Miracle-dz/UniFAR-FTUs huggingface dataset:
A systematic review and meta-analysis

Objective: The present study aimed to conduct a systematic review and meta-analysis to evaluate the relationships between ATP2B1 gene polymorphisms with blood pressure (BP) level and susceptibility to hypertension. Methods:PubMed, Web of Science, Embase and China National Knowledge Infrastructure (CNKI) Databases were systematically searched by 2 independent researchers to screen studies on ATP2B1 gene polymorphisms and BP related phenotypes. The records retrieval period was limited from the formation of the database to March 4, 2021. Pooled odds rations (ORs) or b and their 95% confidence intervals (95%CI) were calculated to assess the association between ATP2B1 gene polymorphisms and the risk of hypertension or BP levels. Publication bias and sensitivity analysis were conducted to find potential bias. All the statistical analysis were conducted with Stata version 11.0 software. Results: A total of 15 articles were ultimately included in the present study, including 15 polymorphisms of ATP2B1 gene. Nine articles (N=65,362) reported the polymorphism rs17249754, and 7 articles(N=91,997) reported rs2681472 (both loci were reported in 1 article). Meta-analysis showed that rs17249754 (G/A) and rs2681472 (A/G) were associated with the susceptibility to hypertension (rs17249754: OR=1.19, 95%CI: 1.10–1.28; rs2681472: OR=1.15, 95%CI: 1.12–1.17), and were positively associated with systolic BP (SBP) and diastolic blood pressure (DBP) (rs17249754: SBP, b=1.01, 95%CI: 0.86–1.16, DBP, b=0.48, 95%CI: 0.30–0.66; rs2681472: SBP, b=0.92, 95%CI: 0.77–1.07, DBP, b=0.50, 95%CI: 0.42–0.58) in the additive genetic model. Subgroup analysis stratified by race, population, sample size, and BPmeasurement method revealed that the association between A allele in rs2681472 polymorphism and risk of hypertension was slightly stronger in European (EUR) populations (OR=1.16, 95%CI: 1.13–1.20) than in East Asians (OR=1.14, 95%CI: 1.10–1.17). While in East Asians, relation between rs17249754 with risk of hypertension (OR=1.19, 95%CI: 1.10–1.28) is stronger than rs2681472 (OR=1.14, 95%CI: 1.10–1.17). Conclusions: Our study demonstrated that ATP2B1 gene polymorphism rs2681472 and rs17249754 were associated with BP levels and the susceptibility to hypertension. Abbreviations: BP = blood pressure, DBP = diastolic blood pressure, EUR = European, HTN = hypertension, SBP = systolic blood pressure.
A systematic review and meta-analysis

Abstract Background: Many observational studies have reported an association between weight fluctuation and all-cause mortality. However, the conclusions obtained from these studies have been unclear. Objective: The current meta-analysis aimed to clarify the association between weight fluctuation and all-cause mortality. Data source: We electronically searched PubMed, Embase, and Web of Science for articles reporting an association between weight fluctuation and all-cause mortality that were published before April 30, 2018. Study appraisal and synthesis methods: The methodological quality of each study was appraised using the modified Newcastle Ottawa Quality Assessment Scale. The hazard ratios (HRs) and corresponding 95% confidence intervals (CIs) were extracted from the included studies and pooled using random-effect models. Meta-regression approaches were also performed to explore sources of between-study heterogeneity. Results: A total of 15 studies were eligible for the current meta-analysis. The pooled overall HR for all-cause mortality in the group with the greatest weight fluctuations compared with the most stable weight category was 1.45 (95% CI: 1.29–1.63). Considerable between-study heterogeneity was observed, some of which was partially explained by the different follow-up durations used by the included studies. Moreover, publication bias that inflated the risk of all-cause mortality was detected using Egger’s test (P= .001). Conclusion: Weight fluctuation might be associated with an increased risk of all-cause mortality.
International Journal of Agriculture and Environmental Research

The present study investigated the concentration of heavy metals (lead (Pb), cadmium (Cd), chromium (Cr), copper (Cu), zinc (Zn), and iron (Fe) in water, sediments, Chrysichthys nigrodigitatus and Macrobrachium macrobrachion from Badagry Creek and Ologe Lagoon, between June and November, 2016. Water, sediment, 90 C. nigrodigitatus and 110 M. macrobrachion were collected and digested using standard method. Fe (178.97±15.48mgL) and Zn (299.63±152.17mgL) concentrations in water of Ologe Lagoon was higher (p<0.05) than that recorded in Badagry Creek (138.16±39.49 mgL 295.71±9.33 mgL). Cd concentration in sediment from Badagry Creek (7.96±4.45μgg) was significantly (p<0.05) higher than that from Ologe Lagoon (5.98±2.48 μgg). Cu, Zn and Fe (7.94±2.58μgg,1543.78±315.04 μgg and 6992.70±3905.63 μgg) respectively in the sediment from Ologe Lagoon were significantly higher than values (4.75±1.28 μgg, 738.29±87.89 μgg and 5330.40±954.31 μgg) recorded in sediment from Badagry Creek. The Zn and Fe content respectively in M. macrobrachion from Ologe Lagoon (42.19±6.02 μgg, 48.77±24.69μg g) was higher (p<0.05) than that from Badagry Creek (21.18±14.28 μgg, 38.74±29.09μgg) while the concentration of Fe in C. nigrodigitatus from Badagry Creek (32.61±13.41μg g) was higher than that from Ologe Lagoon (25.54±12.14 μg g). The Cu, Zn, Fe and Cr in the water column, and Zn and Fe in sediment, C. nigrodigitatus and M. macrobrachion from Ologe Lagoon and Badagry Creek International Journal of Agriculture and Environmental Research ISSN: 2455-6939 Volume: 06, Issue: 03 "May-June 2020" www.ijaer. in Copyright © IJAER 2020, All rights reserved Page 468 exceeded WHO permissible limits. The results indicated that both water bodies are contaminated with heavy metals although more prominent in Ologe Lagoon. Therefore, indiscriminate discharging of untreated effluents into Badagry creek and Ologe Lagoon should be cautioned.
International Journal of Agriculture and Environmental Research

1AgroEcoHealth Platform, International Institute of Tropical Agriculture (IITA), 08 P.O. Box 0932, Tri-Postal Cotonou, Benin. 2Faculty of Science, Department of Biochemistry, University of Yaoundé I, P.O. Box 812, Yaoundé, Cameroon. 3Faculty of Agronomic Science, Department of Nutrition and Foods Science, University of Abomey-Calavi, P.O. Box 526, Cotonou, Benin. 4Faculty of Agronomy, Department of Science, Techniques and Vegetal Production, University of Parakou, P.O. Box 123, Parakou, Benin. 5Ecole Normale Superieure of Natitingou, University of Science, Arts and Techniques of Natitingou, P.O. Box 123, Natitingou, Benin. 6International Institute of Tropical Agriculture (IITA), 08 P.O. Box 0932, Tri-Postal Cotonou, Benin. 7International Institute of Tropical Agriculture (IITA), P.O. Box 34441, Dar-es-Salaam, Tanzania. 8Institute of Agricultural Research for Development (IRAD), Nkolbisson, P.O. Box 2123, Messa-Yaounde, Cameroon.
International Journal of Agriculture and Environmental Research

Salinity is considered a hindrance for growth and productivity of several economic crops worldwide. In this paper we investigate the effects of different concentrations of NaCl (0, 25, 50 and 100 mM) on growth and gene expression of two tomato cultivars differing in salt tolerance, a salt sensitive variety (GS12) and a salt tolerant cultivar (Adora). Salt stress caused GS12 plants to be affected negatively with significant decrease in all growth parameters; meanwhile Adora plants grew in a comparable pattern to control untreated plants. When differential display polymerase chain reaction was applied to test the difference in gene expression in both cultivars, GS12 plants showed down regulation of some genes while, Adora plants showed up regulation of other genes. We managed to identify a zinc finger protein gene and a nitrite reductase gene from Adora tomato plants which appeared to contribute to the ability of these plants to withstand salt stress and grow in a much similar manner like control untreated plants. These two genes could contribute in further studies of tolerance to other stresses when introduced to other crop plants or other tomato cultivars.
A systematic review and meta-analysis

Background:To systematically evaluate the efficacy and safety of sotagliflozin (SOTA) adjuvant therapy for type 1 diabetesmellitus (T1DM). Methods: Through April 2019, the Web of Science, PubMed, Cochrane Library, Embase, and China National Knowledge Infrastructure databases were electronically searched to identify randomized controlled trials exploring SOTA adjuvant therapy for T1DM. Strict screening and quality evaluations of the obtained literature were performed independently by 2 researchers. Outcome indexes were extracted, and a meta-analysis of the data was performed using Revman 5.3 software. Results:A total of 7 randomized controlled trials were included. The meta-analysis results showed that compared with the patients in the placebo group, the patients in the SOTA group had a lower hemoglobin A1c (mean difference [MD]= 0.28, 95% confidence interval [CI] [ 0.34, 0.22], P< .01), lower total daily insulin use (MD= 8.89, 95% CI [ 11.64, 6.13], P< .01), faster weight loss (MD= 3.03, 95% CI [ 3.79, 2.26], P< .01), better fasting blood glucose and 2-hour postprandial blood glucose control (MD= 0.75, 95% CI [ 1.04, 0.45], P< .01; MD= 2.42, 95% CI [ 3.17, 1.67], P< .01), and a higher rate of well-controlled glucose levels (relative risk=1.75, 95%CI [1.55, 1.99], P< .01), while no significant difference in the incidence of severe hypoglycemic events was found between the SOTA and placebo groups (risk difference [RD]= 0.01, 95% CI [ 0.02, 0.00], P= .13). The incidence of diabetic ketoacidosis was higher in the SOTA group than in the placebo group (RD=0.03, 95% CI [0.02, 0.04], P< .01). The incidence of genital mycotic infection was higher in the SOTA group than in the placebo group (RD=0.06, 95% CI [0.05, 0.08], P< .01). No significant difference in the incidence of urinary tract infections was detected between the SOTA group and the placebo group (RD=0.00, 95% CI [ 0.01, 0.01], P=0.97). Conclusions: SOTA is a potential drug for the treatment of T1DM and is effective for controlling blood sugar. The main adverse reactions to SOTA are genital mycotic infections and diabetic ketoacidosis. We must further assess the severity of diabetic ketoacidosis caused by SOTA. Abbreviations: CI = confidence interval, HbA1c = hemoglobin A1c, MD = mean difference, RD = risk difference, RR = relative risk, SE= standard error, SGLT-1= sodium-dependent glucose transporter-1, SGLT-2= sodium-dependent glucose transporter-2, SOTA = sotagliflozin, T1DM = type 1 diabetes mellitus, T2DM = type 2 diabetes mellitus.
International Journal of Agriculture and Environmental Research

Information about genetic diversity is very crucial in plant breeding program because of crosses between parents with high inter-parental diversity may also help to develop varieties with broad genetic base. The genetic diversity and the relationships among 24 Turkish sesame genotypes were evaluated using 14 ISSR primers. The 14 ISSR primers amplified 68 bands of which 46 were polymorphic (68.2%). The polymorphism information contents (PIC) value, is the discriminatory power of the primers and used as a relative measure level of polymorphism, ranged from 0.06 0.70 with an average of 0.32. The 24 sesame genotypes were divided into 3 groups in a UPGMA based dendogram. Cluster A included 9 sesame population from different region of Turkey, while cluster B included only 5 sesame population from Adana province and two commercial cultivars (Muganli-57 and Baydar-2001). As to cluster C consist of 5 commercial cultivar which registered by same institute and three sesame population from east part of Turkey. This study gives some useful information about the genetic diversity of 24 sesame landraces. The variation harbored by these landraces could be used in sesame breeding program in Turkey as well as in the world. ISSR primers grouped some landraces based on their geographical provenances and while cluster others showing that ISSR could be useful in geographical clustering of sesame landraces.
International Journal of Agriculture and Environmental Research

Beekeeping is an important activity to increase the family income in rural areas. However, honey bees pests and their control measurements is a great challenge. Despite the extensive use of insecticide to control the greater wax moth Galleria mellonella is the most distructive insect pests of honey bees in the tropic. Hence the present a study was aimed to test the entomopathogenic fungus Beauveria bassiana as microbiological control agent against G. mellonella. The third larvae instars were tested against different fungal suspension spores concentrations which were prepared from sub culture in the Microbial Pesticides formulation Unit (National Centre for Research) during the period from (2014-2015). The obtained result showed G. mellonella larvae were highly susceptible to the infection of B. bassiana. High mortality (20-100%) was achieved using different concentrations at exposure time of 11 days under laboratory condition (60-70 RH and 25C°±2). Mortality mean was significantly different among concentrations (F= 35.75, P < 0.05) and significantly higher in all the concentrations in comparison to control. The LC50 that can kill 50 % of G. mellonella larvae after treatment with 5μL of B. bassiana ITCC 6628 at different concentrations was estimated to be 01.40 × 107 conidia /mL . The LT50 was estimated at different concentration. The highest pathogenicity was obtained by concentration of 01× 109 conidia /ml at estimate LT50 value of 7 day and 12 hours. The present study clearly showed that B.bassiana is a promising biological control agent against G. mellonella, but this finding needs more investigation in the field of non-selectivity and formulation improvement of B. bassian.
International Journal of Agriculture and Environmental Research

The current work was done during the two successive summer seasons 2016 and 2017 at Experimental farm of Agricultural Research Center, Ismailia, Egypt. Five genetically diverse sesame genotypes namely; A1B5(P1), H133A4(P2), line 363(P3), Shandaweel -3(P4), and Sohag(P5) were crossed in a half diallel breeding pattern to obtain ten F1 hybrids excluding reciprocals and were evaluated during summer season of 2017. The 15 genotypes viz, the 5 parents and 10 F1s were raised in a randomized complete block (RCB) design with three replications. Highly significant differences were observed among genotypes for all studied traits. The performance of the parents P3, P4, P5, and the crosses P3×P4, P3 X P5, P4×P5 and P2×P3 were the best genotypes for yield and its components. Mean squares for both general (GCA) and specific (SCA) combining ability were significantly higher for all the studied characters. The ratios of GCA/SCA were less than unit for plant height; capsules weight plant, 1000-seed weight and seed yield plant. While, in case of remaining characters the magnitude of SCA was higher than GCA. This indicates presence of adequate amount of variation in parents and crosses. The three parentsP3, P4 and P5 could be considered as the best general combiners for seed yield. However, the crosses P2×P5, P3×P4, and P3×P5 had the most desirable SCA effects for seed yield plant and the most studied traits and the same crosses also showed the highest heterosis percentage over the mid-parent values for seed yield. The association between seed yield and its contributing characters indicated that the seed yield had positive and significant association with the most studied traits. Path coefficient analysis revealed maximum positive direct effect of 1000-seed weight per plant (0.781), number of seeds per capsule on seed yield followed by seed oil content (0.442), capsules weight per plant (0.427) and plant height (0.414) showed high positive direct effects on seed yield. Selection for the traits with positive association and direct International Journal of Agriculture and Environmental Research ISSN: 2455-6939 Volume:05, Issue:01 "January-February 2019" www.ijaer. in Copyright © IJAER 2019, All rights reserved Page 131 effects will be useful for the improvement in yield of sesame through breeding program. High heritability in broad sense was observed for all studied traits.
International Journal of Agriculture and Environmental Research

Soil biochar application effects on warmand cool-season crops are not well understood. Corn (Zea mays L.), soybean (Glycine max L.), wheat (Triticum aestivum L.), cereal rye (Secale cereal L.), and alfalfa (Medicago sativa L.) were grown in a Marietta fine sandy loam (fine-loamy, siliceous, active, thermic Fluvaaquentic Eutrudept) and a Houston silty clay (very fine, smectitic, thermic Oxyaquic Haplaudert) amended with 0, 45, 90, and 180 Mg ha of pine biochar and allowed to equilibrate for 56-d. To investigate a possible nitrogen effect, three nitrogen rates (0, 0.5 and 1.0X of the recommended rate for each crop) were added to non-legume species at planting. Legume crops were inoculated with Brady Rhizobia upon planting. All species were pre-germinated for 14-d in sand trays. After 21-d growth in the treatments, plants were harvested and shoots were analyzed for shoot dry weight, nutrient uptake and concentration, and forage quality. Decreases in uptake of nitrogen (N), phosphorus (P), potassium (K), magnesium (Mg), and calcium (Ca) were found for corn, soybean and alfalfa in both soils at higher rates of biochar (90 and 180 Mg ha). Changes in forage quality were specific to soil, crop and parameter and clear trends were not apparent. This study found biochar amendment decreased plant nutrient uptake, and affected forage quality. Thus, the appropriateness of biochar incorporation depends on the nature of the cropping system in which it is to be used.
I nternational J ournal of Agriculture and Biosciences

Nanochemistry has its diverse applications in the field of food science and technology. Various nano particle acts as anti-bacterial agents in active packaging of food. The application of these active packaging containing nanoparticles in it plays a vital role in the protection, preservation and enhancement in the shelf life of food. Silver nano particles (AgNPs) and Zinc Oxide nanoparticles (ZnO NPs) can be easily mixed with bio-polymer and synthetic polymers used for packaging materials. These nanoparticles act as anti-microbial agent to enhance the shelf life of food products. This review presents the effect of various physical factors including size, concentration, morphology, pH, surface charge and strain specific activity upon the anti-bacterial activity of AgNPs and ZnO NPs against five gram positive Staphylococcus aurerus ( S. aurerus ), Listeria monocytogenes (L. monocytogenes), Streptococcus pneumoniae(S .pneumoniae) , Enterococcus faecalis ( E. faecalis), Bacillus subtilis ( B.subtilis ) and five gram negative Escherichia coli ( E. coli ), Pseudomonas aeruginosa (P. aeruginosa), Salmonella typhimurium (S. typhimurium), Klebsiella pneumonia (K. pneumoniae ), Klebsiella aerogenes (K. aerogenes) strains are presented. Furthermore, practical approaches for addition of AgNPs and ZnO NPs in edible and inedible coating of various food products to enhance the shelf life of food materials is also presented. It is important to address all possible health effects caused by nanoparticles to ensure food safety. Therefore, this review also presents regulation and limitation of different regulating bodies’ sets for Ag and ZnO NPs.
Comparison of Some Soil Properties in One Forest and Two Grassland Ecosystems on Mount Meru, Tanzania

In the Forest Belt on the eastern slopes of Mt. Meru, patches of open grassland exist within the forest. Previously, these grasslands were kept open by fire and grazing, but, since this part of the mountain was included in the Arusha National Park, it is probably mainly grazing by buffaloes that prevents the forest from invading parts of the open plots. In this investigation a number of chemical and physical soil properties were studied under three vegetation types-one heavily grazed area, where the grass Cynodon dactylon dominates, one area which is dominated by tall, non-grazed tussock grasses, Eleusine jaegeri and Setaria trinervia, and finally an adjacent forest area. The soil properties under the three vegetation regimes are compared. The age and origin of the grassland areas are discussed in light of the edaphic factors and findings of pieces of clay pottery and charcoal in the soil.
Prevalence of Stunting and its Biosocial Determinants among Young Children Enrolled at Urban Anganwadi Centers in Rishikesh, Uttarakhand

Background: Stunting is a significant public health problem in childhood in developing countries. Sustainable Developmental Goals have mandated that each country reduce stunting by 50% by 2030. However, despite various nutrition and health programs, India still faces a massive burden of stunting. With the increasing urbanization in the country and its typical challenges related to health and nutrition, chronic malnutrition is a massive problem in urban areas, especially among people in the lower wealth quintile. Hence, current study has attempted to estimate the prevalence of stunting among children (0–6 years) and its determinants. Methodology: A cross-sectional study was conducted in the Urban Anganwadi centers of Rishikesh, Uttarakhand, for 6 months, from December 2021 to May 2022. Three hundred ten children from 13 selected Anganwadi centers were included using random sampling. Data were collected using a semi-structured validated and pretested questionnaire using Epicollect 5.0. Data were analyzed using the SPSS 23.0 version to estimate the prevalence of stunting and associated risk factors. Results: Out of 310 participants, 71 (22.9%) were stunted. Female children were slightly more stunted (24.7%) than males (21.1%). Maximum stunting (33.4%) was observed among children in the 5–6-year age group, and children with higher birth order were much more stunted. Stunting was reported more in children who were breastfed on demand (33.8%) than those fed every 2 hours (19.3%). Conclusion: Stunting prevalence in urban areas of Rishikesh is 22.9%, which is almost similar to the state average of 24.3% for urban areas; however, it was higher in comparison to the SDG 2030 global target of ending malnutrition of all forms. Stunting was significantly associated with feeding on demand and eating frequency less than twice a day.
Advance Publication by J-STAGE Journal of Reproduction and Development

22 Ovaries contain follicles at various stages of development, including primordial, primary, secondary, 23 antral and Graafian follicles. Although the growth of these follicles is controlled to maintain regular 24 ovulation, the mechanism through which this occurs remains unclear. In our study, we found that the 25 growth rate of cultured secondary follicles separated from mice ovaries differed between follicles. 26 After 4 days of culture, the size of some secondary follicles was markedly increased, while that of 27 others had either slightly increased, remained unchanged or shrunk. We compared the expression 28 levels of growth factors between these secondary follicles and found that the growth rate of cultured 29 secondary follicles correlated with the expression level of insulin-like growth factor 1 (Igf1) mRNA. 30 Igf1 mRNA expression level in secondary follicles containing theca cells was higher than that in 31 secondary follicles without theca cells, and the granulosa cell proliferation around follicles containing 32 theca cells was increased. Furthermore, an IGF1 inhibitor also inhibited the granulosa cell 33 proliferation, and administration of IGF1 to secondary follicles without growth promoted granulosa 34 cell proliferation. These results indicated that the theca cells of secondary follicles induced the 35 expression of IGF1 and promoted the follicle growth. 36 37