Miracle-dz/UniFAR-FTUs huggingface dataset:
Cannabinoid and Serotonergic Systems: Unraveling the Pathogenetic Mechanisms of Stress-Induced Analgesia

The perception of „stress” triggers many physiological and behavioral responses, collectively called the stress response. Such a complex process allows for coping with stress and also triggers severe pathology. Because of the multidirectional effect of stress on the body, multiple systems participate in its pathogenesis, with the endogenous cannabinoid and the serotoninergic ones among them. These two systems also take part in the pain perception decrease, known as stress-induced analgesia (SIA), which can then be taken as an indirect indicator of the stress response. The aim of our study was to study the changes in cold SIA (c-SIA) resulting from the exogenous activation of cannabinoid receptor type 1 (CB1) and 5-hydroxytryptamine (5-HT, serotonin) receptor type 1A (5-HT1A). Various combinations of agonists and/or antagonists of CB1 and 5-HT1A, before or after 1 h of cold exposure, were applied, since we presumed that the exogenous activation of the receptors before the cold exposure would influence the pathogenesis of the stress response, while their activation after the stressful trigger would influence the later development. Our results show that the serotonergic system “maintained” c-SIA in the pre-stress treatment, while the cannabinoids’ modulative effect was more prominent in the post-stress treatment. Here, we show the interactions of the two systems in the stress response. The interpretation and understanding of the mechanisms of interaction between CB1 and 5-HT1A may provide information for the prevention and control of adverse stress effects, as well as suggest interesting directions for the development of targeted interventions for the control of specific body responses.
Social Capital's Mediation in Compensation Workers' Financial to Personal Well-being in CALABARZON, Philippines

Growing concerns over personal financial vulnerability have prompted developed nations to enhance financial well-being, a crucial aspect linked to overall individual welfare. This research focuses on evaluating the interplay between financial well-being (FWB) and personal well-being (PWB) among workers in the Philippines, while also examining the impact of social capital (SC) on this relationship. Collecting 196 responses from CALABARZON compensation workers through standardized questionnaires, the study addresses limitations in prior research. Employing PLS-SEM analysis, the findings reveal moderate FWB and SC scores with a high level of PWB. Validating well-being and social capital theories, the study identifies a positive correlation between FWB and PWB, and a significant effect of FWB on SC. However, mediation analysis suggests that SC only partially complements the FWB-PWB relationship, hinting at potential mediators beyond SC. This comprehensive model not only provides enhanced insights into employees' well-being but also aids in identifying those in need of assistance, determining training or intervention needs, and evaluating treatment outcomes. Crucially, it emphasizes that improving FWB doesn't necessarily result in significant economic costs for employers.
TVRI Yogyakarta in the era of disruption: Maintaining the existence of cultural wisdom through the broadcast of "Canthing

The existence of social media, which intensively displays similarities with television shows, has resulted in the decline of the television industry. Thus shifting the tastes of the younger generation by offering modern trends rather than local culture. This also happened on local Republic of Indonesia television, such as TVRI Yogyakarta. This article aims to reveal TVRI Yogyakarta's strategy for maintaining cultural wisdom through the Canthing program amid an era of media disruption. Data was obtained through observation, interviews, and documentation related to research. The results of this research show that TVRI Yogyakarta's strategy in maintaining the existence of the Canthing program is through the use of professional human resources, packaging the program with the main content of Javanese culture, methods of approaching and involving the youth community and socializing the program through advertisements on various TVRI Yogyakarta programs. by using social media as a form of divergence, convergence, and cyclone methods. TVRI Yogyakarta tries to provide innovations in the programs presented according to current developments so that they continue to be in demand by the current generation and beyond. This study contributes to the development of theories and concepts of the function of media as a cultural medium, which is also the orientation of Islamic communication. ***Eksisnya media sosial yang gencar menampilkan kemiripan dengan tayangan televisi mengakibatkan menurunnya industri pertelevisian sehingga menggeser selera generasi muda dengan penawaran trend modern daripada budaya lokalnya. Hal tersebut juga terjadi di televisi lokal Republik Indonesia seperti TVRI Yogyakarta. Tulisan ini bertujuan untuk membongkar bagaimana strategi TVRI Yogyakarta dalam menjaga eksistensi kearifan budaya di tengah era disrupsi media melalui program Canthing. Data diperoleh melalui observasi, wawancara, dan dokumentasi yang terkait dengan penelitian. Hasil dari penelitian ini diperoleh bahwa strategi TVRI Yogyakarta dalam mempertahankan eksistensi program Canthing melalui penggunaan sumber daya manusia yang profesional, pengemasan program dengan mengusung konten utama budaya Jawa, metode pendekatan dengan melibatkan komunitas anak muda, dan sosialisasi program melalui iklan pada berbagai program acara TVRI Yogyakarta dengan pemanfaatan media social sebagai bentuk dari metode divergensi, konvergensi, dan siklon. TVRI Yogyakarta berusaha memberikan inovasi baru terhadap program-program yang disajikan sesuai perkembangan zaman sehingga terus diminati oleh generasi masa kini dan seterusnya. Studi ini berkontribusi bagi pengembangan teori dan konsep fungsi media sebagai sarana kebudayaan, yang juga menjadi orientasi dari komunikasi Islam.
Growth and yield of okra (Abelmoschus esculentus L.) as influenced by NPK, jatropha cake and organomineral fertiliser on an Alfisol in Ilorin, southern Guinea Savanna of Nigeria.

A field experiment was conducted at Kwara State University, Malete, Ilorin, Nigeria during 2013 growing seasons to study the growth and yield of okra (Abelmoschus esculentus) as influenced by NPK, jatropha cake and organomineral fertiliser on an Alfisol in Ilorin. The four treatments tested were; control, NPK, jatropha cake and organomineral fertiliser. The treatments were replicated three times in a randomised complete block design. Each treatment was applied at 100kg N/ha. The experiment lasted for over three month crop cycles. The parameters assessed were significantly influenced (p<0.05) by the applied fertilisers. Results of the experiment indicated that applications of organomineral Grade A fertiliser significantly (p< 0.05) increased plant height, stem girth, number of leaves, number of flower per plant, fruit weight and fruit yield as compared to NPK, jatropha cake and control. Okra fruit weight values obtained from organomineral Grade A, NPK and jatropha cake were 235.3, 207.7 and 157.7g respectively. Fruit yield values obtained from organomineral Grade A (6.53 t/ha) was also significantly (p< 0.05) higher than that of NPK values (5.75 t/ha). Although mineral fertiliser is cost effective, it is difficult to procure and cannot substantially redress the physical fragility of the soil. However, organomineral Grade A and jatropha cake are cheap, readily available and environmentally friendly as fertilizers. In conclusion, this study showed that organomineral Grade A applied at 100 kg N/ha could be effectively used as alternative to mineral fertiliser in growing okra on an Alfisol of Ilorin, Nigeria.
Explaining occurrences of auroral kilometric radiation in Van Allen radiation belts

Auroral kilometric radiation (AKR) is a strong terrestrial radio emission and dominates at higher latitudes because of reflection in vicinities of the source cavity and plasmapause. Recently, Van Allen Probes have observed occurrences of AKR emission in the equatorial region of Earth's radiation belts but its origin still remains an open question. Equatorial AKR can produce efficient acceleration of radiation belt electrons and is a risk to space weather. Here we report high‐resolution observations during two small storm periods 4–6 April and 18–20 May 2013 and show, using a 3‐D ray tracing simulation, that AKR can propagate downward all the way into the equatorial plane in the radiation belts under appropriate conditions. The simulated results can successfully explain the observed AKR's spatial distribution and frequency range, and the current results have a wide application to all other magnetized astrophysical objects in the universe.
Subacute Thyroiditis in Active COVID-19 Infection: A Report of Two Cases With a Systematic Review of the Literature

Subacute thyroiditis (SAT) is a self-limiting inflammatory condition of the thyroid gland with distinct symptoms and a predictable outcome. During the current COVID-19 pandemic, there have been multiple isolated reports of SAT either during the active viral illness or following recovery. Here, we report two such cases of COVID-19 infection presenting with SAT. A 65-year-old male presented with a two-week history of anterior neck pain, odynophagia, high-grade fever (38.9°C), sweating, palpitations, and tremulousness. At physical examination, the patient presented with a slightly increased heart rate and a tender and enlarged thyroid on palpation. Laboratory examination showed high C-reactive protein levels, with elevated erythrocyte sedimentation rate, and thyroid function tests were suggestive of thyrotoxicosis. Ultrasonography showed a heterogeneous thyroid gland with ill-defined hypoechoic areas, and thyroid scintigraphy showed reduced uptake, confirming the diagnosis of SAT. In another case, a 52-year-old male presented with fever, cough, and myalgias, and was diagnosed with mild COVID-19 pneumonia, and managed conservatively. After two weeks, the patient had a recurrence of high-grade fever, odynophagia, palpitations, and tremors. Examination revealed tachycardia, hyperhidrosis, and a tender and enlarged thyroid on palpation. Thyroid function tests revealed low thyroid-stimulating hormone, with normal total T4 and total T3. Ultrasonography examination showed a heterogeneous thyroid gland with bilateral ill-defined hypoechoic areas. In our systematic review, including 103 SAT cases, it has been suggested that SAT should be recognized as an uncommon extra-pulmonary clinical manifestation of COVID-19 infection and clinicians need to be aware of the association. Pending larger multicentric studies, management of the condition has to be on a case-by-case basis.
Determination of formation specific NMR calibrations for water well evaluation in a semi-consolidated aquifer

Downhole NMR data was collected through a fibreglass cased section of water well NG3A that intersected the semi-consolidated sediments of the Yaragadee Formation which is one of the main aquifers supplying domestic water for the city of Perth. The main purpose of this work was to empirically derive formation specific NMR processing parameters to match the hydraulic property estimates to a direct core measurements, to calibrate the system to deliver a more detailed log of porosity and permeability in the hole as well as other holes logged in a similar geologic environment. Equations for NMR permeability estimation generally include lithology specific calibration coefficients. We show that application of “generic” calibration coefficients derived for unconsolidated aquifer materials overestimate permeability in the Yaragadee Formation when compared to core permeability measurements. This result is expected given that the Yaragadee formation is not unconsolidated but is partially consolidated/cemented. More appropriate site specific coefficients were derived by scaling the calibration coefficients to produce NMR permeability estimates that match the measurements derived from the core samples. The site specific coefficients determined for the Yaragadee are consistent with those derived in previous studies for partially consolidated aquifers in the United States. The NMR T2 distribution is very sensitive to pore size changes which often reflect subtle changes in the sedimentary geology of the formation. This can provide additional geological information which may not always be apparent in mud or core logging. Detailed knowledge of both the sedimentary geology as well as the hydraulic properties of the formation that can be obtained by NMR are likely to be useful in identifying the best place to place screens during the design of a production water well to generate the best possible yield.
Ranking the strongest ENSO events while incorporating SST uncertainty

The strength of El Niño–Southern Oscillation (ENSO) is often measured using a single, discrete value of the Niño index. However, this method does not consider the sea surface temperature (SST) uncertainty associated with the observations and data processing. On the basis of the Niño3. 4 index and its uncertainty, we find that the strength of the three strongest ENSO events is not separable at 95% confidence level. The monthly peak SST anomalies in the most recent 2015–2016 El Niño is tied with 1997–1998 and 1982–1983 El Niño as the strongest. The three most negative monthly Niño values occur within the 1955–1956, 1973–1974, and 1975–1976 La Niña events, which cannot be discriminated by rank. The histograms of 1000‐member ensemble analysis support the conclusion that the strength of the three strongest ENSO events is not separable. These results highlight that the ENSO ranking has to include the SST uncertainty.
Early impacts of the Pennsylvania Rural Health Model on potentially avoidable utilization

Abstract The Pennsylvania Rural Health Model (PARHM) is a novel alternative payment model for rural hospitals that aims to test whether hospital-based global budgets, coupled with delivery transformation plans, improve the quality of health care and health outcomes in rural communities. Eighteen hospitals joined PARHM in 3 cohorts between 2019 and 2021. This study assessed PARHM’s impact on changes in potentially avoidable utilization (PAU)—a measure of admission rates policymakers explicitly targeted for improvement in PARHM. Using a difference-in-differences analysis and all-payer hospital discharge data for Pennsylvania hospitals from 2016 through 2022, we found no significant overall reduction in community-level PAU rates up to 4 years post–PARHM implementation, relative to changes in rural Pennsylvania communities whose hospitals did not join PARHM. However, heterogeneous treatment effects were observed across cohorts that joined PARHM in different years, and between critical access vs prospective payment system hospitals. These findings offer insight into how alternative payment models in rural health care settings may have heterogeneous impacts based on contextual factors and highlight the importance of accounting for these factors in proposed expansions of alternative payment models for rural health systems.
Running Toward Equity: Socioeconomic Diversity and Parental Perception of a Physical Activity-Based Positive Youth Development Program for Girls

The Girls on the Run (GOTR) is a national positive youth development program to promote self-confidence, resilience, and self-esteem for girls through physical activity. It also includes an opportunity for parental support through involvement in a 5K event at the end of the program. There is significant evidence on the importance of family support and parent role modeling for children’s physical activity, but little is known on how children can encourage adult physical activity. This study aimed to explore parents’ perceptions of their daughters’ participation in GOTR, and their attitudes toward physical activity while exploring variations in these perceptions between parents in different socioeconomic groups. Parents were recruited from high and low-resource sites for participation in online focus group discussions. Questions included perspectives on their daughter’s participation in GOTR, their physical activity, and participation in the GOTR 5K event. Discussions were recorded, transcribed, and thematically analyzed from two focus groups with parents from low-resource sites (N=10) and two with parents from high-resource sites (N= 15). A common theme across resource groups was that GOTR enhances self-confidence, communication skills, and physical activity. More parents from the high-resource sites reported being physically active and having supportive environments than parents from low-resource sites. While some parents noted the intention to participate in the 5K with their daughter, more parents in the low-resource group reported barriers to physical activity and participation in the 5K event. There is an opportunity to encourage and facilitate parental 5K participation to create a ripple effect for the benefits of the GOTR program.
Framework development for transforming multistakeholder value into prioritized business processes improvement in Higher Education Institutions (HEI)

Purpose: This article seeks to develope framework of multistakeholder value transformation into an business process improvement plan in Higher Education Institutions (HEI). Design/methodology/approach: multistakeholder value and its importance weight are obtained through questionnaires and fuzzy method. Transformation of multistakeholder value into priority business process improvement using an expert panel, adopting Quality Function Development (QFD) and House of Risk (HOR). Findings: This research has developed a framework consisting of two parts: the framework to transform the multistakeholder value into an HEI business process and the framework to determine the priority of improvements. The framework was successfully applied in a private university to find and prioritize business process improvement.Research limitations/implications: The stakeholders used in this framework are students, lecturers, and employers. The results of this study are the order of priority for improving business processes. The next research opportunity is to develop a business process improvement selection model considering the probability of success, priorities, and costs. Another possibility of research is to involve other stakeholders.Originality/value: Previous research on the identification of stakeholder value HEI only involved one of the stakeholders. In addition, most of the objectives were to assess the level of importance and satisfaction of stakeholders. This research develops a framework to identify multistakeholder values (students, lecturers, and employers) and transform them into a business process improvement plan consisting of teaching, research and community service, student affairs, and supporting activities.
Upward and Downward Inclination Hydraulic Capsule Pipeline

The effect of upward (+7.5 °, +15°) and downward (-7.5° & 15°) hydraulic capsule pipe (HCP) inclinations on the capsule lift-off velocity, capsule to water velocity ratio, and pressure gradient was investigated experimentally. Experiments were conducted for water velocities between 0.5 and 4.0 m/s and capsule material specific gravity between 1.5 and 3.5. The investigations were performed using 6 m long ,50 mm ID Plexy-glass pipe . High-speed video recording and calibrated turbine flow meter were used to precisely identify the capsule lift-off velocity and capsule velocity. Data for both positive and negative inclinations were compared to horizontal position. It was found that the capsule to water velocity ratio increases as water velocity and corresponding Reynolds number increases, also it is higher for the downward than for the upward flows. At certain water velocity the velocity ratio increased with negative pipe inclination while it decreased at positive inclinations and increased capsule specific gravity. The frictional pressure gradient in upward flows was in general higher than in horizontal flows while a lower pressure gradient occurred at downward flows at lower capsule specific gravity and Reynolds number, i.e. lower water flow velocity.
Management of Refractory Post-operative Osteomyelitis and Discitis: A Case Report

Vertebral osteomyelitis/discitis is a relatively rare disease but is a known potential complication of spinal surgical intervention. In general, the first-line treatment for this condition is targeted antibiotic therapy with surgical intervention only utilized in refractory cases with evidence of extensive damage, structural instability, or abscess formation. However, surgical best practices have not been established for osteomyelitis, including indications for anterior lateral interbody fusion (ALIF), posterior lateral interbody fusion (PLIF), or direct lateral interbody fusion (DLIF). This case provides a discussion of the indications that led to a direct lateral approach in the setting of refractory osteomyelitis/discitis, supporting factors that led to its success, and the efficacy of utilizing intraoperative neuromonitoring in cases of infection.
Cystatin C or creatinine for pre-operative assessment of kidney function and risk of post-operative acute kidney injury: a secondary analysis of the METS cohort study

ABSTRACT Background Post-operative acute kidney injury (PO-AKI) is a common surgical complication consistently associated with subsequent morbidity and mortality. Prior kidney dysfunction is a major risk factor for PO-AKI, however it is unclear whether serum creatinine, the conventional kidney function marker, is optimal in this population. Serum cystatin C is a kidney function marker less affected by body composition and might provide better prognostic information in surgical patients. Methods This was a pre-defined, secondary analysis of a multi-centre prospective cohort study of pre-operative functional capacity. Participants were aged ≥40 years, undergoing non-cardiac surgery. We assessed the association of pre-operative estimated glomerular filtration rate (eGFR) calculated using both serum creatinine and serum cystatin C with PO-AKI within 3 days after surgery, defined by KDIGO creatinine changes. The adjusted analysis accounted for established AKI risk factors. Results A total of 1347 participants were included (median age 65 years, interquartile range 56–71), of whom 775 (58%) were male. A total of 82/1347 (6%) patients developed PO-AKI. These patients were older, had higher prevalence of cardiovascular disease and related medication, were more likely to have intra-abdominal procedures, had more intraoperative transfusion, and were more likely to be dead at 1 year after surgery 6/82 (7.3%) vs 33/1265 (2.7%) (P = .038). Pre-operative eGFR was lower in AKI than non-AKI patients using both creatinine and cystatin C. When both measurements were considered in a single age- and sex-adjusted model, eGFR-Cysc was strongly associated with PO-AKI, with increasing risk of AKI as eGFR-Cysc decreased below 90, while eGFR-Cr was no longer significantly associated. Conclusions Data from over 1000 prospectively recruited surgical patients confirms pre-operative kidney function as major risk factor for PO-AKI. Of the kidney function markers available, compared with creatinine, cystatin C had greater strength of association with PO-AKI and merits further assessment in pre-operative assessment of surgical risk.