Miracle-dz/UniFAR-FTUs huggingface dataset:
Ischemic Stroke Severity and Mortality in Patients With and Without Atrial Fibrillation

Background Our objective was to investigate stroke severity and subsequent rate of mortality among patients with and without atrial fibrillation (AF). Contemporary data on stroke severity and prognosis in patients with AF are lacking. Methods and Results First‐time ischemic stroke patients from the Danish Stroke Registry (January 2005–December 2016) were included in an observational study. Patients with AF were matched 1:1 by sex, age, calendar year, and CHA2DS2‐VASc score with patients without AF. Stroke severity was determined by the Scandinavian Stroke Scale (0–58 points). The rate of death was estimated by Kaplan‐Meier plots and multivariable Cox regression. Among 86 458 identified patients with stroke, 17 205 had AF. After matching, 14 662 patients with AF and 14 662 patients without AF were included (51.8% women; median age, 79.6 years [25th–75th percentile, 71.8–86.0]). More patients with AF had very severe stroke (0–14 points) than patients without AF (13.7% versus 7.9%, P<0.01). The absolute rates of 30‐day and 1‐year mortality were significantly higher for patients with AF (12.1% and 28.4%, respectively) versus patients without AF (8.7% and 21.8%, respectively). This held true in adjusted models for 30‐day mortality (hazard ratio [HR], 1.40 [95% CI, 1.30–1.51]). However, this association became nonsignificant when additionally adjusting for stroke severity (HR, 1.10 [95% CI, 1.00–1.23]). AF was associated with a higher rate of 1‐year mortality (HR, 1.39 [95% CI, 1.32–1.46]), although it was mediated by stroke severity (HR, 1.15 [95% CI, 1.09–1.23], model including stroke severity). Conclusions In a contemporary nationwide cohort of patients with ischemic stroke, patients with AF had more severe strokes and higher mortality than patients without AF. The difference in mortality was mainly driven by stroke severity.
The Social Accounting Matrix and the Socio-Demographic Matrix-Based Approaches for Studying the Socioeconomics of Ageing

In looking for empirical evidence about the activity of countries, a proposal is made for studying (measuring and modelling) the activity of countries through the use of Social Accounting Matrices (SAMs) and Socio-Demographic Matrices (SDMs). SAMs and SDMs are presented as tools that have specific features for conducting studies in several different areas, particularly in the Socio-Economics of Ageing, as well as for supporting policy decision processes. Based on methodological principles that are derived mainly from the works of Richard Stone, emphasis is placed on the desirability of working in a matrix format, which includes not only people (SDM), but also, at the same time, activities, products, factors of production and institutions (SAM). This is considered to be a way of capturing the relevant network of linkages and the corresponding multiplier effects for the subsequent modelling of the activity of the countries studied. The exposition of this proposal is accompanied by an example applied to Portugal.
A Behavioral Heterogeneous Agent New Keynesian Model

Recent empirical evidence has led to a rethinking of how monetary policy is transmitted to the economy: (i) monetary policy influences household consumption to a large extent through indirect general equilibrium effects; (ii) households with higher marginal propensities to consume are on average more exposed to monetary policy; (iii) announcements of future monetary policy changes have relatively weak effects on current economic activity; and (iv) the effective lower bound on nominal interest rates does not lead to large instabilities. We develop a New Keynesian model with household heterogeneity and bounded rationality in the form of cognitive discounting that accounts for all these facts simultaneously. In contrast to existing models, we jointly account for these facts without having to rely on a specific monetary or fiscal policy. We use our model to revisit the policy implications of inflationary supply shocks and find a pronounced trade-off between price stability on the one hand, and fiscal and distributional consequences on the other hand. Monetary policy has to increase interest rates more strongly than under rational expectations to fully stabilize inflation. This leads to a stronger increase in consumption inequality and has larger fiscal implications. When monetary policy follows a standard Taylor rule, inequality declines after the negative supply shock. Inflation, however, increases substantially due to a novel amplification channel driven by cognitive discounting, household heterogeneity and the interaction of the two.
Impact of Human Papilloma Virus (HPV) Status on Well Established Risk Profile of Oral Cancer in Sri Lanka

Background: There is a calamitous need to explore the impact of HPV on well-established risk profile of oral cancer which is poorly understood. Aim: Prioritizing this situation, we aimed to investigate the impact of HPV on well-established risk profile of oral cancer in Sri Lanka, using a representative sub sample consisted of 29 oral squamous cell carcinoma cases(OSCC) and 25 fibro epithelial polyps (FEP), from a large case control study conducted in Sri Lanka. Methodology: Incisional biopsies of cases and excisional biopsies of controls were collected, transported, stored at =80 0 C and dispatched as frozen tissues. DNA was extracted from frozen specimens, using the Gentra Puregene Tissue kit (Qiagen, Germany), solid tissue protocol according to the manufacturer’s instructions. Nested PCR was performed to detect HPV and HPV geno types were discovered by sequencing. Results: HPV was detected in 4/54 (7.4 %) of overall samples. Upon sequencing, high risk HPV α 9 and HPV 31 were detected in controls and not in the HPV positive OSCC case. between cases and controls*. Moreover, statistically significant difference was obtained in mean ages of cases and controls. (p= 0.0001)*. Cases were older than controls. Conclusion: There was no impact of HPV on established risk profile of oral cancer in Sri Lanka. This high light the emerging importance of investigating the HPV status of young OSCC cases without known aetiology.
The association between acute lower abdominal pain over a previous caesarean scar and uterine rupture

Abstract Pregnant women with previous caesarean delivery might suffer from acute lower abdominal pain located at the site of previous caesarean scar (CS). The association between this complaint and uterine rupture (UR) is not fully understood. Therefore, we aimed to examine the risk of UR in women with acute persistent abdominal pain (APAP) over a previous CS and to investigate all the women with UR, with or without APAP and with or without previous CS, in order to determine risk factors, clinical presentation and management. We performed a retrospective analysis on two study groups: women who had APAP over previous CS and women who had UR. We found an incidence of UR in patients with APAP over the previous CS was 0.7%; which doubled the total UR rate among women with previous caesarean in our medical centre (0.35%). Forty percent of the women with APAP over a previous CS had preterm delivery. Twenty percent of the cases of UR occurred in preterm weeks. To conclude, APAP over a previous CS is associated with a doubled risk of UR. Considering this symptom as a preliminary sign of UR might lead to elevated rate of iatrogenic preterm deliveries. Impact statement What is already known on this subject? Women with UR may present with abdominal pain which may vary from non-specific mild discomfort to severe acute abdominal pain. Additionally, these women may suffer from acute persistent abdominal pain (APAP) located over the previous caesarean scar. The clinical significance of APAP in these women has not been fully investigated. What do the results of this study add? Lower abdominal pain located at the site of previous CS is associated with a doubled risk of UR. Considering this complaint as a major sign of UR might lead to an elevated rate of iatrogenic preterm deliveries. What are the implications of these findings for clinical practice and/or further research? Further studies are needed to explore whether women with a single complaint of APAP over CS could be managed expectantly and even offered a trial of labour after caesarean delivery (CD).
BREATH HOLDING TIME AND OXYGEN SATURATION IN COVID AFFECTED NURSING STUDENTS-A COMPARATIVE STUDY

Objective: The present study is based on a novel approach of validated breath-holding technique and efficiency of SpO2 in the adverse COVID-19 outcomes and comparison with normal subjects. Methods: It is a prospective observational study conducted in residential/private nursing colleges, St. Luke’s School and College of Nursing and Smt. Vijaya Luke’s College of Nursing, Visakhapatnam during the period July 2021. Fifty-three student nurses affected with mild COVID-19, 35 student nurses affected with moderate COVID-19, aged 18–23 years were enrolled after taking thorough history about COVID-19 that is after 2 months of complete recovery. They were classified based on the symptom history in which the subjects without symptoms or mild symptoms were taken as mildly affected, whereas subjects with severe symptoms with mild fluctuations in SpO2 who didn’t require hospitalization were classified as moderately affected. The study included 109 normal control cases who are never affected with COVID-19 viral infection. In all the subjects, the oxygen saturation was measured using pulse oxymeter and their Breath holding times were also measured using standard protocols. Results: The mean value of BHT was significantly reduced from normal 16.7339±3.4 to 12.8571±5.1 (p<0.05) in moderate cases. When oxygen saturation levels were compared before and after the breath holding in normal, mild and moderate cases the results were significant. However, when the oxygen saturation levels were compared between normal and mild COVID-19 cases the values were insignificant (p=0.4) and at the same time when the oxygen saturation levels were compared between normal and moderate COVID-19 cases the values were significant (p=0.0001). Conclusion: According to the findings, breath-holding does not need greater energy expenditure or cardiac output, and it eliminates walking and the related contamination of bystanders as occurring with pulse oximeter. Breath holding time is a determinant of respiratory capacity, when used as parameter helps in assessing the progression of lung injury, it gives an idea about respiratory fitness especially in this COVID era. Breath holding time and fluctuations in SpO2 when used conjointly we can assess degree of lung damage so that further treatment such as the continuity of medication, practicing of breathing exercises with or without medical treatment can be planned. This simple non-invasive tool can be used for the self-assessment of improvement in post-Covid patients. Future validation studies validate this hypothesis, measurement of these basic, innovative surrogates requires minimum inventory (i.e., a means to record oximetry and a timing device) and could feasibly provide a useful way to evaluate risks of future deterioration under under-resourced conditions.
Vitamin D and Vitamin D Receptor in Female Infertility

Objective: To investigate the possible association of serum and follicular fluids(FF) Vitamin D levels with reproductive outcomes after assisted reproductive techniques (ART). Secondly, to detect Vitamin D Receptors (VDR) in serum and follicular fluid (FF) of ovarian follicle and explore its relationship with Vitamin D levels as well as reproductive outcomes. Methodology: This study was conducted on May 2019 in Aga Khan Hospital, Karachi, Pakistan. A total of 8 infertile female subjects were conveniently recruited. Serum was collected and follicular fluid(FF) was obtained by transvaginal-guided follicular puncture; 34 hours after intramuscular administration of Human Chorionic Gonadotrophin (HCG). Vitamin D and VDR was assessed in serum as well as in FF by Paired Sample t-test. Results: Females 2 out of 8 acquired clinical pregnancy, whereas 3 had pre-clinical abortion or no pregnancy. Vitamin D and VDR were detected highest in those female patients that acquired pregnancy in comparison to the pre-clinical abortion or non-pregnant ones (p value<0.007). Serum VDR did not show any significant results in all groups Conclusion: Vitamin D in serum and FF and vitamin D receptor in serum and FF were associated with number of oocytes. High levels of VDR in FF observed in clinical pregnancy group proved our hypothesis that the presence of VDR in FF is a contributing factor for successful conception after ART success.
Irradiation test of the HCAL Forward and Endcap upgrade electronics at the CHARM facility at CERN

1 Irradiation test of the HCAL Forward and Endcap upgrade electronics at the CHARM facility at CERN Francesco Costanza, Tugba Karakaya, Ozgur Sahin, (DESY, Germany) Tullio Grassi (Univ. of MD, USA), James F Hirschauer, Don Lincoln, Nadja Strobbe (Fermilab, USA), Alexander Kaminskiy (M.V. Lomonosov Moscow State University), Danila Tlisov (Russian Academy of Sciences), Yanchu Wang (Univ. ov VA, USA)
Gene Expression Analysis of Specific Genes Related to Genomic Stability in Colon Cancer Cell Lines - A Resource for Cancer Research

Appropriate cell models are the foundation of cancer research as all the cell lines are not the same in their ability to mimic primary tumor tissue. Molecular characteristics of various cell lines can help in selecting the right cell model for biomedical studies. This study describes the gene expression profile of nine genes, include the six-protein shelterin complex, tankyrases1and 2, and CTNNB1 in three different models of human colon cancer cell lines. Also, the relative telomere length in each cell line was evaluated. All genes' expression levels were analyzed using a real-time polymerase chain reaction. Nearly all test genes were significantly highly expressed in HT-29 as compared to HCT-116 and SW-620. SW-620 record a significantly increased expression of the CTNNB1 gene (P-value < 0.01) while most genes were poorly expressed in HCT-116. A positive correlation between CTNNB1 and hTERT expression was found in HCT-116 and SW-620 but not in HT-29. Telomere was found to be of the same length in all cell. Gene expression data presented in our results can assist in selecting appropriate cell lines in colon cancer research. Unique molecular properties of various cancer cell lines should be evaluated before selecting a cell line mmodelfor research purposes.
Knowledge, Attitude and Practices Survey: COVID-19 Pandemic and its Preventive Standard Operating Procedures in College Students

Objectives: To evaluate the knowledge, attitude and practices of the undergraduate college students towards corona virus disease (COVID-19) and adoption of personal protective measures as per standard operating procedures (SOPs) stipulated by Federal government for reopening of educational institute.Methodology: This was cross sectional survey conducted at Hyderabad and Faisalabad based colleges form 25 September to 15 October 2020. Prior to the study, permission was taken from principal of concerned colleges (vide no.TSS/22/2021, Kotri Jamshoro) Structured proforma comprised of 28 questions concerning knowledge, attitude and practices toward the COVID-19 and implementation of SOPs in educational institutes was used. Questionnaire was formed on Google form and its link was shared among 200 college students of various disciplines through WhatsApp. Results from the response summary were compiled and analyzed.Results: Structured proforma was distributed among 200 undergraduate students of age range18-20 years, only 170 students’ submitted complete responses. Response rate was 85%. More than half (70.9%) of the subjects have good knowledge and positive attitude concerning COVID-19. Majority of the students (89.2%) were using masks, 88.6% were in habit of regular hand washing ,while 84.3 % of students preferred to use sanitizers, 91.6% practiced social distancing and avoided crowded places ,75.3% students avoided unnecessary travelling. 98-99% of students agreed that SOPs set by government was strictly followed in the colleges. Conclusion: Majority of the students were aware of the preventive measures for COVID outbreak. Students have positive attitude and are adequately practicing precautionary measures to avoid contracting COVID-19. SOPs are following in the colleges to alleviate the risk of spread of lethal Corona.
Retracted publications in pharmacy systematic reviews

Objective: Systematic reviews and other evidence syntheses, the pinnacle of the evidence pyramid, embody comprehensiveness and rigor; however, retracted data are being incorporated into these publications. This study examines the use of retracted publications in the field of pharmacy, describes characteristics of retracted publications cited by systematic reviews, and discusses factors associated with citation likelihood. Methods: Using data from Retraction Watch, we identified retracted publications in the pharmacy field. We identified all articles citing these retracted publications in Web of Science and Scopus and limited results to systematic reviews. We classified the retraction reason, determined whether the citation occurred before or after retraction, and analyzed factors associated with the likelihood of systematic reviews citing a retracted publication. Results: Of 1,396 retracted publications, 283 were cited 1,096 times in systematic reviews. Most (65.0%) (712/1096) citations occurred before retraction. Citations were most often to items retracted due to data falsification or manipulation (39.2%), followed by items retracted due to ethical misconduct including plagiarism (30.4%), or concerns about or errors in data or methods (26.2%). Compared to those not cited in systematic reviews, cited items were significantly more likely to be retracted due to data falsification and manipulation, were published in high impact factor journals, and had longer delays between publication and retraction. Conclusions: Further analysis of systematic reviews citing retracted publications is needed to determine the impact of flawed data. Librarians understand the nuances involved and can advocate for greater transparency around the retraction process and increase awareness of challenges posed by retractions.
MTS-OpenFresco-MATLAB hybrid simulation system construction and verification test

Seismic test is an important method to explore the structure seismic performance. This paper carries out a preliminary research of seismic hybrid simulation combined with finite element analysis. We conduct a seamless connection between OpenFresco open source experimental platform and MTS electro-hydraulic servo loading system based on CSIC and MATLAB,and then establish a MTS-OpenFresco-MATLAB hybrid simulation system initially. Several key problems during system construction,such as the establishment of data channel,the reduction of degree of freedom and boundary condition imitation of experimental element,and others are presented in detail. A verification test with a two-storey and single span planar steel frame is conducted in order to test the system performance. The single column on the left is taken as the experimental element and the single column on the left and the beam are taken as the calculative element. The results are compared with finite element results. The results show that the system is smooth circulation,stable and effective,and can be accurately reflect the mechanical properties of complex parts in structures.
The Effect of COVID-19 Pandemic on Outcome of Assisted Reproductive Technology: A Report from a Single Infertility Center

Objective: COVID-19 pandemic has affected all aspects of human life including social, economic, healthy behaviors and even individual relationships. This study aimed to investigate the effect of corona virus outbreak on assisted reproductive technology (ART) outcome. Materials and methods: In this retrospective and prospective cohort, 260 ART cycles of ovum pick up (OPU), fresh embryo transfer (ET) and frozen embryo transfer (FET) were evaluated in 223 women (from December 2019 to February 2020) and during COVID-19 outbreak (February and July 2020) in an infertility center. Primary and secondary outcomes of ART cycles including chemical and clinical pregnancy rate were evaluated. Results: The mean±SD (standard deviation) age of women was 34.17±6.56 years. Chemical and clinical pregnancy rates were 23.91% (33/138) per embryo transfer and 75.8% (25/33) per positive pregnancy test, respectively while ongoing pregnancy was seen only in 69.7% (23/33) of those with positive pregnancy test. Spontaneous abortion rate was 15.15% (5/33) per laboratory pregnancy. COVID-19 symptoms were reported in 2.83% and 15.38% of women during and after ART cycles, respectively. Conclusion: It seems that COVID-19 pandemic has not negative effect on outcome of ART cycles except for cancelation rate due to COVID-19 that increased at the beginning of COVID-19 outbreak as it was unknown at that time and awareness was limited.
Ernst Abbe's Scientific Management: Theoretical Insights from a 19th Century Dynamic Capabilities Approach

"Scientific management" is the label Frederick Taylor attached to the system of shop-floor management devised by him. In this article, we present our discovery of very different "scientific" management principles that, roughly concurrently with Taylorism, were developed by German physicist-manager Ernst Abbe and that are codified in the statutes of the Carl Zeiss foundation created by Abbe. They exhibit striking parallels to Resource- and Capability-Based Theories of the Firm, and indicate managerial challenges that warrant further theoretical elaboration. Abbe develops an account for managing a science-based firm and securing its long-term competitiveness, giving detailed prescriptions with regard to the type and scope of a firm's activities, its organizational setup, and its labor relations. We highlight some of the most characteristic features of Abbe's thought, discuss its effects on the development of the firms owned by the Zeiss foundation, and compare it to and draw out implications for present-day management theory.
Review of factors affecting canal water losses based on a meta‐analysis of worldwide data

Irrigation water conveyance relies heavily on canal networks because they transport the water cheaply. However, water losses are high, which is a major concern in the face of soaring demand and dwindling new water sources. While researchers have investigated canal water losses and water loss types at irrigation scheme level, their variability and the main factors of influence at a global scale are still not clear. Thus, this study aims to elucidate the effects of canal water flow and soil characteristics on water losses globally. Data for 1388 canal reaches from 45 published articles are used. The results confirm that evaporation is so negligibly smaller than seepage and other water loss types that it can safely be ignored when analysing major water losses from canals. The study results also confirm that canal water losses decrease with soil clay content, due to decreasing permeability. The methods used for assessing water losses show significant influence on water losses; for example, the inflow–outflow method exhibits significantly higher water losses than the ponding technique. The current study results also show that canal shape, wetted perimeter and wetted area have a significant influence on water losses. It can be concluded from the study results that consideration of the physical mechanisms of water losses and different water loss types involved is important in future studies. It is recommended that future canal water loss studies, especially those focusing on losses via evaporation, also assess the effects of factors such as canal embankment height and depth of freeboard on the losses. These results are important for water scientists, engineers and practitioners.