Miracle-dz/UniFAR-FTUs huggingface dataset:
International Journal of Applied Sciences and Biotechnology

Free radicals include both Reactive Oxygen Species (ROS) and Reactive Nitrogen Species (RNS). When free radicals are produced in a regulated manner in a healthy human body it is scavenged efficiently by antioxidant defense system. But excess generation of pro-oxidants by continuous chain reaction in the form of ROS and RNS cause several human diseases. The shift of the balance in the favour of pro-oxidants results in a condition called “oxidative stress”. Alcohol is primarily metabolized in the liver to generate ROS and RNS, leading to diseases such as cirrhosis, fatty liver and chronic hepatitis. Alcohol induced damage is associated with oxidative stress. The excess generation of prooxidants and reduced antioxidant levels provide an effective model of Hepatotoxicity which is noteworthy. Recent trend is to discover polyherbal formulation of medicinal plants which have hepatoprotective function. In the present study 80% alcoholic extract of leaves of Aloe vera, Bacopa monniera, Moringa oleifera and rhizome of Zingiber officinale were utilized to prepare Herbal Preparation or HP-4.Further the hepatoprotective effects of HP-4 was tested in alcohol induced Hepatotoxicity in mice. Silymarin is a well known hepatoprotective drug was used as a standard for comparison. Biochemical and histopathological studies provided ample evidence that HP-4 provided a hepatoprotective role in alcohol induced hepatotoxicity which was comparable to drug Silymarin. The presence of phytochemicals in HP-4 provided a synergistic, supra-additive and co-operative effects in the hepatoprotective function in alcohol induced hepatotoxicity mice model.
Investigation on the Onset of Gas Entrainment by Experimental Simulation of Two Side Branches of PHWR Header Using Air and Water-IJAERD

Abstract-An experimental investigation has been conducted to determine the vortex free critical height during single discharge and dual discharge from the smooth stratified air-water region through side branches mounted on a circular surface. The branches are of 9 mm internal diameter and oriented at 0 0 and 180 0 . The experimental data are generated for branch Froude number in the range of 6.4 to 27.5. Both the branches are kept at equal Froude number. The results are compared with existing empirical and theoretical correlations. Experimental based correlations are developed relating critical height, branch diameter and Froude number.
DUST EXPOSURE AND RESPIRATORY HEALTH SYMPTOMS AMONG WORKERS IN SMALL SCALE SUNFLOWER OIL INDUSTRY IN SINGIDA TANZANIA

Background: Small scale sunflower oil industries are industries which extract oil from sunflower seed. Apart from its contribution to the economic development of the nation, during extraction process much dust concentration produced and respiratory symptoms are unknown. The aim of study was to assess dust exposure and associated respiratory health symptoms among small scale sunflower oil industries workers in Singida Tanzania. Methods: A cross sectional study was conducted and 233 participants were interviewed using a modified American Thoracic Society questionnaire to assess the respiratory health symptoms. A Side Kick Casella Pump was used to collect respirable dust from a sub sample of 66 workers from the sieving section. Results: Respirable dust exposure levels for mean, and Geometrical mean was 10.45 mg/m3 (SD 13.90) and GM=5.25 mg/m3 (GSD 0.51) respectively, and 46% of the dust samples (n=66) were above the TLV of 5 mg/m3. Logistic regression analysis between measured dust and respiratory symptoms found to be statistically significant. Higher prevalence of respiratory health symptoms were seen in those with cough (33%), cough with phlegm (46.8%) and wheezy (41.6%). Conclusion: The study concludes that, respiratory symptoms were high and dust exposure was above recommended levels of 5 mg/m3. We recommend use of appropriate RPE.
Effect of Point of Sales (POS) Utilization on Effective Demand for Agricultural Commodities in Stores and Supermarket in Akure Metropolis, Ondo State, Nigeria

Point of Sales (POS) was one of the promising epayment methods introduced by the monetary regulatory body (CBN) in Nigeria, following its capability of curbing many challenges of financial bodies and the economy. The purpose of this study was to determine the effect of point of sales (POS) utilization on effective demand for agricultural commodities in stores and supermarket in Akure Metropolis. Multistage sampling procedure was used in selecting one hundred and sixty (160) consumers paying for agro-commodities through POS for the study. Data were collected through the use of structured interview schedule and were analyzed using descriptive statistics and regression. The study identified convenience as the main reason for utilizing POS and also found sex, age, household size, monthly income and effect of POS as factors influencing effective demand of agro-commodities using the POS. The study however concludes that the use of POS increases the demand for agro commodities.
Aconitine poisoning and its effects on various systems-A review

Herbal medicines are commonly used as alternative medicines in Asian countries, more in China, to treat various diseases due to its natural, harmless, and less adverse effects for thousands of years. Aconitum plants have been extensively applied to treat multiple diseases in China and some other Asian countries. Traditional Chinese medicines are processed by soaking or boiling before consumption to reduce the toxicity. [3,4] In general, herbal poisoning may frequently occur due to inadequate processing and preparation, overdose, contamination, misidentification, and even in some suicidal or homicidal cases. However, it is difficult for forensic experts to find the specific results in present forensic autopsy of aconitine-induced death. [1,2,5]
Evaluation Outcome of the Regional Approach of Physiotherapy, Conventional Approach of Physiotherapy and Non-Steroidal Anti-Inflammatory Drugs (NSAID) on Pain and Disability for Chronic Mechanical Spinal Pain Disorder-A Repeated Measure Clinical Trial Design

Introduction: Physiotherapy approaches for ensuring a comprehensive clinical outcome are attaining growing concentration among physiotherapists treating spinal pain disorder (SPD). The purpose of the study is to compare effectiveness of the regional approach (new approach) of physiotherapy treatment, NSAID and conventional physiotherapy approach on pain and disability status for chronic mechanical spinal pain disorder. Materials and Method: A repeated measurement ANOVA clinical trial design was carried out to test the hypothesis. 104 patients between 20 65 years old with chronic mechanical spinal pain were randomly assigned into 3 different groups. Measurements were taken before starting of intervention, middle of the intervention and at the end of the intervention. The regional group (30 patients) received 8 sessions of regional approach of Physiotherapy, conventional group (35 patients) received 8 sessions of conventional approach of physiotherapy treatment and drug group (39 patients) received 21 to 30 days NSAID as per prescription of an orthopedic Professor. To eliminate bias, clinical physiotherapists were also randomly allocated into either for regional approach physiotherapy group or as usual physiotherapy group. A treatment protocol of regional approach was developed and handed over to clinical physiotherapists for regional approach group to deliver treatment. Outcomes were monitored by Numeric Pain Rating Scale and Oswestry Disability Index (ODI)/Neck Disability Index (NDI). Results: The results of the study show that the regional approach of physiotherapy treatment, NSAID and conventional physiotherapy approach are differentially effective on pain and disability status (P < 0.05). The outcomes of pain and disability status are differently effective over different occasions of treatment (pretest, mid-test and posttest) for chronic mechanical spinal pain (P < 0.05). Although the effect of time and treatment interaction on pain was not found to be statistically significant but disability status was shown to be statistically significant (P < 0.05). Greater improvement (on pain and disability) has been shown in regional group in comparison to conventional and NSAID group. Conclusion: Regional approach of treatment has been found to be a new evidence of treatment for chronic mechanical spinal pain which also indicate that chronic pain is multi-structural phenomena and therefore physiotherapy treatment should cover regionally. The study demonstrates short term outcome of the treatment methods. However, a further study is required to see the long term effect of those treatments.
The association of serum osteoprotegerin/ sRANKL complex, C-reactive protein and adiponectin with number of circulating endothelial progenitor cells in patients with metabolic syndrome and diabetes mellitus

Type-2 diabetes mellitus (T2DM) remains a leading contributor to cardiovascular mortality worldwide. This study was conducted to investigate the pattern of circulating endothelial progenitor cells (EPCs) in T2DM patients in comparison with MetS subjects in relation to inflammatory changes. Methods: The study retrospectively evolved 101 patients (54 subjects with T2DM and 47 patients with MetS) and 35 healthy volunteers. The flow cytometry was used for predictably distinguishing cell subsets, which depend on expression of CD45, CD34, CD14, Tie-2, and VEGFR2. Biomarkers were measured at baseline of the study. Results: Patients with MetS have demonstrated lower incidence of dyslipidemia, lower concentrations of HbA1c, fasting blood glucose, insulin, and LDL-C when compared with T2DM subjects. Higher HDL-C and HOMA-IR were found in T2DM patients than in MetS subjects. There is a significant difference between the medians of absolute numbers and frequencies of CD14+CD309+ and CD14+CD309+Tie2+ in healthy volunteers and patients with dysmetabolic disorders respectively. CD14+CD309+ and CD14+CD309+Tie2+ subsets of circulating EPCs were determined in higher concentration among MetS subjects in comparison with T2DM patients. Osteoprotegerin (OPG) and hs-C-reactive protein (CRP), improve significantly predictive model based on T2DM + number of multiple cardiovascular risk factors (MCRFs) >3 for decreased both angiopoetic phenotypes of circulating EPCs. In conclusion, we suggest that inflammatory biomarkers (hs-CRP, OPG) may consider statistically significant predictors for decreased EPCs labeled CD14+CD309+ and CD14+CD309+Tie2+ among dysmetabolic patients without preexisting atherosclerotic lesions of coronary arteries.
DEVELOPMENT AND VALIDATION OF MELOXICAM IN HUMAN PLASMA AND APPLICA

Objective: To develop and validate a modified isocratic reversed method for determination of Meloxicam in human plasma Methods: The drug was extracted from plasma samples by direct protein precipitation technique using was used as internal standard (IS). Samples were analyzed on (0.17M): acetonitrile, at a ratio of 62:38 v/v in isocratic mode as a mobile phase at a flow rate of spectra autosampler, separations were performed at room temperature and monitored at a wavelength of into the HPLC system. The analytical method was validated according to F pharmacokinetic study of Meloxicam tablets (Mobic 12 healthy male adult volunteers under fasting condition. Twenty blood samples were withdrawn from each volunteer over 72 the plasma concentration-time data of each individual, the calculated. Results: A peak area was obtained for piroxicam and concentration range of 50– 1500ng/ml with R reproducible at 50ng/ml with a precision of 1.012%. The coefficients of variation(% CV) of the intra 1200ng /ml levels were found to be 2.906%, 1.139% criteria limits (15-20 %). The relative recovery (%) of respectively. Stability at different conditions and in AUC0-∞, Cmax/AUC0-∞, β and t0.5 were; 1262.2 ng/ml, 4.8 hr, Conclusion: The present analytical method was found to be specific, sensitive, accurate and precise for quantification of plasma. It can be successively applied for pharmacokinetics
International Journal of Innovative Technology and Exploring Engineering (IJITEE)

The authors believe that the strategy of modern education should be aimed at updating the content of education and developing mechanisms for its mastering in accordance with the realities of the modern world and the psychology of present-day childhood. The article reveals the ways of finding answers to the issues, which are topical for modern education, namely, how to convey to pupils the necessary amount of fundamental and most modern knowledge, how to ensure knowledge acquisition, how to spark children's interest in learning the world, and teach them to apply acquired knowledge in practice. Based on the research in the field of cognitive psychology and pedagogy of art, the authors distinguish the factors of creative cognition, describing the "ART+" cross-cultural pedagogical technology and its principles, as well as provide guidelines on the application of technology in the educational process of secondary school to make the learning process fun and creative.
Azurin: A Powerful Anticancer from "A" Local Pseudomonas aeruginosa Isolate

Microbial anticancer compounds such as azurin, constitute promising therapeutic agents against different types of human cancers. They have higher affinity and penetrate cell membranes of the target cancer cells, reaching the target sites, than other peptides used to treat cancers. Classical microbiological techniques were used to isolate 95 Pseudomonas aeruginosa from inpatients and outpatients attended the clinics at Mansoura University Hospitals from January 2010 to July 2012. All isolates were identified using manual biochemical tests and confirmed by the Microscan Walk away 90 systems. The gene encodes for azurin in the local P. aeruginosa isolates was detected using specific oligonucleotide primers in a PCR, amplifying a single 545bp DNA fragment characteristic of azurin gene. Column chromatography (superdex 75) followed by dialysis was used to purify the ammonium sulphateprecipitated azurin to near homogeneity. The crude and partially purified azurins killed the breast cancer cell line, MCF-7 cells, with an estimated IC50= 37.6 μg/ml (pure) for the ATCC 15442 strain and IC50= 3 μg/ml for purified azurin from local isolate II. [Yehia A. Osman, Douaa R. El-Deep and Sadia A. Younis. Azurin: A Powerful Anticancer from A Local Pseudomonas aeruginosa Isolate. J Am Sci 2013;9(12):755-764]. (ISSN: 1545-1003). http://www.jofamericanscience. org. 96
IMMUNOBLOT ASSAY FOR TOXOPLASMOSIS IN SCHIZOPHRENIC PATIENTS

Background: Toxoplasma gondii, is a common intracellular protozoan parasite, it can infect most nucleated cells, including astrocytes and neurons. According to many studies, Toxoplasmosis is one of the infectious causes of schizophrenia which is a severe mental illness. Patients and Methods: The study included hundred patients with symptoms and signs of schizophrenia and hundred normal persons as a control group. Detection of Toxoplasma IgG by ELISA and immunoblotting was done for all groups. Results: Out of one hundred schizophrenic patients Toxoplama gondii IgG was positive in 47 (47 %), negative in 51 (51%) of cases and equivocal in 2 (2 %) cases by ELISA. Toxoplasma IgG assay by immunoblotting for these cases were (52.0 %) in which seroconversion of five cases were detected (2 cases from equivocal plus 3 new cases who were negative by ELISA). Conclusion: There is association between toxoplasmosis and schizophrenia. Immunoblot assay is a sensitive method for detecting toxoplasma gondii IgG seroconversion and confirming the equivocal results.
Bi-Orthogonal Wavelet Transform Based 3-D Image Watermarking on Colour Image

— Watermarking technology is an effective approach to image content authentication and copyright protection, which has got notable achievements in recent years. Watermarking has been utilized by researchers for the security of digital documents. Due to the problems of data amount and color shifted, watermarking techniques on color image was not so widespread studied, although the color image is the principal part for multi-medium usages. In this paper we have proposed a method for watermarking color image on color image using Bi-Orthogonal Wavelet Transform. It consists of both a watermark stamping process which embeds a watermark in a source image, and a watermark extraction process which extracts a Watermark from a stamped image. As to the watermark image, pre-processing is applied first, in which the watermark image is decomposed by one level wavelet transformations. The experiment shows that the algorithm can guarantee the unperceivability and transparency of the digital image.
INFLUENCES OF ACCESS TO GOVERNMENT PROCUREMENT OPPORTUNITIES ON TENDERING PARTICIPATION BY WOMEN IN NAKURU COUNTY, KENYA

Tendering participation determines the success of disadvantaged groups particularly women. This study assessed the influence of Access to Government Procurement Opportunities on tendering participation by women in Nakuru County. Procurement procedures, sensitization and financing were considered. Agency, transaction cost and institutional theories were utilized. Descriptive survey design was adopted with a target population of 297 women. 75 participants were randomly sampled and administered with semi-structured questionnaires. Data was analyzed using descriptive and inferential statistics. Consequently, procurement procedures were responsive to women needs (mean=3.750), there were inadequate controls on tendering processes (mean=3.111), there were capacity building programs on tendering (mean=4.222), women entrepreneurs have limited access to tendering information (mean=3.561), access to financing determines women participation in tendering (mean=4.472), funding from Women enterprise fund enhances tendering participation by women (mean=3.556). There were significant relationships between procurement procedures (r=0.726), government sensitization (r=0.695), financing (r=0.713) and tendering participation by women. In conclusion, tendering processes for women were accountable, there was inadequate access to tendering information, International Journal of Economics, Commerce and Management, United Kingdom Licensed under Creative Common Page 807 financial incapacity and gender imbalance limits women participation in tenders, women needs should be prioritized in procurement; more controls should be incorporated into tendering processes to foster efficiency, women should be regularly trained on procurement procedures, terms and conditions.
Determinants Of Audit Quality: An Empirical Insight From Indonesia

This study aims to analyze the determinants of audit quality and to examine the moderating effect of professional ethics in the relationship between competence, independence, audit tenure, and professional skepticism on audit quality. The population of this study is auditors of the public accounting firm (KAP) in Central Java and DIY. By using purposive sampling, the total sample of this study is 105 respondents. Data are analyzed using multiple linear regression. The results indicate that competence, independence, professional skepticism, and professional ethics have a significant positive effect on audit quality. Furthermore, professional ethics strengthens the relationship between competence and independence on audit quality. The results of this study are expected to contribute to the development of science related to auditing and provide enlightening input for KAP auditors in order to improve audit quality.
Microarray analysis of long non-coding RNA expression in Ankylosing Spondylitis

Ankylosing spondylitis (AS) is a common inflammatory rheumatic disease that affects the axial skeleton, causing characteristic inflammatory back pain, which can lead to structural and functional impairments and a decrease in quality of life. The cause of ankylosing spondylitis is unclear. There is increasing evidence that long (>200nt) non-coding RNAs (ncRNAs) have important regulatory functions in epigenetic regulation and involve in various kinds of disease. This study was to analysis the relationship between long ncRNAs and AS, further understand the basic biology of AS and identify new targets for therapeutics. We used microarray and realtime PCR to analysis the long ncRNAS in AS. In this study, we found differential expression hundreds of long ncRNAs in AS between patients and the controls through microarray analysis and quantitative real-time RT PCR confirmation, many ncRNAs surround or overlap protein-coding genes and can be predicted to function via a range of regulatory mechanisms. These ncRNAs may be new biomarkers, at the same time, let us understand the basic biology of AS and identify new targets for therapeutics.
Evaluation of Adherence to Guidelines for Treatment of Acute Pharyngitis and Sinusitis in US Outpatient Settings

The aim of this study was to look at the appropriateness of prescribing patterns for acute sinusitis and acute pharyngitis and compare with treatment guidelines issued by the Center for Disease Control and Prevention (CDC). 2015 National Ambulatory Medical Care Survey (NAMCS) data were used to determine antibiotic prescribing practices of providers treating the two conditions. Inclusion criteria were primary diagnosis of acute sinusitis and acute pharyngitis. Amoxicillin or penicillin, as recommended first-line treatment, were considered appropriate agents for the purposes of this study. Demographic variables, such as gender, age and race were examined along withprescribing variables, including insurance type, geographic area and physician type. In 46 (23.8%) cases,inappropriate agent was chosen. General doctors (14), pediatricians (12) and otolaryngologists (10) were prescribed most of inappropriate prescriptions. Inappropriate antibiotics were often prescribed for patients under 15 (11) and 45 to 64 (11) years of age (X2=0.318), white patients (27) (X2=0.411), those with private insurance (30), (X2=0.726) and from South (13) and West (16) regions (X2 =0.410). Chi-square test found no correlation amongst gender, age, race, insurance type, geographic area or physician type being predictors of appropriate or inappropriate prescribing patterns. Binary logistic regression did not show strong interactions amongst the variables in terms of prescribing pattern, and R2 was found to be significant. Adherence to CDC guidelines to treat acute pharyngitis and sinusitis can decrease the risk of bacteria developing resistance and translate into better clinical outcomes. Future research should continue identifying antibiotic prescribing trends for subsequent years.