Miracle-dz/UniFAR-FTUs huggingface dataset:
Use of selective serotonin-reuptake inhibitors during early pregnancy and risk of congenital malformations: updated analysis

Background: Data on the safety of selective serotonin-reuptake inhibitors (SSRIs) in pregnancy are inconsistent. We examined associations between SSRI use during early pregnancy and risk of congenital malformations in infants. Methods: Set in Northern Denmark, our population-based prevalence study included 216,042 women who had a live birth after the 20th week of gestation. We compared the prevalence of malformation in infants born to women who redeemed at least one SSRI prescription during early pregnancy with the prevalence in infants born to women who redeemed no SSRI prescriptions during their pregnancies. Drug use data were extracted from prescription databases, while data on congenital malformations were obtained from the National Registry of Patients. Results: The 2,062 women with SSRI prescriptions during early pregnancy gave birth to 105 (5.1%) infants with malformations, while the 213,712 women with no SSRI prescriptions gave birth to 7,449 (3.5%) infants with malformations. SSRI use was associated with an increased risk of malformations overall (odds ratio [OR] = 1.3; 95% confidence interval (CI): 1.1–1.6) and cardiac malformations (OR = 1.7; 95% CI: 1.1–2.5). For specific SSRIs, we found an increased risk for septal defects associated with sertraline. Conclusions: We found little overall association between use of SSRIs during pregnancy and congenital malformations, but our findings suggest an association between maternal SSRI use in early pregnancy and cardiac malformations which could be causal. Clinical Epidemiology is an international, peer-reviewed, open access journal focusing on disease and drug epidemiology, identification of risk factors and screening procedures to develop optimal preventative initiatives and programs. Specific topics include: diagnosis, prognosis, treatment, screening, prevention, risk factor modification, systematic reviews, risk & safety of medical interventions, epidemiology & bio- statical methods, evaluation of guidelines, translational medicine, health policies & economic evaluations. The manuscript management system is completely online and includes a very quick and fair peer-review system, which is all easy to use.
Issues in Information Systems

The purpose of this study is to develop a research model using prior research and to investigate the influence of selfcontrol, time spent on Internet and relationship satisfaction on Internet addiction. The model includes the impact of self-control, the time spent on the Internet, and the relationship satisfaction on Internet addiction. We postulate that Internet addiction in its turn impacts academic success. The model was tested by using survey data and the results showed a relationship between self-control and time spent on Internet and Internet addiction. The study data did not support any significant connection between relationship satisfaction and the Internet addiction, as well as between Internet addiction and academic success.
Issues in Information Systems

The protection of personal information is an area of growing concern for individuals, organizations, and governments. Threats to information security in the healthcare sector carry additional risk since not only are patients’ identities and financial information at risk, but health data is at risk as well. The exposure of sensitive information can cause financial hardship, mental anguish, and in healthcare, lead to social stigma and impacts on medical decisions and treatment [3]. Health information is protected through federal regulation yet many healthcare facilities struggle to meet those requirements due to a variety of factors. This paper presents a theoretical framework of potential drivers of (non)compliance behaviors that may increase understanding of the barriers that small facilities face. The framework and propositions are presented.
Possible Non-melted Remnants of Subducted Lithosphere: Experimental and Geochemical Evidence from Corundum-Bearing Mafic Rocks in the Horoman Peridotite Complex, Japan

Morishita, T. & Arai, S. (2001). Petrogenesis of corundum-bearing mafic rock in the Horoman Peridotite Complex, Japan. Journal of Petrology 42, 1279---1299. Morishita, T. & Kodera, T. (1998). Finding of corundum-bearing gabbro boulder possibly derived from the Horoman Peridotite Complex, Hokkaido, northern Japan. Journal of Mineralogy, Petrology and Economic Geology 93, 52---63. Morishita, T. , Arai, S. & Gervilla, F. (2001). High-pressure aluminous mafic rocks from the Ronda peridotite massif, southern Spain: significance of sapphirineand corundum-bearing mineral assemblages. Lithos 57, 143---161. Morishita, T. , Arai, S. & Green, D. H. (2003a). Evolution of low-Al orthopyroxene in the Horoman peridotite, Japan: an unusual indicator of metasomatising fluids. Journal of Petrology 44,
PRELIMINARY PROBING INTO TOURISM URBANIZATION ——A CASE STUDY OF METROPOLITAN INTERLOCKING REGION IN YANGTZE RIVER DELTA

Urbanization takes its shape when motivated by urbanization development, concentration of urban tourist resources, gathering and pervasion of population and economy, combination of tourism supply and demands, tourists' selection of urban destination, policy orientation, tourism development and improvement of transportation facilities, etc. Taking the metropolitan interlocking region in Yangtze River Delta as a study case, this paper analyses problems existing in the process of tourism urbanization, such as ambiguous mind on development, destruction of landscape and ecological environment, imparity between tourism planning and city planning and development, confusion of population management, undefined land use functions and severe waste of land resources, etc. Countermeasures to its further development are thus brought out.
Issues in Information Systems

Distance education has taken on many forms and evolved tremendously with the advancement of new technologies, however impediments remain as we attempt to deliver instruction to student audiences across a variety of locations. This paper presents a case study which examines a particularly unique set of challenges: delivery of an information systems course to graduate students who live on disparate islands in the Caribbean. The authors examine a number of factors that impact student learning through both quantitative and qualitative means, concluding that the degradation of instructor presence, regardless of cause, is the primary reason for decreased student performance in the multi-site Information Systems classroom.
Kinematics and geometry of active detachment faulting beneath the Trans-Atlantic Geotraverse (TAG) hydrothermal fi eld on the

Newly acquired seismic refraction and microearthquake data from the Trans-Atlantic Geotraverse (TAG) segment of the Mid-Atlantic Ridge at 26°N reveal for the fi rst time the geometry and seismic character of an active oceanic detachment fault. Hypocenters from 19,232 microearthquakes observed during an eight month ocean bottom seismometer deployment form an ~15-km-long, dome-shaped fault surface that penetrates to depths >7 km below the seafl oor on a steeply dipping (~70°) interface. A tomographic model of compressional-wave velocities demonstrates that lower crustal rocks are being exhumed in the detachment footwall, which appears to roll over to a shallow dip of 20° ± 5° and become aseismic at a depth of ~3 km. Outboard of the detachment the exhumed lithosphere is deformed by ridge-parallel, antithetical normal faulting. Our results suggest that hydrothermal fl uids at the TAG fi eld exploit the detachment fault to extract heat from a region near the crust-mantle interface over long periods of time.
Decavanadate-Bearing Guanidine Derivatives Developed as Antimicrobial and Antitumor Species

To obtain biologically active species, a series of decavanadates (Hpbg)4[H2V10O28]·6H2O (1) (Htbg)4[H2V10O28]·6H2O; (2) (Hgnd)2(Hgnu)4[V10O28]; (3) (Hgnu)6[V10O28]·2H2O; and (4) (pbg = 1-phenyl biguanide, tbg = 1-(o-tolyl)biguanide, gnd = guanidine, and gnu = guanylurea) were synthesized and characterized by several spectroscopic techniques (IR, UV-Vis, and EPR) as well as by single crystal X-ray diffraction. Compound (1) crystallizes in space group P-1 while (3) and (4) adopt the same centrosymmetric space group P21/n. The unusual signal identified by EPR spectroscopy was assigned to a charge-transfer π(O)→d(V) process. Both stability in solution and reactivity towards reactive oxygen species (O2− and OH·) were screened through EPR signal modification. All compounds inhibited the development of Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Enterococcus faecalis bacterial strains in a planktonic state at a micromolar level, the most active being compound (3). However, the experiments conducted at a minimal inhibitory concentration (MIC) indicated that the compounds do not disrupt the biofilm produced by these bacterial strains. The cytotoxicity assayed against A375 human melanoma cells and BJ human fibroblasts by testing the viability, lactate dehydrogenase, and nitric oxide levels indicated compound (1) as the most active in tumor cells.
Attributes of Entreprenuers at an Arts Festival

The purpose of this article is to determine the attributes of entrepreneurs at festivals, in this case an arts festival. The reason for choosing an arts festival is that the largest festivals (judged by number of visitors and income generated) hosted in South Africa annually are arts festivals. A literature review revealed that this type of study had not previously been conducted in South Africa. In order to generate proper data, a survey was conducted of all small businesses that were trading at one of South Africa’s largest arts festivals, namely the Aardklop National Arts Festival, held annually in the city of Potchefstroom. 222 useable questionnaires were captured and the data analysis included a factor analysis and descriptive results. The main results reveal that the most important attributes are a need for achievement, being successful, having the necessary organising skills, selfedification, being explorative, and commitment. Key words: entrepreneurs, arts festivals, event tourism, South Africa, attributes, Aardklop National Arts Festival
Growth and health state of silver fir ( Abies alba Mill.) in the ridge area of the Jizerské hory Mts.

The silver fir was planted under mountain conditions in order to reveal its response to the addition of finely ground rocks (limestone and amphibolite) mixed with soil into the planting holes. The results document that the increments of the plantations fertilised with amphibolite were higher by 25% on average than those of the control plantations while the increments of the plantations treated with dolomitic limestone were lower by 13%. Generally, as concerns both the plantations with the application of ground rocks and the control ones, the development of the fir plantations in 1994-2007 is considered successful. As the damage by climatic stresses has gradually diminished, the number of dead trees has been decreasing and the height increments have been increasing in the last years, therefore a positive development is to be expected also in future.
Cultural Value and Locality in the Merapi Daily Short Story Collection “Lintang Johar Cikal Bakal Mataram Islam”

Cultural Values And Locality In The Collection Of Daily Merapi Short Stories “Lintang Johar Cikal Bakal Mataram Islam” By Iis Suwartini. The presence of literary works is closely related to the culture that exists in society. Literary works exist as a means to invite people to live in tune with the existing culture. In line with this, this study aims to determine the values of Javanese culture and locality contained in the Kumoulan Kompas Daily Short Story "Lintang Johar Cikal Bakal Mataram Islam" by iis Suwartini. This research is descriptive qualitative research. The main data source which is the object of study in this research is the Kompas Daily Short Story Collection published in 2021 by Iis Suwartini. Retrieval of research data is done through heuristic reading techniques. The interactive data analysis technique from Miles & Huberman is a data analysis technique which includes techniques of: (1) collecting data, (2) reducing data, (3) presenting data, and (4) drawing conclusions. This research produces written data. The results of the study show that the cultural values contained in a collection of short stories are 1) the nature of human life, 2) the nature of human work, 3) the nature of human position in space and time, 4) the nature of the relationship between humans and nature, and 5) the nature of the relationship between humans. The locality that appears is the locality of Java, which has been successfully identified through the characters, plot, setting, style of language and story title. Overall, this research is expected to be a basis for bringing up relevant research related to cultural values and locality in literary works.
SUMMARY OF SWORDFISH (Xiphias gladius) RECAPTURES CARRIED OUT BY THE SPANISH SURFACE LONGLINE FLEET IN THE ATLANTIC OCEAN: 1984-2002.

A total of 66 swordfish (Xiphias gladius) specimens were recovered during the 1984-2002 period from the fishing areas of the Atlantic Ocean. These recaptures were reported to the Instituto Espanol de Oceanografia. Almost all of the recaptures were submitted by the commercial Spanish surface longline fleet, with the exception of one tag, which was reported by the U.S. fleet. The origin of the recaptures may be broken down as follows: 11 came from swordfishes tagged by the Spanish surface longline fleet (a recapture rate of 0.33%), 8 from swordfishes tagged by the scientific staff of the IEO during tagging surveys (a recapture rate of 6.11%) and 47 recaptures pertained to swordfishes tagged by other countries. A total of 7 tags came from fishes tagged and recaptured in the South Atlantic (South of 10o South). In spite of the small increase seen in the number of fishes tagged and recaptured in the North East Atlantic, complex exchanges are already being inferred between areas at the level of the North Atlantic. Moreover, the data available do not suggest any trans-equatorial movements. RESUME
Associations Between Negative Context of Reception and Depressive Symptoms Among Immigrant Latino Men: The Moderating Effect of Machismo and Hispanicism

This study examines the cumulative effects of negative context of reception (NCR), traditional Latino gender norms, and acculturation on depressive symptoms among adult Latino immigrant men, and if levels of acculturation and traditional Latino gender norms moderated associations between NCR and depressive symptoms in the study sample. Hierarchical Multiple Regression (HMR) and moderation analyses were conducted on a cross-sectional sample of 280 Latino men. Predictor variables were entered into the HMR model: (1) demographic variables, (2) perceived stress, (3) acculturation and gender norms, and (4) NCR. Subsequently, moderation analysis was conducted using PROCESS v3.2 model 1. 19% of the variance of depressive symptoms was explained by all predictor variables entered in the HMR model. Moderation analyses revealed significant interaction effects with machismo (exacerbating) and Hispanicism (attenuating) the association between NCR and depressive symptoms. Study findings have implications for culturally appropriate interventions that target gender norms among Latino immigrant men.
Systematic Reviews and Meta-and Pooled Analyses Body Mass Index , Cigarette Smoking , and Alcohol Consumption and Cancers of the Oral Cavity , Pharynx , and Larynx : Modeling Odds Ratios in Pooled Case-Control Data

Jay H. Lubin*, Mia M. Gaudet, Andrew F. Olshan, Karl Kelsey, Paolo Boffetta, Paul Brennan, Xavier Castellsague, Chu Chen, Maria Paula Curado, Luigino Dal Maso, Alexander W. Daudt, Eleonora Fabianova, Leticia Fernandez, Victor Wünsch-Filho, Silvia Franceschi, Rolando Herrero, Sergio Koifman, Carlo La Vecchia, Philip Lazarus, Fabio Levi, Jolanta Lissowska, Ioan Nicolae Mates, Elena Matos, Michael McClean, Ana Menezes, Hal Morgenstern, Joshua Muscat, Jose Eluf Neto, Mark P. Purdue, Peter Rudnai, Stephen M. Schwartz, Oxana Shangina, Erich M. Sturgis, Neonilia Szeszenia-Dabrowska, Renato Talamini, Qingyi Wei, Deborah Winn, Zuo-Feng Zhang, Mia Hashibe, and Richard B. Hayes
Cardiopulmonary resuscitation: difficulty in maintaining sufficient compression depth at the appropriate rate

Over the last 50 years, the recommended chest compression for cardiopulmonary resuscitation (CPR) has become faster and deeper, but maintaining deep compressions may be difficult at higher rates. Our study aimed to determine whether adequate compression (chest compression at an appropriate depth and rate) is being performed in emergency departments (ED). We also investigated the effect of adequate compression performance on the return of spontaneous circulation (ROSC). This prospective observational study was conducted at the EDs of two urban academic medical centers. We included adult patients (age ≥18 years) with cardiac arrest who underwent CPR in the ED between May and November 2020. We excluded patients with cardiac arrest related to trauma, repeated arrest except the first, and those for whom a monitor-defibrillator (ZOLL X-series) was not used. The following data were obtained from the monitor-defibrillator devices: compression depth, rate, chest compression fraction, CPR time, and percentage of compressions at the recommended rate and, at the recommended depth, at over and below rates, and depth, and at the appropriate depth and rate. Our study included 50 patients, from whom 441 chest compression sequences were obtained and analyzed. The mean compression depth, rate, and fraction were 6.48 ± 0.87 cm, 117 ± 5/min, 92.1 ± 3.70%, respectively. As the compression rate increased, the depth decreased, and most compressions were over-depth. Adequate compression (appropriate depth at recommended rate) was observed in 97 of the 441 compression sequences (21.9%). Below-depth and below-rate percentages were higher in the deceased group than that in the ROSC group (9.7 ± 15.2% vs. 3.3 ± 3.5%, p = 0.27; 2.7 ± 2.6% vs. 1.2± 0.9%, p = 0.06). The global ratio of chest compression showed low compliance with the recommended rate and depth, even when performed by skilled ED staff.
Stratigraphy, Evolution, and Controls of A Holocene Transgressive–Regressive Barrier Island Under Changing Sea Level: Danish North Sea Coast

Abstract This study provides a detailed reconstruction of the formation of a wave-dominated barrier island and assesses the sedimentological and morphological effects of sea-level changes on barrier evolution. Sedimentological and stratigraphic characteristics of the Holocene deposits are resolved by percussion cores and an extensive ground-penetrating-radar survey. A high-resolution chronology of the cored barrier island deposits is constructed by optically stimulated luminescence dating. This approach facilitates a high spatio-temporal resolution of the island’s morphological and depositional evolution. The results show that the barrier island experienced multiple phases of transgressions and regressions during the mid- and late Holocene and that these changes were driven primarily by changes in rates of sea-level rise, sediment supply and the impact of storms. Due to the postglacial sea-level rise, the seaward part of the study area was transgressed by the retreating mainland shoreline, forming a back-barrier basin. At the time of the initial transgression, sea level was rising by more than 4.0 mm yr−1. As sea-level rise decreased to less than 2 mm yr−1 the back-barrier basin rapidly started to fill with sediments before being transgressed by the still retreating open-ocean shoreline. These events were associated with periods of very rapid landward displacement of up to 10 m yr−1 of the mainland shoreline. After stabilization of the barrier island in its most eastward (i.e., landward) location, the open-ocean shoreline prograded about 3 km seaward at a rate of > 3 m yr−1 through the deposition of a 7-m-thick sandy beach and shoreface succession. The progradation occurred despite a sea-level rise of about 1.8 mm yr−1. After the regressive period the barrier island once again became transgressive before shifting back to its current regressive stage. The study shows how comparable rates of sea-level rise can result in very different morphological responses for a single barrier island since sediment supply apparently has varied significantly through time. It also appears that a transgressive situation is reached for this particular barrier island for a sea-level rise higher than about 2 mm yr−1. This gives reason for concern since a number of sea-level change scenarios indicate that such a rate will be reached within a few decades.
Biotechnology and Bioengineering

Funding information German Federal Ministry of Education and Research (BMBF), Grant/Award Number: FKZ: 031A227F; Arbeitsgemeinschaft industrieller Forschungsvereinigungen (AiF), Grant/Award Number: IGF‐Vorhaben 18180 N; Center for Chemical Polymer Technology (CPT), Grant/ Award Number: EFRE 30 00 883 02 Abstract Accumulation of plastics in the environment became a geological indicator of the Anthropocene era. An effective reduction of long‐lasting plastics requires a treatment with micro‐organisms that release polymer‐degrading enzymes. Polymer binding peptides function as adhesion promoters and enable a targeted binding of whole cells to polymer surfaces. An esterase A‐based Escherichia coli cell surface display screening system was developed, that enabled directed evolution of polymer binding peptides for improved binding strength to polymers. The E. coli cell surface screening system facilitates an enrichment of improved binding peptides from a culture broth through immobilization of whole cells on polymer beads. The polypropylene (PP)‐binding peptide liquid chromatography peak I (LCI) was simultaneously saturated at five positions (Y29, D31, G35, E42, and D45; 3.2 million variants) and screened for improved PP‐binding in the presence of the anionic surfactant sodium dodecylbenzenesulfonate (LAS; 0.25mM). The cell surface system enabled efficient screening of the generated LCI diversity (in total ~10 million clones were screened). Characterization of identified LCI binders revealed an up to 12‐fold improvement (eGFP‐LCI‐CSD‐3: E42V/D45H) in PP‐binding strength in the presence of the surfactant LAS (0.125mM). The latter represents a first whole cell display screening system to improve adhesion peptides which can be used to direct and to immobilize organisms specifically to polymer surfaces (e.g., PP) and novel applications (e.g., in targeted plastic degradation).
International Journal of Soft Computing and Engineering

18 Retrieval Number: E3083117517/2017©BEIESP Published By: Blue Eyes Intelligence Engineering & Sciences Publication  Abstract: Volatility Forecasting is an interesting and challenging problem in current financial instruments. There are many financial risks and rewards directly associated with volatility. Hence forecasting volatility becomes the most discussed topic in finance. In this research we apply various univariate conditional heteroskedasticity models for forecasting volatility. The various extensions of the standard Generalized ARCH models such as SGarch, CSGarch, Egarch, IGarch and GJRGarch are used for forecasting. Volatility values are forecasted for 10 days in advance and values are compared with the actual values. Mean square error is computed between Garch forecast and actual values for the 10 days. The model with lowest MSE values over 10 forecasted periods is selected as the best performing model. The forecasted results for 10 days show that GJRGarch ranks top in the accuracy of forecasting and IGarch at the bottom. GJRGarch outperforms all other univariate ARCH models.