Miracle-dz/UniFAR-FTUs huggingface dataset:
DIFFUSE γ-RAY EMISSION FROM UNRESOLVED BL LAC OBJECTS

Blazars, active galactic nuclei with a jet pointing toward the Earth, represent the most abundant class of high-energy extragalactic γ-ray sources. The subset of blazars known as BL Lac objects is on average closer to Earth (i.e., younger) and characterized by harder spectra at high energy than the whole sample. The fraction of BL Lacs that is too dim to be detected and resolved by current γ-ray telescopes is therefore expected to contribute to the high-energy isotropic diffuse γ-ray background (IGRB). The IGRB has been recently measured over a wide energy range by the Large Area Telescope (LAT) on board the Gamma-ray Space Telescope (Fermi). We present a new prediction of the diffuse γ-ray flux due to the unresolved BL Lac blazar population. The model is built upon the spectral energy distribution and the luminosity function derived from the fraction of BL Lacs detected (and spectrally characterized) in the γ-ray energy range. We focus our attention on the GeV energy range, predicting the emission up to the TeV scale and taking into account the absorption on the extragalactic background light. In order to better shape the BL Lac spectral energy distribution, we combine the Fermi-LAT data with Imaging Atmospheric Cerenkov Telescope measurements of the most energetic sources. Our analysis is carried on separately for low- and intermediate-synchrotron-peaked BL Lacs on the one hand and high-synchrotron-peaked BL Lacs on the other hand: we find in fact statistically different features for the two. The diffuse emission from the sum of both BL Lac classes increases from about 10% of the measured IGRB at 100 MeV to ∼100% of the data level at 100 GeV. At energies greater than 100 GeV, our predictions naturally explain the IGRB data, accommodating their softening with increasing energy. Uncertainties are estimated to be within of a factor of two of the best-fit flux up to 500 GeV.
Persistent COVID-19 symptoms 1 year after hospital discharge: A prospective multicenter study

Objective To determine the health status and exercise capacity of COVID-19 survivors one year after hospital discharge. Methods This multicenter prospective study included COVID-19 survivors 12 months after hospital discharge. Participants were randomly selected from a large cohort of COVID-19 patients who had been hospitalized until 15th April 2020. They were interviewed about persistent symptoms, underwent a physical examination, chest X-ray, and a 6-minute walk test (6MWT). A multivariate analysis was performed to determine the risk factors for persistent dyspnea. Results Of the 150 patients included, 58% were male and the median age was 63 (IQR 54–72) years. About 82% reported ≥1 symptoms and 45% had not recovered their physical health. The multivariate regression analysis revealed that the female sex, chronic obstructive pulmonary disease, and smoking were independent risk factors for persistent dyspnea. Approximately 50% completed less than 80% of the theoretical distance on the 6MWT. Only 14% had an abnormal X-ray, showing mainly interstitial infiltrates. A third of them had been followed up in outpatient clinics and 6% had undergone physical rehabilitation. Conclusion Despite the high rate of survivors of the first wave of the COVID-19 pandemic with persistent symptomatology at 12 months, the follow-up and rehabilitation of these patients has been really poor. Studies focusing on the role of smoking in the persistence of COVID-19 symptoms are lacking.
Some Remarks on G-Metric Spaces and Fixed Point Theorems

We notice some remarks on G -metric spaces and the fixed point results of contractive mappings defined on such spaces. Our results generalize, extend and complement recent fixed point theorems established by Jleli and Samet [M. Jleli and B. Samet, Remarks on G-metric spaces and fixed point theorems, Fixed Point Theory Appl. 2012:210 (2012)].
Environment‐triggered demographic changes cascade and compound to propel a dramatic decline of an Antarctic seabird metapopulation

While seabirds are well‐known for making a living under some of the harshest conditions on the planet, their capacity to buffer against unfavourable conditions can be stretched in response to ecosystem change. During population increases, overlap between conspecifics can limit population growth through competition for breeding or feeding resources. What is less well understood is the role that intrinsic processes play during periods of population decline or under a changing environment. We interrogate key demographic parameters and their biophysical drivers to understand the role of intrinsic and extrinsic drivers during a recent near halving of a large Adélie penguin (Pygoscelis adeliae) metapopulation. The loss of 154,000 breeding birds along the 100‐km East Antarctic coastline centred around 63°E over the last decade diverges from a sustained increase over preceding decades and is contrary to recent models that predict a continued increase. The decline was initially triggered by changed environmental conditions: more extensive near‐shore sea ice caused a reduction in breeding success. The evidence suggests this decline was exacerbated by feedback processes driving an inverse density‐dependent decrease in fledgling survival in response to smaller cohort size. It appears that the old adage of safety in numbers may shape the fledgling penguins' chances of survival and, if compromised over multiple years, could exacerbate difficulties during population decline or if feedback processes arise. The likely interplay between demographic parameters meant that conditions were more unfavourable and negative effects more rapid than would be expected if demographic processes acted in isolation or independently. Failure to capture both intrinsic and extrinsic drivers in predictive population models may mean that the real impacts of climate change on species' populations are more severe than projections would lead us to believe. These results improve our understanding of population regulation during periods of rapid decline for long‐lived marine species.
Clinical value of deep vein thrombosis density on pre-contrast and post-contrast lower-extremity CT for prediction of pulmonary thromboembolism

Background There was a lack of studies assessing the relationship between deep vein thrombosis (DVT) Hounsfield unit (HU) density and pulmonary thromboembolism (PTE). Purpose To evaluate the clinical value of DVT density measured on pre- and post-contrast lower-extremity computed tomography (CT) for the prediction of PTE. Material and Methods From 2017 to 2021, patients who underwent pulmonary CT angiography within one week after diagnosis of DVT on lower-extremity CT were included in this retrospective study. Then, the patients without PTE were included in “DVT group” and those with both DVT and PTE were included in the “DVT-PTE group. ” The DVT HU density was measured by drawing free-hand region of interests (ROIs) within the thrombus at the most proximal filling defect level. A receiver operating characteristic (ROC) analysis was used to evaluate the predictive value of DVT density for the risk of PTE. Results This study included a total of 94 patients (DVT group: n=56; DVT-PTE group: m=38). DVT density was significantly higher in the DVT-PTE group than the DVT group in both pre-contrast (53.5 ± 6.2 HU vs. 44.1 ± 7.9 HU; P < 0.001) and post-contrast CT (67.0 ± 8.6 HU vs. 57.1 ± 10.6 HU; P < 0.001). ROC analysis revealed that the area under curve, sensitivity, and specificity for predicting the risk of PTE were 0.739, 71.1%, and 64.2%, respectively, at a DVT density cutoff of 48.2 HU on pre-contrast CT and were 0.779, 73.7%, and 69.6% at a DVT density cutoff of 61.8 HU on post-contrast CT. Conclusion The DVT density on both pre- and post-contrast CT could be a predictive factor of PTE.
Volatile snowlines in embedded disks around low-mass protostars

(Abridged*) Models of the young solar nebula assume a hot initial disk with most volatiles are in the gas phase. The question remains whether an actively accreting disk is warm enough to have gas-phase water up to 50 AU radius. No detailed studies have yet been performed on the extent of snowlines in an embedded accreting disk (Stage 0). Quantify the location of gas-phase volatiles in embedded actively accreting disk system. Two-dimensional physical and radiative transfer models have been used to calculate the temperature structure of embedded protostellar systems. Gas and ice abundances of H$_2$O, CO$_2$, and CO are calculated using the density-dependent thermal desorption formulation. The midplane water snowline increases from 3 to 55 AU for accretion rates through the disk onto the star between $10^{-9}$-$10^{-4} \ M_{\odot} \ {\rm yr^{-1}}$. CO$_2$ can remain in the solid phase within the disk for $\dot{M} \leq 10^{-5} \ M_{\odot} \ {\rm yr^{-1}}$ down to $\sim 20$ AU. Most of the CO is in the gas phase within an actively accreting disk independent of disk properties and accretion rate. The predicted optically thin water isotopolog emission is consistent with the detected H$_2^{18}$O emission toward the Stage 0 embedded young stellar objects, originating from both the disk and the warm inner envelope (hot core). An accreting embedded disk can only account for water emission arising from $R < 50$ AU, however, and the extent rapidly decreases for low accretion rates. Thus, the radial extent of the emission can be measured with ALMA observations and compared to this limit. Volatiles sublimate out to 50 AU in young disks and can reset the chemical content inherited from the envelope in periods of high accretion rates. A hot young solar nebula out to 30 AU can only have occurred during the deeply embedded Stage 0, not during the T-Tauri phase of our early solar system.
Foster children’s perspectives on participation in child welfare processes: A meta-synthesis of qualitative studies

The objective of this meta-synthesis was to systematically synthesise qualitative research that explores foster children’s perspectives on participation in child welfare processes. Searches were conducted in Medline (OVID), Embase, PsycINFO, and Social Science Citation Index. Children in non-kinship foster care in any setting (high-income, middle-income, low-income countries) who self-reported their experiences of care (removal from home, foster family processes, placement breakdown) were eligible for inclusion. Selected studies took place in 11 high-income countries. A total of 8436 citations were identified and 25 articles were included in this meta-synthesis. Studies summarized the views of 376 children. Children had been in foster care between two weeks and 17 years. Findings synthesize ‘facets’ of children’s participation (e.g., being asked vs making decisions), as well as children’s perceived barriers and facilitators to participation. A main priority for children was the quality of their relationships, especially in terms of values (e.g., fairness, honesty, inclusivity). No one way of participating in child welfare processes is better than another, as some children more clearly expressed a desire for passive listening roles and others indicated a desire for active roles in decision-making. However, meaningful adults in foster children’s lives have a responsibility to act in a way that strengthens the emphasis on children’s needs and voices.
Mutual information as an order parameter for quantum synchronization

Spontaneous synchronization is a fundamental phenomenon, important in many theoretical studies and applications. Recently, this effect has been analyzed and observed in a number of physical systems close to the quantum-mechanical regime. In this work we propose mutual information as a useful order parameter which can capture the emergence of synchronization in very different contexts, ranging from semiclassical to intrinsically quantum-mechanical systems. Specifically, we first study the synchronization of two coupled Van der Pol oscillators in both classical and quantum regimes and later we consider the synchronization of two qubits inside two coupled optical cavities. In all these contexts, we find that mutual information can be used as an appropriate figure of merit for determining the synchronization phases independently of the specific details of the system.
Postural-respiratory function of the diaphragm assessed by M-mode ultrasonography

Objectives The diaphragm changes position and respiratory excursions during postural loading. However, it is unclear how it reacts to lifting a load while breath-holding or breathing with simultaneous voluntary contraction of the abdominal muscles (VCAM). This study analyzed diaphragm motion in healthy individuals during various postural-respiratory situations. Methods 31 healthy participants underwent examination of the diaphragm using M-mode ultrasonography, spirometry, and abdominal wall tension (AWT) measurements. All recordings were performed simultaneously during three consecutive scenarios, i.e., 1. Lifting a load without breathing; 2. Lifting a load and breathing naturally; 3. Lifting a load and breathing with simultaneous VCAM. Results Using paired-samples t-tests, lifting a load without breathing displaced the diaphragm’s expiratory position more caudally (P < .001), with no change noted in the inspiratory position (P = .373). During lifting a load breathing naturally, caudal displacement of the diaphragm’s inspiratory position was presented (P < .001), with no change noted in the expiratory position (P = 0.20) compared to tidal breathing. Total diaphragm excursion was greater when loaded (P = .002). Lifting a load and breathing with VCAM demonstrated no significant changes in diaphragm position for inspiration, expiration, or total excursion compared to natural loaded breathing. For all scenarios, AWT measures were greater when lifting a load (P < .001). Conclusion In healthy individuals, caudal displacement and greater excursions of the diaphragm occurred when lifting a load. The postural function of the diaphragm is independent of its respiratory activity and is not reduced by the increase in AWT.
Factors that influence genetic counselors' participation in research

Genetic counselors have skills and expertise in genetics and patient care that make them an asset to research and research teams. However, the National Society of Genetic Counselors (NSGC) found in 2020 that more than half of practicing genetic counselors do not participate in research activities. Information describing factors that influence their research participation is lacking in the literature. This study ascertained genetic counselors' workplace and graduate training experiences to provide insight into factors that increase or decrease participation in research activities. A survey was distributed through the NSGC Student Research Survey Program. Practicing genetic counselors that graduated in or before 2020 were eligible to participate. The survey included questions about demographics, implementation of student research projects, research‐specific resources in their graduate programs, perceived barriers and motivations, and current research activities. Interestingly, the majority of respondents participated in research activities between 2017 and 2021; the most common activities included: recognizing a gap(s) in knowledge (68%) and presenting an abstract or poster (64%). Factors that most significantly influenced genetic counselors' research participation included their interest in research (p = 0.0037), their motivation to do research (p = 0.0014), and their perceived intimidation by the research process (p < 0.001). These results provide insight into solutions for the workplace and graduate programs that could increase genetic counselors' research participation.
Genomic Analysis of MSM Rectal Chlamydia trachomatis Isolates Identifies Predicted Tissue-Tropic Lineages Generated by Intraspecies Lateral Gene Transfer-Mediated Evolution

Chlamydia trachomatis is an obligate intracellular bacterium that causes serious diseases in humans. Rectal infection and disease caused by this pathogen are important yet understudied aspects of C. trachomatis natural history. ABSTRACT Chlamydia trachomatis is an obligate intracellular bacterium that causes serious diseases in humans. Rectal infection and disease caused by this pathogen are important yet understudied aspects of C. trachomatis natural history. The University of Washington Chlamydia Repository has a large collection of male-rectal-sourced strains (MSM rectal strains) isolated in Seattle, USA and Lima, Peru. Initial characterization of strains collected over 30 years in both Seattle and Lima led to an association of serovars G and J with male rectal infections. Serovar D, E, and F strains were also collected from MSM patients. Genome sequence analysis of a subset of MSM rectal strains identified a clade of serovar G and J strains that had high overall genomic identity. A genome-wide association study was then used to identify genomic loci that were correlated with tissue tropism in a collection of serovar-matched male rectal and female cervical strains. The polymorphic membrane protein PmpE had the strongest correlation, and amino acid sequence alignments identified a set of PmpE variable regions (VRs) that were correlated with host or tissue tropism. Examination of the positions of VRs by the protein structure-predicting Alphafold2 algorithm demonstrated that the VRs were often present in predicted surface-exposed loops in both PmpE and PmpH protein structure. Collectively, these studies identify possible tropism-predictive loci for MSM rectal C. trachomatis infections and identify predicted surface-exposed variable regions of Pmp proteins that may function in MSM rectal versus cervical tropism differences.
Culturally grounded strategies for suicide and alcohol risk prevention delivered by rural Alaska Native communities: A dynamic wait-listed design evaluation of the Qungasvik intervention.

We examined the effectiveness of the Qungasvik (Tools for Life) intervention in enhancing protective factors as a universal suicide and alcohol prevention strategy for young people ages 12-18 living in highly affected rural Alaska Native communities. Four communities were assigned to immediate intervention or to a dynamic wait list. Outcomes were analyzed for 239 young people at four time points over two years of community intervention. Outcomes assessed two ultimate variable protective factors buffering suicide and alcohol risk, and three intermediate variable protective factors at the individual, family, and community level. Dose dependent intervention effects were associated with growth in ultimate but not intermediate variables. This evaluation of the Qungasvik intervention provides support for the effectiveness of its Indigenous strategies for suicide and alcohol misuse prevention in this rural Alaska Native setting. Though findings did not provide support for a theory of change where growth in ultimate variables is occasioned through effects on intermediate variables, research designs focused on young people who enter intervention at lower levels of preexisting protection hold promise for better understanding of intervention change processes. The Qungasvik intervention is responsive to an acute public health need for effective rural Alaska Native suicide and alcohol risk prevention strategies.
Probing the nature of the pre-merging system Hickson Compact Group 31 through integral field unit data

We present a study of the kinematics and the physical properties of the central region of the Hickson Compact Group 31 (HCG 31), focusing on the HCG 31A+ C system, using integral field spectroscopy data taken with the Gemini South Telescope. The main players in the merging event (galaxies A and C) are two dwarf galaxies, which have had one close encounter, given the observed tidal tails, and may now be in their second approach, and are possibly about to merge. We present new velocity fields and H alpha emission, stellar continuum, velocity dispersion, electron density, H alpha equivalent-width and age maps. Considering the high spatial resolution of the integral field unit data, we were able to measure various components and estimate their physical parameters, spatially resolving the different structures in this region. Our main findings are the following: (1) We report for the first time the presence of a super stellar cluster next to the burst associated with the HCG 31C central blob, related to the high values of velocity dispersion observed in this region as well as to the highest value of stellar continuum emission. This may suggest that this system is cleaning its environment through strong stellar winds that may then trigger a strong star formation event in its neighbourhood. (2) Among other physical parameters, we estimate L(H alpha) similar to 14 x 10(41) erg s(-1) and the star formation rate, SFR similar to 11 M-circle dot yr(-1) for the central merging region of HCG 31A+ C. These values indicate a high star formation density, suggesting that the system is part of a merging object, supporting previous scenarios proposed for this system.
Sleep and wake in a model of the thalamocortical system with Martinotti cells.

The mechanisms leading to the alternation between active (UP) and silent (DOWN) states during sleep slow waves (SWs) remain poorly understood. Previous models have explained the transition to the DOWN state by a progressive failure of excitation due to the build-up of adaptation currents or synaptic depression. However, these models are at odds with recent studies suggesting a role for presynaptic inhibition by Martinotti cells (MaCs) in generating SWs. Here, we update a classical large-scale model of sleep SWs to include MaCs and propose a different mechanism for the generation of SWs. In the wake mode, the network exhibits irregular and selective activity with low firing rates. Following an increase in the strength of background inputs, and a modulation of synaptic strength and potassium leak potential mimicking the reduced effect of acetylcholine during sleep, the network enters a sleep-like regime in which local increases of network activity trigger bursts of MaC activity, resulting in strong disfacilitation of the local network via presynaptic GABAB1a -type inhibition. This model replicates findings on slow wave activity during sleep that challenge previous models, including low and skewed firing rates that are comparable between the wake and sleep modes, higher synchrony of transitions to DOWN states than to UP states, the possibility of triggering SWs by optogenetic stimulation of MaCs, and the local dependence of slow wave activity on synaptic strength. Overall, this work points to a role for presynaptic inhibition by MaCs in the generation of DOWN states during sleep.