Miracle-dz/UniFAR-FTUs huggingface dataset:
Validation of a multisubstance online Timeline Followback assessment

The Timeline Followback (TLFB) was originally developed to assess alcohol consumption patterns (American Journal of Public Health, 86, 1996, 966) and has been increasingly modified for Web‐based use. Additionally, new modes of substance use administration have emerged, creating a need for an adaptable TLFB tool than can capture data such as cannabis product potency or prescription drug use. Our goal was to validate an online TLFB that reliably assesses a wide range of substances in greater detail.
Cx3cr1-deficient microglia exhibit a premature aging transcriptome

Gyoneva et al use RNA-seq to show that Cx3cr1-deficient microglia in young mice display a gene expression profile similar to microglia in aged mice, suggesting premature microglial aging. CX3CR1, one of the highest expressed genes in microglia in mice and humans, is implicated in numerous microglial functions. However, the molecular mechanisms underlying Cx3cr1 signaling are not well understood. Here, we analyzed transcriptomes of Cx3cr1-deficient microglia under varying conditions by RNA-sequencing (RNA-seq). In 2-mo-old mice, Cx3cr1 deletion resulted in the down-regulation of a subset of immune-related genes, without substantial epigenetic changes in markers of active chromatin. Surprisingly, Cx3cr1-deficient microglia from young mice exhibited a transcriptome consistent with that of aged Cx3cr1-sufficient animals, suggesting a premature aging transcriptomic signature. Immunohistochemical analysis of microglia in young and aged mice revealed that loss of Cx3cr1 modulates microglial morphology in a comparable fashion. Our results suggest that CX3CR1 may regulate microglial function in part by modulating the expression levels of a subset of inflammatory genes during chronological aging, making Cx3cr1-deficient mice useful for studying aged microglia.
Agriculture development and CO2 emissions nexus in Saudi Arabia

The agriculture sector may help to improve the environment of any country. The purpose of this research is to test the existence of environmental Kuznets curve (EKC) hypothesis while keeping the energy consumption and agriculture share in income into account and analyze their effects on the CO2 emissions per capita of Saudi Arabia. We test both symmetrical, asymmetrical and quadratic effects of agriculture sector on the CO2 emissions. An inverted U-shaped relationship between gross domestic product (GDP) per capita and CO2 emissions per capita is found. Hence, EKC hypothesis is validated with a turning point at GDP per capita of 77,068 constant Saudi Riyal. Further, a negative and significant effect of agriculture sector on the CO2 emissions per capita has been found both in symmetrical and asymmetrical analyses. The magnitudes of effects of increasing and decreasing agriculture share are found statistically different on the CO2 emissions, and rising agriculture share in GDP has larger effect than that of decreasing agriculture share. An inverted U-shaped relationship is also found between agriculture share in GDP and CO2 emissions per capita with a turning point at 3.22% agriculture share in GDP.
Ossification of Superior Transverse Scapular Ligament: Incidence, Etiological Factors and Clinical Relevance. -

Introduction: The classic description of superior transverse scapular ligament (STSL) is a completely non-ossified single band and should be expected on average, in three-fourth of cases. Age, mechanical load, sex and genetic factors may be responsible for ossification of STSL. Variations in the STSL and the suprascapular notch are the most recognized possible predisposing factors for suprascapular nerve entrapment.
National Instant Criminal Background Check and Youth Gun Carrying

Adolescents with access to guns pose a substantial public health risk; we sought to determine if implementing NICS changed youth gun-carrying behavior. BrightcoveDefaultPlayer10.1542/6096754413001PEDS-VA_2019-1071 Video Abstract BACKGROUND: Despite being unable to purchase firearms directly, many adolescents have access to guns, leading to increased risk of injury and death. We sought to determine if the National Instant Criminal Background Check System (NICS) changed adolescents’ gun-carrying behavior. METHODS: We performed a repeated cross-sectional study using National Youth Risk Behavior Survey data from years 1993 to 2017. We used a survey-weighted multivariable logistic regression model to determine if the NICS had an effect on adolescent gun carrying, controlling for state respondent characteristics, state laws, state characteristics, the interaction between the NICS and state gun laws, and time. RESULTS: On average, 5.8% of the cohort reported carrying a gun. Approximately 17% of respondents who carried guns were from states with a universal background check (U/BC) provision at the point of sale, whereas 83% were from states that did not have such laws (P < .001). The model indicated that the NICS together with U/BCs significantly reduced gun carrying by 25% (adjusted relative risk = 0.75 [95% confidence interval: 0.566–0.995]; P = .046), whereas the NICS independently did not (P = .516). CONCLUSIONS: Adolescents in states that require U/BCs on all prospective gun buyers are less likely to carry guns compared with those in states that only require background checks on sales through federally licensed firearms dealers. The NICS was only effective in reducing adolescent gun carrying in the presence of state laws requiring U/BCs on all prospective gun buyers. However, state U/BC laws had no effect on adolescent gun carrying until after the NICS was implemented.
Prevalence Of Anxiety And Depression Among Doctors Working In A Private Hospital In Pakistan

Objectives: Anxiety and depression among doctors may negatively affect quality of patient care, patient safety, and professionalism. Despite the potentially serious personal and professional consequences of depression, there are very limited researches done on depression among Pakistani doctors. Therefore this study was aimed to determine the prevalence of anxiety and depression among doctors in a private teaching hospital in Pakistan. Method: This was a cross-sectional survey conducted in a tertiary care teaching hospital in Pakistan. The Self-Reporting Questionnaire for Anxiety and Depression (SRQ 20) Scale was administered to a sample of 300 medical doctors. Chi-square test and multiple regressions were used for data analysis. Results: Anxiety and Depression among doctors was measured to be 27.3 % (95% CI: 22.3, 32.4) in our study. Conclusion: More than one quarter of our doctors are suffering from anxiety and depression but this subject is fairly neglected in Pakistan and more studies should be conducted to collect more validated information on this matter. ASEAN Journal of Psychiatry, Vol.13(1): January - June 2012: XX XX.
Prevalence and Treatment of Mental Health and Substance Use Problems in the Early Emerging Adult Years in the United States

Onset of most mental disorders occurs by the mid-20s, yet studies of mental health (MH) status are limited for younger adults (YAs) aged 18–25. The objectives were to determine YAs’ rates of MH and substance use (SU) disorders, treatment, and sociodemographic disparities. To determine relative vulnerability and unmet need, overall rates were compared between ages 18–25 and 26–34. Using the 2010 National Survey on Drug Use and Health (n = 25,216), we estimated past-year serious psychological distress, major depressive episode, alcohol and drug abuse/dependence, and treatment for both age groups and examined YA subgroup differences (gender, race/ethnicity, income, education, and insurance). YAs had higher prevalence of MH and SU disorders, but lower treatment rates than older adults. YA females had higher MH but lower SU disorder rates than males. Other sociodemographic disparities were noted. Efforts to improve YAs’ MH status are necessary to foster a successful transition to adulthood.
Effects of Inotropes on the Mortality in Patients With Septic Shock

Background: Although surviving sepsis campaign guidelines recommend the use of inotropes in the presence of myocardial dysfunction, the effects of inotropes, including epinephrine, dobutamine, and milrinone, on in-hospital mortality in patients with septic shock remains unclear. Materials and Methods: We conducted an international,2-center, retrospective cohort study. The Cox proportional hazards regression model with time-varying covariates was used to investigate whether epinephrine, milrinone, or dobutamine reduces in-hospital mortality in patients with septic shock. Sensitivity analysis was performed using propensity score matching. The primary outcome was in-hospital mortality. The secondary outcome included atrial fibrillation (Afib) with a rapid ventricular response (RVR) in the intensive care unit (ICU) and ICU-free days. Results: A total of 417 patients with septic shock were included, 72 (17.3%) of whom received inotropes. The use of epinephrine and dobutamine was associated with significantly higher in-hospital mortality (epinephrine, hazard ratio [HR]: 4.79, 95% confidence interval [CI]: 2.12-10.82, P = .001; dobutamine, HR: 2.53, 95% CI: 1.30-4.95, P = .046). The effects of epinephrine and dobutamine were time- and dose-dependent. The use of milrinone was not associated with increased mortality (HR: 1.07, 95% CI: 0.42-2.68, P = .345). The use of epinephrine, dobutamine, and milrinone was associated with significantly increased odds of Afib with RVR (epinephrine, odds ratio [OR]: 3.88, 95% CI: 1.11-13.61, P = .034; dobutamine, OR: 3.95, 95% CI: 1.14-13.76; and milrinone, OR: 3.77, 95% CI: 1.05-13.59). On the other hand, the use of epinephrine, dobutamine, and milrinone was not associated with less ICU-free days (epinephrine, adjusted OR: 0.30, 95% CI: 0.09-1.01, P = .053; dobutamine, adjusted OR: 0.91, 95% CI: 0.29-2.84; and milrinone, adjusted OR: 0.60, 95% CI: 0.19-1.87). Conclusion: The present study showed that the use of epinephrine and dobutamine was associated with significantly increased in-hospital mortality in patients with septic shock. These effects were both time- and dose-dependent. On the other hand, the use of milrinone was not associated with increased in-hospital mortality.
Protective impacts of circular RNA VMA21 on lipopolysaccharide-engendered WI-38 cells injury via mediating microRNA-142-3p.

CircRNA derived from vacuolar ATPase assembly factor (circVMA21) is a newly-researched circRNA, which is reported to adjust the degeneration of intervertebral disc. But, function of circVMA21 in infantile pneumonia is yet to be explored. The research surveyed the role of circVMA21 in lipopolysaccharide (LPS)-caused WI-38 cell inflammatory injury. LPS (10 μg/ml, 12 hr) was exploited to arouse WI-38 cell inflammatory injury. Subsequently, the mediatory impacts of microRNA (miR)-142-3p and circVMA21 in LPS-evoked cell injury were detected after transfection with the inhibited or overexpressed vectors. In above processes, cell behaviors of cell viability, apoptosis, and pro-inflammatory factors were monitored. NF-κB and JNK pathways were elucidated to showcase the feasible molecular mechanisms. Results displayed that LPS engendered WI-38 cell inflammatory injury was alleviated as well as activated NF-κB and JNK pathways was interdicted by miR-142-3p suppression. Importantly, restrained miR-142-3p expression was discovered in WI-38 cells after overexpressing circVMA21. Moreover, overexpressed circVMA21 exerted the similar functions as miR-142-3p suppression in LPS-triggered WI-38 cell injury. But, the influence was clearly reversed by miR-142-3p overexpression. Hindered NF-κB and JNK pathways caused by overexpressed circVMA21 was also crippled by miR-142-3p overexpression. The research discolsed that circVMA21 protected WI-38 cells to resist LPS-triggered inflammatory injury via miR-142-3p-NF-κB/JNK axis.
Outcome of Patients With Prior Stroke/Transient Ischemic Attack and Acute Coronary Syndromes

The association between prior stroke/transient ischemic attack (TIA) and clinical outcomes in patients with acute coronary syndrome (ACS) has not been well explored. We evaluated the impact of prior stroke/TIA on this specific patient population. We conducted an international multicenter study including 15 401 patients with ACS from the Bleeding Complications in a Multicenter Registry of Patients Discharged With Diagnosis of Acute Coronary Syndrome registry. They were divided into 2 groups: patients with and without prior stroke/TIA. The primary end point was death at 1-year follow-up. Prior stroke/TIA was associated with higher rate of 1-year death (8.7% vs 3.4%; P < .001). It was an independent predictor of 1-year death even after adjustment for confounding variables (odds ratio, 1.705; 95% confidence interval, 1.046-2.778; P = .032). Besides, patients with prior stroke/TIA had significantly increased 1-year reinfarction (5.6% vs 3.8%, P = .015), in-hospital bleeding (8.7% vs 5.8%, P < .001), and 1-year bleeding (5.2% vs 3.0%, P < .001). No difference of antithrombotic therapies or dual antiplatelet therapy (DAPT) types on outcomes was observed in patients with prior stroke/TIA. Prior stroke/TIA was associated with higher 1-year death for patients with ACS who underwent percutaneous coronary intervention. No benefits or harms were observed with different antithrombotic therapies or DAPT types in these patients.
Into the bloom: Molecular response of pelagic tunicates to fluctuating food availability

The planktonic tunicates appendicularians and thaliaceans are highly efficient filter feeders on a wide range of prey size including bacteria and have shorter generation times than any other marine grazers. These traits allow some tunicate species to reach high population densities and ensure their success in a favourable environment. However, there are still few studies focusing on which genes and gene pathways are associated with responses of pelagic tunicates to environmental variability. Herein, we present the effect of food availability increase on tunicate community and gene expression at the Marquesas Islands (South‐East Pacific Ocean). By using data from the Tara Oceans expedition, we show that changes in phytoplankton density and composition trigger the success of a dominant larvacean species (an undescribed appendicularian). Transcriptional signature to the autotroph bloom suggests key functions in specific physiological processes, i.e., energy metabolism, muscle contraction, membrane trafficking, and proteostasis. The relative abundance of reverse transcription‐related Pfams was lower at bloom conditions, suggesting a link with adaptive genetic diversity in tunicates in natural ecosystems. Downstream of the bloom, pelagic tunicates were outcompeted by copepods. Our work represents the first metaomics study of the biological effects of phytoplankton bloom on a key zooplankton taxon.
Pharmacodynamic and pharmacokinetic profile of SM‐1, a triple‐drug combination to increase total sleep time

The primary objective was to characterize the pharmacokinetics and pharmacodynamics of SM‐1 after administration of a single oral dose to healthy volunteers in a placebo‐controlled double‐blind trial of daytime sedation. Secondary objectives were to determine the onset, duration, and offset of the sedative effects using subjective and objective measures of sedation. Safety and tolerability of SM‐1 were also investigated.
Critical Roles of “J‐Hospitalist”

The term “Hospitalist” has become very popular in USA already, ever since this concept was first introduced in 1996. The critical role of the hospitalist has been well‐recognized among all of the US hospitals and it is clearly distinct from the traditional model of “hospital patient care” provided by primary care physicians. Recently, the concept of “Hospitalist” has been introduced in Japan, and there is increasing recognition of it as a “new subspecialty”. However, the role of this newly emerging physician's group is not as clear as the one in USA, and the adoption rate has been still slow in Japan. It would be worthwhile to review the history of hospitalist movement in US and its evolution to help better understand the concept. Then, I would like to define the roles of “J‐Hospitalist” in this article.
Top-Down Feedback Controls the Cortical Representation of Illusory Contours in Mouse Primary Visual Cortex

Visual systems have evolved to recognize and extract features from complex scenes using limited sensory information. Contour perception is essential to this process and can occur despite breaks in the continuity of neighboring features. Such robustness of the animal visual system to degraded or occluded shapes may also give rise to an interesting phenomenon of optical illusions. These illusions provide a great opportunity to decipher neural computations underlying contour integration and object detection. Kanizsa illusory contours have been shown to evoke responses in the early visual cortex despite the lack of direct receptive field activation. Recurrent processing between visual areas has been proposed to be involved in this process. However, it is unclear whether higher visual areas directly contribute to the generation of illusory responses in the early visual cortex. Using behavior, in vivo electrophysiology, and optogenetics, we first show that the primary visual cortex (V1) of male mice responds to Kanizsa illusory contours. Responses to Kanizsa illusions emerge later than the responses to the contrast-defined real contours in V1. Second, we demonstrate that illusory responses are orientation-selective. Finally, we show that top-down feedback controls the neural correlates of illusory contour perception in V1. Our results suggest that higher-order visual areas may fill in the missing information in the early visual cortex necessary for illusory contour perception. SIGNIFICANCE STATEMENT Perception of the Kanizsa illusory contours is impaired in neurodevelopmental disorders such as schizophrenia, autism, and Williams syndrome. However, the mechanism of the illusory contour perception is poorly understood. Here we describe the behavioral and neural correlates of Kanizsa illusory contours perception in mice, a genetically tractable model system. We show that top-down feedback controls the neural responses to Kanizsa illusion in V1. To our knowledge, this is the first description of the neural correlates of the Kanizsa illusion in mice and the first causal demonstration of their regulation by top-down feedback.
Exploring the needs of people with dementia living at home reported by people with dementia and informal caregivers: a systematic review and Meta-analysis

Abstract Objectives To provide prevalence estimates of needs of people with dementia living at home, and to determine sources of variation associated with needs for this population. Method A systematic review and meta-analysis was performed searching CINAHL, MEDLINE, PsycINFO and ASSIA databases. Following quality checks, random effects meta-analysis produced prevalence estimates for needs reported by people with dementia and by their informal caregivers. Fixed effects models were undertaken to compare caregiver and person with dementia reported needs. Heterogeneity was explored through sensitivity analysis. The study protocol was registered with Prospero #CRD42017074119 Results Six retrieved studies published between 2005 and 2017 including 1011 people with dementia and 1188 caregivers were included in the analysis. All data were collected using Camberwell Assessment of Need for the Elderly. Prevalence estimates are provided for 24 needs reported by participants in The Netherlands, United Kingdom, Poland, Ireland, Germany, Norway, Portugal, Italy and Sweden. Most prevalent needs reported by people with dementia were Memory 0.713 [95% CI 0.627, 0.791]; Food 0.706 [95% CI 0.547, 0.842]; Household activities 0.677 [95% CI 0.613, 0.738]; and Money 0.566 [95% CI 0.416, 0.711]. Caregivers reported greater prevalence than people with dementia did for 22 of 24 needs, although the priority ranking of needs was similar. Exploration of heterogeneity revealed that people with young onset dementia were the major source of variation for 24 out of 48 analyses. Conclusion Increased understanding of prevalence of needs of people with dementia and associated heterogeneity can assist in planning services to meet those needs.
The Self‐Construal Scale: A Potential Tool for Predicting Subjective Well‐Being of Individuals With Autism Spectrum Disorder

Despite accumulating evidence that culture shapes the symptoms of autism spectrum disorder (ASD), no studies have yet applied the Self‐Construal Scale to individuals with ASD. We compared the self‐construals (measured using the Self‐Construal Scale) of 31 high‐functioning Japanese individuals with ASD with those of 60 typically developing (TD) individuals. We also examined how the self‐construals of individuals with ASD related to their intelligence quotient, adverse childhood experiences, attention deficit hyperactivity disorder, ASD symptoms during adulthood and preschool years, and subjective well‐being. Individuals with ASD were more likely to display independent self‐construals than were TD individuals; unexpectedly, however, a substantial proportion of individuals with ASD (43.8%) displayed relatively interdependent self‐construals. Among individuals with ASD, self‐construals were significantly associated with ASD symptoms during preschool years, and with satisfaction of the need for autonomy and frustration of the need for relatedness. Evaluating self‐construals can help predict the subjective well‐being of high‐functioning individuals with ASD. Moreover, the Self‐Construal Scale may be useful for understanding the heterogeneous phenotypes of ASD, based on its association with autistic symptoms during preschool years, suggesting that the scale is a potential tool to develop efficient interventions for high‐functioning individuals with ASD. Autism Res 2020, 13: 947‐958. © 2019 International Society for Autism Research, Wiley Periodicals, Inc.
Close Friends' Drinking and Personal Income as Mediators of Extreme Drinking: A Prospective Investigation.

OBJECTIVE This study examined longitudinal associations between college attendance, residence on- or off-campus, and work status during the first 2 years after high school with extreme binge drinking at 4 years after high school and tested peer drinking and personal income at 3 years after high school as mediators. METHOD Data were drawn from Waves 4-7 of the NEXT Generation Health Study (n = 2,081). Multinomial logistic regressions and mediation analyses were conducted. Extreme binge drinking was measured using the largest number of drinks on a single day in the past year. RESULTS Univariate analyses indicated that attending university, living on campus, and working more than 30 hours at any point during the first 2 years after high school were associated with increased risk of drinking two to three times above the binge drinking threshold (relative risk ratios [RRR] ranged from 1.79 to 5.70). In multivariate analyses, dropping out of university was associated with drinking two times above the binge drinking threshold (RRR = 4.88), whereas living on campus (RRR = 4.54) and working more than 30 hours (RRR = 5.26) were associated with increased risk of drinking three times above the binge drinking threshold. Close friends' drinking and personal income were significant mediators. CONCLUSIONS Living on campus and working more than 30 hours per week during the first 2 years after high school increased risk for drinking three times above the binge drinking threshold at 4 years after high school.