Miracle-dz/UniFAR-FTUs huggingface dataset:
Total neoadjuvant chemotherapy with FLOT scheme in resectable adenocarcinoma of the gastro-oesophageal junction or gastric adenocarcinoma: impact on pathological complete response and safety

Background Gastric cancer is the fifth cause of cancer incidence worldwide. Multidisciplinary approaches that improve the survival are needed. Perioperative chemotherapies show improvement in pathological complete remission (pCR) and overall survival (OS), but less than 50% of the patients completed the chemotherapeutic regimen. The recent 5-fluorouracil, leucovorin, oxaliplatin, docetaxel-4 (FLOT4) study shows OS 50 months and pCR 16.6%, but only 46% of the patients completed pre- and postoperative treatment. This case series report evaluated pCR and safety in patients that received complete preoperative chemotherapeutic with FLOT. Methods Patients received eight cycles FLOT regimen before surgery. Each cycle comprised 50 mg/m2 docetaxel intravenous (iv) on day 1, 85 mg/m2 oxaliplatin iv on day 1, 200 mg/m2 leucovorin iv on day 1 and 2,600 mg/m2 5-fluorouracil iv in a 24-hour infusion on day 1, every 2 weeks. Results Fifty-nine patients were evaluated, 58 patients received preoperative cycles. Thirty-one patients received all eight cycles of preoperative therapy. 65.5% patients presented any major adverse event. Thirty-nine patients underwent surgery. Thirty-three biopsy reports were obtained. Six patients (18.2%) presented pCR, 13 patients (39.4%) had no lymph node involvement. OS was 21.32 months. Patients with histology of signet ring carcinoma cells had a shorter survival than other histologies. Conclusion Total neoadjuvant with FLOT chemotherapy presents an adequate safety profile, a similar pathologic regression rate, and a slightly higher rate of completing treatment to report in perioperative FLOT regimen studies. A prospective clinical study with suitable diagnostic, staging tools and an adequate follow-up may prove total neoadjuvant chemotherapy’s efficacy.
Effect of Tannin and Flavonoids of Different Sources on Ruminal Fermentation and Microbial Populations

Plant secondary metabolites (PSM|) are used as livestock feed additives instead of chemicals for their multiple effects on rumen microbiota, ammonia N production and fermentation end products. In this study we investigated the effect of two kinds of PSM used as feed additives and compare their effect to feeding whole alfalfa. Fifteen small tail Han rams were randomly allocated into five groups (n= 3/ group). CONT group (basal diet), HT group (basal diet supplemented with 2 g of Hydrolizable tannin), PF group (basal diet supplemented with 2g of Pueraria flavone) G3 group (basal diet +200g of Gannon 3 alfalfa) and G9 group (basal diet +200g of Gannon 9 alfalfa). For 30 days. At the end of the experiment rumen and serum samples were collected for SOD analysis, rumen pH, ammonia N concentration, total and proportional VFA and PCR quantification of total bacteria, F. succinogenase, methanogens and protozoa population. An in situ ruminal digestion kinetics experiment for soybean NDF was applied. Results showed that serum Superoxide dismutase enzyme (SOD), ruminal pH and ruminal ammonia N were not influenced by any of the treatments, but total volatile fatty acids (TVFA) and molar proportion of acetic acid were significantly reduced in HT group. Protozoa and methanogens were significantly increased in G9 and PF groups. Tannins and flavonoids of different of different sources and in different concentrations affect rumen ecosystem differently but, did not affect the serum SOD.
Response of chickpea to different growth parameters under conservation agriculture practices

A field experiment was conducted at Agriculture Research Station, Kalaburagi, University of Agricultural Sciences, Raichur, conducted during rabi 2016-17. To study the “Response of chickpea (Cicer arietinum L.) on different growth parameters under conservation agriculture practices”. The trial was laid out in Split plot design with four replications and six treatments and three main plots and two sub plots. Among all the treatments, Zero Tillage with residue retention significantly recorded higher plant height and total dry matter accumulation, grain and Stover yield, No of pods per plant and test weigh T. It is concluded that the among all treatments zero tillage with residue retention was found best combination for higher chickpea crop yields compared to other of treatments.
Kinetic Monte Carlo study on transient enhanced diffusion: posterior to amorphisation process

We report our theoretical investigations on the suppression of boron diffusion in the silicon substrate posterior to pre-amorphisation implant (PAI). We numerically investigated the defect-generating behaviour of silicon atoms and their subsequent effect on the transient enhanced diffusion (TED) of boron as a new species for PAI. Our kinetic Monte Carlo simulation revealed that Si–PAI produces more interstitials than the case of Ge–PAI, while Ge–PAI makes interstitial moves further up to the surface than the Si–PAI case during the annealing process, which results in the suppression of the boron TED.
Exploring the utility of the Chasing-rinciple: influence of drug-free SNEDDS composition on solubilization of carvedilol, cinnarizine and R3040 in aqueous suspension

This study assessed the in ﬂ uence of the composition of drug-free SNEDDS co-dosed with aqueous suspensions of carvedilol (CAR), cinnarizine (CIN) or R3040 on drug solubilization in a two-compartment in vitro lipolysis model. Correlation of drug log P or solubility in SNEDDS with drug solubilization during in vitro lipolysis in the presence of drug-free SNEDDS was assessed. SNEDDS with varying ratios of soybean oil:Maisine 35-1 (1:1, w / w ) and Kolliphor RH40, with ethanol at 10% ( w / w ) were used. SNEDDS were named F65, F55 and F20 (numbers refer to the percentage of lipids) and aqueous suspensions without drug-free SNEDDS (F0) were also analyzed. While the ranking order of drug solubilization was F65 ¼ F55 ¼ F20 4 F0 for CAR; F65 ¼ F55 4 F20 4 F0 for CIN and F65 ¼ F55 ¼ F20 4 F0 for R3040 - with higher CAR solubilization than for R3040 and CIN - the ranking of S eq of CAR, CIN and R3040 in SNEDDS was F65 o F55 o F20, F65 ¼ F55 4 F20 and F65 4 F55 4 F20, respectively. Therefore, the composition of SNEDDS in ﬂ uenced the solubilization of CIN, but not CAR and R3040. Furthermore, high S eq in SNEDDS did not re ﬂ ect high drug solubilization. As CAR (log P 3.8) showed higher solubilization than CIN (log P 5.8) and R3040 (log P 10.4), a correlation between drug log P and drug solubilization was observed.
PII: S0025-326X(99)00237-4

EVAN N. EDINGER à*, GINO V. LIMMON à , JAMALUDDIN JOMPA 2, §àà, WISNU WIDJATMOKO§§, JEFFREY M. HEIKOOPà± and MICHAEL J. RISKà§ Department of Earth Sciences, Laurentian University, Ramsey Lake Road, Sudbury, Ont. , Canada P3E 2C6 àSchool of Geography and Geology, McMaster University, Hamilton, Ont. , Canada L8S 4M1 §Biology Department, McMaster University, Hamilton, Ont. , Canada L8S 4K1 Faculty of Fisheries and Marine Science, Pattimura University, Ambon, Indonesia ààFaculty of Fisheries and Marine Science, Hasanuddin University, Ujung Pandang, Indonesia §§Faculty of Fisheries and Marine Science, Diponegoro University, Semarang, Indonesia ±Earth and Environmental Sciences Division, Geology and Geochemistry Group (EES-1), MS D462, Los Alamos National Laboratory, Los Alamos, NM 87545, USA
Method Development for Determination of Anthocyanidin Content in Bilberry (Vaccinium myrtillus L) Fruits

Abstract The optimal conditions for blueberry fruits extraction were chosen for better sample preparation. The biggest amount of anthocyanins was found in methanolic extracts. Ultrasonic extraction was performed for comparison with the maceration method. Ten minutes of ultrasonic extraction has shown the best recovery of anthocyanins in all analysed samples. The optimization of acid hydrolysis conditions was determined as well. At various times and concentrations of HCl, the hydrolysis of anthocyanins was conducted. Five major anthocyanidins (delphinidin, cyanidin, petunidin, peonidin, and malvidin) were estimated by high performance liquid chromatography (HPLC) in bilberry fruit extracts. A simple HPLC method has been developed for the analysis of anthocyanidins in bilberry extracts. The main steps of HPLC method validation were estimated, respectively.
Genetic Engineering in Viva Using Translocatable Drug-resistance Elements

A number of translocatable drug-resistance elements have recently been described which are able to insert themselves into a large number of different sites in prokaryotic genomes. These elements cause recognizable mutations when insertion occurs within a structural gene or an operon. Drug-resistance elements are also associated with other kinds of illegitimate recombination events, notably deletions and inversions. This paper summarizes uses to which these properties of translocatable drugresistance elements can be put in genetic manipulations of bacteria. Translocatable drug-resistance elements are useful in isolation of mutants (even where the mutant phenotype is not easily scored), in the construction of strains and other genetic manipulations (even when selection is difficult or impossible), in localized mutagenesis, in chromosomal mapping, in construction of Hfr strains with known origin and direction of chromosome transfer, in complementation tests, in construction of new F’ plasmids, in construction of new specialized transducing phages, in isolation of deletions with one or both endpoints specified, in construction of gene and operon fusions, and in the seiection and maintenance of chromosomal duplications. Experiments are described which illustrate many of these techniques.
ENHANCED BIOLOGICAL PHOSPHORUS REMOVAL: MODELLING AND EXPERIMENTAL DESIGN GESTIMULEERDE BIOLOGISCHE FOSFAATVERWIJDERING: MODELBOUW EN EXPERIMENTEEL ONTWERP

PolyHydroxyAlkanoates (PHA) and Poly-β-HydroxyButyrate (PHB) in particular has become a compound which is routinely investigated in wastewater research. The PHB analysis method is only recently applied to activated sludge samples where PHA contents might be relatively low. This urges the need to investigate the reproducibility of the gas chromatographic method for PHB analysis. This was evaluated in a Round-Robin test in 5 European laboratories with samples from lab-scale and full-scale enhanced biological phosphorus removal systems. The basic method was direct solvent extraction of lyophilised cells, depolymerisation (hydrolysis) of the polymer and alkylation of the alkanoates. All steps take place in one tube with the necessary incubation time generally being 2 hours. The concentration of the (propyl)ester is then analysed by gas chromatography. Each lab used slightly modified methods. It was observed that the use of an internal standard improved the reproducibility of the method, that using dichloro(m)ethane as solvent instead of chloroform improves the GC analysis and that shaking the reaction tubes during heating improves the esterification reaction. It was shown that the standard deviation of measurements in each lab and the reproducibility between the labs was very good. Experimental results obtained by different laboratories using this analysis method can be compared. Sludge samples with PHB contents varying between 0.3 and 22.5 mg PHB/mg sludge were analysed. The gas chromatographic method allows for PHV, PH2MB and PH2MV analysis as well. The gas chromatographic analysis of PHA is important for kinetic modelling of EBPR processes. Moreover, with the publication of the Activated Sludge Model No3 and the general acceptance that storage polymers are of prime importance for non polyphosphate accumulating organisms as well, analysis of internal storage components becomes a prerequisite for modelling the activated sludge processes.
Low intensity Extra Corporeal Shock Wave Therapy in Patients with Erectile Dysfunction: Our experience in ACKU

Introduction: Oral 5-phosphodiesterase inhibitors (PDE5-I) is the main therapeutical options in erectile dysfunction (ED). It shows good results, but non-responders lack other effective options and its effect is also not long lasting. Since last few years, low-intensity extracorporeal shockwave therapy (Li-ESWT) in the corpora cavernosa showing promising results. This article presents our early experiences in Advanced Center of Kidney disease and Urology (ACKU) with the aim to evaluate clinical efficacy of Li-ESWT. Materials and methods: Thirty four patients with ED were prospectively included in the study during the period of January 2018 to Jun 2019.Treatment was performed using the PiezoWave2 (Richard Wolf, Germany) device with a linear probe. Treatment protocol included a weekly session for four weeks. Each session delivered 2000 shocks on the perineum plus 4000 shocks on dorsum penis with an energy flux density (EFD) of 0.160 mJ/mm2. Every patient has been re-evaluated 1.5 and 3 months after the last session. Pre- and post-procedure International Index Erectile Function – Erectile function domain (IIEF-EF) score, Erection Hardness Score (EHS) and Global Assessment Questionnaire-Question 1 (GAQ-Q1) answers were obtained. Results: Mean age of the study population was 39.4 (±12.9) years, 35.29% diabetic, 20.59% with hypertension and 55.85% smokers. Mean baseline IIEF-EF was 14.6, at 6 week post LiSWT was 16.4 (p >0.05) and at 3 months post LiSWT was 19.2 (p < 0.05). EHS was significantly improved at 3 month in comparison to baseline (p<0.05). 20.59% patients answered positively to GAQ-Q1 at 6 week and 61.76% at 3 months. IIEF-EF score change of >5 and increase of EHS >2 were observed in 62.88% and 70.59% study subjects respectively. Conclusions: Li-ESWT is a safe, harmless and repeatable treatment tool for ED with good outcomes reported. Bangladesh Journal of Urology, Vol. 23, No. 2, July 2020 p.176-180
Chemical Composition of Aerosols from Kerosene Heaters Burning Jet Fuels

During the Persian Gulf conflict, some of the U.S. military personnel were diagnosed with a "mystery illness" or "Gulf War Syndrome. " Environmental exposure included combustion products from unvented heaters in tents and may have contributed to the observed health effects. In our previous study, gases, including NO, CO, and SO 2 emitted from various heaters burning different fuels within an Army tent, were measured and analyzed. Aerosols from the heaters were characterized physically and chemically. This paper discusses chemical analyses of particulate emissions from the same heaters and fuels as presented in the previous study. The results were compared with gas analyses under the same conditions. In the elemental study, each heater and fuel produced large amounts of sulfur. Other elements, such as silica, aluminum, iron, etc., came from the ambient air. A few traces of lead were found in these analyses, but the source of the lead was unknown. Elemental and organic carbons were also detected. The rate of total carbon emission depended on heater and fuel types. The ion chromatography analysis revealed high emission rates of sulfate, and the results agreed with the elemental study. In addition to the SO = 4 , a high ammonium emission rate was detected. Compared to the SO = 4 and NH + 4 , the nitrate emission rate was relatively low. Considering all of the data, it appears that the carbon, SO = 4 , and NH + 4 from the fuels contributed to the pollutant in the tent.
ADBI Working Paper Series NAÏVE OR SOPHISTICATED? INFORMATION DISCLOSURE AND INVESTMENT DECISIONS IN PEER-TO-PEER LENDING

Despite the explosive growth of peer-to-peer lending in the People’s Republic of China (PRC), information asymmetry remains a critical issue and is likely to be amplified in such an evolving credit market compared to a traditional credit market. This paper studies how investors screen the nonstandard, voluntary, and often unverifiable information disclosed by borrowers in making their investment decisions. Using data from the Renrendai P2P platform, one of the leading lending platforms in the PRC, we find that an additional item of disclosure increases the funding probability by 23.6%. The impact is even more remarkable for borrowers with a lower credit rating. However, investment in loan listings with more disclosures turns out to be riskier. An additional item of disclosure is accompanied by an incremental default probability of 11.7%. The puzzle that lenders remain attracted by such loan listings is explained by the higher profitability offered by the borrowers. Further investigation shows that investors can infer the real risk of borrowers marked by the disclosure.
New investigation in regime transition from bubbling to turbulent fluidization

The regime transition velocity from bubbling to turbulent fluidization was investigated in a 0.267 m diameter fluidized bed with FCC particles. Different transition velocities and processes are found from the measurements of differential pressure fluctuations and local solids concentration. The measurements of differential pressure fluctuations shows a relatively quicker global regime transition, while the local regime transition obtained from the local solids concentration presents a more gradual process marked by two transition velocities. These transition velocities increase with initial static bed height. For the same initial static bed height, increasing the spacing between two pressure taps leads to lower pressure fluctuations and the appearance of two transition velocities. On a etudie la vitesse de transition de regime entre la fluidisation bullante et turbulente dans un lit fluidise de 0,267 m de diametre garni de particules de FCC. Differentes vitesses de transition associees a des processus differents ont ete obtenues a partir des mesures de fluctuations de pression differentielle et de concentration des solides. Les mesures de fluctuations de pression differentielle montrent la presence d'une transition de regime globale plus rapide, tandis que la transition de regime local obtenue a partir de la concentration de solides locale presente un processus graduel marque par deux vitesses de transition. Ces vitesses de transition augmentent avec la hauteur de lit statique initiale. Pour la meme hauteur de lit statique initiale, le fait d'augmenter l'espacement entre les deux prises de pression entraine des fluctuations de pression plus faibles et l'apparence de deux vitesses de transition.
Added value of geophysics-based soil mapping in agro-ecosystem simulations

Abstract. There is an increased demand for quantitative high-resolution soil maps that enable within-field management. Commonly available soil maps are generally not suited for this purpose, but digital soil mapping and geophysical methods in particular allow soil information to be obtained with an unprecedented level of detail. However, it is often difficult to quantify the added value of such high-resolution soil information for agricultural management and agro-ecosystem modelling. In this study, a detailed geophysics-based soil map was compared to two commonly available general-purpose soil maps. In particular, the three maps were used as input for crop growth models to simulate leaf area index (LAI) of five crops for an area of ∼ 1 km2. The simulated development of LAI for the five crops was evaluated using LAI obtained from multispectral satellite images. Overall, it was found that the geophysics-based soil map provided better LAI predictions than the two general-purpose soil maps in terms of correlation coefficient R2, model efficiency (ME), and root mean square error (RMSE). Improved performance was most apparent in the case of prolonged periods of drought and was strongly related to the combination of soil characteristics and crop type.
ABOVE- AND BELOW-GROUND NUTRIENT TISSUE CONCENTRATION AND LEAF PIGMENT CHANGES IN PATAGONIAN WOODY SEEDLINGS GROWN UNDER LIGHT AND SOIL MOISTURE GRADIENTS

To understand the ecophysiology of natural regeneration above- and below-ground nutrient tissue concentration and leaf pigment changes in Nothofagus pumilio (lenga) seedlings grown in three light intensities (4%, 26% and 64% of natural irradiance) and two soil moisture levels (40–60% and 80–100% soil capacity) under greenhouse controlled conditions were evaluated. Carbon (C), nitrogen (N), phosphorus (P), magnesium (Mg), potassium (K), calcium (Ca) and pigment (chlorophylls and carotenoids) were measured on seedlings. Carbon, N, Mg, K and Ca increased in low light intensity and soil moisture treatments, while P decreased. Nutrients were higher in above- than in below-ground biomass. Chlorophylls were lower in high light treatments, while carotenoids increased their content. All pigments were greater in low soil moisture treatments. These changes are closely related to their photosynthetic plasticity and biomass compartmentalization. Plants growing in high light were more efficient to produce the same amount of plant biomass.
THE APPROACH TO SUICIDE: REVIEW OF THE AUTONOMOUS STRATEGIES FOR THEIR INTERVENTION

Background: Suicide is one of the most pressing problems worldwide, one of the main social challenges. In Spain, suicide mortality is the leading cause of external death, maintaining the suicide rate relatively stable or even increasing in some age groups in a context in which the mortality of the population due to external causes follows a decreasing trend. Despite the alarming figures, in Spain there is no National Plan for Suicide Prevention, being the main initiatives to address this problem of regional or local court. The objective of the present study was to present the state of the matter regarding the approach to suicide in Spain. Methods: A review was carried out in the main search engines, both general (Google) and specialized (Psicodoc, Psicyinfo), introducing several key words. The results were filtered excluding local court initiatives, incorporating interventions at the community level. Their content was analyzed and the foundations of each strategy were presented. Results: A total of 22 interventions were found in 16 autonomous communities (all except Murcia). Conclusions: We can conclude the serious lack of treatment related to this problem. For the most part, strategies for working suicide are incorporated into Mental Health plans. The need to continue working on the design of effective and comprehensive interventions, focused on prevention that address the phenomenon from a multidisciplinary approach, specifically focused on the problem, is evident.