Miracle-dz/UniFAR-FTUs huggingface dataset:
Ameliorative effect of Andrographis paniculata against oxidative damage caused by cisplatin in rat kidney

The role of ethanolic extract of Andrographis paniculata [AP], in preventing cisplatin [CP] induced oxidative damage in rat kidney was studied. Sixty Wistar Albino rats were divided into five groups with twelve rats in each group. Group I served as normal control group. To group II rats, CP was administered at 7.5mg/kg body weight intraperitoneally for single dose. Rats in group III served as AP control and were administered AP at the dose of 500mg/kg body weight for 45 days. Group IV rats were pre-treated with AP fifteen days prior to CP administration and followed by AP treatment for 45 days. Rats in group V were administered with CP and concurrently treated with AP extract at 500mg/kg by oral gavaging for 45 days. The kidney samples collected at 7, 14, 28, and 45 day of the study were subjected for estimation of catalase, superoxide dismutase, glutathione peroxidase and malondialdehyde [MDA]. Significant decrease [P<0.05] in the levels of antioxidant enzymes and increase in MDA levels were recorded in CP treatment group. The AP treatment groups revealed a significant recovery [P<0.05] all enzymes and decrease in MDA levels which suggested that AP has a good antioxidant effect and could be effectively used for prevention of toxic side effects of CP. The study also indicated that pre-treatment of AP prior to CP administration has good prophylactic effect.
Perspectives on the Management of Infertility in Primary Care: A Survey of Healthcare Providers in a Regional Health Care System in Southwest Virginia

Purpose: The objective of this study is to identify current practice patterns of the primary care providers in the Carilion Clinic system for the evaluation, management, and referral of patients with infertility. Methods: A 15 question survey was emailed to primary care physicians, physician assistants, and nurse practitioners in the Carilion Clinic system. The survey included a demographic analysis of the practice, and provided questions in regards to practice patterns in the evaluation, treatment, and referral of an infertile couple. The inclusion criteria were all PCPs (family medicine, internal medicine). Exclusion criteria included any other field of medicine Results: Twenty-five percent of PCPs in the Carilion network answered the survey. Majority of responders were family medicine (80%), and physicians (80%). Fifty-five percent were female and thirty percent have been practicing medicine for more than 20 years. Half of PCPs were comfortable initiating the diagnostic evaluation of the infertile couple and of these, seventy three percent order diagnostic testing. Less than half (42%) of providers refer patients greater than age 35 that present with infertility for more than 6 months. Conclusion: This survey provides insight into the variation of practice patterns of infertility by primary care providers (PCPs). Although half of PCPs that answered our survey are comfortable initiating the evaluation of the infertile couple, they are not following the current referral guidelines. This can lead to delayed diagnosis, and decreased time to achieve pregnancy. Based on these results, an educational model may be beneficial for PCPs that are interested in the evaluation of the infertile couple.
NDT_A_303226 1713..1722

1NIMH Clinical Center, National Institute of Mental Health Czech Republic, Klecany, Czech Republic; 2Department of Psychiatry and Medical Psychology, Third Medical Faculty, Charles University, Prague, Czech Republic Background: There are no head-to-head studies comparing the antidepressant effect of transcranial direct current stimulation (tDCS) with repetitive transcranial magnetic stimulation (rTMS). This pooled analysis compared indirectly the antidepressant efficacy and acceptability of rTMS, tDCS, and the antidepressant venlafaxine (VNF) extended-release. Methods: The analysis (n=117, both patients with treatment-resistant depression (TRD) and non-TRD were included) examined pooled data from two 4-week, single-centered, twoarmed, double-blind, randomized studies (EUDRACT n. 2005-000826-22 and EUDRACT n. 2015-001639-19). The antidepressant efficacy of right-sided low-frequency rTMS (n=29) vs VNF (n=31) and left-sided anodal tDCS (n=29) vs VNF (n=28) was evaluated. The primary outcome was a change in the Montgomery–Åsberg Depression Rating Scale (MADRS) score from baseline to the treatment endpoint at week 4. The response was defined as a ≥50% reduction in the MADRS score and remission as the MADRS score ≤10 points, both were calculated for the primary treatment endpoint at week 4. Results: Mean change in total MADRS scores from baseline to week 4 was 7.0 (95% CI, 4.8–9.1) points in the rTMS group, 7.6 (95% CI, 5.5–9.8) in the tDCS group, and 8.9 (95% CI, 7.4–10.4) among patients in the VNF group, a non-significant difference (F(2111)=0.62, p=0.54). Similarly, neither the response rates nor remission rates for rTMS (response 31%; remission 17%), tDCS (24%, 17%), or VNF (41%; 27%) significantly differed among treatment groups (χ=2.59, p=0.28; χ=1.66, p=0.44). Twenty patients (17%) dropped out of the studies in a similar proportion across groups (rTMS 3/29, tDCS 6/29, VNF 11/59, χ=1.41, p=0.52). Conclusion: Our current analysis found a comparable efficacy and acceptability in all three treatment modalities (rTMS, tDCS, and VNF) and clinical relevance for the acute treatment of major depressive disorder.
Nutrient Metabolism [C]-Lycopene and [C]-Labeled Polar Products Are Differentially Distributed in Tissues of F344 Rats

Epidemiologic evidence suggests a possible role for lycopene-rich foods in the prevention of prostate cancer and cardiovascular disease. Despite active research in disease reduction, there is a paucity of information on the absorption, biodistribution and metabolism of lycopene. The aim of this study was to evaluate the biodistribution of C-lycopene (specific activity, 1.83 Ci/mg) and C-labeled products after an oral dose of 22 Ci of C-lycopene in male rats that had been prefed a lycopene-containing diet (0.25 g lycopene/ kg diet) for 30 d. The percentage of C excreted in feces and urine over the 168 h was 68%. Quantitatively, serum C levels were maintained between 3 and 24 h then decreased at 72 h (P 0.05). At all time points the majority of tissue C was in the liver ( 72%), although total hepatic C decreased after 24 h. In a comparison of the extrahepatic tissue at 168 h, the C was greatest in adipose tissue followed by spleen and then adrenal; 80% of the C in the liver was in the cis and all-trans configuration at all time points. At 3 h, the C in seminal vesicles was primarily in the all-trans plus 5-cis forms (70%), but by 168 h, 55% of C was present as C-polar products. Despite the presence of unlabeled lycopene in the prostate, the primary C form was in C-polar products (67–92%), even at 3 h. The percentage and amount of C-polar products in the dorsolateral prostate lobe increased from 3 to 24 h and then reached a plateau. The data suggest that lycopene may be metabolized differently among tissues in rats prefed lycopene. J. Nutr. 133: 4189–4195, 2003.
Impact of snow cover on photoinhibition and winter desiccation

and possible interactions with winter desiccation were investigated in situ in an evergreen subalpine woody species, Rhododendron ferrugineum L. , at the alpine timberline (1950 m a.s.l.). Timing and duration of complete snow cover markedly influenced potential efficiency of photosystem II (PSII; Fv /Fm). Lack of snow cover led to severe but mostly reversible photoinhibition with Fv/Fm values as low as 0.05. Complete snow cover immediately stopped further reductions in PSII efficiency. Snow cover promoted recovery from photoinhibition, but only if, in addition to shading by snow, plants were exposed to nonfreezing temperatures close to 0 °C. The Fv /Fm ratio was closely related to minimum leaf temperatures because both photoinhibition and recovery from photoinhibition were strongly influenced by temperature. The period without major reductions in PSII efficiency lasted for only two months, reflecting the extremely short growing period in the subalpine environment. Compared with complete snow cover, incomplete snow cover led to significantly higher water losses as well as lower dehydration tolerance, because both osmotic adjustment and changes in turgor maintenance capacity were significantly reduced. Interactions between photoinhibition and winter desiccation were masked by the direct effects of freezing temperatures. However, both photoinhibition and winter desiccation are closely linked and occur together under field conditions in this evergreen subalpine woody species.
Systematic Review With Network Meta-Analysis

AbstractThere are 5 major adjuvant chemotherapies (ACTs) for hepatic metastases for colorectal cancer; however, the optimal treatment regimen remains inconclusive. Here, we aim to compare these therapies in terms of patient survival rate, intrahepatic recurrence rate, and adverse events.Different databases were searched for controlled trials up to June 30, 2014. The pooled hazards ratios for death and odds ratios (ORs) for intrahepatic recurrence and adverse events were estimated. A mean ranking and the probability of optimal therapeutic regime was obtained for each treatment analyzed in the network meta-analysis.Eleven eligible articles were included. Systemic chemotherapy (SCT) was ranked the most efficacious intervention among ACTs in both 1-year and 5-year survival; however, no statistical difference could be determined. Combination of bevacizumab (BEV) and hepatic arterial infusion (HAI) plus SCT was the most effective in preventing intrahepatic recurrence when compared with HAI alone (OR 1.21, 95% confidence interval [CI] 0.01–131.12), SCT (OR 2.37, 95% CI 0.03–234.16), HAI plus SCT (OR 0.97, 95% CI 0.03–35.30), SCT plus irinotecan (OR 1.01, 95% CI 0.00–278.14) and observation alone (OR 0.83, 95% CI 0.01–59.53). BEV and HAI plus SCT provided the least survival benefit after both 1 and 5 years compared with remaining therapies, and also was ranked the regiment with the least favorable adverse event profile among ACTs.SCT may be the most efficacious intervention, however, the potential benefit should be carefully considered with the regime's associated toxicities. Combination of BEV and HAI plus SCT was effective in preventing intrahepatic relapse but was associated with the highest risk for adverse events in patients with resected hepatic metastases for colorectal cancer.
PREVALENCE, PATTERN OF PRESENTATION AND MANAGEMENT OF BARTHOLIN’S GLAND CYST/ABSCESS AT USMANU DANFODIO UNIVERSITY TEACHING HOSPITAL, SOKOTO: A TEN YEAR REVIEW

Background: The Bartholin’s gland cysts and abscesses are one of the common vulva cyst or abscesses in gynaecological practice. Symptomatic cases give significant discomfort to affected individuals and have a negative impact on their quality of life. Aim of Study: The study was aimed at determining the prevalence, pattern of presentation and management of Bartholin’s gland cysts and abscesses at Usmanu Danfodiyo University Teaching Hospital, Sokoto State. Material and Method: This was a ten-year retrospective study of cases of Bartholin’s gland cysts and abscesses that were managed at UDUTH from 1st January 2009 to 31st December 2018. Results: During the study period, there were 3,924 gynaecological surgical cases managed, among which 81 were Bartholin’s gland cysts and abscess (19 were cysts and 62 were abscesses) giving prevalence of 2.02%. The mean age of the patients was 26.3 ± 3.9 years with 44% of them being within the age range of 25 to 29 years. There was previous history of the condition in 52% of the cases. Previous history was the commonest risk factor that was found for the occurrence of Bartholin’s gland cyst or abscess and this was followed by previous history of sexually transmitted disease in 40% of the cases. Pain and swelling were the commonest presenting symptoms in 65.3% of cases. The left vulva was the commonest site affected as seen in 70.7% of the patients. Swab culture result were retrieved only in 30 patient and Escherichia coli was the commonest organism isolated in 86.7% of the cases. The disease presented commonly in form of abscess as observed in 58 (77.3%) of patients then cyst in 17(22.7%). All the patients had Marsupialisation as the modality of treatment. Conclusion: The prevalence of Bartholin’s gland cyst and abscess in this study was 2.02%. Left bartholin’s gland was the commonest site affected. Escheriria coli was the predominant organisms isolated among the cases managed during the years under review. Marsupialisation remains the mainstay of treatment in low resource setting.
RMHP_A_313387 2601..2608

Department of Medical Laboratory Science, Debre Berhan University, Debre Berhan, Ethiopia Background: Mobile Phone (MP) handling by healthcare workers (HCWs) in hospital is an open breeding place for the transmission of bacteria and healthcare-associated infection (HCAI). This HCAI is a huge problem to the healthcare system worldwide. Methods: A laboratory-based cross-sectional study design was conducted from January 2020 to January 2021 in Debre Berhan Referral Hospital, North Shoa Zone, Ethiopia. A total of 65 swab samples were collected from HCWs mobiles phone. Other important data were collected using a self-administered questionnaire. The collected samples were processed for bacteriological identification and drug susceptibility testing. Data obtained were entered and cleaned into MS Excel spreadsheet and analyzed using SPSS version 21. Results: From the total of 65 swab sample, 84 bacterial isolates were detected. Of these bacterial isolates, 46.4% were Gram-positive bacteria while 53.6% were Gram-negative bacteria. The overall MDR prevalence was found to be 42.9%. The proportion of MP contamination was higher in males (67.9%) and the age groups of 20–35 years (50%). All the MP carried by HCWs was contaminated with at least one bacterial pathogen. The high rate of MP contamination was observed in the intensive care unit (ICU) (22.6%) followed by surgical ward (17.8) and laboratory rooms (17.8%). The rate of bacterial contamination of MP was higher among HCWs working in ICU, who did not disinfect or clean their phone regularly and who did not wash their hands regularly. Conclusion: Healthcare worker’s MP was contaminated with pathogenic bacteria. Since MP could serve as a vehicle and a reservoir for pathogenic bacteria, HCWs should be aware of the public health risks of HCAI, and appropriate intervention mechanisms should be practiced to reduce the burden and cross-transmission.
AxisSusceptibility Genes by the IRF5/Blimp-1 Distinct Regulation of Murine Lupus

Genome-wide association studies have identiﬁed lupus susceptibility genes such as IRF5 and PRDM1 (encoding for IFN regulatory factor 5 [IRF]5 and Blimp-1) in the human genome. Accordingly, the murine Irf5 and Prdm1 genes have been shown to play a role in lupus susceptibility. However, it remains unclear how IRF5 and Blimp-1 (a transcriptional target of IRF5) contribute to lupus susceptibility. Given that the murine lupus susceptibility locus Nba2 includes the IFN-regulated genes Iﬁ202 (encoding for the p202 protein), Aim2 (encoding for the Aim2 protein), and Fcgr2b (encoding for the Fc g RIIB receptor), we investigated whether the IRF5/Blimp-1 axis could regulate the expression of these genes. We found that an Irf5 deﬁciency in mice decreased the expression of Blimp-1 and reduced the expression of the Iﬁ202 . However, the deﬁciency increased the expression of Aim2 and Fcgr2b . Correspondingly, increased expression of IRF5 in cells increased levels of Blimp-1 and p202 protein. Moreover, Blimp-1 expression increased the expression of Iﬁ202 , whereas it reduced the expression of Aim2 . Interestingly, an Aim2 deﬁciency in female mice increased the expression of IRF5. Similarly, the Fcgr2b- deﬁcient mice expressed increased levels of IRF5. Moreover, increased expression of IRF5 and Blimp-1 in lupus-prone C57BL/6. Nba2 , New Zealand Black, and C57BL/6. Sle123 female mice (as compared with age-matched C57BL/6 female mice) was associated with increased levels of the p202 protein. Taken together, our observations demonstrate that the IRF5/Blimp-1 axis differentially regulates the expression of Nba2 lupus susceptibility genes, and they suggest an important role for the IRF5/Blimp-1/p202 axis in murine lupus susceptibility. Journal Immunology , 2012, 188:
A Resource-Based View of Elite Kenyan Running Successes

The purpose of this book is to add onto the many theories that have been previously used to explain the Kenyan Endurance running successes.The book specifically focuses on how resources have impacted Kenyan Endurance running especially from 1991 onward. The book is also the first to employ the combined use of the resource-based theory with statistical evidence to examine the potential ‘causes’ of Kenyan Endurance running successes.The book will be a valuable and fine read for students, journalists, sports coaches, managers and administrators, as well as policy analysts.
An Algorithm to Evaluate and Build Schedules for a Distributed Sensor System with Respect to Clock Synchronization

—Distributed embedded systems utilizing active sensors that share a common media (e.g., light detection and ranging sensors, LIDAR) have to be coordinated to eliminate or reduce interferences between the different sensor nodes. For LIDAR and similar sensor systems it is possible to apply media access methods, like frequency, code and time division multiple access (FDMA, CDMA or TDMA). FDMA and CDMA methods utilize sensor speciﬁc parameters for medium access. This can be a drawback, as it is no longer possible or far more difﬁcult to use error correction or measurement enhancement techniques, like multi-frequency measurements, that depend on these parameters. A TDMA scheme frees these sensor speciﬁc parameters, but needs additional infrastructure in the form of clock synchronization. The implementation of the synchronization mechanism constrains the TDMA schedules that can be executed. This paper provides an algorithm to ascertain these constraints, and thus determine the requirements for the synchronization mechanism implementation.
acid for the selective

Utilization of strawberry and raspberry waste for the extraction bioactive ABSTRACT 23 Deep eutectic solvents were used for the recovery of bioactive compounds from 24 strawberry and raspberry by-products. The best performing eutectic solvent (DES-7) 25 was compared to one organic solvent. Total and individual phenolics, sugars, uronic 26 acid, anthocyanins and the antioxidant activity in vitro were measured. The highest 27 yield and purity of phenolic compounds in the extracts were obtained from strawberry 28 extrudate with acetone (11.5 %) and from raspberry extrudate (36.7 %) with DES-7. 29 The greatest yields of total sugars and acid sugars were achieved from raspberry 30 extrudate using acetone and from strawberry extrudate using DES-7, 82.23 and 1.88 31 mg/g of extract, respectively. DES-7 was the solvent that extracted the most 32 anthocyanins (1.28 mg/100 mg of extract). In addition, the extracts obtained with 33 acetone presented the best values of antioxidant activity in vitro (DPPH value of 5.33 34 mmol TE/kg fresh weight and ORAC value of 37.89 µmol TE/g fresh weight) the 35 extracts obtained with DES-7 also presented an interesting antioxidant activity, and a 36 promising solvent for the extraction of bioactive compounds. 37 39
Spatiotemporal geostatistics applied to surface albedo: The case of southern Minas Gerais (Brazil)

Several science areas have data coming characterized by variations in space and time that are measured using statistical procedures that take into account or not the existing interactions between the dimensions of space and time. Gneiting, in 2002, proposed a model that is based on the construction of non-separable stationary covariance functions, given the condition of being positive definite, which can be used to model the covariance matrix used in kriging. The southern mesoregion of Minas Gerais is very important to Brazilian agribusiness due to the planting of coffee cultivar and also because it has an extensive pasture area, allowing the creation of cattle, horses, and pigs and, for this reason, it is essential to study factors that impact on the climate of this region as the Earth's surface albedo, which is defined as the ability of a surface to reflect solar radiation. This article's objective is to apply the covariance model presented by Gneiting to the Geostatistical modeling of a set of real data on the albedo of the Earth's surface in the mesoregion in question using ordinary kriging to predict data of this nature. We choose to use the linear kriging predictor as it has the property of being best linear unbiased prediction (BLUP). We conclude that the exponential-cauchy family belonging to the class of covariance functions presented by Gneiting obtained a lower MSE in the adjustment of the covariance matrix of the linear kriging predictor and, therefore, can be used to predict the Earth's surface albedo.
Running head: Design principles of transit peptides

To whom all correspondence should be addressed: 6 7 Inhwan Hwang 8 Division of Integrative Biosciences and Biotechnology and Department of Life Sciences, 9 Pohang University of Science and Technology, Pohang, 790-784, Korea 10 11 E-mail address: ihhwang@postech.ac. kr 12 Tel: 82-54-279-2128 13 Fax: 82-54-279-8159 14 15 16 17 18 Plant Physiology Preview. Published on July 22, 2015, as DOI:10.1104/pp.15. 00842
Design model for dry-stacked and demountable masonry blocks

[Abstract]. The construction industry around the world produces a large part of inert wastes mainly coming from building demolitions. Facing to this environmental challenge and considering the new policy initiatives supporting the designing of sustainable buildings, dry-stacked masonry comes forward as a promising solution since components can be dismantled, saved in a component bank and reassembled on new sites. The speedy growth of the construction industry, the increasing importance given to the complete life cycle of buildings and the evolution of construction technics have led to the development of dry-stacked masonry structures. Mortarless masonry structures minimise skilled labour requirements and improve construction productivity. However, despite these advantages, there are no design standards providing guidelines to assess the load-bearing capacity of dry-stacked masonry block, which therefore limits its use in construction. In an attempt to fill this lack, the current paper investigates the load-bearing capacity of dry-stacked masonry and its influencing parameters. The effects of the geometric imperfections such as height imperfections and bed-joint roughness have been analysed as well as a mitigation strategy. Then, based on experimental evidence, a design method has been proposed for dry-stacked masonry solicited by axial compression. The developed design methodology provided promising results, with 93% of accuracy in the prediction of the dry-stacked masonry’s’ load-bearing capacity.
A circularly polarized conical beam spherical slot array antenna

This paper proposes a circularly polarized conical beam spherical slot array antenna which is suitable for a low elevation angle land mobile satellite communication subscriber. The structure of this antenna type is very simple to fabricate; i.e. a ring of perpendicular slot pairs is cut on an outer surface of a concentric conducting spherical cavity. From the assumption of weak coupling of the slots from the cavity, the conical beam pattern can be obtained. Experimental results that verify the conical beam radiation are in good agreement with the design.