Miracle-dz/UniFAR-FTUs huggingface dataset:
Influence of time to admission to a comprehensive stroke centre on the outcome of patients with intracerebral haemorrhage

Introduction In patients with spontaneous intracerebral haemorrhage, it is uncertain if diagnostic and therapeutic measures are time-sensitive on their impact on the outcome. We sought to determine the influence of the time to admission to a comprehensive stroke centre on the outcome of patients with acute intracerebral haemorrhage. Patients and methods We studied a prospective database of consecutive patients with intracerebral haemorrhage attended at two comprehensive stroke centres (2005–2017). We excluded patients with an unwitnessed time of onset of the intracerebral haemorrhage, or previous modified Rankin Scale >3 or in those in whom withdrawal of life-sustaining interventions were decided <24 h from admission. We recorded the time from the intracerebral haemorrhage onset to admission, demographic, clinical, radiological data, the functional outcome (favourable when modified Rankin Scale ≤3) and mortality at 90 days. We conducted a propensity score-matching analysis to evaluate functional outcome and mortality. Results We included 487 patients (mean age 72.3 ± 13.9 years), and 53.2% were men. Compared to patients with an admission >110 min, patients who were admitted ≤110 min were significantly younger, and had higher National Institutes of Health Stroke Scale scores. Moreover, patients admitted ≤110 min were more likely to have basal ganglia intracerebral haemorrhage, and to show neurological deterioration. The propensity score groups were well matched. We did not find an association between time to admission and the favourable outcome (OR: 1.42 (95% CI: 0.93–2.16)) or mortality (OR: 0.64 (0.41–0.99)) at 90 days. Conclusions Our results suggest that in patients with intracerebral haemorrhage and known symptom onset who are admitted to a comprehensive stroke centre, an early admission (≤110 min) does not influence the outcome at 90 days.
Trends and outcomes of fungal infections in hospitalized patients of inflammatory bowel disease: a nationwide analysis.

Background Immunosuppressive therapy is being increasingly used in the management of inflammatory bowel disease (IBD) which comprises of ulcerative colitis (UC) and Crohn's disease (CD). Patients on immunosuppressive therapy are at increased risk of developing opportunistic fungal infections. We conducted this analysis to describe the epidemiology of opportunistic fungal infections in this cohort. Methods We analyzed the National Inpatient Sample (NIS) database for all subjects with discharge diagnosis of IBD (UC and Crohn's disease) & Fungal infections (Histoplasmosis, Pneumocystosis, Cryptococcosis, Aspergillosis, Blastomycosis, candidiasis, Coccidioidomycosis) as primary or secondary diagnosis via ICD 9 codes during the period from 2002-2014. Results In UC, the incidence of all fungal infections was more in age above 50 (except for pneumoconiosis) male gender (except Candidiasis) and in Caucasians. In CD, the incidence was more in age above 50 (except Pneumocystosis, Blastomycosis & Coccidioidomycosis), female gender (except Histoplasmosis, Pneumocystosis & Cryptococcosis) and in Caucasians. Histoplasmosis and Blastomycosis were more prevalent in Midwest, Cryptococcosis and Candidiasis in South, Coccidioidomycosis in west in both UC and CD. Age above 50, south region, HIV, Congestive heart failure, underlying malignancies, diabetes mellitus with complications, chronic pulmonary disease, anemia, rheumatoid arthritis, collagen vascular disease, pulmonary circulation disorders, weight loss were significant predictors of fungal infections in IBD. The yearly trend showed a consistent small rise in incidence, and the mortality dropped till 2006 to peak again in 2008 with a subsequent decline. Conclusions Our study is the first one to describe the basic demographics features and characteristics of opportunistic fungal infections in hospitalized patients with IBD. The yearly incidence of fungal infections did not show a significant rise. The mortality increased between 2006-2008 and a significant difference remains between IBD patients with and without fungal infections. One explanation of rise in mortality but a consistent incidence could be due to the use of biologics that did not increase but compromised the ability of IBD patients to fight opportunistic fungal infections.
Passenger Emotional Response Type and Timing during Automated Vehicle Intersection Negotiation

Most automated vehicle studies have focused on limited automation where the role of the user is that of a driver, supervisor or fallback, but comparatively fewer have considered riders. If riders’ experiences are ignored, it could undermine the adoption of the technologies and, consequently, the realization of their anticipated benefits. A driving simulator study was conducted to evaluate the response of riders to intersection negotiation with conservative, moderate, or aggressive automated driving styles. Riders’ emotional responses—operationalized as changes in facial action units—were detected using video processing software. Results showed that changes in speed, acceleration, and jerk preceded changes in the facial action units and were associated with the magnitude of the change. The speed, acceleration, and jerk changes were represented in different automated driving styles that then affected the magnitude and timing of emotion response. Facial action units may provide a way to gauge riders’ emotional responses to vehicle control algorithms could be used to improve rider experiences.
Over 17% efficiency ternary organic solar cells enabled by two non-fullerene acceptors working in an alloy-like model

Nowadays, organic solar cells (OSCs) with Y6 and its derivatives as electron acceptors provide the highest efficiencies among the studied binary OSCs. To further improve the performances of OSCs, the fabrication of ternary OSCs (TOSCs) is a convenient strategy. Essentially, morphology control and the trade-off between voltage and photocurrent are the main critical issues in TOSCs. Herein, we address these problems by constructing TOSCs where an alloy-like composite is formed between Y6 and a newly designed derivative, BTP-M. Employing an electron-pushing methyl substituent as a replacement for the electron-withdrawing F atoms on Y6, BTP-M shows higher energy levels and lower crystallinity than Y6. As a result, the obtained Y6:BTP-M alloy can simultaneously optimize energy levels to reduce energy loss as well as the morphologies of the active layers to favor photocurrent generation, leading to an enhanced open-circuit voltage (Voc) of 0.875 V together with a larger short-circuit current density (Jsc) of 26.56 mA cm−2 for TOSCs based on the polymer donor PM6 and Y6:BTP-M acceptor alloy. Consequently, a best efficiency of 17.03% is achieved for the corresponding TOSCs, which is among the best values for single-junction OSCs. In addition, our TOSCs also exhibit good thickness tolerance, and can reach 14.23% efficiency even though the active layer is as thick as 300 nm.
Hereditary spastic paraplegias : clinical spectrum in Sudan, further deciphering of the molecular bases of autosomal recessive forms and new genes emerging

Hereditary spastic paraplegias (HSP), a heterogeneous group of spastic neurodegenerative disorders which impose diagnostic challenges. I explored the clinical varieties and genetic pathways of spastic neurodegeneration in a familial Sudanese cohort. We recruited 41 Sudanese families [337 individuals/106 HSP patients]. I have established a genomic DNA bank and when necessary, skin biopsies and fibroblasts were also obtained. A phenotype-based candidate gene approach was followed in 4 families. A targeted next generation sequencing (NGS) for 74 HSP-related genes was the main screening strategy in all-remaining 37 families. Whole exome sequencing (WES) was done in search for novel mutations in new genes in families with negative screening results. Occasionally, functional studies were conducted when feasible and relevant. I identified the genetic cause in 17/41 families. In 12 families, the mutated genes were known HSP genes. In 3 families, novel genes were identified mutated. 5 candidate genes segregated with disease in 2 other families with more experiments needed to conclude. Analysis of the NGS screening panel and of WES data imposed certain challenges as multiple genetic disorders were sometimes found running in parallel in the same/different branches of highly inbred families. We could expand the phenotypic heterogeneity of these disorders due to clinical differences observed between Sudanese patients and patients of other origins even when caused by mutations by the same gene/variant. This is the first genetic screening in a large set of HSP families in Sudan. It describes new causative genes, paving the way for further deciphering of the underlying mechanisms.
DRUG UTILIZATION PATTERN IN GERIATRIC PATIENTS ATTENDING OUT PATIENT DEPARTMENT AT RURAL TERTIARY CARE HOSPITAL IN MAHARASHTRA.

Objective: To observe a prescription pattern in elderly patients attending outpatient department (OPD) and evaluating prescriptions according to theWorld Health Organization (WHO) prescription indicators. Methods: A cross-sectional observational study was conducted from July to September 2015. Patients of either gender, age 60 years or more, attending OPD in tertiary care hospital were included in the study. Prescriptions of medical practitioners were collected and evaluated for demographic data and the WHO drug prescribing indicators. R esults: A total of 600 patients were enrolled in the study. The majority of the patients were in the age group 60-69 years (66.33%) with male preponderance (61%). The average number of drugs per prescription was 3.41. Out of 2045 drugs prescribed, 1261 drugs (61.66%) were prescribed by their generic name and 784 drugs (38.33%) were prescribed by their brand name. 1700 drugs (83.12%) prescribed were from the WHOs essential medicines list 2015. Total encounters involving injectable usage were 0.15%. Drugs acting on the cardiovascular system (21.12%) were the most frequently prescribed, followed by nonsteroidal anti-inflammatory drugs (NSAIDs) (20%). Ranitidine (16.62%) is the most frequently prescribed drug. C onclusions: In this study, drug prescription pattern was rational as per the WHO drug prescribing indicators. However, issues such as polypharmacy and inaccuracies of dose and duration were seen. Ke ywords: Drug utilization study, Geriatric, Outpatient department, Rational use of medicines.
PENGARUH CITRA MEREK DAN KUALITAS LAYANAN TERHADAP LOYALITAS PELANGGAN MASKAPAI GARUDA INDONESIA

Currently, the tourism sector in Indonesia is on the rise with the promotion of the Wonderful Indonesia campaign and making domestic and foreign tourists to travel in Indonesia. One of the most widely used transportation options is airplanes because the aircraft is the fastest and safest transportation to reach distant tourist sites. Garuda Indonesia is one of the most widely used airlines to travel because of its brand image and quality of service. The research method used is judgment sampling by collecting data through questionnaires distributed to 100 respondents who have used Garuda Indonesia airline service more than 1 times. Measuring tools in this research are validity test, reliability test, percentage, average, Likert scale, classical assumption test, and multiple linear regression test. The tool used is SPSS 20.0. Based on multiple linear regression analysis, it is found that there is significant and positive influence of brand image and service quality to customer loyalty of Garuda Indonesia Airlane. Keywords : Brand Image, Service Quality, Customer Loyalty, Garuda Indonesia
The profiles of children pushed to crime who are treated in a regional psychiatric hospital in Turkey

Objective: The study was conducted to determine the profiles of the children pushed into crime who treated in psychiatric hospital between the years of 2010-2014. Methods: The study, designed as a Retrospective cohort, was conducted by examining the file records of 144 adolescents/children pushed into crime. These outpatient or inpatient adolescents / children were treated as forensic case in a Child and Adolescent Psychiatry Inpatient Units in a regional psychiatric hospital between the years of 2010-2014. Results: 79.9% of investigated cases were men and their average age was 15.33±1.54. It was determined that 59.0% of the cases did not attend school while the treatment period because of the legal cause and 13.2% of these cases worked as a laborer before. 65.3 % them living with their family. Of 72.2% adolescents have negative relationship with their family. 11.8% of adolescents fathers’ have alcohol-substance and 4.9% of adolescent fathers’ have abuse and legal problems. 70.8% adolescents have diagnosis of chronic mental illness, 13.9% of them has more than one psychiatric diagnosis. 81.2's% adolescents have committed crimes for the first time and 18.8% of hem has repeated crime stories. It was determined that adolescents who have migration story and bad family relationships in their past involved in the crimes. Conclusion: It was determined that many of the adolescents pushed in to crime have mental disorder, their academic success and parents’ educational level are low , they have past migration story and the adolescents having a negative family relationships commit repetitive crime.
Role of virtual avatars in digitalized hotel service

This study aim to attempt to conceptualize agency in a hospitality setting and examine the psychological effects of agency-related visual cues on user perception and intention to use to understand the role of agency in the digitalization of hotel services. ,After developing demo videos of an express check-out application, two experiments were conducted to examine the effects of using an avatar and explain the psychological mechanism of how attributes of an avatar increase intention to use. ,Study 1 found that the presence of an avatar had a positive influence on intention to use. Study 2 retested the findings of Study 1 and illustrated the psychological mechanism of how two attributes of an avatar (social position and gender) influenced perceived expertise and intention to use. A significant interaction effect between social position and gender was found on perceived expertise. Perceived expertise also mediated the effect of an avatar on intention to use in the male avatar conditions. ,As the first attempt to investigate the role of avatars in human–computer interaction in a hotel setting, this study will serve as an example in testing the effects of agency-related technical features on user experience and behavioral intention, possibly broadening the current research scope of hospitality and tourism. This study also provides a useful guideline to develop and design a successful interface of digitalized hotel services.
A Framework for Learning From Null Results

A substantial number of randomized trials of educational interventions that have been conducted over the past two decades have produced null results, with either no impact or an unreliable estimate of impact on student achievement or other outcomes of interest. The investment of time and money spent implementing such trials warrants more useful information than simply “this didn’t work. ” In this article, we propose a framework for defining null results and interpreting them and then propose a method for systematically examining a set of potential reasons for a study’s findings. The article builds on prior work on the topic and synthesizes it into a common framework designed to help the field improve both the design and interpretation of randomized trials.
Geolocation Accuracy Improvement of Multiobserved GF-3 Spaceborne SAR Imagery

As the first C-band full-polarization spaceborne synthetic aperture radar (SAR) satellite in China, Gaofen-3 (GF-3) is of great significance in scientific research and economic development. Thanks to the advantage of all-weather and all-day observation, spaceborne SAR imagery is widely used in digital elevation model (DEM) generation, target tracking, and so on. And, all these applications are based on the high 3-D geolocation accuracy of SAR imagery. Therefore, a new slant range error update model and an error-source-based weight strategy which can effectively improve the 3-D geolocation accuracy of multiobserved data set from GF-3 satellite are proposed in this letter. The slant range error update model is proposed to improve the 3-D geolocation accuracy using the virtual control information in height direction. At the same time, an error-source-based weight strategy is introduced as an appendant to the multiobservation block adjustment model based on the rational function model (RFM). The experimental results demonstrate that our proposed method can achieve a much higher 3-D geolocation accuracy than the traditional methods.
Bank Performance in Europe and the US: A Divergence in Market-to-Book Ratios

Post 2008, the market-to-book ratios of European and US banks have diverged markedly. We use panel regressions to investigate the determinants of the M/B ratios of 112 European and US banks. We show that the underperformance of European banks is mainly driven by non-performing loans and by the negative impact of policy rates on bank interest margins. The higher US bank valuations are mainly driven by higher pro tability and better cost eciency. Our results for European banks stress the importance of timely NPL resolution and imply that low-for-long monetary policy may harm bank health.
Design, implementation, and evaluation of vehicle control systems using a side slip estimator

Vehicle control systems have been integral to the performance and stability of a vehicle. In this thesis, two vehicle control strategies namely, the yaw controller and the yaw–beta controller, were presented. The control algorithm was based on the model predictive control method. A simulation environment developed using a two track vehicle model coupled with a tire model based on the magic tire formula was used to test the controllers in different test scenarios. These tests were carried out to evaluate the performance of the two controllers with respect to performance and stability. The results showed small differences between the performance of the controllers, but enough to indicate the initial assumptions on the behaviour. The yaw–beta controller was more stable than the yaw controller at the expense of the vehicle performance. However, the results did not show significant enough differences to determine the magnitude of any potential gains.
Eight in one: morphological and molecular analyses reveal cryptic diversity in Amazonian alopoglossid lizards (Squamata: Gymnophthalmoidea)

1School of Zoology, Tel Aviv University, Tel Aviv, 6997801, Israel 2Programa de Pós-Graduação em Genética, Conservação e Biologia Evolutiva, Instituto Nacional de Pesquisas da Amazônia, Avenida André Araújo, 2936, Petrópolis, Manaus, 69067-375, Amazonas, Brazil 3Museo de Zoología, Escuela de Biología, Pontificia Universidad Católica del Ecuador, Avenida 12 de Octubre y Roca, Apartado 17-01-2184, Quito, Ecuador 4División de Herpetología, Centro de Ornitología y Biodiversidad (CORBIDI), Santa Rita No. 105 36 Of. 202, Urb. Huertos de San Antonio, Surco, Lima, Peru 5Coordenação de Biodiversidade, Programa de Coleções Científicas Biológicas, Instituto Nacional de Pesquisas da Amazônia (INPA), Avenida André Araújo, 2936, Petrópolis, Manaus, 69067-375, Amazonas, Brazil 6Department of Organismic and Evolutionary Biology, Museum of Comparative Biology, Harvard University, 26 Oxford Street, Cambridge, MA 02138, USA
Patients? Informed Consent in Dental Practice in Bulgaria

Introduction: Patients� informed consent is a legal regulation and a moral principle, determined by legislation in Bulgaria and the European Union. It represents patients� rights to take part in the clinical decisions concerning their treatment. The authors report research showing informed consent�s more important aspects related to daily relationships between dentists and patients. Aims: The main aims of this study were to investigate the use of patients� informed consent and the extent to which it is provided in Bulgarian dentists� practice. Methods: A questionnaire, which included questions on various aspects of the use of informed consent, was used to collect data from a convenience sample of 102 dentists working in the Medical University of Sofia, Faculty of Dental Medicine and the Military Medical Academy, Sofia, Bulgaria. Completed questionnaires were returned anonymously. Results: Eighty dentists completed the questionnaire. Seventy-eight (97.5%) replied that they thought informed consent was necessary. Seventy (87.5%) dentists reported that they took informed consent for all types of treatment. Of the remainder, 10 reported taking informed consent prior to surgical interventions, eight before orthodontic treatment and seven before prosthetic treatment. However, only 64 (80%) respondents reported that they always obtained informed consent from their patients. Thirty-seven (46.25%) dentists responded that they obtained the oral form of informed consent, 30 (37.5%) that they obtained written informed consent, and 13 (16.25%) that they obtained both forms. Surgical treatment was the most frequent case in which the written form was obtained. Almost all participants (70; 87.5%) reported that they should always take informed consent when they treated children. Forty-one (51.25%) reported that they obtained informed consent from all patients but 21 (26.25%) did not obtain it when treating colleagues, 29 (36.25%) from relatives, 15 (18.75%) from friends, and 10 (12.5%) from long-time patients. Conclusions: From the current survey, it can be concluded that the dentists as staff members of leading training and healthcare facilities may well have demonstrated greater awareness about questions concerning patients� informed consent than most other Bulgarian dentists. Informed consent plays a major role in the daily practice of the majority but many are not using written consent as a routine procedure. However, even though almost 100% of the dentists thought that it is necessary to get informed consent, only 80% of them obtained it in practice.
Edat relativa, minuts de competició i debut en futbol professional

The purpose of this study was to analyse the relative age effect (RAE) in all age categories in the development programme of a professional football club and to identify whether playing time and the chances of debut in the first team are influenced by the RAE. We examined the birthdate distributions of 334 elite football players from Real Club Deportivo de la Coruña: 195 young soccer players (DTG) divided into 11 age groups (U-9 to U-23), 110 professional players (FTG), and 29 players who debuted in competitive matches with the club’s first team from the youth development programme (EG). Playing time was calculated by adding up all the minutes played by a player in official competition during a season. The Chi-square test results show that the RAE exists in the 3 groups and in all the 11 age groups of the DTG players. The RAE was significantly lower in the FTG compared to the DTG and EG groups (Mann-Whitney U test, p < .05). There were no differences in playing minutes between players born in the first half of the year or in the second half of the year. These findings suggest that the RAE in elite clubs origi-nates fundamentally in the talent selection process in all categories, but mainly in the youngest ones, and is maintained in all the lower categories, influencing the chances of making a first-team debut.