Miracle-dz/UniFAR-FTUs huggingface dataset:
Detection of Trichomonas Vaginalis Infection in Chronic Prostatitis/Chronic Pelvic Pain Syndrome Patients by Rapid Immunochromatographic Test

Abstract This study aims to evaluate associations between the immunochromatographic rapid test technique and Trichomonas vaginalis (TV) infection in patients with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) in Taiwan. All patients received post-prostate massage urine (VB3) Trichomonas rapid tests. The demographic characteristics and urogenital symptoms of CP/CPPS were recorded. Routine urinalysis of VB3 was also performed, and laboratory examination results of semen were recorded if available. A total of 29 patients with TV infection and 109 without TV infection were enrolled, which reflected that the prevalence in patients with TV infection was approximately 21%. Patients with TV infection displayed a significantly higher frequency of suprapubic/lower abdominal pain (p = 0.034), semen leukocyte > 5/high-power field (HPF) (p = 0.020), and an inflammatory type (category IIIA) (p = 0.005) than patients without TV infection. A higher prevalence of TV infection was found in patients with category IIIA (47.37%). No significant difference was found in the symptom duration and other clinical symptoms. In conclusion, the high prevalence of TV infection was revealed in CP/CPPS patients using the VB3 rapid Trichomonas test, especially in CP/CPPS patients with category IIIA. Thus, rapid TV testing might be vital for CP/CPPS patients in the hospital.
Analyzing Environmental Data

Preface. 1 Linear regression. 1.1 Simple linear regression. 1.2 Multiple linear regression. 1.3 Qualitative predictors: ANOVA and ANCOVA models. 1.4 Random--effects models. 1.5 Polynomial regression. Exercises. 2 Nonlinear regression. 2.1 Estimation and testing. 2.2 Piecewise regression models. 2.3 Exponential regression models. 2.4 Growth curves. 2.5 Rational polynomials. 2.6 Multiple nonlinear regression. Exercises. 3 Generalized linear models. 3.1 Generalizing the classical linear model. 3.2 Theory of generalized linear models. 3.3 Specific forms of generalized linear models. Exercises. 4 Quantitative risk assessment with stimulus--response data. 4.1 Potency estimation for stimulus--response data. 4.2 Risk estimation. 4.3 Benchmark analysis. 4.4 Uncertainty analysis. 4.5 Sensitivity analysis. 4.6 Additional topics. Exercises. 5 Temporal data and autoregressive modeling. 5.1 Time series. 5.2 Harmonic regression. 5.3 Autocorrelation. 5.4 Autocorrelated regression models. 5.5 Simple trend and intervention analysis. 5.6 Growth curves revisited. Exercises. 6 Spatially correlated data. 6.1 Spatial correlation. 6.2 Spatial point patterns and complete spatial randomness. 6.3 Spatial measurement. 6.4 Spatial prediction. Exercises. 7 Combining environmental information. 7.1 Combining P--values. 7.2 Effect size estimation. 7.3 Meta--analysis. 7.4 Historical control information. Exercises. 8 Fundamentals of environmental sampling. 8.1 Sampling populations -- simple random sampling. 8.2 Designs to extend simple random sampling. 8.3 Specialized techniques for environmental sampling. Exercises. A Review of probability and statistical inference. A.1 Probability functions. A.2 Families of distributions. A.3 Random sampling. A.4 Parameter estimation. A.5 Statistical inference. A.6 The delta method. B Tables. References. Author index. Subject index.
Joint association of food nutritional profile by Nutri-Score front-of-pack label and ultra-processed food intake with mortality: Moli-sani prospective cohort study

Abstract Objective To jointly analyse two food dimensions, the Food Standards Agency Nutrient Profiling System (FSAm-NPS), used to derive the Nutri-Score front-of-pack label, and the NOVA classification in relation to mortality. Design Prospective cohort study. Setting Moli-sani Study, Italy 2005-10. Participants 22 895 participants (mean age 55 (SD 12) years; 48% men). Main outcomes measures Associations between dietary exposures and mortality risk, assessed using multivariable cause specific Cox proportional hazard models controlled for known risk factors. Results A total of 2205 deaths occurred during 272 960 person years of follow-up. In the highest quarter of the FSAm-NPS index compared with the lowest quarter, multivariable adjusted hazard ratios for all cause and cardiovascular mortality were 1.19 (95% confidence interval 1.04 to 1.35; absolute risk difference 4.3%, 95% confidence interval 1.4% to 7.2%) and 1.32 (1.06 to 1.64; 2.6%, 0.3% to 4.9%), respectively. The hazard ratios were 1.19 (1.05 to 1.36; absolute risk difference 9.7%, 5.0% to 14.3%) and 1.27 (1.02 to 1.58; 5.0%, 1.2% to 8.8%), respectively, for all cause and cardiovascular mortality when the two extreme categories of ultra-processed food intake were compared. When these two indices were analysed jointly, the magnitude of the association of the FSAm-NPS dietary index with all cause and cardiovascular mortality was attenuated by 22.3% and 15.4%, respectively, whereas mortality risks associated with high ultra-processed food intake were not altered. Conclusions Adults with the lowest quality diet, as measured using the FSAm-NPS dietary index (underpinning the Nutri-Score), and the highest ultra-processed food consumption (NOVA classification) were at the highest risk for all cause and cardiovascular mortality. A significant proportion of the higher mortality risk associated with an elevated intake of nutrient poor foods was explained by a high degree of food processing. In contrast, the relation between a high ultra-processed food intake and mortality was not explained by the poor quality of these foods.
Payment Measures, Interest, and Discounting

Abstract Streams of payments are represented as measures on the real line. A wide class of consistent rules for evaluation of payment streams are determined from a set of basic axioms. Additional regularity requirements lead to valuating any payment stream by the integral of a positive discount function with respect to the payment measure. Inter-relationships between generalized annuities and lump sum payments are obtained by the general rule of integration by parts. By placing probability distributions on the payment measures and possibly on the discount function, a wide class of actuarial and related problems are put on the same footing.
Molecular Electromagnetism: A Computational Chemistry Approach

1. Introduction I QUANTUM MECHANICAL FUNDAMENTALS 2. The Schrodinger Equation in the Presence of Fields 3. Perturbation Theory II DEFINITION OF PROPERTIES 4. Electric Properties 5. Magnetic Properties 6. Properties Related to Nuclear Motion 7. Frequency-Dependent and Spectral Properties 8. Vibrational Contributions to Molecular Properties III COMPUTATIONAL METHODS 9. Short Review of Electronic Structure Methods 10. Approximations to Exact Perturbation and Response Theory Expressions 11. Perturbation and Response Theory with Approximate Wavefunctions 12. Derivative Methods 13. Examples of Calculations and Practical Issues IV APPENDICES A. Operators B. Definitions of Properties C. Perturbation Theory Expressions for Properties
When teaching breaks down: Teachers rationally select what information to share, but misrepresent learners' hypothesis spaces

Although we possess intuitions about pedagogy from early in life, adults commonly fail to teach effectively in real-world situations. Why might adults struggle in more complex teaching tasks? Here we develop a simple teaching task where adults fail to teach naïve learners, despite reporting high confidence that they taught effectively. Using a formal model of a rational teacher, we analyze the sources of our adult teachers’ failures. Our model-based analyses reveal that teachers successfully provided high-quality examples, but failed to address hypotheses that naïve learners find plausible. We validate these results in a second experiment, where we find that constraining learners’ hypothesis space increases their performance in the task. Our findings help bridge the gap between children’s teaching proficiency in constrained tasks, and adults’ teaching failures in more naturalistic tasks.
Genomic Surveillance: Circulating lineages and genomic variation of SARS-CoV-2 in early pandemic in Circulating lineages and genomic variation of SARS-CoV-2 in early in

In the Northeast of Brazil, Ceará was the second state most impacted by COVID-19 in number of cases and death rate. Despite that, the early dynamics of the pandemic in Ceará was not yet well understood due the low genomic surveillance of SARS-CoV-2 in 2020. In this study, we analyze the circulating lineages and the genomic variation of the virus in Ceará state. Thirty-four genomes were sequenced and combined with sequences available in GISAID database from March 2020 to June 2021 to compose the study dataset. The most prevalent lineages detected were B.1. 1.33, in 2020, and P.1, in 2021. Other lineages were found, such as P.2, sublineages of P.1, B.1, B.1. 1, B.1. 1.28 and B.1. 212. Analyzing the mutations, a total of 202 single-nucleotide polymorphisms (SNPs) were identified among the 34 genomes sequenced, of which 127 were missense, 74 synonymous, and one was a nonsense mutation. Among the missense mutations, C14408T, A23403G, T27299C, G28881A G28883C, and T29148C were the most prevalent within the dataset. Although SARS-CoV-2 sequencing data was limited in 2020, our results could provide insights to better understand the genetic diversity of the circulating lineages in Ceará.
The Effect of Maternal Intact Protein- and Amino Acid-Based Diets on Development of Food Intake Regulatory Systems and Body Weight in Dams and Male Offspring of Wistar Rats

The objective of this study is to examine the effect of maternal and weaning intact protein- and amino acid-based diets on regulation of food intake, intake regulatory hormones, and body weight in dams and their male offspring. Pregnant Wistar rats were allocated to two groups (n = 12) and were fed either an intact protein diet (IPD) or mixed amino acid diet (AAD) from day 3 of gestation throughout gestation and lactation. Male offspring were weaned to either an IPD or AAD for 18 weeks. Food intake (FI) and body weight (BW) were measured weekly. Results: In dams, the AAD group had lower FI and BW in the post-partum period compared with the IPD group. In pups born to AAD dams, birth weight and BW were lower. However, the percentage of fat and lean mass were not affected. Food intake was influenced by maternal diet and was higher in pups born to IPD dams throughout post-weaning. Short-term FI in response to protein preloads was lower in pups born to AAD dams in 1 h. Fasting plasma concentrations of glucose, insulin, and ghrelin were not influenced by either maternal or weaning diet. However, peptide YY (PYY) was higher in pups born to IPD dams at weaning. Conclusions: The physicochemical properties of proteins fed during pregnancy and lactation had determining effects on the body weight and development of food intake regulatory systems in offspring. Maternal AAD resulted in lower BW in dams and lower birth weight and post-weaning BWs in pups compared with maternal IPD which was consistent with their lower FI.
Prophylactic and therapeutic strategies for Epstein–Barr virus-associated diseases: emerging strategies for clinical development

ABSTRACT Introduction: Epstein–Barr virus (EBV) infects more than 95% of the world’s population and is associated with infectious mononucleosis as well as a number of cancers in various geographical locations. Despite its significant health burden, no licenced prophylactic or therapeutic vaccines are available. Areas covered: Over the last two decades, our understanding of the role of EBV infection in the pathogenesis and immune regulation of EBV-associated diseases has provided new lines of research to conceptualize various novel prophylactic and therapeutic approaches to control EBV-associated disease. In this review, we evaluate the prophylactic and therapeutic vaccine approaches against EBV and various immunotherapeutic strategies against a number of EBV-associated malignancies. This review also describes the existing and future prospects of improved EBV-targeted therapeutic strategies. Expert opinion: It is anticipated that these emerging strategies will provide answers for the major challenges in EBV vaccine development and help improve the efficacy of novel therapeutic strategies.
COVID-19 Pandemic: Another Source of Stress for Medical Students

Introduction The COVID-19 pandemic has completely changed the experience of higher education with potentially negative consequences for students’ wellbeing. Objectives To compare medicine/dentistry students’ depression/anxiety/stress levels before versus during the pandemic and to analyse the role of COVID-19-related stressors in their psychological distress. Methods Students from the Faculty of Medicine University of Coimbra answered socio-demographic and personality questionnaires and the Depression, Anxiety and Stress Scale/DASS before (academic years 2016-2017-2018-2019 - SAMPLE1; n=1000) and during (September-December 2020 and January-March 2021 - SAMPLE2; n=650) the COVID-19 pandemic. Mean age (21.12±3.75), personality traits scores, and gender proportions (»75% girls) did not significantly differ between samples. SAMPLE2 also filled in the Fear of COVID-19 Scale and a new version of the Inventory of Sources of Stress During Medical Education/ISSDME, containing a COVID-19 -related dimension (restrictions on training and on socializing with friends/colleagues). Results SAMPLE2 presented significantly higher mean scores of depression (3.89±3.55vs.3.33±3.34), anxiety (3.27±4.08vs.2.86±3.29), stress (7.07±5.72vs.6.18±4.59) and total DASS (12.28±10.55vs.13.65±11.13) than SAMPLE1 (all p<.05). Fear of COVID-19 was a significant predictor of DASS score (adjusted R2=2.9%, p<.001). COVID-19-related stressors continued explaining significant increments of DASS variance after controlling for each of the ISSDME dimensions: Course demands (R2 Change=1.8%), Human demands (2.5%), Lifestyle (2.3%), Academic competition (5.5%), and Academic adjustment (5.2%) (all p<.001). Conclusions This study adds to the evidence of the negative impact of COVID-19 on students and emphasizes its pernicious role on medical students’ psychological distress, which is already higher due to the individual and academic stressors to which they are more exposed. Disclosure No significant relationships.
Preliminary evidence for a Theory of Mind impairment in patients with Anxiety Disorders

Introduction Theory of Mind is defined as the ability to understand mental states of other people, and is notoriously impaired in patients with Autism Spectrum Disorder. A growing body of evidence suggests an impairment of Theory of Mind in several other psychopathological disorders. However, only few studies have assessed Theory of Mind in patients with Anxiety Disorders (AD), addressing only patients with Social Anxiety Disorder. Objectives We aimed to investigate the differences in Theory of Mind between patients with AD and Healthy Controls (HC). Methods We enrolled 35 patients admitted in the Psychiatric Unit of Careggi with diagnosis of AD and 31 HC. We administered them: Zung Anxiety Scale (ZSAS), Empathy Quotient (EQ), Reading the Mind in the Eyes (RMET), and Faux Pas test (FP). A t-test for independent samples was performed to assess between-group differences. Results Zung total scores proved to be significantly higher in patients (t(60)=4.375, p<0.001), while Empathy Quotient total scores (t(61)=-3.325, p=0.002), detection of faux pas in Faux Pas test (t(61)=-4.957, p<0.001), RMET total scores (t(63)=-2.269, p=0.031) were significantly higher in healthy controls. Conclusions Such preliminary data suggest impairment of Theory of Mind and Empathy in patients with AD as compared to HC. This could be linked to the development and maintenance of anxiety symptoms in patients with AD, making Theory of Mind a potential target in psychotherapy of AD. Disclosure No significant relationships.
QCD in heavy ion collisions

These lectures provide a modern introduction to selected topics in the physics of ultrarelativistic heavy ion collisions which shed light on the fundamental theory of strong interactions, the Quantum Chromodynamics. The emphasis is on the partonic forms of QCD matter which exist in the early and intermediate stages of a collision -- the colour glass condensate, the glasma, and the quark-gluon plasma -- and on the effective theories that are used for their description. These theories provide qualitative and even quantitative insight into a wealth of remarkable phenomena observed in nucleus-nucleus or deuteron-nucleus collisions at RHIC and/or the LHC, like the suppression of particle production and of azimuthal correlations at forward rapidities, the energy and centrality dependence of the multiplicities, the ridge effect, the limiting fragmentation, the jet quenching, or the dijet asymmetry.
BH-mean curvature in Randers spaces with anisotropically scaled metric

Novel 3-(substituted)-3-methyl-4-thia-1-azabicyclo[3.2. 0]heptane-2-carboxylate, 4,4-dioxides which are of value for use in combination with beta -lactam antibiotics to increase the effectiveness of the antibiotics.
Comparative

explore. The course will begin by reviewing Foucault's final lectures on parrhesia and "the courage of truth. " It will then examine some of the ancient Greek and Christian texts that Foucault analyzed. It will go on to consider early modern instances of parrhesia (e.g. Galileo and Descartes) and will conclude by surveying relatively recent versions (e.g. Greta von Thunberg and James Comey, JD'85), including contemporary feminist and queer practices of parrhesia. Lectures and discussions in English. No prerequisites. epic this introductory answers to this on the ways epics the human relationship to We read the epics through the relationships of its central characters-humans, heroes, and gods. By following the winding quests and gory battles of these narratives, students examine how epics present various forms of human-divine relationships-transactional, intimate, inspirational, and manipulative. We employ a comparative approach to the our readings originate in different regions and historical periods-from ancient India and Greece to England, and the contemporary US. We will read these texts closely and examine how they reflect particular views of the human condition within religious worldviews. Considering the contexts of post- colonization, nationalism, and globalization, we analyze how mass media-comic books, TV series, films, and social media-shape and spread those to new one of the first publications Dostoevsky after Siberian exile. We will read and discuss the novel in Russian. We will explore Dostoevsky's philosophical, religious, and political views, as they are manifested through his design of the plot and characters. Near-native competence in Russian is required. at the How does it feel to leave a world behind? Are we already trained in this experience as readers of fictions, who leave worlds behind whenever we put down a book? Can this experience of imperfectly moving on from one world to another, whether the real world or that of another fiction, teach us anything about ourselves as human beings navigating the epochal shifts of climate change and late-stage capitalism? What narrative strategies emphasize the affective and embodied dimensions of entering and exiting from their fictional worlds? We will start answering these questions by reading J. G. Ballard's The Drowned World, Giorgio Bassani's The Garden of the Finzi-Contini, and Anna Tsing's The Mushroom at the End of the World. Other course texts will be determined by student interests. Secondary and theoretical material will be drawn from a range of writers including Didi-Huberman, Berlant, Eve Kosofsky Heise, Amitav Ghosh, and K. Le Guin. This is a theory-oriented course that does not require previous knowledge. Students will have the option of producing a creative final project instead of a paper.
Facing the future: challenges and opportunities in adoptive T cell therapy in cancer

ABSTRACT Introduction: In recent years, immunotherapy for the treatment of solid cancer has emerged as a promising therapeutic alternative. Adoptive cell therapy (ACT), especially T cell-based, has been found to cause tumor regression and even cure in a percentage of treated patients. Checkpoint inhibitors further underscore the potential of the T cell compartment in the treatment of cancer. Not all patients respond to these treatments; however, many challenges remain. Areas covered: This review covers the challenges and progress in tumor antigen target identification and selection, and cell product manufacturing for T cell ACT. Tumor immune escape mechanisms and strategies to overcome those in the context of T cell ACT are also discussed. Expert opinion: The immunotherapy toolbox is rapidly expanding and improving, and the future promises further breakthroughs in the T cell ACT field. The heterogeneity of the tumor microenvironment and the multiplicity of tumor immune escape mechanisms pose formidable challenges to successful T cell immunotherapy in solid tumors, however. Individualized approaches and strategies combining treatments targeting different immunotherapeutic aspects will be needed in order to expand the applicability and improve the response rates in future.
Evaluation of stress and coping skills of nursing students during a COVID-19 pandemic

Introduction The coronavirus epidemic started in Tunisia in March 2020. Health personnel have been in the front line in the fight against this virus since that date. The COVID units of the hospitals and the different hospital services have been reinforced by student nurses (trainees, volunteers…). Objectives To evaluate the degree of stress perceived during the COVID-19 pandemic by student nurses. To identify coping skills during a COVID-19 pandemic. Methods Descriptive, retrospective study conducted in March 2021 on the 60 senior nursing students enrolled in the military health school. We used the Cungi (1997) stress scale and developed a self-questionnaire on coping skills used by the students. Results Our population was 54.3% male and 45.7% female. The average age was 22.6 years. The majority of the senior students (54.3%) worked in units dedicated to the care of patients with COVID-19. On the Cungi Stress Rating Scale, students had very low (13%), low (27%), and high (60%) stress levels. The main coping methods used were watching movies and listening to music (81%), playing sports (80%), praying (75%), rigorously applying social distancing measures and wearing protective gear (73%), talking with friends or psychologists (62%), doing yoga or meditation (34%), drinking herbal tea, alcohol, or taking psychotropic drugs (23%). Conclusions The COVID-19 pandemic is a time of major stress for nursing students. The coping methods used seem insufficient. Psychological support should be provided. Disclosure No significant relationships.