Miracle-dz/UniFAR-FTUs huggingface dataset:
Food safety control strategies: A critical review of traditional approaches

The development of effective and efficient infrastructures for ensuring the production, processing, preparation and service of wholesome food is an indispensable element in the achievement of the goals of health for all. There is sufficient literature on microbiological hazards of food and the factors which influence their occurrence, growth and multiplication in foods. Similarly, risk of practices, procedures and processes which often lead to outbreaks of food‐borne diseases are known. Epidemiological evidence has shown that these factors are more or less the same in most countries of the world. But in spite of the availability of this wide range of information, food‐borne diseases continue to place a heavy strain on scarce economic resources in addition to causing significant morbidity and mortality in human populations. This calls for a profound rethink of the potential effectiveness and contribution of traditional approaches to food safety control, and a more enthusiastic acceptance and implementation.
The Role of Iodine for Thyroid Function in Lactating Women and Infants

Abstract Iodine is a micronutrient needed for the production of thyroid hormones, which regulate metabolism, growth, and development. Iodine deficiency or excess may alter the thyroid hormone synthesis. The potential effects on infant development depend on the degree, timing, and duration of exposure. The iodine requirement is particularly high during infancy because of elevated thyroid hormone turnover. Breastfed infants rely on iodine provided by human milk, but the iodine concentration in breast milk is determined by the maternal iodine intake. Diets in many countries cannot provide sufficient iodine, and deficiency is prevented by iodine fortification of salt. However, the coverage of iodized salt varies between countries. Epidemiological data suggest large differences in the iodine intake in lactating women, infants, and toddlers worldwide, ranging from deficient to excessive intake. In this review, we provide an overview of the current knowledge and recent advances in the understanding of iodine nutrition and its association with thyroid function in lactating women, infants, and toddlers. We discuss risk factors for iodine malnutrition and the impact of targeted intervention strategies on these vulnerable population groups. We highlight the importance of appropriate definitions of optimal iodine nutrition and the need for more data assessing the risk of mild iodine deficiency for thyroid disorders during the first 2 years in life.
Global Warming Could Magnify Insect-Driven Apparent Competition Between Native and Introduced Host Plants in Sub-Antarctic Islands

Abstract Pristine sub-Antarctic islands terrestrial ecosystems, including many endemic species, are highly threatened by human-induced cosmopolitan plant invasion. We propose that native plant suppression could be further facilitated by the subsequent invasion by generalist pest species that could exacerbate their competitive exclusion through the process of apparent competition. By comparing the biological parameters of an invasive aphid species, Myzus ascalonicus, on one native (Acaena magellanica) and one invasive (Senecio vulgaris) plant species, we showed that survival and fecundity were higher and development time lower on the native plant species than on the invasive one. Moreover, comparing the effect of a temperature increase on the population dynamics of M. ascalonicus on the two plants, we showed that the relative profitability of the native species is further amplified by warming. Hence, while pest population doubling time is 28% higher on the invasive plant under current temperature, it would become 40% higher with an increase in temperature of 3°C. Consequently, our findings demonstrate that global warming could exacerbate competitive exclusion of native plants by invasive plants in sub-Antarctic islands by its indirect effect on the apparent competition mediated by generalist phytophagous pests.
An interactive on-line multi-objective optimization approach with application to metal cutting turning operation

An on-line supervisory computer control model for optimization of multiple objective programming problems is developed and applied to machining problems. Specifically, the turning operation is formulated and solved by the approach. For the first time, the characteristics of on-line multi-objective problems are described and an approach for solving such problems is developed. The proposed system maintains feasibility of operations and optimizes objectives based on the machine performance and on-line interactions with the decision-maker (DM). The model is hierarchical and consists of two levets: level 1 is designed to protect automated machinery and the workpiece by monitoring the process outputs; and level 2 is designed to optimize the on-line multi-objective problem. The tasks of both levels are accomplished by on-line monitoring and control of changes in process outputs via real-time information provided by sensors. The recommended parameters, obtainable from the multi-objective optimization approach, ar.
Experimental Identification of a Shear-Mode MR Damper and Numerical Evaluation of Hysteretic Models

Magnetorheological (MR) dampers have become an effective means for the semiactive vibration control of civil structures. For achieving good control performance, it is necessary to make the accurate characterization of the civil structures to be controlled, the sensors, the actuators and some other systems integrated. Nowadays, the modeling and identification of the dynamics of an MR damper is still a challenging task due to its highly hysteretic nonlinearities. This paper presents experimental results on the modeling and identification of a type of MR damper prototype whose MR fluid is contained in a foam. A comparative study is made among three parametric models (Bingham, Bouc-Wen and Hyperbolic tangent). Copyright © 2007 by ASME
Analysis of second moments and their budgets for Richtmyer-Meshkov instability and variable-density turbulence induced by reshock

Nonlinear Richtmyer–Meshkov instability and mixing transition induced by a Mach 1.45 shock and subsequent re-shock at an interface between two ideal gases (sulfur hexaﬂuoride and air) with high Atwood number are studied with second-moment analysis using data from high-resolution compressible Navier–Stokes simulations. The analysis ﬁrst addresses the importance of two second-order moments: turbulent mass ﬂux and density-speciﬁc-volume covariance, together with their transport equations. These quantities play an essential role in the development of Favre-averaged Reynolds stress and turbulent kinetic energy in this variable-density ﬂow. Then, grid sensitivities and the time evolution of the turbulent quantities which include the second-moments are investigated, followed by a detailed study of the transport equations for the second-moments including the Reynolds stress and the turbulent kinetic energy with well-resolved data before re-shock. After re-shock, budgets of the same but large-scale turbulent quantities are studied with the eﬀects of the subﬁlter-scale stress taken into account. The budgets of these large-scale quantities are shown to have an insigniﬁcant inﬂuence from the numerical regularization. Finally, the eﬀects of the subﬁlter-scale stress on the budgets of the large-scale turbulent quantities with diﬀerent degrees of ﬁltering are also examined.
Levels of Automation in Process Control

Although the Sheridan-Verplank Scale to describe levels and modes of human-machine interaction has existed for more than 20 years little systematic work has been done to evaluate the properties of the different levels. This paper describes the first stages of a program to compare Sheridan-Verplank level, system reliability, and quality of automated assistance on productivity, trust, operator self-confidence, and fault management in process control.
Myocardial blood flow is the dominant factor influencing cardiac magnetic resonance adenosine stress T2

Stress imaging identifies ischemic myocardium by comparing hemodynamics during rest and hyperemic stress. Hyperemia affects multiple hemodynamic parameters in myocardium, including myocardial blood flow (MBF), myocardial blood volume (MBV), and venous blood oxygen levels (PvO2). Cardiac T2 is sensitive to these changes and therefore is a promising non‐contrast option for stress imaging; however, the impact of individual hemodynamic factors on T2 is poorly understood, making the connection from altered T2 to changes within the tissue difficult. To better understand this interplay, we performed T2 mapping and measured various hemodynamic factors independently in healthy pigs at multiple levels of hyperemic stress, induced by different doses of adenosine (0.14‐0.56 mg/kg/min). T1 mapping quantified changes in MBV. MBF was assessed with microspheres, and oxygen consumption was determined by the rate pressure product (RPP). Simulations were also run to better characterize individual contributions to T2.
Precision targeting of the vagal anti-inflammatory pathway attenuates the systemic inflammatory response to burn injury

Directly targeting the alpha-7 nicotinic acetylcholine receptor decreases gut and lung inflammation in a burn injury model. Could this approach improve the clinical efficacy of prior pharmacologic vagal agonists? Supplemental digital content is available in the text. BACKGROUND The systemic inflammatory response (SIRS) drives late morbidity and mortality after injury. The α7 nicotinic acetylcholine receptor (α7nAchR) expressed on immune cells regulates the vagal anti-inflammatory pathway that prevents an overwhelming SIRS response to injury. Nonspecific pharmacologic stimulation of the vagus nerve has been evaluated as a potential therapeutic to limit SIRS. Unfortunately, the results of clinical trials have been underwhelming. We hypothesized that directly targeting the α7nAchR would more precisely stimulate the vagal anti-inflammatory pathway on immune cells and decrease gut and lung injury after severe burn. METHODS C57BL/6 mice underwent 30% total body surface area steam burn. Mice were treated with an intraperitoneal injection of a selective agonist of the α7nAchR (AR-R17779) at 30 minutes postburn. Intestinal permeability to 4 kDa FITC-dextran was measured at multiple time points postinjury. Lung vascular permeability was measured 6 hours after burn injury. Serial behavioral assessments were performed to quantify activity levels. RESULTS Intestinal permeability peaked at 6 hours postburn. AR-R17779 decreased burn-induced intestinal permeability in a dose-dependent fashion (p < 0.001). There was no difference in gut permeability to 4 kDa FITC-dextran between sham and burn-injured animals treated with 5 mg/kg of AR-R17779. While burn injury increased lung permeability 10-fold, AR-R17779 prevented burn-induced lung permeability with no difference compared with sham (p < 0.01). Postinjury activity levels were significantly improved in burned animals treated with AR-R17779. CONCLUSION Directly stimulating the α7nAchR prevents burn-induced gut and lung injury. Directly targeting the α7nAChR that mediates the cholinergic anti-inflammatory response may be an improved strategy compared with nonspecific vagal agonists.
Multiyear Factor VIII Expression after AAV Gene Transfer for Hemophilia A.

BACKGROUND The goal of gene therapy for patients with hemophilia A is to safely impart long-term stable factor VIII expression that predictably ameliorates bleeding with the use of the lowest possible vector dose. METHODS In this phase 1-2 trial, we infused an investigational adeno-associated viral (AAV) vector (SPK-8011) for hepatocyte expression of factor VIII in 18 men with hemophilia A. Four dose cohorts were enrolled; the lowest-dose cohort received a dose of 5 × 1011 vector genomes (vg) per kilogram of body weight, and the highest-dose cohort received 2 × 1012 vg per kilogram. Some participants received glucocorticoids within 52 weeks after vector administration either to prevent or to treat a presumed AAV capsid immune response. Trial objectives included evaluation of the safety and preliminary efficacy of SPK-8011 and of the expression and durability of factor VIII. RESULTS The median safety observation period was 36.6 months (range, 5.5 to 50.3). A total of 33 treatment-related adverse events occurred in 8 participants; 17 events were vector-related, including 1 serious adverse event, and 16 were glucocorticoid-related. Two participants lost all factor VIII expression because of an anti-AAV capsid cellular immune response that was not sensitive to immune suppression. In the remaining 16 participants, factor VIII expression was maintained; 12 of these participants were followed for more than 2 years, and a one-stage factor VIII assay showed no apparent decrease in factor VIII activity over time (mean [±SD] factor VIII activity, 12.9±6.9% of the normal value at 26 to 52 weeks when the participants were not receiving glucocorticoids vs. 12.0±7.1% of the normal value at >52 weeks after vector administration; 95% confidence interval [CI], -2.4 to 0.6 for the difference between matched pairs). The participants had a 91.5% reduction (95% CI, 88.8 to 94.1) in the annualized bleeding rate (median rate, 8.5 events per year [range, 0 to 43.0] before vector administration vs. 0.3 events per year [range, 0 to 6.5] after vector administration). CONCLUSIONS Sustained factor VIII expression in 16 of 18 participants who received SPK-8011 permitted discontinuation of prophylaxis and a reduction in bleeding episodes. No major safety concerns were reported. (Funded by Spark Therapeutics and the National Heart, Lung, and Blood Institute; ClinicalTrials.gov numbers, NCT03003533 and NCT03432520.).
Epitranscriptomics of cardiovascular diseases (Review)

RNA modifications have recently become the focus of attention due to their extensive regulatory effects in a vast array of cellular networks and signaling pathways. Just as epigenetics is responsible for the imprinting of environmental conditions on a genetic level, epitranscriptomics follows the same principle at the RNA level, but in a more dynamic and sensitive manner. Nevertheless, its impact in the field of cardiovascular disease (CVD) remains largely unexplored. CVD and its associated pathologies remain the leading cause of death in Western populations due to the limited regenerative capacity of the heart. As such, maintenance of cardiac homeostasis is paramount for its physiological function and its capacity to respond to environmental stimuli. In this context, epitranscriptomic modifications offer a novel and promising therapeutic avenue, based on the fine-tuning of regulatory cascades, necessary for cardiac function. This review aimed to provide an overview of the most recent findings of key epitranscriptomic modifications in both coding and non-coding RNAs. Additionally, the methods used for their detection and important associations with genetic variations in the context of CVD were summarized. Current knowledge on cardiac epitranscriptomics, albeit limited still, indicates that the impact of epitranscriptomic editing in the heart, in both physiological and pathological conditions, holds untapped potential for the development of novel targeted therapeutic approaches in a dynamic manner.
Comprehensive DNA repair gene expression analysis and its prognostic significance in acute myeloid leukemia

ABSTRACT Background Deficiency in DNA damage response (DDR) pathway and accumulation of DNA damage increases mutation rates resulting in genomic instability and eventually increases the risk of cancer. The aim of our study was to investigate expressions of DNA repair genes as new prognostic biomarkers in acute myeloid leukemia (AML). Methods We utilized The Cancer Genome Atlas AML project (TCGA-LAML cohort, 15 acute promyelocytic leukemia (APL) and 155 non-APL AML) for the expression data of DNA repair genes. For validation, clinical samples (Ewha study group, 9 APL and 72 non-APL AML patients) were analyzed for the expression of 22 DNA repair genes using a custom RT2 Profiler PCR Array. Results APL patients presented significantly lower expression of DNA repair genes than non-APL AML patients in both study groups. Among non-APL AML patients, high expression levels of PARP1, XRCC1, and RAD51 were associated with poor overall survival (OS) probability in both study groups. Furthermore, Cox regression analysis showed that increased expression levels of PARP1, XRCC1, RAD51, BRCA1 and MRE11A could be independent risk factors for OS in the Ewha study group. Among non-APL patients of the Ewha study group, the OS probability of DDR-overexpressed group with at least one gene or more showing Z score greater than 1.5 was poorer than that of DDR non-overexpressed group. Conclusion In the current study, the DNA repair gene expression profile of APL patients was different from that of non-APL AML patients. Overexpression of DNA repair genes could be a poor prognostic biomarker in non-APL AML.
Risk and protective factors for mental health outcomes among sexual minority and heterosexual college women and men

Abstract Objective: Understand the relationship between risk factors (eg, different sexual assault types – coercive, physical, incapacitation by alcohol/drugs) and protective factors (eg, strong maternal ties) with depressive symptoms and post-traumatic stress disorder (PTSD) symptoms among college students. Participants: Six hundred twenty-five undergraduate students. Methods: Students completed paper and pencil surveys in fall 2019 at a large public university. Results: Risk factors of child physical and sexual abuse, all three sexual assault types, and combined sexual assault were associated with greater PTSD symptoms while maternal relationship quality and religious influence served as protective factors. Risk factors of child physical and sexual abuse, coercive sexual assault, and combined sexual assault were associated with depressive symptoms while maternal relationship quality served as a protective factor. Males who identified as sexual minority (SM) had more PTSD symptoms compared to females who identified as SM. Conclusions: Findings have implications for targeted interventions to improve mental health outcomes.
Spatial and temporal intracerebral hemorrhage patterns in Dutch-type hereditary cerebral amyloid angiopathy

Aim To investigate whether there is a topographical and temporal pattern of index and recurrent intracerebral hemorrhages (ICH) in Dutch-type hereditary Cerebral Amyloid Angiopathy (D-CAA) to increase our understanding on CAA-related ICH development. Methods We included patients with DNA confirmed D-CAA or a history with ≥1 lobar ICH and ≥1 first-degree relative with D-CAA. Topographical pattern was studied by location (proportion frontal/parietal/temporal/occipital; infra/supratentorial and occurrence ratios relative to lobe volume) and volume of index and recurrent ICHs were determined on CT. Temporal pattern was examined by time between recurrent ICHs was retrieved from medical records. Results We included 72 patients with D-CAA (mean age at index ICH 55 years) with in total 214 ICH. The median follow-up time was 7 years (range 0.8 to 28 years). All ICH were lobar and supratentorial. The index ICH was most frequently located in the occipital lobe (34% vs. 22% in the other three lobes; with index ICH occurrence ratios relative to lobe volume of 1.9 for occipital, 1.0 for temporal, 1.2 for parietal, and 0.5 for frontal, p = 0.001). In 16/47 (34%) patients with multiple ICH, the second ICH was located in the same lobe as the index ICH. The median time-interval between subsequent ICH was #1-2 ICH 27 months, #2-3 ICH 14 months, and #3-4 ICH 7 months (p = 0.6) There was no difference in volume between index and recurrent ICHs. Conclusions We found that index and recurrent ICHs in D-CAA have a preference for the occipital lobe and are least frequent in the frontal lobe, which adds to the existing knowledge of histopathological studies on amyloid load in CAA. Surprisingly, there was no acceleration in time nor gradual increase of hematoma volume between subsequent ICHs.
Correlation-enhanced stability of microscopic cyclic heat engines

For cyclic heat engines operating in a finite cycle period, thermodynamic quantities have intercycle and intracycle correlations. By tuning the driving protocol appropriately, we can get the negative intercycle correlation to reduce the fluctuation of work through multiple cycles, which leads to the enhanced stability compared to the single-cycle operation. Taking the Otto engine with an overdamped Brownian particle as a working substance, we identify a scenario to get such enhanced stability by the intercycle correlation. Furthermore, we demonstrate that the enhancement can be readily realized in the current experiments for a wide range of protocols. By tuning the parameters within the experimentally achievable range, the uncertainty of work can be reduced to below $\sim 50 \%$.
Beirut Explosion: The Largest Non-Nuclear Blast in History

Abstract A massive explosion have ripped Beirut on August 4, 2020, leaving behind more than 6000 casualties, 800 regular floor admissions, 130 intensive care unit admissions, and over 200 deaths. Buildings were destroyed, hospitals in Beirut were also destroyed, others became nonfunctional. A disaster code was initiated in all the hospitals. Victims were transported by the Lebanese Red Cross or by volunteers to the nearest hospital that was still functional. Hospitals were flooded in patients, the coordination between health care centers was missing. Each hospital was functioning to its maximum capacity. With the many challenges we had, a rapid response was initiated. An effective triage done outside the Emergency had the major role in saving lives. After the Beirut Explosion, an assessment of the disaster plan and a major evaluation of the hospitals’ coordination is needed.
Broad impacts of COVID-19 pandemic on acute respiratory infections in China: an observational study

Abstract Background To combat the COVID-19 pandemic, nonpharmaceutical interventions (NPI) were implemented worldwide, which impacted a broad spectrum of acute respiratory infections (ARI). Methods Etiologically diagnostic data from 142 559 cases with ARIs, who were tested for eight viral pathogens (influenza virus, IFV; respiratory syncytial virus, RSV; human parainfluenza virus, HPIV; human adenovirus; human metapneumovirus; human coronavirus, HCoV; human bocavirus, HBoV, and human rhinovirus, HRV) between 2012 and 2021, were analyzed to assess the changes of respiratory infections in China during the first COVID-19 pandemic year compared to pre-pandemic years. Results Test positive rates of all respiratory viruses decreased during 2020, compared to the average levels during 2012−2019, with changes ranging from -17·2% for RSV to -87·6% for IFV. Sharp decreases mostly occurred between February and August when massive NPIs remained active, although HRV rebounded to the historical level during the summer. While IFV and HMPV were consistently suppressed year round, RSV, HPIV, HCoV, HRV HBov resurged and went beyond historical levels during September, 2020−January, 2021, after NPIs were largely relaxed and schools reopened. Resurgence was more prominent among children younger than 18 years and in Northern China. These observations remain valid after accounting for seasonality and long-term trend of each virus. Conclusions Activities of respiratory viral infections were reduced substantially in the early phases of the COVID-19 pandemic, and massive NPIs were likely the main driver. Lifting of NPIs can lead to resurgence of viral infections, particularly in children.