Miracle-dz/UniFAR-FTUs huggingface dataset:
Ubiquitination of Receptorsomes, Frontline of Plant Immunity

Sessile plants are constantly exposed to myriads of unfavorable invading organisms with different lifestyles. To survive, plants have evolved plasma membrane-resident pattern recognition receptors (PRRs) and intracellular nucleotide-binding domain leucine-rich repeat receptors (NLRs) to initiate sophisticated downstream immune responses. Ubiquitination serves as one of the most important and prevalent posttranslational modifications (PTMs) to fine-tune plant immune responses. Over the last decade, remarkable progress has been made in delineating the critical roles of ubiquitination in plant immunity. In this review, we highlight recent advances in the understanding of ubiquitination in the modulation of plant immunity, with a particular focus on ubiquitination in the regulation of receptorsomes, and discuss how ubiquitination and other PTMs act in concert to ensure rapid, proper, and robust immune responses.
Completion of the Total Synthesis of Several Bioactive Sarpagine/Macroline Alkaloids including the Important NF-κB Inhibitor N4-Methyltalpinine

The unification of the general synthetic strategy regarding the important and emerging group of C-19 methyl-substituted sarpagine/macroline alkaloids has culminated in the completion of the total synthesis of several bioactive alkaloids. Key transformations include an ACE-Cl mediated late-stage N(4)-demethylation and an anhydrous acid-mediated intramolecular quaternary hemiaminal formation between a tertiary amine and an aldehyde function to allow efficient access to several biologically important alkaloids from this group. Herein, the enantiospecific total synthesis of the first known sarpagine/macroline alkaloid with NF-κB inhibitory activity, N(4)-methyltalpinine (as a chloride salt), as well as the anticancer alkaloids talpinine, O-acetyltalpinine, and macrocarpines F–G, are described.
Flat Physicalism

This paper describes a version of type identity physicalism, which we call Flat Physicalism , and shows how it meets several objections often raised against identity theories. This identity theory is informed by recent results in the conceptual foundations of physics, and in particular clar-ifies the notion of ‘ physical kinds ’ in light of a conceptual analysis of the paradigmatic case of reducing thermodynamics to statistical mechanics. We show how Flat Physicalism is compatible with the appearance of multiple realisation in the special sciences, and how and in what sense the special sciences laws are autonomous from the laws of physics, despite the full reductive picture of Flat Physicalism. We compare our view with a recent proposal by William Bechtel that accounts for the appearance of levels in mechanistic explanations.
The Well-Being of the German Adult Population Measured with the WHO-5 over Different Phases of the COVID-19 Pandemic: An Analysis within the COVID-19 Snapshot Monitoring Study (COSMO)

The aim of this study is to evaluate factors associated with the subjective well-being (SWB) and suspected depression measured with WHO-5 among German adults during different phases of the COVID-19 pandemic. Survey data were analyzed from the COVID-19 Snapshot Monitoring (COSMO) study, which collected data from 972, 1013, and 973 participants in time point 1 (19–20 May 2020), time point 2 (15–16 September 2020), and time point 3 (21–22 December 2020), respectively. Descriptive analyses and logistic regression analyses to identify the factors associated with suspected depression (WHO-5 ≤ 50) were conducted. Data showed that the mean WHO-5 scores in three time points were 56.17, 57.27, and 53.93, respectively. The risk of suspected depression was increased by about 1.5 times for females, 2.5–3 times among 18–24 year-olds compared to ages above 65 years, 1.5 times for singles, 2 times for those with chronic illnesses, and 2–3 times for people living in poverty. The main study findings show that German adult SWB is lower than pre-pandemic reference values. Special focus should be placed on vulnerable groups, such as females, younger persons, and people living in poverty who are most prone to a reduction in SWB and therefore suspected depression.
Can High Levels of Hindrance Demands Increase the Worker’s Intellectual Response?

Job demands are factors that are associated with a physical and psychological cost when it comes to coping with them, but which can also positively affect the motivational process. Demands such as overload, defined as an excessive workload, have not presented positive results in any of the studies that have related it to employee engagement. The present study aims to delve into the possible positive effect of this demand on the intellectual bonding of employees. It is hypothesized that: (a) Initially, the increase in the perception of work overload will show a negative influence on the intellectual engagement of the employees; but (b) high perceptions of overload will change this effect, producing an increase in the intellectual dimension of engagement. The sample is made up of 706 employees of a Spanish multinational company. The results support this asymmetric curvilinear influence. The level of intellectual engagement is significantly reduced when the role overload increases from the lower values of the scale. However, upon reaching high levels of role overload, the intellectual engagement response begins to grow. These results challenge the conceptualization of overload as only negative and opens the door to consider that the positive response to a demand can also occur at high levels of it.
Boulder Dislodgement During Coastal Storms and Tsunamis: Insights From a New Ensemble Model

Boulders are excellent candidate deposits to study coastal inundation events by storms and tsunamis due to their significant preservation potential. However, it is difficult to infer how and what forcing dislodged the boulder. We present a new model that enables ensemble and Monte‐Carlo‐type simulations to study the sensitivity of boulder, the fluid flow, and environmental parameters. Our examples show that boulder transport is complex and nonlinear, and to acknowledge the uncertainties of the boulder's preexisting transport conditions, a range of velocities and environmental parameters should be used to quantify the flow that caused boulder dislodgement.
Non-Performing Loans of Commercial Banks, and Their Causes: Evidence from Vietnam

Non-Performing Loans (NPLs) are a significant issue for all banks in Vietnam, attracting considerable attention from scholars. Our research aims to nd out the factors that affect the NPLs of Vietnamese commercial banks. The study uses Pooled Ordinary Least Square (OLS), Fixed effect, Random effect, and Generalized Least Square to examine secondary data of 28 commercial banks annually for the period 2008-2019. Consistent with previous research, the main finding shows that macroeconomic and microeconomic factors impact NPLs. Remarkably, provision for credit risk (PCR) has a significantly positive effect on the NPL ratio. Besides, foreign investor ownership (FOR) and bank size (SIZE) negatively affect the NPL ratio. Especially, for the positive correlation between foreign investor ownership and bank performance, the commercial bank should expand to enhance operational efficiency. Regarding macro factors, the results conclude that gross domestic product (GDP) growth and the unemployment rate (UEP) have a significantly negative relationship on NPLs. Therefore, the State Bank of Vietnam and the banks need to understand the leading causes as they directly relate to the banks in the context of the prevailing economic environment.This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium provided the original work is properly cited.
Lenvatinib with or without Concurrent Drug-Eluting Beads Transarterial Chemoembolization in Patients with Unresectable, Advanced Hepatocellular Carcinoma: A Real-World, Multicenter, Retrospective Study

Introduction: Lenvatinib is the first-line treatment for advanced hepatocellular carcinoma (HCC). We aimed to compare the clinical outcomes of lenvatinib plus drug-eluting beads transarterial chemoembolization (DEB-TACE) versus lenvatinib alone in real-world practice. Methods: This retrospective analysis included 142 consecutive patients who received lenvatinib plus DEB-TACE and 69 patients who received lenvatinib alone as first-line treatment from 15 Chinese academic centers from November 2018 to November 2019. Overall survival (OS), progression-free survival (PFS), objective response rate (ORR) were evaluated by modified Response Evaluation Criteria in Solid Tumors criteria, and safety profiles were compared between the two groups. Results: The median OS and PFS were significantly longer in the combined therapy group than in the monotherapy group in whole cohort (median OS, 15.9 vs. 8.6 months, p = 0.0022; median PFS, 8.6 vs. 4.4 months, p < 0.001) and after propensity score matching analysis (median OS, 13.8 vs. 7.8 months, p = 0.03; median PFS, 7.8 vs. 4.5 months, p = 0.009). Moreover, the treatment option was an independent prognostic factor for OS and PFS with adjustment based upon baseline characteristics (adjusted hazard ratio [HR]: 0.53, 95% confidence interval [CI]: 0.36–0.78, p = 0.001, and adjusted HR: 0.42, 95% CI: 0.30–0.60, p < 0.001, respectively) and propensity score (adjusted HR: 0.52, 95% CI: 0.36–0.76, p = 0.001, and adjusted HR: 0.46, 95% CI: 0.33–0.64, p < 0.001, respectively). Moreover, a greater ORR was observed in the combined group (ORR: 46.48% vs. 13.05%, p < 0.001). Furthermore, the most common adverse events (AEs) were elevated aspartate aminotransferase (54.9%) and fatigue (46.4%) in the lenvatinib plus DEB-TACE group and lenvatinib group, respectively. Most AEs were mild-to-moderate and manageable. Conclusions: With well-tolerated safety, lenvatinib plus DEB-TACE was more effective than lenvatinib monotherapy in improving OS, PFS, and ORR. Thus, it may be a promising treatment for advanced HCC. Future prospective studies confirming these findings are warranted.
Information literacy in the legal workplace: Current state of lawyers’ skills in Pakistan

This study investigated the current state of information literacy (IL) skills among lawyers practicing at the District Bar Association of Sargodha, Punjab, Pakistan. A cross-sectional survey using a questionnaire was conducted to collect data from 297 lawyers. The questionnaire comprised 20 statements related to information literacy along with certain demographic variables. Each lawyer was personally visited in the assigned chamber by one of the researchers to record responses. Both descriptive (frequencies, percentages, mean scores, standard deviations) and inferential statistics (Pearson correlation coefficient, t-test, and one-way analysis of variance) were applied for data analysis in SPSS. The results showed that a large majority of lawyers participating in the survey never received any formal training concerning information literacy. However, most of these lawyers perceived IL skills as important in the context of their workplace especially in conducting legal research. These lawyers were more competent in the basic IL skills and less competent in advanced IL skills. In addition, the lawyers’ age, practical experience, practicing levels, computer proficiency, and English Language proficiency predicted their levels of IL skills. There was a critical need for the development of IL instruction programs for not only practicing lawyers but also for law students to improve their skills since these lawyers felt less competent with advanced levels of IL skills. It is hoped that the present study contributes to the existing body of WIL literature focusing especially on the role of IL in the context of legal work and outlining the current state of lawyers’ IL skills in Pakistan as no such study has appeared so far.
Tooth loss, Prosthodontic Treatment need and Association Factors in A sample of Adults attending College of Dentistry,Al Mustansiriya University.

The aim of this study was to evaluate the level of tooth loss, the prosthetic treatment need and associated factors in a sample of the over 20-years old patients attending college of dentistry,AL Mustansiriya University. A sample of 584 individuals (306males and 278 females) was selected from prosthodontics department. The data were collected by means of an oral examination and interviewer questionnaire. The present study showed that the level of tooth loss more in male than female and increasing with age. A number of factors are involved in the decision to extract teeth, which are mainly dental caries and periodontal disease. Prevalence of denture wear is low and high need for prosthetic treatment especially in those with lower levels of education and lower income.Knowledge of factors that influence tooth loss and wearing dentures is important for the effective planning and provision of oral health services, particularly in prioritising prosthodontic care.
From ecosystem to community. Combining entrepreneurship and university engagement in an open innovation perspective

: The paper provides a new perspective for the analysis of academic entrepreneurship dynamics in an evolving open innovation context. Starting from an overview of the innovation (eco) systems approach and a focus on university engagement, we propose a paradigm shift towards the conceptualisation of an innovation community (IC) within and around higher education institutions (HEIs) boundaries. The main goal of the study is to show that the concept of IC can be applied to a knowledge-intensive hub, where open innovation (OI) processes successfully enhance knowledge flows in the context of advanced education programs and spin-off firm creation and management. Our research is explorative in nature and structured around a multiple case study methodology. The outcomes confirm that the IC view can acquire a theoretical relevance when referring to OI contexts involving public, private and institutional sectors. Practical implications include a further framework for both technology transfer operators and institutions.
Ecosystem adaptation to climate change: the sensitivity of hydrological predictions to time-dynamic model parameters

Abstract. Future hydrological behavior in a changing world is typically predicted based on models that are calibrated on past observations, disregarding that hydrological systems and, therefore, model parameters may change as well. In reality, hydrological systems experience almost continuous change over a wide spectrum of temporal and spatial scales. In particular, there is growing evidence that vegetation adapts to changing climatic conditions by adjusting its root zone storage capacity, which is the key parameter of any terrestrial hydrological system. In addition, other species may become dominant, both under natural and anthropogenic influence. In this study, we test the sensitivity of hydrological model predictions to changes in vegetation parameters that reflect ecosystem adaptation to climate and potential land use changes. We propose a top-down approach, which directly uses projected climate data to estimate how vegetation adapts its root zone storage capacity at the catchment scale in response to changes in the magnitude and seasonality of hydro-climatic variables. Additionally, long-term water balance characteristics of different dominant ecosystems are used to predict the hydrological behavior of potential future land use change in a space-for-time exchange. We hypothesize that changes in the predicted hydrological response as a result of 2 K global warming are more pronounced when explicitly considering changes in the subsurface system properties induced by vegetation adaptation to changing environmental conditions. We test our hypothesis in the Meuse basin in four scenarios designed to predict the hydrological response to 2 K global warming in comparison to current-day conditions, using a process-based hydrological model with (a) a stationary system, i.e., no assumed changes in the root zone storage capacity of vegetation and historical land use, (b) an adapted root zone storage capacity in response to a changing climate but with historical land use and (c, d) an adapted root zone storage capacity considering two hypothetical changes in land use. We found that the larger root zone storage capacities (+34 %) in response to a more pronounced climatic seasonality with warmer summers under 2 K global warming result in strong seasonal changes in the hydrological response. More specifically, streamflow and groundwater storage are up to −15 % and −10 % lower in autumn, respectively, due to an up to +14 % higher summer evaporation in the non-stationary scenarios compared to the stationary benchmark scenario. By integrating a time-dynamic representation of changing vegetation properties in hydrological models, we make a potential step towards more reliable hydrological predictions under change.
Perception and challenges of health science students toward e-learning in a Sub-Saharan African country: a multi-institutional study

Background: E-learning is important in improving access to quality health sciences education. This study aimed to determine the perspectives of Kenyan health science students toward e-learning in a bid to enhance effective learning during the COVID-19 pandemic and beyond. Methods: This descriptive cross-sectional study targeted 294 Kenyan health science students. Approval was obtained from the Kenyatta National Hospital–University of Nairobi Ethics Research Committee, and informed consent was obtained from participants. Data were collected using Google Forms and analyzed using SPSS version 27.0. A p value ≤0.05 was considered significant at 95% confidence interval. Results: Most students had good knowledge of online learning; 74.9% reported having received training on the same by their universities and 74.5% further reported to have taken tests on the same. Almost half (45.5%) were knowledgeable of the use of the internet to access materials. Most (79.6%) portrayed a positive attitude toward online learning, agreeing to its use as an integral part of learning. However, 70.2% noted a decrease in concentration and changes in reading habits (44.7%). Regarding challenges faced, unreliable internet connection (56.9%) and lack of motivation (73.7%) were common. Conclusion: The majority of the Kenyan health science students portrayed good knowledge, attitude, and practice toward e-learning amidst challenges.
The Effect of Work Environment and Work Pressure on Job Satisfaction and the Impact on Employees Performance of West Jakarta DJP Regional Office

This study aims to determine the effect of work environment and work pressure on employee performance, the effect of the work environment on employee performance, the effect of job pressure on employee performance, the effect of job satisfaction on employee performance, the influence of the work environment on employee performance through job satisfaction variables, the effect of job pressure on employee performance through job satisfaction variables. The study was conducted on employees of the West Jakarta DJP Regional Office. The sampling technique used the saturated sample method involving 86 people. Data analysis using path analysis. The results of the study indicate that the work environment and work pressure variables affect employee performance. The calculated F value is 32.598 and the significance is 0.05. This value is smaller than 0.05. The r-squared value of 44.0% means that the work environment and work pressure variables affect employee performance by 44.0% while the rest is influenced by other variables that are not included in the equation model. Work environment variables affect employee performance partially. The t value is 7,310. The significance value is 0.00. This significance value is smaller than 0.05. The value of r squared is 38.9%. This means that the effect of work environment variables on employee performance is 38.9% and the rest is influenced by other variables that are not included in the equation model. The work pressure variable partially affects employee performance. The t value is 2.055. The significance value is 0.043. This significance value is smaller than 0.05. The value of r squared is 0.048. This means that the influence of the work pressure variable on employee performance is 4.8% and the rest is influenced by other variables that are not included in the equation model. Job satisfaction variable affects employee performance partially. The t value is 5,610. The significance value is 0.00. This significance value is smaller than 0.05. The value of r squared is 0.273. This means that the influence of the satisfaction variable on employee performance is 27.3% and the rest is influenced by other variables that are not included in the equation model. The effect of the work environment on employee satisfaction is 0.624. The effect of the work environment on employee satisfaction through job satisfaction is 0.385 x 0.522 = 0.201. In this case, the direct effect is greater than the indirect effect, so it can be said that the job satisfaction variable is not an intervening variable. The direct effect of work pressure on employee satisfaction is 0.219. While the effect of work pressure on employee performance through job satisfaction is 0.164 x 0.522 = 0.086. In this case, the direct effect is greater than the indirect effect, so it can be said that the job satisfaction variable is not an intervening variable.
Detection of HIV Virologic Failure and Switch to Second-Line Therapy: A Systematic Review and Meta-analysis of Data From Sub-Saharan Africa

Abstract Background The late recognition of virologic failure (VF) places persons with HIV in Sub-Saharan Africa at risk for HIV transmission, disease progression, and death. We conducted a systematic review and meta-analysis to determine if the recognition and response to VF in the region has improved. Methods We searched for studies reporting CD4 count at confirmed VF or at switch to second-line antiretroviral therapy (ART). Using a random-effects metaregression model, we analyzed temporal trends in CD4 count at VF—or at second-line ART switch—over time. We also explored temporal trends in delay between VF and switch to second-line ART. Results We identified 26 studies enrolling patients with VF and 10 enrolling patients at second-line ART switch. For studies that enrolled patients at VF, pooled mean CD4 cell count at failure was 187 cells/mm3 (95% CI, 111 to 263). There was no significant change in CD4 count at confirmed failure over time (+4 cells/year; 95% CI, –7 to 15). Among studies that enrolled patients at second-line switch, the pooled mean CD4 count was 108 cells/mm3 (95% CI, 63 to 154). CD4 count at switch increased slightly over time (+10 CD4 cells/year; 95% CI, 2 to 19). During the same period, the mean delay between confirmation of VF and switch was 530 days, with no significant decline over time (–14 days/year; 95% CI, –58 to 52). Conclusions VF in Africa remains an event recognized late in HIV infection, a problem compounded by ongoing delays between VF and second-line switch.