Miracle-dz/UniFAR-FTUs huggingface dataset:
The expression of VEGF and cyclin D1/EGFR in common primary liver carcinomas in Egypt: an immunohistochemical study

Background: The most common types of primary malignant liver tumours are hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA). Treatment options for patients who are inoperable/advanced, or recurring are challenging. Cyclin D1, epidermal growth factor (EGFR) and vascular endothelial growth factor (VEGR) are common carcinogenic proteins that have potential therapeutic targets in various cancers. They have been implicated in the development of HCC and CCA. In this study, we aimed to evaluate the oncogenic function expression of cyclin D1, EGFR and VEGF in HCC and CCA of Egyptian patients. This could help to validate their therapeutic potential. Material and methods: Tumour cases were selected from 82 cases of primary liver carcinomas, with 58 cases being from HCC and 24 cases from CCA compared to 51 non-tumour adjacent liver cases and 18 from normal liver tissue. The immunohistochemical study of cyclin D1, EGFR and VEGR was conducted. Results: Cyclin D1, EGFR and VEGF are overexpressed in HCC and CCA as compared to the control group (p < 0.001). Cyclin D1 was related to well-differentiated grade and early pathologic stage in HCC (p = 0.016 and p = 0.042, respectively). The well-differentiated grade showed significantly higher VEGF levels (p = 0.04). In the CCA group, however, EGFR was strongly related to high tumour size (p = 0.047). EGFR and VEGF were overexpressed in HCC raised in the non-cirrhotic liver compared to those developed in post-hepatitic liver cirrhosis (p = 0.003 and p = 0.014). Conclusion: Cyclin D1, EGFR and VEGF shared significant overexpression in HCC and CCA. EGFR and VEGF may play an oncogenic function in the development of HCC in non-cirrhotic liver. Furthermore, cyclin D1 and VEGF may play a good prognostic function in HCC, but EGFR may play a bad prognostic role in CCA.
Further characteristics of positive radiation fields from lightning in sweden

Characteristics of the fields radiated by lightning in Sweden have been reported recently by Cooray and Lundquist (1982). That study is supplemented here by presenting additional characteristics of those fields that are hypothesized to be produced by positive return strokes. The new data presented here indicate that the currents in the sources of these radiation fields are either similar in duration to the currents in negative return strokes or of longer duration. This is based on the observation that the duration of these radiation fields are either similar to that of negative return strokes or of longer duration. During the first 50–100 μs both normal and long-duration waveforms, and hence the inferred currents, seem to behave in a similar manner. That is, there is an initial peak in the first few tens of microseconds and then a decay. After this the field and the inferred currents in some positive strokes continue to decay and in others start to increase again and reach a second peak in a few hundred microseconds. While the current is flowing, in some cases, a burst of electromagnetic pulses with a separation between pulses of about 3 μs or less occur. The shape of the inferred long-duration currents are similar to the shapes of the positive return stroke currents measured in lightning strikes to high towers.
ENGINEERING STUDIES ON DRYING TOMATOES (ESSOLANUM LYCOPERCUM) LEATHERS USING INFRARED AND HOT AIR

: This study was carried out at Rice Mechanization Center (RMC) in Meet Eldeebah village, Agricultural Research center,Dokki,Giza,,Egypt, during 2021 to study the possibility of utilization the infrared radiation and hot air for drying tomato leathers at two different levels of infra-red radiation intensity (1000 and 900 W/m 2 ), two different levels of drying air temperature (55 and 60°C), drying air velocity (0.5m/sec) and thickness of (0.8 cm). The experimental work included the use of the simple exponential Lewis model for describing the drying behavior and predicting the changes in moisture content of tomato leathers during the drying process. The obtained results showed that the drying rate increases with increasing temperature and infrared radiation. The highest value recorded at 60 °C and 1000W/m 2 and reached 0.620155 (gw/gd.hr). The optimum treatment that achieved the highest quality of tomato leathers at radiation intensity of 1000W/m 2 , air temperature of 60°C, also the same treat-ment recorded the Less drying time (9 hours).
Early and Middle Proterozoic evolution of Yukon

This paper provides a comprehensive synthesis of virtually all units and events of Early and Middle Protero- zoic age in the Yukon, spanning 1 Ga. Early and Middle Proterozoic time was dominated by a series of extensional- basin-forming events punctuated by orogenesis, magmatism, and hydrothermal activity. Basinal deposits include the Wernecke Supergroup (>1.71 Ga), Pinguicula Group (1.38 Ga), and Mackenzie Mountains Supergroup (1.00-0.78 Ga). Igneous rocks include the Bonnet Plume River Intrusions (1.71 Ga), Slab volcanics (≥1.6 Ga), Hart River sills and volcanics (1.38 Ga), and Bear River (Mackenzie) dykes (1.27 Ga). A voluminous hydrothermal event generated the widespread Wernecke breccias at 1.60 Ga. The Racklan orogeny deformed the Wernecke Supergroup prior to emplace- ment of the Wernecke Breccia. The Corn Creek orogeny deformed Mackenzie Mountains Supergroup and older rocks prior to deposition of the Windermere Supergroup (<0.78 Ga). Long intervals with scanty rock records extended for as much as 300 Ma and appear to represent periods of crustal stability and subaerial conditions. By the time of Windermere rifting (<0.78 Ga), the supracrust of northwestern Laurentia was a mature, largely denuded orogenic belt with a composite sedimentary-metamorphic-igneous character. New isotopic data include Nd depleted mantle model ages for the Wernecke Supergroup (2.28-2.69 Ga) and Wernecke Breccia (2.36-2.96 Ga), a U-Pb zircon age for a Hart River sill13819 37 53 . − + (Ma), detrital U-Pb zircon ages from the basal Pinguicula Group (1841-3078 Ma), detrital musco- vite ages from the Mackenzie Mountains Supergroup (1037-2473 Ma), and muscovite 40 Ar/ 39 Ar cooling ages from the
Towards a Transparent and an Environmental-Friendly Approach for Short Text Topic Detection: A Comparison of Methods for Performance, Transparency, and Carbon Footprint

—Online social media platforms have contributed significantly to the dissemination of user-generated information. Many studies have proposed various techniques to analyze publicly available short texts to automatically extract topics. The majority of these works have mainly focused on the competitive performance of the proposed approaches. In this paper, our main focus is on how to tackle this problem by incorporating two other important qualities: Transparency and Carbon Footprint. These two pillars are cornerstones to fulfill the emerging international demands and to adhere to the new regulations, such as “Right to Explanation” and “Green AI”. Based on these three qualities, this paper compares the most prominent algorithms in this field ( specifically within the category of unsupervised-retrospective learning), such as: Latent Dirichlet Allocation, Non-Negative Matrix Factorization, and K-Means, as well as two most recent approaches, such as: BERTopic and Contextual Analysis. By using two different datasets, the methods were evaluated for Performance. On average, the results show that BERTopic is the best-performing approach overall in terms of Performance. However, Contextual Analysis achieves the best Performance in one of the two datasets used. When considering the three qualities together, the results demonstrate the effectiveness and the benefits of the Contextual Analysis method towards a more transparent and greener approach for the topic detection task.
Extracellular Vesicles and Their Renin–Angiotensin Cargo as a Link between Metabolic Syndrome and Parkinson’s Disease

Several studies showed an association between metabolic syndrome (MetS) and Parkinson’s disease (PD). The linking mechanisms remain unclear. MetS promotes low-grade peripheral oxidative stress and inflammation and dysregulation of the adipose renin–angiotensin system (RAS). Interestingly, brain RAS dysregulation is involved in the progression of dopaminergic degeneration and PD. Circulating extracellular vesicles (EVs) from MetS fat tissue can cross the brain–blood barrier and may act as linking signals. We isolated and characterized EVs from MetS and control rats and analyzed their mRNA and protein cargo using RT-PCR and the ExoView R200 platform, respectively. Furthermore, cultures of the N27 dopaminergic cell line and the C6 astrocytic cell line were treated with EVs from MetS rats. EVs were highly increased in MetS rat serum, which was inhibited by treatment of the rats with the angiotensin type-1-receptor blocker candesartan. Furthermore, EVs from MetS rats showed increased pro-oxidative/pro-inflammatory and decreased anti-oxidative/anti-inflammatory RAS components, which were inhibited in candesartan-treated MetS rats. In cultures, EVs from MetS rats increased N27 cell death and modulated C6 cell function, upregulating markers of neuroinflammation and oxidative stress, which were inhibited by the pre-treatment of cultures with candesartan. The results from rat models suggest EVs and their RAS cargo as a mechanism linking Mets and PD.
Stress interaction between seismic and volcanic activity at Mt Etna

SUMMARY Mt Etna lies on the footwall of a large normal fault system, which cuts the eastern coast of Sicily and crosses the volcano eastern flank. These faults are responsible for both large magnitude historical earthquakes and smaller damaging seismic events, closer to the volcano. We investigate here the two-way mechanical coupling between such normal faults and Mt Etna through elastic stress transfer. The comparison between eruptive sequences and historical seismicity reveals that the large earthquakes which struck the eastern Sicily occurred after long periods of activity along the Mt Etna rift zone. The larger the erupted lava volumes, the stronger the earthquake. The smaller earthquakes located on the eastern flank of the volcano occur during periods of rift zone eruptions. We point out that the seismicity rates are well correlated with the rate of erupted lava. By modelling elastic stress changes caused by earthquakes and eruptions in a 3-D elastic half-space, we investigate their interaction. Earthquake dislocations create a vertical stress gradient along fissures oriented perpendicular to the minimum compressive stress and compress shallow reservoirs beneath the volcano. This may perturb the magmatic overpressures in the Etna plumbing system and influence the transport and storage of the magma as well as the style of the eruptions. Conversely, the large rift zone eruptions increase up to several tenths MPa the Coulomb stress along the eastern Sicily normal fault system and may promote earthquakes. We show that the seismic activity of the normal faults that cut the eastern flank of the volcano is likely to be controlled by Coulomb stress perturbations caused by the voiding of shallow reservoirs during flank eruptions.
Intergroup Contact Is Associated with Less Negative Attitude toward Women Managers: The Bolstering Effect of Social Dominance Orientation

This cross-sectional study examined the intergroup contact hypothesis in the workplace by enrolling 150 Italian employees. Within the framework of social dominance theory, the purpose of this study was to test the assumption that individuals with higher levels of social dominance orientation are more likely to exhibit prejudice against women in managerial positions and benefit more from intergroup contact with a female supervisor. In particular, we found that individuals with higher levels of social dominance orientation exhibited more negative attitudes towards women in manager positions, but this effect only appeared when their superiors were women, as opposed to men. In addition, participants with higher social dominance orientation experienced more positive outcomes from intergroup contact, resulting in less negative attitudes toward women managers, than those with lower social dominance orientation. Overall, these findings yield insights into how intergroup contact affects individuals with prejudice tendencies, indicating that contact with the targeted group (i.e., women in managerial positions) is negatively associated with negative attitudes towards the group, even when the prejudice is driven by social dominance orientation. These results could shed light on new routes to design practical intervention aimed at solving prejudice towards women in leadership roles.
The Pathophysiology of Gilles de la Tourette Syndrome: Changes in Saccade Performance by Low-Dose L-Dopa and Dopamine Receptor Blockers

Aim: To elucidate the pathophysiology of Gilles de la Tourette syndrome (GTS), which is associated with prior use of dopamine receptor antagonists (blockers) and treatment by L-Dopa, through saccade performance. Method: In 226 male GTS patients (5–14 years), we followed vocal and motor tics and obsessive–compulsive disorder (OCD) after discontinuing blockers at the first visit starting with low-dose L-Dopa. We recorded visual- (VGS) and memory-guided saccades (MGS) in 110 patients and 26 normal participants. Results: At the first visit, prior blocker users exhibited more severe vocal tics and OCD, but not motor tics, which persisted during follow-up. Patients treated with L-Dopa showed greater improvement of motor tics, but not vocal tics and OCD. Patients with and without blocker use showed similarly impaired MGS performance, while patients with blocker use showed more prominently impaired inhibitory control of saccades, associated with vocal tics and OCD. Discussion: Impaired MGS performance suggested a mild hypodopaminergic state causing reduced direct pathway activity in the (oculo-)motor loops of the basal ganglia–thalamocortical circuit. Blocker use may aggravate vocal tics and OCD due to disinhibition within the associative and limbic loops. The findings provide a rationale for discouraging blocker use and using low-dose L-Dopa in GTS.
Neurocognitive and adaptive phenotypes in adolescent inpatients with mood disorders: an exploratory study on disruptive mood dysregulation disorder in the framework of depressive disorders

Introduction Few studies on adolescents have investigated intelligence quotient (IQ) in mood disorders. Evidence on Disruptive Mood Dysregulation Disorder (DMDD), a controversial entity among depressive disorders, is more limited. Materials and methods We performed an exploratory study on adolescent inpatients with unipolar mood disorders to test specific impairment in cognitive and adaptive profile. We also considered common psychopathological comorbidities. We retrospectively collected data on inpatients with a diagnosis of major depressive disorder (MDD), DMDD or Depressive Disorder – Not Otherwise Specified (DD-NOS) evaluated with Wechsler Scales of Intelligence, Adaptive Behavior Assessment System (ABAS-II), and Children’s Global Assessment Scale (C-GAS). Results Out of 198 inpatients (85.9% females), 33.3% had MDD, 60.1% DD-NOS and 6.6% DMDD. DMDD patients had higher rates of ADHD (15.4%) and learning disorders (LD, 23.1%), a lower mean IQ (87.8 ± 10.7; p = 0.001) and ABAS-II scores (general composite 68.8 ± 16.8; p = 0.002) than other groups. In linear regression analysis, DMDD retained a significant correlation with lower IQ and adaptive abilities when controlling for sex, and comorbidities. Among comorbidities, LD correlated with lower perceptual reasoning and IQ, and ADHD with lower conceptual adaptive abilities. In all diagnosis groups, working memory and processing speed were lower than verbal comprehension and perceptual reasoning. Discussion While impairment in working memory and processing speed is a non-specific correlate of active mood disorder, DMDD is burdened by lower general intelligence and adaptive abilities and higher rate of neurodevelopmental comorbidities. Lower IQ in the normal range is a correlate of DMDD among variables examined, not explained by the effect of neurodevelopmental comorbidities. These findings are discussed with regards to possible implications for the consideration of DMDD as a bridge condition between neurodevelopmental disorders and mood disorders.
WEATHER INDEX WITH QUEUING COMPONENT FOR NATIONAL AIRSPACE SYSTEM PERFORMANCE ASSESSMENT

The impact of inclement weather – especially convective weather – on the National Airspace System (NAS) is a significant factor affecting NAS operational outcomes such as delays and user costs. It is important to develop objective measures of the combined impact of traffic demand and weather on the air traffic system. Previous efforts have led to the development of Weather Impacted Traffic Index (WITI) metric, a weighted sum of the en-route and terminal weather impact, which we have enhanced further by adding a queuing delay component. The three components are computed for OEP-35 airports on an hourly basis, allowing for a more in-depth analysis of operational impacts. This includes apportioning the impact of en-route convective weather to the affected airports (just as delays manifest themselves at airports). The new metric, the NAS Weather Index (NWX), has higher correlation with the ASPM Delay metric than earlier WITI versions. We have applied this methodology to the analysis of 2004-2006 NAS performance vis-a-vis operational impacts. The NWX metric can be produced on an hourly, daily or monthly basis, NASwide or regionalized. It is planned to be used for the FAA’s morning briefings, long-term post-season reviews, and future-NAS analyses. Future work includes developing methods for NAS outcome prediction based on weather forecast.
Linear Complexity for k-Coverage Sensor Redundancy Determination in IoT

Sensors play a crucial role in the IoT frameworks by enabling devices to collect and transmit data in k-coverage situations. However, maintaining k-coverage in a region of Interest (RoI) requires the concurrent activation of many sensors where at least $k$ nodes (k > 1), should cover each location in the sensing region. Due to overlaps in their sensing disks, sensors may be redundant and consume energy unnecessarily, in most k-coverage scenarios. In this paper, we propose SRA-Rot-klmax; a new redundancy algorithm that can affordably determine redundant sensors with a linear running time complexity even in k-coverage situations. A sensor is redundant in SRA- Rot-klmax, if its neighbors belong to particular sub-regions within its sensing disk denoted Flower areas (FA). A logical rotation with a certain angle value $a$ is preformed to determine all possible Flower areas of a sensing disk and their local coverage degree klmax. Finally, according to klmax of each sensor, the coverage degree of the entire RoI is obtained. Simulations show that the proposed algorithm outperforms well-known k-coverage protocols in terms of energy conservation, network lifetime, and coverage performance.
The nonlinear dynamics of the sea breeze

The Nonlinear Dynamics of the Sea Breeze. (August 2004) Kevin Robert Walter, B.S., Thomas More College Co-Chairs of Advisory Committee: Dr. John Nielsen-Gammon Dr. Craig C. Epifanio The response of the land and sea breeze circulation to two highly simplified dynamical models is presented. The first dynamical model is the explicit specification of an oscillating interior heat source analogous to that from Rotunno (1983). Emphasis is placed on the variation of the response with heating amplitude and latitude. In addition, a weakly nonlinear analysis focuses on the dynamic forcing of nonlinear features such as a semi-diurnal gravity wave, fronts, and asymmetry in the magnitude of onshore and offshore flow. One surprising result is the identification of a cycle-mean surface divergence pattern at both 0o and 45o. At 45o, this divergence pattern is accompanied by a cycle mean shore-parallel response due to the Earth’s rotation. The second dynamical model is the explicit specification of an oscillating surface heat flux. Again, comparison is made between simulations at different heating amplitudes, and between simulations at different latitudes. To address changes in the solution due to the heating method itself, comparison is made between solutions from the surface heating method and solutions from the interior heating method. Finally, solutions across the planetary continuum are explored for critical latitude dependence in high-amplitude simulations.
Phylogenetic and Structural Analyses of VPS13 Proteins in Archaeplastida Reveal Their Complex Evolutionary History in Viridiplantae

VPS13 is a lipid transfer protein family conserved among Eukaryotes and playing roles in fundamental processes involving vesicular transport and membrane expansion including autophagy and organelle biogenesis. VPS13 folds into a long hydrophobic tunnel, allowing lipid transport, decorated by distinct domains involved in protein localization and regulation. Whereas VPS13 organization and function have been extensively studied in yeast and mammals, information in organisms originating from primary endosymbiosis is scarce. In the higher plant Arabidopsis thaliana, four paralogs, AtVPS13S, X, M1, and M2, were identified, AtVPS13S playing a role in the regulation of root growth, cell patterning, and reproduction. In this work, we performed phylogenetic, as well as domain and structural modeling of VPS13 proteins in Archaeplastida in order to understand their general organization and evolutionary history. We confirmed the presence of human VPS13B orthologues in some phyla and described two new VPS13 families presenting a particular domain arrangement: VPS13R in Rhodophytes and VPS13Y in Chlorophytes and Streptophytes. By focusing on Viridiplantae, we were able to draw the evolutionary history of these proteins made by multiple gene gains and duplications as well as domain rearrangements. We showed that some Chlorophytes have only three (AtVPS13M, S, Y) whereas some Charophytes have up to six VPS13 paralogs (AtVPS13M1, M2, S, Y, X, B). We also highlighted specific structural features of VPS13M and X paralogs. This study reveals the complex evolution of VPS13 family and opens important perspectives for their functional characterization in photosynthetic organisms.
Relict rock glaciers, slope failure deposits, or polygenetic features? A re‐assessment of some donegal debris landforms

Large-scale debris landforms on the quartzite mountains of north-west Donegal were previously interpreted by the author as relict protalus rock glaciers and protalus ramparts. Re-assessment of these features and their adjacent terrain indicates that slope failures may have supplied much, if not all, of the debris. Implications arising from this recognition that other processes were involved in landform development are discussed and consideration is given to resolving the issue.