Miracle-dz/UniFAR-FTUs huggingface dataset:
Managerial Ability and Investors Protect: Test of Stimulating Decision-Making Functions by Devil's Advocate Theory

The efforts of the developers of capital market laws and regulations over the past years have been aimed at increasing the level of information transparency to create more symmetry between companies and shareholders so that they can be more attractive to investors to invest in the stock market. But given the interplay of individual characteristics of corporate decision-makers with the interests of shareholders and investors, it seems that focusing on behavioral functions in the area of promoting managerial ability can more effectively lead to increased protection of shareholder interests. The purpose of this study is to investigate the effect of management ability on the protection of investors based on the development of the theory of the devil's advocate. Therefore, the present study, using the structural equation modeling approach and partial least squares analysis (PLS), while fitting the model's desirability, examined the impact of management ability on protecting investors. In this study, in order to measure the in-field variable, ie protection of shareholders' interests, a researcher-made questionnaire was created through meta-analysis with the participation of 15 research experts. Then the criterion of Demirjan et al (2013) was used to measure managerial ability as an exogenous variable in partial least squares analysis. The researcher-made questionnaire was sent to 142 CEOs of companies listed on the Tehran Stock Exchange, and finally, after many follow-ups, 105 questionnaires were completed and returned and used as a final sample for analysis. After ensuring the acceptable fit of the measurement and structural models of the research, according to the theory of the devil's advocate, the results showed that the ability of management has a positive and significant effect on protecting the investors. Managerial ability, as one of the specialized decision-making capacities, puts the company on the path of effective interaction with stakeholders and provides the ground for investors to Protect in companies' priorities to gain their trust.
Myofibroblasts in Odontogenic Cysts and Tumors: An Immunohistochemical Study

Objective: The objective of this study was to assess immunohistochemically the presence of myofibroblasts both qualitatively and quantitatively in odontogenic cysts and tumors and to compare with the control cases of squamous cell carcinoma and to correlate the results with biologic behavior of these lesions. Materials and Methodology: Formalin-fixed, paraffin-embedded blocks of odontogenic cysts and tumors were retrieved from institutional archives. The sample size is 40; these include ten cases of odontogenic keratocyst (OKC) (n = 10), five cases of dentigerous cyst (n = 5), ten cases of solid ameloblastoma (n = 10), and five cases of unicystic ameloblastoma (n = 5). Ten cases of squamous cell carcinoma (n = 10) served as control. Sections were taken and stained immunohistochemically using alpha-smooth muscle actin for evaluation of myofibroblasts. The number of positive stromal cells was evaluated both for quantitative and qualitative analyses. Results: The present study showed that the mean number of myofibroblasts among the odontogenic cysts and tumors was higher in locally aggressive lesions such as OKC (23.79 ± 19.95), solid ameloblastoma (26.38 ± 17.00), and unicystic ameloblastoma (20.74 ± 14.86) which were comparable to squamous cell carcinoma (21.49 ± 9.76) when compared to benign lesions like dentigerous cyst which showed the least number of myofibroblasts (13.1 ± 7.71). Qualitatively, the staining intensity of myofibroblasts showed a significant variation within the same lesion and among different lesions. There was a distinct difference in the morphology, pattern of arrangement, and distribution of myofibroblasts among the studied lesions. Conclusion: We conclude that the increase in the number of myofibroblasts could be one of the contributory factors for the locally aggressive behavior of benign lesions such as ameloblastomas and OKCs. Further studies are suggested to understand the mechanism by which these important cellular elements exert their effects on stromal and epithelial tissue compartments.
Making the Switch: Experiences and Results from Converting a Biostatistics Course to Flipped and Online Formats for Public Health Students

Abstract The recent rise in online learning in statistics has made it essential for instructors to teach effectively in that modality. In this retrospective, we reflect on how online course content was added to an introductory statistics course in a graduate public health program and how it was updated over time based on student feedback and instructor experiences. The impetus for the inclusion of online learning as well as the consequences of specific implementations are discussed for hybrid and fully online class formats. We found that while online learning seemed to be beneficial as a whole for public health students learning health statistics, identifiable differences in the design or implementation of lectures, software demonstrations, online discussion, computer lab activities, active learning, and homework assignments had a substantial effect on learning outcomes and student satisfaction.
Influence of social media adoption on the performance of construction small and medium-sized enterprises (SMEs) in Abuja – Nigeria

PurposeThe purpose of this paper is to examine the influence of social media adoption on the performance of construction small and medium-sized enterprises (SMEs). Design/methodology/approachConstruction SMEs owners and managers in Nigeria were surveyed using questionnaires to gather data. Partial least square structural equation modeling (PLS-SEM) was employed to assess measurement reliability and validity, as well as the hypothesized paths provided in the conceptual model that formed part of the final conclusions.FindingsThe empirical finding showed that social media usage increased knowledge accessibility, reduced costs and improved customer relations and service for organizations. Overall, social media adoption was significantly and positively related to SMEs business performance. Also, the paper revealed that learning capability mediates the relationship between social media and SMEs performance.Research limitations/implicationsData for the study came from only one industry and one related line of business; thus, including more companies from different sectors or industries could be more interesting. The study's findings contributed to the growing body of knowledge about the impact of social media on the efficiency of businesses. Small and medium-sized businesses also need to understand and recognize the impact of social media on the organization's performance in order to achieve a long-term competitive edge from the adoption of social media.Practical implicationsAccording to the findings, small construction firms can benefit from marketing the brands through social media channels and improved learning capability. In terms of accessibility, cost savings and improved relationships with customers, research shows that social media promotion can be beneficial to businesses. A study like this has the potential to show how social media can help striving small businesses interact cost-effectively with customers all over the world, opening new doors for sales and continuous improvement.Originality/valueThe relationship between SME performance in Nigeria and the use of social media has received very little attention despite social media's promising potentials, particularly for small businesses. The authors hoped that this study will fill a gap in the authors' understanding of how social media affects the performance of small and medium-sized businesses (SMEs) in the construction industry.
Effects of the inclusion of oak tannins in a diet rich in linoleic acid on in vitro rumen biohydrogenation and fermentation in sheep

There is a lack void of knowledge about which of the many types of tannins might be more specific and useful, in practice, to interfere with rumen biohydrogenation (BH) and modulate the fatty acid (FA) profile of ruminant derived products without impairing diet utilization. Two in vitro assays with batch cultures of rumen microorganisms were conducted to analyze the effect of an oenological commercial extract of oak tannins, at a practical dose under farm conditions (2% DM), on the rumen BH and fermentation of a diet also supplemented with 2% DM of sunflower oil. In the first experiment (12 h incubations), freeze-dried ruminal digesta were analyzed for FA composition. In the second one (24 h incubations), rumen fermentation parameters and bacterial community were examined. The addition of 2% DM of the oak tannin extract proved (P<0.01) to be able to slightly reduce the concentration of 18:0 (-5.2%) and increase those of 18:2n-6, n-3 polyunsaturated FA (PUFA) and n-6 PUFA (by approx. +64%), while tended (P<0.10) to decrease trans-10 18:1 (-9%) and enhance trans-11 18:1 (+14%). These changes were accompanied by increases in the mean value of oddand branched-chain FA, as well as in some keto-FA concentrations (P<0.05). On the other hand, it had no significant effects on the rumen fermentation characteristics that were analyzed (e.g., gas production kinetic, extent of OM degradation, pH, or ammonia and VFA concentrations; P>0.10). Although positive, when explored at practical doses in terms of animal feeding, results on the use of tannins to modulate microbial BH are not as promising as initially expected. More research in this field is still necessary.
Self-Rated Health Status of Upper Secondary School Pupils and Its Associations with Multiple Health-Related Factors

Health is an essential part of any individual, and gains particular importance in youth, as a good health at this age is more likely to reduce health risks both in the short and long term. The aim of this study was to assess the impact of physical and contextual parameters on youths’ perceived health. A total of 919 adolescents completed questionnaires on self-rated health status, electronic media use, leisure time and club physical activity, alcohol and tobacco consumption, and back pain, as well as performed the German Motor Performance Test. Participants with very good health had significantly higher physical fitness, leisure time exercise, and participated in sports clubs more often than those with poorer health. Electronic media use was significantly higher for those with poor/very poor health. Future intervention programs to improve youth health status should not only focus on active lifestyle but might also consider the impact of socioenvironmental factors, such as daily media use.
Phase 1/2a study of the IRAK4 inhibitor CA-4948 as monotherapy or in combination with azacitidine or venetoclax in patients with relapsed/refractory (R/R) acute myeloid leukemia or lyelodysplastic syndrome.

7016 Background: CA-4948 is a novel oral inhibitor of interleukin-1 receptor-associated kinase 4 (IRAK4) and FLT3. IRAK4 is critical in triggering inflammation, oncogenesis, and survival of cancer cells. Genetic mutations in the splicing factors SF3B1 and U2AF1 drive overexpression of a highly active long isoform of IRAK4 and have been associated with disease progression and poor prognosis of high-risk myelodysplastic syndrome (HR-MDS) and acute myeloid leukemia (AML). Methods: This is an open-label, phase 1/2a dose escalation and cohort expansion trial (NCT04278768). In phase 1 Dose Escalation, patients with R/R AML or HR-MDS are treated with CA-4948 monotherapy. Phase 1b includes 2 arms of combination therapy: CA-4948 + azacitidine (AZA) and CA-4948 + venetoclax (VEN). The primary objectives of this study are to assess the safety, clinical activity, and identify the Recommended Phase 2 Dose (RP2D) of CA-4948 as monotherapy or in combination with AZA or VEN in R/R AML or HR-MDS. The Phase 2a Dose Expansion includes patients for CA-4948 monotherapy: R/R AML with FLT3 mutation, or AML and HR-MDS R/R to HMA with U2AF1 or SF3B1 mutations. Results: As of December 16th, 2021, 49 patients have been treated in the phase 1 portion, of whom 43 started by September 30th, allowing 2 on-study disease assessments. The median number of prior therapies was 2 (range 1-5). Four monotherapy dose levels of CA-4948 were tested (200 to 500 mg orally BID). No dose-limiting toxicities were observed at 200 mg and 300 mg BID. No Grade 4 or 5 treatment-related AEs (TRAEs) were reported, and all the TRAEs were manageable. Reversible, manageable Grade 3 rhabdomyolysis occurred in 1/26 (4%) patients at 300 mg BID, 2/17 (12%) at 400 mg BID, and 1/3 (33%) at 500 mg BID. RP2D was determined as 300 mg BID. Of 43 patients starting before Sept 30th, 2021, 14 had SF3B1, U2AF1 or FLT3 mutations and demonstrated more promising efficacy. In the 5 evaluable AML patients with spliceosome mutations, 40% reached CR/CRh (1 CR, 1 CRh), both with study duration >6 months. In the 7 spliceosome-mutated HR-MDS patients, 57% reached marrow CR, including 1 with RBC transfusion independence and 1 proceeding to HSCT. One of the three FLT3-mutated AML reached CR, and 2 became FLT3-negative. Among the 29 patients without SF3B1/U2AF1/FLT3 mutations, 1 reached CR and 2 PR. Phase 1b and Phase 2a are ongoing. RNA-seq on selected samples showed decrease in relative expression of IRAK4-long isoforms with response to CA-4948. Conclusions: CA-4948 is well tolerated and effective in heavily pretreated AML and HR-MDS patients, especially in those with U2AF1/SF3B1/FLT3 mutations. No dose-limiting myelosuppression was reported, suggesting CA-4948 may be a candidate for combination therapy. Accrual of Phases 1b and 2a is ongoing. Clinical trial information: 04278768.
Recent advances in thermally conductive polymer composites

Polymer matrix composites (PMCs) with high thermal conductivity (TC) play an important role in improving the heat dissipation capacity of a new generation of electronic devices, particularly for 5G and aviation applications. Over the last few decades, considerable efforts have been made in the fabrication of highly thermally conductive PMCs. Advances in the thermal conduction mechanism of polymer composites are induced to, and then commonly used thermally conductive fillers are presented. In the following, the factors affecting the TC of polymer composites are discussed in detail, including fillers, interfaces, polymer matrices and processing technologies. Special attention is paid to the thermally conductive fillers. Then, some application areas of thermally conductive polymer composites are introduced. Finally, the deficiencies and future development trends in this research field are put forward. It is expected that this review will provide some beneficial inspiration in improving the TC of PMCs.
Diabetic major amputation in Far North Queensland 1998-2008: what is the Gap for Indigenous patients?

OBJECTIVE To examine demographic and clinical characteristics of diabetic patients undergoing diabetes-related major amputation in Far North Queensland to identify those at risk. DESIGN A cohort was examined for differences between Indigenous and non-Indigenous groups in age, co-morbidities, indication for amputation and mortality. Attendance at the High Risk Foot Service was also reported. SETTING Far North Queensland. PARTICIPANTS individuals with major amputations between 1998 and 2008. MAIN OUTCOME MEASURES Diabetes-related major amputations and mortality. RESULTS Of the 143 individuals who underwent major amputation during the study period, 52% were Indigenous. On average, Indigenous amputees were 14 years younger than non-Indigenous amputees. There were more female Indigenous amputees compared with Indigenous male amputees. Indigenous amputees were more likely to suffer from chronic kidney disease (P < 0.000) and reside in a remote community (P < 0.000). Sepsis as an indication for amputation was more frequent in Indigenous subjects (P = 0.019). There was no statistically significant difference in mortality related to the procedure between Indigenous and non-indigenous amputees. CONCLUSION Indigenous patients with renal disease living in remote communities are at higher risk of developing limb-threatening diabetic foot complications. Further improvements in self-care, diabetes management and foot-care are required to reduce major amputation rates, particularly for those residing in remote areas.
Development and Validation of Filial Piety Representations at Parents’ End of Life Scale

Filial piety has a long historical standing in Chinese communities. However, the filial piety practices of adult children at the end of a parent’s life are under-explored. This study aims to develop a measurement for filial piety representations of the adult children of Macao Chinese, whose parents are at the stage of end of life. By adopting a scale development and validation framework, a 19-item Filial Piety Representations at Parents’ End of Life Scale (FPR-EoL) was formulated based on a Dual Filial Piety Model and literature, through procedures of item identification, panel review, cognitive interviews, and pre-test. The FPR-EoL was examined on 274 individuals. Factor analysis showed four factors in the scale; respect and comfort, acceptance of death, spending final days, and disclosing bad news. The Cronbach’s alpha of FPR-EoL was 0.73, and the four factors were 0.73, 0.66, 0.58 and 0.77, respectively. Discriminant validity was examined between FPR-EoL, the Good Death Inventory (GDI) and the Filial Piety Scale (FPS). The results suggested that there were differences between the three scales. FPR-EoL is found to be a reliable, valid and novel measure of filial piety representations among Macao Chinese. It may be a potential tool to probe and achieve good death among older persons of Chinese ethnicity in clinical settings.
Unsur Perbuatan Melawan Hukum dalam Kasus Pembuatan Akta Pendirian Yayasan oleh Notaris

Dalam pelaksanaan tugas jabatan notaris dalam pembuatan akta otentik tidak sesuai dengan ketentuan dalam UUJN dan Kode Etik Jabatan Notaris. Sehingga terjadi sengekta antara para pihak/pengahadap, notaris turut terkena dampak dari sengekta tersebut. Seperti dalam kasus dugaan perbuatan melawan hukum pemalsuan dalam pembuatan akta pendirian yayasan berdasarkan putusan Pengadilan Tinggi Aceh Nomor: 95/Pdt/2019.Pt. Bna. Penelitian ini bertujuan untuk menjelaskan tentang unsur perbuatan melawan hukum yang dilakukan oleh notaris dalam pembuatan akta pendirian yayasan berdasarkan putusan Pengadilan Tinggi Aceh Nomor: 95/Pdt/2019.Pt. Bna. Penelitian hukum normatif, pendekatan peraturan perundang-undangan (statute approach), pendekatan kasus (case approach). Hasil penelitian ini menyimpulkan bahwa perbuatan Notaris Annisa Rahmah Karim dalam membuat akta pendirian Yayasan Dayah Bustanul Ulum memenuhi unsur-unsur Perbuatan melawan hukum yang diatur dalam Pasal 1365 KUHPerdata dan bertentangan dengan Pasal 15 angka (1) Undang-Undang Yayasan serta Pasal 2 angka (2) Peraturan Pemerintah (PP) Nomor 63 Tahun 2008.
Effective Conversion of a Convolutional Neural Network into a Spiking Neural Network for Image Recognition Tasks

Due to energy efficiency, spiking neural networks (SNNs) have gradually been considered as an alternative to convolutional neural networks (CNNs) in various machine learning tasks. In image recognition tasks, leveraging the superior capability of CNNs, the CNN–SNN conversion is considered one of the most successful approaches to training SNNs. However, previous works assume a rather long inference time period called inference latency to be allowed, while having a trade-off between inference latency and accuracy. One of the main reasons for this phenomenon stems from the difficulty in determining proper a firing threshold for spiking neurons. The threshold determination procedure is called a threshold balancing technique in the CNN–SNN conversion approach. This paper proposes a CNN–SNN conversion method with a new threshold balancing technique that obtains converted SNN models with good accuracy even with low latency. The proposed method organizes the SNN models with soft-reset IF spiking neurons. The threshold balancing technique estimates the thresholds for spiking neurons based on the maximum input current in a layerwise and channelwise manner. The experiment results have shown that our converted SNN models attain even higher accuracy than the corresponding trained CNN model for the MNIST dataset with low latency. In addition, for the Fashion-MNIST and CIFAR-10 datasets, our converted SNNs have shown less conversion loss than other methods in low latencies. The proposed method can be beneficial in deploying efficient SNN models for recognition tasks on resource-limited systems because the inference latency is strongly associated with energy consumption.
A study on clinical spectrum of lichen sclerosus in a tertiary care Centre in North India

Introduction: Lichen sclerosus (LS) is a chronic dermatosis frequently located over labial, perineal, and perianal areas. The etiology is multifactorial and includes genetic, autoimmune, hormonal, and infectious aspects. Materials and Methods: A series of twenty genital LS patients was carried out to evaluate the signs, symptoms, complications, and affliction of quality of life. Results: Eighteen out of twenty patients were female between 30 and 73 years and showed smooth, glistening, and whitish plaques. The mean duration was 8.4 years. Itching and burning was the most common symptom (75%) corresponding to excoriation and fissuring of genitalia (75%). Malignancy was seen in two cases (10%). The mean Vulvar Quality of Life Index was 9.2, higher in younger patients. Discussion: LS is a disorder of older age group with female preponderance. It is a source of significant morbidity, and long-standing cases predispose to vulvar malignancy. Conclusion: To conclude, early diagnosis with proper counselling of the patient and his/her partner regarding various aspects of disease are essential for a wholesome approach.