Miracle-dz/UniFAR-FTUs huggingface dataset:
Different classes of antibiotics have varying effects on the risk of developing opioid use disorder: a national database study

ABSTRACT Objective To examine whether different classes of antibiotics in combination with opioids differentially effect the risk of developing opioid use disorder (OUD). Methods A cohort study was conducted to identify adult subjects (18–65 years old) with no previous history of OUD. Two cohorts were defined: subjects who were prescribed an opioid or an opioid in combination with antibiotics in the emergency department or inpatient unit, from the years 2015 to 2018. The diagnosis of an Opioid Related Disorder (F11.10-F11.20) 12 months following discharge from the emergency department or inpatient unit was then observed within the cohorts following the index event as identified by the ICD-10 procedural coding system. Results Primary analysis showed that penicillin G had no statistically significant effect, while the following list of antibiotics were associated with increased risk of developing OUD in order from highest to lowest risk: cefepime > tazobactam > ertapenem > doxycycline > ceftriaxone, sulfamethoxazole > clindamycin > azithromycin > ciprofloxacin > penicillins > cefazolin > amoxicillin > penicillin V. Conclusions These findings suggest that the type of antibiotic prescribed in combination with opioid treatment may have important implications on the risk of developing OUD at later time points following hospital discharge.
Ready and Able? Perceptions of Confidence and Teaching Support for First-Year Alternatively Certified Teachers

Abstract To investigate the influence of preservice and in-service supports on teacher perceptions of their confidence to teach and of being supported, this study employed qualitative and quantitative approaches to analyze survey responses and interviews from teachers who received their preparation from a university-led alternative teacher certification program. Survey responses revealed that, prior to entering their classrooms for the first time, participants felt very confident in their ability to teach content, address student differences, manage student behavior, use instructional technology, and meet student needs. This confidence decreased upon entering their classrooms as full-time teaching interns, but survey responses indicated increasing confidence as those internships progressed. In interviews, teachers reported that while their preparation program was influential in shaping their early career experiences and future career plans, it was in-service supports and having a positive relationship with their school administrators which were more meaningful.
The nexus between corporate governance and records management in private and public hospitals in Ghana

Purpose – The purpose of this paper is to examine the relationship between corporate governance and records management in private and public hospitals in Ghana, with the aim of finding out how the effective and efficient management of a hospital's records can facilitate its governance obligations, which includes but not limited to accountability, transparency and information security. Design/methodology/approach – The study was informed by the triangulation of the Stakeholders' and Records Continuum Theories. Data used for analysis were drawn from 90 respondents from four hospitals with the use of questionnaires and personal observations. A total of 82 questionaries' were returned in their complete forms and used for the analysis. Linear regressions were performed to establish the relationship between corporate governance and records management. Findings – The key finding of the study was that, the hospitals generated different types of records in the course of their business activities but existing recor.
Health effects of electromagnetic field generated by lightning current pulses near down conductors

The lightning current generates a time varying magnetic field near down conductors, when lightning strikes the connected Franklin-rod. The down conductors are mounted on the wall of buildings, where residential places can be situated. It is well known that the rapidly changing magnetic fields could generate dangerous eddy currents in the human body. If the duration and the gradient of the magnetic field were high enough, the peripheral nerves are excited. In this study, the authors introduce an improved model of the interaction of electromagnetic fields of lighting current near a down conductor with the human body. The interaction model has two parts: estimation of the magnetic fields surrounding the down conductor and evaluation of health effects of rapid changing magnetic fields on the human body.
Plasmin drives burn-induced systemic inflammatory response syndrome

Severe injuries, such as burns, provoke a systemic inflammatory response syndrome (SIRS) that imposes pathology on all organs. Simultaneously, severe injury also elicits activation of the fibrinolytic protease plasmin. While the principal adverse outcome of plasmin activation in severe injury is compromised hemostasis, plasmin also possesses proinflammatory properties. We hypothesized that, following a severe injury, early activation of plasmin drives SIRS. Plasmin activation was measured and related to injury severity, SIRS, coagulopathy, and outcomes prospectively in burn patients who are not at risk of hemorrhage. Patients exhibited early, significant activation of plasmin that correlated with burn severity, cytokines, coagulopathy, and death. Burn with a concomitant, remote muscle injury was employed in mice to determine the role of plasmin in the cytokine storm and inflammatory cascades in injured tissue distant from the burn injury. Genetic and pharmacologic inhibition of plasmin reduced the burn-induced cytokine storm and inflammatory signaling in injured tissue. These findings demonstrate (a) that severe injury–induced plasmin activation is a key pathologic component of the SIRS-driven cytokine storm and SIRS-activated inflammatory cascades in tissues distant from the inciting injury and (b) that targeted inhibition of plasmin activation may be effective for limiting both hemorrhage and tissue-damaging inflammation following injury.
Hypothetical Mechanism of Exercise-Induced Acute Kidney Injury Associated with Renal Hypouricemia

Renal hypouricemia (RHUC) is a hereditary disease that presents with increased renal urate clearance and hypouricemia due to genetic mutations in the urate transporter URAT1 or GLUT9 that reabsorbs urates in the renal proximal tubule. Exercise-induced acute kidney injury (EIAKI) is known to be a complication of renal hypouricemia. In the skeletal muscle of RHUC patients during exhaustive exercise, the decreased release of endothelial-derived hyperpolarization factor (EDHF) due to hypouricemia might cause the disturbance of exercise hyperemia, which might increase post-exercise urinary urate excretion. In the kidneys of RHUC patients after exhaustive exercise, an intraluminal high concentration of urates in the proximal straight tubule and/or thick ascending limb of Henle’s loop might stimulate the luminal Toll-like receptor 4–myeloid differentiation factor 88–phosphoinositide 3-kinase–mammalian target of rapamycin (luminal TLR4–MyD88–PI3K–mTOR) pathway to activate the nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome and may release interleukin-1β (IL-1β), which might cause the symptoms of EIAKI.
Effect of Romosozumab on Trabecular Bone Score Compared to Anti-Resorptive Agents in Postmenopausal Women with Osteoporosis

Background Romosozumab has shown significant improvement in bone mineral density (BMD) in previously reported trials. However, BMD reflects only bone strength and does not offer insight into the bone microarchitecture. The trabecular bone score (TBS) is a non-invasive tool used to assess bone microarchitecture. Several previous studies have evaluated the efficacy of anti-osteoporotic agents using the TBS. However, data regarding the potency of romosozumab based on the TBS is lacking. This retrospective observational cohort study demonstrated the impact of romosozumab use on the TBS. Methods The primary outcome was the percentage change in the TBS from baseline to post-treatment. Postmenopausal osteoporosis patients were followed up for 6 and 12 months after romosozumab (210 mg monthly, N =10) and denosumab (60 mg every 6 months, N=21) or ibandronate (150 mg monthly, N=24) treatments, respectively. Patients who had previously used osteoporosis medications were included, if any the washout period was sufficient. Results The percentage change in TBS from baseline to post-treatment was 2.53±2.98% (6 months, N=10; P=0.04), 0.59%±3.26% (12 months, N=21; P=0.48), and −0.45±3.66% (12 months, N=24; P=0.51) in the romosozumab, denosumab, and ibandronate groups, respectively. Romosozumab demonstrated a noticeable increase in TBS, although it did not reach the least significant change (5.8%) in TBS. Conclusions Romosozumab improved the TBS in postmenopausal women with osteoporosis. TBS may be potentially useful for monitoring romosozumab treatment.
HEMATOPOIETIC STEM CELL TRANSPLANT IN AGGRESSIVE T AND NK/T CELL LYMPHOMA - ROLE OF UPFRONT AUTOLOGOUS TRANSPLANT IN NODAL PERIPHERAL T-CELL LYMPHOMA

Aggressive T and NK/T-cell lymphoma are known to have a high risk of relapse and poor long-term prognosis. Hematopoietic stem cell transplantation has been performed as part of consolidation or salvage treatment. We retrospectively studied the outcomes of autologous (A) and allogeneic (allo) hematopoietic stem cell transplantation (SCT) in aggressive T and NK/T-cell lymphoma at our center between 2010 to 2020. Patients with nodal peripheral T-cell lymphoma (PTCL) that were younger than 65 years old who did not receive upfront autologous SCT (ASCT) at first complete remission were selected from our registry data for further comparison. Thirty-six patients underwent ASCT, and 16 patients underwent alloSCT. In the ASCT cohort, 18 patients with nodal PTCL who underwent upfront ASCT at first complete remission (upfront ASCT) were compared with 15 patients with nodal PTCL who were in first complete remission after single-line induction but did not receive ASCT. The two-year progression-free survival (PFS) and overall survival (OS) rates for the ASCT cohort were 58% and 73%, respectively. The two-year PFS and OS for the alloSCT cohort were 47% (P=0.35, P=0.02, respectively). Twenty-four patients who received SCT at first remission (21 ASCT and three alloSCT) had a two-year PFS and OS of 75% and 89%, respectively. In comparison, 28 patients who received SCT at relapse/refractory (15 ASCT and 13 alloSCT) had a two-year PFS and OS of 40% and 50%, respectively (P=0.047, P=0.024, respectively). Patients in complete remission prior to transplantation (n=42) had a two-year PFS and OS of 59% and 73%, respectively. In contrast, patients in partial remission prior to transplantation (n=10) had a two-year PFS and OS of 40% and 48%, respectively (p>0.05). Non-relapse mortality occurred in 6% and 43% of ASCT and AlloSCT, respectively. Multivariate analysis revealed that EBV-positivity at diagnosis indicated poorer PFS. EBV-positivity at diagnosis and more than two prior lines of treatment at transplant were associated with poorer OS. For nodal PTCL, the two-year PFS and OS were 79% and 100% for the upfront ASCT cohort and 78% and 92% for the non-upfront ASCT cohort, respectively (p>0.05). Hematopoietic SCT is a feasible treatment option for aggressive T and NK/T-cell lymphoma. Patients who underwent SCT at first remission had better survival rates than those who underwent SCT at relapse/refractory. Nevertheless, due to the limited sample size of the current study, the role of upfront ASCT in patients with nodal PTCL who achieved first complete remission remains unclear.
Numerical optimisation of mechanical reinforcements of weak spots in textiles and garment

Purpose – The purpose of this paper is to investigate and illustrate the possibilities of a systematic engineering approach in the design of mechanical reinforcements in garments. A mechanical reinforcement can be designed using optimisation strategies.Design/methodology/approach – In this work, an iterative algorithm for minimum search based on parabolic approximations is proposed and applied in the optimisation of mechanical reinforcement in a selected model problem of a buttonhole type.Findings – Optimisation algorithm based on parabolic approximations, in conjunction with the finite element analysis, offers some promising possibilities as support for the decision‐making process in the design of mechanical reinforcements. The selection of optimisation criteria – influence parameters and corresponding weight factors – remains of course to be studied and implemented by the clothing engineering experts.Research limitations/implications – The intention in future work should be to optimise two or more geome.
Study of Moment Redistribution in Prestressed Concrete Beams

This paper describes an investigation into the redistribution of moments in certain composite concrete beams. Seven two-span beams 6.2 m long were constructed and tested by means of applying two point loads at midspans. Each beam comprised two precast beams made continuous by a top flange cast “in situ. ” Since the term “redistribution of moments” is normally used in two different meanings (in research papers or in codes of practice), the concept of degree of redistribution is explained. A brief bibliography review presents the main research advances in this subject, and the contradiction between the results is significant in some cases. The experimental program is presented as well as the geometric and material properties of the test beams. The main results obtained from tests are presented from zero loading up to failure. The ultimate loads obtained from the tests are compared with theoretical ones considering both plastic and elastic behavior. Conclusions from the results are presented.
Chemical fractionation of heavy metals in soils around the vicinity of automobile mechanic workshops in Kaduna Metropolis, Nigeria

The study of heavy metals in environmental niches is essential, especially with their potential toxicity to human life. Metal toxicity depends on chemical associations in soils. For this reason, determining the chemical form of a metal in soils is important to evaluate its mobility and bioavailability. In this manner sequential extraction was used to fractionate seven heavy metals (Cd, Cu, Ni, Zn, Cr, Fe and Pb) from ten contaminated soils into six operationally defined groups: water soluble, exchangeable, carbonate, Fe -Mn oxide, organic, and residual. The residual fraction was the most abundant pool for all the metals examined. A significant amount (2.00 to 73.47, 1.77 to 17.78, 9.76 to 58.54 and 1.71 to 54.11% respectively) of Cu, Cd, Cr and Pb was present in the potentially available fraction: non residual fraction. Contamination of Zn, Ni and Fe in these soils was not as severe as Cu, Cd, Cr and Pb. Overall, the order of contamination was Cu > Cr > Pb > Cd > Ni > Zn > Fe. The study indicated that the possible pollution of soils of this environment was as a result of activities carried out within these areas. Key words: Fractionation, heavy metals, mechanic, workshops, Kaduna.
Modeling Pore Continuity and Durability of Cementitious Sealing Material

In this paper, results of a numerical study on pore continuity, permeability and durability of cementitious slurries for carbon sequestration projects are presented. The hydration model Hymostruc is used to simulate and visualize 3D virtual microstructures which are used to demonstrate the contribution of capillary pores to the continuity of the capillary pore system embedded in an evolving cementitious microstructure. Once capillary pores are blocked due to ongoing hydration, transport of CO2 species through the microstructure is avoided which may protect the slurry from leakage. Evaluating the pore continuity of the capillary pore system during hydration of the microstructure is therefore indispensable for a robust cementitious sealing material and is the main objective for slurry design. Simulations are conducted on slurries exposed to ambient temperatures of 20 oC, 40 oC and 60 oC, and a durability outlook regarding the CO2 ingress is given as well. Aggregates and associated interfacial transition zones are introduced in the slurry system that may cause alternative porous path ways through the system. Pore continuity analysis show the relevance of numerical simulations for assessing the capillary pore structure inside an evolving microstructure in relation to its sealing and durability performance.
Providing Worst-Case Latency Guarantees With Collaborative Edge Servers

Mobile Edge Computing (MEC) is a promising computing paradigm that provides cloud computing services in proximity to end users. Due to the bursty and spatially imbalanced arrival of computation tasks, the workload on different edge servers may vary wildly. To improve the Quality of Experience (QoE), peer offloading has been proposed as an effective cooperation method that offloads tasks from busy edge servers to idle ones. Although the average latency has been extensively considered in the design of peer offloading strategies, the worst-case latency, a common Quality of Service (QoS) requirement that is usually demanded by latency-sensitive applications, yet receives much less attention. In this paper, we study the task scheduling among collaborative edge servers and propose an online algorithm that aims to maximize the system utility under the worst-case latency requirement and long-term energy consumption constraints. Both theoretical analysis and simulation results demonstrate that our algorithm performs well under various situations.
A Study of Employability Soft Skills of Final-Year Students: A Case of Gedu College of Business Studies

Employability soft skills is a set of highly desirable, transferable skills that turn one into an attractive employee. It can be defined as a set of skills employers want from a potential employee. This study was designed to evaluate the employability soft skills of Gedu College of Business Studies’ Students and for evaluation, the quantitative research design was adopted. A proportionate sampling method was used and enumerated 228 B. Com and BBA students. Collected data were analyzed using a one-sample t-test and an independent sample t-test. The result reveals that Gedu College of Business Studies’ students possess above-average employability soft skills where the mean score is greater than the test value (3). It further reveals that there is no statistically significant mean difference in employability soft skills between male and female students apart from problem-solving skills which were found statistically significant (p=.046, p<0.05).
Sustainable Team Design: A Challenge to Traditional Beliefs in Information-Intensive Service Industries

Sustainable management activities focus on creating value for organizations. This is particularly relevant in service organizations as they are under increasing pressure to capture and process information efficiently. We advocate that the amount of information and the way teams process this information have a substantial impact on an organization’s ability to sustain a competitive advantage. This study addresses a gap in the literature by examining the impact of the level of information intensity on performance in the service industry. It also contributes to the debate about whether team structure facilitates performance in a service-based organization. A longitudinal design was employed to determine whether information-intensive processes influence performance, and if so, whether the impact differs between team designs. To do this, data were collected from 24,925 motor insurance claims over two distinct time periods. While our findings confirm that information intensity has a direct impact on the performance of claims processing, they also challenge traditional beliefs about self-managed work teams’ dominance. By adopting a more nuanced and context-specific perspective, we discovered that in certain situations the production line approach to team design was more productive than self-directed work teams in respect to critical operational tasks. This research sheds light on a relatively unexplored aspect of the service industry, has implications for sustainable management practices relating to team design, and provides a rich vein for future research studies.
Question of Parity Non-Conservation in Weak Interactions

In order to reasonably explain the phenomenon of cell bioelectricity, we proposed the conservation law of cell membrane area, established the ion inequality equation, and therefore paid attention to the mystery of "θ-τ". We researched and analyzed the "θ-τ" mystery, discussed the parity non-conservation in weak interactions, suggested possible experiments to test the parity non-conservation in weak interactions, and gave our research and analysis conclusions: The experimental scheme proposed by C. N. Yang and T. D. Lee in the hypothesis cannot be used as a positive evidence of whether the weak interaction parity is conserved, nor can it directly answer whether θ and τ in the "θ-τ" mystery are the same particle; The Co60 β decay experiment such as C. S. Wu is a pseudo-mirror experiment, and it has not overturned the so-called "parity conservation law" or proved the "parity non-conservation" in weak interactions; The "θ-τ" mystery is a "man-made" mystery. θ and τ are two different particles, which may be the result of the same precursor particle being divided into two. Parity conservation or non-conservation under mirror image has no physical significance. The work of C. N. Yang, T. D. Lee, C. S. Wu et al. have brought quantum physicists from the "Little black house" to the "Big black house" or "smaller black house". The right and wise choice is to go back through "the door that came in". With the development of science today, it is time for some contents to reform from the bottom.
Prevalence of moisture problems in Finnish houses

Abstract A random sample of 450 houses representing various decades was surveyed by trained civil engineers for signs of water leaks or condensation. In 80% of the houses, signs of current or previous moisture fault were observed. In most houses, the surveyors made at least two separate observations of moisture but the occupants missed one in every two of these signs of moisture damage. Part of the faults were caused by flaws in design or construction, and part were due to aging of materials. Approximately 55% of the Finnish houses (i.e., a total of nearly 500 000 houses), were assessed to be in need of repair or more thorough inspection. The observations were equally frequent in the houses of different age, but certain types of moisture damage were characteristic of certain types of buildings or constructional methods used in different eras. Roof geometry was a significant factor accounting for roof leakages. The majority of the faults could be repaired at reasonable cost.