Miracle-dz/UniFAR-FTUs huggingface dataset:
Association of Absolute and Relative Handgrip Strength with Prevalent Metabolic Syndrome in Adults: Korea National Health and Nutrition Examination Survey 2014–2018

Maintaining or improving muscular strength may be a key preventive strategy for metabolic syndrome (MetS). However, whether the association of handgrip strength (HGS), as a well-established marker of whole-body muscular strength, with the prevalent metabolic syndrome (MetS) varies with age stratification remains unclear. Additionally, whether absolute of relative HGS is superior to another in predicting MetS is less clear. We examined the association of both relative and absolute HGS with the prevalence of MetS in different age groups. Korean adults aged ≥19 years (n = 28,146; 55.7% female) from the Korean National Health and Nutrition Examination Survey (2014–2018) were examined. HGS was categorized using tertile split (highest, intermediate, lowest) and participants were stratified into different age groups at 10-year intervals. Multivariable logistic regression models were used to examine the association between absolute/relative HGS tertiles and MetS with adjustment for covariates. Lower odds of MetS were observed across lower absolute HGS tertiles and the associations were significant in young participants (19–29 years) in both sexes (odds ratio (OR): 0.59 (95% CI: 0.38–0.92) for intermediate and OR: 0.55 (95% CI: 0.34–0.89) for lowest in males; OR: 0.36 (95% CI: 0.20–0.65) for intermediate and OR: 0.42 (95% CI: 0.24–0.74) for lowest in females; all p < 0.05). By contrast, higher odds of MetS were observed across lower relative HGS in all age groups in both sexes (in total participants, OR: 2.32 (95% CI: 2.06–2.62) for intermediate and OR: 3.69 (95% CI: 3.27–4.16) for lowest in males and OR: 2.04 (95% CI: 1.83–2.28) for intermediate and OR: 3.28 (95% CI: 2.94–3.65) for lowest in females all p < 0.05). The associations of both absolute and relative HGS with MetS attenuated with an increase in age. Our findings suggest that poor relative HGS, as a marker of muscular strength, and not absolute HGS, may be associated with a higher risk of MetS in adults. Our findings also suggest that relative HGS may overestimate MetS in young adults.
A Modified Sliding Mode Control for a Three-Parameter Fourth-Order Chaotic Model of a Power System

This paper shows the design of a modified SMC for a three-parameter fourth-order chaotic model of a power system. The suggested approach uses Lyapunov candidate function that includes discontinuous signum function and absolute function based on fractional power of the switching surface using lower number of control inputs. After the PI switching surface has been used, a sliding mode controller is designed. It is observed that employing fractional power of the switching surface with three control input-based controller performs better in terms of lower ITAE, insignificant steady-state error, limited total variation in input, and low control energy compared to a reported work [1]. The simulation results validate the hypothesis.
On the mean profiles of radio pulsars – I. Theory of propagation effects

We study the influence of propagation effects on the mean profiles of radio pulsars using the method of wave propagation in inhomogeneous media described by Kravtsov & Orlov. This approach allows us first to take into consideration the transition from geometrical optics to vacuum propagation, the cyclotron absorption and the wave refraction simultaneously. In addition, the non-dipole magnetic field configuration, the drift motion of plasma particles and their realistic energy distribution are taken into account. It is confirmed that, for ordinary pulsars (period P ∼ 1 s, surface magnetic field B0 ∼ 1012 G) and typical plasma generation near the magnetic poles (multiplicity parameter λ = ne/nGJ ∼ 103), the polarization is formed inside the light cylinder at a distance resc ∼ 1000 R from the neutron star, the circular polarization being 5–20 per cent which is in agreement with observational data. A one-to-one correspondence between the signs of circular polarization and position angle (PA) derivative along the profile for both ordinary and extraordinary waves is predicted. Using numerical integration we now can model the mean profiles of radio pulsars. It is shown that the standard S-shape form of the PA swing can be realized for small enough multiplicity λ and large enough bulk Lorentz factor γ only. It is also shown that the value of the maximum derivative of PA, which is often used for determination of the angle between magnetic dipole and rotation axis, depends on the plasma parameters and could differ from the rotation vector model (RVM) prediction.
EXTREME PARTICLE ACCELERATION IN MAGNETIC RECONNECTION LAYERS: APPLICATION TO THE GAMMA-RAY FLARES IN THE CRAB NEBULA

The gamma-ray space telescopes AGILE and Fermi detected short and bright synchrotron gamma-ray flares at photon energies above 100 MeV in the Crab Nebula. This discovery suggests that electron–positron pairs in the nebula are accelerated to PeV energies in a milligauss magnetic field, which is difficult to explain with classical models of particle acceleration and pulsar wind nebulae. We investigate whether particle acceleration in a magnetic reconnection layer can account for the puzzling properties of the flares. We numerically integrate relativistic test-particle orbits in the vicinity of the layer, including the radiation reaction force, and using analytical expressions for the large-scale electromagnetic fields. As they get accelerated by the reconnection electric field, the particles are focused deep inside the current layer where the magnetic field is small. The electrons suffer less from synchrotron losses and are accelerated to extremely high energies. Population studies show that, at the end of the layer, the particle distribution piles up at the maximum energy given by the electric potential drop and is focused into a thin fan beam. Applying this model to the Crab Nebula, we find that the emerging synchrotron emission spectrum peaks above 100 MeV and is close to the spectral shape of a single electron. The flare inverse Compton emission is negligible and no detectable emission is expected at other wavelengths. This mechanism provides a plausible explanation for the gamma-ray flares in the Crab Nebula and could be at work in other astrophysical objects such as relativistic jets in active galactic nuclei.
Critical behavior of the two-dimensional Ising model with long-range correlated disorder

We study critical behavior of the diluted 2D Ising model in the presence of disorder correlations which decay algebraically with distance as $\sim r^{-a}$. Mapping the problem onto 2D Dirac fermions with correlated disorder we calculate the critical properties using renormalization group up to two-loop order. We show that beside the Gaussian fixed point the flow equations have a non trivial fixed point which is stable for $0.995<a<2$ and is characterized by the correlation length exponent $\nu= 2/a + O((2-a)^3)$. Using bosonization, we also calculate the averaged square of the spin-spin correlation function and find the corresponding critical exponent $\eta_2=1/2-(2-a)/4+O((2-a)^2)$.
Factors associated with the prevalence of malnutrition among adult hemodialytic patients: A two-center study in the Jeddah region, Saudi Arabia

Chronic kidney disease, one of the most common diseases in the world, is characterized by irreversible impairment of the kidney’s metabolic, excretory, and endocrine functions. During end-stage renal disease, patients require renal replacement therapy, such as hemodialysis (HD). Protein-energy wasting is a common health problem among HD patients. This study aims to assess the nutritional status of HD patients at two HD centers in Jeddah, Saudi Arabia, and to determine its associated factors. A cross-sectional study was conducted at two different dialysis centers in Jeddah, Saudi Arabia; 211 female and male HD patients. Malnutrition was recognized using the modified-subjective global assessment (M-SGA) comprising two parts: medical history and physical examination. Sociodemographic and health status for all patients were also determined. Patients were classified based on their M-SGA score into two groups: normal and malnourished. Overall, 54.5% of the participants showed malnutrition. Unemployment, low muscle strength and mass, high level of medication use, and high dialysis vintage were positively (P < .05) associated with malnutrition. In conclusion, the M-SGA score indicates a high prevalence of malnutrition among HD patients. These results show the importance of regular assessment and follow-ups for HD patients ensuring better health and nutritional status.
THE DEPENDENCE OF SUBHALO ABUNDANCE ON HALO CONCENTRATION

Hierarchical structure formation implies that the number of subhalos within a dark matter halo depends not only on halo mass, but also on the formation history of the halo. This dependence on the formation history, which is highly correlated with halo concentration, can account for the super-Poissonian scatter in subhalo occupation at a fixed halo mass that has been previously measured in simulations. Here we propose a model to predict the subhalo abundance function for individual host halos that incorporates both halo mass and concentration. We combine results of cosmological simulations with a new suite of zoom-in simulations of Milky Way-mass halos to calibrate our model. We show that the model can successfully reproduce the mean and the scatter of subhalo occupation in these simulations. The implications of this correlation between subhalo abundance and halo concentration are further investigated. We also discuss cases in which inferences about halo properties can be affected if this correlation between subhalo abundance and halo concentration is ignored; in these cases, our model would give a more accurate inference. We propose that with future deep surveys, satellite occupation in the low-mass regime can be used to verify the existence of halo assembly bias.
The Youngest Globular Clusters

It is likely that all stars are born in clusters, but most clusters are not bound and disperse. None of the many protoclusters in our Galaxy are likely to develop into long-lived bound clusters. The Super Star Clusters (SSCs) seen in starburst galaxies are more massive and compact and have better chances of survival. The birth and early development of SSCs takes place deep in molecular clouds, and during this crucial stage the embedded clusters are invisible to optical or UV observations but are studied via the radio-infared supernebulae (RISN) they excite. We review observations of embedded clusters and identify RISN within 10 Mpc whose exciting clusters have a million solar masses or more in volumes of a few cubic parsecs and which are likely to not only survive as bound clusters, but to evolve into objects as massive and compact as Galactic globulars. These clusters are distinguished by very high star formation efficiency eta, at least a factor of 10 higher than the few percent seen in the Galaxy, probably due to violent disturbances their host galaxies have undergone. We review recent observations of the kinematics of the ionized gas in RISN showing outflows through low-density channels in the ambient molecular cloud; this may protect the cloud from feedback by the embedded HII region.
Andrographolide Induces G2/M Cell Cycle Arrest and Apoptosis in Human Glioblastoma DBTRG-05MG Cell Line via ERK1/2 /c-Myc/p53 Signaling Pathway

Human glioblastoma multiforme (GBM) is one of the most malignant brain tumors, with a high mortality rate worldwide. Conventional GBM treatment is now challenged by the presence of the blood–brain barrier (BBB), drug resistance, and post-treatment adverse effects. Hence, developing bioactive compounds isolated from plant species and identifying molecular pathways in facilitating effective treatment has become crucial in GBM. Based on pharmacodynamic studies, andrographolide has sparked the interest of cancer researchers, who believe it may alleviate difficulties in GBM therapy; however, it still requires further study. Andrographolide is a bicyclic diterpene lactone derived from Andrographis paniculata (Burm.f.) Wallich ex Nees that has anticancer properties in various cancer cell lines. The present study aimed to evaluate andrographolide’s anticancer effectiveness and potential molecular pathways using a DBTRG-05MG cell line. The antiproliferative activity of andrographolide was determined using the WST-1 assay, while scratch assay and clonogenic assay were used to evaluate andrographolide’s effectiveness against the cancer cell line by examining cell migration and colony formation. Flowcytometry was also used to examine the apoptosis and cell cycle arrest induced by andrographolide. The mRNA and protein expression level involved in the ERK1/2/c-Myc/p53 signaling pathway was then assessed using qRT-PCR and Western blot. The protein–protein interaction between c-Myc and p53 was determined by a reciprocal experiment of the co-immunoprecipitation (co-IP) using DBTRG-05MG total cell lysate. Andrographolide significantly reduced the viability of DBTRG-05MG cell lines in a concentration- and time-dependent manner. In addition, scratch and clonogenic assays confirmed the effectiveness of andrographolide in reducing cell migration and colony formation of DBTRG-05MG, respectively. Andrographolide also promoted cell cycle arrest in the G2/M phase, followed by apoptosis in the DBTRG-05MG cell line, by inducing ERK1/2, c-Myc, and p53 expression at the mRNA level. Western blot results demonstrated that c-Myc overexpression also increased the production of the anti-apoptotic protein p53. Our findings revealed that c-Myc and p53 positively interact in triggering the apoptotic signaling pathway. This study successfully discovered the involvement of ERK1/2/c-Myc/p53 in the suppression of the DBTRG-05MG cell line via cell cycle arrest followed by the apoptosis signaling pathway following andrographolide treatment.
New secondary phosphate mineral occurrences and their crystal chemistry, at the Hagendorf Süd pegmatite, Bavaria

Abstract. First occurrences from the Hagendorf Süd pegmatite of the secondary phosphate minerals kenngottite, Mn32+Fe43+(PO4)4(OH)6(H2O)2; allanpringite, Fe33+(PO4)2(OH)3 ⚫ 5H2O; iangreyite, Ca2Al7(PO4)2(PO3OH)2(OH,F)15 ⚫ 8H2O; and nizamoffite, MnZn2(PO4)2(H2O)4, are reported with characterisation of their crystal chemistry and phase associations. A synchrotron single-crystal structure refinement for kenngottite shows that it has the same level of disordering (75 %/25 %) of Fe3+ in adjacent octahedra along the 5 Å axis as for type-locality kenngottite from Krásno, Czech Republic. This is explained in terms of 1 : 1 fine-scale mixing of domains of ordered kenngottite-type and souzalite-type structures. Allanpringite occurs in an unusual epitaxial relationship to associated strunzite. The epitaxy is explained by the close metrical and structural match of common planes in the two minerals, (010) for allanpringite and (100) for strunzite. Iangreyite occurs in close association with perhamite in 30 µm spheroids. The characterisation results support a paragenesis of iangreyite from perhamite by selective leaching of silica from the layer structure of perhamite and rejoining of the layers by fusion of AlO4 tetrahedra from adjacent layers into AlO2(OH)3 trigonal bipyramids.
Bond chaos in the Sherrington–Kirkpatrick model

We calculate the probability distribution of the overlap between a spin glass and a copy of itself in which the bonds are randomly perturbed in varying degrees. The overlap distribution is shown to go to a δ distribution in the thermodynamic limit for arbitrarily small perturbations (bond chaos) and we obtain the scaling behaviour of the distribution with system size N in the high- and low-temperature phases and exactly at the critical temperature. The results are relevant for the free energy fluctuations in the Sherrington–Kirkpatrick model [1].
Aggression in Women with Schizophrenia Is Associated with Lower HDL Cholesterol Levels

This study assessed the association between serum lipid levels and aggression in female patients with schizophrenia. The study included female patients with schizophrenia (N = 120). The participants were subdivided into two groups (aggressive and nonaggressive), with 60 participants in each group. Serum lipids—cholesterol, triglycerides, high-density lipoproteins (HDL cholesterol), and low-density lipoproteins (LDL cholesterol)—were determined. The clinical part of the study included an evaluation using psychiatric scales: the positive and negative syndrome scale (PANSS), the aggression subscale of the PANSS scale (PANSS-AG), and the overt aggression scale (OAS). Significant differences were only observed in HDL cholesterol levels, where aggressive subjects had significantly lower values of HDL cholesterol (t = 2.540; p = 0.012), and the representation of subjects with low cholesterol values was almost three-times higher in the group of subjects with aggression (χ2 = 7.007; p = 0.008) compared to the nonaggressive group. The nominally significant predictor for HDL cholesterol in nonaggressive and aggressive participants was the total value of the PANSS scores. In subjects with aggression, suicidality was not significantly associated with HDL cholesterol levels. Our findings suggest that lower HDL cholesterol is significantly associated with aggression in women with schizophrenia.
UNIFYING A BOXY BULGE AND PLANAR LONG BAR IN THE MILKY WAY

It has been known for sometime that the Milky Way is a barred disk galaxy. More recently several studies inferred from star count observations that the Galaxy must contain a separate, new, flat long bar component, twisted relative to the barred bulge. Here we use a simulation with a boxy bulge and bar to suggest that these observations can be reproduced with a single structure. In this simulation, a stellar bar evolved from the disk, and the boxy bulge originated from it through secular evolution and the buckling instability. We calculate star count distributions for this model at different longitudes and latitudes, in a similar way as observers have done for resolved star counts. Good agreement between the simulation and the observations can be achieved for a suitable snapshot, even though the simulation has a single boxy bulge and bar structure. In this model, part of the long bar signature is due to a volume effect in the star counts, and another part is due to choosing a snapshot in which the planar part of the boxy bulge and bar has developed leading ends through interaction with the adjacent spiral arm heads. We also provide predictions from this model for the line-of-sight velocity distributions at the longitudes with the long bar signature, for comparison with upcoming surveys.
Molecular Characterization of Vitellogenin and Its Receptor in Spodoptera frugiperda (J. E. Smith, 1797), and Their Function in Reproduction of Female

The fall armyworm Spodoptera frugiperda is a highly polyphagous invasive pest. The strong reproductive capacity is an important factor in the rapid colonization and expansion of S. frugiperda. Vitellogenin (Vg) and vitellogenin receptor (VgR) play important roles in insect reproduction. As the precursor of vitellin (Vn), Vg provides essential nutrition for embryonic development, and VgR mediates the uptake of Vg by oocytes. In this context, we cloned and characterized these two genes of S. frugiperda (SfVg and SfVgR) and evaluated their expression profiles in different developmental stages and tissues. The RNA interference experiment was used to investigate their function in vitellogenesis. The ORF values of SfVg and SfVgR were 5250 and 5445 bp, encoding 1749 and 1815 amino acid residues, respectively. The qRT-PCR results revealed that both SfVg and SfVgR were highly expressed in female adults; SfVg was specifically expressed in the fat body, whereas SfVgR was highly expressed in the ovary. In addition, the depletion of either SfVg or SfVgR hindered oocyte maturation and ovarian development, leading to a significant decrease in fecundity. The present study reveals the importance of SfVg and SfVgR in the vitellogenesis of S. frugiperda, laying a theoretical foundation for the development of pollution-free pest control strategies with SfVg and SfVgR as new targets.
In Vivo Evaluation of DMSA-Coated Magnetic Nanoparticle Toxicity and Biodistribution in Rats: A Long-Term Follow-Up

This work presents a long-term follow-up (300 days) of rats after a single intravenous injection of DMSA-coated magnetite nanoparticles (DMSA-MNP). The animals were systematically evaluated by hematological, biochemical, and ultrasound examinations, monitoring the same animal over time. In addition, oxidative stress evaluation, DMSA-MNP biodistribution, computerized tomography for ex vivo organs, and histopathology analysis were performed at the end of the experiment period. Overall, DMSA-MNP administration did not cause serious damage to the rats’ health over the course of 300 days post-administration. All animals presented hematological parameters within the normal limits, and no alterations on serum creatinine, urea, ALT, and AST were related to DMSA-MNP administration. Liver and spleen showed no important alterations in any of the examinations. The kidneys of treated animals displayed intermittent pelvis dilation at ultrasound analysis, but without damage to the organ parenchyma after 300 days. The lungs of treated animals presented a light interalveolar septal thickening, but the animals did not present any clinical respiratory symptom. Nanoparticles were not detected in the vital organs of treated animals 300 days after administration. This work represents the first assessment of the long-term effects of DMSA-MNP and goes a step further on the safety of its use for biomedical applications.
MEASURING DETAILED CHEMICAL ABUNDANCES FROM CO-ADDED MEDIUM-RESOLUTION SPECTRA. I. TESTS USING MILKY WAY DWARF SPHEROIDAL GALAXIES AND GLOBULAR CLUSTERS

The ability to measure metallicities and α-element abundances in individual red giant branch (RGB) stars using medium-resolution spectra (R ≈ 6000) is a valuable tool for deciphering the nature of Milky Way dwarf satellites and the history of the Galactic halo. Extending such studies to more distant systems like Andromeda is beyond the ability of the current generation of telescopes, but by co-adding the spectra of similar stars, we can attain the necessary signal-to-noise ratio (S/N) to make detailed abundance measurements. In this paper, we present a method to determine metallicities and α-element abundances using the co-addition of medium-resolution spectra. We test the method of spectral co-addition using high-S/N spectra of more than 1300 RGB stars from Milky Way globular clusters and dwarf spheroidal galaxies obtained with the Keck II telescope/DEIMOS spectrograph. We group similar stars using photometric criteria and compare the weighted ensemble average abundances ([Fe/H], [Mg/Fe], [Si/Fe], [Ca/Fe], and [Ti/Fe]) of individual stars in each group with the measurements made on the corresponding co-added spectrum. We find a high level of agreement between the two methods, which permits us to apply this co-added spectra technique to more distant RGB stars, like stars in the M31 satellite galaxies. This paper outlines our spectral co-addition and abundance measurement methodology and describes the potential biases in making these measurements.