Miracle-dz/UniFAR-FTUs huggingface dataset:
My Diabetes Coach, a Mobile App–Based Interactive Conversational Agent to Support Type 2 Diabetes Self-Management: Randomized Effectiveness-Implementation Trial

Background Delivering self-management support to people with type 2 diabetes mellitus is essential to reduce the health system burden and to empower people with the skills, knowledge, and confidence needed to take an active role in managing their own health. Objective This study aims to evaluate the adoption, use, and effectiveness of the My Diabetes Coach (MDC) program, an app-based interactive embodied conversational agent, Laura, designed to support diabetes self-management in the home setting over 12 months. Methods This randomized controlled trial evaluated both the implementation and effectiveness of the MDC program. Adults with type 2 diabetes in Australia were recruited and randomized to the intervention arm (MDC) or the control arm (usual care). Program use was tracked over 12 months. Coprimary outcomes included changes in glycated hemoglobin (HbA1c) and health-related quality of life (HRQoL). Data were assessed at baseline and at 6 and 12 months, and analyzed using linear mixed-effects regression models. Results A total of 187 adults with type 2 diabetes (mean 57 years, SD 10 years; 41.7% women) were recruited and randomly allocated to the intervention (n=93) and control (n=94) arms. MDC program users (92/93 participants) completed 1942 chats with Laura, averaging 243 min (SD 212) per person over 12 months. Compared with baseline, the mean estimated HbA1c decreased in both arms at 12 months (intervention: 0.33% and control: 0.20%), but the net differences between the two arms in change of HbA1c (−0.04%, 95% CI −0.45 to 0.36; P=.83) was not statistically significant. At 12 months, HRQoL utility scores improved in the intervention arm, compared with the control arm (between-arm difference: 0.04, 95% CI 0.00 to 0.07; P=.04). Conclusions The MDC program was successfully adopted and used by individuals with type 2 diabetes and significantly improved the users’ HRQoL. These findings suggest the potential for wider implementation of technology-enabled conversation-based programs for supporting diabetes self-management. Future studies should focus on strategies to maintain program usage and HbA1c improvement. Trial Registration Australia New Zealand Clinical Trials Registry (ACTRN) 12614001229662; https://anzctr.org. au/Trial/Registration/TrialReview.aspx? ACTRN=12614001229662
Improvements in Direct Current Stator Winding Insulation Testing

Direct Current (DC) high voltage testing is frequently used to assess the condition of stator windings. The list of the reasons why DC tests may be preferred over alternating 50 Hz or 60 Hz voltage tests is long: smaller size of the test equipment, fewer partial discharges, less risk of damage in the case of very poor insulation quality. Different direct current test methods are possible such as DC HIPOT, polarization index test, ramped voltage test, uniform time and graded time voltage step test, insulation profiling, etc. Since the traditional DC hi-pot test is not a diagnostic test (the result of the test is either PASS or FAIL), an improved method of DC testing using ramped direct high voltage was introduced by Bruce McHenry in 1964 [6] and this paper describes the differences between the two ramped direct-high voltage methods proposed in IEEE 95.
Marketing Mix Study using Social Media in Hospital

: The hospitals industry with government policy make hospital at the moment has very tight competition, in private hospitals, need a good marketing strategy to maintain its existence also the new era of Healthcare National Services (Jaminan Kesehatan Nasional-JKN). The new decade of technology in 5.0. now is frontally change, disrupt the way people perceive, engage, and consumer branding. Technology in healthcare has also led to another significant shift in society, the need and or willingness of people to share and behavior respond to hospital brand. Study to investigate the implication of different social media in areas of gender, economic profile, ages, education and IT skill of the customers from the hospital. Analysis and result from the data collection will be based on test of the social media effect in hospital marketing mix services. The study expects that social media will improve marketing services analysis of the relationship between internet use and decision to select hospital will be shown that patients who select the hospital. This result analyzes the relationship between service, price, and decision to select hospital indicating then it can be concluded that there is a relationship between service price and decision to select a hospital.
Association and Expression of CYP2A6 and KIF12 Genes Related to Lamb Flavour and Odour

Cytochrome P450, family 2, subfamily A, polypeptide 6 (CYP2A6) and kinesin-like protein KIF12 (KIF12) genes are predicted as candidate genes which play important roles in lamb flavour and odour. The aim of this study was to analyse the genotype polymorphism of CYP2A6 and KIF12 genes, to study association and expression of these genes with lamb flavour and odour. Identification of genes polymorphism and associations of CYP2A6 and KIF12 genes were performed using PCR-RFLP method and GLM analysis. The PCR-RFLP products of CYP2A6 and KIF12 were digested by restriction enzyme BsmAI and BfaI, respectively. The expression of CYP2A6 gene was performed using qRT-PCR. The results showed that the CYP2A6 and KIF12 genes were polymorphics. The CYP2A6 gene found to have two genotypes (TT and GT), whereas the KIF12 gene found to have three genotypes (CC, CT, and TT). The CYP2A6 and KIF12 genes were in Hardy Weinberg Equilibrium (HWE). Association analysis showed that CYP2A6 (g.49170107 G>T) was significantly (P T) was not significantly associated with lamb flavour and odour. The GT genotype exhibited a greater 3-methylindole (MI) or skatole than the TT genotype (P<0.05). The mRNA expression analysis showed that CYP2A6 mRNA expression was higher (P<0.01) in animals with the TT genotype. These results will improve the understanding of the functions of the CYP2A6 in lamb flavour and odour, especially in term of 3-methylindole (MI) or skatole compound within the liver and will shed light on CYP2A6 as a candidate in the selection of sheep with low lamb flavour and odour.
Quality evaluation of Strawberry squash stored at ambient temperature

The research work was conducted to find out the effect of sodium benzoate and potassium sorbate on the overall quality of strawberry squash, stored at ambient temperature for 90 days. The research samples were numbered as T1 (strawberry squash without preservative), T2 (0.1% sodium benzoate), T3 (0.1% potassium sorbate), T4 (0.05% sodium benzoate + 0.05% potassium sorbate), T5 (0.075% sodium benzoate + 0.025% potassium sorbate). The samples were studied for pH, TSS, % acidity, ascorbic acid, reducing sugar, non-reducing sugar and organoleptic evaluation (color, flavor, taste and overall acceptability). A decrease was observed in pH (2.86 to 1.92), TSS (49.50 to 42.76), ascorbic acid content (41.75 to 24.74), non-reducing sugar (26.12 to 24.47) and an increase in % acidity (1.31 to 1.97) and reducing sugar (10.40 to 11.85). During sensory evaluation, the sample T4 (0.05% sodium benzoate + 0.05 % potassium sorbate) was found most acceptable. Statistical analysis showed that the treatments and storage intervals had a significant (P<0.05) effect on the physicochemical and organoleptic analysis of strawberry squash.
Isolation of E. coli from Bovine Mastitis and Their Antibiotic Sensitivity Pattern

Mastitis is defined as an inflammatory reaction of the parenchyma of the mammary gland that can be of an infectious, traumatic or toxic nature. It is mainly caused by microorganisms usually gram-negative and gram-positive bacteria, mycoplasmas, yeasts and algae (Zadoks et al., 2011). The multiplicity of the cause and emergence of resistance due to indiscriminate and prolonged use of antibiotics in absence of antibiogram is a major hurdle in the control of mastitis (Jeykumar et al., 2013).
INCIDENCE OF SEEDBORNE FUNGI OF SOYBEAN AND THEIR CONTROL USING MORINGA SEED EXTRACT

Seed is a basic and vital input for increased agricultural productivity as vast majority of food crops are grown from seed. Although this increased in produce by seeds have always been challenged by abiotic and biotic factors in which the biotic factors plays a major role in reducing productivity. Therefore there is a need to improve on seed quality using treated methods that are non-toxic to humans in order to maximize productivity. Thus a study was carried out at the Department of Biological Sciences, Benue State University, Makurdi to investigate the incidence of seed borne fungi in soybean and their control using Moringa seed extract. A total of four markets namely; North Bank, Wadata, Railway and Wurukum were used for the collection of soybean samples. A total of Three hundred and sixty seeds (360) were collected across the four locations and were analyzed for seed borne infection. The blotter method of fungal detection and isolation was employed for the study. Moringa seed extract was prepared at different concentration of 10, 20, 30, 40 and 50% w/v for the in vitro control of fungi isolated. The result obtained showed the presence of three fungi found associated with soybean seeds which are; Aspergillus niger, Aspergillus flavus and Rhizopus stolonifer. There was no significant difference (P>0.05) in percentage fungi occurrence across the location though North Bank market gave the highest value with 84.40% while Railway recorded the least with 58.90. Seed germination percentage showed that the seeds germination in Wadata was significantly higher (P<0.05) with 98.90% while Wurukum gave the least with 41.20%. Aspergillus niger was found to be highest in NorthBank, Railway, Wadata and Wurukum markets with 63.80, 53.30, 57.90 and 44.40% occurrence respectively. There was a significant (P<0.05) inhibitory effect of Moringa seed extract on radial mycelia fungal growth, as the concentration increased, the radial growth decreased with 50% w/v giving the highest inhibitory effect. Thus it is conclude that some fungal are associated with seeds of soybean and treatment with Moringa seed extract showed that they can be used as plant base control agents for reducing seedborne fungal infection. Therefore the government should establish industry for formulation of these extracts and used in coating seeds prior to germination to increased productivity. KeywordFungi, Incidence, radial growth, seed
MRSA/MSSA causing infections: prevalence of mecA gene

Introduction Staphylococcus aureus is part of the human flora, present in the skin and mucous membranes but can become pathogenic, causing a wide spectrum of infections that were initially treated with penicillin. However, were observed some strains with resistance to this antibiotic and, therefore was developed a new antibiotic, the methicillin. After its introduction, arose the first S. aureus with resistance to methicillin (MRSA) due to the presence of a gene known as mecA that encodes an altered penicillin binding protein (PBP2a). In Europe, it is estimated that MRSA are associated to 44% of hospital acquired infections and its mortality rate is around 20%. Objectives Prevalence of MRSA strains in different types of infection in Coimbra district. Methodology Were analysed a total of 539 isolates of S. aureus previously characterized to the antibiotic susceptibility profile in the Hospital and University Center of Coimbra. Through the minimum inhibitory concentration (MIC) of oxacillin we classified our strains into MRSA and S. aureus methicillin-sensitive (MSSA); simultaneously, the mecA gene was detected by Polymerase Chain Reaction (PCR). Results Of the 539 isolates, 49% were considered MRSA and 51% MSSA. All MRSA isolates express the mecA gene, but from the total of 276 MSSA, 191 show this gene but do not express it. MRSA isolates were mostly from respiratory tract samples (48%) and blood cultures (21%) while MSSA were isolated in skin and soft tissue samples (35%). Conclusion MRSA are considered one of the primary pathogens for the development of pneumonia and septicaemia due to its highly virulent potential and the increasing expression of genetic determinants of antimicrobial resistance. Therefore, infections caused by MRSA continue with highly representability in the clinical context and their dissemination is a public health problem.
A study on the expression of CD44 adhesion molecule in oral squamous cell carcinoma and its correlation with tumor histological grading

Background: The increasing incidence of oral squamous cell carcinoma (OSCC) combined with its poor and unchanged prognosis motivates a need for research into the aspects of tumor biology such as the expression of adhesion molecules. Alterations in the properties of adhesion molecules could play a pivotal role in the development and progression of invasive cancer and distant metastasis. Aim: This study aims to quantify the expression of cluster of differentiation 44 (CD44) in the different grades of OSCC. Materials and Methods: Immunohistochemical staining for CD44 was performed in 10 tissue sections each of normal mucosa, well-differentiated OSCC, moderately differentiated OSCC, and poorly differentiated OSCC. CD44 positivity was analyzed quantitatively in 10 representative fields of each section under 20× magnification. Statistical Analysis Used: Statistical analysis was performed using Statistical Package for Social Sciences software, version 20.0 (SPSS Inc., Chicago, IL, United States). Results: The mean value of the number of positive cells in controls was 745 ± 68.17, in well-differentiated OSCC was 694.2 ± 145.47, in moderately differentiated OSCC was 349 ± 78.40, and in poorly differentiated OSCC was 108.8 ± 34.39. Conclusion: The results of this study suggest an altered expression of CD44 in OSCC with weak immunostaining in poorly differentiated squamous cell carcinoma. Thus, it can be inferred that the loss of cell adhesion, correlated to the decrease of CD44 expression, might be of value in determining the progression of OSCC.
The Effect of Sleep Disturbance during Pregnancy on Maternal and Fetal Outcomes and its Related Nursing Management

Background: Sleep disturbance during pregnancy is an essential part of public health and a key feature of human development . Aim of this study to assess the effect of sleep disturbance during pregnancy on maternal and fetal outcomes and its related nursing management Research design: Descriptive design Setting: Ante natal care unit at El Shiekh Zaied Hospital in Cairo city-Egypt. Sample: A purposive sample consisted of hundred pregnant women was selected according to inclusion and exclusion criteria. Tool: Data was collected through an interviewing questionnaire, The Pittsburgh Sleep Quality Index and Nursing management of sleep disturbance during pregnancy. Result: This study reveals that sleep disturbance during pregnancy affect on maternal and fetal outcomes and good maternal behavior from near half pre- intervention to majority in post intervention, The difference was highly significant statistically (P=0.000). Conclusion: The present study concluded that, the sleep disturbance during pregnancy already affect on maternal and fetal outcomes as: gestational hypertension and low birth weight. As well as the many of studied pregnant women’s behavior of nursing intervention was changed improvement in posttest compared with the pretest and showed highly significant statistically between pretest and posttest (P Value 0.000). The result of this study supports the research question Recommendations: Conducting comprehensive health educational programs to raise awareness and promote women’s health during pregnancy pertaining to sleep disturbances and healthy behavior to manage them.
Yeast-to-hypha transition of Schizosaccharomyces japonicus in response to natural stimuli

Many fungal species are dimorphic, exhibiting both unicellular yeast-like and filamentous forms. Schizosaccharomyces japonicus, a member of the fission yeast clade, is one such dimorphic fungus. Here, we first identify fruit extracts as natural, stress-free, starvation-independent inducers of filamentation, which we use to describe the properties of the dimorphic switch. During the yeast-to-hypha transition, the cell evolves from a bipolar to a unipolar system with 10-fold accelerated polarized growth but constant width, vacuoles segregated to the non-growing half of the cell, and hyper-lengthening of the cell. We demonstrate unusual features of S. japonicus hyphae: these cells lack a Spitzenkörper, a vesicle distribution center at the hyphal tip, but display more rapid cytoskeleton-based transport than the yeast form, with actin cables being essential for the transition. S. japonicus hyphae also remain mononuclear and undergo complete cell divisions, which are highly asymmetric: one daughter cell inherits the vacuole, the other the growing tip. We show these elongated cells scale their nuclear size, spindle length and elongation rates but display altered division size controls. This establishes S. japonicus as a unique system that switches between symmetric and asymmetric modes of growth and division.
An Analysis of English for Specific Purposes among University Students

The study gives an account of English for Specific Purposes (ESP) within the engineering field, students’ willingness to learn professional English vocabulary, and ESP issues related to Higher Education Institutions (HEIs). The study investigates students ́ need to learn English through data analyzed in a descriptive and exploratory study, focusing on the students’ perceptions about ESP based on their English language level and ESP learning practices, and its integration within HEIs. A questionnaire was completed by 239 university students and 16 face-to-face interviews were held. The collected data were subjected to SPSS statistical analysis and the results were then analyzed and discussed. The study identified that university students can acquire professional vocabulary in English language classes, providing high levels of stimulus for future job opportunities in the engineering field. The highest priority for the students was learning ESP for employment purposes, with the primary focus being the enhancement of their communicative skills.
Optogenetic activation of SST-positive interneurons restores hippocampal theta oscillation impairment induced by soluble amyloid beta oligomers in vivo

Abnormal accumulation of amyloid β oligomers (AβO) is a hallmark of Alzheimer’s disease (AD), which leads to learning and memory deficits. Hippocampal theta oscillations that are critical in spatial navigation, learning and memory are impaired in AD. Since GABAergic interneurons, such as somatostatin-positive (SST+) and parvalbumin-positive (PV+) interneurons, are believed to play key roles in the hippocampal oscillogenesis, we asked whether AβO selectively impairs these SST+ and PV+ interneurons. To selectively manipulate SST+ or PV+ interneuron activity in mice with AβO pathology in vivo, we co-injected AβO and adeno-associated virus (AAV) for expressing floxed channelrhodopsin-2 (ChR2) into the hippocampus of SST-Cre or PV-Cre mice. Local field potential (LFP) recordings in vivo in these AβO–injected mice showed a reduction in the peak power of theta oscillations and desynchronization of spikes from CA1 pyramidal neurons relative to theta oscillations compared to those in control mice. Optogenetic-activation of SST+ but not PV+ interneurons in AβO–injected mice fully restored the peak power of theta oscillations and resynchronized the theta spike phases to a level observed in control mice. In vitro whole-cell voltage-clamp recordings in CA1 pyramidal neurons in hippocampal slices treated with AβO revealed that short-term plasticity of SST+ interneuron inhibitory inputs to CA1 pyramidal neurons at theta frequency were selectively disrupted while that of PV+ interneuron inputs were unaffected. Together, our results suggest that dysfunction in inputs from SST+ interneurons to CA1 pyramidal neurons may underlie the impairment of theta oscillations observed in AβO-injected mice in vivo. Our findings identify SST+ interneurons as a target for restoring theta-frequency oscillations in early AD.
How Observed Queue Length and Service Times Drive Queue Behavior in the Lab

Join and renege decisions from a single server, observable, first come first served queue are studied via controlled laboratory experiments. The role observed queue length and encountered service time experience plays on these decisions is explored. Reneging behavior by customers influences the performance of many service systems where waiting occurs. An understanding of the drivers of renege behavior is essential to queue design endeavors. Analysis of experiment data shows that, controlling for the total waiting time, the survival time in a queue is affected by the physical queue length as well as experienced service times. Not all subjects are affected by the physical queue length in the same way. Furthermore, this effect is partly mitigated when additional information on waiting time is provided. The experiment design that enables a comparison to a deterministic service time benchmark allows to separate the average pace (speed) set by the expected service time from a relative pace capturing the difference between realized service times and expectations. A fast relative pace is found to have a significant effect on patience which can be reduced by creating a setting that diminishes the motivation for in-queue observation.
Histological Feature of Ovarian Structures Throughout the Reproductive Cycle in Alpine Goats (Capra Hircus)

Abstract The knowledge about ovarian physiology in small ruminants is still limited, especially when compared to other domestic species. Ovarian function in goats is mainly assessed by ultrasonographic techniques, whereas a quali-quantitative feature of the follicular and luteal structures throughout the reproductive cycle in naturally cycling goats is scarce. This study provides a detailed description of the functional morphology and size of 742 ovarian structures (follicles, corpora hemorrhagica and corpora lutea) in relation to the oestrus phase, the body weight and the age of 25 Alpine goats (Capra hircus). The current study demonstrated that, the number and size of the follicles were related to the stage of the reproductive cycle (P < 0.0001). Also, the mean number of follicles was high during both prepubertal anestrus and diestrus, whereas it was low in the oestrus. Large (3-4 mm in diameter) and very large follicles (> 4 mm) (P < 0.001), and small follicles (< 2 mm; P < 0.05) varied throughout the reproductive cycle, while medium follicles (2-3 mm) were invariably observed. Large and very large follicles were predominant during the diestrus phase and small follicles in the prepubertal anestrus. It is evident from the current study that the number of follicles (P < 0.05) was significantly affected with both body weight and age. On the other hand, the size of follicles was significantly affected with body weight only (P < 0.0001). These results could contribute to a deeper understanding of ovarian transformations with important implications in assisted reproductive technologies, thereby concurring in advancing the efficiency of ultrasound in breeding programs for this species.