Miracle-dz/UniFAR-FTUs huggingface dataset:
TLR4 Promotes and DAP12 Limits Obesity‐Induced Osteoarthritis in Aged Female Mice

Aging and female sex are the strongest risk factors for nontraumatic osteoarthritis (OA); whereas obesity is a modifiable risk factor accelerating OA. Prior studies indicate that the innate immune receptor toll‐like receptor 4 (TLR4) mediates obesity‐induced metabolic inflammation and cartilage catabolism via recognition of damage‐associated molecular patterns and is increased with aging in OA joints. TLR4 responses are limited by innate immunoreceptor adapter protein DNAX‐activating protein of 12kDA (DAP12). We undertook this study to test the hypothesis that TLR4 promotes, whereas DAP12 limits, obesity‐accelerated OA in aged female mice. We fed 13‐ to 15‐month‐old female WT, TLR4 KO, and DAP12 KO mice a high‐fat diet (HFD) or a control diet for 12 weeks, and changes in body composition, glucose tolerance, serum cytokines, and insulin levels were compared. Knee OA was evaluated by histopathology and μCT. Infrapatellar fat pads (IFPs) were analyzed by histomorphometry and F4/80+ crown‐like structures were quantified. IFPs and synovium gene expression were analyzed using a targeted insulin resistance and inflammation array. All HFD‐treated mice became obese, but only WT and TLR4 KO mice developed glucose intolerance. HFD induced cartilage catabolism in WT and DAP12 KO female mice, but not in TLR4 KO mice. Gene‐expression analysis of IFPs and synovium showed significant differences in insulin signaling, adipokines, and inflammation between genotypes and diets. Unlike young mice, systemic inflammation was not induced by HFD in the older female mice independent of genotype. Our findings support the conclusion that TLR4 promotes and DAP12 limits HFD‐induced cartilage catabolism in middle‐aged female mice. © 2018 The Authors JBMR Plus published by Wiley Periodicals, Inc. on behalf of American Society for Bone and Mineral Research.
Reproductive Endocrinopathies In Nigerian Males with Zero and Three or More Metabolic Syndrome Components

Childlessness has adverse social, psychological and economic impact on affected couples. The contributions of males to infertility account for 40%. Hypogonadism in males has been associated with metabolic syndrome (MS). Although endocrinopathies have been observed in infertile men, similar data in males with MS in the general population is sparse. This study is therefore aimed at evaluating the endocrinopathies in Nigerian males with zero (ZMS) and MS. Sixty-seven male participants aged 18 - 70 years were purposely enrolled for this study. Fifty two males had ZMS (control) while 15 males had MS. Demography, sexual history, blood pressure, anthropometry were obtained by standard methods. Fasting plasma glucose, triglyceride and high density lipoprotein cholesterol were determined by enzymatic methods. Sex and pituitary hormones were determined by ELISA. Data analysed were statistically significant at p < 0.05. The MS group 8 (53.3%) had significantly more males with hypogonadism than the controls 2 (23.1%) (p<0.05). Compensatory hypogonadism and suboptimal hypogonadism are the most common endocrinopathies in controls and MS group. 9 (60%) and 5 (33%) of males in the MS group were overweight and obese respectively while 2 (3.8%) and 6 (11.5%) of controls were underweight and overweight. FSH had a direct relationship with age in eugonadal controls and hypogonadal males with MS while LH had an inverse relationship with age in eugonadal males in the MS group. Endocrinopathies are prevalent in Nigerian men irrespective of their metabolic status or age
Pathological findings of experimental Aeromonas hydrophila infection in Nile tilapia (Oreochromis niloticus)

Bu calismada; intraperitoneal olarak Aeromonas hydrophila ile enfekte edilen Nil tilapyalarinda (Oreochromis niloticus), enjeksiyonu izleyen 1. , 2. , 3. , 5. ve 7. gunlerdeki klinik bulgular ile otenaziyi takiben yapilan nekropsiler sonrasinda doku ve organlarda gozlenen patolojik bulgularin, makroskobik ve mikroskobik duzeyde incelenerek degerlendirilmesi amaclandi. Klinik olarak halsizlik, istahizlik, yuzeye yakin yuzme, renkte koyulasma ile yuzgec diplerinde hiperemi ve erime gibi bulgular gozlendi. Nekropside karacigerin sarimsi kahverenkli oldugu ve kivaminin gevreklesip, uzerinde kanama ve boz beyaz odaklar gozlendi. Safra kesesinin zumrut yesili renkli safra sivisiyla gergin bir sekilde dolu oldugu dikkati cekti. Bobrekte ve kalpte kanama odaklari gozlenirken, bagirsak lumenlerinin sarimtirak renkli, mukuslu sivi ile dolu oldugu izlendi. Histopatolojik olarak karacigerde dejeneratif degisiklikler, sitoplazmalarinda yag vakuolleri ve lenfosit infiltrasyonu ile hepatosit ve pankreas hucrelerinde fokal nekroz gozlendi. Bobrekte, parankim dejenerasyonu, tubul epitellerinde nekroz ve fokal lenfosit infiltrasyonu goruldu. Deri, dalak, solungac ve gozlerde belirgin bir bulgu gozlenmedi. Karaciger, bobrek ve kalpte gerek makroskobik gerekse de mikroskobik duzeyde hemorajilerin ve lenfosit infiltrasyonunun yogun olarak gozlenmesi visseral bir hemorajik septisemi tablosu cizmektedir. Bu baglamda mevcut calisma suresince gozlenen klinik, makroskobik ve mikroskobik bulgular genel itibariyle diger tatli su baliklarinda sekillenen A. hydrophila enfeksiyonlarindaki temel bulgularla benzerlik gosterdi
Testican 1 (SPOCK1) and protein tyrosine phosphatase, receptor type S (PTPRS) show significant increase in saliva of tobacco users with oral cancer

Objectives: To identify potential candidate proteins which are secretory in nature and present at a higher abundance in oral cancer patients with tobacco habits. Methods: Conditioned media of tobacco-treated and -untreated non-neoplastic oral keratinocytes were analyzed using iTRAQ-based mass spectrometry. Hypersecreted proteins; SPARC (osteonectin), cwcv and kazal like domains proteoglycan 1 (SPOCK1); prosaposin (PSAP); and protein tyrosine phosphatase, receptor type S (PTPRS) were validated by enzyme-linked immunosorbent assay (ELISA) using saliva samples from oral cancer patients who are tobacco users. Results: Proteomic analysis of tobacco-treated and -untreated cells led to the identification of 2873 proteins. Among these, 378 proteins showed high abundance and 253 proteins showed low abundance (2-fold cutoff) in conditioned-media of tobacco-treated cells. ELISA-based validation showed significantly higher levels of SPOCK1, PSAP, and PTPRS in oral cancer patients with tobacco chewing habits compared to healthy controls. However, PSAP showed low specificity compared to SPOCK1 and PTPRS. Conclusions: This study indicates significantly increased levels of SPOCK1, PSAP, and PTPRS in saliva of oral cancer patients with tobacco habits. These protein biomarkers might be useful to identify tobacco users with high risk of developing oral cancers.
Immigrants Psychopathology: Emerging Phenomena and Adaptation of Mental Health Care Setting by Native Language

Mental health of immigrants is an important social and clinical issue. Immigrants may report higher rates of mental disorders and lower levels of use of mental health service with respect to natives. The aim of the present work is to review recent findings of the psychopathology of immigrants and analyze how to adapt the mental care settings through the use of mother tongues. We searched the literature to individuate and review the most recent scientific articles focused on the psychopathology of immigrants realized in Europe. Moreover, we summarized the guidelines about immigrants mental health care and we focused on the barriers caused by language. We individuated 15 papers reporting data about mental disorders among immigrants and the related risk and protective factors. The articles reported information about psychosis, depression, anxiety, post-traumatic stress disorder, somatization and suicide rates. Risk and protective factors are individuated mainly among social factors (e.g. ethnic density effect, hosting countries' policies). Furthermore, immigrants encounter language barriers in the use of mental care services. The realization of cross-cultural training and the development of a working alliance between clinicians and interpreters resulted to be effective solutions even if these interventions are not frequently implemented. The extent of migratory flows and the related difficulties experienced by immigrants require attention and well-informed interventions. The high rates of incidence of mental disorder and the strict number of services who implement interventions taking into accounts fundamental aspect as language show that there is still a lot to do.
An osseous lesion in the maxillary sinus—Tumour or tumour‐like?

In the bioarchaeological analysis of burials from a medieval graveyard at Hettstedt, Central Germany, a male skeleton of about 40 to 50 years at death with an unusual bony structure in the left maxillary sinus was discovered. Macroscopic examination exhibited a balloon-shaped osseous lesion with solid cortical surface 2.5 × 1.5 cm in size. Micro-CT scans revealed trabecular structures around a central cavity. The margins of the osseous lesion were well defined without infiltration of normal maxillary bone tissue. The histopathological analysis showed the presence of lamellar and woven bone. The structure and localisation of the tumour-like lesion suggest that the formation was the result of chronic inflammation and that chronic dental sinusitis seems to have triggered a large reactive ossification.
ANALISIS HUBUNGAN FAKTOR EKSOGEN DAN ENDOGEN TERHADAP KEJADIAN DERMATITIS AKIBAT KERJA PADA PEKERJA PENYAMAKAN KULIT PT. ADI SATRIA ABADI PIYUNGAN, BANTUL

Occupational dermatitis is skin disorders caused by contact with certain substances in the workplace. There are exogenous factors and endogenous factors which affects occupational dermatitis. PT. Adi Satria Abadi is an industry of leather tanning that requires dozens of chemicals in every process. This research aims to analyze the relationship of exogenous factors (working period, number of chemical type, mechanical factors) and endogenous factors (age, personal hygiene, personal protective equipment) with occupational dermatitis at PT. Adi Satria Abadi. The research is conducted analytically with cross sectional approach and explanatory research. The sample involved in this research is total population of wet production are 48 workers. The independent variable data was collected by questionnaire by respondent and occupational dermatitis data based on doctor medical check up. According to the result of research using Chi-Square test showed that the related variables with occupational dermatitis were number of chemical type (p-value = 0,001), mechanical factors (p-value = 0,001), personal hygiene (p-value = 0,001), and the type of work section (p-value = 0,001). While unrelated variables with occupational dermatitis were working period, age, and personal protective equipment.
DETERMINATION OF ABSORBED DOSES FROM VARIOUS RADIOGRAPHICS TECHNIQUES REQUIRED FOR DENTAL IMPLANTS

The diagnostic and treatment benefits of various radiographic techniques, including those used routinely for dental implants, need to be evaluated against the complications and exposure risks involved. The aims of this study were to measure the amount of ionizing radiation absorbed by various critical tissues of the body in order to determine the risks of a radiographic procedure and to compare the amount of radiation absorbed by various tissues during radiographic procedures for dental implants. This in vitro study was performed on a humanlike X-ray phantom head using lithium thermo-luminescent dosimeters. The amount of radiation absorbed by critical tissues was more during the generation of a CT scan as compared to the use of linear tomography. The absorbed dose using these two techniques was more than when panoramic radiography was used. Organs defined as critical in this study were the eyes, thyroid glands, salivary glands, brain, bone marrow and skin. The amount of radiation absorbed by the thyroid gland during a mandibular CT scan was relatively high and therefore the use of a protective collar is recommended. The amount of radiation absorption in the parotid glands was more than the other two major salivary glands and also more than all other critical organs during a mandibular CT scan, an anterior and posterior linear tomographic survey or while taking a panoramic radiograph. The maximum amount of absorption in the parotid gland was in the maxilla CT, insignificant in relation to 10 grays, the dose resulting in acute inflammation of the gland. The maximum amount of radiation absorbed in the skin was during a mandibular CT scan which was lower than the dose resulting in erythema. The maximum amount of radiation absorbed was in during a mandibular CT scan.
Effect of Five Weeks Circuit Resistance Training with Garlic Supplementation on Serum Levels of Adiponectin in Over Weight Female

Background: Obesity and Metabolic Disorders is one of the risk factors for health in the world. Physical activity and herbal supplements is the research topic in the field of health and reducing obesity. Objective: The purpose of this study was to compare the effect of five weeks circuit resistance training with garlic supplementation on serum levels of adiponectin in over weight female. Methods: In a double-blind trial quasi-experimental design, 32 healthy overweight women were selected and randomly divided into following four groups: Placebo, supplement, training and placebo and training and supplement groups. The experimental subjects received circuit resistance training was performed three times a week. All groups were given 1000 mg garlic supplements or placebo for five weeks in two doses of 500 mg daily. Anthropometric indices, and blood sampling were measured before and after five weeks of circuit resistance training. Results: After five weeks, levels of adiponectin in serum increased in resistance training group with garlic with compared to other groups, but this increase was not statistically significant (p=0.123) also body weight did not show significant difference (P=0.99). Conclusion: Based on the results suggested that more research investigate effect of garlic supplementation with resistance exercise on weight loss and serum adiponectin levels and other indicators associated with obesity in obese women. Keywords: Adiponectin, Garlic supplement, Resistance training
The effect of providing information about the patient’s condition on the anxiety level of the family members of hospitalized patients with traumatic brain injury

Article type: Original Article Received: Mar. 2018 Accepted: May 2018 e-Published: 3 Jul. 2018 Corresponding author: Fatemeh Abdoli e-mail: abdoli_f@yahoo.com Background & Aim: Anxiety is one of the most common psychiatric disorders in the family of patients with traumatic brain injury. This study aimed to determine the effect of providing information about the patient’s condition on the anxiety level of the family members of hospitalized patients with traumatic brain injury. Methods & Materials: This quasi-experimental study was conducted on 90 family members of traumatic brain injury patients admitted to Shahid Bahonar hospital in Kerman in 2016. The participants were selected by the consecutive sampling method and were assigned to intervention and control groups. In the intervention, the participants were informed by the nurse about changes in the patient’s condition during the first three days of admission to intensive care unit. During this period, the control received routine care. Data collection tool was the Spielberger anxiety inventory. Independent and paired t-test were used to compare the mean scores of anxiety using the SPSS software version 16. Results: There was no statistically significant difference in the mean scores of overt, covert and general anxiety between the two groups before the intervention (P>0.05). However, after the intervention in the experimental group, the mean scores of overt anxiety (45.51±7.26), covert anxiety (45.42±6.51) and general anxiety (90.93±12.72) decreased (P<0.05) compared to the mean scores of overt anxiety (49.22±9.42), covert anxiety (49.02±9.15) and general anxiety (98.24±17.67) in the control group. Conclusion: Providing planned information on changes in the condition of hospitalized patients with traumatic brain injury can reduce the anxiety of family members of these patients. Clinical trial registry: IRCT20180206038642N2
Assessing the impact of nutrition interventions on health and nutrition outcomes of community-dwelling adults: a systematic review

Background: Malnutrition is pervasive in hospitalized patients and older adults. Although evidence shows the benefits of nutrition interventions in hospitalized patients, less is known about the role these interventions play on outcomes in patients in the community. Objective: The objective of this systematic review is to evaluate the current evidence on nutrition interventions’ impact on health and nutrition outcomes among community-dwelling adults. Methods: This systematic review was performed using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Original studies of previously published research were identified by using a predefined search strategy. Articles identified through electronic and manual searches were compared against predefined study selection criteria. Results: Twenty articles were deemed eligible for inclusion. Most of the studies examined nutrition interventions through oral nutritional supplements, dietary advice, counseling, and home visits, and were conducted in subjects who either had or were at risk of malnutrition. Nutrition interventions were found to improve anthropometrics (body weight), nutritional and functional status, energy and protein intake, and muscle strength (handgrip strength). However, their impact was inconclusive for body composition, quality of life, readmissions, complications/morbidity, and mortality, mainly due to a limited number of studies. Conclusion: Nutrition interventions were found to improve health and nutrition outcomes among community-dwelling adults. Future research is needed to examine the pervasiveness of malnutrition in the community, to evaluate the impact that nutrition interventions have on improving health outcomes in this population, and to inform the design of novel nutrition-focused intervention programs for adults living in different community settings to improve outcomes.
Collision mortality of local and migrant birds at a large-scale wind-power development on Buffalo Ridge, Minnesota

In 1994 Xcel Energy initiated a wind-power development project in southwestern Minnesota that will eventually produce 425 megawatts (MW) of electricity. During our study the wind farm consisted of 3 phases of development totaling 354 turbines capable of generating 236 MW, depending on wind speed. We assessed effects of the wind farm on birds from 1996 to 1999, with 55 documented collision fatalities. Recovered carcasses included 42 passerines, 5 waterbirds, 3 ducks, 3 upland game birds, 1 raptor, and 1 shorebird. Most fatalities (71%) were likely migrants through the area, 20% were species that likely were breeding in the study area, and 9% were permanent residents. Wind farm-related mortality was estimated by extrapolating the number of carcasses found at a sample of the turbines and adjusting for scavenger removal and searcher efficiency rates. We estimated total annual mortality at 72 (90% CI=36-108) in the Phase 1 wind farm, 324 (90% CI=175-473) in the Phase 2 wind farm, and 613 (90% CI=132-1093) in the Phase 3 wind farm. The Phase 3 wind-farm estimate was based on 1 year of data and was largely influenced by a single mortality event involving 14 passerines at 2 adjacent turbines during 1 night. Radar data indicated that approximately 3.5 million birds migrate over the wind farm each year; however, the proportion of birds flying at heights susceptible to turbine collisions is not known. Wind-power development will likely contribute to cumulative collision mortality of birds in the United States.
Scanning training for rehabilitation of visual field loss due to stroke: Identifying and exploring training tools in use

Introduction Visual field loss affects one fifth of stroke survivors, limiting daily activities and reducing quality of life. Scanning training is a commonly used intervention, but there is variation in how this is delivered. This study aimed to identify the scanning training tools used in Scotland and describe their training parameters, delivery and suitability for use with stroke survivors. Method An email survey identified scanning training tools used in Scotland. Two expert panel meetings gained consensus on the motor, language and cognitive skills required to use each scanning training tool. Video capture techniques gathered objective measures of training parameters. Results Ten scanning training tools were identified. These tools used four delivery methods: paper-based, computer software, web-based and specialised equipment. They aimed to improve reading, perception or general visual skills. Fast, saccadic eye movements were most frequently targeted: two interventions also encouraged head movements. Session duration, frequency and therapist support varied considerably. The level of motor, language and cognitive skills required for each tool was determined. Conclusion Scanning training tools used in Scotland vary in delivery modality, functional abilities required for use and visual skills trained. This information will support clinical decision-making and inform future research on training effectiveness and feasibility.
Time to treatment of prostate cancer patients

Prostate cancer is one of the most common cancers in men. the incidence of prostate cancer increases systematically. the correlation between waiting time for oncological treatment and survival prognosis in prostate cancer is not clearly determined. the aim of the study was to estimate the waiting time from suspicion until prostate cancer diagnosis and treatment in Warmia and Mazury Voivodeship. ninety-six consecutive prostate cancer patients treated with radical radiotherapy between november 2016 and June 2017 in the Department of Radiation oncology of the Hospital of the Ministry of internal affairs with Warmia and Mazury oncology center in olsztyn were included in the analysis. a questionnaire prepared especially for this study, and individual interviews with patients were used in the study. the obtained data was supplemented with medical records and hospital databases. in the case of twenty-nine men, the PSa concentration was measured due to urinary disorders, and the median time from symptoms until the first PSa test in that group was 168 days. the median time from PSa concentration > 4 ng/ml to biopsy of prostate cancer and start of treatment for all patients was 62 and 156 days, respectively. Hormone therapy was administered the quickest. a positive correlation was observed between the waiting time from histopathological confirmation of prostate cancer until treatment, and the distance from one’s place of residence to the oncological center (p < 0.05).