Miracle-dz/UniFAR-FTUs huggingface dataset:
A phase 2 study of GVAX colon vaccine with cyclophosphamide and pembrolizumab in patients with mismatch repair proficient advanced colorectal cancer

Mismatch repair proficient (MMRp) colorectal cancer (CRC) has been refractory to single‐agent programmed cell death protein 1 (PD1) inhibitor therapy. Colon GVAX is an allogeneic, whole‐cell, granulocyte‐macrophage colony‐stimulating factor ‐secreting cellular immunotherapy that induces T‐cell immunity against tumor‐associated antigens and has previously been studied in combination with low‐dose cyclophosphamide (Cy) to inhibit regulatory T cells.
Age‐related structural and functional variations in 5,967 individuals across the adult lifespan

Exploring brain changes across the human lifespan is becoming an important topic in neuroscience. Though there are multiple studies which investigated the relationship between age and brain imaging data, the results are heterogeneous due to small sample sizes and relatively narrow age ranges. Here, based on year-wise estimation of 5967 subjects from 13 to 72 years old, we aimed to provide a more precise description of adult lifespan variation trajectories of gray matter volume (GMV), structural network correlation (SNC) and functional network connectivity (FNC) using independent component analysis and multivariate linear regression model. Our results revealed the following relationships: 1)GMV linearly declined with age in most regions, while parahippocampus showed an inverted U-shape quadratic relationship with age; SNC presented a U-shape quadratic relationship with age within cerebellum, and inverted U-shape relationship primarily in the default mode network (DMN) and frontoparietal (FP) related correlation. 2) FNC tended to linearly decrease within resting-state networks (RSNs), especially in visual network and DMN. Early increase was revealed between RSNs, primarily in FP and DMN, which experienced decrease at older ages. U-shape relationship was also revealed to compensate for the cognition deficit in attention and subcortical related connectivity at late years. 3) The link between middle occipital gyrus and insula, as well as precuneus and cerebellum, exhibited similar changing trends between SNC and FNC across the adult lifespan. Collectively, these results highlight the benefit of lifespan study and provide a precise description of age-related regional variation and SNC/FNC changes based on a large dataset.
Incidence of Radioembolization-Induced Liver Disease and Liver Toxicity Following Repeat 90Y-Radioembolization: Outcomes at a Large Tertiary Care Center.

PURPOSE The complication profile following repeat Y-radioembolization (RE) is not well understood, and repeat RE is sometimes avoided because of concerns for RE-induced liver disease (REILD) and liver toxicity. The purpose of this study was to examine the incidence of REILD and liver toxicity following repeat Y-RE and to identify potential risk factors. METHODS A retrospective analysis of patients undergoing repeat RE to the same hepatic lobe between 2013 and 2018 was performed. Baseline factors were evaluated as predictors of liver toxicity, mortality, and REILD, which was defined as the presence symptomatic ascites or jaundice in the absence of biliary obstruction within 8 weeks following RE. Post-RE complications were graded according to the Common Terminology Criteria for Adverse Events version 5. RESULTS A total of 39 patients underwent repeat RE with 14 (35.9%) experiencing Common Terminology Criteria for Adverse Events toxicity of grade 2 or greater, 3 (10.3%) grade 3, and no grade 4 or greater. A Model for End Stage Liver Disease score of 8 or greater was associated with grade 2 toxicity or greater (26.7% vs 75%; P = 0.013). Only 3 patients (7.7%) experienced REILD due to symptomatic ascites without jaundice. Greater than 2 REs were associated with a greater rate of 6-month mortality (12% vs 58.3%, P = 0.003), 12-month mortality (28% vs 75%, P = 0.007), and REILD (0% vs 21.4%, P = 0.016). Age, sex, microsphere type, cirrhosis, Child-Pugh, and Eastern Cooperative Oncology Group status were not significantly associated with complications, REILD, or survival. CONCLUSIONS Repeat Y-RE appears to be well tolerated with a low rate of high-grade adverse events and REILD.
Magnetic Resonance Kidney Parenchyma-T2 as a Novel Imaging Biomarker for Autosomal Dominant Polycystic Kidney Disease.

OBJECTIVE Autosomal dominant polycystic kidney disease (ADPKD) is a chronic progressive disorder with a significant disease burden leading to end-stage renal disease in more than 75% of the affected individuals. Although prediction of disease progression is highly important, all currently available biomarkers-including height-adjusted total kidney volume (htTKV)-have important drawbacks in the everyday clinical setting. Thus, the purpose of this study was to evaluate T2 mapping as a source of easily obtainable and accurate biomarkers, which are needed for improved patient counseling and selection of targeted treatment options. MATERIALS AND METHODS A total of 139 ADPKD patients from The German ADPKD Tolvaptan Treatment Registry and 10 healthy controls underwent magnetic resonance imaging on a clinical 1.5-T system including acquisition of a Gradient-Echo-Spin-Echo T2 mapping sequence. The ADPKD patients were divided into 3 groups according to kidney cyst fraction (0%-35%, 36%-70%, >70%) as a surrogate marker for disease severity. The htTKV was calculated based on standard T2-weighted imaging. Mean T2 relaxation times of both kidneys (kidney-T2) as well as T2 relaxation times of the residual kidney parenchyma (parenchyma-T2) were measured on the T2 maps. RESULTS Calculation of parenchyma-T2 was 6- to 10-fold faster than determination of htTKV and kidney-T2 (0.78 ± 0.14 vs 4.78 ± 1.17 minutes, P < 0.001; 0.78 ± 0.14 vs 7.59 ± 1.57 minutes, P < 0.001). Parenchyma-T2 showed a similarly strong correlation to cyst fraction (r = 0.77, P < 0.001) as kidney-T2 (r = 0.76, P < 0.001), the strongest correlation to the serum-derived biomarker copeptin (r = 0.37, P < 0.001), and allowed for the most distinct separation of patient groups divided according to cyst fraction. In contrast, htTKV showed an only moderate correlation to cyst fraction (r = 0.48, P < 0.001). These observations were even more evident when considering only patients with preserved kidney function. CONCLUSIONS The rapidly assessable parenchyma-T2 shows a strong association with disease severity early in disease and is superior to htTKV when it comes to correlation with renal cyst fraction.
CIA_A_201403 935..945

1Faculty of Medicine, University of Belgrade, Belgrade, Serbia; 2Clinical Department of Geriatrics, “Zvezdara” University Hospital, Belgrade, Serbia; 3Cardiology Clinic, Clinical Center of Serbia, Belgrade, Serbia; 4Clinical Department of Cardiology, “Zvezdara” University Hospital, Belgrade, Serbia; 5Department of Physical Medicine and Rehabilitation, “Zvezdara” University Hospital, Belgrade, Serbia Purpose: Previous research has shown that poor health-related quality of life (HRQOL) is associated with adverse long-term prognosis in patients with heart failure (HF); however, there have been inconsistencies among studies and not all of them confirmed the prognostic value of HRQOL. In addition, few studies involved elderly patients and most focused on allcause mortality and HF-related hospitalization as outcomes. The aim of our study was to determine whether HRQOL is a predictor and an independent predictor of long-term cardiac mortality, all-cause mortality, and HF-related rehospitalization in elderly patients hospitalized with HF. Patients and methods: This prospective observational study included 200 elderly patients hospitalized with HF in Serbia. HRQOL was measured using the Minnesota Living with Heart Failure questionnaire (MLHFQ). The median follow-up period was 28 months. The primary outcome was cardiac mortality, and all-cause mortality and HF-related rehospitalization were secondary outcomes. Survival analysis was conducted using the Kaplan–Meier method and Cox-proportional hazards regression. Results: Subjects with poor HRQOL (higher than the median MLHFQ score) had a higher probability of cardiac mortality (P=0.029) and HF-related rehospitalization (P=0.001) during long-term follow-up. Poor HRQOL was an independent predictor of cardiac mortality (HR: 2.051, 95% CI: 1.260–3.339, P=0.004), all-cause mortality (HR: 1.620, 95% CI: 1.076–2.438, P=0.021), and HF-related rehospitalization (HR: 2.040, 95% CI: 1.290–3.227, P=0.002). Conclusion: HRQOL is an independent predictor of long-term cardiac mortality in elderly patients hospitalized with HF. It also independently predicts all-cause mortality and HFrelated rehospitalization. HRQOL could be used as a complementary clinical predictive tool in this patient population.
Reply

With great interest, we read the commentary by Dr. Ryu Watanabe. This commentary highlights the main findings of our recent study that demonstrates the biased mal-differentiation of Th1 and Th17 cells in patients with Takayasu's arteritis (TAK) and identifies mTORC1 hyperactivity as the T cell-intrinsic mechanism [1]. Accordingly, targeting mTORC1 efficiently abrogates the pro-inflammatory T cell differentiation and ameliorates arterial inflammation in humanized TAK model [1].
Potential impact of BMI on the aggressiveness of presentation and clinical outcome of Differentiated Thyroid Cancer.

BACKGROUND Obesity is a risk factor for several cancers including Differentiated Thyroid Cancer (DTC). Moreover, it has also been investigated as a potential risk factor for aggressiveness of DTC, but the data gathered so far are conflicting. The aim of our study was to evaluate the relationship between body mass index (BMI), aggressiveness of DTC at the diagnosis and clinical outcome. METHODS We evaluated 1058 consecutive DTC patients treated with total thyroidectomy and enrolled at the time of the first 131I treatment. Patients were divided into four groups based on their BMI: Underweight (<18.5 kg/m2), normal weight (18.5-24.9 kg/m2), overweight (25-29.9 kg/m2) and obese (≥ 30 kg/m2). Histological aggressiveness of DTC at the time of diagnosis and clinical outcome according to 2015 ATA guidelines were evaluated. RESULTS No differences in histological features, ATA risk of recurrence, activity of radioiodine administered and prevalence of 131I avid metastatic disease after the first131I treatment, have been demonstrated among the groups. Furthermore, at the end of follow up (median = 5.7 years), no differences were evident in the number of further treatments performed as well as in the clinical response. CONCLUSIONS In our study group of Caucasian subjects, we could not demonstrate any association between BMI and aggressiveness of DTC, neither at the time of diagnosis nor during follow up. These data indicate that post-surgical assessment and therapeutic attitude for treatment and follow up of DTC should be based on the class of risk applied to the general population, with no concern for BMI.
MASKCONVNET: TRAINING EFFICIENT CONVNETS

In this paper, we propose a framework, called MaskConvNet, for ConvNets filter pruning. MaskConvNet provides elegant support for training budget-aware pruned networks from scratch, by adding a simple mask module to a ConvNet architecture. MaskConvNet enjoys several advantages (1) Flexible, the mask module can be integrated with any ConvNets in a plug-and-play manner. (2) Simple, the mask module is implemented by a hard Sigmoid function with small number of trainable mask variables, adding negligible memory and computational overheads to the networks during training. (3) Effective, it is able to achieve competitive pruning rate while maintaining comparable accuracy with the baseline ConvNets without pruning, regardless of the datasets and ConvNet architectures used. (4) Fast, it is observed that the number of training epochs required by MaskConvNet is close to training a baseline without pruning. (5) Budget-aware, with a sparsity budget on target metric (e.g. model size and FLOP), MaskConvNet is able to train in a way that the optimizer can adaptively sparsify the network and automatically maintain sparsity level, till the pruned network produces good accuracy and fulfill the budget constraint simultaneously. Results on CIFAR10 and ImageNet with several ConvNet architectures show that MaskConvNet works competitively well compared to previous pruning methods, with budgetconstraint well respected. Code is available at https://www.dropbox. com/ s/c4zi3n7h1bexl12/maskconv-iclr-code.zip? dl=0. We hope MaskConvNet, as a simple and general pruning framework, can address the gaps in existing literate and advance future studies to push the boundaries of neural network pruning.
Intergenerational efeet of edueation reform: mother’s edueation and ehildren’s human eapital in Nepal

We examine a potential intergenerational transfer of human capital by investigating the effect of maternal education on children’s educational and labor outcomes in the context of a developing country Nepal. To account for endogeneity of mother’s education, we use education reform in the 1970s that had differential impact on women due to their year and district of birth. We also account for birth order effects by implementing a triple-difference strategy. The education reform increased schooling of females that were most affected by the reform. Furthermore, an increase in mother’s highest level of schooling increased the child’s probability of finishing 5 grade only among mothers from a higher caste households. We find modest effects of mother’s education on child labor outcomes, with the IV estimate indicating that a year increase in mother’s education reduces a child’s weekly work by approximately an hour. A lack of intergenerational impact among relatively lower caste households suggests that exclusionary social structure should be considered when promoting maternal education as a medium to improve children’s well-being.
Chlorhexidine mouthrinse in combination with an SLS- containing dentifrice and a dentifrice slurry

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Clinical Characteristics of 76 Patients with IgG4-Related Hypophysitis: A Systematic Literature Review

Background IgG4-related hypophysitis (IgG4-RH) is a rare disease, and its prevalence remains unclear. In recent years, an increasing number of cases have been reported because of the increasing recognition of this disease. We aimed to summarize case reports of IgG4-RH and outline the clinical features and outcomes. Methods We performed PubMed search of articles using the search terms “hypophysitis [AND] IgG4. ” Consequently, only 54 English articles (76 cases) met Leporati's diagnostic criteria. Results Of the 76 cases, the ratio of men to women was 1.5 : 1, and the age at diagnosis was 54.1 ± 17.8 years. The median IgG4 concentration was 405.0 mg/dl. Anterior hypopituitarism, isolated central diabetes insipidus, and panhypopituitarism were observed in 14 (18.4%), 12 (15.8%), and 44 (57.9%) cases, respectively. The sequence of anterior hormone deficiency was as follows: gonadotropin (68.4%), ACTH (63.2%), TSH (59.2%), GH (48.7%), and prolactin (42.1%). The median number of involved organs was 1.5, and the lung (18.4%), retroperitoneum (17.1%), kidney (15.8%), submandibular glands (14.5%), and pancreas (13.2%) were the common involved organs. Elevated IgG4 concentration and normal IgG4 level were in 42 (76.4%) and 13 (23.6%) cases, respectively. Patients with elevated serum IgG4 concentration were older (60.9 ± 14.3 vs 45.6 ± 17.4, p=0.001) and male-prone (78.6% vs 40.4%, p=0.003) and had a susceptibility of multiple organ involvement (78.6% vs 35.0%, p=0.001) compared to those with normal serum IgG4 levels. Males were older at disease onset (61.5 ± 12.6 vs 42.9 ± 18.8, p < 0.001) and had a higher IgG4 concentration (425.0 vs 152.5, p=0.029) and a greater number of involved organs (2.0 vs 0.0, p=0.001), while isolated hypophysitis was more prominent in female (63.3% vs 26.1%, p=0.001). Conclusion In this review, we found that there were different characteristics between different genders. Patients with elevated serum IgG4 level in terms of some clinical features were also different from those with normal serum IgG4 level. However, the data in this review were limited by bias and confounding. Further clinical studies with larger sample sizes are warranted.
OPTO_A_220615 145..149

BP Koirala Lions Centre for Ophthalmic Studies, Maharajgunj Medical Campus, Institute of Medicine, Kathmandu, Nepal Purpose: This study was conducted primarily to measure sub-foveal choroidal thickness (SFCT) in healthy Nepalese population. Also, the correlation of SFCT with age, inter-eye difference of SFCT, inter-gender variation and inter-ethnic variation of SFCT was observed. Materials and methods: A cross-sectional, hospital based study in 162 participants (324 eyes) of six ethnic groups (Brahmin, Chhetri, Newar, Tamang, Muslim, and Gurung) was conducted. The mean age of participants was 37.37 ± 15.02 years. All the participants underwent SFCT measurement using Spectral Domain Optical Coherence Tomography (Spectralis HRA +OCT, Heidelberg Engineering, Germany) with the help of in-built caliber. Age, inter-gender, inter-eye and inter-ethnic differences in SFCTwere recorded and analyzed. Results: The average SFCT of right eye (RE) and left eye (LE) was 307.98 ± 74.64 μm and 312.63 ± 76.90 μm respectively, with average SFCT of 310.31 ± 75.70 μm for both eyes. SFCT of only the REwas selected for further calculation due to insignificant inter-eye difference of SFCT (p = 0.128). There was a significant negative correlation of SFCTwith age (r = −0.705, p = 0.01). A regression analysis showed thinning of SFCT by 3.50 ± 0.278 μm per year. In another context, SFCT of male and female was 305.49 ± 79.72 μm and 313.55 ± 70.76 μm respectively. However, there was no significant inter-gender difference (p = 0.51). Similarly, inter-ethnic variations of SFCTwas also statistically non -significant (p = 0.74). Conclusion: SFCT was negatively correlated with the age of participants, implying a decrease in choroidal thickness (CT) with an increase in age. Age can be considered as an important factor in the measurement of SFCT. Gender and ethnic groups did not have a significant role in the measurement and comparison of SFCT.
Elite capture, elite persistence and conflict in cross-scale linkages in the Mexican forest commons

Cross-scale governance has been posited as a requisite for sustainable resource management. However, recent work has emphasized that aside from the 'functionalities' or benefits of these arrangements, there are also 'dysfunctionalities' or failures (Benjamin et al. 2011). These failures often relate to the capture of these governance arrangements and their benefits by some groups at the expense of others, and to the ensuing conflicts related to these captures (see e.g. Adger et al., 2006). This paper, part of a dissertation project on cross-scale governance in community forestry, analyzes elite capture and conflict in two bottom-up (community-created) and two top-down (externally-created) cross-scale systems in community forestry in Durango, Mexico, focusing on how a combination of local institutions, power inequalities and political-economic and historical factors produce different forms of capture and resistance to it. Mexico, with a 'model' system of community forestry co-existing with a long history of authoritarian and clientelist forms of governance, provides an ideal setting to study these issues.
MEMORIZE TRAINING DATA EFFICIENTLY-REVI- SION

It has been observed (Zhang et al., 2017) that deep neural networks can memorize: they achieve 100% accuracy on training data. Recent theoretical results explained such behavior in highly overparametrized regimes, where the number of neurons in each layer is larger than the number of training samples. In this paper, we show that neural networks can be trained to memorize training data perfectly in a mildly overparametrized regime, where the number of parameters is just a constant factor more than the number of training samples, and the number of neurons is much smaller.
VHRM_A_221289 533..538

Peter P Toth Sephy Philip 3 Michael Hull Craig Granowitz 1CGH Medical Center, Sterling, IL, USA; 2Johns Hopkins University School of Medicine, Baltimore, MD, USA; 3Amarin Pharma Inc, Bedminster, NJ, USA; 4Optum, Eden Prairie, MN, USA Purpose: Real-world data may provide insight into relationships between high triglycerides (TG), a modifiable cardiovascular (CV) risk factor, and increased heart failure (HF) risk. Patients and methods: This retrospective administrative claims analysis included statintreated patients aged ≥45 years with diabetes and/or atherosclerotic CV disease enrolled in 2010 and followed for ≥6 months to March 2016. Patients with TG ≥150 mg/dL and a comparator cohort with TG <150 mg/dL and high-density lipoprotein cholesterol >40 mg/dL were included. A sub-analysis was conducted in patients with TG 200–499 mg/dL. Hazard ratios (HR) were calculated from multivariate analyses controlled for patient characteristics and comorbidities using Cox proportional hazard modeling. New diagnosis of HF required diagnosis in the followup period without prior evidence of HF. Results: Multivariate analyses revealed a 19% higher rate of new HF diagnosis in the TG ≥150 mg/dL cohort (HR=1.192; 95% confidence interval [CI]=1.134–1.252; P<0.001; n=24,043) and a 24% higher rate in the TG 200–499 mg/dL sub-cohort (HR=1.235; 95% CI=1.160–1.315; P<0.001; n=11,657), each versus the comparator cohort (n=30,218). Conclusion: In a real-world analysis of statin-treated patients with high CV risk, elevated and high TG were significant predictors of new HF diagnosis.
Assessing Major Adjustment Problems of Freshman Students in Jimma University

The primary purpose of this study was to explore the level and correlates of adjustment problems freshman students are facing in Jimma University. The study utilized three separately designed adjustment measures to collect data from 204 samples selected by multi-stage sampling procedure from the six colleges of the university. The data was analyzed by using both descriptive and inferential statistical methods. The result showed that half (50%) of freshman students in Jimma University experience social adjustment problems than educational and personalpsychological, which were found to be moderate. The study further revealed that female students are more prone to all forms of such adjustment difficulties, particularly of social adjustment difficulties (t (202) = -2.63, p = 0.05) as compared to their male counterparts. Finally, some implications are forwarded to further reinforce similar studies and intervention mechanisms are suggested.
DISCRIMINATOR BASED CORPUS GENERATION FOR GENERAL CODE SYNTHESIS

Current work on neural code synthesis consists of increasingly sophisticated architectures being trained on highly simplified domain-specific languages, using uniform sampling across program space of those languages for training. By comparison, program space for a C-like language is vast, and extremely sparsely populated in terms of ‘useful’ functionalities; this requires a far more intelligent approach to corpus generation for effective training. We use a genetic programming approach using an iteratively retrained discriminator to produce a population suitable as labelled training data for a neural code synthesis architecture. We demonstrate that use of a discriminator-based training corpus generator, trained using only unlabelled problem specifications in classic Programming-by-Example format, greatly improves network performance compared to current uniform sampling techniques.