Miracle-dz/UniFAR-FTUs huggingface dataset:
Perception of roles across the interprofessional team for delivery of medical assistance in dying

ABSTRACT In 2016, Canada joined many jurisdictions worldwide in legalizing Medical Assistance in Dying (MAiD). Given the paucity of qualitative research regarding the involvement of interprofessional health care providers (HCPs) in MAiD, the goal of this study was to better understand how HCPs viewed their role(s). Semi-structured interviews were conducted with 3 pharmacists, 10 nurses, and 8 social workers at an academic hospital in Toronto. Thematic analysis generated six broad themes: 1) Practical/Technical Component, 2) Education, 3) Support, 4) “Part of the Job,” 5) “All of the Job,” and 6) Lack of Published Information. While nurses and social workers espoused many commonalities, nursing roles were more “in the moment,” whereas social workers viewed their roles as beginning earlier and extending after provision of MAiD. There was a spectrum of how participants perceived their role: pharmacists minimized the task of dispensing medications as an insignificant experience, nurses viewed involvement as consistent with their other professional duties (specifically non-MAiD deaths), and social workers described MAiD as a unique opportunity to employ the full gamut of their skills. The study highlights the importance of supporting HCPs through education and information at both regulatory and research levels, recognizing the key roles they play in MAiD.
The Experience of Living with Severe Asthma, Depression and Anxiety: A Qualitative Art-Based Study

Purpose Severe asthma, depression and anxiety often co-exist and increase disease burden. Currently there are no published studies investigating severe asthma and psychological comorbidity using arts-based methodology. We aimed to (i) illustrate the individual experience of adults living with severe asthma, with and without symptoms of depression and/or anxiety and (ii) to explore common characteristics depicted in artworks between those groups. Patients and Methods A qualitative arts-based study was conducted. Adults with severe asthma were categorised into two groups according to Hospital Anxiety and Depression Scale scores (<8 on either subscale [SA-D/A] (N=15) or (≥8 on one or both subscales [SA+D/A] (N=15). Art thematic analysis was undertaken using a hybrid approach. The Common-Sense Model of Self-Regulation was used to examine frequencies in artworks. Results Participants with severe asthma alone and severe asthma with depression/anxiety were of older age (median 67 and 63 years respectively). There was greater asthma QoL impairment in participants with psychological comorbidity than without (4.7 ± 8.3 versus 5.8 ± 0.85, p=<0.01). Analysis of art works identified three themes: (1) “darkness” depicting misery, isolation and sadness; (2) “impacts” describing physical and social consequences; and (3) “resilience” illustrating acceptance and perseverance of living with all three conditions. Conclusion Art-based research in severe asthma facilitates detailed exploration of intimate and individual experiences. Darkness, impacts and resilience are common themes emerging from artworks. Understanding these experiences may help guide assessment and treatment of psychological comorbidity in the clinic.
Micellar Suzuki Cross-Coupling between Thiophene and Aniline in Water and under Air

The Suzuki–Miyaura cross-coupling reaction plays a fundamental role in modern synthetic organic chemistry, both in academia and industry. For this reason, scientists continue to search for new, more effective, cheaper and environmentally friendly procedures. Recently, micellar synthetic chemistry has been demonstrated to be an excellent strategy for achieving chemical transformations in a more efficient way, thanks to the creation of nanoreactors in aqueous environments using selected surfactants. In particular, the cheap and commercially available surfactant Kolliphor EL (a polyethoxylated castor oil derivative) has been used with success to achieve metal-catalyzed transformations in water with high yields and short reaction times, with the advantage of using air-sensitive catalysts without the need for inert atmosphere. In this work, the Kolliphor EL methodology was applied to the Suzuki cross-coupling reaction between thiophene and aniline, using the highly effective catalyst Pd(dtbpf)Cl2. The cross-coupling products were achieved at up to 98% yield, with reaction times of up to only 15 min, working at room temperature and without the need for inert atmosphere.
Evaluating the feasibility of Cas9 overexpression in 3T3-L1 cells for generation of genetic knock-out adipocyte cell lines

ABSTRACT Cell lines recapitulating physiological processes can represent alternatives to animal or human studies. The 3T3-L1 cell line is used to mimic adipocyte function and differentiation. Since transfection of 3T3-L1 cells is difficult, we used a modified 3T3-L1 cell line overexpressing Cas9 for a straightforward generation of gene knock-outs. As an example, we intended to generate 3T3-L1 cell lines deficient for adhesion G protein-coupled receptors Gpr64/Adgr2 and Gpr126/Adgr6 using the CRISPR/Cas approach. Surprisingly, all the generated knock-out as well as scramble control cell lines were unresponsive to isoprenaline in respect to adiponectin secretion and lipolysis in contrast to the wild type 3T3-L1 cells. We, therefore, analysed the properties of these stable Cas9-overexpressing 3T3-L1 cells. We demonstrate that this commercially available cell line exhibits dysfunction in cAMP signalling pathways as well as reduced insulin sensitivity independent of gRNA transfection. We tried transient transfection of plasmids harbouring Cas9 as well as direct introduction of the Cas9 protein as alternate approaches to the stable expression of this enzyme. We find that transfection of the Cas9 protein is not only feasible but also does not impair adipogenesis and, therefore, represents a preferable alternative to achieve genetic knock-out.
Optocoupler selection for high frequency power supplies

This paper analyzes and compares the linear range operation of several high speed optocouplers. These devices are evaluated by measuring current transfer ratio (CTR), gain and phase characteristics over varying input currents and ambient temperatures. The parameters are compared in graphical and tabular form, and conclusions are drawn. The optocouplers considered for the switched mode power supplies consist of LED in combination with photodiodes and phototransistors. <<ETX>>
Comparing Slope Stability and Validity for General Outcome and Specific Subskill Mastery Measurement

Abstract Progress monitoring data are central to making informed decisions on intervention intensification for struggling learners. The general outcome measure (GOM) of curriculum-based measurement of oral reading fluency (CBM-R) has been found to correlate with high-stakes assessment; however, data are highly variable, resulting in decisions that must be made 15 weeks after implementation of intervention. Recent researchers have recommended the use of both GOM and specific subskill mastery measurement (SSMM) to overcome the challenges presented with the use of GOM alone, but research on the efficacy of this approach is limited. Using Bayesian and ordinary least squares regression, we compared the GOM of CBM-R with SSMM slopes for words read correctly per minute (wcpm) per week at 5, 7, and 12 weeks, and explored the relation of the respective slopes with subsequent standardized assessment tools for struggling upper elementary students receiving word reading intervention. We found that the SSMM had a similar slope to that noted in prior research (i.e., β = 1.46 wcpm per week). This slope was significant and related to future standardized assessment outcomes across the various time points. The slope for CBM-R was not significant or related to future assessment outcomes. Implications for research and practice are discussed.
First records of Sticta weigelii s.str. from Bolivia confirmed by molecular data

The first records of Sticta weigelii s.str. from Bolivia confirmed by molecular data are presented. The species is characterized by the presence of marginal isidia, which are darker than the thallus, usually cylindrical (not flattened), thin, dark brown to black lower tomentum and often partly yellow cyphellae. Previously, the presence of S. weigelii in Bolivia was based only on a morphological concept, encompassing various unrelated species, whereas the occurrence of S. weigelii s.str. was uncertain.
The Enteric Nervous System and the Microenvironment of the Gut: The Translational Aspects of the Microbiome-Gut-Brain Axis

The proper functioning of the gastrointestinal tract is essential for digestion, absorption and the elimination of waste products. It protects us against pathogens, allergens and toxins, continuously monitoring and regulating the internal environment. The vast majority of these tasks are carried out by the nervous and immune systems of the gut in close cooperation by constantly adapting to internal and external stimuli, maintaining its homeostasis. In this review, we would like to summarize the most recent findings about the cytoarchitecture and functional microanatomy of the enteric nervous system and the immune microenvironment of the gut highlighting the essential role and inevitable molecular crosstalk between these two highly organized networks. Gut neuroimmunology is a rapidly evolving field and might help us to understand the etiology of inflammatory bowel disease and the systemic consequences of chronic intestinal inflammation. Finally, we also included a brief outlook to present the most recent research depicting the multifaceted role of the gut microbiome, its contribution to the gut-brain axis and human disease.
Morality impels employees to act: examining how ethical leaders urge employees towards knowledge sharing

ABSTRACT This study investigates when leaders can promote knowledge sharing by leading ethically? Drawing on social learning theory, we hypothesise that ethical leaders can induce knowledge sharing via role modelling. Moreover, social exchange and social capital theories explain that organisational citizenship behaviour (OCB) and normative commitment (NC) can boost knowledge sharing among employees through dual mediating effects. We collected two waves data from 506 manager-employee dyads in the banking sector of Pakistan. In addition, structural equation modelling was used to test the model, and bootstrapping was applied to examine the mediation effect. Results show that ethical leadership is positively related to employee knowledge sharing and this relationship is significantly mediated by OCB and NC parallelly. Both are equally important in accounting for the impact of ethical leadership on employee’s knowledge sharing. Our research suggests that ethical leaders can promote knowledge sharing by increasing OCB and engendering NC.
Can RUDAS Be an Alternate Test for Detecting Mild Cognitive Impairment in Older Adults, Thailand?

The Montreal Cognitive Assessment (MoCA) is the commonly used cognitive test for detecting mild cognitive impairment (MCI) in Thailand. Nevertheless, cultural biases and educational levels influence its performance. The Rowland Universal Dementia Assessment Scale (RUDAS) seems to lower the limitation of the MoCA. This study aimed to compare the performance of the RUDAS and the MoCA for the diagnosis of MCI and demonstrate the correlation between them. A cross-sectional study of 150 older participants from the outpatient setting of the Internal Medicine Department, Srinagarind Hospital, Thailand was recruited during January 2020 and March 2021. The diagnostic properties in detecting MCI of the RUDAS and the MoCA were compared. MCI was diagnosed in 42 cases (28%). The AUC for both RUDAS (0.82, 95% CI 0.75–0.89) and MoCA (0.80, 95% CI 0.72–0.88) were similar. A score of 25/30 provided the best cut-off point for the RUDAS (sensitivity 76.2%, specificity 75%) and a score of 19/30 for the MoCA had sensitivity and specificity of 76.2% and 71.3%. The Spearman’s correlation coefficient between both tests was 0.6. In conclusion, the RUDAS-Thai could be an option for MCI screening. It was correlated moderately to the MoCA.
Experimental study of threshold voltage fluctuation due to statistical variation of channel dopant number in MOSFET's

Threshold voltage fluctuation has been experimentally studied, using a newly developed test structure utilizing an 8 k-NMOSFET array. It has been experimentally shown that both V/sub th/ and the channel dopant number n/sub a/ distributions are given as the Gaussian function, and verified that the standard deviation of n/sub a/, can be expressed as the square root of the average of n/sub a/, which is consistent with statistics. In this study, it has been shown that V/sub th/ fluctuation (/spl delta/V/sub th/) is mainly caused by the statistical fluctuation of the channel dopant number which explains about 60% of the experimental results. Moreover, we discuss briefly a new scaling scenario, based on the experimental results of the channel length, the gate oxide thickness, and the channel dopant dependence of /spl delta/V/sub th/. Finally, we discuss V/sub th/ fluctuation caused by the independent statistical-variations of two different dopant atoms in the counter ion implantation process. >
Passing Parked Police Cars: Speed as a Function of Emergency Lighting, Police Car Orientation, and Driver Experience

Police vehicles and police officers working on the roadway shoulder are at risk for being struck by passing vehicles. The conspicuity of police vehicles may affect detection and speed regulation. Fifteen novice and fifteen experienced drivers participated in six experimental sessions over six months with a moderate-fidelity driving simulator. Police cars were parked on the shoulder and oriented forward or backward with their emergency lights on or off. When the emergency lights were on, drivers slowed down more than when the lights were off. The orientation of the police vehicle had minimal effects on speed changes and novice and experienced drivers did not appreciably differ in their speed regulation. When compared to the criteria of reducing speed to 60 km/h when passing an emergency vehicle, which is the law in Alberta, only 16% of all drivers reduced their speed below this limit. Results suggest that drivers do not sufficiently reduce their speed in the presence of police cars and emergency vehicles should always use their emergency lights whenever they are parked on the side of the road.
Effect of Leading-Edge Curvature on Airfoil Separation Control

Separation control on NACA 0012 and NACA 0015 airfoils was compared under incompressible conditions, using leading-edgeperiodicexcitation, in orderto assess the effect of leading-edgecurvature. Both lift and moment coefe cients were considered to compare and analyse control effectiveness. In contrast to the relatively mild NACA 0015 trailing-edge stall, NACA 0012 stall was dominated by a leading-edge bubble-bursting mechanism that gave rise to alternating intervals of partial attachment and separation, but with no regular frequency. Low-amplitude excitation downstream of the bubble enhanced poststall lift and signie cantly attenuated the associated unsteadiness. In general, larger momentum coefe cients were required for NACA 0012 separation control due to the large centrifugal acceleration of the e ow around the leading edge. Because of the different stalling characteristics, relatively high- and low-excitation frequencies were effectivefor the NACA 0012 and NACA 0015 airfoils, respectively. However, the combination of high-excitation amplitudes with relatively low frequencieswas effective on the NACA 0012, and this was believed to be associated with the large harmonic content of the evolving perturbations.
Age-related changes in work ability and injury risk in underground and open-cut coal miners

The ageing of the Australian workforce poses particular challenges to the coal-mining industry, in which 60% of the workforce is aged over 40. Preventing injury, reducing its impact, and maintaining good health in an older workforce requires better understanding of the relationships between the capacities of the older worker, the nature of the work demands, and specific injury and health issues. This project is the first study to address these issues in the Australian coal-mining industry. The objectives of the study were to: a) determine the match between work demands and work ability in Australian coal mine employees of different ages; b) determine any differences in medically related factors that may affect work ability and any influence of sector (open-cut vs. underground) and occupational category; and c) characterise those older miners who have high levels of work ability and low rates of injury, in terms of work history, individual attributes, and work patterns. Data were gathered through the administration of a cross-sectional survey among a large and representative sample of the Queensland and New South Wales coal-mining workforces. Participants included more than 1800 workers (both direct and contract employees) at 22 mine sites (both underground and open-cut operations). The Work Ability Index, developed by the Finnish Institute of Occupational Health and validated in international studies across a variety of industries, measures the capacity of workers to meet the physical and mental demands of their work. The Index, included in the survey instrument for the first time in coal mining, was supplemented by industry-specific questions relating to risk factors and exposures. The Work Ability Index score was analysed according to age, mine type and job category. The results of this study are based on workers’ own reports of their working conditions, workplace exposures, the physical and mental demands of their work, and their health status. They provide a snapshot of self-reported prevalence of injuries, musculoskeletal disorders and other health conditions. Differences in work ability and exposure status between injured and injury-free miners aged 45 and over were also examined. Increased knowledge of the ageing workforce will contribute to improvements in the management of this important resource through the development and implementation of evidence-based health promotion and injury prevention strategies. The report includes a series of recommendations in the areas of health, work organisation, work environment, education and training, and research, all aimed at supporting the health and work ability of older miners.
Part I: Participatory Ergonomics Approach to Waste Container Handling Utilizing a Multidisciplinary Team

This multidisciplinary team approach to waste container handling, developed within the Grassroots Ergonomics process, presents participatory ergonomic interpretations of quantitative and qualitative aspects of this process resulting in a peer developed training. The lower back, shoulders, and wrists were identified as frequently injured areas, so these working postures were a primary focus for the creation of the workers' training. Handling procedures were analyzed by the team to identify common cycles involving one 5 gallon (60 pounds), two 5 gallons (60 and 54 pounds), 30 gallon (216 pounds), and 55 gallon (482 pounds) containers: lowering from pallet, transporting to/from transport vehicles, loading/unloading on transport vehicles, and loading onto pallet. Eleven experienced waste container handlers participated in this field analysis. Ergonomic exposure assessment tools measuring these field activities included posture analysis, posture targeting, Lumbar Motion Monitor™(LMM), and surface electromyography (sEMG) for the erector spinae, infraspinatus, and upper trapezius muscles. Posture analysis indicates that waste container handlers maintained non-neutral lower back postures (flexion, lateral bending, and rotation) for a mean of 51.7% of the time across all activities. The right wrist was in non-neutral postures (radial, ulnar, extension, and flexion) a mean of 30.5% of the time and the left wrist 31.4%. Non-neutral shoulder postures (elevation) were the least common, occurring 17.6% and 14.0% of the time in the right and left shoulders respectively. For training applications, each cycle had its own synchronized posture analysis and posture target diagram. Visual interpretations relating to the peak force modifications of the posture target diagrams proved to be invaluable for the workers' understanding of LMM and sEMG results (refer to Part II). Results were reviewed by the team's field technicians and their interpretations were developed into ergonomic training that address the issues originally raised. This training includes intervention methods, ergonomic tools used, data acquired, and effects of waste container handling techniques on lower back, shoulder, and wrists and methods to help proactively reduce injuries associated with this profession.
TO WHAT EXTENT THE COMBINATION OF STEM LENGTH AND STEM INCLINATION DO AFFECT THE PERFORMANCE OF THE TIBIAL COMPONENT IN KNEE IMPLANTS

Mechanical loosening, instability, mechanical fractures and poor quality of bone are some factors that strongly influence the deterioration of knee implants. After a total knee replacement (TKR), proximal tibial bone suffers a resorption due to stress-shielding caused by the implant. The formation of weakening bone zones and loss of bone is one of the most clinical concerns. The aim of this work is to evaluate the geometry of the implant stem to improve the implant lifespan. A three-dimensional model of the tibial component has been generated using computerized tomographies (CT) reconstruction and CAD software. Stresses distribution at the interface bone-implant considering several combinations of stem lengths and stem inclinations have been analyzed using finite element analysis (FEA). High levels of resorption risk have been observed, when using different stem-lengths and varus inclination.
THE IMPACT OF USING INFLUENCER ON CONSUMER PURCHASE INTENTION WITH ATTITUDE TOWARDS INFLUENCER AND BRAND ATTITUDE AS MEDIATOR

This study is conducted to determine the effect of perceived credibility, trust, experience, and attractiveness as an evaluator of influencers' effectiveness on consumer purchase intention in fashion products mediated by attitude towards influencers and brand attitude. Influencers are those who regularly share content related to certain fields or skills on social media platforms. This study is based on the Theory of Planned Behavior (TPB) and other previous studies related to influencers' effectiveness on purchase intention of fashion products. The population in this study is 385 women in Surabaya with a non-probability sampling method using a purposive sampling technique. The data analysis method used in this study is Structural Equation Modeling-Partial Least Square (SEM PLS) with a smart PLS 3.0 program. The analysis results in this study show that perceived credibility, trust, and attractiveness have a positive and significant effect on attitude towards influencers. In contrast, perceived expertise has a negative and insignificant impact on attitude towards influencers. Attitude towards influencers fully mediates the influence of perceived credibility, trust, and attractiveness on brand attitude and purchase intention. Brand attitude fully mediates the influence of attitude towards influencers on purchase intention. In this study, variable perceived expertise used did not affect attitude towards influencer variables. This is different from previous studies that have been done before. For further researchers, it is suggested that they can again use perceived expertise and other variables that can support more deep assessments that give rise to consumer attitudes towards an advertisement made by fashion product influencers in subsequent studies using different populations. The analysis model that has been used in this study can then be reused in conducting further research with varying numbers of populations and types.