Miracle-dz/UniFAR-FTUs huggingface dataset:
Development of a Vascularized Human Skin Equivalent with Hypodermis for Photoaging Studies

Photoaging is an important extrinsic aging factor leading to altered skin morphology and reduced function. Prior work has revealed a connection between photoaging and loss of subcutaneous fat. Currently, primary models for studying this are in vivo (human samples or animal models) or in vitro models, including human skin equivalents (HSEs). In vivo models are limited by accessibility and cost, while HSEs typically do not include a subcutaneous adipose component. To address this, we developed an “adipose-vascular” HSE (AVHSE) culture method, which includes both hypodermal adipose and vascular cells. Furthermore, we tested AVHSE as a potential model for hypodermal adipose aging via exposure to 0.45 ± 0.15 mW/cm2 385 nm light (UVA). One week of 2 h daily UVA exposure had limited impact on epidermal and vascular components of the AVHSE, but significantly reduced adiposity by approximately 50%. Overall, we have developed a novel method for generating HSE that include vascular and adipose components and demonstrated potential as an aging model using photoaging as an example.
QUALITY EVALUATION OF CHEVON PATTIES FORTIFIED WITH DIETARY FIBRE

To investigate the effect of finger millet flour (FMF) on physico-chemical, sensory, colour profile and texture quality attributes of goat meat patties, four preparations were made by replacing the amount of meat in the product formulation with incorporation of FMF viz., 0% (control), 2% (T1), 4% (T2) and 6% (T3). The emulsion stability and cooking yield improved significantly (P<0.05) in all the treatments than control and the highest value was recorded for patties with 6% FMF. In the cooked product pH, water activity (aw), moisture, ash content, moisture-protein ratio and fat retention increased significantly (P<0.05) whereas protein and fat contents decreased significantly (P<0.05) in patties with FMF as compared to the control. Fibre and calcium contents of the patties with FMF increased significantly (P<0.05) in a dose dependent manner. Dimensional parameters were better maintained in the FMF incorporated patties than control. The instrumental texture profile attributes like hardness, springiness, stringiness, chewiness and gumminess decreased significantly (P<0.05) in FMF incorporated patties, whereas cohesiveness and resilience were comparable to the control. The sensory attributes viz., colour/appearance, flavour, juiciness and overall quality improved significantly (P<0.05) in patties with different levels of FMF. It was concluded that goat meat patties with improved cooking yield, textural profile and acceptable sensory attributes, can be successfully developed with the incorporation of 4.0% FMF.
Formation and Quasi-Periodic Behavior of Outer Spiral Rainbands in a Numerically Simulated Tropical Cyclone*

AbstractThe formation and quasi-periodic behavior of outer spiral rainbands in a tropical cyclone simulated in the cloud-resolving tropical cyclone model version 4 (TCM4) are analyzed. The outer spiral rainbands in the simulation are preferably initiated near the 60-km radius, or roughly about 3 times the radius of maximum wind (RMW). After initiation, they generally propagate radially outward with a mean speed of about 5 m s−1. They are reinitiated quasi-periodically with a period between 22 and 26 h in the simulation. The inner spiral rainbands, which form within a radius of about 3 times the RMW, are characterized by the convectively coupled vortex Rossby waves (VRWs), but the formation of outer spiral rainbands (i.e., rainbands formed outside a radius of about 3 times the RMW) is much more complicated. It is shown that outer spiral rainbands are triggered by the inner-rainband remnants immediately outside the rapid filamentation zone and inertial instability in the upper troposphere. The preferred rad.
Aging Affects the Efficacy of Platelet-Rich Plasma Treatment for Osteoarthritis

Objective Despite the increased use of platelet-rich plasma in the treatment of osteoarthritis, whether and how age of the platelet-rich plasma donor affects therapeutic efficacy is unclear. Design In vitro, male osteoarthritic human chondrocytes were treated with platelet-rich plasma from young (18–35 yrs) or old (≥65 yrs) donors, and the chondrogenic profile was evaluated using immunofluorescent staining for two markers of chondrogenicity, type II collagen and SOX-9. In vivo, we used a within-subjects design to compare Osteoarthritis Research Society International scores in aged mouse knee joints injected with platelet-rich plasma from young or old individuals. Results In vitro experiments revealed that platelet-rich plasma from young donors induced a more youthful chondrocyte phenotype, as evidenced by increased type II collagen (P = 0.033) and SOX-9 expression (P = 0.022). This benefit, however, was significantly blunted when cells were cultured with platelet-rich plasma from aged donors. Accordingly, in vivo studies revealed that animals treated with platelet-rich plasma from young donors displayed a significantly improved cartilage integrity when compared with knees injected with platelet-rich plasma from aged donors (P = 0.019). Conclusions Injection of platelet-rich plasma from a young individual induced a regenerative effect in aged cells and mice, whereas platelet-rich plasma from aged individuals showed no improvement in chondrocyte health or cartilage integrity.
An Empirical Model of the Sporadic E Layer Intensity Based on COSMIC Radio Occultation Observations

Ionospheric sporadic E layers are common phenomena occurring in the ionospheric E region altitude (∼90–120 km) with much higher electron density. The lack of a large amount of sporadic E layer intensity observation on a global scale restrains the construction of global modeling of sporadic E layer intensity. Recent studies reveal that radio occultation observation can be used for sporadic E layer intensity inversion. In this paper, a low‐mid latitude empirical model of sporadic E layer critical frequency is constructed based on Constellation Observing System for Meteorology, Ionosphere, and Climate radio occultation data during 2007–2012. Model results show good accordance with ionosonde observations over 16 stations in different latitudes. In general, the model has a good performance in simulating the climate variation features of sporadic E layer intensity with averaged deviation 0.23 MHz which indicates a slight overestimation. Besides, spatial and temporal variations simulated by the model are also analyzed and show good agreement with known sporadic E layer features. However, the empirical may be only suitable for climate research at present and potential methods to improve the model will be investigated in the latter research.
Application of quantum dots in solid state lighting

In this study, binary CdSe and ternary Zn0.5Cd0. 5Se quantum dots (QDs) with monochromatic light are blended with conventional phosphors and those monochromatic lights of Zn0.5Cd0. 5Se QDs are also mixed together and then packaged as remote type. Besides, white light CdSe QD are used alone to fabricate white light-emitting diode (LED). We have demonstrated that the color rendering index (CRI) and luminous efficacy can be improved by blending conventional phosphors with QDs. The Zn0.5Cd0. 5Se QDs incorporated with yellow phosphors have better device performance and optical properties. Zn0.5Cd0. 5Se QDs with different emission wavelength are blended with each other. The result reveals that mixing ratios and photoluminescence efficiency (PLE) between different colors of QDs are important factors. When white CdSe QD is excited by ultraviolet LED (UV-LED) without mixing multi-colors of phosphor, high CRI can be obtained for CdSe-based white LED.
Improvement of New Gyro-Sensor and Accelerometer Device Used for Walking and Running

The purposes of this study were to recalibrate a new motion sensor wristband (ViM sports memory: ViM) to metabolic equivalents (METs) during walking and running, and to examine the cross-validity of the recalibration model. Forty-five healthy Japanese (23 males and 22 females) voluntarily participated in this study. The participants were divided into two groups: a recalibration group (16 males and14 females) and a cross-validity group (7 males and 8 females). The participants performed 5 min of treadmill walking at 3.6, 4.8, and 6.0 km/h, and treadmill running at 7.2, and 9.6 km/h. The ViM was placed on the non-dominant wrist. Simultaneous measurements of the ViM and an indirect calorimeter (IC) were continuously recorded during all exercises. The recalibration models were calculated for males and females from data of the recalibration group using general linear mixed model. The cross-validity was examined by correlation coefficients, repeated ANOVA, and paired t-test adjusted by Bonferroni's method. In the recalibration group, the recalibration models showed high determination coefficients (male: R2=0.74, SEE=1.51 METs; females: R2=0.84, SEE=1.16 METs). In the cross-validation group, there were significant correlation coefficients at 3.6, 4.8, 6.0, and 9.6 km/h (r>=0.56, p 0.185) at any speed. These results showed that the recalibration model improved the validity and accuracy of the ViM.
Fecal Luminal Factors from Patients with Gastrointestinal Diseases Alter Gene Expression Profiles in Caco-2 Cells and Colonoids

Previous in vitro studies have shown that the intestinal luminal content, including metabolites, possibly regulates epithelial layer responses to harmful stimuli and promotes disease. Therefore, we aimed to test the hypothesis that fecal supernatants from patients with colon cancer (CC), ulcerative colitis (UC) and irritable bowel syndrome (IBS) contain distinct metabolite profiles and establish their effects on Caco-2 cells and human-derived colon organoids (colonoids). The metabolite profiles of fecal supernatants were analyzed by liquid chromatography–mass spectrometry and distinguished patients with CC (n = 6), UC (n = 6), IBS (n = 6) and healthy subjects (n = 6). Caco-2 monolayers and human apical-out colonoids underwent stimulation with fecal supernatants from different patient groups and healthy subjects. Their addition did not impair monolayer integrity, as measured by transepithelial electrical resistance; however, fecal supernatants from different patient groups and healthy subjects altered the gene expression of Caco-2 monolayers, as well as colonoid cultures. In conclusion, the stimulation of Caco-2 cells and colonoids with fecal supernatants derived from CC, UC and IBS patients altered gene expression profiles, potentially reflecting the luminal microenvironment of the fecal sample donor. This experimental approach allows for investigating the crosstalk at the gut barrier and the effects of the gut microenvironment in the pathogenesis of intestinal diseases.
In situ multiphase fluid experiments in hydrothermal carbon nanotubes

Hydrothermal multiwall closed carbon nanotubes are shown to contain an encapsulated multiphase aqueous fluid, thus offering an attractive test platform for unique in situ nanofluidic experiments in the vacuum of a transmission electron microscope. The excellent wettability of the graphitic inner tube walls by the aqueous liquid and the mobility of this liquid in the nanotube channels are observed. Complex interface dynamic behavior is induced by means of electron irradiation. Strong atomic-scale interactions between the entrapped liquid phase and the wetted terminated graphite layers are revealed by means of high-resolution electron microscopy. The documented phenomena in this study demonstrate the potential of implementing such tubes in future nanofluidic devices.
3C 317 : an amorphous radio source in the cooling flow cluster Abell 2052

We have observed the radio source 3C 317 in the X-ray cooling flow cluster A2052 using the VLA at wavelengths 90, 20, 6, and 3.6 cm. Unlike most moderate-power extragalactic radio sources, 3C 317 is characterized by a compact core and an amorphous halo with an angular size of 75″×45″. The spectrum of the halo emission is unusually steep (α 20/90cm ∼−1.5 and α 6/20cm ∼−1.9). Surrounding the compact radio core at the center of the galaxy, a bipolar structure has been observed indicating that an outflow may have been initially collimated to some degree. However, no well-collimated jets have been detected with a resolution of 0. ″3
Plasmon-induced transparency in twisted Fano terahertz metamaterials

We investigate the effect of tweaking the quality (Q) factor of split ring resonators in a coupled state, giving rise to plasmonic induced transparency (PIT) which has two distinct, individually engineered resonance modes. The Q factor and the amplitude of each resonance are tuned by twisting them mutually in the unit cell consisting of a subradiant and a superradiant resonator. We experimentally observe that introducing a gradual twist in the three U-shape resonators has a dramatic impact on the PIT spectral response, leading to the disappearance of the transparency peak beyond a certain critical degree of twist. This mainly happens due to the change in the in-plane coupling between the resonators as well the variation in coupling of the twisted resonators with the incident electric field. Further investigation based on the Fano model provides good agreement with the experimental results. The scheme presented here for controlling the Q factor of each resonator in the coupled regime is a unique way to tune the PIT response in terahertz metamaterials and can be easily scaled across the entire electromagnetic spectrum.
Role of Candida albicans in Oral Carcinogenesis

Oral carcinogenesis is also dependent on the balance of the oral microbiota. Candida albicans is a member oral microbiota that acts as an opportunistic pathogen along with changes in the epithelium that can predispose to premalignancy and/or malignancy. This systematic review uses the Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines to analyze the role of Candida albicans in the process of oral carcinogenesis. Eleven articles qualified inclusion criteria, matched keywords, and provided adequate information about the carcinogenesis parameters of Candida albicans in oral cancer. Candida albicans in oral carcinogenesis can be seen as significant virulent factors for patients with oral squamous cell carcinoma (OSCC) or potentially malignant disorder (OPMD) with normal adjacent mucosa. Candida albicans have a role in the process of oral carcinogenesis concerning morphological phenotype changes in cell structure and genotype and contribute to the formation of carcinogenic substances that can affect cell development towards malignancy.
Reducing Misconception of Force Concepts Through Learning Conceptual Change Model with Cognitive Conflict Approach

This type of research is quantitative research that aims to reduce students' misconceptions through learning a conceptual change model with a cognitive conflict approach (CCM-CCA). The population in this study were students of the Physics Education Study Program, the University of Mataram, and students of the Surabaya State University Science Education Study Program. The sample in this study amounted to 56 second-semester students at both universities, each of which amounted to 29 people. The CCM-CCA used has been validated in Focus Group Discussion (FGD) activities and has been declared valid in content and construct so that it is appropriate to use. Data in this study were obtained through misconceptions tests, observations of conceptual changes and cognitive conflicts, and the interview process. Data analysis in this study used descriptive analysis by looking at the comparison of the percentage of students who had misconceptions before and after being given treatment and analyzing the level of cognitive conflict. The results of this study indicate that the CCM-CCA learning model is effective in reducing student misconceptions. Conceptual changes and cognitive conflicts that occur in students are included in the high and very high categories, and the results of structured interviews show that students experience 4 thought processes while learning CCM-CCA which helps students to change their conceptions from initially experiencing misconceptions to understanding scientific concepts.
Clinical outcome of three different types of posterior all-ceramic crowns. A 3-year follow-up of a multicenter, randomized, controlled clinical trial.

PURPOSE To assess and compare the clinical outcomes of three different types of all-ceramic posterior monolithic tooth-supported crowns. MATERIALS AND METHODS A total of 71 patients received 90 all-ceramic crowns randomized to be either high-translucency zirconia (ZC), high-translucency zirconia with a partial buccal veneer (ZC-V), or lithium disilicate glass-ceramic (LDS). All treatments were performed by four general dentists. Choice of material was blinded. Baseline and subsequent annual evaluation were based on modified California Dental Association (CDA) criteria. A questionnaire was used to include patient-reported outcomes and to compare them to the crown quality rating performed by dentists. RESULTS A total of 66 patients with 84 crowns were examined after 3 years. The survival rate was 98.8%. No crowns fractured during the observation period. One ZC-V crown failed due to loss of retention, and three complications were noted: loss of retention occurred in one ZC crown, and two ZC crowns needed to be endodontically treated. There was no significant difference between the different crowns regarding marginal integrity, surface, or anatomical form. Both patients and examining dentists rated the crowns favorably regarding esthetics, patients more than dentists. CONCLUSION Posterior lithium disilicate glass-ceramic crowns and translucent zirconia crowns with or without a partial buccal veneer show excellent and promising clinical outcomes from a short-term perspective. Patients and dentists rate the restorations favorably concerning esthetics and function.
The dynamics of Australian stock indices and commodities based on MGARCH-DCC and wavelet techniques

Abstract This paper aims to investigate the extent of hedging and diversification opportunities available for an Australian investor who holds a portfolio consisting of Australian conventional and Islamic indices, crude oil, gold, Bitcoin, and the Australia–US exchange rate of daily data from 2011 to 2021. The relevant time-varying and time-scale dependent techniques, such as MGARCH dynamic conditional correlation (MGARCH-DCC), continuous wavelet transform (CWT), and maximal overlap discrete wavelet transform (MODWT) are employed to discern the correlation and volatilities of the variables. The paper’s unique contribution lies in unveiling an Australian investor’s diversification opportunities of a portfolio containing Bitcoin, gold, oil, Islamic indices, conventional indices, and exchange rates. Findings from MGARCH-DCC analysis suggest that Bitcoin is the least correlated variable. However, investors may be discouraged from choosing Bitcoin as a diversification instrument due to its high volatility. The evidence further suggests that Australian investors may benefit from diversification with gold. Nonetheless, the CWT result shows that the diversification benefits effects will last for a holding period no longer than 64 days. Our research findings tend to indicate the importance of finding diversification opportunities for investors with heterogeneous investment holdings over various periods by utilising relatively advanced techniques.
Evolutionary sequences for red giant stars

A set of 46 evolutionary sequences has been computed for stars ascending the red giant branch for the first time. These red giant sequences, extending from the subgiant branch to the onset of helium burning within the core, cover the following ranges in the helium abundance Y, the heavy-element abundance Z, and the mass M:0.10< or =Y< or =0.40, 0.00001< or =Z< or =0.04, and 0.70< or =M< or =2.20 M/sub sun/. Combinations of these values appropriate to galactic and globular clusters have been emphasized. The effects of varying the rate of neutrino emission from zero to twice the normally adopted value have also been investigated. Except for one sequence, helium ignition occurred under degenerate conditions. Extensive tabulations of the numerical results are provided, and from these data the systematic dependences of red giant properties on composition and mass can be determined. For (M,Y,Z) = (0.80,0.30,0.001), the core mass M/sub c/ at the flash and its derivatives are given by M/sub c/=0.474 M/sub sun/, partialM/sub c//partialY=-0.24, partialM/sub c//partial logZ=-0.007, and partialM/sub c//partialM=-0.038. These derivatives depend significantly on the composition and mass. When neutrino emission is neglected, M/sub c/ decreases by 0.03 M/sub sun/. The enhanced rates of neutrino emission duemore » to neutral current interactions increase by M/sub c/ by about 0.007 M/sub sun/. The temperature inversion produced by the neutrino cooling of the core leads to a noncentral flash in almost all of the sequences. The flash site shifts outward in mass with decreases in Y of M or increases in the rate of neutrino emission. For many of the sequences a temporary period of decreasing surface luminosity occurs during the early part of the red giant phase. This luminosity drop is more prominent at low values of Y and large values of Z. The morphology of the red giant tracks in the H-R diagram is discussed. « less
The Resident VIEW in Community-Based Care Residential Settings

The Resident VIEW is a measure of person-centered care (PCC) from residents’ perspectives and was previously studied in nursing homes. The current study presents descriptive data for the Resident VIEW in community-based care settings including assisted living, residential care (AL/RC), and adult foster homes (AFH). Using a two-stage sampling design, we recruited 31 AL/RC and 119 AFH in Oregon and completed face-to-face structured interviews with 227 and 195 residents, respectively. Residents provided ratings for both the importance of and their experience with 66 items that tapped into PCC practices in eight domains. Results are provided for each item, many of which are significantly associated with greater quality of life, better resident satisfaction, and fewer depressive symptoms, especially in the domains of personalized care and being treated like a person. Incongruence between importance and experience ratings indicate many residents experience unmet needs across multiple domains. The Resident VIEW performed well in different types of settings, providing an important tool for researchers and providers who wish to learn about the PCC experience from residents’ points of view.
A class of weighted multivariate distributions related to doubly truncated multivariate t-distribution

This article introduces a class of weighted multivariate t-distributions, which includes the multivariate generalized Student t and multivariate skew t as its special members. This class is defined as the marginal distribution of a doubly truncated multivariate generalized Student t-distribution and studied from several aspects such as weighting of probability density functions, inequality constrained multivariate Student t-distributions, scale mixtures of multivariate normal and probabilistic representations. The relationships among these aspects are given, and various properties of the class are also discussed. Necessary theories and two applications are provided.