Miracle-dz/UniFAR-FTUs huggingface dataset:
Transcriptome and metabolome profiling unveils the mechanisms of naphthalene acetic acid in promoting cordycepin synthesis in Cordyceps militaris

Cordycepin, an important active substance in Cordyceps militaris, possesses antiviral and other beneficial activities. In addition, it has been reported to effectively promote the comprehensive treatment of COVID-19 and thus has become a research hotspot. The addition of naphthalene acetic acid (NAA) is known to significantly improve the yield of cordycepin; however, its related molecular mechanism remains unclear. We conducted a preliminary study on C. militaris with different concentrations of NAA. We found that treatment with different concentrations of NAA inhibited the growth of C. militaris, and an increase in its concentration significantly improved the cordycepin content. In addition, we conducted a transcriptome and metabolomics association analysis on C. militaris treated with NAA to understand the relevant metabolic pathway of cordycepin synthesis under NAA treatment and elucidate the relevant regulatory network of cordycepin synthesis. Weighted gene co-expression network analysis (WGCNA), transcriptome, and metabolome association analysis revealed that genes and metabolites encoding cordycepin synthesis in the purine metabolic pathway varied significantly with the concentration of NAA. Finally, we proposed a metabolic pathway by analyzing the relationship between gene–gene and gene–metabolite regulatory networks, including the interaction of cordycepin synthesis key genes; key metabolites; purine metabolism; TCA cycle; pentose phosphate pathway; alanine, aspartate, and glutamate metabolism; and histidine metabolism. In addition, we found the ABC transporter pathway to be significantly enriched. The ABC transporters are known to transport numerous amino acids, such as L-glutamate, and participate in the amino acid metabolism that affects the synthesis of cordycepin. Altogether, multiple channels work together to double the cordycepin yield, thereby providing an important reference for the molecular network relationship between the transcription and metabolism of cordycepin synthesis.
Uncovering the Interplay of Oscillatory Processes During Creative Problem Solving: A Dynamic Modeling Approach

ABSTRACT To solve a new problem, people spontaneously engage multiple cognitive processes. Previous work has identified a diverse set of oscillatory components critical at different stages of creative problem solving. In this project, we use hidden state modeling to untangle the roles of oscillation processes over time as people solve puzzles. Building on earlier work, we further developed analytical methods, such as incorporating source separating techniques and identifying the optimal number of states using cross-validation. We extracted brain states characterized by spatio-spectral topographies from time-resolved EEG spectral powers. The data driven approach allowed us to infer the dynamic, trial-by-trial, state sequences, and provided a comprehensive depiction of how various oscillation components interact recurrently throughout the trial. The properties of the states suggest their dissociable cognitive functions. For example, we identified three states with dominant activation in alpha bands but having distinct spatial distributions. People were differentially engaged in these states depending on the stages (e.g., onset or response) and outcomes of the trials (solved with insight or analysis). The current approach, applicable to many tasks requiring extended trial duration, can potentially reconcile findings from previous EEG studies and drive new hypotheses to further our understanding of the complex creative process.
The mechanism of disc disruption by strongly magnetic accretors

A range of important astrophysical systems consist of a strongly magnetic star accreting material from a surrounding disc. These include young stars in T Tauri systems, magnetic neutron stars in X-ray binaries and strongly magnetic white dwarfs in some cataclysmic variables. In all these objects, the stellar magnetic field disrupts the inner part of the disc, and subsequently channels material on to the star's surface. The interaction between the disc, channelled flow and star affects the spin behaviour of the star and hence the properties and evolution of the system. This paper considers the fundamental problem of how the stellar magnetic field disrupts the disc, in a way consistent with subsequent magnetic channelling of the accretion flow. It is shown that magnetic dissipation, inside the corotation radius, leads to increased central pressure which cannot be balanced by the stellar vertical gravity. The disc expands vertically over a narrow radial region to form an accretion curtain of material channelled by the stellar magnetic field. The increased vertical pressure gradients allow material to surmount the potential barrier associated with reaching the sonic point of the channelled flow and matter can subsequently accrete on to the star. An expression is derived for the disc disruption radius as a function of the stellar rotation rate.
Risk factors of caesarean deliveries in urban–rural areas of Bangladesh

Background and aims The key interest of this research is to identify the causes of the ongoing increasing trends in caesarean section or C-section (CS) deliveries in both urban and rural areas of Bangladesh. Methods This study analyzed all Bangladesh Demographic and Health Survey (BDHS) datasets through Chi-square and z tests and the multivariable logistic regression model. Results CS deliveries were found to be more prevalent in urban than in rural areas of Bangladesh. Mothers above 19 years, above 16 years at first birth, overweight mothers, those with higher educational levels, those who received more than one antenatal care (ANC) visit, fathers having secondary/higher education degrees and employed as workers or in business, and mothers living in wealthy households in the cities of Dhaka, Khulna, Mymensingh, Rajshahi, and Rangpur divisions had a significantly higher likelihood of CS deliveries in urban areas. Contrastingly, mothers with ages between 20 and 39 years, above 20 years at first birth, normal weight/overweight mothers, those with primary to higher level of education, those in the business profession, fathers who also received primary to higher education, mothers who received more than one ANC visit, and those living in wealthy households in Dhaka, Khulna, Mymensingh, Rajshahi, and Rangpur divisions were more likely to have CS deliveries in rural areas. The 45–49 age group mothers had a five times higher likelihood of CS deliveries [odds ratio (OR): 5.39] in urban areas than in rural areas. Wealthy mothers were more likely to be CS-delivered in urban (OR: 4.84) than in rural areas (OR: 3.67). Conclusion The findings reveal a gradual upward alarming trend in CS deliveries with an unequal contribution of significant determinants in urban and rural areas of Bangladesh. Therefore, integrated community-level awareness programs are an urgent need in accordance with the findings on the risks of CS and the benefits of vaginal deliveries in this country.
Transcranial cortico-cortical paired associative stimulation (ccPAS) over ventral premotor-motor pathways enhances action performance and corticomotor excitability in young adults more than in elderly adults

Transcranial magnetic stimulation (TMS) methods such as cortico-cortical paired associative stimulation (ccPAS) can increase the strength of functional connectivity between ventral premotor cortex (PMv) and primary motor cortex (M1) via spike timing-dependent plasticity (STDP), leading to enhanced motor functions in young adults. However, whether this STDP-inducing protocol is effective in the aging brain remains unclear. In two groups of young and elderly healthy adults, we evaluated manual dexterity with the 9-hole peg task before and after ccPAS of the left PMv-M1 circuit. We observed that ccPAS enhanced dexterity in young adults, and this effect was anticipated by a progressive increase in motor-evoked potentials (MEPs) during ccPAS administration. No similar effects were observed in elderly individuals or in a control task. Across age groups, we observed that the magnitude of MEP changes predicted larger behavioral improvements. These findings demonstrate that left PMv-to-M1 ccPAS induces functionally specific improvements in young adults’ manual dexterity and an increase in corticomotor excitability, but altered plasticity prevents the effectiveness of ccPAS in the elderly.
PKCε inhibition prevents ischemia‑induced dendritic spine impairment in cultured primary neurons

Brain ischemia is an independent risk factor for Alzheimer's disease (AD); however, the mechanisms underlining ischemic stroke and AD remain unclear. The present study aimed to investigate the function of the ε isoform of protein kinase C (PKCε) in brain ischemia-induced dendritic spine dysfunction to elucidate how brain ischemia causes AD. In the present study, primary hippocampus and cortical neurons were cultured while an oxygen-glucose deprivation (OGD) model was used to simulate brain ischemia. In the OGD cell model, in vitro kinase activity assay was performed to investigate whether the PKCε kinase activity changed after OGD treatment. Confocal microscopy was performed to investigate whether inhibiting PKCε kinase activity protects dendritic spine morphology and function. G-LISA was used to investigate whether small GTPases worked downstream of PKCε. The results showed that PKCε kinase activity was significantly increased following OGD treatment in primary neurons, leading to dendritic spine dysfunction. Pre-treatment with PKCε-inhibiting peptide, which blocks PKCε activity, significantly rescued dendritic spine function following OGD treatment. Furthermore, PKCε could activate Ras homolog gene family member A (RhoA) as a downstream molecule, which mediated OGD-induced dendritic spine morphology changes and caused dendritic spine dysfunction. In conclusion, the present study demonstrated that the PKCε/RhoA signalling pathway is a novel mechanism mediating brain ischemia-induced dendritic spine dysfunction. Developing therapeutic targets for this pathway may protect against and prevent brain ischemia-induced cognitive impairment and AD.
Adaptive finite element mesh refinement techniques in three-dimensional micromagnetic modeling

Two different methods to adaptively refine tetrahedral finite element meshes are presented. The influence of the mesh refinement on the obtained results of micromagnetic calculations is demonstrated for the case of magnetization patterns in soft magnetic platelets. The specific addition of vertices and finite elements in inhomogeneous regions is used to resolve the magnetic structure on small length scales. A method discussed in detail is the shrinking of finite elements in regions with strong inhomogeneities.
Numerical simulation of flows around two circular cylinders by mesh‐free least square‐based finite difference methods

In this paper, the mesh‐free least square‐based finite difference (MLSFD) method is applied to numerically study the flow field around two circular cylinders arranged in side‐by‐side and tandem configurations. For each configuration, various geometrical arrangements are considered, in order to reveal the different flow regimes characterized by the gap between the two cylinders. In this work, the flow simulations are carried out in the low Reynolds number range, that is, Re=100 and 200. Instantaneous vorticity contours and streamlines around the two cylinders are used as the visualization aids. Some flow parameters such as Strouhal number, drag and lift coefficients calculated from the solution are provided and quantitatively compared with those provided by other researchers. Copyright © 2006 John Wiley & Sons, Ltd.
Quench protection of the Fermilab-built LHC inner triplet quadrupole MQXB

High-gradient quadrupoles (MQXB) are being developed at Fermilab within the framework of the US-LHC Accelerator project for the LHC interaction regions. These 5.5-m-long magnets have a single 70-mm aperture and operate in superfluid helium at a peak gradient of 215 T/m. Magnet quench protection is provided by quench heaters installed on the outer surface of the coil. This paper reports the results of quench protection studies on the first full length MQXB prototype (MQXP01). The measurements from these tests as well as results from the 1.9-m-long model magnet program are combined with computer generated quench simulations to predict the MQXB performance under LHC operating conditions.
Topological structure of the magnetotail as a function of interplanetary magnetic field direction

Magnetic reconnection between the interplanetary magnetic field (IMF) and the geomagnetic field is thought to play a major role in the transfer of solar wind momentum and energy to the magnetosphere. As the angle between the IMF and the geomagnetic field is changed at the bow of the magnetosphere, the topological record of the location of the reconnection region should be recorded in the magnetosheath and on the magnetopause along the flanks of the tail, because the super fast flow freezes strong magnetic gradients formed in the bow reconnection regions into the plasma downstream. In this report, we present results from a three-dimensional, magnetohydrodynamic (MHD), global numerical simulation code for the location of the separatrix between unconnected IMF magnetosheath field lines and reconnected field lines which penetrate the magnetopause and connect to the polar ionosphere. The angle between the IMF direction and the line where the separatrix crosses the magnetopause is shown to be a sensitive function of the IMF clock angle. We also explain how this behavior can be used to derive an approximate relation for the dependence of the cross-polar voltage on the IMF clock angle. We conclude with a note of caution concerning the importance of physical boundary conditions in magnetoplasma simulations.
A Lightweight Network Model Based on an Attention Mechanism for Ship-Radiated Noise Classification

Recently, deep learning has been widely used in ship-radiated noise classification. To improve classification efficiency, avoiding high computational costs is an important research direction in ship-radiated noise classification. We propose a lightweight squeeze and excitation residual network 10 (LW-SEResNet10). In ablation experiments of LW-SEResNet10, the use of ResNet10 instead of ResNet18 reduced 56.1% of parameters, while the accuracy is equivalent to ResNet18. The improved accuracy indicates that the ReLU6 enhanced the model stability, and an attention mechanism captured the channel dependence. The ReLU6 activation function does not introduce additional parameters, and the number of parameters introduced by the attention mechanism accounts for 0.2‰ of the model parameters. The 3D dynamic MFCC feature performs better than MFCC, Mel-spectrogram, 3D dynamic Mel-spectrogram, and CQT. Moreover, the LW-SEResNet10 model is also compared with ResNet and two classic lightweight models. The experimental results show that the proposed model achieves higher classification accuracy and is lightweight in terms of not only the model parameters, but also the time consumption. LW-SEResNet10 also outperforms the state-of-the-art model CRNN-9 by 3.1% and ResNet by 3.4% and has the same accuracy as AudioSet pretrained STM, which achieves the trade-off between accuracy and model efficiency.
New perspective: Symbiotic pattern and assembly mechanism of Cantharellus cibarius-associated bacteria

Cantharellus cibarius, an ectomycorrhizal fungus belonging to the Basidiomycetes, has significant medicinal and edible value, economic importance, and ecological benefits. However, C. cibarius remains incapable of artificial cultivation, which is thought to be due to the presence of bacteria. Therefore, much research has focused on the relationship between C. cibarius and bacteria, but rare bacteria are frequently overlooked, and symbiotic pattern and assembly mechanism of the bacterial community associated with C. cibarius remain unknown. In this study, the assembly mechanism and driving factors of both abundant and rare bacterial communities of C. cibarius were revealed by the null model. The symbiotic pattern of the bacterial community was examined using a co-occurrence network. Metabolic functions and phenotypes of the abundant and rare bacteria were compared using METAGENassist2, and the impacts of abiotic variables on the diversity of abundant and rare bacteria were examined using partial least squares path modeling. In the fruiting body and mycosphere of C. cibarius, there was a higher proportion of specialist bacteria compared with generalist bacteria. Dispersal limitation dominated the assembly of abundant and rare bacterial communities in the fruiting body and mycosphere. However, pH, 1-octen-3-ol, and total phosphorus of the fruiting body were the main driving factors of bacterial community assembly in the fruiting body, while available nitrogen and total phosphorus of the soil affected the assembly process of the bacterial community in the mycosphere. Furthermore, bacterial co-occurrence patterns in the mycosphere may be more complex compared with those in the fruiting body. Unlike the specific potential functions of abundant bacteria, rare bacteria may provide supplementary or unique metabolic pathways (such as sulfite oxidizer and sulfur reducer) to enhance the ecological function of C. cibarius. Notably, while volatile organic compounds can reduce mycosphere bacterial diversity, they can increase fruiting body bacterial diversity. Findings from this study further, our understanding of C. cibarius-associated microbial ecology.
Giant Optical Activity and Negative Refractive Index Using Complementary U-Shaped Structure Assembly

In this paper, a chiral metamaterial (CMM) with complementary U-shaped structure assembly is proposed. The microwave experimental and simulated results of the proposed complementary structure exhibit giant optical activity. The experimental results are in good agreement with the numerical ones. The retrieval results reveal that negative refractive indices for right- handed and left-handed circularly polarized waves could be easily realized due to strong chirality. The mechanism of the chiral behaviors of resonance frequencies will be illustrated by simulated current distributions. Further, the complementary U-shaped structure assembly also exhibits stronger circular dichroism, giant optical activity, and negative index at near-infrared region by simulations.
Physicochemical properties and antioxidant activities of thermally treated poly-floral honey from Chire woreda, Sidamo regional State, Ethiopia

Abstract Honey is a health-giving natural product. Researchers are curious to study the processing mechanisms of honey without harming its quality. This study focused on the effect of thermal treatments on the poly-floral honey obtained from Chire Woreda, Sidamo regional state, Ethiopia. The collected research material was processed with different thermal treatments, and the quality parameters were checked. However, before conducting the experiment a preliminary assessment was conducted in the selected Woreda to determine the exact heating temperature and time committed by the beekeepers. Based on the information generated the research material was thermally treated at a temperature and time of 55 & 95°C for 0.5 h, 1 h, and 2 h respectively. The quality parameters (physicochemical properties, total phenolic, total flavonoid contents, and antioxidant activities) were determined by the standard methods, and the values were compared against the national and international standard limits. JMP pro 13 and origin software were used for statistical analysis. The study revealed that heating honey with a high temperature and prolonged time exhibits a significant effect on the quality. The HMF, free acid, total phenolic, total flavonoid, and antioxidant potential of honey were increased after thermal treatments, but, the moisture, diastase activity, and the sugar contents including reducing and non-reducing were measured with low value when the thermal treatments are increased; and this indicated that thermal treatment has both positive and negative effects on the honey quality. Therefore, identifying the optimum processing time and temperature is very important in maintaining the quality of honey.
Linking gender differences with gender equality: A systematic-narrative literature review of basic skills and personality

There is controversy regarding whether gender differences are smaller or larger in societies that promote gender equality highlighting the need for an integrated analysis. This review examines literature correlating, on a national level, gender differences in basic skills—mathematics, science (including attitudes and anxiety), and reading—as well as personality, to gender equality indicators. The aim is to assess the cross-national pattern of these differences when linked to measures of gender equality and explore new explanatory variables that can shed light on this linkage. The review was based on quantitative research relating country-level measures of gender differences to gender equality composite indices and specific indicators. The findings show that the mathematics gender gap from the PISA and TIMMS assessments, is not linked to composite indices and specific indicators, but gender differences are larger in gender-equal countries for reading, mathematics attitudes, and personality (Big Five, HEXACO, Basic Human Values, and Vocational Interests). Research on science and overall scores (mathematics, science, and reading considered together) is inconclusive. It is proposed that the paradox in reading results from the interrelation between basic skills and the attempt to increase girls’ mathematics abilities both acting simultaneously while the paradox in mathematics attitudes might be explained by girls being less exposed to mathematics than boys. On the other hand, a more nuanced understanding of the gender equality paradox in personality is advanced, in which a gene–environment-cultural interplay accounts for the phenomenon. Challenges for future cross-national research are discussed.