Miracle-dz/UniFAR-FTUs huggingface dataset:
ZHX3 promotes the progression of urothelial carcinoma of the bladder via repressing of RGS2 and is a novel substrate of TRIM21

Clinically, patients with urothelial carcinoma of the bladder (UCB) with tumor metastasis are incurable. To find new therapeutic strategies, the mechanisms underlying UCB invasion and metastasis should be further investigated. In this study, zinc finger and homeobox 3 (ZHX3) was first screened as a critical oncogenic factor associated with poor prognosis in a UCB dataset from The Cancer Genome Atlas (TCGA). These results were also confirmed in a large cohort of clinical UCB clinical samples. Next, we found that ZHX3 could promote the migration and invasion capacities of UCB cells both in vitro and in vivo. Mechanistically, coimmunoprecipitation (coIP) and mass spectrometry (MS) analysis indicated that ZHX3 was a target of tripartite motif 21 (TRIM21), which mediates its ubiquitination, and subsequent degradation. Notably, RNA‐seq analysis showed that ZHX3 repressed the expression of regulator of G protein signaling 2 (RGS2). Generally, our results suggest that ZHX3 plays an oncogenic role in UCB pathogenesis and might serve as a novel therapeutic target for UCB.
Optimal Pricing Decisions for a Low-Carbon Supply Chain Considering Fairness Concern under Carbon Quota Policy

This research investigates the effect of fairness concerns on a sustainable low-carbon supply chain (LCSC) with a carbon quota policy, in which a manufacturer is in charge of manufacturing low-carbon products and sells them to a retailer. The demand is affected by price and the carbon emission reduction rate. The optimal decisions of pricing and carbon emission reduction rate are analyzed under four decision models: (i) centralized decision, (ii) decentralized decision without fairness concern, (iii) decentralized decision with manufacturer’s fairness concern, (iv) decentralized decision with retailer’s fairness concern. The results indicate that the profits in the centralized LCSC are higher than those in the decentralized LCSC with fairness concern. If a manufacturer pays close attention to fairness, the fairness concern coefficient will reduce the carbon emission reduction rate and the profit of the LCSC and increase the wholesale price and the retail price of the product. If a retailer pays close attention to fairness, and the preference of consumers for a low-carbon product is low, the fairness concern coefficient of the retailer increases the total profit of the LCSC and decreases the carbon emission reduction rate and retail price of the product. Otherwise, if the preference of consumers for a low-carbon product is great, the fairness concern coefficient of the retailer would lead to a lower retail price compared with the retail price in the centralized decision and decrease the total profit of the LCSC.
Graphene, the new nanocarbon

Graphene is a fascinating new nanocarbon possessing, single-, bi- or few- (≤ ten) layers of carbon atoms forming six-membered rings. Different types of graphene have been investigated by X-ray diffraction, atomic force microscopy, transmission electron microscopy, scanning tunneling microscopy and Raman spectroscopy. The extraordinary electronic properties of single-and bi-layer graphenes are indeed most unique and unexpected. Other properties of graphene such as gas adsorption characteristics, magnetic and electrochemical properties and the effects of doping by electrons and holes are equally noteworthy. Interestingly, molecular charge-transfer also markedly affects the electronic structure and properties of graphene. Many aspects of graphene are yet to be explored, including synthetic strategies which can yield sufficient quantities of graphene with the desired number of layers.
Physical Performance and Cognition in a Diverse Cohort: Kaiser Healthy Aging and Diverse Life Experiences (KHANDLE) Study.

BACKGROUND The authors assessed the cross-sectional association of physical function measures with cognition in the Kaiser Healthy Aging and Diverse Life Experiences Cohort. METHODS Analyses included 1369 participants (24% Asian, 26% Black, 18% Latino, 32% White). Grip strength was measured using a hand-held dynamometer (kilograms) and gait speed was measured over a 4-m walk (seconds/meter). The Spanish and English Neuropsychological Assessment Scales was used to evaluate cognitive domains of executive function, semantic memory, and verbal episodic memory. Physical function measures (per SD) were associated with cognitive test z-scores in linear regression models adjusted for demographic, behavioral, and clinical factors. Racial/ethnic differences were tested using interaction terms and stratification. RESULTS Stronger grip was associated with better executive function [β=0.10 (95% confidence interval, 0.05-0.15)], semantic memory [β=0.13 (0.09-0.18)] and verbal episodic memory [β=0.07 (0.02-0.13)] with no racial/ethnic differences. Faster gait was associated with better executive function [β=0.29 (0.22-0.36)], semantic memory [β=0.23 (0.16-0.30)], and verbal episodic memory [β=0.20 (0.13-0.27)]; however, the association between gait speed and executive function varied by race/ethnicity with the strongest associations in Asians and Whites. CONCLUSION Across race/ethnicity, grip strength and gait speed were associated with cognition with racial/ethnic differences in the association of gait speed and executive function.
Favorite Orientation of the Carbon Cage and a Unique Two-Dimensional-Layered Packing Model in the Cocrystals of Nd@C82(I,II) Isomers with Decapyrrylcorannulene.

To date, the experimental studies on Nd-based metallofullerenes are only limited to spectroscopic characterizations. In this work, the molecular structures of Nd@C82(I,II) isomers, including the isomeric symmetry of the C cage and the position of endohedral Nd atom, as well as their unique two-dimensional (2D)-layered crystallographic packing structures were initially and unambiguously elucidated, based on the X-ray structural analyses of the cocrystals of Nd@C82(I) or Nd@C82(II) with cocrystallizing agent decapyrrylcorannulene (DPC). In the V-shaped unit cell, the endohedral Nd atom prefers a site as far away from the DPC molecules as possible because of the unevenly distributed charge on the C cage mainly related to the charge transfers from the endohedral Nd atom, cocrystallizing agent DPC, and solvent toluene molecules to the C82 cage. Apart from charge transfers, multiple C-H···π intermolecular interactions are also confirmed to play important roles both for the orientation of the C cage correlated with the preferential sites of the endohedral Nd atom and for the 2D-layered packing structures within the cocrystals. Density functional theory computations offered theoretical support for the molecular structures of Nd@C82(I,II) isomers, the valence of the endohedral Nd atom (between II+ and III+), and the global ground state, i.e., the Nd@C2v(9)-C82 isomer in the quintet state.
Perspectives of people accompanying a person during voluntary stopping eating and drinking: a convergent mixed methods study.

BACKGROUND Voluntary stopping eating and drinking (VSED) is an option for people wishing to bring about premature death. In Switzerland, VSED is considered a controversial action at the end of life in the guidelines for "Management of dying and death," which states that the decision to support or oppose VSED must be made individually by health care professionals; so far there are no instructions for action. The aim of this research was to explore the experiences of people who play an important role in VSED accompaniment, and to explain how the people involved in the process deal with VSED. METHODS This convergent mixed methods study included a national survey (n=1,681) and five focus group interviews (n=47). Data integration was conducted using the four-stage pillar integration process. RESULTS Given Swiss society interest, VSED has already established itself in the health system without the institutions having addressed the issue, whereupon health professionals make individual decisions when a person willing to die comes to them with a VSED wish. Health professionals are open to VSED, but are also ambivalent and would like to know more about it before being confronted with a VSED case. CONCLUSIONS In Switzerland, VSED has become a rare but desired option for ending life prematurely. While health professionals are already being confronted with the phenomenon, there is a lack of discussion at the level of health institutions about how to deal with it.
BIRTH WEIGHT AND OVERWEIGHT IN ADOLESCENTS: THE ERICA PROJECT IN THE CITY OF RECIFE, PERNAMBUCO.

OBJECTIVE To verify the association of anthropometric parameters at birth, socioeconomic and biological variables, physical activity, and parental nutritional status with overweight and abdominal obesity in adolescents. METHODS A cross-sectional study was carried out on 39 public and private schools in Recife (state of Pernambuco, Brazil). The sample consisted of 1,081 teenagers aged from 12 to 17 years. Data were collected from the Study of Cardiovascular Risks in Adolescents (ERICA). Body mass index according to age (BMI-for-age), waist circumference (WC), and waist-to-height ratio (WtHR) were considered as outcome variables, whereas the explanatory variables were birth weight, Röhrer's Ponderal Index (RPI), biological and socioeconomic variables, physical activity, and parental nutritional status. The crude and adjusted prevalence ratios (PR) for the studied association were estimated by Poisson Regression. RESULTS The multivariate Poisson regression showed that the variable that remained significantly associated with overweight in adolescence was maternal overweight, PR=1.86 (95% confidence interval [95%CI] 1.09-3.17). High birth weight also remained significantly associated with abdominal obesity assessed by WC, PR=3.25 (95%CI 1.0-9.74). CONCLUSIONS High birth weight may be a marker for abdominal obesity in adolescence; and high maternal BMI, for overweight.
In situ FTIR–attenuated total reflection spectroscopic investigations on the base–acid transitions of polyaniline. Base–acid transition in the emeraldine form of polyaniline

Emeraldine refers to the semi-oxidized state of polyaniline and it can exist in the base form or the protonated form (salt) generated by treatment of the base form with an acid. Using a newly applied doping system NaReO4/HReO4, the investigation of the base–acid transition process of emeraldine has been carried out by ex situ and in situ FTIR spectroscopic methods. In situ FTIR–ATR (attenuated total reflection) measurements performed during the base–acid transition process clearly show the change in the structure of the polymer film observable. The physical properties of emeraldine can be changed considerably by varying the pH of the media. The base form of emeraldine is an insulator and treatment with acidic media results in the highly conducting salt form (proton doping). The protonation of emeraldine starts at pH 6. The intensity of a broad absorption band at wavenumbers higher than 2000 cm–1(0.25 eV) depends strongly on the pH of the electrolyte. This absorption band bleaches completely with increasing pH, indicating a strong correlation between this band and the metallic character of the polymer. On the basis of in situ FTIR–ATR measurements, a reaction path of acid–base transitions has been proposed.
High-Entropy Alloys for Advanced Nuclear Applications

The expanded compositional freedom afforded by high-entropy alloys (HEAs) represents a unique opportunity for the design of alloys for advanced nuclear applications, in particular for applications where current engineering alloys fall short. This review assesses the work done to date in the field of HEAs for nuclear applications, provides critical insight into the conclusions drawn, and highlights possibilities and challenges for future study. It is found that our understanding of the irradiation responses of HEAs remains in its infancy, and much work is needed in order for our knowledge of any single HEA system to match our understanding of conventional alloys such as austenitic steels. A number of studies have suggested that HEAs possess ‘special’ irradiation damage resistance, although some of the proposed mechanisms, such as those based on sluggish diffusion and lattice distortion, remain somewhat unconvincing (certainly in terms of being universally applicable to all HEAs). Nevertheless, there may be some mechanisms and effects that are uniquely different in HEAs when compared to more conventional alloys, such as the effect that their poor thermal conductivities have on the displacement cascade. Furthermore, the opportunity to tune the compositions of HEAs over a large range to optimise particular irradiation responses could be very powerful, even if the design process remains challenging.
Adsorption and Movement of Cypermethrin on Indian Soils Amended with Cationic, Non-Ionic and Anionic Surfactants

Laboratory studies were conducted to determine the adsorption and movement of cypermethrin on surfactant-free (natural) and surfactant-amended soils at different micelle concentrations (below the CMC, at the CMC and above the CMC) using batch equilibrium and soil TLC techniques. The measured equilibrium adsorption isotherms for both surfactant-free and surfactant-amended soils were of type C and in close agreement with the Freundlich isotherm. Higher adsorption of cypermethrin in both types of system was observed on silt loam soil than on sandy loam soil as anticipated by the values obtained for the Freundlich constant, KF, and the partition coefficient, KD. The values of KF and KD confirmed that cypermethrin adsorption on surfactant-amended soils followed the order cationic > non-ionic > anionic under all CMC conditions studied. The KF and KD values also confirmed that cypermethrin adsorption was higher on soils amended with surfactants maintained below the CMC, while lower values of KF and KD confirmed the lower adsorption of cypermethrin on soils amended with both non-ionic and anionic surfactants maintained at or above the CMC value relative to the situation with surfactant-free soils. The higher values of KF and KD showed that the adsorption of cypermethrin increased on soils amended with CTAB when the latter was at or above the CMC value relative to surfactant-free soils. The Rf values obtained from soil TLC studies were inversely proportional to the KF and KD values for both surfactant-free and surfactant-amended soils. The affinity of cypermethrin towards the organic carbon and clay content of the soils was evaluated by calculating the Koc and KD values, when it was found that the affinity of cypermethrin was better correlated with the clay content of the soils than with their organic carbon content. The results obtained are interesting in that they afford basic data resulting to the possible use of surfactants for solving problems of soil contamination posed by cypermethrin.
Analysis of UAV-Acquired Wetland Orthomosaics Using GIS, Computer Vision, Computational Topology and Deep Learning

Invasive blueberry species endanger the sensitive environment of wetlands and protection laws call for management measures. Therefore, methods are needed to identify blueberry bushes, locate them, and characterise their distribution and properties with a minimum of disturbance. UAVs (Unmanned Aerial Vehicles) and image analysis have become important tools for classification and detection approaches. In this study, techniques, such as GIS (Geographical Information Systems) and deep learning, were combined in order to detect invasive blueberry species in wetland environments. Images that were collected by UAV were used to produce orthomosaics, which were analysed to produce maps of blueberry location, distribution, and spread in each study site, as well as bush height and area information. Deep learning networks were used with transfer learning and unfrozen weights in order to automatically detect blueberry bushes reaching True Positive Values (TPV) of 93.83% and an Overall Accuracy (OA) of 98.83%. A refinement of the result masks reached a Dice of 0.624. This study provides an efficient and effective methodology to study wetlands while using different techniques.
Myopericarditis caused by severe acute respiratory syndrome coronavirus 2

A 25-year-old man presented to the emergency department with acute-onset chest pain and shortness of breath. A physical examination revealed coarse crackles in the both lower lungs. Consolidation and ground-glass opacities suggesting viral infection were detected in the right lower lobe on chest computed tomography. Laboratory findings revealed elevated troponin, leukocytosis, and lymphopenia. Electrocardiography revealed ST segment elevation with PR depression in leads I, aVL, V5, and V6, and ST depression and PR elevation in aVR. Echocardiography revealed diffuse cardiac hypokinesia and a decreased left ventricular ejection fraction. Suspecting coronavirus disease 2019 (COVID-19)–related myopericarditis, the patient was hospitalized. After one week of empirical antibiotics, antivirals, and supportive therapy, his condition improved. Antibody testing for COVID-19 was positive on hospitalization day 8. The presentation of myopericarditis can be vague and mislead physicians during the COVID-19 pandemic. Myopericarditis should be included as a differential diagnosis for patients with suspected COVID-19.
Neurologic Syndromes Predict Higher In-Hospital Mortality in COVID-19

Objective Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is protean in its manifestations, affecting nearly every organ system. However, nervous system involvement and its effect on disease outcome are poorly characterized. The objective of this study was to determine whether neurologic syndromes are associated with increased risk of inpatient mortality. Methods A total of 581 hospitalized patients with confirmed SARS-CoV-2 infection, neurologic involvement, and brain imaging were compared to hospitalized non-neurologic patients with coronavirus disease 2019 (COVID-19). Four patterns of neurologic manifestations were identified: acute stroke, new or recrudescent seizures, altered mentation with normal imaging, and neuro-COVID-19 complex. Factors present on admission were analyzed as potential predictors of in-hospital mortality, including sociodemographic variables, preexisting comorbidities, vital signs, laboratory values, and pattern of neurologic manifestations. Significant predictors were incorporated into a disease severity score. Patients with neurologic manifestations were matched with patients of the same age and disease severity to assess the risk of death. Results A total of 4,711 patients with confirmed SARS-CoV-2 infection were admitted to one medical system in New York City during a 6-week period. Of these, 581 (12%) had neurologic issues of sufficient concern to warrant neuroimaging. These patients were compared to 1,743 non-neurologic patients with COVID-19 matched for age and disease severity admitted during the same period. Patients with altered mentation (n = 258, p = 0.04, odds ratio [OR] 1.39, confidence interval [CI] 1.04–1.86) or radiologically confirmed stroke (n = 55, p = 0.001, OR 3.1, CI 1.65–5.92) had a higher risk of mortality than age- and severity-matched controls. Conclusions The incidence of altered mentation or stroke on admission predicts a modest but significantly higher risk of in-hospital mortality independent of disease severity. While other biomarker factors also predict mortality, measures to identify and treat such patients may be important in reducing overall mortality of COVID-19.
Elastic Electron Scattering from Methane Molecule in the Energy Range from 50–300 eV

Electron interaction with methane molecule and accurate determination of its elastic cross-section is a demanding task for both experimental and theoretical standpoints and relevant for our better understanding of the processes in Earth’s and Solar outer planet atmospheres, the greenhouse effect or in plasma physics applications like vapor deposition, complex plasma-wall interactions and edge plasma regions of Tokamak. Methane can serve as a test molecule for advancing novel electron-molecule collision theories. We present a combined experimental and theoretical study of the elastic electron differential cross-section from methane molecule, as well as integral and momentum transfer cross-sections in the intermediate energy range (50–300 eV). The experimental setup, based on a crossed beam technique, comprising of an electron gun, a single capillary gas needle and detection system with a channeltron is used in the measurements. The absolute values for cross-sections are obtained by relative-flow method, using argon as a reference. Theoretical results are acquired using two approximations: simple sum of individual atomic cross-sections and the other with molecular effect taken into the account.
Systematic detection of brain protein-coding genes under positive selection during primate evolution and their roles in cognition

The human brain differs from that of other primates, but the genetic basis of these differences remains unclear. We investigated the evolutionary pressures acting on almost all human protein-coding genes (N=11,667; 1:1 orthologs in primates) based on their divergence from those of early hominins, such as Neanderthals, and non-human primates. We confirm that genes encoding brain-related proteins are among the most strongly conserved protein-coding genes in the human genome. Combining our evolutionary pressure metrics for the protein-coding genome with recent datasets, we found that this conservation applied to genes functionally associated with the synapse and expressed in brain structures such as the prefrontal cortex and the cerebellum. Conversely, several genes presenting signatures commonly associated with positive selection appear as causing brain diseases or conditions, such as micro/macrocephaly, Joubert syndrome, dyslexia, and autism. Among those, a number of DNA damage response genes associated with microcephaly in humans such as BRCA1, NHEJ1, TOP3A, and RNF168 show strong signs of positive selection and might have played a role in human brain size expansion during primate evolution. We also showed that cerebellum granule neurons express a set of genes also presenting signatures of positive selection and that may have contributed to the emergence of fine motor skills and social cognition in humans. This resource is available online and can be used to estimate evolutionary constraints acting on a set of genes and to explore their relative contributions to human traits.
Bubble Properties and pressure Fluctuations of a Single Bubble in Water

The shape and rising velocity, pressure variation of a bubble and pressure spectrum from the pressure variation due to the rise of a bubble in water have been studied for bubble volumes from 1 × 10–6 to 5 × 10–5 m3.The vertical bubble length and radius of curvature are found to be 0.393 and 1.21 times the equivalent bubble diameter, respectively.The mean frequency of the pressure spectrum decreases with increase in bubble size. The dynamic minimum pressure is related to the radius of curvature and the maximum pressure to the vertical bubble length. The pressure spectrum is correlated with the bubble properties.The energy dissipation rate was determined from the pressure spectrum and was found to increase with increase in the bubble radius of curvature.