Miracle-dz/UniFAR-FTUs huggingface dataset:
[18F]FDG PET-MR in the Evaluation and Follow-Up of Incidental Bone Ischemic Lesions in a Mono-Center Cohort of Pediatric Patients Affected by Hodgkin’s Lymphoma

Hodgkin’s lymphoma (HL) is one of the neoplasms with the best prognosis in children, adolescents and young adults, but sufferers are burdened by the possibility of developing adverse effects such as Bone Ischemic Lesions (BILs) which are lesions of the bone caused by the loss of/reduction in blood flow. The main goal of this retrospective study was to evaluate the role of [18F]FDG-PET-MR in the early detection of BILs in a single-center cohort of uniformly treated pediatric HL patients. BILs were assessed through PET-MR images as the appearance of medullary lesion surrounded by a serpiginous, tortuous border. From 2017 to 2022, 10/53 (18.9%) HL patients developed BILs which were mostly (8/10 patients) multifocal. Overall, 30 lesions were identified in the 10 asymptomatic patients, all with the above-mentioned features at MR and with very low [18F]FDG uptake. BILs were incidentally detected during HL therapy (n = 6) and follow-up (n = 4), especially in the long bones (66.7%). No factors correlated with the occurrence of BIL were identified. No patients developed complications. PET-MR is a sensitive combined-imaging technique for detecting BILs that are asymptomatic and self-limiting micro-ischemic lesions. BILs can be monitored by clinical follow-up alone both during and after therapy.
Job satisfaction and professional development among teachers working under two parallel top-down reforms

ABSTRACT Following the increasing demand to improve educational systems, ‘top-down’ reforms were developed targeting teachers’ work conditions alongside new professional development policy. The current study aimed to examine the perceptions of teachers who are employed under two reforms in parallel, regarding their job satisfaction and professional development. Semi-structured interviews were conducted with 20 teachers who work simultaneously under the two reforms. Based on analysis technique that focuses on content, four themes related to teachers’ job satisfaction were identified: workload and multiple tasks; inherent satisfaction; the struggle between personal and professional identities; and ‘broken’ routine. In addition, three themes regarding professional development were found: forced and limited; unnatural and disconnected to the field; and workload as ruling out a profound process. Taking all the themes into consideration, three portraits of teachers were found: the praising, the flowing, and the embittered. Implications and meaning of the findings will be further discussed.
PDAE models of integrated circuits and index analysis

A coupled system modelling an electric circuit containing semiconductors is presented. The modified nodal analysis leads to a differential algebraic equation (DAE) describing the electric network. The nonlinear behaviour of the semiconductors is modelled by the drift diffusion equations. Coupling relations are defined and a generalization of the tractability index to systems of infinite dimensions is presented and applied to the resulting partial differential algebraic equation (PDAE). The PDAE turns out to have the same index as the electrical network equations.
Information Reconstruction-Based Polarimetric Covariance Matrix for PolSAR Ship Detection

In the last decades, how to detect ships with polarimetric synthetic aperture radar (PolSAR) has become one hot topic. Unfortunately, most of the existing ship detection methods cannot well detect small ships with weak backscattering. To deal with this issue, a ship detection matrix named complete polarimetric covariance matrix [CP] was recently proposed from the perspective of spatial information utilization. Although it is able to improve small ships’ target-to-clutter ratio (TCR) values, its calculation strategy still needs to be rethought due to the possible information loss of some ships. Besides, its mathematical characteristic (i.e., not positive semidefinite) also limits the successful applications of some existing polarimetric theories to it. To overcome these two drawbacks, we here develop an information reconstruction-based polarimetric covariance matrix [IC]. In brief, one new difference calculation strategy is first performed on the Sinclair matrix [<inline-formula> <tex-math notation="LaTeX">$S$ </tex-math></inline-formula>], so as to reconstruct its information, by which a feature vector <inline-formula> <tex-math notation="LaTeX">$v$ </tex-math></inline-formula> is subsequently extracted with the Lexicographic matrix basis. Then, via further performing an outer product operation on <inline-formula> <tex-math notation="LaTeX">$v$ </tex-math></inline-formula>, the matrix [IC] is proposed. Meanwhile, to demonstrate the effectiveness of [IC] in ship detection, two different [IC]-based intensity detectors, respectively, named SPANIC and PEDIC, are designed as well. Experiments carried out on three GF-3 PolSAR datasets show that: 1) the proposed matrix [IC] has a better performance than [CP] and the original polarimetric covariance matrix [<inline-formula> <tex-math notation="LaTeX">$C$ </tex-math></inline-formula>] in ship detection and 2) compared to the total power detector SPAN and geometrical perturbation-polarimetric notch filter (GP-PNF), both SPANIC and PEDIC can better detect ships, especially the small ships.
How Do Health, Biological, Behavioral, and Cognitive Variables Interact over Time in Children of Both Sexes? A Complex Systems Approach

The present study examined gender differences in health, physical activity, physical fitness, real and perceived motor competence, and executive function indicators in three time points, and analyzed the dynamic and non-linear association between health, biological, behavioral, and cognitive variables in children followed over time. A total of 67 children (aged between six and 10 years) were followed during two years and split into two cohorts (six to eight years old: C1; eight to 10 years old: C2). Data regarding health, physical activity, real and perceived motor competence, physical fitness, and executive function indicators were obtained according to their respective protocols. Comparison tests and network analysis were estimated. Significant gender differences were found in both cohorts. The emerged networks indicated different topologies in both cohorts. No clusters were observed between the variables in C1, and there was a greater number of interactions at eight years of age. Sparse networks were observed in children aged eight and 10 years in C2, and greater connectivity was observed at nine years of age between health, physical fitness, motor competence, and physical activity indicators. This study showed that there are non-linear dynamic relationships between health, biological, behavioral, and cognitive variables over time during child development.
The Contribution of Kawada to the Analytical Solution for the Velocity Induced by a Helical Vortex Filament

The basic solution for the velocity induced by helical vortex filament is well known as Hardin's solution, published in 1982. A study of early publications on helical vortices now shows that the Japanese scientist Kawada from Tokyo Imperial University also produced many of these results in 1936, which predates Hardin by 46 years. Consequently, in order to honor both, we have studied their derivations to establish the originality of both solutions.
Time-Domain Finite Element Simulation of Conductive Regions

Transient magnetic fields are analyzed in the time domain by using the finite-element method (FEM) in space and the finite-difference method in time. Conductive regions are eliminated from the domain under examination by imposing impedance boundary conditions on the surfaces separating conductive and nonconductive regions. In the time domain, the impedance boundary conditions are represented by a convolution integral in which the transient surface admittance appears whose expression can be obtained analytically by the inverse Laplace transform. A 2-D numerical procedure is presented for the solution of the integral equation deriving from the application of surface impedance boundary conditions. >
Financial Performance as Intervening Variable Affect of Intellectual Capital and Capital Structure on Firm Value in the Banking Sector

Study purpose decide the affect intellectual capital and capital structur on value company, mediated by financial performance. This studies was conduct at banking firm on the Indonesia Stock Exchange in 2018-2021, where there were 46 company populations. Sampels taken use non-probability method sampling with purposive sampling tecnic, with criterias: 1) Banking firms publish consecutive financial reports, 2) Banking firms do not experience losses or negative profit during a certain period. There were 26 sample companies with 106 total observation companies. The technique analysis data use in this studies the path analysis method. Result of this study indicate intellectual capital, capital structure significant and positive impact on value firm, intellectual capital and capital structure has a positive and significant impact on financial performance, financial has significant and positive impact on value company, financial performance is could to mediate intellectual capital on value company, financial performance is could to mediate capital structure on banking company value on the Indonesia Stock Exchange in 2018-2021
Pre-service mathematics teachers’ concept images of radian

This study investigates pre-service mathematics teachers’ concept images of radian and possible sources of such images. A multiple-case study was conducted for this study. Forty-two pre-service mathematics teachers completed a questionnaire, which aims to assess their understanding of radian. Six of them were selected for individual interviews on the basis of theoretical sampling. The data indicated that participants’ concept images of radian were dominated by their concept images of degree. As the data in this study suggested, pre-service mathematics teachers were reluctant to accept trigonometric functions with the inputs of real numbers but rather they use value in degrees. More interestingly, they have two distinct images of π : π as an angle in radian and π as an irrational number.
Surface ground vibration due to a moving train in a tunnel : Two-dimensional model

Abstract Vibration of a surface of a two-dimensional (2D) elastic layer generated by a point load moving uniformly along a beam, which is located inside the layer is investigated theoretically. It is supposed that the layer possesses a small viscosity, is fixed along the bottom, and has a traction-free surface. The beam is described by the Euler–Bernoulli model and located parallel both to the surface and the bottom of the layer. The surface vibration is analysed under three types of the load, namely constant, harmonically varying and a stationary random load. For the deterministic loads, the vector displacement of an observation point on the layer surface is analyzed along with the amplitude spectrum of vibration in this point. For the random load main attention is paid to the variance of vibration at the observation point. Qualitative features of obtained results are discussed via kinematic analyses of the wave propagation in the structure.
Targeting Human Endothelial Cells with Glutathione and Alanine Increases the Crossing of a Polypeptide Nanocarrier through a Blood–Brain Barrier Model and Entry to Human Brain Organoids

Nanoparticles (NPs) are the focus of research efforts that aim to develop successful drug delivery systems for the brain. Polypeptide nanocarriers are versatile platforms and combine high functionality with good biocompatibility and biodegradability. The key to the efficient brain delivery of NPs is the specific targeting of cerebral endothelial cells that form the blood–brain barrier (BBB). We have previously discovered that the combination of two different ligands of BBB nutrient transporters, alanine and glutathione, increases the permeability of vesicular NPs across the BBB. Our aim here was to investigate whether the combination of these molecules can also promote the efficient transfer of 3-armed poly(l-glutamic acid) NPs across a human endothelial cell and brain pericyte BBB co-culture model. Alanine and glutathione dual-targeted polypeptide NPs showed good cytocompatibility and elevated cellular uptake in a time-dependent and active manner. Targeted NPs had a higher permeability across the BBB model and could subsequently enter midbrain-like organoids derived from healthy and Parkinson’s disease patient-specific stem cells. These results indicate that poly(l-glutamic acid) NPs can be used as nanocarriers for nervous system application and that the right combination of molecules that target cerebral endothelial cells, in this case alanine and glutathione, can facilitate drug delivery to the brain.
Montmorillonite–Rifampicin Nanohybrid for pH-Responsive Release of the Tuberculostatic

The present work describes the development of a hybrid and pH-responsive system for rifampicin using the clay mineral ‘montmorillonite’ as a nanocarrier. The influence of operational variables on the drug incorporation process was evaluated using 24 factorial designs. Under optimized conditions, the experiment allowed an incorporated drug dose equivalent to 98.60 ± 1.21 mg/g. Hybrid systems were characterized by different characterization techniques (FTIR, XRD, TGA, DSC, and SEM) to elucidate the mechanism of interaction between the compounds used. Through in vitro release studies, it was possible to verify the efficacy of the pH-dependent system obtained, with approximately 70% of the drug released after sixteen hours in simulated intestinal fluid. The adjustment of the experimental release data to the theoretical model of Higuchi and Korsmeyer–Peppas indicated that the release of rifampicin occurs in a prolonged form from montmorillonite. Elucidation of the interactions between the drug and this raw clay reinforces its viability as a novel carrier to develop an anti-TB/clay hybrid system with good physical and chemical stability.
Pathological images for personal medicine in Hepatocellular carcinoma: Cross-talk of gene sequencing and pathological images

Background Considering the great heterogeneity of Hepatocellular carcinoma (HCC), more accurate prognostic models are urgently needed. This paper combined the advantages of genomics and pathomics to construct a prognostic model. Methods First, we collected data from hepatocellular carcinoma patients with complete mRNA expression profiles and clinical annotations from the TCGA database. Then, based on immune-related genes, we used random forest plots to screen prognosis-related genes and build prognostic models. Bioinformatics was used to identify biological pathways, evaluate the tumor microenvironment, and perform drug susceptibility testing. Finally, we divided the patients into different subgroups according to the gene model algorithm. Pathological models were constructed by obtaining HE-stained sections from TCGA in corresponding subgroups of patients. Results In this study, we constructed a stable prognostic model that could predict overall survival in HCC patients. The signature consisted of six immune-related genes (BX537318.1, TMEM147, CSPG4P12, AC015908.3, CEBPZOS, and SRD5A3). We found increased levels of infiltration of immune cells in the tumor microenvironment in patients with low risk scores, indicating significant antitumor immunity and corresponding to better clinical outcomes. We then screened nine drugs that were more sensitive in the low-risk group than in the high-risk group. Finally, we addressed the complex cellular changes and phenotypic heterogeneity in the HCC microenvironment by combining genomics and pathomics analysis methods. Conclusion Our study showed that the prognostic evaluation model of HCC based on the immune signaling pathway is feasible and provided a reference value for potential immunotherapy for HCC.
A Method for the Determination of 3-D Velocity Fields of Disappearing Solar Filaments

The 3-D velocity fields of disappearing filaments (Disparition Brusques: DBs) on the solar disk were extensively studied in order to determine their 3-D velocity fields. Applying Beckers’ cloud model to 5 DB events observed in the Hα line center and Hα ±0.8 u A with the Flare Monitoring Telescope (FMT) at Hida Observatory, we developed a method to derive the complete 3-D velocity field of DBs. The line-of-sight velocity is obtained (i) by calculating the Hα line profile of the filament, and (ii) by measuring the Doppler shift which best fits to the observed temporal variations of contrasts of the filament. The tangential velocity is obtained by tracing the motions of the internal structures on the successive images. In this method, corrections for the effective filter bandwidths of the instrument, stray lights, and Doppler brightening effect are performed. We also discuss the velocity errors which arise from the intrinsic variations of the filament plasma during its activation, the fluctuations in intensities of the background chromosphere, and the choice of different forms of the spread function for estimating the stray light. It is emphasized that the calculation of three-dimensional vector trajectories of a disappearing filament with our method can enhance the quality of a space weather forecast with better certainty.
The Paradox of the Preface

In a number of recent papers I have been developing the theory of "nomic probability," which is supposed to be the kind of probability involved in statistical laws of nature. One of the main principles of this theory is an acceptance rule explicitly designed to handle the lottery paradox. This paper shows that the rule can also handle the paradox of the preface. The solution proceeds in part by pointing out a surprising connection between the paradox of the preface and the gambler's fallacy.
Basic Need Satisfaction through Social Media Engagement: A Developmental Framework for Understanding Adolescent Social Media Use

This article provides a theoretical review of how within notions of self-determination theory adolescents’ use of social media can contribute to both the satisfaction and/or frustration of their basic psychological needs and thus contribute to (or impede) their attainment of key developmental goals in adolescence, such as identity formation and peer affiliation, and how these may impact their overall well-being. In this way, this work provides important insights into the motivational (i.e., basic psychological need satisfaction) and developmental (i.e., identity formation and peer affiliation) processes underlying youths’ social media engagement and has important implications for future research, as well as the development of intervention and prevention efforts targeting youth experiencing negative outcomes related to their social media engagement.
Metabolomics Reveal the Regulatory Effect of Polysaccharides from Fermented Barley Bran Extract on Lipid Accumulation in HepG2 Cells

Barley bran has potential bioactivities due to its high content of polyphenols and dietary fiber, etc. Fermentation has been considered as an effective way to promote the functional activity of food raw materials. In this study, polysaccharides from barley bran extract fermented by Lactiplantibacillus plantarum dy-1 (FBBE-PS) were analyzed, and its effects on lipid accumulation and oxidative stress in high-fat HepG2 cells induced by sodium oleate were evaluated. The results showed that the molecular weight decreased and monosaccharide composition of polysaccharides changed significantly after fermentation. In addition, 50 μg/mL FBBE-PS could reduce the triglyceride (TG) content and reaction oxygen species (ROS) level in high-fat HepG2 cells by 21.62% and 30.01%, respectively, while increasing the activities of superoxide dismutase (SOD) and catalase (CAT) represented by 64.87% and 22.93%, respectively. RT-qPCR analysis revealed that FBBE-PS could up-regulate the lipid metabolism-related genes such as ppar-α, acox-1 and cpt-1α, and oxidation-related genes such as nrf2, ho-1, nqo-1, sod1, cat, etc. The metabolomics analysis indicated that FBBE-PS could alleviate lipid deposition by inhibiting the biosynthesis of unsaturated fatty acids, which is consistent with the downregulation of scd-1 expression. It is demonstrated that fermentation can alter the properties and physiological activities of polysaccharides in barley bran, and FBBE-PS exhibited an alleviating effect on lipid deposition and oxidative stress in high-fat cells.
Tiling and somatotopic alignment of mammalian low-threshold mechanoreceptors

Significance The sense of touch is essential for perceiving the physical world, sensory-motor control, and social exchange. The first step of touch perception is activation of low-threshold mechanoreceptor (LTMR) neurons that innervate the skin. LTMRs extend one axonal branch to the skin and another to the spinal cord dorsal horn. There exist at least five LTMR subtypes that innervate mouse hairy skin, each with distinct morphologies, response properties, and presumably functions. We used genetic labeling and whole-mount visualization strategies to reveal spatial relationships between axons of individual LTMRs across 2D areas of skin and the extent to which these relationships are topographically arranged within the 3D space of the spinal cord, uncovering organizational principles of the mammalian tactile sensory system. Innocuous mechanical stimuli acting on the skin are detected by sensory neurons, known as low-threshold mechanoreceptors (LTMRs). LTMRs are classified based on their response properties, action potential conduction velocity, rate of adaptation to static indentation of the skin, and terminal anatomy. Here, we report organizational properties of the cutaneous and central axonal projections of the five principal hairy skin LTMR subtypes. We find that axons of neurons within a particular LTMR class are largely nonoverlapping with respect to their cutaneous end organs (e.g., hair follicles), with Aβ rapidly adapting-LTMRs being the sole exception. Individual neurons of each LTMR class are mostly nonoverlapping with respect to their associated hair follicles, with the notable exception of C-LTMRs, which exhibit multiple branches that redundantly innervate individual hair follicles. In the spinal cord, LTMR central projections exhibit rostrocaudal elongation and mediolateral compression, compared with their cutaneous innervation patterns, and these central projections also exhibit a fine degree of homotypic topographic adjacency. These findings thus reveal homotypic tiling of LTMR subtype axonal projections in hairy skin and a remarkable degree of spatial precision of spinal cord axonal termination patterns, suggesting a somatotopically precise tactile encoding capability of the mechanosensory dorsal horn.
The convergence analysis of fully discretized particle methods for solving Vlasov-Poisson systems

Error estimates for fully discretized particle or simulation methods for multidimensional Vlasov–Poisson systems are provided. The treatment requires stability results which generalize, to the Vlasov–Poisson context, those of J. T. Beale and A. Majda [Math. Comp., 39 (1982), pp. 29–52] and those of C. Anderson and C. Greengard [SIAM J. Numer. Anal. , 22 (1985), pp. 413–440] for studying the convergence of vortex methods. With these stability results, the total error at each timestep can be studied. This approach produces estimates better than those which would be obtained by considering the errors in the semidiscrete approximation [SIAM J. Numer. Anal. , 26 (1989), pp. 249–288] separate from the errors incurred in the time discretization of the (mollified) Hamiltonian trajectory equations.