Miracle-dz/UniFAR-FTUs huggingface dataset:
A Comprehensive and Bias-Free Machine Learning Approach for Risk Prediction of Preeclampsia with Severe Features in a Nulliparous Study Cohort

Objective Preeclampsia is one of the leading causes of maternal morbidity, with consequences during and after pregnancy. Because of its diverse clinical presentation, preeclampsia is an adverse pregnancy outcome that is uniquely challenging to predict and manage. In this paper, we developed machine learning models that predict the onset of preeclampsia with severe features or eclampsia at discrete time points in a nulliparous pregnant study cohort. Materials and Methods The prospective study cohort to which we applied machine learning is the Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-to-be (nuMoM2b) study, which contains information from eight clinical sites across the US. Maternal serum samples were collected for 1,857 individuals between the first and second trimesters. These patients with serum samples collected are selected as the final cohort. Results Our prediction models achieved an AUROC of 0.72 (95% CI, 0.69–0.76), 0.75 (95% CI, 0.71–0.79), and 0.77 (95% CI, 0.74–0.80), respectively, for the three visits. Our initial models were biased toward non-Hispanic black participants with a high predictive equality ratio of 1.31. We corrected this bias and reduced this ratio to 1.14. The top features stress the importance of using several tests, particularly for biomarkers and ultrasound measurements. Placental analytes were strong predictors for screening for the early onset of preeclampsia with severe features in the first two trimesters. Conclusion Experiments suggest that it is possible to create racial bias-free early screening models to predict the patients at risk of developing preeclampsia with severe features or eclampsia nulliparous pregnant study cohort.
Acute coronary syndromes: hospital management of dyslipidaemia with proprotein convertase subtilisin/kexin 9 inhibitors: time to act

Abstract Atherosclerotic cardiovascular disease (ASCVD) in its countless clinical presentations is, in industrialized countries, the most frequent cause of death and, in recent years, a leading role in the prevention of ASCVD has been attributed to the treatment of dyslipidaemias. If statins and ezetimibe remain the cornerstone of pharmacological treatment, an increasingly relevant role is attributed to the inhibitors of the proprotein convertase subtilisin/kexin 9 (PCSK9i), as a result of the excellent results obtained in their respective trials, not only on the reduction of low-density lipoprotein (LDL) or LDL cholesterol (LDL-C) but also on plaque stabilization and regression. The addition of PCSK9 inhibitors leads to a further reduction in LDL levels and a consequent improvement in prognosis and it is recommended in ‘fast-track’ administration (intrahospital/discharge) in patients with acute coronary syndromes (ACSs) or multiple cardiovascular events already on statin therapy and LDL >70 mg/dL and in statin-naïve ACS patients and LDL >140 mg/dL. By applying guidelines and fast-track, ∼25% of patients with ACS should receive PCSK9i at discharge but unfortunately patients are currently undertreated.
Optimal prey for red fox cubs—An example of dual optimizing foraging strategy in foxes from a dynamic wetland habitat

Abstract The red fox (Vulpes vulpes) is the most abundant mesopredator in the Central European region. Detailed knowledge about their feeding behavior is important both from ecological and wildlife management reasons. Food choices of foxes are poorly predictable in high‐biodiversity marshlands. The main aim of our study was to sample parallel the main food‐type abundances in the study area and analyze the diet of fox cubs and cohabiting adults across 3 years during the period of maternal dependence of the cubs. According to the optimal foraging theory, we predicted that the cubs' diet would show higher energy content, would be more varied, and the individual prey species fed to the young would be larger. We analyzed the composition of adult fox and cub fecal samples collected separately around dens in a marshland of western Hungary, May 2014, 2017 and 2020, when the abundance values of main food sources differed. Rodents and waterfowl dominated the diet, but their relative occurrence in the samples showed yearly variations. We found that vixens follow a dual optimizing foraging strategy regarding their provisioning of the cubs and their own diet. Adult foxes optimized their diet according to the actual yearly abundances of their main food sources. Additionally, they preferred prey items that can be consumed at the site of capture (large carrion and small individual prey items). Cubs on the other hand were provisioned with optimal high‐energy food, even if those in question became less abundant in that year. Vixens mostly fed to their young either larger rodents and waterfowl, or multiple small rodents at a time—these type of prey are both optimal for transportation as a single load. Providing optimal prey at an early age in a changing environment may contribute to the ecological success of the red fox.
Gut microbiota and fecal short chain fatty acids differ with adiposity and country of origin: The METS-Microbiome Study

The relationship between gut microbiota, short chain fatty acid (SCFA) metabolism, and obesity is still not well understood. Here we investigated these associations in a large (n=1904) African origin cohort from Ghana, South Africa, Jamaica, Seychelles, and the US. Fecal microbiota diversity and SCFA concentration were greatest in Ghanaians, and lowest in the US population, representing the lowest and highest end of the epidemiologic transition spectrum, respectively. Obesity was significantly associated with a reduction in SCFA concentration, microbial diversity and SCFA synthesizing bacteria. Country of origin could be accurately predicted from the fecal microbiota (AUC=0.97), while the predictive accuracy for obesity was inversely correlated to the epidemiological transition, being greatest in Ghana (AUC = 0.57). The findings suggest that the microbiota differences between obesity and non-obesity may be larger in low-to-middle-income countries compared to high-income countries. Further investigation is needed to determine the factors driving this association.
Flux tube model for glueballs

We calculate the mass spectra and decay widths of glueballs in the flux tube model. The glueball is assumed to be a flux tube ring. The breathing and the rotational motions are investigated using the WKB approximation. The calculated spectrum is consistent with those obtained by lattice QCD. The decay widths are also computed using the Schwinger mechanism, and it is shown that they have rather large values. It is widely believed that the strong interaction is de- scribed by quantum chromodynamics ~QCD ! @ 1#. It is, how- ever, very difficult to solve QCD, so that several effective models have been devised to explain the physical properties of many hadrons. The flux tube model @2#, or hadron string model @3,4#, is one such model. According to this model, mesons are made up of a quark and antiquark connected by a color flux tube and baryons are described by a quark and diquark connected by the same flux tube. We showed in a previous paper @5# that various excited states of the hadrons can be explained systematically using such a simple model. On the other hand, recent lattice QCD simulations @6# predict the existence of glueballs, which are composed of only gluons. It is the purpose of this paper to present an intuitive and analytic approach to glueballs using a flux tube model. We assume that the glueball is a closed color flux tube ~flux tube ring ! Moreover, the flux tube that constitutes the ring is assumed to have the same properties as the flux tube that constitutes a meson or a baryon. Consequently, our model has no free parameter. We study the relativistic motion of the closed string and obtain the mass spectrum of the glueballs. This simple picture has already been considered by several authors. In particular, Koma, Suganuma, and Toki @7# studied the relativistic breathing motion analytically with the use of the dual Ginzburg-Landau theory @ 8-1 0#. We study not only the vibrational motion but also the rotational one. Moreover, the decay widths in @7# are also calculated by taking into account qqpair production inside the flux tube ~Schwinger mechanism! This paper is organized as follows. In the next section, the flux tube model for the glueballs is formulated. Section III is devoted to calculation of the mass spectra and the decay widths of the glueballs. In Sec. IV, the numerical results are presented and some discussion is given.
THE EFFECTS OF DIFFERENT CUMULUS PARAMETERIZATION SCHEMES IN WRF ON HEAVY RAINFALL IN HUNAN PROVINCE

A heavy rainfall during June 1—2,2007 in Hunan province was simulated using the weather research and forecast modeling system(WRF). The study was carried out with three cumulus parameterization schemes,Kain-Fritsch(KF),Betts-Miller-Janjic(BMJ) and Grell-Devenyi(GD),respectively.The project with Lin et al.’s microphysics and the three schemes above was involved in this study,together with a 20-km gridpoint resolution.The results indicated that the location of heavy rainfall areas roughly match the observation and better simulations are shown with the technique of 2-way gridpoint nesting than with the one without.By comparison,the KF scheme is closer to reality in location departure and intensity of heavy rainfall while the BMJ scheme reveals larger area and higher intensity but more southward location of the severe precipitation,though both of them give false centers of torrential rain;the intensity and area of heavy rainfall is weaker and smaller,respectively,for the GD scheme.
A Family of M*-Groups

A compact bordered Klein surface of (algebraic) genus g ≦ 2 is said to have maximal symmetry [5] if its automorphism group is of order 12(g – 1), the largest possible. An M*-group acts as the automorphism group of a bordered surface with maximal symmetry. M*-groups were first studied in [6], and additional results about these groups are in [5, 7, 8]. Here we construct a new, interesting family of M*-groups. Each group G in the family is an extension of a cyclic group by the automorphism group of a torus T with holes that has maximal symmetry. Furthermore, G acts on a bordered Klein surface X that is a fully wound covering [7] of T, that is, an especially nice covering in which X has the same number of boundary components as T. The construction we use for the new family of M*-groups is a standard one that employs group automorphisms to define extensions of groups.
Double Diffusive Natural Convection in a Porous Rhombic Annulus

This article reports on an investigation performed to study laminar steady state double diffusive natural convection in a two-dimensional porous enclosure of rhombic cross-section. Solutions are obtained numerically using a finite volume method for the case when the inner wall is uniformly heated to a temperature T h while subjected to a high solute concentration S h , and the outer wall is evenly cooled to a temperature T c while exposed to a low solute concentration S c . Simulations are conducted for several values of Rayleigh number (Ra), Darcy number (Da), Prandtl number (Pr), porosity (ϵ), and enclosure gap (E g ) for fixed values of Lewis number (Le = 10) and buoyancy ratio (N = 10). The results are displayed in terms of streamlines, isotherms, isoconcentrations, mid-height velocity, temperature, concentration profiles, and local and average Nusselt and Sherwood number values. Predictions indicate that for the Lewis number and buoyancy ratio considered, the flow field is more affected by mass transfer than by heat transfer. Moreover, convection effects increase with an increase in Ra, Da, E g , and/or ϵ. The porosity of the porous matrix has no effect on the flow, temperature, and concentration fields at low values of Darcy number. Furthermore, the total heat and mass transfer increases as Pr increases and/or as the enclosure gap decreases due to an increase in the wall area over which heat and mass transfer occur. Values of and indicate dominant diffusion at low Ra number values with convection affecting the total heat and mass transfer at high Ra values.
EXOSOMES AND MICROVESICLES FROM ADIPOSE-DERIVED MESENCHYMAL STEM CELLS PROTECTS THE ENDOTHELIAL GLYCOCALYX FROM LPS INJURY

ABSTRACT Introduction: Endothelial glycocalyx damage occurs in numerous pathological conditions and results in endotheliopathy. Extracellular vesicles, including exosomes and microvesicles, isolated from adipose-derived mesenchymal stem cells (ASCs) have therapeutic potential in multiple disease states; however, their role in preventing glycocalyx shedding has not been defined. We hypothesized that ASC-derived exosomes and microvesicles would protect the endothelial glycocalyx from damage by LPS injury in cultured endothelial cells. Methods: Exosomes and microvesicles were collected from ASC conditioned media by centrifugation (10,000g for microvesicles, 100,000g for exosomes). Human umbilical vein endothelial cells (HUVECs) were exposed to 1 μg/mL lipopolysaccharide (LPS). LPS-injured cells (n = 578) were compared with HUVECS with concomitant LPS injury plus 1.0 μg/mL of exosomes (n = 540) or microvesicles (n = 510) for 24 hours. These two cohorts were compared with control HUVECs that received phosphate-buffered saline only (n = 786) and HUVECs exposed to exosomes (n = 505) or microvesicles (n = 500) alone. Cells were fixed and stained with FITC-labeled wheat germ agglutinin to quantify EGX. Real-time quantitative reverse-transcription polymerase chain reaction was used on HUVECs cell lystate to quantify hyaluron synthase-1 (HAS1) expression. Results: Exosomes alone decreased endothelial glycocalyx staining intensity when compared with control (4.94 vs. 6.41 AU, P < 0.001), while microvesicles did not cause a change glycocalyx staining intensity (6.39 vs. 6.41, P = 0.99). LPS injury resulted in decreased glycocalyx intensity as compared with control (5.60 vs. 6.41, P < 0.001). Exosomes (6.85 vs. 5.60, P < 0.001) and microvesicles (6.35 vs. 5.60, P < 0.001) preserved endothelial glycocalyx staining intensity after LPS injury. HAS1 levels were found to be higher in the exosome (1.14 vs. 3.67 RE, P = 0.02) and microvesicle groups (1.14 vs. 3.59 RE, P = 0.02) when compared with LPS injury. Hyaluron synthase-2 and synthase-3 expressions were not different in the various experimental groups. Conclusions: Exosomes alone can damage the endothelial glycocalyx. However, in the presence of LPS injury, both exosomes and microvesicles protect the glycocalyx layer. This effect seems to be mediated by HAS1. Level of Evidence: Basic science study
Perceptual History Biases Are Predicted by Early Visual-Evoked Activity

What we see in the present is affected by what we saw in the recent past. Serial dependence, a bias making a current stimulus appear more similar to a previous one, has been indeed shown to be ubiquitous in vision. At the neural level, serial dependence is accompanied by a signature of stimulus history (i.e., past stimulus information) emerging from early visual-evoked activity. However, whether this neural signature effectively reflects the behavioral bias is unclear. Here we address this question by assessing the neural (electrophysiological) and behavioral signature of stimulus history in human subjects (both male and female), in the context of numerosity, duration, and size perception. First, our results show that while the behavioral effect is task-dependent, its neural signature also reflects task-irrelevant dimensions of a past stimulus, suggesting a partial dissociation between the mechanisms mediating the encoding of stimulus history and the behavioral bias itself. Second, we show that performing a task is not a necessary condition to observe the neural signature of stimulus history, but that in the presence of an active task such a signature is significantly amplified. Finally, and more importantly, we show that the pattern of brain activity in a relatively early latency window (starting at ∼35-65 ms after stimulus onset) significantly predicts the behavioral effect. Overall, our results thus demonstrate that the encoding of past stimulus information in neural signals does indeed reflect serial dependence, and that serial dependence occurs at a relatively early level of visual processing. SIGNIFICANCE STATEMENT What we perceive is determined not only by the information reaching our sensory organs, but also by the context in which the information is embedded. What we saw in the recent past (perceptual history) can indeed modulate the perception of a current stimulus in an attractive way, a bias that is ubiquitous in vision. Here we show that this bias can be predicted by the pattern of brain activity reflecting the encoding of past stimulus information, very early after the onset of a stimulus. This in turn suggests that the integration of past and present sensory information mediating the attractive bias occurs early in the visual processing stream, and likely involves early visual cortices.
Nurses' second victim experience, job insecurity, and turnover intention: A latent profile analysis.

Nurses are greatly affected by patient safety incidents, but little is known about the classifications of nurses' second victim experiences and their effects on job insecurity and turnover intention. This study aimed to identify the profiles of nurses' second victim experiences, including perceived support and distress, and explore the effects of the different experiences on nurses' job insecurity and turnover intention. A convenience sample of 2000 nurses, who were directly involved in patient safety incidents within a year at 25 hospitals in 13 provinces in China, was invited to participate. The online surveys included the Second Victim Experience and Support Tool-Chinese version, job insecurity scale, and turnover intention scale. Data were analyzed using regression and latent profile analysis to identify second-victim nurses' different experience predictors and examine the relationships among the factors. A total of 1298 valid questionnaires were obtained. Three profiles of second victim experiences were identified. Univariate analysis demonstrated that nurses' experience, education level, hospital type, specialty, working hours, credentials, clinical ladder, type of employment, income, training on adverse events, and the type of adverse event were statistically significant (p < 0.05) variables differentiating the three profiles. After controlling these significant variables, the multiple regression analysis showed that the higher the support and the lower the distress level of the second victim, the lower the job insecurity and turnover intention. This study highlights the significance of nurse' leader and organizational support. Nursing leaders should recognize nurses' second-victim experiences, provide the support nurses need, and help them reduce job insecurity and turnover intention.
Impact of Teeth on Social Participation: Modified Treatment Policy Approach

Social participation prevents social isolation and loneliness among older adults while having numerous positive effects on their health and well-being in rapidly aging societies. We aimed to estimate the effect of retaining more natural teeth on social participation among older adults in Japan. The analysis used longitudinal data from 24,872 participants in the Japan Gerontological Evaluation Study (2010, 2013, and 2016). We employed a longitudinal modified treatment policy approach to determine the effect of several hypothetical scenarios (preventive scenarios and tooth loss scenarios) on frequent social participation (1 = at least once a week/0 = less than once a week) after a 6-y follow-up. The corresponding statistical parameters were estimated using targeted minimum loss-based estimation (TMLE) method. Number of teeth category (edentate/1–9/10–19/≥20) was treated as a time-varying exposure, and the outcome estimates were adjusted for time-varying (income, self-rated health, marital status, instrumental activities of daily living, vision loss, hearing loss, major comorbidities, and number of household members) and time-invariant covariates (age, sex, education, baseline social participation). Less frequent social participation was associated with older age, male sex, lower income, low educational attainment, and poor self-rated health at the baseline. Social participation improved when tooth loss prevention scenarios were emulated. The best preventive scenario (i.e., maintaining ≥20 teeth among each participant) improved social participation by 8% (risk ratio [RR] = 1.08; 95% confidence interval [CI], 1.05–1.11). Emulated tooth loss scenarios gradually decreased social participation. A hypothetical scenario in which all the participants were edentate throughout the follow-up period resulted in a 11% (RR = 0.89; 95% CI, 0.84–0.94) reduction in social participation. Subsequent tooth loss scenarios showed 8% (RR = 0.92; 95% CI, 0.88–0.95), 6% (RR = 0.94; 95% CI, 0.91–0.97), and 4% (RR = 0.96; 95% CI, 0.93–0.98) reductions, respectively. Thus, among Japanese older adults, retaining a higher number of teeth positively affects their social participation, whereas being edentate or having a relatively lower number of teeth negatively affects their social participation.
Pathogenic LRRK2 compromises the subcellular distribution of lysosomes in a Rab12‐RILPL1‐dependent manner

Mutations in leucine‐rich repeat kinase 2 (LRRK2) cause familial Parkinson's disease (PD). Recent studies have shown that LRRK2 physiologically phosphorylates several Rab family proteins including Rab12 and that this phosphorylation is accelerated by the pathogenic mutations in LRRK2, although the significance in the PD pathogenesis remains unknown. Here we examined the effect of the overexpression of LRRK2 on the distribution of organelles in cultured cells and found that lysosomes become clustered in a perinuclear region upon the overexpression of pathogenic mutant LRRK2 in a manner dependent on its kinase activity. The perinuclear clustering of lysosomes was abolished by knocking out RAB12 as well as its effector protein RILPL1. Re‐expression of Rab12 in RAB12 knockout cells suggested that the phosphorylation at Ser106 of Rab12 is required for the perinuclear clustering of lysosomes. Moreover, phosphorylated Rab12 was also accumulated on the clustered lysosomes, and the phosphorylation of Rab12 increased its interaction with RILPL1, leading us to conclude that the increase in the phosphorylation of Rab12 by pathogenic LRRK2 compromised intracellular lysosomal transport via the enhanced interaction of Rab12 with RILPL1. These data suggest the involvement of abnormal regulation of lysosomal transport in the LRRK2‐mediated pathogenesis of PD.