Miracle-dz/UniFAR-FTUs huggingface dataset:
Afferent and Efferent Specificity in the Induction and Elicitation of Parental Cross-Protective Immunity by an Immunogenic Murine Tumor Variant: Associative Recognition of a Unique Tumor-specific Antigen on Somatic Cell Hybrids1

Highly immunogenic (Inun* ) murine tumor cell variants can engender a strong tumor-specific, cross-protective immune response against chal lenge with the weakly immunogenic parental tumor cell line. We exam ined the afferent induction and efferent specificity of the parental cross-protective immunity observed following immunization with the limn* variant of the murine fibrosarcoma MCA-F, designated MCA-FM1. Specificity of the afferent and efferent responses against the parental tumor in mice immunized with the MCA-FM1 variant were monitored by challenge with the tumor MCA-D, which expresses a tumor-specific antigen that is immunologically distinct from but biochemically related to the MCA-F antigen. We observed that mixture of MCA-D and MCA-FM1 cells at immunization failed to elicit a strong tumor rejection response against challenge with MCA-D. Challenge of MCA-FM1-iinmune mice with a mixture of MCA-FM1 and MCA-D cells resulted in a significant bystander effect at the site of Inun* rejection, with reduced growth of the MCA-D tumor. To test the hypothesis that the induction of parental cross-protective immunity required the associative recognition of both the Imni*neoantigen and the parental tumor antigen on the same cell, we constructed somatic cell hybrids of MCA-D with either MCA-F or MCA-FM1. Surprisingly, the hybrids did not express either parental tumor-specific antigen present on the fusion partners but displayed a unique antigenic specificity designated F/D. Expression of the F/D anti gen by both the immunogenic and nonimmunogenic hybrid cell lines demonstrated that the tumor-specific F/D antigen was the focus of the cross-protective immunity. These results demonstrate that associative recognition of the tumor-specific parental antigen with the strongly immunogenic neoantigen coexpressed on the surface of the Inun' variant is responsible for the afferent induction and efferent elicitation of anti-parental cross-protective immunity. Furthermore, this study is the first to report that the fusion of two syngeneic tumor cell lines reproducibly results in a new tumor antigen specificity at the expense of the original parental specificities.
Improved ACP mixture design: development and verification

This report describes the testing methodologies and evaluation procedures and criteria for the evaluation of uniaxial compressive creep data to determine the susceptibility of asphalt concrete mixtures to permanently deform or rut. The methodology described and the supporting figures and tables allows the user to perform uniaxial creep testing in accordance with the procedure explained in the Asphalt Aggregate Mixture Analysis System {AAMAS) under a stress state that realistically duplicates the in situ condition for the specific pavement and traffic condition to which the asphalt mixture will be subjected. Furthermore, the procedure provides creep strain, creep curve slope and creep stiffness criteria by which to evaluate the potential of the mixture to deform in specific conditions of pavement structure and traffic. The procedure was developed with the intent of integration into the AAMAS procedure. The reports explains the use of a method to analyze triaxial shear test data in order to determine the susceptibility of asphalt concrete mixtures to deform under specific conditions of loading and in specific pavement structural situations. This procedure is based on the evaluation of the ratio of induced octahedral shear stress to the octahedral shear strength of the asphalt concrete under the specific conditions of stress actually induced in the pavement structure.
Role of the Sympathetic in the Nocturnal Fall in Nervous System Blood Pressure

pressure ("dippers") and those showing no such fall in blood pressure ("nondippers"), we performed 24-hour (h) ambulatory blood pressure monitoring in 25 patients with untreated essential hypertension who were 37-49 years of age (16 men and 9 women). The diagnosis of essential hypertension was based on the patients' history, physical examination, routine laboratory tests, and intravenous pyelography. Blood pressure was measured by sphygmomanometer and by noninvasive ambulatory monitoring for 24 h. Exercise was performed on a supine bicycle ergometer. The initial workload was 50 W and was increased progressively by 25 W at 3-min intervals. Plasma and urinary norepinephrine levels were measured by high-performance liquid chromatography. Dippers were defined as patients with a difference of > 10 mmHg in the systolic BP or > 5 mmHg in the diastolic BP between daytime and nighttime. Eleven patients were dippers and 14 patients were nondippers. There was a positive correlation between the nocturnal fall in blood pressure and the rise in blood pressure during exercise (r= 0.54, p < 0.01), and the increase during exercise was greater in dippers than in nondippers. There was also a significant
SE M ICONDUCTOR ELECTR O CHEMISTRY OF COAL PYRITE

The kinetics of the formation of Fe(HS)2-nn, the intermediate in the formation of FeS (from the reaction between aqueous sulfide ions and dissolved Fe(II) salts) was studied with a stopped-flow spectrophotometric teclmique. As described in the previous report, the absorbance-time curve indicated that a black substance fo_ x ned within the first few seconds of the reaction; this material subsequently decomposed gradually to give a lighter dark product within the following several minutes. It was proposed that an intermediate species, Fe(HS)2"nn, was formed initially from the reaction between Fe2+ and HS- ions in aqueous solution and this intermediate was converted to FeS finally. The kinetic experiments showed that the rate of fomlation of Fe(HS)2-nn was first order with respect to both Fe2+ and HS-, with a rate constant of 103.81 (mol / l)-lsec-1. These results suggest that the black intermediate is FellS +.
Efeito hipotensivo do treinamento de força utilizando diferentes intervalos entre as séries Hypotensive effect in resistance training using different rest intervals between sets

Introduction: The rest interval between sets and exercises is usually related with pressure responses after resistance training (RT). Objective: To compare the changes in systolic blood pressure (SBP) and diastolic (DBP) with different intervals. Methods: Ten subjects were divided by the crossover design into two protocols: T1 – bench press, leg press, lat pull down, leg curl and biceps curl (three sets of ten repetitions at 90% 10RM) with one min interval, T2 – similar protocol, but was adopted three minutes intervals. Results: For SBP, a significant reduction was observed after ten minutes during T1, and between 15 and 20 minutes during T2. For DBP, there was a reduction in T1 between 5 and 40 minutes. For T2, a significant reduction was observed between 15 and 20 minutes. Conclusion: The findings indicate that rest intervals between one and three minutes promoted acute hypotensive effect after a session of RT.
Sex-related differences in cooperation and communication with young infants

We compared ‘emotional coordination’ and ‘non-matching’ in spontaneous dyadic interactions of infant girls and boys with their mothers in early infancy. Eleven infant-mother dyads from Crete, Greece, six with girls, and five with boys, were observed during natural interactions at home from the second to the sixth month of life. Micro-analysis was used to investigate ‘coordination’ and ‘nonmatching’ of facial expressions of emotion. ‘Emotional coordination’ was evaluated with four measures: matching of facial expressions, completion when one responded to the other with ‘pleasure’ or ‘interest’, synchrony by matching frequency of change or rhythm of emotional expressions, and attunement when shifts of emotional intensity of the two partners were in the same direction. ‘Emotional non-matching’was coded when neither the infant nor the mother showed interest in interacting with the other. In emotional coordination or non-matching between mother and infant, who performed first was also recorded. We obtained evidence of sex differences which are summarized as follows. a) ‘Emotional coordination’ was stronger and more accurate with girls, while ‘emotional nonmatching’ was stronger and more frequent with boys. The combination of ‘emotional matching/completion’ was more likely to occur with girls, while the combinations of ‘emotional matching/non-matching’ along with intermittent emotional non-matching were more likely to occur in interactions of infant boys with their mothers. b) Infant girls responded with both ‘emotional matching’ and ‘non-matching’ of their mothers’ emotional expressions more frequently than boys. c) ‘Emotional consistency’ was stronger for pleasure, interest and neutral expressions of girls, while boys ‘emotional consistency’ was stronger for external interest and negative emotion compared to girls’. Mothers of boys showed more intense ‘emotional consistency’ than mothers of girls. d) The developmental trajectories of ‘emotional matching’ and ‘non-matching’ follow different patterns in interactions of girls and boys with their mothers across the age range of this study. In accord with the theory of innate intersubjectivity as an adaptation of human behaviours for social collaborations in action and experience, we assumed that girls and boys may differ in the way they 4 Αssociate Professor of Developmental Psychology, Department of Psychology, University of Crete. E-mail: kokkinaki@uoc.gr
Field-based experimental evolution of three cereal pathogens using a mark – release – recapture strategy

Field-based experimental evolution is a research approach in which study species are allowed to evolve across several generations under well-deﬁned ﬁeld conditions. Field-based experiments in pathogen evolution became feasible with advances in molecular markers and computing technologies. Critical to success of these experiments is the choice of parental genotypes, molecular markers, experimental sites and ﬁeld plot design. The current study used ﬁeld-based experimental evolution based on a mark – release – recapture strategy to analyse the dynamics of interstrain competition and host specialization in the cereal pathogens Zymoseptoria tritici, Phaeosphaeria nodorum and Rhynchosporium commune . In all three pathogen – plant interactions, compelling evidence was found indicating that increasing host heterogeneity by growing cultivar mixtures slowed down the evolution of the corresponding pathogen populations. Evidence for differential selection between parasitic and saprophytic phases of the life cycle in P. nodorum and R. commune was also found. The effect of partial resistance on the evolution of the experimental pathogen populations was mixed. A decreased rate of evolution was found in the pathogen populations sampled from partially resistant hosts in Z. tritici and P. nodorum but not R. commune . The ﬁndings indicate that ﬁeld-based experimental evolution offers a powerful approach to test hypotheses associated with the evolution of plant pathogens.
Some reproductive, fattening and milk yield traits of South Karaman sheep

tarihi/Accepted:13.06. 2020 Aims : In this study, reproductive, lamb growing, fattening and milk yield characteristics of South Karaman ewes and lambs were investigated. Methods and Results : The animal material of the study consisted of South Karaman sheep raised in the nomadic system in Tarsus district of Mersin province. The flock was managed under breeders’ condition. In addition to the pasture, straw and concentrate feed were given to the animals during their stay in Tarsus. The feeding of animals was provided only by grazing in the pasture during the highland period. Lambing rate, number of lambs per ewe at mating period, number of lambs per ewe giving birth, survival rate and single and twin birth rates were calculated to determinate the reproductive characteristics. Fattening characteristics were determined by applying 60 days of fattening in 20 head male animals randomly selected from lambs of similar weight and three months old. Milk yield controls were made at 30 days interval. The Holland method was used for each lactation milk yield calculation. At the end of the study number of lambs per ewe at mating period, birth weight, weaning weight, daily weight gain and lactation milk yield were detected as 1.24, 3.4±0.07 kg, 16.7±0.18 kg, 232.8±10.24 g and 37.7 L, respectively. Conclusions : South Karaman sheep has low milk yield, fattening and reproductive characteristics similar to other fat-tailed native breeds under semi-intensive breeding conditions. Significance and Impact of the Study : At the end of the study, it can be stated that South Karaman sheep is an important breed to sustainable sheep production systems. The reproductive, fattening and milk yield characteristics of this breed are sufficient for sheep farmers, especially nomadic
Geochemical investigations from the Kimberley area, of kimberlites South Africa

Fifteen major components and 21 trace elements (Li, F, S, Cl, V, Cr, Co, Ni, Cu, Zn, Rb, Sr, Y, Zr, Nb, Cd, Ba, Hg, TI, Pb and Bi) were analyzed for 11 kimberlites and 3 xenoliths (garnet peridotite, eclogite and gabbro) from South Africa. Selected major and trace element contents of olivine, serpentine, pyrox ene, phlogopite, perovskite, spinel, magnetite, Fe-Ni-Cu-S ores and native copper in several kimberlites were also measured. Sulfur isotope compositions of 5 kimberlites and a garnet peridotite range from 634S -3 to +9.6%o. The concentrations of major elements and Cr, Co, Ni, Zn, Hg have a small, but those of Li, Na, K, Rb, Cl and TI a wide range of variation. Good correlations of K-Rb have to be mentioned. Large Fe203/FeO ratios indicate relatively high oxygen fugacities during eruption. Additional data on about 60 elements in bulk kimberlites have been compiled from the literature to estimate the average chemical com position of kimberlites. In order to know the accumulation and depletion of elements during magma for mation, the elemental abundances of kimberlites were compared with those of undepleted mantle rocks. Kimberlites are characterized by very high concentrations of incompatible and volatile elements such as La, Ce, C, Nd, Th, U, F, Cs, Nb, Sm, Ta, Rb, Ba, K, P, Pb and Sr, and low concentrations of Si, Na, Al and heavy REE. Concentrations of the former elements suggest that kimberlite magmas are produced by a small degree of partial melting in the presence of CO2 and H20 under upper mantle conditions.
Selected Trace Element Concentrations in Peat Used for Cosmetic Production – A Case Study from Southern Poland

Abstract The aim of the study was to assess the concentration of selected trace elements in organic soils used as a source to obtain a unique peat extract for cosmetics production. Peat material for laboratory analysis were collected from fen peatland located in the Prosna River Valley (Borek village). Studied peatland is managed by “Torf Corporation” company as a source of material to obtain peat extract for cosmetics production. In the collected soil samples (four soil profiles) Zn, Cu and Pb concentrations were determined by using atomic absorption spectrometer SpectraAA 220 (Varian), after acid digestion. Obtained results showed that the highest concentrations of selected trace elements were recorded in the surface horizons of organic soils. This fact might be the results of Prosna river flooding or air deposition. Howevere, according to the new Polish regulations (Ordinance of the Minister for Environment 01.09.2016 - the way of conducting contamination assessment of the earth surface), the content of trace elements in the examined soils was greatly belowe the permissible limit for areas from group IV (mine lands). Thus, described soils are proper to obtain peat extract used as a component in cosmetic production.
The Impact of Family Friendly Workplaces on Satisfaction and Work

This paper provides novel evidence on the effect of family-friendly firm policies on satisfaction and working time of parents. The focus of this study is on two specific firm policies: Childcare support and flexible working schedules. We exploit the fact that since the mid 2000s an increasing share of employers react to their employees' needs by offering a family-friendly work environment. These changes over time allow us to identify causal effects of the two family-friendly policies. Identification is based on a difference-in-differences strategy in a panel dataset on families with young children in Germany (FiD). The model is combined with matching to decrease potential bias arising from observable factors correlated with the offer of family-friendly policies and the change in the considered outcomes. We find that for mothers, childcare support strongly increases satisfaction related to childcare and additionally raises life and job satisfaction. Particularly middle and lower educated mothers increase their working time when childcare support is offered. The effects are mainly driven by immediate use of childcare support. Flexible working schedules only affect mothers' job satisfaction, but do not seem to change family related satisfaction and working time. Fathers show nearly no reactions to either childcare support or flexible working schedules. Childcare support seems to be a truly family-friendly practice and valued by mothers, while this is not so clear for flexible working schedules.
Supercritical heterogeneous nanostructure of fluids. Part 1. Diagram of fluctuation transitions in non-gibbsian phases

New concept of a supercritical fluid (SCF) region is proposed to recognize the set of the recent experimental observations and the numerical model results, in which the conventional asymptotic scaling theory and its crossover extension achieve the limit of applicability. An existence of the heterogeneous steady lattice-type nanostructure in the wide ranges of supercritical parameters termed the non-gibbsian fluid (NGF)-phase was hypothesized by one of authors (V.B.R.) in the framework of FT (fluctuational thermodynamics)-model. It was argued by FT-model that the similar NGF-phase exists also below the critical temperature in any real finite-volume VLE-transition. The present work establishes the location of exact boundaries for the supercritical lattice-type NGF-phase confirmed by the set of recently published experimental results and simulations. In brief, the total supercritical region consists of the dilute gas-like (gl) gibbsian (homogeneous) phase (GPh) and the dense liquid-like (ll) gibbsian (homogeneous) phase (GPh) separated one from another by the heterogeneous (at least, in nanoscales of a finite volume) vapor-like (vl) NGF-phase. The practical usage of a such structure may be quite promising in many areas of applications. It is certainly non-restricted by only the known advances of a supercritical extraction processing.
Control Parameters for Understanding and Preventing Process Imbalances in Biogas Plants. Emphas on VFA Dynamics

Two thermophilic continuously stirred tank reactors (CSTR), R1 and R2, were subject to pulses of tryptone and ammonia. R1 was operated at an ammonia concentration of 3.0 g-N/l, corresponding to the average ammonia concentration in Danish centralized biogas plants. R2 was operated at an ammonia concentration of 1.7 g-N/l. Shock loads of tryptone (10 g/l, 10 g/l, 15 g/l) had an immediate stimulating effect on methanogenesis for both reactors illustrated by significant peaks in methane production but also lead to a hydraulic overloading illustrated by a steep increase in volatile fatty acids (VFA) concentration. Three days after the pulses a second peak in acetate concentration and a decrease in methane production indicated an ammonia-inhibition of the acetoclastic methanogens. During the pulses of tryptone the performance of R1 was slightly more affected than R2. Pulses of ammonia (0.79 g-N/l) resulted in a decrease in methane production of both reactors but no immediate increases in VFA concentrations was observed illustrating that the ammonia inhibition during this experiment was an overall inhibition of the biogas process and not only an inhibition of the methanogens.
Factors affecting blood pressure in patients with hypertension and subclinical hypothyroidism

Background: The aim our study was to identify factors affecting blood pressure in patients with hypertension (HTN) and subclinical hypothyroidism (SH). Material and methods: One hundred and thirty-eight patients aged from 25 to 59 years were examined and divided into control group (n = 30), euthyroid patients with HTN (n = 45) and patients with HTN in combination with SH (n = 63). The levels of tumor necrosis factor- a , C-reactive protein, total hydroperoxide content, total antioxidant activity, total superoxide dismutase activity and sirtuin 1 were measured in addition to complete blood count and routine biochemical tests. The Kruskal-Wallis H test was used to test whether there was a significant difference between the independent and its dependent variables. Results: Fewer factors affected systolic and diastolic blood pressure in patients with HTN and SH compared with euthyroid patients. These included age, waist circumference, insulin, triglycerides, very high-density lipoprotein cholesterol, and TAA. The opposite results were found in relation to the increase in pulse pressure: significant effects of gender, hemoglobin, alkaline phosphatase were observed in patients with SH and only the level of ACT had a significant influence in euthyroid patients. Conclusions: Factors associated with blood pressure and their overall number differed among patients with SH and HTN compared with euthyroid patients with HTN. Such results may be due to changes in anthropometric parameters, metabolic profile and oxidative status in patients with concomitant SH.
Dehydration, stroke and dysphagia: systematic review Desidratação, acidente vascular cerebral e disfagia: revisão sistemática da literatura

de Lima Friche 3  ABSTRACT Purpose: this is a systematic review of scientific literature associated with stroke, dehydration and oropharyngeal dysphagia (OD). Research strategy: bibliographic survey was conducted in scientific databases: MEDLINE, LILACS, SciELO, Web of Science and Cochrane. Selection criteria: studies that met the following inclusion criteria were included: being original article with summary available; have been published in the last seventeen years (2001-2018) and in Portuguese, English or Spanish languages; and addressing dehydration in individuals after stroke Screening and analysis of the studies were performed by two independent evaluators. Results: among the 484 articles found for screening, 43 were selected for full reading and 18 articles were included in the final analysis. Different methods of assessing hydration status have been described in individuals post-stroke, such as ratio analysis blood urea nitrogen (BUN)/creatinine, plasma osmolality, urea / creatinine, urine specific gravity, urine color, water intake, water balance, bioelectrical impedance analysis (BIA), clinical evaluation and analysis of electrolytes. The prevalence of dehydration in post-stroke during hospitalization varied from 11% to 66% and is associated with severity and deterioration in the clinical evolution. Conclusion: It was possible to understand the complexity of the measurement of hydration status in individuals after stroke and its association with dysphagia. Studies focusing on the association between dehydration and stroke are very important, due to its influence on mortality