Miracle-dz/UniFAR-FTUs huggingface dataset:
Psychoform and somatoform dissociation in anorexia nervosa: a systematic review.

Dissociation is a debilitating condition often present as comorbidity in patients with eating disorders but to date only mixed data are available. Additionally, very little data exist on the classification of dissociation, namely psychoform and somatoform, in anorexia nervosa (AN). This review aimed to provide an updated view on the literature about dissociation in AN, with a focus on AN subtypes (i.e., restricter and binge-purging) as well as dissociation type (i.e., psychoform and somatoform), when available. We screened 304 studies and, after title and abstract selection and full-text reading, 29 of them were included in the review. Most of the studies investigated psychoform dissociation, while just 4 publications considered somatoform dissociation. Dissociation resulted to be present in AN more than in healthy controls and in individuals with other psychiatric disorders, and it was related mostly to the binge-purging subtype of AN. Moreover, dissociation was linked with traumatic events, self-harm, and negative treatment outcomes, especially in patients affected by the binge-purging subtype of AN. However, results on these topics are scarce and partially discordant. The methodological assessment we performed revealed an overall fair quality of the included studies, although several flaws emerged as well. The present review reported on one hand the relevance of dissociation in AN, but on the other hand the need to stimulate the scientific debate on a) a deeper investigation of somatoform dissociation in AN, and b) the relationship between dissociation and both clinical severity and treatment response/resistance in AN.
Observations on the Sand Dunes of Barbados, British West Indies

The island of Barbados is small and very fully cultivated. By far the greater part of the original flora has been destroyed or changed beyond recognition by the hand of man, and, for this reason, perhaps, there has been little written about the botany of the island. Thus, although the following account of the plant life of the sand dunes of Barbados is chiefly concerned with their floristic aspect, and a great deal of work remains to be done to substantiate the rather tentative conclusions drawn, it is felt that these observations are worthy of record.
Relationship quality and mental health during COVID-19 lockdown

Catastrophes are known to have an impact on relationships as well as on mental health. This study evaluated differences in several mental health and well-being measures according to relationship quality during the Coronavirus Disease (COVID-19) pandemic and related lockdown measures. A cross-sectional online survey was launched four weeks after lockdown measures were implemented in Austria. Relationship quality was measured with the Quality of Marriage Index (QMI), and mental health measures included quality of life (WHO-QOL BREF psychological domain), well-being (WHO-5), depression (PHQ-9), anxiety (GAD-7), stress (PSS-10), and sleep quality (ISI). ANOVAs with Bonferroni-corrected post-hoc tests and Chisquared tests were applied. In all mental health scales, individuals with good relationship quality (n = 543) scored better than individuals with poor relationship quality (n = 190) or without relationship (n = 272). The odds ratios (OR) between the poor and good relationship quality groups were 3.5 for the PHQ-9, 3.4 for the GAD-7, and 2.0 for the ISI. Additionally, individuals without no relationship scored better on all scales than individuals with poor relationship quality (all p-values < .05). Relationship quality was related to mental health during COVID-19. The prevalence of depressive symptoms increased according to relationship quality from 13% up to 35%. Relationship per se was not associated with better mental health, but the quality of the relationship was essential. Compared to no relationship, a good relationship quality was a protective factor whereas a poor relationship quality was a risk factor.
Do final-year medical students have sufficient knowledge of pain management?

BACKGROUND The prevalence of pain is high and there have also been serious complications related to undermanaged pain. Deficiency in pain education is among the causes of the problem. Studies in the last two decades have consistently reported that knowledge and attitude regarding pain management was generally poor among the medical students. The aim of this study is to assess the knowledge and attitudes among the Universiti Malaysia Sarawak (UNIAMS) final year medical students regarding pain management. METHODS This is a cross-sectional study and "Knowledge and Attitudes Survey Regarding Pain (KASRP)" questionnaire developed by Ferrell and McCaffery (revised in 2014) was used. Data was collected in July 2019 in which students had to complete the hard copy questionnaire before a teaching session began. Participation of students was voluntary, anonymous and written informed consent was also obtained. Data were analysed using SPSS, version 16. RESULTS Out of 118 enrolled students, 110 participated in this study giving a response rate of 93%. The results showed a low number of correct response to the questions on analgesics, assessment, and treatment. The mean percentage score of correct answers was 52.23±8.67% (range: 29.27% to 70.73%). The results reflected that students were poor in both knowledge and attitude regarding pain management. CONCLUSION Final year medical students, frontliners-to-be in hospital care, should have good knowledge and attitudes in pain management. Findings, however, revealed that UNIMAS final year medical students still need to get improved in this aspect of patient care. A larger study involving students from all the medical schools in Malaysia is needed before reviewing the undergraduate curriculum for pain.
Unpaired Training of Deep Learning tMRA for Flexible Spatio-Temporal Resolution

Time-resolved MR angiography (tMRA) has been widely used for dynamic contrast enhanced MRI (DCE-MRI) due to its highly accelerated acquisition. In tMRA, the periphery of the ${\textit k}$ -space data are sparsely sampled so that neighbouring frames can be merged to construct one temporal frame. However, this view-sharing scheme fundamentally limits the temporal resolution, and it is not possible to change the view-sharing number to achieve different spatio-temporal resolution trade-offs. Although many deep learning approaches have been recently proposed for MR reconstruction from sparse samples, the existing approaches usually require matched fully sampled ${\textit k}$ -space reference data for supervised training, which is not suitable for tMRA due to the lack of high spatio-temporal resolution ground-truth images. To address this problem, here we propose a novel unpaired training scheme for deep learning using optimal transport driven cycle-consistent generative adversarial network (cycleGAN). In contrast to the conventional cycleGAN with two pairs of generator and discriminator, the new architecture requires just a single pair of generator and discriminator, which makes the training much simpler but still improves the performance. Reconstruction results using in vivo tMRA and simulation data set confirm that the proposed method can immediately generate high quality reconstruction results at various choices of view-sharing numbers, allowing us to exploit better trade-off between spatial and temporal resolution in time-resolved MR angiography.
Supermagnetic Sugarcane Bagasse Hydrochar for Enhanced Osteoconduction in Human Adipose Tissue-Derived Mesenchymal Stem Cells

Hydrothermally carbonized sugarcane bagasse (SCB) has exceptional surface properties. Looking at the huge amount of SCB produced, its biocompatible nature, cheap-cost for carbonization, and its easy functionalization can give impeccable nano-biomaterials for tissue engineering applications. Herein, sugarcane bagasse was converted into hydrochar (SCB-H) by hydrothermal carbonation. The SCB-H produced was further modified with iron oxide (Fe3O4) nanoparticles (denoted as SCB-H@Fe3O4). Facile synthesized nano-bio-composites were characterized by SEM, HR-TEM, XRD, FT-IR, XPS, TGA, and VSM analysis. Bare Fe3O4 nanoparticles (NPs), SCB-H, and SCB-H@Fe3O4 were tested for cytocompatibility and osteoconduction enhancement of human adipose tissue-derived mesenchymal stem cells (hADMSCs). The results confirmed the cytocompatible and nontoxic nature of SCB-H@Fe3O4. SCB-H did not show enhancement in osteoconduction, whilst on the other hand, Fe3O4 NPs exhibited a 0.5-fold increase in the osteoconduction of hADMSCs. However, SCB-H@Fe3O4 demonstrated an excellent enhancement in osteoconduction of a 3-fold increase over the control, and a 2.5-fold increase over the bare Fe3O4 NPs. Correspondingly, the expression patterns assessment of osteoconduction marker genes (ALP, OCN, and RUNX2) confirmed the osteoconductive enhancement by SCB-H@Fe3O4. In the proposed mechanism, the surface of SCB-H@Fe3O4 might provide a unique topology, and anchoring to receptors of hADMSCs leads to accelerated osteogenesis. In conclusion, agriculture waste-derived sustainable materials like “SCB-H@Fe3O44” can be potentially applied in highly valued medicinal applications of stem cell differentiation.
Association between serum ficolin-1 level and disease progression in primary biliary cholangitis

Pattern recognition molecules (PRMs) in the complement system contribute to homeostasis as mediators of complement activation. The contribution of PRMs to primary biliary cholangitis (PBC) is unknown. In the current study, we aimed to assess the association between PRMs and the clinical findings of PBC. A total of 122 PBC patients and 20 healthy controls were enrolled. We measured four different PRMs (mannose-binding lectin [MBL], ficolin-1, ficolin-2 and ficolin-3) using stored sera, and retrospectively analyzed the associations between PRMs and laboratory findings, histological findings, and the development of cirrhosis-related conditions. Ficolin-1 levels were significantly higher in the PBC patients than in the healthy controls (152 ng/mL vs 102 ng/mL, P = 0.034), but no significant differences were observed regarding MBL, ficolin-2, and ficolin-3 levels. Ficolin-1 was significantly correlated with alkaline phosphatase (ALP). Low ficolin-1 levels were significantly associated with the development of cirrhosis-related conditions independent for histological stage and ALP levels (hazard ratio: 0.933; 95% confidence interval: 0.875–0.994; P = 0.032). Patients with low levels of ficolin-1 (< 77 ng/mL) had a significantly increased rate of developing cirrhosis-related conditions. Low ficolin-1 levels were associated with disease progression independent of histological stage and ALP levels in patients with PBC.
Effect of herbal antibacterial extracts on the gut floral changes in Indian white shrimp Fenneropenaeus indicus.

Antibacterial methanolic extracts of Murraya koeniji, Psoralea corylifolia and Quercus infectoria were screened against the bacterial pathogens such as Pseudomonas aeruginosa, Staphylococcus aureus and Vibrio harveyi isolated from infected shrimp. Minimum Inhibitory Concentration (MIC) and Minimal Bacterial Concentration (MBC) were carried out against V. harveyi with three extracts and three different diets were prepared by supplementing equal proportion of the active fractions, namely Control (0), HD1 (500), HD2 (1000 mg/Kg). Diets were individually fed to the Fenneropenaeus indicus adults for 30 days. The survival, growth and bacterial resistance differed significantly (P<0.05) from the control group to experimental groups. Gut bacterial flora was analyzed qualitatively, quantitatively before and after feeding the herbal diets. The bacterial isolates of shrimp gut predominantly consisted of Aeromonas Sp; Photobacterium Sp; Proteus Sp; E.coli ; Salmonella Sp; Vibrio Sp and Yersinia Sp. After herbal diet treatment, gut floral changes were observed due to the antibacterial effects. The active principles of the herbal extracts suppressed the bacterial gut flora such as Salmonella sp. , Proteus sp. , Yersinia sp. and Aeromonas sp. , etc.
Contact is not enough: a qualitative study of how space and place impact on interprofessional education

ABSTRACT Interprofessional education (IPE) aims to prepare health-care students to provide patient care in a collaborative team environment. However, much health-care education is delivered in places and spaces which do not support interprofessional interaction. To examine the consequences of this, we explored how a relatively new health-care education center (the “space” and “place”) impacted interprofessional learning. This qualitative study drew on two data sources. Documents (n = 50) related to building design and curricula plans, and focus groups with medical and physician associate students co-learning within the building to explore their experiences of the building in relation to IPE (17 participants). Data coding and analysis were inductive, using thematic analysis. A key objective for the building was to support IPE. This objective was not translated into operational detail in later documents or into practice, as indicated by student experiences. Students experienced tensions and isolation from each other and other health-care students because of the building’s place (i.e. separate from other health-care programs), the learning space within the building, and the interplay between the space and timetables. This empirical study suggests that space and place can impact on interprofessional learning, emphasizing the importance of clearly conceptualizing educational spaces and places to underpin successful IPE.
Patterns of Urinary Neutrophil Gelatinase-Associated Lipocalin and Acute Kidney Injury in Neonates Receiving Cardiopulmonary Bypass

Elevated urinary neutrophil gelatinase-associated lipocalin (uNGAL) predicts acute kidney injury (AKI) in children following cardiopulmonary bypass (CPB) during cardiac surgery, but little is known about uNGAL’s predictive ability in neonates in this setting. We sought to determine the relationship between AKI and post-CPB uNGAL in neonates in the first 72 post-operative hours. Methods: Urine samples for uNGAL analysis were collected at preoperative baseline and serially post-operatively from 76 neonates undergoing CPB. Mixed-effects regression models and logistic models assessed associations between uNGAL and AKI (controlling for sex, gestational age, CPB time, surgical complexity, and age at surgery). Receiver-operator curves were applied to define optimal uNGAL cut-off values for AKI diagnosis. Results: Between 0 and 4 h post-operatively, uNGAL values did not differ between neonates with and without AKI. After 4 h until 16 h post-operatively, significant time-wise separation occurred between uNGAL values of neonates with AKI and those without AKI. Odds ratios at each time point significantly exceeded unity, peaking at 10 h post-operatively (3.48 (1.58, 8.71)). Between 4 and 16 h post-operatively, uNGAL discriminated AKI from no-AKI, with a sensitivity of 0.63 (0.49, 0.75) and a specificity of 0.68 (0.62, 0.74) at a cut-off value of 100 ng/mL. Conclusion: After 4 h until 16 h post-operatively, elevated uNGAL is associated with AKI in neonates receiving CPB during cardiac surgery; however, this relationship is more complex than in older children.
Enhancing feelings of security: How institutional trust promotes interpersonal trust

Interpersonal trust is an important source of social and economic development. Over decades, researchers debated the question whether and how public institutions influence interpersonal trust, making this relationship a much-discussed issue for scientific debate. However, experimental and behavioral data and insights on this relationship and the underlying psychological processes are rare and often inconsistent. The present set of studies tests a model which proposes that institutional trust indirectly affects trust among unrelated strangers by enhancing individuals’ feelings of security. Study 1 (survey on trust in a broad spectrum of state institutions), Study 2 (nationally representative data from 16 countries), and Study 3 (experimental manipulation of institutional trust) provide convergent support for this hypothesis. Also, the results show that the effect remains consistent even after controlling for individual dispositions linked to interpersonal and institutional trust (Study 1 and 3) and country level indicators of institutional performance (Study 2). Taken together, these findings inform and contribute to the debate about the relationship between institutions and interpersonal trust by showing that when institutions are trusted, they increase feelings of security, and therefore promote interpersonal trust among strangers.
Infectious Diseases Society of America Guidelines on the Diagnosis of COVID-19:Serologic Testing

Abstract Background The availability of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) serologic testing has rapidly increased. Current assays use a variety of technologies, measure different classes of immunoglobulin or immunoglobulin combinations and detect antibodies directed against different portions of the virus. The overall accuracy of these tests, however, has not been well-defined. The Infectious Diseases Society of America (IDSA) convened an expert panel to perform a systematic review of the coronavirus disease 2019 (COVID-19) serology literature and construct best practice guidance related to SARS-CoV-2 serologic testing. This guideline is the fourth in a series of rapid, frequently updated COVID-19 guidelines developed by IDSA. Objective IDSA’s goal was to develop evidence-based recommendations that assist clinicians, clinical laboratories, patients and policymakers in decisions related to the optimal use of SARS-CoV-2 serologic tests in a variety of settings. We also highlight important unmet research needs pertaining to the use of anti-SARS-CoV-2 antibody tests for diagnosis, public health surveillance, vaccine development and the selection of convalescent plasma donors. Methods A multidisciplinary panel of infectious diseases clinicians, clinical microbiologists and experts in systematic literature review identified and prioritized clinical questions related to the use of SARS-CoV-2 serologic tests. Grading of Recommendations Assessment, Development and Evaluation (GRADE) methodology was used to assess the certainty of evidence and make testing recommendations. Results The panel agreed on eight diagnostic recommendations. Conclusions Information on the clinical performance and utility of SARS-CoV-2 serologic tests are rapidly emerging. Based on available evidence, detection of anti-SARS-CoV-2 antibodies may be useful for confirming the presence of current or past infection in selected situations. The panel identified three potential indications for serologic testing including: 1) evaluation of patients with a high clinical suspicion for COVID-19 when molecular diagnostic testing is negative and at least two weeks have passed since symptom onset; 2) assessment of multisystem inflammatory syndrome in children; and 3) for conducting serosurveillance studies. The certainty of available evidence supporting the use of serology for either diagnosis or epidemiology was, however, graded as very low to moderate.
Habitual Aerobic Exercise Diminishes the Effects of Sarcopenia in Senescence-Accelerated Mice Prone8 Model

Loss of muscle mass and strength are progressing with aging. Exercise is a beneficial method to prevent physical dysfunction, and habitual exercise can improve the muscle quality. Therefore, we evaluated the effects of long-term habitual exercise’s impact on sarcopenia utilizing the senescence-accelerated mice prone8 (SAMP8) model. Notably, 27 w SAMP8 were used in this study. Mice were classified into 28 (28 w) and 44 weeks old. The 44-week group was divided into the sedentary group (44 w) and a group exercising for 16 weeks (44 w + Ex). The 44 w + Ex performed habitual exercise from 28 to 44 weeks. Additionally, grip strength tests were performed with mice aged 28 and 44 weeks. Muscles were harvested and measured muscle weight at 44 w. Gastrocnemius decreased in 44 w, but was unchanged in 44 w + Ex. There was a trend for lower muscle grip strength in the 44 w group, but there was no change in 44 w + Ex. The phosphorylation levels of Akt and p70S6K as a protein synthesis marker were decreased in 44 w. Cytochrome c oxidase subunit IV (CoxIV) mRNA and protein levels decreased in 44 w. These results suggested that long-term habitual exercise attenuates muscle mass and strength decline, possibly through maintenance of muscle protein synthesis and mitochondrial maintenance.
Patients on the psychosis spectrum employ an alternate brain network to engage in complex decision-making

Brain reward processing mechanisms that underlie complex decision-making are compromised in psychosis. The goal of this research was to advance our understanding of the underlying (1) neural mechanisms and (2) discrete neuro-economic/motivational processes that may be altered in complex decision-making in euthymic patients on the psychosis spectrum (PPS). Utilizing a functional magnetic resonance neuroimaging (fmri) paradigm of a well-validated laboratory measure of complex decision-making (Iowa Gambling Task-IGT), the brain activation patterns of a target group of PPS were compared to a demographically matched healthy comparison group (HMC). These two groups were also evaluated on real-life decision outcomes on day of scan. PPS primarily activate the Dorsal Attentional Network (DAN) in real-life decision outcomes and in achieving similar levels of performance on the IGT as the HMC, in-spite of dysregulated dopamine-based brain-reward circuit and salience network fmri activation patterns. However, PPS report more significant negative outcomes of their decision-making in real-life, compared to HMC. The differential engagement of brain networks by PPS on the IGT appear to be moderated by antipsychotic, dopamine antagonist, medication lifetime/daily dose levels. These findings may also be mediated by extent of dysregulation in brain reward circuitry and salience network associated with psychosis severity in the target PPS group. This is also evident in case studies of unmedicated PPS. We conclude by suggesting that the brain may adapt to this dysregulation by co-opting the DAN network, which is implicated in the related function of problem-solving, towards complex decision-making. The extent of utilization of the DAN network in complex decision-making may be moderated by psychosis severity.