Miracle-dz/UniFAR-FTUs huggingface dataset:
Analysis of Lacrimal Duct Morphology from Cone-Beam Computed Tomography Dacryocystography in a Japanese Population

Purpose The dacryoendoscope is a practical instrument for the examination and the treatment of lacrimal duct obstruction. Nevertheless, as it is a rigid fiberscope, manipulation of the endoscope is somewhat affected by the patient’s lacrimal duct alignment and the skeletal structure of the face. The morphology and inclination of the lacrimal duct vary among individuals and ethnic groups. We aimed to evaluate the alignment of the lacrimal duct from the perspective of endoscopic maneuverability in a Japanese population. Methods This retrospective study analyzed the cone-beam computed tomography dacryocystography (CBCT-DCG) images of 102 patients diagnosed with unilateral primary acquired nasolacrimal duct obstruction (PANDO) at Ehime University Hospital from December 2015 to May 2021. The following parameters of the lacrimal duct on the contralateral side of unilateral PANDO were investigated: (1) angle formed by the superior orbital rim–internal common punctum–nasolacrimal duct opening, (2) angle formed by the lacrimal sac and the nasolacrimal duct, (3) length of the lacrimal sac, and (4) length of the nasolacrimal duct. Results Measurements of the above parameters were (1) 10.2° ± 7.8° (range, −11° to +27°), (2) −6.3° ± 14.1° (range, −43° to +40°), (3) 8.9 ± 2.3 mm (range, 4.3–17.1), and (4) 13.2 ± 2.7 mm (range, 5.7–20.7), respectively. The Shapiro–Wilk test demonstrated that the values of all parameters, except (3), followed a normal distribution (p = 0.55, 0.30, 0.0002, and 0.39, respectively). No significant difference was found between the female and male groups (p > 0.05). Conclusion This study reported anthropometric analysis data of the morphology of the lacrimal ducts using CBCT-DCG in a Japanese population. In our cohort, the line from the superior orbital rim through the internal common punctum to the nasolacrimal duct opening inclined anteriorly in 92% of the patients.
Pandemic crisis and employee skills: how emotion regulation and improvisation limit the damaging effects of perceived pandemic threats on job performance

This study details the possible escalation of employees' perceptions of pandemic threats into diminished job performance, while considering a mediating role of their sense of job insecurity and a moderating role of their emotion regulation and improvisation skills. Results based on multisource, three-wave data show that employees' perceived pandemic threats compromise their work-related performance, because they believe that their job is at risk. This mediating role of perceived job insecurity is mitigated by employees' greater ability to control their emotions and come up with novel ideas on the spot. This study accordingly pinpoints employees' conviction that they may not be able to keep their jobs as a crucial mechanism by which the hardships of a global pandemic generate negative performance consequences, as well as how organizations can contain this risk by helping employees hone their pertinent personal skills.
Captioning Transformer with Stacked Attention Modules

Image captioning is a challenging task. Meanwhile, it is important for the machine to understand the meaning of an image better. In recent years, the image captioning usually use the long-short-term-memory (LSTM) as the decoder to generate the sentence, and these models show excellent performance. Although the LSTM can memorize dependencies, the LSTM structure has complicated and inherently sequential across time problems. To address these issues, recent works have shown benefits of the Transformer for machine translation. Inspired by their success, we develop a Captioning Transformer (CT) model with stacked attention modules. We attempt to introduce the Transformer to the image captioning task. The CT model contains only attention modules without the dependencies of the time. It not only can memorize dependencies between the sequence but also can be trained in parallel. Moreover, we propose the multi-level supervision to make the Transformer achieve better performance. Extensive experiments are carried out on the challenging MSCOCO dataset and the proposed Captioning Transformer achieves competitive performance compared with some state-of-the-art methods.
Association between Hematology Indices as Early Markers and Urinary Tract Infection, Septicemia, Pneumonia, and Diabetic Foot Infection

they were hospitalized in Rasoul Akram hospital in Iran from August 2017 to February 2018. Patients’ demographic and laboratory data, such as RDW (red cell distribution width), PDW (platelet distribution width), RBC (red blood cell), CRP (C-reactive protein), ESR (erythrocyte sedimentation rate), and, WBC (white blood cells), were evaluated. Findings: This study results showed that mortality rate in sepsis cases was higher than in other cases (42.1%). Changes in blood parameters such as RDW, PDW, and EDR levels as well as monocyte, basophil, and eosinophil counts were significant among patients with different infectious diseases, while there was no significant difference in terms of changes in some blood parameters, such as WBC, neutrophil, and lymphocyte counts and CRP level between patients with different infectious diseases. For statistical analysis, one-way ANOVA and LSD post hoc tests were used. Conclusion: According to this study results, it was found that the range of blood parameters varies in different types of infectious diseases. Therefore, the could employ routine blood parameters along with other diagnostic factors to more accurately diagnose the type of infection prescribe appropriate
Pyrimethamine Significantly Lowers CSF/SOD1 in ALS Patients With SOD1 Mutations

Background: Cu/Zn superoxide dismutase (SOD1) reduction prolongs survival in SOD1-transgenic animal models. Pyrimethamine produces dose dependent SOD1 reduction in cell culture systems. A previous phase-1 trial showed pyrimethamine lowers SOD1 levels in leucocytes in patients with SOD1 mutations. This study investigated whether pyrimethamine lowered SOD1 levels in the cerebrospinal fluid (CSF) in patients carrying SOD1 mutations linked to ALS (fALS/SOD1). Methods and Study Design: Multicenter (5 sites), open-label, 9-month duration, doseranging, to determine safety and efficacy of pyrimethamine to lower SOD1 levels in the CSF of FALS/SOD1. All participants underwent 3 lumbar punctures, blood draw, clinical assessment of strength, motor function, quality of life, and adverse effects assessments. SOD1 levels were measured in erythrocytes and CSF. Pyrimethamine was measured in plasma and CSF. Appel ALS, ALSFRS-R and single item McGill Quality of Life (SISMQoL) were measured at screening, visit 6 and 9. Results: We enrolled 32 patients; 24 completed 6 visits (18 weeks) and 21 completed all study visits. A linear mixed effects model showed a significant reduction in CSF SOD1 at visit 6 (p<0.001) with a mean reduction of 13.5% (95% CI: 8.4, 18.5) and at visit 9 (p<0.001) with a mean reduction of 10.5% (95% CI: 5.2, 15.8). Interpretation: Pyrimethamine is safe and well tolerated in ALS. Pyrimethamine is capable of producing a significant reduction in total CSF SOD1 protein content in patients with ALS caused by different SOD1 mutations. Further long-term studies are warranted to assess clinical efficacy. Page 2 of 23 John Wiley & Sons Annals of Neurology This article is protected by copyright. All rights reserved.
Structure-Functional Characteristics of the Svx Protein—The Virulence Factor of the Phytopathogenic Bacterium Pectobacterium atrosepticum

The Svx proteins are virulence factors of phytopathogenic bacteria of the Pectobacterium genus. The specific functions of these proteins are unknown. Here we show that most of the phytopathogenic species of Pectobacterium, Dickeya, and Xanthomonas genera have genes encoding Svx proteins, as well as some plant-non-associated species of different bacterial genera. As such, the Svx-like proteins of phytopathogenic species form a distinct clade, pointing to the directed evolution of these proteins to provide effective interactions with plants. To get a better insight into the structure and functions of the Svx proteins, we analyzed the Svx of Pectobacterium atrosepticum (Pba)—an extracellular virulence factor secreted into the host plant cell wall (PCW). Using in silico analyses and by obtaining and analyzing the recombinant Pba Svx and its mutant forms, we showed that this protein was a gluzincin metallopeptidase. The 3D structure model of the Pba Svx was built and benchmarked against the experimental overall secondary structure content. Structure-based substrate specificity analysis using molecular docking revealed that the Pba Svx substrate-binding pocket might accept α-glycosylated proteins represented in the PCW by extensins—proteins that strengthen the PCW. Thus, these results elucidate the way in which the Pba Svx may contribute to the Pba virulence.
Live tweeting the planning reform workshop

ABSTRACT Planning conferences and workshops create opportunities for distributing ideas and learning for planning practitioners, stakeholders and the community. Social media can contribute to communications at these events. This article employs content analysis to examine how Twitter can be used by planners and other stakeholders at workshops as a digital backchannel that runs parallel to the proceedings being conducted in the shared physical space. Our Analysis reveals Twitter can provide alternative questions and answers and raise topics or issues not discussed in the formal consultation space. Additionally, Twitter users also switch between roles of commenting directly on workshop proceedings to describing or commenting on other aspects the workshop such as presenters and audience behaviour to provide an extended commentary of proceedings. Accordingly, Twitter extends participation and information distribution beyond the physical space by allowing those unable to attend, or who may not be invited, to potentially contribute to the discussion.
The Outcome of Neurorehabilitation Efficacy and Management of Traumatic Brain Injury

For public health professionals, traumatic brain injury (TBI) and its possible protracted repercussions are a significant source of worry. In opposed to patient neurorehabilitation with developed brain abnormalities of different etiologies, neurorehabilitation of affected persons has several distinct features. The clinical repercussions of the various types of TBI injuries will be discussed in detail in this paper. During severe TBI, the medical course frequently follows a familiar first sequence of coma, accompanied by disordered awareness, followed by agitation and forgetfulness, followed by return of function. Clinicians must be aware of common medical issues that might occur throughout the various stages of neurorehabilitation, for example, posttraumatic hydrocephalus, paroxysmal sympathetic hyperactivity and posttraumatic neuroendocrine disorders, at each step of the process. Furthermore, we address problems about the scheduling of various rehabilitation programs as well as the availability of current data for comprehensive rehabilitative neuropsychology techniques.
Alcohol Use and Misuse Among Chinese Psychiatrists During the Early COVID-19 Pandemic

Aim Survey alcohol use and misuse among Chinese psychiatrists during the Coronavirus diseases 2019 (COVID-19) pandemic. Methods We conducted a large-scale, nationwide online survey of psychiatrists regarding their alcohol use during the pandemic. The Alcohol Use Disorder Identification Test-Concise (AUDIT-C) was used to assess alcohol use and misuse. Results Of 3,815 psychiatrists who completed the survey, alcohol use and misus were 47.5% and 8.2%, respectively, and both were significantly higher in males. The majority (59%) reported no change in alcohol use during the pandemic, one-third (34.5%) reported a decrease, and 6.5% reported an increase. Alcohol misuse was associated with middle-age (OR = 1.418), male sex (OR = 5.089), Northeast China (OR = 1.507), cigarette-smoking (OR = 2.335), insomnia (OR = 1.660), and regular exercise (OR = 1.488). A master's degree (OR = 0.714) and confidence in clinical work (OR = 0.610) were associated with less alcohol misuse. Those who reported a decrease in alcohol use during the pandemic were more likely to be male (OR = 2.011), located in Northeast China (OR = 1.994), and feel confident in their clinical work (OR = 1.624). Increased alcohol use was significantly associated with insomnia (OR = 3.139). Conclusions During the COVID-19 pandemic, alcohol use and misuse among Chinese psychiatrists declined. While males were more likely to misuse alcohol, they were also more likely to have reduced their intake. Age, location, and lifestyle factors also predicted alcohol use and misuse. Further examination of specific factors that reduced alcohol use and misuse may help guide public health efforts to sustain the lower rates beyond the pandemic.
Generalized and Specific Problematic Internet Use in Central Siberia Adolescents: A School-Based Study of Prevalence, Age–Sex Depending Content Structure, and Comorbidity with Psychosocial Problems

We aimed to assess the prevalence, content structure and, psychological comorbidity of PIU in Russian adolescents. In addition, the design of our research provided an opportunity to compare demographic and psychological patterns of different forms of PIU: generalized (PIUgen) and specific problematic video game use (PUgame), as well as problematic social media use (PUsocial). Methods: This is a one-stage cross-sectional observational study of school sampling in three major Siberian cities. A total of 4514 schoolchildren aged 12–18 (mean age 14.52 ± 1.52 years) were surveyed. The Chen Internet Addiction Scale, the Game Addiction Scale for Adolescents, and the Social Media Disorder Scale were used to identify PIU and its types. Results: The prevalence of PIUgen among adolescents in Central Siberia was 7.2%; the prevalence of PUgame was 10.4%; the prevalence of PUsocial was 8.0%. The results of structural equation modelling, as well as the correlation analysis data, suggest two possible patterns of psychosocial problems with PIU—the first one is characteristic of both PIUgen and PUsocial. The second one—which is significantly different—is characteristic of PUgame. Conclusions: Urban adolescents in Central Siberia do not differ significantly from their Asian and European peers. Our findings support the concept of rejecting the term “generalized PIU” as a single psychological construct.
Three W’s of in-depth journalism portraying socio-environmental conflicts in Chilean television: What (the agenda), who (the sources), and where (the locations)

This article offers a case study of the Chilean investigative broadcasting journalism uncovering disasters and socio-environmental conflicts. Drawn from an analysis of 17 long-form stories aired by the two main television shows on current affairs in the country, we show that in-depth reporting on Chilean television was chronicling some of the most acute environmental issues since 1990s. Indeed, almost 13 hours of footage assembly a visual memory of conflicts in a society fueled by an extractivist based economy. It is noticeable a geographic diversity when covering the environment, as well as when covering waste production and pollution. Despite a relative diversity in sources, there is a sharp unbalance on gender representation. This article addresses the much-needed research on environment and communication while most of these studies pay attention to industrialized nations. It also contributes to building a situated knowledge considering the specificities of in-depth journalism in South America.
Reconceptualizing Women's Wellbeing During the Pandemic: Sport, Fitness and More-Than-Human Connection

This paper explores the gendered, disruptive effects and affective intensities of COVID-19 and the ways that women working in the sport and fitness sector were prompted to establish more-than-human connection through technologies, the environment, and objects. Bringing together theoretical and embodied insights from object interviews with 17 women sport and fitness professionals (i.e., athletes, coaches, instructors) in Aotearoa New Zealand, this paper advances a relational understanding of the multiple human and nonhuman forces that shape and transform women's wellbeing during pandemic. Drawing upon particular feminist materialisms (i.e., Barad, Braidotti, Bennett), we reconceptualize wellbeing to move beyond biomedical formulations of health or illness. Through our analysis and discussion, we trace embodied ways of knowing that produce wellbeing as a more-than-human entanglement, a gendered phenomenon that can be understood as an ongoing negotiation of affective, material, cultural, technological and environmental forces during a period of disruption and uncertainty.
Three new Achnanthidium (Bacillariophyceae) species from Lake Salda (Anatolia, Turkey), a deep soda lake

Background and aims – Kützing separated the genus Achnanthidium from the genus Achnanthes based on two species: Achnanthes minutissima and Achnanthidium microcephalum. These two genera were distinguished by the presence of stalks in the Achnanthes genus and their absence in Achnanthidium. Before electron microscopy, the difference between Achnanthes and Achnanthidium was not clear, especially in Achnanthidium minustissimum sensu lato. The aim of the study is to describe three new species of Achnanthidium from Lake Salda. Material and methods – Lake Salda is located in southwestern Anatolia, in Turkey. The diatoms were collected seasonally from four stations in the lake between 2016 and 2020, from different substrata (epipelic, epiphytic, and epilithic). Key results – Three new species belonging to the genus Achnanthidium have been found in Lake Salda, Turkey. Based on the morphological observations, all new taxa are part of the Achnanthidium minutissimum complex. Achnanthidium barlasii sp. nov. and A. dumlupinarii sp. nov. show a high degree of similarity to each other, but can be separated based on valve outline and a denser areolation, especially in striae close to the apices of the raphe valve. Both species can be distinguished from A. minutissimum based on more separate apices and less elliptic valves. In the case of A. dumlupinarii sp. nov., large specimens show slight undulations of the valve, which is a unique feature. Achnanthidium anatolicum sp. nov. is the most characteristic based on its valve width, broadly rounded valve apices, and almost straight valves in girdle view. All newly described Achnanthidium species can be found in lentic environments, with alkaline water and high calcium ion content. Conclusion – The newly described taxa occurred in the unique habitat of a soda lake. The environment of the lake is highly alkaline, rich in magnesium and calcium, and derived from limestone and dolomitic limestone rocks.
The Consequences of not Being Me: Longitudinal Examination of the Relations Among Anticipated Discrimination, Authenticity, and Counterproductive Work Behaviors

The current study examines the relations among anticipated discrimination, authenticity, and counterproductive work behaviors (CWBs) in an employee population that is vulnerable to mistreatment—namely, employees with depression and bipolar disorder. Using a longitudinal research design, we collected data at 3 points in time from 279 individuals diagnosed with depression and/or bipolar disorder. We tested the extent to which authenticity mediated the relationship between anticipated discrimination and counterproductive work behaviors. Our results provided support for our research model. Thus, when individuals perceived that they were likely to be targets of discrimination due to their mental illness, it resulted in increased counterproductive work behaviors, and this effect was transmitted through decreased perceptions of authenticity. In addition, we tested stigma centrality and symptom severity moderators of the mediated relationships. We found support for symptom severity (but not stigma centrality) as a moderator in which the mediated relationship between anticipated discrimination and CWBs through authenticity was stronger for those with more severe symptoms.
Application of Convolutional Neural Networks With Object-Based Image Analysis for Land Cover and Land Use Mapping in Coastal Areas: A Case Study in Ain Témouchent, Algeria

Land use and land cover (LULC) information is a fundamental component of environmental research relating to urban planning, agricultural sustainability, and natural hazards assessment. In particular, remote sensing technology has demonstrated a powerful capacity for LULC modeling with a corresponding increase in sensor number and type. Here, an advanced convolutional neural network (CNN) deep learning model was developed in combination with object-based image analysis (OBIA) to map LULC in Ain Témouchent coastal area, western Algeria, using sentinel-2 and Pléiades imagery data. First, the CNN model was constructed based on convolution, hidden, and max pooling layers. The parameters of CNN architecture were optimized to improve the model for further processing. Then, based on high levels of CNN feature extraction, the OBIA was applied to classify the segmented objects, and detect the LULC features. Furthermore, machine learning methods, including random forest and support vector machines were tested for comparison. The proposed method achieved a high overall accuracy (93.5%) using Pléiades imagery, revealing significant improvements compared to other machine learning techniques. Accordingly, it was concluded that the method proposed here is useful for LULC detection, and can be applied at larger scales in coastal areas. The derived maps can also inform regional and national-level decision making.
Using Flipgrid as an Interactive Application to Improve Filipino Students’ Engagement in Language Flexi-Learning

The pandemic's massive impact on schools has pushed teachers and students to migrate online and affected students' class engagement. With this, the action research aimed to 1) analyze the previous experiences of the students with other interactive applications, 2) determine if Flipgrid interactive options are an intervention for improving students' engagement, and 3) evaluate the experiences of the students in using Flipgrid interactive options in asynchronous learning. The research used a practical action research design that utilizes mixed methods to address the study's problem and was conducted at Xavier University – Junior High School in the Philippines. To achieve the desired results, the researchers first gave the interactive questionnaire, followed by a survey questionnaire before and after the implementation of the proposed intervention, and conducted a focus group discussion to gather more in-depth information. Twenty respondents took the pre-test, and 17 took the post-test. The results of the data from the statistics and information gathered during the focus group discussion show that students are favorable of the features of Flipgrid. There is also a highly significant difference between the pre-test and post-test results, which means that the proposed intervention, comment section, and view counts effectively alleviate the challenge of students' engagement in asynchronous learning. Based on the perceived response from the participants, Flipgrid, in general, is a great tool to boost students' engagement. Thus, the researchers recommend that teachers maximize the use of Flipgrid for asynchronous sessions.