Miracle-dz/UniFAR-FTUs huggingface dataset:
Nomogram Predicting Overall Survival in Patients with FIGO II to III Squamous Cell Cervical Carcinoma Under Radical Radiotherapy: A Retrospective Analysis Based on 2018 FIGO Staging

Purpose To present a nomogram to predict overall survival in patients with FIGO-2018 II to III squamous cell cervical carcinoma undergoing radical radiotherapy. Patients and Methods Patients diagnosed with FIGO-2018 II to III squamous cell cervical cancer between December 2013 and December 2014 were analyzed retrospectively. The optimal cutoff point for tumor length and width were determined by R package. We identified prognostic factors by univariate and multivariate Cox proportional-hazard regression, then built a nomogram to visualize the prediction model. Our model was compared to the 2018 FIGO staging prediction model. Harrell’s concordance index, receiver operating characteristic curve, calibration plot were used to evaluate the discriminability and accuracy of the predictive models, and decision curve analysis (DCA) was used to show the net benefits. Results Data from 469 patients were included in the final analyses. The cutoff values of tumor length and width were 5.10 cm and 4.13 cm, respectively. Four independent prognostic variables—tumor length, tumor width, lower one-third vaginal involvement, and lymph node metastases—were used to establish the nomogram. The C-index of the nomogram was 0.71 (95%, CI = 0.66–0.77), which was better than that of the 2018 FIGO stage prediction model (C-index: 0.62, 95% CI = 0.58–0.66, p = 0.009). The calibration plot of the nomogram was a good fit for both 3-year and 5-year overall survival predictions. And DCA curves showed that net benefits for our model were higher than FIGO-2018 staging system. Conclusion A clinically useful nomogram for calculating overall survival probability in FIGO-2018 II to III squamous cell cervical cancer patients who had received radical radiotherapy was developed. Tumor length, tumor width, lower one-third vaginal involvement, and lymph node metastases were found to be independent prognostic factors. Our model performed better than the 2018 FIGO staging model. The findings could help clinicians in China to predict the survival of these patients in clinical care and research.
Prevalence of and Factors Associated with Diabetic Retinopathy in Patients with Diabetes Mellitus at Siriraj Hospital – Thailand’s Largest National Tertiary Referral Center

Purpose We aimed to determine the prevalence of and factors associated with diabetic retinopathy (DR) in patients with diabetes mellitus (DM) and to evaluate the relationship between significant factors and severity of DR. Patients and Methods A retrospective cross-sectional study of 1130 diabetic patients (mean age: 60 years, 62.7% female, 91% type 2 diabetes) was conducted in the diabetes clinic of Siriraj Hospital (Bangkok, Thailand) during January 2012 to June 2015. DR was graded as absent, mild, moderate, or severe non-proliferative DR, or proliferative DR. Multivariate logistic regression analysis was used to identify independent risk factors for DR in DM patients. Results The overall prevalence of DR was 34.78%. Multivariate analysis revealed duration of diabetes, glycated hemoglobin level (HbA1c), presence of albuminuria, and abnormal protective sensation to be independent risk factors for DR. The prevalence of DR increased with longer duration of diabetes (p < 0.001), deterioration of glucose control (p = 0.006 for HbA1c), presence of significant albuminuria (p = 0.010), and loss of protective sensation (p = 0.001). Conclusion In this study, one-third of DM were found to have DR. The independent predictors of DR were duration of diabetes, HbA1c level, presence of significant albuminuria, and impaired protective sensation. Heightened awareness of these risk factors will decrease the prevalence and severity of DR, and will improve early diagnosis and treatment of DR.
Comparing the efficiency of applying yeast of different generations in high gravity brewing

When fermenting beer, in addition to the formation of basic, secondary, and by-products, which largely determine the taste and aroma of the beverage, yeast is accumulated. Such yeasts can be reused in subsequent serial repitching, which allows cost savings compared to yeast cultivated for each fermentation. This paper investigates the influence of yeast generation on the progress of the wort fermentation process and the quality of beer obtained, specifically in high gravity brewing. It was established that the increase in the number of yeast generation in the range from the first to the fourth generation causes a slight acceleration of the fermentation process of high-gravity wort, while at higher values of the fermentation generation number it slows down. Yeasts secreted after six or four serial wort fermentations with a gravity of 15 °P/18 °P, respectively, have a good physiological state and can be reused. The yeast generation number does not significantly affect ethanol content and sensory beer quality indicators. However, the use of yeast of the seventh and eighth generation causes a slight increase in the pH and color of high gravity beer, the appearance in the aroma of noticeable extraneous shades ‒ yeast tone, tone of young beer. As wort gravity increases, the number of yeast re-use cycles decreases, which is a consequence of the influence of various stress factors, specifically high osmotic pressure, and increased ethanol levels. Therefore, for the fermentation of wort with a gravity of 15 °P, it is recommended to use yeast up to five generations, for 18 °P wort ‒ to four generations. To obtain beer with appropriate physicochemical parameters and high sensory evaluation in high gravity brewing technology, it is advisable to ferment wort with a gravity of 15 °P with yeast for up to five generations.
Removal of Diverse and Abundant ARGs by MF-NF Process from Pig Manure and Digestate

Antimicrobial resistances are emerging as one main threat to worldwide human health and are expected to kill 10 million people by 2050. Intensive livestock husbandry, along with biogas digestate, are considered as one of the biggest ARG reservoirs. Despite major concerns, little information is available on the diversity and abundance of various ARGs in small to large scale pig farms and biogas digestate slurry in Germany, followed by their consequent removal using microfiltration (MF)–nanofiltration (NF) process. Here, we report the identification and quantification of 189 ARGs in raw manure and digestate samples, out of which 66 ARGs were shared among manures and 53 ARGs were shared among both manure and digestate samples. The highest reported total ARG copy numbers in a single manure sampling site was 1.15 × 108 copies/100 µL. In addition, we found the absolute concentrations of 37 ARGs were above 105 copies/100 μL. Filtration results showed that the highly concentrated ARGs (except aminoglycoside resistance ARGs) in feed presented high log retention value (LRV) from 3 to as high as 5 after the MF-NF process. Additionally, LRV below 2 was noticed where the initial absolute ARG concentrations were ≤103 copies/100 μL. Therefore, ARG removal was found to be directly proportional to its initial concentration in the raw manure and in digestate samples. Consequently, some ARGs (tetH, strB) can still be found within the permeate of NF with up to 104 copies/100 μL.
EFFORTS TO OVERCOME CRIMINAL ACTS OF SKIMMING COMMITTED THROUGH ATMS IN THE PERSPECTIVE OF LAW NUMBER 19 OF 2016 CONCERNING EIT

Cybercrime is one form of the negative impact of the development of science and technology. One of the crimes in the form of Cybercrime, which in recent years has greatly disturbed the public, is skimming. Skimming crimes continue to increase and are unsettling the community. For this reason, serious efforts to overcome them are required. This study aims to examine the effort to overcome criminal acts of skimming committed through ATMs in the Perspective of Law Number 19 of 2016 concerning EIT. This study is legal research with a literature study. The research approaches used are the statute approach and the fact-based approach. The results of this study revealed that as an effort to tackle skimming crime, there are two ways that can be applied, namely preventive action (preventing crime from occurring) and repressive action (efforts taken after a crime has occurred). The repressive measures that can be taken in tackling the crime of skimming are to apply legal provisions in accordance with Article 30 in conjunction with Article 46 of Law Number 19 of 2016 concerning Amendments to Law Number 11 of 2008 concerning EIT.
Role of parents, teachers at home and school in prevention of female sexual abuse: an analysis

Background: Sexual assault is an act performed by one person on another without the person’s consent or on a victim who is incapable of giving consent. The purpose of this article is to analyze the female sexual assault cases reported in one year –and the role of parents, teachers, at home and school in prevention of child sexual abuse.Methods: Data of victims who were admitted in GDMCH in the department of obstetrics and gynaecology in the year 2020 were collected from the medico legal register retrospectively and analyzed.Results: Age wise distribution showed 70% of cases were in the age group 15-19 years. 57% of assaults were with consent and 43% without consent. 93% of the perpetrators were known to the victim. Around 48% of the assaults were multiple episodes by a single perpetrator. The place of assault in 39% of cases was perpetrator’s house, 35% was in friend’s or relative’s house.Conclusions: 86% of the victims were <19 years of age, hence, educational awareness services are to be given to high school students and teachers . School authorities and teachers should implement strict vigilance against improper use of the internet and mobile phones by the students. Most common location of assault was the perpetrator's house (39%), followed by their friend’s house (22%). Hence parents should take every care to watch over the child and never leave them unsupervised.
Compromised fractalkine signaling delays microglial occupancy of emerging modules in the multisensory midbrain

Microglial cells (MGCs) are highly dynamic and have been implicated in shaping discrete neural maps in several unimodal systems. MGCs respond to numerous cues in their microenvironment, including the neuronally expressed chemokine, fractalkine (CX3CL1), via interactions with its corresponding fractalkine receptor (CX3CR1). The present study examines microglial and CX3CL1 patterns with regard to the emerging modular‐extramodular matrix organization within the lateral cortex of the inferior colliculus (LCIC). The LCIC is a multisensory shell region of the midbrain inferior colliculus where discrete compartments receive modality‐specific connections. Somatosensory inputs terminate within modular confines, while auditory inputs target the surrounding matrix. Glutamic acid decarboxylase (GAD) is an established marker of LCIC modules in developing mouse. During early postnatal development, multimodal LCIC afferents segregate into discrete, neurochemically defined compartments. Here, we analyzed neonatal GAD67‐GFP (GFP is defined as green fluorescent protein) and CX3CR1‐GFP mice to assess: (1) whether MGCs are recruited to distinct LCIC compartments known to be undergoing active circuit assembly, and (2) if such behaviors are fractalkine signaling‐dependent. MGCs colonize the nascent LCIC by birth and increase in density until postnatal day 12 (P12). At the peak critical period (P4‐P8), MGCs conspicuously border emerging LCIC modules, prior to their subsequent invasion by P12. CX3CL1 expression becomes distinctly modular at P12, in keeping with the notion of fractalkine‐mediated recruitment of microglia to modular centers. In CX3CR1GFP/GFP mice with compromised fractalkine signaling, microglial recruitment into modules is delayed. Taken together, these results suggest a potential role for microglia and fractalkine signaling in sculpting multisensory LCIC maps during an early critical period.
Prevalence and Antimicrobial Resistance of Paeniclostridium sordellii in Hospital Settings

(1) Background: The purpose of this study was to determine the prevalence of clostridia strains in a hospital environment in Algeria and to evaluate their antimicrobial susceptibility to antibiotics and biocides. (2) Methods: Five hundred surface samples were collected from surfaces in the intensive care unit and surgical wards in the University Hospital of Tlemcen, Algeria. Bacterial identification was carried out using MALDI-TOF-MS, and then the minimum inhibitory concentrations (MICs) of various antimicrobial agents were determined by the E-test method. P. sordellii toxins were searched by enzymatic and PCR assays. Seven products intended for daily disinfection in the hospitals were tested against Clostridium spp. spore collections. (3) Results: Among 100 isolates, 90 P. sordellii were identified, and all strains were devoid of lethal and hemorrhagic toxin genes. Beta-lactam, linezolid, vancomycin, tigecycline, rifampicin, and chloramphenicol all proved effective against isolated strains. Among all strains tested, the spores of P. sordellii exhibited remarkable resistance to the tested biocides compared to other Clostridium species. The (chlorine-based 0.6%, 30 min), (glutaraldehyde solution 2.5%, 30 min), and (hydrogen peroxide/peracetic acid 3%, 15 min) products achieved the required reduction in spores. (4) Conclusions: Our hospital’s current cleaning and disinfection methods need to be optimized to effectively remove spores from caregivers’ hands, equipment, and surfaces.
Exercise training patterns and anthropometric characteristics of amateur motorcycle road racers

Exercise is an important component in preparing for competition. Failure to properly train can lead to performance decrements, fatigue and injury. Scientific based sport conditioning programs are available for a variety of sports. However, there is lack of information concerning sport conditioning for motorcycle road racing. The purpose of this investigation was to conduct an initial study of body mass index (BMI), estimated cardiorespiratory fitness (VO2max) and exercise training patterns of expert and novice amateur motorcycle road racers. A total of 53 Western Eastern Roadracing Association (WERA) racers provided self-reported height, weight, age, gender, resting heart rate (RHR), physical activity habits, aerobic exercise training patterns and resistance exercise training patterns on an on-line survey. Height and weight was used to calculate BMI. Gender, age, RHR and habitual physical activity were used to estimate VO2max. The Global Physical Activity Questionnaire was employed to assess total physical activity (PA) in minutes per week. A supplemental survey was utilized to assess exercise training participation, frequency, duration, resistance exercise selection, repetitions and sets. An independent sample t-test was used to compare BMI and estimated VO2max between expert and novice racers. A Mann-Whitney u test was performed to compare Total PA. Pearson Chi-Squared tests were used to compare exercise training patterns.Expert racers had a significantly lower mean BMI (p<.05) compared to novice racers, 23.55 and 25.77, respectively . No significant difference was found in estimated VO2max between expert and novices racers, 46.65 ml/kg/min and 44.31 ml/kg/min, respectively. A significant difference (p<.05) was found in Total PA. Expert racers had a mean total PA of 1110 min/wk and novice racers had a mean total PA of 743 min/wk. A significant difference (p< .05) was established in one resistance exercise (i.e. lunges). Novices had a larger participation rate compared to expert racers in the lunge resistance exercise.The findings do not provide sufficient information to conclusively develop a sport-specific exercise program. However, this study provides preliminary data concerning anthropometric and fitness characteristics of motorcycle road racers. Additional research is necessary to fully understand characteristics associated with improved motorcycle road racing performance.
Special Issue - Connectivism: Design and Delivery of Social Networked Learning Editorial

New technologies that influence how information is created and shared and how people connect and socialize hold promise for adoption in education. Much like the idea of a book necessitated the development of the library or the idea of structured curriculum and domains of knowledge produced classrooms, the idea of the Internet – distributed, social, networked – influences the structure of education, teaching, and learning. Educators and researchers face a challenge in determining how the existing education system will be influenced and the new roles that will be expected of learners, teachers, and administrators. Information-centric fields such as journalism have struggled with the new democracy of information creation for over a decade. The music industry continues to grapple with access issues and the “unbundling of the album” initiated by Napster and firmly entrenched by iTunes. Telephone companies face an uncertain future as Skype, Google Voice, and other web-based communication services increase in popularity. Essentially, the Internet has remade how society creates and shares content and how people communicate and interact. The implications for education are significant. Educators have explored the role of the Internet as a research and learning tool for several decades. In the late 1990s, social network services (e.g., Friendster) and easy publishing tools (such as blogs) increased the ability for anyone with an Internet connection to both publish and engage in online conversations. Since that time, we’ve experienced a decade of amazing innovation in social networking sites (Facebook, Twitter), in openness movements (open source, open access), in mobile technologies (mobile phones, iPads), in the growth of broadband, in gaming, in multimedia (YouTube, podcasts), and in new tools that blend the physical and virtual worlds (location-based services such as Foursquare and Groupon, augmented reality, “internet of things”). International Review of Research in Open and Distance Learning
An Empirical Investigation of Authorial Writing Styles Based on a Vietnamese Corpus

A growing body of evidence suggests groups of people have their unique writing style, e.g., language use of females-males, the elderly-the youth, and so on. However, previous studies of Vietnamese texts have not dealt with language use associated with authors’ occupation. This study aims to portray the different ways in which technical and non-technical groups of authors use personal pronouns and negative words based on VVC_JSEAL, a ten-thousandword Vietnamese news corpus. A combined qualitative and quantitative methodological approach was used to investigate authorial writing styles, including correspondence analysis along with sociolinguistic interpretation. Analysis of word use for occupational groups of authors revealed the most significant associations on writing style which were identified for either first or third personal pronouns. However, negative words demonstrate their insignificant associations, while a combination of these words and personal pronouns has more significant relationships with authorial writing style. This study implies that occupational group of authors has a unique linguistic style, and word-level features of that style will recur with a relative stable frequency.
STATIC! The Aesthetics of Energy in Everyday Things

Abstract: Static! is a project investigating interaction and product design as a way of increasing our awareness of how energy is used in everyday life. Revisiting the design of everyday things with focus on issues related to energy use, we have developed a palette of design examples in the form of prototypes, conceptual design proposals and use scenarios, to be used as a basis for communication and discussion with users and designers. With respect to design research and practice, the aim has been to develop a more profound understanding of energy as material in design, including its expressive and aesthetic potential, thus locating issues related to energy use at the centre of the design process.
Sociodemographic Determinants, Health Conditions, and Mental Status as Predictors of the Functional Status of Older Saudi People

The increasing population of Saudi elderly demands adequate assessment of their functional health status and mental status to improve their health and quality of life. This study aimed to determine the functional status of older Saudi people in performing basic activities of daily living (ADLs) and instrumental activities of daily living (IADLs) and its influencing factors. This quantitative, descriptive-correlational study surveyed a total of 203 participants using the Mini-Mental State Examination, Katz Index of ADL, and Lawton IADL. Overall, the participants had moderate cognitive impairment and were able to perform basic ADLs and IADLs independently, but they needed assistance in doing housework. Functional status was sensitive to their sociodemographic characteristics, presence of health problems, and mental status. Mental status, education, employment, marital status, and source of support were significantly associated with their ability to perform basic ADLs and IADLs. This study suggests that more efforts are needed to understand the sociodemographic characteristics, presence of health problems, and mental status that support the development of evidence-based public health policy on the functional status among older Saudi people. The findings can be utilized by hospital and nursing administrators to initiate educational and training programs for healthcare professionals including nurses and to create healthcare policies so that the health concerns and functional difficulties of older patients are adequately addressed.
S-palmitoylation and sterol interactions mediate antiviral specificity of IFITM isoforms

Interferon-induced transmembrane proteins (IFITM1, 2 and 3) are important antiviral proteins that are active against many viruses, including influenza A virus (IAV), dengue virus (DENV), Ebola virus (EBOV), Zika virus (ZIKV) and severe acute respiratory syndrome coronavirus (SARS-CoV). IFITMs exhibit isoform-specific activity, but their distinct mechanisms of action and regulation are unclear. Since S-palmitoylation and cholesterol homeostasis are crucial for viral infections, we investigated IFITM interactions with cholesterol by molecular dynamic stimulations, nuclear magnetic resonance analysis in vitro and photoaffinity crosslinking in mammalian cells. These studies suggest that cholesterol can alter the conformation of IFITMs in membrane bilayers and directly interact with S-palmitoylated IFITMs in cells. Notably, we discovered that the S-palmitoylation levels regulate differential IFITM isoform interactions with cholesterol in mammalian cells and specificity of antiviral activity towards IAV, SARS-CoV-2 and EBOV. Our studies suggest that modulation of IFITM S-palmitoylation levels and cholesterol interaction may influence host susceptibility to different viruses.