Miracle-dz/UniFAR-FTUs huggingface dataset:
Probiotic Properties of Exopolysaccharide-Producing Bacteria from Natto

Natto is a traditional Japanese food made from soybeans fermented with Bacillus subtilis var. natto. It is also a famous food in Thailand. Potential probiotics were screened from natto. Bacillus subtilis strain VN5 produced the most quantity of exopolysaccharide (EPS), so it was selected to study the properties of microbial EPS and probiotics. The Fourier transform infrared spectrometer or FT-IR spectroscopy confirmed the presence of carboxyl and hydroxyl groups. The patterns of FT-IR and levans are similar. The basic properties of probiotics were revealed. The 90% of VN5 strain resisted lysozyme within 30 min. VN5 survived under acidic conditions (pH 1-6), and the survival rate in 0.3%, 0.5%, and 1% bile solutions for 24 h was 100%. Unfortunately, VN5 did not inhibit the growth of Escherichia coli, Staphylococcus aureus, and Salmonella typhi. Gamma hemolysis was determined in VN5 strain. The finding on Bacillus subtilis strain (VN5) from natto paves the way to a high potential, useful new strain of probiotics.
Bloch gain in quantum cascade lasers

Laser action by a weak to vanishing population inversion is observed in mid-infrared (7 μm) quantum cascade lasers. The origin of the optical gain is the same than for the Bloch oscillator predicted in superlattices. This special gain does not only relax the threshold condition for lasing, but also underlines the major role played by coherent processes in semiconductor heterostructures, as it is based on scattering assisted optical transitions.
Study on flow past two spheres in tandem arrangement using a local mesh refinement virtual boundary method

A local mesh refinement virtual boundary method based on a uniform grid is designed to study the transition between the flow patterns of two spheres in tandem arrangement for Re=250. For a small gap (L/D=1.5), the flow field is axisymmetric. As the spacing ratio increases to 2.0, the pressure gradient induces the circumferential fluid motion and a plane‐symmetric flow is constructed through a regular bifurcation. For L/D⩾2.5, the vortices are periodically shed from the right sphere, but the planar symmetry remains. The case for L/D=3.0 is picked up to give a detail investigation for the unsteady flow. The shedding frequency of vortical structure from the upper side of the right sphere is found to be double of the frequency of the lower side. With the flow spectra of various gaps given, the underlying competitive mechanism between the two shedding frequencies is studied and a critical spacing gap is revealed. Copyright © 2005 John Wiley & Sons, Ltd.
Comparison of Periodic Flow Fields in a Radial Pump among CFD, PIV, and LDV Results

The interaction between the impeller and the diffuser is considered to have a strong influence on the unsteady flow in radial pumps. In this paper, the unsteady flow in a low specific speed radial diffuser pump has been simulated by the CFD code CFX-10. Both Particle Image Velocimetry (PIV) and Laser Doppler Velocimetry (LDV) measurements have been conducted to validate the CFD results. Both the phase-averaged velocity fields and the turbulence fields obtained from different methods are presented and compared, in order to enhance the understanding of the unsteady flow caused by the relative motion between the rotating impeller and the stationary diffuser. The comparison of the results shows that PIV and LDV give nearly the same phase-averaged velocity fields, but LDV predicts the turbulence much clearer and better than PIV. CFD underestimates the turbulence level in the whole region compared with PIV and LDV but gives the same trend.
Phytotherapy and Drugs: Can Their Interactions Increase Side Effects in Cancer Patients?

Background: The use of herbs to treat illnesses was common in all historical eras. Our aim was to describe the phytotherapeutic substances that cancer patients use most commonly, and to determine whether their use can increase side effects. Methods: This was a retrospective and descriptive study conducted among older adults actively undergoing chemotherapy, admitted at the Oncology DH Unit (COES) of the Molinette Hospital AOU Città della Salute e della Scienza in Turin (Italy). Data collection was conducted through the distribution of self-compiled and closed-ended questionnaires during chemotherapy treatment. Results: A total of 281 patients were enrolled. Evaluating retching and sage consumption was statistically significant in multivariate analysis. The only risk factor for dysgeusia was chamomile consumption. Ginger, pomegranate, and vinegar use were retained as mucositis predictors. Conclusions: Phytotherapeutic use needs more attention in order to decrease the risks of side effects, toxicity, and ineffective treatment. The conscious administration of these substances should be promoted for safe use and to provide the reported benefits.
Interconnections of Knowledge and Beliefs in Teaching Mathematics

As part of a 5-year project that examined teachers’ knowledge and beliefs about math¬ematics and teaching mathematics, interviews were conducted with preservice elementary teachers during their certification year. The transcripts of five of these sets of pretest/posttest interviews were chosen as illustrative of the significant challenges that preservice teachers continue to face as they strive to deepen their subject-specific teaching knowledge and begin to address their beliefs about teaching and learning mathematics. RésuméDans le cadre d’un projet de 5 ans visant à analyser les connaissances en mathématiques des enseignants, ainsi que leurs points de vue sur cette discipline et son enseignement, des entrevues ont été menées auprès de futurs enseignants au primaire pendant leur année de certification. La tran¬scription de cinq des séries d’entrevues (pré-test et post-test) a été choisie pour illustrer l’importance des défis que doivent continuellement affronter les enseignants en formation alors qu’ils visent à approfondir leur niveau de connaissances spécifiques à l’enseignement des mathématiques et com¬mencent à réfléchir sur leurs propres points de vue concernant l’enseignement et l’apprentissage de leur discipline.
On the outburst evolution of H1743−322: a 2008/2009 comparison

We present two observational campaigns performed with the RXTE satellite on the black hole transient H1743−322. The source was observed in outburst on two separate occasions between 2008 October–November and 2009 May–July. We have carried out timing and spectral analysis of the data set, obtaining a complete state classification of all the observations. We find that all the observations are well described by using a spectral model consisting of a disc blackbody, a power law + reflection + absorption and a Gaussian emission component. During the 2009 outburst, the system followed the canonical evolution through all the states seen in black hole transients. In the 2008 outburst only the hard states were reached. The early evolution of the spectral parameters is consistent between the two epochs, and it does not provide clues about the subsequent behaviour of the source. The variation of the flux associated to the two main spectral components (i.e. disc and power law) allows us to set a lower limit to the orbital inclination of the system of ≥43°.
Testing of Technical Fabrics under Fast Camera Control

The dynamic development of measurement and recording techniques has been changing the way one conceives material strength. In this study, two different methods of evaluating the strength of fabrics are compared. The first is the typical and commonly used technique based on the use of a testing machine. The second method uses the so-called “fast camera” to monitor the entire process of the destruction of a fabric sample and analyse the behaviour of the fabric during the experiment. Both methods provide interesting data and present a very specific way of experimentally evaluating the strength of fabrics
DYNAMICS OF A TWO-LINK FLEXIBLE SYSTEM UNDERGOING LOCKING: MATHEMATICAL MODELLING AND COMPARISON WITH EXPERIMENTS

Space structures such as the solar panels or antenna, when deployed in space, have large dimensions, low mass to size ratio, large inertias and relatively low structural rigidity. Due to space restrictions, these structures are originally in stowed configurations and are deployed into their full size in space. Typically, these systems at the end of deployment undergo locking at the joints and lose their rotational degrees of freedom at the joints. In addition, during locking vibrations are induced in these light-weight, flexible mechanisms which have to be actively or passively damped. In this paper a mathematical model with an experiment is presented for a two-link flexible system, which undergoes locking during motion. The structural flexibility is modelled by the finite element method, and the equations of motion are derived using the Lagrangian formulation. The locking at the joints is modelled by the momentum balance method, which enables one to predict the rigid body as well as the elastic motion of the system after locking. The experimental setup consists of two flexible aluminum links with a revolute joint at the end of each link, and has a locking mechanism for each joint. The links lock as a predefined angle. The links are instrumented with strain gages and the joint rotations are measured by potentiometers. The sensor readings are acquired and stored on a PC based data acquisition system. The simulation results such as the locking time, response of each joint and the strain at the base of each link match very well with the experimental results. Thus, the momentum balance method is capable of predicting fairly accurately the dynamics of a flexible system which undergo locking during motion.
Monocyte/HDL Cholesterol Ratios as a New Inflammatory Marker in Patients with Schizophrenia

Purpose: Monocyte/HDL cholesterol ratio (MHR) is a novel inflammatory marker that is used as a prognostic factor for cardiovascular diseases and has been studied in many diseases. The aim of this study was to investigate the role of inflammatory factors in schizophrenia patients by examining MHR levels and to compare schizophrenia patients and healthy controls in terms of cardiovascular disease risk. Method: A total of 135 participants between the ages of 18–65, 85 diagnosed with schizophrenia, and 50 healthy individuals in the control group were included in this cross-sectional study. Venous blood samples were taken from the participants and CBC parameters and lipid profiles were analyzed. The sociodemographic and clinical data form and positive and negative symptoms scale (PANSS) were administered to all participants. Results: Although monocyte levels were significantly higher in the patient group, HDL-C levels were lower at significant levels. MHR was found to be higher in the patient group compared to the control group at significant levels. When compared to the control group, total cholesterol, triglyceride, WBC, neutrophil, basophil, and platelet levels were higher in the patient group at significant levels, and RBC, hemoglobin, and hematocrit levels were significantly lower. Conclusion: The elevated MHR in patients with schizophrenia may contribute to our understanding that inflammation plays important roles in the pathophysiology of schizophrenia. Additionally, knowing the levels of MHR and considering the recommendations, such as diet and exercise, in the treatment approaches made us think that it might be beneficial in protecting schizophrenia patients against cardiovascular diseases and early death.
Progress towards heterodyne-type single-mode fiber communication systems

The unique performances attached to the heterodyne (or coherent) optical detection process can be fully exploited with single-mode fiber transmission. Strong improvement over direct detection is expected in terms of bit error rate (BER) or in terms of repeater spacing, especially for 1.6 μm operation. The requirements of such a system are reviewed and interpreted in terms of individual components design. The emission frequency stability of laser diodes, the ability of single-mode fiber cables to maintain polarization, and the availability of direct light amplifiers are found to be the most critical points, and recent theoretical and experimental results are reported. It is concluded from these very promising results that a heterodyne-type communication system using single-mode fibers at 1.6 μm may offer repeater spacings of over 200 km in the near future.
The simplified self-consistent probabilities method for percolation and its application to interdependent networks

Interdependent networks in areas ranging from infrastructure to economics are ubiquitous in our society, and the study of their cascading behaviors using percolation theory has attracted much attention in recent years. To analyze the percolation phenomena of these systems, different mathematical frameworks have been proposed, including generating functions and eigenvalues, and others. These different frameworks approach phase transition behaviors from different angles and have been very successful in shaping the different quantities of interest, including critical threshold, size of the giant component, order of phase transition, and the dynamics of cascading. These methods also vary in their mathematical complexity in dealing with interdependent networks that have additional complexity in terms of the correlation among different layers of networks or links. In this work, we review a particular approach of simple, self-consistent probability equations, and we illustrate that this approach can greatly simplify the mathematical analysis for systems ranging from single-layer network to various different interdependent networks. We give an overview of the detailed framework to study the nature of the critical phase transition, the value of the critical threshold, and the size of the giant component for these different systems.
A Novel Liver X Receptor Inverse Agonist Impairs Cholesterol and Phospholipid Metabolism and Induces Apoptosis and Necroptosis in Pancreatic Ductal Adenocarcinoma Cells

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease with a high mortality rate and few effective treatments. A growing area of cancer therapeutics seeks to exploit the metabolic dysregulation of cancer cells, such as glucose, amino acid, and fatty acid metabolism, to selectively target malignant cells. As ligand-dependent transcription factors and critical regulators of metabolism, liver X receptors (LXRs) are amenable to small-molecule targeting for such purposes. We have profiled the transcriptomic, metabolomic, and cytotoxic effects of a newly discovered small-molecule LXR modulator, GAC0003A4 (3A4), in PDAC cell lines. On the transcriptomic level, marked changes in gene expression were observed, including downregulation of LXR target genes and pathways. Gene set enrichment analysis determined downregulation of several metabolic pathways, such as fatty acid and cholesterol metabolism, while upregulated pathways involved TNFα/NF-κB and other stress-induced processes. Metabolomic analyses revealed altered metabolites in several pathways, the most enriched categories being lipids and amino acid metabolites, while phospholipids and sphingolipids, including ceramides, were also found to be significantly altered. Insights from transcriptomic and metabolomic studies helped guide the determination of alterations in cholesterol and ceramides as integral to the antiproliferative mechanisms of 3A4. Additionally, a concurrent programmed cell death mechanism involving apoptosis and necroptosis was shown to be activated. These studies provide novel insights into the effects of LXR modulation on gene expression, metabolism, and cell death induction in PDAC cells. The metabolic and cytotoxic effects of LXR modulation on the PDAC cell lines used in this study could also aid in the design and application of drugs to target other refractory cancers.
Two-dimensional control of field-driven magnetic bubble movement using Dzyaloshinskii–Moriya interactions

The field-induced asymmetric growth of magnetic bubble domains in Pt/Co/Pt out-of-plane magnetized films with Dzyaloshinskii–Moriya interactions (DMI) is used to control the lateral displacement of bubbles. We demonstrate experimentally that we can laterally translate bubbles away from their nucleation site by applying a series of alternating 3-dimensional field pulses with a controlled relative sign between the out-of-plane and in-plane components. Using magneto optical Kerr effect imaging, the domain wall velocity as a function of applied field strength was measured from which the magnitude of the DMI field was estimated.
Low Temperature In Situ Synthesis of ZnO Nanoparticles from Electric Arc Furnace Dust (EAFD) Waste to Impart Antibacterial Properties on Natural Dye-Colored Batik Fabrics

Natural polymer (cellulose)-based fabric was colored using an environmentally friendly natural dye extracted from Jalawe (Terminalia bellirica) in the preparation of Batik fabric, a cultural heritage of Indonesia that is recognized by United Nations Educational, Scientific and Cultural Organization (UNESCO). Despite the significant favorable properties in terms of functions, environmental, and cultural aspects, the combination between natural polymer-based fabric and natural dyes makes the Batik fabric an ideal medium for bacterial growth, leading to lower product quality. In the quest for a sustainable, environmentally friendly, rich-in-culture, yet durable textile, this study aimed at the functionalization of natural dye (ND)-colored Batik fabric with antibacterial ZnO nanoparticles (ZnO NPs) synthesized from Electric Arc Furnace Dust (EAFD) waste. An in situ immobilization process with a Chemical Bath Deposition (CBD) method was explored at a pH range from 6 to 11 at 50 °C. Characterization methods include XRD, XRF, FESEM, EDX, FT-IR, tensile strength measurement, agar diffusion testing, and a CIE L*a*b* scale measurement. The XRD and XRF results showed that pure (>98%) ZnO NPs were formed at pH 11 of the CBD process. FESEM results demonstrated that the pure ZnO NPs either precipitated at the CBD reactor or were immobilized on the cellulose fabric, exhibiting distinct morphology compared to the non-pure ZnO NPs. EDX elemental analysis before and after washing demonstrated the durability of the ZnO NPs attachment, in which 84% of the ZnO NPs remained on the fabric after two washing cycles (equal to 10 cycles of home laundering). The FT-IR spectra provided information on the chemical functional groups, demonstrating the success of the ZnO NPs immobilization on the cellulose fabric through Van der Waals or coordination bonding. Moreover, the in situ immobilization of ZnO NPs enhanced the Batik fabric’s tensile strength but reduced its elongation. ZnO NP-functionalized Batik fabric that was treated at pH 10 and pH 11 showed antibacterial activity against Staphylococcus aureus. The CIE L*a*b* scale results showed that the immobilization process affects the color quality of the ND-colored Batik fabric. However, based on organoleptic observations, the color of the Batik fabric that was treated at pH 11 is still acceptable for Jalawe ND-colored Batik fabric.
β-Cryptoxanthin Attenuates Cigarette-Smoke-Induced Lung Lesions in the Absence of Carotenoid Cleavage Enzymes (BCO1/BCO2) in Mice

High dietary intake of β-cryptoxanthin (BCX, an oxygenated provitamin A carotenoid) is associated with a lower risk of lung disease in smokers. BCX can be cleaved by β-carotene-15,15′-oxygenase (BCO1) and β-carotene-9′,10′-oxygenase (BCO2) to produce retinol and apo-10′-carotenoids. We investigated whether BCX has protective effects against cigarette smoke (CS)-induced lung injury, dependent or independent of BCO1/BCO2 and their metabolites. Both BCO1−/−/BCO2−/− double knockout mice (DKO) and wild type (WT) littermates were supplemented with BCX 14 days and then exposed to CS for an additional 14 days. CS exposure significantly induced macrophage and neutrophil infiltration in the lung tissues of mice, regardless of genotypes, compared to the non-exposed littermates. BCX treatment significantly inhibited CS-induced inflammatory cell infiltration, hyperplasia in the bronchial epithelium, and enlarged alveolar airspaces in both WT and DKO mice, regardless of sex. The protective effects of BCX were associated with lower expression of IL-6, TNF-α, and matrix metalloproteinases-2 and -9. BCX treatment led to a significant increase in hepatic BCX levels in DKO mice, but not in WT mice, which had significant increase in hepatic retinol concentration. No apo-10′-carotenoids were detected in any of the groups. In vitro BCX, at comparable doses of 3-OH-β-apo-10′-carotenal, was effective at inhibiting the lipopolysaccharide-induced inflammatory response in a human bronchial epithelial cell line. These data indicate that BCX can serve as an effective protective agent against CS-induced lung lesions in the absence of carotenoid cleavage enzymes.
The Association between Physical Environment and Externalising Problems in Typically Developing and Neurodiverse Children and Young People: A Narrative Review

The physical environment is of critical importance to child development. Understanding how exposure to physical environmental domains such as greenspace, urbanicity, air pollution or noise affects aggressive behaviours in typical and neurodiverse children is of particular importance given the significant long-term impact of those problems. In this narrative review, we investigated the evidence for domains of the physical environment that may ameliorate or contribute to the display of aggressive behaviours. We have considered a broad range of study designs that include typically developing and neurodiverse children and young people aged 0–18 years. We used the GRADE system to appraise the evidence. Searches were performed in eight databases in July 2020 and updated in June 2022. Additional articles were further identified by hand-searching reference lists of included papers. The protocol for the review was preregistered with PROSPERO. Results: We retrieved 7174 studies of which 67 are included in this review. The studies reported on green space, environmental noise and music, air pollution, meteorological effects, spatial density, urban or rural setting, and interior home elements (e.g., damp/sensory aspects/colour). They all used well validated parent and child reported measures of aggressive behaviour. Most of the studies were rated as having low or unclear risk of bias. As expected, noise, air pollution, urbanicity, spatial density, colour and humidity appeared to increase the display of aggressive behaviours. There was a dearth of studies on the role of the physical environment in neurodiverse children. The studies were heterogeneous and measured a range of aggressive behaviours from symptoms to full syndromes. Greenspace exposure was the most common domain studied but certainty of evidence for the association between environmental exposures and aggression problems in the child or young person was low across all domains. We found a large knowledge gap in the literature concerning neurodiverse children, which suggests that future studies should focus on these children, who are also more likely to experience adverse early life experiences including living in more deprived environments as well as being highly vulnerable to the onset of mental ill health. Such research should also aim to dis-aggregate the underlying aetiological mechanisms for environmental influences on aggression, the results of which may point to pathways for public health interventions and policy development to address inequities that can be relevant to ill health in neurodiverse young people.