Miracle-dz/UniFAR-FTUs huggingface dataset:
Interpersonal Connectivity Work: Being there with and for geographically distant others

In this paper we ask how interpersonal connectivity can be achieved at a geographic distance. This is in contrast with extant literature that focuses on states of connectivity rather than the work needed to achieve it. We draw on phenomenological ideas of embodiment, presence and distance, in combination with empirical material from an extreme remote work context – telenursing in Australia. The nurses we interviewed triage patients entirely by telephone. We argue that even with low social and technical connectivity, interpersonal connectivity is achievable through skilful work with technology. We explore the work that goes into ‘being there with and for distant others’ by combining the phenomenological concepts of ‘maximal grip’ and ‘intentional arc’ with empirical examples. We propose that interpersonal connectivity is oriented empathetically towards both the other person and agentically towards the joint situation. We thereby develop a conceptual model of interpersonal connectivity work, which argues that distributed workers need to skilfully balance the dualities of freedom/control and nearness/farness to achieve interpersonal connectivity. Achieving and maintaining interpersonal connectivity is an important skill, particularly for leaders who operate in work contexts that are increasingly distributed, flexible and temporary.
Gene dosage manipulation alleviates manifestations of hereditary PAX6 haploinsufficiency in mice

Pharmacological induction of wild-type PAX6 allele improved ocular abnormalities induced by PAX6 haploinsufficiency in mice. Eye-opening treatment for haploinsufficiency Aniridia is a genetic disorder predominantly affecting the eye, caused by PAX6 haploinsufficiency due to mutations in one allele. Patients present vision loss and, in some cases, other systemic abnormalities. Increasing the expression of PAX6 early in life could block the progression of the disease. Now, Rabiee et al. used a pharmacological approach in vitro and in a rodent model of Pax6 haploinsufficiency (Pax6+/−). Through chemical screening, the authors showed that MEK inhibitors could increase PAX6 expression in corneal cells. Treating Pax6+/− mice early in life with the inhibitor reduced eye abnormalities, suggesting that MEK inhibitors might be effective for treating postnatal abnormalities in patients with PAX6 haploinsufficiency. In autosomal dominant conditions with haploinsufficiency, a single functional allele cannot maintain sufficient dosage for normal function. We hypothesized that pharmacologic induction of the wild-type allele could lead to gene dosage compensation and mitigation of the disease manifestations. The paired box 6 (PAX6) gene is crucial in tissue development and maintenance particularly in eye, brain, and pancreas. Aniridia is a panocular condition with impaired eye development and limited vision due to PAX6 haploinsufficiency. To test our hypothesis, we performed a chemical screen and found mitogen-activated protein kinase kinase (MEK) inhibitors to induce PAX6 expression in normal and mutant corneal cells. Treatment of newborn Pax6-deficient mice (Pax6Sey-Neu/+) with topical or systemic MEK inhibitor PD0325901 led to increased corneal PAX6 expression, improved corneal morphology, reduced corneal opacity, and enhanced ocular function. These results suggest that induction of the wild-type allele by drug repurposing is a potential therapeutic strategy for haploinsufficiencies, which is not limited to specific mutations.
Types of Mastectomies and Immediate Reconstructions for Ipsilateral Breast Local Recurrences

Purpose: Ipsilateral-breast-local-recurrence (ILBLR) is a rare event with little data on immediate-breast-reconstruction (IBR). We report post-operative results of different types of mastectomy for ILBLR with or without IBR performed during a period of 40 months in order to analyze post-operative complications as main objective. Methods: We analyzed mastectomies performed for ILBLR after initial breast conservative treatment from January 2016 to April 2019. The characteristics of patients, surgery, complication rate, postoperative hospitalization have been determined. Results: Of the 207 mastectomies, 32.8% had an IBR: 31 nipple-sparing-mastectomy (NSM) and 37 skin-sparing-mastectomy (SSM) with 37 latissimus-dorsi-flap (LDF) IBR and 31 implant-IBR. Few reconstruction was performed for patients with body-mass-index ≥30 (OR = 0.214), infiltrating ductal carcinomas (OR = 0.272) and ASA-3 patients (OR = 0.254). In multivariate analysis, LDF-IBR was more often realized for NSM and for patients with BMI ≥25. The overall complication rate was 37.4%: 45.6 and 33.1% with and without IBR, respectively (p = 0.056). In multivariate analysis, BMI ≥25 (OR 2.02, p = 0.023), IBR (OR 1.9, p = 0.046) and tobacco (OR 2.17, p = 0.055) were correlated with higher risk of complications. There was no difference for Grade 2–3 complications rates for IBR and no IBR, respectively (14.7%: 10/68 and 9.3%: 13/139). In multivariate analysis, overall survival from date of mastectomy for local recurrence was significantly associated with interval time to local recurrence (OR 6.981). Conclusion: Salvage mastectomy and IBR is a good choice for ILBLR, particularly using flap reconstruction. NSM can be considered as a good option in selected patients for ILBLR for NSM and/or LDFR.
Field-Deployed Extruded Seed Pellets Show Promise for Perennial Grass Establishment in Arid Zone Mine Rehabilitation

Current methods of mine rehabilitation in the arid zone have a high failure rate at seedling emergence largely due to limited availability of topsoil and low water-holding capacity of alternative growth substrates such as mining overburden and tailings. Further, seedlings have consistently failed to emerge from seeds sown on the soil surface using traditional broadcasting methods. Seed pellets, formed by extruding soil mixtures and seeds into pellets, can potentially increase soil water uptake through enhanced soil-seed contact and thereby improve seedling emergence. We tested an extruded seed pelleting method in a three-factor field experiment (i.e., different pellet-soil mixtures, organic amendments, and simulated rainfall regimes) in north-western Australia. Given the observed lack of seedling emergence from broadcast seeds, the aims of the experiment were to assess: (i) the use of pellets to promote native seedling emergence and establishment and; (ii) the soil physico-chemical and microbiological changes that occur with this method of rehabilitation. The effects of pellet-soil mixtures, organic amendment, and rainfall regime on seedling emergence and survival of three native plant species suggest trade-offs among responses. Pellets made with a 1:1 blend of topsoil and a loamy-sand waste material had the highest seedling emergence, while 100% topsoil pellets had lower emergence probably because of hardsetting. Triodia pungens (a native grass) survived to the end of the experiment while Indigofera monophylla and Acacia inaequilatera (native shrubs) emerged but did not survive. Adding an organic amendment in the extruded pellet inhibited Triodia seedling emergence but increased soil microbial activity. Overall, extruded pellets made from a 1:1 blend showed promise for the establishment of Triodia seeds and beneficially, incorporates mine waste overburden and lesser amounts of topsoil. Further research is needed to improve pelleting production and to test the applicability of the method at scale, for different species and other ecosystem types.
Applying the Inverse Efficiency Score to Visual–Motor Task for Studying Speed-Accuracy Performance While Aging

Background: The current study examines the relationship between speed and accuracy of performance in a reaction time setting and explores the informative value of the inverse efficiency score (IES) regarding the possibility to reflect age-related cognitive changes. Objectives: To study the characteristics of speed and accuracy while performing psychophysiological tests throughout the lifespan; to examine the speed-accuracy ratio in age groups and to apply IES to discriminative visual-motor reaction task; and to figure out the predictive potential of psychophysiological tests to identify IES values. Methods: We utilize nonparametric statistical tests, regression analysis, and supervised machine learning methods. Results and Conclusion: The examinees under 20 and over 60 years of age share one tendency regarding the speed-accuracy ratio without speed-accuracy trade-off. Both at the time of active developmental changes in adolescence and during ongoing atrophic changes in elderly there is a tendency toward a rise of the number of mistakes while slowing the reaction. In the age range from 20 to 60 the relationship between the speed and accuracy is opposite and speed-accuracy trade-off is present. In our battery, complex visual-motor reaction is the only test with the significant negative association between reaction time and error rate in the subcohort of young and midlife adults taken together. On average, women perform more slowly and accurately than men in the speed-accuracy task, however most of the gender-related differences are insignificant. Using results of other psychophysiological tests, we predicted IES values for the visual-motor reaction with high accuracy (R2 = 0.77 ± 0.08; mean absolute error / IES range = 3.37%). The regression model shows the best performance in the cognitively preserved population groups of young and middle-aged adults (20–60 years). Because of the individual rate of neurodevelopment in youth and cognitive decline in the elderly, the regression model for these subcohorts has a low predictive performance. IES accounts for different cognitive subdomains and may reflect their disproportional changes throughout the lifespan. This encourages us to proceed to explore the combination of executive functioning and psychophysiological test results utilizing machine learning models. The latter can be designed as a reliable computer-aided detector of cognitive changes at early stages.
Self-Reported Illicit Drug Use Among Norwegian University and College Students. Associations With Age, Gender, and Geography

Background and Aims: Several studies have pointed to relatively high levels of illicit drug use among students in higher education compared to the general population. The aim of the present study was to provide an updated examination of self-reported illicit drug use among Norwegian University and college students. Methods: Data stem from the SHoT study (Students' Health and Well-being Study), a nationwide cross-sectional survey for higher education in Norway including Norwegian full-time students aged 18–35. Self-reported illicit drug use across a range of specified drugs comprised the outcome variables. Information on gender, age, and study location (geographical area) was also collected and used as stratification variables. The SHoT-survey from 2018 (N = 50,054) was used for the analyses of associations between demographical variables and illicit drug use, while trends in illicit drug use were estimated by comparing the 2018-results with data from the SHoT-surveys conducted in 2010 and 2014. Results: The proportion of students reporting having ever tried illicit drugs increased from 2014 to 2018, for both males (30.8 vs. 36.7%) and females (17.5 vs. 24.0%, both p < 0.001), while only minimal changes occurred between 2010 and 2014. The most commonly used illicit drugs during the past 12 months in 2018 were cannabis (15.2%), followed by MDMA (4.0%), cocaine (3.0%), and LSD/psilocybin (2.1%). Illicit drug use showed both linear increase with age, and inverted U-shaped relationships that peaked in the age span from 23 to 28 years of age. Males reported higher illicit drug use compared with females for all drugs. Proportions of illicit drug use varied across geographical areas within the country, with the highest use being reported in the Oslo area (the largest city and capital of Norway). Conclusions: The present study reports an increase from 2010 to 2018 among Norwegian University and college students in the proportion of those reporting to have tried illicit drugs. Despite varying proportions of use across type of drug, age, gender, and geographical location, the overall high levels of illicit drug use past 12 months confirm the need to address illicit drug use in this population.
Design, Validation, and Reliability of an Observational Instrument for Technical and Tactical Actions in Singles Badminton

Technical and tactical actions are decisive in terms of badminton player competitive performance. The main objective of this research was to design, validate, and estimate the reliability of an observational instrument for the analysis of the tactical and technical actions in individual badminton. The process was carried out in four different steps: first, there was a review of the scientific literature and a preliminary list of variables was made; second, a qualitative and quantitative assessment was completed by 10 badminton expert judges; in the third step, the content validity was estimated using Aiken’s V coefficient; finally, intra-observer reliability and interobserver reliability were tested by two observers specialized in badminton using the Cohen’s Kappa coefficient and the intraclass correlation coefficient. Strokes were used as the unit of measure by our observational instrument; every time badminton players hit the shuttlecock, 22 variables (eight contextual variables, seven variables related to the result of the match, and seven variables related to the game) are observed. The minimum Aiken’s value was 0.58, and reliability was 0.63. In spite of these values, none of the variables had to be removed, but there were modifications in terms of drafting in some of them. The main findings confirmed the validity and the usefulness of this instrument.
Dietary Lysine Regulates Body Growth Performance via the Nutrient-Sensing Signaling Pathways in Largemouth Bass (Micropterus salmoides)

Lysine is known to be a functional nutrient from yeast to human beings. However, the mechanisms for lysine to regulate body growth and metabolism in fish species are far from fully illuminated. In order to elucidate the molecular effects of lysine on growth performance and metabolism, largemouth bass (Micropterus salmoides), which is extremely sensitive to protein composition, was chosen as the experimental model. Juvenile largemouth bass (4.16 ± 0.02 g) were fed with the lysine control diet (LC diet), the lysine supplementation diet (LS diet), and the low lysine diet (LL diet) for 8 weeks. The results showed that the LS diet group significantly increased fish growth, feed efficiency, and nutrient retention compared with those of the LL diet group in largemouth bass. Moreover, compared to the LL diet, lysine supplementation also elevated the plasma total protein, total EAA, total AA, and some individual AA concentrations. Mechanistically, lysine supplementation had a significant effect to decrease the mRNA expression levels of peptide and AA transporters induced by lysine restriction. Lysine supplementation also had an important impact on regulating the target of rapamycin (TOR) signaling pathway. More importantly, the key regulators in the amino acid response (AAR) signaling pathway were also down-regulated by lysine supplementation. Our results provide a clear elucidation of how dietary lysine affected growth performance, physiological and biochemical responses, and signaling responses and represent a sound foundation for using lysine to improve the nutrient utilization of poultry by-product meal in largemouth bass.
Further vocal evidence for treating the Bahama Nuthatch Sitta (pusilla) insularis as a species

Summary. The case for recognising Bahama Nuthatch Sitta insularis as a species separate from Brown-headed Nuthatch S. pusilla has been made several times since 2004, based on plumage, morphometrics, voice and genetic distance, but only one of four world lists currently accepts it as such. We assembled three new sets of recordings and recently published evidence on playback responses. We found that S. insularis has at least five vocalisations that are homologous to but always much higher pitched (by 2–3 kHz) than those of S. pusilla, such that the main calls of the latter are strikingly different from those of the former, and playback studies all suggest a consistently weak response in one species to the calls of the other. Moreover, genetic divergence of insularis from mainland pusilla is greater than that of another Bahamian taxon, Bahama Warbler Setophaga flavescens, recently accepted by all world lists as a species, from mainland Yellow-throated Warbler S. dominica. Taken together with the notably larger bill of Sitta insularis, these factors reinforce the case for treating Bahama Nuthatch as a (regrettably now almost certainly extinct) species.
The Relationship Between Psychological Well-Being and Autonomy in Young People According to Age

Psychological well-being manifests itself in all aspects of human activity and is essential to understanding whether young people experience life satisfaction and whether, as they mature, well-being can be associated with different levels of personal autonomy. This quantitative study was developed within the framework of international research on young people’s autonomy in the transition to adulthood. Its main objectives were to analyze the relationship between psychological well-being and autonomy and examine potential variations between the two variables according to age. To this end, Ryff’s Psychological Well-Being Scale and the Transition to Adulthood Autonomy Scale (EDATVA) designed by Bernal et al., were used with a sample of 1,148 young people aged 16–21 from Madrid, Spain, and Bogotá, Colombia. The results show that almost all the dimensions on the Psychological Well-Being Scale correlate significantly and positively with the dimensions on the EDATVA scale. Specifically, moderate correlations were obtained between self-organization on the EDATVA scale and purpose in life (r = 0.568; p = 0.01) and environmental mastery (r = 0.447; p = 0.01) on the Psychological Well-Being Scale. In turn, autonomy on Ryff’s scale obtained the highest correlation (r = 0.382; p = 0.01) with understanding context on the EDATVA scale. It was also found that the older 18–21 age group obtained higher scores than the younger 16–17 age group in all dimensions on both the EDATVA and the Psychological Well-Being Scale. Earlier studies endorse the results found in this research, especially the differences in the scores for both scales according to age groups. This opens avenues for future research to analyze the relationship between psychological well-being and autonomy as independent variables in other sectors of the population.
Has Stratospheric HCl in the Northern Hemisphere Been Increasing Since 2005?

Stratospheric hydrogen chloride (HCl) is the main stratospheric reservoir of chlorine, deriving from the decomposition of chlorine-containing source gases. Its trend has been used as a metric of ozone depletion or recovery. Using the latest satellite observations, it is found that the significant increase of Northern Hemisphere stratospheric HCl during 2010–2011 can mislead the trend of HCl in recent decades. In agreement with previous studies, HCl increased from 2005 to 2011; however, when the large increase of stratospheric HCl during 2010–2011 is removed, the increasing linear trend from 2005 to 2011 becomes weak and insignificant. In addition, the linear trend of Northern Hemisphere stratospheric HCl from 2005 to 2016 is also weak and insignificant. The significant increase of HCl during 2010–2011 is attributed to a strong northern polar vortex and a weakened residual circulation, which slowed down the transport of HCl between the low-mid latitudes and the high latitudes, leading to an accumulation of HCl in the middle latitudes of the stratosphere. In addition, a weakened residual circulation leads to enhance conversion of chlorine-containing source gases of different lifetimes to HCl, thus increasing the levels of HCl. Simulations by both chemistry transport and chemistry-climate models support the result. It is further found that the joint effect of a La Niña event, the west phase of the quasi-biennial oscillation and positive anomalies of sea surface temperature in the North Pacific is responsible for the strong northern polar vortex and a weakened residual circulation.
Antibiotic resistance and persistence—Implications for human health and treatment perspectives

Antimicrobial resistance (AMR) and persistence are associated with an elevated risk of treatment failure and relapsing infections. They are thus important drivers of increased morbidity and mortality rates resulting in growing healthcare costs. Antibiotic resistance is readily identifiable with standard microbiological assays, and the threat imposed by antibiotic resistance has been well recognized. Measures aiming to reduce resistance development and spreading of resistant bacteria are being enforced. However, the phenomenon of bacteria surviving antibiotic exposure despite being fully susceptible, so‐called antibiotic persistence, is still largely underestimated. In contrast to antibiotic resistance, antibiotic persistence is difficult to measure and therefore often missed, potentially leading to treatment failures. In this review, we focus on bacterial mechanisms allowing evasion of antibiotic killing and discuss their implications on human health. We describe the relationship between antibiotic persistence and bacterial heterogeneity and discuss recent studies that link bacterial persistence and tolerance with the evolution of antibiotic resistance. Finally, we review persister detection methods, novel strategies aiming at eradicating bacterial persisters and the latest advances in the development of new antibiotics.
Gene Editing and Genotoxicity: Targeting the Off-Targets

Gene editing technologies show great promise for application to human disease as a result of rapid developments in targeting tools notably based on ZFN, TALEN, and CRISPR-Cas systems. Precise modification of a DNA sequence is now possible in mature human somatic cells including stem and progenitor cells with increasing degrees of efficiency. At the same time new technologies are required to evaluate their safety and genotoxicity before widespread clinical application can be confidently implemented. A number of methodologies have now been developed in an attempt to predict expected and unexpected modifications occurring during gene editing. This review surveys the techniques currently available as state of the art, highlighting benefits and limitations, and discusses approaches that may achieve sufficient accuracy and predictability for application in clinical settings.
Fine-tuning Neural Machine Translation on Gender-Balanced Datasets

Misrepresentation of certain communities in datasets is causing big disruptions in artificial intelligence applications. In this paper, we propose using an automatically extracted gender-balanced dataset parallel corpus from Wikipedia. This balanced set is used to perform fine-tuning techniques from a bigger model trained on unbalanced datasets to mitigate gender biases in neural machine translation.