Miracle-dz/UniFAR-FTUs huggingface dataset:
Département d ' oncologie et Service d ' oncologie médicale La cessation de la chimiothérapie pour le traitement de l ' adénocarcinome pancréatique avancé : recherche de facteurs prédictifs

Pwpose We evaluated the attitude in using chemotherapy near the end of life in advanced pancreatic adenocarcinoma (PAC). Clinical and laboratmy parameters recorded at last chemotherapy administration were analyzed, in order to identify risk factors for imminent death. Methods Retrospective analysis of patients who undetwent at least one line of palliative chemotherapy was made. Data conceming chemotherapy (regimens, lines, and date of last administration) were collected. Clinical and laboratory factors recorded at last chemotherapy administration were: performance status, presence of ascites, hemoglobin, white blood cell (WBC), platelets, total bilirnbin, albumin, LDH, C-reactive protein (C-rp), and Ca 19.9. Results We analyzed 231 patients: males/females, 53/47 %; metastatic/locally advanced disease, 80/20 %; and median age, 66 years (range 32-85). All patients died due to disease progression. Median overall survival was 6.1 months (95 % CI 5.1-7 .2). At the last chemotherapy delivery, pe1fonnance status was 0-1in37 % and 2 in 63 %. Fifty-nine percent of patients received one chemotherapy line, while 32, 8, and This study was presented at ECCO ESMO 2011, Stockholm, poster presentation (abstr 6589). M. Frigeri Centre Pluridisciplinaire d'Oncologie, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland S. De Dosso ; K. Feuerlein; H. Neuenschwander: P. Saletti (1:8l) Oncology Institute of Southern Switzerland, Bellinzona, Switzerland e-mail: piercarlo.saletti@eoc.ch O. Castillo-Fernandez Instituto Oncologico Nacional, Panama City, Panama Published online: 01 June 2012 1 % had second-, third-, and fourth line, respectively. The interval between last chemotherapy administration and death was <4 weeks in 24 %, <:4-12 in 47 %, and >12 in 29 %. Median survival from last chemotherapy to death was 7.5 weeks (95 % CI 6.7-8.4). In a univariate analysis, ascites, elevated WBC, bilirnbin, LDH, C-rp and Ca 19.9, and reduced albumin were found to predict shorter survival; however, none of them remained significant in a multivariate analysis. Conclusions A significant proportion of patients with advanced PAC received chemotherapy within the last month of life. The clinical and laboratory parameters recorded at last chemotherapy delivery did not predict shorter survival.
POR_A_258632 67..76

Center for Sleep Medicine, Mayo Clinic, Phoenix, Arizona, USA Introduction: There are many options available to patients who are placed on constant positive airway pressure (CPAP) for obstructive sleep apnea. Despite the success of CPAP in correcting apnea, a significant number of patients have difficulty with the therapy. A large number of those patients who have difficulty stop therapy and are often labeled as “CPAP Failure”. Non-sleep specialists may view CPAP therapy as a singular course of treatment, but there are many ways CPAP may be ordered for a patient. Each patient experiences a unique set of options that constitute a unique order set. Methods: In order to demonstrate the magnitude of the possible options, estimates of the number of unique order sets were calculated. The author chose individual order options and the number of selections possible within each option. The calculated sets included a “Generous, Limited and Minimal” number of selections for each option. Calculations were done separately for standard CPAP and for auto-adjusting CPAP. Additional calculations were performed using the number of commercially available masks in the United States. Results: The maximum number of unique order sets was seen using a standard CPAP combined with commercially available masks: 49,152 unique order sets. The fewest number of unique order sets were seen with the auto-adjusting CPAP and the “Minimal” selections: 288 unique order sets. Discussion: There are a large number of unique CPAP orders that a patient may experience. CPAP treatment is not a singular or simple therapy. When evaluating obstructive sleep apnea patients with histories of CPAP failure or prior difficulty with CPAP, paying close attention to the patient’s treatment experiences may help explain a significant number of those patients’ CPAP therapy problems.
Relationships between Racket Arm Joint Moments and Racket Head Speed during the Badminton Jump Smash Performed by Elite Male Malaysian Players

Three-dimensional position data of nineteen elite male Malaysian badminton players performing a series of maximal jump smashes were collected using a motion capture system. A ‘resultant moments’ inverse dynamics analysis was performed on the racket arm joints (shoulder, elbow and wrist). Relationships between racket head speed and peak joint moments were quantified using correlational analyses, inclusive of a Benjamini–Hochberg correction for multiple-hypothesis testing. The racket head centre speed at racket–shuttlecock contact was, on average, 61.2 m/s with a peak of 68.5 m/s which equated to average shuttlecock speeds of 95.2 m/s with a peak of 105.0 m/s. The correlational analysis revealed that a larger shoulder internal rotation moment (r = 0.737), backwards shoulder plane of elevation moment (r = 0.614) and wrist extension moment (r = −0.564) were associated with greater racket head centre speed at racket–shuttlecock contact. Coaches should consider strengthening the musculature associated with shoulder internal rotation, plane of elevation and wrist extension. This work provides a unique analysis of the joint moments of the racket arm during the badminton jump smash performed by an elite population and highlights significant relationships between racket head speed and peak resultant joint moments.
Optimal Routing Policy in Two Deterministic Queues

We consider the problem of routing customers to one of two parallel queues where inter-arrival times and service times are deterministic. We provide an explicit formula for the average waiting time of the customers sent to one of the queues when the routing policy is an upper mechanical word. This formula is based on a special continued fraction decomposition of the service time in the queue. Using this formula we provide an algorithm computing the optimal routing policy for two queues. In general, this policy is an upper mechanical word with a rational ratio, and hence is periodic. || Dans cet article nous {etudions le routage de clients dans deux files d'attente deterministes paralleles, les temps d'interarrivees etant supposes deterministes. Nous donnons une formule explicite de la moyenne du temps d'attente des clients introduits da
Sustainability Education in China: Lessons Learnt from the Teaching of Geography

Since its emergence, the concept of sustainability has been incorporated in geography education across the globe. China is no exception. As one of the pioneer countries in advocating environmental protection, the Chinese government has called for a paradigm shift in pedagogies in order to encourage students to effectively learn the concept and develop their ability to think in new ways, especially engaging themselves with contemporary worldviews. However, many teachers may feel that they are incapable of teaching sustainability. Therefore, it is important to examine whether subject teachers have the ability to implement sustainability education. To fill this research gap, the present research focused on a case study of an in-service Chinese geography teacher teaching sustainability in a junior middle school in China. In order to deeply understand his teaching, this research adopted the form of interviews, supplemented by the analysis of relevant teaching documents. The results indicated that the two themes taught in the seventh and eighth grades, respectively, involved mainly environmental sustainability with some connection to economic sustainability, but fell short of socio-cultural sustainability. This study calls for more sustainability elements in geography curriculums, particularly with the inclusion of socio-cultural sustainability. In this article, research and practical implications have been given.
Social Context Inequality of Educational Opportunity – The Role of Performance and Choice

Equality of opportunity is a central aim in the political agenda of many nations, and political leaders consequently speak about the importance of reducing differences in educational attainment between young persons from differing social origins. Such differences are apparent at two educational steps – the transition from compulsory school to upper secondary and at the transition from upper secondary school to tertiary institutions. Both steps have to be considered if the interest lies in attainment of university degrees, since the outcome at the first transition affects that at the second. Differences in educational attainment by parental origin appear through two separate mechanisms. Children from higher origins tend to perform better at school than other children, and consequently they more than others continue to higher educational levels. However, also among children who did perform equally well, children from more advantaged origins more often than other children choose to continue to higher and more academically oriented tracks. Children of immigrants tend to perform less well at school than native-born children, but given performance, they tend more than the native-born to choose to continue in academically oriented school tracks.
Determining the mass anomalous dimension through the eigenmodes of Dirac operator

We define a scale-dependent effective mass anomalous dimension from the scaling of the mode number of the massless Dirac operator, which connects the perturbative $\gamma_m$ of an asymptotically-free system to the universal $\gamma_m^{\star}$ at a conformal fixed point. We use a stochastic algorithm to measure the mode number up to the cutoff scale on lattices as large as $48^4$. Focusing on SU(3) lattice gauge theory with $N_f = 12$ massless fundamental fermions, we examine systematic effects due to finite volumes and non-zero fermion masses. Our results suggest the existence of an infrared fixed point with $\gamma_m^{\star} \approx 0.25$. Our method provides a unique probe to study systems from the UV to the IR. It is universal and can be applied to any lattice model of interest, including both chirally-broken and IR-conformal systems.
Speech Disorders in Dysgnathic Adult Patients in the Field of Severity of Primary Dysfunction

The normative functioning of the stomatognathic system and masticatory apparatus requires specific coordination between several structures such as teeth with good occlusion, tongue without ankyloglossia or thrusting, and well-balanced facial muscles. This study aimed to evaluate the influence of non-normative primary functions such as breathing, swallowing, biting and chewing on the consonant pronunciation outcome in adults affected with facial skeletal deformities. Moreover, the authors would like to promote a new kind of speech therapy-orthognathic speech therapy. A total of 181 adults affected by skeletal class II and III malocclusion were included, along with the relationship between the malocclusion, speech deficiency (20 phonemes tested) and primary function disorders, in the subjects before and after surgical correction. The impact of surgery on pronunciation and primary function improvement and types of Polish phonemes most often misarticulated by Polish adults were also examined. Patients underwent combined treatment and received a full speech pathology examination. The treatment improved speech (p < 0.05), and primary functions (p < 0.05). Palatal, alveolar (p < 0.05), fricatives (p < 0.05), and labiodental consonant pronunciation (p < 0.05) improved. The surgical correction of malocclusion leads to better oral motor control and articulation of Polish consonants in adults.
University of Birmingham Modulation of cerebellar excitability by polarity- specific noninvasive direct current stimulation

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Evolutionary genetics of Trypanosoma and Leishmania.

– We review recent advances in the study of population structure and phylogenetic diversity of parasites belonging to the genera Trypanosoma and Leishmania. In all species properly analyzed, these parasites exhibit a basically clonal population structure, with occasional bouts of genetic exchange or hybridization, and a strong structuration of their populations into discrete evolutionary lineages. On an evolutionary scale, the impact of sex appears to be greater in African than in American trypanosomes. The taxonomic status of some Leishmania ‘species’ is questionable.
Plasma gradient of soluble urokinase-type 1 plasminogen activator receptor is linked to 2 pathogenic plasma proteome and immune 3 transcriptome and stratifies outcomes in severe 4 COVID-19 5 6

13 IICB-Translational Research Unit of Excellence, CSIR-Indian Institute of Chemical Biology, Kolkata, 14 India; Cardiorespiratory Disease Biology, CSIR-Institute of Genomics and Integrative Biology, New 15 Delhi, India; INtegrative GENomics of HOst-PathogEn (INGEN-HOPE) laboratory, CSIR-Institute of 16 Genomics and Integrative Biology, New Delhi, India; Department of Medicine, ID & BG Hospital, 17 Kolkata, India; School of Tropical Medicine, Kolkata, India; Medical College, Kolkata, India; Deben 18 Mahata Government Medical College & Hospital. Purulia, India; Academy of Scientific and 19 Innovative Research (AcSIR), Ghaziabad, India. 20 21 *These authors contributed equally 22 23
Aalborg Universitet An investigation of Danish male youth football – is something rotten in the state of Denmark? Ryom,

Objective: The purpose of this study was to investigate the presence of relative age effect (RAE) in youth football in Denmark. RAE is a well-established phenomenon in elite sports across the globe and has been heavily investigated in football, often across clubs and countries. Method: To investigate RAE in Denmark, samples were collected from recreational and all levels of youth elite level male football. Chi-squared tests were applied to determine if RAE was present. Results: Results indicate that RAE is present in Danish male recreational football (P = 0.018) and all levels of youth elite football (P ≤ 0.005). Tendencies towards RAE at elite adult level (national team) were found, but results were not significant (P = 0.227). Collectively, this study illustrates the varied impact of RAE on different levels of seniority and competition, highlighting necessity of looking at RAE on different levels to encompass the importance of the phenomenon. Furthermore, the findings of this study indicate that despite of the Scandinavian focus on both mass participation and elite, RAE is still a common phenomenon at all levels of participation.
REVIEW ARTICLE: The Hall effect in polycrystalline and powdered semiconductors

Gives a critical review of idealised two-phase geometrical models. These treatments derive expressions for the resistivity and Hall coefficient of a composite material in terms of the properties of its constituents. The authors show that these models can be applied to the interpretation of transport measurements in polycrystalline films and powder layers. Important distinctions are made depending on whether the depletion layers extend completely or partially through the grains, whether the Debye length is greater or less than the grain size and whether the mean free path is greater or less than the grain size. The authors discuss the theoretical treatment of the Hall effect in percolative systems, as geometrical models neglect percolation. The modulation of Hall coefficient and conductivity by illumination and the adsorption and desorption of ambient gases are also considered.
LIMITED COMMITMENT MODELS

We present an overview of models of long-term self-enforcing labor contracts in which risk sharing is the dominant motive for contractual solutions. A base model is developed which is sufficiently general to encompass the two-agent problem central to most of the literature, including variable hours. We consider two-sided limited commitment and look at its implications for aggregate labor market variables. We consider the implications for empirical testing and the available empirical evidence. We also consider the one-sided limited commitment problem for which there exists a considerable amount of empirical support. JEL Code: E32, J41.
Abstract. CD155/T cell immunoreceptor with Ig and ITIM domains (TIGIT) is a novel type of immune checkpoint. CD155 is an adhesion molecule that is upregulated during tumor progression and promotes the proliferative and migra-

CD155/T cell immunoreceptor with Ig and ITIM domains (TIGIT) is a novel type of immune checkpoint. CD155 is an adhesion molecule that is upregulated during tumor progression and promotes the proliferative and migratory abilities of tumor cells via various pathways. TIGIT, an inhibitory receptor, is mainly expressed on natural killer (NK), CD8+ T, CD4+ T and T regulatory (Treg) cells. CD155 transmits immune signals via interacting with the inhibitory checkpoint receptor TIGIT, thereby inhibiting the function of T and NK cells. Several preclinical studies have supported the use of TIGIT blockade as a monotherapy or combined with other immune checkpoint inhibitors for the treatment of advanced solid malignant tumors. The present review summarized the current knowledge on CD155/TIGIT and the lymphocyte-mediated inhibitory mechanism of CD155/TIGIT. An in-depth understanding of the role of CD155/TIGIT in tumors may aid to improve the application of immune checkpoint inhibitors in tumor therapy.
Incidence and Risk Factors of Depressive Symptoms in Chinese College Students

Purpose: Previous surveys have shown an increase in the prevalence of depression among college students. However, knowledge on the incidence and risk factors of depressive symptoms in Chinese college students is limited. The aim of the present study was to determine the two-year cumulative incidence of depressive symptoms in Chinese college freshmen and identified related psychosocial risk factors. Patients and Methods: A prospective survey was used to examine the cumulative incidence and risk factors of depressive symptoms (as assessed by the Centre for Epidemiological Study-Depression Scale, CES-D) among undergraduate freshmen. Five times (baseline, 5, 12, 17, and 24 months later) of self-reported data were collected from the students. Results: Of the initial 758 non-depressed respondents at baseline, 235 developed depressive symptoms (CES-D ≥ 16) during the follow-up period. The two-year cumulative incidence was estimated to be 42% and not significantly different between males and females (χ2=3.138, df =1, p=0.077). Logistic regression model showed that female gender (OR=0.43, 95% CI (0.28–0.64)), high level of self-esteem (OR=0.67, 95% CI (0.52–0.86)), and moderate exercise (OR=0.71, 95% CI (0.55–0.92)) reduced the onset of depressive symptoms; while high levels of baseline anxiety (OR=1.48, 95% CI (1.12–1.94)), Eysenck Personality Questionnaire-Neuroticism (OR=1.40, 95% CI (1.09–1.79)), concern over mistakes (OR=1.35,95% CI (1.07–1.71)), daytime sleepiness (OR=1.28, 95% CI (1.02–1.60)), mild exercise (OR=1.25, 95% CI (1.01–1.55)) increased the new onset of depressive symptoms. Conclusion: The high two-year cumulative incidence indicates that depressive symptoms are an important mental problem in Chinese college students. The present findings on the risk factors of depressive symptoms in Chinese college students may be useful for the design of student health screening and intervention programs.
Error-pronePCRofa fungal xylanase for improvementof its alkaline and thermal stability

Random mutagenesis was used to improve the alkaline and thermal stability of the xylanase (XynA) from Thermomyces lanuginosus. Error-prone PCR reactions were carried out; the PCR products were cloned into Escherichia coli and a library of 960 clones was selected on xylan-containing agar plates. The crude filtrates of positive xylanase producers were screened at 80 1C and tested separately at pH 10 for alkaline tolerance. The native XynA lost 80% activity after 90 min at 80 1C and lost 70% activity at pH 10. Conversely, the most thermostable variant, G41, retained 75% activity after 90 min at 80 1C and the best alkali-stable variant, G53, retained 93% activity at pH 10. Sequence analysis revealed four amino acid substitutions in G41 and a single substitution in G53. These variants, therefore, have improved thermal and alkaline stability and are ideal candidates for DNA shuffling experiments to produce a robust xylanase for industrial application.
Response of Strawberry to Salicylic Acid and Yeast Extract Applications under Different Nitrogen and Potassium Combinations

This study was conducted during the two successive seasons of 2011/2012 and 2012/2013 in a private farm at El–Dair village, Kalubia governorate, to investigate the response of strawberry to salicylic acid and yeast extract applications under different nitrogen and potassium fertilizers combinations. Data were recorded on vegetative growth, chemical constituents, yield and its components as well as fruit quality. Results indicate that application of mineral fertilizers at the highest used levels ( 150 kg N + 200 kg K2O or 200 kg N + 300kg K2O) per fed. combined with spraying the plants with salicylic acid at 1g/L or yeast extract 100 ml/L exhibited the highest values in the measured growth parameters i.e., plant height, number of leaves and crowns per plant, crown diameter, average leaf area as well as fresh and dry weight per plant during both seasons. Also, the same treatments gave the highest values of phosphorus, potassium and total carbohydrates during both seasons of study. Results also show that using the highest rate of N and K fertilizers (200 kg N+ 300 kg K2O) and spraying the plants with salicylic acid (1g / liter) reflected the highest produced yield and its components. Moreover, it reflected also the highest values of all determined physical and chemical fruit quality characters (average fruit length, diameter, weight and fruit firmness, TSS, Vitamin C, acidity, total sugars and anthocyanin) during both seasons . The study recommend adding 200 Kg N + 300 kg K2O per fed and spraying the plants with salicylic acid at 1g /L to enhance plant growth and increase yield and its components particularly early and exportable yield as well as physical and chemical fruit characteristics, under Kalubia governorate conditions.