Miracle-dz/UniFAR-FTUs huggingface dataset:
Hemorrhagic Shock Secondary to Aortoesophageal Fistula as a Complication of Esophageal Cancer

Although aortoesophageal fistulas are rare, they can present as life-threatening emergencies. This condition can develop secondary to an aneurysm, foreign bodies, infiltrating tumors, and radiotherapy. We report a patient with hemorrhagic shock secondary to an aortoesophageal fistula. A 69-year-old male with squamous cell carcinoma of the esophagus treated with chemoradiation and metallic stent placement was admitted to the intensive care unit (ICU) after an episode of hematemesis. The patient was hemodynamically unstable, requiring fluid resuscitation, blood transfusions, and respiratory and vasopressor support. The patient developed electric pulseless activity, and cardiopulmonary resuscitation was performed for 40 minutes. An upper endoscopy showed the esophageal tumor infiltrating into the stent, and computed tomography (CT) angiogram showed leakage of contrast from the thoracic aorta to the esophagus. The diagnosis of aortoesophageal fistula was made. The patient underwent endovascular management for the fistula. However, his critical condition did not improve, and the patient perished.
INVESTIGATING THE EFFECT OF HOME CARE ON DEATH ANXIETY IN PATIENTS WITH GASTROINTESTINAL CANCER

As a chronic disease, cancer is facing a growing prevalence. Following the diagnosis of cancer in patients, complications such as crisis arousal, disruption of personal relationships, reduced self-confidence, lack of compatibility mechanisms, and readmissions can occur, which consequently bring about mental tensions in the patients and also add to the risk of depression among them. In fact, affliction with chronic diseases raises enormous needs among individuals suffering from cancer and meeting such demands will not be possible without the help and support of a healthcare team. To control psychological symptoms in such patients, pharmacological and non-pharmacological methods can be employed.
Short-term office building elevator energy consumption forecast using SARIMA

Renewable energy source integration in buildings can contribute to achieving sustainable energy use and reducing fossil fuel dependence. However, the intermittent and random nature of these energies, mainly photovoltaic and wind energy, make necessary the development of tools and strategies as forecasting to get a correct balance between demand and generation. In this paper, an energy consumption module based on the SARIMA statistical model is presented. This module is used to forecast the energy consumption of a green-elevator, which integrates photovoltaic and batteries, in different short-term time horizons. Genetic algorithms were used to speed up the optimal SARIMA model parametrization, and the chosen model was applied in a new and independent data set to test its effectiveness. Finally, the results were compared with the ANN technique and the GAM models. The SARIMA approach performed slightly better, and the best results were obtained with the time horizon of 1 h.
Bacteremia and thrombotic complications of temporary hemodialysis catheters: Experience of a single center in Morocco

Background: The use of central venous catheters is essential in hemodialysis care, but it is associated with infectious and thrombotic complications. The aim of this study is to determine rates and risk factors of hemodialysis catheter-related bacteremia and thrombotic complications from a Moroccan single center to set prevention policies. Materials and Methods: The trial was designed as a prospective observational study including all patients who required a temporary hemodialysis catheter more than 48 h. Baseline demographic and clinical data including age, sex, causes of kidney failure, comorbidities, indication for insertion, catheter insertion sites, and duration of use were collected. Patients were followed up since the insertion of catheter to its removal. Results: A total of 126 hemodialysis catheters were inserted at different sites in 93 patients for the following reasons: the absence of vascular access in patients with end-stage renal disease in 55 cases (43.65%), vascular access dysfunction or infection in 45 cases (35.71%), and acute kidney injury in 26 (20.63%). During follow-up, 15 catheters (11.9%) were complicated by bacteremia, resulting in a rate of 6.68 per 1000 catheter days. Risk factors associated with catheter-related bacteremia were diabetes (odds ratio [OR] =26.018; P = 0.017) and advanced age (OR = 1.105; P = 0.045). Causative microorganisms were dominated by coagulase-negative staphylococci in 46.66%. Twenty-four thrombotic complications (19.04%) were documented with an incidence of 10.69/1000 catheter-days. Among these complications, 18 were dysfunction of catheter (14.28%, 8.01/1000 catheter-days) and 6 were vein thrombosis (4.76%, 2.67/1000 catheter-days). Lower serum albumin levels was the unique risk factor (OR = 0.801; P = 0.042). Conclusions: Early diagnosis of chronic kidney disease and creation of arteriovenous fistula may lower the incidence of catheter use in hemodialysis.
PENGARUH PROLANIS TERHADAP TEKANAN DARAH PADA PENDERITA HIPERTENSI DI PUSKESMAS BANJARDAWA KECAMATAN TAMAN KABUPATEN PEMALANG

Hipertensi merupakan salah satu penyakit degenerative yang banyak ditemukan oleh kenaikan tekanan darah diatas normal yang diakibatkan oleh berbagai macam faktor. Terdapat beberapa penatalaksanaan bagi penderita hipertensi seperti senam, pengetahuan mengenai penatalaksanaan, pemeriksaan medis dan konsultasi kesehatan. Hal tersebut telah difasilitasi pemerintah melalui Prolanis yang dikelola BPJS. Penelitian ini bertujuan untuk mengetahui pengaruh Prolanis terhadap tekanan darah pada pasien hipertensi di puskesmas Banjardawa Kabupaten Pemalang. Rancangan penelitian ini yaitu eksperimen semu, dengan satu kelompok desain pre test dan post test. Jumlah sampel penelitian sebanyak 104 responden. Pengambilan data dilakukan oleh peneliti dengan pengukuran tekanan darah sebelum pada bulan Januari 2017 dan sesudah pada bulan maret 2017. Untuk mengetahui tingkat signifikan pengaruh Prolanis terhadap tekanan darah mengggunakan uji Wilcoxon. Hasil penelitian menunjukan rerata Tekanan Darah sebelum dilakukan Prolanis dengan hasil sistolik 155 dan diastolik 100, sedangkan rerata Tekanan Darah sesudah dilakukan Prolanis dengan hasil sistolik 130 dan diastolik 80. Hasil analisis statistic menunjukan nilai p-value = 0.000 < 0.05 sehingga dapat disimpulkan bahwa ada pengaruh Prolanis terhadap tekanan darah pada penderita hipertensi di Puskesmas Banjardawa Kabupaten Pemalang. Berdasarkan hasil penelitian tersebut maka diharapkan kepada instansi kesehatan dapat melanjutkan kegiatan Prolanis untuk menjaga stabilitas tekanan darah penderita hipertensi. Kata kunci : tekanan darah, hipertensi, prolanis
Cell-mediated immunity in Type 2 diabetes mellitus patients in diabetic ketoacidosis, patients with controlled Type 2 diabetes mellitus and healthy control subjects.

Immune modulation accompanying metabolic dysfunctio n can adversely affect outcome of a non infectious disease such as type 2 diabetes mellitus (T2DM). Peripheral T lymphocyte subsets were analyzed with monoclonal antibodies via manual count ing by the indirect immunofluorescence method, in type 2 Diabetes mellitus patients in DKA, contro lled T2DM patients as well as normal healthy contro ls (NHC). There was a significant decrease in CD4+ T ce lls alongside a non significant increase in CD8+ T cells in patients with diabetic ketoacidosis (DKA) compared to contro lled T2DM patients and normal healthy controls. Ratio of CD4/CD8+ T cells was als o lowest in DKA. These T cell changes in patients with DKA reflect an abnormal immunoregulatory mechanism in parallel with an impa ired metabolic process and may lead to enhanced beta cell damage a nd increased susceptibility to DKA crisis in T2DM patients.
Refining clustered standard errors with few clusters

We introduce efficient formulas that dramatically decrease the computational time of CR2VE and CR3VE, the cluster-robust estimators of standard errors with few clusters, and of the Imbens and Kolesar (2016) degrees of freedom. We also introduce CR3VE-λ, an estimator that is unbiased under more general conditions than CR3VE as it takes cluster unbalancedness into account. We illustrate these refinements by empirical simulations.
An exploration of student midwives' attitudes toward substance misusing women following a specialist education programme

Substance misuse is a complex issue, fraught with many challenges for those affected. Whilst the literature suggests that pregnancy may be a ‘window of opportunity’ for substance misusing women, it also suggests that there are several barriers to women engaging with health care. One of these is the fear of being judged and stigmatised by healthcare professionals, including midwives. Previous research indicates that midwives have negative regard toward substance users and that this in turn may lead to stigmatising behaviours and consequential substandard care provision. Midwives however, stress that they do not have appropriate training to be able to effectively provide appropriate care for substance misusers. Research suggests that education (formal training) is needed in this area to improve attitudes. In this study, the role of education in changing attitude toward substance use in pregnancy was explored using case study methodology. The case was a single delivery of a university degree programme distance learning module ‘Substance Misusing Parents,’ undertaken by 48 final year student midwives across 8 NHS Trusts. The research was carried out in 3 phases, using a mixture of Likert style questionnaires (Jefferson Scale of Physician Empathy and Medical Condition Regard Scale), Virtual Learning Environment discussion board qualitative data and semi structured interviews. The findings of the questionnaires showed that whilst general empathy levels showed no significant change (p=0.539), empathy toward pregnant drug using women showed a statistically significant improvement following the module (p=0.012). Furthermore, exploration of the students’ experiences of the module demonstrated the importance of sharing and reflecting on practice with peers; the experiences of drug users, both positive and negative; and having an opportunity to make sense of these experiences, thus bridging the ‘theory-practice divide,’ as key in influencing their views. Furthermore the findings indicated value in the mode of delivery of such education, suggesting e-learning to be an effective approach, offering not only knowledge gain in terms of the content, but in wider research and critical thinking skills. This research demonstrates the potential of education in this area but also offers suggestions for effective methods of educational delivery to potentially help reduce stigma in other areas of practice.
Biomarker findings and mature clinical results from KEYNOTE-052: First-line pembrolizumab (pembro) in cisplatin-ineligible advanced urothelial cancer (UC).

4502Background: Comorbidities and renal impairment preclude many with advanced UC from receiving chemotherapy. Initial results from the phase 2 KEYNOTE-052 (NCT02335424) trial suggested first-line pembro is active and safe in cisplatin-ineligible advanced UC. We present updated efficacy and safety data (all pts have ≥6 mo follow-up) and evaluate biomarkers correlated with outcomes. Methods: Eligibility criteria included cisplatin-ineligible (ECOG PS 2, CrCl ≥30- < 60 mL/min, grade ≥2 neuropathy/hearing loss, NYHA Class 3 heart failure), advanced UC, and no prior systemic chemotherapy. Pts received pembro 200 mg IV Q3W. Imaging was performed at wk 9, then Q6W for the first year, and Q12W thereafter. Primary end point was confirmed ORR (RECIST v1.1, independent review). Efficacy and safety were assessed in the 370 pts with ≥1 pembro dose. The associations of an 18-gene expression profile (GEP) and IHC PD-L1 combined positive score (CPS) with ORR were evaluated. Results: As of the Dec 19, 2016, data cutoff, .
Three‐Dimensional Mapping of Mt. Ruapehu Volcano, New Zealand, From Aeromagnetic Data Inversion and Hyperspectral Imaging

Combining 3‐D inversion of high‐resolution aeromagnetic data with airborne hyperspectral imaging creates a new method to map buried structure and hydrothermal alteration, applied to Mt. Ruapehu volcano, New Zealand. Hyperspectral imaging is sensitive to surface mineralogy including alteration minerals, while magnetic vector inversion reveals the volumetric distribution of magnetic susceptibility from which we interpret buried geology. Probability assessment from multiple model regularizations provides an important model uncertainty estimate. At Ruapehu, hyperspectral imaging highlights two main regions of surface alteration: the Pinnacle Ridge and the southeast flanks. The magnetic model of Pinnacle Ridge shows that alteration seen at surface continues to depth, but strongly magnetic, unaltered dikes form the core of the ridge. On the southeast flanks, the magnetic model also shows alteration imaged on the surface continues to depth; however, a previously unknown, magnetized sill intrudes part of the flank. Several smaller demagnetized regions are modeled, unlike at neighboring Mt. Tongariro where the hydrothermal system created a large demagnetized core. We propose that these differences relate to spatially focused (Ruapehu) vs distributed (Tongariro) eruption vents, the degree of faulting of the edifice and its glaciation history. Lava‐ice interaction produces fine‐grained lavas with measured magnetic susceptibilities similar to some moderately altered lavas, illustrating that care must be taken in the interpretation of magnetic data in the absence of geological information. The combination of hyperspectral imaging and aeromagnetic data inversion distinguishes shallow surface weathering from deeper‐seated hydrothermally altered rock masses, with implications for the magnitude and probability of collapse events.
A Database Optimization Strategy for Massive Data Based Information System

— With the rapid arrival of the information explosion era, the amount of data stored in a single table of an enterprise information management system is getting more and more common. Therefore, efficiency optimization of SQL based on the massive data is an essential task to break the bottleneck in current enterprise information management systems. This paper proposes single table optimization methods for massive database. These methods including: physical optimization, index optimization and query statement optimization. Each optimization method is integrated into the database design process, and a set of optimization programs for the massive database design process is proposed. In the test environment, the size of the databases file is over 200G and single table records is over 80 million, the proposed optimization methods break the bottleneck of query efficiency and improve the database query efficiency of tens of times.
Deep Learning for Dynamic Music Generation

In the last decade, Deep Learning (DL) algorithms have been increasing their popularity in several fields such as computer vision, speech recognition, natural language processing and many others. DL models, however, are not limited to scientific domains as they have recently been applied to content generation in diverse art forms both in the generation of novel content and as co-creative tools. Artificial music generation is one of the fields where DL architectures have been applied. They have been mostly used to create new compositions exhibiting promising results when compared to human compositions. Despite this, the majority of these artificial pieces lack some expression when compared to music compositions performed by humans. In this document, we propose a system capable of artificially generating expressive music compositions. Our main goal is to improve the quality of the musical compositions generated by the artificial system by exploring perceptually relevant musical elements such as note velocity and duration. To assess this hypothesis we perform user tests. Our results suggest that expressive elements such as duration and velocity are key aspects in a music composition, making the ones that include these preferable to non-expressive ones.
Business continuity, motivation, and social conditions of young entrepreneurs

DOI: 10.14254/2071789X.2019/12-4/10 ABSTRACT. The insignificant amount of Indonesian youths engaging in entrepreneurship has led to the assumption that it is difficult for youths to become entrepreneurs for their lack of capacity to create and innovate, and also their lack of courage to take risks. As a result, there is nearly no study on the capacity of young Indonesian entrepreneurs in maintaining their business continuity. This qualitative research, thus, aims to explore – by using the narrative method – the experiences of six young entrepreneurs in Indonesia when they were in a condition to decide to become an entrepreneur, and the conditions of running a business, with the purpose of understanding the context in which the youths opt to maintain business continuity. The study results indicate that despite being committed to themselves, their businesses, and their social capital, the youths’ motivation to maintain their business continuity varies. More dynamic social conditions and more social relations result in more successful business continuity for it is driven by more superior motivation of young entrepreneurs; conversely, if social conditions are merely formed by internal conditions and fewer social relations, then youths’ motivation to continue their business is low.
Effect of Fasting Blood Glucose (FBG) on Lipid Metabolism and Gender Differences in the Pattern of Dyslipidemia in Adults with Type 2 Diabetes in Northern India

ABSTRACT The present study aims to explore the effect of hyperglycemia on lipid profile components of type 2 diabetes patients and to evaluate the gender differences in the lipid abnormalities in type 2 diabetes. A total of 680 diabetic patients (340 males and 340 females) with fasting blood glucose level (fasting glucose <126 mg/dl and with fasting blood glucose ≥126 mg/dl) were analyzed for serum triglycerides, total cholesterol, LDL, HDL and VLDL. The patients who had one or more parameters (TG, HDL or LDL) outside the targets recommended by American Diabetes Association (ADA) were considered to have dyslipidemia. The subjects with fasting blood glucose (FBG) ≥126 mg/dl had more deranged levels of lipid profile components and there was a positive significant correlation of FBG with TG (r=0.3), TC (r=0.3), HDL (r=0.2), LDL (r=0.2) and VLDL (r=0.2). The prevalence of dyslipidemia in males and females were 97.6 percent and 89.9 percent, respectively. Combined dyslipidemia with high LDL and high TG was the most common pattern among males and isolated high LDL among females, contributing to 43.8 percent and 18.2 percent of patients with dyslipidemia, respectively. Dyslipidemia is the commonest complication of diabetes mellitus and the patients with high FBG had more deranged lipid values indicating that poor glycemic control is associated with abnormal lipid profile.
Clinical Case of Bilateral Rupture of the Patellar Tendon of the Late Diagnosis

Defined as a continuity solution on the muscular-osseous-tendinous chain of the knee, ensuring the extension of the leg on the thigh, the traumatic rupture of the knee’s extensor apparatus is often reported in literature. They are dominated by patellar fractures. The patellar or quadricipital tendon damage is rare and even exceptional in a bilateral topography. The aim of this work was to highlight the clinical case of bilateral rupture of the patellar tendon of late diagnosis, occurring in an adult with a particular field. It was an adult, who presented a bilateral rupture of the knee extensor apparatus following a minimal traumatism. Anamnesis found a chronic kidney disease correctly follow-up. The diagnosis was delayed so was the surgical management (Krackow’s technique and protection by a metallic frame). At 8 months post surgery the functional result is acceptable. The bilateral rupture of the patellar tendon stays a rare pathologic entity, which always seems associated at a particular field. The diagnosis delay (and so did the care) is an important bad prognosis factor. Treatment of this old form (unknown) is exclusively surgical.
A Scalable and Energy-Efficient Concurrent Binary Search Tree With Fatnodes

In the recent past, devising algorithms for concurrent data structures has been driven by the need for scalability. Further, there is an increased traction across the industry towards power efficient concurrent data structure designs. In this context, we introduce a scalable and energy-efficient concurrent binary search tree with fatnodes (namely, FatCBST), and present algorithms to perform basic operations on it. Unlike a single node with one value, a fatnode consists of a set of values. FatCBST minimizes structural changes while performing update operations on the tree. In addition, fatnodes help to exploit the spatial locality in the cache hierarchy and also reduce the height of the tree. FatCBST allows multiple threads to perform update operations on an existing fatnode simultaneously. Experimental results show that for low contention workloads as well as large set sizes, FatCBST scales well and also provides high performance-per-watt values as compared to the state-of-the-art implementations. For high contention workloads with small set sizes, FatCBST suffers from contention.
Why Do Veterinary Pathologists Attend CPD Events?

Abstract Continuing professional development (CPD) is essential for veterinary pathologists and participation is encouraged. The Charles Louis Davis and Samuel Wesley Thompson DVM Foundation organizes the annual Davis Thompson Foundation European Symposia (DTFES). An online questionnaire was sent to 446 previous delegates. Sixty-three delegates responded giving a response rate of 14.12%. The key conclusions were that the conference topic, reputation of speakers, cost and the chance to network were the most important attendance factors. The conference social events, tourist attractions of the conference host city, and scheduling were the least important attendance factors.
Effect of ultrasonic-assisted extraction on the properties, antioxidant and inflammatory activities of carotenoids from gac (Momordica cochinchinensis) fruit pericarp

Abstract This study investigated the effects of ratio of ethanol to water (green solvent), extraction temperature and reaction time on properties of carotenoids ultrasonically extracted from pericarp of gac fruit. The solvent ratio and temperature significantly affected the antioxidant activity and carotenoid contents. Ultrasonic-assisted extraction (UAE) with absolute ethanol at 75°C for 15 min produced the extract with the highest antioxidant activity and carotenoid level similar to the extract extracted for 30 min. This extract consisted of lycopene, β-carotene, and lutein, as confirmed by HPLC-DAD and did not degrade during extraction as detected by FTIR analysis. However, extraction with a high temperature in UAE changed carotenoid isomerization from all trans to x-cis lycopene. Additionally, the anti-inflammatory properties of this ethanolic extract on THP-1 cells were investigated. As a result, the extract at the concentration of 0.25–1.00 µg/ml should be considered for its benefit in enhancing IL-1β cytokines and safe for THP 1 cell.