Miracle-dz/UniFAR-FTUs huggingface dataset:
Neuronal and glial characterization in the rostrocaudal axis of the human anterior olfactory nucleus: Involvement in Parkinson’s disease

Hyposmia is one of the prodromal symptoms of Parkinson’s disease (PD) and a red flag in clinical diagnosis. Neuropathologically, this sign correlates with α-synuclein involvement in the anterior olfactory nucleus (AON). Neurodegeneration, microgliosis, and astrogliosis in AON are poorly studied, and bulbar AON is the focus of these studies with contradictory results. Additionally, male sex is a risk marker for developing PD, but sexual dimorphism of neural and glial populations in the AON has rarely been considered. The aim of this study was to analyze the density of NeuN, Iba-1, GFAP, and Lewy bodies (LBs), as well as the relationship of these cell type markers with pathology along the rostrocaudal axis of the AON (bulbar, retrobulbar, cortical anterior, and posterior divisions). Cavalieri, optical fractionator, and area fraction fractionator stereological approaches were used for the volume, cell populations and LBs densities, area fraction, and percentage of overlap. Iba-1 and α-syn intensities were measured using ImageJ. In non-PD (NPD) cases, the volume was lower in the AON at the extremes of the rostrocaudal axis than in the intermediate divisions. Cortical anterior AON volume decreased in PD compared with NPD cases. NeuN density decreased rostrocaudally in AON portions in NPD and PD cases. This occurred similarly in Iba-1 but only in PD samples. Iba-1 intensity significantly increased in bulbar AON between PD and NPD. No changes were found in astrocytes. Eight percent of NeuN, 0.1% of Iba-1, and 0.1% of GFAP areas overlapped with LBs area along the AON portions. The data indicate that bulbar AON, which is the most rostral portion in this axis, could play a major role in the pathology. This could be related to the larger area occupied by LBs in these divisions.
BINET'S FORMULA FOR THE TRIBONACCI SEQUENCE

The terms of a recursive sequence are usually defined by a recurrence procedure; that is, any term is the sum of preceding terms. Such a definition might not be entirely satisfactory, because the computation of any term could require the computation of all of its predecessors. An alternative definition gives any term of a recursive sequence as a function of the index of the term. For the simplest nontrivial recursive sequence, the Fibonacci sequence, Binet's formula [1] _ un = (l//5)(a" B")
Current Trends in Blood Flow Restriction

Purpose: The purpose of the study was to explore how individuals in the United States of America applied BFR/KAATSU devices and administered BFR/KAATSU training. In addition, the study sought to examine safety topics related to BFR/KAATSU training. Methods: The study was completed using survey research. Subjects were recruited through Facebook, email, and word of mouth. The survey was developed, piloted, and finally deployed March 22, 2021-April 21, 2021. Results: In total, 148 consented to the research; 108 completed the survey, and of those 108, 70 indicated current use with BFR/KAATSU equipment. Professions represented included athletic training, personal training, physical therapy, and strength and conditioning. Among those currently using BFR/KAATSU training (n = 70), the following results were found. The most common devices used were inflatable devices (n = 43, 61.4%). Education completed prior to device administration was formal (n = 39, 55.7%) and/or self-directed (n = 37, 52.9%). Barriers were faced by 29 (41.4%) when trying to enact training. Techniques and parameters varied during application. Screening processes were used (n = 50, 71.4%) prior to training. The devices were used to determine restrictive pressure (n = 31, 44.3%), and a supine position was used most when determining initial restrictive pressure (n = 33, 47.1%). For subsequent restrictive pressure measurements, respondents repeated the same method used initially (n = 38, 54.3%). Workload was often defined as the length of time under tension/load (n = 22, 31.4%) and exercise was directly supervised (n = 52, 74.3%). Adverse effects included bruising, lightheadedness, and cramping (n = 15, 21.4%). The devices have also been applied on those with pathology (n = 16, 22.9%). Conclusion: Those using blood flow restriction/KAATSU devices came from several professions and used an assortment of devices for BFR/KAATSU training. Individuals applied devices using a variety of parameters on populations for which efficacy has and has not been well defined.
G2019S LRRK2 Mutation Enhances MPP+-Induced Inflammation of Human Induced Pluripotent Stem Cells-Differentiated Dopaminergic Neurons

Induced pluripotent stem cells (iPSCs) offer an unprecedented opportunity to mimic human diseases of related cell types, but it is unclear whether they can successfully mimic age-related diseases such as Parkinson’s disease (PD). We generated iPSCs lines from three patients with familial PD associated with the G2019S mutation in the LRRK2 gene and one age-matched healthy individual (control). During long-term culture, dopaminergic (DA) neurons differentiated from iPSCs of G2019S LRRK2 PD patients exhibited morphological changes, including a reduced number of neurites and neurite arborization, which were not evident in DA neurons differentiated from control iPSCs. To mimic PD pathology in vitro, we used 1-methyl-4-phenylpyridium (MPP+) to damage DA neurons and found that DA neurons differentiated from patients with G2019S LRRK2 mutation significantly reduced the survival rate and increased apoptosis compared with the controls. We also found that the mRNA level of inflammatory factors [interleukin (IL)-1β, tumor necrosis factor-α, cyclooxygenase-2, IL-6, and inducible NO synthase] with G2019S LRRK2 mutation were higher than control group after exposure to MPP+. Our study provides an in vitro model based on iPSCs that captures the patients’ genetic complexity and investigates the pathogenesis of familial PD cases in a disease-associated cell type.
Functional Properties of Protein Hydrolysates on Growth, Digestive Enzyme Activities, Protein Metabolism, and Intestinal Health of Larval Largemouth Bass (Micropterus salmoides)

The present study was conducted to investigate the effects of dietary inclusion of protein hydrolysates on growth performance, digestive enzyme activities, protein metabolism, and intestinal health in larval largemouth bass (Micropterus salmoides). The experimental feeding trial presented in this study was based on five isonitrogenous and isolipidic diets formulated with graded inclusion levels of protein hydrolysates, and it showed that protein hydrolysates improved growth performance, reduced larval deformity rate, and increased the activity of digestive enzymes, including pepsin and trypsin. Gene expression results revealed that the supplementation of protein hydrolysates upregulated the expression of intestinal amino acid transporters LAT2 and peptide transporter 2 (PepT2), as well as the amino acid transporters LAT1 in muscle. Dietary provision of protein hydrolysates activated the target of rapamycin (TOR) pathway including the up-regulation of TOR and AKT1, and down-regulation of 4EBP1. Additionally, the expression of genes involved in the amino acids response (AAR) pathway, ATF4 and REDD1, were inhibited. Protein hydrolysates inhibited the transcription of some pro-inflammatory cytokines, including IL-8 and 5-LOX, but promoted the expression of anti-inflammatory cytokines TGF-β and IL-10. The 16S rRNA analysis, using V3-V4 region, indicated that dietary protein hydrolysates supplementation reduced the diversity of the intestine microbial community, increased the enrichment of Plesiomonas and reduced the enrichment of Staphylococcus at the genus level. In summary, protein hydrolysates have been shown to be an active and useful supplement to positively complement other protein sources in the diets for largemouth bass larvae, and this study provided novel insights on the beneficial roles and possible mechanisms of action of dietary protein hydrolysates in improving the overall performance of fish larvae.
The Relations of Attention to and Clarity of Feelings With Facial Affect Perception

Attention to emotions and emotional clarity are core dimensions of individual differences in emotion awareness. Findings from prior research based on self-report indicate that attention to and recognition of one’s own emotions are related to attention to and recognition of other people’s emotions. In the present experimental study, we examined the relations of attention to and clarity of emotions with the efficiency of facial affect perception. Moreover, it was explored whether attention to and clarity of emotions are linked to negative interpretations of facial expressions. A perception of facial expressions (PFE) task based on schematic faces with neutral, ambiguous, or unambiguous emotional expressions and a gender decision task were administered to healthy individuals along with measures of emotion awareness, state and trait anxiety, depression, and verbal intelligence. Participants had to decide how much the faces express six basic affects. Evaluative ratings and decision latencies were analyzed. Attention to feelings was negatively correlated with evaluative decision latency, whereas clarity of feelings was not related to decision latency in the PFE task. Attention to feelings was positively correlated with the perception of negative affects in ambiguous faces. Attention to feelings and emotional clarity were not related to gender decision latency. According to our results, dispositional attention to feelings goes along with an enhanced efficiency of facial affect perception. Habitually paying attention to one’s own emotions may facilitate processing of external emotional information. Preliminary evidence was obtained suggesting a relationship of dispositional attention to feelings with negative interpretations of facial expressions.
Nano-Metal–Organic Framework Decorated With Pt Nanoparticles as an Efficient Theranostic Nanoprobe for CT/MRI/PAI Imaging-Guided Radio-Photothermal Synergistic Cancer Therapy

The multifunctional theranostic nanoplatforms, which can realize changing the contrasts of medical images and enhance cancer therapies simultaneously, have attracted tremendous attention from chemists and medicine in past decades. Herein, a nanoscale metal–organic framework-based material was first synthesized and then decorated with platinum (NMOF545@Pt) successfully for multimodal imaging-guided synergistic cancer therapy. The obtained NMOF545@Pt is advantageous in shortening the longitudinal relaxation time (T1), enhancing photoacoustic effects, and elevating X-ray absorption efficiently. Thus, the enchantments of tripe imaging modalities, computed tomography (CT)/magnetic resonance imaging (MRI)/photoacoustic imaging (PAI), were realized with NMOF545@Pt administration simultaneously and can be cleared from the mice. Meanwhile, in vitro and in vivo experiments demonstrate that the synthesized NMOF545@Pt can dramatically increase photothermal therapy (PTT) and radiotherapy (RT) efficacy. Convincing evidence proves that tumor growth can be wholly inhibited without noticeable side effects or organ damage. The results demonstrated the promise of multifunctional nanocomposites NMOF545@Pt to improve biomedical imaging and synergistic tumor treatments.
Single-Cell RNA Sequencing Unravels Distinct Tumor Microenvironment of Different Components of Lung Adenocarcinoma Featured as Mixed Ground-Glass Opacity

Lung adenocarcinoma featured as mixed ground-glass opacity (mGGO) doubled its volume half of the time in comparison with that featured as pure ground-glass opacity (pGGO). The mechanisms underlying the heterogeneous appearance of mGGO remain elusive. In this study, we macro-dissected the solid (S) components and ground-glass (GG) components of mGGO and performed single-cell sequencing analyses of six paired components from three mGGO patients. A total of 19,391 single-cell profiles were taken into analysis, and the data of each patient were analyzed independently to obtain a common alteration. Cancer cells and macrophages were the dominant cell types in the S and GG components, respectively. Cancer cells in the S components, which showed relatively malignant phenotypes, were likely to originate from both the GG and S components and monitor the surrounding tumor microenvironment (TME) through an intricate cell interaction network. SPP1 hi macrophages were enriched in the S components and showed increased activity of chemoattraction, while macrophages in the GG components displayed an active antimicrobial process with a higher stress-induced state. In addition, the CD47–SIRPA axis was demonstrated to be critical in the maintenance of the GG components. Taken together, our study unraveled the alterations of cell components and transcriptomic features between different components in mGGOs.
Fintech, Bank Risk-Taking, and Risk-Warning for Commercial Banks in the Era of Digital Technology

Fintech risks commercial banks in three ways, particularly operational efficiency, financial innovation, and risk management. Based on the data of 37 Chinese-listed commercial banks from 2011 to 2020, the study empirically analyzes the impact of fintech on bank risk-taking, and the intermediary effects of the three channels, such as operational efficiency, financial innovation, and risk management. The results show that fintech can effectively reduce the risk of banks. The results of heterogeneity analysis revealed that fintech strongly affects the risk-taking of state-owned banks but not obviously for rural commercial banks. Financial efficiency, financial innovation, and risk management indirectly affect the risk-taking of banks that contributed 8.51, 7.18, and 5.77%, respectively. We also constructed the commercial bank risk-warning index. Based on the quarterly data of banks from 2011 to 2020, we empirically tested the early warning effect of the bank risk-warning index. The results showed that when the signal month is set to 12 months, the bank risk-warning index can have a warning effect in this period.
ANGULAR CORRELATION OF SUCCESSIVE GAMMA-RAYS

yields very definite information concerning the parities of the nuclear levels involved. The ambiguities left in the examples discussed in this paper arise from a paucity of theoretical predictions for higher multipole transitions, to the possibility of interference for mixed radiation, and to the preliminary character of the angular correlation data. If these obstacles are eliminated the experiments with the polarimeter have only to decide the existence or non-existence of a polarization in the position (8) at which we expect the largest efFect. "For this purpose the polarimeter described in this paper has sufhcient sensitivity. For gamma-ray energies above a few hundred kev the correlation method compares favorably with other methods which lead to the assignment of spins to nuclear levels and of parity changes to the transitions between these levels. "p is largest at 8=90' in most of the cases, but not in all of them.
A two-stage minimax procedure with screening for selecting the largest normal mean (ii): an improved

This paper is a follow-up to an earlier article by the authors in which they proposed a two-stage procedure with screening to select the normal population with the largest population mean when the populations have a common known variance. The two-stage procedure has the highly desirable property that the expected total number of observations required by the procedure is always less than the total number of observations required by the corresponding single-stage procedure of Bechhofer (1954), regardless of the configuration of the population means. The present paper contains new results which make possible the more efficient implementation of the two-stage procedure. Tables for this purpose are given, and the improvements achieved (which are substantial) are assessed.
Validation of aModel Predicting That Physical Activities Improve Health-RelatedQuality of Life inOlder Japanese Adults with Pain, Dysesthesia, and Kinesiophobia after Lumbar Surgery: Structural Equation Modeling

Objectives. is study assessed the validity of a hypothesized model predicting that physical activity improves health-related quality of life (HRQOL) in older Japanese adults with pain, dysesthesia, and kinesiophobia following lumbar surgery.Methods. We included 431 elderly patients who underwent surgery for lumbar spinal stenosis at two hospitals. e frequency of physical activity, pain, dysesthesia, kinesiophobia (somatic focus and activity avoidance), and HRQOL were investigated using a questionnaire. Missing values were complemented by the stochastic regression imputation. We constructed the following model. (i) physical activity aects pain, dysesthesia, and kinesiophobia. (ii) pain, dysesthesia, and kinesiophobia separately aect HRQOL. is hypothetical model was tested by structural equation modeling. e model was improved based on a modied index. Results. Of the 431 respondents, 297 (median age 72 years, range 65–91 years; 158 men and 139 women) were analyzed (68.9%). e t of the model improved based on the modication index and was acceptable comparative t index, 0.948; Tucker–Lewis index, 0.919; root mean square error of approximation, 0.048 (90% condence interval, 0.026–0.069), and standardized root mean square residual (0.046). e paths by which physical activities reduced pain or dysesthesia (standardized pass coecients, −0.406) and somatic focus (−0.301) and consequently improved HRQOL were signicant (pain/dysesthesia, −0.684; somatic focus, −0.218). Discussion. Our hypothesized model predicting that physical activity improves HRQOL in terms of pain, dysesthesia, and kinesiophobia in older Japanese adults after lumbar surgery was validated using cross-sectional data. Interventional studies on physical activity based on this model are required to establish the model.
Primary care experiences of people who live with chronic pain and receive opioids to manage pain: A qualitative methodology

BACKGROUND AND PURPOSE The prevalence of chronic pain continues to rise and the majority of patients with chronic pain are managed in primary care. The purpose of this research was to provide the perspectives of patients who live with chronic pain and receive opioids to help manage their pain from primary care. METHODS In this qualitative study, 12 participants from a Midwest primary care clinic described their primary care experiences with receiving opioids for chronic pain. Thematic and interpretive analyses were used to understand the issues. CONCLUSIONS Participants receiving opioids for pain management through primary care feared losing access to opioids, wanted to protect sobriety when they had histories of substance use disorder, experienced stress at their jobs with frequent appointments, identified inconsistencies in health care prolonging their suffering and increasing substance misuse, and identified improvement in coping with pain when they had confidence in healthcare providers. IMPLICATIONS FOR PRACTICE Providing patient-centered care while managing patients with pain and unknown risk for prescription opioid misuse is possible. Understanding influences that create prescription opioid risk for misuse can help nurse practitioners improve their delivery of care by providing consistent and convenient healthcare encounters, and help patients protect themselves from risk of prescription opioid misuse.
Grief Support Groups Used by Few—: Are Bereavement Needs Being Met?

Few adult bereaved attend closed grief support groups, yet many of those who do attend say they are extremely helpful. This research explores factors influencing support group attendance, and the extent to which bereavement support needs are being met. Focus group discussions reveal that a broad scope of sources of support is available to the bereaved. Results show what is seen as unhelpful to them, and what might be more helpful to them. The study indicates many adult bereaved suffer from an overall lack of support and would benefit from more caring overtures from those around them. Findings from this small frontline hospice bereavement study point toward ideas for adjustments in support groups and innovative bereavement education and programming.
New measurements of Ω m from gamma–ray bursts

Context. Data from cosmic microwave background radiation (CMB), baryon acoustic oscillations (BAO), and supernovae Ia (SNe-Ia) support a constant dark energy equation of state with w 0 ∼ − 1. Measuring the evolution of w along the redshift is one of the most demanding challenges for observational cosmology. Aims. We discuss the existence of a close relation for GRBs, named Combo-relation, based on characteristic parameters of GRB phenomenology such as the prompt intrinsic peak energy E p , i , the X-ray afterglow, the initial luminosity of the shallow phase L 0 , the rest-frame duration τ of the shallow phase, and the index of the late power-law decay α X . We use it to measure Ω m and the evolution of the dark energy equation of state. We also propose a new calibration method for the same relation, which reduces the dependence on SNe Ia systematics. Methods. We have selected a sample of GRBs with 1) a measured redshift z ; 2) a determined intrinsic prompt peak energy E p , i , and 3) a good coverage of the observed (0.310) keV afterglow light curves. The ﬁtting technique of the rest-frame (0.310) keV luminosity light curves represents the core of the Combo-relation. We separate the early steep decay, considered a part of the prompt emission, from the X-ray afterglow additional component. Data with the largest positive residual, identiﬁed as ﬂares, are automatically eliminated until the p-value of the ﬁt becomes greater than 0.3. Results. We strongly minimize the dependency of the Combo-GRB calibration on SNe Ia. We also measure a small extra-Poissonian scatter of the Combo-relation, which allows us to infer from GRBs alone Ω M = 0 . 29 + 0 . 23 − 0 . 15 (1 σ ) for the Λ CDM cosmological model, and Ω M = 0 . 40 + 0 . 22 − 0 . 16 , w 0 = − 1 . 43 + 0 . 78 − 0 . 66 for the ﬂat-Universe variable equation of state case. Conclusions. In view of the increasing size of the GRB database, thanks to future missions, the Combo-relation is a promising tool for measuring Ω m with an accuracy comparable to that exhibited by SNe Ia, and to investigate the dark energy contribution and evolution up to z ∼ 10.
Boosting worst-group accuracy without any group annotations

Despite having good average test accuracy, classiﬁcation models can have poor performance on subpopulations that are not well represented in the training data. In this work, we introduce a criterion to estimate the accuracy on these populations. This allows us to design a procedure that achieves good worst-group performance and unlike previous procedures requires no group labels. We provide a sound empirical investigation of our procedure and show that it recovers the worst-group performance of methods that use oracle group annotations.