Miracle-dz/UniFAR-FTUs huggingface dataset:
Stress Changes the Resting-State Cortical Flow of Information from Distributed to Frontally Directed Patterns

Despite converging evidence on the involvement of large-scale distributed brain networks in response to stress, the effect of stress on the components of these networks is less clear. Although some studies identify higher regional activities in response to stress, others observe an opposite effect in the similar regions. Studies based on synchronized activities and coactivation of these components also yield similar differing results. However, these differences are not necessarily contradictory once we observe the effect of stress on these functional networks in terms of the change in information processing capacity of their components. In the present study, we investigate the utility of such a shift in the analysis of the effect of stress on distributed cortical regions through quantification of the flow of information among them. For this purpose, we use the self-assessed responses of 216 individuals to stress-related questionnaires and systematically select 20 of them whose responses showed significantly higher and lower susceptibility to stress. We then use these 20 individuals’ resting-state multi-channel electroencephalography (EEG) recordings (both Eyes-Closed (EC) and Eyes-Open (EO) settings) and compute the distributed flow of information among their cortical regions using transfer entropy (TE). The contribution of the present study is three-fold. First, it identifies that the stress-susceptibility is characterized by the change in flow of information in fronto-parietal brain network. Second, it shows that these regions are distributed bi-hemispherically and are sufficient to significantly differentiate between the individuals with high versus low stress-susceptibility. Third, it verifies that the high stress-susceptibility is markedly associated with a higher parietal-to-frontal flow of information. These results provide further evidence for the viewpoint in which the brain’s modulation of information is not necessarily accompanied by the change in its regional activity. They further construe the effect of stress in terms of a disturbance that disrupts the flow of information among the brain’s distributed cortical regions. These observations, in turn, suggest that some of the differences in the previous findings perhaps reflect different aspects of impaired distributed brain information processing in response to stress. From a broader perspective, these results posit the use of TE as a potential diagnostic/prognostic tool in identification of the effect of stress on distributed brain networks that are involved in stress-response.
SENESCENCE OF DENDROBIUM 'POMPADOUR' FLOWERS FOLLOWING POLLINATION

SummaryFlowers of Dendrobium `Pompadour' developed premature petal and sepal senescence following pollination. Pollination induced an ethylene climacteric accompanied by a small respiratory climacteric, epinasty and increased flower or inflorescence fresh weight and water uptake. Pollination did not alter petal and sepal anthocyanin content and ion leakage, and lip, petal and sepal fresh weight and dry weight. The fresh weight and dry weight of stigmas (columns) together with pedicels increased significantly after pollination. Ovary growth of pollinated orchid flowers with petals and sepals intact was greater than that of pollinated orchid flowers without petals and sepals, while their water uptake was not significantly different.
The effects of whole-body electromyostimulation (WB-EMS) in comparison to a multimodal treatment concept in patients with non-specific chronic back pain—A prospective clinical intervention study

Background According to present guidelines, active exercise is one key component in the comprehensive treatment of nonspecific chronic back pain (NSCBP). Whole body electromyostimulation (WB-EMS) is a safe, and time-effective training method, that may be effective in NSCBP-patients. Methods In this prospective and controlled nonrandomized clinical study, two therapeutic approaches were compared. One group received 20 minutes WB-EMS per week. An active control group (ACG) received a multimodal therapy program. A third group included subjects without back pain. To all groups, the following measurement instruments were applied: Numeric Rating Scale (NRS), Oswestry Disability Index (ODI), North American Spine Society Instrument (NASS); SF 36 survey and measurements for muscular function and postural stability. In the EMS-group: T0: baseline; T1: at 6 weeks; T2: at 12 weeks and T3: at 24 weeks. In the ACG: T0 baseline and T1 after 4 weeks. Results In the intervention group, 128 patients with low back pain were enrolled, 85 in the WB-EMS group and 43 in the ACG. 34 subjects were allocated to the passive control group. The average age was 58.6 years (18–86 years). In the EMS group, the NRS (1–10) improved statistically and clinically significantly by 2 points. The ODI was reduced by 19.7 points. The NASS and most of the SF 36 items improved significantly. In the multimodal treatment group, only the muscular function improved slightly. Conclusion Our data support the hypothesis that WB-EMS is at least as effective as a multimodal treatment, which is often referred to as being the golden standard. Therefore WB-EMS may be an effective and, with 20 min./week training time, very time-efficient alternative to established multimodal treatment models.
An Ascorbic Acid Derivative 2-O--D-Glucopyranosyl-L-ascorbic Acid from the Fruit of Lycium barbarum Modulates Microbiota in Small Intestine and Colon and Exerts Immunomodulatory Effect on Cyclophosphamide-treated BALB/c Mice.

2-O--D-Glucopyranosyl-L-ascorbic acid (AA-2G) is a natural and stable ascorbic acid derivative isolated from the fruits of Lycium barbarum. In our present study, cyclophosphamide (Cy) was used to make BALB/c mice immunosuppressive, and AA-2G was used to intervene immunosuppressive mice. It was found that Cy treatment resulted in a series of changes on basic immune indexes including decrease of thymus and spleen indexes, levels of pro-inflammatory cytokines and destruction of leucocyte proportion balance, accompanying with weight loss, reduction in colon length and changes of hepatic function markers. But all these changes were reversed in varying degrees by AA-2G intervention. Notably, AA-2G could significantly change both mice colonic and small intestinal microbiota. The key responsive taxa found in mice colon were Muribaculaceae, Ruminococcaceae, Oscillibacter, Rikenella, Helicobacter, Negativibacillus, Alistipes, and Roseburia. And the key responsive taxa found in mice small intestine were Muribaculaceae, Anaerotruncus, and Paenibacillus. The results demonstrated that AA-2G could modulate microbiota in small intestine and colon and exert immunomodulatory effect. Further studies should focus on the degradation pathways of AA-2G and the interaction between AA-2G and Muribaculaceae.
Sepsis Induces Deregulation of IL-13 Production and PD-1 Expression in Lung Group 2 Innate Lymphoid Cells.

Deregulation of the immune system in sepsis plays the central role in the pathogenesis of multiple organ failure including septic lung injury. Group 2 innate lymphoid cells (ILC2 s) have emerged as a new player in regulating immune homeostasis in the lung; however, the role of ILC2 s in lung injury in sepsis remains poorly understood. Here, we investigated temporal changes in stimulatory and inhibitory receptor expression and intracellular type 2 cytokine expression of ILC2 s in the lung using a CLP mouse sepsis model. We found that IL-13 production by ILC2 s, which were predominately composed of the resident natural ILC2 subset rather than the migratory inflammatory ILC2 subset, was reduced in the lungs of sepsis mice on day 1 and gradually restored through day 7. Although the expression levels of ST2 and ICOS (stimulatory receptors) were high, IL-13 production by ILC2 s was reduced while showing high PD-1 (inhibitory receptor) expression. Furthermore, using IL-33 knockout mice, we have shown that IL-33 regulates the capacity of ILC2 to produce IL-13, possibly through the modulation of ST2 and PD-1 expression and signaling in the septic lung. To the best of our knowledge, this is the first report showing differential co-stimulatory/inhibitory receptor expression on ILC2 s in a septic lung in the context of an IL-33/IL-13 pathway-mediated type 2 immune response in the progression and resolution of inflammation. Our present findings contribute to a better understanding of the underlying immunological mechanism of ILC2 s and may fill the critical knowledge gap regarding immune homeostasis in the lung that hampers the development of new therapeutic strategies for sepsis-induced acute lung injury.
Physical Activity and Academic Achievement: An Umbrella Review

Background: This umbrella review aimed to summarise the evidence presented in systematic reviews and meta-analyses regarding the effect of physical activity on academic achievement of school-age children and adolescents. Methods: A comprehensive electronic search for relevant systematic reviews and meta-analyses were performed in Pubmed, Cochrane Library, Web of Science, Scopus, and Latin American and Caribbean of Health Sciences Information System, and reference lists of the included studies, from inception to May 2020. Studies were included if they were systematic reviews or meta-analyses, included school-age children or adolescents, the intervention included physical activity, and the outcome was the academic achievement. Two independent authors screened the text of potentially eligible studies and assessed the methodological quality of the studies using the AMSTAR 2 tool. Results: Forty-one systematic reviews and meta-analyses that examined the effects of physical activity on children and adolescents’ academic achievement were identified. Overall, the systematic reviews reported small positive or mixed associations between physical activity and academic achievement. From meta-analyses, it was observed that physical activity had null or small-to-medium positive effects on academic achievement. Chronic physical activity showed a medium positive effect on academic achievement, and acute physical activity did not demonstrate benefits. Conclusions: Physical activity seems not to be detrimental to school-age children and adolescents’ academic achievement, and may, in fact, be beneficial.
Outcomes of cataract surgery in pseudoexfoliation syndrome in England: 10-year retrospective cohort study.

PURPOSE To investigate the outcomes of cataract surgery in eyes with pseudoexfoliation syndrome in a real-world National Health Service setting. SETTING Prince Charles Eye Unit, Windsor, United Kingdom. DESIGN Single-center retrospective cohort study. METHODS All eyes that underwent phacoemulsification cataract surgery from January 2010 to December 2019 were included. Eyes with combined intraocular surgery or with a history of ocular trauma were excluded. Eyes were classified as pseudoexfoliation (n=280, 1.2%) or no pseudoexfoliation (n=23,049). The primary outcome was mean change in logarithm of the minimum angle of resolution (logMAR) visual acuity (VA). Secondary outcomes included intraoperative and postoperative complications. RESULTS The study comprised 23329 eyes of 15257 patients. Eyes in the pseudoexfoliation group were older and more likely to have multiple co-pathologies. Intraoperatively, they were more likely to experience zonular dialysis and dropped nucleus. Postoperatively, they had significantly higher rates of corneal edema, elevated intraocular pressure, postoperative uveitis, and intraocular lens subluxation, and were more likely to require a second operation within 90 days. Although the pseudoexfoliation group had worse preoperative and postoperative logMAR VA, logistic regression analysis confirmed that mean VA improvement was comparable to the reference group (mean±SD -0.49±0.52 vs -0.55±0.66, adjusted MD 0.02 (95%CI -0.01-0.06)). CONCLUSION Although patients with pseudoexfoliation had a significantly higher risk of some complications, they achieved similar VA improvements with cataract surgery compared to the non-pseudoexfoliation group. These findings will help inform the consent process and management of patient expectations.
Dietary Supplementation with Sugar Beet Fructooligosaccharides and Garlic Residues Promotes Growth of Beneficial Bacteria and Increases Weight Gain in Neonatal Lambs

The proper development of the early gastrointestinal tract (GIT) microbiota is critical for newborn ruminants. This microbiota is susceptible to modification by diverse external factors (such as diet) that can lead to long-lasting results when occurring in young ruminants. Dietary supplementation with prebiotics, ingredients nondigestible and nonabsorbable by the host that stimulate the growth of beneficial GIT bacteria, has been applied worldwide as a potential approach in order to improve ruminant health and production yields. However, how prebiotics affect the GIT microbiota during ruminants’ early life is still poorly understood. We investigated the effect of milk supplementation with a combination of two well-known prebiotics, fructooligosaccharides (FOS) from sugar beet and garlic residues (all together named as “additive”), exerted on preweaned lamb growth and the composition of their fecal microbiota, by using 16S rRNA gene amplicon high-throughput sequencing. The results showed a significant increase in the mean daily weight gain of lambs fed with the additive. Lamb fecal microbiota was also influenced by the additive intake, as additive-diet lambs showed lower bacterial diversity and were significantly more abundant in Bifidobacterium, Enterococcus, Lactobacillus and Veillonella. These bacteria have been previously reported to confer beneficial properties to the ruminant, including promotion of growth and health status, and our results showed that they were strongly linked to the additive intake and the increased weight gain of lambs. This study points out the combination of FOS from sugar beet and garlic residues as a potential prebiotic to be used in young ruminants’ nutrition in order to improve production yields.
Countermeasures for heat damage in rice grain quality under climate change

Abstract Climate change has been an increasingly significant factor behind fluctuations in the yield and quality of rice (Oryza sativa L.), particularly regarding chalky (white-back, basal-white, and milky-white) grain, immature thin grain, and cracked grain. The development and use of heat-tolerant varieties is an effective way to reduce each type of grain damage based on the existence of each varietal difference. Cultivation methods that increase the available assimilate supply per grain, such as deep-flood irrigation, are effective for diminishing the occurrence of milky-white grains under high temperature and low solar radiation conditions. The application of sufficient nitrogen during the reproductive stage is important to reduce the occurrence of most heat damage with the exception of milky-white grain. In regard to developing measures for heat-induced poor palatability of cooked rice, a sensory parameter, the hardness/adhesion ratio may be useful as an indicator of palatability within a relatively wide air–temperature range during ripening. Methods for heat damage to rice can be classified as either avoidance or tolerance measures. The timing of the measures is further divided into preventive and prompt types. The use of heat-tolerant varieties and late transplanting are preventive measures, whereas the application of sufficient nitrogen as a top dressing and irrigation techniques during the reproductive stage are prompt types which may function to lower the canopy temperature by enhancing evapotranspiration. Trials combining the different types of techniques will contribute towards obtaining more efficient and steady countermeasures against heat damage under conditions of climate change.
Factors Associated with Participation in Physical Activity Among Canadian School-Aged Children with Autism Spectrum Disorder: An Application of the International Classification of Functioning, Disability and Health

We have a limited understanding of the socioenvironmental factors associated with participation in physical activity among school-aged children with autism spectrum disorder (ASD), particularly regarding how the school environment may influence their participation. Using the International Classification of Functioning, Disability and Health (ICF) as a framework, this study examined the effect of body functions and structure, activity, and personal factors on in-school physical activity; and whether in-school physical activity, considered a socioenvironmental factor, is associated with out-of-school physical activity (i.e., participation) among elementary school-aged children (6–13 years of age) with ASD. Parents of 202 children with ASD (78.2% boys; Mage = 9.4 years) completed an online survey, as part of a larger study, to assess their child’s functioning and physical activity in- and out-of-school. Results indicated that the majority of children (85.1%) did not meet physical activity guidelines. In-school physical activities significantly predicted out-of-school physical activities including leisure-time moderate-to-vigorous physical activity (R2 = 0.27, F(10,154) = 5.67, p < 0.001) and meeting the physical activity guidelines (R2 = 0.23, Χ2 (10) = 31.9, p < 0.001). These findings underscore the importance of supporting children with ASD to be physically active in school, which may impact physical activity levels out-of-school.
How Do Molecular Dynamics Data Complement Static Structural Data of GPCRs

G protein-coupled receptors (GPCRs) are implicated in nearly every physiological process in the human body and therefore represent an important drug targeting class. Advances in X-ray crystallography and cryo-electron microscopy (cryo-EM) have provided multiple static structures of GPCRs in complex with various signaling partners. However, GPCR functionality is largely determined by their flexibility and ability to transition between distinct structural conformations. Due to this dynamic nature, a static snapshot does not fully explain the complexity of GPCR signal transduction. Molecular dynamics (MD) simulations offer the opportunity to simulate the structural motions of biological processes at atomic resolution. Thus, this technique can incorporate the missing information on protein flexibility into experimentally solved structures. Here, we review the contribution of MD simulations to complement static structural data and to improve our understanding of GPCR physiology and pharmacology, as well as the challenges that still need to be overcome to reach the full potential of this technique.
Impact of Cyanidin-3-Glucoside on Gut Microbiota and Relationship with Metabolism and Inflammation in High Fat-High Sucrose Diet-Induced Insulin Resistant Mice

The present study assessed the effects of freeze-dried cyanidin-3-glucoside (C3G), an anthocyanin enriched in dark-red berries, compared to Saskatoon berry powder (SBp) on metabolism, inflammatory markers and gut microbiota in high fat-high sucrose (HFHS) diet-induced insulin-resistant mice. Male C57 BL/6J mice received control, HFHS, HFHS + SBp (8.0 g/kg/day) or HFHS + C3G (7.2 mg/kg/day, equivalent C3G in SBp) diet for 11 weeks. The HFHS diet significantly increased plasma levels of glucose, cholesterol, triglycerides, insulin resistance and inflammatory markers. The HFHS + SBp diet increased the Bacteroidetes/Firmicutes (B/F) ratio and relative abundance of Muriculaceae family bacteria in mouse feces detected using 16S rRNA gene sequencing. The HFHS + SBp or HFHS + C3G diet attenuated glucose, lipids, insulin resistance and inflammatory markers, and increased the B/F ratio and Muriculaceae relative abundance compared to the HFHS diet alone. The relative abundances of Muriculaceae negatively correlated with body weight, glucose, lipids, insulin resistance and inflammatory mediators. Functional predication analysis suggested that the HFHS diet upregulated gut bacteria genes involved in inflammation, and downregulated bacteria involved in metabolism. C3G and SBp partially neutralized HFHS diet-induced alterations of gut bacteria. The results suggest that C3G is a potential prebiotic, mitigating HFHS diet-induced disorders in metabolism, inflammation and gut dysbiosis, and that C3G contributes to the metabolic beneficial effects of SBp.
Flexural Behavior of Composite Concrete Slabs Made with Steel and Polypropylene Fibers Reinforced Concrete in the Compression Zone

The paper presented aimed at examining the effect of a fiber-reinforced concrete layer in the compressed zone on the mechanical properties of composite fiber-reinforced concrete slabs. Steel fibers (SF) and polypropylene fibers (PP) in the amount of 1% in relation to the weight of the concrete mix were used as reinforcement fibers. The mixture compositions were developed for the reference concrete, steel fiber concrete and polypropylene fiber concrete. The mechanical properties of the concrete obtained from the designed mixes such as compressive strength, bending strength, modulus of elasticity and frost resistance were tested. The main research elements, i.e., slabs with a reinforced compression zone in the form of a 30 mm layer of concrete with PP or SF were made and tested. The results obtained were compared with a plate made without a strengthening layer. The bending resistance, load capacity and deflection tests were performed on the slabs. A scheme of crack development during the test and a numerical model for the slab element were also devised. The study showed that the composite slabs with fiber-reinforced concrete with PP in the upper layer achieved 12% higher load capacity, with respect to the reference slabs.
A Fast 3D Near Range Imaging Algorithm for a Scanning Sparse MIMO Array in the Millimeter Band

Millimeter-wave technology has been widely used in near range targets imaging scenarios, such as mechanical scanning and multiple input multiple output (MIMO) array imaging. Emerging scanning array regimes increase the need for fast-speed and high-quality imaging techniques, which, however, are often subject to specific array positions. Moreover, the relationship between array positions and the imaging performance is not clear, which leads to no uniform standard for array design. In this paper, a series of array configurations are designed to explore the impact of different array positions on the cross-range imaging performance. Meanwhile, a novel fast fully focused imaging algorithm with wavenumber domain properties is presented, which is not constrained by the positions of the transmitters and receivers. Simulation and experimental results show that, compared with a conventional algorithm, the proposed algorithm has a faster imaging speed under the same imagining quality. This study provides a feasible method for fast fully focused imaging in the case of location-constrained MIMO arrays, or partially damaged transceivers.