Miracle-dz/UniFAR-FTUs huggingface dataset:
Paleogene Sedimentary Records of the Paleo‐Jinshajiang (Upper Yangtze) in the Jianchuan Basin, Yunnan, SW China

Cenozoic surface uplift of Tibetan Plateau has driven the birth and reorganization of large river systems in Asia. The development of the Yangtze River, closely linked to plateau uplift, has important implications for the regional tectonic‐geomorphology processes, but is still under debate. The key scientific question is whether the Upper Yangtze (upper Jinshajiang) once flowed southeast to the South China Sea. In this study, we carried out provenance analysis on Paleogene sedimentary rocks in the Jianchuan Basin, composed of the Baoxiangsi, Jinsichang, and Shuanghe formations. We compared them with similar deposits in other regional basins, as well as with potential sources. Heavy‐mineral and geochemical data show that sediments from the Jinsichang formation are more mature compared with those from the Shuanghe and Baoxiangsi formations. The Jinsichang formation represents the products of a large fluvial system, whereas the Baoxiangsi formation is mainly dominated by local sources. The Shuanghe formation contains material from both distant sources and locally eroded materials. Detrital zircon U‐Pb age patterns from the Jianchuan Basin are similar to those in sediments in the Gonjo, Simao, and Chuxiong basins, and show great similarity with the modern Jinshajiang River. Statistical analysis of the zircon ages suggests that the Songpan‐Ganzi terrane was the primary source for all sediments, while the Yangtze Craton and northern Qiangtang terrane constitute secondary sources. Taken together these data confirm that a paleo‐Jinshajiang flowed south toward to the South China Sea from the SE Tibetan Plateau in the late Eocene, constraining the age of formation of the First Bend.
Risk Assessment during Covid-19 and Learning from Home: Evidence from University Students in Indonesia

COVID-19 pandemic has become an international concern. Policies to prevent the spread of disease, such as learning from home, are applied to university students. The present study examines the risk assessment in relation to physical, mental, and psychosocial condition of Indonesian students toward COVID-19 and learning from home. This study involves 838 Indonesian students. A questionnaire consisting of demographic data and constructs from a comprehensive literature study regarding COVID-19 related issues and learning from home issues was developed. Most Indonesian student respondents have a good knowledge of COVID-19 and have received accurate information from the government. The anxiety level during COVID-19 is mild. In relation to physical condition, most students reported musculoskeletal symptoms in the neck, shoulder, and back areas. The respondents conduct preventive behavior against COVID-19 spread, with lack of physical exercise. In relation to mental and psychosocial condition. In relation to mental and psychosocial condition, respondents report moderate mental workload and proper social support from lecturers and friends. In conclusion, most Indonesian university students have a good knowledge and proper attitudes toward COVID-19 and learning from home, which are important in combating and passing through the pandemic.
Crustal and Upper‐Mantle Structure Below Central and Southern Mexico

The Mexican subduction zone is a complex convergent margin characterized by a slab with an unusual morphology, an abnormal location of the volcanic arc, and the existence of slow earthquakes (slow slip events and tectonic tremors). The number of seismic imaging studies of the Mexican subduction zone has increased over the past decade. These studies have revealed the seismic wave velocity structure beneath Central and Southern Mexico. However, the existing tomographic models are either confined to specific areas or have coarse resolution. As a consequence, they do not capture the lateral and finer‐scale variations in the mantle and the crust structure. Here, we fit frequency‐dependent traveltime differences between observed and synthetic seismograms in a three‐dimensional model of Central and Southern Mexico to constrain crustal and upper mantle seismic velocity structures jointly. We use ∼3,300 seismic records, filtered between 5 and 50 s, from 74 regional earthquakes. We perform point spread function tests to assess the resolution and trade‐offs between model parameters. Our tomographic model reveals several seismic wave velocity features. These features include the geometry of the Cocos slab, the partial melting zone beneath the Trans‐Mexican Volcanic Belt, and the Yucatan slab diving below Los Tuxtlas Volcanic Field that are consistent with previous studies. We also identify horizontal structures in the lower crust and the shallow upper mantle that were not previously identified. These structures include slow seismic wave velocity anomalies that may be correlated with ultraslow seismic velocity zones and high conductivity regions, where slow earthquakes have been identified.
Bridging the gap by providing access to oncology care to rural communities: A hybrid delivery model combining in-person visits with Telehealth.

Background: Americans who live in rural areas experience unique barriers to access healthcare such as limited transportation, shortages in oncology providers, limited access to advanced services which contribute to poor health outcomes. The current COVID-19 pandemic has provided a catalyst for rapid adoption of telehealth. A regional cancer center has established a novel rural health partnership program that utilizes a hybrid model of on-site visits and telehealth to increase access to advanced oncology care for patients in rural communities. Here we describe the collaboration and benefits of this model. Methods: The rural health hybrid delivery model utilizes a combination of in-person and telehealth visits to provide immediate access to the regional center's oncology care team and specialized services such as advanced surgeries, radiation, precision medicine, and clinical trials. Speed to care was built into the model as a key feature, offering initial appointments within 3 business days from the time of the referral, wherein treatment plans are developed facilitating immediate start. The model is a collaborative partnership, ensuring a coordinated care process driven by the regional oncologists working in coordination with the local provider to meet the needs of the patient. The patient is able to decrease transportation time, cost, and obtain care closer to their support system by keeping the patient in their community for basic needs. For more complex requirements, on-site visits are coordinated. This allows access to the regional center's specialty oncology care services not available locally, while keeping the patient engaged with their local provider, which increases service utilization and expands the patient base. Leveraging telehealth visits at the local hospital ensures access to adequate broadband and technology capabilities to facilitate continuity of patient care. Results: This model provides the patient with timely access to specialty cancer care in their local community. Partnerships with two rural health systems were implemented in July and November 2020. 14 patients are enrolled in the program to date with a 100% retention rate. The turnaround time from treatment plan to treatment is 6 business days. There was a total of 62 oncology telehealth appointments, reducing patient travel by 12,705 driving miles, 310 travel hours, saving $7,380 in travel costs and accommodation. Conclusions: Telehealth provides a bridge to the rural health access gap, and advances health equity by offering specialized care to patients in their local communities. Improving access to best practice treatment strategies for all cancer patients moves us closer to resolving disparities in outcomes. Applications of this hybrid model of care to other rural sites is a promising strategy to reduce rural-urban disparities in cancer care.
MENTAL TOUGHNESS AND REJECTION SENSITIVITY IN ASSOCIATION OF WORK PERFORMANCE AMONG INTENSIVE CARE AND PSYCHIATRIC UNIT STAFF NURSES

Background: Most nurses who are working with intensive care and psychiatric patients accept psychological talents and skills as mental toughness and rejection sensitivity that affect their work performance. Aim: To determine the association of mental toughness, rejection sensitivity, and work performance among staff nurses working at intensive care unit and psychiatric unit. Setting: This study was conducted at Medical Intensive Care Unit (MICU) as a group I and Inpatient's Unit of the Psychiatric as group II. Subjects: The study subjects were composed of simple random sample of nurses (n=100) who working at the two settings. Tools: Three tools were used, Tool I: Mental Toughness Questionnaire, Tool II: Rejection Sensitivity Questionnaire, and Tool III: Nursing Work Performance Observational Checklist. Results: Majority (91.5%) of group II obtained an average level of mental toughness and rejection sensitivity compared to (54.7% and 81.1%) of group I respectively. The total mean of nurses' responses about work performance all were at moderate level Mean±SD (2.699±10.930) for group I compared to group II Mean±SD (2.368±9.081). Conclusion: There were neither associations nor correlations between mental toughness, rejection sensitivity levels and work performance levels among staff nurses working at intensive care unit and psychiatric unit nursing groups. Recommendations: Conducting educational training program for nurses at two units about mental toughness and rejection sensitivity and maintaining the periodical orientation of nurses at two units about work performance dimensions.
Synergic effect of metallic fillers as heat dissipaters in the tribological performance of a nonasbestos disk brake pad

Brake friction linings are made of materials with a highly complex formulation that helps in improving the braking performance. The selection of friction materials with good physical, mechanical, and thermal properties is vital, which will decide the braking performance. Apart from giving good physio-mechanical properties, metallic fillers act as heat dissipaters. The objective of this work is to study the synergetic effect of prominent heat dissipaters, namely copper fibers, brass fibers, and zinc powders. Three simplified formulations were developed with 10, 14, and 18 wt. % of these heat dissipaters and named DB1, DB2, and DB3, respectively. It was observed that the addition of heat dissipaters increased the thermal properties. Tribological properties are tested based on SAE J661 standards. It was observed that DB2 had a consistent and higher coefficient of friction of 0.503 with a higher wear rate (7.6%) while DB3 had adequate μ and lower wear rate. The same batches of brake pads were tested in an inertia brake dynamometer following JASO C406 and a wear test was carried out. It was observed that % fade and % recovery were better for DB2 in both cycles. The wear rate in terms of thickness was lesser for DB2 followed by DB1 and DB3. The wear mechanism was analyzed using a scanning electron microscope. The preference selection index method of optimization was used to evaluate the overall performance parameters of the brake friction composites. Heat dissipaters with 14 wt. % have proved to be the better performers, followed by 10 and 18 wt. %.
Dietary Imbalance between Natural and Added Nutrient Sources Is Associated with Higher Fat Mass in Young Non-Obese Individuals

Increased energy intake from carbohydrates and sugars has been associated with overweight and obesity, risk factors for type 2 diabetes. However, such an association is higher with westernised diets with higher amounts of processed foods. Our aim was to correlate the dietary intake of sugars and lipids from naturally present and added sources with fat mass in young individuals. We performed an observational study in 80 young non-obese individuals, who completed food frequency and nutritional knowledge (NK) questionnaires, as well as an anthropometric evaluation. Foods were divided into naturally or added sources of sugars and lipids, and the intake from both sources was calculated separately. Individuals with a higher fat mass percentage had lower NK and lower consumption of lipids and sugars from naturally present sources. Moreover, consumption of lipids and sugars from naturally present sources was negatively correlated with nutritional knowledge and anthropometric markers of overweight, especially body weight and waist circumference. In non-obese young adults, lower consumption of sugars and lipids from naturally present sources instead of added ones is higher in individuals with excessive fat mass percentage and correlated with anthropometric markers of fat mass. Such dietary imbalance is associated with lower nutritional knowledge, suggesting that it could be a strategy to strengthen the prevention of obesity and associated pathologies later in life.
ENHANCEMENT OF URANIUM PHYTOACCUMULATION FROM CONTAMINATED SOILS

Chelation and complexation of uranium (U) and soil acidification were evaluated as practical ways to solubilize, detoxify, and enhance U accumulation by plants. Sunflower (Helianthus annuus) and Indian mustard (Brassica juncea) were selected as potential U accumulators for U phytoextraction in one U mine tailing soil (469 mg U kg−1) and nine acid and calcareous soils (pH 4.7 to 8.1) contaminated with different rates (100 to 600 mg U(VI)kg−1) of uranyl nitrate (UO2(NO3)2·6H2O). To enhance U phytoextraction, organic chelates were added to soils alone or as complexed-U forms of CDTA, DTPA, EDTA, and HEDTA, and citric and oxalic acids at rates of 1 to 25 mmol kg−1, to soils with 4-week old seedlings. Dry matter production, U concentration in shoots and roots, and soil pH were measured. Contaminated soils were also evaluated for U desorption and by fractionation. Uranium desorption was performed with 2 to 20 mmol kg−1 of citric acid, CDTA, DTPA, and HEDTA. Uranium fractions [(exchangeable, carbonate, manganese (Mn), iron (Fe), organic, and residual)] were determined after 4 weeks of incubation. Plant dry matter production and U accumulation varied with soil contamination rate, chelate, organic acid form and rate, and soil type. The highest U concentration was in plants growing in calcareous soils and the lowest in clayey acid soils with high Fe and Mn oxides and organic matter content. Addition of citric and oxalic acids increased U accumulation and U translocation to the shoots significantly. Addition of 20 mmol of citric acid kg−1 to loamy acid soils reduced the soil pH to below 5.0 and increased U concentration in shoots to 1400 mg U kg−1 or by 150-fold, but addition of complexed-U forms had little effect on U translocation to shoots. Citric acid was the most effective chelate in desorption and plant accumulation of U. Uranium phytoacumulation was limited to acid soils with low adsorptive potential and to alkaline soils with carbonate minerals.
The use of taxonomic relationships among species in applied ecological research: Baseline, steps forward and future challenges

Taxonomy is more than a mere exercise of nomenclature and classi ﬁ cation of biological diversity: it pro ﬁ les the identity of species by investigating their biological and ecological traits. Taxonomy is intimately related to ecology which, in turn, cannot be a mere exercise in describing ecological patterns, but instead requires deep knowledge of species ’ biological structures, roles, interactions and functions. Thus, the study of taxonomic and phylogenetic relatedness of species is of paramount importance in ecological research, enabling insights into potential evolutionary patterns and processes, allowing a more comprehensive view of biodiversity, and providing opportunities to improve the assessment and monitoring of ecological changes in time and space. The work of K. Robert ( ‘ Bob ’ ) Clarke forged new pathways in this direction, providing new ideas and statistical tools to include and exploit taxonomic relationships in applied marine ecological studies and beyond, also inspir-ing the next generation of ecologists. In this short review, we synthesise the application and development of these tools and concepts in marine biodiversity research over the last three decades and suggest future pathways in this evolving ﬁ eld.
Brain type natriuretic peptide increases L-type Ca2+ current in atrial myocytes by activating natriuretic peptide receptor A

xi List of Abbreviations Used . xii Acknowledgement . xv Chapter 1: Introduction . 1 1.1 Overview . 1 1.2 Natriuretic Peptides . 5 NP Synthesis and Processing . 6 NP Metabolism, Clearance and Degradation . 8 1.3 Natriuretic Peptide Receptors . 9 Natriuretic Peptide Receptor – A/B . 9 Natriuretic Peptide Receptor – C . 14 1.4 Natriuretic peptides, cAMP, cGMP and Phosphodiesterases . 15 1.5 Physiological effects of NPs . 19 Effects on Blood Pressure . 19 Effects on the Heart . 20 Other Non-Cardiac Effects of BNP . 22 1.6 Pathologies Associated with NPs/NPRs . 24 1.7 Purpose and Hypothesis . 25 Chapter 2: Materials and Methods . 27
What affects university image and students’ supportive attitudes: the 4Q Model

ABSTRACT The purpose of this study is to understand the factors affecting a university’s image and students’ supportive attitudes. To this end, we have developed a new model, named the 4Q Model. Previous studies have already proposed a number of factors affecting university image. However, in this study, we simplified the factors into four main titles which are quality of academics, quality of education, quality of research, and quality of physical conditions. Our model tests the influence of this ‘4Q’ on university image. We also examined the effect of university image on students’ supportive attitudes. The model was validated through structural equation modelling based on surveys of 427 university students. The results show that quality of academics, quality of education, quality of research, and quality of physical conditions all have a positive impact on university image. In particular, the quality of research is the most important key driver impacting the university image. We also found that university image has a strong impact on students’ supportive attitudes. Theoretical and managerial implications are also discussed as recommendations for future research.
Low-Energy Optical Conductivity of TaP: Comparison of Theory and Experiment

The ab-plane optical conductivity of the Weyl semimetal TaP is calculated from the band structure and compared to the experimental data. The overall agreement between theory and experiment is found to be best when the Fermi level is slightly (20 to 60 meV) shifted upwards in the calculations. This confirms a small unintentional doping of TaP, reported earlier, and allows a natural explanation of the strong low-energy (50 meV) peak seen in the experimental ab-plane optical conductivity: this peak originates from transitions between the almost parallel non-degenerate electronic bands split by spin-orbit coupling. The temperature evolution of the peak can be reasonably well reproduce by calculations using an analog of the Mott formula.
Generalizability of pediatric major trauma experience to severe pediatric traumatic brain injury at level 1 and 2 trauma centers

Background: To examine the volume-outcome relationship in severe pediatric traumatic brain injury (TBI) using a retrospective analysis and to determine whether volume as a measure of broader trauma experience may generalize to favor improved pediatric TBI outcomes. Methods: We isolated all pediatric admissions for severe TBI (GCS admission score 3–8) to Pediatric ACS Level I and II Trauma Centers in the 2012–2015 National Trauma Data Bank. Using multivariate regression analysis, we examined the impact of four distinct volume variables—pediatric severe TBI, pediatric major trauma, adult severe TBI, and adult major trauma—on severe pediatric TBI short-term outcomes. Each volume measure was analyzed continuously as a primary independent variable. Our primary outcome variable was hospital discharge disposition. We adjusted for patient demographics, hospital characteristics, trauma severity metrics, and field-to-hospital time. Results: A total of 5,425 severe pediatric TBI patients were included in the final study population. Following multivariate analysis, only higher pediatric major trauma volume was associated with higher odds of favorable discharge [OR =1.073, 95% CI: (1.033, 1.114) per +100 patients, P<0.001]. Major pediatric trauma volume was also associated with shorter hospital ( ‒ 0.21 days per +100 patients, P=0.035) and ICU LOS ( ‒ 0.16 days per +100 patients, P=0.011). Both pediatric trauma and TBI volume were correlated with lower complication rates [Major Pediatric Trauma: OR =0.956, (0.921, 0.992) per +100 patients, P=0.018; Severe Pediatric TBI: OR =0.824, (0.728, 0.933) per +100 patients, P=0.002], particularly ARDS [Major Pediatric Trauma: OR =0.851, (0.783, 0.924) per +100 patients, P<0.001, Severe Pediatric TBI: OR =0.505, (0.372, 0.684) per +100 patients, P<0.001]. Conclusions: Among four different volume metrics, pediatric major trauma volume was correlated with more favorable discharge. General pediatric trauma experience was also associated with lower complication rates, particularly ARDS. An institution’s adult trauma and TBI experience did not significantly influence severe pediatric TBI outcomes. 17
Protocatechuic acid as an inhibitor of the JNK/CXCL1/CXCR2 pathway relieves neuropathic pain in chronic constriction injury rats

Emerging evidence has shown that protocatechuic acid (PCA) has antioxidant and anti-inflammatory effects. Evidence suggests that PCA can alleviate the injury of sciatic nerve, while the mechanism of its therapeutic effect on neuralgia remains unknown. Chromium bowel ligation was used in vivo to establish a chronic constriction injury (CCI) rat model to induce sciatic nerve pain. Subsequently, two doses of PCA were used to treat CCI rats. In vitro, 10 ng/mL tumor necrosis factor-α (TNF-α) was used to stimulate glial satellite cells derived from the dorsal root ganglia (DRG) L4-L6 of the sciatic nerve to simulate sciatic nerve pain. PCA relieved mechanical allodynia and thermal hyperalgesia in CCI rats. CCK-8 assay revealed that PCA inhibited the proliferation of glial satellite cells induced by TNF-α. Moreover, enzyme-linked immunosorbent assay demonstrated that PCA could improve the inflammatory response of rats caused by CCI and cells induced by TNF-α. Next, reverse transcription quantitative polymerase chain reaction and Western blot assays showed that PCA blocked the c-Jun N-terminal kinase/the chemokine ligand 1/CXC chemokine receptor 2 (JNK/CXCL1/CXCR2) pathway by inhibiting CXCL1 levels in cells induced by TNF-α and DRG in CCI rats. In conclusion, PCA can alleviate neuropathic pain in CCI rats and improve oxidative stress by inhibiting the JNK/CXCL1/CXCR2 signaling pathway. Thus, these findings provide a new perspective for the treatment of neuropathic pain caused by CCI.