Miracle-dz/UniFAR-FTUs huggingface dataset:
Age estimation and comparison by dental and skeletal maturity in the age range of 9–18 years in the Mumbai region

Background: Age estimation is crucial in the identification of juveniles in conflicts with law, survivor of sexual assault, sportsperson, and civil cases. Aims: To estimate and compare the age (9–18 years) by dental and skeletal maturity in the Mumbai region. Settings and Design: This was a cross-sectional study. Materials and Methods: A total of 70 cases from 9 to 18 years of age were studied in 1 year in the urban population of the Mumbai region. Among 70 cases, 45 were males and 25 were females. Orthopantomogram and elbow joint radiographs were taken to assess the dental age through modified Demirjian's method and the radiological age through Sangma et al. staging method, respectively. Statistical Analysis: Data were analyzed using SPSS Statistics Version 26; descriptive statistics and regression statistics were used in the study. Results: Dental age by Demirjian's method in males with standard deviation was 15.25 (2.17), with a mean difference of 1.08 and significant P = 0.03. However, in females, dental age by Demirjian's method with standard deviation was 14.30 (1.94) with a mean difference of 0.74 and insignificant P = 0.07. Interclass correlation coefficient of dental age with chronological age, in males and females, showed 0.85 and 0.87 correlation, respectively. Correlation between the skeletal maturity and the dental age was reflected by the association of Demirjian stage 9 in the second molar with radiological stage 5 in males and stage 4 in females. Conclusions: It was concluded that Demirjian's method shows a significant correlation and P value for the age estimation in males of the Mumbai region.
Three-Dimensional Diagnosis in Orbital Reconstructive Surgery

Introduction: Orbital floor fractures are common among mid-face fractures. The general aim of treatment is to restore orbital volume and anatomy with grafts or reconstructive materials. Malpositioning of the implants and inadequate volume restorations are common complications of these procedures. The aim of our study is to present the surgical outcomes of orbital reconstruction aided by our algorithm of patient-specific virtual planning. Materials and Methods: The current study was performed on 77 patients with orbital wall fractures who were categorized into two groups: Group A – 42 patients (virtual planning) and Group B – 35 patients (traditional approach). Criteria of analysis included the presence of diplopia postoperatively and duration of surgical procedures. Results: Diplopia was recorded right after surgery in 16 cases (38.1%) of Group A and in 12 cases (34.3%) of Group B. However, 6 months postreconstruction, residual diplopia was recorded in 4 cases (9.5%) of Group A and in 12 cases (34.3%) of Group B. Mean operation time in Group A for the patients with isolated zygoma fracture was 2.23 h; for isolated orbital wall fracture was 1.98 h; and for combined zygoma, orbital wall, and facial bone fracture was 3.07 h. In Group B, these indexes were 3.47, 2.05, and 3.31 h, respectively. Conclusions: Application of virtual planning could significantly improve postoperative outcomes in orbital reconstruction. However, application of this technology could be limited by complicated defects of the orbital walls, which would require complex shape of the implant that might be difficult to be prevent virtually.
Secondary plasma cell leukaemia treated with single agent venetoclax

Marjilla Seddiq Manisha Gadgeel Yogindra Persaud Jennifer Lafferty S€ ureyya Savas an Division of Hematology/Oncology, Children’s Hospital of Michigan, Detroit, MI, Hematology/Oncology Flow Cytometry Laboratory, Children’s Hospital of Michigan, Detroit, MI and Pediatric Bone Marrow Transplant Program, Children’s Hospital of Michigan, Barbara Ann Karmanos Cancer Center, Wayne State University School of Medicine, Detroit, MI, USA. E-mail: ssavasan@med.wayne. edu
Effects of Input Modality on Vocal Effector Prioritization in Manual–Vocal Dual Tasks

Abstract. Doing two things at once (vs. one in isolation) usually yields performance costs. Such decrements are often distributed asymmetrically between the two actions involved, reflecting different processing priorities. A previous study (Huestegge & Koch, 2013) demonstrated that the particular effector systems associated with the two actions can determine the pattern of processing priorities: Vocal responses were prioritized over manual responses, as indicated by smaller performance costs (associated with dual-action demands) for the former. However, this previous study only involved auditory stimulation (for both actions). Given that previous research on input–output modality compatibility in dual tasks suggested that pairing auditory input with vocal output represents a particularly advantageous mapping, the question arises whether the observed vocal-over-manual prioritization was merely a consequence of auditory stimulation. To resolve this issue, we conducted a manual–vocal dual task study using either only auditory or only visual stimuli for both responses. We observed vocal-over-manual prioritization in both stimulus modality conditions. This suggests that input–output modality mappings can (to some extent) attenuate, but not abolish/reverse effector-based prioritization. Taken together, effector system pairings appear to have a more substantial impact on capacity allocation policies in dual-task control than input–output modality combinations.
Systematics and bionomics of the apoid obligate necrophages: the Trigona hypogea group (Hymenoptera: Apidae; Meliponinae)

A systematic revision and biological account is given of the only apoid obligate necrophages, the Trigona hypogea group, along with descriptions of Trigona necrophaga sp. nov. and the male of Trigona crassipes. Trigona necrophaga is endemic to eastern Panama and possibly the Choco; T. hypogea and T. crassipes are sympatric throughout the Amazon Basin and the Guianas. The lack of a corbicula on the hind leg and reduction of giant setae on the labial palpi, workers foraging upon carrion, lack of stored pollen in nests, and complete absence of pollen grains in larval provisions demonstrate obligate necrophagy in all three social, stingless bee species. Evolution of T. hypogea and T. crassipes from a common ancestor in the Amazon Basin is postulated, and T. necrophaga is likely to be an offshoot of T. crassipes. Morphology links T. crassipes and T. hypogea, but nest architecture joins necrophaga and crassipes. Facultative necrophagy in Trigona probably became obligate due to preadaptations including (1) massive forager recruitment via pheromone trails; (2) aggressive foraging on carrion exudates; (3) apical mandibular teeth; (4) rapid location of novel resources; (5) beneficial microbes in bee glandular secretions that metabolize protein and produce antibiotics, and (6) queen cells and food storage pots of the same size and close proximity. Accidental placement of regurgitated, partly-digested carrion in queen cells may have promoted admixture of hypopharyngeal glandular secretions and microbes with harvested liquid carrion. The most derived species, T. necrophaga, may have additional mutualist microbes because only this species has distinctive grey-green protein, and five Bacillus species in food pots and brood cells. No unusual anatomical features were found in worker bees. All three species make sweet, clear honey that contains some pollen but is of unknown origin.
Prevalence and Molecular Characterization of Extended Spectrum β-Lactamase, Plasmid-Mediated Quinolone Resistance, and Carbapenemase-Producing Gram-Negative Bacilli in Burkina Faso.

The spreading of carbapenemase-producing gram-negative bacilli (GNB) must be considered as an "urgent" threat. The aim of this study was to determine the prevalence of extended spectrum β-lactamase (ESBL), plasmid-mediated quinolone resistance (PMQR), and carbapenemase-producing GNB and to characterize the supporting genes in GNB specimens isolated from patients and healthy volunteers in Burkina Faso. From April to June 2016, carbapenemase-producing GNB screening was performed in 1,230 consecutive clinical specimens, and 158 fecal samples from inpatients and healthy volunteers without digestive pathology at Souro Sanou University Hospital, Bobo Dioulasso. Strains were identified by matrix-assisted laser desorption ionization-time of flight and antimicrobial susceptibility was tested with the disk diffusion method on Müller-Hinton agar. The presence of carbapenemase, ESBL, and PMQR genes was assessed by multiplex PCR. The molecular epidemiological study was performed using multilocus sequence typing analysis. From the 1,230 clinical samples, 443 GNB strains were isolated among which 4 (0.9%) were carbapenemase-producing isolates (Escherichia coli, n = 1; Acinetobacter baumannii, n = 3). Among the 158 fecal samples tested for carbapenemase-producing Enterobacteriaceae carriage, 13 (8.2%) were carbapenemase-producing isolates (E. coli, n = 4; Klebsiella pneumoniae, n = 6; A. baumannii, n = 2; Acinetobacter nosocomialis, n = 1; Acinetobacter bereziniae, n = 1). The strains from the two groups were resistant to broad-spectrum cephalosporins (100% for both), gentamicin (100% and 64.3%), levofloxacin (100% and 85.7%), and to amikacin (0% and 7.1%). The carbapenemase-encoding genes blaNDM-1, blaOxa-58, blaOxa-181, and blaVIM-2 were detected in clinical and in fecal samples. The majority (10/11) of the enterobacterial strains carried also blaCTX-M-15. The majority of the strains belonged to ST692 for E. coli, to ST147 for K. pneumoniae and to ST2 for A. baumannii. This study confirms the presence of carbapenemase-producing GNB in samples from patients and healthy volunteers. More effective active surveillance activities are needed.
Ten-year incidence and assessment of safe screening intervals for diabetic retinopathy: the OPHDIAT study

Background To estimate the 10-year incidence of referable diabetic retinopathy (DR) in a French population with type 1 and 2 diabetes mellitus (DM). A secondary objective was the assessment of safe screening intervals in patients with diabetes without retinopathy. Methods Observational, prospective and multicentric study between June 2004 and September 2017 based on a regional screening programme for DR in the Paris region. The incidence of referable DR in patients without retinopathy at baseline was calculated by the Turnbull survival estimator. A safe screening interval was defined as a 95% probability of remaining without referable DR. Results Among the 25 745 participants with type 1 (n=6086) or type 2 (n=19 659) DM, the 10-year cumulative incidence of referable DR was 19.10% (95% CI 17.21% to 21.14%) and 17.03% (15.78% to 18.35%), median (IQR) follow-up=3.33 (4.24) years. The safe screening interval for patients without DR at the first examination for type 1 and 2 DM was 2.2 (95% CI 2.0 to 2.4) and 3.0 (2.9 to 3.1) years, respectively. In a subgroup of low-risk patients with type 2 DM, the safe screening interval was 4.2 (3.8 to 4.6) years. Conclusions These data suggest that in Paris area, a 2-year, 3-year and 4-year screening interval was considered safe for type 1 DM, type 2 DM and for low-risk patients with type 2 DM, respectively, without DR at the first examination. While these data might be used to support the consideration of extending screening intervals, a randomised clinical trial would be suitable to confirm the safety for patients with DM.
Comparison of nocturnal blood pressure based on home versus ambulatory blood pressure measurement: The Ohasama Study

ABSTRACT Objectives The nocturnal blood pressure (BP) is a strong predictor of hypertensive target organ damage including that in cardiovascular diseases. The use of ambulatory BP (ABP) monitoring has enabled the evaluation of nocturnal BP and detection of non-dippers. This study compared nocturnal BP values, nocturnal decline in BP, and the prevalence of non-dippers based on ABP and home BP (HBP) measurements in a general population. Methods Data on HBP measured with HEM 747-IC-N (Omron Healthcare Co., Ltd.) and 24-hour ABP measured with ABPM-630 (Nippon Colin) were obtained from fifty-five participants aged ≥ 20 years (mean age: 65.1 years, 78.2% women). To exclude a systematic difference between the two methods, we conducted a validation study for HBP and ABP in another population that consisted of hypertensive outpatients (mean age: 65.4 years, 53.4% women). Results After adjusting for the systematic difference in BP between the two methods calculated in the validation study (3.9 mmHg for systolic and 3.0 mmHg for diastolic), morning and daytime (average of morning and evening) HBP were significantly lower than morning (average of 2 h after waking) and daytime (average of being awake) ABP, respectively. No significant difference was found in nocturnal BP between HBP and ABP monitoring regardless of the quality of sleep during nocturnal HBP measurement. Agreement between HBP and ABP in the detection of non-dippers was low mainly due to the difference in daytime BP values. Conclusion: HBP monitoring may be a reliable alternative to ABP for the assessment of nocturnal BP.
Susceptibility of Finnish landrace, Romney, and Finn × Romney lambs to a sporidesmin challenge

Abstract Five Finnish Landrace (F) rams and 10 Romney (R) rams were mated with F and R ewes to generate F × F, F? × R? , and R × R lambs. These lambs were compared for their susceptibility to an oral challenge with sporidesmin, the toxin causing facial eczema. All lambs of 17.0 kg or above were dosed at 4 months of age with sporidesmin (0.15 mg/kg liveweight). Resistance or susceptibility was assessed by taking a blood sample 21 days after challenge, and measuring serum gamma‐glutamyltransferase (GGT), an enzyme whose concentration is elevated after the liver injury resulting from a toxic challenge. A total of 199 animals (38, 62, and 99 animals respectively per breed group) were challenged, and percentages of animals with GGT concentrations below a threshold value indicative of subclinical facial eczema (50 i.u./l for F × F, 60 i.u./l for F × R and R × R) were 89, 69, and 33 respectively (P < 0.001 overall). For pairs of breeds, F × F and F x R had higher percentages unaffected than R × R (both P < 0.001).
Three-dimensional structural interrelations between cells, extracellular matrix, and mineral in normally mineralizing avian leg tendon

Significance The basic mechanism by which vertebrate collagenous tissues are mineralized remains unclear, despite the importance of mineralization for skeletal formation and regeneration. The present study of normally mineralizing avian leg tendon, that presents structural, molecular biological, and biochemical features common to other collagenous vertebrate tissues, reveals previously unknown three-dimensional interrelationships between an extensive tendon lacuno-canalicular network, the extracellular matrix, and mineral deposits. These interrelationships suggest a mechanism where the lacuno-canalicular system facilitates the transport of mineral ions and possibly mineralization precursors. These ions and putative precursors are initially present in interfibrillar collagen spaces and subsequently translocated to neighboring collagen fibrils. Mineral particles then nucleate in association with collagen to form the well-known collagen–mineral composite material of the skeleton. The spatial-temporal relationship between cells, extracellular matrices, and mineral deposits is fundamental for an improved understanding of mineralization mechanisms in vertebrate tissues. By utilizing focused ion beam-scanning electron microscopy with serial surface imaging, normally mineralizing avian tendons have been studied with nanometer resolution in three dimensions with volumes exceeding tens of micrometers in range. These parameters are necessary to yield sufficiently fine ultrastructural details while providing a comprehensive overview of the interrelationships between the tissue structural constituents. Investigation reveals a complex lacuno-canalicular network in highly mineralized tendon regions, where ∼100 nm diameter canaliculi emanating from cell (tenocyte) lacunae surround extracellular collagen fibril bundles. Canaliculi are linked to smaller channels of ∼40 nm diameter, occupying spaces between fibrils. Close to the tendon mineralization front, calcium-rich deposits appear between the fibrils and, with time, mineral propagates along and within them. These close associations between tenocytes, tenocyte lacunae, canaliculi, small channels, collagen, and mineral suggest a concept for the mineralization process, where ions and/or mineral precursors may be transported through spaces between fibrils before they crystallize along the surface of and within the fibrils.
Biologically infallible? Men's views on male age-related fertility decline and sperm freezing.

Trends in people having children later in life and increasing evidence of male age-related fertility decline (ARFD) has led some to propose sperm freezing as a suitable response. However, little consideration has been given to how men might respond to such a proposal, and there has been a paucity of empirical data to inform such a consideration. This paper arises from in-depth, semi-structured interviews with men (n = 25) who do not have children but want or expect to have them in the future. Data on men's perceptions of male ARFD and sperm freezing are presented and discussed in accordance with theoretical and conceptual tools relating to reproductive masculinity, biomedicalisation, gendered risk perception and meanings of sperm and masculinity. It suggests that that men's overall lack of concern regarding male ARFD and resistance towards ideas of sperm freezing result not only from a lack of exposure to evidence regarding male ARFD but are also shaped by ideals of reproductive masculinity, and may indicate resistance towards the idea of reproductive control. It argues that these positions perpetuate a gender unequal politicisation of ARFD and perpetuate particular gendered subjectivities relating to culpability and responsibility for guarding against risks of ARFD.
Helicobacter pylori infection is associated with elevated galactose-deficient IgA1 in IgA nephropathy

Abstract Background Mucosal immunity plays an important role in the pathogenesis of IgA nephropathy (IgAN). This study aimed to investigate if infection of Helicobacter pylori (H. pylori), a common bacteria in the gastrointestinal tract, associated with IgAN. Methods This study included 261 patients with IgAN and 46 healthy controls. Clinical information and plasma samples were collected from patients and healthy controls. H. pylori infection was confirmed by western blot. Plasma IgA1 and galactose-deficient IgA1 (Gd-IgA1) levels were detected by specific enzyme-linked immunosorbent assay. Results Total H. pylori infection rates showed no statistical differences between IgAN patients and healthy controls, but the infection rates of type I H. pylori in IgAN patients were significantly higher than those in healthy controls (44.4 vs. 28.3%, p = 0.040). Compared with uninfected patients, the systolic blood pressure, 24-h proteinuria, and blood urea nitrogen levels were significantly higher in patients with H. pylori infection (126.0 ± 15.5 vs. 119.6 ± 14.5 mmHg, p = 0.010; 1.8 ± 2.7 vs. 1.2 ± 1.4 g/24h, p = 0.013; 7.9 ± 5.4 vs. 6.7 ± 3.9 μmol/L, p = 0.042), especially in patients with type I infection (126.5 ± 15.4 vs. 119.6 ± 14.5 mmHg, p = 0.002; 1.9 ± 2.9 vs. 1.2 ± 1.4 g/24 h, p = 0.033; 8.1 ± 5.6 vs. 6.7 ± 3.9 μmol/L, p = 0.041). Similarly, patients with IgAN and type I H. pylori infection showed higher plasma Gd-IgA1 levels than uninfected patients (5.5 ± 2.2 vs. 4.5 ± 2.2 μg/mL, p = 0.037). Conclusions Virulent type I H. pylori infection is more common in patients with IgAN. Patients with IgAN and type I H. pylori infection showed lower renal function and higher underglycosylation of plasma IgA1.
Testing microsatellite loci and preliminary genetic study for Eurasian otter in South Korea

We used a non-invasive technique with microsatellite primers to investigate genetic variation among Eurasian otters Lutra lutra in eastern South Korea. We collected twenty two otter spraints in January and six in August 2008. We used spraints from five dead otters from five different river systems for the present genetic analysis. We extracted DNA from 20 spraints from the January sample. Ten microsatellite primers (Lut435, Lut453, Lut457, Lut604, Lut615, Lut701, Lut715, Lut717, Lut733, and Lut832) for Eurasian otters were tested, and four loci were successfully amplified for further analyses. The results of genotyping the otter population with microsatellite loci lead to the identification of 9 individuals from the Ungokcheon Stream. The Ungokcheon population also showed a genetic structure represented by the Hardy-Weinberg equilibrium.
The weekend effect for stroke patients admitted to intensive care: A retrospective cohort analysis

Objectives To examine the effect of weekend admission on short and long-term morbidity and mortality, for patients admitted to intensive care after suffering a cerebrovascular accident (stroke). Design, setting, and participants A hospital-wide, retrospective cohort study of 3,729 adult stroke patients admitted to the Beth Israel Deaconess Medical Centre (BIDMC) intensive care unit (ICU) between 2001 and 2012, using the Medical Information Mart for Intensive Care III (MIMIC-III) database. Primary outcome measures Primary outcome measures were ICU length-of-stay and mortality, hospital length-of-stay and mortality, proportions of patients discharged home after admission, and 6-month mortality. Results Overall, 23% of BIDMC ICU stroke admissions occurred over the weekend. Those admitted over the weekend were likelier to have suffered haemorrhagic stroke than those admitted during the week (60.6% vs 47.9%). Those admitted on the weekend were younger, and likelier to be male and unmarried, with similar ethnic representation. The OASIS severity of illness (32.5 vs. 32) and lowest day-one GCS (12.6 vs. 12.9) were similar between groups. Unadjusted ICU-mortality was significantly higher for patients admitted over the weekend (OR 1.32, CI 1.08–1.61), but when adjusted for type of stroke, became non-significant (OR 1.17, CI 0.95–1.44). In-hospital mortality was significantly higher for patients admitted to ICU over the weekend in both unadjusted (OR 1.45, CI 1.22–1.73) and adjusted (OR 1.31, CI 1.09–1.58) analyses. There was no significant difference in ICU or hospital length of stay. While patients admitted on the weekend appeared less likely to be discharged back to home and more at risk of 6-month mortality compared to weekday admissions, results were non-significant. Conclusions The effect of weekend ICU-admission for stroke patients appears to be significant for in-hospital mortality. There were no significant differences in adjusted ICU-mortality, ICU or hospital length-of-stay, or longer-term morbidity and mortality measures.