Miracle-dz/UniFAR-FTUs huggingface dataset:
Impact of food restriction on the medio‐basal hypothalamus of intact ewes as revealed by a large‐scale transcriptomics study

In mammals, the medio‐basal hypothalamus (MBH) integrates photoperiodic and food‐related cues to ensure timely phasing of physiological functions, including seasonal reproduction. The current human epidemics of obesity and associated reproductive disorders exemplifies the tight link between metabolism and reproduction. Yet, how food‐related cues impact breeding at the level of the MBH remains unclear. In this respect, the sheep, which is a large diurnal mammal with a marked dual photoperiodic/metabolic control of seasonal breeding, is a relevant model. Here, we present a large‐scale study in ewes (n = 120), which investigated the impact of food restriction (FRes) on the MBH transcriptome using unbiased RNAseq, followed by RT‐qPCR. Few genes (~100) were impacted by FRes and the transcriptional impact was very modest (<2‐fold increase or < 50% decrease for most genes). As anticipated, FRes increased expression of Npy/AgRP/LepR and decreased expression of Pomc/Cartpt, while Kiss1 expression was not impacted. Of particular interest, Eya3, Nmu and Dio2, genes involved in photoperiodic decoding within the MBH, were also affected by FRes. Finally, we also identified a handful of genes not known to be regulated by food‐related cues (e.g., RNase6, HspA6, Arrdc2). In conclusion, our transcriptomics study provides insights into the impact of metabolism on the MBH in sheep, which may be relevant to human, and identifies possible molecular links between metabolism and (seasonal) reproduction.
Investigating Degree of Inequality in Public University Administration: The Case of Ambrose Alli University and University of Benin, Edo State, Nigeria

Previous studies on gender equality in public universities were limited because they focused on the gender composition of the teaching and non-teaching staff. This study seeks to bridge this gap by examining gender equality/inequality status of the university management staff. The focus was on Ambrose Alli University (AAU), Ekpoma and University of Benin (Uniben), Benin City, both in Edo State. The study relied on secondary data on staffing from both institutionswhile primary data were collected using question guide administered on key informants among the management cadre of the universities. Data were analysed using percentage, means, Chi-square test of proportion and content analysis characteristic of qualitative interviews. The findings revealed gender inequality in staffing among the management staff cadre between the two institutions (AAU: male = 88.13%, female = 11.87%; Uniben: male = 75.1%, female = 24.1%). The gender differences was significant in favour of male (χ2: AAU = 414.47; Uniben = 422.69). Similar trend in distribution was observed among principal officers of AAU with men constituting a total average of 83.33% and women 16.67%. Major factors identified by the key informants for the gender inequality included cultural/institutional and political factors, lack of basic educational qualifications, domestic duties and lack of mentorship. The study recommends among others, the need for women in management positions to mentor younger women while women in tertiary institutions should be encouraged to improve on the educational qualifications.
Dielectric and Piezoelectric Properties of (1-x)(0.36BiScO3-0.64 PbTiO3)-xBiYbO3 Ceramics

(1-x)(0.36BiScO3–0.64PbTiO3)-xBiYbO3 (BSYPTx) piezoelectric ceramics were synthesized by the conventional mixed oxide ceramic processing. The Curie temperature of samples was found in the range from 435°C to 454°C due to the addition of 0.02 ∼ 0.14 mol% BiYbO3. The piezoelectric coefficient d 33 of BSYPTx ceramics decreased with increasing Yb content, exhibiting good piezoelectric properties (d 33 = 443 pC/N and k p = 0.54) at x = 0.02. The coercive field (E c) for BSYPTx ceramics at x = 0.02 was 2.86 kV/mm, increasing to 3.19 kV/cm with the addition of Yb content to x = 0.14.
Parental Alienating Behaviours Experienced by Alienated Grandparents

This study explored parental alienating behaviours experienced by grandparents with limited or no contact with their grandchildren. Twelve alienated grandparents participated in semi-structured interviews investigating their experience of alienation. The data were analysed using an inductive thematic analysis approach. Alienated grandparents reported being exposed to 13 parental alienating behaviours used by the alienating parent. These behaviours are consistent with those reported by targeted parents and adult alienated children in other studies. This study showed that parental alienating behaviours also affects grandparent-child relationships. Further research is needed to better understand the impact of parental alienation on grandparents and the wider family system.
Sample Size Calculations for Clustered and Longitudinal Outcomes in Clinical Research

Sample Size Determination for Independent Outcomes Introduction Precision Analysis Power Analysis Sample Size Determination for Clustered Outcomes Introduction One-Sample Clustered Continuous Outcomes One-Sample Clustered Binary Outcomes Two-Sample Clustered Continuous Outcomes Two-Sample Clustered Binary Outcomes Stratified Cluster Randomization for Binary Outcomes Nonparametric Approach for One-Sample Clustered Binary Outcomes Sample Size Determination for Repeated Measurement Outcomes Using Summary Statistics Introduction Information Needed for Sample Size Estimation Summary Statistics Sample Size Determination for Correlated Outcome Measurements Using GEE Motivation Review of GEE Compare the Slope for a Continuous Outcome Test the TAD for a Continuous Outcome Compare the Slope for a Binary Outcome Test the TAD for a Binary Outcome Compare the Slope for a Count Outcome Test the TAD for a Count Outcome Sample Size Determination for Correlated Outcomes from Two-Level Randomized Clinical Trials Introduction Statistical Models for Continuous Outcomes Testing Main Effects Two Level Longitudinal Designs: Testing Slope Differences Cross-Sectional Factorial Designs: Interactions between Treatments Longitudinal Factorial Designs: Treatment Effects on Slopes Sample Sizes for Binary Outcomes Sample Size Determination for Correlated Outcomes from Three Level Randomized Clinical Trials Introduction Statistical Model for Continuous Outcomes Testing Main Effects Testing Slope Differences Cross-Sectional Factorial Designs: Interactions between Treatments Longitudinal Factorial Designs: Treatment Effects on Slopes Sample Sizes for Binary Outcomes Further Readings appear at the end of each chapter.
Assessing the Acceptability of Home Blood Monitoring for Patients With Cancer Who Are Receiving Systemic Anticancer Therapy From a Patient, Caregiver, and Clinician Perspective: Focus Group and Interview Study

Background Regular blood testing is an integral part of systemic anticancer therapy delivery. Blood tests are required before every administration of treatment to ensure that a patient is sufficiently well to receive it. Blood testing is burdensome for patients as they require either an extra visit within 48 hours of planned administration of treatment or a significantly long visit if performed on the day of treatment. The additional time for appointments can have a significant impact on the quality of life of someone who is living with cancer. In the United Kingdom, the COVID-19 pandemic created unprecedented disruption to the delivery of cancer care. Face-to-face hospital visits were reduced, resulting in the need to develop more innovative ways of working to minimize treatment interruptions. This led to significant uptake of digital technologies, with new models of care rapidly deployed across the UK health service to meet these challenges. Objective This study aimed to explore the acceptability of a point-of-care home blood monitoring device for people with cancer who are receiving systemic anticancer therapy, which is being developed in response to the increased need for remote care for patients with cancer. Methods Qualitative focus groups and semistructured interviews were conducted with patients (23/47, 49%), caregivers (6/47, 13%), and health care professionals (18/47, 38%) over a 19-month time frame from May 2019 to December 2020. Data were analyzed using framework analysis guided by the Unified Theory of Acceptance and Use of Technology model. Results Analysis identified 4 overarching themes: performance expectancy, effort expectancy, social influence, and facilitating conditions. Conclusions This study found that patients with cancer, their caregivers, and health care professionals had positive perceptions about home blood monitoring. Although they are often considered synonymously, self-testing and self-management are not mutually exclusive, and this study illustrated some disparity in opinions regarding patient self-management. Home blood monitoring has the potential to provide patients with cancer with a convenient option for blood monitoring. It would minimize hospital attendances, decrease late treatment deferrals, and provide prompt recognition of cancer treatment toxicities, thus enhancing the existing nurse-led protocols and clinical pathways. Home blood monitoring would create a long-term sustainable transformation for the delivery of cancer care, using digital health to act as a facilitator to address a pertinent issue regarding improving the efficiency of hospital resources and increasing the delivery of personalized patient care. Further studies are needed to determine how and where home blood monitoring would fit within clinical pathways, in a way that is robust and equitable.
Auxiliaries and Supervisors at War: The Spillover Effect of Supervisor-Subordinate Aggression on University Staff Productivity

Using Kampala International University (KIU) as a study sample, the study inquired into the effect of the continued use of aggression on employee productivity. Utilizing a cross-sectional survey design, data were collected sequentially using a mixed method sequential approach from a statistically representative sample of 108 senior academics for numerical data and 10 key informants for qualitative interviews. Findings revealed that when all the four parameters of X were taken together, explained only 22.1% variation in Y (adjusted r2 = 0.221). Again, any unit increase in any of the predictors was accompanied by an inverse reaction in the predicted variable, and for this reason, the multiple linear regression model was insignificant (F. =55.361, p. = 0.088 > 0.05). However, unlike the quantitative data, interview responses indicated that whereas retaliation is counterproductive, it has been a potential recipe for growth in some instances although at a negligible scale. Qualitative data further revealed that, the impact of aggression consistently reduces with a consistent corresponding increase in positive reinforcement such as bonuses, prompt monthly pay, and staff development schemes. Since employee satisfaction and organizational success are mutually exclusive, the study recommends a balanced approach that aligns organizational interests with employee needs and aspirations for a productive working environment.
Do the Co-Morbid Conditions are Risk Factors for COVID-19 Patients? A View in a Tertiary Care Center

Aims: This study aimed to characterize the COVID-19 patient’s demographic details, Symptoms, and to identify whether co-morbid conditions aggravated the COVID-19 symptoms and their vitality in the COVID-19 patients. The other aims were to identify HINI, whether, age, lab-investigations, and CT grading have changed between only COVID-19 patients and COVID-19 patients with Co-morbid conditions. Methods: In an isolation ward of the tertiary care unit, 509, COVID-19 patients were admitted. The patient’s throat swab was collected and performed Real-Time- Polymerase Chain Reaction (RTPCR), and recorded the confirmed cases for further investigations, diagnosis, and treatment. Patient’s demographic details, Co-morbid
The effect of team formation on match running performance in UEFA Champions League matches: implications for position-specific conditioning

ABSTRACT This study aimed to determine the effect of team formation on position-specific match running performance (MRP) at highest-level football. Players’ MRP (n = 226) was observed in four team formations: 3-5-2 (n = 24), 4-4-2 (n = 44), 4-2-3-1 (n = 77) and 4-3-3 (n = 81). Central defenders in the 3-5-2 formation achieved a greater amount of high-intensity running distance than in the 4-3-3 formation (mean difference (MD) [95% confidence interval] = 144 m [12, 267], medium ES). Fullbacks in the 4-4-2 formation covered less total distance than in 3-5-2 (MD = −762 m [−1431, −94], large ES) and 4-2-3-1 (MD = −662 m [−1055, −269], medium ES). Central midfielders’ total distance in the 4-4-2 formation was lower than that in the 3-5-2 (MD = −645 m [−79, −1211], medium ES) and 4-3-3 (MD = −656 m [−1181, −132], medium ES) formations. Wide midfielders’ walking distance in the 4-4-2 formation was lower than that in the 4-3-3 (MD = −484 m [-742, -226], very large ES) and 4-2-3-1 (MD = −535 m [−789, −282], very large ES) formations. Forwards’ high-intensity running in the 4-2-3-1 formation was lower than that in the 4-3-3 (MD = −363 m [−613, −112], large ES) and 4-4-2 (MD = −396 m, [−688, −103], large ES) formations. These findings show that conditioning programs for players on all playing positions should be tailored according to the formations of their teams.
Relationship between fetal middle cerebral artery pulsatility index and cerebroplacental ratio with adverse neonatal outcomes in low-risk pregnancy candidates for elective cesarean section: A cross-sectional study

Abstract Background The cerebroplacental ratio (CPR) is an important factor for predicting adverse neonatal outcomes in appropriate-for-gestational-age fetuses. Objective To evaluate whether there is an association between the CPR level and adverse neonatal outcomes in appropriate-for-gestational-age fetuses. Materials and Methods This cross-sectional study included 150 low-risk pregnant women candidates for elective cesarean sections at the gestational age of 39 wk. CPR and middle cerebral artery pulsatility index (MCA PI) were calculated in participants just before cesarian section. Postnatal complications were defined as an adverse neonatal outcome such as an Apgar score of the neonate ≤ 7 at 5 min, neonatal intensive care unit (NICU) admission, cord arterial pH ≤ 7/14, and meconium stained liquor. Results The mean age of participants was 31.53 ± 4.91 yr old. The mean CPR was reported as 1.83 ± 0.64. The Chi-square test analysis revealed that a low MCA PI and a low CPR were significantly associated with decreased cord arterial pH, decreased Apgar score at 5 min, and NICU admission (p < 0.001). There was no significant association between umbilical artery PI with arterial cord pH, Apgar score at 5 min, NICU admission, or meconium stained liquor. The Mann-Whitney test showed that a lower fetal weight appropriate for the women's gestational age was significantly associated with a decreased CPR and MCA PI (p < 0.005). There was no significant association between amniotic fluid index and CPR, umbilical artery PI, or MCA PI. Conclusion The CPR is a significant factor in predicting adverse neonatal outcomes and ultimately neonatal mortality and morbidity of low risk, appropriate-for-gestational-age fetuses.
Angular and range interferometry to refine weather radar resolution

A weather radar's resolution volume is generally determined by beam and pulse widths. Recently, a single‐antenna interferometric technique was developed to measure cross‐beam and radial wind using angular and range interferometry. Here it is shown that the interferometry technique can refine radar resolution. The technique for resolution refinement is based on the fact that the cross‐correlation function of signals from two resolution volumes is contributed only by scatterers in the shared volume. Therefore all the radar measureables derived from cross‐correlation estimates have a resolution of the shared volume size rather than a radar resolution volume size. The performance of the technique depends on the shape of beam/range‐weighting functions and relative sample error. A sharp change at the edges of the weighting function and low sidelobes are important for resolution refinement using weather radar interferometry.
C/EBPβ Promotes LPS-Induced IL-1β Transcription and Secretion in Alveolar Macrophages via NOD2 Signaling

Objective C/EBPβ, a crucial transcription factor, regulates innate immunity and inflammatory responses. However, the role played by C/EBPβ in alveolar macrophage (AM) inflammatory responses remains unknown. This study aimed to investigate the role and mechanism of C/EBPβ in alveolar macrophages (AMs) from the transcriptional level and to search for natural compounds targeting C/EBPβ. Methods Rat AMs were infected with Lv-sh-C/EBPβ and treated with LPS, and the expression levels of iNOS, TNF-α, IL-6, and IL-1β were measured by RT-qPCR, Western blotting, and ELISA. Mechanistically, transcriptome sequencing (RNA-seq) revealed changes in gene expression patterns in AMs after LPS stimulation and C/EBPβ knockdown. Functional enrichment analyses and rescue experiments identified and validated inflammation-associated cell signaling pathways regulated by C/EBPβ. Furthermore, virtual screening was used to search for natural compounds that inhibit C/EBPβ with the structure of helenalin as a reference. Results Following stimulation with LPS, AMs exhibited an increased expression of C/EBPβ. C/EBPβ knockdown significantly decreased the expression levels of inflammatory mediators. A total of 374 differentially expressed genes (DEGs) were identified between LPS-stimulated C/EBPβ knockdown and negative control cells. The NOD-like receptor signaling may be a key target for C/EBPβ, according to functional enrichment analyses of the DEGs. Further experiments showed that the muramyl dipeptide (MDP, NOD2 agonist) reversed the downregulation of inflammatory mediators and the NF-κB pathway caused by the C/EBPβ knockdown. The virtual screening revealed that N-caffeoyltryptophan, orilotimod, and petasiphenone have comparable pharmacological properties to helenalin (a known C/EBPβ inhibitor) and demonstrate a great binding capacity to C/EBPβ. Conclusion Ablation of C/EBPβ may attenuate LPS-induced inflammatory damage in AMs by inhibiting the NOD2 receptor signaling pathway. Three natural compounds, N-caffeoyltryptophan, orilotimod, and petasiphenone, may be potential C/EBPβ inhibitors.
Vertical and oblique ionospheric soundings over a very long multihop HF radio link from polar to midlatitudes: Results and relationships

A vertical incidence sounder (VIS) was installed at the Spanish Antarctic Base (62.7°S, 299.6°E) during the Antarctic summer survey 2004–2005. In addition, an oblique sounding (OS) system for HF communications between Antarctica and Spain (12,700 km) has been operated during the Antarctic summers since December 2003. OS results are compared to Rec533 model and to VIS data obtained from stations located along the radio path, including VIS stations at the emitter and receiver sites. The results presented in this paper show the potential of this infrastructure for ionospheric monitoring and research purposes at and from polar regions. The results also show that relevant information (e.g., maximum received frequency) of very long range radio links can be obtained from appropriate VIS stations along the path.
Average HbA1c in Diabetic Patients in Southern KPK-Pakistan

Abstract Diabetes mellitus is a complex metabolic syndrome characterized by either insulinopenia or insulin resistance. This study is focused on the ever-growing prevalence of diabetes mellitus and its poor glycemic control in southern KPK This descriptive cross-sectional study was conducted at the outdoor unit, Department of medicine DHQ hospital Bannu, over six months, extending from 30th December 2021 to 30th June 2022. The sample size was 91 and was calculated using the standard WHO formula. The confidence interval used was 95%, with a 5% margin of error. P value <0.05 was taken as statistically significant. Consecutive non-probability sampling technique was applied. Diabetic patients under treatment below 70 years were included in the study. HbA1c was used as an assessment tool for glycemic control and divided into three categories: good glycemic control with HbA1c<7%, poor glycemic control with HbA1c>9%, and very poor glycemic control with HbA1c>10%. Data was entered and analyzed using SPSS version 19.0. About 18.6% diabetic patients had HbA1c>6%, 25.6% patients had HbA1c between6-8%, 26.7 % patients had HbA1c between 8-10% and 29.6 % had HbA1c>10%. This study revealed that the majority (55%) of diabetic patients belonging to southern KPK had poor glycemic control, as revealed by HbA1c, more than 8%.
Solar X-ray Jets Observed with the X-ray Telescope aboard Hinode

The X-Ray Telescope (XRT) aboard Hinode has revealed the fine structure of solar X-ray jets. One of the fine structures observed by XRT is an expanding loop. The loop appeared near the footpoint of the jet when footpoint brightening was observed. Additionally, we have found that the X-ray jets began just after the expanding loop “breaks”. Other fine structures discovered by XRT are thread-like features along the axis of the jets. XRT has shown that these thread structures compose the cross-section of jets. The fine structures and their motions strongly support an X-ray jet model based on magnetic reconnection, and also suggest that we must consider the three-dimensional configuration of the magnetic field to understand the jet phenomenon. We also investigated the reverse jet associated with the X-ray jet in the quiet Sun, and propose that the reverse jet is produced by heat conduction, or a MHD wave subsequent to the main jet.
Response of a baryon-charged medium to energetic partons

We explore the response to energetic partons of a baryon-charged medium produced in low energy heavy-ion collisions in which the partonic energy loss rate is expected to depend on both temperature and baryon chemical potential. The energy and momentum deposited by the partons are described by dynamical sources added to hydrodynamic equations of motion. We study the distortions of various hydrodynamic quantities, especially the energy and baryon densities, induced by energetic partons plowing through the medium. By studying the contribution from this medium response to the emission spectra of several identiﬁed hadron species we identify qualitative diﬀerences between the jet-induced modiﬁcations for mesons and net protons.
Hubble Space Telescope V-Band Imaging of the Bipolar Proto-Planetary Nebula IRAS 17150–3224

We report Hubble Space Telescope Wide Field Planetary Camera 2 imaging of the bipolar proto-planetary nebula IRAS 17150-3224. We find a series of concentric arcs superposed on the two reflection nebular lobes, similar to those observed in AFGL 2688. This suggests that periodic mass-loss enhancement is a common phenomenon in the asymptotic giant branch (AGB) phase. The near circular shape of the arcs suggests that mass loss is spherically symmetric during the AGB phase and that the bipolar morphology develops only after the end of the AGB phase. The possible evolution in morphology from proto-planetary nebulae to planetary nebulae is discussed.