Miracle-dz/UniFAR-FTUs huggingface dataset:
Connecting the Role of the Information Technology Function to its Contribution to the Organization

ABSTRACT We investigate whether the information technology (IT) function’s competence and role affect organizational ambidexterity. We first hypothesize that IT function competence is positively related to organizational ambidexterity. Following this, we suggest that the role of the IT function moderates the aforementioned relationship. We test our hypotheses with a matched pair sample of business managers and IT managers. Our results show that IT function competence positively influences organizational ambidexterity. Furthermore, this relationship is stronger when the IT function aims to be an active business partner or aims to reduce architectural complexity. Our study contributes to research on the IT function and IT value.
Caractérisation de la pathogenèse associée à l'infection par le métapneumovirus humain (HMPV) et évaluation de modalités prophylactiques et thérapeutiques

The human metapneumovirus (hMPV) is a newly-described viral pathogen first reported in the Netherlands in 2001. HMPV is associated with acute respiratory tract infections in all age groups with more severe diseases such as bronchiolitis/bronchitis and pneumonia occurring in young children, elderly individuals and immunocompromised hosts. Before we started this project, no experimental models had been developed, the pathogenesis was not exhaustively described and no vaccines, chemotherapeutic agents, or antibody preparations had been approved for the prevention or treatment of hMPV infections in humans or even studied in vivo. The aim of this project was to develop an experimental animal model for hMPV infection to : 1-characterize the pathogenesis associated with this viral infection and 2-evaluate novel therapeutic or prophylactic modalities. The Balb/c mice and cotton rat are both permissive to hMPV infection. They support efficient viral replication in the lower respiratory tract and the infection is associated with significant lung inflammation. However, Balb/c mice are more susceptible to the infection, as we observe clinical symptoms such as weight loss and breathing difficulties characterized by significant airways obstruction and hyperresponsiveness only in this animal model. Ribavirin has shown antiviral properties against hMPV and significantly reduced viral replication and pulmonary inflammation. Immunizations with inactivated hMPV mixed with adjuvant induced a severe pulmonary disease following intra-nasal infection, as it has already been observed with other paramyxoviruses. Subunit vaccines seem safer preparations to pursue the development of hMPV vaccines. The Balb/c mice and cotton rat experimental models are great tools to better understand hMPV pathogenesis and also to evaluate different therapeutic and prophylactic modalities.
Inflammatory signaling in skeletal muscle cell growth

This thesis examines the potential beneficial role of inflammation in skeletal muscle tissue. This work establishes cyclooxygenase pathway derived prostaglandins as key anabolic signalling molecules regulating skeletal muscle cell growth and examines changes in circulating inflammatory lipid mediators and intramuscular anabolic signaling in response to acute resistance exercise in humans.
Evaluation of Histopathological Effects of Contaminated Unexpired Gentamicin Injections on the Kidney Tissues of Juvenile Wistar Rats

The histo-pathological effects of contaminated gentamicin injections on the kidney tissues of juvenile wistar rats have been investigated using standard microbiological and histo-pathological techniques. Freeze-dried and heat fixed thin sections of wistar rats’ kidney were observed under the microscope using x10, x40 and x100 magnifications. The results revealed marked necrosis and erosion of proximal borders especially the focal epithelium of proximal convoluted tubules (PCT) of the kidney, with the retention of the cytoarchitecture. Plasmolysis was observed in the epithelial cells of the distal convoluted tubules (DCT) when treated with contaminated unexpired gentamicin injection sample as compared with control. Glomerular hypoplasia and fibrosis of the Bowman’s space occurred in the kidney when compared with the control. Also medulla interstitial oedema leading to focal tubular fibrosis as a result of microbial activity was observed when compared with control. Interstitial hemorrhage which led to complete tubular necrosis with loss of defined tubular cyto-architecture was observed. This effect made the tissue fibrous, resulting in a nonfunctional or shrunken kidney as compared to control. Results obtained from this work have raised serious health concerns, considering the risk posed by contaminated drugs on patients.
Costs and Benefits of a Mature First-Generation Loblolly Pine Tree Improvement Program

First-generation tree improvement programs with loblolly pine (Pinus taeda L.) are now reaching maturity. Yields from first generation seeds orchards in the North Carolina State University - Industry Cooperative Tree Improvement Program are now great enough to allow most members to meet all of their regeneration needs with improved stock. Progeny test measurement is a major activity of the cooperative, with the final-first generation progeny tests established in 1983. Final crop gains on 25 year rotations from one generation of loblolly pine tree improvement are estimated to be as high as 7% in height (site index), 12% in cubic foot volume, and 32% in harvest value. Tree improvement continues to be an attractive investment opportunity. Rates of return for investments in loblolly pine tree improvement depend on seed orchard yields, but appear to be on the order of 17 to 19% after taxes. 27 references.
Additional Elements of Value for Health Technology Assessment Decisions

Antimicrobial resistance (AMR) occurs when microorganisms such as bacteria, viruses, fungi and parasites change in ways that render the medications used to cure the infections they cause ineffective. Without new antibiotics, more patients will die from previously treatable infections. However, a key issue is how antibiotics can be appropriately assessed, particularly by payers and/or health technology assessment (HTA) bodies, to take account of AMR and reflect the full benefit they provide to patients and society. This Briefing discusses 10 elements of value which can be split into two groups - four relevant benefits typically included in HTA, and six other types of benefits not traditionally included. These were discussed at a multi-country, multi-disciplinary, multi-stakeholder Value Forum. Participants at the Forum also offered a number of valuable insights into how further work could be approached in order to maximise both its practicality and its potential policy impact. These are summarised in the Briefing. A two page summary of the briefing, written by Dr Chris Henshall and Professor Adrian Towse is available [here]( https://www.ohe.org/sites/default/files/Final%202%20Page%20Briefing%20AMR%20and%20HTA.pdf). ​
The Biomechanical, Physiological, and Cognitive Effects of Active Workstations and Utilizing Anthropometric Data to Improve the Usability

The benefits of a physically active lifestyle are well known, such as reducing the risks of developing type 2 diabetes, cardiovascular diseases, obesity, and some cancer types. However, many adults in high-income and developed countries work in sedentary jobs and report lack of time for physical activity. Studies have shown that prolonged sedentary behavior has been contributing significantly to the obesity epidemic. To prevent the spread of this, researchers have studied the use of active workstations to help accomplish light physical activity during office work. However, further investigation is needed to validate and better understand the use of active workstations. To further understand the possibility of using active workstations to improve health while maintaining work efficiency, this study investigates the physiological, biomechanical, and cognitive effects of using active workstations and discusses ways to improve the usability. The objectives include: (1) Investigating the ergonomic characteristics associated with using an under desk bike; (2) Comparing office related work performance while using an under desk bike to working in a seated position; (3) Comparing the energy expenditure of using active workstations (under desk bike, under desk elliptical trainer, and treadmill desk) to a seated or standing position; and (4) Comparing the muscle demands and joint kinematics of using active workstations to a seated or standing position. The findings for each research question are the following: (1) Recommended workstation measurements were proposed to accommodate 95% of the general U.S. population in using under desk bikes; (2) Under desk cycling had no significant effect on reading, logical reasoning, and phone call answering performances, but typing performance was significantly different, with a modest deterioration, compared to the traditional seated posture; (3) Using active workstations at light physical activity level could significantly increase energy expenditure by 67.5 (under desk bike) or up to 122.5 (treadmill desk) more kilocalories per hour compared to sitting or standing at the desk; and (4) Normative values regarding the muscle demands of eight lower extremity muscles and sagittal plane kinematic measures of the hip, knee, and ankle joints during the use of active workstations were determined to help guide clinical decision making related to lower extremity training and rehabilitation through active workstations. This study presents a range of topics on the physiological, biomechanical, and cognitive effects of using active workstations in a controlled lab setting to support the research on promoting light physical activity in the workplace. Future studies may conduct a longitudinal field study and include diverse populations to obtain more widely applicable results.
Assessment of Health Status of the Elderly and Pre-elderly at a Malaysia Elderly Care Centre

They were once called the baby boomers, born between 1946 to 1964, but now aged above 50 years old, they contribute to the increasing number of elderly population in Malaysia. Age classification for elderly people varies between countries but commonly pre-elderly people is defined as those aged between 50 to 64 years old while those aged more than 64 years old fall in elderly category. In Malaysia, it is projected that the elderly population will make up for 10% of the total population or 3.4 million by year 2020. Without effective and comprehensive healthcare system, the healthy lifestyle of this elderly population can be affected thus prohibiting them to return to their premorbid function. In this study, the health status of pre-elderly and elderly community residing at an Elderly Care Center in Selangor, Malaysia is assessed. In overall, 12 male occupants (4 elderly and 8 pre-elderly people) aged 50 years and above were interviewed to obtain data on their sociodemographic characteristics, medical history, hand functionality and hand strength measurements. The overall sample mean (standard deviation) age are 63 (8) years. The mean (standard deviation) for BMI is 20.26 (2.73) kg/m2 that falls in the normal category despite the visible nutritional deficiencies sign and symptoms on their physical body and facial. The mean (standard deviation) of handgrip measurements is 12.47 (6.69) kg, which is quite low but reasonable due to ageing factor.
Proposing a Secure Component-based-Application Logic and System’s Integration Testing Approach

Software engineering moved from traditional methods of software enterprise applications to com-ponent based development for distributed system’s applications. This new era has grown up forlast few years, with component-based methods, for design and rapid development of systems, butfact is that , deployment of all secure software features of technology into practical e-commercedistributed systems are higher rated target for intruders. Although most of research has been con-ducted on web application services that use a large share of the present software, but on the otherside Component Based Software in the middle tier ,which rapidly develops application logic, alsoopen security breaching opportunities . This research paper focus on a burning issue for researchersand scientists ,a weakest link in component based distributed system, logical attacks, that cannotbe detected with any intrusion detection system within the middle tier e-commerce distributed ap-plications. We proposed An Approach of Secure Designing application logic for distributed system,while dealing with logically vulnerability issue.
Juvenile coho salmon movement, growth and survival in a coastal basin of southern Oregon

Juvenile salmonids display highly variable spatial and temporal patterns of early dispersal that are influenced by density-dependent and density-independent factors. Although juvenile coho salmon (Oncorhynchus kisutch) movement patterns in streams and their relationship with body mass and growth have been examined in previous studies, most observations were limited to one season or one stream section. In this study, we monitored the movement of juvenile coho salmon throughout their period of residence in a coastal basin to identify prevalent dispersal strategies and their relationships with body mass, growth rates and survival. Our results revealed seasonally and spatially variable movement patterns. Juvenile coho salmon that dispersed to tidally affected reaches soon after emergence remained more mobile and expressed lower site fidelity than those individuals that remained in upper riverine reaches. We did not detect significantly different growth rates between sedentary and mobile individuals. Although a greater proportion of sedentary than mobile fish survived winter to emigrate from the creek in the spring, reach of residence at the onset of winter influenced these survival estimates. Hence, apparent summer-to-smolt survival for mobile individuals was greater than for sedentary fish in tidally influenced reaches, whereas in riverine reaches the sedentary strategy seemed to be favoured. Our research identified complex movement patterns that reflect phenotypic and life history variation, and underscores the importance of maintaining diverse freshwater and estuarine habitats that support juvenile coho salmon before marine migration.
Efficacy of Home Phototherapy in Neonatal Jaundice

Background: Jaundice is one of the most common problems in the neonatal period. Phototherapy is one of the most commonly used treatments for jaundice that can be used as a simple, practical home-based treatment. Hospitalization during the first days of birth to conduct phototherapy may result in problems like nosocomial infections and mother separation from the baby. Objectives: The aim of this study was to evaluate the efficacy of home phototherapy in the duration of treatment, mean bilirubin level, and complications. Methods: This clinical trial was performed on newborns with jaundice in Isfahan health centers. The sample was randomly divided into two groups: Phototherapy at home (32 patients) and phototherapy at the hospital (32 patients). A demographic questionnaire and a researcher-made checklist were used to collect data on variables such as the duration of treatment, the frequency of treatment failure, mean bilirubin, and phototherapy complications. Results: The mean duration of phototherapy in both groups was two days, which showed no significant difference (P = 0.32). The most common complication in both groups was skin rashes and restlessness, which also showed no significant between two groups (P > 0.05). There was no significant difference in terms of treatment failure (P = 0.246). Statistical tests also revealed that bilirubin reduction was the same in both groups. Conclusions: Home phototherapy can be suggested as a safe treatment with no complication to the patients.
Effect of varying levels of dietary ochratoxin A on the performance of broiler chickens

In the present study, the effect of varying levels of ochratoxin A (OTA) in the diet of broiler chickens was investigated. Day-old broiler chicks (200) were divided into 5 treatment groups (T1- control; T2 - T1 + 100 ppb OTA; T3 - T1 + 200 ppb OTA; T4 - T1 + 300 ppb OTA; and T5 - T1 + 400 ppb OTA. Each diet was fed to 4 replicated groups of 10 birds each from day- old to 42 days of age. During overall growth period (0-6 weeks), body weight gain (BWG) in T3, T4 and T5 was significantly lower than that of control group, whereas, the BWG of group T2 was statistically similar to that of control. OTA contamination at 200 ppb or higher resulted in significant reduction in BWG of broiler chicken. The overall feed intake (FI) in T5 was significantly lower than that of control group (T1). The FI in groups T2, T3 and T4 was statistically similar to that of control. OTA contamination at 200 ppb or higher resulted in poor FCR and thus deteriorating feed utilization efficiency in broilers. OTA at 200 ppb or at higher level resulted in increased mortality. Addition of 100 ppb OTA in diet did not produce any change in relative weights of liver, kidney and bursa of Fabricius, however, OTA contamination at 200 ppb or higher resulted in increased relative weights of liver and kidney; and reduced relative weight of bursa of Fabricius. Inclusion of 100 ppb OTA in diet did not produce any change in biochemical parameters of broiler chicken also. It was concluded that ochratoxin A up to 100 ppb in diet had no adverse effect on growth performance, organ weight and certain biochemical parameters in broiler chicken.
Genetics and biochemistry of "red cells" in Drosophila melanogaster.

Studies were made of the "red cells" strain of Drosophila melanogaster. "Red cells" flies are characterized by the presence of reddish pigment in certain fat cells. A genetic analysis revealed that the fat cells are pigmented only when flies are homozygous for two mutant genes. The two genes are 4.4 crossover units apart on the second chromosome. They were separated, maintained in separate stocks and recombined. When they were recombined the "red cells" phenotype was again produced as it is in the original stock. The two mutant genes have been named red cells (rc) and lysine (lys). With or without rc, the mutant gene, lys, causes flies which are homozygous for it to contain a greater quantity of the amino acid, lysine, than normal flies. In experiments with injection of radioactive lysine, over a period of eight hours normal flies converted thirteen times more lysine into carbon dioxide than did lys flies. The hypothesis was offered that lys is a mutation of a gene which is important in the degradation of lysine. The mutation causes an impairment in the processes by which lysine is degraded, therefore lysine tends to accumulate in the flies if they ingest more lysine than is required in protein synthesis. Attempts were made to localize the position of the step at which lys impairs the degradation of lysine.
The prevalence of painful diabetic neuropathy in 300 Moroccan diabetics

Painful diabetic neuropathy is a frequent complication of diabetes. Its diagnosis is clinical. Our goal is to determine the prevalence of painful diabetic neuropathy in this population. We also analyzed the relationship between this neuropathy and certain parameters, concerning the patient and his diabetes. It is a cross sectional study conducted at the department of endocrinology and internal medicine of Avicenne hospital Marrakech-Morocco, among a cohort of 300 diabetic outpatients. We used the DN4 questionnaire (Douleur Neuropathique en 4 questions), for diagnosis. The results showed a prevalence of 15%. In this study: advanced age, female gender, duration of diabetes greater than 10 years, and the lack of medical follow up were found to be statistically significant risk factors for painful diabetic neuropathy, in addition to some diabetes-related comorbidities such as hypertension, dyslipidemia, sedentary life style and diabetic retinopathy. Painful diabetic neuropathy remains undertreated, in fact 74% of our patients did not receive any specific treatment, knowing that the progress in developing effective and well-tolerated therapies has been disappointing.
Effect of teaching material based on mobile learning to learning outcomes of natural environment

Learning materials that are integrated with technology are currently being used. This study aims to determine the effect of mobile learning-based teaching materials on student learning outcomes in thematic learning in elementary schools. This study uses an experimental method with a 2x2 level treatment design, to answer the question of how the influence of mobile learning-based teaching materials for elementary schools. The results showed that there were significant changes to the learning outcomes of students after using mobile learning-based teaching materials, compared to using conventional teaching materials. Thus it can be concluded, that teaching materials based on mobile learning can affect the learning outcomes of elementary school students.
Tumor Suppressor P53 Gene Mutations Pattern Induced by Repeated Fried Palm Oil in Rats

The present study aimed to examine the presence of p53 gene mutations in white albino rats fed on repeated fried palm oil. Eighteen sexually mature male Albino rats were used throughout the experiment. Rats were divided randomly into three groups, 6 animals each, namely; control group (CO) which orally administered by distilled water (NO) group which fed on basal diet containing fresh pure palm oil (FO) group which fed on the basal diet containing repeated fried palm oil with a dose of 150 mL kg-1 diet. At the end of the experiment, liver samples were taken, kept at -80Â°C for genetic alteration studies. Results shows the presence of fifty eight base-pair substitutions mutations which include a total of twelve base pair substitutions arose at A:T base pairs, fourteen base pair substitutions arose at G:C base pairs, Eighteen base pair substitutions at T: A base pairs, fourteen base pair substitutions arose at C:G base pairs. Of the fifty eight substitutional mutations recorded, there were thirty one silent (same sense) mutations and twenty seven missense mutations which causing the substitution of amino acids.
Altered IL-2 and IL-10 serum levels in schizophrenic patients

Schizophrenia (SZ) is severe mental disorder and characterized by fundamental disturbances in thinking, perception and emotions. Immune deregulation has been postulated to be one of the mechanisms underlying the pathogenesis of schizophrenia. This study hypothesized that interleukins would have a link with schizophrenia patients. The serum IL-2 and IL-10 levels were examined by enzymelinked immunosorbent assay (ELISA) in schizophrenia patients (n=60) and healthy controls (n = 30). The results showed that serum IL-2 and IL-10 levels were significantly different among schizophrenia patients. The observations indicate a significant decrease (P < 0.05) in schizophrenic patients serum levels of IL-2 compared with healthy control. Whereas detection of IL-10 in the schizophrenic patients serum showed significantly increase level (P < 0.05) compared with healthy control. The results supported that immune disturbance is related to the schizophrenia patients and might play an important role in the pathophysiology of schizophrenia.