Miracle-dz/UniFAR-FTUs huggingface dataset:
Fusaroxazin, a novel cytotoxic and antimicrobial xanthone derivative from Fusarium oxysporum

Abstract Oxazines and their derivatives are an uncommon natural heterocyclic compounds, which contain oxygen and nitrogen atoms and possess various bioactivities. A novel 1,4-oxazine-xanthone derivative, fusarioxazin (4) and three known sterols (1–3) were separated from Fusarium oxysporum EtOAc extract associated with Vicia faba L. (broad bean, Fabaceae) roots. Their structural assignment was accomplished using various spectroscopic tools and comparing with literature data. The cytotoxic and antimicrobial potentials of the novel metabolite (4) were evaluated. It possessed a significant antibacterial activity towards S. aureus (IZD 14.8 mm and MIC 5.3 µg/mL) and B. cereus (IZD 18.9 mm and MIC 3.7 µg/mL), in comparison to ciprofloxacin (IZDs 16.9 and 20.5 mm; MICs 3.9 and 2.3 µg/mL, respectively). Furthermore, it displayed a promising cytotoxic effect toward HCT-116 (IC50 2.1 µM), MCF-7 (IC50 1.8 µM), and A549 (IC50 3.2 µM) comparable to doxorubicin (IC50s 0.68, 0.54, and 0.39 µM, respectively). Graphical Abstract
Vibrational Stark Spectroscopy 3. Accurate Benchmark ab Initio and Density Functional Calculations for CO and CN

A new Stark-type experimental technique known as electroabsorption spectroscopy has been developed in S. G. Boxer's laboratories which offers the ability to measure the responses of isotropic solvated molecules to an applied electric field. It is applicable to a wide range of molecules and environments. We present benchmark ab initio and density-functional calculations employing 14 methods and double-ζ to penta-ζ augmented basis sets for the vibrational frequencies, dipole moment, polarizability, hyperpolarizability profiles, Stark shift, and other electroabsorption properties of two important (gas-phase) molecules, CO and CN-, for which a range of high-precision experimental data is available. The results show excellent agreement with these data, verify the earlier conclusion that the transition-moment polarizability rather than the polarizability change dominates the first-derivative response in the electroabsorption spectroscopy of these systems, and convergence with respect to the treatment of electro.
A comparison study: caregiver functioning and family resilience among families of children with cystic fibrosis, asthma, and healthy controls

ABSTRACT Caregivers of children with cystic fibrosis (CF) are at risk for psychosocial difficulties, which has been related to poorer child well-being and medical adherence. The present study utilized the National Survey of Children’s Health (NSCH) to examine self-reported differences in caregiver functioning among a matched sample of caregivers of youth with CF, asthma, and healthy controls (N = 114). CF caregivers reported poorer mental health and more parenting aggravation. Among CF caregivers, poorer caregiver mental health predicted less family resilience, which in turn, predicted more parenting aggravation. Findings have implications for prevention screening and brief interventions within pulmonary medicine.
BIODEGRADATION OF AROMATIC AND ALIPHATIC COMPOUNDS BY RHIZOBIAL SPECIES

The biodegradative capabilities of ten rhizobial species and four field isolates were evaluated in this study using growth studies, dense suspension cultures, and soil studies. After a preliminary screening, selected species were chosen for their degradative effect on aromatic, halogenated aromatic, and aliphatic substrates. The substrates utilized were: benzoate, phenol, 2-hydroxybenzoate, 3-hydroxybenzoate, 4-hydroxybenzoate, catechol, resorcinol, 2,3-dihydroxybenzoate, 2,4-dihydroxybenzoate, 2,6-dihydroxybenzoate, 3,4-dihydroxybenzoate, phenoxyacetate, 2,4-dichlorophenoxyacetate, cresols, mandelates, phthalate, 2-bromobenzoate, 2-chlorobenzoate, 4-chlorobenzoate, 2,4-dichlorobenzoate, 2-chlorophenoxyacetate, 4-chlorophenoxyacetate, 2-chlorophenol, 4-chlorophenol, 2,4-dichlorophenol, and hexadecane. Sinorhizobium xinjiangensis, Rhizobium leguminosarum, R. leguminosarum biovar trifolii, Bradyrhizobium japonicum, and strain V2 (field isolate) were able to metabolize a variety of organic compounds such as hydroxy- and dihydroxybenzoates, halogenated aromatic compounds, and alkanes. Significant differences were observed among the strains showing interspecies variability in their response to the different compounds. Dense cell suspension experiments conducted evaluating substrate loss, 4-chlorophenol, 4-chlorobenzoate, 4-chlorophenoxyacetate, cresols, resorcinol, and mandelate, among others, were metabolized although they did not support growth. Soil studies were performed showing that the addition of rhizobial inocula increased degradation of hexadecane in a soil environment.
Comparison of Five-Year Survival Rate Between Black and White Children With Acute Lymphoblastic Leukemia

Introduction Despite improvements in the prognosis of acute lymphoblastic leukemia (ALL), it is still the most common childhood cancer. The goal of this study was to investigate if there was a significant difference in the five-year survival between Black and White children with ALL, specifically up to the year 2016 which has not been researched. Methods A retrospective cohort study of Black and White children diagnosed with ALL between 1975 and 2016 was carried out using the Surveillance, Epidemiology, and End Results (SEER) Program database. Children aged 0-19 were separated into Black or White, and then survival analysis was used to compare five-year survival. A multivariate cox regression analysis was carried out to determine the association between race and five-year survival with ALL. Results Our sample included 17,663 cases consisting of 16,238 White children and 1,425 Black children. White children had a significantly increased five-year mortality survival when compared to Black children. Upon using multivariate cox regression analysis, both unadjusted and adjusted models showed a significantly higher risk of death in Black children when compared to White children. Conclusions Our study found that there is a significant difference in the five-year survival between Black and White children diagnosed with ALL. The difference in survival persists even when controlling for sex, age at diagnosis, year of diagnosis, and histology. Future studies should be carried out to control for more confounders that the SEER database is unable to control for.
Wave climate in subarctic seas from Voluntary Observing Ships: 1900--2020

Wave climate in the North Atlantic and subarctic seas is investigated based on data from Voluntary Observing Ships for the period 1900–2020. The proposed approach differs from any previous studies of the given region as a detailed climatology and long-term trends were performed separately for wind sea and swell characteristics. The method allows for tracing Arctic climate tendencies of the last century and analyzing the reasons behind the observed changes taking place.
The promise of flexicurity: Can employment and income security mitigate the negative effects of job insecurity?

Flexicurity is an integral part of the EU Employment Strategy. Flexicurity promises that it is possible to simultaneously provide organisations with greater flexibility and offer workers the necessary level of security. This is achieved by replacing job security, which stems from a permanent employment contract, with employment and income security. The aim of this article is to present an individual-level investigation of the relationships between various elements of flexicurity, examining how they affect psychological well-being and job satisfaction. A heterogeneous sample of 432 adults employed under various types of employment arrangements participated in the study. The results showed that the type of employment arrangement was the main predictor of perceived job insecurity. Moreover, perceived job insecurity mediated the relationship between employment arrangement and psychological outcomes. Finally, employment and income security failed to mitigate the negative effect of job insecurity. The promise of flexicurity is therefore called into question.
Comparison of Performance of the Pediatric Index of Mortality (PIM)-2 and PIM-3 Scores in the Pediatric Intensive Care Unit of a High Complexity Institution

Abstract Objective To determine the performance of each of the available pediatric index of mortality (PIM) scores, by assessing the capability for discrimination and calibration in patients admitted to a pediatric intensive care unit in Bogotá. Design and setting We designed a retrospective, observational cohort study, which included all patients aged between a month and 17 years and 364 days, admitted to the pediatric intensive care unit of a high complexity university hospital between April 1, 2016 and December 31, 2018. We analyzed the standardized mortality ratio, discrimination, calibration, and net reclassification index (NRI) for each model. Results A total of 722 patients were included, the mortality rate was 3.74%, and for PIM-3, the ratio between expected and observed mortality was 0.66 [confidence interval (CI) 0.40–1.05] for PIM-2 and 1.00 (CI 0.59–1.68) for PIM-3. The Hosmer–Lemeshow (HL) test suggests inadequate calibration for PIM-2 (HL = 13.18, p = 0.11) and adequate calibration for PIM-3 (HL = 28.08, p < 0.01). The area under the diagnostic performance curves for PIM-2 and PIM-3 were 0.87 (95% CI 0.80–0.94) and 0.89 (95% CI 0.82–0.95), respectively. The NRI was −27.1%. PIM-3 classified survivors better than PIM-2, but inadequately classified nonsurvivors. Conclusion Although both models show adequate discrimination ability, PIM-3 shows a better correlation between predicted risk score and observed mortality. Thus, it may be a useful tool for measuring the internal processes of intensive care units in Colombia and for making comparisons between groups of similar characteristics. How to cite this article Quiñónez-López D, Patino-Hernandez D, Zuluaga CA, García ÁA, Muñoz-Velandia OM. Comparison of Performance of the Pediatric Index of Mortality (PIM)-2 and PIM-3 Scores in the Pediatric Intensive Care Unit of a High Complexity Institution. Indian J Crit Care Med 2020;24(11):1095–1102.
Plasma-Based Dry Reforming: A Computational Study Ranging from the Nanoseconds to Seconds Time Scale

We present a computational study for the conversion of CH4 and CO2 into value-added chemicals, i.e., the so-called “dry reforming of methane”, in a dielectric barrier discharge reactor. A zero-dimensional chemical kinetics model is applied to study the plasma chemistry in a 1:1 CH4/CO2 mixture. The calculations are first performed for one microdischarge pulse and its afterglow, to study in detail the chemical pathways of the conversion. Subsequently, long time-scale simulations are carried out, corresponding to real residence times in the plasma, assuming a large number of consecutive microdischarge pulses, to mimic the conditions of the filamentary discharge regime in a dielectric barrier discharge (DBD) reactor. The conversion of CH4 and CO2 as well as the selectivity of the formed products and the energy cost and energy efficiency of the process are calculated and compared to experiments for a range of different powers and gas flows, and reasonable agreement is reached.
Analytical Performance of the Exacto Test HIV Self-Test: A Cross-Sectional Field Study in the Democratic Republic of the Congo

Abstract The Democratic Republic of the Congo (DRC) has begun implementing HIV self-testing to boost the first “95” of the UNAIDS 95-95-95 targets by 2025. This study aims to assess the performance and usability of the Exacto Test HIV (Biosynex, Strasbourg, France) self-test in the lab and in the field. The Exacto Test HIV self-test demonstrated high virological performance (sensitivity, 99.6%; specificity, 100%) in the lab and in the field in the hand of untrained users (sensitivity, 100%; specificity, 98.9%). Taken together, the excellent performance and usability characteristics of the Exacto Test HIV (Biosynex) self-test make the kit a viable option for HIV self-testing in the DRC.
A New Approach to Set the Absolute Midsagittal Plane of the Mandible Using a Similarity Index in Skeletal Class III Patients with Facial Asymmetry

This study sought to test the feasibility of a newly developed plane called computed modified absolute mandibular midsagittal plane (cmAMP) based on the similarity index (SI) for evaluating the stereoscopical symmetry of the mandible by comparison with other proposed midsagittal planes. This study involved 29 adult patients (15 men, 14 women; average age, 23.1 ± 6.9 years) with skeletal Class III facial asymmetry who underwent bimaxillary orthognathic surgery. Using cone-beam computed tomography images taken before and 1 year after surgery, cmAMP with the highest SI value between the two anterior segments of the hemi-mandible was set by a computer algorithm. Results show that the SI using cmAMP had the highest value (0.83 ± 0.04) before surgery compared to the other midsagittal planes, and was not significantly different from the SI (0.80 ± 0.05) using a facial midsagittal plane (MSP) after surgery. The distance (1.15 ± 0.74 mm) and angle (2.02 ± 0.82◦) between MSP and cmAMP after surgery were significantly smaller than those between MSP and other midsagittal planes. In conclusion, the cmAMP plane best matches the two anterior segments of hemi-mandible symmetrically and is the closest to MSP after orthognathic surgery in skeletal Class III patients with facial asymmetry.
PENGARUH PENAMBAHAN KARAGENAN EUCHEUMA COTTONII TERHADAP KARAKTERISTIK EKADO IKAN NILA

Penelitian ini bertujuan untuk mendapatkan pengaruh penambahan jumlah karagenan Eucheuma cottoni dalam pengolahan ekado ikan nila. Penelitian ini dilakukan menggunakan metode rancangan acak lengkap dengan perlakuan 0%, 2,5%, 5%, 7,5%, 10%. Analisis data menggunakan Anova. Kualitas ekado ditentukan berdasarkan hedonik dan kualitas kimianya . Hasil penelitian menunjukkan bahwa penambahan karagenan Eucheuma cottonii berpengaruh signifikan terhadap nilai hedonik dengan parameter kenampakan tekstur , dan kualitas kimia dengan parameter kadar air, kadar abu, dan kadar protein, sedangkan dalam rasa, bau, penampilan dan kadar lemak tidak berpengaruh signifikan . Hasil terbaik untuk ekado dengan penambahan karagenan Eucheuma cottonii sebesar 5%, dengan nilai kenampakan 7,6 , rasa 6,26 , bau 6,95 , tekstur 7,86 , dan nilai kimia kadar air 66 , 98 %, kadar abu 4,165 % , kadar protein 15,2 %, kadar lemak 2,05 %. P enambahan karagenan Eucheuma cottoni sebagai bahan tambahan pangan pada ekado dapat meningkatkan tekstur ekado .
Crystal structure and vibrational analysis of novel nonlinear optical L‐histidinium tetrafluoroborate (L‐HFB) single crystals

Single crystals of L‐histidinium tetrafluoroborate (L‐HFB) were grown by slow evaporation of an aqueous solution at room temperature. The crystal structure has been elucidated through single crystal X‐ray crystallography. The infrared (IR) and Raman spectroscopic measurements fully confirm the X‐ray crystal structure. The potential role of hydrogen bonds of the title crystal and its influence on interaction between the L‐histidinium cation and tetrafluoroborate anion has been discussed in detail. The crystal is a very good second harmonic generator. Its powder SHG efficiency is calculated as deff = 1.70 deff (KDP). (© 2007 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Evolving thermal thresholds explain the distribution of temperature sex reversal in an Australian dragon lizard

Species with temperature‐dependent sex determination (TSD) are particularly vulnerable to climate change because a resultant skew in population sex ratio can have severe demographic consequences and increase vulnerability to local extinction. The Australian central bearded dragon (Pogona vitticeps) has a thermosensitive ZZ male/ZW female system of genetic sex determination (GSD). High incubation temperatures cause reversal of the ZZ genotype to a viable female phenotype. Nest temperatures in the wild are predicted to vary on a scale likely to produce heterogeneity in the occurrence of sex reversal, and so we predict that sex reversal will correlate positively with inferred incubation conditions.
PSIX-5 Fetal programming in an industry applied setting – Effects of feeding methionine during late gestation on progeny performance, feed efficiency, and carcass quality for feedlot steers

The objective of this study was to assess if rumen-protected methionine supplementation during gestation would impact male offspring performance and carcass quality in an applied setting. Sixty-seven gestating cows were randomly assigned to control (CON), or methionine (MET) treatments. Cows had ad libitum access to hay from a round bale feeder and were fed once daily in a bunk for approximately eight weeks prior to calving either: 0.75 kg/head/d of supplement pellet supplying 12 g rumen-protected MET/cow/d, or identical pellet with no added MET. The 34 steer progeny (MET n = 18; CON n = 16) were transported to a feedlot, assigned to one of seven pens by weight and fed a corn-based grower diet (58% corn silage, 26% alfalfa haylage, 15% soybean meal) for 47 days, followed by a finisher diet (78% high moisture corn, 12% alfalfa haylage, 8% soybean meal) for 115±31.5 days until slaughter. Body weights were recorded biweekly. Organ weights were recorded at slaughter. Carcass quality, meat quality, and rib composition were recorded 24 to 48 hours after slaughter. Data were analyzed using PROC GLIMMIX in SAS, with treatment as the fixed effect, and pen as the random effect. Supplementation of MET during pregnancy increased weaning weight (MET: 311, CON: 291 ±14.8 kg; P ≤ 0.001), final weight (ME: 668, CON: 631 ±16.8 kg; P = 0.01), and individual dry matter intake (MET: 13, CON: 12 ±0.5 kg/d; P = 0.04) during the finishing phase. There was no effect of maternal methionine supplementation (P ≥ 0.05) for average daily gain. Hot carcass weight was greater for MET steers (MET 372 vs. CON 353 ±9.5 kg; P = 0.03), while organ weights and carcass quality were not affected (P ≥ 0.05) by MET supplementation. This study showed that supplementing methionine during late gestation in an industry applied setting improved some offspring performance measures but did not result in enhanced carcass quality.
Bankruptcy Prediction: A Model Based on Cash Flow Ratios: Evidence From Selected European Countries

The importance of assessing the financial distress risk of a company is a topic that has been of central value in many different economic fields and since a long time. Until the twenty-first century, most of the studies were concentrated primarily on using mathematical and statistical methods to assess the health of businesses. Many of these studies employed either accounting-based ratios or cash flow-based ratios; even if there is not a unique conclusion, the use of cash flows seems to improve the predictive capacity of the models significantly. Especially in the last twenty-five years, methods derived from different fields started to be applied in forecasting corporate failures, such as artificial neural networks, genetic algorithms, and fuzzy logic.The objective of this study was to test the goodness of the discriminatory power of ratios based only on cash flows using a model that employs genetic algorithms and fuzzy logic. Five countries (Germany, Spain, France, Great Britain, Italy) and five Nace macro sectors (Agriculture, Industry, Services, Construction, Commerce and Food) have been considered in the analysis for a total of around 719-thousand companies. The model has proven to be well-performing on most of the countries and sectors that have been tested. The results obtained are almost all adequate; in particular, in Germany and Spain, results have been particularly good.The main weaknesses of this work are the limited availability of financial data in some countries and the time delay from the reporting of financial statement to the availability of the data through web services. It means that a large-scale risk assessment requires – being useful for the public and the private sectors – greater and faster disclosure of information at European level, and standardization of financial information transparency among countries.
TVET Students’ Attitudes and Motivation toward Learning English

The English language plays a vital appearance worldwide, especially in educational institutions, regardless of any levels. Besides, many educational institutions have implemented the English language as an influential feature of interaction for teachers and students, mainly teaching and learning. Thus, this study is to examine students’ attitudes and motivation in English language learning. The research design employed in this study is a survey and instrument adapted from Gardner’s (1985), the Attitude and Motivation Test Battery (AMTB). The questionnaire distributed to 37 male and 23 female students. According to the findings, students with a positive attitude possess a high motivation to be conversant in English. Perhaps students with positive attitudes and high motivation could enact Band 3 in the Malaysian University English Test (MUET) and above.
Supporting students’ engagement with teachers’ feedback: the role of students’ school identification

Abstract This study explored the link between teachers’ feedback and students’ behavioural engagement with school identification. Using a sample of 2534 students from 6th to 12th school year, we examined whether their perceptions about teachers’ feedback were related to their behavioural engagement and mediated by their school identification. We also explore whether this relation was moderated by students’ year of schooling and by the type of secondary course they were enrolled and the differences of latent means between these groups. Results confirmed the expected mediation: teachers’ feedback was associated with an increased behavioural engagement via increased school identification. Only the type of students’ secondary course moderated this relation. Students in the 12th year perceived that their teacher used less effective feedback and felt lower school identification than students in the early years of schooling. These finding illustrated the underlying mechanism through which teachers’ feedback affect students’ behavioural engagement with school.
It’s not all about the COLREGs: a case-based risk study for autonomous coastal ferries

Whilst the maritime world is preparing for autonomous vessels or Maritime Autonomous Surface Ships (MASS), as defined by IMO, we suggest an approach to investigate the risks involved with introducing such ships into service. This case study investigates the risks regarding other surface vessels that the MASS can encounter on their voyage between two berths used by coastal ferries in Norway. The ferries in this case, operate within a fjord declared as testbed for autonomous operations. Albeit the technology is available and declared ready, the area of operation is not. This paper seeks to address some of the remaining obstacles with regards to the risks involved.
A cross sectional study on musculoskeletal discomfort and its determinants among agricultural workers in a rural community of Tamil Nadu

Musculoskeletal disorders are one of the major contributors of disability worldwide. Low back pain is one of the leading causes of disability globally. At least one out of every five persons live with Musculoskeletal disorders. They are injuries or disorders of the muscles, nerves, tendons, joints, cartilage and other supporting structures of the upper and lower limbs, neck, and lower back caused by sudden exertion or prolonged exposure to physical factors such as repetition, force, vibration, or awkward posture. It generally refers to soft tissue injuries occurring gradually over time. It is especially common in rural areas where people are more commonly involved in strenuous physical activities. They significantly limit the mobility and agility of an individual, ultimately leading to reduced productivity by causing early fatigue and retirement. They also affect the ability to participate in ABSTRACT