Miracle-dz/UniFAR-FTUs huggingface dataset:
Preventive and Therapeutic Effect of Lindley Eupatorium Herb on Experimental Hyperpidemia in Rats and Mice

OBJECTIVE:To study the preventive and therapeutic effect of Lindley eupatorium herb on experimental hyperplipidemia in rats and mice.METHODS:60 rats and 60 mice were respectively randomized to normal control group,hyperlipidemia model group,positive control group and lindley eupatorium herb groups(at high,middle and low doses). All mice except those in normal control group were injected intraperitoneally with 75%yolk 30 days after treatment with the corresponding drugs,and all the rats except the normal control group were fed on high lipid food and meanwhile being treated with the corresponding drugs for 30 days.Blood samples were taken in each group for the determination of the levels of total cholesterol(TC),triglyceride(TG),high density lipoprotein cholesterol(HDL-C)and low density lipoprotein cholesterol (LDL-C)following the last administration.RESULTS:Levels of TC,TG and LDL-C were significantly reduced while HDL-C levels were significantly increased by Lindley eupatorium herb.CONCLUSION:Lindley eupatorium herb shows marked preventive and therapeutic effect on hyperlipidemia in rats and mice.
Rotator cuff repair in the elderly: is it worthwhile?

Rotator cuff pathology is a major contributor to shoulder dysfunction, particularly in the elderly population. Elderly individuals have shown an increasing desire to remain physically active and have high expectations of treatment. The ideal method to provide pain relief and restore function is controversial, with some surgeons advocating conservative measures and others preferring surgical management. The purpose of this article was to highlight the factors that influence decision-making when treating elderly individuals with rotator cuff pathology. Current treatment recommendations with their reported clinical outcomes and possible future developments are discussed.
Effectiveness and safety of triplet combination chemotherapy compared to doublet combination chemotherapy for advanced gastric cancer: a meta-analysis

OBJECTIVE To perform a systematic review of the randomized controlled trials in advanced gastric cancer for comparing the effectiveness and safety between triplet combination chemotherapy and doublet combination chemotherapy.METHODS Cochrane strategy in combination with manual search was used to identify previously published randomized controlled trials in advanced gastric cancer by searching Cochrane library,PubMed,EMBase,China Journal Full-text Database.RESULTS Twelve randomized controlled trials were studied.The overall response rate in triplet combination chemotherapy was higher than that in doublet combination chemotherapy(OR=1.36,95% CI 1.10-1.67,P=0.004). In subgroup analysis,the overall response rate in taxanes based triplet combination chemotherapy was higher than that in doublet combination chemotherapy(OR=1.50,95% CI 1.14-1.97,P=0.000 4),the tendency was not observed in antitumor antibiotic based triplet combination chemotherapy(OR=1.21,95% CI 0.85-1.72,P=0.68). In adverse events of grade 3/4,there was no statistical significance between the triplet combination chemotherapy and doublet combination chemotherapy(P0.05). In subgroup analysis,the incidence of diarrhea of grades 3 to 4 was higher in taxanes based triplet combination chemotherapy than that in doublet combination chemotherapy(OR=3.19,95% CI 1.92-5.30,P0.05),the tendency was also not observed in antitumor antibiotic based triplet combination chemotherapy(OR=0.96,95% CI 0.35-2.63,P=0.94). CONCLUSION In advanced gastric cancer,triplet combination chemotherapy was more effective than that in doublet combination chemotherapy,especially in taxanes based triplet combination chemotherapy.In adverse events of grade 3/4,there was no statistical significance between the triplet combination chemotherapy and doublet combination chemotherapy.
Effect Observing of Methycobal Zusanli Point Injection on Treating Bell Palsy 36 Cases

Objective:In order to observe the clinical effect of methycobal Zusanli point injection on treating Bell palsy.Methods:72 patients with Bell palsy were randomly divided into treatment group and control group.The treatment group were treated by methycobal Zusanli point injection plus conventional needling. ,and control group were given conventional needling only.All the patients were assessed by use of House-Brackmann(H-B) facial nerve grading system and blink reflex before treatment and four weeks after treatment.Results:The effective rate(97.22%) and markedly effective rate(72.22%) of treatment group is higher than control group(P0.05),with effective rate of 75%,markedly effective rate of 44.44%. Conclusion:The effect of methycobal Zusanli point injection on treating Bell palsy is better than conventional needling.
Establishing of Pathological Evaluation Method for the Therapeutic Effect of Dexamethasone in a LPS-induced Mouse Acute Pneumonia Model

Dexamethasone was used as a positive drug to establish and validate a pathological evaluation method for a lipopolysaccharide(LPS) induced mouse acute pneumonia model,and develop a low-priced and easy preliminary pharmacodynamic evaluation model for the inflammatory and infectious diseases.The LPS-induced mouse acute pneumonia model was developed by the nasal inhalation of LPS.The pathology classification standard was set up via HE staining based on the lung injury severity against time points.Dexamethasone was adopted as a positive drug to validate the pathological evaluation method.After inhalation of LPS,the lungs were collected at different time points for pathological evaluation.A 0 – 5 level pathological classification standard of lung injury was established.This method was used to evaluate the therapeutic effect of the positive drug dexmethasone,and proved a significant difference between the LPS control and dexmethasone-treatment group.We established the pathological evaluation method for the therapeutic effect of dexamethasone in the LPS-induced mouse acute pneumonia model.The method can be used for the preliminary screening of anti-inflammatory drugs and their pharmacodynamic studies.
What are the challenges?

The group decided that a comprehensive and ongoing educational program would be necessary to help them develop in their various settings. After a number of group discussions and consultation with epidemiologists, experienced infection control nurses, a microbiologist, and public health nurses, the program was developed through the health sciences continuing education office at the School of Medi-
Deep Neck Infections - Classification in Levels of Severity

Introducao: As infeccoes dos espacos cervicais constituem quadros graves e que apresentam elevada mortalidade quando evoluem com complicacoes. Objetivo: Estabelecer um protocolo de graduacao dos abscessos cervicais e organizar uma sequencia para o atendimento desses pacientes. Metodo: Foi realizado um estudo retrospectivo de 150 pacientes portadores de abscesso cervical no qual se avaliou a impressao clinica, estado geral, condicao respiratoria, estado loco-regional, antibioticos utilizados e comorbidades. Apos, organizou-se a classificacao em niveis de gravidade. Resultados: A idade media foi de 31 anos e em 37% dos casos a origem era dentaria. Na avaliacao loco regional em 67% o acometimento se estendia ate nivel I e II. Conforme a gravidade, os pacientes foram classificados da seguinte maneira: Grau I (46%), II (36%), III (15%) e IV (3%). Somente antibioticoterapia foi utilizada em 27% dos casos. A associacao com cirurgia ocorreu em 73% Conclusao: A padronizacao da conduta terapeutica e a sua classificacao em gravidade e fundamental para a sistematizacao do atendimento e diminuicao da morbi-mortalidade. Palavras-chave: pescoco, condutas terapeuticas, inflamacao.
Changes of spinal cord mitochondrial respiratory function and the contents of intramitochondria free calcium in experimental spinal cord injury model

Objective:To study the changes of spinal cord mitchondrial respiratory function and the contents of intramitochondria free calcium in experimental spinal cord injury(SCI) model.Methods:Twenty-four SCI models in adult SD rats were built based on modified Allen′s method.Mitochondria was extracted from injuried spinal cord tissue by using modified Estabrook′s method 6,12,24 h after SCI.Then the respiratory function,including R3,R4,RCR,P/O and the contents of intramitochondria free calcium were measured.Results:R3,RCR and P/O of injuried spinal cord mitochondria decreased significantly 6 h,12 h and 24 h after SCI compared to the normal control group(P 0.01),but the contents of intra-mitochondria free calcium and R4 increased significantly(P 0.01). Conclusion:The results suggest that mitochondrial respiratory function decreases significantly and the contents of intramitochondria free calcium increase significantly after SCI.
Enumeration of Listeria and Enteric Bacteria of Public Health Significance on Meat Tables Before and After Sales of Meat in Ibadan Municipal Abattoir, Nigeria

A bacteriological assay was done on meat tables in Ibadan municipal abattoir, Nigeria. Swab samples from 1 cm of the surface were obtained from meat tables before and after the sales of meat. The 2 swab samples were analyzed for Listeria sp Count (LSC), Listeria monocytogenes Count (LMC), Coliform Count (CC), Enterobacteriaceae Count (EC) and Salmonella sp Count (SSC). The mean values for LSC, EC and SSC were 8.20±0.06 log10CFU/cm , 8.81±0.05 log10CFU/cm and 7.32±0.20 log10CFU/cm respectively 2 2 2 for before sales while after meat sales was 10.47±0.05 log10CFU/cm (LSC), 11.47±0.03 log10CFU/cm (EC) 2 2 and 11.37±0.04 log10CFU/cm (SSC). The mean values for before and after meat sales of Coliform Count 2 (CC) were 8.35±0.07 log10CFU/cm and 10.86±0.05 log10CFU/cm respectively while Listeria monocytogenes 2 2 Count (LMC) for before and after meat sales were 7.59±0.06 log10CFU/cm and 9.78±0.07 log10CFU/cm 2 2 respectively. The mean values (log10CFU/cm ) showed that EC> LSC>SSC for before meat sales while after 2 sales showed that EC>SSC>LSC. A significat difference (p<0.05) was observed in all the counts before and after meat sales. A positive correlation (R = 0.396) ensued for LMC and LSC before sales. Results reflect 2 poor hygienic conditions of the meat tables and non adherence to HACCP programs.
1‐Acetyl‐3‐(4‐bromophenyl)‐5‐(2‐furyl)‐2‐pyrazoline

Bruker (1997). SADABS (Version 2.01), SMART (Version 5.044), SAINT (Version 5.01) and SHELXTL (Version 5.10). Bruker AXS Inc., Madison, Wisconsin, USA. Dhal, P. N. , Acharya, T. E. & Nayak, A. (1975). J. Indian Chem. Soc. 52, 1196– 1200. Fahrni, C. J., Yang, L. C. & VanDerveer, D. G. (2003). J. Am. Chem. Soc. 125, 3799–3812. Guo, H. -M. , Jian, F. -F. , Zhao, P.-S. , Sun, X. -Z. & Lin, C. -H. (2007). Acta Cryst. E63, o2618–o2619. Kimura, T. , Kai, Y. , Yasuoka, N. & Kasai, N. (1977). Acta Cryst. B33, 1786– 1792. Lombardino, G. & Ottemes, I. G. (1981). J. Med. Chem. 24, 830–834. Manna, F. , Chimenti, F. , Bolasco, A. , Secci, D. , Bizzarri, B. , Befani, O. , Turini, P., Mondovi, B. , Alcaro, S. & Tafi, A. (2002). Bioorg. Med. Chem. Lett. 12, 3629–3635. Rawal, A. A. , Thakor, V. M. & Shah, N. M. (1963). J. Indian Chem. Soc. 40, 323–326. Sheldrick, G. M. (1997). SHELXL97 and SHELXS97. University of Göttingen, Germany. organic compounds
(SP-4-2)-(4,4′-Di-tert-butyl-2,2′-bipyridine-κ2N,N′)diiodidopalladium(II)

In the title compound, [PdI2(C18H24N2)], the coordination at the Pd atom is distorted square planar; the ligand bite is 79.19 (17)°. The compound is isotypic with the dichlorido analogue. The Pd—N bond lengths of 2.047 (4) and 2.062 (4)A are ca 0.03 A longer than those of the chloride derivative.
1-(Phenylsulfonyl)-2-[1-(phenylsulfonyl)-2-(3,4,5-trimethoxyphenyl)ethyl]indole

The title compound contains an indole ring system with two phenylsulfonyl groups and one 3,4,5-trimethoxyphenyl group as exocyclic substituents. The methoxy groups in the 3,4,5-trimethoxyphenyl moiety are twisted with respect to the plane of the ring. One of the phenylsulfonyl ring systems and the ring of the 3,4,5-trimethoxyphenyl group are nearly perpendicular to the indole ring system, while the other phenylsulfonyl ring system is inclined at an angle of 30° to it
Di‐μ‐thiocyanato‐κ4N:N‐bis({2‐[2‐(methylamino)ethyliminomethyl]phenolato}copper(II))

The asymmetric unit of the title compound, [Cu2(NCS)2(C10H13N2O)2], contains one-half of the centrosymmetric dinuclear complex, which exhibits a Cu⋯Cu separation of 3.255 (2) A. In the complex, each CuII ion is penta­coordinated in a square-pyramidal geometry. The basal plane is formed by one phenol O [Cu—O = 1.910 (4) A], one imine N [Cu—N = 1.922 (5) A] and one amine N [Cu—N = 2.041 (5) A] atoms from the Schiff base ligand, and by the N atom [Cu—N = 1.940 (6) A] from a thio­cyanate ligand. The apical position is occupied by the N atom [Cu—N = 2.768 (6) A] of another thio­cyanate ligand. There are intramolecular N—H⋯O hydrogen bonds linking the two ligands.
The equilibrium OH bond length

The equilibrium structure of 36 small molecules containing OH bonds, including molecules with an internal hydrogen bond, is reviewed from the literature. The structures are redetermined or determined, if necessary, using high level ab initio calculations at the CCSD(T) level of theory with basis sets of quintuple zeta quality and with a correction for the core correlation. The possibility of calculating accurate ab initio OH bond lengths at different levels of theory (MP2/VTZ, MP2/VQZ, CCSD(T)/VTZ, and CCSD(T)/AVTZ) is examined. All methods agree provided a small offset correction is taken into account. In most cases, the addition of diffuse functions does not improve the results. The MP2 method appears to be satisfactory whenever the non-dynamical electron correlation is small, which is the most typical situation. The various results are merged to demonstrate the following quantitative correlation between r e(OH) and ‘isolated’ OH stretching frequencies, relevant for predictive use: r e(OH) [Å] = 1.2261(76)–7.29(21) × 10−5 νis(OH) [cm−1].
5‐Bromo‐N′‐(2‐hydroxybenzylidene)nicotinohydrazide

The title Schiff base compound, C13H10BrN3O2, was derived from the condensation reaction of salicylaldehyde with 5-bromo­nicotinohydrazide. The dihedral angle between the benzene ring and the pyridine ring is 13.2 (4)°. In the crystal structure, mol­ecules are linked through N—H⋯O and C—H⋯O inter­molecular hydrogen bonds, forming chains running along the c axis.
CATALASA, PEROXIDASA Y POLIFENOLOXIDASA EN PITAYA AMARILLA (Acanthocereus pitajaya): MADURACIÓN Y SENESCENCIA

We evaluate the relation between some symptoms of deterioration and the activity of enzymes entailed with both the browning and the antioxiding system in fruits of yellow pitaya (Acanthocereus pitajaya), harvested in its physiological maturity and stored for 15 days at 24°C and 85% of relative humidity. In the whole fruits, the respiratory intensity and the external colors were evaluated; further, the activity of catalase (CAT), peroxidase (POD) and polyphenoloxidase (PPO) was studied in the peel of the fruit. The fruit exhibited a climacteric behavior six days after the date of the harvest. The browning of the peel had a direct relation with the activity of POD and PPO. The maximum observed activity of CAT in the climacterium, responds to the proper balance with the high production of H2O2 expected at that moment.
Anticonvulsant Therapy, Pharmacological Basis and Practice

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Dichlorido{2,4‐dibromo‐6‐[2‐(ethylammonio)ethyliminomethyl]phenolato}zinc(II)

In the title mononuclear zinc(II) complex, [ZnCl2(C11H14Br2N2O)], the Zn atom is four-coordinated by the imine N and the O atoms of the Schiff base ligand, and by two terminal chloride anions, forming a tetra­hedral geometry. In the crystal structure, mol­ecules are linked through inter­molecular N—H⋯Cl hydrogen bonds, forming a two-dimensional network.
Body Mass Index Percentile Curves for 7 To 18 Year Old Children and Adolescents; are the Sample Populations from Tehran Nationally Representative?

Background: The children's body composition status is an important indicator of health condition evaluated through their body mass index (BMI). We aimed to provide standardized percentile curves of BMI in a population of Iranian children and adolescents. We assessed the nationally representative of sample populations from Tehran. Materials and Methods: A total sample of 14,865 children aged 7-18 years was gathered. The Lambda-Mu-Sigma method was used to derive sex-specific smoothed centiles for age via the Lambda-Mu-Sigma Chart Maker Program. Finally, the prevalence of overweight and obesity with 95 confidence interval (CI) was calculated. Results: BMI percentiles obtained from Tehran's population, except for the 10thpercentile, seem to be very slightly greater than the urban boys from all over Iran. BMI percentiles have an increasing trend by age that is S-shaped with a slight slope. Only in the 90th and 97thpercentiles of BMI for girls, this rising trend seems to stop. Boys generally have higher BMIs than girls. The exceptions are younger ages of 90thand 97thpercentiles and older ages of 3rdand 10thpercentiles. A total number of 1,008 (13.20; 95 CI: 12.46-13.98) boys and 603 (8.34; 95 CI: 7.72-9.00) girls were categorized as overweight and obese. Obesity were observed in 402 (5.27; 95 CI: 4.79-5.79) boys and 274 (3.76; 95 CI: 3.35-4.22) girls. Conclusion: We construct BMI percentile curves by age and gender for 7 to 18 years Iranian children and adolescents. It can be concluded that sample populations from Tehran are nationally representative.
Insulin Initiation in Type 2 Diabetes – Why, When and How?

Abstract Type 2 diabetes is a progressive disease and, despite recent progress in the treatment of diabetes, the glycemic control usually deteriorates gradually and insulin therapy is needed. When insulin therapy should be started and which are the appropriate insulin therapy strategies, still represent subjects of debates. Insulin represents a therapeutic option in type 2 diabetes due to the existence of early β-cell dysfunction and significant reduction of β-cell mass in natural history of type 2 diabetes. The current guidelines recommend insulin in double therapy in association with metformin or in combination with metformin and other noninsulin agent. Initiation of insulin therapy is recommended in patients with newly diagnosed type 2 diabetes and symptomatic and/or presenting important hyperglycemia or elevated HbA1c. Initiation of insulin therapy in type 2 diabetes should take into consideration the pathophysiology of type 2 diabetes, the effects and the potential risks of insulin therapy, the guidelines recommendations and the barriers to insulin use. Literatures of only English language were analyzed from NCBI database. Guidelines were accessed electronically from organisations, i.e. American Diabetes Associations, American Association of Clinical Endocrinologists and American College of Endocrinology, European Association for the Study of Diabetes, International Diabetes Federation.
Dichlorido[N,N,N′,N′‐tetramethylcyclohexane‐1,2‐diamine‐κ2N,N′]zinc(II)

In the title compound, [ZnCl2(C10H22N2)], the ZnII ion coordinates to the N atoms of tetra­methyl­cyclo­hexane-1,2-diamine and to two chloride ions in an approximately tetra­hedral arrangement. The N—Zn—N and Cl—Zn—Cl planes are approximately orthogonal, with a dihedral angle of 89.7 (2)° between them. Four C atoms of the cyclohexane ring, together with their attached H atoms, are disordered equally over two sites.
1-(3-Chloro­benzo­yl)-3-(3-chloro­phen­yl)thio­urea

The chloro­phenyl and benzoyl groups in the title compound, C14H10Cl2N2OS, are cis and trans, respectively, with respect to the C=S bond. The crystal packing is characterized by N—H⋯O, N—H⋯S and N—H⋯Cl hydrogen bonds.
Practice and Barriers towards Pap Smear Test from a Public Hospital in Malaysia

Objective: The objective of this study was to determine the practice and barriers towards Pap smear test among Malaysian women from a public hospital in Selangor, Malaysia. Methodology: This study used a cross-sectional, descriptive design. A simple random sampling of 142 women aged 18 to 70 years was recruited from the waiting rooms of Obstetrics & Gynecology ambulatory at Tengku Ampuan Rahimah Hospital, Klang; Malaysia. This study was approved by the ethics committee of Management and Science University. The consent form was then given to the participant in order to get their permission to be part of this research. Self-administered questionnaire was distributed to the patients during their waiting hours. All participants were provided with a full explanation on the purpose of the study and how to fill the form. The data was analyzed using Statistical Package for Social Sciences (SPSS) version 13.0. ANOVA and t-test were used in univariate analysis. Multiple linear regression was also used in multivariate analysis. Results: A total number of 142 patients participated in this study; mean age was 31.55 years old (SD ± 8.17). The majority of the participants were younger than 35 years old, Malay, with family monthly income less than 3000 Ringgit Malaysia (1000U$) and single (62%, 68.3%, 64.1%, 88.7%; respectively). Regarding Pap smear Practice, 46.5% had at least one Pap smear in their lifetime. Several barriers were reported towards Pap smear test in this study; lack of knowledge was the main barrier among the participants. Age, marital status and knowledge has significantly influenced the practice of Pap smear test among women (p=0.001, p=0.001, p=0.001; respectively). Conclusion: This study showed very poor practice towards Pap smear test among study participants. Moreover lack of basic knowledge was the commonest barrier among the participants. Age, marital status and knowledge have significantly influenced the practice of Pap smear test among women. *Corresponding author: Redhwan Ahmed Al-Naggar, Community Medicine Department, International Medical School, Management and Science University, Malaysia, E-mail: radhwan888@yahoo.com Received February 22, 2012; Accepted March 17, 2012; Published March 19, 2012 Citation: Al-Naggar RA (2012) Practice and Barriers towards Pap Smear Test from a Public Hospital in Malaysia. J Community Med Health Edu 2:132. doi:10.4172/ jcmhe.1000132 Copyright: © 2012 Al-Naggar RA. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
2,2'‐Dibromobiphenyl

The title compound, C 12 H 8 Br 2 , crystallizes in the orthorhombic space group Pbca. The molecule displays non-planar behaviour and the dihedral angle between the two six-membered rings is 84.8(2)°. The bond length between the two phenyl rings (C1-C1') and the C-Br bond lengths (C2-Br1 and C2'-Br2) are 1.499 (9), 1.895 (8) and 1.915 (7) A, respectively.