Miracle-dz/UniFAR-FTUs huggingface dataset:
Determination of Bisphenol in Indoor Dust Samples by Liquid Chromatography in Combination with Quadrupole Mass Spectrometry (LC-MS/MS)

This study has focused on the development of the method LC-MS/MS to determine 2,2-bis(4-hydroxyphenyl)propane (bisphenol A: BPA) and 4,4’-dihydroxydiphenylmethane (bisphenol F: BPF) in indoor samples by using ultrasonication extraction and solid-phase extraction for preparation. The chromatographic procedure was performed on Kinetex C18 2.1 x 150 mm, 2.6 µm column with mobile phases: 2 mM HCOONH4 in MeOH and H2O:MeOH (90:10,…). The method quantification limits (MQL) of BPA and BPF were 15.0 and 12.0 ng/g, respectively. The mean recoveries were 80.4% for BPA and 93.8% for BPF (RSD<15%). The calibration curve for both BPA and BPF was linear over a concentration range of 1.0 to 500 ng/mL (R2 ≥ 0.999). Twenty-one samples were collected from private houses, laboratories, drug stores, and plastic recycling factories in Hanoi. BPA and BPF were found in dust samples with frequencies of 85.7 and 100%, respectively. Concentrations of BPA and BPF in dust samples were in the ranges of <MQL–2230 ng/g (mean: 626) and <MQL–149,000 ng/g (mean: 14,700), respectively. Based on the measured concentration, the human exposure to bisphenol via indoor dust ingestion was estimated for various age groups. The estimated exposure dose for people working at plastic recycling factories was the highest level (23.6 ng/kg-bw/day) but lower than the oral reference dose by the EPA and the European Food Safety Authority (50 µg/kg-bw/day).
The Relationship Between Electrocardiographic P Wave Parameters and Left Atrial Volume and Volume Indices in Patients with Hypertension

Introduction: This study was designed to evaluate the relationship between left atrial volume index, which is an important indicator of left ventricular diastolic dysfunction, and electrocardiographic parameters such as P wave duration, P wave dispersion (PWDISP), P wave terminal force (PWTF), and P wave peak time (PWPT) in hypertensive patients. Patients and Methods: A total of 58 patients with a diagnosis of hypertension between June 2017 and April 2018 were included in this retrospective study. Age-sex matched 58 healthy subjects constituted the control group. The patients without diastolic dysfunction and stage I diastolic dysfunction were included in the normal left atrial pressure (NLAP) group, while stage II and stage III diastolic dysfunction patients constituted the high left atrial pressure (HLAP) group. Results: The PWDmax, PWDISP, and PWPT which are calculated from the lead DII (PWPTDII) were found to be longer in the group of hypertensive patients (p< 0.05, for all). Electrocardiographic parameters of PWDmax, PWDISP, PWTF, PWPTDII, and PWPTVI were found to be longer in patients with HLAP. Both PWPTVI (p= 0.008 r= 0.395) and PWPTDII (p< 0.001 r= 0.456) were significantly correlated with left atrial volume index. Conclusion: In this study, the relationship between PWPT and diastolic dysfunction was revealed for the first time in the literature. In addition, the PWPT was found to be increased in patients with increased left atrial pressure (LAP). Our findings deserve attention because electrocardiography is an inexpensive and easily accessible diagnostic method that can be used to detect diastolic dysfunction in hypertensive patients.
Effects of Different Concentrations of Ropivacaine Lumbar Plexus-Sciatic Nerve Block on Recovery from Anesthesia, Postoperative Pain and Cognitive Function in Elderly Patients with Femoral Neck Fracture

Objective To investigate the effects of lumbar plexus-sciatic nerve block with different concentrations of ropivacaine on recovery from anesthesia, postoperative pain, and cognitive function in elderly patients with femoral neck fracture. Method A total of 110 elderly patients with femoral neck fractures who were treated in our hospital from January 2020 to January 2022 were selected as the research objects. According to the concentration of ropivacaine, they were divided into low-, medium-, and high-concentration groups (concentrations of ropivacaine were 0.15%, 0.25%, and 0.40%, respectively), with 36, 37, and 37 cases, respectively. Extubation time, anesthesia recovery time, and hospitalization time were recorded. Cognitive symptoms were assessed by the spatial cognitive ability, working memory ability, simple computing ability, and picture recognition ability test. The pain degree of patients was assessed by visual analogue scale (VAS). The occurrence of adverse reactions in patients was recorded. Result There was no significant difference in extubation time, anesthesia recovery time, and hospitalization time among the three groups (P > 0.05). The PCA time of the patients in the high-concentration group was significantly longer than that in the low- and medium-concentration groups. The dosage of sufentanil within 24 hours and total sufentanil in the high-concentration group were significantly lower than those in the low- and medium-concentration groups, and the dosage of sufentanil within 24 hours and total sufentanil in the medium-concentration group was significantly less than that in the low-concentration group (P < 0.05). The cognitive function score for each entry of the three groups 1 d after surgery was lower than that before surgery (P < 0.05); On the 1 day after operation, the cognitive function score for each entry of the patients in the low-concentration group was significantly higher than that in the middle- and high-concentration groups, and the cognitive function score for each entry in the middle-concentration group was significantly higher than that in the high-concentration group (P < 0.05). There was no significant difference in VAS scores between the three groups at 2 h and 8 h after surgery (P > 0.05); 16 h and 24 h after operation, the VAS score of patients in the high-concentration group was significantly lower than that in the low- and medium-concentration groups, and the VAS score in the medium-concentration group was significantly lower than that in the low-concentration ropivacaine group (P < 0.05). The incidence of adverse reactions in the high-concentration ropivacaine group was significantly higher than that in the low- and medium-concentration groups (P < 0.05). Conclusion The middle concentration of ropivacaine has good analgesic and nerve block effects and has less influence on cognitive function and less adverse reactions in elderly patients.
Impact of Refinements to Handling and Restraint Methods in Mice

Simple Summary For laboratory mice, handling methods used for routine husbandry and procedures can cause stress, particularly if tail handling methods are used. We first sought to investigate if there were any measurable impacts of different handling methods when tested in a controlled real-world study. Animals were handled at our breeding site using different methods, and their impacts on handling post-transport to the research site were analysed by animal care staff. We found a clear effect of handling method on technician scores relating to overt signs of stress and how easy they were to handle. Based on this study, the institution implemented a refined mouse handling policy. However, one barrier to the use of non-tail handling methods has been arguments that tail handling is necessary for restraint in mice. With a relatively minor adaptation to the conventional restraint method, we have been able to combine cupping with physical restraint for procedures avoiding any use of the tail. Here we provide data showing that our modified restraint method is associated with reduced signs of aversion in the mice. Together, our findings support the implementation of refined handling policies for mice, and this can include handling for both husbandry and restraint for procedures. Abstract There is increasing evidence that, compared to non-aversive handling methods (i.e., tunnel and cupping), tail handling has a negative impact on mouse welfare. Despite this evidence, there are still research organisations that continue to use tail handling. Here, we investigated handling for routine husbandry by three different methods: tail, cupping and tube in a relevant real-world scenario involving mice bred off-site. After transfer to the destination unit, mice were assessed for overt behaviours associated with anxiety and fear. Mice that experienced tail handling were less easy to handle, were more responsive to the box opening, and scored lower in a hand approach test. One barrier to non-tail handling methods is the current practice of restraining mice by the tail for procedures. We therefore next assessed whether a modified method for restraint that takes the animal from cupping to restraint without the use of the tail was associated with better welfare. This refined restraint method reduced overt signs of distress although we did not find any differences in corticosterone levels or anxiety-related behaviours. These findings suggest that avoiding tail handling throughout the animal’s laboratory experience, including during restraint, benefits their welfare.
The moments of the time of ruin in Sparre Andersen risk models

Abstract We derive formulae for the moments of the time of ruin in both ordinary and modified Sparre Andersen risk models without specifying either the inter-claim time distribution or the individual claim amount distribution. We illustrate the application of our results in the special case of exponentially distributed claims, as well as for the following ordinary models: the classical risk model, phase-type(2) risk models, and the Erlang( $\mathscr{n}$ ) risk model. We also show how the key quantities for modified models can be found.
ANÁLISIS DE LA REGULACIÓN METACOGNITIVA EN ESTUDIANTES DE INGENIERÍA DURANTE EL APRENDIZAJE DE LA RESOLUCIÓN DE PROBLEMAS

La educación en ingeniería promueve que el estudiante sea el actor principal de su aprendizaje, por medio de actividades que potencien la resolución de problemas a través de preguntas, construcción de argumentos y exposición de ideas. Se ha visto que la regulación metacognitiva facilita al estudiante monitorear y controlar su aprendizaje durante la resolución de problemas. La regulación metacognitiva conlleva las habilidades metacognitivas de planeación, monitoreo y evaluación que son importantes predictores del aprendizaje. Para los fines educativos de la ingeniería es importante fomentar el empleo de tareas que permitan al maestro reconocer cómo participa la regulación metacognitiva en el aprendizaje de los estudiantes. Sin embargo, faltan estudios que analicen este constructo mientras los estudiantes de ingeniería aprenden resolución de problemas. En este orden, con la presente investigación cualitativa se ha analizado la regulación metacognitiva de estudiantes de ingeniería mientras aprendían a resolver problemas en la asignatura de simulación de eventos discretos. La metodología fue un caso de estudio único donde un alumno de ingeniería industrial verbalizó sus pensamientos en voz alta mientras aprendía a resolver problemas en la simulación de eventos discretos. El análisis deductivo de los pensamientos en voz alta se dio mediante una taxonomía de actividades metacognitivas construida y validada previamente por los autores. Consecuentemente, la investigación halló patrones del uso de la regulación metacognitiva que permitieron evidenciar cómo el alumno de ingeniería fue un eficiente resolutor de problemas. En particular, en este documento se analizó la participación de las habilidades metacognitivas asociadas a la regulación metacognitiva en el aprendizaje de la resolución de problemas en la simulación de eventos discretos. Estos hallazgos son una fuente documental para que los docentes puedan plantear procesos de enseñanza-aprendizaje en ingeniería con el propósito de fomentar el empleo de la regulación metacognitiva.
Bound statcs in quantum systems with position dependent effective masses

Fil: Plastino, Angel Ricardo. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Centro Cientifico Tecnologico Conicet - La Plata; Argentina. Universidad de Las Islas Baleares. Departamento de Fisica; Espana. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Departamento de Fisica; Argentina
The mean behavior of primes in arithmetic progressions.

Knapowski and Turän [19], p. 24 pointed out in 1964 that the study of discrepancies in the distribution of primes in arithmetic progressions—in contrast to the study of uniformities—was "until recently in such a shape äs if we know on the distribution of primes only that there is an infinity of primes (and even less)". The two series of papers by Knapowski and Turän [11], [12], [13], [14], [15], [16], [17], [18], and [19], [20], [21], [22], [23], [24], help in ciosing this gap. The second series, which is almost solely devoted to consideration of "average preponderance problems" (see also [25]), is of primary interest to us in this paper. The results in this series are heavily dependent on the truth of the generalized Riemann hypothesis (this is inherent in the subject matter), but also are largely dependent on the so-called Haselgrove condition that for an explicit E(b}, 0<E(b)^ l, no L (5, ) function modb vanishes in the domain 0< <1, s = a + it, \t\^E(b). The latter is a serious restriction (given the existing state of knowledge) since the only moduli b known to satisfy the Haselgrove condition are the moduli 3 ̂ b ̂ 12, b = 19, and b = 24 (see, e.g. MR 26 # 368c).
Sentiment Analysis and Emotion Recognition from Speech Using Universal Speech Representations

The study of understanding sentiment and emotion in speech is a challenging task in human multimodal language. However, in certain cases, such as telephone calls, only audio data can be obtained. In this study, we independently evaluated sentiment analysis and emotion recognition from speech using recent self-supervised learning models—specifically, universal speech representations with speaker-aware pre-training models. Three different sizes of universal models were evaluated for three sentiment tasks and an emotion task. The evaluation revealed that the best results were obtained with two classes of sentiment analysis, based on both weighted and unweighted accuracy scores (81% and 73%). This binary classification with unimodal acoustic analysis also performed competitively compared to previous methods which used multimodal fusion. The models failed to make accurate predictionsin an emotion recognition task and in sentiment analysis tasks with higher numbers of classes. The unbalanced property of the datasets may also have contributed to the performance degradations observed in the six-class emotion, three-class sentiment, and seven-class sentiment tasks.
Fractional Oscillations And Mittag-Leffler Functions

The fractional oscillation equation is obtained from the classical equation for linear oscillations by replacing the second-order time derivative by a fractional derivative of order with 1 < < 2 : Using the method of the Laplace transform, it is shown that the fundamental solutions can be expressed in terms of Mittag-Leeer functions, and exhibit a nite number of damped oscillations with an algebraic decay. For completeness we also discuss both the cases 0 < < 1 (fractional relaxation) and 2 < 3 (growing oscillations), showing the key role of the Mittag-Leeer functions.
Assessing infection prevention and control (IPAC) knowledge of tattoo artists of British Columbia

Tattooing has become very popular in the past 30 years. The prevalence of tattoos has increased such that approximately twenty percent of Canadians have at least one tattoo. The Personal Services Establishments (PSEs) industry in BC lacks stringent regulations. Tattoo studios are a significant part of the PSEs industry. Tattooing includes invasive procedures and as such, has the potential for spreading many types of infections. Proper Infection Prevention and Control (IPAC) procedures are required to minimize the risk of infections. The British Columbia Ministry of Health (MoH) guidelines for PSEs provide direction for IPAC, however, these guidelines are not enforceable by Environmental Health Officers. Therefore, the IPAC knowledge of tattoo artists in the absence of stringent regulations and its relationship with various other factors should be assessed to gauge any deficits in knowledge and identify opportunities for education.
Mechanism of SCD Participation in Lipid Droplet-Mediated Steroidogenesis in Goose Granulosa Cells

Stearoyl-CoA desaturase (SCD) is a key enzyme catalyzing the rate-limiting step in monounsaturated fatty acids (MUFAs) production. There may be a mechanism by which SCD is involved in lipid metabolism, which is assumed to be essential for goose follicular development. For this reason, a cellular model of SCD function in goose granulosa cells (GCs) via SCD overexpression and knockdown was used to determine the role of SCD in GC proliferation using flow cytometry. We found that SCD overexpression induced and SCD knockdown inhibited GCs proliferation. Furthermore, ELISA analysis showed that SCD overexpression increased the total cholesterol (TC), progesterone, and estrogen levels in GCs, while SCD knockdown decreased TC, progesterone, and estrogen levels (p < 0.05). Combining these results with those of related multi-omics reports, we proposed a mechanism of SCD regulating the key lipids and differentially expressed gene (DEGs) in glycerophospholipid and glycerolipid metabolism, which participate in steroidogenesis mediated by the lipid droplet deposition in goose GCs. These results add further insights into understanding the lipid metabolism mechanism of goose GCs.
Racial/Ethnic Differences in the Pharmacokinetics of Antipsychotics: Focusing on East Asians

Empirical clinical studies have suggested that East Asian patients may require lower dosages of psychotropic drugs, such as antipsychotics, lithium, and antidepressants, than non-Asians. Both the pharmacokinetic and pharmacodynamic properties of a drug can affect the clinical response of an illness. The levels of antipsychotics used for the treatment of schizophrenia may affect patient clinical responses; several factors can affect these levels, including patient medication adherence, body weight (BW) or body mass index, smoking habits, and sex. The cytochrome P450 (CYP) system is a major factor affecting the blood levels of antipsychotics because many antipsychotics are metabolized by this system. There were notable genetic differences between people of different races. In this study, we determined the racial or ethnic differences in the metabolic patterns of some selected antipsychotics by reviewing therapeutic drug monitoring studies in East Asian populations. The plasma concentrations of haloperidol, clozapine, quetiapine, aripiprazole, and lurasidone, which are metabolized by specific CYP enzymes, were determined to be higher, under the same daily dose, in East Asian populations than in Western populations.
Functionalization with Polyphenols of a Nano-Textured Ti Surface through a High–Amino Acid Medium: A Chemical–Physical and Biological Characterization

The study aimed to identify an effective mechanism of adsorption of polyphenols on a nano-textured Ti surface and to evaluate the osteogenic differentiation on it. The source of polyphenols was a natural extract from red grape pomace. A chemical etching was used to form an oxide layer with a nanoscale texture on Ti; this layer is hydrophilic, but without hydroxyl groups with high acidic–basic chemical reactivity. The samples were characterized by electron and fluorescence microscopies, UV–Vis spectroscopy, contact angle measurements, zeta potential titration curves, and Folin–Ciocâlteu test. The presence of an adsorbed layer of polyphenols on the functionalized surface, maintaining redox ability, was confirmed by several tests. Consistent with the surface features, the adsorption was maximized by dissolving the extract in a high–amino acid medium, with respect to an inorganic solution, exploiting the high affinity of amino acids for polyphenols and for porous titanium surfaces. The osteogenic differentiation was assessed on an osteoblastic cell line by immunofluorescence, cell viability, expression of key osteoblast markers, and extracellular matrix mineralization. The surfaces functionalized with the extract diluted in the range 1 × 10−5–1 mg/mL resulted in having a greater osteogenic activity for the highest concentration, with lower values of cell viability; higher expression of alkaline phosphatase, bone sialoprotein, and collagen; and lower levels of osteopontin. In conclusion, the functionalization of a nano-textured Ti surface with polyphenols can potentially favor the osteogenic activity of osseointegrated implants.
Horseracing as gendered leisure events: doing and redoing masculinities in Mexico

ABSTRACT Most research on equestrian sports, including horseracing, has been developed in contexts in the Global North. This has led to a narrow perspective of what horseracing is and means in different historical and sociocultural contexts. This paper extends this reach through considering informal horseracing events in Mexico. Based on understanding gender as a ‘doing’ rather than a ‘being’, and as an integral part of all social practices and identities, the races are examined as leisure events that function as sites through which masculinities are performed and (re)produced. Drawing on an ethnographic study, the horseracing events are identified as spaces in which male-male interactions provide opportunity for men to perform culturally hegemonic norms of masculinity, against a backdrop of shifting economic and social practices that are affecting wider gender relations in Mexico. Although women also have a presence in horseracing, they play a marginal role within the events which celebrate and foreground male homosociality. Masculinities are performed and validated predominantly through male-male interactions and expressions of male dominance over the horses. This paper thus illustrates the importance of gender to understanding different leisure practices and the significance of social and cultural context to examining leisure generally and equestrian sports specifically.
Risk of Cardiovascular Implantable Electronic Device Infection in Patients Presenting With Gram-Negative Bacteremia

Abstract Background Gram-negative bacteremia (GNB) as a manifestation of cardiovascular implantable electronic device (CIED) infection is uncommon. Moreover, echocardiography may be nonspecific in its ability to differentiate whether CIED lead masses are infected. We aimed to determine the rate of CIED infection in the setting of GNB. Methods All patients with CIED who were hospitalized with GNB during 2012–2019 at Mayo Clinic were investigated. The definition of CIED infection was based on criteria recommended by the 2019 European Heart Rhythm Association document. Results A total of 126 patients with CIED developed GNB. None of them had signs of pocket infection. Twenty (15.9%) patients underwent transesophageal echocardiography. Overall, 4 (3%) patients had definite CIED infection. None of them underwent CIED extraction; 3 died within 12 weeks and 1 received long-term antibiotic suppression. Ten (8%) patients had possible CIED infection; despite no CIED extraction, no patient had relapsing GNB. We observed a higher rate of CIED infection in patients with Serratia marcescens bacteremia as compared to that in patients with other GNB. Conclusions The rate of CIED infection following GNB was relatively low. However, accurate classification of CIED infection among patients presenting with GNB remains challenging, in part, due to a case definition of CIED infection that is characterized by a low pretest probability in the setting of GNB. Prospective, multicenter studies are needed to determine accurate identification of CIED infection among GNB, so that only patients with true infection undergo device removal.