Miracle-dz/UniFAR-FTUs huggingface dataset:
Clinicopathological Features and Prognostic Implication of Gastric Carcinoma with Lymphoid Stroma

Methods This study included 34 eligible studies and 1757 GCLSs. The clinicopathologic characteristics of GCLS were investigated from eligible studies, and the meta-analysis was performed. In addition, we compared the survival rates between GCLS and non-GCLS. Results The estimated rate of GCLS was 0.062 (95% confidence interval (CI) 0.040-0.097). GCLS was significantly correlated with the diffuse type of Lauren's classification, proximal tumor location, less-frequent lymphatic invasion, and lower pTNM stage. However, there was no significant difference in age, sex, tumor differentiation, vascular invasion, perineural invasion, pT stage, lymph node metastasis, and distant metastasis between GCLS and non-GCLS patients. EBV positive rates in GCLS and non-GCLS patients were 0.723 (95% CI 0.643-0.791) and 0.064 (95% CI 0.039-0.103), respectively. HER2 expression in GCLS was significantly lower than that in non-GCLS. GCLS patients had a more favorable prognosis than that of non-GCLS patients (hazard ratio 0.500, 95% CI 0.305-0.821). Conclusion GCLS comprised 6.2% of overall GC and more frequent in the proximal portion of the stomach. Since GCLS was associated with better prognosis, the histologic finding can be useful for predicting the patient's prognosis.
Sec‐Eliminating the SARS‐CoV‐2 by AlGaN Based High Power Deep Ultraviolet Light Source

The world‐wide spreading of coronavirus disease (COVID‐19) has greatly shaken human society, thus effective and fast‐speed methods of non‐daily‐life‐disturbance sterilization have become extremely significant. In this work, by fully benefitting from high‐quality AlN template (with threading dislocation density as low as ≈6×108 cm−2) as well as outstanding deep ultraviolet (UVC‐less than 280 nm) light‐emitting diodes (LEDs) structure design and epitaxy optimization, high power UVC LEDs and ultra‐high‐power sterilization irradiation source are achieved. Moreover, for the first time, a result in which a fast and complete elimination of SARS‐CoV‐2 (the virus causes COVID‐19) within only 1 s is achieved by the nearly whole industry‐chain‐covered product. These results advance the promising potential in UVC‐LED disinfection particularly in the shadow of COVID‐19.
Longitudinal sampling is required to maximize detection of intrahost A/H3N2 virus variants

Abstract Seasonal human influenza viruses continually change antigenically to escape from neutralizing antibodies. It remains unclear how genetic variation in the intrahost virus population and selection at the level of individual hosts translates to the fast-paced evolution observed at the global level because emerging intrahost antigenic variants are rarely detected. We tracked intrahost variants in the hemagglutinin and neuraminidase surface proteins using longitudinally collected samples from 52 patients infected by A/H3N2 influenza virus, mostly young children, who received oseltamivir treatment. We identified emerging putative antigenic variants and oseltamivir-resistant variants, most of which remained detectable in samples collected at subsequent days, and identified variants that emerged intrahost immediately prior to increases in global rates. In contrast to most putative antigenic variants, oseltamivir-resistant variants rapidly increased to high frequencies in the virus population. Importantly, the majority of putative antigenic variants and oseltamivir-resistant variants were first detectable four or more days after onset of symptoms or start of treatment, respectively. Our observations demonstrate that de novo variants emerge, and may be positively selected, during the course of infection. Additionally, based on the 4–7 days post-treatment delay in emergence of oseltamivir-resistant variants in six out of the eight individuals with such variants, we find that limiting sample collection for routine surveillance and diagnostic testing to early timepoints after onset of symptoms can potentially preclude detection of emerging, positively selected variants.
Single molecule photodynamics by means of one- and two-photon approach

Single molecule spectroscopy allows to investigate heterogeneous behaviours on photochemical and structural grounds. We report on studies of the effect of the excitation intensity on the internal photodynamics of simple dyes immobilized on chemically etched glass slides. The use of the excitation intensity needed for two-photon excitation induces local heating, structural changes and transitions to dark states. Similar behaviour is found on single green fluorescent proteins immobilized on glass slides or embedded in silica gels upon single-photon excitation. However, by sampling the images with sufficiently low frequency, we are able to follow relevant biological events, such as the unfolding kinetics. We find that the glass slides are preferable in terms of the signal-to-noise ratio but the protein is not preserved in its native state, while evidence for the native conformation of the single proteins in the silica gels is found in the uniformity of the fluorescence emission.
STABILITY OF FOLIAR NITROGEN:SULFUR RATIO IN SPRING RED WHEAT AND SULFUR DILUTION CURVE

A key aspect of any sulfur (S) availability indicator is its stability throughout the crop cycle. Nine experiments were conducted with the objective to evaluate the stability of the nitrogen (N):S ratio in aerial biomass (W) in spring wheat, and to define the critical curve of S dilution. As the crop cycle progressed, a decrease (P < 0.05) in total N:S was determined. This lack of stability was explained by a lower S dilution in relation to N (P < 0.05). A decrease (P < 0.05) in N accumulation rate in relation to S was obtained as the crop cycle progressed, which points out that S accumulation in relation to N is later. A first approach was determined to the definition of the S dilution critical curve (Sc) from tillering beginning to stem elongation end (Sc = 0.37 W−0.169; r2 = 0.71 and n = 24).
Band offsets of wide-band-gap oxides and implications for future electronic devices

Wide-band-gap oxides such as SrTiO3 are shown to be critical tests of theories of Schottky barrier heights based on metal-induced gap states and charge neutrality levels. This theory is reviewed and used to calculate the Schottky barrier heights and band offsets for many important high dielectric constant oxides on Pt and Si. Good agreement with experiment is found for barrier heights. The band offsets for electrons on Si are found to be small for many key oxides such as SrTiO3 and Ta2O5 which limit their utility as gate oxides in future silicon field effect transistors. The calculations are extended to screen other proposed oxides such as BaZrO3. ZrO2, HfO2, La2O3, Y2O3, HfSiO4, and ZrSiO4. Predictions are also given for barrier heights of the ferroelectric oxides Pb1−xZrxTiO3 and SrBi2Ta2O9 which are used in nonvolatile memories.
Highly Robust Lithium Ion Battery Anodes from Lignin: An Abundant, Renewable, and Low‐Cost Material

The synthesis, processing, and performance of a low‐cost monolithic battery electrode, produced entirely of natural and renewable resources, are reported. This anode material exhibits tunable electrochemical performance suitable for both high power and high energy applications. A synthesis method that directly results in electrically interconnected three‐dimensional architectures is presented, where the carbon framework functions as current collector and lithium insertion material, eliminating the extra mass and expense of inactive materials in conventional designs. Fibrous carbon electrode materials are produced from solvent extracted lignin using scalable melt processing technology and thermal conversion methods. The resulting free‐standing electrodes exhibit comparable electrochemical performance to commercial carbon‐based anodes at a fraction of the materials and processing costs. Compositional and electrochemical characterization shows that carbonized lignin has a disordered nano‐crystalline microstructure. The carbonized mats cycle reversibly in conventional aprotic organic electrolytes with Coulombic efficiencies over 99.9%. Moreover, lignin carbon fibers carbonized at 2000 °C can cycle reversibly in 1 m LiPF6 in propylene carbonate.
Three dimensional reciprocal space measurement by x-ray diffraction using linear and area detectors: Applications to texture and defects determination in oriented thin films and nanoprecipitates

The authors present a method for the fast and efficient measurement of volumes of reciprocal space by x-ray diffraction using linear and area detectors. The goal of this technique is to obtain a complete overview of the reciprocal space to detect and characterize the nature and orientation of all the phases present. They first explain the detailed procedures and scan strategies required for transforming raw scattering data into three-dimensional maps of reciprocal space and present a complete open-source software package for advanced data processing, analysis, and visualization. Several case studies, chosen to highlight the overall capabilities of the technique, are then introduced. First, thermal diffuse scattering from a monocrystalline Si substrate is characterized by the presence of lines linking diffraction peaks in reciprocal space. Second, a detailed investigation of texture in multiphase thin layers permits us to reveal the unambiguous presence of fiber, axiotaxial, and epitaxial components in ori.
Effect of Propylation on the Characteristics of Corn Starch and Variation of Properties with Different Degrees of Substitution

Corn starch was modified by propylation with different degree of substitution (DS). DS of four starch modifications were 0.61, 1.56, 2.27, and 2.51. Samples were characterized by FTIR, XRD, TG-DTA, swelling power, solubility, water binding capacity, and light transmittance. Results of the systematic physico-chemical characterization of the starch modification in comparison with the native starch have been documented in the article. Results showed that during propylation, the crystalline structure of starch got destroyed and surface of the starch was eroded. Propylated starch (DS 2.51) showed 85% weight loss at temperatures from 300 to 400°C, whereas the native starch underwent similar weight loss (83%) from 250 to 300°C. Swelling power and water binding capacity of native starch (DS 0.0) were 3.09 g/g and 89.8%, respectively. However, in propylated starch at low DS (DS 0.61), swelling power and water binding capacity increased to 10.55 g/g and 136.8% under same conditions. At high DS (DS 2.51), swelling power was similar to native starch at 65°C, whereas solubility and water binding capacity decreased to below that of native starch. Light transmittance of propylated starch with high DS (DS 2.51) increased dramatically compared with native starch. Propylation improved the hydrophobic transformation and thermal stability of starch at high DS. © 2010 Wiley Periodicals, Inc. J Appl Polym Sci, 2011
Analysis of User’s Acceptance of The Accrual-Based Financial Simda with Technology Acceptance Model (Tam) 3 Adapted Approach

The purpose of this research is to analyze the user’s acceptance of the Accrual-Based Financial SIMDA by using Technology Acceptance Model 3 adapted approach. The research has 7 variables, namely: Result demonstrability (RES), Computer Playfulness (CPLAY), Perceived Enjoyment (ENJ) , Perceived Usefulness (PU), Perceived Ease of Use (PEOU), Behavioral Intention (BI), and System Usage (USE). This research is a quantitative research held at the Local Government of Brebes. The method of gathering data is survey by distributing questionnaires to the respondents. The research uses proportionate stratified random sampling. A total of 108 questionnaires were distributed in this study, 106 questionnaires could be collected. The result shows that the System Usage (USE) is affected by three variables, namely: Behavioral Intention (BI), Perceived Usefulness (PU) and Perceived Ease of Use (PEOU). Behavioral Intention (BI) is affected by Perceived Usefulness (PU) and Perceived Ease of Use (PEOU). Perceived Usefulness (PU) is affected by Result Demonstrability (RES) and Perceived Ease of Use (PEOU). Meanwhile, Perceived Ease of Use (PEOU) is affected by the Computer Playfulness (CPLAY) and Perceived Enjoyment (ENJ). This research expected to provide a solution to the problems related to user acceptance of the Accrual-Based Financial SIMDA and to increase user acceptance.
Computational Models for Diagnosing Tuberculosis: A Systematic Review

: Introduction: Tuberculosis (TB) is an infectious disease caused by the bacterium Mycobacterium tuberculosis. It kills about 1.5 million people per year and about 95% of its victims are from Africa. A major problem of TB is the difficulty in its diagnosis due to the fact that in most cases, it is either asymptomatic or latent. This difficulty in diagnosis has motivated the development of various algorithms for TB diagnosis most of which have poor diagnosis power. Aim: This research focused on systematic review and analysis of computational models for diagnosis of TB with the view to identifying their strengths and weaknesses. The overall target is to develop a standard and robust computational model with improved diagnostic power. Method: Selection was from peer-reviewed articles on Google scholar assessing strictly computational TB diagnostic models. Search terms include: Diagnosis, Tuberculosis, Computational, Mathematics, Bayes, Soft computing, Fuzzy logic, Neural Network. Exclusions were made based on some criteria. Results: Initial search returned 303 of which only 42 studies met the inclusion criteria. 19 were on neural network or neuro-fuzzy, 2 studies were on Expert System. 7 analysed fuzzy logic/hybrids and Bayesian/data mining appeared in 7 reports. 5 studies were on Genetic Algorithm and its hybridized forms while 2 papers were on other methods. Conclusion : Results suggest that accuracy and speed need to be improved due to weaknesses in existing models. Hybridization of Genetic algorithm, Neuro-fuzzy and Bayesian techniques will most likely guarantee improved diagnosis, however, further quantitative analysis is required to confirm this.
NUTRITIONAL AND ECONOMICAL IMPACT OF USING SUPER STARTER DIETS IN FEEDING BROILER CHICKENS

n experiment was conducted to study the effect of feeding recommended (23%, Diet1) or high (25%, super starter, Diet2) crude protein in starter diets on productive performance, carcass characteristics and economicalefficiency of Hubbard broiler chickens. A total of 225, day old Hubbard broiler male chicks were randomly distributed into 5 treatments at (1-35) days of age, each with three replicates of 15 birds each. The five treatments were: T1) Control group, chicks fed (Diet1) ad-libitum the other treatments from T2 till T5, chicks were fed (Diet2)at different quantities being 125g, 250g, 375g and 500g/chick, respectively followed by (Diet1) to the end of starter period (14 days of age). During grower and finisher periods, all chicks were fed recommended diets at these phases. At the end of experiment at 35 days of age, 4 broilers chicken per treatment were slaughtered and evaluated for carcass traits. The results indicate that: Body weight, body weight gain and feed intake were linearly increased, whereas feed conversion ratio decreased as super starter diet increased, during overall period (1-35 days of age). The best values of body weight gain, feed conversion ratio, protein and energy conversion ratio were observed for chickens fed 500g super starter diet compared with other dietary treatments. In most cases differences between treatments were significant (P≤0.01). Carcass characteristics of chicks fed super starter diet, added at different levels had no effects on carcass characteristics. The best economical efficiency value were demonstrated when broiler chickens fed (500g Diet2/chick) super starter diet and the values was 33.09% more when compared to that of chicks fed control diets. In conclusion, feeding broiler chickens super starter diet at level of (500g/chick) support and enhance productive performance and economical efficiency.
Detection of Hepatitis B surface Antibodies (Anti-Hbs), Lifelong Immunity to HBV in HIV positive Patients in Ojo, Lagos, Nigeria

: Introduction: Detection of Hepatitis B surface antibodies (anti-HBs) in the serum implies that an individual is immune to HBV infection either from vaccination or past infection, which usually persists for life. Aims: This study aimed to determine the seropositivity of anti-HBs among HIV-seropositive patients, and further appraise the effect of co-infection on their immunological status in Ojo, Lagos, Nigeria. Materials and Methods: A total of 74 blood samples collected from HIV positive patients were analysed for anti-HBs (HBsAb) by Immunochromatographic assay (Biotec, UK). CD4+ count was determined using BD FACS Count Automated analyser. Results: Out of the 74 HIV infected patients screened, 12 (16.2 %) males and 62 (83.8 %) females, 2 patients (2.7 %) were positive for anti-HBs, with no prevalence among the males and 2.7 % among the females. Anti-HBs was only recorded in HIV positive patients in the 21-30 years age group (8.7 %). The result showed anti-HBs lifelong protection to HBV among HIV patients with CD4+ Count ranging from 601-700 and 901-1000 to be 1.7 % and 1.7 % respectively. Protection of 3.5 % was reported among antiretroviral therapy (ART) naïve patients and 0 % protection among ART patients. Conclusion: Our findings showed prevalence of 2.7% HBsAb in the studied HIV positive patients with a protection of 3.5 % anti-HBs to HBV among antiretroviral therapy (ART) naïve patients in Ojo, Lagos. The low prevalence of HBsAb in HIV positive patients may be attributed to suppression of immune responses leading to the loss of previously developed protective antibody against HBV infection. We hereby suggest anti-HBs screening for all HIV positive patients and that those negative should be vaccinated to help them develop protective immunity to HBV infection. To
Connexin 43 K63-polyubiquitination on lysines 264 and 303 regulates gap junction internalization

Gap junctions (GJs) assembled from connexin (Cx) proteins play a pivotal role in cell-to-cell communication by forming channels that connect the cytosols of adjacent cells. Connexin 43, the best-studied Cx, is ubiquitously expressed in vertebrates. While phosphorylation is known to regulate multiple aspects of GJ function, much less is known about the role ubiquitination plays in these processes. Here we show by using ubiquitination-type specific antibodies and Cx43 lysine (K) to arginine (R) mutants that a portion of Cx43 in GJs can become K63-polyubiquitinated on K264 and K303. Relevant Cx43 K/R mutants assembled significantly larger GJ plaques, exhibited much longer protein half-lives and were internalization impaired. Interestingly, ubiquitin-deficient Cx43 mutants accumulated as hyper-phosphorylated polypeptides in the plasma membrane, suggesting that K63-polyubiquitination may be triggered by phosphorylation. Phospho-specific Cx43 antibodies revealed that upregulated phosphorylation affected serines 368, 279/282, and 255, well-known regulatory PKC and MAPK phosphorylation sites. Together, these novel findings suggest that upon internalization, some Cx43 in GJs becomes K63-polyubiquitinated, ubiquitination is critical for GJ internalization, and that K63-polyubiquitination may be induced by Cx phosphorylation. Summary Statement Here we show that connexin 43 in gap junctions becomes K63-poly ubiquitinated on lysines 264 and 303 and its requirement for gap junction endocytosis. These novel findings significantly contribute to our understanding of GJ turnover and patho-/physiology. Abbreviations used AGJ annular gap junction AMSH associated molecule with the SH3 domain of STAM CME clathrin-mediated endocytosis Cx Connexin Cx43 Connexin 43 DUB deubiquitinase GJ gap junction MonoUb monoubiquitin Nedd4-1 neural precursor cell expressed developmentally down-regulated protein 4-1 PM plasma membrane PolyUb polyubiquitin TPA 12-O-Tetradecanoylphorbol 13-Acetate TX-100 Triton X-100 RT room temperature Ub ubiquitin
Adverse Childhood Experiences and Justice System Contact: A Systematic Review

In this systematic review, we synthesize epidemiological evidence for the association between ACEs and later justice system contact. BrightcoveDefaultPlayer10.1542/6204172920001PEDS-VA_2020-021030 Video Abstract CONTEXT: Given the wide-ranging health impacts of justice system involvement, we examined evidence for the association between adverse childhood experiences (ACEs) and justice system contact in the United States. OBJECTIVE: To synthesize epidemiological evidence for the association between ACEs and justice system contact. DATA SOURCES: We searched 5 databases for studies conducted through January 2020. The search term used for each database was as follows: (“aces” OR “childhood adversities”) AND (“delinquency” OR “crime” OR “juvenile” OR criminal* OR offend*). STUDY SELECTION: We included all observational studies assessing the association between ACEs and justice system contact conducted in the United States. DATA EXTRACTION: Data extracted from each eligible study included information about the study design, study population, sample size, exposure and outcome measures, and key findings. Study quality was assessed by using the Newcastle-Ottawa Scale for nonrandomized trials. RESULTS: In total, 10 of 11 studies reviewed were conducted in juvenile population groups. Elevated ACE scores were associated with increased risk of juvenile justice system contact. Estimates of the adjusted odds ratio of justice system contact per 1-point increase in ACE score ranged from 0.91 to 1.68. Results were consistent across multiple types of justice system contact and across geographic regions. LIMITATIONS: Most studies reviewed were conducted in juvenile justice-involved populations with follow-up limited to adolescence or early adulthood. CONCLUSIONS: ACEs are positively associated with juvenile justice system contact in a dose-response fashion. ACE prevention programs may help reduce juvenile justice system contacts and improve child and adolescent health.
Heart Rate Variability-Measured Stress and Academic Achievement in Medical Students

Objectives: Stress can affect learning and memory in students. Previous studies on stress in students were conducted mainly through surveys. We investigated how heart rate variability (HRV)-measured stress is related to academic achievement in medical students during clerkship. Subjects and Methods: A cross-sectional study was conducted. HRV measurements were performed in 97 third-year medical students during their family medicine clerkship course. Data on written and skilled examination scores of the end of the school year were also collected. We assessed the association between HRV-measured stress and written/skilled examination scores. Results: Written examination scores showed a positive correlation with standard deviation of the normal-to-normal intervals (SDNNs) (r = 0.245, p = −0.016), sympathetic nervous system/parasympathetic nervous system (SNS/PNS) balance (r = 0.218, p = 0.033), and stress index (r = 0.381, p = 0.004). Students with an unhealthy SDNN, a dominant SNS, and a high stress index had higher scores in written examinations than students with a healthy SDNN, a balanced SNS/PNS, and a normal stress index, respectively (p = 0.004, 0.018, and 0.012, respectively). Moreover, skilled examination scores were negatively correlated with BMI (r = −0.249, p = 0.014) and were higher in female students (r = 0.240, p = 0.018). Students with an abnormal autonomic balance diagram (ABD) had a higher score than students with a normal ABD (p = 0.03). Conclusions: This study shows that medical students with higher stress measured by HRV have higher academic achievement, especially in written examinations. Further studies are needed to confirm the results of this study and to assess the long-term effects of HRV-measured stress on medical students.