Miracle-dz/UniFAR-FTUs huggingface dataset:
Atmospheric ventilation corridors and coefficients for pollution plume released from an Industrial Facility in Ile-Ife Suburb, Nigeria

This study presents a comparative investigation of atmospheric ventilation corridors and coefficients for gaseous pollution plume released from an isolated industrial facility into the ambient air of the host community in Ile-Ife suburb, southwest Nigeria. For the months of September to December in the year 2012 and 2013, measurement of surface layer atmospheric parameters made from an instrumented mast located near the industrial facility were used to parameterize for mixing layer height (MLH). Estimates of ventilation coefficients were obtained as well as in-depth analysis of the ventilation corridors performed. With an estimated carbon monoxide (CO) emission rate of 3.37 gs -1 from the industrial facility, AERMOD regulatory dispersion model was executed within a domain covering 8 km × 6 km around the host community. Effect of monthly changes in local ventilation corridors on pollutants dispersal at the study location was analyzed. Observed speed wind at the study location was weak (monthly mean value is ~ 1.5 m-s -1 ). The wind direction was predominantly southwesterly, indicating ventilation corridors were towards the north-east of the region. Characteristic values of the atmospheric ventilation coefficients varied from month to month and from daytime (08:00 to 19:00, GMT+1) to nighttime (20:00 to 07:00, GMT+1) with daily maximum values occurring in the late afternoon between (13:00 to 17: 00, GMT+1). The maximum values obtained were 1216 m 2 s -1 and 1156 m 2 s -1 , 1760 m 2 s -1 and 1038 m 2 s -1 , 1225 m 2 s -1 and 691m 2 s -1 , and 1334 and 436 m 2 s -1 for September to December, 2012 and 2013 respectively. Nighttime values were generally low, mostly less than 200 m 2 s -1 . The study reveals that locations SE and NE of the scrap-iron recycling factory are prevalently exposed to high concentration of gaseous pollutants and the populace in those corridors is potentially susceptible to long-term adverse effects. Key words : Air pollution, ventilation coefficient, ventilation corridors, dispersion, AERMOD.
THE EFFECT OF CAR, NIM, BOPO, AND LDR ON ROA IN BUMN BANKS IN THE PERIOD 2013-2022

This study aims to see the effect of CAR (Capital Adequacy Ratio), NIM (Net Interest Margin), BOPO (Operating et al.), and LDR (Loan to Deposit Ratio) on ROA (Return on Assets) in BUMN Banks in the period 2013 - 2022. The data source for this research is secondary through the websites of each company listed on the Indonesia Stock Exchange. The population used in this study The population in this study are state-owned banks listed on the Bursa Efek Indonesia (BEI). The sample in this study is the financial statements of state-owned banks, namely Reports on Calculation of CAR, NIM, BOPO, LDR, and ROA financial ratios for 2013-2022, a total of 40 samples. The analysis technique used is R Square analysis and Path Analysis. The results of the study show that NIM and LDR have a positive effect on ROA. CAR and BOPO hurt ROA, while CAR, NIM, BOPO, and LDR affect ROA in R Square.
Influence of Wind Turbines on Seismic Records of the Gräfenberg Array

Continuous seismic signals of wind turbines (WTs) have been analyzed at 13 sites of the Grafenberg (GRF) array in Germany. The stations of the GRF array have operated continuously for 40 years and comprise the longest available digital broadband array data set. By comparing time spans before and after installation of WTs in the vicinity of the stations, their influence on background noise can be quantified. Here, a strong dependence is shown between local wind speed and the observed effects on noise spectra. Station sites with WTs within distances up to 5 km are exposed to significant disturbance in the background noise; even at distances of 15 km such signals are still visible. The geological setting at GRF with sedimentary layer below all stations seems to favor propagation of these signals. Moreover, we observe different decay patterns for signals below and above 2 Hz, which could be related to the geometry of this layer. Overall, our observations clearly document deteriorating effects of WTs to highly sensitive seismological stations.
Relationships among teachers

U novije se vrijeme u skolama posvecuje velika pozornost suradnickim oblicima nastave, razvoju odnosa među ucenicima, potice se suradnja s roditeljima, pa iznenađuje da su prilicno zanemareni odnosi među samim nastavnicima iako oni definiraju sve druge odnose unutar skoli. Stoga je cilj ovog rada na temelju literature analizirati odnose među nastavnicima s fokusom na suradnicke i kolegijalne odnose, njihova obilježja, oblike i važnosti. Tradicionalno nastavnici rade svoj posao individualno, odvojeni od svojih kolega s kojima povrsno i povremeno izmjenjuju informacije, ali slabo surađuju, pa ovaj najucestaliji oblik odnosa u skoli asocira na paralelno igranje. Procjenjuje se kao neucinkovit model, suprotan suvremenim tendencijama povezivanja i umrežavanja na svim razinama. Potom se analiziraju mogucnosti i prednosti stvaranja bliskih odnosa ili radnih prijateljstva, koja nerijetko zbog kolizije interesi prerastaju u sukobe i neprijateljstva. Nastavnici se rjeđe sukobljavaju oko zadataka i oko procesa, a cesce oko odnosa. Objasnjava se i specifican oblik neprijateljstva među nastavnicima – horizontalni mobbing, odnosno ucestalo zlonamjerno, neprofesionalno ponasanje pojedinca ili grupe zaposlenika prema pojedinim kolegama s ciljem da ih uvrijede, ponize, ugroze, nanesu stetu njihovom zdravlju, ugledu, dostojanstvu i profesionalnom statusu. Umjesto odnosa zasnovanih na moci, sugerira se poticanje i gradnja odnosa zasnovanih na suradnji, a sto je pretpostavka za ostvarivanje kolegijalnosti koja obuhvaca profesionalne, socijalne i emocionalne interakcije na radnom mjestu. A kljucni cimbenici za uspostavu kolegijalnih odnosa su: međusobna potpora i povjerenje ; međusobno opažanje nastave i zajednicko izvođenje ; zajednicko planiranje i procjena ; razmjena ideja i znanja ; ucenje od drugih ; zajednicki razvoj kurikuluma i dijeljenje resursa. Kolegijalni odnosi se povezuju s osobnom dobrobit i profesionalnim razvojem nastavnika, ali i dobrobiti ucenika te skole u cjelini.
The Effect of Upper Eyelid Blepharoplasty on Corneal Tomography and Epithelial Profile

Introduction Upper tarsal mechanical forces influence corneal epithelial thickness profile, which could modulate corneal astigmatism. Upper eyelid blepharoplasty reduces upper tarsal strength and may have an impact on ocular surface. The aim of this study is to evaluate the effect of upper eyelid blepharoplasty on corneal epithelial thickness profile, astigmatism and aberrations. Methods Patients with dermatochalasis underwent bilateral upper eyelid blepharoplasty. Anterior segment optical coherence tomography (AS-OCT) (Zeiss Cirrus 5000 HD-OCT) and Pentacam (Oculus, Wetzlar Germany) were performed before surgery and in the 8th postoperative week. Corneal epithelial thickness, keratometry, aberrations and asphericity were considered for statistical purposes. Only right eyes were considered. A p-value lower than 0.05 was considered significant. Results Thirty eyes of 30 patients were included. The degree of astigmatism did not change after surgery (0.95D vs 0.83D, p=0.23). The difference between preoperative and postoperative steepest axis was 3.1° (p=0.04) with a tendency to change toward the vertical meridian. Mean epithelial thickness was higher in the inferior region both pre- and postoperatively and did not change. ET in the superior octant was lower (42 µm vs 45 µm, p<0.01) and the difference between inferior and superior octants (I-S) was higher (7 µm vs 3 µm, p<0.001) before surgery. There were no statistically significant changes in corneal aberrations (p=0.52) and asphericity (p=0.41) after surgery. Conclusion Our results support that upper tarsus pressure influences epithelial thickness profile and, consequently, the corneal steepest keratometry. These results lead us to postulate that upper eyelid blepharoplasty may influence biometric and keratometric measurements.
Epithelial-to-mesenchymal transition, inflammation, subsequent collagen production, and reduced proteinase expression cooperatively contribute to cyclosporin-A-induced gingival overgrowth development

Drug-induced gingival overgrowth (DIGO), induced by certain immunosuppressive drugs, antihypertensive agents, and antiepileptic drugs, may contribute to the formation of deeper periodontal pockets and intractableness in periodontitis. To date, multiple factors such as enhanced matrix production, inflammation, and reduced matrix degradation might be involved in the pathogenesis of DIGO. We have previously reported that SPOCK-1, a heparan sulfate proteoglycan, could affect gingival thickening by promoting epithelial-to-mesenchymal transition (EMT) in gingival keratinocytes. However, few studies have investigated whether a combination of these factors enhances the DIGO phenotype in animal models. Therefore, we investigated whether SPOCK-1, periodontal inflammation, and cyclosporin-A (CsA) could cooperatively promote gingival overgrowth. We first confirmed that Spock-1 overexpressing (Spock1-Tg) mice showed significantly thicker gingiva and greater alveolar bone loss than WT mice in response to ligature-induced experimental periodontitis. DIGO was induced by the combination of CsA administration and experimental periodontitis was significantly enhanced in Spock1-Tg mice compared to that in WT mice. Ligature-induced alveolar bone loss in CsA-treated Spock1-Tg mice was also significantly greater than that in CsA-treated WT mice, while being accompanied by an increase in Rankl and Col1a1 levels and a reduction in matrix metalloprotease expression. Lastly, SPOCK-1 promoted RANKL-induced osteoclast differentiation in both human peripheral blood mononuclear cells and murine macrophages, while peritoneal macrophages from Spock1-Tg mice showed less TNFα and IL-1β secretion than WT mice in response to Escherichia coli lipopolysaccharide. These results suggest that EMT, periodontal inflammation, and subsequent enhanced collagen production and reduced proteinase production contribute to CsA-induced DIGO pathogenesis.
A Peripheral Blood Signature of Increased Th1 and Myeloid Cells Combined with Serum Inflammatory Mediators Is Associated with Response to Abatacept in Rheumatoid Arthritis Patients

Abatacept (CTLA4-Ig)—a monoclonal antibody which restricts T cell activation—is an effective treatment for rheumatoid arthritis (RA). Nevertheless, only 50% of RA patients attain clinical responses, while predictors of response are rather limited. Herein, we aimed to investigate for early biomarkers of response to abatacept, based on a detailed immunological profiling of peripheral blood (PB) cells and serum proteins. We applied flow cytometry and proteomics analysis on PB immune cells and serum respectively, of RA patients starting abatacept as the first biologic agent. After 6 months of treatment, 34.5% of patients attained response. At baseline, Th1 and FoxP3+ T cell populations were positively correlated with tender joint counts (p-value = 0.047 and p-value = 0.022, respectively). Upon treatment, CTLA4-Ig effectively reduced the percentages of Th1 and Th17 only in responders (p-value = 0.0277 and p-value = 0.0042, respectively). Notably, baseline levels of Th1 and myeloid cell populations were significantly increased in PB of responders compared to non-responders (p-value = 0.009 and p-value = 0.03, respectively). Proteomics analysis revealed that several inflammatory mediators were present in serum of responders before therapy initiation and strikingly 10 amongst 303 serum proteins were associated with clinical responses. Finally, a composite index based on selected baseline cellular and proteomics’ analysis could predict response to abatacept with a high sensitivity (90%) and specificity (88.24%).
Marine productivity and terrigenous matter supply : the variability of the Subtropical Convergence around Tasmania during the last 500 ka

This study focussed on temporal and spatial changes in export productivity and terrigenous flux, in response to the varying oceanographical frontal system, in the Tasmanian Seaway since 500 ka. Four sites, drilled during ODP-Leg 189, were studied: Site 1168 (western Tasmanian margin), Sites 1170 and 1171 (Tasman Rise), and Site 1172 (East Tasman Plateau). Downcore variations in geochemical proxy data allowed to reconstruct the position of the oceanographical frontal system in the Southern Ocean since 500 ka. The paleoproductivity was assessed from the accumulation rates of carbonate, organic carbon, excess barium, and chlorins. For the first time chlorin was used in the Southern Ocean to reconstruct paleoproductivity. Siliciclastic material, by means of the aluminium, iron and titanium concentrations, was used as proxy for the supply of terrigenous matter. Their ratios provided evidence for the origin of the terrigenous material as being wind-blown dust. In general, the interglacial periods were characterised by less productivity and a lower terrigenous supply. The Subtropical Convergence was located south of 49°S during the interglacial isotopic stages 1 - 7. During marine isotopic stages 9 - 13, increased export productivity suggests a increased influence of Subantarctic Surface Water at the southern Site 1171. This indicates a position of the Subtropical Convergence and the zone of the westerlies more to the north. During the glacials, the frontal system was shifted to the north. The Subtropical Convergence reached as far north as between 42°S and 39°S east of Tasmania and between 44°S and 40°30’S west of Tasmania during the glacials. Reduced productivity during marine isotopic stages 8, 10 and 12 at the southern Site 1171 suggests that the Subantarctic Front was located to the north of Site 1171. The high glacial productivity in the nutrient-rich Subantarctic Surface Water was mainly caused by an increased supply of iron, delivered by strengthened westerly winds. These results indicate that the “Iron Hypothesis” is applicable for the studied area. It can be concluded that strong glacial/interglacial changes have determined the variations in the oceanographic frontal system in the Tasmanian Seaway. In general, the frontal system in the study area shifted to the south since 500 ka.
Anaerobic digestion of animal manure - implications for crop yields and soil biota in organic farming.

Anaerobic digestion of farmyard manures may help farmers to produce bioenergy instead of using fossil fuels, support cycling of nutrients and reduce greenhouse gas emission. However, compared to pristine slurry, digested slurry has a reduced content of organic carbon which may impact the soil biota negatively due to substrate shortage. Our knowledge on these processes and their influence on soil quality is scarce. Hence, a field experiment with two organic cropping systems (grass-clover ley and arable system; at two slurry-application levels) was established in 2011, to study how application of digestates affects crop yields, soil characteristics and soil biota (earthworms, springtails, microbiota). The grass-clover system showed comparable yield levels over 3 years when digested slurry was compared to untreated slurry. Digested slurries had no influence on soil nutrient concentrations or on soil organic matter levels over the first 2 years. Application of high levels of manure increased the mortality of both surface-dwelling and soil-living earthworms just after application, but the long-term effect of manure application seemed more positive, especially at low application levels. Springtails and microorganisms seemed only little affected by application of digested slurry.
ADVERSE AGRICULTURAL CONSEQUENCES OF WEATHER MODIFICATION

For at least fifteen years, with ever increasing frequency and extent, weather modification and/or climate alteration investigations have been conducted without public disclosure to perfect a covert methodology for inhibiting rainfall to deliberately damage a sovereign nation’s agri-cultural economy. This research discloses methodology for inhibiting rainfall, the evidence of coal combustion fly ash utilization, the adverse consequences on agriculture, and the adverse health implications on biota, including humans. The harm to agriculture comes primarily from aluminum addition to soil, changing soil pH and changing historic weather patterns. Aluminum in a chemically mobile form, not only harms plants, but is toxic to most biota, including humans. The micron and submicron particulates are used for weather modification contain heavy metals and radioactive elements which pose potentially grave human health threats including, but not limited to, cardiovascular disease, diabetes, respiratory diseases and reduced male fertility. Understanding that methodology and its adverse consequences by the agricultural community is crucial to identify and stop covert operations aimed at damaging the agricultural economy of a sovereign nation.
The 5-/12-lipoxygenase-BLT2 cascade induces elevated expression of c-Myc, thus mediating the proliferation and migration of KRAS mutant colorectal cancer cells

ABSTRACT Colorectal cancer (CRC) is the most common malignant tumor and one of the leading causes of cancer-related death worldwide. Oncogene KRAS is a commonly mutated in CRC and plays crucial roles in the colorectal tumorigenesis. Emerging evidence suggests that increased expression levels of c-Myc are critical for KRAS-mediated CRC progression. However, it is unclear exactly how c-Myc expression is regulated in CRC. In the present study, we found that blockade of 5/12-lipoxygenase (5/12-LO) or leukotriene B4 receptor (BLT2) markedly reduced c-Myc expression in KRAS-mutant LOVO cells, while the control COLO 320DM cells were not affected. When the 5/12-LO products LTB4 and 12(S)-HETE, ligands of BLT2, were added to LOVO cells, c-Myc expression levels were restored, together suggesting that ‘5/12-LO-BLT2 cascade’ regulates c-Myc expression in KRAS-mutant CRC cells. We also observed that ‘5/12-LO-BLT2’-mediated c-Myc upregulation contributes to cell proliferation by regulating the expression of cyclin D1 in LOVO cells. Moreover, ‘5/12-LO-BLT2-cMyc’ cascade regulates the expression of EMT-related proteins in KRAS-mutant CRC cells, and depletion of both c-Myc and BLT2 using siRNA significantly enhanced the level of E-cadherin and reduced the level of Vimentin in LOVO cells. Taken together, our findings suggest that the BLT2-linked cascade promotes KRAS-mutant CRC cell proliferation and migration through the elevated expression of c-Myc. Thus, our results suggest that BLT2 appears to be an effective therapeutic target for KRAS-mutant CRCs.
The impact of learners’ disruptive behaviour on teachers’ well-being: a qualitative approach

The study was carried out to investigate the impact of learners’ disruptive behaviour on teacher well-being. To achieve this aim, a phenomenological research design was used. The convenience sampling technique was adopted, as participants who were the most accessible to the researcher were contacted. The participants in this study were teachers from four different secondary schools in Bloemfontein. A total of ten teachers were selected to take part in this study. The data collection instrument for this study was a semi-structured interview schedule. The thematic analysis method was used, as this method makes it easier for the researchers to read and organise the data, as well as to make sense of the data by coding and grouping the themes. The findings from the study show that learners’ disruptive behaviours have a negative impact on teachers’ well-being. It is therefore concluded that learners’ disruptive behaviours have a severe negative impact on teachers’ overall well-being.
Magnetocardiography at rest predicts cardiac death in patients with acute chest pain

Introduction Sudden cardiac arrest is a major cause of morbidity and mortality worldwide and remains a major public health problem for which better non-invasive prediction tools are needed. Primary preventive therapies, such as implantable cardioverter defibrillators, are not personalized and not predictive. Most of these devices do not deliver life-saving therapy during their lifetime. The individual relationship between fatal arrhythmias and cardiac function abnormalities in predicting cardiac death risk has rarely been explored. Methods We retrospectively analyzed the measurements at rest for 191 patients with acute chest pain (ACP) magnetocardiographically. Our recently introduced analyses are able to detect inhomogeneities of the depolarization and repolarization. Moreover, electrically silent phenomena—intracellular ionic currents as well as vortex currents—can be measured and quantified. All included ACP patients were recruited in 2009 at Yonsei University Hospital and were followed up until 2022. Results During half of the follow-up period (6.5 years), 11 patients died. Out of all the included nine clinical, eight magnetocardiographical, and nine newly introduced magnetoionographical parameters we tested in this study, three parameters revealed themselves to be outstanding at predicting death: heart rate-corrected QT (QTc) prolongation, depression of repolarization current IKr + IKs, and serum creatinine (all significant in Cox regression, p < 0.05). They clearly predicted cardiac death over the 6.5 years duration (sensitivity 90.9%, specificity 85.6%, negative predictive accuracy 99.4%). Cardiac death risk was more than ninefold higher in patients with low repolarization reserve and QTc prolongation in comparison with the remaining patients with ACP (p < 0.001). The non-parametric Kaplan–Meier statistics estimated significantly lower survival functions from their lifetime data (p < 0.001). Discussion To the best of our knowledge, these are the first data linking magnetocardiographical and magnetoionographical parameters and subsequent significant fatal events in people, suggesting structural and functional components to clinical life-threatening ventricular arrhythmogenesis. The findings support investigation of new prevention strategies and herald those new non-invasive techniques as complementary risk stratification tools.