Miracle-dz/UniFAR-FTUs huggingface dataset:
A Retrospective Comparison of Clinical Efficacy between Multimodal Analgesia and Patient-Controlled Epidural Analgesia in Patients Undergoing Total Knee Arthroplasty

Background and Objectives: Adequate pain management during early rehabilitation is mandatory for improving the outcomes of patients undergoing total knee arthroplasty (TKA). Conventional pain management, mainly comprising opioids and epidural analgesia, may result in certain adverse effects such as dizziness, nausea, and motor blockade. We proposed a multimodal analgesic (MA) strategy involving the use of peripheral nerve block (NB), periarticular injection (PAI), and intravenous patient-controlled analgesia (IVPCA). This study compared the clinical efficacy and adverse effects of the proposed MA strategy and patient-controlled epidural analgesia (PCEA). Materials and Methods: We enrolled 118 patients who underwent TKA under spinal anesthesia. The patients followed either the MA protocol or received PCEA after surgery. The analgesic effect was examined using a numerical rating scale (NRS). The adverse effects experienced by the patients were recorded. Results: A lower proportion of patients in the MA group experienced motor blockade (6.45% vs. 22.98%) compared to those in the PCEA group on the first postoperative day. Furthermore, a lower proportion of patients in the MA group experienced numbness (18.52% vs. 43.33%) than those in the PCEA group on the first postoperative day. Conclusions: The MA strategy can be recommended for reducing the occurrence of motor blockade and numbness in patients following TKA. Therefore, the MA strategy ensures early rehabilitation while maintaining adequate pain relief.
Cr-V oxides from the Rampura Agucha Pb-Zn-(Ag) deposit, Rajasthan, India

Two new compositional varieties of rme oxide minerals have been studied by ore microscopy and electron-microprobe analysis in samples from the high-grade metamorphic, stratiform Rampura Agucha Pb--Zn{Ag) deposit, Rajasthan, IndiaWe have established the presence of a Cr-V-Fe spinel and a Cr-V rhombohedral oxide. The compositions of the two minerals, Vs.s-1.15Cr9. 6a_1. 15Fej. 6_n. 67Mn6.12+. y.Mgo. A4zrzno.os-o.ozOa a d V1.111. 6Crs. 36_4. sFe6. 62_n. 17O3, respectively, differ from known end-members because of considerable substitution of Cr for V. Similar solid-solution series of spinels in the system FeCrrO. FeVrOo MnCrrOa MnV2O4, such as manganochromite, worelainenite and coulsonite, as well as relatively pure karelianite and eskolaite, have been reported from several high-grade metamorphic deposis and areas. The rare V-oxide schreyerite, V2Ti3O9, also occurs as exsolution lamellae in rutile at Rampura Agucha. These unusual compositions are arcributed to locally high concentrations of V in the precursor sediments; they further underscore the isochemical nature of regional metamorphism of the orebody.
Integrative NGS testing reveals clonal dynamics of adverse genomic defects contributing to a natural progression in treatment‐naïve CLL patients

Large‐scale next‐generation sequencing (NGS) studies revealed extensive genetic heterogeneity, driving a highly variable clinical course of chronic lymphocytic leukaemia (CLL). The evolution of subclonal populations contributes to diverse therapy responses and disease refractoriness. Besides, the dynamics and impact of subpopulations before therapy initiation are not well understood. We examined changes in genomic defects in serial samples of 100 untreated CLL patients, spanning from indolent to aggressive disease. A comprehensive NGS panel LYNX, which provides targeted mutational analysis and genome‐wide chromosomal defect assessment, was employed. We observed dynamic changes in the composition and/or proportion of genomic aberrations in most patients (62%). Clonal evolution of gene variants prevailed over the chromosomal alterations. Unsupervised clustering based on aberration dynamics revealed four groups of patients with different clinical behaviour. An adverse cluster was associated with fast progression and early therapy need, characterized by the expansion of TP53 defects, ATM mutations, and 18p− alongside dynamic SF3B1 mutations. Our results show that clonal evolution is active even without therapy pressure and that repeated genetic testing can be clinically relevant during long‐term patient monitoring. Moreover, integrative NGS testing contributes to the consolidated evaluation of results and accurate assessment of individual patient prognosis.
The effectiveness of blinatumomab in clearing measurable residual disease in pediatric B‐cell acute lymphoblastic leukemia patients detected by next‐generation sequencing

Blinatumomab improved survival outcomes in B‐cell acute lymphoblastic leukemia (B‐ALL) patients with measurable residual disease (MRD) <10−4. However, data on blinatumomab clearing MRD with high sensitivity of 10−6 remain scarce. This study evaluates the effectiveness of blinatumomab in eradicating extremely low level (up to <10−6) of MRD, as detected by next‐generation sequencing (NGS), in children with B‐ALL.
INTERTEXTUALITY AND INTERDISCURSIVITY IN POST-COLONIAL LANGUAGE POLICIES IN KENYA

Addressing the intricate challenges within the realm of language planning and policy involves establishing meaningful connections between language policy texts, discourse, and actual language practices. Moreover, navigating connections across diverse domains, contexts, levels, layers, and scales presents a formidable challenge. Therefore, this study endeavours to unravel intertextual connections as a means of comprehending language-policy texts in the Kenyan context. Focusing on post-colonial language policies in Kenya, this paper explores intertextuality and interdiscursivity. Employing Fairclough's (1992) Critical Discourse approach, this analysis explores how language policy documents undergo decontextualization from prior discourses (intertextuality) and examine their correlation with different generic chains (interdiscursivity). The study employs a qualitative research design, specifically historical and documentary analysis. The study's findings reveal that post-colonial language policies exhibit links to both pre-colonial and current policy documents, showcasing vertical and horizontal intertextuality. Additionally, these policies are linked to a myriad of past and present discourses, such as those related to culture and diversity (interdiscursivity). Notably, the analysis of intertextuality and interdiscursive discourse reveals revisions to language policy and tracks the shifts in discourses surrounding this policy over time. In conclusion, this study emphasises that the meaningful interpretation of intertextuality and interdiscursivity renders language policy texts significant. It is anticipated that this research will shed light on understanding language policy through the lens of intertextuality and interdiscursivity, contributing to a more comprehensive perspective on language policy dynamics. Article visualizations:
Defective ZrSe2: a promising candidate for spintronics applications

The current study presents the electronic and magnetic properties of monolayer ZrSe2 nanoribbons. The impact of various point defects in the form of Zr or Se vacancies, and their combinations, on the nanoribbon electronic and magnetic properties are investigated using density functional theory calculations in hydrogen-terminated zigzag and armchair ZrSe2 nanoribbons. Although pristine ZrSe2 is non-magnetic, all the defective ZrSe2 structures exhibit ferromagnetic behavior. Our calculated results also show that the Zr and Se vacancy defects alter the total spin magnetic moment with D6Se, leading to a significant amount of 6.34 µB in the zigzag nanoribbon, while the largest magnetic moment of 5.52 µB is induced by D2Se−2 in the armchair structure, with the spin density predominantly distributed around the Zr atoms near the defect sites. Further, the impact of defects on the performance of the ZrSe2 nanoribbon-based devices is investigated. Our carrier transport calculations reveal spin-polarized current-voltage characteristics for both the zigzag and armchair devices, revealing negative differential resistance (NDR) feature. Moreover, the current level in the zigzag-based nanoribbon devices is ∼10 times higher than the armchair devices, while the peak-to-valley ratio is more pronounced in the armchair-based nanoribbon devices. It is also noted that defects increase the current level in the zigzag devices while they lead to multiple NDR peaks with rather negligible change in the current level in the armchair devices. Our results on the defective ZrSe2 structures, as opposed to the pristine ones that are previously studied, provide insight into ZrSe2 material and device properties as a promising nanomaterial for spintronics applications and can be considered as practical guidance to experimental work.
Efficacy and safety of fruquintinib dose‐escalation strategy for elderly patients with refractory metastatic colorectal cancer: A single‐arm, multicenter, phase II study

Fruquintinib has demonstrated significant improvement in overall survival (OS) among previously treated metastatic colorectal cancer (mCRC) patients. However, the utilization of fruquintinib has been constrained by various toxicities, such as hand‐foot skin reaction (HFSR) and hypertension, particularly in elderly patients with reduced tolerance to the standard dosage. This study aims to investigate the efficacy and safety of fruquintinib dose‐escalation strategy for elderly refractory mCRC patients.
Basement structural architecture and hydrocarbon conduit potential of polygonal faults in the Cooper‐Eromanga Basin, Australia

A thorough and complete understanding of the structural geology and evolution of the Cooper‐Eromanga Basin has been hampered by low‐resolution seismic data that becomes particularly difficult to interpret below the thick Permian coal measures. As a result, researchers are tentative to interpret the basement fault architecture within the basin, which is largely undefined. To provide a better understanding of the basement fault geometry, all available two‐dimensional seismic lines together with 12 three‐dimensional seismic surveys were structurally interpreted with assistance from seismic attribute analysis. The Upper Cretaceous Cadna‐owie Formation and top Permian reflectors were analysed using a common seismic attribute technique (incoherency) that was used to infer the presence of faults that may have otherwise been overlooked. Detailed basement fault maps for each seismic survey were constructed and used in conjunction with two‐dimensional seismic data interpretation to produce a regional basement fault map. Large north‐northeast–south‐southwest‐striking sinistral strike–slip faults were identified within the Patchawarra Trough appearing to splay from the main northeast–southwest‐striking ridge. These sinistral north‐northeast–south‐southwest‐striking faults, together with field‐scale southeast–northwest‐striking dextral strike–slip faults, are optimally oriented to have potentially developed as a conjugated fault set under a south‐southeast–north‐northwest‐oriented strike–slip stress regime. Geomechanical modelling for a regionally extensive system of Cretaceous polygonal faults was performed to calculate the Leakage Factor and Dilation Tendency of individual faults. Faults that extend into Lower Cretaceous oil‐rich reservoirs with strikes of between 060°N and 140°N and a high to near‐vertical dip angle were identified to most likely be acting as conduits for the tertiary migration of hydrocarbons from known Lower Cretaceous hydrocarbon reservoirs into shallow Cretaceous sediments. This research provides valuable information on the regional basement fault architecture and a more detailed exploration target for the Cooper‐Eromanga Basin, which were previously not available in literature.
The Status of Didactic Models for Heritage Education: A Systematic Review

Heritage education is very important because it implies a holistic and transdisciplinary approach, where teachers must use resources and educational proposals that promote the conservation, appreciation, and care of heritage. The objective of this study is to analyze heritage education from a global perspective to identify didactic models, areas of educational action, categories, and typologies used in teaching and learning processes. A systematic review of the literature is proposed using the PRISMA methodology in three multidisciplinary databases by carrying out an exhaustive search with inclusion and exclusion criteria. The results highlight that teachers develop learning experiences focused on didactic models with pedagogical intervention in the classroom with formal action, focusing mainly on intangible heritage related to festive acts and rituals; so, they only achieve identity levels and do not reach the heritage levels necessary to create a legacy and promote the appreciation of cultural heritage. The use of digital educational strategies and resources is required to integrate real and simulated spaces with new educational and didactic approaches using virtual technologies. Consequently, this study implies that teachers need to develop digital skills to achieve more effective and meaningful heritage education.
Performance Analysis of Mapping Functions and Mean Temperature Equations for GNSS Precipitable Water Vapor in the Korean Peninsula

The performance of up-to-date mapping functions and various mean temperature equations were analyzed to derive optimal mapping function and mean temperature equation when GNSS precipitable water vapor (PWV) was investigated in the Korean Peninsula. Bernese GNSS Software 5.2, which can perform high precision GNSS data processing, was used for accurate analysis, and zenith total delay (ZTD) required to calculate PWV was estimated via the Precise Point Positioning (PPP) method. GNSS, radiosonde, and meteorological data from 2009 to 2014 were acquired from Sokcho Observatory and used. ZTDs estimated by applying the global mapping function (GMF) and Vienna mapping function 1 (VMF1) were compared with each other in order to evaluate the performance of the mapping functions. To assess the performance of mean temperature equations, GNSS PWV was calculated by using six mean temperature equations and a difference with radiosonde PWV was investigated. Conclusively, accuracy of data processing was improved more when using VMF1 than using GMF. A mean temperature equation proposed by Wu (2003) had the smallest difference with that in the radiosonde in the analysis including all seasons. In summer, a mean temperature equation proposed by Song & Grejner-Brzezinska (2009) had the closest results with that of radiosonde. In winter, a mean temperature equation proposed by Song (2009) showed the closest results with that of radiosonde.
The Influence of Social Relations on Entrepreneurial Orientation of Rural Entrepreneurs: With Special Reference to Small and Medium Scale Manufacturing Enterprises in Kurunegala District, Sri Lanka

Entrepreneurship is a driving force behind worldwide economic growth in a variety of areas. This trend is exemplified by a growing population of rural entrepreneurs involved in small and medium-scale manufacturing firms, which is causing substantial transformations in labor force dynamics. In this context, this research assesses the impact of social relations on the entrepreneurial orientation of rural entrepreneurs in Kurunegala district, Sri Lanka. This comprehensive analysis takes a holistic approach, combining inductive and deductive research approaches and utilizing a dual quantitative and qualitative data collection strategy. The research findings highlight the pivotal role of "social relations" as a spatial factor, demonstrating a moderate positive correlation with entrepreneurial orientation, accounting for 30.4% of the variation in the dependent variable. Furthermore, the study emphasizes the importance of humanizing neighborly ties, emphasizing mental well-being, increasing life happiness, participating in social work, and cultivating a culture of sharing and caring. Qualitative research reveals the intangible, hidden aspects of the entrepreneurial scene. As a result, this study advises for the region's entrepreneurial orientation to be reinforced by creating strong social links and implementing future-oriented industrial planning. More research is needed to uncover the unknown features of the link between independent and dependent variables. Such investigation promises to reveal more about the dynamics of entrepreneurial orientation in the Kurunegala district. Finally, this research endeavor has the potential to stimulate the growth of small and medium-scale manufacturing firms in rural areas, thus considerably contributing to the region's overall economic development.
Design of alginate microsphere formulation as a probiotics carrier

The process of obtaining alginate microspheres (AMs) by emulsification method was optimized by applying statistical analysis software. Ten batches of microspheres were prepared using the fractional plan 3 (K-p) . AMs were obtained with two different methods: an ultrasonic homogenization (UH) process and a rotor-stator mechanical homogenization (MH). The amount of a cross-linking agent (CaCl 2 ), calcium chloride rate addition, and the sonication amplitude (UH) or the speed of rotor rotation (MH) were selected as formulation variables. All the batches were evaluated in terms of stability and size of the alginate microspheres. Approximation profiles were developed. As a result of the conducted research, stable alginate microspheres with sizes ranging from 10 to 30 micrometres were obtained. The obtained results showed that the quality of AMs was mainly affected by the concentration and the rate of calcium chloride addition into the system. Therefore, the role of calcium ions in the mechanisms of shell structuring was discussed. Lactobacillus casei bacteria were encapsulated into the batches found to be optimum. The high encapsulation efficiency (EE) of the bacteria (72-94%) depending on the form) and their viability over time were obtained. The model developed in the study can be effectively utilized to achieve the AMs formulations
Microplastics cause hepatotoxicity in diabetic mice by disrupting glucolipid metabolism via PP2A/AMPK/HNF4A and promoting fibrosis via the Wnt/β‐catenin pathway

In recent years, microplastics (MPs) have gained significant attention as a persistent environmental pollutant resulting from the decomposition of plastics, leading to their accumulation in the human body. The liver, particularly of individuals with type 2 diabetes mellitus (T2DM), is known to be more susceptible to the adverse effects of environmental pollutants. Therefore, to investigate the potential impact of MPs on the liver of diabetic mice and elucidate the underlying toxicological mechanisms, we exposed db/db mice to 0.5 μm MPs for 3 months. Our results revealed that MPs exposure resulted in several harmful effects, including decreased body weight, disruption of liver structure and function, elevated blood glucose levels, impaired glucose tolerance, and increased glycogen accumulation in the hepatic tissue of the mice. Furthermore, MPs exposure was found to promote hepatic gluconeogenesis by perturbing the PP2A/AMPK/HNF4A signaling pathway. In addition, MPs disrupt redox balance, leading to oxidative damage in the liver. This exposure also disrupted hepatic lipid metabolism, stimulating lipid synthesis while inhibiting catabolism, ultimately resulting in the development of fatty liver. Moreover, MPs were found to induce liver fibrosis by activating the Wnt/β‐catenin signaling pathway. Furthermore, MPs influenced adaptive thermogenesis in brown fat by modulating the expression of uncoupling protein 1 (UCP1) and genes associated with mitochondrial oxidative respiration thermogenesis in brown fat. In conclusion, our study demonstrates that MPs induce oxidative damage in the liver, disturb glucose and lipid metabolism, promote hepatic fibrosis, and influence adaptive thermogenesis in brown fat in diabetic mice. These findings underscore the potential adverse effects of MPs on liver health in individuals with T2DM and highlight the importance of further research in this area.
The Preserflo MicroShunt Affects Microvascular Flow Density in Optical Coherence Tomography Angiography

Intraocular pressure (IOP) lowering surgery has been shown to alter microvascular density in glaucoma patients. The aim of this study is to report changes in retinal flow density (FD) over the course of treatment with the Preserflo MicroShunt, using optical coherence tomography angiography (OCTA). 34 eyes from 34 patients who underwent Preserflo MicroShunt implantation were prospectively enrolled in this study. OCTA imaging was conducted at the superficial (SCP), deep (DCP) and radial peripapillary plexus (RPC) levels. The progression of FD and IOP was assessed at different time points from baseline to six months postoperatively for the entire patient population, as well as disease severity subgroups. The Preserflo MicroShunt achieved a significant reduction in IOP over the course of six months (median: 8 mmHg; p < 0.01). FD values of the SCP and DCP did not show significant fluctuations, even after adjusting for disease severity. FD of the RPC decreased significantly over the course of six months postoperatively from 42.31 at baseline to 39.59 at six months postoperatively (p < 0.01). The decrease in peripapillary FD was strongest in patients with advanced glaucoma (median: −3.58). These observations hint towards dysfunctional autoregulatory mechanisms in capillaries surrounding the optic nerve head in advanced glaucoma. In comparison, the microvascular structure of the macula appeared more resilient to changes in IOP.
Exploiting Morphophysiological Traits for Yield Improvement in Upland Cotton under Salt Stress

ABSTRACT The increased land salinization threatens land productivity, food security, and economic losses. The study used a comprehensive set of morpho-physiological, biochemical, and fiber quality parameters to examine the genetic variability of 24 cotton genotypes against 15 dSm-1 salt stress. The general linear model (GLM) effect revealed significant effects of salinity for studied accessions except for lint percentage and fiber strength. The genotype × treatment effects were also significant for all studied traits, while non-significant effects were observed for seed number per boll (SNB), potassium to sodium ratio (K+/Na+), K+, peroxidase (POD), and catalase (CAT). A notable reduction for all traits was observed except for fiber fineness, superoxide (SOD), CAT, POD, carotenoid contents, and hydrogen peroxide (H2O2), which were increased under saline conditions. Based on multivariate analyses, hybrids viz. MS-71× KAHKASHAN, followed by MS-71× CRS-2007 and NS-131× CRS-2007, performed well under both normal stressed conditions. Moreover, biochemical and agronomical traits in PCA validate that the MS-71× KAHKASHAN is the most desirable genotype under both conditions. Better hybrid performance under normal and 15 dSm-1 salt stress conditions supports the hybrid adaptability under salinity stress environments. The outcome would assist breeders in developing salt-tolerant cotton varieties under climate change scenarios.