Miracle-dz/UniFAR-FTUs huggingface dataset:
Trastuzumab associated cardiac adverse effects in breast cancer

Trastuzumab has been used widely for the treatment of women with human epidermal growth factor receptor-2(HER2) overexpressing breast cancer in the early and advanced disease.However,cardiac toxicity has emerged as a rare but potentially serious risk that limits its therapeutic potential in a subset of women.Asymptomatic decreasing left ventricular ejection fraction(LVEF) was a common complication and generally reversible and manageable.The increasing risk of trastuzumab-induced cardiac toxicity may be influenced by factors such as age,hypertension and the use of anthracyclines-based chemotherapy.Rigorous cardiac monitoring should be performed for all patients receiving trastuzumab currently in clinic.
Comparative Study of the Clinical Outcome of Retrograde Laparoscopic Appendicectomy Using a Single Polymer Clip for Complicated Versus for Non-Complicated Appendicitis

Objective To evaluate the clinical outcome of using single Hem-O-Lock polymer clip and compare technical feasibility of retrograde laparoscopic appendicectomy for complicated versus non-complicated appendicitis in adults. Methods A single institute prospective study of 78 patients presenting with acute appendicitis, Only 60 patients were eligible, 3 port retrograde laparoscopic appendicectomy were used in both groups and a single Hem-O-Lock polymer clip applied to secure the appendicular stump. The primary clinical outcome was the severity of pain at 1-7 days. Secondary outcomes included the duration of operation (minutes), procedure-related complications, conversion rates and length of hospital stay. Results Four patients (15.4%) were converted to open surgery, three in group I and one patient in group II. Four patients developed postoperative complications, three in group I and one patient in group II. Operative time was less in Group II. The difference in conversion rates and post-operative complication between two groups is statisticallynot significant with a P value> 0.05. Conclusion Retrograde laparoscopic appendicectomy using single polymer clip make easy access operating complicated as well as non-complicated appendicitis.
Analysis on Clinical Pathological Data of 5000 Cases Undergoing Renal Biopsy in a Hospital in Xi'an

Objective To understand the constitution of pathological types and its relation with clinical types in kidney disease patients taken percutaneous renal biopsy. Methods The 5 000 cases of renal biopsy from patients with kidney disease during January 1981 and March 2007 in a hospital in Xi'an were selected. Pathological classifications were made according to the WHO criteria of 1982 for renal pathology, the modified WHO criteria of 1995 and the modified China criteria of 2001, their clinical data, laboratory results, immunopathological and ultrastructural pathological results were diagnosed and analyzed by a panel of pathologists and nephrologists. Results The mean age of patients at renal biopsy was 35.5±11.4 (4~86) years and the ratio of male to female was 1.95:1. Primary glomerular diseases accounted for 77.40% of the total renal biopsies, secondary glomerular diseases accounted for 19.44%. Mesangial proliferative lesion ( 42.14%) was the most frequent patholigic type of primary glomerular diseases, followed by IgA nephropathy (26.18%). The most frequent type of secondary glomerular diseases was lupus nephritis (33.74%), followed by Henoch-Schonlein purpura glomerulonephritis (32.20%) and hepatitis B virus associated nephritis (7.86%). Conclusion Our dates show that renal diseases in this hospital often happened in young men. Primary glomerular disease is the most common renal glomerular disease and mesangial proliferative lesion is the most common histological types, followed by IgA nephropathy. Lupus nephritis, followed by henoch-Schonlein purpura glomerulonephritis, are the most common types of the Secondary glomerular diseases.
Postoperative PTH Measurement as a Predictor of Hypocalcaemia after Thyroidectomy

Abstract Background: Hypocalcaemia after thyroidectomy is the most common postoperative complication, with a reported incidence from 0.5% to even 50% of the operated patients. Hypoparathyroidism could be a result of careless or inadequate preparation during the surgical procedure. There is a variety of proposed options for the prediction of the incidence of hypocalcaemia. The most effective of them are the peri-operative and intra-operative measurements of the parathyroid hormone (PTH) level. Methods: A prospective study was performed on 100 patients who underwent total thyroidectomy from January 2007 to June 2008. The total calcium level and intact human PTH (iPTH) levels were measured 24 hours before as well as 1 hour and 24 hours after the surgery. The aim: The goal of the study was to assess the potential correlation between the iPTH levels after the operation and the development of hypocalcaemia. The possible prediction value of postoperative iPTH levels was to be assessed. Results: We have presented a significant correlation between early iPTH measurement and the risk of hypocalcaemia. Moreover, a significant correlation between the iPTH level one hour after operation with the calcium level 24 hours after the operation was demonstrated. Conclusion: Early postoperative assessment of iPTH levels can be used to identify the group of patients at risk of hypocalcaemia after thyroidectomy. Pre-emptive calcium supplementation can lead to the avoidance of complications causing prolonged hospital stay and most importantly to prevent severe hypocalcaemia.
Interpersonal Trust Scores of College Students and Their Parents.

The relationship of parentZ' trust of others to their college children's trust was investigated by the use of the Interpersonal Trust Scale. 100 male and 100 female college students, whose scores were , SD above or below the mean of a larger group, were selected. Parents of these students were sent the same questionnaire and a high rate of return (67 percent) was obtained. Fathers appear to exert a significant influence on the attitudes of their sons, but have little effect on daughters. Mothers' scores show a weak statistical trend toward a small and equal effect on sons and daughters. Belief in interpersonal communications is a basic characteristic of a healthy society. Recently, dramatic attention has been brought to an alleged "credibility gap" regarding many of the statements about foreign affairs which spokesmen for government make and to the increasing evidence that the Negro has little faith in the promises of government officials on all levels. There may be an equally strong but less dramatic reduction in trust in general public reaction toward doctors, teachers, repairmen, and others. The need for studies of the development and maintenance of attitudes of trust or distrust is evident. The area of interpersonal trust is being viewed from the perspective of social learning theory (Rotter, 1954). According to this orientation, choice behavior in specific situations depends upon the expectancy that a given behavior will lead to a particular outcome or reinforcement in that situation and the preference value of that reinforcement for the
Covert Spatial Orienting in Audition: Exogenous and Endogenous Mechanisms

Covert orienting in hearing was examined by presenting auditory spatial cues prior to an auditory target, requiring either a choice or detection response. Targets and cues appeared on the left or right of Ss' midline. Localization of the target in orthogonal directions (up vs. down or front vs. back, independent of target side) was faster when cue and target appeared on the same rather than opposite sides. This benefit was larger and more durable when the cue predicted target side. These effects cannot reflect criterion shifts, suggesting that covert orienting enhances auditory localization. Fine frequency discriminations also benefited from predictive spatial cues, although uninformative cues only affected spatial discriminations. No cuing effects were observed in a detection task
Proliferative Glomerulopathy with Unusual Subendothelial Deposits of Striated Structure in Multiple Myeloma

A 50-year-old woman was admitted for the evaluation of proteinuria and renal biopsy. On the basis of the serum monoclonal protein, marrow plasma cell dyscrasia and end organ damage (nephrotic range proteinuria), multiple myeloma was diagnosed. A renal biopsy showed a membranoproliferative glomerulonephritis pattern of injury and unusual organized deposits of striated structure in the subendothelial space, which were identified as non-amyloid non-immunoglobulin-derived deposits. These deposits contained regularly stacked straight electron-dense bands, which have not been described in the setting of paraproteinemia and/or plasma cell dyscrasia.
The association of HIV-1 and other sexually transmitted diseases, and its relevance to intervention programmes in rural Uganda : a simulation modelling exercise.

Since the heterosexual transmission of HIV may be enhanced in the presence of other sexually transmitted diseases (STDs), high STD prevalences in some African populations may contribute substantially to the HIV epidemic, but the magnitude of this effect is uncertain. A stochastic simulation model, SimulAIDS, was extended, and used to simulate the transmission dynamics of HIV infection and of ulcerative and non-ulcerative STDs in an attempt to mirror the development of the HIV epidemic in a rural population cohort of 10,000 under study by the MRC Programme on AIDS in Uganda. Three scenarios were compared, assuming different STD cofactor effects. Simulation results were most consistent with empirical data for a scenario that assumed enhancing effects on HIV transmission per sexual contact of 100 for ulcerative STDs and S for non-ulcerative STDs in females. A scenario assuming no STD cofactor effects was not consistent with results from the study population. By sampling from the simulated population, it was possible to assess the influence of various factors on associations between HIV and other STDs in observational studies. The most important included type of study design, choice of study sample, prevalence of STDs, misclassification of STDs, period over which STD history is recorded, and sexual behaviour characteristics. Further simulations were conducted to estimate the fraction of HIV infections in this population attributable to the cofactor effect o f STDs, and to assess the relative effectiveness of differing intervention strategies. Results were consistent with STDs playing a critical role in establishing an HIV epidemic, their role decreasing as the epidemic progresses. Reducing the incidence of HIV infection in short-term sexual partnerships, through improved STD treatment, increased condom use, and a reduction in one-off sexual encounters, was found to have a substantial impact on HIV incidence in the general population.
Clinical Observation of Diacerein Combined with Duhuo Jisheng Decoction in Treatment of Middle-old People with Knee Osteoarthritis

Objective:To approach the curative effect and safety of Diacerein combined with Duhuo Jisheng decoction in the treatment of knee osteoarthritis.Method:One hundred and twenty patients with knee osteoarthritis were selected,which were divided into Duhuo Jisheng decoction group(group A),Diacerein group(group B) and combination group(group C) randomLy.Every group was handled with the appropriate treatment.One month was a course,and totally with observation and treatment of three month.The VAS score,WOMAC score,ESR and CRP were the indicators of clinical efficacy,and the comprehensive efficacy score was evaluated.Result: After the treatment for three months,the VAS score,WOMAC score,erythrocyte sedimentation rate(ESR)and C-reactive protein(CRP) were improved significantly than before(P0.01). The indicators of clinical efficacy in group C were better the group B and C(P0.05),the comprehensive efficacy score were also best(P0.01),and with a lower rate of adverse events(7.5%). Conclusion: Diacerein and Duhuo Jisheng decoction were effective drugs for treatment of the knee osteoarthritis;the clinical efficacy was more significant when combined together,and with no obvious adverse events.It is worth promoting.
Development and Preliminary Validation of the Workplace Diversity Climate Scale

THE DEVELOPMENT AND PRELIMINARY VALIDATION OF THE WORKPLACE DIVERSITY CLIMATE SCALE Nouran Sakr Advisor: University of Guelph, 2019 Dr. Leanne S. Son Hing Diversity climate captures employees’ subjective experiences of their diversity-related work context. However, the diversity climate literature highlights past inconsistencies in its conceptualization and challenges in its operationalization. The present research aims to develop and validate a new scale for workplace diversity climate based on a novel conceptual framework. Across five studies, we adhered to current best practices to create a new scale of diversity climate and provide initial evidence of its construct validity. Studies 1, 2, and 3 provided evidence that the scale items were in line with our proposed definition and distinguishable from related constructs. Studies 4 and 5 investigated the scale’s factor structure and provided evidence of its internal consistency. Study 5 further provided evidence of the robustness of the scale’s factor structure across historically marginalized and nonmarginalized employees. Together, the present set of studies gave rise to the 16-item Workplace Diversity Climate Scale.
Two-Dimensional Breath-Hold Coronary MR Angiography in Normal Adults

Purpose: To assess the efficacy of two-dimensional breath-hold coronary magnetic resonance angiography (coronary MRA) in normal rolunteers. Materials and Methods: During a four-month period, 11 volunteers underwent MRA of the major coronary branches using a 2-D multiphase breath-hold spiral fast-gradient echo sequence. The proximal diameter of each visualized coronary artery was measured, and visibility and image quality were also determined. Results: Adequate visualization was achieved in 82-100% of proximal coronary arterial branches and in 36-55% of the middle, distal branches. In general, the diameter of the proximal coronary artery correlated closely with that measured from conventional coronary angiography and using previous coronary MRA data. However, visibility and image quality in the left circumflex coronary artery were limited. Conclusion: In the majority of subjects, 2-D coronary MRA provides adequate visualization of the proximal segments of the major coronary arterial branches.
Adding fuel to the fire

Cancer Antioxidant drugs used to treat cancer can cause undesirable side effects. Diabetic patients are at increased risk of developing cancer, and Wang et al. show that drugs with antioxidant properties used to treat diabetes all accelerated metastasis in mouse models of cancer. Although not yet tested in human patients, it might be prudent to exercise caution when prescribing these types of drugs to patients with an increased risk of developing cancer. Sci. Transl. Med. 8 , 334ra51 (2016).
Analysis on Epidemiological Characteristics and Control Measures of Measles in China During 2004-2006

Objective In order to know measles epidemiological characteristics in China during 2004-2006 and provide evidence for strategies and measures of measles prevention and control. Methods Analyzing measles epidemiology and control measures with descriptive epidemiology.Results The reported measles incidence rate of China was 9.05/100000 in 2005.The incidence rate in 2006 is lower than that of the same period of 2005.The measles incidence rate is higher in western provinces in 2004,and higher in eastern and eastern-northern provinces in 2005.The proportions of measles cases aged 0-14 years old in 2004,2005,and 2006 are 83.90%,70.33% and 66.81% respectively,which shows a decreasing trend.But the proportions of measles cases aged 0-1 year old are increased from 4.54 in 2004 to 21.15 in 2006.37% of all cases are floating population in the whole China in 2005 and the proportions are over 50% in some developed provinces and big cities.The incidences decline remarkably in Xinjiang and Guizhou Provinces after measles vaccination campaign.Conclusions Routine vaccination should be strengthened to prevent and control measles.Provinces with high incidence rate of measles should conduct measles vaccination campaign at suitable time.According to measles epidemiological characteristics in China,the application studies on measles prevention and control should be conducted.
A multidisciplinary approach to sediment provenance analysis of the late Silurian–Devonian Lower Old Red Sandstone succession, northern Midland Valley Basin, Scotland

Sediment provenance analysis is important in reconstructing chronological and spatial relationships between source area erosion/exhumation and sediment deposition in adjacent basins. Here we provide new provenance data from conglomerate clast populations, sandstone petrography, heavy mineral assemblages and U–Pb detrital zircon geochronology from the 9 km-thick, Siluro-Devonian Lower Old Red Sandstone (LORS), northern Midland Valley Basin (MVB), Scotland. The MVB developed in the foreland to the Caledonian Orogeny and comprises a mixed succession of conglomerate and pebbly sandstone interbedded with volcanic lithologies. Analysis of 554 samples (137 petrographical thin sections across 22 formations/members; 390 conglomerate clast recordings across 7 locations; 17 heavy mineral and 10 detrital zircon samples) from the entire succession shows a proximal, consistent source or sources located to the east or NE. These results indicate that sediment derived directly from areas of Scandian uplift of Norwegian lithologies is unlikely to have made a significant contribution to the LORS of the northern MVB and the provenance instead lies more proximally in both the neighbouring Dalradian Supergroup metasedimentary rocks and other contemporaneous lithologies. The coarse-grained nature of the sedimentary rocks suggests consistent and continued uplift of these lithologies throughout deposition of the LORS. Integration of these provenance techniques allows robust interpretation of basin fill from a tectonically rejuvenating source in the Caledonian foreland. Supplementary material: MVB LORS palaeocurrent data; List of sample locations is available at https://doi.org/10.6084/m9.figshare. c.4661966
Cambro-Ordovician anatexis and magmatic recycling at the thinned Gondwana margin: new constraints from the Kouřim Unit, Bohemian Massif

The Kouřim Unit represents one of the largest pre-Variscan meta-igneous complexes in the Bohemian Massif and a geochronological, whole-rock geochemical and Sr–Nd isotopic study was conducted to better understand the magmatic evolution of the Early Paleozoic Gondwana margin. Five orthogneisses yield U–Pb zircon ages ranging from 492 ± 4 to 484 ± 2 Ma. Two leucogranites give U–Pb zircon ages of 500 ± 4 and 485 ± 2 Ma, interpreted to be inherited from their orthogneiss host rock. Two samples from the metasedimentary host rock are dominated by Neoproterozoic–Cambrian detrital zircons. The abundance of zircon inheritance in the orthogneisses and whole-rock Sr–Nd isotopic composition imply an origin from relatively mature continental crustal material. The subalkaline, subaluminous–slightly peraluminous and high-K calc-alkaline arc-like geochemical signature of the orthogneisses is interpreted as inherited from the recycled Cadomian metasedimentary source and both the magmatic and metasedimentary rocks are correlated with similar occurrences in the adjacent Moldanubicum and Teplá–Barrandian Unit. The Late Cambrian–Early Ordovician magmatic activity is linked to crustal anatexis, which was probably initiated by thermal and gravitational relaxation of the thickened Cadomian arc-type crust, followed by lithospheric thinning assisted by far-field forces. The extensional event led to the formation of a passive margin associated with the opening of the Rheic Ocean. Supplementary material: Analytical methods, petrographic descriptions with photographs of studied samples, collections of CL images of representative zircon grains, results of LA-ICP-MS U–Pb analyses of zircons and an additional geochemical diagram are available at https://doi.org/10.6084/m9.figshare. c.4649255
Playground and Garden Physical Activity Levels in Young Children

The purpose of this study was to determine the differences in time spent in physical activity (PA), as assessed by the amount of time spent in PA, vector magnitude (counts/15 sec.), MET values, and energy expenditure (kcal/min), between two outdoor environments (natural playground and garden) in preschool children. Participants were twenty-five children (4.4±0.7 years) enrolled in a university laboratory preschool. PA was assessed using an ActiGraph GT3X+ accelerometer that was worn on the right hip. Each child completed four randomly ordered conditions (30 min each), which included two bouts of unstructured PA on the natural playground and two bouts of semistructured PA in the garden. Accelerometer data were classified as minutes in sedentary behavior and total PA combining varying intensities (light, moderate, and vigorous). Data were averaged to make one 30 min bout for each environment. Paired Samples T-Tests were conducted to look at differences in PA, vector magnitude, corrected metabolic equivalents (METS), and energy expenditure between the two environments. On average, the children spent 17.7 min/half hour in total PA on the playground and 15.0 min/half hour in total PA in the garden with no significant differences in PA (p=0.053), or sedentary time (p=0.052). The playground had a higher average vector magnitude compared to the garden (793.4±209.6 vs.635.9±191.5 counts/15 sec.; p<0.05), corrected MET level (2.9±0.6 vs. 2.5±0.4 ml/kg/min; p<0.05), as well as energy expenditure (1.8±0.5 vs. 1.5±0.3 kcal/min; p<0.05). Overall, the
Evaluation and Analysis of Temperature-Dependent Dynamic $R_{{{\mathrm{DS}}},{{\mathrm{ON}}}}$ of GaN Power Devices Considering High-Frequency Operation

Commercial enhancement-mode gallium nitride (GaN) HEMTs device is a superior candidate for high-frequency power electronics applications. However, GaN power devices have a unique dynamic <inline-formula> <tex-math notation="LaTeX">${R}_{{\mathrm{\scriptscriptstyle DS},\mathrm{\scriptscriptstyle ON}}}$ </tex-math></inline-formula> problem which increases the conduction loss of the converter during operation. In this article, the temperature-dependent dynamic <inline-formula> <tex-math notation="LaTeX">${R}_{{\mathrm{\scriptscriptstyle DS},\mathrm{\scriptscriptstyle ON}}}$ </tex-math></inline-formula> at high frequency is evaluated experimentally for the first time using the double-pulse test (DPT) and multiple-pulse test (MPT) techniques. Different temperature-dependent dynamic <inline-formula> <tex-math notation="LaTeX">${R}_{{\mathrm{\scriptscriptstyle DS},\mathrm{\scriptscriptstyle ON}}}$ </tex-math></inline-formula> characteristics between the DPT and the MPT at high temperatures are investigated. The significance of the dynamic <inline-formula> <tex-math notation="LaTeX">${R}_{{\mathrm{\scriptscriptstyle DS},\mathrm{\scriptscriptstyle ON}}}$ </tex-math></inline-formula>’s temperature dependence is important since GaN devices are typically operating at elevated temperatures. The results suggest that the traditional wafer-level test method using one pulse or two pulses and the MPT without heating consideration or at lower pulse frequency may not be sufficient to evaluate the dynamic <inline-formula> <tex-math notation="LaTeX">${R}_{\mathrm{\scriptscriptstyle DS},\mathrm{\scriptscriptstyle ON}}$ </tex-math></inline-formula> effect. Combined with high-frequency, high-voltage, and high-current stress, high operating temperatures result in severe <inline-formula> <tex-math notation="LaTeX">${R}_{\mathrm{\scriptscriptstyle DS},\mathrm{\scriptscriptstyle ON}}$ </tex-math></inline-formula> degradation; hence, there is a diminished return on operating the devices at high temperatures.