Miracle-dz/UniFAR-FTUs huggingface dataset:
Association between WeChat Use and Memory Performance among Older Adults in China: The Mediating Role of Depression

Changes to memory performance in the course of aging may be influenced by behavioral factors. The use of social media among elderly people is increasing, but studying its effect on cognitive functions such as memory remains at an early stage of development. Meanwhile, the linking mechanisms underlying the association between social media use and memory performance, if any exist, have not been revealed. This study attempted to examine the association between the use of WeChat, the most popular social media platform in China, and memory performance among older people, and to test the possible mediating role of depression underlying this association. Data were drawn from the five-wave survey of the China Family Panel Study (CFPS), and 4929 respondents aged 60 or older (mean age = 68.19, SD = 5.84, 48.2% females) were included. Based on the descriptive statistics, the chi-squared test, Student’s t-test, correlation analysis, and mediation analysis were conducted. The results indicated that the usage rate of WeChat among the sample was 20.1%. After controlling for demographic variables, the use of WeChat was related to higher levels of memory performance and lower levels of depression. Moreover, depression partially mediated the relationship between WeChat use and memory performance. To maintain memory performance and promote cognitive health in the course of aging, using social media and alleviating depression merit special attention.
A Branched and Double Alpha-Gal-Bearing Synthetic Neoglycoprotein as a Biomarker for Chagas Disease

Chagas disease (CD) is caused by the parasite Trypanosoma cruzi and affects 6–7 million people worldwide. The diagnosis is still challenging, due to extensive parasite diversity encompassing seven genotypes (TcI-VI and Tcbat) with diverse ecoepidemiological, biological, and pathological traits. Chemotherapeutic intervention is usually effective but associated with severe adverse events. The development of safer, more effective therapies is hampered by the lack of biomarker(s) (BMKs) for the early assessment of therapeutic outcomes. The mammal-dwelling trypomastigote parasite stage expresses glycosylphosphatidylinositol-anchored mucins (tGPI-MUC), whose O-glycans are mostly branched with terminal, nonreducing α-galactopyranosyl (α-Gal) glycotopes. These are absent in humans, and thus highly immunogenic and inducers of specific CD anti-α-Gal antibodies. In search for α-Gal-based BMKs, here we describe the synthesis of neoglycoprotein NGP11b, comprised of a carrier protein decorated with the branched trisaccharide Galα(1,2)[Galα(1,6)]Galβ. By chemiluminescent immunoassay using sera/plasma from chronic CD (CCD) patients from Venezuela and Mexico and healthy controls, NGP11b exhibited sensitivity and specificity similar to that of tGPI-MUC from genotype TcI, predominant in those countries. Preliminary evaluation of CCD patients subjected to chemotherapy showed a significant reduction in anti-α-Gal antibody reactivity to NGP11b. Our data indicated that NGP11b is a potential BMK for diagnosis and treatment assessment in CCD patients.
The Inflammasome Activity of NLRP3 Is Independent of NEK7 in HEK293 Cells Co-Expressing ASC

The cytosolic immune receptor NLRP3 (nucleotide-binding domain, leucine-rich repeat (LRR), and pyrin domain (PYD)-containing protein 3) oligomerizes into the core of a supramolecular complex termed inflammasome in response to microbes and danger signals. It is thought that NLRP3 has to bind NEK7 (NIMA (never in mitosis gene a)-related kinase 7) to form a functional inflammasome core that induces the polymerization of the adaptor protein ASC (Apoptosis-associated speck-like protein containing a CARD (caspase recruitment domain)), which is a hallmark for NLRP3 activity. We reconstituted the NLRP3 inflammasome activity in modified HEK293 (human embryonic kidney 293) cells and showed that the ASC speck polymerization is independent of NEK7 in the context of this cell system. Probing the interfaces observed in the different, existing structural models of NLRP3 oligomers, we present evidence that the NEK7-independent, constitutively active NLRP3 inflammasome core in HEK293 cells may resemble a stacked-torus-like hexamer seen for NLRP3 lacking its PYD (pyrin domain).
Precover completing domains and approximations

Abstract In this paper, we introduce an -precover completing domain , with being a class of modules and not necessarily a single module, and then investigate when every module in has an -preenvelope. Epic and monic -preenvelopes are also investigated. This study plays a key role in setting a general framework for several classical results. Then, for a class of finitely generated modules , we introduce the notion of -R-Mittag-Leffler modules as a natural extension of R-Mittag-Leffler modules. This enabled us to find easier proofs of some known results and also establish new ones.
Characterization of motion power loss of off‐road wheeled robot in a slippery terrain

For the first time in realm of power study of off‐road wheeled robots, this study deals with motion power loss due to slippage of robot wheels traversed on slippery terrain. For this purpose, effects of slippery terrain type (solid balls with diameter of 0.0127, 0.0254, and 0.0508 m), tire air pressure (20.68, 34.47, and 55.16 kPa), and robot forward speed (0.17, 0.33, and 0.5 m/s) on the power loss were characterized. Derived results proved that the increasing effect of slippery terrain type on the power loss was dominant (1.08 and 3.21 times) than that of robot forward speed and tire air pressure, respectively. Meanwhile, the increasing effect of robot forward speed on the power loss was prevailed (2.98 times) than that of tire air pressure. Hence, to minimize the power loss of the robot traversed on each type of slippery terrain, adjustment of robot forward speed should be considered as first priority. A comparison between motion power loss (43.60–249.40 W) and provided motion power for the robot (136–436.37 W) implies that 12.93–75.44% of provided motion power was wasted by slippage of the robot wheels on slippery terrains. Overall, the analytical results obtained in this study lead to open a new prospection for comprehending of the power loss trends of off‐road wheeled robots traversed on slippery terrains. As slippery terrain composed of solid balls, the results can be especially utilized for final phase of unloading robotic operations of catalyst handling procedure in process towers and reactors of oil, gas, petrochemical, and chemical industries.
Intensity of Depression Symptoms Is Negatively Associated with Catalase Activity in Master Athletes

Background: This study examined associations between scores of depression (DEPs), thiobarbituric acid-reactive substances (TBARS), superoxide dismutase (SOD), and catalase activity (CAT) in master athletes and untrained controls. Methods: Participants were master sprinters (MS, n = 24; 50.31 ± 6.34 year), endurance runners (ER, n = 11; 51.35 ± 9.12 year), untrained middle-aged (CO, n = 13; 47.21 ± 8.61 year), and young untrained (YU, n = 15; 23.70 ± 4.02 year). CAT, SOD, and TBARS were measured in plasma using commercial kits. DEPs were measured by the Beck Depression Inventory-II. An ANOVA, Kruskal-Wallis, Pearson’s, and Spearman’s correlations were applied, with a significance level of p ≤ 0.05. Results: The CATs of MS and YU [760.4 U·μL 1 ± 170.1 U·μL 1 and 729.9 U·μL 1 ± 186.9 U·μL 1] were higher than CO and ER. The SOD levels in the YU and ER [84.20 U·mL−1 ± 8.52 U·mL−1 and 78.24 U·mL−1 ± 6.59 U·mL−1 (p < 0.0001)] were higher than CO and MS. The TBARS in CO [11.97 nmol·L−1 ± 2.35 nmol·L−1 (p < 0.0001)] was higher than in YU, MS and ER. MS had lower DEPs compared to the YU [3.60 ± 3.66 vs. 12.27 ± 9.27 (p = 0.0002)]. A negative correlation was found between CAT and DEPs for master athletes [r = −0.3921 (p = 0.0240)] and a weak correlation [r = −0.3694 (p = 0.0344)] was found between DEPs and the CAT/TBARS ratio. Conclusions: In conclusion, the training model of master sprinters may be an effective strategy for increasing CAT and reducing DEPs.
Headmaster Perception of The Implementation of The Curriculum Principle Content (Catch-Up Plan) of Sri Aman Area, Sarawak

In era of the COVID-19 pandemic, had a profound impact on the whole country especially our country's education sector. Most of the education institutions had to be closed under the Movement Control Order. As a result, the Ministry of Education is learning new norms such as teaching and learning at home. Various programmes were introduced such as empowering curriculum Implementation (KPM Perkasaku) which is the Basic Content Curriculum (Catch-up Plan) programme conducted at the school level. The implementation of the Basic Curriculum Content in schools is one of initiatives of the Ministry of Education Malaysia. The school needs to conduct various interventions and coordination to preserve the implementation of the Basic Curriculum Content in schools. This study is a survey study that requires researchers to collect data using a quantitative approach where researchers need to review the headteacher's perception of the implementation of Basic Curriculum Content. As a result, 32 headmasters responded to the implementation of the Basic Curriculum Content involving 32 primary schools in Sri Aman district. The implementation this program as one of the ways for teachers to help pupils who have not yet mastered 3M skills can follow the teaching and facilitation without dropping out.
Accurate characterization and understanding of interface trap density trends between atomic layer deposited dielectrics and AlGaN/GaN with bonding constraint theory

Many dielectrics have been proposed for the gate stack or passivation of AlGaN/GaN based metal oxide semiconductor heterojunction field effect transistors, to reduce gate leakage and current collapse, both for power and RF applications. Atomic Layer Deposition (ALD) is preferred for dielectric deposition as it provides uniform, conformal, and high quality films with precise monolayer control of film thickness. Identification of the optimum ALD dielectric for the gate stack or passivation requires a critical investigation of traps created at the dielectric/AlGaN interface. In this work, a pulsed-IV traps characterization method has been used for accurate characterization of interface traps with a variety of ALD dielectrics. High-k dielectrics (HfO2, HfAlO, and Al2O3) are found to host a high density of interface traps with AlGaN. In contrast, ALD SiO2 shows the lowest interface trap density (<2 × 1012 cm−2) after annealing above 600 °C in N2 for 60 s. The trend in observed trap densities is subsequently ex.
Mediterranean Diet and White Matter Hyperintensity Change over Time in Cognitively Intact Adults

Current evidence on the impact of Mediterranean diet (MeDi) on white matter hyperintensity (WMH) trajectory is scarce. This study aims to examine whether greater adherence to MeDi is associated with less accumulation of WMH. This population-based longitudinal study included 183 cognitively intact adults aged 20–80 years. The MeDi score was obtained from a self-reported food frequency questionnaire; WMH was assessed by 3T MRI. Multivariable linear regression was used to estimate the effect of MeDi on WMH change. Covariates included socio-demographic factors and brain markers. Moderation effects by age, gender, and race/ethnicity were examined, followed by stratification analyses. Among all participants, WMH increased from baseline to follow-up (mean difference [follow-up-baseline] [standard deviation] = 0.31 [0.48], p < 0.001). MeDi adherence was negatively associated with the increase in WMH (β = −0.014, 95% CI = −0.026–−0.001, p = 0.034), adjusting for all covariates. The association between MeDi and WMH change was moderated by age (young group = reference, p-interaction[middle-aged × MeDi] = 0.075, p-interaction[older × MeDi] = 0.037). The association between MeDi and WMH change was observed among the young group (β = −0.035, 95% CI = −0.058–−0.013, p = 0.003), but not among other age groups. Moderation effects by gender and race/ethnicity did not reach significance. Greater adherence to MeDi was associated with a lesser increase in WMH over time. Following a healthy diet, especially at younger age, may help to maintain a healthy brain.
Post-ERCP pancreatitis occurs more frequently in self-expandable metallic stents than multiple plastic stents on benign biliary strictures: a meta-analysis

Abstract Background The occurrence of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP) after using covered self-expandable metallic stents (CSEMS) and multiple plastic stents (MPS) in the therapy of benign biliary strictures (BBS) remains ambiguous, this analysis aimed to evaluate the outcomes. Methods A systematic search of electronic databases (PubMed, Web of Science and Cochrane Library) was conducted for randomised controlled trials (RCTs), and the included studies were published between 2008 and 2021. The primary outcome was PEP, while the secondary outcomes were stricture resolution, recurrence, overall adverse events, costs, and ERCP sessions. Pooled effect sizes were calculated with the random-effects model or fixed-effects model depending on the heterogeneity. Results Six RCTs contained 444 patients (221 with CSEMS, 223 with MPS) finally included in the meta-analysis. The present analysis shows that compared to MPS, PEP is more likely to occur in CSEMS (OR [odds ratio] = 3.34, 95% confidence intervals [CI]:1.44–7.77, p = .005). CSEMS needs fewer ERCP sessions (Mean Deviation [MD]: −1.56; 95%CI:−2.66, −0.46], p = .006). The difference in stricture resolution and recurrence was not significant between the two stent types (OR = 0.87, 95%CI: 0.49–1.56, p = .64; and OR = 2.3, 95%CI: 0.68–7.76, p = .18). The incidence of overall adverse events was comparable between CSEMS and the MPS group (OR = 1.49, 95% CI: 0.97–2.29, p = .07). Conclusions Compared with MPS, CSEMS caused a significantly higher incidence of PEP but fewer ERCP procedures, while the rate of stricture resolution, recurrence, and overall adverse events were comparable. Prevention methods of PEP should be further evaluated in BBS when undergoing CSEMS placement. Systematic Review Registration PROSPERO CRD42022314864. Key messages CSEMS and MPS placement remain a mainstay for patients with BBS, and severe complications after stent placement have not been compared. The incidence of PEP was higher after deployment of CSEMS compared to MPS. Prevention methods of PEP should be evaluated in BBS when undergoing CSEMS placement.
The energy production rate density of cosmic rays in the local universe is $\sim10^{44-45}\rm erg~Mpc^{-3}~yr^{-1}$ at all particle energies

The energy output (per logarithmic interval of particle energies) of Cosmic Rays (CRs) with energies $10{\rm GeV}\lesssim\varepsilon_p\lesssim100{\rm GeV}$ is $\sim 10^{47}\rm erg$ per solar mass of star$-$formation, based on the CR production rate in the Milky Way and in starburst galaxies, implying a generation rate of $\varepsilon_p^2Q\sim 10^{45}\rm erg~Mpc^{-3}~yr^{-1}$ in the local universe. It is only $\sim 10$ times larger than the output, $\varepsilon_p^2 Q=0.5\pm0.2\times 10^{44}\rm erg~Mpc^{-3}~yr^{-1}$, of Ultra High Energy CRs (UHECRs) at energies $10^{10.5}{\rm GeV}<\varepsilon_p<10^{12}\rm GeV$ (obtained assuming they are mostly protons), which in turn is comparable to the lower limit of $\varepsilon_p^2 Q\ge 0.5\times 10^{44}\rm erg~Mpc^{-3}~yr^{-1}$ of high energy CRs with $10^6{\rm GeV}\lesssim\varepsilon_p\lesssim 10^{8}\rm GeV$ implied by the saturation of the Waxman-Bahcall bound by the neutrino excess recently discovered by IceCube. These similarities are consistent with a flat production spectrum, $\varepsilon_p^2 Q\sim \text{const}$ for CRs at all observed energies. If a flat production spectrum is generated by our galaxy, the observed CR flux in the range $10^{6.5}-10^{9.5}\rm GeV$, above the "knee", is suppressed compared to lower energies due to propagation effects rather than acceleration upper limits. As suggested by Parizot and Aublin, the most exciting possibility is that cosmic rays at all energies are emitted from a single type of (unknown) sources, which can not be supernova remnants.
Potential Health-Promoting Effects of Two Candidate Probiotics Isolated from Infant Feces Using an Immune-Based Screening Strategy

Commensal microorganisms in the human gut are a good source of candidate probiotics, particularly those with immunomodulatory effects that may improve health outcomes by regulating interactions between the gut microbiome and distal organs. Previously, we used an immune-based screening strategy to select two potential probiotic strains from infant feces in China, Bifidobacterium breve 207-1 (207-1) and Lacticaseibacillus paracasei 207-27 (207-27). In this study, the in vitro immunological effects and potential in vivo general health benefits of these two strains were evaluated using Lacticaseibacillus rhamnosus GG (LGG) as the control. The results showed that 207-1 and 207-27 significantly and differentially modulated the cytokine profiles of primary splenic cells, while did not induce abnormal systemic immune responses in healthy mice. They also modulated the gut microbiota composition in a strain-dependent manner, thus decreasing Gram-negative bacteria and increasing health-promoting taxa and short-chain fatty acid levels, particularly butyric acid. Conclusively, 207-1 and 207-27 shaped a robust gut environment in healthy mice in a strain-specific manner. Their potential immunomodulatory effects and other elite properties will be further explored using animal models of disease and subsequent clinical trials. This immune-based screening strategy is promising in efficiently and economically identifying elite candidate probiotics.
Evidence of Intersubband Linewidth Narrowing Using Growth Interruption Technique

We report on the systematic study of two main scattering mechanisms on intersubband transitions, namely ionized impurity scattering and interface roughness scattering. The former mechanism has been investigated as a function of the dopants position within a multiple GaAs/AlGaAs quantum well structure and compared to the transition of an undoped sample. The study on the latter scattering mechanism has been conducted using the growth interruption technique. We report an improvement of the intersubband (ISB) transition linewidth up to 11% by interrupting growth at GaAs-on-AlGaAs interfaces. As a result, the lifetime of intersubband polaritons could be improved up to 9%. This leads to a reduction of 17% of the theoretical threshold intensity for polaritonic coherent emission. This work brings a useful contribution towards the realization of polariton-based devices.
The Peak Brightness and Spatial Distribution of Asymptotic Giant Branch Stars Near the Nucleus of M32

The bright stellar content near the center of the Local Group elliptical galaxy M32 is investigated with 0. ″12 FWHM H and K images obtained with the Gemini Mauna Kea telescope. Stars with K = 15.5, which are likely evolving near the tip of the asymptotic giant branch (AGB), are resolved to within 2'' of the nucleus, and it is concluded that the peak stellar brightness near the center of M32 is similar to that in the outer regions of the galaxy. Moreover, the projected density of bright AGB stars follows the visible light profile to within 2'' of the nucleus, indicating that the brightest stars are well mixed throughout the galaxy. Thus, there is no evidence for an age gradient, and the radial variations in spectroscopic indices and ultraviolet colors that have been detected previously must be due to metallicity and/or some other parameter. We suggest that either the bright AGB stars formed as part of a highly uniform and coherent galaxy-wide episode of star formation or they originated in a separate system that merged with M32.
Multiphase Converter Voltage Optimization With Minimum Effort Principle

Multiphase converters are systems with multiple degrees of freedom (DOF) and provide space for control optimization. Widely spread space vector pulsewidth modulation methods offer competitive results. However, they are rather complicated due to high number of switching states and are designed for a specific <inline-formula><tex-math notation="LaTeX">$n$</tex-math></inline-formula>-phase system or operation mode. For special cases, e.g., when total harmonic distortion should be reduced or fault-tolerant mode is required, they lead to complicated and specialized solutions. In this article, a minimum effort principle for leg-voltage optimization is proposed. This efficient approach is based on the minimum infinity norm solution and it effectively exploits the DOF. It is shown that the approach is universal and applicable to <inline-formula><tex-math notation="LaTeX">$n$</tex-math></inline-formula>-phase systems and to both standard and fault-tolerant modes. Moreover, it enables to implement constraints on DOF and adjust trade-off between maximum output voltage and THD. To meet the requirements of real-time applications, an effective algorithm of low processing power is proposed.
A precise determination of the psibar-psi anomalous dimension in conformal gauge theories

A strategy for computing the psibar-psi anomalous dimension at the fixed point in infrared-conformal gauge theories from lattice simulations is discussed. The method is based on the scaling of the spectral density of the Dirac operator or rather its integral, the mode number. It is relatively cheap, mainly for two reasons: (a) the mode number can be determined with quite high accuracy, (b) the psibar-psi anomalous dimension is extracted from a fit of several observables on the same set of configurations (no scaling in the Lagrangian parameters is needed). As an example the psibar-psi anomalous dimension has been computed in the SU(2) theory with 2 Dirac fermions in the adjoint representation of the gauge group, and has been found to be 0.371(20). In this particular case, the proposed strategy has proved to be very robust and effective.
Microbial Tryptophan Metabolism Tunes Host Immunity, Metabolism, and Extraintestinal Disorders

The trillions of commensal microorganisms comprising the gut microbiota have received growing attention owing to their impact on host physiology. Recent advances in our understandings of the host–microbiota crosstalk support a pivotal role of microbiota-derived metabolites in various physiological processes, as they serve as messengers in the complex dialogue between commensals and host immune and endocrine cells. In this review, we highlight the importance of tryptophan-derived metabolites in host physiology, and summarize the recent findings on the role of tryptophan catabolites in preserving intestinal homeostasis and fine-tuning immune and metabolic responses. Furthermore, we discuss the latest evidence on the effects of microbial tryptophan catabolites, describe their mechanisms of action, and discuss how perturbations of microbial tryptophan metabolism may affect the course of intestinal and extraintestinal disorders, including inflammatory bowel diseases, metabolic disorders, chronic kidney diseases, and cardiovascular diseases.