Miracle-dz/UniFAR-FTUs huggingface dataset:
Effects of a mentalization-informed group intervention with videofeedback for mothers of preschool children

ABSTRACT Early interventions and parenting programs have been found to be the most effective interventions in promoting wellbeing and preventing difficulties during childhood and adulthood, mainly because they operate in a sensitive period. Mentalization-informed and video feedback interventions have shown their effectiveness in caregiver-child relationships. This study aimed to analyze the effect of a preventive mentalization-informed intervention with video feedback on a group of Chilean mothers of preschool children compared with a control group. Fifthy mothers were assessed at baseline and at follow-up. Results showed that mothers of the experimental group reached lower levels of maternal stress and higher use of mental language, and that their children showed lower risk in their socio-emotional development.
Bisexuality and Health Care

Abstract Using data from the fourth wave of the National Study of Adolescent Health, this paper offers a preliminary investigation of factors implicated in the physical and mental health of bisexual individuals. The roles of sleep, socioeconomic status, feelings of disrespect, and reported lack of health insurance are considered. Further, this study examines depression as a psychological stress response and systemic inflammation as a physiological stress response. Systemic inflammation in this population was estimated using the biomarker C-reactive protein (CRP). Reported acute illness in the past month and blood pressure serve as measures of physical health outcomes. Analyses revealed a pattern of elevated CRP (>3mg/L) among participants who reported no health insurance coverage. For participants who reported no health insurance coverage and identified as mostly homosexual, bisexual, or mostly heterosexual, feelings of disrespect were associated both with their sleep outcomes as well as their total household income. Moreover, linear regression showed that CRP significantly predicted blood pressure values. These analyses serve to bring health disparities and specific considerations for individuals attracted to more than one gender further into scientific conversation. Suggestions for further study of bisexual minority stress and bisexual health are offered.
The Mental Health Well-Being of Grandparents Raising Grandchildren: A Systematic Review and Meta-Analysis

Abstract The purpose of this systematic review and meta-analysis was to determine if raising grandchildren is related to diminished mental health well-being in custodial grandparents compared to contemporaries who are not raising grandchildren. Relevant studies were identified via comprehensive literature searches of electronic databases. We included six studies in the meta-analysis. A random effects model was used to calculate effect sizes. The results of the meta-analysis yielded a statistically significant, small-to-moderate summary effect size (ES) indicating caregiving grandparents generally experience a larger degree of adverse mental health outcomes than their non-parenting counterparts. While previous studies have produced conflicting results regarding the mental health outcomes experienced by custodial grandparents, the present meta-analysis findings provide another level of evidence that substantiates their emotional vulnerability. Recommendations for subsequent research are discussed.
Tettigoniidae (Insecta: Orthoptera) collected in tropical forests of Zambia, Cameroon, Gabon and São Tomé during the entomological expeditions of African Natural History Research Trust

Summary The present study is based on a significant sample of Orthoptera, mainly Tettigonoidea, collected by the African Natural History Research Trust in four African countries; a total of 109 taxa was found, of which 32 were in Zambia, 37 in Cameroon, 76 in Gabon and only four in the island of São Tomé. The complete list of species is annotated and commented. Sixteen species (45.7%) were previously unrecorded in Zambia, five (13.5%) in Cameroon, 52 (67.5%) in Gabon, while all the species found at São Tomé were already known from that island. It is evident that Zambia and Gabon are countries unexplored from the orthopterological point of view, in particular because many unrecorded species in these countries are widespread in tropical Africa. The list of the species contains 11 new species; in the present paper six new species are described (Horatosphaga hemporum n. sp., Eulioptera richardsmithi n. sp., Dioncomena takanoi n. sp., Eurycorypha klausgerhardi n. sp., Arantia (Arantia) marginata n. sp. , Tetraconcha fusca n. sp. ), while one species of Leiodontocercus was already described and the description of the others is in progress within the revision of the genus Eurycorypha. Overall, collected material from Zambia contained four new species (12.5%), that from Gabon seven new species (9.2%), of which one is common to Gabon and Cameroon. Based on the results presented here, the orthopterofauna of Gabon is particularly rich and additional sampling will result in the discovery of further unknown species. Interestingly, Desaulcya pictipennis from Gabon was known only from the type material described 113 years before in Cameroon, and Rhinodera spinifrons also from Gabon was known only from the type described 64 years before in Cameroon.
Conceptualizing centers of excellence: A global evidence

Objective: Globally, interest in excellence has grown exponentially, with public and private institutions shifting their attention from meet targets to achieving excellence. Centers of Excellence (CoEs) are standing at the forefront of healthcare, research, and innovations responding to the world's most complex problems. However, their potential is hindered by conceptual ambiguity. We conducted a global synthesis of the evidence to conceptualize CoEs. Design: Scoping review, following Arksey and O Malley's framework and methodological enhancement by Levac et al to analyze the evidence and the PRISMA-ScR to guide the retrieval and inclusion of the evidence. Data sources: PubMed, Scopus, CINAHL, Google Scholar, and the Google engine from their inception to 01 January 2021. Eligibility: Papers that describe CoE as the main theme, which could be defining, theorizing, implementing, or evaluating a CoE. Results: The search resulted in 52,161 potential publications, with 78 articles met the eligibility criteria. The 78 articles were from 33 countries, of which 35 were from the United States of America, 3 each from Nigeria, South Africa, Spain, and India, and 2 each from Ethiopia, Canada, Russia, Colombia, Sweden, Greece, and Peru. The rest 17 were from various countries. The articles involved six thematic areas - healthcare, education, research, industry, information technology, and general concepts on CoE. The analysis documented success stories of using the brand Center of Excellence - an influential brand to stimulate technical skills, innovation, and technology. We identified 12 essential foundations of CoE - specialized expertise; infrastructure; innovation; high-impact research; quality service; accreditation or standards; leadership; organizational structure; strategy; collaboration and partnership; sustainable funding or financial mechanisms; and entrepreneurship. Conclusions: CoEs have significant scientific, political, economic, and social impacts. A comprehensive framework is needed to guide and inspire an institution as a CoE and to help government and funding institutions shape and oversee CoEs. Keywords: Center of Excellence, Innovation, Higher education, Research, Partnership
Sarcopenic obesity and the risk of hospitalisation or death from COVID-19: findings from UK Biobank

Background Coronavirus disease-2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS;CoV-2 virus). The role of skeletal muscle mass in modulating immune response is well documented. Whilst obesity is well-established as a key factor in COVID-19 infection and outcome, no study has examined the influence of both sarcopenia (low muscle mass) and obesity, termed sarcopenic obesity on COVID-19 risk. Methods This study uses data from UK Biobank. Probable sarcopenia was defined as low handgrip strength. Sarcopenic obesity was mutually exclusively defined as the presence of obesity and low muscle mass (based on two established criteria: appendicular lean mass (ALM) adjusted for either: 1) height and 2) body mass index (BMI)). Severe COVID-19 was defined by a positive test result in a hospital setting or death with a primary cause reported as COVID-19. Fully adjusted logistic regression models were used to analyse the associations between sarcopenic status and severe COVID-19. This work was conducted under UK Biobank application number 52553. Results We analysed data from 490,301 UK Biobank participants. 2203 (0.4%) had severe COVID-19 infection. Individuals with probable sarcopenia were 64% more likely to have had severe COVID-19 infection (odds ratio (OR) 1.638; P<. 001). Obesity increased the likelihood of severe COVID-19 infection by 76% (P<.001). Using either ALM index and ALM/BMI index to define low muscle mass, those with sarcopenic obesity were 2.6 times more likely to have severe COVID-19 (OR: 2.619; P<.001). Sarcopenia alone did not increase the risk of COVID-19. Conclusions Sarcopenic obesity may increase the risk of severe COVID-19 infection, over that of obesity alone. The mechanisms for this are complex but could be a result of a reduction in respiratory functioning, immune response, and ability to respond to metabolic stress.
Integrated immunovirological profiling validates plasma SARS-CoV-2 RNA as an early predictor of COVID-19 mortality

Despite advances in COVID-19 management, it is unclear how to recognize patients who evolve towards death. This would allow for better risk stratification and targeting for early interventions. However, the explosive increase in correlates of COVID-19 severity complicates biomarker prioritisation. To identify early biological predictors of mortality, we performed an immunovirological assessment (SARS-CoV-2 viral RNA, cytokines and tissue injury markers, antibody responses) on plasma samples collected from 144 hospitalised COVID-19 patients 11 days after symptom onset and used to test models predicting mortality within 60 days of symptom onset. In the discovery cohort (n=61, 13 fatalities), high SARS-CoV-2 vRNA, low RBD-specific IgG levels, low SARS-CoV-2-specific antibody-dependent cellular cytotoxicity, and elevated levels of several cytokines and lung injury markers were strongly associated with increased mortality in the entire cohort and the subgroup on mechanical ventilation. Model selection revealed that a three-variable model of vRNA, age and sex was very robust at identifying patients who will succumb to COVID-19 (AUC=0.86, adjusted HR for log-transformed vRNA=3.5; 95% CI: 2.0-6.0). This model remained robust in an independent validation cohort (n=83, AUC=0.85). Quantification of plasma SARS-CoV-2 RNA can help understand the heterogeneity of disease trajectories and identify patients who may benefit from new therapies.
Development and validation of the long covid symptom and impact tools, a set of patient-reported instruments constructed from patients’ lived experience

Objectives To develop and validate patient-reported instruments, based on patients' lived experiences, for monitoring the symptoms and impact of long covid. Design The long covid Symptom and Impact Tools (ST and IT) were constructed from the answers to a survey with open-ended questions to 492 patients with long covid. Validation of the tools involved adult patients with suspected or confirmed covid-19 and symptoms extending over three weeks after onset. Construct validity was assessed by examining the relations of the ST and IT scores with health related quality of life (EQ-5D-5L), function (PCFS, post-covid functional scale), and perceived health (MYMOP2). Reliability was determined by a test-retest. The "patient acceptable symptomatic state" (PASS) was determined by the percentile method. Results Validation involved 1022 participants (55% with confirmed covid-19, 79% female and 12.5% hospitalised for covid-19). The long covid ST and IT scores were strongly correlated with the EQ-5D-5L (rs = -0.45 and rs = -0.59 respectively), the PCFS (rs = -0.39 and rs = -0.55), and the MYMOP2 (rs = -0.40 and rs = -0.59). Reproducibility was excellent with an interclass correlation coefficient of 0.83 (95% confidence interval 0.80 to 0.86) for the ST score and 0.84 (0.80 to 0.87) for the IT score. In total, 793 (77.5%) patients reported an unacceptable symptomatic state, thereby setting the PASS for the long covid IT score at 30 (28 to 33). Conclusions The long covid ST and IT tools, constructed from patients' lived experiences, provide the first validated and reliable instruments for monitoring the symptoms and impact of long covid.
Smoking and Vaping Among a National Sample of U.S. Adults During the COVID-19 Pandemic

Introduction: With concerns about cigarette smoking as a risk factor for severe disease from COVID-19, understanding nicotine and tobacco use patterns is important for preventive efforts. We aimed to understand changes in product use behaviors among U.S. adult combustible cigarette smokers and electronic cigarette (e-cigarette) users. Methods: In August 2020, we conducted a cross-sectional survey of a nationally-representative sample of adults age >18 in the NORC AmeriSpeak Panel who reported past 6-month use of combustible cigarettes or e-cigarettes. Multivariable logistic regression assessed factors associated with increased product use and quit attempts since hearing about COVID-19. Results: 1024 past 6-month cigarette smokers and/or e-cigarette users were surveyed. Among cigarette smokers, 45% reported no change in cigarette smoking and 33% increased cigarette smoking since hearing about COVID-19. Higher stress was associated with increased cigarette smoking. Among e-cigarette users, 41% reported no change in and 23% reported increasing e-cigarette use. 26% of cigarette smokers and 41% of e-cigarette users tried to quit because of COVID-19. Higher perceived risk of COVID-19 was associated with attempts to quit combustible cigarettes (AOR 2.37, 95% CI 1.59-3.55) and e-cigarettes (AOR 3.14, 1.73-5.70). Conclusions: Cigarette and e-cigarette use patterns varied in response to the COVID-19 pandemic. Most cigarette smokers and e-cigarette users perceived product use as increasing COVID-19-related health risks, and this was associated with attempts to quit. Others, especially those reporting higher stress, increased product use. Proactive provision of cessation support to smokers and e-cigarette users may help mitigate stress-related increases in product use during the COVID-19 pandemic.
Modeling thermal metrics of importance for native vs non-native fish across stream networks to provide insight for watershed-scale fisheries management

Water temperatures on river networks fluctuate in time and over space. This variation creates complex thermal regimes through which fishes move over the course of their lives. Using water temperature data collected every 30 min for 6 y at 45 locations throughout the Snoqualmie River Basin, Washington, USA, we developed a set of metrics representing facets of the thermal regime important to native Chinook Salmon (Oncorhynchus tshawytscha) and Bull Trout (Salvelinus confluentus) and to non-native Largemouth Bass (Micropterus salmoides) during multiple life-history stages. We modeled these facets using spatial stream network models (SSNMs) built from covariates describing landform, land use, and climate to better understand the potential ecological drivers of thermal habitats for these fishes. The explanatory power (predictive r2) of the final SSNMs ranged from 23 to 97%, with at least ½ the models >69%. The best models tended to include climate and landform covariates, with elevation and mean annual air temperature most often included. The relative contribution of each SSNM component differed by species: thermal metric models for Chinook Salmon tended to have a covariate- and site-based structure, those for Bull Trout tended to have a yearly structure, and those for Largemouth Bass tended to have a spatial structure. We applied our models to map the thermal landscape in ways that should be of particular interest to fish managers. Given the challenging lack of empirical data for rare fish species or fish species that are currently not present, we illustrate how the proliferation of fine-scale temperature data can be leveraged to provide ecological insight. For example, we identified several tributaries and small low-elevation reaches as areas potentially worthy of protection efforts for Chinook Salmon, and we identified the mainstem Snoqualmie River as an area of potential interaction between native salmon and non-native bass.
Behaviour and Strengthening Methods of Tall Slender Columns in Earthquake Conditions

Reinforced concrete buildings are normally designed and constructed with well-defined vertical column supports which are able to withstand both vertical and lateral loadings. In the case of high columns there is a risk of instability due to its slenderness caused by the higher apex ratio (measured by its height in relation to the width). This is compounded by having such buildings located at medium to high seismic risk zones, where lateral dynamic loadings can occur. This research paper focused on how such slender reinforced concrete columns will behave under earthquake loading conditions, and highlights some innovative ways to strengthen the column capacity to withstand both vertical and lateral loadings. Besides the conventional ways to provide diagonal or lateral bracings, the use of glass fibre reinforced polymer (GFRP) as an alternative material for retrofitting tall slender reinforced concrete columns are presented here. The new method includes spraying of the GFRP onto the external surfaces of the columns and also incorporate the GFRP bars as additional reinforcement into the concrete columns. Both methods proved to improve the durability and strengthen the tall reinforced concrete column. This study shows the ability of the new method of amelioration of the slender reinforced concrete columns to increase their stability during seismic activity.
In vitro antilisterial properties of crude aqueous and nhexane extracts of the husk of Cocos nucifera

The in vitro antilisterial activities and time kill regimes of crude aqueous and n-hexane extracts of the husk fiber of Cocos nucifera were assessed. The aqueous extracts were active against 29 of the 37 test Listeria isolates while the n-hexane extracts were active against 30. The minimum inhibitory concentrations (MICs) of all the susceptible bacteria ranged between 0.6 and 2.5 mg/ml for the aqueous fraction and between 0.6 and 5.0 mg/ml for the n-hexane extract. The average log reduction in viable cell count in the time kill assay ranged between 0.32 Log 10 and 3.2 Log 10 cfu/ml after 4 h of interaction, and between 2.6 Log 10 and 4.8 Log 10 cfu/ml after 8 h interaction in 1 × MIC and 2 × MIC (aqueous extract); and between 2.8 Log 10 and 4.8 Log 10 cfu/ml after 4 h of interaction, and 3.5 Log 10 to 6.2 Log 10 cfu/ml after 8 h interaction in 1 × MIC and 2 × MIC for the n-hexane extract. The extract was bactericidal against one of the test bacteria at 1 × MIC and against three of the test bacteria at 2 × MIC for the 8 h interaction period for the aqueous extract, while for the n-Hexane fraction; the extract was bactericidal against all the five test bacteria at both MICs after the 8 h interaction period. We suggested that the crude aqueous and n-hexane extracts of the husk of C. nucifera could be bacteriostatic or bactericidal depending on the time of exposure and concentration. Key words: Cocos nucifera, n-hexane extract, aqueous extract, minimum inhibitory concentration, time-kill.
Severe violations of independence in response inhibition tasks

The keystone assumption of independence in computational models for response inhibition is severely violated. The stop-signal paradigm, a primary experimental paradigm for understanding cognitive control and response inhibition, rests upon the theoretical foundation of race models, which assume that a go process races independently against a stop process that occurs after a stop-signal delay (SSD). We show that severe violations of this independence assumption at short SSDs occur systematically across a wide range of conditions, including fast and slow reaction times, auditory and visual stop signals, manual and saccadic responses, and especially in selective stopping. We also reanalyze existing data and show that conclusions can change when short SSDs are excluded. Last, we suggest experimental and analysis techniques to address this violation, and propose adjustments to extant models to accommodate this finding.
Discussion of ‘Seismic imaging of mélanges; Pieniny Klippen Belt case study’, Journal of the Geological Society, London, https://doi.org/10.1144/jgs2018-220

Edyta Jurewicz1*, Tomasz Segit1, Dušan Plašienka2 and Kajetan Chrapkiewicz3 1 Faculty of Geology, University of Warsaw, Al. Żwirki i Wigury 93, 02-089 Warsaw, Poland 2 Department of Geology and Palaeontology, Faculty of Natural Sciences, Comenius University, Mlynská dolina, Ilkovičova 6, 842 15 Bratislava, Slovakia 3 Faculty of Engineering, Department of Earth Science & Engineering, Imperial College London, London SW7 2AZ, UK EJ, 0000-0002-5993-7098; TS, 0000-0003-2952-6332 *Correspondence: edyta.jurewicz@uw.edu. pl
GREB1: An evolutionarily conserved protein with a glycosyltransferase domain links ERα glycosylation and stability to cancer

GREB1 is an inducible cytoplasmic glycosyltransferase. What covalent modifications control the temporal ubiquitination of ERα and hence the duration of its transcriptional activity remain poorly understood. We show that GREB1, an ERα-inducible enzyme, catalyzes O-GlcNAcylation of ERα at residues T553/S554, which stabilizes ERα protein by inhibiting association with the ubiquitin ligase ZNF598. Loss of GREB1-mediated glycosylation of ERα results in reduced cellular ERα levels and insensitivity to estrogen. Higher GREB1 expression in ERα+ve breast cancer is associated with greater survival in response to tamoxifen, an ERα agonist. Mice lacking Greb1 exhibit growth and fertility defects reminiscent of phenotypes in ERα-null mice. In summary, this study identifies GREB1, a protein with an evolutionarily conserved domain related to DNA-modifying glycosyltransferases of bacteriophages and kinetoplastids, as the first inducible and the only other (apart from OGT) O-GlcNAc glycosyltransferase in mammalian cytoplasm and ERα as its first substrate.
Asia-Europe intimate links: Family migrants, binational couples and mixed-parentage children

The social unit of the family has been one of the principal channels and drivers of contemporary migration. The family-shaped movement of people is known in the literature as “family-related migration” (Kofman, 2004), and more recently as “family migration” (Cooke, 2008)—“migration events that are made within the context of a family” and/or “with respect to events in the lives of distant, extended family members” (Cooke, 2008: 260). This phenomenon includes family formation, family reunification, accompanying family and international adoption (Migration Data Portal, 2020). It takes place alongside or overlaps with other migratory movements such as labor, student, climate-/war-induced and sexual migrations. Among the migration corridors