Miracle-dz/UniFAR-FTUs huggingface dataset:
A Case-Control Study of Real-Life Experience with Ceftolozane-Tazobactam in Patients with Hematologic Malignancy and Pseudomonas aeruginosa Infection

We present our experience in patients with hematologic malignancy and Pseudomonas aeruginosa infection treated with ceftolozane-tazobactam. We performed a single-center case-control study comparing patients with hematologic malignancy and P. aeruginosa infection treated with ceftolozane-tazobactam (study group) with similar patients not treated with ceftolozane-tazobactam (control group) to assess safety and efficacy. ABSTRACT We present our experience in patients with hematologic malignancy and Pseudomonas aeruginosa infection treated with ceftolozane-tazobactam. We performed a single-center case-control study comparing patients with hematologic malignancy and P. aeruginosa infection treated with ceftolozane-tazobactam (study group) with similar patients not treated with ceftolozane-tazobactam (control group) to assess safety and efficacy. Nineteen cases and 38 controls were analyzed. Cases were younger (45.6 years versus 57.6 years; P = 0.012) and less frequently had bacteremia (52.6% versus 86.8%; P = 0.008). They also had worse Multinational Association for Supportive Care in Cancer (MASCC) scores (10.2 versus 16.1; P = 0.0001), more hospital-acquired infections (78.9% versus 47.4%; P = 0.013), and more extremely drug-resistant (XDR) P. aeruginosa infections (47.4% versus 21.1%; P = 0.015). Cases received a median of 14 days (7 to 18 days) of ceftolozane-tazobactam (monotherapy in 11 cases [57.9.6%]). Ceftolozane-tazobactam was mostly used as targeted therapy (16 cases; 84.2%) because of resistance (9 cases; 47.4%), failure (4 cases; 21.1%), and toxicity (3 cases; 15.8%). Ten cases had bacteremia (52.6%). The sources were pneumonia (26.3%), catheter-related bacteremia (21.1%), primary bacteremia (21.1%), and perianal/genital (15.7%), urinary (10.5%), and skin/soft tissue (5.3%) infection. No toxicity was attributed to ceftolozane-tazobactam. More than 60% had neutropenia, and 15.8% fulfilled the criteria for sepsis. There were no significant differences in clinical cure at day 14 (89.5% versus 71.1%; P = 0.183) or recurrence (15.8% versus 10.5%; P = 0.675). Thirty-day mortality was lower among cases (5.3% versus 28.9%; P = 0.045). Ceftolozane-tazobactam was well tolerated and at least as effective as other alternatives for P. aeruginosa infection in patients with hematologic malignancy, including neutropenic patients with sepsis caused by XDR strains.
Characterizing the dynamical phase diagram of the Dicke model via classical and quantum probes

R. J. Lewis-Swan ,1,2 S. R. Muleady ,3,4,* D. Barberena ,3,4,* J. J. Bollinger ,5 and A. M. Rey 3,4 1Homer L. Dodge Department of Physics and Astronomy, The University of Oklahoma, Norman, Oklahoma 73019, USA 2Center for Quantum Research and Technology, The University of Oklahoma, Norman, Oklahoma 73019, USA 3JILA, NIST, Department of Physics, University of Colorado, Boulder, Colorado 80309, USA 4Center for Theory of Quantum Matter, University of Colorado, Boulder, Colorado 80309, USA 5National Institute of Standards and Technology, Boulder, Colorado 80305, USA
Predicting Onset of Combustion Instability in Gas Turbines Using Fiber Optic Sensors

A data driven method based on cross-entropy derived from symbolic time series analysis of the chemiluminescence and pressure variations has recently been found to be robust and computationally efficient among existing methods for predicting instability. In this article, we report the development and testing of compact and field-deployable optical fiber-based modules for sensing chemiluminescence and pressure variations in the combustor. The time-series data obtained from the above sensor modules are used to deduce the D-Markov cross-entropy for different protocols corresponding to typical combustor operation conditions. Such cross-entropy data is compared with similar data obtained from standard high speed camera and PZT-based pressure sensors. It is found that the fiber optic sensor modules compare favorably with the conventional sensors thereby providing an exciting new pathway for field-deployable solutions to monitor the onset of thermo-acoustic instability in combustors.
Soil nutrients and dispersal limitation shape compositional variation in secondary tropical forests across multiple scales

Soil resource partitioning and dispersal limitation have been shown to shape the tree community structure of mature tropical forests, but are poorly studied in the context of forest succession. We examined the relative contributions of both ecological processes to the variation in the species composition of young tropical secondary forests at different spatial scales, and if the relative importance of these two ecological processes changed during succession. At the species level, we examined if the association between species abundances and soil fertility differed between early and late successional species and/or changed over the course of succession. We used vegetation and soil data from 47 secondary forest sites with two plots each in a tropical agricultural landscape. A distance‐based redundancy analysis and variation partitioning were employed to examine the relative importance of spatial distance (proxy for dispersal limitation) and heterogeneity in soil nutrients (proxy for soil nutrient partitioning) at the landscape scale, and a linear regression to test their effects at the local scale. We examined interspecific variation in species’ responses to successional age and soil nutrients with a joint species distribution model. Dispersal limitation and soil niche partitioning drove considerable variation in the composition of plant communities at local and landscape scales. The relative contribution of these two ecological processes changed with scale (local vs. landscape) and topography (lower slope vs. upper slope plots). At the species level, significant abundance–soil fertility associations were mostly positive. Most species became less responsive to soil nutrients over the first few decades of tropical forest succession, probably because light became the main limiting resource in older forests. Synthesis. Our key finding is that spatial heterogeneity in soil resources and spatial distance jointly drive compositional variation within and across early successional forests. Our results highlight that a network of forest fragments enhances the resilience of ecological processes and the potential of secondary forests to restore and preserve biodiversity in human‐modified landscapes. To advance our understanding of ecological succession, we need to move beyond single‐factor and local‐scale studies and examine the effects of multiple variables on succession at different spatial scales.
A three-dimensional computational analysis of magnetic resonance images characterizes the biological aggressiveness in malignant brain tumours

Glioblastoma (GBM) is the most frequent and aggressive type of primary brain tumour. The development of image-based biomarkers from magnetic resonance images (MRIs) has been a topic of recent interest. GBMs on pre-treatment post-contrast T1-weighted (w) MRIs often appear as rim-shaped regions. In this research, we wanted to define rim-shape complexity (RSC) descriptors and study their value as indicators of the tumour’s biological aggressiveness. We constructed a set of widths characterizing the rim-shaped contrast-enhancing areas in T1w MRIs, defined measures of the RSC and computed them for 311 GBM patients. Survival analysis, correlations and sensitivity studies were performed to assess the prognostic value of the measurements. All measures obtained from the histograms were found to depend on the class width to some extent. Several measures (FWHM and βR) had high prognostic value. Some histogram-independent measures were predictors of survival: maximum rim width, mean rim width and spherically averaged rim width. The later quantity allowed patients to be classified into subgroups with different rates of survival (mean difference 6.28 months, p = 0.006). In conclusion, some of the morphological quantifiers obtained from pre-treatment T1w MRIs provided information on the biological aggressiveness of GBMs. The results can be used to define prognostic measurements of clinical applicability.
YIELD AND AGRONOMIC EFFICIENCY OF SUNFLOWER IN RESPONSE TO NITROGEN FERTILIZER APPLICATION AND SOWING SEASON

Agronomic responses to the use of agricultural inputs have been used in agriculture to identify the optimal level of nutrients to be supplied for high yield. This strategy helps to avoid economic losses and excessive application of fertilizers that has caused pollution of aquifers and soil degradation. The aim of the study was to evaluate water use efficiency, agronomic efficiency of nitrogen, heat units and use of evapotranspiration in yield and its components in sunflowers under hot climate conditions in function of nitrogen fertilizer application during two sowing season. The experiment was conducted in the field. The treatments were two sowing seasons and three levels of nitrogen fertilizer application and one control: 0, 60, 80 and 120 kg N ha. The nitrogen source was urea. The experimental design was complete random blocks with factorial array and four replications. The occurrence of cv. Cobalto sunflower phenological stages were not modified by the treatments. Urea favored agronomic efficiency and water use efficiency. Yield components were modified positively, with increasing receptacle area, 100-grain weight, and grain yield per receptacle. Application of nitrogen fertilizer favored sunflower development, although environmental conditions are of critical importance as demonstrated by a clear interaction between the yield response to fertilizer application and the environment where the plants grew.
Evaluation of ozone oil irrigation as an adjunct to SRP in the treatment of chronic periodontitis – A randomized clinical trial

With increasing numbers of various periodontal problems one of most frequently encountered is chronic periodontitis. Although the benchmark for treatment is always scaling and root planing, non-invasive adjuncts to SRP in the form of various irrigations have shown promising results. Ozone, one of potent oxygen scavenger, is used in this study as an adjunct to non-surgical periodontal therapy. A total of 60 patients with 186 sites were selected with PPD >5 mm, PI >2, GI >2. Scaling and root planing was performed meticulously and on the same day ozonated olive oil irrigation was performed and the healing of gingiva was checked by clinical parameters after 1 month. Statistically significant reduction in PPD, plaque index has been seen at the end of period of 1 month. Use of ozonated olive oil irrigation as an adjunct to scaling and root planning showed good results in reduction of clinical parameters, in patients with chronic periodontitis.
Prevalance, Knowledge and Attitudes of Primary Care Physicians on Use of Herbal Preparations in Pregnancy

Aim: The use of herbal preparations (HPs) without considering teratogenicity potential can lead to significant health problems in pregnant women. Knowledge and attitudes of primary care physicians where pregnant women frequently consult are of great importance for patient safety. The aim of this study was to evaluate the knowledge and attitudes of primary care physicians toward HPs used during pregnancy. Methods: The cross-sectional study was conducted with 107 physicians working in family health centers in Istanbul. A self-administered questionnaire was used after getting ethics committee approval. Results: The most of physicians emphasized that the pregnant women rarely asked them for consultation of HPs use (68,2%). 29,9 % of the physicians stated that they do not inquire HPs use in pregnant patients before prescribing. Only 6,5% of the physicians prefered to recommend HPs. 21% of the physicians believe that the pregnant women should never use any HPs. Most of the pysicians (76,6%) stated that they have insufficient knowledege for advicing or prescribing any of HPs. 40,2% of the physicians think that HPs are benefit and 69,2% that the patients prefer these products because they find them harmless. Only one of the participants think there are appropriate conditions for the safe supply of herbal products Discussion: Our results showed that primary care physicians do not find themselves qualified enough to give consultancy services about the herbal remedies and they are uncertain about the content of herbal praparations.
Effects of Organizational Culture, Motivation and Work Discipline on Employee Performance with Leadership as Intervening Variables in Tanjungpinang District

This study aims to determine the effect of Organizational Culture, Motivation and Discipline on Performance and Leadership as an intervening variable. The hypothesis put forward by Organizational Culture gives an effect on Leadership, Motivation gives effect to Leadership, Discipline gives effect to Leadership, Organizational Culture gives effect to Performance, Motivation gives effect to Performance, Discipline gives effect to Performance and Leadership gives effect to Performance. The sample in this study were all employees in Tanjung pinang city and sub-districts below. The number of samples used were 95 respondents. The data in this study were obtained by distributing questionnaires filled out by respondents. The data obtained were analyzed using data analysis techniques with PLS 2.9 rock software. R Square Culture of Organization, Motivation, Discipline, and Leadership values indicate 89.0%. Thus, it can be stated that the effect of Culture of Organization, Motivation, Discipline, and Leadership, amounting to 89.0%, the remaining 11% is the contribution of other variables that have not been included in this study. The effects of Culture of Organization, Motivation, Discipline, and Leadership have a variety of significant positive and not significant, but the contribution of each in R square remains above 50%, this shows the research model is quite good. Keywords : Culture of Organization, Motivation, Discipline, Leadership and Performance DOI : 10.7176/EJBM/12-21-03 Publication date :July 31st 2020
Reading Personality Preferences From Motion Patterns in Computer Mouse Operations

Personality not only plays essential roles in people's real lives, but also becomes an important factor for various online services. Traditional approaches to personality assessment usually ask users to answer a long list of questions and are thus not practical in many online systems. It is more desirable to use some universally available data in the system to perform personality assessment. This article reports a controlled study to investigate common mouse operations as a potential new type of data source for online personality assessment. We establish an elaborate personality-mouse behavior dataset from 146 subjects and propose kinematic and adjustment features to characterize mouse motion patterns. Statistical approaches and machine learning algorithms are employed to examine the connections between personality preferences and mouse motion features via correlation analysis, discernibility analysis, and personality recognition experiments. The results reveal some interesting expressions of cognitive personality perspectives reflected in mouse motion patterns, such as fast starting acceleration and better controller. Performance evaluation shows it is possible to recognize different personality preferences using mouse motion features with accuracies ranging from 60.6 to 78.3 percent. Our findings suggest a potential to use mouse operational behaviors as a new data source for personality assessment in various information systems.
Micropropagation of an orchid Dendrobium strongylanthum Rchb.f.

A simple and reliable procedure for in vitro propagation of an orchid Dendrobium strongylanthum Rchb.f. was studied. Protochorm was induced from seed explants on 1/2 MS medium supplemented with 0.2 mg/L NAA. A mass of protochorm could be multiplied on proliferated medium of 1/2 Ms containing 0.5 mg/L V-6-BA. And bud differentiation of green global body was cultured in the same media, 2-2.5 cm shoots were formed after 30 day of culture. Addition of mashed banana and 0.5 mg/L NAA to 1/2 MS medium promoted root formation and vigorous growth. The plantlets were acclimatized and transplanted to compound materials of humus:sawdust (1:1) in greenhouse, the survival rate was more than 98%.
Metal Centers in Hydrogenases, Bimetallic Oxidases, and Model Complexes Studied by Advanced X-ray Spectroscopy Techniques and Quantum Chemistry

1 1 Preface 3 1.1 Motivation and Scope of this Thesis 5 I EXPERIMENTAL BACKGROUND AND THEORETICAL APPROACHES 7 2 X-ray techniques 7 2.1 XAS 7 2.2 XES 21 2.3 NRVS 26 2.4 TXRF 31 3 Quantum Chemistry Calculations (DFT) 33 3.1 General aspects of density functional theory 33 3.2 Functional and basis set selection 34 3.3 Geometry optimization and normal mode analysis 35 3.4 Generation of theoretical X-ray spectra 36 Overview of used programs and X-ray facilities 38
Evaluating risk of African longfin eel (Anguilla mossambica) aquaculture in Michigan, USA, using a Bayesian belief network of freshwater fish invasion

Global eel production through aquaculture has grown over 500% since the mid-twentieth century, with much of production occurring in East Asia. Recent proposal of Anguilla mossambica (Peters, 1852) (African longfin eel) aquaculture in the U.S. State of Michigan highlighted a need for greater understanding of potential risk posed by introducing this species to the United States and the Great Lakes region of North America. U.S. Fish and Wildlife Service rapid risk screening had previously characterized this species as posing “uncertain” risk to the contiguous United States. The aquaculture petition motivated a multi-expert risk assessment, an approach that promoted synthesis of published and unpublished knowledge on the poorlystudied A. mossambica along with tracking and quantification of uncertainty. A group of six scientists with expertise in eel biology, eel conservation, or fish health provided inputs to run the U.S. Fish and Wildlife Service’s Freshwater Fish Invasive Species Risk Assessment Model (FISRAM). As a Bayesian belief network, FISRAM required experts to estimate probabilities of harm to native species, ecosystems, and humans by a variety of mechanisms, as well as estimate probabilities of habitat suitability and transport. In their responses, experts emphasized lack of knowledge about many ecological interactions involving A. mossambica. However, they consistently rated its probability of transport high and expressed particular concern about concurrent introduction of the swimbladder nematode Anguillicoloides papernai (Moravec and Taraschewski, 1988) that parasitizes A. mossambica. Mean predicted probability that A. mossambica would be invasive, i.e., cause economic or environmental harm or harm to human health, was 0.24 when considering climate match to the Great Lakes basin only, and 0.57 when considering climate match to the contiguous United States. The range of predicted probabilities across experts was extreme. The State of Michigan has now used the results of this risk assessment to inform new pathogen testing and facility requirements in support of a recirculating aquaculture system (RAS) for A. mossambica in Michigan.
Industry 4.0 as a lever for innovation: Review of Serbia's potential and research opportunities

Ovaj članak istražuje premise Četvrte industrijske revolucije i njenu ulogu u podsticanju inovacija i ekonomskog rasta, ukazujući na potencijal, ali i jaz srpske ekonomije. Primenjena metodologija obuhvata pregled literature, kako u kontekstu globalnog razvoja, tako i inovacionog potencijala Srbije, kao i analizu empirijskih izvora koji bi mogli poslužiti kao osnova za buduća istraživanja. Predlaže se dublja studija razvoja blokčejna i veštačke inteligencije (i srodne automatizacije), kao i proučavanje primene drugih važnih tehnologija, kao što su robotika, računarstvo u oblaku, proširena stvarnost, 3-D štampanje i druge. Republički zavod za statistiku mogao bi da podrži ovaj proces sprovođenjem širih i redovnijih istraživanja o inovacijama, kao i prilagođavanjem svojih alata za praćenje poslovanja. Takođe se predlaže da se fokus istraživanja stavi na rezultate preduzeća i projekata koje podržava Inovacioni fond Republike Srbije, dodatno analizirajući njihov uticaj na šire inovacione delatnosti. Konačno, istraživanja bi trebalo nastaviti i u povezanim oblastima integracije ljudskog kapitala i znanja, finansiranja poslovanja i regulatornog i infrastrukturnog okvira.
Screening of Rhizosphere Bacteria from Clove (Syzygium aromaticum) in Tidore Island as Plant Growth Promoting Rhizobacteria

Tidore Island in North Maluku Province is one of the clove ( Syzygium aromaticum ) producing regions. Clove plant fertility is maintained even though it is not given organic and inorganic fertilizers, it also keeps the fertility of the soil and the environment as a whole. Therefore, this study aims to explore bacteria in the rhizosphere of the clove trees planted in Tidore island as biofertilizer agents of Indol-3-Acetic Acid (IAA) production, phosphate solubilization, and ammonium production. Bacteria were isolated from the rhizosphere of clove trees. Screening of the isolates was done according to qualitative and quantitative methods. Data collection of the qualitative method were based on medium color changes for each variable while that the quantitative method (i.e. the concentrations of produced IAA, solubilized phosphate, and produced ammonium) were obtained based on spectrophotometry. The results obtained 110 bacterial isolates. Nineteen bacteria were potential as biofertilizer agents, of which isolate R11, R8P, and A1N showed the highest in IAA production (8.71 μgL -1 ), phosphate solubilization (8.37 μgL -1 ), and ammonium production (11.71 μgL -1 ), respectively. The three isolates respectively have similarities to the genus of Enterobacter, Burkholderia , and Stenotrophomonas. Keywords: Biofertilizer, Clove, Rhizobacteria, Rhizosphere.
EFFECTS OF COVID-19 ON PHYSICAL ACTIVITY BEHAVIOR AMONG UNIVERSITY STUDENTS: RESULTS OF A HUNGARIAN ONLINE SURVEY

Background Due to COVID-19, social isolation and home confinement have changed daily behavior in Hungary since the pandemic hit in early 2020 This study aimed to examine physical activity (PA) patterns among young adults before and during distancing and lockdown safety measures Material and methods We recruited 827 students online across 10 faculties at the University of Pecs during April and May 2020 PA level (IPAQ-SF) and self-rated physical and mental health status were examined The level of significance was set at p&lt;0 05 Results Students' perceived mental health status proved to be worse than perceived physical health, while the percentage of individuals who did not engage in any sports decreased from 37 61% to 29 26% Total PA levels and walking times were decreased, while sitting time significantly increased (p&lt;0 001) A positive correlation was found between perceived physical health and total PA (R=0 215, p&lt;0 001) as well as between perceived mental health and walking (R=0 091, p=0 009) and total PA (R=0 106, p=0 002) Conclusions We found decreased a mounts of PA among university students during the COVID-19 pandemic period, which highlights the need to promote a physically active lifestyle in cases of social restrictions