Miracle-dz/UniFAR-FTUs huggingface dataset:
DNA barcoding of the horsefly fauna (Diptera, Tabanidae) of Croatia with notes on the morphology and taxonomy of selected species from Chrysopsinae and Tabaninae

﻿Abstract In the Croatian fauna, horseflies (Tabanidae) are represented by 78 species belonging to two subfamilies, five tribes, and 10 genera. Identification of these species is based on morphological characteristics. In this study, 43 species of horseflies were analyzed. The highest number of species (19) belongs to the genus Tabanus, followed by the genera Hybomitra with seven species, Haematopota with six species, Chrysops with four species, Atylotus and Philipomyia with two species each, and the genera Silvius, Dasyrhamphis, and Heptatoma with one species each. The standard DNA barcoding region of the mitochondrial cytochrome c oxidase gene, subunit I (COI), was sequenced and compared to the Barcode of Life Database (BOLD). Our analyses confirmed our morphological identifications and added 16 new Barcode Index Numbers (BINs) for Tabanidae to BOLD. Potential problems in the systematics and taxonomy of this family are highlighted.
Biochar Applied with Inorganic Nitrogen Improves Soil Carbon, Nitrate and Ammonium Content of a Sandy Loam Temperate Soil

Biochar is suggested to improve soil properties. However, its combination with inorganic nitrogen (N) fertilizer in temperate soils is not well understood. This study compared the effect of fertilizer N-biochar-combinations (NBC) and fertilizer-N (FN) on total soil N (TSN), soil organic carbon (SOC), soil nitrate (NO3−–N), and ammonium (NH4+–N). Soil samples were taken from experiments at Efaw and Lake Carl Blackwell (LCB), Oklahoma, USA with ten treatments consisting of three N rates (50, 100, and 150 kg N ha−1) and three biochar rates (5, 10, and 15 t ha−1). Results at Efaw showed greater TSN and SOC under NBC compared to FN by 3 and 21%, respectively. No percentage difference was observed for NH4+–N while NO3−–N was lower by 7%. At LCB, TSN, SOC, NO3−–N, and NH4+–N were higher under NBC by 5, 18, 24, and 10%, respectively, compared to FN. Whereas application of biochar improved SOC at both sites, NO3−–N and NH4+–N were only significant at LCB site with a sandy loam soil but not at Efaw with silty clay loam. Therefore, biochar applied in combination with inorganic N can improve N availability with potential to increase crop N uptake on coarse textured soils.
3D Reconstruction and Texture Refinement with Image Enhancement for Improved Visual Quality

This paper proposes a method to generate surface and texture models from rigid objects captured with an RGB-D camera. The method integrates five stages: 1. Point cloud generation from RGB-D images; 2. Surface model generation; 3. Surface model refinement; 4. Texture generation and mapping; 5. Texture enhancement. The use of image processing algorithms for texture enhancement and the refinement of the surface models enables the improvement of the appearance of reconstructed models. The performed experimentation shows the results of the proposed method for five small textured objects. The appearance of reconstructed models was evaluated using a visual quality index; a sharper texture helps to improve such index.
Patients’ Satisfaction with Healthcare Services at Private and Public Hospitals in Aseer Region

Assessments of patients’ satisfaction with provided health care is important, not only as a measure of the quality of care patients receive, but also in identifying potential areas for improving the content of care provided by physicians . Research proved that improving patient satisfaction with physician increases the likelihood that a patient will return to a given health care provider. Aim of Study: To assess patients’ satisfaction with healthcare services at private and governmental hospitals in Aseer Region, 2020. Methodology: Following a cross sectional design, two hospitals were included, a governmental hospital and a private hospital. A total of 400 patients were interviewed according to a consecutive sampling technique Conclusions: In both public and private hospitals, quality of provided health services is significantly less than that expected across all components of patients’ satisfaction. In public hospitals, higher quality of received health services is perceived by older patients. In private hospitals, higher quality of received health services is v older and male patients and those who have health insurance. Both received and expected quality of health services are significantly higher in private than public hospitals.
Distance and mismatch in graduate school selection

ABSTRACT We use the score reports of 375,000 US-based GMAT® test takers to document patterns of mismatch between student ability and school quality. We find substantial levels of mismatch in candidates' selection of MBA programs for score-sending, and by extension, applications. The evidence suggests that the high levels of mismatch in the selection of schools by candidates can explain some of the academic mismatch attributed to school policies. Using discrete choice models, we find candidates are discouraged by distance and motivated by in-state programs. We also find that much of the application overmatch is explained by candidates' preference for high-quality programs.
Women Tell All: A Comparative Thematic Analysis of Women’s Perspectives on Two Brief Counseling Interventions for Intimate Partner Violence

Background: Intimate partner violence (IPV) is a significant public health problem that is commonly experienced by women and associated with psychosocial health issues. Recovering from IPV through Strengths and Empowerment (RISE) is a brief, clinician-administered, variable-length (1–6 sessions), modular, individualized psychosocial counseling intervention developed for women experiencing IPV. We present qualitative feedback and quantitative helpfulness ratings from women patients of the Veterans Health Administration who completed a randomized clinical trial (RCT) comparing RISE to a clinician-administered advocacy-based Enhanced Care as Usual (ECAU; a single structured session consisting of psychoeducation, safety-planning, resources, and referrals). Methods: 58 participants (Mage = 39.21) completed post-intervention semi-structured qualitative interviews, including helpfulness ratings, at two follow-up assessments (10- and 14-weeks post-enrollment) to assess the acceptability, usefulness, and perceived fit of the interventions for women’s needs. Interviews were transcribed and analyzed using a hybrid deductive-inductive analytic approach. Results: While both the RISE and ECAU interventions were deemed helpful (interventions were rated as ‘highly helpful’ by 77% of RISE and 52% of ECAU participants), differences were identified in perceived impacts of the intervention, application of content, approach to patient-centeredness, and implementation recommendations. Conclusions: Findings shed light on women Veterans’ experiences and preferences for IPV psychosocial counseling interventions. Such knowledge can inform evidence-based, trauma-informed, and individualized care for women Veterans who experience IPV and may have relevance to other populations of women who experience IPV.
Biased β-Agonists Favoring Gs over β-Arrestin for Individualized Treatment of Obstructive Lung Disease

Signals from G-protein-coupled receptors (GPCRs) are the most frequently targeted pathways of currently prescribed therapeutics. Rather than being a simple switch, it is now evident that a given receptor can directly initiate multiple signals, and biasing to achieve signal selectivity based on agonist structure is possible. Biased agonists could direct therapeutically favorable pathways while avoiding counterproductive or adverse reaction pathways. For obstructive lung diseases, β2-adrenergic receptor (β2AR) agonists act at these receptors on airway smooth muscle (ASM) cells to open the airways by relaxing ASM, improving airflow and morbidity. However, these receptors signal to the G protein Gs (increasing cAMP and promoting relaxation), but also to β-arrestin (promoting desensitization and a loss of effectiveness). Indeed, β-agonist use is associated with adverse events in asthma pathogenesis and clinical outcomes which are related to desensitization. β-agonists favoring Gs coupling over β-arrestin binding would provide a means of tailoring bronchodilator therapy. In this review, we show how combinatorial methods with a 40 million compound agnostic library led to a new class of biased β-agonists that do not desensitize, providing an opportunity to personalize therapy in patients who experience poor efficacy or adverse effects from traditional balanced agonists.
The Effect of Trap Color on Catches of Monochamus galloprovincialis and Three Most Numerous Non-Target Insect Species

Simple Summary The pine sawyer, Monochamus galloprovincialis, is a longhorned beetle widespread in Europe. It develops in severely weakened, dying, or recently dead pine trees. The importance of M. galloprovincialis has increased since it was shown to be a vector of the alien and invasive pine wood nematode, Bursaphelenchus xylophilus, which can kill pines within a year. Pheromone traps are the most useful tools for monitoring M. galloprovincialis. While black traps are most commonly used, the objective of our studies was to test the attractiveness of different colors to immature and mature M. galloprovincialis and three non-target species. The results could be useful in selecting an optimal color that is attractive to M. galloprovincialis, but minimizes bycatch of non-target insects. A total of twenty colors were tested, including nine colors tested in the field, using cross-vane traps. The unpainted white traps were found to be most attractive to M. galloprovincialis and can be used to increase catches of this insect. However, the predatory beetles Thanasimus spp. responded to the trap color in the same way as M. galloprovincialis; therefore, either trap design or lure composition should be modified to reduce the impact on these beneficial insects. Abstract Black pheromone-baited traps are commonly used for monitoring Monochamus galloprovincialis, a vector of Bursaphelenchus xylophilus, although few studies have been conducted on its response to color (black, white, and clear). The objective of our studies was to evaluate the attractiveness of different colors to M. galloprovincialis and non-target species: Spondylis buprestoides and predatory Thanasimus formicarius and T. femoralis. Laboratory tests of fifteen colors against immature and mature M. galloprovincialis revealed some differences in their color preference. In two field tests, eight colors of coroplast vanes in cross-vane traps were compared with unpainted white (a reference (RF)). The first test confirmed the laboratory results, i.e., RF was slightly more attractive to M. galloprovincialis than pastel yellow, reseda green, and cyan blue, but trap color had no significant effect on any of the insect species studied. In the second test, the attractiveness of RF was highest and significantly different from pure white (for all four species), light blue, and pine green (except S. buprestoides). Overall, the unpainted white traps appeared to be most effective in catching M. galloprovincialis. Thanasimus spp. responded to the colors similarly to M. galloprovincialis; therefore, either trap design or lure composition should be modified to reduce their catches.
In It for the Long Haul: RE-AIM Evaluation of a Preschool Programme Implementing and Maintaining Adult-Initiated Motor Skill Development and Physical Activity across a Two-Year Period

Good motor skills (MS) are considered important for children’s social, psychological and physical development and general physical activity (PA) levels. The Motor skill in Preschool study (MiPS) aimed to optimize children’s MS through weekly PA sessions. The aim of this study is to use the RE-AIM framework to report the two-year implementation process of MiPS since the programme’s initiation. Data were collected through a staff questionnaire based on the RE-AIM framework. Data were collected at three months, one year and two years after initiation. Results show that the pedagogical staff believes that the programme promotes MS in children. Implementation measures only showed medium to low fidelity concerning the core element of performing adult-initiated PA sessions with a duration of at least 45 min 4 days a week. The largest barrier was finding the time to plan these PA sessions. Still, the content of the PA sessions achieved high fidelity scores and the programme was deemed suitable for staff’s everyday practice and in alignment with the stated pedagogical goals. The mandatory competence development course was highly valued as strong implementation support. It is notable that there is a large variation in the implementation among the preschools with some struggling more than others.
The Nutrition-Microbiota-Physical Activity Triad: An Inspiring New Concept for Health and Sports Performance

The human gut microbiota is currently the focus of converging interest in many diseases and sports performance. This review presents gut microbiota as a real “orchestra conductor” in the host’s physio(patho)logy due to its implications in many aspects of health and disease. Reciprocally, gut microbiota composition and activity are influenced by many different factors, such as diet and physical activity. Literature data have shown that macro- and micro-nutrients influence gut microbiota composition. Cumulative data indicate that gut bacteria are sensitive to modulation by physical activity, as shown by studies using training and hypoactivity models. Sports performance studies have also presented interesting and promising results. Therefore, gut microbiota could be considered a “pivotal” organ for health and sports performance, leading to a new concept: the nutrition-microbiota-physical activity triad. The next challenge for the scientific and medical communities is to test this concept in clinical studies. The long-term aim is to find the best combination of the three elements of this triad to optimize treatments, delay disease onset, or enhance sports performance. The many possibilities offered by biotic supplementation and training modalities open different avenues for future research.
Construction of Orthogonal Modular Proteinaceous Nanovaccine Delivery Vectors Based on mSA-Biotin Binding

Proteinaceous nanovaccine delivery systems have significantly promoted the development of various high-efficiency vaccines. However, the widely used method of coupling the expression of scaffolds and antigens may result in their structural interference with each other. Monovalent streptavidin (mSA) is a short monomer sequence, which has a strong affinity for biotin. Here, we discuss an orthogonal, modular, and highly versatile self-assembled proteinaceous nanoparticle chassis that facilitates combinations with various antigen cargos by using mSA and biotin to produce nanovaccines. We first improved the yield of these nanoparticles by appending a short sugar chain on their surfaces in a constructed host strain. After confirming the strong ability to induce both Th1- and Th2-mediated immune responses based on the plasma cytokine spectrum from immunized mice, we further verified the binding ability of biotinylated nanoparticles to mSA-antigens. These results demonstrate that our biotinylated nanoparticle chassis could load both protein and polysaccharide antigens containing mSA at a high affinity. Our approach thus offers an attractive technology for combining nanoparticles and antigen cargos to generate various high-performance nanovaccines. In particular, the designed mSA connector (mSA containing glycosylation modification sequences) could couple with polysaccharide antigens, providing a new attractive strategy to prepare nanoscale conjugate vaccines.
Structural Characterization and Osseointegrative Properties of Pulsed Laser-Deposited Fluorinated Hydroxyapatite Films on Nano-Zirconia for Implant Applications

Standard zirconia implants used in restoration still present problems related to inertness and long-term stability. Various physicochemical approaches have been used to modify the implant surfaces to improve early and late bone-to-implant integration; however, no ideal surface modification has been reported. This study used pulsed laser deposition to deposit a fluorinated hydroxyapatite (FHA) film on a zirconia implant to create a biologically active surface. The film prepared was uniform, dense, and crack-free, and exhibited granular surface droplets; it also presented excellent mechanical strength and favorable biological behavior. The FHA-coated implant was implanted on the femur of Sprague–Dawley rats, and various tests and analyses were performed. Results show that the in vitro initial cell activity on the FHA-coated samples was enhanced. In addition, higher alkaline phosphatase activity and cell mineralization were detected in cells cultured on the FHA-coated groups. Further, the newly formed bone volume of the FHA-coated group was higher than that of the bare micro-adjusted composite nano-zirconia (NANOZR) group. Therefore, the FHA film facilitated osseointegration and may improve the long-term survival rates of dental implants, and could become part of a new treatment technology for implant surfaces, promoting further optimization of NANOZR implant materials.
Role of Epicardial Adipose Tissue in Cardiovascular Diseases: A Review

Simple Summary Cardiovascular diseases (CVDs) are the leading causes of death worldwide. Epicardial adipose tissue (EAT) is one of the most important risk factors for cardiovascular events and a promising new therapeutic target in CVDs. Here, we summarize the currently available evidence regarding the role of EAT in the development of CVDs, including coronary artery disease, heart failure and atrial fibrillation; compile data regarding the association between EAT’s function and the course of COVID-19; and present new potential therapeutic possibilities, aiming at modifying EAT’s function. The development of novel therapies specifically targeting EAT could revolutionize the prognosis in CVDs. Abstract Cardiovascular diseases (CVDs) are the leading causes of death worldwide. Epicardial adipose tissue (EAT) is defined as a fat depot localized between the myocardial surface and the visceral layer of the pericardium and is a type of visceral fat. EAT is one of the most important risk factors for atherosclerosis and cardiovascular events and a promising new therapeutic target in CVDs. In health conditions, EAT has a protective function, including protection against hypothermia or mechanical stress, providing myocardial energy supply from free fatty acid and release of adiponectin. In patients with obesity, metabolic syndrome, or diabetes mellitus, EAT becomes a deleterious tissue promoting the development of CVDs. Previously, we showed an adverse modulation of gene expression in pericoronary adipose tissue in patients with coronary artery disease (CAD). Here, we summarize the currently available evidence regarding the role of EAT in the development of CVDs, including CAD, heart failure, and atrial fibrillation. Due to the rapid development of the COVID-19 pandemic, we also discuss data regarding the association between EAT and the course of COVID-19. Finally, we present the potential therapeutic possibilities aiming at modifying EAT’s function. The development of novel therapies specifically targeting EAT could revolutionize the prognosis in CVDs.
Pain in Persons with Disorders of Consciousness

Pain and suffering in persons with disorders of consciousness (DoC) remain poorly understood, frequently unaddressed or inadequately addressed, and controversial on numerous levels. This narrative literature review will address a number of critical issues germane to pain and suffering in this challenging group of patients, providing an introductory overview of the topic, perspectives on current knowledge regarding pain pathoanatomy and pathophysiology, and a review of common pain generators and factors that can lead to the chronifcation of pain. Caveats on bedside pain assessment challenges, as well as electrophysiologic and neuroimaging findings in these patients, will also be explored. Pain management techniques, including non-pharmacological and pharmacological, will be reviewed. Ethical considerations in the context of pain and suffering in persons with disorders of consciousness will round out the review prior to our concluding comments.
Formation Control of Quadrotor Vehicles

The use of multiple quadrotors to perform cooperative tasks is an active research ? eld of crucial importance. One particular mission of interest involves a formation of quadrotors performing infrastructure inspection autonomously. This thesis describes a scenario where a Target quadrotor is performing a task in a GPS-denied environment, and two Sensor quadrotors with GPS capabilities estimate the Target’s position combining their positions with bearings-only measurements. The selection of the Sensors’ positions can greatly a? ect the estimation performance, motivating the optimization of several objective functions based on the Fisher Information Matrix (FIM). Two novel estimation algorithms are created and tested for both cases where the Target is stationary and moving. The results show geometric con? gurations that increase the estimation accuracy, illustrating the importance of maximizing the FIM for Target localization using quadrotors. Assuming a double integrator model for the target vehicle, an LQR controller is combined with the nonlinear estimator to achieve tracking of a desired trajectory. The results show the in? uence of the Sensors’ positioning not only on the estimation error, but also on the di? erence between the true and desired position of the Target. Finally, a network localization problem with multiple Targets and two Sensors with full knowledge of their position is considered. The Targets estimate their position using not only bearings measurements coming from one of the Sensors, but also coming from another Target. A construction method of network formations that guarantees the convergence of the Targets’ estimates to their actual positions is described and demonstrated.
Exploring the Decisional Drivers of Deviance: A Qualitative Study of Institutionalized Adolescents in Malaysia

Adolescents who break the law or deviate from social norms are often criminalized as their behavior is perceived as resulting from conscious choices. However, it is likely that such choices result from their circumstances, namely the failure of their proximal environment to safeguard their wellbeing. The purpose of this study was to gain an in-depth understanding of the background variables and choices that led these institutionalized adolescents down the road of deviance. We conducted a qualitative study using semi-structured in-depth interviews, conducted between March and May 2018, with 18 participants aged between 15 to 19 years. Participants were purposefully sampled from various welfare institutions in the states of Kuala Lumpur and Selangor, Malaysia. Audio recordings of interviews were transcribed verbatim and analyzed thematically. We found three core themes, (i) Sources of Distress, (ii) Drivers of Deviance, and (iii) Adjustment Strategies for Coping with Distress, which appeared to have influenced participants’ life trajectories and eventual institutionalization. The findings showed that participants were disadvantaged by backgrounds of risk and vulnerability, characterized by a lack of social support and opportunities for personal development, negative schooling experiences, and negative peer interactions. Substance abuse, which provided a coping strategy for the participants, may have further contributed to their delinquency. Drawing upon the socio ecological model (SEM), we systematically identify interventional opportunities at the individual, community, and policy levels to safeguard the wellbeing of at-risk adolescents. We make recommendations aimed at improving the family dynamics, promoting a healthy schooling experience, and transforming neighborhoods into a safe and nurturing environment.