Miracle-dz/UniFAR-FTUs huggingface dataset:
The Impact of Challenge and Hindrance Stressors on Thriving at Work Double Mediation Based on Affect and Motivation

Although the relationship between stressors and thriving at work has been established, the linkage between them is still in the early stages of theory development. This study proposed a two-path model, based on Lepine’s stressors-performance model, to analyze the effects of the stressors on the thriving at work. Two complementary mediating paths were proposed, i.e., affective strain (positive affect) and motivation (self-efficacy), which were explained using affective events theory and expectancy theory, respectively. Based on the empirical data from 233 employees, the results show that challenge stressors could enhance employees’ positive affect and self-efficacy, thus leading to thriving at work; on the contrary, hindrance stressors would result in negative influences. In addition, it is also found that the effect of affective path tend to be greater than that of motivation path, which could provide a practical guide for organizations to effectively apply stress management and to promote employees thriving at work.
Plasma and Magnetic Field Turbulence in the Earth’s Magnetosheath at Ion Scales

Crossing the Earth’s bow shock is known to crucially affect solar wind plasma including changes in turbulent cascade. The present review summarizes results of more than 15 years of experimental exploration into magnetosheath turbulence. Great contributions to understanding turbulence development inside the magnetosheath was made by means of recent multi-spacecraft missions. We introduce the main results provided by them together with first observations of the turbulent cascade based on direct plasma measurements by the Spektr-R spacecraft in the magnetosheath. Recent results on solar wind effects on turbulence in the magnetosheath are also discussed.
Elevated Circulating IL-10 Producing Breg, but Not Regulatory B Cell Levels, Restrain Antibody-Mediated Rejection After Kidney Transplantation

Background Antibody-mediated rejection (AMR) occupies a major position for chronic rejection after kidney transplantation. Regulatory B cell (Breg) has been reported to have an inhibitory immune function, which contributes to the resistance for AMR. Methods A nested case–control study for nine healthy donors, 25 stable (ST) patients, and 18 AMR patients was performed to determine the type of Breg in maintaining immune tolerance and preventing AMR. Results Compared to the ST group, circulating interleukin (IL)-10+ Bregs, but not Bregs, significantly decreased. The receiver operating characteristic (ROC) curve analysis revealed that rather than the circulating Bregs, decreased circulating IL-10+ Breg levels were positively associated with AMR. However, kidney B cell and IL-10 infiltration was significantly increased in the AMR group with high expression of C-X-C motif chemokine 13 (CXCL13). In addition, circulating IL-10+ Bregs, rather than Bregs, remained higher than those at pre-operation, during the 90-day post-operation in immune homeostasis. Conclusion The circulating IL-10+ Breg levels are more appropriate measures for assessing the resistance of AMR after kidney transplantation.
Detecting Resource Limitation in a Large Herbivore Population Is Enhanced With Measures of Nutritional Condition

Resource limitation at the population level is a function of forage quality and its abundance relative to its per capita availability, which in turn, determines nutritional condition of individuals. Effects of resource limitation on population dynamics in ungulates often occur through predictable and sequential changes in vital rates, which can enable assessments of how resource limitation influences population growth. We tested theoretical predictions of bottom-up (i.e., resource limitation) forcing on moose (Alces alces) through the lens of vital rates by quantifying the relative influence of intrinsic measures of nutritional condition and extrinsic measures of remotely sensed environmental data on demographic rates. We measured rates of pregnancy, parturition, juvenile, and adult survival for 82 adult females in a population where predators largely were absent. Life stage simulation analyses (LSAs) indicated that interannual fluctuations in adult survival contributed to most of the variability in λ. We then extended the LSA to estimate vital rates as a function of bottom-up covariates to evaluate their influence on λ. We detected weak signatures of effects from environmental covariates that were remotely sensed and spatially explicit to each seasonal range. Instead, nutritional condition strongly influenced rates of pregnancy, parturition, and overwinter survival of adults, clearly implicating resource limitation on λ. Our findings depart from the classic life-history paradigm of population dynamics in ungulates in that adult survival was highly variable and generated most of the variability in population growth rates. At the surface, lack of variation explained by environmental covariates may suggest weak evidence of resource limitation in the population, when nutritional condition actually underpinned most demographics. We suggest that variability in vital rates and effects of resource limitation may depend on context more than previously appreciated, and density dependence can obfuscate the relationships between remotely sensed data and demographic rates.
Work-Family Conflict and Primary and Secondary School Principals’ Work Engagement: A Moderated Mediation Model

With the development of positive psychology, work engagement has received widespread attention from researchers in the fields of positive organizational behavior and occupational health. Some studies have shown that work-family conflict has an important influence on individual behaviors and attitudes, but little research has studied the influence of work-family conflict on work engagement. The present study examined whether the relationship between work-family conflict and work engagement was mediated by job satisfaction, and whether the mediating role was moderated by affective commitment. We surveyed 358 Chinese primary and secondary school principals using the Work-Family Conflict Scale, Job Satisfaction Scale, Affective Commitment Scale, and Work Engagement Scale. The results revealed that there is a significant negative correlation between work-family conflict and primary and secondary school principals’ work engagement, and this relationship was partially mediated by job satisfaction. Moreover, affective commitment played a moderating role in the relationship between job satisfaction and work engagement. Specifically, the relationship between job satisfaction and work engagement was significant for primary and secondary school principals with high and low affective commitment. The current study contributes to a better understanding of the relationship between work-family conflict and work engagement.
Hydroclimate Variability Influenced Social Interaction in the Prehistoric American Southwest

When droughts and floods struck ancient agrarian societies, complex networks of exchange and interaction channeled resources into affected settlements and migrant flows away from them. Did these networks evolve in part to connect populations living in differing climate regimes? Here, I examine this relationship with a long-term archaeological case study in the pre-Hispanic North American Southwest, analyzing 4.3 million artifacts from a 250-year period at nearly 500 archaeological sites. I use these artifacts to estimate how the flow of social information changed over time, and to measure how the intensity of social interaction between sites varied as a function of distance and several regional drought patterns. Social interaction decayed with distance, but ties between sites in differing oceanic and continental climate regimes were often stronger than expected by distance alone. Accounting for these different regional drivers of local climate variability will be crucial for understanding the social impacts of droughts and floods in the past and present.
Adaptive Cardiac Metabolism Under Chronic Hypoxia: Mechanism and Clinical Implications

Chronic hypoxia is an essential component in many cardiac diseases. The heart consumes a substantial amount of energy and it is important to maintain the balance of energy supply and demand when oxygen is limited. Previous studies showed that the heart switches from fatty acid to glucose to maintain metabolic efficiency in the adaptation to chronic hypoxia. However, the underlying mechanism of this adaptive cardiac metabolism remains to be fully characterized. Moreover, how the altered cardiac metabolism affects the heart function in patients with chronic hypoxia has not been discussed in the current literature. In this review, we summarized new findings from animal and human studies to illustrate the mechanism underlying the adaptive cardiac metabolism under chronic hypoxia. Clinical focus is given to certain patients that are subject to the impact of chronic hypoxia, and potential treatment strategies that modulate cardiac metabolism and may improve the heart function in these patients are also summarized.
Reduced Performance Due to Adenoviral Gizzard Erosion in 16-Day-Old Commercial Broiler Chickens in Iran, Confirmed Experimentally

Adenoviral gizzard erosion (AGE) in broilers is an emerging infectious disease with negative impact on flock productivity. Despite of known primary etiological role of fowl adenovirus serotype 1 (FAdV-1) in AGE, there are a limited number of field reports worldwide, possibly because the disease is less noticeable and clinically difficult to assess. The present study documents an outbreak of AGE in 16-day-old broiler chickens on a farm in the north of Iran and the reproduction of the disease in an experimental setting. In the field, a sudden onset of mortality was noticed in affected broilers resulting in 6% total mortality and decreased weight gain leading to approximately 1-week delay to reach the target slaughter weight. Necropsy findings in dead broilers revealed black colored content in crop, proventriculus and gizzard together with severe gizzard erosions characterized by multiple black-brown areas of variable size in the koilin layer and mucosal inflammation. Microscopic examination revealed necrotizing ventriculitis marked with severe dissociation of koilin layer and degeneration of glandular epithelium with infiltration of mononuclear inflammatory cells. FAdV-1 was isolated from affected gizzards. Phylogenetic analysis of the hexon loop-1 (L1) sequence of the isolated virus showed 100% identity with pathogenic FAdV-1 strains previously reported from broiler chickens with AGE. Subsequently, an in vivo study infecting day-old commercial layer chickens with the field isolate demonstrated characteristic lesions and histopathological changes of AGE together with decreased weight gain in the infected birds. For the first time, the progress of a natural outbreak of AGE in Iran is described and experimental reproduction of the disease is demonstrated. The findings highlight the economic impact of the disease for regional poultry production due to mortality and impaired weight gain of the affected broilers.
Specificity and Plasticity of the Functional Ionome of Brassica napus and Triticum aestivum Subjected to Macronutrient Deprivation

The composition of the functional ionome was studied in Brassica napus and Triticum aestivum with respect to the response of 20 elements under macronutrient deprivation. Analysis of relative root contents showed that some nutrients, such as Fe, Ni, Cu, Na, V, and Co, were largely sequestered in roots. After 10 days of deprivation of each one of these 6 macronutrients, plant growth was similar to control plants, and this was probably the result of remobilization from roots (Mg and Ca) or old leaves (N, P, K, S). Some tissue concentrations and net nutrient uptakes into roots were either decreased or increased, revealing multiple interactions (93 in wheat, 66 in oilseed rape) that were common to both species (48) or were species specific. While some interactions have been previously described (increased uptake of Na under K deficiency; or increased uptake of Mo and Se under S deficiency), a number of new interactions were found and some key mechanisms underlying their action have been proposed from analysis of Arabidopsis mutants. For example, nitrate uptake seemed to be functionally linked to Na(influx, while the uptake of vanadium was probably mediated by sulfate transporters whose expression was stimulated during S deprivation.
The Influence of B Cell Depletion Therapy on Naturally Acquired Immunity to Streptococcus pneumoniae

The anti-CD20 antibody Rituximab to deplete CD20+ B cells is an effective treatment for rheumatoid arthritis and B cell malignancies, but is associated with an increased incidence of respiratory infections. Using mouse models we have investigated the consequences of B cell depletion on natural and acquired humoral immunity to Streptococcus pneumoniae. B cell depletion of naïve C57Bl/6 mice reduced natural IgM recognition of S. pneumoniae, but did not increase susceptibility to S. pneumoniae pneumonia. ELISA and flow cytometry assays demonstrated significantly reduced IgG and IgM recognition of S. pneumoniae in sera from mice treated with B cell depletion prior to S. pneumoniae nasopharyngeal colonization compared to untreated mice. Colonization induced antibody responses to protein rather than capsular antigen, and when measured using a protein array B cell depletion prior to colonization reduced serum levels of IgG to several protein antigens. However, B cell depleted S. pneumoniae colonized mice were still partially protected against both lung infection and septicemia when challenged with S. pneumoniae after reconstitution of their B cells. These data indicate that although B cell depletion markedly impairs antibody recognition of S. pneumoniae in colonized mice, some protective immunity is maintained, perhaps mediated by cellular immunity.
Roles of Non-coding RNAs in Central Nervous System Axon Regeneration

Axons in the central nervous system often fail to regenerate after injury due to the limited intrinsic regeneration ability of the central nervous system (CNS) and complex extracellular inhibitory factors. Therefore, it is of vital importance to have a better understanding of potential methods to promote the regeneration capability of injured nerves. Evidence has shown that non-coding RNAs play an essential role in nerve regeneration, especially long non-coding RNA (lncRNA), microRNA (miRNA), and circular RNA (circRNA). In this review, we profile their separate roles in axon regeneration after CNS injuries, such as spinal cord injury (SCI) and optic nerve injury. In addition, we also reveal the interactive networks among non-coding RNAs.
The Impact of Diabetes Mellitus on the Second Primary Malignancies in Colorectal Cancer Patients

Introduction All colorectal cancer (CRC) survivors have an increased risk of developing second primary malignancies (SPMs). The association between diabetes mellitus (DM) and the risk of cancer is well known. However, the role of DM and its therapy in the development of SPMs in CRC patients is not well described. Methods In this single-institutional retrospective analysis we identified 1,174 colorectal carcinoma patients, median follow-up 10.1 years, (median age 63 years, 724 men). All patients over 18 years with histologically confirmed CRC who were admitted in the period 1.1. 2003- 31.12. 2013 and followed-up till 31.12. 2018 at the Masaryk Memorial Cancer Institute (MMCI) were screened for eligibility. The exclusion criteria were CRC diagnosed at autopsy, lost to follow-up and high risk of development of SPMs due to hereditary cancer syndrome. Tumours are considered multiple primary malignancies if arising in different sites and/or are of a different histology or morphology group. Comparisons of the basic characteristics between the patients with SPM and the patients without SPM were performed as well as comparison of the occurrence of SPMs by the site of diagnosis between the DM and non-DM cohorts and survival analyses. Results A SPM was diagnosed in 234 (20%) patients, DM in 183 (15%) patients. DM was diagnosed in 22.6% of those with SPM vs. in 13.8% of those without SPM (p=0.001). The most common types of SPMs in DM patients were other CRC, kidney, lung, bladder and nonmelanoma skin cancer, but only carcinoma of the liver and bile duct tracts was significantly more common than in the group without DM. Although breast cancer was the second most common in the group with DM, its incidence was lower than in the group without DM, as well as prostate cancer. A significantly higher incidence of SPMs was found in older CRC patients (≥ 65 years) and in those with lower stage colon cancer and DM. No significant difference in DM treatment between those with and without a SPM was observed including analysis of type of insulin. Conclusion CRC patients with diabetes mellitus, especially those with older age, and early stages of colon cancer, should be screened for second primary malignancies more often than the standard population. Patients without DM have longer survival. According to the occurrence of the most common second malignancies, a clinical examination, blood count, and ultrasound of the abdomen is appropriate, together with standard breast and colorectal cancer screening, and lung cancer screening under certain conditions, and should be recommended in CRC survivors especially in patients with intercurrent DM, however the necessary frequency of screening remains unclear.
Thermal Analysis of Co-Utilization of Empty Fruit Bunch and Silantek Coal Under Inert Atmosphere Using Thermogravimetric Analyzer (TGA)

Agricultural residues have been traditionally used as energy resources for many years. In light of current environmental and fossil fuel supplies for energy applications, agricultural residues are regarded as sustainable supplies for energy production. However, the suitability to be renewable fuel and as a co-fuel in coal combustion facilities has to be investigated. A thermal analysis was conducted to investigate the effect of the blending and heating rate of the thermal behavior of Malaysian bituminous coal (Silantek), oil palm biomass (empty fruit bunch), and their blends using thermogravimetric analysis. The investigation was done in an inert atmosphere at the heating rate of 10, 20, and 40°C/min. Characteristics including proximate, ultimate, and calorific analyses were also examined. Six different mass ratios were selected from both samples to study the effect of blending of the two materials. The results showed that thermal degradation of empty fruit bunch (EFB) occurred in three stages while Silantek coal (SC) only involved two regions due to their different fuel properties. The blending of both SC/EFB did not follow their individual samples, which showed non-additive behavior suggesting that there is an interaction between coal and biomass. The outcome of this research provides insight on the behavior of Malaysian bituminous coal and oil palm biomass, which enhances knowledge for the future of energy generation.
HPLC Determination of Linear Alkylbenzenesulfonate (LAS) in Aquatic Environment. Seasonal Changes in LAS Concentration in Polluted Lake Water and Sediment

Abstract An analytical method for linear alkylbenzenesulfonate (LAS) using HPLC was studied. It was found that the peaks of different LAS isomers with alkyl chain lengths between 11 and 14 could be separated by gradient elution with aqueous NaClO4 solution and acetonitrile. The pretreatment of the LAS in the environmental samples was studied and an easy-to-use method involving solvent extraction with 4-methyl-2-pentanone was developed. By using these techniques the concentrations of the different LAS analogues in environmental samples could be measured respectively. The method was used to determine LAS in the aquatic environment; and the seasonal changes of these chemicals were clearly observed.
Comparative studies on physically adsorbed and chemically bound IgG to carboxylated latexes. II

Abstract The aim of the present work is to compare the behavior of physically (passively) adsorbed and of chemically (covalently) bound IgG to carboxylated latexes (CLs). In this work we have tried to determine the advantages and disadvantages of covalent coupling of antibodies to CLs against the passive adsorption procedure. Physically adsorbed IgG was measured by direct UV spectrophotometry at 280 nm. Even when the protein has the same charge sign as its sorbent, adsorption occurs spontaneously, and this suggests an adsorption caused by hydrophobic forces. IgG chemically bound using the carbodiimide method was both directly measured using the bicinchoninic acid reaction (BCA method) and indirectly calculated using UV spectrophotometry. The covalent coupling had an efficiency rate of more than 70%. The different electrophoretic behavior shown by the IgG covalently bound to the CL particles versus that of the IgG passively adsorbed on these particles is due to the presence of the carbodiimide used in those that are chemically bound. Mobility values were dealt with using the most recent theoretical approaches, given by Ohshima and Kondo, to obtain information about the protein layer. The chemical coupling provides a better immunological response of the IgG–CL complexes.
Timed versus untimed recognition of L2 collocations: Does estimated proficiency modulate congruency effects?

Abstract Congruency (the availability of a direct first language translation) and level of proficiency have been reported among the most important determinants of second language collocation processing. However, only very few studies looked at the interaction between the two determinants, and none of these directly compared untimed collocation recognition assessed through traditional tests to timed recognition evident in psycholinguistic tasks. The current study administered both types of form recognition measures to 228 female Saudi English as a foreign language learners in two separate experiments: a traditional multiple-choice test (Experiment 1) and a timed acceptability judgment task (Experiment 2). Experiment 2 also tested 37 native speakers of English as a baseline for comparison. Congruency, estimated proficiency (vocabulary test scores), and the interaction between the two were evaluated as predictors of untimed and timed recognition through mixed-effects modeling. Results showed that congruency and estimated proficiency had a clear effect on untimed and timed recognition. More interesting, the effect of proficiency was clearer on timed recognition with a gradual decrease in the first language effect as proficiency increased getting closer to nativelike collocation processing. Results have implications for second language collocation learning and testing.
Ionic Conductivity and Magnesium Vacancy Mobility in Magnesium Oxide

The dc conductivity and ionic transference number of MgO single crystals doped with Al, Fe, and Sc were measured as a function of temperature (1200° to 1600°C) and oxygen pressure (10−1 to 10−13 MPa). Magnesium oxide is a mixed conductor with its ionic component directly proportional to the trivalent solute concentration. The activation energy for ionic conduction equals 202 kj/mol and is independent of the specific trivalent solute used. This behavior results from a defect structure for a single trivalent solute for which the charge balance condition is 2[VMg'] =[IMg], where [VMg”] is the Mg vacancy concentration and [IMg] the trivalent solute concentration. At lower temperatures and high Sc concentrations, effects attributed to Sc ionvacancy association are observed. Ionic conduction results from Mg vacancy motion with a diffusion coefficient of VMg' given by Deduced values of the Mg-ion diffusion coefficient lead to the conclusion that the scatter in the published DMg data largely results from differences in impurity content.