Miracle-dz/UniFAR-FTUs huggingface dataset:
Analisis Pengelolaan Obat Di Instalasi Rawat Inap Rumah Sakit Jantung Bina Waluya Jakarta Timur Tahun 2019

Pengelolaan persediaan obat adalah suatu sistem yang sangat penting dalam mendukung pengelolaan barang dan jasa. Peran terpenting pada sistem persediaan yaitu untuk memperlancar kegiatan operasional. Kekurangan obat akan mengakibatkan terlambatnya pelayanan pasien. Ketersediaan obat yang tepat pada waktu yang tepat dan tempat yang tepat akan membantu tujuan organisasi dalam melayani pasien, produktivitas, keuntungan dan kembali modal. Rumah Sakit Jantung Binawaluya Jakarta Timur telah menerapkan pengelolaan persediaan obat. Penelitian ini bertujuan menganalisis input dan proses pengelolaan obat di instalasi rawat inap Rumah Sakit Jantung Binawaluya Jakarta Timur Tahun 2019. Jenis penelitian ini adalah penelitian kualitatif dengan pendekatan sistem. Penentuan informan menggunakan metode purposive sampling dan diperoleh informan sebanyak 4 orang. Keabsahan data dilakukan dengan triangulasi sumber dan triangulasi teknik. Hasil penelitian ini menunjukan bahwa keadaan SDM dari segi kuantitas telah mencukupi, tetapi kualitasnya masih perlu ditingkatkan. Ketersediaan fasilitas masih belum mencukupi. Proses perencanaan dan pengadaan persediaan obat dilakukan setiap saat ketika persediaan obat mencapai titik pemesanan. Proses penyimpanan masih terkendala masalah fasilitas yang masih perlu ditingkatkan. Pendistribusian dilakukan dengan UDD. Pengawasan dan pengendalian dilakukan secara periodik dan berkelanjutan. Berdasarkan hasil penelitian tersebut, disarankan agar dilakukan analisis kebutuhan pelatihan bagi SDM terkait pengelolaan obat. Diperlukan adanya penambahan fasilitas penyimpanan obat serta perlu dipertimbangkan adanya SIM RS terpadu
Emerging and Developing Economies: Ten Years after the Global Recession

Although emerging market and developing economies (EMDEs) weathered the global recession a decade ago relatively well, they now appear less well placed to cope with the substantial downside risks facing the global economy. In many EMDEs, the room for monetary and fiscal policies to respond to shocks has eroded; underlying growth potential has slowed; and the momentum for improving policy frameworks, institutions, and business climates seems to have slackened. The experience of the 2009 global recession highlights once again the critical role of policy room in shielding economic activity during adverse shocks. The subsequent decade of anemic growth underlines the need for sound policy frameworks, institutions, and business environments to promote sustained growth. With the global growth outlook weakening and vulnerabilities rising, the policy priority for EMDEs is now to improve resilience to shocks and to lift long-term growth prospects.
on Neurological Imaging

Procedure Appropriateness Category Relative Radiation Level CT head without IV contrast Usually Appropriate ☢☢☢ MRI head without IV contrast Usually Appropriate O MRI head without and with IV contrast May Be Appropriate O CT head with IV contrast Usually Not Appropriate ☢☢☢ CT head without and with IV contrast Usually Not Appropriate ☢☢☢ FDG-PET/CT brain Usually Not Appropriate ☢☢☢ MEG Usually Not Appropriate O MRI functional (fMRI) head without IV contrast Usually Not Appropriate O HMPAO SPECT or SPECT/CT brain ictal and interictal Usually Not Appropriate ☢☢☢
The Apex of Amphicyonid Hypercarnivory: Solving The Riddle of Agnotherium antiquum Kaup, 1833 (Mammalia, Carnivora)

ABSTRACT Since its first description, only a single undisputed specimen, an isolated, highly abraded m1, was known from the enigmatic amphicyonid Agnotherium antiquum Kaup, 1833. Here, we describe the second specimen of A. antiquum from the type locality of Eppelsheim (early late Miocene, MN 9/10 of Germany), unearthed 184 years after the first description of A. antiquum. The specimen consists of a partial left juvenile mandible with dp3, m1 in eruption, i3, canine, p4, and a highly reduced m2 still in crypt. The p1–3 and m3 are completely reduced, as are the metaconids of m1 and m2. We confirm previous assignments of late Miocene specimens from the localities of Charmoille, Switzerland, and Pedregueras 2A, Spain, to A. antiquum, whereas a maxilla from Bled Douarah, Tunisia, can only tentatively be assigned to the species. We confirm that the monotypic genus Agnotherium is a thaumastocyonine amphicyonid, discuss other supposed thaumastocyonine specimens, and briefly review the evolutionary history of the subfamily. Agnotherium was a 275 kg, extremely powerful, strictly carnivorous ambush hunter that represents the apex of amphicyonid evolution toward carnivory. Its tooth eruption pattern resembles recent Ursus more than recent Canis, but it shows a considerable delay of eruption timing like in the ursid Agriotherium. Agnotherium antiquum is one of six carnivoran species from the Eppelsheim Formation that is heavier than 200 kg. The co-occurrence of Agnotherium (or its relatives Tomocyon and Thaumastocyon), Machairodus, and a smaller saber-toothed carnivoran is typical for early late Miocene faunas of Europe and tentatively North Africa.
The Downstream Targets of MYB-Type Transcription Factors Involved in Suberin Biosynthesis

Suberin is a lipid- and phenolic-based heteropolymer that is deposited in the cell walls of certain plant tissues to act as a physical barrier against unregulated gas, water, or solute movement. Suberin deposition in root endodermis is regulated by MYB-type transcription factors, and under non-stress conditions these include AtMYB53, AtMYB92 and AtMYB93 in Arabidopsis. The transcriptional targets of these MYBs have not been previously reported. In this thesis, the transcriptomes of two Arabidopsis triple knockout myb53-myb92-myb93 mutants were compared to 14-day old wild-type seedlings using RNA-seq. Also, the transcriptome of a steroid-inducible AtMYB53 overexpression line was compared to an uninduced control in 10-day old seedlings. From these analyses, GDSL-type esterases / acyltransferases, an HXXXD-type (BAHD) acyl-transferase, additional MYB-type transcription factors, a WRKY transcription factor, ABCG-type transporters, and CASP-like assembly proteins were identified as suberin-related genes. Additionally, sequential C-terminal deletions of each of these MYBs revealed important regions for their activity.
Heterogeneous Effects of Unconventional Monetary Policy on the Bond Yields across the Euro Area

This paper investigates the impact of European Central Bank's unconventional monetary policies between 2008-2016 on the government bond yields of eight European Monetary Union countries and up to eleven different maturities. In identifying this impact, it adopts a novel econometric approach that combines data-rich dynamic factor analysis and VAR with heteroskadasiticy based identification. This novel approach allows a single model to estimate the impact of a common unconventional monetary policy shock across different countries, maturities, yield components and over time. The results identify a significant and substantial impact for all countries and all maturities in the sample. The evidence also suggests that the impact was stronger and persistent in the periphery countries which have higher financial distress, uncertainty, country risk and lower liquidity. When we decompose the impact into separate yield components, we find that unconventional shocks decreased the common market component of the yields in all countries. As for the risk component, unconventional policies decreased it for the periphery countries permanently at the cost of a small increase in the core countries, as consistent with the international portfolio balance channel. These findings contribute to the literature by providing a comprehensive characterization of the impact of unconventional monetary policies for different economic environments.
Approche numérique pour l’optimisation personnalisée des réglages d’un fauteuil roulant manuel

L’etude de la biomecanique de la locomotion en fauteuil roulant manuel (FRM) a pour objectif de limiter le risque d’apparitions de blessures du membre superieur, en optimisant la facilite a se deplacer. De nombreuses etudes ont montre qu’un ajustement des reglages du FRM avait un impact sur la mobilite. Neanmoins, les modeles utilises dans la litterature pour representer les interactions « sujet-FRM » et « FRM-environnement » possedaient plusieurs limitations. Ainsi, l’objectif premier de la these etait la mise en place d’un modele musculo-squelettique du membre superieur permettant de modeliser l’interaction entre le sujet et le FRM, en utilisant des methodes experimentales adaptees pour appliquer ce modele. Le second objectif etait de construire un modele mecanique du FRM en mouvement permettant de calculer les forces de reaction entre le sol et les roues du FRM. Le dernier objectif etait d’appliquer une procedure d’optimisation numerique des reglages du FRM incluant les modeles developpes durant la these. Le modele musculo-squelettique developpe a permis d’analyser la biomecanique du membre superieur lors de la locomotion en FRM chez les sujets recrutes lors des campagnes de mesures. L’optimisation des reglages du FRM a ete mise en place a partir du modele mecanique du FRM, permettant de confirmer l’influence de plusieurs reglages sur la mobilite en FRM. Enfin, des perspectives d’amelioration de la procedure d’optimisation des reglages ont ete explorees, a partir d’algorithmes de generation predictive du mouvement.
I2CU: A Dedicated Im2col Hardware Unit

For Convolution Neural Network (CNN), the convolution operation for feature map and weight map usually implemented by im2col + GEMM method. However, for conventional method need expand feature map to a large feature matrix during a single kernel function based on convolution parameters (i.e. filter size, padding, and stride), then multiplication for matrixes took place in another function. Thus the conventional method will generate tons data transfer and the large feature matrix requires enormous storage space, it is hardware unfriendly.We design a hardware unit, I2CU (Im2Col Unit), a dedicated hardware unit to implement im2col in hardware friendly way. I2CU dynamically expand loaded 4D-Block return from texture unit and write back destination matrix to shared memory. I2CU can decrease the feature matrix storage space and implement im2col + GEMM in one kernel function.
Carotid artery intima media thickness in relation with atherosclerotic risk factors in patients with newly diagnosed type 2 diabetes mellitus in a rural tertiary care hospital in central India

Background: Vascular complications of atherosclerosis are major causes of morbidity and mortality in patients with type 2 diabetes mellitus (T2DM). The aim of the study was to study the correlation between carotid artery intima media thickness (CIMT) and risk factors for atherosclerosis and atherosclerotic vascular events in newly diagnosed type 2 diabetes mellitus patients with an objective to determine the predictive value of CIMT as an indicator of early atherosclerosis. Methods: The predictive value of CIMT as well as various atherosclerotic risk factors including ankle brachial index (ABI) were determined as an indicator of early atherosclerosis. Data were presented in form of percentage and proportions. Qualitative variables were tested using Chi square test and the p values were calculated between the groups having CIMT less than and more than 0.9 mm. p values of ≤0.05 were considered statistically significant. Averages were expressed between groups as mean ±standard deviation or as percentage. Multivariate analysis was done using the multiple linear regression model. Results: The study showed that though age, smoking and dyslipidemia did not show any association with CIMT; hypertension, ABI, glycosylated hemoglobin and urine albumin excretion rate had positive correlation with CIMT with statistically significant association between ABI and CIMT. Conclusions: Assessment of CIMT by B mode ultrasound is a relatively inexpensive means of measuring subclinical atherosclerosis. Present study showed that CIMT is significantly higher in those type 2 diabetic patients who had atherosclerotic events than in those type 2 diabetic patients who had only risk factors for atherosclerosis.
Perspectives and Practice: Physical Therapist Students' Clinical Reasoning

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Deep Reinforcement Learning (DRL): Another Perspective for Unsupervised Wireless Localization

Location is key to spatialize Internet of Things (IoT) data. However, it is challenging to use low-cost IoT devices for robust unsupervised localization (i.e., localization without training data that have known location labels). Thus, this article proposes a deep-reinforcement-learning (DRL)-based unsupervised wireless-localization method. The main contributions are as follows: 1) this article proposes an approach to model a continuous wireless-localization process as a Markov decision process and process it within a DRL framework; 2) to alleviate the challenge of obtaining rewards when using unlabeled data (e.g., daily life crowdsourced data), this article presents a reward-setting mechanism, which extracts robust landmark data from unlabeled wireless received signal strengths (RSS); and 3) to ease requirements for model retraining when using DRL for localization, this article uses RSS measurements together with agent location to construct DRL inputs. The proposed method is tested by using field testing data from multiple Bluetooth 5 smart ear tags in a pasture. Meanwhile, the experimental verification process reflects the advantages and challenges for using DRL in wireless localization.
Connexins 43 and 45 hemichannels and CALHM1 mediate ATP release in human urothelial RT4 cells

Hypothesis / aims of study Over the last two decades, a prominent role of ATP in bladder sensation via the activation of purinergic receptors on sensory afferent neurons to regulate urinary bladder functions under normal and pathophysiological conditions has been established. A significant rise in stretch-induced ATP release from urothelium has been reported in patients with overactive bladder and interstitial cystitis [1]. Although in animal models, such as rat, mice and porcine, ATP release from the bladder has been demonstrated to occur via many different mechanisms, including connexin (Cx)43 and Cx45 hemichannels [2] and pannexin-1 and calcium homeostasis modulator 1 (CALHM1) channels [3], the cellular pathways responsible for ATP release from human bladder are still unknown. Characterising mechanisms involved in ATP release in the human bladder could be the first critical step to develop new therapeutics for disorders associated with increased ATP release. We, therefore, aimed to determine the involvement of pannexin1, CALHM1, Cx43 and Cx45 in regulating extracellular ATP signalling in human urothelial cells. We hypothesised that pannexin1 and CALHM1 channels and connexin hemichannels are ATP release channels in the human bladder and that bladder diseases are associated with abnormal expression and function of these channels.
Numerical Investigation of Noise Generation by Automotive Cooling Fans

Electrical vehicle technology is sharply rising and expected to dominate the international market in the coming 10 years. In electric vehicles, axial cooling fans are commonly used to cool batteries with high heating load. One drawback of axial cooling fans is the high aeroacoustic noise level resulting from the fan blades and the obstacles facing the air flow. To create a comfortable cabin environment in the vehicle, a low-noise installation design of the axial fan is required. The purpose of the current project is to develop an efficient computational aeroacoustics (CAA) simulation process to assist the cooling-fan installation design. The current thesis focuses on a hybrid CAA approach where the aerodynamic field is obtained through the unsteady Reynolds-averaged Navier-Stokes equations (URANS) model, and the acoustic field is computed via Lighthill’s analogy. The simulation process is applied to a benchmark case in the literature, where the aerodynamics and aeroacoustics of a low-speed axial fan are investigated separately. Initial steady state simulation is performed using the moving reference frame (MRF) approach to quantify different simulation model parameters before running the main URANS simulation. The URANS model provides good prediction of the mean flow quantities. The computed unsteady wall pressure fluctuations succeeds to resolve the fan blade passing frequency and the sub-harmonic frequency resulted from the interaction of the gap flow with the fan blades. The CAA approach studied in this thesis is limited to the prediction of narrow-band components of the fan noise, i.e., the blade-passing-frequency (BPF) noise and the noise generated by distinct coherent vortex structures. The aeroacoustic simulation model successfully captures the narrow-band acoustic signal and gives promising results for extending the approach to predict broad-band fan noise by replacing the URANS model with more advanced CFD models, such as the large eddy simulation.
Clinical Features of Cerebral Venous Sinus Thrombosis

Amaç: Serebral venöz sinüs trombozunun (SVST) altında yatan nedenleri, hastalığın karşımıza çıkış şekillerini, görüntüleme özelliklerini, tedavi tiplerini ve hastaların akıbetlerini araştırmayı amaçladık. Gereç ve Yöntem: Eskişehir Osmangazi Üniversitesi Tıp Fakültesi, Nöroloji Anabilim Dalı, Nöroloji İnme Merkezi’nde Nisan 2011-Eylül 2016 tarihleri arasında SVST tanısı ile takip ettiğimiz hastaların demografik verileri, başvuru belirti ve bulguları, nörogörüntüleme ve laboratuvar incelemeleri, hastalığın altında yatan nedenleri, tedavi şekillerimiz ve yine hastaların hastaneden çıkarıldıkları sıradaki nörolojik fonksiyonları geriye dönük olarak incelendi. Bulgular: SVST tanılı 25’i kadın toplam 31 hasta çalışmaya dahil edildi. Hastaların yaş ortalaması 43,7 idi (standart sapma: 16,4 değişim aralığı: 22-78). En sık görülen belirti baş ağrısı olup, en sık altta yatan nedenler gebelik ve lohusalık, en sık tutulan sinüs ise transvers sinüs idi. Hastaların büyük kısmının (29/31, %93,6) antikoagüle edildiği ve taburcu edildikleri sıradaki Modifiye Rankin Skala skorlarının 2 ya da altında olduğu görüldü. Sonuç: Bu çalışmada inme merkezimizde takip ettiğimiz SVST tanılı hastaların özelliklerini inceledik ve hastaların akıbetlerinin önceden sanılanın aksine iyi olduğunu gösterdik. Ancak, tedavi şekilleri ve hastalığın akıbeti ile ilgili daha kesin sonuçlara ulaşabilmek için daha geniş kohortlu ileriye dönük çalışmalara ihtiyaç vardır. Anahtar Kelimeler: Venöz tromboz, sinüs trombozu, inme, inme alt tipi Objective: To investigate the predisposing factors for cerebral venous sinus thrombosis (CVST), presenting patterns of the disease, imaging characteristics, types of treatment, and outcomes of patients. Materials and Methods: Retrospectively, between April 2011 and September 2016 at Eskisehir Osmangazi Stroke Center, the demographic data, symptoms and findings, neuroimaging and laboratory findings of patients with CVST were collected. Additionally, predisposing factors for the disease, treatment strategies, and the neurologic functions of patients at discharge were examined. Results: Thirty-one patients with CVST were included in the study, 25 of whom were female. The mean age of the patients was 43.7 years (standard deviation: 16.4; range, 22-78 years). The most common symptom was headache and the most common predisposing factors were pregnancy and puerperium. Also, transverse sinus was the most common thrombosed sinus. In the majority of patients (29/31, 93.6%), anticoagulation was applied and the Modified Rankin Scale score was 2 or below. Conclusion: In this study, we detailed the characteristics of patients with CVST at our stroke center and contrary to previous knowledge, we showed that the outcomes of patients were good. However, to achieve more accurate conclusions about treatment strategies and outcomes, we need prospective studies with larger cohorts.
The quadratic shortest path problem

Quadratic Shortest Path Problem (QSPP) is a variation of the Shortest Path problem, where the objective function is quadratic. In addition to a cost associated with each edge in a graph, there is a cost with each pair of edges in the graph. The cost of a path is the sum of the costs of each edge in the path and the quadratic costs for each pair of edges in the path. This makes the problem NP-hard. polynomial-time algorithms are known for restricted versions of QSPP, such as Adjacent-QSPP, where the quadratic cost is only considered between adjacent pairs of vertices in the path. Integer programs with different bounds have also been discussed for QSPP with non-negative cost matrices. In this thesis, we provide integer programs for solving QSPP with arbitrary cost matrices. We compare our formulation where sub-tours are eliminated with the well-known MTZ constraints with one where sub-tours are eliminated iteratively by introducing the violated constraints only. We also provide two heuristic polynomial time solutions to the QSPP, the Basic Algorithm and the Multi Start Algorithm. We compare the Multi Start Algorithm with solutions obtained from the integer programs with MTZ constraints and show that the Multi Start Algorithm is a good heuristic to QSPP.