Miracle-dz/UniFAR-FTUs huggingface dataset:
Infrared, transient thermal, and electrical properties of silver nanowire thin films for transparent heaters and energy‐efficient coatings

In this study, we investigate the infrared and electrical properties as well as the thermal response of transparent silver nanowire (AgNW) based thin‐film heaters, when subjected to Joule heating. Controlling the number of layers and hence the deposition time, our spray‐coating technique allows to modulate the thermal and electrical properties of the thin films in a precise manner. In addition, this technique enables the fabrication of homogeneous and large‐area heaters, which, in terms of their electro‐optical properties, nicely compare to the performances of state‐of‐the‐art AgNW transparent electrodes. The thermal response and the electrical properties are accurately reproduced by a purposely developed physical model, which shows that the temperature dependence of the AgNW film resistance is lowered by a factor of 2 compared to bulk silver, independently of the number of deposited layers. Compared to uncoated glass, the emissivity decreases by 58% at a coverage rate of 58%. At the same time, the AgNW film can sustain a transparency as high as 81.3%. Therefore, AgNW‐based thin films can be used as a low‐emissivity coating, for e.g., energy‐efficient window glazing applications. Finally, we accurately determine the fragmentation temperature of AgNWs, which sets the ultimate limitation of use for heating applications.
Risks and benefits of oral modified‐release compared with oral immediate‐release opioid use after surgery: a systematic review and meta‐analysis

Prescription of modified‐release opioids for acute postoperative pain is widespread despite evidence to show their use may be associated with an increased risk of adverse effects. This systematic review and meta‐analysis aimed to examine the available evidence on the safety and efficacy of modified‐release, compared with immediate‐release, oral opioids for postoperative pain in adults. We searched five electronic databases from 1 January 2003 to 1 January 2023. Published randomised clinical trials and observational studies on adults who underwent surgery which compared those who received oral modified‐release opioids postoperatively with those receiving oral immediate‐release opioids were included. Two reviewers independently extracted data on the primary outcomes of safety (incidence of adverse events) and efficacy (pain intensity, analgesic and opioid use, and physical function) and secondary outcomes (length of hospital stay, hospital readmission, psychological function, costs, and quality of life) up to 12 months postoperatively. Of the eight articles included, five were randomised clinical trials and three were observational studies. The overall quality of evidence was low. Modified‐release opioid use was associated with a higher incidence of adverse events (n = 645, odds ratio (95%CI) 2.76 (1.52–5.04)) and worse pain (n = 550, standardised mean difference (95%CI) 0.2 (0.04–0.37)) compared with immediate‐release opioid use following surgery. Our narrative synthesis concluded that modified‐release opioids showed no superiority over immediate‐release opioids for analgesic consumption, length of hospital stay, hospital readmissions or physical function after surgery. One study showed that modified‐release opioid use is associated with higher rates of persistent postoperative opioid use compared with immediate‐release opioid use. None of the included studies reported on psychological function, costs or quality of life.
Predictive value of the geriatric nutrition risk index for postoperative delirium in elderly patients undergoing cardiac surgery

Abstract Aims The aims of the study were to determine the relationship between preoperative geriatric nutritional risk index (GNRI) and the occurrence of postoperative delirium (POD) in elderly patients after cardiac surgery and to evaluate the additive value of GNRI for predicting POD. Methods The data were extracted from the Multiparameter Intelligent Monitoring in Intensive Care (MIMIC‐IV) database. Patients who underwent cardiac surgery and were aged 65 or older were included. The relationship between preoperative GNRI and POD was investigated using logistic regression. We determined the added predictive value of preoperative GNRI for POD by measuring the changes in the area under the receiver operating characteristic curve (AUC) and calculating the net reclassification improvement (NRI) and integrated discrimination improvement (IDI). Results A total of 4286 patients were included in the study, and 659 (16.1%) developed POD. Patients with POD had significantly lower GNRI scores than patients without POD (median 111.1 vs. 113.4, p < 0.001). Malnourished patients (GNRI ≤ 98) had a significantly higher risk of POD (odds ratio, 1.83, 90% CI, 1.42–2.34, p < 0.001) than those without malnutrition (GNRI > 98). This correlation remains after adjusting for confounding variables. The addition of GNRI to the multivariable models slightly but not significantly increases the AUCs (all p > 0.05). Incorporating GNRI increases NRIs in some models and IDIs in all models (all p < 0.05). Conclusions Our results showed a negative association between preoperative GNRI and POD in elderly patients undergoing cardiac surgery. The addition of GNRI to POD prediction models may improve their predictive accuracy. However, these findings were based on a single‐center cohort and will need to be validated in future studies involving multiple centers.
The Validity and Reliability of the Rear Foot Elevated Split Squat 5RM to Determine Unilateral Leg Strength Symmetry

The purpose of this study was to examine the validity and reliability of the Rear Foot Elevated Split Squat (RFESS) five repetition maximum (5RM) test as a field method for measuring unilateral leg strength symmetry. As a validated method of testing symmetry, the RFESS 5RM may be used by Strength and Conditioning coaches and sports medicine staff to measure the presence of imbalances with minimal equipment and time. 26 subjects (age = 23.8 ±4.6 years, mass = 88.1 ±10.7kg, height = 1.79±0.1m) with a minimum two years strength and conditioning experience were recruited. Following a familiarization session, subjects performed an incremental five repetition maximum (5RM) protocol on both legs, on two occasions where 3D motion and force data were collected. Moderate reliability of bar load symmetry was found between test and re-test conditions correlation (ICC = 0.73, 0.33-0.91) with no proportional bias between sessions. Validation of the exercise was analyzed using a correlation between asymmetries in mean set vertical ground reaction forces (vGRF) of the lead foot during the concentric phase, with bar load. When all maximal trials, from both test conditions, were analyzed, a most likely large positive correlation (0.57, 0.30 to 0.76) were found for mean set concentric lead foot vGRF. When a threshold level of load symmetry (96.54% - 103.46%) was applied, a most likely large positive correlation (r = 0.59, 0.14-0.84) between symmetry in lead foot vGRF was found in subjects who exceeded this limit. Conversely, analysis of subjects within the threshold produced unclear correlations. Findings of this study suggest the RFESS is a valid and reliable measure of unilateral leg strength symmetry. Practitioners are recommended to use this exercise to investigate the strength symmetry of athletes, but are guided to note that a threshold level of symmetry (96.54% - 103.46%) may be required to have been exceeded to indicate a true difference in vGRF production.
Investigation on improved water-loaded diagonal horn applicators for hyperthermia

Abstract This paper describes simulation, theoretical, and/or experimental studies of specific absorption rate (SAR) distribution in biological phantom (muscle)/tri-layered bio-media without and with irregular-shaped tumors in direct contact with improved water-loaded metal diagonal horns designed at 2450 and 915 MHz. Further, thermal simulation results based on Pennes’ bio-heat equation are also provided for each of the proposed applicators, which is in direct contact with realistic tri-layered bio-media without and with irregular-shaped tumor embedded within the muscle layer. The proposed horns are improved versions of the respective conventional metal diagonal horns in which the aperture fields, which are modified by introducing four conducting pins at appropriate locations near each antenna aperture, correspond to fundamental and higher order modes. The theoretical aperture field distributions of the proposed horns designed at 2450 and 915 MHz are compared with the corresponding simulated ones. Further, the theoretical SAR parameters (penetration depth (PD) and effective field size (EFS)) in the phantom muscle medium due to the proposed horns designed at 2450 and 915 MHz are compared with the corresponding simulated and/or experimental results as well as with those obtained due to the corresponding conventional horns of identical dimensions. Moreover, effects on PD, EFS/EFS25, and temperature distribution profiles due to presence of irregular-shaped tumor in the tri-layered bio-media at 2450 and 915 MHz are also investigated. It is demonstrated that desired temperature range 41–45 °C can be achieved and maintained for 60 min with input power of 4/10 W at the frequencies of 2450/915 MHz for treating superficial tumors.
Pharmacokinetics and effect on renal function and average daily gain in lambs after castration and tail docking, of firocoxib and meloxicam

ABSTRACT Aims To evaluate and compare the pharmacokinetics of IM and oral firocoxib, and IM meloxicam, and detect their effect on renal function and average daily gain (ADG) in lambs undergoing tail docking and castration. Methods Seventy-five male Romney lambs, aged 3–6 weeks, were randomised into five treatment groups (n = 15 per group): IM firocoxib (1 mg/kg); oral firocoxib (1 mg/kg); IM meloxicam (1 mg/kg); normal saline (approximately 2 mL, oral); or sham. Following the treatment administration, hot-iron tail docking and rubber ring castration were performed in all groups except the sham group, which did not undergo the procedures, but the animals were handled in the same manner as castrated and tail docked lambs. Blood samples were collected before and 1, 2, 4, 6, 8, 24, 48, 72, 96 and 120 hours after treatment administration, and drug concentrations in plasma were quantified by liquid chromatography and mass spectrometry. Plasma urea and creatinine concentrations were determined at a commercial laboratory. Lamb body weights were recorded before and 2, 4 and 8 weeks after tail docking and castration. The pharmacokinetic analysis was carried out using a non-compartmental approach. Between-group and between-time-point differences were compared using mixed model analyses. Results There was no evidence for a difference in plasma elimination half-life between firocoxib given IM (LSM 18.6 (SE 1.4) hours), firocoxib given orally (LSM 18.2 (SE 1.4) hours), and meloxicam given IM (LSM 17. 0 (SE 1.4) hours). Firocoxib (IM) had a significantly greater volume of distribution (LSM 3.7 (SE 0.2) L/kg) than IM meloxicam (LSM 0.2 (SE 0.2) L/kg). Lambs in the meloxicam group had higher (p < 0.05) plasma urea and creatinine concentrations than those in the firocoxib, saline and sham groups. Lambs’ ADG was decreased (p < 0.01) compared to the other treatment groups in the 0–2 week period following meloxicam administration. Conclusions and clinical relevance Both formulations of firocoxib had a long plasma elimination half-life and large volume of distribution. There was a transient reduction in ADG in the meloxicam group, possibly due to mild renal toxicity. Comparative studies on dose–response effects of firocoxib and meloxicam in lambs following the procedures are required. Abbreviations: ADG: Average daily gain; Cmax: Maximum concentration; COX: Cyclooxygenase; LOD: Limit of detection; NSAID: Non-steroidal anti-inflammatory drugs; CL: Plasma clearance; T1/2el: Plasma elimination half-life; Tmax: Time to achieve Cmax; Vd: Volume of distribution
Advancements in understanding the role of microRnas in regulating macrophage polarization during acute lung injury

ABSTRACT Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is a critical and life-threatening illness that causes severe dyspnea, and respiratory distress and is often caused by a variety of direct or indirect factors that damage the alveolar epithelium and capillary endothelial cells, leading to inflammation factors and macrophage infiltration. Macrophages play a crucial role in the progression of ALI/ARDS, exhibiting different polarized forms at different stages of the disease that control the disease outcome. MicroRNAs (miRNA) are conserved, endogenous, short non-coding RNAs composed of 18–25 nucleotides that serve as potential markers for many diseases and are involved in various biological processes, including cell proliferation, apoptosis, and differentiation. In this review, we provide a brief overview of miRNA expression in ALI/ARDS and summarize recent research on the mechanism and pathways by which miRNAs respond to macrophage polarization, inflammation, and apoptosis. The characteristics of each pathway are also summarized to provide a comprehensive understanding of the role of miRNAs in regulating macrophage polarization during ALI/ARDS.
The baryon asymmetry

This is an in-depth look at baryon number violation in the Standard Model including the necessary background in finite temperature field theory, plasma dynamics and how to calculate the out of equilibrium evolution of particle number densities throughout a phase transition. It is a self-contained pedagogical review of the theoretical background to electroweak baryogenesis as well as a summary of the other prevailing mechanisms for producing the asymmetry between matter and antimatter using the Minimal Supersymmetric Standard Model as a pedagogical tool whenever appropriate.
Sex differences in fatigability and recovery following a 5 km running time trial in recreationally active adults

ABSTRACT Females demonstrate greater fatigue resistance compared to males in tasks ranging from single-limb contractions to whole-body exercise, including running. Many of the studies investigating sex differences in fatigability following running, however, occur after long duration, low-intensity tasks and it is unknown whether there is a sex difference in fatigability following high-intensity running. This study compared fatigability and recovery following a 5 km running time trial in young males and females. Sixteen recreationally active participants (8 males, 8 females, age: 23 ± 4 years) completed a familiarisation and experimental trial. Knee-extensor maximal voluntary contractions (MVCs) were performed before and up to 30 min after a 5 km time trial on a treadmill. Heart rate and rating of perceived exertion (RPE) were recorded after every kilometre during the time trial. Although not significantly different, males completed the 5 km time trial 15% faster than females (p = 0.095). Heart rate (p = 0.843) and RPE (p = 0.784) were similar between the sexes during the trial. Prior to running, males had larger MVCs (p = 0.014). The relative decrease in MVC force was less in females than males immediately post-exercise (−4.6 ± 2.4% vs. −15.1 ± 3.0%, p < 0.001) and at 10-minutes post-exercise (p = 0.018). At 20- and 30-minutes recovery, however, relative MVC force was not different between the sexes (p ≥ 0.129). These data demonstrate that females experienced less fatigability of the knee extensors than males following a high-intensity 5 km running time trial. The findings highlight the need to understand responses to exercise in both sexes and have implications for recovery from training and exercise prescription. Highlights Data regarding sex differences in fatigability following high-intensity running is relatively sparse. Therefore, this study quantified the decrease in knee-extensor maximum voluntary contraction force (MVC) following a 5-km self-paced running time trial. Despite similar heart rates and ratings of perceived exertion, the percentage decrease in MVC was three times greater in males compared to females. Relative MVCs remained greater in females compared to males until 20 min post-exercise.
Analgesic Efficacy of Combined Thoracic Paravertebral Block and Erector Spinae Plane Block for Video-Assisted Thoracic Surgery: A Prospective Randomized Clinical Trial

Background Thoracic paravertebral block (TPVB) and erector spinae plane block (ESPB) are widely used in video-assisted thoracic surgery (VATS). However, they have corresponding adverse effects, including hypotension for TPVB and unpredictable injectate spread in ESPB. An optimal perioperative analgesic strategy remains controversial. We investigated the effect of ultrasound-guided combined TPVB and ESPB (CTEB) for VATS. Material/Methods A total of 120 patients scheduled for thoracic surgery were randomized to receive either ultrasound-guided TPVB, ESPB, or CTEB preoperatively. Postoperative analgesia was achieved with sufentanil patient-controlled intravenous analgesia. The primary outcome was the static pain score at 2 h after surgery. Results The static pain score 2 h postoperatively was significantly different among the 3 groups. This difference was statistically significant for Group ESPB vs Group TPVB (P=0.004), but not for Group ESPB vs Group CTEB (P=0.767), or Group TPVB vs Group CTEB (P=0.117). Group TPVB exhibited the highest incidence of hypotension among the 3 groups. More patients experienced a sensory loss in Groups TPVB and CTEB 30 min after the block performance. Patients receiving CTEB exhibited a lower incidence of chronic pain 6 months postoperatively than those in Group ESPB. Conclusions CTEB does not enhance the analgesic effect of ESPB in patients undergoing VATS; however, it may induce a faster sensory loss after nerve block and reduce the incidence of postoperative chronic pain compared with ESPB. CTEB may also help to reduce the incidence of intraoperative hypotension compared with TPVB.
Tobacco/nicotine dependence as a risk factor for substance use disorders and related mental health conditions among cancer patients

Cancer patients often face multiple comorbidities and are at risk for various mental health conditions and substance use disorders. Tobacco/nicotine dependence (TND) is a known risk factor for poor health outcomes and has been associated with psychiatric disorders including substance use disorder. However, the specific relationship between TND and the risk of substance use disorder and mental health conditions among cancer patients remains underexplored. This study aimed to assess the association between TND and the risk of comorbid conditions among cancer patients.
Development of hybrid immunity during a period of high incidence of Omicron infections

Abstract Background Seroprevalence and the proportion of people with neutralizing activity (functional immunity) against SARS-CoV-2 variants were high in early 2022. In this prospective, population- based, multi-region cohort study, we assessed the development of functional and hybrid immunity (induced by vaccination and infection) in the general population during this period of high incidence of infections with Omicron variants. Methods We randomly selected and assessed individuals aged ≥16 years from the general population in southern (n = 739) and north-eastern (n = 964) Switzerland in March 2022. We assessed them again in June/July 2022, supplemented with a random sample from western (n = 850) Switzerland. We measured SARS-CoV-2 specific IgG antibodies and SARS-CoV-2 neutralizing antibodies against three variants (ancestral strain, Delta, Omicron). Results Seroprevalence remained stable from March 2022 (97.6%, n = 1894) to June/July 2022 (98.4%, n = 2553). In June/July, the percentage of individuals with neutralizing capacity against ancestral strain was 94.2%, against Delta 90.8% and against Omicron 84.9%, and 50.6% developed hybrid immunity. Individuals with hybrid immunity had highest median levels of anti-spike IgG antibodies titres [4518 World Health Organization units per millilitre (WHO U/mL)] compared with those with only vaccine- (4304 WHO U/mL) or infection- (269 WHO U/mL) induced immunity, and highest neutralization capacity against ancestral strain (hybrid: 99.8%, vaccinated: 98%, infected: 47.5%), Delta (hybrid: 99%, vaccinated: 92.2%, infected: 38.7%) and Omicron (hybrid: 96.4%, vaccinated: 79.5%, infected: 47.5%). Conclusions This first study on functional and hybrid immunity in the Swiss general population after Omicron waves showed that SARS-CoV-2 has become endemic. The high levels of antibodies and neutralization support the emerging recommendations of some countries where booster vaccinations are still strongly recommended for vulnerable persons but less so for the general population.
Adherence to HIV post-exposure prophylaxis in a specialized service in São Paulo, Brazil.

INTRODUCTION The effectiveness of human immunodeficiency virus (HIV) post-exposure prophylaxis (PEP) depends on adherence to the protocol, which includes taking antiretrovirals (ARVs) and attending visits. We examined the adherence rate to antiretroviral agents and follow-up visits identifying the associated characteristics of adherence and the reasons for not attending HIV PEP consultations in a specialized service in São Paulo, Brazil. METHODOLOGY This was a cross-sectional study with health service users who had an indication for PEP due to sexual exposure in an HIV/AIDS service from April to October 2019. The health service users were followed-up throughout the prophylaxis cycle. Adherence was determined through self-reports on antiretroviral agent use and attendance to follow-up consultations. RESULTS Association measures were employed to identify adherence-related characteristics. The sample analyzed included 91 users. The mean age was 32.5 years old (SD = 9.8). The largest share was white-skinned (49.5%), men who have sex with other men (62.2%), male (86.8%), and undergraduate/graduate students (65.9%). Adherence totaled 56.7% and health insurance was the associated characteristic (p = 0.039). Work (55.9%), using a private service (15.2%), forgetfulness (11.8%) and considering follow-up unnecessary (11.8%) were the main reasons for not attending the follow-up appointments. CONCLUSIONS Few users do attend HIV PEP consultations. The users without health insurance had the highest adherence percentage whereas work was mentioned as a reason for not attending HIV PEP consultations.