Miracle-dz/UniFAR-FTUs huggingface dataset:
Intolerance of uncertainty, fear of contamination and perceived social support as predictors of psychological distress in NHS healthcare workers during the COVID-19 pandemic

ABSTRACT Psychological distress has been repeatedly quantified over the course of the pandemic, however this has not always included broader healthcare workers, and has mostly focused on prevalence and occupational factors. This study investigated intolerance of uncertainty (IOU), fear of contamination and perceived social support as key predictors of psychological distress in healthcare professionals, between the 10th and 23 June 2020, during the first wave of the COVID-19 pandemic. This study was a cross-sectional, online survey design. Opportunity sampling was used to recruit to the study, primarily using social media sites and snowballing techniques. The final sample included 342 National Health Service (NHS) healthcare workers. IU (p < .001), gender (p < .001), fear of contamination (p = .007), perceived social support (p = .012), and age (p = .017) significantly predicted psychological distress in the sample and accounted for 36.2% of variance in psychological distress scores. IOU accounted for 28.2% of this variance. A two-way post hoc ANOVA, looking at gender and profession, showed a significant main effect of gender on psychological distress scores (F(1,218) = 7.156, p = . 008, ηp 2 = . 032), with females reporting significantly higher psychological distress scores compared to males. In conclusion, higher levels of intolerance of uncertainty, fear of contamination and lower levels of perceived social support significantly influenced higher scores of psychological distress. These factors should be considered when adapting and delivering evidence-based interventions to healthcare staff during this crisis.
INVESTIGATION OF ALUMINUM TOXICITY AMONG WORKERS IN ALUMINUM INDUSTRY SECTOR

The study was conducted to evaluate urine aluminum concentration among a total of 150 participants (80 aluminum technicians and 70 non- aluminum technicians as a control). Data were collected through a previously prepared questionnaire which consists of two parts. The first part concerned with demographic data such as age and nationality. The second part concerned with occupational data such as working hours, working years, smoking, and diseases. The mean concentration of aluminum is 51.62+ 29.59 μg/l and the mean concentration of group control 16.32 + 12.49 μg/l. The following variables were associated significantly with aluminum concentration: age, weekly working hours, smoking and daily smoking packets. According to our study, aluminum workers have high concentrations of urine aluminum compared with other studies, in addition to that the incidence of diseases in relation to exposure is low, simply because: 1-Self reported questionnaires may be not a proper way to collect data about diseases. 2- Traditional surveillance approaches used in public health practice are difficult to apply to metals poisoning because adverse health effects related to metal exposure may not be clinically diagnosed, except at very high exposure levels, and are not usually listed as reportable diseases. Finally Special safety precautions and educational programs are also needed to limit the aluminum exposure in this industrial group.
DESTINY-Changing Results for Advanced Breast Cancer.

The implications of the results of the DESTINY-Breast04 trial reported by Modi et al. 1 in this issue of the Journal are difficult to overstate. Im-mediately practice-changing, these data show that a human epidermal growth factor receptor 2 (HER2)–directed therapy, trastuzumab deruxtecan, leads to significant and striking improve-ments in both progression-free survival and overall survival as compared with chemotherapy among patients with metastatic breast cancer with low expression of HER2. Consistent benefit was observed in patients with poor prognostic indica-tors, including triple-negative cancer. Although the trophoblast cell-surface antigen 2 (Trop-2)– targeted antibody–drug conjugate sacituzumab govitecan has improved outcomes in patients with heavily pretreated triple-negative disease, the median progression-free survival of just under 6 months and overall survival of approximately 1 year 2 are lower than those reported in the 40 patients with triple-negative disease treated with trastuzumab deruxtecan (8.5 months and 18.2 months, respectively). A randomized trial is, of course, needed to compare these two agents, and sequencing studies are required to address wheth-er cross-resistance develops among antibody–drug conjugates comprising similar cytotoxic payloads like those in sacituzumab govitecan and trastuzumab deruxtecan.
E-Cigarette and Cannabis Use Patterns, Depression, and Suicide Behaviors Among US Youth: Analysis of 2019 Youth Risk Behavior Survey Data

Purpose To examine the associations of current electronic cigarette and cannabis use patterns with depression symptoms and suicidal ideation and behavior overall and stratified by sex among U.S. high school students. Design Quantitative, cross-sectional study. Setting The 2019 National Youth Risk Behavior Survey. Subjects 12,401 high school students in 9th−12th grade. Measures Dependent variables were depression symptoms, suicidal ideation, suicide plan, suicide attempt, and suicide attempt-related injury. Independent variables were past 30 day e-cigarette and cannabis use patterns. Covariates included demographics, grade level, and other tobacco product use. Analysis Multivariable logistic regression models. Results Approximately 15.7% of students were exclusive e-cigarette users, 4.5% were exclusive cannabis users, and 16.4% were concurrent e-cigarette and cannabis users. Exclusive e-cigarette and cannabis users, and concurrent users were at increased odds (P < .05) of having depression symptoms, seriously considered attempting suicide, planning suicide, suicide attempt, and having suicide attempt-related injury compared to non-users. Female users, especially concurrent users, had higher odds of reporting depression symptoms (P < .01) and all suicidal ideation and behavior outcomes (P < .01) than female non-users, but results varied for male students. Conclusion E-cigarette and cannabis use patterns significantly predicted depression symptomatology and suicidal ideation and behavior, with female students having higher odds. Results suggest the need for tailored interventions to address mental health and suicidality among U.S. adolescents, and especially female students.
Rare juvenile material constrains estimation of skeletal allometry in Gryposaurus notabilis (Dinosauria: Hadrosauridae)

In studying the skeletal allometry of any vertebrate, it is important to sample the ontogenetic extremes to ensure the accuracy of parameter estimation; this is particularly true for fossil taxa, where sampling of ontogenetic series is incomplete and sporadic. Previous studies have examined allometry in the skull of the duck‐billed dinosaur Gryposaurus notabilis, but these did not include individuals smaller than ~65% the maximum known size (based on linear dimensions). Here, we report on the two smallest known examples of this species (a mostly complete skeleton and a partial skull), which are ~37% the known maximal size of G. notabilis. Osteohistology indicates that these represent individuals ~2 years of age. Allometric analysis demonstrates that most aspects of the skull of G. notabilis grew isometrically, although the height of the nasal arch grew with positive allometry. Early in the ontogeny of G. notabilis, the dentary teeth possessed secondary ridges, which were lost later in life. This finding has important bearing on hadrosaurid tooth taxonomy. The limb proportions of G. notabilis largely grew isometrically (or with weak negative allometry, at most), like some other hadrosaurids, suggesting that the species did not undergo a gait shift with increasing age (unless it occurred very early in ontogeny). We argue that the lack of significant locomotory performance compensation exhibited by young hadrosaurids helps to explain why they apparently formed small, mutualistic aggregations, presumably for protection from large predators.
Maintaining a medical institution in a context of materiality change: Lessons from a Canadian university hospital

This research aimed to better understand how institutions are maintained, and the role of materiality in this institutional work. More specifically, the present qualitative case study analyzed how different actors in a large academic hospital in Canada worked together (i.e. accomplished institutional work) to maintain the institution of medical record keeping as a new clinical information system (computerized physician order entry-the material entity) was enacted. The study reveals that, to maintain the institution at stake, the intertwinement of processes of creating and maintaining institutions took place. In fact, different forms of institutional work interact Results also strongly suggest that the design of computerized physician order entry and its implementation (i.e. the materiality involved in this institutional change) played an important role in the maintenance of the institution of medical record keeping: on the one hand, it was particularly present in three types of institutional work, namely enabling, policing, and deterring; on the other hand, it appeared to be an essential component of the routinization of work by allowing a better fit between the new technology and the organization of work
Could Blood Hexosylsphingosine Be a Marker for Parkinson's Disease Linked with GBA1 Mutations?

We read with great interest the discussion on the topic if glucosylsphingosine (GlcSph) could be viewed as a biomarker for Parkinson ’ s (PD) disease in the carriers of the mutations in the glucocerebrosidase (GCase; GBA1 ) gene between Surface et al 1 and Gleason et al. 2 Surface et al 1 demonstrated that a single N370S allele is suf ﬁ cient to result in a signi ﬁ cant increase of plasma GlcSph concentration compared with patients with PD without GBA1 mutations and controls independent of PD status. Based on our data, we could extend the conclusion made by Surface et al 1 to L444P heterozygotes as well. We measured hexosylsphingosine (HexSph) (GlcSph and galactosylsphingosine) concertation and GCase activity in dry blood spots (DBSs) from patients with Gaucher ’ s disease (GD; n = 37), patients with PD with GBA1 mutations (GBA + /PD + ; n = 18), healthy GBA1 mutations carriers (GBA + /PD (cid:1) ; n = 21), patients with sporadic PD (sPD; n = 177), and control subjects (n = 170).
Genome-wide association study for morphological traits and resistance to Peryonella pinodes in the USDA pea single plant plus collection

Abstract Peas (Pisum sativum) are the second most cultivated pulse crop in the world. They can serve as human food, fodder, and cover crop. The most serious foliar disease of pea cultivars worldwide is Ascochyta blight, which can be caused by several pathogens. Of these, Peyronella pinodes is the most aggressive and prevalent worldwide. Several traits, including resistance to Peyronella pinodes, stem diameter, internode length between nodes 2–3 and 5–6, and area of 7th leaf, were measured in 269 entries of the pea single plant plus collection. The heritability (H2) of the morphological traits was relatively high, while disease resistance had low heritability. Using 53,196 single-nucleotide polymorphism markers to perform a genome-wide association study to identify genomic loci associated with variation in all the traits measured, we identified 27 trait–locus associations, 5 of which were associated with more than 1 trait.
Fifteen-Month Follow-Up of Anti-Spike Receptor-Binding Domain SARS-CoV-2 Antibodies among Healthcare Workers in Boston, MA.

BACKGROUND Boston Medical Center (BMC) is a safety net hospital in Boston, and from the initial wave of COVID-19 there has been an overwhelming concern about the exposure of healthcare workers (HCWs) to SARS-CoV-2. METHODS We conceived a study to follow a cohort of BMC HCWs, beginning in July 2020 and continuing for 15 months, collecting survey data and serum samples at approximately 3-month intervals. Serum samples were analyzed using the Abbott Architect i2000 for SARS-CoV-2 antibodies (anti-spike1-Receptor Binding Domain IgG and anti-nucleoprotein IgG). Positive anti-n IgG results were used, in addition to reverse transcription-PCR results, for identifying cases of infection. History of COVID-19 and vaccination status were confirmed, where possible, using electronic medical records. Participants were grouped according to vaccination and infection status in September 2021 for analysis of anti-s IgG trends. RESULTS A majority of HCWs remain well above the positivity threshold for anti-spike IgG antibodies for up to 11 months post-vaccination and 15 months post-infection, regardless of combinations and permutations of vaccination and infection. Those with COVID-19 infection before vaccination had significantly higher median serum antibody concentrations in comparison to HCWs with no prior infection at each follow-up time point. CONCLUSIONS These findings further support what is known regarding the decline in serum antibody concentrations following natural infection and vaccination, adding knowledge of serum antibody levels for up to 15 months post- infection and 11 months post-vaccination.
FIGNL1 is a potential biomarker of cisplatin resistance in non-small cell lung cancer

Background Fidgetin-like 1 (FIGNL1) participates in tumor resistance by playing the function of homologous recombination repair(HRR). However, the role of FIGNL1 in non-small cell lung cancer (NSCLC) is still unclear. This study aims to understand the expression of FIGNL1 in NSCLC and preliminarily explore its relationship with cisplatin resistance. Methods FIGNL1 messenger RNA (mRNA) was analyzed in 1018 NSCLC tissues and 111 adjacent tissues using The Cancer Genome Atlas program. FIGNL1mRNA in cisplatin-resistant and cisplatin-sensitive cell lines was analyzed by the Gene Expression Omnibus project. FIGNL1 protein was detected in 58 NSCLC tissues and 58 adjacent tissues by immunohistochemistry. The relationship between FIGNL1, clinical pathological characteristics and disease-free survival was retrospectively analyzed. Gene ontology was used to analyze the biological process mainly involving FIGNL1, and STRING online constructed its protein interaction network and screened the key genes (hub genes). Results The Cancer Genome Atlas showed that FIGNL1mRNA was higher in 1018 NSCLC tissues than in 111 adjacent tissues (P < 0.05). In the dataset “GSE157692,” FIGNL1mRNA was higher in cisplatin-resistant cell lines (P = 3.80e-05). The hub genes in FIGNL1 and HRR directions are RAD51 and CCDC36. Immunohistochemistry showed that the FIGNL1 protein in 58 NSCLC tissues was higher than that in 58 adjacent tissues (P < 0.01). FIGNL1 is associated with gender, histopathological type, and nerve invasion in NSCLC. The disease-free survival in NSCLC patients with high FIGNL1 expression was shorter (P = 0.032). Conclusion FIGNL1 is associated with poor prognosis in NSCLC, and cisplatin resistance may be involved. These observations provide a clinical basis for exploring FIGNL1 as a potential biomarker for cisplatin resistance in NSCLC.
Knowledge, perception, and fear among the global population towards newly evoked variant Omicron (B.1.1.529)

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-1), notoriously known as COVID-19, emerged in 2019 and was responsible for causing acute respiratory collapse. Moreover, in September 2020, new variant cases of severe acute respiratory syndrome coronavirus 2 were reported in the United Kingdom, with many patients and deaths. This study aimed to see knowledge, perception, and fear among the global population towards a new variant of severe acute respiratory syndrome coronavirus 2, known as Omicron (B.1.1.529). This online cross-sectional global study was conducted during the emergence of the B.1. 1.529 variant, also known as the Omicron variant. The survey was carried out from 2nd December 2021 to 3rd January 2022. The descriptive analysis was presented as frequencies (N), percentages (%), and mean ± standard deviation (m ± SD). The association between dependent and categorical independent variables was determined using the Chi-square test (x2). Statistical analysis was performed by using SPSS version 23. Of 353 respondents, approximately 61% were females. One hundred fifty-four respondents were in the age group of 18–27 years. The average age was 31.53±10.3 (mean± SD). The majority of respondents (43.9%) were from Indonesia. The mean knowledge score about the Omicron variant was 3.18±1.14. Our study suggests that people have some knowledge about the new variant, Omicron (B.1.1.529). Besides, there was a significant association (p = 0.05) for the perception of the fatality rate of Omicron among the respondents from different countries. However, there is still an ample research gap in enlightening people about this infection (B.1.1.529).
The Role of Self-Study in Addressing Competency Decline Among Airline Pilots During the COVID-19 Pandemic

Objective This study aimed to investigate the self-study methods used by pilots while grounded and their perception of competence decline and confidence upon their return to flying. Background Previously, long absences from flying were managed on a case-by-case basis. Thousands of pilots returning to flying as the pandemic eases have burdened airline training systems. Limited research has been conducted on the decline in skills of airline pilots while operationally absent from the cockpit. Few studies have considered this topic in the context of a pandemic. Method A questionnaire study was conducted with 234 airline pilots who were grounded during the COVID-19 pandemic. Results Uncertainty regarding sudden and indefinite periods of grounding made it challenging to maintain motivation to self-study. This matter was aggravated by the additional financial and personal stress caused by the state of the airline industry and the outcomes of the pandemic. The participants anticipated a decline in manual flying skills as the worst outcome after being absent from the flight deck. However, these pilots proved quick to recover these skills when they resumed flying. It took significantly more time for pilots to regain proficiency in applying knowledge, procedures and compliance with regulations, situation awareness and workload management. Conclusion The study proposes recommendations for pilots and airlines to harness essential self-study practices in competency areas identified to have significantly declined. Application The outcome of this paper guides airlines, pilots and regulators in better understanding how grounded pilots observe skill decline in a broader range of competencies.
Perfluorooctanoic Acid Affects Mouse Brain and Liver Tissue Through Oxidative Stress

Abstract The aim of this study was to investigate oxidative stress induced by perfluorooctanoic acid (PFOA) in the brain and liver tissues of Balb/c mice as well as protective effects of taurine and coenzyme Q10 (CoQ10) in both organs. For this purpose, animals were treated with PFOA (15 and 30 mg/kg) orally and their lipid peroxidation, total glutathione levels (GSH), and antioxidant enzyme activities measured and both tissues analysed for histopathological changes. Our results showed a dose-dependent decrease in body weight and increase in relative brain and liver weights, PFOA-induced lipid peroxidation and reduced glutathione peroxidase (GPx) activity in the brain tissue, and changes in GSH levels, GPx, superoxide dismutase (Cu-Zn SOD), and catalase (CAT) activities in the liver tissue. Pre-treatment with taurine or CoQ10 provided protection against PFOA-induced Cu-Zn SOD reduction in the liver tissue. Our findings evidence the depleting effect of PFOA on antioxidative systems and confirm that PFOA exerts its (neuro)toxicity through oxidative stress, but further research is needed to identify the exact toxicity mechanisms, especially in the brain.
Update on thyroid eye disease: Regional variations in prevalence, diagnosis, and management

Thyroid eye disease (TED) is a rare disease that can lead to decreased quality of life, permanent disfigurement, and vision loss. Clinically, TED presents with exophthalmos, periorbital edema, extraocular muscle dysfunction, and eyelid retraction, and can lead to vision-threatening complications such as exposure to keratopathy and dysthyroid optic neuropathy (DON). Over the last several years, significant advancements have been made in the understanding of its pathophysiology as well as optimal management. Ethnic variations in the prevalence, clinical presentation, and risk of vision-threatening complications of TED are summarized, and risk factors associated with TED are discussed. Additionally, significant advances have been made in the management of TED. The management of TED traditionally included anti-inflammatory medications, orbital radiation therapy, orbital surgical decompression, and biologic therapies. Most recently, targeted therapies such as teprotumumab, an insulin-like growth factor-1 receptor antagonist, have been studied in the context of TED, with promising initial data. In this review, updates in the understanding and management of TED are presented with a focus on the international variations in presentation and management.
Relationship between consolidation tumor ratio and tumor‐infiltrating lymphocytes in small‐sized lung adenocarcinoma

Consolidation tumor ratio (CTR) is associated with cancer progression and histological invasiveness in lung adenocarcinoma (LAD). However, little is known about the association between CTR and immune‐related factors, including tumor‐infiltrating lymphocytes (TILs) density or tumor expression of programmed death ligand 1 (PD‐L1) and indoleamine 2,3‐dioxygenase 1 (IDO1) in small‐sized LAD.