Miracle-dz/UniFAR-FTUs huggingface dataset:
A Monte Carlo Study: The Impact of Missing Data in Cross-Classification Random Effects Models

A MONTE CARLO STUDY: THE IMPACT OF MISSING DATA IN CROSS-CLASSIFICATION RANDOM EFFECTS MODELS by Meltem Alemdar Unlike multilevel data with a purely nested structure, data that are cross-classified not only may be clustered into hierarchically ordered units but also may belong to more than one unit at a given level of a hierarchy. In a cross-classified design, students at a given school might be from several different neighborhoods and one neighborhood might have students who attend a number of different schools. In this type of scenario, schools and neighborhoods are considered to be cross-classified factors, and cross-classified random effects modeling (CCREM) should be used to analyze these data appropriately. A common problem in any type of multilevel analysis is the presence of missing data at any given level. There has been little research conducted in the multilevel literature about the impact of missing data, and none in the area of cross-classified models. The purpose of this study was to examine the effect of data that are missing completely at random (MCAR), missing at random (MAR), and missing not at random (MNAR), on CCREM estimates while exploring multiple imputation to handle the missing data. In addition, this study examined the impact of including an auxiliary variable that is correlated with the variable with missingness (the level-1 predictor) in the imputation model for multiple imputation. This study expanded on the CCREM Monte Carlo simulation work of Meyers (2004) by the inclusion of studying the effect of missing data and method for handling these missing data with CCREM. The results demonstrated that in general, multiple imputation met Hoogland and Boomsma’s (1998) relative bias estimation criteria (less than 5% in magnitude) for parameter estimates under different types of missing data patterns. For the standard error estimates, substantial relative bias (defined by Hoogland and Boomsma as greater than 10%) was found in some conditions. When multiple imputation was used to handle the missing data then substantial bias was found in the standard errors in most cells where data were MNAR. This bias increased as a function of the percentage of missing data. A MONTE CARLO STUDY: THE IMPACT OF MISSING DATA IN CROSS-CLASSIFICATION RANDOM EFFECTS MODELS by Meltem Alemdar
Combining active learning and relevance vector machines for text classification

Relevance vector machines (RVM) have proven successful in many learning tasks. However, in large applications, they scale poorly. In many settings there is a large amount of unlabeled data which could be actively chosen by a learner and integrated in the learning procedure. The idea is to improve performance meanwhile reducing costs from data categorization. In this paper we propose an active learning RVM method based on the kernel trick. The underpinning idea is to define a working space between the relevance vectors (RV) initially obtained in a small labeled data set and the new unlabeled examples, where the most informative instances are chosen. By using kernel distance metrics, such a space can be defined and more informative examples can be added to the training set, increasing performance even though the problem dimension is not significantly affected. We detail the proposed method giving illustrative examples in the Reuters-21578 benchmark. Results show performance improvement and scalability.
Preview : Published ahead of advance online publication Insane in the membrane : a structural perspective of MLKL function in necroptosis

This is a PDF file of an unedited peer-reviewed manuscript that has been accepted for publication. NPG are providing this early version of the manuscript as a service to our customers. The manuscript will undergo copyediting, typesetting and a proof review before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers apply.
Supplemental Material for “A Model Framework for Simulating Spatial Hearing of Bilateral Cochlear Implants Users”

In order to show some possible applications of the presented framework, four experiments are 13 presented in this supplementary document. We feel that using the model “as is” may serve as a useful 14 starting point and should be reported in some form. It is, however, not suitable for a single 15 manuscript to cover all this information and not always in our capacity to simulate all types in the 16 most meaningful and verified manner to meet our own expectations for the main part of a scientific 17 publication. Therefore, we decided to report them in the present format. 18
Organogenesis and Distribution of the Ocular Lymphatic Vessels in the Anterior Eye: Implication to Glaucoma Surgery Site Selection

Glaucoma surgeries, such as trabeculectomy, are performed to lower the intraocular pressure to reduce the risk of vision loss. The surgeries create a new passage in the eye that reroutes the aqueous humor outflow to the subconjunctival space, where the fluid is presumably absorbed by the conjunctival lymphatics. However, the current knowledge of these ocular surface lymphatics remains limited. Here, we characterized the biology and function of the ocular lymphatics using transgenic lymphatic reporter mice and rats. We found that the limbal and conjunctival lymphatic networks are progressively formed by a primary lymphatic vessel that grows out from the nasal-side medial canthus region at the time of birth. This primary lymphatic vessel immediately branches out and invades the limbus and conjunctiva, and then simultaneously encircles the cornea in a bidirectional manner. As a result, the distribution of the ocular lymphatic is significantly polarized toward the nasal side, and the limbal lymphatics are directly connected to the conjunctival lymphatics. New lymphatic spouts are mainly produced from the nasal-side limbal lymphatics, posing the nasal side of the eye more responsive to fluid drainage and inflammatory stimuli. Consistently, when a fluorescent tracer was injected, fluid clearance was much more efficient in the nasal side than the temporal side of the eyes. In comparison, blood vessels are evenly distributed on the front surface of the eyes. We found that these distinct vascular distribution patterns were also conserved in human eyes. Together, our study demonstrated that the ocular surface lymphatics are more densely present in the nasal side and uncovered the potential clinical benefits in selecting the nasal side as a surgical site for glaucoma surgeries to improve the fluid drainage.
PLATELETS AND THROMBOPOIESIS Platelet-derived ERp57 mediates platelet incorporation into a growing thrombus by regulation of the a IIb b 3 integrin

defective activation of the a IIb b 3 integrin and plateletaggregation.Thedefectinaggregationwascorrectedbytheadditionofexogenous ERp57, implicating surface ERp57 in platelet aggregation. Using mutants of ERp57, we demonstrate the second active site targets a platelet surface substrate to potentiate platelet aggregation. Binding of Alexa 488 2 labeled ERp57 to thrombin-activated and Mn 2 1 -treated platelets lacking b 3 was decreased substantially, suggesting a direct interaction of ERp57 with a IIb b 3. Surface expression of ERp57 protein and activity in human platelets increased with platelet activation, with protein expressionoccurringinaphysiologicallyrelevanttimeframe.Inconclusion,platelet-derivedERp57directlyinteractswith a IIb b 3during activation of this receptor and is required for incorporation of platelets into a growing thrombus. ( Blood . 2013;122(22):3642-3650)
FACTORS INFLUENCING CLOUD COMPUTING ADOPTION IN SMALL AND MEDIUM ENTERPRISES

Cloud computing offers information technology (IT) infrastructure, platform, and various applications via the Internet with minimum start-up cost, network access to a shared pool of configurable computing resources, and pay-per-use services. Although the potential for cloud computing is evident and much of the extant research has been carried out on cloud computing adoption, empirical studies on the factors that influence cloud computing adoption in the Malaysian Small and Medium Enterprises (SMEs) are, however, lacking. The objective of this study was to examine the factors that influence cloud computing adoption by the SMEs. We conducted a quantitative survey-based study to examine the relationship between perceived benefits, top management support, IT resources, external pressure, and cloud computing adoption. A free-form comment provided at the end of each section of the survey questionnaire was treated as qualitative data. We find that IT resources and external pressure significantly influence cloud computing adoption. Nonetheless, there is not enough evidence to support perceived benefits and top management support as significant factors of cloud computing adoption.
Analisis pencemaran logam berat Cu, Cd dan Pb di perairan kabupaten administrasi kepulauan seribu provinsi daerah khusus ibukota Jakarta (Studi kasus pulau panggang dan pulau pramuka)

HARRY SUDRADJAT JOHARI. Contamination Analysis of Heavy Metal Cu, Cd and Pb in the waters of Kepulauan Seribu Regency, Jakarta Province (Bakeout Island Case Study and Pulau Pramuka). Guided by ETTY RIANI and RUDHY GUSTIANO. Research on the contamination of heavy metals in the waters of Kepulauan Seribu Regency, Jakarta Province, was done using four observed components : sea water, sediment, coloured rasor shell (Pinna muricata) and milkfish (Chanos chanos). Heavy metals examined were copper (Cu), cadmium (Cd) and lead (Pb) in ten sampling sites. Method used in the heavy metals analysis were Indonesian National Standart (SNI) using atomic absorption spectrofotometry (AAS), regresion analysis were then applied on the collected data to understand the relationship among the component studied. The results showed that the concentration of heavy metals Cu, Cd and Pb in sea water as follow 0,0017 -0,0041 mg/l, 0,0014-0,0040 mg/l, 0,0062-0,0074 mg/l. Meanwhile in sediment, they were 0,3878-6,4345 mg/kg, 0,1536-3,0244 mg/kg, 0,4260-1,5770 mg/kg. Among three metals observed only Cu was not exist in coloured rasor shell and milkfish. The concentration of Cd in shell and fish following order were 0,0043-0,0090 mg/kg, and 0,0087-0,0147 mg/kg, for Pb, it was 0,0043 – 0,0890 mg/kg, in shell an 0,053-0,0127 mg/kg in fish. Regression analysis clarified that concentration heavy metals in sea water and sediment has tigh relationship in contrast, there were tight relationship between heavy metals in sea water and biotic organism (shell and fish). Keyword : Heavy metal, sea water, shell (Pinna muricata), milkfish (Chanos chanos), Kepulauan Seribu Jakarta.
The Effect of Aluminium on Deformation and Twinning in Alpha Titanium: The 45° Case

The deformation behaviour of binary Ti-Al model alloys has been observed in respect to nucleation, propagation and growth of twins, specifically the interaction of slip and {1 0 -1 2} tensile twins. The area fraction of twins increases by trend from Ti-0Al to Ti-4Al but significantly reduces to Ti-6Al. The lattice strain evolution during compression was measured using in-situ neutron diffraction and decreases from Ti-0Al to Ti-4Al but increases to Ti-6Al. The twin activity in hcp Ti behaves as expected from fcc materials until 4 wt. % Al concentration, but it is believed that short or long range ordering reduces the twin activity in Ti-6Al.
Inflammation-mediated rheumatic diseases and atherosclerosis

For over 20 years, premature coronary heart disease has been recognised as a major determinant of morbidity and mortality in patients with systemic lupus erythematosus (SLE). 1-4 Less appreciated is the fact that the same holds true for patients with rheumatoid arthritis (RA). 5-7 These two autoimmune diseases share a propensity to target women of childbearing age and a treatment armamentarium that includes corticosteroids and other immunosuppressive agents. Despite clear distinctions in pathophysiology, the immune dysfunction unique to each disease results in a chronic inflammatory state, which may have implications for the atherogenesis seen in these young patients. As we compare and contrast potential cardiovascular risk factors in these two autoimmune diseases, we may further our understanding of why these young women are at high risk for premature atherosclerosis. Women with SLE have a high incidence of coronary heart disease.1-4 Several investigators have convincingly shown that women with SLE under the age of 45 are at substantially increased risk of ischaemic heart disease.1 4 We reported that women with SLE aged 35–44 were over 50 times more likely to have a myocardial infarction than were women of similar age from a population based sample (rate ratio = 52.43, 95% CI 21.6 to 98.5). 1In contrast, women with SLE in the 45–64 year age group were only two to four times more likely to have a myocardial infarction than women without SLE of the same age. We also found a small decline in the incidence rates for myocardial infarction in women with SLE aged 45–54 compared with those having the same diagnosis aged 35–44. The reasons for this are unclear. A difference in overall survival is an unlikely explanation as mortality rates from all causes were not significantly different between women in these two age strata. A plausible …
Hydrothermal cooling along the Eastern Lau Spreading Center: No evidence for discharge beyond the neovolcanic zone

Heat transported from the mantle beneath spreading centers creates an astonishingly narrow ribbon of convective heat discharge at plate boundaries, as apparently demonstrated by exhaustive exploration for hydrothermal discharge sites over the last three decades. Recent observations and models are now challenging this assumption of exclusively axis‐centric high‐temperature venting. One example is the proposal that intense cooling along the vertical boundaries of a broad low‐velocity volume (LVV) of hot crust could generate high‐temperature fluids several kilometers off axis. To test the hypothesis that substantial hydrothermal discharge might occur beyond the LVV, we conducted a dense survey grid of the ridge and surrounding seafloor (up to ±5 km) along 175 km of the Eastern Lau Spreading Center and Valu Fa Ridge (∼1800 km of track line). Our sampling array extended from ∼50 to 400 m above bottom and included light‐scattering, oxidation‐reduction potential, and hydrographic sensors attached to the tow line and beneath the IMI120 sonar mapping system. The surveys successfully mapped plumes from several vent fields in the neovolcanic zone (∼±1.5 km about the axis) but did not detect evidence of significant discharge anywhere farther off‐axis. At a few locations on the Valu Fa Ridge, however, we did record oxidation‐reduction potential anomalies with hydrographic density signatures that imply low‐temperature hydrothermal sources on the axial flank. Although these sites are hundreds of meters deeper than the adjacent crest, they are above, not beyond, the previously mapped LVV. Our results thus do not support a simple picture of high‐temperature fluids ascending undiluted through the crust to the seafloor several kilometers off‐axis. However, we cannot exclude the possibilities that the largely unmapped LVV is narrower here than seen on other ridges, that hydrothermal fluids formed beyond the LVV are channeled to the axis, or that discharge beyond the neovolcanic zone occurs only as dispersed, very low‐temperature fluids. Our observations do demonstrate that high‐temperature discharge predominantly exits the seafloor within a narrow (∼±1.5 km) axial ribbon, regardless of the presence or absence of an axial magma chamber.
Maternal Supplementation of Vitamin E or Its Combination with Hydroxytyrosol Increases the Gut Health and Short Chain Fatty Acids of Piglets at Weaning

An adequate intestinal environment before weaning may contribute to diarrhea predisposition and piglet development. This study evaluates how the dietary supplementation of vitamin E (VE) (100 mg/kg), hydroxytyrosol (HXT) (1.5 mg/kg) or the combined administration (VE + HXT) given to Iberian sows from gestation affects the piglet’s faecal characteristics, short chain fatty acids (SCFAs), fatty acid profile or intestinal morphology as indicators of gut health; and quantify the contribution of the oxidative status and colostrum/milk composition to the piglet’s SCFAs content and intestinal health. Dietary VE increased isobutyric acid (iC4), butyric acid (C4), isovaleric acid (iC5), and ∑SCFAs, whereas HXT increased iC4 and tended to decrease ∑SCFAs of faeces. Piglets from HXT-supplemented sows also tended to have higher faecal C20:4n-6/C20:2 ratio C22:6 proportion and showed lower occludin gene expression in the duodenum. The combination of both antioxidants had a positive effect on iC4 and iC5 levels. Correlation analyses and regression equations indicate that faecal SCFAs were related to oxidative status (mainly plasma VE) and colostrum and milk composition (mainly C20:2, C20:3, C20:4 n-6). This study would confirm the superiority of VE over HXT supplementation to improve intestinal homeostasis, gut health, and, consequently piglet growth.
Spatial Characteristics and Driving Forces of the Water Footprint of Spring Maize Production in Northern China

Using the water footprint (WF) approach to evaluate the water-use efficiency in agricultural production is crucial for assessing the sustainable use of water resources and mitigating water scarcity and pollution. This study calculated the blue, grey, green and total water footprints of spring maize production in Northeast China in 2019 and 2020 and compared the water footprint values at the provincial and municipal scales. In addition, this study analyzed the spatial variation and drivers of the water footprint. The results show that the average water footprints of spring maize production in Northeast China in 2019 and 2020 were 1.78 m3kg−1 and 2.00 m3kg−1, out of which the grey water footprint contributed the most, accounting for 55.19% and 49.85% of the total water footprint, respectively, while the blue water footprint contributed the least, accounting for only 17.44% and 18.68% of the total water footprint. At the provincial level, the water footprint of spring maize production in Northeast China was spatially clustered, with the lowest total water footprint in Heilongjiang Province and the highest total water footprint in Jilin Province. The spatial distribution difference of the spring maize unit yield was the fundamental factor explaining the difference in the water footprint. The precipitation, surface water resources, average temperature, effective irrigated area and the proportion of effective irrigated area also had impacts on the water footprint. This study provides a scientific basis for optimizing the distribution of spring maize production in Northeast China, formulating appropriate sustainable water resource management plans, improving water-use efficiency and realizing sustainable water resource management in Northeast China.
Unraveling complexity in changing mental health care towards person-centered care

Background Mental health care (MHC) needs to shift towards person-centered care to better meet people’s individual needs. Open Dialogue (OD) is well-aligned with this perspective and brings it into practice. This study focuses on exploring the change process within a pilot project involving three MHC teams as they transition to a person-centered OD practice. Our aim is to identify and reflect on the challenges faced by MHC professionals in adopting person-centered care, and shedding light on the underlying complexity of these challenges. By gaining a better understanding of these obstacles, we hope to contribute to the adoption of the person-centered approach in MHC practice. Methods Our research employed a qualitative design, involving a total of 14 semi-structured interviews with MHC professionals who were either trained in OD, OD trainees, or MHC professionals without OD training. To analyze the data, we utilized a hybrid approach that combined deductive – and inductive thematic analysis. Results We identified four distinctive challenges: (1) understanding and knowledge transfer, (2) (inter)personal process, (3) emotional discomfort, and (4) the need for multi-stakeholder participation and support. In practice, these challenges intersect and the appearance of and relationships between these challenges are not linear or disentangleable. Conclusion Upon careful consideration of these interdependent challenges, it became evident that embedding a person-centered approach like OD brings about systemic change, leading to an unfamiliar situation X. The research findings indicated that understanding and conveying the concept of person-centered care in practical settings poses significant challenges. The field of knowledge management helps to capture the complexity of understanding and transferring this knowledge. The change process necessitates an (inter)personal process and elicits emotional discomfort, as person-centered OD practice confronts a deeply entrenched paradigm in MHC. Achieving a shared understanding of person-centered care requires dedicated time and attention, while introducing this approach prompts broader discussions on underlying values and human rights in MHC. Current implementation efforts may underestimate or overlook these underlying values, but initiating an open dialogue can serve as an initial step in addressing the complexities.
Indications, Efficacy, Safety, and Clinical Outcomes of 585 nm Pulsed Dye Laser in Non-Malignant Laryngeal Lesions: A Systematic Review

The objective of this manuscript was to review the indications, efficacy, and safety of a 585 nm pulsed dye laser (PDL) in non-malignant laryngeal lesions. Following the PRISMA statement recommendations, three independent authors searched for articles published in PubMed/MEDLINE, the Cochrane Library, Google Scholar, Scielo, and Web of Science. A bias analysis was performed following NICE guidance tools. From the 506 identified publications, 19 observational studies met the inclusion criteria. The PDL improves vocal quality objectively and subjectively in vascular lesions (p < 0.005) and improves vocal quality in patients with dysplasia/leukoplasia without changing the natural history of the disease compared to other treatments. Reinke’s edema and granulomas require an average of 1.5 PDL sessions for resolution. Treatment of recurrent respiratory papillomatosis requires multiple sessions, with complete remission achieved in 50–70% of patients. Regardless of the lesion, the tolerance of the procedure under local anesthesia is exceptional (84–97%), and the results in terms of regression and vocal quality are promising. The complication rate is minimal, and the procedure does not interfere with other treatment alternatives. There is no consensus on laser settings. The lack of consistent use in evaluating vocal outcomes, whether objective or subjective, prevents the comparability between studies. The 585 nm pulsed dye laser appears to be an effective and safe therapeutic option in patients with non-malignant laryngeal pathology. Future controlled studies are needed to compare the 585 nm pulsed dye laser with other lasers or cold instrument procedures.