Miracle-dz/UniFAR-FTUs huggingface dataset:
THE HETDEX PILOT SURVEY. II. THE EVOLUTION OF THE Lyα ESCAPE FRACTION FROM THE ULTRAVIOLET SLOPE AND LUMINOSITY FUNCTION OF 1.9

We study the escape of Lyα photons from Lyα emitting galaxies (LAEs) and the overall galaxy population using a sample of 99 LAEs at 1.9 < z < 3.8 detected through integral-field spectroscopy of blank fields by The Hobby Eberly Telescope Dark Energy Experiment Pilot Survey. For 89 LAEs with broadband counterparts we measure ultraviolet (UV) luminosities and UV slopes, and estimate E(B − V) under the assumption of a constant intrinsic UV slope for LAEs. These quantities are used to estimate dust-corrected star formation rates (SFRs). Comparison between the observed Lyα luminosity and that predicted by the dust-corrected SFR yields the Lyα escape fraction. We also measure the Lyα luminosity function and luminosity density (ρLyα) at 2 < z < 4. Using this and other measurements from the literature at 0.3 < z < 7.7 we trace the redshift evolution of ρLyα. We compare it to the expectations from the star formation history of the universe and characterize the evolution of the Lyα escape fraction of galaxies. LAEs at 2 < z < 4 selected down to a luminosity limit of L(Lyα) > (3–6) × 1042 erg s−1 (0.25–0.5 L*), have a mean 〈E(B − V)〉 = 0.13 ± 0.01, implying an attenuation of ∼70% in the UV. They show a median UV uncorrected SFR = 11 M☉ yr−1, dust-corrected SFR = 34 M☉ yr−1, and Lyα equivalent widths (EWs) which are consistent with normal stellar populations. We measure a median Lyα escape fraction of 29%, with a large scatter and values ranging from a few percent to 100%. The Lyα escape fraction in LAEs correlates with E(B − V) in a way that is expected if Lyα photons suffer from similar amounts of dust extinction as UV continuum photons. This result implies that a strong enhancement of the Lyα EW with dust, due to a clumpy multi-phase interstellar medium (ISM), is not a common process in LAEs at these redshifts. It also suggests that while in other galaxies Lyα can be preferentially quenched by dust due to its scattering nature, this is not the case in LAEs. We find no evolution in the average dust content and Lyα escape fraction of LAEs from z ∼ 4 to 2. We see hints of a drop in the number density of LAEs from z ∼ 4 to 2 in the redshift distribution and the Lyα luminosity function, although larger samples are required to confirm this. The mean Lyα escape fraction of the overall galaxy population decreases significantly from z ∼ 6 to z ∼ 2, in agreement with recent results. Our results point toward a scenario in which star-forming galaxies build up significant amounts of dust in their ISM between z ∼ 6 and 2, reducing their Lyα escape fraction, with LAE selection preferentially detecting galaxies which have the highest escape fractions given their dust content. The fact that a large escape of Lyα photons is reached by z ∼ 6 implies that better constraints on this quantity at higher redshifts might detect re-ionization in a way that is uncoupled from the effects of dust.
Effects of the quark-hadron phase transition on highly magnetized neutron stars

The presence of quark-hadron phase transitions in neutron stars can be related to several interesting phenomena. In particular, previous calculations have shown that fast rotating neutron stars, when subjected to a quark-hadron phase transition in their interiors, could give rise to the backbending phenomenon characterized by a spin-up era. In this work, we use an equation of state composed of two phases, containing nucleons (and leptons) and quarks. The hadronic phase is described in a relativistic mean field formalism that takes many-body forces into account, and the quark phase is described by the MIT bag model with a vector interaction. Stationary and axi-symmetric stellar models are obtained in a self-consistent way by solving numerically the Einstein-Maxwell equations by means of a pseudo-spectral method. As a result, we obtain the interesting backbending phenomenon for fast spinning neutron stars. More importantly, we show that a magnetic field, which is assumed to be axi-symmetric and poloidal, can also be enhanced due to the phase transition from normal hadronic matter to quark matter on highly magnetized neutron stars. Therefore, in parallel to the spin-up era, classes of neutron stars endowed with strong magnetic fields may go through a "magnetic-up era" in their lives.
Evolution of a proto-neutron star with a nuclear many-body equation of state: Neutrino luminosity and gravitational wave frequencies

This work has been partially supported by “NewCompStar,” COST Action MP1304, by the H2020-MSCA-RISE-2015 Grant No. StronGrHEP-690904, by INFN (through grant TEONGRAV), and supported in part by the U.S. Department of Energy, Office of Science, Office of Nuclear Physics, under Contract No. DE-AC02-06CH11357 (A. L.). J. A. P. acknowledges support by the Spanish MINECO Grant No. AYA2015-66899-C2-2-P.
Conformal consistency relations for single-field inflation

We generalize the single-field consistency relations to capture not only the leading term in the squeezed limit — going as 1/q3, where q is the small wavevector — but also the subleading one, going as 1/q2. This term, for an (n+1)-point function, is fixed in terms of the variation of the n-point function under a special conformal transformation; this parallels the fact that the 1/q3 term is related with the scale dependence of the n-point function. For the squeezed limit of the 3-point function, this conformal consistency relation implies that there are no terms going as 1/q2. We verify that the squeezed limit of the 4-point function is related to the conformal variation of the 3-point function both in the case of canonical slow-roll inflation and in models with reduced speed of sound. In the second case the conformal consistency conditions capture, at the level of observables, the relation among operators induced by the non-linear realization of Lorentz invariance in the Lagrangian. These results mean that, in any single-field model, primordial correlation functions of ζ are endowed with an SO(4,1) symmetry, with dilations and special conformal transformations non-linearly realized by ζ. We also verify the conformal consistency relations for any n-point function in models with a modulation of the inflaton potential, where the scale dependence is not negligible. Finally, we generalize (some of) the consistency relations involving tensors and soft internal momenta.
Hydroxypropyl chitosan nail lacquer of ciclopirox-PLGA nanocapsules for augmented in vitro nail plate absorption and onychomycosis treatment

Abstract Onychomycosis accounts for 90% of nail infections worldwide. Topical therapy provides localized effects with minimal adverse systemic actions, yet its effectiveness is limited by minimal drug permeation through the keratinized nail plate. Ciclopirox (CIX) is a FDA-approved broad-spectrum antimycotic agent. However, the complete cure with its nail lacquer (8% w/v) may continue for one year with a high cost. Therefore, poly lactide-co-glycolide (PLGA) nanocapsules (NCs) of CIX were prepared by nanoprecipitation and optimized through a 23 factorial design to be incorporated into hydroxypropyl chitosan (HPCH) based nail lacquer. Nail hydration, in vitro nail absorption, minimum inhibitory concentration (MIC), inhibition zones and ex vivo fungal growth on nail fragments were evaluated. The optimized NCs of CIX based on 100 mg PLGA 2 A and lipoid S75 showed a mean diameter of 174.77 ± 7.90 nm, entrapment efficiency (EE%) of 90.57 ± 0.98%, zeta potential (ZP) of −52.27 ± 0.40 mV and a prolonged drug release. Nail lacquer of the optimized NCs exhibited a higher stability than NCs dispersion. Compared to CIX solution (1% w/v), the respective decrease in MIC for NCs and their lacquer was four- and eight-fold. The lacquer superiority was confirmed by the enhancement in the nail hydration and absorption by 4 and 2.60 times, respectively, relative to CIX solution and the minimal ex vivo fungal growth. Therefore, HPCH nail lacquer of (1% w/v) CIX-PLGA-NCs can be represented as a potential topical delivery system for enhanced in vitro nail absorption and therapeutic efficacy against onychomycosis at a low dose.
Laparoscopic versus open liver resection for intrahepatic cholangiocarcinoma: a multicenter propensity score-matched study

Abstract Background The role of laparoscopy in the treatment of intrahepatic cholangiocarcinoma (ICC) remains unclear. This multicenter study examined the outcomes of laparoscopic liver resection for ICC. Methods Patients with ICC who had undergone laparoscopic or open liver resection between 2012 and 2019 at four European expert centers were included in the study. Laparoscopic and open approaches were compared in terms of surgical and oncological outcomes. Propensity score matching was used for minimizing treatment selection bias and adjusting for confounders (age, ASA grade, tumor size, location, number of tumors and underlying liver disease). Results Of 136 patients, 50 (36.7%) underwent laparoscopic resection, whereas 86 (63.3%) had open surgery. Median tumor size was larger (73.6 vs 55.1 mm, p = 0.01) and the incidence of bi-lobar tumors was higher (36.6 vs 6%, p < 0.01) in patients undergoing open surgery. After propensity score matching baseline characteristics were comparable although open surgery was associated with a larger fraction of major liver resections (74 vs 38%, p < 0.01), lymphadenectomy (60 vs 20%, p < 0.01) and longer operative time (294 vs 209 min, p < 0.01). Tumor characteristics were similar. Laparoscopic resection resulted in less complications (30 vs 52%, p = 0.025), fewer reoperations (4 vs 16%, p = 0.046) and shorter hospital stay (5 vs 8 days, p < 0.01). No differences were found in terms of recurrence, recurrence-free and overall survival. Conclusion Laparoscopic resection seems to be associated with improved short-term and with similar long-term outcomes compared with open surgery in patients with ICC. However, possible selection criteria for laparoscopic surgery are yet to be defined.
TIME-RESOLVED EMISSION FROM BRIGHT HOT PIXELS OF AN ACTIVE REGION OBSERVED IN THE EUV BAND WITH SDO/AIA AND MULTI-STRANDED LOOP MODELING

Evidence of small amounts of very hot plasma has been found in active regions and might be an indication of impulsive heating released at spatial scales smaller than the cross-section of a single loop. We investigate the heating and substructure of coronal loops in the core of one such active region by analyzing the light curves in the smallest resolution elements of solar observations in two EUV channels (94 and 335 Å) from the Atmospheric Imaging Assembly on board the Solar Dynamics Observatory. We model the evolution of a bundle of strands heated by a storm of nanoflares by means of a hydrodynamic 0D loop model (EBTEL). The light curves obtained from a random combination of those of single strands are compared to the observed light curves either in a single pixel or in a row of pixels, simultaneously in the two channels, and using two independent methods: an artificial intelligent system (Probabilistic Neural Network) and a simple cross-correlation technique. We explore the space of the parameters to constrain the distribution of the heat pulses, their duration, their spatial size, and, as a feedback on the data, their signatures on the light curves. From both methods the best agreement is obtained for a relatively large population of events (1000) with a short duration (less than 1 minute) and a relatively shallow distribution (power law with index 1.5) in a limited energy range (1.5 decades). The feedback on the data indicates that bumps in the light curves, especially in the 94 Å channel, are signatures of a heating excess that occurred a few minutes before.
Effect of exoskeleton manipulator on hand function rehabilitation for postburn patients

Abstract Purpose Patients with scar contracture deformities caused by hand burns were treated with an exoskeleton manipulator system, which was equipped with games to explore its clinical application value. Methods Twenty patients who were treated for post-burn scars of bilateral hands between October 2020 and June 2021 were selected (ChiCTR2000036232). The patients were divided into two groups: control, 10 patients (traditional outpatient treatment); and experimental, 10 patients (exoskeleton manipulator system treatment). We compared the change in the total active motion (TAM) value, grip strength, scar improvement, and postoperative pain improvement. Results After 3 months of rehabilitation training, the improvement of thumb TAM was 33.80 ± 11.38 ° in the experimental group and 23.2 ± 6.13 ° in the control group. With respect to the index finger TAM, the improvement in the experimental and control groups was 84.50 ± 30.96 ° and 54.80 ± 15.89 °, respectively. The middle finger TAM of the experimental and control groups improved by 86.75 ± 32.85 ° and 60.25 ± 17.97 °, respectively. However, improvement of grip strength, scar score, and pain score were similar between the two groups. Conclusions The exoskeleton manipulator system has excellent effects in improving burned hand joint movement, which is suitable for hand burn patients and has beneficial clinical effects. Implications for rehabilitation Exercise is an effective means to improve the hand function of burn patients. The application of mechanical devices in the rehabilitation of burned hands can effectively help patients exercise. The A5 Hand Function Training System is an exoskeleton mechanical device that can exercise the small joints of the hand. It assists patients in using different computer games during treatment.
Chemical modification of acellular fish skin as a promising biological scaffold by carbodiimide cross‐linker for wound healing

Biological matrices can be modified with cross‐linkers to improve some of their characteristics as scaffolds for tissue engineering. In this study, chemical cross‐linker 1‐Ethyl‐3‐(3‐dimethylaminopropyl) carbodiimide (EDC) was used with different ratios (5, 10, 20, 30, and 40 mM) to improve properties such as mechanical strength, denaturation temperature, and degradability of the acellular fish skin as a biological scaffold for tissue engineering applications. Morphological analysis showed that the use of cross‐linker at low concentrations had no effect on the structure and textiles of the scaffold, while increasing mechanical strength, denaturation temperature, and degradation time. Cytotoxicity and cellular studies showed that the optimal cross‐linker concentration did not significantly affect cell viability as well as cell adhesion. In general, utilising the carbodiimide cross‐linker with the optimal ratio can improve the characteristics and function of the biological tissues such as acellular fish skin.
Expanded haloes, abundance matching and too-big-to-fail in the Local Group

Observed kinematical data of 40 Local Group (LG) members are used to derive the dark matter halo mass of such galaxies. Haloes are selected from the theoretically expected LG mass function and two different density profiles are assumed, a standard universal cuspy model and a mass dependent profile which accounts for the effects of baryons in modifying the dark matter distribution within galaxies. The resulting relations between stellar and halo mass are compared with expectations from abundance matching. Using a universal cuspy profile, the ensemble of LG galaxies is fit in relatively low mass haloes, leaving "dark" many massive haloes of \mhalo$\gtrsim$10$^{10}$\msun: this reflects the "too big to fail" problem and results in a \mstar-\mhalo\ relation that differs from abundance matching predictions. Moreover, the star formation efficiency of isolated LG galaxies increases with decreasing halo mass when adopting a cuspy model. By contrast, using the mass dependent density profile, dwarf galaxies with \mstar$\gtrsim$10$^{6}$\msun are assigned to more massive haloes, which have a central cored distribution of dark matter: the "too big to fail" problem is alleviated, the resultant \mstar-\mhalo\ relation follows abundance matching predictions down to the completeness limit of current surveys, and the star formation efficiency of isolated members decreases with decreasing halo mass, in agreement with theoretical expectations. Finally, the cusp/core space of LG galaxies is presented, providing a framework to understand the non-universality of their density profiles.
Measure Concentration and the Topology of Positively-Curved Riemannian Manifolds

In this paper, I shall demonstrate that sufficiently high-dimensional closed positively-curved Riemannian manifolds are either diffeomorphic to a spherical space form, or isometric to a locally compact rank one symmetric space. This surprising classification of positively-curved Riemannian manifolds results from combining the concentration of measures of Grassmanians with Brendle-Schoen pointwise (weakly)- 1/4-pinching Theorem. A direct corollary of the main result within this paper is the answering of the long standing Hopf Conjecture in sufficiently high dimensions.
Detection of brown adipose tissue in rats with acute cold stimulation using quantitative susceptibility mapping

To the Editor : Adipose tissue occurs in at least two different entities in mammals and humans: brown adipose tissue (BAT) and white adipose tissue (WAT). BAT is characterized by a unique uncoupling protein 1 (UCP1) in the mitochondria that enables the uncoupling of the respiratory chain from adenosine triphosphate synthesis. Thus, energy is dissipated as heat to reduce fat accumulation. BAT is also considered a highly heterogeneous tissue with abundant oxygen, blood supply, and iron-rich mitochondria. [1,2] Activation of BAT via exposure to a cold environment is considered to be a means of reducing triglycerides to ﬁ ght obesity. [3] The alterations in cells and tissues of activated BAT include increased iron content and UCP1 expression in mitochondrial, blood perfusion, and lipid utilization. [4] Therefore, accurate identi ﬁ cation and quantitative analysis of inactive and activated BAT are of great signi ﬁ cance for the treatment of metabolic diseases that target BAT, such as obesity. Owing to the iron-rich mitochondria in BAT, [5] we tested our hypothesis that quantitative susceptibility mapping (QSM) could be a promising method for monitoring BAT activation in
X-ray radiation of the jets and the supercritical accretion disk in SS 433

Abstract The observed X-ray luminosity of SS 433 is ~1036 erg/s, it is known that all the radiation is formed in the famous SS 433 jets. The bolometric luminosity of SS 433 is ~1040 erg/s, and originally the luminosity must be realized in X-rays. The original radiation is probably thermalized in the supercritical accretion disk wind, however the missing more than four orders of magnitude is surprising. We have analysed the XMM-Newton spectra of SS 433 using a model of adiabatically and radiatively cooling X-ray jets. The multi-temperature thermal jet model reproduces very well the strongest observed emission lines, but it can not reproduce the continuum radiation and some spectral features. We have found a notable contribution of ionized reflection to the spectrum in the energy range from ~3 to 12 keV. The reflected spectrum is an evidence of the supercritical disk funnel, where the illuminating radiation comes from deeper funnel regions, to be further reflected in the outer visible funnel walls (r ≥ 2 ⋅ 1011 cm). The illuminating spectrum is similar to that observed in ULXs, its luminosity has to be no less than ~1039 erg/s. A soft excess has been detected, that does not depend on the thermal jet model details. It may be represented as a BB with a temperature of Tbb ≈ 0.1 keV and luminosity of Lbb~3 ⋅ 1037 erg/s. The soft spectral component has about the same parameters as those found in ULXs.
Adaptation to distinct habitats is maintained by contrasting selection at different life stages in sunflower ecotypes.

Conspecific populations living in adjacent but contrasting microenvironments represent excellent systems for studying natural selection. These systems are valuable because gene flow is expected to force genetic homogeneity except at loci experiencing divergent selection. A history of reciprocal transplant and common garden studies in such systems, and a growing number of genomic studies, have contributed to understanding how selection operates in natural populations. While selection can vary across different fitness components and life stages, few studies have investigated how this ultimately affects allele frequencies and the maintenance of divergence between populations. Here, we study two sunflower ecotypes in distinct, adjacent habitats by combining demographic models with genome-wide sequence data to estimate fitness and allele frequency change at multiple life stages. This framework allows us to estimate that only local ecotypes are likely to experience positive population growth (λ>1) and that the maintenance of divergent adaptation appears to be mediated via habitat- and life stage-specific selection. We identify genetic variation, significantly driven by loci in chromosomal inversions, associated with different life history strategies in neighbouring ecotypes that optimize different fitness components and may contribute to the maintenance of distinct ecotypes.
Electron Transfer Route between Quinones in Type-II Reaction Centers

In photosynthetic reaction centers from purple bacteria (PbRCs) and photosystem II (PSII), the photoinduced charge separation is terminated by an electron transfer between the primary (QA) and secondary (QB) quinones. Here, we investigate the electron transfer route, calculating the superexchange coupling (HQA–QB) for electron transfer from QA to QB in the protein environment. HQA–QB is significantly larger in PbRC than in PSII. In superexchange electron tunneling, the electron transfer via unoccupied molecular orbitals of the nonheme Fe complex (QA → Fe → QB) is pronounced in PbRC, whereas the electron transfer via occupied molecular orbitals (Fe → QB followed by QA → Fe) is pronounced in PSII. The significantly large HQA–QB is caused by a water molecule that donates the H-bond to the ligand Glu-M234 in PbRC. The corresponding water molecule is absent in PSII due to the existence of D1-Tyr246. HQA–QB increases in response to the Ser-L223···QB H-bond formation caused by an extension of the H-bond network, which facilitates charge delocalization over the QB site. This explains the observed discrepancy in the QA-to-QB electron transfer between PbRC and PSII, despite their structural similarity.