Miracle-dz/UniFAR-FTUs huggingface dataset:
The OsHKT1;1 Transporter is Involved in Salt Tolerance and 10 Regulated by an MYB-Type Transcription Factor 1

37 Sodium transporters play key roles in plant tolerance to salt stress. Here, we report 38 that a member of the High-Affinity K + Transporter (HKT) family, OsHKT1;1, in rice 39 ( Oryza sativa L. cv. Nipponbare) plays an important role in reducing Na + 40 accumulation in shoots to cope with salt stress. The oshkt1;1 mutant plants displayed 41 hypersensitivity to salt stress. They contained less Na + in the phloem sap and 42 accumulated more Na + in the shoots compared to the wild type. OsHKT1;1 was 43 expressed mainly in the phloem of leaf blades and up-regulated in response to salt 44 stress. Using a yeast one-hybrid approach, a novel MYB coiled-coil type transcription 45 factor, OsMYBc, was found to bind to the OsHKT1;1 promoter. In planta chromatin 46 immunoprecipitation and in vitro electrophoresis mobility shift assays demonstrated 47 that OsMYBc binds to AAANATNC(C/T) fragments within the OsHKT1;1 promoter. 48 Mutation of the OsMYBc -binding nucleotides resulted in a decrease in promoter 49 activity of OsHKT1;1 . Knockout of OsMYBc resulted in a reduction in NaCl-induced 50 expression of OsHKT1;1 and salt sensitivity. Taken together, these results suggest that 51 OsHKT1;1 has a role in controlling Na + concentration and preventing sodium toxicity 52 in leaf blades, and is regulated by the OsMYBc transcription factor. 53
EFFECTS OF MODIFIABLE RISK FACTORS ON COGNITION IN ELDERLY PEOPLE A STUDY AT TERTIARY CARE HOSPITAL

The 3MS is significantly better predictor of functional outcome than the MMSE and is found to higher sensitivity. [10] our study. There studies involving correlation of various physiological factors with cognition in elderly people in India. This study finds the correlation of various modifiable risk factors like smoking, alcohol, hypertension and diabetes with cognitive impairment in elderly people. By this study elderly persons with high risk of developing dementia can be found out and proper preventive strategies can be implemented early. ABSTRACT Background: With rapidly increasing number of older people in our community cognitive impairment is a growing public health concern in India. A number of health and life style factors contribute to cognitive decline in old people. The aim of this study is to evaluate the effect of modifiable risk factors like smoking, alcohol, hypertension and diabetes on cognition in elderly persons. Method: We examined 100 elderly people above 60 years by Mini Mental State Examination (MMSE) and Modified Mini Mental status Examination (3MS) and found association of smoking, alcohol, diabetes and hypertension with cognition. Statistical analysis was done using SPSS software by chi square and independent t test and p value < 0.05 was considered to be statistically significant. Results: We found significant decrease in cognitive scores in smokers, alcoholics, hypertensives and diabetics when compared with non smokers, non alcoholics, normotensives and non diabetics (p < 0.001). There was a significant decrease in MMSE and 3MS scores in persons with all four risk factors present when compared with persons having no risk factor (p<0.001). Conclusion: Modifiable risk factors play a significant role in cognitive impairment in elderly people. Old people with risk factors should be screened for dementia regularly. Early identification of people with cognitive impairment, evaluating and giving appropriate treatment may slow down the progress of dementia.
An AutomatedSystemfor KineticMultiple-PointDeterminations Exemplifiedby Serum LacticDehydrogenaseDetermination

A fully automated procedure is presented for kinetic determinations and for use of the AutoAnalyzer in their study; serum lactic dehydrogenase has been used to illustrate such an application. The LDH-catalyzed oxidation of L-lactate by NAD in separate, unequal timedelay coils is determined by measuring the natural fluorescence of reduced coenzyme. The normal range for LDH activity by this method was 63-169 U/liter at 37#{176}C.
Interval Entropy Proﬁle Method Based on Maximum Entropy Principle for Estimating Evolutionary Information Content in Genetic Sequences for Their Comparison

—Two classes of computational algorithms have been applied to solve the most fundamental problem in Bioinformatics-sequence comparison. Due to computational limitation in alignment methods, alignment-free methods become a predominant approach for devising sequence similarity. Of the alignment-free methods, return time distribution(RTD) based approaches are widely applied to answer various biological queries. However, existence of sequence noise becomes a principle bottle-neck to achieve precision in results for RTD approaches. Additionally, use of single length for k-mer strings often neglects evolutionary information that can be extracted using k-mers of other lengths. I inspect these ﬂaws and propose a new method that considers multiple lengths of k-mer strings for generating features. Markovian dependency is assumed to estimate expected distribution for k-mer strings and to reduce sequence noise. Additionally, a criteria based on uniform independent model of sequence composition for selecting maximum k value is used. Experiments on benchmark datasets of 18s-rRNA sequence and whole genome mitochondrial(mtDNA) sequence of eutherians orders show superiority of the proposed method over all existing RTD and two start-of-the-art non-RTD methods.
EFFECT OF DIVIDEND PAYING BEHAVIOR AND BOARD SIZE AND BOARD COMPOSITION ON FIRM’S PERFORMANCE: EVIDENCE FROM PAKISTAN

This study examines the impact of corporate governance (board size and board composition), dividend-paying behavior on financial performances. We used panel data including a sample of 5 major sectors (cement, textile, board & paper, power, oil& gas) of Pakistan. The data of study covers from 2006 to 2016. We used board size and board composition as corporate governance, dividend-covering ratio used for measuring dividend-paying behavior, return on assets and return on equity is used for performance, which is dependent variable. For the data normality test, we measure descriptive statistics and correlation and for analyzing the main results, we used Estimated Generalized Least Square (EGLS) model . The findings suggest that there is significant positive relationship between dividend coverage and firm performance. The general reserve are also positive relationship with profitability which enhance the overall performance of non-financial sectors of Pakistan.
Heart Failure Stages Among Older Adults in the CommunityClinical Perspective

Background: Although heart failure (HF) disproportionately affects older adults, little data exist regarding the prevalence of American College of Cardiology/American Heart Association HF stages among older individuals in the community. Additionally, the role of contemporary measures of longitudinal strain and diastolic dysfunction in defining HF stages is unclear. Methods: HF stages were classified in 6118 participants in the Atherosclerosis Risk in Communities study (67–91 years of age) at the fifth study visit as follows: A (asymptomatic with HF risk factors but no cardiac structural or functional abnormalities), B (asymptomatic with structural abnormalities, defined as left ventricular hypertrophy, dilation or dysfunction, or significant valvular disease), C1 (clinical HF without prior hospitalization), and C2 (clinical HF with earlier hospitalization). Results: Using the traditional definitions of HF stages, only 5% of examined participants were free of HF risk factors or structural heart disease (Stage 0), 52% were categorized as Stage A, 30% Stage B, 7% Stage C1, and 6% Stage C2. Worse HF stage was associated with a greater risk of incident HF hospitalization or death at a median follow-up of 608 days. Left ventricular (LV) ejection fraction was preserved in 77% and 65% in Stages C1 and C2, respectively. Incorporation of longitudinal strain and diastolic dysfunction into the Stage B definition reclassified 14% of the sample from Stage A to B and improved the net reclassification index ( P =0.028) and integrated discrimination index ( P =0.016). Abnormal LV structure, systolic function (based on LV ejection fraction and longitudinal strain), and diastolic function (based on e’, E/e’, and left atrial volume index) were each independently and additively associated with risk of incident HF hospitalization or death in Stage A and B participants. Conclusions: The majority of older adults in the community are at risk for HF (Stages A or B), appreciably more compared with previous reports in younger community-based samples. LV ejection fraction is robustly preserved in at least two-thirds of older adults with prevalent HF (Stage C), highlighting the burden of HF with preserved LV ejection fraction in the elderly. LV diastolic function and longitudinal strain provide incremental prognostic value beyond conventional measures of LV structure and LV ejection fraction in identifying persons at risk for HF hospitalization or death. # Clinical Perspective {#article-title-62}
The effect of psychological ownership on Job satisfaction of airports supply chain staff (Case study: supply chain part pilot training airport)

Background and aims: Job satisfaction is an important factor in increasing productivity, caring staff to the organization, belonging and attachment to the workplace and increasing the quantity and quality of work and good human relations in the workplace, good communication, raising spirit, love and Interest of the job. The purpose of this study was to investigate the effect of psychological ownership on job satisfaction among airports supply chain staff. Methods: Using random sampling, 59 employees were selected for this study. To measure psychological ownership and job satisfaction questionnaires Van Dyne and Pierce and Minnesota, respectively have been used.Data’s analyzed by correlation and regression and Structural Equation Modeling. Results: Result showed that psychological ownership with load factor (0.866) and had effect on Job satisfaction and organizational -based psychological ownership with beta (0.112) and meaningfully (0.002) follow job-based psychological ownership with beta (0.235) and meaningfully (0.001) has positive relationship with Job satisfaction. Conclusion: Since there is a positive effect of job satisfaction on psychological ownership, and create a positive attitude toward employees and job creation in the ownership and belonging, increase productivity, increase organizational commitment, establish a good in person, the creation of a proper relationship raise morale and interest in the organization.
DELINEATION OF LPS-BINDING SITES ON HEMOGLOBIN – FROM IN SILICO PREDICTIONS TO BIOPHYSICAL CHARACTERIZATION

Background: Redox of (Hb) is augmented by lipopolysaccharide (LPS) to boost immune defense. Results: Computational analysis of Hb identified LPS-binding hotspots, which were further defined via peptide-based binding assays and confirmed by mutagenesis of Hb subunits. Conclusion: Regions of Hb which interact with LPS have been delineated. Significance: Knowledge of LPS-binding residues on Hb may be exploited for designing antimicrobial peptides.
An Update on the General Features of Breast Cancer in Male Patients—A Literature Review

Male breast cancers are uncommon, as men account for less than 1 percent of all breast carcinomas. Among the predisposing risk factors for male breast cancer, the following appear to be significant: (a) breast/chest radiation exposure, (b) estrogen use, diseases associated with hyper-estrogenism, such as cirrhosis or Klinefelter syndrome, and (c) family health history. Furthermore, there are clear familial tendencies, with a higher incidence among men who have a large number of female relatives with breast cancer and (d) major inheritance susceptibility. Moreover, in families with BRCA mutations, there is an increased risk of male breast cancer, although the risk appears to be greater with inherited BRCA2 mutations than with inherited BRCA1 mutations. Due to diagnostic delays, male breast cancer is more likely to present at an advanced stage. A core biopsy or a fine needle aspiration must be performed to confirm suspicious findings. Infiltrating ductal cancer is the most prevalent form of male breast cancer, while invasive lobular carcinoma is extremely uncommon. Male breast cancer is almost always positive for hormone receptors. A worse prognosis is associated with a more advanced stage at diagnosis for men with breast cancer. Randomized controlled trials which recruit both female and male patients should be developed in order to gain more consistent data on the optimal clinical approach.
A New Universal Follicular Unit Excision Classification System for Hair Transplantation Difficulty and Patient Outcome

Introduction The difficulty of the follicular unit excision (FUE) hair transplantation procedure is currently attributed to hair curliness and subsurface angulation. Patients possessing the curliest hair shafts are considered the most challenging. Consequently, patients with these features are often denied FUE. However, this practice does not consider intrapatient variation in the graft attrition rate and the rates themselves, which are frequently low in very curly hair where the skin firmness/thickness is average. To better aid practitioners in predicting FUE performance, we have developed a new scoring system (the Sanusi FUE Score Scale [SFS Scale]) based on two major donor variables (hair and skin characteristics). Material and Method The scale assigns scores to each of three hair subtypes (straight-wavy, curly, and coily-kinky) and each of three skin subtypes (thick/firm, soft/thin, and medium thickness/firmness). The scores were weighted based on the assessment of 13 experienced FUE practitioners from around the globe, who were asked to score each of the three skin and hair characteristics for their contribution to FUE difficulty. Results On the contribution of skin characteristics to FUE difficulty, 12/13 (92%) practitioners assigned the highest (most difficult) score to thick/firm skin, with medium skin thickness/firmness being the least challenging. The same percentage of practitioners gave the highest difficulty score to coiled-kinky hair subtypes regarding the contribution of hair characteristics to FUE difficulty. All agreed that straight-wavy hair presents the least challenge to FUE performance. Tallying the scores of the skin and hair variables generates a final score range of 2–9, which is associated with five grades/classes of challenge in the FUE procedure, influencing the need for a specialized skill/nuanced approach or equipment. Conclusion We developed a universal FUE donor scoring scale that accounts for the diversity of human hair and skin types. Further evaluation to determine the validity of this new classification system in predicting and grading FUE difficulty and patient outcomes is warranted.
Fixing critical limits of boron in rice soils of Karaikal region, Puducherry union territory, India

Boron is relatively immobile in plants and its deficiency can cause serious yield reduction in rice by retarding panicle formation. Karaiakal region of Puduchuerry union terittory includes different soils with varying fertility status thus supplying boron at optimum level is a must concern to enhance the rice productivity.A pot experiment was conducted to fix critical limits of boron in soils and rice of this Karaikal region. Forty surface soil samples (0-15 cm) were collected from Inceptisol, Entisol and Vertisol soil orders of different locations in Karaikal region. The experiment was conducted with three levels of boron viz., 0, 1 and 2 ppm applied through borax in a factorial completely randomized design with three replications. The available B content of soil was estimated with five extractants. The critical limits of hot water, hot 0.01 M CaCl2, 0.05 M HCl, 1.0 M NH4OAc, 0.01M CaCl2+ 0.05 M Mannitol extractable B were found to be 0.50, 0.58, 0.46, 0.45 and 0.39 ppm in Inceptisol, 0.48, 0.59, 0.44, 0.39 and 0.48 ppm in Entisol and 0.45, 0.54, 0.45, 0.44 and 0.41ppm in Vertisol and a critical limit of 31.0, 39.0 and 34.0 ppm B in rice plant for Inceptisol(0.5ppm), Entisol(0.48 ppm) and Vertisol(0.45 ppm) as determined by Cate and Nelson’s graphical procedure. Among the extractants the hot water extractant showed the highest significant and positive correlation with Bray’s percent yield(0.48,0.47and 0.48), plant B content(0.041*, 0.019* and 0.271*) and B uptake(0.012*, 0.646* and 0.293*), respectively in Inceptisol, Entisol and Vertisol. From this study, the indicating knowledge of critical limit of boron will help to avoid yield loss of rice in the study region.
Classroom Movement Breaks and Physically Active Learning Are Feasible, Reduce Sedentary Behaviour and Fatigue, and May Increase Focus in University Students: A Systematic Review and Meta-Analysis

Background: University students are mostly sedentary in tertiary education settings which may be detrimental to their health and learning. This review aimed to examine the feasibility and efficacy of classroom movement breaks (CMB) and physically active learning (PAL) on physical and cognitive outcomes in university students in the tertiary setting. Methods: Five electronic databases (MEDLINE, CINAHL, Embase, PsychINFO, and PubMed) were searched for articles published up until November 2021. Manual searching of reference lists and citation tracking were also completed. Two reviewers independently applied inclusion and exclusion criteria and completed quality assessment. Articles were included if they evaluated CMB or PAL interventions delivered to university students in a tertiary setting. Results: Of the 1691 articles identified, 14 studies with 5997 participants met the inclusion criteria. Average study quality scores were poor for both CMB and PAL studies. CMBs and PAL are feasible in the tertiary setting and increase physical activity, reduce sedentary behaviour, increase wellbeing, and reduce fatigue in university students. In addition, CMBs increased student focus and attention in class and PAL had no detrimental effect on academic performance. Conclusions: University educators should feel confident in introducing CMB and/or PAL interventions into their classes to improve student health and wellbeing.
University of Birmingham Primary B lymphocytes infected with KSHV can be expanded in vitro and are recognized by LANA-specific CD4+ T cells

Primary B lymphocytes infected with KSHV can be expanded in vitro and are recognized LANA-specific T cells. Abstract Kaposi sarcoma-associated herpesvirus (KSHV) has a tropism for B lymphocytes in which it 19 establishes latency and can also cause lymphoproliferative disorders of these cells 20 manifesting as primary effusion lymphoma (PEL) and multi-centric Castleman disease 21 (MCD). T cell immunity is vital for the control of KSHV infection and disease however few 22 models of B lymphocyte infection exist to study immune recognition of such cells. Here we 23 developed a model of B lymphocyte infection with KSHV where infected tonsillar B 24 lymphocytes were expanded by providing mitogenic stimuli and these challenged with 25 KSHV-specific CD4+ T cells. Infected cells expressed viral proteins found in PELs namely 26 LANA and vIRF3, albeit at lower levels, with similar patterns of gene expression for the 27 major latency, vIL-6 and vIRF3 transcripts. Despite low level expression of ORF50, 28 transcripts for the immune evasion genes K3 and K5 were detected, with some 29 downregulation of cell surface expressed CD86 and ICAM. The vast majority of infected 30 lymphocytes expressed IgM and the Ig λ light chain, recapitulating these features seen in 31 infected cells in MCD. We assessed the ability of the infected lymphocytes to be targeted by 32 a panel of MHC class II matched CD4+ T cells and found that LANA-specific T cells 33 restricted to different epitopes recognized these infected cells. Given that at least some 34 KSHV latent antigens are thought to be poor targets for CD8+ T cells, we suggest that CD4+ 35 T cells are potentially important effectors for the in vivo control of KSHV infected B 36 lymphocytes.
Perceptions of Telehealth Services for Hearing Loss in South Africa’s Public Healthcare System

Telehealth promises increased access to hearing healthcare services, primarily in areas where hearing healthcare resources are limited, such as within the South African public healthcare system. Telehealth for hearing healthcare is especially important during the COVID-19 pandemic, where physical distancing has been essential. This study aimed to describe audiologists’ perceptions regarding telehealth services for hearing loss within South Africa’s public healthcare system. This study was divided into two phases. During Phase 1, 97 audiologists completed an electronic survey regarding their perceptions of telehealth for hearing loss within South African public sector hospitals. Synchronous virtual focus-group discussions were conducted during Phase 2. Results indicated that audiologists recognized telehealth services’ potential to improve hearing healthcare efficiency within the public sector, and most (84.1%) were willing to use it. However, telehealth’s actual uptake was low despite almost doubling during the COVID-19 pandemic. Prominent perceived barriers to telehealth were primarily related to hospital resources, including the unavailability of equipment for the remote hearing/specialized assessments, internet-related barriers, and limited IT infrastructure. An increased understanding of telehealth in South Africa’s public healthcare system will assist in identifying and in improving potential barriers to telehealth, including hospital resources and infrastructure.
Local Building Regulators’ Institutionalised Behaviour Towards Mass Customised Housing (MCH)

Mass Customised Housing (MCH) is an innovation in house production that could potentially transform developers’ business models due to its buyer-friendly template by offering customised houses that can fulfil part or most of buyer’s housing requirements at reasonable prices, thus securing customer loyalty and market share in the long run. Thus far, the body of literature on MCH only focuses either on the technical or the financial side of MCH implementation, with a discernible lacuna in the regulatory response. A broad institutional approach frames this study whereby a questionnaire survey with close and open ended questions was conducted on local building regulators to examine their attitude towards MCH and to explore potential issues pertaining to MCH implementation. A total of 133 questionnaires were sent to building regulators in Peninsular Malaysia, with a response rate of 28.6%. Quantitative data was analysed to yield descriptive statistics whilst qualitative data was analysed based on thematic analysis. Quantitative results showed a strong positive acceptance of MCH within the current regulatory environment, yet qualitative findings revealed respondents’ concerns about stakeholders’ disconnect, MCH’s compatibility with the current system and development actors’ actual motivations. Findings give an insight into the attitude of local building regulators in balancing their statutory roles with furthering developers’ economic objectives and house buyers’ social objectives. Keywords: Mass Customised Housing (MCH), local building regulators, housing innovation, institutionalised behaviour