Miracle-dz/UniFAR-FTUs huggingface dataset:
Stable Gastric Pentadecapeptide BPC 157 as Useful Cytoprotective Peptide Therapy in the Heart Disturbances, Myocardial Infarction, Heart Failure, Pulmonary Hypertension, Arrhythmias, and Thrombosis Presentation

In heart disturbances, stable gastric pentadecapeptide BPC 157 especial therapy effects combine the therapy of myocardial infarction, heart failure, pulmonary hypertension arrhythmias, and thrombosis prevention and reversal. The shared therapy effect occurred as part of its even larger cytoprotection (cardioprotection) therapy effect (direct epithelial cell protection; direct endothelium cell protection) that BPC 157 exerts as a novel cytoprotection mediator, which is native and stable in human gastric juice, as well as easily applicable. Accordingly, there is interaction with many molecular pathways, combining maintained endothelium function and maintained thrombocytes function, which counteracted thrombocytopenia in rats that underwent major vessel occlusion and deep vein thrombosis and counteracted thrombosis in all vascular studies; the coagulation pathways were not affected. These appeared as having modulatory effects on NO-system (NO-release, NOS-inhibition, NO-over-stimulation all affected), controlling vasomotor tone and the activation of the Src-Caveolin-1-eNOS pathway and modulatory effects on the prostaglandins system (BPC 157 counteracted NSAIDs toxicity, counteracted bleeding, thrombocytopenia, and in particular, leaky gut syndrome). As an essential novelty noted in the vascular studies, there was the activation of the collateral pathways. This might be the upgrading of the minor vessel to take over the function of the disabled major vessel, competing with and counteracting the Virchow triad circumstances devastatingly present, making possible the recruitment of collateral blood vessels, compensating vessel occlusion and reestablishing the blood flow or bypassing the occluded or ruptured vessel. As a part of the counteraction of the severe vessel and multiorgan failure syndrome, counteracted were the brain, lung, liver, kidney, gastrointestinal lesions, and in particular, the counteraction of the heart arrhythmias and infarction.
Cosmology with the pairwise kinematic SZ effect: calibration and validation using hydrodynamical simulations

We study the potential of the kinematic Sunyaev-Zel'dovich (kSZ) effect as a probe for cosmology, focusing on the pairwise method. The main challenge is disentangling the cosmologically interesting mean pairwise velocity from the cluster optical depth and the associated uncertainties on the baryonic physics in clusters. Furthermore, the pairwise kSZ signal might be affected by internal cluster motions or correlations between velocity and optical depth. We investigate these effects using the Magneticum cosmological hydrodynamical simulations, one of the largest simulations of this kind performed to date. We produce thermal SZ and kSZ maps with an area of similar or equal to 1600 deg(2), and the corresponding cluster catalogues with M-500c greater than or similar to 3 x 10(13) h(-1) M-circle dot and z less than or similar to 2. From these data sets, we calibrate a scaling relation between the average Compton-y parameter and optical depth. We show that this relation can be used to recover an accurate estimate of the mean pairwise velocity from the kSZ effect, and that this effect can be used as an important probe of cosmology. We discuss the impact of theoretical and observational systematic effects, and find that further work on feedback models is required to interpret future high-precision measurements of the kSZ effect.
Measurement of the mass profile of abell 1689

In this letter we present calibrated mass and light profiles of the rich cluster of galaxies Abell 1689 out to 1 $h^{-1}$ Mpc from the center. The high surface density of faint blue galaxies at high redshift, selected by their low surface brightness, are unique tools for mapping the projected mass distribution of foreground mass concentrations. The systematic gravitational lens distortions of $10^4$ of these background galaxies in 15\arcmin\ fields reveal detailed mass profiles for intervening clusters of galaxies, and are a direct measure of the growth of mass inhomogeneity. The mass is measured directly, avoiding uncertainties encountered in velocity or X-ray derived mass estimates. Mass in the rich cluster Abell 1689 follows smoothed light, outside 100 h$^{-1}$ kpc, with a rest-frame V band mass-to-light ratio of $400 \pm 60$ $h^{-1} (M/L_V)_\odot$. Near the cluster center, mass appears to be more smoothly distributed than light. Out to a radius of 1 $h^{-1}$ Mpc the total mass follows a steeper than isothermal profile. Comparing with preliminary high resolution N-body clustering simulations for various cosmogonies on these scales, these data are incompatible with hot dark matter, a poor fit to most mixed dark matter models, and favor open or $\Lambda > 0$ cold dark matter. Substructure is seen in both the mass and the light, but detailed correspondence is erased on scales less than 100 $h^{-1}$ kpc.
Study of Leukopenia Induced by a High Dose of Cyclophosphamide in Mice

Abstract: The study was conducted to evaluate the toxic effect of different concentrations of cyclophosphamide (CTX) by inducing leukopenia. Adult female Swiss albino mice weighting (20±4g) arranged in three groups of six animals each housed. A control mice saline PBS solution (group I), mice treated with 200 mg/Kg (4mg/mouse) cyclophosphamide, High dose (group II) and mice treated with treated 100 mg/kg (2mg/mouse) body weight Low dose (group III) for three weeks. Cyclophosphamide causes a significant decrease (P < 0.01) in total leukocyte count (TLC), total erythrocyte count (TEC), and red blood cell distribution (RDW) in all groups compared to the control group of mice. Observed leukopenia inform marked reduced in the absolute numbers of lymphocytes, monocytes, and neutrophils in comparison to the control group of mice. The results indicate that cyclophosphamide alters the blood profile only after high doses while low doses had the least impact on blood pictures. Cyclophosphamide causes a significant increased (P < 0.01) in activity of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in serum after CTX treatment with no effect on the serum albumin level compared to the control group. While lower doses had less effect on liver enzymes.
Realistic voxel sizes and reduced signal variation in Monte-Carlo simulation for diffusion MR data synthesis

To synthesize diffusion MR measurements from Monte-Carlo simulation using tissue models with sizes comparable to those of scan voxels. Larger regions enable restricting structures to be modeled in greater detail and improve accuracy and precision in synthesized diffusion-weighted measurements. We employ a localized intersection checking algorithm during substrate construction and dynamical simulation. Although common during dynamics simulation, a dynamically constructed intersection map is also applied here during substrate construction, facilitating construction of much larger substrates than would be possible with a naive "brute-force" approach. We investigate the approach's performance using a packed cylinder model of white matter, investigating optimal execution time for simulations, convergence of synthesized signals and variance in diffusion-weighted measurements over a wide range of acquisition parameters. The scheme is demonstrated with cylinder-based substrates but is also readily applicable to other geometric primitives, such as spheres or triangles. The algorithm enables models with far larger substrates to be run with no additional computational cost. The improved sampling reduces bias and variance in synthetic measurements. The new method improves accuracy, precision, and reproducibility of synthetic measurements in Monte-Carlo simulation-based data synthesis. The larger substrates it makes possible are better able to capture the complexity of the tissue we are modeling, leading to reduced bias and variance in synthesised data, compared to existing implementation of MC simulations.
EXTREMELY LOW FREQUENCY RECEPTION AT KINGSTON, R. I.

Abstract : Magnetic fields of natural origin in the 5 to 20 c.p.s. frequency range were recorded in Kingston, R. I. The experimental equipment is described briefly, and results are presented. Variations with time of the first resonant frequency of the earth-ionosphere cavity are indicated, and effects of solar activity are discussed. An analysis of the envelope of recorded wave trains shows only fair agreement with existing theory. (Author)
Formulating Diets for Improved Health Status of Pigs: Current Knowledge and Perspectives

Simple Summary Today’s swine production systems are mostly intensive, and pigs are continuously exposed to pathogens and immune stimulatory antigens that may negatively impact productivity. It is known that immune system stimulation may reduce appetite, growth, and nutrient use efficiency compared to healthy animals. On the other hand, there is progressive pressure towards the reduction in antibiotic usage in livestock production, which highlights the need for furthering our understanding of the relationship between nutrition and the immune response. Swine nutritionists will need to consider the role of nutrition on health in order to develop programs that support production and robustness of pigs under a variety of stressful conditions. Among the nutritional strategies whose utilization may directly impact on the immune status of pigs, feeding low protein, amino acid-supplemented diets, supplementation of functional amino acids, dietary fiber level and source, diet complexity, organic acids, and plant secondary metabolites are at the forefront. As such, this review will discuss the impact of immune status on swine production and the interaction between nutrients and animal health, focusing on the roles of each nutritional strategy during times of immune challenge. Abstract Our understanding of nutrition has been evolving to support both performance and immune status of pigs, particularly in disease-challenged animals which experience repartitioning of nutrients from growth towards the immune response. In this sense, it is critical to understand how stress may impact nutrient metabolism and the effects of nutritional interventions able to modulate organ (e.g., gastrointestinal tract) functionality and health. This will be pivotal in the development of effective diet formulation strategies in the context of improved animal performance and health. Therefore, this review will address qualitative and quantitative effects of immune system stimulation on voluntary feed intake and growth performance measurements in pigs. Due to the known repartitioning of nutrients, the effects of stimulating the immune system on nutrient requirements, stratified according to different challenge models, will be explored. Finally, different nutritional strategies (i.e., low protein, amino acid-supplemented diets; functional amino acid supplementation; dietary fiber level and source; diet complexity; organic acids; plant secondary metabolites) will be presented and discussed in the context of their possible role in enhancing the immune response and animal performance.
Cosmological Constraints from the Evolution of the Cluster Baryon Mass Function at z ~ 0.5

We present a new method for deriving cosmological constraints based on the evolution of the baryon mass function of galaxy clusters and implement it using 17 distant clusters from our 160 deg2 ROSAT survey. The method uses the cluster baryon mass as a proxy for the total mass, thereby avoiding the large uncertainties of the Mtot-T or Mtot-LX relations used in all previous studies. Instead, we rely on a well-founded assumption that the Mb/Mtot ratio is a universal quantity, which should result in a much smaller systematic uncertainty. Taking advantage of direct and accurate Chandra measurements of the gas masses for distant clusters, we find strong evolution of the baryon mass function between z > 0.4 and the present. The observed evolution defines a narrow band in the Ωm-Λ plane, Ωm + 0. 23Λ = 0.41 ± 0.10 at 68% confidence, which intersects with constraints from the cosmic microwave background and Type Ia supernovae near Ωm = 0.3 and Λ = 0.7.
Spatially resolved spectroscopy across stellar surfaces

Context. Spectroscopy across spatially resolved stellar surfaces reveals spectral line profiles free from rotational broadening, whose gradual changes from disk center toward the stellar limb reflect an atmospheric fine structure that is possible to model by 3D hydrodynamics. Aims. Previous studies of photospheric spectral lines across stellar disks exist for the Sun and HD 209458 (G0 V) and are now extended to the planet-hosting HD 189733A to sample a cooler K-type star and explore the future potential of the method. Methods. During exoplanet transit, stellar surface portions successively become hidden and differential spectroscopy between various transit phases uncovers spectra of small surface segments temporarily hidden behind the planet. The method was elaborated in Paper I, in which observable signatures were predicted quantitatively from hydrodynamic simulations. Results. From observations of HD 189733A with the ESO HARPS spectrometer at λ/Δλ~ 115 000, profiles for stronger and weaker Fe I lines are retrieved at several center-to-limb positions, reaching adequate S/N after averaging over numerous similar lines. Conclusions. Retrieved line profile widths and depths are compared to synthetic ones from models with parameters bracketing those of the target star and are found to be consistent with 3D simulations. Center-to-limb changes strongly depend on the surface granulation structure and much greater line-width variation is predicted in hotter F-type stars with vigorous granulation than in cooler K-types. Such parameters, obtained from fits to full line profiles, are realistic to retrieve for brighter planet-hosting stars, while their hydrodynamic modeling offers previously unexplored diagnostics for stellar atmospheric fine structure and 3D line formation. Precise modeling may be required in searches for Earth-analog exoplanets around K-type stars, whose more tranquil surface granulation and lower ensuing microvariability may enable such detections.
Hyaluronic Acid And Its Role In Periodontal Healing

Hyaluronic acid is known as hyaluronan or hyaluronate, which has the function of increasing the mediator of periodontal regeneration. Hyaluronate acid has many roles in the early stages of inflammation, such as providing a structural framework through the interaction of hyaluronate with fibrin clots that modulate host inflammation and infiltration of the extracellular matrix of cells at the wound site so that this material becomes a therapeutic material used in various fields, especially in the field of periodontics. All periodontal tissues have shown the presence of hyaluronate, which is specifically concentrated in non-mineral tissues such as gingiva and periodontal ligament, which affects the growth, development, and repair of tissues in periodontal disease. The role of hyaluronic acid in periodontal healing will be discussed in this article.
Effective Communication and Campground Recycling: Lessons Learned from Yosemite, Grand Teton, and Denali National Parks

Outdoor recreation continues to be persistently high in national parks across the United States, particularly as the COVID-19 pandemic has led to increased use. In popular frontcountry destinations such as national park campgrounds managers are challenged with new issues more familiar to urban settings. One of these challenges is waste management. The largest source of visitor-generated waste in national parks is campgrounds. This research uses a mixed-methods approach to develop and test strategic communications designed to increase recycling and minimize trash to the landfill by altering campground visitor behaviors. Intercept surveys were used to create theory-based messages, and a quasi-experimental approach was used to evaluate message effectiveness. Our results show that messages emphasizing ease concepts were two times more effective at changing campground visitor waste disposal behaviors than control conditions. The results help inform the management of visitors as national parks strive to meet sustainability goals.
Localization of Energy-Momentum for a Black Hole Spacetime Geometry with Constant Topological Euler Density

The evaluation of the energy-momentum distribution for a new four-dimensional, spherically symmetric, static and charged black hole spacetime geometry with constant nonzero topological Euler density is performed by using the energy-momentum complexes of Einstein and Møller. This black hole solution was recently developed in the context of the coupled Einstein–nonlinear electrodynamics of the Born-Infeld type. The energy is found to depend on the mass M and the charge q of the black hole, the cosmological constant Λ, and the radial coordinate r, while in both prescriptions all the momenta vanish. Some limiting and particular cases are analyzed and discussed, illustrating the rather extraordinary character of the spacetime geometry considered.
EFFECT OF CORPORATE DIVERSIFICATION STRATEGIES ON THE FINANCIAL PERFORMANCE OF INDUSTRIAL GOODS IN NIGERIA

Business environment in Nigeria is becoming increasingly competitive, uncertain and complex. These changes are happening so fast that organisations that desire to remain in business must speedily adapt and adopt new strategies to meet the demands of the dynamic business environment. The research determines the effect of corporate diversification strategies on the financial performance of industrial goods. The research espoused the ex-post facto data from annual reports of the selected listed industrial goods companies on the Nigerian Stock Exchange (NSE) from 2012 to 2021. The least square regression analysis was used to evaluate the effect of the independent variables on the dependent variable. It was found that Income diversification has no significant effect on the return on assets of industrial goods companies in Nigeria. Also the study revealed that business segment diversification has considerable effect on the return on assets of industrial goods companies in Nigeria. It recommends that policy makers should promote policies that encourage listed firms to practice corporate diversification and companies should evaluate their strengths and weaknesses to enable them leverage on the opportunities presented by corporate diversification. Also, parent companies should ensure they are strategic while engaging in business segment diversification strategies. Keywords: Corporate Diversification, Financial Performance, Industrial Goods, Business Environment, Opportunities.
The Las Campanas Redshift Survey

The Las Campanas Redshift Survey (LCRS) consists of 26418 redshifts of galaxies selected from a CCD-based catalog obtained in the $R$ band. The survey covers over 700 square degrees in 6 strips, each 1.5$\arcdeg$ x 80$\arcdeg$, three each in the North and South galactic caps. The median redshift in the survey is about 30000 km~s$^{-1}$. Essential features of the galaxy selection and redshift measurement methods are described and tabulated here. These details are important for subsequent analysis of the LCRS data. Two dimensional representations of the redshift distributions reveal many repetitions of voids, on the scale of about 5000 km~s$^{-1}$, sharply bounded by large walls of galaxies as seen in nearby surveys. Statistical investigations of the mean galaxy properties and of clustering on the large scale are reported elsewhere. These include studies of the luminosity function, power spectrum in two and three dimensions, correlation function, pairwise velocity distribution, identification of large scale structures, and a group catalog. The LCRS redshift catalog will be made available to interested investigators at an internet web site and in archival form as an Astrophysical Journal CD-ROM.
PSR B0943+10: low-frequency study of subpulse periodicity in the Bright mode with LOFAR

We use broadband sensitive LOFAR observations in the 25–80 MHz frequency range to study the single-pulse emission properties of the mode-switching pulsar B0943+10. We review the derivation of magnetospheric geometry, originally based on low-frequency radio data, and show that the geometry is less strongly constrained than previously thought. This may be used to help explain the large fractional amplitudes of the observed thermal X-ray pulsations from the polar cap, which contradicted the almost aligned rotator model of PSR B0943+10. We analyse the properties of drifting subpulses in the Bright mode and report on the short-scale (minutes) variations of the drift period. We searched for the periodic amplitude modulation of drifting subpulses, which is a vital argument for constraining several important system parameters: the degree of aliasing, the orientation of the line-of-sight vector with respect to magnetic and spin axes, the angular velocity of the carousel, and thus, the gradient of the accelerating potential in the polar gap. The periodic amplitude modulation was not detected, indicating that it may be a rare or narrow-band phenomenon. Based on our non-detection and review of the available literature, we chose to leave the aliasing order unconstrained and derived the number of sparks under different assumptions about the aliasing order and geometry angles. Contrary to the previous findings, we did not find a large (of the order of 10%) gradual variation of the separation between subpulses throughout Bright mode. We speculate that this large variation of subpulse separation may be due to the incorrect accounting for the curvature of the line of sight within the on-pulse window. Finally, we report on the frequency-dependent drift phase delay, which is similar to the delay reported previously for PSR B0809+74. We provide a quantitative explanation of the observed frequency-dependent drift phase delay within the carousel model.
Field-Dependent Viscoelastic Properties of Graphite-based Magnetorheological Grease

This paper highlights the effect of graphite on the dynamic viscoelastic properties of magnetorheological grease (MRG). Two types of MRG namely MRG and graphite-MRG, GMRG with 0 wt. % and 10 wt. % of graphite respectively was synthesized by using a mechanical stirrer. The rheological properties of both sample at various magnetic field strength from 0 to 0.603 T was analyzed via rheometer under oscillatory mode with strain ranging from 0.001 to 1% with fixed frequency at 1 Hz for strain sweep and frequency ranging from 0.1 to 80 Hz at a constant strain of 0.01 % for frequency sweep. Based on the result obtained, the value of storage and loss modulus are dependent on the graphite content. A high value of storage modulus was achieved in the GMRG sample at all applied magnetic field strengths within all frequency ranges. These phenomena related to the contribution of graphite to forming the chain structure with CIPs and offered a more stable and stronger structure as compared with MRG. Moreover, the reduction in the value of loss modulus in GMRG was noticed compared to MRG at on-state conditions reflected by the stable structure obtained by GMRG. Lastly, both samples displayed a strong solid-like (elastic) behavior due to the high value of storage modulus, G’ acquired compared to loss modulus, G’’ at all frequency ranges. Therefore, the utilization of graphite in MRG can be used in wide applications such as brake and seismic dampers.