Miracle-dz/UniFAR-FTUs huggingface dataset:
Asiatic Acid Inhibits Nasopharyngeal Carcinoma Cell Viability and Migration via Suppressing STAT3 and Claudin-1

Nasopharyngeal carcinoma (NPC) is a prevalent cancer in Southeast Asia, but effective treatment options remain limited, and chemotherapy has a high resistance rate. Asiatic acid (AA), a triterpenoid found in Centella asiatica, has shown anticancer activity in various cancers. Therefore, this study aims to investigate the anticancer effects and mechanisms of AA in NPC cell lines. The effects of AA on NPC cytotoxicity, apoptosis, and migration were determined in TW-01 and SUNE5-8F NPC cell lines. Western blot analysis was performed to evaluate the protein expression levels affected by AA. The role of AA in proliferation and migration was investigated in STAT3 and claudin-1 knockdown cells. AA inhibited NPC cell viability and migration and induced cell death by increasing cleaved caspase-3 expression. Moreover, AA inhibited STAT3 phosphorylation and reduced claudin-1 expression in NPC cells. Although knockdown of STAT3 or claudin-1 slightly reduced cell viability, it did not enhance the anti-proliferative effect of AA. However, knockdown of STAT3 or claudin-1 increased the anti-migratory effect of AA in NPC cells. These results suggest that AA can be a promising candidate for drug development against NPC.
Natural Products for the Immunotherapy of Glioma

Glioma immunotherapy has attracted increasing attention since the immune system plays a vital role in suppressing tumor growth. Immunotherapy strategies are already being tested in clinical trials, such as immune checkpoint inhibitors (ICIs), vaccines, chimeric antigen receptor T-cell (CAR-T cell) therapy, and virus therapy. However, the clinical application of these immunotherapies is limited due to their tremendous side effects and slight efficacy caused by glioma heterogeneity, antigen escape, and the presence of glioma immunosuppressive microenvironment (GIME). Natural products have emerged as a promising and safe strategy for glioma therapy since most of them possess excellent antitumor effects and immunoregulatory properties by reversing GIME. This review summarizes the status of current immunotherapy strategies for glioma, including their obstacles. Then we discuss the recent advancement of natural products for glioma immunotherapy. Additionally, perspectives on the challenges and opportunities of natural compounds for modulating the glioma microenvironment are also illustrated.
Student Adaptation, Loneliness and Mental Health Profiles during the Second Wave of the Pandemic COVID-19

Since the COVID-19 pandemic, adolescent mental health difficulties have increased. To understand adolescent adjustment, it is important to explore both mental health difficulties and indicators of resilience and well-being. The primary aim of this study was to explore the associations among resilience, subjective well-being (SWB), fear of COVID-19, and loneliness among adolescents during the second wave of the pandemic. Additionally, the study aimed to identify student profiles based on these variables. The sample consisted of 469 high school students (61% girls, 29% junior high school). Resilience was positively correlated with SWB and negatively with fear of COVID-19 and loneliness. Three student profiles were identified. The Resilient and Satisfied group (38%) consisted of students with the most positive adaptation, and the Average group (41%) involved students with middle scores in all variables, while the Vulnerable and Distressed group (21%) included those who struggled the most. The need for a tiered approach in providing school-based mental health support is discussed.
Abelmoschus eculentus Seed Extract Exhibits In Vitro and In Vivo Anti-Alzheimer’s Potential Supported by Metabolomic and Computational Investigation

Abelmoschus esculentus Linn. (okra, F. Malvaceae) is a fruit widely consumed all over the world. In our study, the anti-Alzheimer’s potential of A. esculentus was evaluated. An in vitro DPPH free radical assay on A. esculentus seed’s total extract and AChE inhibition potential screening indicated a significant anti-Alzheimer’s activity of the extract, which was confirmed through an in vivo study in an aluminum-intoxicated rat model. Additionally, in vivo results demonstrated significant improvement in Alzheimer’s rats, which was confirmed by improving T-maze, beam balance tests, lower serum levels of AChE, norepinephrine, glycated end products, IL-6, and MDA. The levels of dopamine, BDNF, GSH, and TAC returned to normal values during the study. Moreover, histological investigations of brain tissue revealed that the destruction in collagen fiber nearly returns back to the normal pattern. Metabolomic analysis of the ethanolic extract of A. esculentus seeds via LC–HR-ESI-MS dereplicated ten compounds. A network pharmacology study displayed the relation between identified compounds and 136 genes, among which 84 genes related to Alzheimer’s disorders, and focused on AChE, APP, BACE1, MAPT and TNF genes with interactions to all Alzheimer’s disorders. Consequently, the results revealed in our study grant potential dietary elements for the management of Alzheimer’s disorders.
Antecedent Factor Model of Entrepreneurial Orientation in Improving Marketing Performance through Product Innovation and Value Co-Creation

This research analyzes marketing performance improvement models through product innovation and value co-creation toward food security during the covid-19 pandemic. The main problem is based on the low-performance level of MSMEs of culinary products in Banten. The SEM method uses a SmartPLS v. 3.0 application software to conduct analysis. The population is MSMEs culinary business actors in the area of Banten Province. The probability/random sampling technique will be applied with the cluster method, and the number to be analyzed is 90 respondents. The results showed that marketing orientation directly and significantly affects marketing performance. Furthermore, marketing orientation does not significantly impact marketing performance through product innovation. It significantly influences marketing performance on the alpha level of 10% through value co-creation and product innovation. Therefore, value co-creation has a crucial role in the relationship among variables in this research.
On the periodic injection of fluid into, and its extraction from, a confined aquifer

Abstract We consider the periodic injection and extraction of fluid from a line well in a horizontal saturated aquifer of finite thickness as part of an aquifer thermal energy storage system. We focus on the case in which the injected fluid is dense relative to the original fluid in the aquifer and we explore the competition between the driving pressure and buoyancy force in controlling the dispersal of the injected fluid through the aquifer. We show that, after each cycle, a progressively larger fraction of the injected fluid is extracted, while the remainder of the injected fluid gradually migrates away from the well such that, after time $\def \xmlpi #1{}\def \mathsfbi #1{\boldsymbol {\mathsf {#1}}}\let \le =\leqslant \let \leq =\leqslant \let \ge =\geqslant \let \geq =\geqslant \def \Pr {\mathit {Pr}}\def \Fr {\mathit {Fr}}\def \Rey {\mathit {Re}}t$ , the position of the leading edge of the injected fluid, $x_{nose}(t)$ , scales as $ x_{nose}(t)\sim x_{nose}(\tau )\sqrt{t/\tau }$ , where $\tau $ is the period of injection. If the fluid is extracted from the base of the layer, then, near the well, the thickness of the injected fluid at the end of the extraction cycle tends to a constant value, which decreases with injection rate. We also show that there is a class of self-similar exchange-flow solutions that develop when a saturated porous layer of thickness $H$ is in contact with a stratified fluid reservoir, filled to thickness $F_0H<H$ with relatively dense fluid, and with original reservoir fluid above this level. We show that these solutions coincide exactly with the far-field flow produced by the injection–extraction cycles. We successfully test the models with a series of analogue experiments of both the injection–extraction flow and the exchange flow using a Hele-Shaw cell. In the case that the fluid is injected and extracted from the top of the aquifer, the value $F_0$ tends to unity in all cases, although the convergence time depends on the rate and period of injection, the buoyancy speed and the vertical extent and the porosity of the aquifer. We use the model to explore how the concentration of reservoir fluid in the produced fluid varies as the system evolves from cycle to cycle, and we also examine the time required to transport a localised but distant contaminant to the production well through the far-field exchange flow. Finally, we consider the analogous axisymmetric injection–extraction flow problem, and show, through both numerical solution of the governing equations and experiment, that, although there is no simple class of similarity solutions, the fraction of injected fluid that is extracted progressively increases in each cycle.
Precarious Job and Union Tendencies among Women and Young Employees: The Relationships between Economic Constraints, Job Security and Trust in Employers

The aim of this study is to examine whether having a precarious job (low job security) increases union tendencies among female workers and young workers. The study examines the relationship between economic constraints, trust in employers and union attitudes in terms of gender and age in the context of the antecedents and consequences of job security. Data were collected using a survey conducted among 804 Turkish employees working in various sectors and analysed through multi-group path models, t-tests and ANOVA to measure job security objectively and subjectively. Economic constraints increase the acceptance of low job security and decrease trust towards employers. The research also indicates that poorer job security does not affect collective and union tendencies. While precarious jobs are more intense among young and women employees, there is no difference in their union tendencies. This article used the decent work perspective to explore the consequences of having a precarious job among women and young workers in Turkey. We assumed that the perception of precariousness reduces trust towards employers and strengthens collective and union tendencies. We also argue that economic constraints play an important role in choosing precarious jobs. We also test whether women and young employees, as two prominent disadvantaged groups, have collective efficacy and union efficacy in precarious job conditions.
Integrated Bioinformatics Analysis and Experimental Verification of Immune Cell Infiltration and the Related Core Genes in Ulcerative Colitis

Background Ulcerative colitis is a recurrent autoimmune disease. At present, the pathogenesis of UC is not completely clear. Hence, the etiology and underlying molecular mechanism need to be further investigated. Methods Three sets of microarray datasets were included from the Gene Expression Omnibus database. The differentially expressed genes in two sets of datasets were analyzed using the R software, and the core genes of UC were screened using machine learning. The sensitivity and specificity of the core genes were evaluated with the receiver operating characteristic curve in another microarray dataset. Subsequently, the CIBERSORT tool was used to analyze the relationship between UC and its core genes and immune cell infiltration. To verify the relationship between UC and core genes and the relationship between core genes and immune cell infiltration in vivo. Results A total of 36 DEGs were identified. AQP8, HMGCS2, and VNN1 were determined to be the core genes of UC. These genes had high sensitivity and specificity in receiver operating characteristic curve analysis. According to the analysis of immune cell infiltration, neutrophils, monocytes, and macrophages were positively correlated with UC. AQP8, HMGCS2, and VNN1 were also correlated with immune cell infiltration to varying degrees. In vivo experiments verified that the expressions of neutrophils, monocytes, and macrophages increased in the UC colon. Furthermore, the expressions of AQP8 and HMGCS2 decreased, whereas that of VNN1 increased. Azathioprine treatment improved all the indicators to different degrees. Conclusion AQP8, HMGCS2, and VNN1 are the core genes of UC and exhibit different degrees of correlation with immune cells. These genes are expected to become new therapeutic targets for UC. Moreover, the occurrence and development of UC are influenced by immune cell infiltration.
The APM galaxy survey. II Photometric corrections.

L'article anterieur de Maddox S.J. et al. (1990, Mon.Not.R.astr.Soc., 243) presentait quelques aspects fondamentaux du survey APM (Automatic Plate Measuring), les parametres mesures par APM, et l'algorithme de classification etoile-galaxie. Les methodes qui ont ete utilisees pour etablir la photometrie precise dans un survey de 2 millions de galaxies plus brillantes que b J = 20.5 couvrant plus de 4300 degres carres de la calotte galactique sud sont presentees.
Exploring the Effects of the Procedural Justice of Downsizing on Survivors' Behaviour

Downsizing is seen as a commonly chosen strategy to improve organizational efficiency, effectiveness, performance, competitiveness, and to regain financial stability. After the decision on the downsizing was made and the downsizing was conducted, special attention should be placed on those employees who survived the downsizing. The purpose of this paper is to observe how the procedural fairness of the downsizing method applied impacts the survivers' behaviour. The primary assumption is that the characteristics of the employed downsizing method, here observed Clarity, Validity, and Accuracy, impact the attitudes of survivors viewed through Motivation, Satisfaction, and Turnover Intention. A questionnaire was developed and distributed to 556 employees who had survived downsizing to verify the proposed conceptual model. The results of the study supported the claim that characteristics of the downsizing method influence the survivors' behaviour, whereas Validity stands out for its relatively strong impact on Motivation and Satisfaction with the organisation to which the survivors belong. The findings illustrate that when conducting downsizing, managers and decision makers should consider the fairness of downsizing method applied because, if conducted in an adequate manner, dowsizing can even induce positive behavior of the surviving members.
Intention to Visit Sustainable Tourism Destination After Covid 19 Pandemic

This paper aims to investigate the antecedents of environmental attitude and its influence on intention to visit sustainable tourism destination, which is moderated by individual green value. Purposive sampling method was used to collect the data from 370 respondents. The data was analysed using structural equation model. Out of the four antecedents, environmental identity and enjoyment of nature positively influence environmental attitude that leads to intention to visit. Results also showed that individual green value moderates the influence of environmental attitude on intention to visit sustainable tourism destination. This research suggests sustainable tourism marketers to create message that form positive environmental attitude. This study offers a conceptual model that focusing on environmental attitude as a key variable that is widely proven to be the best predictor of intention.
Morpho-physiological and biochemical attributes as tools to screen tolerance and susceptible rice cultivars for drought stress

Present research work was aimed to observe possible changes in the metabolism of rice plants (Oryza sativa L.) through drought stress. Rice belongs to the family Poaceae. It is considered as a vital food crop across all the major countries worldwide. Rice is prone to be affected by drought stress. Therefore, developing the drought tolerant cultivars of cereal crops assumed considerable importance. This work was carried out with an objective to study the Screening of rice cultivars against water stress and compare biochemical characteristic among different drought tolerant and sensitive rice cultivars. A set of 25 cultivars of rice were screened against drought stress at vegetative stage through various morpho-physiological characters such as moisture, relative water content (RWC), membrane stability index(MSI), membrane injury(MI), seedling length and seedling weight. The RWC is a best criterion for plant water status. The osmotic adjustment is a influential mechanism of conserving cellular hydration under water stress and RWC expression also affects osmotic adjustment in this respect. Thus, it can be considered that the higher RWC having cv. GAR-13 and NWGR-16026 were tolerant and lower RWC having cv. NWGR-16009 and NWGR-16019 were susceptible. Hence, cv. GAR-13 & NWGR-16026 was used as tolerant and NWGR-16009 & NWGR-16019 were used as susceptible. On the basis of first experiment total four cultivars (Two tolerant NWGR-16026 & GAR-13, two susceptible NWGR-16009 & NWGR-16019) were selected for various biochemical analysis. The results indicated that total soluble sugars (TSS), glycine betaine and ascorbic acid content were found significantly higher in cultivar NWGR-16026. The proline content was found significantly higher in cultivar GAR-13. So, RWC and some biochemical parameters are best indicators for selection regarded as potentially useful for drought tolerant rice cultivars and targets for development through transgenic approaches.
Increasing pressure on US men for income in order to find a spouse

ABSTRACT In contemporary societies, social status – especially income – is one of the most important determinants of ever marrying among men. Using U.S. census data, we estimated the importance of income for ever marrying among men and women, analyzing birth cohorts from 1890 to 1973. We examined individuals between the ages of 45 and 55, a total of 3.5 million men and 3.6 million women. We find that for men, the importance of income in predicting ever being married increased steadily over time. Income predicted only 2.5% of the variance in ever marrying for those born in 1890–1910, but about 20% for the 1973 cohort. For women, the opposite is true: the higher a woman’s income among those born between 1890 and 1910, the lower her odds of ever being married, explaining 6% of the variance, whereas today a woman’s income no longer plays a role in ever being married. Thus, our results provide evidence that income may represent a very recent selection pressure on men in the US, a pressure that has become increasingly stronger over time in the 20th and early 21st centuries.
Antagonistic activity of selected macromycetes against two harmful micromycetes.

Competition between 31 macromycete species and two harmful micromycetes Aspergillus niger and Penicillium polonicum was evaluated using dual-culture plate assay. All investigated fungi, except for Inonotus obliquus and Lepista luscina, possessed different levels of antagonistic activity against the tested micromycetes. Hypsizygus marmoreus and Lyophyllum shimeji were inactive against A. niger. Morchella esculenta and Oxyporus obducens were passive in the case of co-growth with P. polonicum. The study of fungal interactions showed variability in types of reactions and level of their visualisation. Co-cultivation of the studied species resulted in the following reactions: deadlock after mycelial contact and at a distance, partial or complete replacement after initial deadlock on contact. In general, the studied macromycetes showed moderate activity against the two micromycetes, as 11 species showed active and 7 species moderate antagonism. Results revealed higher antagonistic activity of macromycetes against P. polonicum than in A. niger co-cultures. Wood-decaying species Ganoderma lucidum and Trametes versicolor were the most active fungi against the two tested micromycetes with a maximal antagonism index. These findings provide valuable insights which can be further explored by means of in vivo assays to find a suitable agent for the biocontrol of diseases or spoilage caused by A. niger and P. polonicum.
New insight into tuning magnetic phases of RMn6Sn6 kagome metals

Kagome metals with magnetic order offer the possibility of tuning topological electronic states via external control parameters such as temperature or magnetic field. ErMn$_6$Sn$_6$ (Er$166$) is a member of a group of $R166$, $R=$~rare earth, compounds hosting ferromagnetic Mn kagome nets whose magnetic moment direction and layer-to-layer magnetic correlations are strongly influenced by coupling to $R$ magnetic moments in neighboring triangular layers. Here, we use neutron diffraction and magnetization data to examine the temperature-driven transition in Er$166$ from a planar-ferrimagnetic to distorted-triple-spiral magnetic order. These data inform mean-field calculations which highlight the fragile, tunable nature of the magnetism caused by competing Mn-Mn and Mn-Er interlayer magnetic exchange couplings and Mn and Er magnetic anisotropies. This competition results in the near degeneracy of a variety of collinear, non-collinear, and non-coplanar magnetic phases which we show are readily selected and adjusted via changing temperature or magnetic field. Thermal fluctuations of the Er moment direction provide the key to this tunability.
An Agnostic View on the Cost of Overfitting in (Kernel) Ridge Regression

We study the cost of overfitting in noisy kernel ridge regression (KRR), which we define as the ratio between the test error of the interpolating ridgeless model and the test error of the optimally-tuned model. We take an"agnostic"view in the following sense: we consider the cost as a function of sample size for any target function, even if the sample size is not large enough for consistency or the target is outside the RKHS. We analyze the cost of overfitting under a Gaussian universality ansatz using recently derived (non-rigorous) risk estimates in terms of the task eigenstructure. Our analysis provides a more refined characterization of benign, tempered and catastrophic overfitting (cf. Mallinar et al. 2022).
Shape-Constraint Recurrent Flow for 6D Object Pose Estimation

Most recent 6D object pose methods use 2D optical flow to refine their results. However, the general optical flow methods typically do not consider the target's 3D shape information during matching, making them less effective in 6D object pose estimation. In this work, we propose a shape-constraint recurrent matching framework for 6D object pose estimation. We first compute a pose-induced flow based on the displacement of 2D reprojection between the initial pose and the currently estimated pose, which embeds the target's 3D shape implicitly. Then we use this pose-induced flow to construct the correlation map for the following matching iterations, which reduces the matching space significantly and is much easier to learn. Further-more, we use networks to learn the object pose based on the current estimated flow, which facilitates the computation of the pose-induced flow for the next iteration and yields an end-to-end system for object pose. Finally, we optimize the optical flow and object pose simultaneously in a recurrent manner. We evaluate our method on three challenging 6D object pose datasets and show that it outperforms the state of the art significantly in both accuracy and efficiency.