Miracle-dz/UniFAR-FTUs huggingface dataset:
Clinical Evaluation of the Safety, Efficacy and Tolerability of Lanthanum Carbonate in the Management of Hyperphosphatemia in Patients with End-Stage Renal Disease

: Patients with progressive chronic kidney disease (CKD) commonly develop mineral and bone abnormalities and extraskeletal calcifications with following increased cardiovascular risk. A key pathophysiological role is played by hyperphosphatemia. Since diet and dialysis are often insufficient to control serum phosphorus levels, many patients require treatment with phosphate binders. Among them is lanthanum carbonate, an aluminum-free non-calcium-based compound. The present review summarizes the most recent literature data concerning the safety, efficacy and tolerability of lanthanum carbonate in patients with end-stage renal disease and hyperphosphatemia. The drug is taken orally as chewable tablets or powder with only minimal gastrointestinal absorption and resulting reduced risk of tissue deposition and systemic drug interactions. The dissociation of the drug in the acid environment of the upper gastrointestinal tract induces the release of lanthanum ions, which bind to dietary phosphate forming insoluble complexes then excreted in the feces. Even though there is no clear evidence that lowering serum phosphorus levels can improve patient-centered outcomes, a mortality benefit with all phosphate binders, especially non-calcium containing ones, is not excluded. Lanthanum carbonate has been suggested to decrease all-cause mortality but not cardiovascular event rate compared to other phosphate binders. It induces a lower suppression of bone turnover than calcium carbonate and calcium acetate and may improve systolic function and cardiac dimension compared to calcium carbonate. Moreover, the use of lanthanum carbonate has been associated with better nutritional status compared to other phosphate binders, lower risk for hypercalcemia than calcium-containing binders, and amelioration of mild metabolic acidosis contrary to sevelamer hydrochloride. Main adverse effects include nausea, alkaline gastric reflux, gastric deposition fecal impaction, reduction of gastrointestinal absorption of some drugs including statins, angiotensin-converting enzyme inhibitors and some antibiotics such as fluoroquinolones or tetracyclines.
The value-relevance of social media activity of Finnish listed companies

Purpose – The use of social media tools by companies is common, but the links between the use of multiple social media tools by companies and stock price changes are largely unknown. Therefore, this study aims to analyze the value-relevance of social media activities on Facebook (FB), Instagram (IG), LinkedIn (LI), Twitter (TW) and YouTube (YT). Design/methodology/approach – Stock market data and hand-picked social media data in this study were collected from Finland, a small language area with consistent International Financial Reporting Standards (IFRS) reporting practices, in the expectation of better comparability and lower noise in the data. This study uses correlation, regression and factor analyses for a sample of 105 Finnish public limited companies listed on the Nasdaq Helsinki stock exchange. Findings – This paper finds evidence that social media activity is an important area of analysis and that the activity and popularity of a company in social media are value-relevant variables in forecasting stock prices. Practical implications – Not all social media activities are necessarily equally important for managers and investors. Focus on visual messages in social media is recommended. Originality/value – The findings of this study highlight the value-relevance of usingmultiple visual social media channels, particularly IG and YT. This paper suggests avenues for future research and for analyzing social media information.
Daniel et al_2015_revised

Plant genomes contain a large number of genes encoding for berberine bridge enzyme (BBE)-like enzymes. Despite the widespread occurrence and abundance of this protein family in the plant kingdom, the biochemical function remains largely unexplored. In this study we have expressed two members of the BBE-like enzyme family from Arabidopsis thaliana in the host organism Komagataella pastoris. The two proteins, termed AtBBE-like 13 and AtBBE-like 15, were purified and their catalytic properties were determined. In addition, AtBBE-like 15 was crystallized and structurally characterized by X-ray crystallography. Here, we show that the enzymes catalyze the oxidation of aromatic allylic alcohols, such as coumaryl-, sinapyl-, and coniferyl alcohol, to the corresponding aldehydes and that AtBBE-like 15 adopts the same fold as vanillyl alcohol oxidase as previously reported for berberine bridge enzyme and other FAD-dependent oxidoreductases. Further analysis of the substrate range identified coniferin, the glycosylated storage form of coniferyl alcohol, as a substrate of the enzymes whereas other glycosylated monolignols were rather poor substrates. A detailed analysis of the motifs present in the active sites of the BBE-like enzymes in A. thaliana, suggested that 13 out of 28 members of the family might catalyze similar reactions. Based on these findings, we propose a novel role of BBE-like enzymes in monolignol metabolism that was previously not recognized for this enzyme family. http://www.jbc. org/cgi/doi/10.1074/jbc.M115.659631 The latest version is at JBC Papers in Press. Published on June 2, 2015 as Manuscript M115.659631 Copyright 2015 by The American Society for Biochemistry and Molecular Biology, Inc. by gest on July 0, 2020 hp://w w w . jb.org/ D ow nladed from
Nurses' challenges: Critically Ill Children Outcomes at Pediatric Intensive Care Units during COVID-19 crisis

Background: Work crisis facing critical care nurses in pediatric intensive care unit are international issues. Therefore, understanding the challenges that faces the nurses and overcome these challenges is crucial in retaining them. The Study aims: to identify the challenges faced Pediatric Intensive Care Units (PICUs) nurses & to assess critically ill children outcomes at PICUs during COVID-19 crisis. Study design: the descriptive design was used. Setting: This study carried out at all PICUs in Port Said hospitals. Study subject: Convenient sampling of (115) PICUs nurses & (75) critically ill children in PICUs have participated in this study from the beginning of November 2020 to the beginning of February 2021.Data collection tools: a semi-structured electronic form applied to PICUs nurses. Three tools were used in the study, tool I: Assessment interview questionnaire sheet composed of two parts, socio-demographic data PICUs nurses & critically ill children in PICUs. Tool II: Challenges faced PICUs nurses during COVID 19 crisis Tool III: critically ill children out comes. Results: The high percentages (97.1%) of studied PICUs nurses faced moral challenges followed by social, psychological challenges, challenges related to the nature of the disease, challenges related to staff and resources deficiency then physical challenges (93.9%, 92.2%, 91.3%, 90.4%, 88.7%) respectively. The results also indicated that two third (60.0%) of studied critically ill children out comes during COVID 19, their hospital' Length of stay was less than one month. While less than one quarter (18.7%) of them, their hospital' Length of stay was more than two months and less than one half (42.7%) of them were died, 40.0% were Discharged& 17.3% of them were Survived cases &still on mechanical ventilation. Conclusion: The high percentages of PICUs nurses faced moral challenges followed by social, psychological challenges, challenges related to nature of the disease, challenges related to staff and resources deficiency then physical challenges. Subsequently, two third of studied critically ill children, their hospital' Length of stay was less than one month & and less than one half of them were died, 40.0% were Discharged & the other Survived and still on mechanical ventilation. Recommendations: Researches should be conducted to enhance knowledge on COVID19 prevention and management & thus manipulation the challenges faced PICUs.
Operational Disturbances in Supply Management

Nowadays global companies view the world as a single entity, sourcing materials from anywhere and performing operations to create the optimal supply chain for their products. This leads to an increasing complexity which is driving supply management to become a core capability of businesses. As supply chains are inherently vulnerable to disturbances, supply management will have to play a key role in the field of risk analysis and risk management. An increased awareness of sources of disturbances is essential to create significant improvements in the handling and prevention of disturbances. The purpose of this thesis is to identify and classify sources of disturbance which can have a negative influence on a company’s supply management. This is achieved by the investigation of theories available in literature, as well as identifying and analyzing the disturbances in the supply management of an international manufacturing company. Additionally, the theories on disturbance management are reviewed to create a foundation for managerial implications. The company studied is Husqvarna, which currently is in a situation with several disturbances in its supply management. The performed case study aims at both, describing these phenomena, as well as testing of the theories. The chosen qualitative approach makes it possible to gain in-depth knowledge and investigate different aspects of sources of disturbances in this case study. The interviews performed are standardized open ended questionnaires in order to get in-depth knowledge of the situation. The empirical findings are then analyzed in regard to the purpose of the thesis. The goal of this analysis is to compare the sources of disturbances of the classification scheme created in the literature review to the respondents’ answers from the interviews. Moreover, inputs and opinions from the respondents on how to manage disturbances are connected with the theories provided in the literature review within this field. Various sources of disturbance with a negative influence on the supply management of companies are identified. It was also possible to compare the classification scheme which was created based on the theoretical findings with the finding of the case study of Husqvarna. Consequently a holistic overview of potential and actual sources of disturbance in supply management has been created. Furthermore, it is possible to contribute to the body of knowledge on how to manage disturbances in supply management. The provided insights highlight implications that can help companies to successfully manage disturbances and hence improve their performance.
Deep Learning-based Transmitter identification on the physical layer

—An essential part of most wireless communications systems is the identiﬁcation of a transmitter by a receiver. Being able to identify a transmitter at the physical layer gives context to the communication itself, but is also an important building block for more advanced techniques such as physical layer security. It can also be used to reduce overhead in the transmission of small packets. Previous works have shown the usefulness of applying deep learning to this task, however, as seen in those works, channels characteristics tend to capture the ﬁngerprinting abilities of deep learning systems, rendering them very sensitive to changes in the radio propagation environment. This work focuses on reducing the impact of channel effects on identiﬁcation performance and generalisation to changing conditions, something that has been little addressed in the literature, and show that increasing channel variations in the data used to train a neural network can increase its resiliency to channel modiﬁcations, leading to a gain of up to 21.3 percentage points in accuracy compared to the naive approach found in the literature. The datasets collected for this paper are available online, as well as the tools to collect new ones, in the hope that they can be reused by the community.
Chlamydia trachomatis infection among 15-35 year-olds in Baltimore, MD, USA

Elizabeth Eggleston, DrPH1, Susan M Rogers, PhD1, Charles F Turner, PhD2, William C. Miller, MD, PhD4, Anthony M Roman, MA3, Marcia M. Hobbs, PhD4, Emily Erbelding, MD5, Sylvia Tan, MS1, Maria A. Villarroel, MA1,7, and Laxminarayana Ganapathi, PhD6 1Statistics and Epidemiology Division, Research Triangle Institute, Washington DC 20015, USA 2City University of New York, Queens College and the Graduate Center, Flushing, NY 11367, USA
SARS-CoV-2 Isolation from Cuban COVID-19 Patients

Enrique Noa Romero1*, Juliet Maria Enriquez Puertas1, Liuber Yans Machado Zaldivar2, Nibaldo L Gonzalez Sosa1, Teresita de Jesus Montero Gonzalez3, Viviana Falcon Cama4, Anamarys Suarez Batista1, Madelin Blanco de Armas2, Marielis Cabrera Garrido1, Yenicet Infante Hernandez1, Lien Laguna Oliva3, Nelson Acosta Rivero4, Laura Sofi a Rizo Lopez2, Maria Teresa Perez Guevara2, Marta Dubed Echevarria1, Mireida Rodriguez Acosta2 and Otto Cruz Sui1 1Department of Virology, Civilian Defense Scientifi c Research Center, Cuba 2Department of Molecular Biology, Civilian Defense Scientifi c Research Center, Cuba 3General Military Hospital “Dr. Luis Diaz Soto”, Cuba 4Center of Genetic Engineering and Biotechnology, Cuba *Address for Correspondence: Enrique Noa Romero, Department of Virology, Civilian Defense Scientifi c Research Center, Autopista Nacional Carretera de Jamaica, San Jose de las Lajas, Mayabeque, CP 32700, Cuba, E-mail: enrnoa@infomed.sld. cu/diaglisida@infomed.sld. cu
on Dietary Reference Values for vitamin C

Following a request from the European Commission, the Panel on Dietetic Products, Nutrition and Allergies (NDA) derived Dietary Reference Values (DRVs) for vitamin C. The Panel concludes that an Average Requirement (AR) can be derived from indicators of vitamin C status, as well as a Population Reference Intake (PRI) assuming a coefficient of variation (CV) of 10 %. Several health outcomes possibly associated with vitamin C intake were also considered but data were found to be insufficient to establish DRVs. For healthy adults, the AR is determined from the quantity of vitamin C that balances metabolic vitamin C losses and allows the maintenance of an adequate body pool characterised by fasting plasma ascorbate concentrations at around 50 μmol/L. In men, an AR of 90 mg/day of vitamin C and a PRI of 110 mg/day are proposed. As no value for metabolic losses is available in women, the AR for women is extrapolated from the AR for men on the basis of differences in reference body weight, and an AR of 80 mg/day and a PRI of 95 mg/day are proposed. For infants aged 7-11 months, the Panel has decided to retain the PRI of 20 mg/day set by the SCF (1993), as no suitable evidence has emerged since the previous assessment. For children and adolescents, the ARs for vitamin C are extrapolated from the ARs for adults taking into account differences in reference body weight, and PRIs are derived, ranging from 20 mg/day for 1 to 3 year-old children, to 100 and 90 mg/day for boys and girls aged 15-17 years, respectively. For pregnant and lactating women, vitamin C intakes of 10 mg/day and of 60 mg/day in addition to the PRI of non-pregnant non-lactating women are proposed. © European Food Safety Authority, 2013
HIV-1 Tat Protein Chemokine-Related Cytokine) Expression by /Activation-Induced, T Cell-Derived and a (Lymphotactin/Single C Motif-1 Induction of C Chemokine XCL1

HIV-1 Tat has been proposed as a key agent in many AIDS-related disorders, including HIV-1-associated neurological diseases. We have recently shown that Tat expression induces a signiﬁcant increase in T lymphocytes in the brains of Tat transgenic mice. The CNS inﬁltration of T lymphocytes has been noted in AIDS patients. In the present study using this unique genetic system we attempted to understand the underlying mechanisms of Tat expression-induced inﬁltration of T lymphocytes by examining chemokine expression. RNase protection assay revealed that in addition to CCL2 (monocyte chemoattractant protein-1), CCL3 (macrophage inﬂammatory protein-1 (cid:1) (MIP-1 (cid:1) )), CCL4 (MIP-1 (cid:2) ), CCL5 (RANTES), CXCL2 (MIP-2), and CXCL10 (inducing protein-10), XCL1 (lymphotactin/single C motif-1 (cid:1) /activation-induced, T cell-derived and chemokine-related cytokine) was identiﬁed to be up-regulated by Tat expression. XCL1 is a C chemokine and plays a speciﬁc and important role in tissue-speciﬁc recruitment of T lymphocytes. Thus, we further determined the relationship between Tat and XCL1 expression. Tat-induced XCL1 expression was further conﬁrmed by XCL1-speciﬁc RT-PCR and ELISA. Combined in situ hybridization and immunohistochemical staining identiﬁed astrocytes, monocytes, and macrophages/microglia as XCL1-producing cells in vivo. Using human astrocytes, U87.MG cells, as an in vitro model, activation of XCL1 expression was positively correlated with Tat expression. Moreover, the XCL1 promoter-driven reporter gene assay showed that Tat-induced XCL1 expression occurred at the transcriptional level. Taken together, these results demonstrate that Tat directly trans -activated XCL1 expression and suggest potential roles of Tat-induced XCL1 expression in the CNS inﬁltration of T lymphocytes during HIV-1 infection and subsequent HIV-1-induced neurological diseases. The Journal of Immunology, 2004, 172: 1888–1895. CXCL2 and CXCL10; CC chemokines, CCL2, CCL3, CCL4, CCL5, and CCL11; and the C chemokine, XCL1. These results provide direct evidence that the HIV-1 Tat protein is central to the recruitment and extravasation of inﬂammatory cells, such as monocytes/macrophages and T lymphocytes, to the brains of HIV-1 infected individuals and suggest that multiple chemokines are involved in Tat expression-induced CNS inﬁltration of T lymphocytes and monocytes/macrophages.
Classification of all constant solutions of SU(2) Yang–Mills equations with arbitrary current in pseudo-Euclidean space ℝp,q

We present a classification and an explicit form of all constant solutions of the Yang–Mills equations with [Formula: see text] gauge symmetry for an arbitrary constant non-Abelian current in pseudo-Euclidean space [Formula: see text] of arbitrary finite dimension [Formula: see text]. Using hyperbolic singular value decomposition and two-sheeted covering of orthogonal group by spin group, we solve the nontrivial system for constant solutions of the Yang–Mills equations of [Formula: see text] cubic equations with [Formula: see text] unknowns and [Formula: see text] parameters in the general case. We present a new symmetry of this system of equations. All solutions in terms of the potential, strength and invariant of the Yang–Mills field are presented. Nonconstant solutions of the Yang–Mills equations can be considered in the form of series of perturbation theory using all constant solutions as a zeroth approximation.
First-principles calculations of Raman and infrared spectroscopy for phase identification and strain calibration of hafnia

Using density functional perturbation theory, we computed the phonon frequencies and Raman and IR activities of hafnia polymorphs (P42nmc, Pca21, Pmn21, Pbca OI, brookite, and baddeleyite) for phase identification. We investigated the evolution of Raman and IR activities with respect to epitaxial strain and provide plots of frequency differences as a function of strain for experimental calibration and identification of the strain state of the sample. We found Raman signatures of different hafnia polymorphs: [Formula: see text] cm−1 for P42nmc, [Formula: see text] cm−1 for Pca21, [Formula: see text] cm−1 for Pmn21, [Formula: see text] cm−1 for Pbca (OI), [Formula: see text] cm−1 for brookite, and [Formula: see text] cm−1 for baddeleyite. We also identified the Raman [Formula: see text] mode, an anti-phase vibration of dipole moments [[Formula: see text] cm−1 for OI and [Formula: see text] cm−1 for brookite], as the Raman signature of antipolar Pbca structures. We calculated a large splitting between the longitudinal optical and transverse optical modes [[Formula: see text] cm−1 in Pca21 and [Formula: see text] cm−1 in Pmn21] to the same order as those observed in perovskite ferroelectrics and related them to the anomalously large Born effective charges of Hf atoms [[Formula: see text]].
On the Unreasonable Effectiveness of Federated Averaging with Heterogeneous Data

Existing theory predicts that data heterogeneity will degrade the performance of the Federated Averaging (FedAvg) algorithm in federated learning. However, in practice, the simple FedAvg algorithm converges very well. This paper explains the seemingly unreasonable effectiveness of FedAvg that contradicts the previous theoretical predictions. We find that the key assumption of bounded gradient dissimilarity in previous theoretical analyses is too pessimistic to characterize data heterogeneity in practical applications. For a simple quadratic problem, we demonstrate there exist regimes where large gradient dissimilarity does not have any negative impact on the convergence of FedAvg. Motivated by this observation, we propose a new quantity, average drift at optimum, to measure the effects of data heterogeneity, and explicitly use it to present a new theoretical analysis of FedAvg. We show that the average drift at optimum is nearly zero across many real-world federated training tasks, whereas the gradient dissimilarity can be large. And our new analysis suggests FedAvg can have identical convergence rates in homogeneous and heterogeneous data settings, and hence, leads to better understanding of its empirical success.
Long-lived inert Higgs boson in a fast expanding universe and its imprint on the cosmic microwave background

Presence of any extra radiation energy density at the time of cosmic microwave background formation can signiﬁcantly impact the measurement of the eﬀective relativistic neutrino degrees of freedom or ∆N eﬀ which is very precisely measured by the Planck collaboration. Here, we propose a scenario where a long lived inert scalar, which is very weakly coupled to dark sector, decays to a fermion dark matter via freeze-in mechanism plus standard model neutrinos at very low temperature ( T < T BBN ) . We explore this model in the fast expanding universe, where it is assumed that the early epoch ( T > T BBN ) of the Universe is dominated by a non-standard species Φ instead of the standard radiation. In this non-standard cosmological picture, such late time decay of the inert scalar can inject some entropy to the neutrino sector after it decouples from the thermal bath and this will make substantial contribution to ∆N eﬀ . Besides, in this scenario, the new contribution to ∆ N eﬀ is highly correlated with the dark matter sector. Thus, one can explore such feebly interacting dark matter particles (FIMP) by the precise measurement of ∆ N eﬀ using the current (Planck2018) and forthcoming (CMB-S4 & SPT3G) experiments.