Miracle-dz/UniFAR-FTUs huggingface dataset:
Medical Characteristics of Foreign Language Patients in Paramedic Care

Background: In this study, medical and socio-demographic characteristics of foreign language patients in prehospital emergency medical care are analyzed and compared with non-foreign language patients. Methods: We performed retrospective chart review of rescue operations in four emergency medical service stations in Northern Germany over seven months as part of the DICTUM Rescue study (DRKS00016719). We performed descriptive analyses including test statistics and used partial correlation to adjust for patients’ sex and age. Results: Patients with limited German proficiency were served in 2.2% of all 7494 covered rescue operations. On average, these patients were two decades younger than their German speaking counterparts. There were significantly more patients with limited German proficiency with gynecological and obstetric problems, especially births, as well as psychiatric disorders, especially suicide attempts. Conclusions: Our findings suggest that the existing preventive programs for pregnant women and people at risk of suicide do not sufficiently reach patients with limited German proficiency. Additionally, giving birth and psychiatric breakdowns are exceptional and sensitive situations, both for patients and the paramedic staff, where the ability to communicate safely appears to be of enormous importance to enable safe treatment.
Human papillomavirus vaccination: coverage rate, knowledge, acceptance, and associated factors in college students in mainland China

ABSTRACT In China, there are about 131,500 new cases of human papillomavirus (HPV) infection every year. However, studies focused on the related cognitions in the general college-going population, who belong to an at-risk age group and are of childbearing age, are relatively limited. Thus, this cross-sectional online survey study, conducted from December 2018 to March 2019, sought to investigate HPV vaccination rates, knowledge, acceptance, and associated factors in this population. Descriptive analysis and ordinal logistic regression analysis were conducted to analyze the factors associated with HPV vaccination intention. A total of 1,029 questionnaires were collected, of which 1,022 were valid (males: 267, females: 755). As per the results, only 3.1% of the sample had been vaccinated against HPV. The overall levels of knowledge about HPV and its vaccination were low. Male students’ knowledge about HPV types, infection symptoms, vaccination cycles, and preventable diseases was significantly lower than that of female students. As for acceptance, only 36.9% of females and 24.8% of males indicated that they would choose to undergo HPV vaccination. Chinese college students’ knowledge of HPV and its vaccination is limited. More than half of the sample was unsure about undergoing HPV vaccination, with concerns about safety and effectiveness serving as the main barriers. Measures such as strengthening health education, improving vaccination safety and effectiveness, and reducing vaccine prices should be taken to promote HPV vaccination among Chinese college students.
An act of terror and an act of hate: national elite and populace newspaper framing of pulse nightclub shooting

ABSTRACT The Pulse nightclub mass shooting is a defining event for the LGBTQ and Latinx communities. It signified that much remains to be done to achieve true equality and equitable treatment over and above the symbolic mentions of it in law and public policy. The news media is an important mechanism for communication of meaning following tragic and painful events such as the Pulse shooting. This study examined how the Pulse nightclub shooting that occurred on 12 June 2016, was covered by influential national newspapers in the United States, The New York Times, The Washington Post, and USA Today, to determine how the event was framed, what types of sources were relied upon, and what types of social and legal solutions were emphasized. The unit of analysis was direct and indirect quotes in each news article. Content analysis revealed that the dominant framing of the attack was that of a terrorist act committed by a pathological, ideologically motivated offender. The most common control mechanism discussed were soft measures, particularly gun control. Little attention was given to the victims or the anti-LGBTQ nature of the shooting.
The bioactivity of titanium-cuttlefish bone-derived hydroxyapatite composites sintered at low temperature

The most limiting features of titanium as a bone substituent are lack of bioactivity and high Young's modulus. We have prepared titanium-hydroxyapatite (Ti-HAp) composites using titanium hydride as sintering agent to provide titanium sintering at lower temperature and preserve the stability of apatite phase. After low temperature sintering, no hydroxyapatite decomposition was detected. Pure titanium samples sintered in the presence of hydride showed smooth surface indicating good densification at 800°C. Higher HAp content resulted in decreased density and higher porosity due to the formation of micro- and macro-pores caused by the integration of HAp particles into titanium matrix and titanium hydride decomposition. However, Vickers microhardness test showed increased hardness for Ti-HAp composite with 10% of HAp regarding pure Ti. The bioactivity of Ti-HAp composites evaluated in simulated body fluid significantly improved with HAp content. The presence of HAp has lowered the cytotoxic effect of Ti-based composites on Hek293 cells.
Spatial economic aspects of climate change

ABSTRACT The objective in this special issue is twofold. First, it emphasizes the importance of comprehending that, the global impacts of climate change notwithstanding, there are salient region-specific impacts that vary across space. Second, given this observation, it is shown how rigorous modelling of the connections between climate change and (1) land-use changes, (2) forestry, (3) infrastructure and (4) local labour markets sheds light on a variety of climate change-induced spatial economic effects. Following this introductory paper are seven additional papers in the issue. Each discusses a particular research question at the interface of what would be called ‘climate change and space’.
Antibiotic susceptibility patterns of Uropathogenic Escherichia coli among patients with urinary tract infections in a tertiary care hospital in Maiduguri, North Eastern, Nigeria

Escherichia coli (E. coli) has been identified as the most common uropathogenic bacterial pathogen with increasing resistance to antibiotics. Aetiology of urinary tract infections (UTI) and their antibiotic sensitivity patterns vary from time to time and across different areas. In Nigeria, studies on the prevalence and antimicrobial susceptibility patterns of clinical isolates from urinary tract infections are inadequate. Employing standardised microbiological methods, this study assessed the prevalence and antimicrobial susceptibility patterns of E. coli isolates from UTI in University of Maiduguri Teaching Hospital (a tertiary health care institution) in North Eastern, Nigeria. Uropathogenic E. coli (UPEC) accounted for 150 (62.50%) of 240 urine isolates. Lowest susceptibility was for Ampicillin 54 (36.0%), Ciprofloxacin 69 (46.0%) and Norfloxacin 72 (48.0%). More than 50% were susceptible to Levofloxacin and Streptomycin 71 (54.0%) each, Cefuroxime and Co-trimoxazole 78 (52.0%) each, while highest susceptibility was for Nitrofurantoin 117 (78.0%), Chloramphenicol 105 (70.0%) and Gentamicin 96 (64.0%). The isolates were commonly resistant to 9 (24.24%) of the ten (MARI of 0.9) classes of antimicrobial agents used in this study and all the isolates were multidrug-resistant. There is a need for proper surveillance and development of hospital specific antibiograms to inform appropriate empiric therapy of urinary tract infections.
Lead ammunition residues in the meat of hunted woodcock: a potential health risk to consumers

Abstract Wild meat often retains metallic particles originating from the ammunition fired by hunters. Since ammunition are traditionally lead (Pb)-based, the consumption of game meat may entail the ingestion of Pb embedded in tissues. To assess the related risks to human health, information is needed on the number, dimension and spatial distribution of Pb particles embedded in popular quarry species. In this study, we focused on the Eurasian woodcock (Scolopax rusticola), a medium-sized bird intensively hunted across its range. We X-rayed 59 carcasses of woodcock shot by Italian hunters in Ukraine. To check the ammunition types and evaluate the mean weight of the embedded gunshot, we excised a sample of 62 whole pellets from 20 birds. Ammunition residues were found in 57 of the 59 woodcock (96.6%). Radiographs revealed 215 whole pellets and 125 fragmentation centres in 51 (mean = 3.64) and in 48 birds (mean = 2.14), respectively. Most fragmentation centres (75.7%) contained tiny particles (<1 mm). The overall estimated Pb load ranged from 45 to 52 mg/100 g wet weight, most of which (84.6%) in edible parts. The number of embedded pellets per unit of body mass (1.21/100 g of body weight) was higher in comparison with other bird species and also with woodcock shot in the UK, presumably owing to the hunting methods adopted by Italian hunters. The quantity and characteristics of ammunition residues we found suggest that game meat consumers are exposed to a relevant Pb assumption.
Effects of a Thermosensitive Antiadhesive Agent on Single-Row Arthroscopic Rotator Cuff Repair

Background: Postoperative stiffness after rotator cuff repair is a common complication that can lead to poor outcomes and patient discomfort. The application of an antiadhesive agent at the time of repair recently became an option for clinicians, but little information is available on its effects. Purpose: To evaluate and compare retear rates, the incidence of postoperative stiffness, and the clinical outcomes of patients who underwent cuff repair with or without the application of an antiadhesive agent. Study Design: Cohort study; Level of evidence, 3. Methods: Among 296 patients who underwent arthroscopic rotator cuff repair surgery, we compared the outcomes of those injected with a thermosensitive gel antiadhesive agent into the subacromial space (112 cases) versus noninjected controls (184 cases). Retear rates in the 2 groups were determined by magnetic resonance imaging at 1 year after surgery. Shoulder joint range of motion and functional scores were evaluated serially. Results: The rate of retear was significantly lower in the injection group (20/112 cases; 17.9%) than the control group (53/184 cases; 28.8%) (P = .034). Postoperative stiffness was not significantly different between the 2 groups (P = .710). Among the data regarding range of motion, only forward flexion at 6 months after surgery showed superior results in the injection group. Functional scores showed conflicting results: The control group had better visual analog scale scores for pain (injection vs control: 2.17 vs 1.68 at 6 months; 1.82 vs 1.28 at 12 months), American Shoulder and Elbow Surgeons scores (79.89 vs 89.64 at 12 months), and simple shoulder test scores (8.70 vs 10.06 at 12 months), whereas the injection group had better Constant-Murley scores (injection vs control: 59.49 vs 55.60 at 3 months; 77.35 vs 71.98 at 6 months; 87.28 vs 81.56 at 12 months). Conclusion: The tendon healing rate was significantly higher in the group receiving an antiadhesive agent than in the control group. No intergroup difference was seen in the occurrence of postoperative stiffness. However, the pain-related functional score showed inferior results in the injection group at 12 months. The biological action of antiadhesive agents in rotator cuff repair should be further evaluated.
Endodontic treatment of traumatized teeth with chronic periapical lesions using antibiotic paste and mineral trioxide aggregate obturation - a preliminary study

Introduction/Objective. The purpose of this study was to assess effectiveness of endodontic root canal procedures in traumatized permanent teeth with necrotic pulps and chronic periapical lesions after definitive obturation with mineral trioxide aggregate (MTA) products. Adobe Photoshop CS (San Jose, CA, USA) image-analysis software was used for healing assessment. Methods. Twenty-seven traumatized single-rooted permanent teeth diagnosed with necrotic pulps and chronic periapical lesions were treated with non-surgical procedure using a tri-antibiotic paste and calcium hydroxide as intra-canal medication. Definitive obturation was performed with ProRoot MTA (Dentsply Tulsa Dental Specialties, Tulsa, OK, USA) or MTA+ Cerkamed (Cerkamed, Stalowa Wola, Poland). Control follow-ups were done three, six, 12, and 24 months following the completion of treatment. Results. The positive clinical outcome was recorded in 24 (88.9%) cases, while radiographic success was present in 26 (96.3%) cases. A statistically significant decrease in the sizes of periapical lesions was consistently observed at follow-up periods (p < 0.001). There was no statistically significant difference between the two tested MTA materials (p > 0.05). Conclusion. The MTA products were effective for the root canal obturation and appeared to contribute to the significant reduction or complete regression of periapical lesions in teeth treated. The presented procedure may be proposed for everyday clinical practice.
Effects of Low Temperature Stress on the Content of Malondialdehyde in Rape Seedlings

To indentify the cold resistance of different cultured rape types,3 rape cultivars(Brassica napus L,Brassica juncea L.,and Brassica campestris L.) were selected and the change of malondialdehyde(MAD) content in leaves of them under different low temperature stresses was studied using the method of temperature-controlling by artificial climatic box.The results showed that the MAD contents dramatically increased with the decrease of the temperature and with the extension of the stress time.The range and regular pattern of the MAD content change in different cultivars or different treatment conditions were different.The cold resistance of Brassica campestris L.was the strongest among the three cultivations.
Informal social protection actors: A focus on women self-help groups in Kenya

For most countries in sub-Saharan Africa, social protection is provided by formal and informal actors. Focusing on women self-help groups as informal social protection actors, this qualitative study examines their nature, activities and functions and how they provide informal social protection. Data on self-help groups were collected from 25 women through in-depth individual interviews and focus group discussions. The findings show that these groups provide crucial safety nets by smoothing incomes and consumption, and providing social assistance and insurance. However, social protection provided informally is exclusionary and limited. The implications of these findings are discussed.
A YAP/FOXM1 axis mediates EMT-associated EGFR inhibitor resistance and increased expression of spindle assembly checkpoint components

YAP and FOXM1 are mediators of EGFR inhibitor resistance, and spindle proteins are therapeutic targets for this multidrug-resistant phenotype. Path of least resistance Drugs that inhibit the epidermal growth factor (EGFR) are used in a number of cancer types, including lung cancer, but the evolution of resistance to treatment remains a problem. In some cases, resistance emerges through mutations in EGFR itself, but it can also develop through alternate mechanisms, which can be more difficult to overcome. Nilsson et al. focused on one such mechanism of resistance, associated with a change in the phenotype of cancer cells called epithelial-to-mesenchymal transition. This change was associated with resistance to multiple cancer drugs, but the authors identified several therapeutic vulnerabilities in the multidrug-resistant cells. Acquired resistance to tyrosine kinase inhibitors (TKIs) of epidermal growth factor receptor (EGFR) remains a clinical challenge. Especially challenging are cases in which resistance emerges through EGFR-independent mechanisms, such as through pathways that promote epithelial-to-mesenchymal transition (EMT). Through an integrated transcriptomic, proteomic, and drug screening approach, we identified activation of the yes-associated protein (YAP) and forkhead box protein M1 (FOXM1) axis as a driver of EMT-associated EGFR TKI resistance. EGFR inhibitor resistance was associated with broad multidrug resistance that extended across multiple chemotherapeutic and targeted agents, consistent with the difficulty of effectively treating resistant disease. EGFR TKI–resistant cells displayed increased abundance of spindle assembly checkpoint (SAC) proteins, including polo-like kinase 1 (PLK1), Aurora kinases, survivin, and kinesin spindle protein (KSP). Moreover, EGFR TKI–resistant cells exhibited vulnerability to SAC inhibitors. Increased activation of the YAP/FOXM1 axis mediated an increase in the abundance of SAC components in resistant cells. The clinical relevance of these finding was indicated by evaluation of specimens from patients with EGFR mutant lung cancer, which showed that high FOXM1 expression correlated with expression of genes encoding SAC proteins and was associated with a worse clinical outcome. These data revealed the YAP/FOXM1 axis as a central regulator of EMT-associated EGFR TKI resistance and that this pathway, along with SAC components, are therapeutic vulnerabilities for targeting this multidrug-resistant phenotype.
COVID-19 Pandemic Challenges and Lessons Learned by Pharmacy Educators Around the Globe

The coronavirus identified in 2019 (COVID-19) has affected peoples’ lives worldwide. This pandemic forced both pharmacy faculty members and students to adapt to a new teaching and learning environment not only in the United States but around the globe. Pharmacy educators faced challenges and opportunities to convert classroom learning and experiences, as well as student assessments, to a remote or online format. The unique approaches taken to overcome difficulties in various countries showed pharmacy faculty members’ resilience in the face of adversity and their determination to continue providing education to students. The pandemic also shed light on areas needing improvement for pharmacy educators to work on in the future.
Prospective Single-Blinded Randomized Controlled Trial Comparing Pericapsular Injection Versus Lumbar Plexus Peripheral Nerve Block for Hip Arthroscopy

Background: Hip arthroscopy has become the standard for the operative treatment of symptomatic femoroacetabular impingement. Given the high levels of postoperative pain associated with hip arthroscopy, optimal analgesia is critical to ensure patient comfort and safety after discharge. Purpose/Hypothesis: Our purpose was to perform a single-blinded randomized controlled trial comparing the use of pericapsular injection versus lumbar plexus blockade for postoperative pain control after arthroscopic surgery on the hip. We hypothesized that pericapsular injection would provide equivalent pain relief to that of lumbar plexus blockade while minimizing adverse effects and alleviating the dependence on a qualified individual to administer. Study Design: Randomized controlled trial; Level of evidence, 1. Methods: A total of 64 consecutive patients undergoing hip arthroscopy were prospectively assessed over a 6-month period between 2017 and 2018. Patients were randomly allocated to 1 of 2 groups: 32 patients received a lumbar plexus blockade by a single anesthesiologist, while 32 patients received a pericapsular injection of 30 mL of ropivacaine and 12 mg of morphine. Postoperative pain in the postanesthesia care unit (PACU) as measured using the numeric rating scale, time to discharge, PACU morphine equivalents, and adverse effects were collected by PACU staff. Postoperative day 1 and 2 narcotic use was obtained through a telephone call with the patient on postoperative day 3. Results: We found no statistically significant difference in PACU pain scores at all time points, although there was a trend toward lower pain for patients receiving a pericapsular injection. PACU and short-term narcotic demand did not vary across the 2 arms. Time to discharge from the PACU did not differ. There were no major adverse events reported for either intervention. Conclusion: Pericapsular injection provides equivalent analgesia when compared with lumbar plexus blockade. It is a safe intervention that allows for efficient postoperative analgesia for patients undergoing hip arthroscopy. Registration: ClinicalTrials.gov ID: NCT03244631.
Nutritional Studies on Mango—Tentative Leaf Analysis Standards*

Sand culture studies were conducted on mango with the object of producing characteristic foliar deficiency symptoms and establishing critical levels for various macro-elements. Deficiency symptoms were developed for nitrogen, phosphorus, potassium, calcium magnesium and sulphur by growing young mango seedlings in nutrient media containing all the essential elements in satisfactory concentrations except the elements of which deficiency symptoms were to be induced. Leaves were sampled for analysis just at the time when deficiency symptoms first became noticeable and also when they had fully developed. Symptoms of deficiency for various macro-elements as exhibited by leaves of Dashehari mango seedlings have been described. Based on the results of foliar analysis, tentative, lower critical values for various macro-nutrients have been suggested.