Miracle-dz/UniFAR-FTUs huggingface dataset:
Cognitive Reappraisal Experimental Task: Replica in Mexican University Student

Background and Depression and anxiety, the most common mental disorders, have had a recent increase in prevalence in university students. The use of emotion regulation strategies and regulation success, which is predictive of mental health, have been primarily assessed through self-report, especially in Latin American samples. The present study sought to test a computerized emotion regulation experimental task in Mexican students samples. Method: Two Mexican samples of undergraduate and graduate students (Sample I: n = 49 and Sample II: n = 40) completed an experimental task (in-house Mexican Spanish translation). Participants were asked to decrease negative affect (reappraise) or react naturally in response to negative or neutral images and to self-report affect immediately after. Results: We found a significant decrease in negative affect when adopting a reappraisal strategy (decrease instruction) in the experimental task when participants were given verbal training instructions. However, these differences were not as strong when they were given in written form. Conclusions: Given that most disorders begin in the early decades of life and the current high prevalence of depression and anxiety in university students, as well the importance of emotion regulation in the onset or prevention of psychopathology, it is important to study these strategies worldwide. The current study presents evidence of reduced negative affect after using reappraisal during an experimental task in Mexican university students. Further, our results highlight the importance of matching processes and replicating results in different cultural contexts.
SENSIBILIDADE DO CLOROFILÔMETRO P ARA DIAGNÓSTICO NUTRICIONAL DE NITROGÊNIO NO MILHO Sensitivity of the chlorophyll meter for nutritional diagnostic of nitrogen in corn (Zea mays L.)

High corn yields are conditioned by the different factors involved in the quantification of nitrogen requirements for the crop throughout its cycle, which becomes difficult considering the varying capacity of Brazilian soils to supply N. In this sense, the relative contents of chlorophyll are a tool which helps to improve soil N management. The study aimed to evaluate the sensitivity of the chlorophyll meter to predict the nutrient status of corn in response to N applied in the soil with contracting clay contents and under different conditions of N supply. To that end, experiments were carried out under both controlled and field conditions. Under controlled conditions, three soils with contracting clay contents and five doses of N were tested. 55 days after emergence (before the VT period), the relative contents of chlorophyll, leaf N and the weight of the dry matter of the shoot were evaluated. Under crop conditions, six treatments, resulting from the combination of three doses of nitrogen topdressing, in the presence and absence of limestone, were evaluated, the highest dose of N corresponding to the ideal condition of N supply for corn. Nitrogen nutrition was monitored weekly with a chlorophyll meter. The contents of N in leaf, in grain, mineral N in soil, shoot dry matter and grain yield were also evaluated. The results allow concluding that there is a sensitivity of the chlorophyll meter to detect differences in the nutritional status of corn in response to different characteristics of soil and N supply, acting as an indicator of the need for nitrogen topdressing.
Repression of the Antioxidant Pyrroloquinoline Quinone in Skin Aging Induced by Bmi-1 Deficiency

It is uncertain whether Bmi-1 deficiency could lead to skin aging by redox imbalance and DNA damage. In this study, we first confirmed that Bmi-1 had a relatively high expression level in the skin and Bmi-1 expression levels gradually decreased with age. Then, we studied the role of Bmi-1 in the skin using a Bmi-1−/− mouse model. Bmi-1−/− mice were supplemented with or without pyrroloquinoline quinone (PQQ) for 5 weeks, and their skin phenotypes were compared with Bmi1−/− and wild-type littermates. Our results showed that Bmi-1−/− mice displayed decreased vertical thickness of skin, sparse hair follicles, and thinner and more irregular collagen bundles. Mechanistically, increased oxidative stress with reducing antioxidant capacity and induced DNA damage occurred in Bmi-1−/− mice. Subsequently, this would lead to reduced cell proliferation, increased cell senescence and matrix metalloproteinases (MMPs), and the degradation of fibroblast function and further reduce collagen synthesis. All pathological alterations in the skin of Bmi-1−/− mice were alleviated by PQQ supplementation. These results demonstrated that Bmi-1 might play a key role in protection from skin aging by maintaining redox balance and inhibiting DNA damage response and will be a novel and potential target for preventing skin aging.
Green banana biomass (Musa sp.) as an ingredient in the development of pasta

Green banana biomass (GBB) can be used as a functional and technological ingredient in various food preparations, making them healthier and more nutritious. The aim of the present study was to determine the physicochemical compositions as well as color parameters of different GBB samples, and applying them to gnocchi pasta to determine the resulting technological and cooking properties. The bananas (‘BRS Platina, ‘Fhia 01,’ and ‘Fhia 18’) were grown in an area of the Agroecological Production Integrated System, in Seropédica-RJ, Brazil; the bananas were harvested unripe and pressured cooked to obtain their biomass. The pH values, total titratable acidity, total soluble solids, reducing sugars, moisture, ash, proteins, lipids, total starch, total energetic value (TEV), vitamin C, total phenolic compounds (TPC), minerals, and color were significantly different among the different GBB samples used. Each GBB showed different values of certain analyzed parameters; for instance, ‘BRS Platina’ presented low contents of total starch, lipids, TEV and high levels of vitamin C and TPC. The GBB ‘Fhia 01’presented the highest levels of moisture, proteins, and potassium. All GBBs provided good technological attributes (cooking time, weight increase, cooking loss, and volume increase) for the prepared gnocchi dough. Overall, the application of GBB as an ingredient in gnocchi formulation provided good technological quality and increased nutritional value, thus meeting the growing demand of the consumer market for products with greater health benefits.
Firm Life Cycle Stage and Dividend Payout of Listed Non-Financial Firms in Selected Sub-Saharan African Countries: A Sectoral Analysis

This study explored the sector-wise effect of firm life cycle stage on dividend payout of listed non-financial firms in three selected Sub-Saharan African countries that include; South Africa, Nigeria, and Kenya. The study utilized longitudinal and causal research designs. Four hundred and seventy-nine (479) non-financial companies in eleven (11) sub-sectors listed on Nigerian, Johannesburg, and Nairobi Stock Exchanges make up the population. However, the Utility sector was removed from the final analysis because the sample size for this subsector was not enough to carry out the system GMM analysis. Thus, analysis was done for ten (10) subsectors. Two hundred and thirty-nine (239) quoted non-financial firms in ten (10) sub-sectors were chosen and data were collected for the period 2007 to 2017. The dynamic panel data regression technique (system generalized method of moments) was used for the data analysis. The outcomes of the empirical analysis revealed that the earned/contributed capital mix exerts a direct and significant effect on the payout of dividend in seven out of the 10 subsectors analyzed while firm age exerts an inverse and significant effect on the payout of dividend in six out of the 10 subsectors analyzed. The study concludes that the firm life cycle stage influences payout of the dividend of listed non-financial companies in the selected Sub-Saharan Africa countries. The study recommended among others that stock market regulators in the selected Sub-Sahara Africa countries should consider the life cycle stage of the firms and the earned/contributed capital mix should be used in measuring the maturity of firms, thus the payment of dividend by firms should be based on when its profitability and growth rate are expected to fall in future.
Assessment of Reinforced Concrete Highway Bridges

The primary contributor to the corrosion of bridges in Canada is heavy use of de-icing salts, which can lead to severe rebar corrosion and girder soffit spalling in reinforced concrete (RC) highway bridges. This paper discusses recent challenges faced by authorities in dealing with corrosion problems in Canadian highway bridges, and describes typical approaches for the assessment and management of these structures. The study developed a methodology for evaluating the residual strength of spalled RC bridges. The basis for this methodology is a modified area concept, which can be used to consider the effects of exposed reinforcement at various locations along the girder length. The study developed a multipoint analysis program, which employs the modified area concept, along with graphical spalling surveys and structural drawings, to evaluate RC bridge girders. The program was adapted for a full bridge analysis and to consider other effects of corrosion, such as bar section loss and bond deterioration. A case study bridge was evaluated to show that the developed program offers a viable tool for the rapid assessment of spalled bridge girders, to facilitate the prioritization of rehabilitation projects. The methodology was evaluated in a pilot laboratory study, wherein soffit spalling simulated on reduced-scale concrete beam specimens and safe and accurate predictions of the specimen capacity were obtained using the modified area concept.
Assessment of Physiological Rat Kidney Ageing—Implications for the Evaluation of Allograft Quality Prior to Renal Transplantation

Due to organ shortage and rising life expectancy the age of organ donors and recipients is increasing. Reliable biomarkers of organ quality that predict successful long-term transplantation outcomes are poorly defined. The aim of this study was the identification of age-related markers of kidney function that might accurately reflect donor organ quality. Histomorphometric, biochemical and molecular parameters were measured in young (3-month-old) and old (24-month-old) male Sprague Dawley rats. In addition to conventional methods, we used urine metabolomics by NMR spectroscopy and gene expression analysis by quantitative RT-PCR to identify markers of ageing relevant to allograft survival. Beside known markers of kidney ageing like albuminuria, changes in the concentration of urine metabolites such as trimethylamine-N-oxide, trigonelline, 2-oxoglutarate, citrate, hippurate, glutamine, acetoacetate, valine and 1-methyl-histidine were identified in association with ageing. In addition, expression of several genes of the toll-like receptor (TLR) pathway, known for their implication in inflammaging, were upregulated in the kidneys of old rats. This study led to the identification of age-related markers of biological allograft age potentially relevant for allograft survival in the future. Among those, urine metabolites and markers of immunity and inflammation, which are highly relevant to immunosuppression in transplant recipients, are promising and deserve further investigation in humans.
Turbine Blade Platform Impingement Cooling With Effects of Film Extraction and Roughness

With the movement of combustion systems to flatter exit temperature profiles for the purpose of reduced emissions, vane endwalls and blade platforms are experiencing higher gas temperatures than previously. While vane endwalls may be cooled by conventional methods extended from the airfoil techniques, blade platforms require simple but robust cooling methods that are amenable to the high rotational loads. This study presents a platform cooling solution that utilizes a single impingement jet directed to the underside of the platform from the forward shank face. Detailed local distributions of heat transfer coefficients are presented for the cooled platform region formed by the cavity between the pressure side and suction side of two adjacent blade castings. Fundamental understanding is provided for impingement into this confined cavity region, with two differing jet positions. The effects of jet impingement distance to the surface from Z/D of 1.5 to 8, and jet Reynolds number from 65,000 to 155,000 are investigated. Furthermore, to augment the cooled surface heat transfer coefficients, surface roughness is applied by a patented method appropriate to actual turbine hardware. The single cooling jet produces a platform cooling distribution that may be treated as two distinct regions. The primary impingement region is seen to behave in line with expectations from prior literature, with some cavity geometry effects. Impingement heat transfer coefficients are increased by as much as 50% through the use of an applied randomly roughened surface that models an actual braze alloy method. This roughness benefit is however lost if the impingement cooling jet is not relatively close to the platform surface. The non-impingement heat transfer regions of the platform are affected only by the total cooling flow rate supplied by the impingement jet. © 2005 ASME
Lipoteichoic Acid from Lacticaseibacillus rhamnosus GG Modulates Dendritic Cells and T Cells in the Gut

Lipoteichoic acid (LTA) from Gram-positive bacteria exerts different immune effects depending on the bacterial source from which it is isolated. Lacticaseibacillus rhamnosus GG LTA (LGG-LTA) oral administration reduces UVB-induced immunosuppression and skin tumor development in mice. In the present work, we evaluate the immunomodulatory effect exerted by LGG-LTA in dendritic cells (DC) and T cells, both in vitro and in the gut-associated lymphoid tissue (GALT). During cell culture, LTA-stimulated BMDC increased CD86 and MHC-II expression and secreted low levels of pro and anti-inflammatory cytokines. Moreover, LTA-treated BMDC increased T cell priming capacity, promoting the secretion of IL-17A. On the other hand, in orally LTA-treated mice, a decrease in mature DC (lamina propria and Peyer’s patches) was observed. Concomitantly, an increase in IL-12p35 and IFN-γ transcription was presented (lamina propria and Peyer’s Patches). Finally, an increase in the number of CD103+ DC was observed in Peyer’s patches. Together, our data demonstrate that LGG-LTA activates DC and T cells. Moreover, we show that a Th1-biased immune response is triggered in vivo after oral LTA administration. These effects justify the oral LTA activity previously observed.
Self-Reported Pain and Emotional Reactivity in Bipolar Disorder: A Prospective FACE-BD Study

In patients with bipolar disorder (BD), pain prevalence is close to 30%. It is important to determine whether pain influences BD course and to identify factors associated with pain in BD in order to guide BD management. This naturalistic, prospective study used data on 880 patients with BD from the French FACE-BD cohort who were divided into two groups according to the presence or absence of pain. Multivariate models were used to test whether pain was associated with affective states and personality traits while controlling for confounders. Then, multivariate models were used to test whether pain at baseline predicted global life functioning and depressive symptomatology at one year. At baseline, 22% of patients self-reported pain. The pain was associated with depressive symptomatology, levels of emotional reactivity in a quadratic relationship, and a composite variable of personality traits (affective lability, affective intensity, hostility/anger, and impulsivity). At one year, the pain was predictive of depression and lower global life functioning. Pain worsens mental health and well-being in patients with BD. The role of emotions, depression, and personality traits in pain has to be elucidated to better understand the high prevalence of pain in BD and to promote specific therapeutic strategies for patients experiencing pain.
Expression analysis of Huntington disease mouse models reveals robust striatum disease signatures

Huntington’s disease is caused by expanded trinucleotide repeats in the huntingtin gene (HTT), and a higher number of repeats is associated with an earlier age of disease onset. Although the causative gene has been identified, its connections to the observed disease phenotypes is still unclear. Mouse models engineered to contain increasing numbers of trinucleotide repeats were sacrificed at different ages to detect RNA-level and protein-level changes specific to each repeat length and age in order to examine the transcriptional and translational characteristics of the disease. RNA-seq and quantitative proteomics data were collected on 14 types of tissues at up to 8 repeat lengths and in up to 3 different ages, and differential gene and protein expression were examined. A modified method of imputing missing proteomics data was employed and is described here. The most dysregulated tissue at both the RNA and protein levels was the striatum, and a strong gender effect was observed in all of the liver experiments. The full differential expression results are available to the research community on the HDinHD.org website. The results of multiple expression tests in the striatum were combined to generate an RNA disease signature and a protein disease signature, and the signatures were validated in external data sets. These signatures represent molecular readouts of disease progression in HD mice, which further characterizes their HD-related phenotype and can be useful in the preclinical evaluation of candidate therapeutic interventions. Author Summary Mouse models of Huntington’s disease were engineered to allow a detailed examination of how the disease causes changes in gene activity in a variety of tissues. Among the 14 tissues studied, the one most affected by the disease in our experiments was the striatum, a brain region involved in voluntary movement. The liver results showed large differences in gene activity between the male and female mice. In our analysis, we propose a minor change in how proteomics data is typically analyzed in order to improve the ranking of significant results. Using the striatum data in this study and in others, we identified robust genetic signatures of disease at both the RNA and protein levels.
External validation of five predictive models for postoperative cardiopulmonary morbidity in a Chinese population receiving lung resection

Background No postoperative cardiopulmonary morbidity models have been developed or validated in Chinese patients with lung resection. This study aims to externally validate five predictive models, including Eurolung models, the Brunelli model and the Age-adjusted Charlson Comorbidity Index, in a Chinese population. Methods Patients with lung cancer who underwent anatomic lung resection between 2018/09/01 and 2019/08/31 in our center were involved. Model discrimination was assessed by the area under the receiver operating characteristic curve. Model calibration was evaluated by the Hosmer–Lemeshow test. Calibration curves were plotted. Specificity, sensitivity, negative predictive value, positive predictive value and accuracy were calculated. Model updating was achieved by re-estimating the intercept and/or the slope of the linear predictor and re-estimating all coefficients. Results Among 1085 patients, 91 patients had postoperative cardiopulmonary complications defined by the European Society of Thoracic Surgeons. For original models, only parsimonious Eurolung1 had acceptable discrimination (area under the receiver operating characteristic curve = 0.688, 95% confidence interval 0.630–0.745) and calibration (p = 0.23 > 0.05) abilities simultaneously. Its sensitivity, specificity, positive predictive value, negative predictive value and accuracy were 0.700, 0.649, 0.153, 0.960 and 0.653, respectively. In the secondary analysis, increased pleural effusion (n = 94), which was nonchylous and nonpurulent, was labeled as a kind of postoperative complication. The area under the receiver operating characteristic curve of the models increased slightly, but all models were miscalibrated. The original Eurolung1 model had the highest discrimination ability but poor calibration, and thus it was updated by three methods. After model updating, new models showed good calibration and small improvements in discrimination. The discrimination ability was still merely acceptable. Conclusions Overall, none of the models performed well on postoperative cardiopulmonary morbidity prediction in this Chinese population. The original parsimonious Eurolung1 and the updated Eurolung1 were the best-performing models on morbidity prediction, but their discrimination ability only achieved an acceptable level. A multicenter study with more relevant variables and sophisticated statistical methods is warranted to develop new models among Chinese patients in the future.
Revista de Comunicación de la SEECI

CARTA DE ORIGINALIDAD Con este documento, el autor/es, D. Cruz García Lirios, Francisco Rubñén Sandoval Vázquez, José Alfosno Aguilar Fuentes, solicita/n que su artículo titulado “APROXIMACIÓN AL ENCUADRE DE LOS MEDIOS IMPRESOS EN TORNO A LA ATENCIÓN A VÍCTIMAS DEL CASO AYOTZINAPA, IGUALA-GUERRERO (MÉXICO)”, sea sometido al método de revisión por pares ciegos para su posible publicación en la Revista de Comunicación de la SEECI (www.seeci.net/revista) con ISSN 1576-3420.
Minireview: Parabens Exposure and Breast Cancer

There is increasing recognition that environmental exposure to chemicals, such as endocrine-disruptive chemicals (EDCs), contributes to the development of breast cancer. Parabens are a group of EDCs commonly found in personal care products, foods, and pharmaceuticals. Systemic exposure to parabens has been confirmed by the ubiquitous detection of parabens in human blood and urine samples. Although evidence from in vivo and epidemiological studies linking parabens exposure to breast cancer is limited, the current evidence suggests that parabens may negatively interfere with some endocrine and intracrine targets relevant to breast carcinogenesis. So far, most studies have focused on a single paraben’s effects and the direct modulating effects on estrogen receptors or the androgen receptor in vitro. Recent studies have revealed that parabens can modulate local estrogen-converting enzymes, 17β-hydroxysteroid dehydrogenase 1 and 2 and increase local estrogen levels. Also, parabens can crosstalk with the human epidermal growth factor receptor 2 (HER2) pathway and work with ER signaling to increase pro-oncogenic c-Myc expression in ER+/HER2+ breast cancer cells. Future studies investigating paraben mixtures and their crosstalk with other EDCs or signaling pathways both in vitro and in vivo in the context of breast cancer development are warranted.
A Review of Community Radio Literature in Developing Countries from 2010 to 2020

ABSTRACT Globally, there has been a continuing increase in the number of community radio stations. With this comes the need to better understand the direction that community radio should take and its roles in confronting pressing global issues. Hence, this paper reviewed the literature on community radio in the past 10 years, i.e., from 2010–2020. The review covered 25 empirical studies conducted in developing countries. Leximancer was used to assist in data analysis. It was found that the literature has focused on how community radio is developing communities through information dissemination, community participation/inclusion, and community access through programming among others.