Miracle-dz/UniFAR-FTUs huggingface dataset:
New Therapy Options for Neuroendocrine Carcinoma of the Pancreas—The Emergent Substance GP-2250 and Gemcitabine Prove to Be Highly Effective without the Development of Secondary Resistances In Vitro and In Vivo

Simple Summary Neuroendocrine carcinoma of the pancreas is a highly aggressive form of neuroendocrine tumor associated with poor survival and increasing occurrence. GP-2250 is an emergent substance showing antineoplastic properties, especially in combination with Gemcitabine. This study was the first to evaluate the antineoplastic effects of GP-2250 on pancreatic neuroendocrine carcinoma. The combination of GP-2250 and Gemcitabine showed highly synergistic effects in a cell culture model, as well as in mice, without the development of secondary resistances. These findings form the basis for further clinical evaluation of a highly promising combination therapy. Abstract Neuroendocrine carcinoma of the pancreas (pNEC) is an aggressive form of neuroendocrine tumor characterized by a rising incidence without an increase in survival rates. GP-2250 is an oxathiazinane derivate possessing antineoplastic effects, especially in combination with Gemcitabine on the pancreatic adenocarcinoma. The cytotoxic effects of the monotherapy of GP-2250 (GP-2250mono) and Gemcitabine (Gemmono), as well as the combination therapy of both, were studied in vitro using an MTT-assay on the QGP-1 and BON-1 cell lines, along with in vivo studies on a murine xenograft model of QGP-1 and a patient-derived xenograft model (PDX) of Bo99. In vitro, Gemmono and GP-2250mono showed a dose-dependent cytotoxicity. The combination of GP-2250 and Gemcitabine exhibited highly synergistic effects. In vivo, the combination therapy obtained a partial response in QGP-1, while GP-2250mono and Gemmono showed progressive disease or stable disease, respectively. In Bo99 PDX, the combination therapy led to a partial response, while the monotherapy resulted in progressive disease. No development of secondary resistances was observed, as opposed to monotherapy. This study was the first to evaluate the effects of the emerging substance GP-2250 on pNEC. The substance showed synergism in combination with Gemcitabine. The combination therapy proved to be effective in vitro and in vivo, without the development of secondary resistances.
Modelling and circuit design for STT-MRAM

This thesis presents three research contributions in the areas of modelling, circuit-level design, and device-level design of spin-transfer-torque magnetoresistive random access memory (STT-MRAM). Accurate modelling of Magnetic Tunnel Junction (MTJ) is critical for design of STTMRAM and spin-logic circuits such as spin flip flops. This thesis reviews several static and dynamic models for the MTJ and compares them against a proposed model in Verilog-A model. The proposed model is used in simulating the proposed circuits and devices in the latter part of this thesis. In circuit level, we propose adding an STT-MRAM to a Static Random Access Memory (SRAM) cell to produce an MRAM-backed-SRAM cell for nonvolatile FieldProgrammable Gate Array (FPGA). The proposed cell reduces the time to reconfigure the FPGA following power-down, and enables fast wake-ups and power-gating. With the proposed restore operation, data is recalled with no error even in the presence of mismatch. Simulation results confirm that data can be stored in the proposed cell in 80ns and restored in less than 1ns. At device level, a multi-level cell (MLC) for STT-MRAM is proposed using biaxial Magnetic Tunnel Junction (MTJ). The proposed cell consists of 1Transistor-1MTJ
Nationwide trends and outcomes of neoadjuvant chemotherapy in pancreatic cancer – an analysis of the Swedish national pancreatic cancer registry

Abstract Objectives During the last decade, neoadjuvant therapy (NAT) for pancreatic cancer has become more frequent. Pathological response and overall survival are promising; however, various post-operative complications have been reported. Our primary aim was to compare the complication scenario of patients receiving NAT in borderline resectable and locally advanced disease with those who had upfront pancreatic surgery (UFS) for primarily resectable cancer. Methods From the Swedish National Pancreatic and Periampullary Cancer Registry, patients resected for pancreatic ductal adenocarcinoma (PDAC) between 2010 and 2018 were identified. Data on patient characteristics, neoadjuvant therapy, post-operative complications and survival were obtained. Comparisons between groups as well as survival analysis were performed. Results Within the total cohort of 13,948 patients, 1894 (median age 69 years, 51% men) were resected for PDAC. Among these, 112 (5.9%) patients received NAT followed by surgery. The patients who received NAT were younger (67 vs 70 years, p < .001), had a lower level of CA19-9 (47 vs 108, p = .001) and had to a larger extent vascular resection (58.9 vs 26.9%, p < .001) and total pancreatectomy performed (23.2 vs 9.1%, p < .001). No difference was found for major post-operative complications and there was no significant change in survival rate between the NAT and UFS groups (median 28 vs 26 months, p = .122). Conclusions When analyzing data from a national registry, no difference in post-operative complications was found between resected patients receiving UFS and NAT for PDAC. Also, the survival was equal between groups. NAT is a feasible treatment option for patients with potentially curable pancreatic cancer.
Nexus between Capital Flows and Economic Growth: An Evidence from South Asian Countries

This study aims to look at how capital inflows affect economic growth in South Asian countries. Gross Domestic Savings (GDS), Foreign Direct Investment (FDI), Foreign Portfolio Equity Investment (FPEI), Foreign Debts (F.Debts), and Foreign Aids (F.Aids) are the study's independent variables, while Gross Domestic Product Growth (GDPG) is the dependent variable. Data has been collected from World development Indicator and Quandl from 1980 to 2018. To analyse the data Panel ARDL (PMG) model was utilised. Gross domestic savings, foreign direct investment, and foreign aid, all exhibit positive and strong long-term connections with GDP growth. Results also revealed that there are negative and strong long-run links between GDP, Foreign Portfolio Equity Investment, and Foreign Aids. There are negative and insignificant links between GDP growth, Foreign Direct Investment, and Foreign Aids. Results also reveal the positive and insignificant connections between GDP and GDS, FPEI, and foreign debt. The data imply that institutional improvement has an impact on capital inflows and economic growth. The study has policy implications for government and policymakers in the sense that capital flows and economic growth can improve the institutional environment.
Alleviation of Oral Exposure to Aflatoxin B1-Induced Renal Dysfunction, Oxidative Stress, and Cell Apoptosis in Mice Kidney by Curcumin

Aflatoxin B1 is a contaminant widely found in food and livestock feed, posing a major threat to human and animal health. Recently, much attention from the pharmaceutical and food industries has been focused on curcumin due to its strong antioxidant capacity. However, the therapeutic impacts and potential mechanisms of curcumin on kidney damage caused by AFB1 are still incomplete. In this study, AFB1 triggered renal injury in mice, as reflected by pathological changes and renal dysfunction. AFB1 induced renal oxidative stress and interfered with the Keap1–Nrf2 pathway and its downstream genes (CAT, SOD1, NQO1, GSS, GCLC, and GCLM), as manifested by elevated oxidative stress metabolites and reduced antioxidant enzymes activities. Additionally, AFB1 was found to increase apoptotic cells percentage in the kidney via the TUNEL assay, along with increased expression of Cyt-c, Bax, cleaved-Caspase-3, Caspase-9, and decreased expression of Bcl-2 at the transcriptional and protein levels; in contrast, for mice given curcumin, there was a significant reversal in kidney coefficient, biochemical parameters, pathological changes, and the expression of genes and proteins involved in oxidative stress and apoptosis. These results indicate that curcumin could antagonize oxidative stress and apoptosis to attenuate AFB1-induced kidney damage.
Detecting Abnormal Axillary Lymph Nodes on Mammograms Using a Deep Convolutional Neural Network

The purpose of this study was to determine the feasibility of a deep convolutional neural network (dCNN) to accurately detect abnormal axillary lymph nodes on mammograms. In this retrospective study, 107 mammographic images in mediolateral oblique projection from 74 patients were labeled to three classes: (1) “breast tissue”, (2) “benign lymph nodes”, and (3) “suspicious lymph nodes”. Following data preprocessing, a dCNN model was trained and validated with 5385 images. Subsequently, the trained dCNN was tested on a “real-world” dataset and the performance compared to human readers. For visualization, colored probability maps of the classification were calculated using a sliding window approach. The accuracy was 98% for the training and 99% for the validation set. Confusion matrices of the “real-world” dataset for the three classes with radiological reports as ground truth yielded an accuracy of 98.51% for breast tissue, 98.63% for benign lymph nodes, and 95.96% for suspicious lymph nodes. Intraclass correlation of the dCNN and the readers was excellent (0.98), and Kappa values were nearly perfect (0.93–0.97). The colormaps successfully detected abnormal lymph nodes with excellent image quality. In this proof-of-principle study in a small patient cohort from a single institution, we found that deep convolutional networks can be trained with high accuracy and reliability to detect abnormal axillary lymph nodes on mammograms.
The Antioxidant Activity of Thymus serpyllum Extract Protects against the Inflammatory State and Modulates Gut Dysbiosis in Diet-Induced Obesity in Mice

Nowadays, there is an increasing interest in alternative therapies in the treatment of metabolic syndrome that combine efficacy and safety profiles. Therefore, this study aimed to evaluate the effect of an extract of Thymus serpyllum, containing rosmarinic acid, on high-fat diet (HFD)-induced obesity mice, highlighting the impact of its antioxidant activity on the inflammatory status and gut dysbiosis. The extract was administered daily (50, 100 and 150 mg/kg) in HFD-fed mice. The treatment reduced body weight gain, glucose and lipid metabolic profiles. Moreover, the extract ameliorated the inflammatory status, with the c-Jun N-terminal kinases (JUNK) pathway being involved, and showed a significant antioxidant effect by the reduction of radical scavenging activity and the mitigation of lipid peroxidation. Moreover, the extract was able to modulate the altered gut microbiota, restoring microbial richness and diversity, and augmenting the counts of short-chain fatty acid producing bacteria, which have been associated with the maintenance of gut permeability and weight regulation. In conclusion, the antioxidant activity of Thymus serpyllum extract displayed a positive impact on obesity and its metabolic alterations, also reducing systemic inflammation. These effects may be mediated by modulation of the gut microbiota.
The Antifungal Activity of Cinnamon-Litsea Combined Essential Oil against Dominant Fungal Strains of Moldy Peanut Kernels

The antifungal activity of cinnamon (Cinnamomum cassia Presl), litsea [Litsea cubeba (Lour.) Pers. ], clove (Syzygium aromaticum L.), thyme (Thymus mongolicus Ronn.) and citronella (Cymbopogon winterianus Jowitt) essential oils (EOs) against the dominant fungi isolated from moldy peanuts was investigated in this research. Firstly, strain YQM was isolated and identified by morphological characterization and 18S rRNA gene sequence analysis to be Aspergillus flavus (A. flavus). Next, antifungal effects of single or mixed EOs on strain YQM were evaluated by the inhibition zone test. The cinnamon-litsea combined essential oil (CLCEO, Vcinnamon oil:Vlitsea oil = 3:5) displayed the best antifungal effect on strain YQM. The chemical composition of CLCEO was identified and quantified by gas chromatograph-mass spectrometry (GC-MS), and results revealed that the major components of CLCEO were cinnamaldehyde and citral. Finally, the effect of EOs on the microstructure of strain YQM mycelia was observed under scanning electron microscope (SEM). The mycelia exposed to cinnamon essential oil (CEO) and litsea essential oil (LEO) were partly deformed and collapsed, while the mycelia treated with CLCEO were seriously damaged and the deformation phenomena such as shrinking, shriveling and sinking occurred. Therefore, CLCEO has great potential for using as anti-mildew agents during peanut storage.
Four-Coordinate Monoboron Complexes with 8-Hydroxyquinolin-5-Sulfonate: Synthesis, Crystal Structures, Theoretical Studies, and Luminescence Properties

8-Hydroxyquinolin-5-sulfonic acid (8HQSA) was combined with 3-pyridineboronic acid (3PBA) or 4-pyridineboronic acid (4PBA) to give two zwitterionic monoboron complexes in crystalline form. The compounds were characterized by elemental analysis, single-crystal X-ray diffraction studies, and IR, 1H NMR, UV-Visible, and luminescence spectroscopy. The analyses revealed compounds with boron atoms adopting tetrahedral geometry. In the solid state, the molecular components are linked by charge-assisted (B)(O-H···−O(S) and N+-H···O(S) hydrogen bonds aside from C-H···O contacts and π···π interactions, as shown by Hirshfeld surface analyses and 2D fingerprint plots. The luminescence properties were characterized in terms of the emission behavior in solution and the solid state, showing emission in the bluish-green region in solution and large positive solvatofluorochromism, caused by intramolecular charge transfer. According to TD-DFT calculations at the M06-2X/6-31G(d) level of theory simulating an ethanol solvent environment, the emission properties are originated from π-π * and n-π * HOMO-LUMO transitions.
The Control of Metabolic CO2 in Public Transport as a Strategy to Reduce the Transmission of Respiratory Infectious Diseases

The global acceptance of the SARS-CoV-2 airborne transmission led to prevention measures based on quality control and air renewal. Among them, carbon dioxide (CO2) measurement has positioned itself as a cost-efficiency, reliable, and straightforward method to assess indoor air renewal indirectly. Through the control of CO2, it is possible to implement and validate the effectiveness of prevention measures to reduce the risk of contagion of respiratory diseases by aerosols. Thanks to the method scalability, CO2 measurement has become the gold standard for diagnosing air quality in shared spaces. Even though collective transport is considered one of the environments with the highest rate of COVID-19 propagation, little research has been done where the air inside vehicles is analyzed. This work explores the generation and accumulation of metabolic CO2 in a tramway (Zaragoza, Spain) operation. Importantly, we propose to use the indicator ppm/person as a basis for comparing environments under different conditions. Our study concludes with an experimental evaluation of the benefit of modifying some parameters of the Heating–Ventilation–Air conditioning (HVAC) system. The study of the particle retention efficiency of the implemented filters shows a poor air cleaning performance that, at present, can be counteracted by opening windows. Seeking a post-pandemic scenario, it will be crucial to seek strategies to improve air quality in public transport to prevent the transmission of infectious diseases.
Active Compounds in Zingiber officinale as Possible Redox Inhibitors of 5-Lipoxygenase Using an In Silico Approach

5-Lipoxygenase (5-LOX) converts arachidonic acid to lipidic inflammatory mediators such as leukotrienes (LTs). In diseases such as asthma, LTs contribute to a physiopathology that could be reverted by blocking 5-LOX. Natural products with anti-inflammatory potential such as ginger have been used as nutraceuticals since ancient times. 6-Gingerol and 6-shogaol are the most abundant compounds in the ginger rhizome; they possess anti-inflammatory, antioxidant, and chemopreventive properties. In the present study, 6-gingerol and 6-shogaol structures were analyzed and compared with two commercial 5-LOX inhibitors (zileuton and atreleuton) and with other inhibitor candidates (3f, NDGA, CP 209, caffeic acid, and caffeic acid phenethyl ester (CAPE)). The pharmacokinetics and toxicological properties of 6-gingerol, 6-shogaol, and the other compounds were evaluated. Targeted molecular coupling was performed to identify the optimal catalytic pocket for 5-LOX inhibition. The results showed that 6-gingerol and 6-shogaol follow all of the recommended pharmacokinetic parameters. These compounds could be inhibitors of 5-LOX because they present specific interactions with the residues involved in molecular inhibition. The current study demonstrated the potential of 6-gingerol and 6-shogaol as anti-inflammatory agents that inhibit 5-LOX, as they present a high level of performance in the toxicological analysis and could be catabolized by the cytochrome p450 enzymatic complex; however, 6-gingerol was superior in safety compared to 6-shogaol.
Histological Characterization of Some Feline Mammary Gland Tumors with Whole Slide Images Scan as a Trial of Remote Diagnosis

| Twelve feline mammary gland tissue samples were collected over a period of one year (Jan 2018-Jan 2019) from pets’ clinics in Cairo, Egypt. Aiming to identify the histologic patterns of feline mammary tumors and generation of whole slides scans for remote consultation. Each collected sample was accompanied by a complete animal data and case history. Samples were routinely processed and stained with hematoxylin and eosin (H&E) for histological examination, Masson’s trichrome (MTC) stain was used in some cases and immunohistochemical (IHC) staining using anti- CK8/18 and vimentin markers was performed as well. The tissue slides were scanned using a digital camera to obtain whole slide images (WSI) that were sent to three expert pathologists for teleconsulting. The histological criteria of each tumor type were carefully described under light microscope. Generally, all the examined cases showed marked histological heterogenicity. Ductal papillary or tubule-papillary carcinoma were the most common types of the examined cases. Also, few cases of cribriform and solid carcinomas were diagnosed. All carcinomas (11 cases) were CK8/18 positive. One case exhibited proliferation of pleomorphic myoepithelial cells that were positive for vimentin by IHC staining. Three rare cases of glycogen rich, mucinous and lipid rich carcinoma were recorded. Intense stromal reaction was observed within the examined cases. The trial of remote consulting of scanned slides, despite the presence of some described difficulties, revealed that the degree of accuracy in identifying the histological criteria ranged from 98 to 100% suggesting the positive impact of using whole slide images as a cheap alternative method for digital slide scanning.
EFFECTS OF SALINE-ALKALI MIXED STRESS ON THE GROWTH AND PHYSIOLOGICAL CHARACTERISTICS OF GIANT JUNCAO (PENNISETUM GIGANTEUM

In this paper, a pot experiment was conducted to simulate different degrees of saline-alkali stress to explore the response mechanism of Pennisetum giganteum Z. X. Lin to salt stress concerning its growth and physiological characteristics. The results showed that: (1) the growth of plant height decreased obviously with the increase of salt solution concentration; (2) with the increase of concentration, MDA content accumulated intermittently, P. giganteum reduced oxidative damage and maintained normal plant physiological metabolism through the complementary action of antioxidant enzymes SOD and CAT; (3) when the concentration of mixed salt solution was low, all osmotic regulatory substances accumulated slowly, and with the continuous increase of concentration, free proline content increased rapidly, which played a leading role in the process of plant osmotic regulation to ensure its physiological activities; (4) under mixed saline-alkali stress, the roots and stems of P. giganteum absorbed most of the Na, and transported K to the leaves at the same time.
4.0. Study on association of possible link of ions and insulin resistance in hypertension and diabetes

https://doi.org/10.30574/wjarr.2022. 14.2. 0443 Abstract To authenticate doubts relating to influence of altered state of some ions in insulin resistance and hypertension we analysed some biomolecules; glucose, insulin, glycated hemoglobin, magnesium, zinc, sodium, potassium and copper from diabetics, non-diabetics and hypertensives. Adopting spectroscopic and immunoassay methods values obtained were statistically evaluated by Anova (Analysis of variance). We observed identical pattern in glucose concentration, glycated hemoglobin and insulin levels among hypertensive and non-hypertensive subjects. However, an aggregated insulin response to glucose was elevated significantly (34.5+3.2 vs 20+2.3 µIU/mL, P<0.05). Zinc and magnesium levels were inversely correlated with HbAIc in insulin dependent diabetics and Non-insulin dependent diabetic (P<0.05). We observed Values increasing in tandem relationship with hypertension. We conclude that while hypertension and insulin resistance may have differential biochemical precursor, a nexus could be established for the place of ionic interferences in these
Realistic Mathematics Education in Traditional Community Culture

This study purposed to explore the values of indigenous culture in Cigugur traditional community related to Realistic Mathematics Education (RME) learning process. This study used qualita-tive method through ethnopedagogy approach to assess their cultural values. It is done by deep observation, documentation, in-depth interviews, and discussions of participants started from process that related to their daily life and to articulate the meaning of the tradition they have been doing. Af-ter conducting those steps, the author used triangulation to determine the data related to the study. The result of the study shows that the local wisdom of Cigugur traditional community is relevant to RME on agricultural system and traditional Seren Taun ceremony.
A comparative study on the functional outcome of intertrochanteric fractures treated by proximal femoral nailing or dynamic hip screw fixation

<p class="abstract"><strong>Background:</strong> Intertrochanteric fractures are one of the commonly occurring injuries in elderly patients and are high among females and those with osteoporosis. They were treated with either dynamic hip screw (DHS) fixation or proximal femoral nailing (PFNA2) here at our institution. The study was conducted in order to find which method of surgical fixation has better functional outcome. </p><p class="abstract"><strong>Methods:</strong> Total 96 patients of intertrochanteric fractures admitted during the study period of November 2017 to April 2019 were included for the study. These patients were randomly divided into two groups; DHS was used as implant in group1 and PFNA2 in group 2. Postoperatively patients were followed up after 1 month, 3months and 6 months of the surgery and were assessed using Harris hip score. <strong></strong></p><p class="abstract"><strong>Results:</strong> Harris hip score was higher with PFNA2 group compared to DHS group in all follow-ups. In unstable fractures DHS group had poor outcome compared to PFNA2. Radiological union occurred in 27.1 % cases by 3 months and 72.9% cases by 6 months with DHS whereas 70.8% and 97.9% respectively with PFNA2. </p><p class="abstract"><strong>Conclusions:</strong> PFNA2 gives a better functional outcome when compared to DHS. Even though DHS gives good functional outcome in stable fractures it is not so in the case of unstable fractures. The radiological union also is faster with proximal femoral nailing. Hence in our opinion PFNA2 can be the better fixation device compared to DHS especially in unstable fractures. </p>