Miracle-dz/UniFAR-FTUs huggingface dataset:
Long-Term Effects of Single-Dose Cephalosporin or Macrolide Use on the Prevalence of AmpC and Extended-Spectrum β-Lactamase Producing Escherichia coli in the Feces of Beef Cattle

Extended-spectrum-β-lactamase (ESBL) and AmpC-lactamase-producing Enterobacteriaceae are serious public health threats. Due to an increasing number of reports of ESBL and AmpC producing Escherichia coli in agricultural settings, it is critical to understand the relationship between the use of two of the highest priority critically important human antibiotics (e.g., third generation cephalosporins [3GC] and macrolides) in food animals and their potential contribution to the selection of ESBL/AmpC E. coli. The objective of our randomized controlled feedlot trial was to measure the effects of ceftiofur crystalline-free acid and tulathromycin on 3GC resistant fecal E. coli populations in cattle before and at various time points after treatment up to and including at slaughter. Multi-level mixed-effects linear regression showed no effect of ceftiofur and tulathromycin on 3GC E. coli CFU counts at slaughter (Day 99); however, a significant (p < 0.05) population shift was observed from susceptible to 3GC resistant E. coli immediately after ceftiofur administration (Day 7). Among 799 fecal samples screened using selective media, 17.7% were ESBL/AmpC E. coli positive, which were further tested for phenotypic antibiotic susceptibility. The majority of the isolates from these plates were multidrug-resistant (94.3%) and expressed either AmpC (78.1%) or ESBL (28.1%) phenotype. A subset of isolates was whole-genome sequenced (n = 20) and identified to harbor chromosomal and/or plasmidal bla genes such as CMY-2, CTX-M, and TEM. Our findings show a time-dependent selection of antibiotics on 3GC-resistant E. coli. High prevalence of multidrug-resistant ESBL/AmpC E. coli found in cattle feces highlights the importance of prudent use of antibiotics in livestock.
Regulation of Molecular Targets in Osteosarcoma Treatment

The most prevalent malignant bone tumor, osteosarcoma, affects the growth plates of long bones in adolescents and young adults. Standard chemotherapeutic methods showed poor response rates in patients with recurrent and metastatic phases. Therefore, it is critical to develop novel and efficient targeted therapies to address relapse cases. In this regard, RNA interference technologies are encouraging options in cancer treatment, in which small interfering RNAs regulate the gene expression following RNA interference pathways. The determination of target tissue is as important as the selection of tissue-specific promoters. Moreover, small interfering RNAs should be delivered effectively into the cytoplasm. Lentiviral vectors could encapsulate and deliver the desired gene into the cell and integrate it into the genome, providing long-term regulation of targeted genes. Silencing overexpressed genes promote the tumor cells to lose invasiveness, prevents their proliferation, and triggers their apoptosis. The uniqueness of cancer cells among patients requires novel therapeutic methods that treat patients based on their unique mutations. Several studies showed the effectiveness of different approaches such as microRNA, drug- or chemotherapy-related methods in treating the disease; however, identifying various targets was challenging to understanding disease progression. In this regard, the patient-specific abnormal gene might be targeted using genomics and molecular advancements such as RNA interference approaches. Here, we review potential therapeutic targets for the RNA interference approach, which is applicable as a therapeutic option for osteosarcoma patients, and we point out how the small interfering RNA method becomes a promising approach for the unmet challenge.
Imaging of the umbrella motion and tunneling in ammonia molecules by strong-field ionization

The geometry-dependent ionization behavior of the ammonia molecule is investigated. Different theoretical approaches for obtaining the ionization yield are compared, all of them showing a strong dependence of the ionization yield on the inversion coordinate at long wavelengths ($\geq$ 800 nm). It is shown how this effect can be exploited to create and probe nuclear wave packets in neutral ammonia using Lochfras. Furthermore, imaging of a wave packet tunneling through the barrier of a double-well potential in real time is discussed.
[177Lu]Lu-PSMA-617 (PluvictoTM): The First FDA-Approved Radiotherapeutical for Treatment of Prostate Cancer

In March 2022, [177Lu]Lu-PSMA-617 (PluvictoTM) was approved by the FDA for the treatment of prostate cancer patients. Until now, the approval has been limited to patients with PSMA-positive metastatic castration-resistant prostate cancer who have previously received other therapy options (such as inhibition of the androgen receptor pathway and taxane-based chemotherapy). [177Lu]Lu-PSMA-617, which combines a PSMA-specific peptidomimetic with a therapeutical radionuclide, is used in a radioligand therapy that selectively delivers ionizing radiation to tumor cells, causing their death, while sparing the surrounding healthy tissue. In numerous clinical trials, the efficacy of [177Lu]Lu-PSMA-617 was demonstrated.
Experiential festival attributes, perceived value, cultural exploration, and behavioral intentions to visit a food festival

Abstract Based on the expectation confirmation theory and the push and pull framework, this paper proposes that perceived value (PV) mediates the relationship between experiential food festival attributes (EXPECO) and attendees’ behavioral intentions (BIs). Further, this paper proposes that cultural exploration (CULEXP) moderates the causal relationships among EXPECO, PV, and BIs. A survey of 215 visitors who participated in the Slow Food Festival event in Northern Cyprus was used to statistically validate the proposed research framework and hypotheses. The results stemmed from the structural equation modeling show that PV partially mediated the effects of EXPECO (i.e., education, entertainment, and esthetic experience) on BIs. Moreover, as predicted, the results confirm that CULEXP moderates the casual relationships among EXPECO, PV, and BIs. Thus, the findings extend prior literature by highlighting the importance of EXPECO and CULEXP in enhancing attendees’ PV and consequent positive BIs.
Sense of belonging during a global pandemic: a case of accounting students

ABSTRACT In this paper, we use the context of a global pandemic and subsequent movement between on-campus and online teaching to explore the concept of students’ sense of belonging. We ask how the sense of belonging in accounting students has been impacted during the pandemic and what are the lessons learned from such observations. Considering teaching and learning at University A (The University’s name is blind as per the review requirement of the journal), New Zealand as a case study, and the COVID-19 pandemic as a natural experiment, we explore a sense of belonging in our accounting students. We speculate that whether the new circumstances be beneficial or detrimental to students’ sense of belonging would depend on many factors. Our study offers practical implications for accounting educators and the higher education sector to enhance students’ sense of belonging when facing disruption.
Tolerance, Adaptation, and Cell Response Elicited by Micromonospora sp. Facing Tellurite Toxicity: A Biological and Physical-Chemical Characterization

The intense use of tellurium (Te) in industrial applications, along with the improper disposal of Te-derivatives, is causing their accumulation in the environment, where oxyanion tellurite (TeO32−) is the most soluble, bioavailable, and toxic Te-species. On the other hand, tellurium is a rare metalloid element whose natural supply will end shortly with possible economic and technological effects. Thus, Te-containing waste represents the source from which Te should be recycled and recovered. Among the explored strategies, the microbial TeO32− biotransformation into less toxic Te-species is the most appropriate concerning the circular economy. Actinomycetes are ideal candidates in environmental biotechnology. However, their exploration in TeO32− biotransformation is scarce due to limited knowledge regarding oxyanion microbial processing. Here, this gap was filled by investigating the cell tolerance, adaptation, and response to TeO32− of a Micromonospora strain isolated from a metal(loid)-rich environment. To this aim, an integrated biological, physical-chemical, and statistical approach combining physiological and biochemical assays with confocal or scanning electron (SEM) microscopy and Fourier-transform infrared spectroscopy in attenuated total reflectance mode (ATR-FTIR) was designed. Micromonospora cells exposed to TeO32− under different physiological states revealed a series of striking cell responses, such as cell morphology changes, extracellular polymeric substance production, cell membrane damages and modifications, oxidative stress burst, protein aggregation and phosphorylation, and superoxide dismutase induction. These results highlight this Micromonospora strain as an asset for biotechnological purposes.
Sexual knowledge based on Islamic values and sexual risk behaviors of HIV/STIs among Thai Muslim army conscripts: A cross-sectional study

Background Sexually transmitted infections (STIs), including human immunodeficiency virus (HIV), are commonly associated with conflict areas. In Thailand, conflict situations have occurred from 2004 until the present in three Muslim-majority southernmost provinces, including Yala, Pattani, and Narathiwat. However, Islam provides strict guidelines on sexuality. Therefore, those who strictly practice Islam will have lower sexual risk behavior. Objective This study aimed to examine the relationship between Islamic values-based sexual knowledge, sociodemographic factors, and risk for HIV/STIs among Thai Muslim army conscripts in the unrest situation area. Methods A cross-sectional study was conducted between May and July 2020. Data were collected using a validated questionnaire among 421 participants. Descriptive statistics and Chi-square were used to examine the association among variables. Results 57.5% of Muslim army conscripts had poor sexual knowledge based on Islamic aspects, and the participants showed high-risk profiles for HIV/STIs (32.5%). Marital status, hometown, smoking and drinking status, and Islamic values-based sexual knowledge were significantly associated with the risk of HIV/STIs (p <0.05). Conclusion Participants with poor sexual knowledge according to Islamic values, smokers, single-status, alcoholic drinkers, and non-three southernmost provinces’ hometowns had higher risks of HIV/STIs. Thus, it is suggested that nurses and public health professionals implement sexual health promotion and prevention for HIV/STIs. In addition, misperceptions of Islamic aspects toward sexual behavior should receive immediate adjustments.
The matrix product solution of the multispecies partially asymmetric exclusion process

We find the exact solution for the stationary state measure of the partially asymmetric exclusion process on a ring with multiple species of particles. The solution is in the form of a matrix product representation where the matrices for a system of N species are defined recursively in terms of the matrices for a system of N − 1 species. A complete proof is given, based on the quadratic relations verified by these matrices. This matrix product construction is interpreted in terms of the action of a transfer matrix.
Escaping from the black hole

We show that if there exists a special kind of Born-Infeld type scalar field, then one can send information from inside a black hole. This information is encoded in perturbations of the field propagating in non-trivial scalar field backgrounds, which serves as a new ether. Although the theory is Lorentz-invariant it allows, nevertheless, the superluminal propagation of perturbations with respect to the new ether. We found the stationary solution for background, which describes the accretion of the scalar field onto a black hole. Examining the propagation of small perturbations around this solution we show the signals emitted inside the horizon can reach an observer located outside the black hole. We discuss possible physical consequences of this result.
Ikhnos: A Novel Software to Register and Analyze Bone Surface Modifications Based on Three-Dimensional Documentation

Simple Summary Here we present a novel open-access 3D software called Ikhnos to register and analyze bone surface modifications in bone assemblages using a sample of wild and captive wolf populations as an example to demonstrate the possibilities offered by this newly developed toolkit. The study of bone surface modifications has been proven crucial in understanding archaeological and paleontological site formation processes, including the identification of the assemblage causal agent. The use of the tools provided by Ikhnos will help interpret the fossil record by allowing the generation of accurate biological and physicochemical referential models as well as the precise documentation of bone surface modifications in archaeological and paleontological assemblages. Abstract The study of bone surface modifications (BSM) is crucial in understanding site formation processes and the identification of the causal agent behind bone assemblages in the fossil record. In that line, many efforts have been made to generate referential models based on feeding experiments and human butchery simulations that can then be used to interpret the patterns observed in archaeological and paleontological sites. Considering these needs, we developed a novel open-access three-dimensional (3D) software called Ikhnos for the study of BSM distribution patterns on limb long bones. This software is comprised of all the necessary tools for the 3D documentation of BSM and bone breakage patterns, as well as the subsequent statistical analysis of this data due to the integration of an exclusive R library, the IkhnosToolBox. Additionally, Ikhnos integrates tools for bone survivorship calculations that could facilitate the estimation of the minimum number of elements (MNE) and minimum number of individuals (MNI). As a demonstration of its precision, here we present a case study analyzing the modifications produced by wild and captive wolf (Canis lupus signatus) populations of the Iberian Peninsula on deer carcasses.
An Empirical Investigation of University Students’ Behavioural Intention to Adopt Online Learning: Evidence from China

The present study examined the relationship among behavioural intention (BI) to adopt online learning, perceived usefulness (PU), perceived ease of use (PEU), self-regulated online learning (SR) and online learning self-efficacy (SE). A total of 900 university students with online learning experience from many provinces of China took part in the study. Structural equation modelling (SEM) was used to analyse the data accepted. The results indicate that PU has a significant positive effect on BI; SR has a significant positive effect on PEU, PU and BI. SE has a significant positive effect on PEU, PU and BI. In addition, SE and SR have significant indirect effects on BI through the mediation of PU. The outcomes have tangible theoretical and practical implications. They not only replicates previous research and provides possible space for further expansion of TAM, but also provide us with an opportunity to reflect on and actively take practical measures to improve BI. These efforts include teachers, parents and other educators trying to promote students’ academic achievements, self-efficacy and self-regulation in the process of online learning. The former is the most concerning issue, while the latter two are the source of students’ motivation. Furthermore, educators should make appropriate use of the role of digital technology in online learning and be careful not to exaggerate the value of digital technology, let alone equate it with online learning.
Predicting Switching Intention Among Generation Y Using DeLone & McLean (Study on Shopee App)

The objective of this study is to look at the impact of systemquality, information quality, and service quality on satisfaction and switchingintention among Generation Y Shopee users. Data analyzed using PartialLeast Square. The result shows that system quality, information quality, andservice quality significantly has a positive impact on satisfaction. At thatpoint satifaction was moreover found to have a negative impact on intentionto switch. Service quality was found to have a more prominent impact. Thisimplies that Shopee needs to focus on improving service quality, since serviceis considered to have an important part in determining user satisfaction.
Detrimental Effects of Lipid Peroxidation in Type 2 Diabetes: Exploring the Neutralizing Influence of Antioxidants

Lipid peroxidation, including its prominent byproducts such as malondialdehyde (MDA) and 4-hydroxy-2-nonenal (4-HNE), has long been linked with worsened metabolic health in patients with type 2 diabetes (T2D). In fact, patients with T2D already display increased levels of lipids in circulation, including low-density lipoprotein-cholesterol and triglycerides, which are easily attacked by reactive oxygen molecules to give rise to lipid peroxidation. This process severely depletes intracellular antioxidants to cause excess generation of oxidative stress. This consequence mainly drives poor glycemic control and metabolic complications that are implicated in the development of cardiovascular disease. The current review explores the pathological relevance of elevated lipid peroxidation products in T2D, especially highlighting their potential role as biomarkers and therapeutic targets in disease severity. In addition, we briefly explain the implication of some prominent antioxidant enzymes/factors involved in the blockade of lipid peroxidation, including termination reactions that involve the effect of antioxidants, such as catalase, coenzyme Q10, glutathione peroxidase, and superoxide dismutase, as well as vitamins C and E.
Honey-Propolis-Engineered Collagen Peptides as Promising Wound-Healing Matrix in Mouse Model

In this study, collagen hydrolysates (CHDs) were fabricated with honey-propolis wax (HPW), structurally modified as a sponge matrix, and experimentalized on wound healing in a mouse model. The scaffold was characterized by means of in vitro enzymatic degradation; in vitro HPW release; and in vivo wound-healing mouse model, wound-healing-specific RNA, transcripts, and protein markers. The functional activity of the HPW extracted from raw propolis was determined using total flavonoids, antioxidant scavenging assays, and anti-hemolytic principles. The results indicated that HPW had a high flavonoid content (20 μg/mL of wax) and antioxidant activities. The effective concentration (EC50) of HPW was estimated (28 mg/mL) and was then used in the subsequent in vivo experiments. Additionally, the dopped mixture of CHDs and HPW substantially enhanced the wound-healing process and regulated wound biochemical markers such as hexoseamine and melondialdehyde. CHDs- HPW upregulated the expression of growth factors including vascular endothelial growth factor (VEGF) (2.3-fold), fibroblast growth factor (FGF) and epidermal growth factor (EGF) (1.7-fold), and transforming growth factor-beta (TGF-β) (3.1-fold), indicating their potential capacity to perform wound re-epithelialization and the loading of ground tissue. Pro-inflammatory markers IL-1 β (51 pg/mL) and TNF-α (220 pg/mL) were significantly reduced in the CHD-HPW-treated wound. These interesting results were further confirmed using mRNA and protein growth factors from the wound, which enhanced the load of collagen-I in the wound site. In conclusion, CHDs-HPW exhibited a significant reduction in inflammation and inflammatory markers and helped to obtain a faster wound-healing process in a mouse model. The newly engineered biosponge could be developed as a promising therapeutic approach for the regeneration and repair of damaged human skin in the future.
The puzzle of energy efficiency in Turkey: combining a multiple criteria decision making and the time series analysis

ABSTRACT Enhancing energy efficiency is important for sustainable economic development and environmental-related issues such as carbon emissions. Therefore, measuring energy efficiency is crucial for countries to achieve economic and environmental objectives. In this study, we utilize the TOPSIS method with the intent of monitoring the energy efficiency of Turkey from the 1980 to 2018 period. Several variables such as renewable and nonrenewable energy consumption, GDP, labor force, and capital stock are employed in calculating energy efficiency scores. Thereafter, we analyze the long-term, symmetric and asymmetric effects of some contextual variables such as capital stock-labor force ratio, renewable energy consumption-total energy consumption ratio, and carbon emission-total energy consumption ratio on energy efficiency via ARDL and nonlinear ARDL models. Results from the linear model indicate that an increase in the renewable energy consumption-total energy consumption ratio and capital stock-labor force ratio increase the energy efficiency. In contrast, an increase in the carbon emission-total energy consumption ratio decreases it. The nonlinear ARDL model, on the other hand, signals asymmetric effects in the long-run but not in the short-run.
The Structural Interactions of Molecular and Fibrillar Collagen Type I with Fibronectin and Its Role in the Regulation of Mesenchymal Stem Cell Morphology and Functional Activity

The observed differences in the structure of native tissue and tissue formed in vitro cause the loss of functional activity of cells cultured in vitro. The lack of fundamental knowledge about the protein mechanism interactions limits the ability to effectively create in vitro native tissue. Collagen is able to spontaneously assemble into fibrils in vitro, but in vivo, other proteins, for example fibronectin, have a noticeable effect on this process. The molecular or fibrillar structure of collagen plays an equally important role. Therefore, we studied the interaction of the molecular and fibrillar structure of collagen with fibronectin. Atomic force and transmission electron microscopy showed that the presence of fibronectin does not affect the native structure and diameter of collagen fibrils. Confocal microscopy demonstrated that the collagen structure affects the cell morphology. Cells are better spread on molecular collagen compared with cells cultured on fibrillar collagen. Fibronectin promotes the formation of a large number of focal contacts, while in combination with collagen of both forms, its effect is leveled. Thus, understanding the mechanisms of the relationship between the protein structure and composition will effectively manage the creation in vitro of a new tissue with native properties.