Miracle-dz/UniFAR-FTUs huggingface dataset:
Charge Transport and Recombination in a Nanoscale Interpenetrating Network of n-Type and p-Type Semiconductors: Transient Photocurrent and Photovoltage Studies of TiO2/Dye/CuSCN Photovoltaic Cells

Solid-state dye-sensitized photovoltaic cells have been fabricated with TiO2 as the electron conductor and CuSCN as the hole conductor. These cells involve the nanoscale mixing of crystalline n-type and p-type semiconductors in films that are more than 100 times thicker than the individual n- and p-type domains. Charge transport and field distribution in this kind of material are as yet unexplored. We have used photocurrent and photovoltage transients, combined with variation in the layer thickness, to examine the limiting factors in charge transport and recombination. Charge transport (t1/2 ≈ 200 μs) is found to be similar to that in dye-sensitized electrolyte cells. Recombination at Voc (t1/2 ≈ 150 μs) is 10 times faster than in electrolyte cells, and recombination at short circuit (t1/2 ≈ 450 μs) is 100 times faster. In the solid-state cells, the similarity of the charge transport and recombination rates results in a low fill factor, and photocurrent losses, both important limiting factors of the effic.
Speaking of Values: Value-Expressive Communication and Exercise Intentions

ABSTRACT This study introduces the concept of value-expressive communication and examines its relationship with behavioral intent. Value-expressive communication is conceptualized as the verbal output of a value-expressive attitude. Value-expressive communication about exercise is examined in relationship to strength of religious faith, exercise attitudes, communication frequency, and intentions to exercise among a sample of self-identified Christians. The data indicate a significant interaction between value-expressive communication and communication frequency explains significant variance in exercise intentions. Interact to and exercise attitudes is significantly associated with intentions to exercise. Suggestions for using value-expressive communication in health communication research and practice are discussed.
The ecdysone-induced protein 93 is a key factor regulating gonadotrophic cycles in the adult female mosquito Aedes aegypti

Significance In female mosquitoes, repeated blood feedings are essential for maintaining gonadotrophic cycles and serve as the basis for pathogen transmission. We demonstrate that the ecdysone-induced protein 93 (E93), a transcription factor implicated in insect metamorphic transitions, regulates reproductive switches in adult females of the major arboviral vector Aedes aegypti. E93 RNA interference before the first gonadotrophic cycle disrupts the second. E93 silencing disturbed the expression of Hormone Receptor 3 and autophagy, both essential for vitellogenesis termination. Transcriptomic analysis reveals a E93-mediated shutdown of gene expression during the end of a reproductive cycle, particularly genes linked to translation, yolk protein precursors, and metabolism. This study has advanced our understanding of the E93 role in controlling the gonadotrophic cyclicity in female mosquitoes. Repeated blood feedings are required for adult female mosquitoes to maintain their gonadotrophic cycles, enabling them to be important pathogen carriers of human diseases. Elucidating the molecular mechanism underlying developmental switches between these mosquito gonadotrophic cycles will provide valuable insight into mosquito reproduction and could aid in the identification of targets to disrupt these cycles, thereby reducing disease transmission. We report here that the transcription factor ecdysone-induced protein 93 (E93), previously implicated in insect metamorphic transitions, plays a key role in determining the gonadotrophic cyclicity in adult females of the major arboviral vector Aedes aegypti. Expression of the E93 gene in mosquitoes is down-regulated by juvenile hormone (JH) and up-regulated by 20-hydroxyecdysone (20E). We find that E93 controls Hormone Receptor 3 (HR3), the transcription factor linked to the termination of reproductive cycles. Moreover, knockdown of E93 expression via RNAi impaired fat body autophagy, suggesting that E93 governs autophagy-induced termination of vitellogenesis. E93 RNAi silencing prior to the first gonadotrophic cycle affected normal progression of the second cycle. Finally, transcriptomic analysis showed a considerable E93-dependent decline in the expression of genes involved in translation and metabolism at the end of a reproductive cycle. In conclusion, our data demonstrate that E93 acts as a crucial factor in regulating reproductive cycle switches in adult female mosquitoes.
Student Motivation and Associated Outcomes: A Meta-Analysis From Self-Determination Theory

Student outcomes are influenced by different types of motivation that stem from external incentives, ego involvement, personal value, and intrinsic interest. The types of motivation described in self-determination theory each co-occur to different degrees and should lead to different consequences. The associations with outcomes are due in part to unique characteristics and in part to the degree of autonomy each entails. In the current meta-analysis, we examine these different types of motivation in 344 samples (223,209 participants) as they relate to 26 performance, well-being, goal orientation, and persistence-related student outcomes. Findings highlight that intrinsic motivation is related to student success and well-being, whereas personal value (identified regulation) is particularly highly related to persistence. Ego-involved motives (introjected regulation) were positively related to persistence and performance goals but also positively related with indicators of ill-being. Motivation driven by a desire to obtain rewards or avoid punishment (external regulation) was not associated with performance or persistence but was associated with decreased well-being. Finally, amotivation was related to poor outcomes. Relative weights analysis further estimates the degree to which motivation types uniquely predict outcomes, highlighting that identified regulation and intrinsic motivation are likely key factors for school adjustment.
Inertia, innovation, and cross-lagged effects in negative affect and rumination: daily diary study among people living with HIV

ABSTRACT Objective The aim of this study was to examine individual differences in the day-by-day relationship between negative affect (NA) and rumination in terms of their inertia, innovation, and cross-lagged effects among people living with HIV (PLWH). Methods The participants were 217 PLWH with confirmed diagnoses of HIV and undergoing antiretroviral treatment. They assessed their NA and rumination for five consecutive days each evening via an online survey. Results Results showed that inertia in NA is negatively related to inertia in rumination. Both innovations were unrelated. However, the individuals with relatively higher overall NA were also more reactive to external factors and/or had more variability in their daily lives, to which they respond with NA. Finally, the autoregressive effects were revealed to be important for spillover effects in a direction that is coherent with a given inertia. Thus, the direction of the cascade between daily NA and rumination depends on the area of major regulatory weakness. Conclusion The results support the view that intensity, inertia, and innovation are distinct dimensions in spite of the common assumption that higher overall intensity of emotions and coping should be strongly related or even synonymous to their perseveration.
Intra-individual cytokine profile in peri-implantitis and periodontitis: a cross-sectional study.

AIM To study cytokine profiles and intra-individual correlations in crevicular fluid samples at periodontitis, peri-implantitis, and healthy sites. MATERIALS AND METHODS Samples from gingival crevicular fluid (GCF) and peri-implant crevicular fluid (PICF) were collected from healthy and diseased sites in patients who had had dental implants for a minimum of 10 years. Cytokine levels were analyzed using the Bio-Plex Pro Human inflammation kit, which included biomarkers for the tumor necrosis factor-α (TNF-α) superfamily, regulatory T Cell (Treg) cytokines, and interferon (IFN) proteins. RESULTS GCF/PICF cytokine levels, determined in samples from 163 patients, were frequently lower for healthy tooth and implant sites compared to sites with periodontitis or peri-implantitis. In contrast, there were no significant differences in cytokine levels between peri-implant sites and periodontitis sites. Intra-individual correlations between cytokines at peri-implant sites were frequently significant. In addition, the cytokines IFN-λ1 and TNFSF12 were significantly correlated with the presence of peri-implantitis. CONCLUSION Within the limits of this study, the intra-individual cytokine profile did not differ between sites diagnosed with periodontitis and those diagnosed with peri-implantitis, but did differ between healthy tooth and healthy implant sites. Studying intra-individual cytokine profiles is a method to elucidate possible differences between the etiopathogeneses of periodontitis and peri-implantitis, since it is well known that immune responses to dysbiosis vary between individuals according to host factors. Thus, the findings of the present study are potentially relevant to the advancement of knowledge in this field.
Expanding Coefficient: A Parameter To Assess the Stability of Induced-Fit Complexes

Here we propose a new parameter, the Expanding Coefficient (EC), that can be correlated with the thermodynamic stability of supramolecular complexes governed by weak secondary interactions and obeying the induced-fit model. The EC values show a good linear relationship with the log Kapp of the respective pseudorotaxane complexes investigated. According to Cram’s Principle of Preorganization, the EC can be considered an approximate mechanical measure of the host’s reorganization energy cost upon adopting the final bound geometry.
Factors Contributing to Adolescents’ and Young Adults’ Participation in Web-Based Challenges: Survey Study

Background Web-based challenges, phenomena that are familiar to adolescents and young adults who spend large amounts of time on social media, range from minimally harmful behaviors intended to support philanthropic endeavors to significantly harmful behaviors that may culminate in injury or death. Objective This study aims to investigate the beliefs that lead adolescents and young adults to participate in these activities by analyzing the amyotrophic lateral sclerosis (ALS) ice bucket challenge, representing nonharmful behaviors associated with web-based challenges, and the cinnamon challenge, representing web-based challenges that lead to harmful behaviors. Methods A retrospective quantitative study was conducted with a total of 471 participants aged between 13 and 35 years who either had participated in the ALS ice bucket challenge or the cinnamon challenge, or had never participated in any web-based challenge. Binomial logistic regression models were used to classify those who participated in the ALS ice bucket challenge or cinnamon challenge versus those who did not engage in either challenge using the integrated behavioral model’s beliefs as predictors. Results The findings showed that participants of both the cinnamon challenge and the ALS ice bucket challenge had significantly greater expectations from the public to participate in the challenge they completed in comparison with individuals who never participated in any challenge (P=.01 for the cinnamon challenge and P=.003 for the ALS ice bucket challenge). Cinnamon challenge participants had greater value for the outcomes of the challenge (P<.001) and perceived positive public opinion about the challenge (P<.001), in comparison with individuals who never participated in any challenge. In contrast, ALS ice bucket challenge participants had significantly greater positive emotional responses than individuals who never participated in any challenge (P<.001). Conclusions The constructs that contribute to the spread of web-based challenges vary based on the level of self-harm involved in the challenge and its purpose. Intervention efforts could be tailored to address the beliefs associated with different types of web-based challenges.
Transfer of lncRNA UCA1 by hUCMSCs-derived exosomes protects against hypoxia/reoxygenation injury through impairing miR-143-targeted degradation of Bcl-2

Ischemia results in neuronal damage via alterations in gene transcription and protein expression. Long noncoding RNAs (LncRNAs) are pivotal in the regulation of target protein expression in hypoxia/reoxygenation (H/R). In this study, we observed the function of exosomes-carried lncRNA UCA1 in H/R-induced injury of cardiac microvascular endothelial cells (CMECs). In H/R cell model, CMECs were co-cultured with human umbilical cord mesenchymal stem cell-derived exosomes (hUCMSC-ex). The loss-of-function experiments were conducted to assess the effect of lncRNA UCA1 on H/R injury by assessing the biological behaviors of CMECs. The relationship among lncRNA UCA1, miR-143 and Bcl-2 were verified. An ischemia-reperfusion (I/R) rat model was established. Then hUCMSC-ex was injected into I/R rats to identify its effects on apoptosis and autophagy. Functional rescue experiments were performed to verify the sponge system. In vitro and in vivo experiments showed that hUCMSC-ex protected I/R rats and H/R CMECs against injury. Silencing UCA1 in hUCMSC-ex or miR-143 overexpression aggravated H/R injury in CMECs. LncRNA UCA1 competitively bound to miR-143 to upregulate Bcl-2. And hUCMSCs-ex/si-UCA1+inhi-miR-143 treatment protected CMECs against H/R injury and inhibited hyperautophagy. Together, hUCMSC-ex-derived lncRNA UCA1 alleviates H/R injury through the miR-143/Bcl-2/Beclin-1 axis. Hence, this study highlights a stem cell-based approach against I/R injury.
The role of electrochemotherapy with intratumoral bleomycin for early tongue carcinoma

Abstract Background The role of electrochemotherapy (ECT) using intratumoral bleomycin and electroporation as a first line treatment for oral tongue carcinoma has not been defined. Aims/Objectives To evaluate the method of ECT in oral tongue carcinoma. Material and Methods Twenty-one successive patients with primary T1-T2 oral cancer predominantly of the oral tongue underwent either ECT (test; n = 9), or standard surgical resection and reconstruction (control; n = 12). Outcome variables were: local recurrence rates, 10-year-survival, adverse events, treatment cost, and quality of life. Results The 10-year local recurrence rate (44.4%) was higher and the tumour-specific survival rate (55.6%) was lower in the ECT group compared to the control group (17% and 91.6%, respectively). Postoperative haemorrhage, dysphagia, and pain were more frequent in ECT patients, treatment time was shorter, but treatment cost was higher. Quality of life was not improved by ECT. Conclusions and Significance Our results indicate that ECT seems not as suitable for the treatment of early tongue cancer as it is for neoplastic and metastatic skin lesions and less favourable than standard surgical therapy.
Blood cancer health disparities in the United States Hispanic population

Cancer is a challenging, multifaceted disease that involves a combination of biological and nonbiological factors. Aside from COVID-19, cancer is the second leading cause of death in the United States and the first among Hispanic Americans. The Hispanic population is the largest minority group in the United States, which is rapidly growing in size. Unfortunately, U.S. Hispanics and other minority groups experience many different health disparities, resulting in poor survival outcomes and a reduced quality of life. Factors such as genomic mutations, lower socioeconomic status, lack of education, reduced access to health care, comorbidities, and environmental factors all contribute to these health-care inequalities. In the context of blood cancer health disparities, Hispanic patients are often diagnosed at a younger age and have worse outcomes compared with non-Hispanic individuals. In this commentary, we highlight the existing knowledge about cancer health disparities in the Hispanic population, with a focus on chronic and acute leukemia. In our experience at the U.S./Mexican border, analysis of several different blood cancers demonstrated that younger Hispanic patients with acute lymphoid or myeloid leukemia have higher incidence rates and worse prognoses. A combined approach, involving improved health-care access and better knowledge of the underlying factors, will allow for more timely diagnoses and the development of intervention strategies aimed at reducing or eliminating the disparities.
Engine Performance and Exhaust Emission Tests of Sulfate Turpentine and No:2 Diesel Fuel Blend

Abstract: Environmentally friendly, biobased fuel additives become more important when environmental concerns all around the world are considered. In this study, sulfate turpentine is investigated as a candidate diesel fuel additive. Engine performance tests were conducted on a 53 kW, 4000 rpm Peugeot XD 3P 157 type diesel engine for 3:97 turpentine and No:2 diesel fuel blend and similar results to No:2 diesel fuel were obtained. Significant reduction in exhaust emissions were observed as a result of using turpentine and No:2 diesel fuel blend.
Shade, light, and stream temperature responses to riparian thinning in second-growth redwood forests of northern California

Resource managers in the Pacific Northwest (USA) actively thin second-growth forests to accelerate the development of late-successional conditions and seek to expand these restoration thinning treatments into riparian zones. Riparian forest thinning, however, may impact stream temperatures–a key water quality parameter often regulated to protect stream habitat and aquatic organisms. To better understand the effects of riparian thinning on shade, light, and stream temperature, we employed a manipulative field experiment following a replicated Before-After-Control-Impact (BACI) design in three watersheds in the redwood forests of northern California, USA. Thinning treatments were intended to reduce canopy closure or basal area within the riparian zone by up to 50% on both sides of the stream channel along a 100–200 m stream reach. We found that responses to thinning ranged widely depending on the intensity of thinning treatments. In the watersheds with more intensive treatments, thinning reduced shade, increased light, and altered stream thermal regimes in thinned and downstream reaches. Thinning shifted thermal regimes by increasing maximum temperatures, thermal variability, and the frequency and duration of elevated temperatures. These thermal responses occurred primarily during summer but also extended into spring and fall. Longitudinal profiles indicated that increases in temperature associated with thinning frequently persisted downstream, but downstream effects depended on the magnitude of upstream temperature increases. Model selection analyses indicated that local changes in shade as well as upstream thermal conditions and proximity to upstream treatments explained variation in stream temperature responses to thinning. In contrast, in the study watershed with less intensive thinning, smaller changes in shade and light resulted in minimal stream temperature responses. Collectively, our data shed new light on the stream thermal responses to riparian thinning. These results provide relevant information for managers considering thinning as a viable restoration strategy for second-growth riparian forests.
The mosaic mtr locus as major genetic determinant of azithromycin resistance of Neisseria gonorrhoeae, Germany, 2018.

Within the German Gonococcal Resistance Network (GORENET) Neisseria gonorrhoeae (NG) sample collection, azithromycin-resistant NG isolates increased from 4.3% in 2016 to 9.2% in 2018. We aim to understand this observed increase using whole genome sequencing of NG isolates combined with epidemiological and clinical data. Reduced susceptibility to azithromycin in 2018 was predominately clonal (NG-MAST G12302) and could mainly be accounted to the recently described mosaic-like mtr locus. Our data suggest that, together with horizontal gene transfer of resistance determinants and well-established point mutations, international spread of resistant lineages plays a major role regarding azithromycin resistance in Germany.
The prognostic value of comorbidity for the severity of COVID-19: A systematic review and meta-analysis study

Background and objectives With the increase in the number of COVID-19 infections, the global health apparatus is facing insufficient resources. The main objective of the current study is to provide additional data regarding the clinical characteristics of the patients diagnosed with COVID-19, and in particular to analyze the factors associated with disease severity, lack of improvement, and mortality. Methods 102 studies were included in the present meta-analysis, all of which were published before September 24, 2020. The studies were found by searching a number of databases, including Scopus, MEDLINE, Web of Science, and Embase. We performed a thorough search from early February until September 24. The selected papers were evaluated and analyzed using Stata software application version 14. Results Ultimately, 102 papers were selected for this meta- analysis, covering 121,437 infected patients. The mean age of the patients was 58.42 years. The results indicate a prevalence of 79.26% for fever (95% CI: 74.98–83.26; I2 = 97.35%), 60.70% for cough (95% CI: 56.91–64.43; I2 = 94.98%), 33.21% for fatigue or myalgia (95% CI: 28.86–37.70; I2 = 96.12%), 31.30% for dyspnea (95% CI: 26.14–36.69; I2 = 97.67%), and 10.65% for diarrhea (95% CI: 8.26–13.27; I2 = 94.20%). The prevalence for the most common comorbidities was 28.30% for hypertension (95% CI: 23.66–33.18; I2 = 99.58%), 14.29% for diabetes (95% CI: 11.88–16.87; I2 = 99.10%), 12.30% for cardiovascular diseases (95% CI: 9.59–15.27; I2 = 99.33%), and 5.19% for chronic kidney disease (95% CI: 3.95–6.58; I2 = 96.42%). Conclusions We evaluated the prevalence of some of the most important comorbidities in COVID-19 patients, indicating that some underlying disorders, including hypertension, diabetes, cardiovascular diseases, and chronic kidney disease, can be considered as risk factors for patients with COVID-19 infection. Furthermore, the results show that an elderly male with underlying diseases is more likely to have severe COVID-19.
Immunotherapy for the treatment of colorectal cancer

Immune checkpoint inhibition (ICI) has transformed the management of metastatic colorectal cancer (mCRC) with mismatch‐repair deficiency (dMMR) and microsatellite instability (MSI‐H), though this constitutes on average less than 5% of mCRC, and ICI is ineffective in preserved MMR/microsatellite stable disease (pMMR/MSS). Here we review the efficacy of ICI in dMMR/MSI‐H mCRC, poor response to ICI in pMMR/MSS mCRC, role for ICI in locally advanced disease, biomarkers of response, novel immunotherapies, and future directions in targeting resistance mechanisms.
Pressure Calibration for Multi-Anvil Apparatuses in High-Pressure Earth Science

Accurate characterization of the pressure and temperature environment in high-pressure apparatuses is of essential importance when we apply laboratory data to the study of the Earth's interior. Difficulties in pressure determination of multi-anvil apparatuses are summarized. The First International Pressure Calibration Workshop is briefly reported with the Preliminary International Pressure Scale (PIPS-97). Some prospects on the pressure scale at high-temperatures for the multi-anvil apparatuses are discussed.