Miracle-dz/UniFAR-FTUs huggingface dataset:
{[μ‐N,N′‐Bis­(salicyl­idene)‐2,2′‐di­methyl‐1,3‐propane­di­amine](piperidine)copper(II)}di­bromo­zinc(II)

In the crystal structure of the dinuclear title compound, [CuZnBr2(C19H22N2O2)(C5H11N)], the CuII ion has a distorted square-pyramidal coordination involving two iminic N and two phenolic O atoms of the N,N′-bis­(salicyl­idene)-2,2′-di­methyl-1,3-propane­diaminate (SALPD2− or C17H16N2O22−) ligand and one N atom of the piperidine group. The coordination around the ZnII ion is distorted tetrahedral, with two O atoms of the SALPD2− ligand and two bromide ions. The Zn—Br bond lengths are 2.3309 (9) and 2.3508 (10) A. The Cu⋯Zn distance is 3.0800 (9) A.
(E)-1-Di­phenyl­silyl-2-tri­phenyl­silyl­ethene

In the title compound, C32H28Si2, the configuration at the C=C double bond is E [−179.1 (2)°], and two Si atoms in di­phenyl­silyl and tri­phenyl­silyl groups bridged by the C=C double bond [1.292 (5) A] retain the overall tetrahedral environment of the C and H atoms with an average Si—C bond length of 1.864 (1) A and Si—H length of 1.35 (3) A.
N-(2-Bromo-4-methylphenyl)naphthaldimine

Molecules of the title compound [1-(2-bromo-4-methylphenyliminomethyl)-2-naphthol, C18H14BrNO] are not exactly planar. Each contains a strong intramolecular N⋯H—O hydrogen bond between the amino and hydroxyl groups [2.553 (4) A].
Isolation of Antibiotic 3R,5R-Dihydroxyhexanoate Polymers From Endophytic Fungi

The extracts of two isolates in our library of fungal endophytes, Annulohypoxylon multiforme (TC2-046) from the medicinal plant Juniperus communis and a sterile filamentous isolate (KP1-131DD) from the marine alga Scytosiphon lomentaria, displayed similar antimicrobial bioactivity profiles with notable high activity against Staphylococcus aureus. Bioassay-guided fractionation led to the isolation of poly(3R,5R-dihydroxyhexanoic acid) oligomers ranging from the trimer to the 29-mer that exhibited significant and selective inhibition of S. aureus and Mycobacterium tuberculosis H37Ra in vitro.
Interventional treatment for type 2 diabetes

Obesity and type 2 diabetes are currently the most serious health problems in developed and developing countries. According to standards of treatment of diabetes, especially with obesity, weight reduction is an essential element of therapy. However, to obtain a decrease in weight and its maintenance is often very difficult. This is due to the limited effectiveness of the available methods and to the reluctance of patients to maintain the rigors of dietary and physical activity. On the other hand, it is quite well known already that bariatric surgery is an effective way to achieve a significant reduction in body weight. Now several million such surgical interventions has already been carried out all over the world. Since the introduction of the laparoscopic technique, they are getting more safe, effective, and the variety of types of operation allows to adjust the appropriate method individually for each patient. Review briefly presents the different types of operations, the rules for eligibility and preparing patients for surgery, as well as the most important problems which the physician should remember in care about the patient after surgery. These are also an alternative to surgery, less invasive methods of intervention treatment of diabetes and obesity described.
Brillouin light scattering uncertainty preliminary estimation

This paper aims to give a preliminary way to estimate uncertainty on the frequency peak between 2 and 150 GHz determined by Brillouin Scattering Stimulation and corresponding to the speed of phonons inside a material excited by a 532 nm wavelength laser. The guideline follows the Guide to the Expression of Uncertainty in Measurement. A first estimation indicates that the speed of the phonons can be known at 2 to 5 % at 2 sigmas.
First principles study electronic and optical properties of LaBr3 and LaBr3:Ce crystal

First-principles calculations based on the density function theory (DFT) are implemented to explore the effect of Ce doping on the electronic structure and optical properties of LaBr3 crystals using generalized gradient approximation (GGA) +U. And band structure, density of states and optical properties are discussed. Due to the transition of Ce3+ ion from 4f-orbital to 5d-orbital, the band gaps of LaBr3:Ce (0.63 eV) is narrower than that of LaBr3 (3.569 eV), which produce more visible light in the same range of irradiated energy. Otherwise, the absorption spectrum (15.6 μm-1) and reflection index (less than 12%) of LaBr3:Ce are smaller than LaBr3 (20 μm-1, less than 15%, respectively), leading to transmit more visible light. The research shows reason that Ce doping can improve the luminescence performance of LaBr3 scintillators and the results are compared with the available experimental data.
Wind impact on the plume development and suspended matters transport according to optical scanners

It is studied the plume response, formed by the Danube River in the North-Western part of the Black Sea, to the wind forcing. Two cases are considered: the wind of the N-NE and S-SW directions. The plume evolution, alongshore flow formation and suspended matter transfer are analyzed on the base of satellite data at a wavelength of 551 nm for these two wind forcing scenarios. The coastal current dynamics and formation of Danube plume and salinity front are studied on the basis of 3D numerical model which was adapted to the conditions of the North-Western shelf. The obtained results from the satellite data analysis are compared with results of numerical simulation of plume formation under the action of wind in order to estimate the model sensitivity to variations of the wind direction and of the wind speed magnitude.
Spectral transparency of the near-surface layer of the marine and coastal atmosphere using MaexPro aerosol model

The effect of meteorological parameters on the spectral aerosol extinction coefficients ε(λ) in the near-surface layer of the marine and coastal atmosphere is studied. The results obtained are of interest both in the calculations of radiative characteristics of the atmosphere, and in the calculations of energy properties of the optical signals in optical-electronic devices of different purposes in the wavelength range ▵λ = (0.2 – 16) μm. The MaexPro model is shown to calculate adequately ε(λ) and concentration of sea salt aerosol (SSA) particles for different wind regimes, fetches, and humidity. The calculated ε(λ) profiles well agree with experimental data and with calculations using ANAM code. The results thus obtained give a new explanation for the effect of decreasing transparency, manifested in coastal zone, and make it possible to account for indirectly the type (marine or coastal) of air mass.
5-Month Herbal Therapy and Complete Sero-Reversion with Recovery in an Adult HIV/AIDS Patient

Herbal remedies contain active ingredients which are parts of plants or plant materials, or combinations used to treat a multitude of ailments throughout the world. It was estimated that most Africans use herbal remedies [1]. The severity of illnesses, availability and low cost prompted many to seek for alternative therapies outside orthodox medicines. This explains why some HIV infected patients seek for herbal therapies due to its un-curable nature.
Sonic hedgehog signaling in epithelial tissue development

The Sonic hedgehog (SHH) signaling pathway is essential for embryonic development and tissue regeneration. The dysfunction of SHH pathway is involved in a variety of diseases, including cancer, birth defects, and other diseases. Here we reviewed recent studies on main molecules involved in the SHH signaling pathway, specifically focused on their function in epithelial tissue and appendages development, including epidermis, touch dome, hair, sebaceous gland, mammary gland, tooth, nail, gastric epithelium, and intestinal epithelium. The advance in understanding the SHH signaling pathway will give us more clues to the mechanisms of tissue repair and regeneration, as well as the development of new treatment for diseases related to dysregulation of SHH signaling pathway.
Medical Scribes in the Emergency Department: The Scribes’ Point of View

Background: Studies report the benefit of medical scribes in the emergency department on patient throughput, clinical documentation, patient outcomes, and provider and patient satisfaction. However, studies are silent on the benefits of being a scribe for premedical and medical students. Methods: The senior author interviewed 8 scribes who were applying for medical school and 9 medical students who had been scribes prior to medical school. Discussion was prompted on undergraduate education; scribe recruitment and training; career intentions; experience as a scribe; and the value of being a scribe to themselves, to the doctors with whom they worked, and to the hospital where they were employed. Results: The typical scribe had become a scribe to support his or her chances of entry into medical school. Those already in medical school were not convinced that this experience had actually made a difference in their acceptance. All 17 scribes were emphatic that the role had benefitted them in other ways, specifically, by learning medical terminology, observing communication between doctor and patient, and understanding the practice of medicine in an emergency department. For many scribes, the experience reinforced the desire to become a doctor. The scribes recognized their value in the areas of process and finance. They also recognized that many doctors, particularly those working in academic health centers, derived satisfaction from the training and mentoring that they offered. Conclusion: Scribes perceive the role of a scribe to be highly valuable in terms of their career decision making and future medical education.
Incidence of Deep Venous Thrombosis Associated With Proximal Hamstring Rupture

Background: Rates of deep venous thrombosis (DVT) have been studied for most common orthopaedic injuries. However, rates and risk factors have not been published for proximal hamstring injuries. Purpose: To determine the incidence of symptomatic DVT associated with proximal hamstring rupture and associations with prophylactic anticoagulation. Study Design: Case series; Level of evidence, 4. Methods: Inclusion criteria included all complete and, in a separate cohort, partial proximal hamstring ruptures treated by the senior author from 2007 through 2018 with at least 8 weeks of follow-up. Tendinopathy without tear was excluded. No DVT screening was performed. Charts of patients with symptomatic DVT were reviewed for the treatment method, the presence of imaging-confirmed DVT or pulmonary embolism, and risk factors for DVT. No patients received postinjury DVT prophylaxis. Surgical patients were routinely instructed to take aspirin (325 mg bid) or apixaban (2.5 mg bid) for 4 weeks. Patients with risk factors for DVT received enoxaparin (40 mg daily) for 2 weeks followed by aspirin (325 mg bid) for 2 weeks. Results: A total of 144 complete proximal hamstring ruptures were included: 132 treated operatively and 12 treated nonoperatively. There were 10 DVTs associated with the injury, for an overall rate of 6.9%. Five of the DVTs were diagnosed preoperatively in patients who had not received DVT prophylaxis; the other 5 were diagnosed postoperatively in patients on DVT prophylaxis. Six of the 10 DVTs had identifiable risk factors. All patients with postoperatively diagnosed DVTs were on prophylactic aspirin or enoxaparin. In the partial proximal hamstring rupture cohort of 114 ruptures, there were no DVTs. Conclusion: There is a high incidence of DVT associated with complete proximal hamstring ruptures (6.9%) despite many patients receiving DVT prophylaxis. This is substantially higher than that in other lower extremity injuries. Clinicians should have a high index of suspicion for DVT after these injuries, and postinjury DVT prophylaxis may be warranted.
New classes of topological crystalline insulators having surface rotation anomaly

Real-space constructions for C2,4,6-rotation and time-reversal symmetries. (a-c) show in the absence of translation symmetries, the minimal constructions of twofold, fourfold and six-fold rotation symmetry protected topological states in three dimensions, where each plane is a two-dimensional internal symmetry protected topological state of either bosons or fermions. If it is a two-dimensional topological insulator, the resultant states are the topological crystalline insulators studied in the text. (d-f) are simple extensions of the
Contributions of the Capsule and Labrum to Hip Mechanics in the Context of Hip Microinstability

Background: Hip microinstability and labral pathology are commonly treated conditions with increasing research emphasis. To date, there is limited understanding of the biomechanical effects of the hip capsule and labrum on controlling femoral head motion. Purpose/Hypothesis: The purpose of this study was to determine the relative role of anterior capsular laxity and labral insufficiency in atraumatic hip microinstability. Our hypotheses were that (1) labral tears in a capsular intact state will have a minimal effect on femoral head motion and (2) the capsule and labrum work synergistically in controlling hip stability. Study Design: Controlled laboratory study. Methods: Twelve paired hip specimens from 6 cadaveric pelvises (age, 18-41 years) met the inclusion criteria. Specimens were stripped of all soft tissue except the hip capsule and labrum, then aligned, cut, and potted using a custom jig. A materials testing system was used to cyclically stretch the anterior hip capsule in extension and external rotation, while rotating about the mechanical axis of the hip. Labral insufficiency was created with a combined radial and chondrolabral tear under direct visualization. A motion tracking system was used to record hip internal-external rotation and displacement of the femoral head relative to the acetabulum in the anterior-posterior, medial-lateral, and superior-inferior directions. Testing variables included baseline, postventing, postcapsular stretching, and postlabral insufficiency. Results: When comparing the vented state with each experimental pathologic state, increases in femoral head motion were noted in both the capsular laxity state and the labral insufficiency state. The combined labral insufficiency and capsular laxity state produced statistically significant increases (P < .001) in femoral head translation compared with the vented state in all planes of motion. Conclusion: Both the anterior capsule and labrum play a role in hip stability. In this study, the anterior hip capsule was the primary stabilizer to femoral head translation, but labral tears in the setting of capsular laxity produced the most significant increases in femoral head translation. Clinical Relevance: This study provides a physiologic biomechanical assessment of the hip constraints in the setting of hip microinstability. It also sheds light on the importance of the hip capsule in the management of labral tears. Our study demonstrates that labral tears in isolation provide minimal changes in femoral head translation, but in the setting of a deficient capsule, significant increases in femoral head translation are seen, which may result in joint-related symptoms.
The Neuroprotective Effect of Amitriptyline on Radiation-Induced Impairment of Hippocampal Neurogenesis

The radioprotective effect of amitriptyline, an inhibitor of acid sphingomyelinase (ASMase), on radiation-induced impairment of hippocampal neurogenesis, loss of interneuron, and animal weight changes was investigated in BALB/c mice by immunostaining of biomarkers for cell division (Ki67), immature neurons (doublecortin or DCX), and interneurons (parvalbumin or PV) in the dentate gyrus (DG) of hippocampus. The results indicated that preirradiation (with 10 mg/kg, 2 times per day, for 7 consecutive days) or postirradiation (with 10 mg/kg, 2 times per day, for 14 consecutive days) treatment (pretreatment or posttreatment) with intraperitoneal injection of amitriptyline prevented the loss of newly generated neurons, proliferating cells, and interneurons in the subgranular zone of the DG. At the molecular level, pretreatment or posttreatment inhibited the expression of sphingomyelin phosphodiesterase 1 (SMPD1) gene which codes for ASMase. The pretreatment for 7 days also prevented radiation-induced weight loss from 2 to 3 weeks, but not within 1 week after irradiation. On the other hand, the posttreatment with amitriptyline for 14 days could improve animal weight gain from 4 to 6 weeks after irradiation. The present study suggests that amitriptyline may be a promising candidate radio-neuroprotective drug to improve radiation-induced impairment of hippocampal neurogenesis and relevant neurological and neuropsychological disorders.
Active role of elongation factor G in maintaining the mRNA reading frame during translation

This study shows how elongation factor G helps to maintain the mRNA reading frame during protein synthesis on the ribosome. During translation, the ribosome moves along the mRNA one codon at a time with the help of elongation factor G (EF-G). Spontaneous changes in the translational reading frame are extremely rare, yet how the precise triplet-wise step is maintained is not clear. Here, we show that the ribosome is prone to spontaneous frameshifting on mRNA slippery sequences, whereas EF-G restricts frameshifting. EF-G helps to maintain the mRNA reading frame by guiding the A-site transfer RNA during translocation due to specific interactions with the tip of EF-G domain 4. Furthermore, EF-G accelerates ribosome rearrangements that restore the ribosome’s control over the codon-anticodon interaction at the end of the movement. Our data explain how the mRNA reading frame is maintained during translation.
IGFBP-2 acts as a tumour suppressor and plays a role in determining chemosensitivity in bladder cancer cells

There are mixed reports on the role that IGFBP-2 plays in cancer progression, with some indicating a tumour suppressive role and others showing that IGFBP-2 may act as an oncogene. These apparent contradictions may be context and tissue specific. In this study we determined the role that IGFBP-2 played on the phenotype and chemosensitivity of a selection of bladder cancer cell lines and investigated how the abundance of IGFBP-2 was regulated. We found that IGFBP-2 was more abundant in the epithelial bladder cancer cells, RT4 and UMUC3 and absent in the more mesenchymal T24 and TCCSUP cells. Silencing IGFBP-2 using siRNA in epithelial RT4 cells promoted cell proliferation, invasion, colony formation, resulted in a reduction in epithelial (E-cadherin) and an increase in mesenchymal (N-cadherin) markers and increased sensitivity to cisplatin-induced cell death. Conversely, we observed the opposite effects when adding exogenous IGFBP-2 to the mesenchymal T24 cells. We determined that IGFBP-2 was epigenetically silenced via DNA methylation as the cells adopted a mesenchymal phenotype. Collectively these data suggest that IGFBP-2 acts as a tumour suppressor and marker of chemosensitivity in epithelial bladder cancer cells and that IGFBP-2 is epigenetically silenced by methylation to promote bladder cancer progression.
ISG15 induction is required during L1-mediated colon cancer progression and metastasis

Hyperactivation of Wnt/β-catenin target gene expression is a hallmark of colorectal cancer (CRC) development. We identified L1-CAM (L1) and Nr-CAM, members of the immunoglobulin family of nerve cell adhesion receptors, as target genes of the Wnt/β-catenin pathway in CRC cells. L1 overexpression in CRC cells enhances their motile and tumorigenic capacity and promotes liver metastasis. L1 is often localized at the invasive edge of CRC tissue. Using gene arrays and proteomic analyses we identified downstream signaling pathways and targets of L1-mediated signaling. Here, we found that the expression of interferon-stimulated gene 15 (ISG15) that operates much like ubiquitin (is conjugated to proteins by ISGylation), is elevated in the conditioned medium and in CRC cells overexpressing L1. Suppression of endogenous ISG15 levels in L1-expressing cells blocked the increased proliferative, motile, tumorigenic and liver metastatic capacities of CRC cells. ISG15 overexpression, on its own, could enhance these properties in CRC cells, but only to a much lower extent compared to L1. We show that NF-κB signaling is involved in the L1-mediated increase in ISG15, since blocking the NF-κB pathway abolished the induction of ISG15 by L1. Point mutations in the L1 ectodomain that interfere with its binding to L1 ligands, also inhibited the increase in ISG15. We detected high levels of ISG15 in human CRC tissue cells and in the adjacent stroma, but not in the normal mucosa. The results suggest that ISG15 is involved in L1-mediated CRC development and is a potential target for CRC therapy.
Prognostic value of immune cells in the tumor microenvironment of early-stage lung cancer: a meta-analysis

Background: Early-stage non-small cell lung cancer (NSCLC) patients carry significant risk of recurrence post-surgery. In-depth characterization of the immune tumor microenvironment (TME) can have prognostic value. This study aimed to evaluate the association of individual immune cell types in the TME with clinical outcomes in surgically resected, early-stage NSCLC. Methods: We performed a systematic literature search of the National Library of Medicine database through November 2019, investigating predefined biomarkers (CD3+ T cells, CD4+ T helper cells, CD8+ cytotoxic T cells, CD20+ B cells, CD56+ & CD57+ Natural Killer (NK) cells, CD68+ Tissue Associated Macrophages (TAMS), FoxP3+ T regulatory cells, and Mast Cells (MC)), and their association with survival following PRISMA guidelines. Results: Studies that adjusted for important clinical covariates (such as stage and age) showed that higher levels of CD8+ cytotoxic T cells were associated with improved OS (HR = 0.68; 95% CI, 0.50–0.93) and DFS (HR = 0.60; 95% CI, 0.41–0.87), while increased CD20+ B cells (HR = 0.16; 95% CI, 0.04–0.64) and CD 56/57+ NK cells (HR = 0.50; 95% CI, 0.26–0.95) were associated with improved OS; lung cancers with increased FoxP3+ T regulatory cells (HR = 2.22; 95% CI, 1.47–3.34) had worse OS. Conclusions: Immune cell components of the TME have prognostic value in early-stage, surgically resected NSCLC, and may reveal which patients are more likely to need additional systemic treatment, including immunotherapy. Clinical covariates need to be considered when evaluating the prognostic value of immune cells in the TME.