ALLERJİK HASTALIKLARI OLAN HASTALARDA OBEZİTE,C-REAKTİF PROTEİN (CRP) VE SERUM TOTAL IGE ARASINDAKİ İLİŞKİNİN DERİ PRİCK TESTİ SONUÇLARI İLE İLİŞKİSİ Association Between Obesity, C-Reactive Protein and Serum Total IgE with Skin Prick Test Results in Patients with Allergic DiseasesEconomic Situation

OZET Amac: Alerjik hastaligi olan hastalarda cilt prick test sonuclari ile serum total IgE, C-reaktif protein, vucut kitle indeksi arasindaki iliskiyi degerlendirmek. Metod: Bu calisma Ekim 2011 ile Eylul 2018 tarihleri arasinda universite hastanesinde yapildi. Astim, alerjik rinit, kronik urtiker ve atopik dermatit tanisi ile basvuran gogus hastaliklari klinigindeki 433 hastaya deri prik testi (DPT) uygulandi. Ayrica hastalarin serum total IgE, C-reaktif protein (CRP) duzeyleri ve vucut kitle indeksi olcumleri (BMI) degerlendirildi. Bulgular: Calisma grubu 433 hastadan olusmaktadir, 189'u (% 43,6) erkek, 244'u (% 56,4) kadindi. Taniya gore 177 (% 40,9) hastada astim, 108 (% 24,9) hastada alerjik rinit, 82 (% 18,9) hastada atopik dermatit ve 66'sinda (% 15,2) kronik urtiker vardi. SPT 285 (% 65,8) hastada pozitif, 148 (% 34,2) hastada negatif bulundu. En sik gorulen alerjenler % 23.2, ev tozu % 19.2, vahsi cimenlerde % 14.8 agac karisimiydi. DPT pozitif grupta total IgE, CRP ve BMI degerleri istatistiksel olarak daha yuksekti (p=0.001). Obez hastalarda istatistiksel olarak anlamli pozitif deri prik sonuclari vardi (p = 0.036). Ayrica pozitif total IgE ve CRP gruplari pozitif DPT grubunda anlamli olarak daha yuksekti (p =0.001 ve p = 0.008). Total IgE duzeyleri ile DPT arasinda orta duzeyde ve anlamli pozitif korelasyon vardi (r = 0.463, p=0.001). Ayrica CRP seviyeleri (r = 0.128, p = 0.008) ve obezite (r = 0.101, p = 0.036) dusuk seviyede ve DPT ile anlamli pozitif korelasyon gosterdi. DPT icin sadece total IgE istatistiksel olarak anlamli risk faktoru idi. Pozitif total IgE duzeyi, pozitif SPT olasiligini 8.11 kat arttirir. Sonuc: Bu calisma, yuksek total IgE, CRP ve obezite duzeylerinin, pozitif deri prik testi olasiliginin artmasiyla atopi ile iliskiye sahip olabilecegini gostermektedir. Pozitif total IgE duzeyi, deri prik test pozitifligi icin guclu bir prediktor olabilir. Anahtar kelimeler: Atopi; C-Reaktif Protein; Deri prik Testi; Obezite; Total IgE ABSTRACT Aim: To evaluate relationship between skin prick test results and serum total IgE, C-reactive protein, body mass index in patients with allergic diseases. Material and methods: This study was conducted in university hospital between October 2011 and September 2018. Skin Prick test (SPT) was applied to 433 patients in chest diseases clinic who were referred with diagnosis of asthma, allergic rhinitis, chronic urticaria and atopic dermatitis. Also patients’ serum total IgE, C-reactive protein (CRP) levels and body mass index (BMI) measurements were evaluated. Results: The study group were consisted of 433 patients, 189 (43.6%) male, and 244 (56.4%) female. According to the diagnosis, 177 (40.9%) patients had asthma, 108 (24.9%) had allergic rhinitis, 82(18.9%) had atopic dermatitis and 66 (15.2%) had chronic urticaria. SPT was positive in 285 (65.8%) patients while negative in 148(34.2%). Most frequently seen allergens were the mixture of trees 23.2%, home dust 19.2%, savage grass 14.8%. Total IgE, CRP, and BMI values were statistically higher in SPT positive group (p=0.001). Obese patients had statistically significant positive skin prick results (p=0.036). Also, positive total IgE and CRP groups were significantly higher in positive SPT group (p =0.001 and p=0.008). There was a moderate level and significant positive correlation between total IgE levels and SPT (r=0.463, p=0.001). Also CRP levels (r= 0.128, p=0.008) and obesity (r=0.101, p=0.036) had a low level and significant positive correlation with SPT. Only total IgE was the statistically significant risk factor for the SPT. Positive total IgE level increases the probability of positive SPT by 8.11 times. Conclusion: This study suggests that elevated levels of total IgE, CRP and obesity may have relationship with atopy by increased likelihood of positive skin prick test. Positive Total IgE level can be a strong predictor for skin prick test positivity. Key Words: Atopy; C-Reactive Protein; Obesity; Skin prick Test; Total IgE