Miracle-dz/UniFAR-FTUs huggingface dataset:
Long COVID-19 Syndrome Severity According to Sex, Time from the Onset of the Disease, and Exercise Capacity—The Results of a Cross-Sectional Study

Symptoms of long COVID-19 syndrome (long COVID-19) are reported by 80% of convalescents up to several months after contracting the coronavirus-19 disease (COVID-19). The study aimed to assess the frequency and correlations of long COVID symptoms with sex, disease severity, time since the onset of the disease, and exercise capacity in a population of Polish convalescents hospitalized as a part of a rehabilitation program after COVID-19. The retrospective analysis was carried out based on medical records concerning reported symptoms, comorbidities, exercise capacity, fatigue and dyspnea on Borg’s scale, arterial oxygen saturation (SpO2), spirometric parameters, chest X-rays/computed tomography scans, systolic pulmonary artery pressure, and left ventricular ejection fraction. The study involved 471 patients aged 63.83 ± 9.93 years who had been hospitalized 191.32 ± 75.69 days from the onset of COVID-19, of which 269 (57.1%) were women. The most common symptoms were fatigue (99.57%), dyspnea (99.36%), and myalgia (97.03%). Women reported more symptoms than men (p < 0.001) and rated their fatigue as more severe (p = 0.021). Patients with depressed moods reported more physical symptoms than others (p < 0.001). Most long COVID symptoms, including dyspnea, fatigue, and depressive symptoms, were found with the same frequency in patients 12–24 weeks and >24 weeks after recovery (p = 0.874, p = 0.400, and p = 0.320, respectively), regardless of acute COVID-19 severity (p = 0.240, p = 0.826, and p = 0.108, respectively). Dyspnea severity correlated with forced vital capacity (FVC) (r = −0.153, p = 0.005), and forced expiratory volume in one second (FEV1) (r = −0.142, p = 0.008). Fatigue severity correlated with impaired FVC and FEV1 (both r = −0.162, p = 0.003). Fatigue and dyspnea inversely correlated with the distance in a six-minute walk test (r = −0.497, p < 0.001, and r = −0.327, p < 0.001). In conclusion, in our cohort, long COVID symptoms are more common in women. Dyspnea/fatigue and depressive symptoms do not tend to subside after an average six-month recovery period. The intensity of perceived fatigue may be exaggerated by the coexistence of neuropsychiatric disorders. Increased fatigue and dyspnea correlate with impaired spirometric parameters and significantly affects convalescents’ exercise capacity.
Physics of outflows near solar active regions

Abstract. Hinode/EIS observations have revealed outflows near active regions which remain unexplained. An outflow region observed by the EUV Imaging Spectrometer (EIS) that appears slightly redshifted at low temperatures and blueshifted at higher temperatures is presented. We conduct simulations and use those to create synthetic line profiles in order to replicate the observed line profiles of an apparent open structure. The results of the forward modelling support a scenario whereby long loops consisting of multiple strands undergo a cyclical process of heating and cooling on timescales of approximately 80 min.
The rhetorical density of authorial emotiveness and voice passiveness in abstract compositions

The study sought to examine authorial emotiveness and passive tone of academic writing in academic research abstracts (RAs) to appeal to the Aristotelian pathos. Based on the integrated framework of Contrastive Rhetoric and Domain of Emotional Tone, this study investigated the overall demonstration of emotional appeal through quantitative content analysis of two rhetorical items - emotive phrases and passive voice in subtly ‘colouring’ the academic tone of research abstracts. Four hundred eighty (480) research abstracts (RAs) of the international non-native English writers (INE) and Malaysian non-native English writers (MNNE) were sampled from 88 national and international indexed journals. Two quantitative analysis tools were used to auto-generate the frequency percentages, which were then analysed with SPSS. It was found that MNNE RAs showed a significantly denser level of overall emotional appeal than INE RAs. The authorial tones of emotiveness and passiveness were also distinctly heavier in academic MNNE RAs than INE RAs. These were concluded as the marked rhetorical features of non-native English writers, deflecting them from the ones used by native English writers. In terms of research implication, the common trend of these features was not to be misconstrued by MNNE writers as the main rhetorical appeal of research composition.
Multiphase averaging and the inverse spectral solution of the Korteweg—de Vries equation

Inverse spectral theory is used to prescribe and study equations for the slow modulations of N-phase wave trains for the Korteweg-de Vries (KdV) equation. An invariant representation of the modulational equations is deduced. This representation depends upon certain differentials on a Riemann surface. When evaluated near ∞ on the surface, the invariant representation reduces to averaged conservations laws; when evaluated near the branch points, the representation shows that the simple eigenvalues provide Riemann invariants for the modulational equations. Integrals of the invariant representation over certain cycles on the Riemann surface yield “conservation of waves. ” Explicit formulas for the characteristic speeds of the modulational equations are derived. These results generalize known results for a single-phase traveling wave, and indicate that complete integrability can induce enough structure into the modulational equations to diagonalize (in the sense of Riemann invariants) their first-order terms.
Similarity solutions of the generalized Korteweg–de Vries equation

Numerical simulations and group invariance considerations point to the existence of similarity solutions of the form formula here of the generalized Korteweg–de Vries equation formula here Here, x∗, t∗ and c are real parameters, x and t are real variables with t≠t∗, p is a positive integer and interest is focussed on the case where p[ges ]4 for which solutions of the initial-value problem for (**) are not known to be always globally defined. It is shown that smooth solutions of (**) of the form appearing in (*) do indeed exist. Some detailed properties of the function ψ appearing in (*) are also obtained.
Band filling in GaAs/AlGaAs multiquantum well lasers and its effect on the threshold current

Existing theoretical models for multi-quantum-well laser operation are not always accurate in evaluating band-filling characteristics. This, as a result of the partial omission of some significant physical processes or simplified modeling, sometimes leads to excessively optimistic prediction of threshold-current reduction in these types of lasers. An improved model which includes the effects of band nonparabolicity, revised band offsets at the heterojunction interface, nonradiative processes in the barrier and waveguide regions, and the energy-dependent spectral linewidth has been developed. It is tested satisfactorily by comparing its numerical prediction to the experimental results on cavity-length dependence of threshold current for lasers with a different number of quantum wells. >
Aging and Mixed Emotions: A Word-Suffix Approach in Free Recall

The current study investigated mixed-emotional memories in groups of young, young-old, and old-old participants. We used a “word-suffix approach” to simulate the co-occurrence of positive and negative emotions. The participants engaged in a free-recall task for valenced words and mixed-emotional words (valenced words coupled with pejorative or endearment suffixes). Our results showed that the groups of older adults recalled higher numbers of suffixed words compared to their younger counterparts. Our findings highlighted older adults’ tendency to perceive and remember emotionally ambivalent words to a greater extent than younger adults and showed that the young-old participants were particularly good at solving ambivalence by focusing on positive-dominant ambivalent words.
Economic Evaluation of Direct Oral Anticoagulants Compared to Warfarin for Venous Thromboembolism in Thailand: A Cost-Utility Analysis

Background: Direct oral anticoagulants (DOACs) have been used for venous thromboembolism (VTE) in Thailand. However, they have not been listed in the National List of Essential Medicines (NLEM). A cost-effectiveness analysis is needed to aid policymakers in deciding whether DOACs should be listed in the NLEM. This study aimed to assess the cost-effectiveness of DOACs for patients with VTE in Thailand. Methods: A cohort-based state transition model was constructed from a societal perspective with a lifetime horizon. All available DOACs, including apixaban, rivaroxaban, edoxaban, and dabigatran, were compared with warfarin. A 6-month cycle length was used to capture all costs and health outcomes. The model consisted of nine health states, including VTE on treatment, VTE off treatment, recurrent VTE, clinically relevant non-major bleeding, gastrointestinal bleeding, intracranial bleeding, post-intracranial bleeding, chronic thromboembolic pulmonary hypertension, and death. All inputs were based on a comprehensive literature review. The model outcomes included total cost and quality-adjusted life-years (QALYs) with a 3% annual discount rate. A fully incremental cost-effectiveness analysis and the incremental cost-effectiveness ratio (ICER) per QALY gained were calculated at a willingness-to-pay (WTP) of THB 160,000/QALY ($5003). The robustness of the findings was assessed using deterministic and probabilistic sensitivity analyses. Results: All DOACs were associated with a decreased risk of VTE recurrence and intracranial hemorrhage. In the base-case analysis, apixaban could increase 0.16 QALYs compared with warfarin. An ICER for apixaban was 269,809 Thai baht (THB)/QALY ($8437/QALY). Rivaroxaban had a better QALY than warfarin at 0.09 QALYs with an ICER of 757,363 THB/QALY ($23,682/QALY). Edoxaban and dabigatran could also increase by 0.10 QALYs with an ICER of 709,945 THB ($22,200) and 707,145 THB ($22,122)/QALY, respectively. Our probabilistic sensitivity analyses indicated that warfarin had a 99.8% possibility of being cost-effective, while apixaban had a 0.2% possibility of being cost-effective at the current WTP. Other DOACs had no possibility of being cost-effective. Conclusions: All DOACs were not cost-effective for VTE treatment at the current WTP in Thailand. Apixaban is likely to be the best option among DOACs.
Comprehensive Metabolite Profiling of Berdav Propolis Using LC-MS/MS: Determination of Antioxidant, Anticholinergic, Antiglaucoma, and Antidiabetic Effects

Propolis is a complex natural compound that honeybees obtain from plants and contributes to hive safety. It is rich in phenolic and flavonoid compounds, which contain antioxidant, antimicrobial, and anticancer properties. In this study, the chemical composition and antioxidant activities of propolis were investigated; ABTS•+, DPPH• and DMPD•+ were prepared using radical scavenging antioxidant methods. The phenolic and flavonoid contents of propolis were 53 mg of gallic acid equivalent (GAE)/g and 170.164 mg of quercetin equivalent (QE)/g, respectively. The ferric ion (Fe3+) reduction, CUPRAC and FRAP reduction capacities were also studied. The antioxidant and reducing capacities of propolis were compared with those of butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT), α-tocopherol and Trolox reference standards. The half maximal inhibition concentration (IC50) values of propolis for ABTS•+, DPPH• and DMPD•+ scavenging activities were found to be 8.15, 20.55 and 86.64 μg/mL, respectively. Propolis extract demonstrated IC50 values of 3.7, 3.4 and 19.6 μg/mL against α-glycosidase, acetylcholinesterase (AChE) and carbonic anhydrase II (hCA II) enzyme, respectively. These enzymes’ inhibition was associated with diabetes, Alzheimer’s disease (AD) and glaucoma. The reducing power, antioxidant activity and enzyme inhibition capacity of propolis extract were comparable to those demonstrated by the standards. Twenty-eight phenolic compounds, including acacetin, caffeic acid, p-coumaric acid, naringenin, chrysin, quinic acid, quercetin, and ferulic acid, were determined by LC-MS/MS to be major organic compounds in propolis. The polyphenolic antioxidant-rich content of the ethanol extract of propolis appears to be a natural product that can be used in the treatment of diabetes, AD, glaucoma, epilepsy, and cancerous diseases.
Composite contour generation for Beta-spline surface reconstruction

Branching is a process of connecting two adjacent contours called base and branch contours where the numbers of sub contours for each of both contours are different. All points between the contours have to be correctly paired to avoid a twisting surface. In contours connection, continuity is an issue to ensure the surface fit to the required smoothness. Therefore, two main steps to be focused in surface reconstructions are branching technique and surface continuity. This study used composite contour generation as the branching technique which generates an intermediate contour as combination of modified base and branch contours. Although the inserted new contour will disturb the position of original contours, the continuity can be preserved if the fitted surface is Beta-spline. Beta-spline is built with G2 continuity condition, and the changes of the data points position will not affect the continuity. Hence, surface fitting using Beta-spline will simplify the reconstruction process. The result shows sever.
Three-Dimensional Evaluation of the Cytotoxicity and Antibacterial Properties of Alpha Lipoic Acid-Capped Silver Nanoparticle Constructs for Oral Applications

There is a need to develop bifunctional scaffolds that provide antibacterial protection while encouraging host cell attachment/proliferation. This study evaluates HyStem®-C, and photo-cross-linked GelMA hydrogels for encapsulation and stabilisation of silver nanoparticles (AgNPs). We studied the behaviour of AgNPs and matrix interactions within both hydrogel systems. The cell viability of encapsulated human gingival fibroblasts (HGFs) was determined by Prestoblue® assay and live/dead staining. The release of AgNPs was monitored by inductively coupled plasma–mass spectroscopy. The antibacterial properties of the GelMA-AgNP constructs were determined using disc diffusion. Even distribution of AgNPs in GelMA induced a significant decrease in cell viability (p < 0.0001), whereas AgNP aggregates did not induce cytotoxicity in HyStem®-C. AgNPs doses ≥ 0.5 µg/mL in GelMA were significantly toxic to the HGFs (p < 0.0001). The release of AgNPs from GelMA after 48 h was 20% w/w for 0.1 µg/mL and 51% for 100 µg/mL of AgNPs. At ≥5 µg/mL, a significant intra-construct bactericidal effect was observed. The disc diffusion assay shows that GelMA-incorporated AgNPs were found to be effective against both Escherichia coli and Staphylococcus aureus at 50 and 100 µg/mL, respectively. Visible photo-cross-linked GelMA stably incorporated AgNPs to provide an antimicrobial regenerative construct for oral applications.
How Nanoparticles Modify Adsorbed Proteins: Impact of Silica Nanoparticles on the Hemoglobin Active Site

The adsorption of proteins on surfaces has been studied for a long time, but the relationship between the structural and functional properties of the adsorbed protein and the adsorption mechanism remains unclear. Using hemoglobin adsorbed on silica nanoparticles, we have previously shown that hemoglobin’s affinity towards oxygen increases with adsorption. Nevertheless, it was also shown that there were no significant changes in the quaternary and secondary structures. In order to understand the change in activity, we decided in this work to focus on the active sites of hemoglobin, the heme and its iron. After measuring adsorption isotherms of porcine hemoglobin on Ludox silica nanoparticles, we analyzed the structural modifications of adsorbed hemoglobin by X-ray absorption spectroscopy and circular dichroism spectra in the Soret region. It was found that upon adsorption, there were modifications in the heme pocket environment due to changes in the angles of the heme vinyl functions. These alterations can explain the greater affinity observed.
HPV and Cervical Cancer: A Review of Epidemiology and Screening Uptake in the UK

Cervical cancer is the fourth most common malignancy in females worldwide, and a leading cause of death in the United Kingdom (UK). The human papillomavirus (HPV) is the strongest risk factor for developing cervical intraepithelial neoplasia and cancer. Across the UK, the national HPV immunisation programme, introduced in 2008, has been successful in protecting against HPV-related infections. Furthermore, the National Health Service (NHS) implemented the cytology-based cervical cancer screening service to all females aged 25 to 64, which has observed a decline in cervical cancer incidence. In the UK, there has been an overall decline in age-appropriate coverage since April 2010. In 2019, the COVID-19 pandemic disrupted NHS cancer screening and immunisation programmes, leading to a 6.8% decreased uptake of cervical cancer screening from the previous year. Engagement with screening has also been associated with social deprivation. In England, incidence rates of cervical cancer were reported to be 65% higher in the most deprived areas compared to the least, with lifestyle factors such as cigarette consumption contributing to 21% of cervical cancer cases. In this article, we provide an update on the epidemiology of cervical cancer, and HPV pathogenesis and transmission, along with the current prevention programmes within the NHS.
Development of Insulating Masonry Bricks from Wood Fiber and Varying Milled Glass Proportion

Thermal efficient sandcrete bricks are masonry units with good thermal insulating properties. Wood fiber (WF) possesses low thermal conductivity, hence, its incorporation in mortar mix results in thermal efficient masonry units. Milled glass (MG) could be added for strength enhancement. This study incorporated WF into mortar mix at a constant dosage of 5 wt. %, with varying MG proportions of 0, 5, 10, 15 and 20 wt. % and cured for 7, 14 and 28 days. The results obtained showed minimization of porosity and water absorption at increasing MG content. Density and compressive strength were enhanced as MG content increased. Flexural and splitting tensile strengths appreciated and peaked at 15 wt. % MG. Thermal performance measured demonstrated progressive appreciation in thermal conductivity while specific heat capacity followed a downtrend as MG dosage increased. The study revealed that the collage of 5 wt. % wood fiber and 15 wt. % MG yielded optimum result. The study, therefore, concludes that the addition of milled glass and wood fiber positively and significantly affected the properties of sandcrete bricks. 15 wt. % of milled glass and 5% wood fiber inclusion in sandcrete bricks are recommended for use by construction practitioners.
Unravelling concurring degradation mechanisms in InGaAlP light-emitting diode structures by optical overstress experiments under reverse bias

We examine the influence of an applied reverse bias on the optically induced and measured photoluminescence degradation characteristics of an InGaAlP light-emitting diode (LED) structure. We show that a reverse bias applied simultaneously to laser excitation of the sample has a strong impact on the observable photoluminescence degradation properties of the structure investigated via intense laser excitation. With the help of this approach, it is possible to control the carrier density and the internal electric field of the diode independently. By doing this, a distinction of several usually interfering photoluminescence degradation mechanisms from each other is achievable. Further, a comparison of the experimental data with simulated data delivers some indication on the local origin of the defect evolution processes within the light-emitting diode structure.
Efficacy Validation of SARS-CoV-2-Inactivation and Viral Genome Stability in Saliva by a Guanidine Hydrochloride and Surfactant-Based Virus Lysis/Transport Buffer

To enhance biosafety and reliability in SARS-CoV-2 molecular diagnosis, virus lysis/transport buffers should inactivate the virus and preserve viral RNA under various conditions. Herein, we evaluated the SARS-CoV-2-inactivating activity of guanidine hydrochloride (GuHCl)- and surfactant (hexadecyltrimethylammonium chloride (Hexa-DTMC))-based buffer, Prep Buffer A, (Precision System Science Co., Ltd., Matsudo, Japan) and its efficacy in maintaining the stability of viral RNA at different temperatures using the traditional real-time one-step RT-PCR and geneLEAD VIII sample-to-result platform. Although Prep Buffer A successfully inactivated SARS-CoV-2 in solutions with high and low organic substance loading, there was considerable viral genome degradation at 35 °C compared with that at 4 °C. The individual roles of GuHCl and Hexa-DTMC in virus inactivation and virus genome stability at 35 °C were clarified. Hexa-DTMC alone (0.384%), but not 1.5 M GuHCl alone, exhibited considerable virucidal activity, suggesting that it was essential for potently inactivating SARS-CoV-2 using Prep Buffer A. GuHCl and Hexa-DTMC individually reduced the viral copy numbers to the same degree as Prep Buffer A. Although both components inhibited RNase activity, Hexa-DTMC, but not GuHCl, directly destroyed naked viral RNA. Our findings suggest that samples collected in Prep Buffer A should be stored at 4 °C when RT-PCR will not be performed for several days.
Advanced Skin Antisepsis: Application of UVA-Cleavable Hydroxyethyl Starch Nanocapsules for Improved Eradication of Hair Follicle-Associated Microorganisms

Hair follicles constitute important drug delivery targets for skin antisepsis since they contain ≈25% of the skin microbiome. Nanoparticles are known to penetrate deeply into hair follicles. By massaging the skin, the follicular penetration process is enhanced based on a ratchet effect. Subsequently, an intrafollicular drug release can be initiated by various trigger mechanisms. Here, we present novel ultraviolet A (UVA)-responsive nanocapsules (NCs) with a size between 400 and 600 nm containing hydroxyethyl starch (HES) functionalized by an o-nitrobenzyl linker. A phase transfer into phosphate-buffered saline (PBS) and ethanol was carried out, during which an aggregation of the particles was observed by means of dynamic light scattering (DLS). The highest stabilization for the target medium ethanol as well as UVA-dependent release of ethanol from the HES-NCs was achieved by adding 0.1% betaine monohydrate. Furthermore, sufficient cytocompatibility of the HES-NCs was demonstrated. On ex vivo porcine ear skin, a strong UVA-induced release of the model drug sulforhodamine 101 (SR101) could be demonstrated after application of the NCs in cyclohexane using laser scanning microscopy. In a final experiment, a microbial reduction comparable to that of an ethanol control was demonstrated on ex vivo porcine ear skin using a novel UVA-LED lamp for triggering the release of ethanol from HES-NCs. Our study provides first indications that an advanced skin antisepsis based on the eradication of intrafollicular microorganisms could be achieved by the topical application of UVA-responsive NCs.