Miracle-dz/UniFAR-FTUs huggingface dataset:
Contemporary Fixed Prosthodontics

The student will gain knowledge in the principles of fixed prosthodontics for the . *REFERENCES: *CFP Contemporary Fixed Prosthodontics, 4th Edition . Rosenstiel, Land, Fujimoto. Contemporary Fixed Prosthodontics 4th ed. Implant-supported Fixed Prosthodontics. Implant length o Longer = greater surface area Fundamentals of. Fixed Prosthodontics 4th Edition. Hanover: Quintessence, 2012. Rosenstiel, Stephen F. , et al. Contemporary Fixed. Prosthodontics 4th Edition. Jan 13, 2007 Handbook of Local Anesthesia Fifth Edition p. 242. will always be increased. Source: Rosenstiel et al, Contemporary Fixed Prosthodontics; 4th edition . Shillingburg, H. Fundamentals of Fixed Prosthodontics, 3rd Edition.
Lung function in relation to six-minute walk test in pulmonary hypertension

ABSTRACT Background: Pulmonary hypertension (PH) is a progressive disorder of the pulmonary circulation, associated with diverse medical conditions. Exercise limitation is the most prominent symptom in PH. Exercise capacity, commonly assessed through a six-minute walk test (6MWT), correlates with both functional status and survival in PH. Few studies have analysed the relation between respiratory function and exercise limitation. Therefore, we investigated the relationship between resting pulmonary function, exercise capacity, and exertional desaturation, assessed through the 6MWT, in unselected PH patients. Methods: Fifty consecutive patients with PH diagnosis, referred for pulmonary function testing (lung volume, spirometry, and diffusing capacity for carbon monoxide (DLCO)) and 6MWT, were recruited at Molinette University Hospital, Turin. Results: The majority of the patients (54%) had PH due to left heart disease. Airway obstruction (FEV1/VC-ratio < 0.7) was found in 46% of the patients and they performed significantly worse in the 6MWT than unobstructed patients (307 m vs. 377 m). Patients with PH due to left heart disease also performed significantly poorer 6MWT when airway obstruction was present (305 m vs. 389 m). Twenty-two patients (44%) presented exertional desaturation upon 6MWT. Lower DLCO divided by the alveolar volume (DLCO/VA), FEV1/VC-ratios and resting PaO2-values were significantly correlated with exertional desaturation after adjustments for age, sex, BMI, and smoking habits. DLCO/VA was the main determinant of exertional desaturation in a stepwise regression model. Conclusions: Spirometric parameters of airway obstruction were related to walk distance and exercise-induced desaturation in PH patients. This suggests a place for spirometry in clinical monitoring of PH patients.
High-Sensitivity Cardiac Troponin in the Distinction of Acute Myocardial Infarction From Acute Cardiac Noncoronary Artery Disease

Background— We hypothesized that high-sensitivity cardiac troponin (hs-cTn) and its early change are useful in distinguishing acute myocardial infarction (AMI) from acute cardiac noncoronary artery disease. Methods and Results— In a prospective, international multicenter study, hs-cTn was measured with 3 assays (hs-cTnT, Roche Diagnostics; hs-cTnI, Beckman-Coulter; hs-cTnI Siemens) in a blinded fashion at presentation and serially thereafter in 887 unselected patients with acute chest pain. Accuracy of the combination of presentation values with serial changes was compared against a final diagnosis adjudicated by 2 independent cardiologists. AMI was the adjudicated final diagnosis in 127 patients (15%); cardiac noncoronary artery disease, in 124 (14%). Patients with AMI had higher median presentation values of hs-cTnT (0.113 &mgr;g/L [interquartile range, 0.049–0.246 &mgr;g/L] versus 0.012 &mgr;g/L [interquartile range, 0.006–0.034 &mgr;g/L]; P<0.001) and higher absolute changes in hs-cTnT in the first hour (0.019 &mgr;g/L [interquartile range, 0.007–0.067 &mgr;g/L] versus 0.001 &mgr;g/L [interquartile range, 0–0.003 &mgr;g/L]; P<0.001) than patients with cardiac noncoronary artery disease. Similar findings were obtained with the hs-cTnI assays. Adding changes of hs-cTn in the first hour to its presentation value yielded a diagnostic accuracy for AMI as quantified by the area under the receiver-operating characteristics curve of 0.94 for hs-cTnT (0.92 for both hs-cTnI assays). Algorithms using ST-elevation, presentation values, and changes in hs-cTn in the first hour accurately separated patients with AMI and those with cardiac noncoronary artery disease. These findings were confirmed when the final diagnosis was readjudicated with the use of hs-cTnT values and validated in an independent validation cohort. Conclusion— The combined use of hs-cTn at presentation and its early absolute change excellently discriminates between patients with AMI and those with cardiac noncoronary artery disease. Clinical Trial Registration— URL: http://www.clinicaltrials. gov. Unique identifier: NCT00470587.
Abnormal Eye and Cranial Movements Triggered by Examination in People with Functional Neurological Disorder

ABSTRACT The diagnosis of functional neurological disorder (FND) relies on the demonstration of positive symptoms and signs, as supported by recent changes in DSM5. We recorded the findings of routine clinical eye movement assessment in 101 consecutive new patients with FND. Clinical examination triggered facial and eye movement disorders in 46% of patients, all with positive characteristics of functional movement disorder. These are useful as supporting features in making a positive diagnosis of FND.
Examining the Link Between Social Anxiety and Alcohol Use: The Role of Post-Event Processing

Post-event processing (PEP) involves a negative, self-focused review of one’s performance in past social events. PEP is common in social anxiety (SA); by increasing anticipation of failure for future social events, PEP serves to maintain anxiety. Research is needed to clarify the association between SA and PEP in the context of alcohol use, given that although socially anxious individuals are at increased risk of drinking problems, this risk pathway is poorly understood. To help resolve this, the present two studies aimed to assess the role of PEP in the link between SA and alcohol use among two samples of young adults who ranged in SA severity. Study 1 used a 3-week diary (via smartphone) to assess alcohol intoxication during, and PEP after, social events in a sample of individuals (N=92) high (n=40) and low (n=52) in SA. Of interest was the association between PEP and next-event intoxication, and the moderating effect of SA. Compared to the low SA group, those high in SA reported more PEP, similar intoxication, and a positive correlation between PEP and next-event intoxication. In the low SA group PEP and intoxication were unrelated. Multilevel models supported a SA by PEP interaction in the high SA group only. Specifically, increases in PEP corresponded with increases in intoxication at the next event, but only for those moderately high in SA. Study 2 used a lab-based procedure, and participants (N=103) consumed alcoholic (n=52) or non-alcoholic (n=51) beverages, engaged in an anxiety-provoking interaction, and completed follow-up assessments of PEP about the interaction (sent via email). Regression models supported a SA by drinking status interaction in predicting PEP in the alcohol condition only. Specifically, for those who consumed alcohol before the interaction, elevated (baseline) SA was associated with increased PEP, but only for light drinkers. For heavy drinkers in the alcohol condition, SA was unrelated to PEP. These results underscore the importance of PEP, and variables that influence PEP, in understanding the link between SA and alcohol use. The results are discussed in terms of theoretical and clinical considerations.
A proteomics approach to the study of bleomycin- induced lung fibrosis

Idiopathic pulmonary fibrosis (IPF) is the most severe lung fibrotic form and very few pharmacological therapies are available at present. Key events in the onset of the disease are the activation of fibroblasts to myofibroblasts and the production and release of extracellular matrix (ECM) and molecular factors. Primary murine lung fibroblasts were isolated and their activation induced by Bleomycin (BLM) treatment. Extracellular Vesicles (EV) were isolated and protein extracted. Released soluble proteins (Secretome) and EV-derived proteins were reduced, alkylated and trypsin digested. A nano-LC-MS/MS SWATHTM approach was used for the proteomics analyses. Specific proteins with a putative role in the transition from physiological to fibrotic conditions, such as several matrix metalloproteinases (MMPs), osteopontin (OPN), chitinase-3-like protein1 (CHI3L1) and CD44 resulted differentially released from BLM-treated fibroblasts as compared with untreated lung fibroblasts. Our results provide further understanding of the pathophysiological features of lung fibrosis, and suggest specific target for pharmacological treatments. Abbreviations: BCA: Bicinchoninic Acid; BLM: Bleomycin; CHI3L1: Chitinase-3-Like Protein 1; DAB: Dark Brown Stain; DMEM-HG: Dulbecco’s Modified Eagle Medium High Glucose, 4500 mg/L; ECM: Extracellular Matrix; EMT: Epithelial-Mesenchymal Transformation; FBS: Fetal Bovine Serum; FSP-1: Fibroblast-Specific Protein 1; GSN: Gelsolin; H&E: Haematoxylin and Eosin; H2O2: Hydrogen Peroxide; IIPs: Idiopathic Interstitial Pneumonias; IPF: Idiopathic Pulmonary Fibrosis; MANOVA: Multifactor Analysis Of Variance; MMP-1: Matrix Metalloproteinases-1; MMP-2: Matrix Metalloproteinases-2; MMP-3: Matrix Metalloproteinases-3; MMP-7: Matrix Metalloproteinases-7; MMP-9: Matrix Metalloproteinases-9; MMPs: Matrix Metalloproteinases; OPN: Osteopontin; PBS: PhosphateBuffered Saline; PDGF: Platelet-Derived Growth Factor; PRDX2: Peroxiredoxin 2; PRDX6: Peroxiredoxin 6; RNS: Reactive Nitrogen Species; ROS: Reactive Oxygen Species; S100A4: S100 CalciumBinding Protein A4; Tagln-2: Transgelin-2; TGF-β1: Transforming Growth Factor-β1; TNF-α: Tumor Necrosis Factor-α; Vim: Vimentin; α -sma: α-Smooth Muscle Actin.
Faktor risiko mempengaruhi kejadian Diabetes mellitus tipe dua

Pasien Diabetes Mellitus dapat hidup normal dengan mengendalikan faktor risiko. Tujuan penelitian ini untuk mengetahui faktor risiko Diabetes Mellitus tipe dua. Desain studi non-eksperimental, atau juga bisa disebut dengan observasional, menggunakan desain penelitian cross-sectional. Populasi adalah warga yang berada di wilayah kerja Puskesmas I Wangon. Teknik purposif sampel sebanyak 106 orang dengan pembagian 53 kasus dan 53 kontrol. Analisa data menggunakan uji chi-square. Faktor risiko yang terbukti berpengaruh dengan DM tipe dua di Puskesmas I Wangon adalah faktor genetik dengan keluarga DM (OR=10,938), pola makan tidak sehat, umur ≥45 tahun, IMT obesitas, dan tingkat pendidikan rendah.
Exfoliative cytology for age estimation: A correlative study in different age groups

Background: Oral exfoliative cytology is a simple and relatively pain-free procedure which can be carried out repeatedly with minimum discomfort to the patients. Oral exfoliative cytology has a sensitivity of 89.5%; its accuracy could be enhanced by cytomorphometric analysis of the cells. Aim and Objective: The present study was undertaken to evaluate the cell diameter (CD), nuclear diameter (ND), and nuclear-cytoplasmic ratio (N:C) and their variation with age using buccal smears. Materials and Methods: Buccal smears were collected from 100 apparently normal healthy individuals. The patients were divided into five groups 10–20, 21–30, 31–40, 41–50, and more than 50 years. The smears were fixed and stained. The CD and ND were measured using MS paint tool. The CD, ND, and nuclear-cytoplasmic (N:C) ratio were calculated for each case. Results: The cytomorphometric analysis of the exfoliated normal buccal mucosal cells revealed that there is a decrease in CD and ND with increasing age. No variation is found in N:C ratio. Conclusion: Age-related changes are observed in buccal smears, which could be helpful in age estimation.
Post Discharge Follow-up Telephone Calls for Patients who Received Hospital Based Palliative Care Services to Improve Quality of Care and Outcomes: A Pilot Study

There is a rising number of patients with chronic health conditions concurrent with an increasing number of hospital readmissions within 30 days and emergency department visits. Predominantly based in acute care facilities, palliative care services have been effective in improving the quality of life in patients with chronic health conditions. However, the largest population that could benefit from palliative care services is community based in the home setting. The purpose of this project was the implement and evaluate follow-up telephone calls made in addition to visiting nursing (VNA) services to detect in early decline in patients who have received in-patient palliative care services compared to a 12-month retrospective analysis of a mirror population. Five telephone calls were made over a 30-day time frame using the palliative performance scale as the method of measurement to augment VNA services with an additional layer of monitoring for early detection of decline. A 12-month retrospective analysis of a mirror population was performed for baseline comparison. Emergency department (ED) visits, 30-day hospital readmissions, hospice admissions, and hospice lengths of stay were the methods of outcome. One participant was included in the implement telephone calls for inconclusive results. While, the retrospective data populations of 45 patients accounted for 141 hospitalizations, 71 30-day hospital readmissions, 65 ED visits, 15 hospice admissions, and an average hospice length of stay of 58.3 days. Patients who receive palliative care services in the hospital would benefit from the extension of in-person palliative care into the home setting for better symptom management and advanced care planning to improve quality of care and outcomes.
Contributions to the Mosquito Fauna of Southeast Asia - II. The Genus Culex in Thailand (Diptera: Culicidae)

Abstract : The culicine mosquito fauna of Thailand has received only scant and sporadic interest until recent years. Stanton (1920) recorded species occurring commonly in Bangkok; Edwards (1922) included a few general records from Thailand; Barraud and Christophers (1931) reported on species collected by J. A. Sinton during a 2 week railway tour of the country; Causey (1937) summarized information collected during a 4 year stay in Thailand; and Iyengar (1953) listed 48 species and subspecies from southern areas of Thailand. In this study, 60 species and subspecies belonging to 7 subgenera of the genus Culex are recognized from Thailand. Of these, 5 species are described as new and 19 species are recorded for the first time from Thailand; 7 species previously recorded from Thailand are dismissed as misidentifications and 6 previous records are regarded as doubtful. In addition, 7 names are placed in synonymy and 1 subspecies is elevated to species rank.
Long-Standing Course of Disease in a Patient with Muir-Torre Syndrome

Muir-Torre Syndrome (MTS) is an autosomal dominant disorder characterized by skin neoplasms in association with a visceral malignancy [1]. Visceral malignancies most commonly seen with MTS include colorectal adenocarcinomas and genitourinary malignancies [2], while sebaceous adenomas, epitheliomas and carcinomas constitute the common dermatologic neoplastic conditions usually associated with MTS [2]. Due to its association with germline mutations in the DNA mismatch repair genes MLH1 and MLH2, which occur secondary to DNA microsatellite instability, MTS is considered as a small phenotypic subset of Lynch syndrome [3]. MTS is an exceedingly rare condition, with a high degree of variability in its penetration and expression [4]. Here, we describe a case of a 78-year old man with multiple visceral and dermatologic malignancies who had a prolonged and convoluted course of disease spanning over 40 years.
The evolution of early arthritis and cardiovascular risk

This thesis is devoted to the early phase of rheumatoid arthritis (RA) and focused on three areas: (rheumatoid) arthritis development, cardiovascular comorbidity and remission from the perspective of the patient. From part I we conclude that there are many risk factors of varying strength for the development of RA. Risk factors include genetic factors as well as lifestyle factors also known to increase the risk for other chronic diseases. Part II showed that the body composition of arthritis patients was already unfavorable at the moment of diagnosis in comparison with the general population. Furthermore, the prevalence of cardiac conduction disorders was not increased at diagnosis. As sudden cardiac death is increased in RA patients, conduction disorders might develop after a longer period of inflammation after diagnosis. Our data show that different cardiovascular risk results are obtained, depending on which cardiovascular risk prediction tool is used. The advice for preventive cardiovascular risk medication, according to the Dutch SCORE and risk management guidelines, changed in 13% of the patients after four weeks of anti-rheumatic treatment. Part III demonstrates that after three months of treatment, one-third of the RA patients did not agree with the physician about being in remission. Patients take other domains of disease activity into account (e.g. pain, sleep and emotional wellbeing) than physicians. A possible new definition of remission, with more patient-reported outcomes, could be the normality scale. Patients indicate returning back to normality as important, and the normality scale is able to discriminate between remission and non-remission.
Clinical and Genetic Profiles in Chinese Patients with Huntington’s Disease: A Ten-year Multicenter Study in China

Huntington’s disease (HD) is an autosomal dominant inherited neurodegenerative disorder caused by CAG triplet repeats expansion in exon 1 of the Huntingtin gene (HTT). In China, HD is considered to have a low prevalence. The goal of this study was to describe the clinical characteristic and genetic profiles of HD in a Chinese cohort. A total of 322 individuals with expanded CAG repeats were consecutively recruited from the neurologic clinics of three medical centers in Southeastern China between 2008 and 2018. Among them, 80 were pre-symptomatic mutation carriers and 242 were symptomatic patients. The mean age at onset (AAO), defined here as the age at motor symptom onset, of the 242 manifest HD individuals was 40.3 ± 11.9 years and the mean CAG repeat length was 46.1 ± 7.5 in the group of symptomatic patients. Initial symptoms were abnormal movements in 88.8% of the patients with psychiatric symptoms in 6.2%, cognitive impairment in 3.3% and others in 1.7%. The AAO of motor was negatively correlated with the CAG repeat length in an exponential regression analysis (R 2 = 0.74, P<0.001). Analysis of 46 parent-child pairs showed that the CAG repeat length was longer in the offspring group (45.8 ±7.6) than in the parent group (43.8 ±3.0) (p=0.005). Overall, this study provides clinical and genetic profiles in a cohort of Chinese patients with HD, which should contribute to a better understanding of this disorder.
Cardiac Failure in Transgenic Mice With Myocardial Expression of Tumor Necrosis Factor-α

Background—Tumor necrosis factor-α (TNF-α) is a multifunctional cytokine that has been detected in several human cardiac-related conditions, including congestive heart failure and septic cardiomyopathy. In these conditions, the origin of TNF-α secretion is, at least in part, cardiac myocytes. Methods and Results—To determine the consequences of TNF-α production by cardiac myocytes in vivo, we developed transgenic mice in which expression of a murine TNF-α coding sequence was driven by the murine α-myosin heavy chain promoter. Four transgenic founders developed an identical illness consisting of tachypnea, decreased activity, and hunched posture. In vivo, ECG-gated MRI of symptomatic transgenic mice documented a severe impairment of cardiac function evidenced by biventricular dilatation and depressed ejection fractions. All transgenic mice died prematurely. Pathological examination of affected animals revealed a globular dilated heart, bilateral pleural effusions, myocyte apoptosis, and transmural myocardi.
Familiarisation, reproducibility, sensitivity and joint angle specificity of bilateral isometric force exertions during leg press

BACKGROUND: Strength assessments are used to monitor physical progression and evaluate the impact of training interventions, which is extremely valuable for both athletic performance and clinical populations. For results to be useful, measurements must be relevant, reliable and show sensitivity to change. OBJECTIVES: The aim was to establish the practicality of isometric force assessment at two different knee-joint angles; 90° (ISO90) and 120° (ISO120). More specifically, to address the familiarisation effects, reproducibility and sensitivity of measurements associated with each method of assessment, and the discrepancy in force output when altering the angle at the knee joint. METHODS: Thirty-five strength trained males attended three sessions; familiarisation (T1), test (T2) and retest (T3), separated by 7 days. During each session, ISO90 and ISO120 was assessed using an incline leg press device. RESULTS: Force output was similar during T1, T2 and T3 for ISO90 and ISO120, separately (p > 0.05). Measurements taken from both assessment methods demonstrated good reproducibility (ICC = 0.96, CV < 5%) and showed sufficient sensitivity to detect changes in performance. Force output was greater during ISO120 (5153 ± 1446 N) versus ISO90 (2660 ± 597 N, p < 0.001) but the magnitude of the difference in force output showed great intrasubject variability. CONCLUSION: Isometric assessment performed on a leg press device requires minimal habituation to demonstrate a good degree of reproducibility and sensitivity to detect small changes in performance. It is a simple and practical method to evaluate strength at different joint angles, which may prove useful in strength diagnosis in performance and clinical contexts.
COMPARISON OF DEPRESSION AND DAILY LIVING ACTIVITIES IN GERIATRIC PATIENTS WITH AND WITHOUT NEUROPATHIC PAIN

Girifl: Bu çal›flman›n amac› geriatrik hastalarda nöropatik ve non nöropatik a¤r›n›n, depresyon ve günlük yaflam aktivitelerine etkilerini incelemektir. Gereç ve Yöntem: Çal›flma, yafl ortalamas› 67,2±4,2 olan 234 hasta üzerinde gerçeklefltirilmifltir. Hastalar›n a¤r› süresi, a¤r› fliddeti, a¤r›l› bölge say›s›, kronik hastal›klar›, kulland›klar› ilaçlar, son bir y›lda tekrarlayan düflme varl›¤› kaydedildi. Hastalar Leeds Nöropatik Semptom ve Bulgu De¤erlendirmesi ölçe¤ine göre nöropatik a¤r›s› olan ve olmayanlar olmak üzere iki gruba ayr›ld›. Depresyon de¤erlendirmede Geriatrik Depresyon Skalas›, günlük yaflam aktivitelerini de¤erlendirmede, Notthingham Geniflletilmifl Günlük Yaflam Aktiviteleri ‹ndeksi kullan›ld›. Bulgular: Çal›flmam›zda 62 (%26,4) hastada nöropatik a¤r› tespit edilmifltir. Geriatrik depresyon skorlar›, nöropatik a¤r›s› olan grupta 18,4±4,2 iken, nöropatik a¤r›s› olmayan grupta 12,5±3,7 idi. Bu fark istatistiksel olarak anlaml› bulundu (p=0,04). Her iki grup aras›nda günlük yaflam aktivite skorlar› aras›nda istatistiksel anlaml› fark bulunmam›flt›r. Nöropatik a¤r›s› olan grupta kronik hastal›k say›s›, devaml› kullan›lan ilaç say›s› ve son bir y›lda tekrarlayan düflme öyküsü varl›¤› istatistiksel olarak anlaml› oranda yüksek bulunmufltur (p=0,03, p=0,02, p=0,02). Sonuç: Geriatrik popülasyonda nöropatik a¤r› oldukça yüksek s›kl›kta görülmektedir. Özellikle ço¤ul kronik hastal›¤› olan yafll›larda nöropatik a¤r› sorulmal›, nöropatik a¤r› varl›¤›nda ise depresyon yönünden de¤erlendirme yap›lmal›d›r. Anahtar Sözcükler: Nöralji; Geriatri; Yafllanma; Depresyon; Günlük Yaflam Aktiviteleri. ABSTRACT