Miracle-dz/UniFAR-FTUs huggingface dataset:
Development of Depressive Symptoms after Myocardial Infarction-Impact of Risk Factors

Aim: We designed this study to compare the presence of depressive symptoms pre and 6 months post-MI and to identify the association of various biological and non-biological risk factors with the development of depressive symptoms post-MI. Objective: Coronary artery disease and depressive illness are the largest contributors to global mortality and disability. These disorders frequently occur together and have major health implications. We conducted this study to determine the frequency of increased depressive symptoms following Myocardial Infarction (MI) and analyze associated baseline risk factors. Study Design: Descriptive case series. Place and duration of study: Tertiary care cardiology hospital from Sept 2019 to Jan 2021. Patients and Methods: Patients presenting with a recent episode of myocardial infarction at the out-patient department of cardiology were recruited for this study. Demographic variables and baseline health status were recorded. Hospital Anxiety and Depression Scale (HADS) was applied in two instances,
Characterization of ncf1 Mutants in a Zebrafish Model of Innate Immune Function with Human Influenza A Virus Infection

Seasonal influenza A virus (IAV) infections and their associated respiratory diseases are the cause of an estimated 650,000 deaths each year, according to the World Health Organization. The zebrafish (Danio rerio) is a powerful vertebrate model to study innate immune function and host-pathogen interactions as the function of neutrophils and other phagocytes can be characterized in vivo. Preliminary studies have shown an increase in neutrophil respiratory burst activity to eliminate the invading pathogen, yet little is known of all of the mechanisms involved in neutrophil function. The NADPH oxidase complex, of which neutrophil cytosolic factor 1 (Ncf1) is a key component, regulates reactive oxygen species (ROS) to control neutrophil response to viral infection. Although necessary to fight infection, this elicits a hyperinflammatory response that can damage the infected host epithelial tissue, leaving high-risk individuals with increased mortality rates. Our hypothesis is that a fully functional Ncf1 protein is required for neutrophil function, but morpholino knockdown of the gene will limit the amount of damaging ROS hyperinflammation in host tissue. Our preliminary studies of systemic IAV infected embryos indicate that the survival of ncf1 morphants was increased compared to standard morphant control groups. Fluorescence confocal imaging and TCID50 assays reveal a decreased viral burden in ncf1 morphant groups compared to control morphant groups over a span of 96 hours post-infection. Finally, qRT-PCR studies assay the expression of nrf2, mxa, and cxcl8b revealing decreased expression of each gene in ncf1 morphants compared to controls. These studies aim to increase our understanding of neutrophil function that may eventually lead to new therapies for treating IAV infection.
A Additional Implementation Details

We implement MOSS using JAX [1], Haiku [4]. We chose to build on top of JAX [1] as we observed a 2x speedup compared to PyTorch [8]. Moreover, we use PyTorch [8] and Reverb [2] to implement the replay buffer. Tab. 1 details the hyper-parameters used in MOSS which are taken directly from CIC [6]. Since MOSS builds on CIC [6], we empirically verified that our implementation on top of JAX [1] matches the performance on top of PyTorch [8].
Thèse pour le Doctorat ès Sciences Economiques

This work aims to contribute to the analysis of French Internet based labour markets. This empirical field has hardly been explored by studies assessing the economic and social impacts of the Internet. More precisely, my study explores how the new media transforms the format of interaction and modes of evaluation in the labour market. Understanding these changes requires to complete information search costs analyses with an examination of the role of quality and qualification in the coordination process. First, I discuss the potential of the Internet to reduce frictions in the labour market. In theory, a decrease in search costs should lead to an improvement of the agregate matching process; however, empirical evidence does not confirm such predictions. This result leads me to focus on Internet based labour market intermediaries. The theory of industrial organization is used to consider the strategic interactions between intermediaries. I show that network externalities and quality uncertainty, which play a decisive role in the structuring process of Internet labour markets, generate friction. Secondly, I investigate the way coordination technologies built by intermediaries help reduce uncertainty on both sides of the labour market. With empirical evidence grounded on a statistical analysis of queries made on a French job ads’ search engine, I show that the Internet reduces uncertainty if and only if information is organised and structured. Yet, coordination technologies – whose role consists in structuring information and framing information flows – are not ‘neutral’ since they embody modes of qualification and evaluation. I examine this issue, which is related to the institutions of the labor market. I elaborate an analytical framework which accounts for the plurality of electronic intermediation forms by investigating the required investments to establish and stabilize a coordination technology. Mots-clés – technologies de l’information et de la communication / Internet / marché du travail / intermédiaires / information / incertitude / coordination / qualification / évaluation EconomiX UMR CNRS 7166 Université de Paris X-Nenterre, 200, avenue de la République, 92001 Nanterre Cedex te l-0 00 90 29 8, v er si on 1 29 A ug 2 00 6
Early Identification of Successful and Unsuccessful Students in the First Year at the University

Purpose: To investigate how well at an early stage, based on preand post-enrolment data, students could be identified who become successful and unsuccessful in the first year at the university. Method: Based on pre-and post-enrolment data, 24,976 students of the cohorts 2009e2015 were divided in subgroups. For each subgroup the percentage of successful, delayed, and unsuccessful students at the end of the first year was determined. Results: Based on only the pre-enrolment data, i.e. sex, ethnic background, and type and level of achievement during the final examinations of pre-university education, on the one hand subgroups of students with a 74e82% success rate and a 5e10% dropout rate could be identified. On the other hand, subgroups with only a ≤35% success rate and an almost 50% dropout rate. By adding post-enrolment data, i.e. the achievement of students at the first two exams in the university, subgroups with a ≥90% success rate and a ≤5% dropout rate could be identified, and subgroups with only a ≤10% success rate and a ≥70% dropout rate. Discussion: It is possible to identify successful and unsuccessful students at a very early stage. The challenge for the future is to investigate what appropriate interventions can be developed for (a) students who already before the start of their academic career or very early after the start at the university have a high chance of becoming unsuccessful and for (b) those who have a high chance of becoming successful.
Importance of Permafrost Wetlands as Dissolved Iron Source for Rivers in the Amur-Mid Basin

Dissolved iron (dFe) transported by the Amur River greatly contributes to phytoplankton growth in the Sea of Okhotsk. Nevertheless, there has been little research on the dFe source of rivers, especially in the Amur-Mid Basin which is situated in a sporadic permafrost area. In the Amur-Mid Basin, permafrost generally exists under wetlands in the ﬂat valley, and these permafrost wetlands could be a dFe source of rivers. To asess the importance of the permafrost wetlands as a dFe source, ﬁrst we made a landcover map with high resolution of 30 m using Landsat-8 data and a machine learning technique (decision tree analysis). As a result of decision tree analysis, three normalized indices (normalized diference vegetation index, normalized diﬀerence soil index, and normalized diﬀerence water index) and slope enabled us to classify landcovers into three vegetation types: wetland, forest, and grassland. Using this landcover map, we investigated the coverages of the permafrost wetland in the sampled watersheds and examined the correlation with river water chemistry (dFe, dissolved organice carbon: DOC, and electrical conductivity: EC). As a result, dFe and DOC concentrations showed a clear positive correlation (dFe: r2 = 0.66, DOC: r2 = 0.46) with the coverage of permafrost wetlands, while EC showed a negative correlation with those (r2 = 0.45). These ﬁndings are the ﬁrst to demonstrate the direct evidence about the importance of permafrost wetlands to supply dFe and DOC to rivers in the Amur-Mid Basin.
Risk factors for severe complications and mortality in hospitalized children with measles during a major outbreak in Northern Vietnam, 2017 - 2019

Introduction: Measles outbreaks increased worldwide during the period of 2017-19. Similarly, Vietnam experienced one of the largest measles outbreaks in recent decades, with various paediatric patients presenting severe complications. In this study, we aim to identify factors associated with death and severity among children with measles admitted to Vietnam National Children's Hospital between 2017 and 2019. Method: This single-center retrospective cohort study included 2072 patients with measles admitted from 1/1/2017 to 31/12/2019. Data on epidemiological, clinical characteristics, vaccine status, and outcomes were collected and summarised. We conducted both univariable and multivariable logistic regression analyses to examine the correlations between various characteristics of hospitalized children and mortality. Findings: In total, there were 2072 patients, including 1297 (62.6%) males and 775 (37.4%) females. The median age was 9 months (interquartile range 7 - 17). 87.3% of cases were reported not to have received any MCV. 30 (1.4%) patients died, with 40% aged less than 9 months. Only 3 among 30 (10%) children had received at least 1 dose of MCV deceased. Pneumonia bronchitis was the most common complication, occurring in 1413 (68.2%) patients. The following characteristics were significantly associated with mortality in the multivariable analysis: age under 9 months and age from 9 months to 5 years, residing 20 to 200 kilometres from VNCH, and having adenovirus or other healthcare-related infections. Age group was also significantly associated with severity in the multivariable analysis. Interpretation: Vietnam continues to face the threat of future measles epidemics, given the burden of hospitalization and the high rate of complications observed in hospitalized patients. This highlights the critical need to maintain high measles vaccine coverage, particularly by targeting the unvaccinated population. To prevent future outbreaks and lower measles incidence, routine immunization needs to be strengthened, and earlier scheduling of MCV1 needs to be further evaluated. The comprehensive analysis of the 2017-19 measles outbreak presented in this study will contribute to informed decision-making regarding appropriate measures to counteract future resurgences of measles in Vietnam. Funding: No specific grant from funding agencies in the public, commercial or not-for-profit sectors supported the submission and publication of this manuscript.
Why is there a gap in self-rated health among people with hypertension? A decomposition of determinants and rural‒urban differences

Abstract Background Hypertension affects over one billion people globally and is one of the leading causes of premature death. The low- and middle-income countries, especially the sub-Saharan Africa region, bear a disproportionately higher share of hypertension globally. Recent evidence shows a steady shift in the burden of hypertension from the more affluent and urban population towards the poorer and rural communities. Our study examined inequalities in self-rated health among people with hypertension and whether there is a rural‒urban gap in the health of these patients. We then quantified factors driving the health gap. We also examined how much HIV accounts for differences in self-rated health among hypertension patients due to the relationship between HIV, hypertension and health in sub-Saharan Africa. Methods We utilized the Zambia Household Health Expenditure and Utilization Survey for the data on SRH and other demographic and socioeconomic controls. District HIV prevalence information was from a previous study. The linear probability model provided a preliminary assessment of the association between self-rated health and independent variables. We then used the Blinder-Oaxaca decomposition to identify self-rated health inequality between urban and rural patients and determine determinants of the health gap between the two groups. Results Advanced age, lower education and low district HIV prevalence were significantly associated with poor health rating among hypertension patients. The decomposition analysis indicated that 45.5% of urban patients and 36.9% of rural patients reported good self-rated health, representing a statistically significant health gap of 8.6%. Most of the identified health gap can be attributed to endowment effects, with education (62%), district HIV prevalence (26%) and household expenditure (12%) being the most important determinants that explain the health gap. Conclusions Urban hypertension patients have better SRH than rural patients in Zambia. Educational interventions, financial protection schemes and strengthening hypertension health services in rural areas can significantly reduce the health gap between the two regions.
Apoer2-ICD-dependent regulation of hippocampal ribosome mRNA loading

Abstract Background ApoE4, the most significant genetic risk factor for late-onset Alzheimer’s disease (AD), sequesters a pro-synaptogenic Reelin receptor, Apoer2, in the endosomal compartment and prevents its normal recycling. In the adult brain, Reelin potentiates excitatory synapses and thereby protects against amyloid-β toxicity. Recently, a gain-of-function mutation in Reelin that is protective against early-onset AD has been described. Alternative splicing of the Apoer2 intracellular domain (Apoer2-ICD) regulates Apoer2 signaling. Splicing of juxtamembraneous exon 16 alters the g-secretase mediated release of the Apoer2-ICD as well as synapse number and LTP, and inclusion of exon 19 ameliorates behavioral deficits in an AD mouse model. The Apoer2-ICD has also been shown to alter transcription of synaptic genes. However, the role of Apoer2 splicing for transcriptional regulation and its role in AD pathogenesis is unknown. Methods To assess in vivo mRNA-primed ribosomes specifically in hippocampi transduced with Apoer2-ICD splice variants, we crossed wild-type, cKO, and Apoer2 cleavage-resistant mice to a Cre-inducible translating ribosome affinity purification (TRAP) model. This allowed us to perform RNA-Seq on ribosome-loaded mRNA harvested specifically from hippocampal cells transduced with Apoer2-ICDs. Results Across all conditions, we observed ~ 4,700 altered ribosome-associated transcripts, several of which comprise key synaptic components such as extracellular matrix and focal adhesions with concomitant perturbation of critical signaling cascades, energy metabolism, translation, and apoptosis. We further demonstrated the ability of the Apoer2-ICD to rescue many of these altered transcripts, underscoring the importance of Apoer2 splicing in synaptic homeostasis. A variety of these altered genes have been implicated in AD, demonstrating how dysregulated Apoer2 splicing may contribute to neurodegeneration. Conclusions Our findings demonstrate how alternative splicing of the APOE and Reelin receptor Apoer2 and release of the Apoer2-ICD regulates numerous ribosome-associated transcripts in mouse hippocampi in vivo . These transcripts comprise a wide range of functions, and alterations in these transcripts suggest a mechanistic basis for the synaptic deficits seen in Apoer2 mutant mice and AD patients. Our findings, together with the recently reported AD-protective effects of a Reelin gain-of-function mutation in the presence of an early-onset AD mutation in Presenilin-1, implicate the Reelin/Apoer2 pathway as a target for AD therapeutics.
Solvability of degenerated parabolic equations without sign condition and three unbounded nonlinearities.

In this article, we study the problem ∂ ∂t b(x, u)− div(a(x, t, u, Du)) + H(x, t, u, Du) = f in Ω×]0, T [, b(x, u)(t = 0) = b(x, u0) in Ω, u = 0 in ∂Ω×]0, T [ in the framework of weighted Sobolev spaces, with b(x, u) unbounded function on u. The main contribution of our work is to prove the existence of a renormalized solution without the sign condition and the coercivity condition on H(x, t, u, Du). The critical growth condition on H is with respect to Du and no growth condition with respect to u. The second term f belongs to L1(Q), and b(x, u0) ∈ L1(Ω).
Structure of a transmission blocking antibody in complex with Outer surface protein A from the Lyme disease spirochete, Borreliella burgdorferi

319‐44 is a human monoclonal antibody capable of passively protecting mice against tick‐mediated infection with Borreliella burgdorferi, the bacterial genospecies responsible for Lyme disease in North America. In vitro, 319‐44 has complement‐dependent borreliacidal activity and spirochete agglutinating properties. Here, we report the 2.2 Å‐resolution crystal structure of 319‐44 Fab fragments in complex with Outer surface protein A (OspA), the ~30 kDa lipoprotein that was the basis of the first‐generation Lyme disease vaccine approved in the United States. The 319‐44 epitope is focused on OspA β‐strands 19, 20, and 21, and the loops between β‐strands 16‐17, 18‐19, and 20‐21. Contact with loop 20‐21 explains competition with LA‐2, the murine monoclonal antibody used to estimate serum borreliacidal activities in the first‐generation Lyme disease vaccine clinical trials. A high‐resolution B‐cell epitope map of OspA will accelerate structure‐based design of second generation OspA‐based vaccines.
Evaluation of driving fitness using driving simulators in patients with right-hemisphere damage: an unmatched case-control study

ABSTRACT Background Patients with right hemisphere damage (RHD) may exhibit mild unilateral spatial neglect (USN), which is difficult to detect in general assessments performed during driving rehabilitation. Objectives We compared driving simulator performance, practical driving performance, and neuropsychological test results between patients with RHD who were able and unable to return to driving to predict driving fitness based on driving simulator performance. Methods This unmatched case-control study included 29 patients with RHD who were able (return-to-driving group, n = 16) and unable (non-return-to-driving group, n = 13) to return to driving. Patient demographics, motor function, attention, driving simulator performance (participants’ reaction time and rate to green lamps appearing in any of the three displays and average lane position), and practical driving performance were compared between the groups. Receiver operating characteristic (ROC) analysis was performed to examine the predictive performance of driving fitness in reaction rate and paper-and-pencil tests. Results The non-return-to-driving group had a significantly lower reaction rate than the return-to-driving group (p = 0.027; 95% confidence interval [CI], 0–7; r = 0.407). No significant difference in reaction time or lane position in either the left or right lane during driving simulation was observed. ROC analysis of the reaction rate in the driving simulator task showed sensitivity of 0.692, specificity of 0.812, and area under the curve of 0.738 [95% CI, 0.541–0.935]. Conclusions Decreases in reaction rates during simulated driving assessments are associated with an inability to resume driving in patients with RHD. Such assessments may aid in predicting fitness for driving in these patients.
Repurposing synthetic and natural derivatives induces apoptosis in an orthotopic glioma‐induced xenograft model by modulating WNT/β‐catenin signaling

Glioblastomas arise from multistep tumorigenesis of the glial cells. Despite the current state‐of‐art treatment, tumor recurrence is inevitable. Among the innovations blooming up against glioblastoma, drug repurposing could provide profound premises for treatment enhancement. While considering this strategy, the efficacy of the repurposed drugs as monotherapies were not up to par; hence, the focus has now shifted to investigate the multidrug combinations.
California sea lion (Zalophus californianus) lymph-node explant reveals involvement and possible transcriptional regulation of SLAM and nectin-4 during phocine distemper virus infection

Phocine distemper virus (PDV) is a significant cause of mortality for phocid seals; however, the susceptibility of otariids to this virus is poorly understood. The authors used a lymph-node explant culture system from California sea lions (Zalophus californianus, CSL) to investigate: (1) the role of signaling lymphocyte activation molecule (SLAM) and nectin-4 in PDV infection and their cellular expression patterns, (2) if PDV induces transcriptional regulation of cell-entry receptors, and (3) the involvement of apoptosis in PDV infection. PDV replicated in the lymph-node explants with peak replication 3 days post-infection (dpi), but the replication was not sustained 4 to 5 dpi. The PDV+ cells co-localized SLAM and nectin-4. These cells expressed IBA1, indicating a histiocytic lineage. Comparison of receptor expression between infected and mock-infected lymph nodes suggested transcriptional downregulation of both receptors during the initial stage of infection and upregulation during the late stage of infection, but the values lack of statistical significance. Cleaved caspase-3+ cells were slightly increased in the infected lymph nodes compared with the mock-infected lymph node from 1 to 4 dpi, but without statistical significance, and a few apoptotic cells co-expressed PDV. The results suggest that lymph-node explants might be an important model to study PDV pathogenesis. CSLs have the potential to be infected with PDV, as they express both cell-entry receptors in histiocytes. The lack of statistical significance in the PDV replication, transcriptional regulation of viral receptors, and changes in apoptosis suggest that although CSL might be infected by PDV, they might be less susceptible than phocid species.