Miracle-dz/UniFAR-FTUs huggingface dataset:
THE RATE AND CHARACTERS OF MASKED ARTERIAL HYPERTENSION AND MASKED INEFFECTIVENESS OF HYPERTENSION TREATMENT IN INDUSTRIAL WORKERS ACCORDING TO THE PREVENTIVE EXAMINATION

Aim. To study the rate and characters of masked arterial hypertension (HT) and masked ineffectiveness of HT treatment in industrial workers within annual preventive examination. Material and methods. Workers (n=185) with normal office blood pressure (BP) <140 and <90 mm Hg were enrolled into cross-cohort study of industrial workers of large enterprise engaged in activity with harmful and/or dangerous conditions (n=477; mean age 53.2±5.5 years). Standard survey, anthropometry, ambulatory BP monitoring (ABPM), blood chemistry, electrocardiography, and echocardiography were performed. Criteria of masked HT and masked HT in treated subjects were the level of office BP <140 and <90 mm Hg in combination with mean BP during the operational period ≥135 and/or ≥85 mmHg. Patient characters significantly associated with this ratio of office BP and BP during the operational period were considered as features of isolated increase in ambulatory BP level. Results. The rate of masked HT among workers with normal office BP was 10.8%, and masked HT among treated subjects was 34.6%. Workers with masked HT, in contrast to the normotensive workers according to the office BP and ABPM measurements, had a higher left ventricular mass index (in males 129.0±21.2 vs. 109.5±28.8 g/m2, respectively, in women 105.2±43.2 vs. 82.4±25.3 g/m2, respectively, p<0.05), and higher body weight (85.4±13.3 vs. 81.3±10.1 kg, respectively; p=0.05). Treated subjects with masked HT, unlike workers with effective antihypertensive therapy had a higher body weight (89.4±16.1 vs. 85.4±15.8 kg, respectively, p<0.05), higher levels of triglycerides (1.56±0.95 vs. 1.23±0.55 mmol/l, respectively, p<0.01) and uric acid (388.5±89.5 vs. 357.2±84.5 mmol/l, respectively, p<0.05), more prominent left ventricular hypertrophy, lower incidence of ischemic heart disease, but higher number of persons taking ACE inhibitors. Occupation and work features were not characters of the masked HT and masked ineffectiveness of HT treatment. Conclusion. Masked HT and masked HT in treated subjects (masked ineffectiveness of HT treatment) can occur in almost a half of industrial workers with normal office BP. Ambulatory BP measurement methods, especially ABPM, as well as standard risk factors detection are necessary for early revealing of HT phenotypes during preventive examination.
Exercise for preventing falls in older people living in the community: an abridged Cochrane systematic review

Objectives To assess the effects of exercise interventions for preventing falls in older people living in the community. Selection criteria We included randomised controlled trials evaluating the effects of any form of exercise as a single intervention on falls in people aged 60+years living in the community. Results Exercise reduces the rate of falls by 23% (rate ratio (RaR) 0.77, 95% CI 0.71 to 0.83; 12 981 participants, 59 studies; high-certainty evidence). Subgroup analyses showed no evidence of a difference in effect on falls on the basis of risk of falling as a trial inclusion criterion, participant age 75 years+ or group versus individual exercise but revealed a larger effect of exercise in trials where interventions were delivered by a health professional (usually a physiotherapist). Different forms of exercise had different impacts on falls. Compared with control, balance and functional exercises reduce the rate of falls by 24% (RaR 0.76, 95% CI 0.70 to 0.81; 7920 participants, 39 studies; high-certainty evidence). Multiple types of exercise (commonly balance and functional exercises plus resistance exercises) probably reduce the rate of falls by 34% (RaR 0.66, 95% CI 0.50 to 0.88; 1374 participants, 11 studies; moderate-certainty evidence). Tai Chi may reduce the rate of falls by 19% (RaR 0.81, 95% CI 0.67 to 0.99; 2655 participants, 7 studies; low-certainty evidence). We are uncertain of the effects of programmes that primarily involve resistance training, dance or walking. Conclusions and implications Given the certainty of evidence, effective programmes should now be implemented.
Characterization of An Extensive Interface on Vitronectin for Binding to PAI-1: Adoption of Structure in an Intrinsically Disordered Region.

Small-angle neutron scattering (SANS) measurements were pursued to study human vitronectin, a protein found in tissues and the circulation that regulates cell adhesion/migration and proteolytic cascades that govern hemostasis and pericellular proteolysis. Many of these functions occur via interactions with its binding partner, plasminogen activator inhibitor-1 (PAI-1), the chief inhibitor of proteases that lyse and activate plasminogen. We focused on a region of vitronectin that remains uncharacterized from previous x-ray scattering, NMR and computational modeling approaches and which we propose is involved in binding to PAI-1. This region, which bridges the N-terminal somatomedin B (SMB) domain with a large central beta-propeller domain of vitronectin, appears unstructured and has characteristics of an intrinsically disordered domain (IDD). The effect of osmolytes was evaluated using circular dichroism and SANS to explore the potential of the IDD to undergo a disorder-to-order transition. The results suggest that the IDD favors a more ordered structure under osmotic pressure; SANS shows a smaller radius of gyration (Rg) and a more compact fold of the IDD upon addition of osmolytes. To test whether PAI-1 binding is also coupled to folding within the IDD structure, a set of SANS experiments with contrast variation were performed on the complex of PAI-1 with a vitronectin fragment corresponding to the N-terminal 130 amino acids (denoted SMB-IDD because it contains the SMB domain and IDD in linear sequence). Analysis of the SANS data using the Ensemble Optimization Method confirms that the SMB-IDD adopts a more compact configuration when bound to PAI-1. Calculated structures for the PAI-1:SMB-IDD complex suggest that the IDD provides an interaction surface outside of the primary PAI-1-binding site located within the SMB domain; this binding is proposed to lead to the assembly of higher-order structures of vitronectin and PAI-1 commonly found in tissues.
Quantitative Protein Expression in the Human Retinal Pigment Epithelium: Comparison Between Apical and Basolateral Plasma Membranes With Emphasis on Transporters.

Purpose Retinal pigment epithelium (RPE) limits the xenobiotic entry from the systemic blood stream to the eye. RPE surface transporters can be important in ocular drug distribution, but it has been unclear whether they are expressed on the apical, basal, or both cellular surfaces. In this paper, we provide quantitative comparison of apical and basolateral RPE surface proteomes. Methods We separated the apical and basolateral membranes of differentiated human fetal RPE (hfRPE) cells by combining apical membrane peeling and sucrose density gradient centrifugation. The membrane fractions were analyzed with quantitative targeted absolute proteomics (QTAP) and sequential window acquisition of all theoretical fragment ion spectra mass spectrometry (SWATH-MS) to reveal the membrane protein localization on the RPE cell surfaces. We quantitated 15 transporters in unfractionated RPE cells and scaled their expression to tissue level. Results Several proteins involved in visual cycle, cell adhesion, and ion and nutrient transport were expressed on the hfRPE plasma membranes. Most drug transporters showed similar abundance on both RPE surfaces, whereas large neutral amino acids transporter 1 (LAT1), p-glycoprotein (P-gp), and monocarboxylate transporter 1 (MCT1) showed modest apical enrichment. Many solute carriers (SLC) that are potential prodrug targets were present on both cellular surfaces, whereas putative sodium-coupled neutral amino acid transporter 7 (SNAT7) and riboflavin transporter (RFT3) were enriched on the basolateral and sodium- and chloride-dependent neutral and basic amino acid transporter (ATB0+) on the apical membrane. Conclusions Comprehensive quantitative information of the RPE surface proteomes was reported for the first time. The scientific community can use the data to further increase understanding of the RPE functions. In addition, we provide insights for transporter protein localization in the human RPE and the significance for ocular pharmacokinetics.
Probing the effect of ortho-cycloalkyl ring size on activity and thermostability in cycloheptyl-fused N,N,N-iron ethylene polymerization catalysts.

The syntheses of six bis(imino)-5,6,7,8-tetrahydrocycloheptapyridine-iron(ii) chloride complexes, [2-{(Ar)NCMe}-9-{N(Ar)}C10H10N]FeCl2 (Ar = 2-(C5H9)-6-MeC6H3 Fe1, 2-(C6H11)-6-MeC6H3 Fe2, 2-(C8H15)-6-MeC6H3 Fe3, 2-(C5H9)-4,6-Me2C6H2 Fe4, 2-(C6H11)-4,6-Me2C6H2 Fe5, 2-(C8H15)-4,6-Me2C6H3 Fe6), are reported in which the ring size of the ortho-cycloalkyl group has been varied as has the type of para-substituent. The molecular structures of Fe3 and Fe6 reveal square pyramidal geometries at iron while the ortho-cyclooctyl rings adopt boat-chair conformations. On treatment with either methylaluminoxane (MAO) or modified methylaluminoxane (MMAO), all six complexes showed optimal activities at 80 °C [up to 1.9 × 107 g of PE per mol Fe per h for Fe5/MMAO] for ethylene polymerization forming linear polyethylene (Tm's > 126 °C). Notably, the catalytic activities showed a marked correlation with the ring size of the ortho-cycloalkyl substituent: cyclohexyl (Fe2 and Fe5) > cyclooctyl (Fe3 and Fe6) > cyclopentyl (Fe1 and Fe4) for either para-substituent, H or Me. Furthermore, this family of iron catalysts exhibited remarkable thermostability by remaining highly active even at temperatures as high as 100 °C (1.1 × 107 g of PE per mol Fe per h); the wide variation in polymer molecular weights (Mw: 2.4-166 kg mol-1), influenced through choice of precatalyst and co-catalyst as well as by temperature and pressure, further highlights the versatility of these catalysts.
A New Theory of Gender Dysphoria Incorporating the Distress, Social Behavioral, and Body-Ownership Networks

When postmortem studies related to transgender individuals were first published, little was known about the function of the various identified nuclei. Now, over 2 decades later, significant progress has been made associating function with specific brain regions, as well as in identifying networks associated with groups of behaviors. However, much of this progress has not been integrated into the general conceptualization of gender dysphoria in humans. Abstract When postmortem studies related to transgender individuals were first published, little was known about the function of the various identified nuclei. Now, over 2 decades later, significant progress has been made associating function with specific brain regions, as well as in identifying networks associated with groups of behaviors. However, much of this progress has not been integrated into the general conceptualization of gender dysphoria in humans. I hypothesize that in individuals with gender dysphoria, the aspects of chronic distress, gender atypical behavior, and incongruence between perception of gender identity and external primary sex characteristics are all directly related to functional differences in associated brain networks. I evaluated previously published neuroscience data related to these aspects and the associated functional networks, along with other relevant information. I find that the brain networks that give individuals their ownership of body parts, that influence gender typical behavior, and that are involved in chronic distress are different in individuals with and without gender dysphoria, leading to a new theory—that gender dysphoria is a sensory perception condition, an alteration in the sense of gender influenced by the reflexive behavioral responses associated with each of these networks. This theory builds upon previous work that supports the relevance of the body-ownership network and that questions the relevance of cerebral sexual dimorphism in regard to gender dysphoria. However, my theory uses a hierarchical executive function model to incorporate multiple reflexive factors (body ownership, gender typical/atypical behavior, and chronic distress) with the cognitive, reflective process of gender identity.
Tubal cancer in a young woman camouflaged as bilateral salpingitis

Introduction: Primary fallopian tube carcinoma (PFTC) is extremely uncommon, accounting for between 0.1–1.8% of all gynecological cancers diagnosed. Due to nonspecific symptoms, the diagnosis is often mistaken for an ovarian carcinoma or a tube-ovarian mass. Objective: To report an interesting case of tubal cancer diagnosed in à nullipare patient. Materials and Methods: We report about a 26-year old premenopausal patient presented with a 15-day history of mesocycle vaginal bleeding and lower abdominal pain, with multiple abdominopelvic masses, detected through pelvic ultrasound. Results: Exploratory laparotomy was performed, and one of the tumors was diagnosed as a primary fallopian tube carcinoma (PFTC), as well as bilateral salpingitis’ formations. The patient underwent complete cytoreduction. Pathology confirmed a high-grade serous carcinoma of the left salpinx with a FIGO stage considered as 1A2, and the patient received adjuvant chemotherapy. Ten months after initial surgery, the patient is alive and in good condition. Conclusion: Tubal cancer is extremely rare in young patients, however it should be considered in the differential diagnosis of adnexal tumors.
The three-year monitoring of 18 elements in five edible mushroom species collected from an old orchard

Abstract The content of Al, As, Be, Cd, Ca, Cr, Co, Cu, Fe, Pb, Li, Mg, Mn, Ni, Rb, Se, Sr, and Zn in fruiting bodies of edible mushrooms Calocybe gambosa, Entoloma clypeatum, Entoloma saepium, Xerocomellus chrysenteron, and Amanita rubescens growing in an orchard planted with fruit trees and situated close to a high-grown forest was studied during years 2016–2018. A. rubescens showed the highest potential of the element accumulation with bioconcentration factors of 48.5, 16.2, 7.80, 6.53, 1.75, and 1.68 obtained for Rb, Cd, Cu, Zn, Sr, and Mg, respectively. Both Entoloma species accumulated the elements similarly with bioconcentration factors >1.0 obtained for Rb, Cu, Cd, and Mg. Bioconcentration factors <0.05 were obtained for Al, Cr, Fe, and Pb in all studied species. The contents of beryllium (<0.1 mg/kg dry matter) were always the lowest among the studied elements. The contents of some elements of studied mushroom species significantly fluctuated over the years. Despite the fact that some studied elements (As, Be, Cd, Pb, Ni) are considerably toxic for humans, the pronounced effect on health is not expected if the studied mushroom species are consumed occasionally and do not represent the main component of the diet.
Neurophysiological correlates of force control improvement induced by sinusoidal vibrotactile stimulation

Objective. An optimal level of vibrotactile stimulation has been shown to improve sensorimotor control in healthy and diseased individuals. However, the underlying neurophysiological mechanisms behind the enhanced motor performance caused by vibrotactile stimulation are yet to be fully understood. Therefore, here we aim to evaluate the effect of a cutaneous vibration on the firing behavior of motor units in a condition of improved force steadiness. Approach. Participants performed a visuomotor task, which consisted of low-intensity isometric contractions of the first dorsal interosseous (FDI) muscle, while sinusoidal (175 Hz) vibrotactile stimuli with different intensities were applied to the index finger. High-density surface electromyogram was recorded from the FDI muscle, and a decomposition algorithm was used to extract the motor unit spike trains. Additionally, computer simulations were performed using a multiscale neuromuscular model to provide a potential explanation for the experimental findings. Main results. Experimental outcomes showed that an optimal level of vibration significantly improved force steadiness (estimated as the coefficient of variation of force). The decreased force variability was accompanied by a reduction in the variability of the smoothed cumulative spike train (as an estimation of the neural drive to the muscle), and the proportion of common inputs to the FDI motor nucleus. However, the interspike interval variability did not change significantly with the vibration. A mathematical approach, together with computer simulation results suggested that vibrotactile stimulation would reduce the variance of the common synaptic input to the motor neuron pool, thereby decreasing the low frequency fluctuations of the neural drive to the muscle and force steadiness. Significance. Our results demonstrate that the decreased variability in common input accounts for the enhancement in force control induced by vibrotactile stimulation.
Trend in childhood obesity reflects socioeconomic status in Argentina

Abstract Background: Surveillance of childhood obesity is essential to guide preventive policies and interventions. Aim: To analyse trends in overweight and obesity by socioeconomic status (SES) in Argentinian schoolchildren during the last decade. Subjects and methods: Two cross-sectional studies in schoolchildren aged 6–12 years were compared. The first study was conducted in 2005/07 (n = 1418) and the second one in 2015/16 (n = 1366). Overweight and obesity were estimated by the International Obesity Task Force (IOTF) cut-offs. The type of school (public/private) and parental education level were used as measures of SES. Data were analysed by linear and logistic regression with survey year, type of school, parental education level, and sex as independent variables. Results: From 2005 to 2016 overweight and obesity increased by 7.3% and 5.0%, respectively. The change was significantly higher in boys (9.6% and 8.3%) and girls (9.6% and 5.4%) from public schools, and in children whose fathers had low (10% and 8.3%) and middle (9.0% and 5.5%) education levels. No significant changes were found in children attending private school or those whose fathers had a higher education level. Conclusions: Obesity is still increasing in this population. SES disparities are strongly associated with this trend, with stabilisation in children from high SES.
The influence of the global electric power system on terrestrial biodiversity

Significance Understanding the relationship between the global electric power sector and biodiversity is central to identifying sustainable pathways to decarbonization. This study examines the relationship between the global electric power sector and threats to biodiversity. The biodiversity footprint of the electric power sector is primarily within the territory where demand for power resides, although substantial regional differences exist. The relationship between supply technologies and threats to biodiversity indicates that a shift to some nonfossil sources could reduce pressures on biodiversity, although there is uncertainty in how threats will scale given current deployment levels of nonfossil sources. The strong territorial link between electric power demand and biodiversity threat provides clear routes for governments to effectively manage biodiversity impacts of electric power transitions. Given its total contribution to greenhouse gas emissions, the global electric power sector will be required to undergo a fundamental transformation over the next decades to limit anthropogenic climate change to below 2 °C. Implications for biodiversity of projected structural changes in the global electric power sector are rarely considered beyond those explicitly linked to climate change. This study uses a spatially explicit consumption-based accounting framework to examine the impact of demand for electric power on terrestrial vertebrate biodiversity globally. We demonstrate that the biodiversity footprint of the electric power sector is primarily within the territory where final demand for electric power resides, although there are substantial regional differences, with Europe displacing its biodiversity threat along international supply chains. The relationship between size of individual components of the electric power sector and threat to biodiversity indicates that a shift to nonfossil sources, such as solar and wind, could reduce pressures on biodiversity both within the territory where demand for power resides and along international supply chains. However, given the current levels of deployment of nonfossil sources of power, there is considerable uncertainty as to how the impacts of structural changes in the global electric power system will scale. Given the strong territorial link between demand and associated biodiversity impacts, development of strong national governance around the electric power sector represents a clear route to mitigate threats to biodiversity associated with efforts to decarbonize society over the coming century.
Discordant Chronic Conditions and Depressive Symptoms: Longitudinal Associations Among Middle-Aged and Older Couples.

OBJECTIVES Individuals often manage chronic conditions in middle and later life that may diminish well-being. Little is known, however, about discordant conditions (i.e., two or more conditions with competing self-management requirements) among older couples and their links to depressive symptoms. We considered discordant conditions at both the individual level and the couple level (i.e., between spouses), along with their long-term implications for depressive symptoms. METHODS The U.S. sample included 1,116 middle-aged and older couples drawn from five waves (2006-2014) of the Health and Retirement Study. Longitudinal actor-partner interdependence models evaluated whether individual-level and couple-level discordant chronic health conditions were concurrently linked to depressive symptoms, and whether these associations became stronger over time. Models controlled for age, minority status, education, prior wave depressive symptoms, and each partner's baseline report of negative marital quality and number of chronic conditions in each wave. RESULTS Wives and husbands reported significantly greater depressive symptoms when they had individual-level discordant conditions about 2 years after baseline, and these links intensified over time. Beyond this association, husbands had significantly greater depressive symptoms when there were couple-level discordant conditions. DISCUSSION Individual-level and couple-level discordant conditions may have lasting implications for depressive symptoms during midlife and older adulthood.