Miracle-dz/UniFAR-FTUs huggingface dataset:
Targeting Neutrophils for Promoting the Resolution of Inflammation

Acute inflammation is a localized and self-limited innate host-defense mechanism against invading pathogens and tissue injury. Neutrophils, the most abundant immune cells in humans, play pivotal roles in host defense by eradicating invading pathogens and debris. Ideally, elimination of the offending insult prompts repair and return to homeostasis. However, the neutrophils` powerful weaponry to combat microbes can also cause tissue damage and neutrophil-driven inflammation is a unifying mechanism for many diseases. For timely resolution of inflammation, in addition to stopping neutrophil recruitment, emigrated neutrophils need to be disarmed and removed from the affected site. Accumulating evidence documents the phenotypic and functional versatility of neutrophils far beyond their antimicrobial functions. Hence, understanding the receptors that integrate opposing cues and checkpoints that determine the fate of neutrophils in inflamed tissues provides insight into the mechanisms that distinguish protective and dysregulated, excessive inflammation and govern resolution. This review aims to provide a brief overview and update with key points from recent advances on neutrophil heterogeneity, functional versatility and signaling, and discusses challenges and emerging therapeutic approaches that target neutrophils to enhance the resolution of inflammation.
Neoadjuvant and Adjuvant Treatments Compared to Concurrent Chemoradiotherapy for Patients With Locally Advanced Cervical Cancer: A Bayesian Network Meta-Analysis

Aim This study aimed to identify the most effective treatment mode for locally advanced cervical cancer (LACC) by adopting a network meta-analysis (NMA). Methods Randomized controlled trials about treatments were retrieved from PubMed, Medline and Embase. Odds ratios (OR) of overall survival (OS) and progression-free survival (PFS) were calculated by synthesizing direct and indirect evidence to rank the efficacy of nine treatments. Consistency was assessed by node-splitting method. Begg’s test was performed to evaluate publication bias. The surface under cumulative ranking curve (SUCRA) was also used in this NMA. Results A total of 24 eligible randomized controlled trials with 6,636 patients were included in our NMA. These trials compared a total of nine different regimens: radiotherapy (RT) alone, surgery, RT plus adjuvant chemotherapy (CT), concurrent chemoradiotherapy (CCRT), neoadjuvant CT plus CCRT, CCRT plus adjuvant CT, neoadjuvant CT, RT, CCRT plus surgery. Among those therapeutic modalities, we found that the two interventions with the highest SUCRA for OS and PFS were CCRT and CCRT plus adjuvant CT, respectively. ORs and 95% confidence interval (CI) for the two best strategies were CCRT versus CCRT plus adjuvant CT (OR, 0.84; 95% CI, 0.53–1.31) for OS, CCRT plus adjuvant CT versus CCRT (OR, 0.60; 95% CI, 0.38–0.96) for PFS. Conclusions This NMA supported that CCRT and CCRT plus adjuvant CT are likely to be the most optimal treatments in terms of both OS and PFS for LACC. Future studies should focus on comparing CCRT and CCRT plus adjuvant CT in the treatment of LACC. Systematic Review Registration PROSPERO, CRD42019147920.
Combined Effects of Artificial Surface and Urban Blue-Green Space on Land Surface Temperature in 28 Major Cities in China

The two most common land cover types in urban areas, artificial surface (AS) and urban blue-green space (UBGS), interact with land surface temperature (LST) and exhibit competitive effects, namely, heating and cooling effects. Understanding the variation of these effects along the AS ratio gradient is highly important for the healthy development of cities. In this study, we aimed to find the critical point of the joint competitive effects of UBGS and AS on LST, and to explore the variability in different climate zones and cities at different development levels. An urban land cover map and LST distribution map were produced using Sentinel-2 images and Landsat-8 LST data, respectively, covering 28 major cities in China. On this basis, the characteristics of water, vegetation, and LST in these cities were analyzed. Moreover, the UBGS (water or vegetation)–AS–LST relationship of each city was quantitatively explored. The results showed that UBGS and AS have a competitive relationship and jointly affect LST; this competition has a critical point (threshold). When the proportion of UBGS exceeds this value, UBGS replaces AS as the dominant variable for LST, bringing about a cooling effect. In contrast, when AS dominates LST, it causes a warming effect. The critical points between AS and water and between AS and vegetation in 28 major cities in China were 80% and 70%, respectively. The critical point showed an obvious zonal difference. Compared with cities in subtropical and temperate climate regions, the critical point of arid cities is higher, and UBGS exhibited better performance at alleviating the urban thermal environment. The critical point of cities with higher development levels is lower than that of cities with lower development levels. Even areas with relatively low AS coverage are prone to high temperatures, and more attention should be paid to improving the coverage of UBGS. Our research results provide a reference for the more reasonable handling of the relationship between urban construction, landscape layout, and temperature control.
Effectiveness of Shear-Friction Reinforcement in Shear Diaphragm Capacity of Hollow-Core Slabs

' n addition to resisting superimposed gravity loads, precast concrete floor systems should be capable of transferring horizontal shear from earthquake or wind loadings to the main lateral load-resisting system. The floor is usually assumed to be infinitely rigid in its own plane and, therefore, capable of distributing horizontal shear to different lateral load-resisting units in proportion to their lateral stiffness. Compatibility is, thus, maintained at floor levels. Precast floor units composing such a floor system should be carefully connected together and to the lateral loadresisting system to insure an adequate load path for structural integrity and safety. Three methods of construction are commonly used; these are cast-inplace topping, welded hardware, and grouted joints. This paper covers the case of untopped precast hollow-core floor systems utilizing grouted joints. A design example based on shear-friction criteria is given and supporting experimental data are presented.
MODE, MOOD AND TRIP MANAGEMENT: A QUALITATIVE ANALYSIS OF THE EFFECTS OF RTPI ON BUS USER BEHAVIOUR AND ATTITUDES

1. ABSTRACT As part of a wider evaluation of a pilot Real Time Passenger Information (RTPI) system implemented along a Quality Bus Corridor in Edinburgh, UK, a household survey was conducted with residents living alongside the route, 4 months after the system was installed. Respondents were asked, inter alia, to state in an open-ended question the effects of the RTPI system on their behaviour and attitudes towards local bus use. Whilst only a small change in actual bus use was reported, many users reported changes in their attitudes in terms of reduced waiting time, perceived security, stress reduction, satisfaction with bus services and facilitation of journey planning. Analysis of responses supported a typology of three main effects of RTPI on: respondent’s modal choice (Mode Management), respondents’ state of mind whilst waiting for and using bus service (Mood Management) and ease of journey planning (Trip Management). The results are discussed in relation to current understanding of transport choice behavioural change models, suggesting the impact of RTPI is to retain, and to stimulate ‘behavioural intentions’ (to use buses more often) for existing passengers, rather than actual modal change per se.
Simulation and control of stationary crossflow vortices

Turbulent ﬂow and transition are some of the most important phenomena of ﬂuid mechanics and aerodynamics and represent a challenging engineering problem for aircraft manufacturers looking to improve aerodynamic eﬃciency. Laminar ﬂow technology has the potential to provide a significant reduction to aircraft drag by manipulating the instabilities within the laminar boundary layer to achieve a delay in transition to turbulence. Currently prediction and simulation of laminar-turbulent transition is con- ducted using either a low-ﬁdelity approach involving the stability equations or via a full Direct Numerical Simulation (DNS). The work in this thesis uses an alternative high-ﬁdelity simulation method that aims to bridge the gap between the two simulation streams. The methodology uses an LES approach with a low-computational cost sub-grid scale model (WALE) that has inherent ability to reduce its turbulent viscosity contribution to zero in laminar regions. With careful grid spacing the laminar regions can be explicitly modelled as an unsteady Navier-Stokes simulation while the turbulent and transitional regions are simulated using LES. The methodology has been labelled as an unsteady Navier-Stokes/Large Eddy Simulation (UNS/LES) approach. Two test cases were developed to test the applicability of the method to simulate and control the crossﬂow instability. The ﬁrst test case replicated the setup from an experiment that ran at a chord-based Reynolds number of 390, 000. Two methods were used to generate the initial disturbance for the crossﬂow vortices, ﬁrstly using a continuous suction hole and secondly an isolated roughness element. The results for this test case showed that the approach was capable of modelling the full transition process, from explicitly modelling the growth of the initial amplitude of the disturbances to ﬁnal breakdown to turbulence. Results matched well with the available experimental data. The second test case replicated an experimental setup using a custom- designed aerofoil run at a chord-based Reynolds number of 2.4 million. The test case used Distributed Roughness Elements (DRE) to induce crossﬂow vortices at both a critical and a control wavelength. By forcing the crossﬂow vortices at a stable (control) wavelength a delay in laminar-turbulent transition can be achieved. The results showed that the UNS/LES approach was capable of capturing the initial disturbance amplitudes due to the roughness elements and their growth rates matched well with experimental data. Finally, downstream a transitional region was assessed with low-freestream turbulence provided using a modiﬁed Synthetic Eddy Method (SEM). The full laminar-turbulent transition pro- cess was simulated and results showed signiﬁcant promise. In conclusion, the method employed in this thesis showed promising results and demonstrated a possible route to high-ﬁdelity transition simulation run at more realistic ﬂow conditions and geometries than DNS. Further work and validation is required to test the secondary instability region and the ﬁnal breakdown to turbulence.
The multiple mediating roles of self-esteem and happiness in the relationship between loneliness and depression in Facebook and Instagram users (eng)

Objective: Social media usage is increasing gradually and the websites that enable social interaction may influence people’s loneliness and depression levels. The aim of the present research was to examine the multiple mediating roles of self-esteem and happiness in the relationship between loneliness and depression. Method: The study sample was composed of 409 Facebook and Instagram users. Data were collected by using personal information form, Beck Depression Inventory, Oxford Happiness Scale-Short Form, Rosenberg Self-Esteem Scale and UCLA Loneliness Scale. Correlation analysis was carried out to determine the relationship between variables. Multiple mediation analysis was conducted to determine the mediating roles of self-esteem and happiness in the relationship between loneliness and depression. Results: The results suggest that self-esteem and happiness, indeed, have mediating roles in the relationship between loneliness and depression, and multiple mediation models were found to be statistically significant. The frequency of accessing Instagram was positively associated with depression and loneliness. Facebook users had higher self-esteem levels compared to Instagram users. Discussion: In conclusion, the relationship between loneliness and depression was found to be significantly mediated by self-esteem and happiness. Increased frequency of access to Instagram every day was found to increases the level of depression and loneliness. Additionally, Instagram users were found to have lower self-esteem compared to Facebook users.
A cross-sectional study on knowledge of registered medical practitioners, regarding management of medico-legal cases in Meghalaya

Introduction: Medico-legal issues are handled by every registered medical practitioner in their day-to-day medical practice but if they are not well versed with rules of managing such cases and laws behind them, they often land into criticism and are distressed at the courts while disposing of the cases. Objective: To assess the knowledge of registered medical practitioners in Meghalaya regarding the management of medico-legal cases in day-to-day medical practices. Materials and Methods: This was a cross-sectional study, conducted at the Department of Forensic Medicine, North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences (NEIGRIHMS) for 6 months. The study group included registered medical practitioners working in the government sector who were approached through the Director of Health Services (DHS), Meghalaya. Study tools included one preformed and pretested questionnaire. Knowledge was assessed along with designation and years of experience. A P value of < 0.05 was considered statistically significant. Results: From 94 subjects analyzed for their answers, 56% had adequate knowledge. Amongst nonspecialist doctors (n = 53), 52.8% had adequate knowledge and amongst specialist doctors (n = 34), 67.6% had adequate knowledge in various aspects of management of medico-legal cases, and it was found that 6.4% had adequate knowledge in documentation, 21.2% in consent, 3.2% in the Protection of Children from Sexual Offences (POCSO) Act, 71.2% in autopsy, 88.2% in legal duties in emergency care. A total of 68.7% of those having 16–20 years of experience had adequate knowledge. Chi-square test of designation and years of experience on knowledge was found to be 0.33 and 0.75, respectively. Conclusion: Nearly half of the registered medical practitioners of Meghalaya have adequate knowledge. However, years of experience and designation have no significance with the knowledge of registered medical practitioners regarding the management of medico-legal issues.
Predictors of quality of life among geriatric population in a tribal dominant state of India: A community based analytical study

Background: Improving the quality of life of the geriatric population along with maintaining their health and promoting social participation still poses a major public health challenge in the twenty-first century. Hence, we planned to measure the quality of life (QOL) in each domain namely physical, psychological, social, and environmental using the world health organization quality of life brief version (WHO QOL-BREF) questionnaire and to assess the predictors of QOL among the elderly population. Methodology: A community-based cross-sectional study was conducted in Ormanjhi, Ranchi, Jharkhand for a period of 6 months. The study was carried out among 206 geriatric populations fulfilling the eligibility criteria. The data collected were entered in MS Excel and analyzed using SPSS version 20. The QOL scores were expressed in terms of mean and standard deviation, and the difference between mean scores was tested by using student t-test/analysis of variance (ANOVA). The predictor associated with QOL was done by multiple linear regression analysis. P value less than 0.05 was considered statistically significant. Results: A total of 206 geriatric people fulfilling the study criteria were enrolled during the study. The majority of the people were of the age between 60 and69 years (71.8%). Most of them 202 (98.1%) resided in rural areas, 108 (52.4%) of them were illiterate by education, and nearly half 102 (49.5%) depended on pension for livelihood. Nontribal ethnicity, backward category, illiteracy, low socio-economic status, nuclear family, elderly person having no own source of income, currently living alone, person having more co-morbidity, and less activities of daily living (ADL) score were significantly associated with low QOL score. Conclusion: Overall QOL was good to excellent in Ranchi, Jharkhand. We concluded that QOL is affected by many different factors.
Out-of-pocket spending on hypertension and diabetes among patients reporting in a health -care teaching institute of the Western Rajasthan

Background: Across the globe, morbidity and mortality due to non-communicable diseases (NCDs) are major public health issues. The resulting concern is not just epidemiological but also about the economic consequences at the household level. Objective: To assess the various facets of out-of-pocket spending (OOPs) incurring on NCDs, namely hypertension and diabetes on patients attending a healthcare teaching institute in Rajasthan. Methodology: This cross-sectional study involves patients older than 18 years attending either out-patient clinics or who were admitted in the wards in a healthcare teaching institute for seeking care for diabetes or hypertension. Four hundred patients were chosen purposively and a pretested questionnaire was used to elicit information on incurring OOPs for NCDs. Descriptive statistics (like percentage, mean, median, and standard deviation) were calculated. Results: The study shows a significant expenditure other than out-patient, in-patient admissions, in the form of personal expenditure and loss of employment, amounting to 31.86 and 34.07%, respectively, of the mean total expenditure. In a quarter (3 months), the mean total expenditure is ₹9014.37 ± 6452.37. On average, the OOP expenditure per visit for an out-patient visit was ₹370.54 ± 237, while for the patients admitted to the hospital, the average OOPs was ₹1564.72 ± 1310.5. Conclusions: Health expenditures can contribute toward the impoverishment of many segments of the community. Undoubtedly, numerous people may tend to neglect the needed care for NCDs due to financial hurdles. Thus, there is a need to develop NCD care management centers with health insurance packages and make them accessible for all.
Prevalence and predictors of hypertension: Evidence from a study of rural India

Background: Raised blood pressure (BP) is the leading global risk factor for cardiovascular diseases and a major cause of premature death. Worldwide, one in four men and one in five women are hypertensive. For effective preventive strategy, understanding of predictors of hypertension is necessary. Objective: To assess prevalence and predictors of hypertension in the rural adult Indian population. Material and Methods: This cross-sectional study was carried out on 425 rural subjects (25–64 years) of the Varanasi district in India selected through multistage sampling. Blood pressure of each subject was measured using a standard technique. Sociodemographic data and predictors of hypertension were assessed by interviewing subjects with help of a predesigned and pretested proforma. Results: Prevalence of hypertension was 31.5% (95% CI: 27.1–35.9). There existed a significant (P < 0.05) association of BP with age, educational status, occupation, socioeconomic class, tobacco consumption, waist circumference, waist-hip ratio, and nutritional status. No significant association was found with gender, religion, caste, marital status, type and size of family, family without NCDs, awareness of screening camps for NCDs and national program for prevention and control of cancer, diabetes, cardiovascular diseases and stroke, and alcohol consumption. Significant association of education, nutritional, and occupational status obtained in univariate analysis got eliminated in the logistic model. Risk of hypertension was higher in the 45–64 years age group (AOR: 3.06; 95% CI: 1.75–5.35) and in socioeconomic class IV and V (AOR: 2.24; 95% CI: 1.17–4.31). Conclusion: Prevalence of hypertension in the rural population was high and most of the observed predictors were modifiable.
Implications of β-thalassemia on oral health status in patients: A cross-sectional study

Background: β-Thalassemia is a chronic disease of autosomal recessive origin that is identified by the presence of a severe form of anemia. This hematological disease has been shown to directly influence a person's physical as well as psychological well-being along with their families. Aim: This study aimed to find an association between dental health status and oral health-related quality of life (QoL) among children who have been diagnosed with β-thalassemia. Materials and Methods: This prospective cross-sectional study was carried out in the dental outpatient department; blood bank and pediatric outpatient departments that were associated with the primary institute. All study participants were age-ranged from 3 to 15 years. Informed written consent was obtained from caregivers or parents of all the study participants. This study was conducted for a total duration of 1 year (from June 2020 to June 2021). All study participants were categorized into two groups: (a) Group I (n = 150) comprised children who were diagnosed with β-thalassemia and (b) Group II (n = 150) comprised normal controls. Exclusion criteria in the study included children suffering from any systemic disease that predisposes them to dental caries or periodontal diseases. The intra-oral examination was performed using Decayed-Missing-Filled Teeth Index (DMFT/dmft Index) and Oral Hygiene Index-Simplified (OHI-S). Assessment of QoL was done by using the “Child Perceptions Questionnaire for children. ” Collected data were recorded in Microsoft Excel workbook, 2007. Statistical comparison between both the groups was performed by using statistical tools such as the Chi-square test, Fisher's exact test, independent t-test, and Mann–Whitney U test. The probability values lesser than 0.05 were considered to be statistically significant. Results: Maxillofacial findings—rodent facies, saddle nose, lip incompetence, pale oral mucosa, anterior open-bite, lower anterior teeth crowding, and maxillary anterior teeth spacing or crowding—were seen. Class II malocclusion was present in significant numbers of subjects. On comparing dmft/DMFT scores, no significance was observed while on comparing OHI-S index, statistical significance was seen. A statistically significant difference in the QoL was noted between thalassemic children and the control group. Conclusion: Thalassemic children showed a significant association between dental health and QoL.