Miracle-dz/UniFAR-FTUs huggingface dataset:
THE EFFECTS OF DISCLOSURE REGULATION

A firm actively manages its rival’s beliefs by disclosing and concealing information on the size of its process innovation. The firm’s disclosure strategy results from the trade-off between two effects on product market incentives. First, the firm’s competitor learns that the firm is efficient, which discourages the competitor. Second, the competitor becomes more efficient himself, since he can expropriate part of the disclosed knowledge, which encourages him. I characterize the equilibrium disclosure strategies for any knowledge spillover in a simple Cournot duopoly model, and illustrate the results graphically. Moreover, I compare the strategic disclosure equilibria with equilibria under non-strategic disclosure. JEL Code: D82, L23, O31.
A functional splicing variant associated with decreased asthma risk abolishes the ability of gasdermin B (GSMDB) to induce epithelial cell pyroptosis

Background—Genetic variants in the chromosomal region 17q21 are consistently associated with asthma. However, mechanistic studies have not yet linked any of the associated variants to a function that could influence asthma, and as a result, the identity of the asthma gene(s) remains elusive. Objectives—We sought to identify and characterize functional variants in the 17q21 locus. Methods—We used the Exome Aggregation Consortium (ExAC) browser to identify coding (amino acid-changing) variants in the 17q21 locus. We obtained asthma association measures for these variants in both the GERA cohort (16,274 cases and 38,269 matched controls) and the EVE Correspondence author: Quan Lu, PhD, Program in Molecular and Integrative Physiological Sciences, Harvard T.H. Chan School of Public Health, 665 Huntington Avenue, Boston, Massachusetts 02115, USA. Phone number: 617-432-7145, FAX: 617-432-3468; qlu@hsph.harvard. edu. +These authors contribute equally to this work HHS Public Access Author manuscript J Allergy Clin Immunol. Author manuscript; available in PMC 2018 November 09. Published in final edited form as: J Allergy Clin Immunol. 2018 November ; 142(5): 1469–1478.e2. doi:10.1016/j.jaci. 2017.11. 040. A uhor M anscript
PTT_A_328575 1..14

1Division of Musculoskeletal and Dermatological Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK; 2The Dermatology Centre, Salford Royal NHS Foundation Trust, Manchester NIHR Biomedical Research Centre, Manchester Academic Health Science Centre, Manchester, M6 8HD, UK Abstract: Biologics targeting Th1/Th17 cytokines have revolutionised psoriasis treatment. In addition to treatment effectiveness, it is important to define and understand the long-term risks of biologic therapy in order to guide therapy selection and minimise these risks for patients where possible. This review article summarises available evidence from trial data, observational studies and pharmacovigilance registries to explore key long-term risks of biologic treatment, and how these risks might be managed in clinical practice.
Genotype impact on body weight and linear body measurements of main and reciprocal crosses of Isa Brown and local chickens *Isaac, U. C. and Ezejesi, H. C. Department of Animal Science and Technology, Faculty of Agriculture,

The indigenous chickens of Nigeria are known for low productivity due to their unimproved genetic condition. However, the chickens are well adapted to hash environmental conditions and resistant to many endemic diseases. A lot of research works have been carried out with the aim of improving the local chickens, but little or no sustainable results are yet to be achieved. The present study seeks to improve growth traits of frizzle feathered, naked neck and normal feathered chickens through main and reciprocal crossbreeding with exotic Isa Brown chicken. Genotype impact on body weight (BWT), shank length (SL), drumstick length (DL), body girth (BG), body width (BW), keel length (KL), body length (BL) and wing length (WL) of 531 crossbred chickens was studied at 2, 10 and 20 weeks of age. The chickens were produced in 12 hatches at day-old. They comprised 123 Isa Brown x frizzle feathered, 49 Isa Brown x naked neck, 116 Isa Brown x normal feathered, 137 frizzle feathered x Isa Brown, 42 naked neck x Isa Brown and 64 normal feathered x Isa Brown genotypes. Data were subjected totwo-way analysis of variance. The NxIB, IBxN and IBxNa genotypes recorded higher significant (P<0.05) mean BWT at 2 (59.12±1.07 g), 10 (451.92±6.10 g) and 20(1133.66±12.00 g) weeks of age. Higher significant (P<0.05) meanSL (2.61 ±0.05cm), BW (10.06±0.12 cm), KL (3.44±0.06 cm), BL (11.26± 0.18cm) and WL (5.69 ±0.07cm) were obtained from IBxN while DL (4.74± 0.07cm) and BG (8.38± 0.08 cm) were obtained from NaxIB genotype at 2 weeks. At 10 weeks of age, higher significant (P<0.05) mean SL (5.24± 0.06 cm) and DL (10.44± 6.92 cm) from IBxNa; BG (16.74 ± 0.20 cm) and BW (20.59± 0.18 cm) from IBxN; KL (7.01± 0.07 cm) from NxIB; BL (26.78±1.42 cm) from FxIB and WL (13.72± 0.09 cm) from IBxF genotypes were recorded. The SL, DL, KL of IBxNa; BW of FxIB and BL of NaxIB genotypes had higher significant means at 20 weeks. The NxIB and IBxN genotypes which depicted outstanding growth performace at 2-10 weeks should be selected for improvement of fast growing chcikens while IBxNa, FxIB, NaxIB genotypes which recorded better performance at 20 weeks may be considered for development of egg-type chickens.
Sequence and structural conservation reveal fingerprint 1 residues in TRP channels . 2 3

Deny Cabezas-Bratesco, Francisco A. McGee, Charlotte K. Colenso, Kattina Zavala, 4 Danielle Granata, Vincenzo Carnevale, Juan C. Opazo, Sebastian E. Brauchi 5 6 Instituto de Fisiologia, Facultad de Medicina, Universidad Austral de Chile, Valdivia, 511-0566, 7 Chile. 8 Institute for Computational Molecular Science and Department of Biology, Temple University, 9 Philadelphia, USA. 10 School of Cellular and Molecular Medicine, University of Bristol, Bristol, BS8 1TD, UK. 11 Instituto de Ciencias Ambientales y Evolutivas, Facultad de Ciencias, Universidad Austral de 12 Chile, Valdivia, Chile. 13 Integrative Biology Group, Universidad Austral de Chile, Valdivia, Chile 14 Millennium Nucleus of Ion Channel-associated Diseases (MiNICAD), Valdivia, Chile. 15 Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, 20147, USA. 16 17 & D.C-B. and F.A.M. equally contributed to this work. 18 19 20
Proximate composition, haematology, carcass characteristics and meat yield of growing rabbits fed yam-cassava peel composite meal as a replacement for maize

Yam and cassava peels are by-product resulting from processing of yam and cassava for domestic cooking and other purposes which represent unutilized energy sources in many parts of the country because they have limited or no human food value. It's in view of the need for waste management and upsurge in prizes of conventional feeds (maize) with their increasing demand that necessitate, the need for waste peels from either yam or cassava which are largely discarded thereby constituting environmental nuisance to be used as ingredient (unconventional feedstuffs)in replacing maize(conventionalfeedstuff) as energy source for animal feeding.This study was therefore carried out to investigate the effect of replacing maizewith yam-cassava peel composite meal on haematology, carcass characteristics and meat yield of growing rabbits in 84-days feeding trial. Thirty-six weaner rabbits of mixed sex and strain and average initial weight of 500.89g were randomly allotted to six dietary treatmentsSix dietary treatment were formulated such that, Diet 1 (T1) contained maize and the proportion of maize in diet 1 (T1) was replaced with yam-cassava peel composite meal (YCPCM) in a ratio of 6:1 at 20, 40, 60, 80 and 100% in diet 2(T2), 3(T3), 4(T4), 5(T5) and 6(T6) respectively. Weighed amounts of feed were served every morning while fresh, cool and clean drinking water was provided ad-libitum and data were collected for proximate composition of yam cassava composite peel meal as well as the haematological profile of growing rabbits and carcass and meat yield. Proximate composition of YCPM revealed 89.60% dry matter (DM), 10.22% crude protein (CP), 14.29% crude fibre (CF), 1.27% ether extract (EE), 6.25% total ash (TA), 67.57% nitrogen free extract (NFE) and 2920.24kcal/kg metabolizable energy (ME Results on carcass characteristics and meat yield of growing rabbits indicated no significant (P>0.05) difference on all the parameters measured. Significant (P<0.05) difference occurred in some haematological (PCV, RBC, Hb, MCV and MCH) within the normal range of recommendation for healthy rabbits to it external and internal environment. This suggests that, 100%inclusion of YCPCM in diets of growing rabbits has no adverse deleterious effect on haematology, carcass characteristics and meat yield of growing rabbits.
Structure-property relationships in glass polyamide, The effects of average fiber diameter and diameter distribution.

We present the results of an extensive study of the influence of average fibre diameter and the width of the diameter distribution on the performance of injection moulded glass-fibre reinforced polyamide 66. In the average fibre diameter range from 9-18 μ m dry-as-moulded (DaM) composite unnotched impact and tensile strength decreased significantly. The composite notched impact performance and tensile modulus showed little dependence on fibre diameter. The influence of broadening the fibre diameter distribution by blending glass fibre samples of different average diameter was found to be particularly negative on the level of composite unnotched impact when compared at equal number average diameter. After hydrolysis treatment the composite tensile strength and modulus exhibited a large drop compared to the DaM results. In contrast, the unnotched impact results became insensitive to fibre diameter after hydrolysis. The average level of unnotched impact after hydrolysis was sufficiently high to show an increase over DaM when the fibre diameter was above 14 μ m. Residual fibre length correlated significantly with fibre diameter with a lower average length for thinner fibres. The interfacial shear strength was found to be in the range of 26-34 MPa for DaM composites. There was a highly significant inverse correlation between the DaM interfacial strength and the average fibre diameter. It is shown that results from both tensile and unnotched impact measurements can be brought back to single trend lines by using a Z average value for the average fibre diameter which is more heavily weighted to the thicker fibres in the distribution. further hypothesis notched impact performance. It is shown that results from both tensile and unnotched impact can back to single trend lines by using a Z average value for the average fibre diameter which more heavily weighted to the thicker fibres in the
The SEM Model of Better Workers’ Life in Companies

Abstract This paper seeks to build a model of the aging workers’ work-life quality and analyze the effect of its factors on the work engagement of elderly workers. Structural equation modeling was used to analyze the effects among seven constructs. The results show that the effect of the occupational stress of elderly workers on their work engagement and work satisfaction is negative, and the effects of the friendly working conditions, maintenance of work ability, and training programs on the work engagement of elderly workers are positive. The results show that the effect of health promotion in the workplace for elderly workers on their work satisfaction is positive, and so is the effect of work satisfaction on work engagement. The findings of this research can help employers better manage elderly workers and create a healthy and safe work environment for them. A better environment leads to higher work engagement of elderly workers.
Efectividad de programa de control de calidad en mamografía para el Sistema Nacional de Salud de Brasil

OBJETIVO: Evaluar la efectividad de un programa de control de calidad de imagen en los servicios de mamografia de la red del Sistema Unico de Salud. METODOS: Estudio prospectivo con analisis temporal de tipo "antes" y "despues" de una accion de vigilancia en salud. Participaron del estudio 35 servicios que tenian mamografos operativos y que realizaban examenes regularmente en el estado de Goias, Brasil, entre 2007 y 2009. Se evaluaron los servicios, por pruebas de desempeno de mamografos , procesadoras y demas materiales en tres visitas tecnicas, la calidad de la imagen y la dosis de entrada en el simulador radiografico de mama. Cada servicio recibio una puntuacion correspondiente al porcentaje de las pruebas en conformidad con los patrones. RESULTADOS: Los porcentajes promedio de conformidad de los servicios fueron de 64,1% (+/-13,3%) en la primera visita, 68,4% (+/-15,9%) en la segunda y 77,1% (+/-13,3%) en la tercera (p < 0,001). Las principales mejoras fueron decurrentes de los ajustes de la fuerza de compresion de la mama, del control automatico de exposicion y del alineamiento de la bandeja de compresion. Las dosis medidas estaban dentro del intervalo de conformidad en 80% de los servicios evaluados. CONCLUSIONES: La implantacion del programa en los servicios fue efectiva para la mejora de los parametros de operacion del mamografo, a pesar de que 40% de los servicios no hayan alcanzado el nivel aceptable de 70%. Este resultado indica la necesidad de darle continuidad a la vigilancia en salud.
Bayesian estimates of genetic parameters for bodyweights in Mecheri sheep of India

An understanding of genetic information and relationships among traits is required for an improvement programme to be successful. Therefore, this study aims to estimate certain (co)variance components for bodyweights Mecheri sheep collected at various ages. The data consisted of 2 768 records that were produced by the progeny of 110 sires and 748 dams maintained in the tropical climatic conditions of Tamil Nadu, India, between 2010 and 2020. Computations of the genetic parameters were made using Bayesian methods with Gibbs sampling. The direct heritability estimates for weight at birth (BWT), weaning (WWT), 6 months (6WT), 9 months (9WT) and one year old (12WT) were 0.155, 0.262, 0.069, 0.111 and 0.067, respectively. The maternal heritabilities obtained for the preand post-weaning traits were low, with the mean values for BWT, WWT, 6WT, 9WT and 12WT being 0.067, 0.030, 0.036, 0.040 and 0.039, respectively. The estimates of additive genetic correlations between bodyweights at the various ages were positive and of variable magnitude ranging from 0.198 (BWT–12WT) to 0.970 (6WT–9WT). The heritability of WWT was higher than the weights at other ages, and indicated the presence of significant genetic variation in this trait. There were also high correlations between WWT and post-weaning weights. Thus, WWT, recorded early in life, could be used as a selection criterion for improving the growth traits.
Treatment in Neuroendocrine Tumors: A Theoretic Model

131I-Metaiodobenzylguanidine (MIBG) and 90Y-DOTA-D-Phe1Tyr3-octreotide (DOTATOC) have been used as radiotherapeutic agents for treating neuroendocrine tumors. The tumor dose delivered by these agents is often insufficient to control or cure the disease. However, these 2 agents used together could potentially increase tumor dosewithout exceeding the critical organ dose because the dose-limiting tissues are different. In this paper, we investigate the conditions in which combined-agent therapy is advantageous and we quantify the expected tumor-dose gain.Methods: A series of equations was derived that predicted the optimal combination of agents and the fractional increase in tumor dose available from combined-agent therapy with respect to either 131I-MIBG or 90Y-DOTATOC. The results obtained from these derivations were compared with direct dose calculations using published dosimetric organ values for 131I-MIBG and 90Y-DOTATOC along with critical organ-dose limits. Tumor dose was calculated as a function of the tumor-dose ratio, defined as the 90Y-DOTATOC tumor dose per megabecquerel divided by the 131I-MIBG tumor dose per megabecquerel. Comparisons were made between the dose delivered to tumor with single-agent therapy and the dose delivered to tumor with combined-agent therapy as a function of the tumor-dose ratio and the fraction of activity contributed by each agent. Results: The dose model accurately predicted the optimal combination of agents, the range at which combined-agent therapy was advantageous, and the magnitude of the increase. For the published organ dosimetry and critical organ-dose limits, combined-agent therapy increased tumor dose when the tumor-dose ratio was greater than 0.67 and less than 5.93. The maximum combined-agent tumor-dose increase of 68% occurred for a tumor-dose ratio of 2.57, using 92%of themaximum tolerated 90Y-DOTATOC activity supplemented with 76% of the maximum tolerated activity of 131I-MIBG. Variations in organ dose per megabecquerel and dose-limiting values altered both the magnitude of the increase and the range at which combined-agent therapy was advantageous. Conclusion: Combining 131I-MIBG and 90Y-DOTATOC for radiotherapy of neuroendocrine tumors can significantly increase the delivered tumor dose over the dose obtained fromusing either agent alone. Prior knowledge of the normal-organ and tumor dosimetry of both agents is required to determine the magnitude of the increase.
Role of soil and larval excreta in the horizontal transmission of the baculovirus HpNPV and its implications in the management of teak defoliator Hyblaea puera

In baculovirus–insect systems, a mixed-mode transmission strategy involving vertical transmission of virus from parent to offspring, and horizontal transmission from infected to susceptible or from the environment is well known. In this study, we examined the role of soil and excreta as alternative routes of horizontal transmission of Hyblaea puera nucleopolyhedrovirus (HpNPV) in the teak defoliator H. puera and how larval crowding influences these processes. The laboratory experiment failed to identify horizontal transmission of the virus from the soil during pupation or eclosion. However, the role of soil as a reservoir cannot be ignored as chances of transport of viral particles from soil to tree bark are expected through termite nests built on teak stems, which needs further examination. On the other hand, the experiments proved excreta as a major route of horizontal transmission and the rate of infectivity during crowding of larvae was significantly higher. Further research on other routes of horizontal transmission and host behaviour influencing the same are discussed here in the context of their role in managing of teak defoliator outbreaks.
Patterns of brain degeneration in early-stage relapsing-remitting multiple sclerosis

Correspondence: Prof Adam Waldman Edinburgh Imaging Centre for Clinical Brain Sciences, University of Edinburgh Edinburgh BioQuarter: Chancellors Building Edinburgh EH16 4SB, United Kingdom E-mail: Adam.Waldman@ed.ac. uk Tel: 0131 242 6200 . CC-BY-NC-ND 4.0 International license It is made available under a is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. (which was not certified by peer review) The copyright holder for this preprint this version posted January 18, 2022. ; https://doi.org/10.1101/2021.11. 18.21266506 doi: medRxiv preprint
CORRIGENDUM: Radiative lifetimes of excited states of rubidium up to quantum number n = 12

The lifetimes of the Rb atomic levels n2S, n2P, n2D up to quantum number n=12 and of the 10, 11, 12 2F states were measured using pulsed dye laser excitation and a single-photon counting technique. Population by superradiance was applied for the excitation of the certain levels. Some data were determined by the measurement in Rb-rare-gas systems. The present results have been compared with the theoretical and experimental data given by different authors.
Online learning vs. Offline learning in an MIS course: Learning outcomes, readiness, and suggestions for the post-covid-19 world

This study aims to compare learning outcomes and technology readiness in online versus offline learning and to find suggestions from the viewpoint of learners. Besides, this study also compares differences in students’ perceptions among learning styles. The associations between several factors such as experience and gender, and learning preferences are also explored. A questionnaire was developed to gather data from students who enrolled in an MIS course during the middle of the COVID-19 pandemic. Around half of the students were assigned to study the topic ‘using MS Excel basics’ in offline sessions, whereas the rest were assigned to learn through recorded videos online. Responses from 44 students, together with their comments and suggestions, were used for data analysis. This study found that both online and offline delivery methods can improve students’ cognitive processes according to the Revised Bloom’s Taxonomy and their topic interest significantly. On-campus classes could significantly enhance students’ class attendance intention, but online classes could not. The cognitive process of RBT in terms of evaluating MS Excel content and class attendance intention of online students were significantly lower than offline students. Students also felt that place, equipment, and software on-campus were more ready than online environments. This work provides guidelines for both lecturers and universities in choosing teaching methods for using basic tools after the COVID-19 situation pass, selecting proper course types, designing course activities, and providing sufficient supports for better online learning outcomes. Research gaps suggested by past studies are filled up in this study. © 2021 International Consortium for Electronic Business. All rights reserved.
Effect of Leverage on Firm Value and How the Contextual Variables Affect This Relationship: A Case of Pakistan

The purpose of this study is to investigate capital structure in the Pakistani corporate sector in light of the interest rate gap with other countries and emerging Islamic banking in the country. The study investigates the effect of leverage on firm value (Tobin’s Q) and how other variables impact this relationship. The study used the System-GMM-Fixed effect model for linear analysis and fixed effect panel threshold regression model by Hansen (1999) for quadratic analysis using data from nonfinancial firms listed on the Pakistan Stock exchange for the period 2005 to 2019. The results show that there is a negative relation between leverage and the value of the firm. In contrast, debt and non-debt tax shields have a positive relationship with the value of the firm. The study also found that there is quadratic nature of leverage with the value of the firm. The study supports Trade-off theory, pecking order theory, while it doesn’t support agency theory.