Miracle-dz/UniFAR-FTUs huggingface dataset:
Enhancing the Sensitivity of Nanoplasmonic Thin Films for Ethanol Vapor Detection

Nanoplasmonic thin films, composed of noble metal nanoparticles (gold) embedded in an oxide matrix, have been a subject of considerable interest for Localized Surface Plasmon Resonance (LSPR) sensing. Ethanol is one of the promising materials for fuel cells, and there is an urgent need of a new generation of safe optical sensors for its detection. In this work, we propose the development of sensitive plasmonic platforms to detect molecular analytes (ethanol) through changes of the LSPR band. The thin films were deposited by sputtering followed by a heat treatment to promote the growth of the gold nanoparticles. To enhance the sensitivity of the thin films and the signal-to-noise ratio (SNR) of the transmittance–LSPR sensing system, physical plasma etching was used, resulting in a six-fold increase of the exposed gold nanoparticle area. The transmittance signal at the LSPR peak position increased nine-fold after plasma treatment, and the quality of the signal increased six times (SNR up to 16.5). The optimized thin films seem to be promising candidates to be used for ethanol vapor detection. This conclusion is based not only on the current sensitivity response but also on its enhancement resulting from the optimization routines of thin films’ architectures, which are still under investigation.
Immunology in the Era of Single-Cell Technologies.

Immune cells are characterized by diversity, specificity, plasticity, and adaptability-properties that enable them to contribute to homeostasis and respond specifically and dynamically to the many threats encountered by the body. Single-cell technologies, including the assessment of transcriptomics, genomics, and proteomics at the level of individual cells, are ideally suited to studying these properties of immune cells. In this review we discuss the benefits of adopting single-cell approaches in studying underappreciated qualities of immune cells and highlight examples where these technologies have been critical to advancing our understanding of the immune system in health and disease. Expected final online publication date for the Annual Review of Immunology, Volume 38 is April 26, 2020. Please see http://www.annualreviews. org/page/journal/pubdates for revised estimates.
A Multifaceted Explanation of the Predisposition to Buy Organic Food

This study explores whether implicit and explicit attitudes toward organic products explain consumers’ predisposition to buy organic food, considering the hedonic and utilitarian dimensions of attitudes. The data are from an online survey, which included a section on implicit attitudes (measured using an Implicit Association Test) and a section on explicit attitudes. Two products were analyzed using 557 responses from a panel of consumers: chocolate (hedonic-oriented food) and milk (a utilitarian-oriented food). Confirmatory factor analysis and multigroup structural equations were applied to assess the proposed model. Three findings may be highlighted. First, in the model with the lowest entropy, the hedonic and utilitarian dimensions are considered to be independent. Second, different types of attitudes play different roles depending on the product. Finally, implicit attitudes influence the predisposition to buy organic food in the case of pleasure-seeking food but not utilitarian-oriented food. Thus, there is convergence between implicit and explicit attitudes for hedonic-oriented foods and divergence between such attitudes for utilitarian-oriented foods. This study’s value lies in the novel use of implicit attitudes, which have generally been neglected in attitudinal models in the organic food domain.
Development of a Wellness Committee Implementation Index for Workplace Health Promotion Programs in Small Businesses

Purpose: To construct a wellness committee (WC) implementation index and determine whether this index was associated with evidence-based intervention implementation in a workplace health promotion program. Design: Secondary data analysis of the HealthLinks randomized controlled trial. Setting: Small businesses assigned to the HealthLinks plus WC study arm. Sample: Small businesses (20-200 employees, n = 23) from 6 low-wage industries in King County, Washington. Measures: Wellness committee implementation index (0%-100%) and evidence-based intervention implementation (0%-100%). Analysis: We used descriptive and bivariate statistics to describe worksites’ organizational characteristics. For the primary analyses, we used generalized estimating equations with robust standard errors to assess the association between WC implementation index and evidence-based intervention implementation over time. Results: Average WC implementation index scores were 60% at 15 months and 38% at 24 months. Evidence-based intervention scores among worksites with WCs were 27% points higher at 15 months (64% vs 37%, P < .001) and 36% points higher at 24 months (55% vs 18%, P < .001). Higher WC implementation index scores were positively associated with evidence-based intervention implementation scores over time (P < .001). Conclusion: Wellness committees may play an essential role in supporting evidence-based intervention implementation among small businesses. Furthermore, the degree to which these WCs are engaged and have leadership support, a set plan or goals, and multilevel participation may influence evidence-based intervention implementation and maintenance over time.
Irradiation with Polychromatic Incoherent Low Energy Radiation of Human Peripheral Blood Mononuclear Cells In Vitro: Effects on Cytokine Production

(1) Background: Physical stimuli may activate peripheral blood mononuclear cells (PBMCs) to secrete cytokines, which may favor pro-inflammatory responses or trigger reparative phenomena. The purpose of this study is to evaluate the action of Polarized Polychromatic Incoherent Low Energy Radiation (PILER) on human in vitro PBMCs, by detection of the possible effects on cytokine production; (2) Methods: isolated PBMCs were irradiated with a PILER lamp at different exposure times, at a distance of 10 cm, before incubation. The supernatants were collected after 24 h and 48 h and cytokines evaluated by ELISA; (3) Results: Our results showed a decrease in the levels of pro-inflammatory IL-12p70, IL-17A, IFN-γ, and TNF-α cytokines, whereas IL-10 and TGF-β1 with regulatory activity increased; (4) Conclusions: PILER irradiation affected the cytokine production by isolated PBMCs driving the immune response toward an anti-inflammatory/reparative profile.
A Review of Qualitative Research of Perception and Experiences of Dementia Among Adults From Black, African, and Caribbean Background: What and Whom Are We Researching?

Abstract Background and Objectives Black, African, and Caribbean (BAC) families are disproportionately affected by dementia but engage less with services. Studies reporting their experiences of dementia have tended to aggregate people from diverse backgrounds, without considering the impact of this diversity, or researchers’ ethnicities. We investigated participants’ and researchers’ ethnic identities, exploring how this relates to findings. Research Design and Methods We searched electronic databases in September 2018, for qualitative studies exploring how participants of Black ethnicity understand and experience dementia and dementia care. We reported participants’ and researchers’ ethnicities, and meta-synthesized qualitative findings regarding how ethnicity influences experiences and understanding of dementia. Results Twenty-eight papers reported 25 studies; in United States (n = 17), United Kingdom (n = 7), and Netherlands (n = 1). 350/492 (71%) of participants were in U.S. studies and described as African American; participants in U.K. studies as Caribbean (n = 45), African/Caribbean (n = 44), African (n = 28), Black British (n = 7), or Indo-Caribbean (n = 1); and in Netherlands as Surinamese Creole (n = 17). 6/25 (24%) of studies reported involving recruiters/interviewers matching participants’ ethnicity; and 14/25 (56%) involved an author/advisor from a BAC background during analysis/procedures. We identified four themes: Dementia does not relate to me; Inappropriate and disrespectful services; Kinship and responsibility; Importance of religion. Discussion and Implications Studies were mostly from a U.S. African American perspective, by researchers who were not of BAC background. Themes of dementia diagnosis and services feeling less relevant to participants than the majority population resonated across studies. We caution against the racialization of these findings, which can apply to many differing minority groups.
Association of serum FGF-23, klotho, fetuin-A, osteopontin, osteoprotegerin and hs-CRP levels with coronary artery disease

Abstract Environmental, genetic, oxidative and biochemical factors play an important role in the atherosclerotic process. We investigated the association of serum fibroblast growth factor (FGF-23), klotho, fetuin-A, osteoprotegerin (OPG), osteopontin (OPN) and high-sensitive-CRP (Hs-CRP) markers with coronary artery disease and whether one was superior to others or not. A study group of 52 patients with coronary artery disease (CAD) and a control group of 30 patients with angiographically normal epicardial coronary arteries were included in the study. Serum FGF-23, klotho, fetuin-A, OPN, OPG and Hs-CRP marker levels were studied. Patients with CAD were classified in two groups as low (SYNTAX ≤22, n = 29) and moderate-high (SYNTAX ≥ 23, n = 23) according to anatomic SYNTAX score. FGF-23 (p = .033), klotho (p < .001), fetuin-A (p = .005) and OPG (p = .001) serum marker levels were significantly lower in CAD patients than the control group. Serum levels of FGF-23 (p = .012), klotho (p = .001), fetuin-A (p = .015) and OPG (p = 0.002) were significantly different between SYNTAX tertiles and control group. Klotho (p = .025, odd ratio (OR) = 0.542, 95% confidence interval (CI): 0.317–0.926) and HT (p = .004, OR = 34.598, 95%CI:1.054–1135.657) were the independent predictors of CAD presence. Serum klotho levels of 91.48 pmol/L predicts the presence of CAD with 60% sensitivity and 96.55% specificity (p < .001, area under curve = 0.864, 95% CI = 0.768, 0.931). We found that serum klotho level is an independent predictor of presence, extent and severity of CAD.
Clinical findings in a group of patients infected with the 2019 novel coronavirus (SARS-Cov-2) outside of Wuhan, China: retrospective case series

Abstract Objective To study the clinical characteristics of patients in Zhejiang province, China, infected with the 2019 severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) responsible for coronavirus disease 2019 (covid-2019). Design Retrospective case series. Setting Seven hospitals in Zhejiang province, China. Participants 62 patients admitted to hospital with laboratory confirmed SARS-Cov-2 infection. Data were collected from 10 January 2020 to 26 January 2020. Main outcome measures Clinical data, collected using a standardised case report form, such as temperature, history of exposure, incubation period. If information was not clear, the working group in Hangzhou contacted the doctor responsible for treating the patient for clarification. Results Of the 62 patients studied (median age 41 years), only one was admitted to an intensive care unit, and no patients died during the study. According to research, none of the infected patients in Zhejiang province were ever exposed to the Huanan seafood market, the original source of the virus; all studied cases were infected by human to human transmission. The most common symptoms at onset of illness were fever in 48 (77%) patients, cough in 50 (81%), expectoration in 35 (56%), headache in 21 (34%), myalgia or fatigue in 32 (52%), diarrhoea in 3 (8%), and haemoptysis in 2 (3%). Only two patients (3%) developed shortness of breath on admission. The median time from exposure to onset of illness was 4 days (interquartile range 3-5 days), and from onset of symptoms to first hospital admission was 2 (1-4) days. Conclusion As of early February 2020, compared with patients initially infected with SARS-Cov-2 in Wuhan, the symptoms of patients in Zhejiang province are relatively mild.
Cost-effectiveness of the triple procedure - phacovitrectomy with posterior capsulotomy compared to phacovitrectomy and sequential procedures.

PURPOSE To evaluate the cost-effectiveness of the triple procedure (phacovitrectomy + posterior capsulotomy, PhacoPPVc) compared to the double- (phacovitrectomy, PhacoPPV) or single sequential procedures. METHODS Prospective study on 31 eyes from 31 patients (mean age: 72.1 ± 9.1 years; 55% females) was performed with a preoperative decision to undergo only pars plana vitrectomy (PPV) (26%) or PhacoPPV (74%) and/or posterior capsulotomy based upon presence or absence of lens opacification or pseudophakia. Time during and between surgeries, surgical procedure codes, medical and transport costs, outcome and likelihood of complications after surgery were all included in the analysis. Societal perspectives and visual acuity were considered as measures of quality of adjusted life years (QALYs). RESULTS About 23 eyes underwent triple procedure and eight eyes underwent vitrectomy only (mean surgery times: 35.9 and 24.0 min, respectively). Posterior capsulotomy took on average 30 s, while preparation and cataract procedure took 13.0 min. The patients travelled on average 80km (average cost: $280.12) to the surgery unit. The average reimbursement fee for the day procedures ranged between $174.17 (YAG capsulotomy; Diagnosis Related Group (DRG): 0.034), $1045.48 (Phaco + intraocular lens (IOL); DRG: 0.204) and $1701.32 (PPV; DRG: 0.332). The combined procedures excluded lens and laser reimbursements, while the calculated reimbursements for the double/triple procedures were $2713.08/$2901.45, respectively, without significant loss of QALYs. PhacoPPVc was found to be unequivocally cost-effective, while PhacoPPV remained cost saving compared to sequential procedures. CONCLUSION This study confirms that the triple procedure has benefits to the patients, health institution and surgeon. For patients, it saves them travel and healing time; for health institution, it justifies the calculated higher costs and need for higher reimbursement for the double/triple procedures, which are cost saving.
A novel Epstein‐Barr virus subtype associated with nasopharyngeal carcinoma found in South China

Nasopharyngeal carcinoma (NPC) is a unique malignancy closely associated with Epstein-Barr virus (EBV) infection and with a restricted geographical distribution [1]. According to a recent World Health Organization (WHO) report, there were around 129,000 new NPC cases reported worldwide in 2018 with greater than 70% of cases in South China and Southeast Asia [2]. In Hong Kong and Guangdong in South China, NPC incidence is as high as 12.8-25.0/ 100,000 per year [1, 2]. Known risk factors for NPC include a family history of NPC, genetic susceptibility, EBV infection, and environmental factors such as smoking and salted fish consumption [3]. However, previous studies have found that several traditionally accepted risk factors are at most weakly and perhaps not causally associated with contemporary NPC risk [1, 3]. In addition, host genetic factors explain less than 15% of the phenotypic variance [1, 3]. Thus, the cause of NPC endemicity remains enigmatic. EBV was the first human tumor virus to be discovered. Originally found in the tumor cells of Burkitt lymphoma, a common childhood B-cell malignancy in sub-Saharan Africa. EBV has subsequently been implicated in the etiology of predominantly B-cell lymphomas (particularly in immunosuppressed individuals) as well as carcinomas such as NPC and gastric adenocarcinomas [4]. The tropism of EBV for B lymphocytes and epithelial cells reflects the natural history of normal virus infection whereby EBV establishes lifelong persistence in the memory B cell population of healthy
Variational Inference for DPGMM with Coresets

Performing estimation and inference on massive datasets under time and memory constraints is a critical task in machine learning. One approach to tackle these challenges is offered by coresets, succinct data summaries that come with strong theoretical guarantees, and can operate under computational resource restrictions. In this work, we explore how such data summaries can be used in posterior inference through variational methods. We develop a novel coreset construction for approximate posterior inference in the nonparametric Dirichlet process Gaussian mixture model. We empirically demonstrate how our method allows trading small approximation error for large gains in runtime and memory usage.
Epigenetic modification-related mechanisms of hepatocellular carcinoma resistance to immune checkpoint inhibition

Hepatocellular carcinoma (HCC) constitutes most primary liver cancers and is one of the most lethal and life-threatening malignancies globally. Unfortunately, a substantial proportion of HCC patients are identified at an advanced stage that is unavailable for curative surgery. Thus, palliative therapies represented by multi-tyrosine kinase inhibitors (TKIs) sorafenib remained the front-line treatment over the past decades. Recently, the application of immune checkpoint inhibitors (ICIs), especially targeting the PD-1/PD-L1/CTLA-4 axis, has achieved an inspiring clinical breakthrough for treating unresectable solid tumors. However, many HCC patients with poor responses lead to limited benefits in clinical applications, which has quickly drawn researchers’ attention to the regulatory mechanisms of immune checkpoints in HCC immune evasion. Evasion of immune surveillance by cancer is attributed to intricate reprogramming modulation in the tumor microenvironment. Currently, more and more studies have found that epigenetic modifications, such as chromatin structure remodeling, DNA methylation, histone post-translational modifications, and non-coding RNA levels, may contribute significantly to remodeling the tumor microenvironment to avoid immune clearance, affecting the efficacy of immunotherapy for HCC. This review summarizes the rapidly emerging progress of epigenetic-related changes during HCC resistance to ICIs and discusses the mechanisms of underlying epigenetic therapies available for surmounting immune resistance. Finally, we summarize the clinical advances in combining epigenetic therapies with immunotherapy, aiming to promote the formation of immune combination therapy strategies.
Development of a novel pyroptosis-related LncRNA signature with multiple significance in acute myeloid leukemia

Background: Pyroptosis, a programmed cell death (PCD) with highly inflammatory form, has been recently found to be associated with the origin of hematopoietic malignancies. Long noncoding RNA (lncRNA) had emerged as an essential mediator to regulate gene expression and been involved in oncogenesis. However, the roles of pyroptosis-related lncRNA (PRlncRNA) in acute myeloid leukemia (AML) have not yet been completely clarified. Methods: We collected AML datasets from public databases to obtain PRlncRNA associated with survival and constructed a PRlncRNA signature using Lasso-Cox regression analysis. Subsequently, we employed RT-PCR to confirm its expression difference and internal training to further verify its reliability. Next, AML patients were classified into two subgroups by the median risk score. Finally, the differences between two groups in immune infiltration, enrichment analysis and drug sensitivity were further explored. Results: A PRlncRNA signature and an effective nomogram combined with clinicopathological variables to predict the prognosis of AML were constructed. The internal validations showed that the PRlncRNA risk score model was an accurate and productive indicator to predict the outcome of AML. Furthermore, this study indicated that higher inflammatory cell and immunosuppressive cells, and less sensitive to conventional chemotherapy drugs were highlighted in the high-risk group. Conclusion: Through comprehensive analysis of PRlncRNA model, our study may offer a valuable basis for future researches in targeting pyroptosis and tumor microenvironment (TME) and provide new measures for prevention and treatment in AML.
A mixed methods study of the teachers’ self-efficacy views and their ability to improve self-efficacy beliefs during teaching

Objective The current study has the aim of investigating teachers’ views about their self-efficacy and how they improve their self-efficacy beliefs during teaching practice. Methods The study was designed in a mixed methods research design. “Teacher’s Self-Efficacy Scale,” “Personal Information Form” and “Semi-structured Interview Form” were employed in the study. The quantitative data were collected from 379 teachers in public schools in the 2021–2022 academic year, whereas the qualitative data were obtained from the top 10 participants with the highest level of self-efficacy. Results and Discussion Based on the qualitative and quantitative results of the present study, it was revealed that teachers’ self-efficacy levels were high, and they felt self-efficient in their teaching.The study is of great importance since determining teachers’ opinions about their self-efficacy beliefs and how they improve their self-efficacy beliefs in the solution of the problems they encountered during teaching practice will not only raise awareness of the importance of self-efficacy in teaching profession, but will contribute to further research and qualified teacher training.
Spread determinants in corporate bond pricing: The effect of market and liquidity risks

This paper investigates the effect of market and liquidity risks on corporate bond pricing in Turkey, an emerging market, and in Europe. Results show that corporate bond returns have exposure to liquidity factors and not to market factors in both settings. Corporate bonds issued in Turkey have significant exposure to fluctuations in benchmark treasury bond liquidity and corporate bond market liquidity; while corporate bonds issued in Eurozone have exposure to equity market liquidity and are sensitive to fluctuations in a 10-year generic government bond liquidity. The total estimated liquidity risk premium is 0.7% per annum for Turkish “A” and above graded corporate bonds, and 1.08% for the last investment grade level (BBB-) long term bonds. For Eurozone, the total liquidity risk premium is 0.27% for investment grade 5-10 year term bonds, 1.05% for high-yield 1-5 year term bonds and 1.02% for high-yield 5-10 year term category. Key words: Corporate bond, Liquidity risk, Credit spread, Risk premium. JEL: G12, G13.
DropTES 2018 Final Experiment Report Interaction of laser exposed medicine droplets with target surfaces under microgravity conditions

The interaction of UV laser radiation with pendant medicine droplets and their wetting properties on target surfaces has been investigated under the aegis of the United Nations Office for Outer Space Affairs (UNOOSA) within the Drop Tower Experiment Series (DropTES) Fellowship Programme. Experiments were conducted in microgravity conditions at Bremen Drop Tower, sponsored by the German Aerospace Center (DLR) Space Administration and the Center of Applied Space Technology and Microgravity (ZARM). The DropTES 2018 experiment aimed to bring a new insight on the behaviour of medicine droplets in reduced gravitational environment. A novel aspect of the project represented droplets real time exposure and modification by UV laser beam, leading to new photoproducts with antimicrobial properties. The obtained droplets have been afterwards brought in contact with an aluminium target surface in order to study the evolution of wetting phenomena. Since microorganisms can evolve into more virulent forms under microgravity conditions, astronauts and spacecraft surfaces may require treatment and decontamination, respectively, against onboard pathogens.