Miracle-dz/UniFAR-FTUs huggingface dataset:
Incidence, clinical features and risk factors of tacrolimus induced idiosyncratic liver injury in renal transplant recipients: A nested case-control study

Rare data reported tacrolimus-induced liver injury (tac-DILI) in real world. We performed a nested case-control analysis of 1,010 renal transplant recipients. Recipients with tac-DILI were randomly matched at a ratio of 1:4 by the year of admission to the remaining recipients without tac-DILI to explore risk factors. The incidence of tac-DILI was 8.9% (95% CI = 7.2–10.7%). The most common type was cholestatic pattern (6.7%, 95% CI = 5.2–8.3%), followed by hepatocellular (1.6%, 95% CI = 0.8–2.4%) and mixed patterns (0.6%, 95% CI = 0.1–1.1%). 98.9% of recipients with tac-DILI have mild severity. The latency period were 42.0 (range, 21.5–99.8 days), 14.0 (range, 9.0–80.3 days), 16.0 (range, 11.5–24.5 days), and 49.0 days (range, 28.0–105.6 days) for total, hepatocellular, mixed, and cholestatic patterns, respectively. Baseline ALP level (OR = 1.015, 95% CI = 1.006–1.025, p = 0.002), age (OR = 0.971, 95% CI = 0.949–0.994, p = 0.006), and body weight (OR = 0.960, 95% CI = 0.940–0.982, p < 0.001) were independent risk factors. In conclusion, cholestatic pattern represents the most frequent type of tac-DILI. Young age, low body weight and abnormal baseline ALP level were risk factors.
Biological Consequences of Vanadium Effects on Formation of Reactive Oxygen Species and Lipid Peroxidation

Lipid peroxidation (LPO), a process that affects human health, can be induced by exposure to vanadium salts and compounds. LPO is often exacerbated by oxidation stress, with some forms of vanadium providing protective effects. The LPO reaction involves the oxidation of the alkene bonds, primarily in polyunsaturated fatty acids, in a chain reaction to form radical and reactive oxygen species (ROS). LPO reactions typically affect cellular membranes through direct effects on membrane structure and function as well as impacting other cellular functions due to increases in ROS. Although LPO effects on mitochondrial function have been studied in detail, other cellular components and organelles are affected. Because vanadium salts and complexes can induce ROS formation both directly and indirectly, the study of LPO arising from increased ROS should include investigations of both processes. This is made more challenging by the range of vanadium species that exist under physiological conditions and the diverse effects of these species. Thus, complex vanadium chemistry requires speciation studies of vanadium to evaluate the direct and indirect effects of the various species that are present during vanadium exposure. Undoubtedly, speciation is important in assessing how vanadium exerts effects in biological systems and is likely the underlying cause for some of the beneficial effects reported in cancerous, diabetic, neurodegenerative conditions and other diseased tissues impacted by LPO processes. Speciation of vanadium, together with investigations of ROS and LPO, should be considered in future biological studies evaluating vanadium effects on the formation of ROS and on LPO in cells, tissues, and organisms as discussed in this review.
A Semiconductor Laser as a Stable Phase Conjugate Mirror for Linewidth Reduction of Another Semiconductor Laser

An AlGaAs laser was used as a phase conjugate mirror. Reflectivities as high as 103 and bandwidth as wide as 1.9 GHz were observed. The linewidth of a second AlGaAs laser was reduced to 1/5 times that of its free-running value by optical feedback of the phase conjugate wave generated by the first laser. The reduced linewidth was independent of the separation between the two lasers, and was maintained in a stable manner for over two hours.
Quantiles for Fractions and Other Mixed Data

This paper studies the estimation of quantile regression for fractional data, focusing on the case where there are mass-points at zero or/and one. More generally, we propose a simple strategy for the estimation of the conditional quantiles of data from mixed distributions, which combines standard results on the estimation of censored and Box-Cox quantile regressions. The implementation of the proposed method is illustrated using a well-known dataset.
Premature Pubarche: Time to Revise the Diagnostic Approach?

Premature pubarche (PP) could represent the first manifestation of non-classic congenital adrenal hyperplasia caused by 21 hydroxylase deficiency (NC21OHD) (10–30% of cases). In the last 20 years, the necessity of performing an ACTH test to diagnose NC21OHD in all cases with PP has been questioned, with conflicting results. This study aims to retrospectively evaluate the predictive value of the basal androgens, 17-OHP levels, and auxological features in suggesting the presence of NC21OHD and, thus, the need for a standard ACTH test to confirm the diagnosis. In all, 111 consecutive patients (87 females) with PP and advanced bone age underwent an ACTH test. Of these, 6/111 cases (1 male) were diagnosed with NC21OHD. The mean baseline 17 hydroxyprogesterone (17-OHP), dehydroepiandrosterone (DHEA), dehydroepiandrosterone sulfate (DHEA-S), delta 4 androstenedione (Δ4A), and testosterone serum levels were higher in NC21OHD patients than in the others (p < 0.05). We found three predictive features for NC21OHD: basal 17 OHP of >200 ng/mL, bone age advance of >2 years, and DHEA-S levels of >228 ng/mL with sensitivity and specificity of 83.3% and 97.1%, 83.3% and 65.7%, and 83.3% and 96.2%, respectively. Our data confirm that the prevalence of NC21OHD is low among patients with PP. Serum 17-OHP of >200 ng/mL could be helpful to decide, in most cases, which patients should undergo the ACTH test. Bone age advance represented an inadequately specific predictive marker of NC21OHD.
A Generalized Eigenvalue Approach for Solving Riccati Equations

A numerically stable algorithm is derived to compute orthonormal bases for any deflating subspace of a regular pencil $\lambda B - A$. The method is based on an update of the $QZ$-algorithm, in order to obtain any desired ordering of eigenvalues in the quasitriangular forms constructed by this algorithm. As applications we discuss a new approach to solve Riccati equations arising in linear system theory. The computation of deflating subspaces with specified spectrum is shown to be of crucial importance here.
LTF Induces Radioresistance by Promoting Autophagy and Forms an AMPK/SP2/NEAT1/miR-214-5p Feedback Loop in Lung Squamous Cell Carcinoma

Radiotherapy is the most predominant treatment strategy for lung squamous cell carcinoma (LUSC) patients, but radioresistance is the major obstacle to therapy effectiveness. The mechanisms and regulators of LUSC radioresistance remain unclear. Here, lactotransferrin (LTF) is found to be significantly upregulated in radioresistant LUSC cell lines (H226R and H1703R) and clinical samples and promotes radioresistance of LUSC both in vitro and in vivo. Comprehensive enrichment analyses suggested that LTF potentially modulates autophagy in LUSC. Interestingly, the level of autophagy was raised in the radioresistant cells, and suppression of autophagy sensitized LUSC to irradiation. Functional experiments showed that LTF deficiency inhibits cellular autophagy through the AMPK pathway, ultimately leading to radiosensitization. Mechanistically, LTF can directly interact with AMPK to facilitate its phosphorylation and activate autophagy signaling. Moreover, NEAT1 functions as a ceRNA that targets miR-214-5p resulting in an increased LTF expression. Intriguingly, SP2, a transcription factor regulated by AMPK, induced NEAT1 expression by directly binding to its promoter region and thus forming a LTF/AMPK/SP2/NEAT1/miR-214-5p feedback loop. Our work reveals for the first time that LTF induces radioresistance by promoting autophagy and enhancing its self-expression via forming a positive feedback loop, suggesting that LTF is an appealing radiosensitization target for treating LUSC.
SCALES AND DISTORTION CONSTANTS OF FOUR SOUTHERN TELESCOPES

Scales and distortion constants have been derived for the CTIO 4-m and 1.5-m and Las Campanas 2.5-m and 1-m telescopes with their correctors. The CTIO 4 m, as expected, is very similar to its KPNO counterpart, though the central scale (but not the distortion) at CTIO is slightly different from KPNO. At both 4-m telescopes the distortion is slightly color-dependent. The three smaller telescopes have much less, but still significant, distortion at their f/7.5 Ritchey-Chretien foci. Ray tracing of the published parameters of the Las Campanas telescopes with comparison to measures of plates from these telescopes shows that the published data apparently do not accurately describe the real telescopes. Some aspects of the problem of deriving positions for multiobject spectroscopy are discussed.
Re-examination of laminar flow over twin circular cylinders in tandem arrangement

Viscous fluid flow past two identical circular cylinders in a tandem arrangement is numerically investigated at a typical Reynolds number of 200. By considering a large span of spacing ratio (0.1 ⩽ G/D ⩽ 6.0) with a fine interval of 0.1 or less, the dependences on the spacing ratio of the drag force, lift force, lift fluctuation frequency, torque on the cylinder pair and phase difference between the lift fluctuations of the two cylinders are investigated in detail, where D is the diameter of the cylinder and G the surface-to-surface distance between the cylinders. The phase difference between the lift fluctuations of the two cylinders is addressed based on correlation analysis together with the phase diagram, which has received scarce attention before. The phase difference provides further understanding to the dependence of the wake evolutions behind the twin circular cylinders. The numerical investigations show that diverse regimes can be identified according to the dependence of the hydrodynamics on the spacing ratio. The hydrodynamic discontinuities at G/D = 0.9, which have previously been ignored, are reported in this work. The physical correlations between the hydrodynamic discontinuities and the wake patterns are presented.
Nonlinear Interaction of Soil--Pile in Horizontal Vibration

This paper presents a new model for analyzing a nonlinear soil–pile interaction subject to horizontal shaking of a vertical circular pile embedded in a soil layer of finite thickness. The pile rests on bedrock with either a pinned or a clamped support. The soil mass is assumed composing of a “semi-nonlinear” inner soil zone around the pile and a linear viscoelastic soil zone outside the inner zone. When the inner soil behaves linearly, the present solutions are identical to those obtained by Nogami and Novak in 1977. Numerical results show that soil resistance of less slender piles developed against the vibration is larger than that of more slender piles. Soil resistance depends more strongly on the size of the nonlinear inner zone when the pile is vibrating at a frequency higher than the natural frequency of the soil. Soil nonlinearity, in general, results in a smaller damping and stiffness of the soil–pile system, except at high frequency. At higher vibration frequency, the situation can be very complic.
The Impact of Race and Gender-Related Discrimination on the Psychological Distress Experienced by Junior Doctors in the UK: A Qualitative Secondary Data Analysis

Almost half of NHS doctors are junior doctors, while high proportions are women and/or Black, Asian, and Minority Ethnic (BAME) individuals. Discrimination against this population is associated with poorer career-related outcomes and unequal representation. We aimed to qualitatively explore junior doctors’ experience of workplace racial and gender-based discrimination, and its impact on their psychological distress (PD). In this study, we carried out a secondary analysis of data from a UK-based parent study about junior doctors’ working cultures and conditions. Interview data was examined using thematic analysis. Transcripts (n = 14) documenting experiences of race and/or gender-based discrimination were sampled and analysed from 21 in-depth interviews conducted with UK junior doctors. Four themes were generated about the experiences and perpetrators of discrimination, the psychological impact of discrimination, and organisational interventions that tackle discrimination. Discrimination in various forms was reported, from racially charged threats to subtle microaggressions. Participants experienced profoundly elevated levels of PD, feeling fearful, undermined, and under-confident. Discrimination is associated with elevated levels of PD, whilst negatively impacting workforce sustainability and retention. This reduces the opportunity for more diversity in NHS medical leadership. We encourage NHS hospitals to review their policies about discrimination and develop in-person workshops that focus on recognising, challenging, and reporting workplace discrimination.
The Water–Energy–Food Nexus in European Countries: A Review and Future Perspectives

The interaction between water, energy, and food as the water–energy–food (WEF) nexus has drawn much attention recently to solve upcoming uncertainty in food security. The aim of this study is to investigate the status of the WEF nexus in European countries. It is indicated that the largest nexus studies (among 27 European countries) have been conducted in Spain and Italy. It is confirmed that there is a large number of nexus studies in water-stressed countries while there are few studies on water-abundant countries (Slovakia and Luxembourg). Based on existing research, the majority of nexus studies focused on energy production. It is highlighted that most of the nexus studies were focused on water quantity aspects (rarely related to quality aspects) and energy; however, other resources including land, climate, ecosystem, soil, and environment received little attention. The migration of people as a result of climate change in the WEF nexus is not considered. Moreover, there is a lack of common and standard frameworks for nexus assessment. Therefore, we suggest a standard approach for nexus studies and produce a cross-sectoral and holistic approach for the evaluation of a water (quantity and quality)–energy–food–land–climate (WqEFLC) nexus that takes into consideration the circular economy.
Outcomes for children and adolescents with Juvenile idiopathic arthritis addressed by occupational therapy services in specialist rheumatology clinics in South Africa

Introduction: International guidelines for best practice indicate specialised treatment is required for Juvenile idiopathic arthritis (JIA). While occupational therapy intervention for functional limitations in this chronic condition is conditionally recommended, the extent to which this is provided in public specialist rheumatology clinics in South Africa is unknown. The aim of this study was to determine which needs related to outcomes for occupational performance or functional status, condition-related factors and health-related quality of life, reported by children and adolescents with JIA were addressed by current occupational therapy services. Methods: The study used two descriptive, quantitative studies with limited samples of 37 clients with JIA attending specialist rheumatology clinics and nine occupational therapists who currently provide intervention for clients with JIA. Results: Functional deficits reported by 30–63% of clients with JIA were increased symptoms of active disease and difficulties with school activities. Occupational therapy services addressed condition-related factors and participation in personal management but not many related to the social, educational and psychosocial needs of clients with JIA. Conclusion: Occupational therapy services followed international guidelines but based on the reductionist biomedical model approach used within specialist services in tertiary hospitals, which limit context-based therapy for children and adolescents with JIA in the community.
Electronic and Topological Properties of UIO66-ILs Interaction through a Computational Study

A high surface area adsorbent, such as MOFs, is an attractive option to evacuate heavy metals from wastewater. However, due to the possibility of the MOF structure collapsing when exposed to water, the stability and selectivity of MOFs for wastewater treatment remain a debatable task. Depending on the application, it has been shown that the consolidation of IL into MOF could improve the stability and reusability of pure MOF; nevertheless, research on the molecular interactions between the MOF framework and IL is still lacking. The stability, compatibility, and selectivity of this hybrid material are significantly influenced by the fundamental interactions between the MOFs and ILs moieties (cation and anion molecules), particularly the sorts of interactions. In this work, we focused on the topological properties of ILs and utilization of molecular docking calculations to assess the binding energy (ΔGbind) and binding affinity between UIO66 with TFSI-imidazole and TFSI-pyridinium ILs studied. The properties of ILs such as aromaticity of the structures, bond critical point (BCP), and electrostatic potential map surface were carried out using the Gaussian and Multiwfn software while the binding energies were computed using the AutoDock software to identify particular binding sites for IL toward MOF. The Autodock software's default setting was used to prepare all of the structures. To determine the binding locations of MOF, the IL was successively incorporated into the MOF pores inside the grid box of 90 x 90 x 90 Å (x, y, and z) dimensions. The results showed that both ILs; TFSI-imidazole, and TFSI-pyridinium IL, interacted favorably with the MOFs, having binding energies varying from -4.12 to -8.60 kcal mol-1. The stability of UIO66-ILs system increases with the addition of anion and cation. According to docking molecular structures, both cation and anion tend to bind in the corner of the MOF pore, which is in line with the previous work.
LIF Inhibits Proliferation of Esophageal Squamous Carcinoma Cells by Radiation Mediated Through JAK-STAT Signaling Pathway

Background: Esophagus cancer is a malignant tumor with a high incidence rate, and radiation is an important modality for esophageal cancer therapy. However, therapeutic failure in the treatment of ESCC is often attributed to an inherent radio-resistance of the tumor cells. This study discusses effect and mechanism of carbon ion exerts tumor-inhibiting proliferation via down-regulation of LIF in esophageal squamous cell carcinoma. Methods: Colony formation, CCK8 and EdU assays were used to detect cell survival and proliferation after 0 and 2Gy carbon ion irradiation of ECA109 cells. Proteomics changes were probed in response to carbon ion irradiation using quantitative proteomics approach incorporating TMT isotope tags. Then, candidate genes were identified via bioinformatics analysis methods and microarray results were verified by real-time qPCR. Paired ESCC tumor tissues and adjacent non-tumor samples from 17 patients were collected and used for detecting expression by immunohistochemistry. Furthermore, small interfering RNA (siRNA) was transfected into ECA109 and KYSE150 cells and cell proliferation was analyzed by EdU assay. Flow cytometry and Western blot were performed to measure the and apoptosis and JAK-STAT3 protein expression level of ECA109 and KYSE150 cells combined drugs after siLIF transfection. Results: When compared with the control (0Gy), Inhibition of ECA109 cell proliferation and clonogenic survival by 2 Gy carbon ions, radiation group screened 360 differentially expressed proteins, 156 of which were up-regulated and 144 were down-regulated. Downregulation of LIF expression by siRNA enhances apoptotic in the ECA109 and KYSE150 cells, significantly inhibited esophageal squamous cell carcinoma cells proliferation. In ESCC cells, the JAK/STAT3 signaling pathway is inhibited in a LIF-dependent manner, resulting in the expression of STAT3 downstream target genes. Carbon ions combined with siLIF inhibited cell proliferation more significantly. The inhibitory cell proliferation effect was more pronounced by the combined intervention of carbon ion irradiation with siLIF. LIF expression was 18.51±9.84 and 5.82±4.50 in 17 paired ESCC tissues and adjacent non-cancerous tissues, respectively. LIF protein expression was lower in ESCC than in the adjacent normal tissue. Conclusion: The findings of this study reveal that Carbon ion knockdown was shown to downregulate LIF in ESCC cells. LIF is involved in ESCC proliferation and inhibited the ESCC cell proliferation by activating the STAT3 signaling pathways.
Direct numerical simulation of turbulence in a nominally zero-pressure-gradient flat-plate boundary layer

A nominally-zero-pressure-gradient incompressible boundary layer over a smooth flat plate was simulated for a continuous momentum thickness Reynolds number range of 80 ≤ Reθ ≤ 940. Transition which is completed at approximately Reθ = 750 was triggered by intermittent localized disturbances arising from patches of isotropic turbulence introduced periodically from the free stream at Reθ = 80. Streamwise pressure gradient is quantified with several measures and is demonstrated to be weak. Blasius boundary layer is maintained in the early transitional region of 80 < Reθ < 180 within which the maximum deviation of skin friction from the theoretical solution is less than 1%. Mean and second-order turbulence statistics are compared with classic experimental data, and they constitute a rare DNS dataset for the spatially developing zero-pressure-gradient turbulent flat-plate boundary layer. Our calculations indicate that in the present spatially developing low-Reynolds-number turbulent flat-plate boundary layer, total shear stress mildly overshoots the wall shear stress in the near-wall region of 2–20 wall units with vanishing normal gradient at the wall. Overshoots as high as 10% across a wider percentage of the boundary layer thickness exist in the late transitional region. The former is a residual effect of the latter. The instantaneous flow fields are vividly populated by hairpin vortices. This is the first time that direct evidence (in the form of a solution of the Navier–Stokes equations, obeying the statistical measurements, as opposed to synthetic superposition of the structures) shows such dominance of these structures. Hairpin packets arising from upstream fragmented Λ structures are found to be instrumental in the breakdown of the present boundary layer bypass transition.
Packaging waste and recycle in EU

Nowadays, the use of plastic is very widespread, especially in packaging materials. Most packaging materials are made from fossil-based polymers, which contribute significantly to greenhouse gas emissions. The unprecedented leakage of single-use plastic waste into the environment is a major problem, with negative impacts on both ecosystems and human health. In this study we examine the development of packaging waste and recycled packaging in the European Union over a period of more than 20 years, highlighting changes in the regulatory context; assess the achievements of Hungary so far and forecast the expected developing of packaging volumes and recycling rates; and consider recycling and waste reduction options, including alternative sustainable packaging options. Our forecast based on the evidence shows that Hungary (47.62%), Germany (61.46%), Malta (26.27%), Romania (58.64%) and Croatia (49.41%) are not expected to reach the target set (65% by 2025) in EU legislation. Out of the 27 countries surveyed, 6 (Belgium 88.2%, the Netherlands 87.81%, Luxembourg 76.96%, the Czech Republic 77.79%, Finland 78.75% and Denmark 83.7%) exceeded the expectations, so we show their waste management and waste recycling good practice, as they can serve as good examples for Hungary and other countries.