Miracle-dz/UniFAR-FTUs huggingface dataset:
The Prognostic Role of Intratumoral Stromal Content in Lobular Breast Cancer

Simple Summary High intratumoral stromal content is related to worse outcomes in several types of cancer. However, its prognostic role in breast cancer seems to differ between different subtypes. High intratumoral stromal content is a negative prognostic marker in triple-negative breast cancer, while the opposite is the case for estrogen-receptor-positive breast cancer, in which higher stromal content is indicative of a better prognosis. Most lobular breast cancers are estrogen-receptor-positive, and the tumor tissue has a clearly defined histological appearance, often with a high intratumoral stromal content. To date, the prognostic role of intratumoral stromal content in lobular breast cancer remains unclear. In this study, we aimed to investigate the prognostic importance of intratumoral stromal content in estrogen-receptor-positive lobular breast cancer. Our results show that high intratumoral stromal content is an easily assessed and clinically useful indicator of a good prognosis in lobular breast cancer. Abstract Previous studies have shown that high intratumoral stromal content is associated with a worse prognosis in breast cancer, especially in the triple-negative subtype. However, contradictory results have been reported for estrogen-receptor-positive (ER+) breast cancer, indicating that the prognostic role of intratumoral stromal content may be subtype-dependent. In this study, we investigated the importance of intratumoral stromal content for breast cancer-specific mortality (BCM) in a well-defined subgroup (n = 182) of ER+/human-epidermal growth-factor-receptor-2 negative (HER2−) invasive lobular breast cancer (ILC). The intratumoral stromal content was assessed on hematoxylin–eosin-stained whole sections and graded into high stroma (>50%) or low stroma (≤50%). A total of 82 (45%) patients had high-stroma tumors, and 100 (55%) had low-stroma tumors. High-stroma tumors were associated with a lower Nottingham histological grade, low Ki67, and a luminal A-like subtype. After a 10-year follow-up, the patients with high-stroma tumors had a lower BCM (HR: 0.43, 95% CI: 0.21–0.89, p = 0.023) in univariable analysis. Essentially the same effect was found in both the multivariable analysis (10-year follow-up) and univariable analysis (25-year follow-up), but these findings were not strictly significant. In ER+/HER2− ILC, high intratumoral stromal content is an easily assessable histological indicator of a good prognosis.
Development of self-concept clarity from ages 11 to 24: Latent growth models of Chinese adolescents

ABSTRACT This study examined the growth trajectory of self-concept clarity (SCC) and explored the influence of this trajectory on the development of life satisfaction (LS) and positive affect (PA) among Chinese adolescents (N = 2001, 56.97% females). Results of latent growth models showed no significant mean-level change of SCC across three waves in a year. However, significant inter-individual variability was presented in the developmental patterns of SCC over time. Specifically, older adolescents showed higher initial levels of SCC; and males were related to increased SCC in development rates. Moreover, we found gender-specific nature of the relationship between SCC and well-being outcomes (e.g., LS and PA). Our results have significant practical implications for mental health programs in adolescence.
The Influence of Ownership Structure, Debt Structure, and Independent Commissioner on Earning Management

This study aims to examine the effect of independent commissioners, blockholder ownership, long-term debt, short-term debt, institutional ownership, family ownership, and managerial ownership on earnings management. This study is a quantitative study with a sample of 71 companies listed on the Indonesia Stock Exchange in 2017-2019. The data is processed by multiple regression using E-views. The results show that long-term debt has a negative effect on earnings management and short-term debt has a positive effect on earnings management. Other results show that independent board of commissioners, blockholder ownership, institutional ownership, family ownership, and managerial ownership do not cause earnings management. The limitation of this study is that it does not use a sample in the financial sector. Nevertheless, this research contributes practically and theoretically. This study also facilitates the weaknesses of previous research by adding variables of debt structure and ownership structure.
The Effects of Park Based Interventions on Health: The Italian Project “Moving Parks”

Obesity and physical inactivity are global health problems responsible for the risk increment of noncommunicable diseases. To overcome these problems, interventions aimed at increasing physical activity (PA) are necessary. Green space can have a positive influence on promoting PA, so, the aim of the present study was to assess the effectiveness of the project “The moving parks project”, which provides for the administration of PA to citizens within Bologna’s parks (Italy). An ad hoc questionnaire was administered before and after three months of outdoor PA. A total of 329 adult subjects participated in the survey. At follow-up, all psychosocial parameters showed an improvement, with a reduction in the state of tension, sadness and fatigue, and an improvement in the state of energy, serenity, and vitality. The impact of the interventions carried out in the “Moving Parks project” was positive and appears to be a good strategy for improving health outcomes.
The 29 July 2021 MW 8.2 Chignik, Alaska Peninsula Earthquake Rupture Inferred From Seismic and Geodetic Observations: Re‐Rupture of the Western 2/3 of the 1938 Rupture Zone

On 29 July 2021, an MW 8.2 thrust‐faulting earthquake ruptured offshore of the Alaska Peninsula within the rupture zone of the 1938 MW 8.2 earthquake. The spatiotemporal distribution of megathrust slip is resolved by jointly inverting regional and teleseismic broadband waveforms along with co‐seismic static and high‐rate GNSS displacements. The primarily unilateral rupture expanded northeastward, away from the rupture zone of the 22 July 2020 MW 7.8 Shumagin earthquake. Large slip extends along approximately 175 km, spanning about two third of the estimated 1938 aftershock zone, with well‐bounded depth from 20 to 40 km, and up to 8.6 m slip near the hypocenter. The rupture terminated in the eastern portion of the 1938 aftershock zone in a region of very large geodetic slip deficit where peak slip appears to have occurred in the 1938 rupture. The 2021 and 1938 events do not have similar slip distributions and do not indicate persistent asperities.
Toward the Personalization of Biceps Fatigue Detection Model for Gym Activity: An Approach to Utilize Wearables’ Data from the Crowd

Nowadays, wearables-based Human Activity Recognition (HAR) systems represent a modern, robust, and lightweight solution to monitor athlete performance. However, user data variability is a problem that may hinder the performance of HAR systems, especially the cross-subject HAR models. Such a problem may have a lesser effect on the subject-specific model because it is a tailored model that serves a specific user; hence, data variability is usually low, and performance is often high. However, such a performance comes with a high cost in data collection and processing per user. Therefore, in this work, we present a personalized model that achieves higher performance than the cross-subject model while maintaining a lower data cost than the subject-specific model. Our personalization approach sources data from the crowd based on similarity scores computed between the test subject and the individuals in the crowd. Our dataset consists of 3750 concentration curl repetitions from 25 volunteers with ages and BMI ranging between 20–46 and 24–46, respectively. We compute 11 hand-crafted features and train 2 personalized AdaBoost models, Decision Tree (AdaBoost-DT) and Artificial Neural Networks (AdaBoost-ANN), using data from whom the test subject shares similar physical and single traits. Our findings show that the AdaBoost-DT model outperforms the cross-subject-DT model by 5.89%, while the AdaBoost-ANN model outperforms the cross-subject-ANN model by 3.38%. On the other hand, at 50.0% less of the test subject’s data consumption, our AdaBoost-DT model outperforms the subject-specific-DT model by 16%, while the AdaBoost-ANN model outperforms the subject-specific-ANN model by 10.33%. Yet, the subject-specific models achieve the best performances at 100% of the test subjects’ data consumption.
New-Born Screening for Spinal Muscular Atrophy: Results of a Latvian Pilot Study

New disease-modifying treatments have recently been approved for 5q spinal muscular atrophy (SMA) and early treatment has been associated with a better clinical outcome. Accordingly, new-born screening (NBS) for SMA should be implemented to ensure early diagnosis of affected individuals. The aim of this study was to determine the feasibility and usefulness of NBS for SMA in Latvia. Between February and November of 2021, 10,411 parents consented to participation in the study. DNA testing for the SMN1 exon 7 homozygous deletion was conducted using qPCR with fluorescent locked nucleic acid primers. In the first month of testing, reporting of results took up to a maximum of 17 days after samples arrived in the laboratory. However, following familiarisation with the procedure, the median report time was reduced to 11 days after birth. Forty cases required samples to be taken again due to poor quality of the isolated DNA transpiring from either the quality of the blood punch or manual mistakes during DNA isolation. The SMN1 exon 7 homozygous deletion was identified in two individuals, which was subsequently confirmed by multiplex ligation-dependent probe amplification. When a NBS sample is taken 48 to 72 h after birth and transported to the laboratory within two working days after collection according to legal requirements, DNA test results can be reported to healthcare professionals before the 12th day of life. Expansion of our SMA 5q NBS procedure to the whole of Latvia is feasible and would facilitate early diagnosis and result in more effective treatment. We strongly advocate that SMA is added to the national Latvia Recommended Uniform Screening Panel.
SUSCEPTIBILITY OF THE ALBINO NORWAY RAT, Rattus norvegicus TO CERTAIN ANTIOCOAGULANT RODENTICIDES.

Laboratory studies were carried to investigate the susceptibility of three anticoagulant rodenticides, Brodifacoum, Chlorophacinone and Warfarin on both sexes of albino Norway rat, R. norvegicus which were fed on either equally mixture of maize and wheat or vegetables. The obtained results could be summarized in the following:ADetermination of LD values of three anticoagulant rodenticides:The final results proved that males of R. norvegicus which fed on either mixture of wheat and maize or vegetables were more tolerant than females approximately. In addition, the gained figures cleared that both sexes of R. norvegicus which fed on mixture of wheat and maize were more susceptible to Chlorophacinone than Brodifacoum and Warfarin. In spite of, the tested animals which fed on vegetables were more susceptible to Brodifacoum, they had tolerance to Warfarin. BEffect of /10 of LD values of the tested anticoagulant rodenticides on bleeding time of both sexes of R. norvegicus:The results in case of feeding on maize and wheat showed a highly significant differences between rodenticides after 24, 48 and 72h at /10LD90 and /10LD50, while there was no any significant difference after 48 and 72h post-treatment. The effect of /10LD90 and /10LD50 of the tested rodenticides on bleeding time of R. norvegicus which fed on maize and wheat could be arranged according to their effectiveness in descending order as follows; Brodifacoum > Chlorophacinone > Warfarin. Also, results showed no significant difference between replicates and sexes at the three periods of bleeding time whereas, in the case of feeding on vegetables, the results revealed a highly significant differences between treatments at the dose of /10LD90. Also, the results showed a highly significant differences between the investigated doses during three periods in the two cases of feeding except for the Warfarin treatment after 72h.
THE INFLUENCE OF PROBIOTIC AND ENZYME MIXTURE CONTAINING PHYTASE ON GROWTH PERFORMANCE, CARCASS CHARACTERISTICS, MEAT QUALITY AND PLASMA BIOCHEMICAL CONSTITUENTS OF BROILER CHICKS FED DIFFERENT PLANT PROTEIN SOURCES

The influence of different dietary protein sources and two types of pro-nutrients e.g. enzyme mixture containing phytase and probiotics on growth performance, carcass characteristics, meat quality and plasma biochemical constituents of broiler chicks was studied herein as means of improving the utilization of diets containing different plant protein sources and decreasing feed cost. A complete randomized straight run experimental design including 10 dietary treatments was conducted. A basal control corn-soybean meal diet containing 22 and 20% CP in the starting and growing-finishing periods, respectively was formulated. Sunflower meal (SFM) and rocket (Eruca sativa) meal (RM) individually or as a mixture of (1:1; Wt::Wt ) replaced 25% of soybean meal protein. Thus, there were four main experimental diets. Moreover, the diets containing SFM and/or RM was either supplemented or not with enzyme mixture containing phytase (Natuzyme) or probiotics (Nutri-Bio Plus). Thus, there were 10 experimental treatments, Each diet was fed to 24 one d-old unsexed broiler chicks divided equally among four replicates of 6 chicks each housed in a battery (30×35×40 cm). At the end of the experiment (49 d of age), 3 chicks of each treatment were slaughtered to determine carcass characteristics and meat quality traits. Furthermore, four blood samples per treatment were collected to determine some biochemical constituents. Also, a digestibility trail and an economic efficiency study were carried out. Although, substituting 25% of soybean meal protein by SMF and/or RM had no adverse effect on growth or feed conversion ratio (FCR) it improved protein conversion ratio (PCR) and economic efficiency of broiler chicks. Furthermore, Natuzyme and probiotics supplementation significantly improved growth, FCR, PCR and the economic efficiency, with the effect of probiotics was more efficient. Feed intake was significantly decreased due to inclusion of SFM and/or RM and further decreased by enzymes and probiotic supplementation, however, the effect of probiotics was stronger than enzymes. Enzyme supplementation improved significantly digestibility of dry matter of diet containing a mixture of SFM and RM. Sunflower meal and/or RM had no effect on dressing percentage, front and hind parts, meat quality and plasma total protein, globulin and albumin/globulin ratio, total lipids, cholesterol, inorganic phosphorous (iP), Ca and AST and ALT enzymes. In conclusion, SFM and/or RM could be included in broiler diets to replace 25% of soybean meal protein without adverse effects on growth performance and economic efficiency. Furthermore, enzyme mixture and probiotics supplementation resulted in improved growth performance and economic efficiency. Whereas, probiotic supplemented-diet containing a mixture of SFM and RM resulted in the best productive performance and economic efficiency.
Efficacy of ChAdOx1 vaccines against SARS-CoV-2 Variants of Concern Beta, Delta and Omicron in the Syrian hamster model

ChAdOx1 nCoV-19 (AZD1222) is a replication-deficient simian adenovirus–vectored vaccine encoding the spike (S) protein of SARS-CoV-2, based on the first published full-length sequence (Wuhan-1). AZD1222 was shown to have 74% vaccine efficacy (VE) against symptomatic disease in clinical trials and over 2.5 billion doses of vaccine have been released for worldwide use. However, SARS-CoV-2 continues to circulate and consequently, variants of concern (VoCs) have been detected, with substitutions in the S protein that are associated with a reduction in virus neutralizing antibody titer. Updating vaccines to include S proteins of VoCs may be beneficial over boosting with vaccines encoding the ancestral S protein, even though current real-world data is suggesting good efficacy against hospitalization and death following boosting with vaccines encoding the ancestral S protein. Using the Syrian hamster model, we evaluated the effect of a single dose of AZD2816, encoding the S protein of the Beta VoC, and efficacy of AZD1222/AZD2816 as a heterologous primary series against challenge with the Beta or Delta variant. We then investigated the efficacy of a single dose of AZD2816 or AZD1222 against the Omicron VoC. As seen previously, minimal to no viral sgRNA could be detected in lungs of vaccinated animals obtained at 5 days post inoculation, in contrast to lungs of control animals. Thus, these vaccination regimens are protective against the Beta, Delta, and Omicron VoCs in the hamster model.
Impact of Biochar on Rhizosphere Bacterial Diversity Restoration Following Chloropicrin Fumigation of Planted Soil

Chloropicrin (CP) can effectively combat soil-borne diseases but has significant side effects on nontarget microorganisms. The rhizosphere microflora play a crucial role in promoting plant growth and protecting plants from infection by soil-borne pathogens. We conducted a laboratory pot experiment to evaluate the effect of CP on the rhizosphere soil bacterial flora and the effect of biochar amendments on the reconstruction of microbial communities. Our results show that CP fumigation and biochar additions promoted the growth of cucumber plants in the later stage of the pot experiment. CP significantly inhibited the rhizobacterial diversity and changed the community composition. Biochar amendments after CP fumigation shortened the time for the rhizobacterial diversity to recover to unfumigated levels. Biochar amendments promoted the transplantation of new populations to empty microbiome niches that were caused by CP and, in particular, stimulated many beneficial microorganisms to become the predominant flora. The relative abundances of many functional taxa related to plant-disease suppressiveness and pollutant bioremediation increased, including Pseudomonas, Stenotrophomonas, Bacillus, Massilia, Acinetobacter, Delftia, Micromonospora, Cytophagaceae, and Flavisolibacter. These changes stimulated by biochar amendments would promote multifunctionality in the soil rhizosphere and benefit plant growth and disease resistance.
Simple and Efficient LoRa Receiver Scheme for Multipath Channel

This article presents a novel long-range (LoRa) receiver operating in the frequency selective multipath channel (MPC). The dechirped received LoRa waveforms under MPC allows us to derive a simple and efficient LoRa receiver scheme by using a matched filter (MF) approach that aims to maximize the signal-to-noise ratio (SNR) at the symbol index frequency of the discrete Fourier transform (DFT) output. We show that the MF receiver can be seen as a RAKE structure where interference peaks related to multipath, exhibited at DFT output, are recombined in a constructive way. Detection performance is driven by channel energy and the benefit of this novel MF/RAKE receiver over original coherent and noncoherent receiver appears only for MPC that exhibits significant paths energy. These two MF and RAKE receivers have however different implementation complexities that are studied in detail. We provide in that sense recommendations on which receiver variant to use for real operations, depending on complexity constraints. Finally, the proposed MF/RAKE receiver outperforms previous results on time-delay estimation LoRa (TDEL) receiver over MPC, especially at low SNR and higher LoRa spreading factor (SF) parameter, at the cost of higher but reasonable complexity.
Research Progress on Neuroprotection of Insulin-like Growth Factor-1 towards Glutamate-Induced Neurotoxicity

Insulin-like growth factor-1 (IGF-1) and its binding proteins and receptors are widely expressed in the central nervous system (CNS), proposing IGF-1-induced neurotrophic actions in normal growth, development, and maintenance. However, while there is convincing evidence that the IGF-1 system has specific endocrine roles in the CNS, the concept is emerging that IGF-I might be also important in disorders such as ischemic stroke, brain trauma, Alzheimer’s disease, epilepsy, etc., by inducing neuroprotective effects towards glutamate-mediated excitotoxic signaling pathways. Research in rodent models has demonstrated rescue of pathophysiological and behavioral abnormalities when IGF-1 was administered by different routes, and several clinical studies have shown safety and promise of efficacy in neurological disorders of the CNS. Focusing on the relationship between IGF-1-induced neuroprotection and glutamate-induced excitatory neurotoxicity, this review addresses the research progress in the field, intending to provide a rationale for using IGF-I clinically to confer neuroprotective therapy towards neurological diseases with glutamate excitotoxicity as a common pathological pathway.
What Is the Effect of Cultural Greenway Projects in High-Density Urban Municipalities? Assessing the Public Living Desire near the Cultural Greenway in Central Beijing

Cultural greenway projects (CGPs) are widely regarded as an urban planning approach which connects open green spaces and sites of sociocultural value to provide access to living, working and recreational spaces and enhance local social well-being. This paper examines the impact of such CGPs on public living desire before and after a given project is completed through analyzing housing prices in the surrounding area. We deployed a hedonic pricing model (HPM) and differences in differences (DID) model to analyze and record any changes in housing market trends that may have been caused by such a cultural greenway project. Via analysis of single-family home sale transactions in central Beijing from 2013 to 2017, we found substantial evidence that proximity to a cultural greenway project is positively linked with rising property prices. Once complete, CGPs were similarly associated with positive increases per HPM and DID modeling. Our results revealed that the distance to greenway contributed significantly positive impact on the housing market after the cultural greenway project completed. Moreover, our result indicated that once a CGP was open to the public, it increased the price of properties within 1 km by 13.3%. Seller and buyer expectations of the development of local, green public infrastructure also began to factor into housing prices prior to the greenway opening to the public. Post-completion, the positive trend in property pricing due to local CGPs indicates that the public still have an increasing desire to live near the greenway. These results will help policymakers better understand how cultural greenways affect neighborhoods in high-density urban contexts, and will support the development of urban greenway policies for cities in China that reap the maximum economic benefit.