Miracle-dz/UniFAR-FTUs huggingface dataset:
Impact of known or new-onset atrial fibrillation on 2-year cardiovascular event rate in patients with acute coronary syndromes: results from the prospective EPICOR Registry

Background: Atrial fibrillation (AF) is associated with increased morbidity in acute coronary syndrome patients, but impact on outcomes beyond 1 year is unclear. Methods: This was a post-hoc analysis from the long-tErm follow-uP of antithrombotic management patterns In acute CORonary syndrome patients (EPICOR) registry (NCT01171404), a prospective, observational study conducted in Europe and Latin America, which enrolled acute coronary syndrome survivors at discharge. Antithrombotic management patterns, mortality, a composite endpoint of death/new non-fatal myocardial infarction/stroke and bleeding events were assessed after 2 years of follow-up in patients with or without AF. Results: Of 10,568 patients enrolled, 397 (4.7%) had prior AF and 382 (3.6%) new-onset AF during index hospitalisation. Fewer patients with AF underwent percutaneous coronary intervention (52.1% vs. 66.6%; P<0.0001). At discharge, fewer AF patients received dual antiplatelet therapy (71.6% vs. 89.5%; P<0.0001); oral anticoagulant use was higher in AF patients but was still infrequent (35.0% vs. 2.5%; P<0.0001). Use of dual antiplatelet therapy and oral anticoagulants declined over follow-up with over 50% of all AF/no AF patients remaining on dual antiplatelet therapy (55.6% vs. 60.6%), and 23.3% (new-onset AF) to 42.1% (prior AF) on oral anticoagulants at 2 years. At 2 years, mortality, composite endpoint and bleeding rates were higher in AF patients (all P<0.0001) compared to patients without AF. On multivariable analysis, the risk of mortality or the composite endpoint was significant for prior AF (P=0.003, P=0.001) but not new-onset AF (P=0.88, P=0.92). Conclusions: Acute coronary syndrome patients with AF represent a high-risk group with increased event rates during long-term follow-up. Prior AF is an independent predictor of mortality and/or ischaemic events at 2 years. Use of anticoagulants in AF after acute coronary syndrome is still suboptimal.
On characterizing the temporal dominance patterns of model parameters and processes

Diagnostic analyses of hydrological models intend to improve the understanding of how processes and their dynamics are represented in models. Temporal patterns of parameter dominance could be precisely characterized with a temporally resolved parameter sensitivity analysis. In this way, the discharge conditions are characterized, that lead to a parameter dominance in the model. To achieve this, the analysis of temporal dynamics in parameter sensitivity is enhanced by including additional information in a three‐tiered framework on different aggregation levels. Firstly, temporal dynamics of parameter sensitivity provide daily time series of their sensitivities to detect variations in the dominance of model parameters. Secondly, the daily sensitivities are related to the flow duration curve (FDC) to emphasize high sensitivities of model parameters in relation to specific discharge magnitudes. Thirdly, parameter sensitivities are monthly averaged separately for five segments of the FDC to detect typical patterns of parameter dominances for different discharge magnitudes. The three methodical steps are applied on two contrasting catchments (upland and lowland catchment) to demonstrate how the temporal patterns of parameter dynamics represent different hydrological regimes. The discharge dynamic in the lowland catchment is controlled by groundwater parameters for all discharge magnitudes. In contrast, different processes are relevant in the upland catchment, because the dominances of parameters from fast and slow runoff components in the upland catchment are changing over the year for the different discharge magnitudes. The joined interpretation of these three diagnostic steps provides deeper insights of how model parameters represent hydrological dynamics in models for different discharge magnitudes. Thus, this diagnostic framework leads to a better characterization of model parameters and their temporal dynamics and helps to understand the process behaviour in hydrological models. Copyright © 2015 John Wiley & Sons, Ltd.
Confirming a diagnosis of hereditary colorectal cancer : the impact of a Familial Bowel Cancer Registry in New Zealand

Aims This study estimated the impact of prevention, screening, early diagnosis, and treatment on the burden of melanoma in New Zealand. Methods Cancer control plans and management guidelines were reviewed to identify activities that could reduce the burden of melanoma in New Zealand and an estimation was made of their effects on incidence and mortality. The base year for estimating changes in incidence and mortality was the published melanoma data for 2002. Results The registration of melanoma increased from 1037 new registrations in 1993 to 1487 in 1994 and peaked at 1759 in 1995. In 2002 a further increase occurred, to 1842 new registrations and 235 deaths from melanoma. It is likely that 328 of the 1842 new cases of melanoma in 2002 were directly attributable to severe sunburn. A reduction of 10% in the number of people getting severely sunburnt could prevent 28 melanoma cases per year. If 2% of melanoma deaths occur in high-risk individuals, approximately 4 deaths per year could be prevented by surveillance of high-risk groups. Thin melanoma has a very good prognosis: a 10% shift in the depth distribution into the thinnest depth category would result in about 29 deaths from melanoma prevented each year. Conclusions The best avenues for reducing the burden of melanoma in New Zealand are prevention of excessive sun exposure and early diagnosis. Reducing severe sunburn and diagnosing a greater proportion of melanomas when they are thin would have the greatest impact on the incidence of and mortality from melanoma. The incidence and mortality rates of malignant melanoma have shown large increases in New Zealand over the past 30 years. Similar trends have also been observed in many other developed countries, but New Zealand and Australia still have the highest incidence rates in the world. While smaller increases in both incidence and mortality have been observed in people born after about 1950 in New Zealand, they have continued to increase for older people and in particular those aged over 60 years. Until the Cancer Registry Act 1993 came into force in New Zealand in July 1994, the Cancer Registry had been based primarily on public hospital records and so had missed many tumours excised outside hospital and many patients treated privately. Several studies have shown that incidence rates of melanoma estimated directly from pathology reports were considerably higher than was apparent from registered cases provided by the New Zealand Cancer Registry. Since the introduction of the Cancer Registry Act 1993, statutory notification has greatly increased the numbers of melanomas registered.
Development and application of a system for the analysis of atmospheric, water and sediment nitrogen and carbon

Eutrophication and climate change, key environmental concerns, are both linked to the carbon and nitrogen cycles hence the improved understanding of these cycles is essential. Currently, there is no system that simultaneously measures the fluxes of the three key gas phase products of nitrogen and carbon cycling (CO2, CH4 and N2O) in submerged ecosystems with hourly time resolution. A ”Lake-in-a-box” (mesocosm) was developed in the laboratory which allowed the monitoring of key components of the carbon and nitrogen cycles within the air, water and sediments. The approach is automated, simple and time efficient and novel in its ability to examine many different carbon and nitrogen compounds in all three physical component of the ”lake”. Dramatic fluctuations in gaseous flux and the concentrations of overlying water and sedimentary carbon and nitrogen compounds were noted over a three week period. These were split into five distinct phases which were linked to changes in sedimentary Nand C cycling. The results highlighted the important of links between the two cycles and supported recent studies showing that estuarine sediments can act as both a source and a sink of nitrogen.
21. GEOCHEMISTRY OF BROKEN RIDGE SEDIMENTS1

The present study involves the analysis and interpretation of geochemical data from a suite of sediment samples recovered at ODP Hole 752A. The samples encompass the time period that includes the lithospheric extension and uplift of Broken Ridge, and they record deposition below and above the mid-Eocene angular unconformity that denotes this uplift. A Q-mode factor analysis of the geochemical data indicates that the sediments in this section are composed of a mixture of three geochemical end members that collectively account for 94.2% of the total variance in the data. An examination of interelement ratios for each of these end members suggests that they represent the following sedimentary components: (1) a biogenic component, (2) a volcanogenic component, and (3) a hydrothermal component. The flux of the biogenic component decreases almost thirtyfold across the Eocene unconformity. This drastic reduction in the deposition of biogenic materials corresponds to the almost complete disappearance of chert layers, diatoms, and siliceous microfossils and is coincident with the uplift of Broken Ridge. The volcanogenic component is similar in composition to Santonian ash recovered at Hole 755A on Broken Ridge and is the apparent source of the Fe-stained sediment that immediately overlies the angular unconformity. This finding suggests that significant amounts of Santonian ash were subaerially exposed, weathered, and redeposited and is consistent with data that suggest that the vertical uplift of Broken Ridge was both rapid and extensive. The greatest flux of hydrothermal materials is recorded in the sediments immediately below the angular unconformity. This implies that the uplift of Broken Ridge was preceded by a significant amount of rifting, during which faulting and fracturing of the lithosphere led to enhanced hydrothermal circulation. This time sequence of events is consistent with (but not necessarily diagnostic of) the passive model of lithospheric extension and uplift.
EVALUATION OF HEAVY METAL CONTAMINATION IN THE ESTUARIES OF CHENNAI

Chennai, the fourth largest metropolitan city in India has undergone rapid urbanization and industrial developments in recent years. This has resulted in the accumulation of hazardous pollutants and toxic metals in the aquatic ecosystems. The present study is carried out to study contamination of Cr, Pb, As and Cd in Ennore, Pulicat and Muttukadu estuaries surrounding Chennai. Among the metals analyzed, Cr was found to be deposited in higher concentration. This was followed by Pb, As and Cd. The concentration of all the metals was found to remarkably very high in the Ennore estuary
Perioperative blood transfusion and outcome after resection for colorectal carcinoma

The degree of immunomodulation by perioperative blood transfusion and its effect on oncological surgery remain controversial. A major problem with previous clinical studies has been the inadequate patient population in each and the presence of confounding variables. To resolve some of the controversy, all studies published between 1982 and 1990 were reviewed using the statistical method of Mantel–Haentszel–Peto to determine a cumulative estimate of the direction and magnitude of this association. Some 20 papers were included in the analysis, representing 5236 patients. The cumulative odds ratios (95 per cent confidence interval) of disease recurrence, death from cancer and death from any cause were 1.80 (1.30–2.51), 1.76 (1.15–2.66) and 1.63 (1.12–2.38) respectively. These results support the hypothesis that perioperative blood transfusion is associated with an increased risk of recurrence of colorectal carcinoma and death from this malignancy.
Assessment on pollution impact and correlation study of lake water from Thane region of Maharashtra, INDIA

Water is a source of life. But pollution of water is the biggest threat in today’s world. Thane city of Maharashtra state is known for its beautiful lakes. It has many lakes as per the record of Thane Municipal Corporation. As most of these water bodies situated right next to the roads receive heavy flux of agricultural waste, domestic sewage, industrial waste thus deteriorating water quality. The increasing trend in concentration of heavy metals in the environment has created lot of awareness about environmental pollution. These heavy metals have a marked effect on the aquatic flora and fauna which through bio magnification enter the food chain thereby affecting the human being. Hence this study is carried out to assess the quality of water in lake water samples from eight different lakes. Physico- chemical analysis is done over the period of march 2013 to February 2014 to estimate the parameters such as pH , conductivity, alkalinity, salinity, hardness, chemical Oxygen Demand(COD), Dissolved Oxygen (DO), Biological Oxygen Demand, Total Dissolved Solid and heavy metal content like Cu,Hg,As and Fe . The study shows high level of BOD ranging from 15mg/l ( minimum) to 67mg/l (maximum). Very low level of dissolved oxygen in water indicates pollution. As the quality of water greatly affect the all forms of life , this attempt has made to asses and monitore the quality by studing physico-chemical properties of water .
A Time Varying Parameter Structural Model of the UK Economy

Abstract We estimate a time-varying parameter structural macroeconomic model of the UK economy, using a Bayesian local likelihood methodology. This enables us to estimate a large open-economy DSGE model over a sample that comprises several different monetary policy regimes and an incomplete set of data. Our estimation identifies a gradual shift to a monetary policy regime characterised by an increased responsiveness of policy towards inflation alongside a decrease in the inflation trend down to the two percent target level. The time-varying model also performs remarkably well in forecasting and delivers statistically significant accuracy improvements for most variables and horizons for both point and density forecasts compared to the standard fixed-parameter version.
Chapter 5 Adaptive and Personalized Learning Based on Students ’ Cognitive Characteristics

Working memory capacity (WMC) is a cognitive characteristic that affects students’ learning behaviors to perform complex cognitive tasks. However, WMC is very limited and can be easily overloaded in learning activities. Considering students’WMC through personalized learning materials and activities helps in avoiding cognitive overload and therefore positively affects students’ learning. However, in order to consider students’ WMC in the learning process, an approach is needed to identify students’ WMC without any additional efforts from students. To address this problem, we introduce a general approach to automatically identify WMC from students’ behavior in a learning system. Our approach is generic and designed to work with different learning systems. Furthermore, by knowing students’ WMC, a learning system can provide teachers meaningful recommendations to support students with low and high WMC. Accordingly, we created a recommendation mechanism that provides recommendations based on the guidelines of cognitive load theory. These recommendations are intended to assist in presentation T. -W. Chang (&) J. Kurcz M.M. El-Bishouty Kinshuk S. Graf Athabasca University, 1 University Drive Athabasca, AB T9S 3A3 Edmonton, Alberta, Canada e-mail: tingwenchang@athabascau.ca J. Kurcz e-mail: jkurcz@gmail.com M.M. El-Bishouty e-mail: moushir.elbishouty@athabascau.ca Kinshuk e-mail: kinshuk@athabascau.ca S. Graf e-mail: sabineg@athabascau.ca T. -W. Chang M.M. El-Bishouty Kinshuk S. Graf 1200, 10011-109 Street, Edmonton AB T5J 3S8, Canada J. Kurcz 1324 Hansen Cres, Windsor, ON N8W 5M8, Canada © Springer-Verlag Berlin Heidelberg 2015 Kinshuk and R. Huang (eds.), Ubiquitous Learning Environments and Technologies, Lecture Notes in Educational Technology, DOI 10.1007/978-3-662-44659-1_5 77 sabineg@athabascau.ca of information in order to reduce working memory overload. Information about WMC is also the basis for designing adaptive systems that can automatically provide students with individualized support based on their WMC.
Influence of different sites on Lilium flower and bulb production in cold desert region of Himachal Pradesh, India.

The present study was conducted in LahaulValley of Himachal Pradesh in North western Himalayas with the objective to know the influence of different sites on cut flower and bulb production in different groups of lilium hybrids. During the study an intensive survey was conducted and data were collected on existing genotypes from four different sites located at different altitudes viz., Kuthvihal (10302 feet), Gondhla (10726 feet), Dalang (9781 feet) and Phura (9600 feet). The results showed that bulbs grown at Dalang site had shorter growing cycle than those grown at other two sites. Plant height and number of flowers per stem were comparable except for Asiatic hybrid ‘Navona’ at Dalang and Gondhla; Oriental hybrids ‘Rubato’, ‘Tiara’ and ‘Mother Choice’ showed a lower number of flowers per stem at Dalang. The three main hybrid groups behaved differently according to temperature conditions. Asiatic and Oriental hybrids were better adapted to cooler climates. Fresh weight of Asiatic hybrids ‘Navona’ and ‘Brunello’ were significantly higher at Dalang, Kuthvihal and Phura. In Oriental hybrids fresh weight and size of harvested bulbs were higher at Kuthvihal. Moreover, the results indicated that dry temperate regions of Himachal Pradesh are suitable for quality cut flower and bulb production of lilium.
48. THE EVOLUTION OF ANTARCTIC SURFACE WATERS DURING THE PALEOGENE: INFERENCES FROM THE STABLE ISOTOPIC COMPOSITION OF PLANKTONIC FORAMINIFERS, ODP LEG 113 1

The oxygen and carbon isotopic composition has been measured for numerous Paleogene planktonic foraminifer species from Maud Rise, Weddell Sea (ODP Sites 689 and 690), the first such results from the Antarctic. The results provide information about large-scale changes in the evolution of temperatures, seasonally, and structure of the upper water column prior to the development of a significant Antarctic cryosphere. The early Paleocene was marked by cooler surface-water conditions compared to the Cretaceous and possibly a less well developed thermocline. The late Paleocene and early Eocene saw the expansion of the thermocline as Antarctic surface waters became warm-temperate to subtropi­ cal. The late Paleocene to early Eocene thermal maximum was punctuated by two brief excursions during which time the entire Antarctic water column warmed and the meridional temperature gradient was reduced. The first of these ex­ cursions occurred at the Paleocene/Eocene boundary, in association with a major extinction in deep sea benthic fora­ minifers. The second excursion occurred within the early Eocene at —54.0 Ma. These excursions are of global impor­ tance and represent the warmest intervals of the entire Cenozoic. The excursions were associated with fundamental changes in deep-water circulation and global heat transport. The thermal maximum of the early Eocene ended with the initiation of a long-term cooling trend at 52.0 Ma. This cooling trend was associated with reduced seasonality, and diminished structure and/or duration of the seasonal ther­ mocline. The cooling trend was punctuated by three major cooling steps at 43.0, 40.0, and -36.0 Ma.
Bio-Economic Response of Autumn Sugarcane to Soil Variation , NPK Management and planting Geometry under Arid Climate

Autumn sugarcane crop is commonly fertilized @ 175-60-60 and 300-175-125 NPK kg ha in sandy loam and silty clay soils, respectively. Whether these fertilizer doses are sufficient or otherwise for the fulfillment of this sugarcane crop demand is yet to be established. A comprehensive study (2005-06 to 2007-08) was conducted to identify the optimum NPK dose in sandy loam and silty clay soils. This study was conducted on autumn sugarcane cv. HSF 240 at two different locations, Land Reclamation Research Station 37/TDA, Bhakkar and Gomal University Dera Ismail Khan, Pakistan. The experiments were laid out according to randomized complete block design with factorial arrangement. The trial was replicated four times with net plot of 24 m.Five NPK doses i.e. F0 (0-0-0), F1 (100-100-100), F2 (150-150-100), F3 (200-200-100) and F4 (250-200-100) kg haalongwith four planting arrangements i.e. G1 (60cm), G2 (75cm) single row planting patterns, G3 (30/90cm) and G4 (30/120cm) spaced paired row strip planting patterns were tested. Statistical analysis of three years pooled data showed that NPK doses affected the sugar yield contributing parameters, significantly. Maximum shoot dry weight (1900.8 & 1949.2 g m) was recorded in F4 × G3, while minimum in F0×G4 (624.8 & 629.2 g m) on sandy loam and silty clay soil, respectively. Maximum sugar yield (14.81 & 15.52 t ha) was recorded in F4×G3 and minimum (3.66 & 4.03t ha) in F0×G1 on sandy loam and silty clay soils. Maximum sugar recovery (11.5 and 10.90%) was recorded in the treatment interaction of F0×G4 and minimum (7.67 and 8.64%) in F4×G1 on sandy loam and silty clay soils. Maximum FUE (289.4 & 290.2 kg kg ) was obtained in treatment interaction of F3×G3 on both soils. It was concluded that maximum sugar yield, BCR and FUE from nutrient dose of 200–200-100 kg NPK ha cum 30/90cm spaced paired row strip planting can be harvested in sandy loam and silty clay soils in arid climate. Sugar recovery percentage was recorded maximum in interaction of control and 30/120cm spaced paired row strip planting. Nutrient application of 200-200-100 NPK kg ha having planting geometry of 30/90 cm paired row strips planting was proved optimum for maximum sugar yield.
Sheffield Economic Research Paper Series SERP Number : 2004008

It is estimated that by 2001 20 million people had died from AIDS, which is now the world’s fourth biggest cause of death. While the highest prevalence and death rates and number of infected persons are reported for sub-Saharan Africa, where life expectancies at birth are declining rapidly and infant mortality rates are increasing, there is evidence that the epidemic is accelerating in Asia and Eastern Europe. While the human and social costs of the HIV/AIDS epidemic are the major causes for concern, the econometric results reported in this paper indicate that the macroeconomic affects of the HIV/AIDS epidemic have been substantial; especially in Africa where the average marginal negative impact on income per capita of a one percent increase in HIV prevalence rate is 0.59 percent. Even in countries where the HIV prevalence rates are lower the marginal impacts are non trivial.