Miracle-dz/UniFAR-FTUs huggingface dataset:
A 2.16-μW Low-Power Continuous-Time Delta–Sigma Modulator With Improved-Linearity Gₘ for Wearable ECG Application

This brief presents a 2.16 <inline-formula> <tex-math notation="LaTeX">$\mu \text{W}$ </tex-math></inline-formula> low-power third-order single-bit continuous-time delta-sigma modulator (CTDSM) for electrocardiogram (ECG) signal acquisition application. The proposed CTDSM uses an active-RC (A-RC) integrator as a first integrator and an improved linearized <inline-formula> <tex-math notation="LaTeX">$G_{m}$ </tex-math></inline-formula>-C integrator for the second and third integrators, respectively. The mixed-integrator structure helps to mitigate the trade-offs between power consumption and resolution. Moreover, a source-degenerated auxiliary differential pair circuit is used for the <inline-formula> <tex-math notation="LaTeX">$G_{m}$ </tex-math></inline-formula>-C integrators to improve their linearity. By using A-RC and <inline-formula> <tex-math notation="LaTeX">$G_{m}$ </tex-math></inline-formula>-C integrators together along with an improved-linearized <inline-formula> <tex-math notation="LaTeX">$G_{m}$ </tex-math></inline-formula> block, the total power consumption was measured as 2.16 <inline-formula> <tex-math notation="LaTeX">$\mu \text{W}$ </tex-math></inline-formula> with a peak signal-to-noise ratio of 80.1 dB, signal-to-noise, and distortion ratio of 78.4 dB, and a dynamic range of 81.4 dB with a bandwidth of 250 Hz. Furthermore, a real-time ECG signal was successfully captured in an ECG acquisition system that consisted a heart-rate sensor and a signal acquisition circuit, including the proposed CTDSM.
Genomic Characterization of Lactiplantibacillus plantarum Strains Possessing Differential Antiviral Immunomodulatory Activities

Lactiplantibacillus plantarum strains are used in the food industry for their probiotic properties. Some of these bacteria have immunomodulatory effects on the host and are able to improve resistance against different pathogens, including viruses. However, to date, the bacterial genes involved in the immunomodulatory effect are not known. In this work, the complete genomes of L. plantarum MPL16, CRL1506, CRL681 and TL2766 were used to perform comparative genomics with the aim of identifying the genes involved in their differential immunomodulatory effects. L. plantarum WCFS1, a strain with proven probiotic activity, was also used for comparisons. The analysis of the genes involved in the metabolic pathways of the five strains did not reveal differences in the metabolism of amino acids, lipids, nucleotides, cofactors and vitamins, nor in the genes associated with energy metabolism or the biosynthesis of lipoproteins and teichoic acids. However, differences were found between the five strains when considering carbohydrate metabolism pathways, particularly in the presence/absence of glycosylhydrolases and glycosyltransferases. In addition, a great variability was detected in the predicted surface proteins of each L. plantarum strain. These results suggest that the surface molecules expressed in the different strains of L. plantarum could be involved in their differential ability to modulate the innate antiviral immune response.
To Wait or Two Weeks: The Relationship Between Step 2 CK Scores and the Length of Dedicated Study Time Within a Longitudinal Interleaved Clerkship Curriculum

Introduction: Graduate medical education program directors report that United States Medical Licensing Examination (USMLE) Step 2 CK exam scores will likely have greater importance in the future selection of residents due to USMLE Step 1 transitioning to a pass/fail score as early as January 2022. With emphasis moving to the Step 2 exam, it is important to examine factors that maximize student Step 2 CK performance, such as third-year curriculum models and exam timing. This study analyzes whether or not Step 2 performance is affected by a specific length of dedicated study time within a Longitudinal Interleaved Clerkship (LInC) curriculum. Methods: A regression model was used to predict Step 2 scores for 102 students using previous performance measures. Actual and predicted scores were compared to indicate which students overperformed or underperformed on Step 2. A t-test was used to compare the mean difference between predicted and actual performance of students who had two weeks or less of dedicated study time for Step 2 CK versus students who had a longer dedicated study period. Results: Students who completed Step 2 with two weeks or less of dedicated study significantly overperformed (t(100)=2.06, p=0.042) on the exam (Mean=1.61, SD=9.21) compared to students who had more than two weeks of dedicated study (Mean=-1.67, SD=6.44) in a LInC curriculum. Conclusion: Although studies of Step 2 preparation time have shown the importance of taking Step 2 soon after completion of clinical rotations, this study adds a specific timeframe. Our findings show that a dedicated study period of two weeks or less for Step 2 CK within a LInC curriculum is associated with better performance. This study was limited to a LInC curriculum and may not apply to other clinical year curricula.
Early Pandemic Improvements in Diet Quality Are Associated with Increased Physical Activity and Weight Loss in US Adults

In March 2020, the COVID-19 pandemic led to restricted vocational (Voc-PA) and recreational physical activity (Rec-PA) outside of the home. We conducted a nation-wide survey in the United States (US) during the mitigation peak of the pandemic (June 2020) to assess health-related changes from the previous year. A diet quality (DQ) assessment tool weighted the relative healthfulness of eating occasions from foods prepared-at-home (Home) and away-from-home (Away). Previously-validated instruments assessed PA and demographic variables; height/weight were self-reported to calculate body mass index (BMI). T-tests explored longitudinal, between-sex, and obesity status differences in DQ, PA, and BMI; Pearson correlations explored associations. Of 1648 respondents, 814 valid responses (56.8% female, 81.7% white) were analyzed. Overall and Home DQ was higher for females than males in 2020 (p < 0.001 for both). Respondents increased DQ from 2019 to 2020, primarily from Away (p < 0.001 for both sexes). Total Rec-PA and Voc-PA was higher in males (p = 0.002, p < 0.001) than females in 2020; females reported higher other PA (p = 0.001). Change in BMI was inversely associated with change in both DQ and PA (p < 0.001 for both). In this sample of US adults, early adaptations to the COVID-19 pandemic included improved DQ and BMI. Whether these short-term improvements were maintained warrant further investigation.
Stratigraphic templates for ice core records of the past 1.5 Myr

Abstract. The international ice core community has a target to obtain continuous ice cores stretching back as far as 1.5 Myr. This would provide vital data (including a CO2 profile) allowing us to assess ideas about the cause of the Mid-Pleistocene Transition (MPT). The European Beyond EPICA project and the Australian Million Year Ice Core project each plan to drill such a core in the region known as Little Dome C. Dating the cores will be challenging, and one approach will be to match some of the records obtained with existing marine sediment datasets, informed by similarities in the existing 800 kyr period. Water isotopes in Antarctica have been shown to closely mirror deepwater temperature, estimated from Mg/Ca ratios of benthic foraminifera, in a marine core on the Chatham Rise near to New Zealand. The dust record in ice cores resembles very closely a South Atlantic marine record of iron accumulation rate. By assuming these relationships continue beyond 800 ka, our ice core record could be synchronised to dated marine sediments. This could be supplemented, and allow synchronisation at higher resolution, by the identification of rapid millennial-scale events that are observed both in Antarctic methane records and in emerging records of planktic oxygen isotopes and alkenone sea surface temperature (SST) from the Portuguese Margin. Although published data remain quite sparse, it should also be possible to match 10Be from ice cores to records of geomagnetic palaeo-intensity and authigenic 10Be/9Be in marine sediments. However, there are a number of issues that have to be resolved before the ice core 10Be record can be used. The approach of matching records to a template will be most successful if the new core is in stratigraphic order but should also provide constraints on disordered records if used in combination with absolute radiogenic ages.
Some remarkable sine and cosine functions

A record keeping and tagging system made possible by a machine readable tag implanted in an animal by a tagging gun. The tag comprises a portion which is both visually readable and machine readable, and a portion which includes barbs or spring-biased tines which lock it to the animal. The tagging gun comprises cocking means for moving the tag-like article into a firing position, releasing means for releasing the article from the cocking means, means for firing the article, and triggering means for activating the cocking means and releasing means in sequence by applying a force in a single direction. An information retrieval station features a chute with compressible sides and a weighing and measuring platform, and a machine reader which is automatically positioned with respect to the tag when the animal triggers a photoelectric sensing device, so as to read out the information coded therein while the animal is weighed and/or measured. A computer can be utilized to compare the animal's weight and measurement determined so as to further direct the processing of the animal.
Observation of Wound Healing Effect and Aesthetic Satisfaction of Patient with Second Degree Burn Wounds Treated by Kangfuxin Solution

Objective To study the effect of wound healing and aesthetic satisfaction of patient with second degree burn wounds treated by Kangfuxin solution. Methods 84 cases of burn plastic surgery in our hospital from October 2020 to October 2021 were included. All patients were randomly divided into observation group and control group with 42 cases in each group. Patients in both groups received basic treatment after admission, and patients in the control group received conventional treatment. Patients in the observation group were treated with Kangfuxin solution after admission. The clinical efficacy, wound healing time, secretion disappearance time, infection rate, and scar formation rate after treatment were compared between the two groups. The scores of patients and observer scar assessment scale (POSAS) before and after treatment were compared between the two groups, and the occurrence of adverse reactions during treatment was also compared between the two groups. Results The total effective rate of the observation group was 92.86%, which was significantly higher than that of the control group (61.90%) (P < 0.05). The time of wound healing and secretion disappearance in the observation group was significantly shorter than that in the control group (P < 0.05); the infection rate and scar formation rate in the observation group were significantly lower than those in the control group (P < 0.05). The scores of PSAs and OSAS in the observation group were significantly lower than those before treatment and after treatment in the control group (P < 0.05). There was no significant difference in the total incidence of adverse reactions between the observation group (7.14%) and the control group (9.52%) (P > 0.05). Conclusion The Kangfuxin solution has the advantages of fast wound healing, high patient satisfaction, better therapeutic effect, and high safety, which is worth clinical application.
Strategic Search: Organizational Adaptation with Competitive Positioning

In this paper, we study how competitive pressures shape organizational adaptation in complex environments with heterogeneous demand. To do so, we combine a standard NK simulation with a differentiated duopoly competition game to model firms simultaneously engaging in an internal search for superior technical proficiency and an external search for horizontally differentiated competitive positions. We show that such ‘strategic search’ limits innovation in low complexity environments, as firms sacrifice technical proficiency in order to differentiate from each other, but boosts it in high complexity environments, and examine the implications of this pattern for competitive advantage and consumer welfare. We also explore how these findings are moderated by the extent of demand heterogeneity, as well as asymmetric exposure to competition among firms. Our study integrates research on competitive positioning and organizational adaptation, contributing insights to organizational shaping, innovation, and competitive advantage. cost of innovation (and consumer surplus) in low complexity environments, but boosting innovation and consumer welfare in high complexity settings. Our study also offers new insights on competitive advantage in phase, the extent of demand heterogeneity, and whether both firms are equally susceptible to external competitive pressure. Our findings integrate demand heterogeneity and competitive dynamics into models of organizational adaptation, while contributing to work on organizational shaping, innovation, and competitive advantage.
Assessing proprioceptive acuity in people with multiple sclerosis

Background Proprioceptive acuity and impairments in proprioceptively guided reaches have not been comprehensively examined in people with multiple sclerosis (MS). Objective To examine proprioceptive acuity in people with MS who self-report and who do not self-report upper limb (UL) impairment, and to determine how people with MS reach proprioceptive targets. Methods Twenty-four participants with MS were recruited into two groups based on self-reported UL impairment: MS-R (i.e. report UL impairment; n = 12) vs. MS-NR (i.e. do not report UL impairment; n = 12). Proprioception was assessed using ipsilateral and contralateral robotic proprioceptive matching tasks. Results Participants in the MS-R group demonstrated worse proprioceptive acuity compared to the MS-NR group on the ipsilateral and contralateral robotic matching tasks. Analyses of reaches to proprioceptive targets further revealed that participants in the MS-R group exhibited deficits in movement planning, as demonstrated by greater errors at peak velocity in the contralateral matching task in comparison to the MS-NR group. Conclusion Our findings suggest that people with MS who self-report UL impairment demonstrate worse proprioceptive acuity, as well as poorer movement planning in comparison to people with MS who do not report UL impairment.
The Effect of Skin-to-Skin Contact between Father and Baby on Paternal Attachment

This study aims to determine the effect of skin-to-skin contact between father and baby within the first three hours following the childbirth on the level of paternal attachment. Data were collected from 69 fathers between May-July 2018 with Paternal Infant Attachment Scale in Antalya Medical Park Hospital in Turkey in this quasi-experimental study. Total score of the fathers who established skin-to-skin contact with the babies was 82.34±7.76, and that of the control group was 66.07±18.2 (p<0.05). Moreover, the paternal-infant attachment level of the fathers in the study group who became fathers for the first time was higher than that of the control group. The skin-to-skin contact between father and baby following childbirth was an effective practice in the transition to fatherhood.
The Morozov's principle applied to data assimilation problems

This paper is focused on the Morozov’s principle applied to an abstract data assimilation framework, with particular attention to three simple examples: the data assimilation problem for the Laplace equation, the Cauchy problem for the Laplace equation and the data assimilation problem for the heat equation. Those ill-posed problems are regularized with the help of a mixed type formulation which is proved to be equivalent to a Tikhonov regularization applied to a well-chosen operator. The main issue is that such operator may not have a dense range, which makes it necessary to extend well-known results related to the Morozov’s choice of the regularization parameter to that unusual situation. The solution which satisfies the Morozov’s principle is computed with the help of the duality in optimization, possibly by forcing the solution to satisfy given a priori constraints. Some numerical results in two dimensions are proposed in the case of the data assimilation problem for the Laplace equation.
Application of the piezoelectricity as the effective solution to energy management of the composite structures exposed to abrupt thermal load

Abstract This study pays special attention to practical solutions for declining the harmful impacts of thermal shock loading applied on the nanocomposite rectangular plate. The governing equations are obtained in the content of three-dimensional elasticity theory to establish an appropriate approach to achieving reliable results. Due to the time-dependent nature of the applied shock, it is essential to analyze the system’s transient response. Accordingly, the Laplace transform is used to set out the state-space form of the governing equations from time to the Laplace domain. The reliability of the results is verified by comparing them with those recorded in the literature.
Genotoxicity and cytotoxicity of Sambucus canadensis ethanol extract in meristem cells of Allium sativum

Sambucus canadensis is used in traditional medicine mainly in indigenous communities as an anti-inflammatory, antiviral, to treat cough, fever and other ailments, however, its use must be validated on scientific bases. The aim of this study was to evaluate the genotoxic and cytotoxic effect of the ethanol extract of Sambucus canadensis in meristem cells of Allium sativum with 5 treatments at concentrations of 125, 250, 500, 1000 and 1500 mg/L. Two thousand cells were counted per treatment; the mitotic index (MI) and nuclear abnormalities (NA) were evaluated. Data were analyzed using variance analysis (ANOVA) and Chi square (X2) (p < 0.05). Root growth was found to be inhibited based on the concentration with statistically significant differences (p < 0.05). As the dose and exposure time of the ethanol extract increased, the MI decreased. The NA increased at the highest concentrations of 500, 1000 and 1500 mg/L and these differences were statistically significant compared to the control (p = 0.001). With the results obtained, it can be shown that the species has antiproliferative effects and genotoxic activity on the Allium sativum cell cycle, which can be extrapolated to other types of eukaryotic cells. Therefore, despite being a plant with health benefits, moderate use and low concentrations are recommended to avoid harmful effects.
Antimicrobial activity of Tetraclinis articulata aerial parts essential oil from Tlemcen, Northwestern of Algeria

The essential oil from aerial parts of Tetraclinis articulata (Vahl) Masters, obtained byhydrodistillation was analyzed by GC, GC/MS and 13C-NMR and evaluated for antimicrobialactivity. The essential oil was rich in monoterpenes which α-pinene, bornyl acetate andcamphor being the main constituents.Three essential oils were tested against Staphylococcusaureus, Enterococcus faecalis, Pseudomonas aeruginosa, Escherichia coli, Klebsiellapneumoniae, Candida albicans, Aspergillus fumigatus and Aspergillus flavus and theminimum inhibitory concentration was determined.The tested oils have been shown topossess inhibitory action in the range from 1 to 6 µL/mL against Aspergillus fumigatus, A.niger and Staphylococcus aureus. However, essential oil with camphor as major componentwas the most interesting, with CMIs ranging between 1 and 3 µL/mL. While, essential oilwith α-pinene as major compound, remains the less effective, with CMIs ranging between 2and 6 µL/mL.
Construction of a membrane yeast two-hybrid library and its application in identification of PsARRO-1-interacting proteins in tree peony

ABSTRACT To investigate the molecular mechanism of the ADVENTITIOUS ROOTING RELATED OXYGENASE 1 (ARRO-1) gene in adventitious rooting of tree peony, the PsARRO-1 gene was isolated from Paeonia ostii. Subsequently, a yeast two-hybrid (Y2H) cDNA library using the split-ubiquitin yeast membrane system was constructed, the insert fragments lengths of pPR3-N membrane Y2H library were mainly concentrated between 500 and 3,000 bp, and the library capacity reached 1.3 × 107 CFUs, with an efficiency of recombinant of 100%, which met the requirements for subsequent screening of PsARRO-1-interacting proteins. Finally, 15 candidate PsARRO-1-interacting proteins were screened out by pBT3SUC-ARRO, among them potassium transporter 2, cytochrome b5 isoform E, and high mobility group B protein 3 (HMGB3) might be involved in the formation of roots. Both direct Y2H and bimolecular fluorescence complementation assays confirmed that PsARRO-1 interacted with PsHMGB3, which shared high identity with EgHMGB3 and MiHMGB3. The expression of PsHMGB3 was significantly up-regulated in the root outgrowth stage, and the overexpression of PsHMGB3 in Arabidopsis resulted in lengthened primary roots, more lateral roots. In short, the Y2H library provides a large number of useful resources for functional genomics research on roots of tree peony.
Role of IL-23 gene expression in development of psoriatic arthritis among psoriasis patients

Background: Psoriasis (PS) is an inflammatory skin disorder that lasts for a long time. About 30% of peoples with psoriatic arthritis and characterized as inflammatory arthritis that affects joints or entheses. Although there is growing evidence that interleukin-23 is a kind of interleukin that is produced by (IL-23) Signaling is important in the pathophysiology of both PS and PsA, it is unclear whether IL-23-induced skin inflammation causes joint disease. The goal of this research is to determine the expression of genes (IL-23) in PsA patients in Basrah. Material and Methods: The current study included 88 participants, 59 of whom had Poraisis (Ps), 29 of whom had Psoriatic arthritis, and 40 healthy controls (HC). From August 2020 to February 2022, samples were collected from patients at Al-Sadar Teaching Hospital and Basrah Teaching Hospital's Rheumatology Unite and Biological Therapy Center. Total RNA was collected from peripheral blood and used to evaluate the expression of the genes of interest using qRT-PCR. Results: The binding of the SYBR green dye was unique to the target genes through one peak in the melting curve data and amplification curve for the genes of interest, which included IL-23.
The X-shaped Radio Galaxy J0725+5835 is Associated with an AGN Pair

X-shaped radio galaxies (XRGs) are those that exhibit two pairs of unaligned radio lobes (main radio lobes and wings). One of the promising models for the peculiar morphology is jet reorientation. To clarify this, we conducted a 5 GHz observation with the European VLBI Network (EVN) of XRG J0725+5835, which resembles the archetypal binary active galactic nuclei (AGNs) 0402+379 in radio morphology, but it is larger in angular size. In our observation, two milliarcsecond-scale radio components with nonthermal radio emission are detected. Each of them coincides with an optical counterpart with similar photometric redshift and (optical and infrared) magnitude, corresponding to dual active nuclei. Furthermore, with the improved Very Large Array (VLA) images, we find a bridge between the two radio cores and a jet bending in the region surrounding the companion galaxy. This further supports the interplay between the main and companion galaxies. In addition, we also report the discovery of an arcsecond-scale jet in the companion. Given the projected separation of ∼100 kpc between the main and companion galaxies, XRG J0725+5835 is likely associated with a dual jetted-AGN system. In both EVN and VLA observations, we find signatures that the jet is changing its direction, which is likely responsible for the X-shaped morphology. For the origin of jet reorientation, several scenarios are discussed.