Miracle-dz/UniFAR-FTUs huggingface dataset:
Assessing the relative effects of emissions, climate means, and variability on large water supply systems

Some of the greatest societal risks of climate change rise from the potential impacts to water supply. Yet prescribing adaptation policies in the near term is made difficult by the uncertainty in climate projections at relevant spatial scales and the conflating effects of uncertainties in emissions, model error, and internal variability. In this work, a new framework is implemented to explore the vulnerability of reservoir systems in the northeastern U.S. to climate change and attribute vulnerabilities to changes in mean climate, natural variability, or emission scenarios. Analysis of variance is used to explore the contributions of uncertainties to system performance. Diagnosing the relative risks to water supply will help water resource engineers better adapt to uncertain future conditions. The results indicate that uncertainty in water supply system performance can be attributed mostly to uncertainty in internal variability over policy‐relevant planning horizons, and thus, adaptation efforts should focus on managing variability.
Hand pose selection in a bimanual ﬁ ne-manipulation task

Many daily tasks involve the collaboration of both hands. Humans dexterously adjust hand poses and modulate the forces exerted by ﬁ ngers in response to task demands. Hand pose selection has been intensively studied in unimanual tasks, but little work has investigated bimanual tasks. This work examines hand poses selection in a bimanual high-precision-screwing task taken from watchmaking. Twenty right-handed subjects dismounted a screw on the watch face with a screwdriver in two conditions. Results showed that although subjects used similar hand poses across steps within the same experimental conditions, the hand poses differed signi ﬁ cantly in the two conditions. In the free-base condition, subjects needed to stabilize the watch face on the table. The role distribution across hands was strongly in ﬂ uenced by hand dominance: the dominant hand manipulated the tool, whereas the nondominant hand controlled the additional degrees of freedom that might impair performance. In contrast, in the ﬁ xed-base condition, the watch face was stationary. Subjects used both hands even though single hand would have been suf ﬁ cient. Importantly, hand poses decoupled the control of task-demanded force and torque across hands through virtual ﬁ ngers that grouped multiple ﬁ ngers into functional units. This preference for bimanual over unimanual control strategy could be an effort to reduce variability caused by mechanical couplings and to alleviate intrinsic sensorimotor processing burdens. To afford analysis of this variety of observations, a novel graphical matrix-based representation of the distribution of hand pose combinations was developed. Atypical hand poses that are not documented in extant hand taxonomies are also included.
The Abilities of Different Lactic Acid Bacterial Stains to Deplete Nitrite Level in MRS and M17 Broth

Nitrite is still regarded as essentially undesirable in foods. Therefore, it is necessary to keep its concentration under control for food safety. The current study was conducted to evaluate the ability of two reference lactic acid strains to deplete nitrite. Lactobacillus acidophilus ROO52 and Streptococcus thermophiles YC-180 were examined in De Man Rogosa and Sharpe (MRS) and M17 broth with standard sodium nitrite at 0.10 mg /mL and 1 mL (10-8 cells per mL) for each of the reference strains to determine the ability of these strains to eliminate nitrite during the fermentation period. A control group, MRS and M17 broth and standard nitrite without inoculum were used. The nitrite depletion was determined by a UV-Vis spectrophotometer. After 48 hours of fermentation, there were significant differences between residual nitrite levels of broth inoculated by Streptococcus thermophiles YC-180 compared to control and Lactobacillus acidophilus ROO52. Streptococcus thermophiles YC-180 depleted nitrite levels significantly (P˂0.05) from the initial concentration (0.10 mg/ml) to 0.02 mg/ml with a percentage (45%) after 48 hours compared to control and Lactobacillus acidophilus ROO52, which depleted nitrite levels from the initial concentration of 0.10 mg/ml to 0.04 mg/ml with a percentage (22.5%) after 48 hours. In conclusion, Streptococcus thermophiles YC-180 was more effective at nitrite depletion than Lactobacillus acidophilus ROO52. The reduction of nitrite occurs due to acid production and the enzymatic action of these bacteria.
Granite erratics in Beacon Valley, Antarctica

Abstract We present the first quantitative attempt at reconciling the source and emplacement of granite erratics in Beacon Valley. The erratics are enigmatic because granite does not crop out in the valley and its nearest subaerial exposure is at least 10 km downstream to the east of the valley. Detailed mapping of the valley shows three types of granite erratics, which are not present in equal amounts and do not show spatial patterns. Pb isotopic and elemental compositions of the erratics eliminate the Metschel Tillite as a source and indicate they derive from the Dry Valley plutons. Our limited study tentatively ties the erratics to suites of plutons, but it does not allow a direct tie of the erratics to specific plutons because of i) the geochemical variability of the plutons and ii) the limited number of erratics that were analysed. Published data suggest the erratics provide evidence of wet-based glaciation, which covered the Dry Valleys and much of Antarctica during the mid-Miocene. Our paper also explains the problems associated with the emplacement of these erratics and the age of the massive ice in Beacon Valley.
Frequent Storm Surges Affect the Groundwater of Coastal Frequent Storm Surges Affect the Groundwater of Coastal Ecosystems Ecosystems

The effects of the 2004 Abstract Recent studies have focused on the effect of large tropical cyclones (hurricanes) on the shore, neglecting the role of less intense but more frequent events. Here we analyze the effect of the offshore tropical storm Melissa on groundwater data collected along the North America Atlantic coast. Our meta-analysis indicates that both groundwater level and specific conductivity significantly increased during Melissa, respectively reaching maximum values of 1.09 m and 25.2 mS/cm above pre-storm levels. Time to recover to pre-storm levels was 10 times greater for groundwater specific conductivity, with a median value of 20 days, while groundwater level had a median recovery time of 2 days. A frequency-magnitude analysis indicates that the percent of time with salinization is higher for Melissa than for energetic hurricanes. Given the high frequency of these events (return period of 1–2 years), and the long time needed for groundwater conditions to return to normal levels, we conclude that increasingly frequent moderate storms will have a significant impact on the ecology of vegetated shorelines.
Future impacts of climate variability, climate change and land use change on water resources in the Murray Darling Basin: Overview and Draft Program of Research

The Intergovernmental Panel on Climate Change has nominated the impacts of climate change on water as a key issue for Australia. Under current climate, the Murray-Darling Basin (MDB) is affected by large climate variability, high water-use as a proportion of total streamflow and competing demands for water. Climate change is expected to impact on runoff and streamflow, but large uncertainties have hampered planning of practical steps to manage these impacts. The possibility that already limited environmental flows and plans to recover some of these flows in the MDB may be threatened by climate change is investigated through three avenues: • Climate change projections for Australia, recently released by CSIRO, are re-investigated for the MDB. • Conclusions from recent impact modelling and risk assessment on flows and water use in the Macquarie River catchment are used to infer possible basin-wide changes. • The impacts of climate variability and land-use change in combination with climate change are described.
MYC disrupts transcriptional and metabolic circadian oscillations in cancer and promotes enhanced biosynthesis

The molecular circadian clock, which controls rhythmic 24-hour oscillation of genes, proteins, and metabolites in healthy tissues, is disrupted across many human cancers. Deregulated expression of the MYC oncoprotein has been shown to alter expression of molecular clock genes, leading to a disruption of molecular clock oscillation across cancer types. It remains unclear what benefit cancer cells gain from suppressing clock oscillation, and how this loss of molecular clock oscillation impacts global gene expression and metabolism in cancer. We hypothesized that MYC or its paralog N-MYC (collectively termed MYC herein) suppress oscillation of gene expression and metabolism to upregulate pathways involved in biosynthesis in a static, non-oscillatory fashion. To test this, cells from distinct cancer types with inducible MYC were examined, using time-series RNA-sequencing and metabolomics, to determine the extent to which MYC activation disrupts global oscillation of genes, gene expression pathways, and metabolites. We focused our analyses on genes, pathways, and metabolites that changed in common across multiple cancer cell line models. We report here that MYC disrupted over 85% of oscillating genes, while instead promoting enhanced ribosomal and mitochondrial biogenesis and suppressed cell attachment pathways. Notably, when MYC is activated, biosynthetic programs that were formerly circadian flipped to being upregulated in an oscillation-free manner. Further, activation of MYC ablates the oscillation of nutrient transporter proteins while greatly upregulating transporter expression, cell surface localization, and intracellular amino acid pools. Finally, we report that MYC disrupts metabolite oscillations and the temporal segregation of amino acid metabolism from nucleotide metabolism. Our results demonstrate that MYC disruption of the molecular circadian clock releases metabolic and biosynthetic processes from circadian control, which may provide a distinct advantage to cancer cells.
The Aquila Digital Community The Aquila Digital Community

Background: The aggregates of a protein called, ‘ A b ’ found in brains of Alzheimer ’ s patients are strongly believed to be the cause for neuronal death and cognitive decline. Among the different forms of A b aggregates, smaller aggregates called ‘ soluble oligomers ’ are increasingly believed to be the primary neurotoxic species responsible for early synaptic dysfunction. Since it is well known that the A b aggregation is a nucleation dependant process, it is widely believed that the toxic oligomers are intermediates to fibril formation, or what we call the ‘ on-pathway ’ products. Modeling of A b aggregation has been of intense investigation during the last decade. However, precise understanding of the process, pre-nucleation events in particular, are not yet known. Most of these models are based on curve-fitting and overlook the molecular-level biophysics involved in the aggregation pathway. Hence, such models are not reusable, and fail to predict the system dynamics in the presence of other competing pathways. Results: In this paper, we present a molecular-level simulation model for understanding the dynamics of the amyloid-b (A b ) peptide aggregation process involved in Alzheimer ’ s disease (AD). The proposed chemical kinetic theory based approach is generic and can model most nucleation-dependent protein aggregation systems that cause a variety of neurodegenerative diseases. We discuss the challenges in estimating all the rate constants involved in the aggregation process towards fibril formation and propose a divide and conquer strategy by dissecting the pathway into three biophysically distinct stages: 1) pre-nucleation stage 2) post-nucleation stage and 3) protofibril elongation stage. We next focus on estimating the rate constants involved in the protofibril elongation stages for A b 42 supported by in vitro experimental data. This elongation
Challenges to integrating planning and policy-making with environmental assessment on a regional scale – a multi-institutional perspective

Abstract Regional environmental assessment (EA) requires the participation of policy- and plan-making institutions to formulate, implement and monitor regional environmental management strategies. However, there is little understanding of what effective integration is in the context of regional EA and from the perspectives of planners and policy-makers involved. This paper seeks to explore how institutional actors perceive cross-domain integration vis-à-vis their own involvement in regional EAs. Thirty-eight participants from four regional EA initiatives in Canada shared their perspectives in an online survey. Three types of silo effects are identified: (1) institutional – intricately linked to factors such as coordination, goals and expectations, leadership and capacity; (2) disciplinary – characterized by limited communication and scepticism around data sharing; and (3) transactional – tendency of actors to emphasize individual narrow perspective rather than collective social and environmental outcomes. Additional findings reveal the importance of learning and multiple domain expertise as opportunities for enhancing cross-domain integration in regional EA practice. Finally, the study concludes that proactive consideration of potential silo effects is necessary for improved regional EA outcomes, and to facilitate more effective regional resource governance.
Psychometric evaluation of the Persian version of the perception of conscience questionnaire in Iranian nurses

Conscience is defined as the cornerstone of ethics and is considered a valuable asset. There is, however, little evidence about how Iranian nurses perceive conscience. The purpose of this study was to psychometrically evaluate the Persian version of the Perception of Conscience Questionnaire (PCQ) in Iranian nurses. In this cross-sectional and descriptive study, a psychometric evaluation of the PCQ was conducted on Iranian nurses in 2022. A total of 300 nurses participated in this study to validate the PCQ. At first, the initial translation and determination of face validity was done, and content validity was assessed using the Content Validity Index and Content Validity Ratio. Reliability was determined by intra-class correlation coefficient and Cronbach's alpha coefficient. The construct validity of the PCQ was determined by exploratory factor analysis, which led to the extraction of five factors of warning signal, valuable asset, spiritual power, burden and conscience outcomes from the initial 14 factors of the questionnaire. Reliability of the whole questionnaire was calculated to be 0.80 using Cronbach's alpha. While an intra-class correlation coefficient of 0.58 indicated average stability, the five-factor construct of the PCQ showed good validity and reliability. Therefore, our findings proved that this tool is suitable for assessing Iranian nurses’ perception of conscience.
Relationship between hospital work environment and nurses’ performance in critical setting

Background: The context of health care delivery is rapidly changing. Such, care delivery is affected by the complexity of diseases, and technological development, all of which increase demands for high quality of care worldwide. So the nurses ‟ work environment is getting global interest because there is a growing consensus that identifying opportunities for improving working conditions in hospitals. So the aim of this research was to assess the relationship between hospital work environments on nurses ‟ performance in critical setting. Research design: A descriptive correlational design was utilized in the current research. Setting: The research was conducted at General Minia Hospital. Sample: Nurses worked on critical care units (no.95). Tools of data collection: Two tools, the first tool was nurses ‟ work environment tool and the second tool was observational nursing performance. Results: These findings revealed that the majority of nurses had bad work as well as unsatisfactory performance. Conclusion: There were positive correlation between nurse ‟ s work environment and their performance (p= 0.002**) Recommendations: Enhance a supportive work environment by the nurse manager as effective way to increase nurses ‟ psychological bonding and enhancing positive work-related outcomes that may, in turn, enhance their performance.
Notes and Correspondence Abundant Landslides Associated with Extreme Weather Change during the 2009 Typhoon Morakot

The abundance of landslides that occurred in Taiwan in August of 2009 is not only attributed to extremely heavy rainfall but also extreme weather change from a dry period that occurred one month before the landslides to extremely heavy rainfall within a few days when Typhoon Morakot passed through Taiwan. The dry month of July in the summer of 2009 followed several months of rainfall shortage. Numerous cracks and fissures would have developed in the ground surface. Those cracks and fissures enabled the heavy rainfall to easily infiltrate the ground, thus constituting another factor causing a huge number of landslides in southern Taiwan. Thus, warning against abundant landslides might be considered in the future as extremely heavy rainfall can occur during the hot, dry summer season.
Age of the Yarrabee and accessory tuffs: implications for the upper Permian sediment-accumulation rates across the Bowen Basin

ABSTRACT The Yarrabee Tuff is a stratigraphically significant marker across the Bowen Basin separating the Fort Cooper–Burngrove–Fair Hill formations from the overlying Rangal and equivalent coal measures. At least three to four persistent tuffs (referred here as accessary tuffs) beneath the Yarrabee Tuff were recognised in the Fort Cooper Coal Measures as suitable for regional stratigraphic correlations. In this study, we determined the ages of the Yarrabee and accessary tuffs across different morphotectonic zones of the basin through high-precision U–Pb dating of zircon with the CA-IDTIMS technique. The age of the Yarrabee Tuff is found to be 252.69 ± 0.16 Ma in the Duckworth 11 well, 253.07 ± 0.22 Ma in the Crocker Gully 2 well and <252.58 ± 0.23 Ma in the Peat 1 well. The age range of the Yarrabee Tuff coincides with the previously published date of the Kaloola Tuff Member in Meeleebee 5 suggesting that the tuffs are stratigraphically equivalent. The age range for the accessory tuff 1 is 253.12 ± 0.12 Ma to 252.85 ± 0.16 Ma, 253.45 ± 0.08 Ma for accessory tuff 2 and 253.77 ± 0.17 Ma to 253.57± 0.18 Ma for accessory tuff 3, placing them in the upper Changhsingian Stage. The age of the accessory tuff 6 (less laterally consistent in the basin) from the Fair Hill Formation is 254.03 ± 0.03 Ma, placing it in the lower Changhsingian Stage. The age-constrained intervals allow the estimation of sedimentation rates using decompacted coal and clastic sediment thickness. In the Taroom Trough, the temporal variation in sedimentation rates is found to be 902 m/Ma in the Fair Hill Formation decreasing to 234.5 m/Ma in the overlying Burngrove Formation, reflecting a decrease in accommodation or sediment supply upwards in the sequence. Across the basin, the sedimentation rates for the Burngrove Formation are consistently higher in the Taroom Trough ranging between 234.5 and 224.5 m/Ma and lower rates of 112 m/Ma in the Roma Shelf. This regional variation reflects areas of high sedimentation rates that are high accommodation sites recognised by split coal seams and increased interburden. Conversely, low sedimentation rates reflect low accommodation sites, such as the Roma Shelf and the Burunga Anticline that are characterised by coalesced coal seams. The results help to understand stratal relationships across variable accommodation sites, basin-fill history of the basin including extent of sediment supply and paleotopographic controls during the evolution of the Bowen Basin. We also discuss criteria for interpreting the results of CA-IDTIMS U–Pb dating and consider the possible geological uncertainties related to either the primary magmatic processes or secondary reworking of tuffs at the site of deposition.
Digital Commons @ East Tennessee State University Digital Commons @ East Tennessee State University

Depressive symptoms are common in individuals with multiple sclerosis (MS), and are frequently exacerbated by pain; however, spiritual well-being may allow persons with MS to more effectively cope with pain-related deficits in physical and role functioning. We explored the associations between spiritual well-being, pain interference and depressive symptoms, assessing each as a potential mediator, in eighty-one patients being treated for MS, who completed self-report measures: Functional Assessment of Chronic Illness Therapy-Spiritual Well-Being Scale, Pain Effects Scale, and Center for Epidemiologic Studies Depression Scale Revised. At the bivariate level, spiritual well-being and its subscale of meaning and peace were negatively associated with depression and pain interference. In mediation models, depression was not related to pain interference via spiritual well-being, or to spiritual well-being via pain interference. Pain interference was related to depression via spiritual well-being and meaning/peace, and to spiritual well-being and meaning/peace via depressive symptoms. Finally, spiritual well-being and meaning/peace were related to depression via pain interference, and to pain interference via depressive symptoms. For patients with MS, a multi-faceted approach to treatment that includes pain reduction and promotion of spiritual well-being may be beneficial, although amelioration of depression remains a critical task.
Influence of Jets on [O iii] Extensions in Green Pea/Bean Galaxies

We present a study investigating the influence of jets on galaxies exhibiting strong [O iii]λ5007 emission, known as Green Peas and Green Beans. Our sample comprised 12 nearby sources (z ∼ 0.04–0.1, six with jets and six without jets) with high [O iii] luminosity (L ∼ 1040 erg s−1), selected from a radio-selected galaxy sample observed with the Sloan Digital Sky Survey and Radio Sky at Twenty-centimeters survey. We perform Large Binocular Telescope–Multi-Object Double Spectrograph long-slit spectroscopy at two position angles for each galaxy: one aligned with the jet direction and another perpendicular to it. By tracing the [O iii] emission along these slits, we aimed to assess the extension of the narrow line region and examine the impact of jets. Surprisingly, our analysis revealed no preferred direction for the extension of the [O iii] emission, indicating that jets have a limited influence on the extended emission line regions (EELRs). This also suggests the possibility of missed detection of conical-shaped EELRs aligned with the jets, attributable to our slit orientations. Furthermore, we compared the extension of [O ii] emission, which traces star-forming regions, with that of [O iii]. We observed a significant difference, with [O ii] exhibiting a considerably greater extension along the galactic plane. This suggests a stronger association of [O ii] emission with stellar processes.