Miracle-dz/UniFAR-FTUs huggingface dataset:
Transfer for Sustainable Development at Higher Education Institutions—Untapped Potential for Education for Sustainable Development and for Societal Transformation

Higher education institutions (HEIs) are increasingly confronted with societal needs beyond research and teaching. These include sustainable development and technology transfer as well as the practical application of knowledge and ideas. Several HEIs already put sustainable development and transfer into practice. These practitioner–university partnerships comprise a broad range of actors, disciplines, topics, and formats. However, transfer activities that contribute to sustainable development in society still make up only a very small part of HEIs’ activities. In response to calls from society as a whole, HEIs could combine transfer and sustainable development more systematically. In this article, we suggest a concept of transfer for sustainable development. The focus is on sustainability transfer in teaching. We used mixed methods for this conceptual work: exploratory workshops, expert interviews, and a case study of transfer in teaching. One of the results presented in this article is a working definition of sustainability transfer at HEIs. In addition, six characteristics for describing sustainability transfer in its various forms are formulated. This conceptualization makes it possible to analyze the diversity of HEIs’ sustainability transfer activities, it helps to identify and encourage potential transfer actors at HEIs as well as practitioners, and, thus, tap the full potential of sustainability transfer.
Locally Advanced Gastric Cancer: Current and Future Strategies to Improve Outcomes with Multimodality Approach

Gastric cancer is the sixth most common cancer and the fourth most common cause of cancerrelated death in Europe, causing 107.000 deaths every year. Locally advanced gastric cancer (LAGC) can be defined as clinical T2 disease and beyond with or without confirmed nodal involvement. Surgery is the cornerstone of therapeutic strategies with curative intent, but a significant amount of patients relapse after surgery and 5-year survival rates remain poor (1). Active research on multimodality approach, adding chemotherapy and/or radiotherapy to optimal surgery allowed improvement of survival in the past two decades.
Cascaded Multilevel PV Inverter With Improved Harmonic Performance During Power Imbalance Between Power Cells

The difference in power cell irradiances in cascaded multilevel converters results in different duty cycles among those cells when maintaining the maximum power point tracking (MPPT). However, the difference in cell duty cycles is undesired since it is proportional to the output voltage and current distortions. To this regard, a multilevel topology for photovoltaic (PV) applications is proposed, where an H6 bridge power cell is used instead of an H-bridge one. In case of solar irradiance mismatch among the power cells, the proposed converter injects power with lower voltage from the shaded cells without altering the PV voltage; hence maintaining the MPPT operation. This modification allows us to retain an equal duty cycle in all the power cells whatever the meteorological conditions are present; consequently, maintaining good output voltage and current waveform qualities. To test the effectiveness of the proposed solution, a detailed simulation model as well as an experimental prototype is built. The obtained results show that the proposed topology provides significantly improved output voltage and current qualities compared to the cascaded H-bridge one. The performance of the proposed topology compared to one offering improved harmonics performance, according to the European efficiency, has been also compared, where an enhancement of 2.64% has been registered.
Optimal Sensor Placement for 2-D Range-Only Target Localization in Constrained Sensor Geometry

Localization of an emitting or reflecting target is one of the most important issues in a wide range of applications including radar, sonar, wireless communication and sensor networks. Due to significant effect on the positioning accuracy, designing the optimal sensor-target geometry has been considered as an important problem in the localization literature. The existing sensor placement methods mainly solve the problem in the cases without any constraints on the sensors locations. In the realistic scenarios, however, the sensors cannot be placed simply in arbitrary locations due to such constraints as the geographical limitations, communication problems between the sensor pairs and the security issues. In this paper, the optimal sensor-target geometries under sensor location constraints for range-based positioning are determined based on the A-optimality, E-optimality and D-optimality criteria. First, the special case of two-sensor in a circular area is considered as the permissible sensors placement region, and then, the results are extended to more number of sensors in a connected arbitrarily-shaped sensor region. The proposed sensor placement method can be applied to any application that the target is located outside the sensor region.
The Role of the Circadian System in Reproductive, Neural, and Immune Health

In mammals, the suprachiasmatic nucleus (SCN) acts as the master circadian pacemaker of the body. The SCN coordinate the thousands of individual oscillators throughout the body to maintain optimal health and homeostatic functioning. The importance of maintaining circadian rhythmicity is exemplified by its role in reproduction, as disruption of the circadian clock inhibits reproduction. Experiment 1 shows that the proper temporal coordination by the SCN of two hypothalamic neuropeptides, GnRH and RFRP-3, is imperative to initiation of the luteinizing hormone (LH) surge that stimulates ovulation in the Syrian hamster. The maintenance of temporal homeostasis in reproductive, neural, and immune health was further studied using a model of circadian disruption similar to chronic jet lag that resulted in an incongruence between the endogenous ~24-hour rhythm generated by the SCN and the environmental 24-hour day. In Experiment 2, jet-lagged hamsters exposed to 6-hour shifts in the light:dark cycle every 3 days for 25 days exhibit a dysregulation in the temporal activation of the GnRH and kisspeptin systems, two neuropeptide populations that stimulate the LH surge, and in the temporal deactivation of the RFRP-3 system that inhibits the reproductive axis, around the time of the LH surge. The importance of temporal homeostasis was further explored in Experiment 3, in which jet-lagged hamsters exhibit decreases in hippocampal cell proliferation and neurogenesis compared to non-jet-lagged controls. Interestingly, jet lag hamsters not only exhibit deficits in learning and memory during the period of repeated phase shifts, but also one month following the cessation of chronic jet lag, suggesting that the jet-lag-induced decrease in neurogenesis has long lasting effects on hippocampal function. Similarly, as jet lag influences hippocampal cell proliferation, it is also shown to impact immune function by dysregulating splenocyte proliferation in Experiment 4. Additionally, both innate and humoral immune functions, including complement system activity, total antibody production, and bacterial killing, are suppressed in jet-lagged hamsters compared to controls. Taken together, the previous studies strongly implicate the necessity of coordination between an intact circadian system and environmental cues to maintain proper homeostatic function.
Intergenerational Relationships and Aging Anxiety among Emerging Adults in Turkey

ABSTRACT Recent trends in Turkey indicate that in the near future a considerable percentage of the population will be over the age of 65. One consequence of this demographic development is that grandparents and grandchildren may potentially have more contact with each other as they both age across the life course. As intergenerational contact will become more frequent and extend for a longer period of time, it is important to investigate the influence that grandparents have on their grandchild. This study investigates the relationship between intergenerational contact, emotional closeness and grandparents’ influence on grandchildren’s aging anxiety. Results indicated that perceptions of emotional closeness was influenced by various components of grandparent-grandchild interaction, including physical proximity, contact medium, and contact quality. Grandchild aging anxiety was related to both contact quality, contact frequency, and emotional closeness, but only for the domains of psychological concerns and fear of old people. Results are discussed in the context of both intergenerational influence and Turkish culture.
Modulation of DNA strand break induction and repair bytyrosine kinase inhibitors targeted against EGFR and HER2

Purpose: The human epidermal growth factor receptors EGFR (erbB1) and HER2 (erbB2/neu) are involved in mediating resistance to chemotherapy and ionising radiation (IR). In vitro studies demonstrate that small molecule tyrosine kinase inhibitors (TKIs) which target these receptors can increase the effectiveness of DNA damaging agents. However, these combinations have failed to produce the clinical results anticipated and one potential explanation is that the inhibition of EGFR and HER2 cell signalling pathways by TKIs is short lived, with cells able to switch to alternative mechanisms of signalling through HER3. The purpose of this study was to examine whether the duration of exposure to TKIs modulates the induction and repair of DNA damage produced by chemotherapy or IR and describes attempts to elucidate the role of HER2 in mediating resistance to chemotherapy. Experimental design: Two HER targeting TKIs, lapatinib and gefitinib were investigated. The effect of lapatinib in combination with cisplatin and doxorubicin on the inhibition of cell proliferation and the role of schedule were examined in drug combination assays. The influence of the duration of exposure to TKIs on the induction and repair of DNA lesions induced by cisplatin, IR, doxorubicin, etoposide and m-AMSA were investigated using the alkaline and neutral Comet assays and measurement of γH2AX and RAD51 foci. DNA expression arrays were used to identify the potential mechanisms through which HER2 produces resistance to cisplatin in cells transfected with HER2. Results: Lapatinib is able to synergistically inhibit cell proliferation in combination with cisplatin or doxorubicin in a schedule dependent manner. Duration of exposure to TKIs has no effect on the induction of DNA lesions by cisplatin or IR, but significantly reduces the production of DNA double strand breaks by doxorubicin, etoposide and m-AMSA in part through the down-regulation of the expression of topoisomerase IIα (Topo IIα), increasing resistance to these drugs. Conclusions: These results indicate the scheduling of small molecule TKIs targeted against EGFR and HER2 is important and continuous exposure to these drugs induces resistance to doxorubicin, etoposide and m-AMSA, through reduced expression of their target, Topo IIα. The importance of schedule should be considered when combining TKIs with chemotherapy in clinical practice.
First record of the tropical holothurian Stichopus naso Semper, 1867 (Echinodermata: Holothuroidea: Synallactida) from the temperate coast of Kyushu mainland, Japan, in relation to ocean warming

: In 2011, a tropical holothurian was found off the temperate coast of Kagoshima, Kyushu, Japan. This holothurian was identiﬁed as Stichopus naso Semper, 1867, which was ﬁrst described in the Philippines, and is known to be distributed within the tropical Indo-West Paciﬁc region. Herein, we examined its morphological characteristics and compared it with pre-described examples and discuss its origin from the perspective of climate change and artiﬁcial transfer. We considered that both perspectives are plausible because sea water temperature has recently risen around Japan, creating the possibility of eggs and larval transfer from southern regions and the consequent establishment of adult S. naso populations. Accidental introduction via ballast water from vessels and other pathways may not be implausible. In any case, ocean warming caused by global climate change is considered as a key factor in the survival and settlement of adult S. naso populations.
Impact of forest land cover on runoff, erosion and sedimentation in the Karai Watershed, Simalungun Regency, North Sumatra Province, Indonesia

Received: 17 December 2020 Revised received: 08 March 2020 Accepted: 13 March 2020 Development activities in the Karai Watershed, in upstream area, are intensive. The activities tend to decrease the land abilities in absorbing water and protecting surface soil for erosion, which finally affect the rise of vegetation damage, soil damage, surface run-off and erosion The method of taking samples and analyzing environmental damage were conducted by purposive sampling. Data from laboratory tests of soil physical, chemical and biological properties were analyzed by statistical tests. Measurement result shows that the wide of Karai Watershed is 462 km, in which covered forest wide is 115.5 km (25%) and the wide of non-forest area (garden, dwelling site, road etc) is 346.5 km (75%). Land Cover for non forest area is the biggest sediment source in Karai Watershed. Based on observation on field and laboratory analysis, it shows that conservation activities in natural forest to garden, road, and dwelling site have caused damages to soil (parameter bulk density and total fungi) and environment with indicators of erosion, sediment materials in Karai River and Karai 7 Project location. Observation result shows that program to reduce erosion and sedimentation could be implemented by integrated management program of Karai Watershed with priorities to develop mixed garden and agroforestry.
Stable isotope analysis reveals variable diets of stoats (Mustela erminea) in the alpine zone of New Zealand

The alpine zone of New Zealand covers c. 30% of public conservation land and is home to a high diversity of endemic species. Predation by introduced stoats (Mustela erminea) is identified as a major threat to alpine fauna. However, a lack of biological information, such as what stoats eat in different settings, hinders efforts to focus control measures in time and space in order to achieve the greatest conservation gains. We used a biochemical tool, stable isotope analysis, to estimate stoat diet across three time-periods in the alpine zone of three national parks. We then assessed possible drivers of dietary variation that could lead to greater per capita consumption of native species by stoats. Our models indicate that mammal prey items formed the largest contribution to the metabolic requirements of stoats in long-term estimates (47–90%), but the mid-term (spring and summer) estimates show a greater reliance on insects. The estimated proportions of prey consumed did not differ with elevation, sex, or age, but were significantly different between sites and seasons. Both stoat and ship rat (Rattus rattus) abundance were significant in explaining the proportion of mammals consumed. Higher stoat trap-catch and an absence of ship rats at one site (Nelson Lakes National Park) coincided with a greater range of prey being regularly consumed by stoats; this was the only site to record substantial proportions of birds (26%) and skinks (33%) in stoat diet. Conservation managers should be aware of the potential for marked differences in per capita rates of consumption of threatened alpine species by stoats, possibly linked to differences in abundance of mammalian prey. While this study confirms that stable isotope analysis can be useful to assess the diet of stoats, further research is needed to determine specific isotope enrichment values and to confirm the accuracy of these results.
Role of Sulforaphane on Histone Deacetylase Activity in Solid Ehrlich Carcinoma

Histone acylation is one in every of the posttranslational modification that incorporates a role within the regulation of sequence expression. This study was aimed to ameliorate neoplasm cell model Solid Ehrlich malignant neoplastic disease with sulforaphane extracted from cabbage alone and together with immune suppressant drug (MTX) by study the activity of simple protein deacetylase accelerator (HDAC). In this study, sulforaphane was extracted from cabbage leaves and evaluated victimization GC-MS and ultraviolet illumination spectrophotometry. 60 white male rats were divided into six equal groups. Group I: management ordinarily. The remaining mice were subjected to Ehrlich neoplasm cells. Group II: Tumor-bearing group. Group III: immune suppressant drug “MTX” treated group. Group IV, V treated with SFN before and when Paul Ehrlich cells implantation group VI (Methotrexate and sulforaphane-treated group). This result showed that sulforaphane was extracted from cabbage (Brassica oleracea) in concentration of 833 μg/g leave. HDAC was attenuated when treatment with sulforaphane after treatment with methotrexate or sulforaphane alone. The desoxyribonucleic acid injury was attenuated in neoplasm tissue of tumor-bearing mice when treatment with immune suppressant drug and hyperbolic considerably in tumor tissue of tumor-bearing mice treated with sulforaphane before and after carcinogenesis and together with methotrexate treatment after carcinogenesis.
SEADer++: social engineering attack detection in online environments using machine learning

ABSTRACT Social engineering attacks are one of the most well-known and easiest to apply attacks in the cybersecurity domain. Research has shown that the majority of attacks against computer systems was based on the use of social engineering methods. Considering the importance of emerging fields such as machine learning and cybersecurity we have developed a method that detects social engineering attacks that is based on natural language processing and artificial neural networks. This method can be applied in offline texts or online environments and flag a conversation as a social engineering attack or not. Initially, the conversation text is parsed and checked for grammatical errors using natural language processing techniques and then an artificial neural network is used to classify possible attacks. The proposed method has been evaluated using a real dataset and a semi-synthetic dataset with very high accuracy results. Furthermore, alternative classification methods have been used for comparisons in both datasets.
Effect of gamma rays and EMS on two varieties of soybean

A study was undertaken on induced mutagenesis with CO1 and CO2 varieties of soybean. The mutagens studied were gamma rays (20, 30, 40, 50 and 60 kR) and EMS (5, 10, 15, 20 and 25 mM). In an assessment to fix the LD50 value, the varieties responded differently. A subtle difference was observed between the varieties CO1 and CO2 in the degree of tolerance to the mutagens, viz., CO1, (62 kR gamma rays, 26.4 mM EMS) and CO2 (58.3 kR gamma rays and 25.7 mM EMS). It is concluded that CO1 tolerate higher doses of gamma rays and EMS. In general, the treated population had manifested a reduced expression than the untreated population in all the biometrical traits. Reduction in phenotypic expression is linear with the dose or concentration of the mutagens in M1 generation. The mutagen gamma ray manifested higher percentage of reduction than EMS. In M2, EMS induced higher proportion of chlorophyll mutants than gamma rays. Among viable mutants, sterile mutant occurred more predominantly followed by stunted growth in both the varieties due to the effect of mutation. Induced mutations delivered fairly good amount of genotypic coefficient of variation, the heritability, GA as percent of mean with respect to number of seeds per plant, seed yield per plant and hundred seed weight for both the mutagen in both the varieties, indicating the scope for improving the soybean yield by selection. The mutants with four seeded pods, bold seeded types and increased number of pods per plant were isolated from this experiment
Virological and immunological studies of human cytomegalovirus infection in allogeneic stem cell transplant recipients

Human cytomegalovirus (HCMV) is the most common viral infection complicating stem cell transplantation, and if untreated frequently results in a fatal outcome. In order to identify the main risk factors for HCMV infection, a retrospective study of all allogeneic stem cell transplants performed over a five year period at a single centre was undertaken. The main risk factors for HCMV infection following transplantation were identified as a HCMV seropositive donor and/or recipient and in-vivo use of the monoclonal antibody, anti-CD52 (alemtuzumab). A prospective study of HCMV viral loads determined by real time PCR using a Taqman probe was undertaken, and the viral load dynamics of 57 patients were analysed. Despite the use of aciclovir prophylaxis, PCR monitoring and pre-emptive therapy, the peak viral load, viral replication rate and the total duration of viraemia remain significant risk factors for symptomatic HCMV infection. Peak viral load was the most significant predictor of time to viral clearance. A prospective longtitudinal study of the reconstitution of the HCMV specific immune response following allogeneic stem cell transplantation was performed in 20 patients using intracellular interferon gamma staining and flow cytometry. HCMV infection was associated with a significantly reduced HCMV specific CD4+ T cell response. Furthermore, in patients receiving in-vivo anti-CD52, HCMV specific CD4+ T cell immune recovery was significantly delayed. An HLA class II epitope mapping study was undertaken in stem cell transplant recipients and healthy controls using peptide pools consisting of 15 mer overlapping peptides spanning the entire amino acid sequence of the HCMV proteins, pp65 and IE1. Using intracellular cytokine detection in CD4+ T cells, a number of novel HCMV specific class II epitopes were identified. Transplant recipients responded to a broader range of epitopes than HCMV seropositive controls. These results have important implications for HCMV specific immunotherapy in allogeneic stem cell transplantation.
Vitamin D Regulation of a SOD1-to-SOD2 Antioxidative Switch to Prevent Bone Cancer

Superoxide, a form of reactive oxygen species (ROS), is catabolized by superoxide dismutase (SOD) and contributes to carcinogenesis via the oxidative damage it inflicts on cells. The aim of this research was to analyze the potential vitamin D-mediated regulation of the antioxidative “SOD1-to-SOD2 switch” within the human MG-63 osteosarcoma model. For this study, real-time PCR analysis was performed using MG-63 cells exposed to metabolically active 1,25(OH)2D3. First, a sustained statistically significant >2-fold suppression of proliferating cell nuclear antigen (PCNA) transcripts was observed after 10 nM but not at 100 nM of 1,25(OH)2D3 treatment, suggesting a cytostatic effect. In order to assess regulators of mitochondrial oxidative phosphorylation, gene expression of COX2 and COX4l1 of the mitochondrial complex IV and antioxidative enzymes (SOD1, SOD2 and Catalase (CAT)) were monitored. For COX2 and COX4l1, no changes in gene expression were observed. However, a concomitant decrease in CAT and SOD1 mRNA, and increase in SOD2 mRNA after 24 h of 10 nM 1,25(OH)2D3 treatment were observed. A ~8-fold increase in SOD2 mRNA was apparent after 48 ours. The significant increase in SOD2 activity in the presence of vitamin D indicates an antioxidant potential and sensitization of vitamin D during osteosarcoma transformation and mitochondrial detoxification over time.