Miracle-dz/UniFAR-FTUs huggingface dataset:
Nationwide use and Outcome of Minimally Invasive Distal Pancreatectomy in IDEAL Stage IV following a Training Program and Randomized Trial

Objective: To assess the nationwide long-term uptake and outcomes of minimally invasive distal pancreatectomy (MIDP) after a nationwide training program and randomized trial. Background: Two randomized trials demonstrated the superiority of MIDP over open distal pancreatectomy (ODP) in terms of functional recovery and hospital stay. Data on implementation of MIDP on a nationwide level are lacking. Methods: Nationwide audit-based study including consecutive patients after MIDP and ODP in 16 centers in the Dutch Pancreatic Cancer Audit (2014 to 2021). The cohort was divided into three periods: early implementation, during the LEOPARD randomized trial, and late implementation. Primary endpoints were MIDP implementation rate and textbook outcome. Results: Overall, 1496 patients were included with 848 MIDP (56.5%) and 648 ODP (43.5%). From the early to the late implementation period, the use of MIDP increased from 48.6% to 63.0% and of robotic MIDP from 5.5% to 29.7% (P<0.001). The overall use of MIDP (45% to 75%) and robotic MIDP (1% to 84%) varied widely between centers (P<0.001). In the late implementation period, 5/16 centers performed >75% of procedures as MIDP. After MIDP, in-hospital mortality and textbook outcome remained stable over time. In the late implementation period, ODP was more often performed in ASA score III-IV (24.9% vs. 35.7%, P=0.001), pancreatic cancer (24.2% vs. 45.9%, P<0.001), vascular involvement (4.6% vs. 21.9%, P<0.001), and multivisceral involvement (10.5% vs. 25.3%, P<0.001). After MIDP, shorter hospital stay (median 7 vs. 8 d, P<0.001) and less blood loss (median 150 vs. 500 mL, P<0.001), but more grade B/C postoperative pancreatic fistula (24.4% vs. 17.2%, P=0.008) occurred as compared to ODP. Conclusion: A sustained nationwide implementation of MIDP after a successful training program and randomized trial was obtained with satisfactory outcomes. Future studies should assess the considerable variation in the use of MIDP between centers and, especially, robotic MIDP.
Sanitation-hygiene Knowledge, Practices and Human Health Impacts: Insights from Coastal Bangladesh

Better sanitation and hygiene are very significant for sound health for human lives and it protects various water borne disease. This study aims to find sanitation-hygiene knowledge, practices and impacts on human health of coastal Bangladesh. Rajoir (Sarankhola), Gangarampur (Batiaghata) and Ganapatipur (Kalaroa) villages are purposively designated from shoreline, interim and inland coast. Data are collected with semi-structured questionnaire between July-October 2022 and analyzed through SPSS and map is produced with Arc GIS. Overall about 9.6, 36.3 and 54.1% respondents have good, moderate and poor knowledge regarding sanitation and hygiene. Overall about 57% respondents have accessed sanitary latrines. About 67% respondents claimed that their children deface are thrown in the toilet, followed by, around the house (16%). About 70, 83 and 84% respondents wash their hands with soap/handwash after defecation in shoreline, interim and inland area, followed by, 34, 35 and 27% before taking meal; 19, 19 and 4% before cooking; 9, 21 and 16% after household chores. Cleanliness index are categorized into satisfactory levels except water containers for shoreline (0.677) and inland (0.718) areas. About 96% (shoreline), 91% (interim) and 95% (inland) respondents claim women play a direct role during collection of water. Based on sanitation inspection tool, overall 6, 41, 47 and 3% tube-wells are grouped into very high, high, intermediate and low risk categories. About 57% (shoreline), 48% (interim) and 36% (inland) water sources are grouped into ‘high’s category. The study suggest to formate management committee to monitor proper sanitation and hygiene systems. Keywords : Coastal area; human health; cleanliness; sanitary inspection tool Copyright (c) 2023 Geosfera Indonesia and Department of Geography Education, University of Jember This work is licensed under a Creative Commons Attribution-Share A like 4.0 International License
Study Of Workload And Employee Competence Towards Employee Performance With Organizational Commitment As An Intervening Variable

Employee performance that is not as expected has an impact on the overall performance of the organization, so the focus of this study is to examine the influence of workload, competence on employee performance through organizational commitment studies on employees of PT Hitachi Metals Indonesia Cilegon with a total sample of 100 employees in the Quality Control Division, the data collection technique used is the distribution of questionnaires with a Likert scale as a rating scale, In this study, the hypothesis is tested using path analysis with SPSS and the Sobel Test, and the results show that workload has a positive effect on commitment and performance, and competence has a positive effect on employee commitment and performance. While organizational commitment can mediate between workload and performance, as well as competence and performance.
Combined Biologic Augmentation Strategies with Collagen Patch Graft, Microfractures, and Platelet Concentrate Injections Improve Functional and Structural Outcomes of Arthroscopic Revision Rotator Cuff Repair

Background: Arthroscopic revision rotator cuff repair (ARRCR) is challenging. Biologic strategies seem to be promising. The aim was to evaluate the effectiveness of the combination of microfractures of the greater tuberosity, augmentation with collagen patch graft, and platelet concentrate injections in ARRCR. Methods: A retrospective comparative study was conducted on patients that underwent ARRCR with a minimum follow-up of two years. Patients in the augmentation group underwent ARRCR combined with microfractures, collagen patch graft, and postoperative subacromial injections of platelet concentrate. A standard rotator cuff repair was performed in the control group. Primary outcome: Constant-Murley score (CMS). Secondary outcomes: disease-specific, health-related quality of life using the Disabilities of the Arm, Shoulder, and Hand (DASH) score; assessment of tendon integrity with magnetic resonance at least six months after surgery. Significance was set at p < 0.05. Results: Forty patients were included. Mean follow-up was 36.2 ± 8.7 months. The mean CMS was greater in the augmentation group (p = 0.022). No differences could be found for DASH score. Healing failure rate was higher in the control group (p = 0.002). Conclusion: Biologic augmentation of ARRCR using a combination of microfractures, collagen patch graft, and subacromial injections of platelet concentrate is an effective strategy in improving tendon healing rate. Level of evidence: retrospective cohort study, level III.
Effets des caractéristiques physico-chimiques et biorhéologiques de l'eau sur la physiologie, les performances adaptatives et la sélection de l'habitat chez la sole commune Solea solea (Linnaeus, 1758)

La conchyliculture conduit a l’accumulation d’exopolysaccharides (EPS) a l’interface eau-sediment. Les EPS ont des effets rheologiques averes et sont de nature a affecter le travail ventilatoire des jeunes poissons qui colonisent les vasieres intertidales. L’objectif de l’etude etait d’evaluer l’effet des EPS sur les performances physiologiques et comportementales de la sole commune Solea solea. Une detresse ventilatoire est observee a partir de 4 mgEPS l 1, or sur le terrain, la concentration en EPS de l’eau peut atteindre 15 mg l 1. L’intensite de la contrainte diminue avec la taille des animaux. Une comparaison inter-specifique montre que les especes ayant une grande surface branchiale (plie, turbot) sont plus sensibles a l’augmentation de la viscosite de l’eau que les especes a faible surface branchiale (sole, solenette). Ni le taux metabolique basal ni la tolerance a l’hypoxie ne sont affectes par la teneur en EPS de l’eau. La teneur en oxygene de l’eau est un element limitant majeur de la croissance de la sole. A 30 % de saturation on observe une reduction de 60 % du registre metabolique aerobie. Cette diminution s’accompagne de modifications du processus digestif, avec une hausse significative de sa duree et de la quantite totale d’energie mobilisee (SDA). L’effet conjugue de l’hypoxie et des EPS sur la selection d’habitat est surprenant. En condition normoxique, les soles colonisent preferentiellement un milieu sans EPS. Cependant, en hypoxie, les soles occupent les milieux riches en EPS alors qu’elles cumulent les effets d’une baisse de disponibilite en oxygene et d’une augmentation du travail ventilatoire. Des hypotheses sont proposees pour expliquer ce resultat.
Examining the critical success factors related to enterprise resource planning: a case study in Ordu province

Enterprise Resource Planning (ERP) and success factors are systems that enable effective and efficient management of businesses by facilitating coordination and interaction among different units. Therefore, the decision to select the right and applicable ERP implementation and success factors for businesses is a crucial matter. However, due to the cost of ERP implementations and the lengthy adaptation periods for businesses, selecting the relevant systems and success factors requires careful consideration. Identifying ERP implementations and success factors that are suitable for the business processes and structure of the company is a significant decision-making problem, which can be considered as a gap in the literature. In this regard, this study used the Neutrosophic Decision Making Trial and Evaluation Laboratory (DEMATEL) method to analyze the critical success factors for ERP in production companies that had more than 10 employees. The results show that project management and top management support were the most important factors. The results have significant implications for business managers and stakeholders involved in the subject matter in terms of cost and resource efficiency as well as gaining competitive advantage.
Effects of acupuncture on gut microbiota and short-chain fatty acids in patients with functional constipation: a randomized placebo-controlled trial

Objective: To comprehensively evaluate the effect of acupuncture on gut microbiota, identify specific microbes closely related to the clinical efficacy of acupuncture, and explored the role of short-chain fatty acids (SCFAs). Methods: A randomized placebo-controlled trial was conducted with 80 FC patients and 28 healthy controls (HCs). FC patients randomly received 16 acupuncture (n = 40) or sham acupuncture (n = 40) sessions over 4 weeks; HCs received no treatment. The change in the proportion of patients with mean weekly complete spontaneous bowel movements (CSBMs) was considered as the primary outcome measure. Moreover, the composition and the predictive metabolic function of the gut microbiota from feceal samples were analyzed by 16S rRNA gene sequencing, while feceal SCFAs were identified via gas chromatography-mass spectrometry (GC-MS). Results: Compared to sham acupuncture, acupuncture significantly increased the proportion of CSBM responders, and improved spontaneous bowel movements (SBMs), straining, stool consistency, and quality of life. Moreover, Sequencing of 16S rRNA genes revealed that acupuncture improved β-diversity and restored the composition of gut microbiota. Specifically, the abundance of beneficial bacteria such as g_Lactobacillus increased while that of pathogenic bacteria such as g_Pseudomonas decreased after acupuncture, which were significantly correlated with alleviated symptoms. Moreover, ten microbes including g_Coprobacter, g_Lactobacillus, and g_Eubacterium_coprostanoligenes_group might be considered acupuncture-specific microbes, and formed a stable interaction network. Additionally, GC-MS analysis indicated that acupuncture increased the content of butyrate acid in the gut, which was positively correlated with an increase in defecation frequency and a decrease in acupuncture-related pathogens. Finally, acupuncture specific-microbes including g_Coprobacter, g_Lactobacillus, g_Pseudomonas, g_Eubacterium_coprostanoligenes_group, g_Erysipelotrichaceae_UCG. 003, g_Prevotellaceae_UCG. 001, and g_Rolstonia could accurately predict the clinical efficacy of acupuncture (AUC = 0.918). Conclusion: Acupuncture could effectively improve clinical symptoms in FC patients, and was associated with gut microbiota reshaping and increased butyrate acid levels. Moreover, key microbial genera such as g_Coprobacter and g_Lactobacillus was predictive of acupuncture efficacy in treating FC. Future studies are required to validate the causal relationship between key microbial genera and acupuncture clinical efficacy, and should explore further metabolic pathways for designing personalized treatment strategies. Clinical Trial Registration: http://www.chictr. org.cn, Identifier: ChiCTR2100048831.
Religiosity and Political Islam: Divergent Influences on Support for Terrorism

Abstract This study examines the intricate relationship between religion and attitudes towards terrorist violence, with a specific focus on individual sympathy for al-Qaeda and justification for suicide bombings. While religion has the capacity to promote both harmony and social cohesion, as well as division and conflict, it is crucial to explore the complex and contradictory nature of religious beliefs in relation to individuals’ attitudes towards terrorism. To address this paradox, the study differentiates between religion as a belief and religion as an ideology. Drawing from a subset of the 2011 Pew Global Attitudes Survey, encompassing countries with substantial Muslim populations (Egypt, Indonesia, Jordan, Lebanon, and Turkey), the research investigates how religiosity and political Islam influence public attitudes towards terrorism, considering political and economic grievances in these contexts. Multivariate statistical analysis suggests that religiosity and political Islam exhibit distinct associations with the justification of suicide bombings and support for al-Qaeda, and these dynamics vary across countries. Ultimately, the study underscores the importance of perceiving religiosity not as a threat but as a potential remedy to prevent extremism by fostering an educated and deeper understanding of religious principles.
Femininities, ruralities and alcohol geographies: Women’s life narratives of ‘going out’ and ‘staying in’ in an Australian country town

This thesis aims to better understand the relationship between women, age, rurality and alcohol. Specifically this thesis is concerned with transformations in women’s drinking over life-courses. The entry point is women's narratives of ‘going out’ or ‘staying in’. Using a mix-method approach informed by post-structural feminist concepts, interviews and photo diaries of women from a country town in Victoria, Australia, were unpacked using discourse and narrative analysis. Attention was given to explore the different ways these women use or avoid alcohol, to make sense of themselves, their relationships with others and the places they live in as rural. Results explore sets of ideas about gendered responsibilities, classed and aged respectabilities and appropriate rural femininities that are key in shaping and reshaping the reciprocal relationships that forge drinking subjectivities, practices and places.
Collagen Hydrolysates: A Source of Bioactive Peptides Derived from Food Sources for the Treatment of Osteoarthritis

Osteoarthritis (OA) is the most common joint disorder, with a social and financial burden that is expected to increase in the coming years. Currently, there are no effective medications to treat it. Due to limited treatment options, patients often resort to supplements, such as collagen hydrolysates (CHs). CHs are products with low molecular weight (MW) peptides, often between 3 and 6 kDa, and are a result of industrialized processed collagen. Collagen extraction is often a by-product of the meat industry, with the main source for collagen-based products being bovine, although it can also be obtained from porcine and piscine sources. CHs have demonstrated positive results in clinical trials related to joint health, such as decreased joint pain, increased mobility, and structural joint improvements. The bioactivity of CHs is primarily attributed to their bioactive peptide (BAP) content. However, there are significant knowledge gaps regarding the digestion, bioavailability, and bioactivity of CH-derived BAPs, and how different CH products compare in that regard. The present review discusses CHs and their BAP content as potential treatments for OA.
Analisis Pengaruh Struktur Modal terhadap Profitabilitas pada Perusahaan LQ45 di BEI Periode 2012-2016

This research is to test the effect of Capital Structure with proxy Debt to equity Ratio, and Debt to asset Ratio to return on equity at LQ45 companies listed in Indonesian Stock Exchange for period 2012-2016. The Population of this research are all companies listed in Indonesian Stock Exchange. Sampling technique used in the research is purposive sampling so that yield 45 sample company of LQ45.The data are analysed with multiple regression by means of SPSS. The results indicate that Partially debt to equity ratio have significan to return on equity ,Conversely debt to asset ratio does not have significant influence towards return on equity. Simultaneously debt to equity ratio and debt to asset ratio have significant influence to return on equity return on equity. (H2) debt to assets ratio (X2) price to book value . (2012:9) debt to asset ratio positif return on equity pada real estate and
Role of Metformin in Polycystic Ovary Syndrome (PCOS)-Related Infertility

Polycystic ovarian syndrome (PCOS) is considered the most prevalent endocrinological disorder, which affects some women and it is characterized by anovulation and hyperandrogenism, with morphologic changes in the ovary, inappropriate gonadotropin secretion, and insulin resistance (IR) with accompanying compensatory hyperinsulinemia. PCOS was associated with some degree of IR which probably contributes to hyperandrogenism. Many studies showed that metformin, when used to treat PCOS, significantly reduced serum androgen levels, improved insulin sensitivity, restored menstrual cyclicity, and was successful in triggering ovulation. As a result, metformin may be useful in treating PCOS-related infertility. The aim of this review was to clarify PCOS, its prevalence, particularly in Saudi Arabia, its pathogenesis, its impact on the patient's health, and to explain the uses of metformin, its mechanism of action, and its role in the treatment of PCOS-related infertility.
Testis exposure to unopposed/elevated activin A in utero affects somatic and germ cells and alters steroid levels mimicking phthalate exposure

Correct fetal testis development underpins adult male fertility, and TGFβ superfamily ligands control key aspects of this process. Transcripts encoding one such ligand, activin A, are upregulated in testes after sex determination and remain high until after birth. Testis development requires activin signalling; mice lacking activin A (Inhba KO) display altered somatic and germ cell proliferation, disrupted cord elongation and altered steroid synthesis. In human pregnancies with pre-eclampsia, the foetus is inappropriately exposed to elevated activin A. To learn how this affects testis development, we examined mice lacking the potent activin inhibitor, inhibin, (Inha KO) at E13.5, E15.5 and PND0. At E13.5, testes appeared similar in WT and KO littermates, however E15.5 Inha KO testes displayed two germline phenotypes: (1) multinucleated germ cells within cords, and (2) germ cells outside of cords, both of which are documented following in utero exposure to endocrine disrupting phthalates in rodents. Quantitation of Sertoli and germ cells in Inha KO (modelling elevated activin A) and Inhba KO (low activin A) testes using immunofluorescence demonstrated activin A bioactivity determines the Sertoli/germ cell ratio. The 50% reduction in gonocytes in Inha KO testes at birth indicates unopposed activin A has a profound impact on embryonic germ cells. Whole testis RNAseq on Inha KO mice revealed most transcripts affected at E13.5 were present in Leydig cells and associated with steroid biosynthesis/metabolism. In agreement, androstenedione (A4), testosterone (T), and the A4:T ratio were reduced in Inha KO testes at E17.5, confirming unopposed activin A disrupts testicular steroid production. E15.5 testes cultured with either activin A and/or mono-2-ethylhexyl phthalate (MEHP) generated common histological and transcriptional outcomes affecting germline and Leydig cells, recapitulating the phenotype observed in Inha KO testes. Cultures with activin A and MEHP together provided evidence of common targets. Lastly, this study extends previous work focussed on the Inhba KO model to produce a signature of activin A bioactivity in the fetal testis. These outcomes show the potential for elevated activin A signalling to replicate some aspects of fetal phthalate exposure prior to the masculinization programming window, influencing fetal testis growth and increasing the risk of testicular dysgenesis.
The Effect of Digital Mindfulness Interventions on Depressive, Anxiety, and Stress Symptoms in Pregnant Women: A Systematic Review and Meta-Analysis

Introduction. Pregnancy is a unique time in a woman’s life that can be both exciting and challenging. It is also a period that can be associated with significant stress, anxiety, and depression, which can have negative consequences for both the mother and the baby. Mindfulness interventions are known to be a well-suited treatment and prevention method for psychiatric symptoms in pregnancy, and web-based applications have been explored. We here present an up-to-date systematic review and meta-analysis of randomized–controlled trials to investigate the effect of digital-based mindfulness interventions on depressive, anxiety, and stress symptoms during pregnancy. Methods. The systematic literature search and data extraction was performed by two independent raters. It resulted in 13 eligible studies overall comprising 1373 participants. We conducted random-effects meta-analyses for depressive, anxiety, and stress symptoms after completion of a digital mindfulness intervention (compared to a control group). Results. Digital mindfulness intervention methods were significantly able to reduce depression (g = −0.47, 95% CI [−0.9; −0.09]) and anxiety symptoms (g = −0.41, 95% CI [−0.77; −0.05]), but not stress symptoms. These effects were moderated by the attrition rate (βDepression = 0.025, pDepression < 0.01; βAnxiety = 0.022, pAnxiety < 0.01; βStress = 0.022, pStress < 0.01). Primiparity also had a significant influence on the intervention effect regarding depression symptoms (β = 0.033, p = 0.024). Conclusions. Digital mindfulness interventions are a promising method to reduce mental health symptoms in pregnant women. We identified certain parameters moderating this effect, for example, primiparity and the attrition rate.