Miracle-dz/UniFAR-FTUs huggingface dataset:
0 O ct 2 00 5 A Characterization of Model Multi-colour Sets September 26 , 2018

Model sets are always Meyer sets, but not vice-versa. This article is about characterizing model sets (general and regular) amongst the Meyer sets in terms of two associated dynamical systems. These two dynamical systems describe two very different topologies on point sets, one local and one global. In model sets these two are strongly interconnected and this connection is essentially definitive. The paper is set in the context of multi-colour sets, that is to say, point sets in which points come in a finite number of colours, that are loosely coupled together by finite local complexity.
M. F. (2014). Weak hyperbolicity of cube complexes and quasi-arboreal groups. Journal of Topology , 7 (2), 385-418.

We examine a graph Γ encoding the intersection of hyperplane carriers in a CAT(0) cube complex e X . The main result is that Γ is quasi-isometric to a tree. This implies that a group G acting properly and cocompactly on e X is weakly hyperbolic relative to the hyperplane stabilizers. Using Wright’s recent result on the aymptotic dimension of CAT(0) cube complexes, we give a generalization of a theorem of Bell and Dranishnikov on the ﬁnite asymptotic dimension of graphs of asymptotically ﬁnite-dimensional groups. Finally, we apply contact graph techniques to prove a cubical version of the ﬂat plane theorem stated in terms of complete bipartite subgraphs of Γ.
MOJAVE: Monitoring of Jets in Active Galactic Nuclei with VLBA Experiments. III. Deep VLA Images at 1.4 GHz

The MOJAVE blazar sample consists of the 133 brightest, most compact radio-loud AGNs in the northern sky, and it is selected on the basis of VLBA 2 cm correlated flux density exceeding 1.5 Jy (2 Jy for declinations south of 0°) at any epoch between 1994 and 2003. Since 1994 we have been gathering VLBA data on the sample to measure superluminal jet speeds and to better understand the parsec-scale kinematics of AGN jets. We have obtained 1.4 GHz VLA A configuration data on 57 of these sources to investigate whether the extended luminosity of blazars is correlated with parsec-scale jet speed and also to determine what other parsec-scale properties are related to extended morphology, such as optical emission line strength and gamma-ray emission. We present images and measurements of the kiloparsec scale emission from the VLA data, which will be used in subsequent statistical studies of the MOJAVE sample.
Molecular Biomarkers in Multiple Sclerosis

Multiple sclerosis (MS) is an autoimmune inflammatory-neurodegenerative disease of the central nervous system (CNS) characterized by significant inter- and intra-individual different presentations. Using the clinical and imaging biomarkers is currently not able to predict the severity of disease. However, molecular biomarkers which are easily detectable come from the aspects of immunology and neurobiology due to the causal immunopathogenesis and can excellently predict other disease characteristics. Only a few molecular biomarkers have so far been routinely assessed in clinical practice as the assessment of their sensitivity, specificity, and measurement take a long time. In this review, we shed a light on the characteristics that an ideal MS biomarker should have and also the problems of introducing new biomarkers. Furthermore, clinically associated and well-established biomarkers from the blood and cerebrospinal fluid (CSF) are described which are practical for MS diagnosis and prognosis as well as for the evaluation of therapy response and complications.
Gain-of-function mutations of mau /DrAqp3a influence zebrafish pigment pattern formation through the tissue environment

: The development of the pigmentation pattern in zebrafish is a tightly regulated process that depends on both the self-organizing properties of pigment cells and extrinsic cues from other tissues. Many of the known mutations that alter the pattern act cell autonomously in pigment cells, and our knowledge about external regulators is limited. Here, we describe several dominant missense mutations in Aquaporin 3a (Aqp3a/ mau ) that lead to broken stripes and short fins in zebrafish. A loss-of-function allele, generated by CRISPR-Cas9, has no phenotypic consequences, demonstrating that Aqp3a is dispensable for normal development. Strikingly, the pigment cells from dominant mau mutants are capable of forming a wild type pattern when developing in a wild type environment, but the surrounding tissues in the mutants influence pigment cell behaviour and interfere with the patterning process. The mutated amino acid residues in the dominant alleles line the pore surface of Aqp3a and influence pore permeability These results demonstrate an important effect of the tissue environment on pigment cell behaviour and thereby on pattern formation.
Q A ] 1 7 O ct 2 00 1 ITEP-TH-57 / 01 Unitary Representations of Quantum Lorentz Group and Quantum Relativistic Toda Chain

The aim of this paper is to give a group theoretical interpretation of the three types of Bessel-Jackson functions. We consider a family of quantum Lorentz groups and a family of quantum Lobachevsky spaces. For three members of quantum Lobachevsky spaces the Casimir operators give rise to the two-body relativistic open Toda lattice Hamiltonians. Their eigen-functions are the modified Bessel-Jackson functions of three types. We construct the principal series of unitary irreducible representations of the quantum Lorentz groups. Special matrix elements in the irreducible spaces are the Bessel-Macdonald-Jackson functions. They are the wave functions of the two-body relativistic open Toda lattice. We obtain integral representations for these functions.
Contributions of Demographic Features, Medications, and Illicit Drugs to Opioid Pain Reliever Misuse and Abuse

The misuse and abuse of prescription opioids (MUPO) is influenced by both personal and environmental factors. Aggregated measures of pain reliever use, misuse, and abuse, demographic factors, use of medications, and illicit drugs, were constructed using data from the National Survey on Drug Use and Health (NSDUH 2015-2016). Weighted Least Squares (WLS) regression of pain reliever misuse and abuse (PRLMISAB) was conducted with a subset of N = 6,946 individuals who self-reported MUPO. Age, sex, marital status, and education level were negatively related to PRLMISAB, whereas use of medications and illicit drugs were positively associated with PRLMISAB. Individuals who were older, female, married, with more education were less likely to misuse and abuse opioid pain relievers than their counterparts. The effects of these demographic factors varied by age group. Use of any opioid pain relievers predicted PRLMISAB across all age groups, followed by tranquilizer use. Overall, the proportion of PRLMISAB was higher among individuals who had used heroin than those who had not; however, cocaine and amphetamines were more influential predictors of PRLMISAB than heroin. The relation between illicit drug use and PRLMISAB also varied by age group. Heroin predicted PRLMISAB between 18 to 49 years; use of amphetamines significantly predicted PRLMISAB between 12 to 35 years. Some demographic features may play a role in helping to prevent or decrease opioid misuse, and contribute to resilience in overcoming opioid abuse and addiction. 1
Expression and Functional Assessment of an Alternatively Spliced Extracellular Ca 2 (cid:1) -Sensing Receptor in Growth Plate Chondrocytes

The extracellular Ca 2 (cid:1) -sensing receptor (CaR) plays an es- sential role in mineral homeostasis. Studies to generate CaR-knockout (CaR (cid:2) / (cid:2) ) mice indicate that insertion of a neomycin cassette into exon 5 of the mouse CaR gene blocks the expression of full-length CaRs. This strategy, however, allows for the expression of alternatively spliced CaRs missing exon 5 [ Exon5( (cid:2) ) CaRs]. These experiments addressed whether growth plate chondrocytes (GPCs) from CaR (cid:2) / (cid:2) mice express Exon5( (cid:2) ) CaRs and whether these receptors activate signaling. RT-PCR and immunocytochemistry confirmed the expression of Exon5( (cid:2) ) CaR in growth plates from CaR (cid:2) / (cid:2) mice. In Chinese hamster ovary or human embryonic kidney-293 cells, recom- binant human Exon5( (cid:2) ) CaRs failed to activate phospholipase C likely due to their inability to reach the cell surface as as- sessed by intact-cell ELISA and immunocytochemistry. Human Exon5( (cid:2) ) CaRs, however, trafficked normally to the cell surface when overexpressed in wild-type or CaR (cid:2) / (cid:2) GPCs. Immunocytochemistry of growth plate sections and cultured GPCs from CaR (cid:2) / (cid:2) mice showed easily detectable cell-mem- brane expression of endogenous CaRs (presumably Exon5( (cid:2) ) CaRs),suggestingthattraffickingofthisreceptorform to the membrane can occur in GPCs. In GPCs from CaR (cid:2) / (cid:2) mice, high extracellular [Ca 2 (cid:1) ] ([Ca 2 (cid:1) ] e ) increased inositol phosphate production with a potency comparable with that of wild-type GPCs. Raising [Ca 2 (cid:1) ] e also promoted the differentiation of CaR (cid:2) / (cid:2) GPCs as indicated by changes in proteogly- can accumulation, mineral deposition, and matrix gene expression. Taken together, our data support the idea that expression of Exon5( (cid:2) ) CaRs may compensate for the loss of full-length CaRs and be responsible for sensing changes in [Ca 2 (cid:1) ] e in GPCs in CaR (cid:2) / (cid:2) mice. ( Endocrinology 146: 5294–5303, 2005) immunoblotting, and immunocytochemistry. We assessed signaling and expression properties of Exon5( (cid:2) ) CaRs in transfected Chinese hamster ovary (CHO) and human embryonic kidney (HEK)-293 cells and GPCs. Finally, we tested the ability of GPCs from CaR (cid:2) / (cid:2) mice to activate signal transduction and modulate differentiation in response to changes in [Ca 2 (cid:1) ] e and other known CaR agonists. Our findings support the idea that these alternatively spliced CaR transcripts may play a functional role in cartilage under conditions in which wt CaRs are absent.
A COMPARATIVE STUDY ON THE REDUCED CD4 COUNT AND SKIN MANIFESTATION

: Objective: The manifestations of the skin are very frequent medical aspects among the patients of HIV. The objective of this research work was to record the manifestations of the skin and their associations with the amount glycoprotein on the surface of helper T cells known as CD4 among patients of HIV in Mayo Hospital Lahore. Methodology: Skin specialist checked the abnormalities of the skin in the patients and counts of CD4 were gotten from the record of the patient. T test was in use for the analysis of the collected information. Results: In this research work, sixty-six patients were present with at least one abnormality of the skin. Infections by fungi were the most frequent reason of these diseases. There were eight most frequent types of abnormality of mucocutaneous were available. Inflammation of the gums is the most common manifestation. The average count of the CD4 cell was less in the patients found with skin diseases due to viruses and bacteria. Conclusion: The outcome of this research work showed that the complications of the skin were very common in the patients suffering with HIV. Patients with severe conditions of the skin abnormalities were available with lower amount of the CD4 cells. So, the check-ups of the skin of the patients of HIV should be carried out for the early diagnosis of the skin complications. The early discovery and the administration of the skin problems will promote the QOL (quality of life) of the patients suffering of HIV.
Electroretinogram Changes Following Sequential Panretinal Photocoagulation for Proliferative Diabetic Retinopathy

Purpose: To evaluate changes in electroretinogram (ERG) response over the course of multiple sessions of panretinal photocoagulation (PRP) in patients with proliferative diabetic retinopathy (PRP). Methods: A prospective cohort study of 11 patients with PDR who required PRP was conducted. PRP was completed over three sessions. Each patient had ﬁ ve ERGs done: baseline, 1 week after each PRP session, and 6 weeks after the last session of PRP. Dark-adapted 0.01 ERG, Dark-adapted 3 ERG, Dark-adapted 10 ERG, Light- adapted 3 ERG, and Light-adapted 30 Hz ﬂ icker ERG were done. The mean change in a- and b-wave amplitudes as well as implicit times compared to baseline was analyzed. Results: A signi ﬁ cant reduction in peak amplitudes of both a- and b-waves and delay in latencies were observed in all responses (p<0.05). The absolute amplitude reduction and delay in latency were higher for scotopic b-waves (p<0.05). The root mean square (RMS) of Dark-adapted 10.0 ERG (p<0.05) and total mean amplitude changes of a- and b-waves (p<0.001) were reduced after each laser session; however, the magnitude of change was not different between the ﬁ rst, second, or third sessions of PRP, and each session showed a similar deterioration rate of ERG parameters comparing to each other (p=0.4 for RMS and p=0.2 for total mean amplitude changes). In addition, the results indicated recovery of the amplitude and latency of ERG waves after 6 weeks from the ﬁ nal treatment (p<0.001) although not to baseline levels. Conclusion: ERG ﬁ ndings following PRP show reduced retinal function after each session which partially recovers by 6 weeks after the completion of therapy. Clinicians should be mindful of these changes when planning the treatment course for patients with PDR.
Biosurfactants in Biomedical Fields

Biosurfactants are a group of surface-active molecules produced by microorganisms. The use of biosurfactants in the medicinal field has increased during the past decade. The antibacterial, antifungal antiviral and antitumoral activities make them relevant molecules for applications in combating many diseases and as therapeutic agents [1]. In fact, numerous investigations in the field of bio surfactants are leading to the discovery and description of many interesting chemical and biological properties and potential biomedical therapeutic and prophylactic applications. In this review, the application of bio surfactants in the medicinal field is discussed.
Experience-based co-design (EBCD) with young people who offend: Innovating methodology to reach marginalised groups

The mental health needs of young people who offend have become more widely recognised and attempting to meet these needs is now a global priority for governments and health agencies. Young people who offend experience a range of complex difficulties and have significantly worse health and social outcomes than their mainstream counterparts. These problems usually persist and often increase in severity through adolescence and into later life. There is growing acceptance of the potential value of co-designing services that recognise and address problems to improve the outcomes of young people with mental health problems yet to date, this methodological approach remains relatively unexplored in forensic service provision. Experience-based co-design (EBCD) is an approach to healthcare improvement that enables staff and service users to jointly co-design services. Central to the approach is the idea that understanding the experiences of service users and the ‘touchpoints’ (e.g., critical points or moments) in their journey through a service are integral to service improvement. The aim of this study was to explore whether EBCD could be applied to facilitate recognition of, and service developments for, young people presenting in community forensic settings. Qualitative methods used in this study included: observational fieldwork in four police custody suites (n = 30 hours), in-depth interviews with staff in community forensic services (n = 13) and researcher staff (n = 7). In this paper, the challenges of applying EBCD in community forensic settings with this population were: working with and across agencies; gaining access to participants; understanding knowledge and power dimensions amongst participants and understanding the context. This paper argues that innovative approaches to discovering the touchpoints for young people who offend – a key component of the EBCD approach - through combining analyses of secondary data and direct observations in community forensic settings can facilitate engagement with these specialist services and so provide access to relevant information about a group (i.e., young people who offend) who may be unable to participate directly in the EBCD process.
Community‐dwelling older adults' acceptance of smartwatches for health and location tracking

Abstract Background Despite rapid growth in the popularity of smartwatches, evidence lacks regarding older adults’ acceptance of smartwatches. Since most wearable sensors are not designed specifically for older adults, there is a need to examine wearability and usability challenges of wearable sensing devices faced by older adults to facilitate the use of objective measurements of health and mobility. Objectives We aimed to examine older adults' perceptions of GPS‐enabled smartwatches and to identify potential barriers and facilitators of smartwatch and sensor data use. Methods As part of a larger feasibility study, we conducted a mixed‐methods study that included a descriptive content analysis of interviews and a brief usability survey with 30 participants aged 60 years and older after they had used a smartwatch for 3 days. Results Most participants perceived wearable activity trackers including smartwatches and sensor‐based data as useful for tracking health, finding activity patterns and promoting healthy behaviours. Privacy was of little concern, leading to willingness to share activity and location data with others. Participants identified barriers to usability as clumsy design, lack of aesthetic appeal, and difficulty reading the display and using the GPS tracking function. In contrast, identified facilitators of adoption included a big display, high‐tech look, self‐awareness and possible behaviour change. Conclusions Smartwatches have the potential of personalised detection of health deterioration and disability prevention, based on analysis of older adults' activities in free‐living environments. The usefulness of this technology for older adults can be significantly increased by addressing usability issues and providing instructions on challenging features. Implications for Practice To support sustained self‐monitoring behaviours through wearable sensor devices in older adults, it is critical to examine how they perceive those devices and identify factors affecting technology acceptance that can maximise adoption.
Study of impacts of education, open-access medical publishing, and internet on women’s health in China

Abstract The researchers’ aim to quantitatively study the impacts of education, health expenditure, Internet, mobile phone, and open-access articles in medical science on women’s health in China. We found that there are very strong significant negative correlations between the data of women’s mortality rates and female school enrollment (p≪0.01), whereas there are strong significant negative correlations for open-access papers in eight disciplines of medical science, individuals using the Internet, and mobile cellular subscriptions (p≪0.01). The first principal component explains 96.8%, 96.6%, and 99.6% of the variation in the mortality rate of female infants (p = 0.002 < 0.01), females under-5 (p = 0.003 < 0.01), and female adults (p = 0.002 < 0.01), respectively. There is a similar relationship between open-access medical papers and women’s health. The above results could be helpful to interdisciplinary audiences (patients, practitioners, and policymakers) to develop strategies for the effective implementation of knowledge on women’s health (how to disseminate knowledge more effectively in the whole society).
Toll‐like receptor‐1, ‐2, and ‐6 genotypes in relation to salivary human beta‐defensin‐1, ‐2, ‐3 and human neutrophilic peptide‐1

Abstract Aim To examine whether functional gene polymorphisms of toll‐like receptor (TLR)1, TLR2, and TLR6 are related to the salivary concentrations of human beta‐defensins (hBDs)‐1, ‐2, ‐3, and human neutrophilic peptide (HNP)‐1. Materials and Methods Polymorphisms of TLR1 (rs5743618), TLR2 (rs5743708), and TLR6 (rs5743810) were genotyped by PCR‐based pyrosequencing from the salivary samples of 230 adults. Salivary hBD‐1, ‐2, ‐3, and HNP‐1 concentrations were measured using enzyme‐linked immunosorbent assay. General and periodontal health examinations, including panoramic radiography, were available for all participants. Results The genotype frequencies for wild types and variant types were as follows: 66.5% and 33.5% for TLR1, 95.5% and 4.5% for TLR2, and 25.1% and 74.9% for TLR6, respectively. The TLR2 heterozygote variant group exhibited higher salivary hBD‐2 concentrations than the TLR2 wild‐type group (p = .038). On the contrary, elevated hBD‐2 concentrations were detected in the TLR6 wild‐type group compared with the TLR6 heterozygote and homozygote variant group (p = .028). The associations between TLR6 genotypes and salivary hBD‐2 concentrations remained significant after adjusting them for periodontal status, age, and smoking. Conclusion hBD‐2 concentrations in saliva are related to TLR2 and TLR6 polymorphisms, but only the TLR6 genotype seems to exhibit an independent association with the salivary hBD‐2 concentrations.
Exploring emergency physicians’ knowledge, attitudes, and behaviour towards Choosing Wisely in Taiwan

Background In 2012, the American Board of Internal Medicine Foundation launched the Choosing Wisely campaign to reduce unnecessary care. However, it is unclear how much emergency physicians in Taiwan understand about Choosing Wisely. The purpose of this study was to explore the knowledge, attitude, and behaviour of emergency physicians in Taiwan regarding Choosing Wisely and its related factors; the intention was to identify the baseline knowledge on the basis of which to promote Choosing Wisely in Taiwan. Methods This was a cross-sectional study including emergency physicians in Taiwan as research subjects who answered online questionnaires. A 42-item questionnaire was designed according to the Knowledge, Attitude, and Behaviour model (KAB). The questionnaire linkages were delivered to emergency physicians through social media (eg., Line, Facebook) and received assistance from different hospital directors. A total of 162 valid questionnaires were collected. Data analyses include t-test, analysis of variance, chi-square test, Pearson’s correlation, and multivariate linear regression model. Results The study determined that although only 38.9% of emergency physicians had heard of Choosing Wisely, the mean correct rate of knowledge score among emergency physicians was 70.1%. Attitude and the behaviour related to Choosing Wisely were positively associated, which means that the more positive the attitude towards Choosing Wisely is, the more positive the behaviour towards Choosing Wisely is. In multiple linear regression analyses, having served as a supervisor, belonging to divisions of health insurance service, and having heard of Choosing Wisely (P < 0.05) positively affect the knowledge of Choosing Wisely, but age presented a negative association. Conclusion This study found that physicians’ knowledge does not influence their attitudes and behaviours, which may be related to barriers of practicing Choosing Wisely activities. To effectively promote Choosing Wisely campaign, it is recommended to focus on the significant factors associated with emergency physicians’ perceptions regarding knowledge, attitude, and behavior of Choosing Wisely. Based on these factors, appropriate practice guidelines for Choosing Wisely can be formulated and promoted.