rate, reading comprehension, and word recognition speeds showed a statistically significant rise. On the other hand, vocabulary size scores showed the treatment group had lower vocabulary sizes. In addition, the diaries show evidence that repeated incidental encounters with the same word and phrase may have played a part in the above-mentioned benefits. Motivation to play the game was also upheld throughout the two months according to the qualitative data. The data suggest that certain dimensions of reading and vocabulary comprehension such as word recognition speed and Changes in Lexical and Reading Proficiency. IALLT Journal of Language Learning Technologies 28 reading speed can be developed by using video games as a learning support tool.
FREQUENTIST COVERAGE OF ADAPTIVE NONPARAMETRIC

We investigate the frequentist coverage of Bayesian credible sets in a nonparametric setting. We consider a scale of priors of varying regularity and choose the regularity by an empirical Bayes method. Next we consider a central set of prescribed posterior probability in the posterior distribution of the chosen regularity. We show that such an adaptive Bayes credible set gives correct uncertainty quantification of “polished tail” parameters, in the sense of high probability of coverage of such parameters. On the negative side, we show by theory and example that adaptation of the prior necessarily leads to gross and haphazard uncertainty quantification for some true parameters that are still within the hyperrectangle regularity scale.
GRAPHS OF CONVEX FUNCTIONS ARE σ1-STRAIGHT

A set E ⊆ Rn is s-straight for s > 0 if E has finite Method II outer s-measure equal to its Method I outer s-measure. If E is Method II s-measurable, this means E has finite Hausdorff s-measure equal to its Hausdorff s-content. The graph Γ of a convex function f : [a, b] → R is shown to be a countable union of 1-straight sets, and to contain a 1straight set maximal in the sense that its Hausdorff 1-measure equals the diameter of Γ.
Homeostasis, and Obesity IL-17 Regulates Adipogenesis, Glucose

Inﬂammatory mediators have the potential to impact a surprising range of diseases, including obesity and its associated metabolic syndrome. In this paper, we show that the proinﬂammatory cytokine IL-17 inhibits adipogenesis, moderates adipose tissue (AT) accumulation, and regulates glucose metabolism in mice. IL-17 deﬁciency enhances diet-induced obesity in mice and accelerates AT accumulation even in mice fed a low-fat diet. In addition to potential systemic effects, IL-17 is expressed locally in AT by leukocytes, predominantly by gd T cells. IL-17 suppresses adipocyte differentiation from mouse-derived 3T3-L1 preadipocytes in vitro, and inhibits expression of genes encoding proadipogenic transcription factors, adipokines, and molecules involved in lipid and glucose metabolism. IL-17 also acts on differentiated adipocytes, impairing glucose uptake, and young IL-17–deﬁcient mice show enhanced glucose tolerance and insulin sensitivity. Our ﬁndings implicate IL-17 as a negative regulator of adipogenesis and glucose metabolism in mice, and show that it delays the development of obesity. The Journal of Immunology , 2010, 185: 6947–6959. inﬂammation
Performance of the Arabic Population on the Adolescent-Adult Sensory Pro ﬁ le: An Observational Study

Background: The Adult-Adolescent Sensory Pro ﬁ le (AASP) is a questionnaire developed to measure the way in which people in different age groups respond to different sensory stimuli. These sensory stimuli may uncover different behavioral problems that may affect activities of daily living. This observational study aimed to validate the Arabic version of the AASP used to assess the sensory processing abilities of healthy individuals. Methods: Participants comprised 560 Jordanians aged 11 years and older. Participants were recruited from different community centers in Amman, Jordan during 10th March 2017 to 10th September 2017. The English version of the AASP was translated into Arabic and all participants were instructed to complete this version of the scale. Results: Internal consistency was 0.78 and 0.79 for the Arabic and the English version, respectively. The ranges of cut-off scores in the Arabic version were higher than the English version for all the quadrants of the scale. The biggest differences were found in the sensation seeking and sensory sensitivity quadrants. In certain age groups (11 – 17 and 18 – 64 years), women were more sensitive compared with men. Conclusion: The Arabic version of the AASP showed good internal consistency and can be used to assess the sensory processing abilities of healthy individuals.
Comparative Study on Toxicity of Synthetic Pyrethroids And Azadirachtin Insecticides in Experimental Rats

The current work was planned to compare the toxic effects of a commercially available insecticide (Butox 50%) that was widely used in the Egyptian veterinary field with Achook insecticide (a product of agricultural application only) derived from neem (Azadirachta indica) seed oil extract on the experimental animals in a trail to predict their side effects if used topically upon livestock and accidently ingested or licked by animal. The insecticides toxicity was evaluated on basis of signs of toxicity, changes of biochemical parameters of experimental animals in addition to histopathological findings observed in examined internal organs. Statistical analysis clarified that the total body weight of Butox 50% treated groups had a significant increase than the weight of control group. On contrary, Achook 0.15% insecticide did not have any significant effect on the body weight as weight did not changed when compared with control group. Butox 50% and Achook 0.15% insecticides caused no significant signs of toxicity or mortalities indicating high safety margin of azadirachtin on nontarget organisms. Butox 50% toxicity on overdose led to significant decrease of ALT, AST, ALP and LDH which may be a result of severe liver damage. Hypercholesterolemia was observed that may be due to the ability of pyrethroids to disrupt lipid metabolism in liver. Finally, there was a reverse relation between AChE and testosterone hormone was already observed in the results of the tested insecticides and it is worth mentioning that Achook insecticide caused the highest increase in AChE and the lowest level of testosterone hormone when compared with the control group and other insecticide groups. The histopathological examination of selected tissues showed that the safest insecticide was Achook 0.15% as it led to the least alterations in liver and kidney tissues; in addition, it did not produce any changes in histology of other organs as brain and testes unlike Butox 50% insecticide.
Physical Map of the Genome of Rhizobium meliloti 1021

A physical map of the genome of Rhizobium meliloti 1021 is presented. The physical sizes of the three replicons in this genome had previously been determined and are as follows: the chromosome, 3.4 Mb; pSym-b, 1.7 Mb; and pSym-a, 1.4 Mb. The physical maps for this GC-rich genome contain AT-rich restriction sites for Swal (5'-TAAATTTA-3'), Pacl (5'-TTAATTAA-3'), PmeI (5'-GTTTAAAC-3'), and, for pSym-b, Spel (5'ACTAGT-3'). In addition, the endonuclease I-CeuI cleaved the 23S rRNA genes in this genome, and perhaps in most eubacterial genomes. I-CeuI digestion and polymerase chain reaction amplification of rrn regions were used to determine that there are at least three rrn loci in R. meliloti, all of which are located on the chromosome. The orientation of the rrn loci was determined by Southern blotting with probes from rrn sequences located 5' and 3' to the I-CeuI site. The rrn loci are clustered in one part of the chromosome and are oriented so that transcription will occur away from a single point in the circle, as observed for the origin of replication in the Escherichia coli and Salmonella typhimurium chromosomes. Fifteen genes that had been tagged by Tn5 insertion were localized to fragments on the chromosome physical map by using the IS50 as a probe in Southern blots. In addition, glt and gap were placed on the physical map by using Southern hybridization with cloned genes. The fortuitous occurrence of a SpeI site in Tn5-233 was used to physically map 10 genetically mapped Tn5-233 integrations on pSym-b and to anchor the physical map to the genetic map. Finally, we demonstrate the usefulness of the map by localizing a total of 12 previously unmapped transposon insertions in the genome. This is the first physical map of the genome of a multireplicon member of the family Rhizobiaceae as well as the first physical map of a Rhizobium chromosome.
NDT_A_307394 1859..1868

1Unidad de Gestión Clínica de Salud Mental, Instituto de Investigación Biomédica de Málaga (IBIMA), Hospital Regional Universitario de Málaga, Málaga, 29010, Spain; 2Universidad de Málaga, Andalucía Tech, Facultad de Psicología, Málaga, 29071, Spain Purpose: Patients with severe mental disorder have health and social needs that require care. The aim of the study was to determine the main areas of perceived needs among inpatients with severe mental disorders and to identify risk factors of the group of patients with the greatest unmet needs. Patients and Methods: A total of 150 patients with severe mental illness were assessed during admission prior to discharge from the hospital. Camberwell Assessment of Needs was used as evaluation measure, in addition to clinical status (The Brief Psychiatric Rating Scale), social functioning (Personal and Social Performance) and sociodemographic variables. A descriptive and a multivariate logistic regression analysis were used to analyse variables related to the group of patients with the highest number of unmet needs (≥3). Results: Mean number of needs was 7.93, being 4.61 the mean number of needs met and 3.32 the needs unmet. The highest proportion of unmet needs were intimate relationships (44.0%), company (40.7%) and daytime activities (38.7%). A relationship was also found between the presence of three or more unmet needs and the following variables: Brief Psychiatric Rating Scale score (p=0.004), Personal and Social Performance score (p = 0.013), marital status (p=0.018), employment status (p=0.009) and voluntary admission (p=0.032). The multivariate model explained 29.5% of the variance (Nagelkerke’s R: 0.295). Conclusion: Treatments aimed at improving social relationships and daytime activities could be a good option for inpatients with many unmet needs.
Responses Unmasks IL-4 Production + Competition for Peptide in Polyclonal CD4 Cutting Edge: Lack of High Affinity

Priming of naive monoclonal CD4 T cells via weak agonsim permits GATA-3 transcription and Th2 differentiation. To test whether this process can occur in polyclonal naive populations, where a range of TCR afﬁnities exists for any given Ag/MHC complex, we primed naive CD4 cells from 5CC7 V b 3 transgenic mice, which have a ﬁxed b -chain speciﬁc for pigeon cytochrome c peptide I-E k . Priming populations depleted of higher afﬁnity, moth cytochrome c peptide I-E k tetramer-binding cells resulted in substantial IL-4 production that did not occur in the presence of higher afﬁnity cells. TCR a -chain sequence analysis showed that clones that possessed TCR features associated with high afﬁnity responses to pigeon cytochrome c made less IL-4 than clones that possessed fewer such motifs. These results indicate that cells bearing TCRs that are weakly stimulated by their cognate Ag preferentially adopt a Th2 phenotype when primed in the absence of competition from cells with higher afﬁnity receptors. The Journal of Immunology , 2010, 184: 6569–6573.
An Alternative Path to Customer Analysis

Problem: The concept of marketing segmentation was introduced over 60 years ago and have been a central element in the process of conducting customer analysis since then. However, it has barely been criticized. Consequently, companies have constructed their communication strategies upon segmentation criteria’s with the belief of it being the most effective alternative. As digitalization has changed the way in which information is retrieved and the way people communicate with one another, the customer analysis process should be adapted accordingly. Purpose: This study aimed to explore how customer analysis is performed by professionals in the marketing field today and identify which factors professionals find essential when communicating with their target audience. Method: To fulfil the purpose of this research and answer the research questions, a qualitative research approach with a case study was conducted. Semi-structured interviews with eight Swedish professionals in the field of marketing was held in the empirical data collection process. Conclusion: The analysis of the interviews showed that there is an understanding of new perspectives when conducting customer analysis among professionals today. Furthermore, acknowledgments were made that for marketing communication to be effective, changes in customer demand and individuals life context should be taken into account. Based on these results, we conclude that segmentation criteria’s might be less relevant when identifying prospects and communicating with target audiences today. Moreover, companies should become familiar with their customer's preparatory understandings, as this premise could be used as a complement to segmentation when identifying prospects and performing effective marketing communication.
An engineered IgA antibody for cancer immunotherapy

Division of Stem Cell Transplantation and Immunotherapy, 2 Department of Medicine, Christian-Albrechts-University, Schittenhelmstraße 12, 24105 Kiel, Germany Laboratory for Translational Immunology, Immunotherapy, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands Department of Biomolecular Systems, Max Planck Institute for Colloids and Interfaces, Am Mühlenberg 1 OT Golm, 14424 Potsdam, Germany Institute for Chemistry and Biochemistry, Freie Universität Berlin, 14195 Berlin, Germany Department of General Pediatrics, Christian-Albrechts-University, Schwanenweg 20, 24105 Kiel, Germany SuppreMol GmbH, Am Klopferspitz 19a, 82152 Martinsried, Germany Molecular Imaging North Competence Center, Christian-Albrechts-University, Am Botanischen Garten 14, 24118 Kiel, Germany
DMSO_A_265944 3117..3135

Department of Clinical Analysis, School of Pharmaceutical Sciences, São Paulo State University (Unesp), Araraquara, São Paulo, Brazil Introduction: Oxidative stress and exacerbated generation of advanced glycation end products (AGEs) participate in the onset of diabetic complications. Lycopene is a potent antioxidant; evidence accounts for its ability to mitigate diabetic disturbances, including the deleterious events of advanced glycation. Therefore, this carotenoid has emerged as a candidate to be used in combination with antidiabetic drugs, such as metformin, attempting to counteract the glycoxidative stress. This study investigated the effects of the treatments with lycopene or metformin, alone or in combination, on glycoxidative stress biomarkers and antioxidant defenses in diabetic rats. Methods: Streptozotocin-induced diabetic rats were treated for 35 days with lycopene (45 mg/kg) or metformin (250 mg/kg), alone or as mixtures in yoghurt. Plasma levels of glucose, triglycerides, cholesterol, thiobarbituric acid reactive substances and protein carbonyl groups (biomarkers of oxidative damage), fluorescent AGEs (biomarkers of advanced glycation), and paraoxonase 1 activity (antioxidant enzyme) were assessed. Changes in the hepatic and renal levels of glycoxidative damage biomarkers and the activities of antioxidant enzymes were investigated. Results: The combination of lycopene with metformin maintained the beneficial effects of the isolated treatments, improving the glucose tolerance and lipid profile, lessening biomarkers of oxidative damage, and increasing the paraoxonase 1 activity. Besides, the combined therapy caused further decreases in postprandial glycemia, plasma levels of cholesterol and AGEs, avoided lipid peroxidation (plasma, kidney), and increased antioxidant defenses, mainly the activity of superoxide dismutase (liver, kidney), indicating the maintenance of the lycopene effects. Conclusion: Lycopene combined with metformin may act synergistically in the control of postprandial glycemia, dyslipidemia and glycoxidative stress, as well as increased antioxidant defenses, arising as a promising therapeutic strategy to mitigate diabetic complications.
PROFITABILITAS MEMEDIASI PENGARUH STRUKTUR MODAL TERHADAP NILAI PERUSAHAAN PROPERTI YANG TERDAFTAR DI BURSA EFEK INDONESIA (BEI)

Nilai perusahaan mencerminkan kemakmuran bagi pemilik perusahaan dan menciptakan kesejahteraan bagi pemegang saham. Nilai perusahaan diperoleh dengan Price Earning Ratio (PER) dan Earning per Share (EPS) yang digunakan untuk mengetahui tingkat keuntungan suatu perusahaan terhadap per lembar sahamnya. Penelitian ini bertujuan untuk mengetahui kemampuan profitabilitas yang diperoleh dengan Return on Asset (ROA) dan Net Profit Margin (NPM) dalam memediasi pengaruh struktur modal yang diperoleh dengan Debt to Equity Ratio (DER) dan Debt to Asset Ratio (DR) terhadap nilai perusahaan. Populasi dalam penelitian ini adalah perusahaan pada sektor properti yang terdaftar di Bursa Efek Indonesia periode Tahun 2010-2014. Metode penentuan sampel dengan menggunakan metode purposive sampling, dan berdasarkan kriteria yang telah ditentukan maka didapat jumlah sampel penelitian sebanyak 8 perusahaan sampel. Data penelitian merupakan data sekunder yang diperoleh dari Indonesia Capital Market Directory periode Tahun 2010-2014. Pengujian hipotesis penelitian menggunakan alat analisis Structural Equation Model (SEM) berbasis variance-Partial Least Square (PLS) versi 2.0 M3. Hasil penelitian menunjukkan bahwa: (1) struktur modal berpengaruh positif dan signifikan terhadap profitabilitas; (2) struktur modal berpengaruh positif namun tidak signifikan terhadap nilai perusahaan; (3) profitabilitas berpengaruh positif dan signifikan terhadap nilai perusahaan; (4) profitabilitas mampu memediasi pengaruh struktur modal terhadap nilai perusahaan. Perusahaan properti di Bursa Efek Indonesia belum mencapai titik optimal pada tingkat utangnya, sehingga penambahan proporsi utang yang dapat meningkatkan profitabilitas dapat digunakan untuk mendapatkan nilai perusahaan yang lebih tinggi.
Domestic isomorphic pressures and legitimacy-seeking motivation: Implications for outward foreign direct investment of Chinese firms

Drawing on institutional theory, we argue that the likelihood of a Chinese firm adopting an isomorphic strategy in outward foreign direct investment (OFDI) depends on the influence of external isomorphic pressures (domestic regional isomorphic pressure and domestic industrial isomorphic pressure) and its internal legitimacy-seeking motivation. The analyses of 107 Chinese listed firms with 535 observations during 2008-2012 offer supportive evidence for our arguments. Our study serves to provide comprehensive insights into the motives behind the OFDI of Chinese firms and make contributions to a better understanding of regional diversity and industrial diversity in China.