Miracle-dz/UniFAR-FTUs huggingface dataset:
Transcriptome sequencing of Pinus massoniana rooted and non-rooted cuttings

Pinus massoniana Lamb. is a unique and fat-producing tree species growing in southern China. However, cuttings of this species are difficult to root. In this study, transcriptome sequencing of rooted and non-rooted cuttings of this species was performed by Illumina sequencing technology. We obtained 138,466,788 raw reads and 132,448,884 clean reads including 124,396 unigenes after de novo assembly; these unigenes were annotated into seven databases. In the rooted and non-rooted cuttings, 781 differentially expressed genes (DEGs) were found, of which 368 were up-regulated and 413 were downregulated. The Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis indicated that these DEGs were enriched in 73 pathways, 18 of which were significantly enriched, including ‘photosynthesis’, ‘phenylpropanoid biosynthesis’, ‘starch and sucrose metabolism’, and ‘carbon fixation in photosynthetic organisms’. ‘Plant hormone signal transduction’ was involved in the regulation of endogenous hormones, including some genes related to indole acetic acid (IAA) that were significantly associated with rooting. These genes were also found in the rooting processes of other plants. Compared with the non-rooted Pinus massoniana seedlings, auxin-responsive protein (AUX/IAA) was significantly downregulated in the rooting shoots. We selected 10 genes from the DEGs and performed real-time quantitative polymerase chain reaction (RT-qPCR) verification. The results were consistent with the gene expression based on the RNA-seq technology. Our study may be useful for improving the rooting rate of Pinus massoniana cuttings.
PROFILE OF HOSPITALIZED PATIENTS IN ADULT INTENSIVE CARE UNIT

The Intensive Care Unit (ICU) was developed in the 20th century, on the need to recover / stabilize seriously wounded patients. With the increasing life expectancy, the raise on chronic diseases and high complexity treatments, as well as invasive procedures, the ICU comes with a more qualified life bearer. The ICU is the appropriate place to recoverable severe patients, who need assistance and monitoring 24 hours a day. The aim of this research is to characterize the profile of patients hospitalized in the Intensive Care Unit of a hospital in Cascavel/PR. It was a quantitative, documental study of descriptive and retrospective approach. 296 medical records were studied from January to April 2015. The observed variables in this study were gender, age, city of origin, length of stay, main causes for hospitalization, release / death. Among the main findings, there is the prevalence of males, in both cases, number of ICU admissions and number of deaths. The main cause of death for women and men was the cardiovascular diseases and expressive prevalence of elderly, representing 66.55% of total admissions. The characterization of ICU patients can aid in the guidelines of admissions and releases of this unit, as the knowledge of critical patients' profile favors the establishment of objective criteria for this end, helping all multidiscipline team.
Examining the effect of Positive Psychology Interventions to improve psychological wellbeing, workplace motivation and re-employment prospects in North Wales

Objective: Satisfaction of one’s psychological needs, as defined by Self-Determination Theory (SDT), has previously been implicated as a determining factor in evidenced beneficial increases in wellbeing and intrinsic motivation. Increasing intrinsic motivation is vital in the workplace as improved task-performance, enhanced motivational persistence and the development of an internal locus of control are observed as a consequence. To develop this type of motivation, a particular focus is placed within SDT on an organismic dialectical approach. Here, significance is placed not only on the optimum environmental constraints that lead to the development of intrinsic motivation, but also one’s innate drive to optimal functioning. As the workplace provides an environment with an equal emphasis on reward systems and opportunities for personal growth, it was hypothesised that SDT provides the ideal conceptualisation of intrinsic motivation in this context. Due to research which evidences the value of positive daily reflection, the aim of Study 1 was to develop a novel SDT Diary which placed a focus on daily satisfaction of these psychological needs. Design: A Mixed Measures design was employed; participants were randomly allocated to either an SDT Diary condition or placebo control and measured at three time points (pre-, post-test and follow-up). Participants engaged with their allocated diary for one-week. Participants: Over two studies, the final sample totalled 139 Higher Education Students. Measures: In both studies, participants completed self-report measures of intrinsic motivation, basic psychological need satisfaction (and need frustration in Study 1b) and wellbeing. Results: Across two studies, a series of Mixed Measures ANOVAs evidenced no significant beneficial effects. Conclusion: Findings suggest that placing an explicit focus on and reflecting upon the fulfilment of one’s psychological needs does not significantly impact upon self-reported intrinsic motivation and wellbeing. Chapter 2: Development of an SDT diary. 40
THE NIGERIAN JOURNAL OF SOCIOLOGY AND ANTHROPOLOGY

This paper examined the influence of sociocultural factors such as beliefs and practices on medication use among stroke patients in rural Cross River State, Nigeria as a way understand the health-seeking behaviour of these patients in the area. The Predisposing-Enabling-Need and Witchcraft Theories of disease causation provided the framework. Data collection was through three qualitative methods. Thirty in-depth interviews were conducted with six key opinion leaders (chiefs, elders and religious leaders), six care givers, six significant others, and 12 stroke patients. Eighteen Focus Group Discussions were conducted among men, women, community leaders and community members, while two life histories were carried out on stroke patients. Results indicated that beliefs and practices were significantly associated with medication use among stroke patients. Stroke was perceived as caused by supernatural forces working through human agencies, breach of religious taboos, and violation of social norms. As a result, the majority of the respondents and participants perceived traditional medicine essentially as the most important treatment option.
Sedimentary and tectonic controls on Lower Carboniferous (Visean) mixed carbonate–siliciclastic deposition in NE England and the Southern North Sea: implications for reservoir architecture

Discovery of the Breagh gas field in the Southern North Sea (SNS) has demonstrated the potential that the Lower Carboniferous (Visean, 346.7–330.9 Ma) Farne Group reservoirs have to contribute to the UK's future energy mix. New biostratigraphic correlations provide a basis to compare Asbian and Brigantian sedimentary cores from the Breagh Field and age-equivalent sediments exposed on the Northumberland Coast, which has proved critical in gaining an understanding of exploration and development opportunities. Thirteen facies associations characterize the mixed carbonate–siliciclastic system, grouped into: marine, delta front, delta shoreface, lower delta plain and upper delta plain gross depositional environments. The facies associations are interpreted as depositing in a mixed carbonate and siliciclastic fluvio-deltaic environment, and are arranged into coarsening- and cleaning-upward cycles (parasequences) bounded by flooding surfaces. Most cycles are characterized by mouth bars, distributary channels, interdistributary bays and common braided rivers, interpreted as river-dominated deltaic deposits. Some cycles include rare shoreface and tidally-influenced deposits, interpreted as river-dominated and wave- or tide-influenced deltaic deposits. The depositional processes that formed each cycle have important implications for the reservoir net/gross ratio (where this ratio indicates the proportion of sandstone beds in a cycle), thickness and lateral extent. The deltaic deposits were controlled by a combination of tectonic and eustatic (allocyclic) events and delta avulsion (autocyclic) processes, and are likely to reflect a changing tectonic regime, from extension within elongate fault-bounded basins (synrift) to passive regional thermal subsidence (post-rift). Deep incision by the Base Permian Unconformity across the Breagh Field has removed the Westphalian, Namurian and upper Visean, to leave the more prospective thicker clastic reservoirs within closure. Thematic collection: This article is part of the Under-explored plays and frontier basins of the UK continental shelf collection available at: https://www.lyellcollection. org/cc/under-explored-plays-and-frontier-basins-of-the-uk-continental-shelf
L’influence modératrice de la performance environnementale sur le lien entre communication RSE et performance boursière

L’article analyse la relation entre communication environnementale et performance boursiere en prenant en consideration l’effet moderateur de la performance environnementale. Cette relation a donne lieu a de nombreuses publications academiques et empiriques qui aboutissent a des resultats contrastes. En effet, la divulgation environnementale est critiquee par les parties prenantes dans la mesure ou sa finalite est uniquement la recherche de legitimite pour assurer la survie de l’entreprise. Ceci les conduit a s’interroger sur la credibilite percue des informations environnementales publiees volontairement par les entreprises. Les auteurs abordent cette question importante en s’appuyant sur une recherche conduite aupres de 91 entreprises francaises, qui met en avant le role de la performance environnementale comme facteur cle conditionnant les benefices qu’une entreprise peut esperer tirer d’une politique active de communication environnementale aupres des actionnaires.
Vocalisation in Group Writing: A New Proposal

The so-called group writing or syllabic orthography is a special orthography used in Egyptian hieroglyphic texts starting from the New Kingdom/Late Bronze Age. The nature and function of this orthography, especially the way it notates vowels, has been a topic of debate for more than a century, without any consensus being reached. In this book, Marwan Kilani presents a new interpretative model that provides a fresh explanation of how the syllabic orthography notates vowels. The author starts from a critical reanalysis of previous suggestions and from a thorough reassessment of the evidence. He then infers the functioning of the system by comparing the group writing spelling of Late Egyptian words surviving in Coptic with the reconstructions of their vocalizations. This approach leads to the recognition of a system that not only coherently explains all the spellings attested in the corpus, but which also produces interpretations of the spellings in group writing that agree with current reconstructions of the Egyptian vocalization. The book contains indexes and an Appendix listing the words analysed in the study.
A Survey of Statistical Studies on the Prevalence and Incidence of Mental Disorder in Sample Populations

Intelligent planning for action in the field of mental hygiene requires knowledge of the magnitude of the problem. It is therefore necessary to ascertain the prevalence and incidence of mental hygiene problems in the general population. "Prevalence" is understood as referring to the number of cases active at a given moment, "incidence" to the number of new cases occurring either during an arbitrary period, usually a year, or during the life span of a group of individuals. In the latter case the rates are often referred to as "expectancies. " Attempts at complete enumeration of mental deviants have been made at various times in many countries in connection with the national censuses. Such attempts have been generally unsuccessful because of widespread failure on the part of informants and enumerators to recognize or report any but the most obvious cases. Machinery for the general reporting of new cases of mental disorder does not exist in any country and for obvious reasons is not likely to be established. It is believed that in communities with an adequate and well established system of mental hospitals most psychotics find their way into these hospitals at some time during their lives, even though they spend a considerable part of their period of illness on the outside. For such populations rates of first admissions have been used as a substitute for incidence rates (18, 28, 32, 41). This method however, is not suitable for forms of mental disorder which do not as a rule require or receive institutional care. The difficulties standing in the way of even approaching complete coverage of all cases of mental disorder in any large geographical-or political unit have thus far proved insurmountable. The only practicable way yet discovered to approach the problem is to gather
Health and nutritional status of Korean adults according to age and household food security: Using the data from 2010~2012 Korea National Health and Nutrition Examination Survey

본 연구는 2010~2012년 국민건강영양조사에 참여한 20~79세 한국 성인 총 16,595명을 대상으로 식품안정성에 따른 건강 및 영양섭취상태를 살펴보았다. 식품안정성 문항의 답변에 따라 Secure군은 7,256명 (43.7%), Mildly insecure군은 8,764명 (52.8%), Moderately/Securely insecure 군은 575명 (3.5%) 이었다. 식품불안정은 나이가 많을수록, 여성일수록, 교육 및 소득 수준이 낮을수록, 독거인 경우, 체질량지수, 현재 흡연율, 운동유무, 직업에 따라 유의한 차이를 보였다. 또한 20~39세 그룹에서 식품불안정성이 높은 군일수록 헤모글로빈은 낮았고, 철결합능은 높았으며, 40~59세 그룹에서 식품불안정성이 높은 군일수록 HDL-콜레스테롤이 낮았으며, 60~79세 그룹에서 식품불안정성이 높은 군일수록 총 콜레스테롤이 높게 측정되었다. 식품안정성이 불안정할수록 20~39세 남자에서는 수면시간이 적었고, 40~59세 남자에서는 우울증상과 자살을 생각해본 비율이 높았고 60~79세 남자는 수면시간이 많았고 스트레스를 많이 느끼고 우울증상과 자살을 생각해 본 대상자의 비율이 높았다. 또한 식품안정성이 불안정한 여성은 40~59세, 60~79세 공통적으로 스트레스를 많이 느끼며 우울증상과 자살생각과 같은 정신건강과 밀접한 관련이 있었다. 영양소 섭취량은 식품불안정이 높은 그룹일수록 전체적인 영양소 섭취량이 낮은 경향을 보였고, 전반적으로 20~39세 그룹에서는 Secure군과 Mildly insecure군의 섭취에는 유의적인 차이가 없는 반면, 40~59세, 60~79세 그룹에서는 세 그룹 간에 유의적인 차이가 있었다. 또한 식품섭취량은 모든 그룹에서 식품불안정이 높은 그룹일수록 전반적인 식품섭취는 감소하는 경향을 보였다. 본 연구 결과 우리나라 성인의 식품안정성은 나이, 성별, 교육, 소득수준, 독거 유무, 직업 특성 및 활동 가능성 여부 등과 관련이 있으며 식품안정성은 식품섭취와 영양소 섭취뿐만 아니라 스트레스, 우울증, 자살생각과 성인의 정신건강과 밀접한 관련이 있었다. 한국 성인 및 노인에게 식품불안정이 신체적 및 정신적 건강상태와 식이섭취상태를 악화시키는 요인으로 나타났다. 본 연구에서는 젊은 성인보다 중년과 노인이 식품불안정에 따른 건강에 더 취약한 것으로 나타나 연령에 따라 식품안정성과 건강을 확보하기 위한 다양한 정책과 영양지원 프로그램이 필요함을 확인하였다.
Scientific Opinion on the safety and suitability for use by infants of follow‐on formulae with a protein content of at least 1.6 g/100 kcal

Abstract Following a request from the European Commission, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to deliver a scientific opinion on the safety and suitability for use by infants of follow‐on formulae (FOF) based on cow's milk intact protein with a protein content of at least 1.6 g/100 kcal (rounded value) that meet otherwise the requirements of relevant EU legislation. If the formula under evaluation is considered to be safe and suitable for use by infants, the NDA Panel is also asked to advise on whether FOF based on goat's milk intact protein, soy protein isolates or protein hydrolysates are also safe and suitable for infants under the same conditions. The Panel concludes that the use of FOF with a protein content of at least 1.6 g/100 kcal from either intact cow's milk protein or intact goat's milk protein otherwise complying with the requirements of relevant EU legislation is safe and suitable for healthy infants living in Europe with an intake of complementary foods of a sufficient quality. This conclusion does not apply to infant formula (IF). The Panel also concludes that the safety and suitability of FOF with a protein content of at least 1.6 g/100 kcal manufactured from either protein hydrolysates or soy protein isolates cannot be established with the available data. The same conclusion applies to IF. The NDA Panel endorsed a draft of this scientific opinion on 14 December 2016 for public consultation. The draft document has been revised and updated according to the comments received, where appropriate.
Study of antibiotic susceptibility pattern of Salmonella typhi in children suffering from enteric fever

Background: Due to the lack of sanitation measures and clean water, typhoid fever is prevalent in developing countries such as India. Also, increasing cases of antibiotic resistance as well as multiple drug resistance (MDR) have been reported in Indian subcontinents. However, there is inadequate data available on the antibiotic sensitivity pattern of Salmonella enterica serovar Typhi (S. typhi) among children in Indian subcontinents. Materials and Methods: A total of 43 isolates of S. typhi were collected from the blood samples of children in the age group of 3-12 years and further were tested for antimicrobial susceptibility according to the CLSI guidelines. Results: Of the total isolates studied, 44% were found to be multidrug resistant (MDR) (defined as resistance against more than one group of antibiotic). The isolates showed the highest resistance against aminoglycoside antibiotics and least against carbapenem antibiotics. Conclusion: The presence of MDR S. typhi imposes a serious concern about the drug of choice for treatment of typhoid fever in children. A careful consideration should be given before deciding the antibiotic for treatment in order to prevent the emergence of antibiotic resistance.
Screening of FDA-Approved Drugs Using a MERS-CoV Clinical Isolate from South Korea Identifies Potential Therapeutic Options for COVID-19

Therapeutic options for coronavirus remain limited. To address this unmet medical need, we screened 5,406 compounds, including United States Food and Drug Administration (FDA)- approved drugs and bioactives, for activity against a South Korean Middle East respiratory syndrome coronavirus (MERS-CoV) clinical isolate. Among 221 identified hits, 54 had therapeutic indexes (TI) greater than 6. Time-of-addition studies with selected drugs demonstrated eight and four FDA-approved drugs acted on the early and late stages of the viral life cycle, respectively. Confirmed hits included several cardiotonic agents (TI>100), atovaquone, an anti-malarial (TI>34), and ciclosonide, an inhalable corticosteroid (TI>6). Furthermore, utilizing the severe acute respiratory syndrome CoV-2 (SARS-CoV-2), combinations of remedesivir with selected dugs were evaluated, which identified ciclosonide and nelfinavir to be additive and synergistic drugs in vitro, respectively. Together, we screened FDA-approved drugs using patient-derived MERS-CoV, triaged hits to discriminate between early and late viral life cycle inhibitors, confirmed selected drugs using SARS-CoV-2, and demonstrated the added value of selected medications in combination with remedesivir. Our results identify potential therapeutic options for MERS-CoV infections, and provide a basis to treat coronavirus disease 2019 (COVID-19) and other coronavirus-related illnesses.
Escort-like somatic cells mediate early mouse fetal ovarian development but surface-derived Lgr5+ cells support primordial follicles

Ovarian murine somatic cells are essential to form first wave medullar follicles and second wave primordial follicles. Using single cell RNA sequencing we characterized the transcriptomes of both somatic and germline ovarian cells during fetal and early neonatal development. Wnt4-expressing somatic cells we term “escort-like cells (ELCs)” interact with incoming germ cells and early developing cysts of both sexes. In the medullar region, ELCs differentiate into the granulosa cells of fast-growing first wave follicles. In contrast, after E12.5, Lgr5+ pre-granulosa cells ingress from the ovarian surface epithelium and replace cortical escort-like cells. These surface-derived cells become the main population of granulosa cells supporting primordial follicles, and differ in transcription from ELC derivatives. Reflecting their different cellular origins, ablation of Lgr5+ cells at E16.5 using Lgr5-DTR-EGFP eliminates second wave follicles, but first wave follicles continue to develop normally and support fertility. Our findings provide striking evidence that somatic cell behavior supporting germline cyst development in mice and Drosophila has been evolutionarily conserved.
HLA-DRB1typing among Type I Diabetic Patients and their First Degree relatives in a Comparative Study

Background: The genetic susceptibility to IDDM maps to the MHC class II region, thus one approach to investigating the immunopathogenesis of diabetes is to study first degree relatives of affected individuals. Objectives: To detect the inherited relationship between (HLA-DRB1) allels and type one Diabetic mellitus. Methodology: A case-control study was performed on 90 persons, they divided into three group which are diabetic, siblings and control (30 persons in each group), who attended to Al Zahraa Teaching Hospital /Diabetic Center in Al Kut/Iraq between the period of April; 2012 till April; 2013.data was analyzed by using SPSS 16th version. Distribution of HLA-DRB1 loci among the study groups (type 1 Diabetic patients, Siblings and Control group) were performed using MR.SPOT ROBOTING system. Results: results showed that the frequencies of HLA-DRB1*3,*4 {25 (69.4%)} among Diabetic group were Significant (P value = 0.002), in compare to the corresponding frequencies among control group {11 (30.6%)}, in compare to the frequencies of other HLA-DRB1 loci in both Diabetic group and Control group { 15 (34.1%), 29 (65.9%)} respectively. Meanwhile results have showed that there were no Significant (P value = 0.116), in the frequencies of HLA-DRB1*3,*4 {25 (58.1%)} among Diabetic group in compare to the frequencies of HLA-DRB1*3,*4 {18 (41.9%)} among Siblings group, in compare to the frequencies of other HLA-DRB1 loci among Diabetic group and Sibling group {15 (40.5%), 22 (59.5%)} respectively, also results have showed that there were no Significant (P value = 0.104), in the frequencies of HLA-DRB1*3,*4 {18 (62.1%)} among Sibling group in compare to the frequencies of HLA-DRB1*3,*4 {11 (37.9%)} among Control group, in compare to the frequencies of other HLA-DRB1 loci among Sibling group and Control group {22 (43.1%), 29 (56.9%)} respectively. conclusion: In conclusion there were a genetic predisposition of diabetic Siblings for development of Diabetes since, both Diabetic group and Sibling group showing the highest frequencies of HLA-DRB1 *3,*4, in compare to Control group. Recommendation: larger sample group are required to include other allels