Miracle-dz/UniFAR-FTUs huggingface dataset:
Sequence variation in the CD36 gene and its relationship with plasma HDL cholesterol levels

Heart disease (HD) is a primary public health concern, with HD being one of the leading causes of death every year in the United States. Many risk factors influence HD, including lipid levels, and studies have shown that higher levels of plasma high density lipoprotein (HDL) cholesterol have a protective effect against HD. Recent genome-wide linkage scans have associated a locus on chromosome 7, harboring CD36, as being involved in components of the metabolic syndrome, including HDL-C levels. Therefore, identifying variation in this gene affecting HDL-C levels is of great public health importance. The "common variant-common disease" hypothesis has been tested by a limited number of studies through common SNP genotyping with inconsistent results. To date, no studies to our knowledge have evaluated CD36 using the "rare variant-common disease" hypothesis. The aim of this study was to further evaluate the role of common and rare variation in CD36 by sequencing individuals having extremely low and high HDL-cholesterol levels in two populations, U.S. Non-Hispanic Whites (NHWs), and African Blacks. In our initial sequence analysis, 343 variants were identified in CD36, 168 of which were previously unreported in the SeattleSNPs database. According to preliminary analysis of the sequencing data, our findings support the associations of three SNPs with HDL-C levels reported in the literature. No striking difference was noticed between the distribution of rare variants between high and low HDL-C groups. We identified four common variants (MAF ≥ 5%) in our sequencing data from our small sample that displayed statistically significant differences in MAF between the low and high HDL-C groups but have not been confirmed yet by genotyping in the entire NHW and Black populations while thirteen common variants had p-values between 5-10%, which may be statistically significant due to the small sample size. To date, screening data was compiled for the entire NHWs and Black samples for a total of nineteen common variants. None of these variants displayed a significant p-value in our entire NHW and Black samples. Additional variants identified in sequencing remain to be screened in the entire NHW and Black samples.
Population changes in natterer's bat myotis nattereri and daubenton's bat m. Daubentonii in winter roosts of central Poland

ABSTRACT: Numbers of wintering Natterer’s bats Myotis nattereri (Kuhl, 1817) and Daubenton’s bats M. daubentonii (Kuhl, 1817) were monitored at seven study sites (three single large hibernacula and four groups of roosts) in central Poland. The lon-gest monitoring period was 1987–2009, the short-est – 1999–2009. The aim of the study was to find out if the numbers of the two species are stable, or if any trends could be detected. For most of the study period, bats were counted twice during each hiber-nation season: in autumn (November/December) and in winter (January/February). The numbers of Natterer’s bats show a strong increase all over the study area – a trend similar to that reported ear-lier from other parts of the country. Daubenton’s bats, on the other hand, declined in the hibernac-ula located in the north-eastern part of the study area, while in those located in the south-western part their numbers were stable or even slightly in-creased. A decrease in the numbers of Daubenton’s bats is in contrast with reports from other hiber-nacula in Poland and elsewhere in Europe, where the species increases in numbers. The changes in the numbers of both studied species could be ex-plained by neither changes in the hibernacula nor weather conditions during the study period, so our results probably reflect changes in the numbers of local populations.
The signalling pathways allowing hormonal regulation of Na+ transport in murine collecting duct cells

The collecting duct of the distal nephron marks the final location where adjustments to Na + excretion can be made, therefore determining the final concentration of Na + conserved in the extracellular fluid which plays a role in governing overall blood volume and pressure. This transport of Na + is subject to hormonal regulation but the signalling pathways underpinning this regulation however, are not fully understood. In this thesis the signalling pathways allowing both basal and insulin-stimulated Na + absorption were explored in the murine collecting duct cell line, mpkCCDcl4. The effects of two insulin-sensitizing drugs, TZDs, on ENaC-mediated Na + transport were investigated and the signalling pathways underlying two other hormonal regulators of ENaC, dexamethasone and vasopressin, were also examined. Unstimulated monolayers of mpkCCDcl4 cells generated spontaneous Na + absorption which was quantified by measuring equivalent short circuit current (Ieq). Selective inhibition of PI3-kinase, mTORC2 and SGK1 left ~80 % of the current intact, indicating these signalling molecules are not required for basal Na + transport. Acute addition of insulin stimulated Ieq and this occurred with a concomitant increase in mTORC2, SGK1 and Akt activity. Inhibition of PI3kinase abolished the insulin-stimulated response as well as phosphorylation of downstream substrates, indicating a crucial role of PI3-kinase. Inhibition of mTORC1 with rapamycin did not alter basal or insulin-stimulated Na + transport. The mTOR inhibitors TORIN1 and PP242 could therefore be used to evaluate the role of mTORC2. These inhibitors greatly reduced insulin-stimulated ENaCmediated Na + transport and also abolished SGK1 and mTORC2 activity, indicating a novel role of mTORC2. An inhibitor of SGK1, GSK650394A abolished insulin-stimulated Na + transport and specifically inhibited SGK1 acitivty demonstrating the importance of SGK1 in insulin signalling. The inhibitor Akti-1/2 also abolished insulin-mediated Na + transport but this compound inhibited both Akt and SGK1 activity. The TZDs pioglitazone and rosiglitazone
Faut-il complémenter les vaches laitières au pâturage?

L'herbe pâturee est un fourrage de valeur nutritive elevee, peu couteux a produire et a recolter et qui peut constituer le seul aliment de la ration de la vache laitiere. En l'absence de toute complementation, la production et la composition du lait d'une vache laitiere au pâturage depend d'abord de l'animal et de son potentiel au moment de la mise a l'herbe. Mais les conditions de pâturage (chargement, hauteur en debut et fin de parcelle) imposees par l'eleveur pour valoriser au mieux l'herbe produite ne permettent pas aux vaches laitieres de satisfaire la totalite de leurs besoins energetiques. En consequence, l'apport de concentre est aujourd'hui plus efficace que par le passe et des reponses de 1 kg de lait par kg de concentre, accompagnees d'une baisse du taux butyreux et d'une augmentation du taux proteique, sont souvent rapportees. Les travaux recents conduits a l'INRA montrent que cette efficacite varie peu dans les conditions habituelles de pâturage. De meme, dans le cas d'apport identique de concentre entre vaches, l'efficacite semble independante du niveau de production entre 25 et 45 kg de lait par jour a la mise a l'herbe. Ces resultats permettent de proposer des simplifications dans les modalites d'attribution du concentre au pâturage. Comme en alimentation hivernale, la nature de l'energie du concentre n'a reellement d'influence sur la composition du lait (taux butyreux) que pour des quantites elevees, superieures a 5 kg de concentre. L'incorporation de matieres premieres riches en proteines, meme protegees, ne se justifie que dans le cas d'herbe pâturee pauvre en azote. L'apport de fourrages complementaires au pâturage presente peu d'interet et, dans la pratique, contribue souvent a une degradation des conditions de pâturage. Seules les situations de penurie fourragere ou de chargement tres eleve permettent de bien valoriser a la fois l'herbe pâturee et les fourrages conserves distribues en complement.
Study on birth weight and pre-weaning growth of Croatian multicolored goat kids.

The aim of this research was to determine some production characteristics of Croatian multicolored goat kids (birth weight, age and body weight at weaning, and average daily gain) in extensive breeding conditions. The research included 530 goat kids from four family farms in the area of Sibenik – Knin and Zadar County. Birth weights and body weight of kids at weaning were determined by individual weighing by an electronic scale with accuracy of ± 0.05 kg. Kids were with goats from birth to weaning and they were consuming pasture and browse while consuming milk by suckling. The results of the research indicate that kids’ birth weights, their body weight at weaning and average daily gain are quite variable and under the influence of sex, type of birth and the season of kidding. After the parturition, kids weighed 2.28 kg in average, and 23.0 kg at weaning (on the 186th day). Kids were gaining daily 115.43 g in average in the period from birth to weaning, but in comparison to female kids, male kids had significantly (P<0.001) higher average daily gain (125.15 : 106.96 g) and significantly (P<0.05) higher body weight at weaning (23.46 : 22.58 kg). The lowest average daily gain (103.92 g) was determined in kids of low birth weight (< 1.50 kg), and the highest (163.04 g) in kids of higher birth weight (≥ 3.50 kg). A significant (P<0.001) influence of kidding season on birth weight and growth of kids from birth to weaning was determined.
SNAP-25 is a component of a ubiquitous SNARE complex required for evoked neuroexocytosis in GABAergic neurons

Biomedical Sciences Graduate Program University of New Mexico School of Medicine Student’s Name: Lawrence C. Tafoya Date: December 5, 2006 Proposed Dissertation Title: SNAP-25 is a component of a ubiquitous SNARE complex required for evoked neuroexocytosis in GABAergic neurons Proposed Date of Completion: December 2007 Attach 10 – 15 single-spaced, typewritten pages with the following information: 1. Background: What are the most significant previous findings that impact on or motivate your research? 2. Hypothesis 3. Specific Aims: What are the specific aims of the dissertation research? Include the questions to be answered and the hypothesis to be tested. 4. Methods and Experimental Design: Outline your approach to the project, and describe the experimental techniques you will use.
The relationship between macroeconomic variables and non performing loan: evidence from selected ASEAN countries

High non-performing loans (NPLs) create the problem for the banking sector as financial intermediary and signal of banking crisis. Many attempts have been made to investigate the determinant of NPLs yet the crucial issue has remained unexplained. The motivation of this research paper is to study the relationship between macroeconomic variables and global financial crisis on NPLs in the Association of Southeast Asian Nations (ASEAN) countries. Using panel data of 6 countries of the ASEAN for 2005-2015, the model of NPL is regressed using Generalized Method of Moment (GMM) method. Based on the empirical finding reveals that the inflation, gross domestic product (GDP) and global financial crisis significantly effect NPL. In the area of policy implications, the policymaker should focus and reengineering the institutions together with these indicators could reduce the probability of NPLs in bank of ASEAN countries.
Accuracy Evaluation of Daily-gridded ASCAT Satellite Data Around the Korean Peninsula

In order to access the accuracy of the gridded daily Advanced Scatterometer (hereafter DASCAT) ocean surface wind data in the surrounding of Korea, the DASCAT was compared with the wind data from buoys. In addition, the reanalysis data for wind at 10 m provided by European Centre for Medium-Range Weather Forecasts (ECMWF, hereafter ECMWF), National Centers for Environmental Prediction and National Center for Atmospheric Research (NCEP/NCAR, hereafter NCEP), Modern Era Retrospective-analysis for Research and Applications -2 (MERRA-2, hereafter MERRA) were compared and analyzed. As a result, the RMSE of DASCAT for the actual wind speed is about 3 m/s. The zonal components of wind of buoys and the DASCAT have strong correlation more than 0.8 and the meridional components of wind them have lower correlation than that of zonal wind and are the lowest in the Yellow Sea (r=0.7). When the actual wind speed is below 10 m/s, the EMCWF has the highest accuracy, followed by DASCAT, MERRA, and NCEP. However, under the wind speed more than 10 m/s, DASCAT shows the highest accuracy. In the nature of error according to the wind direction, when the zonal wind is strong, all dataset has the error of more than 70° on the average. On the other hand, the RMSE of wind direction was recorded 50° under the strong meridional winds. ECMWF shows the highest accuracy in these results. The RMSE of the wind speed according to the wind direction varied depending on the actual wind direction. Especially, MERRA has the highest RMSE under the westerly and southerly wind condition, while the NCEP has the highest RMSE under the easterly and northerly wind condition.
MATURITY STAGES OF INDIAN OIL-SARDINE, SARDINELLA LONGICEPS VAL., WITH NOTES ON INOiDElJCE OF ATRETIC FOLLICLES IN ADVANCED OVARIES

WORKERS engaged in research on the maturity and spawning conditions offish have prepared different types of maturity scale according to the peculiarities presented by different fishes studied by them. Except for a few remarks about the external appearance of ovaries belonging to stages V to VII by Devanesan (1942), there is no detailed account of the different stages of maturity for Sardinella longiceps. Nair (1959) has adopted the maturity scale prepared by the International Coij^cil for the Exploration of the Sea for investigations on oil-sardine. However, when studies on the maturity and spawning habits of oil-sardine were taken up by the author, the absence of a detailed classification was keenly felt and since the International key was found to be not adequate enough to distinguish the different stages, it was considered necessary to prepare a detailed scale for the guidance of workers both in the laboratory and the field so that confusion in the interpretation and assignment of the stages of maturity can be avoided and a uniformity in . eporting achieved
EFFECT OF THE PRODUCTION SEASON ON NUTRITIONAL VALUE AND TECHNOLOGICAL SUITABILITY OF MILK OBTAINED FROM INTENSIVE (TMR) AND TRADITIONAL FEEDING SYSTEM OF COWS

The seasonal variations in milk yield and its chemical composition arise mainly from changes in feeding of the cattle in different seasons of the year. A constant quantity of production and a similar quality of the raw material supply farms, where the feeding of cows is uniform throughout the year (TMR and PMR). The study included 1211 samples of milk obtained in the summer season (663) and in the winter season (548) from cows maintained in traditional and intensive (TMR) system of production. Following parameters were determined: content of fat, protein, casein, lactose and dry matter; acidity (pH value); heat stability; rennet coagulation time; content of α-lactalbumin, β-lactoglobulin, bovine serum albumin, lactoferrin, lysozyme and fatty acid profiles. Cows fed in the TMR system produced significantly (P≤0.01) more milk and of a better chemical composition regardless of the season of production. Milk obtained from cows fed traditionally had the most profitable protein to fat ratio (0,90) and the shortest time of rennet coagulation (3:26 min). It contained significantly (P≤0.01) more whey proteins and had better fatty acid profiles for health. In addition the differences were usually larger in the summer season than in the winter season. It is possible to state that in summer season, when the animals are maintained on the pasture, JMBFS / Barłowska et al. 2012 : 1 (5) 1205-122
The Incidence of Coxiella burnetii Infection in Ewes in Elazığ and Neighboring Provinces

This study was carried out to determine the incidence of C.burnetii infection using the Indirect Fluorescent Antibody (IFA)Test in ewes in Elazig and neighboring provinces.Seropositivity was detected in 38.59 %(71/184)of aborted ewes and in 11.01 %(25/227)of unaborted ewes.The seropositivity rates were 20 %in Elazig,20% in Malatya, 27.95 %in Bingol and 27.27% in Mus. Antibody titers ranged from 1/80 to 1/1280. Q fever should be considered an important cause of abortions in ewes in Elazig and neighboring provinces.
The Ecology of Phytoplankton

Communities of microscopic plant life, or phytoplankton, dominate the Earth's aquatic ecosystems. This important new book by Colin Reynolds covers the adaptations, physiology and population dynamics of phytoplankton communities in lakes and rivers and oceans. It provides basic information on composition, morphology and physiology of the main phyletic groups represented in marine and freshwater systems and in addition reviews recent advances in community ecology, developing an appreciation of assembly processes, co-existence and competition, disturbance and diversity. Although focussed on one group of organisms, the book develops many concepts relevant to ecology in the broadest sense, and as such will appeal to graduate students and researchers in ecology, limnology and oceanography.
Carcass Characteristics of Chokla And Avikalin Yearling Males Maintained Under Grazing With Supplementation

The present study was undertaken to assess meat yield efficiency and carcass characteristics of native Chokla and Avikalin yearling male lambs maintained on grazing with concentrate supplementation. Pre-slaughter weight, empty live weight and hot carcass weight were similar in Chokla and Avikalin yearling males. The dressing yield in terms of pre-slaughter weight and empty live weight were however, higher (P<0.01) in Avikalin than Chokla amounting to 43.6 and 39.7, 53.7 and 50.2%, respectively. The cut yields of leg, neck and shoulder and breast and fore shank were almost similar in both the breeds. The loin cut yield was however, higher (P<0.05) in Chokla while the rack cut yield was higher (P<0.05) in Avikalin. The lean and fat content of neck and shoulder and breast and fore shank cuts were significantly (P<0.05) higher in Chokla than Avikalin. The caul and kidneys fat % were also higher (P<0.01) in Chokla than Avikalin. In the variety meat, liver weight was higher (P<0.01) in Chokla (1.8% of PSW) than Avikalin (1.6% of PSW) whereas the kidney, heart, testicle, spleen weights were similar in the 2 breeds averaging to 0.28, 0.41, 0.79 and 0.16%, respectively. The skin weight was significantly (P<0.05) higher in Chokla (9.45% of PSW) whereas percentages of the head and lungs with trachea were higher (P<0.05) in Avikalin. It is concluded that the yearling Avikalin and Chokla male lambs raised on grazing with supplementation provided carcass of acceptable quality. Moreover, the higher depot fat content of Chokla indicated that the feeding protocol was adequate for the breed while Avikalin because of their higher requirements were at a disadvantage.
Micro-morphological study of Polygonaceae tribes in Iran

As a family, Polygonaceae has a complex taxonomic historical position that experienced different treatment in the floras. In order to clear delimitation of its tribes in Iran, in this study we consider the macro and micro- morphological features of tepal epidermis, dorsal leaf epidermis, achene surface, and pollen grains in 10 populations from different habitats in Iran. The results of cluster analysis have revealed that Rumiceae has an interesting position in phenogram topology. Micro-morphological characters proved more efficient in the separation of Persicarieae elements in Iran than in two other tribes. The results of this project show distinctly Polygonum s. str. and Persicaria as separate genera in the flora of Iran.
Indirect Effect of Fungicide Treatments on Chasmothecia of Erysiphe necator Schwein Overwintering on Grapevine Bark

Hoffmann P., Fuzi I. , Viranyi F. (2012): Indirect effect of fungicide treatments on chasmothecia of Erysiphe necator Schwein overwintering on grapevine bark. Plant Protect. Sci., 48: 21–30. Erysiphe necator Schwein overwinters in Hungary primarily as large numbers of chasmothecia providing primary inoculum for grapevine (Vitis vinifera L.) infection in the next year. In two field trials, the effect of fungicide treatments on powdery mildew severity and the number of chasmothecia produced on leaves and washed to the bark were studied. In 2005, the number of chasmothecia harvested from the bark showed a limited correlation with disease severity ( r = 0.553) and number of chasmothecia on leaves ( r = 0.600). In 2006, using a refined siev ing technique, a substantial increase in the number of harvested chasmothecia could be achieved resulting in a much closer correlation between the variables above (r = 0.750 and r = 0.886, respectively). Among the fungicides applied, boscalid and fluquinconazole (SC formulation) showed the most significant activity by decreasing both the autumn leaf infection and the formation of chasmothecia on the leaves and providing the lowest number of chasmothecia on bark. The research underlined the importance of fungicide applications made in the previous year to decrease the amount of overwintering inoculum and to help protect grapevines from powdery mildew infection in the next year.
Rapid Detection of Bacterial Antibiotic Resistance: Preliminary Evaluation of PCR Assays Targeting Tetracycline Resistance Genes

Abstract : The rapid spreading of bacterial antibiotic resistance and the lack of methods that would allow fast and accurate determination of the resistance profile of an infectious agent have become a major concern for public health. In the context of biological warfare or a bioterrorist attack, resistance against commonly used antibiotics would severely compromise the capabilities of the responsible agencies to protect large numbers of exposed individuals against a potentially lethal infection. In this study the possibility of developing polymerase chain reaction (PCR) assays for rapid detection of tetracycline resistance genes was evaluated. PCR assays were designed for seven resistance genes that frequently occur in Gram-positive and Gram-negative species and tested on eight tetracycline resistant clinical isolates. Positive results were obtained from seven of the eight species tested.
Developmental biology of Amblyseius californicus (McGregor) (Acarina: Phytoseiidae), a predator of tetranychid mites, at three temperatures

The development time, survival and fecundity of Amblyseius californicus (McGregor), a predatory mite in deciduous fruit orchards, were determined at 20,25 and 30 C. Using these values the intrinsic rate of increase (rm), mean generation time (T) and net replacement rate (Ro) were estimated at the respective temperatures. In addition, the data were used to estimate the minimum temperature required for development. The rm increased with increasing temperature from 0.122 at 20 C to 0.251 at 30 DC. The Ro was highest at 25 C (11.18 females/female) and was lower at 20 DC (9.71 females/female) than at 30 DC (10.54 females/female), while T decreased with increasing temperature from 20.11 days at 20 C to 10.20 days at 30 C. The estimated minimum temperature for development was 8.3 DC, which indicates that A. californicus could survive the winter on plants in the covercrop in orchards and should be able to control populations of the phytophagous mite, Tetranychus urticae Koch, at temperatures below 30 C.
Yield components analysis in American cotton (Gossypium hirsutum L.).

Evaluation of 42 upland cotton genotypes revealed high heritability with high GCV and genetic gain for number of bolls, number of sympodia, boll weight and plant height and these could be improved by simple selection. Correlation and path analysis studies revealed that number of sympodia, number of bolls, number of seeds and boll weight had significant positive association with seed cotton yield per plant in addition to exhibiting direct positive effect on it.