Miracle-dz/UniFAR-FTUs huggingface dataset:
Incidence of Epiretinal Membrane Formation After Pars Plana Vitrectomy for Giant Retinal Tear-Associated Retinal Detachment

Objective To report the incidence of postoperative epiretinal membrane (ERM) formation after primary pars plana vitrectomy (PPV) for giant retinal tear associated retinal detachment (GRT-RD) repair as well as its clinical characteristics and visual outcomes at a level one trauma and tertiary referral academic center. Patients and Methods Patients with primary RD repair for GRT-RD at West Virginia University from September 2010 to July 2021 were identified using the ICD-10 codes (H33.031, H33.032, H33.033 and H33.039). Imaging studies including optical coherence tomography (OCT) were manually reviewed pre- and post-operatively for ERM formation after PPV for GRT-RD repair in patients who underwent PPV or combined PPV and scleral buckle (SB). Univariate analysis was performed to analyze clinical factors for ERM formation. Results The study included 17 eyes of 16 patients who underwent PPV for GRT-RD. Postoperative ERM was observed in 70.6% (13 of 17 eyes) of the patients. Anatomic success was achieved in all patients. The mean (range) preoperative and final best corrected visual acuity (BCVA) in logMAR units by macula status was 0.19 (0–0.5) and 0.28 (0–0.5) for macula-on and 1.7 (0.5–2.3) and 0.7 (0.2–1.9) for macular-off GRT-RDs. Clinical variables including use of medium-term tamponade with perfluorocarbon liquid (PFCL), cryopexy, endodiathermy, number of tears or total clock hours of tears did not correlate with an increased risk of ERM formation. Conclusion Post-vitrectomized eyes for GRT-RD repair have a significantly higher incidence of ERM formation, nearing 70% in our study. Surgeons may consider prophylactic ILM peel at the time of removal of tamponade agents or weigh in ILM peel at the time of primary repair, a more challenging surgical technique in our opinion.
Storm Surges in the Region of Western Alaska

Abstract Within the period of the historical record there have been several occurrences of extensive damage from storm-surge-related coastal flooding in the region of Nome, Alaska. The most recent of these events, although by no means the most destructive, occurred in association with the storm of 5–6 October 1992. Despite the small population of Nome (approximately 4000 people), total damage costs exceeded $6 million. The research into the nature and causes of such flooding events has focused on this October 1992 case. The authors have, however, also examined a weaker, shorter-duration event that occurred on 20 August 1993 and, for contrast, a case in September 1993 where a sustained offshore wind transported water out of Norton Sound. Tide gauge data from Nome were used to quantitatively assess the associated changes in water level, and meteorological analyses were utilized to examine the associated synoptic-scale circulations and their evolution. In addition, numerical modeling experiments were conduct.
Scale-Controlled Objective Analysis

Abstract The major topic of this paper is the resolvable spatial scales that can be analyzed by statistical interpolation of an undersampled dataset. The inquiry was motivated by the need to design the most appropriate procedures for spatial analysis of the upper-air sounding data from the GARP Atlantic Tropical Experiment. A reliable representation of horizontal scales in the analyzed wind fields was a matter of utmost concern, since the derived fields of vorticity, divergence and vertical motion were also of vital interest. To achieve our goal, it was found that the traditional promise of statistical interpolation had to be reexamined. The main conclusions of this theoretical inquiry are (i) resolvable scales are determined by the geometrical distribution of observing stations; (ii) precise knowledge of the second-moment statistics improves the analysis by de-aliasing the amplitudes of resolvable scales, but has no effect on the definition of resolvable scales; (iii) residual effects of unresolvable sig.
Dynamics of a viscous thread surrounded by another viscous fluid in a cylindrical tube under the action of a radial electric field: breakup and touchdown singularities

Abstract The nonlinear dynamics of a viscous filament surrounded by a second viscous fluid arranged in a core-annular configuration when a radial electric field acts in the annular region, are studied analytically and computationally using boundary element methods. The flow is characterized by the viscosity ratio, an electric Weber number measuring the strength of the electric field, a geometrical parameter measuring the thickness of the undisturbed annular region, as well as a computational parameter that fixes the wavenumber of the undulations. Axisymmetric solutions are computed by direct numerical simulations in the Stokes limit for general values of the parameters when the two fluids have equal viscosities, and an asymptotic theory is carried out to produce a novel evolution equation for thin film dynamics valid when the undisturbed annular thickness is small and the viscosity ratio is of order one. It is established (in agreement with previous computations in the absence of electric fields) that a sufficiently thick annulus enables thread breakup while a sufficiently thin one (approximately one fifth of the undisturbed thread radius for the case of equal viscosities, for instance) suppresses pinching and drives the interface to approach the tube wall asymptotically without actually touching it. The present simulations show that the electric field affects the dynamics drastically in several ways. First, it promotes interfacial wall touchdown in finite time and a comparison between direct simulations and the asymptotic solutions are in fair agreement. Second, the electric field acts to suppress pinching in the sense that solutions that lead to jet breakup due to a thick enough viscous annulus are driven to wall touchdown. When pinching takes place we find that the ultimate pinching solutions are self-similar and recover the non-electrified ones to leading order for the range of parameters studied.
Glottal Airflow Estimation Using Neck Surface Acceleration and Low-Order Kalman Smoothing

The use of non-invasive skin accelerometers placed over the extrathoracic trachea has been proposed in the literature for measuring vocal function. Glottal airflow is estimated using inverse filtering or Bayesian techniques based on a subglottal impedance-based model when utilizing these sensors. However, deviations in glottal airflow estimates can arise due to sensor positioning and model mismatch, and addressing them requires a significant computational load. In this paper, we utilize system identification techniques to obtain a low order state-space representation of the subglottal impedance-based model. We then employ the resulting low order model in a Kalman smoother to estimate the glottal airflow. Our proposed approach reduces the model order by 94% and requires only 1.5% of the computing time compared to previous Bayesian methods in the literature, while achieving slightly better accuracy when correcting for glottal airflow deviations. Additionally, our Kalman smoother approach provides a measure of uncertainty in the airflow estimate, which is valuable when measurements are taken under different conditions. With its comparable accuracy in signal estimation and reduced computational load, the proposed approach has the potential for real-time estimation of glottal airflow and its associated uncertainty in wearable voice ambulatory monitors using neck-surface acceleration.
Numerical Investigation of Flow Control for a Flat-Window Cylindrical Turret

This work presents multiple high-fidelity large-eddy simulations of flow over a cylindrical turret with a flat window oriented at two angles, 90 and 100 deg. For the 100 deg case, additional computations were performed to investigate the effectiveness of multiple types of flow control including rows of short pins, tall pins, and steady blowing wall jets inserted upstream of the turret as well as a steady suction slot at the leading edge of the flat window. The large-eddy simulation computations were obtained using a well-validated high-order Navier–Stokes flow solver employing a sixth-order compact spatial discretization in conjunction with an eighth-order low-pass spatial filter. Overall, large-eddy simulation solutions compared favorably to experimental time mean and fluctuating velocity profiles as well as the general flow structure at both angles. Additionally, valuable insight was obtained on how rows of pins, blowing jets, and steady slot suction control flow separation. Slot suction at the upwind a.
Impact of color vision deficiency on the quality of life in a sample of Indian population: Application of the CVD-QoL tool

Purpose: To investigate the quality of life (QoL) in a sample of color vision deficit (CVD) patients in India and how color vision deficiency affects them psychologically, economically, and in productivity related to their work and occupation. Methods: A descriptive and case–control study design using a questionnaire was conducted on N = 120 participants, of whom 60 were patients of CVD (52 male and eight female) who visited two eye facilities in Hyderabad between 2020 and 2021 and 60 were age-matched normal color vision participants who served as controls. We validated English–Telugu adapted version of CVD-QoL, developed by Barry et al. in 2017 (CB-QoL). The CVD-QoL consists of 27 Likert-scale items with factors (lifestyle, emotions, and work). Color vision was assessed using the Ishihara and Cambridge Mollen color vision tests. A six-point Likert scale was used, with lower scores indicating poor QoL (from 1 = severe issue to 6 = no problem). Results: The CVD-QoL questionnaire's reliability and internal consistency were measured, including Cronbach's α (α =0.70–0.90). There was no significance between the group in age (t = −1.2, P = 0.67) whereas the Ishihara colour vision test, scores showed a significant difference (t = 4.50, P < 0.001). The QoL scores showed a significant difference towards lifestyle, emotions and work (P = 0.001). The CVD group had a poorer QoL score than the normal color vision group odds ratio [OR] =0.31, 95% confidence interval [CI], (P = 0.002, CI = 0.14–0.65, Z = 3.0) . In this analysis, a low CI indicated that the OR was more precise. Conclusion: Color vision deficiency affects Indians' QoL, according to this study. The mean scores of lifestyle, emotions, and work were lower than the UK sample.Since CVD is underreported and possibly affects developing countries more, advocacy for a new health care plan on CVD is essential. Increasing public understanding and awareness could also help diagnosing the CVD population.
A Reduced Rank Estimate of Forecast Error Variance Changes due to Intermittent Modifications of the Observing Network.

A new tool for planning adaptive observations is introduced. Different modifications of the observing network can be compared prior to the time of modification. The method predicts the variance of forecast errors projected into a low-dimensional subspace. Tangent-linear error evolution is assumed and the contribution of model errors to the forecast error is neglected. Singular vectors of the propagator of the tangent-linear version of the forecast model are used to define a relevant subspace. The method employs the Hessian of the cost function of a variational assimilation scheme to obtain information on the distribution of initial errors. Thus, this technique for planning adaptive observations can be made consistent with operational variational assimilation schemes. The application of the method is currently limited to intermittent modifications of the observing network as changes of the background error distribution due to modifications of the network in previous assimilation cycles are not accounted for. The predicted changes of forecast error variance are identical to those that the ensemble transform Kalman filter method would yield if applied to a set of Hessian singular vectors. The reduced rank estimate has been implemented in the Integrated Forecasting System of the European Centre for Medium-Range Weather Forecasts. To illustrate the scope of the method, it is applied to the 2-day forecast of an extratropical cyclone. The expected reduction of the total energy of forecast error is computed for various hypothetical adaptive networks that differ by spatial coverage, observation density, and the type of observation.
Parallel FETI‐DP algorithm for efficient simulation of large‐scale EM problems

An efficient parallelization of the dual‐primal finite‐element tearing and interconnecting (FETI‐DP) algorithm is presented for large‐scale electromagnetic simulations. As a nonoverlapping domain decomposition method, the FETI‐DP algorithm formulates a global interface problem, whose iterative solution is accelerated with a solution of a global corner problem. To achieve a good load balance for parallel computation, the original computational domain is decomposed into subdomains with similar sizes and shapes. The subdomains are then distributed to processors based on their close proximity to minimize inter‐processor communication. The parallel generalized minimal residual method, enhanced with the iterative classical Gram‐Schmidt orthogonalization scheme to reduce global communication, is adopted to solve the global interface problem with a fast convergence rate. The global corner‐related coarse problem is solved iteratively with a parallel communication‐avoiding biconjugate gradient stabilized method to minimize global communication, and its convergence is accelerated by a diagonal preconditioner constructed from the coarse system matrix. To alleviate neighboring communication overhead, the non‐blocking communication approach is employed in both generalized minimal residual and communication‐avoiding biconjugate gradient stabilized iterative solutions. Three numerical examples are presented to demonstrate the accuracy, scalability, and capability of the proposed parallel FETI‐DP algorithm for electromagnetic modeling of general objects and antenna arrays. Copyright © 2016 John Wiley & Sons, Ltd.
Differential Blood–Brain Barrier Transport and Cell Uptake of Cyclic Peptides In Vivo and In Vitro

The blood–brain barrier (BBB) poses major challenges to drug delivery to the CNS. SFTI-1 and kalata B1 are cyclic cell-penetrating peptides (cCPPs) with high potential to be used as scaffolds for drug delivery. We here studied their transport across the BBB and distribution within the brain to gauge the potential of these two cCPPs as scaffolds for CNS drugs. In a rat model, SFTI-1 exhibited, for a peptide, high extent of BBB transport with a partitioning of unbound SFTI-1 across the BBB, Kp,uu,brain, of 13%, while only 0.5% of kalata B1 equilibrated across the BBB. By contrast, kalata B1, but not SFTI-1, readily entered neural cells. SFTI-1, but not kalata B1, could be a potential CNS delivery scaffold for drugs directed to extracellular targets. These findings indicate that differences between the BBB transport and cellular uptake abilities of CPPs are crucial in the development of peptide scaffolds.
Unsupervised Domain Adaptation via Risk-Consistent Estimators

Unsupervised domain adaptation (UDA) attempts to learn domain invariant representations and has achieved significant progress, whereas self-training-based UDA methods have shown powerful performance. However, due to the domain gap, pseudo-labels selected through high confidence scores or uncertainty inevitably contain noise, leading to inaccurate predictions. To address this issue, we propose a novel risk-consistent training method. Specifically, both clean and noisy classifiers are introduced to estimate the noise transition matrix. The clean classifier is exploited to assign pseudo-labels for target data in each iteration. The noisy classifier is then trained with noisy target samples, and the optimal parameters are obtained through a closed-form solution. Heuristically, we also pre-train a domain predictor to select a target-like source example for the noise transition matrix estimation. In addition, we design an uncertainty-guided regularization to generate soft pseudo-labels and avoid overconfident predictions. Extensive experimental results show the effectiveness of our method, and state-of-the-art performance has been achieved. Codes are available at https://github.com/feifei-cv/RCE.
Towards p × n transverse thermoelectrics: extreme anisotropic conduction in bulk doped semiconductor thin films via proton implantation

Transverse thermoelectrics promise entirely new strategies for integrated cooling elements for optoelectronics. The recently introduced p × n-type transverse thermoelectric paradigm indicates that the most important step to engineering artiﬁcial transverse thermoelectrics is to create alternate p- and n-doped layers with orthogonally oriented anisotropic conductivity. This paper studies an approach to creating extreme anisotropic conductivity in bulk-doped semiconductor thin ﬁlms via ion implantation. This approach deﬁnes an array of parallel conduction channels with photolithographic patterning of an SiO2 mask layer, followed by proton implantation. With a 10 μm channel width and 20 μm pitch, both n-type and p-type Al0.42 Ga0.58As thin ﬁlms demonstrate a conductivity anisotropy ratio σ /σ⊥ > 104 at room temperature, while the longitudinal resistivity along the channel direction after implantation only increased by a factor of 3.3 ∼ 3.6. This approach can be readily adapted to other semiconductor materials for artiﬁcial p × n-type transverse thermoelectrics as other applications.
The Prevalence of Violence Against Resident Doctors and Its Subsequent Effects on Patient Management in a Tertiary Care Hospital in Delhi, India

Introduction Workplace violence (WPV) is a significant problem for healthcare professionals across the world, regardless of whether they work in developed or developing countries. Studies have shown that in India, up to 75% of doctors have experienced some form of violence in the workplace. The purpose of the present study was to examine the extent of violence against doctors and its impact on patient management. Methodology This cross-sectional study was conducted in a tertiary care hospital in New Delhi in June 2022. A total of 326 resident doctors from six departments were selected using stratified random sampling. Data were collected using a semi-structured interview schedule and a pre-validated questionnaire. Statistical analysis was done using Stata 17, and ethical clearance was obtained from the Institute Ethical Committee. Result Workplace violence was prevalent among healthcare professionals, with 80.4% (95% confidence interval (CI): 75.6%-84.5%) experiencing verbal abuse and 21.7% (95% CI: 17.4%-84.5%) experiencing physical violence. Perceived delays in treatment and patient deaths were the most common causes of violence. Most participants were hesitant to report WPV due to time-consuming reporting processes and a lack of organisational support. WPV had a negative impact on doctors' mental and personal well-being, with 73.3% reporting its negative impact. WPV has led to a decrease in the provision of surgical and medical interventions. Conclusion The study findings suggest that a significant proportion of doctors in a tertiary care hospital in Delhi encounter some form of workplace violence. Despite the high incidence of WPV, reporting of these events remains low due to inadequate support and deficient reporting procedures within healthcare organisations. The negative impact of WPV is not limited to the physicians' psycho-social well-being but extends to their approach to patient care as well. Therefore, taking appropriate actions to prevent WPV is crucial for ensuring the safety and well-being of healthcare professionals and improving patient outcomes.
Effective Stress for Saturated and Unsaturated Porous Media– A Differential Approach

Here we theoretically derive the Terzaghi stress principle for saturated and partially saturated isotropic, porous media with compressible phases. We use previously derived thermodynamic definitions of the drained and unjacketed compressibilities and total differentials to theoretically determine how the total pressure relates to isotropic strain and changes in fluid pressures. We show that under simplifying assumptions we recover the varying forms of the Biot coefficient for saturated porous media and the Bishop parameter for partially saturated porous media. We compare this approach with four modern constructions: the mixture theoretic approaches of Coussy and Borja, Wang's differential approach, and the thermodynamically constrained averaging theory approach of Gray and Schrefler. In doing so we theoretically clarify the often confused definitions of the solid compressibility coefficient, the unjacketed and drained compressibilities, and the generalized Terzaghi stress principle in differential form.
A test for the complete independence of high-dimensional random vectors

ABSTRACT This paper discusses the problem of testing the complete independence of random variables when the dimension of observations can be much larger than the sample size. It is reported that two typical tests based on, respectively, the biggest off-diagonal entry and the largest eigenvalue of the sample correlation matrix lose their control of type I error in such high-dimensional scenarios, and exhibit distinct behaviours in type II error under different types of alternative hypothesis. Given these facts, we propose a permutation test procedure by synthesizing these two extreme statistics. Simulation results show that for finite dimension and sample size the proposed test outperforms the existing methods in various cases.
Renoprotection by Inhibiting Connexin 43 Expression in a Mouse Model of Obesity-Related Renal Injury

Introduction Our previous study conducted in an obesity-related renal injury rat model have established a connection between increased connexin 43 (Cx43) expression and renal injury. In this study, we investigated whether inhibiting Cx43 expression could provide renoprotection in a mouse model of obesity-related renal injury. Methods Five-week-old C57BL/6J mice were fed with a high-fat diet for 12 weeks to establish an obesity-related renal injury model, then they were treated with Cx43 antisense oligodeoxynucleotide (AS) or scrambled oligodeoxynucleotide (SCR) by an implanted osmotic pump for 4 weeks. Finally, the glomerular filtration function, the histological change in the glomeruli, and the markers of podocyte injury (WT-1, Nephrin) and inflammatory infiltration of renal tissue (CD68, F4/80 and VCAM-1) were examined respectively. Results The results showed that inhibiting Cx43 expression by AS in this mouse model of obesity-related renal injury can effectively improve glomerular filtration function, alleviate glomerular expansion and podocyte injury, and attenuate the inflammatory infiltration of renal tissue. Conclusion Our results demonstrated that inhibiting Cx43 expression by AS could provide renoprotection for the mouse model of obesity-related renal injury.
Construction et Propriétés de Martingales des Branchements Spatiaux Interactifs@@@Construction et Proprietes de Martingales des Branchements Spatiaux Interactifs

Nous presentons une construction des processus de branchement spatiaux comme solutions de problemes de martingales dans l'espace des mesures finies sur R d . Cette approche permet d'introduire de l'interaction dans les parametres du modele (deplacement, temps de vie, reproduction) et d'etudier des proprietes asymptotiques de tels processus renormalises