Miracle-dz/UniFAR-FTUs huggingface dataset:
Determination of Source of Hyperandrogenism and Comparisons of Hormonal and Metabolic Profile in Different Phenotype of PCOS: A Hospital Based Study

Objective: Metabolic parameters in polycystic ovary syndrome (PCOS) correlate to their phenotypic presentations and sources of hyperandrogenism. Till date no studies have evaluated the source of hyperandrogenism among phenotypic variants of PCOS. Therefore we determined the sources of hyperandrogenism and compared the metabolic parameters in different phenotypes of PCOS. Material method: Study included 120 PCOS patients and 15 age matched controls. PCOS were diagnosed by revised Rotterdam criteria (2003). Different phenotypic presentations like polycystic ovary (P), ovulatory dysfunction (O) and hyperandrogenism (H) were evaluated and compared for anthropometrical, hormonal and metabolic parameters. They were correlated with the source of androgen excess following post Leuprolide acetate (20 μg/kg) 17-OHP and post synacthen (250 μg) DHEAS measurement. Result: This study had 2 phenotypic presentations i.e. PHO (80%) and OH (20%) out of 4 phenotypic presentations described by Rotterdam among all PCOS (may be due to referral bias). Among obese PCOS 87.5% had PHO and 12.5% had OH phenotypes, while it was 75% and 25% in normal weight PCOS. PHO phenotypes had adrenal and ovarian source of hyperandrogenism. Fasting insulin and HOMA-IR were higher in non-obese PHO than obese PHO but statistically insignificant. Serum DHEAS (delta steroid) had a negative but serum testosterone (keto steroid) had positive correlation with IR in PCOS. Conclusion: Both adrenal and ovarian hyperandrogenism was found in PHO as compared to OH phenotype that had only ovarian hyperandrogenism. Normal weight PCOS had less chance of getting ultrasound abnormalities compared to obese PCOS. PHO phenotypes, who had a greater degree of serum DHEAS had a better metabolic profile despite a greater BMI. So our result suggests that distinction between source of hyperandrogenism and evaluation of different phenotype is beneficial in predicting metabolic risk and future management.
A prospective questionnaire based study to assess the knowledge and attitude about pharmacovigilance among undergraduate medical students in a tertiary care teaching hospital

Study background: inculcating knowledge and attitude in health professionals especially young budding doctors and other health professionals is the best way to overrule the under reporting in pharmacovigilance. Objective: To assess the knowledge and attitude about pharmacovigilance in medical students in a tertiary care hospital in Tamil Nadu. Materials and methods: It is a prospective questionnaire based study. The questionnaire containing 17 questions to evaluate knowledge and attitude among MBBS students. Results: The data were entered in MS excel sheets and analyzed using appropriate statistical method. This study shows mean score of 59.6% and 57.5% in knowledge and attitude domain of the questionnaire. Conclusion: There is improvement in knowledge and attitude in our study when compared to studies conducted in previous years by others. The inclusion of pharmacovigilance chapter in the medical undergraduate curriculum has improved knowledge and attitude among medical undergraduates. Further recent addition of syllabus to develop skills in undergraduates to interpret ADR and handling Spontaneous reporting forms in the practicals will significantly improve ADR reporting in future years.
Doctor-Patient Communication, What is the Situation? An Intervention Study at a Selected Governmental Hospital in Sharkia Governorate

Background: Good doctor-patient communication has multiple impacts as higher compliance, satisfaction for both patients and clinicians and decrease in malpractice. Objective(s): To assess physicians’ perception towards importance of effective doctor-patient communication, as well as to measure their actual practice and skills of communication according to the items of the Kalamazoo checklist before and after training program. Methods: An intervention study was carried out at outpatient clinics in a general hospital at Zagazig district. A randomly selected sample of 198 physicians was chosen. The phases of the study were: 1- Assessing the level of doctor patient communication practice using the Kalamazoo Checklist. 2- Assessing physicians’ perception towards effective communication, using a self-administered questionnaire. 3- Assessing the level of doctor patient communication practice after training program. Results: 46.5% of physicians highly perceived the importance of effective communication; with higher perception among females. The highest perceived items (more than 80%) were the effect of good communication on patients’ compliance, patients’ satisfaction and physicians’ satisfaction. The intervention program significantly improved the physicians’ communication skills. Conclusion: Less than half of the physicians highly perceived the importance of effective communication. Training can significantly impact communication skills. Keywords : doctor-patient communication
Influence of Overconfidence and Cash Flow on Investment in Vietnam

CEOs Overconfidence can bring potentially risky early decisions to businesses, along with large enterprise free cash flow that can bring different investment decisions with CEOs Overconfidence. Especially in the context of Vietnamese enterprises, CEOs are often influenced by behavioral psychology about overconfidence in investment decisions (due to individual cultural characteristics as well as operating financial markets also depend on many factors outside the market). Therefore, the authors study the impact of overconfidence and cash flow on investment in Vietnamese to find the internal relationship between these three factors in the financial environment in Vietnam. With 480 companies listed on the Vietnam Stock Exchange from 2014 to 2018 (companies have continuous reports), the regression analysis results with panel data (FEM, GLS models, correction of robust and GMM dealing with endogenous problems) have shown Overconfidence has a positive impact on investment. At the same time, the results also indicated that enterprises with overconfident CEOs and large cash flows tend to invest less than enterprises with low cash flow. The results of this study have shown the behavioral behavior of CEOs in Vietnamese enterprises that exist under both prospect theory and effective market theory.
Exploring the relationship between metabolic syndrome and sleep amongst adults in the UK

The metabolic syndrome (MetS) is routinely operationalised as a cluster of adverse risk factors for both cardiovascular heart disease and type 2 diabetes. Amongst the risk factors which may contribute to the development (and consequences) of MetS is sleep. The overarching aim of the present thesis is to generate an improved understanding of the available evidence regarding the speculative relationship between sleep and MetS. After a systematic review and meta-analysis of previous empirical studies exploring the relationship between MetS and sleep, the present study draws on a large-scale, nationally representative survey of UK adults in which directly measured and self-reported MetS symptoms/components and self-reported sleep characteristics have been recorded; and assesses the reliability of self-reported indicators of MetS before re-evaluating the association between MetS and sleep. The systematic review suggested that, while there is some evidence of an association between MetS and sleep across a range of sleep-related characteristics, this evidence draws on a small number of non-UK cross-sectional studies, some of which involved methods that are prone to error and bias. On the other hand, the self-reported MetS components identified in the UKHLS questionnaires provided substantial agreement with direct measures thereof. The subsequent associations observed between three key components of MetS (elevated waist circumference; high blood pressure; and diabetes – and different combinations thereof) and seven self-reported sleep characteristics were dependent upon: the specific sleep characteristic examined; the choice of referent group used; adjustment for sociodemographic and/or lifestyle covariates; and the use of self-reported or directly measured MetS components. Key differences between these findings and those of previous studies suggest these associations remain speculative and subject to methodological and contextual variation between studies.
Does the CSR Message Matter? Untangling the Relationship Between Corporate–Nonprofit Partnerships, Created Fit Messages, and Activist Evaluations

This study unpacks the complex relationship between corporate–nonprofit partnerships, corporate social responsibility (CSR) communication, and stakeholder evaluations of fit. We move beyond the fundamental question of whether partner fit matters to questions about what types of messages matter, under what conditions, and to whom. We conducted an online experiment (N = 966) to test created fit messages’ ability to influence stakeholder perceptions of corporate–nonprofit partnership fit. Grounded in the symbiotic sustainability model, we find that created fit messaging results in stakeholders having more favorable evaluations of corporate–nonprofit partnership fit. However, we also identify differences in the effectiveness of created fit messaging across potential partnerships. In addition, we find, beyond message type and level of partner congruity, the degree of CSR activism influences stakeholders’ responses to created fit messaging in counterintuitive ways.
Peran Self Efficacy dan Iklim Organisasi dalam membentuk Employee Engagement melalui Komitmen Organisasi

This study aims to determine the effect of self-efficacy and organizational climate on employee engagement with organizational commitment as a mediator. The subjects who participated in this study were 110 employees of a travel agent company. Data was collected using scales namely Self-Efficacy, Organizational Climate, Organizational Commitment, and Employee Engagement scales and analyzed using SEM analysis techniques. The results showed a significant effect of self-efficacy and organizational climate on employee engagement with organizational commitment as a mediator variable with a correlation coefficient r = 0.575 and r = 0,478 (significance level (p) = 0.001). These results indicate that organizational commitment can mediate self-efficacy towards Employee engagement by providing an effective contribution of 33.1% and mediating organizational climate of employee engagement with an effective contribution of 22.8.
Behaviour of free-range laying hens in distinct outdoor environments

The outdoor range in free-range, egg-production systems contains features that aim to promote the performance of natural behaviours. It is unclear what features of the range laying hens prefer and how these influence hen behaviour. We hypothesised that hens would demonstrate a preference for features of the environment in which their ancestor evolved, such as relatively dense vegetation, within the outdoor range and that the behavioural time budget of hens will differ between distinct environments. Characteristics of the outdoor range in one free-range commercial egg farm were mapped and four distinct environments (‘locations’) were identified based on ground substrate and cover (Wattle Tree, Gum Tree, Bare Earth and Sapling). The number of hens accessing each location and behavioural time budget of these hens was recorded over a three-week period during the southern hemisphere summer (January–February). Hens showed a clear preference for the Wattle Tree and Gum Tree locations; however, a significant interaction between location and time of day suggested that the hens’ preference for different locations changed throughout the day. The most common behaviours displayed by hens were foraging, preening, locomotion, resting and vigilance, and most behaviours were influenced by the interaction between location and time of day. Overall, a wider variety of behaviours were performed in the highly preferred environments, but not all behaviours were performed equally within each environment throughout the day. Understanding what features hens prefer in the outdoor range and how this influences the performance of natural behaviours is important in promoting the welfare of hens in free-range production.
Hemodynamic modeling of aspirin effects on BOLD responses at 7T

Aspirin is considered a potential confound for functional magnetic resonance imaging (fMRI) studies. This is because aspirin affects the synthesis of prostaglandin, a vasoactive mediator centrally involved in neurovascular coupling, a process that underlies the blood oxygenated level dependent (BOLD) response. Aspirin-induced changes in BOLD signal are a potential confound for fMRI studies of patients (e.g. with cardiovascular conditions or stroke) who receive low-dose aspirin prophylactically and are compared to healthy controls that do not take aspirin. To examine the severity of this potential confound, we combined high field (7 Tesla) MRI during a simple hand movement task with a biophysically informed hemodynamic model. Comparing elderly volunteers with vs. without aspirin medication, we tested for putative effects of low-dose chronic aspirin on the BOLD response. Specifically, we fitted hemodynamic models to BOLD signal time courses from 14 regions of the human motor system and examined whether model parameter estimates were significantly altered by aspirin. While our analyses indicate that hemodynamics differed across regions, consistent with the known regional variability of the BOLD response, we neither found a significant main effect of aspirin (i.e., an average effect across brain regions) nor an expected drug×region interaction. While our sample size is not sufficiently large to rule out small-to-medium global effects of aspirin, we had adequate statistical power for detecting the expected interaction. Altogether, our analysis suggests that low-dose aspirin, as used for prophylactic purposes, does not strongly affect BOLD signals and may not represent a critical confound for fMRI studies.
Sero-epidemiological Study of Herpes simplex virus type 1 infections in outpatient population referred to clinical laboratories in Gorgan, IRAN 2006

هدیکچ فده و هنیمز : پیت سکلپمیس سپره یسوریو تنوفع 1 ار دوخ ینیلاب تارهاظت ثکا ر ًا هب هداد ناشن لاخ بت تروص تسا اجیا هب رداق یلو ،یلسانت سپره ،هینرق باهتلا دننام ییاهیرامیب د دشاب یم زین یدازون سپره و تیلافسنا . قیقحت نیا رد تنوفع کیژولویمدیپاورس نییعت هب سپره پیت سکلپمیس 1 رد ناگرگ رهش یاههاگشیامزآ هب ناگدننک هعجارم دوب رظن دم . یسررب شور : اگشیامزآ هب ناگدننک هعجارم هعلاطم دروم هعماج یصوصخ و یتلود یاه ه دوب ناگرگ رهش . زا دارفا ینس عیزوت 1 ات 83 دش یم لماش ار لاس . دادعت زا 406 هب هدننک هعجارم رفن 10 دش هتفرگ نوخ هنومن یفداصت روط هب رهش حطس هاگشیامزآ . هاگشیامزآ نامه رد دارفا نیا نوخ مرس اگشیامزآ هب نابلطواد هدش رپ همانشسرپ اب هارمه و ادج هتفای لاقتنا یکشزپاریپ هدکشناد ینیلاب تاقیقحت ه و دض یداب یتنآ دوجو رظن زا ازیلاا شور اب HSV-1 دندیدرگ شیامزآ . اه هتفای : هک داد ناشن یسررب نیا 49 % دض یداب یتنآ یاراد دارفا HSV-1 ) یارب IgG و
Detecting guilt-presumption in a police-suspect interview: An evaluation of the questions in a murder case

Controlled studies have demonstrated that guilt-presumptive questions usually accompany interviewer guilt bias and accusatory behaviours towards a suspect. When evaluating police-suspect interviews, however, conventional methods primarily focus on the appropriateness of questions, and guilt-presumption is not featured as a questioning strategy. Instead, guilt-presumptive utterances are aggregated with other types of inappropriate opinion statements. There is often more happening within an interview than is immediately identifiable by simply focusing on question types. Examining the interactivity and behaviours that lead to accusations can reveal subtleties that have a profound influence on the flow and outcome of the interview. To demonstrate this, we analysed six interviews from a single Dutch murder investigation for guilt-presumptive language (accusations and insinuations of guilt) and question appropriateness. We then analysed the police-suspect interactions within the interview that occurred prior to, and immediately after the guilt-presumptive language was used. The findings demonstrated that accusations prompted suspect denials, facilitated a drastic decline in suspect cooperation, and impeded the ability for interviewers to gain investigation relevant information (IRI). We argue that more applied research on guilt-presumptive language is needed in the investigative interviewing literature, particularly in the context of biased decision-making regarding questioning strategies.
Study of Clinical and Biochemical Profile in Neonatal Seizure in a tertiary care centre of Jharkhand

Background: Neonatal seizures are one of the most common and distinctive clinical manifestations of dysfunction of neurological system. Neonatal seizures represent responses of the immature nervous system to varied insults resulting in considerable neonatal mortality and morbidity including motor and cognitive disabilities in the childhood. Neonatal seizures are more common in preterm compared to term neonates and metabolic abnormalities are common cause of neonatal seizure. Objectives: Current study aims at to study: 1. the incidence of biochemical abnormalities associated with neonatal seizure & 2. The clinical presentation, time of onset and its relation to the neonatal seizures. Methods: A prospective hospital based study was conducted for a period of 6 months from May 2017 to November 2017, a total of 80 newborns with seizure were enrolled in the study after taking complete history and appropriate physical examination. Blood sample was collected for detecting metabolic abnormalities before instituting specific therapy. Results: In my study, neonatal seizure occurred more commonly in term babies especially in appropriate for gestational age babies compared to preterm neonates. There was a male predominance. Most seizures are due to intramural deliveries and occurred within 72 hours of life. Seizures are more common in babies with birth weight ≥2.5 kg and subtle seizure is the most common type. The most common biochemical abnormality noted was hypoglycemia (40%) and hypocalcemia (32%). There were cases reported with combination of hypoglycemia / hypocalcemia and hypocalcemia/hypomagnesemia particularly in preterm but their incidence is low. Conclusion: The transient metabolic abnormalities are easily treatable when identified early and are associated with good prognosis. Hence biochemical work up should be done in all neonates with seizure and should be included as the first line of investigation in all cases, thereby preventing the further occurrence of seizure and overuse of anticonvulsants. It also improve the prognosis and outcome of the neonate and prevent the long term neurological sequelae associated with it.
A Comprehensive Exploration of the lncRNA CCAT2: A Pan-Cancer Analysis Based on 33 Cancer Types and 13285 Cases

Whether the lncRNA CCAT2 expression level affects the clinical progression and outcome of cancer patients has not yet been fully elucidated. There is still an inconsistent view regarding the correlation between CCAT2 expression and clinicopathological factors, including survival data. Besides, the regulation mechanism of CCAT2 in human cancer is still unclear. Our study analyzed a large number of publication data and TCGA databases to identify the association of CCAT2 expression with clinicopathological factors and to explore the regulatory mechanisms in human cancers. We designed a comprehensive study to determine the expression of CCAT2 in human cancer by designing a meta-analysis of 20 selected studies and the TCGA database, using StataSE 12.0 to explore the relationship between CCAT2 expression and both the prognosis and clinicopathological features of 33 cancer types and 13285 tumor patients. Moreover, we performed GO and KEGG pathway enrichment analyses on potential target genes of CCAT2 collected from GEPIA and LncRNA2Target V2.0. The level of CCAT2 expression in tumor tissues is higher than that in paired normal tissues and is significantly associated with a poor prognosis in cancer patients. Besides, overexpression of CCAT2 was significantly associated with tumor size, clinical stage, and TNM classification. Meanwhile, CCAT2 expression is the highest in stage II of human cancer, followed by stage III. Finally, 111 validated target gene symbols were identified, and GO and KEGG demonstrated that the CCAT2 validation target was significantly enriched in several pathways, including microRNAs in the cancer pathway. In summary, CCAT2 can be a potential biomarker associated with the progression and prognosis of human cancer.
Oil and stock market interlinkages: The case of the GCC bloc

Accounting and Finance Division Doctor of Philosophy Oil and stock market interlinkages: The case of the GCC bloc by Salem Ziadat Motivated by increased stock market integration, gaps in the literature and the recent financialization of oil markets, this thesis studies the behaviour of the fledgling Gulf Cooperation Council (GCC) stock markets against innovations in international financial markets and oil prices. The key results of the thesis highlight the relative segregation of the GCC markets and the importance of the EU and the UAE in determining the interand intraregional equity linkages, respectively. In terms of their reactions to oil shocks, similar to the financial markets of oil-exporting nations, the GCC markets are stimulated by oil precautionary demand shocks during bearish phases, yet, the intensity of the impact is significantly more pronounced. Also, oil price change is a key factor of the US-GCC and EUGCC stock market interdependence. Finally, oil innovations display upper tail dependence with US-GCC and EU-GCC correlations. The dissertation contributes to the existing literature by remapping the information transmission mechanism in the GCC by examining the interand intra-regional linkages in the GCC while considering both mean and variance linkages. Additionally, using the Kilian (2009) method, the thesis contributes to the literature by examining oil shocks influence on the GCC markets in contrast to their counterparts in oilexporting and importing economies. Notably, this research characterises the oil-equity relation depending on the type of oil shock, the energy profile of the country and the state of the financial market. Finally, for the first time in the macroeconomic literature, the thesis establishes oil as a key macroeconomic determinant in the GCC stock market interdependence. The results present the GCC as a fresh destination to welcome funds from global investors and portfolio managers interested in cross-country diversification benefits. Also, oil price change is presented as a tool to forecast equity correlations which is vital for portfolio construction and balancing efforts. The outcome of the thesis conveys information for domestic policymakers in the GCC attempting to formulate macroeconomic policies. Finally, the outcomes contribute to academic efforts in understanding the interrelations between financial markets in the context of emerging/frontier markets.
Individualized Therapy for Persistent Asthma in Young Children

AM Fitzpatrick, DJ Jackson, DT Mauger. J Allergy Clin Immunol. 2016;138(6):1608–1618.e12 To determine if a differential response to asthma controller medications exists among young children with a history of wheezing requiring step 2 therapy and if this response can be predicted by phenotype and clinically available biomarkers. Enrolled subjects were 300 children aged 12 to 59 months who required step 2 asthma therapy, including those who were naive to inhaled corticosteroids (ICSs) and leukotriene receptor antagonist (LTRA) medications and those who had been treated with low-dose ICSs or LTRAs at any point in the 6 months before enrollment but still experiencing symptoms warranting daily controller medication. This …