Miracle-dz/UniFAR-FTUs huggingface dataset:
Comparison of outcome prediction models post-stroke for a population-based registry with clinical variables collected at admission vs. discharge

Aim: The ability to predict outcomes can help clinicians to better triage and treat stroke patients. We aimed to build prediction models using clinical data at admission and discharge to assess predictors highly relevant to stroke outcomes. Methods: A total of 37,094 patients from the Taiwan Stroke Registry (TSR) were enrolled to ascertain clinical variables and predict their mRS outcomes at 90 days. The performances (i.e., the area under the curves (AUCs)) of these independent predictors identified by logistic regression (LR) based on clinical variables were compared. Results: Several outcome prediction models based on different patient subgroups were evaluated, and their AUCs based on all clinical variables at admission and discharge were 0.85–0.88 and 0.92–0.96, respectively. After feature selections, the input features decreased from 140 to 2–18 (including age of onset and NIHSS at admission) and from 262 to 2–8 (including NIHSS at discharge and mRS at discharge) at admission and discharge, respectively. With only a few selected key clinical features, our models can provide better performance than those previously reported in the literature. Conclusion: This study proposed high performance prognostics outcome prediction models derived from a population-based nationwide stroke registry even with reduced LR-selected clinical features. These key clinical features can help physicians to better focus on stroke patients to triage for best outcome in acute settings.
QUANTIFICAÇÃO DE VITAMINA C E A CAPACIDADE ANTIOXIDANTE DE VARIEDADES CÍTRICAS PRODUZIDAS NO

A citricultura e o ramo que mais se destaca na fruticultura mundial, o que faz dos citros as frutas mais produzidas no mundo. O Brasil e um dos maiores produtores de laranja. E importante tambem destacar a importância do Parana na producao de frutas citricas no pais, que vem crescendo progressivamente com o passar dos anos. Portanto, essa producao e altamente importante, pois as frutas citricas, principalmente laranjas e tangerinas, fazem parte da dieta dos brasileiros, por possuirem uma grande quantidade de vitaminas e fibras. A vitamina C apresenta propriedade antioxidante que e a primeira linha de anticorpos contra radicais derivados do oxigenio em meio aquoso. O objetivo geral deste trabalho foi avaliar a variacao do teor de vitamina C e a capacidade antioxidante em diversas variedades de laranjas e tangerinas produzidas no Estado do Parana, na regiao noroeste (Nova Esperanca) e centro ocidental (Campo Mourao). Para isso foram utilizadas algumas especies de laranjas e tangerinas, retirado o suco das mesmas e posteriormente analisados o grau de acidez, teor de solidos soluveis totais, teor de vitamina C e propriedades antioxidantes. As diferentes variedades de frutos citricos produzidas nas regioes noroeste e centro ocidental do estado do Parana apresentaram diferencas significativas quanto a quantidade de solidos soluveis totais, acidez titulavel e vitamina C. As variedades de laranjas pera e folha-murcha apresentaram quantidades de vitamina C maiores do que as variedades de tangerinas ponca e mexerica e do que a laranja-lima. A capacidade antioxidante foi maior na laranja folha-murcha.
Sustainable Grape Productivity and the Growth-Yield Relationship: A Review

Research reports and experimental efforts during the last century are presented with the goal to encourage discussion of balancing grapevine fruit yield and vine growth and leaf area. Fruit and subsequent processed quality are equally relevant economic issues as we strive to create conditions for both sustainable grapevine productivity and vine capacity for tolerating abiotic and biotic stress episodes. It is proposed that methods to achieve vine balance will vary with regard to macroclimate and cultivar, but will be most critical for those macroclimates commonly called cool-climate regions. Regardless, vine balance is most readily understood when based on the principles of vine carbon balance as mediated through well-understood factors such as cm2 leaf area/gram fresh weight of fruit at harvest and allmetric practices as the Ravaz Index and the Growth-Yield Relationship.
Computational Seismic Analysis of Dry-Stack Block Masonry Wall

In this research the computational modeling of Dry-Stack Block Masonry (DSM) walls subjected to cyclic monotonic loading testing is done. The analytical results were compared with experimental test results of the unreinforced and unconfined DSM cantilever walls subjected to lateral loading along with a constant axial load. ABAQUS has been used for Finite Element Modeling and analysis of the wall. Various material properties are defined for the wall in the software and modeled as a homogeneous material. The proposed numerical models had a good correlation with the experimental data. The test results discussion includes failure moods, load displacement curves, and stress/strain profile. Doi: 10.28991/cej-2021-03091668 Full Text: PDF
First-Wave COVID-19 Pandemic in Greece: The Role of Demographic, Social, and Geographical Factors in Life Satisfaction during Lockdown

The onset of the coronavirus pandemic led to profound changes in populations’ everyday lives. The main purpose of this research is to investigate the factors that affected life satisfaction during the first-wave lockdown in Greece. A web-based survey was developed, and 4305 questionnaires were completed corresponding to all Greek regional units. Statistical modeling (multivariate logistic regression) was performed to evaluate to which extent significant geographical attributes and socioeconomic characteristics are likely to influence life satisfaction during lockdown due to the pandemic. In the course of the present work, some key findings emerged: social distancing and confinement measures affected mostly women in relation to men; there was a strong positive association between life satisfaction and age, especially as regards the older population; changes to employment status, increase in psychosomatic disorders, and increased usage of social media were also likely to negatively impact people’s life satisfaction. By contrast, trust in the government and the media and limited health concerns seem to have a strong association with subjective wellbeing. Finally, life satisfaction does not depend much on geographical characteristics such as urbanity or insularity, highlighting that the lockdown had an impact on the Greek population regardless of the physical isolation.
Factors Affecting Mortality in Hematology Patients Accepted Intensive Care Unit

152 Erciyes Med J 2021; 43(2): 152–5 • DOI: 10.14744/etd.2020. 14477 ORIGINAL ARTICLE – OPEN ACCESS This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. Leyla Talan , Neriman Defne Altıntaş Factors Affecting Mortality in Hematology Patients Accepted to the Intensive Care Unit Objective: Patients with hematologic diseases can have increased life expectancy with newly developed chemotherapeutic agents, hematopoietic stem-cell transplantation, and further supportive therapy. However, intensive therapies lead to more life-threatening complications that require intensive care unit (ICU) admission. Therefore, understanding the factors affecting mortality is important when accepting these patients to the ICU. This study was conducted to explore the factors affecting the mortality of patients admitted to medical ICUs with a diagnosis of hematologic disease. Materials and Methods: The medical records of patients with diagnoses of hematologic diseases hospitalized in the medical ICU between March 2013 and March 2019 were retrospectively reviewed. Age, gender, subgroup of hematologic disease, APACHE II scores, admission diagnoses, mechanical ventilation requirement, renal replacement therapy, vasopressor therapy, and ICU and hospital outcomes were recorded. The factors affecting mortality were evaluated. Results: Patients with acute leukemia [29 (30%)], multiple myeloma [20 (21%)], lymphoma [22 (23%)], chronic leukemia [8 (9%)], and other hematologic diseases [15 (16%)] were identified and included during the 6-year study period. The median age of patients was 60 (27.5) years, and 50 (53%) patients were women. Bone marrow transplantation was performed in 20% of patients, and 75 (79%) patients required invasive mechanical ventilation. Vasopressor treatment was required in 49 (52%) of patients. The mortality rate was 55%. APACHE II scores were higher in nonsurvivors. Moreover, they required more mechanical ventilation, vasopressor treatment, and renal replacement therapy. According to regression analysis, high APACHE II scores, vasopressor therapy requirement, and presence of respiratory failure were the risk factors for mortality. Conclusion: High APACHE II scores, need for vasopressor therapy, and respiratory failure were identified as independent risk factors for mortality in patients with hematologic diseases admitted to the medical ICU.
Do pandemics lead to rebellion? Policy responses to COVID-19, inequality, and protests in the USA

This paper analyses how inequality across counties in the United States of America has shaped the impact of the COVID-19 pandemic on the incidence of protests. The empirical analysis combines weekly data between January and December 2020 on levels of COVID-19-related policy stringency and protest incidence at the county level with measures of county-level inequality at the start of the pandemic. The results show that more stringent measures to contain the pandemic were instrumental in driving the incidence of protests, but only in counties with high levels of inequality before the start of the pandemic, where grievances may have been initially stronger. Further analysis suggests that the impact of government responses to the COVID-19 pandemic is largely explained by changes in economic conditions (rise in unemployment and changes in economic activities and spending) in counties with the highest levels of inequality. Unequal counties with lower trust in political institutions but higher levels of social trust and civic engagement at the start of the pandemic are also more likely to experience more protests as a response to more stringent policies.
CAMA Centre for Applied Macroeconomic Analysis Financial Factors and the Business Cycle CAMA Working Paper 44 / 2020 May 2020

We study how financial factors shape and interact with the U.S. business cycle through a unified empirical approach where we jointly estimate financial and business cycles as well as identify their underlying drivers using a medium-scale Bayesian Vector Autoregression. First, we show, both in reduced form and when we identify a structural financial shock, that variation in financial factors had a larger role in driving the output gap post-2000 and a more modest role pre-2000. Our results suggest that the financial sector did play a role in overheating the business cycle pre-Great Recession. Second, while we document a positive unconditional correlation between the credit cycle and the output gap, the correlation of the lagged credit cycle and the contemporaneous output gap turns negative when we condition on a financial shock. The sign-switch suggests that the nature of the underlying shocks may be important for understanding the relationship between the business and financial cycles.
Synergistic extraction of U(VI) with mixtures of 2-ethyl hexyl phosphonic acid-mono-2-ethyl hexyl ester (PC-88A) and TBP, TOPO or Cyanex 923

The extraction of uranium (VI) from hydrochloric acid medium with PC-88A (H2A2 in dimeric form) and neutral organo phosphorous donors like TBP, TOPO and Cyanex 923 (S) in dodecane is reported. Experiments were performed with PC-88A, TOPO and Cyanex 923 alone and with the mixtures of PC-88A with TBP, TOPO or Cyanex 923. The presence of neutral donors in PC-88A solutions gave synergistic enhancement in the extraction of uranium (VI), the order being Cyanex 923>TOPO>TBP. The species extracted with PC-88A alone is UO2(HA2)2, whereas with TOPO or Cyanex 923 alone, it is UO2Cl2·2S and with the synergistic mixtures it is UO2(HA2)2·S. The power dependencies of S and PC-88A under experimental conditions have also been evaluated using non-linear regression analysis. The equilibrium constants of synergistic extraction have been calculated and the mechanism of the extraction is discussed. The effect of different organic diluents on uranium (VI) extraction with PC-88A has also been examined.
The paradox of change: Religion and fertility decline in South Korea

BACKGROUND The scholarship on the association of religion and fertility has paid relatively little attention to East Asia, a region that has experienced rapid fertility declines. South Korea is an important setting to study this association as its fertility decreased dramatically and its population includes sizable shares of Buddhists, Catholics, and Protestants, as well as a large nonreligious segment. OBJECTIVE We analyze patterns of religious differentials in fertility and their changes between the era of near-replacement fertility and that of lowest-low fertility by relating these changing patterns to massive and rapid socioeconomic and cultural shifts in South Korean society. METHODS Using the pooled data from the 1985, 2005, and 2015 census samples, which cover the period of falling fertility first to near replacement and then to far below replacement levels, we fit zero-inflated Poisson models to test for differences in the number of children ever born between women with a religious affiliation and those without one as well as across religious affiliations. RESULTS Controlling for age and education, Catholics and Protestants had fewer children than did women with no religious affiliation in the mid-1980s, which was the transitional phase of fertility change. But in the posttransitional stage, two and three decades later, Catholic and Protestant women had more children than did the nonaffiliated. In comparison, Buddhist women, who had a similar number of children to that of the nonaffiliated until the mid-2000s, had more children than the nonaffiliated in the mid-2010s. 1 Department of Sociology, College of Social Sciences, Hanyang University, Seoul, South Korea. Email: samyoo@hanyang.ac. kr. 2 University of California, Los Angeles, USA. Email: agadjanian@soc.ucla. edu. Yoo & Agadjanian: The paradox of change: Religion and fertility decline in South Korea 538 https://www.demographic-research.org CONTRIBUTIONS The findings shed light on the dynamic nature of the association between religious affiliation and reproduction in contexts of rapid and radical societal transformation by illustrating how evolving cultural meanings of religion may impact fertility outcomes.
Stationarity in annual daily maximum streamflow series in the upper Juruá River, western Amazon

R E S U M O O presente estudo tem o objetivo de investigar a hipótese de comportamento estacionário no regime de vazões do alto rio Juruá. Para tal, foram utilizadas as séries temporais de vazões diárias máximas anuais, gravados nas estações localizadas em Cruzeiro do Sul e Marechal Thaumaturgo, as quais foram analisadas por meio do teste de Mann-Kendall, de Pettitt e do Spearman Rho teste. Os resultados demonstram evidências suficientes para concluir que, em Cruzeiro do Sul, as vazões apresentam comportamento temporal ascendente, enquanto em Marechal Thaumaturgo descendente. Entretanto, tal inclinação não é significativa (p<0,05), permitindo concluir em favor da hipótese de estacionariedade nas séries de vazões da referida bacia hidrográfica. Assim, uma das implicações físicas associadas aos resultados obtidos pode ser a conclusão de que o regime de vazões na bacia do Alto Juruá não sofreu alterações significativas ao longo do tempo. Palavras-chave: estacionariedade, vazões máximas, Bacia do Alto Juruá.
Nereid’s orbit based on new precise observations

A new orbit of Triton was provided by our previous work, benefitted by new Gaia Data, both in a new precise reduction of charge-coupled device observations and in the planetary ephemeris INPOP19a. In this paper, we provide a new ephemeris for another main Neptunian satellite, Nereid. The orbit is fitted for the newest observations, including 2 075 ground-based observations during the period 1949-2018 and 83 space observations acquired by the Voyager 2 spacecraft in 1989. The dynamical model used here is consistent with that of our previous work. For the ground-based absolute observations of Nereid, the root-mean-square deviations are 0.201″ in right ascension and 0.189″ in declination. Finally, a comparison with the HORIZONS ephemeris is made and discussed.
Synthesis, Properties, and Structural Characterization of Bromo‐ and Iodotetracarboxylatodiruthenium(II,III) Compounds

The synthesis and characterization of the compounds [Ru2X(μ-O2CPh)4]n [X = Br (1), I (2)] and [Ru2X(μ-O2CC6H4-p-OMe)4(H2O)] [X = Br (3) and I (4)] is described. The structures of these compounds were determined by single-crystal X-ray diffraction. The molecular structures of [Ru2Br(μ-O2CCMePh2)4(EtOH)·0.5EtOH] (5·0.5EtOH) and [Ru2I(μ-O2CCMePh2)4(MeOH)·0.5H2O] (6·0.5H2O) are also reported. Complexes 1 and 2 show a zigzag polymeric arrangement with the diruthenium units linked by bromide and iodide ligands, respectively. The molecular nature of compounds 3 and 4 shows the influence of the axial ligand in the arrangement in the solid state, which contrasts with the polymeric structure found in all chlorodiruthenium(II,III) derivatives with arenecarboxylate bridging ligands. The Ru−Ru bond lengths for all complexes range from 2.2756(17) to 2.2906(7) and 2.273(3) to 2.2965(6) A for the bromide and iodide derivatives, respectively. This study demonstrates that the nature of the axial ligand plays an important role in the arrangement in the solid state and in the electronic properties of the halotetracarboxylatodiruthenium(II,III) complexes. Thus, the iodo derivatives show an intense solvatochromism, whereas the solvatochromism is slight in the bromo derivatives and is not observed in the chloro complexes. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)
The Effect of Servant Leadership on Lecturer Performance Through Trust in Leader as A Mediation Variable

This study aimed to analyze the significant influence of Servant Leadership, Trust In leader on Performance. This research was conducted with a quantitative method through a survey approach of respondents who were permanent lecturers at the Poli Padamara Halmahera Utara through the distribution of online questionnaires (Google form). The data collected was then analyzed using the SMART PLS software. The research findings show that there is an influence of servant leadership on performance and the influence of servant leadership on trust in leaders. The results also showed the influence of trust in leader on performance and the influence of servant leadership on performance through trust in leader as a mediating variable. For further research, it is expected that further analysis of second line leaders is needed so that the results of the analysis are more comprehensive and not solely on top leaders
The kynurenine derivative 3-HAA sensitizes hepatocellular carcinoma to sorafenib by upregulating phosphatases

Objectives: Sorafenib is the only FDA-approved first-line target drug for HCC patients. However, sorafenib merely confers 3-5 months of survival benefit with less than 30% of HCC patients sensitive to sorafenib therapy. Thus, it's necessary to develop a sensitizer for hepatocellular carcinoma (HCC) to sorafenib. Methods: The principal component analysis, gene ontology, and KEGG analysis are utilized following RNA-sequencing. The mass spectrometry analysis following immunoprecipitation is performed to discover the phosphatase targets. Most importantly, both the cell line-derived xenograft (CDX) and the patient-derived xenograft (PDX) mouse model are used to determine the effect of 3-HAA on sorafenib-resistant HCC in vivo. Results: In nude mice carrying HCC xenograft, tumor growth is inhibited by sorafenib or 3-HAA alone. When used in combination, the treatment particularly prevents the xenograft from growing. Combined treatment also suppresses the growth of sorafenib-resistant (≥30mg/kg) PDXs. In a set of mechanistic experiments, we find enhanced AKT activation and decreased apoptotic cells in de novo and acquired sorafenib-resistant HCC cells and tissues. 3-HAA decreases AKT phosphorylation and increases the apoptosis of HCC in both cultured cells and mouse xenografts by upregulation of phosphatases PPP1R15A/DUSP6. PPP1R15A/PPP1α directly reduces Akt phosphorylation while DUSP6 decreases Akt activity through inhibiting PDK1. The AKT activator abolishes 3-HAA inhibition of HCC growth in vitro and in mice. Conclusion: This study demonstrates that 3-HAA sensitizes HCC cells to sorafenib by upregulation of phosphatases, suggesting it as a promising molecule for HCC therapy.
Investigation of mechanical properties and thermal stability of the thinnest tungsten nanowire by density functional theory

The most stable structure of the thinnest tungsten (W) nanowire with the radius of 1.9 A was predicted by the simulated annealing basin-hopping method (SABH) with the tight-binding (TB) potential and the penalty algorithm. At this small scale, the predicted tungsten nanowire is helical instead of in the BCC arrangement found in bulk tungsten material. The density functional theory (DFT) calculation on the uniaxial tensile simulation was carried out to obtain the stress–strain profile of the thinnest tungsten nanowire. From the stress–strain curve, the Young's modulus is about 7.3% lower than that of bulk W, and the yielding stress is about 31 times higher than that of bulk W. The adsorption energy variations of an O2 molecule on the top site of W atom at strain of 0 and 0.043 were used to explore the axial strain effect on the electronic properties of the thinnest W nanowire within the elastic region. Because the d-band center of the thinnest W nanowire at the strain of 0.043 becomes slightly closer to the Fermi level than that at strain of 0, the W atom of strained W nanowire becomes more reactive, resulting in the higher adsorption energy and the shorter W–O bond length. The density functional theory molecular dynamics (DFT-MD) simulation for the temperature elevation process was carried out for understanding the thermal stability of the thinnest W nanowire. The result shows the considerable deformation of local structure occurs at the temperature higher than 860 K, indicating the thinnest W nanowire can be safely used at the temperature lower than 860 K.
Room temperature single electron effects in a Si nano-crystal memory

An MOS memory based on Si nano-crystals has been fabricated. We have developed a repeatable process of forming uniform, small-size and high-density Si nano-crystals and spherical nano-crystals of about 4.5 nm in diameter with density of 5/spl times/10/sup 11//cm/sup 2/ were obtained. Threshold voltage shift of 0.48 V corresponding to single electron storage in individual nano-crystals is obtained. For the first time, room temperature single electron effects are observed. These prove the feasibility of practical Si nano-crystal memory.