Miracle-dz/UniFAR-FTUs huggingface dataset:
Traumatic benign paroxysmal positional vertigo: personal experience and comparison with idiopathic BPPV

Abstract Objective Benign paroxysmal positional vertigo (BPPV) is the most common cause of vestibular vertigo, with post-traumatic origin in about 15% of cases. Management and prognosis of traumatic BPPV (T-BPPV) are still debated, especially about recurrence. The aim was to compare T-BPPV to idiopathic (I-BPPV). Design and study sample We analysed data about 795 BPPV patients: 716 idiopathic (90%) and 79 post-traumatic (10%), evaluating clinical history and bedside-examination, treating all patients with repositioning manoeuvres and reassessing them until the resolution of symptoms and nystagmus. Results Persistence rate in T-BPPV and I-BPPV patients was significantly different (p = 0.0074, OR = 2.31), respectively 12.6% and 5%. Also the rate of bilateral disease (p = 0.0063, OR = 4.72) and multicanalar involvement (p = 0.0183; OR = 4.67) were significantly higher in T-BPPV patients . There were no significant differences in age and sex distribution, side and canal interested. In T-BPPV group, the resolution rate with one manoeuvre was lower than I-BPPV (p = 0.0132: OR: 0,56). Recurrence rate was 38% in the T-BPPV group and 30.6% in the I-BPPV group, without significant difference. Conclusions T-BPPV resulted different from I-BPPV in the resolution rate, bilateral or multiple canal involvement and persistence rate. T-BPPV and I-BPPV does not differ for recurrence rate, suggesting that, after resolution, the natural course of post-traumatic and idiopathic BPPV is similar.
A Plasmodium cysteine protease required for efficient transition from the liver infection stage

The transitions between developmental stages are critical points in the Plasmodium life cycle. The development of Plasmodium in the livers of their mammalian hosts bridges malaria transmission and the onset of clinical symptoms elicited by red blood cell infection. The egress of Plasmodium parasites from the liver must be a carefully orchestrated process to ensure a successful switch to the blood stage of infection. Cysteine protease activity is known to be required for liver-stage Plasmodium egress, but the crucial cysteine protease(s) remained unidentified. Here, we characterize a member of the papain-like cysteine protease family, Plasmodium berghei serine repeat antigen 4 (PbSERA4), that is required for efficient initiation of blood-stage infection. Through the generation PbSERA4-specific antisera and the creation of transgenic parasites expressing fluorescently tagged protein, we show that PbSERA4 is expressed and proteolytically processed in the liver and blood stages of infection. Targeted disruption of PbSERA4 results in viable and virulent blood-stage parasites. However, upon transmission from mosquitoes to mice, Pbsera4(-) parasites displayed a reduced capacity to initiate a new round of asexual blood-stage replication. Our results from cultured cells indicate that this defect results from an inability of the PbSERA4-deficient parasites to egress efficiently from infected cells at the culmination of liver-stage development. Protection against infection with wildtype P. berghei could be generated in animals in which Pbsera4(-) parasites failed to establish infection. Our findings confirm that liver-stage merozoite release is an active process and demonstrate that this parasite-encoded cysteine protease contributes to parasite escape from the liver.
Urartian crop plant remains from Patnos (Aǧri), eastern Turkey

Abstract The analysis of eight samples of carbonised plant material from the Patnos area (Aǧri), an important site of the Urartian period in eastern Turkey is presented. Bread/macaroni wheat (Triticum aestivum L./T. durum Desf.) and domesticated emmer wheat (Triticum dicoccum Schübl.) are the main crop plants. Hulled barley (Hordeum L.) is less abundantly represented. Pulse seeds, bitter vetch (Vicia ervilia (L.) Willd. ), lentil (Lens culinaris Medik.) and Latyhrus L. -type were found in smaller numbers. A few wild seeds were also recorded. Özet Bu çalışmada, Türkiye'nin doǧusunda, Urartu Uygarlıǧı'nın önemli yerleşim yerlerinden biri olan Patnos yöresindeki (Aǧn) kazılarda alınan sekiz arkeobotanik örneǧin içindeki kömürleşmiş bitki kısımlarının analiz sonuçları verilmektedir. Analiz sonuçları, Urartular döneminde, Patnos bölgesinde ekmeklik/sert buǧdayın (Triticum aestivum L./T. durum Desf.) ve evcilleştirilmiş iki-sıralı buǧdayın (Triticum dicoccum Schübl.) temel tarla bitkileri olduǧunu göstermiştir. Kabuklu arpa (Hordeum L.) taneleri daha az miktardadır. Çok daha az miktarda bakliyata ait burçak (Vicia ervilia (L.) Willd. ), mercimek (Lens culinaris Medik.) ve mürdümük-tip (Latyhrus L.) tohumları bulunmuştur. Yine çok az miktarda yabani bitki meyveleri/tohumları kaydedilmiştir.
Venous hepatic segmentation in dogs (Canis lupus familiaris—L. 1758)

The external shape of the liver is varied and determines specific vascular arrangements. This morphological relationship is important to establish hepatic segmentation in different species submitted to surgeries that aim to preserve a larger area of liver parenchyma. After observing 60 livers injected with Neoprene Latex and three plastic moulds obtained by corrosion, eight hepatic venous segments were identified, drained by six hepatic veins agrouped into segmental veins, which drained one sector (segments I, VI, VII and VIII) and intersegmental veins, which drained more than one sector (segments II/III and IV/V). They were described as follows: left intersegmental vein, formed by a segmental vein from the papillary process (segment I), two to three lateral left segmental veins that drained the segment II, and one to five left paramedian segmental veins that drained the segment III; sagittal intersegmental vein, formed by the confluence between segmental vein of the quadrate lobe (segment IV) and the medial right paramedian segmental vein, which derived from the segment V; lateral right paramedian vein drained the dorsocranial sector of the segment VI; the lateral right segmental vein, formed by one to four vessels that drained segment VII, and the segmental vein of the caudate process, which drained the segment VIII. Understanding the number and disposition of the hepatic veins in lobate livers is essential to reduce bleeding risks in surgeries. The nomenclature based on segmentation analogy of non‐lobate liver could be less confusing and, therefore, be more useful in the surgical approaches of lobate livers.
Equimolar doses of hypertonic agents (saline or mannitol) in the treatment of intracranial hypertension after severe traumatic brain injury

Abstract Background: Mannitol and hypertonic saline (HTS) are effective in reducing intracranial pressure (ICP) after severe traumatic brain injury (TBI). However, their efficacy on the ICP has not been evaluated rigorously. Objective: To evaluate the efficacy of repeated bolus dosing of HTS and mannitol in similar osmotic burdens to treat intracranial hypertension (ICH) in patients with severe TBI. Methods: The authors used an alternating treatment protocol to evaluate the efficacy of HTS with that of mannitol given for ICH episodes in patients treated for severe TBI at their hospital during 2017 to 2019. Doses of similar osmotic burdens (20% mannitol, 2 ml/kg, or 10% HTS, 0.63 ml/kg, administered as a bolus via a central venous catheter, infused over 15 minutes) were given alternately to the individual patient with severe TBI during ICH episodes. The choice of osmotic agents for the treatment of the initial ICH episode was determined on a randomized basis; osmotic agents were alternated for every subsequent ICH episode in each individual patient. intracranial pressure (ICP), mean arterial pressure (MAP), and cerebral perfusion pressure (CPP) were continuously monitored between the beginning of each osmotherapy and the return of ICP to 20 mm Hg. The duration of the effect of ICP reduction (between the beginning of osmotherapy and the return of ICP to 20 mm Hg), the maximum reduction of ICP and its time was recorded after each dose. Serum sodium and plasma osmolality were measured before, 0.5 hours and 3 hours after each dose. Adverse effects such as central pontine myelinolysis (CPM), severe fluctuations of serum sodium and plasma osmolality were assessed to evaluate the safety of repeated dosing of HTS and mannitol. Results: Eighty three patients with severe TBI were assessed, including 437 ICH episodes, receiving 236 doses of HTS and 221 doses of mannitol totally. There was no significant difference between equimolar HTS and mannitol boluses on the magnitude of ICP reduction, the duration of effect, and the time to lowest ICP achieved (P > .05). The proportion of efficacious boluses was higher for HTS than for mannitol (P = .016), as was the increase in serum sodium (P = .038). The serum osmolality increased immediately after osmotherapy with a significant difference (P = .017). No cases of CPM were detected. Conclusion: Repeat bolus dosing of 10% HTS and 20% mannitol appears to be significantly and similarly effective for treating ICH in patients with severe TBI. The proportion of efficacious doses of HTS on ICP reduction may be higher than mannitol.
Telemedicine implementation in family medicine: Undergraduate clerkship during COVID‐19 pandemic

Introducing medical students to virtual visits with patients as an alternative to real-time patient contact during the COVID-19 crisis. Shortly before the onset of the pandemic, our organisation had prioritised the implementation of ‘virtual visits’ using a proprietary that allow the streaming of video, audio and clinical data, such as auscultation sounds, vital signs, fundoscopy, otoscopy, bedside ultrasound, and macrovideo of physical signs. These devices are commercially available and currently in clinical use. The data are shared in real time with students via teleconferencing software (Google Meet) allowing their participation in clinical care without risk of infection or need for PPE, providing an alternative method to gain clinical experience in a safe yet effective manner that consumes less resources critically needed for safe patient care, and in compliance with recommendations from regulatory authorities. The RCPS allows clinicians to care for patients in real time, allowing learners to remotely participate in the history-taking, physical examination interpretation, diagnosis and clinical decision making and providing valuable clinical experience and the opportunity to continue their training and learn more about patient care in biological disasters. The RCPS underwent alpha testing in different settings starting from simulated environments progressing towards the high-risk evaluation unit at the emergency room, allowing the prototype to be progressively modified. Learners were actively involved in the alpha testing providing valuable ideas for development though post-experiential focus groups.
Simvastatin in an experimental spinal cord injury model: a histopathological and biochemical evidence based study.

AIM In this study we tried to determine the possible neuroprotective effects of simvastatin in a rat model of Spinal Cord Injury (SCI) with the help of biochemical and histopathological tests. METHODS Rats were divided into 5 groups:1) SCI control, 2) Sham operated, 3) SCI with 10 mg/kg intraperitoneal simvastatin, 4) SCI with 10 mg/kg oral simvastatin, 5) SCI with 10 mg/kg subcutaneous simvastatin. After the treatment period, all rats were sacrificed; their blood and spinal cord samples were taken for biochemical and histopathological assessment. RESULTS When the groups were compared in terms of oedema and inflammation status, the scores of groups receiving simvastatin were better than the control and sham groups (p = 0.001 and p = 0.038 respectively). When the 3 treatment groups (oral, intraperitoneal and subcutaneous simvastatin groups) were compared with each other in terms of inflammation, haemorrhage and oedema, there were no significant differences between groups (p = 0.112, p = 0.797 and p = 0.188, respectively). NSE and S100B levels were significantly lower in the treatment groups compared to the sham group (p = 0.039 and p = 0.004 respectively). CONCLUSION According to our biochemical and histopathological findings, simvastatin 10 mg/kg has a positive impact in the spinal cord injury model in rats, regardless of route of application (Tab. 1, Fig. 5, Ref. 26).
Selective inhibition of arginase-2 in endothelial cells but not proximal tubules reduces renal fibrosis

Fibrosis is the final common pathway in the pathophysiology of most forms of chronic kidney disease (CKD). As treatment of renal fibrosis still remains largely supportive, a refined understanding of the cellular and molecular mechanisms of kidney fibrosis and the development of novel compounds are urgently needed. Whether arginases play a role in the development of fibrosis in CKD is unclear. We hypothesized that endothelial arginase-2 (Arg2) promotes the development of kidney fibrosis induced by unilateral ureteral obstruction (UUO). Arg2 expression and arginase activity significantly increased following renal fibrosis. Pharmacologic blockade or genetic deficiency of Arg2 conferred kidney protection following renal fibrosis, as reflected by a reduction in kidney interstitial fibrosis and fibrotic markers. Selective deletion of Arg2 in endothelial cells (Tie2Cre/Arg2fl/fl) reduced the level of fibrosis after UUO. In contrast, selective deletion of Arg2 specifically in proximal tubular cells (Ggt1Cre/Arg2fl/fl) failed to reduce renal fibrosis after UUO. Furthermore, arginase inhibition restored kidney nitric oxide (NO) levels, oxidative stress, and mitochondrial function following UUO. These findings indicate that endothelial Arg2 plays a major role in renal fibrosis via its action on NO and mitochondrial function. Blocking Arg2 activity or expression could be a novel therapeutic approach for prevention of CKD.
THE PARASITIZATION DYNAMICS OF TWO EGG PARASITES ON GYPSY MOTH

Two kinds of egg parasites Ooencyrtus kuwanae (Howard) and Anastatus japonicus Ashmead of gypsy moth Lymantria dispar, were studied in Beijing area from 1987 to 1988 O. kuwanae and A. japonicus has 4 - 5 and 2 - 3generations per year on gypsy moth eggs respectively. The parasitism varied with the dates of the egg masses collected, from 0.64-0.66% of A. japonicus in the eggs collected in late July to 2.26-4.18% in the eggs collected from middle July to middle August, for instance. The adult of these two egg parasites emerged in a two-year period. The emergence rate of O. kuwanae and A. japonicus were 99.35%, 81.0% and 0.7%, 19.0% in the current year and the next year respectively. For the purpose of the preservation of these two egg parasites,the best time to remove gypsy moth egg masses as a control measure is from late September in the current year to late March of the next year.
Control of the red fox in remnant forest habitats

Abstract Context. The European red fox (Vulpes vulpes) is subject to control by poison baiting in many parts of its range in Australia to protect both native and domestic species. Assessments of baiting programs can improve their effectiveness and help ensure that long-term control outcomes are achieved. Aims. We describe spatial and temporal patterns of bait uptake by the red fox in remnant forest within an agricultural matrix, including multiple bait-takes and hotspots of activity over time, and examine the response of foxes to baiting operations. Methods. We analysed bait uptake (Foxoff®) from 12 baiting operations over 5 years in the Goonoo forest, a 62 500 ha remnant surrounded by cleared land in central New South Wales, Australia. More than 8000 checks of bait-stations were analysed to provide indices of fox activity per bait-check, patterns of bait removal during bait-checks, and bait uptake at stations within and across operations. Fox activity was also assessed before and after four operations using sand plots. Key results. There was no consistent decline in relative fox activity in relation to changes in bait-take; increases in the activity index occurred in successive checks within most operations. Spatial analyses of checks within control operations showed that consecutive baits were removed at more than 70% of bait stations that were visited by foxes. Temporal analyses showed further that within an operation, multiple bait-takes occurred at ∼20% of stations and, across all operations, hot spots of activity could be identified. Conclusions. A short (2-week) baiting window in standard baiting operations may not be effective in reducing the activity of foxes across the landscape. It is likely that many baits are being cached during each operation, and that foxes move into the baited area from unbaited surrounding areas. Implications. More frequent and timely baiting operations are needed to achieve maximum disruption to the fox population in the remnant forest environment, at least as indicated by patterns of bait-take. Increasing the distance between baits, to ∼1.5 km, while reducing baiting-gaps at the landscape scale, will also be important to reduce caching and still ensure that baits are encountered.
Isolated Lung Perfusion in the Management of Acute Respiratory Distress Syndrome

Acute respiratory distress syndrome (ARDS) is associated with high morbidity and mortality, and current management has a dramatic impact on healthcare resource utilization. While our understanding of this disease has improved, the majority of treatment strategies remain supportive in nature and are associated with continued poor outcomes. There is a dramatic need for the development and breakthrough of new methods for the treatment of ARDS. Isolated machine lung perfusion is a promising surgical platform that has been associated with the rehabilitation of injured lungs and the induction of molecular and cellular changes in the lung, including upregulation of anti-inflammatory and regenerative pathways. Initially implemented in an ex vivo fashion to evaluate marginal donor lungs prior to transplantation, recent investigations of isolated lung perfusion have shifted in vivo and are focused on the management of ARDS. This review presents current tenants of ARDS management and isolated lung perfusion, with a focus on how ex vivo lung perfusion (EVLP) has paved the way for current investigations utilizing in vivo lung perfusion (IVLP) in the treatment of severe ARDS.
Antioxidant Profile of Pepper (Capsicum annuum L.) Fruits Containing Diverse Levels of Capsaicinoids

Capsicum is the genus where a number of species and varieties have pungent features due to the exclusive content of capsaicinoids such as capsaicin and dihydrocapsaicin. In this work, the main enzymatic and non-enzymatic systems in pepper fruits from four varieties with different pungent capacity have been investigated at two ripening stages. Thus, a sweet pepper variety (Melchor) from California-type fruits and three autochthonous Spanish varieties which have different pungency levels were used, including Piquillo, Padrón and Alegría riojana. The capsaicinoids contents were determined in the pericarp and placenta from fruits, showing that these phenyl-propanoids were mainly localized in placenta. The activity profiles of catalase, total and isoenzymatic superoxide dismutase (SOD), the enzymes of the ascorbate–glutathione cycle (AGC) and four NADP-dehydrogenases indicate that some interaction with capsaicinoid metabolism seems to occur. Among the results obtained on enzymatic antioxidants, the role of Fe-SOD and the glutathione reductase from the AGC is highlighted. Additionally, it was found that ascorbate and glutathione contents were higher in those pepper fruits which displayed the greater contents of capsaicinoids. Taken together, all these data indicate that antioxidants may contribute to preserve capsaicinoids metabolism to maintain their functionality in a framework where NADPH is perhaps playing an essential role.
Transcriptome analysis of the epididymis from Plag1 deficient mice suggests dysregulation of sperm maturation and extracellular matrix genes

The transcription factor pleomorphic adenoma gene 1 (PLAG1) is required for male fertility. Mice deficient in PLAG1 exhibit decreased sperm motility and abnormal epididymal tubule elongation and coiling, indicating impaired sperm maturation during epididymal transit. However, the downstream transcriptomic profile of the Plag1 knockout (KO; Plag1−/−) murine epididymis is currently unknown.
Brain 5‐HT1A Receptor Binding in Multiple System Atrophy: An [18F]‐MPPF PET Study

Loss of medullary serotonin (5‐hydroxytryptamine) neurons has been linked to respiratory disturbances in multiple system atrophy (MSA). Broader 5‐hydroxytryptamine dysfunction may contribute to additional motor/nonmotor symptoms in MSA. The objective of this study was to compare brain 5‐hydroxytryptamine1A receptor binding between MSA and healthy controls. Secondary objectives were to compare 5‐hydroxytryptamine1A receptor binding between MSA and Parkinson's disease (PD) and to assess potential associations with motor/nonmotor symptoms in MSA.
The Effect of Mixing Milk of Different Species on Chemical, Physicochemical, and Sensory Features of Cheeses: A Review

The yield and quality of cheese are associated with the composition, physicochemical, sensory, rheological, and microbiological properties of milk and with the technology applied to the milk before and/or during cheese processing. This review describes the most important research on cheeses obtained from processing mixtures of different milk species and discusses the effect of milk mixtures (i.e., species and mixture ratios) on composition, physicochemical, sensory, rheological, and microbiological properties of cheeses. More specifically, the present review paper will gather and focus only on studies that have provided a clear comparison between cheeses produced from a mixture of two milk species to cheeses produced from only one species.
Frailty Status Typologies in Spanish Older Population: Associations with Successful Aging

Background: Defining frailty typologies would contribute to guiding specific care interventions. These typologies could additionally be related to different health outcomes. This study aims at identifying subgroups of frail older adults based on the physical frailty phenotype and examining the relationships of these frailty profiles with quality of life and perceived health. Methods: This study relies on data from the SHARE project, namely a representative sample of 1765 Spanish-dwelling older adults identified as frail or pre-frail. Analysis included general descriptive statistics, exploratory latent class analysis (LCA) to determine the number of frailty subgroups, and LCA with covariates to examine differential relationships with markers of successful aging. Results: Statistical criteria and interpretability of the classes suggested that the LCA model with four classes should be retained. Class 1 was identified as the “frail people” group, Class 2 “activity problems” group, Class 3 “fatigued” group, and those belonging to Class 4 “lack of strength” group. Final LCA with covariates showed lower levels of quality of life and perceived health of the “frail” as compared to other frailty subgroups. Conclusion: This study revealed four different patterns of frailty attributes and further offered evidence on individuals’ differential status of health regarding distinct frailty conditions.