Miracle-dz/UniFAR-FTUs huggingface dataset:
DNA Polymerase zeta is a major determinant of resistance to platinum-based chemotherapeutic agents

Oxaliplatin, satraplatin, and picoplatin are cisplatin analogs that interact with DNA forming intrastrand and interstrand DNA crosslinks (ICLs). Replicative bypass of cisplatin DNA adducts requires the cooperative actions of at least three translesion DNA synthesis (TLS) polymerases: eta (Pol η ), REV1, and zeta (Pol ζ ). Because oxaliplatin, satraplatin, and picoplatin contain bulker chemical groups attached to the platinum core as compared to cisplatin, we hypothesized that these chemical additions may impede replicative bypass by TLS polymerases and reduce tolerance to platinum-containing adducts. We examined multiple responses of cancer cells to oxaliplatin, satraplatin, or picoplatin treatment under conditions where expression of a TLS polymerase was limited. Our studies revealed that although Pol η contributes to the tolerance of cisplatin adducts, it plays a lesser role in promoting replication through oxaliplatin, satraplatin, and picoplatin adducts. REV1 and Pol ζ were necessary for tolerance to all four platinum analogs and prevention of hyper-activation of the DNA damage response following treatment. In addition, REV1 and Pol ζ were important for the resolution of DNA double-stranded breaks (DSBs) created during replication-associated repair of platinum-containing ICLs. Consistent with ICLs being the predominant cytotoxic lesion, depletion of REV1 or Pol ζ rendered two different model cell systems extremely sensitive to all four drugs, whereas Pol η depletion had little effect. Together, our data suggest that REV1 and Pol ζ are critical for promoting resistance to all four clinically relevant platinum-based drugs by promoting both translesion DNA synthesis and DNA repair.
Scenario Classification

A scenario-based testing approach can reduce the time required to obtain statistically significant evidence of the safety of Automated Driving Systems (ADS). Identifying these scenarios in an automated manner is a challenging task. Most methods on scenario classification do not work for complex scenarios with diverse environments (high-ways, urban) and interaction with other traffic agents. This is mirrored in their approaches which model an individual vehicle in relation to its environment, but neglect the interaction between multiple vehicles (e.g. cut-ins, stationary lead vehicle). Furthermore, existing datasets lack diversity and do not have per-frame annotations to accurately learn the start and end time of a scenario. We propose a method for complex traffic scenario classification that is able to model the interaction of a vehicle with the environment, as well as other agents. We use Graph Convolutional Networks to model spatial and temporal aspects of these scenarios. Expanding the nuScenes and Ar-goverse 2 driving datasets, we introduce a scenario-labeled dataset, which covers different driving environments and is annotated per frame. Training our method on this dataset, we present a promising baseline for future research on per-frame complex scenario classification.
E�cacy of CPP-ACP GC Tooth Mousse in remineralization of teeth of Syrian orphan Children-results of a double -blind, randomized controlled clinical trial

Objectives A double-blind randomized controlled clinical trial was undertaken to evaluate the e�cacy of Casein Phosphopeptide-Amorphous Calcium Phosphate (CPP-ACP) in the remineralization of teeth of Syrian children aged 6-8 years enrolled in orphanage of the city of Damascus. Materials and Methods The study sample included 50 children randomly divided into two treatment groups to receive either CPP-ACP GC Tooth Mousse™ (Group A) or placebo (Group B) with 25 participants per group. After the application of the product in the mouth for 3 minutes, saliva samples were collected four time (T0, T1, T2, and T3) to measure the pH of saliva and the rate of salivary �ow. Results There was no signi�cant difference between group A and B in the mean value of salivary �ow rate and salivary pH. However, there was signi�cant difference between different time points in the mean value of salivary pH and salivary �ow rate.
Ground motion scaling in the Marmara region, Turkey

SUMMARY Predictive relationships for the ground motion in the Marmara region (northwestern Turkey) are parametrized after regressing three-component waveforms from regional earthquakes, in the frequency range: 0.4‐15.0 Hz, and in the distance range: 10‐200 km. The data set consists of 2400 three-component recordings from 462 earthquakes, recorded at 53 stations. Moment magnitudes, M w, range between 2.5 and 7.2. The largest event for which we have waveforms available (M w 7.2) occurred in Duzce on 1999 November 12. The aftershocks of that earthquake, together with the aftershocks of the 1999 August 17 Izmit event (M w = 7.4), are included in the dataset. Regressions are performed, independently, on Fourier velocity spectra and on peak ground velocities, for a large number of sampling frequencies. A simple model is used to relate the logarithm of the measured ground motion to excitation, site, and propagation terms. Results obtained for peak velocities are used to define a piecewise continuous geometrical spreading function, g(r), a frequency-dependent Q(f ), and a distance-dependent duration function. The latter is used, through random vibration theory (RVT), in order to predict time-domain characteristics (i.e. peak values) of the ground motion. The complete model obtained for the peak ground motion was used to match the results of the regressions on the Fourier amplitudes. Fourier velocity spectra for the combined horizontal motion are best fit by a hinged quadrilinear geometrical spreading function for observations in the 10‐200 km hypocentral distance ranges as a function of frequency: f 100, f ≥ 1.0 Hz, r −1.0 for r ≤ 30 km; r −0.6 for 30 100 km. The frequency-dependent crustal shearwave quality factor Q (f ) coefficient Q( f ) = 180 f 0.45 . The T (5‐75 per cent) duration window provides good agreement between observed and predicted peak values. By modelling the behaviour of the small earthquakes at high frequency, we also quantified a regional parameter κ = 0.055 s. Spectral models with one single-corner frequency (Brune), and with two-corner frequencies (Atkinson and Silva) fit the observed high-frequency excitation levels equally well, whereas the model by Atkinson and Silva fits the low-frequency observations slightly better than Brune’s. RVT is used to predict the absolute levels of ground shaking, following Boore’s implementation of the stochastic ground motion model (Boore’s SMSIM codes). Our regional empirical predictive relationships are compared to the ones adopted in several regions of the world, from California to Western United States.
Tuning Up the Old Brain with New Tricks: Attention Training via Tuning Up the Old Brain with New Tricks: Attention Training via Neurofeedback Neurofeedback

Neurofeedback (NF) is a form of biofeedback that uses real-time (RT) modulation of brain activity to enhance brain function and behavioral performance. Recent advances in Brain-Computer Interfaces (BCI) and cognitive training (CT) have provided new tools and evidence that NF improves cognitive functions, such as attention and working memory (WM), beyond what is provided by traditional CT. More published studies have demonstrated the efﬁcacy of NF, particularly for treating attention deﬁcit hyperactivity disorder (ADHD) in children. In contrast, there have been fewer studies done in older adults with or without cognitive impairment, with some notable exceptions. The focus of this review is to summarize current success in RT NF training of older brains aiming to match those of younger brains during attention/WM tasks. We also outline potential future advances in RT brainwave-based NF for improving attention training in older populations. The rapid growth in wireless recording of brain activity, machine learning classiﬁcation and brain network analysis provides new tools for combating cognitive decline and brain aging in older adults. We optimistically conclude that NF, combined with new neuro-markers (event-related potentials and connectivity) and traditional features, promises to provide new hope for brain and CT in the growing older population.
Effects of Ultra-Porous 3D Printed Reefs on Wave Kinematics

ABSTRACT Frau, L. ; Marzeddu, A. ; Dini, E; Gracia, V. ; Gironella, X. ; Erioli A. ; Zomparelli, A. , and Sánchez-Arcilla, A. , 2016. Effects of ultra-porous 3D printed reefs on wave kinematics. In: Vila-Concejo, A. ; Bruce, E. ; Kennedy, D.M. , and McCarroll, R.J. (eds.), Proceedings of the 14th International Coastal Symposium (Sydney, Australia). Journal of Coastal Research, Special Issue, No. 75, pp. 851–855. Coconut Creek (Florida), ISSN 0749-0208. Present 3D printing technology allows the efficient design and construction of structures with complex shapes and high porosity satisfying biological and coastal protection demands. In this case, an array of ultra-porous tetrahedron-shaped 3D printed artificial reef (UPTSAR) is proposed to be used as a submerged breakwater for both environmental enhancement and wave protection. The aim of this study is to analyse the wave-structure interaction effects and the resulting velocity and wave height fields. For this, two-dimensional small scale tests (1:15) using irregular waves were carried out in a wave flume facility at BarcelonaTech. The influence of wave steepness, relative freeboard, relative water depth and the porosity on wave Kinematics have been analysed. The paper will describe in detail the results obtained for the different tests. These results are used to evaluate the functionality of the UPTSAR as coastal protection structures.
Minimum Wage Effects on Hours, Employment and Number of Firms: the Iowa Case

programming and analyzing this data set. Kelly Cordaro and Norma Meade did the telephone survey and key entry work. Donna Otto prepared the manuscript. and Number of Firms: The Iowa Case Research on Iowa low-wage retail and service industries supports the long-standing view that minimum wages lower employment opportunities for workers. The sample period includes three successive changes in the Iowa minimum wage in 1990, 1991, and 1992, during which time the Iowa rate exceeded the federal minimum wage and that of its surrounding states. Firm level longitudinal data which separated sub-from superminimum workers yielded employment demand elasticities ranging from-0.3 to-0.7. Hours elasticities were even larger, implying that the increases in minimum wages lowered earnings for subminimum workers. These findings are corroborated by analysis of county-level two-digit industry data. Minimum wages also reduced the number of firms, but increased average firm size in these industries.
Strong eddy compensation for the Gulf Stream heat transport

Using a high‐resolution ocean model forced with high‐resolution atmospheric fields, a 5 year mean heat budget of the upper ocean in the Gulf Stream (GS) region is analyzed. The heat brought to the region with the mean flows along the GS path is 2–3 times larger than the heat loss to the atmosphere, with the difference being balanced by a strong cooling effect due to lateral eddy heat fluxes. However, over a broad area off the Grand Banks, the eddies warm the uppermost ocean layers, partly compensating for the loss of heat to the atmosphere. The upward eddy heat flux, which brings heat from the deeper ocean to the upper layers, is 30–80% of the surface heat loss.
Intensive Storm Water Monitoring for Metals in the B-Street/Broadway Piers and Downtown Anchorage Drainage Areas of San Diego, CA

In this study intensive storm water monitoring was conducted for 22 metals (total and dissolved concentrations) for urban drainage areas in San Diego, CA (B Street/Broadway Piers and Downtown Anchorage) for the period of 2009-2010. Key findings from this monitoring program are presented. Storm water samples were collected during both dry weather periods and wet weather events, and for both sediment and water, at a number of sites (37 dry, 6 wet) across the drainage areas. Wet weather sampling used both pollutagraph and flow-weighted composite sampling to characterize pollutant concentrations during storm events. The land use monitoring sites provide bases for modeling and storm water characterization among different land uses. The results suggested that concentrations of dissolved copper and zinc were elevated compared to hardness-corrected California Toxic Rule (CTR) water quality objectives for both the study areas. Urban and industrial areas were the contributors of total copper and zinc, as suggested by higher concentrations from industrial land use sites. The wet weather sampling suggests there is a relationship between total metals concentrations and flow during storm events but not for dissolved metals. The transport of metals (total concentrations) is facilitated by total suspended sediments (TSS). Estimated daily dry weather loads for a number of metals were greater than wet weather loads, suggesting that dry weather loads can be significant. This study represents one of the most comprehensive efforts at characterizing storm water quality in an urban area.
U–Pb zircon geochronology in the western part of the Rayner Complex, East Antarctica

– Pb zircon geochronology was applied to nine metasedimentary samples collected from Mt. Yuzhnaya, Condon Hills, and Mt. Lira in the inland region of the Rayner Complex of western Enderby Land, East Antarctica, in order to de ﬁ ne the eastern limits of the western Rayner Complex that underwent the Pan – African metamorphism and to evaluate potential source areas of metasedimentary rocks. Condon Hills and Mt. Lira revealed metamorphic ages of ~ 894 and ~ 934 Ma, respectively, which are consistent with previously reported metamorphism in association with Rayner Structural Episode (RSE). Mt. Yuzhnaya samples affected by the RSE contain zircon grains rejuvenated during 590 – 570 Ma, which indicates that the Pan – African reworking can be extended up to Mt. Yuzhnaya. On the other hand, the Condon Hills samples include Archean detritus, and the age peaks from 3850 to 2491 Ma are the oldest components in the Rayner Complex of western Enderby Land. There is no evidence of reworked Napier Complex rocks in the studied Rayner samples.
The impact of sexuality in advertisements on consumers purchase behaviour: A social media perspective

In every corner of our daily life the appearance of advertisements has a significant impact in our purchase decisions. Further on that the sexual aspects are playing an even bigger role while is not only that shape the customer’s purchase behaviour. This paper purpose is to analyse the impact of the sexual content of advertisements has on both genders and further to identify the effect on their purchase decision. In other words, this study aimed to explore the real attitudes of the consumers when they are exposed in advertisements with sex appeals. This study followed the qualitative method and participated 12 people took part, 6 male and 6 female respondents. The research was in the form of tape recorded interviews. The outcome of the analysis that has emerged showing that the influence on the sex appeals to the customer purchase behaviour was not the one that used to be. The customers emphasize now on the product and make their purchases in conscious. However, everyone agreed that the sexual appeal in adverts still sells. It used to, and it will continue to do it. Especially in the field of Social media and digital marketing.
GENDER INCLUSION IN TVET INSTITUTIONS: A REVIEW OF POLICY IMPLEMENTATION IN KENYAN TECHNICAL INSTITUTES

Gender inclusion is acknowledging that everyone deserves to be treated with respect regardless of gender identity and expression and ensuring that systems and processes treat all genders equally. It entails doing everything possible to ensure that systems and processes treat all genders with both horizontal and vertical equity in access to education. Inclusive education is about quality, equal participation and safety to learn without fear of discrimination or violence. Sustainable Development Goal 5 encourages all Technical and Vocational Education and Training (TVET) institutions to domesticate the model policy to their specific and contextual needs and mandates to intentionally and collectively mainstream gender across policy decisions, systems, operations, infrastructure, curricular and training and job placements. While enrolment in TVET institutions in Kenya has increased, a report by Republic of Kenya still indicates that there is persistent gender disparity in access especially in enrollment to given courses and study areas in TVET institutions. Kenya Vision 2030 also views gender as a key developmental challenge facing the country. This paper sought to establish the use of gender inclusion policy in access to TVET institutions. The study was guided by capabilities approach theory developed by Amartya Sen and human rights approach highlighting the common principles of participation, accountability, non-discrimination and equality, empowerment and legality (PANEL). The findings may help TVET institutions evaluate their practice of gender inclusion policy, identify gaps in their operations and take necessary actions.
RELACIÓN DEL FEED-BACK POSITIVO Y EL MIEDO A FALLAR SOBRE LA MOTIVACIÓN INTRÍNSECA

ABSTRACT The aim of this study was to determine the predictive relationship of positive feedback received by the student and the fear of failure in relation to intrinsic motivation using, as mediating variables, motivational orientation and psychological need. The Performance Failure Assessment Inventory (PFAI) was validated in the context of physical education. The sample consisted of 654 physical education students with an average age of 15. The Spanish versions of the perception of teacher feedback scale (PTF) were administered, as were the long and short versions of the Performance Failure Assessment Inventory (PFAI), the Achievement Goals Scale 2 x 2 and the Satisfaction of Basic Psychological Needs Scale, and the intrinsic motivation factor of the Perceived Locus of Causality Scale (PLOC) was used. A descriptive analysis and correlation of all variables was performed, and to test the predictive relationship between the proposed variables, a measurement model and a structural equation model were performed. The results confirmed the reliability and factor structure of the PFAI scale and showed that intrinsic motivation was positively predicted by psychological mediators, along with the motivational orientations and these, in turn, by positive feedback and negatively by fear of failure. The mediator relationship with others was the exception, with no correlation. Due to the novelty of the proposal, further studies are needed in this field to substantiate the results obtained.
QURAN RECITER IDENTIFICATION: TECHNIQUES AND CHALLENGES

Speech-based intelligent systems are gaining an increasing popularity and importance due to their wide range of applications in our daily life. Most of the research efforts within speaker identification target the English language. However, efforts that target the Arabic language and the holy Quran are still limited. For Muslims, the Holy Quran is the main religious book of Islam. The Holy Quran verses must be read according to very restricted rules known as “Tajweed’ to guarantee the correct pronunciation of verses. The task of identifying the holy Quran reciter or reader based on many features in the corresponding acoustic wave is known as Quranic reciter identification process. It is considered a more challenging task than other speaker identification tasks as it depends on “Tajweed”. As a result, this paper provides a survey of the Holy Quran reciter identification problem, describing the proposed techniques, models and challenges in this area, focusing on the advances made during the last decade to help future researchers who aim to enhance previous results.
STOCKS FORECASTING EXPLORATION ON LQ45 INDEX USING ARIMA(p,d,q) MODEL

Up to now, there are 700 stocks listed on the Indonesia Stock Exchange (IDX). An example of an index listed on the IDX is the LQ45 stock index. LQ45 index contains 45 stocks, and these stocks are grouped because of their high liquidity, large market capitalization, and good company fundamentals. Since this index is a fundamental reference index for passive investors, it is necessary to model the prediction of LQ45 stocks to predict these stocks' movement accurately. One form of modeling used is the ARIMA (p, d, q) model. In this study, ARIMA (p, d, q) modeling was conducted to predict the price of 45 stocks in LQ45. The ARIMA (p, d, q) model is a time series model that is suitable for modeling LQ45 stocks because it is only based on the relationship with previous data (AR), and the resulting error is assumed to be related to the previous error (MA). The problem that arises is that the movement of shares can be seen from the visual image (plot), while the function of the movement is unknown. This modeling is expected to help observe the ARIMA functional form of each LQ45 stock and measure the Mean Absolute Percentage Error (MAPE) of each stock. ARIMA (p, d, q) consists of AR(p) and MA(q) models as well as combining d differencing processes. ARIMA (p, d, q) modeling briefly contains several processing stages: parameter estimation, residual test, and prediction. This study showed that the mean forecast error using MAPE for LQ45 stock was 10.088%, with a standard deviation of 8.968%. Furthermore, BBCA stocks had the lowest forecast error of 2.1797%, and MDKA stocks had 44.49%. The highest forecast error was due to MDKA stocks having visually and exponentially increased. Therefore, it can continue increasing exponentially or even decreasing sharply in the future price period.
children: radiologic evaluation. Resective surgery for intractable epilepsy in

Epilepsy surgery is gaining popularity for the treatment of children with intractable seizures in whom either a focal or extensive unilateral structural brain lesion is demon strated. We evaluated the pre-and postoperative imaging findings in 29 patients (aged 22 days to 19 years) who underwent hemispherectomies, 12 total and 17 subtotal. Pathologic correlation was obtained in all cases. Preoperatively, positron emission tomography and electroencephalography demonstrated abnormalities in all of the 28 children studied, but frequently could not characterize the lesion. CT or MR or both demonstrated focal or unilateral lesions in only 19 of these but gave additional infor mation regarding the nature of the lesion. Preoperative angiographic findings were abnormal in five of 17 patients studied and were particularly useful in the evaluation of the extent of abnormality in patients with Sturge-Weber syndrome. Postoperatively, CT and MR demonstrated early complications such as the development of epidural blood and fluid collections, parenchymal hemorrhage, infection, and early hydrocephalus. Postoperatively, MR demonstrated the early development of septations, the presence of subarachnoid hemorrhage, andfor the deposition of hemosiderin in four patients, findings that historically have been associated with the development of devastating clinical complications. From these data, a recommended protocol of radiologic evaluation for patients undergoing hemispherectomy has been established.
Unemployment as a Social Norm in Germany

This paper investigates the relationship between the subjective well-being of both the employed and unemployed and regional unemployment rates. While employed men suffer from regional unemployment, unemployed men are significantly less negatively affected. This is consistent with a social-norm effect of unemployment in Germany. We find no evidence of such an offsetting effect for women.