Miracle-dz/UniFAR-FTUs huggingface dataset:
Role of electromagnetic analysis in radiative immiscible Newtonian and non‐Newtonian fluids through a microchannel with chemical reactions

The study of an immiscible fluid plays a significant role in the field of petroleum extraction, blood flow in arteries, hydrology, manufacturing process, and reservoir mechanics. These phenomena include immiscible fluids of different densities and viscosities in the same channel. Due to the various practical applications, in the current study, the generalized Couette flow of two immiscible fluids (Newtonian and non‐Newtonian fluids) of different viscosities between two infinite parallel plates under the presence of constant pressure gradient and electroosmosis is addressed. The effects such as electromagnetohydrodynamics, zeta potential, Joule heating, thermal radiation, modified Darcy's law, and chemical reaction have been also considered into account. The dimensional system of equations has been nondenationalized with suitable dimensionless quantities. The resulting nondimensional system of coupled flow equations has been solved analytically. The solutions for the velocity, temperature, and concentration have been presented. The effect of various pertinent fluid flow parameters has been displayed graphically. The current study concludes that both the velocity and temperature profiles decrease with the increase in Hartmann number and radiation parameter, whereas an increase in chemical reaction parameter uplifts the concentration of both fluids.
Information externalities, analyst research resource allocation, and stock pricing efficiency

ABSTRACT Information is key to decision-making and is a major determinant of investment performance. We hypothesise that as analysts are constrained by their research resources, they collect information with more externalities. Measuring information externalities as a stock’s fundamental correlations with other stocks in the same industry, we find that stocks with high information externalities get more analyst coverage, more (high-quality) analyst reports, and more site visits than those with low information externalities. At the analyst level, we find consistent evidence that individual analysts allocate more effort to firms with high information externalities in their stock portfolios. Consequently, we further demonstrate that stocks with high information externalities are associated with less information delay and are priced more efficiently.
Mindfulness-Based Interventions in People with Psychotic Disorders: An Overview of the State of Research Concerning Efficacy and Implications for Clinical Practice

Mindfulness-based interventions (MBI) represent a central pillar of the third wave of Cognitive Behavioral Therapy. In recent years, MBI have been implemented in treating patients with psychotic disorders, and their efficacy has been evaluated in a small number of randomized-controlled trials (RCTs). This narrative review presents the current state of research on the efficacy and effectiveness, as well as central aspects of the clinical applications of MBI in the treatment of patients with schizophrenia and primary psychotic disorders. Current meta-analyses show different results but concur that in comparison to controls with treatment-as-usual (TAU) and in Pre-Post-Analyses, MBI show promising results in reducing the, in regards to pharmacotherapy, difficult to treat negative (g = 0.56 and g = 0.75) and positive symptoms (g = 0.19 and g = 0.32) with effect sizes between small and large. In addition, MBI can lead to positive effects on depressive and anxiety symptoms (g = 0.20 and g = 0.43) and contribute to a long-term reduction in re-hospitalization rates 12 months post-discharge and a shortening of the duration of inpatient treatment. In contrast to psychotherapy research from the UK, Australia, and Hong Kong, the scientific evaluation and implementation of mindfulness-based treatment options in the entire German-speaking area are still in the early stages.
Lmx1a-Dependent Activation of miR-204/211 Controls the Timing of Nurr1-Mediated Dopaminergic Differentiation

The development of midbrain dopaminergic (DA) neurons requires a fine temporal and spatial regulation of a very specific gene expression program. Here, we report that during mouse brain development, the microRNA (miR-) 204/211 is present at a high level in a subset of DA precursors expressing the transcription factor Lmx1a, an early determinant for DA-commitment, but not in more mature neurons expressing Th or Pitx3. By combining different in vitro model systems of DA differentiation, we show that the levels of Lmx1a influence the expression of miR-204/211. Using published transcriptomic data, we found a significant enrichment of miR-204/211 target genes in midbrain dopaminergic neurons where Lmx1a was selectively deleted at embryonic stages. We further demonstrated that miR-204/211 controls the timing of the DA differentiation by directly downregulating the expression of Nurr1, a late DA differentiation master gene. Thus, our data indicate the Lmx1a-miR-204/211-Nurr1 axis as a key component in the cascade of events that ultimately lead to mature midbrain dopaminergic neurons differentiation and point to miR-204/211 as the molecular switch regulating the timing of Nurr1 expression.
A Comparative Study of the Safety and Efficacy of Intrapleural Fibrinolysis With Streptokinase and Urokinase in the Management of Loculated Pleural Effusions

Background Intrapleural fibrinolytic therapy (IPFT) with streptokinase (STK), urokinase (UK), and alteplase remains a common practice for managing loculated pleural effusions (LPEs). However, very limited data are available on the comparative efficacy of these agents. Methodology We compared the efficacy and safety of intrapleural streptokinase (n = 28) and urokinase (n = 38) in 66 patients with loculated effusions. IPFT was initiated if effusion remained undrained despite the placement of intercostal chest drainage or pigtail catheter. The dose of STK and UK were 250,000 IU twice daily and 100,000 IU once daily, respectively. The volume of fluid drained after IPFT, radiologic response, clinical response, and adverse events were compared between the two groups. Results The mean volume of fluid drained post-IPFT was 1,379 mL in the STK arm and 1,110 mL in the UK arm (p = 0.251). Of the 66 patients, 53 (80.3%) had good clinical response, and 28 (43.7%) had >75% resolution of effusion on chest radiographs. The clinical (79% vs. 82%; p = 0.765) and radiologic response rates (39.3% vs. 44.6%; p = 0.568) were similar in both STK and UK arms. Pain was the most common adverse event in both groups. Significantly more patients in the STK arm developed fever (14% vs. 0%, p = 0.030). Treatment-limiting adverse events occurred in five patients. Conclusions IPFT is a safe and effective method for managing patients with LPEs. Although the clinical and radiologic response rates were similar with STK and UK, the latter may be the preferred choice because of its better safety profile and ease of administration (once-daily dose).
Output Reachable Set Synthesis of Event-Triggered Control for Singular Markov Jump Systems Under Multiple Cyber-Attacks

This paper investigates the asynchronous event-triggered state-feedback control for discrete-time nonlinear singular Markov jump systems subject to reachable set bounding and stochastic cyber-attacks. An event-triggered mechanism is introduced to regulate data transmission and save network resources. While this mechanism brings advantages, it also causes that the mode information of the system and the controller are not synchronized. On the other hand, network communication has brought convenience to signal transmission, and it has also resulted in the network channel being in an open and unreliable environment, which is vulnerable to cyber-attacks. In order to solve these problems, the secure asynchronous controller is designed to effectively resist the influence of attacks. In addition, by using the reachable set analysis approach, the constructed controller ensures that the estimation error is within the boundary of the ellipsoid, and the existence conditions of the required controller are given by solving the linear matrix inequalities. Finally, a simulation example is given to illustrate the effectiveness of the theoretical results.
Is Tempranillo Blanco Grapevine Different from Tempranillo Tinto Only in the Color of the Grapes? An Updated Review

Tempranillo Blanco is a somatic variant of Tempranillo Tinto that appeared as a natural, spontaneous mutation in 1988 in a single shoot of a single plant in an old vineyard. It was vegetatively propagated, and currently wines from Tempranillo Blanco are commercially available. The mutation that originated Tempranillo Blanco comprised single-nucleotide variations, chromosomal deletions, and reorganizations, losing hundreds of genes and putatively affecting the functioning and regulation of many others. The most evident, visual change in Tempranillo Blanco is the anthocyanin lost, producing this grapevine variety bunches of colorless grapes. This review aims to summarize from the available literature differences found between Tempranillo Blanco and Tinto in addition to the color of the grapes, in a climate change context and using fruit-bearing cuttings grown in temperature-gradient greenhouses as research-oriented greenhouses. The differences found include changes in growth, water use, bunch mass, grape quality (both technological and phenolic maturity), and some aspects of their photosynthetic response when grown in an atmosphere of elevated CO2 concentration and temperature, and low water availability. Under field conditions, Tempranillo Blanco yields less than Tempranillo Tinto, the lower weight of their bunches being related to a lower pollen viability and berry and seed setting.
Teachers’ self-efficacy and role when teaching STEM in high-tech informal learning environments

Background: Informal learning environments (ILEs) like Fablabs and Makerspaces have potential to facilitate development of STEM skills. However, these environments might be difficult for teachers to adopt in their teaching because of teaching approaches grounded in constructionism where the role of the teacher changes from a transmissive instructor to an active co-creator, and using high-tech equipment not normally found in schools. Purpose: The aim is to investigate teachers’ self-efficacy and perceived role when teaching STEM in Fablabs and Makerspaces. This is investigated related to teaching in ILEs and using high-tech equipment. The study was conducted in two countries/regions, Flanders (Belgium) and Sweden We also compare differences between teachers depending on nationality, gender, and years of teaching experience. Sample: A total of 347 secondary school teachers completed an online survey. Quantitative analyses was used for all questions in the survey, except one open-ended question, which was analysed through inductive thematic coding. Results: The teachers reported moderate self-efficacy for teaching in ILEs , and low self-efficacy for using high-tech equipment. Some teachers described themselves as having active roles as a coach or as co-learner during visits with their students. Others saw themselves as having a passive role. Many teachers did not know what kind of role to take. The teachers who perceived an active role as a teacher in high-tech ILEsreported higher self-efficacy to teach in these environments than other teachers.
Efficacy and Safety of Semaglutide for the Management of Obese Patients With Type 2 Diabetes and Chronic Heart Failure in Real-World Clinical Practice

Background The impact of glucagon-like peptide-1 receptor agonists on patients with heart failure has not been fully described. Our main objective was to evaluate the safety and clinical and glycemic efficacy of once-weekly semaglutide in obese patients with type 2 diabetes and heart failure. Methods In this observational, retrospective, real-world study, we enrolled outpatients with type 2 diabetes, obesity, and heart failure who started semaglutide and were followed-up on at 3, 6, and 12 months. Results A total of 136 patients were included. From baseline to 12 months, there was a significant improvement on the Kansas City Cardiomyopathy Questionnaire total symptom score (59.0 ± 24.1 vs 79.9 ± 28.4 points, p<0.01), a reduction in the proportion of patients with New York Heart Association functional class III (40.4% to 16.2%, p<0.01), and a reduction in N-terminal pro-brain natriuretic peptide levels (969.5 ± 653.5 vs 577.4 ± 322.1 pg/mL, p<0.01). Emergency department visits due to heart failure, hospitalizations due to heart failure, and all-cause hospitalizations also declined. Additionally, significant reductions in glycated hemoglobin (-1.4%) and body weight (-12.7 kilograms) were observed as well as a de-intensification of antidiabetic therapy. Moreover, semaglutide was safe and well-tolerated. Conclusion In obese patients with type 2 diabetes and heart failure, the use of once-weekly semaglutide was safe and clinically efficacious, improving health and functional status. Nevertheless, more strong evidence on glucagon-like peptide-1 receptor agonists in heart failure is required.
Learners’ Experiences of Mobile Learning in Vocational and Technical Education Courses

Background: Since mobile learning is emerging as an alternative approach to teaching, educational institutions have used this approach to improve the teaching and learning process. This paper aimed at exploring learners’ experiences of mobile learning in vocational and technical education courses. Methods: The research method in this study was phenomenology. In this method, researchers investigated learners’ lived experi-encesofmobilelearninginvocationalandtechnicaleducationcoursesbysemi-structuredinterviews. Participants(twoclassrooms: 32 people) were all learners, who attended this course. Results: Accordingtothemeanalysisofinterviews,ninebasicthemeswereidentiﬁed,twoorganizingthemesandoneglobaltheme. Based on thematic analysis, the results showed that learners had a positive perception of mobile learning. Conclusions: Using mobile learning, learners gain greater quality and in-depth learning and the opportunity to study anywhere and at any time.
Fluid Approximations for Revenue Management Under High-Variance Demand

One of the most prevalent demand models in the revenue management literature is based on dividing the selling horizon into a number of time periods such that there is at most one customer arrival at each time period. This demand model is equivalent to using a discrete-time approximation to a Poisson process, but it has an important shortcoming. If the mean number of customer arrivals is large, then the coefficient of variation of the number of customer arrivals has to be small. In other words, large demand volume and large demand variability cannot coexist in this demand model. In this paper, we start with a revenue management model that incorporates general mean and variance for the number of customer arrivals. This revenue management model has a random selling horizon length, capturing the distribution of the number of customer arrivals. The question we seek to answer is the form of the fluid approximation that corresponds to this revenue management model. It is tempting to construct the fluid approximation by computing the expected consumption of the resource capacities in the constraints and the total expected revenue in the objective function through the distribution of the number of customer arrivals. We demonstrate that this answer is wrong in the sense that it yields a fluid approximation that is not asymptotically tight as the resource capacities get large. We give an alternative fluid approximation where perhaps surprisingly, the distribution of the number of customer arrivals does not play any role in the constraints. We show that this fluid approximation is asymptotically tight as the resource capacities get large. A numerical study also demonstrates that the policies driven by the latter fluid approximation perform substantially better, so there is practical value in getting the fluid approximation right under high-variance demand. This paper was accepted by Omar Besbes, revenue management and market analytics. Funding: The work of the O. El Housni and H. Topaloglu was supported by a seed grant from Urban Tech research hub at Cornell Tech. Supplemental Material: The data files and online appendix are available at https://doi.org/10.1287/mnsc.2023. 4769 .
Computer-Aided Multi-Epitope Vaccine Design against Enterobacter xiangfangensis

Antibiotic resistance is a global public health threat and is associated with high mortality due to antibiotics’ inability to treat bacterial infections. Enterobacter xiangfangensis is an emerging antibiotic-resistant bacterial pathogen from the Enterobacter genus and has the ability to acquire resistance to multiple antibiotic classes. Currently, there is no effective vaccine against Enterobacter species. In this study, a chimeric vaccine is designed comprising different epitopes screened from E. xiangfangensis proteomes using immunoinformatic and bioinformatic approaches. In the first phase, six fully sequenced proteomes were investigated by bacterial pan-genome analysis, which revealed that the pathogen consists of 21,996 core proteins, 3785 non-redundant proteins and 18,211 redundant proteins. The non-redundant proteins were considered for the vaccine target prioritization phase where different vaccine filters were applied. By doing so, two proteins; ferrichrome porin (FhuA) and peptidoglycan-associated lipoprotein (Pal) were shortlisted for epitope prediction. Based on properties of antigenicity, allergenicity, water solubility and DRB*0101 binding ability, three epitopes (GPAPTIAAKR, ATKTDTPIEK and RNNGTTAEI) were used in multi-epitope vaccine designing. The designed vaccine construct was analyzed in a docking study with immune cell receptors, which predicted the vaccine’s proper binding with said receptors. Molecular dynamics analysis revealed that the vaccine demonstrated stable binding dynamics, and binding free energy calculations further validated the docking results. In conclusion, these in silico results may help experimentalists in developing a vaccine against E. xiangfangensis in specific and Enterobacter in general.
An Observational Study of Cutaneous Manifestations in Internal Malignancy at Tertiary Care Centre

Introduction: Skin is the largest organ in the human body and mirrors the changes in the organism it envelops. Internal malignancies can cause various specific and non-specific cutaneous manifestations along with hair, nail and oral mucosal changes. Some of the changes are detected early indicating a strong association with cancer, while some occur in later stage indicating dissemination or immunosuppression. The present study is an effort to know pattern of dermatosis associated with internal malignancies so that early diagnosis and interventions can be done. Aim: To determine the pattern of specific and non-specific dermatosis associated with internal malignancy. Methods and Material: Patients of internal malignancies with skin lesions attending dermatology and oncology department during July 2020 to June 2021 were recruited in the study after taking written informed consent. A detailed history of skin lesions and malignancies were taken. Clinical examination (skin/hair/nail) was carried out and photographs were taken. Relevant investigations were carried out. Frequency and percentage of dermographic data and dermatosis associated with internal malignancies were calculated. Results: The study included 150 patients with maximum number of patients 78 (52%) in 41-60 years of age group with female: male ratio of 1.2:1. Most common internal malignancy was breast carcinoma in 43 (28.67%) cases. Specific dermatosis were seen in 5 (3.33%) cases and non-specific dermatosis in 121 (80.66%) cases. Specific dermatosis were vasculitis, necrolytic migratory erythema, lymphocytoma cutis, growth and cutaneous metastasis with 1 (0.67%) patient each. Most common non-specific dermatosis was herpes zoster in 17 (11.33%) cases. Conclusion: The study was useful in understanding the various specific and non specific dermatosis associated with internal malignancies and thereby helping the physician to manage the conditions.
History and Place in Television Drama: Liverpool in Cilla and Boys From the Blackstuff

This article explores historical representations of Liverpool in two television dramas: ITV’s Cilla (2014) and the BBC’s Boys from the Blackstuff (1982). It is concerned with the ways that television drama can both record and recreate places from the past. Focussing on two dramas set in Liverpool at formative moments in the city’s past, it considers the centrality of an evocation of place and specifically the space of the city to both series and the ways that television dramas that mobilise such a strong sense place can become intrinsic to the heritage and history of the places they depict.
Palynomorphological and taxonomical investigations of some Apiaceae taxa from Bilecik, Turkey

Abstract The objective of the present study is to investigate pollen morphology and taxonomy of some Apiaceae species in Bilecik, Turkey. The study area is restricted to Vezirhan in the south (Bilecik), Pamukova and Geyve in the north (Sakarya), İznik in the west (Bursa), Gölpazarı in the south-east (Bilecik) and Taraklı in the east (Sakarya). Apiaceae species were collected from the study area by visiting there in all four seasons. In this study, the pollen morphology of 22 taxa belonging to different genera of the Apiaceae family was investigated for the first time in detail using light microscope and scanning electron microscopy (SEM). The pollen is radially symmetrical, isopolar and tricolporate in all examined species. Pollen grains are perprolate, prolate and subprolate with the polar axis ranging from 17.53 µm (Non-acetolysed: N) and 18.28 µm (Acetolysed: A) to 39.71 µm (N) and 39.72 µm (A) and the equatorial axis from 11.77 µm (N) and 12.2 µm (A) to 23.77 µm (N) and 23.54 µm (A). The polar shapes of the studied taxa are triangular. Exine ornamentations of four pollen types have been observed by SEM. Two main groups were revealed in the dendrogram which was constructed by using Average Linkage from the examined data. It was determined that some pollen characteristics of investigated Apiaceae taxa are supporters of the classification of taxa with other taxonomical characteristics. Also, three components of investigated palynological characteristics were identified with principal component analysis. Polar axis (P), equatorial axis (E), the ratio of polar axis to equatorial axis (P/E) (pollen shape) and ornamentation in the polar and equatorial views are determined as the most important palynological characteristics for discrimination of the Apiaceae taxa.
Disclosure avoidance practices and research at the U.S. Census Bureau: an update

The U.S. Census Bureau collects its survey and census data under Title 13 of the U.S. Code which promises confidentiality to its respondents. The agency also has the responsibility of releasing data for the purpose of statistical analysis. In common with most national statistical institutes, our goal is to release as much high quality data as possible without violating the pledge of confidentiality. We apply disclosure avoidance techniques prior to publicly releasing our data products to protect the confidentiality of our respondents and their data (Willenborg and de Waal 2001). This article discusses the various types of data we release, our disclosure review process, restricted access procedures, disclosure avoidance techniques currently being used, and current disclosure avoidance research.