Miracle-dz/UniFAR-FTUs huggingface dataset:
X-ray Photoelectron Spectroscopy Analysis of Scandia-Ceria-Stabilized Zirconia Composites with Different Transport Properties

This work aims to study a possible modification in the electronic structure of scandia-ceria-stabilized zirconia (10Sc1CeSZ) ceramics sintered at different temperatures. In addition to using X-ray diffraction (XRD), scanning electron microscopy (SEM) and impedance spectroscopy to investigate the structural and electrical properties, we employed X-ray photoelectron spectroscopy (XPS) to determine the chemical state information of the atoms involved, along with compositional analysis. As expected, a significant increase in grain ionic conductivity with the sintering temperature was present. This increase was accompanied by a decrease in the porosity of the samples, an increase in the grain size, and a transformation from the rhombohedral to the cubic phase. The phase transformation was detected not only using XRD, but also using XPS and, for this type of ceramic, XPS detected this transformation for the first time. In addition to the changes in the structural characteristics, the increase in the ionic conductivity was accompanied by a modification in the electronic structure of the ceramic surface. The XPS results showed that the surface of the ceramic sintered at the lower temperature of 1100 °C had a higher amount of Zr–OH bonds than the surface of the ceramic sintered at the higher temperature of 1400 °C. The existence of these Zr–OH bonds was confirmed using Fourier-transform infrared spectroscopy (FTIR). From this result, taken together with the difference between the oxygen/zirconium ratios in these ceramics, also identified using XPS, we conclude that there were fewer oxygen vacancies in the ceramic sintered at the lower temperature. It is argued that these two factors, together with the changes in the structural characteristics, have a direct influence on the conductive properties of the studied ceramics sintered at different temperatures.
Risk Management and Derivatives Losses

: Even though financial risk management has the ability to generate value, the use of financial derivatives among nonfinancial corporations remains limited. We identify a channel that contributes to this limited use: the decoupling of derivatives losses and operational gains. Specifically, firms ex post consider their operational profits separately from their derivatives profits. We explore this phenomenon among firms in Mexico. We use the universe of US dollar-Mexican peso currency derivatives transactions in Mexico along with customs data to construct a unique data set on operational exchange rate exposure and financial hedging. We find that contrary to a rational and frictionless benchmark, performance in previous derivatives transactions predicts future derivatives use. Using a regression kink design to measure the impact of decoupling on risk management, we find that when losses from previous transactions increase 1 percentage point, firms become 4.24 percentage points less likely to take out a new derivatives position within 90 days. We provide further evidence that is consistent with decoupling and supports rejecting a net worth channel.
Risk of venous thromboembolism in patients with cancer treated with Cisplatin: a systematic review and meta-analysis.

PURPOSE Several reports suggest that cisplatin is associated with an increased risk of thromboembolism. However, because the excess risk of venous thromboembolic events (VTEs) with cisplatin-based chemotherapy has not been well described, we conducted a systemic review and meta-analysis of randomized controlled trials evaluating the incidence and risk of VTEs associated with cisplatin-based chemotherapy. METHODS PubMed was searched for articles published from January 1, 1990, to December 31, 2010. Eligible studies included prospective randomized phase II and III trials evaluating cisplatin-based versus non-cisplatin-based chemotherapy in patients with solid tumors. Data on all-grade VTEs were extracted. Study quality was calculated using Jadad scores. Incidence rates, relative risks (RRs), and 95% CIs were calculated using a random effects model. RESULTS A total of 8,216 patients with various advanced solid tumors from 38 randomized controlled trials were included. The incidence of VTEs was 1.92% (95% CI, 1.07 to 2.76) in patients treated with cisplatin-based chemotherapy and 0.79% (95% CI, 0.45 to 1.13) in patients treated with non-cisplatin-based regimens. Patients receiving cisplatin-based chemotherapy had a significantly increased risk of VTEs (RR, 1.67; 95% CI, 1.25 to 2.23; P = .01). Exploratory subgroup analysis revealed the highest RR of VTEs in patients receiving a weekly equivalent cisplatin dose > 30 mg/m(2) (2.71; 95% CI, 1.17 to 6.30; P = .02) and in trials reported during 2000 to 2010 (1.72; 95% CI, 1.27 to 2.34; P = .01). CONCLUSION Cisplatin is associated with a significant increase in the risk of VTEs in patients with advanced solid tumors when compared with non-cisplatin-based chemotherapy.
Comparing Depression Prevalence and Associated Symptoms with Intolerance of Uncertainty among Chinese Urban and Rural Adolescents: A Network Analysis

The prevalence of depression among adolescents is increasing, which can hinder their healthy development and is intricately linked to the intolerance of uncertainty (IU). IU involves both prospective anxiety and inhibitory anxiety. However, the precise relationship between depressive symptoms and these two components of IU remains unclear, particularly when considering the specific context of rural adolescents in China. A total of 1488 adolescents (male, 848; Meanage = 20, SDage = 1.51, age range from 16 to 24) in China were recruited and divided into urban adolescents (N = 439) and rural adolescents (N = 1049) groups. The Patient Health Questionnaire-9 and Intolerance of Uncertainty Scale-12 were utilized to measure depression and IU. The symptom network approach and the flow network approach were employed. The prevalence of depression was significantly higher (χ2 = 4.09, p = 0.04) among rural adolescents (N = 419, 40.1%) than urban adolescents (N = 152, 34.8%). The node strength of “motor” demonstrated some discrepancy between rural and urban adolescents, while there was no notable disparity in the global strength and structure of the network between the two groups. However, rural adolescents exhibited a significantly higher global strength in the flow network (including depression and IU) than their urban counterparts. In the flow networks of rural adolescents, “guilt” was directly associated with prospective and inhibitory anxiety. These findings highlight the urgent need for interventions that enhance the ability of rural adolescents to cope with uncertainty and prevent their depressive symptoms more effectively.
Eosinophilic dermatosis of hematologic malignancy in patients with chronic lymphocytic leukemia/non-Hodgkin’s B lymphoma: a single center prospective clinico-pathological study

Background The pathogenesis of eosinophilic dermatosis of hematologic malignancy (EDHM) is poorly understood. Previously thought to be a hypersensitivity reaction to insect bites, immune dysregulation and cytokine imbalance are now thought to be responsible. Its prognostic significance is unclear. Objective To describe the clinical, pathological and immunological findings in a series of oncohematological patients with EDHM. Methods An observational prospective cohort study of oncohematological patients receiving a diagnosis of EDHM between April 2017 and December 2018. Results A total of 15 patients with EDHM (10 females and 5 males) were identified among 422 oncohematological patients. Disease presentation varied from firm erythematous papules to more polymorphic presentations. The lesions were most prevalent on the exposed sites, 8/15 patients recalled an insect bite. Lesion seasonality was reported in 13/15 patients. IgE levels were elevated in six patients, circulating IL-4 and IL-5 were within a normal range. Twelve out of 15 patients developed skin manifestations after chemotherapy. The infiltrate could be eosinophil-rich or lymphocytic-rich. Interestingly, the histopathologic findings were in accordance with arthropod bites. Conclusion A role for insect bites in EDHM is supported by our findings. EDHM may be related to aggressive hematologic disease.
Immunolocalization and Expression of JAK1 and JAK3 in the Skin of Dust Mite-Sensitive Beagle Dogs before and after Allergen Exposure

Simple Summary Our study aimed to stain a cellular pathway that is a potential target of drugs to treat allergies. In our study, we took skin samples from dogs allergic to dust, before and after exposure to dust mites, and stained those samples for this pathway. We found that this pathway was present in skin cells and that exposure to the dust mites changed how this pathway was expressed. These results confirm that this pathway plays a role in the course of allergic responses and that topical creams targeting this pathway can be promising to treat allergic skin disease. Abstract Janus kinase (JAK) pathways have emerged as targets of treatment, yet localization and expression of JAK1 and JAK3 in canine atopic skin have not been studied. This study aimed to compare the localization and expression of JAK1 and JAK3 in the skin of atopic dogs before and after allergen exposure. Skin biopsies taken from atopic beagles sensitized to house dust mites (HDM) before (D0) and after four weeks (D28) of allergen exposure were stained. Staining was subjectively scored by examiners unaware of the source of the slides. Image J was used for the semiquantitative assessment of staining intensity. JAK1 and JAK3 staining was epidermal and dermal. JAK1 staining was cytoplasmic, primarily found in basal keratinocytes and dermal cells, while JAK 3 was nuclear (all epidermal levels and on dermal inflammatory cells). Epidermal thickness was significantly higher on D28 than on D0 (p < 0.0001). For JAK1, epidermal staining divided by epithelial thickness was significantly lower on D28 (p = 0.0002) compared to D0. For JAK3 staining, intensity in the dermis was significantly higher on D28 (p = 0.0405) compared to D0. We conclude that decreased expression of JAK1 in the epidermis and increased expression of JAK3 in the dermis of atopic dogs occur after allergen exposure.
Novel Aspects of cAMP-Response Element Modulator (CREM) Role in Spermatogenesis and Male Fertility

Spermatogenesis is a very complex process with an intricate transcriptional regulation. The transition from the diploid to the haploid state requires the involvement of specialized genes in meiosis, among other specific functions for the formation of the spermatozoon. The transcription factor cAMP-response element modulator (CREM) is a key modulator that triggers the differentiation of the germ cell into the spermatozoon through the modification of gene expression. CREM has multiple repressor and activator isoforms whose expression is tissue-cell-type specific and tightly regulated by various factors at the transcriptional, post-transcriptional and post-translational level. The activator isoform CREMτ controls the expression of several relevant genes in post-meiotic stages of spermatogenesis. In addition, exposure to xenobiotics negatively affects CREMτ expression, which is linked to male infertility. On the other hand, antioxidants could have a positive effect on CREMτ expression and improve sperm parameters in idiopathically infertile men. Therefore, CREM expression could be used as a biomarker to detect and even counteract male infertility. This review examines the importance of CREM as a transcription factor for sperm production and its relevance in male fertility, infertility and the response to environmental xenobiotics that may affect CREMτ expression and the downstream regulation that alters male fertility. Also, some health disorders in which CREM expression is altered are discussed.
on Gastrointestinal Imaging

Procedure Appropriateness Category Relative Radiation Level CT abdomen and pelvis with IV contrast Usually Appropriate ☢☢☢ US abdomen May Be Appropriate O US pelvis May Be Appropriate O MRI abdomen and pelvis without and with IV contrast May Be Appropriate O MRI abdomen and pelvis without IV contrast May Be Appropriate O CT abdomen and pelvis without IV contrast May Be Appropriate ☢☢☢ Radiography abdomen Usually Not Appropriate ☢☢ Fluoroscopy contrast enema Usually Not Appropriate ☢☢☢ CT abdomen and pelvis without and with IV contrast Usually Not Appropriate ☢☢☢☢ WBC scan abdomen and pelvis Usually Not Appropriate ☢☢☢☢
Autorregulación del Aprendizaje y Autoeficacia Académica: Correlación con el rendimiento académico en estudiantes de ingeniería

El objetivo de la presente investigación es determinar las influencias de la autorregulación del aprendizaje y la autoeficacia académica en el rendimiento académico en estudiantes de ingeniería en modalidad virtual durante el año 2021. La muestra está compuesta por 76 estudiantes de las ingenierías civiles eléctrica, informática e industrial de la Universidad de Tarapacá sede Iquique. Se utilizaron dos cuestionarios validados en Chile. Para medir autorregulación del aprendizaje se utilizó la versión traducida del Cuestionario de Autorregulación del Aprendizaje en Línea (OSLQ), mientras que para la autoeficacia académica se utilizó el cuestionario Escala de Autoeficacia Percibida Específica de Situaciones Académicas (EAPESA). El rendimiento académico corresponde al promedio de calificaciones obtenido el primer semestre 2021. Los resultados indican que no se hallaron correlaciones significativas entre las variables de la autorregulación del aprendizaje y la autoeficacia académica con el rendimiento académico en los estudiantes de ingeniería. Sin embargo, se determinaron correlaciones significativas dentro de las subescalas de la autorregulación del aprendizaje en los estudiantes de primer y segundo año. Se concluyó que no existen influencias de los factores de la autorregulación del aprendizaje y la autoeficacia académica percibida en el rendimiento académico de la muestra.
Bortezomib‐Cyclophosphamide‐Dexamethasone (VCD) versus Bortezomib‐Thalidomide‐Dexamethasone (VTD) ‐based regimens as induction therapies in newly diagnosed transplant eligible patients with multiple myeloma: a meta‐analysis

Three‐drug induction regimens have become the standard of care in newly diagnosed transplant‐eligible multiple myeloma patients. Two frequently used protocols are bortezomib, cyclophosphamide and dexamethasone (VCD) and bortezomib, thalidomide and dexamethasone (VTD). Comparisons between the two are lacking. The present study aimed to identify the differences in response rate and toxicity between the two regimens. Databases were searched using the terms ‘VTD’ or ‘VCD’ and ‘induction regimens for newly diagnosed multiple myeloma’. Prospective trials evaluating initial response in transplant eligible patients were included. The main outcome measures were response rates and adverse events. Eight clinical trials were eligible for analysis. Overall 672 patients were treated with either VCD (n = 157) or VTD (n = 515) as induction therapy. Patients treated with VTD presented with a significantly higher complete/near complete response (34% vs. 6%, P = 0·002) as well as a higher very good partial response rate or better, following induction therapy (62% vs. 27%, P < 0·0001). Although grade 3–4 neurotoxicity was more frequent during VTD therapy (11% vs. 6%, P = 0·057), a higher incidence of overall grade 3–4 adverse events was found in the VCD‐treated patients (74% vs. 51%, P < 0·001). VTD induction therapy may be superior in achieving deeper response rate following induction therapy, and is better tolerated.
Foraminifera of the Midway formation in Texas

Includes 13 figures. Accompanied by 15 plates -- Plate 1 : Map showing locations of stations where Midway outcrops were sampled, Table : Distribution of Midway species of foraminifera from stations 1 to 85 along the belt of outcrop of the formation in Texas. Plate 2 : Figures of a few Navarro foraminifera. Plates 3-15 : Figures of Midway foraminifera. University of Texas bulletin. no. 2644 : Nov. 22, 1926
Effect of different tillage methods on root yield and yield components of sugar beet (Beta vulgaris).

A two-year field experiment was conducted at the Research Site of Hamedan Agricultural and Natural Resources Research Center, Hamedan, Iran on the loam soils to study the effect of different tillage methods on root yield and yield components of sugar beet (Beta vulgaris) during 2008 and 2009 growing seasons. Tillage treatments in the study were moldboard plow + two passes of disk harrow (MDD) as conventional tillage method; moldboard plow + one pass of rotavator (MR), chisel plow + one pass of rotavator (CR) and two passes of disk harrow (DD) as reduced tillage methods; one pass of rotavator (R) and one pass of tine cultivator (C) as minimum tillage methods, and no-tillage (NT) as direct drilling method. Root yield (RY) and some yield components such as root number per hectare (RNPH), sugar yield (SUGY), root dry matter (RODM), root length (ROTL), rim diameter (RIMD) were determined for all treatments. Different tillage methods significantly (P # 0.05) affected RNPH, but there was no significant difference in other studied traits. Although there was no significant difference in RY, SUGY, RODM, ROTL and RIMD, results of the study showed that tillage practices were beneficial in improving the yield of sugar beet. The maximum values of RY (82.7 t ha), RNPH (135412 roots ha), SUGY (11.4 t ha) and RODM (23.9%) were observed in case of MR treatment, while the maximum values of ROTL (20.5 cm) and RIMD (1.5 cm) were noted in case of NT treatment. In contrast, the minimum values of RY (71.3 t ha), RNPH (115000 roots ha), SUGY (9.15 t ha) and RODM (20.3%) were observed in case of NT treatment, while the minimum values of ROTL (18.0 cm) and RIMD (1.1 cm) were noted in case of MR treatment. Results also showed that tillage method affected the yield of sugar beet in the order of MR > CR > R > MDD > DD > C > NT. Therefore, the reduced tillage treatments MR and CR, and the minimum tillage treatment R were considered as more appropriate and profitable tillage methods in improving the yield of sugar beet.
Middle atmospheric temperature measurements using ground based lidar from low latitude

Lidar measurements of atmospheric density and temperature in the altitude range 30-80 km have been performed during the period March-December 1998, using NMRF-IJL, Gadanki (13.8 deg N, 79.2 deg E). Sample results on temperature structures in the periods of equinoctial, summer and winter nights, results on wave propagation and evidence of mesospheric temperature inversion on an occasion are presented. The data analysis, method of temperature determination and its standard error are also described.
EXPECTATIONS OF UNIVERSITY LECTURERS AND STUDENTS ON SMART LEARNING ENVIRONMENTS

Education in the 21st century has become more technology integrated, and the shift from conventional modalities of teaching to technology-assisted teaching methodologies accelerated during the pandemic years. The current study employed a qualitative research design (n=12) to explore this shift and the expectations of these novel teaching modalities from both facilitator and learner perspectives in urban higher education settings in India. An inductive thematic analysis of the qualitative data revealed that there is a significant gap in lecturers’ and students’ definitions and expectations of smart learning environments. The themes that emerged from the data were bifurcated into lecturer and student perspectives on smart learning environments and included innovative nature, novelty and complexity, student excitement, and limitations of content. Based on the findings, lecturer and student expectations of SLE platforms had points of convergence and divergence which are unique to the socio-cultural positions of the participants. The current study argues the need to devise methods to improve the efficacy of SLEs in developing economies. Keywords: smart learning environments, augmented reality, virtual reality, qualitative study
Calibration of a physics-based human gastric emptying model

: The rate of gastric (or stomach) emptying following a meal has important implications for health, including satiety and blood glucose regulation, which relate to obesity and diabetes, and the development of new drug delivery systems. This process is driven by the pressure gradient between the stomach and the duodenum, which is generated by various motility mechanisms such as tonic contraction, antral contraction waves (ACWs), and periodic opening and closing of the pyloric sphincter. Current experimental methods, such as magnetic resonance imaging (MRI), do not accurately measure the emptying rate and all the different aspects of gastric motility simultaneously. Therefore, it remains unclear to what extent the various motility mechanisms independently regulate and affect gastric emptying rate. This study employs a Smoothed-Particle Hydrodynamics (SPH) based computational model to investigate gastric emptying and uses the results of an MRI based experiment to calibrate the stomach-duodenum pressure gradient along with opening diameter of the pyloric sphincter. The model comprises a realistic 3D surface mesh of the stomach with all major geometric features. Motility mechanisms, such as antral contraction waves (ACWs) and a periodically opening pylorus, are simulated as prescribed deformations of the surface mesh (Figure 1). To simulate the MRI experiment, we integrated as much information about the motility patterns as possible from the MRI analysis. However, sufficient data on two critical parameters was not available: (i) the maximum opening diameter of the pylorus (D max ), and (ii) the value of back-pressure (P D ) applied in the proximal duodenum (Figure 1). Hence, these parameters were calibrated to match the experimental emptying rate, which allowed for an investigation into the interplay between these parameters and understanding of their impact on the gastric emptying rate. The simulation results show that the gastric emptying rate, characterised by emptying half time, is strongly affected by the back pressure, and less affected by the opening diameter of the pylorus. Specifically, the emptying half-time is only moderately affected by D max when P D is low, while the effect of D max is negligible when P D is high. The model-predicted emptying half-times showed the closest agreement with the estimation from Marciani et al.’s experiment when P D was set to 700 Pa and D max to 20 mm. Flow results (shown below) confirm the presence of flow features that are observed by other similar studies, suggesting that current results are valid. These include eddies near the ACWs along the bottom surface of the stomach during pyloric opening and strong upward currents in the same location after pyloric closure. Future extensions of the model will include dynamic solid objects in the gastric content and simulations of longer periods of emptying