Miracle-dz/UniFAR-FTUs huggingface dataset:
γδ T Cells: A Game Changer in the Future of Hepatocellular Carcinoma Immunotherapy

Hepatocellular carcinoma (HCC) remains a global health challenge with limited treatment options and a poor prognosis for advanced-stage patients. Recent advancements in cancer immunotherapy have generated significant interest in exploring novel approaches to combat HCC. One such approach involves the unique and versatile subset of T cells known as γδ T cells. γδ T cells represent a distinct subset of T lymphocytes that differ from conventional αβ T cells in terms of antigen recognition and effector functions. They play a crucial role in immunosurveillance against various malignancies, including HCC. Recent studies have demonstrated that γδ T cells can directly recognize and target HCC cells, making them an attractive candidate for immunotherapy. In this article, we aimed to explore the role exerted by γδ T cells in the context of HCC. We investigate strategies designed to maximize the therapeutic effectiveness of these cells and examine the challenges and opportunities inherent in applying these research findings to clinical practice. The potential to bring about a revolutionary shift in HCC immunotherapy by capitalizing on the unique attributes of γδ T cells offers considerable promise for enhancing patient outcomes, warranting further investigation.
Adoption of IFRS Sustainability Standards (IFRS-S) In Brazil: Contributions to The Development of Climate-Related Disclosure Indicators

Objective: The main objective of this article is to develop climate-related disclosure indicators that are applicable to the Brazilian business context. Method: The Delphi method was used to achieve this objective, involving several experts representing various user groups that influence the formulation of accounting standards in Brazil. The Delphi method is a decision-making tool that establishes an effective communication process, facilitating the resolution of complex problems. Result and Conclution: As a result, 40 climate-related disclosure indicators were mapped based on the results of two Delphi rounds. Overall, 52.5% (21/40) of climate-related disclosure indicators were identified as highly applicable. Among these highly relevant indicators, there were 10% (2/21) of Governance, 24% (5/21) of Strategy, 42% (9/21) of Risk Management and 24% (5/21) of Quality Indicators. Metrics and Goals. Furthermore, around 20% (8/40) of climate-related disclosure indicators received 100% approval from experts. Research implications: Os resultados deste estudo fornecem contribuições práticas para os órgãos de normatização nacionais, visando a criação de normas de divulgação relacionadas ao clima mais eficientes e menos onerosas para as empresas brasileiras. Esta melhoria enfatiza a relevância dos resultados do estudo para a elaboração de normas de divulgação relacionadas ao clima no contexto brasileiro. Originality/value: Brazil is currently in the process of preparing the bases for adopting sustainability standards issued by the International Sustainability Standards Board (ISSB). Before this new standard is implemented effectively, the Federal Accounting Council (CFC) and the Brazilian Sustainability Pronouncements Committee (CBPS) recognized the importance of harmonizing the main disclosure indicators of this standard with Brazilian regulations and business characteristics. In this case, the contribution of several thematic working groups may be necessary, especially with regard to the mechanism that allows entities with varying capabilities and levels of preparation to apply this new standard. This study made an academic contribution by demonstrating the use of the Delphi method as a corroboration tool for defining an accounting standard.
The concept of placing in the Arctic the productive forces on the basis of A. E. Yunitsky infrastructure of the second level and the spatial model of the transport network "Polar lace" for "mobile settlements"

For transition from the mono industry type model of development of Arctic territories and ports to the model of their high-tech development at the example its Ural sector the concept of placing in the Arctic the productive forces on the basis of innovative A. E. Yunitsky infrastructure of the second level and the spatial model of the transport network "Polar lace" for "mobile settlements" have been offered. Ключевые слова: Арктика, Урал, порты, взаимосвязанное развитие, инфраструктура второго уровня А. Э. Юницкого, транспортная сеть "Полярное кружево", инновационные мобильные поселения.
Improving Guideline-Recommended Colorectal Cancer Screening in a Federally Qualified Health Center (FQHC): Implementing a Patient Navigation and Practice Facilitation Intervention to Promote Health Equity

Background: Colorectal cancer (CRC) screening is effective in the prevention and early detection of cancer. Implementing evidence-based screening guidelines remains a challenge, especially in Federally Qualified Health Centers (FQHCs), where current rates (43%) are lower than national goals (80%), and even lower in populations with limited English proficiency (LEP) who experience increased barriers to care related to systemic inequities. Methods: This quality improvement (QI) initiative began in 2016, focused on utilizing patient navigation and practice facilitation to addressing systemic inequities and barriers to care to increase CRC screening rates at an urban FQHC, with two clinical locations (the intervention and control sites) serving a diverse population through culturally tailored education and navigation. Results: Between August 2016 and December 2018, CRC screening rates increased significantly from 31% to 59% at the intervention site (p < 0.001), with the most notable change in patients with LEP. Since 2018 through December 2022, navigation and practice facilitation expanded to all clinics, and the overall CRC screening rates continued to increase from 43% to 50%, demonstrating the effectiveness of patient navigation to address systemic inequities. Conclusions: This multilevel intervention addressed structural inequities and barriers to care by implementing evidence-based guidelines into practice, and combining patient navigation and practice facilitation to successfully increase the CRC screening rates at this FQHC.
Aboriginal values, sacred landscapes, and resource development in the Cariboo Chilcotin region of BC.

The Aboriginal values and epistemologies of Indigenous peoples in the Cariboo and Chilcotin region of British Columbia are nested within one of the province's resource development hinterlands. These geographic locations are the birthplace of various cultures, legends, and stories of Indigenous groups. Resource developments at these locations continue to highlight the collision of values arising from urban-remote interactions. Using a hybrid approach of grounded theory and Indigenous research methodology, this dissertation uses two case studies to capture (1) the struggles and resistance of the Indigenous Tsilhqot'in communities as they defend their land against an incumbent mining company and (2) insights into Aboriginal community planning through documenting the Nazko First Nation's Comprehensive Community Planning process. Major themes addressed in this study are (1) Aboriginal values expressed during a Federal Panel Assessment of a proposed mine development in the Cariboo Chilcotin region (2) the contemporary culture of the Tsilhqot'in people including how some women continue to survive on the land and (3) geothermal energy as a potential primary resource. Outcomes of this research study highlight the critical Aboriginal values within the Cariboo Chilcotin region, and how these values are important considerations in resource development decisions. These outcomes provide new insights into how cultural values are embedded within traditional activities and landscapes. Furthermore, the findings show that despite contemporary challenges, community values continue to influence resource development considerations and choices made by the Aboriginal people. This research concludes with new theory propositions about Native Space and why the location and ecological footprint of resource development within the traditional territories of Aboriginal people are important in meeting the needs of their daily lives. --Leaf ii.
Intangible Assets and R&D to the Value of New IPO Companies with Financial Performance as Moderating Variable

This study uses an explanatory quantitative design to determine the influence of research and development intensity and intangible assets on firm value with financial performance as a moderation variable. This study aims to add to the investor literature by providing a way to assess new companies in 2020 that initially conducted public offerings. Financial performance is used as a moderator to see whether it will strengthen the relationship between variables or weaken it. Companies in 2020 that have just made an initial public offering and disclosed research and development costs, recorded profits in financial statements, and value from intangible assets will be the sample in this study. Secondary data was used in this study from the Indonesia Stock Exchange with a moderation regression data analysis technique. This study indicates that firm value does not affect the intensity of research and development and intangible assets. However, intangible assets have a stronger relationship with firm value with moderating financial performance. Keywords: intangible assets, R&D, firm value, financial performance, initial public offering
Structural styles from the Central Graben in the UK and Norway

A selection of structural styles observed on seismic data from the UK and Norwegian sectors of the Central Graben is presented. The interpretation of these structures is based on a polyphase tectonic model of structural evolution of the North Sea Basin which has been facilitated by the improved quality of pre-Base Cretaceous reflections seen on the increasingly available 3D seismic surveys. The structural evolution of the Central Graben can be represented by a model invoking two main phases of structural development. Much of the basement framework was created during the Caledonian orogeny which gave rise to NW–SE- and NE–SW-trending diffuse shear zones. Subsequent repeated reactivation along these existing basement lineaments occurred from Late Paleozoic to Cenozoic times. During the late Jurassic to early Cretaceous, the maximum principal stress axis was orientated approximately N–S to NNE–SSW and the minimum principal stress axis orientated E–W to ESE–WNW. Because this stress field was at an angle to the existing framework trends, most of the faults were reactivated with an oblique-slip component which resulted in the formation of transpressional and transtensional features of varying orders of magnitude. Fault movements also locally activated halokinesis which further complicated the structural development. Seismic examples illustrate how the introduction of an element of oblique-slip can clarify the interpretation of many of the observed structures in the UK and Norwegian Central Graben. Although often subtle in appearance, oblique-slip movements and corresponding zones of transpression and transtension must be identified before a clear picture of localized structural and sedimentary histories can emerge.
The Therapeutic Mechanisms of Mesenchymal Stem Cells in MS—A Review Focusing on Neuroprotective Properties

In multiple sclerosis (MS), there is a great need for treatment with the ability to suppress compartmentalized inflammation within the central nervous system (CNS) and to promote remyelination and regeneration. Mesenchymal stem cells (MSCs) represent a promising therapeutic option, as they have been shown to migrate to the site of CNS injury and exert neuroprotective properties, including immunomodulation, neurotrophic factor secretion, and endogenous neural stem cell stimulation. This review summarizes the current understanding of the underlying neuroprotective mechanisms and discusses the translation of MSC transplantation and their derivatives from pre-clinical demyelinating models to clinical trials with MS patients.
A Novel Magnetic High-Permeable Thin-Film Electroplated-On-Nail Approach for Electromagnetic Targeting in Intramedullary Interlocking-Nail Surgery

In this article, we report a novel magnetic high-permeable NiFe thin-film electroplated-on-nail approach for electromagnetic targeting in intramedullary interlocking-nail surgery. The electromagnetic targeting system consists of a specific nail (on which a magnetic high-permeable NiFe thin film is electroplated onto specific outer and inner surfaces of the nail), a C-shape electromagnet module (includes a C-shaped silicon steel core, emitting coil, and receiving coil), guiding mechanism, and measurement electronics. An ac input voltage is applied to the emitting coil to produce an ac magnetic flux/field in the air gap between the emitting coil and the receiving coil. Consequently, this induces a corresponding ac voltage in the receiving coil. When the C-shape electromagnet module with the producing constant magnetic field is used to scan the nail, the magnetic flux/field is influenced (concentrated) by the magnetic thin film on the outside and inside surfaces of the nail, and thus, the induced voltage of the receiving coil is changed. Through analyzing the changes in the induced voltage, the location and orientation of the thin film are obtained. Because the distance between the thin film and the screw hole is already known when electroplating thin film onto the specific regions of the nail, the location and orientation of the distal screw hole are also obtained. According to blind tests, our test results show that the maximum targeting error of the location- and orientation-targeting are 1.06 mm and 3.76°, respectively, with a success rate of 96%. Due to these results, our approach not only can achieve a decent targeting accuracy, but also does not necessitate any placement of any bulk components (such as sensors or coils) inside the nail, which is generally required by conventional approaches. The placement of bulk components generally causes a retrieving problem (difficult to retrieve the components from the inside of the nail to the outside of the bone/body) during the surgery and can be solved by our approach in this article.
Prevalence, Risk Factors, and Relationship between Reproductive Performance and the Presence of Antibodies against Coxiellosis in Dairy Farm Milk Tanks in the Northwest of Spain

Simple Summary Q fever is an infectious disease caused by Coxiella burnetii that can affect both humans and animals. Given its consequences and the lack of epidemiological data published about its distribution and risk factors, we aimed to evaluate the prevalence of Coxiella burnetii at dairy farms in the northwest of Spain, identify which risk factors favor its occurrence, and the consequences on reproductive performance at the farm level. Bulk tank milk samples were collected from 262 farms and analyzed to identify antibodies against this bacterium. Additionally, data about potential risk factors and reproductive performance were obtained. A total of 60.1% of the farms tested positive for coxiellosis, and the main risk factors were the herd size, the purchase of livestock, and the geographical area. Additionally, conception rate and first-service conception rates were lower in positive farms, which also tended to have higher incidence of reproductive disorders after calving. Abstract Q fever is a zoonotic disease that has been associated with reproductive problems in animals. As there is little epidemiological data regarding the distribution and risk factors of this disorder in cattle, the objective of this study was to evaluate the prevalence of Coxiella burnetii among dairy herds in the northwest of Spain, and to determine the on-farm risk factors associated with the disease and its effects on reproductive performance. Bulk tank milk (BTM) samples were collected from 262 commercial dairy herds from A Coruña, Lugo, and Pontevedra provinces. Data about location, mean age, and herd management features were obtained. A commercial indirect ELISA kit was used to determine the presence of antibodies against C. burnetii in BTM samples. The relationship between seropositivity to C. burnetii and the risk factors was checked using a Pearson’s χ2 test and a classification tree analysis. In addition, a one-way ANOVA test and the Mann–Whitney U test were used to check the impact of seropositivity to C. burnetii on reproductive performance. A total of 60.1% of the farms tested positive for coxiellosis, the herd size, the external purchase of livestock, and the geographical area were identified as the main risk factors. Conception rate and first-service conception rate were significantly lower (p < 0.05) in positive farms (37.1 and 32.9%) compared to negative farms (39.8 and 36.1%). Similarly, positive farms had significant higher incidence of endometritis (13.7% vs. 11.2%, p < 0.05). Consequently, a high seropositivity and slightly negative effects of coxiellosis on reproductive performance were observed, which intensifies the need for further research, including the identification an active infection in positive herds and the characterization of the genotype.
The Influence Of Service Quality, Customer Relationship Management (CRM) And Brand Image On Customer Loyalty With Customer Satisfaction As An Intervening Variable

The aim of this research is to determine and analyze the influence of Service Quality, Customer Relationship Management (CRM) and Brand Image on Customer Loyalty with Customer Satisfaction as an intervening variable. This research uses purposive sampling with a sample of 100 respondents. This research testing uses quantitative methods. The validity test results of all question items are valid because the value of rcount > rtable. The reliability test results of all question items are reliable because the Cronbach Alpha value is> 0.60. The results of the classical assumption test all variables meet the classical assumption criteria. The results of multiple linear regression analysis in this research obtained b1 = 0.133 which shows the positive influence of the Service Quality variable (X1) on customer loyalty (Y). Meanwhile b2 = 0.182 shows the positive influence of CRM variables (X2) on Customer Loyalty (Y). Lastly, b3 = 0.252 shows the positive influence of the Brand Image variable (X3) on Customer Loyalty (Y). To test the hypothesis, there is a partially significant influence between Service Quality (X1) on customer loyalty (Y) with a value of tcount > ttable (3.978 > 1.983). CRM (X2) has a partially significant effect on Customer loyalty (Y) with a value of tcount > ttable (2.164 > 1.983). Brand Image (X3) has a partially significant effect on Customer Loyalty (Y) with a value of tcount > ttable (2.335 > 1.986). Customer Satisfaction (Z) mediates the influence of Service Quality (X1) on Customer Loyalty (Y) with a value of tcount > ttable (14.734 > 1.983). Customer Satisfaction (Z) mediates the influence between CRM (X2) on Customer loyalty (Y) with a value of tcount > ttable (10.335>1.983). Customer Satisfaction (Z) mediates the influence of Brand Image (X3) on Customer Loyalty (Y) with a value of tcount > ttable (10.258 > 1.983). Customer Satisfaction (Z) has a partially significant effect on Customer Loyalty (Y) with a value of tcount > ttable (3.513 > 1.983).
Perspectives on Antarctic conservation: an analysis of New Zealand Antarctic stakeholder views

Perspectives on Antarctic conservation: An analysis of New Zealand Antarctic stakeholder views by Gabriela Paz Gómez Fell The Antarctic, open to all and under no state ownership, is one of the world’s global commons. This area is facing challenges that extend beyond its boundaries. Challenges stemming from global warming, economic utilisation of natural resources, increased human visitation and growing sciencerelated activities in the area that are placing pressure on Antarctica’s unique ecosystems and biodiversity. In an effort to understand stakeholder perspectives from one of the states involved its governance, this study gathered the views of 124 New Zealand Antarctic stakeholders from four key stakeholder groups (government, science, commercial industry and conservationists) on Antarctic conservation. The study used a mixed methods approach, in the form of an online survey and interviews, to gather their views and utilised two opposing common-pool resource (CPR) management frameworks to analyse the data gathered. The study identified stakeholders in Antarctic conservation, challenges and issues facing Antarctic conservation as well as potential future scenarios for Antarctic conservation. Antarctic stakeholders that were identified included governments, members of the science community, those affiliated with specific commercial industries, and conservationists. In addition, the public and Antarctica’s wildlife were also seen as key stakeholders in Antarctic conservation. Issues raised by survey respondents and interviewees included direct and indirect human impacts on the Antarctic environment, particularly the present and future effects of climate change; as well as the potential for resource exploitation beyond harvesting of marine living resources. Although concerns over growing human presence in Antarctica through science, tourism and fishing were expressed, their impacts were deemed minor in contrast to effects from indirect human impacts. Uncertainty over the precise impacts of climate change on Antarctica created speculation towards the future conservation of the area.
Development and Validation of the Attitudes towards Social Robots Scale

The idea of artificially created social robots has a long tradition. Today, attitudes towards robots play a central role in the field of healthcare. Our research aimed to develop a scale to measure attitudes towards robots. The survey consisted of nine questions on attitudes towards robots, sociodemographic questions, the SWOP-K9, measuring self-efficacy, optimism, and pessimism, and the BFI-10, measuring personality dimensions. Structural relations between the items were detected using principal components analysis (PCA) with Varimax rotation. Correlations and Analysis of Variance were used for external validation. In total, 214 participants (56.1% female, mean age: 30.8 ± 14.4 years) completed the survey. The PCA found two main components, “Robot as a helper and assistant” (RoHeA) and “Robot as an equal partner” (RoEqP), with four items each explaining 53.2% and 17.5% of the variance with a Cronbach’s α of 0.915 and 0.768. In the personality traits, “Conscientiousness” correlated weakly with both subscales and “Extraversion” correlated with RoHeA, while none the subscales of the SWOP-K9 significantly correlated with RoEqP or RoHeA. Male participants scored significantly higher than female participants. Our survey yielded a stable and convergent two-factor instrument that exhibited convincing validity and complements other findings in the field. The ASRS can easily be used to describe attitudes towards social robots in human society. Further research, however, should be carried out to investigate the discriminant and convergent validity of the ASRS.