Miracle-dz/UniFAR-FTUs huggingface dataset:
Did taller people live longer? Influence of height on life span in rural Spain, 1835-2019

: This article analyses the relationship between male height and age at death among adults born between 1835 and 1939 in fourteen villages in north-east Spain. A total of 1,488 conscripts who died between 1868 and 2019 have been included in the analysis. The height data have been obtained from conscriptions for military service; demographic and socioeconomic data of the deceased were obtained from parish archives and censuses. The data were linked according to nominative criteria using family reconstitution methods. The results suggest that there has been a positive relationship between height and life span in the long-term. For the birth cohorts of 1835-1869, conscripts with a height of 170 cm or more lived on average 7.6 years longer than individuals measuring less than 160 cm. This biological difference disappeared for the birth cohort of 1900-1939 due to a progressive improvement in health and nutrition conditions, benefiting especially the short conscripts.
A Retrospective Analysis of Human Parainfluenza Virus in the Pediatric Population

Context: Human Parainfluenza Viruses (HPIVs) are among the most common acute respiratory infections in children and contribute significantly to hospitalizations and emergency room visits in the pediatric population. Differences in clinical presentation and sequelae of the four HPIV serotypes have not been thoroughly characterized. This study describes the clinical symptoms, disease severity, and care demands associated with each of the viral serotypes, which may aid in decision making for the most appropriate available treatment modalities for future pediatric patients and improve quality of care. Objectives: course of infection and require escalation of care to the Pediatric Intensive Care Unit (PICU). Methods: This single-center, retrospective, observational study reviewed 40 pediatric patients admitted to Spartanburg Regional Healthcare System (SRHS) with parainfluenza virus during a 15-month period. Inclusion criteria consisted of all patients less than 18 years of age admitted to the general pediatric ward or the PICU with a diagnosis of parainfluenza types 1-4 confirmed on a polymerase chain reaction-based test called FilmArray. Demographic and clinical data were collected and analyzed. Results: The collected data found 75% of patients across all serotypes displayed nonspecific upper respiratory symptoms, while only 35% of patients (primarily HPIV-1 and 2 cases), manifested traditional croup symptoms. The most frequently diagnosed serotype was HPIV-3 and these patients experienced higher rates of bronchiolitis, pneumonia and Upper Respiratory Infection (URI) symptoms compared to other serotypes. While no statistical significance was observed in our small population, serotypes 1 and 4 necessitated greater care demands; with HPIV-1 resulting in the most PICU admissions (50%) and HPIV-4 patients averaging the longest length of stay and requiring the most supplemental oxygen. Conclusion: This single-center, retrospective, observational study suggests that understanding the differences in symptomatology and severity of each serotype may proactively aid in the proper treatment and care of parainfluenza virus in the pediatric population. Further investigative studies with an increased sample size, multiple sites, and longer duration would be beneficial to support the data and further delineate preemptive actions when caring for the pediatric population with HPIV.
Atmospheric oxidation of α,β-unsaturated ketones: kinetics and mechanism of the OH radical reaction

Abstract. The OH radical initiated oxidation of 3-methyl-3-penten-2-one and 4-methyl-3-penten-2-one was investigated in two atmospheric simulation chambers at 298 ± 3 K and 990 ± 15 mbar using long-path FTIR spectroscopy. The rate coefficients of the reactions of 3-methyl-3-penten-2-one and 4-methyl-3-penten-2-one with OH radicals were determined to be (6.5 ± 1.2) × 10−11 cm3 molecule−1 s−1 and (8.1 ± 1.3) × 10−11 cm3 molecule−1 s−1, respectively. To enlarge the kinetics data pool the rate coefficients of the target species with Cl atoms were determined to be (2.8 ± 0.4) × 10−10 cm3 molecule−1 s−1 and (3.1 ± 0.4) × 10−10 cm3 molecule−1 s−1, respectively. The mechanistic investigation of the OH initiated oxidation focuses on the RO2 + NO reaction. The quantified products were acetoin, acetaldehyde, biacetyl, CO2 and peroxyacetyl nitrate (PAN) for the reaction of 3-methyl-3-penten-2-one with OH radicals and acetone, methyl glyoxal, 2-hydroxy-2-methylpropanal, CO2 and peroxyacetyl nitrate (PAN) for the reaction of 4-methyl-3-penten-2-one with OH, respectively. Based on the calculated product yields an upper limit of 0.15 was determined for the overall organic nitrates (RONO2) yield derived from the OH reaction of 4-methyl-3-penten-2-one. By contrast, no RONO2 formation was observed for the OH reaction of 3-methyl-3-penten-2-one. Additionally, a simple model is presented to correct product yields for secondary processes.
Class Project 2: Market states prediction

—Trends in daily stock price movement were used to classify individual days into similar clusters using the Louvain algorithm. The result was a time series representing the daily market state. Three different supervised time series multivariate classiﬁcation models, namely LSTM, random forest and TCN, were then used to attempt to predict the next day’s market state using the previous days as features. Performance of the models were low, though this was likely due to a non-deterministic classiﬁcation process. Nonetheless, preliminary results show that the models consistently performed better than a Markovian process of ﬁrst order, indicating some longer-term memory of the markets.
Evaluation of antioxidant potential of pigments extracted from Bacillus spp. and Halomonas spp. isolated from mangrove rhizosphere

The present study aimed to isolate different pigment-producing bacteria from the mangrove rhizosphere habitat and to extract their pigments for evaluating their antioxidant and sun-protective properties. Three pigment-producing bacterial cultures were isolated from soil samples and were identified by morphological analysis and 16S rDNA sequencing. The pigments were isolated by the solvent extraction method and named as MZ (Pink), Orange, and Yellow. They were characterized by Fourier Transform Infrared (FTIR) and UV-Vis spectroscopy. The sun protection factor (SPF) values of these pigments were then determined using the Mansur equation. The total polyphenol content was estimated by the Folin-Ciocâlteu method, and the antioxidant activity of the pigments was determined using DPPH (2,2-diphenyl-1-picrylhydrazyl), FRAP (ferric reducing antioxidant power), and ABTS (2,2-azinobis-3-ethyl-enzothiazoline-6-sulfonic acid) assays. The in vitro antioxidant potential of the pigments in the presence of oxidative stress (H2O2) was confirmed in the mouse macrophage cell line RAW264.7 by using the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) assay. The pigment-producing bacterial isolates were identified as Bacillus infantis (MZ), Halomonas spp. (Orange), and Bacillus spp. (Yellow). The pigments were found to be carotenoid in nature, and the SPF values were in the range of 3.99 to 5.22. All three pigments had high polyphenol content (22 to 48 μg tannic acid equivalent) and showed significant antioxidant properties in both chemical and cell line-based studies. The results of this study indicate that these pigments have the potential to be used as an antioxidant agent and can be further developed as a pharmaceutical compound.
Quality and usability of clinical assessments of static standing and sitting posture: A systematic review.

BACKGROUND A validated method to assess sitting and standing posture in a clinical setting is needed to guide diagnosis, treatment and evaluation of these postures. At present, no systematic overview of assessment methods, their clinimetric properties, and usability is available. OBJECTIVE The objective of this study was to provide such an overview and to interpret the results for clinical practice. METHODS A systematic literature review was performed according to international guidelines. Two independent reviewers assessed risk of bias, clinimetric values of the assessment methods, and their usability. Quality of evidence and strength of recommendations were determined according to the Grading of Recommendations Assessment, Development and Evaluation working group (GRADE). RESULTS Out of 27,680 records, 41 eligible studies were included. Thirty-two assessment instruments were identified, clustered into five categories. The methodological quality of 27 (66%) of the articles was moderate to good. Reliability was most frequently studied. Little information was found about validity and none about responsiveness. CONCLUSIONS Based on a moderate level of evidence, a tentative recommendation can be made to use a direct visual observation method with global posture recorded by a trained observer applying a rating scale.
Variation in Tree Growth Characteristics, Pilodyn Penetration, and Stress-wave Velocity in 65 Families of Acacia mangium Trees Planted in Indonesia

1) Growth characteristics [stem diameter (D), tree height (H)] and wood properties [Pilodyn penetration (P) and stress-wave velocity (SWV)] were measured for 65 families of 6-year-old Acacia mangium trees planted in Indonesia, in order to characterize their variation in D, H, P, and SWV. Therefore, the correlations between the measured characteristics were also determined, and their significant differences observed. Furthermore, their low to moderate values of narrow-sense heritability was obtained, and the results indicated the characteristics to be genetically controlled in A. mangium. In addition, highly significant positive correlations were observed among the growth characteristics, suggesting a close relationship, while there was no significant association between the growth characteristics and P, as well as SWV, indicating their independent. Therefore, these results demonstrate a potential for the improvement of both growth and wood properties of A. mangium trees, using the appropriate breeding programs. In addition, 18 families showed good performance in D and SWV, signifying their positive prospect of being considered as plus trees for the next generation breeding cycles.
Transthyretin Gene Mutation Associated with Familial Carpal Tunnel Syndrome in Sample of Iraqi Patients

Background: Carpal tunnel syndrome (CTS) is the most common entrapment neuropathy in upper limbs. It affects women more frequently than men. CTS can be caused by many different systemic diseases and local mechanical conditions and it had signs and symptoms due to compression of median nerve at the carpal tunnel in wrist. Objective: The present study aims to study whether Transthyretin (TTR) gene polymorphisms have association with the development of FCTS. Methods: Sixty-four patients suffering from CTS were enrolled in this controlled cross sectional study. For all, nerve conduction study was performed to prove the diagnosis of CTS and to classify its severity. The mean age of all patients was 44.9±7.8 years, 89.1 % were female, 37.5 % had mild type CTS and 40.7 % had right side CTS. 3 mL of peripheral blood was collected from all patients which is a labeled (EDTA) tube at -20 C° for DNA extraction to identify a particular SNP (rs28933979; 148G/A; V50M) that locates at position chr18:31592974 on the exon-2 region which is reported to be associated to the Carpal Tunnel Syndrome. Exon-2 of TTR gene was amplified using the PCR technique and subjected to be tested for presence of SNP by Restriction Fragment Length Polymorphism (RFLP) assay. Results and Conclusion: According to genetic variation, the study cannot discover any TTR gene polymorphism that back to FCTS.
Insights from Local Network Structures and Localized Diffusion on the Ease of Lithium Ion Transport in Two Mixed Glass-Former Systems

The conductivity enhancement observed in the two glass systems A (40Li2O–(60–x)P2O5–xGeO2) and B (40Li2O–10B2O3–(50–x)P2O5–xGeO2) as the germanate content is increased from 0 to 25 mol % confirms the positive mixed glass-former effect (MGFE) in these systems. In this study, we further employ state-of-the-art NMR techniques along with Raman spectroscopy to probe the local network structures. We use the MIGRATION concept to model the experimental conductivity and permittivity spectra obtained from impedance spectroscopy to understand the scaling features of the spectra and to calculate the value of the spatial extent of the localized diffusion of the lithium ion. As x increases from 0 to 25 mol %, for system A, a continuous increase of the POGe cross-linkages as well as a continuous and strong modification of the phosphate network is observed. In system B, deeper analysis of the 31P magic-angle spinning NMR experiments done using 2D 11B/11B homonuclear and 11B/31P heteronuclear NMR is used to determine the .
Perception and Decision Making: A Multi-Technique Analysis of Campaign Posters in the 2019 Bogotá Mayoral Election

Campaign posters are semiotic-discursive resources that form multimodal units of meaning. In political communication, voters’ decision making is affected not only by the verbal message, but also by nonverbal indications or physical features (visual attributes) of the candidates. This study analyzed the relationship between visual communication and citizens’ voting decisions in a political campaign in Colombia. An analysis of campaign posters in the 2019 Bogotá mayoral elections was designed using a multi-technique methodology. First, two eye-tracking experiments were conducted to assess attention patterns. Then, a series of surveys measured emotions in slogans. It was concluded that, in the Colombian scene, visual elements related to candidates’ physical attributes have a small influence over voters’ decision making. This finding contradicts the results of studies carried out in different contexts, namely in Europe and the United States.
Booster and anergic effects of the Covishield vaccine among healthcare workers in South India

Covishield (same as ChAdOx1) vaccine was rolled out in January 2021 against SARS-CoV2 in India. Although studies show good efficacy after two doses, there is limited data on the fate of the elicited antibody responses over time in groups with or without prior exposure to SARS-CoV2. Therefore, in this study we proposed to test naive or previously exposed healthcare workers (HCWs) longitudinally after both doses for anti-SARS-CoV2 spike antibody (ASSA) levels. Serum samples were collected from 205 HCWs at days 14 and 28 after first dose, and at days 14, 28 and 3-months after second dose. ASSA levels were quantitated by ECLIA method. Non-responder rate was 17% (35 of 205) on day 14 and 2% (5 of 205) on day 28 after the first dose. After the second dose, the responder rate was 100%. Non-responder rate was significantly higher among males (p<0.00001) and senior citizens (p=0.008). The second dose boosted a 27-fold increase in the COVID-19 naive (CN) group, but caused a 1.5-fold decline in the previously exposed groups. By three months, the antibody levels declined 3-4-folds in all the groups. In spite of high antibody levels (GM-1007 U per ml) after the second dose, 14% developed mild breakthrough infections (BTI). The booster effect was significantly higher when given 10-14 weeks later. The responder rate for Covishield was 98% after first dose and 100% after second dose. The vaccine elicited a prime-boost effect in CN HCWs and a boost-anergy effect in the previously exposed HCWs. ASSA levels began to decline proportionately by three months.
Title : Ccr 6 deficiency attenuates spontaneous chronic colitis in Winnie

The immunomodulatory behaviour of the CCR6/CCL20 axis on multi -system pathophysiology and molecular signalling was investigated at two clinically significant time points, using a Ccr6 deficient mouse model of spontaneous colitis. Four groups of mice, (C57BL/6J, Ccr6-/of C57BL/6J, Winnie x Ccr6 -/and Winnie) were utilized and (I) colonic clinical parameters (2) histology of colon, spleen, kidney and liver (3) T and B lymphocyte distribution in the spleen and MLN by flowcytometry (5) colonic CCL20, PI3K and phosphorylated Akt expression by immunohistochemistry and (6) colonic cytokine expression by RT-PCR were evaluated. CCR6 influenced upregulation of inflammation in the spleen, liver and gut while renal histology remained unaffected. Marked focal lobular inflammation with reactive nuclear features were observed in hepatocytes and a significant neutrophil infiltration in red pulp with extra medullary hemopoiesis in the spleen existed in Winnie. These changes were considerably reduced in Winnie x Ccr6-/with elevated goblet cell numbers and mucus production in the colonic epithelium. Results indicate that Ccr6deficiency in the colitis model contributes towards resolution of disease. Our findings demonstrate an intricate networking role for CCR6 in immune activation, which is downregulated by Ccr6 deficiency, and could provide newer clinical therapies in colitis. Preprints (www.preprints.org) | NOT PEER-REVIEWED | Posted: 18 December 2019 doi:10.20944/preprints201912.0238. v1 © 2019 by the author(s). Distributed under a Creative Commons CC BY license.
Excitation of Polycyclic Aromatic Hydrocarbon Emission: Dependence on Size Distribution, Ionization, and Starlight Spectrum and Intensity

Using physical models, we study the sensitivity of polycyclic aromatic hydrocarbon (PAH) emission spectra to the character of the illuminating starlight, to the PAH size distribution, and to the PAH charge distribution. The starlight models considered range from the emission from a 3 Myr old starburst, rich in far-ultraviolet (FUV) radiation, to the FUV-poor spectrum of the very old population of the M31 bulge. A wide range of starlight intensities is considered. The effects of reddening in dusty clouds are investigated for different starlight spectra. For a fixed PAH abundance parameter q PAH (the fraction of the total dust mass in PAHs with <103 C atoms), the fraction of the infrared power appearing in the PAH emission features can vary by a factor of two as the starlight spectrum varies from FUV-poor (M31 bulge) to FUV-rich (young starburst). We show how q PAH can be measured from the strength of the 7.7 μm emission. The fractional power in the 17 μm feature can be suppressed by high starlight intensities.
The Absence of Mutations in the Exon 2 KRAS Gene in Several Ethnic Groups in North Sumatra May Not the Main Factor for Lung Cancer

Background: Rat Sarcoma (RAS) protein encoded Guanosine Triphosphate (GTP-ase) activity, known as a switch of cell proliferation. The mutation of this protein alters the early stage of carcinogenesis and along with the interaction with other oncogene drivers and environmental factors affect the clinical characteristics and prognosis in cancer patients, particularly lung cancer. Objective: This study aims to determine the Kristen Rat Sarcoma (KRAS) mutation in lung cancer patients in North Sumatera and evaluate factors that might contribute in the development of lung cancer in the absence of KRAS mutation. Methods: This was a retrospective cohort study enrolled 44 subjects age > 18 year with the diagnosis of lung cancer. Histopathology preparation was obtained from surgery, bronchoscopy, and percutaneus needle biopsy then formed as paraffin-block. KRAS mutation was analyzed using Polymerase Chain Reaction (PCR) method with specific primer of exon 2 for evaluating the expression of RAS protein then continued with Sanger Sequencing Method at 12th and 13th codon. Results: The majority of subjects were male, age > 40 years old, bataknese, heavy smoker, with Adenocarcinoma. Almost all the subjects showed the expression of exon 2 of RAS protein in PCR examinations. However, Sequencing analysis using Bioedit Software, BLASTs and Finch T showed GGT GGC as protein base 219-224 which represented 12th and 13th Codon 12 and 13. The results interpreted there was no mutations of exon 2 of KRAS in North Sumatera Population. Conclusion: The absence of KRAS mutation in exon 2 in several ethnics in North Sumatera populations was not the main factors of lung cancer.
Crop Production and Phosphorus Legacy with Long-Term Phosphorus- and Nitrogen-Based Swine Manure Applications under Corn-Soybean Rotation

The traditional manure management strategy, based on crop N needs, results in accumulation of phosphorus (P) in soil due to the imbalance of N/P ratio between crop requirement and manure supply. This study was conducted from 2004 to 2013 to evaluate the effects of P-based liquid and solid swine manure (LMP and SMP, for P-based liquid and solid swine manure, respectively) application, in comparison with N-based application (LMN and SMN, for N-based liquid and solid swine manure, respectively), on crop yield and soil residual P under corn (Zea mays L.)–soybean (Glycine max L.) rotation in a Brookston clay loam soil of the Lake Erie basin, ON, Canada. Chemical fertilizer P (CFP) and non-P treatments were included as controls (CK). For liquid manure treatments, corn yield for LMN showed a lower annual corn yield (7.82 Mg ha−1) than LMP (9.36 Mg ha−1), and their differences were even statistically significant at p < 0.05 in some cropping years. The annual corn yield of LMP was also higher than those of SMP (7.45 Mg ha−1) and SMN (7.41 Mg ha−1), even the CFP (8.61 Mg ha−1), although the corresponding yield differences were not significant (p < 0.05) in some cropping years. For soybean, the plots with P application produced an average of 0.98 Mg ha−1 greater annual yields than CK. No significant differences were found between CFP and manure treatments. The annual corn yield of SMN was close to that of the CK (7.19 Mg ha−1). The grain P removal (GPR) of SMN (18.6 kg ha−1) for soybean was significantly higher than that of the other treatments. The above-ground-P uptake (AGPU) in SMN, for both corn and soybean, was significantly higher than that of the other five treatments. The soil test P (STP) presented clear stratification, concentrating in the top 30 cm soil depth after 10 years of application. The contents of STP with LMN and SMN increased from 7.1 mg P kg−1 to 12.4 and 45.5 mg P kg−1, respectively. The sum of STP mass (0–30 cm) with LMP (31.6 kg ha−1) was largely identical to that with CFP (30.1 kg ha−1); however, with SMN (173.7 kg ha−1), it was significantly higher than the rest of the treatments. Manure P source availability coefficients were averaged at 1.06 and 1.07 for LMP and SMP, respectively. The addition of phosphorus-based liquid or solid swine manure can overcome the drawback of traditional N-based applications by potentially reducing the adverse impact on water quality while sustaining crop agronomic production.