Miracle-dz/UniFAR-FTUs huggingface dataset:
VHRM_A_198452 221..227

Zohair A Al Aseri Syed Shahid Habib Ameer Marzouk 1Department of Emergency Medicine, King Saud University & Medical City, Riyadh, Saudi Arabia; 2Department of Physiology, King Saud University & Medical City, Riyadh, Saudi Arabia; 3College of Medicine Research Center, King Saud University & Medical City, Riyadh, Saudi Arabia Background: High sensitivity C-reactive protein (hsCRP) predicts myocardial dysfunction after acute coronary syndromes. We aimed to study the association of hsCRP estimation at first acute myocardial infarction (AMI) with myocardial dysfunction and heart failure. Methods: This research was carried out at the Department of Physiology and Department of Emergency Medicine, King Khalid University Hospital, King Saud University, Riyadh, Saudi Arabia. In this prospective study, 227 patients were studied. hsCRP levels were estimated when patients came to the emergency department at AMI, 7 days post AMI, and at 12 weeks of follow up after AMI. The outcome was change in myocardial functions, especially heart failure, 12 months after the attack. Results: Based on a cutoff mean value of hsCRP levels at admission (10.05±12.68 mg/L), patients were grouped into high and low C-reactive protein (CRP.) The ejection fraction was significantly lower at follow up in the high CRP group (37.29±12.97) compared to the low CRP group (43.85±11.77, p<0.0198). hsCRP had significant inverse correlation with left ventricular ejection fraction (r=−0.283, p<0.01). About 38.1% patients showed heart failure, with 23.6% in the high CRP group and 14.5% in the low CRP group (OR 2.4, p=0.028). Receiver operating characteristic curve analysis showed that CRP levels at AMI had a specificity of 79% and sensitivity of 83% to predict heart failure. Conclusion: A high hsCRP level measured at first AMI predicts myocardial dysfunction and heart failure. It is suggested that hsCRP plays an important role in the development of heart failure after myocardial infarction.
Open to competition? Competitive density and the growth of young New Zealand ventures

Drawing on 180 survey responses from young, New Zealand-based ventures, we investigate effects of the number of perceived serious competitors on venture growth. We find empirical evidence for an inverse U-shaped relationship between competitive density and young venture growth. We further find that persistent innovation – requiring both initial innovative intent and a recent record of innovation – not only promotes young growth but also moderates the relationship between competitive density and young venture growth. Overall, the study shows that the growth of young ventures committed to persistent innovation is less affected by competitive dynamics compared to non-innovators. JEL Classification: L10, L22, L26, O30
CLEP_A_225568 1015..1024

1Fundació Institut Universitari per a la Recerca a l’Atenció Primària de Salut Jordi Gol i Gurina (IDIAPJGoL), Barcelona, Spain; 2Universitat Autònoma de Barcelona, Bellaterra (Cerdanyola del Vallès), Cerdanyola del Vallès, Spain; 3Unitat d’Epidemiologia i Registre de Càncer de Girona (UERCG), Pla Director d’Oncologia, Institut Català d’Oncologia, Institut d’Investigació Biomèdica de Girona (IdIBGi), Universitat De Girona, Girona, Spain; 4CIBER de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; 5Catalan Cancer Plan, Department of Health of Catalonia, Barcelona, Spain; 6Department of Clinical Sciences, University of Barcelona (UB), Barcelona, Spain; 7Registre de Càncer de Tarragona, Fundació per a la Investigació i Prevenció del Càncer (FUNCA), IISPV, Reus, Spain; 8Cancer Prevention Unit and Cancer Registry, Department of Epidemiology and Evaluation, Hospital del Mar, Barcelona, Spain
ROLE OF THYROID DYSFUNCTION IN INFERTILE WOMEN WITH MENSTRUAL DISTURBANCES

Background: Normal thyroid function is necessary to maintain reproductive physiology. An abnormality in its function may be the cause of infertility manifesting as abnormal menstrual cycle. The objective of this study was to find the role of thyroid dysfunction in primary and secondary infertile women with menstrual disturbances. Material & Methods: A total of 168 subjects comprising of 106 primary and 62 secondary infertile women were evaluated. Their detailed clinical and menstrual histories were obtained and their blood samples were taken for thyroid profile. Results: Out of 168 infertile patients 134(79.76%) had euthyroid, 31(18.45%) hyperthyroid and only 3(1.78%) patients had hypothyroid profile. Irregular menstrual cycles were found in 10 out of 31 (32.25%) hyperthyroid, 2 out of 3 (66.66%) hypothyroid and 21 out of 134 (15.67%) euthyroid infertile women. A significant p-value was obtained on comparison of thyroid profile with irregularities in menstrual cycle. Conclusion: It was found that an abnormal thyroid profile may be the cause of infertility in women presenting with menstrual disturbances.
“Tax me, but don’t drown me in regulations: Understanding differences in corruption across the countries of Europe"

Differences in corruption perception across the countries of Europe are marked and persistent over time. This study seeks to explain these differences in the countries of both the European Union and the European Free Trade Association during 2007–2017. The core hypothesis is that the style of government intervention in the economy –rather than the size of government– is the main explanatory factor for the differences. To test this hypothesis, the empirical analysis disentangles the effects of the two main government tools for intervention in the economy: taxation and regulation. The main result is that the fiscal burden does not consistently present a significant relationship with corruption. In contrast, the regulatory burden associated with excessive red tape is a strong driver of corruption, because a consistent and significant positive association is found. Furthermore, differences in legal origins, history, democratic experience and several economic factors contribute to explaining differences between European countries
An Alternative Science Kit for Finding the Liquid Density Based on Archimedes’ Principle

A simple experimental setup for finding the liquid density with known mass and volume of floating objects using Archimedes’ was developed as a teaching tool for Archimedes’ Principle. The instrumentation consists of a set of 5 similar-volume cylindrical bottles filled with sand with different masses whose overall densities are less than the liquid whose density needed to be identified. By floating that series of objects in an unknown liquid, the height of object above liquid was recorded. When plot the height of object above liquid (y-axis) versus the mass of floating object (x-axis), the absolute liquid density and the volume of a set of objects could be calculated from the slope and the intercept on y-axis, respectively. Pre-test and post-test were performed before and after using the teaching tool for a small group of 9 high school students in the preparation course before becoming undergraduate students. The improvement of post-test score indicated the understanding of buoyancy of the students. This simple teaching kit can be adapted for the teaching of buoyancy and linear equation for students in the secondary school.
Anterior Sensory Myelopathy: A Retrospective Observational Case Series of an Overlooked Neurological Disorder

Background: Individuals with cervical myelopathy can sometimes present with more subtle signs and symptoms of loss of pain and temperature sensation from compression of the anterolateral spinothalamic tract without involvement of other spinal cord tracts. It is necessary to recognize early and subtle forms of myelopathy. Objective: The purpose of this report is to describe a series of patients who present with a mostly sensory cervical myelopathy from a radiographically documented spinal cord compression of the anterolateral spinothalamic tract. Methods: This study is a retrospective case series. Individuals were selected who presented with radiographic documentation of cervical spinal cord compression and loss of pain and/or temperature sensation below the level of the compression. Individuals who exhibited signs of corticospinal tract dysfunction (weakness, hyperreflexia, ataxia and/or pathological spinal reflexes) were excluded. Results: Seven individuals (age range 36 to 52, mean 42.4) were identified as having loss of sensation to pain and/or temperature below and contralateral to the level of anterior spinal cord compression. In all cases, the compression was due to a cervical herniated intervertebral disc. No patient had lower extremity weakness, hyperreflexia, or spasticity. No patient had spinal sensory evoked potential abnormality. Conclusion: Cervical disc compression of the anterior spinal cord can lead to dysfunction of pain and temperature sensation without causing typical signs of myelopathy. Most patients who present with this myelopathy syndrome also present with pain and are likely treated with conservative medical therapy. This series highlights a very subtle form of myelopathy that is not widely recognized.
Exit Channels of Venture Capital : Cross-Border Venture Capital Investments and Globalization of Enterprises

Tampereen ammattikorkeakoulu Tampere University of Applied Sciences Degree Programme in International Business NAO NAKATANI: Exit Channels of Venture Capital Cross-Border Venture Capital Investments and Globalization of Enterprises Bachelor's thesis 50 pages October 2019 The thesis was written to study the impact of the involvement of venture capitalists on young companies: especially on internationalization of young businesses, when the investments were done by venture capitalists with foreign backgrounds. This was done with primary aim of encouraging entrepreneurs to strategically select investors for their nascent business by analyzing what ‘value-added’ venture capitalists would possibly bring, other than the money they invest. Moreover, the thesis gave particular focus on the changes in exit channel of domestic investments and of cross-border investments. The outcome was essentially addressed to venture market in Finland, since the research was conducted with Finnish venture capitalists. The theoretical framework included the symbolic value-adding activities of venture capital, geographic distance investments and the risk management methods of venture capital: specialization and diversification and such. The basics of venture financing and venture capital were also described in the paper. The research took qualitative approach; interviews with Finnish venture capitalists were carried out. Data of annual flow of Finnish venture capital was provided by FVCA (Finnish Venture Capital Association). The result of the research suggested no direct linkage between the presence of foreign venture capitalists in investments and the foreign exit of the portfolio companies. However, it supported the theory of accelerated market expansion of portfolio companies in foreign countries when it was backed by foreign venture capitalists because of the wider reach and advanced knowledge in those markets that foreign venture capitalists could provide. Additionally, the thesis raised a proposal of less defined concept or, weakening definition of cross-border investment especially in Europe.
PUBLISHED VERSION

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Dynamic Systems and Applications 19 (2010) 611-624 DELAY-DEPENDENT H∞ CONTROL FOR MARKOVIAN JUMP SYSTEMS WITH DELAYS VARYING IN A RANGE

ABSTRACT. This paper presents a new method for H∞ state feedback controller design of Markovian jump systems with delays varying in a range. Firstly, results on delay-dependent stability and H∞ performance are established by exploiting a new Lyapunov functional making full use of information about time delay and Jensen’s inequality. Neither free weighting variables nor model transformation is used in the derivation of less conservative criteria. Secondly, based on the obtained conditions, a new design of state feedback controller is developed in terms of linear matrix inequalities (LMIs). Finally, illustrative examples are presented to show the advantage and validity of the proposed approaches.
Two Dimentional of Self-Esteem: Testing of Mruk’s Model

The aim of this study is to test Mruk (2006b) 's model by examining the relationship between high and low self esteem with the authentic self, narcissism, antisocial behavior and depression in the light of the two-dimensional self-esteem model. A total of 266 students, 182 female and 84 male, participated in different departments of a Faculty of Education. The ages of the students ranged from 18 to 31 (mean: 21.15, sd: 2.13). Data were obtained by Two-Dimensional Self-Esteem Scale, Authentic Self Scale, Narcissistic Personality Scale, Anti-Social Tendency Scale, Depression, Anxiety and Stress Scales. According to scores the self-esteem scale, participations were divided into four groups. In the study, the hypotheses determined by Mrunk’s model. The hypotheses of the study were tested by ANOVA and regression analysis. Results showed subjects with high SE were obtained higher score than others in their authentic self. And subjects of low SE were the highest depression scores. The findings are discussed in the context of Mruk's model, two-dimensional self-esteem, authentic self, antisocial behaviors and depression variables.
Craig-Gordon model validation using observed meteorological parameters and measured stable isotope ratios in water vapor over the Southern Ocean

Abstract. The stable isotopic composition of water vapor over the ocean is governed by the isotopic composition of surface water, ambient vapor isotopic composition, exchange and mixing processes at the water-air interface as well as the local meteorological conditions. In this study we present water vapor and surface water isotope ratios in samples collected across the latitudinal transect from Mauritius to Prydz Bay in the Antarctic coast. The samples were collected on-board the ocean research vessel SA Agulhas during the 9th (Jan-2017) and 10th (Dec-2017 to Jan-2018) Southern Ocean expeditions. The inter annual variability of the meteorological factors governing water vapor isotopic composition is explained. The parameters governing the isotopic composition of evaporation flux from the oceans can be considered separately or simultaneously in the Craig-Gordon (CG) models. The Traditional Craig-Gordon (TCG) (Craig and Gordon, 1965) and the Unified Craig-Gordon (UCG) (Gonfiantini et al., 2018) models were used to evaluate the isotopic composition of evaporation flux for the molecular diffusivity ratios suggested by Merlivat (1978) (MJ), Cappa et al. (2003) (CD) and Pfahl and Wernli (2009) (PW) and for different ocean surface conditions. We found that the UCG model with CD molecular diffusivity ratios where equal contribution from molecular and turbulent diffusion is the best match for our observations. By assigning the representative end member isotopic compositions and solving the two-component mixing model, a relative contribution from locally generated and advected moisture was calculated along the transect. Our results suggest varying contribution of advected westerly component with an increasing trend upto 65° S. Beyond 65° S, the proportion of Antarctic moisture was found to be increasing linearly towards the coast.
DDDT_A_219074 3607..3623

Chan Zhang Ronggan Liang Xiaowen Gan Xiufang Yang LingLin Chen Jie Jian 2 1Department of Pharmacology, Xiangya Hospital, Central South University, Changsha, Hunan, People’s Republic of China; 2Department of Pharmacology, Guilin Medical University, Guilin, Guangxi, People’s Republic of China Background/Aims: Epigallocatechin gallate (EGCG) has established protective actions against myocardial ischemia/reperfusion (I/R) injury by regulating autophagy. However, little is known about themechanisms of EGCG in posttranscriptional regulation in the process of cardioprotection. Here we studied whether microRNAs play a role in EGCG-induced cardioprotection. Methods: The myocardial I/R injury in vitro and in vivo model were made, with or without EGCG pretreatment. The upregulation and silencing of microRNA-384-5p (miR-384) and Beclin-1 in H9c2 cell lines were established. Rats were transfected with miR-384 specific shRNA. Dual-luciferase reporter gene assay was conducted to verify the relationship between miR-384 and Beclin-1. TTC staining was performed to analyze the area of myocardial infarct size. Cell viabilitywasmonitored by cell counting kit-8 (CCK-8). The release of cardiac troponinI (cTnI) was examined by ELISA. The levels of autophagy-related genes or proteins expression were evaluated by qRT-PCR or Western blotting. Autophagosomes of myocardial cells were detected by transmission electron microscopy and laser scanning confocal microscope. Results: I/R increased both autophagosomes and autolysosomes, thereby increasing autophagic flux both in vitro and in vivo. Pretreatment with EGCG attenuated I/R-induced autophagic flux expression, accompanied by an increase in cell viability and a decrease in the size of myocardial infarction. MiR-384 expression was down-regulated in H9c2 cell lines when subjected to I/R, while this suppression could be reversed by EGCG pretreatment. The dual-luciferase assay verified that Beclin-1 was a target of miR-384. Both overexpression of miR-384 and knocking down of Beclin-1 significantly inhibited I/R-induced autophagy, accompanied by the activation of PI3K/Akt pathway, thus enhanced the protective effect of EGCG. However, these functions were abrogated by the PI3K inhibitor, LY294002. Conclusion: We confirmed that EGCG has a protective role in microRNA-384-mediated autophagy by targeting Beclin-1 via activating the PI3K/Akt signaling pathway. Our results unveiled a novel role of EGCG in myocardial protection, involving posttranscriptional regulation with miRNA-384.
Design of stroke imaging package study of intracranial atherosclerosis: a multicenter, prospective, cohort study.

Background Intracranial atherosclerosis (ICAS) is a major cause of stroke worldwide. However, much remains unknown regarding its underlying pathophysiology. High-resolution magnetic resonance imaging (HR-MRI) can clearly display intracranial vessel wall lesions in vivo. The aim of stroke imaging package study of ICAS (SIPS-ICAS) study is to explore the stroke mechanisms of symptomatic ICAS, the dynamic changes under aggressive medical treatment and their associations with clinical events using conventional MRI sequences plus HR-MRI. Methods This is a multicenter, prospective, cohort study recruiting first-ever acute ischemic stroke patients attributed to intracranial large artery stenosis (>50% or occlusion). Subjects undergo a pre-designed stroke imaging packages at baseline and are recommended to receive aggressive medical treatments. Participants will be followed up for functional outcome, stroke recurrence, and death events at 3, 6 and 12 months and retake HR-MRI imaging at 6 months. Results Enrollment began in November 2018 and 96 patients have been enrolled as of September 2019. Conclusions The SIPS-ICAS study will provide insights into the pathophysiology of ICAS and identify specific imaging markers for risk stratification and prognosis prediction. At the same time, the feasibility and validity of the new stroke imaging package including HR-MRI will be assessed, which is promising for clinical routine use.
Multiple electrode aggregometry – only for cardiologists?

Multiple electrode aggregometry is one of the newest technologies in platelet function monitoring. The idea of this assay is based on whole blood impedance aggregometry measurements. The main advantages of this device are rapid and easy use, no necessity of sample pre-processing or requiring a specialized laboratory. These features allow one to include this methodology in point-of-care testing methods that can be performed at the patient bedside. Five different pathways of platelet activation can be investigated by adding specific reaction agonists. Antiplatelet drugs, such as acetylsalicylic acid or clopidogrel, inhibit arachidonic acid-dependent and adenosine diphosphate-dependent pathways of platelet activation. Individual patient response to these drugs can be estimated using multiple electrode aggregometry. The identification of low-responders may result in reducing thrombosis events in this group and make antiplatelet treatment more effective. Furthermore, it is supposed to be a reliable method of estimating the risk of perioperative bleeding in adults undergoing cardiac surgery. Other potential clinical applications for this technology are being found. Many studies report its use in determining prognosis in severe sepsis, detecting heparin-induced thrombocytopenia and diagnosing von Willebrand disease. Although multiple electrode aggregometry seems to have great diagnostic potential, more tests need to be performed before it becomes standard hospital equipment.
Studies of the edge pedestal and behaviour of Edge Localised Modes in improved H-mode in ASDEX Upgrade

Improved and conventional high confinement mode discharges in ASDEX Upgrade are compared with respect to H-mode pedestal properties and energy losses due to Edge Localised Modes. In both scenarios, “stiff” temperature profiles and, with few e xceptions, only small variations of the density profile shape give rise to a significant correlation between c ore and pedestal stored energy. The confinement improvement with increased heating power is accompani ed w th increasing pedestal temperature and pedestal pressure. While the electron temperature barr ier width increases with power, the density barrier width remains unchanged or even decreases. The edge pressure gradient increases with power, indicating improved edge stability with increased heating power or beta. The ELM energy loss in improved H-mode is not significantly different from that in con ve tional H-mode, although there is large scatter in both distributions.