Miracle-dz/UniFAR-FTUs huggingface dataset:
Demographic Factors Predict Risk of Lymph Node Involvement in Patients with Endometrial Adenocarcinoma

Simple Summary The presence of lymph node involvement for patients with endometrial cancer guides treatment after surgery. Demographic factors in addition to pathologic tumor characteristics may more accurately predict the risk of lymph node involvement in this population. This study utilized a publicly available database of endometrial cancer patients diagnosed between 2004 and 2016. Pathologic primary tumor predictors of lymph node involvement were identified using statistical analysis. Among the 35,170 patients included, 2864 were node positive. Analysis revealed that younger patient age, black versus white race, increasing primary tumor stage and biologic aggressiveness, and tumor size were predictive of lymph node involvement. Both black versus white and other versus white race strongly predicted paraaortic lymph node involvement. Independent subset analyses of black and white women revealed that tumor grade was a stronger predictor of lymph node involvement among black women. In addition to standard pathologic tumor features, patient age and race are associated with a higher risk of regional lymph node involvement. This information may inform adjuvant treatment decisions and guide future studies. Abstract The presence of lymph node positivity (LN+) guides adjuvant treatment for endometrial adenocarcinoma (EAC) patients, but recommendations regarding LN evaluation at the time of primary surgery remain variable. Sociodemographic factors in addition to pathologic tumor characteristics may more accurately predict risk of LN+ in EAC patients. Patients diagnosed between 2004 and 2016 with pathologic T1-T2 EAC who had at least one lymph node sampled at the time of surgery in the National Cancer Data Base were included. Pathologic primary tumor predictors of LN+ were identified using logistic regression. To predict overall, pelvic only, and paraaortic and/or pelvic LN+, nomograms were generated. Among the 35,170 EAC patients included, 2864 were node positive. Using multivariable analysis, younger patient age (OR 0.98, 95% CI 0.98–0.99, p < 0.001), black versus white race (OR 1.19, 95% CI 1.01–1.40, p = 0.04), increasing pathologic tumor stage and grade, increase in tumor size, and presence of lymphovascular invasion were predictive of regional LN+. Both black versus white (OR 1.64, 95% CI 1.27–2.09, p < 0.001) and other versus white race (OR 1.54, 95% CI 1.12–2.07, p = 0.006) strongly predicted paraaortic LN+ in the multivariable analysis. Independent subset analyses of black and white women revealed that tumor grade was a stronger predictor of LN+ among black women. In addition to standard pathologic tumor features, patient age and race were associated with a higher risk of regional LN+ generally and paraaortic LN+ specifically. This information may inform adjuvant treatment decisions and guide future studies.
Microwave-Assisted, Ionic Liquid-Catalyzed Synthesis of 1,2-Disubstituted Benzimidazoles under Solvent-Free Conditions

An efficient method for the synthesis of 1,2-disubstituted benzimidazoles has been developed from 1,2‐diaminobenzenes and aldehydes using 1-butyl-3-methylimidazolium ([Bmim]BF4) as a catalyst under solvent-free conditions. Various products were obtained in good to excellent yields under microwave irradiation. The synthesis features some advantages such as short reaction time, environmentally benign conditions, simple work-up procedure, and high efficiency.
Pragmatic Peacekeeping in a Multipolar Era: Liberal Norms, Practices, and the Future of UN Peace Operations

ABSTRACT As UN peacekeeping continues to move through a period of change and rupture, we conceptualise this turn as ‘pragmatic’ and take interest in its normative dimensions. In this introduction to a Special Issue, we take stock of scholarship on this pragmatic turn, arguing that it can be enriched through deeper engagement with theories of norms and practices, drawing especially on pragmatist approaches in the field of International Relations. We also argue that, while pragmatic peacekeeping may be less ideologically ambitious than earlier iterations of the practice, it still has a strong normative dimension.
RESISTANCE OF WOOD PLASTIC COMPOSITE PRODUCED BY EXTRUSION AND COMPRESSION AGAINST THE FUNGI XYLOPHAGES POSTIA PLACENTA AND TRAMETES VERSICOLOR.

Wood plastic composite constitute compounds of great demand like materials. Biological agents are one of the main causes of the deterioration of wood and its derivatives. Creating materials more resistant to these agents is an important task for the forestry industry.The objective of this research was to evaluate the resistance of wood plastic composite to the fungi xylophages Postia placenta and Trametesversicolor . The boards were obtained by means of two treatments (1-extrusion and 2-compression), was used Pinuscaribaea wood, thermoplastic polyethylene terephthalate, and calcium carbonate in Studies conducted by Fenget al. (2014) the resistance to fungi and water absorption of wood plastic composite (WPC), made from wood / HDPE and bamboo / HDPE with different fiber content as a test material. The results show that the resistance to fungi varied with the fiber content. The compounds with higher fiber content were more susceptible to fungi showing clear evidence of fungal growth and colonization in the WPC sample. The water absorption of WPC was jointly affected by the increased content of wood or bamboo, which progressed rapidly, as well as the growth of fungi, was also promoted with the water absorption of WPC. The studies carried out in this investigation were stable since the wood content was the same for the two treatments, this demonstrates the search of adequate formulations that adjust to humidity conditions and improve the resistance to biological agents
"Big Crunch" Optimization Method

In this article we present the Big Crunch Optimization Method (BCOM), a global optimization method developed by us upon the analogy of a cosmological theory known as Closed Universe. According to this, if the gravitational energy is greater than the energy generated by the Big Bang (kinetic energy) the expansion of the universe will stop, being followed by a contraction, which will reduce the universe to a single point with both infinite density and temperature (Big Crunch). Similarly, the optimization method starts from an initial population, which is being reduced due to the attraction of bodies (solutions) by other ones with greater mass (aptitude). The process is finished when just one body lies in the search space (which corresponds to the optimal solution). Therefore, the Big Crunch Optimization Method, among its particularities, works with a population of variable size, unlike usual procedures, which consider a single solution or a population with fixed size. In the following item of this paper the main theories related to the future of the universe are briefly described, making in the sequence the analogy between the Closed Universe Theory and our method of optimization. Aiming to illustrate the applicability of the proposed method to the structural optimization, the weight minimization of a plane truss with ten bars was carried, which consists of a classical example. This structure was analyzed considering the sections of elements as continuous variables. The obtained results are compared to the ones
Profil Kemandirian dan Kreativitas Siswa SMA Sedes Sapientiae Semarang pada Pembelajaran Konsep Bioteknologi

This study aims to analyze the profile of students' independence and creativity in learning biotechnology materials. This research is a descriptive qualitative research type with the research subject being 60 students of class XII MIPA Sedes Sapientiae Semarang in the academic year 2021 – 2022. The technique of collecting data is using a questionnaire about students' independence and creativity. The results showed that the students of class XII MIPA SMA Sedes Sapientiae Semarang had an independent and creative attitude in carrying out biotechnology projects to show a percentage of over 60% overall. Of course, the level of independence and creativity between one student and another varies. Many students tend to be less independent and innovative but also less dependent on others and lacking ideas. It can be seen from the research results that the figures range at most at 50-60%. Project-based learning model innovation using a scientific approach can be used to increase students' independence and creativity in learning.
Brand Affiliation and Property Size Effects on Measures of Performance in Lodging Properties

Performance measures, such as occupancy percentage and average daily rate, are critical statistics utilized by business strategists across the lodging industry. Approximately one-third of the population in a state-wide sample of lodging properties was utilized in an analysis of selected factors affecting operating performance. Polynomial and interactive regression were incorporated in separate analyses, wherein researchers evaluated main and interactive effects of property size and brand affiliation on occupancy and average daily rate. Independent properties were found to have significantly higher average daily rates than brand-affiliated properties regardless of their size. The interaction effect of brand affiliation and property size was marginally significant on the dependent variable occupancy. Sensitivity analyses of the results were performed on a reduced set of properties, using revenue per available room as a surrogate for performance.
Reducibility of the Hilbert Scheme of Smooth Curves and Families of Double Covers

Let $\mathcal{I}_{d,g,r}$ be the union of irreducible components of the Hilbert scheme whose general points represent smooth irreducible complex curves of degree $d$ and genus $g$ in $\mathbb{P}^r$. Severi claimed in [15] that $\mathcal{I}_{d,g,r}$ is irreducible if $d \geq g+r$. His statement turned out to be correct for $r = 3$ and $4$, while for $r \geq 6$, counterexamples have been found by using families of $m$-sheeted covers of rational curves with $m \geq 3$. In this work we show the existence of an additional component of $\mathcal{I}_{d,g,r}$ whose general elements are double covers of curves of positive genus. In addition, we find upper bounds for the dimension of the possible components of $\mathcal{I}_{d,g,r}$.
High and low thermal conductivity of amorphous macromolecules

We measure the thermal conductivity, heat capacity and sound velocity of thin films of five polymers, nine polymer salts and four caged molecules to advance the fundamental understanding of the lower and upper limits to heat conduction in amorphous macromolecules. The thermal conductivities vary by more than one order of magnitude, from 0.06 W m -1 K -1 for [6,6]-phenyl-C71-butyric acid methyl ester (PC71BM) to 0.67 W m -1 K -1 for poly(vinylphosphonic acid calcium salt) (PVPCa). Minimum thermal conductivity calculated from the measured sound velocity and effective atomic density is in good agreement with the thermal conductivity of macromolecules with various molecular structures and intermolecular bonding strength.
Turbulent boundary layers absent mean shear

We perform an experimental study to investigate the turbulent boundary layer above a stationary solid glass bed in the absence of mean shear. High Reynolds number $(Re_{\unicode[STIX]{x1D706}}\sim 300)$ horizontally homogeneous isotropic turbulence is generated via randomly actuated synthetic jet arrays (RASJA – Variano & Cowen J. Fluid Mech. vol. 604, 2008, pp. 1–32). Each of the arrays is controlled by a spatio-temporally varying algorithm, which in turn minimizes the formation of secondary mean flows. One array consists of an $8\times 8$ grid of jets, while the other is a $16\times 16$ array. Particle image velocimetry measurements are used to study the isotropic turbulent region and the boundary layer formed beneath as the turbulence encounters a stationary wall. The flow is characterized with statistical metrics including the mean flow and turbulent velocities, turbulent kinetic energy, integral scales and the turbulent kinetic energy transport equation, which includes the energy dissipation rate, production and turbulent transport. The empirical constant in the Tennekes (J. Fluid Mech. vol. 67, 1975, pp. 561–567) model of Eulerian frequency spectra is calculated based on the dissipation results and temporal frequency spectra from acoustic Doppler velocimetry measurements. We compare our results to prior literature that addresses mean shear free turbulent boundary layer characterizations via grid-stirred tank experiments, moving-bed experiments, rapid-distortion theory and direct numerical simulations in a forced turbulent box. By varying the operational parameters of the randomly actuated synthetic jet array, we also find that we are able to control the turbulence levels, including integral length scales and dissipation rates, by changing the mean on-times in the jet algorithm.
Dengue, Chikungunya, and Zika: The Causes and Threats of Emerging and Re-emerging Arboviral Diseases

The recent emergence and re-emergence of viral infections transmitted by vectors, Zika, chikungunya, dengue, and others, is a cause for international concern. Here, we provide a summary of the current understanding of the transmission, clinical features, diagnosis, global burden, and the likelihood of future epidemics by these viruses. Arboviruses transmitted by mosquitoes are challenging to diagnose and can have surprising clinical complications. Dengue, chikungunya, and Zika are the most important diseases caused by arboviruses worldwide, especially in tropical and subtropical regions. These are transmitted to humans by day-biting Aedes aegypti and Aedes albopictus mosquitoes. In India, the increase in the incidence of dengue and chikungunya cases is primarily linked to the dissemination of Aedes aegypti. A rapid and accurate diagnosis is paramount for effectively controlling dengue outbreaks. As there is no vaccination or specific treatment available for these viruses, vector control is the only comprehensive solution available.
Relative global dimensions of extensions

ABSTRACT An extension of algebras is a homomorphism of algebras preserving identities. Given an extension f:B→A, the relative global dimension of f is defined to be the supremum of relative projective dimensions of all A-modules. In this paper, we compare relative homological dimensions of two extensions of ordinary algebras under certain conditions. As an application, for any natural number n, we present a general method for constructing non-trivial extensions of Artin algebras of relative global dimension at least n.
Evaluation of Water Quality Index Using Various Physico-Chemical Parameters and Correlation Analysis of Gothivali Waterbody, Navi-Mumbai, Maharashtra, India

: Water is a necessary component for the survival of all humans and animals, a finite resource in the natural world. Water quality is crucial not only for humans, but also for the plants and animals that rely on it to survive. As a result, water quality must be checked at regular intervals. This study focuses on determining the quality of water of Gothivali Waterbody, Navi-Mumbai using the Weighted Arithmetic Water Quality Index (WQI) and several physico-chemical factors i.e
A Case Study on Power Outage Impacts from Future Hurricane Sandy Scenarios

AbstractHurricane Sandy (2012, referred to as Current Sandy) was among the most devastating storms to impact Connecticut’s overhead electric distribution network, resulting in over 15 000 outage locations that affected more than 500 000 customers. In this paper, the severity of tree-caused outages in Connecticut is estimated under future-climate Hurricane Sandy simulations, each exhibiting strengthened winds and heavier rain accumulation over the study area from large-scale thermodynamic changes in the atmosphere and track changes in the year ~2100 (referred to as Future Sandy). Three machine-learning models used five weather simulations and the ensemble mean of Current and Future Sandy, along with land-use and overhead utility infrastructure data, to predict the severity and spatial distribution of outages across the Eversource Energy service territory in Connecticut. To assess the influence of increased precipitation from Future Sandy, two approaches were compared: an outage model fit with a full set of.
Observer-based dynamic local piecewise control of a linear parabolic PDE using non-collocated local piecewise observation

This paper employs the observer-based output feedback control technique to study the problem of local piecewise control for a linear parabolic partial differential equation(PDE) using non-collocated local piecewise observation. By the noncollocated local piecewise observation, a Luenberger-type PDE observer is first constructed to exponentially track the state of the PDE in the sense of both ℒ 2 norm and ℋ 1 norm. Based on the estimated state, a collocated local piecewise state feedback controller is then proposed for exponential stabilisation of the PDE. Sufficient conditions on exponential stabilisation of the PDE by the suggested feedback controller in the sense of both ℒ 2 norm and ℋ 1 norm are developed by utilising Lyapunov direct method, integration by parts, Wirtinger's inequality, and first mean value theorem for definite integrals, and presented in terms of standard linear matrix inequalities. The well-posedness is also analysed for both open-loop and resulting closed-loop PDE by using C 0 -semigroup approach. Finally, numerical simulation results are presented to show the effectiveness of the proposed design method.
To Be Involved or Not to Be Involved: Testing Prison Staff Job Involvement Using the Job Demands–Job Resources Model

In this study, data were used from 322 employees at a large medium- and maximum-security prison in the Southern United States to examine the influence of job demands (dangerousness of the job, role overload, role ambiguity) and job resources (employee input into decision-making, instrumental communication, job variety) on employee job involvement. We also controlled for demographic characteristics (gender, age, position, tenure, and educational attainment). Drawing on the job demands–job resources model, four separate equations were estimated to assess the influence of job demands and job resources both separately and jointly. Overall, job resources (specifically, employee input into decision-making and job variety) have a stronger influence on job involvement than do job demands. The findings indicate that to boost employee job involvement in correctional settings, employers must implement policies and practices that facilitate the sharing of job resources in the work environment. Implications for policy and future research are also discussed.
Next-Generation Auditory Steady-State Responses in Normal-Hearing Adults: A Pilot Test–Retest Reliability Study

The Auditory Steady-State Response (ASSR) provides objective and ear-specific information essential for early and appropriate intervention. Test–retest reliability is essential for audiological monitoring. The test–retest reliability of the ASSR has received limited attention. Only a handful of studies found in the literature investigated the test–retest reliability of old-generation ASSR using amplitude or mixed modulated stimuli. However, to our knowledge, no published reports have specifically examined the test–retest reliability of the next-generation ASSR using Chirp family stimuli as implemented in the Interacoustics Eclipse system. This pilot study investigated (a) the test–retest reliability of air conduction (AC) ASSR thresholds across two test sessions and (b) the relationship between differences in ASSR thresholds across two sessions to the residual noise levels in normal-hearing adults. Methods: Fifteen normal-hearing adults (12 females) (30 ears) with an average age of 28 years were recruited for the study. The ASSRs were recorded using a two-channel recording montage. The automatic default stimuli and recording protocol using 90 Hz ASSR, and the accuracy method (p < 0.01) as implemented in the Eclipse system is used to measure ASSR. Results: The study demonstrated strong test–retest reliability for ASSR across frequencies (500 Hz, 1000 Hz, 2000 Hz, and 4000 Hz). Notably, the highest reliability was observed at 500 Hz. The mean test–retest reliability of ASSR was found to be comparable to pure-tone thresholds, but the intra-subject variability is higher for ASSR compared to pure-tone thresholds. Additionally, no significant correlation was found between the difference in ASSR residual noise levels at the threshold and the difference in ASSR thresholds at all tested frequencies. Conclusion: The next-generation system demonstrated strong test–retest reliability across the frequencies examined in this pilot study. Particularly, an improvement in reliability was observed at 500 Hz compared to the old-generation ASSR. This enhancement can be attributed to the utilization of narrow-band CE-chirp stimuli, which generate large amplitude responses, and the implementation of an improved detection paradigm involving multiple harmonics spectral and phase analysis. This pilot study only enrolled adults with normal hearing, and future investigations should include a larger sample size comprising both normal-hearing and hearing-impaired individuals, as well as the pediatric population.
Exploring the Antimicrobial, Anticancer, and Apoptosis Inducing Ability of Biofabricated Silver Nanoparticles Using Lagerstroemia speciosa Flower Buds against the Human Osteosarcoma (MG-63) Cell Line via Flow Cytometry

Biosynthesized nano-composites, such as silver nanoparticles (AgNPs), can be engineered to function as smart nano-biomedicine platforms for the detection and management of diverse ailments, such as infectious diseases and cancer. This study determined the eco-friendly fabrication of silver nanoparticles using Lagerstroemia speciosa (L.) Pers. flower buds and their efficacy against antimicrobial and anticancer activities. The UV-Visible spectrum was found at 413 nm showing a typical resonance spectrum for L. speciosa flower bud extract-assisted silver nanoparticles (Ls-AgNPs). Fourier transform infrared analysis revealed the presence of amines, halides, and halogen compounds, which were involved in the reduction and capping agent of AgNP formation. X-ray diffraction analysis revealed the face-centered cubic crystals of NPs. Energy dispersive X-ray verified the weight of 39.80% of silver (Ag), TEM analysis revealed the particles were spherical with a 10.27 to 62.5 nm range, and dynamic light scattering recorded the average particle size around 58.5 nm. Zeta potential showed a significant value at −39.4 mV, and finally, thermo-gravimetric analysis reported higher thermal stability of Ls-AgNPs. Further, the obtained Ls-AgNPs displayed good antimicrobial activity against clinical pathogens. In addition, a dose-dependent decrease in the anticancer activity by MTT assay on the osteosarcoma (MG-63) cell line showed a decrease in the cell viability with increasing in the concentration of Ls-AgNPs with an IC50 value of 37.57 µg/mL. Subsequently, an apoptotic/necrosis study was conducted with the help of Annexin-V/PI assay, and the results indicated a significant rise in early and late apoptosis cell populations. Therefore, green synthesized Ls-AgNPs were found to have potent antimicrobial and anticancer properties making them fascinating choices for future bio-medical implementations.