Miracle-dz/UniFAR-FTUs huggingface dataset:
Role of a ! e ! a phase transformation on the spall behavior of iron at atomic scales

Shock compression of iron microstructures above a threshold stress results in a a BCC ð Þ ! e HCP ð Þ transformation, and the propagation of the release wave brings the metal back to the a phase following the e ! a transformation. Predicting failure behavior under shock loading conditions (spallation) relies on understanding the evolution of defects in the microstructure as it undergoes the a ! e ! a phase transformation. This study uses molecular dynamics (MD) simulations to investigate the role of defect evolution during the a ! e ! a phase transformation on the spall strength values of single-crystal (sc) Fe microstructures. The MD simulations aim to characterize the e phase fraction formed during shock compression and the defects during shock release for variations in loading orientations and shock stresses. The simulations are carried out for loading along the [100], [110], [111], and [112] orientations and for impact velocities ranging from 600 m/s to 1 km/s. The e phase fractions during compression and defects (dislocations, twins) characterized during spall failure show an orientation dependence that affects the spall strength values. The lowest value for spall strength is observed for the 110 loading orientation that shows a high density of twins at the spall plane, whereas the highest value is observed for the 100 orientation and is associated with a a BCC ð Þ ! c FCC ð Þ transformation at the spall plane. The correlations of the spall strength values with the strain rates and with the e phase fractions are discussed.
Apoptosis by Calpain Activation Induces Macrophage Streptococcus Group B

Group B Streptococcus (GBS) has developed several strategies to evade immune defenses. We show that GBS induces macrophage (M (cid:1) ) membrane permeability defects and apoptosis, prevented by inhibition of calcium inﬂux but not caspases. We analyze the molecular mechanisms of GBS-induced murine M (cid:1) apoptosis. GBS causes a massive intracellular calcium increase, strictly correlated to membrane permeability defects and apoptosis onset. Calcium increase was associated with activation of calcium-dependent protease calpain, demonstrated by casein zymography, (cid:2) -spectrin cleavage to a calpain-speciﬁc fragment, ﬂuorogenic calpain-substrate cleavage, and inhibition of these proteolyses by calpain inhibitors targeting the calcium-binding, 3-(4-Iodophenyl)-2-mercapto-(Z)-2-propenoic acid, or active site (four different inhibitors), by calpain small-interfering-RNA (siRNA) and EGTA. GBS-induced M (cid:1) apoptosis was inhibited by all micro- and m-calpain inhibitors used and m-calpain siRNA, but not 3-(5-Fluoro-3-indolyl)-2-mercapto-(Z)-2-propenoic acid (micro-calpain inhibitor) and micro-calpain siRNA indicating that m-calpain plays a central role in apoptosis. Calpain activation is followed by Bax and Bid cleavage, cytochrome c , apoptosis-inducing factor, and endonuclease G release from mitochondria. In GBS-induced apoptosis, cytochrome c did not induce caspase-3 and -7 activation because they and APAF-1 were degraded by calpains. Therefore, factor and endonuclease G seem the main mediators of the calpain-dependent but caspase-independent pathway of GBS-induced apoptosis. Proapoptotic mediator degradations do not occur with nonhemolytic GBS, not inducing M (cid:1) apoptosis. Apoptosis was reduced by Bax siRNA and Bid siRNA suggesting Bax and Bid degradation is apoptosis correlated. This signaling pathway, different from that of most pathogens, could represent a GBS strategy to evade immune defenses. The Journal of Immunology, 2006, 176: 7542–7556.
Patents that Match your Standards: Firm-level Evidence on Competition and Growth

When a technology becomes the new standard, the firms that are leaders in producing this technology have a competitive advantage. Matching the semantic content of patents to standards and exploiting the exogenous timing of standardization, we show that firms closer to the new technological frontier increase their market share and sales. In addition, if they operate in a very competitive market, these firms also increase their R&D expenses and investment. Yet, these effects are temporary since standardization creates a common technological basis for everyone which allows followers to catch up and the economy to grow.
Sarcoplasmic Reticulum Ca / Calmodulin-Dependent Protein Kinase II and Protein Kinase A Differentially

Toischer, David Ellenberger, Anna Förster, Jan D. Schmitto, Jan Gummert, Friedrich A. Thomas H. Fischer, Jonas Herting, Theodor Tirilomis, André Renner, Stefan Neef, Karl Leak in Human Cardiac Pathology 2+ Regulate Sarcoplasmic Reticulum Ca /Calmodulin-Dependent Protein Kinase II and Protein Kinase A Differentially 2+ Ca Print ISSN: 0009-7322. Online ISSN: 1524-4539 Copyright © 2013 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Circulation doi: 10.1161/CIRCULATIONAHA.113. 001746 2013;128:970-981; originally published online July 19, 2013; Circulation. http://circ.ahajournals. org/content/128/9/970 World Wide Web at: The online version of this article, along with updated information and services, is located on the http://circ.ahajournals. org/content/suppl/2013/07/19/CIRCULATIONAHA.113. 001746.DC1. html Data Supplement (unedited) at:
Different Responses of Solar-Induced Chlorophyll Fluorescence at the Red and Far-Red Bands and Gross Primary Productivity to Air Temperature for Winter Wheat

Solar-induced chlorophyll fluorescence (SIF) is closely related to the light-reaction process and has been recognized as a good indicator for tracking gross primary productivity (GPP). Nevertheless, it has not been widely examined how SIF and GPP respond to temperature. Here, we explored the linkage mechanisms between SIF and GPP in winter wheat based on continuous measurements of canopy SIF (cSIF), GPP, and meteorological data. To separately explore the structural and physiological mechanisms underlying the SIF–GPP relationship, we studied the temperature responses of the estimated light use efficiency (LUEp), canopy-level chlorophyll fluorescence yield (cSIFyield) and photosystem-level chlorophyll fluorescence yield (ΦF) estimated using canopy-scale remote sensing measurements. We found that GPP, red canopy SIF (cSIF688) and far-red canopy SIF (cSIF760) all exhibited a decreasing trend during overwintering periods. However, GPP and cSIF688 showed relatively more obvious changes in response to air temperature (Ta) than cSIF760 did. In addition, the LUEp responded sensitively to Ta (the correlation coefficient, r = 0.83, p-value < 0.01). The cSIFyield_688 and ΦF_688 (ΦF at 688 nm) also exhibited significantly positive correlations with Ta (r > 0.7, p-value < 0.05), while cSIFyield_760 and ΦF_760 (ΦF at 760 nm) were weakly correlated with Ta (r < 0.3, p-value > 0.05) during overwintering periods. The results also show that LUEp was more sensitive to Ta than ΦF, which caused changes in the LUEp/ΦF ratio in response to Ta. By considering the influence of Ta, the GPP estimation based on the total SIF emitted at the photosystem level (tSIF) was improved (with R2 increased by more than 0.12 for tSIF760 and more than 0.05 for tSIF688). Therefore, our results indicate that the LUEp/ΦF ratio is affected by temperature conditions and highlights that the SIF–GPP model should consider the influence of temperature.
A search for magnetic fields in Lambda Bootis stars.

Les observations, realisees avec un analyseur Zeeman Hβ, de 13 etoiles de type λ Bootis sont presentees. Aucun champ magnetique n'est detecte, sauf pour une mesure (sur quatre) de l'etoile HD 38545. La force du champ magnetique des etoiles λ Bootis est discutee.
It’s not all about the money—landowner motivation and high voltage grid development

ABSTRACT The transition to a renewable energy future requires the extensive expansion of current high voltage grids. Due to the amount of land needed for expansion, issues related to land use have led to increased grid development opposition among landowners which in turn leads to significant project planning and budget overruns. Yet knowledge about why landowners support or object to high voltage grid development is limited. In this study, we use a theory on pluralism to uncover and categorize the multiplicity of motivations of 200 individual landowners in the Netherlands. Our results indicate that only a small number of landowners who oppose grid development focus on individual monetary gain through compensation for limits on their land use. Furthermore, most landowners find the fair and equal distribution of both the advantages and disadvantages of such limits more important than individual financial compensation. As such, overcoming contentious land use issues related to high voltage grid development by way of high individual financial compensation isn’t the only solution. Highlights Land use conflicts affect expansions of high voltage grids crucial for meeting CO2 objectives Motivations of landowners are unevenly divided among different rationalities Most individual landowners do support high voltage grid developments Individual financial compensation isn’t the only solution
Global Research Trends in Irritable Bowel Syndrome: A Bibliometric and Visualized Study

Background There are about 10–23% of adults worldwide suffering from irritable bowel syndrome (IBS). Over the past few decades, there are many aspects of uncertainty regarding IBS leading to an ongoing interest in the topic as reflected by a vast number of publications, whose heterogeneity and variable quality may challenge researchers to measure their scientific impact, to identify collaborative networks, and to grasp actively researched themes. Accordingly, with help from bibliometric approaches, our goal is to assess the structure, evolution, and trends of IBS research between 2007 and 2022. Methods The documents exclusively focusing on IBS from 2007 to 2022 were retrieved from the Science Citation Index Expanded of the Web of Science Core Collection. The annual productivity of IBS research, and the most prolific countries or regions, authors, journals and resource-, intellectual- and knowledge-sharing in IBS research, as well as co-citation analysis of references and keywords were analyzed through Microsoft Office Excel 2019, CiteSpace, and VOSviewer. Results In total, 4,092 publications were reviewed. The USA led the list of countries with the most publications (1,226, 29.96%). Mayo Clinic contributed more publications than any other institution (193, 4.71%). MAGNUS SIMREN stood out as the most active and impactful scholar with the highest number of publications and the greatest betweenness centrality value. The most high-yield journal in this field was Neurogastroenterology and motility: the official journal of the European Gastrointestinal Motility Society (275, 6.72%). Gastroenterology had the most co-citations (3,721, 3.60%). Keywords with the ongoing strong citation bursts were chromogranin A, rat model, peptide YY, gut microbiota, and low-FODMAP diet, etc. Conclusion Through bibliometric analysis, we gleaned deep insight into the current status of literature investigating IBS for the first time. These findings will be useful to scholars interested in understanding the key information in the field, as well as identifying possible research frontiers.
Penpulimab, an Fc-Engineered IgG1 Anti-PD-1 Antibody, With Improved Efficacy and Low Incidence of Immune-Related Adverse Events

Background IgG4 anbibodies are deficient in stability and may contribute to tumor-associated escape from immune surveillance. We developed an IgG1 backbone anti-programmed cell death protein-1 (PD-1) antibody, penpulimab, which is designed to remove crystallizable fragment (Fc) gamma receptor (FcγR) binding that mediates antibody-dependent cell-mediated cytotoxicity (ADCC), antibody-dependent cellular phagocytosis (ADCP) and proinflammatory cytokine release. Methods Aggregation of different anti-PD-1 antibodies was tested by size exclusion chromatography, and melting temperature midpoint (Tm) and aggregation temperature onset (Tagg) were also determined. The affinity constants of penpulimab for PD-1 and human FcγRs were measured by surface plasmon resonance and biolayer interferometry. ADCC and ADCP were determined in cellular assays and antibody-dependent cytokine release (ADCR) from human macrophages was detected by ELISA. Binding kinetics of penpulimab to human PD-1 was determined by Biacore, and epitope/paratope mapping of PD-1/penpulimab was investigated using x-ray crystallography. Additionally, patients from six ongoing trials were included for analysis of immune-related adverse events (irAEs). Results Penpulimab demonstrated better stability and a lower level of host-cell protein residue compared with IgG4 backbone anti-PD-1 antibodies. As expected, penpulimab exhibited no apparent binding to FcγRIa, FcγRIIa_H131, FcγRIIIa_V158 and FcγRIIIa_F158, elicited no apparent ADCC and ADCP activities, and induced no remarkable IL-6 and IL-8 release by activated macrophages in vitro. Penpulimab was shown in the co-crystal study to bind to human PD-1 N-glycosylation site at N58 and had a slower off-rate from PD-1 versus nivolumab or pembrolizumab. Four hundred sixty-five patients were analyzed for irAEs. Fifteen (3.2%) patients had grade 3 or above irAEs. No death from irAEs was reported. Conclusions IgG1 backbone anti-PD1 antibody penpulimab has a good stability and reduced host cell protein residue, as well as potent binding to the antigen. Fc engineering has eliminated Fc-mediated effector functions of penpulimab including ADCC, ADCP and reduced ADCR, which may contribute to its more favorable safety profile. Clinical Trial Registration www.ClinicalTrials. gov, identifier: AK105-101: NCT03352531, AK105-201: NCT03722147, AK105-301: NCT03866980, AK105-202:NCT03866967, AK105-203: NCT04172571, AK105-204: NCT04172506.
Adaptive finite element methods for variational inequalities: Theory and applications in finance

Title of dissertation: Adaptive Finite Element Methods For Variational Inequalities: Theory And Applications In Finance Chen-Song Zhang Doctor of Philosophy, 2007 Dissertation directed by: Professor Ricardo H. Nochetto Department of Mathematics We consider variational inequalities (VIs) in a bounded open domain Ω ⊂ R with a piecewise smooth obstacle constraint. To solve VIs, we formulate a fullydiscrete adaptive algorithm by using the backward Euler method for time discretization and the continuous piecewise linear finite element method for space discretization. The outline of this thesis is the following. Firstly, we introduce the elliptic and parabolic variational inequalities in Hilbert spaces and briefly review general existence and uniqueness results (Chapter 1). Then we focus on a simple but important example of VI, namely the obstacle problem (Chapter 2). One interesting application of the obstacle problem is the Americantype option pricing problem in finance. We review the classical model as well as some recent advances in option pricing (Chapter 3). These models result in VIs with integro-differential operators. Secondly, we introduce two classical numerical methods in scientific computing: the finite element method for elliptic partial differential equations (PDEs) and the Euler method for ordinary different equations (ODEs). Then we combine these two methods to formulate a fully-discrete numerical scheme for VIs (Chapter 4). With mild regularity assumptions, we prove optimal a priori convergence rate with respect to regularity of the solution for the proposed numerical method (Chapter 5). Thirdly, we derive an a posteriori error estimator and show its reliability and efficiency. The error estimator is localized in the sense that the size of the elliptic residual is only relevant in the approximate noncontact region, and the approximability of the obstacle is only relevant in the approximate contact region (Chapter 6). Based on this new a posteriori error estimator, we design a time-space adaptive algorithm and multigrid solvers for the resulting discrete problems (Chapter 7). In the end, numerical results for d = 1, 2 show that the error estimator decays with the same rate as the actual error when the space meshsize and the time step tend to zero. Also, the error indicators capture the correct local behavior of the errors in both the contact and noncontact regions (Chapter 8). Adaptive Finite Element Methods for Variational Inequalities: Theory and Applications in Finance
Variations in Litterfall Dynamics, C:N:P Stoichiometry and Associated Nutrient Return in Pure and Mixed Stands of Camphor Tree and Masson Pine Forests

Litterfall, directly and indirectly, affects the soil physicochemical properties, microbial activity, and diversity of soil fauna and flora by adding organic matter and nutrients to the soil. This study explores litterfall dynamics such as litterfall production, litter decomposition rate, and associated nutrient return in three forest types, that is, camphor tree forest (CTF), Masson pine forest (MPF), and camphor tree and Masson pine mixed forest (CMF), in subtropical China. Results showed that CMF had the highest mean annual litterfall production (4.30 ± 0.22 t ha−1), which was significantly higher than that of MPF (3.41 ± 0.25 t ha−1) and CTF (3.26 ± 0.17 t ha−1). Leaf represented the major fraction of litterfall, constituting over 71% of the total litterfall mass in the three forest types. The contribution of branch litter was 16.3, 8.9, and 16.9%, and miscellaneous litter was 12.6, 18.9, and 11.1% in CTF, MPF, and CMF, respectively. The concentration of macronutrients ranked as N > Ca > K > Mg > P in all litter fractions. The total annual macronutrient return to the soil from the litterfall was in order as CTF (74.2 kg ha−1‧yr−1) > CMF (70.7 kg ha−1‧yr−1) > MPF (33.6 kg ha−1‧yr−1). The decomposition rate was higher in leaf litter than in branch litter throughout the three forests. Among the forest types, the leaf and branch decomposition rates were in a pattern: CTF > CMF > MPF. The ratio of C/N in both leaf and branch litters was significantly higher in MPF than in CTF and CMF, while no significant differences in N/P ratio were found in these litters among the three forests. The high N:P ratios in leaf litter (23/30) and the branch (24/32) litter indicated the high N returning and low nutrient returning to the soil. Our results suggested that the broadleaved forests have faster litter decomposition and higher macronutrient returns than conifer forests. Moreover, the litter decomposition rate was mainly associated with litterfall quality and chemical composition. The introduction of broadleaved trees into monoculture coniferous stands could increase litter production nutrients return, and thus, it had advantages in soil nutrients restoration and sustainable forest management.
Increased Complexity of a Human-Robot Collaborative Task May Increase the Need for a Socially Competent Robot

An important factor in developing control models for human-robot collaboration is how acceptable they are to their human partners. One such method for creating acceptable control models is to attempt to mimic human-like behaviour in robots so that their actions appear more intuitive to humans. To investigate how task complexity affects human perception and acceptance of their robot partner, we propose a novel human-based robot control model for obstacle avoidance that can account for the leader-follower dynamics that normally occur in human collaboration. The performance and acceptance of the proposed control method were evaluated using an obstacle avoidance scenario in which we compared task performance between individual tasks and collaborative tasks with different leader-follower dynamics roles for the robotic partner. The evaluation results showed that the robot control method is able to replicate human behaviour to improve the overall task performance of the subject in collaboration. However, regarding the acceptance of the robotic partner, the participants’ opinions were mixed. Compared to the results of a study with a similar control method developed for a less complex task, the new results show a lower acceptance of the proposed control model, even though the control method was adapted to the more complex task from a dynamic standpoint. This suggests that the complexity of the collaborative task at hand increases the need not only for a more complex control model but also a more socially competent control model.
A Review on Medicinal Plants Used in the Management of Respiratory Problems in Ethiopia over a Twenty-Year Period (2000–2021)

This review is aimed at assessing and compiling the different ethnomedicinal studies in different parts of Ethiopia used to treat respiratory diseases. The data were collected from different published research papers through searching the web sources such as PubMed, Science Direct, Google Scholar, and other related websites. The important search terminologies included ethnobotany, respiratory diseases, medicinal plants, and Ethiopia. For this, a total of 65 articles of recent publications (from 2000 to May 2021 years) that provided full information about the use of medicinal plant species to treat respiratory disorder diseases in Ethiopia were consulted. Based on this, a total of 96 medicinal plants belonging to 57 families were reviewed. The commonly recorded families used to manage respiratory problems were Asteraceae, Lamiaceae, Solanaceae, and Fabaceae. Herbs and shrubs were the dominant plant growth forms. Due to the easiest form of their preparation for treating respiratory disorders, leaves are the most cited plant parts followed by roots. Crushing and pounding are useful methods of remedy preparation to treat respiratory diseases. This review concluded that different medicinal plants have a significant contribution in combating serious respiratory problems in Ethiopia. Hence, the complied review of medicinal plants on the treatment of respiratory problems would play a great role in further pharmacological and phytochemical investigations in developing new drugs used for the treatment of respiratory problems and in the conservation of these important medicinal plants.