Miracle-dz/UniFAR-FTUs huggingface dataset:
Frequency and Manifestations of Autoimmunity Among Children Registered in the Kuwait National Primary Immunodeficiency Registry

Objectives: To present a prospective report on the characteristics of autoimmune manifestations in patients with primary immunodeficient children registered in the Kuwait National PIDs Registry (KNPIDR). Methods: The data were obtained from the Kuwait National Primary Immunodeficiency Disorders Registry during the period of January 2004 to December 2019. Results: A total of 286 PID children were registered in KNPIDR during the study period with a predominance of immunodeficiencies affecting cellular and humoral immunity followed by combined immunodeficiencies with associated syndromic features and diseases of immune dysregulation. Fifty-seven (19.9%) patients presented with a total of 107 autoimmune manifestations. There was no significant statistical association between autoimmune manifestations and gender. Patients with autoimmune manifestations were older at onset of PID symptoms compared to those with no such manifestations, but this did not reach level of significance. The diagnosis delay was longer in patients with autoimmune manifestations compared to those with no such manifestations (p = 0.038). Forty-seven percent of these manifestations were among the presenting symptoms while 53% were documented later during the course of the disease. Fifty-seven percent of the patients developed 1 autoimmune manifestation, 30% developed 2 such manifestations, and 16% had ≥3 autoimmune manifestations. The most common autoimmune manifestation was cytopenia, followed by gastrointestinal manifestations and manifestations of the skin, hair, and nails. Autoimmune cytopenia were more common in patients with immune dysregulation syndromes, while gastrointestinal and skin manifestations predominate in patients with immunodeficiencies affecting cellular and humoral immunity and endocrine manifestations were more common in immune dysregulation syndromes. There were significant statistical associations between developing autoimmune manifestations and death as well as PID categories, being more common in patients with immune dysregulation. The frequency of autoimmunity was high among patients with RAG, WAS, STAT5b, NF-κB2, Fas, FasL, LRBA, APECED, IL-10, and C4 deficiencies. Conclusions: Autoimmunity is frequent in patients with PIDs in Kuwait. This should prompt the suspicion of a PID in patients who present initially with autoimmunity, especially autoimmune cytopenia. Such patients should be managed with extra care since they are at a higher risk of death.
Psychogenic Non-epileptic Seizures and Pseudo-Refractory Epilepsy, a Management Challenge

Psychogenic nonepileptic seizures (PNES) are neurobehavioral conditions positioned in a gray zone, not infrequently a no-man land, that lies in the intersection between Neurology and Psychiatry. According to the DSM 5, PNES are a subgroup of conversion disorders (CD), while the ICD 10 classifies PNES as dissociative disorders. The incidence of PNES is estimated to be in the range of 1.4–4.9/100,000/year, and the prevalence range is between 2 and 33 per 100,000. The International League Against Epilepsy (ILAE) has identified PNES as one of the 10 most critical neuropsychiatric conditions associated with epilepsy. Comorbidity between epilepsy and PNES, a condition leading to “dual diagnosis,” is a serious diagnostic and therapeutic challenge for clinicians. The lack of prompt identification of PNES in epileptic patients can lead to potentially harmful increases in the dosage of anti-seizure drugs (ASD) as well as erroneous diagnoses of refractory epilepsy. Hence, pseudo-refractory epilepsy is the other critical side of the PNES coin as one out of four to five patients admitted to video-EEG monitoring units with a diagnosis of pharmaco-resistant epilepsy is later found to suffer from non-epileptic events. The majority of these events are of psychogenic origin. Thus, the diagnostic differentiation between pseudo and true refractory epilepsy is essential to prevent actions that lead to unnecessary treatments and ASD-related side effects as well as produce a negative impact on the patient's quality of life. In this article, we review and discuss recent evidence related to the neurobiology of PNES. We also provide an overview of the classifications and diagnostic steps that are employed in PNES management and dwell on the concept of pseudo-resistant epilepsy.
The MRI Features and Prognosis of Gliomas Associated With IDH1 Mutation: A Single Center Study in Southwest China

Purpose: To investigate the associations of MRI radiological features and prognosis of glioma with the status of isocitrate dehydrogenase 1 (IDH1). Material and Methods: A total of 116 patients with gliomas were retrospectively recruited from January 2013 to December 2015. All patients were undergone routine MRI (T1WI, T2WI, T2-FLAIR) scanning and contrast-enhanced MRI T1WI before surgery. The following imaging features were included: tumor location, diameter, the pattern of growth, boundary, the degree of enhancement, mass effect, edema, cross the middle line, under the ependyma. χ2 and Fisher's exact probability tests were used to determine the significance of associations between MRI features and IDH1 mutation of glioma. The survival distributions were estimated using Kaplan-Meier compared by Log-rank test. Univariate and multivariate analyses were performed using Cox regression. Results: Gliomas with IDH1 mutant were significantly more likely to exhibit homogeneous signal intensity (p = 0.009) on non-contrast MRI protocols and less contrast enhancement (p = 0.000) on contrast enhanced T1WI. IDH1 mutant type glioma was more inclined to cross the midline to invade contralateral hemisphere (p = 0.001). The overall survival between IDH1 mutated and wild type glioma were significantly different (p = 0.000), age ≤ 40 (p = 0.003), KPS scores > 80 before operation (p = 0.000) and low grade glioma (p = 0.000). Conclusions: Our results suggest IDH1 mutant in gliomas is more likely to exhibit homogeneous signal intensity, less contrast enhancement and more inclined to cross the midline. Patients with IDH1 mutated, age ≤ 40, KPS scores > 80 before operation and low-grade glioma may have a longer life and better prognosis.
Factors affecting the variation in fatty acid concentrations in lean beef from grass‐fed cattle in New Zealand and the implications for human health

Abstract Lean beef from grass‐fed cattle was analysed for fatty acid (FA) content to determine the between‐animal variation and the effects of various traits on FA composition, and indices and FA ratios that have human health implications. In Experiment 1, samples were from three muscles from five bulls, five cows, and five heifers. In Experiment 2, samples were from the m. longissimus lumborum of 50 3/4 Jersey 1/4 Limousin and 50 3/4 Limousin 1/4 Jersey cattle, born over 2 years and sired by two bulls. The heifers and steers grazed on similar pastures until slaughter. In both experiments, after adjusting for differences in total FA content of the meat, there were large coefficients of variation (CV) for trans‐vaccenic, cis‐9 trans‐11 conjugated linoleic, and docosahexaenoic acids and low CV for the saturated (SATFA) and monounsaturated FA (MUFA), and intermediate CV for other FA. There were significant effects of muscle and animal types in Experiment 1 and of breed, sire, sex, and year‐born in Experiment 2 on the composition and content of individual and groups of FA, especially the polyunsaturated FA (PUFA). The n‐6:n‐3, PUFA:SATFA, and MUFA: SATFA ratios, and the indices for atherogenicity and thrombogenicity, traits that have human health implications, were affected by factors in both experiments, but absolute differences were small. The conclusions were that the FA composition of lean grass‐fed beef could be changed by traditional means to improve the human health image of beef, but the impact would be small and progress slow. More progress was likely from selecting for beneficial FA than against undesirable SATFA.
Particulate organic matter inputs to a glacial stream ecosystem in the Swiss Alps

1. Traps for litterfall and for lateral transport of organic matter were sampled over a 1-year period along longitudinal and lateral transects in a glacial stream system (Val Roseg, Swiss Alps), which is characterized by single-thread reaches and a large subalpine floodplain. 2. Allochthonous inputs to the glacier stream were low close to the glacier terminus but increased as woody riparian vegetation and forests develop. Annual inputs varied from 0.4 g ash free dry matter (AFDM) m–2 year–1 (direct input) and 0.7 g AFDM m–2 year–1 (lateral input) in the proglacial area to 23.0 g AFDM m–2 year–1 (direct input) and 10.7 g AFDM m–2 year–1 (lateral input) in the lowest reach with adjacent subalpine forests. 3. Direct inputs of organic matter decreased exponentially from forests at the floodplain edge to the floodplain centre, while lateral inputs of organic matter correlated linearly with distance to trees. Direct litterfall dominated litter input close to the forest, while lateral transport was the major pathway for channels more than 20 m away from the forest. 4. A conceptual framework is developed illustrating the influence of terrestrial vegetation and fluvial morphology on organic matter input along the continuum of glacial streams.
Intraspecific life-history variation in Radix plicatulus (Gastropoda: Pulmonata: Lymnaeidae)

Life-histories of Radix plicatulus (Benson, 1842) populations inhabiting two neighbouring sites on a Hong Kong stream were investigated. In one of the two sites, R. plicatulus co-occurred with high densities of Pomacea levior which is known to prey on the egg capsules and hatchlings of sympatric gastropods. On the basis of general life-history theory, I hypothesized that R. plicatulus which co-occurred with P. levior should exhibit a life-history strategy characterized by a delayed reproduction, a longer recruitment period and a larger number of breeding bouts per year as compared with contemporaries inhabiting the other site with low P. levior abundance. Reproductive patterns of the two populations observed in the field accorded with the expectations of general life-history theory, and lent support to the hypothesis. However, laboratory culture experiments revealed no evidence of a genetic basis for the interpopulation differences. The importance of establishing a genetic basis for the interpopulation divergence before invoking an evolutionary explanation was discussed.
The effect of an irrigation and hydroelectric reservoir on its downstream communities

The Cernadilla reservoir, located on the River Tera (northwest Spain, Duero Basin) is an oligotrophic reservoir with a capacity of more than 250 × 106m3 and a depth of 70 m. The regulated flow pattern is characterized by higher summer flows, higher day flows than night ones, and lower weekend flows. The effects of this artificial flow regime on the stream ecosystem were evaluated by comparing the aquatic communities of an upstream station with those of three downstream stations, located at 1, 8, and 24 km from the dam. Physiocochemical characteristics of the water, fish and macrobenthic communities, and macrophytes were studied at each station. Summer water temperatures were significantly lower downstream of the reservoir. Macrophyte biomass, macrobenthic diversity, and richness were reduced below the dam. The trophic structure was changed by an increase of shredders and grazers. Fishery total biomass greatly fluctuated seasonally, but was higher above the reservoir than below it. However, in spring the trout populations were higher upstream because large numbers of spawning cyprinids from the reservoir invaded upstream reaches of the River Tera and displayed resident trout populations.
HABITAT SELECTION BY THE APHID PARASITE DIAERETIELLA RAPAE (HYMENOPTERA: BRACONIDAE) AND HYPERPARASITE CHARIPS BRASSICAE (HYMENOPTERA: CYNIPIDAE)

Abstract A suspected chemical means of habitat selection by Diaeretiella rapae, a primary parasite of aphids on crucifer plants, was investigated in the laboratory with the aid of an olfactometer. Females (and, to a lesser extent, males) were found to be attracted by odor to leaves and leaf juices of a crucifer host plant and to dilute solutions of the mustard oil allyl isothiocyanate. Given a choice of aphid colonies (Myzus persicae) on leaves of beet (Chenopodiaceae — mustard oils not present) and collard (Cruciferae — mustard oils present), female D. rapae displayed a marked preference to oviposit in aphids feeding on collard. It is concluded that female D. rapae parasites locate their hosts initially by a response to an odor emanating from the aphid host-plant, followed by visual searching. Male D. rapae were attracted by odor from female D. rapae, suggesting the existence of a sex pheromone in this species.Neither males nor females of Charips brassicae, a hyperparasite of D. rapae, were attracted to collard leaves, though females showed apparent attraction to female D. rapae. As with D. rapae, males of C. brassicae are attracted by odor to females of the same species.The host finding behavior of D. rapae is discussed in relation to that of other insect species belonging to the fauna associated with the plant family Cruciferae.
Fake News Detection via Knowledge-driven Multimodal Graph Convolutional Networks

Nowadays, with the rapid development of social media, there is a great deal of news produced every day. How to detect fake news automatically from a large of multimedia posts has become very important for people, the government and news recommendation sites. However, most of the existing approaches either extract features from the text of the post which is a single modality or simply concatenate the visual features and textual features of a post to get a multimodal feature and detect fake news. Most of them ignore the background knowledge hidden in the text content of the post which facilitates fake news detection. To address these issues, we propose a novel Knowledge-driven Multimodal Graph Convolutional Network (KMGCN) to model the semantic representations by jointly modeling the textual information, knowledge concepts and visual information into a unified framework for fake news detection. Instead of viewing text content as word sequences normally, we convert them into a graph, which can model non-consecutive phrases for better obtaining the composition of semantics. Besides, we not only convert visual information as nodes of graphs but also retrieve external knowledge from real-world knowledge graph as nodes of graphs to provide complementary semantics information to improve fake news detection. We utilize a well-designed graph convolutional network to extract the semantic representation of these graphs. Extensive experiments on two public real-world datasets illustrate the validation of our approach.
ThinGC: complete isolation with marginal overhead

Previous works on leak-tolerating GC and write-rationing GC show that most reads/writes in an application are concentrated to a small number of objects. This suggests that many applications enjoy a clear and stable clustering of hot (recently read and/or written) and cold (the inverse of hot) objects. These results have been shown in the context of Jikes RVM, for stop-the-world collectors. This paper explores a similar design for a concurrent collector in the context of OpenJDK, plus a separate collector to manage cold objects in their own subheap. We evaluate the design and implementation of ThinGC using algorithms from JGraphT and the DaCapo suite. The results show that ThinGC considers fewer objects cold than previous work, and maintaining separate subheaps of hot and cold objects induces marginal overhead for most benchmarks except one, where large slowdown due to excessive reheats is observed.
ERP

Introduction Most large companies have adopted some form of enterprise resource planning (ERP) system. A survey of IT executives in the U.S. showed that ERP was the second most important key category for investment. In many cases, the implementation of an ERP system was a long and expensive ordeal that involved extensive restructuring of businesses and reengineering of processes. While the potential benefits of ERP have been extolled frequently and much has been written about individual company experiences, only limited evidence has been produced that implementation of ERP does, on average, lead to enhanced performance. To the best of our knowledge, this is the first industry analysis on ERP because previous work has been limited to case studies and industry cross-sectional analyses. Several research studies have validated that IT provides productivity and profitability advantages. However, questions remain because it is not clear whether advantages from IT contribute, and to what degree they might contribute, to operational efficiency and profitability. For example, if the same IT is implemented by all firms in an industry, will industry profits from IT disappear? Due to the fact that for many years large companies developed their information systems independently, there have been limited opportunities to evaluate the implementation of similar IT infrastructure across companies. This study seeks to extend prior work by performing a longitudinal study of implementation of ERP systems in a specific industry. According to Porter, each industry is affected by new information technology in different ways and drawing general conclusions about how new IT affects firms across industries would be a mistake. The oil and gas industry was selected because ERP plays a major role in standardizing business processes in this industry. In this role, ERP helps firms link global operations and supply chains. Also, a commodity-product industry, like the oil and gas industry, helps us control for other influences that may have affected the performance of oil and gas companies during the study period. The ERP adopting firms are those that adopted SAP. This research applies a new methodological approach toward understanding ERP implementation because rather than looking at ordinary measures of firm performance, we look at strategic performance measures (SPM) that can only be utilized if one delves into data that is not found on the financial statements. This is the first study that shows the sources of profitability after an ERP implementation, and will help managers understand the strategic and managerial implications of ERP implementations. Our analysis compares performance changes of ERP adopting firms versus non-adopting firms over a fifteen-year period (1990--2005), which is the period when this industry was being transformed by increased use of technology in the oil and gas industry. Therefore, we see how the implementation of ERP affected firm performance during this period in relation to non-adopting firms.
Morpho-Agronomic Characterization and Evaluation of In-Country Sweet Potato Accessions in Southeastern Nigeria

The experiment was conducted in 2010 and 2011 to evaluate and characterize fifteen in-country sweet potato accessions for root characteristics and root yield, plant habits, ground cover, severity of root damage by Cylas puncticollis and Meloidogyne incognita and identify duplications. Significant differences (P<0.05) were observed for number of roots per plot, salable roots per plot, unsalable roots per plot and root yield. The highest number of roots per plot, salable roots and root tuber yield were given by E 10 , followed by B 21 while the lowest came from E 17 . The result indicated B 26 as highly susceptible to C. puncticollis , E 3 , E 11 , E 6 , E 27 and TIS 87/0087 were resistant, while B 6 , E 5 , B 2 , E 17 , B 21 , E 14 , E 7 , B 23 and E 10 were highly resistant to the pest. Seven accessions (E 5 , B 6 , B 2 , E 14 , E 7 , B 23 and E 10 ) were highly resistant, five accessions (E 3 , B 26 , E 11 , E 2 and TIS 87/0087) showed moderate resistance while B 2 , E 6 and E 17 were highly susceptible to root knot disease. Ground cover of less than 50% was identified with B 21 (erect type), the semi-erect types (E 5 , E 6 , and B 23 ) had ground cover of 50-75%, while the spreading types (B 6 , B 2 , E 11 , E 17 , E 14 and E 7 ) had 76-90% ground cover. The extremely spreading types (E 3 , B 26 and E 27 ) had more than 90% ground cover. Six accessions (E 5 , E 3 , E 6 , E 14 , B 23 and E 10 ) had white skin, seven (B 6 , B 26 , B 2 , E 27 , E 17 , E 7 and TIS 87/0087) were pale pink while two (E 11 and B 12 ) were pink. The root flesh of one accession (B 6 ) was white, three yellow, while the remaining eleven accessions were creamy, and E 27 and TIS 87/0087 were duplicates.
Anterior Cruciatel Ligament Reconstruction with Peroneus Longus Tendon Autograft: Functional Outcome and Donor Site Morbidity

Anterior Cruciate Ligament (ACL) is a knee ligament that is very important in maintaining the stability of the knee joint. The incidence of isolated ACL tears remain a common orthopaedic injury with significant increase in the rate of ACL reconstruction over time. Several types of autografts used for ACL reconstruction have some potential occurrence of donor site morbidity, including Bone-Patellar Tendon-Bone (BPTB), hamstring tendon, and quadriceps tendon. Peroneus longus tendon can be an option as a graft donor because it has biomechanical characteristics that are not significantly different from the hamstring tendon. Purpose: The aim of the study was to evaluate the functional outcome and donor site morbidity of anterior cruciate ligament (ACL) reconstruction using peroneus longus tendon autograft. Methods: This study was an observational analytical with retrospective cohort design using medical record. The functional outcomes were assessed with IKDC, Modified Cincinnati, Tegner-Lysholm, and KSS scoring system 12 months after surgery. Donor site morbidity was assessed with AOFAS and FADI scoring system, eversion strength, and plantarflexion strength. Results: Seventy five patients fulfilled the inclusion criteria (59 males and 16 females). Mean of peroneus longus tendon graft diameters were 8.39 ± 0.69 mm (range 6.5-10 mm). Significant increase of functional score (p<0.05) were found 12 months after surgery. Mean score of IKDC was 55.26 ± 12.76 preoperative; 96.69 ± 3.36 postoperative, Modified Cincinnati was 65.45 ± 16.25 preoperative; 93.29 ± 7.04 postoperative, Tegner-Lysholm was 67.80 ± 15.29 preoperative; 89.71 ± 8.35 postoperative, KSS (Knee) was 65.33 ± 19.46 preoperative; 95.17 ± 5.94 postoperative, and KSS (Function) was 76.52 ± 20.25 preoperative; 93.20 ± 10.29 postoperative. Mean score of AOFAS was 98.93 ± 3.11 and FADI was 99.80 ± 0.59 at six months after surgery. The eversion and plantarflexion strength were not significantly different (p>0.05) between donor and contralateral side ankle. There was neurapraxia in 3 (4%) patients at six months postoperative. Conclusion: The peroneus longus tendon can be an ideal source of graft for ACL reconstruction because it has good functional outcome and minimal donor site morbidity.