Miracle-dz/UniFAR-FTUs huggingface dataset:
Potential synergistic effects of cranial radiotherapy and atezolizumab in non-small cell lung cancer: an analysis of individual patient data from seven prospective trials

Background The impact of cranial radiotherapy (RT) on overall survival (OS) of patients with brain metastasis (BM) from non-small cell lung cancer (NSCLC) receiving programmed death 1/programmed death-ligand 1 (PD-1/PD-L1) inhibitors remains unclear. We aimed to examine the effect of previous cranial RT on the efficacy and neurological toxicity of PD-1/PD-L1 inhibitors in the treatment of patients with NSCLC. Methods Patient-level data from seven prospective trials involving atezolizumab for the treatment of NSCLC [BIRCH (NCT02031458), FIR (NCT01846416), IMpower130 (NCT02367781), IMpower131 (NCT02367794), IMpower150 (NCT02366143), OAK (NCT02008227), and POPLAR (NCT01903993)] were pooled. Patients with baseline BM were divided into two subgroups based on previous cranial RT before initiation of treatment: patients with previously irradiated BM (iBM) and patients with non-irradiated BMs (niBM). Results The per-protocol population consisted of 4,714 patients, including 3,176 in the atezolizumab group and 1,538 in the comparator chemotherapy group. In the atezolizumab group, OS was better in patients with BM (n=308) compared to patients without BM (n=2,868) [hazard ratio (HR): 0.83; 95% confidence interval (CI): 0.70–0.98; P=0.028]. Among patients with BM, patients with iBM (n=280) had a numerically longer OS (HR: 0.66; 95% CI: 0.41–1.07; P=0.090) than those with niBM (n=28). Intriguingly, OS was longer in patients with iBM than those without BM before (HR: 0.83; 95% CI: 0.70–0.99; P=0.043) and after (HR: 0.40; 95% CI: 0.32–0.49; P<0.0001) propensity score matching, while OS was similar between patients with niBM and those without BM. The survival advantage of patients with iBM over those without BM was not observed in the chemotherapy group. Atezolizumab-related serious neurological adverse events occurred in 16 (0.6%) patients without BM, none in those with niBM, and 2 (0.7%) patients with iBM. Conclusions These data suggest potential synergistic effects of cranial RT and anti-PD-(L)1 therapy in NSCLC patients, which warrants further validation.
KARAKTERISTIK FISIKOKIMIA TEPUNG TEMPE KECAMBAH KEDELAI (Physichochemical characteristics of germinated soybean tempe flour )

This research was conducted to compare physicochemical characteristics of germinated soybean tempe flour (GST flour) and soybean tempe flour (ST flour). Soybean was germinated within 28 hours and then processed into tempe. Germinated soybean tempe and soybean tempe were freeze-dried for 26 hours, and then milled into GST flour and ST flour. The GST flour and ST flour were used for physical and chemical analysis. The used of germinated soybean was proven to affect the quality of flour. GST flour had 53.37 % db protein, 24.97 mg AEAC antioxidant capacity/100 g tempe, 5.08 mg tocopherol/100 g db, 81.75 mg isoflavone/100 g db, and minerals (Ca, P, Fe, Zn) which were higher than that of the ST flour. GST flour also had better quality than that of ST flour, in term of: higher bulk density (0.42 g/ml), lower water activity (0.63), and lower repose angle (39.94 o ).
Harvesting small trees for bio-energy

A conventional whole-tree logging operation consisting of 4-wheeled and 3-wheeled saw-head feller-bunchers, two grapple skidders and a chipper that produces dirty chips was monitored across several stands and machine performance evaluated. Stands were inventoried to determine density, volume, and basal area per acre and will be used to relate machine performance to stand characteristics. Costs per hour and per ton will be calculated for each function and a total system cost will be determined for the conventional system. These costs will be used to compare the conventional system to a newly designed system for harvesting trees for bio-energy.
AlGaAs Tunnel Junction (TJ)-VCSELs: A NEGF–Drift-Diffusion Approach

This work reports a multiscale physics-based approach aimed at investigating the benefits of introducing a single tunnel junction (TJ) within conventional AlGaAs Vertical-Cavity Surface-Emitting Lasers (VCSELs). Our comprehensive VCSEL solver VENUS is augmented with a non-equilibrium Green's function (NEGF) approach to extract the band-to-band tunneling rate across the TJ. To showcase the NEGF-VENUS features, we apply it to the commercial pin oxide confined AlGaAs VCSEL previously investigated by VENUS, by inserting a TJ with minimal variations to the optical resonator. Besides finding the optimal position of TJ and oxide aperture, we can also compare the different hole injection schemes in the active region. Our results show the potential of doubling the maximum output power with the same threshold current, with perspectives of further enhancement by stacking more tunnel junctions.
Relationships among supervisor support, autonomy, job satisfaction and emotional labor on nurses within the Turkey context of healthcare services

Introduction Healthcare professionals face the challenging task of regulating their emotions within the workplace, which can lead to significant pressure and stress. For nurses, who work in particularly demanding environments, fulfilling the expectations of emotional labor can be challenging. Methods This study explores how nurses’ perceptions of supervisor support and job autonomy can positively influence emotional labor and job satisfaction via Partial Least Squares Structural Equation Modeling (PLS-SEM) technique. Results and discussion Job autonomy is found to negatively affect emotional labor but positively impact job satisfaction. Additionally, job satisfaction is a significant precursor to both surface and deep-acting dimensions of emotional labor. Furthermore, job satisfaction mediates the relationship between supervisor support and deep-acting emotional labor, as well as between job autonomy and both surface and deep-acting emotional labor. These findings shed light on the complex dynamics of emotional labor and job satisfaction in healthcare settings.
Early Childhood Environmental Education in Tropical and Coastal Areas: A Meta-Analysis

Early childhood years are the period of the greatest and most significant developments in ones’ life, and are generally regarded as the basis upon which the rest of their life is constructed. However, these early years are those that traditionally have received the least attention from environmental education. This paper was aimed to summarize several day-to-day activities that can be conducted to educate children in their early years about environment. Environmental education is an educational process that deals with the human interrelationships with the environment, and that uses an interdisciplinary problem solving approach with value clarification. Environmental education is aimed at producing a community that is knowledgeable about the biophysical environment and its associated problems, aware of how to solve these problems, and enthusiastic to work toward their solution. It highlights the progress of knowledge, understanding, attitudes, skills, and commitment for environmental problems and considerations. Further, environmental education can help children expand their ecological worldview, promote active care to the environment, and explain the relationship between modern life style and current environmental problems. Several types of environmental education have been identified from the literature, such as outdoor activities in natural outdoor setting, school gardening, play-based learning, and drawing activities. Each of these activities has its own characteristics and effects on children’s environmental-related attitudes and behaviors. Through these activities, the unique characteristics of tropical and coastal areas can potentially be used to facilitate children to learn about nature and environment. Recommendations for childhood education practitioners and future researchers are discussed.
Quantitative three‐dimensional ice roughness from scanning electron microscopy

We present a method for inferring surface morphology of ice from scanning electron microscope images. We first develop a novel functional form for the backscattered electron intensity as a function of ice facet orientation; this form is parameterized using smooth ice facets of known orientation. Three‐dimensional representations of rough surfaces are retrieved at approximately micrometer resolution using Gauss‐Newton inversion within a Bayesian framework. Statistical analysis of the resulting data sets permits characterization of ice surface roughness with a much higher statistical confidence than previously possible. A survey of results in the range −39°C to −29°C shows that characteristics of the roughness (e.g., Weibull parameters) are sensitive not only to the degree of roughening but also to the symmetry of the roughening. These results suggest that roughening characteristics obtained by remote sensing and in situ measurements of atmospheric ice clouds can potentially provide more facet‐specific information than has previously been appreciated.
Anti-ZSCAN1 Autoantibodies Are a Feasible Diagnostic Marker for ROHHAD Syndrome Not Associated with a Tumor

Recent studies have reported the presence of autoantibodies against zinc finger and SCAN domain-containing protein 1 (ZSCAN1) in the sera of patients with rapid-onset obesity with hypoventilation, hypothalamic and autonomic dysregulation (ROHHAD) syndrome associated with neuroendocrine tumors, suggesting immunologic and paraneoplastic processes as the pathologic underpinnings. Moreover, several hypothalamic regions, including the subfornical organ (SFO), were reported to exhibit antibody reactivity in a patient with ROHHAD syndrome not associated with a tumor. Whether ROHHAD syndrome not associated with a tumor is associated with anti-ZSCAN1 autoantibodies remains unclear. We used a comprehensive protein array analysis to identify candidate molecules in the sera of patients with ROHHAD syndrome and identified ZSCAN1 as a target antigen. We also found that ZSCAN1 was co-expressed at the site of antibody reactivity to the IgG in the patient serum observed in mouse SFOs and an enzyme-linked immunosorbent assay showed that >85% of the patients with ROHHAD syndrome were positive for anti-ZSCAN1 autoantibodies. These results suggest anti-ZSCAN1 autoantibodies as a feasible diagnostic marker in ROHHAD syndrome regardless of the presence of a tumor.
Contribution to our knowledge of macroinvertebrate fauna of theDyje River downstream of the Nové Mlýny Reservoirs (CzechRepublic)

Between 1998 and 1999, research of macrozoobenthos of the Dyje River below the Nove Mlýny Reservoirs was carried out with the objective to evaluate the impact of the reservoirs on the river biota. In this paper, the faunistic data from this research are presented. Altogether, 261 mostly benthic macroinvertebrates were found including several rare and endangered species (e.g. Lithoglyphus naticoides, Viviparus acerosus, Pseudanodonta complanata, Unio crassus, Pisidium moitessierianum, Heptagenia coerulans, Gomphus flavipes, Cymatia rogenhoferi). Some species represent first finds in the area, i.e. in the proposed extended area of the Palava Biosphere Reserve. The mayfly Baetis pentaphlebodes has not been published from the Czech Republic yet.
Human‐affected disturbances in vegetation cover and peatland development in the late Holocene recorded in shallow mountain peatlands (Central Sudetes, SW Poland)

The aim of this study is to assess the impact of biotic and abiotic factors on peatland formation in the Central Sudetes (central Europe) during the late Holocene. The research methodology adopted allowed us to determine whether vegetation development and shallow peatland formation were affected by human activity. Knowledge of past changes might be useful in evaluating recent and future changes, and to avoid pitfalls in the present management of peatland ecosystems. A palaeoecological research study of four peatlands was conducted in the Stołowe Mountains (Central Sudetes, SW Poland). The results showed that these shallow peatlands originated in the middle to late Holocene (from 3301 BC to AD 1137). Palaeoecological records reflect continuous human impact on vegetation development and peat accumulation from the Middle Ages to the present (late Holocene). The strongest agrarian settler activity is observed in the High Middle Ages (AD 1200–1500). The human‐induced or wildfires observed in the late Holocene were an integral component of peatland ecosystems in the Central Sudetes. Moreover, palaeoecological analysis (sphagnum spores decline) and radiocarbon dating (AD 1870) confirmed drainage of the study area in the 19th century, which greatly affected the vegetation communities.
INFLUENCE OF ORTHODONTIC TREATMENT ON BUCCAL CORRIDOR: A SYSTEMATIC REVIEW

Objective: To perform a review to assess the influence of orthodontic treatment on buccal corridor dimension. Material and methods: A search was conducted on MEDLINE, Scopus, and Web of Science databases to identify studies published in the last decade. Inclusion criteria consisted of clinical studies and systematic reviews evaluating the influence of orthodontic treatment on buccal corridor. Narrative reviews and studies not evaluating the relationship between buccal corridor and type of orthodontic treatment were excluded. Results: Among a total of 336, 326 were excluded after reading the abstract and 10 (nine clinical studies and one systematic review) were read in full. Conclusions: There was no direct relationship between orthodontic treatment with dental extractions and buccal corridor width. However, this treatment was found to be related to expansion and reduction of buccal corridor dimension
The Informational Role of Thin Options Markets: Empirical Evidence of the Spanish Case (El Papel Informativo De Los Mercados De Opciones Estrechos: Evidencia Empírica Del Caso Español)

English Abstract: This study investigates the informational role of thin options markets, specifically the Spanish options market. Firstly, we examine the effect of options markets by analysing stock market reaction to earnings news, conditional on the availability of options markets. Secondly, we examine options-trading activity before the release of earnings news (including the announcement period). Results show that the impact on prices before the earnings release is significantly bigger when options trading is available. Moreover, the dissemination of earnings news is associated with significant unusual activity in the options market due to informed trading, especially when the earnings surprise is highly good.Spanish Abstract: El trabajo analiza el papel informativo de los mercados de opciones para el caso de escasa negociacion, centrandose en el mercado espanol. Estudiamos el efecto de la llegada de nueva informacion relevante, como es el anuncio de beneficios, en el mercado de contado bajo la presencia de opciones sobre dichas acciones. Ademas, examinamos la actividad negociadora en el mercado de opciones ante dicho suceso. Los resultados muestran que el impacto de la informacion es superior cuando existen opciones cotizadas sobre dichas acciones. Adicionalmente, se observa una actividad negociadora anormal en el mercado de opciones debido a la negociacion informada, principalmente cuando la noticia es muy buena.
Water Stress and Grape Physiology in the Context of Global Climate Change*

Abstract Plant adaptation to global climate change has become one of the most pressing and important topics in biology. Changes in climate that lead to increased crop water use or decreases in water availability will increase the frequency and magnitude of plant water stress. Water stress reduces plant growth and crop yield, and for perennial crops like grape, there is an added consideration: their long-term ability to tolerate and recover from this stress. This primer introduces plant water relations basics, explaining how grape physiology is affected by water stress and discussing the physiological foundations for the development of drought-tolerant cultivars and rootstocks. (JEL Classifications: Q13, Q54)
The Effect of Non-Overlapping Somatic Mutations in BRAF, NRAS, NF1, or CKIT on the Incidence and Outcome of Brain Metastases during Immune Checkpoint Inhibitor Therapy of Metastatic Melanoma

Simple Summary Patients with metastatic melanoma have a high risk of brain involvement (brain metastases). It is not currently known whether the genetic subtype of melanoma affects the risk of brain metastases. We evaluated 85 patients who had mutation testing of their melanoma. All patients were treated with immunotherapy. Only 20% developed brain metastases. Patients with BRAF and NF1 mutations were the only ones who had brain metastases when metastatic melanoma was diagnosed (12.9%). Rare patients with BRAF, NRAS, NF1, or CKIT mutations developed delayed brain metastases following immunotherapy (7.1%). Patients who did not have any of these four mutations did not develop brain metastases. Patients who developed brain metastases from melanoma had a lower survival rate than those without brain metastases. Genetic sequencing of cancer tissues in individual patients is useful in determining the risk of brain involvement. This may allow more efficient monitoring strategies to be developed. Abstract Previous studies suggested that somatic BRAF and NRAS mutations in metastatic melanoma increase the risk for brain metastases. The risk related to other non-overlapping “driver” mutations is unknown. We performed a retrospective evaluation of the incidence, timing, and outcome of brain metastases in a population of melanoma patients that underwent uniform next-gen sequencing. All patients were treated with initial checkpoint inhibitor therapy. Seventeen of 88 patients (20.0%) developed brain metastases. Eleven patients had brain metastases at diagnosis (12.9%). These were all patients with BRAF V600 or NF1 mutations. Only six patients with NRAS, NF1, KIT, or BRAF mutations (including fusions/internal rearrangements experienced delayed CNS progression following immunotherapy (7.1%)). No “quadruple negative” patient developed brain metastases. Patients with brain metastases at diagnosis had a better outcome than those with delayed intracranial progression. Current predictive markers, (LDH, tumor mutation burden, and PDL1) were poorly correlated with the development of brain metastases. Treatment with immunotherapy appears to reduce the incidence of brain metastases. Next-gen molecular sequencing of tumors in metastatic melanoma patients was useful in identifying genetic subpopulations with an increased or reduced risk of brain metastases. This may allow eventual personalization of screening strategies.
Voluntary Collaboration for Adaptive Governance

The Southeast Florida Regional Climate Change Compact (SFRCCC) has been highlighted as a regional climate change governance exemplar for land use planning. After six years, we find the compact has given momentum to local climate change planning through the Regional Climate Action Plan and provides a foundation for adaptive governance for climate change adaptation. We also find aspects of the compact lacking in terms of representation, decision making, learning, and problem responsiveness. Efforts are now needed to scale down implementation and scale up governance and planning more systematically to address climate change adaptation needs at multiple levels.
Variation of small strain stiffness for piping-influenced Toyoura sand

Landslides triggered by piping are frequently reported during stormy periods. Despite large amount of model tests related with internal erosion, there is little research on the mechanical properties of disturbed soil by means of element experiment. In this paper, an attempt was made to create artificial piping by dissolving water soluble material (glucose) in sand. Chains of voids were generated when water was infiltrated and drained out through the specimen. Small torsional cyclic loadings were conducted on the hollow cylindrical specimens in order to obtain the small strain stiffness of the soil before/after piping erosion. According to the results, reduction of shear modulus was found in specimen with internal pipes after water infiltration, and piping-induced anisotropy was found to be obvious.
Multi-sensor wetland mapping over the Peace Athabasca Delta

The joint use of diverse sensors is of major interest in the remote sensing community. With view to the repeata-bility of acquisitions, todays satellite sensor systems provide a temporal resolution of about one month in the Shannon sense. Thus, the joint use of different sensor systems is unavoidable for monitoring purposes. This contribution designs a novel similarity transformation that extracts class similarities based on local distributions from any available image independent of sensor (TerraSAR-X, RADARSAT-2, Sentinel-1) or polarimetric mode (Quad, Dual-Co, Dual-Cross, Single). The resulting class probability development characterizes the temporal change of the Peace Athabasca Delta in Northern Canada.
Effect of orthodontic premolar extraction on maxillary teeth angulation and arch dimensions in adolescent patients: A 3-D digital model analysis

Background Therapeutic orthodontic premolar extraction is a common orthodontic treatment, yet the extent of its impact on the upper dental arch dimensions and teeth angulations is still under exploration. Hypothesis: We postulated that the therapeutic extraction of orthodontic premolars significantly alters the orientation of teeth and the dimensions of the dental arch. Objective: This study assessed the impact of therapeutic orthodontic premolar extraction on dental arch dimensions and tooth angulations. Material and Methods We conducted a retrospective cohort study involving 30 patients who underwent bilateral upper premolar extraction and fixed appliance treatment. Pre and post-treatment dental casts were scanned, and changes in tooth angulations and arch dimensions were evaluated using 3D digital maxillary models. Statistical analyses encompassed the application of paired samples t-test. Results Significant post-treatment changes were observed, including distal tipping in anterior teeth, minor mesial tipping in first molars, and a reduction in torque for central incisors and canines. Dental arch dimensions were also influenced, with increased width and depth between the canines and decreased width between the second premolars while inter-molar width and overall arch depth significantly reduced post-treatment. Conclusions Therapeutic orthodontic premolar extraction significantly affects dental arch dimensions and tooth angulations. These findings have implications for treatment planning and predicting changes associated with orthodontic treatments involving premolar extraction. Key words:3D digital models - orthodontic premolar extraction - teeth angulation - dental arch dimensions.
Las tecnologías de información y comunicación como prácticas de referencia en la gestión de conocimiento: una revisión sistemática de la literatura

El objetivo de este estudio es identificar las practicas de referencia apoyadas en Tecnologias de Informacion y Comunicacion, que favorecen la implementacion de la gestion de conocimiento en las organizaciones. Basada en la metodologia de revision sistematica, esta investigacion se desarrollo en tres fases: el desarrollo del protocolo de investigacion; la recoleccion y analisis de informacion de la base de datos Social Sciences Citation Index (SSCI) del Institute for Scientific Information (ISI); y finalmente, la generacion de resultados. El estudio realizado revela que las practicas de gestion relacionadas con aplicaciones y herramientas, bases de datos, comunidades de practica, frameworks y networks, aplicadas en contextos empresariales reales, promueven la obtencion de buenos resultados en los procesos asociados a la gestion de conocimiento.