Miracle-dz/UniFAR-FTUs huggingface dataset:
Psychological trauma and emotional upheaval as revealed in academic writing: The case of COVID-19

ABSTRACT The current paper used a preregistered set of language dimensions to indicate how scientists psychologically managed the COVID-19 pandemic and its effects. Study 1 evaluated over 1.8 million preprints from arXiv.org and assessed how papers written during the COVID-19 pandemic reflected patterns of psychological trauma and emotional upheaval compared to those written before the pandemic. The data suggest papers written during the pandemic contained more affect and more cognitive processing terms to indicate writers working through a crisis than papers written before the pandemic. Study 2 (N = 74,744 published PLoS One papers) observed consistent emotion results, though cognitive processing patterns were inconsistent. Papers written specifically about COVID-19 contained more emotion than those not written about COVID-19. Finally, Study 3 (N = 361,189 published papers) replicated the Study 2 emotion results across more diverse journals and observed papers written during the pandemic contained a greater rate of cognitive processing terms, but a lower rate of analytic thinking, than papers written before the pandemic. These data suggest emotional upheavals are associated with psychological correlates reflected in the language of scientists at scale. Implications for psychology of language research and trauma are discussed.
New therapies for nontuberculous mycobacterial lung infection

Purpose of review Although nontuberculous mycobacterial pulmonary disease is increasing in incidence, outcomes remain less than optimal highlighting the unmet need for developing novel therapies. Recent findings Several new antibiotic formulations, novel antibiotics, and novel nonantibiotic treatments have recently demonstrated positive results in treating nontuberculous mycobacterial pulmonary disease. Summary Promising novel therapies are currently under investigation fueling much needed interest and enthusiasm in the nontuberculous mycobacterial pulmonary disease space and will hopefully lead to improved understanding and outcomes in this complex disease.
Economic Evaluation of Universal Varicella Vaccination in Mexico

Background: Universal varicella vaccination has proven to be cost-effective (CE) in countries where implemented. However, this has not been evaluated for Mexico. Methods: The yearly disease burden (varicella cases/deaths, outpatient visits, and hospitalizations) was derived from Mexican seroprevalence data adjusted to the 2020 population. The yearly economic burden was calculated by combining disease with Mexican unit cost data from both health care and societal perspectives. Four different vaccination strategies were evaluated: (1) 1 dose of varicella vaccine at 1 year old; (2) 2 doses at 1 and 6 years; (3) 1 dose of varicella vaccine at 1 year, and quadrivalent measles-mumps-rubella-varicella vaccine at 6 years; (4) 2 doses of measles-mumps-rubella-varicella vaccine at 1 and 6 years. We developed an economic model for each vaccination strategy where 20 consecutive birth cohorts were simulated. Vaccination impact (number of avoided cases/deaths) was evaluated for a 20-year follow-up period based on vaccine effectiveness (87% and 97.4% for 1 and 2 doses), and assuming a 95% coverage. We estimated annual costs saved, incremental cost-effectiveness ratio, and costs per life year gained. Results: Avoided cases during the 20-year follow-up with 1, and 2 doses were 20,570,722 and 23,029,751, respectively. Strategies 1 and 2 were found to be cost saving, and strategy 3 to be CE. Strategy 4 was not CE. Strategies 1 and 2 would allow saving annually $53.16 and $34.41 million USD, respectively, to the Mexican society. Conclusions: Universal varicella vaccination, using 1 dose or 2 doses, would result in a cost-beneficial and CE public health intervention in Mexico.
Azithromycin and Septic Shock Outcomes

Introduction: Although there is evidence describing the immunomodulatory effects of macrolide antibiotics, there is little literature exploring the clinical effects these properties may have and their impact on measurable outcomes. Objective: The purpose of this study was to determine if empiric antimicrobial regimens containing azithromycin shorten time to shock resolution. Methods: A retrospective study was performed in adults with septic shock admitted to intensive care units (ICUs) of 3 university-affiliated, urban teaching hospitals between June 2012 and June 2016. Eligible patients with septic shock required treatment with norepinephrine as the first-line vasopressor for a minimum of 4 hours and received at least 48 hours of antimicrobial treatment from the time of shock onset. Propensity scores were utilized to match patients who received azithromycin to those who did not. Results: A total of 3116 patients met initial inclusion criteria. After propensity score matching, 258 patients were included, with 124 and 134 patients in the azithromycin and control groups, respectively. Median shock duration was similar in patients treated with or without azithromycin (45.6 hr vs 59.7 hr, P = .44). In-hospital mortality was also similar (37.9% vs 38.1%, P = .979). There were no significant differences in mechanical ventilation duration, ICU length of stay (LOS), or hospital LOS. Conclusions: In patients admitted to the ICU with septic shock, empiric azithromycin did not have a significant effect on shock duration, mechanical ventilation duration, ICU LOS, hospital LOS, or in-hospital mortality.
Predictive value of oxidative stress biomarkers in drug-free patients with bipolar disorder

Abstract Objective Oxidative stress is one of the primary etiological mechanisms of bipolar disorder (BD). Methods The present study was conducted over a period of 24 months on Tunisian on 34 drug‑free male patients with BD (mean age: 34.5 years) and 101 age and gender matched controls (mean age: 34.20 years) were enrolled in the study. Results Plasma reduced glutathione (GSH) and total thiols levels were significantly decreased in patients compared to controls (respectively p < .001; p = .009). In addition, malondialdehyde (MDA), advanced oxidation protein products (AOPP), protein carbonyls (PC) and homocysteine (Hcys) concentrations and glutathione peroxidase (GSH-Px) activity were significantly increased in patients compared to controls (p = .002; p < .001; p = .001; p < .001 and p = .016, respectively). The binary logistic regression analysis revealed that MDA, AOPP and Hcys could be considered as independent risk factors for BD. When using CombiROC analysis, a remarkable increase in the area under the curve (AUC) with higher sensitivity (Se) and specificity (Sp) for MDA, AOPP, PC, GSH-Px and Hcys combined markers was observed. Conclusions Overall, the identification of the predictive value of these five selected biomarkers related to oxidative stress in drug free patients should lead to a better identification of the etiological mechanism of BD.
Dielectric Properties of Glucose Solutions in the 0.5–67 GHz Range

The dielectric properties of glucose solved in pure water as well as in a physiological solution have been measured. The results are considered in the context of noninvasive diabetes control. At least 0.002 percent measurement accuracy is required to achieve the same accuracy as obtained with traditional finger pricking. © 2013 Wiley Periodicals, Inc. Microwave Opt Technol Lett 55:1916–1917, 2013
Hyperglycemia and blood glucose deterioration are risk factors for severe COVID‐19 with diabetes: A two‐center cohort study

We aimed to assess whether blood glucose control can be used as predictors for the severity of 2019 coronavirus disease (COVID‐19) and to improve the management of diabetic patients with COVID‐19. A two‐center cohort with a total of 241 confirmed cases of COVID‐19 with definite outcomes was studied. After the diagnosis of COVID‐19, the clinical data and laboratory results were collected, the fasting blood glucose levels were followed up at initial, middle stage of admission and discharge, the severity of the COVID‐19 was assessed at any time from admission to discharge. Hyperglycemia patients with COVID‐19 were divided into three groups: good blood glucose control, fair blood glucose control, and blood glucose deterioration. The relationship of blood glucose levels, blood glucose control status, and severe COVID‐19 were analyzed by univariate and multivariable regression analysis. In our cohort, 21.16% were severe cases and 78.84% were nonsevere cases. Admission hyperglycemia (adjusted odds ratio [aOR], 1.938; 95% confidence interval [95% CI], 1.387–2.707), mid‐term hyperglycemia (aOR, 1.758; 95% CI, 1.325–2.332), and blood glucose deterioration (aOR, 22.783; 95% CI, 2.661–195.071) were identified as the risk factors of severe COVID‐19. Receiver operating characteristic (ROC) curve analysis, reaching an area under ROC curve of 0.806, and a sensitivity and specificity of 80.40% and 68.40%, respectively, revealed that hyperglycemia on admission and blood glucose deterioration of diabetic patients are potential predictive factors for severe COVID‐19. Our results indicated that admission hyperglycemia and blood glucose deterioration were positively correlated with the risk factor for severe COVID‐19, and deterioration of blood glucose may be more likely to the occurrence of severe illness in COVID‐19.
Real life use of dolutegravir doravirine dual regimen in experienced elderly PLWH with multiple comorbidities and on polypharmacy

Abstract By increasing life expectancy of people living with HIV, the most clinical challenge is managing both drug-to-drug interactions and comorbidities (especially metabolic). Doravirine (DOR), a new non-nucleoside reverse transcriptase inhibitor, recently approved for the treatment of HIV, could be a good companion of dolutegravir (DTG) in a dual regimen for experienced elderly patients with multimorbidity and polypharmacy. We herein report our preliminary experience in a small cohort of elderly patients (>50 years of age) with multimorbidity and on polypharmacy who were switched to DOR/DTG dual regimen and followed-up for 3 months. The study was conducted at the Infectious and Tropical Diseases Unit of Padua University Hospital, Italy. Eighteen patients were included, 72.2% males and 27.8% postmenopausal women, mean age was of 61.3 years (7.6), 50% experienced AIDS events. Switches to DOR and DTG were mainly due to high cardiovascular and metabolic risk (72.2%), and interactions among comedications (50%). Antiretrovirals that subjects were switched off were mostly boosted protease inhibitors 66.7%. We observed a viral suppression among all subjects. Interestingly, we observed a statistically significant reduction in body mass index, body weight and waist circumference, eGFR, and a significant increase in serum creatinine levels. No significant changes in CD4+ T cell count was observed from the baseline. Lipid and fasting glucose values did not change significantly. To the best of our knowledge this is the first experience reporting real-life outcome of switch to DTG + DOR in elderly with multimorbidity and on polypharmacy. From our very preliminary data the dual combination of DTG and DOR could be a good treatment strategy for these subjects. However, our findings need to be validated on a greater number of patients.
Can Emerging Adults’ Dating Psychological Aggression be Explained by Family-of-Origin Psychological Aggression, Emotion Dysregulation, and Drinking?

Intimate partner violence (IPV) impacts the lives of millions of individuals; nearly 1 in 4 women and 1 in 7 men report experiencing IPV during their lifetime. Previous studies frequently cite family-of-origin aggression as a risk factor for later experiences with IPV. Research with adults who engage in IPV finds an association with childhood exposure to family violence, but the strength of that association may vary. Psychological aggression often pre-dates more severe IPV and college students are a particular risk group for IPV. Additionally, previous literature has revealed gender differences in response to childhood experiences of family violence. As such, the current study sought to identify factors that explain and moderate risk for dating psychological aggression (DPA) in college adults, and sex differences in those associations. Participants (464 women, 142 men), who were in a current romantic relationship lasting at least 3 months, completed measures of past psychological aggression in the family-of-origin (PAF), current emotion dysregulation, risky drinking, and DPA perpetrated in current dating relationships. Emotion dysregulation mediated the relationship between PAF and current DPA; however, differences among specific types of PAF and sex were noted. Results support an intergenerational transmission of PAF and suggest that parent–child sex dyads influence this process. The findings also provide evidence that higher levels of drinking are associated with increased emotion dysregulation. These results contrast with the alcohol expectancy for stress relief and support public messaging that alcohol use does not relieve stress. Clinical and research implications for prevention of the intergenerational transmission of aggression are discussed.
Sex Differences across Retrospective Transitions in Posttraumatic Stress and Substance Use Disorders

Abstract Objectives: Concurrent substance use disorder (SUD) and posttraumatic stress disorder (PTSD) occur at high rates and are typically associated with poor treatment outcomes in both sexes. However, women have a propensity to cope with increased negative affect via substance use in comparison to men; thus, it is important to elucidate the sex-specific bidirectional relationships between SUD and PTSD to improve our understanding of concurrent SUD/PTSD in men and women. Methods: Using data from the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC-Wave 3; n = 36,309), the present study evaluated the impact of sex on the relationship between past-year SUDs (new, remitted, ongoing), including alcohol and drug use, and retrospective transitions in new vs. absent and ongoing vs. remitted diagnoses of PTSD. Additionally, the impact of sex was explored in models examining past year PTSD (new, remitted, ongoing) and retrospective transitions in new vs. absent and ongoing vs. remitted diagnosis of SUDs. Diagnostic transitions were based on retrospective reporting. Results: Results indicated that new, remitted, and ongoing SUDs increase the likelihood of new PTSD diagnoses (OR range = 2.53–8.11; p < 0.05). Among individuals with ongoing drug use disorders (DUD), there were greater odds of ongoing PTSD (OR = 2.10, p < 0.01). When examining the relationship reciprocally, new, remitted, and ongoing PTSD increased the likelihood of new SUDs (OR range = 2.50–8.22; p < 0.05), and ongoing PTSD increased the likelihood of ongoing SUD and DUD (OR = 1.40, 1.70, respectively; p < 0.05). Sex-specific analyses revealed that the relationship between PTSD and SUDs varies between sexes, particularly among women. For instance, women with new PTSD had higher odds of SUDs, and women with ongoing PTSD were almost 2.5 times more likely to have an ongoing DUD. Women with a new PTSD diagnosis were more likely to be diagnosed with a new SUD (OR = 3.27) and an ongoing DUD (OR = 3.08). Conclusions: Results indicate a bidirectional relationship between PTSD and SUD that is in many instances larger in women. Thus, illustrating potential sex-specific differences in underlying mechanisms implicated in SUD/PTSD, warranting additional research.
Transient analysis of a crossbonded cable system underneath a bridge

Transients on a crossbonded cable installed underneath a bridge and connected with overhead lines are analyzed using the EMTP (ElectroMagnetic Transients Program). Calculated results of the sheath voltages on a system composed of only a cable show that the maximum overvoltages on the cable installed underneath the bridge, which is a kind of overhead cable, are higher by about 2.5 times than those on an ordinary underground cable. The iron framework of the bridge, which is simulated as parallel overhead conductors to the cable, reduces the overvoltages by about 20% to 50% due to mutual coupling. When overhead lines are connected to the cable system at both terminals, the sheath overvoltages are reduced to about 20% of those in the case of the cable system alone, but the reduction by the iron frameworks of the overvoltages becomes less pronounced. It is emphasized that special attention should be paid to the insulation coordination of a crossbonded cable installed to a bridge. >
The profile of musculoskeletal pain and its associations with sleep quality and depression during the COVID-19 in Turkey

Background The current pandemic has affected people’s health multidimensionally. This study aims to investigate musculoskeletal pain, sleep quality, depression levels, and their relationships in individuals belonging to different age groups during COVID-19 in Turkey. Methods A web-based self-administered survey that consisted of demographic questions, The Beck Depression Inventory (BDI), Pittsburgh Sleep Quality Index (PSQI), and scores of musculoskeletal pain was sent to participants. Pearson correlation analysis was used for determining the statistical relationship between variables. Results The study includes 1,778 participants. The highest percentage for mild, moderate, and severe pain was in the head (49.8%), back (15.5%), and head (11.5%), respectively. The PSQI-total had shown a weak correlation with pain levels in all body parts. The highest correlation for sleep quality and pain levels was between the PSQI-5 and lower back pain. There was a weak correlation between PSQI-2 and the BDI score, and a moderate correlation between the PSQI-1, PSQI-5, PSQI-7, PSQI-total, and BDI score. Pain in all body parts showed a weak correlation with depression level. Conclusions This study showed that musculoskeletal pain was varied in body parts with different intensities according to age groups in Turkey during the pandemic. The most common pain was in the head, back, and lower back. Headache was found correlated with the parameters of sleep quality. Pain of the head, neck, back, lower back, and shoulder were correlated with sleep latency. Sleep quality was associated with depression and musculoskeletal pain, while musculoskeletal pain was correlated with depression.
RC Columns Strengthened with Steel Angles and Battens: Experimental Results and Design Procedure

AbstractIn this paper, an analytical model for the design of axially loaded strengthened RC columns with steel angles and battens is presented. Cases of directly loaded and not directly loaded steel angles are considered. The model considers the contribution in confinement pressures caused by transverse battens and steel angles and the contribution in terms of the load-carrying capacity of steel angles subjected to axial force and the bending moment. An experimental investigation on the compressive behavior of eight short, confined, RC columns externally strengthened with steel angles and steel battens with various pitches was carried out, and has been utilized as support for the analytical model. The analytical results generated are compared with the experimental data available in the literature and with those obtained by using existing analytical models. The comparison shows the acceptable prediction of the experimental results in both cases of directly loaded and not directly loaded steel angles. Final.
Seed priming with phosphorus increased germination and yield of okra

In order to sort out the problem of uneven and poor germination in okra, a research work “the effect of seed priming on okra cv. Sabaz Pari with different sources of phosphorus and soaking durations” was carried out at Horticulture Research Farm, Khyber Pakhtoonkhwa Agricultural University Peshawar, Pakistan, during summer 2008. The experiment was laid down in randomized complete block design with split plot arrangements. There were four priming sources (distilled water, 1% phosphorus (P) solution of each of diammonium phosphate (DAP), single super phosphate (SSP), SSP+ Na 2CO 3) with soaking durations from 4 h and their twofolds up to 48 h along with unprimed seed (control). Priming sources and durations significantly affected germination percentage, survival percentage, number of days to emergence and first flowering, plant height, leaves number per plant, pods number per plant, pod length, seeds number per pod and pod yield. SSP solutions with 24 h soaking duration gave the best results, followed by DAP, while unsoaked seeds proved to be the poorest. Hence, seed priming in SSP solution (1%P) for 24 h is recommended for okra.
Safety of breast/chest-feeding by those infected by SARS-CoV-2

Purpose of review One important question from the outset of the pandemic has been whether a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected person's milk might be a vehicle for SARS-CoV-2 transmission. This review summarizes the most recent data on this topic. Recent findings A SARS-CoV-2 sIgA response in milk after infection is very common. To date, there has been no evidence that SARS-CoV-2 transmits via human milk. Though viral RNA has been identified in a minority of milk samples studied, infectious virus particles have not. Summary The highly dominant transmission route for SARS-CoV-2 is via inhalation of respiratory droplets containing virus particles. Other routes of transmission are possible, including fecal–oral, trans-placental, and to a much lesser extent, via a contaminated surface. SARS-CoV-2 cannot transmit via human milk. There is no evidence that infants should be separated from SARS-CoV-2-infected mothers who are well enough to establish or continue breastfeeding.
Autism spectrum disorder and schizophrenia: An updated conceptual review

Autism spectrum disorder (ASD) and schizophrenia (SCZ) are separate disorders, with distinct clinical profiles and natural histories. ASD, typically diagnosed in childhood, is characterized by restricted or repetitive interests or behaviors and impaired social communication, and it tends to have a stable course. SCZ, typically diagnosed in adolescence or adulthood, is characterized by hallucinations and delusions, and tends to be associated with declining function. However, youth with ASD are three to six times more likely to develop SCZ than their neurotypical counterparts, and increasingly, research has shown that ASD and SCZ converge at several levels. We conducted a systematic review of studies since 2013 relevant to understanding this convergence, and present here a narrative synthesis of key findings, which we have organized into four broad categories: symptoms and behavior, perception and cognition, biomarkers, and genetic and environmental risk. We then discuss opportunities for future research into the phenomenology and neurobiology of overlap between ASD and SCZ. Understanding this overlap will allow for researchers, and eventually clinicians, to understand the factors that may make a child with ASD vulnerable to developing SCZ.