Miracle-dz/UniFAR-FTUs huggingface dataset:
Vitamin D Status and Redefining Serum PTH Reference Range in the Elderly

Busuttil and Frauman (1) have recently studied the expression of the TSH receptor (TSH-R) in all four chambers of the human heart, and have failed to confirm using RT-PCR earlier findings of TSH-R transcript in this organ (2, 3). We suggest that this report, rather than confirming an absence of TSH-R in the heart, is better interpreted as supporting a scarcity of the transcript in cardiac muscle per se. In our earlier report of TSH-R expression in the porcine heart (4), we did detect TSH-R transcript by RT-PCR with primers spanning exons 9 and 10 of the full-length receptor, but expression levels varied regionally. Although essentially undetectable by single-round PCR in the left ventricular myocardium and in purified ventricular cardiocytes (in support of the study by Busuttil and Frauman), definitive TSH-R expression was observed in the right atrium and in purified atrial cardiocytes. However, the highest expression levels were observed in isolated coronary arteries and in epicardial adipose tissue, neither of which was examined in the study of human cardiac tissues (1). All PCR products in our study were confirmed as TSH-R by DNA sequencing. The differential pattern of expression of TSH-R in porcine cardiac tissues and its reproducibility in two different pig hearts argues strongly against “illegitimate transcription” (4) as an explanation of our results, as does the recent detection of TSH-R transcript in the salmon heart using a similar PCR technique (5). We suggest that our differences from the study by Busuttil and Frauman (1) regarding TSH-R transcript in cardiac muscle tissue reflect the difficulties inherent in detecting transcripts of low abundance, namely the requirement for high-quality RNA prepared from fresh tissue, and for optimized primers and optimal PCR amplification conditions. In this context, we note that our RT-PCR studies were performed with poly A RNA (not total RNA) extracted from porcine cardiac tissues that were flash frozen in liquid nitrogen. It remains to be determined whether TSH-R transcripts in the heart may have functional significance. Some evidence to this effect may be found in our subsequent studies with TSH-R expression and TSH activation of cAMP in human coronary artery smooth muscle cells in culture (6). However, a complete picture of TSH-R function in cardiac physiology will require additional studies to elucidate which specific cell types express this receptor, and how its expression might be altered in thyroid or cardiac diseases, as earlier suggested (7).
AENDO January 41/1

Ganz, Michael B. , and Allen Seftel. Glucose-induced changes in protein kinase C and nitric oxide are prevented by vitamin E. Am. J. Physiol. Endocrinol. Metab. 278: E146– E152, 2000. —Changes in activity or expression of protein kinase C (PKC), reactive oxygen products, and nitric oxide (NO) may account for the alteration in cell behavior seen in diabetes. These changes have been proposed to be part of the pathophysiology of erectile dysfunction. We sought to ascertain if corpus cavernosal vascular smooth muscle cells (CCSMC) grown in a high glucose milieu exhibit changes in the activity and expression of PKC isoforms, NO, and reactive oxygen products and to find out if these changes are prevented by a-tocopherol. Rat CCSMC were grown in 5, 15, and 30 mM glucose concentrations for 3, 7, and 14 days. PKC isoform expression was assayed with isoform-specific antibodies. In CCSMCs grown in 30 mM glucose for 2-wk, PKC-b2isoform was upregulated (n 5 4; P , 0.01), whereas the expression of a-, d-, e-, and b1-isoforms was unchanged. NO as measured by nitrate-to-nitrite ratio was greatly diminished at 14 days in 30 mM (n 5 4; P , 0.002) compared with 5 mM glucose. Reactive oxygen products were upregulated at 14 days when they were assayed by the fluorescent probe dichlorofluorescein diacetate bis(acetoxy-methyl) (DCFHDA) (n 5 5; P , 0.01). When these same cells were exposed to a-tocopherol for 14 days, there was a reduction of PKC-b2 (57.8%; P , 0.01; n 5 4) and a reduction in reactive oxygen product formation (71.1%; P , 0.001; n 5 4), along with an increase in nitrate-to-nitrite ratio (43.9%; P , 0.01, n 5 4). These results suggest that there may be an interrelationship between PKC, NO, and reactive oxygen product formation in CCSMC exposed to a high glucose environment.
Numerical Analysis and Optimization of CH 3 NH 3 PbI 3-x CI x Based Perovskite Solar Cells Düzce University Journal of Science & Technology

Due to unique properties of perovskite materials, the solar cells technologies based on those materials rapidly advance to the maximum theoretical conversion efficiency of about 32 %. This study reports the simulation results of CH 3 NH 3 PbI 3-x CI x based perovskite solar cells using SCAPS-1D software. ZnO is used as common electron transfer medium (ETM), whereas Cu 2 O, CuI and CuO materials are separately used for hole transfer medium (HTM) each time. The cell basic parameters (V oc , J sc , FF and efficiency) are simulated at various conditions. CuO is found to be the best HTM material, whereas the maximum efficiency of ̴26.8 % is obtained at 0.55 µm thickness of CH 3 NH 3 PbI 3-x CI x material with a donor atom density of about 10 17 cm -3 .
Prevalence of Malocclusion and Occlusal Traits in Children with Autism Spectrum Disorders

Background: The purpose of this cross-sectional study was to evaluate the prevalence of malocclusion in children with autism spectrum disorders (ASDs) and to determine the most common occlusal traits. Materials and Methods: The present cross-sectional study was conducted among 7–15 years old children with ASDs and randomly selected healthy children with the same demographic characteristics. Molar relationship, lip incompetence, overbite, overjet, midline deviation, crossbite, and crowding/spacing were recorded. A descriptive analysis was performed for all variables. A comparison of the presence or absence of malocclusion traits between children with and without ASDs was assessed using the chi-square test. Univariate and multivariate logistic regressions were used to calculate odds ratio (OR) and 95% confidence intervals (95% CI) to assay various parameters between autism and non-autism group. Results: A total of 96 patients were assessed, 47 patients in the ASD group, and 49 in the control (non-ASD) group. The results showed no significant difference between the ASD and control groups in terms of the overall prevalence of malocclusion (P>0.05). However, the prevalence of increased overjet and Class II molar relationship was significantly higher in the ASD group compared to the control group (P=0.03). Patients in the control group showed a higher prevalence of midline deviation (P=0.001). Conclusion: Despite a higher prevalence of overjet and Class II molar relationship in children with ASDs, the prevalence of malocclusion was not higher in this group of patients.
A. (2017). Assessing the impact of informal governance on political innovation. Public Management Review , 19 (1), 90-107.

The aim of this article is to examine the role played by ‘informal governance’ in shaping political innovation. Informal governance can be defined as a means of decision-making that is un-codified, non-institutional and where social relationships play crucial roles. This article explores the impact of informal governance on three dimensions of political innovation innovations in polity (institutions), politics (process) and policy (outcomes). It argues that an analysis of informal governance is essential if we are to fully understand how political innovation occurs. Research evidence suggest that even when formal structures and procedures are weak, political innovation can still thrive.
DMD048272 958..965

Organic anion-transporting polypeptides (OATPs) are multispecific transporters mediating the uptake of endogenous compounds and xenobiotics in tissues that are important for drug absorption and elimination, including the intestine and liver. Silymarin is a popular herbal supplement often used by patients with chronic liver disease; higher oral doses than those customarily used (140 mg three times/ day) are being evaluated clinically. The present study examined the effect of silymarin flavonolignans on OATP1B1-, OATP1B3-, and OATP2B1-mediated transport in cell lines stably expressing these transporters and in human hepatocytes. In overexpressing cell lines, OATP1B1and OATP1B3-mediated estradiol-17b-glucuronide uptake and OATP2B1-mediated estrone-3-sulfate uptake were inhibited by most of the silymarin flavonolignans investigated. OATP1B1-, OATP1B3-, and OATP2B1-mediated substrate transport was inhibited efficiently by silymarin (IC50 values of 1.3, 2.2 and 0.3mM, respectively), silybin A (IC50 values of 9.7, 2.7 and 4.5 mM, respectively), silybin B (IC50 values of 8.5, 5.0 and 0.8 mM, respectively), and silychristin (IC50 values of 9.0, 36.4, and 3.6 mM, respectively). Furthermore, silymarin, silybin A, and silybin B (100 mM) significantly inhibited OATP-mediated estradiol-17b-glucuronide and rosuvastatin uptake into human hepatocytes. Calculation of the maximal unbound portal vein concentrations/IC50 values indicated a low risk for silymarin-drug interactions in hepatic uptake with a customary silymarin dose. The extent of silymarin-drug interactions depends on OATP isoform specificity and concentrations of flavonolignans at the site of drug transport. Higher than customary doses of silymarin, or formulations with improved bioavailability, may increase the risk of flavonolignan interactions with OATP substrates in patients.
The clinical impact of preincubation of blood cultures at 37 ° C 1

10 11 *Corresponding author: 12 PDJ Sturm 13 Radboud University Nijmegen Medical Centre 14 Department of Medical Microbiology 15 Geert Grooteplein-Zuid 10 16 6525 GA Nijmegen, The Netherlands 17 Telephone: 0031-243614356 18 Fax: 0031-243540216 19 Email: P.Sturm@mmb.umcn. nl 20 Copyright © 2010, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved. J. Clin. Microbiol. doi:10.1128/JCM.00552-10 JCM Accepts, published online ahead of print on 10 November 2010
University of Birmingham Reconsolidation of appetitive memories for both natural and drug reinforcement is dependent on B-adrenergic receptors

We have investigated the neurochemical mechanisms of memory reconsolidation and, in particular, the functional requirement for intracellular mechanisms initiated by (cid:1) -adrenergic signaling. We show that propranolol, given in conjunction with a memory reactivation session, can specifically disrupt the conditioned reinforcing properties of a previously appetitively reinforced conditioned stimulus (CS), whether the stimulus had been associated with self-administered cocaine or with sucrose. These data show that memories for both drug and nondrug CS–US associations are dependent on (cid:1) -adrenergic receptor-mediated signaling for their reconsolidation, with implications for the potential development of a novel treatment for drug addiction and some forms of obesity. The neurochemical mechanisms underlying memory reconsoli- dation—the process hypothesized to occur following the reactivation or retrieval of a fully consolidated memory upon re- exposure to conditioned stimuli (Nader 2003; Dudai and Eisen-berg 2004)—have become increasingly investigated, in part because of the emergence of the view that disrupting memory reconsolidation might be exploited to treat neuropsychiatric dis- orders based upon the existence of maladaptive memories (e.g., Debiec and LeDoux 2006). Adrenergic signaling is implicated in both memory consolidation and reconsolidation; the administration of adrenaline en- hances memory consolidation in aversive and appetitive tasks in animals and humans (Gold Liang Stern- berg Introini-Collison McGaugh and the administration of adrenergic receptor antagonists induces memory deficits in tasks including inhibitory avoidance taste and odor–reward associations
Highand di¡erential viral infection rateswithin bacterial ‘morphopopulations’ ina shallowsand pit lake (LacdeCre¤ teil, France)

Highand di¡erential viral infection rateswithin bacterial ‘morphopopulations’ ina shallowsand pit lake (LacdeCre¤ teil, France) A.S. Pradeep Ram, Bashir Arnous, Michael Danger, Jean-François Carrias, Gérard Lacroix & Télesphore Sime-Ngando Clermont Université, Blaise Pascal, Clermont-Ferrand, France; Laboratoire Microorganismes: Génome et Environnement, CNRS, UMR 6023, Aubière, France; Laboratoire Bioemco, Biogéochimie et Ecologie des Milieux Continentaux, UMR 7618 (Université Paris 6, CNRS, INRA, ENS), Ecole Normale Supérieure, Paris, France; and Laboratoire des Interactions Ecotoxicologie, Biodiversité, Ecosystèmes LIEBE, Université, Paul Verlaine – Metz, CNRS UMR 7146, Metz, France
STUDIES ON TUBERCLE BACILLUS-MONOCYTE RELATIONSHIP* I. QUANYITA~ ANALYSIS OF EFFECT OF SERU~ OF ANIMALS

The role of mononudear phagocytes in the destruction of human tubercle bacilli in the natively resistant animal has been reported by Lewis and Sanderson (1). Histological and cultural studies by Lurie (2) of the fate of tubercle bacilli contained in normal and immune phagocytes cultivated in the anterior chambers of the eyes of normal rabbits have suggested a greater capacity of the mononuclear phagocytes of the tuberculous animal to inhibit multiplication of tubercle bacilli. The recent experiments by Surer (3) appear to confirm Lurie's conclusions that the mononudear cells of immune animals are peculiarly and specially endowed with the capacity for handling virulent tubercle bacilli. Investigations by Mackaness (4), on the other hand, revealed no significant differences in the behavior of normal and immune monocytes toward virulent strains of Mycobacterium tuberculosis.
OPTH_A_294710 445..451

Medical School of the University of the West of Santa Catarina (Universidade do Oeste de Santa Catarina – UNOESC), Joaçaba, Santa Catarina, Brazil Objective: To assess whether the non-contact air-puff tonometer (NCT) is an appropriate alternative to the Goldmann applanation tonometer (GAT) for measuring intraocular pressure (IOP). Patients and Methods: An observational, cross-sectional, and comparative study with a quantitative approach was carried out. Two techniques for IOP measurements using the standard GAT and the NCT were compared. A total of 180 eyes from 90 patients were included in the study. Results: The total mean IOP according to NCT measurements was 14.12 mmHg, and the total mean IOP according to the GAT was 12.98 mmHg; these values were significantly different (p=0.0018). When dividing the participants into three groups according to the measurement range obtained and comparing the mean NCT and GAT measurements in each group, in Group 1 (10–15 mmHg), no statistically significant difference was found between the means of the two tonometers (p=0.3100), a difference was observed between Group 2 (16–19 mmHg) and Group 3 (20 mmHg or more) (p<0.001). When dividing the participants by age group, the means obtained by the two tonometers also differed significantly between Group 4 (40–59 years) and Group 5 (60 years or more) (p<0.0001). In all groups, the mean measurements by the NCT were higher than those by the GAT. Conclusion: The NCT presented an approximate mean of the measures with the GAT in group 1 but was overestimated in the measurements of the groups 2 and 3.
(2019). Recipients Receiving Better HLA-Matched Hematopoietic Cell Transplantation Grafts, Uncovered by a Novel HLA Typing Method, Have Superior Survival: A Retrospective Study. Biology of Blood and Marrow Transplantation , 25 (3), 443-450.

transplantation survival and fewer post-transplant complications. Limitations in typing technolo- gies used for the hyperpolymorphic HLA genes have meant that variations outside of the antigen recognition domain (ARD) have not been previously characterized in HCT. Our aim was to explore the extent of diversity out- side of the ARD and determine the impact of this diversity on transplant outcome. Eight hundred ninety-one VUD-HCT donors and their recipients transplanted for a hematologic malignancy in the United Kingdom were ret- rospectively HLA typed at an ultra-high resolution (UHR) for HLA-A, -B, -C, -DRB1, -DQB1, and -DPB1 using next-generation sequencing technology. Matching was determined at full gene level for HLA class I and at a coding DNA sequence level for HLA class II genes. The HLA matching status changed in 29.1% of pairs after UHR HLA typing. The 12/12 UHR HLA matched patients had signi ﬁ cantly improved 5-year overall survival when compared with those believed to be 12/12 HLA matches based on their original HLA typing but were found to be mismatched after UHR HLA typing (54.8% versus 30.1%, P =.022). Survival was also signi ﬁ cantly better in 12/12 UHR HLA- matched patients when compared with those with any degree of mismatch at this level of resolution (55.1% versus 40.1%, P =.005). This study shows that better HLA matching, found when typing is done at UHR that includes exons outside of the ARD, introns, and untranslated regions, can signi ﬁ cantly improve outcomes for recipients of a VUD-HCT for a hematologic malignancy and should be prospectively performed at donor selection. Blood and Marrow Transplantation. access the CC BY-NC-ND license. (http://creativecommons.org/licenses/by-nc-nd/4.0/)
are the barriers and facilitators for women with depressive symptoms seeking help in the postnatal period? A qualitative systematic

What review British Abstract Background: Perinatal mental health problems affect approximately 20% of women, the most common condition being postnatal depression; however many women do not seek help. Aims: To identify and synthesise evidence on the barriers and facilitators to help-seeking in women with depressive symptoms in the postnatal period. Methods: A qualitative systematic review was conducted using electronic databases and pre-determined eligibility criteria. Findings: Thematic synthesis of the included studies (n=4) identified the following themes: the influence of healthcare services, the influence of others and the influence of women themselves. Help-seeking was shaped by women’s ability to recognise their symptoms, the reactions (experienced or anticipated) of others and the organisation of services. Conclusion: An improved interface between maternity and mental health services and enhanced healthcare professional interactions are needed. However meaningful change may require empowering women's self-assessment and public health messages to improve understanding of postnatal depression.
Prevention of patient falls in University Hospital

Falls are responsible for considerable morbidity, immobility, and mortality among older persons. In healthcare facilities, patient falls have been a major contributing factor associated with patient injuries that result in increased length of the hospital stay and costs (Wayland et al, 2010). From a historical standpoint, nursing’s concern for patient safety is nothing new. As early as 1859, Florence Nightingale observed that there were strikingly fewer falls when all the patients were in a single open ward and could be observed. Not surprisingly, she advocated the extensive use of glass to improve patient observation. Miss Nightingale’s suggestion about the use of glass is one example of how we can eliminate one obstacle, inadequate observation, to provide for better patient safety (Kulikowski, 1979). Falls have many different causes, and several risk factors that predispose patients to falls have been identified.
Black: Exploring Racial Label Preferences of African Americans and Afro-Caribbeans in the United States

People of African descent living in the United States subscribe to a variety of racial self-identification labels. Given their historical and political meaning, ‘Black’ or ‘African American’ have been the two most common self-identification terms used by this population yet increasing immigration rates among people of African descent from the Caribbean have diversified the racial label preferences. Past research suggests age, gender, education, and region are factors that influence racial identification preferences for Black people in the United States. This study contributes by examining how experiences of discrimination and ethnicity/nativity impact racial self-labeling among people of African descent living in the United States. Analyzing the National Survey of American Life, I find that experiences with major forms of discrimination and nativity condition racial labeling preferences, and differently for those born in the US and those with ties to the Caribbean. Additionally, these findings indicate that age, household income, educational attainment and region significantly predict racial identification labels. This study encourages scholars to think critically about the racial labels they use to speak about African descendants living in the United States in order to more accurately disentangle intra-racial group differences relating to social mobility, racism, and racial inequality.
OP-SCAN130037 699..704

David S. Chester, Naomi I. Eisenberger, Richard S. Pond, Jr, Stephanie B. Richman, Brad J. Bushman, and C. Nathan DeWall Department of Psychology, University of Kentucky, Lexington, KY, 40506, USA, Department of Psychology, University of California, Los Angeles, CA, 90095, USA, School of Communication, The Ohio State University, Columbus, OH, 43210, USA, and Communication Sciences, VU University, Amsterdam, 1080 VA, The Netherlands
TCRM_A_234377 1243..1255

1Institute of Applied Health Research, University of Birmingham, Birmingham, UK; 2University Hospitals Birmingham, Birmingham, UK Abstract: This review summarizes the current research and outlooks regarding the obstacles to diagnosing and treating early alpha-1-antitrypsin deficiency (AATD). It draws on prior systematic reviews and expert surveys to discover precisely what difficulties exist in early diagnosis and treatment of AATD and elucidate potential solutions to ease these difficulties. The perceived rarity of AATD may translate to a condition poorly understood by primary care physicians, and even many respiratory physicians, which results in opportunities for diagnosis being missed, especially in mild or asymptomatic patients. There are diagnostic techniques involving biomarkers and home testing methods which could improve the rate of early diagnosis. With respect to treatment, AATD involves treating two separate pathologies, lung disease and liver disease. The only specific AATD treatment, augmentation therapy, has proven ability in treating lung disease but not liver disease. Alpha-1-antitrypsin (AAT) synthesized in the liver can form damaging polymers that also result in reduced circulating AAT levels and, whilst liver transplantation is used to effectively treat AATD, it is inappropriate in early disease. Novel therapeutic areas such as gene editing and increasing autophagy are therefore being researched as future treatments. Ultimately, diagnosis and treatment are intrinsically linked in AATD, with earlier diagnosis leading to better treatment options and thus better patient outcomes.
-triples, partial $*$ -isomorphisms and Morita equivalence

Let $B$ and $C$ be two $AW ^{*}$ -subalgebras of an $AW ^{*}$ -algebra $A$ . In this talk, we describe the relative position of $B$ and $C$ in $A$ (e.g., Morita equivalence, etc.) in terms of $AW ^{*}$ -subtriples of $A$ , the normalizer of $B$ and $C$ in $A$ , or partial $*- \mathrm{i}\mathrm{s}\mathrm{o}\mathrm{m}\mathrm{o}\mathrm{r}\mathrm{p}\underline{\mathrm{h}\mathrm{i}}\mathrm{s}\mathrm{m}\mathrm{s}$ between $B$ and $C$ (the deﬁnitions will be given below). Then, under a stronger assumption of $B$ and $C$ being monotone complete, we show that the set of these $AW ^{*}$ -subtriples is embedded naturally in an inverse semigroup associated with $B$ and $C$ . The key idea is to regard $AW ^{*}$ -algebras and $AW ^{*}$ -triples as a generalization of projections and partial isometries.