Miracle-dz/UniFAR-FTUs huggingface dataset:
Piezoelectric energy harvester under parametric excitation: A theoretical and experimental investigation

In the present work, both theoretical and experimental investigation of a vertical cantilever beam–based piezoelectric energy harvester are carried out under principal parametric resonance condition. A piezoelectric patch is attached near the fixed end of the cantilever beam along with an attached mass positioned at an arbitrary location. The extended Hamilton’s principle is used to derive the spatio-temporal equation of motion, and generalized Galerkin’s approximation is used to obtain the temporal nonlinear electromechanical governing equation of motion. The method of multiple scales is used to find the reduced modulation equations. Due to large transverse deflection and effect of rotary inertia of the attached mass, the system exhibits cubic and inertial nonlinearities. An experimental setup with slider crank mechanism–based shaker and a harvester consisting of a cantilever beam with piezoelectric patch and attached mass is designed and developed. The challenges posed by parametric resonance in crack development in the PZT and in the beam are reported. The theoretical and experimental output voltage and the power obtained are found to be in good agreement. Furthermore, a qualitative and quantitative comparative study of 17 energy harvesters has been carried out, and the normalized power densities have been compared.
Evaluation of the Efficacy and Safety of Switching to Pasireotide in Patients With Acromegaly Inadequately Controlled With First-Generation Somatostatin Analogs

Introduction: Acromegaly is a rare, serious endocrine disorder characterized by excess growth hormone (GH) secretion by a pituitary adenoma and overproduction of insulin-like growth factor I (IGF-I). Transsphenoidal surgery is the treatment of choice, although many patients require additional interventions. First-generation somatostatin analogs (SSAs) are the current standard of medical therapy; however, not all patients achieve control of GH and IGF-I. Outcomes from a Phase IIIb open-label study of patients with uncontrolled acromegaly on first-generation SSAs switching to pasireotide are reported. Methods: Adults with uncontrolled acromegaly (mean GH [mGH] ≥1 μg/L from a five-point profile over 2 h, and IGF-I >1.3× upper limit of normal [ULN]) despite ≥3 months' treatment with maximal approved doses of long-acting octreotide/lanreotide received open-label long-acting pasireotide 40 mg/28 days. Pasireotide dose could be increased (maximum: 60 mg/28 days) after week 12 if biochemical control was not achieved, or decreased (minimum: 10 mg/28 days) for tolerability. Patients who completed 36 weeks' treatment could continue receiving pasireotide during an extension (weeks 36–72) when concomitant medication for acromegaly was permitted. Primary endpoint was proportion of patients with mGH <1 μg/L and IGF-I <ULN at week 36. Biochemical control was also assessed during the extension. Safety was assessed throughout. Results: One hundred and twenty-three patients were enrolled and received pasireotide; 88 patients continued into the extension. Overall, 18 [14.6% (95% CI: 8.9–22.1)] patients achieved mGH <1 μg/L and IGF-I <ULN at week 36; biochemical control was achieved in 42.9% with screening mGH 1.0–2.5 μg/L and 6.4% with screening mGH >2.5 μg/L. For patients who entered the extension, 14.8% (95% CI: 8.1–23.9), 12.5% (95% CI: 6.4–21.3), 14.8% (95% CI: 8.1–23.9) and 11.4% (95% CI: 5.6–19.9) had mGH <1 μg/L and IGF-I <ULN at weeks 36, 48, 60, and 72, respectively. During the overall study period, most frequent investigator-reported drug-related adverse events were hyperglycemia (41.5%), diabetes mellitus (23.6%), and diarrhea (11.4%). Conclusions: Switching to long-acting pasireotide provided biochemical control in some patients, which was sustained with continued treatment. Long-term safety and tolerability of long-acting pasireotide was consistent with the known safety profile. These data support long-acting pasireotide for some patients with acromegaly who are uncontrolled on first generation SSAs. Clinical Trial Registration: clinicaltrials.gov, identifier: NCT02354508.
The Neural Mechanisms of Associative Memory Revisited: fMRI Evidence from Implicit Contingency Learning

The literature describes a basic neurofunctional antagonism between episodic memory encoding and retrieval with opposed patterns of neural activation and deactivation, particularly in posterior midline regions. This has been coined the encoding/retrieval (E/R) flip. The present fMRI study uses an innovative task paradigm to further elucidate neurofunctional relations of encoding and retrieval in associative memory. Thereby, memory encoding is implemented as implicit (non-deliberate) cognitive process, whereas the prior literature focused mainly on explicit encoding. Moreover, instead of defining brain activations related to successful (vs. unsuccessful) memory performance, the task paradigm provides proper no-memory baseline conditions. More specifically, the encoding task includes trials with non-contingent (not learnable) stimulus combinations, while the retrieval task uses trials with a simple matching exercise with no mnemonic requirements. The analyses revealed circumscribed activation in the posterior middle cingulate cortex (pMCC) together with prominent deactivation in the anterior insula cortex (aIC) as core neural substrate of implicit memory encoding. Thereby, the pMCC exhibited positive functional connectivity to the hippocampus. Memory retrieval was related to an activation pattern exactly opposed to memory encoding with deactivation in the pMCC and activation in the aIC, while the aIC additionally exhibited a negative (i.e., arguably inhibitive) functional connectivity to the pMCC. Important to note, the observed pattern of activations/de-activations in the pMCC appears to conflict with prevalent E/R flip findings. The outlined results and their (alleged) discrepancies with prior study reports are discussed primarily in the context of the default mode network’s functioning and its context-sensitive regulation. Finally, we point out the relevance of the present work for the understanding and further investigation of the neurofunctional aberrations occurring during normal and pathological aging.
Effect of Manual Upper Eyelid Elevation on Intraocular Pressure Measurement by Four Different Tonometers.

SIGNIFICANCE This study is the first to show that the manual upper eyelid elevation (manual UEE) that is commonly used to prevent disruption of the IOP measurement due to blinking or upper eyelid contact with the tip of the tonometer does not affect the IOP values. PURPOSE We investigated whether manual UEE affects the IOP readings using three rebound tonometers (Icare TA01i, Icare PRO, and Icare ic100) and Goldmann applanation tonometry (GAT). METHODS One eye was measured for 101 patients (56 eyes of primary open-angle glaucoma patients and 45 healthy subjects). The IOPs were measured without and with manual UEE. Each IOP was measured twice; the measurement order using the tonometers was randomly selected. In addition, palpebral fissure height (distance between the upper and lower eyelids) was measured. RESULTS The IOPs without manual UEE were 12.1 ± 2.9, 13.3 ± 2.7, 11.7 ± 2.9, and 16.0 ± 3.2 mmHg (Icare TA01i, Icare PRO, Icare ic100, and GAT), and those with manual UEE were 12.3 ± 3.0, 13.3 ± 2.8, 11.7 ± 2.9, and 16.0 ± 3.3, respectively. No significant difference was found between the IOP without and with manual UEE (IOP difference; all, P > .50; paired t test). Multiple linear regression analyses revealed that palpebral fissure height did not affect IOP difference for any of the tonometers. CONCLUSIONS Simple manual UEE when measuring the IOP has little effect on the IOP obtained using all current rebound tonometers and GAT.
Subfoveal Choroidal Thickness in Pre-eclampsia.

SIGNIFICANCE To our knowledge, this is the first time a study looking at the association between subfoveal choroidal thickness (SFCT) and the parameters affecting the severity of pre-eclampsia has been reported. We provide evidence that SFCT is thicker in pre-eclamptic (PE) patients and speculate on the possible causes. PURPOSE The purposes of this study were to compare SFCT in PE, normal pregnant, and nonpregnant women using spectral domain optical coherence tomography and to correlate SFCT with severity of pre-eclampsia. METHODS A cross-sectional, observational study was performed. A total of 150 participants were divided into three groups: group 1 (50 PE women), group 2 (50 normal pregnant women), and group 3 (50 nonpregnant healthy women). Subfoveal choroidal thickness was measured using spectral domain optical coherence tomography. Other parameters including mean arterial blood pressure (MABP), central corneal thickness, macular thickness, IOP, ocular perfusion pressure (OPP), and urine protein-to-creatinine ratio were also measured. ANOVA and Pearson correlation analysis were used to look at differences between the groups. P < . 05 was considered as statistically significant. RESULTS The MABP was higher in group 1 than in groups 2 and 3 (103.0 ± 12.9 vs. 83.2 ± 9.8 vs. 89.5 ± 7.2 mmHg, respectively; all P < .001). The SFCT of the PE group was higher than in groups 2 and 3 (370.7 ± 23.8 vs. 344.5 ± 30.8 vs. 315.8 ± 49.9 μm, respectively; all P < .001). There were no statistically significant differences in central corneal thickness, macular thickness, or IOP between the PE and healthy pregnant groups (all P > .05). The OPP was greater in PE patients (52.8 ± 8.5 vs. 41.9 ± 6.9 vs. 43.4 ± 5.2 mmHg, respectively; both P < .001). The SFCT was positively correlated with MABP (r = 0.464, P < .001), OPP (r = 0.495, P < .001), and urine protein-to-creatinine ratio (r = 0.635, P < .001) in the PE group. CONCLUSIONS Subfoveal choroidal thickness is higher in pre-eclampsia and is proportional to established markers of severity of the condition. This parameter might serve as a novel predictive marker for the severity of pre-eclampsia.
Assessing Corneal Speckle in Optical Coherence Tomography: A New Look at Glaucomatous Eyes.

SIGNIFICANCE Optical coherence tomography speckle is used here in an unconventional way as the indirect source of information on tissue microstructure. The study reveals that the corneal speckle of glaucoma suspects has a similar relationship between the parameters of scattering exhibited in glaucoma patients. PURPOSE The purpose of this study was to evaluate the potential of optical coherence tomography imaging of the cornea in early diagnosis of glaucoma. METHODS Corneas of 64 subjects of three groups, including 18 primary open-angle glaucoma patients, 24 glaucoma suspects with normal levels of IOP and uncompromised visual field, and 22 age-matched controls, were imaged with spectral optical coherence tomography. A central region of interest in each optical coherence tomography image visualizing the stroma was automatically extracted, and the intensity data within that region were fit with the generalized gamma distribution. Its parameters describe the scatterer cross section and scatterer density and indirectly assess corneal microstructure. In addition, subjects underwent measurements of IOP, visual field, Heidelberg Retinal Tomography, retinal nerve fiber layer thickness, and biometry. Group means of all parameters were tested for equality. Within each group of subjects, correlation was evaluated between the statistical parameters of the corneal speckle. RESULTS Glaucoma suspects had statistically significantly different IOP, visual field parameters, mean retinal fiber layer thickness, and central corneal thickness from those of glaucoma patients but not from those of the control group. The parameters of the corneal speckle were not significantly different between the groups, but they showed a markedly higher and statistically significant coefficient of determination for glaucoma patients and suspects than that for the control group (0.927 and 0.707 vs. 0.336). CONCLUSIONS The results indicate that glaucoma suspects have similar relationship between the corneal scatterer cross section and scatterer density to that exhibited in the glaucoma patients but markedly different from that of healthy controls.
Determining Significant Elevation of Intraocular Pressure Using Self-tonometry.

SIGNIFICANCE Icare HOME rebound tonometry is increasingly adopted into clinical practice for IOP phasing of glaucoma patients and suspects. Because of measurement differences with applanation tonometry and diurnal fluctuations, interpretation of the IOP measured with Icare HOME phasing can be challenging. PURPOSE The purpose of this study was to use a large patient cohort to develop a practical, analytical tool for interpreting Icare HOME measurements with respect to applanation pressure. METHODS IOP measurements using the Icare HOME and an applanation tonometer were taken prospectively in 498 consecutive patients. Bland-Altman, frequency distribution, and linear regression analysis were applied to determine measurement differences. A novel criterion, Threshold Icare HOME IOP, was developed to assist identification of elevation above target applanation pressure, considering the expected diurnal variation and measurement variability. RESULTS Icare HOME tended to underestimate applanation tonometry (mean bias, -1.7 mmHg; 95% limits of agreement, -7.0 to +3.6). Overall, differences were within ±3 mmHg in 71.5% and ±5 mmHg in 92% of patients. Based on the novel criterion developed, Icare HOME measurements that exceed target applanation pressure by 6 mmHg or greater are generally outside the 95% limit of expected observations. CONCLUSIONS The Threshold Icare HOME IOP is a novel and practical criterion that can assist clinicians in their interpretation of Icare HOME phasing measurements with respect to target applanation pressures. Elevation above the expected thresholds may prompt closer monitoring or even modifications to glaucoma management.
Prognostic factors at birth for stunting at 24 months of age in rural Indonesia

Background The problems of stunting are its high prevalence as well as the complexity of its risk factors. Identifying the modifiable prognostic factors at birth may reduce the shortterm as well as longterm effects of stunting in later life. Objective To estimate the influence of prognostic factors detected at birth for stunting at 24 months of age and the occurence of reversal of stunting at 24 months of age among children in a rural area of Indonesia. Methods Subjects (n=343) were born to mothers participating in a randomized controlled, double-blind, community-based study of vitamin A and/or zinc supplementation during pregnancy and followed from June 1998 to October 2000. The children were followed prospectively from birth until 2 years of age with monthly measurements of length from birth to 12 months, and again at 18 and 24 months. Data on potential prognostic factors detected at birth, i.e., maternal, child, and household facilities, were collected by trained field workers at home visits. The incidence and risk ratio were calculated to assess the influence of the possible prognostic factors detected at birth on stunting at 24 months of age among these children. Results Boys who were born prematurely had significantly higher risk of stunting at 24 months of age compared to girls born maturely. The incidences of stunting at 24 months of age according to gender, and gestational age were 33.9% boys vs. 22.5% girls (RR 1.80; 95%CI 1.06 to 3.09), and 33.3% premature vs. 27.6% mature (RR 7.11; 95%CI 2.07 to 24.48), respectively. Conclusion Boys who were born prematurely have significantly higher risk to become stunted at 24 months of age. The occurrence of reversal of stunting at 24 months of age is low.
Optimizing Heart Rate and Controlling Symptoms in Atrial Fibrillation

Atrial fibrillation (AF) is the most common pathologic clinical arrhythmia lasting more than 30 seconds, and its incidence and prevalence continue to increase. It has been estimated that 5.9 % of patients aged >65 years suffer from AF. In the Rotterdam study, 17.8 % of patients over 85 had AF. The lifetime risk for developing AF in both men and women above age 40 is one in four. This arrhythmia, with its attendant comorbidities, poses a substantial physical, psychologic, and financial burden on the populace and is a significant public health concern. Evaluating and managing AF appropriately at the primary care level (by minimizing risk factors) and recognizing and treating the arrhythmia immediately will play important roles in containing this epidemic. This review article addresses the recognition of AF and the importance of distinguishing it from other arrhythmias with an irregular pulse. It discusses the available options for stroke reduction and examines the correlation between symptoms and rhythms. It then reviews existing and potentially novel approaches to rate and rhythm control and their role in controlling symptoms in patients with AF.
Tree Species Traits Determine the Success of LiDAR-Based Crown Mapping in a Mixed Temperate Forest

The ability to automatically delineate individual tree crowns using remote sensing data opens the possibility to collect detailed tree information over large geographic regions. While individual tree crown delineation (ITCD) methods have proven successful in conifer-dominated forests using Light Detection and Ranging (LiDAR) data, it remains unclear how well these methods can be applied in deciduous broadleaf-dominated forests. We applied five automated LiDAR-based ITCD methods across fifteen plots ranging from conifer- to broadleaf-dominated forest stands at Harvard Forest in Petersham, MA, USA, and assessed accuracy against manual delineation of crowns from unmanned aerial vehicle (UAV) imagery. We then identified tree- and plot-level factors influencing the success of automated delineation techniques. There was relatively little difference in accuracy between automated crown delineation methods (51–59% aggregated plot accuracy) and, despite parameter tuning, none of the methods produced high accuracy across all plots (27—90% range in plot-level accuracy). The accuracy of all methods was significantly higher with increased plot conifer fraction, and individual conifer trees were identified with higher accuracy (mean 64%) than broadleaf trees (42%) across methods. Further, while tree-level factors (e.g., diameter at breast height, height and crown area) strongly influenced the success of crown delineations, the influence of plot-level factors varied. The most important plot-level factor was species evenness, a metric of relative species abundance that is related to both conifer fraction and the degree to which trees can fill canopy space. As species evenness decreased (e.g., high conifer fraction and less efficient filling of canopy space), the probability of successful delineation increased. Overall, our work suggests that the tested LiDAR-based ITCD methods perform equally well in a mixed temperate forest, but that delineation success is driven by forest characteristics like functional group, tree size, diversity, and crown architecture. While LiDAR-based ITCD methods are well suited for stands with distinct canopy structure, we suggest that future work explore the integration of phenology and spectral characteristics with existing LiDAR as an approach to improve crown delineation in broadleaf-dominated stands.
Development of Water Level Prediction Models Using Machine Learning in Wetlands: A Case Study of Upo Wetland in South Korea

Wetlands play a vital role in hydrologic and ecologic communities. Since there are few studies conducted for wetland water level prediction due to the unavailability of data, this study developed a water level prediction model using various machine learning models such as artificial neural network (ANN), decision tree (DT), random forest (RF), and support vector machine (SVM). The Upo wetland, which is the largest inland wetland in South Korea, was selected as the study area. The daily water level gauge data from 2009 to 2015 were used as dependent variables, while the meteorological data and upstream water level gauge data were used as independent variables. Predictive performance evaluation using RF as the final model revealed 0.96 value for correlation coefficient (CC), 0.92 for Nash–Sutcliffe efficiency (NSE), 0.09 for root mean square error (RMSE), and 0.19 for persistence index (PI). The results indicate that the water level of the Upo wetland was well predicted, showing superior results compared to that of the ANN, which was used in a previous study. The results intend to provide basic data for development of a wetland management method, using water levels of previously ungauged areas.
Reappraisal Value of a Modified Rotational Atherectomy Technique in Contemporary Coronary Angioplasty Era

Objectives To introduce a modified rotational atherectomy (RA) procedure and investigate the early and midterm outcomes of the RA-facilitating diversified percutaneous coronary intervention (PCI) in a large group of aged patients with higher cardiovascular risk. Background Previous studies about the outcomes of RA were limited with small sample size and low-risk population. Methods Between January 2013 and November 2015, 1169 consecutive patients treated with modified RA-facilitated PCI were retrospectively enrolled, including de novo calcified lesions and in-stent restenosis. Patients were regularly followed up for at least 1 year. Major adverse cardiac events (MACE) were analyzed for all participants by different strategies. Cox regression analysis was performed to identify risk factors for the events. Results The median age of patients was 75 years, with 11.7% of patients on maintenance hemodialysis. Most lesions (99.9%) were complex (American Heart Association type B2/C), and 68.3% were treated with RA + drug-eluting-stent (DES). Successful angiography was achieved in 97.8% cases, with 1.7% (20/1169) experiencing coronary perforation (including guidewire perforation). The incidence of MACE was 20.5% and 26.8% at 1-year and 2-year follow-up and were mainly driven by target lesion revascularization (TLR) (10.3% and 12.5%, respectively). The strategy of RA + DES had the lowest 2-year MACE, compared with the RA + drug-coated balloon and RA + plain old balloon angioplasty (14.5%, 30.5%, and 26.0%, respectively). Conclusions The modified RA technique is a safe and effective tool in the contemporary PCI era, even in high-risk patients. The TLR rate was relatively high but acceptable in such complex lesions.
Readiness of the Swaziland sugar industry towards the use of information and communication technology: perceptions of smallholder sugarcane farmers and extension officers

The study investigated smallholder sugarcane farmers and extension officers’ perceptions of readiness towards the use of Information and Communication Technology (ICT), especially cell phones, as a source of technology for accessing information within the Swaziland sugar industry. The study was a census involving all active smallholder sugarcane farmers in Swaziland (N=172) and their extension officers (N=17). Quantitative data were collected through face-to-face interviews using a valid and reliable structured questionnaire. Descriptive statistics and one way analysis of variance (ANOVA) were applied to analyse the data. The results revealed that sugarcane farmers and extension officers perceive the Swaziland sugar industry to be ready for the introduction and subsequent use of ICTs to access sugarcane production information. The sugar industry infrastructure and other facilities that are necessary for the use of cell phones were perceived to be ready. All respondents possessed cell phones which they personally owned. The entire sugar industry had access to cellular network and electricity. It was also shown that some demographic variables of respondents did have an influence on their perceptions regarding the industry’s readiness towards the use of cell phones to access information. The results of this study can provide guidance to the government and the sugar industry of Swaziland when considering implementing improved information dissemination based programmes.