Miracle-dz/UniFAR-FTUs huggingface dataset:
The relationship between perceived stress and gastrointestinal symptoms in nursing and midwifery students

Aim: Students are subjected to different kinds of stressors, such as the pressure of academics with an obligation, an uncertain future and difficulties of integrating into the system. Although nursing and midwifery students experience a high level of stress during their training, there has been limited research on stress and its impact on the studentâ€™s physical responses, such as gastrointestinal symptoms. The aims of this study are to assess the prevalence of gastrointestinal symptoms in nursing and midwifery students and to examine the association between the perceived stress and gastrointestinal symptoms. Methods: This performed using cross-sectional descriptive study design study enrolled a total of 449 students participates in the study in a university degree program was carried out on 366 nursing and midwifery students accepted. A personal information questionnaire, Perceived Stress Scale and a Gastrointestinal Symptoms Questionnaire were administered through a self-reported system. Results: Seventy point two percent of the nursing and midwifery students experienced at least one gastrointestinal symptom, with 35.8% of students reporting at least three gastrointestinal symptoms. Most of the nursing and midwifery students complained of upper dysmotility and bowel symptoms. In addition, students who reported higher perceived stress were significantly more likely to complain of gastrointestinal symptoms. Compared to students with the lowest perceived stress level, the adjusted odds ratio for gastrointestinal symptoms in students with the highest perceived stress level was 6.45 times higher. Conclusions: Gastrointestinal symptoms that are highly prevalent among nursing and midwifery students are significantly associated with the perceived stress level. High perceived stress should be considered a risk factor for gastrointestinal symptoms. Based on the study findings, there is a critical need of instructing the nursing and midwifery students about how to manage their stress, a periodic meetings with the students to raise their awareness about the coping strategies w ith stress and stressors.
p16 downregulates VEGF and inhibits angiogenesis in breast cancer cells

Summary One of the major causes of failure in the treatment of breast cancer is the occurrence of metastasis. It is thus important to intervene at a key step such as angiogenesis for breast cancer treatment and prolongation of patient survival Vascular endothelial growth factor (VEGF) plays a pivotal role in tumor angiogenesis. Tumor suppressor gene p16 is a cyclin-dependent kinase inhibitor and a negative cell cycle regulator. It was observed that the degree of tumor malignancy correlates with angiogenic capacity and the loss of p16 activity. To examine whether p16 overexpression decreases VEGF gene expression and inhibits tumor angiogenesis in breast cancer cells, human breast cancer cell line MDA-MB-231 was transduced with recombinant adenovirus expressing p16. Our study showed that p16 downregulated VEGF expression and inhibited in vivo angiogenesis induced by MDA-MB-231 cells in nude mice.
I12 Problems Experienced By HD Clients during Daily Activities

Background People who have Huntington’s disease experience problems in performing daily activities. During occupational therapy we examine these activities in more depth, with the goal to help the client function as independent and safe as possible. Aims To gain a better insight into the experienced problems by HD clients during their daily activities and the prevalence of the activities restrictions. Methods/techniques Clients who live at home come to Topaz’ Huntington Centre Overduin to gain advice and information. During occupational therapy assessment we discuss the experienced problems on activity level. During 2013 we made an inventarisation of the problems that were assessed. These data are ordered according to Reed and Sanderson. Results/outcome In 2013 there were 33 clients who participated in the occupational therapy assessment of the advice centre. Thirty of those clients experienced problems during their daily activities. Three clients indicated that they didn’t experience any problems. In total, the clients indicated a total of 113 problems, of which 60 were different. More than half (56%) pertained to self-maintenance, of which 62,5% about personal care. Almost all (29/30) patients that reported problems also requested for help about selfmaintenance. The most prevalent problems are: Eating Drinking Dressing / Cooking / Writing / Everything takes more time Conclusion 30 out of 33 clients experienced problems with performing their daily activities. Most of those problems were caused due to insufficient personal care.
Bone Health and Young Females

&NA; This review provides an update on current theory and evidence regarding bone development and maturation in adolescent and young women. Societal and lifestyle trends affecting bone health in adolescent and young females is discussed. The factors underlying optimization of bone mass in adolescent and young females are then outlined and the prevalence and etiology of low bone mineral density (BMD) in young females is examined. Implications for physical therapist practice including diagnosis and treatment are presented.
Cystic Echinococcosis of the Liver: An Update for the Practicing Pathologist

Echinococcal infection of the liver continues to be a frequent problem in endemic regions, but it may also affect patients in nonendemic areas because of their migration. Therefore, infected patients presenting to treating clinicians and diagnostic pathologists in nonendemic areas often pose a treatment and diagnostic dilemma. In this review, we present a case of recurrent hepatic echinococcosis presenting in an urban academic medical center in the United States. In addition, the recent literature is reviewed with regard to diagnosis and treatment of hepatic echinococcal cysts, with particular focus on recently published expert consensus guidelines.
AUTONOMIC DISORDERS OF THE GASTROINTESTINAL TRACT

The unique and important role the nervous system plays in control of normal gut function continues to be defined because of continual advances in technology. Normal gut function occurs autonomously by communication between the enteric nervous system and interneurons of the gut. Dysfunction of this delicate system results in significant gastrointestinal disease. As future understanding of the brain-gut axis evolves, therapy for these gastrointestinal diseases will no doubt target the enteric nervous system.
Reverse total shoulder arthroplasty: a comprehensive review of biomechanics, surgical technique, and potential complications

The indications and use of reverse total shoulder arthroplasty (rTSA) have expanded because of the significantly predictable outcomes compared with other operative procedures for similar conditions. While relatively new in the United States with long-term outcome data not yet available, the use of rTSA in Europe over the past 2 decades has resulted in better overall function and pain relief in patients with difficult to treat disorders of the shoulder that result in chronic pain and dysfunction. Originally indicated for rotator cuff arthropathy, rTSA is proving to be a viable option for other disorders, including failed total shoulder arthroplasty, proximal humeral fracture (either complicated or sequelae from), tumor resection, and other bone-loss related pathologies. The following review article discusses the biomechanics, current implant design features, surgical technique, and possible complications related to rTSA.
Hypothalamic-pituitary dysfunction after radiation for brain tumors.

BACKGROUND Patients with brain tumors who are treated with radiation frequently have growth hormone deficiency, but other neuroendocrine abnormalities are presumed to be uncommon. METHODS We studied endocrine function in 32 patients (age, 6 to 65 years) 2 to 13 years after they had received cranial radiotherapy for brain tumors. The doses of radiation to the hypothalamic-pituitary region ranged from 3960 to 7020 rad (39.6 to 70.2 Gy). Nine patients also received 1800 to 3960 rad (18.0 to 39.6 Gy) to the craniospinal axis. Serum concentrations of thyroid, gonadal, and pituitary hormones were measured at base line and after stimulation. RESULTS Nine patients (28 percent) had symptoms of thyroid deficiency, and 20 patients (62 percent) had low serum total or free thyroxine or total triiodothyronine concentrations. Of the 23 patients treated only with cranial radiation, 15 (65 percent) had hypothalamic or pituitary hypothyroidism. Of the nine patients who also received spinal (and thus direct thyroid) radiation, three (33 percent) had evidence of primary thyroid injury. Seven of the 10 postpubertal, premenopausal women (70 percent) had oligomenorrhea, and 5 (50 percent) had low serum estradiol concentrations. Three of the 10 men (30 percent) had low serum testosterone concentrations. Overall, 14 of the 23 postpubertal patients (61 percent) had evidence of hypogonadism. Mild hyperprolactinemia was present in 50 percent of the patients. Responses to stimulation with corticotropin-releasing hormone and corticotropin were normal in all patients except one, who had panhypothalamic dysfunction. However, serum 11-deoxycortisol responses to the administration of metyrapone were low in 11 of the 31 patients (35 percent) tested. Three of the 32 patients, (9 percent) had no endocrine abnormalities, 9 (28 percent) had an abnormal result on tests of thyroid, gonadal, prolactin, or adrenal function, 8 (25 percent) had abnormalities in two axes, 8 (25 percent) in three axes, and 4 (12 percent) in all four axes. CONCLUSIONS Cranial radiotherapy in children and adults with brain tumors frequently causes abnormal hypothalamic-pituitary function. The most frequent changes are hypothyroidism and gonadal dysfunction, although subtle abnormalities in adrenal function may also be present.
13C-Urea Breath Test With Infrared Spectroscopy for Diagnosing Helicobacter pylori Infection in Children and Adolescents

Background and Objective Studies support the accuracy of 13C-urea breath test for diagnosing and confirming cure of Helicobacter pylori infection in children. Three methods are used to assess 13CO2 increment in expired air: mass spectrometry, infrared spectroscopy, and laser-assisted ratio analysis. In this study, the 13C-urea breath test performed with infrared spectroscopy in children and adolescents was evaluated. Methods Seventy-five patients (6 months to 18 years old) were included. The gold standard for diagnosis was a positive culture or positive histology and a positive rapid urease test. Tests were performed with 50 mg of 13C-urea diluted in 100 mL orange juice in subjects weighing up to 30 kg, or with 75 mg of 13C-urea diluted in 200 mL commercial orange juice for subjects weighing more than 30 kg. Breath samples were collected just before and at 30 minutes after tracer ingestion. The 13C-urea breath test was considered positive when delta over baseline (DOB) was greater than 4.0%. Results Tests were positive for H. pylori in 31 of 75 patients. Sensitivity was 96.8%, specificity was 93.2%, positive predictive value was 90.9%, negative predictive value was 97.6%, and accuracy was 94.7%. Conclusions 13C-urea breath test performed with infrared spectroscopy is a reliable, accurate, and noninvasive diagnostic tool for detecting H. pylori infection.
Renal sympathetic denervation in patients with treatment- resistant hypertension (The Symplicity HTN-2 Trial): a randomized controlled trial

1 Unidade de Hipertensão do Serviço de Cardiologia do Hospital de Clínicas de Porto Alegre da Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS. Correspondência para: Unidade de Hipertensão do Serviço de Cardiologia do HC-UFRGS. Rua Ramiro Barcelos, 2350 – 9035-309 – Porto Alegre, RS. Telefone: (51) 2101-8420. E-mail: mgus@terra.com. br Editor: Miguel Gus Renal sympathetic denervation in patients with treatmentresistant hypertension (The Symplicity HTN-2 Trial): a randomized controlled trial
ANALYSIS OF BUS TRANSIT ACCIDENTS: EMPIRICAL, METHODOLOGICAL AND POLICY ISSUES. FINAL REPORT

This report reflects the need to analyze bus transit accident data as a means of deriving more refined hypotheses concerning accident causality, and the view that research should include a discussion of empirical findings, methodological concerns and policy implications. Accident report data from PACE, the suburban bus agency within the Regional Transit Authority in the Chicago, Illinois metropolitan area, for 1982-84 were analyzed to derive refined safety measures. The analysis of over 1800 accidents led to the general conclusion that safety was well managed at the agencies. A full 89 percent of accidents involved collision with another vehicle or object, while 11 percent involved non-collision passenger injuries while boarding, alighting or moving about the bus. Severity of injury was low and occurred infrequently except for collisions in which autos rear-ended the bus. Accident occurrence appeared to increase near times of driver shift changes. Drivers with 3-6 years experience were overrepresented in accidents. This report concludes with policy recommendations and directions for future research.
Renal Tubular Acidosis with Osteomalacia

A 41-year-old female with renal tubular acidosis showed osteomalacia and pseudo-fracture of bilateral femoral necks. She had been treated with Shohl's fluid or NaHCO3, and acidosis was almost corrected, but hypophosphathemia and hypokalemia continued. So instead of these drugs, Uralyt-U was administered. As a result, acidosis was corrected and serum levels of P and K became normal. Uralyt-U was effective for this patient with renal tubular acidosis.
End of Life Care: The Experience of Seniors and Informal Caregivers

ABSTRACT As Canada's elderly population grows, an increasing number of seniors will require care as they face the end of life. Relatively little research attention, however, has been given to end-of-life issues, including those related to treatment and care for persons who are both old and dying. Families and health care providers have little direction and guidance to ensure an optimum quality of life for seniors prior to death and during the period of bereavement. This article presents an abbreviated summary of the literature regarding end-of-life issues and challenges for seniors who face a life threatening illness and are at, or near, the end of their lives. The article is also informed by a series of focus groups with elderly and other informal caregivers regarding the giving of help and getting support while caring for persons who are dying. It concludes with a response to this evidence by making a series of recommendations aimed at ensuring optimal end-of-life care for seniors who are dying and their families. RÉSUMÉ Au fur et à mesure de l'augmentation de la population des personnes âgées au Canada, un nombre croissant d'aîné(e)s auront besoin de soins pour affronter la fin de leur vie. Par ailleurs, les recherches ont peu porté sur les questions reliées à la fin de la vie, que ce soit celles des traitements ou des soins pour les personnes qui sont à la fois âgées et mourantes. Les familles et les fournisseurs de soins de santé disposent de peu d'orientation et d'encadrement pour assurer une qualité de vie optimale aux personnes âgées avant leur décès et pendant la période de deuil. Cet article présente un bref aperçu de la documentation sur les questions reliées à la fin de la vie et sur le défi que représente une maladie qui menace la vie des personnes âgées qui sont en fin de vie ou qui s'en rapproche. L'article se fonde sur des informations qui proviennent de groupes de réflexion sur les personnes âgées et d'autres aidants naturels et portent sur l'aide et l'appui que l'on donne et reçoit en s'occupant de personnes en fin de vie. L'article se termine par une série de recommandations qui portent sur les meilleurs soins pour les personnes âgées à l'article de la mort et pour leur famille.
Evaluation of the Efficacy of Intra-Operative Celiac Plexus Block on Post-Operative Analgesia, Stress Response, Gut Motility and Pulmonary Function in Upper Abdominal Surgery: A Double-Blind Randomized Study

Evaluation of the Efficacy of Intra-Operative Celiac Plexus Block on Post-Operative Analgesia, Stress Response, Gut Motility and Pulmonary Function in Upper Abdominal Surgery: A Double-Blind Randomized Study Celiac plexus block (CPB) is an effective method of providing intra-abdominal visceral analgesia. It also decreases the post-operative surgical stress response, enhance gut motility, and improve pulmonary function. We observed the effects of intra-operative CPB with wound infiltration on post-operative analgesia, surgical stress response, gut motility and pulmonary function following upper abdominal surgery (UAS) in a prospective double blind randomized study.
Comorbid psychiatric disorders with glaucoma

BackgroundGlaucoma is a heterogeneous group of conditions that involve cupping and atrophy of the optic nerve, with visual field loss and, often but not invariably, a high intraocular pressure. Literature on the psychiatric comorbidity in glaucoma patients is scanty. Aim of the studyThis study aimed to evaluate the prevalence of psychiatric disorders in glaucoma patients. Materials and methodsIn all, 384 individuals with glaucoma were examined using the General Health Questionnaire and 60 patients, those who gave score more than 15 on the General Health Questionnaire, were examined by the Arabic version of the Mini International Neuropsychiatric Interview. ResultsPsychiatric disorders were more common in female patients with age more than 60 years, who were living in urban areas, unmarried, workers, with education less than secondary school, had nonimpaired vision, nonpain, and using medical treatment only (no surgery), especially topical carbonic anhydrase inhibitor. Mini International Neuropsychiatric Interview identified that psychiatric disorders were found in 18.3% of the cases; 45.45% of them suffer from mood disorders and 54.54% from anxiety disorders. ConclusionPatients with glaucoma suffer from hidden psychiatric disorders that are often undetected. Among these disorders anxiety and depression are the most common. Careful detection and treatment could improve compliance in glaucoma patients.
Dose-Response Study of Human Growth Hormone in Venous Ulcers: Influence on Healing and Synthesis of Collagen Types I and III

Objective: To investigate the dose-response effect of topical human growth hormone on healing and local collagen synthesis and to study procollagen propeptides as markers of healing in chronic venous ulcers. Design: Double-blind, placebo-controlled study. Setting: Multicentre study, University Hospitals of Copenhagen, Denmark. Patients: Eighty-seven patients with chronic venous ulcers. Interventions: Solutions of growth hormone (Norditropin), 0.17 IU/ml, 1 IU/ml and 11.2 IU/ml, 0.1 ml/cm2/day, or placebo (groups 1–4) was administered daily except weekends for 6 weeks. Main outcome measures: Healing rates evaluated as weekly ulcer area reduction and complete healing. Local collagen synthesis was evaluated by measurement of the propeptides of collagen types I and III (PICP and PIIINP) in wound washings twice weekly during the first 3 weeks. Results: No significant difference in ulcer area reduction between the groups was seen, although patients treated with 0.17 IU/ml healed faster than the other groups (p = 0.14). Nine (45%), five (29%), seven (31%) and six (31%) ulcers in groups 1–4 respectively were healed at follow-up (p = 0.06–0.1, log rank test). PICP and PIINP increased by 21.4% per week, (14.5–28% per week) and 20.2% per week, (12.2–28.2% per week) respectively compared with placebo, p < 0.05. Both PIIINP and PICP at 3 weeks correlated significantly with the healing rates, r = 0.44, p < 0.001 and r = 0.34, p < 0.005. Conclusion: The study failed to demonstrate a significant influence on healing, whereas collagen synthesis was stimulated dose-dependently by growth hormone. Procollagen propeptides are sensitive markers of growth hormone action and may be useful markers of healing in clinical investigations in chronic venous ulcers. Lower doses of growth hormone should be considered in future studies.
Section 504-Only Students

Students with disabilities fit into two groups: (a) those with individualized education plans (IEPs), who are eligible under both the Individuals With Disabilities Education Act and Section 504, and (b) those with 504 plans, who are eligible under Section 504 only. Updating the only previous data about the incidence of 504-only students, which was a non-governmental survey prior to the 2008 ADA amendments to the Americans With Disabilities Act, this study analyzed the data from the federal government’s 2009–2010 Civil Rights Data Collection (CRDC). The first finding was that the average proportion of 504-only students in the nation’s public schools is approximately 1%. Second, the percentage of this group is significantly higher for (a) Black and Hispanic than for White students and (b) for males than for females. Third, the percentage of 504-only students is significantly higher for (a) high IEP than for low IEP schools, (b) non-charter than for charter schools, and (c) non-Title I than Title I schools. These results suggest the need for more diligent and consistent identification of 504-only students and for more current and comprehensive research.
Histopathological studies of renal and hepatic tissues of hyperglycemic rats administered with traditional herbal formulations

Background and Aim: The present study investigated the capacity of single and combinatorial herbal formulations of leaf extracts of Acanthus montanus, Asystasia gangetica, Emilia coccinea, and Hibiscus rosasinensis to reverse renal and hepatic injuries in alloxan‐induced hyperglycemic rats. Settings and Design: A total of 102 male Wistar rats were allotted into 17 groups of six rats each. The animals were deprived of food and water for additional 16 h before the commencement of treatment. The animal groups were designated on the basis of treatments received at regular intervals of 2 days for 30 days. Materials and Methods: Histological images of renal and hepatic tissue sections were captured using charge‐couple device camera under a light microscope. Blood biochemical indices were measured using spectrophotometric methods. Statistical Analysis: The data were analyzed by one‐way ANOVA followed by Dunnett test, with the level of significance set at P < 0.05. Results: Histopathological studies of the untreated hyperglycemic rats showed evidence of hypertrophy and disarrangements of the hepatic parenchyma. The architecture of hepatic parenchyma showed evidence of varying levels of necrosis and restoration of cellular integrity following herbal treatment. Similarly, histopathological studies of the renal tissues showed evidence of cells swellings and fibrotic changes of the glomeruli. However, herbal treatments restored cellular integrity and reversed glomeruli atrophy and turf disarrangement. In addition, blood biochemical indices showed evidence of restoration of cellular integrity. Conclusion: Both histological and biochemical indices revealed varying capacities of single and combinatorial herbal formulations to reverse renal and hepatic tissues injuries in hyperglycemic rats. Key words: Hepatic, herbal formulations, histology, hyperglycemia, renal