Miracle-dz/UniFAR-FTUs huggingface dataset:
Energy fluxes at the air-snow interface

Modelling the energy exchange between the snowpack and the atmosphere is critical for many hydrological applications. Of the terms present in the snow energy balance, the turbulent fluxes of sensible and latent heat are the most challenging to estimate, particularly within mountain environments where the hydrological importance is great. Many of the flux estimation techniques, such as the bulk transfer method, are poorly adapted for use in complex terrain. In order to characterize the turbulence and to assess the suitability of flux estimation techniques, eddy covariance flux measurements and supporting meteorological data were collected from two mountain valley forest openings in Kananaskis Country, AB. These sites were generally calm, however wind gusts were frequently observed which markedly affected the turbulence characteristics and increased the rates of momentum and heat transfer. In order to successfully apply the bulk transfer technique at these sites, it was necessary to use environment-specific transfer coefficients to account for the effect of the surrounding complex terrain. These observations were compared with data collected on a treeless alpine ridge near Whitehorse, YT, where it was found that many of the turbulence characteristics were similar to flat sites. However, the boundary layer formed over the alpine ridge was very thin and the site was poorly suited for estimating surface fluxes. The mountain results were further contrasted with data collected over a homogeneous and flat prairie site located near Saskatoon, SK. This site included measurement of all of the snow energy terms, permitting an estimate of the energy balance closure obtainable over snow surfaces. The observed energy balance residual was very large, indicating that the eddy covariance technique was unable to capture all of the turbulent energy. It was concluded that an unmeasured transfer of sensible heat was occurring which was strongly correlated with the long-wave radiation balance. Mechanisms for this relationship were hypothesized. Two snow energy balance models were used to investigate the energy imbalance, where it was observed that the flux terms could be suitably simulated if effective parameters were used to augment the sensible heat transfer rate. The results from this thesis contribute to the understanding of heat transfer processes over snow surfaces during mid-winter conditions and improve the ability to model turbulent heat and mass fluxes from snow surfaces in complex environments.
Application of Carbon Nanotubes to Counter Electrodes of Dye-sensitized Solar Cells

In order to search for an efficient counter electrode in a dye-sensitized solar cells, three kinds of nano-carbon materials were examined. When single wall carbon nanotubes (SWCNTs) were used as a carbon electrode, the conversion efficiency of the cells is 4.5%. This value is comparable to Gratzel-type dye-sensitized solar cell (counter electrode: platiun-suputtered fluorine-doped tin oxide) under the same experimental condition.
Alternative Materials for Dense Medium Separations

In response to concerns regarding cost and future supply of magnetite, a study has been performed to evaluate the potential of alternative materials that can be used to generate a dense medium for coal-cleaning applications. Alternative materials included waste steel slag, fine sand, and high-density material existing in run-of-mine feed. Under certain conditions, each of the materials tested provided separation efficiencies that meet industrial standards including probable error values of around 0.03. Dense medium derived from the non-magnetite sources achieved organic efficiency values exceeding the 95% level over a medium density range from 1.3 RD to 1.6 RD with lower than normal density offsets. Lower cost, coarse magnetite provided excellent separation efficiencies when medium density values above 1.6 RD are sufficient to meet product grade requirements.
Metabolic Evaluation of the Dietary Guidelines’ Ounce Equivalents of Protein Food Sources in Young Adults: A Randomized Controlled Trial

ABSTRACT Background The Dietary Guidelines for Americans (DGAs) published an “ounce equivalents” recommendation to help consumers meet protein requirements with a variety of protein food sources. However, the metabolic equivalency of these varied protein food sources has not been established. Objective We have investigated the hypothesis that the anabolic responses to consumption of ounce equivalents of protein food sources would be directly related to the essential amino acid (EAA) content of the protein food source. Methods Following 3 d of dietary control, a total of 56 healthy young adults underwent an 8.5-h metabolic study using stable isotope tracer methodology. The changes from baseline following consumption of 1 of 7 different protein food sources were compared with the baseline value for that individual (n = 8 per group). Results Consumption of ounce equivalents of animal-based protein food sources (beef sirloin, pork loin, eggs) resulted in a greater gain in whole-body net protein balance above baseline than the ounce equivalents of plant-based protein food sources (tofu, kidney beans, peanut butter, mixed nuts; P < 0.01). The improvement in whole-body net protein balance was due to an increase in protein synthesis (P < 0.05) with all the animal protein sources, whereas the egg and pork groups also suppressed protein breakdown compared with the plant protein sources (P < 0.01). The magnitude of the whole-body net balance (anabolic) response was correlated with the EAA content of the protein food source (P < 0.001). Conclusion The “ounce equivalents” of protein food sources as expressed in the DGAs are not metabolically equivalent in young healthy individuals. The magnitude of anabolic response to dietary proteins should be considered as the DGAs develop approaches to establish healthy eating patterns.
Loading of doxorubicin on poly(methyl methacrylate-co-methacrylic acid) nanoparticles and release study

Abstract Nanoparticles (NP) of 12.7 nm in diameter of the poly(methyl methacrylate (MMA)-co-methacrylic acid (MAA)) copolymer were prepared. 13C-NMR results showed a MMA:MAA molar ratio of 0.64:0.36 in the copolymer, which is similar to the poly(MMA-co-MAA) commercially known as the FDA approved Eudragit S100 (0.67:0.33). The NP prepared in this study were loaded at pH 5 with varying amounts (from 0.54 to 6.91%) of doxorubicin (DOX), an antineoplastic drug. 1H-NMR results indicated the electrostatic interactions between the ionized carboxylic groups of the MAA units in the copolymer and the proton of the glycosidic amine in DOX. Measurements by QLS and TEM indicated that the loading destabilizes the NP, and that for increase stability, they aggregate in a reversible way, forming aggregates with a diameter up to 99.5 nm at a DOX load of 6.91%. The analysis of drug release data at pH 7.4 showed that loaded NP with at least 4.38% DOX release the drug very slowly and follows the Higuchi model; the former suggests that they could remain for long periods in the bloodstream to reach and destroy cancer cells.
A Randomized Controlled Pilot Exercise and Protein Effectiveness Supplementation Study (EXPRESS) on Reducing Frailty Risk in Community-Dwelling Older People

Abstract This pilot study aimed to examine the feasibility and effectiveness of a 6-months multi-component exercise program combined with twice daily consumption of either rice (RicePro) or whey-based (WheyPro) protein supplements (2 × 20 g of protein) on gait speed, grip strength and physical performance in community-dwelling pre-frail and frail older adults. Secondary outcomes included: frailty score, muscle mass, quality of life, nutritional intake, cognitive performance, depression and physical activity levels. A total of 70 participants (mean age 73.34 ± 6.85 years) were randomly allocated to either RicePro (n = 36) or WheyPro (n = 34). No adverse events were reported in regards to the exercise, however, several gastrointestinal symptoms were noted with the whey protein causing two-fold more symptoms compared to the rice protein. No differences were found between the groups (p > 0.05), except the total consumed energy (kJ) (p = 0.014) and fat (g) (p = 0.012) which was significantly lower in WheyPro. The results indicate that the quality of protein may not be as important as long as a sufficient amount is consumed.
The gut microbiota during the progression of atherosclerosis in the perimenopausal period shows specific compositional changes and significant correlations with circulating lipid metabolites

ABSTRACT Atherosclerosis (AS) is exacerbated in the perimenopausal period, which significantly increases the incidence rate of cardiovascular disease. The disruption of the gut microbiota has been associated with AS or menopause, but the specific changes of AS-associated gut microbiota in the perimenopausal period remain largely unknown. As lipid abnormalities are mainly responsible for AS, the relationship between lipid metabolism abnormalities and gut microbiota disruptions during menopause is rarely reported hitherto. In the present study, ApoE−/- mice fed with a high-fat diet (HFD) were subjected to ovariectomy and supplemented with estrogen. The ovariectomized HFD-fed ApoE−/- mice underwent significant AS damage, hepatic lipid damage, hyperlipidemia, and changes of lipid metabolism- and transport-related enzymes. There was significantly higher abundance of some lipid metabolites in the plasma of ovariectomized HFD-fed ApoE−/- mice than in non-ovariectomized ones, including cholesterol esters, triglycerides, phospholipids, and other types of lipids (free fatty acids, acylcarnitine, sphingomyelins, and ceramides). The administration of estrogen significantly reduced the contents of most lipid metabolites. The diversity and composition of gut microbiota evidently changed in ovariectomized HFD-fed ApoE−/- mice, compared to HFD-fed ApoE−/- mice without ovariectomy. In contrast, with estrogen supplementation, the diversity and composition of gut microbiota were restored to approach that of non-ovariectomized HFD-fed ApoE−/- mice, and the relative abundances of some bacteria were even like those of C57BL/6 mice fed with a normal diet. On the other hand, the transplantation of feces from C57BL/6 mice fed with normal diet to ovariectomized HFD-fed ApoE−/- mice was sufficient to correct the hyperlipidemia and AS damage, and to reverse the characteristics changing of lipid metabolomics in ovariectomized HFD-fed ApoE−/- mice. These phenomena were also been observed after transplantation of feces from estrogen-treated ovariectomized HFD-fed ApoE−/- mice to ovariectomized HFD-fed ApoE−/- mice. Moreover, the gut microbiota and lipid metabolites were significantly correlated, demonstrating that the changes of serum lipids may be associated with the gut microbiota disruptions in the perimenopausal period. In conclusion, the gut microbiota during the progression of AS in the perimenopausal period showed specific compositional changes and significant correlations with circulating lipid metabolites. Estrogen supplementation may exert beneficial effects on gut bacteria and lipid metabolism.
Attribution Theory, Bystander Effect and Willingness to Intervene in Intimate Partner Violence

Intimate partner violence (IPV) is a crime that is afflicted by a current or previous romantic relationship partner. One in four women has experienced IPV at least once in their lifetime, with physical and psychological consequences. IPV cases tend to go largely unnoticed and under-reported, with low rates of intervention by bystanders. This cross-sectional correlational study investigated whether a combination of attribution theory and the bystander effect could predict the willingness of strangers to intervene in IPV. There were two models tested. The first model examined attitudes towards the victim, while the second one examined attitudes towards the perpetrator. The relationship between perceived responsibility and willingness to intervene was hypothesized to be mediated by sympathy and anger, with the number of bystanders as a moderator to mediating pathways (sympathy towards victim and anger towards perpetrator). A convenience sample of 278 Australian residents aged 18-years and older was presented in a vignette depicting an IPV incident occurring in public. Participants completed measures about the vignette in an online questionnaire. Model testing was conducted using MPlus; confirmatory factor analysis indicated a good fit of the measurement models. After controlling potential covariates, moderated mediation models of victim and perpetrator were analyzed. Attribution theory was a significant predictor in willingness to intervene (f² = .23, p < .001), but the bystander effect was not. Both attitudes towards victim and perpetrator accounted for unique variance in willingness to intervene in IPV, highlighting the importance of examining both. Findings indicate that psychoeducation campaigns aimed at reducing victim-blaming and promoting intervening behavior could be an effective means of preventing IPV.
Insights into the molecular basis of tick-borne encephalitis from multiplatform metabolomics

Background Tick-borne encephalitis virus (TBEV) is the most prevalent arbovirus, with a tentative estimate of 10,000 to 10,500 infections occurring in Europe and Asia every year. Endemic in Northeast China, tick-borne encephalitis (TBE) is emerging as a major threat to public health, local economies and tourism. The complicated array of host physiological changes has hampered elucidation of the molecular mechanisms underlying the pathogenesis of this disease. Methodology/Principle findings System-level characterization of the serum metabolome and lipidome of adult TBEV patients and a healthy control group was performed using liquid chromatography tandem mass spectrometry. By tracking metabolic and lipid changes during disease progression, crucial physiological changes that coincided with disease stages could be identified. Twenty-eight metabolites were significantly altered in the sera of TBE patients in our metabolomic analysis, and 14 lipids were significantly altered in our lipidomics study. Among these metabolites, alpha-linolenic acid, azelaic acid, D-glutamine, glucose-1-phosphate, L-glutamic acid, and mannose-6-phosphate were altered compared to the control group, and PC(38:7), PC(28:3;1), TAG(52:6), etc. were altered based on lipidomics. Major perturbed metabolic pathways included amino acid metabolism, lipid and oxidative stress metabolism (lipoprotein biosynthesis, arachidonic acid biosynthesis, leukotriene biosynthesis and sphingolipid metabolism), phospholipid metabolism and triglyceride metabolism. These metabolites were significantly perturbed during disease progression, implying their latent utility as prognostic markers. Conclusions/Significance TBEV infection causes distinct temporal changes in the serum metabolome and lipidome, and many metabolites are potentially involved in the acute inflammatory response and immune regulation. Our global analysis revealed anti- and pro-inflammatory processes in the host and changes to the entire metabolic profile. Relationships between metabolites and pathologies were established. This study provides important insight into the pathology of TBE, including its pathology, and lays the foundation for further research into putative markers of TBE disease.
Response diversity in corals: hidden differences in bleaching mortality among cryptic Pocillopora species

Abstract Variation among functionally similar species in their response to environmental stress buffers ecosystems from changing states. Functionally similar species may often be cryptic species representing evolutionarily distinct genetic lineages that are morphologically indistinguishable. However, the extent to which cryptic species differ in their response to stress, and could therefore provide a source of response diversity, remains unclear because they are often not identified or are assumed to be ecologically equivalent. Here, we uncover differences in the bleaching response between sympatric cryptic species of the common Indo‐Pacific coral, Pocillopora. In April 2019, prolonged ocean heating occurred at Moorea, French Polynesia. 72% of pocilloporid colonies bleached after 22 d of severe heating (>8oC‐days) at 10 m depth on the north shore fore reef. Colony mortality ranged from 11% to 42% around the island four months after heating subsided. The majority (86%) of pocilloporids that died from bleaching belonged to a single haplotype, despite twelve haplotypes, representing at least five species, being sampled. Mitochondrial (open reading frame) sequence variation was greater between the haplotypes that experienced mortality versus haplotypes that all survived than it was between nominal species that all survived. Colonies > 30 cm in diameter were identified as the haplotype experiencing the most mortality, and in 1125 colonies that were not genetically identified, bleaching and mortality increased with colony size. Mortality did not increase with colony size within the haplotype suffering the highest mortality, suggesting that size‐dependent bleaching and mortality at the genus level was caused instead by differences among cryptic species. The relative abundance of haplotypes shifted between February and August, driven by declines in the same common haplotype for which mortality was estimated directly, at sites where heat accumulation was greatest, and where larger colony sizes occurred. The identification of morphologically indistinguishable species that differ in their response to thermal stress, but share a similar ecological function in terms of maintaining a coral‐dominated state, has important consequences for uncovering response diversity that drives resilience, especially in systems with low or declining functional diversity.
Evaluation of antioxidant and antimicrobial activity of Vitex agnus castus L.

Antioxidant and antimicrobial activities of methanolic extract of Vitex agnus castus were studied. The antioxidant properties of the extracts were evaluated using different antioxidant tests, including ferric chelating, scavenging activity of hydrogen peroxide and cupric reducing antioxidant capacity. The highest antioxidant activity was observed to be 93.5±0.8% by scavenging activity of hydrogen peroxide. However, total flavonoid and phenolic content of the methanolic extract were determined. Antimicrobial activity tests were carried out using disc diffusion method and broth microdilution method with 7 bacteria and 1 yeast. Results suggested that Vitex agnus castus may be important in variety improvement, nutraceuticals, bio-pharmaceuticals and food additives as possible cost-effective natural antioxidant.
Diversity of human sapovirus genotypes detected in Japanese pediatric patients with acute gastroenteritis, 2014–2017

Sapovirus (SaV) is one of the pathogens related to acute gastroenteritis (AGE) in adults and children worldwide. This study reported the diversity of SaV genotypes in children with AGE in Japan from July 2014 to June 2017. Of a total of 2259 stool samples tested by using reverse transcription‐PCR method and further analyzed by nucleotide sequencing, 114 (5.0%) were positive for SaV and GI.1 (83.3%) was the most predominant genotype, followed by GII.1, GIV.1, GI.2, GI.3, and GII.3 genotypes. Monthly distribution analysis demonstrated two epidemic peaks from July to December 2015 and February to May 2017. However, no detection peak was observed in 2014 and 2016. Phylogenetic analysis of the complete VP1 nucleotide sequences of these GI.1 strains revealed two major clusters of GI.1 and each of which contained GI.1 strains of both 2015 and 2017. This study suggests that the continuous surveillance of SaV is needed to monitor high genetic diversity in Japanese children with AGE.
Emerging therapy options for IgG4-related disease

ABSTRACT Introduction Awareness of IgG4-related disease (IgG4-RD) is increasing worldwide and specialists are now familiar with most of its clinical manifestations and mimickers. IgG4-RD promptly responds to glucocorticoids and repeated courses are typically used to induce and maintain remission because the disease relapses in most patients. If left untreated, it can lead to organ dysfunction, organ failure and death. Advancement in our understanding of IgG4-RD pathogenesis is leading to the identification of novel therapeutic targets and emerging treatments are now setting the stage for personalized therapies for the future. Areas covered This review focuses on emerging treatment options for IgG4-RD based on our advancing understanding of disease pathophysiology. Research was performed in the English literature on Pubmed and clinicaltrials.gov databases. Expert opinion Glucocorticoids remain the first-line induction treatment for the multi-organ manifestations of IgG4-RD. Alternative immunosuppressive agents for maintaining remission are warranted in order to avoid long-term steroid toxicity, and to offer a more mechanistic and personalized therapeutic strategy. Targeting B and T-lymphocyte activation represents the most promising approach, but randomized controlled trials are eagerly awaited to confirm positive preliminary experiences reported in case series and small cohort studies.
The effect of different rates and forms of sulphur applied on changes of soil agrochemical properties

A three-year field experiment was conducted from 2000 to 2002 in North-East Poland. Each year three sulphur fertilization rates in the form of sulphate (S-SO 4 2- ) and pure (S-S 0 ) sulphur were applied: 40, 80 and 120 kg/ha. In the soil horizon at the depth of 0-40 cm the triple rate of S-SO 4 2- and S-S 0 depressed soil reaction. Acidification of soil caused by S-SO 4 2- became evident already in the first year of the study while that resulting from S-S 0 applica- tion appeared as late as in the third year. The effect of sulphur on soil in the 40-80 cm horizon was irregular. As the sulphur rates increased and the duration of the experiment progressed, sulphates accumulated in soil. In the 0-40 cm soil layer, the increasing rates of sulphur tended to increase the content of N-NH 4 + . In most objects, the NPK + S fertilization, and especially the single S-SO 4 2- treatment, caused an increase in N-NO 3 in both soil layers compared with the NPK fertilized object. The dose of 120 kg/ha S-SO 4 caused a significant increase in the concen- tration of available phosphorus in soil in the 0-40 and 40-80 cm layers.