Miracle-dz/UniFAR-FTUs huggingface dataset:
Society of Cardiovascular Anesthesiologists Clinical Practice Update for Management of Acute Kidney Injury Associated With Cardiac Surgery

Cardiac surgery-associated acute kidney injury (CS-AKI) is common and is associated with increased risk for postoperative morbidity and mortality. Our recent survey of the Society of Cardiovascular Anesthesiologists (SCA) membership showed 6 potentially renoprotective strategies for which clinicians would most value an evidence-based review (ie, intraoperative target blood pressure, choice of specific vasopressor agent, erythrocyte transfusion threshold, use of alpha-2 agonists, goal-directed oxygen delivery on cardiopulmonary bypass [CPB], and the “Kidney Disease Improving Global Outcomes [KDIGO] bundle of care”). Thus, the SCA’s Continuing Practice Improvement Acute Kidney Injury Working Group aimed to provide a practice update for each of these strategies in cardiac surgical patients based on the evidence from randomized controlled trials (RCTs). PubMed, EMBASE, and Cochrane library databases were comprehensively searched for eligible studies from inception through February 2021, with search results updated in August 2021. A total of 15 RCTs investigating the effects of the above-mentioned strategies on CS-AKI were included for meta-analysis. For each strategy, the level of evidence was assessed using the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) methodology. Across the 6 potentially renoprotective strategies evaluated, current evidence for their use was rated as “moderate,” “low,” or “very low. ” Based on eligible RCTs, our analysis suggested using goal-directed oxygen delivery on CPB and the “KDIGO bundle of care” in high-risk patients to prevent CS-AKI (moderate level of GRADE evidence). Our results suggested considering the use of vasopressin in vasoplegic shock patients to reduce CS-AKI (low level of GRADE evidence). The decision to use a restrictive versus liberal strategy for perioperative red cell transfusion should not be based on concerns for renal protection (a moderate level of GRADE evidence). In addition, targeting a higher mean arterial pressure during CPB, perioperative use of dopamine, and use of dexmedetomidine did not reduce CS-AKI (a low or very low level of GRADE evidence). This review will help clinicians provide evidence-based care, targeting improved renal outcomes in adult patients undergoing cardiac surgery.
Novel ensemble approach for landslide susceptibility index assessment in a mountainous environment of India

Abstract Landslide is one of the important geophysical hazards that can cause a severe damage in the society and economy. Anthropogenic activities, on the other hand, are accelerating the probability and extent of the landslide. As a result, a proper estimation of the landslide probability is an essential step in contemporary research. The novel ensemble approach of ‘Weight of Evidence (WOE)’, ‘Logistic Regression (LR)’, ‘WOE-Classification and Regression Tree (CART)’, ‘WOE-Multilayer perceptron (MLP)’ and ‘WOE-Extreme Gradient Boosting (XGBoost)’ has been considered for estimating the landslide susceptibility of Kalimpong district in India. In validation datasets, the AUC values of ensembles ‘MLP-WOE, CART-WOE, LR-WOE and XGBoost-WOE’ are 0.924, 0.953, 0.940 and 0.944, respectively. According to its predictive abilities, the ensemble of ‘LR-WOE’ is the most optimum model, followed by ‘XGBoost-WOE, CART-WOE and MLP-WOE’. Aside from that, the ‘WOE’ model was used to assess the importance of sub-parameters individually.
Drivers and barriers to fashion rental for everyday garments: an empirical analysis of a former fashion-rental company

Abstract We analyze the business models of online business-to-consumer (B2C) fashion rental and share challenges and lessons learned from an in-depth case study of a former German fashion-rental company. The firm focused on renting everyday, rather than special occasion, clothing, thus increasing the potential sustainability impact of its offer significantly. We also examine drivers and barriers of both an everyday children’s wear and a women’s wear rental model by incorporating both retailer and consumer perspectives through business data, manager interviews, and consumer surveys with customer and target groups. All data were merged into a single, in-depth analysis of the business models. By combining the complementary viewpoints of retailer and consumers, we were able to more precisely pinpoint the locations of the difficulties in the business models. The main barriers to success were the worsening quality of the company’s inventory and its difficulty acquiring and retaining customers, due both to a lack of familiarity with the concept of fashion rental and the poorly perceived price-performance ratio of fashion rental. These issues suggest that online-fashion rental should begin by focusing on special occasion rentals with more high-end fashion options and should plan a sizeable budget for marketing to raise consumer awareness of alternatives to traditional retail models and alleviate customer concerns. If such a rental model is successful and establishes a stable customer base, everyday fashion-rental options could be explored as a supplement. The article demonstrates the importance of integrating different data sources to obtain a comprehensive understanding of why online-rental models fail or succeed.
Short-Chain Fatty Acids in Chronic Kidney Disease: Focus on Inflammation and Oxidative Stress Regulation

Chronic Kidney Disease (CKD) is a debilitating disease associated with several secondary complications that increase comorbidity and mortality. In patients with CKD, there is a significant qualitative and quantitative alteration in the gut microbiota, which, consequently, also leads to reduced production of beneficial bacterial metabolites, such as short-chain fatty acids. Evidence supports the beneficial effects of short-chain fatty acids in modulating inflammation and oxidative stress, which are implicated in CKD pathogenesis and progression. Therefore, this review will provide an overview of the current knowledge, based on pre-clinical and clinical evidence, on the effect of SCFAs on CKD-associated inflammation and oxidative stress.
Delphi as a Methodology for Eliciting Expert Opinion -- Important Factors to Be Considered

Purpose: The purpose of this paper is to provide a clear guideline of the application of Delphi technique in a research process.Methodology: The paper sets out a literature review of the Delphi approach which discusses both the theoretical basis and the applications of Delphi technique. Findings: The findings of this study are structured into seven sections. Apart from the introduction the proceeding sections of the paper discusses the theoretical and conceptual basis on what constitutes Delphi, Delphi questionnaire design, the administration of the Delphi survey, Delphi panel selection, analysing Delphi results, and finally a brief conclusion with vital points to be consider in using Delphi as a Decision Analysis tool. Originality: Existing literature on Delphi discusses either the theoretical concepts or an exemplification of the application of Delphi technique. This paper is an attempt to combine the theoretical basis of Delphi along with the tactical knowledge that was immerged from empirical literature on Delphi.
Clinical Features of Kawasaki Disease With Atlantoaxial Rotatory Fixation

Purpose: Atlantoaxial rotatory fixation (AARF) is a rare complication of acute Kawasaki disease (KD). Early diagnosis and intervention are important for AARF because delayed diagnoses may incur neurological sequelae. However, previous studies on AARF associated with KD are limited, and its clinical characteristics and course are unknown. This study aimed to examine the clinical features and treatment course of KD with AARF using a Japanese national inpatient database. Methods: Using the Diagnosis Procedure Combination database, we identified KD patients who received intravenous immunoglobulin (IVIG) treatment between July 2010 and March 2020. The clinical characteristics of KD patients with AARF and their risk factors were evaluated using multivariable logistic regression analysis. We also examined the relationship between AARF, the proportion of coronary artery abnormalities (CAAs), IVIG resistance, length of stay and medical costs. Results: We identified 71,913 patients with KD, 166 of whom had AARF. The AARF group had older age, heavier bodyweight and atypical KD. In multivariable analysis, AARF was associated with older age [odds ratio (OR): 1.24; 95% confidence interval (CI): 1.19–1.29], lower body mass index (OR: 0.89; 95% CI: 0.82–0.96) and atypical KD (OR: 1.95; 95% CI: 1.12–3.40). AARF was not associated with CAAs (OR: 0.73; 95% CI, 0.23–2.32) and IVIG resistance (OR: 1.05; 95% CI, 0.74–1.49). However, AARF was associated with higher medical costs (difference, US$1064; 95% CI: 346–1781) and longer hospital stay (difference, 3.1 days; 95% CI: 1.7–4.4). Conclusion: AARF in patients with acute KD should be considered if cervical symptoms present in older patients with atypical KD.
Supply Chain Climate Exposure

We propose an intuitive measure of supply chain climate risks, reflecting the fact that even a green company may have material climate exposure if its customers or suppliers face climate risks. Our measure captures price movements around climate news better than traditional climate data and shows performance patterns consistent with re-pricing of climate risks. The metric is more suitable for risk measurement than scope 3 emissions and requires raw data that is broadly accessible for large cross-sections of stocks and is of higher quality than currently available scope 3 data. We discuss applications for both portfolio and corporate decision-making.
Wheel-Running Exercise Protects Ovariectomized Mice from Bone Loss via IFN-γ-Mediated Suppression of the NF-κB and MAPK Pathways

Physical exercise is recommended as a preventative approach for osteoporosis; however, the effect of physical exercise on bone mass remains controversial. Additionally, the immune regulation of physical exercise on bone mass remains unclear. To determine whether wheel-running (WR) exercise contributes to improving bone mineral density (BMD) and investigate the involved immune mechanism, ovariectomized (OVX) and sham-operated mice were treated with 8 weeks of WR exercise. The distal femurs of the mice were sequentially scanned, reconstructed, and analyzed using microcomputed tomography and related software to assess BMD and bone microarchitecture. Flow cytometry assays were applied to investigate alterations in immune cells and inflammatory cytokines. In vitro, osteoclast differentiation was conducted to determine the effect of IFN-γ on osteoclastogenesis and the underlying mechanism. As a result, trabecular parameters were decreased in the OVX mice compared with the sham group. However, WR exercise significantly improved the deterioration in the bone microarchitecture of the OVX mice with an increase of 60.00% in BMD, 55.18% in bone volume, 66.67% in trabecular number, 32.52% in trabecular thickness, and a decrease of 19.44% in trabecular separation. Similarly, WR exercise increased the proportion of CD8+ T cells from 7.26 ± 1.71% to 10.23 ± 1.35% in the spleen and from 1.62 ± 0.54% to 2.38 ± 0.43% in the bone marrow of the OVX mice (P < 0.05). The expression of IFN-γ was also increased in the OVX + WR mice compared with the OVX mice (1.65 ± 0.45% vs. 2.26 ± 0.34%, P < 0.05). In vitro studies demonstrated an inhibitory effect of IFN-γ on osteoclastogenesis in a dose- and time-dependent manner. Meanwhile, the classical NF-κB and MAPK pathways were found to be critical in IFN-γ-mediated inhibition of osteoclast differentiation. In conclusion, our study discovered that WR exercise rescued bone loss in the OVX mice in an IFN-γ-mediated immunomodulatory manner. After WR exercise, IFN-γ expression was restored by activated CD8+ T cells, consequently leading to the inhibition of osteoclastogenesis and the recovery from bone loss through the NF-κB and MAPK pathways.
Recent Update in Pharmacological Agents for Optic Pathway Glioma

Optic pathway gliomas (OPGs) are insidious, debilitating low-grade tumors. They can affect the optic nerve, optic chiasm, and optic tracts and can be sporadic or associated with neurofibromatosis type 1 (NF1). The location of OPGs within the optic pathway typically precludes complete resection or optimal radiation dose. Treatment is unnecessary for sporadic and NF1-related OPGs that do not cause visual impairments. Chemotherapy is the mainstay of treatment for patients with progressive disease. However, outcomes following standard treatments have been mixed, and standardized outcome measurements are lacking. In recent years, newer molecularly targeted therapies such as anti-vascular endothelial growth factor (VEGF) monoclonal antibody, mitogen-activated protein kinase (MAPK) inhibitor, and mammalian target of rapamycin (mTOR) inhibitor, represent a promising treatment modality.
Computation of Resistive Wakefields for Collimators

A technique has been developed which enables the calculation of resistive particle wake effects. The technique can simply be calculated to any order, and is easy and quick to evaluate. No assumptions are made about the range of the interaction, but this is especially useful for short range effects. We show how the exact evaluation compares with various common approximations for some simple cases, and implement the technique in the Merlin and PLACET simulation programs. The extension from cylindrical to rectangular apertures is highlighted.
Does the neighbourhood of the dwelling and the real estate agency matter? Geographical differences in ethnic discrimination on the rental housing market

This study aims to investigate to which extent the ethnic and socio-economic composition of the neighbourhood is related to levels of discrimination in the rental housing market and how this is linked to theories of ethnic discrimination. Hereby, we divide the context into the neighbourhood of the dwelling and the real estate agency, using data from 2385 correspondence tests conducted among realtors in the city of Antwerp in Belgium. Regarding the neighbourhood of the dwelling, we find a tipping point at one third ethnic minorities whereafter ethnic discrimination decreases, which is in line with the perceived preference hypothesis and customer-based prejudice. A lower socio-economic composition relates to lower general invitation rates, which we describe as an elaboration of Putnam’s hunkering down hypothesis. Regarding the neighbourhood of the real estate agency, a higher percentage of ethnic minorities leads to lower general invitation rates, also referring to the hunkering down hypothesis. The socio-economic neighbourhood composition of the agency, however, has no impact.
Factors That Affect the Accumulation of Strecker Aldehydes in Standardized Wines: The Importance of pH in Oxidation

Strecker aldehydes (SA) can be formed in wine from the degradation of Strecker and, to a lesser degree, via the oxidation of higher alcohols. The objective of this article is to assess the magnitude of the differences introduced by wine compositional factors other than amino acids and Fe, in the accumulation of SA during oxidation. Eight red, two rosé and two white wines were oxidized. The accumulation of SA was analyzed. Whites and rosés presented negative accumulations for isobutyraldehyde, and in general, these wines accumulated smaller concentrations of the other SA than red wines. Only methional and phenylacetaldehyde were accumulated in all of the wines during oxidation. 2-methylbutanal and 3-methylbutanal were accumulated in 9 out of the 12 wines, whereas isobutyraldehyde was accumulated only in 5 out of the 12. 2-methylbutanal was, on average, the least accumulated aldehyde. Methional was the aldehyde formed most homogenously. Most of the observed differences can be attributed to three factors: the pH, oxidation time and native levels of Strecker aldehydes. The influence of pH was particularly intense in the cases of phenylacetaldehyde and methional. An independent test using synthetic wines with Strecker amino acids and 4-methylcatechol with different pHs (4.2, 3.5 and 2.8) was carried out in order to verify the higher pH value, the greater accumulation in SA after oxidation process. The results strongly suggest the important role played by pH in the accumulation of SA in wine oxidation.
‘Walking a fine line’: Union perspectives on partnership in nursing and midwifery workplaces

Drawing on qualitative research in the main UK unions for nurses/midwives, this article explores union reps’ views of the functioning of workplace partnership in two feminized professions working in the English National Health Service (NHS). Through the investigation of two professional unions, which despite their vitality remain under-researched, the study offers an investigation of the interactions between formal and informal partnership arrangements at the workplace level, the ways in which they intersect with the professional nature of the union context, and the deterioration of working conditions. In doing so, this article contributes to reflections on the prospects of workplace partnership for professional trade unions.
Toward Improving Working Conditions to Enhance Professionalism of Convention Workers: Focusing on the Difference between Job Satisfaction and Job Performance According to Professionalism Perception

In recent years, the importance of professionalism of convention workers has been rapidly emerging. Therefore, the purpose of this study is to establish a strategy for strengthening the professionalism of convention workers. For this, the study investigates if there are any differences in job satisfaction and job performance based on the segmented groups of professionalism perception of convention workers. The results of factor analysis showed six underlying dimensions of professionalism perception of convention workers. Cluster analysis showed that there were different segmented groups of professionalism perception: high level (cluster 1), low level (cluster 2), moderate level (cluster 3). Lastly, MANOVA showed that there were differences in job satisfaction and job performance among the segmented groups. More theoretical and practical implications are discussed in the conclusion.
Formulation and Characterization of Gum Arabic Stabilized Red Rice Extract Nanoemulsion

Interest in the utilization of plant-based bioactive compounds in foods has increased due to their biochemical activities and as alternatives in the reduction of high concentrations of chemical utilization. However, some of these additives are hydrophobic, thus being harder to disperse into the hydrophilic food matrix. Therefore, an oil-in-water nanoemulsion (RRE1-RRE10) was formulated with different concentrations of red rice extract (1–10% w/v). Nanoemulsion showed droplet sizes within the range of 157.33–229.71 nm and the best formulation (RRE5) was selected based on the creaming index which was stable to flocculation over a range of temperatures (30–90 °C), pH (2–9), and salt concentration (100–600 mM). It showed significantly improved antioxidant and anti-inflammatory activity as compared to its other counterparts. Potential antimicrobial activity against Staphylococcus aureus was attributed to RRE5 nanoemulsion as compared to Escherichia coli. Therefore, due to the potential bioactivity of RRE5 nanoemulsion, it can be scaled up at the industrial level.
The Influence of E-Ordering on Procurement Performance in Geothermal Development Company in Kenya.

The objective of this study is to establish the influence of e-ordering on procurement performance in a Geothermal Development Company in Kenya. The study adopted the technology acceptance Model theory. A descriptive research design was adopted in this study. The target population included the total number of employees working in procurement and logistics departments in the GDC Nakuru region. There are a total of 170 procurement as well as logistics employees in GDC. A multi-stage sampling method was used where 97 respondents were selected as the study respondents. Questionnaires were used to collect primary data. The instrument was tested for validity and reliability where Cronbach's alpha was used to test the reliability of the instrument. The alpha values for all the variables were above 0.8 well above the recommended threshold of 0.7. Thus the instruments were deemed reliable for data collection in the study. Data collected was analysed using Statistical Package for Social Sciences (SPSS). Findings were presented in form of descriptive statistics and inferential statistics and presented in tables accompanied with relevant discussion. The study established that e-ordering had a positive (r=.634) significant relationship with procurement performance in the geothermal development companies. This study, therefore, concluded that e-ordering was demonstrated to greatly enhance procurement performance in Geothermal Development Company. The study recommends that the company should exploit the use of online platforms in placing their orders for suppliers to enhance their order efficiency and enhance procurement performance.
Production, Characterization, and Molecular Phylogenetic Analysis of Phytase from Aspergillus niger Isolates of an Indonesia Origin

This research aimed at analyzing the phytase from fungal isolates SB1, SB2, BS, and WF produced in cornstarch with glucose medium (CS+Glu) as carbon sources and Potatoes dextrose broth (PDB). The activity of phytase from isolates SB1, SB2, BS, and WF produced in CS+Glu medium was 2.97 UmL-1, 2.87 UmL-1, 3.18 UmL-1, and 4.37 UmL-1, respectively, while the activity of phytases was 2.07 UmL-1, 2.17 UmL-1, 2.22 UmL-1, and 2.78 UmL-1 respectively in PDB medium. The optimal temperature of SB1 and WF phytase was 40°C, while SB2 and BS were 50°C and 60°C, respectively. The optimal pH of SB1 and WF phytase was 5.0, while SB2 and BS phytase were 6.0, and 4.0 respectively. 18S rRNA gene analysis revealed that SB1 was 99% identical to Aspergillus niger ANTS (KY825168.1), SB2, BS, and WF were 99% identical to A. niger Moriga leaf (MG889596.1). Multiple sequences and phylogenetic analysis of phytase gene showed that phyA_SB1 and phyA_SB2 were 98% homology with A. ficuum (AAB26466), 97% with A. niger (ADP05107) while phyA_WF was 99% with A. ochraceoroseus (PLB29348), 98% with A. niger (ADP05105). The deduced proteins contain conserved motifs RHGARYPTD at N-terminal while lacking HD motif at C-terminal. These phytases were in the same cluster with Aspergillus sp. phytase A indicating that they belong to Histidine Acid Phosphatases (HAP) family.