Miracle-dz/UniFAR-FTUs huggingface dataset:
Comparison of different methods of retinal imaging for the screening of diabetic retinopathy: a systematic review

Screening for diabetic retinopathy (DR) is recommended to detect sight‐threatening complications prior to visual loss. Early Treatment Diabetic Retinopathy Study (ETDRS) seven standard field (7SF) retinal imaging has traditionally been regarded the gold standard for DR classification, but other methods are often preferred clinically. The purpose of this systematic review was to determine whether 7SF is the most optimal screening method for DR grading, or if similar results can be achieved by other methods using a smaller field of view (<7SF) or ultra‐wide field (UWF) imaging.
The long and bright path of a lanthanide MOF: from the basics towards the application.

The development of portable, reliable, and low-cost sensors for assessing the quality of natural water sources is of high relevance in developing countries as they can serve as an intermediate solution prior to the building of permanent potable water distribution infrastructure. These sensors should be simple to operate by non-trained operators and easy to manufacture locally. Lanthanide-based Metal-Organic Frameworks (MOFs) offer a trustable platform due to their intense emission in regions of the visible spectra and their high sensitivity to fluorides in water. We chose cotton as a substrate due to its high hydrophilicity, which together with the highly porous nature of the MOF, allows for shorter reaction times. The modified cotton was characterized by XRD, SEM as well as XAFS, hence probing the presence of [Tb(BTC)6(H2O)] (Tb-BTC) attachment to cotton. Changes in the emission when Tb-BTC modified cotton was exposed to water and aqueous fluoride solutions were monitored as a function of time. We identified crystalline phase changes that correlated to structural information. Finally, we used the Tb-BTC modified cotton to build a fluoride demonstrator sensor with a linear response up to 10ppm and 0.8ppm detection limit making it suitable for drinking water analysis under international regulations.
Effect of a 7-week low intensity synchronous handcycling training programme on physical capacity in abled-bodied women

ABSTRACT This study evaluated the effect of a low-intensity norm duration synchronous handcycle wheelchair training in untrained able-bodied women. The training group (n = 9) received 7-weeks of low-intensity upper body training in an instrumented handcycle on a motor-driven treadmill (MDT), 3 × 30 min/week at 30% heart rate reserve. The control group (n = 10) received no training. Incremental handcycle tests on the MDT were used to determine peak values for oxygen uptake (VO2peak), power output (POpeak), heart rate (HRpeak), minute ventilation (VEpeak), and respiratory exchange ratio (RERpeak), submaximal values for heart rate (HR), oxygen uptake (VO2) and gross efficiency (GE) before and after training. Local perceived discomfort and rate of perceived exertion (RPE) were also assessed. Training significantly improved POpeak (+20%), HRpeak (+3%), RERpeak (+5%), submaximal GE (+21%), VO2 (−20%), VE (−33%), HR (−12%) and RPE was low (7.1 ± 0.5) (p < 0.05). No effects were found in VO2peak and VEpeak (p > 0.05). Though VO2peak did not improve, low-intensity norm duration handcycling training improved handcycling POpeak, while RPE was low. Also, GE increased, suggesting a motor control improvement. Handcycle training seems to be an appropriate exercise mode to improve physical capacity, and prevent early fatigue and overuse in untrained individuals.
Vasomotor action of androgens in the mesenteric artery of hypertensive rats. Role of perivascular innervation

Androgens may exert cardiovascular protective actions by regulating the release and function of different vascular factors. In addition, testosterone (TES) and its 5-reduced metabolites, 5α- and 5β-dihydrotestosterone (5α- and 5β-DHT) induce vasorelaxant and hypotensive effects. Furthermore, hypertension has been reported to alter the release and function of the neurotransmitters nitric oxide (NO), calcitonin gene-related peptide (CGRP) and noradrenaline (NA). Since the mesenteric arteries possess a dense perivascular innervation and significantly regulate total peripheral vascular resistance, the objective of this study was to analyze the effect of TES, 5α- and 5β-DHT on the neurogenic release and vasomotor function of NO, CGRP and NA. For this purpose, the superior mesenteric artery from male spontaneously hypertensive rats (SHR) and normotensive Wistar Kyoto (WKY) rats was used to analyze: (i) the effect of androgens (10 nM, incubated for 30 min) on the neurogenic release of NO, CGRP and NA and (ii) the vasoconstrictor-response to NA and the vasodilator responses to the NO donor, sodium nitroprusside (SNP) and exogenous CGRP. The results showed that TES, 5α- or 5β-DHT did not modify the release of NO, CGRP or NA induced by electrical field stimulation (EFS) in the arteries of SHR; however, in the arteries of WKY rats androgens only caused an increase in EFS-induced NO release. Moreover, TES, and especially 5β-DHT, increased the vasodilator response induced by SNP and CGRP in the arteries of SHR. These findings could be contributing to the hypotensive/antihypertensive efficacy of 5β-DHT previously described in conscious SHR and WKY rats, pointing to 5β- DHT as a potential drug for the treatment of hypertension.
The features of the typical traumatic brain injury patient in the ICU are changing: what will this mean for the intensivist?

PURPOSE OF REVIEW To describe the key features and epidemiology of traumatic brain injury (TBI) and how they may be changing, with an emphasis on how this may affect care in the intensive care unit. RECENT FINDINGS TBI has been traditionally perceived as occurring mainly in a younger, predominantly male population injured in high velocity motor vehicle crashes or assaults. However, there are an increasing number of patients over 65 years who have sustained a TBI secondary to low velocity falls. Considering the effects of frailty, comorbidities and extracranial injuries is important when making management decisions. Mild TBI comprises a third of those admitted and as a significant proportion may have poor outcomes secondary to their TBI they should be assessed to ensure appropriate follow-up. Multimodal monitoring may offer a way in the future to offer more personalised management to this very complex and heterogeneous patient group. SUMMARY This review highlights the urgent need to develop more age-inclusive TBI consensus management guidelines aimed at improving short- and long-term outcomes for the large and growing TBI population. Being elderly does not necessarily portend a poor outcome, and more research is needed to better triage, guide management and prognosticate on these patients.
MMR Vaccine and COVID-19: Measles Protein Homology May Contribute to Cross-Reactivity or to Complement Activation Protection

A recently published study by Jeffrey E. Gold et al. (1) presents data that strongly suggest that measles-mumps-rubella (MMR) vaccination negatively correlates with the severity of coronavirus disease 2019 (COVID-19)-related symptoms. Another study by Alba Grifoni et al. (2) demonstrated that antibody titers to spike protein in some unexposed to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) subjects may reach substantial levels, thus suggesting preexisting immunity to the coronavirus. This preexisting immunity may be due to the cross-reactivity with other antigens, for example the ones resulting from previous immunizations. Other studies reported that COVID-19 mortality is higher in countries where Mycobacterium bovis BCG vaccination is not routinely administered (3). Why previously received MMR vaccine may aid in reducing the …
Charge separation and recombination in photoexcited oligo(p-phenylene vinylene) : perylene bisimide arrays close to the Marcus inverted region

The kinetics of photoinduced intramol. charge sepn. and subsequent charge recombination of three oligo(p-phenylene vinylene)-perylene bisimide-oligo(p-phenylene vinylene) arrays has been studied using femtosecond pump-probe spectroscopy in solvents of different polarity. The redn. potentials of three donor-acceptor-donor mols. differ strongly as a consequence of the four substituents (R = 4-tert-butylphenoxy, H, or Cl) at the bay position of the central perylene bisimide unit. The expts. indicate that charge sepn. in these mols. occurs from the first excited singlet state of the perylene bisimide moiety to the charge-sepd. state (CSS) and to the lowest electronically excited state level of the charge-sepd. state (CSS*). For R = H and Cl, the rates for charge sepn. and charge recombination decrease with increasing change in the Gibbs free energy, and hence the mols. represent an exceptional example of mols. in which both charge sepn. and recombination occur close to or in the Marcus inverted region. [on SciFinder (R)]
Prostaglandin I2 signaling licenses Treg suppressive function and prevents pathogenic reprogramming.

T regulatory cells (Treg) restrain both the innate and adaptive immune systems to maintain homeostasis. Allergic airway inflammation, characterized by a type 2 (Th2) response that results from a breakdown of tolerance to innocuous environmental antigens, is negatively regulated by Treg. We previously reported that prostaglandin I2 (PGI2) promoted immune tolerance in models of allergic inflammation; however, the effect of PGI2 on Treg function was not investigated. Treg from mice deficient in the PGI2 receptor IP (IP KO) had impaired suppressive capabilities during allergic airway inflammatory responses compared to mice with PGI2 signaling was intact. IP KO Treg had significantly enhanced expression of immunoglobulin-like transcript 3 (ILT3) compared to wild-type Treg, which may contribute to the impairment of the IP KO Treg's ability to suppress Th2 responses. Using fate-mapping mice, we reported that PGI2 signaling prevents Treg reprogramming toward a pathogenic phenotype. PGI2 analogs promoted the differentiation of naïve T cells to Treg in both mice and humans via repression of β-catenin signaling. Finally, a missense variant in IP in humans was strongly associated with chronic obstructive asthma. Together, these data support that PGI2 signaling licenses Treg suppressive function and that PGI2 is a therapeutic target to enhance Treg function.
Polyvictimization, Sex Work, and Depressive Symptoms Among Transgender Women and Men Who Have Sex With Men

This article examined the association among polyvictimization, sex work, and depressive symptomology among transgender women and men who have sex with men (MSM) in India. Data comes from a cross-sectional epidemiological study with 1,366 transgender women (from three states) and 2,182 MSM participants from five states of India. Multivariate regressions were used to examine how polyvictimization and sex work are associated with depressive symptoms. In total, 70% of transgender women and 44% of MSM participants in the sample reported being in sex work; 30% of transgender women and 17% of MSM reported at least one experience of abuse in last 6 months. In bivariate analysis, transgender women in sex work were more likely to report sexual abuse, and MSM in sex work more likely to report all types of abuse (physical, sexual, verbal, and property), compared to their peers. In multivariate models (with transgender women and MSM), increase in endorsement on types of abuses (polyvictimization) and being in sex work were associated with higher odds of reporting depressive symptoms. Both models controlled for age and marital status, while the model with transgender women also controlled for gender transitioning, and the model with MSM controlled for identity typology. National intervention program on HIV risk reduction must prioritize victimization screening and crisis management as part of their work. In addition, the interventions must be responsive to the diversity of the population, including those who engage in sex work, and address issues of access and support to gender transitioning services, and focus on psychosocial interventions to reduce stress due to gender-based stigma and discrimination among transgender women and MSM.
BPF-Based Thermal Sensor Circuit for On-Chip Testing of RF Circuits

A new sensor topology meant to extract figures of merit of radio-frequency analog integrated circuits (RF-ICs) was experimentally validated. Implemented in a standard 0.35 μm complementary metal-oxide-semiconductor (CMOS) technology, it comprised two blocks: a single metal-oxide-semiconductor (MOS) transistor acting as temperature transducer, which was placed near the circuit to monitor, and an active band-pass filter amplifier. For validation purposes, the temperature sensor was integrated with a tuned radio-frequency power amplifier (420 MHz) and MOS transistors acting as controllable dissipating devices. First, using the MOS dissipating devices, the performance and limitations of the different blocks that constitute the temperature sensor were characterized. Second, by using the heterodyne technique (applying two nearby tones) to the power amplifier (PA) and connecting the sensor output voltage to a low-cost AC voltmeter, the PA’s output power and its central frequency were monitored. As a result, this topology resulted in a low-cost approach, with high linearity and sensitivity, for RF-IC testing and variability monitoring.
Is Nasal Packing Necessary After Endoscopic Dacryocystorhinostomy Without Stent and Mucosal Flaps Preservation?

Supplemental Digital Content is available in the text Objective: This study aimed to evaluate the effect of nasal packing on the surgical success and postoperative complications of endoscopic dacryocystorhinostomy (EnDCR) without using stents and mucosal flaps. Methods: The retrospective study comprised of 75 eyes of 65 consecutive patients undergoing EnDCR with the biting and removing technique. The patients were assigned to 2 groups depending on whether the biodegradable synthetic polyurethane foam was used or not (the packing group, 34 eyes; the nonpacking group, 41 eyes). At least 6 months after the EnDCR, the postoperative outcomes including anatomical and functional successes, and the postoperative complications such as synechia, granuloma, and bleeding were compared between the packing and nonpacking groups. Results: Synechia was lower in the packing group (23.5% versus 24.4%) but it was not statistically significant (P = 0.93). There were also no significant differences in the granuloma and bleeding complications between the 2 groups (respectively, P = 0.72, P = 0.08). The success rates of anatomical and functional reached 88% in the packing group compared with 82.9%, and 75.6% in the nonpacking group (respectively, P = 0.74, P = 0.76). Conclusions: The present study findings suggest that both groups have no superiorities over each other in the surgical outcomes after the EnDCR. However, further randomized studies are recommended before the generalization can be made.
Serum Mitochondrial Quality Control Related Biomarker Levels are Associated with Organ Dysfunction in Septic Patients

Supplemental Digital Content is available in the text ABSTRACT Background: To investigate the feasibility and the value of using mitochondrial quality control (MQC)-related proteins as biomarkers in septic patients. Methods: The enrolled subjects were divided into four groups: healthy control group (n = 30), intensive care unit (ICU) control group (n = 62), septic nonshock group (n = 40), and septic shock group (n = 94). Serum levels of peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α), fission protein 1 (Fis1), mitofusin2 (Mfn2), and Parkin were measured by enzyme-linked immunosorbent assay at the time of enrollment for all groups. Clinical parameters and laboratory test results were also collected. Results: The levels of MQC-related biomarkers between any two of the four groups were significantly different (P < 0.001 for all). The serum levels of PGC-1α, Mfn2, and Parkin were lowest in healthy individuals; the levels were dramatically higher in the ICU control group compared with the others, and they decreased progressively from the septic nonshock group to the septic shock group. However, the pattern for Fis1 was inverse; the more severe the condition was, the higher the level of Fis1. Moreover, there was moderate correlation between MQC-related biomarkers and the SOFA score (PGC-1α, r = −0.662; Fis1, r = 0.609; Mfn2, r = −0.677; Parkin, r = 0.−0.674, P < 0.001 for all). Conclusions: The serum levels of PGC-1α, Fis1, Mfn2, and Parkin were significantly correlated with organ dysfunction and reflected the disease progression and severity. The dynamic surveillance of these four biomarkers could be beneficial to predict outcome and guide treatment.
Classification of white blood cells using weighted optimized deformable convolutional neural networks

Abstract Background Machine learning (ML) algorithms have been widely used in the classification of white blood cells (WBCs). However, the performance of ML algorithms still needs to be addressed for being short of gold standard data sets, and even the implementation of the proposed algorithms. Methods In this study, the method of two-module weighted optimized deformable convolutional neural networks (TWO-DCNN) was proposed for WBC classification. Our algorithm is characterized as two-module transfer learning and deformable convolutional (DC) layers for the betterment of robustness. To validate the performance, our method was compared with classical MLs of VGG16, VGG19, Inception-V3, ResNet-50, support vector machine (SVM), multilayer perceptron (MLP), decision tree (DT) and random forest (RF) on our undisclosed WBC data set and public BCCD data set. Results TWO-DCNN achieved the best performance with the precisions (PREs) of 95.7%, 94.5% and 91.6%, recalls (RECs) of 95.7%, 94.5% and 91.6%, F1-scores (F1s) of 95.7%, 94.5% and 91.6%, area under curves (AUCs) of 0.98, 0.97 and 0.95 for low-resolution and noisy undisclosed data sets, BCCD data set, respectively. Conclusions With accurate feature extraction and optimized network weights, the proposed TWO-DCNN showed the best performance in WBC classification for low-resolution and noisy data sets. It could be used as an alternative method for clinical applications.
Prognostic Value of 18F–FDG–PET Parameters in Patients with Small Cell Lung Cancer: A Meta-Analysis and Review of Current Literature

Many studies have suggested a prognostic value of one or several positron emission tomography (PET) parameters in patients with small cell lung cancer (SCLC). However, studies are often small, and there is a considerable interstudy disagreement about which PET parameters have a prognostic value. The objective of this study was to perform a review and meta-analysis to identify the most promising PET parameter for prognostication. PubMed®, Cochrane, and Embase® were searched for papers addressing the prognostic value of any PET parameter at any treatment phase with any endpoint in patients with SCLC. Pooled hazard ratios (HRs) were calculated by a random effects model for the prognostic value of the baseline maximum standardized uptake value (SUVmax) and metabolic tumor volume (MTV). The qualitative analysis included 38 studies, of these, 19 studies were included in the meta-analyses. The pooled results showed that high baseline MTV was prognostic for overall survival (OS) (HR: 2.83 (95% confidence interval [CI]: 2.00–4.01) and progression-free survival (PFS) (HR: 3.11 (95% CI: 1.99–4.90)). The prognostic value of SUVmax was less pronounced (OS: HR: 1.50 (95% CI: 1.17–1.91); PFS: HR: 1.24 (95% CI: 0.94–1.63)). Baseline MTV is a strong prognosticator for OS and PFS in patients with SCLC. MTV has a prognostic value superior to those of other PET parameters, but whether MTV is superior to other prognosticators of tumor burden needs further investigation.
Time spent with viral load≤200 copies/mL in a cohort of people with HIV seen for care in Italy during the U=U prevention campaign era

Objective: Zero risk of linked HIV transmission in sero-discordant couples when the HIV-infected partner had viral load (VL) <200 copies/mL (‘U status’) was found in observational studies. We aimed at estimating the proportion of time in which ‘U status’ was maintained and identifying factors associated with the risk of losing it. Design : Observational cohort study. Methods: We included participants in the ICONA cohort who had reached an established ‘U status’ (VL≤200 copies/mL for >6 months) as of December 2010. The outcome was the number of person-days of follow up (PDFU) above a VL>200 copies/ml, relative to the total number of PDFU observed. A logistic regression model was used to identify factors independently associated with the risk of losing ‘U status’. Results: 8,241 persons living with HIV were included in the analysis who contributed 12,670,888 PDFU. Of these, 1,648 (20%) were female, 768 (9%) were people who inject drugs (PWID), and 2,066 (25%) were foreing-born. The median of VL measurements was 9 (IQR: 4-15). Overall, only 3.1% of PDFU were observed when VL was >200 copies/mL. The proportion of PDFU with VL>200 cp/ml was higher than average in females (5.3%), unemployed (5.4%), PWID (4.7%), and in people with>3 previous virologic failures (6.3%). These variables were significant predictors of losing ‘U status’ in the multivariable logistic regression. Conclusions : Our results reinforce the validity of the U=U message in real-world setting. However, we identified subsets of our study population at higher risk of losing the ‘U status’ for whom additional efforts are needed.
Analyzing Femorotibial Cartilage Thickness Using Anatomically Standardized Maps: Reproducibility and Reference Data

Alterations in cartilage thickness (CTh) are a hallmark of knee osteoarthritis, which remain difficult to characterize at high resolution, even with modern magnetic resonance imaging (MRI), due to a paucity of standardization tools. This study aimed to assess a computational anatomy method producing standardized two-dimensional femorotibial CTh maps. The method was assessed with twenty knees, processed following three common experimental scenarios. Cartilage thickness maps were obtained for the femorotibial cartilages by reconstructing bone and cartilage mesh models in tree-dimension, calculating three-dimensional CTh maps, and anatomically standardizing the maps. The intra-operator accuracy (median (interquartile range, IQR) of −0.006 (0.045) mm), precision (0.152 (0.070) mm), entropy (7.02 (0.71) and agreement (0.975 (0.020))) results suggested that the method is adequate to capture the spatial variations in CTh and compare knees at varying osteoarthritis stages. The lower inter-operator precision (0.496 (0.132) mm) and agreement (0.808 (0.108)) indicate a possible loss of sensitivity to detect differences in a setting with multiple operators. The results confirmed the promising potential of anatomically standardized maps, with the lower inter-operator reproducibility stressing the need to coordinate operators. This study also provided essential reference data and indications for future research using CTh maps.
The Natural History of Parapharyngeal Solitary Fibrous Tumor/Hemangiopericytoma: A Case Report

Solitary fibrous tumor/hemangiopericytoma (SFT/HPC) is extremely rare, and most of them are immediately treated for radical resection. However, the information concerning its natural history remains unclear. In this report, we presented a patient with parapharyngeal SFT/HPC, who was not immediately treated with surgical resection at first diagnosis. After approximately 3 years, the tumor volume doubling time (TVDT) and specific growth rate (SGR) could be measured through 3 serial magnetic resonance imagings. The TVDTs in the early and late pretreatment stages were 350 and 180 days, respectively, while the SGRs were 0.002 and 0.003, respectively. The growth rate of this disease entity is generally slow and may accelerate in the disease process.