Miracle-dz/UniFAR-FTUs huggingface dataset:
Pre-Rehabilitation Sense of Coherence as a Predictor of Symptom Change During Rehabilitation.

Sense of coherence (SOC) constitutes the key component of salutogenesis theory. It reflects individuals' confidence that their environment is comprehensible and manageable and that their lives are meaningful. Research demonstrates a strong cross-sectional relationship between SOC and mental health. However, little is known about SOC's temporal stability and its potential to predict changes in psychopathological symptom severity in different settings. The goal of the current study was to address this gap. The study sample of the two-wave longitudinal study consists of 294 patients receiving inpatient psychotherapeutic (and psychopharmacological) treatment for various psychological disorders at a German psychosomatic rehabilitation clinic. SOC (Antonovsky, 1993) and outcome measures (i.e., general mental health problems, depression and anxiety symptoms) were assessed within two days of arrival and at the end of rehabilitation (week 5/6). SOC was significantly enhanced after treatment whereas psychopathological symptoms were significantly reduced. Regression analyses revealed that pre-treatment SOC was a significant negative predictor of post-treatment symptom severity for all outcome measures even when controlling for pre-treatment symptoms. The current findings provide first evidence that SOC is a significant unique predictor of symptom change. Future studies need to further investigate longitudinal associations between SOC and mental health outcomes in different settings. This article is protected by copyright. All rights reserved.
An Improved Phenotype-Driven Tool for Rare Mendelian Variant Prioritization: Benchmarking Exomiser on Real Patient Whole-Exome Data

Next-generation sequencing has revolutionized rare disease diagnostics, but many patients remain without a molecular diagnosis, particularly because many candidate variants usually survive despite strict filtering. Exomiser was launched in 2014 as a Java tool that performs an integrative analysis of patients’ sequencing data and their phenotypes encoded with Human Phenotype Ontology (HPO) terms. It prioritizes variants by leveraging information on variant frequency, predicted pathogenicity, and gene-phenotype associations derived from human diseases, model organisms, and protein–protein interactions. Early published releases of Exomiser were able to prioritize disease-causative variants as top candidates in up to 97% of simulated whole-exomes. The size of the tested real patient datasets published so far are very limited. Here, we present the latest Exomiser version 12.0. 1 with many new features. We assessed the performance using a set of 134 whole-exomes from patients with a range of rare retinal diseases and known molecular diagnosis. Using default settings, Exomiser ranked the correct diagnosed variants as the top candidate in 74% of the dataset and top 5 in 94%; not using the patients’ HPO profiles (i.e., variant-only analysis) decreased the performance to 3% and 27%, respectively. In conclusion, Exomiser is an effective support tool for rare Mendelian phenotype-driven variant prioritization.
The Role of Impulsivity in the Association Between Posttraumatic Stress Disorder Symptom Severity and Substance Use in Male Military Veterans.

High rates of posttraumatic stress disorder (PTSD) and comorbid substance use disorder (SUD) are prevalent in military veterans. However, few studies have investigated impulsivity as a risk factor for engaging in substance use behavior for individuals who are experiencing PTSD symptoms. The present study evaluated impulsivity as a moderator of the association between PTSD symptoms and alcohol/drug use. Male military veterans (N = 106) completed self-report measures of alcohol use behavior, drug use behavior, and impulsivity. Participants also completed a structured diagnostic interview to assess for PTSD. The findings indicated that impulsivity moderated the relation between total PTSD symptoms and alcohol use, B = 0.01, p = . 035, along with associations between alcohol use and two of the symptom clusters: PTSD reexperiencing symptoms, B = 0.01, p = . 016; and PTSD avoidance/numbing symptoms, B = 0.01, p = . 029. Veterans with high levels of impulsivity were at significantly higher risk of engaging in alcohol use than veterans with low-to-average levels. Impulsivity did not potentiate the relation between PTSD hyperarousal symptoms and alcohol use nor did it moderate the association between any of the PTSD variables and drug use. Impulsivity appears to serve as a significant risk factor for alcohol use, but not drug use, for male veterans experiencing PTSD symptoms. Future studies are necessary to replicate and expand upon these findings, particularly to facilitate the development of integrated evidence-based treatments that target both alcohol use and impulsivity within the context of PTSD.
Exercise-related coping beliefs predict physical activity levels in response to naturally occurring stress: A daily diary study of college students

Abstract Objective The present study sought to examine whether beliefs about physical activity as a means of coping with stress predicted college students’ exercise levels following naturally occurring stressors. Participants: One-hundred and twenty-seven undergraduate students were recruited from psychology courses at a large, urban university in the southwestern United States. Methods: Participants completed baseline measures and daily assessments for two weeks; data were analyzed using hierarchical linear modeling. Results: Beliefs about the coping properties of physical activity significantly moderated the effects of daily stress (b = 0.19, SE = 0.09, p = .02), and combined daily and chronic stress (b = 0.01, SE = 0.01, p < .01), on students’ daily exercise. Conclusions: College students’ beliefs about physical activity are associated with changes in their daily exercise following exposure to naturally-occurring stressors. Such beliefs may be amenable to intervention to promote adaptive coping with stress and enhanced physical activity.
LyRIC indeterminate response and Immune‐mediated pseudoprogression of diffuse large B‐cell lymphoma following polatuzumab‐based salvage therapy

Additional supporting information may be found online in the Supporting Information section at the end of the article. Table S1. Clinical and laboratory data from 68 children with AML. Table S2. Summary FLT3 status and BMI1 gene expression considering the original data and the bootstrap re-sampling of APL patient data. Table S3. Summary of FLT3 status detection by polymerase chain reaction and capillary electrophoresis Data S1. Material and Methods.
Elevated interleukin‐6 and severe COVID‐19: A meta‐analysis

Interleukin-6 is an important marker of inflammation. We performed a systematic review and meta-analysis to demonstrate the association of elevated IL-6 with severe Coronavirus disease-2019 (COVID-19). A total of 9 studies were included in the systematic review and meta-analysis. Patients with severe COVID-19 had a significantly higher serum IL-6 levels compared to non-severe patients (mean difference (MD): 38.6 pg/mL, 95% CI: 24.3 - 52.9 pg/mL, p <0.001, I2 = 98.5%). On meta-regression, increasing mean IL-6 level was associated with increased mortality in patients (Coefficient (Q): 0.01, 95% CI: 0.01-0.03, p = 0.03). Given the association of elevated IL-6 with severe COVID-19 and mortality, clinicians should use this as a potential marker to recognize severe disease. IL-6 should be incorporated in a scoring system along with other inflammatory markers to risk stratify the patients for early recognition of severe disease. Our study should encourage researchers to conduct trial evaluating Anti IL-6 antibodies such as Tocilizumab to assess the efficacy in patients with severe COVID-19. This article is protected by copyright. All rights reserved.
Inflamma-miR-21 Negatively Regulates Myogenesis during Ageing

Ageing is associated with disrupted redox signalling and increased circulating inflammatory cytokines. Skeletal muscle homeostasis depends on the balance between muscle hypertrophy, atrophy and regeneration, however during ageing this balance is disrupted. The molecular pathways underlying the age-related decline in muscle regenerative potential remain elusive. microRNAs are conserved robust gene expression regulators in all tissues including skeletal muscle. Here, we studied satellite cells from adult and old mice to demonstrate that inhibition of miR-21 in satellite cells from old mice improves myogenesis. We determined that increased levels of proinflammatory cytokines, TNFα and IL6, as well as H2O2, increased miR-21 expression in primary myoblasts, which in turn resulted in their decreased viability and myogenic potential. Inhibition of miR-21 function rescued the decreased size of myotubes following TNFα or IL6 treatment. Moreover, we demonstrated that miR-21 could inhibit myogenesis in vitro via regulating IL6R, PTEN and FOXO3 signalling. In summary, upregulation of miR-21 in satellite cells and muscle during ageing may occur in response to elevated levels of TNFα and IL6, within satellite cells or myofibrillar environment contributing to skeletal muscle ageing and potentially a disease-related decline in potential for muscle regeneration.
Tracheostomy Considerations during the COVID-19 Pandemic

Objective To compile current best practices regarding tracheostomy decision making, care, and technical performance during the global COVID-19 pandemic. Data Sources Articles listed in PubMed and Google sources for up-to-date information. Review Methods All sources presenting objective evidence related to the topic were reviewed and distilled. Conclusions Tracheostomy in patients with coronavirus disease should be a rare event yet one that requires significant decision making and procedural deliberation. Indications for surgery must be balanced by risk of disease transmission to health care workers. Considerations are given to personal protective equipment, viral testing, and alternatives. Implications for Practice Otolaryngologists worldwide must be aware of these considerations to provide safe patient care without undue risk to themselves or their hospital coworkers.
Ischemic Preconditioning Attenuates Rating of Perceived Exertion But Does Not Improve Maximal Oxygen Consumption or Maximal Power Output

Abstract ter Beek, F, Jokumsen, PS, Sloth, BN, Thomas Stevenson, AJ, and Larsen, RG. Ischemic preconditioning attenuates rating of perceived exertion but does not improve maximal oxygen consumption or maximal power output. J Strength Cond Res 36(9): 2479–2485, 2022—Brief consecutive periods of limb ischemia and reperfusion, known as ischemic preconditioning (IPC), have been reported to increase maximal power output (MPO) during cycling. However, the underlying mechanisms are unclear. Therefore, the purpose of the study was to investigate the effects of IPC on MPO, maximal oxygen consumption (V̇o2max), muscle oxygenation, and rating of perceived exertion (RPE) during an incremental cycling test. Fourteen healthy young men participated in this double-blinded, randomized crossover study, involving IPC (250 mm Hg; four 5-minute cycles of ischemia) and sham (20 mm Hg) treatment followed by an incremental cycling test to exhaustion. During the cycling test, V̇o2, RPE, heart rate (HR), blood lactate (BL), and muscle oxygenation and deoxygenation (near-infrared spectroscopy) were measured. MPO, V̇o2max, HRmax, and muscle deoxygenation did not change with IPC (all p-values > 0.13). Furthermore, IPC had no significant effect on V̇o2, HR, or muscle oxygenation during the incremental cycling test (all p-values > 0.18). However, IPC attenuated RPE during cycling at 210 W (IPC: median 17.0 [interquartile range 15.3–19.0]; sham: 17.5 [17.0–19.0]; p = 0.007) and 245 W (IPC: 18.0 [17.0–18.8]; sham: 19.0 [18.0–19.8]; p = 0.011). A single session of IPC did not improve MPO, V̇o2max, or measures of oxygen consumption during the cycling test. However, IPC lowered RPE at 210 and 245 W, suggesting that IPC may attenuate the perception of effort at higher submaximal exercise intensities.
Modulatory effect of heat stress on viability of primary cultured chicken satellite cells and expression of heat shock proteins ex vivo

Abstract Satellite cells promote muscle repairing and muscle growth. Thereby the intention of the present study was to investigate the beneficial effects of heat stress at different time intervals on chicken satellite cells’ viability. Satellite cells were isolated from 1-day-old chicks and treated at two different temperatures (37 °C and 41 °C) for various time periods (6 h, 12 h, 24 h, 48 h, and 72 h). Both temperatures significantly increased cell viability after 24 h and 48 h. After 12 h, cell viability was significantly increased at 41 °C compared to 37 °C. However, more apoptotic cells were observed at end of the experiment of 41 °C compared to 37 °C. In addition, more live cells were found at early of experimental period at 41 °C than 37 °C. Additionally, protein and mRNA expression of HSP70, HP60 and HSP47 were significantly upregulated throughout the experimental period at temperature of 41 °C compared to those at 37 °C. These results indicate that cell viability and expression of heat stress related proteins/genes are induced by high temperature of 41 °C via heat stress pathway whereas activation of heat stress related proteins/genes are lower at 37 °C. Thus, 41 °C can trigger satellite cells’ viability essential for better cell survival than 37 °C at early incubation time.
The Kinematics of the Outer Galactic Disk from A and F Stars

The kinematics of stars in the outer Galactic disk is poorly known. In addition to constraining the Galactic potential, knowledge of the motions of stars throughout the disk facilitates studies of non-axisymmetric motion, such as streaming motions due to spiral arms. Understanding the kinematics of the disk in full, including the rotation law, will help to map out its structure, and set constraints on its formation and evolution. I explore the kinematics of A/F stars in two outer-disk pencil beams. I show that A stars in particular are useful probes of outer Galactic disk kinematics. The use of these relatively earlytype stars is an alternative to the ISM gas tracers and clump giants that have been commonly used in previous studies. A/F stars offer the advantage of reduced kinematic scatter and asymmetric drift as compared to the older clump giants, and can provide a much denser sampling in the outer disk than ISM gas tracers. They are bright so can be detected out to great distances, and large samples can be efficiently selected from the IPHAS r− i, r−Hα plane. The sightlines were chosen to sample the strong shear in Galactic rotation (` = 118◦), and as a control (`= 178◦). Radial velocities (RVs) and extinction-corrected spectro-photometric distances are computed for the sample of > 1300 A/F stars with the aid of MCMC parameter fitting. The rotation law measured at `= 118◦ using the RV data is sharply rising out from RG ∼ 11 kpc, going against expectations of a flat or slowly rising law. Gaia DR2 astrometry, released in April 2018, provided proper motions for the sample. On combining these with the measured RVs and spectro-photometric distances, full space motions are obtained. The Galactocentric radial, azimuthal, and vertical velocity trends are constructed without any prior assumption about the velocity field. The measured rotation curve incorporating proper motion data is flat at ` = 178◦, but remains sharply rising at ` = 118◦, albeit less so than that determined using only RV data. I consider the detailed form of the observed Galactocentric trends with specific perturbers in mind, finding no clear interpretation in terms of perturbation from the central bar or spiral arms. The variation of observed trends with longitude and distance is a reflection of the complex dynamics in our Galaxy. The methods developed in this work and the use of A stars as tracers will be used in the future for fuller exploitation via spectroscopy on forthcoming massively multiplexed wide-field spectrographs. In particular, the PTMCMC method presented will be used to analyse WEAVE survey products. Future use of these young stellar tracers will help us to understand how our Galaxy is, and came to be, how it is now.
Influence of predator–prey evolutionary history, chemical alarm‐cues, and feeding selection on induction of toxin production in a marine dinoflagellate

The dinoflagellate, Alexandrium fundyense, produces paralytic shellfish toxins and co‐occurs with populations of the copepod, Acartia hudsonica, from Maine, but not New Jersey. The hypothesis that history of co‐occurrence between predator and prey effects the ability of prey to recognize and respond to predators with increased toxin production was tested for this copepod‐alga interaction. When A. fundyense was exposed to waterborne cues released by copepods from Maine (indirect exposure) that were either starved or fed toxic cells, cell toxin quota increased by 35% compared to unexposed controls. The induced response was significantly less for cells exposed to waterborne cues of copepods from New Jersey, and induction (20%) was only elicited by this population when fed toxic cells. These results suggest that A. fundyense responded to a kairomone from copepods from Maine, but required a feeding cue from copepods from New Jersey. An increase of approximately 300% in cell toxin quota, however, occurred when cells were directly exposed to grazing, and was independent of copepod population. Evolutionary history, therefore, had no apparent effect when induction was underlain by feeding cues. In assays with a mixture of toxic and nontoxic cells, selection for the latter was evident, and also independent of copepod population. Selectivity for nontoxic cells, however, could not account for changes in cell toxin content in the mixture experiments. When A. fundyense was exposed to extracts of toxic or nontoxic Alexandrium, toxin production increased significantly (23%), suggesting modest induction by an alga‐to‐alga alarm signal.
N uptake, soil retention and loss of soil-applied 15NH415NO3 in young Fuji/M.26 apple trees with different N status

Summary Nitrogen (N) uptake, soil retention and loss of soil-applied N were studied in young apple trees with different N backgrounds. Bench-graft potted Fuji/M.26 (Malus domestica Borkh) trees were fertigated with 5, 10 or 20 mM N twice a week from June to August, and the trees were removed from soil and bare-root stored in a 2°C cold room in December of the first season. In April of the second season, the trees were washed and replanted in containers with a N-free medium (perlite:vermiculite=l:l v), and received 500 ml Hoagland’s nutrient solution without N weekly through the experiment. The trees received 15NH415NO3 at 1g per plant or no N on June 21. Four trees from each treatment were harvested at one, two and four weeks after 15N application, and 15N and total N in plant tissues and soil were analysed. N fertigation rates during the first growing season increased tree growth and N reserve levels, and N content in trees in the second year. New shoot and leaf growth in the following season was positively related to reserve N. 15N uptake increased during the four weeks after 15N application while soil 15N retention decreased. There was no significant difference in the total 15N uptake per tree. However, trees with the lowest N contents at the end of the first growing season had the highest rate of 15N uptake per unit root dry weight. Four weeks after application of 15N, tree uptake of N accounted for about 60% of applied 15N, while about 20% of the N still remained in the soil, and another 20% of the N was lost. Our results suggested that trees with lower N status are more efficient in N uptake from soil.
The effects of zinc and vitamin C supplementation on changes in height for age anthropometry index on stunting aged 24-59 months

Stunting is a physical growth disorder characterized by a decrease in the speed of growth and the impact of nutritional imbalances. Children affected by stunting up to the age of 5 years will be difficult to repair, so it will continue into adulthood and can increase the risk of offspring with low birth weight babies (LBW). Adequacy of zinc and vitamin C for growth is an important factor for children to grow well. This study aims to determine the effect of zinc and vitamin C on changes in the height of age anthropometric index. Methods: (1) A randomized pre-post test with a control group study design with a total of 70 children aged 24-59 months in the work area of ​​ Sentolo II Public Health Center (PHC) and Pengasih II PHC. (2) The provision of zinc and vitamin C as much as 5 mg for 12 weeks in the experimental group and placebo syrup in the control group. Data analysis used chi-square, independent t-test, Mann Whitney, and Spearman. The results showed that zinc and vitamin C supplementation had a significant effect on changes in the height for age anthropometry index (p = 0.001 95% CI 0.13-0.45) with a mean difference of 0.29 and height (p = 0.016 95 % CI 0.14-1.28) with a mean difference of 0.7cm. The effect is greater in children who have a lower height for age index (p = 0.00 r = -0.61). Zinc supplementation and vitamin C significantly affected children's height and height for age index.
Context-Integrated and Feature-Refined Network for Lightweight Urban Scene Parsing

—Semantic segmentation for lightweight urban scene parsing is a very challenging task, because both accuracy and efﬁciency (e.g., execution speed, memory footprint, and computation complexity) should all be taken into account. However, most previous works pay too much attention to one-sided perspective, either accuracy or speed, and ignore others, which poses a great limitation to actual demands of intelligent devices. To tackle this dilemma, we propose a new lightweight architecture named Context-Integrated and Feature-Reﬁned Network (CIFReNet). The core components of our architecture are the Long-skip Re-ﬁnement Module (LRM) and the Multi-scale Contexts Integration Module (MCIM). With low additional computation cost, LRM is designed to ease the propagation of spatial information and boost the quality of feature reﬁnement. Meanwhile, MCIM consists of three cascaded Dense Semantic Pyramid (DSP) blocks with a global constraint. It makes full use of sub-regions close to the target and enlarges the ﬁeld of view in an economical yet powerful way. Comprehensive experiments have demonstrated that our proposed method reaches a reasonable trade-off among overall properties on Cityscapes and Camvid dataset. Speciﬁcally, with only 7.1 GFLOPs, CIFReNet that contains less than 1.9 M parameters obtains a competitive result of 70.9% MIoU on Cityscapes test set and 64.5% on Camvid test set at a real-time speed of 32.3 FPS, which is more cost-efﬁcient than other state-of-the-art methods.