Miracle-dz/UniFAR-FTUs huggingface dataset:
tridimensionalidade verbivocovisual da linguagem bakhtiniana

Neste artigo, o intuito e refletir acerca da concepcao de linguagem formulada por Bakhtin, Medviedev e Volochinov, em suas respectivas obras Problemas da Obra de Dostoievski (2010 [1929]), Metodo Formal nos Estudos Literarios (2012 [1928]) e Marxismo e Filosofia da Linguagem (2017 [1929]). O metodo, chamado por Bakhtin (mimeo) de sociologico, considerou o dialogo entre as obras e os autores, em cotejo com outros textos, tanto do Circulo, quanto de estudiosos dessa episteme e ilustrou a reflexao com alguns enunciados esteticos. A hipotese e a que, ao elaborarem e construirem a proposta de estudo sobre e a concepcao de linguagem, os autores russos realizam sua delimitacao conceitual de maneira tridimensional, aqui denominada como verbivocovisual (PAULA, 2017), em vista de conceber o homem constituido pela e na linguagem em sua maxima potencialidade expressiva. Pensar num desdobramento dos estudos bakhtinianos voltado a contemporaneidade revela a relevância desta pesquisa. A contribuicao do estudo consiste na reflexao acerca da pertinencia dos estudos bakhtinianos como fundamentos teoricos para analises de enunciados multimodais, alem da materialidade verbal, extensamente analisada pelos autores russos. Os resultados demonstram que leituras extemporâneas bem fundamentadas podem reacender outras luzes a teoria e, com isso, colaborar com a seara dos estudos bakhtinianos.
Moderated mediating effects of 4-H experience on adolescents’ agricultural career variables

ABSTRACT Purpose Agriculture-related jobs are becoming less attractive to adolescents in South Korea. In this situation, this study aimed to analyze the process of formation of career intention in the agricultural sector in relation to cognitive and emotional variables. In addition, the moderating effects of 4-H experience was analyzed. Design Moderated mediating effect analysis was conducted to the 4-H experience on the relationships between perceived values of agriculture, attachment and career intention. The data were gathered by stratified, cluster and proportional sampling of middle and high school students. A number of 769 questionnaires were used for the analysis after data cleaning. Finding Youths fully perceived the value of agriculture, but they did not have high levels of emotional bonds to agriculture and agricultural career intention. Perceived values of agriculture had a significant positive influence on the formation of agricultural career intention through the mediation of agricultural attachment. 4-H experience had significant moderated effects on the formation of agricultural career intention. Practical implication In terms of the operation of the 4-H program, in order to form agricultural career intention, it is necessary to operate differentiated program according to the youth’s perceptions and attachment level of agriculture. Theoretical implications This study is meaningful in that it identified agricultural career intention through the relationship between cognitive and emotional factor based on behavioral theories. Originality/values This study demonstrates the values of 4-H activities which facilitate the formation of agricultural career intention for youths in a situation where interest in 4-H is diminishing.
Chemical Composition and Antibacterial Activity of the Rhizome and Leaf Oils of Amomum Hypoleucum Thwaites

Abstract Essential oils from the rhizomes and leaves of Amomum hypoleucum were hydrodistilled and characterized by GC/FID and GC/MS. Nineteen constituents comprising 93.0% were identified from the rhizome oil. Cryptone (15.4%), β-pinene (11.9%) and caryophyllene oxide (7.6%) were the major constituents in the rhizome oil. Fifty-two constituents comprising 97.6% were identified from the leaf oil. (E)-Nerolidol (26.5%), α-fenchyl acetate (15.0%) and β-caryophyllene (8.4%) were the major constituents in the leaf oil. These oils showed good antibacterial activity against the Gram-negative bacteria, Pseudomonas aeruginosa, Salmonella typhi and Escherichia coli.
Ionic Conductivity in Solutions of Poly(ethylene oxide) and Lithium Perchlorate

Summary: Solution casting technique served to prepare solid solutions of lithium perchlorate and poly(ethylene oxide) (PEO) having different molecular masses. Salt concentrations of solutions were varied between around 2 and 13 wt%. Crystallinity and melting point depression served to determine composition and content of amorphous phase as well as thermodynamic behavior of the solutions. Conductivity as a function of salt concentration in the amorphous phase follows a power law at constant temperature (30 °C). It results that both exponent and mobility of charge carriers increase with ascending molecular mass of PEO. The mobility follows an increase with molecular mass proportional to M2.8 indicating dependence of mobility on interstitial volume between chain molecules. Deviation of solution from perfect behavior can be evaluated by melting point depression. Accordingly, increase in conductivity is preferably related to approach to perfect solution behavior. Determination of dielectric function allows some conclusion about ion pair formation in the systems under discussion. It turns out that probability of ion pair formation decreases with increasing molecular mass of PEO in agreement with thermodynamic behavior of the solutions.
DFT and TD-DFT Study of Favipiravir Tautomerism as RNA Polymerase Inhibitors : COVID-19

Favipiravir is an antiviral medication currently being trialled as a COVID-19 treatment. To help accelerate these efforts, we have performed a research for tautomers formations of favipiravir as possible RNA polymerase enzyme inhibitors and mitigating the virus ability. This study provides important electronic and optical properties of tautomers determined by density functional theory (DFT) and time-dependent density function theory (TD-DFT) calculations in gas phase and in water. A series of favipiravir derivatives was designed, and study the effect of the HOMO-LUMO energy gap on the efficacy of inhibitors. It has been determined that H-atom positions change and substituting fluorine (F) by hydroxyl (OH) group of tautomers affects the energy gap and dipole moment values. Among all compounds, the results have shown that Fb4 form with OH is most potent inhibitory activity in both gas phase and water. These investigations indicated that these tautomers could be potentially developed into drugs, but further investigations are still required to examine the cytotoxicity and consequent side reactions.
Nucleic Acid G-quartets: Insights into Diverse Patterns and Optical Properties

Structures of various conformers of G-quartets (G4) with different types of hydrogen bonding patterns have been investigated through various levels of Density Functional Theory (DFT). Their structure and stability has been compared with the diad (G2), triad (G3), pentad (G5) and hexad (G6) of guanine. The calculations show that G4 has the highest stabilization through hydrogen-bond interaction which explains the tendency of guanine rich strands in the telomeric region to favor the formation of the quadruplex structure. We have also performed calculations for Li+, Na+, K+, Be2+, Mg2+ and Ca2+ complexes of G4. Calculations show that for an isolated quartet, the metal ion with the smallest ionic radius in their respective groups (IA and IIA) form more stable complexes. Other properties such as the HOMO–LUMO gap and polarizability have also been analyzed. The variation in the polarizability has been studied with respect to the movement of cations along the central cavity of the quartet. Such movement leads to.
Triglyceride to HDL-cholesterol ratio is a predictor of future coronary events: a possible role of high-risk coronary plaques detected by coronary CT angiography

For the prevention of future cardiovascular events, control of residual risks such as triglyceride rich lipoproteins and HDL-cholesterol is an emerging problem beyond LDL-cholesterol. Triglyceride to HDL-cholesterol ratio (TG/HDL ratio) has been reported to be useful for risk classification of cardiovascular diseases. Meanwhile, several studies showed that high-risk plaque characteristics evaluated with coronary CT angiography (cCTA) was associated with the incidence of acute coronary syndrome. However, the relationship of TG/HDL ratio with coronary plaque characteristics and its impact of this association on future coronary events have not been fully elucidated. The aim of this study was to evaluate the association between TG/HDL ratio and high-risk plaque detected by cCTA and its impact on future coronary events. A total of 944 patients suspected stable coronary artery disease who underwent cCTA at our institution were analyzed (mean 64-year-old, 55% male). Patients were divided into two groups by the median value of TG/HDL ratio (higher TG/HDL: TG/HDL ratio ≥2.0, lower TG/HDL: TG/HDL ratio <2.0). Coronary high-risk plaques were defined as a plaque with all three components; low attenuation plaque (<50H.U.), positive remodeling (remodeling index >1.1) and spotty calcification. Cardiovascular event was defined as cardiovascular death, acute coronary syndrome, and late coronary revascularization after 30 days of CT acquisition. The higher TG/HDL ratio was significantly associated with male gender (63% vs. 48%, P<0.001), body mass index (24.8±3.8 vs. 22.9±4.0, p<0.001), the prevalence of hypertension (65% vs. 54%, P<0.001), dyslipidemia (60% vs. 42%, P<0.001), diabetes mellitus (38% vs. 27%, P=0.001) and current smoking (26% vs. 10%, p<0.001). Regarding cCTA findings, the prevalence of significant stenosis, calcified plaque, non-calcified plaque, coronary plaques with low attenuation plaque, positive remodeling and spotty calcification in the higher TG/HDL group were greater than those in the lower group (Figure 1A). Of note, the difference in high-risk plaque between two groups was significant. (18% vs. 11%, p=0.004). Multivariate logistic analysis revealed that the TG/HDL ratio was an independent risk factor for high-risk plaque even after adjustment (OR, 1.35; 95% CI, 1.01–1.81; p=0.049). Regarding coronary events (median follow-up duration; 48 months), Kaplan-Meier curve showed poor event-free rate in the higher TG/HDL group (Figure 1B). At Cox proportional hazard analysis, higher TG/HDL ratio (HR, 1.94; 95% CI, 1.01–3.70; p=0.046) and CT-verified high-risk plaque (HR, 2.36; 95% CI, 1.27–4.38; p=0.006) were independent predictive factors for coronary events even after adjustment. TG/HDL ratio is involved in the vulnerability of CT-verified coronary plaque characteristics. This association may play an important role in the prognostic impact of TG/HDL ratio on future cardiovascular events. Type of funding source: None
Gender stereotypes: the impact upon perceived roles and practice of in-service teachers in physical education

ABSTRACT This study aimed to explore gender stereotypes and their impact upon perceived roles and practice of in-service physical education teachers. Twenty-one qualified PE teachers completed an online story completion method and results were analysed using reflexive thematic analysis. Comparisons were generated between the two-story stems: between male and female participants and between the hypothetical stories and direct question answers. Results showed that teachers’ perceptions largely conformed to typical gender stereotypes, including stereotypical views on gender roles, gendered sports and story character assumptions. Participants did not attribute stereotype reproduction to themselves as teachers and negative external pressures arose as a common reasoning for stereotypical practice. However, only female participants highlighted parents and peers as significant contributors, whereas both genders highlighted governmental pressures such as curriculum design. This study displayed that gender segregation, masculine and feminine discourses and gendered habitus are still prominent within PE.
Mediating Effects of Remuneration on Earnings Management and Firm Equity Value

ABSTRACT This study examines the potential mediating effects of executive remuneration on the relationship between prior-year earnings management and firm equity value. The occurrence of financial scandals in Malaysia has been associated with earnings management, which entails opportunistic manipulation of a firm’s earnings by managers. Managers who are driven by opportunism, engage in earnings management through the manipulation of discretionary accruals (known as accrual-based earnings management method (AEM)) or real activities (known as real earnings management method (REM)) to attain personal wealth maximisation. This is because when executive remuneration is linked to firm performance, managers are incentivised to manage earnings to boost firm performance with the aim to maximise their performance-based remuneration. Thus, through executive remuneration, earnings management may affect firm equity value. However, empirical evidence on the mediating effects of executive remuneration on earnings management and firm equity value is generally scarce. Therefore, using 601 non-financial firms listed on Bursa Malaysia’s Main Market from 2013 to 2017, this study finds significant mediation of executive remuneration on the relationship between both earnings management methods and firm equity value in a different manner. This implies that the mediating effects of executive remuneration lies on the methods of earnings management. This paper, thus, provides insights to financial reporting and corporate governance regulators, and key management personnel of Malaysian public listed firms on the importance of executive remuneration on equity valuation of earnings management. This paper also methodologically contributes to literature by establishing mediation model within the earnings management area. Keywords: Accrual-based earnings management; real earnings management; executive remuneration; firm equity value; mediator; Malaysia
Association of Low Alanine Aminotransferase Values with Extubation Failure in Adult Critically Ill Patients: A Retrospective Cohort Study

Background: Liberation from mechanical ventilation is a cardinal landmark during hospitalization of ventilated patients. Decreased muscle mass and sarcopenia are associated with a high risk of extubation failure. A low level of alanine aminotransferase (ALT) is a known biomarker of sarcopenia. This study aimed to determine whether low levels of ALT are associated with increased risk of extubation failure among critically ill patients. Methods: This was a retrospective single-center cohort study of mechanically ventilated patients undergoing their first extubation. The study’s outcome was extubation failure within 48 h and 7 days. Multivariable logistic and Cox regression were performed to determine whether ALT was an independent predictor of these outcomes. Results: The study included 329 patients with a median age of 62.4 years (IQR 48.1–71.2); 210 (63.8%) patients were at high risk for extubation failure. 66 (20.1%) and 83 (25.2%) failed the extubation attempt after 48 h and 7 days, respectively. Low ALT values were more common among patients requiring reintubation (80.3–61.5% vs. 58.6–58.9%, p < 0.002). Multivariable logistic regression analysis identified ALT as an independent predictor of extubation failure at 48 h and 7 days. ALT ≤ 21 IU/L had an adjusted hazard ratio (HR) of 2.41 (95% CI 1.31–4.42, p < 0.001) for extubation failure at 48 h and ALT ≤ 16 IU/L had adjusted HR of 1.94 (95% CI 1.25–3.02, p < 0.001) for failure after 7 days. Conclusions: Low ALT, an established biomarker of sarcopenia and frailty, is an independent risk factor for extubation failure among hospitalized patients. This simple laboratory parameter can be used as an effective adjunct predictor, along with other weaning parameters, and thereby facilitate the identification of high-risk patients.
Effect of follicular growth promoters on timed artificial insemination in dairy cows.

Objective. To evaluate the efficiency of equine chorionic gonadotropin (eCG) and follicle stimulating hormone (FSH) on the pregnancy rate of crossbred cows from different body condition score (BCS) in the postpartum period in timed artificial insemination (TAI). Material and methods. The cows were subjected to the same hormone protocol: Day zero (D0), progesterone-release intravaginal device (PRID) and 2 mg estradiol benzoate (EB); D8, withdrawal of PRID, application 0.150 mg of prostaglandin. On D8, the animals were distributed into three treatments: 1 – (TeCG; n = 98) injection of 300 IU eCG; 2 – (TFSH; n = 84) injection of 20 mg of FSH and; 3 – (Control; n = 115) without further treatment. On D9, all animals received 1 mg of EB; D10, TAI of all the cows. After 30 days from TAI, ultrasound diagnosis of pregnancy was performed. Results. Pregnancy rate did not differ among eCG (52.04%), FSH (40.47%), and Control (40.00%) treated cows (p>0.05). In cows with low body condition, the pregnancy rate was higher (p<0.05) for cows treated with eCG (41.46%) when compared to FSH (18.18%) and Control (17.07%) cows. The postpartum interval among treatments was similar (p>0.05) (35–65 or 66–95days). Conclusions. The use of eCG or FSH did not result in an increase in the pregnancy rate when compared to the control treatment; however, eCG improved the pregnancy rate of cows with low body condition scores.
Dense Attention Convolutional Network for Image Classification

Convolutional neural networks (CNN) have made rapid progress for a series of visual tasks, but the bottom-up convolutional feature extraction process is not qualified to mimic the human visual perception process, which takes advantages of discriminative features. Although attention modules extract the top-down discriminative features and have been widely investigated in the past few years, current attention modules interrupt the bottom-up convolutional feature extraction process. To tackle this challenge, in this paper, we introduce dense connection structure to fuse discriminative features from attention modules and convolutional features, which we term as dense attention learning. Also, to alleviate the over-fitting problem caused by rapid feature dimension growth, we propose a channel-wise attention module to compress and refine the convolutional features. Based on these strategies, we build a dense attention convolutional neural network (DA-CNN) for visual recognition. Exhaustive experiments on four challenging datasets including CIFAR-10, CIFAR-100, SVHN and ImageNet demonstrate that our DA-CNN outperforms many state-of-the-art methods. Moreover, the effectiveness of our dense attention learning and channel-wise attention module is also validated.
The effects of instructional design based web course on pre-service teachers’ competencies

Web Pedagogical Content Knowledge (WPACK) is an important competence for pre-service teachers in the educational technology course. However, novice pre-service teachers require the preparation stage to integrate the web into instruction. The purpose the study was (a) to develop the new instructional model for pre-service teachers in integrating web and (b) to investigate the effect on pre-service teachers’ competencies compared with the others when applied the model in the course. The PINTARR (Preparation, Isolation, Transformation, Action, Reflection, and Revision) and two other models were implemented in three physics education technology groups with seventy-four participants. The instrument test was constructed to asses the pre-service teachers’ competencies, namely Student analysis, Curriculum organisation, Instructional strategy selection, Evaluation, Technological knowledge, and Physics knowledge. The result of MANOVA showed pre-service teacher in PINTARR group outperformed overall the pre-service teachers’ competencies rather than Multimedia and Web Design Learning group, F (10,132) =13.71, p = . 00, h 2 = . 56. Only on Curriculum organisation, the different of groups was not significantly, F (2,71) = 1.99, p = . 14, h 2 = . 10. The results indicated that the Preparation and the Isolation stage were the most important for novice pre-service teachers in improving the competencies.
Antioxidant and Potentially Anti-Inflammatory Properties in Pasta Fortified with Onion Skin

In recent years, food industries have produced a large volume of waste, which is an ecological and economic problem. Fruit and vegetable by-products can also be promising sources of functional compounds, with documented pro-health potential. The goal of the study was to evaluate the impact of the addition of various concentrations of onion skin powder on the antioxidant and anti-inflammatory properties associated with changes in the quercetin content in uncooked and cooked pastas. The total contents of phenolic acids, quercetin, and antioxidant activity were determined. The anti-inflammatory activity was demonstrated by inhibitory effects on lipoxygenase (LOX) in vitro activity. Dry onion skin is the source of quercetin in analyzed pastas. The concentrations of these compounds gradually and significantly increased with increases in the vegetable component in fortified pastas. Additionally, a positive correlation between the content of phenolic compounds and antioxidant activity of pastas fortified with onion skin powder was noted. The process of cooking caused enhancement in the antioxidant and anti-inflammatory potential. These qualities of pastas resulted from the presence of dry onion skin with high pro-health activities. Fortification of pasta with onion skin powder could be a starting point to benefit onion industrial by-products and produce new healthy food products.
Comparison of management and outcomes of ST-segment elevation myocardial infarction patients in Estonia, Hungary, Norway and Sweden according to national ongoing registries

There is a high need for real-world international comparisons of management of patients with acute myocardial infarction. In Europe Estonia, Hungary, Norway and Sweden are among the few countries with national ongoing acute myocardial infarction registries with a high degree of completeness of data. To compare the management and outcome of hospitalized ST-segment elevation myocardial infarction (STEMI) patients in four European countries with a national ongoing myocardial infarction registry. We compared patient baseline characteristics, use of in-hospital procedures and medications at discharge as well as 30-day and 1-year mortality for all patients admitted with STEMI during 2014–2017 using EMIR (Estonia; n=4,584), HUMIR (Hungary; n=23,685), NOMIR (Norway; n=12,414; data available for years 2013–2016) and SWEDEHEART (Sweden; n=23,342). Country-level results were compared as aggregated data. Mean age ranged from 65 to 69 years (table 1). Estonia and Hungary had compared to Norway and Sweden a higher proportion of women (resp. 39%; 38% vs. 29%; 31%), as well as patients with hypertension (resp. 79%; 72% vs. 39%; 50%), diabetes (resp. 21%; 27% vs. 14%; 19%) and peripheral artery disease (resp. 9% vs. 6%; 4%). Proportion of current smokers was highest in Norway (38%) and lowest in Sweden (27%). Rates of discharge medications were generally high. The results for in-hospital procedures and mortality are shown in table 1. Estonia had the lowest rates of dual antiplatelet treatment (78%) and statins (86%). Norway had the lowest rates of beta-blockers (80%) and angiotensin converting enzyme inhibitors/ angiotensin II receptor blockers (61%). This cross-country comparison of four national European registries provide new insights into differences in risk factors, treatment regiments and outcomes of patients with STEMI. There are several possible reasons for the observed differences, including differences in underlying expected mortality in the populations, inclusion-criteria and coverage of the registries and variable definitions, that need to be further explored. Type of funding source: Public grant(s) – National budget only. Main funding source(s): Estonian Research Council