Miracle-dz/UniFAR-FTUs huggingface dataset:
circ_0058063 promotes breast cancer progression by upregulating DLGAP5 via sponging miR-557

OBJECTIVE: Accumulating evidence indicates that circular RNAs (circRNAs) contribute to breast cancer (BC) development and progression. However, the role of circ_0058063 in BC and its underlying molecular processes remain unclear. METHODS: The expression of circ_0058063, miR-557, and DLGAP5 in BC tissues and cells was determined using real time quantitative PCR or western blotting. The functions of circ_0058063 in BC cells were detected using CCK-8, Transwell, caspase-3 activity, and xenograft tumor assays. The specific binding of circ_0058063/miR-557 and DLGAP5/miR-557 was verified using RNA immunoprecipitation (RIP) and dual-luciferase reporter assays. RESULTS: circ_0058063 expression was upregulated in BC tissues and cells. circ_0058063 knockdown inhibited proliferation and migration but promoted apoptosis in MCF-7 and MDA-MB-231 cells in vitro. In vivo studies further validated that the knockdown of circ_0058063 repressed tumor growth. Mechanistically, circ_0058063 directly sponged miR-557 and negatively regulated its expression. Additionally, miR-557 inhibition reversed the tumor-suppressive effects of the circ_0058063 knockdown on the survival of MDA-MB-231 and MCF-7 cells. Moreover, miR-557 directly targeted DLGAP5. DLGAP5 knockdown suppressed MCF-7 and MDA-MB-231 cell growth, and these effects were reversed by miR-557 downregulation. CONCLUSION: Our findings verify that circ_0058063 acts as a sponge for miR-557 to upregulate DLGAP5 expression. These findings suggest that the circ_0058063/miR-557/DLGAP5 axis is an important regulator of oncogenic function and may be a promising therapeutic target for BC.
Application of non‐invasive bioreactance to assess hemodynamic function in patients with hypertrophic cardiomyopathy

Non‐invasive technologies have become popular for the clinical evaluation of cardiac function. The present study evaluated hemodynamic response to cardiopulmonary exercise stress testing using bioreactance technology in patients with hypertrophic cardiomyopathy. The study included 29 patients with HCM (age 55 ± 15 years; 28% female) and 12 age (55 ± 14 years), and gender matched (25% female) healthy controls. All participants underwent maximal graded cardiopulmonary exercise stress testing with simultaneous non‐invasive hemodynamic bioreactance and gas exchange. At rest, patients with HCM demonstrated significantly lower cardiac output (4.1 ± 1.3 vs. 6.1 ± 1.2 L/min; p < 0.001), stroke volume (61.5 ± 20.8 vs. 89.5 ± 19.8 mL/beat; p < 0.001), and cardiac power output (0.97 ± 0.3 vs. 1.4 ± 0.3watt; p < 0.001), compared to controls. At peak exercise, the following hemodynamic and metabolic variables were lower in HCM patients that is, heart rate (118 ± 29 vs. 156 ± 20 beats/min; p < 0.001), cardiac output (15.5 ± 5.8 vs. 20.5 ± 4.7 L/min; p = 0.017), cardiac power output (4.3 ± 1.6 vs. 5.9 ± 1.8 watts; p = 0.017), mean arterial blood pressure (126 ± 11 vs. 134 ± 10 mmHg; p = 0.039), and oxygen consumption (18.3 ± 6.0 vs. 30.5 ± 8.3 mL/kg/min; p < 0.001), respectively. Peak arteriovenous oxygen difference and stroke volume were not significantly different between HCM patients and healthy controls (11.2 ± 6.4 vs. 11.9 ± 3.1 mL/100 mL, p = 0.37 and 131 ± 50.6 vs. 132 ± 41.9 mL/beat, p = 0.76). There was a moderate positive relationship between peak oxygen consumption and peak heart rate (r = 0.67, p < 0.001), and arteriovenous oxygen difference (r = 0.59, p = 0.001). Functional capacity is significantly reduced in patients with HCM primarily due to diminished central (cardiac) rather than peripheral factors. Application of non‐invasive hemodynamic assessment may improve understanding of the pathophysiology and explain mechanisms of exercise intolerance in hypertrophic cardiomyopathy.
Acute effects of a single neurodynamic mobilization session on range of motion and H‐reflex in asymptomatic young subjects: A controlled study

Neurodynamic techniques have yielded good clinical results in the treatment of various pathologies. The objective of this study is to examine the short‐term effects of neurodynamic techniques of the sciatic nerve on hip ROM (range of motion) and on the amplitude and latency of the soleus H‐reflex and M‐waves, in young asymptomatic subjects. In a double‐blind controlled trial design, 60 young asymptomatic participants were randomly assigned into six groups with different levels of manipulation of the sciatic nerve. The passive straight leg raise test was used to evaluate the hip ROM amplitude. All evaluations were performed before, 1 min after, and 30 min after intervention. For each time‐point, spinal and muscle excitability were also tested. ROM increased in all groups, but none of the treatment groups had superior effects than the group with no treatment. This means that ROM testing maneuvers increased ROM amplitude, with no add‐on effect of the proposed neurodynamic techniques. Neurophysiological responses changed similarly in all groups, showing that the aftereffects were not intervention‐specific. We observed a significant negative association between the change in limb temperature and the change in latencies of all potentials. ROM‐testing procedures performed repeatedly increase ROM amplitude. This observation should be considered when evaluating the aftereffects of therapeutic interventions on ROM amplitude. None of the explored neurodynamic techniques produced acute aftereffects on hip ROM amplitude, spinal or muscle excitability different to the induced by the ROM testing maneuver.
Multivariate monotone likelihood ratio and uniform conditional stochastic order

Karlin and Rinott (1980) introduced and investigated concepts of multivariate total positivity (TP2) and multivariate monotone likelihood ratio (MLR) for probability measures on Rn These TP and MLR concepts are intimately related to supermodularity as discussed in Topkis (1968), (1978) and the FKG inequality of Fortuin, Kasteleyn and Ginibre (1971). This note points out connections between these concepts and uniform conditional stochastic order (ucso) as defined in Whitt (1980). ucso holds for two probability distributions if there is ordinary stochastic order for the corresponding conditional probability distributions obtained by conditioning on subsets from a specified class. The appropriate subsets to condition on for ucso appear to be the sublattices of Rn . Then MLR implies ucso, with the two orderings being equivalent when at least one of the probability measures is TP2.
Partial differential equations and stochastic methods in molecular dynamics*

The objective of molecular dynamics computations is to infer macroscopic properties of matter from atomistic models via averages with respect to probability measures dictated by the principles of statistical physics. Obtaining accurate results requires efficient sampling of atomistic configurations, which are typically generated using very long trajectories of stochastic differential equations in high dimensions, such as Langevin dynamics and its overdamped limit. Depending on the quantities of interest at the macroscopic level, one may also be interested in dynamical properties computed from averages over paths of these dynamics. This review describes how techniques from the analysis of partial differential equations can be used to devise good algorithms and to quantify their efficiency and accuracy. In particular, a crucial role is played by the study of the long-time behaviour of the solution to the Fokker–Planck equation associated with the stochastic dynamics.
The far-reaching burden of Hyperemesis Gravidarum – an exploration of women’s experiences and perceptions of healthcare support

ABSTRACT Hyperemesis Gravidarum (HG) is a rare condition of pregnancy that exerts a profound effect on a woman’s physical and psychological health, but limited research regarding women’s perceptions of healthcare for this condition exists. The aim of this study was to gain insight into the personal and healthcare experiences of women with HG. Eligible participants included women who had experienced HG in a current or recent pregnancy and were referred to the dietitian at the National Maternity Hospital, Dublin, Ireland. Suitable women were invited to participate by letter, with a follow-up phone call to confirm eligibility. Four semi-structured focus groups were conducted (n = 11). Audio recordings were transcribed and data was thematically analyzed using an inductive, data-driven approach. Participants emphasized the psychological hardship of HG, which manifested in many different ways, and unveiled the far-reaching burden of HG. Women advocated for a dedicated service for HG and the need for increased knowledge, understanding and support for HG, in order to ensure optimal HG management and woman-centered care. Women also highlighted the need for obvious clinical leadership of HG and a continuum of care throughout pregnancy and post-partum. Improvements to the day ward setting and access to HG-specific mental health support would be welcomed. At a government level, timely resolution of the financial assistance for first-line anti-emetics is needed. Overall, greater awareness and understanding of the condition is needed to improve support from family, friends and colleagues. Further research is warranted to determine whether these recommendations would result in improved pregnancy outcomes.
Sleep and Circadian Rhythm Dysfunction in Animal Models of Huntington’s Disease

Sleep and circadian disruption affects most individuals with Huntington’s disease (HD) at some stage in their lives. Sleep and circadian dysregulation are also present in many mouse and the sheep models of HD. Here I review evidence for sleep and/or circadian dysfunction in HD transgenic animal models and discuss two key questions: 1) How relevant are such findings to people with HD, and 2) Whether or not therapeutic interventions that ameliorate deficits in animal models of HD might translate to meaningful therapies for people with HD.
Chronic disease multimorbidity and substance use among African American men: veteran-non-veteran differences

ABSTRACT Objectives: The purpose of the study was to explore the extent to which prior military service may moderate the relationship between chronic disease multimorbidity and substance use among African American men in the United States. Design: Data for this cross-sectional study was downloaded from the 2016 –2019 United States (US) National Survey on Drug Use and Health. We estimated three survey-weighted multivariable logistic regression models, where use of each of the following substances served as the dependent variables: illicit drugs, opioids, and tobacco. Differences in these outcomes were examined along two primary independent variables: veteran status and multimorbidity (and an interaction term for these variables). We also controlled for the following covariates: age, education, income, rurality, criminal behavior, and religiosity. Results: From the 37,203,237 (weighted N) African American men in the sample, approximately 17% reported prior military service. Veterans with ≥ 2 chronic diseases had higher rates of illicit drug use (aOR = 1.37, 95% CI = 1.01, 1.87; 32% vs. 28%) than non-veterans with ≥ 2 chronic diseases. Non-veterans with one chronic disease had higher rates of tobacco use (aOR = 0.80, 95% CI = 0.69, 0.93; 29% vs. 26%) and opioid misuse (aOR = 0.49, 95% CI = 0.36, 0.67; 29% vs. 18%) than veterans with one chronic disease. Discussion: Chronic disease multi-morbidity appears to be a context in which African American veterans may be at greater risk for certain undesirable health behaviors than African American non-veterans and at lower risk for others. This may be due to exposure to trauma, difficulty accessing care, socio-environmental factors, and co-occurring mental health conditions. These complex interactions may contribute to higher rates of SUDs among African American veterans compared to African American non-veterans.
Thrust Evaluation of Magneto Plasma Sail by Using Three-Dimensional Hybrid PIC Code.

Magneto Plasma Sail (MPS) is a propulsion system used in space, which generates its force by the interaction between solar wind and an inflated magnetic field via a plasma injection. The quantitative evaluation of the thrust increment generated by injecting a plasma jet with a βin less than unity was conducted by three-dimensional hybrid particle-incell (PIC) simulations in an ion inertia scale. The injected plasma beta βin is 0.02 and the ratio of Larmor radius of injected ion to the representative length of the magnetic field is 0.5 at the injection point. In this situation, the obtained thrust of the MPS is 1.6 mN compared with the 0.2 mN of the thrust obtained by the pure magnetic sail since the induced current region on magnetosphere expanded by the magnetic inflation. The magnetic inflation was achieved by the loop-like current induced by the isotropic injection of plasma with grad B drift motion having the same direction as the original coil current.
The effects of ergonomic sleep mask use on sleep quality and comfort in intensive care patients

This study was conducted to determine the effects of the use of ergonomic sleep mask on sleep quality and comfort in intensive care patients. This randomised controlled experimental study was completed with 128 surgical intensive care patients (control = 64, experimental = 64). During the second night of their stay in the unit, ergonomic sleep masks were given to the patients in the experimental group, and earplugs and eye masks were given to the patients in the control group. A Patient information form, Visual analogue scale for discomfort, and the Richard‐Campbell sleep questionnaire were used to collect data. While 51.6% of the patients were female, the mean age of the patients was 63.87 ± 14.94 years. The highest rates of patients had undergone cardiovascular surgery (28.9%) and general anaesthesia (57.8%). It was determined that the sleep quality of the patients in the experimental group was statistically and clinically significantly higher after the intervention (50.86 ± 21.46 vs 37.64 ± 14.97, t = −5.355, Cohen's d = 0.450, p < 0.001). Likewise, the patients who used ergonomic sleep masks had a statistically significantly lower mean VAS for Discomfort score, and their comfort level was higher (p < 0.001), but the difference was not clinically significant (Cohen's d = 0.208). The results of this study showed that the use of ergonomic sleep masks in surgical intensive care patients had a more positive effect on both the sleep quality and comfort levels of patients compared with earplugs and eye masks. The use of an ergonomic sleep mask is recommended in the early period to facilitate sleep and rest in surgical intensive care patients.
The association of religious factors with mental health-service utilisation and satisfaction in a mixed Sámi and Norwegian adult population: Adopting the SAMINOR 2 Questionnaire Survey

ABSTRACT The Indigenous Sámi have poorer mental health than the majority population and fairly equal access to professional mental healthcare. Despite this condition, certain studies indicate that this group is underrepresented among the users of such services. Religion or spirituality (R/S) often influences mental health-service utilisation and satisfaction among other Indigenous peoples and ethnic minorities. Thus, this study examines the situation in Sámi-Norwegian areas. We utilised cross-sectional data from the population-based SAMINOR 2 Questionnaire Survey (2012; subsample n = 2,364; 71% non-Sámi) in mixed Sámi-Norwegian regions of Northern and Central Norway. We analysed the associations between R/S factors and past-year mental health-service utilisation and satisfaction among individuals reporting mental health problems, substance use, or addictive behaviours. Multivariable-adjusted regression models considering sociodemographic factors, including Sámi ethnicity, were applied. Religious attendance was significantly associated with infrequent past-year use of mental health services (OR = 0.77) and fewer mental health problems, indicating that the R/S fellowship may buffer mental distress and represent an alternative psychological support to professional services. R/S was not significantly associated with lifetime mental health-service satisfaction. We found no ethnic differences in service utilisation or satisfaction.
Dosimetry for Computed Tomography Examination of Children

The increased use of computed tomography and the relatively high radiation doses makes it important to evaluate the absorbed dose to the patient, especially for children. In this study measurement results obtained with an anthropomorphic phantom simulating a one year old child have been compared with two different methods for the calculation of the absorbed dose. The results agree within ±15%. The limitations and benefits of the methods used are discussed.
Relevance of silicate surface morphology in interstellar H2 formation. Insights from quantum chemical calculations

The adsorption of H atoms and their recombination to form an H2 molecule on slab models of the crystalline Mg2SiO4 forsterite (001) and (110) surfaces was studied by means of quantum mechanical calculations based on periodic density functional theory (DFT). Present results are compared with those previously reported for the most stable (010) surface, showing the relevance of the surface morphology and their stability on the H2 formation. Different H chemisorption states were identified, mostly on the outermost O atoms of the surfaces. In agreement with the higher instability of the (001) and (110) surfaces, the calculated adsorption energies are larger than those for the (010) surface. Computed energy barriers for the H hopping on these surfaces are exceedingly high to occur at the very low temperatures of deep space. For the adsorption of two H atoms, the most stable complexes are those in which the H atoms form Mg-H and SiOH surface groups. From these complexes, we did not identify energetically feasible paths for H2 formation through a Langmuir–Hinshelwood mechanism on the (001) surface because the initial states are more stable than the final products. However, on the (110) surface one path was found to be exoergic with very low energy barriers. This differs to that observed for the (010) surface, for which two feasible Langmuir–Hinshelwoodbased channels were identified. H2 formation through the Eley–Rideal mechanism was also simulated, in which an incoming H atom impinges on a pre-adsorbed H atom at the (001) and (110) surfaces in a barrierless way.
On turbulent particle fountains

We describe new experiments in which particle-laden turbulent fountains with source Froude numbers $20>Fr_{0}>6$ are produced when particle-laden fresh water is injected upwards into a reservoir filled with fresh water. We find that the ratio $U$ of the particle fall speed to the characteristic speed of the fountain determines whether the flow is analogous to a single-phase fountain ( $U\ll 1$ ) or becomes a fully separated flow ( $U\geqslant 1$ ). In the single-phase limit, a fountain with momentum flux $M$ and buoyancy flux $B$ oscillates about the mean height, $h_{m}=(1.56\pm 0.04)M^{3/4}B^{-1/2}$ , as fluid periodically cascades from the maximum height, $h_{t}=h_{m}+{\rm\Delta}h$ , to the base of the tank. Experimental measurements of the speed $u$ and radius $r$ of the fountain at the mean height $h_{m}$ , combined with the conservation of buoyancy, suggest that $Fr(h_{m})=u(g^{\prime }r)^{-1/2}\approx 1$ . Using these values, we find that the classical scaling for the frequency of the oscillations, ${\it\omega}\sim BM^{-1}$ , is equivalent to the scaling $u(h_{m})/r(h_{m})$ for a fountain supplied at $z=h_{m}$ with $Fr=1$ (Burridge & Hunt, J. Fluid Mech., vol. 728, 2013, pp. 91–119). This suggests that the oscillations are controlled in the upper part of the fountain where $Fr\leqslant 1$ , and that they may be understood in terms of a balance between the upward supply of a growing dense particle cloud, at the height where $Fr=1$ , and the downward flow of this cloud. In contrast, in the separated flow regime, we find that particles do not reach the height at which $Fr=1$ : instead, they are transported to the level at which the upward speed of the fountain fluid equals their fall speed. The particles then continuously sediment while the particle-free fountain fluid continues to rise slowly above the height of particle fallout, carried by its momentum.
Investigation of wind tunnel model deformation under high Reynolds number aerodynamic loading

The twist shapes adopted by wind tunnel model wings under tunnel loads can have a significant effect on the vortex drag levels measured for typical airliner designs, yet are difficult to predict theoretically or to measure experimentally. The problem of accurately determining model twist shapes becomes particularly important when tests are performed in pressurised test facilities, which typically feature large wind-off to wind-on wing twist changes. In such tests, percentage twist errors which would be negligibly small in atmospheric testing can be magnified to a point where they have a marked effect on aerodynamic force measurements. This paper describes work recently performed at Airbus UK to determine the twist shapes adopted by a research model wing at a range of test conditions in the European Transonic Windtunnel (ETW). The task involved developing a finite element model incorporating a simplified representation of the model wing's internal structure, then validating it against data from a series of bench tests performed on the tunnel model. The validated finite element model has since been used to calculate the shape of the wing at a range of test conditions encountered during testing within the EU Fifth Framework programme HiReTT. It has also demonstrated the accuracy of the methodology used by Airbus UK to define the build shape of wind tunnel models.
Acupuncture and Doxylamine–Pyridoxine for Nausea and Vomiting in Pregnancy

BACKGROUND An effective and safe treatment for nausea and vomiting of pregnancy (NVP) is lacking. OBJECTIVE To assess the efficacy and safety of acupuncture, doxylamine-pyridoxine, and a combination of both in women with moderate to severe NVP. DESIGN Multicenter, randomized, double-blind, placebo-controlled, 2 × 2 factorial trial. (ClinicalTrials.gov: NCT04401384). SETTING 13 tertiary hospitals in mainland China from 21 June 2020 to 2 February 2022. PARTICIPANTS 352 women in early pregnancy with moderate to severe NVP. INTERVENTION Participants received daily active or sham acupuncture for 30 minutes and doxylamine-pyridoxine or placebo for 14 days. MEASUREMENTS The primary outcome was the reduction in Pregnancy-Unique Quantification of Emesis (PUQE) score at the end of the intervention at day 15 relative to baseline. Secondary outcomes included quality of life, adverse events, and maternal and perinatal complications. RESULTS No significant interaction was detected between the interventions (P = 0.69). Participants receiving acupuncture (mean difference [MD], -0.7 [95% CI, -1.3 to -0.1]), doxylamine-pyridoxine (MD, -1.0 [CI, -1.6 to -0.4]), and the combination of both (MD, -1.6 [CI, -2.2 to -0.9]) had a larger reduction in PUQE score over the treatment course than their respective control groups (sham acupuncture, placebo, and sham acupuncture plus placebo). Compared with placebo, a higher risk for births with children who were small for gestational age was observed with doxylamine-pyridoxine (odds ratio, 3.8 [CI, 1.0 to 14.1]). LIMITATION The placebo effects of the interventions and natural regression of the disease were not evaluated. CONCLUSION Both acupuncture and doxylamine-pyridoxine alone are efficacious for moderate and severe NVP. However, the clinical importance of this effect is uncertain because of its modest magnitude. The combination of acupuncture and doxylamine-pyridoxine may yield a potentially larger benefit than each treatment alone. PRIMARY FUNDING SOURCE The National Key R&D Program of China and the Project of Heilongjiang Province "TouYan" Innovation Team.