Miracle-dz/UniFAR-FTUs huggingface dataset:
Inflammation in Myocardial Ischemia/Reperfusion Injury: Underlying Mechanisms and Therapeutic Potential

Acute myocardial infarction (MI) occurs when blood flow to the myocardium is restricted, leading to cardiac damage and massive loss of viable cardiomyocytes. Timely restoration of coronary flow is considered the gold standard treatment for MI patients and limits infarct size; however, this intervention, known as reperfusion, initiates a complex pathological process that somewhat paradoxically also contributes to cardiac injury. Despite being a sterile environment, ischemia/reperfusion (I/R) injury triggers inflammation, which contributes to infarct expansion and subsequent cardiac remodeling and wound healing. The immune response is comprised of subsets of both myeloid and lymphoid-derived cells that act in concert to modulate the pathogenesis and resolution of I/R injury. Multiple mechanisms, including altered metabolic status, regulate immune cell activation and function in the setting of acute MI, yet our understanding remains incomplete. While numerous studies demonstrated cardiac benefit following strategies that target inflammation in preclinical models, therapeutic attempts to mitigate I/R injury in patients were less successful. Therefore, further investigation leveraging emerging technologies is needed to better characterize this intricate inflammatory response and elucidate its influence on cardiac injury and the progression to heart failure.
Ionization Radiation-Induced Reliability Degradation of SiC Power MOSFET

The long-term reliability of SiC power MOSFETs under total ionizing dose (TID) effects was investigated in this article. Time-dependent dielectric breakdown (TDDB) test showed that the degradation behavior of the gate leakage current is dependent on the bias voltage. At a critical gate bias of 43.5 V, the gate leakage current first increases and then decreases before oxide breakdown. In this case, the effects of hole trapping, interface trap depassivation, as well as electron trapping during Fowler–Nordheim (FN) tunneling occur sequentially within the oxide, as described by the composite model. After total dose radiation, the oxide breakdown time is markedly reduced, while the leakage current degradation pattern remains unchanged. This is attributed to radiation-induced oxide trapped charges and additional acceptor-type defects, which modulate the oxide electric field and alter the FN tunneling barrier.
Application of Nanoparticles in Cancer Treatment: A Concise Review

Timely diagnosis and appropriate antitumoral treatments remain of utmost importance, since cancer remains a leading cause of death worldwide. Within this context, nanotechnology offers specific benefits in terms of cancer therapy by reducing its adverse effects and guiding drugs to selectively target cancer cells. In this comprehensive review, we have summarized the most relevant novel outcomes in the range of 2010–2023, covering the design and application of nanosystems for cancer therapy. We have established the general requirements for nanoparticles to be used in drug delivery and strategies for their uptake in tumor microenvironment and vasculature, including the reticuloendothelial system uptake and surface functionalization with protein corona. After a brief review of the classes of nanovectors, we have covered different classes of nanoparticles used in cancer therapies. First, the advances in the encapsulation of drugs (such as paclitaxel and fisetin) into nanoliposomes and nanoemulsions are described, as well as their relevance in current clinical trials. Then, polymeric nanoparticles are presented, namely the ones comprising poly lactic-co-glycolic acid, polyethylene glycol (and PEG dilemma) and dendrimers. The relevance of quantum dots in bioimaging is also covered, namely the systems with zinc sulfide and indium phosphide. Afterwards, we have reviewed gold nanoparticles (spheres and anisotropic) and their application in plasmon-induced photothermal therapy. The clinical relevance of iron oxide nanoparticles, such as magnetite and maghemite, has been analyzed in different fields, namely for magnetic resonance imaging, immunotherapy, hyperthermia, and drug delivery. Lastly, we have covered the recent advances in the systems using carbon nanomaterials, namely graphene oxide, carbon nanotubes, fullerenes, and carbon dots. Finally, we have compared the strategies of passive and active targeting of nanoparticles and their relevance in cancer theranostics. This review aims to be a (nano)mark on the ongoing journey towards realizing the remarkable potential of different nanoparticles in the realm of cancer therapeutics.
Blood Health Indicators Changes Induced by Replacing Fish meal with Lentil seed meal in the Common Carp (Cyprinus carpio L.)

According to the research, substituting a fish meal with a plant protein source in a fish diet presents several difficulties. As a result, the goal of this study was to evaluate the effects of substituting lentil seed meal meal for fish meal in the diet of Cyprinus carpio using a variety of blood health indices. Five different diets were created by replacing FM with 0 (control), 5, 10, 15, and 20% lentil seed meal meal. A total of 150 common carp with an initial weight of 103.8±0.5g are randomly distributed into 15 tanks for 70 days, at a rate of 3% live weight per day and two times each day. Blood samples were obtained from five fish in each tank at the end of the feeding trial to analyze hematological and biochemical parameters. Hematological and differential leukocyte counts showed no significant changes (p<0.05). Also, dietary treatments had no effect on serum glucose and total proteins (Albumin and Globulin). However, serum enzyme activity (alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP)), triglycerides, and total cholesterol were increased significantly (p<0.05) as the amount of lentil seed meal meal in the diet grew. According to the findings of this study, the maximum amounts of lentil seed meal replacement in Cyprinus carpio diets might be between 15 and 20% of total protein sources without causing adverse effects on hematological and certain plasma biochemical markers. Keywords: Biochemical, Common Carp, Hematology, Plant Protein
Borehole geotechnical testing tool for lunar exploration

Soil mechanics study plays a key role in various engineering problems relating to future lunar/planetary surface explorations. In-situ measurement of regolith physical properties is of fundamental importance in developing a framework of lunar/planetary soil mechanics. An in-situ soil investigation package; LSM (lunar soil mechanics investigation system) is being developed as a moon utilization payload for Japan's Moon lander SELENE-2, which is planned as a follow-on program of Kaguya program (SELENE). This paper focuses on a soil testing tool, which is one of the subsystems of LSM, and describes a result of laboratory experiments using a prototype model. The equipment developed is a small-diameter tool with a paired-inflatable blade and is used in a pre-frilled borehole for performing two types of soil mechanics test; lateral loading test and direct shear test against the borehole sidewall. In this study, a series of shear tests were demonstrated with a Japanese lunar soil simulant (FJS-1) and the results were compared with results of a triaxial compression test and direct shear box test. The test results showed that the proposed method has a great potential to be a reliable tool that can provide strength parameters on the lunar surface. The characteristics and underlying limitations of the probe were also discussed for future improvements.
Social Support as a Moderator of Self Efficacy and Learning Motivation Towards Students' Academic Hardiness

This research examined the factors that influence academic hardiness in tahfiz lessons. The author suspects that the factors contained in the social support variable are moderator variables for the variables self-efficacy, learning motivation, and gender which influence academic hardiness. This research uses a quantitative approach with multiple regression analysis. The sample consisted of 150 students in class 5 and class 6 of Islamic school X who were taken using a purposive sampling technique. In this research, the measuring tool used is the revised academic hardiness scale (RAHS) to measure the academic hardiness variable. Multi-Dimensional Scale of social support (Zimmet et al., 1988) to measure social support variables. The self-efficacy scale will be measured based on Bandura's theory to measure the dimensions of magnitude, generality, and strength. Learning motivation is measured using intrinsic and extrinsic aspects (Woolfolk, 1995). The research results show three significant regression coefficients: self-efficacy, intrinsic learning motivation, and gender. All three are influenced by social support, increasing students' academic hardiness. The author hopes that the implications of the results of this research can be reviewed and developed in further research. For example, adding other variables related to academic hardiness, such as parental and learning styles.
Assessment of university students’ energy saving behavior by integrating stimulus-organism-response (SOR) and the theory of planned behavior (TPB)

Concerned about balancing issues of global warming and economic growth, the growing needs of energy consumption in contexts with limited production and resources have created a serious challenge for developing countries like Pakistan. Research approaches that focus mainly on the production or purchase of environmentally friendly products or assessment of the stance of employees and households are not seen as sufficient to present the full picture of any society regarding energy saving behaviors (ESB). The attitudes and behaviors of the student population have generally not been sufficiently presented in energy saving studies to reflect current or emerging realities. Two leading behavioral theories, stimulus-organism-response theory (SOR) and the theory of planned behavior (TPB), and their relevant variables are integrated in this study to unpack the ESB of university-going students in Pakistan. Through an online survey, 410 university students from the four main urban cities of Pakistan participated in the study. The findings revealed that media and organizational climate have significantly created both a sense of social pressure and responsibility among students to cultivate stronger intentions and actions toward saving energy. The results further indicated that these behavioral intentions do indeed have a strong impact on students reported ESB. Overall, the students appeared to have been effectively influenced to be more active in saving energy for their society and country. The findings also validate the selected energy-related constructs and predictive paths in the proposed integrated SOR and TPB model. This study shows the potential for the further testing and application of the variables and this model in other contexts with other populations as the world grapples with energy shortages and global climate change issues.
Piecing it together: atrophy profiles of hippocampal subfields relate to cognitive impairment along the Alzheimer’s disease spectrum

Introduction People with Alzheimer’s disease (AD) experience more rapid declines in their ability to form hippocampal-dependent memories than cognitively normal healthy adults. Degeneration of the whole hippocampal formation has previously been found to covary with declines in learning and memory, but the associations between subfield-specific hippocampal neurodegeneration and cognitive impairments are not well characterized in AD. To improve prognostic procedures, it is critical to establish in which hippocampal subfields atrophy relates to domain-specific cognitive declines among people along the AD spectrum. In this study, we examine high-resolution structural magnetic resonance imaging (MRI) of the medial temporal lobe and extensive neuropsychological data from 29 amyloid-positive people on the AD spectrum and 17 demographically-matched amyloid-negative healthy controls. Methods Participants completed a battery of neuropsychological exams including select tests of immediate recollection, delayed recollection, and general cognitive status (i.e., performance on the Mini-Mental State Examination [MMSE] and Montreal Cognitive Assessment [MoCA]). Hippocampal subfield volumes (CA1, CA2, CA3, dentate gyrus, and subiculum) were measured using a dedicated MRI slab sequence targeting the medial temporal lobe and used to compute distance metrics to quantify AD spectrum-specific atrophic patterns and their impact on cognitive outcomes. Results Our results replicate prior studies showing that CA1, dentate gyrus, and subiculum hippocampal subfield volumes were significantly reduced in AD spectrum participants compared to amyloid-negative controls, whereas CA2 and CA3 did not exhibit such patterns of atrophy. Moreover, degeneration of the subiculum along the AD spectrum was linked to a significant decline in general cognitive status measured by the MMSE, while degeneration scores of the CA1 and dentate gyrus were more widely associated with declines on the MMSE and tests of learning and memory. Discussion These findings provide evidence that subfield-specific patterns of hippocampal degeneration, in combination with cognitive assessments, may constitute a sensitive prognostic approach and could be used to better track disease trajectories among individuals on the AD spectrum.
Resistance Rule of Mud Flows on Movable and Fixed Beds

A nondimensional parameter governing debris and mud flows and dry-grain flow is derived from the comparison between intergranular-stress and inertia terms in the momentumu equations. From the result nondimensional distance from the bed is introduced for velocity profile of these flows. Granular and inertial sublayers are found to exist near the bed in the flows. The former sublayer has linear velocity profile due to the major role of intergranular stresses, while the latter sublayer has logarithmic velocity profile due to the inertial forces.Nondimensional surface velocityus/u*and average velocityu/u*are calculated and the results are compared with the experimental ones.
Black or white is not always delineated: The influence of moral disengagement and clawbacks on the intention to manipulate accrual earnings and real activity

Abstract The purpose of this study is to examine the effectiveness of clawback to minimize earnings management due to moral disengagement tendencies. To understand the phenomenon of earnings manipulation, as well as the propensity for moral disengagement, we turn to the agency theory and the social cognition theory. In addition, clawback is explained by the supernatural monitoring hypothesis as a tool to lessen earnings manipulation. To test the hypotheses, an experimental study was conducted using a within-subject design. The participants were professional accountants who were pursuing master’s level studies. We found that moral disengagement is preceded by an ethical orientation. More importantly, we found the impact of ethical orientation on intentions for managing earnings is mediated by moral disengagement. Further, we found the clawback scheme reduces the effect of moral disengagement on intentions to manipulate earnings. More specifically, the results show that when adopting a clawback strategy, moral disengagement significantly increases the intention to manipulate accruals but does not significantly affect the intention to manipulate real activity. The results suggest that seriously considering individual characteristics and implementing appropriate incentive programs may lead to a high standard of financial reporting.
Late Cretaceous mosasauroids (Reptilia, Squamata) of the Big Bend region in Texas, USA

ABSTRACT Upper Cretaceous marine rocks of the Big Bend Region of trans-Pecos Texas preserve a number of marine-adapted mosasauroids. At least three unnamed taxa of basal mosasauroids are represented by remains from shaly limestones in the middle Turonian portion of the Boquillas Formation. These occur along with remains of larger derived mosasaurs referable to Russellosaurina and an undescribed tylosaurine. Derived mosasaurs from the middle to late Coniacian include the first report of Tylosaurus kansasensis outside of Kansas, T. nepaeolicus, Platecarpus planifrons, and Platecarpus aff. P. planifrons. Clidastes liodontus is found in the latest Coniacian or early Santonian part of the Pen Formation. An undescribed species of Ectenosaurus, Clidastes sp. and an indeterminate plioplatecarpine occurs in the middle Santonian to early Campanian interval of the Pen Formation. The mosasaur fauna from the Big Bend region is quite similar to that from the Smoky Hill Chalk of Kansas, a thousand kilometres to the north. We refine the position of the Cenomanian–Turonian boundary within the Ernst Member of the Boquillas Formation, based on ammonite faunas. We also corroborate previous interpretations describing the time-transgressive nature of the onset of deposition of the Pen Formation based on a west-to-east descending level of the Inoceramus (Cremnoceramus) undulatoplicatus FAD.
Aquatic and Terrestrial Invertebrate Welfare

Simple Summary Invertebrates (animals without backbones) make up over 95% of the earth’s species yet compared with vertebrates (animals with backbones like fishes, amphibians, reptiles, birds, and mammals) our understanding of and efforts relating to the topic of welfare is relatively minimal. We have selected seven of the most economically important and widely recognized invertebrate taxa to focus the topic of animal welfare on. In these pages the reader will learn about coelenterates (jellyfishes, anemones, and corals), mollusks (snails, slugs, squid, and octopi), crustaceans (lobsters, crabs, and shrimp), echinoderms (sea stars, sea urchins, and sea cucumbers), chelicerates (spiders, scorpions, and horseshoe crabs), myriapods (centipedes and millipedes), and insects (butterflies, honeybees, and fruit flies). In addition to discussing the welfare of these species, other topics, including anatomy, physiology, husbandry, natural history, and environmental diseases, are reviewed. Abstract Invertebrates are a diverse group of animals that make up the majority of the animal kingdom and encompass a wide array of species with varying adaptations and characteristics. Invertebrates are found in nearly all of the world’s habitats, including aquatic, marine, and terrestrial environments. There are many misconceptions about invertebrate sentience, welfare requirements, the need for environmental enrichment, and overall care and husbandry for this amazing group of animals. This review addresses these topics and more for a select group of invertebrates with biomedical, economical, display, and human companionship importance.
Cognitive Behaviour Therapy to Reduce Communication Apprehension in Students Who Are Working on Thesis

The complexity of writing a thesis causes difficulties or obstacles for students, which can result in the emergence of anxiety symptoms. This study aims to determine whether the Cognitive Behaviour Therapy (CBT) approach can reduce the level of communication apprehesion experienced by students who are working on a thesis. Study 1 used a quantitative experimental method with a non-control group design and study 2 used a qualitative method. The participants in this study were 5 students from one of the universities in Surabaya. The results of study 1 show that providing interventions in the form of group counseling with a CBT approach can reduce the level of communication apprehension experienced by students who are working on their thesis. The results of study 2 show that group members can change their cognitive distortions so that they have a more positive thought process. Group members are also able to apply CBT strategies that have been done together to reduce their communication anxiety so that it can increase the effectiveness of communication in preparing the thesis. ABSTRAK Kompleksitas penulisan skripsi menimbulkan kesulitan ataupun kendala bagi mahasiswa, yang dapat berakibat munculnya gejala-gejala kecemasan. Penelitian ini bertujuan untuk mengetahui apakah pendekatan Cognitive Behaviour Therapy (CBT) dapat menurunkan tingkat kecemasan komunikasi yang dialami oleh mahasiswa yang sedang mengerjakan skripsi. Studi 1 menggunakan metode kuantitatif eksperimen dengan non control group design dan studi 2 menggunakan metode kualitatif. Partisipan dalam penelitian ini adalah 5 orang mahasiswa dari salah satu universitas di Surabaya. Hasil studi 1 menunjukkan bahwa pemberian intervensi berupa konseling kelompok dengan pendekatan CBT dapat menurunkan tingkat kecemasan komunikasi yang dialami oleh mahasiswa yang sedang mengerjakan skripsi. Hasil studi 2 menunjukkan bahwa anggota kelompok dapat mengubah distorsi kognitifnya sehingga memiliki proses berpikir yang lebih positif. Anggota kelompok pun mampu untuk menerapkan strategi-strategi CBT yang telah dilakukan bersama untuk menurunkan kecemasan komunikasinya sehingga dapat meningkatkan keefektifan komunikasi dalam penyusunan skripsi.
An Assessment of WorldView-1 Positional Accuracy based on Fifty Contiguous Stereo Pairs of Imagery

This paper presents an assessment of WorldView-1 3D positional extraction accuracy based on 50 overlapping and contiguous stereo pairs of WorldView-1 imagery covering approximately 50,000 square kilometers of the earth's surface. Absolute accuracy is both predicted using error propagation and measured using reference points. Shear, a form of relative accuracy, is also assessed between each overlapping stereo pair of images. Accuracy is assessed for two different processing approaches: extraction from individual stereo pairs, and extraction from stereo pairs following the fusion of information across all overlapping stereo pairs. The latter approach was implemented with Metric Information Network (MIN) processing, an efficient process with results equivalent to a simultaneous block adjustment. Both approaches used no ground control, although in a separate sub-experiment, MIN processing was supplemented with a sparse set of ground control (GPS surveyed) points.
Accounting for sea surface variation in deghosting - a novel approach applied to a 3D dataset offshore west Africa

The ghosting effect of towed marine seismic data is controlled by the acquisition geometry and the sea state. Deterministic methods of deghosting typically require accurate depth information for every receiver along the length of the streamer within decimetres. Any minor inaccuracy in this information can lead to characteristic ringing through application of the deghosting operator in the wrong frequency. In practice neither the sea surface is flat nor do the receivers remain at their nominal depths; measurements themselves are sparser and generally interpolated. The position of the receiver-ghost notch frequency is dynamic, varying for every receiver in every shot gather which is augmented in higher sea states.
Generic strategic positioning and organizational configurations in private micro-clinics

By linking concepts and ideas from the private health services (PHS) and Knowledge-Intensive Business Services (KIBS) literature with Porter's generic framework, this paper aims to identify the competitive positioning at a micro-clinic level in the private health services industry and to examine the perceived role of the institutions and intellectual capital associated with each one. A Qualitative Comparative Analysis (QCA) was used.The results show that organizational configurations are associated with proactivity when competing via differentiation. In contrast, cost leadership is linked to firms that compete with low tariffs and a defensivearchetype. Our work can serve as a basis to recommend specific competitive strategies for thehigh number of firms still following a stuck-in-the-middle positioning strategy.