Miracle-dz/UniFAR-FTUs huggingface dataset:
Neuroendocrine Carcinomas of the Stomach: Computed Tomography and Pathologic Findings in 32 Patients

Background: Neuroendocrine carcinomas (NECs) of the stomach are poorly diﬀerentiated, high-grade endocrine tumors, including small cell and large cell carcinomas. They are deeply invasive and metastatic, with a poor prognosis. The purpose of this study is to describe the computed tomography (CT) ﬁndings of gastric NECs with pathologic features. Patients and Methods: CT examinations of 32 patients with gastric NECs from January 2004 to January 2015 were reviewed retrospectively for tumor morphology, size, and CT attenuation. CT attenuation of the lymph nodes, peritumoral inﬁltration, and associated ﬁndings, such as liver metastasis and peritoneal carcinomatosis were also reviewed. The ages of patients ranged from 45 to 79 years (mean: 62 years). Twenty-seven patients (84%) were men. Pathologic diagnosis was made using gastrectomy (n = 28) and endoscopic biopsy (n = 4). Nineteen patients underwent multidetector CT with water as an oral contrast agent, and 13 patients underwent helical CT with water. Results: Among the three CT morphologic types of gastric NEC (polypoid, ulcerofungating, and ulceroinﬁltrative), 63% of those in our study were ulcerofungating (n = 20), 37% were ulceroinﬁltrative, and none were polypoid. All were larger than 5 cm in the greatest diameter (mean size: 7.8 cm). The characteristic features at presentation were focal (n = 3) or diﬀuse (n = 15) low attenuation within the mass, extensive low attenuation lymphadenopathy (n = 13), and liver metastasis (n = 6). There were no signiﬁcant diﬀerences between the small cell (n = 10) and the large cell NEC groups (n = 22). Conclusion: Although diﬀerential diagnosis between gastric adenocarcinoma and gastric NEC is diﬃcult, gastric NEC should be considered when CT shows a large ulcerofungating tumor with low attenuation areas (pathologically mucinous or necrotic), espe-cially combined with extensive necrotic lymphadenopathy and frequent hepatic metastases.
A rare case of primary leiomyosarcoma of thyroid in a young adult with literature review

Primary leiomyosarcoma of the thyroid gland (PLT) is an extremely rare neoplasm and still rarer is its occurrence in younger age group. It is one of the most aggressive malignancies with high metastasizing potential. They can be difficult to diagnose on histopathology and can mimic anaplastic or medullary thyroid carcinoma. Only 22 cases of PLT have been reported in the literature and the youngest patient was a 39 years old male. However we report a case of PLT in a 23 years male, being the youngest patient reported till date (23 rd in series). He presented with progressively increasing anterior neck swelling since two months and underwent total thyroidectomy. Histopathology and immunohistochemistry showed features suggestive of leiomyosarcoma of the thyroid gland. Two months later, the tumour recurred at subglottis for which he underwent total laryngo-pharyngectomy followed by radiotherapy. Patient was on regular follow up for one and half year with no recurrence and lost to follow up later.
Epidemiological trend of malaria from 2007 TO 2012 in a tertiary care centre of Kerala- A cross sectional study

India represents the highest burden of malaria in South East Asia Region. But Kerala is a low endemic area. As there were an increased number of cases recently, a cross sectional study was done to evaluate the epidemiological trend of malaria reported from 2007 to 2012 in a tertiary care centre of Kerala. Secondary data available in the Department of Community Medicine, Government Medical College Thrissur, analysed using SPSS 17. A total of 204 cases were reported during the period. Majority was males (94.1%) and in the productive age group. 26 (12.7%) cases were indigenous over these years. All others were imported. Relapse was present in 14.7% patients. Regarding the parasites, 64.9% (n=133) were of Plasmodium vivax type followed mixed and Plasmodium falciparum. As there are favorable climatic conditions to the transmission of malaria most of the time, the re-emergence of malaria should be controlled to prevent massive epidemics.
Mental Health and Peer Support Services Co-located in Substance Use Disorder Treatment Facilities in the United States

Substance use disorders (SUDs) often co-occur with other psychiatric disorders. Over 40% of individuals with SUD in a nationally-representative survey had co-occurring disorders (COD), that is, they met criteria for SUD as well another psychiatric disorder in the past year. The SUD treatment system should be ready to encounter and treat COD, as people with COD may be more likely to seek treatment. The purpose of this dissertation was to understand patterns and predictors of COD services provided in specialty SUD treatment facilities. In Chapter 1, we provided an overview of the problem, as well as a review of the data source and methodology used throughout the dissertation. In Chapter 2, we classified specialty SUD treatment facilities in the United States by the patterns of services provided using data from the 2012 National Survey of Substance Abuse Treatment Services (N-SSATS). We used latent class analysis (LCA) to classify facilities based on mental health, peer support, clinical approaches, and primary focus of the facility in the 2012 N-SSATS. We found that a fourclass solution differentiated classes of facilities by probability of providing mental health services and peer support beyond a single indicator of the facility’s primary focus. In Chapter 3, we used a three-step Vermunt-corrected latent class regression to crosssectionally quantify the association between classes of SUD treatment facilities and facilitylevel predictors in 2012. We found that public ownership, hospital location or affiliation, and flexible financing and reimbursement structures were associated with being in a class with co-located mental health services. In Chapter 4, we used LCA to classify facilities in the 2006 and 2010 N-SSATS, and used latent transition analysis to quantify the probability of moving from one class to another over this five-year period. We found that 93% of facilities stayed in the same class over this time period. Of those that transitioned to another class, 66% added co-located mental health services. Finally, in Chapter 5 we provided an
Peer firms’ earnings predictability and pricing efficiency – evidence from IPOs*

We examine the effect of peer firms’ earnings predictability on initial public offering (IPO) underpricing by investigating whether peer firms’ financial characteristics affect IPO pricing and whether the information disseminated by the IPO firm changes product market competition. Analyzing 5,264 IPOs in the 1976–2012 period using data from multiple sources, we find that IPO firms whose peer firms have long-run earnings predictability tend to have lower underpricing compared to those with short-run earnings predictability. Our study makes three central contributions. First, it shows that investors do not consider IPO firms in isolation from their peer firms and that IPO underpricing is highly dependent on peer firms’ earnings characteristics. Second, it demonstrates that the market does not always consider earnings predictability to be a desirable attribute, which has practical implications for regulators and firms. Third, we find that product market competition from peer firms and managerial ability both affect IPO underpricing. These results suggest that investors might interpret short-run peer firms’ earnings predictability as evidence that a majority of the firms in the industry engage in myopic behaviors, while they might interpret long-run peer firms’ earnings predictability as a signal that the majority of firms in the industry have stable cash flows.
Study On Status And Health Of Wetlands In India: A Geographical Analysis

Due to various climatic variations, land of India supports different kind of latitudinal environment of wetlands. But identity of wetlands is under threat due to the encroachment or conversion of these areas by bunch of activities such as rapid rate of urbanization, expanding agriculture land, changing land use pattern due to population pressure, illegal construction. All these factors cause a great ecological, economic and biological threat to wetlands. This paper reviews the preset status and historical development of wetlands in India focusing on threats to wetland areas. This article also grabs the attention of policy makers to take punitive and preventive measure to improve, conserve and protect the health of wetlands because wetlands have lost their status in terms of conservation of water bodies from decades. The paper concentrates to explore the major factors that are accountable for over exploitation of their resources and need of management to protect the uniqueness of wetlands in India.
Effects of hydroalcoholic extract of celery (apium graveolens) seed on blood & biochemical parameters of adult male rats

Targeted research study the effect hydroalcoholic extract of celery (apium graveolens) seed on blood & biochemical parameters of adult male rats. Twenty-four adult male rats, were randomly divided into three equal groups. First group (control) daily drenched with 1 ml of distilled water along the experimental period (30 day), second & third groups (G1& G2) daily drenched with drinking water contain( 50 &100 mg/kg b.w) of hydroalcoholic extract of celery seed, respectively. At the end of experiment, blood samples were obtained from each rate for estimation of hemoglobin concentration ,packed cell volume ,WBC count and RBC count. TG, TC, LDL-c and HDL-c concentrations in blood serum were calculated. The result showed that significant increase (P<0.05) in RBC counts, PCV &Hb concentration in the two treated groups as compared with control group, while the result of WBC count showed non- significant differences (P<0.05) in two treated groups compared with control. The result of (TG, TC & LDL-c) concentrations showed a significant decrease (P<0.05) in two treated groups compared with control group. At the same time, the result of HDL-c concentration showed a significant decrease (P<0.05) in G2 compared with G1 and control groups.
Gender, legitimacy and the local: a study of elected and unelected political representation

This thesis is concerned with gender and legitimacy in political representation. This work contributes to the field of politics and gender, through an in-depth examination of political representation at the local level which is under-researched. The study focuses on elected and unelected local representatives, in a study site where elected women have achieved ‘gender balance’, as in equal numerical representation (50% of the seats) at council level. It analyses their experiences and perspectives, and those of their peers (elected men, and unelected women) in order to identify gender dimensions and explore the concept of legitimacy. It is based on original qualitative data collected using semi-structured interviews with elected and unelected representatives, at the local level. Secondary data collection has been used to supplement the interview data. The research finds that the legitimacy of unelected and elected women in representative positions at the local level is contested; that gender is a factor in the relationships between the representatives and the represented; and that there are gender dimensions which affect the representational work of both elected and unelected women. It also finds that there are dynamic inter-connections between elected and unelected women which enable the representatives to better navigate the complex ‘geometry of representation’ at the local level. The research is important because it contributes to current debates regarding the legitimacy of women as both elected and non-elected representatives, and because it sheds light on gendered dimensions of local level political representation, at a time when ‘gender balance’ and the legitimacy of women in public life, are of contemporary interest.
Self-reported income data: are people telling the truth?

Purpose This paper aims to detect anomalous data in income reports of Argentina, including personal income – from a sample of households – and statements of public officials. Design/methodology/approach A widely known technique in forensic accounting – such as Benford’s Law – is used. The Chi-square test and the absolute mean deviation are used for verification. The databases consulted include the income declared by households in the Permanent Household Survey – for the 2003-2017 period – and the capital declarations of high-ranking public officials – for the period 1999-2017. Findings The results suggest that income reported in the Encuesta Permanente de Hogares do not follow a Benford´s distribution, and the degree of conformity with this decreases significantly between 2007 and 2015 – coincident with the intervention period of the Instituto Nacional de Estadísticas y Censos. Patrimonial statements of public officials present an acceptable level of compliance with Benford’s law, especially among those of the legislative branch (in more than 90% of cases) although to a lesser extent among officials of the executive branch. Practical implications The results suggest that income reports from the Permanent Household Survey, for the period 2007-2015, should be used with reservations because of their possible manipulation. Originality/value During the intervention of the official statistics institute in Argentina (2007-2015), the idea of lack of credibility of its reports has been disseminated. To date, however, there is no empirical evidence to support it related to income.
Bio-oil yield and quality enhancement through fast pyrolysis and fractional condensation concepts

The influence of operating conditions on the yield and quality of bio-oil obtained from black spruce wood mixture was studied using an auger reactor. Fast pyrolysis optimization through response surface analysis was carried out with four variables: pyrolysis temperature, solids residence time, nitrogen flow, and temperature of first stage of condensation. The optimal conditions obtained for bio-oil production were 555°C, 129 s, 6.9 L/min, and 120°C, respectively. The product yields were 38.61 wt. % of biochar, 25.39 wt. % of liquid, and 36.52 wt. % of non-condensable gases. Two liquid products were produced at the exit of the two condensers, following the concept of fractional condensation. The oily phase yield recovered in the first condenser was 10.59 wt. %, with a 16.86 wt. % of moisture content. Physical properties of the oily phase were analyzed and compared with the ASTM standard D7544-12. Qualitative identification of chemical compounds was carried out for the oily phase which helped in pyrolysis optimization for the bio-oil production targeted towards its use as fuel in commercial burners. In addition, the oil produced here is one of the lowest in water and solids content, attributable to the unique feature of auger reactors without the need for additional treatments.
First-line treatment patterns for recurrent and/or metastatic head and neck cancer (R/M HNC) in Europe.

e16016 Background: The first-line treatment of R/M HNC has evolved in recent years with the introduction of many new therapies. The objective of the current patient record-based survey was to investigate the different treatment modalities and combinations used for R/M HNC in Europe. Methods: Between 9/10/09 and 7/12/09, ear, nose and throat, and radiation and medical oncology specialists from France, Germany, Italy and Spain were asked to provide completed record forms for the last 7-10 HNC patients they treated with chemotherapy (CT), a targeted therapy and/or radiotherapy (RT). Raw data were weighted and analyzed using the “Ethnos” reporting system. First-line treatment patterns for R/M disease are reported here, and data for 2009 were compared with data from a similar survey conducted in 2008. Results: 256 physicians provided 2065 patient records. 845 records were for patients with R/M disease, of whom 747 (88%) were given first-line treatment. Of these patients, 557 (75%) received a systemic treatment.
Are our patients using the Internet

Background: Internet use has exploded in the last several years. We currently lack basic information about as to how many of our patients are using online resources and understand little on patients’ goals and objectives. Objective: improve our understanding of our patients' utilization of the Internet Method: We surveyed 247 outpatients to determine the extent of using on-line resources. Results: 82% (95% C.I.) had a computer or access to one; 59% used the Internet to inquire about health information and they spent an hour or less online per day. Forty-nine percent wanted their clinician to advise them on health related specific Internet sites. Conclusions: In this preliminary study, we found high computer availability and Internet utilization (German J Psychiatry, 2001;4:24-28
Axicabtagene Ciloleucel: The First FDA-Approved CAR T-Cell Therapy for Relapsed/Refractory Large B-Cell Lymphoma

Axicabtagene ciloleucel (axi-cel) is an anti-CD19 CAR T-cell therapy that has demonstrated efficacy in relapsed and refractory diffuse large B-cell lymphoma (DLBCL) patients who have had suboptimal responses to conventional therapies. The immune activation that confers the efficacy of axi-cel comes at the price of potentially devastating adverse phenomena: cytokine release syndrome and neurotoxicity. This article serves as an overview of axi-cel, including a review of the available clinical evidence, mechanism of action, and management of some of the unique toxicities of axi-cel.
Student Entrepreneurial Interests that are influenced by Income Expectations, Entrepreneurship Education, and Self Efficacy

Entrepreneurial interest is an indispensable thing for every individual in this era. Entrepreneurial interest to be realized is influenced by various factors such as Entrepreneurship Education, Self-Efficiency, and Income Expectations. Because the presence of entrepreneurial interest will be able to reduce the impact of social inequality in society and can reduce poverty. Then the purpose of this study is to determine the entrepreneurial interest of students who are influenced by Expectations of Income, Entrepreneurship Education and Self-Efficiency. The methodology of this research is quantitative research by involving 137 students taken by purposive sampling technique. Data analysis method with multiple linear regression. The research results are as follows: (1). Income Expectation has a positive effect on entrepreneurial interest, (2). Entrepreneurship Education has a positive effect on interest in entrepreneurship, (3). Self Efficacy has a positive effect on entrepreneurial interest, (4). Income expectations, entrepreneurship education, and self-efficacy together affect entrepreneurial interest by 57.2% and by 42.8% influenced by variables outside the study
Basic design of a biomimetic underwater soft robot with switchable swimming modes and programmable artificial muscles

A biomimetic underwater robot was designed utilizing ionic polymer-metal composite (IPMC) artificial muscles. The actuators were controlled by thermal and electrical inputs, taking advantage of both the shape-memory and electromechanical behavior of the material, to achieve multiple swimming modes in the proposed robot. The design was inspired by the pectoral fish swimming modes, such as stingrays, knifefish, and cuttlefish. The robot was actuated by two soft fins which consisted of multiple embedded IPMC actuators connected with an Eco-Flex membrane. Through electromechanical actuation, a traveling wave was generated on the soft fin. The deformation and the blocking force of the IPMCs on the fin were measured to characterize the actuators. An experimental setup was also designed in a flow channel to measure the thrust force of the robot under different frequencies and traveling wave numbers in a captive state. Experiments determined a peak thrusting force of 12 mN at a frequency of 0.5 Hz and wave number of 1, and twisting deformations of 30° were obtained. Additionally, shape-memory was utilized to change the swimming mode of the robot from Gymnotiform to Mobuliform. The designed underwater robot utilizes IPMC materials with multi-input control, enabling high deformability, with available maneuverability and agility in future studies.
Orogen proximal sedimentation in the Permian foreland basin

The sedimentary fill of peripheral foreland basins has the potential to preserve a record of the processes of ocean closure and continental collision, as well as the long-term (i.e., 107–108 yr) sediment-routing evolution associated with these processes; however, the detrital record of these deep-time tectonic processes and the sedimentary response have rarely been documented during the final stages of supercontinent assembly. The stratigraphy within the southern margin of the Delaware Basin and Marathon fold and thrust belt preserves a record of the Carboniferous–Permian Pangean continental assembly, culminating in the formation of the Delaware and Midland foreland basins of North America. Here, we use 1721 new detrital zircon (DZ) U-Pb ages from 13 stratigraphic samples within the Marathon fold and thrust belt and Glass Mountains of West Texas in order to evaluate the provenance and sediment-routing evolution of the southern, orogen-proximal region of this foreland basin system. Among these new DZ data, 85 core-rim age relationships record multi-stage crystallization related to magmatic or metamorphic events in sediment source areas, further constraining source terranes and sediment routing. Within samples, a lack of Neoproterozoic–Cambrian zircon grains in the pre-orogenic Mississippian Tesnus Formation and subsequent appearance of this zircon age group in the syn-orogenic Pennsylvanian Haymond Formation point toward initial basin inversion and the uplift and exhumation of volcanic units related to Rodinian rifting. Moreover, an upsection decrease in Grenvillian (ca. 1300–920 Ma) and an increase in Paleozoic zircons denote a progressive provenance shift from that of dominantly orogenic highland sources to that of sediment sources deeper in the Gondwanan hinterland during tectonic stabilization. Detrital zircon core-rim age relationships of ca. 1770 Ma cores with ca. 600–300 Ma rims indicate Amazonian cores with peri-Gondwanan or Pan-African rims, Grenvillian cores with ca. 580 Ma rims are correlative with Pan-African volcanism or the ca. 780–560 Ma volcanics along the rifted Laurentian margin, and Paleozoic core-rim age relationships are likely indicative of volcanic arc activity within peri-Gondwana, Coahuila, or Oaxaquia. Our results suggest dominant sediment delivery to the Marathon region from the nearby southern orogenic highland; less sediment was delivered from the axial portion of the Ouachita or Appalachian regions suggesting that this area of the basin was not affected by a transcontinental drainage. The provenance evolution of sediment provides insights into how continental collision directs the dispersal and deposition of sediment in the Permian Basin and analogous foreland basins.
Low-Cost 24 GHz Radar Fabricated on FR-4 PCB

In this study, a 24-GHz frequency modulated continuous wave(FMCW) radar system was designed on an FR-4 board to demonstrate the feasibility of low-cost radar systems. As the FR-4 substrate has a large substrate loss, its thickness was carefully determined considering line loss and radiation efficiency. Additionally, to operate the radar chip in the industrial scientific and medical(ISM) band without using a phase locked loop(PLL), we superposed and used the triangular wave signal of the DAC and proportional to absolute temperature (PTAT) voltages as a VCO tuning voltage. The designed radar has an operating frequency range of 24.02~24.25 GHz, output power of 4 dBm, a total receiver voltage gain of 66 dB, and an antenna gain of 9 dBi. The RF and MCU boards both use FR-4, and the size of the radar module is 4 cm×4.5 cm.