Miracle-dz/UniFAR-FTUs huggingface dataset:
Relationship Between Vaccination Status and Biopsychosocial Characteristics in Sheltered Adolescents

Introduction Homeless youth are a vulnerable population. A volunteer clinic supported by medical students in northeastern Pennsylvania provides shelter and healthcare to adolescents seeking refuge. We set out to determine the immunization status of youth in the shelter and evaluate for associations of immunization deficiency with demographics or biopsychosocial factors. Methods After IRB approval, a retrospective cohort study was performed from existing clinical records at the shelter 2/2015-9/2019. Chart abstraction included variables such as demographics (including age, sex, and race/ethnicity), biopsychosocial factors (including childhood trauma/abuse history, substance abuse history, and sexual activity), and immunization history. Results A total of 440 charts were analyzed. When comparing demographics of patients that had complete vaccine regimens versus those who did not, the race was statistically significant (p=.006). The most prominent difference in race was seen for Black/African American patients; only 19.57% had a completed vaccine regimen documented. Regarding immunization history, vaccine schedules of hepatitis B, measles mumps rubella (MMR), inactivated polio vaccine (IPV), and varicella were most likely to be complete; pneumococcal conjugate vaccine (PCV) 13, rotavirus, influenza, and human papillomavirus vaccine (HPV) were least likely. There was no association found between a completed vaccine regimen and biopsychosocial variables. A larger portion of females (37.35%) completed the HPV vaccine compared to males (23.14%) (p=.009). Conclusions In this single-site study, this vulnerable, at-risk population of sheltered adolescents lacked the vaccinations recommended by the Centers for Disease Control and Prevention. Racial disparities further compounded this vulnerability for Black/African American teens. Additionally, a significantly greater number of female patients received the HPV vaccine compared to males.
7T Magnetization Transfer and Chemical Exchange Saturation Transfer MRI of Cortical Gray Matter: Can We Detect Neurochemical and Macromolecular Abnormalities?

Abstract : We present the first annual report for this project. We have developed and deployed a quantitative MRI set of MRI scans at 7T in healthy volunteers and have developed an analysis pipeline for the quantification of macromolecular and metabolic indices reflective of demyelination and neurotransmitter/protein accumulation. All quantitative MRI methods deployed in humans were optimized and vetted via phantom work and simulation. We are happy to report initial findings that show excellent image quality and differences between the normal cohort and one MS patient. Additionally, we have developed, in conjunction with Dr. Newhouse, a neurocognition expert, an extensive neuropsychiatric battery for correlation studies in year 2. We have had excellent recruitment and retention and look forward to group comparisons in year 2.
Heterotopic pancreas: the added value of endoscopic ultrasound with Computed Tomography for diagnosis.

AIMS To investigate the added value of endoscopic ultrasound (EUS) with computed tomography (CT) in distinguishing heterotopic pancreas (HP) from other pathologies, when gastroduodenal subepithelial tumors (SETs) are suspected on an upper endoscopic examination. MATERIAL AND METHODS We retrospectively included 54 consecutive patients with gastroduodenal SETs who had undergone both abdominal CT and EUS within a 3-month interval. All EUS, endoscopy, and CT images were reviewed and evaluated in a blinded manner by an endoscopist and a radiologist, respectively. Univariate and multivariate analyses were performed to identify EUS/CT findings related to HP. Diagnostic performance of CT only and CT combined with EUS was compared for distinguishing HP from other SETs. RESULTS We included patients with HP (n=17; pathologically confirmed, n=6), gastrointestinal stromal tumor (GIST, n=24), and other pathologies (n=13). Multivariate logistic regression analyses revealed that irregular margin, origin from submucosal layer, internal microcystic-tubular structure, and oval shape were independent factors in diagnosing HP by EUS, whereas a micro-lobulating contour was the only significantly independent factor in CT. In assessments of diagnostic performance, CT combined with EUS showed significantly superior diagnostic performance in comparison with CT only (area under the curve, 0.961 vs. 0.833, p=0.028) in the consensus interpretation of an endoscopist and a radiologist. CONCLUSIONS CT combined with EUS with a comprehensive and complementary interpretation showed significant added value compared to CT only in diagnosing gastroduodenal HP.
Comprehensive Health Assessment 3 Months After Recovery From Acute Coronavirus Disease 2019 (COVID-19)

Abstract Background Long-term health sequelae of coronavirus disease 2019 (COVID-19) may be multiple but have thus far not been systematically studied. Methods All patients discharged after COVID-19 from the Radboud University Medical Center, Nijmegen, the Netherlands, were consecutively invited to a multidisciplinary outpatient facility. Also, nonadmitted patients with mild disease but with symptoms persisting >6 weeks could be referred by general practitioners. Patients underwent a standardized assessment including measurements of lung function, chest computed tomography (CT)/X-ray, 6-minute walking test, body composition, and questionnaires on mental, cognitive, health status, and quality of life (QoL). Results 124 patients (59 ± 14 years, 60% male) were included: 27 with mild, 51 with moderate, 26 with severe, and 20 with critical disease. Lung diffusion capacity was below the lower limit of normal in 42% of discharged patients. 99% of discharged patients had reduced ground-glass opacification on repeat CT imaging, and normal chest X-rays were found in 93% of patients with mild disease. Residual pulmonary parenchymal abnormalities were present in 91% of discharged patients and correlated with reduced lung diffusion capacity. Twenty-two percent had low exercise capacity, 19% low fat-free mass index, and problems in mental and/or cognitive function were found in 36% of patients. Health status was generally poor, particularly in the domains functional impairment (64%), fatigue (69%), and QoL (72%). Conclusions This comprehensive health assessment revealed severe problems in several health domains in a substantial number of ex–COVID-19 patients. Longer follow-up studies are warranted to elucidate natural trajectories and to find predictors of complicated long-term trajectories of recovery.
Diurnal variation in excitation-contraction coupling in rat ventricular myocytes

Rodrigo, G.C. , Collins, H.E. The role o f nitric oxide in the diumal variation in excitation-contraction coupling in ventricular myocytes. The Annual Physiological Society meeting, Dublin, July 2009. Poster presentation. Collins, H.E. , Rodrigo, G.C. Diumal variation in excitation-contraction coupling in rat ventricular myocytes: sensitivity to P-adrenergic stimulation. The Annual Physiological Society meeting, Dublin, July 2009. Oral presentation. Collins, H.E. , Rodrigo, G.C. Diumal variation in the response o f cardiac ventricular myocytes to p-adrenergic stimulation: Involvement o f endogenous nitric oxide. European society o f Cardiology congress meeting, Barcelona, August 2009. Poster presentation.
Epidemiology and risk factors for varicella zoster virus reactivation in heart transplant recipients

Heart transplant (HT) recipients are at higher risk of varicella zoster virus (VZV) reactivation. Risk factors for VZV reactivation are currently not well defined, impeding the ability to design and implement strategies to minimize the burden of this illness in this population. Automated data extraction tools were used to retrieve data from the electronic health record (EHR) of all adult HT recipients at our center between 2010 and 2016. Information from the Organ Procurement and Transplantation Network Standard Analysis and Research Files was merged with the extracted data. Potential cases were manually reviewed and adjudicated using consensus definitions. Cumulative incidence and risk factors for VZV reactivation in HT recipients were assessed by the Kaplan‐Meier method and Cox modeling, respectively. In 203 HT recipients, the cumulative incidence of VZV reactivation at 8‐years post‐transplantation was 26.4% (95% CI: 17.8‐38.0). The median time to VZV reactivation was 2.1 years (IQR, 1.5‐4.1). Half (14/28) of the cases experienced post‐herpetic neuralgia (PHN). Post‐transplant CMV infection (HR 9.05 [95% CI: 3.76‐21.77) and post‐transplant pulse‐dose steroids (HR 3.19 [95% CI: 1.05‐9.68]) were independently associated with a higher risk of VZV reactivation in multivariable modeling. Identification of risk factors will aid in the development of targeted preventive strategies.
Toxicity Analysis of Polycyclic Aromatic Hydrocarbon Mixtures

Toxicity Analysis of Polycyclic Aromatic Hydrocarbon Mixtures. (May 2009) Christine Sue Naspinski, B.S., Pennsylvania State University Co-Chairs of Advisory Committee: Dr. Kirby C. Donnelly Dr. Thomas J. McDonald Polycyclic aromatic hydrocarbons (PAHs) are widely distributed in the environment and are generated by many sources. Though the potential of PAH-rich mixtures to cause health effects has been known for almost a century, there are still unanswered questions about the levels of PAHs in the environment, the potential for human exposure to PAHs, the health effects associated with exposure, and how genetic susceptibility influences the extent of health effects in individuals. The first objective of this research was to quantify concentrations of PAHs in samples of settled house dust collected from homes in Azerbaijan, China, and Texas. The trends of PAH surface loadings and percentage of carcinogenic PAHs were China > Azerbaijan > Texas, indicating that the risk of health effects from exposure to PAHs in house dust is highest in the Chinese population and lowest in the Texas population. PAHs in China and Azerbaijan were derived mainly from combustion sources; Texas PAHs were derived from unburned fossil fuels such as petroleum. The second objective of this research was to investigate the effect of pregnane X receptor (PXR) on the genotoxicity of benzo[a]pyrene (BaP). BaP treatment resulted in significantly lower DNA adduct levels in PXR-transfected HepG2 cells than in parental HepG2 cells. Total GST enzymatic activity and mRNA levels of several metabolizing enyzmes were significantly higher in cells overexpressing PXR. These results suggest that PXR protects cells against DNA damage by PAHs such as BaP, possibly through a coordinated regulation of genes involved in xenobiotic metabolism. The third objective of this research was to investigate biomarkers of exposure in house mice (Mus musculus) exposed to PAH mixtures in situ. Mice and soil were collected near homes in Sumgayit and Khizi, Azerbaijan. Mean liver adduct levels were significantly higher in Khizi than in Sumgayit. Mean lung and kidney adduct levels were
Impact of the COVID‐19 pandemic on inpatient dermatology: a multicentre study from Hubei, China

Dermatology practices worldwide are resuming routine clinical activities in the post-pandemic era. Understanding the impact of the COVID-19 pandemic on inpatient dermatology practices will empower physicians to better prepare for the challenges ahead. We aimed to investigate changes in the composition of dermatology wards with respect to inpatient diagnoses and disease characteristics, once the lockdown was lifted in Hubei, the first and worst affected area of COVID-19 in China.
Hands-on training based on quantifying radiant exposure improves how dental students cure composites: Skill retention at 2-year follow up.

INTRODUCTION The durability and longevity of composite restoration are much dependent on the accurate delivery of the energy required to polymerize the material. This study aimed to investigate the extent to which undergraduate dental students acquire and retain light-curing skills following hands-on training. MATERIALS AND METHODS Hands-on training comprises faculty tutoring for critical aspects of the light-curing procedure, such as distance and angulation of the light-curing tip. Assessments of the students' ability to deliver a specified radiant exposure to class III and I simulated RBCs using a dental simulator (MARC-PS®) at three different time points after the training. Data were analyzed using repeated measure ANOVA. RESULTS Immediately after the training, students' performance on curing were improved (p<0.05). Overall, the radiant exposure increased after training, but the students lost some of the benefits with time. For curing in the anterior section (anterior sensor -class III), the mean radiant exposure values increased by approximately 20% after the training. After two years, the values were 15% greater than baseline values. For curing in the posterior section ( posterior sensor -class I), the mean radiant exposure values increased by approximately 150% after the training. A significant decrease (p<0.05) was observed; however, the radiant exposure values were still 82% greater than the baseline after two years. CONCLUSION A hands-on training dedicated to light-curing procedures facilitated acquisition and retention up to a 2-year follow up of skill on how light cure composite inside the mouth. The training was more relevant for curing in posterior areas, where orientation can significantly impact light-curing. A hands-on training where the radiant exposure can be measure gave objective measurement metrics to guide the curing performance. This approach is an effective means of teaching practical skills to dental students.
Global transcriptome analysis of Rhizobium favelukesii LPU83 in response to acid stress.

Acidic environments naturally occur worldwide and inappropriate agricultural management may also cause acidification of soils. Low soil pH values are an important barrier in the plant-rhizobia interaction. Acidic conditions disturb the establishment of the efficient rhizobia usually used as biofertilizer. This negative effect on the rhizobia-legume symbiosis is mainly due to the low acid-tolerance of the bacteria. Here, we describe the identification of relevant factors in the acid tolerance of Rhizobium favelukesii using transcriptome sequencing. A total of 1,924 genes were differentially expressed under acidic conditions, with ca. 60% underexpressed. R. favelukesii acid response mainly includes changes in the energy metabolism and protein turnover, as well as a combination of mechanisms that may contribute to this phenotype, including GABA and histidine metabolism, cell envelope modifications and reverse proton efflux. We confirmed the acid-sensitive phenotype of a mutant in the braD gene, which showed higher expression under acid stress. Remarkably, 60% of the CDS encoded in the symbiotic plasmid were underexpressed and we evidenced that a strain cured for this plasmid featured an improved performance under acidic conditions. Hence, this work provides relevant information in the characterization of genes associated with tolerance or adaptation to acidic stress of R. favelukesii.
Minéralisation in situ de la matière organique le long de la colonne d'eau : application sur une station eulérienne.

The carbon cycle is mostly driven by production and remineralisation processes which are constraining organic matter concentration along the water column. The main actors of the remineralisation are the heterotrophic prokaryotes, which actions can be measured from surface to deep by the prokaryotic respiration. During this PhD thesis, a long term real time monitoring of hydrological and biogeochemical conditions (potential temperature, salinity and dissolved oxygen O2) has been carried out between 2008 and 2010 in the North Occidental Mediterranean Sea, at the ANTARES site. Influence of punctual events has been observed which seem to be related to winter deep sea convection and subsequent advection, changing hydrological and biogeochemical properties observed at the ANTARES site. These direct or indirect modifications will have consequences on the organic matter concentration and therefore on the deep-sea remineralisation potential. The temporal monitoring of O2 concentration has also allow us to estimate the deep water oxygen consumption of 2.6 µmol O2 dm-3 a-1, during a three year period. The development in our laboratory in collaboration with Centre de Physique des Particules de Marseille (CPPM) of a new equipressured tool, the IODA6000 (In situ Oxygen Dynamics Autosampler), measuring directly and at high frequency the O2 concentration, allowed us to measure PR rates at 2000 m depth since December 2009 at the ANTARES site. This unique ongoing time series shows a mean prokaryotic respiration rates higher (0.2 µmol O2 dm-3 d-1) than expected by literature (5.5 10-3 µmol O2 dm-3 d-1), with a high temporal variability (from 8 10-3 to 0.5 µmol O2 dm-3 d-1).
Myelitis in inflammatory disorders associated with myelin oligodendrocyte glycoprotein antibody and aquaporin‐4 antibody: A comparative study in Chinese Han patients

Myelitis is an important clinical component of myelin oligodendrocyte glycoprotein antibody (MOG‐ab)‐associated disease (MOGAD) and aquaporin‐4 antibody (AQP4‐ab)‐positive neuromyelitis optica spectrum disorder (NMOSD). The aim of this work was to evaluate the differentiating features of myelitis between the two diseases.
Calmodulin level is significantly increased in the cerebrospinal fluid of patients with sporadic Creutzfeldt‐Jakob disease

Human prion diseases (PrDs) are a group of fatal and transmissible neurodegenerative disorders that are diagnosed definitively in post mortem brains. Calmodulin (CaM) is a ubiquitous calcium‐binding protein. Increased brain CaM level has been reported in prion‐infected rodent models and some scrapie‐infected cells. However, the putative alteration of CaM in cerebrospinal fluid (CSF) of human PrDs is uncertain. Here, we try to figure out the profiles of CSF CaM in sporadic Creutzfeldt‐Jacob disease.
Short strides to important findings: A short interval longitudinal study of sleep quality, psychological distress and microstructure changes to the uncinate fasciculus in early adolescents

Developmental studies have shown adolescence is a period of ongoing white matter (WM) development, reduced sleep quality and the onset of many mental disorders. Findings indicate the WM development of the uncinate fasciculus (UF), a WM tract suggested to play a key role in mental disorders, continues throughout adolescence. While these studies provide valuable information, they are limited by long intervals between scans (1 to 4 years) leaving researchers and clinicians to infer what may be occurring between time‐points. To allow inferences to be made regarding the impact that sleep quality may be having on WM development, longitudinal studies with much shorter between‐scan intervals are required.
Students’ Perception of Online Learning during COVID-19 Pandemic: A Survey Study of IT Students

: With the sudden change in an environment with the new coronavirus, online learning has become a promising solution for the education sector all over the globe. Despite gaining popularity of online learning with the emergence of the internet, and new technology students are more inclined towards the traditional face to face learning rather than online learning before COVID-19. The present survey aimed to examine the students’ perception of online learning during the COVID-19 pandemic period at the ATI in Dehiwala, Sri Lanka. Out of 130 participants, 62.5% had little or no experience with online learning prior to the coronavirus outbreak, 54.7% preferred blended learning of traditional learning and online learning. The most popular device used to connect online is the smartphone (43.8%). Regardless of the challenges to online learning during the COVID-19 included issues related to reduce interaction between the lecturer and friends (64.1%), social isolation (55.5%), and technical problems (57%). Irrespective of these challenges, students perceive online learning as effective as face to face learning, enjoyable, able to learn at own pace, easy access to online material, and active participation. 82.9% of students agreed to integrate online learning into their course in the future and overall perception regarding online learning during COVID-19 is 79.7%. In conclusion, the current survey displays a favorable perception of online learning among IT students.
Nanostructured Materials in Electrochemistry

Electrochemically Synthesized Nanowire-Based Electrodes: Morphology and Transport Studies Electrochemical Characterization of Nanoparticles: Assembly and Their Charge Transfer at Interfaces Template-assisted Electrochemical Growth of Nanowires and Nanotubes Nanopores Formed by Anodization of Aluminium and Nanowire Arrays Grown in Porous Alumina Templates Functional Low-Scale Electrodes in Electrochemical Systems Top-Down Approaches to the Fabrication of Nanopatterned Electrodes Self-Organized Formation of Layered Nanostructures by Oscillatory Electrodeposition Electrochemical Corrosion Behaviour of Nanocrystalline Materials Nanostructured Active/Inactive Anodes for Rechargeable Li-ion Batteries Nanomaterials for Hydrogen Storage Synthesized by Mechanical Alloying Nanosized Titanate Oxides and Their Application in Energy Storage and Energy Conversion Selected Nanostructured Materials in Preparation of DNA Biosensors Noble Metal Nanomaterials: Applications in Electroanalysis Nanostructured Silica-derived Materials: Preparation, Characterization and Electrochemical Properties
Psychological outcomes after hospitalization for COVID-19: data from a multidisciplinary follow-up screening program for recovered patients

Patients who are hospitalized for coronavirus disease 2019 (COVID-19) face an extremely stressful experience that might challenge their mental health. The study aims to describe the psychological condition of recovered patients, focusing on anxiety and depression symptoms, as well as post-traumatic stress. All the recovered COVID-19 patients who accessed to a multidisciplinary follow-up screening program scheduled within two months after their hospital discharge were included. As far as the psychological assessment, patients completed the Hospital Anxiety and Depression Scale and the Impact of Event Scale- Revised for post-traumatic stress. Socio-demographic and clinical data (days of hospitalization, intensity of received care, and number of supportive sessions with the hospital psychologist after the hospitalization) were collected. Descriptive, correlation and regression analyses were conducted. The sample includes 261 patients (68.2% men), aged between 23 and 90 (mean=58.9 st. dev=13.3). High numbers of patients reported anxiety (28%) and depression symptoms (17%), as well as post-traumatic stress (36.4%). Impaired outcomes were associated with female gender, while patient’s age was found to be negatively correlated with anxiety symptoms. 13.8% of patients underwent a psychological visit and 6.1% of them were taken in charge for psychological support. Few months after hospital discharge, individuals recovered by COVID-19 reported negative consequences on their mental health. Understanding the impact that COVID-19 and hospitalization have on recovered patients may provide insights about how to develop an effective psychological intervention to help them deal with such psychological distress and prevent further psychopathological effects.