Miracle-dz/UniFAR-FTUs huggingface dataset:
Effects of laboratory salmon louse infection on osmoregulation, growth and survival in Atlantic salmon

Abstract Anadromous Atlantic salmon (Salmo salar) rely on long ocean migrations to build energy stores for maturation and spawning. In seawater, wild Atlantic salmon are threatened by high salmon lice (Lepeophtheirus salmonis) infestation levels resulting from intensive salmonid sea-cage aquaculture. Salmon lice infection can cause a stress response and an osmotic imbalance in the host. The lice infection intensity threshold values for these responses, however, remain to be identified in Atlantic salmon. In order to define this under laboratory conditions, individually tagged F1 wild origin Atlantic post-smolts (40 g) were infected with salmon lice copepodids or left as uninfected controls. Twenty-eight days post infection, infected post-smolts had a mean of 0.38 (range of 0.07–0.9) mobile lice g−1 fish weight. During this period, specific growth rates (SGRs) were lower in infected than control fish (0.4 vs 1.0% day−1). Higher plasma Na+, Cl− and osmolality in infected fish also indicate osmoregulatory impairment. SGR correlated negatively with plasma Na+, Cl−, osmolality and cortisol in the infected, but not in the control group. Infection intensity (lice g−1 fish) correlated positively with mortality rate and plasma Na+, Cl−, osmolality and cortisol and correlated negatively with SGR and condition factor. Calculated lice intensity threshold values for changes in plasma ions were 0.18 lice g−1 for plasma Cl−, and 0.22 lice g−1 for plasma Na+. Moribund infected fish occurred at infection intensities above 0.2 lice g−1, and these fish had extreme plasma Cl−, Na+, osmolality and cortisol levels. There was a positive correlation between plasma cortisol and plasma Na+, Cl− and osmolality in infected fish. This study provides vital information that can be used to define thresholds in the monitoring and conservation of wild Atlantic salmon populations affected by aquaculture-driven salmon lice infestations.
Mental health of children and adolescents in foster care residential institutions in Northern Taiwan

Objectives: Studies reposted that children and adolescents entering foster care systems are at risk of mental health conditions. In this study, we intended to describe the prevalence of mental illnesses as well as the characteristics of emotional and behavioral problems of children and adolescents in foster care residential institutions in Northern Taiwan. Methods: From July 2011 to January 2014, we recruited 97 children and adolescents from four foster care residential institutions due to child maltreatment or loss of dependency. They were assigned through the social welfare bureau (three group homes, n = 76) or the judiciary department due to delinquent or conduct behaviors (one youth home, n = 21). Psychiatric illnesses were diagnosed through semi-structured interviews using the Kiddie Schedule for Affective Disorder and Schizophrenia, Epidemiological Version. Emotional and behavioral problems were assessed by main caregivers in foster care residential institutions and the youths themselves. Results: We found higher rates of lifetime (54.6% in total, 44.7% in group home, and 90.5% in youth home) and current (28.9% in total, 31.6% in group home, and 19.0% in youth home) for any psychiatric disorders among the children and adolescents in the foster care residential institutions compared to those in the general population in Taiwan (31.6% in lifetime and 25% current). The rates of lifetime psychiatric diagnoses in total entire cohort, group home, and youth home were as follows: attention deficit/hyperactivity disorder (15.5%, 15.8%, and 14.3%), oppositional defiant disorder (13.4%, 2.6%, and 52.4%), conduct disorder (22.7%, 6.6%, and 81.0%), posttraumatic stress disorder (4.1%, 5.3%, and 0%), adjustment disorder (11.3%, 9.2%, and 19.0%), and nicotine use disorder (12.4%, 2.6%, and 47.6%), respectively. Self-reported depression rates were 9.0% among youths aged between 8 and 16 years, and 17.2% among those aged between 8 and 12 years. Conclusion: The results underscore the importance of receiving a comprehensive mental health assessment in the beginning and periodically for those children and adolescents in foster care residential institutions for them to receive appropriate mental health care.
Antarctic petrels ‘on the ice rocks’: wintering strategy of an Antarctic seabird

There is a paucity of information on the foraging ecology, especially individual use of sea-ice features and icebergs, over the non-breeding season in many seabird species. Using geolocators and stable isotopes, we defined the movements, distribution and diet of adult Antarctic petrels Thalassoica antarctica from the largest known breeding colony, the inland Svarthamaren, Antarctica. More specifically, we examined how sea-ice concentration and free-drifting icebergs affect the distribution of Antarctic petrels. After breeding, birds moved north to the marginal ice zone (MIZ) in the Weddell sector of the Southern Ocean, following its northward extension during freeze-up in April, and they wintered there in April–August. There, the birds stayed predominantly out of the water (60–80% of the time) suggesting they use icebergs as platforms to stand on and/or to rest. Feather δ15N values encompassed one full trophic level, indicating that birds fed on various proportions of crustaceans and fish/squid, most likely Antarctic krill Euphausia superba and the myctophid fish Electrona antarctica and/or the squid Psychroteuthis glacialis. Birds showed strong affinity for the open waters of the northern boundary of the MIZ, an important iceberg transit area, which offers roosting opportunities and rich prey fields. The strong association of Antarctic petrels with sea-ice cycle and icebergs suggests the species can serve, year-round, as a sentinel of environmental changes for this remote region.
Caveolin as a Novel Potential Therapeutic Target in Cardiac and Vascular Diseases: A Mini Review

Caveolin, a structural protein of caveolae, play roles in the regulation of endothelial function, cellular lipid homeostasis, and cardiac function by affecting the activity and biogenesis of nitric oxide, and by modulating signal transduction pathways that mediate inflammatory responses and oxidative stress. In this review, we present the role of caveolin in cardiac and vascular diseases and the relevant signaling pathways involved. Furthermore, we discuss a novel therapeutic perspective comprising crosstalk between caveolin and autophagy.
A case report about anatomy applications for a physical therapy hybrid online curriculum

Background Three-dimensional digital anatomy applications can provide a powerful supplement to more traditional learning modalities. The challenge for medical libraries and educators is to select an app that best supports anatomical learning objectives and then effectively integrate it into health sciences curricula. App selection is particularly important when traditional learning modalities, such as cadaver dissection, are not feasible. Selection was a challenge at the authors’ university, as the doctor of physical therapy (DPT) program expanded into a hybrid online environment. Case Presentation Reported here are our: (1) analysis and identification of an anatomy app to supplement cadaver lab instruction for DPT students who were enrolled in a hybrid program, where the majority of instruction took place online; (2) description of the implementation process; and (3) discussion of student feedback and the library’s perspective. Features and shortcomings of two anatomy apps, Complete Anatomy (CA) 2019 by 3D4 Medical and Human Anatomy Atlas (HAA) 2019 by Visible Body, were reviewed. CA was selected based on smoother navigation, visually appealing graphics, and user customization tools. The library purchased 1,000 CA redemption codes as a pilot program. Video recordings and live demonstrations of the app were used for instruction. Student feedback indicated extensive use. Based on success of the pilot, the library will purchase additional licenses. Conclusions Medical libraries can use our experience as an example to help select anatomy resources that would be useful when considering the conversion of health sciences programs into online environments and further guide app integration to supplement other anatomical models.
Aboriginal prisoners with cognitive impairment: Is this the highest risk group?

Early estimates point to higher rates of cognitive impairment among Indigenous Australians in custody compared to non-Indigenous Australians. This study sought to examine the prevalence of cognitive impairment in a representative sample of Indigenous offenders from Victorian prisons. Differences in mental illness prevalence, offending history and post-release recidivism were explored by presence of cognitive impairment. Results revealed an over-representation of cognitively impaired prisoners in the sample and a large minority with concomitant mental illness or disability. Cognitively impaired prisoners were more likely to re-offend, were younger at first offence, and had greater numbers of prior offences. Findings signal the need for culturally themed disability assistance and diversionary options at all levels of the criminal justice system.
Why do bugs perish? Range size and local vulnerability traits as surrogates of Odonata extinction risk

Despite claims of an insect decline worldwide, our understanding of extinction risk in insects is incomplete. Using bionomic data of all odonate (603 dragonflies and damselflies) North American species, we assessed (i) regional extinction risk and whether this is related to local extirpation; (ii) whether these two patterns are similar altitudinally and latitudinally; and (iii) the areas of conservation concern. We used geographic range size as a predictor of regional extinction risk and body size, thermal limits and habitat association as predictors of local extirpation. We found that (i) greater regional extinction risk is related to narrow thermal limits, lotic habitat use and large body size (this in damselflies but not dragonflies); (ii) southern species are more climate tolerant but with more limited geographic range size than northern species; and (iii) two priority areas for odonate conservation are the cold temperate to sub-boreal northeastern USA and the transversal neo-volcanic system. Our approach can be used to estimate insect extinction risk as it compensates for the lack of abundance data.
Study of pepsin level in saliva as a noninvasive marker for diagnosis of gastroesophageal reflux disease

Objective This study aimed to evaluate the role of salivary pepsin level as a noninvasive marker for diagnosis of gastroesophageal reflux disease (GERD) and its endoscopic severity. Background GERD is one of the most commonly encountered gastrointestinal diseases. Confirmation of the diagnosis mostly entails the use of invasive procedures. Salivary pepsin level has been discussed previously in studies of extraesophageal symptoms of GERD. Patients and methods This study was conducted on 50 patients with clinical and endoscopic evidences of erosive reflux disease (GERD group) versus 25 patients with upper gastrointestinal symptoms not consistent with GERD and in whom endoscopic findings proved absence of GERD (non-GERD group). In addition, 20 healthy participants were selected as a control group. Patients and control were subjected to GERD Q questionnaire, upper gastrointestinal endoscopy, and quantitative measurement of salivary pepsin using ELISA kits. Results There was a highly significant increase in the mean value of salivary pepsin in GERD group (88.64 ± 46.37 ng/ml) when compared with non-GERD (38.08 ± 35.57) and control group (18.65 ± 14.71) (P = 0.0008 and 0.001, respectively), whereas there was no significant difference (P = 0.226) between non-GERD and control group. There was a highly significant increase (P = 0.0008) in mean value of salivary pepsin in patients with GERD complicated with Barrett's esophagus (152.50 ± 27.12) when compared with patients with GERD without this complication (76.48 ± 38.70). Conclusion Salivary pepsin is a simple noninvasive marker for diagnosis of GERD and its severity.
An exploratory study of cannabis use pattern and treatment seeking in patients attending an addiction treatment facility

Background and Aims: Although cannabis is the most common illicit substance of use in India, it is often not the presenting complaint of patients with substance use disorders. The present study aimed to understand the profile of cannabis use disorders among patients at a substance abuse treatment facility in an Indian tertiary care center. Materials and Methods: This was a cross-sectional interview-based study which assessed adult patients with substance use disorders who had a history of cannabis use in the recent past. Participants were evaluated for cannabis use disorder as per the Diagnostic and Statistical Manual of Mental Disorders-5 (DSM-5) and cannabis dependence as per the International Classification of Diseases, 10th revision (ICD-10). They were assessed for cannabis withdrawal, and treatment-seeking behavior about cannabis use was explored. Results: Among the 100 male participants in the study, the use of smoked form (charas, ganja, sulfa) was more common than oral form (bhang). Fifty-eight patients fulfilled the ICD-10 criteria of dependence, whereas 74 patients fulfilled the DSM-5 criteria of cannabis use disorder. Tolerance, craving, and withdrawal were the most common clinical features. Only 7 patients ever sought help for quitting cannabis, whereas 28 patients thought that generally treatment is required for quitting cannabis. Conclusion: More cannabis users seem to fulfill a diagnosis of cannabis use disorder as per DSM5 than cannabis dependence as per ICD-10. Treatment seeking for cannabis use disorders seems to be low among the substance using patients. Clinicians need to focus on cannabis use as well when they treat patients with substance use disorders.
Systematic Suicide Screening in a General Hospital Setting: Process and Initial Results

Background: Suicide is one of the leading causes of death across all age groups globally and poses a significant public health burden. In response to the United States Joint Commission National Patient Safety Goals, a tertiary hospital in the Northeast U.S. developed a suicide risk assessment and response protocol, consisting of systematic screening of patients for suicidal ideation/behavior with a screening version of the Columbia Suicide Severity Rating Scale (C-SSRS) and a response algorithm based on risk levels derived from the screen. Methods: A total of 837 nurses were trained and 24,168 patients ages 12 and above were screened with the C-SSRS Screener. Results: Posttraining interrater reliability on the C-SSRS Screener definitions of ideation and behavior was high and independent of level of education or mental health experience. Of the patients screened, only 144 patients (0.93%) were in the highest risk category, and they were assigned patient safety monitors until a follow-up consultation. The highest risk levels from the C-SSRS Screener reasonably identified subsequent attempts at self-injurious behavior during hospitalization. Screening resulted in lower burden due to reduction in the rate of psychiatric consultations and one-to-one observation shifts. Conclusions: These findings suggest that a systematic screening and clinical response protocol using the C-SSRS Screener can potentially enhance the ability to identify suicide risk in the general hospital population and focus services on patients with the most need.
Enhancing Resilience and Mental Health of Children and Adolescents by integrated School- and Family-based Approaches, with a Special Focus on Developing Countries: A Narrative Review and Call for Action

Global mental health (GMH) is important for sustainable futures, but neglected, especially in low- and middle-income countries (LMICs). Child and adolescent mental heath (CAMH) is one of the essential components of GMH. CAMH is influenced by several factors and at several levels, of which resilience to adversity or stress is an integral component. In this narrative review, we first explore the concept of individual and family resilience (FR) and then review various resilience promoting interventions at school and family/community settings across the world but with a special focus on published research arising from LMICs. Resilience has been traditionally conceptualized at the individual level, but FR is also very important, especially in LMICs where there are severe resource constraints. Resilience, contrary to what was thought initially, is not an inherent, innate, unmodifiable personality “trait” but rather a dynamic multilevel systemic “process” that is changeable over time and in turn changes the outcomes related to mental health, adjustment, and thriving in the face of adversity and stress. An important corollary of this reframed conceptualization of resilience is that resilience – both at the individual and family level – is changeable and hence lends itself to interventions. These interventions can be school based (e.g., by imparting life skills education [LSE] in schools) and/or family/community based. Published studies in the area of CAMH, resilience, LSE, and related areas are heavily biased toward high-income countries, with a wide gap in published research from LMICs. However, the limited available literature suggests that such interventions are at least partially effective, and potentially feasible in LMICs, despite challenges. The available evidence also demonstrates the need for (a) using a multicomponent intervention; (b) involving families and focusing on family functioning as well; (c) using trained lay counsellors and peers rather than depending solely on teachers and health practitioners; and (d) working within a context of the culturally and locally sensitive needs, with a longitudinal perspective. Based on this review, we sound a call for action by proposing to develop, through research, models for promoting resilience at both individual and family levels, by working with children and adolescents and their families in school and family settings in an integrated manner in India and Kenya.
Expanding the mutualistic niche: parallel symbiont turnover along climatic gradients

Keystone mutualisms, such as corals, lichens or mycorrhizae, sustain fundamental ecosystem functions. Range dynamics of these symbioses are, however, inherently difficult to predict because host species may switch between different symbiont partners in different environments, thereby altering the range of the mutualism as a functional unit. Biogeographic models of mutualisms thus have to consider both the ecological amplitudes of various symbiont partners and the abiotic conditions that trigger symbiont replacement. To address this challenge, we here investigate ‘symbiont turnover zones'––defined as demarcated regions where symbiont replacement is most likely to occur, as indicated by overlapping abundances of symbiont ecotypes. Mapping the distribution of algal symbionts from two species of lichen-forming fungi along four independent altitudinal gradients, we detected an abrupt and consistent β-diversity turnover suggesting parallel niche partitioning. Modelling contrasting environmental response functions obtained from latitudinal distributions of algal ecotypes consistently predicted a confined altitudinal turnover zone. In all gradients this symbiont turnover zone is characterized by approximately 12°C average annual temperature and approximately 5°C mean temperature of the coldest quarter, marking the transition from Mediterranean to cool temperate bioregions. Integrating the conditions of symbiont turnover into biogeographic models of mutualisms is an important step towards a comprehensive understanding of biodiversity dynamics under ongoing environmental change.
Cutaneous manifestation of β-thalassemic patients

Objective The aim was to study the prevalence of common dermatological problems in patients with β-thalassemia major to help rapid treatment and prevent complications. Background β-Thalassemia major affects multiple organs and is associated with considerable morbidity and mortality. In β-thalassemia, a wide spectrum of skin diseases was identified, which were caused by both the hemoglobin disorder and the complications of treatment. Patients and methods This cross-sectional study included 105 Egyptian patients (50 female individuals and 55 male individuals) with transfusion-dependent β-thalassemia major in the period spanning from June 2017 to February 2018. The study was performed on child and adult patients of β-thalassemia who presented to the hematology clinic, Menoufia University hospital. Skin examination of each patient was carried out, and any skin disease present was recorded. Results The main skin disorders that were noticed in decreasing order of frequency were pruritus (34.4%), xerosis (24.8%), urticaria (21.1%), freckles (17.1%), tinea infections (11.6%), pitriasis alba reported in 10.5%, scars (10.5%), hypersensitivity to deferoxamine pump (9.5%), herpes simplex (9.5%), acne vulgaris (8.6%), miliaria (6.7%), contact dermatitis (4.8%). Conclusion Skin diseases were frequent among patients with β-thalassemia major. The most common skin lesions in our patients were pruritus, xerosis, and hyperpigmentation. Careful skin examination of thalassemia patients is required to provide early diagnosis of dermatological diseases and a better quality of life.
Neurocognitive and clinical correlates of insight in schizophrenia

Background: Schizophrenia is a heterogeneous disorder characterized by various symptom dimensions and neurocognitive deficits. Impairment of insight is a core clinical symptom of the disorder. There has been an increasing focus on neurocognition and insight in schizophrenia; although, many studies fail to control for premorbid cognitive status. Materials and Methods: Schizophrenia patients (n = 60) selected for adequate background education were recruited from outpatient services of a tertiary care hospital and community care homes in Southern India. These patients were comprehensively assessed using a neurocognitive battery. Clinical assessments were done using the Positive and Negative Syndrome Scale (PANSS) and Schedule for the Assessment of Insight-expanded version (SAI-E). Partial correlation was performed to examine the relationship of insight with clinical and neurocognitive measures. Statistical significance was set at P = 0.004 (Bonferroni correction for 12 tests of association). Linear regression analysis was performed to examine the predictors of insight. Results: The mean PANSS positive, negative, general psychopathology, and total scores were 14.2 ± 4.9, 17.4 ± 5.0, 34.3 ± 6.8, and 65.8 ± 13.9, respectively. Mean insight score (SAI-E) was 8.5 ± 2.9. In partial correlation done after controlling for IQ, significant negative correlations were observed between insight score and the Wisconsin Card Sorting Test (WCST) total errors (P = 0.001), WCST perseverative errors (P < 0.001). Insight scores had negative correlations with PANSS negative (P < 0.002) and total scores (P < 0.002). WCST perseverative errors were the primary predictor of insight in the regression analysis. Conclusion: Insight has a strong relationship with executive functioning in schizophrenia. This could indicate shared neurobiological substrates for insight and executive functioning.