Miracle-dz/UniFAR-FTUs huggingface dataset:
Effects of using compound or complex strength-power training during in-season in team sports

ABSTRACT Literature is scarce on how players with poorly and well developed physical qualities respond to different combinations of strength-power training during in-season. The aim of this study was to investigate the effects of (i) compound training performed by stronger athletes at different days and (ii) complex training performed by weaker athletes within the same training session. Twenty male handball players were classified as strong or weak according to countermovement jump performance and assigned to a 12-week training programme. Linear sprint, changes of direction, repeated sprint ability and vertical jump capacity were used to assess physical profiles. Compound training performed by stronger players resulted in unclear effects on vertical jump, 20-m and repeated sprint. Likely improvements were found in 10-m sprint (−11.3%; 11.9%). Weaker players who performed complex training presented likely and very likely improvements on vertical jump (13.7%; 5.4%), sprint (10 m, −10.7%; 10.3%; 20 m, −6.0%; 3.4%) and repeated sprint (−4.1%; 3.7%) with moderate to large effect size. The results show that complex and compound strategies are useful in improving the physical profiles of weaker players and maintaining stronger players’ capacities during in-season, respectively. Players involved in the same competitive context, even from the same team, may require different strength training strategies.
Awareness and Response to Human Immunodeficiency Virus / Acquired Immune Deficiency Syndrome (HIV/AIDS) among University Students in Abeokuta, Nigeria

The acquisition of knowledge and accessibility to information is essentially relevant to Voluntary Counseling and Testing (VCT) in any developing country. VCTs are increasingly important in global response to Human Immunodeficiency Virus/Acquired Immune Deficiency Syndrome HIV/AIDS. This study was carried out between February and June 2014, to ascertain the awareness and response of University students to HIV/AIDS Voluntary Counseling and Testing. A total of four hundred and sixty four students were interviewed with the aid of structured questionnaire. Data were analyzed for simple descriptive (mean and mode) and inferential (Chi square) statistics using the Statistical Package for Social Sciences (SPSS) for Windows. Results revealed that 52.2% of the respondents were females while 47.8% were males. Most respondents were between ages 20-24 (70.5%) and single (90.8%). A greater number of the respondents (83%) disagreed with the notion that HIV/AIDS can be contacted by sharing toilet facilities while 91% and 94.4% identified unprotected sex and the re-use of sharp objects used by HIV/AIDS patients as means of contracting HIV. The study on the level of awareness of HIV/AIDS revealed an appreciable level of awareness (91.1%). A large number of the respondents (77.6%) claimed that although they were aware of the VCT centre of the University but had never visited it. The study showed that there existed a significant relationship (p < 0.05) between the respondents’ age, sex, marital status, sexual information and perception, knowledge, attitudes and awareness of HIV/AIDS. This study recommends that social network platforms, ‘edu-tainment’, role models stories, discussion forums, behavior modifications, radio and drama would bring a decline in the transmission of the Virus within the University campus and increase students’ patronage of the VCT centre of the University.
The Hydrophobicity of Lignocellulosic Fiber Network Can Be Enhanced with Suberin Fatty Acids

Suberin fatty acids were extracted from outer bark of Silver birch (Betula pendula Roth.) using an isopropanolic sodium hydroxide solution. Laboratory sheets composed of lignocellulosic fiber networks were prepared from unbleached and unrefined softwood kraft pulp and further impregnated with suberin fatty acid monomers and cured with maleic anhydride in ethanol solution. The treatment resulted in hydrophobic surfaces, in which the contact angles remained over 120 degrees during the entire measurement. The fiber network also retained its water vapor permeability and enhanced fiber–fiber bonding resulted in improved tensile strength of the sheets. Scanning electron microscopy (SEM) images revealed that the curing agent, together with suberin fatty acids, was evenly distributed on the fiber surfaces and smoothing occurred over the wrinkled microfibrillar structure. High concentrations of the curing agent resulted in globular structures containing betulinol derivates as revealed with time-of-flight secondary ion mass spectrometry (ToF-SIMS). Also, the larger amount of suberin fatty acid monomers slightly impaired the optical properties of sheets.
ANTI-ULCEROGENIC EFFECT OF GINGER (rhizome of Zingiber officinale Roscoe) ON CYSTEMINE INDUCED DUODENAL ULCER IN RATS

Ginger (rhizome of Zingiber officinale Roscoe) is a widespread herbal medicine mainly used for the treatment of gastrointestinal (GI) disorders including: dyspepsia, nausea and diarrhea. Aromatic, spasmolytic, carminative and absorbent properties of ginger suggest that it has direct effects on the GI tract and anti-ulcerogenic potential. In the present study, the effects of this herbal remedy on an acute model of experimental duodenal ulcer induced by cysteamine was evaluated. Hydroalcoholic extract ofgginger with doses of 100, 350, 700 mg/kg, ranitidine (50 mg/kg), sucralfate (500 mg/kg) and 5 ml/kg of vehicle were administered orally (p.o.) to separate groups of male Wistar rats. Other groups received vehicle (5 ml/kg), extract (300 mg/kg) and ranitidine (50 mg/kg) intraperitoneally (i.p.). After ulcer induction, the number, scoring, area and finally ulcer index were assessed for each duodenum. Administration of extract by i.p. or at chronic doses (350 mg/kg) and ranitidine (p.o. and i.p.) resulted in significant reduction in mucosal damage for the entire ulcer factors which were assessed. Larger doses of extract given p.o. (350 and 700 mg/kg) were effective to reduce both the ulcer area and index but the lowest dose of extract (100 mg/kg) was not effective. Taken together, we conclude that ginger hydroalcoholic extract was effective to protect against duodenal ulceration and for i.p. injection as well as chronic administration, the efficacy was comparable with ranitidine as reference drug.
Foreword

It is my privilege to introduce these two special issues of The Yale Journal of Biology and Medicine containing selected papers presented at the VlIIth International Symposium on Psychotherapy of Schizophrenia: New Approaches to Psychosocial Intervention. The manuscripts published here were selected first by the Editorial and Program Committee, consisting of Drs. Lyman Wynne (Rochester, New York), Daniel P. Schwartz (Stockbridge, Massachusetts), Ira Levine (New Haven, Connecticut), John Gunderson (Boston, Massachusetts), Stephen Fleck (New Haven, Connecticut) and Drs. Yrjo Alanen (Turku, Finland), Jarl Jorstad (Oslo, Norway), Helm Stierlin (Heidelberg, West Germany), Pekka Tienari (Oulu, Finland), Dr. Endre Ugelstad (Oslo), and then by the Editorial Board of the Journal. We are greatly indebted to the Editor of this prestigious journal and to his colleagues for making this publication possible. The Symposium, furthermore, could not have taken place without the additional work of a local arrangements committee: Ms. Mady Chalk, Dr. Charles W. Gardner, Drs. Theodore Lidz, Stan Possick, Robert Rosenheck, and Mr. Lawrence Berger, as well as Dr. Levine and myself. Noteworthy is the fact that this was the first such symposium to be held in the United States at a time, as noted by Dr. Theodore Lidz in his keynote address, when interest in the psychotherapy of schizophrenics is rather low in the United States compared with Europe, a reversal in orientation and research in the two areas over the last quarter-century. Nevertheless, the participation and enthusiasm of the audience of over 300 colleagues, in addition to those involved in the program, conveyed anything but a sense of stagnation or pessimism about the topic. A list of all program contributors is presented at the end of the second special issue. One of the most important features of the conference was five case presentations with a panel of discussants, including one simulated family therapy session. These excellent and well-received presentations are not included in this volume for various reasons, including confidentiality and the severe space limitation imposed by our limited resources. The papers in this volume are arranged in an order that approximates a progression from theoretical and epidemiological topics in the first issue to problems in psychopathological developments and research, to treatment issues and program evaluations, ranging from dyadic psychotherapy to family and group treatments, and finally to a proposal for "global therapy," an action research report from Turku, Finland, representing probably the most comprehensive project with ongoing program evaluation in this field anywhere. It has been my honor to coordinate the work of arranging the symposium program and of this publication. Not only I but the readers are indebted to the committees mentioned above, who deserve our thanks, as do all the participants in the symposium, presenters and audience alike, for this successful event.
Deregulation of the Histone Lysine-Specific Demethylase 1 Is Involved in Human Hepatocellular Carcinoma

Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer and is a leading cause of cancer-related death worldwide. Given that the standard-of-care for advanced liver cancer is limited, there is an urgent need to develop a novel molecular targeted therapy to improve therapeutic outcomes for HCC. In order to tackle this issue, we conducted functional analysis of the histone lysine-specific demethylase (LSD1) to explore the possibility that this enzyme acts as a therapeutic target in HCC. According to immunohistochemical analysis, 232 of 303 (77%) HCC cases showed positive staining of LSD1 protein, and its expression was correlated with several clinicopathological characteristics, such as female gender, AFP (alpha-fetoprotein) levels, and HCV (hepatitis C virus) infectious. The survival curves for HCC using the Kaplan–Meier method and the log-rank test indicate that positive LSD1 protein expression was significantly associated with decreased rates of overall survival (OS) and disease-free survival (DFS); the multivariate analysis indicates that LSD1 expression was an independent prognostic factor for both OS and DFS in patients with HCC. In addition, knockout of LSD1 using the CRISPR/Cas9 system showed a significantly lower number of colony formation units (CFUs) and growth rate in both SNU-423 and SNU-475 HCC cell lines compared to the corresponding control cells. Moreover, LSD1 knockout decreased cells in S phase of SNU-423 and SNU-475 cells with increased levels of H3K4me1/2 and H3K9me1/2. Finally, we identified the signaling pathways regulated by LSD1 in HCC, including the retinoic acid (RA) pathway. Our findings imply that deregulation of LSD1 can be involved in HCC; further studies may explore the usefulness of LSD1 as a therapeutic target of HCC.
Increased monohexosylceramide levels in the serum of established rheumatoid arthritis patients.

OBJECTIVES To identify serum sphingolipids that could act as candidate biomarkers in RA. METHODS We performed lipidomic analyses in the serum of 82 participants: 19 established RA patients, 18 untreated early RA patients, 13 untreated early arthritis patients not fulfilling the classification criteria for RA, 12 established SpA patients and 20 controls. We compared the lipid levels from the different patient groups with the control group through multiple-regression analyses controlling for age at diagnosis, gender and medication (cDMARDs and corticoids). RESULTS Established RA patients had significantly increased levels of sphingosine, monohexosylceramide and ceramide compared with controls, when controlling for age and gender. Monohexosylceramide levels remained significantly increased when additionally controlling for medication. On the contrary, SpA patients had significantly decreased levels of ceramide, in both analyses. CONCLUSION We observed a detectable increase in the levels of certain sphingolipids in the serum of established RA patients when compared with controls, in line with previous observations in the synovial fluid. Such findings provide further evidence that sphingolipids may play a key role in the pathophysiology of RA.
Advances In Research Of Spreading Through Air Spaces And The Effects On The Prognosis Of Lung Cancer

Abstract The concept of spread through air spaces (STAS) has been described as a new form of invasion in the lung in the 2015 WHO classiﬁcation of Lung Tumors, namely invasion through alveolar spaces. STAS is a prognostic factor independent of growth pattern and tumor stage, and it is also an independent risk factor for unfavorable prognosis of stage I lung adenocarcinoma (ADC) and stage I lung squamous cell carcinoma (SCC). The pathological characteristics are different between ADC and SCC. STAS is not reported as routine, so setting a unified pathological reading standard, and hunting for STAS as a regular reading process is urgently advocated. We write this review to investigate the research progress of STAS and its effects on the prognosis of lung cancer.
Stroke risk following implantation of current generation centrifugal flow left ventricular assist devices

Stroke remains a significant complication of left ventricular assist device (LVAD) therapy. We performed a single‐center retrospective study evaluating patients undergoing first‐time HeartWare HVAD (Medtronic Inc) or HeartMate 3 (Abbott Inc) implantation from September 2009‐February 2018.
Age-Related Temporal Processing Deficits in Word Segments in Adult Cochlear-Implant Users

Aging may limit speech understanding outcomes in cochlear-implant (CI) users. Here, we examined age-related declines in auditory temporal processing as a potential mechanism that underlies speech understanding deficits associated with aging in CI users. Auditory temporal processing was assessed with a categorization task for the words dish and ditch (i.e., identify each token as the word dish or ditch) on a continuum of speech tokens with varying silence duration (0 to 60 ms) prior to the final fricative. In Experiments 1 and 2, younger CI (YCI), middle-aged CI (MCI), and older CI (OCI) users participated in the categorization task across a range of presentation levels (25 to 85 dB). Relative to YCI, OCI required longer silence durations to identify ditch and exhibited reduced ability to distinguish the words dish and ditch (shallower slopes in the categorization function). Critically, we observed age-related performance differences only at higher presentation levels. This contrasted with findings from normal-hearing listeners in Experiment 3 that demonstrated age-related performance differences independent of presentation level. In summary, aging in CI users appears to degrade the ability to utilize brief temporal cues in word identification, particularly at high levels. Age-specific CI programming may potentially improve clinical outcomes for speech understanding performance by older CI listeners.
Cohort Profile: The Dutch Perined-Lifelines birth cohort

Background Maternal nutrition status (e.g. dietary/nutrient intake) during pregnancy has been associated with pregnancy outcomes including birth weight, infant survival and metabolic health of the offspring during later life. During the past few years, maternal dietary intake, at least three months before conception, has been shown to affect pregnancy outcomes also. However, literature investigating this link is still scarce. The studies that have looked at preconception dietary intake in relation to pregnancy outcome were either animal studies, had small sample sizes or focused on only selected macronutrient intake rather than complete (macro)nutrient composition or dietary intakes (e.g. food groups). Therefore, we aim to investigate the association between preconception diet and pregnancy outcomes in a linked birth cohort. The main objective of this manuscript is to describe the methodology of establishing this birth cohort and to describe both the characteristics of the study population included as well as the representativeness in terms of dietary intake. Methods We created the birth cohort by linking two existing databases; a large population-based cohort study in the Netherlands (The Lifelines Cohort study) and the Dutch national birth registry (Perined), through a ‘trusted third party’. The birth cohort contains information on maternal dietary intake during preconception as well as pregnancy outcomes. Results and discussion In the Lifelines Cohort study, 3,418 pregnancies were available for linking with Perined. In total, 2,368 pregnancies (86.9%) were linked with Perined, resulting in the birth cohort. With this linked cohort we are able to provide insights on the associations between dietary intake before conception and pregnancy outcomes. Such data could potentially improve nutritional care for women of childbearing age. Lifestyle changes in the period preceding pregnancy may be most effective in improving pregnancy outcomes. A focus on this window of opportunity may provide both sufficient time, as well as a period when women are potentially motivated to adopt health optimizing behaviours.
Food Sources of Potassium in the Average Polish Diet

The aim of this study was to identify the food sources of potassium in the average Polish diet based on the data from the 2016 Household Budget Survey conducted on the representative sample of the Polish population (36,886 households, n = 99,230). This survey is organized by the Central Statistical Office and is related to the expenditures, quantitative consumption and revenues in households. We analyzed 91 sub-groups (i.e., milk, red meat) from 13 food categories (i.e., milk and dairy products, meat and products). Our findings indicated that the daily supply of potassium in the average Polish diet was 2617.9 mg, which meant covering the average allowance in 83%. Vegetables provided 32.5% of potassium, of which potatoes accounted for 16.2% of supply, and other vegetables for 16.2%. Tomatoes as well as other vegetables and mushrooms provided a total of 8.2% of potassium among vegetables. The next position was taken by the meat and meat products category (17.7%), with the largest share of meat products (6.7%) and red meat (5.2%). Cereal products supplied 16.64% of potassium, of which bread, rolls and bread products (12.2%) were of the greatest importance. Milk and dairy products turned out to be the fourth product category as a source of potassium (11.9%), with the highest share of milk (6.8%) and yoghurts and milk drinks (3.9%).
In vivo ultrasound thermal ablation control using echo decorrelation imaging in rabbit liver and VX2 tumor

The utility of echo decorrelation imaging feedback for real-time control of in vivo ultrasound thermal ablation was assessed in rabbit liver with VX2 tumor. High-intensity focused ultrasound (HIFU) and unfocused (bulk) ablation were performed using 5 MHz linear image-ablate arrays. Treatments comprised up to nine lower-power sonications, followed by up to nine higher-power sonications, ceasing when the average cumulative echo decorrelation within a control region of interest exceeded a predefined threshold (− 2.3, log10-scaled echo decorrelation per millisecond, corresponding to 90% specificity for tumor ablation prediction in previous in vivo experiments). This threshold was exceeded in all cases for both HIFU (N = 12) and bulk (N = 8) ablation. Controlled HIFU trials achieved a significantly higher average ablation rate compared to comparable ablation trials without image-based control, reported previously. Both controlled HIFU and bulk ablation trials required significantly less treatment time than these previous uncontrolled trials. Prediction of local liver and VX2 tumor ablation using echo decorrelation was tested using receiver operator characteristic curve analysis, showing prediction capability statistically equivalent to uncontrolled trials. Compared to uncontrolled trials, controlled trials resulted in smaller thermal ablation regions and higher contrast between echo decorrelation in treated vs. untreated regions. These results indicate that control using echo decorrelation imaging may reduce treatment duration and increase treatment reliability for in vivo thermal ablation.
Impact of Evaporation Models and Droplet Size on Auto-ignition and Lift-off Height in a Spray Jet Flame

ABSTRACT In the current work, the jet spray flame reflecting an experimental configuration of a piloted spray burner with a vitiated hot co-flow is modeled using large eddy simulation (LES). We consider a diluted polydisperse spray, which evaporates and diffuses from a fuel-rich spray core, mixes with an oxidizer and eventually auto-ignites. The objective of the present study is to assess an influence of evaporation models and mean droplet diameter on the combustion process in a lifted flame, starting from an auto-ignition up to the flame stabilization. Three evaporation models are involved, i.e., (i) “D2 law”, (ii) infinite conductivity model with Stefan flow effect, and (iii) infinite conductivity non-equilibrium evaporation model based on a Langmuir-Knudsen law. An in-house high-order numerical code was used to carry out the computations. The continuous gas phase is modeled in the Eulerian coordinate system while the spray droplets are tracked in space in the Lagrangian manner. The obtained results show that in a stable combustion regime a flame size and liftoff height only slightly depend on evaporation model. However, in general, it is observed that the spray size can affect the flame structure to a much larger extent. On the other hand, for bigger droplets differences in initial size distribution cause only small flame movement downstream or upstream toward the fuel nozzle. For auto-ignition and initial flame development phase it is observed that both the droplets size and evaporation model affect the obtained results significantly.
Association of Night Eating with Depression and Depressive Symptoms in Korean Women

This study examined the associations of night eating with depression and depressive symptoms in Korean adults. The study used a nationally representative sample of 31,690 Korean adults (≥19 years old) from the Korea National Health and Nutrition Examination Survey from 2008 to 2013. The participants were divided into two groups based on status of night eating: night eaters (consuming ≥25% of total daily energy intake between 21:00 and 06:00) and non-night eaters. Depression was defined based on diagnosis by a doctor, whereas depressive symptoms were defined as feelings of sadness or desperation for more than two weeks in the last one year. Multivariable logistic regression analyses were performed to examine the relationship between night eating and odds of depression and depressive symptoms after controlling for age, education, income, marital status, drinking, smoking, day of recalled intake, physical activity, body mass index, menopausal status (women only), total energy intake, and sleep duration. A total of 14.3% of Korean adults were night eaters. Night eaters were more likely to be men, young, less educated, single, drinkers, current smokers, and not employed (all ps < 0.05). In women, night eaters had higher odds of depression (adjusted odds ratio [AOR], 1.33; 95% confidence interval [CI], 1.02–1.75; p for trend = 0.0389) and depressive symptoms (AOR, 1.20; 95% CI, 1.01–1.41; p for trend = 0.0382) compared with non-night eaters. However, no associations of night eating with depression and depressive symptoms were found in men. Night eaters had higher odds of depression and depressive symptoms only in Korean women. Future studies are warranted to elucidate the underlying psychological and behavioral mechanisms that in turn may shed light on the factors influencing both night eating and odds of depression and depressive symptoms.