Miracle-dz/UniFAR-FTUs huggingface dataset:
TCRM_A_282294 1175..1183

1Escuela Internacional de Doctorado, Universidad de Sevilla, Sevilla, Spain; 2Nursing Department, Escuela Internacional de Doctorado, University of Seville, Sevilla, Spain; 3Department of Nursing, Escuela Internacional de Doctorado, University of Seville, Sevilla, Spain; 4H&RC ESTeSL-IPL, Lisbon, Portugal Purpose: To adapt and validate the Global Trigger Tool (IHI-GTT), which identifies and analyzes adverse events (AE) in hospitalized patients and their measurement properties in the Portuguese context. Methods: A retrospective cross-sectional study was based on a random sample of 90 medical records. The stages of translation and cross-cultural adaptation of the IHI-GTT were based on the Cross-Cultural Adaptation Protocol that originated from the Portuguese version, GTT-PT, for the hospital context in medical-surgical departments. Internal consistency, reliability, reproducibility, diagnostic tests, and discriminatory predictive value were investigated. Results: The final phase of the GTT-PT showed insignificant inconsistencies. The pre-test phase confirmed translation accuracy, easy administration, effectiveness in identifying AEs, and relevance of integrating it into hospital risk management. It had a sensitivity of 97.8% and specificity of 74.8%, with a cutoff point of 0.5, an accuracy of 83%, and a positive predictive value of 69.8% and a negative predictive value of 0.98%. Conclusion: The GTT-PT is a reliable, accurate, and valid tool to identify AE, with robust measurement properties.
A genetically sensitive cohort study

Objective: Victimized adolescents have elevated risk of self-injurious thoughts and behaviors. However, poor understanding of causal and non-causal mechanisms underlying this observed risk limits the development of interventions to prevent premature death among adolescents. We tested whether pre-existing family-wide and individual vulnerabilities account for victimized adolescents’ elevated risk of self-injurious thoughts and behaviors. Method: Participants were 2,232 British children followed from birth to age 18 as part of the Environmental Risk (E-Risk) Longitudinal Twin Study. Adolescent victimization (maltreatment, neglect, sexual victimization, family violence, peer/sibling victimization, cyber-victimization, and crime victimization) was assessed through interviews with participants and co-informant questionnaires at the age 18 assessment. Suicidal ideation, self-harm, and suicide attempt in adolescence were assessed through interviews with participants at age 18. Results: Victimized adolescents had an increased risk of suicidal ideation (Odds Ratio [OR]= 2.40, 95% CI=2.11-2.74), self-harm (OR=2.38, 95% CI=2.10-2.69), and suicide attempt (OR=3.14, 95% CI=2.54-3.88). Co-twin control and propensity-score matching analyses showed that these associations were largely accounted for pre-existing familial and individual vulnerabilities, respectively. Over and above their prior vulnerabilities, victimized adolescents still showed a modest elevation in risk for suicidal ideation (OR=1.36, 95%CI=1.06-1.76) and self-harm (OR=1.50, 95% CI=1.18-1.91), but not suicide attempt (OR=1.28, 95% CI=0.83-1.98). Conclusions: Risk for self-injurious thoughts and behaviors in victimized adolescents is only partly explained by the experience of victimization. Pre-existing vulnerabilities account for a large proportion of the risk. Therefore, effective
Policy implementation as practice? Using social practice theory to analyse a UK SME transport-related behaviour change initiative

Following the ‘practice turn’ in energy research, increasing attention is being paid to the practices of policy making. However, energy policy implementation remains under-researched. Using auto-ethnographic and extensive interview data, this paper provides a narrative account of ‘Sustainable Routes’: a project offering grants and advice to small business in the UK to reduce their transport-related emissions. The project exemplifies the model of Multi-Level Governance (MLG), implemented by a coalition of actors, across multiple scales. Research data is analysed using practice theory. Building on recent debates over researching large-scale phenomena, the notion of connected situationalism is used to analyse policy implementation as a bundle of practices. ‘Zooming in’ on periods of disruption following project audits, findings trace how tension and conflict arose in the relationships between actors, played out through the changing constellation of meanings, materials and competences. They highlight for example, how the reinterpretation of policy documentation led material elements such as bicycles to become associated with meanings of risk and liability, requiring a new set of competences on behalf of the carriers of practice. This empirical account demonstrates the value of practice theory for analysing multi-actor, multi-scalar research data, and indicates potential for future research on policy implementation.
PLACTIC MONOID, CRYSTALS,

We study cells in generalised Bott-Samelson varieties for type C n . These cells are parametrised by certain galleries in the aﬃne building. We deﬁne a set of readable galleries we show that the closure in the aﬃne Grassmannian associated to a gallery in this set is an MV cycle. This then deﬁnes a map from the set of readable galeries to the set of MV cycles, which we show to be a morphism of crystals. We further compute the ﬁbres of this map in terms of the Littelmann path model.
Analog of gravitational force in hyperbolic metamaterials

Sub-wavelength confinement of light in nonlinear hyperbolic metamaterials due to formation of spatial solitons has attracted much recent attention because of its seemingly counter-intuitive behavior. In order to achieve self-focusing in a hyperbolic wire medium, a nonlinear self-defocusing Kerr medium must be used as a dielectric host. Here we demonstrate that this behavior finds natural explanation in terms of analogue gravity. Wave equation describing propagation of extraordinary light inside hyperbolic metamaterials exhibits 2+1 dimensional Lorentz symmetry. The role of time in the corresponding effective 3D Minkowski spacetime is played by the spatial coordinate aligned with the optical axis of the metamaterial. Nonlinear optical Kerr effect bends this spacetime resulting in effective gravitational force between extraordinary photons. In order for the effective gravitational constant to be positive, negative self-defocusing Kerr medium must be used as a host. If gravitational self-interaction is strong enough, spatial soliton may collapse into a black hole analogue.
Computing with functions in two dimensions

New numerical methods are proposed for computing with smooth scalar and vector valued functions of two variables defined on rectangular domains. Functions are approximated to essentially machine precision by an iterative variant of Gaussian elimination that constructs near-optimal low rank approximations. Operations such as integration, differentiation, and function evaluation are particularly efficient. Explicit convergence rates are shown for the singular values of differentiable and separately analytic functions, and examples are given to demonstrate some paradoxical features of low rank approximation theory. Analogues of QR, LU, and Cholesky factorizations are introduced for matrices that are continuous in one or both directions, deriving a continuous linear algebra. New notions of triangular structures are proposed and the convergence of the infinite series associated with these factorizations is proved under certain smoothness assumptions. A robust numerical bivariate rootfinder is developed for computing the common zeros of two smooth functions via a resultant method. Using several specialized techniques the algorithm can accurately find the simple common zeros of two functions with polynomial approximants of high degree (≥ 1,000). Lastly, low rank ideas are extended to linear partial differential equations (PDEs) with variable coefficients defined on rectangles. When these ideas are used in conjunction with a new one-dimensional spectral method the resulting solver is spectrally accurate and efficient, requiring O(n) operations for rank 1 partial differential operators, O(n) for rank 2, and O(n) for rank ≥ 3 to compute an n × n matrix of bivariate Chebyshev expansion coefficients for the PDE solution. The algorithms in this thesis are realized in a software package called Chebfun2, which is an integrated two-dimensional component of Chebfun.
Kindlins as modulators of breast cancer progression

Kindlin-1 (K1, FERMT1), Kindlin-2 (K2, FERMT2), and Kindlin-3 (K3, FERMT3) are the three members of the kindlin family of adapter proteins found in mammals. One or more kindlins are found in most cell types, K1 primarily in epithelial cells, K3 in primarily hematopoietic cells and also endothelial cells, and K2 is very broadly distributed. The kindlins consist primarily of a 4.1-erzin-radixin-moiesin (FERM) domain, which is transected by a lipid-binding plextrin-homology (PH) domain. Deficiencies of each kindlin in mice and/ or humans have profound pathogenic consequences. The most well-established function of kindlins depends on their ability to participate in the activat integrin adhesion receptors. This function depends on the binding of each kindlin to the beta subunit of integrins where it cooperates with talin to enhance avidity of interactions with cognate extracellular matrix ligands. Deficiencies of many different integrins are lethal, are critical for normal development of mammary tissue, and excessive expression and/or activation of certain integrins are associated with progression and metastasis of breast cancer. However, via its interaction with many other intracellular proteins, kindlins can influence numerous cellular responses. Changes in expression of each of the three kindlins have been reported in association with breast cancer, with several studies indicating that kindlins are among the most upregulated genes in breast cancer. The association of abnormal functions of K2 with breast cancer is particularly extensive with many reports indicating that it is a major driver of breast cancer via its promotion of cancer cell proliferation, survival, adhesion, migration, invasion, the epithelial-to-mesenchymal transition and its influence on macrophage recruitment and phenotype. These associations suggest that the kindlins and their functions represent an intriguing therapeutic target for exploration of breast cancer therapy.
Social connectedness, mindfulness, and coping as protective factors during the COVID‐19 pandemic

Abstract The COVID‐19 pandemic has had an unprecedented psychological impact, revealing immense emotional disturbances among the general population. This study examined the extent to which social connectedness, dispositional mindfulness, and coping moderate symptoms of anxiety and depression in 1242 adults under the same government‐issued COVID‐19 stay‐at‐home mandate. Participants completed measures of anxiety, depression, dispositional mindfulness, social connectedness, and coping, and regression analyses were used to examine associations and interaction effects. Results indicated that social connectedness and dispositional mindfulness were associated with reduced symptoms. For individuals living with a partner, decreased mindfulness and avoidant coping were associated with anxious symptoms. In households with children, overutilization of approach coping served to increase symptoms of depression. Results indicate the importance of considering social connectedness, mindfulness, and coping in counseling to enhance factors serving to protect clients during a public health crisis. Implications for professional counselors and areas of future research are discussed.
Neuropathy in Parkinson's Disease: Risk Determinants and Impact on Quality of Life

Neuropathy has been described in significantly higher proportion of PD patients than in control subjects. This study ascertains the prevelance of neuropathy and its determinants in PD patients, in particular relation with nutritional status, along with impact of neuropathy on Quality of life. Methods: This was a hospital based observational cross-sectional study of PD patients attending the Neurology OPD of a tertiary care hospital. The prevalence and type of neuropathy was determined using the validated MNSI scale. The nutritional status was assessed using MNA score and PDQ-39 was used for assessing quality of life. Patients with and without neuropathy were compared to ascertain risk factors for neuropathy. Results: Twenty-four out of 93 PD patients (26%) had neuropathy and 12 (50%) out of them had painful neuropathy. Older patents and those who had longer duration of disease had higher prevalence of neuropathy. In addition there was significant correlation with malnutrition and neuropathy. 79% of patients with neuropathy had abnormal nutritional status. On comparison of patients with painful neuropathy as compared to those without pain, Vitamin B 12 levels were found to be low only in the former group. Conclusions: Our study shows that there is significant prevalence of neuropathy in PD patents that affects the quality of life of PD patients. Neuropathy in PD is disease dependent and is precipitated by malnutrition. Hence, neuropathy must be timely diagnosed and effective nutritional management may help to improve the patient's quality of life.
DPP-4 inhibition mediated antidiabetic potential of phytoconstituents of an aqueous fruit extract of Withania coagulans (Stocks) Dunal: in-silico, in-vitro and in-vivo assessments

Abstract The DPP-4 inhibition is an interesting target for the development of antidiabetic agents which promotes the longevity of GPL-1(Glucagon-like peptide 1). The current study was intended to assess DPP-4(Dipeptidyl Peptidase-4) inhibition mediated antidiabetic effect of phytocompounds of an aqueous fruit extract of Withania coagulans (Stocks) Dunal by in-vitro, in-silico and in-vivo approaches. The phytoconstituents screening was executed by LCMS (Liquid Chromatography with tandem mass spectrometry). The in-vitro and in-vivo, DPP-4 assays were performed by using available kits. The in-vitro DPP-4 activity was inhibited up to 68.3% by the test extract. Accordingly, in-silico determinations of molecular docking, molecular dynamics and pharmacokinetics were performed between the target enzyme DPP-4 and leading phytocompounds. The molecular dynamics authenticated the molecular docking data by crucial parameters of cytosolic milieu by the potential energy, RSMD (Root Mean Square Deviation), RSMF (Root Mean Square Fluctuation), system density, NVT (Number of particles at fixed volume, ensemble) and NPT (Number of particles at fixed pressure, ensemble). Accordingly, ADMET predictions assessed the druggability profile. Subsequently, the course of the test extract and the sitagliptin (positive control), instigated significant (p ≤ 0.001) ameliorations in HOMA indices and the equal of antioxidants in nicotinamide-streptozotocin induced type 2 diabetic animal model. Compassionately, the histopathology represented increased pancreatic cellular mass which caused in restoration of histoarchitectures. It has been concluded that phytoconstituents in W. coagulans aqueous fruit extract can regulate DPP-4, resulting in improved glucose homeostasis and enhanced endocrinal pancreatic cellular mass. Communicated by Ramaswamy H. Sarma
The impact of crop specialization on nutritional intake: Evidence from farm households in China

Background In the wake of the severe impact of COVID-19 on the food security of the vulnerable groups in rural areas, the issue of how to achieve the Sustainable Development Goals 2 aims to “Zero Hunger” (SDG 2) and ensure the food safety of farmers has drawn unprecedented attention. Nutritional intake is generally used as an important indicator to reflect family food security. Under the background that Chinese farmers have gradually changed from the traditional diversified production mode to the specialized production of crops, the main purpose of this article is to explore what are the impact of crop specialization on farmers’ nutritional intake? Could the specialization of crop production be taken as an important measure to ensure the food safety of farmers and achieve the SDG 2? Methods Based on the micro-survey data from 866 farmer households in China, this paper using Seemingly Unrelated Regressions model, Group Regression model and Mediating Effect model to analyze the average and heterogeneous effects of crop specialization on the nutritional intake of farmers, as well as the mediating effect of income. In addition, robustness test and endogenous treatment were performed by using alternative explanatory variables and IV-2SLS method was used to estimate the results. Results After correcting for endogenous bias, crop specialization had a significant negative impact on energy intake and fat intake of farmers at the statistical level of 5% and 1% respectively, especially for farmers in mountainous areas. Household income played a mediating effect on the effect of crop specialization on farmers’ energy and fat intake, and the proportion of the masking effect was 8.43% and 8.96% respectively. In addition, household financial capital and social capital have a significant positive impact on farmers’ nutritional intake. Conclusions Crop specialization cannot guarantee the food safety of farmers in terms of nutritional intake. However, when the development trend of crop specialization is irreversible, more attention should be paid to improving the level of various livelihood capital of farmers, especially those in mountainous areas, and to continuously increasing their income to ease and ultimately eliminate the negative impact of crop specialization on farmers’ nutritional intake, which finally make everyone realize the SDG 2.
Modeling and anti-sway control of ship-mounted crane

This article analyzes the dynamics of a ship-mounted crane and establishes the mathematical model of the load. Based on the mathematical model, the time-delayed feedback control algorithm is proposed to anti-load sway. The Lambert W function and Newton–Raphson method are used to prove the stability of control system. The contour plot of the system damping is obtained; by selecting appropriate time delay and system gain, the system damping increases and load sway rapidly decays, thereby the system is stable. The co-simulation and experimental results show that the delayed feedback controller has better performance in anti-sway and robustness.
Purification, Partial Characterization, and Evaluation of the Antiulcer Activity of Calotropis procera Leaf Lectin

Background: Lectins are proteins with therapeutic and diagnostic potential that can be applied in battling various ailments. Aim and Objective: This study was designed to purify and characterize the hemagglutinating activity derived from the leaves of Calotropis procera and its possible role in protecting the stomach against ethanol-induced lesions. Methods: The Calotropis procera leaf lectin (ProLec), was isolated by homogenization of the defatted leaf powder in Phosphate-Buffered Saline (PBS) and purified by affinity chromatography on Sephadex G-100. The lectin was eluted from the affinity column by 3% acetic acid and was physicochemically characterized. In a dose-dependent manner, ProLec was administered to rats with ethanol-induced ulcers, and biochemical, histopathological, and toxicological examinations were performed. Results: ProLec is a heterodimer of 75 and 68 kDa. It agglutinated all human RBCs, whereas it showed weak interaction with animal erythrocytes. The protein was optimally active at 25 °C and was labile above this temperature. ProLec exhibited two pH optima and was a metalloprotein requiring Ca, Mn, and Ni. It contains 1.6% tryptophan residues of which about 1% is exposed and critical for lectin activity. The lectin exhibited a potent gastroprotective effect against ethanol-induced gastric lesions with no apparent toxicity to both kidneys and liver. Examination of the pH of the gastric juice of lectin-treated animals indicated a possible role of lectin in maintaining stomach acidity within the normal ranges compared to the gastric juice pH of animals that received ethanol only. Conclusion: These results may suggest that ProLec could conceivably be a good future drug for the treatment of gastric ulcers, however, extensive immunological and toxicological research remains to be done.
Closed-loop Control of Ankle Plantarflexors and Dorsiflexors using an Inverted Pendulum Apparatus

In the past, it has been shown that functional electrical stimulation (FES), when applied to lower limbs, can facilitate quiet stance in patients with various neurological disorders. Furthermore, the literature suggests that able-bodied individuals regulate balance during quiet stance using a control strategy that is similar to proportional-integral-derivative (PID) control. The purpose of this study was to test if a PID control strategy is capable of effectively regulating an FES system at the ankle joints during quiet stance. Specifically, we tested whether able-bodied individuals with compromised visual, vestibular and proprioceptive senses, would exhibit improved ankle joint control if FES was applied to contract the ankle muscles using a closed-loop, PID control strategy. In what follows we show that the proposed PID control strategy was able to outperform voluntary control of the ankle joint, indicating that the controller could be considered for use in neurological patients, including spinal cord injured individuals.
Increased Phospho‐AKT in Blood Cells from LRRK2 G2019S Mutation Carriers

The purpose of this study was to investigate whether differential phosphorylation states of blood markers can identify patients with LRRK2 Parkinson's disease (PD). We assessed phospho(P)‐Ser‐935‐LRRK2 and P‐Ser‐473‐AKT levels in peripheral blood cells from patients with G2019S LRRK2‐associated PD (L2PD, n = 31), G2019S LRRK2 non‐manifesting carriers (L2NMC, n = 26), idiopathic PD (iPD, n = 25), and controls (n = 40, total n = 122). We found no differences at P‐Ser‐935‐LRRK2 between groups but detected a specific increase of P‐Ser‐473‐AKT levels in all G2019S carriers, either L2PD or L2NMC, absent in iPD. Although insensitive to LRRK2 inhibition, our study identifies P‐Ser‐473‐AKT as an endogenous candidate biomarker for peripheral inflammation in G2019S carriers using accessible blood cells. ANN NEUROL 2022;92:888–894
A 3D Lattice Boltzmann Code for Modeling Flow and Multi-Component Dispersion

This report documents the JB_PH lattice Boltzmann code, a program for modeling multi-component flow and dispersion. The lattice Boltzmann method is reviewed and methods are compared for increasing the efficiency of the algorithms. Accuracy of the code is tested with four benchmark problems: (1) permeability of a simple cubic array of spheres; (2) Taylor-Aris dispersion between infinite plates; (3) dispersion in a duct; and (4) dispersion in a simple cubic array of spheres. The memory and speed requirements of the method are assessed in the context of the benchmarks. The code structure and purpose of each major function are described, and instructions are given for compilation.