Miracle-dz/UniFAR-FTUs huggingface dataset:
Chronic Colitis by Neutrophils Isolated from Mice with Acquisition of Antigen-Presenting Functions

Active episodes of the inﬂammatory bowel diseases are associated with the inﬁltration of large numbers of myeloid cells including neutrophils, monocytes, and macrophages. The objective of this study was to systematically characterize and deﬁne the different populations of myeloid cells generated in a mouse model of chronic gut inﬂammation. Using the T cell transfer model of chronic colitis, we found that induction of disease was associated with enhanced production of myelopoietic cytokines (IL-17 and G-CSF), increased production of neutrophils and monocytes, and inﬁltration of large numbers of myeloid cells into the mesenteric lymph nodes (MLNs) and colon. Detailed characterization of these myeloid cells revealed three major populations including Mac-1 + Ly6C high Gr-1 low/neg cells (monocytes), Mac-1 + Ly6C int Gr-1 + cells (neutrophils), and Mac-1 + Ly6C low/neg Gr-1 low/neg leukocytes (mac-rophages, dendritic cells, and eosinophils). In addition, we observed enhanced surface expression of MHC class II and CD86 on neutrophils isolated from the inﬂamed colon when compared with neutrophils obtained from the blood, the MLNs, and the spleen of colitic mice. Furthermore, we found that colonic neutrophils had acquired APC function that enabled these granulocytes to induce proliferation of OVA-speciﬁc CD4 + T cells in an Ag- and MHC class II-dependent manner. Finally, we observed a syner-gistic increase in proinﬂammatory cytokine and chemokine production following coculture of T cells with neutrophils in vitro. Taken together, our data suggest that extravasated neutrophils
Evaluation of a training program for soft skill education and nancial literacy to community health workers in India: a quasi-experimental study

shantanu sharma (  shantanusharma145@gmail.com ) Lund University https://orcid.org/0000-0002-5064-4782 Kanishtha Arora MAMTA Health Institute for Mother and Child Chandrashekhar Chandrashekhar MAMTA Health Institute for Mother and Child Rajesh Kumar Sinha MAMTA Health Institute for Mother and Child Faiyaz Akhtar MAMTA Health Institute for Mother and Child Sunil Mehra MAMTA Health Institute for Mother and Child
Voltage stability via energy function analysis on reduced order model of power system

A power system is a typical nonlinear dynamical system and voltage stability is an important subject of power system stability. This paper describes the use of the variable gradient method in a reduced order model of a single-machine infinite-bus power system. Additionally, the system's Lyapunov (energy) function is created and thus the system's energy level changes' effects on the system's stability are shown using the MACSYMA program. The Lyapunov function allows the determination of stability for nonlinear systems without the need to find exact solutions.
PROFILE OF CHILDREN PRESENTS WITH TETANUS AT SERVICES HOSPITAL LAHORE

: Background: Tetanus is an important cause of morbidity and mortality in developing countries though it is rare in developed countries. Childhood tetanus has high mortality and is preventable. Knowledge about the need of active and passive immunization for wound is still not encouraging. This study was conducted to describe the clinical profile, management outcome and prognostic indicators of tetanus in children in our region. Methodology: It is a cross sectional study. This study was conducted at pediatric ward, Services Hospital Lahore from September 2017 to February 2018. In this study 100 patients were included. Their parents were interviewed according to the given performa. Results: Out of these patients, the fathers of 68 patients and mothers of 86 patients were either illiterate or primary education only. Most 56 of the patients belonged to a low socioeconomic family having the monthly income of less than PKR 10,000. The fathers of 42 patients were Saraiki. 57 patients were from rural areas. Out of 100 affected, seventy percent of patients were boys, age range of 5 to 10 years. Conclusion: Tetanus is a preventable disease and to prevent it, more awareness in the society is needed. The various factors which are responsible for the development of childhood tetanus were; poor educational status of the parents, ethnicity, low socioeconomic status and people from rural areas.
Identi cation of the Key Serum Biomarkers to Diagnose and Predict Metastasis of Osteosarcoma Based on the Analysis of Immune Cell In ltration Characteristics

Zhihao Chen Second A liated Hospital of Soochow University Liubing Li Second A liated Hospital of Soochow University Ziyuan Li Second A liated Hospital of Soochow University Xi Wang Second A liated Hospital of Soochow University Mingxiao Han Second A liated Hospital of Soochow University Zongshuai Gao Shanghai Jiao Tong University A liated Sixth People's Hospital Min Wang Second A liated Hospital of Soochow University Gangfeng Hu Second A liated Hospital of Soochow University Xiaolu Xie Second A liated Hospital of Soochow University Hong Du Second A liated Hospital of Soochow University Zonggang Xie Second A liated Hospital of Soochow University Haifang Zhang (  haifangzhang@suda.edu.cn ) Second A liated Hospital of Soochow University https://orcid.org/0000-0001-6434-3561
Integrin, 2 b Eosinophils Mediated by a Innate Antifungal Immunity of Human

Eosinophils produce and release various proinﬂammatory mediators and also show immunomodulatory and tissue remodeling functions; thus, eosinophils may be involved in the pathophysiology of asthma and other eosinophilic disorders as well as host defense. Several major questions still remain. For example, how do human eosinophils become activated in diseased tissues or at the site of an immune response? What types of host immunity might potentially involve eosinophils? Herein, we found that human eosinophils react vigorously to a common environmental fungus, Alternaria alternata , which is implicated in the development and/or exacerbation of human asthma. Eosinophils release their cytotoxic granule proteins, such as eosinophil-derived neurotoxin and major basic protein, into the extracellular milieu and onto the surface of fungal organisms and kill the fungus in a contact-dependent manner. Eosinophils use their versatile (cid:1) 2 integrin molecule, CD11b, to adhere to a major cell wall component, (cid:1) -glucan, but eosinophils do not express other common fungal receptors, such as dectin-1 and lactosylceramide. The I-domain of CD11b is distinctively involved in the eosinophils’ interaction with (cid:1) -glucan. Eosinophils do not react with another fungal cell wall component, chitin. Because human eosinophils respond to and kill certain fungal organisms, our ﬁndings identify a previously unrecognized innate immune function for eosinophils. This immune response by eosinophils may beneﬁt the host, but, in turn, it may also play a role in the development and/or exacerbation of eosinophil-related allergic human diseases, such as asthma. The Journal of Immunology, 2008, To examine whether physical contact between A. alternata and eosin- ophils is necessary to activate eosinophils, 24-well Transwell inserts (pore size 0.4 (cid:2) m; Costar) were used to prevent contact between A. alternata and eosinophils. In other experiments, eosinophils were incubated with supernatants from cultured A. alternata . To examine whether eosinophils re- spond to fungal cell wall components, serial dilutions of (cid:1) -glucan particles (Curdlan) or chitin particles (cid:2) g/ml) were used as stimuli. To examine the involvement of a (cid:1) 2 integrin, CD11b, in eosinophil activation
Utilisation des céramiques biphasées dans les pertes de substance osseuse de

Management of bone loss in revision total hip replacement remains a challenge. To eliminate any immunological or infectious problem and so to try to improve the long-term results obtained with allografts, the authors used synthetic ceramics as bone substitutes since 1995. We reviewed 13 of the patients of our study, we previously reported in 2005 (Schwartz and Bordei in Eur J Orthop Surg Traumatol 15: 191 2005), which was a pro-spective cohort of thirty-two cases of acetabular revision reconstruction, with a mean follow-up of 14.4 years yet (from 9 to 16 years). Clinical results were assessed according to Oxford scale and Postel and Merle d’Aubigne (PMA) scale. Since 2005, no speciﬁc complications were noted. The average PMA functional hip score was 14.9 (vs. 9.2 before revision) at follow-up over 9 years. Nine patients still alive in 2013 were seen again by a surgeon, which was not the operator, with a mean follow-up of 15.3 years: Their Oxford average score was 40.3. Radiological assessment afﬁrmed a good integration of the substitutes in bone without any edging in all cases. A progressive invasion of the ceramics by bone can be seen on the X-ray. We conclude that about 15 years of average delay, which is a signiﬁcant follow-up in orthopedic surgery, the outcomes without speciﬁc complications are satisfactory and allow one to go with these materials in total hip revision surgery.
Exploring the in uence of the North Paci c Ocean Rossby wave sources on interannual variability of summer precipitation and surface temperature over the Northern Hemisphere

Ramon Fuentes-Franco (  ramon.fuentesfranco@smhi.se ) SMHI https://orcid.org/0000-0002-3085-0175 Torben Koenigk SMHI: Sveriges meteorologiska och hydrologiska institut David Docquier SMHI: Sveriges meteorologiska och hydrologiska institut Federico Graef CICESE: Centro de Investigacion Cienti ca y de Educacion Superior de Ensenada Klaus Wyser SMHI: Sveriges meteorologiska och hydrologiska institut
The impact of corporate governance provisions on R&D intensity: a closer look at corporate governance in an international perspective

: Using panel data analysis, this paper considers the impact of governance provisions on firm’s R&D investment decisions. The current paper also contributes to the literature on corporate governance and innovation by introducing an interaction dimension which captures the influence that internationalization of U.S. firms may have on R&D investment decisions. Based on a sample of 627 U.S. firms for the years 2008-2016 this paper’s results suggest that governance provisions do not nurture or impede R&D investments, and therefore the results casts doubt on the existence of a relationship between governance provisions and R&D intensity. The current paper’s findings also suggest that proposed effects of internationalization do not modify the relationship between entrenchment and R&D for U.S. firms. this study: What effect do governance provisions have on investments in innovation, and is this effect moderated by firm internationalization?
THE NEURAL CORRELATES OF INTERNET ADDICTION

In everyday life, people are interacting with the Internet. The emergence of this phenomenon has been positively contributing to the rapid development of our society in the last decades. However, negative reports about excessive usage are coming to the surface and questions about potential negative consequences are being raised. Internet addiction (IA) has been suggested as a new type of disorder. There is a new field of research emerging with the aim to investigate its nature. This review compiles the most relevant literature on neuroimaging techniques used to identify the underlying neurobiological mechanisms of IA. Based on identified comorbidity between IA and attention-deficit hyperactivity disorder (ADHD), a comparison between the neural correlates of IA and ADHD is attempted, in order to illustrate the importance of bringing more attention to IA. The findings present structural, functional and neurochemical alterations in brain regions associated with emotional processing, cognitive control and reward processing. Similarities between the two disorders in terms of structural and functional alterations in regions associated with emotional processing and cognitive control are highlighted. Limitations regarding lack of consensus of the operational definition, narrow selection criteria of participants and a need for subcategories inside the term IA are pointed out. The thesis concludes that as of now the discovered alterations may be considered as biological markers underlying the disorder and IA is a field of research worthy of more attention.
Signiﬁcance of the incoherent interface for modelling of 1 the olivine–spinel transformation 2

6 We compare two models of growth of a rim of high–pressure phase on a sphere which is initially at uniform pressure p 0 , and whose surface is kept at that pressure. The models share these features: the same thermodynamic potential is used to describe the eﬀect of strain energy on interface kinetics; stress– free strain enters only into the relation between pressure within an element of product phase, and the volume strain experienced by it from its initial state as parent phase; at the interface, the normal component of displacement is continuous, and the shear stress vanishes. The models diﬀer in one respect. In one, deviatoric stress within an element of product is determined by the total deviatoric strain from the initial state. In the other, deviatoric stress is determined by the increment in deviatoric strain subsequent to transformation; memory of prior deviatoric strain is erased within the incoherent interface as the lattice is rebuilt. The ﬁrst model is not consistent with experiments on the olivine–ringwoodite transformation in single crystals: it predicts that samples should have transformed completely at a roughly constant rate; instead, growth slowed, and may even have ceased. The second model predicts this behaviour: evem with purely elastic deformation, theory and experiment agree adequately for samples having 75–200 ppmw of water. For nominally anhydrous samples, rims are thinner than predicted. As creep is not essential to this model, these very thin rims suggest water may be essential to lattice reconstruction.
O ct 2 00 3 CERN-TH / 2003-172 , HD-THEP-03-38 , UFIFT-HEP-0320 Dynamics of super-horizon photons during inflation with vacuum polarization

We study asymptotic dynamics of photons propagating in the polarized vacuum of a locally de Sitter Universe. The origin of the vacuum polarization is fluctuations of a massless, minimally coupled, scalar, which we model by the one-loop vacuum polarization tensor of scalar electrodynamics. We show that late time dynamics of the electric field on superhorizon scales approaches that of an Airy oscillator. The magnetic field amplitude, on the other hand, asymptotically approaches a nonvanishing constant (plus an exponentially small oscillatory component), which is suppressed with respect to the initial (vacuum) amplitude. This implies that the asymptotic photon dynamics is more intricate than that of a massive photon obeying the local Proca equation.
T HE S EMANTICS OF R ISING I NTONATION IN I NTERROGATIVES AND D ECLARATIVES ∗

We analyze rising declaratives in English as modal expressions of epistemic uncertainty and argue that their question-like behavior is a secondary effect derived from maxims of rational conversation. In order to express the meaning with formal semantics, we combine Veltman’s update semantics with the test operator with a simple semantics for polar questions.
Interest Rates, Moneyness, and the Fisher Equation

——————————————————————————————————— The Euler equation of a representative consumer – or its long-run counterpart, the Fisher equation – is at the heart of modern macroeconomics. But in empirical applications, it is badly misapplied: it prices a bond that is short-term, perfectly safe, yet perfectly illiquid. Such a bond does not exist. Real-world safe assets are highly tradable or pledgeable as collateral, hence their prices reﬂect their moneyness as much as their dividends. Indeed, I estimate the return on a hypothetical illiquid bond, for the postwar United States, via inﬂation and consumption growth, and show that it behaves very differently from the return on safe and liquid assets. I also argue that this distinction helps resolve a great number of puzzles associated with the Euler/Fisher equation, and points to a better way of understanding how monetary policy affects the economy. —————————————————————————————————————————
Timescales and functional organization of neural event segmentation in the human brain

During continuous perception, humans automatically segment their experience into discrete events. At the neural level, each brain region is thought to segment ongoing experience at its own preferred timescale. Previous studies have shown that event segmentation follows a temporal hierarchy in the brain, with regions higher in the hierarchy segmenting experience into events with a longer duration. The assumption is that incoming information is processed and then passed on to higher order regions as discrete units (or chunks), but little is known about how event boundaries are shared both within and across networks. To this end, we use Hidden Markov Models (HMMs) and functional connectivity analysis to study the timescales of event segmentation over the entire cortex and investigate how event boundaries are shared across regions and networks. We demonstrate that there is a distinct temporal gradient of information processing over the entire cortex, with particularly fast events in primary sensory regions and long periods of information integration in the precuneus and medial prefrontal cortex. We also show that event boundaries are shared between regions within functional networks, as well as across the temporal hierarchy between distinct networks. Finally, we observed that the traditional default mode and fronto-parietal networks fractionate into subnetworks with fast and slow event timescales, possibly reflecting functional specialization within these networks during naturalistic viewing. Together, these results provide the first complete overview of how event segmentation is organized in the human brain.
THE IMPORTANCE OF DESIGN DIARIES IN THE INTRODUCTORY COURSE OF ARCHITECTURAL DESIGN

Summary: The research presented in this paper is a segment of a broader study that examined the application of diagrams in the process of the architectural design of students. Design diaries (sketch maps) were used to record this process, and the focus of the present paper is on the role and importance of these diaries for the development of design skills of beginners in the introductory studio course. The results of the research show that design diaries enable the organization of ideas over time, which facilitates the synthesis of ideas and inspiration.
Two-degree-of-freedom vortex-induced vibration of a pivoted cylinder below critical mass ratio

In this study, we investigated two-degree-of-freedom (2d.f.) vortex-induced vibrations (VIVs) of a circular cylinder with a pinned attachment at its base; it had identical mass ratios and natural frequencies in both streamwise and transverse directions. The cylinder had a mass ratio, m (cid:1) of 0.45, and a mass damping, ( m (cid:1) C C A ) z , equal to 0.0841. Laser-induced ﬂuorescence ﬂow visualization and digital particle image velocimetry experiments were conducted over a Reynolds number range, 820 % Re % 6050 (corresponding to the reduced velocity range, 1.1 % U (cid:1) % 8.3). Measurements and visualization studies were made in a ﬁxed plane at the cylinder mid-height, providing a two-dimensional picture of a highly three-dimensional system. However, signiﬁcant insights can be gained from these experiments and form the basis of this paper. A large transverse amplitude response, A (cid:1) Y w 2 (or four diameters peak-to-peak), in the upper branch was observed. The streamwise amplitude response exhibits an even higher peak amplitude, A (cid:1) X w 2 : 5, which is approximately 125% of peak A (cid:1) Y . Results show that there is no lower branch for this system and the transverse upper branch exhibits asymptotic behaviour, i.e. a wide regime of resonance. For Re O 3000, the Strouhal number for the vortex shedding was 0.16 ( G 9%). Both the transverse cylinder oscillation and vortex-shedding frequencies, f OS, Y and f VS , respectively, were virtually identical throughout this range. While the streamwise oscillation frequency is typically twice the transverse oscillation frequency for a 2d.f. system, this is not the case at the lowest reduced velocities where oscillations ﬁrst occur. conditions the streamwise and transverse oscillation frequencies were identical. Finally, we observed that the cylinder wake exhibits both the P C S vortex-shedding mode and a desynchronized vortex pattern, which are uncommon for ﬂow past a cylinder experiment. Very interestingly, the wide U (cid:1) range over which resonance occurs is dominated by a desynchronized vortex pattern. These results clearly demonstrate the differences that arise in 2d.f. VIV occurring below the critical mass ratio.
The transition between lit and unlit sections of road and detection of driving hazards after dark

An experiment to investigate peripheral detection performance during a driver’s transition between lit and unlit sections of road was undertaken. The results suggest that when a driver moves from a lit to an unlit section of road their detection performance decreases almost immediately to that expected for the conditions of the unlit section and that there is no significant change in the subsequent 20-minute period. Tests were conducted at three luminances (0.1, 1.0 and 2.0 cd/m2): while an increase from 0.1 to 1.0 cd/m2 improved detection, a further increase to 2.0 cd/m2 did not. Lighting of two S/P ratios (0.65, 1.40) was examined at 1.0 cd/m2: this did not suggest an effect on detection performance. Taken together, these results suggest that, in the current context, visual performance reached a plateau at 1.0 cd/m2.
OPTH_A_255626 1495..1501

Ophthalmology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt Purpose: Pseudophakic glaucoma is a secondary glaucoma in which intra-ocular pressure is elevated following cataract removal. The current study aimed to evaluate the role of ultrasound biomicroscopy (UBM) in assessing post-operative pseudophakic glaucoma. Patients and Methods: This is a case series, prospective, observational and analytical study. It included 29 eyes of 29 patients with post-operative pseudophakic glaucoma. The patients were evaluated by medical history, detailed ophthalmologic examination and UBM. Results: UBM examination has unmasked different causes of pseudophakic glaucoma. The detected causes were classified into 3 main groups, including intraocular lens (IOL)-related causes, lens remnants and intra-ocular inflammation. Haptic-related causes were present in 9 eyes, while 6 eyes had decentered or tilted IOLs. Soemmering’s ring was the main cause in 3 eyes while in one eye the cause was lens particle in the anterior chamber (AC). Silicone oil in AC with seclusio pupillae was the main cause in one eye. Peripheral anterior synechiae were detected in 8 eyes while, posterior synechiae were evident in 7 eyes. Uveitis induced by anterior chamber IOL (ACIOL) was found in 3 eyes and one eye had peripheral anterior synechiae due to neovascular glaucoma. Conclusion: UBM is a helpful diagnostic tool to evaluate causes of pseudophakic glaucoma through adequate visualization of different angle structures.
Performance improvements in hospitals after implementing Business Intelligence software

In a case study of four Dutch hospitals the impact of successfully implemented Business Intelligence software is examined. This is done by using the DeLone & McLean model for Management Information System success and the Elbashir et al. method for measuring benefits of Business Intelligence software. Based on the responses of the Business Intelligence manager and several operational managers of the hospitals it can be concluded that successfully implemented Business Intelligence has a significant positive impact on the operational success of hospitals.