Miracle-dz/UniFAR-FTUs huggingface dataset:
Therapeutic potential of parkin as a tumor suppressor via transcriptional control of cyclins in glioblastoma cell and animal models

Parkin (PK) is an E3-ligase harboring tumor suppressor properties that has been associated to various cancer types including glioblastoma (GBM). However, PK is also a transcription factor (TF), the contribution of which to GBM etiology remains to be established. Methods: The impact of PK on GBM cells proliferation was analyzed by real-time impedance measurement and flow cytometry. Cyclins A and B proteins, promoter activities and mRNA levels were measured by western blot, luciferase assay and quantitative real-time PCR. Protein-protein and protein-promoter interactions were performed by co-immunoprecipitation and by ChIP approaches. The contribution of endogenous PK to tumor progression in vivo was performed by allografts of GL261 GBM cells in wild-type and PK knockout mice. Results: We show that overexpressed and endogenous PK control GBM cells proliferation by modulating the S and G2/M phases of the cell cycle via the trans-repression of cyclin A and cyclin B genes. We establish that cyclin B is regulated by both E3-ligase and TF PK functions while cyclin A is exclusively regulated by PK TF function. PK invalidation leads to enhanced tumor progression in immunocompetent mice suggesting an impact of PK-dependent tumor environment to tumor development. We show that PK is secreted by neuronal cells and recaptured by tumor cells. Recaptured PK lowered cyclins levels and decreased GBM cells proliferation. Further, PK expression is decreased in human GBM biopsies and its expression is inversely correlated to both cyclins A and B expressions. Conclusion: Our work demonstrates that PK tumor suppressor function contributes to the control of tumor by its cellular environment. It also shows a key role of PK TF function in GBM development via the control of cyclins in vitro and in vivo. It suggests that therapeutic strategies aimed at controlling PK shuttling to the nucleus may prove useful to treat GBM.
CFD Modeling and Comparison With Data From the NIST Reference Spray Combustor

Validation of computational fluid dynamics (CFD) predictions for spray combustion application has been a challenging task due to difficulties in both modeling and experimental measurements. However, validation is considered to be an essential exercise for the success of CFD tools in the development of future combustion systems. This paper describes a benchmark spray combustion database collected at National Institute of Standards and Technology (NIST) and validation of a commercial CFD code using these data. Swirl-stabilized combustion of methanol at lean operating conditions in the NIST reference spray combustor facility was selected to be the baseline case for which both measurements and predictions were made. A comparison is presented of CFD predictions with experimental data for droplet size and velocity, and spray volume flux. The agreement between the CFD calculations and the experimental data is generally good once certain adjustments were made to the measured data close to the injector tip. The adjustments were made based on extrapolation from more accurate downstream measurements. Specification of droplet initial conditions for computational modeling that accurately reflect the laboratory conditions remains a significant issue that needs further improvement.
Computer programmers as volunteer workers: The case of the free and open source software movement

The primary benefit of free and open source computer software to the community and not-for-profit sectors lies in the fact that it is almost always completely free of both charge and administrative encumbrance. A more detailed analysis of the context in which the software is created exposes an even greater relevance to the human resource and third sector management however - the individuals who create this software are volunteers. This paper introduces free and open source software, highlights the key technical and social factors that make it so interesting to the human resource management context, and applies the Levy (2006) framework to correlate the production of open source computer software with the Volunteering Australia definition of volunteering.
New Perspectives on Old and New Therapies of Staphylococcal Skin Infections: The Role of Biofilm Targeting in Wound Healing

Among the most common complications of both chronic wound and surgical sites are staphylococcal skin infections, which slow down the wound healing process due to various virulence factors, including the ability to produce biofilms. Furthermore, staphylococcal skin infections are often caused by methicillin-resistant Staphylococcus aureus (MRSA) and become a therapeutic challenge. The aim of this narrative review is to collect the latest evidence on old and new anti-staphylococcal therapies, assessing their anti-biofilm properties and their effect on skin wound healing. We considered antibiotics, quorum sensing inhibitors, antimicrobial peptides, topical dressings, and antimicrobial photo-dynamic therapy. According to our review of the literature, targeting of biofilm is an important therapeutic choice in acute and chronic infected skin wounds both to overcome antibiotic resistance and to achieve better wound healing.
Strategi Double Skin Fasade pada Bangunan Kampus National Central University dalam Menurunkan Kebutuhan Energi Pendinginan

Building facade plays significant role in building energy efficiency and sustainability. Double Skin Facade (DSF) strategy comes as one of solution in advance building facade design technology. The aim of this study is to observe the performance of DSF configuration (air gap width) and materials in terms of reducing cooling energy for energy efficiency in case study buildings in hot humid climate in Taiwan. DesignBuilder- EnergyPlus was used as simulation tool in this study. Two scenario based on the placement of DSF strategy were conducted. The results show that combination of 1.2m air gap and double glazed Low E could reduce the cooling energy demand up to 31.28%. This study proved that DSF strategy is possible to be applied on hot humid climate such as Taiwan.
Sowing Date Affects Maize Development and Yield in Irrigated Mediterranean Environments

Timely sowing is critical for maximizing yield for both grain and biomass in maize. The effects of early (mid-March), normal (mid-April), and late (mid-May) sowing date (SD) were studied over a three-year period in irrigated maize under Mediterranean conditions. Early SD increased the number of days from sowing to plant emergence. Late SD reduced the number of days to plant maturity, and had higher forage yields, higher grain humidity, and taller plants. The average grain and forage yields achieved were 13.2 and 21.3 Mg ha−1; 14.0 and 25.1 Mg ha−1; and 12.8 and 27.6 Mg ha−1, for crops with early, normal, and late SD, respectively. The data support the general perception of farmers that April sowings are the most appropriate in the area where the experiments were carried out. Early SD resulted in lower population densities, while later SD did not yield (grain) as high. However, late SD produced taller plants that contributed to achieve higher forage yields. Late SD could be interesting for double annual forage cropping systems. Sowing at the most appropriate time, when the soil is warm, ensures a good level of maize grain production. Future research could focus in the effect of SD for total annual yields in double-annual cropping systems
Expect the Unexpected

This study originates from the recognition that project management research is replete with normative theories on what need projects to be successful. However, it has performed worse with respect to assisting the understanding of how and why similar projects do not have similar performances during their life-cycles. It claims that the poor performance of major infrastructure projects, acknowledged by cost overruns and scheduling delays, is due to their lack of resilience when confronted with critical events that are inherent in their life-cycle. Therefore, it addresses the overarching question: How do projects cope with the critical events that occur at some point in their life-cycle? And why and how are some troubled projects able to maintain positive adjustments (cope successfully) while others cannot? By addressing these questions, the first goal of this study is to reveal the "resilience enablers". These are factors and conditions enabling the successful coping process (maintaining performance after the critical event) in projects confronted with unexpected events. The second goal is to translate the new knowledge of "resilience enablers" into recommendations for practitioners to enable them to actually make use of the insight into a troubled project's behavior. To study these questions, a qualitative research design was developed. It is articulated on the exploratory case study of one of the most important infrastructure project of this century. The result consists of two sets of findings, both relate to the critical events' managements and the factors and conditions that enabled the project's resilience. This thesis contributes to project management research with a middle range theory. The project performance can be seen and explained from a new and original perspective of project resilience. It also contributes to the project's management practice with recommendations aiming to help project actors to 1) identify and assess the resilience of their project organization, along with the identification and management of the risks. And to 2) maintain project system performance after the critical event through continuous adoption of risk-focused, and protection-focused strategies, which imply uncostly measures that enable project resilience.
Heat transfer in oscillating flows with sudden change in cross section

Oscillating fluid flow (zero mean) with heat transfer, between two parallel plates with a sudden change in cross section, was examined computationally. The flow was assumed to be laminar and incompressible with inflow velocity uniform over the channel cross section but varying sinusoidally with time. Over 30 different cases were examined; these cases cover wide ranges of Re{sub max} (187.5 to 30,000), Va (1 to 350), expansion ratio (1:2, 1:4, 1:8, and 1:12) and A{sub r} (0.68 to 4). Three different geometric cases were considered (asymmetric expansion/contraction, symmetric expansion/contraction, and symmetric blunt body). The heat transfer cases were based on constant wall temperature at higher (heating) or lower (cooling) value than inflow fluid temperature. As a result of the oscillating flow, the fluid undergoes sudden expansion in one-half of the cycle and sudden contraction in the other half. In this paper, one heating case is examined in detail, and conclusions are drawn from all the cases (documented in detail elsewhere). Instantaneous friction factors and heat transfer coefficients, for some ranges, of Re{sub max} and Va, deviated substantially from those predicted with steady-state correlations.
New Developments of Friction Models in Brake Systems

The dynamics of friction in brake systems is correlated with the wear-process in the contact area of brake pad and brake disc. The time-dependence of characteristic patterns of wear on the brake pad were used to introduce a new theory of friction in brake systems. With a set of differential equations, describing the friction coefficient, explanations for a time-variant friction behavior and fading effects have been found. To get an explicit insight into the dynamic changing of the surface topography in the boundary layer in detail we furthermore developed a tool, which bases on the discretization with a Cellular Automaton. In this paper we will show new results in the fundamental dynamics of brake systems.
Advances in Single-Cell Sequencing Technology and Its Applications in Triple-Negative Breast Cancer

Abstract Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer and is mainly treated with chemotherapy-based combination therapy. In recent years, with the increasing development of global precision medicine, single-cell sequencing (SCS) has become one of the most promising technologies in the field of biotechnology. Moreover, the related application of this technology in TNBC has been applied and developed. By using SCS to study the heterogeneity of TNBC tumor cells, metastasis, drug resistance mechanisms, mutations, and cloning; it can further guide clinical chemotherapy, targeted therapy, and immunotherapy. To further reflect the importance of SCS in TNBC, this paper elaborated on and summarized the research and application progress of SCS in TNBC.
The Patient Centered Assessment Method (PCAM) for Action-Based Biopsychosocial Evaluation of Patient Needs: Validation and Perceived Value of the Dutch Translation

The Patient Centered Assessment Method (PCAM) is an action-based tool that supports professionals to engage in a biopsychosocial assessment with patients and measure their needs. It is a promising tool for person-centered care. As the Netherlands lacks such a tool, a Dutch version was developed. Furthermore, we aimed to contribute to the relatively limited insights into the psychometric properties and value of the tool when used as part of a needs assessment in primary care. Confirmatory factor analysis was used to study construct validity and Cronbach’s alpha was computed to assess reliability. Furthermore, we interviewed 15 primary care professionals who used the PCAM. It was confirmed that each PCAM domain measures a separate construct, informed by the biopsychosocial model. The tool showed adequate reliability (Cronbach’s alpha = 0.83). Despite face validity concerns, the tool was mainly valued for measurement of patient needs and to facilitate action planning. Criticism of the PCAM pertained to a limited focus on the patient perspective, which is one of the crucial aspects of person-centered care. These rich, mixed-method insights can help to improve the value of the PCAM, as one of the few multifunctional tools to support professionals in holistic assessments.
Evaluation of the effectiveness of physiotherapy in patients after oncological breast cancer treatment based on spirometric indicators

Introduction The aim of this study is to evaluate the effects of physiotherapy in patients who underwent oncological treatment including spirometric indicators: FEV1, VC, FVC, PEF, FEV1/FVC, FEF25, FEF50, FEF75. Moreover, the possible influence of duration of physiotherapy on ventilation activity of lungs was assessed. Material and methods The study considered 91 women after breast cancer therapy qualified for outpatient physiotherapy. All patients underwent radiation therapy, and more than half of the women received concurrent chemotherapy. To assess rates of respiratory disorders, the patients were subjected to spirometric tests. The clinical status of examined subjects was also taken into account. Results Statistical analysis showed that the duration of physiotherapy contributed to increased ventilation index FEV1% – with each treatment day corresponding to an average of 1.8 units. In contrast, the involvement of lymph nodes radically reduced the level of PEF by as much as 64 units. The results of linear modelling provided evidence of statistically significant effects of chemotherapy on spirometric indicators. What is more, a statistically significant impact of time of rehabilitation on FEV1 increase was estimated. Conclusions Physiotherapy leads to improvement of lung functions in patients with breast cancer after oncological treatment; progress is more evident in patients with advanced cancer after radical treatment.
Different Wines from Different Yeasts? “Saccharomyces cerevisiae Intraspecies Differentiation by Metabolomic Signature and Sensory Patterns in Wine”

Alcoholic fermentation is known to be a key stage in the winemaking process that directly impacts the composition and quality of the final product. Twelve wines were obtained from fermentations of Chardonnay must made with twelve different commercial wine yeast strains of Saccharomyces cerevisiae. In our study, FT-ICR-MS, GC-MS, and sensory analysis were combined with multivariate analysis. Ultra-high-resolution mass spectrometry (uHRMS) was able to highlight hundreds of metabolites specific to each strain from the same species, although they are characterized by the same technological performances. Furthermore, the significant involvement of nitrogen metabolism in this differentiation was considered. The modulation of primary metabolism was also noted at the volatilome and sensory levels. Sensory analysis allowed us to classify wines into three groups based on descriptors associated with white wine. Thirty-five of the volatile compounds analyzed, including esters, medium-chain fatty acids, superior alcohols, and terpenes discriminate and give details about differences between wines. Therefore, phenotypic differences within the same species revealed metabolic differences that resulted in the diversity of the volatile fraction that participates in the palette of the sensory pattern. This original combination of metabolomics with the volatilome and sensory approaches provides an integrative vision of the characteristics of a given strain. Metabolomics shine the new light on intraspecific discrimination in the Saccharomyces cerevisiae species.
Optimal Load Shedding

This chapter first introduces the traditional load-shedding methods such as under-frequency or under-voltage load shedding, and then studies optimal power system load-shedding methods. These include intelligent load shedding (ILS), distributed ILS (DILS), Everett optimization, analytic hierarchical process (AHP), and network flow programming (NFP). Load shedding by frequency relays is the most commonly used method for controlling the frequency of power networks within set limits and maintaining network stability under critical conditions. Blackouts are becoming more frequent in industrial countries because of network deficiencies and continuous load growing. Transmission congestion occurs when there is insufficient transmission capacity to meet the demands of all customers. The chapter discusses several approaches for optimal load shedding, which can be used for congestion management. It presents simple-load shedding or load-management methods for congestion management.
PENGARUH RASIO LIKUIDITAS TERHADAP PROFITABILITAS (Studi Kasus Pada Bank Syari'ah Mandiri Tahun 2004-2007)

ABSTRAK Bank Syari'ah merupakan lembaga keuangan intermediary yang memiliki fungsi menghimpun dana dari masyarakat, dan menyalurkannya kembali pada masyarakat. Dalam kegiatan operasionalnya, bank Syari'ah dihadapkan pada dua persoalan, yaitu di satu sisi bank harus menjaga penarikan dana dari sumber dana yang dititipkan seperti giro, tabungan dan simpanan lainnya. Sementara di sisi lain bank harus menjaga penarikan permintaan dana seperti kredit yang diberikan. Maka sebuah perbankan harus cakap dalam mengelola kas, karena jika jumlah kas yang tersedia terlalu besar akan mengakibatkan kas yang menganggur (idle cash), sedangkan kas yang terlalu kecil dapat berakibat situasi illikuid. Profitabilitas merupakan salah satu pengukur kinerja keuangan sebuah perbankan. Jika sebuah bank mempunyai profitabilitas bagus maka kelangsungan hidup bank tersebut akan terjamin. Namun sebaliknya jika bank mempunyai profitabilitas buruk maka kelangsungan hidup bank tidak akan bertahan lama. karena bank tersebut tidak mampu untuk memenuhi biaya-biaya operasional. Selain itu minimnya tingkat profitabilitas, juga akan berdampak sulitnya bank untuk mengembangkan usahanya. Namun untuk mendapatkan keuntungan, bank harus mengorbankan likuiditas, sebaliknya jika bank menginginkan likuiditas, maka kesempatan umtuk mendapat keuntungan akan hilang. Adanya trade-off antara likuiditas dengan profitabilitas, didasarkan pada argumen bahwa investasi pada pendanaan jangka pendek memberi efek yang berlawanan terhadap likuiditas dan profitabilitas. Investasi pada aset lancar (liquid assets) walaupun akan meningkatkan likuiditas, namun tidak dapat menghasilkan keuntungan (profit) sebanyak investasi pada aset tetap. Pendanaan yang berasal dari kewajiban lancar walaupun lebih murah dan lebih menjanjikan dari segi laba, namun lebih berisiko. Obyek dalam penelitian ini ialah Bank SyariA¢â‚¬â„¢ah Mandiri (BSM) tahun 2004-2007, dengan jumlah sampel 48. Adapun variabel independen yang diguanakan terdiri (1) ratio of liquid assets to total assets (LTA), (2) ratio of liquid assets to deposits (LAD) dan (3) ratio of financing to deposits (FDR). Sedangkan variabel dependennya ialah return on assets (ROA). Metode yang digunakan dalam peneltian ini, menggunakan regresi berganda. Hasil penelitian ini menunjukkan variabel LTA berpengaruh positif dan signifikan, dengan nilai sebesar 2.971 2.021 dan signifikansi 0.005, Variabel LAD berpengaruh negatif dan signifikan yang ditunjukkan nilai thitung-2.371 lebih kecil t tabel -2,021 dan signifikansi 0.022. Dan variabel FDR tidak berpengaruh dan signifikan dengan nilai thitung lebih kecil ttabel (656 2.021) dengan tingkat signifikansi 0.515. Namun secara simultan variabel independen berpengaruh terhadap variabel dependen dengan nilai Fhitung sebesar 2.946 lebih besar F tabel 2.84 dan tingkat signifikansi 0.043.
Morphology of Coronary Artery Disease in a Patient with, Psoriasis Presenting with an Acute Coronary Syndrome

Background: This study was designed to evaluate the patterns of coronary artery disease in patients with Psoriasis presenting with acute coronary syndrome (ACS). Methods: This was a prospective, observational study, conducted on 28 patients with Psoriasis, presenting with acute coronary syndrome undergoing coronary angiogram from September 2017 to March 2021. All patients had undergone coronary angiogram; severity and morphology of coronary lesion were analyzed. Echocardiography was used to analyze LV wall motion and LV function. Results: The study showed that of 28 patients with Psoriasis who presented with ACS, 45.8% of patients were presented with NSTEMI, 39.2% % STEMI, and Unstable angina 15%. The average time of presentation after the onset of the symptom was 14.8 hours. 66 % of patients were a smoker. Coronary involvement 50% had TVD, 40% DVD, and 10% had SVD. In 77.6% culprit vessel was LAD, 10.4% LCX, and 12% RCA. In 75% of patient's coronary lesion was located in the proximal LAD. Chronic total occlusion was found in almost 26% of patients. Extensive LV wall motion abnormality with severe LV systolic dysfunction was noted in Psoriasis patients at the time of presentation (mean LVEF=28%). Conclusions: Psoriasis patients presenting with ACS, associated with increased severity of coronary lesions, multivessel involvement, and depressed LV systolic function.