Miracle-dz/UniFAR-FTUs huggingface dataset:
Irreversible transport in the stratosphere by internal waves of short vertical wavelength

The U-2 aircraft was instrumented and flown in the stratosphere during the Stratosphere-Troposphere Exchange Project's experiments of April 1984 to provide a set of simultaneous measurements by fast responding sensors that would aid in the identification of the modes of cross-jet transport. The measurements confirm the preexperimental deductions that transport is dominated by waves, not by large-scale circulations. Monotonic gradients of trace constituents normal to the jet axis, with upper stratospheric tracers increasing poleward and tropospheric tracers increasing equatorward, are augmented by large-scale confluence as the jet intensifies during cyclogenesis. These gradients are rotated, intensified, and significantly increased in area as their mixing ratio surfaces are folded by the differential transport of a very low frequency, transverse wave. The quasi-horizontal transport produces a laminar structure with stable layers rich in upper stratospheric tracers alternating vertically with less stable layers rich in tropospheric tracers. The transport proceeds toward irreversibility as higher frequency, shear-gravity waves extend the folding to smaller horizontal scales. It becomes irreversible when these short waves actually fold the isentropic surfaces and small-scale mixing develops. The progression to higher wave numbers is a discrete, not a continuous, cascade with major gaps in the observed horizontal wavelengths. The wave modes are identified by matching the observed amplitudes and phases against those obtained by linear perturbation theory. Prior to mixing, the wave-generated perturbations maintain the correlations produced by advecting the larger-scale mean gradients; thus the high resolution measurements support the linear turbulence closure assumption.
Geochemistry and geochronology of basic igneous rocks in Bairin Right banner, southeastern inner Mongolia, China: Implications for the final closure of the Paleo—Asian Ocean along the Xar Moron suture zone

This paper reports the first discovery of basic igneous rocks in Bairin Right Banner in southeastern Inner Mongolia, China. To understand the genesis and tectonic evolution of these rocks, we have carried out geochronology and geochemistry research on them. The results show that LA-ICP-MS zircon U-Pb concordant mean ages of massive basalt, diabase, and pillow basalt are 272.0 ± 2.8 Ma, 261.5 ± 3.2 Ma, and 256.5 ± 2.5 Ma, respectively, suggesting their formation during the Late Permian. The massive basalt, diabase, and pillow basalt are tholeiitic with low Mg# values in the ranges of 46.2–66.8, 54.4–71.0, and 53.5–58.2, respectively. They have similar chondrite-normalized rare earth element (REE) patterns. The intensity of REE differentiation is similar to that of typical enriched mid-ocean ridge basalts (E-MORB). The pillow basalts are relatively enriched in Ba and U, while slightly depleted in Rb and Th, and show geochemical affinity to E-MORB. The massive basalts and diabases have the same primitive mantle-normalized patterns and are relatively enriched in Rb, Ba, and U, while depleted in Nb and Ta, similar to the typical island arc magmas. Our new findings indicate that the intra-oceanic subduction of the Paleo-Asian Oceanic slab was still ongoing during the late Permian in the Bairin Right Banner area and, combined with previous studies, it might have been closed during the Late Permian to Early Triassic along the Xar Moron suture zone.
Supernumerary Marker Chromosome Identified in Asian Elephant (Elephas maximus)

Simple Summary Supernumerary marker chromosomes, as they are known in the human population, are usually small chromosomes that differ morphologically and structurally from the standard ones and in many cases are formed by genetically inert heterochromatin. Similar features were observed for a supernumerary chromosome discovered in two Asian elephants, a mother and her male offspring. In this study, we present its detailed analysis using several molecular cytogenetic techniques including laser microdissection and fluorescence in situ hybridization that allowed identification of this marker chromosome. Based on our findings, we propose the most possible mechanism for the origin of the marker studied. We extended our investigation and showed that the distribution of nucleolar organizer regions on the chromosomes of Asian and savanna elephants may be related to the distribution of heterochromatin. Supernumerary chromosomes or, in other words, additional or extra chromosomes added to typical human or animal karyotypes, have recently gained the attention of scientists as model systems for the study of chromosome evolution, which may include the chromosome marker described here. Abstract We identified a small, supernumerary marker chromosome (sSMC) in two phenotypically normal Asian elephants (Elephas maximus): a female (2n = 57,XX,+mar) and her male offspring (2n = 57,XY,+mar). sSMCs are defined as structurally abnormal chromosomes that cannot be identified by conventional banding analysis since they are usually small and often lack distinct banding patterns. Although current molecular techniques can reveal their origin, the mechanism of their formation is not yet fully understood. We determined the origin of the marker using a suite of conventional and molecular cytogenetic approaches that included (a) G- and C-banding, (b) AgNOR staining, (c) preparation of a DNA clone using laser microdissection of the marker chromosome, (d) FISH with commercially available human painting and telomeric probes, and (e) FISH with centromeric DNA derived from the centromeric regions of a marker-free Asian elephant. Moreover, we present new information on the location and number of NORs in Asian and savanna elephants. We show that the metacentric marker was composed of heterochromatin with NORs at the terminal ends, originating most likely from the heterochromatic region of chromosome 27. In this context, we discuss the possible mechanism of marker formation. We also discuss the similarities between sSMCs and B chromosomes and whether the marker chromosome presented here could evolve into a B chromosome in the future.
Mobile Banking and Commercial Bank Performance Nexus in Zimbabwe (2011-2021): Impact and Implications

The study investigated mobile banking and commercial banks’ performance nexus in Zimbabwe for the period 2011-2021. The investigation employed a pragmatic approach and a descriptive design. Primary data as well as secondary data were used to achieve the study objectives. Questionnaires, interviews and documentary guides were used to collect primary and secondary data respectively. There were 108 questionnaires distributed to staff members and customers of 6 sampled commercial banks in Zimbabwe having mobile banking experience. The interview guide was administered to bank managers to get a deeper understanding of the topic under research and as a mitigation strategy for addressing the flaws of the questionnaires. Analysis of quantitative data utilised descriptive analysis tools, correlations analysis tools as well as regression analysis tools whereas theme analysis was used for qualitative data. SPSS version 26 was used for this purpose. The study implications established that mobile banking and commercial banks’ performance nexus in Zimbabwe was significant and also enhanced mobile banking security capabilities and strengthened commercial banks’ performance. The investigation concluded that mobile banking’s success in enhancing commercial banks’ performance hinged on its ability to allow the user to get easier, cheaper and timely access to services. However, the study results showed that the cost of mobile banking services, government policies and intense competition inhibited the uptake of banking services. Commercial banks are recommended to continue strengthening the security of mobile banking services and to boost their uptake by bank customers in Zimbabwe.
Nanosecond switching of thin ferroelectric films

The switching time (ts) for polarization reversal in ferroelectric films of PbZr0.53Ti0. 47O3 and La‐substituted PbTiO3 has been investigated. The films were prepared by spin‐on and metalorganic decomposition followed by processing into ferroelectric capacitors having electrode areas ranging from 9 to 50 000 μm2. Pulse measurements show that under all our experimental conditions ts is instrumentally limited and that therefore the true switching time is smaller than the experimental resolution of 1.8 ns. This very fast polarization reversal can be explained by a nucleation‐rate‐controlled switching mechanism.
Long-Term Effect of Hyperbaric Oxygen Therapy on Gait and Functional Balance Skills in Cerebral Palsy Children—A Randomized Clinical Trial

This study aimed to explore the long-term effects of hyperbaric oxygen therapy on spatiotemporal gait parameters and functional balance in children with cerebral palsy. Thirty-nine children with hemiplegic cerebral palsy were randomly allocated to one of two groups: control or study. The children in both groups received traditional physical therapy three times per week for six months. In addition, the children in the study group received hyperbaric oxygen therapy five times/week for eight weeks. The GAITRite system and pediatric balance scale were used to assess spatiotemporal gait parameters and functional balance at baseline, post-intervention, and six months after the cessation of hyperbaric oxygen therapy. Post-intervention means of all measured parameters were significantly higher than pre-intervention means, but only for the study group (p < 0.05). However, both groups’ means at the six-month follow up were significantly greater than those at pre-intervention (p < 0.05). At the post-intervention and follow-up evaluations, comparisons between groups revealed a statistically significant difference in all measured parameters for the study group against the control group (p < 0.05). It can be concluded that adding hyperbaric oxygen therapy to physical therapy rehabilitation could be effective in improving spatiotemporal gait parameters and functional balance in children with cerebral palsy.
Comparison of Various Ultrasound-Based Malignant Risk Stratification Systems on an Occasion for Assessing Thyroid Nodules in Hashimoto’s Thyroiditis

Purpose To compare the diagnostic performance and unnecessary ultrasound-guided fine-needle aspiration (US-FNA) biopsy rate of the 2015 American Thyroid Association (ATA), 2016 Korean Society of Thyroid Radiology (KSThR), and 2017 American College of Radiology (ACR) guidelines for patients with and without Hashimoto’s thyroiditis (HT). Patients and Methods This retrospective study included 716 nodules from 696 consecutive patients, which were classified using the categories defined by the three guidelines: ATA, KSThR, and ACR. The malignancy risk in each category was calculated and the diagnostic performance and unnecessary fine-needle aspiration (FNA) rates of the three guidelines were compared. Results In total, 426 malignant and 290 benign nodules were identified. Patients with malignant nodules had lower total thyroxine levels and higher thyroid-stimulating hormone, thyroid peroxidase antibody, and thyroglobulin antibody levels than those without malignant nodules (all P<0.01). The margin difference was significant in non-HT patients (P<0.01), but comparable in HT patients (P=0.55). The calculated malignancy risks of high and intermediate suspicion nodules in the ATA and KSThR guidelines and moderately suspicious nodules in the ACR guidelines were significantly lower in non-HT patients compared with HT patients (P<0.05). The ACR guidelines showed the lowest sensitivity, highest specificity, and lowest unnecessary FNA rates in patients with and without HT. Compared to non-HT patients, HT patients had significantly lower unnecessary FNA rates (P<0.01). Conclusion HT was associated with a higher malignancy rate of thyroid nodules with intermediate suspicion according to the ATA, KSThR, and ACR guidelines. The three guidelines, especially ACR, were likely to be more effective and could allow a greater reduction in the percentage of benign nodules biopsied in patients with HT.
Kahane-Khinchine type inequalities for negative exponent

We prove a concentration inequality for δ-concave measures over ℝ n . Using this result, we study the moments of order q of a norm with respect to a δ-concave measure over ℝ n . We obtain a lower bound for q ∈ ]−1, 0] and an upper bound for q ∈ ]0,+ ∞[ in terms of the measure of the unit ball associated to the norm. This allows us to give Kahane-Khinchine type inequalities for negative exponent.
Circulating Interleukin-8 Dynamics Parallels Disease Course and Is Linked to Clinical Outcomes in Severe COVID-19

Severe COVID-19 frequently features a systemic deluge of cytokines. Circulating cytokines that can stratify risks are useful for more effective triage and management. Here, we ran a machine-learning algorithm on a dataset of 36 plasma cytokines in a cohort of severe COVID-19 to identify cytokine/s useful for describing the dynamic clinical state in multiple regression analysis. We performed RNA-sequencing of circulating blood cells collected at different time-points. From a Bayesian Information Criterion analysis, a combination of interleukin-8 (IL-8), Eotaxin, and Interferon-γ (IFNγ) was found to be significantly linked to blood oxygenation over seven days. Individually testing the cytokines in receiver operator characteristics analyses identified IL-8 as a strong stratifier for clinical outcomes. Circulating IL-8 dynamics paralleled disease course. We also revealed key transitions in immune transcriptome in patients stratified for circulating IL-8 at three time-points. The study identifies plasma IL-8 as a key pathogenic cytokine linking systemic hyper-inflammation to the clinical outcomes in COVID-19.
On the JLQ problem with uncertainty

Trofino Neto et al. (1992) have shown that one can formulate an LQ problem in the presence of uncertainties in such a way that the state and input weighting matrices can be derived as the solution of a nonlinear optimization problem. Here it is shown that for linear systems with jumping parameters, the introduction of uncertainties in the state and input matrices can still be carried out and a control law derived as the solution of a similar, but more complex, problem. Moreover, both of the nonlinear optimization problems can be formulated as linear matrix inequality (LMI) problems, i.e., convex optimization problems. Hence, if an optimal solution exists, it can easily be obtained by means of some available LMI software packages. The existence of such a solution is proved under a restrictive assumption.
On the stability of certain magnetic modes in fine ferromagnetic particles

Conditions of stability of the magnetization curling mode in fine spherical and cylindrical particles and of the magnetization helicoid structure in fine cylindrical particles are derived, and magnetization reversal processes in such particles are considered. The application of Ritz's method for solving the variational problem of finding the local magnetization vectors in the volume of a particle provides a convenient way of finding the conditions mentioned above. It has been shown that the magnetization curling mode in a spherical fine particle with radius larger than a critical one is stable in a well-determined interval of the external magnetic field, provided the magnetocrystalline anisotropy constant is less than a certain value K 0 . In such a case the hysteresis loop of a spherical particle measured in an easy direction is no longer rectangular. The magnetization curling and helicoid modes are both unstable in fine cylindrical particles with positive or zero values of the magnetocrystalline anisotropy constant. The hysteresis loop of such particles magnetized along the axis of rotation is rectangular.
DRC Plus: augmenting standard DRC with pattern matching on 2D geometries

Design rule constraints (DRC) are the industry workhorse for constraining design to ensure both physical and electrical manufacturability. However, as technology processes continue to shrink and aggressive resolution enhancement technologies (RET) and optical proximity correction (OPC) are applied, standard DRC sometimes fails to fully capture the concept of design manufacturability. Consequently, some DRC-clean layout designs are found to be difficult to manufacture. Attempts have been made to "patch up" standard DRC with additional rules to identify these specific problematic cases. However, due to the lack of specificity with DRC, these efforts often meet with mixed-success. Although it typically resolves the issue at hand, quite often, it is the enforcement of some DRC rule that causes other problematic geometries to be generated, as designers attempt to meet all the constraints given to them. In effect, designers meet the letter of the law, as defined by the DRC implementation code, without understanding the "spirit of the rule". This leads to more exceptional cases being added to the DRC manual, further increasing its complexity. DRC Plus adopts a different approach. It augments standard DRC by applying fast 2D pattern matching to design layout to identify problematic 2D configurations which are difficult to manufacture. The tool then returns specific feedback to designers on how to resolve these issues. This basic approach offers several advantages over other DFM techniques: It is enforceable, it offers a simple pass/no-pass criterion, it is simple to document as part of the design manual, it does not require compute intensive simulations, and it does not require highly-accurate lithographic models that may not be available during design. These advantages allow DRC Plus to be inserted early in the design flow, and enforced in conjunction with standard DRC.
The efficacy and adverse effects of anlotinib in the treatment of high-grade glioma: A retrospective analysis

Introduction Anlotinib, a novel multi-kinase inhibitor, was found to improve progression-free survival (PFS) in brain metastases. Methods This paper retrospectively analyzed 26 newly diagnosed or recurrent high-grade gliomas from 2017 to 2022, and the patients received oral anlotinib during concurrent postoperative chemoradiotherapy or after recurrence. Efficacy was evaluated according to the Response Assessment in Neuro-Oncology (RANO) criteria, and the main study endpoints were PFS at 6 months and overall survival (OS) at 1 year. Results After the follow-up, until May 2022, 13 patients survived and 13 patients died, with a median follow-up time of 25.6 months. The disease control rate (DCR) was 96.2% (25/26), and the overall response rate (ORR) rate was 73.1% (19/26). The median PFS after oral anlotinib was 8.9 months (0.8–15.1), and the PFS at 6 months was 72.5%. The median OS after oral anlotinib was 12 months (1.6–24.4), and the OS at 12 months was 42.6%. Anlotinib-related toxicities were observed in 11 patients, mostly grades 1–2. In the multivariate analysis, patients with Karnofsky Performance Scale (KPS) above 80 had a highermedian PFS of 9.9months (p = 0.02), and their sex, age, IDH mutation, MGMTmethylation, and whether anlotinib was combined with chemoradiotherapy or maintenance treatment had no effect on PFS. Conclusion We found that anlotinib combined with chemoradiotherapy in treating high-grade central nervous system (CNS) tumors can prolong PFS and OS and that it was safe.
Role of Nasal Fibroblasts in Airway Remodeling of Chronic Rhinosinusitis: The Modulating Functions Reexamined

Chronic rhinosinusitis (CRS) is a multifactorial inflammatory disease of the nose and sinuses that affects more than 10% of the adult population worldwide. Currently, CRS is classified into endotypes according to the inflammatory response (Th1, Th2, and Th17) or the distribution of immune cells in the mucosa (eosinophilic and non-eosinophilic). CRS induces mucosal tissue remodeling. Extracellular matrix (ECM) accumulation, fibrin deposition, edema, immune cell infiltration, and angiogenesis are observed in the stromal region. Conversely, epithelial-to-mesenchymal transition (EMT), goblet cell hyperplasia, and increased epithelial permeability, hyperplasia, and metaplasia are found in the epithelium. Fibroblasts synthesize collagen and ECM, which create a structural skeleton of tissue and play an important role in the wound-healing process. This review discusses recent knowledge regarding the modulation of tissue remodeling by nasal fibroblasts in CRS.
Colliding Stellar Winds: “Asymmetric” Thermal Conduction

We present the first results from modeling asymmetric thermal conduction in colliding stellar winds. This effect is important even when a weak magnetic field is present in windblown bubbles and planetary nebulae. Using a simplified model of this complicated physical situation, we demonstrate that asymmetric conduction may cause asymmetric structures even if the colliding winds were initially spherically symmetric. We also find that the interior of such hot bubbles becomes convective. The objects that this model represents will show higher asymmetry if observed in X-rays rather than in the optical.
On geostrophic motion of a non-homogeneous fluid

A general theoretical relationship between the (three-dimensional) vcLacity field and density field is established for geostrophic flow of a non-homogeneous fluid. The practical value of the relationship – which reduces to the celebrated two-dimensional theorem due to Proudman and Taylor when the fluid is homogeneous – is illustrated by means of three examples of flows in rapidly rotating fluids, namely (i) baroclinic waves in laboratory systems and in the atmosphere, (ii) the gyroscopic ‘steering’ processes in Jupiter's atmosphere that are implied by the ‘Taylor column’ theory of the Great Red Spot, and (iii) certain striking properties of ocean currents revealed by recent observations in the Atlantic and Mediterranean.
Lagrangian velocity covariance in helical turbulence

The effect of helicity on the Lagrangian velocity covariance UL(t) in isotropic, normally distributed turbulence is examined by computer simulation and by a renormalized perturbation expansion for UL(t). The first term of the latter represents Corrsin's (1959) conjecture (extrapolated to all t), which relates UL(t) to the Eulerian covariance and the distribution G(x, t) of fluid-element displacement. Truncation of the expansion at the first term yields the direct-interaction approximation for G(x, t). The expansion suggests that with or without helicity Corrsin's conjecture is valid as t → ∞ and that in either case UL(t) behaves asymptotically like $t^{-(r+\frac{3}{2})}$ if the spectrum of the Eulerian field varies like kr+2 at small wavenumbers. Corrsin's conjecture breaks down at small and moderate t if there is strong helicity while remaining accurate at all t in the mirror-symmetric case. Computer simulations for a frozen Eulerian field with spectrum confined to a thin spherical shell in k space indicate that strong helicity induces an increase in the Lagrangian correlation time by a factor of approximately three. Direct-interaction equations are constructed for the Lagrangian space-time covariance and the resulting prediction for UL(t) is compared with the simulations. The effect of helicity is well represented quantitatively by the direct-interaction equations for small and moderate t but not for large t. These frozen-field results imply good quantitative accuracy at all t in time-varying turbulence whose Eulerian correlation time is of the order of the eddy-circulation time. In turbulence with weak helicity, the directinteraction equations imply that the Lagrangian correlation of vorticity with initial velocity is more persistent than UL(t), by a substantial factor.