Miracle-dz/UniFAR-FTUs huggingface dataset:
Human Coronary Artery Endothelial Cell Response to Porphyromonas gingivalis W83 in a Collagen Three-Dimensional Culture Model

P. gingivalis has been reported to be an endothelial cell inflammatory response inducer that can lead to endothelial dysfunction processes related to atherosclerosis; however, these studies have been carried out in vitro in cell culture models on two-dimensional (2D) plastic surfaces that do not simulate the natural environment where pathology develops. This work aimed to evaluate the pro-inflammatory response of human coronary artery endothelial cells (HCAECs) to P. gingivalis in a 3D cell culture model compared with a 2D cell culture. HCAECs were cultured for 7 days on type I collagen matrices in both cultures and were stimulated at an MOI of 1 or 100 with live P. gingivalis W83 for 24 h. The expression of the genes COX-2, eNOS, and vWF and the levels of the pro-inflammatory cytokines thromboxane A2 (TXA-2) and prostaglandin I2 (PGI2) were evaluated. P. gingivalis W83 in the 2D cell culture increased IL-8 levels at MOI 100 and decreased MCP-1 levels at both MOI 100 and MOI 1. In contrast, the 3D cell culture induced an increased gene expression of COX-2 at both MOIs and reduced MCP-1 levels at MOI 100, whereas the gene expression of eNOS, vWF, and IL-8 and the levels of TXA2 and PGI2 showed no significant changes. These data suggest that in the collagen 3D culture model, P. gingivalis W83 induces a weak endothelial inflammatory response.
Evidence for a Strong Association of Short-Duration Intense Rainfall with Urbanization in the Beijing Urban Area

AbstractCorrelations of the urban heat island intensity (UHII) and key surface variables with the short-duration intense rainfall (SDIR) events are examined for the Beijing urban areas by applying hourly data of a high-density automatic weather station (AWS) network. Higher frequencies (amounts) of the SDIR events are found in or near the central urban area, and most of the SDIR events begin to appear in late evening and nighttime, but tend to end in late night and early morning. Correlations of the UHII with the SDIR frequency (amount) are all highly significant for more than 3 h ahead of the beginning of the SDIR events. Although the UHII at immediate hours (<3 h) before the SDIR occurrence is more indicative of SDIR events, their occurrence more depends on the magnitude of the UHII at earlier hours. The UHII before the beginning of the SDIR events also shows high-value centers in the central urban area, which is generally consistent with the distribution of the SDIR events. The spatial and temporal pat.
Employee Performance Model: Analysis of Training, Organizational Culture and Work Environment by Mediating Work Discipline

Purpose- This research provides a new strategy for stakeholders regarding factors influencing the improvement of employee performance through work discipline in the Indonesian Air Force.Design/Methodology- This is quantitative research. The research population consisted of all Indonesian Air Force employees. The sample size for this research was 400 employees. Data collection was survey with a questionnaire. This study utilized Smart PLS version 3.2. 9 and data analysis employed PLS-SEM.Findings- The findings indicate that organizational culture, work environment and work discipline significantly impact employee performance. Additionally, training, organizational culture, and work environment have an effect on work discipline and work discipline acts as a mediator in the relationship between training, organizational culture and work environment with employee performance.Practical Implications- The practical implications can assist the Indonesian Air Force in enhancing employee performance and creating a better work environment. Through appropriate actions, the organization can achieve improved outcomes in pursuing its objectives.
A Predictive Assessment of Ochratoxin A’s Effects on Oxidative Stress Parameters and the Fermentation Ability of Yeasts Using Neural Networks

The aim of this paper was to examine the effect of different OTA concentrations on the parameters of oxidative stress (glutathione (GSH) and malondialdehyde (MDA) concentrations) and glucose utilization in ethanol production by wine yeasts. In addition to the above, artificial neural networks (ANN) were used to predict the effects of different OTA concentrations on the fermentation ability of yeasts and oxidative stress parameters. The obtained results indicate a negative influence of OTA (4 µg mL−1) on ethanol production after 12 h. For example, K. marxianus produced 1.320 mg mL−1 of ethanol, while in the control sample 1.603 µg mL−1 of ethanol was detected. However, after 24 h, OTA had no negative effect on ethanol production, since it was higher (7.490 and 3.845 mg mL−1) in comparison to control samples. Even low concentrations of OTA affect GSH concentrations, with the highest being detected after 12 and 24 h (up to 16.54 µM), while MDA concentrations are affected by higher OTA concentrations, with the highest being detected at 24 h (1.19 µM). The obtained results with the use of ANNs showed their potential for quantification purposes based on experimental data, while the results of ANN prediction models have shown to be useful for predictions of what outcomes different concentrations of OTA that were not part of experiment will have on the fermentation capacity and oxidative stress parameters of yeasts.
Absorbance enhancement of a treated Tanzanian kaolin for removal of synthetic dyes from contaminated water

Kaolin possesses unique features suitable for removing pollutants from aqueous solutions, in this regard, improving its effectiveness as an adsorbent is important. This study focused on refining the absorbance efficiency of Pugu kaolin clay from Tanzania to enhance its utilization in removing textile dyes from contaminated water. The process involved acid-activation after calcination at 750oC. Characterization using X-ray Fluorescence (XRF), X-ray diffraction (XRD), Attenuated Total Reflectance-Fourier Transform Infrared Spectroscopy (ATR-FTIR) and Porosimeter techniques revealed the presence of kaolinite [Al2Si2O5(OH)4], silica (SiO2) and microcline [KAlSi3O8] as the main phases. Acid treatment resulted in an increase in silica content from 44.18% to 58.81% due to the appearance of tridymite, while alumina decreased from 26.70% to 12.74% due to the removal of kaolinite. Surface area significantly expanded from 15.36 to 149.61 m2/g as acid-soluble impurities were eliminated. Chemical composition was also altered, with a decrease in Fe2O3 and increase in other major oxides. The impact of acid activation on the adsorption capacity of the clay was investigated by studying various parameters such as contact time, temperature, adsorbent dose, initial pH and adsorbate concentration. Basic Blue 9 (BB9) and Direct Red 28 (DR28) dyes were used as model adsorbates. The results obtained at optimal conditions of 3 hours contact time, 27oC temperature, 0.9 g adsorbent dose, initial pH of 11 and initial adsorbate concentration of 90 mg/L, showed that acid modification of the clay increased its capacity to adsorb BB9 from 96.82% to 99.91%, and DR28 from 86.33% to 95.04%. These findings underscore the positive impact of modifying the raw clay, enhancing its suitability for dye removal applications.
The effect of the four pharmacological pillars of heart failure on haemoglobin level

Anaemia, a condition characterized by low levels of haemoglobin, is frequently observed in patients with heart failure (HF). Guideline-directed medical therapy improves HF outcomes by using medications like beta blockers, angiotensin-converting enzyme inhibitors, and angiotensin receptor blockers, along with mineralocorticoid receptor antagonists and sodium-glucose cotransporter 2 inhibitors. In this study, we aimed to review the pathophysiology of anaemia in patients with HF and present the current evidence regarding the relationship between the main recommended medications for these patients and haemoglobin levels. The authors conducted a comprehensive search in the medical literature for relevant original clinical articles in which the four pharmacological pillars of HF were given to the patients; we, then, assessed whether the association of use of these medications and haemoglobin level or development of anaemia was provided. These common medications have been shown in the literature that may exacerbate or ameliorate anaemia. Besides, it has been shown that even in the case that they result in the development of anaemia, their use is associated with positive effects that outweigh this potential harm. The literature also suggests that among patients receiving medications with negative effects on the level of haemoglobin, there was no difference in the rate of mortality between anaemic and non-anaemic patients when both were on treatment for anaemia; this point highlights the importance of the detection and treatment of anaemia in these patients. Further research is needed to explore these relationships and identify additional strategies to mitigate the risk of anaemia in this population.
The Impact of Total Tumor Diameter on Lymph Node Metastasis and Tumor Recurrence in Papillary Thyroid Carcinomas

(1) Introduction: The impact of multifocality/bilaterality on the prognosis of papillary thyroid carcinoma (PTC) is a matter of debate. In order to clarify this debate, several studies have attempted to identify additional parameters associated with poor prognosis, including total tumor diameter (TTD), in the context of multifocal PTCs. In this context, this study was carried out to investigate the impact of TTD on tumor recurrence and lymph node metastasis (LNM) in PTCs. (2) Materials and Methods: The sample of this single-center retrospective study consisted of 706 patients diagnosed with PTC. TTD was calculated as the sum of the largest diameters of tumor foci in multifocal tumors. The resulting TTDs were grouped into TTDs ≤ 10 mm, TTDs > 10 mm, TTDs ≤ 20 mm, and TTDs > 20 mm, using 10 mm and 20 mm as cutoff values. (3) Results: There was no significant difference between multifocal papillary microcarcinomas (PTMCs) with a TTD of >10 mm and unifocal PTCs with a primary tumor diameter (PTD) of >10 mm except for advanced age and lymphovascular invasion (LVI). In addition, perineural invasion (PNI) and TTD > 10 mm were found to be significant risk factors for LNM, and PNI, TTD > 10 mm, TTD > 20 mm, and bilaterality were found to be significant risk factors for recurrence. LVI, and TTD > 10 mm were found to be independent significant predictors for recurrence, and LVI and extrathyroidal extension (ETE) were found to be independent significant predictors for LNM. (4) Conclusions: Considering TTD > 10 mm in recurrence risk categorization models and adopting a clinical approach that takes into account multifocal PTMCs with TTD > 10 mm along with unifocal PTCs with PTD > 10 mm may be more useful in terms of clinical management of the disease.
Abundances of Cavity-nesting Birds and their Dead Wood Resources in Closed-canopy Managed and Unmanaged Mixedwood Forests of Boreal Northeastern Ontario

In eastern boreal forests harvesting has displaced forest fires as the dominant disturbance, changing the natural age mosaic and reducing old-growth forest and standing dead wood supplies. Herein, eleven cavity nesting bird species and their habitats are compared among three stand histories (mid-rotation and mature regenerated stands (31-40 and 47-64 years post-harvest, respectively) and uncut forest (80+ years old)) surveyed in boreal mixedwood sites in northeastern Ontario. Yellow-bellied sapsucker, northern flicker and red-breasted nuthatch abundances were greater in uncut sites. While large live tree density and basal area increased with time since disturbance, a U-shaped pattern in large dead stem density was observed with old-cut sites having low supplies. Resource use based on breeding and feeding evidence was examined relative to availability and large dead trembling aspen was found to be important. Results indicate a diminished ability of post-harvest stands to supply similar habitat attributes to those of uncut forest.
Recent Achievements in the Development of Biomaterials Improved with Platelet Concentrates for Soft and Hard Tissue Engineering Applications

Platelet concentrates such as platelet-rich plasma, platelet-rich fibrin or concentrated growth factors are cost-effective autologous preparations containing various growth factors, including platelet-derived growth factor, transforming growth factor β, insulin-like growth factor 1 and vascular endothelial growth factor. For this reason, they are often used in regenerative medicine to treat wounds, nerve damage as well as cartilage and bone defects. Unfortunately, after administration, these preparations release growth factors very quickly, which lose their activity rapidly. As a consequence, this results in the need to repeat the therapy, which is associated with additional pain and discomfort for the patient. Recent research shows that combining platelet concentrates with biomaterials overcomes this problem because growth factors are released in a more sustainable manner. Moreover, this concept fits into the latest trends in tissue engineering, which include biomaterials, bioactive factors and cells. Therefore, this review presents the latest literature reports on the properties of biomaterials enriched with platelet concentrates for applications in skin, nerve, cartilage and bone tissue engineering.
Reexamination of the Wave Activity Envelope Convective Scheme in Theoretical Modeling of MJO

AbstractThe skeleton model is one of the theoretical models for understanding the essence of the Madden–Julian oscillation (MJO). The heating parameterization scheme in the skeleton model assumes that precipitation tendency is in phase and proportional to the low-level moisture anomaly. The authors show that the observed MJO precipitation tendency is not in phase with the low-level moisture anomaly. The consequence of the wave activity envelope (WAE) scheme is reexamined by using a general MJO theoretical framework in which trio-interaction among convective heating, moisture, and wave–boundary layer (BL) dynamics are included and various simplified convective schemes can be accommodated. Without the BL dynamics, the general model framework can be reduced to the original skeleton model. The authors show that the original skeleton model yields a neutral mode that exhibits a “quadrupole” horizontal structure and a quadrature relationship between precipitation and low-level moisture; both are inconsistent wit.
Interplay of Investor Cognition, Financial Literacy, and Neuroplasticity in Investment Decision Making: A Study of Nepalese Investors

The study examines how investor cognition and financial literacy impact neuroplasticity among Nepalese investors in stock market by assessing the mediating effect of risk absorption capacity in relation to investor cognition, financial literacy and neuroplasticity in investors. The cross-sectional data was purposefully collected from 389 respondents ranging from under 25 years to older residing in the Kathmandu valley and had previously invested in market and incurred losses. Primary data was analysed quantitatively by using SMARTPLS. The study findings indicated significant impacts of the constructs - investors’ cognition, financial literacy, and risk absorption, on investors’ neuroplasticity. Additionally, the structural model affirms that risk absorption acts as a mediator in the relationship between investors’ cognition, financial literacy, and neuroplasticity. By filling in empirical gaps and utilising social cognitive theory, this study advances our knowledge of how investor cognition, financial literacy, risk absorption capacity, and neuroplasticity impacts financial decisions, especially in developing countries like Nepal. Thus, this study stresses the eminent role of cognitive processes and financial literacy in decision-making, with the potential to assist policy formulation for equity-related financial product marketers and aid in tackling psychological trauma and reluctance among prospective investors in stock markets due to past losses.
Current Status and Countermeasures of Health Surveillance for the Elderly --Based on the Status of Aging in China

By 2024, more than 20% of China's population will be beyond the age of 60 due to rising life expectancy and the implementation of the one-child policy. Leading China to face substantial challenges in providing health surveillance for its rapidly aging population. The national health literacy level of China is 27.78% in 2022, the elderly population deserve a lower level due to low education level. Resources between rural and urban has a huge gap. The majority of primary care facilities are unable to handle the chronic illnesse`1s that affect senior individuals. Lifestyle has changed along the financial arise, chronic illness categories are changing. Addressing risk factors for contemporary diseases like diabetes requires a shift in the healthcare system. In addition, declining family sizes are restricting the availability of traditional familial care. Community services have grown, but their quality and coverage are still inconsistent, particularly in rural areas. Coordinated efforts are required to increase health literacy. Fairly distribute medical resources and experts, direct illness preventive initiatives, and create comprehensive community-based care models in order to improve health surveillance for China's elderly population. Resource imbalance can be addressed with targeted investments in geriatric training programs, primary care, and digital health technologies.
How Do Care Partners of People with Rare Dementia Use Language in Online Peer Support Groups? A Quantitative Text Analysis Study

We used quantitative text analysis to examine conversations in a series of online support groups attended by care partners of people living with rare dementias (PLWRD). We used transcripts of 14 sessions (>100,000 words) to explore patterns of communication in trained facilitators’ (n = 2) and participants’ (n = 11) speech and to investigate the impact of session agenda on language use. We investigated the features of their communication via Poisson regression and a clustering algorithm. We also compared their speech with a natural speech corpus. We found that differences to natural speech emerged, notably in emotional tone (d = −3.2, p < 0.001) and cognitive processes (d = 2.8, p < 0.001). We observed further differences between facilitators and participants and between sessions based on agenda. The clustering algorithm categorised participants’ contributions into three groups: sharing experience, self-reflection, and group processes. We discuss the findings in the context of Social Comparison Theory. We argue that dedicated online spaces have a positive impact on care partners in combatting isolation and stress via affiliation with peers. We then discuss the linguistic mechanisms by which social support was experienced in the group. The present paper has implications for any services seeking insight into how peer support is designed, delivered, and experienced by participants.
THE FOSSIL RABBIT FROM VALDEMINO CAVE (BORGIO VEREZZI, SA VONA) IN THE CONTEXT OF WESTERN EUROPE ORYCTOLAGINI OF QUATERNARY

The present research deals with the remains of a lagomorph found at Valdemino cave and comes to the conclusion that it is a rabbit with peculiar characteristics in comparison with the other known species Oryctolagus laynensis, O. lacosti and O. cuniculus. We studied other fossil remains of rabbit populations from Villafranchian and middle Pleistocene deposits and compared them with data from the literature and with recent material. The analysis leads us to maintain two phylogenetic hypotheses about the history of Oryctolagini. The first one, already formulated by Lopez Martinez, suggests that O. cuniculus derives from O. laynensis, while the origin of O. lacosti is unknown; according to the second hypothesis O. laynensis would be the common ancestor of two phyletic lineages, O. lacosti and O. cuniculus. In both cases the lagomorph from Valdemino would be the form derived from O. lacosti, from which however it differs in peculiar characteristics. Since the rabbit from Valdemino survives until the beginning of Postgalerian, its disappearance may coincide with the retreat of O. cuniculus from western Europe in Spain and, perhaps, in south-western France, before the last glaciation. O. cuniculus survived in Spain, from where it spread once again over western Europe as a result of man.
Revascularization of Non-Vital, Immature, Permanent Teeth with Two Bioceramic Cements: A Randomized Controlled Trial

The aim of this study was to clinically and radiographically assess the effects of two bioceramic cements as coronal plug materials for the revascularization of non-vital, immature, permanent teeth with apical periodontitis. Twenty non-vital, immature, permanent, anterior teeth with apical periodontitis were included in this study. Samples were randomly divided into two groups based on the coronal plug materials used; group I (GI): Well Root PT (Vericom, Gangwon-do, Korea) and group II (GII): MTA Biorep (Itena Clinical, Paris, France) (n = 10). Follow-up was conducted clinically and radiographically for up to 12 months to evaluate the changes in root dimensions and resolution of the periapical disease and investigate the degree of success. Data were statistically analyzed using ANOVA tests and Mann–Whitney U tests at a 0.05 significance level. At 12 months, none of the patients in either test group had clinical signs/symptoms. There was a slight increase in root length (4.4% in GI and 3.4% in GII) and a slight increase in dentin wall thickness (10.2% in GI and 9.9% in GII) with no statistically significant (p > 0.05) differences. Whilst there was a significant decrease in lesion dimension in all patients after 12 moths of treatment (93% in GI and 91% in GII), there were no statistically significant differences between the two study groups (p > 0.05). Regarding the degree of success, all cases (100%) achieved the primary goal (the elimination of symptoms and the evidence of bony healing), while 60% in GI and 40% in GII achieved the secondary goal (increased root wall thickness and/or increased root length). No statistically significant difference was found between groups (p > 0.05). Both bioceramic cements showed satisfactory clinical and radiographic findings. Premixed calcium aluminosilicate and tricalcium silicate cements could be used as coronal plug materials in revascularization procedures. Bioceramic cements can be considered promising coronal plug materials for the revascularization of immature, permanent teeth with necrotic pulps and apical periodontitis due to their physicochemical and biological properties.
A Lunar Terrain Auto Recognition Algorithm with Adaptive Threshold by Gushing and Immersion

As we know, the recognition of lunar terrain is the beginning of the lunar research. Therefore, an accurate and effective automatic recognition of lunar terrain is an integral part of lunar research. This paper has proposed an improved recognition algorithm for lunar terrain based on gushing and immersion. First of all, we identifying the lunar mare area and the highland area with four features used in k-means clustering on CCD image and DEM data. Next, the boundary of lunar mare and lunar highland will be extracted and calculate the average height on DEM image which had match to the CCD image. Then, we use the average value of boundary area as the threshold of gushing algorithm. Finally, the gushing and immersion algorithm will start at the minimal value of lunar mare area. The result will show the classification of lunar terrain. For the testing, the SI and Crisium had been chosen as two typical areas of lunar terrain. This improved algorithm can distinguish the lunar mare and highland automatically. The algorithm shows a better accuracy than other relevant algorithm.