Miracle-dz/UniFAR-FTUs huggingface dataset:
Immune Response to SARS-CoV-2 mRNA Vaccines in an Open-Label Multicenter Study in Participants with Relapsing Multiple Sclerosis Treated with Ofatumumab

Background: It is unclear whether multiple sclerosis (MS) patients receiving ofatumumab mount an immune response after SARS-CoV-2 mRNA vaccination. Methods: KYRIOS is an ongoing, multicenter, open-label, prospective clinical study on immune responses in MS patients after initial or booster SARS-CoV-2 mRNA vaccination prior to (cohort 1) or during (cohort 2) ofatumumab treatment. We report one-week and one-month results of the initial vaccination. A comparison with patients vaccinated while receiving beta-interferon, glatiramer acetate, dimethyl fumarate, teriflunomide or no treatment was included (cohort 3). Results: In total, 11 patients received their initial vaccination during the study. The primary endpoint of SARS-CoV-2-specific T-cells at month 1 was reached by 80.0% of patients in cohort 1 (N = 6) and 100.0% in cohort 2 (N = 5). T-cell reactivity peaked at week 1. All cohort 1 patients reached seroconversion for SARS-CoV-2 neutralizing antibodies at week 1 and month 1. In cohort 2, neutralizing antibodies increased in all patients and exceeded the cut-off for seropositivity in 40.0% of patients at week 1 and 25.0% at month 1. Immune responses in cohort 3 were comparable to cohort 1. Conclusion: Presence of T-cell response and increase in levels of neutralizing antibodies, although less pronounced compared to controls, suggest that MS patients receiving ofatumumab are able to mount an immune response to SARS-CoV-2 mRNA vaccination.
Radio and white-light observations of the 1973 August 21 coronal transient

A coronal transient, which occurred on 1973 August 21, has been observed simultaneously in white light and at decameter radio wavelengths. The radio observations were obtained with the two-dimensional swept-frequency array (called the Teepee Tee) of the University of Maryland. The white-light observations consist of a series of photographs taken by the High Altitude Observatory's coronagraph abroad Skylab. The radio emission associated with the transient was continuum in nature, and lasted for almost 5 hours. The source of emission was observed to be co-spatial with the lower part of one of the secondary white-light loops. A lower limit of 0.6 R/sub sun/ for the depth (extension along the line of sight) of this part of the transient was derived from considerations of radio-wave propagation in the corona. The radio source showed no dispersion of height with frequency, and therefore we attribute the emission to gyrosynchrotron radiation. Based on this assumption, we estimate the magnetic field strength in the lower part of the loop to be in the 2.0--4.5 gauss range at a height of 2.1 R/sub sun/ from Sun center.
Semiparametric marginal regression analysis for dependent competing risks under an assumed copula

Summary. Competing risks problems arise in many fields of science, where two or more types of event may occur on a subject, but only the event occurring first is observed together with its occurrence time, and other events are censored. The marginal and joint distributions of event times for competing risks cannot be identified from the observed data without assuming the relationship between events. The commonly adopted independent censoring assumption may be easily violated. An alternative is to assume that the joint distribution of event times follows a known copula, which is an explicit function of the marginal distributions. On the basis of the latter assumption, we consider marginal regression analysis for dependent competing risks, with the marginal regressions performed via semiparametric transformation models, including the proportional hazards and proportional odds models. We propose a non‐parametric maximum likelihood analysis, which provides explicit expressions for the score functions and information matrix, and facilitates convenient computations. Large and finite sample properties are studied. We report an illustration with data from an acquired immune deficiency syndrome clinical trial where the censoring may be dependent. The proposal can be readily used as a sensitivity analysis for assessing effects of potential dependent censoring and can incorporate external information on the association of competing risks.
Relationships Between Smartphone Addiction and Personal Qualities and Properties of Belarusians and Russians

: Introduction. Smartphone addiction is the most common non-medical addiction. The purpose of the study is to find common and differences in the relationship between smartphone addiction and personal qualities and properties of Belarusian and Russian men and women ( assertiveness , impulsiveness, narcissism, vulnerability to manipulation, dependence on social networks), comparing the results corresponding to these groups of respondents. Methods. Smartphone addiction diagnosed CAC-16 questionnaire (author V.P. Sheinov), assertiveness - assertiveness test (V.P. Sheinov), vulnerability to manipulation - questionnaire "Assessment of the degree of vulnerability of an individual from manipulative influences" (V.P. Sheinov), dependence on social networks - questionnaire ZSS-15 (V.P. Sheinov, A.S. Devitsyn ) , and impulsivity - by V. BUT. Losenkov , narcissism - questionnaire E. Kot. Results. In the relationship between smartphone dependence and personal qualities and characteristics in the Belarusian (n = 403) and Russian (n = 361) samples of men and women, more similarities were found than differences: smartphone addiction is negatively associated with assertiveness and positively with impulsivity
Unscented Kalman filter and control on TSE(3) with application to spacecraft dynamics

This paper presents a novel rigid-body navigation and control architecture within the framework of special Euclidean group SE(3) and its tangent bundle TSE(3) while considering stochastic processes in the system. The proposed framework combines the orbit-attitude motions of the rigid body into a single, compact set. The stochastic state filter is designedbased on the unscentedKalmanfilter (UKF)which uses a special retraction function to encode the sigma points onto the manifold. The navigation system is then integrated and evaluated with two different control techniques on TSE(3): An almost globally asymptotically stabilizing Morse–Lyapunov-based control system with backstepping and a robust sliding mode-based control sysG. Mangiacapra Politecnico di Torino, Torino 10129, Italy G. Mangiacapra Navigation System Engineer, Northrop Grumman Italia, Pomezia, RM 00040, Italy e-mail: gennaro.mangiacapra@outlook.it M. Wittal · M. Nazari Embry-Riddle Aeronautical University, 1 Aerospace Blvd., Daytona Beach, FL 32114, USA e-mail: nazarim@erau.edu M. Wittal (B) NASA Kennedy Space Center, Merritt Island, FL 32899, USA e-mail: wittalm@my.erau.edu E. Capello Politecnico di Torino, CNR-IEIIT, Corso Duca degli Abruzzi 24, Torino 10129, Italy e-mail: elisa.capello@polito.it tem. Also, the performance of the UKF in TSE(3) proposed here is compared with similar filters in the literature to demonstrate the robustness and accuracy of the proposed filter in a realistic setting. Numerical simulations are conducted to demonstrate the effectiveness of the proposed navigation filter for the full state estimation. In addition, the navigation and control systems are tested in the nonlinear gravity field of a small celestial body with an irregular shape. In particular, the performance of the closed-loop systems is studied in a tracking problem of spacecraft motion near the asteroid Bennu based on OSIRIS-REx mission data.
Tracking and H ∞ control of constrained nonlinear switched systems in strict feedback form

This paper deals withtheproblems of tracking and H ∞ control for output-constrained and state-constrained nonlinear switched systems in strict feedback form. Under a mild condition on the initial output tracking error and the simultaneous domination assumption, a novel approach is proposed to design controller such that the output tracking error converges to zero asymptotically and is always within a pre-speciﬁed limit range. Smooth or p -times differentiable unbounded functions are introduced and incorporated in output tracking error transformations to complete the control design. Furthermore, the developed method is
Investigation of back-illuminated AlGaN avalanche photodiodes with p-type graded Al x Ga 1 − x N layer

The AlGaN avalanche photodiodes (APDs) with a p-type graded AlGaN layer has been designed to investigate the polarization doping effect on the performance of the AlGaN APDs. The calculated results show that the APD with p-type graded AlGaN layer exhibits lower avalanche breakdown voltage and increased maximum multiplication gain compared with the conventional structures. The improved performances of the designed APDs are due to the polarization-assisted enhancement of the ionization electric ﬁeld at the point of maximum multiplication gain. The spectral responsivity and distribution of electric ﬁeld for the speciﬁc APDs are investigated numerically to explain the superior performances.
Robust sampled-data H∞ control for offshore platforms subject to irregular wave forces and actuator saturation

This paper presents a robust sampled-data H∞ control scheme for vibration attenuation of offshore platforms subject to irregular wave forces and actuator saturation. When a digital computer is used to sample and quantize the measurement signal, a discrete-time control input signal will be produced. At the same time, the actuator is usually saturated due to the physical or technological constraints. In view of these, a sampled-data H∞ controller is designed to attenuate the wave-induced vibration of the offshore platform, thereby improving the control performance of the system. It is shown through simulation results that the proposed control scheme is effective to suppress the vibration of the offshore platform in the presence of actuator saturation.
Numerical determination of concentration-dependent Auger recombination coefﬁcient in n -InGaN alloys

Direct and phonon-assisted mechanisms of Auger recombination in bulk n - In x Ga 1 − x N wurtzite alloys are numerically investigated. The matrix elements of electron– electron and electron–phonon interaction are calculated using the band structure and wave functions obtained by the empirical pseudopotential method. Phonon-assisted Auger process is analyzed by the spectral density functions approach. The dependences of Auger recombination coefﬁcient on the energy band gap of n -In x Ga 1 − x N alloys, temperature and carrier concentration are presented. The calculated Auger coefﬁcients for alloys corresponding to the visible spectrum exhibit strong reduction at high carrier concentration.
Joint optimization of source, mask, and pupil in optical lithography

Mask topography effects need to be taken into consideration for more advanced resolution enhancement techniques in optical lithography. However, rigorous 3D mask model achieves high accuracy at a large computational cost. This work develops a combined source, mask and pupil optimization (SMPO) approach by taking advantage of the fact that pupil phase manipulation is capable of partially compensating for mask topography effects. We first design the pupil wavefront function by incorporating primary and secondary spherical aberration through the coefficients of the Zernike polynomials, and achieve optimal source-mask pair under the condition of aberrated pupil. Evaluations against conventional source mask optimization (SMO) without incorporating pupil aberrations show that SMPO provides improved performance in terms of pattern fidelity and process window sizes.
On the layers produced by rapidly oscillating a vertical grid in a uniformly stratified fluid

Experiments have been made to examine the fluid motion and density perturbations caused by oscillating a grid of vertical bars horizontally in a uniformly stratified fluid at frequency ω greatly exceeding the buoyancy frequency N. A highly turbulent region is produced near the grid. Beyond this lies a region of intrusive layers as described by Ivey & Corcos (1982), while further from the grid the motion is dominated by internal waves. The boundary between the turbulent region and the intrusive region is clearly defined, and the width of the former region appears to be proportional to $y = a^{\frac{3}{4}}M^{\frac{1}{4}}(\omega/N)^{\frac{1}{2}}$, where a is the amplitude and M the mesh length of the grid. The vertical scale of the layers, which sometimes form to give a regular sequence of high and low density gradients, is also proportional to y. This scaling is shown to be consistent with that found by Hopfinger & Toly (1976) in their study of motion produced by grids oscillating in homogeneous fluids, while the abrupt change in character of the motion at the edge of the turbulent region is in accord with measurements made by Dickey & Mellor (1980) in the wake of a grid drawn steadily through a stratified fluid. The scaling is also in accord with Ivey & Corcos’ observations of the width of the turbulent region, the thickness of the layers, and the vertical flux of density. The observation of the layers is considered in the light of conjectures about the instability of turbulent motion in stratified fluids. The character and conditions of generation of the layers are consistent with their being a manifestation of the instability, but the identification is not conclusive.
Slow Motion of a Small Sphere in a Cylindrical Domain

A general study is made on the slow motion of a viscous incompressible fluid bounded by cylindrical boundaries. The solution of the Stokes equations of motion is reduced essentially to a simple boundary value problem for three harmonic functions. The correction factor to the force on a small sphere moving in a plane perpendicular to the axis of a circular tube is determined to the first order effect of the boundary. A striking result is that in the vicinity of the axis the force is less than that due to the axial motion.
Fluorine Abundances in AGB Carbon Stars: New Results?

Abstract A recent reanalysis of the fluorine abundance in three Galactic Asymptotic Giant Branch (AGB) carbon stars (TX Psc, AQ Sgr and R Scl) by Abia et al. (2009) results in estimates of fluorine abundances systematically lower by ∼0.8 dex on average, with respect to the sole previous estimates by Jorissen, Smith & Lambert (1992). The new F abundances are in better agreement with the predictions of full-network stellar models of low-mass (<3 M⊙) AGB stars.
Exponential and polynomial stability of an elastic Bresse system with two locally distributed feedbacks

In this paper, we study the energy decay rate for the elastic Bresse system in one-dimensional bounded domain. The physical system consists of three wave equations. The two wave equations about the rotation angle and the longitudinal displacement are damped by two locally distributed feedbacks at the neighborhood of the boundary. Then indirect damping is applied to the equation for the transverse displacement of the beam through the coupling terms. We will establish the exponential stability for this system in the case of the same speed of propagation in the equation for the vertical displacement and the equation for the rotation angle of the system. When the wave speeds are different, nonexponential decay rate is proved and a polynomial-type decay rate is obtained. The frequency domain method and the multiplier technique are applied.
A Study of Suicide Risk Using a Cox Cure Model via a Retrospective Sampling and Multiple Imputation

The incidence of suicide is an example of rare event. A Cox cure model is adopted to examine the suicide risk of a cohort study of a sample of 65,000 Personal Emergency Link users over a 10-year observation period. Our objective is to investigate the effect of personal covariates on the failure time to suicide as well as the long-term survival from suicide. Based on the Cox cure model, a new and efficient estimation approach using retrospective sampling and multiple imputation was used. Compared with the standard Cox proportional hazards model, the Cox cure model provides a new perspective on analyzing the suicide data.
A search for radio emission associated with the 1978 november 19 gamma-ray burster.

VLA maps of the field of the gamma-ray transient of 1978 November 19 show a number of radio sources, some of which are candidates for association with the gamma-ray source. The two strongest, linearly polarized (3%) sources may be the outer double of a Sco X-1--like triple radio source, whose central source is inside the error region of the gamma-ray transient. These three radio sources, and a fourth weak source inside the error region for the location of the gamma-ray source, are not coincident with any optical image on ESO prints. The locations of these four radio sources deserve further searches for the time variability, proper motion, more Sco-1--like characteristics, or association with weak X-ray sources or very faint stars.
Preemptive Repeat Priority Queues as a Special Case of the Multipurpose Server Problem—I

In this part of the study it is assumed that the servicing rate of the station is constant and the variability of service time is caused by the differing service requirements of the customers. Some characteristics of the model, such as the expected queue length and queuing time are derived. The effect of the type of service time variability upon the expected queue length is illustrated by a numerical example. The preemptive repeat priority problem, analogous to this model, is solved as a special case. Some other special cases are discussed in the paper.
Viscous Slip Along Grain Boundaries and Diffusion of Zinc in Alpha‐Brass

The viscous behavior of the grain boundaries in 70–30 alpha‐brass was demonstrated by anelastic measurements. It was shown that the grain boundaries cannot sustain permanently a shear stress and have a coefficient of viscosity decreasing with an increase of temperature. Using the same alpha‐brass specimen, the activation energy associated with the stress‐induced preferential orientation of pairs of zinc atoms in alpha‐brass (which is a diffusion process) was determined. This activation energy was found to be identical, within experimental error, to the activation energy associated with the grain boundary slip in alpha‐brass. This finding indicates that the grain boundary slip in alpha‐brass is a diffusion process and the diffusion mechanism is similar to the volume diffusion in alpha‐brass.
Treatment Success and associated factors among patients with Pulmonary Tuberculosis attending Kampala Capital City Authority health facilities: A retrospective cohort study

Background TB treatment success remains low in Uganda at 82%, below the recommended WHO target ([≥]90%). Consequences of poor treatment outcome include; increased MDR-TB prevalence, treatment costs and death. Kampala Capital City Authority (KCCA) public health facilities are congested which compromises the care given to pulmonary tuberculosis patients (PTB) that affects the treatment success of patients. However, there is scarce information regarding factors that are associated with treatment success among PTB patients in KCCA public health facilities. General Objective To determine the treatment success and associated factors among patients with pulmonary tuberculosis attending KCCA public health facilities in Kampala between July 2019 and June 2020. Methods A retrospective cohort study that involved review of records for 772 PTB patients who were enrolled on TB treatment in five KCCA health facilities from July 2019 to June 2020. Data on socio-demographic and clinical factors was abstracted from health facility TB registers. Data was entered in epidata and analyzed using STATA_v14 software. A modified poison regression model with robust standard errors was used in analysis and risk ratios were reported. Results Treatment success was 87.2% (CI: 84.2%-89.1%), PTB patients who cured accounted for 413 (53.5%) and 260 (33.7%) completed treatment. Factors associated with PTB treatment success were: being classified as a clinically diagnosed PTB patients (aRR= 0.8, CI: 0.53 - 0.94, P value =0.021) and having a positive HIV/AIDS status (aRR= 0.7, CI: 0.43 - 0.88, P value =0.006) reduced treatment success and having a community volunteer as a treatment supporter was associated with increased treatment success (aRR= 1.2, CI: 1.06 - 3.28, P value =0.028). Conclusion Over 80% of PTB patients in KCCA public health facilities achieve treatment success although this is still below the WHO target. Factors associated with TB treatment success include; being classified as a clinically diagnosed PTB patient, having a positive HIV/AIDS status as factors that reduce treatment success and having a community volunteer as a treatment supporter improves treatment success. Efforts such as consistent follow-ups should be encouraged among clinically diagnosed and HIV/AIDS positive PTB patients. Additionally, community volunteers should be empowered to support PTB patients.
The microbiome shifts throughout the gastrointestinal tract of Bradford cattle in the Pampa biome

A deep understanding of the cattle gastrointestinal microbiome is crucial to selective breeding high-efficiency animals that produce more and generate less environmental damage. Here we performed the taxonomic identification of Bacterial and Archaeal communities using high throughput 16SrRNA gene sequencing from critical compartments of the gastrointestinal tract of Bradford cattle raised in a natural grassland in the Pampa biome, Brazil. We analyzed 110 samples, including saliva, ruminal fluid, and feces from 36 months old Bradford heifers (weighing on average 343 ± 30 kg by the sampling time). To reduce unexpected variation and confounders, we selected the animals from the same breed, submitted them to the same food source, and collected the samples for three consecutive years from different animals in the same season. Our main goal was to analyze the microbial shifts throughout the gastrointestinal tract to reference future works proposing management strategies and interventions to improve animal nutrition and increase production in the Pampa Biome. To accomplish our objective, we accessed the microbial community differences in groups with a high and low weight gain controlling for food ingestion and quality of grazed pasture. Few taxa were shared among the samples. About 40% of the phyla and 60% of the genera were unique from saliva samples, and 12.4% of the microbial genera were uniquely found in feces. All samples shared only 36.1% of phyla and 7.5% of genera. Differences in microbial diversity and taxa counts were observed. The ruminal fluid presented the lowest microbial richness, while saliva and feces presented the highest microbial richness. On the other hand, saliva and feces also presented more distinct communities between themselves when compared with ruminal samples. Our data showed that the saliva microbiome is not representative of the rumen microbiome and should not be used as an easy-to-collect sample for studies about the rumen microbiome.
On the Smoothing Property of the Galerkin Method for Parabolic Equations

We analyze the Galerkin approximation of the general second-order parabolic initial-boundary value problem. For the second-order continuous time method with initial data only in $L^2 $ we prove an $L^2 $ error estimate of order $O({{h^2 } / t})$. Analogous results are shown to hold for the error in negative Sobolev norms and for the time derivative of the error. Our analysis uses only elementary energy techniques and the same techniques are shown to give a simple analysis of the backward Euler time discretization.