Miracle-dz/UniFAR-FTUs huggingface dataset:
Constructing ‘good teaching’ through written lesson observation feedback

ABSTRACT This paper explores the ways in which ‘good teaching’ is constructed through mentors’ written lesson observation feedback during Initial Teacher Education (ITE). Written lesson observation feedback has received little research attention, yet represents a potentially powerful activity for teachers’ development. It is also an important aspect of direct university-school-beginning teacher collaboration which is common across diverse programmes and ITE partnerships internationally. Data were collected from written lesson observation feedback given to beginning teachers (n=127) on one ITE programme in England across oneyear to a total of 508 lessons, and analysed through a typology of competing conceptions of teaching defined by Winch et al.: craft, executive technician, and extended professional. These data suggest that teaching is predominantly constructed through mentors’ written feedback as a craft or technical activity. In response, we argue that there is scope to broaden the evidence considered, in particular by bringing observed insights about beginning teachers’ practice into dialogue with research evidence to construct a more expansive vision of teaching as a professional endeavour. This paper extends previous work on written lesson observation feedback through a larger scale empirical study, and by connecting the practice with broader attempts seeking to improve teachers’ engagement with research evidence.
Refining the measurement of involvement in applications of relational framing theory

ABSTRACT Relational framing theory (RFT) explains how individuals process relational messages during interaction through two content-laden dimensions—dominance-submission and affiliation-disaffiliation—and a content-free intensifier: involvement. RFT research has generally utilized measures of relevance more conducive to the content-laden variables than to the content-free variable. This study advanced a new involvement scale that operates as a measure of degree rather than relevance. Participants (N = 319) provided perceptions of involvement in a hypothetical conversation. Results were consistent with reliable and valid measurement and a unidimensional factor structure. Future research can adopt the degree-based involvement scale to assess the extent to which a communicator is engrossed in interaction.
Mentoring as a transformative experience

ABSTRACT Graduate student mentoring is a key component of successful university experiences, specifically, improved student retention, completion, and satisfaction. Tensions in application of existing mentoring frameworks create difficulties with university-wide approaches. We used a descriptive qualitative study design to explore graduate students’ perspectives about mentoring. We interviewed 54 Canadian participants in 12 focus groups, including masters’ (n= 19), unclassified (n= 1), and PhD (n= 34) students from multiple disciplines. Focus groups ranged in size from two to seven students. After transcribing interviews, we used inductive content analysis to develop themes. Students described mentoring as a transformative experience because mentors smoothed their paths. Receiving mentoring required students to advocate for themselves and access university structures that promoted mentoring. Transformative mentoring supported students’ aspirational goals. Mentoring strengthens institutional supervisory practices and graduate student retention and success but it requires systematic approaches.
Recruiting T cells in cancer immunotherapy

T cell dynamics reveal that immunotherapy responses may rely on peripheral T cells Immunotherapies that enhance the ability of the immune system to target cancer cells have proven effective in a variety of tumor types, yet clinical responses vary across patients and cancers. The most effective immunotherapies to date are immune checkpoint blocking antibodies, which target inhibitory surface receptors expressed by T cells, particularly programmed cell death 1 (PD-1). One of the few robust correlates of clinical response to PD-1 blockade is the presence of tumor-infiltrating T lymphocytes (TILs) prior to treatment, with immune-infiltrated tumors achieving better responses than “immunedesert” tumors (1). Therefore, it has been widely assumed that PD-1 blockade reinvigorates preexisting cells within the tumor microenvironment (TME). However, recent studies of T cell dynamics suggest that the T cell response to immune checkpoint blockade (ICB) may originate outside the tumor and rely on peripheral T cell recruitment. This has important implications for patient selection, predictive biomarkers, and design of combination treatment regimens.
Methicillin-Resistant Staphylococcus Aureus Colonization and Mortality Risk Among Community Adults Aged 40-85

Introduction: The objective of this study was to assess the 11-year mortality risk of methicillin-resistant Staphylococcus aureus (MRSA) colonization in community-dwelling adults aged 40 to 85 years. Methods: The study analyzed the National Health and Nutrition Examination Survey (NHANES) 2001 to 2004 linked to the National Death Index through December 31, 2015. Our cohort of community adults aged 40 to 85 years was 6085 participants (representing 118 718 486 adults). Mortality risk from MRSA colonization was examined with an 11-year follow-up. Results: The 11-year mortality rates were 35.9% (95% CI, 25.4%- 46.4%) for MRSA-colonized and 17.8% (95% CI, 16.4%- 19.2%) for non-colonized participants. After adjusting for potential confounders the hazard ratio for mortality among those colonized with MRSA was 1.75 (95% CI, 1.12-2.73). Discussion: MRSA colonization in middle-aged and older adults in the community is associated with a significantly increased mortality risk. Considering that this effect was in the community and not in hospitalized patients, this finding of increased mortality risk is especially troubling.
Veterans Are Agreeable to Discussions About Firearms Safety in Primary Care harvard.edu/means-matter/recommendations/clinicians/.AccessedMarch8,2018.

Background: Discussing safe storage of ﬁrearms, including access, during times of crisis with veterans in primary care settings may enhance suicide prevention efforts. However, veteran attitudes toward such discussions are not well understood. The goal of this study is to understand the perspectives of veterans on discussing ﬁrearms storage safety with staff during primary care visits. Methods: Individual semistructured interviews with veterans were conducted by telephone, qualita-tively coded, and analyzed for themes. The sample was composed of veterans (n = 27) who had positive depression or post-traumatic stress disorder screens and who received care from Veterans Health Administration primary care team members trained to discuss ﬁrearms storage safety with patients. Results: Citing the urgent need to prevent veteran suicide, most veterans felt discussing ﬁrearms safety was acceptable and needed, even if discussions felt uncomfortable or they had concerns. Veterans identiﬁed the need for providers to be transparent in their purposes for asking about ﬁrearms and to respect veterans’ unique relationships with ﬁrearms. Discussion: Conducting ﬁrearms safety discussions in a primary care setting with veterans who are at elevated risk for suicide is acceptable to veterans when a respectful, veteran-centered, and transparent approach is used. ( J Am Board Fam Med 2021;34:338–345.)
Treatment Differences in Primary and Specialty Settings in Veterans with Major Depression

Introduction: The Veterans Health Administration (VHA) supports the nation's largest primary care–mental health integration (PC-MHI) collaborative care model to increase treatment of mild to moderate common mental disorders in primary care (PC) and refer more severe-complex cases to specialty mental health (SMH) settings. It is unclear how this treatment assignment works in practice. Methods: Patients (n = 2610) who sought incident episode VHA treatment for depression completed a baseline self-report questionnaire about depression severity-complexity. Administrative data were used to determine settings and types of treatment during the next 30 days. Results: Thirty-four percent (34.2%) of depressed patients received treatment in PC settings, 65.8% in SMH settings. PC patients had less severe and fewer comorbid depressive episodes. Patients with lowest severity and/or complexity were most likely to receive PC antidepressant medication treatment; those with highest severity and/or complexity were most likely to receive combined treatment in SMH settings. Assignment of patients across settings and types of treatment was stronger than found in previous civilian studies but less pronounced than expected (cross-validated AUC = 0.50-0.68). Discussion: By expanding access to evidence-based treatments, VHA's PC-MHI increases consistency of treatment assignment. Reasons for assignment being less pronounced than expected and implications for treatment response will require continued study.
Pluralisms? Social philosophy, social science and public policy in employment relations and human resource management

Alan Fox's frames of reference has sparked over half a century of debate between employment relations/human resource management pluralists, radicals and unitarists. But the notion of industrial relations pluralism itself continues to be highly disputed. This commentary tracks the journey from classical pluralism to neo-pluralism, then addresses three articles that offer a variety of radical pluralist alternatives. A fourth paper discussed, suggests a quantitative approach to testing Fox's frames, but this article makes a case for retaining the qualitative, case study method. A fifth explores the revival of paternalism on the border between unitarism and pluralism. Overall, the article argues that classical pluralism, based on trade unions and collective bargaining, is now outdated, but that neo-pluralism is capable of carrying forward its pragmatic, institutional spirit to explore the empirical complexity of contemporary employment relationships around the world. Finally, the discussion of employment relations pluralisms needs to re-engage with the wider political pluralism debate about liberal democratic societies and market economies.
Seismic performance of seawater and sea sand concrete-filled ultra-high performance concrete tubes under low-cycle reversed lateral loading

Seawater and sea sand concrete (SWSSC) filled ultra-high performance concrete (UHPC) tube (SFUHPC tube) column is a cement-based tubular composite column, which combines the excellent compressive strength and toughness of UHPC and lateral confining action from fiber reinforced polymer (FRP) hoops. The novel composite system has the potential to be used in marine engineering. The aims of this paper focus on evaluating the seismic performance of SFUHPC tube columns for being designed in costal and marine engineering. A series of low-cycle reversed lateral loading tests were conducted on five relatively large-scale specimens. FRP hoop volumetric ratio, compressive strength of filling SWSSC, and the types of FRP bar were selected as test parameters in this investigation. The failure modes, hysteretic responses and effects of main parameters were studied and discussed. SFUHPC tube columns exhibited flexural failure mode without visible spalling of the UHPC cover. It is noteworthy that the limit plastic drift ratios of all SFUHPC tube columns exceed the specified limits (0.02) in accordance to the rare earthquake requirement in seismic design code. The current study reveals that the proposed composite columns have acceptable ductility and relatively reliable lateral resistant performance for being used in the marine engineering. From the point of view of seismic performance, filling high strength SWSSC in UHPC tube is acceptable for the proposed composite system.
Response of benthic invertebrate assemblages to seasonal and habitat condition in the Wewe River, Ashanti region (Ghana)

Abstract Aquatic macro-invertebrates play a vital role in the food chain of river ecosystem at several trophic guilds and consumer levels, and are used as biomonitoring tools for aquatic ecosystem health. However, hydrologic conditions of these ecosystems have been severely altered because of the increase in urban development and agricultural expansion. This study examined benthic invertebrate response to processes that structure their community in the Wewe River, segmented into intact, medium, and severe condition zones. We sampled in 100 stations in a period of 4 months in the wet (June–September, 2019) and 3 months in the dry (January–March, 2020) seasons. Geometric series, rarefaction, and Hill numbers models were used to quantify invertebrate assemblages, while ordination technique, canonical correspondence analysis, was used to evaluate the influence of predictive factors on their assemblages. A total of 2,075 individuals belonging to 20 family taxa were registered. There was no significant difference in benthic assemblages between the dry and wet seasons. Predictive factors accounted for 47.04 and 50.84% variances, respectively. Taxa distribution patterns differed significantly only in the severely disturbed zone during the wet season. Neptidae, Libellulidae, and Chironomidae were the most abundant taxa, indicating their broad range habitat preference and their ability to adapt to seasonal changes. Asellidae and Perlidae were the least detected, suggesting their sensitivity to elevated levels of some water quality parameters. The findings highlight the threats to the benthic community and overall functional state of the Wewe River, with the need to consider the proposed conservation interventions indicated in this study.
COVID-19 severity in relation to sociodemographics and vitamin D use

Abstract Most COVID-19 cases are treated as outpatients, while the majority of studies on COVID-19 focus on inpatients. Little is known about the self-reporting and self-rating of the disease’s symptoms, and the associations of prophylactic use of dietary supplements with COVID-19 severity have not been addressed. The aims of this study are to evaluate COVID-19 severity and to relate them to sociodemographic characteristics and prophylactic dietary supplements. An observational patient-based study conducted through an online questionnaire on recovered COVID-19 patients. The patients were assessed for several severity parameters, sociodemographic parameters, and prophylactic dietary supplement use. A total of 428 patients were evaluated. Age and presence of comorbidities had positive associations with the severity parameters. The severe infection group had the highest proportion of patients stressed about COVID-19 (P < 0.05). Cigarette, but not hookah, smoking was significantly associated with less severe symptoms. Vitamin D negatively predicted disease severity (P < 0.05). In conclusion, stress, age, and presence of comorbidities were the most important positive predictors of COVID-19 severity, while prophylactic vitamin D use and smoking were significant negative predictors. The use of protective measures and other prophylactic dietary supplements was not significantly associated with symptom severity.
Prognostic role of Krebs von den Lungen-6 (KL-6) measurement in idiopathic pulmonary fibrosis: a systematic review and meta-analysis

Abstract Objectives Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial disease with limited therapeutic options. The measurement of Krebs von den Lungen-6 (KL-6) glycoprotein has been proposed for evaluating the risk of IPF progression and predicting patient prognosis, but the robustness of available evidence is unclear. Methods We searched Medline and Embase databases for peer-reviewed literature from inception to April 2020. Original articles investigating KL-6 as prognostic marker for IPF were retrieved. Considered outcomes were the risk of developing acute exacerbation (AE) and patient survival. Meta-analysis of selected studies was conducted, and quantitative data were uniformed as odds ratio (OR) or hazard ratio (HR) estimates, with corresponding 95% confidence intervals (CI). Results Twenty-six studies were included in the systematic review and 14 were finally meta-analysed. For AE development, the pooled OR (seven studies) for KL-6 was 2.72 (CI 1.22–6.06; p=0.015). However, a high degree of heterogeneity (I2=85.6%) was found among selected studies. Using data from three studies reporting binary data, a pooled sensitivity of 72% (CI 60–82%) and a specificity of 60% (CI 52–68%) were found for KL-6 measurement in detecting insurgence of AE in IPF patients. Pooled HR (seven studies) for mortality prediction was 1.009 (CI 0.983–1.036; p=0.505). Conclusions Although our meta-analysis suggested that IPF patients with increased KL-6 concentrations had a significant increased risk of developing AE, the detection power of the evaluated biomarker is limited. Furthermore, no relationship between biomarker concentrations and mortality was found. Caution is also needed when extending obtained results to non-Asian populations.
TEAD4 is a novel independent predictor of prognosis in LGG patients with IDH mutation

Abstract TEA domain family members (TEADs) play important roles in tumor progression. Till now, the genomic status of TEADs in patients with glioma has not been well investigated. To confirm whether the genomic status of TEADs could affect the prognosis of patients with glioma, the copy number variation (CNV), mutation and expression data of glioma cohorts in The Cancer Genome Atlas, Gene Expression Omnibus and Chinese Glioma Genome Atlas were comprehensively analyzed. Results showed that TEAD CNV frequency in lower grade gliomas (LGGs) was higher than in glioblastoma multiforme (GBM). Multivariate cox regression analysis showed that TEAD4 CNV increase was significantly associated with overall survival (OS) and disease-free survival (DFS) in LGGs (OS p = 0.022, HR = 1.444, 95% CI: 1.054–1.978; DFS p = 0.005, HR = 1.485, 95% CI: 1.124–1.962), while not in GBM. Patients with TEAD4 CNV increase showed higher expression level of TEAD4 gene. In LGG patients with IDH mutation, those with higher TEAD4 expression levels had shorter OS and DFS. Integrating TEAD4 CNV increase, IDH mutations, TP53 mutation, ATRX mutation and 1p19q co-deletion would separate patients with LGG into four groups with significant differences in prognosis. These study results suggested that TEAD4 variations were independent predictive biomarkers for the prognosis in patients with LGG with IDH mutation.
The effect of spiritual care on quality of life of patients with amputation caused by diabetes type 2: a clinical trial

Abstract Objectives This study aimed to investigate effect of a spiritual care on quality of life of patients with amputation caused by diabetes type 2. Methods The current study was a clinical trial. Fifty four patients with amputation caused by diabetes type 2 referred to Al-Zahra hospital at Isfahan was allocated to two case and control groups. Spiritual care training including transcendental meditation (T.M) technique was established for case group. Participants in case group performed four weeks of meditation technique following participating in sessions of meditation technique training. Data gathering was done using a standard tool to assess quality of life in patients with diabetes (diabetes quality of life: DQOL). Data was analyzed using SPSS software. Results Mean score of quality of life in the four areas of quality of life was not significantly different among case and control groups at baseline, however, mean score of quality of life in case group (2.25 ± 0.56) was significantly better than control group (2.52 ± 0.38) after intervention (p<0.001). Conclusions Given findings of the study, it seems that spiritual care can improve quality of life of patients with amputation caused by diabetes type 2.
History of preoperative therapy for pancreatic cancer and the MD Anderson experience

Systemic chemotherapy improves the survival of patients who undergo pancreatectomy, but whether chemotherapy should be delivered before or after surgery remains debated. At The University of Texas MD Anderson Cancer Center, localized pancreatic ductal adenocarcinoma (PDAC) has been preferentially treated with preoperative therapy—a practice supported by a robust history of institutional and national trials. In the following review, we discuss the historical use of perioperative therapy, our experience with it at MD Anderson Cancer Center and internationally, and the future of treatment and trials for PDAC.
Trends in the utilization of neoadjuvant therapy for pancreatic ductal adenocarcinoma

For patients with localized pancreatic cancer, neoadjuvant therapy (NT) is increasingly delivered before surgery to maximize the receipt of multimodality therapy and the odds of a margin‐negative resection. Three decades of refining the use of NT have led to its acceptance as a valid treatment approach for pancreatic adenocarcinoma. In this review, we discuss the rationale for and recent global trends in the utilization of NT for patients with pancreatic cancer.
Controversies in radiotherapy for pancreas cancer

The management of pancreatic adenocarcinoma remains an area of controversy and ongoing discovery. Despite advances in surgical and radiation techniques, as well as chemotherapeutic agents, outcomes of patients diagnosed with this devastating malignancy remain poor. This article aims to review the available literature evaluating the efficacy of adjuvant, neoadjuvant, and definitive radiation therapy. We will also highlight areas of ongoing research efforts being carried out to improve outcomes in this patient population.
Parties' Preferences for Office and Policy Goals

Although parties’ preferences for office and policy goals have been featured by many rational choice models of party behavior and a majority of coalition theories, the literature still lacks a measure and a comprehensive analysis of how parties’ preferences vary among parties and across countries. This study aims to fill this gap by presenting the results of an original expert survey protocol, which finds that parties pursue both goals simultaneously as office is sought both as and an end and as a means to affect policy, and that the degree to which they prefer policy versus office objectives varies across parties and countries. I provide an application of the preference ratings for policy versus office in the context of government formation, by using the ratings to solve for and predict the equilibrium coalition that should have formed in Spain after the 2015 elections. The government predicted by the model matches the government that formed, providing evidence of the ability of the preference ratings to generate reliable predictions of the composition of government coalitions.