Miracle-dz/UniFAR-FTUs huggingface dataset:
The Stochastic Auxiliary Problem Principle in Banach Spaces: Measurability and Convergence

The stochastic Auxiliary Problem Principle (APP) algorithm is a general Stochastic Approximation (SA) scheme that turns the resolution of an original optimization problem into the iterative resolution of a sequence of auxiliary problems. This framework has been introduced to design decomposition-coordination schemes but also encompasses many well-known SA algorithms such as stochastic gradient descent or stochastic mirror descent. We study the stochastic APP in the case where the iterates lie in a Banach space and we consider an additive error on the computation of the subgradient of the objective. In order to derive convergence results or efficiency estimates for a SA scheme, the iterates must be random variables. This is why we prove the measurability of the iterates of the stochastic APP algorithm. Then, we extend convergence results from the Hilbert space case to the Banach space case. Finally, we derive efficiency estimates for the function values taken at the averaged sequence of iterates or at the last iterate, the latter being obtained by adapting the concept of modified Fej{\'e}r monotonicity to our framework.
Near-Optimal Regret Bounds for Contextual Combinatorial Semi-Bandits with Linear Payoff Functions

The contextual combinatorial semi-bandit problem with linear payoff functions is a decision-making problem in which a learner chooses a set of arms with the feature vectors in each round under given constraints so as to maximize the sum of rewards of arms. Several existing algorithms have regret bounds that are optimal with respect to the number of rounds T. However, there is a gap of Õ(max(√d, √k)) between the current best upper and lower bounds, where d is the dimension of the feature vectors, k is the number of the chosen arms in a round, and Õ(·) ignores the logarithmic factors. The dependence of k and d is of practical importance because k may be larger than T in real-world applications such as recommender systems. In this paper, we fill the gap by improving the upper and lower bounds. More precisely, we show that the C2UCB algorithm proposed by Qin, Chen, and Zhu (2014) has the optimal regret bound Õ(d√kT + dk) for the partition matroid constraints. For general constraints, we propose an algorithm that modifies the reward estimates of arms in the C2UCB algorithm and demonstrate that it enjoys the optimal regret bound for a more general problem that can take into account other objectives simultaneously. We also show that our technique would be applicable to related problems. Numerical experiments support our theoretical results and considerations.
Use of Clove Oil and Eugenol to Anesthetize Fingerling Shabut Barbus grypus

AbstractIn this study, the efficacy of four doses of clove oil and eugenol were compared to sedate fingerling Shabut Barbus grypus to various stages of sedation and recovery. The results from the present study indicated that effective concentrations were at 50 μL/L for eugenol (induction time: 58 ± 8 s; recovery time: 199 ± 15 s [mean ± SD]) and clove oil (induction time: 76 ± 6 s; recovery time: 161 ± 34 s). The induction times decreased significantly with the increasing concentrations of clove oil and eugenol, while recovery times increased with increasing concentrations of anesthetic (P < 0.05). Exposure of fish to 75 or 100 μL/L clove oil or to 50, 75, or 100 μL/L eugenol resulted in mean induction times ≤ 1 min. Fish did not become fully sedated within 3 min when treated with 25 μL/L clove oil. Other concentrations of both anesthetics, fish reached to full induction at ≤ 3 min and recovered from anesthesia ≤ 5 min. Our results showed the clove oil and eugenol are effective anesthetics for fingerling .
Chromium, Copper, and Arsenic Concentrations in Soil Underneath CCA-Treated Wood Structures

Soils below nine structures (decks and foot bridges) in Florida were examined to evaluate potential impacts from chromated copper arsenate (CCA), a common wood preservative. Eight of the nine structures were confirmed to have been treated with CCA. Soils collected were evaluated for arsenic, chromium, and copper concentrations as well as pH, volatile solids content and particle size distribution. Two types of soil samples were collected: a soil core and surface soil samples (upper 2.5 cm). One soil core was collected from below each deck and one control core was collected from an area removed from one of the structures. Eight or nine surface soil samples were collected in a grid-like fashion from beneath each structure. Equal numbers of surface control samples were collected from areas away from the structures. Metal concentrations were elevated in both the soil cores and surface samples collected from below the CCA-treated structures. Core samples showed elevated concentrations of metals at depths up to 20 cm. The arithmetic mean concentrations of arsenic, chromium, and copper in the 65 surface soil samples collected from below CCA-treated structures were 28.5 mg/kg, 31.1 mg/kg, and 37.2 mg/kg, respectively, whereas the mean concentrations of arsenic, chromium, and copper in the control samples were 1.34 mg/kg, 8.62 mg/kg, and 6.05 mg/kg, respectively. Arsenic concentrations exceeded Florida's risk-based soil cleanup target level (SCTL) for residential settings in all 65 surface soil samples. The industrial setting SCTL was exceeded in 62 of the 65 samples.
Successive occurrences of quasi-circular ribbon flares in a fan-spine-like configuration involving hyperbolic flux tube

We present a comprehensive analysis of the formation and evolution of a fan-spine-like configuration that developed over a complex photospheric configuration where dispersed negative polarity regions were surrounded by positive polarity regions. This unique photospheric configuration, analogous to the geological “atoll" shape, hosted four homologous flares within its boundary. Computation of the degree of squashing factor (Q) maps clearly revealed an elongated region of high Q-values between the inner and outer spine-like lines, implying the presence of an hyperbolic flux tube (HFT). The coronal region associated with the photospheric atoll configuration was distinctly identified in the form of a diffused dome-shaped bright structure directly observed in EUV images. A filament channel resided near the boundary of the atoll region. The activation and eruption of flux ropes from the filament channel led to the onset of four eruptive homologous quasi-circular ribbon flares within an interval of≈11 hours. During the interval of the four flares, we observed continuous decay and cancellation of negative polarity flux within the atoll region. Accordingly, the apparent length of the HFT gradually reduced to a null-point-like configuration before the fourth flare. Prior to each flare, we observed localised brightening beneath the filaments which, together with flux cancellation, provided support for the tether-cutting model of solar eruption. The analysis of magnetic decay index revealed favourable conditions for the eruption, once the pre-activated flux ropes attained the critical heights for torus instability.
Discriminant groups of wild cyclic quotient singularities

Let p be prime. We describe explicitly the resolution of singularities of several families of wild Z/pZ-quotient singularities in dimension two, including families that generalize the quotient singularities of type E_6, E_7, and E_8 from p=2 to arbitrary characteristics. We prove that for odd primes, any power of p can appear as the determinant of the intersection matrix of a wild Z/pZ-quotient singularity. We also provide evidence towards the conjecture that in this situation one may choose the wild action to be ramified precisely at the origin.
Características físico-químicas e sensoriais do queijo Minas artesanal produzido na região do Serro, Minas Gerais

The objective of this study was characterize the sensorial and physico-chemical properties of the artisanal Minas cheese produced in the region of Serro, Minas Gerais. Twenty samples were analysed. For the sensory analysis, it has been used the nine points hedonic verbal scale acceptance test. The result was an average score of 6.03±2.04, wich was attributed by thirty judges, and so that it has been defined as "I like the product slightly". The physico-chemical parameters average values found were: fat content-29.22g/100g; pH-4.98; moisture content-50.84g/100g; ashes-3.79g/100g; chlorides-4.39g/100g; lactose-0.55g/100g; titrable acidity-0.28 (g/100g of lactic acid); non-proteic nitrogen-0.27g/100g; total nitrogen-2.94g/100g; true protein-17.06g/100g; depth of proteolysis-9.18; diameter-13.60cm; height-5.58cm; weight-927.30g. There was no significant difference (p>0,05) between the great and small producers, considering those physico-chemical and sensory evaluation. These cheeses are not adjusted to the following denomination "medium moisture content" (between 36.0 and 45.9g/100g) defined for the Serro's Minas cheese by the Brazilian Department of Agriculture and Supplying in the Resolution number 7 (28 November 2000). Thus, Minas cheese of Serro is characterized as a high moisture content cheese (between 46.0 and 54.9g/100g).
Knockout of calpain‐1 protects against high‐fat diet‐induced liver dysfunction in mouse through inhibiting oxidative stress and inflammation

Abstract The present study was designed to investigate the significance of calpain‐1 in the high‐fat diet (HFD)‐induced liver dysfunction and to explore the possible mechanism. C57 mice and calpain‐1 knockout (KO) mice were fed with standard diet (SD) or HFD, respectively, for 16 weeks. The activities of calpain, aspartate aminotransferase (AST), alanine aminotransferase (ALT), and superoxide dismutase (SOD) in serum and/or liver of mouse were measured. Lipid profiles in the serum and liver were examined. Contents of oxidized low‐density lipoprotein (oxLDL), malondialdehyde (MDA), tumor necrosis factor (TNF‐α), and interleukin‐6 (IL‐6) in serum or/and liver were detected. The results showed that compared with C57 mice fed with SD, HFD‐fed C57 mice showed the increased activities of AST and ALT in the serum, which was decreased in calpain‐1 KO mice fed with HFD. In addition, knockout of calpain‐1 decreased the contents of oxLDL, MDA, TNF‐α, and IL‐6, while increased SOD activity, in serum and/or liver. However, knockout of calpain‐1 had no effects on lipid profiles in both serum and liver. When fed with SD, all these parameters of C57 and calpain‐1 KO mice were comparable except for decreased calpain activity in the liver of calpain‐1 KO mice. The results suggested that knockout of calpain‐1 protects against HFD‐induced liver dysfunction through inhibiting oxidative stress and inflammation.
Measuring particle concentration of multimodal synthetic reference materials and extracellular vesicles with orthogonal techniques: Who is up to the challenge?

Abstract The measurement of physicochemical properties of polydisperse complex biological samples, for example, extracellular vesicles, is critical to assess their quality, for example, resulting from their production and isolation methods. The community is gradually becoming aware of the need to combine multiple orthogonal techniques to perform a robust characterization of complex biological samples. Three pillars of critical quality attribute characterization of EVs are sizing, concentration measurement and phenotyping. The repeatable measurement of vesicle concentration is one of the key‐challenges that requires further efforts, in order to obtain comparable results by using different techniques and assure reproducibility. In this study, the performance of measuring the concentration of particles in the size range of 50–300 nm with complementary techniques is thoroughly investigated in a step‐by step approach of incremental complexity. The six applied techniques include multi‐angle dynamic light scattering (MADLS), asymmetric flow field flow fractionation coupled with multi‐angle light scattering (AF4‐MALS), centrifugal liquid sedimentation (CLS), nanoparticle tracking analysis (NTA), tunable resistive pulse sensing (TRPS), and high‐sensitivity nano flow cytometry (nFCM). To achieve comparability, monomodal samples and complex polystyrene mixtures were used as particles of metrological interest, in order to check the suitability of each technique in the size and concentration range of interest, and to develop reliable post‐processing data protocols for the analysis. Subsequent complexity was introduced by testing liposomes as validation of the developed approaches with a known sample of physicochemical properties closer to EVs. Finally, the vesicles in EV containing plasma samples were analysed with all the tested techniques. The results presented here aim to shed some light into the requirements for the complex characterization of biological samples, as this is a critical need for quality assurance by the EV and regulatory community. Such efforts go with the view to contribute to both, set‐up reproducible and reliable characterization protocols, and comply with the Minimal Information for Studies of Extracellular Vesicles (MISEV) requirements.
The Influence of Polyampholytes on the Phase Behavior of Microemulsion Used as Template for the Nanoparticle Formation

A series of hydrophobically modified polyampholytes has been synthesized by the copolymerization of the cationic monomer (N,N′‐diallyl‐N,N′‐dimethylammonium chloride) and the anionic monomers maleamic acid or butylmaleamic acid, and their influence on the inverse micellar region of the quaternary system sodium dodecylsulfate/toluene‐pentanol (1:1)/water has been investigated. The polymers increase the water solubilization capacity of the microemulsion at a polymer concentration ≥5%. However, the polyampholyte‐modified inverse microemulsions show a temperature dependent behavior, by the formation at 40°C of a narrow bicontinuous channel between the L2 (w/o) and the L1 (o/w) microemulsion phases. In this case, hydrophobic interactions between the surfactant alkyl tails and the hydrophobic side chains of the copolymer play an important role, too. The reverse microemulsion droplets were used as a template for the synthesis of BaSO4 nanoparticles. The polymers, which are involved in the redispersion process, influence the size and the stability of the nanoparticles formed by preventing their aggregation. Finally, monodisperse BaSO4 nanoparticles with an average size of 5 nm, thus, can be recovered and characterized by dynamic light scattering, zeta potential measurements, and transmission electron microscopy.
Application of PCR for Specific Diagnosis of Leptospirosis in Humans in Ukraine

Abstract Leptospirosis remains one of the most widespread zoonotic diseases in the world and Ukraine, in particular. Ukrainian clinicians have been faced with early detection of the disease due to the availability of only a serological method for routine diagnostics in Ukraine, namely the microscopic agglutination test (MAT). This paper demonstrates the first results of the complex application of MAT and polymerase chain reaction (PCR) for routine verification of leptospirosis, which were first applied simultaneously in Lviv Oblast of Ukraine in 2016. We examined the sera of 150 patients clinically suspected of leptospirosis, 31 of whom were treated at the Lviv Oblast Clinical Hospital for Infectious Diseases (LOCHID). The application of PCR during the first seven days of the disease allowed increasing the share of confirmed leptospirosis cases by 16,1% in patients that were treated in LOCHID during 2016–2017.
Biofilm-Forming Ability and Effect of Sanitation Agents on Biofilm-Control of Thermophile Geobacillus sp. D413 and Geobacillus toebii E134

Abstract Geobacillus sp. D413 and Geobacillus toebii E134 are aerobic, non-pathogenic, endospore-forming, obligately thermophilic bacilli. Gram-positive thermophilic bacilli can produce heat-resistant spores. The bacteria are indicator organisms for assessing the manufacturing process’s hygiene and are capable of forming biofilms on surfaces used in industrial sectors. The present study aimed to determine the biofilm-forming properties of Geobacillus isolates and how to eliminate this formation with sanitation agents. According to the results, extracellular DNA (eDNA) was interestingly not affected by the DNase I, RNase A, and proteinase K. However, the genomic DNA (gDNA) was degraded by only DNase I. It seemed that the eDNA had resistance to DNase I when purified. It is considered that the enzymes could not reach the target eDNA. Moreover, the eDNA resistance may result from the conserved folded structure of eDNA after purification. Another assumption is that the eDNA might be protected by other extracellular polymeric substances (EPS) and/or extracellular membrane vesicles (EVs) structures. On the contrary, DNase I reduced unpurified eDNA (mature biofilms). Biofilm formation on surfaces used in industrial areas was investigated in this work: the D413 and E134 isolates adhered to all surfaces. Various sanitation agents could control biofilms of Geobacillus isolates. The best results were provided by nisin for D413 (80%) and α-amylase for E134 (98%). This paper suggests that sanitation agents could be a solution to control biofilm structures of thermophilic bacilli.
Layered perovskites as promising cathodes for intermediate temperature solid oxide fuel cells

The suitability of GdBaCo2O5+δ as a cathode material for intermediate temperature solid oxide fuel cells has been evaluated. The 18O/16O isotope exchange depth profile (IEDP) method has been used to obtain the oxygen surface exchange and oxygen tracer diffusion coefficients yielding optimum values for applicability in fuel cells (k* = 2.8 × 10−7 cm s−1 and D* = 4.8 × 10−10 cm2 s−1 at 575 °C) especially in terms of low activation energies (EAk = 0.81(4) and EAD = 0.60(4) eV). The same material has been characterized electrically as a part of a symmetrical electrochemical system (GdBaCo2O5+δ/Ce0.9Gd0.1O2−x/GdBaCo2O5+δ), by means of impedance spectroscopy measurements, corroborating an excellent performance in the classical intermediate temperature range for solid oxide fuel cells (500–700 °C). An area specific resistance (electrode–electrolyte interface) of 0.25 Ω cm2 at 625 °C was achieved for a cell processing temperature of 975 °C. Finally, layered perovskites are presented as a promising new family of materials for cathode use in solid oxide fuel cells at low temperatures.
Thermal Degradation of Linalool-Chemotype Cinnamomum osmophloeum Leaf Essential Oil and Its Stabilization by Microencapsulation with β-Cyclodextrin

The thermal degradation of linalool-chemotype Cinnamomum osmophloeum leaf essential oil and the stability effect of microencapsulation of leaf essential oil with β-cyclodextrin were studied. After thermal degradation of linalool-chemotype leaf essential oil, degraded compounds including β-myrcene, cis-ocimene and trans-ocimene, were formed through the dehydroxylation of linalool; and ene cyclization also occurs to linalool and its dehydroxylated products to form the compounds such as limonene, terpinolene and α-terpinene. The optimal microencapsulation conditions of leaf essential oil microcapsules were at a leaf essential oil to the β-cyclodextrin ratio of 15:85 and with a solvent ratio (ethanol to water) of 1:5. The maximum yield of leaf essential oil microencapsulated with β-cyclodextrin was 96.5%. According to results from the accelerated dry-heat aging test, β-cyclodextrin was fairly stable at 105 °C, and microencapsulation with β-cyclodextrin can efficiently slow down the emission of linalool-chemotype C. osmophloeum leaf essential oil.
Determination of pharmaceuticals from various therapeutic classes in dewatered sludge by pressurized liquid extraction and high performance liquid chromatography and tandem mass spectrometry (HPLC-MS/MS)

Pharmaceuticals are released to the environment after human and animal consumption, which partly comes from accumulation in sewage sludge during wastewater treatment. This paper developed a method for the determination of N,N-diethyl-meta-toluamide (DEET) and 14 pharmaceuticals belonging to multiple therapeutic classes such as antibiotic, anti-inflammatory, antilipidemic, anti-hypertensive, and anticonvulsant in dewatered sludge. Pressurized liquid extraction using methanol/McIlvaine buffer (volume ratio, 1 : 1), associated with HPLC-MS/MS was proven to be effective for extraction and quantification of pharmaceuticals and DEET in dewatered sludge. Optimization procedures, including extraction method, extraction solvents and clean-up treatment, were carried out by simulating naturally aged samples to provide a more realistic extraction than previous methods, which were often done by spiking the standard solution before extraction without any aging procedures. The internal standard quantification method using six isotopically labelled compounds was applied to improve the poor absolute recoveries induced by severe matrix effects to obtain better relative recoveries (70–120%). Good relative standard deviations (lower than 19.0% for 7 repeats) and the limit of quantification (0.6–19.4 µg/kg) indicated that the developed method was reliable and sensitive to extract and quantify the studied pharmaceuticals in dewatered sludge. For samples collected from eight sewage treatment plants in Beijing, China, it was found that trimethoprim, caffeine, ketoprofen and ibuprofen were the most prominent contaminants, with the median concentrations reaching 97.6, 179.4, 268.0 and 153.0 µg/kg, respectively. The level of ketoprofen, ibuprofen, mefenamic acid, cabamazepine and diclofenac were similar to results reported from Spain, whilst the levels of other compounds were similar to those found in Germany, Canada and the US.
Mitochondrial dysfunction, mitophagy, and role of dynamin‐related protein 1 in Alzheimer's disease

Alzheimer's disease (AD) is the most common type of dementia and progressive neurodegenerative disease. The presence of β‐amyloid (Aβ) plaques and phosphorylated Tau tangles are considered to be the two main hallmarks of AD. Recent findings have shown that different changes in the structure and dynamics of mitochondria play an important role in AD pathology progression. Mitochondrial changes in AD are expressed as enhanced mitochondrial fragmentation, altered mitochondrial dynamics, and changes in the expression of mitochondrial biogenesis genes in vitro and in vivo models. Therefore, targeting mitochondria and associated mitochondrial proteins seems to be a promising alternative instead of targeting Aβ and Tau in the prevention of Alzheimer's disease. The dynamin‐related protein (Drp1) is one such protein that plays an important role in the regulation of mitochondrial division and maintenance of mitochondrial structures. Few researchers have shown that inhibition of Drp1 GTPase activity in neuronal cells rescues excessive mitochondrial fragmentation. In addition, the growing evidence revealed that Drp1 can interact with both Aβ and Tau protein in human brain tissues and mouse models. In this review, we would like to update existing knowledge about various changes in and around mitochondria related to the pathogenesis of Alzheimer's disease, with particular emphasis on mitophagy and autophagy.