Miracle-dz/UniFAR-FTUs huggingface dataset:
The cost of evolved constitutive lac gene expression is usually, but not always, maintained during evolution of generalist populations

Abstract Beneficial mutations can become costly following an environmental change. Compensatory mutations can relieve these costs, while not affecting the selected function, so that the benefits are retained if the environment shifts back to be similar to the one in which the beneficial mutation was originally selected. Compensatory mutations have been extensively studied in the context of antibiotic resistance, responses to specific genetic perturbations, and in the determination of interacting gene network components. Few studies have focused on the role of compensatory mutations during more general adaptation, especially as the result of selection in fluctuating environments where adaptations to different environment components may often involve trade‐offs. We examine whether costs of a mutation in lacI, which deregulated the expression of the lac operon in evolving populations of Escherichia coli bacteria, were compensated. This mutation occurred in multiple replicate populations selected in environments that fluctuated between growth on lactose, where the mutation was beneficial, and on glucose, where it was deleterious. We found that compensation for the cost of the lacI mutation was rare, but, when it did occur, it did not negatively affect the selected benefit. Compensation was not more likely to occur in a particular evolution environment. Compensation has the potential to remove pleiotropic costs of adaptation, but its rarity indicates that the circumstances to bring about the phenomenon may be peculiar to each individual or impeded by other selected mutations.
Analisis Pengaruh Budaya Organisasi dan Pengendalian Internal terhadap Kinerja Pegawai

This paper intends to ascertain whether the influence of organizational culture and internal control on employee performance. An organization can be said to be successful if it is supported by good employee performance. Organizational culture that has long been built in the organization can certainly have an influence on the behavior of employees in it. Likewise with internal control, the better the internal control function in an organization, the employee's performance will also increase in a better and maximum direction. The data used are primary data, namely by distributing questionnaires to collect data. The research sample was ASN in the Environmental Service of North Sulawesi Province. Methods of data analysis using multiple regression. The results of this study indicate that the organizational culture variable (X1) has a significance value = 0.000 <? = 0.05, so it can be concluded that organizational culture has an effect on employee performance. Furthermore, for the test results on the Internal Control variable (X2) on Employee Performance (Y) has a significance value = 0.028 <? = 0.05, which means that Internal Control also affects employee performance. Organizational culture that is not conducive will cause employee performance to decline. However, if the organization, in this case the public sector, is able to build a good organizational culture, it will be able to improve employee performance. Likewise with internal control, the better internal control within an organization, the better the employee's performance in the organization. So that when control and supervision have been carried out properly and have been implemented by employees, the employee's performance will automatically increase.
The Role of User’s Attitude Mediating The Effect of Perceived Ease of Use and Social Influence towards The Continuance Usage Intention of TikTok

TikTok is becoming a global phenomenon due to its popularity and the fastest-growing apps globally. This application’s user growth is increasing very fast, that it reached as many as 200 million downloads. This study examines seven research questions to determine how attitude mediating the effect of perceived ease of use and social influence towards the continuance usage intention of TikTok. To validate the research model, the author used an online survey instrument by Google Form to collected data. Partial Least Squares Modeling was used to test the hypotheses. The findings reveal users' attitude determines that continued intention to use the TikTok application; attitude is affected by perceived ease of use and social influence, and both perceived ease of use and social influence affected the continuance usage intention of TikTok application.
The Inhibition of Proliferation and Invasion of Human Colon Carcinoma Cell Line (Caco-2 cells) by Cell-free Supernatants from Lactobacillus Rhamnosus and Lactobacillus Acidophilus

Background: The epidemiological studies indicated that colorectal cancer is one of the most common types of cancer in the world and is considered a leading cause of cancer-related death. The present study aimed to investigate the inhibitory effect of lactobacillus acidophilus supernatant (LAS) and lactobacillus rhamnosus supernatant (LRS) on the growth and invasiveness of the human colon carcinoma cell line (Caco2) in-vitro. Methods: In this experimental study, the anti-proliferative activity and anti-invasion potential of LAS and LRS were determined by MTT and transwell chambers assays, respectively. The expression of mitochondrial membrane potential-9 (MMP-9) and matrix metalloproteinase-12 (MMP12) genes were analyzed by real-time PCR.Results: The results indicated that supernatants of these two lactobacilli had cytotoxic effects on Caco-2 cells at a concentration of 25% v/v and higher. Thus, the minimum concentrations (25% V/V) of supernatants were chosen for further experiments. LAS and LRS could significantly suppress the invasiveness of Caco-2 cells. Also, the expression of MMP12 was significantly increased in Caco-2 cells when treated with LAS, whereas LRS had no significant effect on the invasive capacity and the gene expression levels of MMP12. The expression of MMP-9 was statistically decreased in Caco2 cells treated with LAS and LRS (P<0.00001). Conclusion: In general, it was shown that LAS and LRS exert anti-cancer activity against the growth, invasion, and metastasis of Caco2 cells in-vitro. It seems that these two bacteria could be used as prophylactic and therapeutic agents for the prevention and treatment of colorectal cancer.
Research of the Impact of Financial Dimensions and Entrepreneurial Capacity on Business Performance in Small and Medium Enterprises in Central Java

Background: The number of Indonesian SME units in 2018 was 99.9% of the total business units (62.9 million units), absorbing 97% of the total employment and contributing 60% to GDP. However, two fifth of Indonesia SMEs has internal and external capital and financial acquisition constraints. Purpose: Based on the entrepreneurship and finance theories, this study aims to analyze the influence of the entrepreneurship capability on improving the business performance of a Central Java fashion industry of batik SMEs with the mediating effect of financial dimension. Methodology: Types of data used in this study are primary data and secondary data. The study population was the owner of the SME batik business in Pekalongan, Central Java. The sampling technique was non-probability sampling with a purposive sampling approach of saturated sampling. Principal results: The results showed that the entrepreneurship capability and the internal financial dimension had a positive effect on the business performance of the batik SMEs, while the external financial dimension had a negative effect on the business performance. Moreover, the internal financial dimension was able to mediate the entrepreneurship capability on the business performance of the batik SMEs. Major conclusions: The improvement in the performance of batik SMEs is influenced by the entrepreneurship capability and it will increase if it is mediated by the internal financial dimension. Contributions to the field: There are research contributions of this study, by exploring the indicators from the funding dimension variable and indicators from the entrepreneurship capability variable from a psychological side. Important aspects of the study: What makes this research different from previous researches is that the independent variables used and the research object are different and broader.
Students’ perceived learning in physical education: variations across students’ gender and migration background in Sweden

ABSTRACT Students’ perceived learning in physical education (PE) is an important yet neglected area of research. Increased knowledge about students’ perceived learning can provide teachers with useful information to promote meaningful learning experiences in PE. Moreover, perceived learning can potentially be an alternative measurement to school grades when analyzing equality of outcome. Given that gender and migration background are associated with equality issues in PE, these groups are of particular focus in this study. With this background, the aim of this paper is threefold: (a) to explore students’ perceived learning in PE in Sweden, (b) to analyze what perceptions of PE are most prominent, and (c) present a way to quantitatively illustrate how perceptions about PE vary across gender and migration background. The analysis was based on a question about students’ perceived learning and was conducted in two steps. First, the students’ answers were categorized using qualitative content analysis. The analysis shows that the perceived learning in PE can be categorized into the following categories: ‘Physical doing’, ‘Emotional experiences’, ‘Health’, ‘Do not learn’, ‘Outdoor Education’ and ‘Social interaction’. Second, by quantitatively illustrate all answers in relation to the six categories, the result showed that the category of ‘Physical doing’ (36%) was the most prominent, and thereafter, in descending order are the categories of ‘Emotional experiences’ (22%), ‘Health’ (18%), ‘Do not learn’ (10%), ‘Outdoor Education’ (10%) and ‘Social interaction’ (4%). The results also showed that regardless of gender and migration background, students have somewhat similar perceptions of what they learn in PE. In this study we: (i) present a categorization of students’ perceived learning in PE, (ii) show that physical doing is a prominent aspect in students answers, lastly (iii) by quantitatively illustrate students’ perceived learning in PE, this study also suggest an alternative measurement to analyze equality in PE.
Monosex male formation of juvenile redclaw crayfish using natural steroid hormone from gamma sea cucumber and different doses of honey bee

In a new commercial commodity aquaculture, tropical freshwater crayfish Cherax quadricarinatus, it is known that female has a slower growth rate than male. One way to increase production rate is through monosex cultures comprising all-male population by using genital reversion technique. This biotechnology method can be applied by using hormones and natural products. The natural hormones extracted from gamma sea cucumber, Stichopus variegatus has bioactive substances including steroid compounds, while honey bee contains chrysin compounds that act as aromatase inhibitors. Therefore, the combination of both substances expected can increase in testosterone level and accelerate production in the male monosex population of juvenile crayfish. The purpose of the study is to determine the most effective dose of honey bee in masculinization of juvenile freshwater crayfish combined with 2 mg. L−1 steroid extract of gamma sea cucumber. Furthermore, a Completely Randomized Design (CRD) was designed in the experiment with five different dose of honey bee treatment and dipping method in 2 mg. L−1 steroid extract of gamma sea cucumber for 18 h. Each treatment with four replications. The highest male formation was found in the dose of 20 ml. L− 1 honey bee at 83.75% and the lowest was in control. The present of honey bee at different doses in 2 mg. L−1 of gamma steroid extract did not significantly give an effect on percentage of female, intersex formation, survival, and growth rate of juvenile redclaw crayfish.
Blockchain based Access Control and Data Sharing Systems for Smart Devices

Internet-of-Things and Blockchain technology are evolving all around today’s modern world to solve many problems such as security, communications, data collection and analysis, etc. However, we also have some issues, such as efficient data sharing, restriction of access, reliable authentication, etc. The proposed framework is designed to solve the problems related to security and authorization in IoT network access control. In addition, the system’s aim is to accomplish security, authorizing, and encryption for information exchange through IoT networks. In this article, a novel system is introducing to provide the data sharing system that integrates blockchain based access control system for IoT devices. Here, we are creating three different smart contracts to offers an efficient access control management like contract to provide access control, contract to provide authentication, and contract to provide a judgment. Finally, the effectiveness of the proposed approach is measured against the cost consumption of smart contracts and cryptographic functions. The cost utilization comparison is carried out against certain current approaches as well as the findings clearly demonstrate that the proposed approach is cost-effective.
Hybrid feature selection model based on relief‐based algorithms and regulizer algorithms for cancer classification

Cancer is a group of diseases that involve abnormal cell growth with the potential to spread to other parts of the body. Cancer microarray data usually include a small number of samples with a large number of gene expression levels as features. Gene expression or microarray is a technology that monitors the expression of the large number of genes in parallel that make it useful in cancer classification, high dimensionality in cancer microarray data results in the overfitting problem. This article proposes novel hybrid feature selection model called the RBARegulizer model, which is based on two types of feature selection techniques, two RBAs algorithms (ReliefF, MultiSURF) for feature‐ranking filters to the most important one's genes, and three regulizer algorithms (Lasso, Elastic Net, Elastic Net CV) to reduce the feature subset, remove the noisy and irrelevant feature to improve the performance and accuracy of cancer (microarray) data classification. For evaluating the model, the different three classifiers SVM, MLP, and random forest with four high‐dimensional microarray data for different cancer types were applied. The experimental type shows that our model overcomes the overfitting problem of cancer microarray data. Moreover, the results show that RBARegulizer model is perfect in improving the accuracy of cancer microarray data classification.
Individual structural MRI abnormality indexes are associated with molecular, histological and cognitive indicators for frontal glioma patients

Purpose: The conventional examination of molecular characteristics for glioma requires surgical removal and could not be used in the surgery planning. The aim is to develop a method previewing glioma malignancy with regular structural MRI images. Methods: 52 glioma patients in frontal lobe (mean age 43.2±9.3 years, 34 male) and 117 healthy controls (mean age 32.6±9.8 years, 83 male) participated in the study. All patients underwent neurocognitive test and molecular examinations, including 1p/19q co-deletion, isocitrate dehydrogenase (IDH) mutation, telomerase reverse transcriptase (TERT) promoter mutation and O6-methylguanine-DNA methyltransferase (MGMT) promotor methylation. A series of individual structural abnormality indexes based on preoperative structural MRI were proposed and explored the associations with these clinical indicators.Results: Individual structural abnormality maps displayed that bilateral hippocampus, parahippocampus, insula, putamen and thalamus were constantly affected by glioma regardless of the histological grade, tumor hemisphere and molecular status. Higher grade glioma patients suffered more structural abnormalities, especially in the contralateral hemisphere and non-tumor regions. The molecular indicators, including IDH1 mutation, 1p/19q co-deletion, TERT promoter mutations and MGMT promoter methylation, as well as neurocognitive performance were all significantly correlated to individual structural abnormality indexes.Conclusion: Our proposed individual structural abnormality indexes show great potentials to access the glioma pathological, neurocognitive and molecular indicators, which is very helpful for neurosurgeons to determine the personalized treatment strategies.
Adaptation of The N170-Component of the Event-Related Brain Potential to Single Letters and Words in Adults and Children

Background. Neural specialization for print develops during learning to read and can be studied with event-related brain potentials (ERPs). Neural adaptation refers to smaller neural responses when a stimulus or a class of stimuli is repeated several times. Previously, neural specialization for print processing in adults has been shown to be reflected in the word-specific N170 component of the ERP. Furthermore, adapation of the N170 elicited by words has been found to correlate with reading speed. Here, we investigated adapation of the N170-component evoked by single letters, words and faces in seven to nine- year old German-language speaking children and in a group of adult normal readers. Results. For adults, we replicated previous reports of adaptation of N170-amplitude at posterior-temporal electrodes P7 and P8 for single letters and words. For children, we only observed adaptation of N170-amplitude for single letters. No adaptation of N170-amplitude was apparent for words. However, in both, children as well as adults, N170-adaptation did not correlate with measures of reading speed. For faces, that served as a non-linguistic control condition, no adaptation of N170 amplitude was observed. Conclusions. We conclude that adaptation of the word-specific N170 component of the ERP might be linked to increasing perceptual experience with letters and words.
Gasification of biomass in a circulating fluidized bed based calcium looping gasifier for hydrogen-enriched gas production: experimental studies

ABSTRACT This paper presents experimental studies of circulating fluidized bed based calcium looping gasification (CFB-CLG) system for producing hydrogen-enriched gas from biomass. The merit of this system is that it captures carbon dioxide (CO2) during the process using the inexpensive and easily available sorbent calcium oxide (CaO). The process also regenerates the sorbent internally and produces a relatively pure stream of CO2. A laboratory scale calcium looping gasification system based on a circulating fluidized bed was developed and tested. Experiments conducted to gasify sawdust in the CFB-CLG system shows that it could produce a gas with 81% hydrogen and CO2 as low as 5%. Exergy analysis of the calcium looping system is done and the efficiency is 78.77%.
Antioxidant potential and phenolic composition of white and red wines

Many "in vitro" and "in vivo" researches show, that wine, especially red one, contains natural phenolic antioxidants that have beneficial effects on our health. Polyphenols are not only important for the antioxidant properties but also influence the sensorial properties of wine. Antioxidant potential (AOP), contents of total and individual phenolic compounds (flavonoids, tannins and antocyanins), colour parameters and content of sulphur dioxide were determined in a number of Slovenian white and red wines of different vintages from 2001 to 2004. In the presented work AOP of wine, expressed as mol/l, was determined spectrophotometricaly at wavelength 517 nm using stable free radical DPPH• (1,1-diphenyl-2-picrylhydrazyl). Correlations between AOP and phenolic compounds were established. Content of total and individual phenols were found to be characteristic of the grape variety. In accordance with the literature data we confirmed that wines with greater content of total phenols had also significantly greater AOP. Slovenian red wines had significantly higher content of total and individual phenols, and consequently a higher AOP in comparison to white wines. Certain older wines (2001-2003) of different varieties investigated had higher AOP than younger (2004) what was more obvious in white wines than in red ones. In the red wines tested the correlations between AOP and phenolic compounds were in the following order: total phenols > flavonoids > tannins > anthocyanins. Cabernet Sauvignon contained the highest content of total phenols and had greater AOP than Refosk and Merlot. The best correlations for all investigated red wines of vintage 2004 were between AOP and flavonoids (R 2 =0.97) and total phenol content (R 2 =0.95). Correlations between AOP and tannins (R 2 =0.80) and anthocyanins content (R 2 =0.40) were worse. Mentioned correlations for white wines were as followed: total phenols > tannins > flavonoids. During the ageing of the bottled red wines the content of anthocyanins decreased and consecutively the intensity of colour as well as the hue of colour.
Zakat Digitalization: Effectiveness of Zakat Management in the Covid-19 Pandemic Era

This study aims to analyze the role of digitalization in zakat management during the Covid-19 pandemic. Furthermore, it also aims to analyze the strengths, weaknesses, opportunities, and threats of zakat digitization in Indonesia. The method used in this research is a qualitative method with a literature study and a SWOT analysis approach. Literature shows that using digital platforms to collect, manage, and distribute zakat is very useful, especially during the Covid-19 pandemic, because it provides much convenience for its users. However, digital platforms have weaknesses and threats both for zakat institutions and for muzaki and mustahik. To overcome these threats and weaknesses, zakat institutions can make various strategies by utilizing existing strengths and opportunities. This strategy is made so that the collection and distribution of zakat funds can be appropriately optimized and have a tremendous impact on the community's welfare, especially for the poor who are affected by Covid-19.
The presence of students identified as having special needs as a moderating effect on their classmates’ reading comprehension scores in relation to other major class composition effects

ABSTRACT This study investigates the impact of the presence of students identified as having special needs (SEN) on their classmates’ achievements in reading comprehension. Multi-level regression modelling was conducted with the data of more than 75,000 fourth graders of 4,937 classes in Austria. Students’ scores of reading comprehension were used as the dependent variable in the models. The number of students with SEN was used as the independent variable, besides other class-level predictors like the socio-economic status or the self-concept. To disentangle individual from classroom composition aspects, variables at the individual level were used as independent variables as well (gender, age, first language, number of books at home, socio-economic background, kindergarten attendance, and self-concept). Results show only a small relationship (Cohen’s d = −0.16) between the presence of students with special needs on their classmates’ national standard scores, in particular compared to other class-composition effects like socio-economic status or self-concept.