Miracle-dz/UniFAR-FTUs huggingface dataset:
Nonlinear free vibration of thin functionally graded beams using the finite element method

A finite element model of large amplitude free vibrations of thin functionally graded beams with immovably supported ends is developed in this paper. The material properties of functionally graded beams are assumed to vary according to the power law distribution through the thickness direction. The finite element model is formulated in a variationally correct way based on Euler-Bernoulli beam theory and von Karman geometric nonlinearity. The linear exact displacement fields of the static case are used as the shape functions. The time response of each node is assumed to be a harmonic function, and the error residuals due to this assumption are minimized by employing the Galerkin method. Together this assumption and method transform the finite element equations to an eigenvalue equation that can be solved using a direct iterative method in tandem with the principle of energy conservation. The accuracy of the proposed method is demonstrated by comparing the frequencies and amplitudes with those of other methods presented in the literature. Finally, the relation between the frequencies of functionally graded beams and those of the homogeneous beams at various initial amplitudes is also examined.
Equatorial Convectively Coupled Waves in a Simple Multicloud Model

Abstract Linear stability results for the multicloud model recently developed by the authors on an equatorial beta plane are presented here. The linearized equations, about a realistic radiative–convective equilibrium (RCE) are projected in the meridional direction via a Galerkin truncation procedure based on the parabolic cylinder functions. In a suitable parameter regime, the multicloud model exhibits convectively coupled Kelvin, M = 0 eastward (Yanai), and M = 1 westward inertia–gravity waves, unstable at the synoptic scales in agreement with the outgoing longwave radiation (OLR) spectral peaks observed by Wheeler and Kiladis. The horizontal wave structure and vertical wavenumber of the unstable waves qualitatively match those of the rotating equatorial shallow water waves but with a reduced phase speed, as in the observations. More importantly, they exhibit the same self-similar front-to-rear vertical tilt in the zonal winds, temperature, and heating fields as observed by Kiladis and colleagues. Simil.
Anisotropic Resistivity Size Effect in Epitaxial Mo(001) and Mo(011) Layers

Mo(001) and Mo(011) layers with thickness d = 4–400 nm are sputter-deposited onto MgO(001) and α-Al2O3(112¯0) substrates and their resistivity is measured in situ and ex situ at room temperature and 77 K in order to quantify the resistivity size effect. Both Mo(001) and Mo(011) layers are epitaxial single crystals and exhibit a resistivity increase with decreasing d due to electron surface scattering that is well described by the classical Fuchs and Sondheimer model. Data fitting yields room temperature effective electron mean free paths λ* = 14.4 ± 0.3 and 11.7 ± 0.3 nm, respectively, indicating an anisotropy with a smaller resistivity size effect for the Mo(011) orientation. This is attributed to a smaller average Fermi velocity component perpendicular to (011) surfaces, causing less surface scattering and a suppressed resistivity size effect. First-principles electronic structure calculations in combination with Boltzmann transport simulations predict an orientation dependent transport with a more pronounced resistivity increase for Mo(001) than Mo(011). This is in agreement with the measurements, confirming the effect of the Fermi surface shape on the thin-film resistivity. The predicted anisotropy λ001*/λ011* = 1.57 is in reasonable agreement with 1.66 and 1.23 measured at 77 and 295 K. The overall results indicate that the resistivity size effect in Mo is relatively small, with a measured product of the bulk resistivity times the effective electron mean free path ρoλ* = (7.7 ± 0.3) and (6.2 ± 0.2) × 10−16 Ωm2 for Mo(001) and Mo(011) layers. The latter value is in excellent agreement with the first-principles-predicted ρoλ = 5.99 × 10−16 Ωm2 and is 10% and 40% smaller than the reported measured ρoλ for Cu and W, respectively, indicating the promise of Mo as an alternate conductor for narrow interconnects.
“It’s the Economy, Stupid!”, Is it not? The Relationship between Press Freedom and the Status of the Economy in Western Media Systems

ABSTRACT The existing literature presents several studies which show that the levels of press freedom can affect the state of the economy. What has not thus far been investigated is whether the economy can affect the levels of press freedom, the specific economic conditions that mainly affect it and the differences among various countries. This study attempts to analyze the impact of economic conditions on the degree of press freedom, in 18 countries of the western world based on a quantitative analysis for the period 2002–2019, and advance our understanding of this relationship. We find that the state of the economy within a country can affect the level of press freedom while the effects of economic conditions on the degree of press freedom seem to vary among different media systems of the western world.
Genome-wide identification, structural and evolutionary characteristics, and expression analysis of aquaporin gene family members in Mercenaria mercenaria

Aquaporins (AQPs) are highly-selective transmembrane water transporters that are involved in the adaptation to environmental challenges. However, the structure, function, and evolution of AQPs in bivalves remain largely unknown. In this study, AQP gene family members were identified in nine bivalve species, and their abundance rangs from 7 to 15. Nine AQPs (MmAQPs) were identified in the genome of hard clam (Mercenaria mercenaria), which is a euryhaline bivalve that has evolved sophisticated osmoregulatory mechanisms and salinity adaptation. Structurally, all MmAQPs contain 6 or 12 transmembrane α-helices, a major intrinsic protein (MIP) domain, and 2 asparagine-proline-alanine (NPA) motifs. MmAQPs were classified into three subfamilies based on phylogenetic analysis: AQP1-like, AQP3-like, and AQP8-like. No AQP11-like subfamily member was identified in the genome of hard clam. Tandem duplication resulted in a lineage-specific expansion in AQP8-like subfamily in hard clams. MmAQP8 genes showed different expression sensitivity to different environmental stressors. The gene expression patterns of three MmAQP8 were similar under heat, hypoxia, and air exposure stress, but differed greatly under salinity stress, indicating that tandem duplication events may accelerate the functional divergence of AQP8 genes in hard clams. AQP3-like members may have undergone gene loss during evolution, resulting in weakened glycerol and urea penetration in hard clams. Three orthologs of MmAQPs were detected in the genomes of Cyclina sinensis and Archivesica marissinica through synteny analyses. Tissue expression profiles showed that MmAQP genes were highly expressed in the foot and hepatopancreas. Under environmental stress, the expression levels of most of the MmAQP genes changed significantly to maintain metabolic homeostasis. Several MmAQP genes were downregulated to reduce water permeability under salinity and air exposure stress. Several MmAQP genes were significantly upregulated to promote the transmembrane transport of ammonia and reactive oxygen species and activate anti-apoptotic responses to resist stress. This study provides a comprehensive understanding of the AQP gene family in hard clams, and lays a foundation for further studies to explore the functions of AQPs in bivalves.
Efficient Synthesis of 1H-Benzo[4,5]imidazo[1,2-c][1,3]oxazin-1-one Derivatives Using Ag2CO3/TFA-Catalyzed 6-endo-dig Cyclization: Reaction Scope and Mechanistic Study

A small library of 1H-benzo[4,5]imidazo[1,2-c][1,3]oxazin-1-one derivatives was prepared in good to excellent yields, involving a Ag2CO3/TFA-catalyzed intramolecular oxacyclization of N-Boc-2-alkynylbenzimidazole substrates. In all experiments, the 6-endo-dig cyclization was exclusively achieved since the possible 5-exo-dig heterocycle was not observed, indicating the high regioselectivity of this process. The scope and limitations of the silver catalyzed 6-endo-dig cyclization of N-Boc-2-alkynylbenzimidazoles as substrates, bearing various substituents, were investigated. While ZnCl2 has shown limits for alkynes with an aromatic substituent, Ag2CO3/TFA demonstrated its effectiveness and compatibility regardless of the nature of the starting alkyne (aliphatic, aromatic or heteroaromatic), providing a practical regioselective access to structurally diverse 1H-benzo[4,5]imidazo[1,2-c][1,3]oxazin-1-ones in good yields. Moreover, the rationalization of oxacyclization selectivity in favor of 6-endo-dig over 5-exo-dig was explained by a complementary computational study.
PGT-SR: A Comprehensive Overview and a Requiem for the Interchromosomal Effect

Preimplantation genetic testing for structural rearrangements (PGT-SR) was one of the first applications of PGT, with initial cases being worked up in the Delhanty lab. It is the least well-known of the various forms of PGT but nonetheless provides effective treatment for many carrier couples. Structural chromosomal rearrangements (SRs) lead to infertility, repeated implantation failure, pregnancy loss, and congenitally affected children, despite the balanced parent carrier having no obvious phenotype. A high risk of generating chromosomally unbalanced gametes and embryos is the rationale for PGT-SR, aiming to select for those that are chromosomally normal, or at least balanced like the carrier parent. PGT-SR largely uses the same technology as PGT-A, i.e., initially FISH, superseded by array CGH, SNP arrays, Karyomapping, and, most recently, next-generation sequencing (NGS). Trophectoderm biopsy is now the most widely used sampling approach of all PGT variants, though there are prospects for non-invasive methods. In PGT-SR, the most significant limiting factor is the availability of normal or balanced embryo(s) for transfer. Factors directly affecting this are rearrangement type, chromosomes involved, and sex of the carrier parent. De novo aneuploidy, especially for older mothers, is a common limiting factor. PGT-SR studies provide a wealth of information, much of which can be useful to genetic counselors and the patients they treat. It is applicable in the fundamental study of basic chromosomal biology, in particular the purported existence of an interchromosomal effect (ICE). An ICE means essentially that the existence of one chromosomal defect (e.g., brought about by malsegregation of translocation chromosomes) can perpetuate the existence of others (e.g., de novo aneuploidy). Recent large cohort studies of PGT-SR patients seem, however, to have laid this notion to rest, at least for human embryonic development. Unless new evidence comes to light, this comprehensive review should serve as a requiem.
AppraisalCloudPCT: A Computational Model of Emotions for Socially Interactive Robots for Autistic Rehabilitation

Computational models of emotions can not only improve the effectiveness and efficiency of human-robot interaction but also coordinate a robot to adapt to its environment better. When designing computational models of emotions for socially interactive robots, especially for robots for people with special needs such as autistic children, one should take into account the social and communicative characteristics of such groups of people. This article presents a novel computational model of emotions called AppraisalCloudPCT that is suitable for socially interactive robots that can be adopted in autistic rehabilitation which, to the best of our knowledge, is the first computational model of emotions built for robots that can satisfy the needs of a special group of people such as autistic children. To begin with, some fundamental and notable computational models of emotions (e.g., OCC, Scherer's appraisal theory, PAD) that have deep and profound influence on building some significant models (e.g., PRESENCE, iGrace, xEmotion) for socially interactive robots are revisited. Then, a comparative assessment between our AppraisalCloudPCT and other five significant models for socially interactive robots is conducted. Great efforts have been made in building our proposed model to meet all of the six criteria for comparison, by adopting the appraisal theories on emotions, perceptual control theory on emotions, a component model view of appraisal models, and cloud robotics. Details of how to implement our model in a socially interactive robot we developed for autistic rehabilitation are also elaborated in this article. Future studies should examine how our model performs in different robots and also in more interactive scenarios.
Magnetic holes in the solar wind

An analysis is presented of high resolution interplanetary magnetic field measurements from the magnetometer on Explorer 43, which showed that low magnetic field intensities in the solar wind at 1 AU occur as distinct depressions or 'holes'. These magnetic holes are new kinetic-scale phenomena, having a characteristic dimension on the order of 20,000 km. They occurred at a rate of 1.5/day in the 18-day time span (March 18 to April 6, 1971) that was analyzed. Most of the magnetic holes are characterized by both a depression in the absolute value of the magnetic field, and a change in the magnetic field direction; some of these are possibly the result of magnetic merging. However, in other cases the magnetic field direction does not change; such holes are not due to magnetic merging, but might be a diamagnetic effect due to localized plasma inhomogeneities. (auth)
On nonholonomic mobile robots and optimal maneuvering

The authors consider the robot path planning problem in the presence of nonintegrable kinematic constraints, known as nonholonomic constraints. Such constraints are generally caused by one or several rolling contacts between rigid bodies and express that the relative velocity of two points in contact is zero. They make the dimension of the space of achievable velocities smaller than the dimension of the robot's configuration space. Using standard results in differential geometry (Frobenius integrability theorem) and nonlinear control theory, the authors first give a formal characterization of holonomy (and nonholonomy) for robot systems subject to linear differential constraints and state some related results about their controllability. They then apply these results to 'car-like' and 'trailer-like' robots. Finally, they present an implemented planner, which generates collision-free paths with a minimal number of maneuvers for car-like and trailer-like robots among obstacles. <<ETX>>
STUDY THE OPTICAL PROPERTIES OF THE VARIOUS DEPOSITION SOLUTIONS OF ZnO NANORODS GROWN ON GLASS SUBSTRATE USING CHEMICAL BATH DEPOSITION TECHNIQUE

In this study, two-step chemical bath deposition (CBD) technique has been employed for the fabrication of Zinc Oxide (ZnO) nanorods at low temperature. The ZnO nano-seed layer was deposited on the glass substrate using a radio frequency sputtering discharge technique. The impact of three zinc salts with Hexamethylenetetramine (HMTA) on the properties of ZnO nanorods have been investigated. The double beam UV visible (UV4100) spectrometer, micro-Raman scattering, and Field emission scanning electron microscopy (FESEM) were used to characterize and study the optical properties, energy band gap, defects, Raman spectra, phase orientation, quality of material, the interaction of phonons, transport properties, and the morphology of synthesized ZnO nanorods (NRs), respectively. The three zinc salts are Zinc Nitrate Hexahydrate, Zinc Acetate, and Zinc Chloride. The results found that the variation in zinc salts types with Hexamethylenetetramine as deposition solution is play a very important impact on the structures of fabricated ZnO nanorods that effected directly on the optical properties, energy band, material quality, and phase orientation of ZnO NRs. Also, from UV measurement the optical properties and energy band gap of produced ZnO nanorods are changed with changing the zinc salt as a precursor of deposition solution.
Modelling of natural convection flows with large temperature differences : a benchmark problem for low Mach number solvers. Part 1, Reference solutions

There are very few reference solutions in the literature on non-Boussinesq natural con- vection flows. We propose here a test case problem which extends the well-known De Vahl Davis differentially heated square cavity problem to the case of large temperature differences for which the Boussinesq approximation is no longer valid. The paper is split in two parts: in this first part, we pro- pose as yet unpublished reference solutions for cases characterized by a non-dimensional temperature difference of 0.6, Ra = 10 6 (constant property and variable property cases) and Ra = 10 7 (variable property case). These reference solutions were produced after a first international workshop organized by CEA and LIMSI in January 2000, in which the above authors volunteered to produce accurate numerical solutions from which the present reference solutions could be established.
Spin crossover, structural change, and metallization in NiAs-type FeO at high pressure

We report high-spin to low-spin crossover of iron in NiAs (B8)-type Fe${}_{0.96}$O (FeO hereafter) at high pressure by a combination of in-situ x-ray emission spectroscopy (XES) and x-ray diffraction (XRD) measurements. The XES spectra show a loss of spin in B8-type FeO approximately above 119 GPa at 300 K, consistent with the \ensuremath{\sim}2.5% volume reduction around 120 GPa. The high-temperature XRD study also demonstrates a similar volume decrease at 1560\char21{}1780 K under the same pressure condition. While the crystal structure of FeO remains to be B8 type across such volume reduction, the atomic arrangements of Fe and O change from inverse to normal NiAs form with considerable decrease in $c$/$a$ axial ratio. With recent electrical resistance measurements, these suggest that iron spin crossover, inverse-normal structural change, and insulator-metal transition occur concurrently in B8 FeO around 120 GPa.
Genesis Criteria for Diabatic Rossby Vortices: A Model Study

AbstractA suite of idealized mesoscale model simulations are conducted to examine the dynamic pathway to the genesis of short-scale, moist baroclinic disturbances. It is shown that in an initially subsaturated environment, two distinct stages of development are necessary before a preexisting surface-concentrated, warm-core vortex can begin to amplify. The first stage, termed environmental preconditioning, involves the moistening of the lower atmosphere via the transport of relatively high equivalent potential temperature air into the immediate environment of the translating vortex.The second stage results from continuous cloud diabatic processes and it involves the emergence of a low-level positive potential vorticity (PV) anomaly with some evidence of a further, more diffuse, negative PV anomaly at higher elevations. The PV structure is characteristic of a diabatic Rossby vortex (DRV). The disturbance does not begin to amplify until the magnitude and coherence of the low-level PV structure allows for the.
Uniform Accuracy of the Quasicontinuum Method

The accuracy of the quasicontinuum method is studied by reformulating the summation rules in terms of reconstruction schemes for the local atomic environment of the representative atoms. The necessary and sufficient condition for uniform first order accuracy and consequently the elimination of the “ghost force” is formulated in terms of the reconstruction schemes. The quasi-nonlocal approach is discussed as a special case of this condition. Examples of reconstruction schemes that satisfy this condition are presented. Transition between atom-based and element-based summation rules are studied.
PI3k Inhibitors in NHL and CLL: An Unfulfilled Promise

Abstract Phosphatidylinositol 3-kinases (PI3Ks) are a family of intracellular signal transducer enzymes that can attach a phosphate group to the 3’-hydroxyl of the inositol moiety of membrane-embedded phosphatidylinositol (PI). PI3Ks have been shown to play important roles in cell proliferation, growth, survival, motility, and metabolism. Nonetheless, the PI3K pathway has also shown to be overactivated in several tumors, particularly B-cell malignancies. In recent years, the PI3K signaling pathway has become the major focus of substantial drug discovery and development efforts. Selective (PI3K) inhibitors have been approved for the treatment of chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL), and indolent non-Hodgkin lymphomas (iNHL), such as follicular lymphoma and marginal-zone lymphoma. Four selective PI3K inhibitors have received accelerated FDA approvals for the treatment of patients with relapsed/refractory (R/R) CLL and/or iNHL based mainly on single-arm Phase II studies: Idelalisib (PI3K-δ inhibitor), copanlisib (dual PI3K-α and PI3K-δ inhibitor), duvelisib (dual PI3K-γ and PI3K-δ inhibitor), and umbralisib (dual PI3Kδ and CK1ε inhibitor). Conversely, recent interim results of randomized control trials (RCTs) involving some of these agents, showed a worrisome trend of decrease in overall survival (OS), and an increase in fatal and severe adverse effects, in comparison with patients in the control arms. Consequently, the class of PI3K inhibitors came under scrutiny, with an FDA expert panel voting on April 21, 2022, recommending that future FDA approvals of PI3K inhibitors be supported by randomized data, rather than single-arm data only, and further discontinuing the use of almost all the PI3K inhibitors in hematologic malignancies. As we believe further research is needed to help potentialize PI3K inhibitors by improving their safety profiles, this mini-review aims at revisiting the clinical successes, the failures, and the promising aspect of this class of drugs, while presenting possible ways that could benefit its successful development.