Miracle-dz/UniFAR-FTUs huggingface dataset:
Effects of Facets of Mindfulness on College Adjustment Among First-Year Chinese College Students: The Mediating Role of Resilience

Introduction College life is a challenging stage for students to transition from adolescence to early adulthood. College students need to adjust to various problems, including those related to learning, campus life, interpersonal relationships, career selection, emotions, and self. The aim of this study was to test the associations between different facets of mindfulness, resilience, and college adjustment, as well as the mediation effect of resilience between mindfulness and college adjustment among first-year college students. Methods This survey study recruited 765 first-year college students in China. The psychological variables were assessed by the Five Facet Mindfulness Questionnaire, the Connor–Davidson Resilience Scale, and the Chinese College Student Adjustment Scale. Results It has been showed in the current study that mindfulness and resilience were positively correlated with college adjustment. Resilience significantly mediated the associations between four dimensions of mindfulness (ie, describing, acting with awareness, observing and non-reactivity) and college adjustment. Conclusion The findings support the potential importance of enhancing mindfulness and resilience to facilitate adjustment among first-year college students. Limitations and implications are discussed.
Efficacy and safety of single-inhaler triple therapy of glycopyrronium, formoterol and fluticasone in patients with COPD: a double-blind, randomised controlled trial

Background The aim of this work was to investigate the safety and efficacy of single-inhaler triple therapy with 12.5 μg glycopyrronium (GB)/12 μg formoterol fumarate (FF)/250 μg fluticasone propionate (FP), compared to 50 μg GB co-administered with a fixed dose of 12 μg FF/250 μg FP in subjects with COPD. Methods This was a phase 3, randomised, double-blind, active-control, parallel-group, noninferiority study conducted at 20 sites across India. COPD patients aged ≥40 to ≤75 years, with forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) <0.70, using mono/dual therapy with inhaled corticosteroids (ICSs), long-acting muscarinic antagonists (LAMAs), or long-acting β-agonists (LABAs) for ≥1 month, were included. Subjects were randomised 1:1 to GB/FF/FP or GB+FF/FP for 12 weeks. The primary efficacy end-point was the change from baseline in trough FEV1 at the end of 12 weeks. The study is registered with the Clinical Trials Registry of India (identifier number: CTRI/2019/01/017156). Results Between 23 March 2019 and 14 February 2020, 396 subjects were enrolled, with 198 patients each in the fixed-triple (GB/FF/FP) and open-triple (GB+FF/FP) groups. The difference in least-square mean (LSM) changes in pre-dose FEV1 from baseline at 12 weeks was noninferior between the groups (p<0.05). The LSM change from baseline in post-dose FEV1 was comparable (p=0.38). A superiority test showed comparable efficacy (p=0.12) for the difference in mean change from baseline in trough FEV1 between the groups. Adverse events (mild or moderate) were recorded in 25.3% and 24.9% of subjects in the GB/FF/FP and GB+FF/FP groups. Conclusions Fixed triple therapy with GB/FF/FP provides comparable bronchodilation and lung function improvement as open-triple therapy. It is safe and well tolerated in symptomatic COPD patients with a history of exacerbations. Airz-FF (GB/FF/FP) is the first SITT combination launched in India for COPD. Its efficacy is comparable to open-triple therapy (GB+FF/FP); and it is safe and well tolerated in symptomatic COPD patients with history of exacerbations. https://bit.ly/33MHXVv
Pathophysiological mechanisms of bradycardia in patients with anorexia nervosa

The purpose of this investigation was to examine heart rate variability (HRV), interbeat interval (IBI), and their interrelationship in healthy controls, bradycardic hyperpolarization‐activated cyclic nucleotide‐gated channel 4 (HCN4) mutation carriers, and patients with anorexia nervosa (AN). We tested the hypothesis that neural mechanisms cause bradycardia in patients with AN. Therefore, we assumed that saturation of the HRV/IBI relationship as a consequence of sustained parasympathetic control of the sinus node is exclusively detectable in patients with AN.
Measuring the absolute abundance of the microbiome by adding yeast containing 16S rRNA gene from a hyperthermophile

High‐throughput sequencing (HTS) of 16S rRNA gene amplicons provides compositional information regarding the microbial community, but not the absolute abundance of the bacteria. We aimed to develop a standardized method for quantifying the absolute abundance of bacteria in microbiome studies. To demonstrate the utility of our approach, we quantified the number of bacteria from the compositional data of the fecal and cecal microbiomes. The 16S rRNA gene of a hyperthermophile, Thermus aquaticus, was cloned into Pichia pastoris (yeast) genome, and an equivalent amount of the yeast was added to the stool and cecal samples of mice before DNA extraction. 16S rRNA gene library construction and HTS were performed after DNA extraction. The absolute abundances of bacteria were calculated using T. aquaticus reads. The average relative abundances of T. aquaticus in the five stool and five cecal samples were 0.95% and 0.33%, respectively, indicating that the number of bacteria in a cecum sample is 2.9 times higher than that in a stool sample. The method proposed for quantifying the absolute abundance of the bacterial population in this study is expected to overcome the limitation of showing only compositional data in most microbiome studies.
Does endoscopic intervention prevent subsequent gastrointestinal bleeding in patients with left ventricular assist devices? A retrospective study

BACKGROUND Patients with left ventricular assist devices (LVADs) are at increased risk for recurrent gastrointestinal bleeding (GIB) and repeat endoscopic procedures. We assessed the frequency of endoscopy for GIB in patients with LVADs and the impact of endoscopic intervention on preventing a subsequent GIB. AIM To evaluate for an association between endoscopic intervention and subsequent GIB. Secondary aims were to assess the frequency of GIB in our cohort, describe GIB presentations and sources identified, and determine risk factors for recurrent GIB. METHODS We conducted a retrospective cohort study of all patients at a large academic institution who underwent LVAD implantation from January 2011 – December 2018 and assessed all hospital encounters for GIB through December 2019. We performed a descriptive analysis of the GIB burden and the outcome of endoscopic procedures performed. We performed multivariate logistic regression to evaluate the association between endoscopic intervention and subsequent GIB. RESULTS In the cohort of 295 patients, 97 (32.9%) had at least one GIB hospital encounter. There were 238 hospital encounters, with 55.4% (132/238) within the first year of LVAD implantation. GIB resolved on its own by discharge in 69.8% (164/235) encounters. Recurrent GIB occurred in 55.5% (54/97) of patients, accounting for 59.2% (141/238) of all encounters. Of the 85.7% (204/238) of encounters that included at least one endoscopic evaluation, an endoscopic intervention was performed in 34.8% (71/204). The adjusted odds ratio for subsequent GIB if an endoscopic intervention was performed during a GIB encounter was not significant (odds ratio 1.18, P = 0.58). CONCLUSION Patients implanted with LVADs whom experience recurrent GIB frequently undergo repeat admissions and endoscopic procedures. In this retrospective cohort study, adherence to endoscopic guidelines for performing endoscopic interventions did not significantly decrease the odds of subsequent GIB, thus suggesting the uniqueness of the LVAD population. A prospective study is needed to identify patients with LVAD at risk of recurrent GIB and determine more effective management strategies.
Safety and efficacy of a feed additive consisting of l‐lysine sulfate produced by Corynebacterium glutamicum KCCM 80227 for all animal species (Daesang Europe BV)

Abstract Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of l‐lysine sulfate produced by Corynebacterium glutamicum KCCM 80227 as a nutritional feed additive for all animal species. The FEEDAP Panel concluded that the production strain C. glutamicum KCCM 80227 qualifies for the qualified presumption of safety (QPS) approach to safety assessment and is not detected in the final product. l‐Lysine sulfate produced using C. glutamicum KCCM 80227 does not pose any safety concern associated with the production strain. The additive under assessment is considered safe for the target species. When using l‐lysine sulfate, the background sulfur/sulfate content in the compound feed should be taken into account. l‐Lysine sulfate produced by C. glutamicum KCCM 80227 is safe for the consumers, users and for the environment. The additive l‐lysine sulfate is considered as an efficacious source of the essential amino acid l‐lysine for non‐ruminant animal species. For the supplemental l‐lysine to be as efficacious in ruminants as in non‐ruminant species, it would require protection against degradation in the rumen.
Current evidence and challenges of systematic therapies for adult recurrent glioblastoma: Results from clinical trials

Recurrence is a major concern for adult patients with glioblastomas (GBMs), and the prognosis remains poor. Although several therapies have been assessed, most of them have not achieved satisfactory results. Therefore, there is currently no standard treatment for adult recurrent GBM (rGBM). Here, we review the results of clinical trials for the systematic therapy of rGBM. Regorafenib, rindopepimut and neoadjuvant programmed death 1 (PD-1) inhibitors are promising agents for rGBM, while regorafenib is effective in both O6-methylguanine DNA methyltransferase (MGMT) promoter methylated and unmethylated patients. Temozolomide rechallenge and alkylating agents combined with bevacizumab can be useful for patients with MGMT methylation, and patients with isocitrate dehydrogenase (IDH) mutations or second recurrence can benefit from vocimagene amiretrorepvec (Toca 511). Some phase I trials on targeted therapy and immunotherapy have shown positive results, and results from further studies are expected. In addition to the analysis of existing clinical trial results, forthcoming trials should be well designed, and patients are encouraged to participate in appropriate clinical trials.
The Potential of Hydroxyapatite Toothpaste to Prevent Root Caries: A pH-Cycling Study

Purpose The effectiveness of a hydroxyapatite (HAP) toothpaste and a fluoride toothpaste in preventing root tissue demineralization (root caries) was compared using an established pH-cycling caries model. Materials and Methods Sixty dentin blocks were produced from the root tissue of extracted human teeth and were assigned to 3 test groups (n=20/group): 10% hydroxyapatite toothpaste (HAP), 1450 ppm fluoride toothpaste (fluoride), and artificial saliva (artsaliva). Early root caries lesions were developed in each sample by 7-day demineralization using a pH-cycling caries model. The daily cyclic treatment regimen consists of two 2-minute toothpaste-slurry treatment periods, one 6-hour acid challenge using acidified gel (pH 4.5), and then storage in remineralizing solution (artsaliva) for the rest of the time. Demineralization was assessed as the amount of mineral loss (∆z) using transverse microradiography (TMR). Pairwise comparisons (between treatments) were performed using analysis of variance (ANOVA), and then Tukey’s HSD for multiple comparisons. All p-values are considered significant if p<0.05. Results Both ANOVA and Tukey’s HSD indicated no significant (ANOVA; n=20) difference in mean ∆z among the groups, with least ∆z (±Sd) in the HAP (1117±366) compared to fluoride (1392±334) and artsaliva (1406±223). Relative to control, HAP and fluoride inhibited root demineralization by 21% and 6%, respectively. Conclusion Within the limit of the present study, the tested toothpaste containing 10% HAP is an effective root caries control toothpaste. Toothpaste containing 10% HAP was slightly more effective in preventing tooth demineralization than 1450 ppm fluoride provided as sodium fluoride. Thus, this study shows that HAP toothpastes can serve as an effective alternative to fluoride toothpastes for root caries management.
Quetiapine, Misuse and Dependency: A Case-Series of Questions to a Norwegian Network of Drug Information Centers

Purpose The second-generation antipsychotic quetiapine has been associated with misuse and dependency. We aimed to review questions to the Norwegian network of drug information centers concerning this potential drug safety problem. Methods We conducted a Boolean search in the database of the Regional Medicines Information and Pharmacovigilance Centres in Norway (RELIS) combining the indexed categories “quetiapine” and “adverse drug reaction” with the text words “misuse” or “dependency”. Question–answer pairs (Q/As) in the full-text, searchable RELIS database were defined as cases. Cases were analyzed for drug safety issues linked to use of quetiapine, including off-label use, polypharmacy and other patient risk factors. Results The search resulted in 54 cases. Forty-six cases (85%) were patient-related, and a majority came from physicians working in hospitals. Twenty-nine cases (54%) concerned patients with a history of addiction, 14 cases (26%) had polypharmacy, and off-label use of quetiapine for insomnia was identified in 14 of the cases (26%). Only three of the cases included a specific question about patient dependency of quetiapine, and these cases were all associated with insomnia. Conclusion We conclude that our case series from the Norwegian network of drug information centres reflects that quetiapine frequently involves clinical narratives of a history of addiction, polypharmacy or insomnia (off-label use). However, the case series did not reveal new information about the drug’s addictive potential.
Federated Multi-Task Learning under a Mixture of Distributions

The increasing size of data generated by smartphones and IoT devices motivated the development of Federated Learning (FL), a framework for on-device collaborative training of machine learning models. First efforts in FL focused on learning a single global model with good average performance across clients, but the global model may be arbitrarily bad for a given client, due to the inherent heterogeneity of local data distributions. Federated multi-task learning (MTL) approaches can learn personalized models by formulating an opportune penalized optimization problem. The penalization term can capture complex relations among personalized models, but eschews clear statistical assumptions about local data distributions. In this work, we propose to study federated MTL under the flexible assumption that each local data distribution is a mixture of unknown underlying distributions. This assumption encompasses most of the existing personalized FL approaches and leads to federated EM-like algorithms for both client-server and fully decentralized settings. Moreover, it provides a principled way to serve personalized models to clients not seen at training time. The algorithms' convergence is analyzed through a novel federated surrogate optimization framework, which can be of general interest. Experimental results on FL benchmarks show that our approach provides models with higher accuracy and fairness than state-of-the-art methods.
IN QUEST OF OPTIMAL INTENSITY MEASURES OF ROCKING BEHAVIOR

Rocking motion is a dynamic behavior particularly sensitive to the characteristics of the ground excitation. This study focuses on the identification of strong ground motion parameters critical to the (pure) rocking behavior. The paper formulates intensity measures (IMs) based on well-established (or slightly modified) strong ground motion parameters that can be grouped into three categories: (i) intensity-based, (ii) frequency-based and (iii) duration-based. The proposed IMs hinge on a dimensionless (orientationless) description of the rocking behavior following principles of dimensional and orientantional analysis. This study employs a suite of (natural) earthquake records and evaluates the ability of the candidate IMs to estimate the peak response rotation of different in size and slenderness freestanding rocking structures. The present analysis investigates also the need for vector-valued IMs. To assess the effectiveness of the examined IMs, this paper proposes selection criteria i.e., efficiency, sufficiency, and universality, the satisfaction of which indicates an ‘optimal’ IM. The results illustrate the remarkable correlation of the proposed duration-based IMs with the peak rocking response. Further, the analysis shows that a combination of appropriate scalar IMs, through the formulation of pertinent vector-valued IMs, leads to more efficient probabilistic seismic demand models applicable to a variety of structural configurations.
LATERAL CYCLIC MECHANICAL RESPONSE OF A GLAZED CURTAIN WALL: AN EXPERIMENTAL INVESTIGATION

In recent years, the considerable aesthetic features of the glass have led to a great use of the curtain walls in buildings. The most stringent requirements on these systems are imposed from an environmental point of view (water leakage, air permeability, thermal and acoustic insulation) to this day. However, it should be noted that glass façade is a self-supporting product, transmits loads (i.e. seismic, wind, snow) to the principal structure. Therefore, during an earthquake, they should resist to the seismic load and don’t cause economic losses or hazards for occupants and pedestrians safety. On the contrary, recent seismic events have shown the high vulnerability of glass curtain walls. Therefore, in order to investigate seismic performance of these systems, the present study proposes an experimental in-plane dynamic crescendo test performed at the laboratory of the Construction Technologies Institute (ITC) of the Italian National Research Council (CNR) on a full-scale aluminum-glass (stick system) facade. Then, a finite element model, calibrated in accordance with the experimental results, has been presented. This study aims to provide a support to researchers and/or professionals who intend to investigate similar façade systems, in order to avoid or reduce the difficult of performing experimental tests.
Scouting Technological Vis-a Vis Extension Gaps in Soybean Production in Madhya Pradesh

Soybean, an oilseed crop, is a major kharif crop in Malwa region of Madhya Pradesh, India. In fact, Madhya Pradesh is known as soybean state due to the highest acreage 5.67 million ha (55.69 %) and production 6.28 million tonnes with productivity of 1108 kg/ha, slightly lesser than the national average (1207 kg/ha). Forty six Krishi Vigyan Kendra are functional in the state and striding hard to enhance the productivity and returns from soybean cultivation since long. KVKs are engaged in identifying the reasons for gaps in the productivity at the farmers fields and searching ways for reducing the yield gaps. This study focuses on the technological interventions on soybean crop carried out by three sampled KVKs during the period from 2008-09 to 2010-11. Under frontline demonstrations, technology/ practices viz., use of improve variety (JS-93-05), seed treatment, seed inoculation, spacing 30cm, balance application of fertilizers, weed management and plant protection measure, etc were demonstrated in selected plots. The results showed 16.72 to 34.70 percent yield increase over farmer’s practice. The highest yield as 21.42 q ha-1 was recorded in the demonstrated plots, which was 27.0 percent more over the farmer’s practice (16.83 q ha-1). The extension gap ranged from 1.85 q ha-1 to 5.05 q ha-1 during the reporting period. The benefit : cost ratio of the demonstration plots and farmers plots ranged as 2.91 to 4.04 and 2.44 to 3.79, respectively.
The Utility of Phosphohistone H3 in Inter-Observer Variability of Mitotic Count in Meningioma, is There Any Benefit?

Objective: One of the most reliable and decisive histologic parameters with negative prognostic impact is tumor proliferation capacity . Quantification of mitosis in H&E stained slides could be problematic and is limited by poor reproducibility and lack of objectivity. This study was designed to evaluate inter-observer variability in mitotic count using Phosphohistone H3(PHH3). Methods: Totally, 60 specimens with histologic diagnosis of meningioma were selected including 50 grade I, 7 grdae II and 3 grade III tumors. Mitotic figures were counted both in H&E stained sections and slides prepared by immunohistochemistry using Anti-Phosphohistone H3 Anti body by three observers with various level of expertise, independently. Results: Mean mitotic count by PHH3 method was higher than H&E staining for all three observers. Observer 1 and 2 revealed good correlation in mitotic count using H&E method, while observer 3 showed disagreement with both of them. However, all of them had good correlation in mitotic count using PHH3 method (cc=0.956,0.947,0.909). Conclusion: Based on our findings, PHH3 revealed good agreement between pathologists with various level of expertise and has the capability for further contribution in meningioma grading classification and specially could be beneficial for less experienced pathologists.