Miracle-dz/UniFAR-FTUs huggingface dataset:
Anti-Inflammatory Effect of Meriania hexamera Sprague by Targeting Syk Kinase in NF-κB Signaling

Inflammation is a protective mechanism against harmful stimuli. There are two types of inflammation, acute and chronic, and severe diseases such as cardiovascular disease and cancer can be caused by chronic inflammation. Therefore, this research was conducted to discover new anti-inflammatory drugs. Meriania hexamera Sprague is a common herb in the Amazon region in South America. It is used as a traditional medical herb by natives, but no studies to date have investigated its anti-inflammatory activity. Using lipopolysaccharide (LPS), pam3CSK4 (Pam3), and poly(I:C), we studied the M. hexamera Sprague–Methanol Extract’s (Mh-ME) in vitro anti-inflammatory functions. Using RAW264.7 cells, we detected the released nitric oxide (NO) and mRNA expression extent of inducible nitric oxide synthase (iNOS) with pro-inflammatory proteins like tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), and iterleukin-1 beta (IL-1β). It was found that Mh-ME suppressed the inflammatory activities in a dose-dependent manner. In the luciferase assay, the nuclear factor kappa light chain enhancer of the activated B cells (NF-κB) pathway was inhibited by Mh-ME. Mh-ME especially acted as an inhibitor of Syk kinase according to the results from CETSA. We also confirmed that Mh-ME mitigates acute gastritis derived from HCl/EtOH in ICR mice, ameliorating the expression of IL-1β and tumor necrosis factor-alpha (TNF-α). In conclusion, Mh-ME is an herb with anti-inflammatory effects that targets Syk in the NF-κB pathway, suggesting that Mh-ME could be used as an anti-inflammatory herbal medicine.
A Review on Hardfacing, Process Variables, Challenges, and Future Works

Hardfacing is an efficient and economical surfacing technique widely used by heavy industries to remediate worn components in service or to enhance the component’s wear characteristics components prior to use. Efficient hardfacing for any targeted application requires precise consideration and understanding of the deposition process, consumables, and substrates. It is also essential to understand the process variables and issues that can occur during the deposition processes, such as dilution and defects in the deposit, including residual stress-induced cracking. Significant research has been published over many years on several aspects of hardfacing, primarily focusing on abrasive wear, corrosion, and impact characterisation using different welding methods and alloy compositions. This paper primarily focuses on reviewing the prior hardfacing literature to systematically summarise the considerations and selection criteria for hardfacing processes and materials. It also presents a discussion on key process variables, such as welding parameters and number of surfacing layers, highlighting their influences during the hardfacing deposition procedure. This paper further discusses issues and challenges in hardfacing practices, such as dilution and cracking. One significant issue investigated is the thermal damage to high-strength steel substrates, with the measurement and characterisation of the damage being key elements. The focus of this investigation is to discuss the optimisation of hardfacing high-strength steel substrates and to communicate potential research areas and prospective applications in the hardfacing industry.
Trans-scaphoid Lunate Dislocation Rare Injury: A Case Report

Lunate dislocations are complex and uncommon wrist injuries, often resulting from high-energy trauma like road traffic accidents, falls, and industrial mishaps. Timely diagnosis and appropriate surgical management are critical to achieving favorable outcomes and minimizing long-term disability. Here, we present a case of a 22-year-old male who sustained a trans-scaphoid lunate fracture dislocation due to a motorcycle accident. Prompt wrist x-ray evaluation and subsequent surgical interventions led to the successful restoration of wrist function and stability. This case report highlights the importance of early recognition and discusses the accurate diagnosis and timely management of lunate fracture dislocations to avoid long-term complications and disability.
Effect of Time on the Properties of Bio-Nanocomposite Films Based on Chitosan with Bio-Based Plasticizer Reinforced with Nanofiber Cellulose

The deterioration of the performance of polysaccharide-based films over time, particularly their hydrophilicity and mechanical properties, is one of the main problems limiting their applications in the packaging industry. In the present study, we proposed to improve the performance of chitosan-based films through the use of: (1) nanocellulose as an additive to reduce their hydrophilic nature; (2) bio-based plasticizer to improve their mechanical properties; and (3) chestnut extract as an antimicrobial agent. To evaluate their stability over time, the properties of as-formed films (mechanical, hydrophilic, barrier and antibacterial) were studied immediately after preparation and after 7, 14 and 30 days. In addition, the morphological properties of the films were characterized by scanning electron microscopy, their structure by FTIR, their transparency by UV-Vis and their thermal properties by TGA. The films showed a hydrophobic character (contact angle above 100°), barrier properties to oxygen and carbon dioxide and strong antibacterial activity against Gram-negative (E. coli) and Gram-positive (S. aureus) bacteria. Moreover, the use of nanofillers did not deteriorate the elongation at breaks or the thermal properties of the films, but their addition reduced the transparency. In addition, the results showed that the greatest change in film properties occurred within the first 7 days after sample preparation, after which the properties were found to stabilize.
A progressive dilemma? Investigating cross-country variations in family-immigration policies through the lens of welfare-state regimes

ABSTRACT The notion of a ‘progressive dilemma’, according to which there is an intrinsic tension between comprehensive welfare states and large-scale immigration, has figured prominently in scholarly as well as political debates over the last decade. As one of the main categories of entry in most affluent democracies, family immigration stands out as a particularly interesting test case in this context. Building on this notion of a progressive dilemma, as well as on other theorizing on the welfare-migration nexus, this study examines whether the restrictive effects of certain risk factors on family-immigration policies, such as growing immigration and rising unemployment, have been conditioned by the type of welfare regime. The empirical analysis herein finds that increasing immigration and higher unemployment have triggered policy restrictions in Basic Security welfare states, but that the influence of these factors on policy changes is less clear in State Corporatist and Universal welfare states. Contrary to what the idea of the progressive dilemma would lead us to expect, Basic Security welfare states with weaker universal and redistributive features have been more likely to sharpen restrictions on the admission of family migrants when under pressure from increasing immigration and rising unemployment.
Serodiagnosis of Abdominal Abscess Caused by Burkholderia pseudomallei: Case Report and Literature Review

Abstract Burkholderia pseudomallei, the causative agent of melioidosis can be responsible for a wide spectrum of clinical manifestations and heterogeneous prognoses, with a high mortality in the acute onset. We report a case of a deep abdominal abscess with sepsis secondary to melioidosis in a young farmer from a non-high-risk population. Emergency medical treatment was administered according to the detection of serum antibodies against Hcp1, the results of which provided etiological evidence of B. pseudomallei infection for the timely and properly antimicrobial therapy in the absence of direct evidence of melioidosis. To our knowledge, this is the first reported case of serodiagnosis of acute exacerbation of melioidosis in China.
Race and ethnicity moderate the associations between lifetime psilocybin use and crime arrests

Introduction Psilocybin use has been linked to lowered odds of crime-related outcomes across a host of observational studies. No studies have investigated how these associations may differ among those of different races and ethnicities. Methods Using a nationally-representative sample of 734,061 adults from the National Survey on Drug Use and Health (2002–2020), we investigated whether race and ethnicity moderate the associations between lifetime psilocybin use and four measures of crime arrests (property crime, assault, serious violence, and miscellaneous crimes). Results First, we replicated prior findings and demonstrated that psilocybin confers lowered odds of crime arrests for all four outcomes in question. Second, we demonstrated that race and ethnicity moderate the associations between lifetime psilocybin use and crime arrests for three of our four outcomes. Third, we examined the associations between psilocybin and crime arrests across different races and ethnicities (White, Black, Indigenous, Asian, Multiracial, and Hispanic participants). Psilocybin conferred lowered odds of at least one crime arrest outcome for all racial and ethnic groups except for Black and Hispanic participants. Discussion Future investigations should take an intersectional approach to studying the interrelationship of sociodemographic factors, psychedelic use, and crime, examine the structural factors (i.e., systemic racism) that may underlie these results, and investigate whether psychedelics can alleviate mental health disorders that contribute to cycles of recriminalization for communities of color.
Predictive Value of Hypomineralization of Second Primary Molars for Molar Incisor Hypomineralization and Other Relationships between Both Developmental Defects of Dental Enamel

Molar incisor hypomineralization (MIH) and hypomineralized second primary molars (HSPM) are dental enamel developmental defects with significant prevalence and psychophysical impact, posing a public health concern. We examined the relationship between HSPM and MIH in 426 children aged 7 to 10 years (213 with MIH, 213 without MIH). The frequency of HSPM was higher in children with MIH (37.1% vs. 11.3%, p < 0.001). However, there was no correlation between MIH severity and presence of HSPM (p = 0.296). In patients with both defects (n = 79), 90% of severe MIH cases were associated with severe HSPM, while 87.8% of mild MIH cases were associated with mild HSPM (p < 0.001). The involvement of permanent incisors by MIH was not influenced by the presence of HSPM or HSPM severity. HSPM exhibited a positive predictive value of 76.7, negative predictive value of 58.8, sensitivity of 37.1% (95% CI = 30.6–43.6%), and specificity of 88.7% (95% CI = 84.5–93%). The odds ratio for MIH based on HSPM was 4.64 (95% CI). HSPM may serve as a predictor of MIH, but its absence does not rule out the occurrence of MIH. The results highlight the need for surveillance programs in children presenting with HSPM to facilitate early diagnosis and preventive measures for MIH-related complications.
Cannabinoid receptor type 1 in the aging gut regulates the mucosal permeability via miR-191-5p

Background Aging is associated with a broad loss of function throughout the body, and gastrointestinal (GI) dysfunction can occur with aging. The endocannabinoid (eCB) system plays a pivotal role in various GI diseases, and alterations in the eCB system have been observed during brain and skin aging. Therefore, we investigated the putative role of the eCB system in aging-related changes in the intestine. Methods The expression of cannabinoid receptor type 1 (CB1) was investigated in rat intestinal tissues using quantitative real-time PCR. Cellular senescence was induced by hydrogen peroxide (H2O2) and hydroxyurea (HU) in rat and human intestinal epithelial cells. Cellular permeability was evaluated by transepithelial electrical resistance (TEER) measurement. Results and Discussion The expression of CB1 was decreased in the small intestine of aged rats compared to that of young rats. Senescent cells showed reduced TEER values and decreased expression of ZO-1, indicating increased intestinal permeability, which is tightly regulated by the CB1 signaling. In silico miRNA analysis suggested that ZO-1 was a direct target gene of miR-191-5p. Increased expression of miR-191-5p by HU was restored by CB1 agonist ACEA co-treatment. Moreover, NF-κB p65 activation was associated with CB1-related miR-191-5p signaling. In conclusion, aging-induced CB1 reduction leads to increased intestinal permeability and decreased ZO-1 expression via upregulation of miR-191-5p and NF-κB p65 activation. Taken together, these results suggest that CB1 signaling may be a useful strategy to reduce intestinal permeability in aging-related and other inflammatory conditions in the gut.
The core role of macrophages in hepatocellular carcinoma: the definition of molecular subtypes and the prognostic risk system

Background: In patients with hepatocellular carcinoma (HCC), the tumor microenvironment (TME) is resistant to immunotherapy because of its specificity. It is meaningful to explore the role of macrophage, which is one of the most abundant immune cells in the TME, in cellular communication and its effect on the prognosis and immunotherapy of HCC. Methods: Dimensionality reduction and clustering of the single-cell RNA-seq data from the GSE149614 dataset were carried out to identify the cellular composition of HCC. CellChat was used to analyze the communication between different cells. The specifically highly expressed genes of macrophages were extracted for univariate Cox regression analysis to obtain prognostic genes for HCC cluster analysis, and the risk system of macrophage-specifically highly expressed genes was developed by random forest analysis and multivariate Cox regression analysis. Prognosis, TME infiltration, potential responses to immunotherapy, and antineoplastic drugs were compared among molecular subtypes and between risk groups. Results: We found that HCC included nine identifiable cell types, of which macrophages had the highest communication intensity with each of the other eight cell types. Of the 179 specifically highly expressed genes of macrophage, 56 were significantly correlated with the prognosis of HCC, which classified HCC into three subtypes, which were reproducible and produced different survival outcomes, TME infiltration, and immunotherapy responses among the subtypes. In the integration of four macrophage-specifically highly expressed genes for the development of a risk system, the risk score was significantly involved in higher immune cell infiltration, poor prognosis, immunotherapy response rate, and sensitivity of six drugs. Conclusion: In this study, through single-cell RNA-seq data, we identified nine cell types, among which macrophage had the highest communication intensity with the rest of the cell types. Based on specifically highly expressed genes of macrophage, we successfully divided HCC patients into three clusters with distinct prognosis, TME, and therapeutic response. Additionally, a risk system was constructed, which provided a potential reference index for the prognostic target and preclinical individualized treatment of HCC.
Troy III-V: new radiocarbon dates confirm a gap in Blegen՚s sequence

­ To investigate the dating of Troy III­V, and in particular to test whether in Blegen's Troy se­ quence a gap exists between Troy III and Troy IV, 26 bone samples covering Troy III to VIa from the Uni­ versity of Cincinnati excavations were submitted for 14 C­AMS analysis. Excluding outliers, they yield dates that are consistent with a chronological scheme which includes a 110±20 year gap after Troy III, with Troy IV beginning 2060±10 cal BC. The hypothesis of a Proto­IV period which might bridge the gap, featuring deposits known only from the more recent excavations, can therefore be entertained.
On the evaluation of the phase relation between temperature and wind tides based on ground-based measurements and reanalysis data in the middle atmosphere

Abstract. The variability in the middle atmosphere is driven by a variety of waves covering different spatial and temporal scales. We diagnose the variability in the thermal tides due to changes in the background wind by an adaptive spectral filter, which takes the intermittency of tides into account. We apply this diagnostic to temperature observations from daylight-capable lidar at midlatitudes (54∘ N, 12∘ E) as well as to reanalysis data of horizontal winds from Modern-Era Retrospective analysis for Research and Applications, Version 2 (MERRA-2). These reanalysis data provide additional wind information in the altitude range between 30 and 70 km at the location of the lidar as well as on a global scale. Using the global data gives information on the tidal modes seen at one location. A comparison of the temperature and wind information affirms whether there is a fixed phase relation of the tidal waves in the temperature and the wind data. We found that in general the local tidal signatures are dominated by migrating tidal modes, and the signature is weaker in temperatures than in winds. While the meridional wind tide leads the zonal wind tide by 90∘, the phase relation between the temperature and the wind tide is more complex. At certain altitudes the temperature tide follows the zonal wind tide. This knowledge helps in improving the interpretation of the seasonal variation in tides from different observables, especially when only data from single locations are used. The findings provide additional information about the phase stability of tidal waves, and the results clearly show the importance of a measurement acquisition on a routine basis with high temporal and spatial resolution.
Morphophysiology and gas exchange of pomegranate under salt stress and foliar application of nitrogen

ABSTRACT Salinity is one of the abiotic stresses that affect gas exchange and growth of pomegranate. In this context, the application of nitrogen fertilizer through the leaves can minimize these effects. Thus, the objective of present study was to evaluate the effect of foliar nitrogen fertilization on pomegranate seedlings irrigated with brackish water. The design used was randomized blocks, in an incomplete factorial scheme (Central Composite Design) with five electrical conductivities of irrigation water - ECw (0.50, 1.15, 2.75, 4.35, and 5.00 dS m-1) and five doses of foliar nitrogen fertilization - FNF (0, 0.33, 1.15, 1.97, and 2.30 g L-1), with four replicates and two plants per experimental plot. Plant height, number of leaves, stem diameter, and gas exchange (stomatal conductance, net photosynthesis, intercellular CO2 concentration, transpiration rate, instantaneous carboxylation efficiency, instantaneous water use efficiency, and intrinsic water use efficiency) were evaluated at 60 days after the beginning of irrigation with saline water. Salinity of irrigation water negatively affects the gas exchange of pomegranate seedlings. Foliar nitrogen fertilization up to 1.31 g L-1 improves plant height and number of leaves in pomegranate seedlings under salt stress. Foliar nitrogen fertilization up to 1.59 g L-1 increases the net photosynthesis of pomegranate seedlings.
Investigating the association of physical and psychological problems with the levels of interleukin-1 and -6 in COVID-19 patients

Introduction The COVID-19 virus spreads at a high rate, exerting many physical, mental and psychological effects on patients. Patients with COVID-19 have been reported to have high levels of interleukin 1 and interleukin 6. Therefore, this study was conducted to determine the association of physical, mental, and psychological problems with the levels of interleukin-1 and -6 in COVID-19 patients. Methodology This is cross-sectional descriptive-analytical research on 121 COVID-19 patients selected using simple random sampling method. The patients were hospitalized in university hospitals affiliated to Ahvaz Jundishapur University of Medical Sciences and Amir al-Momenin Hospital. Data collection tools included the depression anxiety stress scale (DASS), a demographic questionnaire, and a checklist of physical problems. Blood sampling was also done to perform an ELISA test and measure the level of interleukin-1 and -6. Data were analyzed based on independent t-tests, chi-square, regression, and Pearson’s correlation coefficient, using SPSS ver. 22. Results The average age of the 121 patients participating in this study was 53.31 ± 14.09. A direct and statistically significant correlation was observed between body temperature on the first day and interleukin 1 level. A statistically significant negative correlation was observed between blood oxygen saturation level and interleukin-1 and -6 on the first, third and fifth days. Shortness of breath and coughing had a statistically significant correlation with the level of interleukin 1 on the third and fifth days. A direct and statistically significant correlation was observed between body temperature on the first, third and fifth days and interleukin 6 level. Coughing on the third and fifth days had a statistically significant relationship with interleukin 6 level. No direct and non-significant statistical correlation was found between depression and stress and the serum level of interleukin 1, but a significant correlation was observed between anxiety and serum level of interleukin 1. Finally, the results showed that depression, anxiety and stress had a direct and statistically significant correlation with the serum level of interleukin 6. Conclusion Given the relationship between interleukin-1 and -6 and most physical and psychological problems, level of the inflammatory biomarkers interleukin-1 and -6 can be used to estimate the severity of physical and psychological symptoms in COVID-19 patients.
Spatial analysis of tuberculosis and its relationship with socioeconomic factors in Paraíba: An ecological study

Objective: To analyze the spatial distribution of tuberculosis and its association with socioeconomic factors. Method : A mixed-methods ecological study with spatial analysis of tuberculosis cases in the state of Paraíba, reported from 2015 to 2018. Results: A total of 6,082 cases were reported, with a mean incidence of 37.4/100,000 inhabitants. No municipality was classified as having “very low” development, although statistical significance exists between the incidence rates and the socioenvironmental factors. Conclusion: The Moran Index pointed out a positive autocorrelation between areas with high incidence values. The Moran Map reveals clusters that indicate a concentration of the infection between Zona da Mata and Agreste Paraibano , the largest of which comprises 19 municipalities