Miracle-dz/UniFAR-FTUs huggingface dataset:
Polyethylene Oxide and their Antibacterial Effects Against some Pathogenic Bacteria

Poly ethylene oxide is an uncrosslinked, non-ionic linear hydrophilic polymer with a variety of molecular weights. PEO is used to make it, and it offers a number of beneficial qualities for medication delivery and antibacterial uses. The antibacterial activity of polyethylene oxide (PEO) at various concentrations as (80, 40, 20, 10 g/ml) against bacteria in Gram-positive Staphylococcus aureus , Streptococcus pyogenes and Lactobacillus sp. and Gram-neg-ative Enterobacter bugandensis , E. coli , Pseudomonas aeruginosa and Klebsiella pneumonia was investigated in this study. The disk diffusion experiment was used to assess the antimicrobial activity of PEO, as well as each isolate’s minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC). PEO is shown to have strong broad-spectrum antibacterial action against the bacteria studied, that inhibition zone increase their width inversely proportional to PEO concentration, and has even outpaced the efficacy of certain medicines. PEO had MICs ranging from 10 to 20 g/ml, as well as MBCs of 20 to 80 g/ml. In additional studies, PEO was discovered to be strongly associated with the cell of bacteria, which contributed to its inhibitory impact on bacterial invasion and growth. PEO at an appropriate dose effectively decreased bacterial growth. PEO is highly recommended as a cost-effective antibacterial treatment, Specifically, ectopic infection treatment without the risk of bacterial strains becoming antibiotic-resistant.
Effects of different levels of rutin on growth performance, immunity, intestinal barrier and antioxidant capacity of broilers

Abstract This study investigated the effects of different doses of rutin on the growth performance, immunity, intestinal barrier, and antioxidant capacity of broilers. A total of two hundred and fifty-six 1-day-old male broilers were divided into 4 groups and fed basal diets supplemented with 0 (control group), 250, 500 and 1,000 mg rutin/kg, respectively, for 42 days. In the starter period (days 1–21) and whole trial period (days 1–42), broilers fed diets containing 500 mg rutin/kg had significantly (p < 0.05) higher average daily feed intake, body weight and average daily gain and better feed conversion ratio. Dietary 500 mg rutin/kg increased the villus height, villus height to crypt depth ratio and villus area, while reducing the B cell lymphoma 2 associated X mRNA expression (p < 0.05). Dietary 500 mg rutin/kg increased the level of IgA in serum and decreased serum tumour necrosis factor-α (TNF-α) content, and the nuclear factor kappa-B, interleukin-2 and TNF-α mRNA expression in jejunal mucosa (p < 0.05). Simultaneously, 500 and 1,000 mg rutin/kg significantly decreased serum diamine oxidase activity, D-lactic acid and lipopolysaccharide concentration, increased activities of total superoxide dismutase and total antioxidant capacity in jejunal mucosa (p < 0.05), and upregulated mRNA expressions of genes related to intestinal barrier and antioxidant capacity in jejunal mucosa (p < 0.05). These findings indicate that dietary rutin, especially at 500 mg/kg, improves broilers’ growth performance, intestinal barrier function, immunity, and antioxidant capability, which may be related to the nuclear factor erythroid-2-related factor 2 (Nrf2) pathway. Highlights Dietary rutin improved growth performance, jejunal morphology, and intestinal barrier function. Dietary rutin enhanced the immunity via inhibiting NF-κB, and improved antioxidant capacity via activating Nrf2/HO-1 pathway in broilers. The optimal dose of rutin was 500 mg/kg in broiler diet.
Construction of Femininity and Consumer Culture in American Women's Magazines: A Qualitative Study about Good Housekeeping

Good housekeeping is one of the mainstream American women's magazines. Targeting primarily the middle-class married women, it gives guidance and suggestions on beautifying appearance, latest fashions,housekeeping, cooking, and child-rearing. Using 24 issues of Good Housekeeping published in 2016-2017, this study explores what kind of femininity is constructed in this magazine. The study uses thematic analysis and interpretive textual analysis as the key methodologies. Furthermore, it explores the overlapping relationships between the magazine, femininity, and consumer culture. The article finds that femininity constructed in those two years of Good Housekeeping tends to be conservative, which is idealized and perfected in the magazine.The magazine has maintained its long-established and conservative style. It is established on a commercialized base and advocates that ideal femininity is to be gained through "purchasing. " The conservative femininity constructed by the magazine is under the manipulation of modern patriarchy and consumerism.
Unidentified Components in Reduced Rank Regression Estimation of ECM's

Reduced rank regression procedures in error correction models (ECM's) permit consistent estimation of the cointegration space but do not provide consistent estimates of individual structural relations when the dimension of the cointegration space is greater than one. Indeed, individual structural cointegrating equations are unidentified without additional a priori restrictions, just as in the conventional simultaneous equations framework. The effect of this lack of identification is explored by considering the distributions and limit distributions of reduced rank regression estimates of unidentified components of the cointegrating matrix in a typical VAR formulation of the ECM. Some recommendations are made for empirical practice.
Genetic Variation among Pharmacogenes in the Sardinian Population

Pharmacogenetics (PGx) aims to identify the genetic factors that determine inter-individual differences in response to drug treatment maximizing efficacy while decreasing the risk of adverse events. Estimating the prevalence of PGx variants involved in drug response, is a critical preparatory step for large-scale implementation of a personalized medicine program in a target population. Here, we profiled pharmacogenetic variation in fourteen clinically relevant genes in a representative sample set of 1577 unrelated sequenced Sardinians, an ancient island population that accounts for genetic variation in Europe as a whole, and, at the same time is enriched in genetic variants that are very rare elsewhere. To this end, we used PGxPOP, a PGx allele caller based on the guidelines created by the Clinical Pharmacogenetics Implementation Consortium (CPIC), to identify the main phenotypes associated with the PGx alleles most represented in Sardinians. We estimated that 99.43% of Sardinian individuals might potentially respond atypically to at least one drug, that on average each individual is expected to have an abnormal response to about 17 drugs, and that for 27 drugs the fraction of the population at risk of atypical responses to therapy is more than 40%. Finally, we identified 174 pharmacogenetic variants for which the minor allele frequency was at least 10% higher among Sardinians as compared to other European populations, a fact that may contribute to substantial interpopulation variability in drug response phenotypes. This study provides baseline information for further large-scale pharmacogenomic investigations in the Sardinian population and underlines the importance of PGx characterization of diverse European populations, such as Sardinians.
PyPLIF HIPPOS and Receptor Ensemble Docking Increase the Prediction Accuracy of the Structure-Based Virtual Screening Protocol Targeting Acetylcholinesterase

In this article, the upgrading process of the structure-based virtual screening (SBVS) protocol targeting acetylcholinesterase (AChE) previously published in 2017 is presented. The upgraded version of PyPLIF called PyPLIF HIPPOS and the receptor ensemble docking (RED) method using AutoDock Vina were employed to calculate the ensemble protein–ligand interaction fingerprints (ensPLIF) in a retrospective SBVS campaign targeting AChE. A machine learning technique called recursive partitioning and regression trees (RPART) was then used to optimize the prediction accuracy of the protocol by using the ensPLIF values as the descriptors. The best protocol resulting from this research outperformed the previously published SBVS protocol targeting AChE.
Credit Information Sharing and Firm Innovation: An Empirical Evidence

This paper investigates the effect of credit information sharing (CIS) on borrower’s innovation activities. On the foundation of unique dataset from developed and developing countries, we find that public credit registries (PCRs) have significant positive relationship with firms’ innovation. These findings contract the facilitative role of CIS in lowering firm’s cost of capital and boost efficiency. Out findings are robust to different specifications and alternative measures. After the establishment of PCRs, firms may benefit more if these firms have more power in enforcing the contracts and have dispersed banking environment. These findings are aligned with the perspective that improvements in creditors’ information sets leads to innovative portfolios and better financing opportunities.
A Unique Approach for Functionalization of Cotton Substrate with Sustainable Bio-based Vanillin for Multifunctional Effects

ABSTRACT Exploration of novel bio-based materials for value addition of textile substrates is a desirable research trend. In this context, vanillin (4-hydroxy-3-methoxybenzaldehyde), a bio-based material (obtained from vanilla pod) having multifunctional properties, can be a well-suited candidate. In the present article, both the vanillin alone and vanillin–copper (vanillin-Cu) complexes have been incorporated into cotton textiles separately using a high temperature-high pressure (HT-HP) dyeing machine and the quantity of copper has successfully been optimized to demonstrate enhanced properties. The vanillin-treated fabric has shown very good all-round properties like ultraviolet protection factor (UPF), color value (K/S value), and antibacterial activity (AM) in the presence of copper salt. However, only vanillin itself has rendered as such no UPF value but demonstrated 70% antimicrobial activity against E. coli (Gram-negative) bacteria and during washing operation small molecules of vanillin get leached out of fabric (as represented by significant loss in properties). This is the first time that the functional properties of vanillin and vanillin-Cu complex have directly been explored on cotton textile wherein significantly enhanced properties have been achieved on vanillin-Cu complex-treated fabric (i.e. 99% AM, a good UPF factor of 78, K/S value of 11.55, and even 25% antioxidant activity).
Efficacy of Alendronate in Preventing Periprosthetic Bone Loss after Implantation of a Primary Hip Endoprosthesis

Total hip arthroplasty (THA) is now the gold standard for the surgical treatment of coxarthrosis. The appearance of bone loss after implantation of the hip endoprosthesis over time reduces the primary stability of the implant and leads to progressive looseningof the implant, or periprosthetic fracture, which are considered to be the most common causes of hip revision. The aim of this study is to evaluate the value of alendronate application in reducing periprosthetic osteolysis reduction after implantation of total cementless hip endoprosthesis. The study analyzed 50 patients operated on with implantation of a cementless total hip arthroplasty (THA). The first group of 25 patients recieved oral alendronate, calcium and vitamin D3 postoperatively. The second group of 25 patients were examined and followed postoperatively without any therapy. Patients were examined by RTG and DXA methods at 6, 12 and 18 months. The study showed a difference in the values of bone mineral density (BMD) and bone mineral content (BMC) in the interval of 6,12 and 18 months, using the DXA method. Alendronate therapy after total hip implantation reduces periprosthetic bone loss, maintains bone mineralization and strengthens the implant
Electroacupuncture Stimulation Suppresses Postoperative Inflammatory Response and Hippocampal Neuronal Injury

Postoperative cognitive dysfunction (POCD) is consequence of anesthesia and surgery that primarily affects older people. The prevention and treatment of POCD has drawn an increasing attention in recent decades. Here, we established the animal model mimicked POCD after femoral fracture surgery, and analyze the effect of acupuncture stimulation on postoperative cognitive function after femoral fracture surgery. Compared with the mock group, the cognitive function performance was significantly decreased both in the anaesthesia group and the surgery group, between which the symptoms were more severe in the surgery group. The peripheral inflammation response and the neuron impairment and inflammation response in the hippocampus were observed in the surgery group, but only peripheral inflammation response was detected in the anaesthesia group. These findings indicated the POCD was the synergistic outcome of anaesthesia and surgical stimulation but with different pathogenic mechanism. The surgery with mental tri-needles (surgery+MTN) group outperformed the surgery group in terms of cognitive function performance. The peripheral inflammation response and the neuron impairment and inflammation response in the hippocampus was significantly reduced by the electroacupuncture stimulation. Our findings indicated the protection of electroacupuncture form POCD after femoral fracture surgery is related to the inhibition of inflammation response and neuron impairment.
Large force actuator using an electro-adhesive gel super multi-disk

Actuators with clutch mechanisms have advantages in safety, backdriveability, and controllability for human-coexistence robots. This paper presents a large force actuator using electro-adhesive gels, which are functional materials controlled by the magnitude of an electric field. The developed actuator can generate and continuously control a force over 560 N and resist with a small force when de-energized. The number of electro-adhesive gel disks is drastically increased to increase the generative force. This paper reports the structural plan for the new actuator and experiments to investigate its basic characteristics. Based on the experimental results, an actuator model is identified for the future design of its control system. This paper contributes to the development of a clutch-type linear actuator with a large generative force, maintaining safety and a high force-to-weight ratio. It also addresses the problem of high-voltage power supply costs for electro-rheological and electro-adhesive materials. GRAPHICAL ABSTRACT
Limnological characteristics of Lake of the Ozarks (Missouri, USA): long-term assessment following formation of a reservoir series

Abstract Jones JR, Obrecht DV, Thorpe AP. 2022. Limnological characteristics of Lake of the Ozarks (Missouri, USA): long-term assessment following formation of a reservoir series. Lake Reserv Manage. 38:288–303. Impoundment of Truman Lake in 1980 on the Osage River, above Lake of the Ozarks (LOTO), created a reservoir series. This analysis details the changes and processes over the ensuing 35 yr (1980–2014) in this large impoundment dominated by a longitudinal gradient along the mainstem. Temporal variation was determined by hydrology; seasonal mean total phosphorus (TP) ranged between 12 and 58 µg/L at the near-dam location, and hydrologic flushing during summer explained 82% of this variation. After dam closure, mineral suspended solids, attributed to channel scouring of erodible materials in the tailwater reach, declined over time, with a 50% reduction near the dam. Concurrently, organic suspended solids increased by 1 to 4%/yr in mid-reach locations, which indicates greater autotrophic production. Compared with other Missouri reservoirs, algal chlorophyll (Chl) averaged 1.6 times the value predicted from TP. Ratios of Chl:TP have increased over past decades concurrent with an increase in organic suspended solids and expansion of the ultraplankton (<11 µm) fraction of total Chl. Warm and dry conditions are associated with an increase in Chl in the ultra fraction, suggesting climate influence. A comparison with data collected prior to the closure of Truman Dam (1976–1979) provides incontrovertible evidence that light transmission has improved, and both Chl and Chl:TP have increased in LOTO. Formation of a reservoir series resulted in immediate and long-term changes in this major impoundment.
Optimized Method for the Identification of Candidate Genes and Molecular Maker Development Related to Drought Tolerance in Oil Palm (Elaeis guineensis Jacq.)

Drought is a major constraint in oil palm (Elaeis guineensis Jacq.) production. As oil palm breeding takes a long time, molecular markers of genes related to drought tolerance characteristics were developed for effective selection. Two methods of gene identification associated with drought, differential display reverse transcription polymerase chain reaction (DDRT-PCR) and pyrosequencing platform, were conducted before developing the EST-SSR marker. By DDRT-PCR, fourteen out of twenty-four primer combinations yielded the polymorphism in leaf as 77.66% and root as 96.09%, respectively. BLASTN and BLASTX revealed nucleotides from 8 out of 236 different banding similarities to genes associated with drought stress. Five out of eight genes gave a similarity with our pyrosequencing sequencing database. Furthermore, pyrosequencing analysis of two oil palm libraries, drought-tolerant, and drought sensitive, found 117 proteins associated with drought tolerance. Thirteen out of sixty EST-SSR primers could be distinguished in 119 oil palm parents in our breeding program. All of our found genes revealed an ability to develop as a molecular marker for drought tolerance. However, the function of the validated genes on drought response in oil palm must be evaluated.
Increased Body Mass Index and Risk of Left Atrial Thrombus in Nonvalvular Atrial Fibrillation Patients—Data from the Left Atrial Thrombus on Transesophageal Echocardiography (LATTEE) Registry

An increased body mass index (BMI) is associated with a higher incidence of atrial fibrillation (AF) and a higher risk of thromboembolic complications in AF patients. The aim of this study was to investigate the effect of BMI on the risk of left atrial thrombi (LATs) in patients with nonvalvular AF/atrial flutter (AFl) (NV AF/AFl). Patients diagnosed with NVAF/AFl (between November 2018 and May 2020) were selected from the multicenter, prospective, observational Left Atrial Thrombus on Transesophageal Echocardiography (LATTEE) registry that included AF/AFl patients referred for cardioversion or ablation followed by transesophageal echocardiography. A total of 2816 AF/AFl patients (63.6% males; mean age 65.8 years; mean BMI 29.8 kg/m2) were included in the study. Two hundred and twenty-two of them (7.9%) had LATs. Compared with normal-weight patients, those with BMIs ≥ 25 kg/m2 more frequently presented clinical factors potentially provoking LATs, such as non-paroxysmal AF/AFl (p = 0.04), hypertension (p < 0.001), and diabetes (p < 0.001); had higher CHA2DS2 scores (p < 0.001); and had larger LA dimensions (LA diameter and LA area) (p < 0.001 for both parameters). On the other hand, they showed some features negatively related to thromboembolic risk; for example, they were younger (p < 0.001) and were more often male (p = 0.002). In addition, patients with abnormal BMIs were more likely to be smokers (p = 0.006) and to be treated with oral anticoagulants (p = 0.005). Despite these differences in the prevalence of thromboembolic risk factors, the incidence of LATs was not increased in patients with abnormal body weight (overweight and obese compared to normal-weight patients) in this large real-life cohort of AF/AFl patients. This is probably due to the balanced composition regarding the prevalence of positive and negative thromboembolic risk factors.
Microbiological and Clinical Findings of SARS-CoV-2 Infection after 2 Years of Pandemic: From Lung to Gut Microbiota

Early recognition and prompt management are crucial for improving survival in COVID-19 patients, and after 2 years of the pandemic, many efforts have been made to obtain an early diagnosis. A key factor is the use of fast microbiological techniques, considering also that COVID-19 patients may show no peculiar signs and symptoms that may differentiate COVID-19 from other infective or non-infective diseases. These techniques were developed to promptly identify SARS-CoV-2 infection and to prevent viral spread and transmission. However, recent data about clinical, radiological and laboratory features of COVID-19 at time of hospitalization could help physicians in early suspicion of SARS-CoV-2 infection and distinguishing it from other etiologies. The knowledge of clinical features and microbiological techniques will be crucial in the next years when the endemic circulation of SARS-CoV-2 will be probably associated with clusters of infection. In this review we provide a state of the art about new advances in microbiological and clinical findings of SARS-CoV-2 infection in hospitalized patients with a focus on pulmonary and extrapulmonary characteristics, including the role of gut microbiota.
Comparison of Strong Gravitational Lens Model Software III. Direct and indirect semi-independent lens model comparisons of COSMOS J095930+023427, SDSS J1320+1644, SDSSJ1430+4105 and J1000+0021

Analysis of strong gravitational lensing data is important in this era of precision cosmology. The objective of the present study is to directly compare the analysis of strong gravitational lens systems using different lens model software and similarly parameterized models to understand the differences and limitations of the resulting models. The software lens model translation tool, HydraLens, was used to generate multiple models for four strong lens systems including COSMOS J095930+023427, SDSS J1320+1644, SDSSJ1430+4105 and J1000+0021. All four lens systems were modeled with PixeLens, Lenstool, glafic, and Lensmodel. The input data and parameterization of each lens model was similar for the four model programs used to highlight differences in the output results. The calculation of the Einstein radius and enclosed mass for each lens model was comparable. The results were more dissimilar if the masses of more than one lens potential were free-parameters. The image tracing algorithms of the software are different, resulting in different output image positions and differences in time delay and magnification calculations, as well as ellipticity and position angle of the resulting lens model. In a comparison of different software versions using identical model input files, results differed significantly when using two versions of the same software. These results further support the need for future lensing studies to include multiple lens models, use of open software, availability of lens model files use in studies, and computer challenges to develop new approaches. Future studies need a standard nomenclature and specification of the software used to allow improved interpretation, reproducibility and transparency of results.