Miracle-dz/UniFAR-FTUs huggingface dataset:
Snail upregulates FN and LEF transcription negatively feed backed by PPAR-gamma: a general model established for Snail to transactivate mesenchymal genes

Background Snail (SNA) is responsible for epithelial mesenchymal transition, migration and metastasis of hepatocellular carcinoma. SNA represses the transcription of the essential epithelial marker such as E-cadherin and enhances mesenchymal markers including fibronectin and lymphoid enhancer-binding factor. Our previous studies indicated that SNA, in collaboration with EGR1 and SP1, may directly activate transcription of the mesenchymal markers, matrix degradation enzyme matrix metalloproteinases (MMP9) and zinc finger E-box binding homeobox 1 (ZEB1) in HepG2 cell stimulated by the phorbol ester tumor promoter 12-O-tetradecanoyl-phorbol 13-acetate (TPA). Besides, we pinpointed a SNA binding motif (TCACA) upstream of EGR1/SP1 overlapping region on promoters. In this study, we investigated whether LEF and FN are transcriptionally regulated by SNA in a similar fashion. Moreover, a general model for SNA-upregulated mesenchymal markers is proposed.Methods RT/PCR and Western blot were used for analyzing gene expression and shRNA technology for depleting SNA. Dual luciferase assay was used for promoter activation; deletion mapping and mutagenesis were used for confirming the indicated promoter region required for transcription activation. ChIP and EMSA were used for validating the binding of the indicated transcription factor on their putative motifs. Results SNA binding motif and E/S overlapping region are required for TPA-induced transcription of LEF and FN. These were supported by TPA-induced binding of SNA and EGR-1/SP-1 on indicated promoter regions. Moreover, a peroxisome proliferator-activated receptor γ motif upstream of SNA binding motif was found to be a negatively regulatory region in TPA-induced promoter activation of FN, LEF, MMP9 and ZEB1. This was supported by that co-treatment of a PPAR-g inhibitor, GW9662, and mutation of PPAR-g binding motif enhanced TPA-induced promoter activity and expression of the aforementioned genes whereas overexpression of PPAR-g reversed it. Moreover, comprehensive screening of the SNA-upregulated mesenchymal genes revealed similar sequence architecture on the promoter regions of the candidate genes: SNA binding motif (TCACA) coupled with a downstream EGR/SP1 overlapping region and an upstream PPAR-g binding motif. Among them COX2 and COL1A1 were found to potentially exhibit the same transcription mechanisms described above. Conclusions We established a general model for SNA-upregulated mesenchymal gene expressions negatively feed backed by PPAR-g.
Global to Local: Clip-LSTM-Based Object Detection From Remote Sensing Images

Object detection from remote sensing images (RSIs) is a basic topic in the area of aviation and satellite image processing, which has great effects on geological disaster detection, agricultural planning, and land utilization. However, it is always faced with several severe difficulties. For instance, the scale of the target spans over a very wide range, and the difference between the target size and the image size is huge, as some targets only account for a dozen pixels compared with the RSI of the megapixel level. In this work, an innovative object detection network (GLNet) is proposed for remote sensing imagery. Our approach integrates global context clues extracted by the multiscale perception (MSP) module and local spatial contextual correlations encoded by Clip long short-term memory (Clip-LSTM). These rich semantic features are further exploited to design a self-adapted anchor (SA) module to alleviate the scale variations in RSIs. Extensive experiments are executed on several public easily accessed benchmarks, including DOTA, NWPU VHR-10, and DIOR. Experimental results have demonstrated that our GLNet outperforms numerous latest methods.
HOW TEACHERS' ATTITUDES IMPACT THE INCLUSIVE CLASSROOM

This paper reviews several factors impacting a teachers’ attitude toward an inclusive classroom. A teacher’s attitude is determined to be a major factor in the growth and development of students with disabilities. It is suggested that to support the increase of students with disabilities in the general classroom setting, a shift in the demeanor of teachers is necessary. Educators must examine policy and strive to enforce robust measures. Identifying concerns, providing resources and support are essential factors in improving the success of students with disabilities in an inclusive classroom.
Water Supply and Temperature Effects on Some Nutritive Constituents of Direct Sown Onion

Irrigation is a prerequisite for economical onion production under dry conditions. However, its effect on dry matter and nutrient content often remains a concern for growers. A direct sown onion hybrid was grown under open field, rain-fed and irrigated conditions for three years, investigating the effects of air temperature and water supply on some nutritive constituents. Dry matter, storage sugar, total flavonol and total polyphenol content showed strong positive correlation with average air temperature and negative correlation with water supply. However, irrigation had a positive effect on storage sugar and dry matter content. Presumably better water supply during dry periods ensured by irrigation provided the basis for higher photosynthetic production, and hereby more dry matter partitioning and accumulation in the bulb, a storage organ. An unexpected decrease in vitamin C content was experienced in 2011 and 2012, compared to the result of 2010, which was explained by the hot and dry conditions of the pre-harvest irrigation cut-off period. Fibre and ash content was found to be the most stable nutritional characteristics, affected neither by the environmental conditions, nor by the irrigation. Irrigation has proved to be very beneficial for direct sown onion, doubling bulb yield while not affecting the nutritive quality negatively.
RE-EXAMINING ANALYST SUPERIORITY IN FORECASTING RESULTS OF PUBLICLY-TRADED BRAZILIAN COMPANIES

ABSTRACT Purpose: This research examines the superiority of analysts over random walk models in forecasting the results of publicly-traded Brazilian companies in the short and long term. Originality/value: The literature indicates the uncontested superiority of market analysts because of their temporal and informational advantages. However, recent international studies call for a re-evaluation of this superiority, indicating that, for certain company characteristics, and primarily for long-term estimates, the superiority of analysts is not confirmed. Design/methodology/approach: This work evaluates the profit forecasting of analysts and simple and growth random walk models over the short and long term over 2010-2015 for publicly traded Brazilian companies, using the information available for the period with annual intervals. Findings: The results indicate: 1. the greater forecasting accuracy of simple random walk models compared to the growth random walk models; and 2. the greater forecasting accuracy of random walk models overall, with analyst forecasts only being superior for cases with three months of lag. The evidence suggests the forecasting superiority of the random walk models when compared to the market analysts' forecasts. The results suggest low efficiency of the forecasts of market analysts for the forecast of future results of publicly traded Brazilian companies in the analyzed period.
Reliability and Validity of the Turkish Version of SF-12 Health Survey.

OBJECTIVE The aim of this study is to determine the psychometric properties of the Turkish version of the SF-12 Health - a widely used scale that assesses health - related quality of life - and to assess whether its psychometric properties are as good as with the 36 items long version (SF-36). METHOD The study included a total of 190 participants including 138 young adults aged from 18 to 29 years (22.04±2.35) and 52 older adults aged from 60 to 80 years (67.27±5.22). The relationships between EQ-5D-3L, CES-D and SF-12 scales were investigated for content, convergent and divergent, criterion-related and the known-groups construct validity. In order to assess reliability, internal consistency and item-total correlation coefficients were calculated and test re-test analyses were conducted. RESULTS The internal consistency coefficients of the scale were found to be satisfactory (for the components α=0.73 and 0.72). Consistent with the original study, physical and mental components of the SF-12-TR were found to be strongly correlated with the components of the SF- 36 and explained, respectively, 86.6% and 92.4% of the variance. The components of the SF-12-TR were found to be moderately or strongly correlated to the sub-dimensions of the EQ-5D-3L and CES-D, which measure the same structures, while they were unrelated or weakly correlated with the sub-dimensions measuring different structures. CONCLUSION The findings indicated that the psychometric properties of the Turkish form of SF-12-TR are similar to the original version, and the SF-12-TR can be used as an alternative to the SF-36-TR in clinical and research settings in our country.
Personality Traits and Marital Adjustment: Interaction between Intra and Interpersonal Aspects

Abstract Personality characteristics have been evaluated due to the reflexes that they provoke in the conjugal satisfaction and adjustment. The objective of this study was to evaluate the actor-partner effects of personality traits on the conjugal adjustment of heterosexual couples. The study, quantitative and explanatory, evaluated 231 couples from different cities of Rio Grande do Sul. Respondents completed the Socio-demographic questionnaire, the Revised Dyadic Adjustment Scale and the Personality Adjectives Marker scale. The data was analyzed using the Latent Traits Model. The results indicate that socialization, neuroticism and achievement factors have an effect on the marital adjustment of husbands and wives. There is a partner effect on the wives’ neuroticism factor and on the husbands’ achievement factor. The extroversion and openness factors do not provoke actor-partner effects on the adjustment of the couples. The results are discussed in the light of other studies and research agendas are suggested.
SrB4O7:Sm2+: an optical sensor reflecting non-hydrostatic pressure at high-temperature and/or high pressure in a diamond anvil cell

ABSTRACT A systematic investigation on the fluorescent spectra of SrB4O7:Sm2+ was performed in detail at high-temperature up to 623 K and/or high pressure up to 23.2 GPa with different pressure-transmitting media (PTMs), respectively. Combined with experiment data of previous research, the change of the 7D0–5F0 line (0–0 line) full width at half maximum (FWHM) of SrB4O7:Sm2+ under different pressure environments was specifically discussed. The results indicate that the FWHM of 0–0 line is sensitive to the non-hydrostatic pressure environment in 2-propanol, and methanol and ethanol mixture (ME) PTMs at ambient temperature. The first-order and the second-order derivation of the temperature dependence of 0–0 line FWHM at ambient pressure are 1.48(±0.21) × 10−4 nm/K and 9.63(±0.63) × 10−7 nm2/K2 below 623 K. The 0–0 line FWHM is also sensitive to the non-hydrostatic pressure environment in ME at high-temperature and high pressure simultaneous, the non-hydrostatic transition pressures are 9.6 GPa at 323 K, 11.0 GPa at 373 K, 14.4 GPa at 423 K, respectively. SrB4O7:Sm2+ is recommended as an optical sensor to reflect the change of pressure environment in liquid media at high-temperature and/or high pressure.
Assessing Media Literacy Levels among Audience in Seeking and Processing Health Information during the COVID-19 Pandemic

Media plays a crucial role in information dissemination during significant social, economic, political events and crises, including epidemics Public look upon the media for credible and authentic information during such times resulting in a surge in information seeking In 1976, Sandra Ball-Rokeach and Melvin DeFleur proposed media dependency theory (Lin,2020) Audience dependency on the media increased with the rise in social conflicts, resulting in greater chances of the media’s potential effect During epidemics, media is known to spread awareness and disease mitigation efforts (Xiao et al , 2015) But in the digital age, information overload, misinformation, and rumours tend to be detrimental to such mitigation efforts The Director-General of WHO (2020) stressed the importance of facts, stating that misinformation makes health workers’ efforts challenging While social media platforms have been asked to screen fake news, the influencers have been asked to actively promote facts in their posts, as some of the measures to tackle the ‘ infodemic’ regarding COVID-19 This study uses the concept of media literacy, active audience, media dependency theory, health information-seeking behaviour, expectancy-value theory, among others, to recognize information search patterns and assess media literacy levels, including processing and verification of information by mainstream media audiences and social media users during the COVID-19 pandemic period in India © Media Watch
Determinants of gross income from carp production in Bara district, Nepal

A study was conducted from March to June 2020 to analyze the determinants of gross income from carp production in the Bara district of Nepal. Altogether, 90 carp producers, 45 each from Simraungadh and Pachrauta municipality in equal basis were sampled by using cluster sampling technique. Primary information was collected through a pre-tested semi-structured interview-based schedule while secondary information was collected reviewing the relevant publications. Data was entered in SPSS 25 and analyzed using STATA 12.1. The results revealed that the cost of labor, cost of feed, assistances and services, and training had significant positive effect on gross income from carp prodcuiton. Furthermore, lack of quality inputs was identified as the most severe production problems whereas Dhalta to be given was recognized as the most severe marketing problems. Thus, encouraging the carp producer to manage the cost of labor and cost of feed deliberately, rationally providing the assistance and services and strengthening the skills and knowledge of producer through training could significantly increase gross income from carp production.
Intravenous Anesthesia Offers a Better Overall Survival Outcomes Than Inhalation Anesthesia of Malignant Tumor After Surgery: A Meta-Analysis

Liang H1*, He J1*, Qiu S1,2#, Chen Z1#, Liu H3#, Liu H3, Lin G2, Zhang Y3, Wu X3 and Liang W1 1Department of Thoracic Surgery and Oncology, the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, Guangzhou, China 2Guangzhou Medical University, China 3Department of anesthesia, the First Affiliated Hospital of Guangzhou Medical University, China
A Single-Source Nine-Level Boost Inverter With a Low Switch Count

Switched-capacitor-based multilevel inverters for boost-type dc–ac power conversions usually exhibit a trade-off between the switch count and switch-voltage rating, i.e., a reduction of one necessitating an increase of the other. Such a dilemma is well addressed in this article by proposing a novel single-phase nine-level inverter based on a switched-capacitor network with a single switch. The proposed inverter then reduces the number of switches while generating a boosted dc-link voltage. A unique six-switch full-bridge cooperating with a low-frequency half-bridge further steps-up the output voltage with a quadruple gain. The voltage stresses on the power devices are, however, maintained low even under the boosted high output voltage, as all the switches/diodes can be clamped to any of the low-voltage capacitors. Consequently, low-voltage power devices can be utilized, reducing the overall power loss. Detailed theoretical analysis, calculations, and design considerations of the proposed inverter are provided. Comparisons with the prior-art inverters illustrate its advantages. Simulations and experimental tests on a 1-kVA inverter prototype verify the above-claimed benefits.
Centering Racial Equity in Measures of School Climate: Perspectives of Racial and Ethnic Minoritized Students

Objective: This qualitative study sought to better understand whether and how items on a school climate survey capture racial/ethnic minoritized (REM) students’ definitions and experiences of racial (in)equity. Method: We conducted three focus groups with a convenience sample of 13 REM students from Seattle Public Schools. Participants were mostly female (56%) and in high school (56%). Inductive analytic techniques informed by grounded theory were used to facilitate analysis and interpretation. Results: Participants defined and experienced racial equity as a construct based on how they are treated by others and the application of rules and expectations. School climate survey items mostly aligned with participants’ definitions and experiences of racial equity; items captured participants’ racialized interpersonal interactions and the school structures and processes that influence racially (in)equitable experiences and outcomes. Conclusions: Integrating REM students’ perspectives in measurement design and questions about race, culture, ability, and identity are critical to ensuring that school climate measures capture their experiences and perceptions of racial (in)equity. Future research should investigate REM students’ perspectives of school climate measures that embed racial equity and the outcomes from such measures.
Saprophytic flies in impacted areas of the Belo Monte Dam, Pará, Brazil (Diptera: Mesembrinellidae, Neriidae, Ropalomeridae, and Sarcophagidae): community composition, abundance, and species richness

Abstract: The present study aims to document the community composition, abundance, and species richness of saprophytic fly species (Mesembrinellidae, Neriidae, Ropalomeridae, and Sarcophagidae) of the Volta Grande region of the Xingu River, a poorly sampled area impacted by the Belo Monte hydroelectric dam. Five collecting trips were carried out between 2014 and 2016, when traps baited with fermenting bananas were used. A total of 154 specimens, three genera, and six species were collected of Mesembrinellidae; 196 specimens, three genera, and seven species of Neriidae; 272 specimens, three genera, and six species of Ropalomeridae; and 624 specimens, 22 species and 10 genera of Sarcophagidae. Species accumulation curves for all families except Sarcophagidae demonstrated a strong tendency towards stabilization, showing that sampling efforts were sufficient to record most of the targeted species. Laneela perisi (Mariluis, 1987) (Mesembrinellidae) is a new record for the state of Pará. Among Ropalomeridae, Apophorhynchus amazonensisPrado, 1966, is a new record for Pará. Among Sarcophagidae, Helicobia aurescens (Townsend, 1927) is newly recorded from the Brazilian Amazon, and Ravinia effrenata (Walker, 1861) and Titanogrypa larvicida (Lopes, 1935) are new records for Pará.
The Cycle of Violence: Abused and Neglected Girls to Adult Female Offenders

Drawing on findings from a prospective cohort design study that followed abused and neglected children and demographically matched controls into adulthood, this paper focuses on these abused and neglected girls and one important consequence—the extent to which these victims become offenders themselves. We ask four questions: Is criminal behavior among abused and neglected girls and women rare? Are abused and neglected girls at increased risk for becoming violent offenders? Does childhood maltreatment affect criminal career trajectories for girls? Do maltreated girls grow up to maltreat their own children? We conclude with discussion, suggestions for future research, and implications.
How Can Companies Decrease Salesperson Turnover Intention? The Corporate Social Responsibility Intervention

Salespeople turnover is a key issue that can threaten a company’s survival, either by reducing its income or increasing its expenses. The purpose of this study is to analyze the impact of corporate social responsibility (CSR) practices on the salespeople turnover. Drawing from social network theory, this research suggests that the perception of CSR practices influences salespeople turnover through their impact on the perception of the company’s reputation and the organizational pride that sellers experience. Additionally, the moderating role of interpersonal justice in the CSR-organizational pride relationship is analyzed. The data was collected from a sample of 176 salespeople and their supervisors from 96 companies. Structural equation modeling was used to analyze the psychometric properties of the measurement scales and to test the proposed direct hypotheses, and conditional process analysis was used to test the proposed mediation hypothesis. The results indicate that CSR is negatively related to salesperson turnover via the perceived salespeople’s organizational pride and organizational reputation. Furthermore, this study’s findings confirm the importance of a salesperson’s interpersonal justice for these relationships. This study contributes to the existing sales and management literature by enhancing our understanding of how to reduce salespeople turnover intention. Specifically, it underlines the role of CSR practices in reducing those intentions.
Profile of Pre-Service Chemistry Teacher Self-Efficacy: A Case on Rate of Reaction Topic

This study aimed to analyze the self-efficacy profile of pre-service chemistry teacher on rate of reaction topic. This research was a survey research with cross sectional research design. This study involved 90 pre-service chemistry teacher at three year levels, i.e. second year, fourth year, and sixth year at Yogyakarta State University, Indonesia. The research sample was determined using convenience sampling technique. Self-efficacy data of pre-service chemistry teacher were collected using a questionnaire. The efficacy questionnaire includes Personal Science Teaching Efficacy belief (PSTE) and Science Teaching Outcome Expectancy (STOE). Theoretical validity was carried out to see the appropriateness of the instruments used. The theoretical validity was carried out by three chemistry education experts to provide suggestions that support the improvement of the quality of research instruments. Self-efficacy profile data analysis techniques were analyzed descriptively quantitative. The results showed that the self-efficacy of pre-service chemistry teacher who attended lectures in the second year was better than that of the fourth and sixth year. This study shows that the year level does not affect the high self-efficacy of pre-service chemistry teacher.
Does managerial entrenchment affect audit report lag?

* Corresponding author, Jack H. Brown College of Business and Public Administration, California State University, San Bernardino, California, the USA Contact details: California State University, 5500 University Parkway, San Bernardino, CA 92407, the USA ** Earl G. Graves School of Business and Management, Morgan State University, Baltimore, Maryland, the USA *** College of Business and Economics, Towson University, Towson, Maryland, the USA