Miracle-dz/UniFAR-FTUs huggingface dataset:
Intergrated Evaluation Method for Fatigue Limit of Notched Steel with DKth Value

Abstract It is the big problem to evaluate the fatigue limit σw in order to safely design structures and machines. Under the condition of the fatigue crack initiation limit σw1, the present author defined the initial crack size √ using the characteristic elastic field of the notch, the half length of the fatigue crack a and a notch depth t. Using this√ , the methods of calculating ΔKth and σw1 were proposed. In addition to it, in this condition it is made sure that ΔKth exists on the band from ΔKth prediction line of the micro fatigue crack within 18% error. Using ΔKth calculated by the prediction line and the value of√ , this evaluating method of σw1 was confirmed with annealed 0.35% carbon steel. As a result, it was confirmed that this method to evaluate σw1 is within 18% error. Moreover it was also confirmed that the σw1 value by this prediction method is within 10% error when the predicted σw1 value is greater than σw2.
Neural mass spatio-temporal modeling from high-density electrode array recordings

Neural mass models provide an attractive framework for modeling complex behavior in cortical circuits. The models are based on describing the dynamics of large neural populations through the space and time evolution of a small number of key aggregate statistical quantities. Fitting these models to electrode array recordings can provide insight into connectivity and structure of neural circuits as well as the response of these circuits to stimuli. However, neural mass models are fundamentally nonlinear dynamical systems with large numbers of hidden states, and validating the models on actual recordings and estimating the key parameters remains challenging. This work proposes a novel method for systematically identifying neural mass models that is particularly well-suited for high-density micro-electrocorticographic (μECoG) data. The methodology requires minimal assumptions on the model, and can automatically uncover the underlying components in the neural populations We discuss possible applications to in vivo recordings from feline visual cortex using a recently-developed, high-density 360 contact flexible electrode array with 500 μm inter-electrode spacing.
Femtosecond-laser-produced low-density plasmas in transparent biological media: a tool for the creation of chemical, thermal, and thermomechanical effects below the optical breakdown threshold

The irradiance threshold for femtosecond optical breakdown in aqueous media is approximately equals 1.0x1013W cm-2. At the breakdown threshold, a plasma with a free electron density of about 1021cm-3 is generated, and the energy density in the breakdown region is sufficiently high to cause the formation of a bubble which can be experimentally observed. We found previously that plasmas with a free electron density <1021cm-3 are formed also in a fairly large irradiance range below the breakdown threshold. The present study investigates the chemical, thermal, and thermomechanical effects produced by these low-density plasmas. We use a rate equation model considering multiphoton ionization and produced by these low-density plasmas. We use a rate equation model considering multiphoton ionization and avalanche ionization to numerically simulate the temporal evolution of the free electron density during the laser pulse for a given irradiance, and to calculate the irradiance dependence of the free-electron density and volumetric energy density reached at the end of the laser pulse. The value of the energy density created by each laser pulse is then used to calculate the temperature distribution in the focal region after application of a single laser pulse and of series of pulses. The results of the temperature calculations yield, finally, the starting point for calculations of the thermoelastic stresses that are generated during the formation of the low-density plasmas. We found that, particularly for short wavelengths, a large 'tuning range' exists for the creation of spatially extremely confined chemical, thermal and mechanical effects via free electron generation through nonlinear absorption. Photochemical effects dominate at the lower end of this irradiance range, whereas at the upper end they are mixed with thermal effects and modified by thermoelastic stresses. Above the breakdown threshold, the spatial confinement is partly destroyed by cavitation bubble formation, and the laser-induced effects become more disruptive. Our simulations revealed that the highly localized ablation of intracellular structures and intranuclear chromosome dissection recently demonstrated by other researchers are probably mediated by free-electron- induced chemical bond breaking and not related to heating or thermoelastic stresses. We conclude that low density plasmas below the optical breakdown threshold can be a versatile tool for the manipulation of transparent biological media and other transparent materials. (enabling, e.g., the generation of optical waveguides in bulk glass). Low density plasmas may, however, also be a potential hazard in multiphoton microscopy and higher harmonic imaging.
Negative-GSP: An Efficient Method for Mining Negative Sequential Patterns

Different from traditional positive sequential pattern mining, negative sequential pattern mining considers both positive and negative relationships between items. Negative sequential pattern mining doesn't necessarily follow the Apriori principle, and the searching space is much larger than positive pattern mining. Giving definitions and some constraints of negative sequential patterns, this paper proposes a new method for mining negative sequential patterns, called Negative-GSP. Negative-GSP can find negative sequential patterns effectively and efficiently by joining and pruning, and extensive experimental results show the efficiency of the method.
Structured discriminative models for noise robust continuous speech recognition

Recently there has been interest in structured discriminative models for speech recognition. In these models sentence posteriors are directly modelled, given a set of features extracted from the observation sequence, and hypothesised word sequence. In previous work these discriminative models have been combined with features derived from generative models for noise-robust speech recognition for continuous digits. This paper extends this work to medium to large vocabulary tasks. The form of the score-space extracted using the generative models, and parameter tying of the discriminative model, are both discussed. Update formulae for both conditional maximum likelihood and minimum Bayes' risk training are described. Experimental results are presented on small and medium to large vocabulary noise-corrupted speech recognition tasks: AURORA 2 and 4.
Design and analysis of fault tolerant architectures by model weaving

Aspect-oriented modeling is proposed to design the architecture of fault tolerant systems. Notations are introduced that support the separate and modularized design of functional and dependability aspects in UML class diagrams. This notation designates sensitive parts of the architecture and selected architecture patterns that implement common redundancy techniques. A model weaver is presented that constructs both the integrated model of the system and the dependability model on the basis of the analysis sub-models attached to the architecture patterns. In this way fault tolerance mechanisms can be systematically analyzed when they are integrated into the system.
Styles of Physician Advice About Smoking Cessation in College Students

Abstract Objective: To examine whether young adult cigarette smokers who were in the precontemplation and contemplation stages of change for smoking cessation would differ in their evaluations of vignettes depicting 2 types of physician advice. Participants: Fifty-seven young adult cigarette smokers who were undergraduate students (49.1% female, mean age = 20.4 years) attending an urban university. Methods: Participants evaluated 2 written vignettes. Both vignettes depicted physicians using patient-centered communication styles. One vignette depicted a physician giving a patient direct advice to quit smoking and the other a physician using a motivational style of advice. Data were collected from September 2004 through May 2005. Results: Participants rated the motivational advice vignette as significantly more favorable compared to the direct advice vignette on all assessed dimensions (global satisfaction, general satisfaction, physician affective style, physician technical style, and physician communication style). Conclusion: Smokers preferred the motivational advice style to simple patent-centered advice.
Computerized Medical Imaging and Graphics Extraction of Time Activity Curves from Gated Fdg-pet Images for Small Animals' Heart Studies

Keywords: PET Small animal Time activity curve (TAC) Kinetic modeling MMRG Active contours Bayes rule a b s t r a c t We introduce a new approach to extract the input function and the tissue time activity curve from dynamic ECG-gated 18 F-FDG PET images. These curves are mandatory to model the myocardium metabolic rate of glucose for heart studies. The proposed method utilizes coupled active contours to track the myocardium and the blood pool deformations. Furthermore, a statistical approach is developed to model the blood and tissue activities and to correct for spillovers. The developed algorithm offers a reliable alternative to serial blood sampling for small animal cardiac PET studies. Indeed, the calculated MMRG value differs by 1.54% only from the reference value.
Phase I/II Study of Oncolytic HSVGM-CSF in Combination with Radiotherapy and Cisplatin in Untreated Stage III/IV Squamous Cell Cancer of the Head and Neck

Purpose: This study sought to define the recommended dose of JS1/34.5-/47-/GM-CSF, an oncolytic herpes simplex type-1 virus (HSV-1) encoding human granulocyte-macrophage colony-stimulating factor (GM-CSF), for future studies in combination with chemoradiotherapy in patients with squamous cell cancer of the head and neck (SCCHN). Experimental Design: Patients with stage III/IVA/IVB SCCHN received chemoradiotherapy (70 Gy/35 fractions with concomitant cisplatin 100 mg/m2 on days 1, 22, and 43) and dose-escalating (106, 106, 106, 106 pfu/mL for cohort 1; 106, 107, 107, 107 for cohort 2; 106, 108, 108, 108 for cohort 3) JS1/34.5-/47-/GM-CSF by intratumoral injection on days 1, 22, 43, and 64. Patients underwent neck dissection 6 to 10 weeks later. Primary end points were safety and recommended dose/schedule for future study. Secondary end points included antitumor activity (radiologic, pathologic). Relapse rates and survival were also monitored. Results: Seventeen patients were treated without delays to chemoradiotherapy or dose-limiting toxicity. Fourteen patients (82.3%) showed tumor response by Response Evaluation Criteria in Solid Tumors, and pathologic complete remission was confirmed in 93% of patients at neck dissection. HSV was detected in injected and adjacent uninjected tumors at levels higher than the input dose, indicating viral replication. All patients were seropositive at the end of treatment. No patient developed locoregional recurrence, and disease-specific survival was 82.4% at a median follow-up of 29 months (range, 19-40 months). Conclusions: JS1/34.5-/47-/GM-CSF combined with cisplatin-based chemoradiotherapy is well tolerated in patients with SCCHN. The recommended phase II dose is 106, 108, 108, 108. Locoregional control was achieved in all patients, with a 76.5% relapse-free rate so far. Further study of this approach is warranted in locally advanced SCCHN. Clin Cancer Res; 16(15); 4005–15. ©2010 AACR.
Efficacy and Safety of Carvedilol in Treatment of Heart Failure with Chronic Kidney Disease: A Meta-Analysis of Randomized Trials

Background—The safety and efficacy of different types of &bgr;-blocker therapy in patients with non–dialysis-dependent chronic kidney disease (CKD) and systolic heart failure (HF) are not well described. We assessed whether treatment of systolic HF with carvedilol is efficacious and safe in adults with CKD. Methods and Results—We performed a post hoc analysis of pooled individual patient data (n=4217) from 2 multinational, double-blinded, placebo-controlled, randomized trials, CAPRICORN (Carvedilol Postinfarct Survival Control in Left Ventricular Dysfunction Study) and COPERNICUS (Carvedilol Prospective Randomized, Cumulative Survival study). Primary outcome was all-cause mortality. Secondary outcomes included cardiovascular mortality, HF mortality, first HF hospitalization, the composite of cardiovascular mortality or first HF hospitalization, and sudden cardiac death. Non–dialysis-dependent CKD was defined by estimated glomerular filtration rate ⩽60 mL/min/1.73 m2, using the abbreviated Modification of Diet in Renal Disease equation. CKD was present in 2566 of 4217 (60.8%) of the cohort, 50.4% of whom were randomly assigned to carvedilol therapy. Within the CKD group, treatment with carvedilol decreased the risks of all-cause mortality (hazard ratio [HR], 0.76; 95% confidence interval [CI], 0.63 to 0.93; P=0.007), cardiovascular mortality (HR, 0.76; 95% CI, 0.62 to 0.94; P=0.011), HF mortality (HR, 0.68; 95% CI, 0.52 to 0.88; P=0.003), first hospitalization for HF (HR, 0.74; 95% CI, 0.61 to 0.88; P=0.0009), and the composite of cardiovascular mortality or HF hospitalization (HR, 0.75; 95% CI, 0.65 to 0.87; P<0.001) but was without significant effect on sudden cardiac death (HR, 0.76; 95% CI, 0.56 to 1.05; P=0.098). There was no significant interaction between treatment arm and study type. Carvedilol was generally well tolerated by both groups of patients, with an increased relative incidence in transient increase in serum creatinine without need for dialysis and other electrolyte changes in the CKD patients. However, in a sensitivity analysis among HF subjects with estimated glomerular filtration rate <45 mL/min/1.73 m2 (CKD stage 3b), the efficacy of carvedilol was not significantly different from placebo. Conclusions—This analysis suggests that the benefits of carvedilol therapy in patients with systolic left ventricular dysfunction with or without symptoms of HF are consistent even in the presence of mild to moderate CKD. Whether carvedilol therapy is similarly efficacious in HF patients with more advanced kidney disease requires further study.
Metal triflates as catalytic curing agents in self-healing fibre reinforced polymer composite materials

High performance, damage tolerant fibre reinforced polymer (FRP) composite materials are currently required to demonstrate no propagation of any sub-surface structural micro-cracking when under service load, thereby encouraging overdesign and limiting the inherent lightweight nature of such a material. By incorporating selfhealing functionalities, in-situ autonomous repair can be initiated in the event of damage to maintain structural integrity while ultimately realising lighter and more sustainable structures. We have demonstrated metal triflate initiated ring opening polymerisation (ROP) of epoxide resin [1] in FRPs to restore >99% of the host matrix fracture toughness after damage under Mode I tests. Optimising the polymer composition via differential scanning calorimetry (DSC) identified the key parameters to achieve autonomous curing under ambient conditions. Initial and self-healed performance was evaluated using FRP E-glass double cantilever beam (DCB) coupon mechanical test specimens with embedded microvascular channels for self-healing agent delivery. Full recovery of fracture toughness (>99%) was demonstrated while achieving the following requirements: low cost, low toxicity, autonomous curing, autonomous delivery, usability, manufacturing processability and applicability to existing aerospace and automotive maintenance programs. Brittle and ductile cohesive failure mechanisms resulted from inclusion of a solvent (ethyl phenylacetate) within the healing agent under low (10 wt%) and medium (25 wt%) concentrations. Therefore, the failure mechanism can be adapted as the solvent acts as a plasticiser in the self-healing agent. This was further confirmed by imaging fracture plane surfaces via scanning electron microscopy (SEM). The adhesive repair was typically ~100 μm in thickness, comparable to damage voids present in impact damaged FRP composite materials.
Infinite matrices, wavelet coefficients and frames

We study the action of A on f∈L2(ℝ) and on its wavelet coefficients, where A=(almjk)lmjk is a double infinite matrix. We find the frame condition for A-transform of f∈L2(ℝ) whose wavelet series expansion is known.
Constant-RMR implementations of CAS and other synchronization primitives using read and write operations

We consider asynchronous multiprocessors where processes communicate only by reading or writing shared memory. We show how to implement consensus, all comparison primitives (such as CAS and TAS), and load-linked/store-conditional using only a constant number of remote memory references (RMRs), in both the cache-coherent and the distributed-shared-memory models of such multiprocessors. Our implementations are blocking, rather than wait-free: they ensure progress provided all processes that invoke the implemented primitive are live. Our results imply that any algorithm using read and write operations, comparison primitives, and load-linked/store-conditional, can be simulated by an algorithm that uses read and write operations only, with at most a constant blowup in RMR complexity.
Quantum theory, the Church–Turing principle and the universal quantum computer

It is argued that underlying the Church–Turing hypothesis there is an implicit physical assertion. Here, this assertion is presented explicitly as a physical principle: ‘every finitely realizible physical system can be perfectly simulated by a universal model computing machine operating by finite means’. Classical physics and the universal Turing machine, because the former is continuous and the latter discrete, do not obey the principle, at least in the strong form above. A class of model computing machines that is the quantum generalization of the class of Turing machines is described, and it is shown that quantum theory and the 'universal quantum computer’ are compatible with the principle. Computing machines resembling the universal quantum computer could, in principle, be built and would have many remarkable properties not reproducible by any Turing machine. These do not include the computation of non-recursive functions, but they do include ‘quantum parallelism’, a method by which certain probabilistic tasks can be performed faster by a universal quantum computer than by any classical restriction of it. The intuitive explanation of these properties places an intolerable strain on all interpretations of quantum theory other than Everett’s. Some of the numerous connections between the quantum theory of computation and the rest of physics are explored. Quantum complexity theory allows a physically more reasonable definition of the ‘complexity’ or ‘knowledge’ in a physical system than does classical complexity theory.
Serpens X-1 observed by INTEGRAL

Here we report results of an INTEGRAL-AO1 observation of the X-ray burst and atoll source Ser X-1 performed in May 2003. The object was observed for a total on-source time of 400 ks but nearly 8 ◦ off-axis due to its amalgamation with an observation of SS 433, the pointing target source. Ser X-1 has been clearly detected up to 30 keV with unprecedented positional accuracy for high-energy emission. The 20-30 keV light curve showed substantial variability during the observation. Comparison with previous observations indicates that the source was in its high ("banana") state and displayed a soft spectrum during the INTEGRAL pointing. A (non simultaneous) radio-to-γ-rays broad-band spectral energy distribution is also presented for the first time and discussed.
Photovoltaik: Lehrbuch zu Grundlagen, Technologie und Praxis, 6. Auflage

Die Nutzung der Sonnenenergie ist gemäss der nationalen Energiestrategie 2050 ein wichtiger Pfeiler der zukünftigen Energieversorgung. Bundesrat und VSE unterstützen eine langfristig klimaneutrale Energieversorgung. Prognosen für Schweizer Dachund Fassadenflächen variieren hinsichtlich des Potenzials der Stromproduktion sehr stark (24–67 TWh). Weitere 15–52 TWh würden sich aus der Nutzung von geeigneten Freiflächen ergeben. Der VSE schätzt das Potenzial auf Dachflächen mit 41 TWh ein, jenes für Fassaden mit 17 TWh.
Recommendation with Mixture Probabilistic Matrix Factorization Huayu Li

With the rapid development of smart TV industry, a large number of TV programs have been available for meeting various user interests, which consequently raise a great demand of building personalized TV recommender systems. Indeed, a personalized TV recommender system can greatly help users to obtain their preferred programs and assist TV and channel providers to attract more audiences. While different methods have been proposed for TV recommendations, most of them neglect the mixture of watching groups behind an individual TV. In other words, there may be different groups of audiences at different times in front of a TV. For instance, watching groups of a TV may consist of children, wife and husband, husband, wife, etc in many US household. To this end, in this paper, we propose a Mixture Probabilistic Matrix Factorization (mPMF) model to learn the program preferences of televisions, which assumes that the preference of a given television can be regarded as the mixed preference of different watching groups. Specifically, the latent vector of a television is drawn from a mixture of Gaussian and the mixture number is the estimated number of watching groups behind the television. To evaluate the proposed mPMF model, we conduct extensive experiments with many state-of-the-art baseline methods and evaluation metrics on a real-world data set. The experimental results clearly demonstrate the effectiveness of our model.
Use of copeptin for rapid rule-out of acute myocardial infarction

Copeptin is currently understood as a quantitative marker of endogenous stress. It rises rapidly in multiple acute disorders including acute myocardial infarction. As a single variable, it has only modest diagnostic accuracy for acute myocardial infarction. However, the use of copeptin within a dual-marker strategy together with conventional cardiac troponin increases the diagnostic accuracy and particularly the negative predictive value of cardiac troponin alone for acute myocardial infarction. The rapid rule-out of acute myocardial infarction is the only application in acute cardiac care mature enough to merit consideration for routine clinical care. However, the dual-marker approach seems to provide only very small incremental value when used in combination with sensitive or high-sensitivity cardiac troponin assays. This review aims to update and educate regarding the potential and the procedural details, as well as the caveats and challenges of using copeptin in clinical practice.