Miracle-dz/UniFAR-FTUs huggingface dataset:
Fixed-duration (FD) first-line treatment (tx) with ibrutinib (I) plus venetoclax (V) for chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL): Primary analysis of the FD cohort of the phase 2 captivate study.

7501 Background: CAPTIVATE (PCYC-1142) is a multicenter phase 2 study of first-line I+V in CLL. We previously reported results from the Minimal Residual Disease (MRD) cohort wherein undetectable MRD (uMRD) was achieved in over two-thirds of patients (pts) with 12 cycles of I+V, and 30-mo PFS rates were ≥95% irrespective of subsequent randomized treatment (Wierda, ASH 2020). We now present results from the FD cohort, evaluating fixed-duration tx with I+V. Methods: Pts aged ≤70 y with previously untreated CLL/SLL received 3 cycles of I then 12 cycles of I+V (I 420 mg/d orally; V ramp-up to 400 mg/d orally). Primary endpoint was CR rate, including CR with incomplete recovery (CRi); secondary endpoints were ORR, duration of response, uMRD rate (<10-4 by 8-color flow cytometry), PFS, OS, tumor lysis syndrome (TLS) risk reduction, and adverse events (AEs). Results: 159 pts were enrolled (median age 60 y). High-risk features included del(17p)/ TP53 mutation, 17%; del(11q), 18%; complex karyotype, 19%; and unmutated IGHV, 56%. 147 (92%) and 149 (94%) pts completed planned tx with I and V, respectively. Median time on study was 27.9 mo (range, 0.8–33.2). With fixed-duration I+V, CR rate was 55% (95% CI 48–63) in the overall population and was consistent across high-risk subgroups. Of the 88 pts who achieved CR, 78 (89%) had durable CR (duration ≥1 y); 1 died 7 mo after CR, and 9 with <1 y follow-up were not evaluable. ORR was 96%. Best uMRD response was achieved in 77% of pts in peripheral blood (PB) and 60% of pts in bone marrow (BM). 24-mo PFS was 95%; 24-mo OS was 98%. Results were similar in pts without del(17p) (n=136) (Table). In pts with del(17p)/ TP53 mutation (n=27), CR rate was 56%, uMRD rate was 81% (PB) and 41% (BM), and 24-mo PFS was 84% (95% CI 63–94). Of 34 pts with high baseline TLS risk based on tumor burden, 32 (94%) shifted to medium or low risk after I lead-in; no TLS occurred. AEs were primarily grade 1/2. Most common grade 3/4 AEs were neutropenia (33%), hypertension (6%), and neutrophil count decreased (5%). AEs led to discontinuation of I in 4% and V in 2%. Conclusions: First-line I+V is an all-oral, once-daily, chemotherapy-free, fixed-duration regimen that provides deep, durable responses in pts with CLL/SLL, including those with genomic high-risk features. CR, uMRD rates, PFS, and OS appear favorable. The safety profile of I+V was consistent with known AEs for each agent; no new safety signals were identified. Clinical trial information: NCT02910583. [Table: see text]
Making moves: Lateral reading and strategic thinking during digital source evaluation

Using screencasting videos as think-alouds, this case study explores the process three high school seniors used when tasked with evaluating digital sources. Drawing from dual level theory of literacy, the study explores the complexities involved when students are asked to conduct informal research of their source (a strategy called lateral reading) in order to improve their ability to uncover potential bias in digital sources. Results indicate that lateral reading encouraged healthy reader skepticism and slowed readers down in the review, but students lacked sophisticated online reading and research strategies.
Understanding emerging adult identity development through work at a residential outdoor environmental education program: an application of social practice theory

Abstract Most previous research on residential outdoor environmental education (ROEE) programs has focused on the outcomes associated with student participation in these learning experiences. In contrast to these previous studies, this research takes an interpretivist approach to understand how work as a short-term instructor in a ROEE setting may also uniquely support learning and development for this population as well. A sample of former short-term instructors across the developmental period of emerging adulthood were interviewed to retrospectively explore the meaning that work in a single ROEE program holds in their current lives. Inductive analysis found social practice theory effectively aligned with the meaning former short-term instructors associated with program involvement. These findings suggest that short-term instructor work influenced individuals’ identity development processes in both a social-emotional and pro-environmental manner. Moving past their ROEE experience, former short-term instructors attempted to live out meaningful practices associated with these program-related identities, such as sharing the outdoors with others. Implications for both professional development in a ROEE setting and future research are discussed.
Semi-Supervised Learning Using Hierarchical Mixture Models: Gene Essentiality Case Study

Integrating gene-level data is useful for predicting the role of genes in biological processes. This problem has typically focused on supervised classification, which requires large training sets of positive and negative examples. However, training data sets that are too small for supervised approaches can still provide valuable information. We describe a hierarchical mixture model that uses limited positively labeled gene training data for semi-supervised learning. We focus on the problem of predicting essential genes, where a gene is required for the survival of an organism under particular conditions. We applied cross-validation and found that the inclusion of positively labeled samples in a semi-supervised learning framework with the hierarchical mixture model improves the detection of essential genes compared to unsupervised, supervised, and other semi-supervised approaches. There was also improved prediction performance when genes are incorrectly assumed to be non-essential. Our comparisons indicate that the incorporation of even small amounts of existing knowledge improves the accuracy of prediction and decreases variability in predictions. Although we focused on gene essentiality, the hierarchical mixture model and semi-supervised framework is standard for problems focused on prediction of genes or other features, with multiple data types characterizing the feature, and a small set of positive labels.
Synthesis and Oxygen Storage Capacities of Hexagonal Dy1–xYxMnO3+δ

Polycrystalline samples of hexagonal P63cm (space group No. 185) Dy1–xYxMnO3+δ were synthesized over complete solubility ranges under reducing conditions with oxygen partial pressures of 5 ppm to air at high temperatures (1200–1400 °C). All samples displayed unusually large, reversible oxygen content excess (0 ≤ δ ≤ 0.35) at low temperatures of ∼200–400 °C under air and oxygen atmospheres in thermogravimetric measurements. During heating, stoichiometric samples showed rapid uptakes of oxygen at 200–300 °C and equally fast releases of oxygen at 275–375 °C when materials transformed back to the stoichiometric P63cm phase. Upon slow cooling from the stoichiometric P63cm phase, all samples displayed rapid uptakes of oxygen at 200–350 °C. Similar changes were observed as a function of oxygen partial pressure at constant temperature. Increased, reversible changes in oxygen content were also achieved by high-pressure annealings in oxygen and hydrogen reduction at 400 °C. Thermogravimetric and X-ray diffraction m.
Altered Brain Network Degree Centrality in Major Depressive Disorder via Electro-Acupuncture Stimulation at Baihui(gv20)

Background: Although the acupuncture treatment of major depressive disorder(MDD) has been recognized by the latest clinical practice guidelines of the American Academy of Internal Medicine, complex therapeutic mechanisms need further to clarify. The aim of the study is investigate whether the aberrant resting state brain network in MDD patients could be regulated by acupuncture at GV20 using functional magnetic resonance imaging(fMRI) combined with degree centrality(DC) method. Results: Compared to healthy subjects, MDD patients exhibited significantly aberrant DC in widely brain regions, including cortical(PFC, precuneus, temporal, insula) and sub-cortical (thalamus, putamen and caudate) structures. Furthermore, results showed that acupuncture at GV20 induced down-regulation the DC of abnormal brain regions in MDD patients. Conclusions: Our findings provide imaging evidence to support that GV20-related acupuncture stimulation may modulate the abnormal brain function state in MDD patients by using fMRI technique combined with DC analysis. This study may partly interpret the neural mechanisms of acupuncture at GV20 which is used to treat patients with MDD in clinical. Trial registration: ChiCTR, ChiCTR-IOR-15006357. Registered 05 May 2015, http://www.chictr. org.cn/showproj.aspx? proj=10922.
Qualitative Analysis of Factors Affecting Decision-Making Process of Infrastructure Project Selection

In practice, there are several factors affecting the decision-making process of infrastructure project selection, which may influence the decision makers in making investment decisions. Due to its significance, these influencing factors are explored in this study using a qualitative approach consisting of twenty semi-structured interviews with industry experts in the Indonesian context. Thematic coding analysis was used to analyze the collected data. Thirteen influencing factors have successfully identified and categorized based on their similarities into four groups, namely: personal attributes, cognitive abilities, technical factors, and intervention issues. Understanding these influencing factors is crucial in infrastructure project planning and selection since it will allow the decision makers to identify foreseeable problems and take precautionary steps in order to arrive at sound decisions. Finally, this paper presents the current practice of decision-making process for infrastructure project selection and highlights the influencing factors as an important issue that exists in the current practice.
Synthetic chalcone derivatives inhibit cytokine secretion via inhibition of ERK and JNK pathways in human U937 macrophage

Purpose: To investigate the inhibitory effects of a chalcone derivative on lipopolysaccharide (LPS)induced interleukin (IL)-6 and IL-8 secretions and on LPS-induced mitogen-activated protein kinases (MAPK) and nuclear factor kappa B (NF-κB) activation in human U937 macrophage-like cell line. Methods: The effects of chalcone derivative on LPS-induced secretion of IL-6 and IL-8 in endothelial cells were determined by enzyme-linked immunosorbent assay while the effects of chalcone on the activation of MAPK and NF-kB pathway were determined by Western blotting. Results: The results showed that 3-(5-methyl-furan-2-yl)-naphthalen-1-yl-propenone (compound 1) significantly inhibited the secretion of LPS-induced IL-6 and IL-8 in U937 macrophages. This compound also demonstrated significant suppression of c-Jun N-terminal kinases (JNK) and extracellular signalregulated kinases (ERK) phosphorylation. However, the compound did not reverse the degradation of inhibitor kappa B alpha (IκBα) and did not inhibit the phosphorylation of NF-κB subunit and P-38 MAPK. Conclusion: Compound 1 inhibits the secretion of cytokines via the inhibition of ERK and JNK pathways. These results suggest that chalcone derivative could act as an antiinflammatory agent by altering cytokine secretion and inflammatory pathways.
Fear of Covid-19 and Intentions towards Adopting E-Health Services: Exploring the Technology Acceptance Model in the Scenario of Pandemic

The aim of this paper was to investigate the link between fear of Covid-19 and individuals’ behavi oral intentions toward adopting e-health services by expanding the technology acceptance model (TAM) to incorporate fear of the Covid-19 factor. To empirically testing our proposed theoretical model, we conducted a research survey in Pakistan and collected data from 624 individuals utilizing a non-probability convenience sampling strategy. The outcomes of our study declare that fear of Covid19 are positively associated with individuals’ attitude and their subsequent behavioral intentions towards adopting e-health services. Perceived ease of use and perceived usefulness of e-health services mediated the relationship between fear of Covid-19 and individuals’ attitude towards adopting e -health services. This research is highly significant in the current scenario of Covid-19. Our study offers a theoretical model to understand why and how fear of Covid- 19 is related to an individual’s intentions for adopting e-health services. Moreover, this study also extends the literature of the technology acceptance model TAM by pinpoint the impact of fear of Covid-19. Contribution/Originality: This study investigates the link between fear of Covid- 19 and individuals’ behavioral intentions toward adopting e-health services by expanding the technology acceptance
The Effect of COVID-19 Pandemic on Consumer Online Purchasing Behavior

This study aimed to explore the impacts of COVID 19 pandemic on the consumer online purchasing behaviors in Jordan. A descriptive analytical approach was adopted. The population involves all the online consumers in Jordan who shopped online during the pandemic. The researcher passed the questionnaire forms to 200 students by email who were selected from three Jordanian universities that are located in Amman. Those students were selected randomly. All the forms were filled and retrieved. All the retrieved forms were analyzed statistically. The response rate is 100%. The questionnaire was developed by the researcher based on the literature that was reviewed. SPSS software was used. Means and standard deviations are calculated. The researcher concluded the COVID 19 pandemic has a moderate impact on consumer online purchasing behaviors in Jordan. That was concluded from the perspective of the students who are enrolled at Jordanian universities. The researcher found that there are differences between the respondents’ views which are attributed to gender for the favor of females. She recommends taking the recent purchasing trends into consideration when setting marketing plans by plan developers. © 2021, World Scientific and Engineering Academy and Society. All rights reserved.
Why Hong Kong millennial Christians switch from Chinese local churches to international churches: A qualitative study

In the past few years, there has been an observable phenomenon of Hong Kong millennial Christians moving from Chinese-speaking local churches to English-speaking international churches. To understand the reasons behind the movement, 30 Hong Kong millennial Christians who moved from local churches to international churches were interviewed in this study in four focus groups. Reasons for their movement include: local churches feel like formal education, churches emphasize works over grace, and churches are out of touch and irrelevant from the needs and struggles of millennials’ everyday lives. The international churches are more welcomed by Hong Kong millennial Christians as they have more to offer, including vulnerable leadership, approachable worship style, and a stronger sense of community. The results indicate the faith experience and challenges faced by Hong Kong millennial Christians in the postmodern culture, especially in the unique context of Hong Kong where Eastern culture meets Western. The research suggests a set of recommendations for churches wishing to attract and retain millennials, including the importance for churches to understand their congregants, be prepared for changes, be open to embrace and build an authentic genuine community of faith, and to own a clearly articulated vision. These will be truly helpful in cultivating the spiritual growth of our younger generations to find their place in these millennial-friendly churches.
Essential Oil Composition of Two Grammosciadium DC Species, G. platycarpum (Boiss et Hausskn) Schischk and G. macrodon Boiss (Apiaceae), from Turkey

Purpose: To investigate and compare the essential oil composition of two Grammosciadium species obtained by hydrodistillation Methods: The essential oil of the aerial parts of two species was obtained by hydrodistillation and analyzed by gas chromatography (GC) and gas chromatography - mass spectrometry (GC-MS). Results: In G. platycarpum , twenty-seven compounds were identified representing 99.3 % of the total oil. The major constituents of the oil were limonene (28.4 %), β-pinene (16.1 %), β-selinene (15.9 %), δ- 3-carene (11.2 %), α-farnesene (6.0 %) and p - cymene (4.7 %). The oil of G. macrodon contained thirty-seven components representing 94.4 % of the total oil, with caryophyllene oxide (15.9 %), germacrene - D (12.4 %), β-caryophyllene (11.5 %), δ-3 - carene (10.1 %) and cyclohexane (4.6 %) as the main constituents. Conclusion: The essential oil composition of G. macrodon was analysed for the first time, the most abundant constituents being caryophyllene oxide, and cyclohexane. Keywords: Grammosciadium macrodon , Grammosciadium platycarpum , Essential oil, Limonene, Caryophyllene oxide, Germacrene - D, β-Caryophyllene, δ-3-Carene
Adoption of dual-purpose sweetpotato varieties under partial population exposure in Rwanda: Insights from an African plant breeding programme

As part of the Green Revolution, plant breeding programmes such as the African Centre for Crop Improvement have trained scientists to breed crop varieties in Africa to address the challenges of low productivity. However, exposure to and adoption of these varieties is somewhat modest, and there is also a scarcity of empirical studies on the drivers of exposure and adoption. Using data from Rwanda, the counterfactual treatment effect framework was used to estimate observed and potential adoption rates, as well as the drivers of exposure and adoption of dual-purpose sweetpotato varieties bred for both food and feed, under partial exposure to information. The results show that if the entire target farming population had been aware of the varieties, the adoption rate could have been up to 70% instead of the observed rate of 42%, indicating a 28% adoption gap due to partial diffusion. The findings indicate that once these varieties have been exposed, there is scope for further expansion of their cultivation. Key drivers of variety exposure and adoption include membership of farmer groups, participation in demonstration fields, and access to extension services. Thus, conscious efforts to minimize information constraints are a prerequisite for unlocking this adoption puzzle.
Transparency in public administration as a challenge for a good democratic governance

In democratic societies, the transparency of public institutions is essential. Increasingly, developed or developing countries recognize that free access to information is fundamental to democracy. Whether we are talking about the government or the private companies that manage public services, access to the data held by these organizations means increasing accountability and allows citizens to know what these organizations do and what they use public money for. Access to information develops citizens' trust in public institutions, enabling citizens to understand public policy decisions and monitor their implementation. The purpose of our research is to identify the degree of transparency of the ministries in the Romanian Government. The research was based on public data and information identified on the websites of 18 ministries in the current structure of the Romanian Government, but also on data collected using online questionnaires answered by 45 officials from the Information and Documentation Departments of the ministries. The data and information obtained were processed in excel and SPSS. The database was completed with the evaluation reports on the implementation of Law 52/2003 on decisional transparency in the Romanian public administration, from 2017-2020. The results of our research show that ministries have made progress in ensuring administrative transparency. However, administrative transparency remains a challenge for Romanian government ministries. The results obtained are useful and interesting for both the field of knowledge and for ministries to help them identify ways to increase transparency for better democratic governance.
Oxidative Degradation of Aqueous 2-Amino-2-methyl-1-propanol Solvent for Postcombustion CO2 Capture

2-Amino-2-methyl-1-propanol (AMP) and the blends of AMP with other amines appear to be commercially attractive solvents for postcombustion CO2 capture by absorption/stripping. Oxidative degradation experiments involving AMP aqueous solutions were performed in a 200 mL glass batch reactor with initial AMP concentrations of 5 mol·kg–1, oxygen partial pressures of 250–350 kPa, and at temperatures of 100–140 °C in order to elucidate the degradation mechanistic pathways. The amine loss was determined by cation ion chromatography (IC), while the degradation compounds were identified and quantified by gas chromatography–mass spectrometry (GC–MS) and anion IC. The possible chemical pathways of AMP oxidative degradation are proposed on the basis of the identified and quantified products and the context of the current amine degradation schemes. The role of O2 in the proposed pathways is much more explicit than the previously proposed MEA oxidation mechanisms.
Effects of high-intensity ultrasonic bath on the quality of strawberry juice

ABSTRACT The effects of ultrasound (US) application conditions on microbiological, physicochemical, microscopic, and sensory features of strawberry juice were evaluated. Conditions comprised US (40 kHz) for 5, 10, or 15 min at 25, 40, or 50°C. All US treatments reduced the microbial count in juice. US treatment (40°C/10 min; 50°C/15 min) reduced the °Brix value. All treatments maintained the pH, total titratable acidity, phenolic compounds, and antioxidant capacity of the samples. The thermal treatment sample presented a higher decrease in bioactive compounds. Hue angle values and changes in optical microscopy have increased as treatment temperature and time increased. The sample sonicated at 50°C for 15 min presented lower sensory acceptance indices for all the evaluated attributes. Ultrasound application at 50°C for 5 min presented effective juice properties’ conservation, a good sensory acceptance, and is a promising alternative to help preserve strawberries.
Willingness to pay for improved safe drinking water in a coastal urban area in Bangladesh

Discontentment with a piped supply system of drinking water has become a significant concern in Bangladesh's urban areas in recent years, necessitating the improvement of different aspects of the system in question. Therefore, by conducting a discrete choice experiment on 115 households out of a systematically selected 161 households, this study aims to estimate the willingness to pay (WTP) for an improved safe drinking water supply by considering the trade-offs made by urban dwellers for the proposed improvements to an existing water supply system in the Khulna City Corporation (KCC) area of Bangladesh. The primary results show that the total WTP of households is estimated at BDT 243.6 (≈US$ 2.87) per month, implying that respondents are ready to pay for improvements to the water supply attributes of water quality, regularity of supply, water pressure in taps, and filtering. A revenue stream for an improved water supply system is also being developed, suggesting that investment in improving the system would be a ‘no-regret’ decision and economically sustainable.