Miracle-dz/UniFAR-FTUs huggingface dataset:
Beta-cell Death and/or Stress Biomarkers in Diabetes Mellitus Type 1

Diabetes Mellitus type 1 (T1D) occurs due to disturbance intolerance of the immune system and invasion of β-cells by auto-reactive immune T cells and inducing deterioration of β-cells activity and viability and a prolong therapy with external insulin. This study was aimed to detect the predictive power as well as the degree of correlation of defined glutamic acid decarboxylase autoantibody (GADA), protein tyrosine phosphatase type A2 (IA-2A) and total antioxidant capacity (TAC) biomarkers on β-cells stress and/or death in T1D individuals as well as their first degree relatives (FDRs). Three groups of T1D patients, FDRs and apparently diseases free subjects had been enrolled in this work and evaluated for their serum GADA, IA-2A, C-peptide and TAC. The results revealed positive GADA and IA-2A in 88.6% and 40%, respectively, of T1D patients. The frequency of normal level and mean titer of C-peptide were significantly low among T1D and their FDRs, also the frequency of normal level and mean titer of TAC was significantly low among T1D patients. However, no significant difference in C-peptide level was noticed between the GADA+ and GADA- subjects with no significant effect of TAC level on the concentration of C-peptide. Finally, the concentration of C-peptide was significantly lower in IA-2-A positive than IA-2-A negative individuals. In conclusion, GADA, IA-2A and C-peptide combination can suggest the most powerful and cost-effective diagnostic approach in patients with T1D and their FDRs. In addition, IA-2A in T1D patient’s serum can be predicted for β-cell death and/or stress, however, GADA and TAC was found of no effect on the C-peptide level.
A study on loaded tooth contact analysis of a cycloid planetary gear reducer considering friction and bearing roller stiffness

The demand on gear drives of automation machinery increases recently, so as to reduce the labor cost and to improve the productivity. Precise motion and high power transmission are the essential requirements for development of such the gear drives. Among various types of gear drives, the reducers combined with involute and cycloid planetary gears play an important role to fulfill this requirement. This type of gear drives, i.e., so-called RV-drives (Fig. 1), has not only the advantage in high gear ratio, but also the good performances to share the transmitted load and to absorb the shock because of multiple tooth-pairs in contact. The conventional involute planetary gear, by contrast, can not fulfill the extreme requirements. Besides the geometrical design of the tooth profiles for the backlash and the transmission accuracy, the load analysis is the most important issue for successful application of such the drives. Two essential tasks must be handled for the analysis. First, the statically indeterminate contact problem of multiple tooth pairs should be solved. Second, the influences of the stiffness of components, the friction, the flank modification and the assembly/manufacturing errors on acting loads should be considered in the analysis model. Some calculation approaches for load analysis of the mentioned cycloid planetary gear drives can be fund in some but a little research papers. For example, Dong et al. (1996) proposed a calculation approach for calculating the acting forces in the cycloidal gear drive, where the bearing stiffness is assumed as the same. Blanche and Yang (1989, 1990) analyzed the influence of the manufacturing errors on the transmitted load and transmission errors. Hidaka et al. (1994) proposed an analytical method to analyze the influence of manufacturing errors. The analytical approach is later compared with FEM analysis by Ishida et al. (1996). Gorla et al. (2008) develop a simplified approach to analyze the
Weaning practices in phenylketonuria vary between health professionals in Europe

Background: In phenylketonuria (PKU), weaning is considered more challenging when compared to feeding healthy infants. The primary aim of weaning is to gradually replace natural protein from breast milk or standard infant formula with solids containing equivalent phenylalanine (Phe). In addition, a Phe-free second stage Lamino acid supplement is usually recommended from around 6 months to replace Phe-free infant formula. Our aim was to assess different weaning approaches used by health professionals across Europe. Methods: A cross sectional questionnaire (survey monkey®) composed of 31 multiple and single choice questions was sent to European colleagues caring for inherited metabolic disorders (IMD). Centres were grouped into geographical regions for analysis. Results: Weaning started at 17–26 weeks in 85% (n = 81/95) of centres, > 26 weeks in 12% (n = 11/95) and < 17 weeks in 3% (n = 3/95). Infant's showing an interest in solid foods, and their age, were important determinant factors influencing weaning commencement. 51% (n = 48/95) of centres introduced Phe containing foods at 17–26 weeks and 48% (n = 46/95) at > 26 weeks. First solids were mainly low Phe vegetables (59%, n = 56/95) and fruit (34%, n = 32/95). A Phe exchange system to allocate dietary Phe was used by 52% (n = 49/95) of centres predominantly from Northern and Southern Europe and 48% (n = 46/95) calculated most Phe containing food sources (all centres in Eastern Europe and the majority from Germany and Austria). Some centres used a combination of both methods. A second stage Phe-free L-amino acid supplement containing a higher protein equivalent was introduced by 41% (n = 39/95) of centres at infant age 26–36 weeks (mainly from Germany, Austria, Northern and Eastern Europe) and 37% (n = 35/95) at infant age > 1y mainly from Southern Europe. 53% (n = 50/95) of centres recommended a second stage Phe-free L-amino acid supplement in a spoonable or semi-solid form. Conclusions: Weaning strategies vary throughout European PKU centres. There is evidence to suggest that different infant weaning strategies may influence longer term adherence to the PKU diet or acceptance of Phe-free L-amino acid supplements; rendering prospective long-term studies important. It is essential to identify an effective weaning strategy that reduces caregiver burden but is associated with acceptable dietary adherence and optimal infant feeding development.
Growth and survival of Clarias batrachus (Lin.) larvae fed on formulated diets

An experiment was conducted for a period of 28 days using 7-day old C. batrachus larvae of initial total length (±S.D.) of 7.4 ± 0.49 mm and weight (±S.D.) of 2.8 ± 0.75 mg. Five test diets viz. diets I, II, Ill, IV and V were prepared. Diet I was formulated using 30% fish ineal (FM), 20% soybean meal (SM) and 20% Baker's yeast (BY), diet Ill using 15% FM, 20% SM, 15% cotton seed meal and 30% BY and diet IV using 20% FM, 30% BY and 30% powdered milk. The remaining two diets (diets II and V) were prepared using minced clam meat (96%) and BY (90%) respectively as the sole source of protein. Three replications were used for each treatment. The larvae fed on diet II exhibited significantly (P<0.05) better length gain and specific growth rate (SGR) than those of the larvae fed on diet Ill and there was no significant difference among the length gain and SGR of the larvae fed on diet I,II,IV and V. The larvae fed on diet II also showed significantly better weight gain and survival than those of the larvae fed on other diets. There was no significant difference between the condition factor of the larvae fed on diet II and IV. However, the larvae fed on diet II showed better condition factor than those of the larvae fed on other diets.
Haematopoiesis radioprotection in Balb/c mice by an aqueous mycelium extract from the Basidiomycete Pleurotus ostreatus mushroom

The study examined the radioprotective activity of an aqueous extract from Pleurotus ostreatus mycelium administered to Balb/c mice. Male mice were whole-body irradiated on day 0 ( 60 Co, at 0.43Gy/min) and divided into two groups. The extract was administered intraperitoneally to one group (100mg/kg) on days 2 10 to 2 6 and 2 2 to þ 1 with respect to the irradiation. The irradiated-control group was injected with saline solution; non-irradiated mice were used as negative controls. The radioprotective effect was evident by increases in bone marrow cellularity (5.1 £ 10 6 / femur vs. 1.1 £ 10 6 /femur in saline-control mice, p , 0.05), leucocyte counts (10.5 £ 10 9 /L vs. 4.5 £ 10 9 /L, p , 0.05), and spleen cellularity (11.2 £ 10 7 /spleen vs. 6.2 £ 10 7 /spleen, p , 0.05). The extract stimulated macrophage phagocytic activity as judged by a faster rate of carbon clearance in terms of absorbance ratios (1.62 vs. 2.01, p , 0.05). Therefore, this extract may be a candidate therapeutic agent with radioprotective activity for haematopoiesis damage, particularly to cells involved in immune function.
Consequences of valuing health: A macroeconomic perspective

In this paper we study the implications of valuing health in an otherwise standard real business cycle model. We contrast the model predictions over the business cycle with the corresponding data counterparts. We find that health can improve the predictions of the standard real business cycle model. In particular, the benchmark model with health improves the predictions in terms of the comovements between investment and market hours relative to output. Considering health in the environment also increases the volatility of consumption, investment and market hours while slightly reducing output volatility. In terms of health observables the benchmark model is able to account for practically all comovement between health outcomes and health expenditures as well as with output. Abstract In this paper we study the implications of valuing health in an otherwise standard real business cycle model. We contrast the model predictions over the business cycle with the corresponding data counterparts. We ﬁnd that health can improve the predictions of the standard real business cycle model. In particular, the benchmark model with health improves the predictions in terms of the comovements between investment and market hours relative to output. Considering health in the environment also increases the volatility of consumption, investment and market hours while slightly reducing output volatility. In terms of health observables the benchmark model is able to account for practically all comovement between health outcomes and health expenditures as well as with output.
Journal of Clinical and Experimental Ophthalmology Pattern of Ocular Diseases among Patients Attending a Geriatric Centre in Ibadan, Sub-Sahara Africa

reducing their burden. Consequently, all these will be leading to a rising trend in the prevalence of blindness in the decades to come, unless collaborative and conscientious efforts are made at challenging these diseases. Possible contributors to this include co-existing disabling systemic disorders, high costs of seeking healthcare and accompanying dwindling financial status due to retirement. False insight that visual loss is to be expected in later life and also some aged individuals from accessing medical care [11]. ABSTRACT Purpose: To assess the pattern of ocular diseases among patients attending a geriatric centre in Ibadan, Sub-Sahara Africa. Methods: This was a descriptive cross-sectional hospital based study conducted among patients aged 60 years and above. Four hundred and twenty-seven patients with visual acuity worse than 6/12 attending the clinic were selected and informed consent forms were signed by the respondents. An interviewer administered semi-structured questionnaire was used to obtain information on socio-demographic characteristics, as well as their ocular and medical history. Ocular examination and refraction was carried out on each respondent. Data was analysed using the IBM Statistical Package for Social Sciences (IBM SPSS) software version 20. Results: A total of 427 patients participated in the study. Mean age was 71.6+7.11 years. The commonest ocular abnormalities include cataract (91.6%), refractive error (90.2%) and glaucoma (61.6%). About one third of patients presented with mild visual impairment (37.9%) and blindness (37.7%) for distance vision, while more than three-quarter (88.5%) of respondents had near vision impairment. Conclusion: The prevalence of treatable ocular abnormalities was found to be high among the elderly, with cataract being the commonest. This upward trend of age related eye diseases compounded by existing gaps in eye-care services may continue, if urgent actions are not taken. Therefore, it is important for eye care providers and other stakeholders to provide eye health education and accessible eye care services for the elderly to eliminate these avoidable visual impairment and blindness.
Transactivation domain phosphorylation of wild-type p53 inversely correlates with clinicopathological features of HCC

Background & Aims: The p53 protein is a well-known tumor suppressor, and p53 gene mutation is related to poor prognosis in most types of tumors, including hepatocellular carcinoma (HCC). Although the expression of wild-type (WT) p53 protein is increased in 47.8% (43/90) of HCC cases, the WT p53 expression does not correlate with the expression of p53 target genes, such as p21 ( Cip1 ). Thus, we investigated the functional status of p53 in WT p53-carrying HCCs. Methods: We sequenced the p53 gene in 115 HCC samples and classified each sample as WT p53 or mutant (Mut) p53. We analyzed p53 expression, p53 transactivation domain (TAD) phosphorylation, p21 expression, Bax expression and catalase expression in each HCC sample by immunoblot analysis. We investigated the obtained data using Spearman correlation analysis. The functionality of the TAD phosphorylation sites was confirmed by a p53 immunoblot analysis in HepG2, Huh-7, and Hep3B cells. Results: The level of WT p53 protein was positively correlated with HCC grade but not with p21 protein expression ( p =0.103) or portal vein invasion ( p =0.288). Instead, p53 TAD phosphorylation in WT p53 HCCs was correlated with p21 protein expression ( p <0.001) and inversely correlated with both portal vein invasion ( p =0.001) and recurrence after surgical resection ( p =0.004). The importance of TAD phosphorylation for p53 activity was confirmed by p53 target gene expression. Conclusions: phosphorylation may also be an independent prognostic indicator in HCC patients carrying WT p53.
Do Alpha males deliver Alpha? Facial structure and hedge funds

Facial structure as encapsulated by facial width-to-height ratio (fWHR) maps onto masculine behaviors in males and may positively relate to testosterone. We find that high-fWHR hedge fund managers underperform low-fWHR hedge fund managers by 5.83% per year after adjusting for risk. Moreover, funds operated by high-fWHR managers exhibit higher operational risk, su↵er from a greater asset-liability mismatch, and are more likely to fail. We trace the underperformance to high-fWHR managers’ preference for lottery-like stocks and reluctance to sell loser stocks. The results are robust to adjustments for sample selection, marital status, sensation seeking, and manager race, and suggest that investors should eschew masculine managers. ⇤Lu is at the College of Business Administration, University of Central Florida. E-mail: yan.lu@ucf.edu. Teo (corresponding author) is at the Lee Kong Chian School of Business, Singapore Management University. Address: 50 Stamford Road, Singapore 178899. E-mail: melvynteo@smu.edu. sg. Tel: +65-6828-0735. Fax: +65-6828-0427. We have benefitted from conversations with Stephen Brown, Chris Cli↵ord (AFA discussant), Lauren Cohen, Fangjian Fu, Aurobindo Ghosh, Jianfeng Hu, Juha Joenväärä (FMA discussant), Matti Keloharju, Andy Kim, Weikai Li, Roger Loh, Roni Michaely, Sugata Ray, Rik Sen, Mandy Tham, Wing Wah Tham, Chishen Wei, and Yachang Zeng, as well as seminar participants at Singapore Management University, University of Central Florida, University of New South Wales, the 2018 Financial Management Association Meetings in San Diego, and the 2019 American Finance Association Meetings in Atlanta. Antonia Kirilova, Jinxing Li, and Aakash Patel provided excellent research assistance. Teo acknowledges support from the Singapore Ministry of Education (MOE) Academic Research Tier 2 grant with the MOE’s o cial grant number MOE 2014-T2-1-174. This is a revised version of the paper entitled “Do Alpha Males Deliver Alpha? Testosterone and Hedge Funds. ”
The Enriched Teaching Applications of Geometric Objects Subject with Concrete Models and its Effect on Student Achievements with Computer Assisted Instruction

– The aim of this study is to reveal the effect of using two different learning environments, namely a “learning environment enriched with concrete models and computer-aided learning environment” and “traditional and computer-aided learning environment” and their effects on students’ Geometric Object Subject achievement levels. For this purpose, a mixed research method was used in which qualitative and quantitative research methods were applied together. It was found that the achievement levels of the students were positively affected in both experimental groups, but the students' achievement in geometric objects was higher in the experimental group in which computer-assisted teaching environment and enriched teaching applications were used in combination.
Detection of Bacterial Speck Disease of Tomato ( Solanum lycopersicum L.) Through Biochemical Approaches and Evaluation of Its Biological Control Measure

— Bacterial speck is a prominent disease of tomato, caused by Pseudomonas syringae pv. tomato. The present investigation was carried out to isolate and characterize the bacterial disease as well as their biological control management by antibiotic and antimicrobial sensitivity assay. Creamy colored bacterial colonies were observed on yeast peptone glucose agar medium after streaking and incubation at 37°C for 16 hours. The isolated bacterium was identified as Pseudomonas syringae pv. tomato on the basis of morphological, physiological and biochemical tests method. The isolated bacterium was gram negative, rod shaped and motile. It showed positive result to catalase, MacConkey agar, potassium hydroxide, methyl red, Simmon citrate test and negative result to Kovac oxidase, and urease test. Triple sugar iron agar and Kligler iron agar tests showed positive result in isolated bacteria. Gentamycin revealed the highest inhibition zone with 24.5±0.2 mm against isolated bacterial strain. Terminalia arjuna plant extract showed highest 11.2±0.2 mm zone of inhibition against the isolated bacteria. The present investigation could be helpful for further molecular detection of the isolated bacteria and their biological control technique .
Integral representations for elliptic functions

We derive new integral representations for constituents of the classical theory of elliptic functions: the Eisenstein series, and Weierstrass’ ℘ and ζ functions. The derivations proceed from the Laplace– Mellin representation of multipoles, and an elementary lemma on the summation of 2D geometric series. In addition, we present results concerning the analytic continuation of the Eisenstein series to an entire function in the complex plane, and the value of the conditionally convergent series, denoted by (cid:1) E 2 below, as a function of summation over increasingly large rectangles with arbitrary ﬁxed aspect ratio. 1
The Green State of Ethiopia

Environmental sustainability has long been assumed to be a postmaterialist claim solely granted for affluent countries. This Western perception suggests that African and other developing countries are not capable of successfully dealing with environmental issues due to limited institutional and instrumental resources. Through semi-structured interviews with nine Ethiopian environment experts, and the supplementary method of field observations, this paper demonstrate empirical material from the green state of Ethiopia. Albeit being one of the poorest countries in the world, Ethiopia is displaying capacity to overcome environmental challenges and a willingness to undergo an environmentally sustainable transition process. Ultimately, environmental sustainability in Ethiopia is a possibility that contain challenges. The state have established environmental units, produced the comprehensive Climate Resilient Green Economy (CRGE) strategy and is actively transforming the rain-fed agriculture, investing in infrastructure and renewable energies, providing agricultural extension systems, rehabilitating degraded lands and creating environmental awareness. In addition, the national reforestation program, which includes restoration, creation and conservation of forests, boosts the forest industry and develops eco-system services, such as carbon sinks. However, weak implementation capacity disables the state from following through with ambitious environmental policies, and, in addition, the urge for economic development along an absence of strong regulative mechanisms stimulate the continuing conversion of forests and lands to agriculture.
CONTROL OF THE ROOT KNOT NEMATODE, Meloidogyne javanica INFECTED TOMATO PLANTS

The effects of one isolate of Bacillus subtilis and two isolates of B. thuringiensis subsp. aegypti ( Bt ), the bioproducts Agarin ® and Vertemic ® and the chemical nematicide Vydate L 24% on Meloidogyne javanica infection on tomato plants were tested in the greenhouse. Treatment with Vydate L 24% caused the great reduction (90-93.7%) in nematode infection and reproduction (numbers of nematode root galls, egg-masses/plant and number of 2 nd stage juveniles (J 2 ) /250 cc soil). Treatments with sporulated bacterial cells suspension of the tested Bacillus isolates resulted in 59.1-80.1% reduction in nematode infection whereas treatment with the cell free-filtrates gave low reduction (16-57.7%) in nematode infection and reproduction. In another test, treatments with Vydate L 24%, Agarin ® and Vertemic ® induced great reduction (66.3-91.8%) in nematode infection and reproduction on infected tomato plants. Also, treatments with Vydate L 24% and the tested bioproducts showed significant increase in the dry weight of the shoot and root systems in comparison with control treatment.
Effect of Paclobutrazol and Pinching on Cestrum Nocturnum Plants

A pot experiment was carried out to investigate the effect of paclobutrazol at the rate of 0, 400,500,600 ppm (as soil drench)and pinching once or twice on Cestrum nocturnum plants. The obtained results revealed that pinching the plants once decreased the fresh weight of branches, but increased N% in the branches and P% in the shoots. Pinching the plants twice decreased the branch length and the dry weight of branch; meanwhile it increased the stem and branch diameter, number of branches, fresh and dry weights of shoots, chlorophyll a and carotenoids content, P% in branches as well as K% in shoots. Paclobutrazol at 400 ppm caused an increase in the stem and branch diameter, number of branches/plant. The concentration of 500 ppm of paclobutrazol decreased the fresh and dry weights of the shoots, but it increased the number of branches/plant, chlorophyllaa,b and carotenoids content in the shoots as well as N and K %in the shoots. The combination between paclobutrazol at 500 ppm and pinching twice decreased the length of branches, but enhanced the stem and branch diameter, number of braches/plant, fresh and dry weights of shoots as well as the carotenoids content in the shoots. From the aforementioned results, it could be recommended the use of pinching the plants for two times alone or with the treatment of paclobutrazol at 500 ppm in order to produce a compact plant of high vegetative growth characters for using as a pot plants.