Miracle-dz/UniFAR-FTUs huggingface dataset:
Symptoms Compatible With Long Coronavirus Disease (COVID) in Healthcare Workers With and Without Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection—Results of a Prospective Multicenter Cohort

Background. The burden of long-term symptoms (ie, long COVID) in patients after mild COVID-19 is debated. Within a cohort of healthcare workers (HCWs), frequency and risk factors for symptoms compatible with long COVID are assessed. Methods. Participants answered baseline (August/September 2020) and weekly questionnaires on SARS-CoV-2 nasopharyngeal swab (NPS) results and acute disease symptoms. In January 2021, SARS-CoV-2 serology was performed; in March, symptoms compatible with long COVID (including psychometric scores) were asked and compared between HCWs with positive NPS, seropositive HCWs without positive NPS (presumable asymptomatic/pauci-symptomatic infections), and negative controls. The effect of time since diagnosis and quantitative anti-spike protein antibodies (anti-S) was evaluated. Poisson regression was used to identify risk factors for symptom occurrence. Results. Of 3334 HCWs (median, 41 years; 80% female), 556 (17%) had a positive NPS and 228 (7%) were only seropositive. HCWs with positive NPS more frequently reported ≥ 1 symptom compared with controls (73% vs 52%, P < .001); seropositive HCWs without positive NPS did not score higher than controls (58% vs 52%, P = .13), although impaired taste/olfaction (16% vs 6%, P < .001) and hair loss (17% vs 10%, P = .004) were more common. Exhaustion/burnout was reported by 24% of negative controls. Many symptoms remained elevated in those diagnosed >6 months ago; anti-S titers correlated with high symptom scores. Acute viral symptoms in weekly questionnaires best predicted long-COVID symptoms. Physical activity at baseline was negatively associated with neurocognitive impairment and fatigue scores. Conclusions. Seropositive HCWs without positive NPS are only mildly affected by long COVID. Exhaustion/burnout is common, even in noninfected HCWs. Physical activity might be protective against neurocognitive impairment/fatigue symptoms after COVID-19.
Reconstructing the Late Cretaceous inversion of the Roer Valley Graben (southern Netherlands) using a new model that integrates burial and provenance history with fission track thermochronology

[1] Apatite fission track thermochronology is a powerful tool for the reconstruction of the thermal and geological evolution of sedimentary basins. However, reconstructing basin evolution using thermochronological data is complicated by the fact that sediments also record the thermal history of their source areas. Moreover, samples frequently contain grains from multiple source areas. We have constructed a new numerical model that integrates sediment burial and thermal history with provenance history scenarios and that uses the derived thermal history to calculate synthetic apatite fission track data. We have applied this model to study the evolution of the Roer Valley Graben and to explore the dependency of fission track data on provenance and basin thermal history. Samples that are buried at shallow depths (<1400 m) preserve a mix of late Paleozoic and early Mesozoic provenance ages that correspond to the Caledonian and Variscan orogenic events of the sediment source areas, the London-Brabant and Ardenno-Rhenish massifs, respectively, with varying degrees of subsequent exhumation. Using this knowledge about the inherited thermal history, fission track data of Mesozoic sediments could be used to constrain the Late Cretaceous inversion of the basin with an accuracy of ±250 to ±500 m. These results show that inversion-related exhumation was localized, reaching a maximum of 750 to 1250 m in the eastern part of the basin, while not exceeding 500 m in the western half of the basin. These results are in agreement with the distribution of preserved preinversion sediments and syninversion sediment accumulations that flank the northeastern part of the basin.
Comment on “A new estimate for present‐day Cocos‐Caribbean plate motion: Implications for slip along the Central American volcanic arc” by Charles DeMets

We comment on “A new estimate for present‐day Cocos‐Caribbean plate motion: Implications for slip along the Central American volcanic arc” by Charles DeMets. We find the following inconsistencies in his model: Components of relative motion along the arc are small and variable, not uniform. There is no single surface faulting and earthquakes occur on faults along and perpendicular to the arc. Earthquakes also stop in the middle of the arc. Geometrically, the model calls for buttressing, but there is no evidence for this.
Differential Effects of Chronic Immunosuppression on Behavioral, Epigenetic and Alzheimer’s Disease- Associated Markers in 3xTg-AD Mice

Minesh Kapadia McMaster University Firoz M. Mian McMaster University Donglai Ma McMaster University Craig P. Hutton McMaster University Amber Azam University of Toronto Mississauga Klotilda Narkaj University of Toronto Mississauga Chuanhai Cao University of South Florida Breanna Brown University of South Florida Bernadeta Michalski McMaster University David Morgan Michigan State University Paul Forsythe McMaster University Iva B. Zovkic University of Toronto Mississauga Margaret Fahnestock McMaster University Boris Sakic (  sakic@mcmaster.ca ) McMaster University Faculty of Health Sciences https://orcid.org/0000-0002-0531-4872
Deciphering isotopic signals of monsoon-induced upwelling in foraminifera from the Western Arabian sea sediment trap

Isotopic analyses have been made on four species of foraminifera collected with a PARFLUX Mark VI sediment trap in the Arabian Sea during the 1986 and 1987 monsoons. Two of the species are non-spinose thermocline dwellers (Neogloboquadrina dutertrei, Globorotalia menardii) and two are spinose surface dwellers (Globigerinoides sacculifer, Globigerina bulloides). Individual tests were measured for shape, and analyzed for carbon and oxygen isotopes to document how each species responded to phases of the upwelling system, and to determine the utility of these planktonic foraminifera as upwelling indicators. The oxygen isotopic composition of the two thermocline dwellers remained fairly constant during the seasonal monsoon cycle, showing little to no effect from upwelling whereas the surface dwellers exhibited a wider range of 6180 values. The 813C signal shows a similar pattern, with the thermocline dwellers showing less variation than the surface dwellers. Results are compared to the empirical model of Kroon and Ganssen (1989) that describes a faunal succession of planktonic foraminiferal species based on isotopic composition and timing of optimum growth conditions. The succession of species based on fluxes was inconclusive and although three of the species showed the same isotopic patterns as described in the model, G. bulloides was not enriched in 813C, as predicted. The covariance of 813C and 6180 in this particular species suggests that G. bulloides is isotopically unreliable for reconstruction of monsoon-induced upwelling in the Arabian Sea. Thesis Supervisor: Dr. William B. Curry Title: Senior Scientist, Geology and Geophysics Department Chair
Low‐P–high‐T metamorphism and the role of heat transport by melt migration in the Higo Metamorphic Complex, Kyushu, Japan

This paper characterizes the metamorphic thermal structure of the Higo Metamorphic Complex (HMC) and presents the results of a numerical simulation of a geotherm with melt migration and solidification. Reconstruction of the geological and metamorphic structure shows that the HMC initially had a simple thermal structure where metamorphic temperatures and pressures increased towards apparent lower structural levels. Subsequently, this initial thermal structure has been collapsed by E–W and NNE–SSW trending high‐angle faults. Pressure and temperature conditions using the analysis of mineral assemblages and thermobarometry define a metamorphic field P–T array that may be divided into two segments: the array at apparent higher structural levels has a low‐dP/dT slope, whereas that at apparent lower structural levels has a high‐dP/dT slope. This composite array cannot be explained by heat conduction in subsolidus rocks alone. Migmatite is exposed pervasively at apparent lower structural levels, but large syn‐metamorphic plutons are absent at the levels exposed in the HMC. Transport and solidification of melt within migmatite is a potential mechanism to generate the composite array. Thermal modelling of a geotherm with melt migration and solidification shows that the composite thermal structure may be formed by a change of the dominant heat transfer from an advective regime to a conduction regime with decreasing depth. The model also predicts that strata beneath the crossing point will consist of high‐grade solid metamorphic rocks and solidified melt products, such as migmatite. This prediction is consistent with the observation that migmatite was associated with the very high‐dP/dT slope. The melt migration model is able to generate the very high‐dP/dT segment due to the high rate of heat transfer by advection.
Ubiquity of Biological Ice Nucleators in Snowfall

Despite the integral role of ice nucleators (IN) in atmospheric processes leading to precipitation, their sources and distributions have not been well established. We examined IN in snowfall from mid- and high-latitude locations and found that the most active were biological in origin. Of the IN larger than 0.2 micrometer that were active at temperatures warmer than -7�C, 69 to 100% were biological, and a substantial fraction were bacteria. Our results indicate that the biosphere is a source of highly active IN and suggest that these biological particles may affect the precipitation cycle and/or their own precipitation during atmospheric transport.
Genomewide association study of a rapid progression cohort identifies new susceptibility alleles for AIDS (ANRS Genomewide Association Study 03).

BACKGROUND Previous genomewide association studies (GWASs) of AIDS have targeted end points based on the control of viral load and disease nonprogression. The discovery of genetic factors that predispose individuals to rapid progression to AIDS should also reveal new insights into the molecular etiology of the pathology. METHODS We undertook a case-control GWAS of a unique cohort of 85 human immunodeficiency virus type 1 (HIV-1)-infected patients who experienced rapid disease progression, using Illumina HumanHap300 BeadChips. The case group was compared with a control group of 1352 individuals for the 291,119 autosomal single-nucleotide polymorphisms (SNPs) passing the quality control tests, using the false-discovery rate (FDR) statistical method for multitest correction. RESULTS Novel associations with rapid progression (FDR, < or = 25%) were identified for PRMT6 (P = 6.1 x 10(-7); odds ratio [OR], 0.24), SOX5 (P = 1.8 x 10(-6); OR, 0.45), RXRG (P = 3.9 x 10(-6); OR, 3.29), and TGFBRAP1 (P = 7 x 10(-6); OR, 0.34). The haplotype analysis identified exonic and promoter SNPs potentially important for PRMT6 and TGFBRAP1 function. CONCLUSIONS The statistical and biological relevance of these associations and their high ORs underscore the power of extreme phenotypes for GWASs, even with a modest sample size. These genetic results emphasize the role of the transforming growth factor beta pathway in the pathogenesis of HIV-1 disease. Finally, the wealth of information provided by this study should help unravel new diagnostic and therapeutic targets.
How Scary! An analysis of visual communication concerning genetically modified organisms in Italy

Several studies evidence the role of media in influencing public perception towards genetically modified organisms, while visual communication has been scarcely investigated. This paper aims at evaluating the exposure of Italian population to scary GMO-related images. A set of 517 images collected through Google are classified considering fearful attributes and an index that accounts for the scary impact (SI) of these images is built. Then through an ordered logistic regression we estimate the relationship between the SIIndex and a set of variables that describes the context in which images appear. Results reveal that the first (and most viewed) Google result images contain the most frightful contents. In addition, agri-food sector in Italy is strongly oriented in offering a negative representation of genetically modified organisms. Exposure to scary images could be a factor that affects the negative perception of GMOs in Italy.
Dealing with Missing Data

When faced with missing data, many investigators will simply analyze only those cases with complete data – also known as listwise deletion or complete case analysis. However, there are many problems with this approach. The sample size may shrink dramatically which may preclude performing some types of statistical analyses. There is a loss of statistical power to detect treatment effects or predictors of outcome. In addition, the results obtained may be quite inaccurate or biased. In some cases, entire research projects can be jeopardized by missing data when complete case analysis is used.
Déformation et mise en place des granites (360-300Ma) dans un segment de la Chaîne Varisque (Plateau de Millevaches, Massif Central)

Le Limousin (NW du Massif Central) est caracterise par de larges massifs granitiques mis en place entre 360 et 290 Ma. Ils presentent d'etroites relations spatiales avec de grands accidents ductiles en faille normale et decrochement qui prolongent vers le SE la zone de cisaillement Sud Armoricaine. Le volumineux (~ 10000km3) complexe granitique N-S de Millevaches, limite par des decrochements et failles normales, est un exemple type de granite mis en place dans un contexte tectonique decrochant. Le modele de mise en place des granites de Millevaches prend en compte l'analyse structurale, microstructurale, magnetique (A.S.M.), gravimetrique et geochronologique (40Ar/39Ar et U/Pb). L'ascension des magmas se fait par des conduits verticaux etroits sous forme d'injections successives qui se relaient le long de l'axe principal N-S des Pradines. Les magmas sont ensuite pieges puis canalises par la foliation precoce, anisotropie mecanique sub-horizontale majeure de la croute moyenne. Les magmas syntectoniques du decrochement dextre N-S des Pradines enregistrent des trajectoires de deformation orientees N-S dans la faille et NW-SE de part et d'autre. La poussee du magma au toit du laccolite induit une deformation par aplatissement relaxee par le developpement de failles d'echappement sub-horizontales et normales. La mise en place syntectonique des leucogranites du Millevaches, datee a 313 ± 4 Ma est contemporaine du metamorphisme granulitique subi par les roches encaissantes. Le fonctionnement des decrochements du Limousin debute vers 350 Ma et finit vers 300 Ma. Nous proposons que les deux generations de granites (granodiorite-monzogranite et leucogranite) se mettent en place des 350 Ma, dans une ceinture tectonique resultant d'un contexte en transpression. Les cisaillements ductiles constituent les branches d'un large, long (~700 km), et unique systeme decrochant lithospherique analogue a une « pop-up structure » NW-SE dextre allant du Massif Sud Armoricain au Limousin.
The impact of global warming on river runoff

River runoff from the world's major rivers is an important part of the hydrologic cycle. Runoff changes in response to global greenhouse-induced warming will have impacts in many areas, including agriculture, water resources, and land use. A global atmospheric model is used to calculate the annual river runoff for 33 of the world's major rivers for the present climate and for a doubled CO2 climate. The model has a horizontal resolution of 4° × 5°, but the runoff from each model grid box is quartered and added to the appropriate river drainage basin on a 2° × 2.5° resolution. The computed runoff depends on the model's precipitation, evapotranspiration, and soil moisture storage. For the doubled CO2 climate, the runoff increased for 25 of the 33 rivers, and in most cases the increases coincided with increased rainfall within the drainage basins. There were runoff increases in all rivers in high northern latitudes, with a maximum increase of 47%. At low latitudes there were both increases and decreases ranging from a 96% increase to a 43% decrease. The effect of the simplified model assumptions of land-atmosphere interactions on the results is discussed.
Between-task competition for intentions and actions

People can switch quickly and flexibly from one task to another, but suffer the effects of between-task competition when they do so: After switching, they tend to be distracted by irrelevant stimulus information and hampered by incorrect actions associated with recently performed tasks. This competition results in performance costs of switching, as well as a bias against switching when there is choice over which task to perform, particularly when switching from a difficult task to an easier one. Two experiments investigated the locus of these between-task competition effects in voluntary task switching. Participants switched between an easy location classification and a harder shape classification, making two responses on each trial: the first to register their task choice, the second to perform the chosen task on a subsequently presented stimulus. The results indicated that participants chose to perform the difficult shape task more often than the easier location task, evidence that between-task competition affects intentions that are expressed independently of task-specific actions. The bias was stronger in participants with faster choice speed, suggesting that these influences are relatively automatic. Moreover, even though participants had unlimited time to choose and prepare a task before stimulus presentation, their subsequent performance was nonetheless sensitive to persisting effects of between-task competition. Altogether these results indicate the pervasive influence of between-task competition, which affects both the expression of global task intentions and the production of task-specific actions.
Effects of fluid-shear resistance and squirt flow on velocity dispersion in rocks

ABSTRACTLaboratory measurements of rocks saturated with high-viscosity fluids (such as heavy-oil, bitumen, magma, kerogen, etc.) often exhibit considerable seismic velocity dispersion, which is usually underestimated by the Biot theory. Over the years, grain-scale dispersion mechanisms such as squirt (local-flow) and shear relaxation (nonzero shear stress in the pore fluid) have been more successful in explaining the measured dispersion. We developed a new method to quantify the combined high-frequency effects of squirt and shear dispersion on the effective moduli of rocks saturated with viscous fluids. Viscous fluid at high frequencies was idealized as an elastic solid of finite shear modulus, hydraulically locked in stiff and soft pores. This method entailed performing solid substitution in stiff pores of a dry rock frame, which itself was unrelaxed due to solid-filled soft pores. The unrelaxed frame stiffness solutions required information on the pressure dependency of the rock stiffness and porosity.
Smartphone-delivered multicomponent lifestyle medicine intervention for depressive symptoms: A randomized controlled trial.

OBJECTIVE To evaluate the efficacy and credibility of a smartphone-delivered multicomponent lifestyle medicine (LM) intervention, Lifestyle Hub, as a primary modality for managing depressive symptoms in an adult Chinese population. METHOD Participants with at least a moderate level of depressive symptoms (n = 79), as indicated by a Patient Health Questionnaire-9 score of ≥10, were randomly assigned to an LM intervention group (LMG; n = 39; eight weekly sessions) or a waitlist control group (WLG; n = 40). RESULTS The intention-to-treat analysis revealed significant improvements in depressive symptoms (d = 0.66), generalized anxiety symptoms (d = 0.93), insomnia symptoms (d = 0.20), functional impairment (d = 0.22), and health-related quality of life (HRQoL; d = 0.11) from Week 0 (baseline) to Week 9 (immediate post-intervention assessment) in the LMG relative to the WLG. Moreover, significantly more health-promoting behaviors (overall health behaviors, health responsibility, physical activity level, nutrition, spiritual growth, and stress management) (d = 0.40-0.89) and higher levels of total activity (d = 0.55) and walking activity (d = 0.55) were found at Week 9 in the LMG relative to the WLG. However, no significant differences were observed in interpersonal relationships, vigorous and moderate exercise levels, sedentary behavior levels, or food frequency questionnaire measures at Week 9 between the LMG and the WLG. From Week 9 to Week 13 (1-month follow-up assessment), a significant within-group reduction in HRQoL (d = 0.50) and an increase in alcohol intake (d = 0.41) were observed in the LMG. CONCLUSIONS The smartphone-delivered multicomponent LM intervention Lifestyle Hub may serve as a primary modality for managing depressive symptoms. (PsycInfo Database Record (c) 2022 APA, all rights reserved).
Chemical Editing of Proteoglycan Architecture

Proteoglycans are heterogeneous macromolecular glycoconjugates that orchestrate many important cellular processes. While much attention has focused on the poly-sulfated glycosaminoglycan chains that decorate proteoglycans, other important elements of proteoglycan architecture, such as their core proteins and cell surface localization, have garnered less emphasis. Hence, comprehensive structure-function relationships that consider the replete proteoglycan architecture as glycoconjugates are limited. Here, we present a comprehensive approach to study proteoglycan structure and biology by fabricating defined semi-synthetic modular proteoglycans that can be tailored for cell surface display. To do so, we integrate amber codon reassignment in the expression of sequence-fined proteoglycan core proteins, metabolic oligosaccharide engineering to produce functionalizable glycosaminoglycans, and bioorthogonal click chemistry to covalently tether the two components. These materials permit the methodical dissection of the parameters required for optimal binding and function of various proteoglycan-binding proteins, and they can be modularly displayed on the surface of any living cell. We demonstrate that these sophisticated materials can recapitulate the functions of native proteoglycans in mouse embryonic stem cell differentiation and cancer cell spreading, while permitting the identification of the most important contributing elements of proteoglycan architecture toward function. This technology platform will confer structural resolution toward the investigation of proteoglycan structure-function relationships in cell biology.