Miracle-dz/UniFAR-FTUs huggingface dataset:
A Stratigraphic Index Of Dinoflagellate Cysts

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The Heat and Momentum Budgets of Titan's Middle Atmosphere

The thermal and dynamical structure of Titan's middle atmosphere (the stratosphere and mesosphere) has been observed to evolve over seasonal timescales. Measurements from the Composite Infrared Spectrometer on the Cassini spacecraft indicated the presence of a westerly jet with the strongest winds exceeding 200 m s−1 near the autumn and spring poles. The strength of the winds varied substantially with latitude and altitude, and weakened throughout most of winter. The strong winds also served to trap short‐lived trace molecules near the winter pole, leading to a chemically enriched environment. Here, to better understand the evolution of the middle atmosphere jet, we quantify the heat and zonal momentum budgets in Titan's stratosphere and mesosphere over the course of a Titan year using a three‐dimensional general circulation model. We confirm that the dominant heating balance is between the net radiative and adiabatic heating rates, and also show that the convergence of sensible heat by the atmospheric flow is important at low stratospheric altitudes above the winter pole. We show that the polar jet is maintained by the convergence of zonal momentum by the mean meridional flow, while the low‐latitude winds are maintained by an up‐gradient transport of momentum by eddies that occur on time scales of less than one Titan day. The heat and momentum budgets we determine here will be useful in constraining the factors controlling the evolution of Titan's middle atmosphere over the coming decades.
Low-Intensity Pulsed Ultrasound Promotes the Repair of Achilles Tendinopathy by Downregulating the JAK/STAT Signaling Pathway in Rabbits

Tendinopathy is a complex tendon injury or pathology outcome, potentially leading to permanent impairment. Low-intensity pulsed ultrasound (LIPUS) is emerging as a treatment modality for tendon disorders. However, the optimal treatment duration and its effect on tendons remain unclear. This study aims to investigate the efficacy of LIPUS in treating injured tendons, delineate the appropriate treatment duration, and elucidate the underlying treatment mechanisms through animal experiments. Ninety-six three-month-old New Zealand white rabbits were divided into normal control (NC) and model groups. The model group received Prostaglandin E2 (PGE2) injections to induce Achilles tendinopathy. They were then divided into model control (MC) and LIPUS treatment (LT) groups. LT received LIPUS intervention with a 1-MHz frequency, a pulse repetition frequency (PRF) of 1 kHz, and spatial average temporal average sound intensity ( ${I}_{\text {SATA}}$ ) of 100 mW/cm2. MC underwent a sham ultrasound, and NC received no treatment. Assessments on 1, 4, 7, 14, and 28 days after LT included shear wave elastography (SWE), mechanical testing, histologic evaluation, ribonucleic acid sequencing (RNA-seq), polymerase chain reaction (PCR), and western blot (WB) analysis. SWE results showed that the shear modulus in the LT group was significantly higher than that in the MC group after LT for seven days. Histological results demonstrated improved tendon tissue alignment and fibroblast distribution after LT. Molecular analyses suggested that LIPUS may downregulate the Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway and regulate inflammatory and matrix-related factors. We concluded that LT enhanced injured tendon elasticity and accelerated Achilles tendon healing. The study highlighted the JAK/STAT signaling pathway as a potential therapeutic target for LT of Achilles tendinopathy, guiding future research.
Unmet Need for Family Planning and Spousal Separation in Nepal: A Spatial and Multilevel Analysis

Objectives: In Nepal, where increasing numbers of married couples live apart due to migration, progress in reducing unmet need for family planning (UMN) is stagnant. This study aims to identify spatial patterns of UMN of married women and spousal separation in Nepal and explore associations between UMN and spousal separation at individual- and district-levels. Methods: We used 2016 Nepal Demographic and Health Surveys data to conduct spatial and multilevel logistic analyses. Results: This study shows evidence of similar geographical patterns in UMN of married women and spousal separation. At the individual level, women living with their spouses had 88% (aOR = 0.12, 95% CI 0.11–0.13) decreased odds of experiencing UMN compared to those living apart from their spouses. While not statistically significant, increasing odds of UMN were observed with higher prevalence of spousal separation at the district level. Conclusion: This study contributes to the existing literature by showing similar geographical patterns of UMN and spousal separation across Nepal and demonstrating both individual and contextual effects of spousal separation on UMN among married women. Theoretical and policy implications are discussed.
Effect of grazing system on nitrogen partitioning in lactating dairy cows grazing irrigated pastures in Canterbury, New Zealand

Regulations currently being developed by Regional Councils throughout New Zealand to manage freshwater quality may require substantial reductions in nitrate leaching from dairy farms in many regions. The objective of this study was to quantify nitrogen intake, partitioning, and excretion in two irrigated farming systems in Canterbury, comparing different possible pathways for future industry development. A ‘higher input’ system (HI, n = 34 cows) was characterised by a stocking rate of 5 cows per/ha, ~300 kg/ha/year fertiliser N and ~1t DM/cow/year purchased supplement fed on the milking platform. The ‘lower input’ system (LI, n = 29 cows) used a stocking rate of 3.5 cows/ha, 150 kg/ha/year fertiliser N, and minimal purchased supplement. Urine, faeces, plasma, and milk samples were collected for N determination at consecutive afternoon and morning milkings once per month for four years. Estimated N intake did not differ between HI and LI (537 g N/cow/day and 557 g N/cow/day respectively, P = 0.29). No differences were recorded for N parameters and estimated milk and urine N output/cow was not affected by farm system. When scaled to per hectare, urinary N excretion was 33% greater for HI compared with LI (1.1 kg/ha/day and 0.8 kg/ha/day, respectively, P = 0.02).
Reemerging of Encephalomyocarditis Virus in Pigs in Brazil: Pathological and Viral Characterization

Encephalomyocarditis virus (EMCV) is a zoonotic disease caused by a highly pathogenic virus that affects wild and domestic animal species, with rodents as its reservoir. Most recently, in South America, this virus was detected in an outbreak affecting humans in Peru. In Brazil, EMCV infection was described in some wild species, in horses, and once in farrowing pigs. The aim of this study is to report the reemergence of EMCV in commercial growing–finishing pigs from two different farms that experienced sudden pig death in midwest Brazil. This aim was achieved through gross pathology, histologic examination, RT‒PCR analysis, and genetic characterization of the virus. Clinical signs, such as trembling, dyspnea, and squealing sounds shortly before death, were only occasionally observed and were nonspecific. On gross examination, cardiomegaly was observed, along with multifocal pale tan foci in the epicardium extending to the myocardium on the cut surface. Microscopically, there was severe myocardial necrosis, dystrophic mineralization, fibrosis, and lymphoplasmacytic and histiocytic myocarditis. Gross and microscopic examinations of the rats were unremarkable. The RT‒PCR analyses of the pig and rat organs were positive for EMCV, and the phylogenetic analysis of the VP1 gene showed that the samples from pigs and rats contained similar strains that had their closest relatives identified in humans in Peru. This is the first genetic characterization of EMCV in Brazil, and the other findings confirm the reemergence of the disease that was transmitted from rats to pigs.
DNS OF A TRANSITIONALLY ROUGH CHANNEL FLOW WITH A 3-D ROUGHNESS

A DNS study is performed to investigate turbulence in a steady-state channel flow at transitionally rough region (ks + = 8 − 41) with a smooth top surface and a roughened bottom surface made of close-packed pyramids at several Reynolds numbers. Simulations in a channel with all smooth walls are also conducted to facilitate direct comparison. The skin friction factor results show an inflection point at ks + ≈ 15. Reynolds stress and normal vorticity show a similarity in the logarithmic region. In the outer layer, however, it appears that smalland large-scales structures exhibit different sensitivities to the existence of roughness. While the dissipation and vorticity, which are representing the small-scale structures, collapse to the corresponding smooth-wall values, Reynolds stress quantities containing great contributions of the large-scale structures do not exhibit this behaviour for δ
Living with Chronic Pain: A Qualitative Study of the Daily Life of Older People with Chronic Pain in Chile

One of the main causes of chronic pain in older people is spine deformity, an abnormal curvature of the spine. The purpose of this study is to improve understanding of the experience of chronic pain produced by spinal deformity in older people and understand how cultural factors may affect this experience. A qualitative study was performed with 10 older people. Participants were encouraged to describe a typical day in their life, including the factors that affect their pain and how their quality of life had been affected since experiencing chronic pain. The semistructured interviews were transcribed and analyzed using open coding. Pain caused by spine deformity produces disability, affecting how older people perform their daily activities, causing them to adapt their households and physical positions to perform these tasks, albeit slowly or incompletely. Chronic pain also affects emotional states and social relationships because older people become unable to undertake physical activities that they performed in the past. The close relationship with adult children and friends, typical in Latin cultures, is a source of comfort and support. At a community level, adaptation of public services (such as public transportation) must be improved.
In Vitro Activities of Oxazolidinone Antibiotics Alone and in Combination with C-TEMPO against Methicillin-Resistant Staphylococcus aureus Biofilms

Infections caused by methicillin-resistant Staphylococcus aureus (MRSA) are a global health concern. The propensity of MRSA to form biofilms is a significant contributor to its pathogenicity. Strategies to treat biofilms often involve small molecules that disperse the biofilm into planktonic cells. Linezolid and, by extension, theoxazolidinones have been developed to treat infections caused by Gram-positive bacteria such as MRSA. However, the clinical development of these antibiotics has mainly assessed the susceptibility of planktonic cells to the drug. Previous studies evaluating the anti-biofilm activity of theoxazolidinones have mainly focused on the biofilm inhibition of Enterococcus faecalis and methicillin-sensitive Staphylococcus aureus, with only a few studies investigating the activity of oxazolidinones for eradicating established biofilms for these species. Very little is known about the ability of oxazolidinones to eradicate MRSA biofilms. In this work, five oxazolidinones were assessed against MRSA biofilms using a minimum biofilm eradication concentration (MBEC) assay. All oxazolidinones had inherent antibiofilm activity. However, only ranbezolid could completely eradicate MRSA biofilms at clinically relevant concentrations. The susceptibility of the MRSA biofilms to ranbezolid was synergistically enhanced by coadministration with the nitroxide biofilm dispersal agent C-TEMPO. We presume that ranbezolid acts as a dual warhead drug, which combines the mechanism of action of the oxazolidinones with a nitric oxide donor or cytotoxic drug.
Equatorial noise emissions observed by the DEMETER spacecraft during geomagnetic storms

Equatorial noise emissions are electromagnetic waves routinely observed in the equatorial region of the inner magnetosphere at frequencies between the proton cyclotron frequency and the lower hybrid frequency. Their observations are, however, typically limited to radial distances larger than about 2RE. We use the data measured by the low‐altitude DEMETER spacecraft (altitude of about 700 km) to confirm that during periods of enhanced geomagnetic activity, these emissions penetrate down to low radial distances and eventually become a dominant wave emission close to the proton cyclotron frequency in the equatorial region. Wave data obtained during six intense geomagnetic storms (Dst <− 100 nT) are analyzed. It is shown that during the analyzed time intervals, the daytime wave activity within about 20° from the geomagnetic equator is significantly enhanced, while the nightside wave activity shows a weaker increase at lower frequencies. Multicomponent wave data allow us to determine dayside wave propagation parameters. It is shown that the waves are nearly linearly polarized and their wave vector directions are almost perpendicular to the ambient Earth's magnetic field, as it has been previously observed for equatorial noise emissions. Finally, we analyze the dependence of the equatorial wave intensity at the proton cyclotron frequency on Dst and AE geomagnetic indices, and we demonstrate that the dayside wave intensity increases by as much as 3 orders of magnitude during severely disturbed periods.
Zuccagnia punctata Cav., a Potential Environmentally Friendly and Sustainable Bionematicide for the Control of Argentinean Horticultural Crops

This research was designed to investigate the metabolite profiling, phenolics, and flavonoids content as well as the potential nematicidal properties of decoction (ZpDe), orange-yellow resin (ZpRe) and essential oil (ZpEO) from Argentinean medicinal plant Zuccagnia punctata Cav. Additionally, the antioxidant and antibacterial properties of ZpDe and ZpEO were determined. Metabolite profiling was obtained by an ultrahigh-resolution liquid chromatography MS analysis (UHPLC-ESI-QTOF/OT-MS-MS) and GCMS. The nematicidal activity was assayed by a standardized method against Meloidogyne incognita. The antioxidant properties were screened by four methods: (2,2-diphenyl-1-picrylhydrazyl assay (DPPH), Trolox equivalent antioxidant activity assay (TEAC), ferric-reducing antioxidant power assay (FRAP), and lipid peroxidation in erythrocytes (ILP). The antibacterial activity was evaluated according to the Clinical and Laboratory Standards Institute (CLSI) rules. The ZpDe, ZpRe and ZpEO displayed a strong nematicidal activity with an LC50 of 0.208, 0.017 and 0.142 mg/mL, respectively. On the other hand, the ZpDe showed a strong DPPH scavenging activity (IC50 = 28.54 µg/mL); ILP of 87.75% at 250 µg ZpDe/mL and moderated antimicrobial activity. The ZpEO showed promising activity against a panel of yeasts Candida albicans and non-albicans (ATCC and clinically isolated) with MIC values from 750 to 1500 µg/mL. The ZpDe showed a content of phenolics and flavonoid compounds of 241 mg GAE/g and 10 mg EQ/g, respectively. Fifty phenolic compounds were identified in ZpDe by ultrahigh-resolution liquid chromatography (UHPLC–PDA– Q-TOF-MS) analysis, while forty-six phenolic compounds were identified in ZpRe by UHPLC-ESI-Q-OT-MS-MS and twenty-nine in ZpEO using a GC-MS analysis, updating the knowledge on the chemical profile of this species. The results support and standardize this medicinal plant mainly as a potential environmentally friendly and sustainable bionematicide for the control of Argentinean horticultural crops including tomatoes and peppers and as a source of antimicrobial and antioxidant compounds which could be further explored and exploited for potential applications.
Grain-size effect on uplift capacity of plate anchors in coarse granular soils

This letter investigates the uplift capacity of plate anchors in granular soils. Simulations based on a discrete-element method are used to measure the uplift capacity of anchors of differing widths to embedment B/H and width to grain-size B/d ratios. Results confirm that the uplift capacity of anchors with a large B/d ratio is well described by existing models developed from continuum mechanics, with no grain-size effect. In contrast, results reveal a strong deviation from these models for anchors with relatively small B/d ratios. A semi-empirical model is introduced that captures this strong grain-size effect. This model is further supported by a micro-mechanical analysis, indicating that anchor uplift capacities are not only governed by a frustum mechanism predicted by continuum mechanics but also involve the mobilisation of grains surrounding this frustum. These results and model are particularly important to rationalise uplift capacities measured in small-scale experiments, typically involving small .
Phenytoin-responsive epileptic encephalopathy with a tandem duplication involving FGF12

Nonsecreting fibroblast growth factors (FGFs), which are sodium channel–binding proteins, have recently been associated with neurodevelopmental disorders,1,2 similar to some voltage-gated sodium channel subunits. Recently, a de novo mutation in FGF12 (p.R52H) was reported in a pair of siblings with epileptic encephalopathies.3 The affected siblings developed severe seizures within 1 month of age, and their seizures were refractory to multiple antiepileptic drugs. This mutation has a gain-of-function effect on sodium channel gating, which might lead to increased neuronal excitability. Here, we report another case of FGF12-related epileptic encephalopathy. In contrast to the previous report, the phenotype in our patient was relatively mild. Of note, his seizures responded to phenytoin, a sodium channel blocker, similar to epileptic encephalopathy associated with SCN2A4 and SCN8A,5 encoding voltage-gated sodium channel subunits.
Determination of fatty acids in the seeds of Lepidium apetalum Willdenow, Descurainia sophia (L.) Webb ex Prantl, and Draba nemorosa L. by ultra-high-performance liquid chromatography equipped with a charged aerosol detector

Abstract Both the contents of fatty acids and the ratios of unsaturated to saturated fatty acids are important parameters for determining the nutritional values of oils. Thus, we herein evaluated the fatty acids present in the seed oils of Lepidium apetalum Willdenow, Descurainia sophia (L.) Webb ex Prantl, and Draba nemorosa L. as sources of Lepidii seu Descurainiae Semen seeds in Northeast Asian Countries. We developed a method based on ultra-high-performance liquid chromatography using a charged aerosol detector for the quantitative analysis of fatty acids in the seed oils. This technique is less time-consuming than previous methods as derivatization of the oils is not required. Our method was developed though the comparison of a UV detector with a charged aerosol detector, and various stationary phases and gradient programs were tested. In addition, method validation was carried out according to the International Conference on Harmonization guidelines with respect to linearity, precision, and accuracy. We found that the quantities of unsaturated fatty acids (6.051–282.376 mg/g) were higher than those of saturated fatty acids (0.855–12.548 mg/g) in all plant seed oils. The proposed method is reproducible and convenient, and therefore, is suitable for the quantitative analysis of fatty acids in plant oils. GRAPHICAL ABSTRACT
Metabolic patterns of sweat-extracellular vesicles during exercise and recovery states using clinical grade patches

Background: Metabolite-based sensors are attractive and highly valued for monitoring physiological parameters during rest and/or during physical activities. Owing to their molecular composition consisting of nucleic acids, proteins, and metabolites, extracellular vesicles (EVs) have become acknowledged as a novel tool for disease diagnosis. However, the evidence for sweat related EVs delivering information of physical and recovery states remains to be addressed. Methods: Taking advantage of our recently published methodology allowing the enrichment and isolation of sweat EVs from clinical patches, we investigated the metabolic load of sweat EVs in healthy participants exposed to exercise test or recovery condition. -Ten healthy volunteers (-three females and -seven males) were recruited to participate in this study. During exercise test and recovery condition, clinical patches were attached to participants’ skin, on their back. Following exercise test or recovery condition, the patches were carefully removed and proceed for sweat EVs isolation. To explore the metabolic composition of sweat EVs, a targeted global metabolomics profiling of 41 metabolites was performed. Results: Our results identified seventeen metabolites in sweat EVs. These are associated with amino acids, glutamate, glutathione, fatty acids, creatine, and glycolysis pathways. Furthermore, when comparing the metabolites’ levels in sweat EVs isolated during exercise to the metabolite levels in sweat EVs collected after recovery, our findings revealed a distinct metabolic profiling of sweat EVs. Furthermore, the level of these metabolites, mainly myristate, may reflect an inverse correlation with blood glucose, heart rate, and respiratory rate levels. Conclusion: Our data demonstrated that sweat EVs can be purified using routinely used clinical patches during physical activity, setting the foundations for larger-scale clinical cohort work. Furthermore, the metabolites identified in sweat EVs also offer a realistic means to identify relevant sport performance biomarkers. This study thus provides proof-of-concept towards a novel methodology that will focus on the use of sweat EVs and their metabolic composition as a non-invasive approach for developing the next-generation of sport wearable sensors.
UvA-DARE (Digital Academic Repository) Dynamics of political information transmission: How media coverage informs public judgments about politics

Representative democracy requires that citizens express informed political opinions. To do so, they must not only have access to relevant factual information and absorb what they need to know, but also use the acquired facts to update opinions accordingly. However, it remains unclear if citizens make “informed updates” of political judgments when relevant facts are available to them in a real-world media environment. Drawing on data from a two-wave panel survey and media content analysis, this article examines if exposure to facts about elite performance in the media alters judgments about such performance by way of inducing perfor-mance-relevant information. It also examines how this indirect exposure effect differs for people with different levels of motivation and sophistication for processing new political information. We find that relevant information encounters do not only induce learning, but can indirectly also change associated judgments as people use what they learn from exposure to revise these judgments. But our results also reveal how such impact of exposure is condi-tioned by personal characteristics: it is pronounced only among moderately sophisticated individuals with above-average motivation.