Miracle-dz/UniFAR-FTUs huggingface dataset:
Anxiety and Suicidal Thoughts During the COVID-19 Pandemic: Cross-Country Comparative Study Among Indonesian, Taiwanese, and Thai University Students

Background The COVID-19 pandemic has negatively affected the mental health of university students. Objective This study examined the psychological responses toward COVID-19 among university students from 3 countries—Indonesia, Taiwan, and Thailand. Methods We used a web-based, cross-sectional survey to recruit 1985 university students from 5 public universities (2 in Indonesia, 1 in Thailand, and 1 in Taiwan) via popular social media platforms such as Facebook, LINE, WhatsApp, and broadcast. All students (n=938 in Indonesia, n=734 in Thailand, and n=313 in Taiwan) answered questions concerning their anxiety, suicidal thoughts (or sadness), confidence in pandemic control, risk perception of susceptibility to infection, perceived support, resources for fighting infection, and sources of information in the context of the COVID-19 pandemic. Results Among the 3 student groups, Thai students had the highest levels of anxiety but the lowest levels of confidence in pandemic control and available resources for fighting COVID-19. Factors associated with higher anxiety differed across countries. Less perceived satisfactory support was associated with more suicidal thoughts among Indonesian students. On the other hand, Taiwanese students were more negatively affected by information gathered from the internet and from medical staff than were Indonesian or Thai students. Conclusions Our findings suggest that health care providers in Thailand may need to pay special attention to Thai university students given that high levels of anxiety were observed in this study population. In addition, health care providers should establish a good support system for university students, as the results of this study indicate a negative association between support and suicidal thoughts.
Learning from urban form to predict building heights

Understanding cities as complex systems, sustainable urban planning depends on reliable high-resolution data, for example of the building stock to upscale region-wide retrofit policies. For some cities and regions, these data exist in detailed 3D models based on real-world measurements. However, they are still expensive to build and maintain, a significant challenge, especially for small and medium-sized cities that are home to the majority of the European population. New methods are needed to estimate relevant building stock characteristics reliably and cost-effectively. Here, we present a machine learning based method for predicting building heights, which is based only on open-access geospatial data on urban form, such as building footprints and street networks. The method allows to predict building heights for regions where no dedicated 3D models exist currently. We train our model using building data from four European countries (France, Italy, the Netherlands, and Germany) and find that the morphology of the urban fabric surrounding a given building is highly predictive of the height of the building. A test on the German state of Brandenburg shows that our model predicts building heights with an average error well below the typical floor height (about 2.5 m), without having access to training data from Germany. Furthermore, we show that even a small amount of local height data obtained by citizens substantially improves the prediction accuracy. Our results illustrate the possibility of predicting missing data on urban infrastructure; they also underline the value of open government data and volunteered geographic information for scientific applications, such as contextual but scalable strategies to mitigate climate change.
Quantifying capital vs. income breeding: new promise with stable isotope measurements of individual amino acids.

Capital breeders accumulate nutrients prior to egg development, then use these stores to support offspring development. In contrast, income breeders rely on local nutrients consumed contemporaneously with offspring development. Understanding such nutrient allocations is critical to assessing life-history strategies and habitat use. Despite the contrast between these strategies, it remains challenging to trace nutrients from endogenous stores or exogenous food intake into offspring. Here, we tested a new solution to this problem. Using tissue samples collected opportunistically from wild emperor penguins (Aptenodytes forsteri), which exemplify capital breeding, we hypothesized that the stable carbon (δ13 C) and nitrogen (δ15 N) isotope values of individual amino acids (AA) in endogenous stores (e.g., muscle) and in egg yolk and albumen reflect the nutrient sourcing that distinguishes capital versus income breeding. Unlike other methods, this approach does not require untested assumptions or diet sampling. We found that over half of essential AA had δ13 C values that did not differ between muscle and yolk or albumen, suggesting that most of these AA were directly routed from muscle into eggs. In contrast, almost all non-essential AA differed in δ13 C values between muscle and yolk or between muscle and albumen, suggesting de novo synthesis. Over half of AA that have labile nitrogen atoms (i.e., "trophic" AA) had higher δ15 N values in yolk and albumen than in muscle, suggesting that they were transaminated during their routing into egg tissue. This effect was smaller for AA with less labile nitrogen atoms (i.e., "source" AA). Our results indicate that the δ15 N offset between trophic-source AA (Δ15 Ntrophic-source ) may provide an index of the extent of capital breeding. The value of emperor penguin Δ15 NPro-Phe was higher in yolk and albumen than in muscle, reflecting the mobilization of endogenous stores; in comparison, the value of Δ15 NPro-Phe was similar across muscle and egg tissue in previously-published data for income-breeding herring gulls (Larus argentatus smithsonianus). Our results provide a quantitative basis for using AA δ13 C and δ15 N, and isotopic offsets among AA (e.g., Δ15 NPro-Phe ), to explore the allocation of endogenous versus exogenous nutrients across the capital versus income spectrum of avian reproduction.
The Pediatric Endotracheal Aspirate Culture Survey (PETACS): Examining Practice Variation across Pediatric Microbiology Laboratories in the United States

In the absence of evidence-based laboratory guidelines, the workup and interpretation of tracheal aspirate (TA) cultures remains controversial and confusing within the fields of clinical microbiology, infectious diseases, and critical care. Between 22 January and 24 February 2020, we conducted a national, web-based survey of microbiology laboratory personnel in free-standing pediatric hospitals and adult hospitals containing pediatric facilities regarding the laboratory practices used for TA specimens. ABSTRACT In the absence of evidence-based laboratory guidelines, the workup and interpretation of tracheal aspirate (TA) cultures remains controversial and confusing within the fields of clinical microbiology, infectious diseases, and critical care. Between 22 January and 24 February 2020, we conducted a national, web-based survey of microbiology laboratory personnel in free-standing pediatric hospitals and adult hospitals containing pediatric facilities regarding the laboratory practices used for TA specimens. We hypothesized there would be substantial center-level variability in laboratory processing of TA cultures. The response rate for the survey was 48% (73/153). There was a high level of variability in the criteria used for all processes, including specimen receipt, Gram staining, and culture reporting. Most respondents (77%) reported they do not reject TA specimens based on Gram stain criteria, and 44% of labs do not require that a minimum number of Gram stain fields be reviewed prior to reporting results. Overall, nonacademic hospital laboratories and pediatric-only laboratories are more likely to identify, report, and perform susceptibility testing on organisms from TA cultures, regardless of organism quantity or predominance. There is a substantial amount of process variability among pediatric microbiology laboratories that affects TA culture reporting, and which guides treatment decisions. This variation within and among labs makes clinical outcome studies related to TA cultures difficult to interpret. This study serves as a pragmatic step in informing the development of robust clinical guidelines. Clinical outcome and implementation studies are necessary to determine the effectiveness of guidelines for TA cultures.
The Intimate Relationship among EMT, MET and TME: A T(ransdifferentiation) E(nhancing) M(ix) to Be Exploited for Therapeutic Purposes

Simple Summary Intratumoral heterogeneity is considered the major cause of drug resistance and hence treatment failure in cancer patients. Tumor cells are known for their phenotypic plasticity that is the ability of a cell to reprogram and change its identity to eventually adopt multiple phenotypes. Tumor cell plasticity involves the reactivation of developmental programs, the acquisition of cancer stem cell properties and an enhanced potential for retro- or transdifferentiation. A well-known transdifferentiation mechanism is the process of epithelial-mesenchymal transition (EMT). Current evidence suggests a complex interplay between EMT, genetic and epigenetic alterations, and various signals from the tumor microenvironment (TME) in shaping a tumor cell’s plasticity. The vulnerabilities exposed by cancer cells when residing in a plastic or stem-like state have the potential to be exploited therapeutically, i.e., by converting highly metastatic cells into less aggressive or even harmless postmitotic ones. Abstract Intratumoral heterogeneity is considered the major cause of drug unresponsiveness in cancer and accumulating evidence implicates non-mutational resistance mechanisms rather than genetic mutations in its development. These non-mutational processes are largely driven by phenotypic plasticity, which is defined as the ability of a cell to reprogram and change its identity (phenotype switching). Tumor cell plasticity is characterized by the reactivation of developmental programs that are closely correlated with the acquisition of cancer stem cell properties and an enhanced potential for retrodifferentiation or transdifferentiation. A well-studied mechanism of phenotypic plasticity is the epithelial-mesenchymal transition (EMT). Current evidence suggests a complex interplay between EMT, genetic and epigenetic alterations, and clues from the tumor microenvironment in cell reprogramming. A deeper understanding of the connections between stem cell, epithelial–mesenchymal, and tumor-associated reprogramming events is crucial to develop novel therapies that mitigate cell plasticity and minimize the evolution of tumor heterogeneity, and hence drug resistance. Alternatively, vulnerabilities exposed by tumor cells when residing in a plastic or stem-like state may be exploited therapeutically, i.e., by converting them into less aggressive or even postmitotic cells. Tumor cell plasticity thus presents a new paradigm for understanding a cancer’s resistance to therapy and deciphering its underlying mechanisms.
Weather and Aggressive Behavior among Patients in Psychiatric Hospitals—An Exploratory Study

Background: The number of meteoropaths, or people negatively affected by weather conditions, is rising dramatically. Meteoropathy is developing rapidly due to ever poorer adaptations of people to changes in weather conditions. Strong weather stimuli may not only exacerbate symptoms in people with diseases of the cardiovascular and respiratory systems but may also induce aggressive behavior. Researchers have shown that patients suffering from mental illnesses are most vulnerable to changes in the weather and postulate a connection between the seasons and aggressive behavior. Methods: The goal of the study was to analyze the relationship between coercive measures and weather factors. The researchers identified what meteorological conditions prevailed on days with an increased number of incidents of aggressive behavior leading to the use of physical coercion towards patients in a psychiatric hospital in Poland. In order to determine the impact of weather conditions on the frequency at which physical coercion measures were used, the hospital’s “coercion sheets” from 1 January 2015 to 31 March 2017 were analyzed. The data were correlated with meteorological data. In order to determine the relationship between the occurrence of specific weather conditions and the number of coercive interventions (N), researchers utilized Spearman’s rank correlation analysis together with two-dimensional scatter diagrams (dependency models), multiple regression, stepwise regression, frequencies, and conditional probability (%). Results: Lower barometric pressure and foehn wind increased aggressive behavior in patients that led to coercive measures. For temperature (positive correlation) and humidity (negative correlation), there was a poor but statistically significant correlation. Conclusions: Monitoring weather conditions might be useful in predicting and preventing aggression by patients who are susceptible to weather changes
Lamin B1 decline underlies age‐related loss of adult hippocampal neurogenesis

Neurogenesis in the adult hippocampus declines with age, a process that has been implicated in cognitive and emotional impairments. However, the mechanisms underlying this decline have remained elusive. Here, we show that the age‐dependent downregulation of lamin B1, one of the nuclear lamins in adult neural stem/progenitor cells (ANSPCs), underlies age‐related alterations in adult hippocampal neurogenesis. Our results indicate that higher levels of lamin B1 in ANSPCs safeguard against premature differentiation and regulate the maintenance of ANSPCs. However, the level of lamin B1 in ANSPCs declines during aging. Precocious loss of lamin B1 in ANSPCs transiently promotes neurogenesis but eventually depletes it. Furthermore, the reduction of lamin B1 in ANSPCs recapitulates age‐related anxiety‐like behavior in mice. Our results indicate that the decline in lamin B1 underlies stem cell aging and impacts the homeostasis of adult neurogenesis and mood regulation.
A Bronchoscope Localization Method Using an Augmented Reality Co-Display of Real Bronchoscopy Images with a Virtual 3D Bronchial Tree Model

In recent years, Image-Guide Navigation Systems (IGNS) have become an important tool for various surgical operations. In the preparations for planning a surgical path, verifying the location of a lesion, etc., it is an essential tool; in operations such as bronchoscopy, which is the procedure for the inspection and retrieval of diagnostic samples for lung-related surgeries, it is even more so. The IGNS for bronchoscopy uses 2D-based images from a flexible bronchoscope to navigate through the bronchial airways in order to reach the targeted location. In this procedure, the accurate localization of the scope becomes very important, because incorrect information could potentially cause a surgeon to mistakenly direct the scope down the wrong passage. It would be a great aid for the surgeon to be able to visualize the bronchoscope images alongside the current location of the bronchoscope. For this purpose, in this paper, we propose a novel registration method to match real bronchoscopy images with virtual bronchoscope images from a 3D bronchial tree model built using computed tomography (CT) image stacks in order to obtain the current 3D position of the bronchoscope in the airways. This method is a combination of a novel position-tracking method using the current frames from the bronchoscope and the verification of the position of the real bronchoscope image against an image extracted from the 3D model using an adaptive-network-based fuzzy inference system (ANFIS)-based image matching method. Experimental results show that the proposed method performs better than the other methods used in the comparison.
Electrical Resistivity of High Purity Iron from 300 to 1300 °K

Electrical resistivity of high purity (99.99 + %) iron has been studied as a function of temperature from 300 to 1300 °K. It has been found that the resistivity decreases by about 2% going from α to γ iron. Such a large change has not been previously observed. The temperature dependence of the electrical resistivity of α and γ iron near the α γ transition is not the same as has been reported in older investigations. The resistivity at the Curie temperature does not exhibit a sharp anomaly but changes gradually with temperature. Der elektrische Widerstand von sehr reinem Eisen (99.99 + % Reinheit) ist in Abhangigkeit von der Temperatur im Bereich von 300 bis 1300 °K untersucht worden. Es wurde gefunden, das der Widerstand um 2% abnimmt, wenn man von α- zu γ-Eisen ubergeht. Eine so grose Veranderung wurde bisher noch nicht beobachtet. Die Temperaturabhangigkeit des elektrischen Widerstandes von α- und γ-Eisen in der Nahe des α γ-Uberganges stimmt mit alteren Messungen nicht uberein. Der Widerstand am Curie-Punkt zeigt keine Anomalie sondern andert sich allmahlich mit der Temperatur.
Effect of supplementation of wheat flour with resistant starch and monoglycerides in pasta dried at high temperatures

Summary Quality of pastas made from wheat flour (WF) and durum wheat semolina (DWS) with added resistant starch (RS) and distilled monoglyceride was evaluated through a central composite rotational design. A press extruder was used to produce the pasta. Water absorption index showed statistical difference between the WF and DWS indicating that proteins present in each samples were different. Pasta samples obtained with the WF presented a shorter cooking time and less solid loss than those obtained with DWS. Increase in volume and weight gain was similar for both samples. Instrumental texture responses showed that pasta made from DWS had higher values for firmness and springiness and lower for adhesiveness when compare to WF pastas. Nevertheless, pasta made from both samples showed similar behaviours of final RS contents of 4% after cooking. Therefore, they could be considered as a source of fibres according to the Brazilian Laws (3 g dietary fibre/100 g product).
Virulence role of the outer membrane protein CarO in carbapenem-resistant Acinetobacter baumannii

ABSTRACT Novel approaches to treat carbapenem-resistant Acinetobacter baumannii (CRAB) infections are urgently needed and anti-virulence drugs represent promising alternatives, but our knowledge on potential targets is scarce. We searched for potential A. baumannii virulence factors by whole-genome sequencing-based comparisons of CRAB clinical isolates causing bloodstream infections secondary to ventilator-associated pneumonia from demographics and clinically homogeneous patients, who received optimal treatment but with different clinical outcomes. Thus, the carO gene was interrupted in CRAB isolates from surviving patients, while it was intact in isolates from non-surviving patients, and proteomic/immunoblot techniques corroborated it. When the virulence role of A. baumannii CarO was analyzed in model systems, isogenic ΔcarO mutants and a CRAB clinical isolate with truncated CarO, showed lower ability to adhere and invade A549 cells and in vivo virulence. This unnoticed virulence role for CarO postulate this A. baumannii outer membrane protein as a potential target for new therapies against CRAB infections.
Modeling of the free radical polymerization of methylmethacrylate up to high temperature

Many models have been developed to describe the kinetics of the free radical polymn. of Me methacrylate (MMA). However, they are restricted to low temps. , e.g., below the glass transition temp. of the polymer, Tg. In this work, kinetics of bulk and soln. polymn. of MMA were detd. by differential scanning calorimetry (DSC) for temps. above Tg, i.e. 130-165 DegC. On the basis of our own exptl. results (high temps.) and those published in the literature (low temps.), it has been shown that with small modifications, the model of Achilias and Kiparissides gives a good description of kinetics for a temp. range from 20 to 165 DegC. Furthermore, all parameters appearing in the diffusion-limited part of the kinetic rate consts. have a clear phys. meaning and can be evaluated in terms of phys. and transport properties of the reacting species. [on SciFinder (R)]
Moringa oleifera Lam. extract rescues lead-induced oxidative stress, inflammation, and apoptosis in the rat cerebral cortex.

In this study, we investigate the potential protective effect of Moringa oleifera Lam. extract (MOE) against lead-induced neurotoxicity. Wistar rats were allocated equally into (a) a control group, (b) a lead acetate (PbAc) group intraperitoneally injected with 20 mg/kg PbAc, (c) a MOE group orally gavaged with MOE (250 mg/kg), and (d) a MOE + PbAc group orally gavaged with MOE 3 hr before receiving intraperitoneal injections of PbAc. All rats were treated for 14 days. Our results revealed that PbAc-induced brain injury, accompanied by increased levels of oxidative stress markers. Moreover, Pb enhanced the inflammatory response and triggered neuronal apoptosis, as well as significantly depleted glutathione content and inhibited antioxidant enzyme activity. Interestingly, concurrent treatment with MOE ameliorated oxidative stress, inflammation, and apoptosis in the brain cortex. The current study provides evidence that MOE has the potential to protect neuronal tissues in PbAc-exposed rats via attenuation of nuclear factor-kappa B (NF-κB) signaling. PRACTICAL APPLICATIONS: This study reports the potential neuroprotective effect of Moringa oleifera Lam. (MOE) against lead-induced cortical brain toxicity. Our data reveal that PbAc-induced oxidative stress, neuroinflammation, and apoptosis in cortical tissues. However, simultaneous treatment of rats with MOE abrogated cortical brain inflammatory biomarkers, mitigated cortical tissue damage, and restrained oxidative stress, programmed cell death, and nuclear factor-kappa B (NF-κB) translocation. In addition, MOE stimulated detoxifying enzymes in PbAc-treated rats. These findings provide evidence that simultaneous treatment with MOE has the potential to attenuate PbAc-induced brain damage in rats by restraining oxidative stress, neuroinflammation, and apoptosis via attenuation of NF-κB signaling.
Safety and efficacy of 3D-printed templates assisted CT-guided radioactive iodine-125 seed implantation for the treatment of recurrent cervical carcinoma after external beam radiotherapy

Objective To investigate the safety and efficacy of 3-dimensional (3D) printing non-coplanar templates (PNCT) assisted computer tomography (CT) guided radioactive 125I seed implantation (RISI) for the treatment of recurrent cervical carcinoma (RCC) after external beam radiotherapy (EBRT). Methods A total of 103 patients with inoperable post-EBRT RCC were included in this retrospective study. A total of 111 lesions received RISI. Eight lesions were at the pelvic center, 75 lesions were at the pelvic lateral, and 28 lesions were extra-pelvic metastasis. The median prescription dose was 120 Gy. The primary end points were adverse events and local control (LC), and the secondary end points were overall survival (OS) and progression-free survival. Results Grade 2 adverse events of acute nausea, diarrhea, and pollakiuria occurred in 1, 2, and 1 patient, respectively. One patient suffered from grade 3 acute proctitis. Late toxicity was observed in 2 patients with rectovaginal fistula. No grade 5 toxicity occurred. The 3-year LC and OS rates were 75.1% and 20.8%, respectively. The median OS was 17 months. The multivariate analysis showed that the minimum dose received by the “hottest” 90% of the gross tumor volume (D90) ≥130 Gy, squamous cell carcinoma, hemoglobin ≥80 g/L and good short-term efficacy (complete response or partial response) were independent predictors of LC and OS (all p<0.05). Conclusions 3D-PNCT assisted CT-guided RISI is a safe, effective, and minimally invasive modality for RCC. The hemoglobin level, pathological type, dose distribution and short-term efficacy are considered as independent factors for clinical outcomes.