Miracle-dz/UniFAR-FTUs huggingface dataset:
Tachyons, Quanta, and Chaos

It is shown using numerical simulation that classical charged tachyons have several features normally thought to be unique to quantum mechanics. Spin-like self-orbiting helical motions are shown to exist at discrete values for the velocity of the tachyon in Feynman-Wheeler electrodynamics and in normal causal electrodynamics more complex closed orbits also appear to exist. Tunneling behavior of the classical tachyon is observed at classical turning points depending on the angle of incidence. The equations of motion appear to be chaotic and effectively indeterministic when the tachyon crosses its own past light cone. It is argued that self-interacting tachyons moving in a tight helix would behave causally, and that they could be a basis for a hidden variable description of quantum mechanics. A procedure is proposed which could determine the fine structure constant.
DDDT_A_302257 1945..1953

1Department of Nephrology, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, People’s Republic of China; 2Biomedical and Health Informatics, University of Washington, Seattle, WA, USA Purpose: There is currently a lack of studies investigating long-term prognosis and the necessity of further rituximab (RTX) consolidation treatment for minimal change disease (MCD) and focal segmental glomerulosclerosis (FSGS). The aim of this study was to evaluate the efficacy of RTX for these diseases and to investigate whether a consolidation treatment can lower risks of relapse and reinforce long-term remission. Patients and Methods: A retrospective study was conducted. The relapse and remission of 70 patients treated with 1 course of RTX treatment (4 infusions of 375 mg/m2) over a median follow-up time of 27 months (12–60 months) were analyzed. The rates of patients that were able to achieve non-relapse for a duration of 24 months between RTX consolidation therapy and non-consolidation therapy were compared. Results: There were 67 cases (95.71%) of remission and 3 cases (4.29%) of non-remission. The average number of relapses decreased from 3.7±2.5 times before the treatment to 0.8 ±1.8 times after treatment (P <0.001). The average avannual number of relapses decreased from 1.3±1.2 times/year to 0.2±0.3 times/year (P <0.001). The results from the Cox proportional-hazards model showed that the risk of relapse in patients who received RTX nonconsolidation treatment was significantly higher than those with consolidation treatment (odds ratios (OR) 20.9, 95% confidence intervals (CI) OR 5.7–75.7, p<0.001). The 24month relapse-free rate was also significantly higher in patients with consolidation therapy compared with non-consolidation therapy (86.36% vs 25%, p<0.001). No adverse events were recorded. Conclusion: RTX is highly effective in treating MCD and FSGS, and RTX consolidation therapy may be recommended to reinforce long-term remissions.
The CCR4-NOT complex maintains stability and transcription of ribosomal 1 RNA genes by repressing anti-sense transcripts

23 The ribosomal RNA genes (rDNA) in eukaryotes are organized in highly repetitive 24 gene clusters. Each organism maintains a particular number of copies, suggesting that 25 the rDNA is actively stabilized. We previously identified about 700 Saccharomyces 26 cerevisiae genes that could contribute to rDNA maintenance. Here, we further analyzed 27 these deletion mutants with unstable rDNA by measuring the amounts of 28 extrachromosomal rDNA circles (ERCs) that are released as by-products of intra- 29 chromosomal recombination. We found that extremely high levels of ERCs were 30 formed in the absence of Pop2 (Caf1), which is a subunit of the CCR4-NOT complex, 31 important for the regulation of all stages of gene expression. In the pop2 mutant, 32 transcripts from the noncoding promoter E-pro in the rDNA accumulated and the 33 amounts of cohesin and condensin were reduced, which could promote recombination 34 events. Moreover, we discovered that the amount of ribosomal RNA was decreased in 35 the pop2 mutant. Similar phenotypes were observed in the absence of subunits Ccr4 36 and Not4 that, like Pop2, convey enzymatic activity to the complex. These findings 37 indicate that lack of any CCR4-NOT associated enzymatic activity resulted in a severe 38 unstable-rDNA phenotype, related to the accumulation of non-coding RNA from E-pro. 39
CAN INVESTOR SENTIMENT IN SOCIAL MEDIA BE USED TO MAKE INVESTMENT DECISION IN STOCK MARKET?

The development of information technology affects the investor's behavior in stock investment. Thus data in Indonesia Social Media, hold important information to predict the movement of the stock price. Unfortunately, the research about investor sentiment in social media repeatedly using the same methods that focus on the amount of stock return and mainly analyzes the stock market in the US. So, we will use logistic regression to model stock buy/ sell decision using investor sentiment as the predictor. We find that the logistic regression model we developed is not fit, and thus, investor sentiment in Social Media alone cannot be used as the predictor of stock buy/ sell decision. We argue there are five possible reasons why we did not find a significant relationship between investor sentiment and stock return. There are the speed of information diffusion on stock prices, data sources, market structure, market capitalization, and investor sentiment measurement methods.
New Heuristics to Stochastic Dynamic Lot Sizing Problem

Simultaneous consideration of both demand and price uncertainties is not studied extensively in the literature. This problem is mathematically intractable for cases where complex problem structure exists. This study proposes new heuristics that consider demand and purchasing price uncertainties simultaneously. When all the costs are constant over time, this is the classical dynamic lot sizing problem for which the optimal solution can be obtained by the Wagner-Whitin algorithm. Purchasing decisions are made on a rolling horizon basis rather than fixed planning horizon. Well-known Least Unit Cost and Silver-Meal algorithms are modified for both time varying purchasing price and rolling horizon. The proposed heuristic is basically based on a cost-benefit evaluation at decision points. A numerical example is explained for showing how heuristics are working in detail. The aim of study is to enlighten about problem that is taken into account. Key Words : Inventory; Stochastic lot sizing; Rolling horizon; Simulation. ,
E ﬀ ect of Welding Parameters on Friction Stir Welded Ti–6Al–4V Joints: Temperature, Microstructure and Mechanical Properties

: In this study, friction stir welding (FSW) of 2-mm-thick Ti–6Al–4V alloy plates was performed using a newly designed friction tool—and the e ﬀ ect of rotation speed and welding speed on microstructure and mechanical properties of the joints were investigated. A simulation model for FSW temperature ﬁeld calculation was developed, and the e ﬀ ect of rotation speed and welding speed on the temperature ﬁeld was investigated by experimental and numeric methods. The results show that the rotation speed has a dominant e ﬀ ect on peak temperature, while welding speed determines the dwell time of the weld exposed to high temperatures. In addition, the inﬂuence of process parameters on the microstructure of the joints was investigated using optical and scanning electron microscopy. The results revealed that there was a phase transformation in the stir zone during welding. The ﬁnal microstructure of the stir zone was fully lamellar ( α + β ) structure, and the heat a ﬀ ection zone had a bimodal microstructure consisting of prior equiaxed α and lamellar ( α + β ) structure. Both rotation speed and welding speed a ﬀ ect the grain size of the weld. Lower peak temperature with decreasing spindle speed and / or shorter dwell time with increasing feed rate could produce ﬁner grains in the stir zone of the joints, thereby could lead to higher microhardness value and the tensile strength of the joints.
EFFECT OF SEED MYCOFLORA ON INCIDENCE OF FUSARIUM WILT DISEASE IN COTTON GENOTYPES

Thirteen cotton ( Gossypium barbadense L.) genotypes were evaluated for Fusarium-wilt incidence, under greenhouse conditions, in 2008 growing season. The genotypes were divided into 5 distinct groups, i.e. resistant, moderately resistant, moderately susceptible, susceptible, and highly susceptible. The genotypes showed considerable variation in healthy seedlings, which ranged from 0.00% on genotype 491/2002 to 90.08% on genotype 507/2002. A total of 13 fungi were isolated from the nonsterilized seeds of the 13 genotypes. The isolated fungi were Alternaria alternata, Aspergillus flavus, A. niger, Aspergillus sp. , Chaetomium sp. , Cladosporium sp. , Fusarium moniliforme, F. oxysporum, Nigrospora sp. , Penicillium sp. , Rhizopus stolonifer, Stemphylium botryeosum, and Trichoderma sp. Genotypes 27/99 and 72/99 yielded the highest number of fungi (8 fungi), while 31/99 yielded the lowest number (3 fungi). The other genotypes yielded a number of fungi ranged from 4 to 6. Rhizopus stolonifer was the only fungus, which was isolated from all the tested genotypes. The mean percentage of fungal recovery from seeds of the 13 genotypes showed that A. flavus (24.77%), A. niger (60.46%), Penicillium (18.15%), and R. stolonifer (65.38%) were the most dominant fungi isolated from the seeds. Other fungi occurred at frequencies ranged from 0.15 to 9.69%. Data for healthy seedlings (dependent variable) and frequencies of the fungi isolated from the seeds (independent variables or predicators) were entered into a computerized stepwise multiple regression analysis. Using the predicators supplied by stepwise regression, a six-variable model was constructed to predict healthy seedlings. This model showed that the differences in healthy seedlings were due largely to the effects of R. stolonifer, Cladosporium, F. oxysporum, Nigrospora, F. moniliforme, and A. alternata , which collectively accounted for 96.10% of the total variation in healthy seedlings- that is, the total variation in wilt incidence. The model also showed that R. stolonifer followed by Cladosporium were the most important seedborne fungi contributing to the variation in healthy seedlings. As far as we know, the results of the present study demonstrated, for the first time, that seed mycoflora play an important role in modifying the reaction of cotton genotypes to FOV. Therefore, it is suggested that the role of seed mycoflora should be considered more than it has been in the past for understanding the variations, among cotton genotypes, in resistance or susceptibility to Fusarium wilt disease.
Qualitative characterization of phenolic profile of the fruits and leaves of Solanum torvum Swart naturally growing in Côte d’Ivoire of Agronomy and Agricultural Research (IJAAR)

The polyphenol phytochemical constituents have a positive impact on health and in the prevention of various diseases. The current study aimed at qualititative phytochemical analysis of Solanum torvum from Côte d’Ivoire, in order to knowledge phenolic potential of plant for futurs reseachs. The leaves and fruits of Solanum torvum were collected in Daloa province of Côte d’Ivoire, dried, ground to powder and extracted using differents solvents. The dry extract purified was dissolved in methanol and filtered through a Millipore membrane with 0. 22μm porosity. Then, each of extracts was further subjected to TLC and HPLC. Total phenolic and flavonoid contents were evaluated using Folin-Ciocalteu method and aluminium trichloride test, respectively. The results revealed that leaves extracts accumulated significantly higher phenolic content 86.07  1.49mg GAE/g DW and flavonoid content 2.51  0.14mg GAE/g DW than extracts fruits. The chromatography analyse showed eigteen compounds in fruits fraction and twenty compounds in leaves fraction. Chromatography identification conducted on ethyl acetate fraction revealed the presence of phenolics acid, flavonoids and coumaric acid. Most of identified compounds are already were isolated by previous phytochemical investigations on Solanum except arbutin, tannic acid and p-coumaric acid. These major active compounds have various biological activities and play a known role in maintaining good health. The results show Solanum from Côte d’Ivoire have the same abilities as other species in the world. The knowledge of phenolic profile of Solanum torvum from Côte d'Ivoire are very important for their authentication, conservation and utilization of biological resources.
(refereed) - postprint Juniperus

Questions: Natural regeneration is central to plant conservation strategies. Worldwide, many Juniperus species are threatened due to their failure to regenerate. We focus on Juniperus communis in areas of NW Europe where it is declining and ask: what advice is available to land managers on natural regeneration methods, and when applied, how effective has this been? Methods: We synthesise knowledge on the efficacy of management interventions and conditions associated with J. communis regeneration. In field trials, we test interventions where knowledge is lacking. We assess regeneration of J. communis, creation of regeneration microsites and germination of sown seed in response to the interventions. Results: Although J. communis occurs in different habitats, there is consistency in site conditions important for regeneration (unshaded/open, short ground vegetation, disturbed/bare ground, low herbivore pressure). In calcareous grasslands, areas with regeneration are stony/bare or vegetation is short or sparse; in upland acid grasslands and dry heathlands regeneration locations are disturbed areas sometimes with a moss cover. Several interventions (grazing, scarification, turf stripping) can create regeneration conditions. The synthesis identified cattle grazing and ground scarification for further testing on upland acid grasslands. In the resulting field trials, regeneration was rare and recorded on only one cattle grazed site. An exposed moss layer characterised regeneration microsites but there was insufficient evidence that either intervention increased regeneration microsite frequency. Few sown seeds germinated. Conclusions: Different interventions or intensities of these appear to be required depending on habitat type. Broadly, on calcareous grassland intense scarification or soil stripping is needed, while on dry heathlands light scarification is suitable. On upland acid grassland, cattle grazing and ground scarification do not reliably result in regeneration. Creation of favourable mossy regeneration microsites is unlikely following intervention, unless soil fertility is low. Land use change, increased climate warming and pollution are pressures acting on J. communis and may cause habitat loss and altered site conditions (e.g. soil fertility), making it difficult to create regeneration microsites at all J. communis sites. Other constraints on regeneration may operate (e.g. seed predation and low seed viability) and managers should assess population and site potential before undertaking management.
Exposure to febrile temperature modiﬁes endothelial cell response to tumor necrosis factor- a

Goldblum. Exposure to febrile temperature modiﬁes endothelial cell response to tumor necrosis factor- a . J Appl Physiol 90: 90–98, 2001. —Fever is an important regulator of inﬂamma-tion that modiﬁes expression and bioactivity of cytokines, including tumor necrosis factor (TNF)- a . Pulmonary vascular endothelium is an important target of TNF- a during the systemic inﬂammatory response. In this study, we analyzed the effect of a febrile range temperature (39.5°C) on TNF- a -stimulated changes in endothelial barrier function, capacity for neutrophil binding and transendothelial migration (TEM), and cytokine secretion in human pulmonary artery endothelial cells (EC). Permeability for [ 14 C]BSA tracer was increased by treatment with TNF- a , and this effect was augmented by incubating EC at 39.5°C. Treating EC with 2.5 U/ml TNF- a stimulated an increase in subsequent neutrophil adherence and TEM. Incubating EC at 39.5°C caused a 30% increase in TEM but did not modify the enhancement of neutrophil adherence or TEM by TNF- a treatment. Analysis of cytokine expression in EC cultures exposed to TNF- a at either 37° or 39.5°C revealed three patterns of temperature and TNF- a responsiveness. Granu-locyte-macrophage colony stimulating factor (GM-CSF) and interleukin (IL)-8 were not detectable in untreated EC but were increased after TNF- a exposure, and this increase was enhanced at 39.5°C. IL-6 expression was also increased with TNF- a exposure, but IL-6 expression was lower in 39.5°C EC cultures. Transforming growth factor- b 1 was constitutively expressed, and its expression was not inﬂuenced either by TNF- a or exposure to 39.5°C. These data demonstrate that clinically relevant shifts in body temperature might cause important changes in the effects of proinﬂammatory cytokines on the endothelium.
RRU_A_296941 105..110

1Department of Urology, Faculty of Medicine Universitas Padjadjaran, General Hospital Hasan Sadikin Bandung, Indonesia; 2Department of Molecular Genetic Laboratory Universitas Padjadjaran, Bandung City, West Java Province, Indonesia Introduction: The prevalence of hypospadias ranges between 1: 250 to 300 per live birth. Estrogen exposure has been associated with the increasing incidence of hypospadias in humans and a significant relationship between Estrogen Receptor 1 (ESR1) polymorphisms and hypospadias was determined from the previous study. This study aims to determine the proportion of ESR1 polymorphism. Methods: This was a descriptive study aimed to find the incidence of ESR1 gene polymorphism in hypospadias patients visiting the Urology Outpatient Unit of the Hasan Sadikin Bandung Hospital who will undergo hypospadias surgery. Deoxyribonucleic acid (DNA) was performed using foreskin of hypospadias patient during the surgery then being extracted and will be analyzed using polymerase chain reaction (PCR) sequencing. Results: Thirty eight samples of hypospadias were identified, 5 samples were unable to sequence and 33 samples were successfully sequenced using the PCR method. The Pvull ESR1 gene was dominated by the T allele which is a wild-type allele and the genotype containing the T allele, namely TT + TC (57,2%). Normal genotype (TT) were more frequent in distal hypospadias, and Heterozygous polymorphisms (TC) was higher in proximal hypospadias. The ESR1 Xba1 gene polymorphism was dominated by the A allele which is a wild-type allele and the AA + AG genotype (76,1%). Normal genotype (AA) was more frequent in distal hypospadias, and both heterozygous hypospadias (AG) and homozygous hypospadias (GG) were found only in proximal hypospadias. The ESR1 SNP 12 gene polymorphisms were found in the combination of genotypes that played a role, namely GA + AA (81%) and the G allele which is a wild-type allele. Heterozygous polymorphisms (GA) was the most finding genotype and more frequent in proximal hypospadias. Conclusion: ESR1 gene polymorphisms (PvuII, XbaI, and SNP 12) were found in hypospadias patients. ESR1 polymorphisms may correlate with the severity of hypospadias. Further research with a larger sample and better hypospadias grouping is needed to confirm.
Mapping of the OxyR Protein Contact Site in the C-Terminal Region of RNA Polymerase (cid:97) Subunit

The Escherichia coli OxyR protein requires the C-terminal contact site I region of the RNA polymerase (cid:97) subunit for cooperative interaction with and transcription activation at OxyR-dependent promoters, suggesting direct protein-protein contact between OxyR and the C-terminal region of the (cid:97) subunit. To determine the precise location of the OxyR protein contact site(s) in this region, we carried out mutational analysis of the 3 (cid:42) half of E. coli rpoA , the gene encoding the (cid:97) subunit of RNA polymerase. We isolated a number of rpoA mutants defective in oxyR -dependent transcription activation at the E. coli katG promoter. Nucleotide sequence analysis of the rpoA gene from these mutants revealed that the mutations showing clear phenotypes are all clustered at two narrow regions (amino acid residues 265 to 269 and 293 to 300) within the C terminus of the (cid:97) subunit. Reconstituted RNA polymerases containing the mutant (cid:97) subunits were unable to respond to transcription activation in vitro at the katG , ahpC , and oxyX promoters by OxyR. These results suggest that these two regions comprise the contact surfaces on the (cid:97) subunit for OxyR. Several lines of evidence indicate that transcription activa- tion by DNA-binding transcription factors involves a direct protein-protein contact between those factors and RNA poly- merase (1, 13). With RNA polymerases containing mutant (cid:97) subunits with C-terminal truncation, Effect of mutations on UP protein(s). In our systematic mapping of the contact site I region on the (cid:97) subunit, we isolated in this study a set of rpoA mutants defective in OxyR-dependent transcription by random mu- tagenesis of the C-terminal proximal half of the rpoA gene followed by in vivo screening for decreased expression of lacZ under the control of the OxyR-regulated katG promoter. The mutations showing the clear mutant phenotype are clustered at two regions, around amino acid residues 268 to 269 (and 265) and 298 to 299. Mutations with less profound phenotypes were also obtained in the vicinity of the downstream contact site, including residues 293, 294, 300, and 307. The results of in vitro transcription experiments with the reconstituted RNA polymerases containing these mutant (cid:97) subunits are generally in good agreement with the in vivo data. Thus, we concluded that the contact site for OxyR is composed of the two short segments, one residues 265 and 269 and the other be- tween residues 293 and 300. These two segments forming the OxyR contact surface are both located on the hydrophilic side of helix-1 and helix-4, respectively, as analyzed by multidimen-sional heteronuclear magnetic resonance
Subnormal levels of POL g A cause inefﬁcient initiation of light-strand DNA synthesis and lead to mitochondrial DNA deletions and autosomal dominant progressive external ophthalmoplegia

The POLG1 gene encodes the catalytic subunit of mitochondrial DNA (mtDNA) polymerase g (POL g ). We here describe a sibling pair with adult-onset progressive external ophthalmoplegia, cognitive impairment and mitochondrial myopathy characterized by DNA depletion and multiple mtDNA deletions. The phenotype is due to compound heterozygous POLG1 mutations, T914P and the intron mutation c.3104 1 3A > T. The mutant genes produce POL g isoforms with heterozygous phenotypes that fail to synthesize longer DNA products in vitro . However, exon skipping in the c.3104 1 3A > T mutant is not complete, and the presence of low levels of wild-type POL g explains patient survival. To better understand the underlying pathogenic mechanisms, we characterized the effects of POL g depletion in vitro and found that leading-strand DNA synthesis is relatively undisturbed. In contrast, initiation of lagging-strand DNA synthesis is ineffective at lower POL g concentrations that uncouples leading strand from lagging-strand DNA synthesis. In vivo , this effect leads to prolonged exposure of the heavy strand in its single-stranded conformation that in turn can cause the mtDNA deletions observed in our patients. Our ﬁndings, thus, suggest a molecular mechanism explaining how POL g mutations can cause mtDNA deletions in vivo .