Miracle-dz/UniFAR-FTUs huggingface dataset:
Beneficial Effect of Cuban Policosanol on Blood Pressure and Serum Lipoproteins Accompanied with Lowered Glycated Hemoglobin and Enhanced High-Density Lipoprotein Functionalities in a Randomized, Placebo-Controlled, and Double-Blinded Trial with Healthy Japanese

This study evaluated the efficacy and safety of 20 mg of Cuban policosanol in blood pressure (BP) and lipid/lipoprotein parameters of healthy Japanese subjects via a placebo-controlled, randomized, and double-blinded human trial. After 12 weeks of consumption, the policosanol group showed significantly lower BP, glycated hemoglobin (HbA1c), and blood urea nitrogen (BUN) levels. The policosanol group also showed lower aspartate aminotransferase (AST), alanine aminotransferase (ALT), and γ-glutamyl transferase (γ-GTP) levels at week 12 than those at week 0: A decrease of up to 9% (p < 0.05), 17% (p < 0.05), and 15% (p < 0.05) was observed, respectively. The policosanol group showed significantly higher HDL-C level and HDL-C/TC (%), approximately 9.5% (p < 0.001) and 7.2% (p = 0.003), respectively, than the placebo group and a difference in the point of time and group interaction (p < 0.001). In lipoprotein analysis, the policosanol group showed a decrease in oxidation and glycation extent in VLDL and LDL with an improvement of particle shape and morphology after 12 weeks. HDL from the policosanol group showed in vitro stronger antioxidant and in vivo anti-inflammatory abilities. In conclusion, 12 weeks of Cuban policosanolconsumption in Japanese subjects showed significant improvement in blood pressure, lipid profiles, hepatic functions, and HbA1c with enhancement of HDL functionalities.
Tillage, crop establishment and residue retention methods for optimising productivity and profitability under rice–wheat system

ABSTRACT Conventional tillage and crop establishment methods for the rice–wheat (RW) system are input intensive (water, labour and energy). About 24.5 million tonnes of rice residues are burnt every year on farms in north-western India before sowing of wheat, causing air pollution and soil health degradation. Therefore, alternative tillage, crop establishment and residue management practices are needed for long-term sustainability of the RW system. A 4-year field study evaluated four tillage and crop establishment methods in rice (in main plots) and three tillage and rice residue management methods in wheat (in subplots) for their effects on yield, soil fertility, and profitability of the RW system. Average rice yields were similar under conventional puddled transplanted rice (PTR) and conventional till dry seeder rice (CTDSR). Both of these treatments produced significantly greater yields (10–16%) compared with zero till DSR (ZTDSR) and ZT machine transplanted rice in non-puddled soil, respectively, regardless of tillage and straw management methods in the previous wheat crop. Wheat yields in ZT wheat (ZTW) with 100% surface retention of rice residue (+R) were significantly greater than conventional till without residue retention after 2 years of experimentation, and accompanied by significant increases in macro-nutrient (potassium) availability in soil. The ZTW−R (no residue) treatment produced 15% lower wheat yield than ZTW+R. System yield was highest in CTDSR-ZTW+R, which was 5% higher than the conventional practice PTR-CTW−R, resulting in Rs 17 000 ha−1 greater net returns.
Pengaruh Gaya Kepemimpinan Dan Budaya Organisasi Terhadap Kepuasan Orang Tua Dalam Pembelajaran Anak Usia Dini

Penelitian ini bertujuan untuk mengungkap Gaya kepemimpinan (X1) dan Budaya organisasi (X2) terhadap kepuasan pembelajaran anak usia dini (Y). Penelitian ini menggunakan jenis penelitian kuantitatif dengan pendekatan survei. Penelitian ini dilakukan berdasarkan persepsi orang tua siswa terkait dengan variabel Gaya kepemimpinan (X1), variabel Budaya organisasi (X2) dan variabel kepuasan pembelajaran anak usia dini (Y). Populasi dalam penelitian ini adalah orang tua siswa kelompok B di TA/TK Al Azhar Syifa Budi dengan sampel penelitian orang tua siswa kelompok B yang berjumlah 54 orang. Dengan teknik sampel jenuh seluruhnya sebanyak 54 orang digunakan sebagai sampael penelitian. Pengambilan data menggunakan instrumen yang valid dan reliabel. Analisis data menggunakan regresi sederhana untuk menguji pengaruh (X1) terhadap (Y), Pengaruh X2 terhadap Y, dan analisis regresi ganda menguji X1 dan X2 secara simultan terhadap Y. Hipotesa penelitian a). diduga Gaya kepemimpinan berpengaruh positif terhadap kepuasan pembelajaran anak usia dini. ; b) Budaya organisasi berpengaruh positif terhadap kepuasan pembelajaran anak usia dini. ; c). Gaya kepemimpinan dan Budaya organisasi secara bersama-sama berpengaruh positif terhadap kepuasan pembelajaran anak usia dini.Kata Kunci: Gaya kepemimpinan, Budaya organisasi, kepuasan pembelajaran, Anak Usia Dini
The Hypolipidemic Characteristics of a Methanol Extract of Fermented Green Tea and Spore of Eurotium cristatum SXHBTBU1934 in Golden Hamsters

Fuzhuan brick tea (FBT), a distinctive Chinese dark tea with the predominant fungus of Eurotium cristatum, offered significant health benefits to Chinese people. In the current study, the in vivo bioactivities of E. cristatum (SXHBTBU1934) fermented green tea and spores of E. cristatum fermented on wheat were investigated, respectively. The methanol extract of fermented green tea and spore of E. cristatum both showed potent lipid-lowering activity in the blood of a high-fat diet induced hyperlipidemia model in golden hamsters and significantly reduced the accumulation of fat granules in the liver. These results indicated that the key active components were produced by E. cristatum. Chemical investigations suggested similar components in the two extracts and led to the identification of a new alkaloid, namely variecolorin P (1), along with four known structurally related compounds, (-)-neoechinulin A (2), neoechinulin D (3), variecolorin G (4), and echinulin (5). The structure of the new alkaloid was elucidated by HRESIMS, 1H, 13C, and 2D NMR analysis. The lipid-lowering activity of these compounds was evaluated using an oleic acid-induced HepG2 cell line model. Compound 1 significantly reduced the lipid accumulation in the HepG2 cell line with an IC50 value of 0.127 μM.
Feature Map Compression for Video Coding for Machines Based on Receptive Block Based Principal Component Analysis

This paper presents a method to effectively compress the intermediate layer feature map of a convolutional neural network for the potential structures of Video Coding for Machines, which is an emerging technology for future machine consumption applications. Notably, most extant studies compress a single feature map and hence cannot entirely consider both global and local information within the feature map. This limits performance maintenance during machine consumption tasks that analyze objects with various sizes in images/videos. To address this problem, a multiscale feature map compression method is proposed that consists of two major processes: receptive block based principal component analysis (RPCA) and uniform integer quantization. The RPCA derives the complete basis kernels of a feature map by selecting a set of major basis kernels that can represent a sufficient percentage of global or local information according to the variable-size receptive blocks of each feature map. After transforming each feature map using the set of major basis kernels, a uniform integer quantizer converts the 32-bit floating-point values of the set of major basis kernels, corresponding RPCA coefficients, and a mean vector to five-bit integer representation values. Experiment results reveal that the proposed method reduces the amount of feature maps by 99.30% with a loss of 8.30% in the average precision (AP) on the OpenImageV6 dataset and 0.77% in $AP_{M}$ and 0.47% in $AP_{L}$ on the MS COCO 2017 validation set while outperforming previous PCA-based feature map compression methods even at higher compression rates.
Efficacy and safety of Iguratimod as an add-on therapy for refractory lupus nephritis: A preliminary investigational study

Objectives IGU (IGU), a novel immunomodulatory agent for rheumatoid arthritis, has been shown to be effective and safe as monotherapy in a small population with refractory lupus nephritis (LN). The aim of this prospective study was to evaluate the efficacy and safety of IGU as an add-on therapy in patients with refractory LN in the context of clinical practice. Methods This is a single-arm observational study. We have enrolled LN patients since 2019 at Renji Hospital. All participants should have recurrent or refractory LN with at least one immunosuppressant (IS) and have a baseline urine protein/creatinine ratio (UPCR) >1.0. After enrollment, we added IGU (25 mg twice daily) to one of their previous immunosuppressants (IS) without increasing the dose of steroids. The primary outcome was the complete renal response (CRR) in the 6th month. UPCR decrease of over 50% was defined as partial response (PR). Extended follow-up was performed after the initial 6 months. Results We enrolled 26 eligible participants. 11/26 patients had chronic kidney disease (CKD) stage 2/3 at the baseline. The IS combined with IGU included mycophenolate mofetil, tacrolimus, and cyclosporin A. No IS change was allowed. 80.7% of patients had baseline steroids less than 0.5mg/kg daily and there was no steroids escalation during the IGU treatment. The CRR rate was 42.3% (11/26) at month 6. With a median follow-up of 52 weeks (range: 23-116 weeks), the CRR rate at the last visit was 50% (13/26) and 73.1% (19/26) of patients had UPCR decrease of over 50%. Six patients withdrew, three for no response and three for renal flare after initial CRR. One patient had an estimated glomerular filtration rate worsening of over 20% and was classified as renal flare. Three mild to moderate adverse events were recorded. Conclusions Our investigation merits further investigation in IGU as a potentially tolerable component of combination therapy for refractory LN.
Flowfield and Sound from a Blunt Trailing Edge with Varied Thickness

The flowfield and sound generated by turbulent flow passing over the trailing edge of an airfoil was studied experimentally. The airfoil geometries considered were thin, flat models that provided canonical, zero-pressure-gradient, turbulent boundary layers upstream of the trailing edge. The Reynolds number based on the chord was 2×106. A trailing edge with a symmetric, tapered, sharp edge was studied first. This allowed the use of a simple scattering theory to predict the radiated sound based on boundary-layer surface pressure. Second, a series of blunt, asymmetric, trailing-edge models were studied. The lower surface of the edge was flat, while the upper surface was rounded with a 45 deg trailing-edge angle. Three models were considered, which provided a variation in the ratio of model thickness to thickness of the approach boundary layer. Particle image velocimetry measurements were obtained to provide insight into the local flowfield dynamics that generated the sound. Acoustic measurements from the blu.
Myricetin attenuates hypoxic-ischemic brain damage in neonatal rats via NRF2 signaling pathway

Introduction: Hypoxic-ischemic encephalopathy (HIE) is a crucial cause of neonatal death and neurological sequelae, but currently there is no effective therapy drug for HIE. Both oxidative stress and apoptosis play critical roles in the pathological development of HIE. Myricetin, a naturally extracted flavonol compound, exerts remarkable effects against oxidative stress, apoptosis, and inflammation. However, the role and underlying molecular mechanism of myricetin on HIE remain unclear. Methods: In this study, we established the neonatal rats hypoxic-ischemic (HI) brain damage model in vivo and CoCl2 induced PC12 cell model in vitro to explore the neuroprotective effects of myricetin on HI injury, and illuminate the potential mechanism. Results: Our results showed that myricetin intervention could significantly reduce brain infarction volume, glia activation, apoptosis, and oxidative stress marker levels through activating NRF2 (Nuclear factor-E2-related factor 2) and increase the expressions of NRF2 downstream proteins NQO-1 and HO-1. In addition, the NRF2 inhibitor ML385 could significantly reverse the effects of myricetin. Conclusion: This study found that myricetin might alleviate oxidative stress and apoptosis through NRF2 signaling pathway to exert the protective role for HI injury, which suggested that myricetin might be a promising therapeutic agent for HIE.
STRUCTURE OF WITT RINGS, QUOTIENTS OF ABELIAN GROUP RINGS, AND ORDERINGS OF FIELDS

In particular, Theorems 5 and 6 yield the results of [5, §3] for Witt rings of formally real fields and Theorem 7 those of [5, §5] for Witt rings of nonreal fields. By studying subrings of the rings described in Theorems 5-7 and using the results of [2] for symmetric bilinear forms over a Dedekind ring
High-Pressure Crystal Structure Prediction Using Evolutionary Algorithm Simulation

We implemented a high-pressure crystal structure prediction using evolutionary algo-rithm method, one of successful method to deal with this kind of problems. This method employs three evolution operators to generate a new oﬀspring from its parents; heredity operator, permutation operator, and mutation operator. We run two simulation tests to this method and found results having a good agreement with experimental results. We also found some metastable structures produced by this method.
Recent Improvements in Fast Wave Heating in NSTX

Recent improvements in high-harmonic fast wave (HHFW) core heating in NSTX are attributed to using lithium conditioning, and other wall conditioning techniques, to move the onset density for perpendicular fast wave propagation further from the antenna. This has resulted in the first observation of HHFW core electron heating in deuterium plasma at a launched toroidal wavenumber, kφ = -3 m-1, NSTX record core electron temperatures of 5 keV in helium and deuterium discharges and, for the first time, significant HHFW core electron heating of deuterium neutral-beam-fuelled H-mode plasmas. Also, kφ = -8 m-1 heating of the plasma startup and plasma current ramp-up has resulted in significant core electron heating, even at central electron densities as low as ~ 4x1018 m-3.
Relativistic Jet Formation from Black Hole Magnetized Accretion Disks: Method, Tests, and Applications of a General RelativisticMagnetohydrodynamic Numerical Code

Relativistic jets are observed in both active galactic nuclei (AGNs) and ``microquasars" in our Galaxy. It is believed that these relativistic jets are ejected from the vicinity of black holes. To investigate the formation mechanism of these jets, we have developed a new general relativistic magnetohydrodynamic (GRMHD) code. We report on the basic methods and test calculations to check whether the code reproduces some analytical solutions, such as a standing shock and a Keplerian disk with a steady state infalling corona or with a corona in hydrostatic equilibrium. We then apply the code to the formation of relativistic MHD jets, investigating the dynamics of an accretion disk initially threaded by a uniform poloidal magnetic field in a nonrotating corona (either in a steady state infall or in hydrostatic equilibrium) around a nonrotating black hole. The numerical results show the following: as time goes on, the disk loses angular momentum as a result of magnetic braking and falls into the black hole. The infalling motion of the disk, which is faster than in the nonrelativistic case because of general relativistic effects below 3rS (rS is the Schwarzschild radius), is strongly decelerated around r = 2rS by centrifugal force to form a shock inside the disk. The magnetic field is tightly twisted by the differential rotation, and plasma in the shocked region of the disk is accelerated by the J × B force to form bipolar relativistic jets. In addition, and interior to, this magnetically driven jet, we also found a gas-pressure-driven jet ejected from the shocked region by the gas-pressure force. This two-layered jet structure is formed not only in the hydrostatic corona case but also in the steady state falling corona case.
Cannabidiol treatment improves metabolic profile and decreases hypothalamic inflammation caused by maternal obesity

Introduction The implications of maternal overnutrition on offspring metabolic and neuroimmune development are well-known. Increasing evidence now suggests that maternal obesity and poor dietary habits during pregnancy and lactation can increase the risk of central and peripheral metabolic dysregulation in the offspring, but the mechanisms are not sufficiently established. Furthermore, despite many studies addressing preventive measures targeted at the mother, very few propose practical approaches to treat the damages when they are already installed. Methods Here we investigated the potential of cannabidiol (CBD) treatment to attenuate the effects of maternal obesity induced by a cafeteria diet on hypothalamic inflammation and the peripheral metabolic profile of the offspring in Wistar rats. Results We have observed that maternal obesity induced a range of metabolic imbalances in the offspring in a sex-dependant manner, with higher deposition of visceral white adipose tissue, increased plasma fasting glucose and lipopolysaccharides (LPS) levels in both sexes, but the increase in serum cholesterol and triglycerides only occurred in females, while the increase in plasma insulin and the homeostatic model assessment index (HOMA-IR) was only observed in male offspring. We also found an overexpression of the pro-inflammatory cytokines tumor necrosis factor-alpha (TNFα), interleukin (IL) 6, and interleukin (IL) 1β in the hypothalamus, a trademark of neuroinflammation. Interestingly, the expression of GFAP, a marker for astrogliosis, was reduced in the offspring of obese mothers, indicating an adaptive mechanism to in utero neuroinflammation. Treatment with 50 mg/kg CBD oil by oral gavage was able to reduce white adipose tissue and revert insulin resistance in males, reduce plasma triglycerides in females, and attenuate plasma LPS levels and overexpression of TNFα and IL6 in the hypothalamus of both sexes. Discussion Together, these results indicate an intricate interplay between peripheral and central counterparts in both the pathogenicity of maternal obesity and the therapeutic effects of CBD. In this context, the impairment of internal hypothalamic circuitry caused by neuroinflammation runs in tandem with the disruptions of important metabolic processes, which can be attenuated by CBD treatment in both ends.
Lipid bilayers and interfaces

We developed a method to evaluate the mechanical properties of the monolayers in symmetric surfactant bilayers using self-consistent field theory. A specific boundary condition is used to impose the same curvature onto the two opposing monolayers at the surfactant chemical potential equal to that of the corresponding homogeneously curved bilayer. Typically the spontaneous monolayer curvature J 0 6= 0 and its value depends on the surfactant architecture. This is of importance for the thermodynamics and topology of lamellar surfactant phases. Furthermore, it may be relevant in processes involving biological membranes, e.g., the fusion and budding of vesicles and the incorporation of proteins in lipid bilayers.
Sim-to-Real Surgical Robot Learning and Autonomous Planning for Internal Tissue Points Manipulation Using Reinforcement Learning

Indirect simultaneous positioning (ISP), where internal tissue points are placed at desired locations indirectly through the manipulation of boundary points, is a type of subtask frequently performed in robotic surgeries. Although challenging due to complex tissue dynamics, automating the task can potentially reduce the workload of surgeons. This letter presents a sim-to-real framework for learning to automate the task without interacting with a real environment, and for planning preoperatively to find the grasping points that minimize local tissue deformation. A control policy is learned using deep reinforcement learning (DRL) in the FEM-based simulation environment and transferred to real-world situation. Grasping points are planned in the simulator by utilizing the trained policy using Bayesian optimization (BO). Inconsistent simulation performance is overcome by formulating the problem as a state augmented Markov decision process (MDP). Experimental results show that the learned policy places the internal tissue points accurately, and that the planned grasping points yield small tissue deformation among the trials. The proposed learning and planning scheme is able to automate internal tissue point manipulation in surgeries and has the potential to be generalized to complex surgical scenarios.
A simple method for inverting the azimuthal anisotropy of surface waves

We investigate the problem of retrieving anisotropy as a function of depth in the mantle, from the observed azimuthal variations of Love and Rayleigh wave velocities. Following the approach of Smith and Dahlen, this azimuthal dependence is expressed in terms of a Fourier series of the azimuth θ. For the most general case of anisotropy (provided it is small enough), some simple linear combinations of the elastic tensor coefficients are shown to describe the total effect of anisotropy (both polarization anisotropy and azimuthal anisotropy) on the propagation of surface Waves. For the terms that do not depend on the azimuth the combinations are related to the elastic coefficients of a transversely isotropic mantle. For the azimuthal terms the relevant combinations are explicited. It is found that the partial derivatives of the azimuthal terms with respect to these combinations are easy to compute for they are proportional to the partial derivatives of a transversely isotropic model in the case of a plane-layered model. In a first approximation the same property holds true for a spherical earth and we calculate from PREM all the partial derivatives needed for performing the inversion of the azimuthal anisotropy of surface waves in the period range 50–300 s. It is observed that very shallow anisotropy can be responsible for substantial azimuthal variations up to the longest periods. With this approach it is also easy to compute the azimuthal variations of surface wave velocities produced by any anisotropic model. When a Ci j elastic tensor is chosen for the upper mantle, azimuthal variations up to 2% are obtained for Rayleigh waves. The azimuthal variations of Love wave velocities are very small. The 2 θ term of the azimuthal variations of Rayleigh wave velocities is the dominant term. Its fast axis corresponds to the fast axis of P waves.
Providing a clearer insight into how sport-related concussion and physical pain impact mental health, cognition, and quality of life

Sport-related concussion (SRC) and physical pain are both associated with poor mental health, impaired cognition, and reduced quality of life. Despite SRC and physical pain often co-occurring, there is little research that investigates these two factors together, and therefore it is difficult to conclude which of these contributes to the negative outcomes associated with them. Therefore, the present study aimed to investigate the effect of SRC and physical pain on mental health, cognitive ability, and quality of life. Depression was measured using the Center for Epidemiological Studies Depression Scale, anxiety was assessed using the State-Trait Anxiety Inventory while the SF-12 recorded health-related quality of life. A trail making task (TMT) assessed cognitive flexibility of participants. Analysis of 83 participants (43 concussed) revealed that SRC led to reduced accuracy on TMT(A) and (B), whereas physical pain was responsible for poorer mental health and reduced quality of life. This study highlights the influence that SRC has on cognitive ability and the impact that physical pain has on mental health and quality of life. With this information, we are better placed to predict the negative consequences of SRC and physical pain and therefore tailor support accordingly.