Miracle-dz/UniFAR-FTUs huggingface dataset:
High-Resolution Crustal S-wave Velocity Model and Moho Geometry Beneath the Southeastern Alps: New Insights From the SWATH-D Experiment

We compiled a dataset of continuous recordings from the temporary and permanent seismic networks to compute the high-resolution 3D S-wave velocity model of the Southeastern Alps, the western part of the external Dinarides, and the Friuli and Venetian plains through ambient noise tomography. Part of the dataset is recorded by the SWATH-D temporary network and permanent networks in Italy, Austria, Slovenia and Croatia between October 2017 and July 2018. We computed 4050 vertical component cross-correlations to obtain the empirical Rayleigh wave Green’s functions. The dataset is complemented by adopting 1804 high-quality correlograms from other studies. The fast-marching method for 2D surface wave tomography is applied to the phase velocity dispersion curves in the 2–30 s period band. The resulting local dispersion curves are inverted for 1D S-wave velocity profiles using the non-perturbational and perturbational inversion methods. We assembled the 1D S-wave velocity profiles into a pseudo-3D S-wave velocity model from the surface down to 60 km depth. A range of iso-velocities, representing the crystalline basement depth and the crustal thickness, are determined. We found the average depth over the 2.8–3.0 and 4.1–4.3 km/s iso-velocity ranges to be reasonable representations of the crystalline basement and Moho depths, respectively. The basement depth map shows that the shallower crystalline basement beneath the Schio-Vicenza fault highlights the boundary between the deeper Venetian and Friuli plains to the east and the Po-plain to the west. The estimated Moho depth map displays a thickened crust along the boundary between the Friuli plain and the external Dinarides. It also reveals a N-S narrow corridor of crustal thinning to the east of the junction of Giudicarie and Periadriatic lines, which was not reported by other seismic imaging studies. This corridor of shallower Moho is located beneath the surface outcrop of the Permian magmatic rocks and seems to be connected to the continuation of the Permian magmatism to the deep-seated crust. We compared the shallow crustal velocities and the hypocentral location of the earthquakes in the Southern foothills of the Alps. It revealed that the seismicity mainly occurs in the S-wave velocity range between ∼3.1 and ∼3.6 km/s.
Personality Functioning and Mentalizing in Patients With Subthreshold or Diagnosed Borderline Personality Disorder: Implications for ICD-11

The 11th revision of the International Classification of Diseases for Mortality and Morbidity Statistics (ICD-11) defines personality disorder according to personality functioning, which relates to self- and interpersonal functioning. The aim of the present study was to assess the relationship between mentalizing and personality functioning in patients with subthreshold or diagnosed borderline personality disorder. A total of 116 eligible participants were included. Mentalizing was assessed using the Mentalization Questionnaire (MZQ), personality functioning (self- and interpersonal functioning) was assessed using the Level of Personality Functioning Scale-Brief Form 2.0 (LPFS-BF), and borderline severity was assessed using the Zanarini Rating Scale (ZAN-BPD). Mediation analysis was employed to test if mentalizing accounted for the relationship between borderline severity and self- and interpersonal functioning. We found a significant relationship between borderline severity and both subscales of the LPFS-BF. Mentalizing fully and significantly mediated the relationship between borderline severity and interpersonal functioning. However, mentalizing only partly mediated the relationship between borderline severity and self-functioning. Controlling for the covariates gender and age did not impact the results. Mentalizing is likely to be involved in the ICD-11 model of personality functioning, especially interpersonal functioning. This could emphasize the relevance of therapy aimed at strengthening mentalizing abilities when treating personality pathology in general and people with borderline personality disorder in particular. However, self-functioning may be more nuanced, as aspects other than mentalizing also influence self-functioning. The study is explorative in nature and has methodological limitations that require caution in the interpretation and generalizability.
Lytic Bacteriophage EFA1 Modulates HCT116 Colon Cancer Cell Growth and Upregulates ROS Production in an Enterococcus faecalis Co-culture System

Enterococcus faecalis is an opportunistic pathogen in the gut microbiota that’s associated with a range of difficult to treat nosocomial infections. It is also known to be associated with some colorectal cancers. Its resistance to a range of antibiotics and capacity to form biofilms increase its virulence. Unlike antibiotics, bacteriophages are capable of disrupting biofilms which are key in the pathogenesis of diseases such as UTIs and some cancers. In this study, bacteriophage EFA1, lytic against E. faecalis, was isolated and its genome fully sequenced and analyzed in silico. Electron microscopy images revealed EFA1 to be a Siphovirus. The bacteriophage was functionally assessed and shown to disrupt E. faecalis biofilms as well as modulate the growth stimulatory effects of E. faecalis in a HCT116 colon cancer cell co-culture system, possibly via the effects of ROS. The potential exists for further testing of bacteriophage EFA1 in these systems as well as in vivo models.
Correlates of Psychological Distress Among Pakistani Adults During the COVID-19 Outbreak: Parallel and Serial Mediation Analyses

Objective: The global outbreak of COVID-19 has greatly affected individual's lives around the world and resulted in various negative psychological consequences. During the pandemic, reflection on and attention to COVID-19 may help in dealing with its symptomology but frequent and persistent thoughts about the situation can be unhealthy. The present study examined the direct and indirect associations between obsession concerning COVID-19, psychological distress, life satisfaction, and meaning in life. Design: This mediation study presents a primary analysis of normative data collected after the initial outbreak of COVID-19 in Pakistan. Parametric bootstrapping was used to test the mediation models of subjective well-being, the extent of the effect, and meaning in life as parallel and serial mediators concerning the associations between COVID-19 obsession and psychological distress measures. Setting: A sample of 1,002 adults (45% men and 55% women) were recruited utilizing an online survey between April to May 2020. They were aged between 19 and 45 years (M = 24.30, SD = 7.29) and normalized on population characteristics. Results: Two out of three mediators in parallel mediation fully mediated the relationship between obsession and psychological distress (total effect = 0.443, SE = 0.050, p < 0.0001) illustrating that high-level obsessions were associated with low levels of satisfaction with life and presence of meaning in life and search for meaning in life. Psychological distress is likely to decrease in the presence of a high level of satisfaction with life and meaning. Moreover, satisfaction with life and search for meaning in life significantly mediated the association between COVID-19 obsession (z=-3.507, p < 0.0001 and z = −2.632, p < 0.001 respectively). Conclusion: The present study showed that life satisfaction and search for meaning in life may play a significant role in decreasing psychological distress during the COVID-19 pandemic.
Molecular Cytogenetic and Agronomic Characterization of the Similarities and Differences Between Wheat–Leymus mollis Trin. and Wheat–Psathyrostachys huashanica Keng 3Ns (3D) Substitution Lines

Psathyrostachys huashanica Keng (2n = 2x = 14, NsNs) and Leymus mollis Trin. (2n = 4x = 28, NsNsXmXm) are valuable resources for wheat breeding improvement as they share the Ns genome, which contains diverse resistance genes. To explore the behaviors and traits of Ns chromosomes from the two species in wheat background, a series of wheat–P. huashanica and wheat–L. mollis substitution lines were developed. In the present study, line DH109 (F7 progeny of wheat–P. huashanica heptaploid line H8911 × durum wheat Trs-372) and line DM131 (F8 progeny of wheat–L. mollis octoploid line M842 × durum wheat Trs-372) were selected. Cytological observation combined with genomic in situ hybridization experiments showed that DH109 and DM131 each had 20 pairs of wheat chromosomes plus a pair of alien chromosomes (Ns chromosome), and the pair of alien chromosomes showed stable inheritance. Multiple molecular markers and wheat 55K SNP array demonstrated that a pair of wheat 3D chromosome in DH109 and in DM131 was substituted by a pair of P. huashanica 3Ns chromosome and a pair of L. mollis 3Ns chromosome, respectively. Fluorescence in situ hybridization (FISH) analysis confirmed that wheat 3D chromosomes were absent from DH109 and DM131, and chromosomal FISH karyotypes of wheat 3D, P. huashanica 3Ns, and L. mollis 3Ns were different. Moreover, the two lines had many differences in agronomic traits. Comparing with their wheat parents, DH109 expressed superior resistance to powdery mildew and fusarium head blight, whereas DM131 had powdery mildew resistance, longer spike, and more tiller number. Therefore, Ns genome from P. huashanica and L. mollis might have some different effects. The two novel wheat–alien substitution lines provide new ideas and resources for disease resistance and high-yield breeding on further utilization of 3Ns chromosomes of P. huashanica or L. mollis.
Association of Metabolic Syndrome With Prevalence of Obstructive Sleep Apnea and Remission After Sleeve Gastrectomy

Obesity is an important risk factor for metabolic syndrome and obstructive sleep apnea (OSA). Bariatric surgery has been shown to effectively reduce weight and obesity-related comorbidities. However, the prevalence and severity of OSA in obese patients with different baseline metabolic states and the improvements of OSA after bariatric surgery remain unknown. The main aims of this study were to ascertain the prevalence of OSA in young Chinese obese patients with different metabolic states and to evaluate their respective OSA remission after laparoscopic sleeve gastrectomy. We first performed a cross-sectional study involving 123 metabolically healthy obese patients and 200 metabolically unhealthy obese patients (who had the same age and BMI ranges) to estimate the prevalence of OSA at baseline. Then we performed a retrospective study, which was registered at ClinicalTrials.gov (ref. NCT02653430) of 67 patients who underwent laparoscopic sleeve gastrectomy to evaluate the remission of OSA. Metabolically healthy and unhealthy obese patients had similar apnea-hypopnea index levels (16.6 ± 22.0 vs. 16.7 ± 18.7 events/h, P = 0.512) and prevalence of OSA (66.7% vs. 69.0%, P = 0.662). Male sex, age, waist circumference and lower liver-to-spleen ratio were independent risk factors for OSA. After laparoscopic sleeve gastrectomy, no difference was found in the decrease in body mass index (BMI) change (10.8 ± 4.8 vs. 10.8 ± 3.0 kg/m2, P = 0.996) or the decrease in the apnea-hypopnea index (18.9 ± 24.6 vs. 17.0 ± 24.0 events/h, P = 0.800). The remission of moderate-to-severe OSA was observed in the MHO (36.3%; 54.5–18.2%, P = 0.125) and MUO (32.2%; 66.1–33.9%, P = 0.001) patients. These results suggest that, in patients with obesity, metabolic syndrome does not add extra risk for the prevalence or severity of OSA. Both metabolically healthy and unhealthy obese patients could benefit equally from laparoscopic sleeve gastrectomy in terms of weight loss and obstructive sleep apnea remission.
Selenium Kinetics in Humans Change Following 2 Years of Supplementation With Selenomethionine

Background Selenium (Se) is a nutritionally essential trace element and health may be improved by increased Se intake. Previous kinetic studies have shown differences in metabolism of organic vs. inorganic forms of Se [e.g., higher absorption of selenomethionine (SeMet) than selenite (Sel), and more recycling of Se from SeMet than Sel]. However, the effects on Se metabolism after prolonged Se supplementation are not known. Objective To determine how the metabolism and transport of Se changes in the whole-body in response to Se-supplementation by measuring Se kinetics before and after 2 years of Se supplementation with SeMet. Methods We compared Se kinetics in humans [n = 31, aged 40 ± 3 y (mean ± SEM)] studied twice after oral tracer administration; initially (PK1), then after supplementation for 2 y with 200 µg/d of Se as selenomethionine (SeMet) (PK2). On each occasion, we administered two stable isotope tracers of Se orally: SeMet, the predominant food form, and selenite (Na2 76SeO3, or Sel), an inorganic form. Plasma and RBC were sampled for 4 mo; urine and feces were collected for the initial 12 d of each period. Samples were analyzed for tracers and total Se by isotope dilution GC-MS. Data were analyzed using a compartmental model, we published previously, to estimate fractional transfer between pools and pool masses in PK2. Results We report that fractional absorption of SeMet or Sel do not change with SeMet supplementation and the amount of Se absorbed increased. The amount of Se excreted in urine increases but does not account for all the Se absorbed. As a result, there is a net incorporation of SeMet into various body pools. Nine of the 11 plasma pools doubled in PK2; two did not change. Differences in metabolism were observed for SeMet and Sel; RBC uptake increased 247% for SeMet, urinary excretion increased from two plasma pools for Sel and from two different pools for SeMet, and recycling to liver/tissues increased from one plasma pool for Sel and from two others for SeMet. One plasma pool increased more in males than females in PK2. Conclusions Of 11 Se pools identified kinetically in human plasma, two did not increase in size after SeMet supplementation. These pools may be regulated and important during low Se intake.
DISPOSITION KINETICS OF CIPROFLOXACIN AFTER DIFFERENT ORAL DOSAGE LEVEL IN RABBITS

Ciprofloxacin a flouroquinolone antibacterial drug was orally administered to healthy white albino rabbits (n = 12) a single dose of 10, 20, and 30 mg/Kg body weight using a randomized crossover design. Plasma samples were collected at various times over 12 hours following drug administration. The drugs were detected by high performance liquid chromatography (HPLC), and plasma drug concentration versus time curve were subjected to non-compartment and two compartment pharmacokinetic analysis. Descriptive statistics were determined for each doses, and comparison were made among doses groups for selected pharmacokinetic parameters. Result indicated that increasing dose of ciprofloxacin resulted in increased plasma concentration. Maximum concentration (Cmax) was 0.43 ± 0.007, 0.84 ± 0.01, and 1.46± 0.0l3 µgm/ml for the doses of 10, 20, and 30mg/kg body weight. AUC(0-t), AUC(0-∞) and MRT were significantly greater at 30mg/kg and showed significant difference with doses(P<0.05), where as other parameters like absorption rate constant, distribution rate constant and elimination rate constant did not show significant difference.
Not All in the Same Boat. Socioeconomic Differences in Marital Stress and Satisfaction During the Covid-19 Pandemic

The Covid-19 pandemic is a global threat that affects a large part of the population, but the risks associated with it are higher for some people compared with others. Previous studies show that lower socioeconomic status (SES) is associated with more chronic stress and less marital satisfaction. Thus, the uncertainty caused by the pandemic might greatly affect those who were already vulnerable. This longitudinal study explores the extent to which stress originated outside (external) and inside (internal) the relationship is associated with marital satisfaction during the Covid-19 pandemic and whether the associations are different based on the socioeconomic status of the participants. The study was conducted at two points in time (first, immediately after the national lockdown was instituted; second, after the lockdown ended) with a sample of 144 married Romanian couples. We used the Actor-Partner Interdependence Model with Mediation and multi-group SEM analysis. Higher levels of external stress were associated with subsequent lower marital satisfaction for women with higher SES. For the couples with lower SES, men's level of internal stress during the first assessment mediated the relationship between their higher level of external stress at the first time point and their partner's lower marital satisfaction during the second assessment. Our results show that men and women respond differently during a crisis and that couples with lower SES are more prone to greater stress and lower levels of marital satisfaction. We finally suggest that the therapists, health professionals, policy makers, and researchers should take into account the existing vulnerabilities of a couple when offering psychological and health services during the Covid-19 pandemic.
Serum Uric Acid Level Is Positively Associated With Higher Bone Mineral Density at Multiple Skeletal Sites Among Healthy Qataris

Background Oxidative stress has been implicated as a fundamental mechanism in the decline of bone mass. Although serum uric acid (SUA) has potent antioxidant properties, the findings of many epidemiological and experimental studies couldn’t draw a clear conclusion on the relation between SUA and bone health. We aim to investigate the association between SUA and bone mineral density (BMD) at different skeletal sites among healthy Qataris. Methodology A cross-sectional analysis including total-body and site-specific bone mineral density scores and other serological markers of 2981 healthy Qatari adults (36.4 ± 11.1 years) from the Qatar biobank database was conducted. The study participants were divided into quartiles based on the level of SUA, and the BMD was measured using dual-energy X-ray absorptiometry (DXA). Multiple regression analyses were applied to investigate the association between SUA and BMD adjusting for multiple confounding factors. Results High levels of SUA were significantly associated with the increased bone mineral density of the total body and at site-specific skeletal locations after adjusting for age and gender (p-value < 0.001). Further adjustment for body mass index (BMI), smoking, vitamin D, alkaline phosphatase, and estimated glomerular filtration rate (eGFR) levels attenuated the association but the association remained significant for individuals with high SUA levels (p-value ≤ 0.01). The association between SUA and BMD was not significant in non-obese, females, young adults, and smokers. However, no interaction was found between SUA and age, gender, BMI and smoking. Conclusion Higher SUA levels are associated with a high bone density among healthy Qatari adults. However, such observation demands further investigations to outline the underlying mechanisms.
Automatically Controlled Frequency-Tunable rf Plasma Thruster: Ion Beam and Thrust Measurements

A fast and automatically controlled frequency-tunable radiofrequency (rf) system is installed in an rf plasma thruster consisting of a stepped-diameter insulator source tube wound by a single-turn loop antenna and a solenoid providing a magnetic nozzle, and immersed in vacuum. The frequency and the output power are controlled so as to minimize the reflection coefficient and to maintain the net power corresponding to the forward minus reflected powers at a constant level. The reproducibility of the impedance matching and the stability of the net rf power are assessed, showing the fast impedance matching within about 10 msec and the long and stable delivery of the rf power to the thruster. When increasing the rf power up to 500 W, discontinuous changes in the source plasma density, the imparted thrust, and the signal intensity of the ion beam downstream of the thruster are observed, indicating effects of the discharge mode on the thruster performance and the ion energy distribution.
Application of the Educational Game to Enhance Student Learning

The purpose of this study is to investigate the use of an educational game to enhance student learning effectiveness. This study consisted of 56 college students majoring in physical education and recreation management (32 men, 24 women, age M = 21 years, SD = 1.72). Students used the educational computer game “PaGamO” to study the motor learning and development course. Students received rewards based on their individual and group “PaGamO” scores. Regression analysis indicated that “PaGamO” score was a significant (p < 0.01) predictor of multiple choice (MC) score in the final examination, there was a medium positive correlation (β = 0.354). The R2 suggests that 12.6% of MC score was explained by “PaGamO” score. Quantitative and qualitative mixed-method approach was used to gain insights into students’ perceptions and experiences of the educational game. The top three statements of a modified questionnaire from Riemer and Schrader (2015) are: (1) “In my opinion, the use of ‘PaGamO’ enables me to better prepare for the final examination” (M = 5.04, SD = 1.41), (2) “In my opinion, the use of ‘PaGamO’ enables me to understand learning contents” (M = 4.8, SD = 1.19), (3) “In my opinion, the use of ‘PaGamO’ allows me to apply knowledge” (M = 4.75, SD = 1.08). The top three motives to play “PaGamO” were “fun,” “self-learning,” and “want to get a higher grade in the final examination. ” By using gamification as a tool for learning and studying, students did find “PaGamO” effective for their learning experience. Both intrinsic and extrinsic participation motives are reasons why students play “PaGamO. ” Furthermore, due to its convenience, using mobile devices to play “PaGamO” is more popular than using computers and tablet devices. In conclusion, the combination of gamification and traditional learning methods can enhance students’ learning outcomes.
The Influence of Structure on the Physico-chemical Properties of Slags.

The current knowledge of the structures of silicate slags is summarised and the relationships between measures of the depolymerisation of the melt and various physical properties are examined. It is shown that the optical basicity when corrected for the cations required to charge-balance any AlO45- tetrahedra present, provides a reasonable measure of the depolymerisation of the melt and has the advantage over the (NBO/T) ratio that it compensates for cation effects. It is shown that the depolymerisation of the melt is the primary factor affecting most physical properties, the cations having only a secondary effect. The relationships between structure and the viscosity, electrical and thermal conductivity, diffusion coefficient, density, thermal expansion coefficient, thermodynamic and optical properties of melts are discussed.
Greener Approach towards Corrosion Inhibition

Corrosion control of metals is technically, economically, environmentally, and aesthetically important. The best option is to use inhibitors for protecting metals and alloys against corrosion. As organic corrosion inhibitors are toxic in nature, so green inhibitors which are biodegradable, without any heavy metals and other toxic compounds, are promoted. Also plant products are inexpensive, renewable, and readily available. Tannins, organic amino acids, alkaloids, and organic dyes of plant origin have good corrosion-inhibiting abilities. Plant extracts contain many organic compounds, having polar atoms such as O, P, S, and N. These are adsorbed on the metal surface by these polar atoms, and protective films are formed, and various adsorption isotherms are obeyed. Various types of green inhibitors and their effect on different metals are mentioned in the paper.