Miracle-dz/UniFAR-FTUs huggingface dataset:
Alternative protein innovations and challenges for industry and consumer: an initial overview

Over one fourth of today's greenhouse gas emissions are the result of agriculture, with the production of meat representing a large portion of this carbon footprint. As the wealth of low- and middle-income countries continues to increase, the demand for animal-sourced protein, such as dairy and meat products, will escalate. At this point in time, livestock feed alone utilizes almost 40% of the world's cropland. The rapidly increasing world population, coupled with a need for environmental sustainability, has renewed our attention on animal-protein substitutes. Apprehensions over climate change have aided an acceleration in the research and development of alternative proteins, which may replace some animal-sourced protein over time. The alternative dairy and meat industry is developing at a yearly rate of 15.8% and is predicted to reach 1.2 trillion $USD by 2030. This emerging market incorporates new technologies in plant-made protein production, manufacturing of animal proteins by fermentation using microbial bioreactors, and accelerated production of cultivated (also known as cell-based) meat. These new technologies should change the global market drammatically. This article describes the history of the alternative protein industry and its' current status, then offers predictions of future pathways for this rapidly accelerating market. More speculatively, it discusses factors that lead to shifts in consumer behavior that trend toward the adoptation of new technologies.
Cell-Mediated Immunity (CMI) for SARS-CoV-2 Infection Among the General Population of North India: A Cross-Sectional Analysis From a Sub-sample of a Large Sero-Epidemiological Study

Background Cell-mediated immunity (CMI), or specifically T-cell-mediated immunity, is proven to remain largely preserved against the variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), including Omicron. The persistence of cell-mediated immune response in individuals longitudinally followed up for an extended period remains largely unelucidated. To address this, the current study was planned to study whether the effect of cell-mediated immunity persists after an extended period of convalescence or vaccination. Methods Whole blood specimens of 150 selected participants were collected and tested for Anti-SARS-CoV-2 Interferon-gamma (IFN-γ) response. Ex vivo SARS-CoV-2-specific interferon-gamma Enzyme-linked Immunospot (IFN-γ ELISpot) assay was carried out to determine the levels of virus-specific IFN-γ producing cells in individual samples. Findings Out of all the samples tested for anti-SARS-CoV-2 T-cell-mediated IFN-γ response, 78.4% of samples were positive. The median (interquartile range) spots forming units (SFU) per million levels of SARS-CoV-2-specific IFN-γ producing cells of the vaccinated and diagnosed participants was 336 (138-474) while those who were vaccinated but did not have the disease diagnosis was 18 (0-102); the difference between the groups was statistically significant. Since almost all the participants were vaccinated, a similar pattern of significance was observed when the diagnosed and the never-diagnosed participants were compared, irrespective of their vaccination status. Interpretations Cell-mediated immunity against SARS-CoV-2 persisted, irrespective of age and sex of the participant, for more than six months of previous exposure. Participants who had a history of diagnosed COVID-19 infection had better T-cell response compared to those who had never been diagnosed, in spite of being vaccinated.
Dense Sequential Fusion: Point Cloud Enhancement Using Foreground Mask Guidance for Multimodal 3-D Object Detection

Object detection forms the foundation of safe autonomous vehicle (AV) operation. LiDAR and camera are both widely used detection devices, yet they each come with their unique advantages and drawbacks. For instance, LiDAR sensors face challenges such as obstacle occlusion and long-range object detection when applied to 3-D object recognition. On the other hand, cameras are significantly affected by variations in lighting and weather conditions, and they struggle to provide precise depth information. Hence, multisensor fusion is frequently employed to enhance both the accuracy and robustness of object detection. Prominent issues associated with end-to-end fusion include feature misalignment and suboptimal training strategies, while the challenge for the sequential fusion architecture lies in its inability to fully tap into the capabilities of high-density images to enhance point cloud data, especially when dealing with information sparsity at extended ranges. To address these challenges, we present a dense sequential fusion (DSF) framework specifically designed to fuse camera and LiDAR sensor data. The primary goal is to enhance the accuracy and robustness of 3-D object detection, particularly for distant objects. First, we developed a model for augmenting foreground points, specifically targeting sparse points associated with far-range objects. Second, a foreground points refinement technique was implemented to filter long-tail points generated by images. This refinement process has the capability to improve the object’s distinctiveness, especially when dealing with an abundance of edge points while also supplying high-resolution raw and pseudo foreground points. Finally, voxel-based LiDAR 3-D detection methods were employed to detect 3-D objects utilizing the high-resolution raw and pseudo point clouds. The experimental studies were conducted using the KITTI dataset. The results showed that the proposed method improved 3-D mAP by 2.59% compared with PointPillars and 1.27% average precision (AP) for car hard-level detection compared with SECOND. Furthermore, it improved the bird’s eye view (BEV) AP for far-range car detection by more than 10%.
Neoadjuvant tislelizumab combined with chemotherapy in locally advanced oral or oropharyngeal squamous cell carcinoma: a real−world retrospective study

Objectives The treatment of locally advanced oral or oropharyngeal squamous cell carcinoma (LAOOPSCC) is surgery and radiotherapy or chemoradiotherapy but with unsatisfactory survival rate. Neoadjuvant programmed death-1 (PD-1) therapy are being used in several clinical trials. Therefore, in this retrospective study we aimed to determine the feasibility of neoadjuvant tislelizumab plus chemotherapy followed by surgery for LAOOPSCC. Materials and methods The clinical data of 33 patients with LAOOPSCC who received neoadjuvant PD-1 inhibitors and chemotherapy between April 2021 and October 2022 were retrospectively analyzed. Patients with stage III-IV LAOOPSCC received tislelizumab, albumin-bound paclitaxel, and cisplatin every 3 weeks (Q3W) for two cycles, followed by surgery and adjuvant radiotherapy or concurrent chemoradiotherapy. A median follow-up period was 20 months. Results The objective response rate (ORR) was 66.7%, with the major pathological response (MPR) rate at 54.5%, and the pathological complete response (pCR) rate was 33.3%. Sixteen patients underwent limited surgeries, and 15 patients were remitted from undergoing mandibulectomy and 9 patients were remitted from undergoing near total glossectomy or total glossectomy. A significant difference in the overall survival (OS) and disease-free survival (DFS) was observed in patients who achieved major pathological response (MPR) than who did not. The most common adverse events in neoadjuvant therapy were alopecia, decreased appetite or anorexia, leukopenia, and fatigue. Conclusion Neoadjuvant PD-1 inhibitors combined with chemotherapy are feasible and safe, with a high pathological response and possible organ preservation in oral or oropharyngeal squamous cell carcinoma. However, further studies with a larger cohort of patients and longer follow-up period is required to strengthen our findings and evaluate the survival benefits of the treatment.
The Factors of Job Satisfaction Among Nurses

Introduction: Hospital as health service center must really pay attention to the importance of health services to patients that rely on human resources. Job satisfaction among nurses is one of the factors that contribute to maintaining the quality of health services. As health workers who are directly involved in providing care to patients, nurses have a very strategic role in meeting patient needs and creating a safe, comfortable, and effective care environment. Methods: Research uses an analytical survey design with a cross sectional approach. The population was all 559 nurses. The number of samples was 233, using the proportional sampling method. Data collection using questionnaires, has been tested for validity and reliability test with r value above 0.361. Analysis techniques using chi-square and binary logistic regression analysis. Results: Perception of the nursing manager leadership variable shows an average value of 2.31, which means that the nursing manager leadership is good category. Based on the Chi-Square results, it is known that nursing manager leadership, social support, work family conflict, have a significant relationship with nurse job satisfaction with a p value ≤0.05. Meanwhile, the gender variable does not have a significant relationship with nurses job satisfaction with p value> 0.05 Multivariate analysis with ordinal regression test shows that social support with a p value = 0.00 <0.25 and Wald (OR) value of 15.856 is the largest. Conclution: There is a significant relationship between leadership and job satisfaction of nurses and there is also a significant relationship between social support and job satisfaction of nurses. Keywords: Job Satisfaction, Manager, Leadership, Social Support, Nurses
RADIATION HAZARD INDICES AND EXCESS LIFETIME CANCER RISK IN SOIL, SEDIMENT AND WATER AROUND MINI-OKORO/OGINIGBA CREEK, PORT HARCOURT, RIVERS STATE, NIGERIA.

40 K. The ratio of Th/U for water, sediment and soil samples ranged from 0 to 7.63, 0.54 to 4.72 and 0.17 to 3.64 respectively. Whereas, the ratio K/U and K/Th ranged from 0 to 0.33, 0 to 1.66 and 0.01 to 0.87 and 0.04 to 0.16, 0 to 0.35 and 0.01 to 0.77 for water, sediment and soil respectively. To assess the radiological hazard of river sediments, water and soil ,the radiological hazard indices such as absorbed dose rate, annual effective dose equivalent (AEDE), hazard indices (Hin and Hex),activity utilization index (I), annual gonads dose and excess lifetime cancer risk (ELCR) were calculated and found to be below the internationally recommended values. The contribution of 238 U, 232 Th and 40 K to the effective dose were 56.9%, 27.2% and 15.9% respectively in water, 33.6%, 21.2% and 45.2% respectively in sediment and 71.8%, 14.2% and 14.0% respectively in soil. The results indicate that the radiation hazard from primordial radionuclide in all river water, river sediments and river bank surface soil samples from the area studied is not significant. Therefore there is no immediate radiation health hazard associated with the use of any of the samples studied.
Knowledge about Snake Venoms and Toxins from Colombia: A Systematic Review

Colombia encompasses three mountain ranges that divide the country into five natural regions: Andes, Pacific, Caribbean, Amazon, and Orinoquia. These regions offer an impressive range of climates, altitudes, and landscapes, which lead to a high snake biodiversity. Of the almost 300 snake species reported in Colombia, nearly 50 are categorized as venomous. This high diversity of species contrasts with the small number of studies to characterize their venom compositions and natural history in the different ecoregions. This work reviews the available information about the venom composition, isolated toxins, and potential applications of snake species found in Colombia. Data compilation was conducted according to the PRISMA guidelines, and the systematic literature search was carried out in Pubmed/MEDLINE. Venom proteomes from nine Viperidae and three Elapidae species have been described using quantitative analytical strategies. In addition, venoms of three Colubridae species have been studied. Bioactivities reported for some of the venoms or isolated components—such as antibacterial, cytotoxicity on tumoral cell lines, and antiplasmodial properties—may be of interest to develop potential applications. Overall, this review indicates that, despite recent progress in the characterization of venoms from several Colombian snakes, it is necessary to perform further studies on the many species whose venoms remain essentially unexplored, especially those of the poorly known genus Micrurus.
Depletion of Labile Iron Induces Replication Stress and Enhances Responses to Chemoradiation in Non-Small-Cell Lung Cancer

The intracellular redox-active labile iron pool (LIP) is weakly chelated and available for integration into the iron metalloproteins that are involved in diverse cellular processes, including cancer cell-specific metabolic oxidative stress. Abnormal iron metabolism and elevated LIP levels are linked to the poor survival of lung cancer patients, yet the underlying mechanisms remain unclear. Depletion of the LIP in non-small-cell lung cancer cell lines using the doxycycline-inducible overexpression of the ferritin heavy chain (Ft-H) (H1299 and H292), or treatment with deferoxamine (DFO) (H1299 and A549), inhibited cell growth and decreased clonogenic survival. The Ft-H overexpression-induced inhibition of H1299 and H292 cell growth was also accompanied by a significant delay in transit through the S-phase. In addition, both Ft-H overexpression and DFO in H1299 resulted in increased single- and double-strand DNA breaks, supporting the involvement of replication stress in the response to LIP depletion. The Ft-H and DFO treatment also sensitized H1299 to VE-821, an inhibitor of ataxia telangiectasis and Rad2-related (ATR) kinase, highlighting the potential of LIP depletion, combined with DNA damage response modifiers, to alter lung cancer cell responses. In contrast, only DFO treatment effectively reduced the LIP, clonogenic survival, cell growth, and sensitivity to VE-821 in A549 non-small-cell lung cancer cells. Importantly, the Ft-H and DFO sensitized both H1299 and A549 to chemoradiation in vitro, and Ft-H overexpression increased the efficacy of chemoradiation in vivo in H1299. These results support the hypothesis that the depletion of the LIP can induce genomic instability, cell death, and potentiate therapeutic responses to chemoradiation in NSCLC.
A Real-World Data Driven Pharmacovigilance Investigation on Drug-Induced Arrhythmia Using KAERS DB, a Korean Nationwide Adverse Drug Reporting System

This study aims to investigate the prevalence and seriousness of drug-induced arrhythmia and to identify predictors associated with the seriousness of arrhythmia. Drug-induced arrhythmia cases reported to the Korean Adverse Event Reporting System Database (KAERS DB) from January 2012 to December 2021 were investigated. A disproportionality test was performed to detect the association of the etiologic medication classes and types, along with patient demographic information, with the seriousness of drug-induced arrhythmia. Logistic regression was performed to investigate the predictors that increase the risk of serious arrhythmia. The most common etiologic agent for drug-induced arrhythmia was sevoflurane, whereas serious arrhythmia was most prevalent with narcotics. Antibiotics (reporting odds ratio (ROR) 4.125; 95% CI 1.438–11.835), chemotherapy (ROR 6.994; 95% CI 2.239–21.542), and iodinated contrast media (ROR 8.273; 95% CI 3.062–22.352) had a strong association with the seriousness of drug-induced arrhythmia. Among numerous etiologic agents, ioversol (ROR 16.490; 95% CI 3.589–75.772) and lidocaine (ROR 12.347; 95% CI 2.996–50.884) were more likely to be reported with serious arrhythmia. Aging and comorbidity, primarily cancer, are the most contributing predictors associated with serious arrhythmia. Further studies on the clinical significance of patient-specific predictors for the increased risk of serious drug-induced arrhythmia are warranted to promote drug safety.
Fluid inclusion study in the Huanuni mine, Bolivia.

A study on fluid inclusions in quartz and cassiterite from the Huanuni mine in the western part of Bolivia was carried out.Secondary inclusions along a healed crak show a wide range of filling temperatures but a narrow range of salinities. This would suggest that inclusions were trapped from similar solution in different gas/liquid ratios, due mainly to boiling of the ore forming fluid.The mode of occurrence of the fluid inclusions indicate that the fluid boiled frequentely at all stages of mineral deposition. Since the lowest filling temperature of those inclusions would be close to the trapping temperature, we conclude that the forming temperatures in the early and late vein stages were about 350°and 100°, respectively.The boiling under conditions of super saturation, also would cause the profuse deposition of fine grain minerals at Huanuni mine.
Vegetation and land carbon projections for Wisconsin, USA, in the 21st century

In this sudy, a dynamic vegetation model is forced by statistically downscaled climate projections across Wisconsin for the 21st century, produced by the Wisconsin Initiative on Climate Change Impacts using climate output from the Fourth Assessment Report of the Intergovern mental Panel on Climate Change. The mean climate projection is substantial warming and an increase in cool-season precipitation. Drying soil leads to reduced tree cover across southern and western Wisconsin, establishing a more prairie-like environment. Along with a statewide reduction in evergreen tree cover and increase in deciduous tree cover, the tension zone shifts northward, potentially out of the state by the end of the century. Projected climate change produces a dramatic loss of terrestrial carbon, primarily from vegetation during the first half of the century and from both vegetation and soil in the second half. Carbon fertilization should partly offset this loss of carbon to the atmosphere. Projected transfers of carbon from terrestrial vegetation to the atmosphere are larger for higher-end climate-change scenarios. The land carbon projections for Wisconsin in this study have critical implications to the state’s future plans to reduce atmospheric greenhouse gas concentrations through focused efforts to cut emissions.
First-Time Parents’ Bonding with Their Baby: A Longitudinal Study on Finnish Parents during the First Eight Months of Parenthood

Early positive bonding between parents and babies promotes the development of parenting skills and parents’ sensitivity to their infant’s needs. Positive bonding has been suggested to decrease the risk of maltreatment. There is less research into the differences between primiparae’s and their spouses’ bonding with their baby and changes in the parent-to-infant bonding during the first year of the baby’s life. The aim of this study was to describe bonding with one’s baby and related differences and changes within first-time parents. The data were collected from nine maternal health clinics in 2019–2021 in one city in Finland. The Mother-to-Infant Bonding Scale (MIBS) and the Edinburgh Postnatal Depression Scale (EPDS) were used. The data were collected during pregnancy (T1) and when the baby was aged 1–2 months (T2) and 6–8 months (T3). The questionnaire was completed separately by the primiparae (n = 81 at T1) and their spouses (n = 79 at T1). The findings demonstrated that both parents had positive feelings for their baby. The primiparae’s and their spouses’ MIBS scores were relatively low at T2 and T3. The change between time points or the difference in the parents’ bonding was not statistically significant when examining MIBS total scores. The present study identified a positive weak-to-moderate correlation between the MIBS and EPDS. This association was highlighted in the group of primiparae. The results of this study can be used to develop maternity and child health clinic services, and to promote parents’ equal growth in parenthood.
Discussion on the Deep Dynamic Mechanism of Gold Mineralization Concentration Area in northwestern Jiaodong

Nearly 25% of gold reserves in China distributes in northwestern Jiaodong,which has an area less than 0.25% of the national land area.Northwestern Jiaodong not only has the greatest gold reserves in China,a concentratived metallogenic time at 115±5Ma,but is characterized by gold-bearing veins,vertical extensions of which are larger than those of horizontal extension.Therefore,they have drawn much attention from geologists both in China and abroad.Our study indicates that Au ore intensive district in northwestern Jiaodong is related to deep ore-controlling structures.After experiencing evolution of long stable platform during Paleozoic,the eastern area of North China Platform entered the stage of mantle plume evolution in Yanshanian movement period.The Jiaodong was located exactly in the center of the mantle plume.Meanwhile,northwestern Jiaodong developed a series of mantle branches such as Guojiadian,Qishan and Panshidian around the Laiyang-Laixi sub-mantle plume.Through mantle plume→sub-mantle plume→mantle branch→favorable structural expanding zones,deep derived gaseous or gas-liquid Au-bearing hydrothermal fluid migrated to the ductile-brattle or brattle-ductile zones,internal or external contact zones of intrusives,dense structural fractures,contact zones between dykes and country rocks,forming a series of gold deposits.This produced an external ore intensive zone containing Jiudian-Xiadian-Dayinggezhuang-Qixia-Rushan deposits surrounding the Laiyang-laixi mantle plume,and an internal ore intensive zone consisting of Jigezhuang-Sanshandao-Jiaojia-Linglong-Daliuhang-Xiejiazhuang-Quhezhuang deposits.Both ore intensive zones consitiute a series of orefield-ore deposits-ore veins assemblages.
Best sum-throughput evaluation of cooperative downlink transmission nonorthogonal multiple access system

In cooperative simultaneous wireless information and power transfer (SWIPT) nonorthogonal multiple access (NOMA) downlink situations, the current research investigates the total throughput of users in center and edge of cell. We focus on creating ways to solve these problems because the fair transmission rate of users located in cell edge and outage performance are significant hurdles at NOMA schemes. To enhance the functionality of cell-edge users, we examine a two-user NOMA scheme whereby the cell-center user functions as a SWIPT relay using power splitting (PS) with a multiple-input single-output. We calculated the probability of an outage for both center and edge cell users, using closed-form approximation formulas and evaluate the system efficacy. The usability of cell edge users is maximized by downlink transmission NOMA (CDT-NOMA) employing a SWIPT relay that employs PS. The suggested approach calculates the ideal value of the PS coefficient to optimize the sum throughput. Compared to the noncooperative and single-input single-output NOMA systems, the best SWIPT-NOMA system provides the cell-edge user with a significant throughput gain. Applying SWIPT-based relaying transmission has no impact on the framework’s overall throughput.