Miracle-dz/UniFAR-FTUs huggingface dataset:
Coordinated Spectral and Temporal H alpha Observations of a Solar Flare

We report simultaneous observations of a flare (1991 January 11 18:25 UT) with a combination of spectra and high time resolution images in H-alpha. The Mees Solar Observatory CCD Imaging Spectrograph obtains spectra and spectroheliograms with a repetition rate of 14 s. These data permit the identification of sites of nonthermal electron precipitation or of high coronal pressure. We observe extremely strong electron precipitation in this flare; we find reasonable agreement between the observed profiles and theoretical precipitation spectra. We discuss the possibility that the spectra classed as precipitation signatures are in fact the result of a projection effect, and we indicate limitations of the one-dimensional theoretical models.
Comparative phylogeography reveals the demographic patterns of neotropical ancient mountain species

Mountains are renowned for their bountiful biodiversity. Explanations on the origin of such abundant life are usually regarded to their orogenic history. However, ancient mountain systems with geological stability also exhibit astounding levels of number of species and endemism, as illustrated by the Brazilian Quartzitic Mountains (BQM) in Eastern South America. Thus, cycles of climatic changes over the last couple million years are usually assumed to play an important role in the origin of mountainous biota. These climatic oscillations potentially isolated and reconnected adjacent populations, a phenomenon known as flickering connectivity, accelerating speciation events due to range fragmentation, dispersion, secondary contact, and hybridization. To evaluate the role of the climatic fluctuations on the diversification of the BQM biota, we estimated the ancient demography of distinct endemic species of animals and plants using hierarchical approximate Bayesian computation analysis and Ecological Niche Modelling. Additionally, we evaluated if climatic oscillations have driven a genetic spatial congruence in the genetic structure of codistributed species from the Espinhaço Range, one of the main BQM areas. Our results show that the majority of plant lineages underwent a synchronous expansion over the Last Glacial Maximum (LGM, c. 21 thousand years ago), although we could not obtain a clear demographic pattern for the animal lineages. We also obtained a signal of a congruent phylogeographic break between lineages endemic to the Espinhaço Range, suggesting how ancient climatic oscillations might have driven the evolutionary history of the Espinhaço's biota.
Psychedelic Treatments for Substance Use Disorder and Substance Misuse: A Mixed Methods Systematic Review

ABSTRACT Renewed interest in psychedelic substances in the 21st century has seen the exploration of psychedelic treatments for various psychiatric disorders including substance use disorder (SUD). This review aimed to assess the effectiveness of psychedelic treatments for people with SUD and those falling below diagnostic thresholds (i.e. substance misuse). We systematically searched 11 databases, trial registries, and psychedelic organization websites for empirical studies examining adults undergoing psychedelic treatment for SUD or substance misuse, published in the English language, between 2000 and 2021. Seven studies investigating treatment using psilocybin, ibogaine, and ayahuasca, alone or adjunct with psychotherapy reported across 10 papers were included. Measures of abstinence, substance use, psychological and psychosocial outcomes, craving, and withdrawal reported positive results, however, this data was scarce among studies examining a wide range of addictions including opioid, nicotine, alcohol, cocaine and unspecified substance. The qualitative synthesis from three studies described subjective experience of psychedelic-assisted treatments enhanced self-awareness, insight, and confidence. At present, there is no sufficient research evidence to suggest effectiveness of any of the psychedelics on any specific substance use disorder or substance misuse. Further research using rigorous effectiveness evaluation methods with larger sample sizes and longer-term follow-up is required.
Prediction of outcome after ligation or thin film banding of extrahepatic shunts, based on plasma albumin concentration and hematologic expression of 8 target genes in 85 dogs

Abstract Background In dogs with a congenital extrahepatic portosystemic shunt (EHPSS), outcome after surgical attenuation is difficult to predict. Objectives Develop a minimally invasive test to predict outcome after surgical EHPSS attenuation and establish risk factors for postattenuation seizures (PAS). Animals Eighty‐five client‐owned dogs referred for surgical attenuation of a single EHPSS. Methods mRNA expression of 8 genes was measured in preoperatively collected venous blood samples. Outcome was determined at a median of 92 days (range, 26‐208) postoperatively by evaluating clinical performance, blood test results and abdominal ultrasonography. Multivariable logistic regression was used to construct models predicting clinical and complete recovery. The associations between putative predictors and PAS were studied using univariable analyses. Results Five of 85 dogs developed PAS. Risk factors were age, white blood cell (WBC) count and expression of hepatocyte growth factor activator and LysM and putative peptidoglycan‐binding domain‐containing protein 2. Clinical recovery was observed in 72 of 85 dogs and complete recovery in 51 of 80 dogs (median follow‐up, 92 days). The model predicting clinical recovery included albumin, WBC count, and methionine adenosyltransferase 2 alpha (MAT2α) expression, whereas the model predicting complete recovery included albumin, and connective tissue growth factor precursor and MAT2α expression. The areas under the receiver operating characteristic curves were 0.886 (95% confidence interval [CI]: 0.783, 0.990) and 0.794 (95% CI: 0.686, 0.902), respectively. Conclusions and Clinical Importance Two models were constructed for predicting outcome after EHPSS attenuation using venous blood samples. The model predicting clinical recovery showed the best diagnostic properties. Clinical application requires further validation.
Shared reality, memory goal satisfaction, and psychological well-being during conversational remembering

ABSTRACT Conversational remembering, or sharing autobiographical memories with others, occurs frequently in everyday communication. The current project examined how the experience of shared reality with a conversation partner when describing autobiographical memories to them can operate to enhance the self, social, and directive uses of a recalled memory and explored the role of shared reality experienced as a result of conversational remembering in psychological well-being. In this project, conversational remembering was examined using experimental (Study 1) and daily diary (Study 2) methodologies. Results indicated that experiencing a shared reality during conversational remembering of an autobiographical memory enhanced self, social, and directive memory goal fulfilment and was positively associated with greater psychological well-being. The current investigation highlights important benefits of sharing our life stories with others, especially those with whom we develop a sense of shared reality.
COVID-19 stigma and depression across race, ethnicity and residence

ABSTRACT Our cross-sectional study seeks to understand how COVID-19 stigma, race/ethnicity [Asian, Black, Hispanic/Latinx, white] and residency [New York City (NYC) resident vs. non-NYC resident] associated with depression. Our sample includes 568 participants: 260 (45.77%) were NYC residents and 308 (54.3%) were non-NYC residents. A series of multiple linear regression were run to examine the relationship between race/ethnicity, COVID-19 stigma, and depressive symptoms. Irrespective of residency, older age and ever being diagnosed with COVID-19 were negatively associated with depressive symptoms. Stigma and thinking less of oneself significantly associates with depressive symptoms across residency. Our study expects to benefit mental health care providers and public health professionals in designing best practices to mitigate stigma in ongoing or future pandemics.
Cluster randomised trial of a complex interprofessional intervention (interprof ACT) to reduce hospital admission of nursing home residents

Abstract Background Some hospital admissions of nursing home residents (NHRs) might be attributed to inadequate interprofessional collaboration. To improve general practitioner–nurse collaboration in nursing homes (NHs), we developed an intervention package (interprof ACT) in a previous study. Objective To assess the impact of interprof ACT on the proportion of hospitalisation and other clinical parameters within 12 months from randomisation among NHRs. Methods Multicentre, cluster randomised controlled trial in 34 German NHs. NHRs of the control group received usual care, whereas NHRs in the intervention group received interprof ACT. Eligible NHs had at least 40 long-term care residents. NHs were randomised 1:1 pairwise. Blinded assessors collected primary outcome data. Results Seventeen NHs (320 NHRs) were assigned to interprof ACT and 17 NHs (323 NHRs) to usual care. In the intervention group, 136 (42.5%) NHRs were hospitalised at least once within 12 months from randomisation and 151 (46.7%) in the control group (odds ratio (OR): 0.82, 95% confidence interval (CI): [0.55; 1.22], P = 0.33). No differences were found for the average number of hospitalisations: 0.8 hospitalisations per NHR (rate ratio (RR) 0.90, 95% CI: [0.66, 1.25], P = 0.54). Average length of stay was 5.7 days for NHRs in the intervention group and 6.5 days in the control group (RR: 0.70, 95% CI: [0.45, 1.11], P = 0.13). Falls were the most common adverse event, but none was related to the study intervention. Conclusions The implementation of interprof ACT did not show a statistically significant and clinically relevant effect on hospital admission of NHRs.
Mid-Tropospheric Cyclones of the Southwest Monsoon

Abstract Mid-tropospheric cyclones are an important part of the tropical general circulation of the summer season. These are synoptic-scale disturbances which appear in the daily and monthly mean circulation maps with greatest intensity at levels near 500 mb. The structure and energetics of this type over southeast Asia are discussed in this paper. Interesting features include a warm anomaly above the cyclone and a cold anomaly below. A five-level non-geostrophic balanced model is used in this study to obtain the distribution of vertical motion. The model includes a parameterization of cumulus-scale convection. In the middle levels, rising motions are found west of the cyclone and sinking motions to the east. This is primarily due to the thermal structure of the atmosphere and associated advection of colder air from the oceanic regions and warmer air from land areas. A marked diurnal change in the vertical velocity is noted in the computations; magnitudes are large at 0700 local time compared to 1900. Thi.
Social Places and Senior Pupils' Identity in a Secondary School Environment: An Interpretative Phenomenological Analysis

Abstract:This paper investigates the relationship between the school environment and senior pupils' identity development in a secondary school in Scotland. The study used semi-structured interviews and Photovoice along with Interpretative Phenomenological Analysis, to explore senior pupils' experience of the social places within their school. The findings reveal the relationship between the places that pupils can access for social interaction and their sense of identity, and their use of territoriality to protect these specific places. The findings are considered in the context of the role of the school environment, pupils' needs and their implications for school design and planning.
Growth and damping of oblique electromagnetic ion cyclotron waves in the Earth's magnetosphere

The dispersive properties of oblique electromagnetic ion cyclotron (EMIC) waves are examined for conditions in the Earth's outer magnetosphere (L = 7) when the energetic particle distribution has a high-energy tail modeled by a generalized Lorentzian distribution. For small wave normal angles ψ to the ambient magnetic field, the wave growth and damping rates for a generalized Lorentzian distribution are smaller than those for a Maxwellian distribution (typically by a factor of 2), while for larger wave normal angles (ψ ≳ 60°) the corresponding differences in the growth and damping rates are relatively small. For both the generalized Lorentzian and Maxwellian distributions, maximum wave growth due to hot proton temperature anisotropy occurs for parallel propagation, but significant wave growth can occur for wave normal angles |ψ| ≲ 30°. Unstable waves produced near the magnetic equator are expected to be damped at higher latitudes as a result of cyclotron damping by thermal helium (He+) ions near the bi-ion frequency or near the second harmonic of the helium gyrofrequency. A new physical process identified in this study is the excitation of high-frequency oblique (ψ ∼ 50°–60°) EMIC waves due to second harmonic resonance with hot anisotropic protons. This leads to significant wave growth at frequencies above the maximum unstable frequency for parallel propagating waves.
Frequency shifts near an interface: inadequacy of two-level atomic models

In atoms a distance z from a perfectly conducting plane, electric dipole frequencies omega suffer shifts of order (d2)/z3 for small z, where d is the dipole operator. A totally different expression has been proposed recently, behaving like (d2) omega 3 log( omega z); it can emerge from some calculations on a two-level atomic model. One reason is an unrepresentative cancellation, peculiar to the model, between leading terms in the shifts of the two levels. A deeper failure of the model is its inconsistency with basic quantum mechanics, in that the upper level cannot obey the Thomas-Reiche-Kuhn sum rule, allowing results to depend on just how the calculation is performed.
A recent northern origin for the Uto-Aztecan family

Abstract:The Uto-Aztecan language family is one of the largest language families in the Americas. However, there has been considerable debate about its origin and how it spread. Here we use Bayesian phylogenetic methods to analyze lexical data from thirty-four Uto-Aztecan varieties and two Kiowa-Tanoan languages. We infer the age of Proto-Uto-Aztecan to be around 4,100 years (3,258–5,025 years) and identify the most likely homeland to be near what is now Southern California. We reconstruct the most probable subsistence strategy in the ancestral Uto-Aztecan society and infer no casual or intensive cultivation, an absence of cereal crops, and a primary subsistence mode of gathering (rather than agriculture). Our results therefore support the timing, geography, and cultural practices of a northern origin and are inconsistent with alternative scenarios.
Temporal variability in fine root dynamics in relation to tree girth size in sub‐tropical sal (Shorea robusta) forests

In forest ecosystems, the rapid turnover of fine roots (≤2 mm in diameter) is a major pathway of carbon and nutrient flow from plants to the soil. This study was conducted to determine how fine root biomass (FRB), productivity (FRP) and turnover (FRT) are affected by site characteristics, seasonal variation, soil depth and tree girth size in sub‐tropical sal forest ecosystem. Four sites (S1, S2, S3 and S4) were established in the Bhabhar region of Nainital istrict, Uttarakhand, India within an elevational range of 405 and 580 m, and at each site, sal trees were categorized into five girth classes. Fine roots were sampled seasonally up to a depth of 60 cm and divided into three layers (0–20, 20–40 and 40–60 cm). FRB was significantly affected by tree girth size and decreased with increasing girth size, while the effect of tree girth on FRP and FRT was observed to be insignificant. Seasonal variation of FRB in all girth sizes showed a keen resemblance as the standing FRB reached its pinnacle during the rainy season and the bottom line in the winter season. Maximum FRB was reported for the uppermost, organo‐mineral‐rich soil depth (0–20 cm) at 1.0 m distance from the tree bole and decreased with increasing soil depth and distance from the tree bole while FRT showed a reverse trend. The present study provided a holistic outlook on variations in FRB, FRP and FRT and the impact of edaphic characteristics and tree girth on fine root dynamics in the sal forest ecosystem of Central Himalaya, India.
A laser capture microdissection transcriptome of M. truncatula roots responding to rhizobia reveals spatiotemporal tissue expression patterns of genes involved in nodule signaling and organogenesis

We report a public resource for examining the spatiotemporal RNA expression of 54,893 M. truncatula genes during the first 72 hours of response to rhizobial inoculation. Using a methodology that allows synchronous inoculation and growth of over 100 plants in a single media container, we harvested the same segment of each root responding to rhizobia in the initial inoculation over a time course, collected individual tissues from these segments with laser capture microdissection, and created and sequenced RNA libraries generated from these tissues. We demonstrate the utility of the resource by examining the expression patterns of a set of genes induced very early in nodule signaling, as well as two gene families (CLE peptides and nodule specific PLAT-domain proteins) and show that despite similar whole root expression patterns, there are tissue differences in expression between the genes. Using a rhizobial response data set generated from transcriptomics on intact root segments, we also examined differential temporal expression patterns and determined that, after nodule tissue, the epidermis and cortical cells contained the most temporally patterned genes. We circumscribed gene lists for each time and tissue examined and developed an expression pattern visualization tool. Finally, we explored transcriptomic differences between the inner cortical cells that become nodules and those that do not, confirming that the expression of ACC synthases distinguishes inner cortical cells that become nodules and provide and describe potential downstream genes involved in early nodule cell division.
The impact of paramutations on the invasion dynamics of transposable elements

According to the prevailing view, the trap model, invading transposable elements (TEs) are stopped in their proliferation when a TE copy jumps into a piRNA cluster, which triggers the emergence of piRNAs that silence the TE. One crucial component in the host defence are paramutations. Mediated by maternally deposited piRNAs, paramutations convert TE insertions into piRNA producing loci, thereby transforming selfish TEs into agents of the host defence. Despite this significant effect, the impact of paramutations on the dynamics of TE invasions remains unknown. To address this issue, we performed extensive forward simulations of TE invasions with piRNA clusters and paramutations. We found that paramutations significantly affect TE dynamics, by accelerating the silencing of TE invasions, reducing the number of insertions accumulating during the invasions and mitigating the fitness cost of TEs. We also demonstrate that piRNA production induced by paramutations, an epigenetically inherited trait, may be positively selected. Finally, we show that paramutations may account for three important open problems with the trap model. Firstly, paramutated TE insertions may compensate for the insufficient number of insertions in piRNA clusters observed in previous studies. Secondly, paramutations may explain the discrepancy between the observed and the expected abundance of different TE families in D. melanogaster. Thirdly, paramutations render piRNA clusters dispensable once the host defence has been established, which may account for the lack of TE activation when three major piRNA clusters were deleted in a previous study.
PREMIX :A F ORTRAN Program for Modeling Steady Laminar One-Dimensional Premixed Flames

This report documents a Fortran computer program that computes species and temperature profiles in steady-state burner-stabilized and freely propagating premixed laminar flames. The program accounts for finite rate chemical kinetics and multicomponent molecular transport. After stating the appropriate governing equations and boundary conditions, we discuss the finite difference discretization and the Newton method for solving the boundary value problem. Global convergence of this algorithm is aided by invoking time integration procedures when the Newton method has convergence difficulties. The program runs in conjunction with preprocessors for the chemical reaction mechanism and the transport properties. Transport property formulations include the option of using multicomponent or mixtureaveraged formulas for molecular diffusion. Discussion of two example problems illustrates many of the program's capabilities.
The Novel Silver-Containing Antimicrobial Potentiates Aminoglycoside Activity Against Pseudomonas aeruginosa

The rapid dissemination of antibiotic resistance combined with the decline in the discovery of novel antibiotics represents a major challenge for infectious disease control that can only be mitigated by investments into novel treatment strategies. Alternative antimicrobials, including silver, have regained interest due to their diverse mechanisms of inhibiting microbial growth. One such example is AGXX®, a broad-spectrum silver containing antimicrobial that produces highly cytotoxic reactive oxygen species (ROS) to inflict extensive macromolecular damage. Due to connections identified between ROS production and antibiotic lethality, we hypothesized that AGXX® could potentially increase the activity of conventional antibiotics. Using the gram-negative pathogen Pseudomonas aeruginosa, we screened possible synergistic effects of AGXX® on several antibiotic classes. We found that the combination of AGXX® and aminoglycosides tested at sublethal concentrations led to a rapid exponential decrease in bacterial survival and restored sensitivity of a kanamycin-resistant strain. ROS production contributes significantly to the bactericidal effects of AGXX®/aminoglycoside treatments, which is dependent on oxygen availability and can be reduced by the addition of ROS scavengers. Additionally, P. aeruginosa strains deficient in ROS detoxifying/repair genes were more susceptible to AGXX®/aminoglycoside treatment. We further demonstrate that this synergistic interaction was associated with significant increase in outer and inner membrane permeability, resulting in increased antibiotic influx. Our study also revealed that AGXX®/aminoglycoside-mediated killing requires an active proton motive force across the bacterial membrane. Overall, our findings provide an understanding of cellular targets that could be inhibited to increase the activity of conventional antimicrobials. IMPORTANCE The emergence of drug-resistant bacteria coupled with the decline in antibiotic development highlights the need for novel alternatives. Thus, new strategies aimed at repurposing conventional antibiotics have gained significant interest. The necessity of these interventions is evident especially in gram-negative pathogens as they are particularly difficult to treat due to their outer membrane. This study highlights the effectiveness of the silver containing antimicrobial AGXX® in potentiating aminoglycoside activities against P. aeruginosa. The combination of AGXX® and aminoglycosides not only reduces bacterial survival rapidly but also significantly re-sensitizes aminoglycoside-resistant P. aeruginosa strains. In combination with gentamicin, AGXX® induces increased endogenous oxidative stress, membrane damage and iron sulfur cluster disruption. These findings emphasize AGXX®’s potential as a route of antibiotic adjuvant development and shed light into potential targets to enhance aminoglycoside activity.