Miracle-dz/UniFAR-FTUs huggingface dataset:
Permeability due to the Increase of Damage in Concrete: From Diffuse to Localized Damage Distributions

Experimental tests exhibit a strong interaction between material damage and transport properties of concrete. There are at least two asymptotic cases where some theoretical modeling exists: in the case of diffuse cracking, the material permeability should be controlled by damage, e.g., by the decrease of average stiffness due to microcracking. In the case of localized microcracking, and after a macrocrack has formed, permeability should be controlled by a power function of the crack opening (Poiseuille flow). For quasi-brittle materials with evolving microstructure due to mechanical loads, a transition regime on the evolution of permeability between these two asymptotic cases is expected. In this contribution, we define a relationship between permeability and damage that is consistent with the two above configurations. One of the key issues is to relate the crack opening to the state variables in the continuum approach, so that the two asymptotic cases are expressed in the same variable system and can be matched. A simplified approach is used for this purpose. The permeability law is then derived using a mixing formula that weights each asymptotic regime with damage. To illustrate the influence of the matching law on structural response, finite-element simulations of a Brazilian splitting test and a comparison with existing test data are presented.
The Augmented Synthetic Control Method

Abstract The synthetic control method (SCM) is a popular approach for estimating the impact of a treatment on a single unit in panel data settings. The “synthetic control” is a weighted average of control units that balances the treated unit’s pretreatment outcomes and other covariates as closely as possible. A critical feature of the original proposal is to use SCM only when the fit on pretreatment outcomes is excellent. We propose Augmented SCM as an extension of SCM to settings where such pretreatment fit is infeasible. Analogous to bias correction for inexact matching, augmented SCM uses an outcome model to estimate the bias due to imperfect pretreatment fit and then de-biases the original SCM estimate. Our main proposal, which uses ridge regression as the outcome model, directly controls pretreatment fit while minimizing extrapolation from the convex hull. This estimator can also be expressed as a solution to a modified synthetic controls problem that allows negative weights on some donor units. We bound the estimation error of this approach under different data-generating processes, including a linear factor model, and show how regularization helps to avoid over-fitting to noise. We demonstrate gains from Augmented SCM with extensive simulation studies and apply this framework to estimate the impact of the 2012 Kansas tax cuts on economic growth. We implement the proposed method in the new augsynth R package.
Improved Parameterization of Protein–DNA Interactions for Molecular Dynamics Simulations of PCNA Diffusion on DNA

Here, we quantitatively evaluate the accuracy of the protein–DNA interactions in AMBER and CHARMM force fields by comparing experimental and simulated diffusion coefficients of proliferating cell nuclear antigen (PCNA). We find that both force fields underestimate diffusion coefficients by at least an order of magnitude because the interactions between basic amino acids and DNA phosphate groups are too attractive. Then, we propose Lennard-Jones parameters optimized using the experimental osmotic pressure data of model chemicals, by using which one can reproduce the experimental diffusion coefficients. Newly optimized parameters will have a broad impact on general protein–DNA interactions.
Earnings-Based Borrowing Constraints and Macroeconomic Fluctuations

Microeconomic evidence reveals a direct link between firms' current earnings and their access to debt. This paper studies macroeconomic implications of earnings-based borrowing constraints. In a macro model, firms with earnings-based constraints borrow more in response to positive investment shocks, whereas firms with collateral constraints borrow less. Empirically, aggregate and firm-level credit responds to identified investment shocks according to the predictions with earnings-based constraints. Moreover, with sticky prices, earnings-based constraints imply that supply shocks are quantitatively more important. This is validated in an estimated version of the model, highlighting the importance of carefully modeling credit constraints to understand policy trade-offs. (JEL E22, E32, G31, G32)
Innate Immune Components That Regulate the Pathogenesis and Resolution of hRSV and hMPV Infections

The human respiratory syncytial virus (hRSV) and human Metapneumovirus (hMPV) are two of the leading etiological agents of acute lower respiratory tract infections, which constitute the main cause of mortality in infants. However, there are currently approved vaccines for neither hRSV nor hMPV. Moreover, despite the similarity between the pathology caused by both viruses, the immune response elicited by the host is different in each case. In this review, we discuss how dendritic cells, alveolar macrophages, neutrophils, eosinophils, natural killer cells, innate lymphoid cells, and the complement system regulate both pathogenesis and the resolution of hRSV and hMPV infections. The roles that these cells play during infections by either of these viruses will help us to better understand the illnesses they cause. We also discuss several controversial findings, relative to some of these innate immune components. To better understand the inflammation in the lungs, the role of the respiratory epithelium in the recruitment of innate immune cells is briefly discussed. Finally, we review the main prophylactic strategies and current vaccine candidates against both hRSV and hMPV.
The N-Terminal Acetyltransferase Naa50 Regulates Arabidopsis Growth and Osmotic Stress Response.

N-terminal acetylation is one of the most common protein modifications in eukaryotes. The function of Naa50, the catalytic subunit of the evolutionarily conserved N-terminal acetyltransferase E complex, has not been reported in Arabidopsis. In this study, we found that a loss of Naa50 resulted in a pleiotropic phenotype that included dwarfism and sterility, premature leaf senescence, and a shortened primary root. Further analysis revealed that root cell patterning and various root cell properties were severely impaired in naa50 mutant plants. Moreover, defects in auxin distribution were observed due to the mislocalization of PIN auxin transporters. In contrast to its homologs in yeast and animals, Naa50 showed no co-immunoprecipitation with any subunit of the N-terminal acetyltransferase A complex. Moreover, plants lacking Naa50 displayed hypersensitive to abscisic acid and osmotic stress. Therefore, our results suggest that protein N-terminal acetylation catalyzed by Naa50 plays an essential role in Arabidopsis growth and osmotic stress responses.
Three-dimensional natural convection of CNT-water nanofluid confined in an inclined enclosure with Ahmed body

h T ' Hot temperature (K) To Bulk temperature [To = ( ' T c+ ' T h) / 2] (K) V  Dimensionless velocity vector (  / '.l V  ) x, y, z Dimensionless coordinates( l x / ' , l y / ' , l z / ' ) Greek symbols  Thermal diffusivity (m /s)  Thermal expansion coefficient (1/K)  Density (kg/m)  Dynamic viscosity (kg./m.s)  Kinematic viscosity (m/s)  Nanoparticle or solid volume fraction  Cavity inclination   Dimensionless vector potential (   / '  )   Dimensionless vorticity ( 2 / '. l    ) T  Dimensionless temperature difference Subscripts x, y, z Cartesian coordinates fr Friction f Fluid av Average nf Nanofluid s Solid th Thermal tot Total Superscript ‘ Dimensional variable
A New Tribe of the Ladybird Beetle Subfamily Microweiseinae (Coleoptera: Coccinellidae) Discovered on an Island in the North Atlantic Ocean

Microweiseinae is a quite recently established subfamily within ladybird beetles (Coccinellidae). According to recent analyses of morphological and molecular data, it has been divided into three tribes. Members of the subfamily are distributed mostly in tropical and subtropical regions of the world. Despite several recent taxonomical studies of this group, its diversity and distribution is still not fully understood. Recent field collecting on Madeira Island resulted in the discovery of interesting specimens belonging to a yet unknown taxon, described here as Madeirodula atlantica gen. et sp. nov. Phylogenetic analysis of morphological characters indicate that the new taxon form a distinct branch within the subfamily Microweiseinae, for which we propose a new tribe Madeirodulini trib. nov. Evolutionary trends within the subfamily are discussed, and an updated key to the tribes of Microweiseinae is provided.
Coordination and Continuous Choice December 2016

We study a coordination game where players choose what information to acquire about payoffs prior to the play of the game. We allow general information acquisition technologies, modeled by a cost functional defined on information structures. A cost functional satisfies continuous choice if players choose a continuous decision rule even in a decision problem with discontinuous payoffs. If continuous choice holds, there is a unique equilibrium; if it fails, there are multiple equilibria. We show how continuous choice captures the idea that it is suffi ciently harder to distinguish states that are close to each other relative to far away states. JEL: C72 D82
Modulated Photocurrent Spectroscopy Study of the Electronic Transport Properties of Working Organic Photovoltaics: Degradation Analysis

Electronic transport measurement using modulated photocurrent (MPC) spectroscopy is demonstrated herein in working organic photovoltaics (OPVs) before and after AM1.5G irradiation. OPVs with bulk heterojunction (BHJ) using prototypical donor and acceptor materials, poly[[4,8-bis[(2-ethylhexyl)oxy]benzo[1–2-b:4,5-b′]dithiophene-2,6-diyl][3-fluoro-2-[(2-ethylhexyl)carbonyl] = hieno [3–4-b]thiophenediyl]] (PTB7) and [6,6]-phenyl-C71-butyric acid methyl ester (PC71BM), were fabricated. The OPVs had inverted structures (BHJs are formed on transparent conductive oxide substrates). The photovoltaic performance of PTB7:PC71BM OPVs was characterized and the best power conversion efficiency was obtained at PTB7 content of 40 wt%. Electron and hole mobility were determined with MPC spectroscopy in PTB7:PC71BM OPVs and were well balanced at PTB7 content of 40 wt%. Degradation of the photovoltaic performance of PTB7:PC71BM OPVs with PTB7 content of 40 wt% caused by AM1.5G irradiation was studied. MPC spectroscopy showed that the well-balanced mobility was not affected by AM1.5G irradiation. The degradation of OPVs was not due to changes in the electronic transport properties, but mainly to the reduced short circuit current (Jsc) and fill factor (FF). The origin of this reduction is discussed.
Formative Assessment in Mathematics Part 2: Feedback

This is the second of three articles reviewing the effectiveness of formative assessment, summarising the findings of a review of over 200 studies into formative assessment (Black and Wiliam, 1998). The focus of this article is the effect that feedback to learners about their past performance has on their future performance and their attitudes towards their learning. In particular, what kinds of feedback are the most effective in promoting learning?
Toward an understanding of trait competition, cooperation and explicit intergroup prejudice

ABSTRACT We sought to measure whether, and to what extent, correlations existed between trait-level cooperation and competition and different forms of intergroup prejudice. We recruited two samples of heterosexual European-American participants (n = 113 and n = 223) from a U.S. national panel survey service. Participants completed measures of racial, gender, and sexual orientation prejudice as questionnaires. In both samples, we found that trait competition tended to positively correlate with explicit measures, such that increasing trait competition was associated with higher degrees of prejudice. Interestingly, we found that different “families” of prejudice had different correlational profiles with trait competition, such that those with racial and gender prejudice had larger magnitudes than sexual orientation prejudice. Separately, trait cooperation only correlated reliably with prejudicial attitudes toward African Americans, such that increasing trait cooperation was associated with lower levels of prejudice.
CO, H2O, H2O+ line and dust emission in a z = 3.63 strongly lensed starburst merger at sub-kiloparsec scales

Using the Atacama Large Millimeter/submillimeter Array (ALMA), we report high angular-resolution observations of the redshift z = 3.63 galaxy H-ATLAS J083051.0+013224 (G09v1.97), one of the most luminous strongly lensed galaxies discovered by the Herschel-Astrophysical Terahertz Large Area Survey (H-ATLAS). We present 0. ″2−0. ″4 resolution images of the rest-frame 188 and 419 μm dust continuum and the CO(6–5), H2O(211−202), and Jup = 2 H2O+ line emission. We also report the detection of H2O(211−202) in this source. The dust continuum and molecular gas emission are resolved into a nearly complete ∼1. ″5 diameter Einstein ring plus a weaker image in the center, which is caused by a special dual deflector lensing configuration. The observed line profiles of the CO(6–5), H2O(211−202), and Jup = 2 H2O+ lines are strikingly similar. In the source plane, we reconstruct the dust continuum images and the spectral cubes of the CO, H2O, and H2O+ line emission at sub-kiloparsec scales. The reconstructed dust emission in the source plane is dominated by a compact disk with an effective radius of 0.7 ± 0.1 kpc plus an overlapping extended disk with a radius twice as large. While the average magnification for the dust continuum is μ ∼ 10−11, the magnification of the line emission varies from 5 to 22 across different velocity components. The line emission of CO(6–5), H2O(211−202), and H2O+ have similar spatial and kinematic distributions. The molecular gas and dust content reveal that G09v1.97 is a gas-rich major merger in its pre-coalescence phase, with a total molecular gas mass of ∼1011 M⊙. Both of the merging companions are intrinsically ultra-luminous infrared galaxies (ULIRGs) with infrared luminosities LIR reaching ≳4 × 1012 L⊙, and the total LIR of G09v1.97 is (1.4 ± 0.7)×1013 L⊙. The approaching southern galaxy (dominating from V = −400 to −150 km s−1 relative to the systemic velocity) shows no obvious kinematic structure with a semi-major half-light radius of as = 0.4 kpc, while the receding galaxy (0 to 350 km s−1) resembles an as = 1.2 kpc rotating disk. The two galaxies are separated by a projected distance of 1.3 kpc, bridged by weak line emission (−150 to 0 km s−1) that is co-spatially located with the cold dust emission peak, suggesting a large amount of cold interstellar medium (ISM) in the interacting region. As one of the most luminous star-forming dusty high-redshift galaxies, G09v1.97 is an exceptional source for understanding the ISM in gas-rich starbursting major merging systems at high redshift.
Experiences of stigma in healthcare settings by people living with HIV in Ireland: a qualitative study

ABSTRACT Stigma in healthcare settings remains a barrier to accessing screening, treatment and care for HIV and is a driver of the global HIV epidemic. This study examined the stigma experiences in healthcare settings of people living with HIV (PLHIV) in Ireland. Semi-structured interviews were carried out with 4 women and 10 men living with HIV. Data were analysed using a Directed Content Analysis approach to assess experiences of enacted, anticipated and internalised stigma. The findings indicate experiences of enacted, anticipated and internalised stigma were common. A further finding of spatial stigma was also uncovered. Analysis showed these experiences impacted participants’ engagement with care and affected health-seeking behaviours and treatment adherence. The results suggest stigma experienced in healthcare settings may impact negatively on health outcomes.
Volatile Profiling of Strawberry Fruits Cultivated in a Soilless System to Investigate Cultivar-Dependent Chemical Descriptors

Volatile compounds are essential for food organoleptic characteristics and of great utility for the food industry as potential markers for authenticity purposes (e.g., variety, geographical origin, adulteration). The aim of this study was to determine the characteristic volatile compounds of strawberry samples grown in a soilless system by using headspace solid phase micro-extraction coupled with gas chromatography and to investigate the influence of cultivar (Festival, Candonga, Camarosa) on this volatile profile. We observed that Festival and, to a lesser extent, Candonga varieties were characterized by the richest aroma-related profiles, including higher levels of esters, furanones and terpenes. In particular, methyl butyrate, hexyl hexanoate, linalool, geraniol and furaneol were the most abundant aromatic compounds detected in the three varieties of strawberries. Complementarily, the application of pattern recognition chemometric approaches, including principal component analysis and linear discriminant analysis, demonstrated that concentrations of specific volatiles can be employed as chemical descriptors to discriminate between strawberry cultivars. Accordingly, geraniol and hexyl hexanoate were found to be the most significant volatiles for the discrimination of strawberry varieties.
High-pressure geophysical properties of fcc phase

Face centered cubic (fcc) FeHX was synthesized at pressures of 18 to 68 GPa and temperatures exceeding 1500 K. Thermally quenched samples were evaluated using synchrotron X-ray diffraction (XRD) and nuclear resonant inelastic X-ray scattering (NRIXS) to determine sample composition and sound velocities to 82 GPa. To aid in the interpretation of non-ideal (X≠1) stoichiometries, two equations of state for fcc FeHX were developed, combining an empirical equation of state for iron with two distinct synthetic compression curves for interstitial hydrogen. Matching the density deficit of the Earth’s core using these equations of state requires 0.8-1.1 wt. % hydrogen at the core-mantle boundary and 0.2-0.3 wt. % hydrogen at the interface of the inner and outer cores. Furthermore, a comparison of Preliminary Reference Earth Model (PREM) [Dziewonski and Anderson; 1981] to a Birch’s law extrapolation of our experimental results suggests that an iron alloy containing ~0.8 to 1.3 wt. % hydrogen could reproduce both the density and compressional velocity (VP) of the Earth’s outer core.
Effect of Palmitic Acid on Exosome-Mediated Secretion and Invasive Motility in Prostate Cancer Cells

High fat consumption can enhance metastasis and decrease survival in prostate cancer, but the picture remains incomplete on the epidemiological and cell-biological level, impeding progress toward individualized recommendations in the clinic. Recent work has highlighted the role of exosomes secreted by prostate cancer cells in the progression of the disease, particularly in metastatic invasion, and also the utility of targeting these extracellular vesicles for diagnostics, as carriers of disease progression markers. Here, we investigated the question of a potential impact of the chief nutritional saturated fatty acid on the exosome secretion. Palmitic acid decreased the secretion of exosomes in human prostate cancer cells in vitro in a concentration-dependent manner. At the same time, the content of some prospective metastatic markers in the secreted exosomal fraction was also reduced, as was the ability of the cells to invade across extracellular matrix barriers. While by themselves our in vitro results imply that on the cell level, palmitic acid may be beneficial vis-à-vis the course of the disease, they also suggest that, by virtue of the decreased biomarker secretion, palmitic acid has the potential to cause unjustified deprioritization of treatment in obese and lipidemic men.
Non-Fire Related Carbon Monoxide Poisoning in Sichuan, China: A 9-Year Study (2008–2016)

Background: Carbon monoxide (CO) poisoning is one of the most important intoxications in the modern world. This study aimed to identify the characteristics of CO poisoning deaths in Sichuan province in the west of China. Methods: Data on fatal non-fire-related carbon monoxide poisoning in Sichuan from 2008 to 2016 were obtained from the Department of Forensic Analytical Toxicology of Sichuan University and were analyzed by the month and year of registration of death, sex, age group, manner of death, source of CO, and location of CO exposure. Comparing with the previous studies carried out in Wuhan and Shanghai to identify the regional differences of CO poisoning in China. Results: A total of 165 non-fire related CO poisoning cases including 237 victims were recorded. Over 90% of the victims died from accidental poisoning. Non-fire related CO poisoning occurred more frequently in winter months and was most prevalent in individuals aged between 18 and 60 yr old. Showering gas accident and coal or charcoal burning was found to be the major source of CO in accident and in suicide cases, respectively. Furthermore, significant regional differences of CO poisoning have been detected in the manner of death and the source of CO. Conclusion: These findings will be valuable in the targeted prevention of non-fire related CO poisoning in China.
Are Base of Pyramid (BoP) Consumers Willing to Pay for Nutritious Foods? Evidence from Kenya and Uganda

The Base of the Pyramid (BoP) consumers living in the urban informal settlement of developing countries spend over 60% of their income on food, yet malnutrition and micronutrient deficiency remains widespread among this population, pointing to the inadequacy of the foods they consume in terms of quality and quantity. In this paper we examine BoP consumer willingness to pay (WTP) for safe and nutritious multicomposite porridge flour (improved flour) in the informal settlements of Nairobi, Kenya and Kampala, Uganda. In 2016, we collected primary data from 600 consumers in the informal settlements of Kampala, Uganda and Nairobi, Kenya (300 in Kenya and 300 in Uganda). We use Tobit regression models to analyse determinants of WTP for the improved flour. Results show that both Kenyan and Ugandan consumers are willing to pay a premium for the improved flour. In addition, providing nutrition information of the flour, characteristics of household head, economic status of the household, and presence of young children between 6 and 59 months in the household influence WTP for the safe and nutritious porridge flour. The paper concludes by providing recommendations for enhancing nutrition among poor consumers in the informal settlements of developing countries.
A review of health and wellness studies involving Inuit of Manitoba and Nunavut

ABSTRACT The purpose of this review is to summarise past Inuit health and wellness studies in Manitoba and the Kivalliq region of Nunavut to provide a snapshot of the types of studies available and identify the gaps in knowledge. Research to date has largely been disease-based and often provides comparisons between Indigenous and non-Indigenous people. Distinct Inuit experiences are rarely written about from an Inuit perspective. However, Inuit Tapiriit Kanatami, the national organisation of Inuit in Canada, and Pauktuutit Inuit Women of Canada have been leaders in strengths-based community research and publications that address priorities determined by the Inuit, including the 2018 Inuit Tapiriit Kanatami document National Inuit Strategy on Research (132).