Miracle-dz/UniFAR-FTUs huggingface dataset:
Cognitive performance in older people after mild traumatic brain injury: Trauma effects and other risk factors

Abstract Objective: Cognitive symptoms are common in the initial weeks after mTBI, but recovery is generally expected within three months. However, there is limited information about recovery specifically in older age cohorts. Therefore, this study investigated cognitive outcome three months after mTBI in older adults (≥ 65 years) compared to trauma and community age-matched controls and explored risk factors for outcome after traumatic injury. Methods: Older mTBI patients (n = 40) and older adults with mild traumatic injury but without head injury (n = 66) were compared to a noninjured community control group (n = 47). Cognitive assessment included neuropsychological and computerized tests. Group differences were compared on individual tasks and overall cognitive performances using composite scores. Regression analyses identified predictors of outcome for trauma patients and moderator analyses explored possible interactions of mTBI severity with age and cognition. Results: As well as lower performances in processing speed and memory, both trauma groups had significantly lower performance on composite neuropsychological (d = .557 and .670) and computerized tasks (d = .783 and .824) compared to noninjured controls. Age, education, and history of depression were direct predictors of cognitive performance after mild traumatic injury (with or without head injury). Further moderation analysis demonstrated that mTBI severity (Glasgow Coma Scale < 15) moderated the impact of older age on computerized assessment (β = -.138). Conclusions: Three months after mild trauma (regardless of head injury), older people demonstrate lower cognition compared to noninjured peers. However, severity of mTBI (Glasgow Coma Scale < 15) can interact with older age to predict poorer cognitive outcomes.
Effect of remdesivir on mortality rate and clinical status of COVID-19 patients: a systematic review with meta-analysis

Abstract Remdesivir (RDV) is a broad-spectrum antiviral drug, now approved by Regulatory Agencies for COVID-19 treatment. RDV is associated with improvements in clinical outcomes, but no conclusive studies have shown an effect in reducing mortality. This study aimed to carry out a systematic review with meta-analysis to investigate whether RDV can significantly modify the outcome of COVID-19 patients evaluating its effects on mortality, length of stay, time to clinical improvement and need for oxygen supplementation. No significant improvement in terms of survival in patients treated with standard therapy (ST)+RDV as compared to ST alone (P = 0.24) was found. The duration of oxygen support was significantly lower in patients treated with ST + RDV compared with ST alone (P = 0.03). Further investigations should be planned to assess the real impact of RDV in the management of COVID-19 patients.
Child Cognitive Flexibility and Maternal Control: A First Step toward Untangling Genetic and Environmental Contributions

Abstract Executive functions (EF) play an essential role in many spheres of child development. Therefore, it is crucial to get a better understanding of their etiology. Using a genetic design that involved 934 twins (400 monozygotic), this study examined the etiology of cognitive flexibility, a component of EF, at 5 years of age and its phenotypic and etiological associations with maternal control. Cognitive flexibility was measured in a laboratory setting at 5 years of age using a well-known EF-task, i.e. the Dimensional Change Card Sort (DCCS). Maternal control was measured using a self-report questionnaire. The univariate genetic model demonstrated that environmental factors mainly explained individual differences in preschoolers’ performance on the DCCS task. A bivariate genetic model demonstrated that non-shared environmental mechanisms mainly explained the association (r = .−13) between maternal control and children’s performance on the DCCS task. This study represents a preliminary step toward a better understanding of the genetic and environmental contributions underlying the relation between parenting behaviors and children’s EF.
Serum leptin correlates in fertile and idiopathic infertile Yemeni males: a comparative cross-sectional study

Abstract This comparative cross-sectional study aimed to evaluate the relationship between serum leptin and testosterone, FSH, LH, PRL and semen quality in fertile and idiopathic infertile Yemeni men. A total of 30 infertile males with unknown causes and 30 age-matched healthy fertile males were enrolled in this study. The body mass index (BMI) and waist circumference (WC) were measured. Semen samples were analyzed according to the WHO manual for semen analysis. Serum samples were tested for hormones. Subjects were then divided into subgroups and compared based on their main seminal findings. The WC, serum leptin, PRL, FSH and LH levels were significantly higher (p < 0.05) in the infertile subjects than in the fertile group. Serum leptin demonstrated a significant positive correlation (p < 0.01) with body weight, BMI and WC in fertile males and a significant negative correlation (p < 0.01) with testosterone in fertile and infertile males. Similarly, a significant positive correlation was found between serum leptin and FSH (p < 0.01) and LH (p < 0.05) levels in the infertile subjects. The findings showed that non-obstructive azoospermic (NOA) patients have significant (p < 0.05) high levels of serum leptin, FSH, and LH. These findings may support the possibility of a direct peripheral negative effect of leptin on testicular steroidogenesis independent of the suggested indirect effect, and it could directly impact spermatogenesis without inhibiting testosterone production. This effect was accompanied by increasing serum PRL levels. Furthermore, serum leptin and gonadotropins were found to be increased in the idiopathic NOA group. The present study provided valuable insights into the fertile and idiopathic infertile Yemeni males and could establish an important foundation for future andrological-related studies such as investigating the relationship between leptin and other hormones; and infertility-related genetic and epigenetic factors.
Horn conditions for quiver subrepresentations and the moment map

We give inductive conditions that characterize the Schubert positions of subrepresentations of a general quiver representation. Our results generalize Belkale's criterion for the intersection of Schubert varieties in Grassmannians and refine Schofield's characterization of the dimension vectors of general subrepresentations. This implies Horn type inequalities for the moment cone associated to the linear representation of the group $G=\prod_x \operatorname{GL}(n_x)$ associated to a quiver and a dimension vector $\mathbf n=(n_x)$.
PINCH: An Adversarial Extraction Attack Framework for Deep Learning Models

Adversarial extraction attacks constitute an insidious threat against Deep Learning (DL) models in-which an adversary aims to steal the architecture, parameters, and hyper-parameters of a targeted DL model. Existing extraction attack literature have observed varying levels of attack success for different DL models and datasets, yet the underlying cause(s) behind their susceptibility often remain unclear, and would help facilitate creating secure DL systems. In this paper we present PINCH: an efficient and automated extraction attack framework capable of designing, deploying, and analyzing extraction attack scenarios across heterogeneous hardware platforms. Using PINCH, we perform extensive experimental evaluation of extraction attacks against 21 model architectures to explore new extraction attack scenarios and further attack staging. Our findings show (1) key extraction characteristics whereby particular model configurations exhibit strong resilience against specific attacks, (2) even partial extraction success enables further staging for other adversarial attacks, and (3) equivalent stolen models uncover differences in expressive power, yet exhibit similar captured knowledge.
Generalized Burniat type surfaces and Bagnera-de Franchis varieties

In this article we construct three new families of surfaces of general type with p_g = q = 0,K^2 = 6, and seven new families of surfaces of general type with p_g = q = 1, K^2 = 6, realizing 10 new fundamental groups. We also show that these families correspond to pairwise distinct irreducible connected components of the Gieseker moduli space of surfaces of general type. We achieve this using two different main ingredients. First we introduce a new class of surfaces, called generalized Burniat type surfaces, and we completely classify them (and the connected com- ponents of the moduli space containing them). Second, we introduce the notion of Bagnera-de Franchis varieties: these are the free quotients of an Abelian variety by a cyclic group (not consisting only of translations). For these we develop some basic results.
Quantum algorithm for ground state energy estimation using circuit depth with exponentially improved dependence on precision

A milestone in the field of quantum computing will be solving problems in quantum chemistry and materials faster than state-of-the-art classical methods. The current understanding is that achieving quantum advantage in this area will require some degree of fault tolerance. While hardware is improving towards this milestone, optimizing quantum algorithms also brings it closer to the present. Existing methods for ground state energy estimation are costly in that they require a number of gates per circuit that grows exponentially with the desired number of bits in precision. We reduce this cost exponentially, by developing a ground state energy estimation algorithm for which this cost grows linearly in the number of bits of precision. Relative to recent resource estimates of ground state energy estimation for the industrially-relevant molecules of ethylene-carbonate and PF6−, the estimated gate count and circuit depth is reduced by a factor of 43 and 78, respectively. Furthermore, the algorithm can use additional circuit depth to reduce the total runtime. These features make our algorithm a promising candidate for realizing quantum advantage in the era of early fault-tolerant quantum computing.
Parameter-Efficient Finetuning for Robust Continual Multilingual Learning

We introduce and study the problem of Continual Multilingual Learning (CML) where a previously trained multilingual model is periodically updated using new data arriving in stages. If the new data is present only in a subset of languages, we find that the resulting model shows improved performance only on the languages included in the latest update (and a few closely related languages) while its performance on all the remaining languages degrade significantly. We address this challenge by proposing LAFT-URIEL, a parameter-efficient finetuning strategy which aims to increase the number of languages on which the model improves after an update, while reducing the magnitude of loss in performance for the remaining languages. LAFT-URIEL uses linguistic knowledge to balance overfitting and knowledge sharing across languages, allowing for an additional 25% of task languages to see an improvement in performance after an update, while also reducing the average magnitude of losses on the remaining languages by 78% relative.
Prevalence of vulvovaginal candidiasis among pregnant women in Africa: A systematic review and meta-analysis.

INTRODUCTION Vulvovaginal candidiasis (VVC) is a yeast infection of the vulva, which is caused by Candida species and affects women worldwide. Pregnant women are more vulnerable to VVC due to certain risks. Moreover, their offspring are also exposed to the risk of preterm birth. In this context, ascertaining the burden of VVC is of paramount importance and this meta-analysis was conducted to estimate the occurrence of VVC among pregnant women in Africa. METHODOLOGY Database search was carried out through PubMed, Scopus, Science-Direct, and Google Scholar from the date of inception until December 2020. All the studies on the prevalence of VVC among African pregnant women were included in the analysis. The pooled prevalence was estimated based on the Random-effect model DerSimonian-Laird approach with Freeman- Tukey double arcsine transformed proportion. Heterogeneity was assessed using I2 test and subsequently explored using subgroup and meta-regression analysis. RESULTS A total of Sixteen records having a sample size 4,185 were included in this study. The overall prevalence of VVC was pooled at 29.2% (CI 95%: 23.4 - 33.0). Subgroup analysis revealed a higher prevalence in Eastern Africa, followed by Western Africa and North Africa (35%, 28%, and 15% respectively). Moderator analysis indicated that the studies that used advanced methods of detection had a higher prevalence (p = 0.048). In addition, the large sample size was associated with higher prevalence (p ≤ 0.001). No other moderators were found to be statistically significant. CONCLUSIONS The overall prevalence of VVC among African pregnant women is comparable to other studies worldwide. However, appropriate identification techniques and larger sample size could likely be associated with an increased prevalence. Our findings necessitate the need for further investigations to determine the geographical distribution of VVC across African regions.
Barriers to accessing pre-exposure prophylaxis among women experiencing intimate partner violence in the United States: a systematic literature review

ABSTRACT Women experiencing intimate partner violence (IPV) are at increased risk of human immunodeficiency virus (HIV) infection but have limited uptake of pre-exposure prophylaxis (PrEP). We systematically reviewed the existing evidence for the association between IPV and PrEP use, and barriers to accessing PrEP among women with a history of IPV in the United States. A keyword search of PubMed, CINAHL, ScienceDirect, and Web of Science for relevant articles within the United States from 2012 to 2022 yielded 133 articles, of which 15 were ultimately included in the analysis. A qualitative synthesis of evidence suggests that the association between IPV and PrEP awareness, PrEP acceptability, PrEP use, and HIV risk perception was contingent on the mediating or moderating effects of women’s relationship status, social network characteristics, and the timing and types of IPV. Controlling partners’ reactions and a lack of independent decision-making in the abusive relationship were salient barriers. The methodological quality of qualitative studies was high; however, there were important risks of bias among quantitative and mixed-method studies. Additional studies are needed to understand barriers to PrEP use among women with IPV in more diverse settings and to provide rigorous evidence for developing targeted HIV prevention strategies for them.
Susceptibility of wild turkeys (Meleagris gallopavo) to experimental West Nile virus infection

ABSTRACT Since the introduction of West Nile virus (WNV) to North America in 1999, WNV is estimated to have contributed to population-level declines in numerous avian species. However, the potential impacts of this virus on many free-ranging upland game bird species, including the wild turkey (Meleagris gallopavo), which is undergoing regional population declines, remain unknown. Herein, two age groups (∼5 to 6 weeks and ∼15 to 16 weeks post-hatch) of juvenile wild turkeys were subcutaneously inoculated with WNV, sampled daily from 1 to 7 days post-inoculation (dpi), and euthanized on 14 dpi. No clinical signs and minimal gross lesions were attributable to WNV infection. Peak viraemia titres were similar between age groups (<101.7 to 104.6 plaque-forming units [PFU]/ml), but the duration of viraemia was longer in the old group (3–4 days) than in the young group (0–3 days). Intermittent oral and/or cloacal viral shedding from 2 to 7 dpi was detected in both age groups. No infectious virus was detected in the heart, brain, kidney, skeletal muscle, spleen, and feathers from WNV-inoculated turkeys euthanized on 14 dpi. All WNV-inoculated birds seroconverted by 14 dpi, as well as two co-housed sham-inoculated birds. The most consistent microscopic lesions among all WNV-inoculated birds were mild lymphoplasmacytic myocarditis and encephalitis. Minimal immunohistochemical labelling was detected in tissues in addition to scant macrophages within the blood, spleen, and bone marrow. These data suggest WNV is unlikely to pose a significant risk to wild turkey populations, although the possibility remains that WNV may indirectly decrease fitness or predispose wild turkeys to other health stressors. RESEARCH HIGHLIGHTS Clinical disease was not observed in wild turkeys experimentally infected with WNV. Pathology attributed to WNV was mild and included brain and heart inflammation. Viraemias suggest WNV-infected wild turkeys do not play a role in WNV transmission. No age-associated differences in WNV clinical disease or pathology were observed.
A Better Treatment for Moderate to Severe Hallux Valgus: Scarf + Akin Osteotomy Combined with Lateral Soft Tissue Release in a Single Medial Incision

Traditional lateral soft tissue release (LSTR) was conducted by an additional dorsal first web incision, as the malformed thick scar and neuritis were common after surgery. A new method of lateral soft tissue release in a single medial incision via dorsal flap over the first metatarsal (LSTR‐SMI‐DFFM) should be recommended. The objective is to investigate the clinical effectiveness and safety of scarf + Akin osteotomy (SAO) combined with lateral soft tissue release in a single medial incision via dorsal flap over the first metatarsal (LSTR‐SMI‐DFFM) for moderate to severe hallux valgus.
Tropomyosin 2 exerts anti-tumor effects in lung adenocarcinoma and is a novel prognostic biomarker.

BACKGROUND Tropomyosin 2 (TPM2), a member of the actin filament binding protein family, plays distinct roles in the progression of different cancer types. Until now, there has been no study reporting TPM2 expression nor its function in lung adenocarcinoma (LUAD). METHODS In the present study, we examined the expression profile of TPM2 by immunohistochemistry (IHC). The clinical significance of TPM2 was assessed by univariate and multivariate analyses. Function of TPM2 in LUAD was evaluated by knockdown and overexpression strategies in three LUAD cell lines, followed by proliferation and invasion assays. Xenografts were conducted in nude mice to further validate the tumor-related role of TPM2. RESULTS Our results showed that TPM2 was downregulated in LUAD specimens and the low expression of TPM2 was associated with poor outcomes of LUAD patients. Overexpressing TPM2 inhibited cell proliferation and invasion of LUAD cell lines, while silencing TPM2 exerted the opposite effects. The effects of TPM2 in LUAD were further confirmed by xenograft assays. CONCLUSIONS Our results indicated that TPM2 exerted an anti-oncogenic role in LUAD via inhibiting tumor progression, thus providing a novel direction for the prognostic prediction and disease treatment.
CAR-T Cell Therapy for Solid Tumors: Are we Still That Far? a Systematic Review of Literature

Abstract This systematic review aims to assess all the prospective studies published to date on the efficacy of CAR-T cell therapy in solid tumors. Databases searched were PubMed and Google Scholar from inception through May 1st 2021. Search query was (Chimeric antigen receptor) or (CAR-T) or (T-CAR). Twenty-nine prospective studies (265 patients) were included. Most published clinical trials are phase I. Clinical benefit was 100% in epithelial ovarian cancer, 70–82% in gastrointestinal tumors, 79% in mesothelioma, 63% in small-cell lung cancer, 24–67% in sarcoma, 50–62% in prostate cancer, and 45–50% in central nervous system tumors. No serious CAR-T cell specific serious toxicities were noted.
Analgesic Electrical Stimulation Combined with Wrist-ankle Acupuncture Reduces the Cortical Response to Pain in Patients with Myofasciitis: A Randomized Clinical Trial.

OBJECTIVE Transcutaneous electrical nerve stimulation (TENS) based on wrist-ankle acupuncture has been shown to relieve pain levels in patients with myofascial pain syndrome (MPS). However, its efficacy is highly subjective. The purpose of this study was to evaluate the feasibility and effectiveness of TENS based on wrist-ankle acupuncture for pain management in patients with MPS from the perspective of cerebral cortex hemodynamics. DESIGN, SETTING, PARTICIPANTS AND INTERVENTIONS We designed a double-blind, randomized, controlled clinical trial. Thirty-one male patients with MPS were randomly assigned to two parallel groups. The experimental group (n = 16) received TENS based on wrist-ankle acupuncture for analgesic treatment, while the control group (n = 15) did not. The pain was induced by mechanically pressurized at acupoint Jianjing. The multichannel functional near-infrared spectroscopy (fNIRS) equipment was utilized for measuring oxyhemoglobin (HbO) levels in the cerebral cortex during the tasks. RESULTS After the intervention, visual analog scale (VAS), the activation degree and activation area of pain perception cortices were significantly reduced in the experimental group compared to the baseline values (P<0.05). Particularly, Frontopolar Area (FPA), and Dorsolateral Prefrontal Cortex (DLPFC) are highly involved in the pain process and pain modulation. CONCLUSION Compared to no intervention, TENS based on wrist-ankle acupuncture can be effective in relieving pain in patients with MPS in terms of cerebral cortical hemodynamics. However, further studies are necessary to quantify the analgesic effect in terms of cerebral hemodynamics and brain activation. TRIAL REGISTRATION The study was registered in the Chinese Trial Registry (No. ChiCTR2200056394).
A Conventional Physics Explanation for the Anomalous Acceleration of Pioneer 10/11

Anderson, et al., find the measured trajectories of Pioneer 10 and 11 spacecraft deviate from the trajectories computed from known forces acting on them. This unmodelled acceleration can be accounted for by non-isotropic radiation of spacecraft heat. Various forms of non-isotropic radiation were proposed by Katz, Murphy, and Scheffer, but Anderson, et al. felt that none of these could explain the observed effect. This paper calculates the known effects in more detail and considers new sources of radiation, all based on spacecraft construction. These effects are then modelled over the duration of the experiment. The model provides a reasonable fit to the acceleration from its appearance at a heliocentric distance of 5 AU to the last measurement at 71 AU, but overpredicts by 9% the decrease in acceleration between intervals I and III of the Pioneer 10 observations. (For comparison, the two different measurements of the effect (SIGMA and CHASMP) themselves differ by 4% in interval III. ) In any case, by accounting for the bulk of the acceleration, the proposed mechanism makes it much more likely that the entire effect can be explained without the need for new physics.
Earth Soundings Analysis: Processing Versus Inversion

Convolution and spectra Discrete fourier transform Z-plane, causality and feedback Univariate problems Conjugate operators Model fitting by least squares Time-series analysis Missing-data restoration Hyperbola tricks Spectrum and phase Resolution and random signals Entropy and Jensen inequality A: RATional FORtran==Ratfor B: Seplib and SEP software C: Notation D: Interactive, 1-D, seismology program ed 1D E: The Zplane program