Miracle-dz/UniFAR-FTUs huggingface dataset:
Association of Nutrition Education and Its Interaction with Lifestyle Factors on Kidney Function Parameters and Cardiovascular Risk Factors among Chronic Kidney Disease Patients in Taiwan

We evaluated the interactive effects of nutrition education (NE) and lifestyle factors on kidney function parameters and cardiovascular risk factors among chronic kidney disease (CKD) patients. This cross-sectional cohort study recruited 2176 CKD stages 3–5 patients aged > 20 years from Integrated Chronic Kidney Disease Care Network, Shuang Ho Hospital, Taiwan between December 2008 and April 2019. The multivariable regression analysis was performed to investigate the interactive effects of NE with lifestyle factors on kidney function parameters and cardiovascular risk factors. Relative excess risk due to interaction (RERI) and attributable proportion (AP) were applied to assess additive interaction. Patients who were smoking or physically inactive but received NE had better estimated glomerular filtration rate (eGFR) (β: 3.83, 95% CI: 1.17–6.49 or β: 3.67, 95% CI: 2.04–5.29) compared to those without NE. Patients with smoking and NE significantly reduced risks for having high glycated hemoglobin A1c (HbA1c) by 47%, high low-density lipoprotein cholesterol (LDL-C) by 38%, and high corrected calcium (C-Ca) by 50% compared to those without NE. Moreover, NE and smoking or inactive physical activity exhibited an excess risk of high C-Ca (RERI: 0.47, 95% CI: 0.09–0.85 for smoking or RERI: 0.46, 95% CI: 0.01–0.90 and AP: 0.51, 95% CI: 0.03–0.99 for physical activity). Our study suggests that CKD patients who were enrolled in the NE program had better kidney function. Thus, NE could be associated with slowing kidney function decline and improving cardiovascular risk factors.
Barriers and Facilitators of Safe Communication in Obstetrics: Results from Qualitative Interviews with Physicians, Midwives and Nurses

Patient safety is an important objective in health care. Preventable adverse events (pAEs) as the counterpart to patient safety are harmful incidents that fell behind health care standards and have led to temporary or permanent harm or death. As safe communication and mutual understanding are of crucial importance for providing a high quality of care under everyday conditions, we aimed to identify barriers and facilitators that impact safe communication in obstetrics from the subjective perspective of health care workers. A qualitative study with 20 semi-structured interviews at two university hospitals in Germany was conducted to explore everyday perceptions from a subjective perspective (subjective theories). Physicians, midwives, and nurses in a wide span of professional experience and positions were enrolled. We identified a structural area of conflict at the professional interface between midwives and physicians. Mandatory interprofessional meetings, acceptance of subjective mistakes, mutual understanding, and debriefings of conflict situations are reported to improve collaboration. Additionally, emergency trainings, trainings in precise communication, and handovers are proposed to reduce risks for pAEs. Furthermore, the participants reported time-constraints and understaffing as a huge burden that hinders safe communication. Concluding, safety culture and organizational management are closely entwined and strategies should address various levels of which communication trainings are promising.
Does parenting style moderate the relationship between parent-youth sexual risk communication and premarital sexual debut among in-school youth in Eswatini?

Background Based on propositions of the contextual model of parenting style, we examined whether there is a relationship between parent-youth sexual risk communication (PYSRC) and premarital sexual debut, and whether this relationship is moderated by the parenting style. Methods A cross-sectional study design was employed, and data were collected using a self-reported questionnaire from 462 youth (211 boys and 251 girls) aged 15–24 years in senior grades of three public high schools (two rural and one urban) in Eswatini (formerly Swaziland). A hierarchical binary regression analysis was conducted to examine the association between PYSRC and premarital sexual debut, and to test whether parenting style moderates this relationship. Results The mean age of participants was 18.9 (±1.85) years, and a slight majority were females (54.3%). About 35.9% of participants reported having had sex (i.e., premarital sexual debut). After adjusting for age, gender, living arrangement, school location, and peer sexual activity, neither PYSRC (adjusted odds ratio [AOR] = 1.01, 95% confidence interval [CI]: 1.00, 1.03) nor parenting style (AOR = 0.81, 95% CI: 0.64, 1.04) significantly predicted premarital sexual debut in the sample. Likewise, parenting style did not significantly moderate the relationship between PYSRC and premarital sexual debut (AOR = 1.01, 95% CI: 1.00, 1.02). Conclusion Contrary to propositions of the contextual model of parenting style, in this study, parenting style (authoritativeness) did not moderate the studied relationship, indicating the need for more studies to test the applicability of the contextual model of parenting style in African settings.
COVID-19 and Its Impact on Upper Gastrointestinal (GI) Cancer Management

Simple Summary In the midst of a pandemic resulting from the new virus, severe acute respiratory syndrome coronavirus 2, we carried out a review of the impact of the virus on patients suffering with upper gastrointestinal cancers. This previously unknown, but highly infectious virus, has rapidly spread throughout the world, causing devastation to people’s health on a global scale. The scientific and medical community have had to adapt and learn how to manage the virus, which has had knock on effects to patients suffering other diseases. Health services have been severely disrupted, so we reviewed the impact of this, specifically relating to the diagnosis and treatment of patients with upper gastrointestinal cancers. The situation is rapidly changing; therefore, we share the findings of our critical analysis of the available literature. Abstract Coronavirus disease 2019 (COVID-19), caused by the novel, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus, has left dramatic footprints on human health and economy. Cancer, whilst not an infective disease, is prevalent in epidemic proportions and cannot be pretermitted due to the impact of COVID-19. As we emanate from the second national lockdown in the UK with mixed feelings of hope and despair—due to vaccination and new COVID-19 variant, respectively—we reflect on the impact of the first wave on the provision on diagnosis and management of with upper gastrointestinal (UGI) cancers. This review provides a critical analysis of available literature on COVID-19 and its impact on cancer management in general and that of UGI cancers in particular.
Effect of Dietary Crude Protein Level on UT-B Expression and Nitrogen Efficiency in Growing Baluchi Male Lambs Fed Low or High Concentrate Diets

An experiment was carried out to evaluate how interactions between forage to concentrate ratio and dietary crude protein level may alter nitrogen efficiency and UT-B expression in growing Baluchi male lambs. Four Baluchi male lambs [30 ± 2 kg BW] were used in a 4 × 4 latin square design with 28-d periods and a 2 × 2 factorial arrangement of dietary treatments. The treatments fed forage: concentrate [FC; DM basis] ratios of 45:55 low concentrate (LC) or 25:75 high concentrate (HC) with dietary levels of CP of 14 low protein (LP) or 18% high protein (HP) [CP, DM basis]. Dry matter intake increased as dietary concentrate level increased. Treatments, dietary CP content and F: C ratio had significant effect on CP intake. Increasing dietary N content of the diet increased dry matter (DM), crude protein (CP) and organic matter (OM) digestibility. Forage to concentrate ratio had a significant effect on neutral detergent fiber(NDF) and OM digestibility. Treatments had significant effect on the CP, NDF and OM digestibility. There were an interaction between dietary CP content and F: C ratio on the ruminal pH, NH3-N concentration, individual volatile fatty acids (VFA) concentration, acetate: propionate ratio and BUN concentration. Except ruminal pH, all ruminal fermentation and blood metabolitefactors were affected by both dietaryCP content and F: C ratio in trial.Treatments had significant influence on the NI (g/d) and urinary N excretion (g/d) (% of N intake). Also, both dietary CP content and F: C ratio had significant effect on NI. The lambs consume high crude protein treatments tended to have greater urinary N excretion (g/d) than those consume low crude protein treatments. The F: C ratio had a significant effect on urinary N excretion (g/d). Approximately 6.56 times more UT-B was expressed by the rumen ventral sac for lambs on the treatments contain 18% crude protein relative to those on the treatments contain 14% crude protein. In conclusion this study shows that changes in characteristic of the diet produce significant changes in UT-B urea transporter expression within the ovine rumen. Changing urea entry into the GIT via dietary regulation of UT-B could serve as important mechanism to maintenance of nitrogen balance and increase nitrogen efficiency in Baluchi growing lambs. Our findings suggest that the dietary regulation of urea transporters plays a major role in altering urea entry into the gastrointestinal tract.
An Al Ga N/GaN Undoped Channel Heterostructure Field Effect Transistor with of 107 GHz

An Al Ga N/GaN heterostructure field effect transistor (HFET) grown on semi-insulating SiC with an 0.2- m gate length is reported. A source-drain ohmic contact resistance of 0.15- -mm was achieved through the use of high Al content and high n-type doping (1E19 cm ) in the AlGaN donor layer and optimized metallization procedures. We obtained a maximum transconductance of 260 mS/mm, a saturated current density of 1.2 A/mm, and a maximum oscillation frequency in excess of 107 GHz in the devices. The results are one of the best achieved up to now, and they will open up the potential for the applications of AlGaN/GaN HFET's in high-power microwave radar, remote sensing, and communications.
Decreased Levels of Thioredoxin o1 Influences Stomatal Development and Aperture but Not Photosynthesis under Non-Stress and Saline Conditions

Salinity has a negative impact on plant growth, with photosynthesis being downregulated partially due to osmotic effect and enhanced cellular oxidation. Redox signaling contributes to the plant response playing thioredoxins (TRXs) a central role. In this work we explore the potential contribution of Arabidopsis TRXo1 to the photosynthetic response under salinity analyzing Arabidopsis wild-type (WT) and two Attrxo1 mutant lines in their growth under short photoperiod and higher light intensity than previous reported works. Stomatal development and apertures and the antioxidant, hormonal and metabolic acclimation are also analyzed. In control conditions mutant plants displayed less and larger developed stomata and higher pore size which could underlie their higher stomatal conductance, without being affected in other photosynthetic parameters. Under salinity, all genotypes displayed a general decrease in photosynthesis and the oxidative status in the Attrxo1 mutant lines was altered, with higher levels of H2O2 and NO but also higher ascorbate/glutathione (ASC/GSH) redox states than WT plants. Finally, sugar changes and increases in abscisic acid (ABA) and NO may be involved in the observed higher stomatal response of the TRXo1-altered plants. Therefore, the lack of AtTRXo1 affected stomata development and opening and the mutants modulate their antioxidant, metabolic and hormonal responses to optimize their adaptation to salinity.
Relationships between Mindfulness, Purpose in Life, Happiness, Anxiety, and Depression: Testing a Mediation Model in a Sample of Women

Mindfulness is connected to positive outcomes related to mental health and well-being. However, the psychological mechanisms that account for these relationships are largely unknown. A multiple-step multiple mediator structural equation modeling (SEM) model was tested with mindfulness as the independent variable; purpose in life and behavioral activation as serial mediators; and happiness, anxiety, and depression as outcome measures. Data were obtained from 1267 women. Higher mindfulness was associated with higher levels of happiness and lower anxiety and depression symptoms. The association of mindfulness with the outcome variables could be partially accounted for by purpose in life and behavioral activation. The SEM model explained large proportions of variance in happiness (50%), anxiety (34%), and depression (44%) symptoms. Mindfulness is associated with both a sense of purpose in life and engagement in activities, which are also connected with positive outcomes. Moreover, having purposes in life is linked to higher levels of behavioral activation.
Dynamics of dissolved organic nitrogen and carbon in a Central European Norway spruce ecosystem

Dissolved organic nitrogen and carbon (DOC) are significant in the C and N cycle in terrestrial ecosystems. Little is known about their dynamics in the field and the factors regulating their concentrations and fluxes. We followed the fluxes and concentrations of the two in a Norway spruce (Picea abies (L.) Karst. ) forest ecosystem in Germany from 1995 to 1997 by sampling at fortnightly intervals. Bulk precipitation, throughfall, forest floor percolates from different horizons and soil solutions from different depths were analysed for major ions, dissolved organic N and DOC. The largest fluxes and concentrations were observed in percolates of the Oi layer, which contain amino N and amino sugar N as the major components. The average ratio of dissolved organic C to N in forest floor percolates corresponded to the C/N ratio of the solid phase. Concentrations and fluxes were highly dynamic with time and decreased with depth. The largest fluxes in forest floor percolates occurred when the snow melted. The concentrations and fluxes of dissolved organic N were significantly correlated with DOC, but the correlation was weak, indicating different mechanisms of release and consumption. The dynamics of dissolved organic N and DOC in forest floor percolates were not explained by pH and ionic strength of the soil solution nor by the water flux, despite large variations in these. Furthermore, the release of these fractions from the forest floor was not related to the quality and amount of throughfall. Concentrations of dissolved organic N in forest floor percolates increased with soil temperature, while temperature effects on DOC were less pronounced, but their fluxes from the forest floor were not correlated with temperature. In the growing season concentrations of both dissolved organic N and C in forest floor percolates decreased with increasing intensity of throughfall. Thus, the average throughfall intensity was more important than the amount of percolate in regulating their concentrations in forest floor percolates. Our data emphasize the role of dissolved organic N and DOC in the N and C cycle of forest ecosystems.
Experience and Health-Related Behavior in Times of the Corona Crisis in Germany: An Exploratory Psychological Survey Considering the Identification of Compliance-Enhancing Strategies

Despite the need for enduring preventive behavior in times of the COVID-19 pandemic, several counteracting behavioral reactions can be observed worldwide. Considering the grave consequences resulting from such health-related risk behavior, we carried out an online questionnaire study to identify personal characteristics that frame a motivational sketch of those who refuse to follow the pandemic-related preventive measures. Our results from a sample of N = 570 German participants already indicate obvious changes in relevant variables in the four-week investigation period during the pandemic’s initial phase (25 March to 22 April 2020). Above all, the willingness to take preventive measures decreased, as did the assessment of the pandemic’s severity. The perceived own vulnerability also turned out to be clearly age-dependent and, overall, our sample showed a negative affectivity deviating distinctively from a reference sample. These and other findings allow for identification of sources for public health interventions that can help to increase compliance with required prevention behavior, and thus, counteract COVID-19.
Aldose Reductase and the Polyol Pathway in Schwann Cells: Old and New Problems

Aldose reductase (AR) is a member of the reduced nicotinamide adenosine dinucleotide phosphate (NADPH)-dependent aldo-keto reductase superfamily. It is also the rate-limiting enzyme of the polyol pathway, catalyzing the conversion of glucose to sorbitol, which is subsequently converted to fructose by sorbitol dehydrogenase. AR is highly expressed by Schwann cells in the peripheral nervous system (PNS). The excess glucose flux through AR of the polyol pathway under hyperglycemic conditions has been suggested to play a critical role in the development and progression of diabetic peripheral neuropathy (DPN). Despite the intensive basic and clinical studies over the past four decades, the significance of AR over-activation as the pathogenic mechanism of DPN remains to be elucidated. Moreover, the expected efficacy of some AR inhibitors in patients with DPN has been unsatisfactory, which prompted us to further investigate and review the understanding of the physiological and pathological roles of AR in the PNS. Particularly, the investigation of AR and the polyol pathway using immortalized Schwann cells established from normal and AR-deficient mice could shed light on the causal relationship between the metabolic abnormalities of Schwann cells and discordance of axon-Schwann cell interplay in DPN, and led to the development of better therapeutic strategies against DPN.
Zingiber officinale Roscoe Rhizomes Attenuate Oxaliplatin-Induced Neuropathic Pain in Mice

Oxaliplatin is a platinum derivative chemotherapeutic drug widely used against cancers, but even a single treatment can induce a severe allodynia that requires treatment interruption and dose diminution. The rhizome of Zingiber officinale roscoe (Z. officinale, ginger), has been widely used in traditional medicine to treat various diseases causing pain; however, its effect against oxaliplatin-induced neuropathic pain has never been assessed. In mice, a single oxaliplatin (6 mg/kg, i.p.) treatment induced significant cold and mechanical allodynia. Cold and mechanical allodynia were assessed by acetone drop and von Frey filament tests, respectively. Water extracts of Z. officinale (100, 300, and 500 mg/kg, p.o.) significantly attenuated both cold and mechanical allodynia induced by oxaliplatin. Intrathecal pre-treatment with the antagonist 5-HT1A (NAN-190, i.t., 1 μg), but not with the antagonist 5-HT2A (ketanserin, i.t., 1 μg), significantly blocked the analgesic effect of Z. officinale against both cold and mechanical allodynia. However, 5-HT3 antagonist (MDL-72222, i.t., 15 μg) administration only blocked the anti-allodynic effect of Z. officinale against cold allodynia. Real-time PCR analysis demonstrated that Z. officinale significantly increased the mRNA expression of the spinal 5-HT1A receptor that was downregulated after oxaliplatin injection. These results suggest that Z. officinale may be a viable treatment option for oxaliplatin-induced neuropathic pain.
The Impact of Ground Tire Rubber Oxidation with H2O2 and KMnO4 on the Structure and Performance of Flexible Polyurethane/Ground Tire Rubber Composite Foams

The use of waste tires is a very critical issue, considering their environmental and economic implications. One of the simplest and the least harmful methods is conversion of tires into ground tire rubber (GTR), which can be introduced into different polymer matrices as a filler. However, these applications often require proper modifications to provide compatibility with the polymer matrix. In this study, we examined the impact of GTR oxidation with hydrogen peroxide and potassium permanganate on the processing and properties of flexible polyurethane/GTR composite foams. Applied treatments caused oxidation and introduction of hydroxyl groups onto the surface of rubber particles, expressed by the broad range of their hydroxyl numbers. It resulted in noticeable differences in the processing of the polyurethane system and affected the structure of flexible composite foams. Treatment with H2O2 resulted in a 31% rise of apparent density, while the catalytic activity of potassium ions enhanced foaming of system decreased density by 25% and increased the open cell content. Better mechanical performance was noted for H2O2 modifications (even by 100% higher normalized compressive strength), because of the voids in cell walls and incompletely developed structure during polymerization, accelerated by KMnO4 treatment. This paper shows that modification of ground tire rubber is a very promising approach, and when properly performed may be applied to engineer the structure and performance of polyurethane composite foams.
Mobile photographic screening for dental caries in children: Diagnostic performance compared to unaided visual dental examination.

OBJECTIVES This study was conducted to compare the use of intraoral photographs with the unaided visual dental examination as a means of dental caries detection in children. METHODS Children aged 4- to 14-year-olds were visually examined at their schools. Following dental examinations, children had five photographs of their teeth taken using a smartphone camera. Four dental reviewers, who are different from those who visually examined the children, assessed intraoral photographs for dental caries. Sensitivity, specificity, and inter-rater reliability agreement were estimated to assess the diagnostic performance of the photographic method relative to the benchmark visual dental assessments. Caries prevalence was measured using dft/DFT (decayed and filled teeth) index. RESULTS One hundred thirty-eight children (67 male and 71 female) were enrolled and had a mean age of 7.8 ± 2.1 years. The caries prevalence (dft/DFT > 0) using photographic dental assessments ranged from 30 percent to 39 percent but was not significantly different from the prevalence (42 percent) estimated with the visual dental examination (P ≥ 0.07). The sensitivity and specificity of the photographic method for detection of dental caries compared to visual dental assessments were 58-80 percent and 99.7-99.9 percent, respectively. The sensitivity for the photographic assessments was high in the primary dentition (63-82 percent) and children ≤7-year-olds (67-78 percent). The inter-rater reliability for the photographic assessment versus the benchmark ranged from substantial to almost perfect agreement (Kappa = 0.72-0.87). CONCLUSIONS The photographic approach to dental screening, used within the framework of its limitations, yielded an acceptable diagnostic level of caries detection, particularly in younger children with primary dentition.