Miracle-dz/UniFAR-FTUs huggingface dataset:
Relationship Between Tumor Mutational Burden and Maximum Standardized Uptake Value in PET (Positron Emission Tomography) Scan in Cancer Patients

Purpose: Deriving links between imaging and genomic markers is an evolving field. 18F-FDG PET/CT (18F-fluorodeoxyglucose Positron Emission Tomography- Computed Tomography) is commonly used for cancer imaging, with maximum standardized uptake value (SUVmax) as the main quantitative parameter. Tumor mutational burden (TMB), the quantitative variable obtained using next-generation sequencing on a tissue biopsy sample, is a putative immunotherapy response predictor. We report the relationship between TMB and SUVmax, linking these two important parameters. Methods: In this pilot study, we analyzed 1923 patients with diverse cancers and available TMB values. Overall, 273 patients met our eligibility criteria in that they had no systemic treatment prior to imaging/biopsy, and also had 18F-FDG PET/CT within six months prior to the tissue biopsy, to ensure acceptable temporal correlation between imaging and genomic evaluation. Results: We found a linear correlation between TMB and SUVmax (p<0.001). In the multivariate analysis, only TMB independently correlated with SUVmax whereas age, gender and tumor histology did not. Conclusion: Our observations link SUVmax in readily available, routinely used, and non-invasive 18F-FDG PET/CT imaging to the TMB, which requires a tissue biopsy and time to process. Since higher TMB has been implicated as a prognostic biomarker for better outcomes after immunotherapy, further investigation will be needed to determine if SUVmax can stratify patient response to immunotherapy.
Flexible Interoperable Transceiver (FIT) Program Test Range I: Radio Propagation Measurements at 440, 1360 and 1920 MHz Edwards Air Force Base, CA

Radiowave propagation measurements at Edwards Air Force Base, CA are described. These measurements were made as part of the Flexible Interoperable Transceiver (FIT) Program. The objective of the measurements is to define communication link requirements at 440, 1360, and 1920 MHz. Simultaneous wideband measurements at three frequencies were made using fixed transmitters and a mobile fitted with a multi-channel receiver. The system measured the radio channel impulse response. Data outputs include delay spread and basic transmission loss. These parameters are compared at the three measurement frequencies to determine additional propagation impairments military systems will suffer due to frequency translation from 440 MHz to 1360 MHz and 1920 MHz.
Assessment of waste streams in electric-discharge machining for environmental impact analysis

Abstract Since the turn of the century, many manufacturing processes have been systematically and scientifically analysed, with new ones being developed at the same time. This was done with the aim of achieving, through a high measure of innovation, a maximum efficiency in association with current economic manufacturing conditions. There has recently been growing awareness of the need to recognize a balanced approach to market objectives with green requirements. This paper presents a methodology for analysing the environmental impact of electric-discharge machining (EDM). The analytical model of EDM integrates the wear characteristics of the tool and workpiece, and the dielectric fluid flows. The multiple waste streams generated are compared by examining factors such as toxicity and flammability. A case study has been included as an illustrative example. This model may serve as a framework for decision making in process planning and selection of operating parameters.
Effect of varying axial load under fixed boundary condition on admittance signatures of electromechanical impedance technique

In recent years, researchers in the field of structural health monitoring have been rigorously striving to replace the conventional nondestructive evaluation techniques with the smart material–based structural health monitoring techniques. These techniques possess distinct advantages over the conventional techniques, such as capable of providing autonomous, real-time, reliable, and cost-efficient monitoring. For instance, the electromechanical impedance technique employing smart piezo-impedance transducer (lead zirconate titanate) is known for its sensitivity in detecting damage. The admittance signatures of the electromechanical impedance technique for structural health monitoring are susceptible to variation in the static load applied on the host structure, which should not be ignored. This article presents a series of experimental, analytical, and numerical studies conducted to investigate the effect of varying axial load in the presence of fixed boundary condition on the admittance signatures. Theoretically, the extensional vibration is not affected by any static axial load acting in the same direction. However, it is useful in identifying the effect of stiffening caused by the boundary condition upon increase in the axial force, which contributes to the discrepancy between the experiments and the analytical models. This study suggests that the effect of boundary condition is substantial, which should be carefully considered in real-life application of the electromechanical impedance technique for structural health monitoring.
A lateral active suspension for conventional railway bogies

The present paper describes an active centring system for railway vehicles. The proposed solution is based on lateral pneumatic actuators placed between bogie and car body connected to the vertical secondary suspension air springs. The objective of the developed centring system is twofold: the improvement of the curving behaviour of the train and the decrease of the lateral acceleration perceived by the passenger in curve negotiation thanks to the reduction of the ‘souplesse’ coefficient. The system is described in detail in the paper. Results from simulations are included considering a bidimensional model of the vehicle, and a detailed model of the air spring and control valves. The performance in curve negotiation of a vehicle equipped with this system and a conventional one is compared. Specifically, lateral displacements of the secondary suspension, roll angle and lateral accelerations are analysed. The results show noticeable performance improvements in the vehicle curving behaviour. The proposed centring system can be implemented in a conventional bogie without special design requirements; and due to the low air consumption, additional pressurised reservoirs are not required.
Parametric studies on the lateral restraints of pile caps in soil

The general behaviours of pile caps with vertical rectangular faces embedded in soil mass idealised as a semi-infinite elastic continuum under lateral shears and on-plan torsions are discussed in this paper. Approaches based on the elastic continuum theory with consideration of the soil pressure limited to the passive pressure values have been formulated for the estimation of lateral displacements and on-plan rotations of the pile cap. Based on the findings, parametric studies are then conducted with the production of tables for users to estimate the lateral translational and torsional resistances of pile caps and subsequently, their displacements and rotations under lateral shears and/or on-plan torsions. These tables, though not exactly reflecting the true elasto-plastic behaviour, give conservative results which are also fairly accurate as compared with that yielded by the elasto-plastic theory. The tables can therefore serve as a quick check for users without going into more sophisticated analyses such as the tedious finite element analysis by computer software. As a demonstration of the use of the tables, the method for determination of the combined actions of the pile cap and the pile group under lateral loads is also included, with the illustration of a worked example. Finally, the applicability and limitations of the approach in real cases including underground obstructions and non-homogeneity of soil properties are discussed.
A review of Singapore contractors' attitudes to environmental sustainability

Noting the Singapore government and its construction industry's efforts and progress in addressing environmental issues, this article reviews Singapore general contractors' current attitudes to environmental sustainability. On the basis of interview data and firms' archival records, the results show that the majority of the responding large- and medium-sized contractors positively embrace the idea of sustainability. The identified drivers of change support that the government and clients continue to play their important roles in leading the construction firms to improve their environmental management performance. A binary logistic regression model was also developed by relating the contractors' attitudes to (i) firm size and (ii) type of ownership. The results show that the contractors' attitudes were found to be significantly affected by firm size and type of ownership, with the large non-family-owned construction firms being most likely to show positive attitudes to environmental sustainability.
Technological changes in the innovation system towards 4G mobile service

Evolution of mobile communications has started from the development of first generation (1G) towards the upcoming fourth generation (4G) technology. In the technological shifts from one generation to another, changes have taken place and have generated implications to the actors in the innovation system. This paper presents analyses of technological changes of 1G/2G to third generation (3G) with an aim to build technology roadmap towards 4G. The research highlights the upcoming 4G profile based on quantitative analyses of bibliometric data and the trend model of 3G technologies. The findings show that the technological changes of mobile evolution have been characterised by the dominant persistence of principal technological agenda, i.e. wireless communications, mobile computing and data communications. In the evolutionary path towards 4G, there is an escalation of research related to quality of service and technologies to support advanced service infrastructure which indicates a shift from technical- to service-driven perspective. Finally, our work supports an association with experts' earlier prediction that 4G would be structured by heterogeneous networks, which requires interworking mechanism among different technological platform.
A benchmark problem for structural health monitoring

Concluding RemarksA task group consisting of a dozen or so active members has defined a benchmark for structural health monitoring consisting of simulated-data cases and experimental cases. The models and data are available for the research community to download at the web site of the task group at wusceel.cive. wustl.edu/asce.shm/.
Evaluation of ergonomics in a virtual manufacturing process

This paper presents a study of the evaluation of ergonomics using virtual tools in a pre-production phase when verifying the manual assembly of the XC90 car model at the Volvo Car Corporation. The case study focused especially on the verification of visual demands in assembly work due to its complexity. The virtual development process was mapped in observations of the use of virtual tools and interviews with actors involved in the verification. Results show that computer manikins are viable tools in verifying ergonomics early in a development process and that they help to detect many problems prior to physical pre-series. There are, however, substantial improvement potentials, both in the software itself and, even more, in the process of using virtual tools. The study identified several factors that can increase the reliability of the results of computer manikin simulations (e.g. participative ergonomics and documentation issues). The special focus on visual demands shows the need of basic knowledge about human behaviour for making valid simulations. This case study stresses the need for knowledge about simulations in both analysis and interpretations in order to achieve maximum output from a virtual manufacturing process.
The effect of geometrical parameters on the energy absorption characteristics of thin-walled structures under axial impact loading

In this study, the crush behaviour of thin-walled straight and conical shell structures was systematically determined for various absorber designs and investigated comparatively under axial impact loading. The main parameters in the design of these structures are cross-section geometry, wall thickness and semi-apical angle. Several cross sections have been studied: circular, square and hexagonal. In the finite element simulations, these designs were fixed at one end and impacted by a rigid wall from the other with specified mass and velocity giving the required impact energy according to the European regulation ECE R29 by using explicit finite element code LS-Dyna. After crash simulations, energy absorption characteristics and crush forces were obtained for each crush element having different cross sections, wall thicknesses and semi-apical angles. Peak crush force, mean crush force, crush force efficiency and specific energy absorption (SEA) were calculated for a deformation length of 100 mm. In all cases it was found that tubes were crushed progressively. The results of the simulations showed that the square cross-sectioned energy absorber has the lowest crush force efficiency among three cross-section geometries. The crush force efficiency was found to be the highest for the circular absorber which has a semi-apical angle of 12.5° and a wall thickness of 2 mm. Finally, the peak crush forces were lowered by creating blanks and corrugations.
Improving Zinc Finger Nucleases - Strategies for Increasing Gene Editing Activities and Evaluating Off-Target Effects

Zinc finger nucleases (ZFNs) induce double-strand DNA breaks at specific recognition sites. ZFNs can dramatically increase the efficiency of incorporating desired insertions, deletions, or substitutions in living cells. These tools have revolutionized the field of genome engineering in several model organisms and cell types including zebrafish, rats, and human pluripotent stem cells. There have been numerous advances in ZFN engineering and characterization strategies, some of which are detailed in this work. The central theme of this dissertation is improving the activity and specificity of engineered zinc finger nucleases with the ultimate goal of increasing the safety and efficacy of these tools for human therapy. As a first step, I undertook a large-scale effort to demonstrate that the modular assembly method of ZFN synthesis has a significantly higher failure rate than previously reported in the literature. This strongly suggested that engineering of ZFNs should better account for context-dependent effects among zinc fingers. The second advance reported in this dissertation is a method for biasing repair of zinc finger protein-induced DNA breaks toward homology-driven rather than error-prone repair in the presence of a donor template. Catalytically inactivating one monomer of a ZFN dimer results in a zinc finger nickase (ZFNickase) whose cleavage preference is directed at only one DNA strand. In human cell reporter assays, these ZFNickases exhibit a higher likelihood of repair by
Corrections to “Formula for the Field Excited in a Rectangular Cavity with an Electrically Large Aperture” [Feb 12 188-192]

The author notes that a closer inspection of Ref. 6 of the above-named article [ibid., vol. 54, no. 1, pp. 188-192, Feb. 2012] indicates that he misread the approximations made in Ref. 6 for the electric and magnetic polarizability dyadics of a large aperture. Therefore, several equations on pages 188 and 189 are corrected. The author maintains that these corrections do not affect equation (12), the final algebraic result of the article, do not affect the numerical results in Fig. 3, and do not have any perceptible effect on the numerical results in Fig. 2. They do not affect Fig. 2 because the original article only considered worst case incident polarization, namely the incident magnetic field parallel to the long axis of the slot.
The in vitro antibacterial activity of Morinda lucida and Acalypha wilkesiana leaf extracts against Campylobacter and Escherichia coli relevant in poultry infections

The most common cause of bacterial diarrhea in humans worldwide is infection with Campylobacter species, particularly Campylobacter jejuni and C. coli. The disease is zoonotic and domestic animals such as poultry, pigs and cattle may act as reservoirs. Colibacillosis is caused by Escherichia coli which is both a food and water borne zoonotic disease from poultry, calves and pigs. The development of resistant strains against the conventional antibiotics has reduced the efficacy of the antibiotics. Therefore, there is urgency to develop drug leads or templates with good activity against these pathogens. The antibacterial activity and safety of acetone, methanol, hot and cold aqueous leaf extracts of Morinda lucida and Acalypha wilkesiana on Campylobacter coli and selected clinical isolates of Escherichia coli was investigated in vitro using serial microdilution and cytotoxicity assays. The MIC values of selected plant extracts against the test organisms generally ranged from 0.03 to 2.50 mg/ml. MIC values of the acetone extracts ranged from 0.03 to 0.46 mg/ml, methanolic extract MICs ranged from 0.15 to 0.78 mg/ml, cold aqueous extract MICs ranged from 0.03 to 2.50 mg/ml while MICs of the hot aqueous extracts ranged from 0.03 to 1.25 mg/ml. The MIC of the positive control, gentamicin, against Campylobacter species ranged from 0.001 to 0.62 mg/ml while those of Escherichia isolates were extremely promising, ranging from 0.0002 to 0.001 mg/ml. The LC50 values of the acetone and cold aqueous extracts of Morinda lucida against the intestinal CaCo‐2 cell line were 0.46 and 0.58 mg/ml respectively while those of acetone, methanolic and hot aqueous extracts of Acalypha wilkesiana were 1.56, 0.11 and 0.19 mg/ml respectively. The selectivity index (SI) values of the acetone extract of Morinda lucida ranged from 2.55 to 9.20 while those of the cold aqueous extracts ranged from 0.23 to 19.33 with the acetone extract having better SI than the cold aqueous extract. The SI values of the acetone extract of Acalypha wilkesiana ranged from 2.22 to 52, methanolic extract ranged from 0.14 to 0.73 and hot aqueous extract ranged from 0.15 to 6.33 with the acetone extract having the best SI relative to cold aqueous, methanolic and hot aqueous extracts of both plant extracts, indicating that the observed antimicrobial activity was not due to toxicity to mammalian cells. These results highlight the potential of Morinda lucida and Acalypha wilkesiana as an alternative for treatment of campylobacteriosis and colibacillosis in poultry. However, in vivo data is necessary to determine the potential usefulness of these plant species
Standpoint Theory

Standpoint theory is an epistemology, an account of the evolution of knowledge and strategies of action by particular collectivities in specific social relations in given periods. The concept derives from Karl Marx’s exegesis of class relations in capitalism. The historical development of capitalism as a mode of production involved the disintegration of feudal hierarchies and their gradual replacement by a new class system. In the last few pages of Volume Three of Capital Marx writes, ‘We have seen that the continual tendency and law of development of the capitalist mode of production is more and more to divorce the means of production from labour, and more and more to concentrate the scattered means of production into large groups, thereby transforming labour into wage-labour and the means of production into capital’ (Marx 1959:885, first published in 1985). Thus, though land-owners remained in existence in the new era as a third class, it was the proletariat and the bourgeoisie – dynamic, mutually dependent, locked in antagonism that were definitive of capitalism.
PRODUKSI UDANG DAN POLA MUSIM PENANGKAPANNYA DI PERAIRAN KABUPATEN PANGKEP

Shrimp is a type of crustacean and is included in the marine fishery commoditywhich has important economic value and is currently hunted by fishermen and iscommonly found in coastal waters. The purpose of this study was to determine the ShrimpProduction and Seasonal Catching Pattern in the Waters of Pangkep Regency. Itsusefulness is as a foundation material in the use of shrimp resources in the waters ofPangkep Regency. Data collected consists of primary data and secondary data. Primarydata is obtained by direct observation in the field through a field survey method (visualrecall) to portray the conditions of crab resources. While secondary data was collectedfrom the relevant agencies according to the attributes that will be reviewed and recordeddata from collecting fishermen in the coastal areas and small islands of PangkepRegency. Shrimp production from trammel net and mini trawl catches in the waters of theSigeri District of Pangkep Regency in 2015 consisted of 706 tons of white shrimp anddogol shrimp 4,481 tons, while in 2016 706 tons of white shrimp and dogol shrimp 4,481tons. Analysis of the percentage of shrimp fishing season index in the waters of PangkepRegency, occurred in January, February, March and April. The highest percentage offishing season index occurs in January each year.
Strategies for Effective Management of Health and Safety in Confined Site Construction

Purpose: The overall aim of this research is to identify and catalogue the numerous managerial strategies for effective management of health and safety on a confined, urban, construction site. Design/Methodology/Approach: This is achieved by utilising individual interviews, focus groups discussion on selected case studies of confined construction sites, coupled with a questionnaire survey. Findings: The top five key strategies include (1) Employ safe system of work plans to mitigate personnel health and safety issues; (2) Inform personnel, before starting on-site, of the potential issues using site inductions; (3) Effective communication among site personnel; (4) Draft and implement an effective design site layout prior to starting on-site; and (5) Use of banksman (traffic co-ordinator) to segregate personnel from vehicular traffic. Practical Implication: The construction sector is one of the leading industries in accident causation and with the continued development and regeneration of our urban centres, confined site construction is quickly becoming the norm - an environment which only fuels accident creation within the construction sector. Originality/Value: This research aids on-site management that requires direction and assistance in the identification and implementation of key strategies for the management of health and safety, particularly in confined construction site environments.
Attitude Estimation of a Motorcycle Via Unscented Kalman Filter

Abstract In this work the problem of attitude estimation of a motorcycle is studied. A Kalman Filter approach is used and the performance of the Extended Kalman Filter and the Unscented Kalman filter are compared. The estimation accuracy and robustness have been tested both with simulated and experimental data to show which are the advantages of the Unscented Transformation.
Resolving Contract Disputes Based on Misrepresentations

This paper describes in a clear and understandable way the primary rules of law that are applied to construction contract disputes involving the misrepresentation of concealed or subsurface conditions. The rules are based on the judicial inquiries derived from more than 45 appellate court decisions. The rules are presented in the form of questions to be asked by contractors and contract administrators. The application of these questions should result in a correct determination of the dispute. The questions are organized in an easy-to-understand flow chart. The roles of the soil report and site visit and disclaimers clauses are also explained. The rules were tested using another 10 case decisions. The results show considerable consistency in the law and that the outcome is entirely dependent on the facts.