Miracle-dz/UniFAR-FTUs huggingface dataset:
Bovine Piroplasma Populations in the Philippines Characterized Using Targeted Amplicon Deep Sequencing

Molecular assays and capillary electrophoresis sequencing have been used to identify parasites in livestock. The low sample capacity, which increases labor and processing time, is one drawback. Targeted amplicon sequencing (Ampliseq) uses the fast and large sample capacity platform to identify parasites in the target host, overcoming this limitation. DNA was extracted from 162 whole blood samples collected from cattle in three provinces in the Philippines. Using Illumina’s Miseq platform, the V4 hypervariable region of the piroplasma 18S rRNA gene was amplified and sequenced. The AMPtk pipeline was used to obtain distinct amplicon sequence variants (ASVs) and the NCBI BLAST non-redundant database was used to assign taxonomy. In total, 95 (58.64%) samples were positive for piroplasma. Using the AMPTk pipeline, 2179 ASVs were obtained. A total of 79 distinct ASVs were obtained after clustering and filtering, which belonged to genera Babesia (n = 58), Theileria (n = 17), Hepatozoon (n = 2), and Sarcocystis (n = 2). The ASV top hits were composed of 10 species: Babesia bovis, B. bigemina, Theileria orientalis, Babesia sp. , Hepatozoon canis, Sarcocystis cruzi, T. annulata, T. equi, T. mutans, and Theileria sp. Thung Song. The results generated in this study demonstrated the applicability of Ampliseq in detecting piroplasmid parasites infecting cattle in the Philippines.
The effects of combination-therapy of tocilizumab and baricitinib on the management of severe COVID-19 cases: a randomized open-label clinical trial

Background: Tocilizumab and baricitinib are considered standard treatments for hospitalized COVID-19 patients with an inflammatory status. However, the effects of co-administering these medications aiming for more rapid patient recovery are controversial among practitioners. The potential benefits include the rapid improvement of patients and regulation of the immune system, and the potential risks include the increased chance of serious adverse events, including infections. This study aimed to investigate the effects of co-administering these two medications on the 28-day mortality rate, other efficacy parameters, and safety issues. Methods: In this randomized open-label trial, 68 patients were recruited. The study was conducted at Dr. Masih Daneshvari Hospital during 6 months (from 21 March 2022 to 23 August 2022). Severely ill patients aged between 18 and 100 years old with confirmed COVID-19 were enrolled. The primary outcomes included the need for invasive mechanical ventilation and a 28-day mortality rate. Secondary outcomes included the need for non-invasive mechanical ventilation, the need for admission to the intensive care unit (ICU), the length of hospital stay, and the need for a second dose of tocilizumab. Safety assessments were also performed for 28 days. The data were collected from the patients’ medical records, which included age, gender, and comorbidities. Results: The 28-day mortality rate or the need for mechanical ventilation was not statistically different among the two groups (p-value = 0.49 for both outcomes). The need for non-invasive mechanical ventilation, the need for admission to the ICU, or the need for a second dose of tocilizumab and the length of hospital stay was not affected either (p-value = 1; 0.1; 0.49 and 0.9, respectively). One patient developed thrombosis in the combination group. No adverse events related to infectious complications were recorded in any groups. Conclusion: This study showed no beneficial effects of combining tocilizumab and baricitinib in managing severe COVID-19 cases. However, the need for ICU admission was meaningfully lower in the combination group. Studies with larger sample sizes are needed to confirm these results. Clinical Trial Registration: Identifier: RCT20151227025726N30M
Impact of preoperative type 2 diabetes mellitus on the outcomes of patients with gastric cancer following gastrectomy: Analysis of 834 patients using propensity score matching

The purpose of the current study was to compare the outcomes of patients with gastric cancer (GC) between the type 2 diabetes mellitus (T2DM) group and the non-T2DM group. The PubMed, Embase and Cochrane Library databases were searched from inception to March 8, 2022, to identify propensity score matching (PSM) studies that analyzed the effect of T2DM on the outcomes of patients with GC. Total complications, overall survival (OS), disease-free survival (DFS) and cancer-specific survival (CSS) were compared between the T2DM group and the non-T2DM group. A total of four PSM studies with 834 patients were included in the current study. There were 311 and 523 patients in the T2DM group and the non-T2DM group, respectively. Baseline characteristics of the two groups were adjusted with PSM in all the four studies, however, no significant difference was found in baseline characteristics (P>0.05). DFS was significantly worse in the T2DM group compared with that in the non-T2DM group [hazard ratio (HR), 1.45; 95% confidence interval (CI), 1.10-1.90; P=0.007)]. However, after pooling up the data, there was no significant difference between the T2DM group and the non-T2DM group in terms of OS (HR, 1.41; 95% CI, 0.92-2.16; P=0.11), CSS (HR, 1.29; 95% CI, 0.92-1.81; P=0.14) and total complications (odds ratio, 1.01; 95% CI, 0.64-1.60; P=0.95). Patients with GC and T2DM are associated with poor DFS. However, there were no significant differences between the T2DM group and the non-T2DM group in terms of OS, CSS and total complications.
Distinguished Effects of Interannual Salinity Variability on the Development of the Central-Pacific El Niñ Events

Abstract El Niño events in the central equatorial Pacific (CP) are gaining increased attention, due to their increasing intensity within the global warming context. Various physical processes have been identified in the climate system that can be responsible for the modulation of El Niño, especially the effects of interannual salinity variability. In this work, a comprehensive data analysis is performed to illustrate the effects of interannual salinity variability using surface and subsurface salinity fields from the Met Office ENSEMBLES (EN3) quality controlled ocean dataset. It is demonstrated that during the developing phase of an El Niño event, a negative sea surface salinity (SSS) anomaly in the western-central basin acts to freshen the mixed layer (ML), decrease oceanic density in the upper ocean, and stabilize the upper layers. These related oceanic processes tend to reduce the vertical mixing and entrainment of subsurface water at the base of the ML, which further enhances the warm sea surface temperature (SST) anomalies associated with the El Niño event. However, the effects of interannually variable salinity are much more significant during the CP-El Niño than during the eastern Pacific (EP) El Niño, indicating that the salinity effect might be an important contributor to the development of CP-El Niño events.
Combining Neural Architecture Search with Knowledge Graphs in Transformer: Advancing Chili Disease Detection

With the advancement in modern agricultural technologies, ensuring crop health and enhancing yield have become paramount. This study aims to address potential shortcomings in the existing chili disease detection methods, particularly the absence of optimized model architecture and in-depth domain knowledge integration. By introducing a neural architecture search (NAS) and knowledge graphs, an attempt is made to bridge this gap, targeting enhanced detection accuracy and robustness. A disease detection model based on the Transformer and knowledge graphs is proposed. Upon evaluating various object detection models on edge computing platforms, it was observed that the dynamic head module surpassed the performance of the multi-head attention mechanism during data processing. The experimental results further indicated that when integrating all the data augmentation methods, the model achieved an optimal mean average precision (mAP) of 0.94. Additionally, the dynamic head module exhibited superior accuracy and recall compared to the traditional multi-head attention mechanism. In conclusion, this research offers a novel perspective and methodology for chili disease detection, with aspirations that the findings will contribute to the further advancement of modern agriculture.
ATOPY IN PATIENTS WITH FAMILIAL MEDITERRANEAN FEVER INVESTIGATION OF PREVALENCE

Background: In this study we compared FMF patients with healthy controls to show the prevalence of atopy and allergic diseases. Materials and Methods: Eosinophil percentage, total IgE level, cow's milk specific IgE, egg white specific IgE, wheat flour specific IgE and respiratory function tests were evaluated in both groups. Result: Atopy was detected in 10 cases (16,4%) in study group and 5 (8,2%) cases in control group. In study group 5 patients (8,2%) and in control 2 (3,3%) patients had allergic disorder (p=0.272). White egg specific IgE was positive in study and control group in 3 (5%) and 11 cases (18%) respectively (p=0.044). Specific IgE of wheat flour and cow’s milk were similar between in control and study group. Serum total IgE level was higher in controls than study group (p=0.009). Conclusion: In this study, it was observed that the frequency of atopy and allergic diseases did not increase in FMF patients.
Weight Change and Risk of Atherosclerosis Measured by Carotid Intima–Media Thickness (cIMT) from a Prospective Cohort—Analysis of the First-Wave Follow-Up Data of the Canadian Longitudinal Study on Aging (CLSA)

To explore impact of weight change (WC) on risk of atherosclerosis measured by cIMT, 20,700 participants from the CLSA follow-up were included in analysis. WC was defined as the difference of weight measured at follow-up and baseline, then quartered into four groups (Q1–Q4). cIMT > 1.0 mm was defined as high risk for atherosclerosis. Adjusted odds ratio (OR (95% CI)) from logistic regression models were used to evaluate the association between WC and risk of atherosclerosis. At follow-up, participants had gained 0.118 kg weight, on average, and 16.4% of them were at high risk for atherosclerosis. The mean levels of cIMT were comparable between participants from Q1 to Q4. Compared to Q2 (reference), the ORs (95% CI) were 1.00 (0.86, 1.15), 1.19 (1.03,1.38), and 1.25 (1.08,1.45) for Q1, Q3, and Q4, respectively. A similar pattern was observed when analyses were conducted for ages < 65 vs. 65+ separately, but it was weaker for those aged 65+. Results from the jointed distribution analyses indicated that moderate weight loss might increase risk for atherosclerosis among participants with obese BMI at baseline, but not for those with cardiovascular event status at baseline. Weight gain, however, would increase risk for atherosclerosis regardless of cardiovascular event status, or overweight/obese BMI at baseline.
On Centromeres’ Evidential Values in Physical Cosmology

-The research combines literature research and evidence analyses for a cosmological direction in theory building. It differentiates the physical causal models from physical cosmology causalities. Centromeres are anchored with the partial evidences on the fifth cosmic force between the black hole and the white hole on NGC 3034. The fission-fusion transition mechanisms with centromeres are analyzed, analogous to the black hole and white hole asymptotic momentum. Ionization flows of the universe with regard to the origins of life is analyzed and concluded in the research
Surgeryto Detect Microemboli during Orthopedic Review of Transcranial Doppler Ultrasound

SUMMARY: Transcranial Doppler ultrasonography has been used to detect microemboli in the middle cerebral artery during orthopedic surgery. We conducted a comprehensive systematic literature review of transcranial Doppler ultrasonography in orthopedic surgery to evaluate its status in this setting. Fourteen studies were selected for qualitative analysis. The highest number of patients studied was 45; emboli were detected in all studies, occurring in 20%–100% of patients. Most embolic counts were below 10, but some high counts were noted. No study reported all the technical parameters of the transcranial Doppler ultrasonography. All studies assessed neurologic status, and 6 studies evaluated cognitive function postoperatively. No study identiﬁed an association between postoperative cognitive function and embolic count. Six studies sought the presence of right-to-left shunts.
Effect of 12-week endurance training on biochemical parameters in elite football players: A comprehensive analysis

Endurance training plays a pivotal role in football performance, shaping players’ cardiovascular fitness and metabolic adjustments. The purpose of this study is to investigate the different changes in biochemical parameters after exposure to 12 weeks of circuit training based on endurance in football. A total of fifteen elite football players, with an average age of 16.87 ± 1.13 years, an average weight of 61.87 ± 5.94 kg, and an average height of 172.82 ± 5.18 cm, participated in the study. On average, they had been training for 5.0 ± 1.0 years and had intermediate experience in national-level competitions for 4.0 ± 1.0 years. Following the initial data collection, the participants engaged in a twelve-week endurance training programme, involving one hour of daily training for four days a week. Pre-experimental designs were used in the data collection process. Further, for the analysis and extraction of data, descriptive statistics and t-tests were employed. The significance level was set at P < 0.05. Significant changes were found from baseline to post-treatment in each player’s biochemical parameters. A significant increase in HDL, haemoglobin, creatine, and RBC and a significant decrease in LDL and VLDL were observed. The findings of this study underscore the potential benefits of endurance training for elite football players, as reflected in positive alterations in various biochemical parameters. However, for more comprehensive conclusions and a deeper understanding of the broader implications. Future research is recommended with larger sample sizes, control groups, and more detailed performance outcome measurements. This research contributes to our knowledge of the physiological responses of elite football players to endurance training and the potential advantages, it offers in optimising their performance and overall health.
A review of intelligent ship marine object detection based on RGB camera

The article presents a comprehensive summary of Intelligent Ship Marine Object Detection (ISMOD) based on the RGB Camera. Marine object detection plays a pivotal role in enabling intelligent ships to acquire crucial data and security assurances for autonomous navigation. Among the various detection sensors, the RGB Camera is an informative and cost‐effective tool with a wide range of civil applications. In the beginning, the ISMOD metrics based on the RGB camera is analyzed from three significant aspects, namely accuracy, speed, and robustness. Subsequently, the latest research status and comparative overview are presented, encompassing three mainstream detection methods: traditional detection, deep learning detection, and sensor fusion detection. Finally, the existing challenges of ISMOD are discussed and future development trends are recommended. The results demonstrate that forthcoming development will predominantly concentrate on deep learning approaches, complemented by other techniques. It is imperative to advance detection performance in domains such as deep fusion, multi‐feature extraction, multi‐fusion technology, and lightweight detection architecture.
First-Line Managers’ Perceptions of Their Psychosocial Work Environment in Nursing Homes: A Qualitative Analysis of the Influence of Ownership Type

In the wake of welfare sector reforms and the increasing marketisation of eldercare services, nursing home first-line managers (FLMs) are confronted with escalating work demands within streamlined organisations. Given this background, the aim was to investigate FLMs’ perceptions of their psychosocial work environment and of differences between nursing home ownership types. Nineteen managers from three Swedish municipalities from municipal, outsourced, and private nursing homes participated in semi-structured interviews focused on job demands, job resources, and ownership differences. The FLMs’ perceptions were interpreted as forming two themes. Navigating challenges: striving to cope with demands highlighted various challenges, including recruitment, workload, and lack of organisational support. Key stressors encompassed personnel struggles, time constraints, and complex interactions. Influence of ownership dynamics on the work environment explored variation across ownership types. Private nursing home managers enjoyed more decision-making autonomy but faced more scrutiny than did municipal ones. FLMs in outsourced homes described unique stressors, notably uncertainty and increased workload due to the procurement process. These findings underscore the potential need for tailored systemic changes across different ownership types. The policy implications include enhancing communication and support in municipal homes, reducing the span of control in private homes, and revising the procurement process in outsourced homes. These insights suggest that further research outlining differences between ownership types, particularly private and outsourced nursing homes, is warranted. Such research could aid in formulating specific strategies tailored to each ownership type in order to enhance the psychosocial work environment for FLMs in nursing homes.
The Pattern of Cervical Lymph Node Metastasis and Risk Factors of Retropharyngeal Lymph Node Metastasis Based on Magnetic Resonance Imaging in Different Sites of Hypopharyngeal Carcinoma

Background: This study was to determine the patterns of regional lymph node (LN) spread and the risk factors of retropharyngeal lymph node (RPLN) metastasis based on magnetic resonance imaging (MRI) in hypopharyngeal squamous carcinoma (HPC) to improve clinical target volume (CTV) delineation. Methods: A cohort of 326 consecutive patients of HPC in a single institute were retrospectively reviewed. All patients underwent MRI prior to initial treatment, and the diagnosis based on MRI of the LN metastasis was confirmed by all radiation oncologists in the head and neck group during twice weekly chat rounds. Statistical analysis of data was using chi-square test and multivariant logistic regression model in SPSS 22.0 software. Results: The LN metastasis rate of all patients in this cohort was 90.5% (295/326). Level IIa/b and level III were the most frequently involved regions followed by level IV and retropharyngeal region. Skip metastasis only occurred in 6.4% (19/295). Univariate and multivariate analysis demonstrated that primary tumor subsites were located in the posterior pharyngeal wall ( P =0.002), bilateral cervical LN metastasis ( P =0.020), larger volume of primary gross target (GTVp, P =0.003), and larger volume of LN gross target (GTVnd, P =0.023) were significantly associated with RPLN metastasis. Conclusion: The regional LN spread of HPC follows an ordered pattern as level II is the most frequently involved area followed by level III, level IV, and RPLN. RPLN metastasis is more likely to occur in patients with primary site of posterior pharyngeal wall, large tumor burden, or bilateral neck LN metastasis. Therefore, it is highly recommended that the RPLN should be included into CTV for patients who have these risk factors.
Urdbean Leaf Crinkle Virus: A Mystery Waiting to Be Solved

Urdbean leaf crinkle disease (ULCD) affects mainly the urdbean or blackgram (Vigna mungo (L.) Hepper) causing distinct symptoms that often result in serious yield losses. It has been known to occur for more than five decades and is considered to be of viral etiology. The identity of the causal agent, often referred to as the urdbean leaf crinkle virus, is not unequivocally proved. There are few attempts to characterize the causal agent of ULCD; however, there is no unanimity in the results. Recent attempts to characterize the causal agent of ULCD using next-generation sequencing of the virome of ULCD-affected urdbean plants indicated the involvement of cowpea mild mottle virus; however, without conforming through Koch’s postulates, the etiology of ULCD remains inconclusive. Claims of different insect vectors involved in the transmission of ULCD make this disease even more mysterious. The information available so far indicates that either two different viruses are causing ULCD or a mixture of viruses is involved. The identity of the virus/es causing ULCD still remains to be unambiguously ascertained. In this review, we attempt to analyze information on the various aspects of ULCD.
Multiple Hepatic Lipoma: A Case Report of Captive Hill Mynah with Iron Storage Disease

Simple Summary The lipoma is a benign tumor consisting of mature adipocytes. Although lipomas can arise anywhere on the body, hepatic lipomas are rarely observed; thus, only a few hepatic lipoma cases are documented in veterinary medicine. According to previous research, the majority of hepatic lipomas are generally observed as solitary nodular structures. However, recently, multiple hepatic lipomas were found in a captive hill mynah. In the present case, the liver tissue from the bird exhibited not only multiple hepatic lipomas, but also excessive iron accumulation. To the best knowledge of the authors, this is the first report of multiple hepatic lipomas accompanying ISD, and herein, these unique pathological findings are reported. Abstract The present case describes multiple hepatic lipomas in a common hill mynah (Gracula religiosa). A 21-year-old female captive common hill mynah died without any notable clinical symptoms. An autopsy and histopathological examinations were conducted to determine the exact cause of death. On gross observation, the liver demonstrated a yellowish white surface color and multiple nodules indicating neoplastic lesions. Histopathological assessment found that the nodules purely comprised mature adipocytes. Furthermore, the liver exhibited an excessive accumulation of iron in hepatocytes and Kupffer cells and the infiltration of chronic inflammatory cells, suggesting iron storage disease (ISD). Based on the results, the present case was diagnosed as multiple hepatic lipomas with ISD. To the authors’ best knowledge, multiple hepatic lipomas accompanying ISD lesions have not been reported previously. Hence, the present case is the first case report of hepatic multiple lipomas with ISD in veterinary medicine.