Miracle-dz/UniFAR-FTUs huggingface dataset:
The Heat Shock Protein 60 and Pap1 Participate in the Sporothrix schenckii-Host Interaction

Sporothrixschenckii is one of the etiological agents of sporotrichosis, a worldwide-distributed subcutaneous mycosis. Its cell wall contains a glycoconjugate composed of rhamnose, mannose, glucuronic acid, and proteins, named peptidorhamnomannan, which harbors important Sporothrix-specific immunogenic epitopes. Although the peptidorhamnomannan carbohydrate moiety has been extensively studied, thus far, little is known about the protein core. Here, using LC-MS/MS, we analyzed the S. schenckii peptidorhamnomannan peptide fraction and generated mass signals of 325 proteins, most of them likely to be moonlighting proteins. Among the identified proteins, chaperonin GroEL/Hsp60 and the uncharacterized protein Pap1 were selected for further analysis. Both proteins were heterologously expressed in bacteria, and they showed adhesive properties to the extracellular matrix proteins laminin, elastin, fibrinogen, and fibronectin, although Pap1 also was bound to type-I and type-II collagen. The inoculation of concentrations higher than 40 μg of these proteins, separately, increased immune effectors in the hemolymph of Galleria mellonella larvae and protected animals from an S. schenckii lethal challenge. These observations were confirmed when yeast-like cells, pre-incubated with anti-rHsp60 or anti-rPap1 antibodies were used to inoculate larvae. The animals inoculated with pretreated cells showed increased survival rates when compared to the control groups. In conclusion, we report that Hsp60 and Pap1 are part of the cell wall peptidorhamnomannan, can bind extracellular matrix components, and contribute to the S. schenckii virulence. To our knowledge, this is the first report about moonlighting protein in the S. schenckii cell wall with an important role during the pathogen–host interaction.
Agreement between Prehospital and Final Diagnosis in Patients with Acute Allergic Reactions: A Cross-Sectional Study

Introduction: Acute allergic reactions are usually first encountered in the prehospital setting and account for about 0.3% to 0.8% of prehospital runs in different countries. Right, and rapid recognition and treatment are necessary to decrease mortality and morbidity, especially in severe critical cases. This study evaluates the accuracy of prehospital care providers’ diagnosis in patients with acute allergic reactions in comparison with final (discharge) diagnosis as the gold standard. Methods: Patients who were transported to 2 urban referral hospitals between 2008 and 2014 under the dispatch code of “acute allergic reaction” were included in the study, retrospectively. Demographic data, etiology of an allergic reaction, clinical presentations, vital signs stability, and need for epinephrine injection were evaluated. The prehospital care providers’ diagnosis (documented on-call report) was compared with the final diagnosis (documented on discharge summary form). Results: A total of 300 patients were included in the study. In 55 (18.3%) cases the prehospital care providers’ and final diagnoses were different. Diagnoses were similar in 245 (81.6%) patients. Kappa coefficient was calculated as 0.621which shows a moderate-to-substantial agreement between prehospital and final diagnoses. Fifteen patients (5%) were discharged from the hospital with a diagnosis of anaphylaxis and only 4 cases (26.6%) were diagnosed in the prehospital setting. Conclusion: Although the overall agreement between prehospital and final diagnosis of acute allergic reactions calculated in this study was good, the accuracy of diagnosing the anaphylaxis (as the most critical allergic reaction with a potential fatality) was less than optimal.
Fuel Consumption Reduction in a Platoon: Experimental Results with two Electronically Coupled Trucks at Close Spacing

This paper presents the fuel consumption reduction experienced by two heavy-duty trucks driving at close spacing. The trucks were coupled without any mechanical contact using an "Electronic Tow Bar" developed within the European project PROMOTE-CHAUFFEUR at DaimlerChrysler. The experiments were carried out on a level test track with constant velocities and with spacing between 6 and 16 m. As expected from other studies, both trucks experienced a considerable fuel consumption reduction compared to drives in isolation. At a velocity of 80km/h and a spacing of 10 m the measured fuel consumption reduction was of about 21 percent for the trail truck which had a total weight of 28 t. An extrapolation of the results for other vehicle weights is also presented. For the covering abstract see ITRD E108169.
The Use of Anglicisms in the Field of Education: A Comparative Analysis of Romanian, German, and French

The era of globalization has led to frequent communication among people with different linguistic and cultural backgrounds, carried out usually in English, the modern lingua franca. English has influenced the languages of the world, which have started to borrow words in order to keep up with progress and internationalization. Anglicisms are used in almost every field, education being one of them. This paper highlights the presence of Anglicisms in the field of education, and focuses on a multilingual dictionary of education, from which it gathers a corpus in three different languages: Romanian, German, and French. The study aims to identify the Anglicisms employed in the educational field in the three languages aforementioned, and to analyze them comparatively, pointing out the similarities and differences among the languages in question.
Critical Timing Issues in Flash Thermography

In conventional flash thermography a pulse of light with a full width half maximum duration of 2–4 ms is applied to the surface of a solid sample and the surface temperature response is recorded with an infrared camera. Typically only the flash amplitude is adjusted, in order to minimize saturation of the camera array. However, a closer examination of the process indicates a more precise interrogation of the subsurface structure is obtained if the timing parameters of the excitation and the detector are carefully determined and controlled. In particular, limiting the pulse duration, the offset between the pulse and the detector integration time significantly increases correlation between modeled and experimental results during the early post‐flash frames. Additionally, a new method is described to precisely detect the initiation and duration of the pulse for common high end infrared cameras.
Human Milk Oligosaccharides as a Missing Piece in Combating Nutritional Issues during Exclusive Breastfeeding

Extensive studies have shown that breast milk is the best source of nutrition for infants, especially during the first six months, because it fulfills almost all of their nutritional needs. Among the many functional building blocks in breast milk, human milk oligosaccharides (HMOs) have been receiving more attention recently. Furthermore, it is the third most common group of compounds in human milk, and studies have demonstrated the health benefits it provides for infants, including improved nutritional status. HMOs were previously known as the ‘bifidus factor’ due to their ‘bifidogenic’ or prebiotic effects, which enabled the nourishment of the gastrointestinal microbiota. Healthy gastrointestinal microbiota are intestinal health substrates that increase nutrient absorption and reduce the incidence of diarrhea. In addition, HMOs, directly and indirectly, protect infants against infections and strengthen their immune system, leading to a positive energy balance and promoting normal growth. Non-modifiable factors, such as genetics, and modifiable factors (e.g., maternal health, diet, nutritional status, environment) can influence the HMO profile. This review provides an overview of the current understanding of how HMOs can contribute to the prevention and treatment of nutritional issues during exclusive breastfeeding.
Analytical solution for determining the required strength of a side-exposed mine backfill containing a plug

Backfilling is well known in the mining industry. A basic issue associated with mine backfill design is the determination of the strength of the backfill required to maintain the stability of the backfill body upon removal of a side wall when an adjacent secondary stope is excavated. This task is usually accomplished using a solution proposed by Mitchell et al. in the early 1980s. Recently, this solution has been reviewed and a modified solution has been proposed. These existing solutions, however, were developed for a uniform backfill. In practice, mine stopes are usually divided into primary and secondary stopes. Primary stopes are often backfilled in two stages: a plug pour and a final pour. In many cases, the cement content of the plug pour is higher than that of the final pour. The positive effect of the stronger plug is neglected in both the original and the modified Mitchell et al. solutions. Here, a new analytical solution is developed for estimating the required strength of a laterally exposed ba.
Enabling Knowledge Creation: How to Unlock the Mystery of Tacit Knowledge and Release the Power of Innovation

When The Knowledge-Creating Company (OUP; nearly 40,000 copies sold) appeared, it was hailed as a landmark work in the field of knowledge management. Now, Enabling Knowledge Creation ventures even further into this all-important territory, showing how firms can generate and nurture ideas by using the concepts introduced in the first book. Weaving together lessons from such international leaders as Siemens, Unilever, Skandia, and Sony, along with their own first-hand consulting experiences, the authors introduce knowledge enabling-the overall set of organizational activities that promote knowledge creation-and demonstrate its power to transform an organization's knowledge into value-creating actions. They describe the five key "knowledge enablers" and outline what it takes to instill a knowledge vision, manage conversations, mobilize knowledge activists, create the right context for knowledge creation, and globalize local knowledge. The authors stress that knowledge creation must be more than the exclusive purview of one individual-or designated "knowledge" officer. Indeed, it demands new roles and responsibilities for everyone in the organization-from the elite in the executive suite to the frontline workers on the shop floor. Whether an activist, a caring expert, or a corporate epistemologist who focuses on the theory of knowledge itself, everyone in an organization has a vital role to play in making "care" an integral part of the everyday experience; in supporting, nurturing, and encouraging microcommunities of innovation and fun; and in creating a shared space where knowledge is created, exchanged, and used for sustained, competitive advantage. This much-anticipated sequel puts practical tools into the hands of managers and executives who are struggling to unleash the power of knowledge in their organization.
Early Warning System for Online STEM Learning—A Slimmer Approach Using Recurrent Neural Networks

While the use of deep neural networks is popular for predicting students’ learning outcomes, convolutional neural network (CNN)-based methods are used more often. Such methods require numerous features, training data, or multiple models to achieve week-by-week predictions. However, many current learning management systems (LMSs) operated by colleges cannot provide adequate information. To make the system more feasible, this article proposes a recurrent neural network (RNN)-based framework to identify at-risk students who might fail the course using only a few common learning features. RNN-based methods can be more effective than CNN-based methods in identifying at-risk students due to their ability to memorize time-series features. The data used in this study were collected from an online course that teaches artificial intelligence (AI) at a university in northern Taiwan. Common features, such as the number of logins, number of posts and number of homework assignments submitted, are considered to train the model. This study compares the prediction results of the RNN model with the following conventional machine learning models: logistic regression, support vector machines, decision trees and random forests. This work also compares the performance of the RNN model with two neural network-based models: the multi-layer perceptron (MLP) and a CNN-based model. The experimental results demonstrate that the RNN model used in this study is better than conventional machine learning models and the MLP in terms of F-score, while achieving similar performance to the CNN-based model with fewer parameters. Our study shows that the designed RNN model can identify at-risk students once one-third of the semester has passed. Some future directions are also discussed.
Transcriptomic Studies Suggest a Coincident Role for Apoptosis and Pyroptosis but Not for Autophagic Neuronal Death in TBEV-Infected Human Neuronal/Glial Cells

Tick-borne encephalitis virus (TBEV), a member of the Flaviviridae family, Flavivirus genus, is responsible for neurological symptoms that may cause permanent disability or death. With an incidence on the rise, it is the major arbovirus affecting humans in Central/Northern Europe and North-Eastern Asia. Neuronal death is a critical feature of TBEV infection, yet little is known about the type of death and the molecular mechanisms involved. In this study, we used a recently established pathological model of TBEV infection based on human neuronal/glial cells differentiated from fetal neural progenitors and transcriptomic approaches to tackle this question. We confirmed the occurrence of apoptotic death in these cultures and further showed that genes involved in pyroptotic death were up-regulated, suggesting that this type of death also occurs in TBEV-infected human brain cells. On the contrary, no up-regulation of major autophagic genes was found. Furthermore, we demonstrated an up-regulation of a cluster of genes belonging to the extrinsic apoptotic pathway and revealed the cellular types expressing them. Our results suggest that neuronal death occurs by multiple mechanisms in TBEV-infected human neuronal/glial cells, thus providing a first insight into the molecular pathways that may be involved in neuronal death when the human brain is infected by TBEV.
Penentuan Prioritas Pengembangan Infrastruktur Kawasan Wisata Bahari Di Desa Sumberejo, Desa Lojejer, Dan Desa Puger Kulon, Kabupaten Jember Berdasarkan Preferensi Pengunjung Dan Masyarakat

Kabupaten Jember memiliki kawasan wisata bahari dengan lima pantai yang berkarakteristik berbeda-beda pada ODTW yang dimiliki. Pantai Watu Ulo, Pantai Papuma, dan Pantai Puger memiliki jumlah pengunjung yang mengalami peningkatan setiap tahunnya dan merupakan penyumbang kontribusi terbesar pada jumlah wisatawan di Kabupaten Jember. Akan tetapi hal tersebut tidak diimbangi dengan adanya infrastruktur kawasan wisata yang memadai untuk mendukung kegiatan wisata di dalamnya . Penelitian ini dilakukan untuk menganalisa prioritas pengembangan infrastruktur berdasarkan preferensi pengunjung dan masyarakat melalui tingkat kepentingan dan kinerja infrastruktur kawasan wisata bahari dengan teknik IPA ( Importance-Performance Analysis ) . Hasil dari penelitian ini adalah berupa prioritas pengembangan infrastruktur dalam mendukung kegiatan wisata bahari di Kabupaten Jember . Infrastruktur yang menjadi prioritas pengembangan di kawasan wisata bahari Kabupaten Jember adalah kondisi jalan, moda transportasi, fasilitas pendukung transportasi, sarana rekreasi, dan fasilitas pelayanan kesehatan.
Job Hopping - A Review of Literature

The problem of job hopping has been researched upon by a number of researchers in diverse fields. In the different sectors, which contribute to form a major chunk of a country’s GDP, and, claims to provide employment to a major part of the workforce, it is pertinent, therefore, to analyze the factors which lead to the employees’ disengagement from these sectors. Further, with the increasing permeability of boundaries on the global front, thanks to neo-liberalisation waves, the cross-occupational and cross-organizational mobility of the employees has witnessed a phenomenal growth. Concurrent with the job hopping of the employees is the attempt by the organizations to bring in practices which might help in the retention of the employees in a bid to offset the damages of the rising attrition. The present paper is one such attempt at reviewing the literature of the concept of job hopping and retention.
On-Chip Communication Architectures: System on Chip Interconnect

Over the past decade, system-on-chip (SoC) designs have evolved to address the ever increasing complexity of applications, fueled by the era of digital convergence. Improvements in process technology have effectively shrunk board-level components so they can be integrated on a single chip. New on-chip communication architectures have been designed to support all inter-component communication in a SoC design. These communication architecture fabrics have a critical impact on the power consumption, performance, cost and design cycle time of modern SoC designs. As application complexity strains the communication backbone of SoC designs, academic and industrial R&D efforts and dollars are increasingly focused on communication architecture design. This book is a comprehensive reference on concepts, research and trends in on-chip communication architecture design. It will provide readers with a comprehensive survey, not available elsewhere, of all current standards for on-chip communication architectures. KEY FEATURES * A definitive guide to on-chip communication architectures, explaining key concepts, surveying research efforts and predicting future trends * Detailed analysis of all popular standards for on-chip communication architectures * Comprehensive survey of all research on communication architectures, covering a wide range of topics relevant to this area, spanning the past several years, and up to date with the most current research efforts * Future trends that with have a significant impact on research and design of communication architectures over the next several years
Anti-Yeast Synergistic Effects and Mode of Action of Australian Native Plant Essential Oils

Yeasts are the most common group of microorganisms responsible for spoilage of soft drinks and fruit juices due to their ability to withstand juice acidity and pasteurization temperatures and resist the action of weak-acid preservatives. Food industries are interested in the application of natural antimicrobial compounds as an alternative solution to the spoilage problem. This study attempts to investigate the effectiveness of three Australian native plant essential oils (EOs) Tasmanian pepper leaf (TPL), lemon myrtle (LM) and anise myrtle (AM) against weak-acid resistant yeasts, to identify their major bioactive compounds and to elucidate their anti-yeast mode of action. The minimum inhibitory concentration (MIC), minimum fungicidal concentration (MFC) and minimum bactericidal concentration (MBC) were assessed for EOs against weak-acid resistant yeasts (Candida albicans, Candida krusei, Dekkera anomala, Dekkera bruxellensis, Rhodotorula mucilaginosa, Saccharomyces cerevisiae, Schizosaccharomyces pombe, Zygosaccharomyces bailii and Zygosaccharomyces rouxii) and bacteria (Staphylococcus aureus and Escherichia coli). The EOs showed anti-yeast and antibacterial activity at concentrations ranging from 0.03–0.07 mg/mL and 0.22–0.42 mg/mL for TPL and 0.07–0.31 mg/mL and 0.83–1.67 mg/mL for LM, respectively. The EOs main bioactive compounds were identified as polygodial in TPL, citral (neral and geranial) in LM and anethole in AM. No changes in the MICs of the EOs were observed in the sorbitol osmotic protection assay but were found to be increased in the ergosterol binding assay after the addition of exogenous ergosterol. Damaging of the yeast cell membrane, channel formation, cell organelles and ion leakage could be identified as the mode of action of TPL and LM EOs. The studied Australian native plant EOs showed potential as natural antimicrobials that could be used in the beverage and food industry against the spoilage causing yeasts.
Incidence of Heart Diseases in Children with Cleft Lip and Cleft Palate

Introduction: Cleft lip and cleft palate are one of the most common craniofacial malformations that occur in children. Congenital heart diseases are more prevalent among children with cleft lip and cleft palate. Early intervention is necessary to improve the survival and for proper development of children. Materials and Methods: A retrospective study is conducted at Paediatrics Department in Saveetha medical College for a period of one year. In the present study medical records of patients with cleft lip and palate are evaluated and analysed for the incidence of heart diseases. Results: In the present study medical records of patients with cleft lip and palate are evaluated and analysed for the incidence of heart diseases. Out of 163 children with cleft lip and cleft palate, 56 children (71.42% male and 28.57% female) had cleft lip, 30 children (66.66% male and 33.33% female) had cleft palate, 77 children (66.23% male and 33.76% female) had both cleft lip and cleft palate.VSD is reported as the most common cardiac anomaly (42.86%) in children with cleft lip and cleft palate. Conclusion: There is an increased incidence of congenital heart diseases in children with cleft lip and cleft palate. Echocardiography is an important investigation done for early identification and proper management.
Borrelioses in Brazil: Is it time to consider tick-borne relapsing fever a neglected disease in Brazil?

[1]. University of Texas Medical Branch, Department of Pathology, Galveston TX, USA. [2]. Asociación Colombiana de Infectología, Committee of Tropical Medicine, Zoonoses and Travel Medicine, Bogotá, Colombia. [3]. Universidad de Concepción, Facultad de Ciencias Veterinarias, Departamento de Ciencia Animal, Chillán, Ñuble, Chile. [4]. Universidade de São Paulo, Faculdade de Medicina Veterinária e Zootecnia, Departamento de Medicina Veterinária Preventiva e Saúde Animal, São Paulo, SP, Brasil. [5]. Universidade Estadual de Campinas, Hospital de Clínicas, Seção de Epidemiologia Hospitalar, Campinas, SP, Brasil.