Miracle-dz/UniFAR-FTUs huggingface dataset:
Customized Additive Manufacturing in Bone Scaffolds—The Gateway to Precise Bone Defect Treatment

In the advancing landscape of technology and novel material development, additive manufacturing (AM) is steadily making strides within the biomedical sector. Moving away from traditional, one-size-fits-all implant solutions, the advent of AM technology allows for patient-specific scaffolds that could improve integration and enhance wound healing. These scaffolds, meticulously designed with a myriad of geometries, mechanical properties, and biological responses, are made possible through the vast selection of materials and fabrication methods at our disposal. Recognizing the importance of precision in the treatment of bone defects, which display variability from macroscopic to microscopic scales in each case, a tailored treatment strategy is required. A patient-specific AM bone scaffold perfectly addresses this necessity. This review elucidates the pivotal role that customized AM bone scaffolds play in bone defect treatment, while offering comprehensive guidelines for their customization. This includes aspects such as bone defect imaging, material selection, topography design, and fabrication methodology. Additionally, we propose a cooperative model involving the patient, clinician, and engineer, thereby underscoring the interdisciplinary approach necessary for the effective design and clinical application of these customized AM bone scaffolds. This collaboration promises to usher in a new era of bioactive medical materials, responsive to individualized needs and capable of pushing boundaries in personalized medicine beyond those set by traditional medical materials.
Optimizing the Accuracy of Microcomb-Based Microwave Photonic Transversal Signal Processors

Microwave photonic (MWP) transversal signal processors offer a compelling solution for realizing versatile high-speed information processing by combining the advantages of reconfigurable electrical digital signal processing and high-bandwidth photonic processing. With the capability of generating a number of discrete wavelengths from micro-scale resonators, optical microcombs are powerful multi-wavelength sources for implementing MWP transversal signal processors with significantly reduced size, power consumption, and complexity. By using microcomb-based MWP transversal signal processors, a diverse range of signal processing functions have been demonstrated recently. In this article, we provide a detailed analysis for the processing inaccuracy that is induced by the imperfect response of experimental components. First, we investigate the errors arising from different sources including imperfections in the microcombs, the chirp of electro-optic modulators, chromatic dispersion of the dispersive module, shaping errors of the optical spectral shapers, and noise of the photodetector. Next, we provide a global picture quantifying the impact of different error sources on the overall system performance. Finally, we introduce feedback control to compensate the errors caused by experimental imperfections and achieve significantly improved accuracy. These results provide a guide for optimizing the accuracy of microcomb-based MWP transversal signal processors.
On the characteristics of the plankton at Kandla in the Gulf of Kutch during August 1958—July 1960

The study of plankton and hydrology is of fundamental importance in the marine biological research programmes and our present knowledge on these aspects, which still remains far from satisfactory, is owing to a few contributions (Bal et al 1946, Bal and Pradhan 1952 ; Chidambaram and Menon 1945 ; Ganapati and Sarma 1958; George 1953; Jacob and Menon 1947 ; Hornell and Nayudu 1923 ; Menon 1945 ; Prasad 1956 ; Ramamurthy 1953 and Subrahmanyan 1959). Practically no information is available from the Gulf of Kutch on the west coast of India.
Macrofloral remains from the Lower Cretaceous of the Leiva region (Colombia)

Lower Cretaceous plant fossils are described systematically from marine deposits near Villa de Leiva (Boyaca region, Colombia). Specimens originating from the same localities kept at the Florida Museum of Natural History (Gainesville) were included in the systematic description. The plant fossils belong to the Pteridophyta, the Cycadophyta, the Coniferophyta, and to taxa of uncertain affinity which, following previous authors, are referred to the angiosperms. Two new species of Coniferophyta are described, viz. Cupressinocladus hoedemaekeri sp. nov. and Brachyphyllum winklerprinsii sp. nov. Also, Thuites sutamarchensis Huertas is transferred to the genus Cupressinocladus. Fossil plants, Lower Cretaceous, Leiva Region, Colombia.
Nutrientes y renovación del agua en aiguamolls de l’Empordà. (NE de la península Ibérica). Uso potencial de agua residual para la inundación de zonas húmedas

The monitoring of the ecological water quality of 'Aiguamolls de l’Emporda' Natural Park was carried out between September 1996 to August 1997. The aim was to evaluate the impact of effluent from a nearby wastewater treatment plant, on the flooding of marshes in the Natural Park. In this paper we present physical and chemical data together nutrient concentrations and its changes in the lentic system of the 'Aiguamolls de l’Emporda'. The ultimate aim was to evaluate the effect of reclaimed wastewater on the salt marsh system. Seasonal variation in nutrients concentrations and their relationship to turnover and source of water were analysed. Significant variation in the N/P ratio was related to water turnover. Confined systems presented lower values for this ratio. Taking into account the nutrient concentrations of the reclaimed water, which is rich in nitrogen, it is recommended flooding applied in zones with high water turnover and higher N/P ratios
Grid Dielectric Resonator Antenna Planar Arrays With Simple Feeding Network

A novel grid dielectric resonator antenna (DRA) planar array is proposed in this communication. In this design, the concept of traditional microstrip grid antenna array is applied to DRA for the first time, which greatly simplifies the complexity of the feeding network. It is noteworthy that the grid DRA array was constructed in a DR structure with a simple power divider circuit. First, a nine-element grid linearly polarized (LP) DRA planar array with simple feeding network is proposed to realize a fractional bandwidth (FBW) of 10% and a peak gain of 13.7 dBi. Next, a grid circularly polarized (CP) DRA array with four proposed LP DRA elements is designed.
Role of SARS‑CoV‑2 nucleocapsid protein in affecting immune cells and insights on its molecular mechanisms

The present study aimed to explore the immune regulatory function of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nucleocapsid (N) protein and related mechanisms. In a series of protein activity experiments, SARS-CoV-2 N protein promoted proliferation of three immune cell lines: mouse Raw264.7, human Jurkat and human Raji in a dose-dependent manner. A total of 10 µg/ml N protein could significantly change cell cycle progression of the aforementioned three immune cell lines and could promote quick entry of Raw264.7 cells into G2/M phase from S phase to achieve rapid growth. Additionally, the N protein could also stimulate Raw264.7 cells to secrete a number of proinflammatory factors such as TNF-α, IL-6 and IL-10. RNA sequencing analysis indicated that the N protein changed the expression of certain genes involved in immune-related functions and four important signaling pathways, including JAK-STAT, TNF, NF-κB and MAPK signaling pathways, which suggested that the N protein may not only regulate the expression of genes involved in the process of resisting viral infection in macrophages of the immune system, but also change cellular signal processing.
Exploring the Potential Association Between Self-Reported Psychological Stress and Cerebrospinal Fluid Biomarkers of Alzheimer’s Disease in Midlife: A Cross-Sectional Study

Psychological stress is associated with dementia risk. However, the underlying mechanisms are unclear. This cross-sectional study examined the association between self-reported psychological stress and cerebrospinal fluid (CSF) biomarkers of Alzheimer’s disease and neurodegeneration in 73 cognitively unimpaired middle-aged adults from the Healthy Brain Project (mean age = 58±7 years). Linear regression analyses did not reveal any significant associations of psychological stress with CSF amyloid-β42, phosphorylated tau-181, total tau, or neurofilament light chain. Cohen’s f2 effect sizes were small in magnitude (f2≤0.08). Further research is needed to replicate our findings, particularly given that the sample reported on average low levels of stress.
IDENTIFYING MOTIVATORS OF ECOTOURISM DESTINATION COMPETITIVENESS: THE EXAMINATION ON SOFT INFRASTRUCTURE CONSTRUCTS AND MODERATING IMPACT OF MOBILE TECHNOLOGY

The development of ecotourism in Malaysia is crucial in the current digitalized world, as nature enthusiasts seek authentic travel experiences to reconnect with the environment. This study focuses on investigating the link between government tourism policy, health services, safety and security, destination competitiveness, and the moderating effect of mobile technology. The study was conducted on 170 domestic tourists who visited various national parks in Sarawak, Malaysia. The data collected has undergone preliminary analyses using SPSS 26.0 while the proposed study model was evaluated using WarpPLS 8.0, which allowed for path modelling and bootstrapping to obtain the estimates of standard error and p-values. The results indicated a significant direct relationship between health services and destination competitiveness. Mobile technology was found to moderate the relationship between government tourism policy, safety and security, and destination competitiveness. However, due to the COVID-19 pandemic, the study was limited to domestic tourists, and the implications of these findings are discussed.
Past endemic malaria and adaptive responses in the fens and marshlands of eastern England

Changes in climate have increased concerns over the return of temperate malaria to the United Kingdom. Hence, studies of ancient disease are becoming more relevant for future health predictions in areas which are under threat of disease re-emergence. Conditions were likely ideal for Plasmodium vivax malaria from at least the Roman period, and recent research on Anglo-Saxon Fen populations has suggested an indigenous malarial presence. The primary aim of this project was to investigate the presence of English malaria in archaeological Fen cemetery populations from the Roman, Anglo-Saxon, and later medieval periods (c. AD 40-1600), using biomolecular analyses of human bone, and palaeopathological analyses via extant published data. A further aim was to investigate Masters’ (1987) hypothesis concerning preferential survival of non-collagenous proteins (NCPs) within archaeological bone. Indirect evidence for malaria was sought by reassessing archaeological reports for osteological evidence of the genetic anaemia β thalassaemia at 13 cemetery sites (five Roman, seven Anglo-Saxon, one late medieval) closely associated with the Fens and marshlands of Lincolnshire and Cambridgeshire. A palaeodemographic comparison of 30 Fen (five Roman, 21 Anglo-Saxon, four late medieval) and 31 non-Fen (nine Roman, 18 Anglo-Saxon, four late medieval) cemetery populations was also undertaken to assess any impact of vivax malaria on mortality. Osteological evidence does not support the presence of past thalassaemia, with palaeodemographic analysis suggesting an acquired, rather than genetic immunity in the Fens. Possible evidence emerged for ‘healthy adaptation’ to the increased stresses of Fenland life, and one population provided tentative evidence of intrauterine growth restriction, a condition strongly linked to endemic P. vivax. Direct evidence was sought by attempting to extract and test anti-malarial antibodies from human bone samples from 13 Fen-associated cemetery sites (five Roman, seven Anglo-Saxon, one late medieval), encompassing 24 individuals. Bone preservation was assessed in over 200 samples to provide a baseline for sample selection for biomolecular analysis. Analysis of bone samples proved unsupportive of Masters’ (1987) hypothesis. However, a range of endogenous proteins and a possible pathogenic disease marker were revealed, as was a correlation between bone preservation and NCP content. Evaluation of extraction protocols failed to yield antibodies which, if present, were consistently masked by collagen. Consequently, a novel antibody extraction technique has been developed. If successful, this could lead to a replicable technique of ancient, reactive antibody isolation, which would offer an invaluable new tool in biomolecular palaeopathology.
Antimicrobial Activities of Propolis Samples Collected From Different Provinces of Turkey

The propolis, which is a natural product that is collected by honey bees from the plants, especially flowers and buds, by mixing it with wax and resin, is used in the hive for many purposes. Apart from the use by the bees in the hive, propolis is a versatile compound that is used in medicine, cosmetics, food industry and apitherapy and which contains a wide variety of chemical substances having antibacterial and antioxidant effects. It was determined that the antimicrobial effects of propolis samples were higher against the Gram-positive bacteria species included in the study when compared to the Gram-negative bacteria and yeasts. The majority of the samples were found to be highly sensitive (16 mm and larger), while some were found to be moderately sensitive (11-15 mm). Among all strains of bacteria; it was demonstrated that the propolis sample obtained from Cankiri (Yaprakli) region performed the highest activity against Staphylococcus aureus while the lowest activity was performed by the propolis sample obtained from Balıkesir region against E. coli . In addition, it was determined that the propolis sample obtained from Eskişehir region had no antifungal effect against Candida parapsilosis yeast strain. It was specified that the antimicrobial activity demonstrated by all microorganisms against the propolis samples was less effective when compared to the control compounds, except for Candida krusei .
Spinning Through History: Evolution of the Concept of Vestibular Migraine

Vestibular migraine represents a growing public health problem, imposing enormous societal burdens in the form of patient suffering, loss of productivity, and direct healthcare costs. This raises the question of how we developed our ideas about vestibular migraine and how these ideas shape how we treat it. This review walks through the history of how our conceptualization of migraine and vestibular symptoms evolved, starting with clinical observations in ancient times, inclusion under the umbrella of Meniere’s disease, and then separation from Meniere’s disease with its own identity. Tradition, clinical observations, and diagnostic criteria developed by professional societies have played prominent roles in building our current concept of vestibular migraine. A review of the ideas that have shaped our current conception of vestibular migraine may help us to see which ones have stood the test of time and which ones should continue to evolve. As in other disciplines, we study history in medicine to be inspired, warned, and sometimes, to be freed.
Prevalence of Postoperative Hypothermia in the Post-anesthesia Care Unit

Background Unwanted postoperative hypothermia is an unpleasant event that can cause various complications. Objectives As this serious complication and its provoking causes have not been investigated sufficiently, this study was designed and conducted to determine the prevalence of hypothermia and its associated factors in the post-anesthesia care unit after elective surgery. Methods Four hundred patients undergoing elective surgeries were enrolled in the present cross-sectional research after termination of surgery and at the time of arrival at the post-anesthesia care unit of Poursina Public University Hospital. The tympanic membrane temperature was measured and recorded at the time of arrival at the post-anesthesia care unit and every 30 minutes after arrival. The required data were collected in a researcher-made checklist and analyzed after entering the SPSS software version 25. Results Considering the 5% error, it can be said that the prevalence of hypothermia in patients undergoing elective surgery ranges from 20 to 28% at the time of arrival at the post-anesthesia care unit and 18.5 to 26% 30 minutes after arrival. Conclusions More than a quarter of patients experienced hypothermia following elective surgery. Therefore, appropriate treatment and control measures are necessary to manage this complication, particularly in patients with predisposing risk factors and comorbidities.
Acacia mangium plantations in PT Musi Hutan Persada, South Sumatera, Indonesia

PT Musi Hutan Persada, a forestry company growing wood for pulp in South Sumatra manages about 200 000 ha of forest plantations, 90% of which consists of Acacia mangium. Most of the plantations are in an area with high rainfall and on red-yellow podzolic soil with inherently poor fertility and low pH. Inter-rotation site productivity and management have been identified by the company as one of the crucial issues for sustaining the long-term productivity of its plantations. This paper describes the study plan for inter-rotation site productivity and management of A. mangium plantations in PT Musi Hutan Persada. The experiment tests the on-site effect of different treatments of organic matter or aboveground biomass management. Information from earlier work indicates that most A. mangium biomass and three major nutrients (N, P and K) is in the wood, and harvesting will remove around 200 kg N, 45 kg P and 240 kg K per hectare. Litter production of an 8-year old stand was about 13 t ha -1 and about 70% of its mass will be lost in one year.
More than trichomes and acylsugars: the role of jasmonic acid as mediator of aphid resistance in tomato

ABSTRACT This study investigates the impact of priming on the resistance of tomato plants to the potato aphid Macrosiphum euphorbiae, focusing on the role of glandular trichomes. Glandular trichomes are specific hairs that provide protection to tomato plants against herbivorous insects. The experimental priming conducted in this study revealed that prior infestation by Spodoptera littoralis caterpillars increased the plant's resistance against M. euphorbiae, pointing at the jasmonic acid (JA) signaling pathway in regulating this plant-aphid interaction. Glandular trichomes type IV were effective against aphids regardless of the previous infestation. Using JA-deficient tomato (spr2), we observed that M. euphorbiae multiplication increased, while the number of aphids on salicylic -deficient NahG plants was lower than in the wildtype Moneymaker. These findings emphasize the crucial role of the JA signaling pathway in tomato plant resistance to aphids and the importance of glandular trichomes to enhance plant defences against pests.
Risk Factor Analysis of Anxiety Disorder in Third Trimester Pregnant Women

Introduction: Pregnancy is a natural thing for productive women. Anxiety that occurs in pregnancy is an emotional response related to the concern felt by the mother for the well-being of herself and her fetus during pregnancy, childbirth and the role of being a mother later. The purpose of this study was to determine the relationship between age, level of education, occupation, economy, parity, environmental status, and religious spiritual activities on anxiety disorders in third trimester pregnant women in Somba Opu District, Gowa Regency. Methods: The instrument in this study used a questionnaire. The sample used in this study consisted of 136 third trimester pregnant women in the work area of ​​Syekh Yusuf Hospital and Sungguminasa Health Center. Data was processed and analyzed as needed and data analysis using Chi Square test p<0.05 Results: The study showed that there was a significant relationship between age, education level, occupation, economic factors, parity, and religious spiritual activities with anxiety disorder levels in third trimester pregnant women and this study did not show that there was a significant relationship between living environment status. with the level of anxiety disorder in third trimester pregnant women (0.514) Conclusion: There is a relationship between age, education level, occupation, economic factors, parity, and religious spiritual activities with anxiety disorder levels in third trimester pregnant women, and there is no relationship between living environment status and anxiety disorder levels in third trimester pregnant women.
Retrospective analysis of the impact of dose delay and reduction on outcomes of colorectal cancer patients treated with FOLFIRI‑based treatment

Objectives To determine the relationship between chemotherapy dose delay/reduction with progression-free survival (PFS) and overall survival (OS) in colorectal cancer patients treated with FOLFIRI based first-line chemotherapy in real-world retrospectively study. Methods We identified 144 eligible patients with advanced CRC who received FOLFIRI as first-line based treatment. The study protocol was submitted to the institutional review board and was exempted. Dose delay was defined as an average delay of more than 3 days (>3 days vs. ≤3 days) from the intended date. Dose reduction (actual dose/standard dose * 100%) ≤85% was considered as chemotherapy reduction in the chemotherapy dose relative to the standard (mg/m2) regimen for all cycles. Relative dose intensity (RDI) ≤80% was described as chemotherapy reduction. OS and PFS were measured using Kaplan–Meier and Cox proportional hazard models. Results There were 114 patients with chemotherapy dose delay (dose delay >3 days). PFS of patients without dose delay had better survival than patients with dose delay (p = 0.002). There were 28.47% patients treated with dose reduction of 5-Fu. PFS and OS were better in patients without 5-Fu dose reduction than in patients with 5-Fu dose reduction with p values of 0.024 and <0.001, respectively. Patients with high 5-FU RDI had better PFS than patients with low 5-FU RDI (p < 0.001). While, there was no statistical difference in OS between the two groups. Then we stratified the analysis by age. In <65 years cohort, both PFS and OS were better in patients with high 5-Fu RDI than in those with low 5-Fu RDI (p < 0.001, p = 0.005, respectively). But, in ≥65 years cohort, OS were better in patients with low 5-Fu RDI than in those with high 5-Fu RDI (p = 0.025). Moreover, both dose reduction and RDI of irinotecan had no statistically significant difference in both PFS and OS. Conclusion In the advanced colorectal cancer patients who received FOLFIRI based treatment as first-line regimen, chemotherapy dose delay and reduction dose of 5-Fu were associated with worse survival, especially among patients younger than 65 years.