Miracle-dz/UniFAR-FTUs huggingface dataset:
Characteristics of COVID-19 Inpatients in Rehabilitation Units during the First Pandemic Wave: A Cohort Study from a Large Hospital in Champagne Region

Simple Summary Analyzing how healthcare institutions adapted to the first wave of the COVID-19 pandemic will make it possible to better prepare for future crises. Analyzing the characteristics of patients admitted to rehabilitation units during the first wave makes it possible to better understand rehabilitation needs during a pandemic crisis. The characteristics of all patients admitted to a single, large university hospital in Northeast France for SARS-CoV-2 infection during this period are described. The initial severity of infection and advanced age were associated with referral to inpatient rehabilitation units. The proportion of patients who had access to inpatient rehabilitation units was lower than expected in this study, which raises questions about the deployment of rehabilitation services. The availability and organization of rehabilitation plans in acute care units and post-acute care are key elements to anticipate in the event of a pandemic crisis. Abstract Background: Data describing patients hospitalized in medical rehabilitation wards after the acute phase of COVID-19 could help to better understand the rehabilitation needs in the current pandemic situation. Methods: Cohort including all patients with COVID-19 hospitalized in a single, large university hospital in Northeast France from 25 February to 30 April 2020. Results: 479 patients were admitted with COVID-19 during the study period, of whom 128 died (26.7%). Among the 351 survivors, 111 were referred to rehabilitation units, including 63 (17.9%) referred to physical and rehabilitation medicine (PRM) units. The median age of patients referred to rehabilitation units was 72 years. Patients who had been in intensive care, or who had had a long hospital stay, required referral to PRM units. Two biomarkers were associated with referral to rehabilitation units, namely, elevated troponin (p = 0.03) and impaired renal function (p = 0.03). Age was associated with referral to PRM units (p = 0.001). Conclusions: Almost one-third of COVID-19 patients required post-acute care, but only one-fifth had access to PRM units. The optimal strategy for post-acute management of COVID-19 patients remains to be determined. The need for rehabilitation wards during a pandemic is a primary concern in enabling the long-term functioning of infected patients.
Comparison of Shoulder Total Rotational Range of Motion and External to Internal Rotation Strength Ratio between Assembly Line Workers with and without Subacromial Pain Syndrome

Background Subacromial pain syndrome (SAPS) is one of the causes of shoulder pain in workers performing repetitive upper extremity movements. However, there have been no studies on physical characteristics such as shoulder total rotational range of motion (ROM) and external to internal rotation muscle strength ratio of workers. Purpose The purpose of this study was to compare the total rotational ROM and external to internal rotation muscle strength ratio in workers with and without SAPS. Study design A cross-sectional study Methods This study included 35 workers with SAPS and 32 workers without SAPS. The total rotational ROM were measured using Smart KEMA motion sensor, and external to internal rotation muscle strength were measured using Smart KEMA pulling sensor. Results The results showed that there were significant differences in the total rotation ROM between the groups ( p <0.05). However, no significant difference was found in the external to internal rotation muscle strength ratio ( p >0.05). Conclusions Assembly line workers with SAPS had limited total rotational ROM. However, the ratio of external to internal rotation muscle strength ratio was not different for workers without SAPS. These characteristics can be considered factors that should be considered in evaluating workers with SAPS and establishing a treatment plan.
Barriers From Third-Party Payers to Biologic Use in Pediatric Inflammatory Bowel Disease

Biologic agents are now standard of care in the treatment of inflammatory bowel disease (IBD). The ability to use biologics in clinical practice is in part dictated by insurance company policies. There is a long delay between adult and pediatric approval of biologic agents, and these therapies are often denied by third-party payers for use in pediatric IBD patients. This study prospectively identified pediatric patients with IBD who were started on a biologic medication at our institution, and third-party payer decisions were recorded. There were no denials in patients with Medicaid, but private payers frequently interfered with use of biologic agents. Reasons for denial are generally for use of a specific off-label agent or dosing of an approved agent. These denials lead to delayed treatment, nonmedically sound changes in therapy, and increased administrative burden on providers.
Implementation Strategies For Real-time Traffic Safety Improvements On Urban Freeways

This research evaluates Intelligent Transportation System (ITS) implementation strategies to improve the safety of a freeway once a potential of a crash is detected. Among these strategies are Variable Speed Limit (VSL) and ramp metering. VSL are ITS devices that are commonly used to calm traffic in an attempt to relieve congestion and enhance throughput. With proper use, VSL can be more cost effective than adding more lanes. In addition to maximizing the capacity of a roadway, a different aspect of VSL can be realized by the potential of improving traffic safety. Through the use of multiple microscopic traffic simulations, best practices can be determined, and a final recommendation can be made. Ramp metering is a method to control the amount of traffic flow entering from on-ramps to achieve a better efficiency of the freeway. It can also have a potential benefit in improving the safety of the freeway. This thesis pursues the goal of a best-case implementation of VSL. Two loading scenarios, a fully loaded case (90% of ramp maximums) and an off-peak loading case (60% of ramp maximums), at multiple stations with multiple implementation methods are strategically attempted until a best-case implementation is found. The final recommendation for the off-peak loading is a 15 mph speed reduction for 2 miles upstream and a 15 mph increase in speed for the 2 miles downstream of the detector that shows a high crash potential. The speed change is to be implemented in 5 mph increments every 10 minutes. The recommended case is found to reduce relative crash potential from . 065 to -. 292, as measured by a high-speed crash prediction algorithm (Abdel-Aty et al. 2005). A possibility of crash migration to downstream and
Inquiry Into Physicians’ Scope of Practice in Japanese Rural Hospitals During the COVID-19 Pandemic: A Serial Cross-Sectional Study

Introduction Physicians' scope of practice (SoP) depends on clinical settings and is related to how motivated they feel. The clarification and differences in the SoP in each clinical setting are necessary for physicians’ careers. This study aimed to investigate how coronavirus disease 2019 (COVID-19) affected physicians’ SoP. Methods This serial cross-sectional study compares the differences in physicians’ SoP among Japanese rural community hospitals between 2018 and 2020. The participants were admitted patients in the internal medicine wards of the two community hospitals in urban and rural districts in the rural prefecture (Shimane) of Japan from January 1, 2018, to December 31, 2020. We calculated the number of health problems among the highest 50% of all health problems for each physician (SoP-50%) and used it as an indicator of the comprehensiveness of clinical practice. Results The study found that SoP-50% was significantly higher in rural districts in 2018 (p = 0.0209). This trend remained unchanged even during the COVID-19 in 2020 (p = 0.0441). While there was a significant regional difference in the SoP, pre and post-COVID-19 analysis of the SoP in each region did not show any significant change. Conclusion This is the first study to indicate that greater comprehensiveness of clinical practice is required in the districts of rural Japan. The findings can be helpful for physicians’ medical education and career choices.
Synergistic effect of obeticholic acid and fasting-mimicking on proliferative, migration, and survival signaling in prostate cancer

The systemic and resistant nature of the androgen-independent stage of prostate cancers makes it largely incurable even after intensive multimodal therapy. Apoptosis and epithelial-mesenchymal transition (EMT) are two fundamental events that are deeply linked to carcinogenesis. Hence, it is necessary to find a new combination of several therapies targeting apoptosis and EMT without causing side effects. Several recent studies have indicated that the Farnesoid X receptor is extensively associated with human tumorigenesis. The FXR agonist obeticholic acid (INT 747) has preliminarily exhibited a tumor suppressor potential. In this present study, we assess the potential synergism of FXR activation under nutrient deprivation in prostate cancer cell lines to investigate whether FXR activation enhances starvation-induced apoptosis in PC3 cells. In this study, PC-3 treatment with INT 747 significantly repressed cell proliferation and clonogenic potential. In addition, it significantly induced apoptosis of PC-3 cells and decreased their cancerogenic potential, as evaluated by annexin v apoptosis and transwell migration assay, respectively. The decreased expression of pro-caspase 3 by western blot analysis further confirmed INT 747-induced apoptosis. Furthermore, the fasting-mimicking diet (FMD) potentiated the antiproliferative, pro-apoptotic, and antimetastatic effects of INT 747. Mechanistically, these effects were mediated through the downregulation of cyclin D1 and upregulation of PTEN. In conclusion, INT 747 alone markedly decreases, and when combined with FMD abrogates the growth and migration of PC-3 cells.
Shortening the Return-to-Play Times in Elite Athletes With Unstable Isolated Lisfranc Ligament Injuries Using a Knotless Interosseous Suture Button: Case Series and Literature Review

Background: Isolated unstable Lisfranc ligament injuries in elite athletes are associated with a lengthy period of rehabilitation and prolonged absence from competition. Purpose: To assess the efficacy of a knotless, interosseous suture button system for repairing isolated unstable ligamentous Lisfranc injuries and its capacity to allow accelerated rehabilitation with earlier weightbearing and return-to-play times in elite athletes. Study Design: Case series; Level of evidence, 4. Methods: The authors retrospectively reviewed data from a prospectively compiled database for elite athletes treated by a single surgeon. All included patients had clinical and magnetic resonance imaging evidence of an unstable isolated complete ligamentous Lisfranc injury requiring surgical reduction and stabilization. All patients underwent surgery using a knotless interosseous suture button to achieve stabilization, followed by a standardized postoperative regimen involving full weightbearing at 4 weeks, and all had a minimum postoperative follow-up of 2 years. Results: Included were 12 patients: 7 National Rugby League (NRL) players, 2 professional dancers, 1 Olympic gymnast, 1 professional wakeboarder, and 1 professional NRL referee. The mean age of the patients was 21.1 years (range, 16-34 years). Ten patients underwent acute surgical stabilization within 3 weeks of the injury, and 2 patients sustained chronic isolated Lisfranc instability that was initially treated nonoperatively. All athletes were able to return to full weightbearing by 4 weeks postoperatively, successfully returned to training by 9 to 12 weeks, and returned to full competition by 12 to 16 weeks. No major complications were reported. Conclusion: Knotless interosseous suture button stabilization was a reliable treatment option for both acute and chronic isolated ligamentous Lisfranc injuries in these elite athletes. This technique does not require hardware removal, allows early weightbearing with accelerated rehabilitation, and may shorten the return-to-play interval.
The value relevance of the revenue from contracts with customers standard (IFRS 15) and management motives: an empirical examination on Jordanian industrial companies

The study aims to evaluate the feasibility of applying IFRS 15 to improve the quality of accounting information. This improvement can be achieved via its relevance to investors’ decisions in the financial market and by testing two hypotheses. The first one shows the different ranges in Value-Relevance for revenue pre and post-application IFRS 15. The second attempts to know the difference in the management’s motives on the soothing revenue process pre and post the standard application. The quantitative analysis method uses the multiple regression analysis models for some companies in the Jordanian industrial sector. The study sample consists of 39 industrial companies registered in the Amman Stock Exchange for the first two periods from 2014-to 2016, while the second is from 2017 to 2019. The first period represents the period before the application of IFRS 15. In contrast, the second period represents the standard application period, whereas the second period represents the period of the standard application. The statistical analysis results indicate a decrease in the revenue response factor after the application of IFRS 15 and that its application did not undermine the management’s interventions in the practice of soothing revenue.
Evaluation of perturbed iron-homeostasis in a prospective cohort of patients with COVID-19

Background: Marked reductions in serum iron concentrations are commonly induced during the acute phase of infection. This phenomenon, termed hypoferremia of inflammation, leads to inflammatory anemia, but could also have broader pathophysiological implications. In patients with coronavirus disease 2019 (COVID-19), hypoferremia is associated with disease severity and poorer outcomes, although there are few reported cohorts. Methods: In this study, we leverage a well characterised prospective cohort of hospitalised COVID-19 patients and perform a set of analyses focussing on iron and related biomarkers and both acute severity of COVID-19 and longer-term symptomatology. Results: We observed no associations between acute serum iron and long-term outcomes (including fatigue, breathlessness or quality of life); however, lower haemoglobin was associated with poorer quality of life. We also quantified iron homeostasis associated parameters, demonstrating that among 50 circulating mediators of inflammation IL-6 concentrations were strongly associated with serum iron, consistent with its central role in inflammatory control of iron homeostasis. Surprisingly, we observed no association between serum hepcidin and serum iron concentrations. We also observed elevated erythroferrone concentrations in COVID-19 patients with anaemia of inflammation. Conclusions: These results enhance our understanding of the regulation and pathophysiological consequences of disturbed iron homeostasis during SARS-CoV-2 infection.
A Comprehensive Meta-Analyses of the Nomological Network of Psychological Capital (PsyCap)

This paper presents the most rigorous meta-analysis undertaken to date of empirical literature examining antecedents and outcomes related to psychological capital (PsyCap), and moderators of these relationships. We investigated seven leadership styles as antecedents of PsyCap (authentic, ethical, servant, empowering, transactional, transformational, and abusive leadership), five outcomes (burnout, turnover intentions, work engagement, performance, and satisfaction), and the impact of four moderators (country of sample origin, cultural characteristics, industry type, and research design). Our analysis of PsyCap research (2007–2020) examined 244 studies (254 independent samples and over 96000 participants), which is over twice as large as previous PsyCap meta-analyses. To optimize the quality and reliability of findings, we corrected for artefacts and included heterogeneity, sensitivity, and publication bias analyses. Our results provide several new findings beyond previous PsyCap meta-analyses. We found that empowering, servant, transformational, and transactional leadership were all positively associated with PsyCap, with empowering and transformational leadership being the strongest antecedents of PsyCap and abusive and transactional leadership being the weakest. The findings demonstrated PsyCap was positively associated with work engagement, and negatively associated with burnout. Country of sample origin moderated all the relationships, except for servant and transactional leadership. Additionally, cultural characteristics (e.g., power distance, masculinity, long-term orientation, and uncertainty avoidance) moderated several conceptual relationships. Study design was also found to moderate the PsyCap—work engagement relationship. Collectively, these findings offer new and extended insights into the antecedents, outcomes, and moderators related to PsyCap, beyond previous meta-analyses. The theoretical and practical implications of these new findings are also discussed.
Hodgkin Lymphoma: Biology and Differential Diagnostic Problem

Hodgkin lymphomas (HLs) are lymphoid neoplasms that are morphologically defined as being composed of dysplastic cells, namely, Hodgkin and Reed–Sternberg cells, in a reactive inflammatory background. The biological nature of HLs has long been unclear; however, our understanding of HL-related genetics and tumor microenvironment interactions is rapidly expanding. For example, cell surface overexpression of programmed cell death 1 ligand 1 (CD274/PD-L1) is now considered a defining feature of an HL subset, and targeting such immune checkpoint molecules is a promising therapeutic option. Still, HLs comprise multiple disease subtypes, and some HL features may overlap with its morphological mimics, posing challenging diagnostic and therapeutic problems. In this review, we summarize the recent advances in understanding the biology of HLs, and discuss approaches to differentiating HL and its mimics.
Start-Up’s Road to Disruptive Innovation in the Digital Era: The Interplay Between Dynamic Capabilities and Business Model Innovation

The emergence and infusion of digital technologies bring greater chances for start-ups to conduct disruptive innovation through digital entrepreneurship. Despite the existed business practices, the happening mechanism of start-up’s disruptive innovation in the digital economy context remains unclear. This study aims to understand the evolutionary mechanism and fulfillment path start-ups’ disruptive innovation in the digital era. The longitudinal case study is conducted for a Chinese Internet start-up that successfully launched disruptive innovation under the digital economy background. Adopting a process perspective, this study analyzes the evolutionary phases of digital disruptive innovation. Moreover, this study identifies the digital technologies adoption, dynamic capabilities deployment, and business model innovation as the key pillars, and their interactions. Finally, this study induces and proposes its evolution mechanism and fulfillment path models. This study enriches the research scope of disruptive innovation and digital entrepreneurship. This study can offer theoretical guidance for the start-ups’ disruptive innovation in the digital era, and practical implications for implementing a digital catching-up strategy.
Financial Constraints, Debt Capacity, and the Cross Section of Stock Returns in Nepalese Listed Non-Financial Firms

This study aims to determine whether debt capacity holds differential impact in the cross section of stock return for financial constrained and financial unconstrained Nepalese enterprises. Considering listed non-financial firm as population, study collect quantitative nature of 10 year balanced panel data from 11 nonfinancial firms listed in Nepal Stock Exchange (NEPSE) and actively traded during the period of 2008 to 2018. Data were obtained by using secondary source. As per propose of the study firm has been categorized financial constrained and financial unconstrained using the basis of book value of assets. Obtained data were analyzed by using multivariate econometric model. Study found that market value of equity, book to market ratio, and debt capacity are major explanatory variables of stock returns for financially constrained firms. Study further found that debt capacity has positive significant impact on stock returns for financial constrained firms. However, with regard to financial unconstrained firm’s debt capacity impact on stock return is insignificant. Study concluded that debt capacity hold differential impact in the cross section of stock returns in Nepalese nonfinancial firms.
Social media engagement and crowdfunding performance: The moderating role of product type and entrepreneurs' characteristics

Entrepreneurs are showing an increasing focus on understanding and managing their social media strategies to optimize the success of their crowdfunding campaigns. While much of the current crowdfunding literature focuses on the roles of social media engagement in the funding performance of crowdfunded projects, in this study, drawing on social media engagement theory, we examine how product and entrepreneur characteristics moderate the influence of social media engagement on funding performance in the reward‐based crowdfunding. Using a dataset of technology crowdfunded projects, we investigated whether Facebook and Twitter engagements affect funding outcomes and if so, how the two interact with each other and their influences vary by project type (hardware and software) and entrepreneur characteristics (gender, experience, and social capital). We found that both Facebook and Twitter engagements positively affect funding, but the two weaken each other's impact, particularly for hardware products. Additionally, Facebook engagements had a larger effect on funding outcomes in the early days of a campaign driven by its prelaunch efforts, whereas Twitter engagements had a larger impact in later days. Furthermore, our findings indicated that Facebook engagement is more influential for hardware products. An entrepreneur's internal social capital built inside the crowdfunding platform also weakened the effects of Facebook engagements generated outside the platform, whereas Twitter engagements on subsequent funding had less influence on experienced entrepreneurs. Our findings suggest that Facebook mainly serves as a channel to show the significant commitment of entrepreneurs to their projects and increase persuasiveness, while Twitter helps to raise awareness by broadcasting crowdfunding campaigns among potential investors.