Use of Nd: YAG Laser to Recanalize XEN Gel Stent Occluded by Iris Pigment

Dear Editor, The XEN gel stent (Allergan Plc, Dublin, Ireland), developed using biocompatible hydrophilic material, has been spotlighted as a device that can be surgically implanted to effectively control intraocular pressure (IOP) with fewer and less severe postoperative complications compared with conventional glaucoma filtering surgery [1]. However, within a week of XEN gel stent implantation, about 4% of patients experience early-postoperative lumen blockage by blood clot, iris pigment or fibrin [2]. Also, late obstruction can be caused by chronic intraocular inflammation [3]. We describe herein a case of late-postoperative XEN gel stent obstruction by iris pigment that was resolved using the neodymium-doped yttrium aluminum garnet (Nd: YAG) laser. A 54-year-old male underwent XEN gel stent implantation in his left eye for pigmentary glaucoma. Previously the patient had undergone pars plana vitrectomy and trans-scleral fixation of intraocular lens due to intraocular lens dislocation in both eyes. Subsequently, reverse pupillary block occurred in the left eye, and the patient underwent laser peripheral iridotomy. Despite the maximum tolerated medical therapy and selective laser trabeculoplasty, the IOP in the left eye was uncontrolled at 27 mmHg. Implantation of the XEN gel stent was performed in a routine fashion without any intraoperative complications. The day after surgery, the IOP was 2 mmHg, and on slitlamp and gonioscopic examinations, the tip of the XEN gel stent was well positioned at the anterior trabecular meshwork level with the 1+ cell in the anterior chamber (AC). The IOP had gradually normalized to 12 mmHg by postoperative 2 weeks. At 2 months postoperatively, the IOP had increased to 20 mmHg, so bleb needling was performed. After that, the IOP decreased to 12 mmHg. Five months postoperatively, the IOP had increased again to 22 mmHg, and did not respond to digital ocular compression. The 3+ cell was seen in the AC, which was mostly iris pigment, and on slit-lamp and anterior segment optical coherence tomography, lumen blockage of the XEN gel stent at its proximal (AC side) opening was suspected (Fig. 1A-1C). AC irrigation and prophylactic bleb needling with subconjunctival 5-f luorouracil injection (5 mg) was performed, but failed to reduce the IOP. Four shots (total energy 2.2 mJ) of Nd: YAG laser ablation to the proximal end were performed to reopen the lumen, and resultantly, the IOP decreased to 10 mmHg (Fig. 1D-1F), and remained stable 5 months afterwards. There are several previous reports of XEN gel stent lumen blockage. Eagle and Razeghinejad reported proximal-end obstruction by iris pigment, similarly to the current report, but theirs was an instance of early-postoperative obstruction (7 days) in a primary open-angle glaucoma patient for whom the stent was removed surgically [4]. Scantling-Birch et al [2]. reported lumen blockage that was cleared by Nd: YAG laser ablation. According to that report, the lumen was obstructed by fibrin on the day after XEN gel stent implantation combined with phacoemulsification and goniosynechiolysis for primary angle-closure glaucoma. There is also another report, this one of proximal end-lumen blockage by fibrin after XEN-augmented Baerveldt surgery for secondary glaucoma. This blockage, which had occurred 1 month postoperatively, was initially treated by failed YAG-laser fibrinolysis, and subsequently by successful replacement of the stent by a thicker-lumened Baerveldt tube [5]. Korean J Ophthalmol 2021;35(3):):242-243 https://doi.org/10.3341/kjo.2021. 0002