Miracle-dz/UniFAR-FTUs huggingface dataset:
Impact of a Mindfulness-Based Intervention on Basic Psychological Need Satisfaction and Internalized Symptoms in Elementary School Students With Severe Learning Disabilities: Results From a Randomized Cluster Trial

Background Mindfulness is hypothesized to lead to more realistic appraisals of the three basic psychological needs, which leads people to benefit from high levels of need satisfaction or helps them make the appropriate changes to improve need satisfaction. Mindfulness-based interventions (MBIs) have also shown promise to foster greater basic psychological need satisfaction in students with learning disabilities (LDs). Objective The goal of the present study was to evaluate the impact of a MBI on the satisfaction of the basic psychological needs and on internalized symptoms in students with severe LDs. A randomized cluster trial was implemented to compare the progression of need satisfaction, anxiety, and depression symptoms in participants pre- to post-intervention and at follow-up. Method Elementary school students with severe LDs (N = 23) in two special education classrooms took part in this study and were randomly attributed to either an experimental or an active control group. Results Mixed ANOVAs first showed that the experimental condition did not moderate change over time such that similar effects were observed in the experimental and active control groups. Looking at main effects of time on participants’ scores of autonomy, competence, and relatedness across time, we found a significant within-person effect for the competence need (p = 0.02). Post hoc analyses showed that for both groups, competence scores were significantly higher at post-intervention (p = 0.03) and at follow-up (p = 0.04), when compared to pre-intervention scores. A significant main effect was also found for anxiety levels over time (p = 0.008). Post hoc analyses showed that for both groups, scores were significantly lower at post-intervention (p = 0.01) and at follow-up (p = 0.006), when compared to pre-intervention scores. Conclusion Although the MBI seemed useful in increasing the basic psychological need of competence and decreasing anxiety symptoms in students with severe LDs, it was not more useful than the active control intervention that was used in this project. Future studies should verify that MBIs have an added value compared to other types of interventions that can be more easily implemented in school-based settings.
Kaihekengaru: Māori Surfers' and a Sense of Place

ABSTRACT Waiti, J.T. A. and Awatere, S. , 2019. Kaihekengaru: Māori surfers' and a sense of place. In: Bryan, K.R. and Atkin, E.A. (eds.), Surf Break Management in Aotearoa New Zealand. Journal of Coastal Research, Special Issue No. 87, pp. 35-43. Coconut Creek (Florida), ISSN 0749-0208. The unique relationship that Māori have with nature and the environment is a topic that has received much interest. There is however a lack of investigation into the oceanscape, and in particular to surfing and a sense of place among Māori wave riders (Kaihekengaru). Kaihekengaru provide a unique perspective of ‘place’, as surfing involves direct engagement with nature and intimate human interactions with diverse coastal environments and peoples. This study involved an online survey and key informant interviews with Māori who regularly surf their local surfbreaks. The results suggest that for some Māori surfers a deep sense of place prevails with the environment in Aotearoa New Zealand, and that this sense of place manifests an array of thoughts and feelings related to spiritual, affective, familial, physical and cognitive perceptions. A sense of place for the participants in this study drew on Mātauranga Māori and a Māori worldview. Underpinning these experiences of place was the concept of whakapapa and its influence on environmental attachments, Ātua engagements, and ancestral connections. In a wider sense, the implications of these findings highlight the need to ensure that these oceanscapes, surfbreaks, and associated landmarks are maintained for the future benefit of all New Zealanders'.
TRPV4 Complexes With the Na+/Ca2+ Exchanger and IP3 Receptor 1 to Regulate Local Intracellular Calcium and Tracheal Tension in Mice

Intracellular Ca2+ is critical for regulating airway smooth muscle (ASM) tension. A rapid rise in the intracellular Ca2+ concentration ([Ca2+]i) of ASM cells is crucial for modulating the intensity and length of the ASM contraction. Because this rapid increase in [Ca2+]i largely depends on the balance between Ca2+ released from intracellular Ca2+ stores and extracellular Ca2+ entry, exploring the mechanisms mediating Ca2+ transport is critical for understanding ASM contractility and the pathogenesis of bronchial contraction disorders. Transient receptor potential vanilloid 4 (TRPV4) is a highly Ca2+-permeable non-selective cation channel that mediates Ca2+ influx to increase [Ca2+]i, which then directly or indirectly regulates the contraction and relaxation of ASM. The [Ca2+]i returns to basal levels through several uptake and extrusion pumps, such as the sarco(endo)plasmic reticulum Ca2+ ATPase and inositol 1,4,5-trisphosphate receptors (IP3Rs), the plasmalemmal Ca2+ ATPase, and the plasma membrane Na+/Ca2+ exchanger (NCX). Thus, to further understand ASM tension regulation in normal and diseased tissue, the present study examined whether an interaction exists among TRPV4, IP3Rs, and NCX. The TRPV4-specific and potent agonist GSK1016790A increased [Ca2+]i in mouse ASM cells, an effect that was completely blocked by the TRPV4-specific antagonist HC067047. However, GSK1016790A induced relaxation in mouse tracheal rings precontracted with carbachol in vitro. To determine the mechanism underlying this TRPV4-induced relaxation of ASM, we blocked specific downstream molecules. We found that the GSK1016790A-induced relaxation was abolished by the NCX inhibitors KB-R7943 and LiCl but not by specific inhibitors of the Ca2+-activated large-, intermediate-, or small-conductance K+ channels (BKCa, IK, and SK3, respectively). The results of co-immunoprecipitation (co-IP) assays showed an interaction of TRPV4 and IP3R1 with NCXs. Taken together, these findings support a physical and functional interaction of TRPV4 and IP3R1 with NCXs as a novel TRPV4-mediated Ca2+ signaling mechanism and suggest a potential target for regulation of ASM tension and treatment of respiratory diseases, especially tracheal spasm.
The impact of social media volume and addiction on medical student sleep quality and academic performance: A cross-sectional observational study

Problem Statement: Social media use may be detrimental to sleep quality, self-esteem, and mental health and may affect academic performance in medical students. However, the effects of problematic social media use on sleep quality and academic performance in medical students are unknown. Approach: A total of 170 medical students in a Saudi Arabian medical school were studied. The relationships between social media use volume (duration of use per day) and addiction (measured using the Bergen Facebook Addiction Scale) of seven platforms and (i) quality of sleep measured using the Pittsburgh Sleep Quality Index and (ii) academic performance according to the grade point average were examined. Caffeine intake was considered as a potential confounder, and data were analyzed using uni- and multi-variable logistic regression. Results: Poor quality sleep (72.9% and 63.5% during the week or at the weekend, respectively) and social media addiction (27.1% addicted to three or more platforms) were common. Individuals with high-volume WhatsApp (odds ratio [OR] 1.59 [1.20–2.10], P = 0.001) and Snapchat (OR 1.41 [1.10–1.81], P = 0.007) use were more likely to have very poor sleep quality at the weekend, the latter persisting in multivariable analysis. Students who were addicted to Snapchat (OR 2.53 [1.03–6.22], P = 0.044) or who were addicted to three or more social media platforms (OR 2.93 [1.19–7.23], P = 0.019) had an even greater risk of very poor weekend sleep quality. Social media addiction was not associated with academic performance. Conclusions/Recommendations: Educational programs on sleep and social media hygiene and changes to class start times to prevent weekend sleep debt should be considered.
Causes of mortality in dogs in and around Effurun/Warri Municipality of Delta State, Nigeria

This retrospective study examined death causes in hospitalized dogs in Effurun Warri region from 2002 to 2013. Over the past 12 years, out of 1,302 dogs presented with different medical conditions, 241(18.0%) were euthanized or died with a diagnostic claim for the cause of death. Proportional mortality was reported for the different categorizations. The ten most frequent causes of mortality recorded were ascites 25(10.4%), canine babesiosis 23(9.5%), cardiovascular diseases 12(5.0%), gastroenteritis 31(12.9%), canine parvoviral enteritis 47(19.5%), pneumonia 5(2.1%), snakebites envenomation 8(3.3%), toxicosis 36(14.9%) and trauma 20(8.3%) while mortalities from euthanasia and unexplained deaths accounted for 15(6.2%) and 10(4.1%), respectively. Breeds with the highest mortality rates were Alsatians 124(48.7%), Mongrels (mixed breeds) 40(16.9%), Rottweiler 21(10.8%), Indigenous dog breed 15(6.2%) and Doberman 14(5.8%). Age was significant for death causes (P<0.0001) with adult dogs having the highest mortalities 95(39.4%) followed by puppies 76(31.5%). Furthermore, more males 140(58.1%) had died compared to female dogs 101(41.9%). The result of this study revealed that preventable diseases and inadequate pet care were the primary causes of deaths in dogs in the study. This serves as a pointer to the relevance of improved management and veterinary attention to pets. Finally, the patterns of deaths in relation to gender, age and the temporal distribution for discrete causes calls for an in-depth study. Keywords: Death, Causes, Proportional mortality rate, Dog, Nigeria
Clinical utility of exhaled nitric oxide fraction in the management of asthma and COPD

Exhaled nitric oxide fraction (FENO) values can be easily measured using portable analysers and are a surrogate marker of airway eosinophilia. FENO may be useful in diagnosing and monitoring conditions characterised by airway eosinophilia, i.e. asthma and possibly COPD. Many factors other than asthma and COPD affect FENO, especially atopy, which is associated with elevated FENO. One guideline recommends that FENO should be used as part of the diagnostic pathway for asthma diagnosis in adults and children aged >5 years. The role of FENO in monitoring asthma is even less clear, and most guidelines do not recommend its use outside of specialist asthma clinics. Currently, FENO is not recommended for diagnosis or monitoring of COPD. Although FENO is starting to find a place in the management of asthma in children and adults, considerably more research is required before the potential of FENO as an objective measurement in asthma and COPD can be realised. Key points For individuals aged ≥12 years, FENO is not recommended by all guidelines as a test to diagnose asthma (recommended only by the UK National Institute for Health and Care Excellence guideline for asthma symptoms, which are likely to respond to corticosteroid treatment). FENO may be used in conjunction with other investigations to diagnose asthma in 5–16-year-olds where there is diagnostic uncertainty, but further evidence is required. FENO is not recommended as a routine test to monitor all patients with asthma or to titrate asthma treatment. FENO is not recommended for routine clinical testing in adults with COPD. FENO may be useful to identify patients with COPD who could benefit from the use of inhaled corticosteroids (asthma–COPD overlap). Educational aims To understand what factors other than asthma and COPD affect FENO To understand the current controversies in the application of FENO to diagnosis and management of asthma in children To understand the current controversies in the application of FENO to diagnosis and management of asthma and COPD in adults Exhaled nitric oxide fraction (FENO) may be a useful test for diagnosing asthma in adults and in children but is currently not recommended for monitoring all patients with asthma or COPD http://bit.ly/2lmjXpm
Awareness of predatory journals and open access among medical oncologists: results of an online survey

Introduction Predatory journals harm the integrity of science as principles of ‘good scientific practice’ are bypassed by omitting a proper peer-review process. Therefore, we aimed to explore the awareness of predatory journals among oncologists. Methods An online survey among oncologists working in Germany or Austria of various professional surroundings was conducted between October 2018 and April 2019. Results One hundred and eighty-eight participants (55 women (29.2%), 128 men (68.1%)) completed the questionnaire. 41 (21.8%) participants indicated to work in a hospital, 24 (12.8%) in private practice and 112 (59.6%) in a university hospital. 98.9% of participants indicated to actively read scientific articles and consider them in clinical decision-making (96.3%). 90.4% of participants indicated to have scientific experience by publishing papers in journals with peer-review system. The open-access system was known by 170 (90.4%), predatory journals by 131 (69.7%) and Beall’s list by 52 participants (27.7%). Predatory journals were more likely to be known by participants with a higher number of publications (p<0.001), with more high-impact publications (p=0.005) and with recent publications (p<0.001). Awareness of predatory journals did not correlate with gender (p=0.515) or translation of scientific literature into clinical practice (p=0.543). Conclusions The problematic topic of ‘predatory journals’ is still unknown by a considerable amount of oncologist, although the survey was taken in a cohort of oncologists with scientific experience. Dedicated educational initiatives are needed to raise awareness of this problem and to aid in the identification of predatory journals for the scientific oncology community.
30-Day Potentially Preventable Hospital Readmissions In Older Patients: Clinical Phenotype And Health Care Related Risk Factors

Purpose Early readmission rate has been regarded as an indicator of in-hospital and post-discharge quality of care. Evaluating the contributing factors is crucial to optimize the healthcare and target the intervention. In this study we evaluated the potential for preventing 30-day hospital readmission in a cohort of older patients and identified possible risk factors for readmission. Patients and methods Diagnosis-Related Group (DRG) codes of patients consecutively hospitalized for acute disease in the Geriatrics Unit of the University Hospital of Pisa within a 1-year window were recorded. All the patients had received a comprehensive geriatric assessment. Crossing and elaboration of the DRG codes was performed by the Potentially Preventable Readmission Grouping software (3M™ Corporation). DRG codes were classified as stand-alone admissions (SA), index admissions (IA) and potentially preventable readmissions (PPR) within a time window of 30 days after discharge. Results In total, 1263 SA and 171 IA were identified, with an overall PPR rate of 11.9%. Hospitalizations were significantly longer in IA and PPR than SA (p<0.05). The more frequent readmission causes were acute heart failure, pulmonary edema, sepsis, pneumonia and stroke. In acute heart failure a nonlinear U-shaped readmission trend (with nadir at 5 days of hospitalization) was observed while, in all the other DRG codes, the PPR rate increased with increasing length of hospitalization. Comprehensive geriatric assessment showed a significantly lower degree of disability and comorbidity in SA than IA patients. At stepwise regression analysis, a high degree of disability and comorbidity as well as the diagnosis of sepsis emerged as independent risk factors for PPR. Conclusion Addressing PPR is crucial, especially in older patients. The adequacy of treatment during hospitalization (especially in cases of sepsis) as well as the setting of a comprehensive discharge plan, accounting for comorbidity and disability of the patients, are essential to reduce PPR.
RNA m 6 A Methyltransferase METTL3 Promotes The Growth Of Prostate Cancer By Regulating Hedgehog Pathway

Purpose: N 6 -methyladenosine (m 6 A) is the most abundant internal modi ﬁ cation on eukar-yotic mRNA and gained increasing attention recently. More and more evidence suggest that m 6 A methylation plays crucial role in tumor genesis and development. However, its role in prostate cancer remains largely unknown. Methods: METTL3 expression status in prostate cancer was analyzed by using TCGA database and Western blotting. m 6 A content was analyzed by using RNA Methylation Quanti ﬁ cation Kit. The role of METTL3 in prostate cancer cells was determined by proliferation, survival, colony formation, and invasion assays. The m 6 A level of GLI1 RNA was detected by methylated RNA immunoprecipitation (MeRIP) assay. In vivo role of METTL3 was studied on xenograft models. Results: We found that m 6 A methyltransferase METTL3 was overexpressed in prostate cancer cell lines, together with increased m 6 A content. Functionally, silencing of METTL3 by shRNA in prostate cancer cell lines resulted in decreased m 6 A content, cell proliferation, survival, colony formation, and invasion. Interestingly, overexpression of wild-type METTL3 abrogated the repression effect of METTL3 depletion on m 6 A content, cell proliferation, survival, colony formation, and invasion, while the overexpression of m 6 A catalytic site mutant METTL3 was unable to rescue the inhibitory effect caused by METTL3 depletion. Further mechanism analysis demonstrated that METTL3 silence decreased the m 6 A modi ﬁ cation and expression of GLI1, an important component of hedgehog pathway, which led to cell apoptosis. Moreover, depletion of METTL3 inhibited tumor growth in vivo. Conclusion: Our results suggested that the m 6 A methyltransferase METTL3 promotes the growth and motility of prostate cancer cells by regulating hedgehog pathway.
A Comparative Study between Walking and Outdoor Cycling As an Exercise Modality of Preference amongst Obese Women

Objective: This study was intended to evaluate perception of the young adult obese women towards outdoor cycling (henceforth referred to as –cycling) as a proper and useful modality as compared to walking. Study Design: The study, a questionnaire based, was conducted in a weight management clinic in Maharashtra state, India. Obese women between 18 - 40 years of age during their first visit were studied for their perception about cycling Results: There was no significant difference between the scores with walking and cycling indicating these as proper and useful modalities of exercise Conclusions: Our results clearly indicate that cycling is perceived to be an equally proper and useful modality of exercise as compared with walking amongst obese women . Further studies using larger sample size must be conducted.
Sex-Based Differences in Patient-Reported Outcomes After Arthroscopic Rotator Cuff Repair

Background: Rotator cuff repair is one of the most common surgical procedures performed on the shoulder. Previous studies have indicated that pain and disability can vary significantly between patients with similarly appearing rotator cuff tears on diagnostic imaging. Prior literature has compared functional outcomes between operative and nonoperative treatments as well as variability in surgical techniques. However, few studies have examined postoperative outcomes based on patient factors such as sex. Purpose: To compare patient-reported outcomes after rotator cuff repair between men and women. Study Design: Cohort study; Level of evidence, 2. Methods: A total of 283 patients (153 male, 130 female) who underwent primary arthroscopic rotator cuff repair were included in this study; of those, 275 patients (97.2%) completed 1-year follow-up. Patient-reported pain visual analog scale (VAS), Veterans RAND 12-item Health Survey (VR-12 mental and physical components), American Shoulder and Elbow Surgeons (ASES), and Single Assessment Numeric Evaluation (SANE) scores were collected preoperatively and at 2 weeks, 6 weeks, 3 months, 6 months, and 1 year postoperatively using an electronic outcomes system. Results: Women reported higher VAS pain scores when compared with men preoperatively (P < .01) and at 2 weeks (P < .01), 6 weeks (P < .01), and 3 months (P = .02) postoperatively. Additionally, women experienced a greater overall change in the mean VAS score preoperatively when compared with 1 year postoperatively (P < .01). The use of narcotic pain medication 2 weeks after surgery was greater in women (P = .032). Women had significantly lower preoperative VR-12 mental scores (P = .03) and experienced a greater increase in the mean VR-12 mental score preoperatively when compared with 1 year postoperatively (P < .01). Men had higher ASES scores preoperatively (P < .01) and at 3 months postoperatively (P < .01). Women experienced a greater overall change in the ASES score preoperatively when compared with 1 year postoperatively (P < .01). Conclusion: Women reported greater pain and decreased shoulder function compared with men during the initial 3 months after arthroscopic rotator cuff repair. There were no sex-based differences in patient-reported outcomes at 1-year follow-up. The results of this study indicate that there are sex-related differences in the early postoperative recovery of patients undergoing rotator cuff repair, contributing to postoperative expectations for both clinicians and patients alike.
miR-1305 Inhibits The Progression Of Non-Small Cell Lung Cancer By Regulating MDM2

Background Increasing evidence has suggested the critical implication of microRNAs (miRNAs) in the initiation and progression of non-small cell lung cancer (NSCLC). Previous studies have shown the tumor-suppressive function of miR-1305 in cancer; however, the role of miR-1305 in NSCLC has not been fully understood. Methods The expression of miR-1305 in NSCLC was detected by RT-qPCR. The influence of miR-1305 on the growth of NSCLC cells was determined via Cell Counting Kit 8 (CCK-8), colony formation and FACS analysis. The targets of miR-1305 were predicted with the miRDB database. Luciferase reporter assay was performed to investigate the binding between miR-1305 and 3ʹ-UTR of MDM2. Western blot was applied to check the expression of MDM2 with miR-1305. Results Here, we found that miR-1305 was down-regulated in NSCLC tissues and cell lines. Decreased miR-1305 was significantly correlated with the metastasis and poor prognostics of NSCLC patients. Overexpression of miR-1305 inhibited the proliferation and migration and promoted the apoptosis of NSCLC cells. Bioinformatics and luciferase assay uncovered that the mouse/murine double minute 2 (MDM2) was a target of miR-1305. miR-1305 bound the 3ʹ-untranslated region (UTR) of MDM2 and decreased the expression of MDM2 in NSCLC cells. As MDM2 was a negative regulator of p53, decreased MDM2 by miR-1305 up-regulated the abundance of p53 in NSCLC cells. Restoration of MDM2 markedly attenuated the suppressive role of miR-1305 in the proliferation and migration of NSCLC cells. Conclusion The findings provided novel mechanism of miR-1305/MDM2 signaling in regulating the progression of NSCLC, suggesting miR-1305 as a promising target for the treatment of NSCLC.