Miracle-dz/UniFAR-FTUs huggingface dataset:
Problems Faced By Maize Growers of Udaipur District

The study was conducted in four villages of three Panchayat Samities of Udaipur district by personal interviewing 80 trained and 80 untrained maize growers. Ecological constraints were the major constraints perceived by the maize growers followed by post-harvest technology, plant protection measures, marketing problems, chemical control of weeds, soil treatment and fertilizer application, method of sowing, seed rate and time of sowing, seed treatment and improved seed. At overall level, constraints faced by the trained respondents were less as compared with untrained respondents. KVK. , Udaipur should arrange training programmes to reduce the gap and other concerned agencies should also take action in this regard.
Adrenal and Gonadal Activity, Androgen Concentrations, and Adult Height Outcomes in Boys With Silver-Russell Syndrome

Background: We have previously shown that adult height (AH) in males with Silver-Russell syndrome (SRS) correlated negatively with prepubertal estradiol concentrations. We aimed to identify the source of estradiol by analyzing androgen secretion profiles and measuring anti-Müllerian hormone (AMH) and inhibin B concentrations during childhood and puberty in this group of patients. Methods: In a retrospective longitudinal single-center study, 13 males with SRS were classified as non-responders (NRs = 8) or responders (Rs = 5), depending on the AH outcome. From 6 years of age, androgens were determined by mass spectrometry, and AMH, inhibin B and sex hormone-binding globulin concentrations were analyzed by immunoassays. Results: AH outcome correlated negatively with dehydroepiandrosterone-sulfate (DHEAS) at 8 (r = −0.72), 10 (r = −0.79), and 12 years (r = −0.72); testosterone at 10 (r = −0.94), 12 (r = −0.70) and 14 years (r = −0.64); dihydrotestosterone (DHT) at 10 (r = −0.62) and 12 years; (r = −0.57) and AMH at 12 years (r = 0.62) of age. Compared with Rs, NRs had higher median concentrations of DHEAS (μmol/L) at 10 years (2.9 vs. 1.0); androstenedione (nmol/L) at 10 (1.1 vs. 0.6) and 12 years (1.7 vs. 0.8); testosterone (nmol/L) at 10 (0.3 vs. 0.1), 12 (7.8 vs. 0.2) and 14 years (15.6 vs. 10.4); and DHT (pmol/L) at 10 (122 vs. 28) and 12 years (652 vs. 59) of age. AMH (ng/mL) was lower in NRs than in Rs at 12 years of age (11 vs. 50). No significant differences were observed in the inhibin B concentrations at any age. Conclusions: The elevated androgen concentrations before and during puberty, originated from both adrenal and gonadal secretion and correlated negatively with AH outcomes in males with SRS.
Label-free sensing of cells with fluorescence lifetime imaging: The quest for metabolic heterogeneity

Molecular, morphological and physiological heterogeneity is the inherent property of cells, which governs differences in their response to external influence. The tumor cells metabolic heterogeneity is of a special interest due to its clinical relevance to the tumor progression and therapeutic outcomes. Rapid, sensitive and non-invasive assessment of metabolic heterogeneity of cells is of a great demand for biomedical sciences. Fluorescence lifetime imaging (FLIM), which is an all-optical technique is an emerging tool for sensing and quantifying cellular metabolism by measuring fluorescence decay parameters (FDPs) of endogenous fluorophores, such as NAD(P)H. To achieve the accurate discrimination between metabolically diverse cellular subpopulations, appropriate approaches to FLIM data collection and analysis are needed. In this report, the unique capability of FLIM to attain the overarching goal of discriminating metabolic heterogeneity has been demonstrated. This has been achieved using a novel approach to data analysis based on the non-parametric analysis, which revealed a much better sensitivity to the presence of metabolically distinct subpopulations as compare more traditional approaches of FLIM measurements and analysis. The new approach was further validated for imaging cultured cancer cells treated with chemotherapy. Those results pave the way for an accurate detection and quantification of cellular metabolic heterogeneity using FLIM, which will be valuable for assessing therapeutic vulnerabilities and predicting clinical outcomes.
Lifestyle Behaviors and Parents’ Mental Well-Being Among Low-Income Families During COVID-19 Pandemic

Background The coronavirus 2019 (COVID-19) pandemic has negatively altered many families’ lifestyles and the mental well-being of parents, especially those who have a low income and young children. To improve low-income parents’ mental well-being, especially during a pandemic, understanding parents’ and children’s lifestyle behaviors and the relationship between their lifestyle behaviors and parents’ mental well-being is essential. Objective This cross-sectional study examined relationships between lifestyle behaviors (sleep, physical activity, screen time, and eating behavior of parents and children) and low-income parents’ well-being (stress, anxiety, and depression) during COVID-19. Methods Parents were recruited from two Michigan Head Start organizations as well as across the United States; 408 parents completed an online survey. Demographic characteristics were assessed, along with parents’ sleep, physical activity, screen time, and dietary intake; stress, anxiety, and depression were also examined. Children’s sleep time, physical activity, screen time, and fruit/vegetable intake were assessed. Descriptive statistics, correlations, and the multivariate general linear model procedure were used. Results Approximately 69.4% of parents reported moderate stress levels, and 17.2% reported high levels. Most parents had sleep disturbances, attained minimal physical activity, and consumed <5 fruits/vegetables per day; average screen time was >2 hours per day. Only 41% of preschoolers were active 7 days a week and slept ≥10 hours per day. Two thirds had >2 hours per day of screen time, and less than one fifth consumed ≥5 fruits/vegetables per day. After adjusting for parents’ demographics and children’s lifestyle behaviors, parents’ sleep disturbance was positively correlated with their levels of stress, anxiety, and depression. After controlling for parents’ demographics and lifestyle behaviors, child sleep time was negatively associated with parents’ stress levels. Family demographics and parents’ and children’s lifestyle behaviors explained 33.4%, 29.8%, and 28.1% of the variances in parents’ stress, anxiety, and depression, respectively. Discussion Most parents and preschoolers were not meeting many lifestyle behavior recommendations, indicating a need for interventions. Improving parents’ sleep quality and reducing bedtime challenges involving their preschoolers may be necessary for enhancing parental mental well-being.
Analyzing the Time-Varying Thermal Perception of Students in Classrooms and Its Influencing Factors from a Case Study in Xi’an, China

Owing to movement in the spatial environment and changes in activity levels, students’ thermal perception is time varying in classrooms throughout different periods of the day. However, previous studies have rarely considered the time-varying thermal perception in different periods of the day, which may cause discomfort for students and lead to energy wastage. Therefore, a study was conducted to investigate the time-varying thermal perception of students and its influencing factors in different classes of the day. In addition, the differences in students’ adaptive behaviors in different periods were also explored. A total of 578 university students were surveyed using questionnaire surveys during the heating season in Xi’an, China. The following results can be obtained: (1) The thermal sensation vote and thermal preference vote values in the afternoon were significantly higher than those in the morning. At the start of the first class in the morning/afternoon, the thermal sensation of the students had the highest sensitivity to outdoor temperature changes. (2) The students’ thermal perception was greatly affected by the preclass activity state at the start of the first class in the morning/afternoon. However, in other periods, the above phenomenon was not obvious. (3) In the afternoon, the frequency of clothing adjustment was greater than that in the morning, and this behavior would significantly affect the students’ thermal sensation. (4) Compared with the current classroom heating strategy, the heating strategy of dynamically adjusting the indoor set temperature according to the time-varying characteristics of the students can theoretically achieve energy savings of 25.6%.
Changes in Electroencephalographic Results and Heart Rate Variability after Exposure to Green Landscape Photographs Correlated with Color Temperature and Illumination Level

Background and objective: Various images from visual display terminals (VDTs) as well as living lighting are important parts of our daily life; thus, properly controlling the lighting environment – that is, illuminance, color temperature and good images from VDTs – can have a substantial effect on improving the mental health and work efficiency in everyday life. We examined electroencephalography (EEG) and heart rate variability (HRV) responses to various lighting conditions in 25 university students as they viewed images of a green landscape or traffic congestion.Methods: EEG was performed in darkness and when the room was illuminated with 10 different light-emitting diode (LED) color temperatures, while the EEG and HRV responses to green landscape or traffic congestion image stimuli were measured in darkness and during room illumination with three different LED color temperatures.Results: We found a significant difference between darkness and high LED illumination (400 lx) at 7 (CZ, F4, FZ, O1, O2, OZ, and T6) of 30 channels, while the alpha wave activity increased during darkness. In the second experiment, the green landscape image stimuli in the 30 lx–2600 K lighting condition elicited theta wave activity on the EEG, whereas the traffic congestion image stimuli under high LED illumination elicited high beta and gamma wave activities. Moreover, the subjects exhibited better stress coping ability and heart rate stability in response to green landscape image stimuli under illuminated conditions, according to their HRV.Conclusion: These results suggest that lower color temperatures and illumination levels alleviate tension, and that viewing green landscape image stimuli at low illumination, or in darkness, is effective for reducing stress. Conversely, high illumination levels and color temperatures are likely to increase tension and stress in response to traffic congestion image stimuli.
Influence of Broiler Age on the Apparent Metabolizable Energy of Cereal Grains Determined Using the Substitution Method

Simple Summary Knowledge of the metabolizable energy content of cereal grains is critical for their economical and sustainable use and precise poultry feed formulation. The current practice in the feed industry is to use the apparent metabolizable energy (AME) or nitrogen-corrected AME (AMEn) values of ingredients from prediction equations or reference tables, which have been estimated using (5-week-old birds). Several factors, including age, ingredient type, and methodology, can affect the AMEn value of ingredients in poultry. Currently, there are no data available on the age effect, from hatch to 6 weeks of age, on the AMEn of grains in broilers. The aim of the present study was to investigate the influence of age on the AMEn of wheat, sorghum, barley, and corn from hatching to day 42 using the substitution method. The results showed that the age influence on the AMEn of cereal grains was grain dependent. In wheat and sorghum, AMEn was influenced by age, while the AMEn of barley and corn were unaffected. Poultry nutritionists might need to consider age-dependent AME or AMEn values for some grains in feed formulations. Abstract The present study investigated the influence of broiler age on the AMEn of wheat, sorghum, barley, and corn using the substitution method at six different ages (days 7, 14, 21, 28, 35, and 42). A corn-soybean meal basal diet was formulated and, the test diets were developed by replacing (w/w) 300 g/kg of the basal diet with wheat, sorghum, barley, or corn. Bird age influenced (p < 0.001) the AMEn of wheat and sorghum but had no effect (p > 0.05) on those of barley and corn. The AMEn of wheat increased with age (p < 0.001) from 12.53 MJ/kg DM in week 1 to 14.55 MJ/kg DM in week 2, then declined subsequently, but no linear or quadratic responses were observed. The AMEn of sorghum demonstrated a quadratic response (p < 0.05), increasing from 12.84 MJ/kg DM in week 1 to 13.95 MJ/kg DM in week 2, and then plateauing to week 6. Overall, the present results suggest that the effect of broiler age on the AMEn varies depending on the grain type. The current data suggest that the application of age-dependent AME or AMEn of wheat and sorghum will lead to more precise feed formulations.
Bridging Transcriptome Regulation and Cellular Operational Efficiency with the Locality and Caching System Optimization Principles

Gene expression is time-consuming and sequentially more so from bacteria to yeast to human, rendering human cells vulnerable to proteomic-response and operational latency. Computers once suffered such latency, imposed by much-slower information retrieval (hard-drive (HD) to memory to central-processing-unit (CPU)) than CPU execution. Optimization principles, namely, spatiotemporal-locality-principles that control specialized user-programs and caching that controls operating system (OS) kernel (the HD-CPU information flow channel), successfully mitigated the latency by gearing the memory towards near-future or high-priority CPU needs. We report evidence that the principles similarly act in cellular latency-mitigation via analogizing genome-mRNA-protein gene-expression to HD-memory-CPU information-retrieval, and transcriptome to memory. First, temporal-locality-principle is equivalent to mRNA stabilization-by-translation regulation and controls specialized cellular functions. Second, caching is equivalent to cytoplasmic mRNA sequestration. Highly sequestered mRNAs defy the locality-principle. In both cells and computers, caching controls the information channels; gene expression machinery and their regulators, i.e., the cellular channel (OS-kernel equivalent) that regulates arguably all cellular processes, are top sequestered mRNAs. Third, mRNA-caching contributes to the mRNA-protein expression discrepancy. Thus, locality and caching principles control specialized and core cellular functions, respectively, orchestrating transcriptome regulation and bridging it to cellular operational efficiency.
The best indicator of hydraulic short-circuiting and mixing of constructed wetlands

Hydraulic residence time (HRT) distribution intuitively reflects flow pattern of constructed wetlands. HRT is able to reflect the merits of flow state clearly. Short-circuiting and mixing are the most important factors on HRT, exerting a significant effect on the flow pattern of wetlands. These two conditions must be avoided in wetlands construction and management. Therefore, it is necessary to select the best indicators measuring short-circuiting and mixing for understanding the flow pattern and the hydraulic performance of wetlands. This paper analyzes numerous indicators reflecting the degree of short-circuiting and mixing, displaying that t 10 and Morril index t 90 / t 10 are optimal indicators measuring short-circuiting and mixing, respectively, according to truncation and stability analysis based on tracer data. Data analysis showed that when water depth dropped, t 10 increased and t 90 / t 10 reduced gradually, indicating the improvement of short-circuiting and mixing. These results were fully consistent with the analysis results of hydraulic parameters, such as effective volume ratio e and the number of serial mixing tanks N . The excellent indicators of short-circuiting and mixing provide theoretical basis for reasonable design and evaluation of constructed wetlands, contributing to promote the hydraulic performance and purification effect.
Heritable and climatic sources of variation in juvenile tree growth in an Austrian common garden experiment of Central European Norway spruce populations

We leveraged publicly available data on juvenile tree height of 299 Central European Norway spruce populations grown in a common garden experiment across 24 diverse trial locations in Austria and weather data from the trial locations and population provenances to parse the heritable and climatic components of juvenile tree height variation. Principal component analysis of geospatial and weather variables demonstrated high interannual variation among trial environments, largely driven by differences in precipitation, and separation of population provenances based on altitude, temperature, and snowfall. Tree height was highly heritable and modeling the covariance between populations and trial environments based on climatic data led to more stable estimation of heritability and population × environment variance. Climatic similarity among population provenances was highly predictive of population × environment estimates for tree height.
In Vivo Evaluation of 6 Analogs of 11C-ER176 as Candidate 18F-Labeled Radioligands for 18-kDa Translocator Protein

Visual Abstract Because of its excellent ratio of specific to nondisplaceable uptake, the radioligand 11C-ER176 can successfully image 18-kDa translocator protein (TSPO), a biomarker of inflammation, in the human brain and accurately quantify target density in homozygous low-affinity binders. Our laboratory sought to develop an 18F-labeled TSPO PET radioligand based on ER176 with the potential for broader distribution. This study used generic 11C labeling and in vivo performance in the monkey brain to select the most promising among 6 fluorine-containing analogs of ER176 for subsequent labeling with longer-lived 18F. Methods: Six fluorine-containing analogs of ER176—3 fluoro and 3 trifluoromethyl isomers—were synthesized and labeled by 11C methylation at the secondary amide group of the respective N-desmethyl precursor. PET imaging of the monkey brain was performed at baseline and after blockade by N-butan-2-yl-1-(2-chlorophenyl)-N-methylisoquinoline-3-carboxamide (PK11195). Uptake was quantified using radiometabolite-corrected arterial input function. The 6 candidate radioligands were ranked for performance on the basis of 2 in vivo criteria: the ratio of specific to nondisplaceable uptake (i.e., nondisplaceable binding potential [BPND]) and the time stability of total distribution volume (VT), an indirect measure of lack of radiometabolite accumulation in the brain. Results: Total TSPO binding was quantified as VT corrected for plasma free fraction (VT/fP) using Logan graphical analysis for all 6 radioligands. VT/fP was generally high at baseline (222 ± 178 mL·cm−3) and decreased by 70%–90% after preblocking with PK11195. BPND calculated using the Lassen plot was 9.6 ± 3.8; the o-fluoro radioligand exhibited the highest BPND (12.1), followed by the m-trifluoromethyl (11.7) and m-fluoro (8.1) radioligands. For all 6 radioligands, VT reached 90% of the terminal 120-min values by 70 min and remained relatively stable thereafter, with excellent identifiability (SEs < 5%), suggesting that no significant radiometabolites accumulated in the brain. Conclusion: All 6 radioligands had good BPND and good time stability of VT. Among them, the o-fluoro, m-trifluoromethyl, and m-fluoro compounds were the 3 best candidates for development as radioligands with an 18F label.
Interaction between Phrasal Structure and Vowel Tenseness in German: An Acoustic and Articulatory Study

Phrase-final lengthening affects the segments preceding a prosodic boundary. This prosodic variation is generally assumed to be independent of the phonemic identity. We refer to this as the ‘uniform lengthening hypothesis’ (ULH). However, in German, lax vowels do not undergo lengthening for word stress or shortening for increased speech rate, indicating that temporal properties might interact with phonemic identity. We test the ULH by comparing the effect of the boundary on acoustic and kinematic measures for tense and lax vowels and several coda consonants. We further examine if the boundary effect decreases with distance from the boundary. Ten native speakers of German were recorded by means of electromagnetic articulography (EMA) while reading sentences that contained six minimal pairs varying in vowel tenseness and boundary type. In line with the ULH, the results show that the acoustic durations of lax vowels are lengthened phrase-finally, similarly to tense vowels. We find that acoustic lengthening is stronger the closer the segments are to the boundary. Articulatory parameters of the closing movements toward the post-vocalic consonants are affected by both phrasal position and identity of the preceding vowel. The results are discussed with regard to the interaction between prosodic structure and vowel tenseness.
Effects of Resistance Training Cessation on Cycling Performance in Well-Trained Cyclists: An Exploratory Study

Abstract Bláfoss, R, Rikardo, J, Andersen, AØ, Hvid, LG, Andersen, LL, Jensen, K, Christensen, PM, Kvorning, T, and Aagaard, P. Effects of resistance training cessation on cycling performance in well-trained cyclists: an exploratory study. J Strength Cond Res 36(3): 796–804, 2022—Supplementary (i.e., concurrent) resistance training can enhance cycling performance among competitive cyclists. However, a lack of knowledge exists about the retention (decay profile) in mechanical muscle function and cycling performance after concurrent resistance and endurance training. The present exploratory intervention study investigated the effect of 6 weeks of resistance training cessation when preceded by 8 weeks of concurrent resistance and endurance training on mechanical muscle function and cycling performance in 9 male well-trained competitive cyclists (V̇o2max = 66 ± 7 ml·min−1·kg−1). Cyclists performed periodized resistance training targeting leg and core muscles for 8 weeks as a supplement to their normal endurance (cycling) training. This was followed by 6 weeks of endurance training only (retention period) leading up to the start of the competitive season. Maximal leg extensor power, isometric leg extensor strength (maximal voluntary contraction [MVC]), rate of force development (RFD), and long-term cycling performance (2-hour submaximal cycling at 55% of Wmax), followed by 5-minute max cycling were evaluated. After 8 weeks of concurrent resistance and endurance training, leg extensor power, MVC, and RFD increased by 12, 15, and 17%, respectively while mean power output (W) during 5-minute max cycling increased by 7% (p < 0.05). Training-induced gains in MVC and 5-minute max cycling power were retained after 6-week cessation of resistance training (p < 0.05). These findings indicate that competitive cyclists can focus on cycling training alone for at least 6 weeks leading up to competition without losing attained gains in maximal muscle strength and cycling performance achieved by preceding periods of concurrent resistance training.