Miracle-dz/UniFAR-FTUs huggingface dataset:
Misconceptions of mathematics in higher education universities when learning with Google classroom based on learning styles and gender differences

The purpose of this study is to comprehensively describe the results of the analysis of the ability to understand concepts and misconceptions in terms of differences in learning styles, as well as gender differences. The data to be collected in this study is in the form of primary data and secondary data. The primary data is obtained from primary sources and secondary data is obtained from secondary sources. The primary source in this study is informants, namely students, and the secondary source is documentation of student test scores as an illustration of student abilities. The instruments in this study are student learning style tests and auxiliary instruments in the form of misconception diagnostic tests. Learning style test in the form of a questionnaire. This instrument is used to uncover visual, auditorial, and kinesthetic learning style variables. Misconception diagnostic tests use the Certainty of Response Index (CRI). The results of the CRI analysis based on student answer criteria are: (a) 5.83% of student problem solving do not know the concept (lucky guess); (c) 22.30% of the student problem solvers did not know the concept; (b) 50.18% of student problem solving mastered the concept well; and (d) 21.69% of student problem solving occurred misconceptions.
Tislelizumab in combination with gemcitabine plus cisplatin chemotherapy as rst-line adjuvant treatment for locally advanced or metastatic bladder cancer: a retrospective study

Xiang Ren Huazhong University of Science and Technology Yiqun Tian Huazhong University of Science and Technology Zhixian Wang Huazhong University of Science and Technology Jing Wang Huazhong University of Science and Technology Xing Li Huazhong University of Science and Technology Yisheng Yin Huazhong University of Science and Technology Ruibao Chen Huazhong University of Science and Technology Ying Zhan Huazhong University of Science and Technology Xiaoyong Zeng (  miwai@163.com ) Huazhong University of Science and Technology
The Effects of Online Flipped Reading Instruction Utilizing Scaffolding and Digital Badges on EFL Deep Comprehension and Reading Engagement

Due to the COVID-19 situation, fully online flipped learning that combines online asynchronous learning activities followed by online synchronous discussions and tasks emerged as a working instructional model that provides a conducive learning environment. This study examined the extent to which online flipped reading instruction utilizing scaffolding and digital badges improved deep reading skills and reading engagement of EFL university students at Port Said Faculty of Education. Students were provided with online flipped reading instruction delivered via Edmodo and Google Classroom for reading expository texts. Sixty-eight English-majored freshmen at Port Said Faculty of Education participated in this study. A mixed-methods research design was employed with multiple sources of data, including the pre-and post-tests of deep reading comprehension, the reading engagement questionnaire
Exploring Project Success Factors in Developing Countries: Focus on Morocco

Although project management (PM) literature has addressed project success, attention has not been paid to statistically testing the relationship between various critical success factors (CSFs) and project success in developing countries. Determining the most relevant factors can optimize efforts and boost the project success dimension in this specific environment that struggles to achieve the desired development objectives. Therefore, the aim of this paper is to statistically prove the relationship between project success and an extant range of selected CSFs that englobe PM variables, organization structure, project manager competencies, communication, top management, risk management, and prioritize them to provide valuable information to project managers and enhance the likelihood of project success. The data were collected by means of a survey addressed to project managers and practitioners from Morocco in both public and private sector. Multiple stepwise regressions were conducted to uncover the relationship between each success criteria and the considered CSFs. The results show that the considered model for the first factor of project success covers 59,1% of its variance. The significant variables of this model are PM competencies and PM KPI that increase the success of the first factor by 49% and 29%, respectively. The variance of the second factor of project success is explained by 68%. The significant independent variables are communication, top management support, PM Partnership, PM KPI, and PM policy and strategy. According to the results, the variables participate in project success by 37%, 28,1%, 19,8% 29,9% and 15,5%, respectively.
Effects of American drama familiarity on Chinese people’s remote acculturation, attitudes, and watching intentions

The study aims to examine the impacts of American drama familiarity on Chinese people’s remote acculturation to American culture, attitudes towards American dramas, and watching intentions of American dramas. A total of 358 survey data points from Chinese respondents were collected, and structural equation modeling (SEM) analysis was conducted in an effort to verify the research hypotheses. The research outcomes indicate that American drama familiarity significantly positively impacts American cultural orientation, attitudes towards American dramas, and watching intentions of American dramas, but does not significantly bear upon Chinese cultural orientation. American cultural orientation significantly positively affects attitudes towards American dramas. Additionally, Chinese cultural orientation significantly negatively influences attitudes towards American dramas. Attitudes towards American dramas engender significant positive effects on watching intentions for American dramas. American drama familiarity, the remote acculturation of Chinese people to American culture, attitudes towards American dramas, and watching intentions of American dramas are significantly interrelated. The research is only targeted at Chinese people, and the remote acculturation is bi-dimensional in this study. Thereby, the remote acculturation of local people to multiple cultures simultaneously ought to be delved into in subsequent research. It is recommended that stakeholders and marketers of American dramas take essential marketing measures to increase the familiarity of Chinese people with American dramas and promote their friendly attitudes toward American dramas. This study contributes to yielding empirical evidence for the interrelation between American dramas and the remote acculturation of Chinese people to American culture.
Assessment of Heavy Metal Contamination of Soils and Plants in and around Open Cast Mines of Sukinda, India

Mining activities generate huge amount of wastes with extremely high concentrations of heavy metal that have adverse effects on ecosystems and human health. Metal contamination extended several kilometers away from the mine sites probably by wind and water. Native vegetation was directly affected by the pollution. Hence, understanding the dynamic of metals in soil and plants is essential for ecosystem management and risk assessment. The present study was designed to assess the toxic metals viz. , lead (Pb), cadmium (Cd), nickel (Ni) and chromium (Cr) present in the soil and plant samples of 18 plant species collected from nearby areas Sukinda chromite mining zone. Samples of soil and plants were collected from six different sites and were analyzed for pH, EC, Cr, Cd, Pb and Ni by pH meter, conductivity meter and atomic absorption spectrophotometer, respectively. Soil pH was slightly acidic in nature and varied from 5.5 to 6.4. Total heavy metal concentrations in soils were in the order of Cr> Ni> Pb> Cd. Cr and Ni exceed the critical limit value of WHO specified standard. Accumulation of metals in the plant species and in their organs varies, e.g. accumulation of heavy metal was higher in stem as compared to leaf. Ailanthus excelea Roxb. has highest capability for accumulating Cr in the shoot part as compared to other collected plants. The plants can ideally be used as the possible application in agricultural reconnaissance surveys, reclamation and revegetation of adversely affected mining environment.
Risk of severe immune-related adverse events in cancer patients with pre-existing autoimmunity receiving immune checkpoint inhibitor therapy

Introduction: Immune checkpoint inhibitors (ICI) are widely used cancer therapies that harness the immune system to target malignant cells but subsequently can cause serious off-target immune-related Adverse Effects (irAEs). Patients with pre-existing autoimmune disease have historically been excluded from ICI clinical trials due to scientific concerns over increased risk of irAEs and flares of underlying autoimmune disease.Methods: We designed a retrospective, single-center, case-control study at a large, academic medical center to evaluate the incidence and severity of irAEs in patients with pre-existing autoimmunity compared to controls. Controls were matched 2:1 for age, sex, cancer histology, and ICI class. Patients were identified with ICD 9 and 10 codes followed by manual chart extraction. Cases were defined as patients with pre-existing, systemic autoimmunity. The primary outcome was severe irAE (Grade 3 or higher by Common Terminology Criteria for Adverse Events) within 6 months of ICI therapy. Secondary outcomes included response to ICIs, resolution of the irAE, ICI rechallenge success, and survival. Statistical analyses were performed by Chi-square, Fishers exact, Mann-Whitney, and Log-rank tests.Results: Of 3,130 patients treated with ICIs from 2015-2021, 28 cases with pre-existing autoimmune disease were identified and were matched with 56 controls. Pre-existing autoimmune conditions included antiphospholipid syndrome, inflammatory polyarthritis, juvenile rheumatoid arthritis, multiple sclerosis, psoriatic arthritis, rheumatoid arthritis, and type I diabetes. Multiple cancer histologies, including genitourinary, gynecologic, head & neck, hepatobiliary, lung, melanoma, and pancreatic, were represented. Six of 28 cases (21.4%) experienced severe irAEs compared to 9/56 (16.1%) controls; the odds of developing a severe irAE were not significantly different (OR 0.43, 95% CI 0.083-2.33, p = 0.627, ns). Moreover, there were no significant differences in overall survival or tumor response between the two groups. The majority of irAEs resolved without long-term sequelae (66.7% of cases, 55.6% of controls). The majority of patients who were rechallenged with ICIs were successful in continuing therapy (66.7% of cases, 100% of controls). Conclusion: Our study suggests that patients with pre-existing autoimmune disease can be treated with ICI cancer therapies and experience rates of severe irAEs and overall survival that are similar to those of the general population. These data can aid oncologists in discussing risks and benefits of ICIs when treating patients with pre-existing autoimmunity and solid tumors.
Disclosing the effects of climate, land use, and water demand as drivers of hydrological trends in a Mediterranean river basin

Mediterranean basins face significant water scarcity which demands examining long-term data to prospect their trends in water availability and quality. This study focuses on The Onyar River (Inner Catalan basins, NE Spain), to explore its historical streamflow changes, the influencing climatic and land-use factors, and the consequential impacts on water quality. We analyse key hydro-climatic variables—streamflow, precipitation, temperature, and evapotranspiration (both PET and AET)— across a 60-year span (1960 -2020) and their relationship with recent stream water chemistry data (2007-2020). We compare these patterns to the changes in land use, and to the variations in water demand according to urban use, livestock, and crop production estimates. Our findings highlight a consistent decline in streamflow, most pronounced over the last two decades, accompanied by an increase in PET, and a probable decrease in groundwater recharge. Notably, these changes co-occurred with higher concentrations of river water ammonium and nitrate. We attribute these patterns to changes in land use such as afforestation and intensive fertilization, as well as increased groundwater withdrawal, particularly during irrigation seasons. Additional factors include growing urban water demand and the discharges of treated wastewater back into the river system. This study offers a comprehensive overview of the declining water quantity and quality in the Onyar River, attributing these trends to an interplay of climatic and anthropogenic factors. The findings underscore the need for integrated water resource management strategies to mitigate the implications of these changes.
Different fates of metabolites and small variation in chemical composition characterise frass chemistry in a specialist caterpillar

Specialist and generalist insect herbivores evolved different strategies to process host‐plant metabolites. We explored frass composition in Laothoe populi (L.) caterpillars (Lepidoptera: Sphingidae), a specialist moth species that is closely associated with plants of the Salicaceae (Mirb.) family. We fed the caterpillars with leaves from three willow species (Salix caprea L., S. purpurea L. and S. viminalis L.), one willow hybrid (S. x rubens Schrank) and one poplar species (Populus tremula L.). Using untargeted metabolomics, we compared the chemical composition and variation among leaf and frass samples. We quantified the chemical variation using either a simple index based on the presence and concentration of metabolites (i.e., Bray‐Curtis) or an index that additionally accounts for chemical structural‐compositional similarity (CSCS) among metabolites. Due to the high degree of dietary specialisation, we expected low host‐specific variation in frass composition among the caterpillars. Based on literature, we further hypothesised that ingested salicinoids will be largely modified in the caterpillar gut while flavonoids will be often passively excreted. Finally, we compared chemical variation among the samples when quantified with Bray‐Curtis or CSCS metrics. As expected, we found relatively low host‐specific variation in the chemical composition of caterpillar frass. Our results further suggest that flavonoids were largely passively excreted by the caterpillars, while salicinoids were metabolised in the gut. Finally, we found that chemical composition measures based on Bray‐Curtis overestimated the differences in chemical composition between frass and leaves, suggesting that for these type of samples CSCS measures are better suited to reflect metabolic changes more realistically.
Germline DNA damage response gene mutations as predictive biomarkers of immune checkpoint inhibitor efficacy

Background Impaired DNA damage response (DDR) can affect immune checkpoint inhibitors (ICI) efficacy and lead to heightened immune activation. We assessed the impact of pathogenic or likely pathogenic (P/LP) germline DDR mutations on ICI response and toxicity. Materials and methods A retrospective analysis of 131 cancer patients with germline DNA testing and ICI treatment was performed. Results Ninety-two patients were DDR-negative (DDR-), and 39 had ≥1 DDR mutation (DDR+). DDR+ patients showed higher objective response rates (ORRs) compared to DDR- in univariate and multivariable analyses, adjusting for age and metastatic disease (62% vs. 23%, unadjusted OR = 5.41; 95% CI, 2.41-12.14; adjusted OR 5.94; 95% CI, 2.35-15.06). Similar results were seen in mismatch repair (MMR), DDR pathways with intact MMR (DDR+MMRi), and homologous recombination (HR) subgroups versus DDR- (adjusted OR MMR = 24.52; 95% CI 2.72-221.38, DDR+MMRi = 4.26; 95% CI, 1.57-11.59, HR = 4.74; 95% CI, 1.49-15.11). DDR+ patients also had higher ORRs with concurrent chemotherapy (82% vs. 39% DDR-, p=0.03) or concurrent tyrosine kinase inhibitors (50% vs. 5% DDR-, p=0.03). No significant differences in immune-related adverse events were observed between DDR+ and DDR- cohorts. Conclusion P/LP germline DDR mutations may enhance ICI response without significant additional toxicity.
Implicit cooperation? The northeast atlantic mackerel fishery

This paper presents a quarterly, game-theoretic model of the Northeast Atlantic mackerel to study the fishing strategies of five players, the EU, Norway, the Faeroe Islands, Iceland, and the international fishery on the high seas. Data on the spatial distribution of fish catches 19772011 are used to model changes in the distribution of the mackerel stock. The Nash equilibrium solutions predict a severe decimation of the stock through overfishing, either by parties (Iceland, the Faeroe Islands) that refuse to cooperate, or by a general absence of cooperation. There is a wide discrepancy between this prediction and reality, as the stock seems only moderately overexploited or not at all, despite non-cooperation by Iceland and the Faeroe Islands. It is conjectured that these parties, and others, may have a degree of implicit cooperation that falls somewhat short of full cooperation but avoids the extreme destruction of the Nash equilibrium. This implicit cooperation can be seen as being maintained by a mutually assured destruction of the fisheries of all parties in case they go to the logical extremes of non-cooperation.
Comparing different sperm concentrations for optimizing cooled semen use in the dog

The use of shipping canine semen for artificial insemination has bloomed over the last 20 years. This allows for the spread of genetic material while overcoming geographical or time-related challenges. The optimal sperm concentration for cooled semen transport in the dog is unknown. Often canine semen is extended 1:3–5 vol:vol without standardized sperm concentrations for cooled shipment. We compared different sperm concentrations for cooled storage and hypothesized that lower concentrations would result in better semen quality. Semen was collected from healthy client-owned dogs (n = 8). Individual ejaculates were divided into a control aliquot (CON) extended 1:3 vol:vol with a commercial extender. The remaining sample was centrifuged and extended to 200 ×106 sperm/ml (C200), then serially diluted to 100, 50, and 25 ×106 sperm/ml concentrations (C100-C25). Aliquots were cooled for 24 h and then centrifuged and re-extended. Sperm concentration, plasma membrane integrity (PMI, %), motility (subjective total, STM; computer-assisted sperm analysis (CASA) total and progressive, TM, PM; %), and normal morphology (NM, %) were assessed in raw semen (T0), post-extension (T1), after 24 h of cooling (T2), and after processing at 24 h (T3). Cooling resulted in significant declines in STM and NM for all groups and in decreased PMI for CON and C25-50. After cooling (at T2), PMI was significantly lower for C25 compared with all the groups and higher for CON compared with C25-100 (p ≤ 0.038). Processing and re-extension after cooling further decreased the spermiogram parameters. At T3, PMI for CON was similar to C200 but significantly higher than C25-100, while C25 had the lowest PMI. For motility parameters and NM, C25 performed worse than all or most of the other groups. Comparing CON at T3 with C25-200 at T2, PMI, STM, and NM for CON were significantly lower than C25-200, C200, and C100-200, respectively. In conclusion, our results show that cooling canine semen for 24 h at 200 ×106 sperm/ml final concentration after processing or extending 1:3 vol:vol without centrifugation is preferred based on the highest PMI. If volume restrictions apply, processing raw semen and extending to the desired volume with higher sperm concentrations at the collection facility is superior to centrifugation and volume adjustment after 24 h of cooled storage.
Beryllium anomalies in solar-type field stars

We present a study of beryllium (Be) abundances in a large sample of field solar-type dwarfs and sub-giants spanning a large range of effective temperatures. The Be abundances, computed using a very uniform set of stellar parameters and near-UV spectra obtained with 3 different instruments, are used to study the depletion of this light element. The analysis shows that Be is severely depleted for F stars, as expected by the light-element depletion models. However, we also show that beryllium abundances decrease with decreasing temperature for stars cooler than ∼6000 K, a result that cannot be explained by current theoretical models including rotational mixing, but that is, at least in part, expected from the models that take into account internal wave physics. In particular, the light element abundances of the coolest and youngest stars in our sample suggest that Be, as well as lithium (Li), has already been burned early during their evolution. Furthermore, we find strong evidence for the existence of a Be-gap for solar-temperature stars. The analysis of Li and Be abundances in the sub-giants of our sample also shows the presence of one case that has still detectable amounts of Li, while Be is severely depleted. Finally, we compare the derived Be abundances with Li abundances derived using the same set of stellar parameters. This gives us the possibility to explore the temperatures for which the onset of Li and Be depletion occurs.
Mesenchymal Stem Cells from Familial Alzheimer’s Patients Express MicroRNA Differently

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder and the predominant form of dementia globally. No reliable diagnostic, predictive techniques, or curative interventions are available. MicroRNAs (miRNAs) are vital to controlling gene expression, making them valuable biomarkers for diagnosis and prognosis. This study examines the transcriptome of olfactory ecto-mesenchymal stem cells (MSCs) derived from individuals with the PSEN1(A431E) mutation (Jalisco mutation). The aim is to determine whether this mutation affects the transcriptome and expression profile of miRNAs and their target genes at different stages of asymptomatic, presymptomatic, and symptomatic conditions. Expression microarrays compare the MSCs from mutation carriers with those from healthy donors. The results indicate a distinct variation in the expression of miRNAs and mRNAs among different symptomatologic groups and between individuals with the mutation. Using bioinformatics tools allows us to identify target genes for miRNAs, which in turn affect various biological processes and pathways. These include the cell cycle, senescence, transcription, and pathways involved in regulating the pluripotency of stem cells. These processes are closely linked to inter- and intracellular communication, vital for cellular functioning. These findings can enhance our comprehension and monitoring of the disease’s physiological processes, identify new disorder indicators, and develop innovative treatments and diagnostic tools for preventing or treating AD.