Miracle-dz/UniFAR-FTUs huggingface dataset:
Neural-Network-Based Adaptive Resilient Dynamic Surface Control Against Unknown Deception Attacks of Uncertain Nonlinear Time-Delay Cyberphysical Systems

A neural-network-based dynamic surface design strategy against sensor and actuator deception attacks is presented to design a delay-independent adaptive resilient control scheme of uncertain nonlinear time-delay cyberphysical systems in the lower triangular form. It is assumed that all nonlinearities, time-varying delays, and sensor and actuator attacks are unknown. In the concerned problem, since the state information measured by sensors is compromised by additional attack signals, the exact state variables are not available for feedback. Thus, a memoryless adaptive resilient control design using compromised state variables is developed by employing the neural-network-based function approximation technique and designing the attack compensator. The resulting control scheme ensures the robust stabilization in the presence of unknown deception attacks and time-varying delays. It is shown from the Lyapunov stability analysis that all closed-loop signals are uniformly ultimately bounded and the stabilization errors converge to an adjustable neighborhood of the origin.
Genomic Outcomes of Haploid Induction Crosses in Potato (Solanum tuberosum L.)

The challenges of breeding autotetraploid potato (Solanum tuberosum) have motivated the development of alternative breeding strategies. A common approach is to obtain uniparental dihaploids from a tetraploid of interest through pollination with S. tuberosum Andigenum Group (formerly S. phureja) cultivars. The mechanism underlying haploid formation of these crosses is unclear, and questions regarding the frequency of paternal DNA transmission remain. Previous reports have described aneuploid and euploid progeny that, in some cases, displayed genetic markers from the haploid inducer (HI). Here, we surveyed a population of 167 presumed dihaploids for large-scale structural variation that would underlie chromosomal addition from the HI, and for small-scale introgression of genetic markers. In 19 progeny, we detected 10 of the 12 possible trisomies and, in all cases, demonstrated the noninducer parent origin of the additional chromosome. Deep sequencing indicated that occasional, short-tract signals appearing to be of HI origin were better explained as technical artifacts. Leveraging recurring copy number variation patterns, we documented subchromosomal dosage variation indicating segregation of polymorphic maternal haplotypes. Collectively, 52% of the assayed chromosomal loci were classified as dosage variable. Our findings help elucidate the genomic consequences of potato haploid induction and suggest that most potato dihaploids will be free of residual pollinator DNA.
Shortening Average Length of Stay Improve Medical Efficiency and Benefit in Hospital

Objective To shorten average length of stay and to improve medical efficiency and benefit by analyzing the average length of stay during ten years in our hospital. Methods Analyzing the data of the average length of stay,beds employed and medical costs. Result The average length of stay was in highly negative correlation with the number of discharge people,the beds velocity and the rate of beds employed. However,it had positive correlation with cure rate(this is related to the revised criteria of discharge). Also,the P-value showed the average length of stay had marked effect on the above indexes. During 1996-2005,along with the number of beds increased by 21.84%,the average length of stay dropped by 45.02%. In addition,the analysis revealed that the saved medical costs amounted to 202 840 000 RMB owing to the shortening of the average length of stay during the ten years. Conclusion Hospital managing as a whole is the guarantee of shortening of the average length of stay which should be on the basis of ensuring the medical quality. Shortening of the average length of stay is just a resort,the real aim is to fully utilize medical resources,to improve medical quality and medical efficiency and benefit.
Prognostic Value of c-Myc Immunohistochemical Expression in Muscle Invasive Urothelial Carcinoma of the Urinary Bladder: A Retrospective Study

Objective: This study aimed to investigate the immunohistochemical expression of c-Myc in muscle invasive urothelial carcinoma (MIUC) of the urinary bladder and to evaluate the correlation of c-Myc expression with different clinicopathological parameters and outcome, including a relatively new histopathological tumor characteristic that is the growth pattern of tumor invasion. Methods: A total of 66 formalin-fixed and paraffin-embedded sections of MIUC obtained from radical cystectomy specimens were enrolled. The sections were stained with c-Myc antibody using immunohistochemistry technique. Results: Tumor cells showed variability in nuclear c-Myc expression according to the growth pattern of invasion. The median H-score of nuclear expression of infiltrative pattern was significantly higher than that of non-infiltrative pattern (p<0.001). Nuclear expression of c-Myc in tumor tissue had a significant association with poor prognostic factors (sarcomatoid variant (p<0.001), perineural invasion (p=0.037), lymphovascular invasion (p<0.001), lymph node metastasis (p<0.001), distant metastasis (p=0.042) and advanced stage grouping (p=0.001). Kaplan Meier survival analysis demonstrated that c-Myc expression could not be significantly correlated with overall survival or disease free survival rates. Conclusion: Nuclear c-Myc seems to have a prominent role in epithelial to mesenchymal transition with consequential in tumor progression and metastasis, while it is not as much useful to predict the clinical behavior of patients with MIUC.
Physical space interacts with clonal fragmentation and nutrient availability to affect the growth of Salvinia natans

Physical space, clonal fragmentation and nutrient availability can each affect the growth of clonal plants, but their interactive effect has been little studied. We grew un-fragmented (connected) and fragmented (disconnected) ramet pairs of the floating, clonal plant Salvinia natans in cylindrical containers with different diameters and heights (volumes) filled with solutions of two nutrient levels (high vs. low). To simulate competition environments that are commonly confronted by S. natans, we also added two ramets of another floating plants Spirodela polyrrhiza in each container. Biomass (total biomass, floating biomass and submerged biomass) and number of ramets of S. salvinia were higher in the containers with a larger diameter. Compared to the low nutrient level, the high nutrient level increased number of ramets, and altered submerged to floating mass ratio of S. salvinia. The impacts of physical space on floating mass and number of ramets were stronger under the high than under the low nutrient level. Clonal fragmentation positively affected biomass in the containers with a smaller volume (a smaller height and diameter), but had little impact in the containers with a larger volume (a larger height or diameter). Our results suggest that physical space can interact with nutrients and clonal fragmentation to affect the performance of S. salvinia under competition.
A Survey of Computational Intelligence Techniques for Wind Power Uncertainty Quantification in Smart Grids

The high penetration level of renewable energy is thought to be one of the basic characteristics of future smart grids. Wind power, as one of the most increasing renewable energy, has brought a large number of uncertainties into the power systems. These uncertainties would require system operators to change their traditional ways of decision-making. This article provides a comprehensive survey of computational intelligence techniques for wind power uncertainty quantification in smart grids. First, prediction intervals (PIs) are introduced as a means to quantify the uncertainties in wind power forecasts. Various PI evaluation indices, including the latest trends in comprehensive evaluation techniques, are compared. Furthermore, computational intelligence-based PI construction methods are summarized and classified into traditional methods (parametric) and direct PI construction methods (nonparametric). In the second part of this article, methods of incorporating wind power forecast uncertainties into power system decision-making processes are investigated. Three techniques, namely, stochastic models, fuzzy logic models, and robust optimization, and different power system applications using these techniques are reviewed. Finally, future research directions, such as spatiotemporal and hierarchical forecasting, deep learning-based methods, and integration of predictive uncertainty estimates into the decision-making process, are discussed. This survey can benefit the readers by providing a complete technical summary of wind power uncertainty quantification and decision-making in smart grids.
Mitochondria Segmentation From EM Images via Hierarchical Structured Contextual Forest

Delineation of mitochondria from electron microscopy (EM) images is crucial to investigate its morphology and distribution, which are directly linked to neural dysfunction. However, it is a challenging task due to the varied appearances, sizes and shapes of mitochondria, and complicated surrounding structures. Exploiting sufficient contextual information about interactions in extended neighborhood is crucial to address the challenges. To this end, we introduce a novel class of contextual features, namely local patch pattern (LPP), to eliminate the ambiguity of local appearance and texture features. To achieve accurate segmentation, we propose an automatic method by iterative learning of hierarchical structured contextual forest. With a novel median fusion strategy, the probability predictions from long history iterations are augmented to encode spatial and temporal contexts and suppress false detections. Moreover, the LPP features are extracted on both images and history predictions, resulting in a hierarchy of contextual features with increasing receptive fields. Other than using computationally demanding graph based methods, we perform joint label prediction using structured random forest. In addition to direct 3D segmentation of EM volumes, we introduce a 2D variant without sacrificing accuracy using a novel hierarchical multi-view fusion strategy. We evaluated our proposed methods on public EPFL Hippocampus benchmark, achieving state-of-the-art performance of 90.9% in Dice. Quantitative comparison showed the effectiveness of the proposed features and strategies.
Clostridioides difficile Infection Induces an Inferior IgG Response to That Induced by Immunization and Is Associated with a Lack of T Follicular Helper Cell and Memory B Cell Expansion

The intracellularly active bacterial toxin TcdB is a major Clostridioides difficile virulence factor that contributes to inflammation and tissue damage during disease. Immunization with an inactive TcdB fragment prevents C. difficile infection (CDI)-associated pathology. The protective immune response against inactive TcdB involves development of antigen-specific memory B cells and long-lived plasma cells that encode TcdB-neutralizing antibodies. Unlike the response to inactive TcdB, very little is known about the host humoral immune response to C. difficile and TcdB during primary and recurrent infection. ABSTRACT The intracellularly active bacterial toxin TcdB is a major Clostridioides difficile virulence factor that contributes to inflammation and tissue damage during disease. Immunization with an inactive TcdB fragment prevents C. difficile infection (CDI)-associated pathology. The protective immune response against inactive TcdB involves development of antigen-specific memory B cells and long-lived plasma cells that encode TcdB-neutralizing antibodies. Unlike the response to inactive TcdB, very little is known about the host humoral immune response to C. difficile and TcdB during primary and recurrent infection. Here, we used a murine model of C. difficile disease recurrence to demonstrate that an initial infection induced a serum IgM and mucosal IgA response against the toxin, but a low serum IgG response, which is associated with a lack of protection against disease during reinfection. Infection induced a partial expansion of the T follicular helper cell compartment, essential for B cell memory responses, and, consistent with that, failed to significantly expand the memory B cell compartment. Further, infection failed to stimulate the memory B cell compartment in preimmunized mice, although they were protected against associated disease. These results delineate the key humoral immune events that follow primary and recurrent C. difficile infection and provide a compelling inverse correlation between B cell memory and disease recurrence.
Commonly missed nursing cares in the obstetrics and gynecologic wards of Tigray general hospitals; Northern Ethiopia

Background Missed nursing care is considered an error of omission and is defined as any aspect of required patient care that is omitted (either in part or whole) or significantly delayed. Nursing care missed in the perinatal setting can cause negative outcomes and repercussions for the quality and safety of care. This has been reported in multiple settings and countries and is tied to negative maternal outcomes. Preventing missed nursing care requires in-depth research considering the clinical setting. Objective The main aim of the study was to assess commonly missed nursing care elements, reasons, and factors for the omission in the obstetric and gynecologic units of general hospitals in Tigray 2017/18. Methods and materials A cross-sectional study was conducted in eight randomly selected general hospitals in Tigray, Ethiopia. A total of 422 nurses and midwives were selected through simple random sampling using the staff list as a sampling frame. To identify the commonly missed nursing care and related factors, the MISSCARE survey tool was used. Descriptive, bivariate, and multivariate logistic regression analysis was performed to assess potential risk factors of nursing cares omission. Result The study results showed that 299 (74.6%) participants commonly missed at least one nursing care in the perinatal setting. Labor resources 386(96.3%), teamwork 365(91%), material resources 361 (90%) and communication 342 (85.3%) were the reasons identified for commonly missing care. In the multivariate analyses, sex (p-value <0.001), educational level (p-value 0.034), working shift (p-value <0.001) and having an intention to leave the institution (p-value <0.001) showed a significant association with commonly missing care. Conclusion The proportion of commonly missed nursing care was high. After adjusting for demographic variables, labor resources, material resources, and communication were reasons for commonly missed nursing care. Increasing male professional proportion, investing in nurses/midwives training, and harmonizing nursing service administration through appropriate working shift arrangement and timely assessment of professionals’ stability and satisfaction could minimize frequent omission of nursing care.
Gpr126/Adgrg6 contributes to the terminal Schwann cell response at the neuromuscular junction following peripheral nerve injury

Gpr126/Adgrg6 is an adhesion G protein‐coupled receptor essential for Schwann cell (SC) myelination with important contributions to repair after nerve crush injury. Despite critical functions in myelinating SCs, the role of Gpr126 within nonmyelinating terminal Schwann cells (tSCs) at the neuromuscular junction (NMJ), is not known. tSCs have important functions in synaptic maintenance and reinnervation, and after injury tSCs extend cytoplasmic processes to guide regenerating axons to the denervated NMJ. In this study, we show that Gpr126 is expressed in tSCs, and that absence of Gpr126 in SCs (SC‐specific Gpr126 knockout, cGpr126) results in a NMJ maintenance defect in the hindlimbs of aged mice, but not in young adult mice. After nerve transection and repair, cGpr126 mice display delayed NMJ reinnervation, altered tSC morphology with decreased S100β expression, and reduced tSC cytoplasmic process extensions. The immune response promoting reinnervation at the NMJ following nerve injury is also altered with decreased macrophage infiltration, Tnfα, and anomalous cytokine expression compared to NMJs of control mice. In addition, Vegfa expression is decreased in muscle, suggesting that cGpr126 non‐cell autonomously modulates angiogenesis after nerve injury. In sum, cGpr126 mice demonstrated delayed NMJ reinnervation and decreased muscle mass following nerve transection and repair compared to control littermates. The integral function of Gpr126 in tSCs at the NMJ provides the framework for new therapeutic targets for neuromuscular disease.
Adherence to the World Cancer Research Fund/American Institute for Cancer Research cancer prevention guidelines and colorectal cancer incidence among African Americans and whites: The Atherosclerosis Risk in Communities study

Adherence to the World Cancer Research Fund (WCRF)/American Institute for Cancer Research (AICR) cancer prevention recommendations is associated with colorectal cancer (CRC) risk in whites, but only 1 previous study has reported on this link in African Americans. This study assessed the association between the 2018 WCRF/AICR guidelines and CRC incidence in African Americans (26.5%) and whites (73.5%) in the Atherosclerosis Risk in Communities prospective cohort (n = 13,822).
Enamel defects and caries prevalence in preterm children aged 5-10 years in Dubai

ABSTRACT Background: Enamel defects (EDs) are commonly reported dental findings in preterm/low birthweight children. EDs potentially increase caries susceptibility. Aim: To assess the prevalence of EDs and dental caries in a group of preterm children (aged 5–10 years) in Dubai, United Arab Emirates (UAE). Methodology: A retrospective cohort study of medical records of 62 preterm children (mean age 8.1 ± 1.54) and 62 full-term children (mean age 8.1 ± 1.73) of both genders born in a UAE children’s hospital were studied. These children were dentally assessed for EDs and caries by a calibrated examiner. Results: EDs were 4.34 times more prevalent among preterm children [odd ratio (OR) = 4.338, CI 95% [2.010–9.366]. The prevalence of EDs in the pre-term group was 58.15%, significantly higher (P < 0.01) than the full-term control group (24.2%). Birth weight, intubation and type of delivery were statistically significant factors contributing to EDs. In the primary dentition, the mean dmft was 4.61 ± 4.30, while in the permanent dentition DMFT was 0.38 ± 0.99. There was a statistically significant difference in permanent teeth caries experience amongst pre-term children compared to the full-term control as measured by DMFT (P = 0.008). Conclusion: EDs and dental caries in permanent dentition in the pre-term group were significantly higher than the full-term group.
When we increase fear, do we dampen hope? Using narrative persuasion to promote human papillomavirus vaccination in China

This study examines the use of narrative persuasion in promoting human papillomavirus vaccination. Compared to non-narrative message, the narrative message increased perceived severity of human papillomavirus, which influenced vaccination intention through heightened fear. The narrative message also dampened hope and subsequently decreased vaccination intention. This research attests to the effectiveness of narrative persuasion in vaccination promotion, but also offers important caveat for message design—egocentric efficacy information is crucial in narrative persuasion designed to motivate preventive health behaviors.
A Case of Infected Left Atrial Myxoma Presenting as ST-Elevation Myocardial Infarction (STEMI)

Patient: Male, 34-year-old Final Diagnosis: Infected atrial myxoma Symptoms: Chest pain Medication: — Clinical Procedure: — Specialty: Cardiology Objective: Rare disease Background: Although left atrial myxoma is the most common benign primary cardiac tumor, infected atrial myxoma is rare. This report presents a case of infected left atrial myxoma with embolization to the left anterior descending (LAD) coronary artery, which was identified following an initial presentation with ST-elevation myocardial infarction (STEMI). Case Report: A 34-year-old man with a history of smoking tobacco and intravenous cocaine use presented to the emergency room with symptoms of a feeling of pressure on the chest and symptoms in the left arm. An electrocardiogram (ECG) showed ST elevation in leads II, III, aVF, and V3–V5, consistent with an anterior-inferior STEMI. He underwent percutaneous intervention (PCI) with two drug-eluting stents to the mid-distal LAD coronary artery. The patient also had fever, chills, a history of weight loss, and signs of peripheral emboli. Blood cultures identified Gram-positive Streptococcus parasanguinis, a member of the Streptococcus viridans group. Transesophageal echocardiogram (TEE) identified a large, mobile, pedunculated left atrial mass protruding into the mitral valve in diastole and mitral valve vegetations. Surgical excision and the histology confirmed a diagnosis of benign left atrial myxoma containing Gram-positive cocci. The patient required mitral valve replacement and a postoperative two-week course of gentamicin and a six-week course of ceftriaxone Conclusions: A rare case is reported of infected left atrial myxoma presenting as STEMI secondary to coronary artery embolization, which was treated with PCI, antibiotics, and mitral valve replacement.
Living Donor Liver Transplantation When Deceased Donor Is Not Possible or Timely: Case Examples and Ethical Perspectives

This article analyzes the ethical soundness of living donor liver transplantation (LDLT) in situations where the transplant team does not consider deceased donor liver transplantation (DDLT) a clinical or timely option. Given that patients with end‐stage liver disease have a high risk of death without DDLT, the option of LDLT becomes compelling and may save lives. We present 3 representative cases from our center that raise concerns over social behavior, limited time constraints for decision making, and high potential for disease recurrence that render DDLT an unlikely option. Thereafter, we discuss ethical issues for each patient, which predominantly pertain to compromises to the living donor informed consent process and the feasibility of LDLT. We conclude with recommendations regarding whether LDLT is an acceptable ethical option for those patients, which may inform clinical practice in the broader transplant community.