Miracle-dz/UniFAR-FTUs huggingface dataset:
Caloric Restriction Diet (CR diet) or Mediterranean Diet (MD) - Which is the Best Choice for Former Athletes?

Overweight or obesity which often develop in athletes who end their careers is one of the most important issues of the world of sport. During aging, an increase in the amount of intra-abdominal fat is observed; this fat increases the risk of such metabolic disease as diabetes or hypertension. The participants of the study were 94 males. The people were randomly assigned to one of 2 groups: group 1 – people using the diet based on calorie restriction CRON (n = 32), and group 2 – those who followed the recommendations of the Mediterranean diet (n = 34). The patients who at the check-up declared not following any diet were assigned to the control group (n = 28). A change in parameters was observed in each of the sub-groups after the intervention. The most significant changes were observed in the sub-group which lost >2.6 kg. Both the diet based on mild calorie restriction and the Mediterranean diet had positive effect on the change of the former athlete’s body parameters after the 6-week long dietary intervention. Both diets which were being tested changed the body composition of the athletes who ended their careers in a similar way.
Preliminary Study on Bacterial Diversity Causing Human Foot Odor

This preliminary study was aimed at studying on microbial diversity causing odor of the human foot. The objective was to know the main bacteria species causing foot odor. The method used in this study was foot swab by using cotton buds for bacterial isolation, tests for H2S gas formation by using Kligler Iron Agar solid medium, odor test and optical density value. There were 204 bacterial isolates collected from 30 people ranged from 7-40 years old. They were identified based on polyphasic characterization. Based on 50 cultures of 25 isolates, it was indicated that sweat filtrate was better medium for bacterial growth than shocks filtrate. This was indicated that the odor problem was from sweat which was consisted of bacterial growth producing unpleasant odor. These were shown by the H2S producing-bacteria such as Bacillus cereus and Proteus mirabilis were isolated from the foot. Those bacteria were identified based on their partial sequences of 16sDNA. Other bacteria isolated were Acinetobacterpittii, Enterobacterhormaecheisubsp. xiangfangensis, Enterobactermori, Glutamicibactercreatinolyticus, Klebsiella pneumonia, Leclerciaadecarboxylata, and Staphylococcus warnerii.Further study will be carried out to use bacteriophages for eliminating bacterial biofilm in vitro. Bacteriophage uses for prevention application for human foot odor by bacterial growth is much prospective than other application such as sanitizer or disinfectant.
Minority Shareholders’ Satisfaction On Corporate Transparency

The concept of transparency is not a new concept and it has been the interest of the corporate research literature for a few decades. This research paper is to study the relationship between the minority shareholders’ satisfaction and the six key variables of disclosures that are corporate information disclosure, financial information disclosure, corporate governance disclosure, dividend disclosure, voting right disclosure and corporate transparency between female and male. From the findings of this study, overall the minority shareholders are satisfied on the corporate transparency of the public listed companies in Malaysia. This also indicates that the level of corporate transparency is quite high. This is mainly because most of the information measured in this research are mandatory to be disclosed. In conclusion, most minority shareholders from Klang Valley area are satisfied with the corporate transparency of the public listed companies in Malaysia.
THE RELEASE OF ENDOGENOUS GLUTAMATE FROM THE NEWBORN RAT SPINAL CORD INDUCED BY DORSAL ROOT STIMULATION AND SUBSTANCE P

The release of endogenous glutamate and aspartate from the hemisected spinal cord of newborn rats was measured by mass fragmentography. Repetitive stimulation applied to the dorsal roots produced a small but significant release of glutamate. The evoked release of aspartate was smaller than that of glutamate and statistically insignificant. In the low Ca solution, the release of glutamate evoked by dorsal root stimulation was significantly decreased. The bath application of substance P (SP) produced electrical activities in the ventral root and caused a significant increase in the release of glutamate. The aspartate release induced by SP was small and statistically insignificant. In the low Ca or tetradotoxin (TTX) solution, the release of glutamate induced by SP was decreased or abolished. The SP-induced release of aspartate was almost unaffected by the low Ca and TTX solutions. It is suggested that glutamate is the principal transmitter released by dorsal root stimulation and by SP.
SELF PERCEPTIONS OF STUDENTS’ HUMANITIES-BASED SKILLS IN AN ENGINEERING PROGRAM: OVERVIEW OF FIRST YEAR RESULTS

Demonstrating and improving assessment of humanities-based graduate attributes can be challenging, as there are no easy metrics in order to do so. Engineering programs offer curricular and co-curricular programming in order to improve these attributes in their students and still find it challenging to determine if those initiatives are in fact effective. To those ends, in order to assess engineering accreditation humanities-based skills, a threeyear longitudinal study was implemented at a medium sized engineering school at a large research university. In particular, the survey focuses on engineering students selfperceptions of teamwork, communication skills, engineering ethics, professionalism, and lifelong learning in order to gather quantitative data that can be analysed for trends. This paper overviews the data gathered in the first year of the longitudinal study and offer preliminary explanations of those results and what they can offer to our understanding of humanities-based graduate attributes offered in our engineering programs.
The Road to Optimized Nerve Reconstruction

markdownabstractTraumatic injuries to the peripheral nerves cause considerable disability and economic burden. It is estimated that 5% of patients admitted to Level I trauma centers have peripheral nerve injury. The reconstruction of peripheral nerve defects remains a clinical challenge. The gold standard for nerve injuries that cannot be directly reconstructed is the use of a bridging autologous nerve graft. The use of autograft nerve is limited by supply, diameter, and length, and has associated donor site morbidity. This has constrained the ability to optimally reconstruct injured nerves of patients with multiple segmental defects and resulted in the prioritization of which nerves to reconstruct. This thesis focuses on reconstruction of peripheral nerve defects and highlights the clinical problem and focuses on the optimization of a decellularized nerve allografts.
TOURMALINE-MM1: new oral triplet combination for patients with relapsed/refractory multiple myeloma

The treatment of multiple myeloma (MM) radically changed 11 years ago when the addition of Thalidomide to Melphalan-Prednisone (MPT) was proven to be superior to Melphalan-Prednisone (MP) alone (1). Various other compounds have been approved since, changing the landscape of MM treatment at diagnosis and in the relapse setting. Despite all these improvements, the vast majority of patients still relapse and the management of this group of patients can be challenging. In particular those patients relapsing after Bortezomib and Lenalidomide (the backbone of treatment for MM) have a poor outcome with a median event-free survival (EFS) of 5 months and a median overall survival (OS) of 9 months (2).
Characterisation of the single-stranded DNA binding protein encoded by Kaposi's sarcoma herpesvirus.

The work presented in this thesis is on the characterisation of the single stranded DNA (ssDNA) binding protein of the human herpesvirus, Kaposi's sarcoma herpesvirus (KSHV), encoded by the ORF6 gene. There is a core set of six proteins conserved throughout the herpesvirus family that are required for viral DNA replication and are active at the replication fork. These proteins function as a DNA polymerase and its processivity factor, a trimeric helicase-primase complex and a single-stranded DNA binding protein. In KSHV these functions are carried out by the proteins expressed by the following genes: 0RF9 (DNA polymerase), ORF59 (processivity factor), ORF56 (helicase), ORF44 (primase), ORF40/41 (helicase-primase associated factor) and ORF6 (single-stranded DNA binding protein). Current models of herpesvirus DNA synthesis are based mostly upon knowledge of the herpes simplex virus type 1 (HSV-1) replication fork proteins, which have been more extensively studied than any of their homologues in other herpesviruses. The DNA replication proteins in KSHV have not been well studied and therefore their roles in KSHV DNA synthesis have been largely predicted by analogy with their HSV-1 counterparts.To date there has been no published characterisation of the KSHV ssDNA binding protein (pORF6). The work completed for this thesis describes the over-expression and purification of pORF6 and characterisation of its binding to ssDNA. A recombinant baculovirus expressing pORF6 was constructed and used to infect Spodoptera frugiperda cells. The protein was purified from these cells using heparin sulphate and mono-Q columns. Following successful purification of pORF6 it was established that it could bind to ssDNA, using an electrophoretic mobility shift assay (EMSA) and surface plasmon resonance measurements on a BIAcore instrument. The number of nucleotides required for pORF6 to bind to ssDNA and the effect of NaCl on binding were also investigated, revealing that optimal binding occurred at 150 mM NaCl. Fourteen nucleotides were required for pORF6 to bind, however, binding became more efficient as the length was increased to twenty. ICP8, the HSV-1 homologue of pORF6 has been shown to bind to ssDNA in a cooperative manner. The binding mechanism of pORF6 to a ssDNA of thirty-two nucleotides was investigated, again using an EMSA and surface plasmon resonance. This revealed that pORF6 may also bind to single-stranded DNA cooperatively. A comparison of ICP8 and pORF6 binding to ssDNA using the BIAcore indicated that they bind to single-stranded DNA with a similar affinity. A panel of monoclonal antibodies was generated against pORF6 and was tested by western blotting, immune-fluorescence and immune-precipitation, using Spodoptera frugiperda cells infected with a recombinant baculovirus expressing pORF6. Human B-cells infected with KSHV that had been induced into their lytic cycle were also used in immune-fluorescence assays, which revealed pORF6 to be present in globular areas within the cell, reminiscent of herpesvirus DNA replication compartments.
Parents Communication Pattern for Schools in the Management of Students with Special Needs

: This research aims to describe: (1) the school’s strategy in communicating the management of students with special needs; and (2) interest parents in the management of students with special needs. This study used a qualitative approach, with a case study research plan. This research place in SD Plus Al-Kautsar Malang city. Data collection techniques with in-depth interviews, observation of roles and documentation. Data analysis techniques used are reduction, display data, and conclude. Results of this study: (1) through the class of parents communicating to the shadow teacher, and the class parents communicate directly to the students’ parents; and (2) each year there are always students with special needs who register, empowering shadow Teacher As an intermediary between school and parents and the use of some media as a liaison of parents with schools.
Implementation of Blended Learning using Schoology On the Topic of Invertebrate to Improve Student Learning Outcomes

Invertebrate is a very wide topic, that includes approximately eight phyla. Problem in teaching this topic is the limitation in time to achieve many learning indicators. The alternative efforts to overcome this problem is by implementing the blended learning. Blended learning is a kind of learning that combines face-to-face learning in the classroom and online learning that can be conducted everywhere. This study aimed to evaluate the learning process of blended learning using Schoology, student responses and students learning outcomes of invertebrate material through blended learning using Schoology. This research was conducted by involving 33 students of Grade X by using one group pre-test and post-test design. Data obtained were learning process based on lesson plan and student activities, student responses as well as students learning outcomes. Instruments used were observation sheets, responses questionnaires, as well as pretest and posttest sheets. The data of learning process and student activities were analyzed descriptive-quantitatively. Data of learning outcomes were analyzed based on learning mastery and gain score. The results of this study indicated that learning process of both face-to-face learning and online learning were very successful, students also gave very good responses to the implementation of blended learning. In addition, its proven that the implementation of blended learning can improve the student learning outcomes significantly.
The potential of internal social capital in organizations: An assessment of past research and suggestions for the future

ABSTRACT This study’s purpose was to synthesize the structure and content of the internal social capital (ISC) literature within business management refereed journals from 1989 to 2017 and to propose future directions for study. Performance indicators, bibliographic coupling, and content analysis were used to conduct the literature review. One hundred twenty-eight documents were organized in eight conceptual theme clusters addressing ISC’s definition, structure and behavioral dynamics, function of bonding, capacity building, and culture setting. The review also addressed performance enhancements and constraints that emanate out of ISC processes. In addition, it addressed the unique contextual ISC relevance of the family influence in family businesses. Gaps in the literature are discussed and a series of future research directions are posed for each of the eight thematic clusters that evolved from the literature review analysis.
Elemental composition of mammals in natural and anthropogenic areas and their ranking using the USEtox model

The geochemical heterogeneity of the biosphere, due to different natural and anthropogenic conditions, is changing significantly as a result of the development of man and society. Modern geo-ecological studies of different territories prove the fact of close connections of living organisms with the environment. However, little attention is paid to the complex approach, for example with the use of the model of impact assessment on living organisms. The Life Cycle Assessment (LCA) method, is allowed the magnitude and significance of the impact on the environment and the human organism to be monitored. The characteristic coefficient (CF) - is a tabular value, proposed by the model, depending on the region's location. In this thesis, however, it is proposed to modify this coefficient by introducing the results of biogeochemical analysis of territories with different ecological situations, in order to rank them more precisely. It is this modification, which determines the relevance of the study. The PhD thesis is purposed to assess the geo-ecological state of local areas of Russia and Kazakhstan with the use of indicators of the elemental compositions of organs and tissues of mammals, and a ranking of the toxicity of individual elements using the USEtox model. The modification method of the USEtox impact assessment model, using the results of the chemical analysis, can be used as a local supplement in the assessment of toxic effects on the population.
Jurassic neoselachian sharks from the Mt Nerone Pelagic Carbonate Platform (Umbria-Marche Apennine, Italy): a further constrain for the palaeoecology related to PCP systems

ABSTRACT The Mt Nerone area hosts a Jurassic-Cretaceous Pelagic Carbonate Platform (PCP)-basin succession in the Umbria-Marche Domain (Central Italy). Despite being studied thoroughly on sedimentological and geological aspects, wide-spectrum palaeocological studies are currently missing for this peculiar setting. While several studies on the invertebrate fauna of PCP system are available, the vertebrate fauna remained for a long time mostly unknown. Recently a renewed interest has been directed to vertebrate remains of the region. To date, an articulated dentition and some other tooth fragments of hybodont sharks and neoginglymodian actinopterygians have been described from the Jurassic of the Mt Nerone area. These taxa indicate the existence of diverse durophagous ecological niches available for durophagous fauna in the PCP system, linked to the abundant hard-shelled invertebrate fauna inhabiting the structural highs. In the present contribution we report and describe remains of neoselachians Synechodontiformes from five localities of the Mt Nerone area. The new material, represented by several isolated teeth and referred to as Sphenodus spp. , testifies an additional trophic level for the Jurassic palaeoecology in the Umbria-Marche Domain, throwing new light on the peculiar PCP-basin ecosystem.
Metastasis-Specific Gene Expression in Autochthonous and Allograft Mouse Mammary Tumor Models: Stratification and Identification of Targetable Signatures

Breast cancer metastasis is a leading cause of cancer-related death of women in the United States. A hurdle in advancing metastasis-targeted intervention is the phenotypic heterogeneity between primary and secondary lesions. To identify metastasis-specific gene expression profiles we performed RNA-sequencing of breast cancer mouse models; analyzing metastases from models of various drivers and routes. We contrasted the models and identified common, targetable signatures. Allograft models exhibited more mesenchymal-like gene expression than genetically engineered mouse models (GEMM), and primary culturing of GEMM-derived metastatic tissue induced mesenchymal-like gene expression. In addition, metastasis-specific transcriptomes differed between tail vein and orthotopic injection of the same cell line. Gene expression common to models of spontaneous metastasis included sildenafil response and nicotine degradation pathways. Strikingly, in vivo sildenafil treatment significantly reduced metastasis by 54%, while nicotine significantly increased metastasis by 46%. These data suggest that (i) actionable metastasis-specific pathways can be readily identified, (ii) already available drugs may have great potential to alleviate metastatic incidence, and (iii) metastasis may be influenced greatly by lifestyle choices such as the choice to consume nicotine products. In summary, while mouse models of breast cancer metastasis vary in ways that must not be ignored, there are shared features that can be identified and potentially targeted therapeutically. Implications: The data we present here exposes critical variances between preclinical models of metastatic breast cancer and identifies targetable pathways integral to metastatic spread. Visual Overview: http://mcr.aacrjournals. org/content/molcanres/18/9/1278/F1.large. jpg. Visual Overview
Composition and Diversity of Soil Bacterial Communities along an Environmental Gradient in the Sudano-Sahelian Region of Senegal

The soils of the semi-arid Sudano-Sahelian region of West Africa have been identified as being highly vulnerable to soil degradation with impacts on their capacity to provide goods and services in which soil microorganisms participate. Unfortunately, soil microbial diversity from this semi-arid region with high rainfall variability remains largely unexplored. The aim of the present study was to characterize the diversity and composition of the soil bacterial communities and to identify factors involved in their spatial distribution along an environmental gradient in Senegal. Samples were collected from non-anthropogenic sites across four pedoclimatic zones. Bacterial communities were characterized using next-generation sequencing and soil physico-chemical parameters were determined. Our results showed that Firmicutes, Actinobacteria, Proteobacteria, Chloroflexi, Gemmatimonadetes, Acidobacteria, and Verrucomicrobia phyla were predominant in the soils of the region. Bacterial α-diversity was stable along the environmental gradient whereas β-diversity highlighted significant changes in the composition of the soil bacterial community. Changes were driven by shifts in the relative abundance of OTUs belonging mainly to the genus Bacillus, Conexibacter, Kaistobacter, Solirubrobacter, Ktedonobacter, Sphingomonas, Microvirga, Rubrobacter and Pelobacter. Soil properties like pH, soil moisture and clay content were the environmental parameters identified as drivers of the composition of the bacterial communities in the semi-arid Sudano-Sahelian region of Senegal (West Africa).
'Nihon E Yokoso': An Inter-Prefectural Analysis of the Japanese Tourism Sector and Its Economic Spillovers

This study aims to estimate the spillover effects resulting from a remarkable increase in tourism flows in Japan, and to investigate the impact of territorial resources on regional economic growth. Main results confirm the existence of both economic and tourism spillover effects; more precisely, two spatial econometric models suggest the importance of infrastructure networks, natural parks and museums. Furthermore, in contrast with prior studies, a positive correlation between economic growth and the endowment in natural resources is found. Lastly, for the first time in this kind of researches, international conferences are shown to have a positive impact on tourists stays. However, efforts for reinvigorating economy through tourism development and investment deserve a careful evaluation: although an overall increase of tourists, lights and shadows are found at territorial level, inter alia an overwhelming concentration of travellers in the widely known destinations.
Traditional Meals and Sense of At-Homeness – Finnish Immigrants with Dementia in Bilingual Residential Care in Sweden

For immigrants with dementia the language learnt last is lost first, and then gradually the native language. When dementia has reached its advanced stages, professional care is needed. The transition to a dementia care unit may be a challenge for a person from another cultural background than in the hosting country. In a few cities, care is offered in ethnic settings with bilingual nursing staff and other cultural features familiar to the residents. One cultural aspect is related to meals and the aim of this study was to explore the food-culture in a Finnish-speaking care unit for Finnish-speaking immigrants with dementia in Sweden from the perspectives of bilingual nursing staff and family members. Method: A qualitative design was chosen to understand personal experiences of the care provided to Finnish immigrants with dementia. The 18 participants, caregivers and family members were chosen by purposive sampling. The interviews were based on semi-structured questions and data was analyzed using qualitative content analysis. Two main categories: meals stimulating the appetite and meals as a cultural reminder with respective sub-categories emerged. Findings: Being served traditional meals were important for physical as well as psychological reasons. Finnish dishes that the older persons with dementia recognized and liked, stimulated the appetite and contributed to keep the Finnish residents in good health. Traditional meals were considered triggering the residents´ memories and when celebrating cultural holidays, Finnish dishes were a reminder of the residents´ cultural identity and one of the aspects contributing to a feeling of belonging and at-homeness.