Miracle-dz/UniFAR-FTUs huggingface dataset:
An Integrative Review of How Healthcare Organizations Can Support Hospital Nurses to Thrive at Work

Background: Solutions that address the anticipated nursing shortage should focus on thriving at work: a positive psychological state characterized by a sense of vitality and learning, resulting in higher levels of work engagement, commitment, and wellbeing. Purpose: To synthesize international evidence on organizational factors that support hospital nurse wellbeing and to identify how the Social Embeddedness of Thriving at Work Model can support health managers to develop management approaches that enable nurses to thrive. Method: Conduct an integrative review of literature published between 2005–2019. Results: Thematic analysis identified five key themes: (1) Empowerment; (2) Mood of the organization; (3) An enabling environment; (4) Togetherness with colleagues; and (5) Leaders’ connectivity. Conclusions: The Social Embeddedness of Thriving at Work Model supports managers to develop management approaches that enable their nurses to thrive. Health managers should consider strategies to support nurses to thrive at work to improve nurse work engagement and wellbeing.
PENGARUH pH PADA ADSORPSI KATION UNSUR HARA Ca2+ DAN K+ OLEH SILIKA DARI LUMPUR LAPINDO

The aim of this research was to determine the effect of pH on the adsorption of micronu- trients of Ca 2+ and K . by silica from lapindo mud. Data were collected by the adsorption experiments, on which 3 grams of silica separated from Lapindo mudwere dissolved in 300 mL of 0.0001 or 0.001 M Ca + 2+ or K . , and stirred for 2 hours. The pH of suspension was varied and left for equilibrate for 2 hours, and a sample was taken and measured for free concentration of K + + . cation using Flame Atomic Emission Spectroscopy and of Ca using Atomic Absorption Spectroscopy (AAS). The pH ranges were from 3 to 10. Temperature o 30 C and contact time of 2 hours were maintained. The research showed that both cations were adsorbed in sigmoid curve, increased with increasing pH values. In entire ranges of observed pH, the percentage of cations adsorbed by silica was not different signiﬁ cantly. The adsorbent of silica formed silanol (SiOH) in water. The –OH groups of silica were pro tonated forming SiOH o at lower pH and deprotonated forming SiO¯ at higher pH. Wether Ca 2+ or K + 2 + . cations were bound to silica surfacesvia cation exchange reactions, on which Ca 2+ or K + . exchanged H of SiOH using one charge of the cations, forming [SiO(CaO)] for Ca 2+ , and [SiO-K] for K
Adult Spinal Deformity: Current Concepts and Decision-Making Strategies for Management

Adult spinal deformity (ASD) is characterized by three-dimensional abnormalities of the thoracic or thoracolumbar spine that exerts significant impacts on the health-related quality of life (HRQoL). With the important effects that deformity of the sagittal plane exerts on the HRQoL, there have been paradigm shifts in ASD evaluation and management. Loss of lumbar lordosis is recognized as a key driver of ASD followed by reducing kyphosis, pelvic retroversion, and knee flexion. The Scoliosis Research Society (SRS)– Schwab classification reflects the sagittal spinopelvic parameters that correlate pain and disability in ASD patients. Although the SRS–Schwab classification provides a realignment target framework for surgeons, a structured patient-specific systemic approach is crucial for the process of decision-making. ASD management should be focused on restoring age-specific harmonious alignment and should consider the comorbidities and risk factors of each patient to prevent catastrophic complications and enhance the HRQoL.
MicroRNA, Diabetes Mellitus and Colorectal Cancer

Diabetes mellitus (DM) is an endocrinological disorder that is due to either the pancreas not producing enough insulin, or the body does not respond appropriately to insulin. There are many complications of DM such as retinopathy, nephropathy, and peripheral neuropathy. In addition to these complications, DM was reported to be associated with different cancers. In this review, we discuss the association between DM and colorectal cancer (CRC). CRC is the third most commonly diagnosed cancer worldwide that mostly affects older people, however, its incidence and mortality are rising among young people. We discuss the relationship between DM and CRC based on their common microRNA (miRNA) biomarkers. miRNAs are non-coding RNAs playing important functions in cell differentiation, development, regulation of cell cycle, and apoptosis. miRNAs can inhibit cell proliferation and induce apoptosis in CRC cells. miRNAs also can improve glucose tolerance and insulin sensitivity. Therefore, investigating the common miRNA biomarkers of both DM and CRC can shed a light on how these two diseases are correlated and more understanding of the link between these two diseases can help the prevention of both DM and CRC.
Efficacy of Tocilizumab Monotherapy Versus Tocilizumab and Methotrexate Combination Therapy in the Prevention of Radiographic Progression in Rheumatoid Arthritis: An Analysis Using Individual Patient Data From Multiple Clinical Trials

To compare the effects of preventing radiographic progression (in its 3 components) of tocilizumab (TCZ) monotherapy with those of TCZ and methotrexate (MTX) in combination therapy (TCZ + MTX), and to evaluate possible effect modifiers in this model.
Viral nucleoprotein antibodies activate TRIM21 and induce T cell immunity

Nucleoprotein (N) is an immunodominant antigen in many enveloped virus infections. While the diagnostic value of anti‐N antibodies is clear, their role in immunity is not. This is because while they are non‐neutralising, they somehow clear infection by coronavirus, influenza and LCMV in vivo. Here, we show that anti‐N immune protection is mediated by the cytosolic Fc receptor and E3 ubiquitin ligase TRIM21. Exploiting LCMV as a model system, we demonstrate that TRIM21 uses anti‐N antibodies to target N for cytosolic degradation and generate cytotoxic T cells (CTLs) against N peptide. These CTLs rapidly eliminate N‐peptide‐displaying cells and drive efficient viral clearance. These results reveal a new mechanism of immune synergy between antibodies and T cells and highlights N as an important vaccine target.
Peripheral Glycolysis in Neurodegenerative Diseases

Neurodegenerative diseases are a group of nervous system conditions characterised pathologically by the abnormal deposition of protein throughout the brain and spinal cord. One common pathophysiological change seen in all neurodegenerative disease is a change to the metabolic function of nervous system and peripheral cells. Glycolysis is the conversion of glucose to pyruvate or lactate which results in the generation of ATP and has been shown to be abnormal in peripheral cells in Alzheimer’s disease, Parkinson’s disease, and Amyotrophic Lateral Sclerosis. Changes to the glycolytic pathway are seen early in neurodegenerative disease and highlight how in multiple neurodegenerative conditions pathology is not always confined to the nervous system. In this paper, we review the abnormalities described in glycolysis in the three most common neurodegenerative diseases. We show that in all three diseases glycolytic changes are seen in fibroblasts, and red blood cells, and that liver, kidney, muscle and white blood cells have abnormal glycolysis in certain diseases. We highlight there is potential for peripheral glycolysis to be developed into multiple types of disease biomarker, but large-scale bio sampling and deciphering how glycolysis is inherently altered in neurodegenerative disease in multiple patients’ needs to be accomplished first to meet this aim.
Tauopathies: Deciphering Disease Mechanisms to Develop Effective Therapies

Tauopathies are neurodegenerative diseases characterized by the pathological accumulation of microtubule-associated protein tau (MAPT) in the form of neurofibrillary tangles and paired helical filaments in neurons and glia, leading to brain cell death. These diseases include frontotemporal dementia (FTD) and Alzheimer’s disease (AD) and can be sporadic or inherited when caused by mutations in the MAPT gene. Despite an incredibly high socio-economic burden worldwide, there are still no effective disease-modifying therapies, and few tau-focused experimental drugs have reached clinical trials. One major hindrance for therapeutic development is the knowledge gap in molecular mechanisms of tau-mediated neuronal toxicity and death. For the promise of precision medicine for brain disorders to be fulfilled, it is necessary to integrate known genetic causes of disease, i.e., MAPT mutations, with an understanding of the dysregulated molecular pathways that constitute potential therapeutic targets. Here, the growing understanding of known and proposed mechanisms of disease etiology will be reviewed, together with promising experimental tau-directed therapeutics, such as recently developed tau degraders. Current challenges faced by the fields of tau research and drug discovery will also be addressed.
The Effects of Combined Infill Patterns on Mechanical Properties in FDM Process

Fused deposition modeling (FDM) is commonly used to print different products with highly complex features. Process parameters for FDM are divided into controllable or uncontrollable parameters. The most critical ones are built orientation, layer thickness, infill pattern, infill density, and nozzle diameter. This study investigates the effects of combined infill patterns in 3D printed products. Five patterns (solid, honeycomb, wiggle, grid, and rectilinear) were combined in samples to analyze their effects on mechanical properties for tensile strength analysis. Polylactic acid (PLA) samples were printed in different build orientations through two directions: flat and on-edge. The limitation was that the software and machine could not combine the infill patterns. Thus, the patterns were designed and assembled in computer aided design (CAD) software. Finite element analysis (FEA) was used to determine the patterns’ features and results showed honeycomb and grid have the highest strength while their weights were lighter compared to solid. Moreover, 0° samples in both flat and on-edge direction had the strongest layer adhesion and the best quality. In contrast, perpendicular samples like 60° and 75° showed poor adhesion and were the weakest specimens in both flat and on-edge, respectively. In brief, by increasing the build orientation, the strength decreases in this study.
Associations of Serum Lipid Level with Gastric Cancer Risk, Pathology, and Prognosis

Purpose The association of serum lipids with gastric cancer is controversial. We clarified the role of serum lipids in the development, progression, and prognosis of gastric cancer. Materials and Methods In total, 412 patients diagnosed with gastric cancer were prospectively recruited, and 2,934 control subjects who underwent screening endoscopy were enrolled from December 2013 to March 2017 to conduct a case-control study in a tertiary center. Serum lipid profiles, including total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglyceride (TG), apolipoprotein A-I (apoA-I), and apolipoprotein B, and clinicopathologic characteristics were analyzed. Results The gastric cancer group showed significantly lower HDL-C, higher LDL-C, and lower apoA-I level than the control group. In multivariate analysis, old age (odds ratio [OR], 1.051; p < 0.001), smoking (OR, 1.337; p < 0.001), a family history of gastric cancer (OR, 2.038; p < 0.001), Helicobacter pylori seropositivity (OR, 4.240; p < 0.001), lower HDL-C (OR, 0.712; p=0.020), and higher LDL-C (p=0.002) were significant risk factors for gastric cancer. Lower HDL-C and higher LDL-C remained significant after adjustments for covariates, including age and sex. In a subgroup analysis of the gastric cancer group, lower TG levels were associated with undifferentiated histology. No serum lipids were associated with overall survival. Conclusion Lower HDL-C and higher LDL-C were associated with the risk of gastric cancer, even after adjusting for age, sex, and other factors. In the gastric cancer group, undifferentiated histology was associated with lower TG levels.
mMotiv8: A smartphone-based contingency management intervention to promote smoking cessation.

Cigarette smoking is the leading preventable cause of death and illness in the United States. We tested the usability, acceptability, and efficacy of a smartphone-based contingency management treatment to promote cessation. We used a nonconcurrent multiple-baseline design. Participants (N = 14) provided breath carbon monoxide (CO) samples by using a CO meter that was connected to the user's smartphone. An app (mMotiv8) housed on participants' smartphones automatically captured pictures of the CO sampling procedure to validate the end user's identity, and it prompted submissions via a push message delivered to participants' smartphones. Participants earned a $10 incentive for daily abstinence, which was added to a reloadable debit card. Overall, 4% of the CO samples were negative during baseline, and 89% were negative during treatment. Self-reported usability and acceptability were high, and 85% of the prompted samples were submitted. A smartphone intervention could be scalable and reduce the health consequences and costs associated with cigarette smoking, particularly in rural and low-income populations.
Valuation of peers’ safe choices is associated with substance-naïveté in adolescents

Significance During adolescence, substance use and other health-risk behaviors emerge, particularly among those who associate with peers engaging in such behaviors and less so for adolescents with less deviant peers. Here, we provide behavioral and neural evidence for a beneficial role of safer peers, rather than a detrimental influence of risky peers, in guiding adolescents’ choices and substance use. The extent to which adolescents value peers’ safe choices predicted substance-naïveté even after controlling for other factors associated with substance use, while valuation of peers’ risky choices was unrelated to substance use. Whereas previous studies have largely examined associations between negative peers and increased health-risk behaviors, our data support a significant role of positive social peers for favorably influencing health-risk behaviors. Social influences on decision-making are particularly pronounced during adolescence and have both protective and detrimental effects. To evaluate how responsiveness to social signals may be linked to substance use in adolescents, we used functional neuroimaging and a gambling task in which adolescents who have and have not used substances (substance-exposed and substance-naïve, respectively) made choices alone and after observing peers’ decisions. Using quantitative model-based analyses, we identify behavioral and neural evidence that observing others’ safe choices increases the subjective value and selection of safe options for substance-naïve relative to substance-exposed adolescents. Moreover, the effects of observing others’ risky choices do not vary by substance exposure. These results provide neurobehavioral evidence for a role of positive peers (here, those who make safer choices) in guiding adolescent real-world risky decision-making.
I've seen enough! Prolonged and repeated exposure to disgusting stimuli increases oculomotor avoidance.

Disgust motivates avoidance of stimuli associated with pathogens. Although disgust primarily inhibits oral and epidermal contact, it may also inhibit perceptual contact, particularly given the outsize role of sensory qualities in eliciting disgust. To examine perceptual avoidance of disgust, we presented images of bodily products or spoiled food paired with neutral images for 12-s trials and recorded eye movements (Experiment 1; N = 127). We found that, overall, these disgusting images were not visually avoided compared to neutral images. However, viewing of disgusting images decreased with prolonged (within-trial) and repeated (between-trial) exposure, and these trends were predicted by self-reported disgust to the images. In Experiment 2 (N = 84), we replicated Experiment 1 with a novel set of disgusting images, as well as other unpleasant image categories (suicide, threat) and pleasant images. We found that disgusting stimuli were viewed less than the other unpleasant image categories, and we again found that viewing of disgusting images decreased with prolonged and repeated exposure. Further, we replicated the finding that disgust ratings predicted decreasing viewing of disgusting images, but only for prolonged exposure (within-trial). Unexpectedly, we found that disgust ratings predicted a similar pattern of decreasing viewing for the suicide and threat images as well. These findings suggest that disgust inhibits perceptual contact, but in competition with motivational processes that steer attention toward pathogen threats. We discuss the implications for measuring disgust with eye tracking. (PsycInfo Database Record (c) 2020 APA, all rights reserved).
Research Review: Developmental origins of depression – a systematic review and meta‐analysis

Background Many observational studies have found a direct association between adverse in utero, perinatal and postnatal exposures and offspring’s depression. These findings are consistent with the ‘developmental origins of disease hypothesis’. But no review has comprehensively summarized the roles of these exposures. This review aims to systematically scrutinize the strength of associations between individual prenatal, perinatal, and postnatal exposures and subsequent depression in offspring. Methods We conducted a systematic review and meta‐analysis to synthesize the literature from the EMBASE, HealthStar, PsychoInfo, and Medline databases since their inception to September 1, 2019. English language articles on population‐based prospective cohort studies examining the associations between in utero, perinatal, and postnatal exposures and offspring’s depression were searched. Random‐effects models were used to calculate pooled estimates, and heterogeneity and sensitivity tests were conducted to explore potential confounders in the relationships of depression and early‐life factors. Qualitative analysis was also conducted. Results Sixty‐four prospective cohort studies with 28 exposures studied in the relationships to offspring’s depression met inclusion criteria. The meta‐analysis found 12 prenatal, perinatal, and postnatal characteristics were associated with an increased risk of depression in offspring: low birth weight, premature birth, small gestational age, maternal education, socioeconomic status, having younger parents (<20 years), having older parents (≥35 years), maternal smoking, paternal smoking, maternal stress, maternal anxiety, and prenatal depression. Heterogeneity and sensitivity tests supported the findings. By and large, study characteristics had no effects on conclusions. Qualitative analyses generally supported the findings of meta‐analysis and reported on additional risk factors. Conclusions This review provides a robust and comprehensive overview of the lasting psychopathological effects of in utero, perinatal, and postnatal exposures. The findings highlight the need for clinical and public health interventions focusing on the identified risk factors. Large prospective cohort studies are warranted to investigate the combined effects of multiple co‐existing early‐life exposures.
The role of sensory uncertainty in simple contour integration

Perceptual organization is the process of grouping scene elements into whole entities. A classic example is contour integration, in which separate line segments are perceived as continuous contours. Uncertainty in such grouping arises from scene ambiguity and sensory noise. Some classic Gestalt principles of contour integration, and more broadly, of perceptual organization, have been re-framed in terms of Bayesian inference, whereby the observer computes the probability that the whole entity is present. Previous studies that proposed a Bayesian interpretation of perceptual organization, however, have ignored sensory uncertainty, despite the fact that accounting for the current level of perceptual uncertainty is one of the main signatures of Bayesian decision making. Crucially, trial-by-trial manipulation of sensory uncertainty is a key test to whether humans perform near-optimal Bayesian inference in contour integration, as opposed to using some manifestly non-Bayesian heuristic. We distinguish between these hypotheses in a simplified form of contour integration, namely judging whether two line segments separated by an occluder are collinear. We manipulate sensory uncertainty by varying retinal eccentricity. A Bayes-optimal observer would take the level of sensory uncertainty into account—in a very specific way—in deciding whether a measured offset between the line segments is due to non-collinearity or to sensory noise. We find that people deviate slightly but systematically from Bayesian optimality, while still performing “probabilistic computation” in the sense that they take into account sensory uncertainty via a heuristic rule. Our work contributes to an understanding of the role of sensory uncertainty in higher-order perception.
Demographic, personality, and social cognition correlates of coronavirus guideline adherence in a U.S. sample.

OBJECTIVE The present study examined patterns and psychosocial correlates of coronavirus guideline adherence in a U.S. sample (N = 500) during the initial 15-day period advocated by the White House Coronavirus Task Force. METHOD Descriptive and correlational analyses were used to examine the frequency of past 7-day adherence to each of 10 guidelines, as well as overall adherence. Guided by a disposition-belief-motivation model of health behavior, path analyses tested associations of personality traits and demographic factors to overall adherence via perceived norms, perceived control, attitudes, and self-efficacy related to guideline adherence, as well as perceived exposure risk and perceived health consequence if exposed. RESULTS Adherence ranged from 94.4% reporting always avoiding eating/drinking inside bars/restaurants/food courts to 13.6% reporting always avoiding touching one's face. Modeling showed total associations with overall adherence for greater conscientiousness (β = .191, p < .001), openness (β = .098, p < .05), perceptions of social endorsement (β = .202, p < .001), positive attitudes (β = .105, p < .05), self-efficacy (β = .234, p < .001), and the presence versus absence or uncertainty of a shelter-in-place order (β = .102, p < .01). Age, self-rated health, sex, education, income, children in the household, agreeableness, extraversion, neuroticism, perceived exposure risk, and perceived health consequence showed null-to-negligible associations with overall adherence. CONCLUSIONS The results clarify adherence frequency, highlight characteristics associated with greater adherence, and suggest the need to strengthen the social contract between government and citizenry by clearly communicating adherence benefits, costs, and timelines. (PsycInfo Database Record (c) 2020 APA, all rights reserved).