Miracle-dz/UniFAR-FTUs huggingface dataset:
Assessment of multi-mycotoxin contamination throughout the supply chain of maize-based poultry feed from selected regions of Malaysia by LC-MS/MS

Abstract The objective of this study was to examine the occurrence of multi-mycotoxin contamination throughout the supply chain of maize-based poultry feed. Different sampling points throughout the feed supply chain were selected from two companies that manufactured the poultry feed. A total of 51 samples, consisting of grain maize and maize-based poultry feeds, were collected. The samples were analysed by liquid chromatography-tandem mass spectrometry (LC-MS/MS) to determine the occurrence of multi-mycotoxin. The results revealed that 100% of samples throughout the maize-based poultry feed supply chain were spoiled with more than one mycotoxin. Fumonisin B1 (8.02–1,220 µg/kg) and fumonisin B2 (11.1–1,109 µg/kg) were the main mycotoxins detected at all sampling points throughout the feed supply chain. Zearalenone (ZEA) (6.63–7.50 µg/kg) was also detected in 11.7% (n = 6) (out of a total of 51) samples. As the supply chain progresses, a reduction in mycotoxin contamination was observed. Aflatoxins, ochratoxin A (OTA), deoxynivalenol (DON), HT-2, and T-2 toxin were not detected. The levels of mycotoxins detected throughout the supply chain were below the international regulatory limits, thus indicating the low risk of exposure to mycotoxins in maize-based poultry feed in Malaysia. Nevertheless, due to the presence of multiple ingredients in most food and feed, efforts to understand and address challenges associated with mycotoxins throughout the entire supply chain need to be more holistic to protect public health.
243 GHz low-noise amplifier MMICs and modules based on metamorphic HEMT technology

Two compact H-band (220–325 GHz) low-noise millimeter-wave monolithic integrated circuit (MMIC) amplifiers have been developed, based on a grounded coplanar waveguide (GCPW) technology utilizing 50 and 35 nm metamorphic high electron mobility transistors (mHEMTs). For low-loss packaging of the circuits, a set of waveguide-to-microstrip transitions has been realized on 50-μm-thick GaAs substrates demonstrating an insertion loss of <0.5 dB at 243 GHz. By applying the 50 nm gate-length process, a four-stage cascode amplifier module achieved a small-signal gain of 30.6 dB at 243 GHz and more than 28 dB in the bandwidth from 218 to 280 GHz. A second amplifier module, based on the 35-nm mHEMT technology, demonstrated a considerably improved gain of 34.6 dB at 243 GHz and more than 32 dB between 210 and 280 GHz. At the operating frequency, the two broadband low-noise amplifier modules achieved a room temperature noise figure of 5.6 dB (50 nm) and 5.0 dB (35 nm), respectively.
Bilateral absence of the fibular artery: an unusual variation

We read the article with interest by Feng et al. on the branching variation of the popliteal artery. And, we would like to express our different views. The authors described a rare case in which the popliteal artery bifurcated into the anterior tibial artery and the posterior tibial artery. They believed that the bilateral peroneal arteries were absent and did not belong to any category of Kim’s classification. However, we believe that the popliteal artery branch variant should belong to type IIIA, that is, the posterior tibial artery is congenital hypoplastic or aplastic and the peroneal artery is large. Firstly, the picture in the article showed that the posterior tibial artery descended between the tibia and fibula. At the ankle, the artery gradually turned to the inside and extended into the plantar artery. The anatomical variation described here are completely consistent with the type IIIA variation. Secondly, angiography of the lower extremity was not performed to this case, and computed tomography angiography (CTA) was obviously not sensitive enough to visualize the collateral arteries. Bellezza et al. reported a case of congenital absence of the posterior tibial artery. Through lower extremity angiography, it was clear that the popliteal artery bifurcated into the anterior tibial artery and the peroneal artery, and the distal peroneal artery extended into the plantar artery. Calisir et al. also clearly demonstrated the type IIIA variation of the popliteal artery through CTA three-dimensional imaging. Both of them are consistent with the type of popliteal artery variation described by Feng et al. Therefore, we have sufficient reason to believe that the popliteal artery branching variation in this case is type IIIA. We look forward to their reply and further communication.
Stability and Change in Asexuality: Relationship Between Sexual/Romantic Attraction and Sexual Desire

ABSTRACT This study examined the stability and change in asexuality in terms of sexual orientation identity, sexual/romantic attraction, and sexual desire. Data were collected in three waves at 12-month intervals (n = 168). In each wave, the participants completed measures of sexual/romantic orientation identity, sexual/romantic attraction, the Sexual Desire Inventory, and the Asexuality Identification Scale (AIS). Approximately 83% of asexual and gray-asexual individuals maintained their sexual orientation identity between two adjacent waves. The latent growth models indicated an increased tendency for sexual/romantic attraction and solitary sexual desire, while a decreased tendency for AIS over time was established. Only the sexual attraction slope significantly predicted asexual identity, indicating a longitudinal effect of sexual attraction on asexual identification. Initial levels of sexual attraction, and scores on the AIS and dyadic sexual desire (DSD) were associated with stability and changes in asexual identity. Asexual individuals who reported low sexual attraction, low DSD, and high AIS maintained their asexual identity, whereas those who reported high sexual attraction, high DSD, and low AIS were more likely to change their sexual orientation. The current findings indicate the relative stability of asexuality, which supports the notion that asexuality could be deemed a fourth sexual orientation.
Rehabilitation for Total Hip Arthroplasty

Abstract We sought to determine the comparative benefits and harms of rehabilitation interventions for patients who have undergone elective, unilateral THA surgery for the treatment of primary osteoarthritis. We searched PubMed, Embase, The Cochrane Register of Clinical Trials, CINAHL, PsycINFO, Scopus, and ClinicalTrials.gov from January 1, 2005, through May 3, 2021. We included randomized controlled trials and adequately adjusted nonrandomized comparative studies of rehabilitation programs reporting performance-based, patient-reported, or healthcare utilization outcomes. Three researchers extracted study data and assessed risk of bias, verified by an independent researcher. Experts in rehabilitation content and complex interventions independently coded rehabilitation interventions. The team assessed strength of evidence. Large heterogeneity across evaluated rehabilitation programs limited conclusions. Evidence from 15 studies suggests that diverse rehabilitation programs may not differ in terms of risk of harm or outcomes of pain, strength, activities of daily living, or quality of life (all low strength of evidence). Evidence is insufficient for other outcomes. In conclusion, no differences in outcomes were found between different rehabilitation programs after THA. Further evidence is needed to inform decisions on what attributes of rehabilitation programs are most effective for various outcomes.
Effect of High-Intensity Interval Treadmill Exercise on Subsequent Lower and Upper Limb Strength Performance

ABSTRACT Purpose: The aim of this study was to analyze the acute effect of a treadmill high-intensity interval protocol on subsequent upper body and lower body strength exercise performance. Method: Sixteen young men had their maximal aerobic capacity and one-repetition maximum (1RM) determined and underwent four randomized conditions: a half-squat control session; a bench press control session; a treadmill interval protocol followed by a half-squat experimental session; and a treadmill interval protocol followed by a bench press experimental session. During the control sessions, four sets to failure for each exercise were performed at 80% of 1RM. In the experimental sessions, participants performed eight sprints of 40 s at 100% velocity of maximal oxygen uptake with 20 s of passive interval between them, followed by the same strength exercise protocol of the control sessions. The number of repetitions during each protocol and participants’ heart rate (HR),and blood lactate concentration ([lac]) were compared pre and post protocols and exercises. Results: Fewer repetitions were completed in the experimental session compared to the control sessions (p < .001). Moreover, the reduction in number of repetitions performed was more evident in half-squat compared to bench press (p = .018). HR was higher at the end of sessions with the interval protocol for both exercises (p < .001). The [lac] was higher at the end of session with the interval protocol for half-squat (p = .003). Conclusions: These findings suggest that previous high-intensity interval running may impair subsequent strength exercise performance, but the magnitude of the negative effect is greater in the lower limbs.
Improved stability and skin penetration through glycethosomes loaded with glycyrrhetinic acid

In recent years, glycyrrhetinic acid (GA) has been popularly used in cosmetics because of its anti‐inflammatory and anti‐oxidant effects. However, due to the poor water solubility of GA and the barrier effect of human skin, the penetration of GA through the skin may be hindered. Liposomes are a common delivery system for functional compounds in cosmetics. Nonetheless, the stability and transdermal effect of traditional liposomes are limited. The aim of this work was to prepare a new liposome system that contained glycerol and ethanol to enhance the stability of the vesicles and promote the penetration of GA into the skin.
Vocabulary Growth in Mandarin-Speaking Children With Bilateral Cochlear Implants, Bimodal Stimulation, or Unilateral Cochlear Implants During the First Year After Activation.

PURPOSE The purpose of this study was to evaluate vocabulary development in Mandarin-speaking children with bilateral cochlear implants (CIs), bimodal stimulation (CI plus hearing aids [HAs]), or unilateral CIs during the first year after CI activation. METHOD Participants included 23 children with simultaneous bilateral CIs, 23 children with bimodal stimulation, and 15 children with unilateral CIs. They all received CIs before 30 months of age. Parents were asked to endorse words that their child could understand only or understand and say using the Early Vocabulary Inventory for Mandarin Chinese at the day of CI activation and 1, 3, 6, 9, and 12 months after CI activation. Receptive and expressive vocabulary sizes were computed. RESULTS Growth curve analysis revealed that children with simultaneous bilateral CIs demonstrated faster growth of receptive vocabulary than those with bimodal stimulation, followed by those with unilateral CIs. Moreover, children with simultaneous bilateral CIs reached the 100-word mark for receptive vocabulary earlier than children with bimodal stimulation, followed by those with unilateral CIs. There were no significant differences among the three groups in expressive vocabulary. CONCLUSIONS Bilateral CIs have an advantage over bimodal stimulation in early receptive vocabulary development in Mandarin, a tone language. HA usage is still recommended for those who receive one CI.
Physicochemical investigation of a novel curcumin diethyl γ-aminobutyrate, a carbamate ester prodrug of curcumin with enhanced anti-neuroinflammatory activity

Curcumin is a polyphenol compound that alleviates several neuroinflammation-related diseases including Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, epilepsy and cerebral injury. However, the therapeutic efficacy of curcumin is limited by its poor physicochemical properties. The present study aimed to develop a new carrier-linked curcumin prodrug, curcumin diethyl γ-aminobutyrate (CUR-2GE), with improved physicochemical and anti-neuroinflammatory properties. CUR-2GE was designed and synthesized by conjugating curcumin with gamma-aminobutyric acid ethyl ester (GE) via a carbamate linkage. The carbamate linkage was selected to increase stability at acidic pH while GE served as a promoiety for lipophilic enhancement. The synthesized CUR-2GE was investigated for solubility, partition coefficient, stability, and bioconversion. The solubility of CUR-2GE was less than 0.05 μg/mL similar to that of curcumin, while the lipophilicity with log P of 3.57 was significantly increased. CUR-2GE was resistant to chemical hydrolysis at acidic pH (pH 1.2 and 4.5) as anticipated but rapidly hydrolyzed at pH 6.8 and 7.4. The incomplete hydrolysis of CUR-2GE was observed in simulated gastrointestinal fluids which liberated the intermediate curcumin monoethyl γ-aminobutyric acid (CUR-1GE) and the parent curcumin. In plasma, CUR-2GE was sequentially converted to CUR-1GE and curcumin within 1 h. In lipopolysaccharide (LPS)-stimulated BV-2 microglial cells, CUR-2GE effectively attenuated the pro-inflammatory mediators by decreasing the secretion of nitric oxide and cytokines (TNF-α and IL-6) to a greater extent than curcumin due to an increase in cellular uptake. Altogether, the newly developed acid-stable CUR-2GE prodrug is a potential pre-clinical and clinical candidate for further evaluation on neuroprotective and anti-neuroinflammatory effects.
The use of spider webs in the monitoring of air quality—A review

Methods for using spider webs as passive air samplers have been developed over recent years and reported in more than a dozen articles. In this article, we present the typical procedures followed when using this new tool and critically review its application in air pollution assessment. To understand the state of research and application of spider webs in this field, we describe some advantages and disadvantages of their use in the analyses of air contaminants. The aim is to summarize the current knowledge on this subject, highlight gaps in the present studies, and arouse the interest of scientists on this issue. The increased effort could result in the standardization of the method at the national and international level. Integr Environ Assess Manag 2023;19:32–44. © 2022 SETAC
Gepo with a G, or Jepo with a J? Skilled Readers Generate Orthographic Expectations for Novel Spoken Words Even When Spelling is Uncertain

Abstract English‐speaking children and adults generate orthographic skeletons (i.e., preliminary orthographic representations) solely from aural exposure to novel words. The present study examined whether skilled readers generate orthographic skeletons for all novel words they learn or do so only when the words have a unique possible spelling. To that end, 48 Spanish adults first provided their preferred spellings for all novel words that were to appear in the experiment. Critically, consistent words had only one, while inconsistent words had two possible spellings. Two weeks later, they were trained on the pronunciations of the novel words through aural instruction. They then saw the spellings of these newly acquired words, along with a set of untrained words, in a self‐paced sentence reading task. Participants read previously acquired consistent and inconsistent words presented in their preferred spellings faster than inconsistent words with unpreferred spellings. Importantly, no differences were observed in reading untrained consistent and inconsistent words (either preferred or unpreferred). This suggests that participants had generated orthographic skeletons for trained words with two possible spellings according to their individual spelling preferences. These findings provide further evidence for the orthographic skeleton account and show that initial orthographic representations are generated even when the spelling of a newly acquired word is uncertain.
A Specific Calprotectin Neo-epitope [CPa9-HNE] in Serum from Inflammatory Bowel Disease Patients Is Associated with Neutrophil Activity and Endoscopic Severity

Abstract Background and Aims Endoscopy and the use of faecal calprotectin [faecal CP] are among the least-favoured methods for assessing disease activity by inflammatory bowel disease [IBD] patients; the handling/processing of faecal samples is also impractical. Therefore, we sought to develop a novel neo-epitope serum calprotectin enzyme-linked immunosorbent assay [ELISA], CPa9-HNE, with the aim of quantifying neutrophil activity and neutrophil extracellular trap [NET]-osis and proposing a non-invasive method for monitoring disease activity in IBD patients. Methods In vitro cleavage was performed by mixing calprotectin [S100A9/S100A8] with human neutrophil elastase [HNE], and a novel HNE-derived calprotectin neo-epitope [CPa9-HNE] was identified by mass spectrometry for ELISA development. The CPa9-HNE ELISA was quantified in supernatants from ex vivo activated neutrophils and serum samples from patients with ulcerative colitis [UC, n = 43], Crohn’s disease [CD, n = 93], and healthy subjects [HS, n = 23]. For comparison, faecal CP and MRP8/14 biomarkers were also measured. Results CPa9-HNE was specific for activated neutrophils ex vivo. Serum CPa9-HNE levels were 4-fold higher in CD [p <0.0001] and UC [p <0.0001] patients than in HS. CPa9-HNE correlated well with the Simple Endoscopic Score [SES]-CD score [r = 0.61, p <0.0001], MES [r = 0.46, p = 0.0141], and the full Mayo score [r = 0.52, p = 0.0013]. CPa9-HNE was able to differentiate between CD and UC patients in endoscopic remission and moderate/severe disease activity (CD: area under the curve [AUC] = 0.82 [p = 0.0003], UC: AUC = 0.87 [p = 0.0004]). The performance of CPa9-HNE was equipotent or slightly better than that of faecal CP. Conclusions Serum CPa9-HNE levels were highly associated with CD and UC patients. CPa9-HNE correlated with the SES-CD score and the full Mayo score, indicating a strong association with disease activity.
Character strengths and fluid intelligence

Abstract Objective Research on the associations between cognitive and noncognitive personality traits has widely neglected character strengths, that means positively and morally valued personality traits that constitute good character. Method The present study aimed to bridge this gap by studying the associations between character strengths and fluid intelligence using different operationalizations of character strengths (including self‐ and informant‐reports) and fluid intelligence in children, adolescents, and adults. Results The results, based on four samples (N = 193/290/330/324), suggested that morally valued personality traits are independent of fluid intelligence, with the exception of love of learning, which showed small but robust positive relationships with fluid intelligence across all samples. Conclusions Nonetheless, we argue for further research on the associations with other cognitive abilities and interactions between character strengths and intelligence when examining their relationships with external criteria.
Slick Potassium Channels Control Pain and Itch in Distinct Populations of Sensory and Spinal Neurons in Mice

Background: Slick, a sodium-activated potassium channel, has been recently identified in somatosensory pathways, but its functional role is poorly understood. The authors of this study hypothesized that Slick is involved in processing sensations of pain and itch. Methods: Immunostaining, in situ hybridization, Western blot, and real-time quantitative reverse transcription polymerase chain reaction were used to investigate the expression of Slick in dorsal root ganglia and the spinal cord. Mice lacking Slick globally (Slick–/–) or conditionally in neurons of the spinal dorsal horn (Lbx1-Slick–/–) were assessed in behavioral models. Results: The authors found Slick to be enriched in nociceptive Aδ-fibers and in populations of interneurons in the spinal dorsal horn. Slick–/– mice, but not Lbx1-Slick–/– mice, showed enhanced responses to noxious heat in the hot plate and tail-immersion tests. Both Slick–/– and Lbx1-Slick–/– mice demonstrated prolonged paw licking after capsaicin injection (mean ± SD, 45.6 ± 30.1 s [95% CI, 19.8 to 71.4]; and 13.1 ± 16.1 s [95% CI, 1.8 to 28.0]; P = 0.006 [Slick–/– {n = 8} and wild-type {n = 7}, respectively]), which was paralleled by increased phosphorylation of the neuronal activity marker extracellular signal–regulated kinase in the spinal cord. In the spinal dorsal horn, Slick is colocalized with somatostatin receptor 2 (SSTR2), and intrathecal preadministration of the SSTR2 antagonist CYN-154806 prevented increased capsaicin-induced licking in Slick–/– and Lbx1-Slick–/– mice. Moreover, scratching after intrathecal delivery of the somatostatin analog octreotide was considerably reduced in Slick–/– and Lbx1-Slick–/– mice (Slick–/– [n = 8]: 6.1 ± 6.7 bouts [95% CI, 0.6 to 11.7]; wild-type [n =8]: 47.4 ± 51.1 bouts [95% CI, 4.8 to 90.2]; P = 0.039). Conclusions: Slick expressed in a subset of sensory neurons modulates heat-induced pain, while Slick expressed in spinal cord interneurons inhibits capsaicin-induced pain but facilitates somatostatin-induced itch. Using male and female mouse models, it was observed that Slick reduces responses to noxious thermal and chemical stimulation. Conversely, Slick expressed on spinal interneurons facilitates somatostatin-induced itch. Analgesics targeting Slick channels may decrease pain but could increase itching if they reach the central nervous system.
Enhancing ionic conductivity in solid electrolyte by relocating diffusion ions to under-coordination sites

Solid electrolytes are highly important materials for improving safety, energy density, and reversibility of electrochemical energy storage batteries. However, it is a challenge to modulate the coordination structure of conducting ions, which limits the improvement of ionic conductivity and hampers further development of practical solid electrolytes. Here, we present a skeleton-retained cationic exchange approach to produce a high-performance solid electrolyte of Li3Zr2Si2PO12 stemming from the NASICON-type superionic conductor of Na3Zr2Si2PO12. The introduced lithium ions stabilized in under-coordination structures are facilitated to pass through relatively large conduction bottlenecks inherited from the Na3Zr2Si2PO12 precursor. The synthesized Li3Zr2Si2PO12 achieves a low activation energy of 0.21 eV and a high ionic conductivity of 3.59 mS cm−1 at room temperature. Li3Zr2Si2PO12 not only inherits the satisfactory air survivability from Na3Zr2Si2PO12 but also exhibits excellent cyclic stability and rate capability when applied to solid-state batteries. The present study opens an innovative avenue to regulate cationic occupancy and make new materials.
Psychological homeostasis and protective behaviours in the COVID-19 pandemic

Since the first case of human SARS-CoV-2 infection late in 2019 workers across multiple disciplines have been strenuously engaged in attempting to prevent the spread of the virus and to provide care to patients. Never in history has so much human effort been concentrated on a single health trauma. Much of the new research is empirical in nature with relatively few strands of theory. This article focuses on two recent theories relevant to COVID-19 protective behaviours, the COM-B and the General Theory of Behaviour. New empirical findings on the means, motives and opportunities for COVID-19 protective behaviours improve our knowledge and capacity to cope with pandemics using psychological homeostasis.