Miracle-dz/UniFAR-FTUs huggingface dataset:
Randomized trial of cytoreduction and hyperthermic intraperitoneal chemotherapy vs . systemic chemotherapy and palliative surgery in patientswith peritoneal carcinomatosis of colorectal origin

Randomized trial of cytoreduction and hyperthermic intraperitoneal chemotherapy vs. systemic chemotherapy and palliative surgery in patientswith peritoneal carcinomatosis of colorectal origin. VJVerwaal,S van Ruth,E de Bree,H vanTinteren,HBoot, GW van Slooten,FANZoetmulder. Depts. of Surgery, Medical Statistics and Gastroenterology, Netherlands Cancer Institute/Antoni van Leeuwenhoek Hospital, Amsterdam,The Netherlands.
Twenty-Four Hour Recordings of Colonic Motility in Patients with Diverticular Disease: Evidence for Abnormal Motility and Propulsive Activity

INTRODUCTION Diverticular disease of the colon is one of the most common pathologic entities in western countries. Although altered motility of the large bowel is commonly believed to be one of the major pathophysiologic mechanisms, no convincing evidence has been reported yet. In fact, only a few conflicting studies concerning distal colonic motility (with no information on forceful propulsive activity) are available in the literature. PURPOSE The purpose of the present study was to investigate basal and stimulated (postprandial) colonic motility from the transverse (not affected), descending, and sigmoid colon in patients with diverticular disease, together with detection of high-amplitude propagated contractions (mass movements). Motility data from patients were compared with those obtained in healthy control subjects. METHODS Ten patients and 16 control subjects of both sexes were recruited for the study. In all subjects, colonic motility was recorded for a 24-hour period by a colonoscopically positioned manometric catheter. Two 1000-kcal mixed meals were served during the study. RESULTS Compared with control subjects, patients with diverticular disease displayed significantly increased amounts of motility in the affected segments; the response to a physiologic stimulus (meal) was also abnormal in the patients’ group. Diverticular disease patients also had a significant increase of forceful propulsive activity compared with control subjects (average = 10.3 ± 2.7/subject/day high-amplitude propagated contractions for patients and 5.5 ± 0.8/subject/day for control subjects;P = 0.051); interestingly, about 20 percent of such activity was abnormal, being propagated in a retrograde fashion. CONCLUSIONS We concluded that patients with diverticular disease of the colon have abnormal motor and propulsive activities of the large bowel, which are confined to the affected segments.
Epididymal morphophysiology of adult collared peccaries

A functional understanding of the epididymis makes it possible to increase a species’ fertility, since it facilitates the preservation of gametes for use in assisted reproduction techniques. This study analyzed the histological features of the different regions of the epididymis of the Pecari tajacu and the associated pathologies found in the spermatozoa present in this organ. After an orchiectomy surgery to remove the testicles and epididymis obtained from eight adult animals bred in captivity, fixation and histological processing of samples were carried out. The presence of pseudostratified columnar epithelium with stereocilia was observed in all regions of the epididymis (caput, corpus and caudal). Similarities were noted between the average height of the corpus and caudal epithelium, which differed from that found at the caput (1proximal: region associated with the efferent ducts; 2distal: region associated with corpus epididymis). It was also observed that the proximal caput presents a smaller average of the tubules diameter compared to other portions of the epididymis. Regarding pathologies of the spermatozoa, thirteen different types of morphological modifications were observed. Underdeveloped spermatozoa and detached heads were most frequently encountered along the epididymis of the collared peccaries. This study is a pioneer in the area and its data will serve as a basis for comparative research on the reproductive biology of artiodactyls, thus contributing to their conservation and reproduction.
Tarsal coalition

Tarsal coalition is a congenital bridging between the tarsal bones of the foot caused by a failure of differentiation and segmentation of primitive mesenchyme. It is the most common cause of a rigid flatfoot in children, adolescents, and young adults. As new imaging modalities have been developed, our diagnosis of this condition has increased and treatment has progressed from conservative measures to more aggressive surgical treatments. This review article summarizes the etiology, epidemiology, clinical presentation, radiographic features, and current ideas on treatment, as well as highlighting the prognosis and pitfalls of surgical treatment.
Prevalence of Various Complications in Type II Diabetes Mellitus in Rural Medical College of Central India-A study

1 Assistant Professor Deptt.of Medicine, Bundelkhand Medical College, Sagar, MP 470001. 2 Assistant Professor Deptt.of Obs / Gyn, Bundelkhand Medical College, Sagar MP. 3 Professor, Deptt. of Medicine, Mahatma Gandhi Medical College, Bhopal, MP. Corresponding Author Dr . Jyoti Tiwari Sagar Diagnostic Centre, Near City Kotwali, Chakraghat Sagar, MP 470002 Email: drtiwari@rediffmail.com, drtiwari2011@gmail.com Phone number 09827760212 Abstract – Aim of studyTo detect prevalence of various complications of type 2 diabetes mellitus in a rural tertiary government health care hospital of central india. Materials and methods –Diabetes mellitus is now an increasing health concern for both urban as well as rural populations of India. In this study we evaluated the prevalence of various microvascular and macro vascular complications in patients of OPD/IPD of Bundelkhand Medical College, Sagar MP. The study conducted from Apr 2014Sept 2014.Total 1970 patients were included in the study by random sampling. Detailed history, clinical examinations, anthropometric measurements and biochemical examinations were done. American Diabetes Association criteria (ADA) were used for diagnosis of diabetes mellitus and standard definitions were used to define the diabetic patients. Data were analysed by SPSS software version 12. ResultsAmong the 1970 patients studied 1025 (52%), patients were male & 945(48%), patients were female. Out of which 270 patients were diabetic (13.7%). The associated diabetic comlications was as followsNeuropathy (n=70, 25.9%), Nephropathy (n=43, 15,5%), Coronary artery disease CAD (n=42%, 15.5), Retinopathy (n=22 ,8.1%), Peripheral vascular disease (n=15, 5.5%), Cerebrovascular accidents (n=10, 3.7%). Along with the complications we have also observed a rising trend in the diabetic complications associated with increased duration of illness as well as persistently high blood sugar levels. ConclusionsAs the complications of diabetes are higher with higher blood sugars levels and long duration of diabetes hence the disease needs to be diagnosed and treated as early as possible by doing routine screening for diabetes & diabetes awareness programme should be there for early diagnosis of the disease and treatment to prevent complications.
BREAKOUT FOR SESSION IV Local Antibiotic Delivery Systems Where Are We and Where Are We Going ?

The use of local antibiotic delivery systems has become an accepted treatment method that continues to evolve for a variety of reasons. There has been an explosion of new technologies that are designed to facilitate the delivery of local antibiotics in new and creative ways. The primary reason for using these local antibiotic delivery vehicles is the ability to achieve very high local concentrations of antibiotics without associated systemic toxicity. In the typical infected wound environment, which frequently has zones of avascularity, the ability to achieve high levels of antibiotics in these otherwise inaccessible areas is highly desirable. Additional reasons for use of these delivery vehicles include the desire to treat remaining planktonic organisms and sessile organisms in biofilms more effectively with high concentrations of antibiotics. Because bone regeneration often is required as a part of the treatment plan, a recent trend has been simultaneously to provide a framework of osteoinductive and osteoconductive materials along with antibiotic delivery. Despite the rapid acceptance of these antibiotic delivery vehicles, there are many unanswered questions related to their use, particularly when viewed within the environment of biofilms that were discussed in this symposium. Some of the questions discussed are outlined below. How high do we need to get the concentration of these antibiotics and what is the desirable duration of these high levels? What are the adverse clinical consequences of extremely high levels of antibiotics, particularly at the local level and specifically with regard to the process of bone regeneration? Are new and creative dosing regimens required with multiple combinations of antibiotics to address unique patterns of resistance associated with biofilms? Can the traditional methods of assessing antimicrobial susceptibility of pathogenic organisms be extrapolated to the efficacy obtained with these high concentrations of antibiotics? What types of models are required to study the efficacy of antibiotics on sessile organisms contained within biofilms? Are there nonantimicrobial options to consider that can augment the efficacy of current antimicrobials? And finally, how do clinical investigators actively use these new concepts and rapidly changing technologies when the burdens of federal regulation seem to prevent their use?
Arg399Gln XRCC1 Polymorphism and Risk of Squamous Cell Carcinoma of the Head and Neck in Jordanian Patients

Background and Objective: X-ray repair cross-complementing group1 (XRCC1) is a key protein in base excision repair and closely associated with the coordination of the base excision repair pathway. Many studies have focused on XRCC1 SNPs and have shown an associated between these SNPs and the risk of several types of cancers, including head and neck cancer. There are many single nucleotide polymorphisms XRCC1 gene (SNPs) and the most common SNP that result in amino acid substitutions is exon 10 (Arg399Gln). This study aimed to investigate the association between Arg399Gln SNP and the risk of squamous cell carcinoma of the head and neck. Materials and Methods: Ninety nine patients with squamous cell carcinomas of the head and neck and 89 healthy adult controls were enrolled in this study. The Arg399Gln in XRCC1 allele was genotyped using polymerase chain reaction-restriction fragment length polymorphism method. Results: In the single-locus analyses, Arg399Gln SNP showed a significant association with head and neck cancer risk (p value = 0.016 and odd ratio of 1.8). On the genotype level, we applied three analysis models, namely co-dominant, dominant, and recessive genotypes. Arg/Arg homozygous major genotype was significantly (p value <0.05) associated with head and neck squamous cell carcinoma incidence with odd ratio of 2.23 and 2.24 for the co-dominant and recessive models, respectively. Conclusion: The findings indicated that Arg399Gln allele was associated with squamous cell carcinoma of the head and neck among Jordanian patients. This allele might be used as a genetic biomarker of squamous cell carcinoma of the head and neck.
The Lobster and Shrimp Fisheries in Hawaii

A description of the lobster and deepwater shrimp fisheries in Hawaii, addressing harvest levels, biology, and research, is presented. Bothfisheries are trap fisheries. The lobsterfishery is a limited entry fishery with 1991 landings of 200 metric tons. The shrimp fishery is unregulated, with very sporadic effort, and annual landings below 200 metric tons. 19832
Is Hair Transplantation Indicated in Frontal Fibrosing Alopecia? The Results of Test Grafting in Three Patients

In two separate recent reports of Asian patients with skin types III to V with vascular blebs treated using a long-pulsed 1,064-nm Nd:YAG laser, the authors found that a majority of patients required multiple treatments to achieve clinical improvement in appearance of the lesions. In the larger of the two studies, the authors treated 21 patients and found that only 11 (52.3%) achieved more than 75% improvement in the clinical appearance of lesions. Furthermore, most blebs required three or fewer treatments, with only seven (33.3%) requiring one treatment to achieve more than 75% clearance. This is in comparison to our experience of more than 75% improvement in clinical appearance in 100% of treated blebs after one treatment session.
Ovarian reserve after salpingectomy : a systematic review and meta-analysis Running headline : Ovarian reserve and salpingectomy

Introduction: Although there has been a growing concern over the possible damaging effect of salpingectomy on ovarian reserve, this issue remains uncertain. The purpose of this metaanalysis was to test the hypothesis that salpingectomy may compromise ovarian reserve. Material and methods: A detailed search was conducted using MEDLINE, Embase, Dynamed Plus, ScienceDirect, TRIP database and the Cochrane Library from January 2000 to November 2016. All cohort, cross-sectional and randomized controlled studies investigating changes in circulating anti-Müllerian hormone (AMH) after salpingectomy were considered. Thirty-seven studies were identified, of which eight were eligible. Data were extracted and entered into RevMan software for calculation of the weighted mean difference (WMD) and 95% confidence interval (CI). Two groups of studies were analyzed separately including group 1 (six studies, n=464) comparing data before and after salpingectomy and group 2 (two studies) comparing data in women who have undergone salpingectomy (n=169) vs. healthy controls (n=154). Results: Pooled results of group 1 studies showed no statistically significant change in serum AMH concentration after salpingectomy (WMD, -0.10ng/ml; 95% CI; -0.19 – 0.00, I 2 =0%). Similarly, meta-analysis of group 2 showed no statistically significant difference in serum AMH concentration between salpingectomy group and controls (WMD, -0.11ng/ml; 95% CI; 0.37 – 0.14, I 2 =77%). Subgroup analyses based on laterality of surgery, type of AMH kit and participants’ age (<40) still showed no statistically significant changes in circulating AMH. Conclusion: Salpingectomy does not seem to compromise ovarian reserve in the short-term. However, the long-term effect of salpingectomy on ovarian reserve remains uncertain.
Prevalence and distribution of HHV-8 in different subpopulations, with and without HIV infection, in Spain

Methods: A total of 1699 serum samples from blood donors (613), children under the age of 12 years (100), injecting drug users (IDU) (382), heterosexuals attending a sexually transmitted disease (STD) clinic (273) and homosexual men attending a STD clinic or a HIV-based hospital unit (331) were analysed for anti-HHV-8 antibodies. The presence of antibodies against HHV-8 was tested with an indirect immuno ̄uorescence assay (IFA). A subsample of HHV-8-positive samples was also tested for antibody titre against HHV-8.
What's Up with the Phillips Curve?

ABSTRACT:The business cycle is alive and well, and real variables respond to it more or less as they always did. Witness the Great Recession. Inflation, in contrast, has gone quiescent. This paper studies the sources of this disconnect using vector autoregressions and an estimated dynamic stochastic general equilibrium model. It finds that the disconnect is due primarily to the muted reaction of inflation to cost pressures, regardless of how they are measured—a flat aggregate supply curve. A shift in policy toward more forceful inflation stabilization also appears to have played some role by reducing the impact of demand shocks on the real economy. The evidence rules out stories centered around changes in the structure of the labor market or in how we should measure its tightness.
Restraining Bolts for Reinforcement Learning Agents

In this work we have investigated the concept of “restraining bolt”, inspired by Science Fiction. We have two distinct sets of features extracted from the world, one by the agent and one by the authority imposing some restraining specifications on the behaviour of the agent (the “restraining bolt”). The two sets of features and, hence the model of the world attainable from them, are apparently unrelated since of interest to independent parties. However they both account for (aspects of) the same world. We have considered the case in which the agent is a reinforcement learning agent on a set of low-level (subsymbolic) features, while the restraining bolt is specified logically using linear time logic on finite traces f/f over a set of high-level symbolic features. We show formally, and illustrate with examples, that, under general circumstances, the agent can learn while shaping its goals to suitably conform (as much as possible) to the restraining bolt specifications.1
Effects on Smooth Muscle Cell Migration and Proliferation

a single growth factor. We tested this hypothesis using amiloride and ethyl isopropyl amiloride (EIPA), which are inhibitors of the Na+-H+ exchanger, whose activity is required in many cells for proliferation and migration. In the rat carotid injury model, EIPA (100 ,ug/h for 15 days) significantly decreased intimal area and the ratio of intimal to medial area, whereas amiloride (25 jag/h) showed an inhibitory trend that was similar to that observed for captopril (80 mg/kg per day) and heparin (25 U/h). EIPA and amiloride inhibited rat vascular smooth muscle cell DNA synthesis, with IC5* values of 8.8 and 82.2 ,uM, respectively. Using platelet-derived growth factor as a chemoattractant, EIPA caused a concentrationdependent inhibition of migration (IC50, =60 pM). Because amiloride and EIPA have nonspecific effects on cellular function (especially inhibition of tyrosine kinases), we sought to characterize the specific role of the Na+-H+ exchanger in vascular smooth muscle cell proliferation and migration. We generated a Na+-H+ exchanger-deficient mutant cell line [RNHE(-)]. Studies with these cells suggested that the inhibitory effects of EIPA and amiloride were mediated only in part via Na+-H+ exchange because (1) RNHE(-) cells grew well at pH 6.8 to 7.5 in bicarbonate-containing medium, and (2) there was no difference in migration in response to platelet-derived growth factor in the RNHE(-) cells. In summary, these data indicate that amiloride and EIPA inhibit neointimal formation in the rat carotid after injury. However, the mechanism of inhibition is likely to involve cellular events other than Na+-H+ exchange, such as an effect on tyrosine kinases. (Circulation Research 1993;73:269-275)
Variability and Nonstationarity in Brain Computer Interfaces

A well-known problem in Brain Computer Interfacing (BCI) research is the large degree of variability in the acquired data. Every user has different brain signals, and also the performance of a user varies widely between sessions, within a session, between online and ofﬂine settings, and even from epoch to epoch. This variation can be caused by many factors such as psychological factors (e.g., fatigue, mood), physiological factors, change of task involvement (ofﬂine versus online task), learning, or measurement artifacts and noise. For maintaining good BCI performance, a BCI must be able to adapt to these changes. In our research we attempt to characterize these variability types in a BCI context. Therefore, we have conducted an EEG imagined movement experiment with 8 participants taking part in two sessions. Participants received two types of feedback, namely continuous during movement imagination, or once immediately after movement imagination. The performance of the BCI and some simple bias and gain adaptation methods for improving the feedback were analyzed.
Demography of Publications in South Asian Orthodontic Journals

Objective: To explore the demographic features of the articles published in South Asian orthodontic journals in the last 6 years. Materials and Methods: All the orthodontic journals published from or representing South Asian countries from 2011 to 2016 were analyzed for the number of issues published, number of articles, number of authors, country affiliation of principal author, and international collaboration in authorship. Further, article type was classified and number of citations was noted. Descriptive statistics was used to characterize the various features of the published articles. Results: A total of 825 articles were found in five orthodontic journals published from or representing South Asian region with the number authors per article ranging up to 10. International collaboration in authorship varied from 0.98% to 12.75% of articles among those journals. For all journals, principal authors of most of the articles originated from the country of publishing journal. Cross-sectional study overnumbered other types of researches. However, systematic reviews and meta-analysis which are considered as the highest form of evidence were very scant in these journals. Conclusions: International collaboration in authorship and foreign principal investigator was found minimum. Greater percentage of publications were cross-sectional studies with few randomized controlled trials and systematic reviews/meta-analysis in the last 6 years.