Miracle-dz/UniFAR-FTUs huggingface dataset:
The Positive Impact of Educational Intervention Program Based on Precede Model on Preventive Behaviors to Reduce Brucellosis in the Rural People of Khomein

Background and Objective : Brucellosis is a zonosis that can be transmitted between species from animals to humans or from humans to animals, which is still a major health and economic problem. The main preventive strategy for brucellosis is to educate rural ranchers on the basis of Precede framework. We aimed to study the effect of educational intervention program based on Precede Model and its main components on preventive behaviors to reduce Brucellosis in the rural district of Khomein. Material and Methods : In this pre-experimental randomized controlled study, the samples were 400 adult men of rural district of Khomein city randomly allocated to case and control groups. Data gathering instrument was a questionnaire based on Precede framework. Reliability of the questionnaire through the internal consistency test on the pilot phase was approved on 25 individual and the validity was confirmed by face validity. The intervention, based Precede framework, was a package of three 60-90 minute sessions conducted weekly. The subjects were followed for three months and the data analyzed by independent T-test, paired T-test, analysis variance with repeated observations. Results: After intervention, the mean scores of predisposing(knowledge and attitude), reinforcing and enabling factors in case group is different significantly from that in control group (p<0.05). Conclusion: Planning and implementation of health education intervention via Precede framework could be positive in increasing preventive behaviors to reduce brucellosis incidence.
Antioxidant Vitamins and Body Mass Index in Adolescents

Antioxidants have been shown to have protective effects against inflammation and oxidative stress, also healthy body weight is an important indicator towards prevention of diseases. This study was carried out to report the odds of low antioxidants vitamins (A, E and C) in underweight, normal and overweight adolescents. Dietary assessment was conducted using 24 hour dietary recall and biochemical assay of vitamin A, E and C were carried out using a High Performance Liquid Chromatography (HPLC). Our findings revealed the overall energy intake (EI) to be higher (p<0.05) among male (2014.4±194.6kcal) than their female (1441.1±169.3kcal) counterparts. Mean antioxidant vitamins A (15.55±6.14 vs 15.74±6.33µg/dl), E (253.48±25.99 vs 251.69±25.35µg/dl) and C (5.00±2.41 vs 4.80±2.28 µg/dl) for female and male subjects showed significant difference (p<0.05). Age and BMI have weak associations (r = 0.18, p<0.05) with vitamin A, E & C status. Moderate and severe deficiency of antioxidant vitamins exist among our study population irrespective of their age groups. This deficiency is of public health importance. Therefore, there is urgent need for public enlightenment and provision of supplements to avert the scourges of vitamins deficiency.
External Connection versus Internal Connection in Dental Implantology. A Mechanical in vitro Study

(1) Background: In today's dentistry, implantology has become a therapeutic resource of choice in certain clinical situations. The design of implants has evolved in several aspects since their inception. Dental implants were initially designed with an external hex connection, although due to force transmission and security in the adjustment of the prosthesis, later implants featured an internal hex connection. This study aims to analyse the mechanical properties of two types of implants (an internal connection and an external connection) from the same manufacturer and their different prosthetic components (union screw between implant and prosthetic abutment, and the abutment itself) when subjected to different types of load. (2) Materials and methods: Intraosseous dental implants of similar shape, design and size, although different in type of connection (external vs. internal), were studied. The specifications of the UNI EN ISO 14801 test standard were used, with all determinations being carried out three times. Finally, the dimensional characterisation of the samples analysed after the dynamic load study was carried out, and the values of both study groups were compared by means of the non-parametric Mann–Whitney U test to find statistically significant differences (p < 0.05). (3) Results: For the static characterisation test, we found between 610.9 N and 986.1 N for the external connection and between 1263.6 N and 1324 N for the internal connection (p = 0.011). All of the dynamic load tests were positive and there was no failure in any of the components studied. (4) Conclusions: After the analysis of the samples studied in vitro, satisfactory results were obtained, demonstrating that both connections can support considerable mechanical loads according to international standards (UNI EN ISO 14801).
Carfilzomib, Rituximab and Dexamethasone (CaRD) Is Highly Active and Offers a Neuropathy Sparing Approach For Proteasome-Inhibitor Based Therapy In Waldenstrom’s Macroglobulinemia

Bortezomib frequently produces severe treatment-related peripheral-neuropathy in Waldenstrom9s Macroglobulinemia (WM). Carfilzomib is a neuropathy-sparing proteasome-inhibitor. We examined carfilzomib, rituximab, and dexamethasone (CaRD) in symptomatic WM patients naive to bortezomib and rituximab. Protocol therapy consisted of IV carfilzomib 20 mg/m 2 (cycle 1), 36 mg/m 2 (cycles 2-6) with IV dexamethasone 20 mg on days 1,2,8,9 and rituximab 375 mg/m 2 on days 2,9 every 21-days. Maintenance-therapy followed 8-weeks later with IV carfilzomib 36 mg/m 2 and IV dexamethasone 20 mg on days 1,2 and rituximab 375 mg/m 2 on day 2 every 8-weeks for 8-cycles. Post-therapy, median serum IgM levels declined from 3,375 to 749 mg/dL (p L265P or CXCR4 WHIM mutation status. With a median follow-up of 15.4 months, 20 patients remain progression-free, including 8 on maintenance-therapy. Grade >2 toxicities included asymptomatic hyperlipasemia (41.9%), reversible neutropenia (12.9%), and cardiomyopathy in one patient (3.2%) with multiple risk factors. Declines in serum IgA and IgG were common. CaRD offers a neuropathy-sparing approach for proteasome-inhibitor based therapy in WM. Study registered at www.clinicaltrials. gov (NCT01470196).
Diagnostic value of neutrophil to lymphocyte ratio, platelet to lymphocyte ratio and mean thrombocyte volume in irritable bowel syndrome-constipation according to rome IV criteria

Aim: Structural and biochemical reagents that could help diagnose irritable bowel syndrome (IBS) are still lacking. Moreover, use of certain diagnosis criteria in the diagnosis of the disease decreases the need for making over-diagnostic tests in order to rule out other diseases. Rome IV criteria include new parameters for the diagnosis of IBS. Our objective in this study is to research the diagnostic value of neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR) and mean platelet volume (MPV) count in IBS-Constipation (IBS-C). Material and Methods: Data of the cases among patients who applied to general surgery polyclinics of Ordu University Medical Faculty who were diagnosed with IBS and have Rome IV IBS-C diagnosis criteria. Healthy volunteers were selected from adult healthy patients who applied to general surgery policlinics of our hospital for general health check purposes. The age, sex, WBC (white blood cell), NLR, PLR, MPV values of the cases were analyzed. Results:Average age of IBS-C group was 39.47±9.97 (min 19-max 57). Average age of the control group was 40.16±11.50 (min 18max 59). Out of 78 IBS-C group patients, 48 (61.5%) were women and 30 (38.5%) were men. Of 82 patients 54 (65.9%) were women, 28 (%34.1) were men. Average age of the patients was 39.83±10.75 (min 18-max 59). A significant result was obtained for NLR when control group was compared with IBS-C group (p=0.01). No significant difference was determined between two groups for MPV, PLR (p>0.05). Cut-off value of NLR was calculated as 1.895, and the sensitivity in IBS diagnosis was calculated as 51.3%, and the specificity was calculated as 59.8%. Conclusion: We have determined significant results with NLR, which is an inflammatory reagent, in IBS-C according to Rome IV Criteria. However, NLR has low sensitivity and specificity for IBS-C diagnosis from the other causes of constipation. We are of the opinion that inflammatory reagents such as NLR, PLR, MPV are not useful in the diagnosis of this disease. We consider that our study will shed a light on future studies with larger research populations.
Supportive Psychotherapy for Enhancing Quality of Life among Patients with Depression

Major depressive disorder is the second leading disease causing functional impairment and disability. It is a prevalent health problem which is associated with diminished life quality, and significant physical and psychosocial impairment. Therefore, the current study aimed to enhance quality of life and decrease depressive symptoms for patients with depression through utilization of supportive psychotherapy. This study was conducted on 40 patients during their follow-up visits to the Outpatient Clinic, Al-Abbassia Mental Health Hospital. Data were collected using: 1) Interviewing questionnaire sheet including, socio-demographic data, history of depression and the patient's knowledge regarding depression. 2) Beck's Depression Inventory. 3) World Health Organization Quality of life Scale. The main result of this study showed that, there is a highly statistically significant difference between pre-post program implementation as regards patients knowledge about depression, level of depression and their total score of quality life domains. The study concluded that, utilization of supportive psychotherapy showed great enhancement of quality of life and decrease in depressive symptoms among patients with depression. The study recommended that the concept of supportive psychotherapy and quality of life should be integrated in nursing education curriculum to help nursing staff to guide patients with depression and their families on how to avoid and/or cope with depression to maintain normal life style at highest possible level of quality of life.
Effect of Weight Loss and Lifestyle Changes on Vascular Inflammatory Markers in Obese Women

THE RATE OF OBESITY AND THE numbers of dieters are increasing in parallel. More than 54 million Americans are currently dieting, yet the epidemic of obesity continues virtually unabated with no sign of reversal. Obesity is an independent risk factor for cardiovascular disease. Adipocytes synthesize and secrete several cytokines, including tumor necrosis factor , interleukin 6 (IL-6), and adiponectin, the latter being one of the most abundant adipose tissue–specific adipocytokines. Elevated levels of several proinflammatory cytokines, such as IL-6, IL-18, and tumor necrosis factor , as well as the sensitive marker of inflammation C-reactive protein (CRP), have been found associated with proxy indicators of elevated body fat (body weight and body mass index [BMI], calculated as weight in kilograms divided by the square of height in meters) and with cardiovascular disease risk factors. Moreover, several proinflammatory molecules, including CRP, IL-6, and IL-18, have been prospectively associated with thrombotic cardiovascular events. For the present study in obese women, we measured the serum concentrations of IL-6, IL-18, and CRP, as well as adiponectin, the novel adipocytokine with anti-inflammatory and insulinsensitizing properties, and their rela-
Caseous lymphadenitis (Pseudotuberculosis) in camelids

Corynebacteria are pyogenic bacteria causing a variety of suppurative diseases. The virulence of Corynebacteriumpseudotuberculosis is attributed to the haemolytic toxin which possesses phospholipase activity and to cell wall lipids. The pathogen causes pseudotuberculosis or lymphadenitis in sheep, goats and camelids, but it is rare in other animal species. The infection is spread via ingestion, inhalation or wounds, and pathognomic for the disease are cold, closed painless abscesses up to the size of a lemon or orange in external lymph nodes especially at the base of the neck and in prescapular lymph nodes. Corynebacteria are sensitive to several antibiotics but the abscess prevents the medication from reaching the bacteria. It is therefore recommended to perform both, surgical and antibiotic treatment. Commercial vaccines are available for sheep and goats, but have not been evaluated for camelids. These vaccines do not provide complete protection against the development of abscesses but a significant reduction in the number of abscesses. After mange Caseous lymphadenitis (CLA) remains the most important skin disease of camelids.
Parameters of immune and antioxidative systems can be considered as surgical stress markers for gastric cancer patients

Cytokines, haematological indices, lipid peroxidation product and antioxidative system parameters were investigated for surgically treated and red blood cells transfused stages 3 and 4 gastric cancer patients. Serum of 58 patients was analysed at pre-surgical and post-surgical periods (after 7 and 14 days). TGF-beta1 and TNF-alpha were tested by ELISA. Haematological indices were analyzed by standard methods. Malondialdehyde level and antioxidative system parameters were analysed by specified methods spectrophotometrically. Level of TGF-beta1 increased and lymphocyte index decreased after surgery and the transfusion for both stages cancer patients. Level of malondialdehyde decreased at early post-surgical period for non-transfused both stages cancer patients while the parameter decreased only at late post-surgical period for transfused patients. Total glutathione concentration decreased during post-surgical period only for transfused stage 3 cancer patients. Pearson correlations were determined between cytokine and malondialdehyde levels and between cytokine levels and activities of catalase and glutathione S-transferase at early post-surgical period. Decreased lymphocyte count, increased TGF-beta1 level and lower total glutathione concentration after surgery were related to red blood cells transfusion. Malondialdehyde level was not significantly influenced by gastric cancer stage while it was also affected by the transfusion. All altered parameters mentioned showed the additional transfusion-dependant stress to develop surgical stress. The parameters can be considered as possible surgical stress markers.
Changes in serum cortisol and some innate immunity parameters after exhaustive exercise in male dogs

The aim of the present study was to investigate the influence of exhaustive exercise on some innate immunity parameters and cortisol levels. Twelve male, mongrel dogs were divided into an experimental group, submitted to prolonged, strenuous exercise with exhaustion as the end-point, and a control group without any exposure to exercise. Serum cortisol levels were measured before exercise (BE), right after (0 h) and on 2nd hour and 4th hour after exercise. The neutrophil function (phagocytosis, phagocytic index, hydrogen peroxide production-H2O2) and classical pathway of complement activation (CPCA) were measured as followеd: BE, right after exercise and on 2, 4, 24, 48, 72 h, and 7, 14 day after exercise. In experimental animals cortisol decreased on hour 4 after exercise (P<0.05), compared to BE level, and on hour 2, compared to controls (P<0.05). Percentage of H2O2 producing neutrophils in experimental animals dropped significantly on hour 4 and day 7 after exercise (P<0.05), compared to BE level and on hour 4 (P<0.01) vs control group. Percentage of phago-cytising neutrophils decreased slightly on hour 48 (P<0.05), compared to BE level. Phagocytic index and CPCA had an insignificant increase after exercise. Inappropriate changes in cortisol levels could indicate inadequate adaptive response to exercise. Overtraining could make animals more susceptible to infection.
Estimation Body Height according to Tibia Length in Children with Cerebral Palsy Aged 6-12 Years in Bandung, Indonesia

Background and Objective. Children with Cerebral Palsy (CP) have a risk of contracture or hypotonia causing difficulty in measuring their standardized height hence it requires height estimation based on the tibial length as an alternative measurement. Estimation body height formula is not available yet in Indonesia. We aim to determine the estimation body height according to tibia length in children with cerebral palsy aged 6-12 years in Bandung, Indonesia. Methods. The subjects are children 6-12 years old with CP who attended Special School, Growth and Development Clinic, Neuropediatric, and Medical Rehabilitation Outpatient Department at Hasan Sadikin General Hospital in Bandung, Indonesia between March until May 2019. This research performed a cross-sectional study. The height, body length, and tibia length of subjects who met the inclusion criteria were measured concomitantly. Data analysis was performed using linear regression. Results. We found 68 CP patients who met the inclusion criterion. Patients could be measured using the standard method are 36 children which then analyzed statistically. There were 36 subjects consisting of 22 boys (61,1%) and 14 girls (38,9%). The new calculation formula for body height estimation based on the tibia length in CP children aged 6-12 years is = 32,01 + 2,90 * tibia length (Standard error of the estimate ±1,85). Conclusion. Measurement of tibia length is important in determining the height estimation in children with CP so growth could still be monitored in the patients. There is a new calculation formula that we can use for height estimation based on the tibial length in children with CP aged 6-12 years.
Establishment and validation of an immunodiagnostic model for prediction of breast cancer

ABSTRACT Serum autoantibodies that react with tumor-associated antigens (TAAs) can be used as potential biomarkers for diagnosis of cancer. This study aims to evaluate the immunodiagnostic value of 11 anti-TAAs autoantibodies for detection of breast cancer (BC) and establish a diagnostic model for distinguishing BC from normal human controls (NHC) and benign breast diseases (BBD). Sera from 10 BC patients and 10 NHC were used to detect 11 anti-TAAs autoantibodies by western blotting. The 11 anti-TAAs autoantibodies were further assessed in 983 sera by relative quantitative enzyme-linked immunosorbent assay (ELISA). Binary logistic regression and Fisher linear discriminant analysis were conducted to establish a prediction model by using 184 BC and 184 NHC (training cohort, n = 568) and validated by leave-one-out cross-validation. Logistic regression model was selected to establish the prediction model. Results were validated using an independent validation cohort (n = 415). The five anti-TAAs (p53, cyclinB1, p16, p62, 14-3-3ξ) autoantibodies were selected to construct the model with the area under the curve (AUC) of 0.943 (95% CI, 0.919–0.967) in training cohort and 0.916 (95% CI, 0.886–0.947) in the validation cohort. In the identification of BC and BBD, AUCs were 0.881 (95% CI, 0.848–0.914) and 0.849 (95% CI, 0.803–0.894) in training and validation cohort, respectively. In summary, our study indicates that the immunodiagnostic model can distinguish BC from NHC and BC from BBD and this model may have a potential application in immunodiagnosis of breast cancer.
Incidence, Epidemiology and Etiology of Injuries, in a Spanish Amateur Football Club

Background: Playing football, both at the amateur and professional level, associates an increased risk of injury. A documented report on injury location, type and incidence, in correlation with sports intensity, professionalism level and age, would be of support for implementing preventing measures and appropriate training programs, to reduce the incidence of football related injury. Objectives: This study aimed to assess the incidence, type and location of injuries during one season, in an amateur football club and design strategies and preventive measures. Patients and Methods: A population of 308 players were studied, aged between 5 and 29 years old (20 subjects over-19, 38 under-19, 38 under-16, 57 under-14, 57 under-12, 44 under-10 and 54 under-8 years old, respectively) distributed over 20 teams. In total, 339 cases of injury occurred. Results: The population injured the most was the under-19 group and the most prevalent type of injuries was muscular (40.7%) and ligament (16.5%). The most common location was the lower limbs (78.6%) and, specifically, the thigh (39.8%). Physical load periods (September and February) were highlighted as the months of highest incidence and the average number of visits per injury was 1.34. A statistically significant relationship between hours of training and injuries was noted. Conclusions: In the literature, there are similar publications, who studied these variables, separately. This work provides us with a certain amount of descriptive results, which may serve as a model for future research projects, performing interventions by coaches and medical services of football clubs, to reduce the injuries incidence, especially in the months of greatest physical load and, therefore, improve the performance. Football is a safe sport to practice, at any age, because injuries, regularly, are not serious and it is highly recommended, given the amount of health benefits obtained.