Miracle-dz/UniFAR-FTUs huggingface dataset:
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REFERENCES 1. Li Y, Zhou H, Liu M, Liang M, Wang G, Wang B, et al. Association of visit-to-visit variability in blood pressure and first stroke risk in hypertensive patients with chronic kidney disease. J Hypertens 2020; 38:610– 617. 2. Angeli F, Reboldi G, Verdecchia P. Blood pressure variability and risk of stroke in chronic kidney disease. J Hypertens 2020; 38:599–602. 3. Joukar F, Naghipour MR, Yeganeh S, Sepehrimanesh M, Keshtkar A, Ashoobi MT, et al. Validity and inter-observers reliability of blood pressure measurements using mercury sphygmomanometer in the PERSIAN Guilan Cohort Study. Blood Press Monit 2020; 25:100–104. 4. Visaria A, Amorosa L. Measurement-to-measurement blood pressure variability as a predictor of cardiovascular disease outcomes. J Am Coll Cardiol 2020; 75 (11 Suppl 1):1947. 5. Zhao MX, Zhao Q, Zheng M, Liu T, Li Y, Wang M, et al. Effect of resting heart rate on the risk of all-cause death in Chinese patients with hypertension: analysis of the Kailuan follow-up study. BMJ Open 2020; 10:e032699. 6. Woodward M, Webster R, Murakami Y, Barzi F, Lam TH, Fang X, et al. The association between resting heart rate, cardiovascular disease and mortality: evidence from 112,680 men and women in 12 cohorts. Eur J Prev Cardiol 2014; 21:719–726. 7. Webb AJ, Fischer U, Mehta Z, Rothwell PM. Effects of antihypertensivedrug class on interindividual variation in blood pressure and risk of stroke: a systematic review and meta-analysis. Lancet 2010; 375:906– 915. 8. Papaioannou TG, Protogerou AD, Stamatelopoulos KS, Alexandraki KI, Vrachatis D, Argyris A, et al. A cohort-based comprehensive characterization of different patterns of very short-term, within-visit, blood pressure variability. Blood Press Monit 2020; [Epub ahead of print] doi: 10.1097/MBP.0000000000000435. 9. Lee SR, Choi YJ, Choi EK, Han KD, Lee E, Cha MJ, et al. Blood pressure variability and incidence of new-onset atrial fibrillation: a nationwide population-based study. Hypertension 2020; 75:309–315. 10. Wohlfahrt P, Cı́fková R, Krajcoviechová A, Šulc P, Bruthans J, Linhart A, et al. Comparison of three office blood pressure measurement techniques and their effect on hypertension prevalence in the general population. J Hypertens 2020; 38:656–662.
Influence of milk, corn starch, and baking conditions on the starch digestibility, gelatinization, and fracture stress of biscuits

ABSTRACT Dough for nontraditional semisweet biscuits—prepared with wheat flour or replacing part of the wheat flour with corn starch, with or without skim milk—was baked at two oven temperatures, 120 or 170°C, until reaching moisture content and water activity lower than 6% and 0.5, respectively. Assays of fracture stress, differential scanning calorimetry, X-ray diffraction, and starch digestibility were performed. Results showed that biscuits containing milk had the highest fracture stress, and biscuits baked at low temperature were harder than biscuits baked at high temperature. The degree of starch gelatinization during baking was higher when dough was baked at 170°C, compared with dough baked at 120°C. The decrease in gelatinization coincides with the decrease in the height and surface of peaks at 15 and 23° in the X-ray diffraction patterns. Milk and corn starch did not affect the starch digestibility of biscuits, but biscuits baked at 170°C presented lower fracture stress and higher starch digestib.
Leishmania donovani Infection with Atypical Cutaneous Manifestations, Himachal Pradesh, India, 2014–2018

We conducted a molecular study of parasite sequences from a cohort of cutaneous leishmaniasis patients in Himachal Pradesh, India. Results revealed atypical cutaneous disease caused by Leishmania donovani parasites. L. donovani variants causing cutaneous manifestations in this region are different from those causing visceral leishmaniasis in northeastern India.
Disrupted function of lactate transporter MCT1, but not MCT4, in Schwann cells affects the maintenance of motor end‐plate innervation

Recent studies in neuron‐glial metabolic coupling have shown that, in the CNS, astrocytes and oligodendrocytes support neurons with energy‐rich lactate/pyruvate via monocarboxylate transporters (MCTs). The presence of such transporters in the PNS, in both Schwann cells and neurons, has prompted us to question if a similar interaction may be present. Here we describe the generation and characterization of conditional knockout mouse models where MCT1 or MCT4 is specifically deleted in Schwann cells (named MCT1 and MCT4 cKO). We show that MCT1 cKO and MCT4 cKO mice develop normally and that myelin in the PNS is preserved. However, MCT1 expressed by Schwann cells is necessary for long‐term maintenance of motor end‐plate integrity as revealed by disrupted neuromuscular innervation in mutant mice, while MCT4 appears largely dispensable for the support of motor neurons. Concomitant to detected structural alterations, lumbar motor neurons from MCT1 cKO mice show transcriptional changes affecting cytoskeletal components, transcriptional regulators, and mitochondria related transcripts, among others. Together, our data indicate that MCT1 plays a role in Schwann cell‐mediated maintenance of motor end‐plate innervation thus providing further insight into the emerging picture of the biology of the axon‐glia metabolic crosstalk.
Agreeing to disagree: reports of the popularity of Covid-19 conspiracy theories are greatly exaggerated

A study recently published in this journal showed that agreement with conspiracy theories about the Covid-19 pandemic is associated with risky, non-compliant behaviours (Freeman et al., 2020a). It also indicated that this agreement is very common: 45% of British participants seemed to agree that Covid-19 is a bioweapon designed by China to destroy the West, while 20% seemed to agree that the pandemic is a conspiracy by Jews or Muslims. Accurate or not, these statistics paint a worrying picture. If accurate, millions of British people need to be disabused of wild con-spiracy theories. If inaccurate, especially if they exaggerate the popularity of conspiracy theories, they could normalise Antisemitic, Islamaphobic, and conspiracist viewpoints (McManus, D ’ Ardenne, & Wessely, 2020), and misdirect policy, interventions, and further research. McManus et al. (2020) pointed out that Freeman et al. ’ s (2020a) study indeed runs these risks, because of a response scale that gave participants four options to agree (from ‘ agree a little ’ to ‘ agree
Detritus and Juvenile Salmon Production in the Nanaimo Estuary: II. Meiofauna Available as Food to Juvenile Chum Salmon (Oncorhynchus keta)

The meiofauna of the Nanaimo Estuary are briefly described. Nematodes and harpacticoid copepods were the numerically dominant taxa and reached their maximum population densities in late summer. Harpacticus uniremis was very important to the early diet of juvenile chum salmon (Oncorhynchus keta) but was one of the least common harpacticoid copepods in the estuary. The productivity of H. uniremis was found to be only slightly greater than the calculated food requirement of the chum salmon fry; there was close coupling between prey and predator. The role of detritus and bacterially processed carbon in the feeding of H. uniremis are discussed. Key words: harpacticoid copepods, secondary production, detritus, Harpacticus uniremis, turnover ratios, meiofauna
Engineering the Phases and Heterostructures of Ultrathin Hybrid Perovskite Nanosheets

Low‐dimensional perovskites have gained increasing attention recently, and engineering their material phases, structural patterning and interfacial properties is crucial for future perovskite‐based applications. Here a phase and heterostructure engineering on ultrathin perovskites, through the reversible cation exchange of hybrid perovskites and efficient surface functionalization of low‐dimensional materials, is demonstrated. Using PbI2 as precursor and template, perovskite nanosheets of varying thickness and hexagonal shape on diverse substrates is obtained. Multiple phases, such as PbI2, MAPbI3 and FAPbI3, can be flexibly designed and transformed as a single nanosheet. A perovskite nanosheet can be patterned using masks made of 2D materials, fabricating lateral heterostructures of perovskite and PbI2. Perovskite‐based vertical heterostructures show strong interfacial coupling with 2D materials. As a demonstration, monolayer MoS2/MAPbI3 stacks give a type‐II heterojunction. The ability to combine the optically efficient perovskites with versatile 2D materials creates possibilities for new designs and functionalities.
The Functional Morphology and Interpretation of the Insect Ovipositor

Elsewhere (Scudder, 1957a), I have outlined briefly a revised interpretation of some basal structures in the insect ovipositor. It was shown that in insects other than the Machilidae, the female genitalia has a common plan, this plan differing from that usually taken as the basic type. Whilst Snodgrass (1933) based his interpretations of all the higher orders on the condition in Machilidae, I have shown that a more satisfactory interpretation is obtained if the condition in the tepismidae is taken as the basic tvpe.
Higher training workloads do not correspond to the best performances of elite basketball players

ABSTRACT The aim of this study was to identify the correspondence between the workload demands in training sessions and the game performance from elite basketball players, according to their specific positions. Data were collected from a professional men’s basketball team competing in the Spanish Professional League and Euroleague. Players’ activity during the training sessions was measured using WIMU PRO® and the game statistics were used as a measure of game performance. Cluster analysis allowed to classify the training workload and the game performance, whereas correspondence analysis allowed to explore their relationship. In essence, there was no correspondence from the higher workloads with the best performances, on the contrary, the small forwards’ best performances corresponded to lower training workouts. Despite their importance, the external measures of load need to be complemented with additional (and valid) measures that can be translated to game performance.
INSIGHTS ON AROMATASE IMMUNOHISTOCHEMISTRY: VARIATIONS BETWEEN INTRINSIC MOLECULAR SUBTYPES OF BREAST CANCERS.

Context Aromatase is a key enzyme in local estrogen production by androgen conversion, especially in women post-menopause. There have been controversies concerning aromatase localization in breast carcinomas and its association with current histopathological variables. Material and Methods Using polyclonal antibody immunohistochemistry we assessed (by intensity and percentage scores) the immunolocalization of aromatase in 70 tissue samples, and described particularities within the molecular subtypes of breast cancer. Results Aromatase was found in all tissue compartments: tumor (95.7%), stroma (58.6%) and adipose tissue (94.3%). Aromatase expression in tumor cells correlated inversely with tumor grading (p=-0.361, p=0.027), and positively with estrogen receptor status (ER, p=0.143, p<0.001). Dividing the study group by intrinsic subtypes, a strongly inversely association between tumor aromatase and grading (p=-0.486, p<0.001), and between stromal aromatase and Ki67-index (p=-0.448, p=0.048) was observed in luminal A breast cancer. Tumor aromatase and ER percentage scores had stronger correlations in luminal B HER2 negative (p=0.632, p=0.002), and positive (p=0.324, p=0.026) tumors. In contrast, in triple negative tumors, a positive association stromal aromatase and Ki67 index (p=-0.359, p=0.007) was observed. Conclusion Local aromatase was linked to better tumor differentiation and proliferation in luminal breast subtypes, and not in triple negative cases, suggesting a potential prognostic role of aromatase in breast carcinomas.
Collaboration applications for mixed home care — A systematic review of evaluations and outcomes

Objectives Mixed home care, in which informal and professional actors work closely together, contributes significantly to ensuring home care up to old age. In this context, collaboration applications can considerably enhance the interactions among caregivers. However, although much research is conducted on need and requirement analyses of such applications, little is known about their introduction and use in care models. The purpose of this contribution is to identify studies that evaluate collaboration applications for mixed home care and compare their outcomes. Methods To identify literature on mixed home care collaboration applications (mHCA) and their evaluation, a systematic literature review was conducted in five bibliographic databases covering the years 2008 through 2019. The results were supplemented by a search in the meta-database Google Scholar. The evaluation approaches of the studies were analyzed and results compared by using the NASSS framework. Finally, a context concretized model was derived which summarizes interrelations. Results Twelve qualitative studies evaluating eleven applications could be identified. They report on increased competency in self-management, psychological relatedness, involvement, and understanding. However, most studies conclude that large scale platform tests are still needed to prove significant changes in care processes, communication, or organization. Conclusion Among other things, their implementation is rather difficult due to the specifics of the target group. To enable a more targeted and successful implementation, it might be helpful to classify care networks beforehand and assess their communication behavior and needs. To prove the added value of mHCAs standardized assessment tools should be used.
Adipokinetic hormone enhances CarE‐mediated chlorpyrifos resistance in the brown planthopper, Nilaparvata lugens

Adipokinetic hormone (AKH), the principal stress‐responsive neurohormone in insects, has been implicated in insect responses to insecticides. However, the functionality of AKH and its mode of signalling in insecticide resistance are unknown. Herein, we demonstrated that the enhanced activity of carboxylesterases (CarEs) is involved in the chlorpyrifos resistance in Nilaparvata lugens [brown planthopper (BPH)]. Chlorpyrifos exposure significantly induced the expression of AKH and its receptor AKHR in the susceptible BPH (Sus), and these two AKH signalling genes were over‐expressed in the chlorpyrifos‐resistant strain (Res) compared to Sus. RNA interference (RNAi) against AKH or AKHR decreased the CarE activity and suppressed the BPH's resistance to chlorpyrifos in Res. Conversely, AKH peptide injection elevated the CarE activity and enhanced the BPH's survival against chlorpyrifos in Sus. Furthermore, five CarE genes were identified to be positively affected by the AKH pathway using RNAi and AKH injection. Among these CarE genes, CarE and Esterase E4‐1 were found to be over‐expressed in Res compared to Sus, and knockdown of either gene decreased the BPH's resistance to chlorpyrifos. In conclusion, AKH plays a role in enhancing chlorpyrifos resistance in the BPH through positive influence on the expression of CarE genes and CarE enzyme activity.
Lactoferrin Concentration in Buffalo Milk

The objective of this study was to quantify lactoferrin (Lfe) in buffalo milk and to examine the factors affecting milk Lfe, such as the lactation stage, daily milk yield, parity, and milk somatic cells count (SCC). Milk Lfe concentration was detected by the SDS-polyacrilamide gel electrophoresis (SDS-PAGE). The overall mean of Lfe concentration was 0.332±0.165 g/kg and ranged from 0.030 to 0.813 g/kg. Milk Lfe concentrations increased (P<0.01) with the increase of days in milk, but it was not affected by parity. Milk Lfe concentration was significantly affected by SCC. The differences became significant when the levels of SCC increased up to 200,000/mL. This is the first investigation on the levels of Lfe in buffalo milk in reference to daily milk production, lactation stage, parity and SCC. Further studies are needed to clarify the relationship between Lfe and SCC in buffalo milk.
The ototoxic potential of cobalt from metal-on-metal hip implants: a pilot study on the patient-reported auditory, vestibular, and general neurological outcome

Abstract Objective This study aimed to systematically investigate the ototoxic potential of cobalt in patients with a metal-on-metal (MoM) hip implant, using objective auditory and vestibular assessments and a questionnaire. The results of the objective evaluation were published previously, whereas the current study focused on the questionnaire outcome and its relationship to the blood cobalt level. Design and study sample: Twenty patients (33–65 years) with a primary MoM hip implant and 20 non-implanted control subjects, matched for age, gender, and noise exposure, received a questionnaire to evaluate the presence of several hearing and balance symptoms (part 1) and general neurological issues (part 2). Results Concerning part 1, the proportion of auditory-related symptoms in general (p = 0.022) and tinnitus (p = 0.047) was significantly higher in the MoM patient group, whereas no group difference was found for hyperacusis, increased listening effort, and decreased speech understanding. Concerning part 2, no significant group differences were detected. Within the MoM patient group, the questionnaire outcome was not significantly different between the low-exposure and high-exposure subgroups according to the blood Co level. Conclusions In line with our previous study, these results potentially imply Co-induced impairment to the auditory system, despite the lack of a clear dose–response relationship.
Inappropriate combination therapy in hypertension.

G lobally, arterial hypertension is the major cause of cardiovascular mortality and morbidity [1]. Nonpharmacologic interventions have limited effect on blood pressure (BP). Efficacy and safety of pharmacological treatment of hypertension are therefore of vital importance. The effect on total and cardiovascular mortality and morbidity of antihypertensive medicines have been abundantly documented in numerous studies and meta-analyses. Overall, the effect is dependent on the level of BP: the higher the BP, the more pronounced effect on mortality and morbidity [2,3]. Four major classes of antihypertensive medicines angiotensin-converting enzyme inhibitors and angiotensin II receptor antagonists, beta blockers, Ca-antagonists and diuretics) have significant effect on BP as well as documented effect on cardiovascular outcomes [4]. Single drug treatment fails to control BP in many cases, and up to 67% of the patients may in fact be candidates for combination therapy [5,6]. Not all classes of medicines can be safely combined, for a variety of reasons, for example safety and lack of efficiency. Furthermore, combination of drugs in the same class is redundant and should as a rule be avoided. Due to the high number of patients in need of combination therapy, there are significant possibilities for inappropriate combinations. As reported in this issue of the Journal, Falster et al. [6] studied the occurrence of inappropriate combinations in Australia by scrutinizing a random sample of patients in the national prescription register for antihypertensive medications. A total of 425 541 patients were registered as recipients of antihypertensive medication, about 50% on a single agent, 32% on two agents and the rest on three or more agents. The occurrence of inappropriate combinations overall was 2.4%, with the majority (1.5%) treated against guidelines and 0.9% receiving within-class polytherapy. Patients receiving fixed-dose combinations were less exposed than patients on free combinations. The authors estimate that
Parthenium hysterophorus mediated inflammation and hyper‐responsiveness via NF‐κB pathway in human A549 lung cancer cell line

Being one of the notorious weed P. hysterophorus has invaded almost every part India and is the lead cause of skin allergies and severe dermatitis among farmers and rural population. It is an invasive obnoxious weed capable of surviving extreme environmental conditions and various parts of this plant are reported to cause severe contact allergies in humans due to the presence of high concentrations of toxic sesquiterpene lactones viz. parthenin. It can stimulate numerous cellular and immune responses that may translate into Oxidative stress, allergies, and inflammation. The effect of P. hysterophorus flower extract was evaluated on cell viability, oxidative stress and inflammation in A549 lung cancer cell line by spectrophotometric and reverse transcriptase‐polymerase chain reaction methods. Schrodinger software based docking was performed for possible interactions studies. The A549 cells treated with P. hysterophorus flower extract favors increase in cell viability, reactive oxygen species generation. The mRNA expression of proinflammatory cytokines such as IFN‐γ, TNF‐α, and IL‐1β was significantly increased whereas no change in IL‐18 expression was observed. Significant increase in protein expression of NF‐κB was observed, suggesting the role of NF‐κB signalling in allergic responses. The docking studies demonstrated the potential interaction between Parthenin and NF‐κB/IL‐1β/IL‐18 suggesting their activation leading to inflammation. The current study emphasize that P. hysterophorus mediates oxidative stress, and inflammatory process via alterations in expression of proinflammatory cytokines such as IL‐1β, IFN‐γ through NF‐κB activation which was also confirmed in docking studies. Cellular and molecular mechanisms involved in pathogenesis of allergic/chronic inflammation and severe dermatitis need to be further investigated to identify specific binding partners responsible for severe inflammation which can provide some leads in developing effective targets against severe dermatitis and skin allergies.