Miracle-dz/UniFAR-FTUs huggingface dataset:
Autoantibody Profile of a Cohort of 78 Italian Patients with Mucous Membrane Pemphigoid: Correlation Between Reactivity Profile and Clinical Involvement

Direct diagnosis of mucous membrane pemphigoid (MMP) is not easy. Circulating autoantibodies targeting bullous pemphigoid antigens of 180 kDa and 230 kDa (BP180 and BP230), α6β4 integrin, laminin 332 and type VII collagen (Col VII) are not always present. The aims of this study were to characterize the humoral immune response of a cohort of Italian patients with MMP, its association with clinical involvement and severity, and to design an algorithm for efficient serological diagnosis. Seventy-eight MMP sera were studied retrospectively by indirect immunofluorescence on salt-split skin, enzyme-linked immunosorbent assay (ELISA) and immunoblotting. Indirect immunofluorescence on salt-split skin resulted in the most sensitive approach for diagnosis of MMP. BP180 was the major autoantigen in MMP patients with oral and cutaneous involvement. Significant associations were found between BP180 reactivity and oral and cutaneous localization of the lesions ( p = 0.006), and between Col VII positivity and Setterfield severity score ( p = 0.020). indirect immunofluorescence available ELISAs, on proteins involved in dermo-epidermal or chorio-epithelial adhesion, for serological diagnosis of MMP. In major of autoantibodies C-terminal diagnoses of anti-BP180 anti-laminin type The present retrospective study characterized the humoral immune response of 78 Italian patients with MMP using standard approaches, such as IIF-SSS and commercial ELISAs, to design an algorithm for efficient serological diagnosis.
Isoëtes (Isoetaceae), Ophioglossum and Botrychium (Ophioglossaceae) in Calabria (S Italy): more karyological and taxonomical data

Abstract I. subinermis (Durieu) Cesca and Peruzzi, from a newly discovered Calabrian stand, was karyologically studied. Both chromosome number (2n = 22) and karyotype are presented. Systematic distinctiveness of I. subinermis from I. histrix Bory is confirmed. A new chromosome complement (2n = 44) is recorded for I. duriei Bory, confirming the karyological variability of this taxon. Ophioglossum lusitanicum L. (n = 120) and Botrychium lunaria L. (2n = 90) were karyologically studied too. Their chromosome numbers are reported as the first counts on Italian populations.
Flea beetle movement in a broccoli monoculture and diculture

Colonization of broccoli monocultures and broccoli–white clover dicultures by Phyllotreta cruciferae Goeze (Coleoptera: Chrysomelidae) was observed at Ithaca, N.Y. A simple continuous time model of P. cruciferae movement was developed, and instantaneous immigration and emigration rates were estimated. The movement model fit the observed colonization data extremely well ( r 2 = 0.971). Immigration was 1.3 times faster into broccoli monocultures than into dicultures, and emigration was about 2 times faster from dicultures than from monocultures. This differential movement in monocultures and dicultures resulted both from differences in host plant quality and presence or absence of white clover. Our results provide strong, direct support for Root's (1973) hypothesis that host plants are harder to find and easier to lose in vegetationally diverse habitats than in monocultures. In addition, after perturbation, population densities rapidly returned to unperturbed levels. This implies that P. cruciferae can rapidly respond to changes in its environment, which might underlie its success as a crop pest.
THE DEVELOPMENT OF SOCIOPOLITICAL CONSCIOUSNESS BY MATHEMATICS: A CASE STUDY ON CRITICAL MATHEMATICS EDUCATION IN SOUTH KOREA

This is a case study on critical mathematics education lessons in South Korea. This study explores the development of the social consciousness of students via critical mathematics lessons in which students use mathematics as a tool to analyse social issues and to justify their claims about social issues. However, student’s rarely demonstrated much development of their agency for social change after taking part in such lessons. This phenomenon is interpreted in the light of the students’ orean sociocultural background and is explained as ‘reserved agency. ’
Breeding Behavior and Early Development of Frogs of Negros, Philippine Islands

Page Page INTRODUCTION 680 Rana e. everetti 690 HISTORICAL SUMMARY 680 Rana magna visayanus 693 PRESENT STUDY 680 Rana microdisca leytensis 697 Cornufer guentheri 699 STUDY AREAS 681 Cornufer hazeli 701 CLIMATE 683 Cornufer meyeri 705 Rhacophorus leucomystax quadrilineatus 707 MATERIALS AND METHODS . 683 Rhacophorus p. pardalis 711 LIFE-HISTORIES 685 Kaloula conjuncta negrosensis . -714 Ooeidozyga 1. laevis 685 DISCUSSION 720 Rana c. cancrivora 687 LITERATURE CITED 724
Relative toxicity of insecticides against Helicoverpa armigera

Bioassay of insecticides was done to determine their LC50 values against 3 to 4 day-old larvae of H. armigera in the laboratory of Department of Entomology, RCA, Udaipur by residue film method during 2008–09 and 2009–10. The lowest LC50 values of 0.00610 and 0.006163% was recorded for flubendiamide 480 SC during 2008–09 and 2009–10, respectively. It was 11.64 to 11.85x relatively more toxic when compared to the standard check endosulfan 35 EC. Based on the LC50 and relative toxicity, the tested insecticides could be arranged in a decreasing order of toxicity as flubendiamide 480 SC > indoxacarb 14.5 SC > beta-cyfluthrin 2.5 SC > lambda-cyhalothrin 5 EC > endosulfan 35 EC.
A NEW PRAGMATIC ACCOUNT OF QUANTIFIER-SPREADING

In the study reported here, I have investigated the nature of certain interpretive errors children make with respect to universally quantified sentences well documented crosslinguistically. The aim of this line of research is to gain a better understanding of the relationship between semantics and pragmatics in children’s knowledge of quantification with a broader goal of establishing what type of knowledge is available to children from early on and what type of competence undergoes development.
Knowledge as Factor Increase Frequency of Vaginal Discharge in District Demak

ABSTRACT Incidence of abnormal vaginal discharge is high in developing countries. Abnormal vaginal discharge is symptom of reproductive tract infections and sexual transmitted diseases. Knowledge vaginal discharge important for prepare and preventive abnormal vaginal discharge and improving practice hygiene sanitary. The study propose correlation knowledge of vaginal discharge with frequency of vaginal discharge. Study design was cross-sectional, sample were collected 60 participant. Data were collecting with interview by questioner. Data were analysis SPSS under 0.05 regarded as statistically significant with pearson correlation. Mean score of indicators definition 73,05±17,11, caused 81,11±12,82, prevention 63,83±16,06, impact 60,74±16,92, and total knowledge 60,74±16,92. Indicator of definition no significant correlation with vaginal discharge p = 0,072, indicators of caused significant correlation with vaginal discharge p = 0,002, indicators of preventive no significant correlation with vaginal discharge p = 0,067, indicators of impact significant correlation with vaginal discharge p = 0,032. Total knowledge significant correlation with vaginal discharge p = 0,005. Knowledge of vaginal discharge average high, indicators dominant is caused compare other indicators. Knowledge was significant correlation with vaginal discharge. Keywords : vaginal discharge, knowledge, adolescent.
Neonatal Outcomes from Mothers with Hypertension Disorders of Pregnancy: A Retrospective Study at a Referral Hospital in Rwanda

Background Globally, maternal hypertensive disorders in pregnancy significantly increase both maternal and perinatal morbidity and mortality. Maternal hypertension affects 14 percent of pregnancies. Eearly detection and management are critical for improving the health outcomes of both mother and neonate. Objective To assess the association between maternal hypertension disorders in pregnancy and immediate neonatal outcomes at a University Teaching Hospital in Rwanda. Methods A retrospective study of maternal files with hypertension disorders was conducted from January 1, 2016, to March 31, 2019. A census sample of 114 records and pretested checklist was used to collect data. Descriptive statistics were used to analyze associations between maternal factors and immediate neonatal outcomes. Results Neonatal outcomes included low birth weight (75.4%), prematurity (59.6%), admission to neonatal intensive care unit (50.4%), intrauterine growth restriction (32.4%), and neonatal death (22.8%). Nearly two-thirds (62%) of mothers had preeclampsia. Significant associations with immediate neonatal outcomes included gestational age, medical history, delivery mode, maternal referral status, preterm birth, prematurity, and abortion. Conclusion Maternal hypertensive disorders were significantly associated with adverse neonatal outcomes in our study population in Rwanda. Improving early detection, health education, and management of hypertensive disorders in pregnancy is critical to reduce maternal and neonatal morbidity and mortality. Rwanda J Med Health Sci 2020;3(2):193-203
Central Chilean Patagonia ( Lake Shaman , 44 S )

A 19 cal ka BP pollen and charcoal record from Lake Shaman (44 S; 71 W, Chile) was analyzed to establish vegetation, fire and climate dynamics of the forest-steppe ecotone in Central Chilean Patagonia. Lake Shaman record indicates that the upper Río Cisnes valley was free of ice at around 19 cal ka BP. From this date and until 14.8 cal ka BP, a grass steppe with high proportions of shrubs associated to colder and drier conditions than present developed in this area. A continuous increase of Nothofagus accompanied by a decline in the steppe shrubs and sudden dominance of paludal over aquatic plants from 11 cal ka BP was associated to effective moisture increase but still under modern values. The replacement of the colddry grass-shrub steppe by a similar-than-present forest-steppe ecotone suggests an increase in temperature indicating the onset of the Holocene. At the same time, moderate fire activity suggested by the charcoal record could be related to major fuel availability as consequence of Nothofagus forest expansion. Between 8 and 3 cal ka BP, the record indicates the easternmost position of the forest-steppe ecotone suggesting the highest effective moisture with the establishment of seasonality between 5 and 3 cal ka BP. From 3 cal ka BP, the record indicates a retraction of the forest-steppe ecotone accompanied by a high pollen record variability and an increased fire activity. These late changes suggest decreased effective moisture associated with a high climatic variability. At regional and extra-regional scale, climatic changes at Lake Shaman’s record are mostly associated to changes (latitudinal shifts and/or strengthening/weakening) of past Southern Westerlies that were previously recorded along Patagonia from the Lateglacial to the mid-Holocene. During the Late Holocene, a regional pattern characterized by high record variability emerges throughout Central Chilean Patagonia. This variability would be related to (1) low magnitude Southern Westerlies changes probably associated to ENSO and/or SAM or (2) the complex relationships between vegetation, fire and human occupations during the last 3 cal ka. 2012 Elsevier Ltd. All rights reserved.
H2SO4–H2O binary and H2SO4–H2O–NH3 ternary homogeneous and ion-mediated nucleation: lookup tables version 1.0 for 3-D modeling application

Abstract. Formation of new particles in the atmosphere has important implications for air quality and climate. Recently, we have developed a kinetically based H2SO4–H2O–NH3-ion nucleation model which well captures the absolute values of nucleation rates as well as dependencies of nucleation rates on NH3 and H2SO4 concentrations, ionization rates, temperature, and relative humidity observed in the well-controlled Cosmics Leaving Outdoor Droplets (CLOUD) measurements. Here we employ the aforementioned recently developed kinetic nucleation model to generate nucleation rate lookup tables for H2SO4–H2O binary homogenous nucleation (BHN), H2SO4–H2O–NH3 ternary homogeneous nucleation (THN), H2SO4–H2O-ion binary ion-mediated nucleation (BIMN), and H2SO4–H2O–NH3-ion ternary ion-mediated nucleation (TIMN). A comparison of nucleation rates calculated using the lookup tables with CLOUD measurements of BHN, BIMN, THN, and TIMN is presented. The lookup tables cover a wide range of key parameters controlling binary, ternary, and ion-mediated nucleation in the Earth's atmosphere and are a cost-efficient solution for multidimensional modeling. The lookup tables and FORTRAN codes, made available through this work, can be readily used in 3-D modeling. The lookup tables can also be used by experimentalists involved in laboratory and field measurements for a quick assessment of nucleation involving H2SO4, H2O, NH3, and ions.
The eye lens as an indicator of age in the wild rabbit in Australia

The weights of dried eye-lenses collected from 71 free-living Australian wild rabbits, Oryctolagus cuniculus (L.), of known age have been subjected to statistical treatment. It has been found that the weight of the eye-lens is a reliable indicator of a rabbit's age up to approximately 150 days. A suitable transformation has been suggested for analysis of the relation between weights of organs and age of growing animals.
Adversarial Argument , Agency , and Vulnerability

We address the position that the speech act of argument necessarily constitutes an adversarial interaction because of the arguer’s intent and ability to cause involuntary and costly belief change in the audience. This position proves problematic in neglecting the diversity of arguer intentions, the significant benefits that audiences receive from arguments, and the agency of the audience in belief change. The alternative of invitational rhetoric, designed to bypass negative effects of adversarial interactions in persuasion, demonstrates how audiences exercise agency. However, a general accounting for the complex impact of arguments on audiences and on arguers demands attention to the vulnerabilities involving various forces of argument, not just to the intellectual force of premise-conclusion complexes. Addressing vulnerability points to a holistic view of argument involving adversarial and non-adversarial elements, diverse intentions, and an array of costs and benefits to arguers and audiences alike.
Projected climate change implications for the South Australian flora

South Australia has warmed since 1950 and further temperature increases are forecast this century. We explore the implications of climatic warming for individual plant species and the State’s plant biodiversity, which is significant and includes 418 endemic taxa. Environmental constraints and interspecific interactions operate on species to determine which survive in which environment, with resulting compositional signatures. Climate change influences such ‘filtering’ processes via mechanisms such as altered mortality or recruitment rates and indirectly through fire regimes. While modest environmental changes can be absorbed within a given ecological community, significant change will eventually drive species turnover. We use the Hopbush, Dodonaea viscosa subsp. angustissima (DC.) J.G. West as a case study that shows morphological adaptations to arid conditions (narrower leaves and higher stomatal densities), observed in more northern populations in South Australia. Leaves of this species have narrowed through time in conjunction with climatic warming, matching predictions from the spatial cline. Genomic sequencing has also revealed genetic correlations with temperature and aridity, suggesting key climate change variables are impacting the selection of functional genes including those linked to leaf characters. Despite such adaptations in individual species, plant community composition is sensitive to small changes in climate. As a result, predicted climatic changes may ultimately drive complete species turnover, if the more severe scenarios are realised. Spatial analysis highlights a climatic transition zone, between desert and Mediterranean South Australia, where community composition changes more rapidly with climate and this area is therefore likely to be more vulnerable to climate change. Notwithstanding potential evolutionary adaptation, significant climate change will influence ecophysiology, leading to changes in primary productivity and water stress and is predicted to ultimately lead to lower species richness, altered species composition and more uneven abundances. Although we have an empirical understanding of climate sensitivity for South Australian plant communities, we need sophisticated ecological forecasting that considers complex interactions with fire, habitat configuration and evolutionary adaptation.
ePubWU Institutional Repository

A new technology is a bold new combination of production factors that potentially yields a higher level of total factor productivity. The optimal combination of input factors is unknown when an innovation is pursued. A larger targeted innovation may require a greater change in the optimal combination of production factors employed and increases volatility alongside with economic growth. We show that economic policy can interfere in this relationship with by adjusting source based capital income taxes.
Wright, N and Pickles, A and Braithwaite, EC and Sharp, H and Hill, J (2019)Sex-dependent associations between maternal prenatal cortisol and child callous-unemotional traits: Findings from the Wirral Child Health and Development

Background: Elevated maternal glucocorticoids during pregnancy may impact on fetal development in a sexdependent way, leading to increased amygdala activation and increased risk for internalising disorders in females. Based on evidence implicating reduced amygdala activation in callous-unemotional (CU) traits, we predicted that elevated maternal cortisol in pregnancy would be associated with lower CU traits and elevated anxious-depressed symptoms, only in girls. Methods: Participants were 225 members of a stratified subsample within an epidemiological longitudinal cohort (WCHADS). Salivary cortisol was measured over two days at 32 weeks gestation (on waking, 30-min postwaking and during the evening) and the log of the area under the curve (LogAUC) was calculated as an index of diurnal cortisol. Mothers reported on child CU traits and anxious-depressed symptoms at 2.5, 3.5 and 5.0 years of
Online misinformation about climate change

Policymakers, scholars, and practitioners have all called attention to the issue of misinformation in the climate change debate. But what is climate change misinformation, who is involved, how does it spread, why does it matter, and what can be done about it? Climate change misinformation is closely linked to climate change skepticism, denial, and contrarianism. A network of actors are involved in financing, producing, and amplifying misinformation. Once in the public domain, characteristics of online social networks, such as homophily, polarization, and echo chambers—characteristics also found in climate change debate—provide fertile ground for misinformation to spread. Underlying belief systems and social norms, as well as psychological heuristics such as confirmation bias, are further factors which contribute to the spread of misinformation. A variety of ways to understand and address misinformation, from a diversity of disciplines, are discussed. These include educational, technological, regulatory, and psychological‐based approaches. No single approach addresses all concerns about misinformation, and all have limitations, necessitating an interdisciplinary approach to tackle this multifaceted issue. Key research gaps include understanding the diffusion of climate change misinformation on social media, and examining whether misinformation extends to climate alarmism, as well as climate denial. This article explores the concepts of misinformation and disinformation and defines disinformation to be a subset of misinformation. A diversity of disciplinary and interdisciplinary literature is reviewed to fully interrogate the concept of misinformation—and within this, disinformation—particularly as it pertains to climate change.
Overview and revision of the extant genera and subgenera of Trogidae (Coleoptera : Scarabaeoidea)

Extant genera and subgenera of the Trogidae (Coleoptera: Scarabaeoidea) are reviewed. Contemporary classifications of this family have been based exclusively on morphological characters. The first molecular phylogeny for the family recently provided strong support for the relationships between morphologically defined genera and subgenera. On the basis of morphological, molecular and biogeographical evidence, certain taxonomic changes to the genus-level classification of the family are now proposed. The family is confirmed as consisting of two subfamilies, Omorginae Nikolajev and Troginae MacLeay, the former with two genera, Omorgus Erichson and Polynoncus Burmeister, and the latter with two genera, Trox Fabricius and Phoberus MacLeay stat. rev. Phoberus is restored to generic rank to include all Afrotropical (including Madagascan endemic) species; Afromorgus is confirmed at subgeneric rank within the genus Omorgus ; and the monotypic Madagascan genus Madagatrox syn. n. is synonymised with Phoberus. The current synonymies of Pseudotrox Robinson (with Trox ), Chesas Burmeister, Lagopelus Burmeister and Megalotrox Preudhomme de Borre (all with Omorgus ) are all accepted to avoid creating speculative synonyms before definitive phylogenetic evidence is available. New combinations resulting from restoring Phoberus to a monophyletic genus are listed in Appendix A.
JAK Inhibitors in Rheumatoid Arthritis: An Evidence-Based Review on the Emerging Clinical Data

Abstract Janus kinase (JAK) Inhibitors are the latest drug class of disease-modifying medication to emerge for the treatment of rheumatoid arthritis (RA). They are a small molecule-targeted treatment and are the first oral option to compare favourably to existing biologic disease-modifying anti-rheumatic drugs (DMARDs). Tofacitinib, baricitinib and upadacitinib are the first 3 JAK inhibitors to become commercially available in the field and are the core focus of this review. To date, they have demonstrated comparable efficacy to tumour necrosis factor (TNF) inhibitors in terms of American College of Rheumatology (ACR) response rates and disease activity (DAS28) scores with similar cost to the benchmark adalimumab. This narrative review article aims to synthesise and distil the key available trial data on JAK inhibitor efficacy and safety, along with their place in the ACR and European League Against Rheumatism (EULAR) guidelines for RA. The novel mechanism of action of the JAK/STAT pathway is highlighted along with the potential effects of modulating each pathway. The rapid onset of action, role in attenuation of central pain processing and effect on structural damage and radiographic progression are also all examined in detail. We also explore the latest meta-analyses and comparative performance of each of the 3 available JAKs in an effort to determine which is most efficacious and which has the most favourable safety profile. Post marketing concerns regarding thromboembolism risk and herpes zoster infection are also discussed. Additionally, we review the cost-benefit analyses of the available JAK inhibitors and address some of the pharmacoeconomic considerations for real-world practice in the UK and US by detailing the raw acquisition cost and the value they provide in comparison to the benchmark biologic adalimumab and the anchor DMARD methotrexate.