Miracle-dz/UniFAR-FTUs huggingface dataset:
Evaluation of HER2Neu Status in Periampullary Cancers in Tertiary Care Centre in Northern India: A Three-Year Retrospective Study

Background Periampullary carcinoma is a heterogeneous group of malignancies, and despite advances in treatment, its mortality rate remains high. A better understanding of the disease and factors influencing its course and potential therapeutic targets is imperative for improving its overall outcome. Through comprehensive cytogenetic analysis, it has been established that the development of periampullary carcinogenesis involves specific chromosomal aberrations, dysregulation of oncogenes, and suppression of genes in a multistep progressive manner. Our study aimed to evaluate the expression of human epidermal growth factor (HER2Neu) in periampullary cancers using immunohistochemistry and fluorescent in situ hybridization. Material and methods This was a retrospective study in which all consecutive cases of periampullary carcinoma diagnosed over a period of three years were evaluated. HER2neu expression was analyzed using immunohistochemistry (IHC) and fluorescent in-situ hybridization (FISH). Histopathological evaluation was performed according to the College of American Pathologists (CAP) protocol. Results Twenty patients were diagnosed during the study period. On histomorphologic analysis, most cases (n=17) were diagnosed as well-differentiated adenocarcinomas, the most common subsite being the ampulla of Vater and pathological staging as pT2N0Mx. On IHC, no overexpression of HER2Neu was reported in any case, but FISH analysis revealed one point of amplification with HER/centromere enumerator probe (CEP) ratio>2. Conclusion HER2Neu evaluation in periampullary carcinoma has limited value; thus, it could have a restricted therapeutic role.
Anatomy of a diffuse cryptic suture zone: An example from the Bohemian Massif, European Variscides

The fate of the lower plate during continental collision can be examined in deeply eroded orogens such as the late Paleozoic Variscan belt in continental Europe. In particular, the Bohemian Massif at its eastern extremity preserves well the evolution of an Andean-type orogen involved in continental collision. This process included relamination of subducted light felsic material rich in radioactive elements underneath a dense mafic lower crust of the upper plate. This led to gravity-driven overturns and overprinting of the original suture by a broad zone of mixed upper and lower plate materials. In the studied example, this zone of interaction repeatedly reappears within the orogen, forming a so-called “diffuse cryptic suture zone. ”
Surface Albedo of the Antarctic Sea Ice Zone

In three ship-based field experiments, spectral albedos were measured at ultraviolet, visible, and nearinfrared wavelengths for open water, grease ice, nilas, young “grey” ice, young grey-white ice, and first-year ice, both with and without snow cover. From the spectral measurements, broadband albedos are computed for clear and cloudy sky, for the total solar spectrum as well as for visible and near-infrared bands used in climate models, and for Advanced Very High Resolution Radiometer (AVHRR) solar channels. The all-wave albedos vary from 0.07 for open water to 0.87 for thick snow-covered ice under cloud. The frequency distribution of ice types and snow coverage in all seasons is available from the project on Antarctic Sea Ice Processes and Climate (ASPeCt). The ASPeCt dataset contains routine hourly visual observations of sea ice from research and supply ships of several nations using a standard protocol. Ten thousand of these observations, separated by a minimum of 6 nautical miles along voyage tracks, are used together with the measured albedos for each ice type to assign an albedo to each visual observation, resulting in “ice-only” albedos as a function of latitude for each of five longitudinal sectors around Antarctica, for each of the four seasons. These ice albedos are combined with 13 yr of ice concentration estimates from satellite passive microwave measurements to obtain the geographical and seasonal variation of average surface albedo. Most of the Antarctic sea ice is snow covered, even in summer, so the main determinant of area-averaged albedo is the fraction of open water within the pack.
Geochemistry and petrogenesis of Early Cretaceous alkaline igneous rocks in Central Europe: Implications for a long-lived EAR-type mantle component beneath Europe

In Central Europe, Early Cretaceous alkaline igneous rocks (lamprophyres, basanites, phonolites) occur in the Moravian-Silesian Beskidy area (northern Czech Republic and southern Poland) and in the Mecsek-Alfold Zone (southern Hungary). Presently they are located at about 400 km distance of each other. These alkaline igneous rocks show close similarities in their mineral, chemical, and bulk rock compositional data, implying similar petrogenesis and suggesting that these two regions could have been much closer during the Early Cretaceous; they could belong to the same rift zone in the European continental margin. Their trace element distribution and Sr and Nd isotopic ratios suggest that the parental magmas derived from an enriched, HIMU OIB-like asthenospheric mantle by different degrees (3-6%) of partial melting at the depth of spinel-garnet transitional and garnet stabilization zone (about 60-80 km depth). This mantle source appears to be akin to that thought to have supplied the Tertiary to Quaternary .
Audiovisual-Based Jigsaw Method in Post-COVID-19 to Increase Students' Capacity in Indonesia

Recovery of learning after the Covid-19 pandemic requires all stakeholders to innovate inclusive and quality learning as an option to mitigate learning loss towards learning in the new normal era. Hybrid learning is an alternative learning towards a transitional period in the form of a mix between online and offline learning. This research is to measure the effectiveness of the audiovisual-based jigsaw method in the hybrid learning process to increase the capacity of junior high school students to write scientific papers in Maros Regency, Indonesia. The research was using a descriptive-qualitative approach, namely exploring the learning situation through the application of the J-AV method to measure the students’ capacity of scientific papers and the ability to work together in groups. This research found an empirical fact that students were able to significantly increase their capacity to write scientific papers through the jigsaw learning method using audiovisual media on aspects of format, writing, presentation, analysis, synthesis and conclusion. Before using audiovisual media, the average score of students’ scientific papers was 71 with a quality of C or medium, but by using audiovisual media in compiling scientific papers, they could increase their average score to be 84 with B or good quality.
Modal and Static Analysis of Vortex Bladeless Wind Turbines with Different Geometries

The renewable energy industry has undergone remarkable growth in recent times, with wind energy assuming a preeminent role as a source of clean energy. Five distinctive geometries were analyzed, including a traditional circular form, a decagonal form, and three sinusoidal forms to evaluate the modal and structural characteristics of vortex bladeless wind turbines. The ANSYS software was employed to carry out both the modal and structural analysis. The vortex bladeless rod was firmly fixed and the mast was exposed to a wind pressure of 15 Pa during modal analysis. The structural analysis was executed to compute the deflection of the vortex bladeless wind turbine under the same wind pressure. The results demonstrated that the sinusoidal forms exhibited the greatest deflection at a wind speed of 5m/s. These findings possess the potential to optimize and augment the design of vortex bladeless wind turbines, provide guidance for future design decisions, and boost the efficiency and dependability of these wind turbines. It is therefore posited that the consideration of diverse geometries in the design of vortex bladeless wind turbines is of paramount importance, and the findings of this study are expected to be of great use to engineers and designers in the wind energy field, thereby catalyzing the progression of this thriving renewable energy source.
Sigmoid models in the description of CO₂ evolved from legumes in the soil

The decomposition of legumes in the soil over time can be described by nonlinear sigmoid models. Thus, this study aimedto describe and to compare the fit of the nonlinear sigmoid models, Logistic and Gompertz, to the CO2 mineralization of fourlegume species over time in the soil, and indicate the most suitable model. Furthermore, it is also proposed to evaluate the CO2mineralization of legumes from two different edaphoclimatic conditions when added to the soil under controlled temperatureand humidity conditions. The following legume species used in green manure were evaluated: Arachis pintoi (forage peanut),Calopogonium mucunoides (calopo), Stylosanthes guianensis (Caribbean stylo), and Stizolobium aterrimum (mucuna). Arandomized block design with four replications was used. The soils from both areas are classified as Red-Yellow Latosol andhave a clayey texture. The mineralized carbon was measured at 48, 96, 144, 192, 240, 312, 384, and 480 hours fromthe beginning of incubation. Legumes in different locations had the same amount of potentially mineralizable carbon, andmicroorganisms had the same adaptation time to reach the maximum decomposition rate. The maximum decompositionrate occurs at the beginning of mineralization, and therefore the Gompertz model was more suitable than the Logistic modelin describing the decomposition of the four legumes in the soil.
Does the Lunar Cycle Affect Birth and Deaths

There is a commonplace notion that full moons affect natality and mortality. To test this theory, we obtain daily births and deaths data from Australia, covering all 10,592 days from 1 January 1975 to 31 December 2003. We find that full moons are not associated with any significant change in the number of conceptions, births, or deaths. Moreover, our standard errors are sufficiently tight to make it possible to rule out even modest positive or negative effects of the lunar cycle.
Hyporheic exchange of solutes and colloids with moving bed forms

Stream‐subsurface exchange provides the opportunity for stream‐borne substances to interact with streambed sediments in the subsurface hyporheic mixing zone. The downstream transport of both solutes and colloids can be substantially affected by this exchange, with significant implications for contaminant transport and stream ecology. Several previous studies have demonstrated that bed form–induced advective flows (pumping) and scour/deposition of bed sediments (turnover) will often be the dominant processes controlling local exchange with the streambed. A new model is presented for combined turnover and pumping exchange due to relatively fast‐moving bed forms, i.e., when turnover dominates the exchange in the upper part of the bed where active bed sediment transport occurs. While turnover rapidly mixes the upper layer of the bed, advective pumping produces exchange with the deeper, unsecured region of the subsurface. The net exchange due to these processes was analyzed using fundamental hydraulic principles: the initial exchange was calculated using an existing geometric model for turnover, and then the later exchange was determined by analyzing the advective flow induced under the moving bed form field. The exchange of colloidal particles due to moving bed forms was also modeled by considering the further effects of particle settling and filtration in the subsurface. Experiments were conducted in a recirculating flume to evaluate solute (conservative Li+) and colloid (kaolinite) exchange with a sand bed. The solute and colloid exchange models performed well for fast‐moving bed forms, but underpredicted the colloid exchanges observed with lower rates of bed sediment transport. For very slowly moving bed forms it was found that turnover could be completely neglected, and observed colloid exchanges were represented well by a pure pumping model. In the intermediate case where turnover and pumping rates are similar, water carried into the bed by turnover is immediately released by pumping, and vice versa. Thus, while this work further elucidated the basic processes controlling solute and colloid exchange with a bed covered by bed forms and provided a fundamental model for exchange due to fast‐moving bed forms, exchange in the intermediate case where turnover and pumping tend to compete can only be bounded by current models.
Assessing red spruce (Picea rubens Sarg.) restoration potential under current and future predicted climate change in Virginia

Global climate change threatens many species across the planet. High‐elevation species, such as red spruce (Picea rubens), face significant and immediate threats from climate change. Red spruce has faced anthropogenic disturbances for over a century and is only recently beginning to recover across its range. Ecological niche modeling has become a common method of identifying the suitable habitat of a species, providing vital information to land managers carrying out restoration efforts. In this study, ecological niche models were used in a novel way, predicting distribution and habitat suitability separately and simultaneously to determine the spatial extent to which red spruce forests can be restored. In addition to models, surveys were conducted to elucidate the current regeneration trends of red spruce. Furthermore, climate projections were used to determine how restoration potential may change over the course of the twenty‐first century. Comparisons between distribution and habitat suitability models indicate that there is additional habitat available for red spruce expansion. Regeneration surveys show that there is positive regeneration both within and beyond red spruce canopies, validating model comparisons. Climate change projections indicate total elimination of suitable habitat in Virginia by 2100. However, these projections likely predict increased competition for red spruce from low elevation competitors as opposed to physiological limitations imposed by climate change. It is therefore prudent to protect established populations and encourage further regeneration within and beyond current red spruce stands in anticipation of future ecological shifts.
Service Quality in Rail Systems: Listen to the Voice of Social Media

Service quality is essential to increase and maintain user loyalty to the railway system. In the literature, surveys have been used to measure user satisfaction, and mathematical methods have been applied to quantify the survey results. In recent years, user-generated content, including comments and complaints shared via social media, has been used to measure the quality of rail services. This content may provide important insights into the quality of the service provided with its dynamic structure. In this study, a SERVQUAL-based social-media analytics approach is used to measure railway service quality, placing special emphasis on the temporal variations in a national rail system. Topic modeling was used to assign each content item to the relevant service dimension and sentiment analysis was applied to measure the level of satisfaction. Importance–performance analysis was employed at the final stage to generate policy suggestions. Gathering more than 2.3 million social-media messages posted from 2011 to 2021, we examined the temporal evolution of service quality of the Turkish rail system. The results reveal the most and least important services and the satisfaction level of each dimension. The differences between the priorities of conventional and high-speed rail passengers are defined, and policy recommendations are presented.
EXOS D (Akebono) suprathermal mass spectrometer observations of the polar wind

We report observations of the H+, He+, and O+ polar wind ions in the polar cap (>80° invariant latitude, ILAT) above the collision-dominated altitudes (>2000 km), from the suprathermal mass spectrometer (SMS) on EXOS D (Akebono). SMS regularly observes low-energy (a few eV) upward ion flows in the high-altitude polar cap, poleward of the auroral oval. The flows are typically characteristic of the polar wind, in that they are field-aligned and cold (Ti 80° ILAT), the average H+ velocity reached 1 km/s near 2000 km, as did the He+ velocity near 3000 km and the O+ velocity near 6000 km. At Akebono apogee (10,000 km), the averaged H+, He+, and O+ velocities were near 12,7, and 4 km/s, respectively. Both the ion velocity and temperature distributions exhibited a day-to-night asymmetry, with higher average values on the dayside than on the nightside.
Evaluation of dielectric-based probes for expansive soils: application to Regina clay.

Much experience has been gained with the use of the dielectric methods in granular or fine-grained soil with low to medium plasticity. Empirical equations were proposed to describe the relationship between water content and measured bulk dielectric constant of the soils. However, the proposed empirical equations are generally not considered applicable for highly plastic, expansive soils due to factors such as bound water and high electric conductivity. This paper presents calibration equations for various commercially available dielectric-based probes. The calibration curves have been determined through laboratory calibration using compacted specimens. The differences between the calibration curves and those predicted by the empirical equations, as well as those provided by the manufacturer, are assessed and discussed. The effect of temperature on the response of the probes was also studied.
Following Natural Autoantibodies: Further Immunoserological Evidence Regarding Their Silent Plasticity and Engagement in Immune Activation

Contradictory reports are available on vaccine-associated hyperstimulation of the immune system, provoking the formation of pathological autoantibodies. Despite being interconnected within the same network, the role of the quieter, yet important non-pathological and natural autoantibodies (nAAbs) is less defined. We hypothesize that upon a prompt immunological trigger, physiological nAAbs also exhibit a moderate plasticity. We investigated their inducibility through aged and recent antigenic triggers. Anti-viral antibodies (anti-MMR n = 1739 and anti-SARS-CoV-2 IgG n = 330) and nAAbs (anti-citrate synthase IgG, IgM n = 1739) were measured by in-house and commercial ELISAs using Croatian (Osijek) anonymous samples with documented vaccination backgrounds. The results were subsequently compared for statistical evaluation. Interestingly, the IgM isotype nAAb showed a statistically significant connection with anti-MMR IgG seropositivity (p < 0.001 in all cases), while IgG isotype nAAb levels were elevated in association with anti-SARS CoV-2 specific seropositivity (p = 0.019) and in heterogeneous vaccine regimen recipients (unvaccinated controls vector/mRNA vaccines p = 0.002). Increasing evidence supports the interplay between immune activation and the dynamic expansion of nAAbs. Consequently, further questions may emerge regarding the ability of nAAbs silently shaping the effectiveness of immunization. We suggest re-evaluating the impact of nAAbs on the complex functioning of the immunological network.
Holocene development of a peatland (southern Québec): a spatio-temporal reconstruction based on pachymetry, sedimentology, microfossils and macrofossils

This study examines the relationships between allogenic and autogenic processes during the Holocene development of a southern Quebec bog. Local vegetation, surface moisture and peat accumulation were independently reconstructed from palaeoecological data (microfossils, macrofossils, loss-on-ignition and radiocarbon dating) and sedimentological analyses conducted on seven profiles. The observed successional stages, from pond to marsh, rich fen, poor fen then bog, represents a typical hydrosere. The early wetland development provides an obvious illustration of the facilitation model: each community modified the hydrological conditions by means of peat accumulation which then favoured the onset of the succeeding stage. No direct link is evidenced between vegetation, moisture and peat accumulation, while all of them clearly reveal the initial influence of minerotrophic groundwater supply. Notably, the decrease in this allogenic influence is reflected by the increasing asynchrony of local vegetation change. The comparison of the seven profiles also shows several asynchronous moisture fluctuations at the peatland scale but none seems to be related to climate. In contrast, net peat accumulation shows similar trends in all marginal profiles and at the peatland scale. As a consequence of the initial minerotrophic supply, peat-accumulation rates were high during the early Holocene and low during the midand late Holocene. Our results, which show the major influence of groundwater and autogenic processes on peat accumulation, strongly contrast with the general climatic control recognized for European peatlands.
Notes on Hydraena (Phothydraena) atrata Desbrochers des Loges, 1891, with comments on the Iberian species of the subgenus (Coleoptera: Hydraenidae)

The distribution of Hydraena (Phothydraena) atraia Desbrochers des Loges, 1891 is extended to several localities in North-east and Central Spain, being recorded for the first time in Portugal. In coexisting populations, the species can be externally separatedfromif. (P.) testacea Curtis, 1830by its broader and less chitinized elytral epipleura. It was found mainly in habitais with stagnant or slowly flowing turbid water, steep edges, and silt substratum. It also occurred in temporary fens, the edges of streams, and in artificial habitats, sometimes in high densities. Phenology and relative abundance through the year indicates a univoltine life cycie, with overwintering adults and late spring or early sunimer breeding. The same life cycle was observed in H. testacea, with which it coexisted in most of the sites. Peakpopulation densities were found in early autumn. The third Iberian species of the subgenus, H. (P.) he mando i Fresneda & Lagar, 1990 is recorded for the first time after its description from several localities south of the Guadalquivir river.