Miracle-dz/UniFAR-FTUs huggingface dataset:
The Staphylococcus aureus Network Adaptive Platform Trial Protocol: New Tools for an Old Foe

Abstract Staphylococcus aureus bloodstream (SAB) infection is a common and severe infectious disease, with a 90-day mortality of 15%–30%. Despite this, <3000 people have been randomized into clinical trials of treatments for SAB infection. The limited evidence base partly results from clinical trials for SAB infections being difficult to complete at scale using traditional clinical trial methods. Here we provide the rationale and framework for an adaptive platform trial applied to SAB infections. We detail the design features of the Staphylococcus aureus Network Adaptive Platform (SNAP) trial that will enable multiple questions to be answered as efficiently as possible. The SNAP trial commenced enrolling patients across multiple countries in 2022 with an estimated target sample size of 7000 participants. This approach may serve as an exemplar to increase efficiency of clinical trials for other infectious disease syndromes.
Association between socioeconomic factors and origin of hospital referrals among patients with oral cancer

Background The Brazilian Unified Health System (SUS) is responsible for offering free assistance to more than 100 million Brazilians, including treatment of oral cancer lesions. Considering that the Brazilian public system aids the most vulnerable population, this study analyzed whether the origin of hospital referrals of patients with oral cancer is associated with socioeconomic factors. Material and Methods A cross-sectional study was carried out from cancer hospital records of the National Cancer Institute (RHC-INCA), considering the primary locations (C00 to C06) diagnosed between 2016 and 2019. Data on gender, skin color (white and non-white), education (no schooling, incomplete or complete elementary education; high school; incomplete and complete higher education) and origin of referral (SUS and non-SUS) were analyzed by multiple logistic regression (p<0.05). Results Higher referral rates by the SUS were observed in 2017 (OR=1.27; 95% CI=1.098-1.480) and 2018 (OR=1.28; 95% CI=1.101-1.490); no differences were found between the years 2016 and 2019. Regarding gender, men were 40% more likely to have the SUS as the source of referral (OR=1.40; 95% CI=1.233-1.600). Non-white individuals were 34% more likely to have the SUS as the source of the referral (OR=1.34; 95% CI=1.190-1.512). Illiterate individuals or individuals who only attended elementary school were 6.38 times more likely to be referred by the SUS than individuals with higher education (OR=6.38; 95% CI=5.228-7.796). Conclusions It is concluded that the origin of hospital referrals via SUS of patients with oral cancer is associated with socioeconomic factors. Key words:Mouth neoplasms, oral diagnosis, health service coverage.
PENGARUH STRES KERJA DAN BEBAN KERJA TERHADAP KINERJA KARYAWAN PDAM SURABAYA

One of the factors which have influence to the success level of the organization is employees’ performance. One of the efforts to improve the employees’ performance is by pying attention to the job stress and workload. The purpose of this research is to find out the influence of job stress and workload either simultaneously and partially to the employees’ performance of PDAM Surabaya. The research sample are 89 employees’. The multiple linear regressions, F test, and t test are used as the analysis techniques. The result of the research shows that simultaneously and partially job stress and workload have significant influence to the employees’ performance. It has been proven by using F-test which shows that the significant value is 0,000 lest than 0,05. The t-test result shows that partially job stress and workload have significant influence to the employees’ performance. It has been proven by using ttest which shows that the significant valueof all independent variables are less than 0,05 which is 0,047 for the job stress and 0,005 for the workload. The result of the t-test has found that variable which have dominant influense to the employees’ performance is workloadsince its significant value is less than the job stress. Keywords: job stress, workload, employees’ performance
Logarithmic topological Hochschild homology of topological K-theory spectra

In this paper we continue our study of logarithmic topological Hochschild homology. We show that the inclusion of the connective Adams summand into the p-local complex connective K-theory spectrum, equipped with suitable log structures, is a formally log THH-etale map, and compute the V(1)-homotopy of their logarithmic topological Hochschild homology spectra. As an application, we recover Ausoni's computation of the V(1)-homotopy of the ordinary THH of ku.
Suppressing Intrinsic Spin Harmonics at the AGS

Over the last decade several improvements have been made to increase the polarization of the proton beam at the Brookhaven Alternating Gradient Synchrotron (AGS) [1]. A partial snake was installed to overcome all imperfection resonances in the energy range of the AGS [2]. The rf dipole concept to preserve polarization at strong intrinsic resonances has been demonstrated at the AGS for the first time [3]. Polarization losses have been observed at weak intrinsic resonances. One method to preserve polarization at weak intrinsic resonances is to change the betatron tune rapidly before crossing the resonance. Due to the non-adiabatic nature of this tune jump, the beam emittance will increase [4]. More efficient is a method called suppressing intrinsic spin harmonics, first successfully applied at the Cooler Synchrotron COSY [5]. In this presentation we describe how to use this method at the AGS [6].
Variations in the D/H Ratio of Extended Sight Lines from Far Ultraviolet Spectroscopic Explorer Observations

We use new FUSE data to determine the column densities of interstellar D I, N I, O I, Fe II, and H2 along the HD 41161 and HD 53975 sight lines. Together with N(H I) from the literature, we derive D/H, N/H, and O/H ratios. These sight lines have log N(H ) > 21.00 and probe gas up to ~1300 pc, allowing us to determine the gas-phase D/H ratio in a hydrogen column density range, log N(H) > 20.70, where the only five measurements available in the literature yield a weighted average of D/H = (0.86 ± 0.08) × 10-5. We find D/H = (2.14) × 10-5 along the HD 41161 sight line. This ratio is ~3 σ higher than the weighted mean D/H ratio quoted above, while the D/H ratio for the HD 53975 line of sight, D/H = (1.02) × 10-5, agrees within the 1 σ uncertainties. Our D/H measurement along the HD 41161 sight line presents the first evidence of variations of D/H at high N(H). Our result seems to indicate either that the long sight lines that, according to the deuterium depletion model, are dominated by cold undisturbed gas where deuterium would be depleted onto carbonaceous grains occur at higher N(H) than previously thought, or that the clumping of low D/H values in the literature for the long sight lines has another explanation. Both of the O/H ratios derived here, (9.12) × 10-4 and (5.37) × 10-4 (for HD 41161 and HD 53975, respectively), are higher than what has been found by other authors. Finally, we derive (N/H) × 105 = 8.32 and 5.07, and (D/O) × 102 = 2.29 and 1.91, for HD 41161 and HD 53975, respectively. In addition, the relatively high signal-to-noise ratio of the HD 41161 data allows us to place constraints on the f-values of some neutral chlorine transitions present in the FUSE bandpass for which only theoretical values are available.
The acoustic change complex for measuring speech perceptual performance in normal hearing listeners in noise, cochlear implant users, and second language listeners

A series of experiments recorded the acoustic change complex (ACC) to a broad range of speech stimuli. The ACC is an electrophysiological response to an acoustic change within an on-going stimulus. Recordings were obtained from normal hearing (NH) listeners in noise, cochlear implanted (CI) listeners, and second language listeners. Chapter 2 presented a mixture of transitions between four vowels and four fricatives in quiet and at three noise levels to NH listeners. We investigated how the ACC was affected by noise, and how the ACC relates to individuals’ behavioural speech-in-noise ability. Chapter 3 details a CI study using the same fricative and vowel stimuli but in quiet only. The ACC was measured and again compared to behavioural speech perception performance. Participants’ neural entrainment to continuous speech was also measured, and compared to their speech perception performance and ACC responses. Chapter 4 details an ACC study using a mixture of transitions between eight voiceless fricatives presented to native English, Finnish and Polish speakers. The ACC magnitude was used to create similarity matrices that were analysed by non-metric MDS and an acoustic analysis of the fricative stimuli was performed. The ACC and its relationship to the spectra of the stimuli were used to investigate cross language differences between the groups. Overall, results suggest that the ACC is not merely a measure of general auditory detection as it is often described, but rather it is a measure at the border between auditory and linguistic processing in the auditory cortex. Furthermore, the results indicate that the ACC has potential for further use in research in a variety of listener populations, as well as potential clinical benefits.
The classification of Kleinian surface groups I : Models and bounds : preprint

We give the first part of a proof of Thurston’s Ending Lamination conjecture. In this part we show how to construct from the end invariants of a Kleinian surface group a “Lipschitz model” for the thick part of the corresponding hyperbolic manifold. This enables us to describe the topological structure of the thick part, and to give a priori geometric bounds.
Care and Handling of Univariate Outliers in the General Linear Model to Detect Spuriosity- A

We deal with the situation covered by the univariate general linear model, that is, it is intended that n observations be generated in accordance with the usual model y = Xβ + e however, it is feared that k of the observations are spurious, that is, not generated in the manner intended, so that for an unknown set of k distinct integers, say (i 1, … ik ), a subset of the first n integers, we have, specifically, that ytj , = x tj ′, β + a j , + ∊ tj , where in general x t ′ denotes the t-th row of X, and where (a 1, …, a k ), so called shift parameters, are such that – ∞ < a j , < ∞. In this paper, we discuss the posterior distribution of β, when indeed it is assumed a priori that any given set of k observations has uniform probability I/( n k ) of being spurious. The properties of the posterior of β are discussed, and the results used in an example using data generated from a response surface design. Ad hoc procedures are discussed for gaining information on k, when k is unknown. These ad hoc procedures ar.
from in the Gut

Clan CD cysteine peptidases, a structurally related group of peptidases that include mammalian caspases, exhibit a wide rangeofimportantfunctions,alongwithavarietyofspecificities and activation mechanisms. However, for the clostripain family (denoted C11), little is currently known. Here, we describe the first crystal structure of a C11 protein from the human gut bac-terium, Parabacteroides merdae (PmC11), determined to 1.7-Å resolution. PmC11 is a monomeric cysteine peptidase that com-prises an extended caspase-like (cid:2) / (cid:3) / (cid:2) sandwich and an unusual C-terminal domain. It shares core structural elements with clan CD cysteine peptidases but otherwise structurally differs from the other families in the clan. These studies also revealed a well ordered break in the polypeptide chain at Lys 147 , resulting in a largeconformationalrearrangementclosetotheactivesite.Bio-chemical and kinetic analysis revealed Lys 147 to be an intramolecular processing site at which cleavage is required for full activation of the enzyme, suggesting an autoinhibitory mechanism for self-preservation. PmC11 has an acidic binding pocket and a preference for basic substrates, and accepts substrates with Arg and Lys in P1 and does not require Ca 2 (cid:4) for activity. Collec-tively, these data provide insights into the mechanism and activity of PmC11 and a detailed framework for studies on C11 peptidases from other phylogenetic kingdoms.
Problems of steel construction modal models identification Problemy identyfikacji modeli modalnych stalowych ustrojów nośnych

Complex identification of steel construction modal models requires simultaneous numerical and experimental analysis of the object. Such an approach allows to obtain more accurate results while the methods complement each other. Results presented, concern stacker feeding bridge which operates in open pit mine. Operational modal analysis was made. Application of this method enables to assess influence of working condition on the modal characteristic. Experimental results were validated with use of numerical method.
The Fire Safety of Granular Propellant Handling Facilities

This thesis examines an industry-related problem in the field of solid granular propellant combustion. Through a literature review, it has been found that the safety aspects of propellants installations have not been well defined and studied. Such lack of standard could potentially lead to industrial accidents of varying magnitudes. The present project studies the flame propagation, heat output and pressure generated by the combustion of a range of propellants configurations. An experimental approach is first used to obtain a reliable set of data. Models are then obtained through the comparison of the empirical data with theoretical considerations, scaling and numerical simulations. Using the generated models, it shall eventually be possible to apply the findings in conceiving a set of guidelines for the safe design of propellant installations. Flame propagation is central to the study of propellant combustion. Through the examination of video recordings from an array of propellant fire tests, it is possible to observe three main flame propagation modes: radiation heat transfer (ideal case), contact with burning projections and engulfment by a fireball. The maximum event dimensions depend on the dominant mode. A decision tree scheme is used to breakdown the possible events in the various propagation modes and assign conditions for their occurrence. Application of the methodology on a small scale flame propagation test shows that it is possible to scale the results to larger scale cases and obtain propagation rate estimates. In both the radiant heat flux and pressure generation cases, theoretical forms are derived based on previous work and theoretical principles. Statistical analyses of the experimental results show good agreement with general theoretical forms. It is shown that one must, however, be attentive to possible collinearities and variable factors when interpreting statistical results. By taking into account the theoretical expectations, it is possible to estimate these additional factors and obtain models that are more generally applicable. It is also shown that the general models rely heavily on the combustion rate of the propellant configuration. This shows that the flame propagation analysis is an important part of estimating the various fire safety parameters of granular propellants.
Status of Noise Pollution in an Around Jharsuguda Urban Area

In the present investigation, it was found that the sound of industrial zone in day time it is more [77.46 dB (A)] where as in commercial zone sound is less [60.0 dB (A)] with respect to ambient noise quality standard. The sound label of residential zone is [63.84 dB (A)], which is more than the ambient noise standard value but in the silence zone the sound is less [44.43 dB (A)] then the standard data. The average sound level in dB (A) of industrial commercial, residential zone even at night the sound is more in the zone. However at night silence zone is more silence [33.2 dB (A)] than the ambient noise standard.
CEO as “Chief Crisis Officer” under COVID-19: A Content Analysis of CEO Open Letters Using Structural Topic Modeling

ABSTRACT This study seeks to explore how business leaders should respond to COVID-19. In advancing theoretical development of strategic crisis communication, we incorporated theoretical frameworks of organizational resilience, social support, and values-centered communication to make sense of CEO’s COVID-19 responses. Using structural topic modeling, this study analyzed 192 CEO open letters from 152 multinational corporations that are listed on the 2020 Fortune Magazine’s World’s Most Admired Companies. Fourteen valid topics and four general themes were identified and discussed. Results suggested that in those letters, CEOs demonstrated organizational resilience by giving sense to current crisis situations and expressing their self-efficacy and response efficacy in handling challenges, which supported the conceptualization and operationalization of organizational resilience in this new crisis context. Additionally, both emotional and instrumental support provisions were found in CEOs’ letters. A values-centered and care ethics communication approach was widely taken in CEOs’ messages, highlighting the importance of social solidarity in facing a public health crisis. This study also explored how topic prevalence varied by business sectors and CEOs’ genders and associated with companies’ financial performance. These summarized communication strategies and narrative topics shed light on crisis communication practice and theory, especially in the context of a global public health crisis.
How Purpose-Driven Organizations Influenced Corporate Actions and Employee Trust during the Global COVID-19 Pandemic

ABSTRACT The COVID-19 global pandemic drove many companies to reevaluate their approach to business and, as a result, some focused their efforts on leading with purpose. Purpose is an organization's fundamental goal that goes beyond profit maximization. It is an all-encompassing principle that guides everything the organization does and determines its strategies. Effective strategic communication is an essential element of purpose as it can empower employees to align their personal goals with organizational values and thus more closely identify with their organization. However, while the benefits of purpose are frequently proclaimed in practical literature, the impact of communicating purpose on employee outcomes remains unexplored in strategic communication research. To address this critical research gap, this study examined why and how communicating purpose could be an effective tactic in strategic communication. Specifically, this study introduced the concept of purpose and examined how purpose directed organizations’ actions in response to COVID-19 as well as the impact of purpose on employees’ organizational identification and trust. The findings offer practical implications regarding the importance of strategic communication about purpose in terms of building employee organizational identification and trust during times of change.
Axo-vascular coupling mediated by oligodendrocytes

The high energy requirements of the cortical gray matter are met by the precise cooperation of neurons, glia, and vascular cells in a process known as neurovascular coupling (NVC). In contrast, the existence and significance of NVC in white matter (WM) are still debated and basic regulatory mechanisms are unknown. We recently discovered that oligodendrocytes sense the spiking axons’ activity via NMDA receptors and regulate their cell surface expression of glucose transporter GLUT1 allowing an increase in glycolytic metabolism that enables lactate release to metabolically support the axons. Here, we show for the mouse optic nerve (ON), a model WM tract, that the vascular support is also dynamically controlled. Axonal spiking activity induces small vessel dilations which are sustained for more than 20 minutes upon the ending of electrical stimulation. Pharmacological inhibition shows that the electrically evoked dilation is mediated by the prostaglandin E2 receptor EP4 and can be modulated by the oxygen concentration, as has been shown in the grey matter. Importantly, we found in ONs from conditional mouse mutants that oligodendroglial NMDA receptors are required for this type of neurovascular response, demonstrating a critical role of oligodendrocytes in coupling axonal activity to pericyte function. Reminiscent of NVC in cortical slices, the “axo-vascular” response is slower and may represent a more rudimentary form of neurovascular coupling.
Modeled grid cells aligned by a flexible attractor

Entorhinal grid cells implement a spatial code with hexagonal periodicity, signaling the position of the animal within an environment. Grid maps of cells belonging to the same module share spacing and orientation, only differing in relative two-dimensional spatial phase, which could result from being interconnected by a two-dimensional attractor guided by path integration. However, this architecture has the drawbacks of being complex to construct and rigid, path integration allowing for no deviations from the hexagonal pattern such as the ones observed under a variety of experimental manipulations. Here we show that a simpler one-dimensional attractor is enough to align grid cells equally well. Using topological data analysis, we show that the resulting population activity is a sample of a torus, while the ensemble of maps preserves features of the network architecture. The flexibility of this low dimensional attractor allows it to negotiate the geometry of the representation manifold with the feedforward inputs, rather than imposing it. More generally, our results represent a proof of principle against the intuition that the architecture and the representation manifold of an attractor are topological objects of the same dimensionality, with implications to the study of attractor networks across the brain.
Gray matter cortical thickness predicts individual pain sensitivity: a multi-center machine learning approach

Pain sensitivity is known to considerably vary across individuals. While the variability in pain has been linked to structural neural correlates, it is still unclear how well these findings replicate in independent data and whether they are powerful enough to provide reliable pain sensitivity predictions on the individual level. In this study, we constructed a predictive model of pain sensitivity utilising structural MRI-based cortical thickness data from a multi-center dataset (3 centers, 131 healthy participants). Cross-validated estimates revealed a statistically significant and clinically relevant predictive performance (Pearson’s r = 0.36, p < 0.0005). The predictions were found to be specific to pain sensitivity and not biased towards potential confounding effects (e.g., anxiety, stress, depression, center-effects). Analysis of model coefficients suggests that the most robust cortical thickness predictors of pain sensitivity are the right rostral anterior cingulate gyrus, left parahippocampal gyrus and left temporal pole. Cortical thickness in these regions was negatively correlated to pain sensitivity. Our results can be considered as a proof-of-concept for the capacity of brain morphology to predict pain sensitivity, paving the way towards future multimodal brain-based biomarkers of pain. Highlights We present a robust, brain structure-based multi-center predictive model for pain sensitivity. Our model based on gray matter cortical thickness explains 13% of the variance in pain sensitivity and generalizes to out-of-center data. The predictions are specific to pain sensitivity and not driven by potential confounders such as stress, depression, anxiety, and center-effects. The most important predictors were rostral anterior cingulate cortex, parahippocampal gyrus and temporal pole, all negatively correlated with pain sensitivity.