Miracle-dz/UniFAR-FTUs huggingface dataset:
Serum Lactate Dehydrogenase Is a Sensitive Predictor of Systemic Complications of Acute Pancreatitis

Background Acute pancreatitis (AP) is a common and potentially life-threatening inflammatory disease that can cause various complications, including systemic inflammatory response syndrome (SIRS), pleural effusion, ascitic fluid, myocardial infarction, and acute kidney injury (AKI). However, there is still a lack of rapid and effective indicators to assess the disease. The aim of this study was to investigate the associations of high serum lactate dehydrogenase (LDH) levels with AP severity and systemic complications. Methods AP patients treated from July 2014 to December 2020 were retrospectively enrolled. They were divided into elevated (n = 93) and normal (n = 143) LDH groups. Their demographic data, clinical data, hospital duration, and hospital expenses were analyzed. Linear and binary logistic regression analyses were used to determine whether elevated LDH is a risk factor for AP severity and complications after adjusting for confounders. Results There were significant differences in AP severity scores (Ranson, MODS, BISAP, APACHE II, and CTSI), hospital duration, hospital expenses, and the incidences of complications (SIRS, pleural effusion, ascitic fluid, myocardial infarction, and AKI) between the elevated and normal LDH groups. After adjusting for confounders, elevated LDH was associated with AP severity scores and hospital duration and expenses (based on linear regression analyses) and was a risk factor for the occurrence of AP complications and interventions, that is, diuretic and vasoactive agent use (based on binary logistic regression analyses). Conclusions Elevated LDH is associated with high AP severity scores and high incidences of complications (SIRS, pleural effusion, ascitic fluid, myocardial infarction, and AKI).
3D Printed Fractal-like Structures with High Percentage of Drug for Zero-Order Colonic Release

Colonic drug delivery of drugs is an area of great interest due to the need to treat high prevalence colonic local diseases as well as systemic conditions that may benefit from the advantages associated to this route of drug administration. In the last decade, the use of 3D printing technologies has expanded, offering the possibility of preparing personalized medicines in small batches directly at the point of care. The aim of this work is to design a high drug loaded 3D printed system prepared by a combination of Fused Deposition Modelling (FDM) and Injection Volume Filling (IVF) techniques intended for zero-order colonic drug release. For this purpose, different batches of binary and ternary filaments based on the thermoplastic polyurethane Tecoflex EG-72D (TPU), theophylline anhydrous (AT) as model drug, and magnesium stearate as lubricant have been developed and characterized. Filaments with the highest drug load and the best rheological properties were selected for the manufacture of a printed fractal-like structure based on multiple toroids. This design was proposed to provide high surface area, leading to increased drug release and water uptake in the colonic region. This structure was 3D printed by FDM and then coated in a unique step by IVF technology using the enteric polymer DrugCoat S 12.5. This way, an additional coating process is avoided, reducing costs and production time. Studies of drug release confirmed the ability of the structures to provide a five-hour period of constant drug delivery in the colonic region.
CCD Photometry and Spectroscopy of 14 IRAS Sources having Far-IR Colours Similar to Planetary Nebulae

CCD imaging and BVRI photometry of 14 IRAS sources with far-IR colours similar to planetary nebulae and post-AGB stars are presented. Also results of optical and near-IR spectroscopy of 10 of these candidates are given. Based on the spectral energy distribution from 0.4 μm to 100 μm, the sample of program stars are put into two groups. The sources IRAS 08187-1905, IRAS 05238-0626 and IRAS 17086-2403 present similar flux distributions. These three sources have detached cold dust components with dust radii R d ≈ 1000 R*. The low infrared variability of theses sources suggests that the intense mass loss has been ceased. All three sources are at high galactic latitude (1>9°) suggesting that these are old low-mass evolved stars. In the IRAS colour-colour diagram of Likkel et al (1991) these sources fall in the region where most of the stars are evolved stars and PNe but without CO detection. This is consistent with at least one source IRAS 17086-2403, in which OH and CO molecular features are not detected. The far-IR excess, non-variability and high latitude of these objects suggest that these are post-AGB supergiants, slowly evolving towards planetary nebula phase.
The prevalence of type III disc breaks in H i-rich and low-spin galaxies

We investigate the origin of the type III (up-bending) discs based on a sample of 1808 galaxies from Sloan Digital Sky Survey and a sub-sample of 286 galaxies with HI data from ALFALFA. We examine how the type III fraction f(III), the fraction of disc galaxies which host up-bending disc breaks, depends on other galactic properties. We confirm that fIII strongly depends on the stellar concentration of galaxies. We find that HI-rich galaxies with low spins tend to have significantly more type III disc breaks than control galaxies, which are matched in concentration and stellar mass. This trend is independent of the existence of strong bars or environment of the galaxies. This result is broadly consistent with predictions from theoretical simulations, and indicates in situ star formation fuelled by gas accretion to be an important mechanism that builds the outer discs of type III galaxies.
The Effect of Ionic Composition on Acoustic Phonon Speeds in Hybrid Perovskites from Brillouin Spectroscopy and Density Functional Theory

Hybrid organic-inorganic perovskites (HOIPs) have recently emerged as highly promising solution-processable materials for photovoltaic (PV) and other optoelectronic devices. HOIPs represent a broad family of materials with properties highly tuneable by the ions that make up the perovskite structure as well as their multiple combinations. Interestingly, recent high-efficiency PV devices using HOIPs with substantially improved long-term stability have used combinations of different ionic compositions. The structural dynamics of these systems are unique for semiconducting materials and are currently argued to be central to HOIPs stability and charge-transport properties. Here, we studied the impact of ionic composition on phonon speeds of HOIPs from Brillouin spectroscopy experiments and density functional theory calculations for FAPbBr$_3$, MAPbBr$_3$, MAPbCl$_3$, and the mixed halide MAPbBr$_{1.25}$Cl$_{1.75}$. Our results show that the acoustic phonon speeds can be strongly modified by ionic composition, which we explain by analysing the lead-halide sublattice in detail. The vibrational properties of HOIPs are therefore tuneable by using targeted ionic compositions in the perovskite structure. This tuning can be rationalized with non-trivial effects, for example, considering the influence of the shape and dipole moment of organic cations. This has an important implication to further improvements in the stability and charge-transport properties of these systems.
Floquet theory of the analytical solution of a periodically driven two-level system

ABSTRACT We investigate the analytical solution of a two-level system subject to a monochromatical, linearly polarized external field that was first published in 2007. In particular, we derive an explicit expression for the quasienergy. Moreover, we calculate the time evolution of a typical two-level system over a full period by evaluating series solutions of the confluent Heun equation. This is possible without invoking the connection problem of this equation since the complete time evolution of the system under consideration can be reduced to that of the first quarter-period. As a physical application we consider the work performed on a two-level system.
The Near-infrared Transmission Spectra of TRAPPIST-1 Planets b, c, d, e, f, and g and Stellar Contamination in Multi-epoch Transit Spectra

The seven approximately Earth-sized transiting planets in the TRAPPIST-1 system provide a unique opportunity to explore habitable- and nonhabitable-zone small planets within the same system. Its habitable-zone exoplanets—due to their favorable transit depths—are also worlds for which atmospheric transmission spectroscopy is within reach with the Hubble Space Telescope (HST) and James Webb Space Telescope (JWST). We present here an independent reduction and analysis of two HST Wide Field Camera 3 (WFC3) near-infrared transit spectroscopy data sets for six planets (b through g). Utilizing our physically motivated detector charge-trap correction and a custom cosmic-ray correction routine, we confirm the general shape of the transmission spectra presented by de Wit et al. Our data reduction approach leads to a 25% increase in the usable data and reduces the risk of confusing astrophysical brightness variations (e.g., flares) with instrumental systematics. No prominent absorption features are detected in any individual planet’s transmission spectra; by contrast, the combined spectrum of the planets shows a suggestive decrease around 1.4 μm similar to an inverted water absorption feature. Including transit depths from K2, the SPECULOOS-South Observatory, and Spitzer, we find that the complete transmission spectrum is fully consistent with stellar contamination owing to the transit light source effect. These spectra demonstrate how stellar contamination can overwhelm planetary absorption features in low-resolution exoplanet transit spectra obtained by HST and JWST and also highlight the challenges in combining multi-epoch observations for planets around rapidly rotating spotted stars.
Explicit formula for the solution of the Szeg

We consider the cubic Szeg\"o equation i u_t=Pi(|u|^2u) in the Hardy space on the upper half-plane, where Pi is the Szeg\"o projector on positive frequencies. It is a model for totally non-dispersive evolution equations and is completely integrable in the sense that it admits a Lax pair. We find an explicit formula for solutions of the Szeg\"o equation. As an application, we prove soliton resolution in H^s for all s>0, for generic data. As for non-generic data, we construct an example for which soliton resolution holds only in H^s, 0 1/2. As a second application, we construct explicit generalized action-angle coordinates by solving the inverse problem for the Hankel operator H_u appearing in the Lax pair. In particular, we show that the trajectories of the Szeg\"o equation with generic data are spirals around Lagrangian toroidal cylinders T^N \times R^N.
c2d Spitzer IRS Spectra of Disks around T Tauri Stars. I. Silicate Emission and Grain Growth

Infrared ~5-35 μm spectra for 40 solar mass T Tauri stars and 7 intermediate-mass Herbig Ae stars with circumstellar disks were obtained using the Spitzer Space Telescope as part of the c2d IRS survey. This work complements prior spectroscopic studies of silicate infrared emission from disks, which were focused on intermediate-mass stars, with observations of solar mass stars limited primarily to the 10 μm region. The observed 10 and 20 μm silicate feature strengths/shapes are consistent with source-to-source variations in grain size. A large fraction of the features are weak and flat, consistent with micron-sized grains indicating fast grain growth (from 0.1 to 1.0 μm in radius). In addition, approximately half of the T Tauri star spectra show crystalline silicate features near 28 and 33 μm, indicating significant processing when compared to interstellar grains. A few sources show large 10-to-20 μm ratios and require even larger grains emitting at 20 μm than at 10 μm. This size difference may arise from the difference in the depth into the disk probed by the two silicate emission bands in disks where dust settling has occurred. The 10 μm feature strength versus shape trend is not correlated with age or Hα equivalent width, suggesting that some amount of turbulent mixing and regeneration of small grains is occurring. The strength versus shape trend is related to spectral type, however, with M stars showing significantly flatter 10 μm features (larger grain sizes) than A/B stars. The connection between spectral type and grain size is interpreted in terms of the variation in the silicate emission radius as a function of stellar luminosity, but could also be indicative of other spectral-type-dependent factors (e.g., X-rays, UV radiation, and stellar/disk winds).
New Binaries in the ϵ Cha Association

We present Adaptive Optics-aided speckle observations of 47 young stars in the ϵ Cha association made at the 4 m Southern Astrophysical Research Telescope in the I-band. We resolved 10 new binary pairs, 5 previously known binaries, and 2 triple systems, also previously known. In the separation range between 4 and 300 au, the 30 association members of spectral types G0 and later host 6 binary companions, leading to the raw companion frequency of 0.010 ± 0.04 per decade of separation, comparable to the main sequence dwarfs in the field. On the other hand, all five massive association members of spectral types A and B have companions in this range. We discuss the newly resolved and known binaries in our sample. Observed motions in the triple system ϵ Cha, composed of three similar B9V stars, can be described by tentative orbits with periods 13 and ∼900 years and a large mutual inclination.
Noninferiority Randomized Controlled Trials METHODS AND TECHNIQUES FOR SKIN RESEARCH

From 2005 to 2015, the publication of noninferiority trials increased by six-fold. Noninferiority trials assess whether a new treatment’s efﬁcacy is comparable with that of the standard of care and have several ap-peals. Noninferiority trials can evaluate for both noninferiority and superiority of a new treatment. In addition, multiple treatment modalities exist, and new treatments may be advantageous for reasons beyond efﬁcacy. Common elements of trial design such as the research question, outcomes, statistical analysis, and interpretation of results differ meaningfully between noninferiority trials and superiority trials. The noninferiority margin, constancy assumption, and assay sensitivity are unique aspects of noninferiority trials. As with all randomized controlled trials, patient engagement in and reporting of noninferiority trials are also important. In this review, we discuss the methodological considerations and limitations of noninferiority trials.
From Serendipity to Rational Identification of the 5,6,7,8-Tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one Core as a New Chemotype of AKT1 Inhibitors for Acute Myeloid Leukemia

Acute myeloid leukemia (AML) is a heterogeneous hematopoietic malignancy whose prognosis is globally poor. In more than 60% of AML patients, the PI3K/AKTs/mTOR signaling pathway is aberrantly activated because of oncogenic driver alterations and further enhanced by chemotherapy as a mechanism of drug resistance. Against this backdrop, very recently we have started a multidisciplinary research project focused on AKT1 as a pharmacological target to identify novel anti-AML agents. Indeed, the serendipitous finding of the in-house compound T187 as an AKT1 inhibitor has paved the way to the rational identification of new active small molecules, among which T126 has emerged as the most interesting compound with IC50 = 1.99 ± 0.11 μM, ligand efficiency of 0.35, and a clear effect at low micromolar concentrations on growth inhibition and induction of apoptosis in AML cells. The collected results together with preliminary SAR data strongly indicate that the 5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one derivative T126 is worthy of future biological experiments and medicinal chemistry efforts aimed at developing a novel chemical class of AKT1 inhibitors as anti-AML agents.
Language-guided Task Adaptation for Imitation Learning

We introduce a novel setting, wherein an agent needs to learn a task from a demonstration of a related task with the difference between the tasks communicated in natural language. The proposed setting allows reusing demonstrations from other tasks, by providing low effort language descriptions, and can also be used to provide feedback to correct agent errors, which are both important desiderata for building intelligent agents that assist humans in daily tasks. To enable progress in this proposed setting, we create two benchmarks -- Room Rearrangement and Room Navigation -- that cover a diverse set of task adaptations. Further, we propose a framework that uses a transformer-based model to reason about the entities in the tasks and their relationships, to learn a policy for the target task
OP-BRAI170144 2157..2168

Cognitive deficits are common among epilepsy patients. In these patients, interictal epileptiform discharges, also termed spikes, are seen routinely on electroencephalography and believed to be associated with transient cognitive impairments. In this study, we investigated the effect of spikes on memory encoding and retrieval, taking into account the spatial distribution of spikes in relation to the seizure onset zone as well as anatomical regions of the brain. Sixty-seven patients with medication refractory epilepsy undergoing continuous intracranial electroencephalography monitoring engaged in a delayed free recall task to test short-term memory. In this task, subjects were asked to memorize and recall lists of common nouns. We quantified the effect of each spike on the probability of successful recall using a generalized logistic mixed model. We found that in patients with left lateralized seizure onset zones, spikes outside the seizure onset zone impacted memory encoding, whereas those within the seizure onset zone did not. In addition, spikes in the left inferior temporal gyrus, middle temporal gyrus, superior temporal gyrus, and fusiform gyrus during memory encoding reduced odds of recall by as much as 15% per spike. Spikes also reduced the odds of word retrieval, an effect that was stronger with spikes outside of the seizure onset zone. These results suggest that seizure onset regions are dysfunctional at baseline, and support the idea that interictal spikes disrupt cognitive processes related to the underlying tissue.
Deterministic assembly and anthropogenic extinctions drive convergence of island bird communities

Aim: Whether entire communities of organisms converge towards predictable structural properties in similar environmental conditions remains controversial. We tested for community convergence in birds by comparing the structure of oceanic archipelago assemblages with their respective regional species pools. Methods: We compiled a comprehensive database of morphological trait and phylogenetic data for 6,579 bird species, including species known to have become extinct owing to human activities. We quantified morphological and phylogenetic dissimilarity among species between pairs of archipelagos, using a modified version of the mean nearest taxon distance. We tested for convergence by estimating whether overall mean turnover among archipelagos and pairwise turnover between archipelagos were lower than expected by chance. the of endemic Our results highlight the potential role of non- random extinction in generating patterns of community convergence and show that convergence existed even before extinctions, owing to deterministic community assembly in similar environmental settings at the global scale.
Twisted states in low-dimensional hypercubic lattices

Twisted states with non-zero winding numbers composed of sinusoidally coupled identical oscillators have been observed in a ring. The phase of each oscillator in these states constantly shifts, following its preceding neighbor in a clockwise direction, and the summation of such phase shifts around the ring over $2\pi$ characterizes the winding number of each state. In this work, we consider finite-sized $d$-dimensional hypercubic lattices, namely square ($d=2$) and cubic ($d=3$) lattices with periodic boundary conditions. For identical oscillators, we observe new states in which the oscillators belonging to each line (plane) for $d=2$ ($d=3$) are phase synchronized with non-zero winding numbers along the perpendicular direction. These states can be reduced into twisted states in a ring with the same winding number if we regard each subset of phase-synchronized oscillators as one single oscillator. For nonidentical oscillators with heterogeneous natural frequencies, we observe similar patterns with slightly heterogeneous phases in each line $(d=2)$ and plane $(d=3)$. We show that these states generally appear for random configurations when the global coupling strength is larger than the critical values for the states.
Polynomial Poisson algebras : Gel'fand-Kirillov problem and Poisson spectra

We study the fields of fractions and the Poisson spectra of polynomial Poisson algebras. First we investigate a Poisson birational equivalence problem for polynomial Poisson algebras over a field of arbitrary characteristic. Namely, the quadratic Poisson Gel'fand-Kirillov problem asks whether the field of fractions of a Poisson algebra is isomorphic to the field of fractions of a Poisson affine space, i.e. a polynomial algebra such that the Poisson bracket of two generators is equal to their product (up to a scalar). We answer positively the quadratic Poisson Gel'fand-Kirillov problem for a large class of Poisson algebras arising as semiclassical limits of quantised coordinate rings, as well as for their quotients by Poisson prime ideals that are invariant under the action of a torus. In particular, we show that coordinate rings of determinantal Poisson varieties satisfy the quadratic Poisson Gel'fand-Kirillov problem. Our proof relies on the so-called characteristic-free Poisson deleting derivation homomorphism. Essentially this homomorphism allows us to simplify Poisson brackets of a given polynomial Poisson algebra by localising at a generator. Next we develop a method, the characteristic-free Poisson deleting derivations algorithm, to study the Poisson spectrum of a polynomial Poisson algebra. It is a Poisson version of the deleting derivations algorithm introduced by Cauchon [8] in order to study spectra of some noncommutative noetherian algebras. This algorithm allows us to define a partition of the Poisson spectrum of certain polynomial Poisson algebras, and to prove the Poisson Dixmier-Moeglin equivalence for those Poisson algebras when the base field is of characteristic zero. Finally, using both Cauchon's and our algorithm, we compare combinatorially spectra and Poisson spectra in the framework of (algebraic) deformation theory. In particular we compare spectra of quantum matrices with Poisson spectra of matrix Poisson varieties.