Miracle-dz/UniFAR-FTUs huggingface dataset:
microRNA Levels in Cervical Cancer Samples and Relationship with Lesion Grade and HPV Infection.

BACKGROUND miR-21, miR-214, and miR-let-7a are three validated and well-known miRNAs. miR-21 is described as an "oncomir," while miR-214 and miR-let-7a are described mainly as tumor suppressors. The role of these miRNAs remains unclear in cervical cancer, an important malignancy among women worldwide and responsible for many deaths every year. OBJECTIVE The objective of this study was to describe the expression profile of miR-21, miR-214, and miR-let-7a in plasma and cervical scraping from a control group and patients with different grades of cervical lesions and invasive cervical cancer, and then correlate with HPV infection groups. METHODS Plasma and cervical scraping were submitted to DNA and RNA extraction. HPV detection and typing were performed by conventional PCR followed by PAGE to amplicons interpretation. The miRNA relative expression in plasma and cervical scraping samples was performed by real-time PCR using specific TaqMan probes. RESULTS miR-21 (p=0.0277) and miR-214 (p=0.0151) were up-regulated in cervical scraping samples of the invasive cervical cancer (ICC) group. However, miR-214 was also up-regulated in the LSIL group (p=0.0062). Both miRNAs were not related to HPV infection. However, miR-let-7a was higher in HPV positive plasma samples (p=0.0433) than in HPV negative plasma samples, and the correlation analysis confirmed the association between the levels of this miRNA with the presence of HPV (p=0.0407; r=0.3029), but not with lesion grade (p>0.05). CONCLUSION Our results suggest that miR-21 is related to cervical cancer progression and miR-214 appears to have an ambiguous role in cervical lesions. miR-let-7a may be upregulated at the systemic level in patients with HPV infection.
The Economic Influence on Consumers Buying Behavior in Islamic Countries: Evidence from the COVID-19 Economic Crisis

Abstract The Covid-19 pandemic has ushered in a new age in the world. We are still grappling with the implications in various areas of our everyday lives. The impulsive buying habits of consumers, the supply chain, and the whole industry are not exceptions. Consumers and supply chains were both unprepared during the early stages of the novel coronavirus pandemic. The procurement of utilitarian products was referred to as panic buying. The study examined using exploratory studies on several individuals in the eight selected Islamic countries who have been panic buying in coronavirus-affected areas and have faced regional constraints. The data apply on exploratory factor analysis (EFA) in eight selected Islamic countries, three hundred sample finally selected, and a good number of volunteers supported in this study. The results have shown that a drastic financial effect on the economy where purchasing power and remittance inflow declined, inflation goes up and precaution for lockdown, whereas impulsive buying goods tendency increased due to misinformation, and panic buying immensely impact in the economy. The decision-making process has shifted, preventing financial burdening, rising saving patterns, and unwelcoming unhealthy consumption. Moreover, visible psychological distress, depression, anxiety, and post-traumatic stress. These studies concluded with a policy recommendation providing the results.
The efficacy of botulinum toxin A treatment for tension-type or cervicogenic headache: a systematic review and meta-analysis of randomized, placebo-controlled trials

Abstract Objectives The pathogeneses of chronic tension-type headache (CTTH) and cervicogenic headache (CEH) are not well established. Peripheral activation or sensitization of myofascial nociceptors is suggested as a potential mechanism and injections of botulinum toxin (BONTA) have thus been used in the treatment for both headache conditions. BONTA inhibits the release of acetylcholine at the neuromuscular junction and inhibits contraction of skeletal muscles. If the pain is precipitated by increased tone in cervical muscles, local injections of BONTA could represent a prophylactic measure. However, the treatment is still controversial, and a thorough assessment of the current evidence is required. This review aims to assess the evidence of BONTA injection as a prophylactic treatment for CTTH and CEH by reviewing and examining the quality of placebo-controlled, randomized trials. Methods Data sources: we searched in the following databases: PubMed (including Medline), Embase, Cochrane Central register of Controlled Trials, Cinahl, Amed, SCOPUS and Google Scholar including other repository sources. Both MeSH and free keywords were used in conducting the systematic search in the databases. The search covered publications from the root of the databases to November 2020. Study eligibility criteria The review included RCTs, comparing single treatment of BONTA with placebo on patients with CTTH or CEH above 18 years of age, by measuring pain severity/relief or headache frequency. Data extraction The following data were extracted: year of publication, country, setting, trial design, number of participants, injection procedure, BONTA dosages, and clinical outcome measures. Study appraisal To assess validity and quality, and risk of bias, the Oxford Pain Validity Scale, Modified Jadad Scale, last version of Cochrane Collaboration’s tool for assessing risk of bias (RoB 2), and the CONSORT 2010 Checklist were used. The trials were assessed, and quality scored independently by two of the reviewers. A quantitative synthesis and meta-analyses of headache frequency and intensity were performed. Results We extracted 16 trials, 12 on prophylactic BONTA treatment for CTTH and four on CEH. Of these 12 trials (8 on CTTH and 4 on CEH) were included in the quantitative synthesis. A majority of the trials found no significant difference on the primary outcome measure when BONTA treatment was compared with placebo. Three “positive” trials, reporting significant difference in favor of BONTA treatment, but two of these were hampered by low validity and quality scores and high risk of bias. Conclusions There is no clear clinical evidence supporting prophylactic treatment with BONTA for CTTH or CEH.
The structure of unemployment risk perception among migrant workers in China: An exploratory mixed methods study

China has 287 million migrant workers and identifying and preventing their unemployment risk holds theoretical and practical significance. This study collected data in 2019 to explore the structure of migrant workers’ perception of unemployment risk. In the first stage of this study, in-depth interviews and grounded theory analysis were conducted and an interpretation framework for migrant workers’ unemployment risk perception (URP) was developed. In the second stage, a URP scale for migrant workers was developed and then tested and verified using a questionnaire survey and factor analysis. The results showed that the URP of migrant workers is composed of many dimensions: mental, financial, relationship, citizenization and re-migration.
Why Do Taiwanese Consumers Purchase Korean Beauty Product?

This research aims to explore and examine factors influencing Taiwan consumers on repurchase intention of Korean beauty products. A causal study design is used in this research to establish a cause-and-effect relationship between each construct. Questionnaires were distributed to beauty product consumers in Taiwan. A total of 241 usable questionnaires are used for this study. Moreover, SEM was applied for data analysis and testing the model. There is a cause-and-effect relationship between product design, promotion, product price, brand name and repurchase intention. Product price and brand name significantly influence customer repurchase intention. This research suggests practical directions for companies to consider and address product design, promotion, product price, and brand name to achieve customer retention and customer repurchase intention.
Optimizing One-time and Continuous Subgraph Queries using Worst-case Optimal Joins

We study the problem of optimizing one-time and continuous subgraph queries using the new worst-case optimal join plans. Worst-case optimal plans evaluate queries by matching one query vertex at a time using multiway intersections. The core problem in optimizing worst-case optimal plans is to pick an ordering of the query vertices to match. We make two main contributions: 1. A cost-based dynamic programming optimizer for one-time queries that (i) picks efficient query vertex orderings for worst-case optimal plans and (ii) generates hybrid plans that mix traditional binary joins with worst-case optimal style multiway intersections. In addition to our optimizer, we describe an adaptive technique that changes the query vertex orderings of the worst-case optimal subplans during query execution for more efficient query evaluation. The plan space of our one-time optimizer contains plans that are not in the plan spaces based on tree decompositions from prior work. 2. A cost-based greedy optimizer for continuous queries that builds on the delta subgraph query framework. Given a set of continuous queries, our optimizer decomposes these queries into multiple delta subgraph queries, picks a plan for each delta query, and generates a single combined plan that evaluates all of the queries. Our combined plans share computations across operators of the plans for the delta queries if the operators perform the same intersections. To increase the amount of computation shared, we describe an additional optimization that shares partial intersections across operators. Our optimizers use a new cost metric for worst-case optimal plans called intersection-cost. When generating hybrid plans, our dynamic programming optimizer for one-time queries combines intersection-cost with the cost of binary joins. We demonstrate the effectiveness of our plans, adaptive technique, and partial intersection sharing optimization through extensive experiments. Our optimizers are integrated into GraphflowDB.
Ultrasound Medical Imaging Techniques

Ultrasound (US) imaging for medical purposes has been increasing in popularity over the years. The US technology has some valuable strengths, such as it is harmless, very cheap, and can provide real-time feedback. At the same time, it has also some drawbacks that the research in this field is trying to mitigate, such as the high level of noise and the low quality of the images. This survey aims at presenting the advances in the techniques used for US medical imaging. It describes the studies on the different organs that the US uses the most and tries to categorize the research in this field into three groups, i.e., segmentation, classification, and miscellaneous. This latter group includes the works that either provide aid during surgical operations or try to enhance the quality of the acquired US images/volumes. To the best of our knowledge, this is the first review that analyzes the different techniques exploited on a large selection of body locations (i.e., brain, thyroid, heart, breast, fetal, and prostate) in the three sub-fields of research.
The case for adding privacy-related offloading to smart storage

It is important to ensure that personally identifiable information (PII) is protected within large distributed systems and is used only for intended purposes. Achieving this is challenging and several techniques have been proposed for privacy-preserving analytics, but they typically focus on the end hosts only. We argue that future storage solutions should include, in addition to emerging compute offload, also privacy-related operators. Since many privacy operators, such as perturbation and anonymization, take place as the very first step before other computations, query offload to a Smart Storage device might be only feasible in the future if privacy-related operators can also be offloaded. In this work we demonstrate that privacy-preserving operators can be implemented in hardware without reducing read bandwidths. We focus on perturbations and extend an FPGA-based network-attached Smart Storage solution to show that it is possible to provide these operations at 10Gbps line-rate while using only a small amount of additional FPGA real-estate. We also discuss how future faster smart storage nodes should look like in the light of these additional requirements.
An Analysis of Fraud Hexagon in Detecting Financial Statement Fraud (Empirical Study of Listed Banking Companies on Indonesia Stock Exchange for Period 2017 – 2019)

Cases of fraud are increasing from year to year. The most costly type of fraud is financial statement fraud. This kind of fraud causes substantial losses for the company and users of financial statement. The aim of this research is to analyze fraud hexagon in detecting financial statement fraud of banking companies listed on Indonesia Stock Exchange for the period 2017-2019. The research population is 46 banking companies listed in Indonesia Stock Exchange. Purposive sampling method is used on this research. The sample chosen with matching criteria is 41 companies with a total observation of 123. Logistic regression method is used to analyze data. The research results indicated that the financial target, external pressure, ineffective monitoring, change in auditor, change in director, and frequent number of CEO's picture do not have an effect in detecting financial statement fraud on listed banking companies. Meanwhile, collusion has an effect in detecting financial statement fraud on listed banking companies.
The Effect of Deferred Tax Expenses on Earning Management in Banking Companies

This study aims to determine the effect of deferred tax expense on earnings management in banking companies. This study uses secondary data which is analyzed and obtained from financial reports or annual reports of companies listed on the Indonesia Stock Exchange. Methods of data analysis using linear regression analysis using SPSS software. The results showed that deferred tax expense has an effect on earnings management. If a deferred tax asset arises intentionally or at the desire of management, it can be estimated that the realization will be carried out in the planned period in order to increase the company's profits in that period.
S2Dedup: SGX-enabled secure deduplication

Secure deduplication allows removing duplicate content at third-party storage services while preserving the privacy of users' data. However, current solutions are built with strict designs that cannot be adapted to storage service and applications with different security and performance requirements. We present S2Dedup, a trusted hardware-based privacy-preserving deduplication system designed to support multiple security schemes that enable different levels of performance, security guarantees and space savings. An in-depth evaluation shows these trade-offs for the distinct Intel SGX-based secure schemes supported by our prototype. Moreover, we propose a novel Epoch and Exact Frequency scheme that prevents frequency analysis leakage attacks present in current deterministic approaches for secure deduplication while maintaining similar performance and space savings to state-of-the-art approaches.
Modelling the effects of bioclimatic characteristics and climate change on the potential distribution of a monospecific species Colophospermum mopane (Benth.) Léonard in southern Africa

Global climate change is gradually changing species distribution and their patterns of diversity. Yet, factors that influence the local distribution and habitat preferences for southern African species remain largely unexplored. Here, we computed the suitable habitats in the southern African region for Colophospermum mopane (Benth.) using the maximum entropy (Maxent) modeling approach. We utilized one Global Circulation Model (GCM) and three Representative concentration pathways (RCPs) to determine the current and future distribution of C. mopane. The results showed that the distribution of C. mopane was mainly influenced by solar radiation, annual temperature range, and annual precipitation. According to the species response curves, this species preferred habitats with annual precipitation of 130-200 mm, an annual temperature range of 28° C, and elevations of about 500 m above sea level. The results highlight that the geographic range of C. mopane is likely to expand along the borders of Zambia and Zimbabwe in the future, particularly in the miombo plains. Conversely, suitable habitat areas reduce significantly in the eastern area of the southern African region, while the western areas expand. Overall, the appropriate habitat areas will likely decline in the 2050s under both RCPs and expand in the 2070s under the two scenarios. This knowledge is important for landscape planners and rangeland managers working to safeguard biodiversity from extinction. Highlights High reliability of models in habitat suitability modelling for C. mopane Solar radiation is the most significant variable for the current distribution of mopane. Climate change is and will reduce the habitat suitability of our target species.
Enteric Coronavirus Infection and Treatment Modeled With an Immunocompetent Human Intestine-On-A-Chip

Many patients infected with coronaviruses, such as SARS-CoV-2 and NL63 that use ACE2 receptors to infect cells, exhibit gastrointestinal symptoms and viral proteins are found in the human gastrointestinal tract, yet little is known about the inflammatory and pathological effects of coronavirus infection on the human intestine. Here, we used a human intestine-on-a-chip (Intestine Chip) microfluidic culture device lined by patient organoid-derived intestinal epithelium interfaced with human vascular endothelium to study host cellular and inflammatory responses to infection with NL63 coronavirus. These organoid-derived intestinal epithelial cells dramatically increased their ACE2 protein levels when cultured under flow in the presence of peristalsis-like mechanical deformations in the Intestine Chips compared to when cultured statically as organoids or in Transwell inserts. Infection of the intestinal epithelium with NL63 on-chip led to inflammation of the endothelium as demonstrated by loss of barrier function, increased cytokine production, and recruitment of circulating peripheral blood mononuclear cells (PMBCs). Treatment of NL63 infected chips with the approved protease inhibitor drug, nafamostat, inhibited viral entry and resulted in a reduction in both viral load and cytokine secretion, whereas remdesivir, one of the few drugs approved for COVID19 patients, was not found to be effective and it also was toxic to the endothelium. This model of intestinal infection was also used to test the effects of other drugs that have been proposed for potential repurposing against SARS-CoV-2. Taken together, these data suggest that the human Intestine Chip might be useful as a human preclinical model for studying coronavirus related pathology as well as for testing of potential anti-viral or anti-inflammatory therapeutics.
AR-V7 exhibits non-canonical mechanisms of nuclear import and chromatin engagement in castrate-resistant prostate cancer

Expression of the AR splice variant, AR-V7, in prostate cancer is correlated with poor patient survival and resistance to AR targeted therapies and taxanes. Currently, there is no specific inhibitor of AR-V7, while the molecular mechanisms regulating its biological function are not well elucidated. Here we report that AR-V7 has unique biological features that functionally differentiate it from canonical AR-fl or from the second most prevalent variant, AR-v567. First, AR-V7 exhibits fast nuclear import kinetics via a pathway distinct from the nuclear localization signal dependent importin-α /β pathway used by AR-fl and AR-v567. We also show that the dimerization box domain, known to mediate AR dimerization and transactivation, is required for AR-V7 nuclear import but not for AR-fl. Once in the nucleus, AR-V7 is transcriptionally active, yet exhibits unusually high intranuclear mobility and transient chromatin interactions, unlike the stable chromatin association of liganded AR-fl. The high intranuclear mobility of AR-V7 together with its high transcriptional output, suggest a Hit-and-Run mode of transcription. Our findings reveal unique mechanisms regulating AR-V7 activity, offering the opportunity to develop selective therapeutic interventions.
The RNA Helicase Ded1 Regulates Translation and Granule Formation during Multiple Phases of Cellular Stress Responses

Ded1 is a conserved RNA helicase that promotes translation initiation in steady-state conditions. Ded1 has also been shown to regulate translation during cellular stress and affect the dynamics of stress granules (SGs), accumulations of RNA and protein linked to translation repression. To better understand its role in stress responses, we examined Ded1 function in two different models: DED1 overexpression and oxidative stress. DED1 overexpression inhibits growth and promotes the formation of SGs. ABSTRACT Ded1 is a conserved RNA helicase that promotes translation initiation in steady-state conditions. Ded1 has also been shown to regulate translation during cellular stress and affect the dynamics of stress granules (SGs), accumulations of RNA and protein linked to translation repression. To better understand its role in stress responses, we examined Ded1 function in two different models: DED1 overexpression and oxidative stress. DED1 overexpression inhibits growth and promotes the formation of SGs. A ded1 mutant lacking the low-complexity C-terminal region (ded1-ΔCT), which mediates Ded1 oligomerization and interaction with the translation factor eIF4G1, suppressed these phenotypes, consistent with other stresses. During oxidative stress, a ded1-ΔCT mutant was defective in growth and in SG formation compared to wild-type cells, although SGs were increased rather than decreased in these conditions. Unlike stress induced by direct TOR inhibition, the phenotypes in both models were only partially dependent on eIF4G1 interaction, suggesting an additional contribution from Ded1 oligomerization. Furthermore, examination of the growth defects and translational changes during oxidative stress suggested that Ded1 plays a role during recovery from stress. Integrating these disparate results, we propose that Ded1 controls multiple aspects of translation and RNP dynamics in both initial stress responses and during recovery.
Transsaccadic integration operates independently in different feature dimensions

Our knowledge about objects in our environment reflects an integration of current visual input with information from preceding gaze fixations. Such a mechanism may reduce uncertainty, but requires the visual system to determine which information obtained in different fixations should be combined or kept separate. To investigate the basis of this decision, we conducted three experiments. Participants viewed a stimulus in their peripheral vision, then made a saccade that shifted the object into the opposite hemifield. During the saccade, the object underwent changes of varying magnitude in two feature dimensions (Experiment 1: color and location, Experiments 2 and 3: color and orientation). Participants reported whether they detected any change and estimated one of the post-saccadic features. Integration of pre-saccadic with post-saccadic input was observed as a bias in estimates towards the pre-saccadic feature value. In all experiments, pre-saccadic bias weakened as the magnitude of the transsaccadic change in the estimated feature increased. Changes in the other feature, despite having a similar probability of detection, had no effect on integration. Results were quantitatively captured by an observer model where the decision whether to integrate information from sequential fixations is made independently for each feature and coupled to awareness of a feature change.