Miracle-dz/UniFAR-FTUs huggingface dataset:
Preparation of a green nanocomposite from Cinnamomum zeylanicum and its effect on some immunological parameters in rats with rheumatoid arthritis

The current study aimed to evaluate the anti-arthritic effects of a nanocomposite from Cinnamomum zeylanicum, and to further demonstrate its mechanism of action in RA induced RA by Complete Freund's Adjuvant (CFA). and it was diagnosed by atomic force microscopy (AFM) and infrared spectroscopy (FT-IR) revealed the emergence of new diffraction levels for nanocomposites, which clearly indicates the success of the loading process. X-ray evaluation clearly showed the severity of joint deformity according to the extent of osteoarthritis, joint spaces, soft tissue inflammation, subchondral erosion, and articular sclerosis. The immunological results indicated that the induction of rheumatoid arthritis (RF) in male G2 white rats led to a significant (P<0.05) increase in the level of IL-1β and IL-6 cytokines (186.89,109.52) pg/ml both compared with the control group. Negative (G1) (29.40,32.48) pg/ml. There was also a significant decrease (P<0.05) for the concentration level of IL-1β, IL-6 in the G7 group dosed with cinnamon nano compound loaded with MTX pg/ml (34.33, 48.62), respectively, the present results indicate that the stable nanoparticles with Ceylon Cinnamomum extract (Z.C./NPs) have potent anti-arthritic activity that is mediated by IL-6, IL-1β inhibition and cytokine resistance. Inflammatory.
Analysis of Associating Radiologic Parameters With Clinical Outcomes After Posterior C1–2 Fusion

Objective To evaluate which radiologic parameters affect clinical outcomes in patients underwent posterior C1–2 fusion for atlantoaxial dislocation. Methods From January 2014 to December 2017, among 98 patients underwent C1–2 posterior fusion, patients with previous cervical surgery or extending to subaxial spine or basilar invagination were excluded. Finally, 38 patients were included. O–C2, C1–2, C1–C7, C2–C7 cobb angle (CA), T1 slope, C1–7, C2–7 sagittal vertical axis (SVA), and posterior atlantodental interval (PADI) were measured at preoperative and postoperative 1 year. The difference between postoperative and preoperative values for each parameter was designated as Δvalue. Postoperative subaxial kyphosis (PSK) was defined to decrease ≥ 10° at subaxial spine. Visual analogue scale (VAS), Japanese Orthopedic Association (JOA) score, Neck Disability Index (NDI) were used to evaluate clinical outcomes. Results Mean age was 54.4 ± 15.9. Male to female was 14 to 24. Of radiologic parameters, C1–7 SVA and PADI were significantly changed from 26.4 ± 12.9 mm, 17.1 ± 3.3 mm to 22.6 ± 13.0 mm, 21.6 ± 3.4 mm. ΔC1–2 CA was correlated with ΔC1–7 CA and ΔC2–7 SVA. ΔPADI correlates with ΔO–C2 CA. VAS correlates with ΔC1–7 CA (p = 0.03). JOA score also correlates with ΔC2–7 SVA (p = 0.02). NDI was associated with ΔPADI (p < 0.01). The incidence of PSK was 23.7%, and not significant with clinical outcomes. Conclusion ΔC1–2 CA was correlated with ΔC1C7 CA, ΔC2–7 SVA. ΔC1–7 CA, ΔC2–7 SVA, and ΔPADI were the key radiologic parameters to influence clinical outcomes. Postoperative C1–2 angle should be carefully determined as a factor affecting clinical outcomes and cervical sagittal alignment.
Effect of Continuous Nursing Model Based on WeChat Public Health Education on Self-Management Level and Treatment Compliance of Stroke Patients

Background: To analyze the effect of continuous nursing model based on WeChat public health education on self-management level and treatment compliance of stroke patients. Methods: Overall, 98 stroke patients admitted to the Second Affiliated Hospital of Chongqing Medical University, ChongQing, 400000,China from Feb 2018 to Feb 2019 were enrolled as the research objects. They were randomly and equally divided into experimental group and control group. The control group received routine nursing management model while the experimental group received continuous nursing model based on WeChat public health education to compare the self-management level, treatment compliance, life quality and other indexes between the two groups. Results: The overall self-management level in the experimental group was significantly higher than that in the control group (P<0.05). The life quality scores in both groups after nursing intervention increased, and the scores in the experimental group after nursing intervention were significantly higher than those in the control group (P<0.001). The total treatment compliance rate in the experimental group was higher than that in the control group (P=0.001). After nursing intervention, the readmission rate and complication rate in the experimental group were significantly lower than those in the control group (P<0.05). Conclusion: The implementation of continuous nursing model based on WeChat public health education for stroke patients can significantly enhance the self-management level, improve the cognitive level on stroke related-health knowledge, improve treatment compliance of patients in the nursing process, promote their physical and mental health, improve the life quality and effectively reduce the complication rate and readmission rate.
Mechanistic Evaluation of Antimicrobial Lipid Interactions with Tethered Lipid Bilayers by Electrochemical Impedance Spectroscopy

There is extensive interest in developing real-time biosensing strategies to characterize the membrane-disruptive properties of antimicrobial lipids and surfactants. Currently used biosensing strategies mainly focus on tracking membrane morphological changes such as budding and tubule formation, while there is an outstanding need to develop a label-free biosensing strategy to directly evaluate the molecular-level mechanistic details by which antimicrobial lipids and surfactants disrupt lipid membranes. Herein, using electrochemical impedance spectroscopy (EIS), we conducted label-free biosensing measurements to track the real-time interactions between three representative compounds—glycerol monolaurate (GML), lauric acid (LA), and sodium dodecyl sulfate (SDS)—and a tethered bilayer lipid membrane (tBLM) platform. The EIS measurements verified that all three compounds are mainly active above their respective critical micelle concentration (CMC) values, while also revealing that GML induces irreversible membrane damage whereas the membrane-disruptive effects of LA are largely reversible. In addition, SDS micelles caused membrane solubilization, while SDS monomers still caused membrane defect formation, shedding light on how antimicrobial lipids and surfactants can be active in, not only micellar form, but also as monomers in some cases. These findings expand our mechanistic knowledge of how antimicrobial lipids and surfactants disrupt lipid membranes and demonstrate the analytical merits of utilizing the EIS sensing approach to comparatively evaluate membrane-disruptive antimicrobial compounds.
Left Heart Failure Caused by Capacity Overload in Peritoneal Dialysis Patients

Background This study sets out to investigate the incidence of acute left ventricular failure in peritoneal dialysis patients with different volume loads and to analyze the related risk factors for LVF in these patients. Methods This study involved patients who received peritoneal dialysis in our hospital between September 2018 and January 2021. The demographic data and biochemical indicators of the patients were collected. The bioimpedance analysis method was used to determine the volume overload [overhydration (OH)] level of patients, and cardiac color Doppler ultrasound was used to detect changes in their cardiac structure. According to the LVF diagnostic criteria of symptoms and laboratory tests, the patients were divided into the LVF and non-LVF groups and then divided according to their OH level into the normal volume (OH ≤1.1 L) and volume overload (OH >1.1 L) groups. The incidence of LVF in was analyzed in patients with different volume loads, and logistic regression was used to identify the risk factors for LVF. Results Among the 226 peritoneal dialysis patients enrolled in this study, 125 patients (55.3%) had LVF. The normal volume group (n = 68, 30.1%) included 22 patients (32.4%) with LVF, and the volume overload group (n = 158, 69.9%) included 84 patients (53.2%) with LVF. In the volume overload group, 74 patients (46.8%) had subclinical volume overload, including 35 patients (47.3%) with LVF, and 84 patients (53.2%) had clinical volume overload, including 65 patients (77.4%) LVF. Multivariate logistic regression analysis revealed a high OH level (OR = 1.862, 95% CI: 1.353–2.668, P < 0.001) and low hemoglobin level (OR = 0.845, 95% CI: 0.721–0.980, P = 0.008) to be independent risk factors for LVF. Conclusions LVF has a high incidence in peritoneal dialysis patients, especially those with volume overload. A high OH level and low hemoglobin level are independent risk factors for LVF.
Voluntary Transparency in Spanish University Libraries

The research reported here aimed to ascertain the degree of transparency exhibited by Spanish public university libraries based on their active public disclosure practice. Transparency was measured by applying the TransPa_BA tool to the transparency-related information published by the country’s 50 public university libraries on their websites. The tool addresses 21 indicators grouped under eight areas, used in this study to measure university libraries’ public disclosure performance. The data collected were scored pursuant to the provisions of Spanish Act 19/2013 of 9 December on Transparency, Access to Public Information and Good Governance as adapted to university libraries, as well as in terms of other factors scantly developed in or omitted from the Act. The indicators and their respective parameters (content, form, accessibility, reusability, dating and updating or validity) constitute guidelines enabling libraries to enhance transparency and accountability by reporting their activities and practice in key areas to society in general and their stakeholders in particular. The objective is to help such institutions operate more transparently, for the information afforded by the indicators is deemed relevant to their activity while also monitoring their performance. The findings show that university libraries, which have become more transparent over time, are more transparent than other information units (national public libraries and historic and university archives). Some were nonetheless found to have room for improvement. On the grounds of their scores, these libraries can be classified under three headings: transparent, translucent or opaque. The parameters where good practices were most frequently identified included service usage rules and regulations, user charters and the annual report.
Mechanisms of Mitochondrial Malfunction in Alzheimer's Disease: New Therapeutic Hope

Mitochondria play a critical role in neuron viability or death as it regulates energy metabolism and cell death pathways. They are essential for cellular energy metabolism, reactive oxygen species production, apoptosis, Ca++ homeostasis, aging, and regeneration. Mitophagy and mitochondrial dynamics are thus essential processes in the quality control of mitochondria. Improvements in several fundamental features of mitochondrial biology in susceptible neurons of AD brains and the putative underlying mechanisms of such changes have made significant progress. AD's etiology has been reported by mitochondrial malfunction and oxidative damage. According to several recent articles, a continual fusion and fission balance of mitochondria is vital in their normal function maintenance. As a result, the shape and function of mitochondria are inextricably linked. This study examines evidence suggesting that mitochondrial dysfunction plays a significant early impact on AD pathology. Furthermore, the dynamics and roles of mitochondria are discussed with the link between mitochondrial malfunction and autophagy in AD has also been explored. In addition, recent research on mitochondrial dynamics and mitophagy in AD is also discussed in this review. It also goes into how these flaws affect mitochondrial quality control. Furthermore, advanced therapy techniques and lifestyle adjustments that lead to improved management of the dynamics have been demonstrated, hence improving the conditions that contribute to mitochondrial dysfunction in AD.
Factors Associated with Infant Mortality Due to Congenital Anomalies: A Population-Based Case-Control Study

Background: Congenital anomalies are one of the major public health problems and one of the leading cause of infant mortality and morbidity. We aimed to investigate some factors associated with infant mortality due to congenital anomalies in several provinces of Iran. Methods: This case-control study was conducted on 2199 women referring health centers of nine provinces of Iran 2015-2018. Cases were defined as mothers with infant death due to congenital anomalies, and control group comprised of mothers with live birth or infant deaths due to other causes (n=1986). The descriptive data were expressed as percentage and frequency. Factors associated with infant death due to congenital anomalies were evaluated and analyzed at 95% confidence level by logistic regression analysis. Results: The multiple logistic regression analysis reveal that history of cesarean delivery [OR:2.13 ;95%CI (1.58–2.87)], maternal age [OR:1.94 ;95%CI (1.31–2.86)])], area of living [OR: 1.69;95%CI (1.22–2.33)], maternal smoking during pregnancy [OR: 1.41; 95%CI (1.02–1.95)], consanguineous marriage [OR:1.53;95%CI (1.12–2.08)], also low birth weight [OR: 3.09; 95%CI (2.23–4.30)] were significantly associated with infant death due to congenital anomalies. Conclusion: Identification of factors associated with congenital anomalies has been shown to reduce treatment costs and medical complications of neonates. Therefore, genetic counseling and educational programs for high-risk women, and prenatal screening are essential to identify and prevent factors contributing to congenital abnormalities.
Web-Based Educational Resources for Indian Medical Graduates

Background: Nowadays, students have a vast knowledge of multimedia. Social media is an online platform that allows community building through collaboration. Objectives: The present study aimed to understand the use of web-based resources for educational purposes by medical students. Methods: This cross-sectional survey was conducted for three months on the students, interns, and residents of a tertiary care hospital and Government Medical College, Surat, India. Informed consent was taken from the participants, and a pre-approved questionnaire was delivered to all of them for data collection. The data were entered using the Google spreadsheet and were expressed using descriptive statistics. Results: Out of the study population consisting of 900 individuals, 646 filled the questionnaires and were finally evaluated. Out of 646, 430 individuals were medical students, 335 were female, and 303 were male. The majority (91.9%) of the responders were exposed to computer education in their schools. We found that 549 (86.4%) people were aware of the free internet access provided to them in the college library. Almost 97% (617) of the responders had mobile phones with internet access, and 80.1% connected to the internet more than once a day. The results of this study showed that 94.4% of the participants accepted that they used internet-based media to enhance their academic knowledge, while 66.5% agreed that internet resources are giving much unreliable information. Moreover, 55.8% of the responders were associated with the academic e-learning groups. Only 55 (8.7%) respondents had received formal training for online literature search. Conclusions: The emergence of various social media applications and web-based resources provides us with more collaborative approaches to medical education. However, implementing new technologies also creates new challenges and opportunities for students and faculties. Training concerning internet search and web-based resources is important to enhance their e-learning skills.
Do Hypertensive Disorders of Pregnancy and Abnormal Placentation Mediate the Association between Advanced Maternal Age and Adverse Perinatal Outcomes?

Background: A tertiary-hospital-based retrospective study (2011–2019) was conducted to determine the mediating role of hypertensive disorders of pregnancy and abnormal placentations between advanced maternal age and adverse neonatal outcomes. Methods: Data from a tertiary-hospital-based retrospective study (n= 23051) was used and conducted regression-based mediation analysis to assess the mediating role of hypertensive disorders of pregnancy and abnormal placentation between the advanced maternal age and adverse neonatal outcomes. Results: After adjusting for confounding factors, the indirect effect of advanced maternal age on preterm births, perinatal mortality, and low birth weight mediated by hypertensive disorders of pregnancy was [aOR 4.95 (95% CI: 4.05, 5.85)], [aOR 2.82 (95% CI: 1.78, 3.86)], and [aOR 5.90 (95% CI: 4.93, 6.87)], respectively. The indirect effect of advanced maternal age on preterm births and low birth weight mediated by abnormal placentation was [aOR 6.83 (95% CI: 5.70, 7.97)] and [aOR 4.18 (95% CI: 3.26, 5.11)]. About, 23%, 37%, and 17% of the effect of advanced maternal age on preterm births, perinatal mortality, and low birth weight was mediated by hypertensive disorders of pregnancy, respectively. Furthermore, abnormal placentation mediates the association between advanced maternal age and preterm births by 18% and low birth weight by 23%. Conclusion: Hypertensive disorders of pregnancy and abnormal placentation partially mediate the association between advanced maternal age and adverse neonatal outcomes.
Methylene blue-mediated photodynamic therapy in the treatment of oral microbiota. A Systematic Review

Objective: The objective of the present review was to relate the scientific production presented in the last 5 years on the effect of photodynamic therapy using the methylene blue photosensitizer on the microorganisms present in the oral biofilm. Methods: systematic review looking for research in English of primary studies such as randomized clinical trials and without randomization, individual case-control, and qualitative descriptive studies, using the PubMed/MEDLINE and Scopus databases as references, from 2017 to 2021. Results: 15 articles were analyzed, being 67% national publications and 33% international studies. Considering the samples described in the studies, 73% were in vitro, 7% were in vivo and 20% were clinical samples. As for the light source, 66% used laser, 20% used LED and 14% the association of laser and LED devices. The power density used ranged from 0.0026 W/cm2 to 1415 W/cm2. The energy density ranged from 3 J/cm2 to 640 J/cm2. The power ranged from 10 mW to 110 mW. The irradiation time ranged from 24 to 294 seconds. In most publications, 87% used the wavelength of 660 nm. As for the photosensitizer, the most used concentration, in 33% of the studies, was 0.01%, with the pre-irradiation time most used being 300 seconds in 40% of the studies. Conclusion: Photodynamic Methylene Blue Therapy is being accepted as effective in therapies of various oral curative conditions and has been shown to be a useful and effective therapy, as well as a complementary approach to control the development/growth of oral biofilm in clinical situations.
Perception of Directionality in Translation Among Students

The present study, in the form of a questionnaire, aims to analyse students’ subjective perception of directionality in translation. Additionally, it places a particular emphasis on the aspects which are perceived as difficult in each direction. Although for most students, L2 translation is more cognitively demanding, and they prefer to translate into L1, such preferences may change as the result of the amount of translation training. Students with a longer span in translation training frequently encounter more problems in L1 translation and may not have any preferred direction of translation. Nevertheless, the importance of practicing translating into L2 has been emphasized in many aspects, like expanding L2 competence or translation market demand; additionally, it is also a preferred language of translation for some students. Vocabulary and terminology have been described as the most problematic in both directions of translation. Other aspects which pose many problems and require some training are both L1 and L2 grammar as well as punctuation.
PERBANYAKAN ANGGREK HITAM (Coeloegyne pandurata)DENGAN MEDIA ORGANIK DAN VACIN WENT SECARA IN VITRO

Flora diversity in Indonesia is unrivaled and famous than other countries especially orchids. Currently the population of black orchid (Coeloegyne pandurata)had decreased because demand of black orchids is increase but this is a problem that black orchid will existence in their habitat. These problems can be overcome with orchid propagation through in vitro culture. The study was conducted using a completely randomized design (CRD) with one factor which media with 20 replications. The aim of this study is to obtain information as preliminary data on the response time growthof black orchid seeds and compare Vacin and Went (VW) medium with organic medium. Variables studied in this research is a time to grow, number of explants, number of leaves and number of roots. The results of this research that respose of VW medium and organic medium can be used as a propagation medium for black orchid in tissue culture 5 week after initiation/germination (week-5). Media VW has complete nutrients than organic medium.The result showed that the average number of explants (week-5) on mediumVW is 235.55 explants and medium organic is 191 explants.The result at week – 16 showed that average number of medium VW is 308.85 explants and mediais 256.65 explants. Observations average number of leaves showed that on mediumVW is 2.75 leaves and medium organic 2.05 leaves. Key Word : Black Orchid, Tisuue Culture, VW Medium , Organic medium dan In Vitro
Can Lung Imaging Scores and Clinical Variables Predict Severe Course and Fatal Outcome in COVID-19 Pneumonia Patients? A Single-Center Observational Study

COVID-19 prediction models mostly consist of combined clinical features, laboratory parameters, and, less often, chest X-ray (CXR) findings. Our main goal was to propose a prediction model involving imaging methods, specifically ultrasound. This was a single-center, retrospective cohort observational study of patients admitted to the University Hospital Split from November 2020 to May 2021. Imaging protocols were based on the assessment of 14 lung zones for both lung ultrasound (LUS) and computed tomography (CT), correlated to a CXR score assessing 6 lung zones. Prediction models for the necessity of mechanical ventilation (MV) or a lethal outcome were developed by combining imaging, biometric, and biochemical parameters. A total of 255 patients with COVID-19 pneumonia were included in the study. Four independent predictors were added to the regression model for the necessity of MV: LUS score, day of the illness, leukocyte count, and cardiovascular disease (χ2 = 29.16, p < 0.001). The model accurately classified 89.9% of cases. For the lethal outcome, only two independent predictors contributed to the regression model: LUS score and patient’s age (χ2 = 48.56, p < 0.001, 93.2% correctly classified). The predictive model identified four key parameters at patient admission which could predict an adverse outcome.