Miracle-dz/UniFAR-FTUs huggingface dataset:
Software-reliability evaluation of the TROPICO-R switching system

The analysis and evaluation of the software of the TROPICO-R switching system are described. Failure data were collected over 27 months, including validation phase, field trial phase, and operational life. During this period 461 failure reports have been recorded. Two models (exponential and S-shaped) have been applied to these failure data, and have been analyzed according to their repetitive and predictive capabilities. It is found that it is difficult for the models to reproduce the observed failure data when changes in trend do not follow the model assumptions. The Laplace trend test is a major tool for guiding the partitioning of failure data according to the assumptions of model reliability growth. Only the S-shaped model has been considered for the analysis according to trend periods. Prediction yields good results over a time period of a few months, showing that reliability modeling is a major tool for test/maintenance planning and follow-up. >
Large sets of coverings

Large sets of packings were investigated extensively. Much less is known about the dual problem, i.e., large sets of coverings. We examine two types of important questions in this context; what is the maximum number of disjoint optimal coverings? and what is the minimum number of optimal coverings for which the union covers the space? We give various constructions which give the optimal solutions and some good upper and lower bounds on both questions, respectively. © 1994 John Wiley & Sons, Inc.
Recombination Variation Shapes Phylogeny and Introgression in Wild Diploid Strawberries

Abstract Introgressive hybridization is widespread in wild plants and has important consequences. However, frequent hybridization between species makes the estimation of the species’ phylogeny challenging, and little is known about the genomic landscape of introgression as it results from complex interactions of multiple evolutionary processes. Here, we reconstructed the phylogeny of ten wild diploid strawberries with whole genome resequencing data and then investigated the influence of recombination rate variation on phylogeny and introgression. We found that genomic regions with low recombination showed reduced levels of incomplete lineage sorting and introgression, and concentrated phylogenetic signals, thus contributing to the most likely species tree of wild diploid strawberries. We revealed complex and widespread introgression across the genus Fragaria, with an average proportion of approximately 4.1% of the extant genome. Introgression tends to be retained in the regions with high recombination rates and low gene density. Furthermore, we identified four SLF genes under selective sweeps that may play potential roles in the possible regain of self-incompatibility by ancient introgression. Altogether, our study yielded novel insights into the evolutionary history and genomic characteristics of introgression in wild diploid strawberries and provides evidence for the role of introgression in plant mating system transitions.
Examining the Distribution of Bone Bruise Patterns in Contact and Noncontact Acute Anterior Cruciate Ligament Injuries

Background: Bone bruises are commonly seen on magnetic resonance imaging (MRI) in acute anterior cruciate ligament (ACL) injuries and can provide insight into the underlying mechanism of injury. There are limited reports that have compared the bone bruise patterns between contact and noncontact mechanisms of ACL injury. Purpose: To examine and compare the number and location of bone bruises in contact and noncontact ACL injuries. Study Design: Cross-sectional study; Level of evidence, 3. Methods: Three hundred twenty patients who underwent ACL reconstruction surgery between 2015 and 2021 were identified. Inclusion criteria were clear documentation of the mechanism of injury and MRI within 30 days of the injury on a 3-T scanner. Patients with concomitant fractures, injuries to the posterolateral corner or posterior cruciate ligament, and/or previous ipsilateral knee injury were excluded. Patients were stratified into 2 cohorts based on a contact or noncontact mechanism. Preoperative MRI scans were retrospectively reviewed by 2 musculoskeletal radiologists for bone bruises. The number and location of the bone bruises were recorded in the coronal and sagittal planes using fat-suppressed T2-weighted images and a standardized mapping technique. Lateral and medial meniscal tears were recorded from the operative notes, while medial collateral ligament (MCL) injuries were graded on MRI. Results: A total of 220 patients were included, with 142 (64.5%) noncontact injuries and 78 (35.5%) contact injuries. There was a significantly higher frequency of men in the contact cohort compared with the noncontact cohort (69.2% vs 54.2%, P = .030), while age and body mass index were comparable between the 2 cohorts. The bivariate analysis demonstrated a significantly higher rate of combined lateral tibiofemoral (lateral femoral condyle [LFC] + lateral tibial plateau [LTP]) bone bruises (82.1% vs 48.6%, P < .001) and a lower rate of combined medial tibiofemoral (medial femoral condyle [MFC] + medial tibial plateau [MTP]) bone bruises (39.7% vs 66.2%, P < .001) in knees with contact injuries. Similarly, noncontact injuries had a significantly higher rate of centrally located MFC bone bruises (80.3% vs 61.5%, P = .003) and posteriorly located MTP bruises (66.2% vs 52.6%, P = .047). When controlling for age and sex, the multivariate logistical regression model demonstrated that knees with contact injuries were more likely to have LTP bone bruises (OR, 4.721 [95% CI, 1.147-19.433], P = .032) and less likely to have combined medial tibiofemoral (MFC + MTP) bone bruises (OR, 0.331 [95% CI, 0.144-0.762], P = .009) compared with those with noncontact injuries. Conclusion: Significantly different bone bruise patterns were observed on MRI based on ACL injury mechanism, with contact and noncontact injuries demonstrating characteristic findings in the lateral tibiofemoral and medial tibiofemoral compartments, respectively.
Community acquired and hospital acquired AKI - two diseases divided by a common definition

Purpose of review Acute kidney injury (AKI) is common across the world. AKI that is acquired in the community (community acquired AKI, CA-AKI) has different risk factors, epidemiological profile, presentation and impact as compared to hospital acquired AKI (HA-AKI). Hence, similar approaches to tackle CA-AKI and HA-AKI might not work. This review highlights the important differences between the two entities that have a bearing on the overall approach to the conditions and how CA-AKI has been overshadowed by HA-AKI in research, diagnosis and treatment recommendations and clinical practice guidelines. Recent findings The overall burden of AKI is disproportionately more in low and low-middle income countries. The Global Snapshot study of International Society of Nephrology's (ISN) AKI 0by25 program has shown that CA-AKI is the dominant form in these settings. Its profile and outcomes vary with geographical and socio-economic characteristics of the regions where it develops. The current clinical practice guidelines for AKI align more with HA-AKI than CA-AKI, and fail to capture the complete spectrum of CA-AKI as well as its impact. The ISN AKI 0by25 studies have uncovered the circumstantial compulsions in defining and assessing AKI in these settings and shown feasibility of community-based interventions. Summary Efforts are needed to better understand CA-AKI in low-resource settings and develop context specific guidance and interventions. A multidisciplinary, collaborative approach with representation from community would be required.
Influence of Secondary Flow Injection Angle on a Fluidic Shock Control Technique

The influence of the secondary flow injection angle on a fluidic shock control technique that is used to control the ramp shock of supersonic and hypersonic inlets is studied in this paper. The differential equation of the momentum thickness of the boundary layer, the injection ratio, and the secondary flow injection angle is first deduced. Then, the relation of the secondary flow injection ratio with the displacement of the first ramp shock is established. Based on this, a theoretical prediction method of the required secondary mass flow ratio for a given shock control requirement is developed in an iterative manner and then validated by both numerical simulations and wind-tunnel tests. The theoretical analysis shows that the momentum thickness development rate of the boundary layer is closely related to the dimensionless tangential velocity of the secondary flow and the injection ratio. Although the desired displacement of the first ramp shock remains the same, the required secondary mass flow ratio dec.
The Impact of Context on Students’ Framing and Reasoning about Fluid Dynamics

Contextual features of assessments can influence the ideas students draw from and the ways they assemble knowledge. We used a mixed-methods approach to explore how surface-level item context impacts student reasoning. In study 1, we developed an isomorphic survey to capture student reasoning about fluid dynamics, a crosscutting phenomenon, in two item contexts (blood vessels, water pipes), and administered the survey to students in two different course contexts: human anatomy and physiology (HA&P) and physics. We observed a significant difference in two of 16 between-context comparisons and a significant difference in how HA&P students responded to our survey compared with physics students. In study 2, we conducted interviews with HA&P students to explore our findings from study 1. Using the resources and framing theoretical framework, we found that HA&P students responding to the blood vessel protocol used teleological cognitive resources more frequently compared with HA&P students responding to the water pipes version. Further, students reasoning about water pipes spontaneously introduced HA&P content. Our findings support a dynamic model of cognition and align with previous work suggesting item context impacts student reasoning. These results also underscore a need for instructors to recognize the impact of context on student reasoning about crosscutting phenomena.
Impaired dopamine release in Parkinson’s disease

Abstract Parkinson’s disease is the second most common neurodegenerative disease and yet the early pathophysiological events of the condition and sequences of dysfunction remain unclear. The loss of dopaminergic neurons and reduced levels of striatal dopamine are descriptions used interchangeably as underlying the motor deficits in Parkinson’s disease. However, decades of research suggest that dopamine release deficits in Parkinson’s disease do not occur only after cell death, but that there is dysfunction or dysregulation of axonal dopamine release before cell loss. Here we review the evidence for dopamine release deficits prior to neurodegeneration in Parkinson’s disease, drawn from a large and emerging range of Parkinson’s disease models, and the mechanisms by which these release deficits occur. The evidence indicates that impaired dopamine release can result from disruption to a diverse range of Parkinson’s disease-associated genetic and molecular disturbances, and can be considered as a potential pathophysiological hallmark of Parkinson’s disease.
How Predictable is the Indian Ocean Dipole

In light of the growing recognition of the role of surface temperature variations in the Indian Ocean for driving global climate variability, the predictive skill of the sea surface temperature (SST) anomalies associated with the Indian Ocean dipole (IOD) is assessed using ensemble seasonal forecasts from a selection of contemporary coupled climate models that are routinely used to make seasonal climate predictions. The authors assess predictions from successive versions of the Australian Bureau of Meteorology Predictive Ocean‐Atmosphere Model for Australia (POAMA 15b and 24), successive versions of the NCEP Climate Forecast System (CFSv1 and CFSv2), the ECMWF seasonal forecast System 3 (ECSys3), and the Frontier Research Centre for Global Change system (SINTEX-F) using seasonal hindcasts initialized each month from January 1982 to December 2006. The lead time for skillful prediction of SST in the western Indian Ocean is found to be about 5‐6 months while in the eastern Indian Ocean it is only 3‐4 months when all start months are considered. For the IOD events,whichhavemaximumamplitudeintheSeptember‐November(SON)season,skillfulpredictionisalso limited to a lead time of about one season, although skillful prediction of large IOD events can be longer than this, perhaps up to about two seasons. However, the tendency for the models to overpredict the occurrence of large events limits the confidence of the predictions of these large events. Some common model errors, in(
Ready for handwriting? A reference data study on handwriting readiness assessments

Introduction Early evaluation of writing readiness is essential to predict and prevent handwriting difficulties and its negative influences on school occupations. An occupation-based measurement for kindergarten children has been previously developed: Writing Readiness Inventory Tool In Context (WRITIC). In addition, to assess fine motor coordination two tests are frequently used in children with handwriting difficulties: the modified Timed Test of In-Hand Manipulation (Timed TIHM) and the Nine-Hole Peg Test (9-HPT). However, no Dutch reference data are available. Aim To provide reference data for (1) WRITIC, (2) Timed-TIHM and (3) 9-HPT for handwriting readiness assessment in kindergarten children. Methods Three hundred and seventy-four children from Dutch kindergartens in the age of 5 to 6.5 years (5.6±0.4 years, 190 boys/184 girls) participated in the study. Children were recruited at Dutch kindergartens. Full classes of the last year were tested, children were excluded if there was a medical diagnosis such as a visual, auditory, motor or intellectual impairment that hinder handwriting performance. Descriptive statistics and percentiles scores were calculated. The score of the WRITIC (possible score 0–48 points) and the performance time on the Timed-TIHM and 9-HPT are classified as percentile scores lower than the 15th percentile to distinguish low performance from adequate performance. The percentile scores can be used to identify children that are possibly at risk developing handwriting difficulties in first grade. Results WRITIC scores ranged from 23 to 48 (41±4.4), Timed-TIHM ranged from 17.9 to 64.5 seconds (31.4± 7.4 seconds) and 9-HPT ranged from 18.2 to 48.3 seconds (28.4± 5.4). A WRITIC score between 0–36, a performance time of more than 39.6 seconds on the Timed-TIHM and more than 33.8 seconds on the 9-HPT were classified as low performance. Conclusion The reference data of the WRITIC allow to assess which children are possibly at risk developing handwriting difficulties.
The impact of the BEL intervention on levels of motivation, engagement and recovery in people who attend community mental health services

Abstract Background Community-based day centres (DC) in Sweden provide support to people with severe mental health problems. The role of DC motivation for outcomes in terms of occupational engagement and personal recovery is yet unknown. Aims To compare two groups who received DC services, one of which also received the 16-week Balancing Everyday Life (BEL) intervention. The focus was motivation for DC services at baseline and after 16 weeks of services, while also investigating the importance of DC motivation for the selected outcomes and service satisfaction. Material and Methods Sixty-five DC attendees were randomised to BEL (n = 27) or standard support (n = 38) and responded to questionnaires about motivation, the selected outcomes and satisfaction with DC services. Results The groups did not differ on any measured aspects of motivation; nor were changes seen over time. The BEL group, but not those receiving standard support, improved from baseline to 16 weeks on occupational engagement and recovery. Motivation for attending the DC was related to service satisfaction. Conclusion The BEL program could be a viable enrichment tool in the DC context and boost occupational engagement and personal recovery among the attendees. Significance The study provided knowledge of importance when developing community-based services while enhancing motivation.
Healthcare resource utilization and costs of care in the United States for patients with non-alcoholic steatohepatitis

Abstract Aims This retrospective, observational cohort study aimed to determine the burden of comorbidities, hospitalization, and healthcare costs among patients with non-alcoholic steatohepatitis (NASH) in the United States stratified by fibrosis-4 (FIB-4) or body mass index (BMI). Methods Adults with NASH were identified in the Veradigm Health Insights Electronic Health Record Database and linked Komodo claims data. The index date was the earliest coded NASH diagnosis between 1 January 2016 and 31 December 2020 with valid FIB-4 and ≥6 months of database activity and continuous enrollment pre- and post-index. We excluded patients with viral hepatitis, alcohol-use disorder, or alcoholic liver disease. Patients were stratified by FIB-4: FIB-4 ≤ 0.95, 0.95 < FIB-4 ≤ 2.67, 2.67 < FIB-4 ≤ 4.12, FIB-4 > 4.12) or BMI (BMI <25, 25 ≤ BMI ≤30, BMI > 30). Multivariate analysis was used to assess the relationship of FIB-4 with costs and hospitalizations. Results Among 6,743 qualifying patients, index FIB-4 was ≤0.95 for 2,345 patents, 0.95–2.67 for 3,289 patients, 2.67–4.12 for 571 patients, and >4.12 for 538 patients (mean age 55.8 years; 62.9% female). Mean age, comorbidity burden, cardiovascular disease risk, and healthcare utilization increased with increasing FIB-4. Mean ± SD annual costs increased from $16,744±$53,810 to $34,667±$67,691 between the lowest and highest FIB-4 cohorts and were higher among patients with BMI <25 ($24,568±$81,250) than BMI >30 ($21,542±$61,490). A one-unit increase in FIB-4 at index was associated with a 3.4% (95%CI: 1.7%–5.2%) increase in mean total annual cost and an 11.6% (95%CI: 8.0%–15.3%) increased likelihood of hospitalization. Conclusions A higher FIB-4 was associated with increased healthcare costs and risk of hospitalization in adults with NASH; however, even patients with FIB-4 ≤ 0.95 presented a significant burden.
Fractal characteristics of electrical discharges : experiments and simulation

It has been demonstrated that the general topological characteristics of branched electrical discharges can be efficiently described by the concept of fractal geometry. However, researches carried out on this subject hitherto have been restricted to computer simulation of discharge patterns without reference to experimental data and physical discharge mechanisms. In the work, therefore, a specific discharge type is studied, namely a Lichtenberg figure in SF6, for which experimental results are presented together with a discussion of the underlying physical processes and numerical simulations. Good agreement is found between experiment and simulation and it is shown that the approximate fractal scaling of the discharge figure is a consequence of specific underlying physical mechanisms.
Expanding the genetic spectrum of giant axonal neuropathy: Two novel variants in Iranian families

Giant axonal neuropathy (GAN) is a progressive childhood hereditary polyneuropathy that affects both the peripheral and central nervous systems. Disease‐causing variants in the gigaxonin gene (GAN) cause autosomal recessive giant axonal neuropathy. Facial weakness, nystagmus, scoliosis, kinky or curly hair, pyramidal and cerebellar signs, and sensory and motor axonal neuropathy are the main symptoms of this disorder. Here, we report two novel variants in the GAN gene from two unrelated Iranian families.
On Weak Annihilator Ideals of Skew Monoid Rings

As generalizations of annihilators and associated primes, we introduce the notions of weak annihilators and weak associated primes, respectively. We first study the properties of the weak annihilator of a subset X in a ring R. We next investigate how the weak associated primes of a ring R behave under passage to the skew monoid ring R*M. Let R be a semicommutative ring, and M an ordered monoid and φ: M → Aut(R) a compatible monoid homomorphism. Then we can describe all weak associated primes of the skew monoid ring R*M in terms of the weak associated primes of R in a very straightforward way.
Later school start time is associated with longer school day sleep duration and less social jetlag among Norwegian high school students: Results from a large‐scale, cross‐sectional study

The present study explored the associations between school start time and sleep habits among older adolescents, and whether these associations depended on circadian preference. The sample comprised 4010 high school students aged 16–17 years who completed a web‐based survey on habitual school start time, sleep, and health. The survey included the Munich ChronoType Questionnaire, and the short version of the Horne–Östberg Morningness–Eveningness Questionnaire. Students were categorised according to habitual school start time (before 08:00 hours, 08:00 hours, 08:15 hours, 08:30 hours or after 08:30 hours) and circadian preference (morning, intermediate or evening). Data were analysed using two‐way analyses of variance (school start time × circadian preference) and linear regression analyses. Results showed an overall effect of school start time on school day sleep duration (main effect, p < 0.001), with the latest school starters having the longest, and the earliest school starters having the shortest sleep duration (7:03 hr versus 6:16 hr; Tukey HSD p < 0.001). Similarly, later school starters generally reported shorter social jetlag and later school day wake‐up times than earlier starting students (both main effect p < 0.001). Circadian preference did not modify these associations (interaction effects p > 0.05). In the crude regression analysis, 15 min later school start was associated with 7.2 min more sleep (p < 0.001). School start time remained a significant predictor of school day sleep duration when adjusted for sex, parental educational level and circadian preference (p < 0.001). Results suggest that school start time is a significant predictor of school day sleep duration among adolescents.
SLC26A9 in airways and intestine: secretion or absorption?

ABSTRACT SLC26A9 is one out of 11 proteins that belong to the SLC26A family of anion transporters. Apart from expression in the gastrointestinal tract, SLC26A9 is also found in the respiratory system, in male tissues and in the skin. SLC26A9 has gained attention because of its modifier role in the gastrointestinal manifestation of cystic fibrosis (CF). SLC26A9 appears to have an impact on the extent of intestinal obstruction caused by meconium ileus. SLC26A9 supports duodenal bicarbonate secretion, but was assumed to provide a basal Cl- secretory pathway in airways. However, recent results show that basal airway Cl- secretion is due to cystic fibrosis conductance regulator (CFTR), while SLC26A9 may rather secrete HCO3-, thereby maintaining proper airway surface liquid (ASL) pH. Moreover, SLC26A9 does not secrete but probably supports reabsorption of fluid particularly in the alveolar space, which explains early death by neonatal distress in Slc26a9-knockout animals. While the novel SLC26A9 inhibitor S9-A13 helped to unmask the role of SLC26A9 in the airways, it also provided evidence for an additional role in acid secretion by gastric parietal cells. Here we discuss recent data on the function of SLC26A9 in airways and gut, and how S9-A13 may be useful in unraveling the physiological role of SLC26A9.