Miracle-dz/UniFAR-FTUs huggingface dataset:
The Jurassic of North-East Greenland

The Jurassic rift succession of East Greenland has been intensely studied over the last 25 years, particularly within the main outcrop areas of Jameson Land and Wollaston Forland. The more isolated and poorly known outcrops on Traill O, Hold with Hope, Hochstetter Forland and Store Koldewey were investigated in the late 1980s and mid-1990s in order to develop a better regional understanding of the Jurassic in eastern Greenland. This collection of seven papers focuses on stratigraphic and depositional aspects of the Jurassic at these localities. Comprehensive descriptions of the Jurassic on Hold with Hope and south-eastern Traill O are accompanied by papers covering fluvial deposits and new ammonite collections from the Middle Jurassic of Traill O. The bulletin is concluded by studies of the dinoflagellate cyst stratigraphy of the Middle and Upper Jurassic of Hold with Hope, Hochstetter Forland and Store Koldewey.
Evaluating the Effectiveness of a Live Musical Theater-Based Approach to Child Sexual Abuse Prevention in Elementary Schools

ABSTRACT Hugs and Kisses is a theater-based child sexual abuse (CSA) prevention program designed for children in kindergarten through fifth grades. The purpose of this cross-sectional case study is to evaluate how a comprehensive live musical theater program can prepare teachers to discuss and identify the signs of CSA, help children increase their knowledge, and learn prevention strategies to stop CSA in the future. A total of 154 teachers and 2,700 children from 31 schools participated in this program during 2016. Findings show this program increases children’s awareness of touch and action knowledge through five primary safety lessons taught during the program and reinforced by a teacher led in-person discussion after the play. Nearly 85% of the students across all grade levels in this sample understood the lessons taught in the play, and students whose teachers held an in-class discussion after the play scored better than those students whose teachers did not hold a discussion. Teachers who were prepared with training resources also held longer in-class discussions compared to those who were not prepared. The Hugs play has the potential to be a national model for evidence-based CSA programs.
Smaller-Incision new-generation implantable miniature telescope: Three-months follow-up study.

PURPOSE To evaluate three months follow-up of SING IMT implant in patients affected by late-stage AMD. DESIGN Prospective cohort study. SUBJECTS In a total of 80 eyes of 40 patients who underwent the enrollment tests, 11 patients' eyes affected by late-stage AMD matched the inclusion criteria and underwent SING IMT implant from February to June 2022. METHODS Before surgery, each patient underwent the enrollment examination to verify inclusion and exclusion criteria. MAIN OUTCOME MEASURES BCVA for distance and for near, IOP, ACD and ECD were evaluated at 1 and 3 months follow up. Also quality of life in doing the activities of daily life was evaluated. RESULTS BCVA for distance and for near improved from baseline to 3 months follow up (23.91 ± 9.418 ETDRS letters and 59.09 ± 11.58 ETDRS letters respectively (p < 0.001). An endothelial cell loss was shown (p < 0.001), with a rate of cell density reduction around 8.3% (baseline vs 3 months). CONCLUSIONS SING IMT could be a valid surgical device to improve patients' sight and quality of life which have been deteriorated by late-stage macular degeneration. Further studies with more patients and longer follow up are needed to confirm our results.
Long-term Recovery - Review of sediment condition at Marine Farm lease No. 76 (Gunpowder Jetty), North West Bay

This study was undertaken to assess the Gunpowder Jetty site(Marine Farm lease No.76) 10 years after it was finally vacated to determine whether the benthic, visual and physical chemical conditions were consistent with background conditions and to what extent the system has recovered. The results suggest that, based on the selected environmental condition variables assessed, the sediments around the Gunpowder lease have largely recovered. Whilst some parameters still showed small differences between locations these do not appear to be having a major effect on the ecology or nutrient mineralisation processes and consequently there is no evidence that the farming activity has had any permanent impact on the ecology in this area.
Harnessing Acoustic Dispersions in YX-LN/SiO2/Si SH-SAW Resonators for Electromechanical Coupling Optimization and Rayleigh Mode Suppression

In this study, we investigate the dispersive behavior of the electromechanical coupling coefficient (<inline-formula> <tex-math notation="LaTeX">${k}_{\text {eff}}^{{2}}$ </tex-math></inline-formula>) for shear-horizontal (SH) and Rayleigh surface acoustic wave (SAW) modes in a YX-LiNbO3 (LN)/SiO2/Si substrate across various wavelengths. Due to the difference in velocity dispersion between the SH and Rayleigh modes, mode coupling can be observed when these two modes operate at closely proximate frequencies, leading to a notable variation in their <inline-formula> <tex-math notation="LaTeX">${k}_{\text {eff}}^{{2}}$ </tex-math></inline-formula>. With a careful design, SH and Rayleigh modes can be tuned to achieve a mode-decoupling state for enhancing <inline-formula> <tex-math notation="LaTeX">${k}_{\text {eff}}^{{2}}$ </tex-math></inline-formula> of the SH-SAW and suppressing the presence of the Rayleigh mode in YX-LN/SiO2/Si. Consequently, a series of proof-of-concept SH-SAW resonators with wavelengths (<inline-formula> <tex-math notation="LaTeX">$\lambda $ </tex-math></inline-formula>) ranging from 1.6 to <inline-formula> <tex-math notation="LaTeX">$4.8 ~\mu \text{m}$ </tex-math></inline-formula> are fabricated. The optimized resonator with a <inline-formula> <tex-math notation="LaTeX">$\lambda $ </tex-math></inline-formula> of <inline-formula> <tex-math notation="LaTeX">$2.8 ~\mu \text{m}$ </tex-math></inline-formula> exhibits a resonant frequency of 1.064 GHz, an effective <inline-formula> <tex-math notation="LaTeX">${k}_{\text {eff}}^{{2}}$ </tex-math></inline-formula> of 47.7%, a maximum Bode-<inline-formula> <tex-math notation="LaTeX">${Q}$ </tex-math></inline-formula> of around 900, and an 18-dB rejection of spurious modes spanning from 0.5 to 3 GHz, without the presence of the Rayleigh mode.
The development and experimental validation of hypoxia-related long noncoding RNAs prognostic signature in predicting prognosis and immunotherapy of cutaneous melanoma

Cutaneous melanoma (CM) is widely acknowledged as a highly aggressive form of malignancy that is associated with a considerable degree of morbidity and poor prognosis. Despite this recognition, the precise role of hypoxia-related long noncoding RNAs (HRLs) in the pathogenesis of CM remains an area of active research. This study sought to elucidate the contribution of HRLs in CM by conducting a thorough screening and extraction of hypoxia-related genes (HRGs). In particular, we conducted univariate and multivariate Cox regression analyses to assess the independence of the prognostic signature of HRLs. Our results demonstrated that a novel risk model could be established based on five prognostic HRLs. Remarkably, patients with low-risk scores exhibited significantly higher overall survival rates compared to their high-risk counterparts, as confirmed by Kaplan-Meier survival analysis. Furthermore, we utilized consensus clustering analysis to categorize CM patients into two distinct subtypes, which revealed marked differences in their prognosis and immune infiltration landscapes. Our nomogram results confirmed that the HRLs prognostic signature served as an independent prognostic indicator, offering an accurate evaluation of the survival probability of CM patients. Notably, our findings from ESTIMATE and ssGSEA analyses highlighted significant disparities in the immune infiltration landscape between low- and high-risk groups of CM patients. Additionally, IPS and TIDE results suggested that CM patients in different risk subtypes may exhibit favorable responses to immunotherapy. Enrichment analysis and GSVA results indicated that immune-related signaling pathways may mediate the role of HRLs in CM. Finally, our tumor mutation burden (TMB) results indicated that patients with low-risk scores had a higher TMB status. In summary, the establishment of a risk model based on HRLs in this study provided an accurate prognostic prediction and correlated with the immune infiltration landscape of CM, thereby providing novel insights for the future clinical management of this disease.
Determinants of incomplete childhood hepatitis B vaccination in Sierra Leone, Liberia, and Guinea: Analysis of national surveys (2018–2020)

Abstract Vaccination against hepatitis B virus (HBV) is effective at preventing vertical transmission. Sierra Leone, Liberia, and Guinea are hyperendemic West African countries; yet, childhood vaccination coverage is suboptimal, and the determinants of incomplete vaccination are poorly understood. We analyzed national survey data (2018–2020) of children aged 4–35 months to assess complete HBV vaccination (receiving 3 doses of the pentavalent vaccine) and incomplete vaccination (receiving <3 doses). Statistical analysis was conducted using the complex sample command in SPSS (version 28). Multivariate logistic regression was used to identify determinants of incomplete immunization. Overall, 11,181 mothers were analyzed (4,846 from Sierra Leone, 2,788 from Liberia, and 3,547 from Guinea). Sierra Leone had the highest HBV childhood vaccination coverage (70.3%), followed by Liberia (64.6%) and Guinea (39.3%). Within countries, HBV vaccination coverage varied by socioeconomic characteristics and healthcare access. In multivariate regression analysis, factors that were significantly associated with incomplete vaccination in at least one country included sex of the child, Muslim mothers, lower household wealth index, <4 antenatal visits, home delivery, and distance to health facility vaccination (all p < 0.05). Understanding and addressing modifiable determinants of incomplete vaccination will be essential to help achieve the 2030 viral hepatitis elimination goals.
Basement Double-wedge Thrusting in the Northern Sierras Pampeanas of Argentina (27S)Constraints from Deep Seismic Reflection

Deep seismic reprocessing of industrial lines, combined with surface geologic and structural data, provides the basis of a new tectonic interpretation of the northern Sierras Pampeanas at 27S latitude. These basement mountain blocks, uplifted during an episode of shallowing of the subduction zone, show an active double-wedge thrusting. Deep seismic data indicate the different vergences of the western and eastern sectors of the Sierra de Aconquija, in the western Sierras Pampeanas at this latitude. Neotectonic evidence reveals that both systems are active, although the western sector has been active since at least middle to late Miocene times and recorded a much greater uplift and horizontal displacement than did the east. The eastern sector, although presently active, recorded only minor uplift and displacement. These facts enable correlation of the events in the northern Sierras Pampeanas with analog and numerical models that predict the behavior of double-wedge thrusting. A by-product of this analysis is the knowledge that a middle Miocene Atlantic transgression covered the entire region, prior to the uplift of the Sierra de Aconquija. Based on correlation of the foreland basin deposits on both sides of the range, two stages of development are recognized. A single foreland basin covered the study area at an early stage, during the marine transgression (13.5 Ma), and at a late stage, a broken foreland basin developed.
Prevalence and distribution of subtypes of Blastocystis in Asiatic brush-tailed porcupines (Atherurus macrourus), bamboo rats (Rhizomys pruinosus), and masked palm civets (Paguma larvata) farmed in Hainan, China

Blastocystis sp. is an important gastrointestinal parasite with global distribution, prevalent in humans, farmed animals, and wildlife. Therefore, this study aimed to investigate the prevalence and genetic diversity of Blastocystis sp. in Asiatic brush-tailed porcupines (Atherurus macrourus), bamboo rats (Rhizomys pruinosus), and masked palm civets (Paguma larvata) in Hainan Province, China. A total of 900 fecal samples were collected from three farmed animal species including 257 porcupines, 360 rats, and 283 civets. Genomic DNA was extracted from each fecal sample and Blastocystis sp. was detected by PCR at the small subunit ribosomal RNA (SSU rRNA) gene. A phylogenetic tree was constructed using the maximum likelihood method. Blastocystis sp. was detected in 47 (5.2%) fecal samples: 12 (4.7%) Asiatic brush-tailed porcupines, 8 (2.2%) bamboo rats, and 27 (9.5%) masked palm civets. Three known Blastocystis sp. subtypes, including ST1, ST4, ST5, and one unnamed subtype (unST), were found in one, 19, 26, and one animal, respectively. Subtypes ST4 and unST were detected in porcupines, ST4 in rats, and ST1 and ST5 in civets. Our results suggest that the three farmed animal species reported in this study could serve as reservoirs for potentially zoonotic Blastocystis sp. subtypes and transmit this parasite to humans, other farmed animals, and wildlife.
Hypersensitivity to opening of ATP-sensitive potassium channels in post-traumatic headache

Objective To investigate whether levcromakalim (a KATP channel opener) induces migraine-like headache in people with persistent post-traumatic headache who had no known history of migraine. Methods In a randomized, double-blind, placebo-controlled, 2-way crossover trial, participants were randomly assigned to receive a 20-minute continuous intravenous infusion of levcromakalim (50 µg/mL) or placebo (isotonic saline) on two separate experimental days with a 1-week wash-out period in between. The primary endpoint was the difference in incidence of migraine-like headache between levcromakalim and placebo during a 12-hour observational period after infusion start. The secondary endpoint was the difference in area under the curve for baseline-corrected median headache intensity scores between levcromakalim and placebo during the 12-hour observational period. Results A total of 21 participants with persistent post-traumatic headache were randomized and completed the trial. During the 12-hour observational period, 12 (57%) of 21 participants reported experiencing migraine-like headache following the levcromakalim infusion, compared with three after placebo (P = 0.013). Moreover, the baseline-corrected median headache intensity scores were higher following the levcromakalim infusion than after placebo (P = 0.003). Conclusion Our findings suggest that KATP channels play an important role in the pathogenesis of migraine-like headache in people with persistent post-traumatic headache. This implies that KATP channel blockers might represent a promising avenue for drug development. Further research is warranted to explore the potential therapeutic benefits of KATP channel blockers in managing post-traumatic headache. Trial Registration: ClinicalTrials.gov Identifier: NCT05243953
Evaluating isotopic equilibrium among sulfide mineral pairs in archean ore deposits: case study from the Kidd Creek VMS deposit, Ontario, Canada

Recent developments in the measurement of δ34S and δ33S in sulfide minerals provide a new framework to evaluate isotopic equilibrium among sulfide minerals and a new tool to investigate mineralizing processes or sources of sulfur in ore-forming systems. Isotopic equilibrium requires that values of δ34S and δ33S are highly correlated between mineral pairs and that deviations (quantified as Δ33S) from a reference mass-dependent fractionation are the same for both minerals within experimental error. In this contribution, we apply this framework for the first time to natural samples, and evaluate isotopic equilibrium among sulfide minerals from the Archean Kidd Creek volcanogenic massive sulfide deposit in Ontario, Canada. Two of eight sulfide mineral pairs showed clear isotopic disequilibrium, in agreement with interpreted paragenetic relationships; six other pairs have isotopic compositions that are consistent with equilibrium. We discuss the implications of these results for the interpretation of mineral paragenesis and sulfur isotope geothermometry at Kidd Creek. This technique offers new possibilities for evaluating sulfur isotope systematics in Archean (>2.45 Ga) ore deposits, in which the range of δ34S values is small but non-zero values of Δ33S are common.
Prognostic Accuracy of the Different Scoring Systems for Assessing Coagulopathy in Sepsis: A Retrospective Study

There is no gold standard for the diagnosis of coagulation dysfunction in sepsis, and the use of the current scoring systems is still controversial. The purpose of this study was to assess the performance of sepsis-induced coagulopathy (SIC), the Japanese Association for Acute Medicine Disseminated Intravascular Coagulation (JAAM DIC), and the International Society on Thrombosis and Haemostasis overt DIC (ISTH overt-DIC). The relationship between each scoring system and 28-day all-cause mortality was examined. Among 452 patients (mean age, 65 [48,76] years), 306 [66.7%] were men, the median SOFA score was 6 [4,9], and the median APACHE II score was 15 [11,22]. A total of 132 patients (29.2%) died within 28 days. Both the diagnosis of SIC (AUROC, 0.779 [95% CI, 0.728–0.830], P < 0.001) and ISTH overt-DIC (AUROC, 0.782 [95% CI, 0.732–0.833], P < 0.001) performed equally well in the discrimination of 28-day all-cause mortality (between-group difference: SIC versus ISTH overt-DIC, −0.003 [95% CI, −0.025–0.018], P = 0.766). However, the SIC demonstrated greater calibration for 28-day all-cause mortality than ISTH overt-DIC (the coincidence of the calibration curve of the former is higher than that of the latter). The diagnosis of JAAM DIC was not independently associated with 28-day all-cause mortality in sepsis (RR, 1.115, [95% CI 0.660–1.182], P = 0.684). The SIC scoring system demonstrated superior prognostic prediction ability in comparison with the others and is the most appropriate standard for diagnosing coagulopathy in sepsis.
Optimization of the Tracking Beam Sequence in Harmonic Motion Imaging

Harmonic motion imaging (HMI) is an ultrasound elastography technique that estimates the viscoelastic properties of tissues by inducing localized oscillatory motion using focused ultrasound (FUS). The resulting displacement, assumed to be inversely proportional to the tissue local stiffness, is estimated using an imaging array based on RF speckle tracking. In conventional HMI, this is accomplished with plane-wave (PW) imaging, which inherently suffers from low lateral resolution. Coherent PW compounding (PWC) leverages spatial and temporal resolution using synthetic focusing in transmit. In this study, we introduced focused imaging with parallel tracking in HMI and compared parallel tracking of various transmit F-numbers (F/2.6, 3, 4, and 5) qualitatively and quantitatively with PW and PWC imaging at various compounded angle ranges (6°, 12°, and 18°). An in silico model of a 56-kPa spherical inclusion (diameter: 3.6 mm) embedded in a 5.3-kPa background and a 5.3-kPa elastic phantom with cylindrical inclusions (Young’s moduli: 22–56 kPa, diameters: 2.0–8.6 mm) were imaged to assess different tracking beam sequences. Speckle biasing in displacement estimation associated with parallel tracking was also investigated and concluded to be negligible in HMI. Parallel tracking in receive (Rx) resulted in 2%–7% and 8%–12% increase compared to PW imaging ( ${p}< {0.05}$ ) in HMI contrast and contrast-to-noise ratio in silico and phantoms. Focused imaging with parallel tracking in Rx was concluded to be most robust among PW and PWC imaging for displacement estimation, and its preclinical feasibility was demonstrated in postsurgical human cancerous breast tissue specimens and in vivo murine models of breast cancer.
Equivalent images derived from very-low-frequency (VLF) profile data

We describe the implementation of a new fast imaging technique for filtering very-low-frequency (VLF) data measured on profiles into corresponding equivalent current systems in the earth. Single-frequency VLF data using magnetic measurements alone are often used to delineate lateral changes in electrical conductivity, e.g., fracture zones in crystalline terrains or changes in lithology in the sedimentary cover. Here, an attempt is made to add depth information to the conductivity distribution by realizing that the single-frequency VLF profile data contain information about (1) the background medium through their decay away from the conductors, (2) the position, and (3) the depth of the dominating conductors through the relative contribution of in-phase and quadrature components to the VLF anomaly in addition to the rate of change of the anomaly close to the conductors. Synthetic data from a model containing a shallow and a deeper conductor are filtered to show that the estimated current distributions coincide well with the horizontal position of the conductors, but even they provide some smeared images of the depth distribution of the conductors. A comparison with models obtained from regularized inversion of the same data shows good correspondence. The VLF field data from an area with clay lenses overlying wet sand and crystalline basement are filtered into current distributions that grossly mimic the electrical conductivity distribution of the clay lenses as obtained from radiomagnetotelluric measurements along the same profile.
Transport of Sand and Partly Cohesive Sediments in a Circular Pipe Run Partially Full

Many sediment deposits contain not only a granular but also a mineral and/or organic cohesive fraction, which has the potential to change significantly the erosion response when compared to noncohesive sediment deposits. Sediment deposits containing a low proportion of cohesive sediment display a specific, transitional behavior between cohesive and noncohesive sediments. In the past, several studies have examined partly cohesive sediment, however, the quantification of its erosion behavior is still unsatisfactory. In an attempt to advance the understanding and qualitative description of erosion and transport of mixed sediments in pipes, a comprehensive experimental investigation on the erosion behavior was designed. Tests were conducted in a flume with semicircular cross section with a diameter of 0.39 m using fine sand with a d50 =0.19 mm and partly cohesive sediment deposits being a mixture of sand and clay with proportion of 3–10% by weight of clay. Tests covered a range of flow conditions with Froude .