Miracle-dz/UniFAR-FTUs huggingface dataset:
Inﬂuence of potassium fertilization and foliar application of zinc and phosphorus on growth, yield components, yield and ﬁber properties of Egyptian cotton ( Gossypium barbadense L.)

Aims Supplying optimal quantities of mineral nutrients to growing crop plants is one way to improve crop yields. Nutrients need to be used rationally in order to avoid a negative ecological impact and undesir-able effects on the sustainability of agricultural production systems. Excessive application of nutrients also affects the farmer’s economy. In order to calculate the amount of fertilizer to be applied to crops, it is necessary to develop recommendation programmers that adjust nutrient rates to crop requirements. Experiments in two successive seasons were conducted to investigate the effect of K fertilization and foliar application of Zn and P on yield and ﬁber properties of cotton cv. Giza 86. Potassium (0.0 and 47.4 kg of K ha (cid:1) 1 ) was soil applied, while chelated zinc (0.0 and 57.6 g of Zn ha (cid:1) 1 , applied twice at 70 and 85 days after sowing ‘DAS’) and phosphorus (0.0, 576, 1 152 and 1 728 g of P ha (cid:1) 1 , applied twice at 80 and 95 DAS) were applied to the foliage. chlorophyll and P uptake of bolls boll seed lint seed cotton cotton and lint yield ha (cid:1) 1 and earliness of harvest increased with the application of K, Zn and P. Treatments generally had no signiﬁcant effect on lint percentage and ﬁber properties, with exceptions, for micronaire reading and ﬂat bundle strength, and uniformity ratio, where the mean values of these characters were signiﬁcantly increased over the untreated control by applying K, and for the micronaire reading in the ﬁrst season, when applying P at 1 728 g ha (cid:1) 1 , and uniformity ratio in the second season, when applying Pat 1 152 and 1 728 g ha (cid:1) 1 , where the mean values of these characters were signiﬁcantly increased over the untreated control by applying P. Under the conditions of this study, applying K fertilization at 47.4 kg ha (cid:1) 1 combined with spraying cotton plants with zinc at 57.6 g ha (cid:1) 1 and also with P at 1 728 g ha (cid:1) 1 improved growth and yield of Egyptian cotton.
(cid:1) 1 ( KCNMB1 ) Subunits Mediate Lithocholate Activation of Large-Conductance Ca 2 (cid:1) -Activated K (cid:1) Channels and Dilation in Small, Resistance-Size Arteries □

Among the nongenomic effects of steroids, control of vaso- motion has received increasing attention. Lithocholate (LC) and other physiologically relevant cholane-derived steroids cause vasodilation, yet the molecular targets and mechanisms underlying this action remain largely unknown. We demonstrate that LC (45 (cid:2) M) reversibly increases the diameter of pressurized resistance cerebral arteries by (cid:2) 10%, which would result in (cid:2) 30% increase in cerebral blood flow. LC action is independent of endothelial integrity, prevented by 55 nM iberiotoxin, and unmodified by 0.8 mM 4-amino-pyridine, indicating that LC causes vasodilation via myocyte BK channels. Indeed, LC activates BK channels in isolated myocytes through a destabilization of channel long-closed states without modifying unitary conductance. LC channel activation occurs within a wide voltage range and at Ca 2 (cid:1) concentrations reached in the myocyte at rest and during contraction. Channel accessory (cid:1) 1 subunits, which are pre- dominant in smooth muscle, are necessary for LC to modify channel activity. In contrast, (cid:1) 4 subunits, which are predom- inant in neuronal tissues, fail to evoke LC sensitivity. LC activation of cbv1 (cid:1) (cid:1) 1 and native BK channels display identical characteristics, including EC 50 (46 (cid:2) M) and E max ( (cid:3) 300 (cid:2) M) values, strongly suggesting that the cbv1 (cid:1) (cid:1) 1 complex is necessary and sufficient to evoke LC action. Finally, intact arteries from (cid:1) 1 subunit knockout mice fail to relax in re- sponse to LC, although they are able to respond to other vasodilators. This study pinpoints the BK (cid:1) 1 subunit as the molecule that senses LC, which results in myocyte BK channel activation and, thus, endothelial-independent relaxation of small, resistance-size arteries.
ENTREPRENEURSHIP EDUCATION, INFORMATION LITERACY, AND ENTREPRENEURIAL INTERESTS: AN EMPIRICAL STUDY

This study aims to determine the effect of entrepreneurship education in family and information literacy on student entrepreneurial interest in SMK Negeri 1 Makassar. The current study applied descriptive quantitative research. It was conducted at SMK Negeri 1 Makassar in September 2019 to October 2019. The population in this study were students majoring in Marketing of SMK Negeri 1 Makassar. Sampling was done by Probability Sampling technique so that 73 students as sample was obtained. Findings of this study indicate that entrepreneurship education in family does not partially affect on entrepreneurial interest. While information literacy partially affect on entrepreneurial interest. The effect of entrepreneurship education in family and information literacy are simultaneously positive and significant on the entrepreneurial interest of students of SMK Negeri 1 Makassar.
Toward Computational Fluency in Multidigit Multiplication and Division.

problem situations yields greater problem-solving competence and equal or better computational competence. Children who start with problem situations directly model solutions to these problems. They later move to more advanced mathematical approaches as they progress through levels of solutions and problem difficulty. Thus, their development of computational fluency and their acquisition of problem-solving skills are intertwined as both develop with understanding.
CMAR_A_309092 4241..4250

1Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea; 2Department of Pathology and Translational Genomics, Samsung Medical Center, Sungkyunkwan University College of Medicine, Seoul, Korea; 3Samsung Genome Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea; 4Department of Health Sciences and Technology, Samsung Advanced Institute for Health Sciences and Technology, Sungkyunkwan University, Seoul, Korea Background: This study explored the efficacy of lenalidomide plus rituximab for patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL) including cases of secondary central nervous system (CNS) involvement and transformed follicular lymphoma (FL) in real-world context because of anti-tumor effect and blood–brain barrier permeability of lenalidomide. Methods: Twenty-four patients including relapsed or refractory DLBCL (n = 21) including seven patients with secondary CNS involvement and transformed FL (n = 3) were retrospectively analyzed. Results: Based on the best response, the complete response (CR) rate was 21% (5/24) and the overall response rate (ORR) was 38% (9/24). However, as all cases of transformed FL (n = 3) did not respond, all responders had DLBCL, and the CR and ORR rates of DLBCL were 24% (5/21) and 43% (9/21), respectively. The median number of treatment cycles was only two (range: 1–7) due to frequent occurrence of early progression, and 18 patients died and the cause of death was disease progression. The response rate was not significantly different among patients with and without secondary CNS involvement. The median post-treatment overall and progression-free survival were 7.3 and 1.8 months, respectively. Hematologic toxicities were common adverse events, but most hematologic toxicities were manageable. There were no serious infectious complications or treatment-related mortality. Conclusion: Lenalidomide plus rituximab might be a salvage therapy for relapsed or refractory DLBCL, especially in case of secondary CNS involvement. However, the addition of other agents should be considered to prolong the duration of response.
Inﬂuence of the Pseudomonas Quinolone Signal on Denitriﬁcation in Pseudomonas aeruginosa (cid:1)

Denitriﬁcation is a well-studied respiratory system that is also important in the biogeochemical nitrogen cycle. Environmental signals such as oxygen and N-oxides have been demonstrated to regulate denitriﬁcation, though how denitriﬁcation is regulated in a bacterial community remains obscure. Pseudomonas aeruginosa is a ubiquitous bacterium that controls numerous genes through cell-to-cell signals. The bacterium possesses at least two N -acyl- L -homoserine lactone (AHL) signals. In our previous study, these quorum-sensing signals controlled denitriﬁcation in P. aeruginosa . In addition to the AHL signals, a third cell-to-cell communication signal, 2-heptyl-3-hydroxy-4-quinolone, referred to as the Pseudomonas quinolone signal (PQS), has been characterized. In this study, we examined the effect of PQS on denitriﬁcation to obtain more insight into the respiratory regulation in a bacterial community. Denitriﬁcation in P. aeruginosa was repressed by PQS, which was partially mediated by PqsR and PqsE. Measuring the denitrifying enzyme activities indicated that nitrite reductase activity was increased by PQS, whereas PQS inhibited nitric oxide reductase and the nitrate-respiratory chain activities. This is the ﬁrst report to demonstrate that PQS inﬂuences enzyme activities, suggesting this effect is not speciﬁc to P. aeruginosa . Furthermore, when iron was supplied to the PQS-added medium, denitrifying activity was almost restored, indicating that the iron chelating property of PQS affected denitriﬁcation. Thus, our data indicate that PQS regulates denitriﬁcation primarily through iron chelation. The PQS effect on denitriﬁcation was relevant in a condition where oxygen was limited and denitriﬁcation was induced, suggesting its role in controlling denitriﬁcation where oxygen is present. the air of butyl-rubber-sealed Hungate tubes or Erlenmeyer ﬂasks was replaced with argon by ﬂushing gas through a needle. Anaerobic growth, denitriﬁcation activity, and transcriptional activity were measured using 17-ml Hungate tubes containing 5 ml LBN medium (LB medium supplemented with 100 mM KNO 3 ) incubated at 37°C with shaking at 200 rpm. Oxygen-limiting experiments were carried out by using butyl-rubber-sealed 17-ml Hungate tubes containing 2 ml LBN medium incubated at 37°C with shaking at 170 rpm. Cells used to determine denitrifying enzyme activities were anaerobically cultured in a 500-ml Erlenmeyer ﬂask containing 80 ml LBN at 37°C and 200 rpm. The pqsA transcriptional fusion plasmid was constructed by cloning the promoter region of pqsA (59), using pmpqsAF3 and pmpqsAR PCR primers (Table 1), into the multicloning site of pMEX9 reporter plasmid. Plasmids were transformed into P. aeruginosa strain PAO1 by electroporation (20). Complementation plasmids carrying pqsR or pqsE were constructed by cloning each gene into the multicloning site of pUCP24. cpqsRF/cpqsRR or cpqsEF/cpqsER primer pairs 1) were used to amplify pqsR and pqsE , respectively.
Risk-Sharing and Investment in Concentrated Markets∗

We study investment and risk sharing in complete markets when agents internalize their impact on asset prices. Quantity shading of state-contingent claims by buyers and sellers generates excess exposure to idiosyncratic risk and low asset pledgeability. This depresses investment, the risk-free rate, and aggregate productivity. Rents from market power distort and misalign agents’ marginal valuations of state-contingent returns, rendering risk-sharing constrained inefficient and as if markets were competitive but incomplete. When there is limited commitment, sellers face borrowing constraints that limit their ability to strategically restrict supply, thereby reallocating market power to buyers. When markets are decentralized, agents distort investment to capture arbitrage profits by acting as pass-through intermediaries. ∗We thank Jonathan Berk, John Hatfield, Yiming Ma, Gregor Matvos, Aaron Pancost, Neng Wang, and seminar participants at UT Austin for helpful comments. We thank Mahyar Sefidgaran for excellent research assistance. †UT Austin. daniel.neuhann@mccombs.utexas. edu ‡UT Austin. michael.sockin@mccombs.utexas. edu Electronic copy available at: https://ssrn.com/abstract=3320035
Kobe University Repository : Kernel タイトル Tit le Polynomial conserved quant it ies of Lie applicable surfaces 著者

Using the gauge theoretic approach for Lie applicable surfaces, we characterise certain subclasses of surfaces in terms of polynomial conserved quantities. These include isothermic and Guichard surfaces of conformal geometry and L-isothermic surfaces of Laguerre geometry. In this setting one can see that the well known transformations available for these surfaces are induced by the transformations of the underlying Lie applicable surfaces. We also consider linear Weingarten surfaces in this setting and develop a new Bäcklund-type transformation for these surfaces.
Using TLS-Measured Tree Attributes to Estimate Aboveground Biomass Biomass in Small Black Spruce Trees

: Research Highlights : This study advances the effort to accurately estimate the biomass of trees in peatlands, which cover 13% of Canada’s land surface. Background and Objectives: Trees remove carbon from the atmosphere and store it as biomass. Terrestrial laser scanning (TLS) has become a useful tool for modelling forest structure and estimating the above ground biomass (AGB) of trees. Allometric equations are often used to estimate individual tree AGB as a function of height and diameter at breast height (DBH), but these variables can often be laborious to measure using traditional methods. The main objective of this study was to develop allometric equations using TLS-measured variables and compare their accuracy with that of other widely used equations that rely on DBH. Materials and Methods : The study focusses on small black spruce trees (<5 m) located in peatland ecosystems of the Taiga Plains Ecozone in the Northwest Territories, Canada. Black spruce growing in peatlands are often stunted when compared to upland black spruce and having models speciﬁc to them would allow for more precise biomass estimates. One hundred small trees were destructively sampled from 10 plots and the dry weight of each tree was measured in the lab. With this reference data, we ﬁtted biomass models speciﬁc to peatland black spruce using DBH, crown diameter, crown area, height, tree volume, and bounding box volume as predictors. Results: Our best models had crown size and height as predictors and outperformed established AGB equations that rely on DBH. Conclusions: Our equations are based on predictors that can be measured from above, and therefore they may enable the plotless creation of accurate biomass reference data for a prominent tree species in a common ecosystem (treed peatlands) in North America’s boreal.
Pharmacological and behavioral profile of ACP-103, a novel 5-HT 2A receptor inverse agonist

The in vitro and in vivo pharmacological properties of ACP-103 [ N -(4-fluorophenylmethyl)- N -(1-methylpiperidin-4-yl)- N’ -(4-(2-methylpropyloxy)phenylmethyl)carbamide (2 R ,3 R )-dihydroxybutanedioate (2:1)] are presented. A potent 5-HT 2A receptor inverse agonist, ACP-103 competitively antagonized the binding of [ 3 H]-ketanserin to heterologously expressed human 5HT 2A receptors with a mean pK i of 9.3 in membranes and 9.70 in whole cells. ACP-103 displayed potent inverse agonist activity in the cell-based functional assay R-SAT, with a mean pIC 50 of 8.7. ACP-103 demonstrated lesser affinity (mean pK i 8.80, membranes, and 8.00, whole cells, as determined by radioligand binding) and potency as an inverse agonist (mean pIC 50 7.1 in R-SAT) at human 5-HT 2C receptors, and lacked affinity and functional activity at 5HT 2B receptors, dopamine D 2 receptors, and other human monoaminergic receptors. Behaviorally, ACP-103 attenuated head twitch behavior (3 mg/kg, p.o.) and prepulse inhibition deficits (1 – 10 mg/kg, s.c.) induced by the 5-HT 2A receptor agonist (±)-2,5-dimethoxy-4-iodoamphetamine hydrochloride (DOI) in rats and reduced the hyperactivity induced in mice by the N -methyl- D -aspartate receptor non-competitive antagonist, MK-801, (0.1 and 0.3 mg/kg, s.c.; 3 mg/kg, p.o.) consistent with a 5-HT 2A receptor mechanism of action in vivo and antipsychotic-like efficacy. ACP-103 demonstrated > 42.6% oral bioavailability in rats. Thus, ACP-103 is a potent,
Development of the near wake behind a horizontal axis wind turbine - including the development of a free wake lifting line code

A lot of research has been carried out in the past on wind turbine wake aerodynamics. Models exist for both the near field and the far wake. The near wake is governed by a typical vortex structure that gradually decays due to viscous and turbulent mixing effects, forming the less structured far wake region. The formation of the far field from the rotor region and near wake is not completely understood yet. In this thesis an attempt is made to develop a simple model that tries to capture the decay of the vortex wake within the first two diameters downstream of the rotor. A free wake lifting line vortex model has been developed. Viscous effects have been added to the vortex code in the form of vortex core models and a simple model that describes the turbulent decay of circulation as a function of ambient turbulence intensity. Furthermore models for simulating wind shear and the presence of the nacelle have been implemented. A thorough validation study of the model has been carried out by means of hot-film and Particle Image Velocimetry (PIV) measurements. Close to the rotor the model compares well with the induced velocities measured with a hot-film. PIV measurements show that the model captures the position of the tip vortex quite well within the first diameter downstream. The measured velocity field can however not be reproduced correctly by the code. No measurements were available that can validate the turbulent decay of the vortex wake; instead suggestions are made for an experiment in the Open Jet Facility of the faculty of Aerospace Engineering The new model is only valid in the region of the wake where the vortex structure of the wake is still in tact which is typically between one or two diameters downstream. Further downstream the outputs from the model may be used as an input for a Reynolds Averaged Navier-Stokes (RANS) model that describes the far wake of the rotor.
Function Peroxisome proliferator-activated receptor- (cid:2) expression induces alterations in cardiac myoﬁlaments in a pressure-overload model of hypertrophy

Peroxisome proliferator-activated receptor- (cid:2) expression induces alterations in cardiac myoﬁlaments in a pressure-over-load model of hypertrophy. Am Physiol Heart Physiol ajpheart.00469. 2016. —Although alterations in fatty acid (FA) metabolism have been shown to have a negative impact on contractility of the hypertrophied heart, the targets of action remain elusive. In this study we compared the function of skinned ﬁber bundles from transgenic (Tg) mice that overexpress a relatively low level of the peroxisome proliferator-activated receptor (cid:2) (PPAR (cid:2) ), and nontransgenic (NTg) littermates. The mice (NTg-T and Tg-T) were stressed by transverse aortic constriction (TAC) and compared with shams (NTg-S and Tg-S). There was an approximate 4-fold increase in PPAR (cid:2) expression in Tg-S compared with NTg-S, but Tg-T hearts showed the same PPAR (cid:2) expression as NTg-T. Expression of PPAR (cid:2) did not alter the hypertrophic response to TAC but did reduce ejection fraction (EF) in Tg-T hearts compared with other groups. The rate of actomyosin ATP hydrolysis was signiﬁcantly higher in Tg-S skinned ﬁber bundles compared with all other groups. Tg-T hearts showed an increase in phosphorylation of speciﬁc sites on cardiac myosin binding protein-C (cMyBP-C) and (cid:3) -myosin heavy chain isoform. These results advance our understanding of potential signaling to the myoﬁlaments induced by altered FA metabolism under normal and pathological states. We demonstrate that chronic and transient PPAR (cid:2) activation during pathological stress alters myoﬁlament response to Ca 2 (cid:4) through a mechanism that is possibly mediated by MyBP-C phosphorylation and myosin heavy chain isoforms. NEW & NOTEWORTHY Data presented here demonstrate novel signaling to sarcomeric proteins by chronic alterations in fatty acid metabolism induced by PPAR (cid:2) . The mechanism involves modiﬁcations of key myoﬁlament regulatory proteins modifying cross-bridge dynamics with differential effects in controls and hearts stressed by pressure overload. phosphorylation of cMyBP-C in the Tg-T group associated with a signiﬁcant decrease in ejection fraction (EF) compared with other groups. Our results indicate that chronic and possibly transient upregulation of PPAR (cid:2) is not beneﬁcial as a means to counter reduced PPAR (cid:2) activation in hypertrophied hearts. PPAR (cid:2) upregulation induces a metabolic inﬂexibility in the opposite polarity of that observed in hypertrophied hearts, and so induces deleterious effects on contractility. Potentially, the reduced PPAR activity in the hypertrophied hearts is an adaptive mechanism to preserve contractile activity in cardiac
Investigation of the Microbiological and Biochemical Properties of Kimchi in the Submerged Model System Designed for Fermented Sausages

The objective of this study was to investigate the potential of the application of lactic acid bacteria (LAB) from kimchi as a starter culture in the production of fermented sausages. To achieve this, a submerged model medium that contained LAB as part of a complex system of kimchi (0.5, 1.0, 1.0, 3.0, and 5.0%) and lyophilized kimchi powder (0.2 and 0.5%) was fermented for 120 h. During the fermentation period, the growth of total viable organisms and LAB, and the changes in the pH and the titratable acidity, were investigated. The initial LAB counts ranged from 6.4 to 7.7 Log CFU/mL for the kimchi media, and from 6.9 to 6.9 Log CFU/mL for the kimchi powder media. In all the kimchi batches, the LAB increased logarithmically, and the highest LAB counts (around 9 Log CFU/mL) were reached in 24 h. An evident lag phase of the LAB was observed in the kimchi powder samples and reached 8.8 Log CFU/mL in 8 h. The decrease in the pH and the formation of lactic acid were rapid in the kimchi batches, and reached pH values of 3.4-3.5 in 12 h. With these results, the LAB that was integrated with the addition of kimchi or kimchi powder demonstrated its potential utility as a substitute for starter culture.
Integration of Transforming Growth Factor (cid:2) and RAS Signaling Silences a RAB5 Guanine Nucleotide Exchange Factor and Enhances Growth Factor-Directed Cell Migration (cid:1)

Transforming growth factor (cid:1) (TGF- (cid:1) ) receptor (T (cid:1) R) signaling contributes to normal development as well as tumorigenesis. Here we report that RIN1, a RAB5 guanine nucleotide exchange factor (GEF) and down regulator of receptor tyrosine kinases (RTKs), promotes T (cid:1) R signaling through enhanced endocytosis. T (cid:1) R activation induces SNAI1 (Snail), a transcription repressor that reduces RIN1 expression, providing a negative feedback mechanism to control T (cid:1) R trafﬁcking and downstream signaling. Persistent RAS signaling disrupts this equilibrium by stabilizing SNAI1 protein, resulting in strong silencing of RIN1 and stabilization of RTKs. TGF- (cid:1) -induced RIN1 silencing in breast cancer cells prolonged sensitivity to hepatocyte growth factor, a ligand for the MET-type RTK, and enhanced growth factor-directed cell motility. We conclude that in some tumor cells T (cid:1) R and RAS signals are integrated through the silencing of RIN1, leading to a reduction in RAB5-mediated endocytosis. These ﬁndings shed new light on the basis for distinct interpretations of TGF-