Miracle-dz/UniFAR-FTUs huggingface dataset:
PTPRO predicts patient prognosis and correlates with immune infiltrates in human clear cell renal cell carcinoma

Background The tumor-suppressive role of protein tyrosine phosphatase receptor type O (PTPRO) has been described in a variety of human cancers; however, the clinical significance of PTPRO in human clear cell renal cell carcinoma (ccRCC) remains unclear. Methods PTPRO expression in renal cell carcinoma (RCC) was analyzed via the Oncomine database, Gene Expression Omnibus (GEO) datasets, and The Cancer Genome Atlas (TCGA) datasets. The Kaplan-Meier curves and Cox proportional hazards model were used to evaluate the relationship of PTPRO with overall survival in ccRCC. Gene ontology (GO) analysis and gene set enrichment analysis (GSEA) were performed to explore the signaling pathways in which PTPRO may be involved. The correlation between PTPRO and immune infiltrates in ccRCC was investigated via Tumor Immune Estimation Resource (TIMER) database. The association between PTPRO mRNA expression and its methylation in RCC was analyzed using the Cancer Cell Line Encyclopedia (CCLE) dataset, GEO dataset, and cBioPortal database. The impact of PTPRO methylation on overall survival was estimated by the MethSurv database. Results We showed that the expression of PTPRO was significantly lower in human RCC. Moreover, the lower expression of PTPRO was associated with worse overall survival in ccRCC, particularly in the advanced stage patients. Multivariate Cox regression analysis revealed the expression of PTPRO as an independent prognostic predictor for overall survival of ccRCC. Of note, PTPRO was found to be associated with the activation of immune signaling and immune cell infiltration. Furthermore, methylation of PTPRO was prevalently observed in ccRCC, and methylation of PTPRO predicted the poor outcome of ccRCC. Conclusions Our findings suggested that PTPRO at both RNA and DNA methylation levels had the potential as a prognostic biomarker for predicting prognosis, and PTPRO expression was closely associated with immune infiltration in ccRCC patients.
The role of E-cadherin in the regulation of myelination in the peripheral nervous system

In the mammalian nervous system, saltatory conduction is necessary for rapid velocities of action potentials down long axonal trunks. Myelination is the key to this near instantaneous transmission of signals. Oligodendrocytes of the central nervous system and Schwann cells of the peripheral nervous system, are the cells that myelinate axons. While there is some understanding of how these cells concentrically wrap their plasma membranes around the axon to form this insulative layer, the precise induction mechanism is not clearly determined. A potential molecule involved in this process is E-cadherin, which has been previously identified to be localized to regions of compact myelin and various adhesion enriched areas. This study focuses on the role of E-cadherin, a member of the classical cadherin family of calcium dependent adhesion molecules, and its role in the initiation of myelination in the Schwann cells. Protein lysates of rat sciatic nerve demonstrate that expression of E-cadherin was shown to increase with development and that E-cadherin associated with ErbB2, a receptor tyrosine kinase known to function in Schwann cell development, promotes proliferation and myelination. Knockdown of E-cadherin has a negative effect on myelination in vitro, while ectopic expression of E-cadherin induces myelination. Additionally, upon iii perturbation of beta catenin binding to E-cadherin, enhanced proliferation and myelination was observed. This enhancement was found specifically in Superior Cervical Ganglion neurons (SCG), suggesting that beta-catenin coupling may also have an effect in myelination through an un-determined cadherin-catenin mechanism. These results suggest that cadherins have a critical role in the complex process of myelination. iv Acknowledgements
Use of Insulin in treatment of COVID-19: A proposal to explore feasibility

COVID 19 has a major impact in European countries and in United States of America. Presently there are more than 15 million cases worldwide with a death toll of more than0.6 million. (4) Currently the number of COVID 19 positive cases is rapidly rising in India. As of today, there is no curative medication for COVID 19.Patients with mild symptoms recovers with supportive medication. Patients with moderate to severe symptoms, especially the elderly or with comorbidities may develop severe COVID 19. They are currently treated with number of experimental and repurposed medications. These patients may have high mortality rates. (5) We scrolled through the literature to analyse the role of Insulin in the treatment of COVID-19.
Cities, Industrialization, and Job Creation: Evidence from Emerging Economies∗

In this paper, we estimate multipliers of jobs in the tradable sector on non-tradable employment in cities in Brazil, China, India, Mexico, and South Africa. Building on an emerging literature on local labour multipliers, we show that average multipliers in emerging economies are smaller relative to existing estimates for the United States, while the multiplier for skilled jobs is 6 to 9 times larger both according to simple OLS estimates and when using an instrumental variable strategy that exploit nation-wide changes in employment and initial cross-city industry specialization. While there is growing concern that the manufacturing sector is not absorbing as many workers as it once did, we document that its indirect impact on service employment is substantial. We further conclude that emerging economies can generate significantly more jobs in the nontradable sector by shifting towards more skill-intensive production. JEL: J23, R11, R12, R23
STUDY OF ANTECEDENTS OF PURCHASE INTENTION AND ITS EFFECT ON BRAND LOYALTY OF PRIVATE LABEL BRAND OF APPAREL

With a positive growth rate of the Indian GDP since 2003, many of the foreign retailers are trying to set up their store in India. This has also led to the growth of the organized retail in India. The growth of the organized retail has also led to the growth of the private label brands. Private label brands are cheaper and better in quality. The retailers also have a control over the private label brands which also helps in branding the retail outlet. In this paper the researcher wants to find out if the parameters of store brand quality, perceived value, social risk, functional risk andfinancial risk has an impact on the purchase intention of the customer of private label brand of Apparel He also wants to find out if the purchase intention of the customer in turn has an impact on developing brand loyalty. In the study it has been found out that store brand quality and perceived value has an impact on the purchase intention. Purchase intention also impacts brand loyalty in future. Method Primary research is used for the study to collect data of the customers buying private label brand of apparel.
Integration of different weed management practices for increasing yield of finger millet (Eleusine coracana L. Gaertn)

In order to investigate the effect of different herbicidal treatments on finger millet crop, a field experiment was carried out in randomized block design with three replication during 2015 at IGKV, Rajmohini Devi College of Agricultural and Research Station, Ambikapur (C.G). Weeds, viz. Panicum maxima, Elusine indica, Cyperus spp. , Cynodon dactylon, Celosia argentea, Alternanthera sessilis, Alternanthera triandra and Ageratum conyzoides were the dominant weeds of the experimental field. Results revealed that number of tillers, LAI, dry matter accumulation, crop growth rate per plant, weed control efficiency, herbicide use efficiency and grain yield were significantly higher under hoeing twice by wheel hoe between rows and intra-row manual weeding at 20 and 40 and hand weeding twice at 20 and 40 DAS.
New Born Care Practices in a Resettlement Colony of Delhi

Background: Newborn death accounts for 40% of all deaths among the under five children. Most of the newborns are born and die at home in developing country. Newborn health intervention trials at the home and community is identified as one of the key strategy to prevent most newborn death. Objectives: The study was conducted to assess the newborn care practices and the associated factors among the mothers of resettlement colony in Delhi. Method: Cross sectional study was conducted among mothers of newborn in an urban slum of East Delhi. Systematic random sampling method was adopted to interview 360 mothers who had live newborns under 28 days old. The data was collected using a pretested, validated and semi structured questionnaire . Appropriate statistical tests were applied. Results: Among 360 study participants, 206(57.2%) preferred home delivery and 154(42.7%) of deliveries was conducted by skilled birth attendant. 31.1% of newborns were dried immediately. The cord was cut after the delivery of placenta among 189(52.5%) of the newborns. 85.3% of mothers something applied on the cord. 18.1% of mothers discarded colostrum. 81.9% of newborns were given prelacteal feeding. Mothers literacy, birth order, no of antenatal visits, place of delivery were significantly associated with the newborn care practices. Conclusion: It is observed that detrimental newborn care practices were more common than the beneficial practices in the study. Understanding newborn care practices at home and community level is essential to improve existing intervention to reduce neonatal mortality.
Identification of fatigue-related kinematic changes in elite runners using a support vector machine approach

Understanding the kinematic changes underlying fatigue is essential in running biomechanics. The aim of this study was to identify fatigue-related kinematic changes in elite runners using a support vector machine approach. Full-body kinematics of thirteen trained runners were recorded in a non-fatigued and a fatigued state during treadmill running at their individual fatigue-speed. A support vector machine was trained and used to identify kinematic differences between the non-fatigued and fatigued state based on principal component scores. Strides during non-fatigued and fatigued running could be separated with 99.4% classiﬁcation accuracy. Four upper limb (two shoulder and two elbow), four lower limb (one ankle, two knee and one hip) and two trunk (one thoracic and one lumbar spine) principal component scores were identified as most discriminative kinematic features between non-fatigued and fatigued running. The findings of the study suggest the feasibility of a support vector machine approach to identify subtle fatigue-related kinematic changes in elite runners.
Bedside Endorsement Of Patients (Beep): A Tool to Enhance Communication and Patient Involvement, a Critical Component of Patient Safety Culture

Introduction: Communication-related to care, treatment, and services with the patient and family serves as the vital characteristic of a culture of safety in the hospital setting. Reports have revealed a lack of communication or breakdown of communication to be the leading cause for 70% of all sentinel events. Kuwaitis represent only 6% of the countries nursing workforce, and only 30% of the doctors, most of the expatriate working force comes from non-Arab speaking countries. Standardizing shift changes and doing endorsements at the bedside is an attempt to reduce this communication gap among patients and their care providers. Methods: The current study thus attempts to assess the efficiency of Bedside Endorsement of Patients (BeEP) in promoting communication and patient involvement, both of which serve as critical components of patient safety culture. It is believed that once a high level of communication and patient involvement is established there will be a significant enhancement in patient satisfaction along with reduction in the patient and family anxiety. Result: The study results revealed BeEP implementation increases patient's awareness on multiple aspects related to their care such as knowledge of shift change timings, nurse name, dietary restrictions, medication course and time, doctors round timings, discharge date and plan of the day. Conclusion: An increase is thereby noted in terms of patient and family involvement in their care and timely response to patient’s inquiry resulting in increased satisfaction. Bedside endorsement of patients thus poses as the most suitable method to enhance communication as well as bridge communication gap between the nurses and the patients and to increase patient and family involvement.
MicroRNA-374 is a potential diagnostic biomarker for atherosclerosis and regulates the proliferation and migration of vascular smooth muscle cells.

Background The occurrence and development of atherosclerosis (AS) are closely related to the abnormality of vascular smooth muscle cells (VSMCs), and multiple microRNAs (miRNAs) have been reported to participate in the pathogenesis of AS. This study explored the expression and clinical value of miR-374 in the serum of AS patients, and analyzed its effect on the proliferation and migration of VSMCs. Methods The expression levels of miR-374 in the serum of 102 asymptomatic patients with AS and 89 healthy patients were detected by fluorescence quantitative PCR. The diagnostic value of miR-374 was evaluated through the receiver operating characteristic (ROC) curve. What's more, CCK-8 and Transwell assays were used to analyze the effects of miR-374 on the proliferation and migration of VSMCs. Results The expression level of miR-374 in the serum of AS patients was significantly higher than that of the control group. At the same time, the expression of miR-374 in AS patients was positively correlated with carotid intima-media thickness (CIMT). The area under the ROC curve is 0.824. Furthermore, overexpression of miR-374 significantly promoted the proliferation and migration of VSMCs, whereas reducing miR-374 inhibited the proliferation and migration of VSMCs. Conclusions The high expression of miR-374 may be a potential diagnostic marker for AS, and overexpression of miR-374 may play a role in AS by promoting the proliferation and migration of VSMCs.
Diversity of fishes in Beles and Gilgel beles Rivers, abay basin, Ethiopia

Diversity of fish species of Beles and Gilgel Beles Rivers were studied. Fishes were sampled using gill nets of various stretched mesh sizes, and hooks and lines. Identification of fish was made to species level by comparing the sample characters with taxonomic keys found in literatures and specimens deposited. Shannon diversity index (H`) was used to evaluate species diversity of fishes. A total of 1124 individual fishes belonging to 5 orders, 7 families, 13 genera and 23 species were caught in Beles and Gilgel Beles Rivers. Cyprinidae was best-represented family with the highest number of fish species in the rivers while Labeo and Labeobarbus were the best-represented genera. A higher number of species were recorded in the Beles River (22 species) than in the Gilgel Beles River (5 species). The diversity index was higher in the Beles River (H´=2.43) than in the Gilgel Beles River (H´ = 0.88). In general, Beles River is richer than Gilgel Beles River, in terms of total numbers of fish caught and number of species recorded. In order to have a better knowledge of the fish populations in the study area, further studies are required on diversity, abundance and biology of the fishes. Therefore, sustainable utilization and conservation measures should be taken in the two rivers.
BACKSWING LENGTH AND SWING PATH TENDENCIES FROM AMATEUR GOLFERS

The purpose of this study was to identify if shorter backswings off the tee influence the ‘outside-in’ ball impact (i.e. tendency to slice, fade or pull). Participants motion data were obtained on a reduced-size driving range, using a SmartSwing driver club (3D data sampling at 1000 Hz). Findings from a representative sample of the amateur golfers’ population (N=13, 531 swings) indicate a pattern where a shorter backswing reduced the tendency for ‘outside-in’ (-17.8%) while increasing ‘parallel’ (+6.9%) and ‘inside-out’ ball impacts by (+10.8%). For golfers who suffer from repetitive overuse or ageing-related reduced range movement or back pain, shortening the backswing is a viable option when considering safety and risk of injury. The findings can help golf swing coaching, as well as competitive/strategic and recreational aspects of self-management.
Sodium–glucose cotransporter 2 inhibitors (SGLT2Is) – The latest residents on the block: Impact on glycaemic control at a general practice level in England

Citation for published version (APA): Heald, A. , Fryer, A. A. , Anderson, S. , Livingston, M. , Lunt, M. , Davies, M. , Moreno, G. Y. C. , Gadsby, R. , Young, R. J., & Stedman, M. (2018). Sodium–glucose cotransporter 2 inhibitors (SGLT2Is) – The latest residents on the block: Impact on glycaemic control at a general practice level in England. Diabetes, Obesity and Metabolism, 20(7), 1659-1669. https://doi.org/10.1111/dom.13281
Habitat and landscape-scale effects on the abundance and diversity of macro-moths (Lepidoptera) in intensive farmland

Since 1968 UK macro-moths have declined by 28%, with the most notable trends revealed for the south of England; the dual influences of climate change and intensive land use are thought to be the main drivers for this trend. This study aimed to determine the landscape and local-scale factors influencing moth abundance and species richness in intensive Northamptonshire farmland. The research consisted of four parts: 1. the analysis of historic county moth records using landscape-analysis, 2. Moth trapping in areas of intensive lowland farmland and subsequent local and fine-scale landscape-scale analysis of trap yields, 3. Moth movement studies along farmland hedgerows and 4. Moth visitation surveys of hedgerow flora. The results of the analysis of county moth records revealed that land-use statistics had a highly significant relationship with the abundance of moths across Northamptonshire. Woodland cover was found as having a positive relationship with the abundance of moths, but that urban cover was negatively associated. The farmland moth trapping study recorded a total of 121 species, the majority of which were generalist (98%) and none of which have Biodiversity Action Plans. For this trapping, hedgerow length, width and cross-sectional area, vegetative diversity and the numbers of hedgerow gaps all had an influence on the abundance of some of the species trapped, but no hedgerow or margin variables had a significant influence on overall abundance or species richness. Moth movement surveys found that a significant proportion of moths were travelling parallel along hedgerows (69% of moths observed at 1m from the hedgerow) in farmland and that moth activity was higher close to hedgerows. Nocturnal visitation surveys of hedgerow flora found that 53% of visitors were Lepidoptera and that the most visited species was Bramble (Rubus fruticosus agg.). The results of the combined studies suggest that land use influences moth abundance at a range of spatial scales and that hedgerows may be providing sheltered dispersal routes and nectar resources for these species.
TRANSVERSE PLANE HEAD-TRUNK COORDINATION DURING ANTICIPATED AND UNANTICIPATED SIDESTEPPING TASKS

The purpose of this study was to examine head control during anticipated and unanticipated sidestepping tasks. Twelve collegiate male soccer players performed seven anticipated and seven unanticipated sidestepping tasks. Head and trunk orientation and coordination were assessed during the preparatory and stance phases of the change of direction stride. The head and trunk were less oriented toward the new travel direction with reduced planning time. During the change of direction stride, participants aligned the head with the new travel direction but the trunk lagged behind to a greater extent during the preparatory phase when planning time was reduced. No differences in head and trunk coordination patterns were reported during the stance phase. These different head and trunk orientation and coordination patterns may impact perceptual awareness and potential for injury.
Connective Financing

This paper studies the causal effect of transport infrastructure on the spatial concentration of economic activity. Leveraging a new global dataset of geo-located Chinese government-financed projects over the period from 2000 to 2014 together with measures of spatial inequality based on remotely-sensed data, we analyze the effects of transport projects on the spatial distribution of economic activity within and between regions in a large number of developing countries. We find that Chinese-financed transportation projects reduce spatial concentration within but not between regions. In line with land use theory, we document a range of results which are consistent with a relocation of activity from city centers to their immediate periphery. Transport projects decentralize activity particularly strongly in regions that are more urbanized, located closer to the coast, and less developed.
A Revision of the Woolly Monkeys (Genus Lagothrix)

A study of 312 specimens of woolly monkeys and all known literature records reveals that the genus Lagothrix consists of two allopatric species, L. lagothricha , relatively widespread in the upper Amazonian basin and adjoining regions, and L. flavicauda (= hendeei Thomas), restricted to a pocket on the eastern slope of the Cordillera Central in northern Peru. Four races of L. lagothricha are recognized, as follows: L. l. lagothricha , uniformly brownish on head and body, distributed north of the Rio Amazonas and east of the Rio Napo; L. l. poeppigii , reddish brown with a contrastingly darker head, distributed west of the Rio Napo and Rio Jurua; L. l. cana , olivaceous with a contrastingly darker head, distributed east of the Rio Jurua and south of the Rio Amazonas; L. l. lugens , ranging in color from uniformly pale silver-gray to blackish, distributed in Colombia along the eastern slope of the Cordillera Oriental and in the upper Rio Magdalena basin. L. flavicauda , deep mahogany with a yellow-streaked tail and also distinguished by cranial characters, is monotypic. Information is given on dentition, breeding records and habits.
Regulation of zinc homeostasis by nitric oxide, glutathione and sulphydryl groups in plants

The present research was aimed to investigate whether Nitric Oxide (NO) is involved in zinc homeostasis in plants. It also aimed to study the involvement of GSH, SH groups and NO in mediating changes in zinc homeostasis. Wheat seeds (Triticum aestivum L., cv. giza-167) and bean seeds (Phaseolus vulgaris, cv. Bronco) were germinated and grown in vermiculite watered with nutrient solution. Zinc was supplied in different concentrations (0.5, 2.7, 5.4 (control), 10.8 and 21.6 μM as ZnSO4). Sodium nitroprusside (SNP) was used as NO donors in a 100 μM concentration and methylene blue (MB), in a 100 μM concentration, was used as NO scavengers. The solutions were supplied to plants by irrigation once a week included in the nutrient solution. 21-d-old plants were harvested. The results revealed that SNP application (NO donor) alleviated the adverse effect of deficient and toxic levels of zinc concentrations by increasing shoot and root biomass allocation, RGI% and protein content. Moreover, SNP application maintains a suitable zinc concentration in both deficient and toxic levels of zinc supplies in both wheat and bean seedlings. Nitric oxide induced significant changes in total and free/total SH, GSH content and SOD activity. The effect of nitric oxide was supported by using MB which scavenges the endogenous nitric oxide. The effect of NO is suggested to be a result of the adjustment of total or free SH levels, glutathione content and superoxide dismutase (SOD) activity.