Miracle-dz/UniFAR-FTUs huggingface dataset:
Why is African Trade so Limited?

This paper studies the determinants of the low participation of African countries to international trade. We point out the under-trading status of Africa, then we estimate a gravity equation in order to identify the determinants of trade in general. As we characterize the level of these explanatory variables in Africa as compared to the rest of the world, we identify the main variables behind the low participation of Africa to trade in general. Usual gravity factors play an important role, but we show that non-tariff measures and the quality of infrastructure and institutions are important. Import duties does not significantly impede African exports. We test the impact on African countries’ exports of a counterfactual scenario where infrastructure and institution variables in African countries are changed to the world average and conclude that the most important leverage effect to be expected from investment in infrastructure would be from mobile cellular telephone subscriptions. If we consider only countries where exports are positively affected, this counterfactual exercise implies a change by 31.0% of national exports on average by African country. While this result is interesting it has to be considered with caution since the exact form of the relation between trade and mobile cellular telephone subscriptions is largely unknown.
Association of Lesion Location and Fatigue Symptoms After Ischemic Stroke: A VLSM Study

Background: Poststroke fatigue (PSF) is a common symptom in stroke survivors, yet its anatomical mechanism is unclear. Our study was aimed to identify which brain lesions are related to the PSF in patients with acute stroke. Method Patients with first-ever acute ischemic stroke consecutively admitted from the first affiliated hospital of the University of Science and Technology of China (USTC) between January 2017 and June 2020. Fatigue was scored using the Fatigue Severity Scale. All the participants were assessed by 3.0 T brain MRI including diffusion-weighted imaging. The infarct lesions were delineated manually and transformed into a standard template. Voxel-based lesion-symptom mapping (VLSM) was applied to investigate the association between lesion location and the occurrence and severity of fatigue. The same analyses were carried out by flipping the left-sided lesions. Multivariate logistic regressions were applied to verify the associations. Results Of the 361 patients with acute stroke, 142 (39.3%) patients were diagnosed with fatigue in the acute phase and 116 (35.8%) at 6 months after the index stroke. VLSM analysis indicated clusters in the right thalamus which was significantly associated with the occurrence and severity of PSF at 6-month follow-up. In contrast, no significant cluster was found in the acute phase of stroke. The flipped analysis did not alter the results. Multivariate logistic regression verified that lesion load in the right thalamus (OR 2.67, 95% CI 1.46–4.88) was an independent predictor of 6-month PSF. Conclusion Our findings indicated that lesions in the right thalamus increased the risk of fatigue symptoms 6 months poststroke.
Lifetime Dual Disorder Screening and Treatment Retention: A Pilot Cohort Study

The coexistence of a substance use disorder and another mental disorder in the same individual has been called dual disorder or dual diagnosis. This study aimed to examine the prevalence of lifetime dual disorder in individuals with alcohol or cocaine use disorder and their retention in treatment. We conducted a pilot cohort study of individuals (n = 1356) with alcohol or cocaine use disorder admitted to treatment in the public outpatient services of Barcelona (Spain) from January 2015 to August 2017 (followed-up until February 2018). Descriptive statistics, Kaplan–Meier survival curves and a multivariable Cox regression model were estimated. The lifetime prevalence of screening positive for dual disorder was 74%. At 1 year of follow-up, >75% of the cohort remained in treatment. On multivariable analysis, the factors associated with treatment dropout were a positive screening for lifetime dual disorder (HR = 1.26; 95% CI = 1.00–1.60), alcohol use (HR = 1.35; 95% CI = 1.04–1.77), polysubstance use (alcohol or cocaine and cannabis use) (HR = 1.60; 95% CI = 1.03–2.49) and living alone (HR = 1.34; 95% CI = 1.04–1.72). Lifetime dual disorder is a prevalent issue among individuals with alcohol or cocaine use disorders and could influence their dropout from treatment in public outpatient drug dependence care centres, along with alcohol use, polysubstance use and social conditions, such as living alone. We need a large-scale study with prolonged follow-up to confirm these preliminary results.
Cost-Effectiveness of Nivolumab Immunotherapy vs. Paclitaxel or Docetaxel Chemotherapy as Second-Line Therapy in Advanced Esophageal Squamous Cell Carcinoma in China

This study aimed to evaluate and compare nivolumab's cost-effectiveness with chemotherapy in patients with advanced esophageal squamous cell carcinoma from the Chinese healthcare system perspective. To this end, the researchers utilized a partitioned survival model with three mutually exclusive health stages. The characteristics of the patients used as inclusion and exclusion criteria in this model were the same as those used for patients with advanced esophageal squamous cell carcinoma in the ATTRACTION-3 study. The ATTRACTION-3 trial, which took place between January 7, 2016 and November 12, 2018, also yielded important clinical data. Data on medical and economic preferences were collected from real-world clinical practices. Costs, quality-adjusted life years, and incremental cost-effectiveness ratio were calculated for the two therapy options. The model uncertainty was investigated using a deterministic and probabilistic sensitivity analysis. When compared to chemotherapy, nivolumab was linked with an increase of 0.28 quality-adjusted life years with an increased cost of US$ 36,956.81 per patient in the base case analysis of a hypothetical sample of 419 patients. The incremental cost-effectiveness ratio in the deterministic sensitivity analysis was US$ 132,029.46/quality-adjusted life year, with a 48.02% probability of being cost-effective at willingness-to-pay thresholds of US$ 132,029.22/quality-adjusted life year. The incremental cost-effectiveness ratio remained greater than US$ 80,000/quality-adjusted life year in the deterministic sensitivity analyses. To be more cost-effective and remain below the threshold of 37,653 US$/quality-adjusted life year, which the Chinese population can afford, nivolumab's price would have to be lowered sharply by 53.50%. Nivolumab is clinically beneficial but not cost-effective when compared to chemotherapy. A substantial reduction in nivolumab's drug acquisition cost would be necessary to make it cost-effective for immunotherapy.
GnRH Antagonist Protocol Versus GnRH Agonist Long Protocol: A Retrospective Cohort Study on Clinical Outcomes and Maternal-Neonatal Safety

Objective To evaluate the clinical outcomes and maternal-neonatal safety of gonadotropin releasing hormone antagonist (GnRH-ant) and gonadotropin releasing hormone agonist (GnRH-a) protocols. Methods A total of 2505 women undergoing their first in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) were retrospectively analyzed. Patients were divided into GnRH-ant group (n = 1514) and GnRH-a group (n = 991) according their stimulation protocol. Propensity Score Matching (PSM) was used for balancing the baseline of two groups. The pregnancy outcomes were analyzed in fresh transfer cycles, and the obstetric and perinatal outcomes were calculated in singleton live births of fresh cycles. The primary outcome was the live birth rate. The secondary outcome measures were maternal complications, preterm birth rate, low birthweight rate, multiple pregnancy rate, and moderate-severe OHSS rate. Results After 1:1 PSM, baseline characteristics of the GnRH-ant group and GnRH-a group were matched and assigned 991 cycles in each group. Before PSM, there were 700 fresh cycles including 237 singleton live births in the GnRH-ant group and 588 fresh cycles including 187 singleton live births in the GnRH-a group. After PSM, there were 471 fresh cycles including 166 singleton live births in the GnRH-ant group and 588 fresh cycles including 187 singleton live births in the GnRH-a group. No significant differences were observed in the live birth rate (44.6% vs 48.8%), maternal complications, preterm birth rate (9.0% vs 6.4%), and low birthweight rate (17.5% vs 24.1%) between two groups after PSM (P > 0.05). The moderate-severe OHSS rate (2.9% vs 6.0%, P = 0.002) and multiple pregnancy rate (24.5% vs 33.1%, P = 0.025) was significantly lower in the GnRH-ant group than that in the GnRH-a group after PSM. Conclusion GnRH-ant protocol was comparable with GnRH-a protocol in clinical outcomes, obstetric and perinatal outcomes, and with a lower risk of OHSS. For those who want to get an effective and safe outcome, and a shorter treatment period, GnRH-ant is a suitable choice.
Investigations of Thermal Effects on Retrofitted Bosphorus Bridge: Comparison between Diagonal and Vertical Hanger Configurations

Bosphorus Bridge which was constructed in 1973 recently has undergone a retrofitting process. In the process, original diagonal hanger configuration has changed into the vertical configuration. Literature includes numerous studies which address almost every aspect of the structural analysis of the diagonal case but lacks any study concerning the recent vertical configuration. In this study, an advanced 3D finite element model (FEM) of the complete bridge has been developed with intricate details. The model includes detailed structural components such as stiffeners with realistic 3D towers and also incorporates a frictional contact model for the cable saddle interaction – a unique feature among the model realm. Both diagonal and vertical configurations are taken into consideration with an automated script in the framework of a commercial FEM package. In order to demonstrate the effectiveness and usefulness of the model, we have opted to work on thermal effects on the bridge among various other possible research directions which can be tractable by the model such as vehicle interactions, forced vibrations, fatigue etc. We have studied the effects of homogeneous heating of the deck structure and various parts of the towers for both configurations. Variations on the stress distributions of the deck structure and cable forces are investigated. It is seen that diagonal configuration is more sensitive to the thermal effects and thus the related fatigue.
ANGPTL3 Is Involved in the Post-prandial Response in Triglyceride-Rich Lipoproteins and HDL Components in Patients With Coronary Artery Disease

It is well-established that there exists an inverse relationship between high-density lipoprotein (HDL) cholesterol and triglyceride (TG) levels in the plasma. However, information is lacking on the impact of post-prandial triglyceride-rich lipoproteins (TRLs) on the structure of HDL subclasses in patients with coronary artery disease (CAD). In this study, the data of 49 patients with CAD were analyzed to evaluate dynamic alterations in post-prandial lipid profiles using nuclear magnetic resonance-based methods. An enzyme-linked immunosorbent assay was used to quantify the serum angiopoietin-like protein 3 (ANGPTL3). After glucose supplementation, the expression of hepatic ANGPTL3 was evaluated both in vitro and in vivo. Compared to fasting levels, the post-prandial serum TG level of all participants was considerably increased. Although post-prandial total cholesterol in HDL (HDL-C) remained unchanged, free cholesterol in HDL particles (HDL-FC) was significantly reduced after a meal. Furthermore, the post-prandial decrease in the HDL-FC level corresponded to the increase in remnant cholesterol (RC), indicating the possible exchange of free cholesterol between HDL and TRLs after a meal. Moreover, CAD patients with exaggerated TG response to diet, defined as TG increase >30%, tend to have a greater post-prandial increase of RC and decrease of HDL-FC compared to those with TG increase ≤30%. Mechanistically, the fasting and post-prandial serum ANGPTL3 levels were significantly lower in those with TG increase ≤30% than those with TG increase >30%, suggesting that ANGPTL3, the key lipolysis regulator, may be responsible for the different post-prandial responses of TG, RC, and HDL-FC.
The costs and value of modelling-based design in healthcare delivery: five case studies from the US

ABSTRACT In the nineties and noughties, Hollocks surveyed the use of Discrete Event Simulation (DES) in industry and listed (although he could not quantify the value of) benefits. This paper explores how DES is now used to design healthcare facilities and services, developing a value-for-money case with a protocol on collecting information. We present a set of five DES case studies from the US care system and, following Hollocks, focus on modelling as part of a rigorous design process, capturing as many of the benefits as possible. Healthcare offers the possibility of ascribing value to health improvement, but in these cases it is primarily the operational benefits of a better service that are reported and monetarised. By estimated the cost of modelling and the value of the operation gains, this paper contributes significantly to the literature. We conclude with a protocol for collecting information and a discussion of methods by which different types of benefit may be captured.
ENHANCE KNOWLEDGE COMMUNICATION AND LEARNING: A SURPRISE PARADOX

Human-computer interface is a pivotal factor that can promote or deter the effectiveness of Web-based knowledge communication. There is abundant research that strain to improve interfaces by considering user needs through usability studies; however, few researches consider the incorporation of automatic brain mechanisms in order to improve knowledge communication performance. The objective of this research is not to establish a relationship between the negative stimulus presence and improved knowledge communication, but rather to show that the shape of this function follows the Yerkes–Dodson Law. Partial least squares (PLS) was utilized to analyze the data. Results found in this study support the evidence that surprising negative events enhance knowledge communication effectiveness, but more importantly that the surprise-performance relationship is not a linear function but follows the inverted U shape
Developing Geometric Thinking through Activities That Begin with Play

Council of Teachers of Mathematics, Inc. www.nctm. org. All rights reserved. NCTM is not responsible for the accuracy or quality of the translation. ___________________________________________________________________________________________ ةيئادتبلاا ةلحرملا يف تايضايرلا يملعمل يرطقلا زآرملا افيح ةعماج / il . ac . haifa . 6 k mathcenter :// http 1 بعللا يف أدبت يتلا تايلاعفلا للاخ نم يسدنهلا ريكفتلا ريوطت
User-friendly tool for power flow analysis and distributed generation optimisation in radial distribution networks

The intent of power distribution companies (DISCOs) is to deliver electric power to their customers in an efficient and reliable manner – with minimal energy loss cost. One major way to minimise power loss on a given power system is to install distributed generation (DG) units on the distribution networks. However, to maximise benefits, it is highly crucial for a DISCO to ensure that these DG units are of optimal size and sited in the best locations on the network. This paper gives an overview of a software package developed in this study, called Power System Analysis and DG Optimisation Tool (PFADOT). The main purpose of the graphical user interface-based package is to guide a DISCO in finding the optimal size and location for DG placement in radial distribution networks. The package, which is also suitable for load flow analysis, employs the GUI feature of MATLAB. Three objective functions are formulated into a single optimisation problem and solved with fuzzy genetic algorithm to simultaneously obtain DG optimal size and location. The accuracy and reliability of the developed tool was validated using several radial test systems, and the results obtained are evaluated against the existing similar package cited in the literature, which are impressive and computationally efficient. Keywords: distribution networks, distributed generation, graphical user interface, PFADOT, fuzzy genetic algorithm, optimisation
Implementing visual management for continuous improvement: barriers, success factors and best practices

Visual management (VM) has become an important lean management practice for continuous improvement and has gained increasing attention from academics and practitioners. While operations management scholars have studied its benefits and functions, the factors that enable or hinder VM implementation have not been systematically investigated. Against this background, our study analyses qualitative case study data from Swiss manufacturing firms to reveal important barriers and success factors that are relevant for the implementation of VM. Moreover, for each success factor, we present several best practices observed in the case companies to overcome the associated barriers. The results contribute to the emerging field of VM within the lean management literature and provide insights for practitioners how to implement VM more effectively.
Experimenting the Effect of Psychological Inoculation as Intervention to Enhanced Self-Disclosure Outcomes Among Recently Diagnosed People Living with HIV

Abstract Non-disclosure of Human Immunodeficiency Virus (HIV) has been linked to medical (e.g. infection/treatment recuperation rate) and social (e.g. social support) related problems, and there is paucity of literature addressing the role of behavioral intervention in improving self-disclosure. This study examined the efficacy of Psychological Inoculation (PI) in enhancing self-disclosure. A randomized-clinical-trial design was adopted. Fifty-five respondents (39.5 ± 10.5 years) who scored below the mean ( = 45.30) on HIV-Self-disclosure Index were purposively assigned to study groups. The PI was effective in enhancing self-disclosure (effect size (np 2) = 0.35). However, individuals who received the refutation preemption variant ( = 78.18) and the supportive variant of PI ( = 75.18) reported higher disclosure than those who did not ( = 72.39). Psychological Inoculation was reported effective in enhancing self-disclosure. Psychological Inoculation should be incorporated into the existing treatment for HIV/AIDS.
A Systematic Review of Clinical Outcomes from Pharmacist Provided Medication Therapy Management (MTM) among Patients with Diabetes, Hypertension, or Dyslipidemia

This study aimed to compare the clinical outcomes of pharmacist-provided medication therapy management (MTM) services as compared to no MTM services (i.e., standard of care) on outpatient clinical outcomes for patients with diabetes, hypertension, or dyslipidemia. A systematic literature review of PubMed, EMBASE, Cochrane library, International Pharmaceutical Abstracts, PsycINFO, Scopus, CINAHL electronic databases, grey literature, websites, and journals, was conducted from 1 January 2005–20 July 2021. The search field contained a combination of keywords and MeSH terms such as: “medication therapy management”, “pharmacist”, “treatment outcomes”. Studies published in United States, included adults ≥18 years old who received at least one pharmacist-provided MTM consultation and at least one group who received no MTM, and reported pre-specified clinical outcomes for diabetes mellitus, hypertension, or dyslipidemia were included. Of 849 studies identified, eight were included (cohort studies = 6, randomized controlled trials = 2). Clinical outcomes improved with MTM interventions, as evidenced by statistically significant changes in at least one of the three chronic conditions in most studies. Improvements were observed for diabetes outcomes (n = 4 studies), hypertension outcomes (n = 4 studies), and dyslipidemia outcomes (n = 3 studies). Overall, this study indicated that pharmacist delivered MTM services (versus no MTM services) can improve clinical outcomes for patients with diabetes, hypertension, and dyslipidemia.
Migrant-Background Student Experiences of Facing and Overcoming Difficulties in Finnish Comprehensive Schools

This article considers what students with a migrant background in Finnish comprehensive schools report as difficult, and how they succeed in overcoming these difficulties. We draw on two sets of school wellbeing and learning surveys for migrant students, conducted in 2016 and 2021 in comprehensive schools (grades 1–9) in and around two major cities in Finland. We pay attention to student answers to three questions: What is difficult in school? How do you succeed in difficult tasks in school? and Who helps you in school? The datasets from the two points in time are compared to see whether changes in school demographic situation and the student length of stay in Finland had an impact on student experiences. Our findings show that theory-based school subjects that depend strongly on language, such as science subjects, maths, Finnish, Swedish and English, are considered difficult. Additionally, interaction with peers, which also relies on language, causes challenges. The students report turning to teachers, other professionals and peers for assistance and support, and also mention personal strategies they have developed to overcome school-related difficulties. Understanding what migrant students find difficult, as well as how, and with the help of whom, they overcome such difficulties is crucial for the development of effective and sensitive pedagogical practices.
Evaluation of Necessity of Cholesterol Supplementation in Diets of Two Marine Teleosts, Turbot (Scophthalmus maximus) and Tiger Puffer (Takifugu rubripes): Effects on Growth and Lipid Metabolism

Two 70-day feeding trials were conducted to reevaluate the necessity of cholesterol supplementation in diets of two important marine fish species, turbot and tiger puffer. Graded levels (0, 0.5, 1.0, 2.0, and 4.0% of dry matter) of cholesterol were added into the basal diet (with 30% fishmeal but no fish oil) to make five experimental diets, which were designated as control, CHO-0.5, CHO-1.0, CHO-2.0, and CHO-4.0, respectively. The dietary cholesterol concentration was measured to be 0.11%, 0.65%, 1.10%, 2.32%, and 4.59%, respectively. Each group had triplicate tanks, and each tank was stocked with 30 fish. The results showed that compared to the control, dietary cholesterol supplementation had no significant effect on the growth of both turbot and tiger puffer. Nevertheless, excess dietary cholesterol (CHO-2.0 and CHO-4.0) led to significant lower weight gain of tiger puffer compared to CHO-1.0. The feed intake decreased with increasing levels of dietary cholesterol. In general, the cholesterol supplementation decreased the crude lipid content in the liver, whereas 0.5% dietary cholesterol supplementation tended to increase the crude lipid content in the muscle of both species. Dietary cholesterol supplementation significantly regulated the lipid-related biochemical parameters in serum, liver, and muscle, and compared to turbot, tiger puffer lipid compositions had a higher buffering capacity in response to changes in dietary cholesterol level. Dietary cholesterol supplementation increased the 20:4n-6 content in the liver. Dietary cholesterol supplementation significantly downregulated the gene expression of HMG-COAr, upregulated the CYP7A1 expression, and downregulated the expression of lipid absorption and biosynthesis genes, but had no significant effect on gene expression of CPT1 and lipid transport-related genes (ApoA1, ApoA4, ApoB100, and ApoEα) in the liver. In conclusion, under the present experimental condition, dietary cholesterol supplementation had no significant effect on the growth of turbot and tiger puffer. In both species, dietary cholesterol supplementation significantly regulated the lipid accumulation and metabolism.