Miracle-dz/UniFAR-FTUs huggingface dataset:
Demonstration of the Early Cardiac Bioavailability of a Non-Specific Cell-Targeted Peptide Using Radionuclide-Based Imaging In Vivo

The cardiac bioavailability of peptide drugs that inhibit harmful intracellular protein–protein interactions in cardiovascular diseases remains a challenging task in drug development. This study investigates whether a non-specific cell-targeted peptide drug is available in a timely manner at its intended biological destination, the heart, using a combined stepwise nuclear molecular imaging approach. An octapeptide (heart8P) was covalently coupled with the trans-activator of transcription (TAT) protein transduction domain residues 48–59 of human immunodeficiency virus-1 (TAT-heart8P) for efficient internalization into mammalian cells. The pharmacokinetics of TAT-heart8P were evaluated in dogs and rats. The cellular internalization of TAT-heart8P-Cy(5.5) was examined on cardiomyocytes. The real-time cardiac delivery of 68Ga-NODAGA-TAT-heart8P was tested in mice under physiological and pathological conditions. Pharmacokinetic studies of TAT-heart8P in dogs and rats revealed a fast blood clearance, high tissue distribution, and high extraction by the liver. TAT-heart-8P-Cy(5.5) was rapidly internalized in mouse and human cardiomyocytes. Correspondingly, organ uptake of hydrophilic 68Ga-NODAGA-TAT-heart8P occurred rapidly after injection with an initial cardiac bioavailability already 10 min post-injection. The saturable cardiac uptake was revailed by the pre-injection of the unlabeled compound. The cardiac uptake of 68Ga-NODAGA-TAT-heart8P did not change in a model of cell membrane toxicity. This study provides a sequential stepwise workflow to evaluate the cardiac delivery of a hydrophilic, non-specific cell-targeting peptide. 68Ga-NODAGA-TAT-heart8P showed rapid accumulation in the target tissue early after injection. The implementation of PET/CT radionuclide-based imaging methodology as a means to assess effective and temporal cardiac uptake represents a useful and critical application in drug development and pharmacological research and can be extended to the evaluation of comparable drug candidates.
ATLASGAL - Complete compact source catalogue: 280 ◦ < < 60 ◦ (Research Note)

Context. The APEX Telescope Large Area Survey of the Galaxy (ATLASGAL) is the largest and most sensitive systematic survey of the inner Galactic plane in the submillimetre wavelength regime. The observations were carried out with the Large APEX Bolometer Camera (LABOCA), an array of 295 bolometers observing at 870 μm (345 GHz). Aims. In this research note we present the compact source catalogue for the 280 ◦ <� < 330 ◦ and 21 ◦ <� < 60 ◦ regions of this survey. Methods. The construction of this catalogue was made with the source extraction routine SExtractor using the same input parameters and procedures as used to analyse the inner Galaxy region presented in an earlier publication (i.e., 330 ◦ <�< 21 ◦ ). Results. We have identified 3523 compact sources and present a catalogue of their properties. When combined with the regions already published, this provides a comprehensive and unbiased database of ∼10 163 massive, dense clumps located across the inner Galaxy.
Increasing rate of road traffic accidents in Sub Saharan Africa, an issue of negligence or carelessness? Case study, Cameroon

Objective: Road traffic injuries (RTIs) have over the years been on the rise with most casualties coming from the African region, even though they possess and utilize less cars than the developed countries. The purpose of this paper was to highlight the government's and civilians' negligence and carelessness in reducing the incidence of RTIs in Africa, using Cameroon as a case study. Methods of Review: This paper examined various literature searches from Science Direct, PubMed, World Health Organization official reports, Ministry of Public Health Cameroon reports, United Nations Population Fund (UNFPA), Centre for Disease Control and Prevention (CDC), and Scopus. Results: The burden of RTIs is not only felt medically but economically as most victims are often left to cater for their injuries from their personal expenses with little or no government assistance. Although there is a significant lack of data on the exact number of deaths related to road traffic accidents due to poor reporting systems, a variety of factors account for this including; unequitable resource distribution, lack of well-trained paramedics, mismanaged funds, and improper, control, and management of existing road traffic policies. Conclusion: The steady rise in RTIs in Cameroon has cut short the lives of most young people, adversely affected Quality of Life, increased economic burden, we are confident that the best approach to reducing the fatality rate from road accidents is by reviewing and amending policies governing transport systems in Cameroon.
Observations of record cold cloud-top temperatures in Tropical Cyclone Hilda (1990)

Abstract A detailed analysis is made of the development of a region of cold cloud-top temperatures in Tropical Cyclone Hilda (1990) in the Coral Sea off eastern Australia. Observed temperatures of approximately 173 K (−100°C) from two independent satellite sources indicate that the convective turrets penetrated well into the stratosphere to an estimated height of around 19.2 km. The analytical parcel model of Schlesinger is used, together with available observations from the cyclone vicinity, to estimate the convective updrafts required to produce the observed stratosphere penetration. Under realistic assumptions of entrainment and hydrometeor drag, an updraft speed of between 15 and 38 m s−1 at tropopause level is required to provide the observed stratospheric penetration. Independent calculations using observed anvil expansion and environmental CAPE (convective available potential energy) support these updraft findings.
ConvGRU-CNN: Spatiotemporal Deep Learning for Real-World Anomaly Detection in Video Surveillance System

Video surveillance for real-world anomaly detection and prevention using deep learning is an important and difficult research area. It is imperative to detect and prevent anomalies to develop a nonviolent society. Real-world video surveillance cameras automate the detection of anomaly activities and enable the law enforcement systems for taking steps toward public safety. However, a human-monitored surveillance system is vulnerable to oversight anomaly activity. In this paper, an automated deep learning model is proposed in order to detect and prevent anomaly activities. The real-world video surveillance system is designed by implementing the ResNet-50, a Convolutional Neural Network (CNN) model, to extract the high-level features from input streams whereas temporal features are extracted by the Convolutional GRU (ConvGRU) from the ResNet-50 extracted features in the time-series dataset. The proposed deep learning video surveillance model (named ConvGRU-CNN) can efficiently detect anomaly activities. The UCF-Crime dataset is used to evaluate the proposed deep learning model. We classified normal and abnormal activities, thereby showing the ability of ConvGRU-CNN to find a correct category for each abnormal activity. With the UCF-Crime dataset for the video surveillance-based anomaly detection, ConvGRU-CNN achieved 82.22% accuracy. In addition, the proposed model outperformed the related deep learning models.
Beneficial Microorganisms Affect Soil Microbiological Activity and Corn Yield under Deficit Irrigation

Water scarcity is one of the main factors that decrease the growth and productivity of corn, since it negatively affects gas exchange and the general metabolism of the crop. The use of beneficial microorganisms (BM) has been considered a potential attenuator of water stress. This study aimed to evaluate the effect of BM and water deficit on growth, gas exchange, grain yield, and soil microbial activity. A field experiment was carried out, in which the treatments were composed of a 2 × 4 factorial scheme, corresponding to two irrigation levels (100% of ETc and 50% of ETc) and to four treatments (T) referring to the soil inoculation with BM (C: control; T1: Bacillus amyloliquefaciens + Azospirillum brasiliense; T2: B. subtilis; and T3: A. brasiliense). The evaluations were carried out in the flowering phase (plant growth, gas exchange, and foliar nitrogen content) and at the end of the plant cycle (grains yield, mineral nitrogen, and microbiological activity). The 50% reduction in irrigation depth severely restricted corn growth and gas exchange and decreased the grain yield by 38%. The water deficit increased the protein content in the grains and the concentration of mineral nitrogen in the soil when the plants were inoculated with BM. Under water stress, inoculation with BM increased corn productivity by 35% and increased soil microbial activity. The inoculation of plants with BM, either in combination (Bacillus amyloliquefaciens + A. brasiliense) or alone (B. subtilis), attenuated the adverse effects of water deficit in maize.
Analysis of distributions reveals real differences on dichotic listening scores between left- and right-handers

Abstract About 95% of right-handers and 70% of left-handers have a left-hemispheric specialization for language. Dichotic listening is often used as an indirect measure of this language asymmetry. However, while it reliably produces a right-ear advantage (REA), corresponding to the left-hemispheric specialization of language, it paradoxically often fails to obtain statistical evidence of mean differences between left- and right-handers. We hypothesized that non-normality of the underlying distributions might be in part responsible for the similarities in means. Here, we compare the mean ear advantage scores, and also contrast the distributions at multiple quantiles, in two large independent samples (Ns = 1,358 and 1,042) of right-handers and left-handers. Right-handers had an increased mean REA, and a larger proportion had an REA than in the left-handers. We also found that more left-handers are represented in the left-eared end of the distribution. These data suggest that subtle shifts in the distributions of DL scores for right- and left-handers may be at least partially responsible for the unreliability of significantly reduced mean REA in left-handers.
Analysis of the Propagation of Light Along an Array of Nanorods Using the Generalized Multipole Techniques

In this work, with the help of the generalized multipole technique and an efficient iterative procedure, the complex propagation constant of a plasmonic waveguide comprised of an infinite array of silver nanorods is computed. Our analysis takes into account metallic losses reported elsewhere using experimental methods. A finite array of only eight silver nanorods is also investigated here. The finite array is investigated for its capability of guiding light waves when excited by a plane wave at the specific wavelengths of the guided modes of the corresponding infinite array.
Comparison of Long-term Preventive Effects of Dual Antiplatelet Therapy vs. Monotherapy in High Cardiovascular Risk Patients After Myocardial Infarction with Nonobstructive Coronary Arteries (MINOCA)

Myocardial infarction with nonobstructive coronary arteries (MINOCA) has similar outcomes to patients with acute MI with obstructive coronary disease for up to 1 year. According to existing evidence, dual antiplatelet therapy (DAPT) was not significantly better than aspirin alone in lowering 1-year MACCEs in different cardiovascular risk patients with non-obstructive coronary artery disease.
Resonant dynamics of three-dimensional skyrmionic textures in thin film multilayers

Skyrmions are topological magnetic solitons that exhibit a rich variety of dynamics, such as breathing and gyration, which can involve collective behavior in arrangements like skyrmion lattices. However, such localized excitations typically lie in the gap of the spin wave spectrum and do not couple to propagating modes. By combining magnetic force microscopy, broadband ferromagnetic resonance, and micromagnetics simulations, we show that in thin-film multilayers of [Pt/FeCoB/AlOx]20 a high-frequency (>12 GHz) mode accompanies the skyrmion lattice phase, which involves the coherent precession of the skyrmion cores that results in the generation of 50–80 nm wavelength spin waves flowing into the uniformly magnetized background. This observation is made possible by a Gilbert damping constant of ∼0.02, which is nearly an order of magnitude lower than in similar ultrathin materials. The simulations also reveal a complex three-dimensional spin structure of the skyrmion cores, which plays a key role for spin wave generation.
Synthesis of Tilapia Feed From a Mixture of Tarum Leaves (Indigosfera sp) and Fermented Shrimp Waste by EM-4 Probiotics

Feed is the most important thing in doing a tilapia fish farming. In a feed required appropriate and balanced nutritional content so that fish growth becomes faster. Shrimp waste and tarum leaves are an alternative raw material for the manufacture of tilapia feed because they have a fairly high protein content. The purpose of this study was to examine the comparative effect of adding the percentage of tarum leaf meal and EM-4 fermented shrimp waste on water content, ash content, protein content, fat content, and crude fiber content of feed. The research method used is using the EM-4 fermentation process on shrimp waste. The variations carried out were the concentration of the addition of EM-4 (14,16,18,20, and 22 ml) and the percentage of addition of Wet Shrimp Waste (WSW) and Tarum Leaf Powder (TLP) (90%WSW + 10%TLP, 80%WSW + 20%TLP, 70%WSW + 30%TLP, 60%WSP + 40%TLP, and 50%WSW + 50%TLP). The results showed that the addition of fermented WSW EM-4 and TLP had a significant effect on the protein, fat and crude fiber content, while the water and ash content did not have a significant effect. The best tilapia feed formulation results were obtained at a ratio of 60% WSW and 40% TLP using 18 ml of EM-4 with the results obtained for water, ash, protein, fat and crude fiber content each of 7.09%. ; 12.59%; 29.98%; 7.45%; and 3.49%.
A Review of Inactivated COVID-19 Vaccine Development in China: Focusing on Safety and Efficacy in Special Populations

The coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been widespread globally, and vaccination is critical for preventing further spread or resurgence of the outbreak. Inactivated vaccines made from whole inactivated SARS-CoV-2 virus particles generated in Vero cells are currently the most widely used COVID-19 vaccines, with China being the largest producer of inactivated vaccines. As a result, the focus of this review is on inactivated vaccines, with a multidimensional analysis of the development process, platforms, safety, and efficacy in special populations. Overall, inactivated vaccines are a safe option, and we hope that the review will serve as a foundation for further development of COVID-19 vaccines, thus strengthening the defense against the pandemic caused by SARS-CoV-2.
Prediction of Supersonic Jet Noise

Noise radiated from a supersonic jet is computed using the Parabolized Stability Equations (PSE) method. The evolution of the instability waves inside the jet is computed using the PSE method and the noise radiated to the far field from these waves is calculated by solving the wave equation using the Fourier transform method. We performed the computations for a cold supersonic jet of Mach number 2.1 which is excited by disturbances with Strouhal numbers St=. 2 and . 4 and the azimuthal wavenumber m=l. Good agreement in the sound pressure level are observed between the computed and the measured (Troutt and McLaughlin 1980) results. In this work we computed the noise radiated from supersonic turbulent jets using the PSE (Parabolized Stability Equations) method. Jet noise can be divided into three categories: (1) shock-induced screech tone noise; (2) shock-induced broad band noise; and (3) turbulent mixing noise. The screech tone appears in an imperfectly expanded jet as discrete band in the front part of the jet. The screech tone phenomena is very complex and it is believed that the toroidal and helical vortices which shed at the lip of the nozzle interact with the shocks when they propagate downstream and makes the shock to oscillate and this radiates sound in the upstream direction at discrete frequency. In an imperfectly expanded jet, the shockcells formed by the oblique shocks or the expansion fans generated at nozzle lip interact with the large scale turbulence and generate broad band noise. The dominant part of the broad band shock-associated noise is comprised of a spectral peak with a relatively narrow half-width. Turbulent mixing noise is the noise component which is contributed from the largescale and small scale turbulence in the jet. For a perfectly expanded supersonic jet, the noise is completely generated by the turbulence in the jet and the predominant part of the noise is radiated in the downstream direction in the range between 25^5°. It is observed that at low Reynolds numbers the noise is radiated at a discrete frequency which is closer to the most unstable instability wave for that jet. At moderate and high Reynolds numbers there is discernible peak but they become broad band. These similarities between the noise generated from the high and low Reynolds number jets imply that the noise generation mechanisms in supersonic jets are same at different Reynolds numbers. Several experiments were performed to identify these mechanisms ( McLaughlin et al. 1975, 1977, Morrision and McLaughlin 1979, 1980, Troutt and McLaughlin 1982, Seiner et al. 1993) and it is concluded that the dominant part of the turbulent mixing noise of high Reynolds number supersonic jets is generated by the large-scale coherent structures. It is also concluded that these
QUINTIC B-SPLINE COLLOCATION METHOD FOR NUMERICAL SOLUTION OF THE EXTENDED FISHER-KOLMOGOROV EQUATION

In this paper, numerical solutions of the extended Fisher-Kolmogorov equation are obtained by using the quintic B-spline collocation scheme. The scheme is based on the Crank–Nicolson formulation for time integration and quintic B-spline functions for space integration. The accuracy of the proposed method is demonstrated by three test problems. The scheme has second order convergence.
Developing Undergraduate Learning Assistants’ Skills in Guiding Science Learning

This concurrent triangulation mixed method design study describes the influence of a science education seminar (SES) on the learning assistants’ (LAs) perceptions of their roles in the classroom. The SES was developed to train undergraduate students as LAs at a Southern liberal arts college in the USA. The focus of the seminar was teaching the LAs how to guide students through the learning process. Using the LAs perception survey, a pre and post-survey was administered to a conveniently sampled nine LAs to observe changes in their perceptions of their role. An interview was given to eleven LAs at the end of the seminar to investigate their perception of the seminar and any changes that had occurred in their perceptions of their role as LAs. A test of the significance of the quantitative data was done using the Kruskal–Wallis Chi-square and the qualitative data were analyzed using Atlas software. The pre- and post-survey results indicated that the LAs’ perceptions about their roles changed during the semester. During an interview conducted at the end of the seminar, LAs indicated that their views on how to approach students’ problems had changed mainly due to the seminar. The interview also showed that the LAs felt that the seminar was valuable because it changed the way they viewed themselves in their role. Results from this study inform colleges of the importance of training LAs.
The Association Between Improvement of Stereoacuity and Suppression in the Treatment of Anisometropic Amblyopia

Purpose To investigate the association between stereoacuity and suppression during occlusion therapy for patients with anisometropic amblyopia. Design Retrospective study. Patients and Methods This study included 19 patients with hyperopic anisometropic amblyopia who underwent occlusion therapy. The mean age of the patients was 5.5 ± 1.4 years. The participants were evaluated for improvement in stereoacuity and suppression before beginning occlusion therapy, when the highest amblyopic visual acuity (VA) was achieved, during tapering, at the end of occlusion therapy, and at the final visit. Stereoacuity was evaluated using the TNO test or JACO stereo test. The presence of suppression was evaluated using circle No. 1 of the Stereo Fly Test or JACO results as the optotype. Results Of the 19 patients, 13 (68.4%) had suppression before occlusion, eight (42.1%) when the highest VA was achieved, five (26.3%) during tapering, and none at the final visit. Of the 13 patients with suppression before occlusion, 10 (76.9%) showed further improvement in stereoacuity when suppression disappeared, and nine had foveal stereopsis of 60 arcseconds. A significant association was confirmed between foveal stereopsis and suppression when the highest VA was achieved and during the tapering period (P<0.05, Fisher’s exact test). Conclusion Suppression was observed even when the VA in amblyopic eyes reached the highest score. By gradually decreasing the duration of occlusion, suppression was eliminated, leading to the acquisition of foveal stereopsis.
Extraction and Characterization of Silica from Empty Palm Fruit Bunch (EPFB) Ash

Recently, there has been so much interest in using biomass waste for bio-based products. Nigeria is one of the countries with an extensive availability of palm biomass. During palm oil production, an empty palm fruit bunch (biomass) is formed, and a lot of ash is generated. This study aimed to extract and characterize silica from empty palm fruit bunch (EPFB) ash using the thermochemical method. The results show that EPFB ash contains a large amount of biogenic silica in its amorphous form. It could be extracted for further use via calcination at different temperatures and compared effectively to other biomass materials, such as rice husk ash, sugarcane bagasse, and cassava periderm. The extracted silica was characterized using XRF, XRD, TGA, SEM, and FTIR, revealing the highest silica concentration of 49.94% obtained at a temperature of 800 °C. The XRF analysis showed 99.44 wt. % pure silica, while the XRD spectrum showed that the silica in EPFB is inherently amorphous. As is evident from the study, silica obtained from EPFB ash is a potential source of silica and it is comparable to the commercial silica. Thus, it is potentially usable as a support for catalysts, in the development of zeolite-based catalysts and as an adsorbent.
A Novel method to compress still Images using Golomb Code (GC) in JPEG2000

†Summary JPEG2000 is a widely used standard image compression method. It makes use of EBCOT to compress the co-efficients of the Discrete Wavelet co-efficients. The JPEG2000’s algorithm is based on Discrete Wavelet Transform(DWT) and the Embedded Block Coding with Optimal Truncation (EBCOT). Golomb codes, a code in which no codeword is also a prefix of some other codeword. We propose that the EBCOT can be replaced by Golomb code which gives better result.