Miracle-dz/UniFAR-FTUs huggingface dataset:
Exploiting Illusory Grid Lines for Object-Location Memory Performance in Urban Topographic Maps

In order to be successful in spatial orientation tasks, people need to recall locations and configurations of spatial objects from their memory. This understanding of geographic space often arises from experience with cartographic media representing topographic and topological information by graphic symbols. Learning spatial information from graphic media is influenced by different perception-based grouping effects distorting the accuracy of spatial object-positions and their relations. Such geometric inaccuracies can be softened by adding a grid layer, which regionalizes the map and can be used as an additional orientation pattern. This grid layer usually consists of solid lines and overlays semantic information. The present paper reports the results of two empirical studies on object-location memory (OLM) performance. In these studies, the amount of visual detail of the grid layer was reduced. By positioning the grid layer below specific urban topographic objects (study 1), the grid pattern was graphically interrupted. These interrupted grid lines were completed by cognitive completion mechanisms (illusory grid lines) described in the Gestalt principles of closure and continuation. The second experiment examined the maximum grid line gap that is closed by cognitive line completion and keeps an advantage for OLM (study 2).
LATE TREMADOCIAN RADIOLARIAN FAUNAS AND BIOSTRATIGRAPHY OF THE COW HEAD GROUP, WESTERN NEWFOUNDLAND, CANADA

Late Tremadocian radiolarian faunas were first recovered from the Cow Head Group, Newfoundland, Canada. Three faunal assemblages were recognized, one from Martin Point and two from Western Brook Pond in Gros Morne National Park. These radiolarian faunas include six families, 11 genera, and 26 species. In these faunas, six genera (Archeoproventocitum, Cowheadia, Neopalaeospiculum, Protospongentactinia, Protoproventocitum and Westernbrookia) and 17 species (Archeoproventocitum nudiformum, A. retiformum, Aspiculum densum, A. jamesi, A. multistratum, A. gigantium, Cowheadia duplextesta, Neopalaeospiculum densum, N. laxum, N. transformum, Pararcheoentactinia stilla, Protospongentactinia spongiosa, Protoproventocium nazarovii, P. aitchisoni, Westernbrookia cancella, W. diversa, and W. ovata) are new. Late Tremadocian faunas are characterized by the appearance of proventocitiids and diversification of aspiculumids and reduction of protoentactiniids and echidniniids that had flourished in the early Tremadocian faunas. An examination of the biostratigraphic range of co-occurring conodonts indicates that the radiolarian faunas described here belong to the late Tremadocian, from the Lower Diversity Interval through the M. dianae Zone to the lower P. proteus Zone. With the recovery of conodonts of the R. manitouensis Zone from other localities in the study area, the correlation among Martin Point, Western Brook Pond, Broom Point, and St. Paul`s Inlet strata has became more precise. Also, the middle and late Tremadocian Cow Head Group can be subdivided into the R. manitouensis Zone, the Low Diversity Interval, and the M. dianae Zone of North America. The lower P. proteus Zone of the latest Tremadocian for northern Europe is recognized in the Western Brook Pond South section.
Molecular epidemiological characteristics of Mycobacterium leprae in highly endemic areas of China during the COVID-19 epidemic

Objectives The present study analyzed the impact of the COVID-19 pandemic on the prevalence and incidence of new leprosy cases, as well as the diversity, distribution, and temporal transmission of Mycobacterium leprae strains at the county level in leprae-endemic provinces in Southwest China. Methods A total of 219 new leprosy cases during two periods, 2018–2019 and 2020–2021, were compared. We genetically characterized 83 clinical isolates of M. leprae in Guizhou using variable number tandem repeats (VNTRs) and single nucleotide polymorphisms (SNPs). The obtained genetic profiles and cluster consequences of M. leprae were compared between the two periods. Results There was an 18.97% decrease in the number of counties and districts reporting cases. Considering the initial months (January–March) of virus emergence, the number of new cases in 2021 increased by 167% compared to 2020. The number of patients with a delay of >12 months before COVID-19 (63.56%) was significantly higher than that during COVID-19 (48.51%). Eighty-one clinical isolates (97.60%) were positive for all 17 VNTR types, whereas two (2.40%) clinical isolates were positive for 16 VNTR types. The (GTA)9, (TA)18, (TTC)21 and (TA)10 loci showed higher polymorphism than the other loci. The VNTR profile of these clinical isolates generated five clusters, among which the counties where the patients were located were adjacent or relatively close to each other. SNP typing revealed that all clinical isolates possessed the single SNP3K. Conclusion COVID-19 may have a negative/imbalanced impact on the prevention and control measures of leprosy, which could be a considerable fact for official health departments. Isolates formed clusters among counties in Guizhou, indicating that the transmission chain remained during the epidemic and was less influenced by COVID-19 preventative policies.
Objective mapping of the seasonal variability of ΔPCO2in the North Atlantic ocean

Through objective analysis, seasonal maps of ΔPCO 2 (the difference between surface ocean and atmospheric PCO 2 ) were derived for the North Atlantic (10 S to 80 N) from available PCO 2 measurements taken between 1978 and 1993. For lack of data, however, maps do not cover the entire North Atlantic during all four seasons. Changes in ΔPCO 2 due to the rise in anthropogenic CO 2 are neglected. For each of the four quarterly ΔPCO 2 maps, the objective analysis approach also provides an associated map of its uncertainty. As expected, results agree reasonably well where data exist, and uncertainties are relatively large where substantial interpolation or extrapolation was necessary.
Analysis of Traffic and Navigation Conditions on Nowy Świat Canal

: The issue of safety and free navigation near the Vistula Lagoon for many years was a dispute between Poland and Russia. The most debatable and conflicting topic, especially in Poland, was building a new connection between the Gulf of Gdansk and the Vistula Lagoon. This paper describes the functional processes and mechanisms of the new lock installed at the harbour Nowy Ś wiat and the results of quantitative analysis of traffic changes resulting from that addition (from the beginning of their operations through January 2023). The next part of the work focuses on safety navigation analysis for typical vessels which operate on this newly built waterway. Underkeel clearance analysis and the channel ʹ s minimum safety width were carried out, assuming the most common types of ship. The research results provide the foundation for further potential analysis of the Nowy Ś wiat Canal transport possibilities.
Indoor and Outdoor Spectroradiometer Intercomparison for Spectral Irradiance Measurement

This report details the global spectral irradiance intercomparison using spectroradiometers that was organized by the National Renewable Energy Laboratory's Solar Radiation Research Laboratory. The intercomparison was performed both indoors and outdoors on September 17, 2013. Five laboratories participated in the intercomparison using 10 spectroradiometers, and a coordinated measurement setup and a common platform were employed to compare spectral irradiances under both indoor and outdoor conditions. The intercomparison aimed to understand the performance of the different spectroradiometers and to share knowledge in making spectral irradiance measurements. This intercomparison was the first of its kind in the United States.
Journal of Reproduction and Development

Kisspeptin, identified as a natural ligand of GPR54 in 2001, is now considered as a master regulator of puberty and subsequent reproductive functions in mammals. Our previous studies using Kiss1 knockout (KO) rats clearly demonstrated the indispensable role of kisspeptin in gonadotropin-releasing hormone (GnRH)/gonadotropin secretion. In addition, behavioral analyses of Kiss1 KO rats revealed an organizational effect of kisspeptin on neural circuits controlling sexual behaviors. Our studies using transgenic mice carrying a region-specific Kiss1 enhancer-driven reporter gene provided a clue as to the mechanism by which estrogen regulates Kiss1 expression in hypothalamic kisspeptin neurons. Analyses of Kiss1 expression and gonadotropin secretion during the pubertal transition shed light on the mechanism triggering GnRH/gonadotropin secretion at the onset of puberty in rats. Here, we summarize data obtained from the aforementioned studies and revisit the physiological roles of kisspeptin in the mechanism underlying reproductive functions in mammals.
Interictal epileptic network hubs as a biomarker for automatic localization of the epileptogenic zone: a connectivity and machine learning based analysis of stereo-EEG.

Objective: The study was aimed at developing an automatic system, based on complex network analysis and machine learning, to identify interictal network-based biomarkers in patients with drug-resistant focal epilepsy and no visible anatomical lesions candidate for surgery, able to support the localization of the Epileptogenic Zone (EZ) and to further disclose properties of the interictal epileptogenic network. Methods: 3 min of interictal SEEG signals, recorded in 18 patients with drug-resistant epilepsy, different EZ localization, negative MRI, were analysed. Patients were divided into seizure-free (SF) and non-seizure free (NSF) groups, according to their post-surgical outcome. After a first step of effective connectivity estimation, hubs were defined through the combination of nine graph theory-based indices of centrality. The values of centrality indices related to these hubs were used as input of an ensemble subspace discriminant classifier. Results: The proposed procedure was able to automatically localise the EZ with 98% sensitivity and 59% specificity for SF patients. Moreover, our results showed a clear difference between SF and NSF patients, mainly in terms of false positive rate (i.e., the percentage of NEZ leads classified as EZ), which resulted significantly higher in NSF patients. Lastly, the centrality indexes confirmed a different role of the Propagation Zone in NSF and SF groups. Significance: Results pointed out that network centrality plays a key role in interictal epileptogenic network, even in case of the absence of anatomical alterations and SEEG epileptic abnormalities, and that the combination of connectivity, graph theory, and machine learning analysis can efficiently support interictal EZ localization. These findings also suggest that poorer post-surgical prognosis can be associated with larger connectivity alteration, with wider hubs, and with a different involvement of the PZ, thus making this approach a promising biomarker for surgical outcome.
Processed food intake assortativity in the personal networks of East European older adults

Coalescing evidence shows that food habits circulate through social relationships. However, seniors' social networks and unhealthy dietary choices remain underexplored, particularly within rural Eastern Europe's unique socioeconomic and cultural contexts. We investigate how social networks affect the consumption of processed foods high in salt among community-dwelling older adults (64 years of age and older) from a Romanian rural community. We use an observational cross-sectional quantitative approach (a personal network research design) to collect self-reported information about the study participants (egos; n = 83), their social contacts (alters), and the relationships among them (ego-alter and alter-alter ties). We fit multi-level, mixed-effects models, clustering alters by their egos, and show that older adults eating processed food high in salt are more likely to be connected to alters with similar eating habits (assortativity). This result is of particular relevance when considering the nutritional health of older adults, as it implies that interventions targeting this demographic should extend beyond the individual to encompass their social environment. Despite the cross-sectional approach limitations, our work may enrich the understanding of dietary patterns among rural Eastern European seniors and provide an empirical foundation for designing targeted interventions that can mitigate health risks associated with high-salt diets in older populations.
Superspreading of SARS-CoV-2: a systematic review and meta-analysis of event attack rates and individual transmission patterns

SARS-CoV-2 superspreading occurs when transmission is highly efficient and/or an individual infects many others, contributing to rapid spread. To better quantify heterogeneity in SARS-CoV-2 transmission, particularly superspreading, we performed a systematic review of transmission events with data on secondary attack rates or contact tracing of individual index cases published before September 2021, prior to emergence of variants of concern and widespread vaccination. We reviewed 592 distinct events and 9,883 index cases from 491 papers. Meta-analysis of secondary attack rates identified substantial heterogeneity across 12 event types/settings, with the highest transmission (25-35%) in co-living situations including households, nursing homes, and other congregate housing. Among index cases, 67% produced zero secondary cases and only 3% (287) infected >5 secondary cases ("superspreaders"). The highest percentage of superspreaders was among symptomatic individuals, individuals aged 49-64 years, and individuals with over 100 total contacts. However, only 55% of index cases reported age, sex, symptoms, real-time PCR cycle threshold values, or total contacts. Despite the limitations, our review highlighted that SARS-CoV-2 superspreading is more likely in settings with prolonged close contact and among symptomatic adults with many contacts. Enhanced reporting on transmission events and contact tracing could help explain heterogeneity and facilitate control efforts.
Atypia of Undetermined Significance and ThyroSeq v3 Positive Call Rates as Quality Control Metrics for Cytology Laboratory Performance

Background: The Bethesda system (TBS) for reporting thyroid cytopathology recommends an atypia of undetermined significance (AUS) rate of 10%. Recent data suggest that this category might be overused when the rate of cases with molecular positive results is low. As a quality metric, we calculated the AUS and positive call rates for our cytology lab and each cytopathologist. Methods: A retrospective analysis of all thyroid cytology cases in a 4.5-year period was performed. Cases were stratified by TBS category, and molecular testing results were collected for indeterminate categories. The AUS rate was calculated for each cytopathologist (CP) and the laboratory. The molecular positive call rate (PCR) was calculated with and without the addition of currently negative to the positive results obtained from the ThyroSeq report. Results: 7,535 cases were classified as non-diagnostic 7.6%, benign 69%, AUS 17.5%, follicular neoplasm / suspicious for follicular neoplasm 1.4%, suspicious for malignancy 0.7 %, and malignant 3.8%. The AUS rate for each cytopathologist ranged from 9.9-36.8%. The overall PCR for the cytology laboratory was 24% (range 13-35.6% per CP). When including cases with currently negative results, the PCR increased to 35.5% for the cytology laboratory (range 13-42.6% per CP). Comparison analysis indicates a combination of overcalling benign cases and, less frequently, under calling of higher TBS category cases. Conclusions: The AUS rate in the context of PCR is a useful metric to assess cytology laboratory and cytopathologists' performance. Continuous feedback on this metric could help improve the overall quality of reporting thyroid cytology.
Genetic diversity of HPV35 in Chad and the Central African Republic, two landlocked countries of Central Africa: A cross-sectional study

Human Papillomavirus (HPV)-35 accounts for up 10% of cervical cancers in Sub-Saharan Africa. We herein assessed the genetic diversity of HPV35 in HIV-negative women from Chad (identified as #CHAD) and HIV-infected men having sex with men (MSM) in the Central African Republic (CAR), identified as #CAR. Ten HPV35 DNA from self-collected genital secretions (n = 5) and anal margin samples (n = 5) obtained from women and MSM, respectively, were sequenced using the ABI PRISM® BigDye Sequencing technology. All but one HPV35 strains belonged to the A2 sublineage, and only #CAR5 belonged to A1. HPV35 from #CAR had higher L1 variability compared to #CHAD (mean number of mutations: 16 versus 6). L1 of #CAR5 showed a significant variability (2.29%), suggesting a possible intra-type divergence from HPV35H. Three (BC, DE, and EF) out of the 5 capsid loops domains remained totally conserved, while FG- and HI- loops of #CAR exhibited amino acid variations. #CAR5 also showed the highest LCR variability with a 16bp insertion at binding sites of the YY1. HPV35 from #CHAD exhibited the highest variability in E2 gene (P<0.05). E6 and E7 oncoproteins remained well conserved. There is a relative maintenance of a well conserved HPV35 A2 sublineage within heterosexual women in Chad and MSM with HIV in the Central African Republic.
Expressive suppression moderates the relationship between PTSD from COVID-19 and somatization and validation of the Arabic version of Patient Health Questionnaire-15 (PHQ-15)

Background Lebanese adults have been crippled for years by several crises, including the lately COVID-19 pandemic. These massive civilian traumas have increased the risk of post-traumatic stress disorder (PTSD) in this population. Extensive literature pointed to the association between PTSD and somatization; however, the nature of this relationship remains unknown. We sought to contribute further to work in this area by testing the moderating role of emotion regulation in the relationship between COVID-19- related PTSD and somatization. As a secondary objective, we aimed to examine the psychometric properties of an Arabic translation of the somatization measure Patient Health Questionnaire-15 (PHQ-15) in terms of factorial validity and internal consistency before its use in the present study. Methods This cross-sectional study was conducted between September and October 2021. A total of 403 Lebanese adults residing in Lebanon were recruited. Eligible participants received an online link to the survey. The Patient Health Questionnaire-15 was used to assess somatization, PTSD Checklist–Civilian Version for PTSD and Emotion Regulation Questionnaire for emotion regulation. Results The results of the exploratory factor analysis (EFA) revealed a three-factor solution explaining 48.79% of the common variance. Confirmatory Factor Analysis results of the three-factor model obtained in the EFA indicated a good fit with a significant CFI of 0.98, TLI 0.98 and a GFI of . 97, a RMSEA of . 04 [90% CI . 01, . 06]. Higher PTSD symptoms were associated with somatization. In addition, we found that one specific ER component, i.e. expressive suppression, significantly moderated the relationship between PTSD from the COVID pandemic and somatization. In particular, the interaction PTSD from the COVID-19 pandemic by expressive suppression was significantly associated with somatization; at low, medium and high levels of expressive suppression, higher PTSD from the COVID-19 pandemic was significantly associated with higher somatization scores. As for our secondary objective, findings revealed that the Arabic version of the PHQ-15 exhibited good psychometric properties. In particular, the scale yielded a three-factor structure, and good internal consistency (Cronbach’s alpha = 0.87). Conclusion The moderating role of expressive suppression on the link between PTSD and somatization presents a novel finding in the field of trauma. Additionally, making a psychometrically sound Arabic version of the PHQ-15 available is a valuable addition to the literature.
Monitoring of taurine dietary supplementation effect on parameters of Duroc boar ejaculate in summer season

The aim of this experiment was to find out whether the taurine supplementation in daily ration had an effect on quantity or quality of Duroc boar ejaculate. The experiment duration was from June to August, when it could assumed the possible occurrence of heat stress. For the study was chosen 12 Duroc boars of approximately the same age and condition. The control group of 6 Duroc boars was fed only by basic diet and the experimental group of 6 Duroc boars was fed by the same basic diet with supplementation of 15 g taurine/boar/day. Ejaculate was collected once a week by hand glowed technique. From ejaculate parameters were monitored volume of ejaculate, sperm concentration, total amount of sperm, morphologically abnormal sperm, taurine concentration and GSH/GSSH concentration. From microscopic analysis, results were statistically significant in motility in June and July (P<0.05). In biochemical results, a significant difference (P<0.05) has been found between the experimental groups in the concentrations of taurine as well as GSH/GSSG in ejaculate which indicates the effect of heat stress on boars during the experimental period.
Syphilis: Is it Back with a Bang?

Background: Syphilis was brought under control with the advent of penicillin. However, in recent times, a rise in the incidence of syphilis has been reported by Centers for Disease Control and Prevention (CDC). Aim: To study the clinical and epidemiological profile of patients with syphilis attending sexually transmitted infection (STI) clinic at tertiary care center. Materials and Methods: Observational, cross-sectional analysis of sociodemographic, clinical, and investigational data of all syphilis patients visiting STI clinic from August 2019 to July 2021 was done and analyzed. Results: Out of 1330 STI patients that attended the clinic, 15.04% (n = 200) were diagnosed with syphilis, among them 72% (n = 144) were males, and 28% (n = 56) were females, with male-to-female ratio of 2.5:1. Of these 24.5% (n = 49) had primary, 44.5% (n = 89) had secondary, 30.5% (n = 61) had latent, and 0.50% (n = 1) had congenital syphilis. Among secondary syphilis patients, rash was the most common presentation seen in 43 patients, followed by condyloma lata in 30, palmoplantar syphilis in 17, oral mucous patch in 3, and iridocyclitis in 3 patients. Human immunodeficiency virus (HIV) was positive in 16.5% (n = 33). Herpes genitalis was the most common coinfection among 25 patients who were diagnosed with mixed venereal disease. RPR titer was positive in all 200 patients, with 1:16 titer being most common. Conclusion: India is experiencing a new trend in the prevalence of syphilis, mainly due to the changes in risk behavior, misconceptions, and social stigma associated with STIs, improved laboratory diagnosis, and increased public awareness. Particularly secondary and latent stages have shown a rising trend over the past few years. Awareness about safe sexual practices and contraception is very important to control the current resurgence.