Miracle-dz/UniFAR-FTUs huggingface dataset:
Clinical Spectrum and Outcomes of Cryptogenic Klebsiella pneumoniae Liver Abscess in the Americas: A Scoping Review

(1) Background: Cryptogenic Klebsiella pneumoniae liver abscesses are an invasive infection with or without extra hepatic involvement in the absence of hepatobiliary disease or abdominal malignancy. Most of the evidence has emanated from reports from Asia, and previous studies in the Americas have limited clinical characterization. (2) Methods: To understand this syndrome’s characteristics on our continent, we conducted a scoping review to identify adult cases of idiopathic, community-acquired monomicrobial K. pneumoniae liver abscess in the Americas. (3) Results: We identified 144 cases spanning 1978–2022. Most cases were reported in males that had traveled or migrated from Southeast or East Asia with diabetes mellitus. Extrahepatic involvement and bacteremia were common, including seeding to the lungs, ocular structures, and central nervous system. Although limited by sample size, the most commonly reported genes were magA or rmpA. Concomitant percutaneous drainage and third generation cephalosporins (alone or in combination with other antibiotics) were frequently used, yet pooled fatality occurred in 9% of the reported cases. (4) Conclusions: The features of cryptogenic K. pneumoniae liver abscess in the Americas mirror those described in Asia, confirming its global dissemination. This condition is increasingly being reported in our continent and carries significant clinical impact due to its systemic invasiveness.
Pathways between Risk/Protective Factors and Maternal Postnatal Depressive Symptoms: The ELFE Cohort

Objective: The risk factors for postnatal depressive symptoms (PNDS) are numerous, but little is known about the protective factors or the interactions between different exposures. The present study explored the pathways between maternal, infant and parenthood vulnerabilities or risk/protective factors and PNDS at 2 months postpartum (PP) in a large sample of women from the general population. Methods: We used data from the French ELFE cohort, a nationally representative cohort of children followed-up from birth. The available information about vulnerabilities or risk/protective factors for PNDS was collected during the maternity ward stay (mother or medical records) and at 2 months PP (mother by phone). PNDS were evaluated with the Edinburgh Postnatal Depression Scale (EPDS) at 2 months. A measurement model was built based on the psychosocial model for PNDS of Milgrom and colleagues using exploratory factor analysis. The Structural Equation Model was used to investigate the pathways between vulnerability, risk/protective factors and PNDS at 2 months PP. Results: In the study sample (n = 11,583), a lack of a partner’s perceived antenatal emotional support, consultation with a mental health specialist before pregnancy, family financial difficulties, prenatal psychological distress and a difficult pregnancy experience were directly associated with the severity of maternal PNDS at 2 months PP, as well as lack of perceived postnatal support. Family financial difficulties and consultation with a mental health specialist before pregnancy were also indirectly associated with the intensity of PNDS through a lack of perceived antenatal emotional support, a difficult pregnancy experience, prenatal psychological distress and a lack of perceived postnatal support. Regarding infant and parenthood characteristics, infant self-regulation difficulties, maternal difficulty in understanding infant crying and infant hospitalisation were directly associated with PNDS severity at 2 months PP, while maternal difficulty in understanding an infant’s cries was also indirectly associated with infant self-regulation difficulties. Conclusions: Perinatal professional support should begin antenatally and target the couple’s prenatal functioning, with particular attention to women presenting a history of psychiatric disorders, especially those of low socioeconomic status. After delivery, addressing infant and parenthood characteristics is also recommended.
NEW INFINITE FAMILIES OF CONGRUENCES MODULO 4 AND 8 FOR 1-SHELL TOTALLY SYMMETRIC PLANE PARTITIONS

Abstract In 2012, Blecher [‘Geometry for totally symmetric plane partitions (TSPPs) with self-conjugate main diagonal’, Util. Math. 88 (2012), 223–235] introduced a special class of totally symmetric plane partitions, called $\def \xmlpi #1{}\def \mathsfbi #1{\boldsymbol {\mathsf {#1}}}\let \le =\leqslant \let \leq =\leqslant \let \ge =\geqslant \let \geq =\geqslant \def \Pr {\mathit {Pr}}\def \Fr {\mathit {Fr}}\def \Rey {\mathit {Re}}1$-shell totally symmetric plane partitions. Let $f(n)$ denote the number of $1$-shell totally symmetric plane partitions of weight $n$. More recently, Hirschhorn and Sellers [‘Arithmetic properties of 1-shell totally symmetric plane partitions’, Bull. Aust. Math. Soc. to appear. Published online 27 September 2013] discovered a number of arithmetic properties satisfied by $f(n)$. In this paper, employing some results due to Cui and Gu [‘Arithmetic properties of $l$-regular partitions’, Adv. Appl. Math. 51 (2013), 507–523], and Hirschhorn and Sellers, we prove several new infinite families of congruences modulo 4 and 8 for $1$-shell totally symmetric plane partitions. For example, we find that, for $n\geq 0$ and $\alpha \geq 1$, $$\begin{equation*} f(8 \times 5^{2\alpha } n+39\times 5^{2\alpha -1})\equiv 0 \pmod 8. \end{equation*}$$
Towards molecular-scale kinetic Monte Carlo simulation of pattern formation in photoresist materials for EUV nanolithography

Modelling the pattern formation process in photoresist materials for extreme ultraviolet (EUV) lithography in a stochastic and mechanistic manner, with molecular-scale resolution, should enable predicting the effect of variations of material parameters and process conditions, leading to insights into the ultimate resolution limits. In this work, we present the results of the first steps toward that goal. We describe the physics of the development with time of cascades of electrons and holes, created by the stochastic absorption of 92 eV photons, using a kinetic Monte Carlo model with molecular resolution. The thin film material is modelled assuming a cubic array of lattice sites, at a distance that is consistent with the molecular density of the photoresist material that is considered. The simulation of the cascading process is based on the experimental optical energy loss function, extended to include also excitations with momentum transfer. The method allows for including the Coulomb interactions between charges. In contrast to earlier work, within which the high-energy electrons move ballistically until scattering takes place, the trajectories are in our model formed by stochastically determined interconnected molecular sites. In future extensions of the model, this approach will facilitate including in a natural way a transition from delocalized electron transport at high energies to hopping transport of localized electrons at low energies. The simulations are used to study the sensitivity of the average number of degradations per absorbed photon and the average electron blur length on the rates of elastic scattering and of molecular degradation, and on the energy that is lost upon a molecular degradation process.
TP-GAN: Simple Adversarial Network With Additional Player for Dense Depth Image Estimation

We present a simple yet robust monocular depth estimation technique by synthesizing a depth map image from a single RGB input image using the advantage of generative adversarial networks (GAN). We employ an additional sub-model termed refiner to extract local depth features, then combine it with the global scene information from the generator to improve the GAN’s performance compared to the standard GAN architectural scheme. Notably, the generator is the first player to learn to synthesize depth images. The second player, the discriminator, classifies the generated depth. In the meantime, the third player, the refiner, enhances the final reconstructed depth. Complementing the GAN model, we apply a conditional generative network (cGAN) to lead the generator in mapping the input image to the respective depth representation. We further incorporate a structured similarity (SSIM) as our loss function for the generator and refiner in GAN training. Through extensive experiment validation, we confirmed the performance of our strategy on the publicly indoor NYU Depth v2 and KITTI outdoor data. Experiment results on the NYU depth v2 dataset show that our proposed approach achieves the best performance by 96.0% on threshold accuracy ( $\delta < 1.25^{2}$ ) and the second-best accuracy on all thresholds on the KITTI dataset. We discovered that our proposed method compares favorably to numerous existing monocular depth estimation strategies and demonstrates a considerable improvement in the accuracy of image depth estimation despite its simple network architecture.
Molecular Characterization of Leptospira Species Detected in the Kidneys of Slaughtered Livestock in Abattoirs in Gauteng Province, South Africa

Leptospira was investigated in kidneys (n = 305) from slaughtered livestock in the Gauteng Province abattoirs, South Africa, using a culture medium to isolate Leptospira, followed by the LipL32 qPCR to detect Leptospira DNA. The SecY gene region was amplified, sequenced, and analyzed for LipL32 qPCR-positive samples or Leptospira isolates. The overall frequency of isolation of Leptospira spp. was 3.9% (12/305), comprising 4.8% (9/186), 4.1% (3/74), and 0% (0/45) from cattle, pigs, and sheep, respectively (p > 0.05). However, with LipL32 qPCR, the overall frequency of Leptospira DNA was 27.5%, consisting of 26.9%, 20.3%, and 42.2% for cattle, pigs, and sheep, respectively (p = 0.03). Based on 22 SecY sequences, the phylogenetic tree identified the L. interrogans cluster with serovar Icterohaemorrhagiae and the L. borgpetersenii cluster with serovar Hardjo bovis strain Lely 607. This study is the first molecular characterization of Leptospira spp. from livestock in South Africa. The reference laboratory uses an eight-serovar microscopic agglutination test panel for leptospirosis diagnosis, of which L. borgpetersenii serovar Hardjo bovis is not part. Our data show that pathogenic L. interrogans and L. borgpetersenii are circulating in the livestock population. Diagnostic use of molecular methods will eliminate or reduce the under-reporting of leptospirosis in livestock, particularly sheep, in South Africa.
A Virtual Reality Exergame: Clinician-Guided Breathing and Relaxation for Children with Muscular Dystrophy

This study introduces a VR-based breathing and relaxation exergame tailored for individuals with Duchenne muscular dystrophy (DMD). DMD is a rare neuromuscular disease that leads to respiratory muscle dysfunction with anxiety being a common comorbidity. Clinical management requires frequent visits to rare disease specialists to manage symptom progression. Limited availability and/or proximity of rare disease experts present challenges to care and can lead to missed care opportunities and reduced quality of life. We propose a breathing and relaxation exergame with remote telehealth applicability that incorporates shared patient-clinician VR interaction, and physiological sensors that provide both real-time feedback to the patient and health analytics for the clinician. The game focuses on two key aspects of DMD clinical care that can be mediated through control of breathing: relaxation/mindfulness training and respiratory muscle exercise. The system was evaluated among 13 individuals, including 4 participants with DMD. Feedback surveys, interviews, and focus group discussions with participants, accompanying family members, and clinicians demonstrated the feasibility of this VR tool for telehealth or as part of a home exercise program.
Donkey Colostrum and Milk: How Dietary Probiotics Can Affect Metabolomic Profile, Alkaline Sphingomyelinase and Alkaline Phosphatase Activity

Positive results on animal health, feed efficiency, and milk’s nutritional content have been obtained after oral administration of probiotics. The aim of the present study was therefore to evaluate the effect of dietary supplementation with high numbers of multispecies probiotic formulations on the milk metabolomic profiles of alkaline sphingomyelinase (alk-SMase) and alkaline phosphatase (ALP) in donkeys. Twenty animals were randomly allocated to receive either a normal diet (group B) or a supplemented diet (group A). Colostrum and milk samples were obtained within 48 h, at 15 days (supplementation start), and at 45 days after parturition. Different metabolomic profiles were observed between colostrum and milk, as were the concentrations of 12 metabolites that changed following 30 days of probiotic supplementation. Alk-SMase activity was found to be higher in donkey colostrum (vs. milk at 15 days); this enzyme, together with ALP, increased in milk after 30 days of probiotic supplementation. The results of the present study provide new insight into the complex changes in donkey colostrum and milk composition in the first 45 days of lactation and how the milk metabolome can be modulated by probiotic supplementation.
Long-Term Effects of Severe Burns on the Kidneys: Research Advances and Potential Therapeutic Approaches

Abstract Burns are a seriously underestimated form of trauma that not only damage the skin system but also cause various complications, such as acute kidney injury (AKI). Recent clinical studies have shown that the proportion of chronic kidney diseases (CKD) in burn patients after discharge is significantly higher than that in the general population, but the mechanism behind this is controversial. The traditional view is that CKD is associated with hypoperfusion, AKI, sepsis, and drugs administered in the early stages of burns. However, recent studies have shown that burns can cause long-term immune dysfunction, which is a high-risk factor for CKD. This suggests that burns affect the kidneys more than previously recognized. In other words, severe burns are not only an acute injury but also a chronic disease. Neglecting to study long-term kidney function in burn patients also results in a lack of preventive and therapeutic methods being developed. Furthermore, stem cells and their exosomes have shown excellent comprehensive therapeutic properties in the prevention and treatment of CKD, making them increasingly the focus of research attention. Their engineering strategy further improved the therapeutic performance. This review will focus on the research advances in burns on the development of CKD, illustrating the possible mechanism of burn-induced CKD and introducing potential biological treatment options and their engineering strategies.
Recurrent/Subsequent Stroke and Associated Outcomes in Geriatric Patients with OSA and Prior Stroke Events: A Retrospective Study Using the 2019 National Inpatient Sample

Abstract Background: Obstructive sleep apnea (OSA) increases the risk of stroke and cardiovascular diseases. However, its impact on geriatric patients with a prior history of stroke/transient ischemic attack (TIA) has not been adequately studied. Methods: We utilized the 2019 National Inpatient Sample in the US to identify geriatric patients with OSA (G-OSA) who had a prior history of stroke/TIA. We then compared subsequent stroke (SS) rates among sex and race subgroups. We also compared the demographics and comorbidities of SS+ and SS− groups and utilized logistic regression models to assess outcomes. Results: Out of 133,545 G-OSA patients admitted with a prior history of stroke/TIA, 4.9% (6520) had SS. Males had a higher prevalence of SS, while Asian-Pacific Islanders and Native Americans had the highest prevalence of SS, followed by Whites, Blacks, and Hispanics. The SS+ group had higher all-cause in-hospital mortality rates, with Hispanics showing the highest rate compared to Whites and Blacks (10.6% vs. 4.9% vs. 4.4%, p < 0.001), respectively. Adjusted analysis for covariates showed that complicated and uncomplicated hypertension (aOR 2.17 [95% CI 1.78–2.64]; 3.18 [95% CI 2.58–3.92]), diabetes with chronic complications (aOR 1.28 [95% CI 1.08–1.51]), hyperlipidemia (aOR 1.24 [95% CI 1.08–1.43]), and thyroid disorders (aOR 1.69 [95% CI 1.14–2.49]) were independent predictors of SS. The SS+ group had fewer routine discharges and higher healthcare costs. Conclusions: Our study shows that about 5% of G-OSA patients with a prior history of stroke/TIA are at risk of hospitalization due to SS, which is associated with higher mortality and healthcare utilization. Complicated and uncomplicated hypertension, diabetes with chronic complications, hyperlipidemia, thyroid disorders, and admission to rural hospitals predict subsequent stroke.
Time‐dependent coupled‐cluster theory

Recent years have witnessed an increasing interest in time‐dependent coupled‐cluster (TDCC) theory for simulating laser‐driven electronic dynamics in atoms and molecules, and for simulating molecular vibrational dynamics. Starting from the time‐dependent bivariational principle, we review different flavors of single‐reference TDCC theory with either orthonormal static, orthonormal time‐dependent, or biorthonormal time‐dependent spin orbitals. The time‐dependent extension of equation‐of‐motion coupled‐cluster theory is also discussed, along with the applications of TDCC methods to the calculation of linear absorption spectra, linear and low‐order nonlinear response functions, highly nonlinear high harmonic generation spectra and ionization dynamics. In addition, the role of TDCC theory in finite‐temperature many‐body quantum mechanics is briefly described along with a few other application areas.
Microphysics of Venusian Clouds in Rising Tropical Air

Abstract As the global distribution of Venusian H2SO4–H2O clouds is strongly related to the global circulation of H2SO4 governed by wind transport and sedimentation of droplets, the circulation of H2SO4 in the Tropics was studied by simultaneously solving advection and cloud microphysics equations using a one-dimensional model that includes a weak upwelling representing the rising branch of Hadley circulation near the equator. H2SO4 vapor in the upper cloud region is supplied by photochemical production and condenses into cloud droplets that are removed from the tropical atmosphere by Hadley circulation, whereas in middle and lower cloud regions, dynamical processes supply H2SO4 vapor from below such that resultant droplets are large and fall against the upwelling. The combination of the mean upward advection of vapor and the sedimentation of droplets leads to accumulation of H2SO4 and H2O vapor near the cloud base: an observed phenomenon. A separate model run was performed to investigate the effect of tr.
Some Aspects of the Physiology of the Nyctotherus velox, a Commensal Ciliated Protozoon Taken from the Hindgut of the Tropical Millipede Archispirostreptus gigas

In this paper, the growth requirements, fermentation pattern, and hydrolytic enzymatic activities of anaerobic ciliates collected from the hindgut of the African tropical millipede Archispirostreptus gigas are described. Single-cell molecular analysis showed that ciliates from the millipede hindgut could be assigned to the Nyctotherus velox and a new species named N. archispirostreptae n. sp. The ciliate N. velox can grow in vitro with unspecified prokaryotic populations and various plant polysaccharides (rice starch-RS, xylan, crystalline cellulose20-CC, carboxymethylcellulose-CMC, and inulin) or without polysaccharides (NoPOS) in complex reduced medium with soluble supplements (peptone, glucose, and vitamins). Specific catalytic activity (nkat/g of protein) of α amylase of 300, xylanase of 290, carboxymethylcellulase of 190, and inulinase of 170 was present in the crude protein extract of N. velox. The highest in vitro dry matter digestibility was observed in RS and inulin after 96 h of fermentation. The highest methane concentration was observed in xylan and inulin substrates. The highest short-chain fatty acid concentration was observed in RS, inulin, and xylan. In contrast, the highest ammonia concentration was observed in NoPOS, CMC, and CC. The results indicate that starch is the preferred substrate of the N. velox. Hydrolytic enzyme activities of N. velox showed that the ciliates contribute to the fermentation of plant polysaccharides in the gut of millipedes.
Seamount Subduction and Megathrust Seismicity: The Interplay Between Geometry and Friction

Subducting seamounts are recognized as one of the key features influencing megathrust earthquakes. However, whether they trigger or arrest ruptures remains debated. Here, we use analog models to study the influence of a single seamount on megathrust earthquakes, separating the effect of topography from that of friction. Four different model configurations have been developed (i.e., flat interface, high and low friction seamount, low friction patch). In our models, the seamount reduces recurrence time, interseismic coupling, and fault strength, suggesting that it acts as a barrier: 80% of the ruptures concentrate in flat regions that surround the seamount and only smaller magnitude earthquakes nucleate above it. The low‐friction zone, which mimics the fluid accumulation or the establishment of fracture systems in natural cases, seems to be the most efficient in arresting rupture propagation in our experimental setting.
An In Vitro and In Vivo Assessment of Antitumor Activity of Extracts Derived from Three Well-Known Plant Species

One of the objectives of this study consists of the assessment of the antitumor activity of several extracts from three selected plant species: Xanthium spinosum L. , Trifolium pratense L. , and Coffea arabica L. and also a comparative study of this biological activity, with the aim of establishing a superior herbal extract for antitumor benefits. The phytochemical profile of the extracts was established by HPLC-MS analysis. Further, the selected extracts were screened in vitro for their antitumor activity and antioxidant potential on two cancer cell lines: A549—human lung adenocarcinoma and T47D-KBluc—human breast carcinoma and on normal cells. One extract per plant was selected for in vivo assessment of antitumor activity in an Ehrlich ascites mouse model. The extracts presented high content of antitumor compounds such as caffeoylquinic acids in the case of X. spinosum L. (7.22 µg/mL—xanthatin, 4.611 µg/mL—4-O-caffeoylquinic acid) and green coffee beans (10.008 µg/mL—cafestol, 265.507 µg/mL—4-O-caffeoylquinic acid), as well as isoflavones in the case of T. pratense L. (6806.60 ng/mL—ononin, 102.78 µg/mL—biochanin A). Concerning the in vitro results, the X. spinosum L. extracts presented the strongest anticancerous and antioxidant effects. In vivo, ascites cell viability decreased after T. pratense L. and green coffee bean extracts administration, whereas the oxidative stress reduction potential was important in tumor samples after T. pratense L. Cell viability was also decreased after administration of cyclophosphamide associated with X. spinosum L. and T. pratense L. extracts, respectively. These results suggested that T. pratense L. or X. spinosum L. extracts in combination with chemotherapy can induce lipid peroxidation in tumor cells and decrease the tumor viability especially, T. pratense L. extract.