Miracle-dz/UniFAR-FTUs huggingface dataset:
An Observational Study of the Relationship between Excessively Strong Short Rains in Coastal East Africa and Indian Ocean SST

Abstract Composites of SST, wind, rainfall, and humidity have been constructed for years of high rainfall during September, October, and November (SON) in equatorial and southern-central East Africa. These show that extreme East African short rains are associated with large-scale SST anomalies in the Indian Ocean that closely resemble those that develop during Indian Ocean dipole or zonal mode (IOZM) events. This is corroborated by the observation that strong IOZM events produce enhanced East African rainfall. However, it is also shown that the relationship between the IOZM and East African rainfall is nonlinear, with only IOZM events that reverse the zonal SST gradient for several months (extreme events) triggering high rainfall. Comparison of the wind anomalies that develop during extreme IOZM events with those that develop during weaker (moderate) events shows that strong easterly anomalies in the northern-central Indian Ocean are a persistent feature of extreme, but not of moderate, IOZM years. It is .
Giant clams as open-source, scalable reef environmental biomonitors

Valvometry, the electronic measurement of bivalve shell opening and closing, has been demonstrated to be a valuable biomonitoring technique in previous ecological and environmental studies. Valvometric data has been shown to relate significantly to pollution, predation, animal stress and feeding activity. However, there is a need for valvometric techniques applicable to coral reef environments, which may provide critical insights into reef resilience to ocean warming and acidification. Giant clams are endemic to coral reefs and hold great promise as valvometric recorders of light availability, productivity and other environmental variables. Despite this promise, prior valvometric work on giant clams has been limited by specialized hardware less accessible to developing countries where many coral reefs are found. Here we report on an open-source approach that uses off-the-shelf components to monitor smooth giant clam (Tridacna derasa) valve opening behavior, and tests this approach in the simulated reef environment of the Biosphere 2 Ocean. Valvometric data corroborates the influence of light availability on diurnal behavior of giant clams. The clams basked during daylight hours to expose their photosymbionts to light, and adopted a partially-closed defensive posture at night. The animals showed variations in the frequency of complete closures, with most occurring during night-time hours when the animals prioritize filter-feeding activity, clapping their valves to expel pseudofeces from their gills. Closure frequency showed a significant relation to pH and a significant lagged relationship to chlorophyll-a productivity, which are both a function of algal productivity in the Biosphere 2 Ocean tank. These results suggest that the animals fed on phytoplankton following periodic bloom events in the Biosphere 2 Ocean during the experiment. We propose that giant clams exhibit behavioral plasticity between individuals and populations, and advocate for the more widespread use of valvometry to enable comparative studies of reef environment and animal health.
Positive Effect of Parathyroidectomy Compared to Observation on BMD in a Randomized Controlled Trial of Mild Primary Hyperparathyroidism

Mild or asymptomatic disease is now the dominating presentation of primary hyperparathyroidism (PHPT). However, bone involvement with decreased bone mineral density (BMD) and an increased risk of fractures has been demonstrated. Indications for parathyroidectomy (PTX) in mild PHPT have been debated for years. There is a need of long‐term randomized studies comparing PTX with observation without intervention (OBS). Here, we present bone health data from the Scandinavian Investigation of Primary Hyperparathyroidism (SIPH), a randomized controlled trial, comparing PTX to OBS. This study included 191 patients (96 OBS/95 PTX), and 129 patients (64 OBS/65 PTX) were followed for 10 years to the end of study (EOS). BMD was measured with dual‐energy X‐ray absorptiometry (DXA), peripheral fractures were noted, and spine radiographs were obtained for vertebral fracture assessment. There was a significant treatment effect of PTX on BMD compared with OBS for all analyzed compartments, most explicit for the lumbar spine (LS) and femoral neck (FN) (p < 0.001). The mean changes in T‐score from baseline to 10 years were from 0.41 for radius 33% (Rad33) to 0.58 for LS greater in the PTX group than in the OBS group. There was a significant decrease in BMD for all compartments in the OBS group, most pronounced for FN, Rad33, and ultradistal radius (UDR) (p < 0.001). Even though there was a significant treatment effect of PTX compared with OBS, there was only a significant increase in BMD over time for LS (p < 0.001). We found no difference between groups in fracture frequency in the 10‐year cohort, neither with modified intention‐to‐treat (mITT) analysis nor per protocol analysis. Because BMD is only a surrogate endpoint of bone health and PTX did not reduce fracture risk, observation could be considered a safe option for many patients with mild PHPT regarding bone health in a 10‐year perspective. © 2023 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR).
The effect of synbiotic adjunct therapy on clinical and paraclinical outcomes in hospitalized COVID‐19 patients: A randomized placebo‐controlled trial

Therapeutic approaches with immune‐modulatory effects such as probiotics and prebiotics adjuvant therapy may be essential to combat against COVID‐19 pandemic. The present trial aimed to reveal the efficacy of synbiotic supplementation on clinical and paraclinical outcomes of hospitalized COVID‐19 patients. The current randomized placebo‐controlled trial enrolled 78 hospitalized patients with confirmed COVID‐19 infection. Participants were randomly allocated to intervention and control groups that received synbiotic or placebo capsules twice daily for 2 weeks, respectively. The synbiotic capsule contains multi‐strain probiotics such as Lactobacillus (L.) rhamnosus, L. helveticus, L. casei, Bifidobacterium (B.) lactis, L. acidophilus, B. breve, L. bulgaricus, B. longum, L. plantarum, B. bifidum, L. gasseri, and Streptococcus (S.) thermophilus (109 CFU), as well as fructooligosaccharides prebiotic agent. Besides COVID‐19 clinical features, levels of proinflammatory interleukin‐6 (IL‐6), C‐reactive protein (CRP), erythrocyte sedimentation rate (ESR), liver and renal function markers, as well as hematological parameters, were assessed during follow‐up. The serum level of IL‐6 was significantly decreased in the intervention group compared to the placebo after 2 weeks of intervention (p = 0.002). A significant difference was found regarding the count of white blood cells (WBC) within the synbiotic group from pre to post‐treatment (p = 0.004). The levels of ESR (p = 0.935) and CRP (p = 0.952) had a higher reduction trend in the synbiotic group relative to the placebo, with no significant between‐group differences. Other findings had no statistical differences between groups. Our results provide the support that synbiotic adjuvant therapy for 2 weeks can be effective to modulate inflammatory responses against COVID‐19 infection.
Mobile safety cameras: estimating casualty reductions and the demand for secondary healthcare

We consider a fully Bayesian analysis of road casualty data at 56 designated mobile safety camera sites in the Northumbria Police Force area in the UK. It is well documented that regression to the mean (RTM) can exaggerate the effectiveness of road safety measures and, since the 1980s, an empirical Bayes (EB) estimation framework has become the gold standard for separating real treatment effects from those of RTM. In this paper we suggest some diagnostics to check the assumptions underpinning the standard estimation framework. We also show that, relative to a fully Bayesian treatment, the EB method is over-optimistic when quantifying the variability of estimates of casualty frequency. Implementing a fully Bayesian analysis via Markov chain Monte Carlo also provides a more flexible and complete inferential procedure. We assess the sensitivity of estimates of treatment effectiveness, as well as the expected monetary value of prevention owing to the implementation of the safety cameras, to different model specifications, which include the estimation of trend and the construction of informative priors for some parameters.
Involvement of ERCC1 (rs3212986) and ERCC2 (rs1799793, rs13181) polymorphisms of DNA repair genes in breast cancer occurrence in Burkina Faso

Genetic alterations can result in DNA repair defects, increasing susceptibility to breast cancer. The aim of this study was to evaluate the involvement of two DNA repair genes, ERCC1 (rs3212986, GenBank NC_000073.9) and ERCC2 (rs1799793, rs13181, GenBank: NC_000019.10) in the occurrence of breast cancer in Burkina Faso.
Nonlinear, Large Deformation Finite-Element Beam/Column Formulation for the Study of the Human Spine: Investigation of the Role of Muscle on Spine Stability

A nonlinear, large deformation beam/column formulation is used to model the behavior of the human spine under compressive load. The stabilizing roles of muscles are accounted for using Patwardhan’s assumption that muscles act to direct the load along the tangent of the column. Three aspects of the spinal structure are then investigated. First, we look at the effects of two different assumptions for the action of muscles, leading to significant differences in the spine behavior. Second, the difference in mechanical properties between the vertebrae and the spinal disks is explored. Third, a nonlinear mechanical response of the spinal disk that arises from a two-step hierarchical homogenization technique is used. It is found that these factors have an important influence on the overall behavior of the spine structure. The present formulation offers a versatile model to investigate various features of the human spine, while remaining affordable computationally. It also provides an interesting framework for fu.
Electron correlation effects in the dissociative ionization of H2

The dissociative and non-dissociative ionization of H2 by electron impact has been measured up to 1 keV incident energy using a pulsed electron beam and pulsed ion extraction technique in conjunction with a time-of-flight spectrometer and relative flow technique. These data represent the first accurate measurement on the dissociative ionization of H2 by electron impact over such a large energy range. It has been shown that the ratio, R*, of the dissociative ionization cross section to non-dissociative ionization cross section in H2 serves as a useful parameter in probing the electron correlation effects. A comparison of the value of R* obtained by electron impact with those obtained by proton and antiproton impact shows strong dependence on the sign of the projectile charge.
Preliminary data on oxytocin modulation of neural reactivity in women to emotional stimuli of children depending on childhood emotional neglect

Abstract Sensitivity for rewarding cues and distress signals from children is fundamental to human caregiving and modulated by the neuropeptide oxytocin. In a functional magnetic resonance imaging study, we investigated whether oxytocin regulates neural responses to reward or distress cues form children. In a placebo‐controlled, within‐subject design, we measured neural responses to positive, negative, and neutral cues from children in 22 healthy female subjects who received oxytocin (24 IU) versus placebo. Further, based on current literature, we hypothesized that oxytocin effects are modulated by experiences of childhood trauma. The task elicited valence‐specific effects—positive images activated the ventromedial prefrontal cortex, left anterior cingulate cortex, and right putamen, and images of children in distress activated the bilateral amygdala, hippocampus, and right medial superior frontal cortex. The effects of oxytocin depended on subjective reports of childhood emotional neglect. Self‐reported neglect interacted with oxytocin administration in the amygdala, hippocampus, and prefrontal areas. In individuals with higher scores of emotional neglect, oxytocin increased neural reactivity of limbic structures to positive and neutral images. Our findings need replication in larger samples and can therefore be considered preliminary but are in line with the recent literature on the modulating effect of childhood adversity on the sensitivity to oxytocin administration.
Homogeneous material models can overestimate stresses in high tibial osteotomy: A finite element analysis

Although widely used numerical models can assess the stability of lateral hinges in high tibial osteotomy (HTO) and may provide acceptable results in comparative studies, accurate stress prediction may not be possible due to simplified homogeneous models of the bone. The present study aimed to investigate the effect of a heterogeneous versus four homogeneous models on the results of stress and force. Each of the four homogenized FE models utilized the same elastic modulus of 16,700 MPa for the cortical while employing a single elastic modulus varying from 155 to 5000 MPa for the cancellous. In heterogeneous model, the modulus of each element was assigned using the bone density. It was found that stresses at the hinge in homogeneous models were higher than those in the heterogeneous model. The maximum principal stress (MPS) was 437 MPa for the heterogeneous model while that was 2179, 2351, 2581, and 2637 MPa for the homogeneous models with the elastic moduli of 155, 500, 2130, and 5000 MPa, respectively. Also, the opening force was 150 N for the heterogeneous model significantly lower than 649–1534 N range predicted for the homogeneous models. The use of a homogeneous model in the FE analysis of HTO overestimated the stresses and force. Thus, in addition to casting doubt on the use of a single modulus in the numerical analysis of HTO, Future HTO studies can use our results as a benchmark for comparison purposes and highlight the use of patient-specific bone density – elastic modulus relation in simulation.
Exposed – a semantic concept analysis of its origin, meaning change over time and its relevance for caring science

ABSTRACT Purpose A patient is vulnerable and exposed due to illness, relies on and surrender to other people. In caring this means a special dependency. The aim of this study was to describe the origin of the concept ‘exposed’, to elucidate how the definition of this term has changed over time, and to outline its relevance in caring science. Method A semantic concept analysis in two phases was conducted. Results The findings show that over time, the degree of binding of the following synonyms has become stronger; unprotected/defenseless, naked/bare, pressed/jostled and unsafe/unprotected and can easily be transferred to a clinical nursing context. Conclusions This study provides a deeper understanding of the concept 'exposed' semantically. Being exposed is a profound experience for patients who need to be seen as the person they really are. A life-world led care has an existential power that can support professionals, strengthen patients’ health processes, and alleviate the patient’s suffering.
Gamma Oscillations and Potassium Channel Modulation in Schizophrenia: Targeting GABAergic Dysfunction

Impairments in gamma-aminobutyric acid (GABAergic) interneuron function lead to gamma power abnormalities and are thought to underlie symptoms in people with schizophrenia. Voltage-gated potassium 3.1 (Kv3.1) and 3.2 (Kv3.2) channels on GABAergic interneurons are critical to the generation of gamma oscillations suggesting that targeting Kv3.1/3.2 could augment GABAergic function and modulate gamma oscillation generation. Here, we studied the effect of a novel potassium Kv3.1/3.2 channel modulator, AUT00206, on resting state frontal gamma power in people with schizophrenia. We found a significant positive correlation between frontal resting gamma (35–45 Hz) power (n = 22, r = 0.613, P < .002) and positive and negative syndrome scale (PANSS) positive symptom severity. We also found a significant reduction in frontal gamma power (t13 = 3.635, P = .003) from baseline in patients who received AUT00206. This provides initial evidence that the Kv3.1/3.2 potassium channel modulator, AUT00206, may address gamma oscillation abnormalities in schizophrenia.
Comparing infertility-related stress, coping, and quality of life among assisted reproductive technology and non-assisted reproductive technology treatments

Abstract Women who undergo assisted reproductive technology (ART) treatments experience infertility-related stress and have low quality of life (QOL). However, there is limited understanding of infertility-related stress, coping, or QOL among women who undergo non-ART treatments. The purpose of this study was to examine infertility-related stress, coping, and QOL among women who undergo ART and non-ART infertility treatments. Using a descriptive correlational cross-sectional design, we recruited 200 women who underwent infertility treatments. Participants completed the Copenhagen Multi-centre Psychosocial Infertility (COMPI) Fertility Problem Stress Scale, COMPI Coping Styles Scale, Fertility Quality of Life tool, and a demographic infertility survey. Data analysis included descriptive statistics, independent t-test, chi-square, and hierarchical multiple regression. Women who underwent non-ART had more personal stress, used more active-avoidance coping, and had lower emotional, social, and treatment environment QOL compared to those in ART treatment. Women who underwent ART treatments used more meaning-based coping but had lower treatment tolerability QOL. Stress and coping contribute to core QOL differently among infertility treatment groups. Both treatment groups report low satisfaction with emotional services. Regardless of the treatment type, women who undergo infertility treatments may need care to address their psychological health.
Tracking hepcidin level in induced type 2 diabetic rats and how Empagliflozin affects its level.

BACKGROUND Hepcidin is a hormone that contributes to iron homeostasis, produced either through hepatic or extrahepatic pathways. Its production may be affected by proinflammatory mediators released by macrophages, which play a role in the development of peripheral insulin resistance. Insulin itself may increase the production of hepcidin hormone from pancreatic β-cells. OBJECTIVES To evaluate the impact of induction of type 2 diabetes mellitus (T2DM) in albino wister rats on the level of hepcidin. Also, to examine the role of 2-week use of Empagliflozin, a sodium-glucose cotransporter-2 inhibitor (SGLT2 Inhibitor), on the hepcidin level comparing to control. METHOD An interventional study includes randomization of 36 rats into three groups (A: negative control, B: positive control, and C: Empagliflozin group). Two rats were excluded from the study for different reasons. T2DM was induced using high-fat diet/high-sugar diet (HFD/HSD) for 8 weeks. Empagliflozin was then given to Group C for 2 weeks at a dose of 35 mg/kg/day. Hepcidin level was determined at the baseline, and at week 8 and week 10 intervals. Hepcidin was determined using enzyme-linked immunosorbent assay (ELISA). RESULTS Hepcidin level significantly increased following the induction of T2DM in both B and C Groups. Hepcidin level in Group B insignificantly reduced 2 weeks after discontinuation of HFD/HSD and significantly reduced in Group C. Group A experienced no statistical difference in hepcidin level at week 10 when compared to baseline. CONCLUSION Induction of T2DM is associated with a significant increase in the level of hepcidin. Empagliflozin significantly reduced hepcidin level in newly induced diabetic rats.
Features of the Baiu Front Simulated in an AGCM (T42L52).

The simulation studies of the Meiyu-Baiu front, by global climate models, have not been performed in depth. A few experimental studies show insufficient precipitation in the Meiyu-Baiu front, without the detailed analysis on circulation systems in and around the Meiyu-Baiu front. In the present report, we study features of the Meiyu-Baiu front and associated circulation systems simulated in the climatological SST run by the T42L52 model (the maximum zonal wave-number is 42 in triangular wave transformation, and the number of the vertical level is 52) in comparison with the features described in observational studies. The Baiu front is not properly reproduced in the monthly averaged field for June and July. This is due to the alternation of relatively short “Baiu phase” and the longer “non Baiu phase”. In the “Baiu phase”, the large-scale circulation systems, such as the cut-off cyclones and blocking ridge in the northern latitudes, westward extending Pacific Subtropical anticyclone, monsoon westerly, and subtropical jet stream, are properly maintained. Only under this large-scale condition, a realistic Baiu frontal zone is formed in the model. The structure of the Baiu front, the features of precipitation, and the thermal stratification around the frontal zone are reasonably reproduced. In contrast, in the “non Baiu phase”, features in the large-scale field are significantly different from the observed features in the break period, while the continent-ocean thermal contrast is reasonably maintained. Judging from the results, the formation of the Baiu front does not only depend on the direct local effects of physical processes, and continent-ocean thermal contrast, but depends on the maintenance of large-scale environmental circulation systems favorable to sustain the Meiyu-Baiu front.
Satellite observed reversal in trends of spring phenology in the middle‐high latitudes of the Northern Hemisphere during the global warming hiatus

The start of the growing season (SOS) is essential to track the responses of vegetation to climate change. However, recent findings on whether the SOS in the middle‐high latitudes of the Northern Hemisphere (NH) continued to advance or reversed during the global warming hiatus were not consistent. It is necessary to investigate the causes of this controversy and to examine the relationship between the SOS and preseason temperature trends. To this end, we first applied four widely used phenology extraction methods to derive the SOS from the GIMMS NDVI3g dataset and then used the ensemble empirical modal decomposition (EEMD) method to extract the nonlinear trends of the SOS and preseason temperature. Our results clarify, for the first time, that the limitations of the linear assumption‐based trend analysis methods are an important but overlooked cause of the discrepancies among existing studies on whether the SOS was advanced or delayed in the NH (>30° N) during the global warming hiatus. We further revealed the range of the mismatches between the SOS and preseason temperature trends at the latitude, altitude and biome levels. Specifically, we discovered that the SOS in the NH (>30° N) obtained by the four phenology extraction methods showed a significant reversal from advance to delay during the global warming hiatus, and the corresponding average rate of change was very small. The area showing increasing preseason temperatures decreased during the global warming hiatus, but it always occupied most of the NH (>30° N). However, delayed SOS trends were dominant in the NH from 50° N to 60° N, above 3000 m and in biomes other than TBMF and BF. Accordingly, using an EEMD‐like approach to evaluate the changes in the SOS and preseason temperature is necessary for improving our understanding of the changes in the SOS and their association with climate.