Miracle-dz/UniFAR-FTUs huggingface dataset:
Systematic approach to crane-related near-miss analysis in the construction industry

ABSTRACT The use of near-miss management systems in construction is relatively new and has not been fully explored or understood. Near misses have not been investigated in a systematic perspective that will enable an analysis from a given set of reported incidents. This research effort suggests a systematic approach to near-miss analysis and concentrates on tower-crane-related near-miss events due to the centrality of tower cranes in nowadays construction and their potential as hazard generators on construction sites. The study began with an extensive effort to collect stories of safety events, including near misses and accidents. An exploratory research method was then implemented in developing a comprehensive database of crane-related accidents and near-miss events. The database classifies each event using a set of encoded variables that disclose event definition, crane status, activity, main incident factor and more. The applicability of the database is demonstrated by providing support to the notion of cause commonality between accidents and near misses, an issue that has been studied in the context of other industries. Further investigation into the causal factors preventing near misses from developing into full-scale accidents provided an important insight on the benefit of near-miss investigations.
Macroporous Silicon for Gas Detection Macroporous Silicon for Gas Detection

Macroporous silicon (MPS) has been shown to be a promising material in many areas of technical interest. In particular, MPS has been applied for electronic devices and microfluidic applications. One of the most promising features of MPS is that it enables the development of optical applications using simple and cost-effective technology, compatible with MEMS fabrication processes and suitable for mass production. This chapter describes the application of MPS structures fabricated using electrochemical etching (EE) for the detection of gases of environmental concern in the wavelength range comprising 4 μ m to 15 μ m, such as CO 2 . Vertical-modulated MPS structures are reported, whose photonic bandgaps can be placed at different wavelengths depending on the application needs. These structures have been applied to the quantification of CO 2 , and these results are summarised here. Detection is performed by the direct measure of absorption, obtaining promising results with short optical paths.
This information is current as Pathogenic Effector T Cell Proliferation Mechanism Underlying Unrestrained Regulatory T Cells in Psoriasis: high CD25 + Dysfunctional Blood and Target Tissue CD4

The balance between regulatory and effector functions is important for maintaining efﬁcient immune responses, while avoiding autoimmunity. The inﬂammatory skin disease psoriasis is sustained by the ongoing activation of pathogenic effector T cells. We found that a CD4 (cid:1) T lymphocyte subpopulation in peripheral blood, phenotypically CD25 high , CTLA-4 (cid:1) , Foxp3 high (regulatory T (Treg) cells), is deﬁcient in its suppressor activity in psoriasis. This was associated with accelerated proliferation of CD4 (cid:1) responder T cells in psoriasis, the majority of which expressed CXCR3. Nevertheless, criss-cross experiments isolated the defect to psoriatic Treg cells. To examine Treg cells in a nonlymphoid tissue of a human T cell-mediated disease, Treg cells were also analyzed and isolated from the site of inﬂammation, psoriatic lesional skin. At the regulatory vs effector T cells ratios calculated to be present in skin, however, the psoriatic Treg cell population demonstrated decreased suppression of effector T cells. Thus, dysfunctional blood and target tissue CD4 (cid:1) CD25 high Treg cell activity may lead to reduced restraint and consequent hyperproliferation of psoriatic pathogenic T cells in vivo. These ﬁndings represent a critical component of human organ-speciﬁc autoimmune disease and may have important implications with regard to the possible therapeutic manipulation of Treg cells in vivo. The Journal of Immunology, 2005, 174: 164–173. Psoriatic lesional Treg cells exhibit deﬁcient inhibitory effects on Tresp cells
ANALYSIS OF SELECTED PAVEMENT SERVICEABILITY PARAMETERS ANALYSIS OF SELECTED PAVEMENT SERVICEABILITY PARAMETERS

particular road surface particular The coefficient of friction measure of defined the ratio of the load (the force applied in the vertical direction) the traction (the force resisting movement in the horizontal direction). Friction is by a large number of parameters relating to the road and the tyre but it is also affected by other influences that may not be directly attributable to them, as the vehicle suspension, ambient conditions, speed and the presence of localised contaminants (including water) The mechanisms of tyre/road friction not fully understood, widely there molecular adhesion and hysteresis losses, ideas by Kummer in a unified theory of tyre/road friction the a overall friction between tyre and road surface is the sum of these two com-ponents The parameters of pavement serviceability have the notable effect to the road life time and to the conditions of safe and comfortable driving. The serviceability of flexible pavements is defined by three parameters: skid resistance, unevenness and pavement distress. The Slovak Road Administration observes 24 specific road sections on which the parameters have been measured two times per year since 1998. The obtained data should be used for determination of the degradation models that describe the qualitative decreasing of the parameters depending on time and traffic load. The functions are very important for definition of the optimal road maintenance and rehabilitation. The degradation models describing the parameters changes over time are the substantial research problem in dependence on many affecting factors. The results of pavement serviceability parameters evaluation are presented in the paper. The basic functions are described and discussed.
Mediates the Cooperative Development of STAT6 Expression in Multiple Cell Types

Th2 cells induce asthma through the secretion of cytokines. Two such cytokines, IL-4 and IL-13, are critical mediators of many features of this disease. They both share a common receptor subunit, IL-4R a , and signal through the STAT6 pathway. STAT6 2 / 2 mice have impaired Th2 differentiation and reduced airway response to allergen. Transferred Th2 cells were not able to elicit eosinophilia in response to OVA in STAT6 2 / 2 mice. To clarify the role of STAT6 in allergic airway inﬂammation, we generated mouse bone marrow (BM) chimeras. We observed little to no eosinophilia in OVA-treated STAT6 2 / 2 mice even when STAT6 +/+ BM or Th2 cells were provided. However, when Th2 cells were transferred to STAT6 3 Rag2 2 / 2 mice, we observed an eosinophilic response to OVA. Nevertheless, the expression of STAT6 on either BM-derived cells or lung resident cells enhanced the severity of OVA-induced eosinophilia. Moreover, when both the BM donor and recipient lacked lymphocytes, transferred Th2 cells were sufﬁcient to induce the level of eosinophilia comparable with that of wild-type (WT) mice. The expression of STAT6 in BM-derived cells was more critical for the enhanced eosinophilic response. Furthermore, we found a signiﬁcantly higher number of CD4 + CD25 + Foxp3 + T cells (regulatory T cells [Tregs]) in PBS- and OVA-treated STAT6 2 / 2 mouse lungs compared with that in WT animals suggesting that STAT6 limits both naturally occurring and Ag-induced Tregs. Tregs obtained from either WT or STAT6 2 / 2 mice were equally efﬁcient suppressing CD4 + T cell proliferation in vitro. Taken our demonstrate STAT6-dependent -independent features of allergic inﬂammation, which may impact treatments targeting
The Phosphoinositide-Specific Phospholipase C Inhibitor U73122 (1-(6-((17 Spontaneously Forms Conjugates with Common Components of Cell Culture Medium

: Phosphoinositide-specific phospholipase C (PLC) is a key enzyme in the regulation of Ca 2 (cid:2) release from inositol 1,4,5-triphosphate-sensitive stores. U73122 (1-(6-((17 (cid:1) -3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione) has been exten-sively used as a pharmacological inhibitor of PLC to elucidate the importance of this enzyme family in signal transduction pathways. U73122 has an electrophilic maleimide group, which readily reacts with nucleophiles such as thiols and amines. In the current study the conjugation of U73122 to common components of cell culture medium, namely L -glutamine, glutathione, and bovine serum albumin (BSA), was demonstrated. The half-life of U73122 on incubation with phosphate-buffered saline (PBS), Hanks’ buffered saline solution (with 2 mM glutamine), optimized basal nutrient medium (MCDB131, without BSA), complete medium, Dulbecco’s modified Eagle’s medium (with 2 mM L -glutamine) was (cid:1) 150, 60, 32, 30, and 18 min, respectively. However, U73122 was not recoverable from medium supplemented with 0.5% BSA. U73122 underwent hydrolysis of the maleimide
(CANCER Inhibition by Parvo virus H-l of the Formation of Tumors in Nude Mice and Colonies in Vitro by Transformed Human Mammary Epithelial Cells'

The formation of tumors in adult nude mice from transformed human mammary epithelial cells was drastically inhibited (>80%) both after coinjection of tumoral cells and virus or after a single s.c. injection of parvovirus H-l at the site of cell implantation prior to tumor formation. Moreover, when injected i.v. in animals bearing preformed tumors, H-l virus was able to slow down and even in some cases to revert neoplastic growth. Thus, H-l virus achieved the suppression of implanted tumors of human origin under conditions where the immune antitumor mecha nisms of the recipient animals were dramatically impaired. Viral infection was not accompanied by detectable deleterious side effects. Imprints of H-l virus DNA were found in one residual tumor. Normal human mammary epithelial cells were also compared with homologous trans formed cells, either derived from tumors (three lines) or containing simian virus 40 (one line), for their susceptibility to the lytic replication of H-l virus in vitro. Transformed cell lines were more sensitive to virus-induced killing than secondary cultures of normal cells. Moreover, the former had much greater abilities than the latter to amplify viral DNA and to express the viral nonstructural protein NS-1. Altogether, these results are compatible with the idea that the oncosuppressive activity exerted by H-l virus may be mediated, at least in part, by virus replication in developing tumors.
University of Birmingham Attachment styles in children living in alternative care: a systematic review of the literature

Background A large number of children are currently living in Alternative Care. The relationship they establish with their temporary caregivers can play a signiﬁcant role in their development. However, little has been published regarding attachment with temporary Caregivers . Objective The aim of this review is to analyse the existing published studies regarding attachment styles in children living in alternative care (Children’s Homes and Foster Care). The review analyses rates of attachment styles and associated factors (including characteristics of settings, children and caregivers) in both settings. Methods A systematic literature review was conducted searching electronic databases for peer reviewed publications in different languages. Studies considering attachment in children living in Children’s Homes or Foster families at the time of the study were included. Overall, 18 articles reporting 13 studies met the inclusion criteria. The results are presented in terms of characteristics of the studies, rates of attachment in different settings and possible mediating factors. Implications for practice and research are discussed. Conclusions Attachment styles in children living in alternative care differ from those observed in children living with biological or adoptive families, however several factors can mediate this outcome (including characteristics of settings, children and caregivers). Most research has been conducted in Europe and USA. Therefore, further research is needed in less developed countries in order to guide local policies for better care.
and Dengue Viruses with NK Cells Envelope Glycoproteins from the West Nile NKp44 Receptor Mediates Interaction of the

Dengue virus (DV) and West Nile virus (WNV) have become a global concern due to their widespread distribution and their ability to cause a variety of human diseases. Antiviral immune defenses involve NK cells. In the present study, we investigated the interaction between NK cells and these two ﬂaviviruses. We show that the NK-activating receptor NKp44 is involved in virally mediated NK activation through direct interaction with the ﬂavivirus envelope protein. Recombinant NKp44 directly binds to puriﬁed DV and WNV envelope proteins and speciﬁcally to domain III of WNV envelope protein; it also binds to WNV virus-like particles. These WNV-virus-like particles and WNV-domain III of WNV envelope protein directly bind NK cells expressing high levels of NKp44. Functionally, interaction of NK cells with infective and inactivated WNV results in NKp44-mediated NK degranulation. Finally, WNV infection of cells results in increased binding of rNKp44 that is speciﬁcally inhibited by anti-WNV serum. WNV-infected target cells induce IFN- (cid:1) secretion and augmented lysis by NKp44-expressing primary NK cells that are blocked by anti-NKp44 Abs. Our ﬁndings show that triggering of NK cells by ﬂavivirus is mediated by interaction of NKp44 with the ﬂavivirus envelope protein. The Journal of Immunology, 2009, 183: 2610–2621. was preincubated with anti-ILT2 HP-F 1 mAb for 30 min; alternatively, target cells were incubated with W6/32 to block ligands for NK inhibitory receptors. For additional blocking with Abs, NK cells were preincubated on ice for 30 min with polyclonal mouse serum diluted 1/80 before being combined with target cells. In all experiments shown, the spontaneous release was (cid:6) 25% of maximal release. IFN- (cid:5) assays. Human IFN- (cid:5) concentrations in the supernatants of NK cells coincubated with target cells for 24 h were assayed by standard ELISA, according to the manufacturer’s instructions (BioLegend).
Mycorrhiza improves plant growth and photosynthetic characteristics of tea plants in response to drought stress

Tea plants are sensitive to soil moisture deficit, with the level of soil water being a critical factor affecting their growth and quality. Arbuscular mycorrhizal fungi (AMF) can improve water and nutrient absorption, but it is not clear whether AMF can improve the photosynthetic characteristics of tea plants. A potted study was conducted to determine the effects of Claroideoglomus etunicatum on plant growth, leaf water status, pigment content, gas exchange, and chlorophyll fluorescence parameters in Camellia sinensis cv. Fuding Dabaicha under well-watered (WW) and drought stress (DS) conditions. Root mycorrhizal colonization and soil hyphal length were significantly reduced by the eightweek DS treatment. AMF inoculation displayed a significant increase in shoot and root biomass production. The relative water content, leaf water potential, nitrogen balance index, pigment content, maximum photometric effect (Fv/Fm, QY_max), and steady-state photometric effect Y (II) (QY_Lss) decreased dramatically, while the leaf water saturation deficit and steady-state non-photochemical fluorescence quenching (NPQ_Lss) generally increased under DS conditions. Mycorrhizal treatment induced significantly higher relative water content, leaf water potential, nitrogen balance index, pigment (chlorophyll, flavonoid, and anthocyanin) content, net photosynthesis rate, transpiration rate, stomatal conductance, intercellular CO2 concentration, QY_max, and QY_Lss; however, it resulted in a lower leaf water saturation deficit and NPQ_Lss under both WW and DS conditions, as compared with nonmycorrhizal plants. These results imply that AMF promoted tea plant growth and alleviated negative effects of DS by promoting gas exchange, regulating the water status of leaves, and regulating photosynthetic parameters.
Epistemic Modalities

I present an analysis of the notion of epistemic modalities, based on an appropriate interpretation of two basic constructivist issues: veri(cid:28)cation and epistemic agency. Starting from an histori-cal analysis of conditions for judgments, I analyze (cid:28)rst the reading of necessity with respect to apodictic judgements, and then that of possibility with respect to hypothetical judgement. The analyis re-sults in a formal treatment of rules for judgemental modal operators, whose aim is to preserve epistemic states corresponding to veri(cid:28)ed and unveri(cid:28)ed assumptions in contexts. In the conclusion, further tracks of research are indicated for designing a semantic framework and de(cid:28)ning multi-agents systems.
Sensitization in Mice Secondhand Smoke Induces Allergic

Epidemiological studies have suggested increased prevalence of atopy in children of maternal smokers. Although secondhand smoke or environmental tobacco smoke (ETS) has been shown to augment allergic responses, its role in atopic sensitization is still controversial. We studied whether ETS could initiate a Th2 response and thus induce primary allergic sensitization. Mice were exposed for 10 consecutive days to either 1% aerosolized OVA, ETS (5 cigarettes), or both ETS and OVA. C57BL/6 mice receiving both ETS and OVA developed OVA-speciﬁc IgE and IgG1, 12, 14, and 25 days after the initial exposure, whereas those receiving OVA alone did not. Thirty days after the initial challenge (20 days after its completion), mice were re-exposed to OVA. Bronchoalveolar lavage performed 24 h later revealed an inﬂux of eosinophils in the group initially challenged with both ETS and OVA, but not in those exposed to ETS alone or OVA alone. Increases in IL-5, GM-CSF, and IL-2 were observed in bronchoalveolar lavage from this OVA/ETS-exposed group, whereas IFN- (cid:1) levels were signiﬁcantly inhibited. These results suggest that ETS can induce allergic sensitization to a normally harmless Ag, and they may explain why secondhand smoke is a major risk factor for the development of allergy in children. The Journal of Immunology, 2001, 167: 4765–4770.
A global marketing logic: local stakeholders ’ influence in diverse emerging markets

Purpose – Theauthorsdiscussadominantlogicasthemainideabehindaglobalmarketinglogic(GML)ofan MNE and investigate how local stakeholders ’ influence the feasibility of applying the GML in emerging markets. The aim of the paper is to enhance the understanding of the factors that influence the local stakeholders ’ acceptance of the MNEs ’ GML and the different activities of MNEs that may increase the acceptance. Design/methodology/approach – The authors apply a qualitative case study method investigating three SwedishMNEsandtheiractivitieswhileimplementingaGMLinthebigemergingmarkets.Theauthorsstudytheirrelationshipswithbusiness,politicalandsocialstakeholders. Findings – The authors identify three persistent contents of the GML: (1) a consistent value chain role across markets, (2) standardized, premium products/services and promotion strategies, (3) a corporate brand-based identity. Thedevelopment oftrust, commitment,legitimacyandpower withinlocal stakeholders ’ relationships influences the approval. The acceptance of the MNE ’ s GML by local stakeholders strengthens its market position. Originality/value – The authors extend the knowledge by investigating the nature of a GML and explain to what extent it may help MNEs to gain a competitive position. The authors also discuss how global and local activitiesmayinfluencelocalstakeholders ’ acceptance.Thisstudycontributestowardsabetterunderstanding of how and to what extent a GML can be successful.
OPTH_A_307020 2133..2140

1Department of Ophthalmology, La Paloma Hospital, Las Palmas de Gran Canaria, Canary Islands, Spain; 2Department of Ophthalmology, PérezSilguero Ophthalmologic Clinic, Las Palmas de Gran Canaria, Canary Islands, Spain; 3Department of Health Technology Assessment, Fundación Canaria Instituto de Investigación Sanitaria de Canarias (FIISC), Las Palmas de Gran Canaria, Canary Islands, Spain; 4Department of Community and Family Medicine, Primary Care Center of Cuevas Torres, Las Palmas de Gran Canaria, Canary Islands, Spain Purpose: To assess the effectiveness of a combination of intense pulsed light and low-level light therapy (IPL/LLLT) for the treatment of dry eye. Study Design: Retrospective before-after single-center clinical study. Materials and Methods: Patients diagnosed with dry eye, refractory to conventional treatment, underwent four sessions of combined IPL/LLLT over 3 months. The Ocular Surface Disease Index (OSDI) questionnaire, non-invasive breakup time (NIBUT), tear film osmolarity and meniscus height were measured 6 months before intervention, at baseline, post-intervention (3 months), 9 and 15 months. Results: NIBUT, osmolarity and meniscus height significantly worsened during the 6 months before treatment, whereas symptoms did not change. OSDI scores significantly improved at post-intervention (MD = −44.0, 95% CI −38.1, −50.0), and then increased again until the at last follow-up, but still significantly different from baseline (MD = −30.0, 95% CI −23.4, −36.8). The three clinical signs showed a similar pattern, with one-year improvements of 3.6 seconds for the NIBUT (95% CI 3.1, 4.2, p <0.001), 28 mOsm/L for osmolarity (95% CI 23.6, 32.4, p <0.001) and 0.03 mm for meniscus height (95% CI 0.02, 0.04, p <0.001). No adverse effects were observed. Conclusion: IPL/LLLT is safe and produces an important reduction in symptoms and signs of dry eye disease, still relevant one year after the end of treatment in a sample with high symptoms’ severity. Therefore, it represents a promising treatment option for patients who do not improve with conventional treatment. Randomized trials are needed to determine the added benefit provided by LLLT.
Cooperative target-capturing with inaccurate target information

This paper presents distributed formation control of a multi-agent system to encircle a maneuvering target using Lyapunov and graph theories with emphasis on consensus and cooperation. The proposed approach embeds a consensus algorithm into a robust controller to capture a target whose information is partially known. To address this issue, a cooperative strategy in conjunction with a controller is proposed to enable a fleet of UAVs either to escort a target to a desired destination or to keep the target movement restricted in a certain set in order to gain superiority. We have employed a sliding mode controller to achieve a target centered formation whose information is partially available to the capturing vehicles. Simulation results are presented to validate the proposed approach.