Miracle-dz/UniFAR-FTUs huggingface dataset:
Examining Causes and Prevention Strategies of Adverse Events in Deceased Hospital Patients: A Retrospective Patient Record Review Study in the Netherlands.

OBJECTIVE To improve patient safety and possibly prevent mortality from adverse events (AEs) in hospitals, it is important to gain insight in their underlying causes. We aimed to examine root causes and potential prevention strategies of AEs in deceased hospital patients. METHODS Data on 571 AEs were used from two retrospective patient record review studies of patients who died during hospitalization in the Netherlands. Trained reviewers assessed contributing factors and potential prevention strategies. The results were analyzed together with data on preventability of the AE and the relationship of the AE with the death of the patient. RESULTS In 47% of the AEs, patient-related causes were identified, in 35% human causes, in 9% organizational causes, and in 3% technical causes. Preventable AEs were caused by technical, organizational, and human causes (78%, 74%, and 74%, respectively) more often than by patient-related causes (33%). In addition, technical factors caused AEs leading to preventable death (78%) relatively often. Recommended strategies to prevent AEs were quality assurance/peer review, evaluation of safety behavior, improving procedures, and improving information and communication structures. CONCLUSIONS Human failures played an important role in the causation of AEs in Dutch hospitals, because they occurred frequently and they were frequently the cause of preventable AEs. To a lesser extent, latent organizational and technical factors were identified. Patient-related factors were often identified, but the preventability of the AEs with these causes was low. For future research into causes of AEs, we recommend combining record review with interviewing.
Stellar mass as a galaxy cluster mass proxy: application to the Dark Energy Survey redMaPPer clusters

We introduce a galaxy cluster mass observable, μ⋆, based on the stellar masses of cluster members, and we present results for the Dark Energy Survey (DES) Year 1 (Y1) observations. Stellar masses are computed using a Bayesian model averaging method, and are validated for DES data using simulations and COSMOS data. We show that μ⋆ works as a promising mass proxy by comparing our predictions to X-ray measurements. We measure the X-ray temperature–μ⋆ relation for a total of 129 clusters matched between the wide-field DES Y1 redMaPPer catalogue and Chandra and XMM archival observations, spanning the redshift range 0.1 < $z$ < 0.7. For a scaling relation that is linear in logarithmic space, we find a slope of α = 0.488 ± 0.043 and a scatter in the X-ray temperature at fixed μ⋆ of $\sigma _{{\rm ln} T_\mathrm{ X}|\mu _\star }= 0.266^{+0.019}_{-0.020}$ for the joint sample. By using the halo mass scaling relations of the X-ray temperature from the Weighing the Giants program, we further derive the μ⋆-conditioned scatter in mass, finding $\sigma _{{\rm ln} M|\mu _\star }= 0.26^{+ 0.15}_{- 0.10}$. These results are competitive with well-established cluster mass proxies used for cosmological analyses, showing that μ⋆ can be used as a reliable and physically motivated mass proxy to derive cosmological constraints.
Amphiphysin 2 modulation rescues myotubular myopathy and prevents focal adhesion defects in mice

Modulation of human amphiphysin 2 expression by genetic cross and viral delivery rescues all hallmarks of X-linked centronuclear myopathy in mice. A muscle-building interaction Centronuclear myopathies (CNMs) are rare genetic disorders characterized by severe muscle weakness. Mutations in myotubularin 1 (MTM1) and in amphiphysin 2 (BIN1) are responsible for two different forms of the disease. BIN1 and MTM1 have been shown to interact in skeletal muscles. Now, Lionello et al. investigated the role of this interaction in a model of Mtm1-mediated CNM. Postnatal BIN1 overexpression improved survival and muscle strength in Mtm1 knockout mice. The treatment also restored myofiber integrity and rescued extracellular matrix and focal adhesion defects in myofibers. The results suggest that BIN1-MTM1 interaction plays a role in CNM and could be targeted for treating CNM due to MTM1 mutations. Centronuclear myopathies (CNMs) are severe diseases characterized by muscle weakness and myofiber atrophy. Currently, there are no approved treatments for these disorders. Mutations in the phosphoinositide 3-phosphatase myotubularin (MTM1) are responsible for X-linked CNM (XLCNM), also called myotubular myopathy, whereas mutations in the membrane remodeling Bin/amphiphysin/Rvs protein amphiphysin 2 [bridging integrator 1 (BIN1)] are responsible for an autosomal form of the disease. Here, we investigated the functional relationship between MTM1 and BIN1 in healthy skeletal muscle and in the physiopathology of CNM. Genetic overexpression of human BIN1 efficiently rescued the muscle weakness and life span in a mouse model of XLCNM. Exogenous human BIN1 expression with adeno-associated virus after birth also prevented the progression of the disease, suggesting that human BIN1 overexpression can compensate for the lack of MTM1 expression in this mouse model. Our results showed that MTM1 controls cell adhesion and integrin localization in mammalian muscle. Alterations in this pathway in Mtm1−/y mice were associated with defects in myofiber shape and size. BIN1 expression rescued integrin and laminin alterations and restored myofiber integrity, supporting the idea that MTM1 and BIN1 are functionally linked and necessary for focal adhesions in skeletal muscle. The results suggest that BIN1 modulation might be an effective strategy for treating XLCNM.
Essential tori in spaces of symplectic embeddings

Given two $2n$--dimensional symplectic ellipsoids whose symplectic sizes satisfy certain inequalities, we show that a certain map from the $n$--torus to the space of symplectic embeddings from one ellipsoid to the other induces an injective map on singular homology with mod $2$ coefficients. The proof uses parametrized moduli spaces of $J$--holomorphic cylinders in completed symplectic cobordisms.
Needs, strain, coping, and mental health among caregivers of individuals with autism spectrum disorder: A moderated mediation analysis

This study investigated the relationships among caregiving strain, coping, and mental health among caregivers of individuals with autism spectrum disorder (ASD) and the mediational moderation of caregiver needs. One hundred and ninety-three caregivers of individuals with ASD completed an online survey. Results showed that maladaptive coping behaviors were significant in mediating the relationship between strain and mental health. Professional service and emotional caregiving needs moderated the relationship between maladaptive coping and mental health at times of high caregiving strain, but not involvement, health information, and instrumental support needs. Results highlighted the negative effect of maladaptive coping, as well as professional service and emotional support needs were salient in moderating coping and mental health in times of high caregiving strain.
Salt tectonics in a double salt‐source layer setting (Eastern Persian Gulf, Iran): Insights from interpretation of seismic profiles and sequential cross‐section restoration

Salt tectonics in the Eastern Persian Gulf (Iran) is linked to a unique salt‐bearing system involving two overlapping ‘autochthonous’ mobile source layers, the Ediacaran–Early Cambrian Hormuz Salt and the Late Oligocene–Early Miocene Fars Salt. Interpretations of reflection seismic profiles and sequential cross‐section restorations are presented to decipher the evolution of salt structures from the two source layers and their kinematic interaction on the style of salt flow. Seismic interpretations illustrate that the Hormuz and Fars salts started flowing in the Early Palaeozoic (likely Cambrian) and Early Miocene, respectively, shortly after their deposition. Differential sedimentary loading (downbuilding) and subsalt basement faults initiated and localized the flow of the Hormuz Salt and the related salt structures. The resultant diapirs grew by passive diapirism until Late Cretaceous, whereas the pillows became inactive during the Mesozoic after a progressive decline of growth in the Late Palaeozoic. The diapirs and pillows were then subjected to a Palaeocene–Eocene contractional deformation event, which squeezed the diapirs. The consequence was significant salt extrusion, leading to the development of allochthonous salt sheets and wings. Subsequent rise of the Hormuz Salt occurred in wider salt stocks and secondary salt walls by coeval passive diapirism and tectonic shortening since Late Oligocene. Evacuation and diapirism of the Fars Salt was driven mainly by differential sedimentary loading in annular and elongate minibasins overlying the salt and locally by downslope gliding around pre‐existing stocks of the Hormuz Salt. At earlier stages, the Fars Salt flowed not only towards the pre‐existing Hormuz stocks but also away from them to initiate ring‐like salt walls and anticlines around some of the stocks. Subsequently, once primary welds developed around these stocks, the Fars Salt flowed outwards to source the peripheral salt walls. Our results reveal that evolving pre‐existing salt structures from an older source layer have triggered the flow of a younger salt layer and controlled the resulting salt structures. This interaction complicates the flow direction of the younger salt layer, the geometry and spatial distribution of its structures, as well as minibasin depocentre migration through time. Even though dealing with a unique case of two ‘autochthonous’ mobile salt layers, this work may also provide constraints on our understanding of the kinematics of salt flow and diapirism in other salt basins having significant ‘allochthonous’ salt that is coevally affected by deformation of the deeper autochthonous salt layer and related structures.
Derivation of multidimensional stochastic Cramer‐Rao bound for mixture of noncoherent and coherent near/far field signals

The existing Cramer‐Rao bound (CRB) expressions in the literature are not applicable to the problem of localization of mixed near‐field (NF) and far‐field (FF) sources, including noncoherent and coherent signals, using two‐dimensional arrays. Given the unique properties of circular arrays, in this article, the mathematical model of received signals in multipath environments, including a mixture of noncoherent and coherent NF/FF signals, is introduced. Then, the stochastic CRBs associated with the above problem are derived. The compact closed‐form expression of CRB extracted in this article can be used for the algorithms under the above scenario as a benchmark to evaluate the estimation accuracy of azimuth DOA, elevation DOA, and range parameters as well as fading coefficient parameter. The simulation results show that the CRBs of the azimuth DOAs, elevation DOAs, ranges, and FCs decrease, on average, at a rate of approximately O(M−1.9), O(M−1.9), O(M−1.2), and O(M−1.8) as M (number of sensors) goes to infinity, respectively, where O is the notation of the asymptotic growth rate.
Asymmetric relationship of investor sentiment with stock return and volatility: evidence from India

PurposeThe study examines the cross-sectional and asymmetric relationship of investor sentiment with the stock returns and volatility in India.Design/methodology/approachThe investor sentiment is captured using a market-based measure Market Mood Index (MMI) and a survey-based measure Consumer Sentiment Index (CSI). The asymmetric effect of the relationship is examined using quantile causality approach and cross-sectional effect is examined by considering indices such as the BSE Sensex, and the various size indices such as BSE Large cap, BSE Mid cap and BSE Small cap.FindingsThe result of the study found that investor sentiment (MMI) cause stock returns at extreme quantiles. Lower sentiment induces fear-induced selling, thereby lowers the returns and high sentiment is followed by lower future returns as market reverts to fundamentals. On the other hand, bullish shifts in sentiment lower the volatility. There exists a positive feedback effect of stock return and volatility in the formation of investor sentiment.Originality/valueThe study captures both asymmetric and cross-sectional relationship of investor sentiment and stock market in an emerging economy, India. The study uses a novel data set (i.e.) MMI which captures the sentiment based on market indicators and are widely disseminated to the public.
Black holes with surrounding matter and rainbow scattering

The scattering of light by water droplets can produce one of the most beautiful phenomena in Nature: the rainbow. This optical phenomenon has analogues in molecular, atomic and nuclear physics. Recently, rainbow scattering has been shown to arise from the gravitational interaction of a scalar field with a compact horizonless object. We show that rainbow scattering can also occur in the background of a black hole with surrounding matter. We study the scattering of null geodesics and planar massless scalar waves by Schwarzschild black holes surrounded by a thin spherical shell of matter. We explore various configurations of this system, analyzing changes in mass fraction and radius of the shell. We show that the deflection function can present stationary points, what leads to rainbow scattering. We analyze the large-angle scattered amplitude as a function of the shell's parameters, showing that it presents a non-monotonic behavior.
Clinical Assessment of 2 Licensed AbobotulinumtoxinA Injection Volumes for the Treatment of Glabellar Lines.

BACKGROUND Two licensed reconstitution volumes may be used to achieve the recommended abobotulinumtoxinA (ABO) dose for glabellar line correction. OBJECTIVE Comparison of efficacy, safety, and subject satisfaction concerning treatment of moderate to severe glabellar lines with 2 different ABO reconstitution volumes. MATERIALS AND METHODS Phase IV, prospective, randomized, multicenter, subject- and evaluator-blinded study: 60 subjects received 1 ABO (50 units) treatment, administered as a 1.5- or 2.5-mL reconstitution. Primary objective was Day 30 improvements (≥1-point) in glabellar line severity. Onset of effect, duration, subject satisfaction, and treatment-related adverse events (AEs) were assessed. RESULTS At Day 30, 90.0% and 86.7% of subjects achieved ≥1-point improvements with 1.5- and 2.5-mL reconstitutions, respectively. Median time to onset of effect was 48 hours after treatment. At 24 hours, 26.7% achieved ≥1-point improvements with the 2.5-mL reconstitution versus 6.7% with the 1.5-mL reconstitution. Maximum response was at Day 14, and >40% maintained efficacy through Day 120 in each group. High subject satisfaction was sustained throughout observation. Most AEs were mild. No serious AEs were reported. CONCLUSION Both ABO reconstitutions were well tolerated and effective in correcting glabellar lines with no significant differences concerning efficacy or duration of effect. No serious AEs were reported.
Characterising the diversity of grain nutritional and physico-chemical quality in Indian rice landraces by multivariate genetic analyses

We evaluated a set of 190 genotypes for five grain-nutrient, five grain physico-chemical quality and four derived traits. Wide variability was observed for all the traits studied, with CV ranging from 9.33 to 51.89%. No correlation was observed between grain nutritional and physico-chemical quality traits. Iron (Fe) and Zinc (Zn) content in brown rice showed significant positive correlation. Zn content in brown and polished rice showed significant association however, the Fe content in brown and polished rice did not show significant association. Two principal components each in grain nutritional and physico-chemical traits explained 73.15 % and 62.82 % of the total variation, respectively. Cluster analysis grouped the accessions into two and three clusters on the basis of grain physico-chemical traits and nutritional traits, respectively. The study has led to the identification of promising donors for biofortification and grain quality improvement in rice.
Positivity Effect and Working Memory Performance Remains Intact in Older Adults After Sleep Deprivation

Background: Older adults perform better in tasks which include positive stimuli, referred to as the positivity effect. However, recent research suggests that the positivity effect could be attenuated when additional challenges such as stress or cognitive demands are introduced. Moreover, it is well established that older adults are relatively resilient to many of the adverse effects of sleep deprivation. Our aim was to investigate if the positivity effect in older adults is affected by one night of total sleep deprivation using an emotional working memory task. Methods: A healthy sample of 48 older adults (60-72 years) was either sleep deprived for one night (n = 24) or had a normal night’s sleep (n = 24). They performed an emotional working memory n-back (n = 1 and 3) task containing positive, negative and neutral pictures. Results: Performance in terms of accuracy and reaction times was best for positive stimuli and worst for negative stimuli. This positivity effect was not altered by sleep deprivation. Results also showed that, despite significantly increased sleepiness, there was no effect of sleep deprivation on working memory performance. A working memory load × valence interaction on the reaction times revealed that the beneficial effect of positive stimuli was only present in the 1-back condition. Conclusion: While the positivity effect and general working memory abilities in older adults are intact after one night of sleep deprivation, increased cognitive demand attenuates the positivity effect on working memory speed.
Early goal-directed haemodynamic optimization of cerebral oxygenation in comatose survivors after cardiac arrest: the Neuroprotect post-cardiac arrest trial.

AIMS During the first 6-12 h of intensive care unit (ICU) stay, post-cardiac arrest (CA) patients treated with a mean arterial pressure (MAP) 65 mmHg target experience a drop of the cerebral oxygenation that may cause additional cerebral damage. Therefore, we investigated whether an early goal directed haemodynamic optimization strategy (EGDHO) (MAP 85-100 mmHg, SVO2 65-75%) is safe and could improve cerebral oxygenation, reduce anoxic brain damage, and improve outcome when compared with a MAP 65 mmHg strategy. METHODS AND RESULTS A total of 112 out-of-hospital CA patients were randomly assigned to EGDHO or MAP 65 mmHg strategies during the first 36 h of ICU stay. The primary outcome was the extent of anoxic brain damage as quantified by the percentage of voxels below an apparent diffusion coefficient (ADC) score of 650.10-6 mm2/s on diffusion weighted magnetic resonance imaging (at day 5 ± 2 post-CA). Main secondary outcome was favourable neurological outcome (CPC score 1-2) at 180 days. In patients assigned to EGDHO, MAP (P < 0.001), and cerebral oxygenation during the first 12 h of ICU stay (P = 0.04) were higher. However, the percentage of voxels below an ADC score of 650.10-6 mm2/s did not differ between both groups [16% vs. 12%, odds ratio 1.37, 95% confidence interval (CI) 0.95-0.98; P = 0.09]. Also, the number of patients with favourable neurological outcome at 180 days was similar (40% vs. 38%, odds ratio 0.98, 95% CI 0.41-2.33; P = 0.96). The number of serious adverse events was lower in patients assigned to EGDHO (P = 0.02). CONCLUSION Targeting a higher MAP in post-CA patients was safe and improved cerebral oxygenation but did not improve the extent of anoxic brain damage or neurological outcome.
Effect of MSCs and MSC-Derived Extracellular Vesicles on Human Blood Coagulation

Mesenchymal stem cells (MSCs) have emerged as a potent therapeutic tool for the treatment of a number of pathologies, including immune pathologies. However, unwelcome effects of MSCs on blood coagulation have been reported, motivating us to explore the thrombotic properties of human MSCs from the umbilical cord. We revealed strong procoagulant effects of MSCs on human blood and platelet-free plasma using rotational thromboelastometry and thrombodynamic tests. A similar potentiation of clotting was demonstrated for MSC-derived extracellular vesicles (EVs). To offer approaches to avoid unwanted effects, we studied the impact of a heparin supplement on MSC procoagulative properties. However, MSCs still retained procoagulant activity toward blood from children receiving a therapeutic dose of unfractionated heparin. An analysis of the mechanisms responsible for the procoagulant effect of MSCs/EVs revealed the presence of tissue factor and other proteins involved in coagulation-associated pathways. Also, we found that some MSCs and EVs were positive for annexin V, which implies the presence of phosphatidylserine on their surfaces, which can potentiate clot formation. Thus, we revealed procoagulant activity of MSCs/EVs associated with the presence of phosphatidylserine and tissue factor, which requires further analysis to avoid adverse effects of MSC therapy in patients with a risk of thrombosis.
Maternal mitochondrial inheritance in two Fusarium pathogens of prickly ash (Zanthoxylum bungeanum) in northern China

ABSTRACT Mitochondrial inheritance in Fusarium zanthoxyli and F. continuum, two canker-inducing pathogens of prickly ash (Zanthoxylum bungeanum) in northern China, was investigated by genotyping ascospore progeny obtained from laboratory crosses. Polymorphic regions of the mitochondrial genomes (mitogenomes) that contained indels and single-nucleotide polymorphisms (SNPs) were identified via comparative analyses of the complete mitogenomes of the parents used in the intraspecific crosses. A reciprocal genetic cross of F. zanthoxyli NRRL 66714 × NRRL 66285, and a separate cross of F. continuum ♀ NRRL 66286 × ♂ NRRL 66218, revealed that mitochondria were only inherited from the maternal parent. In addition, the reciprocal cross demonstrated that mitochondrial inheritance is not linked to mating type. Gene order in the circular mitogenomes of the prickly ash pathogens was identical to that previously reported for other fusaria and members of the Hypocreales, except that the TRNL tRNAs were duplicated in F. zanthoxyli NRRL 66714. The genomes contained 14 polypeptide-encoding genes involved in oxidative respiration, one intron-encoded ribosomal protein (rps3) gene, two ribosomal RNA (rRNA) genes, and 26–28 tRNA genes. The F. zanthoxyli mitogenomes were 80.9 and 98.7 kb in length, whereas those of F. continuum were considerably shorter and nearly identical in length at 63.4 kb. The significant differences in mitogenome length were primarily due to variable numbers of introns and open reading frames (ORFs) encoding hypothetical proteins.
Difference in Treatment Effect Between Intravitreal Aflibercept Injection and Laser by Baseline Factors in Diabetic Macular Edema.

BACKGROUND AND OBJECTIVE To evaluate the effect of baseline factors on differences in vision gains with intravitreal aflibercept injection (IAI) versus laser control in patients with diabetic macular edema (DME). PATIENTS AND METHODS This was an integrated post-hoc subanalysis of two phase 3 trials (VISTA, VIVID) in patients with DME. Least square (LS) mean differences of patients treated with IAI compared to laser control in best-corrected visual acuity (BCVA) change from baseline at week 100 were evaluated for association with baseline demographics and baseline systemic disease characteristics. RESULTS At week 100, LS mean differences in BCVA change from baseline with IAI compared to laser control were not significant for association with baseline age, gender, and race or status of glycosylated hemoglobin, body mass index, renal impairment, hypertension, cerebrovascular disease, and ischemic heart disease. CONCLUSION Vision gains with IAI were significantly greater than laser control and were not influenced by demographics and systemic disease control at baseline. [Ophthalmic Surg Lasers Imaging Retina. 2019;50:167-173. ].