Miracle-dz/UniFAR-FTUs huggingface dataset:
Patients With Uncomplicated Coronavirus Disease 2019 (COVID-19) Have Long-Term Persistent Symptoms and Functional Impairment Similar to Patients with Severe COVID-19: A Cautionary Tale During a Global Pandemic

To assess the prevalence of persistent functional impairment after coronavirus disease (COVID-19), we assessed 118 in-dividuals 3–4 months after their initial COVID-19 diagnosis with a symptom survey, work productivity and activity index questionnaire, and 6-minute walk test. We found significant persistent symptoms and functional impairment, even in non-hospitalized patients with COVID-19.
Interlaboratory comparison of delta C-13 and delta D measurements of atmospheric CH4 for combined use of data sets from different laboratories

We report results from a worldwide interlaboratory comparison of samples among laboratories that measure (or measured) stable carbon and hydrogen isotope ratios of atmospheric CH 4 ( δ 13 C-CH 4 and δ D-CH 4 ) . The offsets among the laboratories are larger than the measurement reproducibility of individual laboratories. To disentangle plausible measurement offsets, we evaluated and critically assessed a large number of intercomparison results, some of which have been documented previously in the literature. The results indicate signiﬁcant offsets of δ 13 C-CH 4 and δ D-CH 4 measurements among data sets reported from different laboratories; the differences among laboratories at modern atmospheric CH 4 level spread over ranges of 0.5 ‰ for δ 13 C-CH 4 and 13 ‰ for δ D-CH 4 . The intercomparison results summarized in this study may be of help in future attempts to harmonize δ 13 C-CH 4 and δ D-CH 4 data sets from Published by Copernicus Publications on behalf of the European Geosciences Union.
A Study on Visualization of User Reviews

—User reviews is a research method with increasing application in the application (‘app’) industry in recent years because it allows development teams to better understand users’ needs and ideas through user review analysis. However, deciding how to interpret the massive daily incoming user review data and how to sort them into useful information is a challenge that development teams must address. This study combined the architecture of an app with the excellent information communication capability of information visualisation and compiled a priority list of version releases based on function areas mentioned in user reviews, allowing development teams to create strategies for updates and emergency resolution, as well as designing apps to meet users’ expectations, and to therefore achieve better user experience. Subsequent to a heuristic evaluation, the three most important suggestions were made: 1. Improve the enrichment of the visualisation chart; 2. Increase follow-up evaluation; and 3. Understand the reasons and context that lead users to like apps. Experts that participated in the evaluation believed that the visualisation chart generated in this study allows developers to better understand users’ real needs, to be able to focus on the more serious issues related to system structure, and assign them with higher priority for repair such that product evaluation will be enhanced resulting in more download volume and profits. The experts also believed that if visualisation charts can be enhanced with more flexibility and user reviews will be followed up with ongoing evaluation, the approach suggested in the present study will surely prove to be very useful in the app market application.
Regulation of Lipopolysaccharide-Induced Inducible Nitric-Oxide Synthase Expression through the Nuclear Factor- (cid:1) B Pathway and Interferon- (cid:2) /Tyrosine Kinase 2/Janus Tyrosine Kinase 2-Signal Transducer and Activator of Transcription-1 Signaling Cascades by 2-Naphthylethyl-6,7-dihydroxy-

The effects of 2-naphthylethyl-6,7-dihydroxy-1,2,3,4-tetrahy- droisoquinoline (THI 53), on nitric oxide (NO) production and inducible nitric-oxide synthase (iNOS) protein induction by lipopoly- saccharide (LPS) were investigated in RAW 264.7 cells and mice. In cells, THI 53 concentration dependently reduced NO produc- tion and iNOS protein induction by LPS. In addition, THI 53 inhibited NO production and iNOS protein induction in LPS-treated mice. LPS-mediated iNOS protein induction was inhibited significantly by the specific tyrosine kinase inhibitor (cid:3) -cyano-(3-hy-droxy-4-nitro)cinnamonitrile
JAMIA Focus on E-health: Electronic Interactions with Patients Automated E-mail Messaging as a Tool for Improving Quit Rates in an Internet Smoking Cessation Intervention

Objective: The aim of this study was to determine whether an automated e-mail messaging system that sent individually timed educational messages (ITEMs) increased the effectiveness of an Internet smoking cessation intervention. Design: Using two consecutive series of participants, the authors compared two Web-based self-help style smoking cessation interventions: a single-point-in-time educational intervention and an enhanced intervention that also sent ITEMs timed to participants’ quit efforts. Outcomes were compared in 199 participants receiving the one-time intervention and 286 receiving ITEMs. Measurements: Demographic factors, number of cigarettes smoked, nicotine addiction, depressive symptoms, and conﬁdence in ability to quit were measured at entry. Twenty-four–hour quit attempts and seven-day point-prevalence of abstinence (nonrespondents assumed to smoke) were measured 30 days after each subject’s self-selected quit date. Results: The one-time and ITEMs groups differed in some demographics and some relapse risk factors but not in factors associated with 30-day quit rates. ITEMs appeared to increase the rate at which individuals set quit dates (97% vs. 91%, p = 0.005) and, among the respondents to follow-up questionnaires ( n = 145), the rate of reported 24-hour quit efforts (83% vs. 54%, p = 0.001). The 30-day intent-to-treat quit rates were higher in the ITEMs group: 7.5% vs. 13.6%, p = 0.035. In multivariate analyses controlling for differences between groups, receiving ITEMs was associated with an increase in the odds ratio for quitting of 2.6 (95% conﬁdence interval = 1.3–5.3). Conclusion: ITEMs sent on strategic days in smokers’ quit efforts enhanced early success with smoking cessation relative to a single-point-in-time Web intervention. The effect
Journal of Food & Nutritional Disorders Role of pH in the Mutagenicity of Aflatoxin B1 in Maize Tortillas during In Vitro Human Digestion Model

Introduction: Aflatoxins (AFs) are potent mutagens, carcinogens and teratogens for humans; thus their presence in food is of great concern. A maize tortilla survey in Mexico revealed that 17% are contaminated with AFs. The initial process to prepare tortillas includes boiling maize grains with lime and to assumpt that AFs in maize tortillas are destroyed, protecting consumers from their mutagenic effects. Objective: The purpose of this study was to investigate the mutagenicity of aflatoxin B1 (AFB1) in tortillas during digestion. Methods: Two in vitro models of human digestion were used: one with maize naturally contaminated by AFB1, and another with AFB1 standard spiked to them. The pH at each step was measured, and a neutral pH range (5.8 to 7.5) reactivated the AFB1 mutagenicity. AFB1 was quantified by HPLC, and its mutagenicity was determined by Ames test. Human digestion treatments were saliva (pH 7.0), artificial gastric juice with pepsin (pH 1.2), pancreatic fluid with pancreatin (pH 7.5) and combinations of saliva with gastric juice (pH 1.8), gastric and pancreatic fluids (pH 2.4), and saliva with gastric and pancreatic fluids (pH 5.8). Results: The alkalinity of the lime treatment (pH 12.0) and the acidity of gastric fluid (pH 1.2) inhibited AFB1 mutagenicity. The neutral pH of saliva increased mutagenicity, and of pancreatic fluid returned the mutagenicity to untreated levels. The mixture of saliva with gastric and pancreatic fluids (pH 5.8) also rendered the AFB1 mutagenic. Conclusion: The pH during human digestion plays an important role in the mutagenicity of AFB1.
THE SEMANTIC GAME OF THE VERB LLEVAR : AN ANALYSIS OF SPANISH LANGUAGE SITES HEADLINES

: This paper aims to discuss the semantic categories of the verb llevar from sentences taken from electronic newspapers. Presented with different meanings, the sentences highlighted for the analysis of this work present metaphorical meanings with different meanings for different contexts. Therefore, the texts were analyzed based on the application of the cultural, grammatical, and conceptual semantic categories, according to the approach of Moura (2006) and Lakoff and Johnson (1980; 2002). At the end of the study, it was noticed that the semantic variations resulting from the use of the llevar verb vary according to the context of use, as well as the meanings made possible in syntactic constructions surpass a superficial level of understanding of the interlocutor: the verb polysemy and the context of its utterance interfere with its accomplishment and the senses uttered.
Inﬂammatory Effects of Edwardsiella ictaluri Lipopolysaccharide Modiﬁcations in Catﬁsh Gut

Bacterial lipopolysaccharides (LPS) are structural components of the outer membranes of Gram-negative bacteria and also are potent inducers of inﬂammation in mammals. Higher vertebrates are extremely sensitive to LPS, but lower vertebrates, like ﬁsh, are resistant to their systemic toxic effects. However, the effects of LPS on the ﬁsh intestinal mucosa remain unknown. Edwardsiella ictaluri is a primitive member of the Enterobacteriaceae family that causes enteric septicemia in channel catﬁsh ( Ictalurus punctatus ). E. ictaluri infects and colonizes deep lymphoid tissues upon oral or immersion infection. Both gut and olfactory organs are the primary sites of invasion. At the systemic level, E. ictaluri pathogenesis is relatively well characterized, but our knowledge about E. ictaluri intestinal interaction is limited. Recently, we observed that E. ictaluri oligo-polysaccharide (O-PS) LPS mutants have differential effects on the intestinal epithelia of orally inoculated catﬁsh. Here we evaluate the effects of E. ictaluri O-PS LPS mutants by using a novel catﬁsh intestinal loop model and compare it to the rabbit ileal loop model inoculated with Salmonella enterica serovar Typhimurium LPS. We found evident differences in rabbit ileal loop and catﬁsh ileal loop responses to E. ictaluri and S . Typhimurium LPS. We determined that catﬁsh respond to E. ictaluri LPS but not to S . Typhimurium LPS. We also determined that E. ictaluri inhibits cytokine production and induces disruption of the intestinal ﬁsh epithelia in an O-PS-dependent fashion. The E. ictaluri wild type and (cid:2) wibT LPS mutant caused intestinal tissue damage and inhibited proinﬂammatory cytokine synthesis, in contrast to E. ictaluri (cid:2) gne and (cid:2) ugd LPS mutants. We concluded that the E. ictaluri O-PS subunits play a major role during pathogenesis, since they inﬂuence the recognition of the LPS by the intestinal mucosal immune system of the catﬁsh. The LPS structure of E. ictaluri mutants is needed to understand the mechanism of interaction.
OPTH_A_243203 775..793

Rosanna Dammacco 1 Giovanni Alessio 1 Ermete Giancipoli 2 Patrizia Leone 3 Anna Cirulli Leonardo Resta 4 Angelo Vacca 3 Franco Dammacco 3 1Department of Ophthalmology and Neuroscience, University of Bari “Aldo Moro”, Medical School, Bari, Italy; 2Department of Biomedical Sciences, Ophthalmology Unit, University of Sassari, Sassari, Italy; 3Department of Biomedical Sciences and Human Oncology, University of Bari “Aldo Moro”, Medical School, Bari, Italy; 4Department of Emergency and Organ Transplantation, University of Bari “Aldo Moro”, Medical School, Bari, Italy Purpose: Giant cell arteritis (GCA), a chronic vasculitis of the large and medium-sized arteries, affects people >50 years of age. This study assessed the prevalence of visual manifestations and other clinical features at presentation in an Italian cohort of GCA patients. Recent advances in the pathophysiology, diagnosis, and therapy of GCA are also reviewed. Methods: This retrospective, single-center study conducted by the ophthalmology and internal medicine clinics of one university recruited 56 patients from 2005 to 2016 and followed them for 11–54 months. Results: Ocular involvement was diagnosed in 19 patients (33.9%), with permanent vision loss in 19.6% (7.1% of the cohort with bilateral vision loss). Arteritic anterior and posterior ischemic optic neuropathy were diagnosed in 11 patients (57.9%) and 1 patient (5.3%), respectively, cotton wool spots in 3 patients (15.8%), central retinal artery occlusion in 2 patients (10.5%), and anterior segment ischemia and multifocal choroidal ischemia in 1 patient each (5.3%). Polymyalgia rheumatica was associated with GCA in 44.6% of the patients. The most common extra-ocular manifestation was constitutional symptoms (82.1% of the patients). Large-vessel involvement, including of the ascending aorta, aortic arch, and left axillary artery, was diagnosed by magnetic resonance or computed tomography (CT) angiography and FDG positron emission/CT. Glucocorticoids (GCs) remain the standard-of -care worldwide, but methotrexate, provided as a steroid-sparing drug in 41% of the patients, resulted in earlier tapering, a lower cumulative dose of GCs, and a lower rate of relapse. Among the combinations of GCs and immunosuppressive drugs proposed to treat GCA, only tocilizumab has effectively induced and maintained disease remission. Conclusion: According to our data and literature reports: a) GCA is a systemic disease; b) its diagnosis is expedited by the adjunct use of imaging techniques; c) insights into the pathogenesis of GCA may allow an improved, differentiated therapeutic approach.
Study of Indian Population -- Lumbar Canal Diameter Evaluation by CT Morphometry

Study Design: A cross-sectional study. Background: To document dimensions of the lumbar vertebrae and bony canal in an Indian population and to compare with other studies from the subcontinent as well as from other parts of world. Methods: An observational study was conducted on the basis of a review of thin-cut (3 mm) computed tomographic images of lumbar vertebrae. A total of 302 patients were studied, and various dimensions were analyzed. Results: In general, the vertebral and bony spinal canal dimensions were found to be greater in male patients. Comparison of populations revealed statistically significant differences in the spinal canal between an Indian population and others. Overview of Literature: Lumbar canal stenosis is a condition in which the anteroposterior and lateral dimensions of the bony spinal canal are less than normal for corresponding age and sex. Numerous studies have been conducted to determine morphometry of the lumbar vertebrae and spinal canal, mostly in western populations, using fresh cadaver or osteologic specimens. These studies did not mention the difference between the vertebral parameters in men and women. Moreover, many of these studies have limitations such as a small sample size and lack of demographic data including race, age, and sex. In this study, we have conducted morphometric analysis of the lumbar vertebrae in a relatively large number of Indian patients by using computed tomography scan. The morphometric data thus compiled may provide a baseline of body and canal dimensions that could guide clinical experts in their practice. Conclusions: The dimensions of the lumbar vertebrae and bony canal thus obtained shall provide a baseline normative data for evaluation of patients presenting with low backache and lumbar canal in an Indian population.
(cid:2) -Aminobutyric Acid Type B Receptor-mediated Signaling by Inhibition of the Interaction of (cid:2) -Aminobutyric Acid Type B Receptors with G Protein– coupled Receptor Kinase 4 or 5

Background: Intrathecal baclofen therapy is an established treatment for severe spasticity. However, long-term management occasionally results in the development of tolerance. One of the mechanisms of tolerance is desensitization of (cid:1) -aminobutyric acid type B receptor (GABA B R) because of the complex formation of the GABA B2 subunit (GB 2 R) and G protein–coupled receptor kinase (GRK) 4 or 5. The current study focused on S ( (cid:1) )-ketamine, which reduces the development of morphine tolerance. This study was designed to investigate whether S ( (cid:1) )-ketamine affects the GABA B R desensitization processes by baclofen. Methods: The G protein–activated inwardly rectifying K (cid:1) channel currents induced by baclofen were recorded using Xenopus oocytes coexpressing G protein–activated inwardly rectifying K (cid:1) channel 1/2, GABA B1a receptor subunit, GB 2 R, and GRK. Translocation of GRKs 4 and 5 and protein complex formation of GB 2 R with GRKs were analyzed by confocal microscopy and fluorescence resonance energy transfer analysis in baby hamster kidney cells coexpressing GABA B1a receptor subunit,
Does Foreign Banks Entry Influence Domestic Banks' Efficiency? Evidence from Ghana

The study investigates the effect of foreign bank entry on the efficiency of domestic banks in Ghana. The study applies the Stochastic Frontier Analysis (SFA) technique and the system Generalized Method of Moments (GMM) estimator on bank specific level data, spanning the period 2000 to 2015. The results show that foreign banks with an average profit efficiency of 74.7% are more profit efficient than domestic banks with a score of 71% which conforms to the global advantage hypothesis. This suggests that foreign banks are able to maximize revenue through the generation of interest income on loans and investments better than domestic banks due to the foreign banks' comparative advantage in terms of international expertise. Further, the system GMM results indicate that the entry of foreign banks has contributed to the profit efficiency of domestic banks in Ghana. This positive spillover effect of foreign banks is manifested in their transfer of international expertise, technological knowledge, quality banking services and competitive pressure to domestic banks. In addition, bank size and liquidity are essential determinants of the profit efficiency of domestic banks in Ghana. The findings of the study imply that bank regulators in developing countries should push for reforms that eliminate implicit and explicit barriers that may hinder the entry of foreign or new banks.
Measurement of ArylsulfataseA Activity in Urine1

SubmitLynn E. Posey, Department of Pathology, ters: Louisiana State University Medical Center, New Orleans, LA 70112 Lee Roy Morgan, Jr., Departments of Pharmacology and Medicine, Louisiana State University Medical Center, New Orleans, LA 70112 EvaluaSam Levin, Inst itut Jules Bordet, Centre tors: des Tumeurs de L’Universit#{233}Libre de Bruxelles, Bruxelles, Belgium Morton K. Schwartz, Memorial-Sloan Kettering Cancer Center, New York, NY 10021
Radial anisotropy and prior constraints: A comparative study

[ 1 ] Radial seismic anisotropy models are traditionally obtained using empirical constraints based on laboratory experiments and petrological considerations. We tested the hypothesis that such petrological constraints affect the uppermost mantle models of S wave anisotropy using a statistical approach. In addition, we were able to determine which model features are constrained by the data and which are dominated by the prior. We focused on large-scale models and found that the most likely models obtained in both cases are highly correlated. This demonstrates that for the best data-fitting solution, the geometry of uppermost mantle radial anisotropy is not strongly affected by prior petrological constraints. The amplitude of the anomalies, however, can change significantly: The best data-fitting model obtained without petrological constraints displays stronger amplitudes than the one obtained with prior. This could become an issue when quantitatively interpreting seismic anisotropy models, and thus emphasizes the importance of accurately accounting for parameter uncertainties and trade-offs, and of understanding whether the seismic data or the prior constraints the model. We showed that model uncertainties are strongly affected by the prior as the relative RMS uncertainties were reduced by a factor of 2. In addition, we showed that while the model distributions are not necessarily Gaussian a priori, imposing petrological constraints can force the distributions to be narrower and more Gaussian-like, as expected from inverse theory. Finally, we demonstrated that the age dependence of seismic wave velocities is robust and independent of prior constraints. A similar age signal exists for anisotropy, but with larger uncertainties without prior constraints.
Self-Control and Social Pressure an Important Determinant on The Saving Behaviour Among University’ Students

For decades, many researchers have investigated the determinants of individual’ saving behavior of household and employees but not many on the young individuals such as students in the universities. Despite that, not many studies studied financial behavior of students in the university, the majority of studies did not drive by theory, and focused on one single factors only. Purpose: Therefore, this study aimed to explore and investigate the influence of self-control, social pressure and knowledge in financial management on the saving behavior among Malaysian students’ university by applying Planned Behavior Theory. Methodology : the research strategy for this study was survey questionnaire for collecting the primary data. The samples size comprised 340 students from University Utara Malaysia using sample random sampling technique. Descriptive, goodness of the measurements and model validation Parametric test (ANOVA) were used to analysis the saving behaviour scores of the respondents by SPSS 24 th . The result : shows that there are positive relation for self-control, social pressure and knowledge in financial management on saving behavior while the greatest impact on saving behavior was the social pressure. For practical implication, retail banks can use this research contribution to design effective strategies in order to penetrate the saving behavior of university’ young students. Besides that, it also lightens the policy’ makers in the university and government to encourage saving among the university’ students. Also, provides the parents with insights explanation to ensure foster a sound saving behavior for their children.