Miracle-dz/UniFAR-FTUs huggingface dataset:
MicroRNA panels as diagnostic biomarkers for colorectal cancer: A systematic review and meta-analysis

Background Circulating microRNAs (miRNA) have emerged as promising diagnostic biomarkers for several diseases, including cancer. However, the diagnostic accuracy of miRNA panels in colorectal cancer (CRC) remains inconsistent and there is still lack of meta-analyses to determine whether miRNA panels can serve as robust biomarkers for CRC diagnosis. Methods This study performed a systematic review and meta-analysis to evaluate the clinical utility of miRNA panels as potential biomarkers for the diagnosis of CRC. The investigation systematically searched PubMed, Medline, Web of Science, Cochrane Library, and Google Scholar (21-year span, between 2000 and 2021) to retrieve articles reporting the diagnostic role of miRNA panels in detecting CRC. Diagnostic meta-analysis of miRNA panels used diverse evaluation indicators, including sensitivity, specificity, Positive Likelihood Ratio (PLR), Negative Likelihood Ratio (NLR), Diagnostic Odds Ratio (DOR), and the area under the curve (AUC) values. Results Among the 313 articles identified, 20 studies met the inclusion criteria. The pooled estimates of miRNA panels for the diagnosis of CRC were 0.85 (95% CI: 0.84–0.86), 0.79 (95% CI: 0.78–0.80), 4.06 (95% CI: 3.89–4.23), 0.20 (95% CI: 0.19–0.20), 22.50 (95% CI: 20.81–24.32) for sensitivity, specificity, PLR, NLR, and DOR, respectively. Moreover, the summary receiver operating characteristics (SROC) curve revealed an AUC value of 0.915 (95% CI: 0.914–0.916), suggesting an outstanding diagnostic accuracy for overall miRNA panels. Subgroup and meta-regression analyses demonstrated that miRNA panels have the highest diagnostic accuracy within serum samples, rather than in other sample-types – with a sensitivity, specificity, PLR, NLR, DOR, and AUC of 0.87, 0.86, 7.33, 0.13, 55.29, and 0.943, respectively. Sensitivity analysis revealed that DOR values did not differ markedly, which indicates that the meta-analysis had strong reliability. Furthermore, this study demonstrated no proof of publication bias for DOR values analyzed using Egger’s regression test (P > 0.05) and funnel plot. Interestingly, miR-15b, miR-21 and miR-31 presented the best diagnostic accuracy values for CRC with sensitivity, specificity, PLR, NLR, DOR, and AUC values of 0.95, 0.94, 17.19, 0.05, 324.81, and 0.948, respectively. Conclusion This study’s findings indicated that miRNA panels, particularly serum-derived miRNA panels, can serve as powerful and promising biomarkers for early CRC screening. Systematic review registration [www.crd. york.ac. uk/prospero], identifier [CRD42021268172].
Pre-existing mental health disorders and fear of COVID-19 pandemic: Data from a phone survey in community-dwelling older adults recruited in the NutBrain study

Background COVID-19 has caused a parallel epidemic of fear, anxiety, depression, stress, and frustration, particularly among the most fragile and vulnerable individuals, such as older people and those with previous mental health disorders. The present study aims to investigate the association between pre-existing mental health disorders, particularly depressive symptoms and Mild Cognitive Impairment (MCI), and the fear of COVID-19 and to explore which cognitive domains were involved in coping with fear in older people. Materials and methods In April 2020, we conducted a phone-interview questionnaire on community-dwelling older adults living in Lombardy Region (Italy) who participated in the NutBrain study. At baseline, socio-demographic characteristics along with lifestyles, and medical history were recorded. Participants underwent a neuropsychological battery exploring the global cognitive function and specific cognitive domains, to detect cases of MCI. The Center for Epidemiologic Studies Depression scale (CES-D) was used for screening depressive symptoms. During the phone survey, respondents were assessed using a structured questionnaire querying about fear of the COVID-19 pandemic. We performed multivariate logistic regression models to study the association between MCI and depressive symptomatology and fear. We also explored which cognitive domains were associated with fear. Odds Ratios (OR) with Confidence Intervals (95%CI) were estimated adjusting for potential confounders. Results Out of the 351 respondents (mean age 73.5 ± 6.1 years, 59.8% women, 49.1% high education), at baseline, 22.9% had MCI and 18.8% had depressive symptoms. In the multivariate analyses gender, age, and body mass index were significantly associated with the fear score. Considering different domains of fear, MCI was associated with fear of being infected themselves (OR 2.55, 95%CI 1.39–4.70) while depressive symptoms were associated with fear of contagion for family members (OR 2.38, 95%CI 1.25–4.52). Impaired executive cognitive function was positively associated with the highest tertile of the fear score (OR 3.28, 95%CI 1.37–7.74) and with fear of contagion for themselves (OR 3.39, 95%CI 1.61-7.17). Conclusion Older adults experienced different fear reactions, particularly when suffering from neurocognitive disorders and depressive symptoms; executive dysfunction was associated with increased fear. These results highlighted the need to pay attention to the psychological effects of the outbreak of COVID-19 to target intervention, especially among vulnerable subgroups of individuals. Clinical trial registration [ClinicalTrials.gov], identifier [NCT04461951].
Marked boundary rigidity for surfaces

We show that, on an oriented compact surface, two sufficiently $C^{2}$ -close Riemannian metrics with strictly convex boundary, no conjugate points, hyperbolic trapped set for their geodesic flows and the same marked boundary distance are isometric via a diffeomorphism that fixes the boundary. We also prove that the same conclusion holds on a compact surface for any two negatively curved Riemannian metrics with strictly convex boundary and the same marked boundary distance, extending a result of Croke and Otal.
Analytical description of the structure of chaos

We consider analytical formulae that describe the chaotic regions around the main periodic orbit ( x = y = 0 ) ? > of the Hénon map. Following our previous paper (Efthymiopoulos et al 2014 Celest. Mech. Dyn. Astron. 119 331) we introduce new variables ( &xgr; , &eegr; ) ? > in which the product &xgr; &eegr; = c ? > (constant) gives hyperbolic invariant curves. These hyperbolae are mapped by a canonical transformation Φ to the plane (x, y), giving ‘Moser invariant curves’. We find that the series Φ are convergent up to a maximum value of c = c max ? > . We give estimates of the errors due to the finite truncation of the series and discuss how these errors affect the applicability of analytical computations. For values of the basic parameter κ of the Hénon map smaller than a critical value, there is an island of stability, around a stable periodic orbit S, containing KAM invariant curves. The Moser curves for c ≤ 0.32 ? > are completely outside the last KAM curve around S, the curves with 0.32 < c < 0.41 ? > intersect the last KAM curve and the curves with 0.41 ≤ c < c max ≃ 0.49 ? > are completely inside the last KAM curve. All orbits in the chaotic region around the periodic orbit ( x = y = 0 ) ? > , although they seem random, belong to Moser invariant curves, which, therefore define a ‘structure of chaos’. Orbits starting close and outside the last KAM curve remain close to it for a stickiness time that is estimated analytically using the series Φ. We finally calculate the periodic orbits that accumulate close to the homoclinic points, i.e. the points of intersection of the asymptotic curves from x = y = 0 ? > , exploiting a method based on the self-intersections of the invariant Moser curves. We find that all the computed periodic orbits are generated from the stable orbit S for smaller values of the Hénon parameter κ, i.e. they are all regular periodic orbits.
Limiting eigenvalue distribution of random matrices of Ihara zeta function of long-range percolation graphs

We consider the ensemble of [Formula: see text] real random symmetric matrices [Formula: see text] obtained from the determinant form of the Ihara zeta function associated to random graphs [Formula: see text] of the long-range percolation radius model with the edge probability determined by a function [Formula: see text]. We show that the normalized eigenvalue counting function of [Formula: see text] weakly converges in average as [Formula: see text], [Formula: see text] to a unique measure that depends on the limiting average vertex degree of [Formula: see text] given by [Formula: see text]. This measure converges in the limit of infinite [Formula: see text] to a shift of the Wigner semi-circle distribution. We discuss relations of these results with the properties of the Ihara zeta function and weak versions of the graph theory Riemann Hypothesis.
A Floer homology invariant for $3$-orbifolds via bordered Floer theory

Using bordered Floer theory, we construct an invariant $\widehat{\mathit{HFO}}(Y^{\text{orb}})$ for $3$-orbifolds $Y^{\text{orb}}$ with singular set a knot that generalizes the hat flavor $\widehat{\mathit{HF}}(Y)$ of Heegaard Floer homology for closed $3$-manifolds $Y$. We show that for a large class of $3$-orbifolds, $\widehat{\mathit{HFO}}$ behaves like $\widehat{\mathit{HF}}$ in that $\widehat{\mathit{HFO}}$, together with a relative $\mathbb{Z}_2$-grading, categorifies the order of $H_1^{\text{orb}}$. When $Y^{\text{orb}}$ arises as Dehn surgery on an integer-framed knot in $S^3$, we use the $\{-1,0,1\}$-valued knot invariant $\varepsilon$ to determine the relationship between $\widehat{\mathit{HFO}}(Y^{\text{orb}})$ and $\widehat{\mathit{HF}}(Y)$ of the $3$-manifold $Y$ underlying $Y^{\text{orb}}$.
Recent of Investigations of Shock Wave Effects and Interactions Recent of Investigations of Shock Wave Effects and Interactions

Despite over fifty years of research on shock wave boundary layer effects and interactions, many related technical issues continue to be controversial and debated. The present survey provides an overview of the present state of knowledge such effects and interactions, including discussions of: (i) general features of shock wave interactions, (ii) test section configurations for investigation of shock wave boundary layer interactions, (iii) origins and sources of unsteadiness associated with the interaction region, (iv) interactions which included thermal transport and convective heat transfer, and (v) shock wave interaction control investigations. Of particular interest are origins and sources of low-frequency, large-scale shock wave unsteadiness, flow physics of shock wave boundary layer interactions, and overall structure of different types of interactions. Information is also provided in regard to shock wave investigations, where heat transfer and thermal transport were important. Also considered are investigations of shock wave interaction control strategies, which overall, indicate that no single shock wave control strategy is available, which may be successfully applied to different shock wave arrangements, over a wide range of Mach numbers. Overall, the survey highlights the need for additional understanding of fundamental transport mechanisms, as related to shock waves, which are applicable to turbomachinery, aerospace, and aeronautical academic disciplines. gas that of and I 00 in the downstream boundary layer prior to the events wave. Data for at 3 wave numerically showed a shift of high-energy, low-frequency to with a concomitant reduction of overall energy suction was applied within the of separated investigated the effects of steady and pulsed arc discharge arrangements, where the latter were employed at frequencies from 5 to 50 kHz, for control of an oblique shock wave, fonned using a compression ramp with an angle of 7 degrees relative to the wind tunnel test surface. The experimental study was undertaken using a supersonic wind tunnel with a maximum flow Mach number of 2.5. Results showed that the steady discharge arcs acted like a unifonnly distributed conductor. As the arc length was increased, the arc power increased, and the weakening effect on the was enhanced. Overall, the effect on was more with reduced by In contrast, reductions with pulsed were as large approximately 0.35
Configuration spaces of points, symmetric groups and polynomials of several variables

Denoting by $C_n(X)$ the configuration space of $n$ distinct points in $X$, with $X$ being either Euclidean $3$-space $\mathbb{E}^3$ or hyperbolic $3$-space $\mathbb{H}^3$ or $\mathbb{C}P^1$ , by $\mathscr{P}_{k,d}$ the vector space of homogeneous complex polynomials in the variables $z_0, \ldots, z_k$ of degree $d$, and by $\mathrm{Obs}^n_d$ the set of all $d$-subsets of $\{1,\ldots,n\}$, the symmetric group $\Sigma_n$ acts on $C_n(\mathbb{R}^3)$ by permuting the $n$ points and also acts in a natural way on $\mathrm{Obs}^n_d$. With $n = k+d$, the space $\mathscr{P}_{k,d}$ has dimension $\binom{n}{d}$, which is also the number of elements in $\mathrm{Obs}^n_d$. It is thus natural to ask the following question. Is there a family of continuous maps $f_I: C_n(X) \to \mathbb{P}\mathscr{P}_{k,d}$, for $I \in \mathrm{Obs}^n_d$ (here $\mathbb{P}$ is complex projectivization), which satisfies $f_I(\sigma.\mathbf{x}) = f_{\sigma.I}(\mathbf{x})$, for all $\sigma \in \Sigma_n$ and all $\mathbf{x} \in C_n(X)$, and such that, for each $\mathbf{x} \in C_n(X)$, the polynomials $f_I(\mathbf{x})$, for $I\in \mathrm{Obs}^n_d$, each defined up to a scalar factor, are linearly independent over $\mathbb{C}$? We provide two closely related smooth candidates for such maps for each of the two cases, Euclidean and hyperbolic, which would be solutions to the above problem provided a linear independence conjecture holds. Our maps are natural extensions of the Atiyah-Sutcliffe maps. Moreover, we get two constructions of actual solutions of the above problem for $X = \mathbb{C}P^1$, as we prove linear independence for these last two constructions. These last two constructions are classical in character, and can be viewed as higher dimensional versions of Lagrange polynomial interpolation. They appear to be new.
Multidimensional polynomial Euler products and infinitely divisible distributions on R^d

It is known to be difficult to find out whether a certain multivariable function to be a characteristic function when its corresponding measure is not tirivial to be or not to be a probability measure on R^d. Such results were not obtained for a long while. In this paper, multidimensional polynomial Euler product is defined as a generalization of the polynomial Euler product. By applying the Kronecker's approximation theorem, a necessary and sufficient condition for some polynomial Euler products to generate characteristic functions is given. Furthermore, by using the Baker's theorem, that of some multidimensional polynomial Euler products is also given. As one of the most important properties of probability distributions, the infinite divisibility of them is studied as well.
On the form factors of local operators in the lattice sine–Gordon model

We develop a method for computing form factors of local operators in the framework of Sklyanin’s separation of variables (SOV) approach to quantum integrable systems. For that purpose, we consider the sine–Gordon model on a finite lattice and in finite dimensional cyclic representations as our main example. We first build our two central tools for computing matrix elements of local operators, namely, a generic determinant formula for the scalar products of states in the SOV framework and the reconstruction of local fields in terms of the separate variables. The general form factors are then obtained as sums of determinants of finite dimensional matrices, their matrix elements being given as weighted sums running over the separate variables and involving the Baxter Q-operator eigenvalues.
Recommending Unanimously Preferred Items to Groups

Due to the pervasiveness of group activities in people’s daily life, group recommendation has attracted a massive research effort in both industry and academia. A fundamental challenge in group recommendation is how to aggregate the preferences of group members to select a set of items maximizing the overall satisfaction of the group; this is the focus of this paper. Specifically, we introduce a dual adjustment aggregation score, which measures the relevance of an item to a group. We then propose a recommendation scheme, termed 𝑘 -dual adjustment unanimous skyline, that seeks to retrieve the 𝑘 items with the highest score, while discarding items that are unanimously considered inappropriate. Furthermore, we design and develop algorithms for computing the 𝑘 -dual adjustment unanimous skyline efficiently. Finally, we demonstrate both the retrieval effectiveness and the efficiency of our approach through an extensive experimental evaluation on real datasets.
UvA-DARE (Digital Academic Social and cultural factors affecting uptake of interventions for malaria in pregnancy in Africa: a systematic review of the qualitative research

Background: Malaria during pregnancy (MiP) results in adverse birth outcomes and poor maternal health. MiP-related morbidity and mortality is most pronounced in sub-Saharan Africa, where recommended MiP interventions include intermittent preventive treatment, insecticide-treated bednets and appropriate case management. Besides their clinical efficacy, the effectiveness of these interventions depends on the attitudes and behaviours of pregnant women and the wider community, which are shaped by social and cultural factors. Although these factors have been studied largely using quantitative methods, qualitative research also offers important insights. This article provides a comprehensive overview of qualitative research on social and cultural factors relevant to uptake of MiP interventions in sub-Saharan Africa. Methods and Findings: A systematic search strategy was employed: literature searches were undertaken in several databases (OVID SP, IS Web of Knowledge, MiP Consortium library). MiP-related original research, on social/cultural factors relevant to MiP interventions, in Africa, with findings derived from qualitative methods was included. Non-English language articles were excluded. A meta-ethnographic approach was taken to analysing and synthesizing findings. Thirty-seven studies were identified. Fourteen concentrated on MiP. Others focused on malaria treatment and prevention, antenatal care (ANC), anaemia during pregnancy or reproductive loss. Themes identified included concepts of malaria and risk in pregnancy, attitudes towards interventions, structural factors affecting delivery and uptake, and perceptions of ANC. Conclusions: Although malaria risk is associated with pregnancy, women’s vulnerability is often considered less disease- specific and MiP interpreted in locally defined categories. Furthermore, local discourses and health workers’ ideas and comments influence concerns about MiP interventions. Understandings of ANC, health worker-client interactions, household decision-making, gender relations, cost and distance to health facilities affect pregnant women’s access to MiP interventions and lack of healthcare infrastructure limits provision of interventions. Further qualitative research is however required: many studies were principally descriptive and an in-depth comparative approach is recommended.
Delegation under Liquid Democracy Two Experiments.∗

Under Liquid Democracy (LD), decisions are taken by referendum, but voters are allowed to delegate their votes to other voters. Theory shows that in common interest problems where experts are correctly identified, the outcome can be superior to simple majority voting. However, delegation reduces the variety of independent information sources and can be advantageous only if used sparely. We report the results of two experiments, each studying two treatments: in one treatment, participants have the option of delegating to better informed individuals; in the second, participants can choose to abstain. The first experiment follows a tightly controlled design planned for the lab; the second is a perceptual task run online where information about signals’ precision is ambiguous. Although the experiments are very different, they reach the same result: in both, LD underperforms relative to both universal voting and abstention. In the lab experiment, we observe systematic overdelegation relative to the best theoretical equilibrium; in the perceptual task, we lack a precise theoretical benchmark, but delegation rates remain significantly higher than abstention rates. Faced with better informed experts, voters neglect the value of their own independent information. JEL codes: C92, D70, D72, D91
Hom-Lie-Rinehart algebras

ABSTRACT We introduce hom-Lie-Rinehart algebras as an algebraic analogue of hom-Lie algebroids, and systematically describe a cohomology complex by considering coefficient modules. We define the notion of extensions for hom-Lie-Rinehart algebras. In the sequel, we deduce a characterization of low dimensional cohomology spaces in terms of the group of automorphisms of certain abelian extension and the equivalence classes of those abelian extensions in the category of hom-Lie-Rinehart algebras, respectively. We also construct a canonical example of hom-Lie-Rinehart algebra associated to a given Poisson algebra and an automorphism.
X-RAY AND ROTATIONAL LUMINOSITY CORRELATION AND MAGNETIC HEATING OF RADIO PULSARS

Previous works have suggested a correlation between the X-ray luminosity and the rotational luminosity of radio pulsars. However, none of the obtained regression lines is statistically acceptable due to large scatter. We construct a statistical model that has an intrinsic – relation and reproduces the observed distribution about it by using a Monte Carlo simulator, which takes into account the effects obscuring the intrinsic relation, i.e., the anisotropy of radiation, additional heating, uncertainty in distance, and the detection limit of the instruments. From the ATNF pulsar catalog we collect 57 “ordinary radio pulsars” with significant detection and 42 with upper limits. The sample does not include high-magnetic-field pulsars (>1013 G), which are analyzed separately. We obtain a statistically acceptable relation with c1 = 1.03 ± 0.27 and L0 = 1035.38. The distribution about the obtained – relation is reproduced well by the simulator. Pulsars with abnormally high fall into two types: one is the soft gamma-ray pulsars, and the other is pulsars that are thermally bright in comparison with the standard cooling curve. On the other hand, pulsars showing low are found to have dim pulsar wind nebulae (PWNs). We argue that there is an unknown mechanism that governs both the magnetospheric emission and the PWNs, and it might involve the production rate of electron–positron pairs. High-field pulsars form a population that is distinct from ordinary pulsars due to their excess luminosities.
Geometric inequalities for manifolds with Ricci curvature in the Kato class

We obtain an Euclidean volume growth results for complete Riemannian manifolds satisfying a Euclidean Sobolev inequality and a spectral type condition on the Ricci curvature. We also obtain eigenvalue estimates, heat kernel estimates, Betti number estimates for closed manifolds whose Ricci curvature is controlled in the Kato class.