Miracle-dz/UniFAR-FTUs huggingface dataset:
Framework to Optimize Profitability of Private Sector Banks in India

Indian private sector banking stocks have been among the best performers on the Indian stock exchanges over the last decade. Private sector banks have experienced a major recovery in their asset quality over the last three years after significant fall in asset quality in the 10-year period following the great recession of 2008. This has contributed to immense volatility in the profitability of these banks. Given the important role played by private sector banks in fueling growth of the Indian economy, it would be useful to understand the important drivers of private sector bank profitability. This paper examined the influence of some key micro and macro determinants on the profitability of India's largest private sector banks over a 14-year period from 2009-2022 using panel regression models. Measures of asset quality, income, liquidity, and productivity proved to be microeconomic determinants of profitability. Interest rates, exchange rates, and inflation proved to be the macroeconomic determinants of profitability. A framework to optimize profitability of these banks is presented which will benefit key stakeholders of these banks.
Is it Worth the Money? The Functionality of Engineered Shallow Stream Banks as Habitat for Juvenile Fishes in Heavily Modified Water Bodies

Heavily modified water bodies (HMWB) are characterized by monotonous and straightened channel morphologies with high degrees of bank enforcement. They often lack shallow bank habitats, which are considered important for critical life stages of fishes. In this study, three principle options to engineer shallow stream zones were assessed concerning the value of the created habitats for larval, juvenile and adult stages of fishes in 30 sites from three HMWB. The construction scheme of the juvenile habitats comprised different degrees of embankment ranging from rip‐rap structures with steep bank angles to almost nature‐like construction schemes with very flat river‐banks and sparing usage of structural enrichment such as boulders and dead wood. In general, the differences between the three habitat types were more pronounced in density of different life stages than in the presence or absence of species or certain life stages. A steep bank angle and a high degree of engineering such as placement of rip‐rap embankment, boulders or dead wood structure in the habitats were hardly accepted by early larval and juvenile stages of rheophilic fishes. In contrast, the construction scheme of a nature‐like habitat with a flat bank angle (<10%), low water depth (mean = 24 cm) and a sparing usage of coarse woody debris (CWD) and boulders had the highest success. Other investigated habitat types did not provide additional benefit, neither in terms of supporting additional species and life stages, nor in high individual numbers and should thus only be implemented when land for restoration is scarce and nature‐like habitats cannot be realized. Copyright © 2016 John Wiley & Sons, Ltd.
Modeling injury severity of crashes involving golf carts: A case study of The Villages, Florida

Abstract Objective Crashes involving golf carts (GCs) have been on an increasing trend in recent years, particularly in the United States. This study focuses on analyzing GC crashes in the Florida community known as The Villages, one of the largest GC-oriented communities in the nation and worldwide. The objective was to evaluate the injury severity of crashes involving GCs in a retirement community where GCs are a common mode of transportation. Methods The ordinal logistic regression (OLR) and Decision Tree Ensemble (DTE) models were used to analyze the injury severity of 616 GC-related crashes. Models’ accuracy parameters were used to check their reliability. Results The analysis revealed that GC crash severity is influenced by various factors. Factors found to be significant by the OLR model in determining injury severity include ejection of one or more occupants from the GC, the extent of damage to the GC, GC speed prior to the crash, roadway characteristics (including divided roadways, traffic control devices, paved shoulders, and T-intersections), and roll-over incidents. The OLR model demonstrated an overall accuracy of approximately 71% in predicting injury severity. The DTE model performed better, with an overall accuracy of 78%. The OLR model’s findings were supported by the DTE model, which identified estimated GC speed, occupant(s) ejection from the GC, estimated GC vehicle damage, intersection type, and type of shoulder as the most important factors influencing GC crash severity. Conclusions Understanding these factors is vital for transportation agencies to develop effective strategies to reduce the severity of GC crashes, ensuring the safety of GC users. This study provides recommendations to transportation agencies on measures to improve the safety of GCs.
Temporal trends and transmission dynamics of pre-treatment HIV-1 drug resistance within and between risk groups in Kenya, 1986–2020

Abstract Background Evidence on the distribution of pre-treatment HIV-1 drug resistance (HIVDR) among risk groups is limited in Africa. We assessed the prevalence, trends and transmission dynamics of pre-treatment HIVDR within and between MSM, people who inject drugs (PWID), female sex workers (FSWs), heterosexuals (HETs) and perinatally infected children in Kenya. Methods HIV-1 partial pol sequences from antiretroviral-naive individuals collected from multiple sources between 1986 and 2020 were used. Pre-treatment reverse transcriptase inhibitor (RTI), PI and integrase inhibitor (INSTI) mutations were assessed using the Stanford HIVDR database. Phylogenetic methods were used to determine and date transmission clusters. Results Of 3567 sequences analysed, 550 (15.4%, 95% CI: 14.2–16.6) had at least one pre-treatment HIVDR mutation, which was most prevalent amongst children (41.3%), followed by PWID (31.0%), MSM (19.9%), FSWs (15.1%) and HETs (13.9%). Overall, pre-treatment HIVDR increased consistently, from 6.9% (before 2005) to 24.2% (2016–20). Among HETs, pre-treatment HIVDR increased from 6.6% (before 2005) to 20.2% (2011–15), but dropped to 6.5% (2016–20). Additionally, 32 clusters with shared pre-treatment HIVDR mutations were identified. The majority of clusters had R0 ≥ 1.0, indicating ongoing transmissions. The largest was a K103N cluster involving 16 MSM sequences sampled between 2010 and 2017, with an estimated time to the most recent common ancestor (tMRCA) of 2005 [95% higher posterior density (HPD), 2000–08], indicating propagation over 12 years. Conclusions Compared to HETs, children and key populations had higher levels of pre-treatment HIVDR. Introduction of INSTIs after 2017 may have abrogated the increase in pre-treatment RTI mutations, albeit in the HET population only. Taken together, our findings underscore the need for targeted efforts towards equitable access to ART for children and key populations in Kenya.
Gypenoside IX restores Akt/GSK-3β pathway and alleviates Alzheimer’s disease-like neuropathology and cognitive deficits

The main pathological changes of Alzheimer's disease (AD), a progressive neurodegenerative disorder, include senile plaque (deposited by amyloid beta), neurofibrillary tangle (formed by paired helical filaments composed of hyperphosphorylated tau), and massive loss of neurons. Currently there is a lack of ideal drugs to halt AD progression. Gypenosides (GPs), a kind of natural product, possesses potential therapeutic effects for neurodegenerative diseases, including AD. However, the specific role and mechanism of GPs for AD remain unclear. In the current study, we used staurosporine (STP), an inducer of apoptosis and causing tau hyperphosphorylation, to mimic AD models, and explored the role and mechanism of Gypenoside IX (one of the extracts of Gynostemma, GP for short name in our experiments) in STP treated primary hippocampal neurons and rats. We found STP not only increased apoptosis and tau hyperphosphorylation, but also significantly increased Aβ production, resulting in synaptic dysfunction and cognitive decline in mimic AD models by STP. GP was found to rescue apoptosis and cognitive impairments caused by STP treatment. Moreover, GP recovered the decreased synaptic proteins PSD95, Synaptophysin and GluR2, and blocked dendritic spine loss. Interestingly, GP decreased the STP induced tau hyperphosphorylation at different sites including S-199, S-202, T-205, T-231, S-262, S-396, and S-404, and at the same time decreased Aβ production through down-regulation of BACE1 and PS1. These effects in STP treated primary hippocampal neurons and rats were accompanied with a restoration of AKT/GSK-3β signaling axis with GP treatment, supporting that dysregulation of AKT/GSK-3β pathway might be involved in STP related AD pathogenesis. The results from our research proved that GP might be a potential candidate compound to reduce neuronal damage and prevent the cognitive decline in AD.
Enhancement of nerve regeneration through schwann cell-mediated healing in a 3D printed polyacrylonitrile conduit incorporating hydrogel and graphene quantum dots: a study on rat sciatic nerve injury model

Despite recent technological advancements, effective healing from sciatic nerve damage remains inadequate. Cell-based therapies offer a promising alternative to autograft restoration for peripheral nerve injuries, and 3D printing techniques can be used to manufacture conduits with controlled diameter and size. In this study, we investigated the potential of Wharton’s jelly-derived mesenchymal stem cells (WJMSCs) differentiated into schwann cells, using a polyacrylonitrile (PAN) conduit filled with fibrin hydrogel and graphene quantum dots (GQDs) to promote nerve regeneration in a rat sciatic nerve injury model. We investigated the potential of WJMSCs, extracted from the umbilical cord, to differentiate into schwann cells and promote nerve regeneration in a rat sciatic nerve injury model. WJMSCs were 3D cultured and differentiated into schwann cells within fibrin gel for two weeks. A 3 mm defect was created in the sciatic nerve of the rat model, which was then regenerated using a conduit/fibrin, conduit covered with schwann cells in fibrin/GQDs, GQDs in fibrin, and a control group without any treatment (n = 6/group). At 10 weeks after transplantation, motor and sensory functions and histological improvement were assessed. The WJMSCs were extracted, identified, and differentiated. The differentiated cells expressed typical schwann cell markers, S100 and P75. In vivo investigations established the durability and efficacy of the conduit to resist the pressures over two months of implantation. Histological measurements showed conduit efficiency, schwann cell infiltration, and association within the fibrin gel and lumen. Rats treated with the composite hydrogel-filled PAN conduit with GQDs showed significantly higher sensorial recovery than the other groups. Histological results showed that this group had significantly more axon numbers and remyelination than others. Our findings suggest that the conduit/schwann approach has the potential to improve nerve regeneration in peripheral nerve injuries, with future therapeutic implications.
Observation of tsunami‐generated ionospheric signatures over Hawaii caused by the 16 September 2015 Illapel earthquake

Tsunamis generate internal gravity waves (IGWs) that propagate vertically into the atmosphere and can create detectable signatures in the ionosphere. These signatures have consistently been observed in the presence of a tsunami for over a decade in the total electron content and for over 5 years in the 630.0 nm airglow. Here we show perturbations appearing in filtered GPS‐derived total electron content (TEC) and 630.0 nm airglow above Hawaii during the passing of the tsunami induced by the 16 September 2015 earthquake in Illapel, Chile. We report measurements of IGW parameters from both observation methodologies using a combination of prior methods and a newly developed method that uses a Gabor filter bank. A previously developed geometric model that takes into account the assumed posture of tsunami‐induced IGWs in the geomagnetic field and the observation geometry is shown to predict fairly well the expected location of the observation in the sky. Results of the Gabor filtering technique are also compared to previously published results for the 11 March 2011 Tohoku event. An overall comparison between all of the tsunami‐induced signatures that have appeared in both the 630.0 nm airglow and TEC above Hawaii to date is provided.
Quality of life in children with Down syndrome and its association with parent and child demographic characteristics: Parent‐reported measures

Abstract Background This study aims to explore the association between the quality of life (QoL) in children with Down syndrome (DS) and its relationship with demographic characteristics of both parents and children. The investigation encompasses five domains: physical and psychological well‐being, autonomy and parental relationship, social well‐being, and peers, as well as school and the learning environment. Method An online questionnaire, the KIDSCREEN‐27, was used to measure the QoL of 112 families with DS in Saudi Arabia, referred to as “Parent‐Reported Measures. ” Descriptive statistics were analyzed using the Statistical Package for Social Sciences. Results The study found that the QoL of children with DS showed high scores in the psychological well‐being, autonomy, parental relations, school, and learning environment domains. However, the physical and social well‐being and peer domains had lower scores, although still considered “good scores. ” Family income had a positively significant influence on all QoL domains. Specifically, higher family income was associated with better QoL outcomes, except for social well‐being. Parental age was found to influence psychological well‐being, while parental education and the relationship between the parent and child influenced social well‐being. Lastly, the child's gender was found to have an impact on the school and learning environment domain. Conclusion The study highlights the importance of understanding the impact of the demographic variability of children with DS and their parents on the QoL of their children. It emphasizes the need to address the needs of families with lower incomes and the importance of parental education and relationships with their children in improving social well‐being. The findings could aid policymakers and healthcare providers in improving the QoL for families with children who have DS.
Barriers and Enablers of Service Access and Utilization for Children and Adolescents With Attention Deficit Hyperactivity Disorder: A Systematic Review

Objective: To update a systematic review of the literature on the barriers and enablers of service access and utilization for children and adolescents with a diagnosis, or symptoms of attention deficit/hyperactivity disorder (ADHD), from the perspective of caregivers, clinicians, and teachers. Methods: Five databases were searched for peer-reviewed literature published from May 2012 to March 2023. Two independent reviewers completed a two-stage screening process and quality assessment. Results: Of 4,523 search results, 30 studies were included. Five main themes were generated: 1) Awareness of ADHD, 2) Stigma, 3) Parental choice and partnerships, 4) Education services as an integral component, 5) Referrals, waiting times, and logistics. More than half of the studies reported poor acknowledgement, expertise of ADHD, and stigma. Conclusion: Findings highlight the need for ongoing ADHD education for all involved and policy changes to service delivery systems to increase the availability of health providers with specialist ADHD expertise.
Impact of COVID-19 program adaptations on costs and cost-effectiveness of community management of acute malnutrition program in South Sudan

Abstract Objective: We assessed the impact of the COVID-19 pandemic and the protocol adaptations on cost and cost-effectiveness of community management of acute malnutrition (CMAM) program in South Sudan. Design: Retrospective program expenditure-based analysis of non-governmental organisation (NGO) CMAM programs for COVID-19 period (April 2020–December 2021) in respect to pre-COVID period (January 2019–March 2020). Setting: Study was conducted as part of a bigger evaluation study in South Sudan. Participants: International and national NGOs operating CMAM programs under the nutrition cluster participated in the study. Results: The average cost per child recovered from the programme declined by 20 % during COVID from $133 (range: $34–1174) pre-COVID to $107 (range: $20–333) during COVID. The cost per child recovered was negatively correlated with programme size (pre-COVID r-squared = 0·58; during COIVD r-squared = 0·50). Programmes with higher enrollment were cheaper compared with those with low enrolment. Salaries, ready to use food and community activities accounted for over two-thirds of the cost per recovery during both pre-COVID (69 %) and COVID (79 %) periods. While cost per child recovered decreased during COVID period, it did not negatively impact on the programme outcome. Enrolment increased by an average of 19·8 % and recovery rate by 4·6 % during COVID period. Conclusions: Costs reduced with no apparent negative implication on recovery rates after implementing the COVID CMAM protocol adaptations with a strong negative correlation between cost and programme size. This suggests that investing in capacity, screening and referral at existing CMAM sites to enable expansion of caseload maybe a preferable strategy to increasing the number of CMAM sites in South Sudan.
Visual Recognition of the Memento10k dataset: A P300 component ERP study

In modern and more specifically social media, most advertisements nowadays consist of very short, few second videos. This leads to an increase of interest in recognizability and rememberability of visual media. The present study analyzed event-related potentials (ERP’s) across 1000 trials of the Memento10k dataset to explore neurophysiological differences between videos that are later remembered or not when shown again to the same subject. The posterior brain region was analyzed across three channels and the right temporal cortex was analyzed in one channel. A significant difference, measured as p < . 05, in amplitude was found in the 340 – 408 ms window after onset between remembered and not remembered videos as well as around the 476 ms Timepoint across all trials, channels and participants in the visual cortex. In the right temporal cortex, a significant difference, measured as p <. 05, in amplitude was observed in the 306 – 816 ms window. These results suggest, in line with previous literature, that a stronger P300 component can be found for Remembered videos than Not Remembered videos in the right temporal lobe.In the visual cortex, an opposite effect was found, as a higher positivity was observed for Not Remembered videos.
Tellimagrandin-I and camptothin a exhibit chemopreventive effects in Salmonella enterica serovar Typhimurium strains and human lymphocytes

ABSTRACT Tellimagrandin-I (TL) and camptothin A (CA) are ellagitannins widely found in diverse plant species. Numerous studies demonstrated their significant biological activities, which include antitumor, antioxidant, and hepatoprotective properties. Despite this protective profile, the effects of TL and CA on DNA have not been comprehensively investigated. Thus, the aim of this study was to determine the mutagenic and antimutagenic effects attributed to TL and CA exposure on Salmonella enterica serovar Typhimurium strains using the Ames test. In addition, the cytotoxic and genotoxic effects were examined on human lymphocytes, employing both trypan blue exclusion and CometChip assay. The antigenotoxic effect was determined following TL and CA exposure in the presence of co-treatment with doxorubicin (DXR). Our results from the Ames test indicated that TL or CA did not display marked mutagenic activity. However, TL or CA demonstrated an ability to protect DNA against the damaging effects of the mutagens 4-nitroquinoline-1-oxide and sodium azide, thereby exhibiting antimutagenic properties. In relation to human lymphocytes, TL or CA did not induce significant cytotoxic or genotoxic actions on these cells. Further, these ellagitannins exhibited an ability to protect DNA from damage induced by DOX during co-treatment, indicating their potential beneficial usefulness as antigenotoxic agents. In conclusion, the protective effects of TL or CA against mutagens, coupled with their absence of genotoxic and cytotoxic effects on human lymphocytes, emphasize their potential therapeutic value in chemopreventive strategies.
Correlation of slow‐wave sleep with motor and nonmotor progression in Parkinson's disease

Abstract Objective This study aimed to explore the association between slow‐wave sleep and the progression of motor and nonmotor symptoms in patients with PD. Methods Data were collected from the Parkinson's Progression Markers Initiative study. Slow‐wave sleep, also known as deep non‐rapid eye movement (DNREM) sleep, was objectively assessed using the Verily Study Watch. Motor function was assessed using the Movement Disorder Society‐Unified Parkinson's Disease Rating Scale Part III score, Hoehn and Yahr stage, freezing of gait, motor fluctuations, and dyskinesia severity. Comprehensive assessments were conducted on nonmotor symptoms, including depression, anxiety, global cognitive function, and autonomic dysfunction. Statistical analyses involved repeated‐measures analysis of variance and linear regression. Results A total of 102 patients with PD were included in the study, with a median follow‐up duration of 3.4 years. In the long DNREM sleep duration group (n = 55), better motor function (DNREM × time interaction: F (1,100) = 4.866, p = 0.030), less severe sexual dysfunction (p = 0.026), and improved activities of daily living (p = 0.033) were observed at the last follow‐up visit compared with the short DNREM sleep duration group (n = 47). Reduced DNREM sleep duration is a risk factor for motor progression (β = −0.251, p = 0.021; 95% confidence interval = −0.465 to −0.038). Interpretation The findings suggest an association between longer DNREM sleep duration and slower motor and nonmotor progression in patients with PD.
Crystal structure solution for the A6B2O17 (A = Zr, Hf; B = Nb, Ta) superstructure

Zr6Ta2O17, Hf6Nb2O17 and Hf6Ta2O17 crystal structure solutions have been solved using synchrotron X-ray powder diffraction and neutron powder diffraction in conjunction with simulated annealing, charge flipping and Rietveld refinement. These structures have been shown to be isomorphous with the Zr6Nb2O17 superstructure, leading to the classification of the A6B2O17 (A = Zr, Hf; B = Nb, Ta) orthorhombic compound family with symmetry Ima2 (No. 46). The asymmetrical structural units of cation-centred oxygen polyhedra used to build the structure are as follows: (i) one set of symmetry-equivalent sixcoordinated polyhedra, (ii) three sets of symmetry-equivalent seven-coordinated polyhedra and (iii) one set of symmetry-equivalent eight-coordinated polyhedra. The potential for cation order and disorder was discussed in terms of cation atomic number contrast in X-ray and neutron powder diffraction as well as the bond valence method. In addition, the structural mechanisms for experimentally observed compositional variations within the solid solution range can be attributed to the addition or removal of a set of symmetryequivalent seven-coordinated polyhedra accompanied by corresponding oxygen tilts within the A6B2O17 structure.