Miracle-dz/UniFAR-FTUs huggingface dataset:
The Impact of Bariatric Surgery on Cardiovascular Risk Factors and Outcomes: A Systematic Review

Obesity and its complications are increasing in today's era, with cardiovascular health being one of the most significant obesity-related comorbidities. Hypertension in obesity is considered one of the major causes of death and disability due to their negative repercussions on cardiovascular health. Bariatric surgery is an approved therapeutic modality for obese people in classes II and III who have a body mass index (BMI) of more than 35 kg/m2 and 40 kg/m2, respectively. These weight loss surgeries are procedures that alter metabolism by causing weight reduction and altering gastrointestinal physiology, thereby considerably decreasing cardiometabolic risk factors that have been poorly understood to date. The purpose of this review is to explore the impact of bariatric surgery on reducing cardiac risk factors, in turn protecting the heart from succumbing to premature death. A literature search was done in the following databases: PubMed, Google Scholar, and PubMed Central (PMC). The studies taken into account for this review were observational studies published between 2016 and 2021 in the English language, where the quality was assessed using relevant quality appraisal methodologies. Finally, 10 reports were selected as definitive studies. Upon extensive evaluation of the final studies, it can be concluded that bariatric surgery results in significant weight loss, which lowers metabolic syndrome prevalence, cardiovascular risk factors, and major adverse cardiovascular events, particularly acute coronary events, and a favorable improvement in cardiac structure and function, altogether steering to reduced mortality due to cardiovascular diseases in obese patients. It is also worth noting that, while metabolic surgery can help patients with various metabolic comorbidities, the impact on individuals with hypertension is still debatable. Although the studies show significant effects on the cardiovascular system, these were only observational studies in geographically dispersed locations where each patient's lifestyle patterns and motivational levels could vary. Since real-world data are not fully explored due to the limited randomized controlled trials, it is suggested that further human trials on a larger scale be conducted to provide an even more factual conclusion.
Perceived discrimination and mental health of South American immigrants in Chile: the mediator role of the self-esteem in four nationalities

ABSTRACT Most international immigrants have mental health problems because of perceived discrimination. This research aims to analyze the possible mediating role of self-esteem in the impact of perceived discrimination on the mental health problems of the four most extensive South American immigrant nationalities in Chile. It involved 772 immigrants who have been living in this country for longer than a year. The results indicate that self-esteem would play a mediating role in two nationalities. We conclude by considering the importance and implications of self-esteem as a variable for intervention from social work in the immigration field.
Roles of autophagy in angiotensin II‐induced cardiomyocyte apoptosis

Autophagy is a self‐degradation process of cytoplasmic components and occurs in the failing heart. Angiotensin II plays a critical role in the progression of heart failure and induces autophagy. We investigated the mechanism underlying angiotensin II‐enhanced autophagy and examined the role of autophagy in angiotensin II‐induced cardiomyocyte injury. Neonatal rat cardiomyocytes were treated with angiotensin II (1–100 nmol/L). Angiotensin II dose‐dependently increased autophagy indicators of microtubule‐associated protein 1 light chain (LC) 3‐II and monodansylcadaverine‐labelled vesicles. It also enhanced the intracellular production of reactive oxygen species (ROS), assessed by H2DCFDA, an intracellular ROS indicator. NADPH oxidase‐ and mitochondria‐derived ROS production was increased by angiotensin II, while angiotensin II‐induced LC3‐II expression was suppressed by inhibitors of these sources of ROS. Confocal microscopy revealed that superoxide‐producing mitochondria colocalized with lysosomes after the angiotensin II stimulation. Myocyte apoptosis was assessed by nuclear staining with DAPI and caspase‐3 activity. A 6‐h stimulation with angiotensin II did not affect myocyte apoptosis, while a co‐treatment with 3‐methyl‐adenine (3MA), an autophagy inhibitor, augmented apoptosis. These results indicate that autophagy suppressed apoptosis because it removed damaged mitochondria in the early stages of the angiotensin II stimulation. A longer angiotensin II stimulation for 24 h induced apoptosis and propidium iodide‐positive lethal myocytes, while the co‐treatment with 3MA did not lead to further increases. In conclusion, angiotensin II‐induced autophagy removes ROS‐producing mitochondria. Autophagy is a beneficial phenomenon against myocyte apoptosis in the early phase, but its benefit was limited in the late phase of angiotensin II stimulation.
Investigating the role of the disclosure type in predicting the profitability of companies listed in the Tehran Stock Exchange

In economics, inflation is a sustained increase in the general price level of goods and services in an economy over a period of time. When the price level rises, each unit of currency buys fewer goods and services; consequently, inflation reflects a reduction in the purchasing power per unit of money – a loss of real value in the medium of exchange and unit of account within the economy. A chief measure of price inflation is the inflation rate, the annualized percentage change in a general price index, usually the consumer price index, over time. The opposite of inflation is deflation. If economic growth matches the growth of the money supply, inflation should not occur when all else is equal. A large variety of factors can affect the rate of both. For example, investment in market production, infrastructure, education, and preventative health care can all grow an economy in greater amounts than the investment spending.Methodology:the current study is descriptive correlational research. Based on nature of data, it is considered among the qualitative studies. The study period is from 2009 to 2013. The population of study included all 487 companies listed in Tehran Stock Exchange.Results:According to the findings of regression test, it can be stated that indices of levels of disclosure type, total level disclosure (TINDEX) and voluntary disclosure considering the P-value smaller than 0.05 are significantly effective in determining the profit quality level of studies companies.Conclusion:it could be concluded that in the case of the companies studied in this study, appropriate disclosure information of would lead to the positive consequences such as reducing the asymmetry of information, reducing the uncertainty about the future performance of the company, reducing the cost of stock transactions, increasing liquidity, and enhancing the efficiency of the capital market.
Pembelajaran Berbasis Kecerdasan Majemuk dalam Pendidikan Anak Usia Dini

Kecerdasan tidaklah dapat diukur hanya berdasarkan pada tes kecerdasan akademik atau IQ saja, melainkan dengan melihat kemampuan seseorang dalam menyelesaikan setiap permasalahan (problem solving) dan kemampuan dalam menciptakan produk baru yang memiliki nilai budaya (creativity). Tujuan penelitian ini adalah memberikan pengetahuan pembelajaran berbasis kecerdasan majemuk dalam Pendidikan anak usia dini, dan penerapan pembelajaran berbasis kecerdasan majemuk anak usia dini. Dengan kecerdasan tersebut peserta didik dapat menyesuaikan diri dan belajar dari pengalaman. Menurut Gardner, model pembelajaran ini adalah model pembelajaran yang menggunakan dan menerapkan teori inteligensi ganda yang perlu dipersiapkan dan dirancang dengan baik sebelum proses pembelajaran dilaksanakan Penelitian ini menggunakan metode kualitatif jenis deskriptif. Hasil dari penelitian ini menunjukkan bahwa pembelajaran berbasis kecerdasan majemuk dalam PAUD menuntut pendidik harus memiliki kreativitas yang cukup baik dengan menggunakan berbagai metode yang bervariasi dan menunjukkan bahwa penerapan pembelajaran berbasis kecerdasan majemuk dalam PAUD untuk meningkatkan keaktifan serta kreatifitas pendidik dan anak didik.
Late Pleistocene Mediterranean lynx remains from Avenc del Marge del Moro (NE Iberian Peninsula)

ABSTRACT During 2011, an international team of scientists successfully obtained for the first-time paleoDNA data from different samples of Lynx remains from the Iberian Peninsula. These results showed that these remains belonged to the species Lynx pardinus, which is, at present, one of the most critically endangered felids. One of the remains sampled in the aforementioned study comes from a small chasm called Avenc del Marge del Moro in the Garraf Massif, with an estimated absolute chronology of 21 ka. Further morphological studies reinforced the last evidence, corroborating the presence of Lynx pardinus from the Early to Late Pleistocene in Southern Europe. Here, we provide for the first time a detailed description of the lynx remains from Avenc del Marge del Moro, which consist of a remarkably complete fossil cranium, as well as several dentognathic and postcranial remains. In the light of the evidence reported the last 10 years for fossil L. pardinus and its past distribution throughout southern France and the Iberian and Italian Peninsulas, we further suggest a formal change of the vernacular name of this species to ‘Mediterranean lynx’. This also provides novel insight for future reintroduction opportunities of this species alongside the north Mediterranean coast in order to enhance its survival possibilities in wild ecosystems.
Investigating the effect of the Board of Directors characteristics on auditor selection in the companies listed in Tehran Stock Exchange

Objective: Purpose of the present research is to scrutinize the relationship between organizational agility and the application of information and communication technology. The present research is an applied descriptive and survey research of correlational type. Methodology: The statistical universe of this research involves the whole staff of the education organization of Shirvan Township in the year 2015 who are one hundred individuals and due to the diminutiveness of the statistical universe the complete enumeration. method has been used. To collect data the questionnaire of organizational agility of Sharifi & Zhang (1999) and the Information Technology survey Questionnaire of Rahmani (2010) were used. Validity of the questionnaire was calculated by 0.8365 by means of Cronbach’s Alpha coefficient for the Questionnaire of Information and Communication Technology and the validity of the Organizational Agility Questionnaire by 0.8076 which are indicative of the high validity of the questionnaire. Result: To analyze the collected data descriptive statistical methods (frequency distribution, percentage and mean) and inferential statistics (Pearson correlation coefficient) besides making use of SPSS software package, 19th version. Conclusion: Results indicate that there is a meaningful relationship between the application of information and communication technology and the organizational agility with a correlation coefficient of 0.746 and its level of significance equals zero which is less than 0.01. Thus, the existence of a meaningful relationship between the information and communication technology and the organizational agility with %99 certainty has been approved.
Explore the Role of the rs1801133-PPARG Pathway in the H-type Hypertension

Both rs1801133 mutation on Methylenetetrahydrofolate reductase (MTHFR) gene and transcription factor peroxisome proliferator-activated gamma (PPARG) have been associated with plasma homocysteine (Hcy) levels and hypertension. However, their role in H-type hypertension remains unclear. In this study, we first tested the association between rs1801133 genotypes and Hcy level in H-type hypertension using clinical profiles collected from 203 patients before and after the treatment using enalapril maleate and folic acid tablets (EMFAT). Then, we constructed a literature-based pathway analysis to explore the role of the rs1801133-PPARG signaling pathway in H-type hypertension and its treatment. Although presented similar blood pressure, the patients with TT genotype of rs1801133 were much younger (p value <0.05) and significantly higher in Hcy levels (x2 = 6.11 and p < 0.005) than that in the CC and CT genotype groups. Pathway analysis showed that T-allele of rs1801133 could inhibit the expression of PPARG through the downregulation of folate levels and upregulation of Hcy levels, which increased the risk of hypertension and hyperhomocysteinemia. Treatment using EMFAT led to similarly decreased Hcy levels for all patients with different genotypes (x2 = 86.00; p < 0.36), which may occur partially through the activation of PPARG. Moreover, even after treatment, the patients with TT genotype still presented significantly higher Hcy levels (x2 = 7.87 and p < 0.001). Our results supported that rs1801133 mutation could play a role in H-type hypertension, which might be partially through the downregulation of PPARG. Moreover, PPARG might also be involved in treating H-type hypertension using EMFAT.
An Extensive Comparison of the Clinical Efficiency of Acidulated Phosphate Fluoride (APF) and Neutral Sodium Fluoride (NaF) Oral Rinses in the Prevention of White Spot Lesions during Fixed Orthodontic Treatment: A Randomized Controlled Trial

Background The purpose of this randomized trial is to compare the efficacy of weekly once regime of neutral sodium fluoride (NaF) oral rinse with that of acidulated phosphate (APF) formulated daily mouth rinse in the reduction of white spot lesions (WSLs) associated with fixed orthodontic appliance treatment. Methods The participants (n = 90) of this single-center, two-arm parallel study without a control group were randomly assigned with 1 : 1 distribution to each of the two groups after the bonding of brackets. Group A/test group 1 (n = 45) was given weekly rinse of neutral sodium fluoride (Colgate® PreviDent® Dental Rinse-0.2% NaF), and for group B/test group 2 (n = 45), an APF formulated daily oral rinse (Colgate® Ortho Defense@ PhosFlur® Rinse-0.044% w/v of NaF) was given for six months. The outcome was assessed by the International Caries Detection and Assessment System (ICDAS) index for scoring the demineralization, and for scoring gingivitis, Loe and Silness gingival index (GI) was utilized. Four different time points “T0”immediately before bonding procedures, “T1” after 4weeks, “T2” after 12 weeks, and “T3” after 24 weeks were taken to assess the ICDAS and GI scores. Results The mean ICDAS scores for group A (NaF) were 0.025, 0.051, 0.093, and 0.113 and for group B (APF) were 0.014, 0.022, 0.038, and 0.015 at different points of time. The GI scores for group A were 0.008, 0.22, 0.33, and 0.38 and for group B were 0.003, 0.136, 0.181, and 0.097 at different time points. There was a statistically significant difference (p < 0.05) for both groups in terms of reducing WSL and GI. Conclusion APF formulated daily oral rinse—0.044% w/v of NaF—is more effective than the weekly once regimen of 0.2% NaF oral rinse to prevent white spot lesions.
Lockdown design: which features of lockdowns are most important to COVID-19 experts?

ABSTRACT Countries around the world, including New Zealand, have used lockdowns to slow the transmission of COVID-19. Reducing transmission depends crucially on people’s compliance with lockdowns, which depends on, among other things, their design. We report on a Discrete Choice Experiment (DCE) completed by 16 COVID-19 experts to discover how they feel about the relative importance (weight) of possible lockdown features in terms of how the features are experienced, independently of their effectiveness at controlling the pandemic. DCEs are widely used to understand people’s preferences with respect to the relative importance of the features of, in the present context, lockdowns. The lockdown features, in decreasing order of importance as determined by the DCE in terms of their inconvenience or unpleasantness, are (mean weights in parentheses): ‘travel restrictions’ (24.6%), ‘total cost of a vaccination (out-of-pocket or from taxes)’ (22.1%), ‘school closures’ (19.4%), ‘work from home’ (17.9%), ‘required to stay at home’ (9.6%) and ‘required to wear masks in public’ (6.5%). These results could be used by policy-makers to design lockdowns that are both effective in public health terms and most likely to be complied with. A larger-scale study involving the general population could be conducted in the future.
Should they change their answers or not? Modelling Achievement through a Metacognitive Lens

ABSTRACT Α frequently used indicator to reflect student performance is that of a test score. However, although tests are designed to assess students’ knowledge or skills, other factors can also affect test results such as test-taking strategies. Therefore, the purpose of this study was to model the interrelationships among test-taking strategy instruction (with a focus on metacognition), answer changing bias and performance on multiple-choice tests among college students through structural equation modelling. This study, which was based on a sample of 1512 students from Greece, has managed to extend the findings of previous research by proposing a model that demonstrates the interplay between these variables.
Economic valuation of Heyran telecabin recreational services

Poppulation growth and urbanization in recent years caused demand increase to utility of recreational services. Heyran telecabin recreational site is one of the most important place at the region and country due to tourism specification. So the study of Heyran telecabin recreational value can be significant to solve effect of this recreational places and tourism development. The aim of this research is the economic valuation of the Heyran telecabin recreational services. Logit model estimates on the maximum likelihood method to study in the effective factors on the people interest over the payment. Demanded data has been collected through questioner of 384 people of visitors from the corresponding forest by use of random sampling method. The results shows that 83.9 percent of visitors are interested on the payment in order to current forest. Also aducation variables,family size, sexuality, occupation, recommended price and income, have significant effect on the people willingness to pay but age variable, the importance of nature and marriage statue statically is not significant but it contains expected sign. The average of willingness to pay that it estimated about 32546 Rials for each visit.
Oil Price Change and Economic Growth: Evidence from Net Sub-Saharan Africa Oil Exporting Countries

This paper aimed at examining the long run relationship between the oil price change and economic growth for Sub-Saharan Africa (SSA) net oil exporters (Angola, Cameroon, Congo (Democratic Republic), Congo (The Republic), Equatorial Guinea, Gabon and Nigeria) with the sole purpose of pinpointing the threshold level where an increase beyond that is no longer or even contributing negatively to the economic growth of these countries. Based on the dynamic heterogenous panel PMG estimation, the empirical results show that a threshold level exists between oil price increase and economic growth for these countries, where an increase in oil price (op2) depicts a negative sign which is non-linear and at the same time signifying an inverted u shape relationship with the real GDP (rgdpc) as an indicator of economic growth. As the finding suggested, the rising oil price above certain threshold triggers fall in real GDP. However, the economies of these countries depend largely on oil revenue, therefore, economic diversification, saving and investing the excess of crude oil revenue at the time of higher oil prices became necessary to them in order to prevent their economies against the vagaries of volatility and uncertainty of the oil price.
Comparative Analysis of Efficacy and Prognosis of Hemodialysis and Peritoneal Dialysis for End-Stage Renal Disease: A Meta-analysis

Objective This meta-analysis is aimed at systematically assessing the efficacy and prognosis of hemodialysis (HD) and peritoneal dialysis (PD) in the treatment of end-stage renal disease (ESRD). Methods China National Knowledge Infrastructure, VIP, SinoMed, Cochrane Library, PubMed, and Embase databases were searched for relevant studies to evaluate the two different dialysis methods for ESRD. The search time was set from 2010 to 2021. Meta-analysis was performed using Stata16.0. The treatment group received PD, while the control group was given HD. Results Out of 317 articles initially retrieved, 14 studies were finally included in our meta-analysis. The analysis results showed that there was no marked difference in the 1-year survival rate between the two groups (RR = 1.05; 95% CI: 1.00, 1.10; P > 0.05), but the incidence rate of adverse reactions in the treatment group was significantly lower than that in the control group (RR = 0.51; 95% CI: 0.37, 0.70; P < 0.05). In addition, PD and HD treatments caused significant decreases in serum creatinine levels (PD, SMD = −2.91; 95% CI: -3.79, -2.04; P < 0.05; HD, SMD = −3.09; 95% CI: -4.01, -2.16; P < 0.05) and blood urea nitrogen levels (PD, SMD = −2.54, 95% CI: -3.37, -1.72, P < 0.05; HD, SMD = −2.62, 95% CI: -3.47, -1.77, P < 0.05); however, there was no significant statistical difference in posttreatment levels of serum creatinine and blood urea nitrogen between the two groups. Compared with the control group, the hemoglobin (SMD = 0.56, 95% CI: 0.07, 1.06; P < 0.05) and serum albumin (SMD = 1.11, 95% CI: 0.46, 1.76, P < 0.05) levels were significantly increased in the treatment group after treatment. Conclusion In summary, both PD and HD can improve renal function in uremic patients, but PD is superior to HD in reducing the incidence of adverse reactions, improving the nutritional status, and therefore improving the quality of life of patients.
Expression and Prognosis Value of the KLF Family Members in Colorectal Cancer

Krüppel-like factors (KLFs) are some kind of transcriptional regulator that regulates a broad range of cellular functions and has been linked to the development of certain malignancies. KLF expression patterns and prognostic values in colorectal cancer (CRC) have, however, been investigated rarely. To investigate the differential expression, predictive value, and gene mutations of KLFs in CRC patients, we used various online analytic tools, including ONCOMINE, TCGA, cBioPortal, and the TIMER database. KLF2-6, KLF8-10, KLF12-15, and KLF17 mRNA expression levels were dramatically downregulated in CRC tissues, but KLF1, KLF7, and KLF16 mRNA expression levels were significantly elevated in CRC tissues. According to the findings of Cox regression analysis, upregulation of KLF3, KLF5, and KLF6 and downregulation of KLF15 were linked with a better prognosis in CRC. For functional enrichment, our findings revealed that KLF members are involved in a variety of cancer-related biological processes. In colon cancer and rectal cancer, KLFs were also shown to be associated with a variety of immune cells. The findings of this research reveal that KLF family members' mRNA expression levels are possible prognostic indicators for patients with CRC.