Miracle-dz/UniFAR-FTUs huggingface dataset:
The Escalation of Osteosarcoma Stem Cells Apoptosis After the Co-Cultivation of Peripheral Blood Mononuclear Cells Sensitized with Mesenchymal Stem Cells Secretome and Colony Stimulating Factor-2 in vitro

Introduction Peripheral blood mononuclear cells (PBMCs) sensitized with mesenchymal stem cells (MSCs) secretome and/or colony stimulating factor-2 (CSF-2) as an immunotherapy candidate may escalate osteosarcoma stem cells (OS-SCs) apoptosis. This study aimed to investigate the escalation of osteosarcoma stem cells’ apoptosis after the co-cultivation with PBMCs sensitized by MSCs secretome with/or CSF-2 and it was completed by analyzing the level of serum tumor necrosis factor-related apoptosis-inducing ligand (sTRAIL) and tumor necrosis factor-α (TNF-α) level, annexin V binding, caspase-3 and caspase-8 expression in vitro. Methods OS-SCs were derived from a single human osteosarcoma sample with its high grade and osteoblastic essential clinical characteristics obtained from a biopsy before the chemotherapy treatment. They were then isolated and cultured confirmed by the cluster of differentiation-133 (FITC) by applying immunofluorescence analysis with fluorescein isothiocyanate (FITC) labeled. MSCs secretome was obtained with cells extracted from the bone marrow of a healthy patient. Furthermore, enzyme linked immunosorbent assay (ELISA) was utilized to analyze sTRAIL and TNF-α level in each group. The expression of caspase-3, caspase-8, and annexin V assay in each group was examined by applying the immunofluorescence labeled with FITC. The comparison analysis between treatment groups and the control group was performed by utilizing the analysis of variance (ANOVA) and continued with Tukey Honest Significant Difference (HSD) (p<0.05). Results There was a significant difference in the upregulation of sTRAIL and TNF-α level indicated by the increased annexin V, caspase-3, and caspase-8 expression binding between groups (p<0.05). Conclusion MSCs Secretome and CSF-2 could significantly increase the activity of PBMCs through the improvement of sTRAIL and TNF-α levels which could lead to the escalation of OS-SCs apoptosis through an enhanced expression of caspase 3, caspase 8 and annexin V binding in vitro.
Connecting Peripheral to Central Neuropathy: Examination of Nerve Conduction Combined with Olfactory Tests in Patients with Type 2 Diabetes

Aim Few studies have investigated the associations between diabetic peripheral neuropathy (DPN) and cognitive decline. Olfactory impairment is related to neurodegenerative diseases and type 2 diabetes mellitus (T2DM); however, the cognitive alterations of patients with DPN and the role of olfactory function in DPN are not known. We explored alterations in cognition with DPN and the associations of neuropathy parameters with cognition and olfaction. Methods Healthy controls (HCs) and patients with T2DM underwent nerve-conduction tests, detailed cognitive assessment, olfactory-behavior tests, and odor-induced functional magnetic resonance imaging (fMRI). T2DM patients were divided into two groups (non-DPN [NDPN] and DPN). Olfactory brain regions showing different activation between the two groups were selected for functional connectivity (FC) analyses. A structural equation model (SEM) was also generated to demonstrate the association among cognition, olfactory, and neuropathy parameters. Results One hundred individuals (36 HCs, 36 NDPN, and 28 DPN) were matched for age, sex, and educational level. Compared with the NDPN group, the DPN group had significantly lower scores for memory and processing speed, as well as lower olfactory identification and memory scores, decreased activation of the left frontal lobe, and reduced seed-based functional connectivity in the right insula. The nerve conduction velocity in patients with T2DM was associated with cognitive functions. The association between nerve conduction and executive function was mediated by olfactory behavior. Conclusion Patients with DPN had worse cognition than the NDPN patients in the domains of memory and processing speed. Cognitive dysfunction could be predicted by olfactory-behavior tests and electrophysiological examination.
In The Line of Treatment: A Systematic Review of Paroxysmal Supraventricular Tachycardia

Paroxysmal supraventricular tachycardia (PSVT) is a common tachyarrhythmia, and an electrocardiogram is the best tool for making a diagnosis. If Valsalva maneuvers and carotid sinus massage do not give positive results, then the next choice is either adenosine or calcium channel blockers. At this time, adenosine is the drug of choice of treatment. Verapamil and diltiazem are the most commonly used calcium channel blockers (CCBs). This review aimed to compare the efficacy of both drugs in the treatment of PSVT. We utilized the databases PubMed Central and Medline by using keywords: "calcium channel blockers OR adenosine AND supraventricular tachycardia. " In the end, we finalized 32 studies, including observational studies, literature reviews, systematic reviews/metanalysis, and randomized control trials. We included articles only in the English language and related to humans. Two authors completed the quality assessment and evaluation of bias according to specific guidelines. Only high-quality studies were included in this systematic review based on the cut-off score of seven or above. Calcium channel blockers have a longer half-life than adenosine and were previously used as the drug of choice in the treatment of PSVT. Calcium channel blockers are safe if given slowly; however, adenosine is safer and useful when an electrocardiogram is uncertain. We compared both drugs in certain aspects and found equal efficacy. Though safer, adenosine was found to have a higher cost and a higher probability of re-initiation arrhythmia compared to calcium channel blockers.
Risk of musculoskeletal disorders in pepper cultivation workers

Agricultural workers have an increased risk of musculoskeletal disorders, mainly due to the manual nature of the work. This study assesses the level of physical well-being in pepper cultivation workers in Almería (Spain). The objective was to analyze pepper cultivation tasks performed in the Almería-type greenhouse, using the OWAS (Ovako Working Posture Assessment System) and RULA (Rapid Upper Limb Assessment) methods. The OWAS results showed a normal posture percentage of 53 %, a medium risk of 30 %, a high risk of 16 %, and a very high risk of 1 %. The body areas most affected were the back and legs. The RULA assessment found high risk/action levels, with 50 % of the postures corresponding to level 3, 35 % to level 4, and 15 % to level 2. Improvements are therefore proposed; these include: redesigning tasks, mechanization, training, team development, and improving the workers' physical condition. The OWAS and RULA data may have overestimated the results, as workers do not appear to be limited in performing tasks and do not normally request sick leave.
Effect of supercritical CO2 extraction process parameters on oil yield and pigment content from by-product hemp cake

This research gives an insight into the possibility of exploiting the one of the food industry’s by-products - pressed hemp cake. The complete recovery of oil from pressed hemp cake was achieved. Residual oil that remained in cake after pressing was extracted with supercritical CO2 by applying different process parameters. Optimal extraction conditions were determined using response surface methodology. Total pigment contents of the oils obtained were determined. Extraction pressure had the most significant influence on yield and pigment content of extracted hemp cake oil. Depending on the pressure, the chlorophyll a content ranged from 101.11 to 378.28 mgkg-1 and chlorophyll b from 65.14 to 189.78 mgkg-1, while total carotene content was in the range from 33.58 to 132.67 mgkg-1. The remaining oil in pressed hemp cake after supercritical CO2 extraction was determined to be 0.56 ± 0.08% and the defatted cake was rich in proteins and fibre.
Microwave Absorption Enhancement of Porous Carbon Fibers Compared with Carbon Nanofibers

Porous carbon fibers (pores of: 0.1–3 μm in diameter) and carbon nanofibers (∼100 nm in diameter) were prepared from polyacrylonitrile/polymethyl methacrylate (PAN/PMMA) blend fibers with 70/30 and 30/70 weight ratio, respectively, as precursors. The composites containing 2–6 wt % porous carbon fibers or carbon nanofibers as microwave absorbents were fabricated. The complex permittivity of these composites was measured, and the microwave absorption properties were stimulated based on a model for a single-layer plane wave absorber. We found that composites filled with the porous carbon fibers exhibited a much better performance in microwave absorption than those containing the carbon nanofibers. Composites containing 6 wt % porous carbon fibers or carbon nanofibers showed the lowest reflection loss of −31 dB at 9.7 GHz and −12.2 dB at 10.7 GHz, respectively. The bandwidth with reflection loss below −5 dB covered the whole X band (4.2 GHz) in the former case, whereas it was only 2.6 GHz in the latter case, .
A Closer Look at the Emotional Intelligence Construct: How Do Emotional Intelligence Facets Relate to Life Satisfaction in Students Involved in Bullying and Cyberbullying?

Adolescents’ perception of their own emotional abilities has been related to psychological adjustment and well-being. However, there are still few studies focusing on specific emotional dimensions in relation to bullying and well-being in adolescence. This study analysed the relationship between emotional intelligence (EI) facets, satisfaction with life, bullying and cyberbullying in adolescents. The sample consisted of 3520 high school students (51.5% females) aged between 12 and 18 years (M = 14.37; SD = 1.67). The correlation analyses showed that the majority of EI facets were positively related to satisfaction with life and negatively with both types of violence. As was expected, bullying and cyberbullying victims and bully–victims scored lower in satisfaction with life and the majority of EI facets. Controlling for sex, age, and grade, self-emotion appraisal, use of emotions and regulation of emotion were the best predictors of life satisfaction in bully–victims of bullying and cyberbullying. Finally, we discuss the relevance of these findings for clinical and educational practice on EI seeking to promote subjective well-being among adolescents involved in bullying and cyberbullying.
Continuous‐flow microwave enhanced oxidation process for treating sewage sludge

The microwave-enhanced advanced oxidation (MW/H2O2-AOP) treatment of sewage sludge in a continuous-flow 915 MHz microwave system was studied. A higher H2O2 dosage at the same flow rate resulted in better solids disintegration in terms of higher soluble chemical oxygen demand. The highest soluble chemical oxygen demand concentration of 5174 mg/L was obtained at a dosage of 0.005 L/L (0.5 % v/v). A higher soluble chemical oxygen demand was obtained at a higher flow rate with the same H2O2 dosage. A substantial amount of soluble phosphorus (over 60 % of total phosphorus content) was produced for all treatments, regardless of H2O2 dosage. A first-order reaction kinetics of soluble chemical oxygen demand was proposed in this study. Real-time energy consumption corresponding to performance efficacy, which provides a realistic assessment of the process efficiency, was calculated. Energy consumption was found to vary between 0.22–0.29 kWh/L of sludge treated. The results demonstrated that a continuous-flow 915 MHz microwave system resulted in high treatment efficiency in terms of nutrient release, solids disintegration, and low energy consumption, which is suitable for real-time industrial applications.
Effects of Polyoxymethylene as a Polymeric Nucleating Agent on the Isothermal Crystallization and Visible Transmittance of Poly(lactic acid)

In this work, use of polyoxymethylene (POM) as a polymeric nucleating agent for poly(lactic acid) (PLA) was studied. The compounding was performed using a twin-screw extruder. Effects of POM on isothermal crystallization of PLA at temperatures ranging from 106 °C to 111 °C and visible transmittance of PLA were examined in detail with various techniques, including polarized optical microscopy, differential scanning calorimetry (DSC), X-ray diffraction (XRD), and ultraviolet–visible (UV-vis) spectroscopy. Banded spherulites were noted when the POM content exceeded 5 wt %. The presence of POM generally resulted in effective reductions in the half time of crystallization and the spherulite size of PLA. However, 1% POM was a threshold for the nucleating effect: at ≤1% POM, no nucleating effect was observed. Fourier transform infrared (FTIR) spectroscopy revealed the strong interaction between the two polymers. The Avrami modeling suggested a three-dimensional crystal growth at all temperatures and loading leve.
Roles of Malondialdehyde and Catalase in Serum of Urolithiasis

The current study is conducted to determine the level of malondialdehyde (MDA) as an index of free radicals induced lipid peroxidation and catalase as an index of antioxidant enzyme in the serum of patients with urolithiasis. Significantly high level of MDA (p < 0.05) and significantly low level of catalase (p < 0.05) were observed in the serum of urolithiasis patients as compared to normal controls. There was no difference in serum level of MDA and CAT between male and female neither in patients nor controls. Also, there were no correlation between the serum MDA and serum CAT in both patients and controls. Among patients, 21.7% were smokers. There was no significant difference between smokers and non smokers patients regarding serum level of MDA and CAT. In conclusion, it appears that a role of lipid peroxidation and oxidative function exists in the pathogenesis of urolithiasis, but its mechanism is unknown. ﺔﺼﻼﺨﻟﺍ ﺩﻴﺎﻬﻴﺩﻷﺍ ﻱﺍﺩ ﻥﻭﻟﺎﻤﻟﺍ ﺭﻭﺩ ﺔﺴﺍﺭﺩﻟ ﺙﺤﺒﻟﺍ ﺍﺫﻫ ﻊﻀﻭ ﺩﻘﻟ
Primary Breakup of Liquid Jet in an Annular Passage in Crossflow of Air

This paper presents an experimental study of primary breakup of liquid jet in an annular passage in a cross flow of air at a fixed Mach number of 0.12, at atmospheric pressures. The experiments were conducted for various velocities of liquid jet from 1.417 m/s to 7.084 m/s (based on orifice diameter = 1 mm) and the corresponding liquid-air momentum flux ratios varied from 1 to 25. The droplet sizes and velocities were measured using a Phase Doppler Particle Analyzer (PDPA) downstream of the liquid inlet port along the axial direction at the centerline of the annular passage along the plane of injection. Observed droplet sizes and velocity variations at different momentum flux ratios, in the axial direction, show three distinct zones. The first zone is the ligament formation zone represented by large variation in droplet Reynolds number with momentum ratio. The second zone is the primary droplet formation zone in which a fairly monotonic decrease in droplet size and droplet acceleration due to the breakup is observed. However, the Reynolds number of the droplets is almost invariant with momentum ratio. The third zone is where the spray attains the critical state where the size and velocity does not vary in the axial direction and the variation in size in this zone with the momentum ratio is primarily due to the initial conditions established in the ligament formation zone.Copyright © 2015 by ASME
A culture of collaboration: Forms and factors affecting collaboration between NESTs and NNESTs in extracurricular English activities

Fulbright English Teaching Assistants (ETAs) assist local English teachers to further the English language development of students around the globe, while simultaneously acting as cultural ambassadors for the United States. ETAs in Indonesia are required to spend between twenty and twenty-five hours each week in the classroom with their teaching counterpart(s) but are also encouraged to engage with their school and community outside of class, and as such many ETAs also spend considerable time developing extracurricular English programming. While some of these extracurriculars are facilitated independently by the ETAs, many are collaborative projects with counterparts from the host institution. As part of a larger five-year research plan initiated by the American Indonesian Exchange Foundation (AMINEF) that seeks to explore the impact of ETAs, this research explores the collaboration within these extracurriculars. It seeks to identify the forms that this collaboration takes, as well as the factors that affect the collaboration. The findings suggest that collaboration within these extracurriculars usually takes the form of either one teach – one assist model, or team teaching, and that logistical and interpersonal factors are of the greatest concern within the collaboration.
TRACER TESTING AT SOULTZ-SOUS-FORÊTS (FRANCE) USING NA-BENZOATE, 1,5 AND 2,7-NAPHTHALENE DISULFONATE

A hydraulic stimulation was conducted in well GPK-2, at Soultz-sous-Forets (France), in July 2000, one year after its deepening from a depth of 3,500 m to 5,100 m. During this operation, two organic tracers (Na-benzoate and 1,5-naphthalene disulfonate) were continuously injected at a controlled concentration of about 2 mg/l into GPK-2 with around 26,800 m 3 of fresh water. The chemical composition of this water is very different from that of the geothermal brine (NaCl fluid with a TDS close to 100 g/l). Four shortterm production tests were carried out between December 2000 and April 2002. The fluid produced from GPK-2 was geochemically monitored during these tests. This paper presents the main results of that fluid monitoring. Comparison with natural tracers such as chloride indicated that the organic tracers were remarkably stable during more than 2 years at around 200°C. At each production test, the mass proportions of injected fresh water and geothermal brine could be estimated; the recovered fresh water could also be calculated (less than 7% relative to the total volume of fresh water injected into GPK-2). It was observed that the injected fresh water was internally replaced by the geothermal brine in the reservoir. The mean flow rate of the geothermal brine circulation could be estimated at 1-1.2 m 3 /h. Between January and March 2003, and during another operation of hydraulic stimulation, a third tracer (2,7-naphthalene disulfonate) was injected into GPK-2 at a controlled concentration of about 3 mg/l, with about 24,000 m 3 of fresh water. The detection of 1,5-nds, almost 3 years after its injection into GPK-2, and that of 2,7-nds in the fluid discharged from GPK-3, have shown that the recently drilled GPK-3 well (depth of 5,100 m) is directly connected to GPK-2.
Effects of Metformin on Pregnancy Outcomes in Women with Polycystic Ovary Syndrome during First Trimester

Background: Polycystic ovary syndrome is a hormonal disorder commonly found in women of reproductive age affecting about 15% of them and is considered the most common cause of anovulatory infertility. Administration of metformin to these anovulatory women increase ovulation rate and continuing in first trimester improves the pregnancy outcome. Objective: To assess pregnancy outcome in women with polycystic ovary syndrome who continue metformin during first trimester with its co-morbidity and mortality. Patients and Methods: This prospective intervention study was conducted on 44 pregnant polycystic ovary syndrome women who were attending for antenatal care at Outpatient Clinic, Obstetric and Gynaecological Department, Zagazig University Hospital. These 44 women took metformin before pregnancy and was followed up by indication of ovulation and metformin (1000-1500 mg/day) until they got pregnant. Then they were divided into two group: group 1 (22) continuous metformin dose during first trimester and group 2 (22) who discontinued metformin therapy once pregnancy diagnosed. The 2 groups followed up by fasting blood glucose and fasting serum insulin at their first visit and at 28 weeks of gestation. Results: group 1 who continued (1000_1500mg /day) metformin in first trimester had good pregnancy outcomes (significantly lower weight gain, lower gastrointestinal diabetes mellitus and lower spontaneous miscarriage) than group 2 who discontinued metformin (p value: 0.001). Conclusions: good maternal outcomes in women with polycystic ovary syndrome who continued metformin during first trimester including decrease incidence of spontaneous miscarriage and gastrointestinal diabetes mellitus.
Low Cost Sensor Node for Monitoring River Floods

<p>River floods occupy a respectable percentage among all natural disasters, are presenting high risk, and usually cause great damage. Important tools in managing and preventing river floods are the Early Warning Systems (EWS), which are usually consisted both by a hardware infrastructure (sensors, communication network) and a relevant software infrastructure (data logging, signal processing, modeling, risk detection). </p><p>In the current work we are presenting preliminary results from a novel, low-cost and low-power hardware system, part of a EWS aimed for river floods. The system consists of multiple sensing nodes, each to be strategically positioned at certain points along the route of river Evros, Greece. Each sensing node will bear a low-cost and high-quality ultrasonic water level sensor, along with an embedded microcomputer to control its functionality. An additional novelty of the proposed work is the design and utilization of a private low-power wide-area wireless network (LPWAN), taking advantage of IoT technologies and especially the LoRaWAN implementation. This way, the proposed system will have even lower power demands, together with greater expandability by allowing many nodes to be simultaneously connected and measuring, and having the ability to utilize crowd-sensing techniques. The power supply is battery based and autonomously recharged with the aid of small solar panel. Each node will measure the water level of the river, and upload the data to a cloud server at variable time intervals, depending on the actual water level variation and the system&#8217;s power consumption optimization. </p><p>Future upgrades of the system will involve extra sensors, allowing the nodes to measure water quality parameters i.e. suspended solids, pH, etc. Although of secondary importance, these parameters might prove to be important in the development of the risk detection and alarm issuing algorithms. </p>
Rate Constants for the Reactions of XO3-(H2O)n (X = C, HC, and N) and NO3-(HNO3)n with H2SO4: Implications for Atmospheric Detection of H2SO4

Relative rate constants for the reactions of CO3-(H2O)n, HCO3-(H2O)n, NO3-(H2O)n, and NO3-(HNO3)n with H2SO4 have been measured for n = 0−2, 0−2, 0−3, and 0−3, respectively. All rate constants have been found to occur in the ratio expected for the collisional values. This strongly indicates that the reactions proceed at the collision rate, and we assign absolute rate constants on the basis of this assumption. The present results show that all ions previously used for chemical ionization detection of H2SO4 concentrations in the atmosphere react rapidly, as has been previously assumed.