Miracle-dz/UniFAR-FTUs huggingface dataset:
Multimodal analgesia protocol for pain management after total knee arthroplasty: comparison of three different regional analgesic techniques

Objectives: To evaluate three different analgesic techniques, continuous epidural analgesia (EA), continuous intra-articular (IA) infusion analgesia and continuous femoral nerve block (FNB) in postoperative pain management, length of hospital stay (LOS), and time of patient mobilization after total knee arthroplasty (TKA). Methods: Seventy-two patients undergoing TKA were randomly allocated into three groups according to the analgesic technique used for postoperative pain management. Group EA patients received epidural analgesia (control group), group IA received intra-articular infusion and group FNB received femoral nerve block. Results: Upon analyzing the Numerical Rating Scale (NRS) scores at rest, at passive and active movement, up to 3 days postoperatively, we observed no statistically significant differences at any time point among the three groups. Similarly, no association among these analgesic techniques (EA, IA, FNB) was revealed regarding LOS. However, significant differences emerged concerning the time of mobilization. Patients who received IA achieved earlier mobilization compared to FNB and EA. Conclusions: Both IA and FNB generate similar analgesic effect with EA for postoperative pain management after TKA. However, IA appears to be significantly more effective in early mobilization compared to EA and FNB. Finally, no clinically important differences could be detected regarding LOS among the techniques studied.
Knowledge, Attitude and Practice of Health Care Professionals towards Antimicrobial Resistance and its Stewardship at Tertiary Care Teaching Hospital

Knowledge, Attitude and Practice of Health Care Professionals towards Antimicrobial Resistance and its Stewardship at Tertiary Care Teaching Hospital Laxmi Shrestha1 *, Sabitri Pokhrel2, Amit Kumar Shrivastava1, Buddhi Raj Pokhrel3, Bishal Joshi4, Pradip Chhetri5 Lecturer, Department of Pharmacology,Lecturer, Department of Biochemistry, Lecturer, Department of Physiology, Lecturer, Department of Community Medicine, Universal College of Medical Sciences, Rupandehi, Bhairahawa, Nepal, 32900 Swarnim Pharma, Bharatpur, Chitwan, Nepal Corresponding author: Laxmi Shrestha*Email/contact: drshresthalaxmi@gmail.com; 9804263379 ABSTRACT Background: Irrational antibiotic use leads to resistance, a serious problem which is increasing tremendously and requires urgent response. The goal of this study is to evaluate knowledge, attitude, and practice of health care professionals (HCPs) regarding antimicrobial resistance (AMR) and its stewardship. Methods: This questionnaire based prospective cross-sectional study was conducted in 216 HCPs of Universal College of Medical Sciences (UCMS). Chi-square analysis was used to see the association of knowledge, attitude, and practice (KAP) with other demographic variables. Pearson correlation was done to analyze the correlation between knowledge and attitude, knowledge and practice, and attitude and practice. Results: Among all participants, 33% had good knowledge, majority of them (78.2%) had positive attitude and 43.5% had good practice related to antimicrobial resistance and its stewardship. There was no significant correlation between knowledge and practice, as well as between practice and attitude. However, a weak positive correlation was found between knowledge and attitude (r=0.186; p=0.006). Conclusion: The majority of health care professionals showed a positive attitude towards antibiotic resistance and its stewardship. However, in spite of positive attitude of HCPs, the level of knowledge and practice were found to be poor.
CAN CATCH CROPS BE AN IMPORTANT FACTOR IN CARBON DIOXIDE SEQUESTRATION?

The sequestration of carbon dioxide in the biomass of plants, especially the ones which can be cultivated as catch crops is described. It has been shown that the cultivation of catch crops may play an important role in the mitigation of CO2 emissions. A study on the importance of catch crops (in relation to the main crop) in carbon dioxide sequestration was conducted over the period of 2016-2018 under the soil and climatic conditions of the central Lublin region, Poland. Subsequently, ploughed-in catch crop biomass is a kind of ‘soil CO2 bank’. It was proven that in the case of successful catch crops one can expect carbon dioxide sequestration by these crop cultures to be at a level from 4 to 6 tons CO2 ha ·yr. The quantity of CO2 absorbed from the atmosphere by a catch crop is directly proportional to biomass yield produced by it. The following species, which are resilient to adverse weather conditions during seeding and initial plant growth, proved to be particularly useful in carbon dioxide sequestration by catch crops: white mustard, tansy phacelia, winter rye, winter wheat + winter vetch mixture. Catch crops also positively affect the amount of soil organic C compared to soils where they are not grown. Based on the obtained study results, it can be tentatively stated that catch crops are an important factor in carbon dioxide sequestration in broadly understood agricultural activity. It is advisable to promote catch crops on a wide scale due to relatively small costs of such crops compared to the benefits arising from them (phytosanitary effects on soil, CO2 sequestration, and soil carbon storage). It is however necessary to conduct further research in this area in order to determine the suitability of specific catch crop species for CO2 sequestration in various climatic and soil zones.
Pressure drop and heat transfer in an isothermal channel with impinging flow

The performance of air-cooled plate-fin heat sinks in impinging flow differs significantly from that of similar heat sinks in parallel flow. A numerical experiment and analytical scaling has been carried out to determine the pressure drop and thermal performance of single isothermal channels with variable-width impinging flow. The flow enters the channel normal to the heat sink base. The pressure drop and thermal performance of the flow in this configuration are particularly important for analyzing plate-fin heat sinks for which axial fans supply the flow, since the fan flow rate varies with the static pressure. The results of the numerical experiment and scaling are combined into dimensionless correlations for pressure loss coefficient and channel average Nusselt number. These correlations may then be used to predict the thermal performance of the heat sink.
INCIDENCE OF REPEAT BREEDING SYNDROME IN HOLSTEIN FRIESIAN CATTLE

Repeat breeding syndrome could be described as a cow's failure to conceive after three or more than three inseminations in the absence of any clinically relevant abnormality. In order to determine the incidence of repeat breeding, a retrospective study which included data from 682 Holstein Friesian cows within two dairy herds across Belgium were collected during two consecutive years. Thus, the repeat breeding overall incidence in dairy cattle was 18.1% (124 cows). The highest incidence of repeat breeding syndrome was recorded during spring season (5.6%, n=38) the lowest incidence being during winter season (2.9%, n=20). Regarding postpartum disorders, our study revealed that in cows with endometritis, metritis, milk fever and retained fetal membranes, the incidence of repeat breeding was higher than in cows that became pregnant within first three artificial inseminations (were considered to have normal fertility). According to parity number, the highest incidence of repeat breeding syndrome was recorded during 1st (3.9% n = 27) and 5th (4.1%, n = 28) parities, the lowest incidence being recorded during 6th (1.9%, n = 13) and 7th (0.29%, n = 2). Also, in cows with repeat breeding, the reproductive indices were negatively modified, triggering thus a poor reproductive performance. In conclusion, our results show that repeat breeding syndrome involves a various number of factors, such as postpartum disorders as well as extrinsic factors.
Crystal structure of pyridine-2-carbaldehyde thiosemicarbazonium chloride hydrate, [C7H9N4S]Cl · H2O

C7H11ClN4OS, monoclinic, P21/n (no. 14), a = 4.9525(9) Å, b = 13.859(2) Å, c = 15.799(3) Å, * = 98.011(2)°, V = 1073.8 Å, Z = 4, Rgt(F) = 0.038, wRref(F ) = 0.096, T = 296 K.
Relationship Between Polycystic Ovarian Morphology and Ectopic Pregnancy

Background: The purpose of the current study was to investigate the presence of polycystic ovarian morphology (PCOM) in patients with ectopic pregnancy (EP) and to find out the value of sonographic appearance of ovaries on the earlier diagnosis of EP. Methods: In the current case-control study, thirty five patients with EP were recruited to evaluate ovarian sonographic morphology whereas 35 gestational age-matched women with healthy intrauterine pregnancy (IUP) were the controls. After ovarian sonography, ultrasound images were analyzed offline for ovarian area, ovarian volume, follicle number per cross section, and follicle distribution pattern. A questionnaire about the presence of hirsutism and menstrual irregularity prepared as well. Student’s t-test or Mann-Whitney U test were used to compare continuous variables between 2 groups and categorical data were evaluated by using Chi-square or Fisher’s exact test, where appropriate. Multiple logistic regression was used to find out the risk factors for EP. Results: Mean gravidity and parity were significantly higher in the EP group compared to IUP group (p<0.05). PCOM was found to be significantly higher in the study group (51.4% vs. 20%, p=0.006). Logistic regression analysis showed that multiparity (OR=8.635; 95% CI, 1.653–45.104) and PCOM image on ultrasound (OR=19.081; 95% CI, 1.139–319.560) were found to be significantly associated with EP. Conclusion: PCOM is more prevalent among women diagnosed with EP. This study demonstrates that PCOM assessed by transvaginal ultrasound may reflect EP in women with EP suspicion and may therefore serve as a clinical marker to assess EP.
A Basic Framework for Explanations in Argumentation

We discuss explanations for formal (abstract and structured) argumentation—the question of whether and why a certain argument or claim can be accepted (or not) under various extension-based semantics. We introduce a flexible framework, which can act as the basis for many different types of explanations. For example, we can have simple or comprehensive explanations in terms of arguments for or against a claim, arguments that (indirectly) defend a claim, the evidence (knowledge base) that supports or is incompatible with a claim, and so on. We show how different types of explanations can be captured in our basic framework, discuss a real-life application and formally compare our framework to existing work.
The Effect of Pay Schemes and Long-Term Orientation on Managers’ CSR Overinvestment Ethical Judgments

This study aims to shed light on the role pay schemes and individual factors (i.e. long-term orientation) play in influencing managers’ ethical judgments on corporate social responsibility (CSR) overinvestment. Built on an egocentric concept, the study predicts that managers employed under different pay schemes and with different levels of long-term orientation will make different ethical judgments on such overinvestment. It employs an experimental approach, in which the pay scheme variable is divided into two types: an overinvestment-inducing one, and an overinvestment-hindering one. In measuring managers’ long-term orientation, the study adopts Bearden et al.’s (2006) measurement. It finds evidence that managers on an overinvestment-hindering pay scheme are more likely to consider overinvestment in CSR to be more unethical than those employed on an overinvestment-inducing scheme. Moreover, managers who have higher long-term orientation are more likely to judge overinvestment in CSR to be unethical. However, the study finds no evidence of the interaction effect of pay schemes and long-term orientation in affecting managers’ ethical judgment on overinvestment in corporate social responsibility. JEL Classification: M410, M140, M120
Single Nucleotide Polymorphism of ADIPOQ Gene (Rs822393) Is Associated with Lipid Profile, Adiponectin Levels and Ratio of Adiponectin/Leptin ratio in Adult Obese Subjects

Objectives: Some studies in the literature indicate that ADIPOQ rs822393 polymorphism functionally regulates adiponectin levels. The aim of this study was to describe the association of rs822393 with adiponectin levels, cardiovascular risk factors, diabetes mellitus type 2 and metabolic syndrome. Patients and Methods: The study involved a population of 1004 Caucasian adult obese subjects. Anthropometric parameters, blood pressure, fasting blood glucose, C-reactive protein (CRP), insulin concentration, insulin resistance (HOMA-IR), lipid profile, adipokines levels, ratio adiponectin/leptin ratio and prevalence of MS were recorded. Genotype of ADIPOQ gene polymorphism (rs822393) was evaluated. Results: The distribution of the rs822393 polymorphism in this adult population was 62.1% (n=623) (CC), 32.1% (n=322) (CT) and 5.8% (n=59) (TT). We observed an association between the minor T allele and lower HDL cholesterol levels (CC vs. CT+TT: delta: 6.6+1.2 mg/ml;p=0.03) and lower adiponectin levels (CC vs. CT+TT: delta: 19.9+3.2 mg/ml;p=0.02). T allele carriers showed lower adiponectin/leptin ratio (CC vs. CT+TT: delta: 0.29+0.1 mg/ml;p=0.02) than non T allele carriers. Logistic regression showed that the T allele increased the risk of low HDL cholesterol (OR=2.75, 95% CI=1.87-4.02, p=0.03), after adjusting by BMI and age.
Characterization and In Vivo Efficacy of Targeted Nanoparticles for Systemic siRNA Delivery to Tumors

Systemic delivery of nucleic acid molecules is one of the major hurdles limiting the application of siRNA-based therapeutics for cancer treatment. Multifunctional nanoparticles are being investigated as systemic, nonviral nucleic acid delivery systems, and here we describe the use of cyclodextrin-containing polycations (CDP) to interact with small interfering RNA (siRNA) molecules to form nanoparticles that are approximately 60-80 nm in diameter. The modular design of these nanoparticles enables modification with PEG molecules for steric stabilization and transferrin targeting ligands for uptake by tumor cells. The nanoparticles protect the nucleic acid payload from nuclease degradation, do not aggregate at physiological salt concentrations, and cause minimal erythrocyte aggregation and complement fixation at the concentrations typically used for in vivo application. These nanoparticles are able to deliver functional siRNA molecules to metastatic and subcutaneous tumors in mice after systemic administration.
Early diagnosis and surgical management in adult intussusceptions caused by ectopic pancreas

Adult intussusception comprises of only 5% of all intussusception cases with majority occurring in children and accounts for only 1–5% cases of bowel obstruction in adults. Ectopic pancreas is an infrequent anomaly defined as pancreatic tissue that lacks anatomical or vascular communication with the normal body of the pancreas. When reported it is mostly found in the stomach and small intestines but seldom in the colon. We present a case of a 31-year-old male who presented with symptoms of an acute abdomen which was diagnosed as an intussusception of an unknown etiology on a contrast-enhanced computed tomography (CT). The patient was resuscitated and immediately operated on and underwent a right hemicolectomy and eventually an end ileostomy formation. No cause for the intussusception was apparent intra-operatively but histological examination of the resected bowel specimen demonstrated ectopic pancreas. The patient had a very short recovery time without incident which may be attributed to his age and absence of co-morbidities. He was discharged a follow-up plan to discuss the reversal. The patient went on to have reversal of his stoma after six months of the initial surgery with a very good outcome.
Fast, flexible, and comprehensive bug detection for persistent memory programs

Debugging persistent memory (PM) programs faces a fundamental tradeoff between performance overhead and bug coverage (comprehensiveness). Large performance overhead or limited bug coverage makes debugging infeasible or ineffective for PM programs. We present PMDebugger, a debugger that detects crash consistency bugs in PM programs. Unlike prior work, PMDebugger is fast, flexible and comprehensive. The design of PMDebugger is driven by a characterization that shows how three fundamental operations in PM programs (store, cache writeback and fence) typically occur in PM programs. PMDebugger uses a hierarchical design composed of PM debugging-specific data structures, operations and bug-detection algorithms (rules). We generalize nine rules to detect crash-consistency bugs for various PM persistency models. Compared with a state-of-the-art detector (XFDetector) and an industry-quality detector (Pmemcheck), PMDebugger leads to 49.3x and 3.4x speedup on average. Compared with another state-of-the-art detector (PMTest) optimized for high performance, PMDebugger achieves comparable performance (within a factor of 2), without heavily relying on programmer annotations, and detects 38 more bugs on ten applications. PMDebugger also identifies more bugs than XFDetector and Pmemcheck. PMDebugger detects 19 new bugs in a real application (memcached) and two new bugs from Intel PMDK.
Deliquescence of ammonium sulfate particles at sub‐eutectic temperatures

To better understand atmospheric aerosol phase transitions under free tropospheric conditions, the behavior of ammonium sulfate (AS) particles mounted on a silicon substrate has been investigated between 229 and 295 K. Experiments were performed in a chamber where water partial pressure and particulate infrared spectra were monitored as the temperature was lowered. Deliquescence experiments at temperatures above the eutectic (254 K) are not new, however results defining deliquescence relative humidity (DRH) at temperatures below the eutectic have been lacking. At sub‐eutectic temperatures the system is supersaturated with respect to ice, therefore both deliquescence and ice formation were possible. Within experimental error, deliquescence was observed at the thermodynamically predicted value both above and below the eutectic. The lack of a significant kinetic barrier to deliquescence implies that AS particles could form supercooled solution droplets at high relative humidities, and function as ice nuclei if these droplets homogeneously freeze.
Chapter twenty-five Mediation and Moderation

Our goal in this chapter is to provide an up-to-date and relatively comprehensive treatment of procedures for assessing mediation and moderation in socialpersonality psychology. Both of these processes enable researchers to ask questions of their data that extend the theoretical scope of inquiry beyond simply establishing some overall experimental effect or some simple relationship between two variables. That is, they both begin to enable researchers to arrive at a more comprehensive theoretical understanding of what produces an effect of interest by probing intricacies of that effect. As such, they are related but distinct analytic tools. They are related in the sense that they permit researchers to probe mechanisms underlying and limiting conditions for effects of interest. And yet, the questions they pose are fundamentally different, in ways that are often confused, and the underlying models are distinct.
Attachement of bacteria to slides submerged in sea water

Z o B e Il and AlI en (1932 and 1935) have ascertained that in the fouling of different su:bmerged surfaces, there is a sertain succession of organisms, and that the first fiImon such surfaces is laid by bacteria. The rapidity orf the creation orf the first film, L e. the swiftness of the attachment of bacteria depends on different oecological factors. The same authors have furthermore ascertained in examining the rapidity of the attachment of 74 :marine bacteriaI species under laboratoriai conditions, that only 32,87% of the ibacteria stuck to the submerged sIides. The authors have cal1ed.these species »a t t a c h eme n t b ac ter i a« and Iater on He n ri ci (1936) proposed the name of »Peri p hiti c b a c ter i a«. In connection with the preliminary works about the stu,dy of the problem of ships fouling, we have performed different experiments by immersing Bome s1ides into the sea, in ordar to get a picture a! bout the quickness of thebacterial attaohment on clean and smooth surfaces in the conditions of the Adriatic Sea. These particulars will serve to u:sas an orientation in our workabout the attachment of bacteria oncoloured surfaces submerged into sea water.
Torus actions on manifolds with positive intermediate Ricci curvature

We study closed, simply connected manifolds with positive 2nd$2^\mathrm{nd}$ ‐intermediate Ricci curvature and large symmetry rank. In odd dimensions, we show that they are spheres. In even dimensions other than 6, we show that they must have positive Euler characteristic. Under stronger assumptions on the symmetry rank, we show that such even‐dimensional manifolds must have trivial odd degree integral cohomology, and if the second Betti number is no more than 1, they are either spheres or complex projective spaces. In the process, we establish new tools for studying isometric actions on closed manifolds with positive kth$k\mathrm{th}$ ‐intermediate Ricci for values of k⩾2$k \geqslant 2$ . These tools include generalizations of the isotropy rank lemma, symmetry rank bound, and connectedness principle from the setting of positive sectional curvature.
Non-directed polymers in heavy-tail random environment in dimension d≥2

In this article we study a non-directed polymer model in dimension d ≥ 2: we consider a simple symmetric random walk on Z which interacts with a random environment, represented by i.i. d. random variables (ωx)x∈Zd . The model consists in modifying the law of the random walk up to time (or length) N by the exponential of ∑ x∈RN β(ωx−h) where RN is the range of the walk, i.e. the set of visited sites up to time N , and β ≥ 0, h ∈ R are two parameters. We study the behavior of the model in a weak-coupling regime, that is taking β := βN vanishing as the length N goes to infinity, and in the case where the random variables ω have a heavy tail with exponent α ∈ (0, d). We are able to obtain precisely the behavior of polymer trajectories under all possible weak-coupling regimes βN = β̂N −γ with γ ≥ 0: we find the correct transversal fluctuation exponent ξ for the polymer (it depends on α and γ) and we give the limiting distribution of the rescaled log-partition function. This extends existing works to the non-directed case and to higher dimensions. 2010 Mathematics Subject Classification: 82D60, 60K37, 60G70