Miracle-dz/UniFAR-FTUs huggingface dataset:
Comparison of Gingival and Dental Indices in Lactating and NonLactating Mothers During First 6 Month After Delivery

Objective: To compare gingival and dental health indicesbetween breastfeeding and non-breastfeeding women during the first 6-month period after childbirth. Material and Methods: In this longitudinal study, 25 lactating mothers and 25 non-lactating mothers who had delivered a month ago were examined. The groups were identical in terms of educational level, age, income, and delivery time. Periodontal and dental indices including Pocket Depth (PD), Gingival Index (GI), Clinical Attachment Level (CAL), Bleeding on Probing (BOP) and DMFT were checked initially and after 2-4-6 months. Data were presented with the use of descriptive statistics (means, standard deviations, and frequencies). The gingival health parameters were compared between the two groups with the use of Chi-square, Wilcoxon, and Kruskal-Wallis tests. Results: Evaluation of PD showed that in the breastfeeding mothers increased from 1.97 mm at baseline to 2.44 mm after six months, while in the non-breastfeeding mother, the PDs increased from 2.03 mm at baseline to 2.11 mm after six months and at the 6-month interval, the PDs were significantly higher in the breastfeeding mothers (p>0.001). In breastfeeding mothers, the rate of dental caries was 12.68, with 11.52 in non-breastfeeding mothers (p>0.05). The rates of white spots in breastfeeding and non-breastfeeding mothers were 1.64 and 0.88, respectively. The degree of CAL and the rate of GI were similar between the two groups of mothers. Conclusion: Some periodontal indices (Pocket Depth and Bleeding on Probing) in lactating mothers were significantly higher than non-lactating mothers others (Clinical Attachment Level and Gingival Index) were similar. There were no significant differences in dental indices between lactating and non-lactating mothers. However, the rate of the white spot was more in the lactating group. Breastfeeding can be one of the risk factors in gingival inflammation and dental caries.
Aerobic Microbiological Surveillance of Operation Theatre from a Tertiary Care Hospital, Kolhapur

Microbial contamination in the operation theatre is generally associated with a risk of post operative surgical site infection (SSI). It is the second most common cause after the urinary tract infection in hospitals. It is caused by endogenous microbial flora or exogenous microbial flora (OT environments) 3 . Evaluation of quality of air and various surface swabs for microbial counting and proper infection control management plays a crucial role in the control of post operative SSIs in hospitals and prevent extended patient stay in hospitals for treatment 4 . The aim of the International Journal of Current Microbiology and Applied Sciences ISSN: 2319-7706 Volume 8 Number 10 (2019) Journal homepage: http://www.ijcmas. com
Dose-Dependent Anticonvulsant and Protective Effects of Metformin in Kainate Induced Temporal Lobe Epilepsy

Introduction: Metformin, the most commonly prescribed antidiabetic drug, has been shown to be effective in controlling seizures in some studies. However, there are some reports of proconvulsant activity of metformin in diabetic patients. The aim of the present study was to investigate the effects of metformin dosage on anti-seizure and neuronal protective activity. Method: Male Wistar rats were randomly divided into 5 groups as follows: 1-control/vehicle group, 2Kainic acid (KA), 3-metformin+KA (50 mg/kg), 4-metformin+KA (100 mg/kg), 5metformin+KA (200 mg/ kg). Temporal lobe epilepsy (TLE) was induced by injection of 0.5 μg kainite into the left lateral ventricle. Metformin was administered orally for two weeks before the induction of TLE. Results: We found that metformin at higher doses (100 and 200 mg/ kg) significantly suppressed the progression of seizure in TLE and ameliorated the neuronal loss in the hippocampus induced by KA. However, the low dose of metformin had no effect. Conclusion: We concluded that metformin may be a potential agent for the treatment of epilepsy and seizure and this effect is dose-dependent.
Mutation spectrum in GNAQ and GNA11 in Chinese uveal melanoma

Abstract Uveal melanoma is the most common intraocular cancer in the adult eye. R183 and Q209 were found to be mutational hotspots in exon 4 and exon 5 of GNAQ and GNA11 in Caucasians. However, only a few studies have reported somatic mutations in GNAQ or GNA11 in uveal melanoma in Chinese. We extracted somatic DNA from paraffin-embedded biopsies of 63 Chinese uveal melanoma samples and sequenced the entire coding regions of exons 4 and 5 in GNAQ and GNA11. The results showed that 33% of Chinese uveal melanoma samples carried Q209 mutations while none had R183 mutation in GNAQ or GNA11. In addition, seven novel missense somatic mutations in GNAQ (Y192C, F194L, P170S, D236N, L232F, V230A, and M227I) and four novel missense somatic mutations in GNA11 (R166C, I200T, S225F, and V206M) were found in our study. The high mutation frequency of Q209 and the novel missense mutations detected in this study suggest that GNAQ and GNA11 are common targets for somatic mutations in Chinese uveal melanoma.
Shoulder MRI in diagnostic evaluation of shoulder joint instability: A comparison with shoulder arthroscopy

Background: Shoulder joint is an extremely mobile joint with reduced stability. Pain and discomfort due to shoulder joint instability is common cause of orthopedic referrals in young individuals. Diagnostic Arthroscopy is the gold standard in evaluation and planning of definitive repair surgeries. Recent advancements in MR technology with increased accessibility of the general population to MR facilities have enabled non-invasive detection of pathologies associated with shoulder instability. The present study was aimed at determining the diagnostic value of shoulder MRI in shoulder instability as compared to arthroscopy. Materials and Methods: MRI and subsequent arthroscopic evaluation of 182 patients with shoulder pain and instability admitted to a busy orthopedic referral center was done after performing adequate clinical examination and necessary investigations. Results: Sensitivity and specificity of MRI was 95.87% & 89.41%, for detection of Bankart’s lesion, 98.24% & 93.24% respectively for Hill Sach’s lesion and 86.36% & 97.37% respectively for SLAP tears. High sensitivity and specificity was also found for rotator cuff tears. Conclusion: MRI can give an adequate information with regards to the pathology involved in shoulder instability and can help provide valuable input in planning of repair surgeries and can very well help to avoid unnecessary arthroscopic procedure.
Long-term Oncologic Outcome of Postoperative Complications After Colorectal Cancer Surgery

Purpose The impact of postoperative complications on long-term oncologic outcome after radical colorectal cancer surgery is controversial. The aim of this study was to examine the risk factors and oncologic outcomes of surgery-related postoperative complication groups. Methods From January 2010 to December 2010, 310 patients experienced surgery-related postoperative complications after radical colorectal cancer surgery. These stage I–III patients were classified into 2 subgroups, minor (grades I, II) and major (grades III, IV) complication groups, according to extended Clavien-Dindo classification system criteria. Clinicopathologic differences between the 2 groups were analyzed to identify risk factors for major complications. The diseasefree survival rates of surgery-related postoperative complication groups were also compared. Results Minor and major complication groups were stratified with 194 patients (62.6%) and 116 patients (37.4%), respectively. The risk factors influencing the major complication group were pathologic N category and operative method. The prognostic factors associated with disease-free survival were preoperative perforation, perineural invasion, tumor budding, and receiving neoadjuvant therapy. With a median follow-up period of 72.2 months, the 5-year disease-free survival rates were 84.4% in the minor group and 78.5% in the major group, but there was no statistical significance between the minor and major groups (P = 0.392). Conclusion Advanced cancer and open surgery were identified as risk factors for increased surgery-related major complications after radical colorectal cancer surgery. However, severity of postoperative complications did not affect disease-free survival from colorectal cancer.
Modified McKeown procedure with uniportal thoracoscope for upper or middle esophageal cancer: initial experience and preliminary results.

Background Uniportal video-assisted thoracic surgery (VATS) resections are of increasing interest in many thoracic surgery departments. With each experience in VATS lobectomy, we have incrementally improved the less invasive techniques in esophagectomy. Here, we report the preliminary results and feasibility of a modified McKeown procedure with uniportal thoracoscopy for upper or middle esophageal cancer in our institution. Methods Between March 2015 and May 2016, modified uniportal McKeown procedure with uniportal thoracoscopy for upper or middle esophageal cancer was attempted in 44 patients in our institution. Results Of the patients treated with uniportal thoracoscopy and laparoscopy, no patients were converted to open procedures, and all had a complete resection. The mean operative time was 408±34 min (range, 394-495 min). The mean thoracic operation was 163±16 min (range, 135-199 min). The mean blood loss was 245±102 mL (range, 100-450 mL). The mean number of lymph nodes resected was 24 (range, 14-36). The mean ventilator usage of the patients after surgery was 0.3±0.6 days, and the mean intensive care stay was 1.6 days (range, 1 to 7 days). The mean hospital stay was 11.8 days (range, 7 to 22 days). Major complications developed in 2 patients, both of whom had to undergo tracheotomy due to respiratory failure. No patients died of complications postoperatively, and none had clinically signiﬁcant anastomotic leaks. Conclusions Modified McKeown minimally invasive esophagectomy (MIE) with uniportal thoracoscopy seems to be a feasible option for patients with upper or middle esophageal cancer. Larger studies with longer follow-up are needed to further investigate this approach.
Autoantibody-mediated desialylation impairs human thrombopoiesis and platelet lifespan

Immune thrombocytopenia is a common bleeding disease caused by autoantibody-mediated accelerated platelet clearance and impaired thrombopoiesis. Accumulating evidence suggests that desialylation affects platelet lifespan in immune thrombocytopenia. Herein, we report on novel effector functions of autoantibodies from patients with immune thrombocytopenia, which might interfere with the clinical picture of the disease. Data from our study show that a subgroup of autoantibodies is able to induce cleavage of sialic acid residues from the surface of human platelets and megakaryocytes. Moreover, autoantibody-mediated desialylation interferes with the interaction between cells and extracellular matrix proteins leading to impaired platelet adhesion and megakaryocyte differentiation. Using a combination of an ex vivo model of thrombopoiesis, a humanized animal model, and a clinical cohort study, we demonstrate that cleavage of sialic acid induces significant impairment of the production, survival as well as function of human platelets. These data may indicate that prevention of desialylation should be investigated in the future in clinical studies as a potential therapeutic approach to treat bleeding in immune thrombocytopenia.
Endodontic treatment of a large periapical cyst with the aid of antimicrobial photodynamic therapy - Case report

Introduction: Periapical cysts, especially those of great extension, represent a challenge for endodontics, since they are not repaired with traditional treatment. The aim of this case report was to evaluate the effectivity of antimicrobial photodynamic therapy “aPDT” when associated with calcium hydroxide Ca(OH)2 in treating such cysts. Case report: A 40-year-old female patient complained of bulging in the upper anterior region of the mouth. The clinical examination showed an extensive swollen periodontal area, painful with digital palpation, with a negative response to thermal tests on teeth 11 and 21. After traditional treatment, the canals of 11 and 21 were filled with photosensitizer methylene blue 0.005% pre irradiation time (PIT) of 5 minutes and irradiation by low power diode laser with visible red wavelength (660 nm) during 2 minutes without intervals, using an optical fiber delivering system with a helical movement from apical to cervical. Then the canal were filled with Ca(OH)2 paste for 45 days being changed each 15 days, and repeating the radiation. Results: After 45 days, the patient already had a bulging remission, with painless resistance to apical pressure in the region and signs of bone repair at the radiographic examination, and total absence of signs or symptoms. Conclusion: the association of aPDT with Ca(OH)2 paste is effective in treating of periapical lesions of great extension and avoid surgical treatment.Keywords: Antimicrobial; Calcium hydroxide; Diode Laser; Periapical cysts; Photodynamic Therapy; Root canal treatment.
Association Between Lipoprotein(a) and Risk Factors of Atherosclerosis in Russian Population (Data of Observational ESSE-RF study)

Experimental and clinical data indicate a significant contribution of lipoprotein(a) (Lp[a]) to the atherogenesis. However, the pathophysiological mechanisms of this relationship are not fully understood.Aim. To investigate the distribution of Lp(a) in the population of the regions participating in the Study “Epidemiology of Cardiovascular Diseases in the Regions of the Russian Federation” (ESSE-RF) and to evaluate its associations with cardiovascular risk factors.Material and methods. Representative samples of the male and female population of 7 regions of the Russian Federation, aged from 25 to 64 years, enrolled in the multi-center cross-sectional epidemiological study were analyzed. A total of 10332 people were examined, of whom 3732 were men (36.0%) and 6600 were women (64.0%), the average age was equal in both sexes.Results. The mean value of Lp(a) reached 22.4 mg/dl (standard deviation 21.3 mg/dl) and significantly differed from the median (11.1 mg/dl; interquartile range from 3.9 to 20.2 mg/dl), forming the right-skewed distribution in both male and female population. Lp(a) levels were statistically significantly correlated with the level of low-density lipoproteins cholesterol (LDL-C), ароВ/аpoAI and total cholesterol. Notably, the odds ratios were growing by quintiles, and increased along with increasing lipid values (p<0.0001). Lp(a) levels were also positively associated with high-sensitivity C-reactive protein (hs-CRP) and negatively correlated with blood concentration of glucose and triglycerides (TG). There were no associations with body mass index, waist circumference and smoking status.Conclusion. According to the ESSE-RF data, there are significant positive associations of Lp(a) with the LDL-C level, the ароВ/аpoAI ratio, total cholesterol, and hs-CRP. Negative associations are established with glucose and TG levels. The future studies should be planned with the notion of the Lp(a)’s right-skewed distribution type.
Advances in the Surgical Management of Ankle Fractures

Ankle fractures are one of the most common injuries treated by orthopedic surgeons worldwide. However, operative indications, techniques, and reported outcomes following operative fixation vary widely in the literature. This evidence-based review focuses on recent advances in the operative management of ankle fractures including arthroscopic-assisted surgery, deltoid ligament complex repair, expanded indications for posterior malleolus fixation, fibula intramedullary nailing, and dynamic syndesmosis repair. Level of Evidence: Level V, expert opinion.
Presentation and outcomes of early and late onset neonatal sepsis in a Nigerian Hospital

Background Neonatal Sepsis remains a major cause of morbidity and mortality in neonates despite great advances in antimicrobial therapy and life support measures. Objectives To compare the aetiology, risk factors, presentation and outcomes of care between early onset neonatal sepsis (EOS) and late onset neonatal sepsis (LOS). Methods Bacterial isolates were identified using blood cultures and antibiotic susceptibility testing was done using disc diffusion method. The risk factors, clinical presentation, laboratory findings and neonatal outcomes of the babies with EOS were compared with LOS. Statistical significance was set at P <0.05. Results Neonatal Sepsis was responsible for 16% of Special Care Baby Unit (SCBU) admissions. Of the 72 babies with sepsis, 56 (77.8%) had EOS as against 16 (22.2%) who had late-onset sepsis. Low birth weight (p=0.01) and perinatal asphyxia (p=0.01) were significantly associated with EOS while for LOS, delivery outside the health facility (p=0.01) was the only significant risk factor. Respiratory distress was more significantly observed in EOS (p = 0.01). Neonatal deaths occurred in 32% of babies with EOS while all babies with culture positive LOS survived. Conclusion Early onset neonatal sepsis is associated with high likelihood of neonatal mortality. Unsupervised delivery, birth asphyxia and low birth weight are risk factors associated with neonatal sepsis. Efforts to ensure supervised hospital delivery and improvement in neonatal resuscitation may reduce the incidence of neonatal sepsis and its attendant complications.
Effect of Clinical Pathway on Satisfaction of Patients Undergoing Thyroid surgery

The patient satisfaction is a health care outcome indicator. The clinical pathway (CP) has evolved as an important tool for enhancing efficient healthcare. The aim of the study was to measure the effect of CP implementation on satisfaction of hospitalized patients undergoing thyroid surgery. The study was conducted at the Al-Thawra Modern General Hospital which is located in Sana'a capital of Yemen. The consecutive patients admitted between June 2014 and October 2014, were enrolled to the conventional care group (n=30) and the consecutive patients admitted between November 2014 and March 2015, were recruited to the CP group (n=30). Pre-operative assessment and Patient's satisfaction questionnaire tools were used for data collection. The results revealed that the patients in the CP group had higher level of satisfaction than the conventional care group (Mean±SD: 109.9±15.4 versus 83.6±14.6). The results also revealed that there were strong negative correlation between CP outcomes (length of hospital stay and complications) and patient satisfaction (respectively, r =-0.514, r = -0.76) Conclusion: The implementation of CP in the management of patients undergoing thyroid surgery had increased significantly the level of patients' satisfaction regarding admission, patient care, education, length of stay and complications.
Screening for At-Risk Substance Use and Behavioral Health Concerns in University Primary Care

Harmful substance use is a prevalent and under-treated public health problem, with use of alcohol, tobacco, and illicit drugs among the top preventable causes of death in the United States. The unmet need for treatment is particularly pronounced among young adults, for whom university primary care is an important venue for early detection and intervention. Although a number of different multi-substance use screens have been developed for primary care settings, none have been validated in university primary care. Other behavioral health concerns are also highly prevalent among college students, although little is known regarding how behavioral risk factors co-occur in this setting. Accordingly, this study aimed to extend research on the validity of the 4-item Substance Use Brief Screen (SUBS) in a university primary care setting. The diagnostic utility of the SUBS was also compared to an established screen for at-risk drinking, the Alcohol Use Disorder Identification Test – Consumption (AUDIT-C). Finally, this study described prevalence rates and identified cluster profiles of multiple risk factors, including atrisk substance use, behavioral health concerns, and body mass index. Participants (n = 100) were recruited from Syracuse University Health Services to complete self-report screens and a structured interview. Results support the construct validity and utility of the SUBS in university primary care, with cut-off scores of 1 for tobacco and nonmedical prescription drug use, and 2 for at-risk alcohol and illicit drug use. Results also suggest that behavioral health risk factors commonly co-occur, thereby supporting the development of brief, combined interventions targeting multiple risk factors in university primary care. SCREENING FOR AT-RISK SUBSTANCE USE AND BEHAVIORAL HEALTH CONCERNS IN UNIVERSITY PRIMARY CARE by Clare E. Campbell B.A., State University of New York at Geneseo, 2010 M.S., Syracuse University, 2015 Dissertation Submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Clinical Psychology
HIV Risk-Reduction in Nonmarital Sexual Behavior Among Young Maldivian Males

HIV Risk-Reduction in Nonmarital Sexual Behavior Among Young Maldivian Males by Mohamed Elmunir Ahmed Safieldin MBA, Hull University, 2006 B.Sc., University of Khartoum, 1984 Dissertation Submitted in Partial Fulfillment of the Requirements for the Degree of Doctor of Philosophy Public Policy Administration
Kadar HbA1c pada Pasien Wanita Penderita Diabetes Mellitus Tipe 2 di Rsud Dr. Doris Sylvanus Palangka Raya

Laboratory tests recommended by the ADA as a supportive examination for diagnosing DM are Hemoglobin Adult 1C (HbA1c), HbA1c examination can be used as a reference for monitoring diabetes mellitus because HbA1c can provide clearer information about the true condition in people with diabetes mellitus. HbA1c examination is an examination that reflects the average blood glucose level over a period of 2-3 months. The purpose of this study was to determine the description of HbA1c in female patients suffering from type 2 diabetes mellitus in RSUD dr. Sylvanus Palangka Raya. This research was conducted using a cross sectional study method with accidental sampling technique. The sample used in this study was patients suffering from type 2 diabetes mellitus in RSUD dr. Doris Sylvanus Palangka Raya taken by 15 people. Then examined using the boronate affinity method. The results obtained by the HbA1c category were 4 people (26.67%) good, 6 people (40%) medium and 5 people (33.33%) bad.
Monitoring the Treatment of Hepatitis C Viral Infection by Molecular Techniques

The prevalence of Hepatitis C viral infection in Egypt is the highest rate in the world. It is a major public health problem in Egypt. The objective of this study was to detect the clearance of HCV-RNA in Egyptian patients who were recommended for combination therapy of pyglated interferon α 2a and ribavirin (PEG-interferon/Ribavirin). Ninety-five positive HCV-IgG cases were tested for HCV-RNA at baseline and at weeks 4, 12, 24, 48 and 72 of treatment with PEG-interferon α 2a/Ribavirin. The correlations between the viral parameters during and after treatment were evaluated. Patients recommended receiving PEG-interferon 2a/ribavirin combination therapy showed high response rate determined as 71.9% achieved Sustained Virological Response (SVR) from total patients, and 71.4% from patients who received 48 weeks therapy. In general, the employment of TMA provided us the accuracy of results with confidence in our work. There was a significant relation (p < 0.001) between results of Transcription mediated amplification (TMA) and response to therapy that indicate to positive correlation. The development of sensitive accurate assays for HCV-RNA detection and quantification is necessary to improve not only the assessment of the response to antiviral therapy but also our understanding of the mechanism underlying antiviral resistance.