Miracle-dz/UniFAR-FTUs huggingface dataset:
Modulatory Effect of Rutin on the Antitumor Activity and Genotoxicity of Cisplatin in Tumor-Bearing Mice

Purpose: Cisplatin is a cancer chemotherapeutic drug that has been extensively used in the treatment of a variety of cancers. However, the full usage of cisplatin is limited due to its treatment associated development of multiple side effects in the host. In the present study, the modulatory effect of rutin, a type of flavonoid, on the cisplatin mediated antitumor activity and allied genotoxicity in ascites Dalton’s lymphoma (DL)-bearing mice were investigated. Methods: The antitumor activity was determined by calculating the percent increase in the life span of mice, cell viability and scanning electron microscopy (SEM) of DL cells. Further, the modulatory effect of rutin on the cisplatin-induced genotoxic effects in the same DL-bearing mice was assessed by the analysis of micronuclei, chromosomal aberration and sperm abnormality. Results: The combination treatment of mice with rutin and cisplatin showed a considerable increase in the life span of the DL-bearing mice depicting better antitumor efficacy. SEM of these DL cells showed severe membrane deformities in DL cells such as fusion of cell membrane, membrane blebbing, cell shrinkage, membrane folding and loss in microvilli from the tumor cell surface which may lead to cell death. Cisplatin alone treatment caused an increase in the frequency of chromosomal aberrations, micronuclei and sperms abnormality. However, the combination treatment of DL-bearing mice with rutin and cisplatin comparatively reduced these genotoxic effects. Conclusion: The overall findings suggest that rutin enhances the cisplatin-mediated antitumor activity and cytotoxicity against DL cells and at the same time diminishes the genotoxic effects induced by cisplatin in the DL-bearing mice.
The Prediction of Fermentation Behavior by a Kinetic Model

A general kinetic model for the prediction of the fermentation behavior of grape juices is presented. The rates of sugar utilizaton, alcohol production, yeast population growth, and temperature change are predicted for wine fermentations with the Montrachet strain (#522 UCD) of Saccharomyces cerevisiae . Unknown quantities are estimated by fitting the solution of the model to the experimental data of Castor and Archer (5). Predictions are then presented which show the influence of initial conditions such as the sugar content, must temperature and yeast inoculum strength on the fermentation behavior.
International Journal of Applied Engineering Research

In recent years, aluminum-matrix composites (AMCs) have been widely used to replace cast iron in aerospace and automotive industries. Machining of these aluminum and EN31 requires better understanding of cutting processes regarding accuracy and efficiency. In this study, multiple regression analysis (MRA) and genetic algorithm (GE) were using to investigate the influence of parameters on the thrust force and torque in the drilling processes of hybrid composite materials. The models are identify by using cutting speed, feed, and volume fraction of the reinforcement particles as input data and the thrust force and torque as the output data. A comparison between two prediction methods is developing to compare the prediction accuracy. Here we are finding the spindle speed is insignificant or significant, it directing us to set it either at the highest spindle speed to obtain high material removal rate or at the lowest spindle speed to prolong the tool life depending on the need for the application.
THE ZOONOTIC IMPACT OF SWINE ERADICATION STRATEGY ON THE OCCURRENCE OF AVIAN INFLUENZA H5N1

This study was carried out to assess the impact of swine eradication strategy on the occurrence of Avian Influenza H5N1 in poultry backyards, poultry farms and human population, to identify risk factors for H5N1 around swine colonies in Egypt. The studied regions included three Governorates (Giza, Cairo and Qalyoubya). A total of 73 poultry backyard, 95 poultry farms and 168 human samples were examined for the presence of H5N1 before the eradication of swine. Moreover, a total of 67 poultry backyard, 85 poultry farms and 152 human samples were examined for the presence of H5N1 after the eradication of swine. All samples were examined by using real time PCR. The results revealed that 16 poultry backyards were positive before the eradication of swine while, 5 backyards were positive after applying this strategy. Also, 6 poultry farms were positive before applying the strategy and 3 farms were positive after the eradication of swine. In suspected humans; 22 and 9 cases were confirmed for the presence of H5N1 before and after the eradication of swine respectively. In conclusion, the applied swine eradication strategy had a significant impact on the control of H5N1 in backyard poultry, and human population. Conversely, there is no significant impact of the swine eradication on farm poultry.
A CORRELATION ANALYSIS OF LEARNING ORGANIZATION AND CHANGE MANAGEMENT: IS IT A STRATEGY TO HAVE A COMPETITIVE ADVANTAGE IN YOUR ORGANIZATION?

For an organization to be competitive, employee involvement plays a significant role. As human wants and needs are always changing, it necessitates new products and services in the market. When it comes to external triggers; social, political, economic, and technological changes impact organizational policies and processes. To update these elements, organizations must have a learning culture by adopting a strategic move in its structure. A mixed-approach (theories and survey/interview) study with an investigation on change management and learning organization in selected industrial companies in the UAE, with a sample size of 400, aids to find the relationship between learning organization, change management, and competitiveness. The quantitative and qualitative analysis confirms the significance level of related dependent variables and the acceptance of hypothesis tests. Hence, organizations can utilize the model, strategic learningchange bundle that is crafted from this study towards its competitive advantage. Moreover, this study can further be analyzed with other change management variables as change is a continuous process. PEOPLE: International Journal of Social Sciences ISSN 2454-5899
FACTORS INFLUENCING TURNOVER INTENTIONS AMONG EMPLOYEES OF A BANKING INSTITUTION

The study aims to identify the relationship between organizational commitment, organizational citizenship behavior, both at individuals (OCB-I) and organization level (OCB-O), organizational justice, perceived organizational support (POS), and turnover intention. The distribution of 200 questionnaires were carried out among employees of Bank ABC (headquartered in Kuala Lumpur), however only 123 usable responses were used. The findings revealed a significant negative association between all factors (organizational commitment, OCB, organizational justice, and POS) and turnover intention. Among the factors, the findings further discovered normative commitment as the most predictive factor influencing turnover intentions among employees of Bank ABC. This study provides useful insights for managers and HR practitioners in understanding the most significant factors that were more likely to reduce the employees’ intentions not to remain at their workplaces. By acknowledging the strongest predictor of intention to quit, this assisted in identifying employees who possessed such intent, so that the managers of Bank ABC can take remedial measures in order to retain them in the company.
Tracking geothermal anomalies along a crustal fault using (U − Th)∕He apatite thermochronology and rare-earth element (REE) analyses: the example of the Têt fault (Pyrenees, France)

Abstract. The Tet fault is a major crustal-scale fault in the eastern Pyrenees (France) along which 29 hot springs emerge, mainly within the footwall damage zone of the fault. In this study, ( U - Th ) / He apatite (AHe) thermochronology is used in combination with rare-earth element (REE) analyses in order to investigate the imprint of hydrothermal activity around two main hot spring clusters (Thues-les-Bains and St Thomas) and between them. The main goal is to better define the geometry and intensity of the recent thermal anomalies along the fault and to compare them with previous results from numerical modelling. This study displays 99 new AHe ages and 63 REE analyses on single apatite grains from samples collected in the hanging wall (18 to 43 Ma) and footwall (8 to 26 Ma) of the Tet fault. In the footwall, the results reveal AHe age resetting and apatite REE depletion due to hydrothermal circulation along the Tet fault damage zone, near the two hot spring clusters, and also in areas lacking present-day geothermal surface manifestation. These age resettings and element depletions are more pronounced around the Thues-les-Bains hot spring cluster and are spatially restricted to a limited volume of the damage zone. Outside this damage zone, new modelling of thermochronological data specifies the thermal evolution of the massifs. The footwall model suggests the succession of two main phases of cooling: between 30 and 24 Ma and a second one around 10 Ma. In the hanging wall, little evidence of hydrothermal imprint on AHe ages and REE signatures has been found, and thermal modelling records a single cooling phase at 35–30 Ma. Low-temperature thermochronology combined with REE analyses allows us to identify the spatial extent of a recent geothermal perturbation related to hydrothermal flow along a master fault zone in the eastern Pyrenees, opens new perspectives to constrain the geometry and intensity of geothermal fields, and provides new regional constraints on the cooling history of the footwall and hanging-wall massifs.
Effects of xipayi mouth rinse combined with minocycline on localized aggressive periodontitis' therapeutic effect and the levels of CRP, TNF-α, IL-6 in serum.

BACKGROUND Localized aggressive periodontitis is rare periodontitis in clinical practice, which often occurs in young adults under 35 years old, seriously affecting patients' quality of life. As a tetracycline antibacterial drug, minocycline is also considered an essential choice to treat periodontal disease. However, few reports focused on the effect of xipayi mouth rinse combined with minocycline on periodontal pathogens. The goal of this study was to investigate the clinical effect of xipayi mouth rinse combined with minocycline in the treatment of localized aggressive periodontitis and its effect on the levels of CRP, TNF-α, and IL-6. METHODS Ninety-six patients with limited aggressive periodontitis were selected and randomly divided into two groups. Forty-eight patients in the control group were treated with xipayi mouth rinse after primary periodontal treatment. Then, 48 patients in the experimental group were treated with xipayi mouth rinse combined with minocycline after primary periodontal treatment. The periodontal probe was applied to detect periodontal plaque index (PLI), periodontal pocket depth (PD), sulcus bleeding index (SBI), gingival index (GL), and clinical attachment loss (CAL) before and after treatment in both groups of patients. ELISA was used for detecting the expression levels of CRP, TNF-α, and IL-6 in the serum of patients in two groups before and after treatment. We compared the recurrence rates of the two groups after a 1-year follow-up. RESULTS Compared with the control group, the PLI, PD, SBI, GL, CAL, and total masticatory efficiency of the experimental group were significantly better than those of the control group. The levels of inflammatory factors CRP, TNF-α, and IL-6 were significantly declined, and the total effective rate of treatment was significantly elevated. After follow-up, it was found there was no noticeable difference in the recurrence rate between the two groups. CONCLUSIONS Xipayi mouth rinse, combined with minocycline in the treatment of localized aggressive periodontitis, can significantly improve the periodontal gingival condition and reduce the level of inflammatory factors. Also, the efficacy of the treatment was significant. This experiment has provided ideas for improving the clinical treatment of patients with localized aggressive periodontitis.
Intrinsic Dissipation Due to Mode Coupling in Two-Dimensional-Material Resonators Revealed Through a Multiscale Approach

While there has been tremendous progress in realizing high frequency, tunable, stable, atomically thin microresonators from individual two-dimensional (2D) materials and their combinations, their poor mechanical resonance quality at room temperature is still an open area of research. Taking a multiscale modeling approach and graphene as a representative 2D system, we show that intrinsic dissipation due to flexural mode coupling can explain the room temperature behavior. The inverse quality factor ${Q}^{\ensuremath{-}1}$, a nondimensional measure of dissipation, solely due to the coupling with nanometer wavelength flexural modes in the structure is found to be nonlinear in the vibration amplitude, and also dependent on the resonator size, strain, and temperature. At lower amplitudes and submicron to micron sizes, however, ${Q}^{\ensuremath{-}1}$ mediated by coupling with the submicro- to micrometer wavelength flexural modes dominates. This ${Q}^{\ensuremath{-}1}$ is amplitude independent, and bears a similar implicit dependence on the temperature ($T$) and inverse strain ($1/ϵ$), suggesting that $T/ϵ$ is a better metric to characterize the dissipation.
OVERVIEW OF GROWTH, ENERGY STATUS AND NUTRITIONAL MANAGEMENT OF WEANLING HORSES IN WINTER IN DIFFERENT HOUSING SYSTEMS

2 LÜHIKOKKUVÕTE . 3 LIST OF ABBREVIATIONS . 6 INTRODUCTION . 7 ACKNOWLEGMENTS . 7 1. REVIEW OF THE LITERATURE . 8 1.1. Estimated growth and aspects affecting the growth rate . 8 1.2. Calculations of digestible energy . 8 1.3. Feeding recommendations for foals . 10 1.4. Growth rate and nutritional management . 11 1.5. Effect of climate on energy intake and growth . 12 1.6. Effects of protein quality and limiting amino acids . 14 1.7. Different feeds and feeding ratios effecting the growth rate . 14 1.8. Influence of trace mineral concentrations to growth . 15 1.9. Quality aspects of forage . 16 1.10. Housing practices in Finland . 16 2. AIMS OF THE STUDY . 18 3. MATERIALS AND METHODS . 19 3.1. Characteristics of the foals . 19 3.1.2. Age . 19 3.2. Health assessment . 20 3.3. Body condition score . 20 3.4. Growth . 21 3.5. Overview of housing and management . 22 3.5. 1. Warm housing overview . 22 3.5. 2. Cold loose-housing overview . 22 3.5. 3. Feeding . 22 3.5. 4. Water . 23 3.6. Climate . 23
A Corpus- based Study of English Catenative Verbs among Native Speakers of English

The present study aims to examine the use of thirty catenative verbs as manifested in two corpora, namely, BNC and COCA in both the written and spoken sections which reflect the actual use of such constructions by native speakers of British and American English. Catenative verbs are categorized into three groups: group one that can be followed by either an infinitive or a gerund complement; group two is followed by an infinitive complement and group three is followed by a gerund complement. Native speakers face some difficulty in using group two and three verbs since they mix between the use of infinitives and gerunds. Results showed that the correct use of the catenative verbs of group two and three considerably outnumbered the incorrect use; thus results showed that some group two verbs were followed by gerund complements and some group three verbs were followed by infinitive complements.
EFFECT OF DIETARY CHROIUM AND ASCORBIC ACID ON PRODUCTIVE AND REPRODUCTIVE PERFORMANCE OF DOKKI4 CHICKENS UNDER WINTER CONDITIONS IN EGYPT

The effect of chromium (Cr) and ascorbic acid (AA) as a dietary supplementation on productive and reproductive performance of chickens was studied under winter conditions of Egypt. Total number of 300 (250 hens+50 cocks) Dokki4 chickens, of 30 weeks old were divided into 5 groups of 5 replicates each (10 hens +1 cock/ replicate). The remaining 25 cocks were divided into 5 groups of 5 cocks each and housed separately for semen evaluation. Birds in the 1 group (Cont.+) were kept in controlled normal temperature (CNT,25C) with 64±2% relative humidity (RH) and fed corn-soybean meal basal diet (16.4% crude protein, 2750 kcal ME/kg diet) without any supplementation. Birds in groups from 2 to 5 were exposed to natural low temperature (NLT, 8-18C) with 65±2%. These groups were fed either basal diet (Cont.-), or the basal diet supplemented either with either 250 ppm AA, 400 ppb Cr or 250 ppm AA plus 400 ppb Cr. Birds in NLT groups decreased (P≤0.05) relative body weight change (BWC, 8.6%), egg number (12.9%), egg mass (13.5%), laying rate (18.5%), hatchability of fertile eggs (4.6%), sperm motility (5.7%) and response to sheep red blood cells (SRBC's) post-injection at 6-days (13.6%) and at 9-days (25.8%), impaired feed conversion (28.9%) and economic efficiency (EE, 48.1%) and increased feed intake (9.3%), plasma contents of cholesterol (21.3%) and glucose (12.2%) contents and malondialdehyde (MDA) concentration in plasma (105.7%) and in semen (54.1%) compared with control group under CNT. Dietary supplementations alleviated (P≤0.05) the adverse effects of the NLT. Birds fed basal diet supplemented with AA+Cr under NLT had significantly (P≤0.05) improved BWC (5.9%), feed conversion (17.1%), egg number (9.5%), egg mass (5.3%), EE (33.6%), plasma cholesterol (10.9%) and glucose (10.2%), semen MDA (25.8%), response to SRBC's post-injection at 6-days (19.8%) and at 9-days (38.3%), sperm motility (6.2%) and hatchability of fertile eggs (5.2%) compared with control under NLT. There was no significant effect on most semen qualities, body temperature, fertility, hatchability (based on total eggs set) and hatched chick weight. It may be concluded that a dietary combination of 250 ppm of AA and 400 ppb of Cr provides positive effect on the productive and reproductive performance and EE of Dokki4 chickens under NLT.
Manejo de cocodrilos (Crocodylus acutus) en estanques de cultivo de tilapia en Cañas, Guanacaste

En la cuenca baja del Tempisque se han incrementado los avistamientos de cocodrilos ( Crocodylus acutus ) en cuerpos de agua naturales y artificiales. Este trabajo describe un plan implementado para operacionalizar el control de cocodrilos en estanques con cultivo de tilapia ( Oreochromis niloticus ). De acuerdo con el se redujo el consumo de producto por parte de cocodrilos y se potencio la seguridad de los trabajadores en esos estanques. Durante seis anos de actividad, el plan evoluciono desde la mera captura y posterior liberacion de animales en el punto mas lejano del rio Tempisque hasta el diseno y elaboracion de un plan de manejo para el control generalizado de cocodrilos en toda la region del gran humedal del Tempisque, apoyado en la realizacion de una investigacion formal sobre el estado de la poblacion de cocodrilos en la zona.
Is there a link between psychopathy and self-harm? a re- view of the literature

The aim of this review was to examine whether there is a link between psychopathy and selfharm. A systematic search identified 14 papers which examine this link. A quality appraisal checklist was used to evaluate the quality of each study. The application of the quality appraisal checklist showed that the majority of the studies had good internal validity; however, there were some biases that affected the external validity of some studies. The results indicated that there may be a positive association between total psychopathy score and self-harm; however, some studies with smaller sample sizes and low rates of selfharm failed to show this association. The results of most of the studies showed a positive association between Factor 2 of the Psychopathy Checklist (PCL-R; Hare, 2003) and selfharm. No link was found between Factor 1 and self-harm. The results did not show consistent evidence for a link between any of the four facets and self-harm. Although this review indicates a link between Factor 2 and selfharm, and a possible link between total psychopathy score and self-harm, the small number of studies in this area means that the research is not robust enough to provide strong evidence for these associations.
Patent Performance Measurement of the Medical Instruments Industry through Data Envelopment Analysis

This study analyzes 6,626 patents related to the medical instruments industry, and develops a subsequent patent analysis and performance assessment by means of DEA analysis. From the upper or lower ranking and comparing by DEA models this study found that the mix analysis could provide the results deeply with patents performance of DMUs in medical industries and worth to debate that would be difficult to see in traditional patent analysis. Finally, important elements that influence the performance of DMUs can also be found after sensitivity analysis. This study shows that less input may promote efficient performance while output is equal, but for traditional patent that would be different status with citation rate and R&D capacity. For medical industries’ top companies, they would be more considerate the different character of each correlative variable which have impact for three above input at least for comparison with the others by average efficient score.
Improving student’s mathematical problem solving skills through Quizizz

The Industrial Revolution 4.0 on Education in Indonesia affects school activities rapidly. Teachers are no longer educated in classrooms only, but they can also utilize technology to conduct distance learning. One interactive application that can be used as a form of question exercise is Quizizz. Therefore, this research aims to: first, examine the effectiveness of students' activities by using Quizizz on mathematical problem-solving skills; second, investigate the differences in the increase in students' ability to solve mathematical problems between the class with and without the Quizizz-aided learning method; third, describe the activities of students who used the Quizizz-aided drill learning method; and fourth, describe the students' responses in using Quizizz. The research was quasi-experiment with a pretest-posttest non-equivalent control group design. The participants in this study are 67 of Grade10 students divided into experimental and control classes. Data collection techniques used were tests for students' mathematical problem-solving skills and questionnaires. The instruments were validated using Pearson correlation, while the reliability was tested using Cronbach's Alpha. Then, the N-gain test was used to analyze the data. The results showed that there was an effect on students’ learning activities by using Quizizz on their problem-solving skills. Besides, there was a difference in the improvement of problem-solving skills between the class with and without Quizizz-aided. Furthermore, students’ activities in three meetings have increased. Moreover, students provided a positive response in learning using Quizizz. Thus, it can be concluded that Quizizz is effective in improving mathematical problem-solving skills.