Miracle-dz/UniFAR-FTUs huggingface dataset:
Migratory Engineering of T Cells for Cancer Therapy

Adoptive cell therapy (ACT) and chimeric antigen receptor (CAR) T cell therapy in particular represents an adaptive, yet versatile strategy for cancer treatment. Convincing results in the treatment of hematological malignancies have led to FDA approval for several CAR T cell therapies in defined refractory diseases. In contrast, the treatment of solid tumors with adoptively transferred T cells has not demonstrated convincing efficacy in clinical trials. One of the main reasons for ACT failure in solid tumors is poor trafficking or access of transferred T cells to the tumor site. Tumors employ a variety of mechanisms shielding themselves from immune cell infiltrates, often translating to only fractions of transferred T cells reaching the tumor site. To overcome this bottleneck, extensive efforts are being undertaken at engineering T cells to improve ACT access to solid tumors. In this review, we provide an overview of the immune cell infiltrate in human tumors and the mechanisms tumors employ toward immune exclusion. We will discuss ways in which T cells can be engineered to circumvent these barriers. We give an outlook on ongoing clinical trials targeting immune cell migration to improve ACT and its perspective in solid tumors.
Models of Pulsar Glitches

Radio pulsars provide us with some of the most stable clocks in the universe. Nevertheless several pulsars exhibit sudden spin-up events, known as glitches. More than forty years after their first discovery, the exact origin of these phenomena is still open to debate. It is generally thought that they an observational manifestation of a superfluid component in the stellar interior and provide an insight into the dynamics of matter at extreme densities. In recent years there have been several advances on both the theoretical and observational side, that have provided significant steps forward in our understanding of neutron star interior dynamics and possible glitch mechanisms. In this article we review the main glitch models that have been proposed and discuss our understanding, in the light of current observations.
RELATIVISTIC SIMULATIONS OF BLACK HOLE–NEUTRON STAR COALESCENCE: THE JET EMERGES

We perform magnetohydrodynamic simulations in full general relativity (GRMHD) of a binary black hole–neutron star (BHNS) on a quasicircular orbit that undergoes merger. The binary mass ratio is 3:1, the black hole initial spin parameter a / m = 0.75 ? > (m is the black hole Christodoulou mass) aligned with the orbital angular momentum, and the neutron star is an irrotational Γ = 2 ? > polytrope. About two orbits prior to merger (at time t = t B ? > ), we seed the neutron star with a dynamically weak interior dipole magnetic field that extends into the stellar exterior. At t = t B ? > , the exterior has a low-density atmosphere with a constant plasma parameter β ≡ P gas / P mag ? > . Varying β at tB in the exterior from 0.1 to 0.01, we find that at a time ∼ 4000 M ∼ 100 ( M NS / 1.4 M ⊙ ) ms ? > (M is the total (ADM) mass) following the onset of accretion of tidally disrupted debris, magnetic winding above the remnant black hole poles builds up the magnetic field sufficiently to launch a mildly relativistic, collimated outflow—an incipient jet. The duration of the accretion and the lifetime of the jet is Δ t ∼ 0.5 ( M NS / 1.4 M ⊙ ) ? > s. Our simulations furnish the first explicit examples in GRMHD that show that a jet can emerge following a BHNS merger.
Medicinal Uses, Nutraceutical Potentials and Traditional Farm Production of Bambara Beans and Pigeon Pea

Bambara groundnut (BGN) [Vigna subterranean (L) Verdc] and Pigeon pea [Cajanus cajan (L.) Millspaugh] are grain legume species grown in tropical and subtropical parts of the world. Both legume grains are highly nutritious and have been used as food and medicine for both humans and animals. However, Bambara groundnut and pigeon pea are still highly underutilized and produced in low quantities despite their nutritional benefits. This review examines nutritional properties, medicinal uses, nutraceutical potential and the limitations in the utilization of bambara groundnut and pigeon pea. Scholarly articles and organization white papers were searched for using various word combinations of traditional farm practices, modern agricultural practices, traditional medicinal uses, nutritional composition, biochemical composition, Bambara groundnut and pigeon pea. Bambara groundnut and pigeon pea are popularly used as medicine in many parts of Africa. Both species are rich sources of bioactive compounds and several studies have documented their efficacy against several diseases. Bambara groundnut has been used to treat polymenorrhea, venereal diseases, cataracts, and morning sickness. The stem, leaves, seeds, and roots of pigeon pea plant has been used to treat many diseases in many parts of the world. Bambara groundnut has been found to be a potential dietary probiotic, antioxidant, antibiotic and anticancer. Hypocholesterolemic, anticancer, hepatoprotective, antidiabetic and antimicrobial activities have been documented for pigeon pea as well. However, low yield, unfavourable land tenure systems, unimproved varieties, diseases, and pests are the major constraints of the traditional production of bambara groundnut and pigeon pea. Both legume grain species are important sources of nutrients and they both possess strong potentials to be nutraceutical agents against many diseases including malnutrition. However, advanced and intensive research on pest management, improvement of the traditional landrace cultivars for improved yield and palatability as well as formulation of favourable land tenure policies are recommended for better adoption, utilization and commercialization of bambara groundnut and pigeon pea.
Factors influencing Lithuanian researchers’ use of open access repositories as a publishing channel

The affordances of repositories for scientific information are emphasized in various international and national governmental and research financing documents. However, the researchers do not upload their full-text publications into the repositories as intensively as it is expected. The aim of the paper is to establish which factors and to what extent affect the intention of Lithuanian researchers to use open access repositories as a publication channel. The model of the theory of planned behaviour was employed to better understand the intentions of Lithuanian researchers to deposit their publications to research repositories. A representative questionnaire survey was carried out to collect the data. The 545 respondents of the survey were the Lithuanian researchers who have a doctoral degree and work at Lithuanian state universities or state research institutes. The obtained data were analysed using statistical analysis (correlation). The connections between intention to submit publications to open access repositories and attitudes, perceived norm, perceived control, past open access publishing behaviour, occupational and demographic characteristics were analysed. The study has identified the factors affecting the open access publishing behaviour of Lithuanian researchers and the strength of their influence with regard to it. It was found that the most significant factors which affect Lithuanian researchers’ intention to submit their publications to repositories are perceived norm, perceived control and past open access publishing behaviour. The age and seniority of researchers are also significant. Lithuanian researchers differ from the general context of open access publishing behaviour in that the influence of norms on the intention to submit publications to open access repositories is greater than that of researchers in other countries, and the attitudes, although positive, are less significant. The remaining factors are affecting their publishing behaviour similarly as in the studies from other countries. Lithuanian researchers representing social sciences and humanities are slightly more likely to submit publications to the repositories than researchers representing the natural science, medicine and technology.
Gravity at the horizon: on relativistic effects, CMB-LSS correlations and ultra-large scales in Horndeski's theory

We address the impact of consistent modifications of gravity on the largest observable scales, focusing on relativistic effects in galaxy number counts and the cross-correlation between the matter large scale structure (LSS) distribution and the cosmic microwave background (CMB). Our analysis applies to a very broad class of general scalar-tensor theories encoded in the Horndeski Lagrangian and is fully consistent on linear scales, retaining the full dynamics of the scalar field and not assuming quasi-static evolution. As particular examples we consider self-accelerating Covariant Galileons, Brans-Dicke theory and parameterizations based on the effective field theory of dark energy, using the hi class code to address the impact of these models on relativistic corrections to LSS observables. We find that especially effects which involve integrals along the line of sight (lensing convergence, time delay and the integrated Sachs-Wolfe effect—ISW) can be considerably modified, and even lead to O(1000%) deviations from General Relativity in the case of the ISW effect for Galileon models, for which standard probes such as the growth function only vary by O(10%). These effects become dominant when correlating galaxy number counts at different redshifts and can lead to ∼ 50% deviations in the total signal that might be observable by future LSS surveys. Because of their integrated nature, these deep-redshift cross-correlations are sensitive to modifications of gravity even when probing eras much before dark energy domination. We further isolate the ISW effect using the cross-correlation between LSS and CMB temperature anisotropies and use current data to further constrain Horndeski models. Forthcoming large-volume galaxy surveys using multiple-tracers will search for all these effects, opening a new window to probe gravity and cosmic acceleration at the largest scales available in our universe.
Association between Endothelial Cell-Specific Molecule 1 and Galectin-3 in Patients with ST-Segment Elevation Myocardial Infarction: A Pilot Study

The biomarkers galectin-3 (Gal-3) and endothelial cell-specific molecule 1 (ESM-1) reflect endothelial function and inflammation. As a consequence, they play an important role in both the diagnosis and characterization of ST-segment elevation myocardial infarction (STEMI). However, no prior study has explored the association between ESM-1 and Gal-3 in STEMI patients. This study is aimed at determining the ESM-1 and Gal-3 levels in the serum of STEMI patients and then exploring the correlation between the levels of these two biomarkers and their clinical significance in STEMI patients. The participants were divided into two groups: the ST group comprised 35 hospitalized STEMI patients while the control group comprised 24 people with normal coronary arteries. In all the patients, venous blood was taken from the middle of the antecubital fossa. The serum ESM-1 and Gal-3 concentrations were determined using an enzyme-linked immunosorbent assay. The results revealed that the ESM-1 and Gal-3 levels in the STEMI patients were 1.6 and 2.8 times higher, respectively, when compared with the controls (P < 0.001). Moreover, the ESM-1 and Gal-3 levels exhibited a positive linear correlation (r = 0.758, P < 0.001) in the acute STEMI patients. In conclusion, the ESM-1 and Gal-3 levels were found to be significantly elevated and correlated in the STEMI patients. Thus, combining these two biomarkers of endothelial dysfunction and inflammation might be useful for the diagnosis and assessment of STEMI.
Suzaku view of the Be/X-ray binary pulsar GX 304-1 during Type I X-ray outbursts

We report the timing and spectral properties of Be/X-ray binary pulsar GX 304-1 by using two Suzaku observations during its 2010 August and 2012 January X-ray outbursts. Pulsations at ~275 s were clearly detected in the light curves from both the observations. Pulse profiles were found to be strongly energy-dependent. During 2010 observation, prominent dips seen in soft X-ray ($\leq$10 keV) pulse profiles were found to be absent at higher energies. However, during 2012 observation, the pulse profiles were complex due to the presence of several dips. Significant changes in the shape of the pulse profiles were detected at high energies ($>$35 keV). A phase shift of $\sim$0.3 was detected while comparing the phase of main dip in pulse profiles below and above $\sim$35 keV. Broad-band energy spectrum of pulsar was well described by a partially absorbed Negative and Positive power-law with Exponential cutoff (NPEX) model with 6.4 keV iron line and a cyclotron absorption feature. Energy of cyclotron absorption line was found to be $\sim$53 and 50 keV for 2010 and 2012 observations, respectively, indicating a marginal positive dependence on source luminosity. Based on the results obtained from phase-resolved spectroscopy, the absorption dips in the pulse profiles can be interpreted as due to the presence of additional matter at same phases. Observed positive correlation between cyclotron line energy and luminosity, and significant pulse-phase variation of cyclotron parameters are discussed in the perspective of theoretical models on cyclotron absorption line in X-ray pulsars.
BARS REJUVENATING BULGES? EVIDENCE FROM STELLAR POPULATION ANALYSIS

We obtained stellar ages and metallicities via spectrum fitting for a sample of 575 bulges with spectra available from the Sloan Digital Sky Survey. The structural properties of the galaxies have been studied in detail in 2009 by Gadotti and the sample contains 251 bulges in galaxies with bars. Using the whole sample, where galaxy stellar mass distributions for barred and unbarred galaxies are similar, we find that bulges in barred and unbarred galaxies occupy similar loci in the age versus metallicity plane. However, the distribution of bulge ages in barred galaxies shows an excess of populations younger than ∼4 Gyr, when compared to bulges in unbarred galaxies. Kolmogorov–Smirnov statistics confirm that the age distributions are different with a significance of 99.94%. If we select sub-samples for which the bulge stellar mass distributions are similar for barred and unbarred galaxies, this excess vanishes for galaxies with bulge mass log M < 10.1 M☉, while for more massive galaxies we find a bimodal bulge age distribution for barred galaxies only, corresponding to two normal distributions with mean ages of 10.4 and 4.7 Gyr. We also find twice as much active galactic nuclei among barred galaxies, as compared to unbarred galaxies, for low-mass bulges. By combining a large sample of high-quality data with sophisticated image and spectral analysis, we are able to find evidence that the presence of bars affects the mean stellar ages of bulges. This lends strong support to models in which bars trigger star formation activity in the centers of galaxies.
Late Sarmatian pottery workshop in Nagymágocs–Paptanya

In this study, we present the results of the first scientific analysis of the micaceous-pebbly ceramic material uncovered from the late Sarmatian settlement in Nagymágocs–Paptanya, Hungary. It is noteworthy that 810 micaceous-pebbly ceramic fragments were found in the settlement. In this respect the settlement has outstanding importance among the late Sarmatian sites of the Southern Great Plain. Evidenced by the excavated pottery workshop, the associated pottery kiln, the clay-extracting pits and the ceramic slags and clay pieces found in the objects, there were Sarmatian age pottery activities at Nagymágocs–Paptanya. However, it was debatable, whether the micaceous-pebbly ceramics were produced locally or the finished products were transported to the settlement. The origin of the temper used in the ceramics also raises questions, as the micaceous rock type found in the ceramics is not accessible in the immediate geological environment of the site. 15 sherds were selected for examination both by the conventional typological methods and petrographic microscopic analysis. The ceramic analyses were also supplemented by the petrographic analysis of a gneiss fragment, which was found in the side wall of the pottery workshop. Based on our results, the vessels proved to be the products of the same manufacturing tradition which applied freshly crushed micaceous gneiss tempering (providing both the denominating mica and pebble grains of ceramics). In one case, additional grog tempering was also detected. Exact petrographic relations could not be drawn of the gneiss temper in ceramics and the gneiss fragment found at the workshop. Homogeneity of the micaceous-pebbly pottery at Nagymágocs and the ideal conditions of pottery production at the settlement can indicate that this ceramic type was made locally and the tempering material was transported to the settlement.
THE TWO- AND THREE-POINT CORRELATION FUNCTIONS OF THE POLARIZED FIVE-YEAR WMAP SKY MAPS

We present the two- and three-point real space correlation functions of the five-year Wilkinson Microwave Anisotropy Probe (WMAP) sky maps and compare the observed functions to simulated ΛCDM concordance model ensembles. In agreement with previously published results, we find that the temperature correlation functions are consistent with expectations. However, the pure polarization correlation functions are acceptable only for the 33 GHz band map; the 41, 61, and 94 GHz band correlation functions all exhibit significant large-scale excess structures. Further, these excess structures very closely match the correlation functions of the two (synchrotron and dust) foreground templates used to correct the WMAP data for galactic contamination, with a cross-correlation statistically significant at the 2σ–3σ confidence level. The correlation is slightly stronger with respect to the thermal dust template than with the synchrotron template.
X-shooter reveals powerful outflows in z ∼ 1.5 X-ray selected obscured quasi-stellar objects

We present X-shooter at the Vewry Large Telescope observations of a sample of 10 luminous, X-ray obscured QSOs at z$\sim1.5$ from the XMM-COSMOS survey, expected to be caught in the transitioning phase from starburst to active galactic nucleus (AGN)-dominated systems. The main selection criterion is X-ray detection at bright fluxes (L$>=10^{44}$ erg s$^{-1}$) coupled to red optical-to-NIR-to-MIR colors. Thanks to its large wavelength coverage, X-shooter allowed us to determine accurate redshifts from the presence of multiple emission lines for five out of six targets for which we had only a photometric redshift estimate, with an 80 percent success rate, significantly larger than what is observed in similar programs of spectroscopic follow-up of red QSOs. We report the detection of broad and shifted components in the [OIII]$\lambda\lambda$5007,4959 complexes for six out of eight sources with these lines observable in regions free from strong atmospheric absorptions. The full width half-maximum (FWHM) associated with the broad components are in the range FWHM$\sim900-1600$ km s$^{-1}$, larger than the average value observed in SDSS Type 2 AGN samples at similar observed [OIII] luminosity, but comparable to those observed for QSO/ultraluminous infrared galaxies systems for which the presence of kpc scale outflows have been revealed through integral field unit spectroscopy. Although the total outflow energetics (inferred under reasonable assumptions) may be consistent with winds accelerated by stellar processes, we favour an AGN origin for the outflows given the high outflow velocities oberved (v$>1000$ km s$^{-1}$) and the presence of strong winds also in objects undetected in the far infrared.
Effectiveness and Safety of Sofosbuvir-Velpatasvir in Patients with Cirrhosis Associated with Genotype 3 Hepatitis C Infection in Xinjiang, China

Purpose Patients with cirrhosis from genotype 3 (GT3) hepatitis C virus (HCV) infection are difficult to cure. This study investigated the effectiveness and safety of sofosbuvir-velpatasvir (SOF/VEL) with and without ribavirin (RBV) in patients with GT3 HCV-infection-related cirrhosis from Xinjiang, China. Patients and Methods This study included 33 patients with GT3 HCV infected cirrhosis, who were treated with either SOF/VEL+RBV for 12 weeks (n = 27) or SOF/VEL alone for 24 weeks (n = 6) between January 2019 and June 2021. The primary endpoint was a sustained virological response at 12 weeks (SVR12), post-treatment. Secondary endpoints included changes from baseline in Child-Pugh-Turcotte scores, clinical results, hepatic-encephalopathy status, ascites, and gastrointestinal bleeding at 12 weeks, post-treatment. Results Out of the 33 patients, 18 (54.6%) were diagnosed with GT3a, 15 (45.4%) with GT3b, 16 (48.5%) with compensated cirrhosis, and 17 (51.5%) with decompensated cirrhosis. SVR12 was 87.9% (compensated cirrhosis: 93.8%, decompensated cirrhosis: 82.4%). The Child-Pugh-Turcotte scores improved at 12 weeks (p < 0.05). Total bilirubin, albumin, and alanine transaminase levels, as well as hepatic-encephalopathy were significantly improved among patients with compensated and decompensated cirrhosis (p < 0.05). The blood cell count and serum creatinine levels did not deteriorate. Conclusion SOF/VEL, with and without RBV, was effective, safe, and well-tolerated as a treatment for GT3 HCV associated cirrhosis.
On an integrable discretisation of the Ablowitz-Ladik hierarchy

Following the general results on the relationships about Backlund transformations (BTs) and exact discretisation given in a previous work [12], we consider the Ablowitz-Ladik hierarchy and a corresponding family of BTs. After discussing the boundary conditions, we show how to get explicit transformations. The Hamiltonian properties of the maps and of the discrete flows are examined. The conditions on the parameters of the map giving exact discretisations are discussed. Finally, analytical and numerical examples are given.
Signatures of nonlinear mode interactions in the pulsating hot B subdwarf star KIC 10139564

We analyse 38-month of contiguous short-cadence data, concentrating on mode multiplets induced by the star rotation and on frequencies forming linear combinations that show intriguing behaviors during the course of the observations. We find clear signatures that point toward nonlinear effects predicted by resonant mode coupling mechanisms. These couplings can induce various mode behaviors for the components of multiplets and for frequencies related by linear relationships. We find that a triplet at 5760\,$\mu$Hz, a quintuplet at 5287\,$\mu$Hz and a ($\ell>2$) multiplet at 5412\,$\mu$Hz, all induced by rotation, show clear frequency and amplitude modulations which are typical of the so-called intermediate regime of a resonance between the components. One triplet at 316\,$\mu$Hz and a doublet at 394\,$\mu$Hz show modulated amplitude and constant frequency which can be associated with a narrow transitory regime of the resonance. Another triplet at 519\,$\mu$Hz appears to be in a frequency lock regime where both frequency and amplitude are constant. Additionally, three linear combination of frequencies near 6076\,$\mu$Hz also show amplitude and frequency modulations, which are likely related to a three-mode direct resonance. The identified frequency and amplitude modulations are the first clear-cut signatures of nonlinear resonant couplings occurring in pulsating hot B subdwarf stars. However, the observed behaviors suggest that the resonances occurring in these stars usually follow more complicated patterns than the simple predictions from current nonlinear theoretical frameworks. These results should therefore motivate further work to develop the theory of nonlinear stellar pulsations, considering that stars like KIC~10139564 now offer remarkable testbeds to do so.