Miracle-dz/UniFAR-FTUs huggingface dataset:
Comparison study on three ice storage equipments using micro-tube heat exchanger for cold chain logistics

ABSTRACT Freezing efficiency was the main factor affecting the efficiency of cold chain logistics and transportation. To further the ice storage performance, three mathematical models of the ice storage equipments were established to explore the influence of the number and the diameter of the tubes on the freezing time, heat flux, and natural convection by analyzing the distribution of the ice fraction and velocity. The results showed that the total freezing time of Type II and Type III, which were arranged the micro-tube, were 76.42 min and 137.50 min, which was more than 90% less than that of type I. Due to a ring cavity of water appearing near the shell of the ice storage tank increased the water natural convection, the freezing time required to increase the ice fraction by 0.05 gradually increased especially with the ice fraction greater than 0.95. To better evaluate the ice storage performance, the freezing efficiency was introduced. The freezing efficiency of Type II and Type III was lower than that of Type I by more than 2.24% and 2.14%, respectively, for the ice fraction range of 0.75 ~ 1. Given the freezing time and ice storage efficiency, it could be found that using type II and making the ice storage rate reach 0.95 could shorten the freezing time and improve the ice storage efficiency.
Maximum isotope accumulation in the retrosplenial cortex during amnesia attack and its temporal change suggest cortical spreading depression as a pathophysiology of patients with transient global amnesia

Transient global amnesia (TGA) is a clinical syndrome that is characterized by the sudden onset of anterograde amnesia and a less prominent impairment in retrograde memory lasting up to 24 h. Although several etiologies have been proposed, including migraine, epilepsy, ischemia, venous congestion, and glutamate toxicity, none sufficiently explain the disorder in its entirety. We retrospectively investigated images obtained using single‐photon emission computed tomography (SPECT), performed with 99mtechnetium hexamethylpropyleneamine oxime, from 11 patients with TGA divided into the following groups based on the timing of SPECT: during TGA (n = 2, Group 1), at the start of the attenuation of memory impairments (n = 2, Group 2), and after TGA (n = 7, Group 3). Regional isotope accumulation was examined using a three‐dimensional stereotactic surface projection (3D‐SSP) analysis. After calculating the mathematical product of the mean severity and extent ratio, unique comparable bar graphs were prepared with respect to Brodmann's areas (B). Increases in isotope accumulation were the largest in the retrosplenial cortex (B29, B30), posterior cingulate cortex (B23, B31), and precuneus (B7) in Groups 1 and 2, whereas decreases were noted in the same regions in Group 3. This is the first study to identify cerebral sites and describe changes consistent with the completion of amnesia as a symptom using an image analysis, such as a 3D‐SSP analysis. We consider cortical spreading depression (CSD) to be the etiology of TGA based on maximum isotope accumulation in the above sites and a literature review on CSD.
Clinical and Histopathological Aspects of MRONJ in Cancer Patients

Medication-related osteonecrosis of the jaw (MRONJ) is a major complication of bisphosphonate treatment in cancer patients, and its etiology is not completely clarified. The study’s goal is to find connections between the clinical and histopathological characteristics of osteonecrosis and bisphosphonates in a cohort of cancer patients who had osteonecrosis treated surgically. The retrospective study includes 51 patients of both sexes, aged 46 to 85 years, who underwent surgical treatment for MRONJ in two oral and maxillofacial surgery clinics (Craiova and Constanța). Demographic, clinical, and imaging data from the records of patients with osteonecrosis were analyzed. The surgical treatment removed the necrotic bone, and the harvested fragments were analyzed from a histopathological perspective. The histopathological examination data were evaluated and statistically processed to look for viable bone, granulation tissue, bacterial colonies, and inflammatory infiltrate. In the study groups, MRONJ was found particularly in the posterior regions of the mandible. Tooth extraction, but also periapical or periodontal infections, represented the trigger factors in most of the cases. The surgical therapy consisted of sequestrectomy or bone resection, and the histopathological examination of the fragments revealed osteonecrosis-specific features, such as the lack of bone cells, the development of an inflammatory infiltrate, and the existence of bacterial colonies. MRONJ in cancer patients receiving zoledronic acid is a severe complication that significantly lowers quality of life. Since these patients are not usually monitored by the dentist, they are identified in advanced stages of MRONJ. For these patients, thorough dental monitoring could reduce the incidence of osteonecrosis and its related complications.
Rethinking Multi-Object Tracking Based on Re-Identification and Appearance Model Management

Conventional multi-object tracking (MOT) methods often fail to track objects that repeatedly disappear and reappear in the scene due to occlusion or moving off the screen. Previous studies have used motion and appearance information to address these issues but have limitations in dealing with complex scenarios. To overcome these limitations, we propose a post-hoc framework for MOT, a so-called rethinking MOT. The proposed framework efficiently combines MOT and re-identification methods to handle tracking failures in conventional MOT methods. To this end, we proposed a track reliability checking method to determine unreliable tracks and performed re-identification to correct incorrect tracking results. For re-identification, we proposed appearance aspect-ratio matching that is practical and effective. In addition, we designed an online appearance model management for accurate and efficient re-identification. The proposed framework does not require any offline training stages, such as feature or metric learning, but it is very practical for comparing appearances in real time. In addition, it is a flexible and pluggable framework that can adopt any baseline methods for MOT and Re-id. To validate the proposed methods, we collected 12 new challenging indoor datasets. Unlike the existing benchmark MOT datasets, we consider complex indoor sequences where targets reappear many times in the scene. The experimental results reveal that the proposed methods are promising for MOT under various challenging sequences and outperform state-of-the-art methods. Compared to baseline of the proposed rethinking MOT, the $IDF_{1}$ score was increased by 36.9% in own dataset and 50.4% in the benchmark dataset.
Application of Sucrose Acetate Isobutyrate in Development of Co-Amorphous Formulations of Tacrolimus for Bioavailability Enhancement

The focus of the present work was to develop co-amorphous dispersion (CAD) formulations of tacrolimus (TAC) using sucrose acetate isobutyrate as a carrier, evaluate by in vitro and in vivo methods and compare its performance with hydroxypropyl methylcellulose (HPMC) based amorphous solid dispersion (ASD) formulation. CAD and ASD formulations were prepared by solvent evaporation method followed by characterization by Fourier transformed infrared spectroscopy, X-ray powder diffraction (XRPD), differential scanning calorimetry (DSC), dissolution, stability, and pharmacokinetics. XRPD and DSC indicated amorphous phase transformation of the drug in the CAD and ASD formulations, and dissolved more than 85% of the drug in 90 min. No drug crystallization was observed in the thermogram and diffractogram of the formulations after storage at 25 °C/60% RH and 40 °C/75% RH. No significant change in the dissolution profile was observed after and before storage. SAIB-based CAD and HPMC-based ASD formulations were bioequivalent as they met 90% confidence of 90–11.1% for Cmax and AUC. The CAD and ASD formulations exhibited Cmax and AUC 1.7–1.8 and 1.5–1.8 folds of tablet formulations containing the drug’s crystalline phase. In conclusion, the stability, dissolution, and pharmacokinetic performance of SAIB-based CAD and HPMC-based ASD formulations were similar, and thus clinical performance would be similar.
PREVALENCE AND RISK FACTORS OF EIMERIA SPP. AND GIARDIA SPP. IN RABBITS OF LOCAL ALGERIAN POPULATION

The objective of this study was to determine the prevalence and to identify the risk factors of Eimeria spp. and Giardia spp. infection in rabbits from the local population of four localities in northern Algeria. Dung samples were collected from 16 farms, totalling 111 rabbits, and were analysed by the flotation method. Additional, data regarding the farms and management practices were obtained by means of a questionnaire used in the surveys and interviews. The results revealed that the prevalence of Eimeriaspp. contamination was 68.75% (11/16) for farms and 58.56% (65/111) for rabbits, respectively. The prevalence of Giardia spp. was respectively 56.25% (9/16) for farms and 11.7% (13/111) for rabbits. The analyses showed that the prevalence of Eimeria spp. was significantly higher in the farms that did not comply with hygiene and non-conventional feeding and watering. However, the prevalence of Giardia spp. was significant in rabbits kept in poor conditions of rearing. In conclusion, this study showed that the prevalence of these two parasites in rabbits from the local population is relevant and may have important implications for the rabbit industry and public health, especially in rural areas.
Tips and tricks for laparoscopic cholecystectomy in the patient with ventriculoperitoneal shunt; a case report

Laparoscopic surgery in patients with ventriculo-peritoneal shunt is challenging in terms of technical approach. The severity of possible complications and the lack of studies on this association increase the surgeon's discomfort with such surgery. The main complications that may occur are increased intracranial pressure, secondary pneumo-peritoneum pneumocephalus, encephalitis and the risk of catheter injury during laparoscopic procedures. We present the case of a 56-year-old patient operated in 2004 for a basilar artery top aneurysm with subarachnoid hemorrhage and secondary hydrocephalus, for which a ventriculo-peritoneal shunt was fitted. This patient presented in our clinic with diffuse abdominal pain, more accentuated in the right hypochondrium, nausea, postprandial biliary vomiting, inappetence, asthenia, fatigability, symptoms with onset about 6 months, but accentuated in the last 48 hours. The patient underwent surgery and the evolution was favorable, being discharged without postoperative complications.
Circulating and Endometrial Tissue microRNA Markers Associated with Endometrial Cancer Diagnosis, Prognosis, and Response to Treatment

Simple Summary Endometrial cancer (EC) is one of the most common gynecological malignancies. Therefore, it is of great clinical importance to identify potential candidates for diagnostic and prognostic biomarkers in order to identify high-risk patients and obtain a more accurate prognosis in a timely manner. MicroRNAs (miRs) are small single-stranded RNAs that regulate gene expression and play a role in all steps of cancer development. The miRs expressed in endometrial tumor tissue are probably involved in cell proliferation and differentiation, apoptosis, and carcinogenesis. We reviewed the literature to identify potential miRs that may function as diagnostic, prognostic, or response to treatment markers in EC. Abstract In developed countries, endometrial cancer (EC) is one of the most common neoplasms of the female reproductive system. MicroRNAs (miRs) are a class of single-stranded noncoding RNA molecules with lengths of 19–25 nucleotides that bind to target messenger RNA (mRNA) to regulate post-transcriptional gene expression. Although there is a large amount of research focused on identifying miRs with a diagnostic, prognostic, or response to treatment capacity in EC, these studies differ in terms of experimental methodology, types of samples used, selection criteria, and results obtained. Hence, there is a large amount of heterogeneous information that makes it difficult to identify potential miR biomarkers. We aimed to summarize the current knowledge on miRs that have been shown to be the most suitable potential markers for EC. We searched PubMed and Google Scholar without date restrictions or filters. We described 138 miRs with potential diagnostic, prognostic, or treatment response potential in EC. Seven diagnostic panels showed higher sensitivity and specificity for the diagnosis of EC than individual miRs. We further identified miRs up- or downregulated depending on the FIGO stage, precursor lesions, and staging after surgery, which provides insight into which miRs are expressed chronologically depending on the disease stage and/or that are modulated depending on the tumor grade based on histopathological evaluation.
Experimental investigation of unsteadiness of swept-ramp shock/boundary layer interactions at mach 2

This study examines the flow structure of a 3D shock wave/boundary layer interaction induced by a swept compression ramp in a Mach 2 flow. The swept ramp has a streamwise compression corner angle of 22.5 and a sweep angle of 30. A fluorescent-oil-flow technique is used to capture movies of the mean surface streaklines and stereo particle image velocimetry (PIV) is used to measure the three-component velocity field in a streamwisetransverse plane through the conical region of the interaction. PIV measurements close to the wind tunnel wall are enabled by using a windowed-ramp model that allows the laser sheet to propagate parallel to the wall and thus avoid laser glare. The surface flow visualisation movies very effectively reveal the mean separation line, reattachment line, transition to conical scaling, as well as the cross-flow and reverse-flow motions in the separated flow region. The mean velocity fields (u, v and w components) are consistent with the surface flow visualisation, and reveal reduced u in the separated flow region (between the mean separation line and reattachment), and large w in the direction of the cross-flow. The u-fields are in many ways similar to those observed in 2D compression ramp interactions. True reverse flow (negative u) is observed only in a small region close to the ramp corner over a transverse region of about 0.1 boundary layer thicknesses in height. The instantaneous velocity fields show a wide variation in separated flow size and an analysis was performed where the images were placed into bins of large or small separated flows and then ensemble averaged. These ensemble averaged fields reveal differences in the flow structure that are similar to what has been seen previously in 2D compression ramp interactions.
Plasma turbulence simulations in a diverted tokamak with applied resonant magnetic perturbations

The first results of three-dimensional, flux-driven, electrostatic, global, two-fluid turbulence simulations of a diverted tokamak configuration with applied resonant magnetic perturbations generated by a set of saddle coils are presented. The simulations of an L-mode plasma show that the heat flux pattern on the divertor targets is affected by the resonant magnetic perturbations, as a result of the interplay between turbulent cross field transport and parallel flows. The simulation results reveal the potential of resonant magnetic perturbations to reduce the heat flux to the wall. In fact, the peak of the toroidally- and time-averaged heat flux as well as its value integrated over the divertor decrease as the amplitude of the magnetic perturbation increases, while the plasma sources are held constant.
AIF1: Function and Connection with Inflammatory Diseases

Simple Summary Allograft inflammatory factor 1 (AIF1) is a calcium-binding protein that participates in intracellular processes such as phagocytosis, membrane ruffling and F-actin remodeling. Due to its multiple functions, AIF1 is linked with the activation of macrophages and several diseases such as kidney disease, rheumatoid arthritis, cancer, cardiovascular diseases, metabolic diseases, neurological disorders and transplants. In this review, we present a comprehensive review of the known structure, functions and role of AIF1 in inflammatory diseases. Abstract Macrophages are a type of immune cell distributed throughout all tissues of an organism. Allograft inflammatory factor 1 (AIF1) is a calcium-binding protein linked to the activation of macrophages. AIF1 is a key intracellular signaling molecule that participates in phagocytosis, membrane ruffling and F-actin polymerization. Moreover, it has several cell type-specific functions. AIF1 plays important roles in the development of several diseases: kidney disease, rheumatoid arthritis, cancer, cardiovascular diseases, metabolic diseases and neurological disorders, and in transplants. In this review, we present a comprehensive review of the known structure, functions and role of AIF1 in inflammatory diseases.
Contribution of Tropical Waves to the Formation of Supertyphoon Megi (2010)

AbstractThrough observational analysis and numerical simulations, this study examines the roles of the Madden–Julian oscillation (MJO) and tropical waves in the three-stage formation of Supertyphoon Megi (2010) including 1) convective bursts followed by vorticity aggregation, 2) vortex rearrangement during decaying convection, and 3) convective reinvigoration and vortex intensification. The MJO was responsible for preconditioning the large-scale circulation and low-level moisture favorable for convection during all stages, while the counterpropagating Kelvin and equatorial Rossby (ER) waves brought low-level convergence and cyclonic vorticity anomalies to enhance massive convection in the western tropical Pacific in stage 1. Convection strengthened the vorticity anomalies nearby, which subsequently developed into Megi’s embryo by the end of stage 1 through merging with the positive vorticity anomaly carried by a westward-propagating mixed Rossby–gravity and tropical depression (MRG–TD)-type wave. The ER- .
C *-Algebras of Infinite Graphs and Cuntz-Krieger Algebras

Abstract The Cuntz-Krieger algebra ${{\mathcal{O}}_{B}}$ is defined for an arbitrary, possibly infinite and infinite valued, matrix $B$ . A graph ${{C}^{*}}$ -algebra ${{G}^{*}}\left( E \right)$ is introduced for an arbitrary directed graph $E$ , and is shown to coincide with a previously defined graph algebra ${{C}^{*}}\left( E \right)$ if each source of $E$ emits only finitely many edges. Each graph algebra ${{G}^{*}}\left( E \right)$ is isomorphic to the Cuntz-Krieger algebra ${{\mathcal{O}}_{B}}$ where $B$ is the vertex matrix of $E$ .
Biosynthesis of Silver Nanoparticles Using the Biofilm Supernatant of Pseudomonas aeruginosa PA75 and Evaluation of Their Antibacterial, Antibiofilm, and Antitumor Activities

Purpose As an under-explored biomaterial, bacterial biofilms have a wide range of applications in the green synthesis of nanomaterials. The biofilm supernatant of Pseudomonas aeruginosa PA75 was used to synthesize novel silver nanoparticles (AgNPs). BF75-AgNPs were found to possess several biological properties. Methods In this study, we biosynthesized BF75-AgNPs using biofilm supernatant as the reducing agent, stabilizer, and dispersant and investigated their biopotential in terms of antibacterial, antibiofilm, and antitumor activities. Results The synthesized BF75-AgNPs demonstrated a typical face-centered cubic crystal structure; they were well dispersed; and they were spherical with a size of 13.899 ± 4.036 nm. The average zeta potential of the BF75-AgNPs was −31.0 ± 8.1 mV. The BF75-AgNPs exhibited strong antibacterial activities against the methicillin-resistant Staphylococcus aureus (MRSA), extended-spectrum beta-lactamase Escherichia coli (ESBL-EC), extensively drug-resistant Klebsiella pneumoniae (XDR-KP), and carbapenem-resistant Pseudomonas aeruginosa (CR-PA). Moreover, the BF75-AgNPs had a strong bactericidal effect on XDR-KP at 1/2 × MIC, and the expression level of reactive oxygen species (ROS) in bacteria was significantly increased. A synergistic effect was observed when the BF75-AgNPs and colistin were used for the co-treatment of two colistin-resistant XDR-KP strains, with fractional inhibitory concentration index (FICI) values of 0.281 and 0.187, respectively. Furthermore, the BF75-AgNPs demonstrated a strong biofilm inhibition activity and mature biofilm bactericidal activity against XDR-KP. The BF75-AgNPs also exhibited a strong antitumor activity against melanoma cells and low cytotoxicity against normal epidermal cells. In addition, the BF75-AgNPs increased the proportion of apoptotic cells in two melanoma cell lines, and the proportion of late apoptotic cells increased with BF75-AgNP concentration. Conclusion This study suggests that BF75-AgNPs synthesized from biofilm supernatant have broad prospects for antibacterial, antibiofilm, and antitumor applications.
Untargeted UHPLC-TOF/MS Lipidomic Analysis for the Investigation of Egg Yolks after Xylanase Supplementation of the Diet of Laying Hens

Xylanase supplementation of diets is used to enhance nutrient digestibility in monogastrics which lack necessary enzymes for non-starch polysaccharide degradation. The effects of enzymatic treatment in the nutritional value of the feed are typically not comprehensively studied. Though the fundamental effects of xylanase on performance are well studied, limited data is available on the complex interactions between xylanase supplementation and hen physiology; therefore, the aim of this study was to develop a new, simple UPLC-TOF/MS lipidomics method for the analysis of hen egg yolks after supplementation with different amounts of xylanase. Sample preparation for the extraction of lipids was optimized and different sample preparation modes and solvent mixtures were tested. Optimal results for the extraction of total lipids were obtained by using the solvent mixture MTBE: MeOH (5:1, v/v). Multivariate statistical analysis of the signals of hundreds of lipids in positive and negative ionisation modes highlighted differences in several egg yolk lipid species-classes. Four lipid species-classes, phosphatidylcholines (PC and PC O), phosphatidylethanolamines (PE and PE O), phosphatidylinositols (PI), and fatty acids (FA), were among those contributing to the separation of the experimental groups (control-treated) in negative ionisation mode. In positive ionisation mode, principal beneficial lipid compounds such as phosphatidylcholines (PC and PC O), phosphatidylethanolamines (PE and PE O), triacylglycerols (TG), diacylglycerols (DG), and ceramides (Cer) were found to be increased in treated groups. Overall, supplementation of laying hens’ diets with xylanase significantly changed the lipid profile of egg yolks compared to the control diet. The association between the lipid profiles of egg yolks and hens’ diets, as well as the underlying mechanisms, require further investigation. These findings are of practical significance for the food industry.