Miracle-dz/UniFAR-FTUs huggingface dataset:
Interaction of Dietary Sodium-to-potassium Ratio and Dinner Energy Ratio on Prevalence of Hypertension in Inner Mongolia, China

Background Hypertension is one of the most common chronic diseases, and dietary factors play an important role in hypertension. We examined the interaction of dietary sodium-to-potassium (Na/K) ratio and dinner energy ratio on hypertension. Methods We conducted this study using data from the cross-sectional National Survey for Nutrition and Adult Chronic Disease in 2015 in Inner Mongolia, China. Dietary data were collected using 24-hour diet records with food weights across 3 consecutive days. Logistic regression was used to determine the interaction of dinner energy ratio and dietary Na/K ratio on hypertension. Results A total of 1,861 participants were included in this study, and 914 individuals were hypertensive (49.1%). Dinner energy ratio and high dietary Na/K ratio were independently related to high prevalence of hypertension. A formal test showed that dinner energy ratio interacted significantly with dietary Na/K ratio on hypertension (P < 0.001), with an adjusted odds ratio (OR) of 1.119 (95% confidence interval [CI], 1.040–1.203). Participants whose dinner energy ratio greater than 39.1% and dietary Na/K ratio of 3.625–6.053 had the highest OR of hypertension prevalence, with an adjusted OR of 2.984 (95% CI, 1.758–5.066), compared with participants with dinner energy ratio of 30.2–39.1%, and dietary Na/K ratio less than 2.348. Conclusion Our study highlighted the interactive effect of dinner energy ratio and dietary Na/K ratio on hypertension among adults in Inner Mongolia. We advocated a balanced diet (dinner energy ratio not small or large) and a low dietary Na/K ratio for reducing the prevalence of hypertension.
Single-cell analyses reveal early thymic progenitors and pre-B cells in zebrafish

Single-cell RNA sequencing of zebrafish hematopoiesis provides new insights into zebrafish B- and T-cell development and cellular diversity within the primary lymphoid organs (kidney marrow and thymus). This work advances the current understanding of zebrafish immunology and will facilitate future genetic and developmental studies.
Real-world survival outcomes in patients with locally advanced or metastatic NTRK fusion-positive solid tumors receiving standard-of-care therapies other than targeted TRK inhibitors

The clinical profiles and outcomes of patients with neurotrophic tropomyosin receptor kinase fusion-positive (NTRK+) solid tumors receiving standard of care other than tropomyosin receptor kinase inhibitor (TRKi) targeted therapy have not been well documented. Here, we describe the clinical characteristics of patients with NTRK+ tumors treated in clinical practice using information from a United States electronic health record-derived clinicogenomic database. We also compared survival outcomes in NTRK+ patients and matched NTRK fusion-negative (NTRK–) patients and investigated the clinical prognostic value of NTRK fusions. NTRK positivity was defined by the presence of a fusion or rearrangement involving NTRK1/2/3, determined using NGS (Foundation Medicine, Inc.). NTRK+ patients (n = 28) were diagnosed with locally advanced/metastatic solid tumors between January 1, 2011 and December 31, 2019 and had received no TRKis (e.g., entrectinib or larotrectinib) during their patient journey. The unselected NTRK−population comprised 24,903 patients, and the matched NTRK−cohort included 280 patients. NTRK+ patients tended to be younger, were more commonly not smokers, and had a shorter time from advanced diagnosis to first NGS report, compared with unselected NTRK−patients; however, these differences were not significant. Median overall survival (OS) from advanced/metastatic diagnosis was 10.2 months (95% CI, 7.2–14.1) for the NTRK+ cohort versus 10.4 months (95% CI, 6.7–14.3) for the matched NTRK−cohort; hazard ratio for death in NTRK+ versus matched NTRK−patients was 1.6 (95% CI, 1.0–2.5; P = 0.05). Genomic co-alterations were rare in the NTRK+ cohort (only two of 28 patients had a co-alteration). Overall, while hazard ratios suggest NTRK fusions may be a negative prognostic factor of survival, there are no significant indications of any favorable impact of NTRK fusions on patient outcomes. TRKis, with their high response rate and good tolerability, are likely to improve outcomes for patients compared with existing standard-of-care treatments.
Environmental dependence of stellar mass, SFR, and SSFR for the Luminous Red Galaxy (LRG) sample of the SDSS DR7

Using the Luminous Red Galaxy (LRG) sample of the Sloan Digital Sky Survey Data Release 7 (SDSS DR7), we investigate the environmental dependence of stellar mass, star formation rate (SFR) and specific star formation rate (SSFR) of LRGs. It is found that stellar mass of LRGs nearly is independent of local environments, and that the environmental dependence of SFR and SSFR in the LRG sample is much weaker than the one in the Main galaxy sample. One possible explanation is that galaxy color and morphology are a pair of galaxy properties most predictive of local environments, while LRGs are a group of galaxies that are likely to be luminous, red and of early types (© 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)
Wide range of phenotypic severity in individuals with late truncations unique to the predominant CDKL5 transcript in the brain

Cyclin‐dependent kinase‐like 5 (CDKL5) deficiency disorder (CDD) is caused by heterozygous or hemizygous variants in CDKL5 and is characterized by refractory epilepsy, cognitive and motor impairments, and cerebral visual impairment. CDKL5 has multiple transcripts, of which the longest transcripts, NM_003159 and NM_001037343, have been used historically in clinical laboratory testing. However, the transcript NM_001323289 is the most highly expressed in brain and contains 170 nucleotides at the 3′ end of its last exon that are noncoding in other transcripts. Two truncating variants in this region have been reported in association with a CDD phenotype. To clarify the significance and range of phenotypes associated with late truncating variants in this region of the predominant transcript in the brain, we report detailed information on two individuals, updated clinical information on a third individual, and a summary of published and unpublished individuals reported in ClinVar. The two new individuals (one male and one female) each had a relatively mild clinical presentation including periods of pharmaco‐responsive epilepsy, independent walking and limited purposeful communication skills. A previously reported male continued to have a severe phenotype. Overall, variants in this region demonstrate a range of clinical severity consistent with reports in CDD but with the potential for milder presentation.
Templates for the Solution of Algebraic Eigenvalue Problems

List of symbols and acronyms List of iterative algorithm templates List of direct algorithms List of figures List of tables 1: Introduction 2: A brief tour of Eigenproblems 3: An introduction to iterative projection methods 4: Hermitian Eigenvalue problems 5: Generalized Hermitian Eigenvalue problems 6: Singular Value Decomposition 7: Non-Hermitian Eigenvalue problems 8: Generalized Non-Hermitian Eigenvalue problems 9: Nonlinear Eigenvalue problems 10: Common issues 11: Preconditioning techniques Appendix: of things not treated Bibliography Index .
Stunting and Associated Factors Among 6-23 Months Age Children in Ethiopia: Application of Generalized Linear Latent and Mixed Modeling

ABSTRACT Low height/length-for-age (stunting) is a public health problem in Ethiopia. Efforts that have been made to evaluate factors affecting national and international strategies related to the problem are very limited and poorly achieved. The present study aimed to evaluate low length/height-for-age (stunting) and its associated factors among children 6 to 23 months of age in Ethiopia. We used cross-sectional data collected for 2019 EMDHS. We cleaned, processed, and analyzed in Stata v.15. Socio-demographic, socio-economic parameters, and nutritional (wasting, diet frequency, breast milk, and animal milk) factors were used in the analysis. We fitted Generalized Linear Latent and Mixed Model (GLLAMM) to examine the associations. We analyzed the data of 2,037 children aged 6–23 months and found stunting of 933.07(45.80%). Some factors such as home delivery [coef. = −4.58, 95% CI:-7.81,-1.34] and household size of ≥6 [coef. = −5.53, 95% CI:-10.36,-7.10] were positively associated. No current breastfeeding [coef. = 10.70, 95% CI: 2.16, 19.23] and still breastfeed [coef. = 10.68, 95% CI: 2.62, 18.74] were negatively associated with stunting. Stunting among 6–23 months aged children in Ethiopia is very high above all the national, regional, and international targets. Feeding practice, socio-economic, and psychosocial-support for mothers need revised commitment for pragmatic solution.
The Interplay of Personality Traits and Social Network Characteristics in the Subjective Well-Being of Older Adults

Using data from the Survey of Health, Ageing and Retirement in Europe, we regressed three well-being measures (CASP, life satisfaction and Euro-D depressive symptoms) on indicators of personality and social network. Personality was indicated by the Big-Five personality traits, while social network was measured in terms of size, contact frequency and emotional closeness. The analysis also considered personality—network interactions, controlling for confounders. The sample was comprised of 35,145 adults, aged 50 and older, from 24 European countries and Israel. The results revealed that the personality traits explained more variance in the well-being outcomes than the social network characteristics did. However, the interactions showed that the social network characteristics, particularly size and mean emotional closeness, offset the effects of dysfunctional personality attributes on subjective well-being in late life. Hence, social network characteristics were shown to modify the potentially ill effects of personality on key well-being indicators.
Barriers and facilitators of weight management: Perspectives of the urban poor in Accra, Ghana

Background Obesity is rising in sub-Saharan Africa and globally, and is a highly significant public health problem that needs urgent attention. To reduce the obesity prevalence levels and associated challenges, public health interventions highlight healthy eating and increased physical activity, which are key elements for weight management. Aim This study explored perceived factors that hinder or facilitate weight management in an urban poor context in Accra, Ghana. Methods A cross-sectional qualitative data was obtained from eight focus group discussions (FGDs) conducted among community members. The FGDs were audio recorded, transcribed, and analysed using thematic analysis. Results The findings indicate that weight management is mainly inhibited by the perception that healthy foods are expensive and not satisfying, laziness, lack of time to engage in physical activity, and social representation of being fat or slim. On the contrary, personal decision to manage weight and social support facilitated engagement in weight management. Conclusion The findings indicate that weight management is influenced by individual, community, and structural factors. These findings have programmatic implications in terms of health education strategies and messaging.
Influence of material heterogeneity on the mechanical response of articulated cartilages in a knee joint

Structurally, the articular cartilages are heterogeneous owing to nonuniform distribution and orientation of its constituents. The oversimplification of this soft tissue as a homogeneous material is generally considered in the simulation domain to estimate contact pressure along with other physical responses. Hence, there is a need for investigating knee cartilages for their actual response to external stimuli. In this article, impact of material and geometrical heterogeneity of the cartilage is resolved using well known material models. The findings are compared with conventional homogeneous models. The results indicate vital differences in contact pressure distribution and tissue deformation. Further, this study paves way for standardizing material models to extract maximum information possible for investigating knee mechanics with variable geometry and case specific parameters.
Keys to well-being in older adults during the COVID-19 pandemic: personality, coping and meaning

ABSTRACT Purpose During the COVID-19 pandemic, older adults were portrayed as an at-risk group. While this may have been true in some respects, empirical studies on mental health, including well-being were conflicting. Some studies found that older adults demonstrated a notable emotional resilience against the impacts of the pandemic. In this study, we qualitatively examine how older adults understand well-being and how they approached pandemic’s potential influence on their well-being. Methods 17 older adults participated in the study, out of which 14 were interviewed and three provided written responses to a set of questions. Results and conclusions Through Interpretative Phenomenological Analysis, three themes emerged:adaptation, control, and a sense of community. We use them to discuss three central questions within well-being theory and research: How far does well-being depend on personal traits and how far does it depend on the environment? How far do people adapt to changed circumstances, and how far is such adaption conducive to maintaining genuine well-being and not just a lowering of standards of comparison? How far does subjective well-being depend on individual and momentary experiences and how far does it depend on the larger temporal and social context of an individual?
integrin inhibition dramatically enhances radiotherapy efficacy in human breast cancer xenografts

β 1 integrin signaling has been shown to mediate cellular resistance to apoptosis after exposure to ionizing radiation (IR). Other signaling molecules that increase resistance include Akt, which promotes cell survival downstream of β 1 integrin signaling. We showed previously that β 1 integrin inhibitory antibodies, AIIB2, enhance apoptosis and decrease growth in human breast cancer cells in 3 dimensional laminin-rich extracellular matrix (3D lrECM) cultures and in vivo . Here we asked whether AIIB2 could synergize with IR to modify Akt-mediated IR resistance. We used 3D lrECM cultures to test the optimal combination of AIIB2 with IR treatment of two breast cancer cell lines, MCF-7 and HMT3522-T4-2, as well as T4-2 myr-Akt breast cancer colonies or HMT3522-S-1, which form normal organotypic structures in 3D lrECM. Colonies were assayed for apoptosis and β 1 integrin/Akt signaling pathways were evaluated using western blot. In addition, mice bearing MCF-7 xenografts were used to validate the findings in 3D lrECM. We report that AIIB2 increased apoptosis optimally post-IR by down regulating Akt in breast cancer colonies in 3D lrECM. tumor growth plus similar to that 8 Gy alone. We showed previously that AIIB2 had no discernible toxicity in mice; here, its addition allowed for a significant reduction in the IR dose that was necessary to achieve comparable growth inhibition and apoptosis in breast cancer xenografts vivo
Separating the effects of air and soil temperature on silver birch. Part II. The relation of physiology and leaf anatomy to growth dynamics

Abstract The aboveground parts of boreal forest trees grow earlier in the growing season, the roots mostly later. The idea was to examine whether root growth followed soil temperature, or whether shoot growth also demanded most resources in the early growing season (soil temperature vs internal sink strengths for resources). The linkage between air and soil temperature was broken by switching the soil temperature. We aimed here to identify the direct effects of different soil temperature patterns on physiology, leaf anatomy and their interactions, and how they relate to the control of the growth dynamics of silver birch (Betula pendula Roth). Sixteen 2-year-old seedlings were grown in a controlled environment for two 14-week simulated growing seasons (GS1, GS2). An 8-week dormancy period interposed the GSs. In GS2, soil temperature treatments were applied: constant 10 °C (Cool), constant 18 °C (Warm), early growing season at 10 °C switched to 18 °C later (Early Cool Late Warm) and 18 °C followed by 10 °C (Early Warm Late Cool) were applied during GS2. The switch from cool to warm enhanced the water status, net photosynthesis, chlorophyll content index, effective yield of photosystem II (ΔF/Fm′) and leaf expansion of the seedlings. Warm treatment increased the stomatal number per leaf. In contrast, soil cooling increased glandular trichomes. This investment in increasing the chemical defense potential may be associated with the decreased growth in cool soil. Non-structural carbohydrates were accumulated in leaves at a low soil temperature showing that growth was more hindered than net photosynthesis. Leaf anatomy differed between the first and second leaf flush of silver birch, which may promote tree fitness in the prevailing growing conditions. The interaction of birch structure and function changes with soil temperature, which can further reflect to ecosystem functioning.
Postsecondary Faculty Attitudes and Beliefs about Writing-Based Pedagogies in the STEM Classroom

Writing is an important skill for communicating knowledge in science, technology, engineering, and mathematics (STEM) and an aid to developing students’ communication skills, content knowledge, and disciplinary thinking. Despite the importance of writing, its incorporation into the undergraduate STEM curriculum is uneven. Research indicates that understanding faculty beliefs is important when trying to propagate evidence-based instructional practices, yet faculty beliefs about writing pedagogies are not yet broadly characterized for STEM teaching at the undergraduate level. Based on a nationwide cross-disciplinary survey at research-intensive institutions, this work aims to understand the extent to which writing is assigned in undergraduate STEM courses and the factors that influence faculty members’ beliefs about, and reported use of, writing-based pedagogies. Faculty attitudes about the effectiveness of writing practices did not differ between faculty who assign and do not assign writing; rather, beliefs about the influence of social factors and contextually imposed instructional constraints informed their decisions to use or not use writing. Our findings indicate that strategies to increase the use of writing need to specifically target the factors that influence faculty decisions to assign or not assign writing. It is not faculty beliefs about effectiveness, but rather faculty beliefs about behavioral control and constraints at the departmental level that need to be targeted.
Serum Cystatin C for Estimation of GFR.

An 80-year-old man with type 2 diabetes and hypertension was referred to the nephrology clinic for assessment of persistent hyperkalemia despite discontinuation of his angiotensin-converting enzyme inhibitor. The patient was frail, sedentary, and had a body mass index of 37. Select blood testing results are shown in Table 1. His estimated glomerular filtration rate (eGFR) was calculated using 3 equations that incorporated creatinine (eGFRcr), cystatin C (eGFRcys), and both creatinine and cystatin C (eGFRcr-cys), as shown in Table 2.
Fetal Thymus and Migration of Fetal Liver Cells to the Roles of Integrins and CD44 on the Adhesion

2 Adhesion and migration of mouse fetal liver (FL) cells to the thymus were investigated using cells from green ﬂuorescent protein transgenic (GFP 1 ) mice. FL cells from GFP 1 embryos at 12 gestational days (E12) of mice were incubated with 2 * -deox-yguanosine-treated fetal thymus lobe (from E14) by thymic repopulation (hanging drop) culture methods. GFP 1 cells were observed in the thymus lobe at the end of the repopulation culture period. A large part of the inﬁltrated cells expressed CD44 until day 2 of culture on a permeable membrane, then lost the expression. CD25 expression was observed from day 1 to day 4. Around day 8, GFP 1 cells became both CD4 1 and CD8 1 . The results support the early observation of the sequential expression of CD44, CD25, and CD4/8 during the early stages of thymocyte development. When anti-CD44 mAb was added at the beginning of the repopulation culture period, GFP 1 FL cells adhered to the surface of the thymus lobe but did not migrate into the thymus. Pretreatment of the thymus with hyaluronidase or hyaluronate produced results similar to the results of anti-CD44 treatment. On the other hand, the addition of anti-integrin a 4 mAb inhibited adhesion to the thymus, and almost no GFP 1 cells were seen on the surface of the thymus lobe. The data suggest that integrin a 4 and CD44 play different roles, i.e., integrin a 4 is required for the adhesion of FL cells to the thymus lobe and CD44 is required for the migration of the cells into the thymus.
Comparison of circulating miR-148a and miR-126 with autoantibodies as biomarkers of lupus nephritis in patients with SLE

ABSTRACT Lupus nephritis (LN) is the main manifestation of systemic Lupus Erythematosus (SLE). MicroRNAs (miRNAs) and autoantibodies could be suitable candidate biomarkers of LN. This study evaluates the expression of circulating miR-148a and miR-126 along with anti-dsDNA, anti-C1q, and anti-C3b autoantibodies in SLE patients with LN (SLE + LN). 30 women with SLE, 30 women with SLE + LN, and 25 women as healthy controls (HCs) were enrolled in this study. The plasma expression of selected miRNAs was evaluated by real-time PCR. The serum level of anti-dsDNA, C1q, and C3b antibodies was measured by the ELISA. The expression of miR-148a was significantly increased in SLE and SLE+LN groups compared with the control group. No significant difference was found in the expression of miR-126 among the groups. The frequency of autoantibodies was significantly higher in the SLE + LN group than SLE. The Higher levels of circulating miR-148a in the SLE samples compared with the HCs suggest that this miRNA could be a reliable biomarker for SLE patients (with or without LN). Also, autoantibodies against dsDNA, C1q, and, C3 could be used for the prediction of SLE nephritis, independently. However, further studies are needed to confirm these findings.