Miracle-dz/UniFAR-FTUs huggingface dataset:
The Effect of Ocimum basilicum L. and Its Main Ingredients on Respiratory Disorders: An Experimental, Preclinical, and Clinical Review

Ocimum basilicum L. (O. basilicum) and its constituents show anti-inflammatory, immunomodulatory, and antioxidant effects. The plant has been mainly utilized in traditional medicine for the treatment of respiratory disorders. In the present article, effects of O. basilicum and its main constituents on respiratory disorders, assessed by experimental and clinical studies, were reviewed. Relevant studies were searched in PubMed, Science Direct, Medline, and Embase databases using relevant keywords including “Ocimum basilicum,” “basilicums,” “linalool,” “respiratory disease,” “asthma,” “obstructive pulmonary disease,” “bronchodilatory,” “bronchitis,” “lung cancer,” and “pulmonary fibrosis,” and other related keywords.The reviewed articles showed both relieving and preventing effects of the plant and its ingredients on obstructive pulmonary diseases such as chronic obstructive pulmonary disease (COPD), asthma, and other respiratory disorders such as bronchitis, aspergillosis tuberculosis, and lung cancer. The results of the reviewed articles suggest the therapeutic potential of O. basilicum and its constituent, linalool, on respiratory disorders.
B Cell Receptor Signaling and Protein Kinase D2 Support Regulatory B Cell Function in Pancreatic Cancer

B cells can act as potent suppressors of anti-tumor T cell immunity, presenting a mechanism of resistance to immunotherapy. In pancreatic ductal adenocarcinoma, B cells can display a T cell-suppressive or regulatory phenotype centered on the expression of the cytokine Interleukin 35 (IL-35). While B cell-mediated immunosuppression presents a barrier to anti-tumorigenic T cell function, it is not clear how regulatory B cell function could be targeted, and the signals that promote this suppressive phenotype in B cells are not well understood. Here we use a novel IL-35 reporter model to understand which signaling pathways are important for immunosuppressive properties in B cells. In vitro analysis of IL-35 reporter B cells revealed a synergy between the BCR and TLR4 signaling pathways is sufficient to induce IL-35 expression. However, in vivo, B cell receptor activation, as opposed to MyD88 signaling in B cells, is central to B cell-mediated suppression and promotion of pancreatic cancer growth. Further analysis identified protein kinase D2 (PKD2) as being a key downstream regulator of IL-35 expression in B cells. Regulatory B cells with an inactivating mutation in PKD2 failed to produce IL-35 or fully suppress effector T cell function in vitro. Furthermore, inhibition of PKD in B cells decreased tumor growth and promoted effector T cell function upon adoptive transfer into B cell-deficient mice. Collectively, these data provide insight into how regulatory B cell function is promoted in pancreatic cancer and identify potential therapeutic targets to restrain this function.
The Central Dark Matter Fraction of Massive Early-Type Galaxies

Dark matter (DM) is predicted to be the dominant mass component in galaxies. In the central region of early-type galaxies it is expected to account for a large amount of the total mass, although the stellar mass should still represent the majority of the mass budget, depending on the stellar initial mass function (IMF). We discuss latest results on the DM fraction and mean DM density for local galaxies and explore their evolution with redshifts in the last 8 Gyr of the cosmic history. We compare these results with expectations from the ΛCDM model and discuss the role of the IMF and galaxy model through the central total mass density slope. We finally present future perspectives offered by next-generation instruments/surveys (Rubin/LSST, Euclid, CSST, WEAVE, 4MOST, and DESI), which will provide the unique chance to measure the DM evolution with time for an unprecedented number of galaxies and constrain their evolutionary scenario.
Manipulation of Barley Development and Flowering Time by Exogenous Application of Plant Growth Regulators

Matching flowering time to the optimal flowering period in Mediterranean cropping zones is pivotal to maximize yield. Aside from variety selection and sowing date, growers have limited options to alter development in season. Plant hormones and growth regulators are used in perennial horticultural systems to manipulate development and floral initiation. In this study, a range of plant hormonal products were tested to analyze their effects on barley (Hordeum vulgare L) development by exogenous spray applications. Plants were grown in controlled conditions under long and short photoperiods with different vernalization treatments. The gibberellin (GA) products demonstrated the greatest potential for altering development. The GA inhibitor trinexapac-ethyl was able to delay the time to flowering in genetically divergent barley cultivars by up to 200 degree days under controlled conditions. A similar delay in flowering could be achieved via application at both early (GS13) and late (GS33) stages, with higher rates delaying flowering further. Notably, trinexapac-ethyl was able to extend the duration of pre-anthesis phases of development. By contrast, GA3 was unable to accelerate development under extreme short (8 h) or long (16 h) day lengths. There was also little evidence that GA3 could reproducibly accelerate development under intermediate 10–12 h day lengths. In addition, sprays of the cytokinin 6-benzyladenine (6-BA) were unable to reduce the vernalization requirement of the winter genotype Urambie. The present study provides baseline data for plant growth regulator treatments that delay cereal development. These treatments might be extended in field studies to align flowering of early sown crops to the optimal flowering period.
Brenda Milner: Pioneer of the Study of the Human Frontal Lobes

Although the behavioral effects of damage to the frontal lobes date back to at least the late 19th century even midway through the 20th century very little was known about human frontal lobe function and there was a general consensus that the frontal lobe did not play a key role in cognition. This all changed when Brenda Milner published a chapter in a 1964 volume entitled: The Frontal Granular Cortex and Behavior. Milner’s chapter, “Some effects of frontal lobectomy in man,” was the first systematic study of the effect of frontal lobe excisions on cognition in human patients. Milner had access to a unique population of frontal excision patients at the Montreal Neurological Institute that were being treated by Wilder Penfield and his associates for a wide range of neurological disorders, including intractable epilepsy. Milner and her colleagues engaged in a more than 50-year study that has had a formidable impact on our understanding of frontal lobe function. Paralleling studies of frontal lobe function in non-humans they influence on understanding the evolution and function of the prefrontal cortex of mammals. Thus, although Brenda Milner is best known for her studies of human memory, she has had an equally important contribution to our understanding of the frontal lobes.
A Review on the Role of miR-1246 in the Pathoetiology of Different Cancers

miR-1246 is a microRNA firstly recognized through application of a high throughput sequencing technique in human embryonic stem cells. Subsequent studies have shown the role of this microRNA in the carcinogenesis. miR-1246 has been found to exert oncogenic roles in colorectal, breast, renal, oral, laryngeal, pancreatic and ovarian cancers as well as melanoma and glioma. In lung, cervical and liver cancers, studies have reported contradictory results regarding the role of miR-1246. miR-1246 has been reported to regulate activity of RAF/MEK/ERK, GSK3β, Wnt/β-catenin, JAK/STAT, PI3K/AKT, THBS2/MMP and NOTCH2 pathways. In addition to affecting cell cycle progression and proliferation, miR-1246 can influence stemness and resistance of cancer cells to therapeutics. In the current review, we describe the summary of in vitro and in vivo studies about the influence of miR-1246 in carcinogenesis in addition to studies that measured expression levels of miR-1246 in clinical samples.
Effects of Titanium Dioxide Nanoparticles on Porcine Prepubertal Sertoli Cells: An “In Vitro” Study

The increasing use of nanomaterials in a variety of industrial, commercial, medical products, and their environmental spreading has raised concerns regarding their potential toxicity on human health. Titanium dioxide nanoparticles (TiO2 NPs) represent one of the most commonly used nanoparticles. Emerging evidence suggested that exposure to TiO2 NPs induced reproductive toxicity in male animals. In this in vitro study, porcine prepubertal Sertoli cells (SCs) have undergone acute (24 h) and chronic (from 1 up to 3 weeks) exposures at both subtoxic (5 µg/ml) and toxic (100 µg/ml) doses of TiO2 NPs. After performing synthesis and characterization of nanoparticles, we focused on SCs morphological/ultrastructural analysis, apoptosis, and functionality (AMH, inhibin B), ROS production and oxidative DNA damage, gene expression of antioxidant enzymes, proinflammatory/immunomodulatory cytokines, and MAPK kinase signaling pathway. We found that 5 µg/ml TiO2 NPs did not induce substantial morphological changes overtime, but ultrastructural alterations appeared at the third week. Conversely, SCs exposed to 100 µg/ml TiO2 NPs throughout the whole experiment showed morphological and ultrastructural modifications. TiO2 NPs exposure, at each concentration, induced the activation of caspase-3 at the first and second week. AMH and inhibin B gene expression significantly decreased up to the third week at both concentrations of nanoparticles. The toxic dose of TiO2 NPs induced a marked increase of intracellular ROS and DNA damage at all exposure times. At both concentrations, the increased gene expression of antioxidant enzymes such as SOD and HO-1 was observed whereas, at the toxic dose, a clear proinflammatory stress was evaluated along with the steady increase in the gene expression of IL-1α and IL-6. At both concentrations, an increased phosphorylation ratio of p-ERK1/2 was observed up to the second week followed by the increased phosphorylation ratio of p-NF-kB in the chronic exposure. Although in vitro, this pilot study highlights the adverse effects even of subtoxic dose of TiO2 NPs on porcine prepubertal SCs functionality and viability and, more importantly, set the basis for further in vivo studies, especially in chronic exposure at subtoxic dose of TiO2 NPs, a condition closer to the human exposure to this nanoagent.
Brain Imaging Biomarkers for Chronic Pain

The prevalence of chronic pain has reached epidemic levels. In addition to personal suffering chronic pain is associated with psychiatric and medical co-morbidities, notably substance misuse, and a huge a societal cost amounting to hundreds of billions of dollars annually in medical cost, lost wages, and productivity. Chronic pain does not have a cure or quantitative diagnostic or prognostic tools. In this manuscript we provide evidence that this situation is about to change. We first start by summarizing our current understanding of the role of the brain in the pathogenesis of chronic pain. We particularly focus on the concept of learning in the emergence of chronic pain, and the implication of the limbic brain circuitry and dopaminergic signaling, which underly emotional learning and decision making, in this process. Next, we summarize data from our labs and from other groups on the latest brain imaging findings in different chronic pain conditions focusing on results with significant potential for translation into clinical applications. The gaps in the study of chronic pain and brain imaging are highlighted in throughout the overview. Finally, we conclude by discussing the costs and benefits of using brain biomarkers of chronic pain and compare to other potential markers.
Higher Yogurt Consumption Is Associated With Lower Risk of Colorectal Cancer: A Systematic Review and Meta-Analysis of Observational Studies

Background: Yogurt is known to be nutrient-rich and probiotic content, which gather optimism due to their potential role in preventing and managing cancers. The effect of yogurt consumption on colorectal cancer (CRC) is inconsistent. Objective: This study aims to investigate the association of yogurt consumption with the risk of CRC. Methods: Three databases, namely, PubMed, Web of Science, and Embase, were searched for all relevant studies from July 2021 on the association of yogurt consumption with CRC risk. We pooled the odds ratios (ORs) and their 95% CIs using a random-effects meta-analysis to assess the association. Results: Finally, 16 studies met the inclusion criteria and were chosen in the meta-analysis. Yogurt consumption was significant with lower risk of CRC risk in the overall comparison (OR = 0.87, 95% CI: 0.81–0.94), in the cohort studies (OR = 0.91, 95% CI: 0.86–0.97), and case-control studies (OR = 0.75, 95% CI: 0.65–0.85). With regard to subgroup analyses by study region, cancer type, publication year, and sex, yogurt consumption significantly decreased overall CRC, colon cancer, and distal colon cancer risks. In stratified analyses, we observed significantly decreased CRC risk in Europe and Africa and published after 2010 and overall population. Sensitivity analysis indicated the result is stable and there is no publication bias in the meta-analysis. Conclusions: Overall, this study indicated that yogurt intake was related to a decreased risk of CRC.
Clinical Characteristics of 10 Pregnant and Postpartum Women With Extracorporeal Membrane Oxygenation: A Retrospective Study

Background: The aim of study was to summarize the clinical characteristics and experience of extracorporeal membrane oxygenation (ECMO) in pregnant and postpartum patients. Methods and Results: We retrospectively reviewed 131 consecutive ECMO patients at our center from May 2015 to May 2021. A total of 10 Chinese patients were pregnant or postpartum at the time of ECMO initiation. Patients ranged in age from 25 to 36 years (median age 30.5 years). The ECMO duration ranged from 3 to 31 days (median duration 8 days). There was a stabilizing trend of acid-base balance and decreasing lactic acid over the 3 days following ECMO initiation. Seven (70%) patients survived at least 48 h after weaning from ECMO. Four (40%) patients survived until discharge, and four (40%) fetuses survived until discharge. Conclusion: ECMO provides a suitable temporary cardiopulmonary support for pregnant and postpartum patients. ECMO shows a favorable effect on short-term stability in critical obstetric patients.
Prognosis Between ST-Elevation and Non-ST-elevation Myocardial Infarction in Older Adult Patients

Background: Whether there is a difference in prognosis between elderly patients with ST-elevation myocardial infarction (STEMI) and non-ST-elevation myocardial infarction (NSTEMI) remains mysterious. Methods: We conducted a retrospective cohort study by analyzing the data in the Longitudinal Health Insurance Database (LHID) in Taiwan to explore differences between STEMI and NSTEMI with respect to in-hospital and long-term (3-year) outcomes among older adult patients (aged ≥65 years). Patients were further stratified based on whether they received coronary revascularization. Results: In total, 5,902 patients aged ≥65 years with acute myocardial infarction (AMI) who underwent revascularization (2,254) or medical therapy alone (3,648) were included. In the revascularized group, no difference was observed in cardiovascular (CV) and all-cause mortality during hospitalization or at 3-year follow-up between the two AMIs. Conversely, in the non-revascularized group, patients with NSTEMI had higher crude odds ratio (cOR) for all-cause death during hospitalization [cOR: 1.33, 95% confidence interval (CI) = 1.07–1.65] and at 3-year follow-up (cOR: 1.47, 95% CI = 1.21–1.91) relative to patients with STEMI. However, after multivariable adjustments, only NSTEMI indicated fewer in-hospital CV death [adjusted odds ratio (aOR): 0.75, 95% CI = 0.58–0.98] than STEMI in non-revascularized group. Moreover, major bleeding was not different between patients with STEMI or NSTEMI aged ≥65 years old. Conclusion: Classification of AMI is not associated with the difference of in-hospital or 3-year CV and all-cause death in older adult patients received revascularization. In a 3-year follow-up period, STEMI was an independent predictor of a higher incidence of revascularization after the index event. Non-ST-elevation myocardial infarction had more incidence of MACE than patients with STEMI did in both treatment groups.
Cortical encoding during word reading in bilinguals: parallel interdigitated distributed networks support convergent linguistic functioning

Word reading includes a series of cognitive processes that convert low-level visual characteristics to neural representations. However, the consistency of the neural mechanisms for processing these cognitive components across different writing systems in bilinguals remains inconclusive. Here, we explored this question by employing representational similarity analysis with a semantic access task involving Chinese words, English words and Chinese pinyin. Distinct anatomical distribution patterns were detected for each type of brain representation across ideographic and alphabetic languages, resulting in 100% classification accuracy. Meanwhile, convergent cognitive components processing was found in the core language-related regions in left hemisphere, including the inferior frontal gyrus, temporal pole, superior and middle temporal gyrus, precentral gyrus and supplementary motor areas. Broadly, our findings indicated that the neural basis for word recognition of different writing systems in bilinguals was divergent in anatomical locations of neural representations for specialized processing but convergent in cognitive domains, which supported and enriched the assimilation-accommodation hypothesis.
Impact of Iterative Reconstruction Algorithms on Image Quality and Radiation Dose in Computed Tomography Scan of Patients with Malignant Pancreatic Lesions

Background: The objective of this study was to investigate the influence of iterative reconstruction (IR) algorithm on radiation dose and image quality of computed tomography (CT) scans of patients with malignant pancreatic lesions by designing a new protocol. Methods: The pancreas CT was performed on 40 patients (23 males and 17 females) with a 160-slice CT scan machine. The pancreatic parenchymal phase was performed in two stages: one with a usual dose of radiation and the other one after using a reduced dose of radiation. The images obtained with usual dose were reconstructed with Filtered Back Projection (FBP) method (Protocol A); and the images obtained with the reduced dose were reconstructed with both FBP (Protocol B) and IR method (Protocol C). The quality of images and radiation dose were compared among the three protocols. Results: Image noise was significantly lower with Protocol C (10.80) than with Protocol A (14.98) and Protocol B (20.60) (P < 0.001). Signal-to-noise ratio and contrast-to-noise ratio were significantly higher with Protocol C than with Protocol A and Protocol B (P < 0.001). Protocol A and Protocol C were not significantly different in terms of image quality scores. Effective dose was reduced by approximately 48% in Protocol C compared with Protocol A (1.20 ± 0.53 mSv vs. 2.33 ± 0.86 mSv, P < 0.001). Conclusion: Results of this study showed that applying the IR method compared to the FBP method can improve objective image quality, maintain subjective image quality, and reduce the radiation dose of the patients undergo pancreas CT.
High voltage module with low internal inductance for next chip generation - next High Power Density Dual (nHPD2)

In order to obtain the full benefit of Wide Band Gap (WBG) semiconductor device, it is essential to reduce total system stray inductance. Hitachi's latest package technology development is the new high voltage package concept named "next High Power Density Dual (nHPD2)". The package offers not only a drastic reduction in the internal inductance by 75% from conventional modules, but also an increase in the power density compared with the latest F-version series modules. Hitachi formerly presented the latest generation F-series modules in 2014, showing a 20% higher power density compared to conventional devices in the market. nHPD2 provides even higher power densities, up to 10% more. The developed package is equipped with a current sensing function which enables the user to detect the voltage difference using the internal package inductance. Although it is challenging to apply the current sensing method using the internal inductance with high accuracy in spite of the extremely low inductance module, in this paper we propose a new current sensing algorism using the internal inductance and verified to show adequate accuracy.
THE EFFECT OF NITROGEN APPLICATION IN DIFFERENT DOSES BY FERTIGATION METHOD ON GRAIN YIELD, YIELD COMPONENTS AND QUALITY OF CORN (Zea mays L.)

This study was aimed to determine the most appropriate nitrogen amount for maize using fertigation method. Trials were conducted in 2018 and 2019 with 4 replicates according to the randomized blocks design in Sanliurfa, Turkey. Each plot area was 14 m (5 m x 2.8 m) and consisted of four rows of 5 m in length. DKC-6664 maize variety was used in the study as a crop material. Drip irrigation system was used with 5-day intervals according to daily evaporation values. Irrigation water was given using 1.25 coefficient of Class A Pan evaporation. Ten separate nitrogen doses were applied with the irrigation water at 0 kg da, 4 kg da, 8 kg da, 12 kg da, 16 kg da, 20 kg da, 24 kg da 28 kg da, 32 kg da and 36 kg da (1 da = 1000 m). According to the results of the two-year average, grain yield ranged from 434 to 1594 kg da. The leaf area per plant varied between 112 and 621 cm plant, protein content between 7.39% and 8.84%, starch content between 70.90% and 71.62%, and oil content between 4.20% and 4.66%. In general, the properties examined increased from the N0 application to the N28 application. Increasing nitrogen doses applied by fertigation method had a positive effect on the investigated properties. Based on average of years, the highest grain yield was determined in 28 kg da nitrogen application with fertigation system. However, no statistical difference was observed between N24 and N28 applications.
EFFECTS OF CADMIUM EXPOSURE ON PROXIMATE ANALYSIS AND METALLIC ELEMENT CONTENTS OF WEDGE CLAM (DONAX TRUNCULUS)

The present study was designed to investigate the proximate (moisture, dry matter, ash, and fat content) composition and metallic element contents (Ca, Zn, Fe, and Cd) in an edible Bivalve, Donax trunculus from the gulf of Annaba, and to evaluate the effect of cadmium (Cd) on these parameters. The clams were collected from the El-Battah site during the morphologically ripe and reared stages under laboratory conditions. Physicochemical parameters of seawater samples including temperature, pH, salinity, and dissolved oxygen were determined. Cadmium at two sub-lethal concentrations (LC10 and LC25-96h as determined previously) was added to the rearing water. The results revealed significant effects of Cd concentrations, exposure time, and sex on all the studied parameters. Indeed, the contents of dry matter, fat and metallic elements, excluding Cd were significantly decreased, while the moisture, ash, and Cd contents were significantly increased in both sexes at two sub-lethal concentrations. Moreover, the measurement of proximate composition and minerals contents in D. trunculus could be a very useful approach to evaluate the nutritive value changes in case of exposure to cadmium contamination, and subsequently to avoid health-associated problems.