Miracle-dz/UniFAR-FTUs huggingface dataset:
Validation of Fitbit Charge 4 for assessing sleep in Chinese patients with chronic insomnia: A comparison against polysomnography and actigraphy

Our research aims to assess the performance of a new generation of consumer activity trackers (Fitbit Charge 4TM: FBC) to measure sleep variables and sleep stage classifications in patients with chronic insomnia, compared to polysomnography (PSG) and a widely used actigraph (Actiwatch Spectrum Pro: AWS). We recruited 37 participants, all diagnosed with chronic insomnia disorder, for one night of sleep monitoring in a sleep laboratory using PSG, AWS, and FBC. Epoch-by-epoch analysis along with Bland–Altman plots was used to evaluate FBC and AWS against PSG for sleep-wake detection and sleep variables: total sleep time (TST), sleep efficiency (SE), waking after sleep onset (WASO), and sleep onset latency (SOL). FBC sleep stage classification of light sleep (LS), deep sleep (DS), and rapid eye movement (REM) was also compared to that of PSG. When compared with PSG, FBC notably underestimated DS (-41.4, p < 0.0001) and SE (-4.9%, p = 0.0016), while remarkably overestimating LS (37.7, p = 0.0012). However, the TST, WASO, and SOL assessed by FBC presented no significant difference from that assessed by PSG. Compared with PSG, AWS and FBC showed great accuracy (86.9% vs. 86.5%) and sensitivity (detecting sleep; 92.6% vs. 89.9%), but comparatively poor specificity (detecting wake; 35.7% vs. 62.2%). Both devices showed better accuracy in assessing sleep than wakefulness, with the same sensitivity but statistically different specificity. FBC supplied equivalent parameters estimation as AWS in detecting sleep variables except for SE. This research shows that FBC cannot replace PSG thoroughly in the quantification of sleep variables and classification of sleep stages in Chinese patients with chronic insomnia; however, the user-friendly and low-cost wearables do show some comparable functions. Whether FBC can serve as a substitute for actigraphy and PSG in patients with chronic insomnia needs further investigation.
OXYGEN ABUNDANCES IN NEARBY FGK STARS AND THE GALACTIC CHEMICAL EVOLUTION OF THE LOCAL DISK AND HALO

Atmospheric parameters and oxygen abundances of 825 nearby FGK stars are derived using high-quality spectra and a non-local thermodynamic equilibrium analysis of the 777 nm O i triplet lines. We assign a kinematic probability for the stars to be thin-disk (P1), thick-disk (P2), and halo (P3) members. We confirm previous findings of enhanced [O/Fe] in thick-disk (P2 > 0.5) relative to thin-disk (P1 > 0.5) stars with [Fe/H] ≲ −0.2, as well as a “knee” that connects the mean [O/Fe]–[Fe/H] trend of thick-disk stars with that of thin-disk members at [Fe/H] ≳ −0.2. Nevertheless, we find that the kinematic membership criterion fails at separating perfectly the stars in the [O/Fe]–[Fe/H] plane, even when a very restrictive kinematic separation is employed. Stars with “intermediate” kinematics (P1 < 0.7, P2 < 0.7) do not all populate the region of the [O/Fe]–[Fe/H] plane intermediate between the mean thin-disk and thick-disk trends, but their distribution is not necessarily bimodal. Halo stars (P3 > 0.5) show a large star-to-star scatter in [O/Fe]–[Fe/H], but most of it is due to stars with Galactocentric rotational velocity V < −200 km s−1; halo stars with V > −200 km s−1 follow an [O/Fe]–[Fe/H] relation with almost no star-to-star scatter. Early mergers with satellite galaxies explain most of our observations, but the significant fraction of disk stars with “ambiguous” kinematics and abundances suggests that scattering by molecular clouds and radial migration have both played an important role in determining the kinematic and chemical properties of solar neighborhood stars.
Widespread expression of the ancient HERV-K (HML-2) provirus group in normal human tissues

Human endogenous retrovirus (HERV) transcripts are known to be highly expressed in cancers, yet their activity in nondiseased tissue is largely unknown. Using the GTEx RNA-seq dataset from normal tissue sampled at autopsy, we characterized individual expression of the recent HERV-K (HML-2) provirus group across 13,000 different samples of 54 different tissues from 948 individuals. HML-2 transcripts could be identified in every tissue sampled and were elevated in the cerebellum, pituitary, testis, and thyroid. A total of 37 different individual proviruses were expressed in 1 or more tissues, representing all 3 LTR5 subgroups. Nine proviruses were identified as having long terminal repeat (LTR)-driven transcription, 7 of which belonged to the most recent LTR5HS subgroup. Proviruses of different subgroups displayed a bias in tissue expression, which may be associated with differences in transcription factor binding sites in their LTRs. Provirus expression was greater in evolutionarily older proviruses with an earliest shared ancestor of gorilla or older. HML-2 expression was significantly affected by biological sex in 1 tissue, while age and timing of death (Hardy score) had little effect. Proviruses containing intact gag, pro, and env open reading frames (ORFs) were expressed in the dataset, with almost every tissue measured potentially expressing at least 1 intact ORF (gag).
Acceptance and hesitancy of parents to vaccinate children against coronavirus disease 2019 in Saudi Arabia

Background Vaccination of masses against coronavirus disease 2019 (COVID-19) is critical to overcome the pandemic and restore normalcy. However, vaccine refusal and hesitancy prevail in many countries. COVID-19 has rapidly spread in Saudi Arabia since 2020. The acceptance rate of COVID-19 vaccines has been investigated in adults aged >18 years in Saudi Arabia. This study aimed to understand the acceptance and hesitancy of parents to vaccinate children aged <12 years against COVID-19 in Saudi Arabia and identify strategies that can encourage their engagement. Methods We used an online cross-sectional survey distributed to parents who lived in all regions of Saudi Arabia to investigate parents’ views on the acceptability of a future COVID-19 vaccine for their children aged <12 years. Five hundred parents living in Saudi Arabia completed the survey. Results The survey indicated that mothers were more enthusiastic about participating in the study than fathers. The participant aged 37.31 ± 8.52 years. A total of 38.6% of participants refused to vaccinate their children. Additionally, 56% were unsure if the vaccine would cause serious side effects in children. A total of 48.8% of parents believed that the Pfizer vaccine was suitable for children, while 64.5% failed to decide whether to administer vaccines to their children. Conclusion Vaccine hesitancy remains a major problem worldwide. A lack of scientific evidence on vaccine efficacy, low education level, and reduced level of health education and promotion are the most common factors in parents in Saudi Arabia. However, some participants agreed to receive vaccines only to protect their family members, and due to governmental rules and school mandates. Therefore, vaccine efficacy and safety in children must be clearly communicated to the public. This information would aid in reducing the hesitancy of parents to vaccinate their children against COVID-19.
Arguments for the biological and predictive relevance of the proportional recovery rule

The proportional recovery rule (PRR) posits that most stroke survivors can expect to reduce a fixed proportion of their motor impairment. As a statistical model, the PRR explicitly relates change scores to baseline values – an approach that arises in many scientific domains but has the potential to introduce artifacts and flawed conclusions. We describe approaches that can assess associations between baseline and changes from baseline while avoiding artifacts due either to mathematical coupling or to regression to the mean. We also describe methods that can compare different biological models of recovery. Across several real datasets in stroke recovery, we find evidence for non-artifactual associations between baseline and change, and support for the PRR compared to alternative models. We also introduce a statistical perspective that can be used to assess future models. We conclude that the PRR remains a biologically relevant model of stroke recovery.
The relationship between past exercise behavior and future exercise adherence: A sequential mediation analysis

ABSTRACT The present study explored the mediation role of past exercise adherence, self-reported frequency and intentions in the association between past experience and future exercise adherence. In total, 431 exercisers (female = 216; male = 215) aged 18 and 64 years, engaged in fitness activities such as group fitness classes and resistance training, were included in the analysis. Serial mediation procedures were employed to examine the direct, indirect, and total indirect effects among variables. The predictor variable and all mediators displayed a positive and significant association with future six-month adherence. Past six-month exercise adherence displayed the most significant association with future six-month adherence. The sequential indirect path from exercise experience → past six-months adherence → self-reported frequency → intentions future six-months adherence displayed a positive and significant effect (β = .19 [CI95% = .09, .31]), presenting a partial mediation effect. Past behaviour is the most significant predictor of future adherence, and thus interventions should be based on promoting consistent exercise frequency. Professionals working in the fitness centre context can identify possible dropouts based on their past behaviour and intentions to be physically active in the future.
Propensity-matched Comparison Between Chronic Nonspecific Low Back Pain and Axial Spondyloarthritis: Impact on patient-perceived Quality of Life

Study Design. Prospective study. Objective. To compare the burden between chronic nonspecific low back pain (LBP) and axial spondyloarthropathy (SpA). Summary of Background Data. Chronic nonspecific LBP and SpA are two debilitating yet different chronic musculoskeletal disorders. To compare their burden, propensity score matching is used to control for potential confounders and match the study subjects. Materials and Methods. Two prospectively collected cohorts of LBP (n=269) and SpA (n=218) patients were studied. Outcomes included current LBP, 36-item Short Form Questionnaire, Oswestry Disability Index, EuroQol 5-dimension 5-level Questionnaire, and EuroQol Visual Analog Scale. With the inherent differences between the two types of patients, propensity score matching was performed for comparing the two groups. Baseline covariates of age, sex, education level, occupation, smoking, and drinking history were selected for the estimation of propensity scores for each subject with the logistic regression model. Significant independent variables for the outcome of current back pain were included in the multivariate logistic regressions. Results. A total of 127 matched pairs were identified, with 254 patients. In the matched cohort, more patients with chronic LBP had current back pain (95.3%) as compared with SpA (71.7%). Patients with SpA were younger (P<0.001), with more males (P<0.001), and better educated (P=0.001). There was less current back pain and higher nonsteroidal anti-inflammatory drug use (P<0.001). Most SpA patients had lower Oswestry Disability Index than LBP patients and with low disease activity. Patients with LBP had worse outcome scores as compared with SpA patients given the same Visual Analog Scale. LBP patients had 8.6 times the odds (95% CI: 3.341–20.671; P<0.001) of experiencing current back pain compared with SpA patients. Conclusions. The disease activity of SpA patients is well controlled. However, patients with chronic LBP have worse pain severity, disability, and health-related quality of life. This has implications on resource utilization and the necessity of advancing LBP understanding and management. Level of Evidence. Type I prognostic study.
The effect of oral refeeding compared with nasogastric refeeding on the quality of care for patients hospitalised with an eating disorder: A systematic review

Abstract Aim The aim of this systematic review was to compare the benefits and harms of nasogastric and oral‐based refeeding on the quality of care, including effectiveness, safety, and patient experience, for patients hospitalised with an eating disorder. Methods A systematic search for studies measuring comparative data between nasogastric and oral refeeding methods was conducted in August 2021. Title and abstracts and remaining full texts were screened by both authors. Risk of bias was evaluated using the PEDro scale, and overall quality of evidence was assessed using the Grading of Recommendations, Assessment, Development and Evaluation narrative synthesis. Results Seven studies (one randomised controlled trial, five non‐randomised studies of interventions, and one qualitative study) with 917 participants were included. There was low certainty evidence that nasogastric refeeding resulted in no difference or a small increase in weekly weight gain, and moderate certainty of greater total weight gain, and very low certainty of increased length of stay compared to oral refeeding. There was no difference or a small increase in discharge weight and body mass index with nasogastric refeeding compared to oral refeeding. No serious adverse events were reported. Conclusion Patients selected for nasogastric refeeding have a longer duration of illness and lower admission weight, making it difficult to determine which refeeding approach is superior. However, the lack of clear difference in weekly weight gain and the lack of reported harms suggests that other factors such as the normalisation of eating behaviour may be taken into account when choosing the most appropriate refeeding method.
Effectiveness of a low-cost UVGI chamber for decontaminating filtering facepiece respirators to extend reuse

Abstract In emergencies like the COVID-19 pandemic, the reuse or reprocessing of filtering facepiece respirators (FFRs) may be required to mitigate exposure risk. Research gap: Only a few studies evaluated decontamination effectiveness against SARS-CoV-2 that are practical for low-resource settings. This study aimed to determine the effectiveness of a relatively inexpensive ultraviolet germicidal irradiation chamber to decontaminate FFRs contaminated with SARS-CoV-2. A custom-designed UVGI chamber was constructed to determine the ability to decontaminate seven FFR models including N95s, KN95, and FFP2s inoculated with SARS-CoV-2. Vflex was excluded due to design folds/pleats and UVGI shadowing inside the chamber. Structural and functional integrity tolerated by each FFR model on repeated decontamination cycles was assessed. Twenty-seven participants were fit-tested over 30 cycles for each model and passed if the fit factor was ≥100. Of the FFR models included for testing, only the KN95 model failed filtration. The 3M™ 3M 1860 and Halyard™ duckbill 46727 (formerly Kimberly Clark) models performed better on fit testing than other models for both pre-and-post decontaminations. Fewer participants (0.3 and 0.7%, respectively) passed fit testing for Makrite 9500 N95 and Greenline 5200 FFP2 and only two for the KN95 model post decontamination. Fit testing appeared to be more affected by donning & doffing, as some passed with adjustment and repeat fit testing. A ≥ 3 log reduction of SARS-CoV-2 was achieved for worn-in FFRs namely Greenline 5200 FFP2. Conclusion: The study showed that not all FFRs tested could withstand 30 cycles of UVGI decontamination without diminishing filtration efficiency or facial fit. In addition, SARS-CoV-2 log reduction varied across the FFRs, implying that the decontamination efficacy largely depends on the decontamination protocol and selection of FFRs. We demonstrated the effectiveness of a low-cost and scalable decontamination method for SARS-CoV-2 and the effect on fit testing using people instead of manikins. It is recognized that extensive experimental evidence for the reuse of decontaminated FFRs is lacking, and thus this study would be relevant and of interest in crisis-capacity settings, particularly in low-resource facilities.
Themes of Trust, Identity, Intimacy, and Generativity in Important Autobiographical Memories: Associations with Life Periods and Life Satisfaction.

INTRODUCTION Guided by Erikson's theory of psychosocial development, the present study investigated whether themes of trust, identity, intimacy, and generativity are represented in older adults' most important autobiographical memories. Furthermore, we tested whether these themes are associated with certain life periods and whether having important memories (i.e., life story) that reflect developmental themes and are evaluated as positive is associated with life satisfaction. METHODS 112 (59.8 % female) older adults (61-92 years, M=70.96, SD=6.81) reported up to 15 important autobiographical memories. Participants rated each memory according to the themes of trust/ mistrust, identity/ confusion, intimacy/ isolation, and generativity/ stagnation. RESULTS Using multilevel multinomial logistic regression, we found childhood memories to be associated with trust, memories from participants' youth with identity and intimacy, and adulthood memories with intimacy and generativity. Moreover, participants who rated their autobiographical memories (i.e., life story) as high in reflecting themes and, at the same time, perceived their memories as more positive showed higher levels of life satisfaction. CONCLUSION Important autobiographical memories reflect how an individual became the person of today. They refer to age-related themes of psychosocial development and are associated with a person's life satisfaction if they are also considered as emotionally more positive.
Long‐term occurrence probabilities of intense geomagnetic storm events

A quantitative assessment of the occurrence probability of intense geomagnetic storms (peak Dst < −100 nT) has been investigated by analyzing the Dst index time series database from 1957 to 2001. The main purpose was to derive two parameters, the probable intensity ST and the occurrence frequency λt, that can act as proxies for long‐term space weather quantities. The intensity ST represents the expected maximum storm level with an occurrence rate of 1/T (a−1, where a is years) and has been derived from the probability density function (PDF) of extreme (∣Dst∣ > 280 nT) storms. The mathematical tool to determine this type of PDF is the extreme value modeling, which exhibits more accurate statistics for extreme behavior. Our results estimate S60 ≈ 589, indicating that the March 1989 storm (the event with the largest ∣Dst∣ in the database) corresponds to an event expected to occur only once every 60 a. The other parameter λt gives the average occurrence rate of storm events. We have tested the null hypothesis that the storm occurrence pattern can be modeled as a Poisson process represented by λt, where different λt exist for the active and quiet periods of the solar cycle. Ordinary χ2 tests of goodness of fit can not reject this hypothesis, except within the periods that include extremely frequent occurrences. The rate λt is approximately 2.3 (0.7) per 3 months in the active (quiet) period. A future practical application of this work is that the resultant Poisson probability will enable us to calculate the expected damage due to storms, which represent potential risks in space activities.
Notable impact of wildfires in the western United States on weather hazards in the central United States

Significance Wildfires have intensified in both frequency and burned areas in recent decades in the United States and constitute a significant threat to life and property. Sensible heat and aerosols produced by wildfires may affect severe storms and weather hazards downstream. Here, we show that wildfires in the western United States can lead to more severe hazardous weather in the central United States, notably increasing occurrences of heavy precipitation rates and large hail. Both heat and aerosols from wildfires play an important role. As wildfires are projected to be more severe in a warmer climate, the influence of wildfires on severe weather in downstream regions may become increasingly important.
A prospective analysis of red blood cell membrane polyunsaturated fatty acid levels and risk of non-Hodgkin lymphoma

Abstract Published studies report inconsistent associations of polyunsaturated fatty acid (PUFA) intake with non-Hodgkin lymphoma (NHL) risk. We conducted a nested case-control study in Nurses’ Health Study and Health Professionals Follow-Up Study participants to evaluate a hypothesis of inverse association of pre-diagnosis red blood cell (RBC) membrane PUFA levels with risk of NHL endpoints. We confirmed 583 NHL cases and matched 583 controls by cohort/sex, age, race and blood draw date/time. We estimated odds ratios (OR) and 95% confidence intervals (CI) for risk of NHL endpoints using logistic regression. RBC PUFA levels were not associated with all NHL risk; cis 20:2n-6 was associated with follicular lymphoma risk (OR [95% CI] per one standard deviation increase: 1.35 [1.03–1.77]), and the omega-6/omega-3 PUFA ratio was associated with diffuse large B-cell lymphoma risk (2.33 [1.23–4.43]). Overall, PUFA did not demonstrate a role in NHL etiology; the two unexpected positive associations lack clear biologic explanations.
Improved viscosity-concentration equation for emulsions of nearly spherical droplets

We propose an improved viscosity model accounting for experiments of emulsions of two immiscible liquids at arbitrary volume fractions and low shear rates. The model is based on a recursive-differential method formulated in terms of the appropriate scaling variable which emerges from an analysis of excluded volume effects in the system. This variable, called the effective filling fraction, incorporates the geometrical information of the system which determines the maximum packing and reduces to the bare filling fraction for infinitely diluted emulsions. The agreement of our model for the viscosity with experiments is remarkable for all the range of volume fractions and viscosity ratio.