Miracle-dz/UniFAR-FTUs huggingface dataset:
Influence of Topiramate and Valproate Acid on Insulin and Leptin Levels in Epileptic Patients

Aim:To investigate whether changes of insulin and leptin levels play a role in the weight loss associated with topiramate and the weight gain associated with valproate acid in epileptic patients. Methods:142 epileptic patients were chosen ,55 cases of them received topiramate monotherapy and 35 cases did not,24 cases received valproate acid monotherapy and 28 cases as their control group.The fasting serum insulin and leptin levels were measured by radioimmunoassay(RIA). Results:①Topiramate and control group:The mean fasting serum insulin level of topiramate group was less than control group(P=0.025),especially to female patients (P=0.040); There was no statistical difference between the mean fasting serum leptin level of the two groups(P=0.42),but the mean fasting serum leptin level of male patients was less than that of female patients in the two groups (control group:P=0.001,topiramate group:P=0.022). ② Valproate acid and control group:There was no statistical difference between the mean fasting serum insulin level of the two groups(P=0.368),but in VPA group,the mean fasting serum insulin level of obese patients was higher than nonobese patients(P=0.032);The mean fasting serum leptin level of valproate acid group was higher than control group,especially to obese patients(P=0.011). The mean fasting serum leptin level of obese patients was higher than nonobese in valproate acid group(P=0.037). Conclusion:Topiramate reduced fasting serum insulin level of nonobese epileptic patients significantly,especially to female patients; Valproate acid had no influence on fasting serum insulin level of epileptic patients,but can increase their fasting serum leptin level,especially to obese epileptic patients.
Lie Algebras of Finite and Affine Type

1. Basic concepts 2. Representations of soluble and nilpotent Lie algebras 3. Cartan subalgebras 4. The Cartan decomposition 5. The root systems and the Weyl group 6. The Cartan matrix and the Dynkin diagram 7. The existence and uniqueness theorems 8. The simple Lie algebras 9. Some universal constructions 10. Irreducible modules for semisimple Lie algebras 11. Further properties of the universal enveloping algebra 12. Character and dimension formulae 13. Fundamental modules for simple Lie algebras 14. Generalized Cartan matrices and Kac-Moody algebras 15. The classification of generalised Cartan matrices 16 The invariant form, root system and Weyl group 17. Kac-Moody algebras of affine type 18. Realisations of affine Kac-Moody algebras 19. Some representations of symmetrisable Kac-Moody algebras 20. Representations of affine Kac-Moody algebras 21. Borcherds Lie algebras Appendix.
Clinical Treatment of the Benign Prostatic Hyperplasia with Tonglong Qibi Decoction

Objective:To observe the clinical effect and safety of tonglong qibi decoction on benign prostatic hyperplasia(BPH). Method:To divide randomly 82 BPH cases into the treatment group(n=41) treated with Tonglong Qibi Decoction orally and the control group(n=41) treated with Qianlieshule Granules(QLSLG). The changes of the traditional Chinese medicine symptoms score(TCMSS),the International Prostate Symptoms Score(IPSS),quality of life(QOL) score and maximum urine rate of flow(Qmax),postvoiding residual volume(PRV),prostate volume(PV),prostate specific antigen(PSA),were observed before and after the treatment,and recorded the adverse events.Result:The total effective rate was 90.2% in the treatment group,and 70.7% in the control group,the difference being significant between the two groups(P0.05). The TCMSS,IPSS,QOL,and PRV were reduced Significantly,Qmax were improved significantly,in the treatment group compared to those of the control group(all P0.05). PV and PSA decreased more in the treatment group than in the control group,but without statistical significance(P 0.05). Conclusion:Tonglong qibi decoction could effectively decrease the objective parameters and subjective symptoms.It is safe in the treatment of BPH.
Clinical profile of refractive errors in children in a tertiary care hospital of Northern India

Background: Refractive errors constitute a major portion of children with visual impairment. Aim of this study was to study the pattern of refractive errors and its association with selected variables (age, sex, educational status, socioeconomic status, amblyopia and strabismus). Methods: This was hospital based observation descriptive study. The study was conducted on 781 eyes of 396 children, 5-15 years of age attending the ophthalmology OPD of a tertiary care teaching hospital of North India. Interpretation and analysis of obtained results was carried out using SPSS version 22 and non-parametric tests like Pearson Chi-square test was used. Results: Mean age of presentation was 10.90±3.16 years with male: female ratio of 1.8:1. 57.07% mothers and 70.20% fathers were intermediate and above. Number of children from lower middle socioeconomic status (40.90%) and with a positive family history of refractive errors (59.59%) was higher. 7.07% children had amblyopia and 6.06% children had strabismus. Most of the children with refractive errors were having mild (≤1.5D) refractive error (61.20%) and not using spectacles previously (78.30%). Astigmatism was found in 46.99% followed by myopia (41.23%) and hypermetropia (11.78%). The UCVA was >6/12 in 48.27% eyes. Conclusions: This study reinforces the previously reported pattern of refractive errors and its association with others variables except that a large number of children were found to have refractive errors but not using spectacles in this area. Risk of refractive error in children was associated with higher level of education of mother which has not been reported earlier.
Investigation on incidence of geriatric depression in a rural community of Anhui province

Objective To understand the incidence of geriatric depression and explore the risk factors of geriatric depressions in rural community of Anhui countries.Methods 1236 non-depressed elderly of the study on rhe prevalence of depression among the elderly was followed up with one-year interval by using the Geriatric Mental State Schedule(GMS-AGECAT) and Minimum Data Set(MDS). The data were analysis and by SPSS.Results The incidence of depression among the elderly was7.2%. χ~2 analysis and Multinomial Logistic Regression analysis showed that there was significantly difference between the male and female(P0.05),but the incidence of geriatric depression between different age,marital status,job and education degrees didn't have significant difference.Gender was risk factor of geriatric depression in the rural community(P0.05,(RR:1.68,95%CI1.07～2.64). Conclusion The incidence of geriatric depression is higher than what is expected.Female elderly is the high-risk population of geratric epression in the rural community and when interventions are maken,they should be focusd on.
Applied analysis of the Navier-Stokes equations: Index

The Navier–Stokes equations are a set of nonlinear partial differential equations comprising the fundamental dynamical description of fluid motion. They are applied routinely to problems in engineering, geophysics, astrophysics, and atmospheric science. This book is an introductory physical and mathematical presentation of the Navier–Stokes equations, focusing on unresolved questions of the regularity of solutions in three spatial dimensions, and the relation of these issues to the physical phenomenon of turbulent fluid motion. Intended for graduate students and researchers in applied mathematics and theoretical physics, results and techniques from nonlinear functional analysis are introduced as needed with an eye toward communicating the essential ideas behind the rigorous analyses.
Sleeping Disorders and the Influencing Factors Among Children Aged 2-6 in Shenyang City

Objective To study the prevalence and its influencing factors to sleeping disorders among children aged 2-6 in Shenyang, and to provide evidence for children’s sleeping disorders. Methods Questionnaire survey was conducted among parents of children (aged 2-6) in five kindergartens. ResultsThe average sleeping time was 9.7±1.1 hours for the children. The total prevalence rate of sleeping disorders was 27.40%,and the disorders were difficulty falling asleep(7.86%),easy wake or early wake(4.39%),being addicted to sleep(2.16%),night talking(3.01%),sleep bruxism(6.09%),nightmare(0.39%),snoring(5.94%),wake in night(1.08%),shaking head(0.08%),sleeping-convulsion(0.08%) and narcoleptic syndrome(0.08%),and there was no difference between genders.The sleep disorders could be affected by environment of family and social,as well as eating and drinking before sleep. ConclusionHigh prevalence of sleep disorders is found among the children aged 2-6 in Shenyang.The environment of family and society show a cetain influence on sleep disorders.It is necessary to take corresponding measure to decrease and prevent the incidence of children's sleep disorders.
Fertility preservation in female cancer patients:a single center experience

Advances in cancer treatment allow women to be cured and live longer. However, the necessary chemotherapy and radiotherapy regimens have a negative impact on future fertility. Oncofertility has emerged as a new interdisciplinary field to address the issue of gonadotoxicity associated with cancer treatment and to facilitate fertility preservation, including oocyte and ovarian tissue cryopreservation. These fertility issues are often inadequately addressed, and referral rates to oncofertility centers are low. The aim of this study was to report the 3-year experience of the San Raffaele Oncofertility Unit. A total of 96 patients were referred to the Oncofertility Unit for evaluation after the diagnosis of cancer and before gonadotoxic treatment between April 2011 and June 2014. Of the 96 patients, 30(31.2%) were affected by breast cancers, 20(20.8%) by sarcomas, 28(29.2%) by hematologic malignancies, 13(13.5%) by central nervous system cancers, 3(3.1%) by bowel tumors, 1(1.0%) by Wilms' tumor, and 1(1.0%) by a thyroid tumor; 47(49.0%) were referred for oocyte cryopreservation before starting chemotherapy, 20(20.8%) were referred for ovarian tissue cryopreservation, and 29(30.2%) were not recruited. The mean time between the patients' counseling and oocyte retrieval was 15 days(range, 2–37 days). The mean time between the laparoscopic surgery and the beginning of treatment was 4 days(range, 2–10 days). The number of patients who were referred increased over time, whereas the rate of patients who were not recruited decreased, showing an improvement in referrals to the Oncofertility Unit and in the patients' counseling and understanding. Our results indicate that an effective multidisciplinary oncofertility team is necessary for prompt referrals and treatment.
GLOBAL EXISTENCE AND GENERAL DECAY ESTIMATES OF SOLUTIONS FOR DEGENERATE OR NONDEGENERATE KIRCHHOFF EQUATION WITH GENERAL DISSIPATION

In this paper, first we prove the existence of global solution in Sobolev spaces for the initial boundary value problem of the (degenerate or nondegenerate) Kirchhoff equation with a general dissipation of the form u′′ − φ (∫ Ω |∇u| dx ) ∆u+ σ(t)g(u′) = 0 in Ω× IR+. The estimation of the energy decay of the modified second energy plays an important role in the proof. Then we prove general stability estimates using multiplier method and general weighted integral inequalities proved by the second author in [15]. Without imposing any growth condition at the origin on g and φ, we show that the energy of the system is bounded above by a quantity, depending on σ and g, which tends to zero (as time goes to infinity). In the degenerate case, our stability estimate depends also on φ. These estimates allows us to consider large class of functions g and φ with general growth at the origin. We give many significant examples to illustrate how to derive from our general estimates the polynomial, exponential or logarithmic decay. The results of this paper improve and generalize many existing results in the literature, and generate some interesting open problems.
Prognosis effect of early enteral nutrition support in patients with severe burn

Objective To study the effect of early enteral nutrition support on rehabilitation of patients with severe burn.Methods 80 patients with large area burn were randomly divided into observation group and control group.The early enteral nutrition support was given in observation group.The intestines nutrition support was given in control group.Patients' wound recovery and nutritional status were compared between the two groups.Results Positive nitrogen balance recovery time and wound healing time of observation group were more significantly shortened than those of control group.There was statistically significant difference between groups (P0.05). The serum endotoxin in observation group was reduced significantly.The incidence of sepsis and nutritional status were superior to those of control group.There was statistically significant difference between groups (P0.05). Conclusion Early enteral nutrition support in burn treatment can effectively reduce the high metabolic reactions,serum endotoxin and infectious complications of patients,and improve the nutritional status to facilitate the patients' recovery.
Clinico-pathological changes associated with diaphragmatic hernia and foreign body syndrome in buffaloes

Clinico-pathological studies were undertaken on 16 cases of diaphragmatic hernia (DH) and 7 cases of foreign body syndrome (FRS). Haemoglobin concentration, TEc and pCv values were considerably less in 5 cases of DH and 4 cases of FBS. Anaemia in DH was macrocytic and normochromic. In FBS it was macrocytic and normochromic. Leucocytosis with reversal of neutrophil and lymphocyte ratio could be seen. Biochemical values revealed increase of SGOT, AIP and GGT in majority of cases under study. Protein level significantly decreased in almost all cases
Costs of Emergency Department Visits and Hospitalizations for Pulmonary Arterial Hypertension

Copyright: © 2016 Stein PD, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. *Corresponding author: Paul D Stein, Michigan State University, College of Osteopathic Medicine, Detroit Medical Center, USA, Tel: 248701 7210; Fax: 313 578 9601; Email: steinp@msu.edu
Effect of Tongxinluo Capsule on Inflammatory Reaction and Vascular Endothelial Function of Acute Myocardial Infarction Patients After Percutaneous Coronary Intervention

Objective:To observe the effect of Tongxinluo Capsule (TC) on inflammatory reaction and vascular endothelial function of acute myocardial infarction (AMI) patients after percutaneous coronary intervention (PCI) . Methods:One hundred and twenty AMI patients received coronary arteriography and PCI. After operation, the patients were randomized into 2 groups:58 in the control group were given routine western medicine, and 62 in the treatment group were given routine western medicine and TC. The treatment in the two groups lasted 6 months. During the treatment, the incidence of cardiovascular events, blood lipid levels, inflammatory biological markers and vascular endothelial function were recorded in all of the patients. Results:In the treatment group, serum levels of interleukin 6 (IL 6) and hypersensitive C reactive protein (hs CRP) were decreased after treatment ( P 0. 05 or P 0. 01 compared with those before treatment and with those in the control group after treatment). Blood lipid levels and serum levels of endothelin 1 (ET 1 ) and oxidized low density lipoprotein (ox LDL) were decreased, and serum nitric oxide was increased after treatment ( P 0. 05 compared with those before treatment and with those in the control group after treatment) . Conclusion:Treatment with TC on the basis of routine western medicine is effective on decreasing inflammatory reaction and improving vascular endothelial function in AMI patients after PCI, the adverse reaction being less.
Patients’ Perception of Service Quality of Health Care Services in India

Service quality is considered as a key component for employer brand that is determined through customers’ satisfaction. In this context, the primary goal of the health care industry is to provide the best possible service to their patients in order to sustain in the market. An assessment will give an opportunity to find out the loopholes in the services for future rectifications and to reach the desired goal. This study is, therefore, an attempt to measure the perception of patients regarding quality of health care services in India along with a comparative study on urban and rural hospitals. Here, current status of health care service quality and preferred service dimensions of urban and rural patients in India was investigated through literature review and questionnaire survey. Data were collected from 368 patients, who were then hospitalized or already discharged. The Service Quality Measurement scale (SERVQUAL) was applied to verify the hypotheses. The findings reveal that the health care service quality was unsatisfactory and patients’ preferences of dimensions were distinct in urban and rural areas. These gaps exist due to lack of knowledge, costly modern medical substances and treatments and so on. The study has implication in maintaining standard of health care service quality, making policies and serving research purposes.
Treatment Plans and Interventions for Insomnia: A Case

Of all the conundrums mental health professionals face, our attitude toward sleep difficulties must be one of the strangest. We all know that sleep is paramount: we spend a third of our lives asleep or trying to get to sleep and billions of dollars a year on everything from Ambien and white noise machines to “sleep consultants. ” What’s more, as scientists and mental health professionals we know that few condition are more universally associated with psychiatric dysfunction than sleep disturbance. And yet, despite the enormous importance of sleep and staggering lengths we all go to get more of it, as clinicians we can be surprisingly dismissive of sleep difficulties.
On a Standard Temperature for Clinical Enzymology

The need for a standard temperature for clinical enzyme assays is discussed. The inadequacy of temperature correction factors is demonstrated and from this it is inferred that reaction and standard temperature must be the same. The advantages and disadvantages of various temperatures are examined and it is concluded that 37°C is the most practical of the alternatives.
Central Simple Algebras and Galois Cohomology

1. Quaternion algebras 2. Central simple algebras and Galois descent 3. Techniques from group cohomology 4. The cohomological Brauer group 5. Severi-Brauer varieties 6. Residue maps 7. Milnor K-theory 8. The Merkurjev-Suslin theorem 9. Symbols in positive characteristic Appendix: A breviary of algebraic geometry References Index.
RESPONS DOKTER DAN KESIAPAN PEMANGKU KEPENTINGAN DALAM IMPLEMENTASI UNDANG UNDANG PRAKTIK KEDOKTERAN DI KOTA MEDAN

The implementation of Law No. 29/2004 on Medical Practice (LMP) that involves many stakeholders need to be assessed in order to improve the policy and health system. This study aims to assess the implementation of LMP in Medan in 2007 â�� 2012, through doctors response on the Law and throught stakeholder preparedness to implement the law. This study employs a mixed method. Results: 10 years after the launch of LMP, doctors have shown good faith to accept and implement. Good faith is based on the majority of that 60% (6 of 10 Variable Response) has responded to â�¥ in both categories by a doctor, except on legal sanctions and the role played by law enforcement and NGOs as environmental factors. Ministry of Health, as part of its function, duty and jurisdiction, have succeeded in designing regulation on medical practice, through Minister of Health (MOH) Decree and the MOH Act. The Indonesian Medical Council (IMC) and the Indonesian Honorary Council for Medical Disciplinary (IHCMD) as part of its function, duty and jurisdiction internally regulated medical practice through IMC regulation and IMC act, administer doctor registration and establish educational standard for medical profession. IHCMD has enforced doctor and dentist to comply to Case Management of Doctor Dentist Disciplinary Violation. However, the level of implementation of this enforcement has not been considered proactive. MOH and IMC have not intensively employed their advisory and monitoring roles on the management of medical practice. District level health office, as part of its function, duty and jurisdiction has issued registration for medical practice, record and map medical practices in its territory. However, again, its advisory and monitoring roles have not been intensively explored. In addition, district level regulation on medical practice has still not been established. In accordance to the LMP, associations of medical profession (Indonesian Doctoral Association/Indonesian Dentists Association) in Medan provide advice, conduct monitoring and enforce medical ethics. There are still gaps in perception between medical community and law enforcer regarding enforcement process of criminal law for medical practice. Multiple regression showed that doctorâ��s response to LMP missions is associated with doctorâ��s compliance to LMP (p<0.05, adj R-square=0.5173). Doctorâ��s response to penalty has the strongest association compared to other variables (A� = 0,68). Conclusion: Doctorâ��s response to LMP missions is associated with his/her compliance to the law. Stakeholders are not well prepared to implement LMP. LMP needs to be revised in order to manage its implementation by health care system. Keywords: doctorâ��s response, stakeholderâ��s preparedness, implementation of the Law of Medical Practice
Effects of Ondansetron and Granisetron on Rocuronium-induced Neuromuscular Blockade in a Rat Phrenic Nerve-hemidiaphragm Preparation

Background: Both ondansetron and granisetron exert their antiemetic effects via a blockade of the 5-hydroxytryptamine 3 receptor (). Because the is a member of a superfamily of ligand-gated ion channels and has structural similarities to the nicotinic acetylcholine receptor (nAChR), a antagonist may also inhibit the nAChR. This study examined the effects of antagonists, ondansetron and granisetron, on rocuronium-induced neuromuscular blockade in vitro. Methods: Rat phrenic nerve-hemidiaphragm preparations were isolated and allocated randomly into seven groups (control, 1, 10, 100/ml of ondansetron, 0.1, 1, 10/ml of granisetron). Two studies were carried out using single twitch responses. In the cumulative dose-response study, rocuronium 1/ml and each doses of ondansetron or granisetron were administered simultaneously, and incremental 0.5/ml doses of rocuronium were added to obtain more than 95% neuromuscular twitch inhibition. , , , and of rocuronium in each group were calculated using a logistic model. In the partial curarization study, the twitch heights were measured after administering ondansetron or granisetron (10 minutes after administering 3/ml rocuronium) and were measured 10 minutes later. The 2 twitch heights were then compared. Results: In the cumulative dose-response study, ondansetron 100/ml and granisetron 10/ml significantly reduced the of rocuronium (P ＜ 0.05). There were no intergroup differences in the partial curarization study. Conclusions: High concentration of ondansetron and granisetron enhanced the neuromuscular blockade of rocuronium. Granisetron enhanced the neuromuscular blockade of rocuronium more potently than ondansetron.