Miracle-dz/UniFAR-FTUs huggingface dataset:
SMALL NUCLEOLAR AND SMALL CAJAL BODY-SPECIFIC RNA S EXPRESSION PROFILE OF OXIDATIVE STRESSED AND NORMAL RPE CELLS SUGGESTS UNKNOWN REGULATIVE ASPECTS OF RETINITIS PIGMENTOSA ETIOPATHOGENESIS

A BSTRACT . Recent discoveries on non coding RNAs (ncRNAs) suggest that a huge number of regulative mechanisms of transcription and translation in eukaryotes could represent the key to improve our knowledge on many diseases etiopathogenesis, like Retinitis pigmentosa (RP). Among ncRNAs, small nucleolar RNAs (snoRNAs), and their sub - group Small Cajal Body - specific RNAs (scaRNAs), represent an undiscovered world. We compared snoRNAs expression changes, coming from whole transcriptomes analyses, between two group of Retinal Pigment Epithelial (RPE) cells, treated with the oxidant agent oxidized low-density lipoprotein (oxLDL) and untreated, respectively, considering four time points (1h, 2h, 4h, 6h). We found 84 snoRNAs, clustered in five groups based on showed altered expressions in treated samples and targeting several ribosomal RNAs (rRNAs), presented their host genes involved in several biochemical pathways. One of them, involving the “silencing activity mediated by the interferon- γ -activated inhibitor of translation (GAIT) translational control system”, seems to be very interesting and only speculated to be associated to RP. SnoRNA expression analysis of oxidative stress induced RPE cells suggested that ncRNAs could play a relevant role in RP etiopathogenesis, regulating pathways directly or indirectly related to the considered disease.
COMPARATIVE STUDY BETWEEN DEXMEDETOMIDINE AND PROPOFOL FOR PAIN, AGITATION AND DELIRIUM IN INTENSIVE CARE

Background: Severity of acute medical illness, invasive diagnostic and therapeutic interventions and environmental influences makes the patient prone to pain, agitation and delirium in intensive care units. Several drugs are used for sedation, but it was not clear that whether a single drug is able to address all the three components of pain, agitation and delirium effectively. This study compares dexmedetomidine with propofol in the management of critically- ill patients observing their effect on sedation, pain and delirium scores and other cardio-respiratory parameters. Material & Methods: After clearance from institute ethical committee and written informed consent, patients were randomly divided to two groups of thirty each. Group D received dexmedetomidine intravenous infusion in initial dose of 0.5 mcg/kg/hr over 20 minutes followed by 0.1 mcg/kg/hr, while Group P received propofol (0.5 mg/kg/hr). Infusion rate was titrated to achieve target sedation level. RASS(Richmond agitation sedation scale), CAM-ICU(Confusion assessment method- ICU),and CPOT(Critical care pain observation tool) scores were observed for a duration of 24 hours at baseline, 20 minutes after starting the study drug and subsequently at every four hours duration. Results: Mean RASS in Group D was significantly lower (-0.23 ± 0.50) than group P (0.57 ± 1.17)]. Mean CPOT was also significantly lower (1.30 ± 0.60) in the group D than group P (2.90 ± 1.32). Delirium was also lower (1/30) in the group D than group P (4/30) but this difference was not statistically significant. Conclusion: Both propofol and dexmedetomidine can be used as sedative agent in ICU but dexmedetomidine provides better analgesia and lesser delirium episodes than propofol and thus can be used as sole agent to effectively acts on all the three components pain, agitation and delirium simultaneously.
Excluding Women’s from Political Institution through Educational Deprivation

:- The major objective of the present study was to examine educational impediments to women political status in District Dir (L)-Pakistan. A sample size of 186 of different political organization was randomly selected from total population 714. A conceptual frame work comprises of dependent variable women political status and independent variable’s educational deprivation. Moreover, dependent variable was indexed and cross tabulated with independent variable. Chi-square test statistics was applied to ascertain the relationship between dependent and independent variable respectively. In Bi-variate analysis, a highly significant (P=0.000) association was found between dependent variable women political status and independent variable indicators; Higher is the rate of education more would be women in politics; education proved to be true instrument in making right decision to poll; education empower women to work shoulder to shoulder with men; higher rate of democracy sustenance is embodied in education for all; and education enlightens political awareness among masses. The study concluded that, Education has been rewarded to be a male dominated and male leading institution. Dynamics of female involvement shoulder to shoulder with men are if taken in account from the developed countries, may lead to changing this scenario, which will ensure to dethrone the partisan character of male dominance.
OUTCOME OF CONSECUTIVE EMBRYOS TRANSFER IN REPEATED IMPLANTATION FAILURE CASES

Fertilization/ Intra Cytoplasmic Sperm Injections-Embryo Transfer (IVF/ICSI-ET) cycles or good-quality embryo transfers. [4] Probable underlying etiologies for RIF are aneuploidy of embryos, uterine cavity abnormalities, diminished endometrial response, and insufficiencies in transfer techniques. These factors result in decreased pregnancy rates even at successful IVF centers, and RIF remains a problem, of both economical and psychological aspects for couples. [5] ABSTRACT Introduction: The majority of intracytoplasmic sperm injection (ICSI) cycles lead to the transfer of embryos to the uterus, but most do not implant. Thus, the main cause of failure in IVF is implantation failure . Repeated failure in vitro-fertilization treatment is frustrating to patient and doctors, patient with good quality embryo pose a special therapeutic challenge (consecutive embryo transfer). Objectives: To examine whether consecutive transfer of embryos on day 3 and on day 5 improves ICSI success rates in patients with multiple consecutive implantation failures. Study design: This is a randomized controlled clinical trial include 100 patients randomly distributed into two groups: Group A (The study Group) consists of 50 patient subjected to Consecutive (double) embryo transfer at day 3 and at day 5. Group B (The control group): consists of 50 patient subjected to embryo transfer at day 5. Results: There was statistical non-significant difference of age, cause of infertility, number of previous trials, oocyte retrieved, and embryos available, multiple pregnancy. There was statistical significant difference of pregnancy rate and clinical pregnancy rate in two groups 54% to 34%. Conclusion: For patients with repeated ICSI-embryo transfer failures, sequential transfer on day 3 and day 5 may improve the clinical pregnancy rate in cases of repeated implantation failure as long as good-quality embryos are available. failure-embryos transfer-ICSI.
Ox) Filaments

Results on high current density high volume fraction Nb7.5Ta MEIT conductor incorporating a Sn + Ti source with a Jc of more than of 3000 A mm 2 at 12 T are presented and compared to a MEIT conductor incorporating Ti in the Sn. The effect of two fins on theDe and magnetization are discussed. Results on moderate volume fraction MEIT conductors with Nb1Zr filaments both with and without the addition of Oxygen are presented. The effect of oxygen on Jc, grain size and layer Jc are presented and discussed.
Model Di tillation for Deep Learning ased aze Estimation

With the recent advances in deep learning, the gaze estimation models reached new levels, in terms of predictive accuracy, that could not be achieved with older techniques. Nevertheless, deep learning consists of computationally and memory expensive algorithms that do not allow their integration for embedded systems. This work aims to tackle this problem by boosting the predictive power of small networks using a model compression method called "distillation" [49]. Under the concept of distillation, we introduce an additional term to the compressed model’s total loss which is a bounding term between the compressed model (the student) and a powerful one (the teacher). We show that the distillation method introduces to the compressed model something more than noise. That is, the teacher’s inductive bias which helps the student to reach a better optimum due to the adaptive error deduction. Furthermore, we show that the MobileNet family exhibits unstable training phases and we report that the distilled MobileNet25 slightly outperformed the MobileNet50. Moreover, we try newly proposed training schemes to increase the predictive power of small and thin networks and we infer that extremely thin architectures are hard to train. Finally, we propose a new training scheme based on the hintlearning method [96] and we show that this technique helps the thin MobileNets to gain stability and predictive power.
Superoxide release from contracting skeletal muscle in pulmonary TNF- (cid:1) overexpression mice

Superoxide release from contracting skeletal muscle in pulmonary TNF- (cid:1) overexpression mice. Am Physiol Physiol obstructive pulmonary disease (COPD) often results in increased levels of tumor necrosis factor- (cid:1) (TNF- (cid:1) ), a proinﬂammatory cytokine, which circulates in the blood. However, it is not clear whether pulmonary TNF- (cid:1) overexpression (a COPD mimic) induces excessive reactive oxygen species (ROS) formation in skeletal muscle and thereby may contribute to the muscle impairment often seen in COPD. We hypothesized that ROS generation in contracting skeletal muscle is elevated when there is TNF- (cid:1) overproduction in the lung and that this can induce muscle dysfunction. Cytochrome c (cyt c ) in the perfusate was used to assay superoxide (O 2 · (cid:2) ) release from isolated contracting soleus muscles from transgenic mice of pulmonary TNF- (cid:1) overexpression (Tg (cid:3) ) and wild-type (WT) mice. Our results showed that Tg (cid:3) muscle released signiﬁcantly higher levels of O 2 · (cid:2) than WT during a period of intense contractile activity (in nmol/mg wt; 17.5 (cid:4) 2.3 vs. 4.4 (cid:4) 1.3, respectively; n (cid:5) 5; P (cid:6) 0.05). In addition, the soleus muscle demonstrated a signiﬁcantly reduced fatigue resistance in Tg (cid:3) mice compared with WT mice. Perfusion of the contracting soleus muscle with superoxide dismutase, which speciﬁcally scavenges O 2 · (cid:2) in the perfusate, resulted in signiﬁcantly less cyt c reduction, thereby indicating that the type of ROS released from the Tg (cid:3) muscles is O 2 · (cid:2) . Our results demonstrate that pulmonary TNF- (cid:1) overexpression leads to a greater O 2 · (cid:2) release from contracting soleus muscle in Tg (cid:3) compared with WT and that the excessive formation of O 2 · (cid:2) in the contracting muscle of Tg (cid:3) mice leads to earlier fatigue.
Research Online Research Online Prevalence and risk factors of food insecurity among a cohort of older Prevalence and risk factors of food insecurity among a cohort of older Australians Australians

Abstract Objective With ongoing national concern about food security, the aim of the study was to estimate the prevalence of food insecurity and to identify associated characteristics in a cohort of older Australians. Design, participants The Blue Mountains Eye Study is a cohort study of community living participants aged 49 + years. The 12-item food security survey was completed by 3068 participants in the cross sectional study which comprised 2335 survivors from baseline and the recruitment of an additional 1174 eligible residents. determine ABSTRACT 3 Objective: With ongoing national concern about food security, the aim of the study was to estimate 4 the prevalence of food insecurity and to identify associated characteristics in a cohort of older 5 Australians. 6 7 Design, setting and participants: The Blue Mountains Eye Study is a cohort study of community 8 living participants aged 49 + years. The 12-item food security survey was completed by 3068 9 participants in the cross sectional study which comprised 2335 survivors from baseline and the 10 recruitment of an additional 1174 eligible residents. 11
Predictors of Residual Viremia in Patients on Long-term Suppressive Antiretroviral Therapy

, Abstract Background— HIV-1-infected individuals with plasma RNA <50 copies/mL on antiretroviral therapy (ART) may have residual, low-level viremia detectable by PCR assays which can detect a single copy of viral RNA (single-copy assay, SCA). The clinical predictors of residual viremia in patients on long-term suppressive ART are incompletely understood. Methods— We evaluated factors associated with residual viremia in patients on suppressive ART who underwent screening for a raltegravir intensification trial (ACTG A5244). The screened population was HIV-1-infected adults receiving ART for ≥12 months with pre-ART HIV-1 RNA >100,000 copies/mL and on-therapy RNA levels below detection limits of commercial assays for ≥6 months. Results— Of 103 patients eligible for analysis, the median age was 46 years and the median duration of viral suppression was 4.8 years. Sixty-two percent had detectable viremia (>0.2 copies/ mL) by SCA (median 0.2 copies/mL; quartile [Q] 1, Q3 [<0.2, 1.8]). Younger patients had lower HIV-1 RNA levels than older individuals (r=0.27, p=0.005). Patients with virologic suppression on ART for 2 years or less had higher residual viremia than those with suppression for more than 2 years (median 2.3 0.2 copies/mL, Conclusions— Among HIV-1-infected patients with pre-ART HIV-1 RNA >100,000 copies/ mL, residual viremia was detectable in the majority (62%) despite many years of suppressive ART. Higher level viremia was associated with older age and less than 2 years of virologic suppression on ART. These findings should help in selection of candidates for clinical trials of interventions designed to eliminate residual viremia.
Effect of spacing and nitrogen on bulb formation of Asiatic lily cv. tressor under shade net condition

A field trial was conducted to study the influence of spacing and nitrogen on bulb formation of Asiatic lily cv. Tressor. The experiment comprises of three spacing viz. 15 cm x 15 cm, 25 cm x 15 cm and 30 cm x 15 cm in combination with the three levels of nitrogen viz. 100 kg ha -1 , 150 kg ha -1 and 200 kg ha -1 were tested in Factorial Randomized Block Design. Data revealed that plant spacing of 30 cm x 15 cm and 200 kg ha -1 nitrogen level showed resulting in a significant effect on number of bulbs per plant, number of bulblets per plant, bulb diameter, bulb weight, bulb yield per plant and bulb yield per plot.
Knowledge Regarding Prevention of Novel Coronavirus (COVID-19): An Electronic Cross-Sectional Survey among Selected Rural Community

Outbreak of novel coronavirus diseases (COVID-19) is a global health emergency, it has spread over more than 150 countries. In present situation preventive measures is main key to prevent the transmissions. An electronic cross-sectional survey was conducted to assess the knowledge and create awareness among selected rural community. Structure questionnaire was created in the Google Forms, link was generated and distributed among peoples through their email and WhatsApp to participate in the survey. A total 103 subject was enrolled through convenient sampling technique. Collected data was analyzed using descriptive statistics including frequency, percentage, mean and standard deviation. Results of the study shows that majority (95.1%) of participant had adequate information regarding the prevention of COVID-19, among that 55.3% were got the information from multimedia included television, radio, newspaper and 21.4% from the internet. Most (56.3%) of the participants had adequate knowledge, 25.2% participants had moderately adequate and in 18.5% participants had inadequate knowledge regarding prevention of COVID-19. Study concluded that in most of the participants had adequate knowledge but it is not satisfactory because adequate knowledge is very essential among each and every member of the community and have to implement it into practice.
Stent Passivation with Silicon Carbide as a Possible Alternative to Drug-eluting Stents – A Comprehensive Review of Pre-clinical and Clinical Results

Metallic stenting has significantly improved short-term procedural outcomes and substantially reduced the rate of restenosis in patients undergoing percutaneous coronary interventions (PCI). Drug-eluting stents (DES) are often used in PCI procedures as they have been associated with a significant reduction in the rate of restenosis compared with PCI alone or PCI with bare-metal stents (BMS). However, there have been reports of stent thrombosis (ST) with DES, especially in patients at high risk of death, thrombosis or restenosis. Surface passivation of stents by amorphous silicon carbide (aSiC:H) coating has been shown in pre-clinical studies to reduce the thrombogenecity and possibly improve the biocompatibility of the stent surfaces. Clinical trials have generally shown low rates of ST, major adverse cardiac events (MACE) and target lesion revascularisation (TLR) in patients with stenotic lesions, with these rates also being low in high-risk patients. Based on indirect comparisons of aSiC:H-coated stents with DES, the former may be alternatives to DES, especially in high-risk patients. formation, thrombosis and restenosis. 28,29 Surface passivation aims to improve the biocompatibility of the material, thereby reducing these interactions and, in turn, reducing thrombogenecity. Passivation is also intended to decrease the rate of restenosis and prevent the delay in endothelialisation. 25,30–32 Surface passivation aims to achieve reduction in the interaction of blood constituents with the stent surface by using semi-conducting materials to inhibit electron transfer between the blood constituents and metallic surfaces. 33–35 This inhibition can prevent the unwanted effects of protein/cell–stent interaction, as electron transfer from the protein solution to the metallic surface induces neointima formation and activation of the clotting cascade. This article will review the results of pre-clinical and clinical studies to evaluate the potential of aSiC:H-coated metallic stents as alternatives to DES.
Role of Amino- and Carboxyl-Terminal Regions of G (cid:97) z in the Recognition of G i -Coupled Receptors

Many G i -coupled receptors are known to interact with the pertussis toxin (PTX)-insensitive G z protein. Given that the (cid:97) subunits of G i and G z share only 60% identity in their amino acid sequences, their receptor-interacting domains must be highly similar. By swapping the carboxyl termini of (cid:97) i2 and (cid:97) z with each other or with those of (cid:97) t, (cid:97) 12, and (cid:97) 13, we examined the relative contributions of the carboxyl-end 36 amino acids of the (cid:97) chains toward receptor recognition. Chimeric (cid:97) chains lacking the site for PTX-catalyzed ADP-ribosylation were coex- pressed with the type II adenylyl cyclase (AC II) and one of several G i -coupled receptors (formyl peptide, dopamine D 2 , and (cid:100) -opioid receptors) in human embryonic kidney 293 cells. The (cid:97) i2/ (cid:97) z chimera was able to interact with both aminergic and peptidergic receptors, resulting in (cid:98)(cid:103) -mediated stimulation of AC II in the presence of agonists and PTX. Functional and mutational analyses of (cid:97) i2/ (cid:97) z revealed that this chimera can inhibit the endogenous ACs of 293 cells. Similarly, the (cid:97) z/ (cid:97) i2 chimera seemed of t1 a chimera, t1/ z, did not couple to any of the G i -coupled an (cid:97) 13/ (cid:97) z chimera (with only the last five amino acids switched) displayed differential abilities to interact with receptors. Signals from aminergic, but not peptidergic, receptors were transduced by (cid:97) 13/ (cid:97) z. A similar construct, (cid:97) 12/ (cid:97) z, behaved just like (cid:97) 13/ (cid:97) z. These results indicated that “ (cid:97) i-like” or “ (cid:97) z-like” sequences at the carboxyl termini of (cid:97) subunits are not always necessary or sufficient for specifying interaction with G i -coupled receptors.
Title: Frontal Lobe Volume, Function, and A (cid:1) Pathology in a Canine Model of Aging Abbreviated Title: Frontal Lobe Volume and Aging in the Beagle

Application of MRI techniques reveals that human brain aging varies across cortical regions. One area particularly sensitive to normal aging is the frontal lobes. In vitro neuropathological studies and behavioral measures in a canine model of aging previously suggested that the frontal lobes of the dog might be sensitive to aging. In the present study, MRI scans were acquired to compare age-related changes in frontal lobe volume with changes in executive function and (cid:1) -amyloid pathology in the frontal cortex of beagle dogs aged 3 months to 15 years. Decreases in total brain volume appeared only in senior dogs (age 12 and older) while frontal lobe atrophy developed earlier, appearing in the old dogs (aged 8-11 years). Hippocampal volume also declined with age but not occipital lobe volume past maturity. Reduced frontal lobe volume correlated with impaired performance on measures of executive function including inhibitory control and complex working memory, and with increased (cid:1) -amyloid accumulation in the frontal cortex. Age-related hippocampal atrophy also correlated with complex working memory but not inhibitory control, whereas occipital lobe volume did not correlate with any cognitive measure. These findings are consistent with the frontal lobe theory of aging in humans, which suggests that the frontal lobes and functions subserved by this region are compromised early in aging.
Comparative Study of Post-Marriage Nationality Of Women in Legal Systems of Different Countries

This study is conducted in order to evaluate the effectiveness of the resiliency training on the perceived stress of the mothers of the children with autism. This study is quasi-experimental with the pretest-posttest design and the control group. The population of this study is consisted of all of the mothers of the autistic children who are aged between 3 to 10 years old and received services at the Tehran Autism Center in 2018. The study sample is consisted of 30 mothers who were selected by the convenient sampling method, and were randomly assigned into the experimental (15 people) and control (15 people) groups. The Perceived Stress Scale of Cohen et al. (1983) was used in order to collect the data. The Resiliency training was given to the study group in nine sessions, and each session lasted for one hour. The SPSS-22 statistical software was used for the data analysis. The results of this study showed that the intervention (the resiliency training) reduced the perceived stress (P=0.000, F=26.862) in experimental group (P <0.05). However, there was no significant difference between the pre-test and post-test in the control group. Totally, it can be concluded that the resiliency training plays an effective role in the management of the stress in the mothers of the autistic children.