Miracle-dz/UniFAR-FTUs huggingface dataset:
The Correlation between Tumor Expansion, Neck Nodules,and Free Margin with the Stomal Recurrence Incidence after a Total Laryngectomy

Background: Stomal recurrence means a recurrence experienced by patients with laryngeal carcinoma after total laryngectomy with a high mortality rate. It is essential to identify the risk factors to predict stomal recurrence. However, factors contributing to stomal recurrence indicate controversial results. Tumor expansion, thyroid nodules, and free margins become the risk factors that are easily identified. The objective: This study aims to describe the correlation between tumor expansion, thyroid nodules, and free margins with stomal recurrence after total laryngectomy. Methods: This study applied an analytical observational study with retrospective cohort studies by employing secondary data. The samples included patients who had experienced a total laryngectomy from January 1, 2015, to December 31, 2019, and those who met the study criteria. The samples were divided into groups of T3 and T4 tumor expansion, groups of N1 and N2+ thyroid nodules, as well as groups of positive and negative free margins. These samples were associated with the stomal recurrence and categorized into yes and no accordingly. The Chi-Square Test was employed for correlation analysis and followed by multiple logistic regression. The results were considered correlated if the P-value was less than 0.05. Results: This study obtained 92 patients with 87 males and 5 females. The analysis of the correlation between tumor expansion and stomal recurrence suggested a P-value of 0.770, which was greater than 0.05. Meanwhile, the correlation between thyroid nodules and free margins with stomal recurrence indicated a P-value of 0.068 and 0.147, greater than 0.05. Conclusion: There was no significant correlation between tumor expansion, thyroid nodules, and free margins with stomal recurrence after a total laryngectomy.
Long-term considerations

A considerable body of evidence supports the view that haemodynamic factors, acting during growth and development, affect the ultimate form of the larger arteries. Many of the changes induced in vessels by high pressure or flow are adaptive and effectively minimise alterations in vessel function, but these changes may predispose to degenerative disease. 'Early intervention' in arterial disease implies intervention in the first and second decades of life.
Gaia Data Release 2

Aims. The Radial Velocity Spectrometer (RVS) on board the ESA satellite mission Gaia has no calibration device. Therefore, the radial velocity zero point needs to be calibrated with stars that are proved to be stable at a level of 300 m s−1 during the Gaia observations. Methods. We compiled a dataset of ~71 000 radial velocity measurements from five high-resolution spectrographs. A catalogue of 4813 stars was built by combining these individual measurements. The zero point was established using asteroids. Results. The resulting catalogue has seven observations per star on average on a typical time baseline of 6 yr, with a median standard deviation of 15 m s−1. A subset of the most stable stars fulfilling the RVS requirements was used to establish the radial velocity zero point provided in Gaia Data Release 2. The stars that were not used for calibration are used to validate the RVS data.
Multi-ROI Spectral Approach for the Continuous Remote Cardio-Respiratory Monitoring from Mobile Device Built-In Cameras

Heart rate (HR) and respiratory rate (fR) can be estimated by processing videos framing the upper body and face regions without any physical contact with the subject. This paper proposed a technique for continuously monitoring HR and fR via a multi-ROI approach based on the spectral analysis of RGB video frames recorded with a mobile device (i.e., a smartphone’s camera). The respiratory signal was estimated by the motion of the chest, whereas the cardiac signal was retrieved from the pulsatile activity at the level of right and left cheeks and forehead. Videos were recorded from 18 healthy volunteers in four sessions with different user-camera distances (i.e., 0.5 m and 1.0 m) and illumination conditions (i.e., natural and artificial light). For HR estimation, three approaches were investigated based on single or multi-ROI approaches. A commercially available multiparametric device was used to record reference respiratory signals and electrocardiogram (ECG). The results demonstrated that the multi-ROI approach outperforms the single-ROI approach providing temporal trends of both the vital parameters comparable to those provided by the reference, with a mean absolute error (MAE) consistently below 1 breaths·min−1 for fR in all the scenarios, and a MAE between 0.7 bpm and 6 bpm for HR estimation, whose values increase at higher distances.
Foliar Application of Leaf Extracts of Glycyrrhiza uralensis Increases Growth and Nutritional Value of Chinese Flowering Cabbage Plants under Field Conditions

Guangdong Key Laboratory for New Technology Research of Vegetables/Vegetable Research Institute, Guangdong Academy of Agricultural Sciences, Guangzhou 510640, China Department of Plant Pathology, Faculty of Agricultural Sciences, University of the Punjab, Lahore, Pakistan Directorate General of Pest Warning and Quality Control of Pesticides Punjab, 21 Davis Road Lahore, Lahore, Pakistan Department of Microbiology and Molecular Genetics, University of the Punjab, Lahore, Pakistan
Molecular and Cytogenetic Analysis of rDNA Evolution in Crepis Sensu Lato

Although Crepis was the first model plant group in which chromosomal changes were considered to play an important role in speciation, their chromosome structure and evolution have been barely investigated using molecular cytogenetic methods. The aim of the study was to provide a better understanding of the patterns and directions of Crepis chromosome evolution, using comparative analyses of rDNA loci number and localisation. The chromosome base number and chromosomal organisation of 5S and 35S rDNA loci were analysed in the phylogenetic background for 39 species of Crepis, which represent the evolutionary lineages of Crepis sensu stricto and Lagoseris, including Lapsana communis. The phylogenetic relationships among all the species were inferred from nrITS and newly obtained 5S rDNA NTS sequences. Despite high variations in rDNA loci chromosomal organisation, most species had a chromosome with both rDNA loci within the same (usually short) chromosomal arm. The comparative analyses revealed several independent rDNA loci number gains and loci repositioning that accompanied diversification and speciation in Crepis. Some of the changes in rDNA loci patterns were reconstructed for the same evolutionary lineages as descending dysploidy.
The CARMENES search for exoplanets around M dwarfs

Context. The nearby ultra-compact multiplanetary system YZ Ceti consists of at least three planets, and a fourth tentative signal. The orbital period of each planet is the subject of discussion in the literature due to strong aliasing in the radial velocity data. The stellar activity of this M dwarf also hampers significantly the derivation of the planetary parameters. Aims. With an additional 229 radial velocity measurements obtained since the discovery publication, we reanalyze the YZ Ceti system and resolve the alias issues. Methods. We use model comparison in the framework of Bayesian statistics and periodogram simulations based on a method by Dawson and Fabrycky to resolve the aliases. We discuss additional signals in the RV data, and derive the planetary parameters by simultaneously modeling the stellar activity with a Gaussian process regression model. To constrain the planetary parameters further we apply a stability analysis on our ensemble of Keplerian fits. Results. We find no evidence for a fourth possible companion. We resolve the aliases: the three planets orbit the star with periods of 2.02 d, 3.06 d, and 4.66 d. We also investigate an effect of the stellar rotational signal on the derivation of the planetary parameters, in particular the eccentricity of the innermost planet. Using photometry we determine the stellar rotational period to be close to 68 d and we also detect this signal in the residuals of a three-planet fit to the RV data and the spectral activity indicators. From our stability analysis we derive a lower limit on the inclination of the system with the assumption of coplanar orbits which is imin = 0.9 deg. From the absence of a transit event with TESS, we derive an upper limit of the inclination of imax = 87.43 deg. Conclusions. YZ Ceti is a prime example of a system where strong aliasing hindered the determination of the orbital periods of exoplanets. Additionally, stellar activity influences the derivation of planetary parameters and modeling them correctly is important for the reliable estimation of the orbital parameters in this specific compact system. Stability considerations then allow additional constraints to be placed on the planetary parameters.
Dealing with the Demands of Language Testing

A remarkable amount of teacher time is devoted to assessment and testing. Assessment is the broader term, encompassing any activity in which data is collected from learners from which we make judgments about their proficiency or progress. It includes, for example, informal classroom quizzes, and peer- and self-assessment, and is free from the restrictions imposed by formal testing (Fulcher, 2010: 67-92). Testing is the more specific term that refers to formal or standardized testing for the purposes of certification or decision-making. Tests are usually constructed and provided by examination agencies with the authority to issue certificates that are recognised for purposes such as entry to higher education, or employment. The purpose of this chapter is to introduce teachers and students of applied linguistics to the key concepts and terminology needed to understand the role of standardized language testing and of assessment in the language classroom, and to utilise the testing and assessment literature. We discuss assessment for learning, i.e. how teachers can embed assessment into classroom activities to enhance learning opportunities. We consider the politics of externally mandated testing, and the role of teachers in preparing learners to take examinations. This is a highly controversial area, and so we make recommendations for best practice based upon the concept of ‘reverse engineering’. The chapter concludes with a discussion of assessment literacy for language teachers.
Impact of various herbicides on dicot weeds in wheat (Triticum aestivum L.)

A field study was conducted at Research Area of Agronomy, Ayub Agricultural Research Institute, Faisalabad, Pakistan during the year of 201415 to assess the comparative efficacy of different herbicides on control of dicot weeds, and subsequent effect on grain yield of wheat. The herbicide treatments comprised of T1 = Starane-M @ 750 ml/ha, T2 = Flock @ 700 ml/ha, T3 = Harvester 750ml/ha, T4 = Harvester pro @ 1000 ml/ha, T5 = Tanical @ 700 g/ha, T6 = Timber @ 700 g/ha, T7 = Jupitor @ 750 ml/ha, T8 = Buctril Super @ 750 ml/ha, T9 = Broxtra @ 750 ml/ha, T10 = Buctril M @ 750 ml/ha, T11 = Atlantus @ 400 g/ha, T12 = Hussar @ 100 ml/ha, T13 = Control (weedy check). The experiment was laid out under randomized complete block design in triplicate with a net plot size of 2.4 m × 8.0 m. The results revealed that herbicides application controlled the dicot weeds growth and a significant (P ≤ 0.05) reduction in weeds density versus weedy check was observed. Broxtra @ 750 ml ha -1 , Hussar @ 100 ml ha -1 , Jupitor @ 750 mL ha -1 and Starane-M @ 750 mL ha -1 ) effect was more pronounced as compared to control. Furthermore, grain yield and yield components of wheat improved considerably with herbicides application as compared to weedy check. Number of tillers, plant height, Spike length, number of spikelet/spike, number of grains per spike, 1000-grain weight, biological and grain yield were significantly higher in treated plots as compared to the control. Hussar @ 100 mL ha -1 gave maximum grain yield, which could possibly used for herbicides control in wheat crop with a considerable higher yield.
Manipulation of Large-Scale Vortical Structures and Mixing in a Coaxial Jet with Miniature Jet Actuators Toward Active Combustion Control

Manipulation of large-scale vortical structures and associated mixing in a methane-air coaxial jet is carried out by using miniature jet actuators installed on the inner surface of the annular nozzle. The periodic radial miniature jet injections are achieved with a rapid-response servo-valve. The spatio-temporal primary jet structures are investigated through phase-locked 2C-PIV (2 Component Particle Image Velocimetry) and stereoscopic-PIV. It is found that intense ring-like vortices are produced perfectly in phase with the periodic miniature jet injections regardless of the valve-driven frequency fv examined. When the Strouhal number Stv, which is defined with fv, is larger than unity, the ring-like vortices are densely formed and thus methane/air mixing is prompted with low periodic fluctuation. The diameter of the vortices becomes small as Stv is increased, so that the transport range of the inner methane and outer air fluids can be controlled by changing Stv. In addition, the evolution of counter-rotating vortex pair is also observed in the cross-sectional plane. These streamwise vortices are directly formed as a result of the radial miniature jet injection, which leads to entrainment of the ambient fluid near the primary jet shear layer, and they also contribute to the mixing enhancement. Moreover, it is demonstrated that coaxial jet flame characteristics such as carbon monoxide (CO) emission and flame holding can be drastically improved under different equivalence ratios by the present jet control scheme.
Design of Solar PV

One of the major concerns in the power sector is the day-to-day increasing power demand but the unavailability of enough resources to meet the power demand using the conventional energy sources. Solar Photovoltaic (PV) is a technology that converts sunlight directly into electrical energy. When the entire array does not receive uniform insolation under partial shaded conditions affect the power output of solar system. This paper presents Design of solar PV as DER (Distributed Energy resources) and its mathematical modeling and its P-V and I-V characteristics and compared with MSX60 PV module under various temperature levels. ________________________________________________________________________________________________________
3D elastic time-frequency full-waveform inversion

In this work I present the theory and implementation of a 3D elastic full waveform inversion. The implementation is based on the adjoint-state method using a time-frequency approach. Synthetic applications in transmission acquisition geometry show the ability of the method to reconstruct elastic parameters of different 3D subsurface structures. Optimisations with the diagonal Hessian matrix for preconditioning and the L-BFGS scheme enable the inversion of more complex surface geometry data.
RAINBOW NUMBERS FOR x 1 + x 2 = kx 3 IN Z n

In this work, we investigate the fewest number of colors needed to guarantee a rainbow solution to the equation x 1 + x 2 = kx 3 in Z n . This value is called the rainbow number and is denoted by rb ( Z n , k ) for positive integer values of n and k . We ﬁnd that rb ( Z p , 1) = 4 for all primes greater than 3 and that rb ( Z n , 1) can be determined from the prime factorization of n . Furthermore, when k is prime, rb ( Z n , k ) can be determined from the prime factorization of n .
Impact of product modular design on agile manufacturing

Modularization of products gives many benefits for different functions within a manufacturing company, both for manufacturing and for other business functions and processes. In this paper, common terms and methods used in product management and managing the product variety are presented. The main objective in this paper is to increase understanding of the concept of modularization on product design. It is described the special characteristics of the project business to the products and their modularity. In the empirical part a preliminary model for analysing the degree and form of modularisation in products is created. The core idea is to analyse and describe dimensions of the existing modularity of the product. Finally this analysis is applied to some key modules of recovery boilers.
Transcriptomic analysis of the innate immune signatures of a SARS-CoV-2 protein subunit vaccine ZF2001 and an mRNA vaccine RRV

ABSTRACT Analysis of large-scale gene expression post vaccination can provide an overview of immune responses. We used transcriptional approaches to comprehensively analyze the innate immune response signatures elicited by protein subunit (PS) vaccine ZF2001 and an mRNA vaccine named RRV. A fine-grained time-dependent dissection of large-scale gene expression post immunization revealed that ZF001 induced MHC class II-related genes, including cd74 and H2-Aa, more expeditiously than the RRV. Notably, the RRV induced MHC class I-related genes such as Tap1/2, B2m, and H2-D1/K1. At day 21 post immunization, the titres of binding and neutralization antibody (NAb) induced by both vaccines were comparable, which were accordant with the expression level of genes essential to BCR/TCR signalling transduction and B/T cells activation at day 7. However, compared to ZF2001, the early responses of RRV were more robust, including the activation of pattern recognition receptors (PRRs), expression of genes involved in RNA degradation, and transcription inhibition, which are directly related to anti-viral signals. This pattern also coincided with the induction of cytokines by the RRV. Generally, the transcriptomic patterns of two very different vaccines mapped here provide a framework for establishing correlates between the induction of genes and protection, which can be tailored for evoking specific and potent immune responses against SARS-CoV-2.
Effects of tetraethylammonium‐sensitive K+ channel blockade on cholinergic and thermal sweating in endurance‐trained and untrained men

What is the central question of this study? Does inhibition of K+ channels modulate the exercise‐training‐induced augmentation in cholinergic and thermal sweating? What is the main finding and its importance? Iontophoretic administration of tetraethylammonium, a K+ channel blocker, blunted sweating induced by a low dose (0.001%) of the cholinergic agent pilocarpine, but not heat‐induced sweating. However, no differences in the cholinergic sweating were observed between young endurance‐trained and untrained men. Thus, while K+ channels play a role in the regulation of eccrine sweating, they do not contribute to the increase in sweating commonly observed in endurance‐trained adults. Our findings provide important new insights into the mechanisms underlying the regulation of sweating by endurance conditioning.
Targeted delivery of quercetin by biotinylated mixed micelles for non-small cell lung cancer treatment

Abstract Lung cancer is the leading cause of cancer death world-wide and its treatment remains a challenge in clinic, especially for non-small cell lung cancer (NSCLC). Thus, more effective therapeutic strategies are required for NSCLC treatment. Quercetin (Que) as a natural flavonoid compound has gained increasing interests due to its anticancer activity. However, poor water solubility, low bioavailability, short half-life, and weak tumor accumulation hinder in vivo applications and antitumor effects of Que. In this study, we developed Que-loaded mixed micelles (Que-MMICs) assembled from 1,2-distearoyl-sn-glycero-3-phosphoethanolamine–poly(ethylene glycol)–biotin (DSPE–PEG–biotin) and poly(ethylene glycol) methyl ether methacrylate–poly[2-(dimethylamino) ethyl acrylate]–polycaprolactone (PEGMA–PDMAEA–PCL) for NSCLC treatment. The results showed that Que was efficiently encapsulated into the mixed micelles and the encapsulation efficiency (EE) was up to 85.7%. Cellular uptake results showed that biotin conjugation significantly improved 1.2-fold internalization of the carrier compared to that of non-targeted mixed micelles. In vitro results demonstrated that Que-MMICs could improve cytotoxicity (IC50 = 7.83 μg/mL) than Que-MICs (16.15 μg/mL) and free Que (44.22 μg/mL) to A549 cells, which efficiently induced apoptosis and arrested cell cycle. Furthermore, Que-MMICs showed satisfactory tumor targeting capability and antitumor efficacy possibly due to the combination of enhanced permeability and retention (EPR) and active targeting effect. Collectively, Que-MMICs demonstrated high accumulation at tumor site and exhibited superior anticancer activity in NSCLC bearing mice model.
Evaluation of dyslipidemia in preeclamptic pregnant women and determination of the predictive value of the hemato-lipid profile: A prospective, cross-sectional, case-control study

Objective: In this study, we examined the serum hematologic and lipid parameters of pregnant women with preeclampsia and an age- and gestational-age matched normotensive control group. We also compared the ratios of hemato-lipid parameters defined as systemic inflammatory markers and determined the predictive value of these values in preeclampsia. Materials and Methods: All patients diagnosed with late-onset preeclampsia or severe preeclampsia between 34 and 40 weeks of gestation at Inonu University Faculty of Medicine between March 2019 and October 2020 were included. Results: A total of 253 pregnant women were included in the study period. When the study groups were compared in terms of hematological and blood lipid profile; while serum lymphocyte, triglyceride, and total cholesterol levels were significantly higher in the preeclampsia group than in the control group (p<0.001, p<0.001, p=0.013, respectively); high-density lipoprotein (HDL)-cholesterol levels were found to be significantly lower (p=0.017). The cut-off value for the monocyte/HDL ratio in predicting severe preeclampsia was 16.65 with 59.0% sensitivity and 85.4% specificity [the area under the receiver operating characteristic 0.756, 95% confidence interval (CI) 0.681-0.821, p<0.001]. Multivariate analysis showed that the monocyte/HDL ratio was independently associated with both preeclampsia and severe preeclampsia [odds ratio (OR): 1.094; 95% CI 1.009-1.185 and OR: 1.731; 95% CI 1.218-2.459, respectively]. Conclusion: This study demonstrated that serum triglyceride and total cholesterol levels were significantly higher and serum HDL-cholesterol levels were significantly lower in pregnant women with late-onset preeclampsia compared to normotensive pregnant women. Additionally, this study revealed that the measurement of monocyte/HDL ratio in the pregnant population could be a useful clinical tool for predicting preeclampsia.