Miracle-dz/UniFAR-FTUs huggingface dataset:
RESEARCH PAPER a 1 -Adrenoceptors are required for normal male sexual function

Background and purpose: a 1 -Adrenoceptor antagonists are extensively used in the treatment of hypertension and lower urinary tract symptoms associated with benign prostatic hyperplasia. Among the side effects, ejaculatory dysfunction occurs more frequently with drugs that are relatively selective for a 1A -adrenoceptors compared with other drugs of this class. This suggests that a 1A -adrenoceptors may contribute to ejaculation. However, this has not been studied at the molecular level. Experimental approach: The physiological contribution of each a 1 -adrenoceptor subtype was characterized using a 1 -adrenoceptor subtype-selective knockout (KO) mice ( a 1A -, a 1B - and a 1D -AR KO mice) since the subtype-specific drugs available are only moderately selective. We analysed the role of a 1 -adrenoceptors in the blood pressure and vascular response as well as ejaculation by determining these variables in a 1 -adrenoceptor subtype-selective KO mice and in mice with all their a 1 -adrenoceptor subtypes deleted ( a 1 -AR triple-KO mice). Key results: The pregnancy rate was reduced by 50% in a 1A -adrenoceptor KO mice, and this reduction was dramatically enhanced in a 1 -adrenoceptor triple-KO mice. Contractile tension of the vas deferens in response to noradrenaline was markedly decreased in a 1A -adrenoceptor KO mice, and this contraction was completely abolished in a 1 -adrenoceptor triple-KO mice. This attenuation of contractility was also observed in the electrically stimulated vas deferens. Conclusions and implications: These results demonstrate that a 1 -adrenoceptors, particularly a 1A -adrenoceptors, are required for normal contractility of the vas deferens and consequent sperm ejaculation as well as having a function in fertility. role -adrenoceptors ejaculation, each -adrenoceptor subtype all a -adrenoceptor subtypes -AR triple-KO mice). -adrenoceptors,
Original Contribution A Cross-Sectional Analysis of Telomere Length and Sleep in theWomen’s Health Initiative

Telomere length is a heritable marker of cellular age that is associated with morbidity and mortality. Poor sleep behaviors, which are also associated with adverse health events, may be related to leukocyte telomere length (LTL). We studied a subpopulation of 3,145 postmenopausal women (1,796 European-American (EA) and 1,349 African-American (AA)) enrolled in the Women’s Health Initiative in 1993–1998 with data on Southern blotmeasured LTL and self-reported usual sleep duration and sleep disturbance. LTL-sleep associations were analyzed separately for duration and disturbance using weighted and confounder-adjusted linear regression models in the entire sample (AAs + EAs; adjusted for race/ethnicity) and in racial/ethnic strata, since LTL differs by ancestry. After adjustment for covariates, each additional daily hour of sleep beyond 5 hours, approximately, was associated with a 27-base-pair (95% confidence interval (CI): 6, 48) longer LTL in the entire sample. Associations between sleep duration and LTL were strongest among AAs (adjusted β = 37, 95% CI: 4, 70); a similar, nonsignificant association was observed for EAs (adjusted β = 20, 95% CI: −7, 48). Sleep disturbance was not associated with LTL in our study. Our models did not show departure from linearity (quadratic sleep terms: P ≥ 0.55). Our results suggest that longer sleep duration is associated with longer LTL in postmenopausal women.
OPTH_A_370033 2025..2032

Purpose: To assess the topographic and visual outcomes of corneal cross-linking (CXL) for post-LASIK ectasia. Methods: A retrospective case series of patients who had progressive post-LASIK ectasia, with at least 2 years of follow-up. They had epithelium-off CXL. Topographical and visual changes were recorded. Results: The study included 21 eyes of 11 patients. At month 24, the final logMAR corrected distance visual acuity (CDVA) and spherical equivalent (SE) were stable compared to baseline (0.16, and −2.0 diopter (D), respectively). The final Kmean and Kmax were 42.5 and 47.4 D, respectively. Stability or improvement in CDVA, SE, and Kmax was seen in 17 eyes (81%). Significant corneal thinning was seen (438 vs 457 microns, p = 0.003). Thinning by 2% or more was seen in 12 eyes (57.1%). Failure of CXL was seen in 4 eyes (19%). No other ocular complications were seen. Conclusion: CXL for post LASIK ectasia is a safe and effective modality. Despite corneal thinning, there was stability or improvement in topographic parameters and CDVA over the 2-year follow-up period.
Genome-Wide Association Analysis of Body Mass in Chronic Obstructive Pulmonary Disease of the Evaluation of Chronic Obstructive Pulmonary Disease Longitudinally to Identify Predictive Surrogate End-Points (ECLIPSE), Norway-Bergen cohort, National Emphysema Treatment Trial, and COPD Gene investigator

Cachexia, whether assessed by body mass index (BMI) or fat-free mass index (FFMI), affects a signiﬁcant proportion of patients with chronic obstructive pulmonary disease (COPD), and is an indepen- dent risk factor for increased mortality, increased emphysema, and more severe airﬂow obstruction. The variable development of cachexia among patients with COPD suggests a role for genetic susceptibility. The objective of the present study was to determine genetic susceptibility loci involved in the development of low BMI and FFMI in subjects with COPD. A genome-wide association study (GWAS) of BMI was conducted in three independent cohorts of European descent with Global Initiative for Chronic Obstructive Lung Disease stage II or higher COPD: Evaluation of COPD Longitudinally to Identify Predictive Surrogate End-Points (ECLIPSE; n 5 1,734); Norway-Bergen cohort ( n 5 851); and a subset of subjects from the National Emphysema Treatment Trial (NETT; n 5 365). A genome-wide association of FFMI was conducted in two of the cohorts (ECLIPSE and Norway). In the combined analyses, a signiﬁcant association was found between rs8050136, located in the ﬁrst intron of the fat mass and obesity–associated ( FTO) gene, and BMI ( P 5 4.97 3 10 2 7 ) and FFMI ( P 5 1.19 3 10 2 7 ). We replicated the association in a fourth, independent cohort consisting of 502 sub- jects with COPD from COPDGene ( P 5 6 3 10 2 3 ). Within the largest contributing cohort of our analysis, lung function, as assessed by forced expiratory volume at 1 second, varied signiﬁcantly by FTO genotype. Our analysis suggests a potential role for the FTO locus in the determination of anthropomorphic measures associated with COPD.
Synthesis of Hemoglobin A,, and Related Minor Hemoglobins by Erythrocytes IN VITRO STUDY OF REGULATION

ofthis study have been presented at the 1978 Meeting of the Southern Society for Clinical Investigation, New Orleans, La. (1978. Clin. Res. 26: 60A.), at the 38th Annual Meeting of the American Diabetes Association, Boston, Mass. (1978. Diabetes. 27: 433.), and at the meeting "Electrofocus '78" sponsored by LKB Instruments Inc., Atlanta, Fla. Portions of this study were submitted by Dr. Spicer in partial fulfillment of the requirements for the Ph.D. degree at the Medical University of South Carolina.
Polytriazine imide-LiCl semiconductor for highly efficient photooxidation of benzyl alcohol to benzaldehyde

Ionothermal synthesis of carbon nitride paved the way to a new structural allotrope—polytriazine imide. In this work, we screen available precursors for pristine polytriazine imides and for their graphitic analogs narrowing it to the melamine—urea mixture as the most promising starting material. Photocatalytic activity of materials verified in reaction of benzyl alcohol oxidation to benzaldehyde, which is known to be highly requested chemical with thousands of tons of annual production. Therefore ‘‘green’’ and selective route of production is highly desired. Developed PTI-LiCl was tested for selective photooxidation of benzyl alcohol to benzaldehyde, demonstrating precious conversion and selectivity rates—96.3% and 91.6%, respectively after 5 hours of UV irradiation. Detailed physical-chemical characterization revealed that PTI materials possessed more ordered and highly condensed structure which grant them improved photocatalytic properties in comparison to graphitic carbon nitride polymorph.
The phenomenon of “clip thinking” in the educational and cognitive activities of students of natural and physical-mathematical educational profile

The article presents an analysis of the phenomenon of “clip thinking” in the educational and cognitive activities of students of natural and physical-mathematical educational profile. The involvement of clip thinking in the initial stage of cognition in comparison with rational and theoretical thinking is theoretically substantiated. An empirical verification of the originality of cognitive processes of students of natural and physical-mathematical educational profile in the situation of comparing traditional linear (textual) and hypertextual way of presenting information is established. Deficiency of cognitive processes characteristic of clip thinking for results is revealed, which is characterized by characteristics of mental (theoretical) level of cognition. Therefore, the next stage of cognition should be the understanding of information through the mechanisms of comparison, generalization, categorization and re-synthesis.
Multiframe Correction Blind Deconvolution for Solar Image Restoration

A series of short-exposure images are often used for rich, small-scale structure, high-quality, and high-resolution astronomical observations. Postprocessing of the closed-loop adaptive optics (AO) image using ground-based astronomical telescopes plays an important role in astronomical observations due to it further improving image quality after AO processing. These images show several main characteristics: random spatial variation blur kernel, unclear model after AO correction, unclear physical characteristics of observation objects, etc. Our goal is to propose a multiframe correction blind deconvolution (MFCBD) algorithm to restore AO closed-loop solar images. MFCBD introduces a denoiser and corrector to help estimate the intermediate latent image and proposes using an L q norm of the kernel as the sparse constraint to acquire a compact blur kernel. MFCBD also uses the half-quadratic splitting strategy to optimize the objective function, which makes the algorithm not only simple to solve, but also easy to adapt to different fidelity terms and prior terms. In tests on three data sets observed from the photosphere and chromosphere of the Sun, MFCBD not only restored clearer and more detailed images, but also converged smoothly and monotonically in terms of the peak signal-to-noise ratio (PSNR) and structural similarity (SSIM) after a few iterations. Taking the speckle-reconstructed image as a reference, the clear image restored by our method performs best both in PSNR and SSIM compared with the state-of-the-art traditional methods OBD and BATUD.
Predictors of Linkage to HIV Care and Viral Suppression Levels Following Release from Jails and Prisons: A Retrospective Cohort Study

Background— Incarceration can offer the opportunity for HIV care engagement, but is associated with poor HIV treatment outcomes after release. This study comprehensively assesses post-release linkage to HIV care (LTC) and the impact of transitional case management services. Methods— To create a retrospective cohort of all adults with HIV released from Connecticut jails and prisons (2007–2014), we linked administrative custody and pharmacy databases with mandatory HIV/AIDS surveillance monitoring and case management data. We examined time to LTC (defined as first post-release HIV-1 RNA level) and viral suppression at time of LTC. Generalized estimating equations identified predictors of LTC within 14 and 30 days post-release. Findings— Among 3,302 incarceration periods for 1,350 individuals, 21.1% (n=672/3181) and 34.0% (n=1042/3064) had LTC within 14 and 30 days post-release, respectively, and 28.9% (n=301/1042) had detectable viral levels at LTC. Factors positively associated with 14-day LTC included intermediate incarceration duration (31–364 days), year of release, transitional case management (reported in 34.2% [n=1128/3302] of releases), receipt of within-prison antiretroviral medications, and higher medical co-morbidity. Re-incarceration and conditional release were negatively associated with LTC. Race/ethnicity, bonded release, and psychiatric co-morbidity were additionally associated with 30-day LTC, but re-incarceration was not. LTC post-release when inmates’ medical, psychiatric, and case management are identified and addressed before release. Persons rapidly cycling through jail facilities are to missed linkage Aligning justice and integrated great to improve long-term HIV treatment USA using multiple administrative databases, this study confirms that LTC is suboptimal, but identifies salient targets for intervention. We show that the consistent targeted provision of transitional case management and integration of healthcare and CJ services are key to improving HIV treatment outcomes during and following the transition to community settings.
COPD_A_364932 1409..1421

1Integrative Toxicology, The National Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; 2Department of Public Health and Caring Sciences, Family Medicine and Preventive Medicine, Uppsala University, Uppsala, Sweden; 3Novartis Pharma AG, Basel, Switzerland; 4IQVIA Solutions, Copenhagen, Denmark; 5IQVIA Solutions, Solna, Sweden; 6Department of Medical Sciences: Respiratory, Allergy and Sleep Research, Uppsala University, Uppsala, Sweden
Analyzing How BERT Performs Entity Matching

State-of-the-art Entity Matching (EM) approaches rely on transformer architectures, such as BERT , for generating highly contex-tualized embeddings of terms. The embeddings are then used to predict whether pairs of entity descriptions refer to the same real-world entity. BERT-based EM models demonstrated to be effective, but act as black-boxes for the users, who have limited insight into the motivations behind their decisions. In this paper, we perform a multi-facet analysis of the components of pre-trained and fine-tuned BERT architectures applied to an EM task. The main findings resulting from our extensive experimental evaluation are (1) the fine-tuning process applied to the EM task mainly modifies the last layers of the BERT components, but in a different way on tokens belonging to descriptions of matching / non-matching entities; (2) the special structure of the EM datasets, where records are pairs of entity descriptions is recognized by BERT; (3) the pair-wise semantic similarity of tokens is not a key knowledge exploited by BERT-based EM models.
Vitex doniana root bark, stem bark and leaves extracts against CCl4-induced liver damage in rats

Liver diseases remain one of the major threats to public health and a worldwide problem[1]. The World health organization estimates that 46% of global disease and 59% of mortality are due to chronic disease[2] and the management of liver disease is still a challenge to the modern medicine since modern medicine has little to offer alleviation of hepatic ailments[3]. Liver is the most important organ, which plays a pivotal role in regulating various physiological processes in the body. It is the organ in charge of many important life functions, including food digestion, glycogen storage, control of metabolism, drug detoxification and hormone PEER REVIEW ABSTRACT
COPD_A_361256 1423..1430

1Pneumology and Critical Care Medicine, Thoraxklinik at University of Heidelberg, Heidelberg, Germany; 2Institute for Medical Statistics, Center for Medical Statistics, Informatics and Intelligent Systems, Medical University Vienna, Vienna, Austria; 3Medizinische Klinik V, Klinikum Fulda, Fulda, Deutschland; 4Pneumologie & Internistische Intensivmedizin, Asklepios Klinik Barmbek, Hamburg, Deutschland; 5Translational Lung Research Center Heidelberg (TLRCH, German Center for Lung Research (DZL), Heidelberg, Germany; 6Department of Internal Medicine II, Division of Pulmonology, Medical University of Vienna, Vienna, Austria
Effectiveness of an Upper and Lower Limb Resistance Training Program on Body Composition, Nerve Conduction Velocity, and Cardiac Autonomic Nervous Activity in University Athletes

Padkao T, Prasertsri P. Effectiveness of an Upper and Lower Limb Resistance Training Program on Body Composition, Nerve Conduction Velocity, and Cardiac Autonomic Nervous Activity in University Athletes. JEPonline 2019;22(2):78-98. The purpose of this study was to evaluate the effects of an 8-wk resistance training program of the upper and lower limb muscles on body composition, nerve conduction velocity, and cardiac autonomic nervous activity in Burapha University athletes. A randomized pretest-posttest study was conducted in 60 athletes at Burapha University aged 18 to 22 yrs. Subjects were randomized into a control group (CT, n = 20), a high-intensity interval training group (HII, n = 20), and an upper and lower limb resistance training group (ULLR, n = 20). Subjects in the HII and ULLR training groups engaged in exercise training for 30 min·d, 3 d·wk for 8 wks. Before and after the intervention, the following variables were measured in all groups: body composition, nerve conduction velocity, and cardiac autonomic nervous activity. There were significant increases in fat-free mass, protein mass, and water mass in the ULLR training group (P<0.05). In addition, motor conduction amplitude of the median nerve in the ULLR training group was significantly higher than in the CT group (P<0.05). Values of total power and very low frequency power of heart rate variability were significantly higher in the HII training group when compared with the CT group (P<0.05). This study showed that a resistance training program incorporating upper and lower limb muscles improved body composition and motor nerve conduction amplitude. Moreover, HII training improved cardiac autonomic nervous activity.
Plasma Mitochondrial DNA Levels Are Associated With ARDS in Trauma and Sepsis Patients

METHODS: Plasma mtDNA concentrations were measured at ED presentation and approximately 48 h later in separate prospective cohorts of critically ill patients with trauma and sepsis. ARDS was classified according to the Berlin definition. The association of mtDNA with ARDS was tested by using multivariable logistic regression, adjusted for covariates previously shown to contribute to ARDS risk in each population.
SNARF: A Learning-Enhanced Range Filter

We present Sparse Numerical Array-Based Range Filters (SNARF), a learned range filter that efficiently supports range queries for numerical data. SNARF creates a model of the data distribution to map the keys into a bit array which is stored in a compressed form. The model along with the compressed bit array which constitutes SNARF are used to answer membership queries. We evaluate SNARF on multiple synthetic and real-world datasets as a stand-alone filter and by integrating it into RocksDB. For range queries, SNARF provides up to 50x better false positive rate than state-of-the-art range filters, such as SuRF and Rosetta, with the same space usage. We also evaluate SNARF in RocksDB as a filter replacement for filtering requests before they access on-disk data structures. For RocksDB, SNARF can improve the execution time of the system up to 10x compared to SuRF and Rosetta for certain read-only workloads.
CCID_A_359813 997..1019

The number of aesthetic procedures performed worldwide continues to grow together with an increase in the population seeking the restoration or preservation of a youthful appearance. Requests for non-surgical body rejuvenation are increasing. Patients are looking for safe and effective minimally invasive aesthetic procedures. Soft-tissue dermal fillers can meet these expectations. Based on the beneficial outcomes of these treatments in many facial areas, a new trend is developing to target body areas. Different dermal fillers are available and include collagen stimulators initially developed to restore facial volume. Furthermore, they are associated with long-lasting efficiency, a high level of patient satisfaction and a good safety profile, with mainly minor adverse events reported. In appropriate conditions of use, they are now used for body rejuvenation in clinical practice. Their use is expanding and allows addressing various issues including volume loss, skin laxity, cellulite, striae distensae and wrinkles. This review focuses on poly-L-lactic acid (PLLA), used in the first collagen stimulator and one of the most investigated in facial and in off-facial body applications. The available published data, although still limited, are presented by body area, neck and chest, buttocks, abdomen, upper arms, thighs, knees, and hands. Key features of the concerned zones and the main clinical signs affecting the body part as well as the injection modalities are provided along with the aesthetic results. This represents the state of the art on which to base further developments necessary for optimal and safe outcomes of treatment with the PLLA-based collagen stimulators and others in this class for body rejuvenation.