Miracle-dz/UniFAR-FTUs huggingface dataset:
CYP1B1 variants have low contribution to Pakistani patients with Primary Open Angle Glaucoma Page

Background Glaucoma is a group of complex neurodegenerative ophthalmological disorders and is the second common of cause of irreversible blindness around the globe. Primary open-angle glaucoma (POAG) is the commonest type of all glaucoma and is characterized by elevated intraocular pressure (IOP) leading to optic nerve damage and visual field defects. Inherited mutations in CYP1B1 are a rare cause of POAG. Objective This study was conducted to screen Pakistani population with POAG for CYP1B1 variants. Methods Detailed family history was recorded from all participating families. The disease was confirmed through ophthalmological examinations. Blood samples were collected for genomic DNA extraction. CYP1B1 exons were directly sequenced in one affected individual from each family. Results CYP1B1 sequencing revealed a novel heterozygous missense variant, c.649G>A (p.Asp217Asn). All affected individuals having the variant had characteristic glaucomatous changes with mean disease onset at 35 years. The unaffected individuals in the family had no signs of POAG. The prevalence of CYP1B1 associated POAG in study cohort is 4% (1/25). In silico predictions showed that p.Asp217Asn, substitution affects the structure and function of the protein. Conclusion The study suggests that CYP1B1 mutations are considered to have have less contribution in pathogenesis of POAG in Pakistani population studied. Identification of novel dominantly inherited variant shows allelic heterogeneity and may help in early diagnosis for effective management of the disease through genetic counseling.
Occlusal vertical dimension: Effect on esthetic norms at smile

Background and Objectives: The restorative and esthetic needs for the complete mouth rehabilitation patient frequently require an increase in occlusal vertical dimension (OVD), in whom there would be tooth loss or attrition in existing teeth, decreased OVD, or opposing teeth supraeruption. The effect of increasing OVD for restorative purpose and esthetic norms while smiling is not well understood; hence, the purpose of this study is to evaluate the effect of those norms at smile. Methods: Eighty patients (40 males and 40 females) were selected from the student population of AME's Dental College, Raichur, between the age groups 21 and 30 years, and occlusal registrations of 2, 4, 6, and 8 mm in thickness for each individual were fabricated from the articulated casts. Posed smile images at OVD +0, +2, +4, +6, and +8 were taken with a digital single lens reflex (DSLR) camera and evaluated using AutoCAD software. Results: In this study, it was found that with an increase in OVD, the interlabial gap height, incisal edge to lower lip distance, and display zone area were increased statistically significantly (P < 0.05) in both male and female patients, whereas the smile index was decreased significantly (P < 0.05). No significant changes were observed in the intercommissural width and incisal edge to the upper lip distance in both male and female patients. Conclusion: There is obvious effect of aesthetic norms such as the vertical distance between the incisal edge to upper lip, vertical distance between incisal edge–lower lips, interlabialgap height, intercommissural width, internal display zone area, and smile index in both male and female patients. The obtained values can serve as guide for esthetic rehabilitation of patients.
Evaluation of the complex lower leg (CLL) for its use in anti-vehicular mine testing applications

The Complex Lower Leg (CLL), originally developed to assess antipersonnel(AP) mine injuries, was identified as a suitable surrogate to develop an injury assessment methodology for foot/ankle injuries sustained by occupants exposed to anti-vehicular (AV) blast landmines. The objective of this work was to evaluate the CLL performance, with the best available techniques, for its use in a new application: AV mine testing. The approach was to use the standard Hybrid III instrumented lower leg to set the input conditions to which the CLL was submitted. The first part of the work consisted in 'low' severity testing. Owen et al (2001) and Funk et al (2002b) studies on post mortem human surrogates (PMHS) were recreated in order to compare CLL and PHMS responses. The CLL, submitted to non-injurious (based on Owen, 2001) and injurious (based on Funk, 2002b) conditions, showed realistic results. The second part of the study was to test the CLL under 'high' severity loading conditions representative to that of AV blast mine conditions. The results of this second testing suggest that the CLL might require some modifications to improve its biofidelity in terms of foot/ankle injury prediction for these specific loading conditions. Finally, the work also includes the results of the tibia axial force measured with a load cell installed on the CLL for the first time. In conclusion, the Complex Lower Leg showed satisfying results within the scope of the current work and thus, is believed to be a suitable tool to evaluate foot/ankle sustained by anti-vehicular blast landmine. For the covering abstract see ITRD E134311.
Short‐ and Long‐Term Outcome Results from a Multisite Evaluation of the G.R.E.A.T. Program

Youth gangs continue to garner substantial attention from the media, public, and academic researchers as result, in large part, of the violence contributed to gang members. Several prevention, intervention, and suppression programs have been introduced to address problems associated with youth games, but today, relatively few have been deemed as promising, let alone as effective. KEYWORDS: Juvenile justice; Juvenile delinquency Language: en
Data Warehousing: The Route to Mass Customisation

From the Publisher: In this book Sean Kelly takes a step beyond the technological architectural aspects of information technology (IT) to reveal it as a driver of corporate strategy formulation. The data warehouse is illustrated as the essential technological vehicle required to slice and dice the market into the micro segments that will enable mass production industrial organisations to transform themselves into mass-customisation customer-focused businesses. Sean Kelly provides a coherent conceptual framework of the cognitive process. He charts a course for these organisations embarking on the corporate data warehouse journey, allowing them to see the totality of data in the enterprise constructed into integrated patterns and pictures which can add dramatic value to decision making. Corporate directors, information systems professionals and business users of information systems alike cannot afford to ignore the message in this book.
Exosome Mediated Purinergic Mechanisms in Breast Cancer

Breast cancer is the most diagnosed cancer and the second leading cause of cancer-related deaths in women. Majority of these deaths are due to metastasis, proving that there is a great demand to understanding the mechanisms underlying metastasis. One factor released by breast cancer cells called nucleoside diphosphate kinase (NDPK) has been shown to stimulate endothelial cell proliferation, migration, and tumor-meditated angiogenesis. Extracellular NDPK generates ATP in the vicinity of the breast cancer cells to activate purinergic P2Y1 receptors on adjacent endothelial cells. The P2Y1 transactivates the VEGFR-2 on the endothelial cells to promote angiogenesis. Although NDPK was detected in conditioned media of breast cancer cells and in the serum of mice bearing tumors; the appearance of extracellular NDPK in the local tumor microenvironment has remained a mystery. We proposed that NDPK travels out of the cancer cells by small extracellular vesicles called exosomes. Exosomes were purified from breast cancer cells and characterized by transmission electron microscopy, flow cytometry, western blot analysis. These signaling vectors were also examined for angiogenic response by a tubulogenesis assay with inhibitors of NDPK and P2Y1. Further development for NDPK inhibitors were tested with a drug screen utilizing the NDPK transphosphorylation assay to identify novel small molecules that could inhibit NDPK. The in vivo role of NDPK was examined with two orthotopic mouse models while tracking the growth and development of the primary tumors and metastases. Both models were also treated with inhibitors of NDPK and P2Y1. NDPK was associated with exosomes from breast
Frequency domain analysis of Hopf bifurcations in electric power networks

An approach is discussed for studying certain types of parametric instabilities in electric power networks that are associated with a Hopf bifurcation. The method is based on a frequency-domain version of the Hopf bifurcation theorem due to A. Mees and L. Chua (1979) and is suitable for the detailed study of large-scale systems. The practical importance of establishing the type of Hopf bifurcation, i.e., subcritical or supercritical, is emphasized. Systems which operate near a subcritical Hopf bifurcation point are clearly vulnerable to disturbances. <<ETX>>
Reading and Internet Use Activities of Undergraduate Students of the University of Calabar, Calabar, Nigeria

Students’ learning in the digital age depends on both adequate search for learning materials through Internet use activities, and adequate reading and study of the materials. Nevertheless, a lack of balance between the amount of time and effort devoted by students to reading and Internet use activities could affect negatively their learning achievement. This study explored the patterns of and relationships between reading and Internet use activities of undergraduate students of the University of Calabar, Nigeria. A descriptive survey design and the random sampling technique were used to administer 200 copies of a designed questionnaire to the undergraduate students of the university who used the university library during April 2009. Of these, 133 usable copies were returned, for a response rate of about 65%. Results showed that the students appreciated the importance of reading to their academic achievement, and were also highly aware of the importance of the Internet for the timely acquisition of new information and knowledge. Although 61.5% of the students preferred Internet browsing to reading of printed books, journals and newspapers, only 36.8% of them agreed that Internet use encouraged laziness in reading. The study recommended adequate library and Internet access facilities and programmes in Nigerian universities to promote balanced reading and Internet use activities among undergraduates. University librarians should also explore means of meeting students’ rising demands for electronic resources, and provide effective publicity and current awareness of the variety of existing and new information resources and services available to students in the university libraries Keywords: Reading, Internet use, learning, universities, students, Nigeria
Manejo da fertirrigação e salinidade do solo no crescimento da cultura da beterraba

With the increase in world population and scarcity of natural resources, efficient use of fertilizers becomes necessary for intensive agriculture. The experiment was conducted in a greenhouse at the Department of Agricultural Engineering, UNESP in Botucatu-SP. The treatments were derived from the combination of the soil salinity (E.C: 1.0, 3.0, 6.0, 9.0 and 12.0 dS m-1), Fertigation management (M1 =traditional and M2 = with control of the ionic concentration of the soil solution) and beet cultivars (C1= Early Wonder and C2 = Itapua) in a 5x2x2 factorial design with four replications in a randomized block design. Throughout the cultivation, the following variables were evaluated: height, stem diameter, length and diameter of plant roots. The height of the plant presented differently according to the Fertigation management and sensitive to levels of electrical conductivity in the soil. The diameter of the roots showed reductions of 3.55 and 2.48 mm for C1 and C2, respectively, every unit increase in electrical conductivity (EC) to M1. Based on the functional relationship of the best adjustment between the diameter of the roots and electrical conductivity in M2 gave an estimated maximum diameter of 90.78 mm to 94.67 mm for C1 and C2.
Cardiac Function Evaluation with Cine MRI of the Heart

This unit describes how to determine hemodynamic parameters of cardiac function such as ejection fraction (EF), end diastolic volume (EDV), end systolic volume (ESV), stroke volume (SV), and cardiac mass, based on experience using a Siemens 1.5 T Sonata scanner. Briefly, cine loops are acquired over several heartbeats, synchronized with the heart cycle by gating of the encoding steps with the patients electrocardiogram (ECG). Recently, it has become feasible to acquire cine loops in real time, although the temporal resolution is not optimal. Options discussed in this unit include breath hold versus free breathing, prospective triggering versus retrospective gating, and volumetric data sets versus biplanar approaches. Patient parameters such as heart rate or rhythm, degree of functional impairment, the presence of valvular disease, and the need to assess for jets from shunts or valve dysfunction are also treated.
Tightness testing of rotary ferromagnetic fluid seal working in water environment

Purpose – The purpose of this publication is to determine the influence of selected factors on the durability and the tightness of ferrofluid seals working in water environments. Ferromagnetic fluid (FF) seals are one of the most common applications of magnetic fluid. New applications can be developed by extending the capabilities of these seals in fluid environments, especially in water. Design/methodology/approach – Tests were performed using ferrofluids with differing physical properties like density, dynamic viscosity and saturation magnetization. Working conditions, such as water pressure and peripheral speed, were taken into account. Findings – A mathematical description which allows the selection of an appropriate ferrofluid and the determination of the operating parameters of an FF seal was developed. Originality/value – This study concerns the influence of peripheral speed, water pressure and magnetic fluid properties on seal tightness.
A Novel Methodology for the Sustainability Impact Assessment of New Technologies

The introduction of new technologies can have profound impact on society and nature. Therefore, a need exists for a method that can provide a balanced assessment of new tech-nologies that takes into account all different impacts. Within the EU-funded PROSUITE pro-ject, the aim is to develop a methodology for the sustainability assessment of existing and emerging technologies. Here, existing approaches of sustainability assessment are re-viewed. All of them have their merits, but none of them is applicable in a generic way to all aspects of sustainability for a technology. Using concepts developed initially for environ-mental life cycle assessment, we propose an approach consisting of the following major impact categories: 1) impact on human health; 2) impact on social well-being; 3) impact on prosperity; 4) impact on natural environment; 5) impact on exhaustible resources. All pri-mary impacts can be grouped under these categories. For several of these categories still quite some analysis of mechanisms in the cause-effect chain is necessary and there will be substantial remaining uncertainties for the others. For a complete assessment, the five major impact categories need to be integrated. Several approaches are available for this purpose, such as multicriteria analysis with or without weighted aggregation.
Engage: The Complete Guide for Brands and Businesses to Build, Cultivate, and Measure Success in the New Web

Praise for Engage! "It's no longer an era of business as usual. Executives and entrepreneurs must embrace new media in order to not only compete for the future, but for mind share, market share, and, ultimately, relevance. This book helps you engage. Without it, you're competing for second place. " Mark Cuban, owner, Dallas Mavericks; investor; entrepreneur; and Chairman, HDNet "Affinity is personal and emotional. Without personifying the company and what it symbolizes, it's difficult for customers to connect with your brand. The concepts from this book can help your brand engage in a way that inspires communities to extend your message, promise, and reach. " Tony Hsieh, CEO, Zappos.com "The power of the top-down, A-list influencer is winding down. Now brands must engage on a direct-to-many basis. Social media makes this possible, and Solis makes this happen. Read his book or be left in the dust. " Guy Kawasaki, cofounder, Alltop "Social media is changing everything about the way people relate socially, in commerce, and in politics. Engage! gets you up to date regarding current trends and technology, and shows you how to build a serious social media strategy. It's the real deal. " Craig Newmark, founder, Craigslist.com "Before Solis, I was cluelessly competing in the attention economy of the twenty-first century. Solis's Engage! provides me with the intellectual capital to build relevancy amidst our cacophonous culture. This book is worth its weight in attentionthe digital gold of the twenty-first century. " Andrew Keen, author of the international hit Cult of the Amateur: How Today's Internet Is Killing Our Culture
Battery Usage and Thermal Performance of the Toyota Prius and Honda Insight for Various Chassis Dynamometer Test Procedures: Preprint

This study describes the results from the National Renewable Energy Laboratory's (NREL) chassis dynamometer testing of a 2000 model year Honda Insight and 2001 model year Toyota Prius. The tests were conducted for the purpose of evaluating the battery thermal performance, assessing the impact of air conditioning on fuel economy and emissions, and providing information for NREL's Advanced Vehicle Simulator (ADVISOR).
Ground-based Simulation of Upset Recovery in DESDEMONA: Aspects of Motion Cueing and Motion Perception

Unsuccessful recovery from unusual flight attitudes, or airplane upset, is considered an important factor in civil aviation accidents. It is generally recognized that there is a clear need for enhanced training of recovery procedures from unusual flight attitudes, i.e. situations where an aircraft unintentionally exceeds the parameters of the normal flight envelope. Exercising these conditions in the real world is unsafe, expensive and, if performed in smaller aircraft, not representative of the situation in commercial aircraft. Ground-based simulation of these extreme conditions is an interesting alternative for pilot instruction. However, at present, hexapod-based flight simulators used for pilot training are not certified for this purpose. Desdemona, a novel simulation facility, offers an extended motion envelope with enhanced motion capabilities which may prove adequate to simulate upset recovery events. The six degrees-of-freedom motion system features a gimbaled gondola which allows for unlimited rotation about three axes. In addition, the gondola can move up and down along a 2m long heave axis, and horizontally along an 8m long linear track. This track can be rotated on a planetary axis so as to produce a sustained linear acceleration up to 3G. The cockpit contains a projection system for out-the-window imagery, and can be reconfigured into different cockpit layouts. Desdemona has become operational in January 2008. This paper discusses the preliminary concepts for the simulation of upset recovery conditions based on the unique Desdemona motion features. This paper also introduces the motion envelope of upset conditions in support of pilot training.
Adaptive Control of Systems with Actuator and Sensor Nonlinearities

From the Publisher: An in-depth examination of intelligent approaches to increasing the accuracy of a variety of system components. Utilizing a unified, adaptive, inverse approach, the book offers electrical, mechanical, chemical, aeronautical and computer engineers methods for controlling many of the "hard" nonlinearities of frequently-employed control systems such as dead-zone, backlash and hysteresis. Discusses such nonlinearities at both the input and output points of a linear part and within both continuous time designs and discrete time designs.
Intra-Sectoral Structural Change and Aggregate Productivity Development. A Robust Stochastic Nonparametric Frontier Function Approach

This paper investigates the sources of total factor productivity growth in the German manu- facturing sector, 1981-1998. Decomposition formulae for aggregate productivity growth are used to identify the effects of structural change and entry-exit on aggregate productivity growth. Documented is a substantial rise of productivity growth after the German reunifica- tion. The bulk of this rise can be attributed to structural change and entry-exit. Two methodo- logical refinements are implemented, the first is the application of a robust stochastic non- parametric approach to frontier function analysis and the second is the calculation of boot- strap confidence intervals for the components of the productivity decompositions.
The role of the international criminal court in the implementation of the international humanitarian law: An applied study

This study seeks to clarify the importance of the International Criminal Court as a criminal mechanism in the application of international humanitarian law, and its effectiveness in limiting violations of this law by punishing the perpetrators of these violations as a permanent court, as well as its role in laying the foundations for international criminal justice. It has become necessary to clarify the importance of the Court and its effective role in the application of international humanitarian law, due to the presence of massive and brutal violations of human rights during armed conflicts as well as under the belligerent occupation. Previous legal studies dealt with the issue of the implementation of international humanitarian law, but it is accepted that they focused on the historical aspect of the emergence of international humanitarian law, and they focused on the theoretical aspect of the issue of mechanisms for implementing international humanitarian law more than the practical aspect and therefore did not adequately address the criminal mechanism represented in The establishment of the International Criminal Court and this is the basis on which our study is based. The previous studies lacked the application that enriches any study in this field. This is what we emphasized in our study and given the importance of the topic of the role of the International Criminal Court in the implementation of international humanitarian law and also considering the recentness of some mechanisms for the implementation of international humanitarian law, the studies that dealt with this topic remain insufficient, and many aspects of the study on this topic are still an area for research and study One of these aspects that have not been adequately researched and specifically the criminal mechanism for the implementation of international humanitarian law represented in the International Criminal Court, and this study comes to enrich the practical aspect of the implementation of international humanitarian law.