Miracle-dz/UniFAR-FTUs huggingface dataset:
The prevalence of off-label use and supratherapeutic blood levels of outpatient psychotropic medication in suicidal adolescents

Introduction Adolescents with mental disorders show an increased risk of suicidal phenomena. Vice versa, suicidality is a serious adverse event of psychotropic drug therapy in adolescents. There are only a few new psychotropic agents approved for this young age group. We evaluated the (pre-pandemic) prevalence of off-label use as well as detailed blood concentrations of outpatient psychotropic medication and sex differences in a clinical population of suicidal adolescents. Methods The urine presence and serum levels of psychotropic substances of adolescents hospitalized due to their acute suicidality but without a known actual suicide attempt (i.e., no acute intoxication or serious self-injuries) were investigated routinely between 01.03. 2017 and 31.01. 2018. Urine (N = 205) and blood samples (N = 193) were taken at the beginning of closed inpatient admission, i.e., the results of the laboratory analysis reflect outpatient drug intake. The serum levels of psychopharmacological medication and OTC medication were measured. Results Our sample consists of 231 cases (boys: N = 54; girls: N = 177, ratio: 1:3.3), aged 12–17 years (average age: 15,4 years). The most prevalent psychiatric diagnoses were depressive episodes (54%) and adjustment disorders (25%), and girls were more often diagnosed with depressive disorders than boys (boy/girl ratio: 1:9.5, p < 0.0001). More than half of adolescents (56%) used at least one prescribed psychotropic drug at admission (24.8% ≥ two psychotropic drugs). Off-label use of second-generation antipsychotics was significantly more frequent than off-label use of antidepressants (85% vs. 31%, p < 0.01). Adolescents suffering from depressive disorders were significantly more often on-label treated than adolescents with neurotic or stress-related disorders (56% vs. 10%). Female cases with prescribed psychotropic drug use showed significantly more frequent supratherapeutic drug levels than male cases (5% vs. 27%, p < 0.05). Conclusion Female adolescents may have an increased risk of supratherapeutic blood levels, especially when outpatient prescribed psychotropic drugs are off-label used. Measurement of blood levels of outpatient-prescribed psychotropic drugs could be used to enhance the safety and efficacy of the individual psychopharmacological treatment of adolescent suicidal patients. There is an urgent need for more real-world evidence on the effective treatment of adolescents with psychotropic drugs.
Analysis of Psychological Well-Being in High Grade Elementary School Children

This research outlines an analysis of Psychological Well-Being in children who are in the final stages of primary school. The study used a literature review method with the aim of investigating and analysing a deeper understanding of aspects of psychological well-being in children of this age. Through analysing a number of literature sources, this study identified key factors that play a role in influencing psychological well-being in children in the late primary grades. These factors include, but are not limited to, social interactions at school, social support from family and peers, emotional development, adjustment skills and a supportive learning environment. The results of the analyzes suggest that psychological well-being in high school children is closely related to various psychosocial and environmental factors. Moreover, a better understanding of the relationship between these aspects and children's psychological well-being can provide valuable insights for educators, parents and mental health professionals in developing appropriate strategies and interventions to support positive psychological development in children at the primary school level. In conclusion, this study highlights the importance of a holistic understanding of the factors that influence psychological well-being in children in the upper primary grades. The implications of this study are expected to provide a foundation for the development of educational approaches and interventions aimed at improving the psychological well-being of children at this level.
Effect of Mussel Shells as Soil pH Amendment on the Growth and Productivity of Rosemary (Rosmarinus officinalis L.) Cultivation

Mussel shells, with their calcium carbonate content, serve as a natural pH buffer, aiding in neutralizing acidic soils and, consequently, enhancing nutrient availability for plants. The aim of this study was to evaluate the effect of treating soils with mussel shells as a soil pH amendment on the agronomic characteristics and productivity of Rosmarinus officinalis. A pot experiment was set up for two growing years. The treatments were amended using different doses of mussel shells. Overall, the treatments were the following: C: unamended soil (control); T1: 0.1%; T2: 0.3%; T3: 0.5%; T4: 1%; T5: 3%; T6: 6%. Plant height was higher in pots amended with 6% mussel shells and reached the value of 32.2 cm in the first year and 51 cm in the second. The application of mussel shells increased the branch length by 53.4–58.7% and the number of branches per plant by 61.3–62% in T6 compared to the control. The total yield of fresh and dry weight in the 1st and 2nd year was ordered as follows: T6 > T5 > T4 > T3 > T2 > T1 > C. In conclusion, while the established optimal quantity for neutralizing soil pH is 300 g of mussel shells per 10 kg of soil, it has been observed that a ratio of 600 g of mussel shells proves more effective in terms of both the productivity and agronomic characteristics of rosemary.
Precipitation Identification with Bispectral Satellite Information Using Deep Learning Approaches

AbstractIn the development of a satellite-based precipitation product, two important aspects are sufficient precipitation information in the satellite-input data and proper methodologies, which are used to extract such information and connect it to precipitation estimates. In this study, the effectiveness of the state-of-the-art deep learning (DL) approaches to extract useful features from bispectral satellite information, infrared (IR), and water vapor (WV) channels, and to produce rain/no-rain (R/NR) detection is explored. To verify the methodologies, two models are designed and evaluated: the first model, referred to as the DL-IR only method, applies deep learning approaches to the IR data only; the second model, referred to as the DL-IR+WV method, incorporates WV data to further improve the precipitation identification performance. The radar stage IV data are the reference data used as ground observation. The operational product, Precipitation Estimation from Remotely Sensed Information Using Artifici.
Analysis of Income and Transaction Costs of Purchasing Farmer’s Sugarcane at Wonolangan Sugar Factory, Probolinggo Regency, East Java

Sugarcane is the main raw material for making sugar in Indonesia. Wonolangan Sugar Factory is one of the sugar processing factories located in Probolinggo Regency. PG (Pabrik Gula) Wonolangan Sugar Factory as buys sugarcane using Weight Sugarcane Buying System (SPT-ST) and a Potential system (SPT-SP). The difference in the sugarcane purchasing system is expected to provide different income to farmers, therefore the purpose of this study is to determine the income level of farmers in the SPT-ST and SPT-SP system; fine out the cost of economic transactions in the SPT-ST and SPT-SP system. This research method uses analytical methods with transaction cost analysis and independent t-test analysis, as well as quantitative methods with income analysis. The results showed: (1) Average income of farmers in the SPT-ST is Rp. 32,810,020.87/Ha, and Rp. 30,625,224.50/Ha for farmers with the SPT-SP sales system; (2) The transaction costs for farmers in the sugarcane buying system (SPT-ST) are Rp. 271,310/season and Rp. 679,583/season for SPT-SP farmers. The proportion of transaction costs to the income of SPT-SP farmers is 2.3%, while for SPT-ST farmers it is 0.8%. The proportion of transaction costs to the total costs incurred by SPT-ST farmers was 0.7%, for SPT- SP farmers it was 1.7%; (3) There is no significant difference between the average income of farmers with the SPT-ST and SPT-SP sales system in the PG Wonolangan. The difference in the average income is Rp. 2,157,776.06/Ha.
The influence of social media promotion, word of mouth, and quality service on repurchase intention: The role of trust

The coffee business or coffee shop is a sector that is growing rapidly. Coffee shops have evolved into more comfortable and modern places, caused by changes in people's lifestyles and behavior in consuming products and services. This situation also brings tight competition in the coffee shop business, where they must make several efforts to keep their brand selected. Some actions are maximizing social media promotion channels, word of mouth (WOM), and increasing service quality, which are expected to increase trust so that consumer repurchase intention can increase indirectly. This research aims to determine the influence of social media promotion, WOM, and service quality on consumer repurchase intention, both directly and through trust mediation. They are using a population of coffee shop consumers in Surakarta. We take a sample of 200 respondents. This number was obtained from an online survey via the Google Forms platform. The questionnaire results were analyzed using the partial least squares method with the SmartPLS 3.0 software application. The research results reveal that social media promotion, WOM, and quality service directly impact repurchase intention. Meanwhile, indirectly, namely through the mediation of trust, only WOM and quality service significantly affect consumers' intention to repurchase. These results imply that when deciding to repurchase, consumers look at the quality of the product they purchased and pay attention to other things. Therefore, managers or owners need to pay more attention to these details.
Comparison of climate time series – Part 5: Multivariate annual cycles

Abstract. This paper develops a method for determining whether two vector time series originate from a common stochastic process. The stochastic process considered incorporates both serial correlations and multivariate annual cycles. Specifically, the process is modeled as a vector autoregressive model with periodic forcing, referred to as a VARX model (where X stands for exogenous variables). The hypothesis that two VARX models share the same parameters is tested using the likelihood ratio method. The resulting test can be further decomposed into a series of tests to assess whether disparities in the VARX models stem from differences in noise parameters, autoregressive parameters, or annual cycle parameters. A comprehensive procedure for compressing discrepancies between VARX models into a minimal number of components is developed based on discriminant analysis. Using this method, the realism of climate model simulations of monthly mean North Atlantic sea surface temperatures is assessed. As expected, different simulations from the same climate model cannot be distinguished stochastically. Similarly, observations from different periods cannot be distinguished. However, every climate model differs stochastically from observations. Furthermore, each climate model differs stochastically from every other model, except when they originate from the same center. In essence, each climate model possesses a distinct fingerprint that sets it apart stochastically from both observations and models developed by other research centers. The primary factor contributing to these differences is the difference in annual cycles. The difference in annual cycles is often dominated by a single component, which can be extracted and illustrated using discriminant analysis.
The Influence Of Reverification Service Quality On Sellers Satisfaction In Lumajang Pasirian Traditional Market

This research aims to determine the influence of reverification service quality consisting of tangibles, reliability, responsiveness, assurance, and empathy on the seller satisfaction in Pasirian Traditional Market with a descriptive quantitative approach. The data used was obtained from 145 questionnaires distributed to sellers who use measuring instrument in their transactions. Previously, the questionnaire had been tested for validity and reliability. The data processing method uses multiple linear regression analysis by SPSS 25 analysis tool. The results show that partially only tangibles, responsiveness, assurance and empathy have an influence on seller satisfaction. Further test results show that the reverification service quality consisting of tangibles, reliability, responsiveness, assurance, and empathy simultaneously affect the seller satisfaction at the Pasirian Traditional Market.
Intestinal Inflammation and Regeneration–Interdigitating Processes Controlled by Dietary Lipids in Inflammatory Bowel Disease

Inflammatory bowel disease (IBD), including Crohn’s disease and ulcerative colitis, is a disease of chronic inflammatory conditions of the intestinal tract due to disturbance of the inflammation and immune system. Symptoms of IBD include abdominal pain, diarrhea, bleeding, reduced weight, and fatigue. In IBD, the immune system attacks the intestinal tract’s inner wall, causing chronic inflammation and tissue damage. In particular, interlukin-6 and interlukin-17 act on immune cells, including T cells and macrophages, to amplify the immune responses so that tissue damage and morphological changes occur. Of note, excessive calorie intake and obesity also affect the immune system due to inflammation caused by lipotoxicity and changes in lipids supply. Similarly, individuals with IBD have alterations in liver function after sustained high-fat diet feeding. In addition, excess dietary fat intake, along with alterations in primary and secondary bile acids in the colon, can affect the onset and progression of IBD because inflammatory cytokines contribute to insulin resistance; the factors include the release of inflammatory cytokines, oxidative stress, and changes in intestinal microflora, which may also contribute to disease progression. However, interfering with de novo fatty acid synthase by deleting the enzyme acetyl-CoA-carboxylase 1 in intestinal epithelial cells (IEC) leads to the deficiency of epithelial crypt structures and tissue regeneration, which seems to be due to Lgr5+ intestinal stem cell function. Thus, conflicting reports exist regarding high-fat diet effects on IBD animal models. This review will focus on the pathological basis of the link between dietary lipids intake and IBD and will cover the currently available pharmacological approaches.
Comparative Evaluation of Single Rotary File System and Sequential Multi-file Rotary Systems on Time for Biomechanical Preparation and Obturation Quality in Single-visit Pulpectomy Protocol: A Double-blind Randomized Clinical Trial

Abstract Background Single-visit pulpectomy (SVP) protocol with rotary files is highly recommended for the treatment of teeth with irreversible pulpitis. Various rotary endodontic files specially designed for use in the pediatric population are available. The aim is to clinically assess the parameters related to the time required for biomechanical preparation (TBMP) and quality of filling using a single file system vs a sequential multi-file system in infected primary mandibular molars. Materials and methods A total of 45 infected primary molars were allocated to three groups (two experimental groups (n = 15) and a control group. The first experimental group was instrumented using NiTi K-Flex files, the second group with a single file rotary system with variably variable (VV) taper, and the third with a sequential multi-file system with constant taper. Biomechanical preparation time was recorded and standardized digital radiograph (RVG) were taken pre- and postinstrumentation. The data recorded was sent for statistical analysis. Conclusion There is a substantial reduction of TBMP in primary molars using single file VV taper and multi-sequential file constant taper. Obturation time for all three file systems was comparable and there were no differences between the three file systems used (p > 0.05). Multi-sequential file constant taper files showed a higher probability of optimal obturations and minimal voids followed by NiTi “K-Flex” files and single file system but the difference was nonsignificant (p > 0.05). However, using a rotary in primary teeth results in better canal shape, and less TBMP leading to a better quality of treatment in less time. How to cite this article Shetty B, Singh R, Patil V, et al. Comparative Evaluation of Single Rotary File System and Sequential Multi-file Rotary Systems on Time for Biomechanical Preparation and Obturation Quality in Single-visit Pulpectomy Protocol: A Double-blind Randomized Clinical Trial. Int J Clin Pediatr Dent 2023;16(S-3):S247–S252.
Optimal Position Design for Unmanned Aerial Vehicle Relay-Assisted Covert Communication Based on Active Countermeasures

Covert communication is one of the most promising ways in 6G due to its high concealment, diverse forms, and strong compatibility. In traditional covert communication, high-gain antennas, signal amplifiers, and multipath transmission methods are commonly used to expand communication distance. However, the current research on covert communication is mostly limited to fixed receivers or fixed detection parties. In order to solve the above problems, we propose a covert communication countermeasure model in which the maximum covert transmission rate is achieved by introducing the unmanned aerial vehicle (UAV) as a typical high-flexibility relay under a movable detection party. Specifically, we obtain the optimal detection threshold and its corresponding total error probability through binary hypothesis testing and the monotonicity of the function at first. Then, we derive the optimal expressions for the covert constraint and transmission outage constraint in our model under the optimal detection threshold and total error probability. In addition, we optimize the position of the UAV based on the covert constraint and transmission outage through the Lagrange multiplier method. The numerical results reinforce the validity of our proposed approach and showcase the enhanced performance of the covert transmission rate.
World Journal of Psychiatry

BACKGROUND Several studies have reported that the walking trail making test (WTMT) completion time is significantly higher in patients with developmental coordination disorders and mild cognitive impairments. We hypothesized that WTMT performance would be altered in older adults with white matter hyperintensities (WMH). AIM To explore the performance in the WTMT in older people with WMH.
Infectious Aortitis with Abdominal Aortic Aneurysm in a 47-Year-Old Female with Systemic Lupus Erythematosus

Aortic aneurysms are not commonly reported among patients with systemic lupus erythematosus (SLE). We report a case of a 47-year-old Filipino female diagnosed with SLE 17 years ago maintained on prolonged oral steroids, azathioprine, and hydroxychloroquine. She also had lupus nephritis, secondary hypertension, and dyslipidemia. She initially presented with a week-long watery nonbloody diarrhea with associated diffuse crampy abdominal pain and generalized weakness. She was admitted for a week at a provincial hospital and was given an unrecalled antibiotic with resolution of symptoms. Upon discharge, however, she experienced two weeks of severe right lower quadrant pain radiating to the back and left lower quadrant, with no history of diarrhea, vomiting, dysuria, and fever. Complete blood count showed slight leukocytosis and elevated C-reactive protein. Abdominal imaging revealed a saccular infrarenal aneurysm with dissection. An atherosclerotic mechanism was primarily considered, but a vasculitic process was likewise considered due to elevated acute phase reactants. The initial plan was Endovascular Aneurysm Repair (EVAR) but due to financial limitations, an exploratory laparotomy with infrarenal endoaneurysmorrhaphy was eventually performed. Intraoperative findings were a saccular infrarenal aneurysm with dissection up to the proximal right common iliac artery and an abscess compartment within the false lumen in the anterior aortic wall. Abscess culture yielded high growth of Salmonella group B. Micrographs of the aortic wall biopsy showed fibrin deposition necrosis and calcification with peripheral viable cellular infiltrates consisting of neutrophils and foamy macrophages. Inadvertently placing an endovascular graft in an infected aortic aneurysm would have led to graft infection and catastrophic morbidity. We highlight the significance of having a high index of suspicion for infectious causes of aortitis among immunocompromised patients presenting with aneurysm prior to pursuing an endovascular versus an open approach for repair.
The Development and Characterisation of a P(3HB-co-4HB)–Bioactive Glass–Graphene Hydrogel as a Potential Formulation for Biomedical and Therapeutical Translation

The clinical management of wounds is known to be a significant challenge: not only does the dressing need to ensure and provide the appropriate barrier and healing characteristics, but consideration of patient compliance concerning comfort, functionality, and practicality also needs to be included. The poly(3-hydroxybutyrate-co-4-hydroxubutyrate) (P(3HB-co-4HB)) copolymer, isolated from Cupriavidus malaysiensis USM1020 (C. malaysiensis USM1020), was produced in the presence of excess carbon sources (1,4-butanediol and 1,6-hexanediol) using either a shake flask cultivation process or a bioreactor fermentation system. P(3HB-co-4HB) is widely known to be biodegradable and highly biocompatible and contains a tuneable 4HB monomer molar fraction, which is known to affect the final physicochemical properties of the intracellular copolymer. In this paper, we describe not only the fabrication of the polymeric gel but also its optimised profiling using a range of physical and mechanical techniques, i.e., SEM, FTIR, DMA, DSC, and WCA. The further enhancement of the gel through additional functionalisation with sol-gel-derived bioactive glass and liquid-exfoliated graphene was also investigated. The biocompatibility and biological characterisation of the substrates was assessed using murine osteoblasts (MC3T3), human primary dermal fibroblasts (HDFs), human fibroblast (BJ) cells, and standard cell culture assays (i.e., metabolic activity, LDH release, and live/dead staining). In short, P(3HB-co-4HB) was successfully isolated from the bacteria, with the defined physico-chemical profiles dependent on the culture substrate and culturing platform used. The additional enhancement of the copolymer with bioactive glass and/or graphene was also demonstrated by varying the combination loading of the materials, i.e., graphene resulted in an increase in tensile strength (~11 MPa) and the wettability increased following the incorporation of bioactive glass and 0.01 wt% graphene (WCA ~46.3°). No detrimental effects in terms of biocompatibility were noticed during the 7 days of culture in the primary and established cell lines. This study demonstrates the importance of optimising each of the individual components within the biocomposite and their relationship concerning the fine-tuning of the material’s properties, thus targeting and impacting the endpoint application.