Miracle-dz/UniFAR-FTUs huggingface dataset:
Towards a Taxonomy of Trustworthy Digital Repository Impacts

Measuring the societal impact of digital repositories is a wicked problem. To capture information about the impacts of digital repositories that become certified as Trustworthy Digital Repositories (TDRs), a taxonomy describing activities cited as evidence of compliance with TDR standards is needed to relate those activities to socially beneficial outcomes. This paper presents a Minimum Viable Prototype (MVP) for a TDR Impacts taxonomy to enable the expression of their activities in a structured way. Our MVP provides a proof‐of‐concept that by formalizing concepts about TDRs in a taxonomy, we can investigate ways to measure whether the impacts associated with becoming and remaining a certified TDR are also impacts that generate societal value. Implications of the work described include potential strategies to identify, extract, and/or author machine‐readable descriptions of measurable facets of TDR activities and the resulting impacts on communities.
A Conceptual Framework of Data (Info) Quality Revisited

This study reports a critical assessment of whether the framework of data (information) quality identified by Wang and Strong's (1996) seminal article continues to hold true in a diverse 21st century information environment. Our study attempts to identify the salient changes that have taken place since Wang and Strong's analysis by exploring wiki contributors' perceived information quality on Wikipedia. An online qualitative survey was conducted with 197 respondents who are Wikipedia readers and/or contributors. Our preliminary results from the unidimensional data analysis reveal over 20 information quality dimensions including a new category, with multiple dimensions.
Is Interdisciplinary Collaboration Research More Disruptive Than Monodisciplinary Research?

As an important pattern of scientific research, interdisciplinary collaboration is universally encouraged by science and technology policy makers. However, it remains a question whether interdisciplinary collaboration research is more disruptive than monodisciplinary research. To address this research question in this study, interdisciplinary collaboration is measured as whether the authors of a paper are from at least two disciplines, and the degree of “disruptive” is measured by the Disruption index proposed by Funk & Owen‐Smith (2017). By using articles published in six journals from 1978 to 2019 in the Microsoft Academic Graph (MAG) database, we constructed an OLS regression model with journal fixed effect and time fixed effect to analyze the influence of interdisciplinary collaboration on the Disruption values with different citation windows. The findings show that interdisciplinary collaboration research is less disruptive than monodisciplinary research.
Dynamin-2 Phosphorylation as A Critical Regulatory Target of Bin1 and GSK3α for Endocytosis in Muscle

Tight regulation of endocytosis ensures accurate control of cellular signaling and membrane dynamics, which are crucial for tissue morphogenesis and functions. Mutations of Bin1 and dynamin-2 (Dyn2), proteins that generate membrane curvature and sever endocytic invaginations, respectively, cause progressive hereditary myopathy. Here, we show that Bin1 inhibits Dyn2 via direct interaction of its SRC Homology 3 (SH3) domain with the proline-rich domain (PRD) of Dyn2. Phosphorylation of S848 of Dyn2 by GSK3α, a kinase downstream of insulin signaling, relieves Dyn2 from the inhibition of Bin1 and promotes endocytosis in muscle. Mutations of Bin1 associated with centronuclear myopathy disrupt its inhibition of Dyn2, thereby exaggerating Dyn2 fission activity and causing excessive fragmentation of T-tubules in the muscle cells. Our work reveals how Bin1-Dyn2 interaction fine-tunes membrane remodeling at the molecular level, and lay the foundation for future exploration of endocytic regulation and hereditary muscle diseases.
Candida albicans commensalism in the oral mucosa is favoured by limited virulence and metabolic adaptation

As part of the human microbiota, the fungus Candida albicans colonizes the oral cavity and other mucosal surfaces of the human body. Commensalism is tightly controlled by complex interactions of the fungus and the host to preclude fungal elimination but also fungal overgrowth and invasion, which can result in disease. As such, defects in antifungal T cell immunity render individuals susceptible to oral thrush due to interrupted immunosurveillance of the oral mucosa. The factors that promote commensalism and ensure persistence of C. albicans in a fully immunocompetent host remain less clear. Using an experimental model of C. albicans oral colonization in mice we explored fungal determinants of commensalism in the oral cavity. Transcript profiling of the oral isolate 101 in the murine tongue tissue revealed a characteristic metabolic profile tailored to the nutrient poor conditions in the stratum corneum of the epithelium where the fungus resides. Metabolic adaptation of isolate 101 was also reflected in enhanced nutrient acquisition when grown on oral mucosa substrates. Persistent colonization of the oral mucosa by C. albicans also correlated inversely with the capacity of the fungus to induce epithelial cell damage and to elicit an inflammatory response. Here we show that these immune evasive properties of isolate 101 are explained by a strong attenuation of a number of virulence genes, including those linked to filamentation. De-repression of the hyphal program by deletion or conditional repression of NRG1 abolished the commensal behaviour of isolate 101, thereby establishing a central role of this factor in the commensal lifestyle of C. albicans in the oral niche of the host. AUTHOR SUMMARY The oral microbiota represents an important part of the human microbiota and includes several hundreds to several thousands of bacterial and fungal species. One of the most prominent fungus colonizing the oral cavity is the yeast Candida albicans. While the presence of C. albicans usually remains unnoticed, the fungus can under certain circumstances cause lesions on the lining of the mouth referred to as oral thrush or contribute to other common oral diseases such as caries. Maintaining C. albicans commensalism in the oral mucosa is therefore of utmost importance for oral health and overall wellbeing. While overt fungal growth and disease is limited by immunosurveillance mechanisms during homeostasis, C. albicans strives to survive and evades elimination from the host. Here, we show that while commensalism in the oral cavity is characterized by a restricted fungal virulence and hyphal program, enforcing filamentation in a commensal isolate is sufficient for driving pathogenicity and fungus-induced inflammation in the oral mucosa thwarting persistent colonization. Our results further support a critical role for specialized nutrient acquisition allowing the fungus to thrive in the nutrient poor environment of the squamous epithelium. Together, this work revealed key determinants of C. albicans commensalism in the oral niche.
Do You Care Who Flagged This Post? Effects of Moderator Visibility on Bystander Behavior

This study evaluates whether increasing information visibility around the identity of a moderator influences bystanders’ likelihood to flag subsequent unmoderated harassing comments. In a 2-day preregistered experiment conducted in a realistic social media simulation, participants encountered ambiguous or unambiguous harassment comments, which were ostensibly flagged by either other users, an automated system (AI), or an unidentified moderation source. The results reveal that visibility of a content moderation source inhibited participants’ flagging of a subsequent unmoderated harassment comment, presumably because their efforts were seen as dispensable, compared to when the moderation source was unknown. On the contrary, there was an indirect effect of other users versus AI as moderation source on subsequent flagging through changes in perceived social norms. Overall, this research shows that the effects of moderation transparency are complex, as increasing visibility of a content moderator may inadvertently inhibit bystander intervention. This study examines the effects of flagging unmoderated offensive posts on social media, and how this changes the users’ subsequent behavior. We examined users’ reactions to the flagging of these posts by other users, an automated system, or an unspecified process to determine whether this affects the users’ ensuing behavior. A 2-day experiment on a simulated social media site showed that the visibility of the “flagger” impacts how users perceive social norms and think about the accountability for their own online actions. The results showed that the visibility of the person/system that flagged the material generally deterred subsequent flagging. The analysis also shows that the effect was stronger when the users thought that it was other users, and not an automated system, that had flagged the online harassment.
Electrophysiological Prints of Grit

While scientific interest in understanding the grit trait has grown exponentially in recent years, one important gap in the grit literature relates to its biological and neural substrate. In the present study, we adopted a hypotheses-driven approach in a large sample of young adults (N = 120) with diverse educational backgrounds and work experiences in order to investigate the electrophysiological correlates of grit both during rest and while performing a learning task. Additionally, we selected a measure of impulsiveness to better understand the neural similarities and differences between grit and related self-control constructs. Based on previous work that implicated the prefrontal cortex in grit, we hypothesized that high grit participants would have lower frontal theta/beta ratio (a broadly used index that reflects prefrontally-mediated top–down processes, which might indicate better control over subcortical information). Furthermore, we expected the perseverance of effort facet of grit to be linked to higher complexity during task engagement because previous research has shown complexity indexes (entropy and fractal dimension) to be linked to effort while performing cognitive tasks. Our results revealed that although there were no differences at rest as a function of grit, the participants with high grit and high consistency of interest scores exhibited lower frontal theta/beta ratios during the learning task. This pattern suggests that individual differences in grit might be more evident when top-down control processes are at work. Furthermore, there was a positive association between perseverance of effort and entropy at task, which might indicate more effort and engagement in the task. Finally, no association was found between the neural indexes (frontal theta/beta ratio, entropy, or fractal dimension) and impulsiveness, neither impulsiveness mediated between grit and brain measures. Finally, when controlling for impulsiveness and demographic variables (gender, age, education, and work experience) the effects at the facet level remained statistically significant. While there is still a long way to fully understand the neural mechanisms of grit, the present work constitutes a step toward unveiling the electrophysiological prints of grit.
Preponderance of blaKPC-Carrying Carbapenem-Resistant Enterobacterales Among Fecal Isolates From Community Food Handlers in Kuwait

Carbapenem-resistant Enterobacterales (CRE) are pathogens that have been found in several countries, with a significant public health concern. Characterizing the mode of resistance and determining the prevailing clones are vital to the epidemiology of CRE in our community. This study was conducted to characterize the molecular mode of resistance and to determine the clonality of the CRE fecal isolates among community food handlers (FHs) vs. infected control patients (ICPs) in Kuwait. Fecal CRE isolates obtained from FHs and ICPs from September 2016 to September 2018 were analyzed for their resistance genes. Gene characterization was carried out by polymerase chain reaction (PCR) assays and sequencing. Clonality of isolates was established by multilocus sequence typing (MLST). Of the 681 and 95 isolates of the family Enterobacterales isolated from FHs and ICPs, 425 (62.4%) and 16 (16.8%) were Escherichia coli, and 18 (2.6%) and 69 (72.6%) were Klebsiella pneumoniae, respectively. A total of 36 isolates were CRE with a prevalence of 5.3% among FH isolates and 87 (91.6%) among the ICPs. Of these, carbapenemase genes were detected in 22 (61.1%) and 65 (74.7%) isolates, respectively (p < 0.05). The detected specific genes among FHs and ICPs were positive for blaKPC 19 (86.4%) and 35 (40.2%), and blaOXA 10 (45.5%) and 59 (67.8%), in addition to blaNDM 2 (9.1%) and 32 (36.8%), respectively. MLST assays of the E. coli and K. pneumoniae isolates revealed considerable genetic diversity and polyclonality as well as demonstrated multiple known ST types and eight novel sequence types. The study revealed a relatively high number of CRE harboring predominantly blaKPC-mediated CRE among the community FH isolates vs. predominant blaOXA genes among the ICPs. Those heterogeneous CRE isolates raise concerns and mandate more efforts toward molecular surveillance. A multinational study is recommended to monitor the spread of genes mediating CRE in the community of Arabian Peninsula countries.
Nematode Interactions on Beetle Hosts Indicate a Role of Mouth-Form Plasticity in Resource Competition

Competition is rampant across kingdoms, arising over potential mates, food resources, and space availability. When faced with opponents, phenotypic plasticity proffers organisms indispensable advantageous strategies to outcompete rivals. This tactic is especially crucial on decaying insect hosts as myriad microbes and numerous nematodes struggle to establish thriving populations and ensure resource availability for future generations. Scarab beetles and their associated nematode symbionts on La Réunion Island have provided exceptional systems to study complicated cross-phylum interactions in soil, and recently we have identified a previously unexplored beetle host, Gymnogaster bupthalma, to be reliably co-infested with diplogastrids Pristionchus mayeri and Acrostichus spp. These nematodes maintain the capacity to plastically respond to environmental conditions by developing disparate mouth forms, a strict bacterial-feeding morph or an omnivorous morph that enables predation on other nematodes. In addition, under stressful settings these worms can enter an arrested development stage called dauer, non-feeding dispersal larvae that resume development into reproducing adults when conditions improve. By investigating this beetle-nematode system in a natural context, we uncovered a novel Pristionchus strategy, wherein dauer dispersal from the carcass is gradual and a reproducing population is sustained. Remarkably, usually preferential-bacterial morph P. mayeri develop as predators in populations dense with competitors.
Perceptual Awareness Negativity—Does It Reflect Awareness or Attention?

Identifying the neural correlates of consciousness (NCC) is one of the most important endeavors in neuroscience. A key debate concerns the question whether conscious experience is generated by the early activity of the sensory cortex, or rather by later activity of the supra-modal parietal and frontal cortices. Initial research using the event-related potentials (ERP) technique supported the “late” view, with many studies concluding that the P3b ERP component a positive wave occurring over centro-parietal regions around 300–500ms after the stimulus reflects the mechanism of consciousness (review: Dehaene and Changeux, 2011). However, more recent work reveals, first, that some clearly perceived stimuli do not evoke P3b, meaning this component is not necessary for consciousness; and second, that P3b can be evoked or modulated by subliminal stimuli, which indicates it is not sufficient either. Along with this evidence challenging P3b as NCC, several lines of research have provided strong support for the “early” view. Specifically, a growing body of evidence shows that becoming aware of a stimulus is reliably associated with a negative-going ERP component observed as early as 150–250ms after the stimulus onset over the modality-specific sensory regions. Such awareness-related negative components have been found in visual, auditory, and somatosensorymodalities, and therefore an overarching term Perceptual Awareness Negativity (PAN) has been recently proposed (Dembski et al., 2021). Recent progress in investigating the mechanisms of perceptual awareness using ERPs has been reviewed by Förster et al. (2020) and Dembski et al. (2021). Both reviews argue that there is enough evidence to falsify P3b as a marker of consciousness, and conclude that PAN is at present the best candidate for NCC. While we generally agree with their view, in this opinion piece we point out that a key challenge faced by the proponents of early NCC is disentangling mechanisms of consciousness from mechanisms of attention. Assuming that PAN reflects the phenomenal aspect of consciousness (Koivisto et al., 2017; Derda et al., 2019), which is by definition orthogonal to attention (Lamme, 2003), dissociating ERP correlates of both processes should be in principle possible. However, we think that conclusive evidence for such a dissociation has not been provided so far and, what is more, a body of data suggests PAN might be in fact closely related to attention.
Dynamics of Salivary Adenosine Deaminase, Haptoglobin, and Cortisol in Lipopolysaccharide-Challenged Growing Pigs

Infectious and inflammatory conditions are common especially in growing pigs. Lipopolysaccharide (LPS) is an important antigenic structure of Gram-negative bacteria and can be used to induce inflammation experimentally. As pigs are usually group-housed in commercial conditions, it is difficult to detect sick individuals, particularly at an early stage of illness. Acute phase proteins such as haptoglobin (Hp) are known indicators of an activated innate immune system whereas adenosine deaminase (ADA) is a relatively novel inflammatory biomarker in pigs. Both parameters can be measured in saliva and could be used as indicators of inflammation. Compared with blood sampling, saliva sampling is a less stressful procedure that is rapid, non-invasive and easy to perform both at group and at individual level. In this blinded randomized clinical trial, 32 female pigs at their post-weaning phase were allocated to one of four treatments comprising two injections of the following substance combinations: saline-saline (SS), ketoprofen-saline (KS), saline-LPS (SL), and ketoprofen-LPS (KL). First, ketoprofen or saline was administered intramuscularly on average 1 h before either LPS or saline was given through an ear vein catheter. In all groups, saliva was collected prior to injections (baseline) and at 4, 24, 48, and 72 h post-injection for determination of ADA, Hp, and cortisol concentrations. A multivariate model was applied to describe the dynamics of each biomarker. Pairwise relationships between ADA, Hp, and cortisol responses from baseline to 4 h post-injection within the SL group were studied with Spearman correlations. A significant increase in the SL group was seen in all biomarkers 4 h post-injection compared to baseline and other time points (pairwise comparisons, p < 0.01 for all) and ketoprofen alleviated the LPS effect. We found a significant positive correlation between ADA and Hp within the SL group (r = 0.86, p < 0.05). The primary and novel findings of the present study are the response of ADA to LPS, its time course and alleviation by ketoprofen. Our results support the evidence that ADA and Hp can be used as inflammatory biomarkers in pigs. We suggest further studies to be conducted in commercial settings with larger sample sizes.
Psychological Status of High School Students 1 Year After the COVID-19 Emergency

Background: With the control of the epidemic, adolescents' mental outlook might have improved. However, little evidence existed with regard to the psychological status of adolescents in post-COVID-19 era. This present study aimed to explore the psychological status of high school students after the epidemic getting eased. Methods: A web-based cross-sectional survey was used to obtain data from three high schools, including the demographic information, the Patient Health Questionnaire-9 (PHQ-9), the Generalized Anxiety Disorder-7 (GAD-7), the Self-Rating Scale of Sleep (SRSS), and self-designed general recent-status questionnaire. Correlation analysis was performed to explore potential associations between the depression symptoms, anxiety symptoms, and sleep status. The PHQ-9 and GAD-7 differences between nowadays data and the data enrolled 12 months before were also compared. Result: A total of 1,108 qualified questionnaires were obtained. The prevalence of depressive and anxious symptoms was 27.5 and 21.3%, respectively, from mild to severe in all students, while 11.8% of these high students got sleep disturbances. Both the rate and the severity of depression, anxiety and sleep problems of female students were higher than male students. Grade three students suffered higher prevalence and severer mental disturbances than the other two grades. There were significant correlations between the depression symptoms, anxiety symptoms, and sleep status. The psychological status has been improved in nowadays high school students compared with the sample enrolled 12 months before. Conclusion: As a supplement to our former study, this present research provided a perspective on the psychological status of high school students 1 year after the COVID-19 pandemic being well controlled. We should pay attention to the psychological status of high school students, and should also notice the progresses made by this special group after the epidemic.
Comparing the Impact of Nature, Blended, and Traditional Preschools on Children’s Resilience: Some Nature May Be Better Than None

This study examined the effect of nature preschools on the development of key protective factors associated with psychological resilience. The Deveraux Early Childhood Assessment for Preschoolers, Second Edition (DECA-P2), was used to assess the growth in the protective factors of initiative, self-regulation, and attachment in 87 children who attended nature, blended, and traditional preschool classes within the same school district. Study results suggest that nature preschool participation was important in the context of initiative. Blended classes, where some nature-based practices were incorporated into traditional preschool classes, were sufficient in the sense of being more impactful than traditional classes on self-regulation, attachment, and the total protective factors overall. Implications are discussed within the context of the limitations of the study.