Miracle-dz/UniFAR-FTUs huggingface dataset:
Identifying barriers to report adverse drug reactions using the Delphi method: Experience from an institute of national importance of India

Background: Spontaneous reporting of suspected adverse drug reaction (ADR) is an essential component of pharmacovigilance program, however, under reporting is a major drawback of it. Medical professionals cite many reasons for their inability to report suspected ADRs. Objective: This study aimed to seek consensus among resident doctors regarding barriers to report ADRs. Method: A two-round Delphi consensus study was conducted among resident doctors of a tertiary care institute of India. The participants used a five-point Likert scale to indicate each question of an initial questionnaire whether it should be considered a barrier for reporting ADR. The items for which ≥80% of all respondents agreed or strongly agreed were accepted as barrier for reporting ADR. Results: Forty-five participants completed the Delphi survey. Out of 25 questions participants unanimously selected 9 items such as unavailability of reporting form, complexity in filling reporting form and lack of motivation as barriers for reporting ADR. Conclusion: Using a Delphi method, this study identified a set of statements perceived as barriers by participants for reporting ADR
Preservation of Features of Anatomical Polymorphism of Deschampsia antarctica É. Desv. (Poaceae) During In Vitro Clonal Reproduction

We studied the anatomical features of the leaf structure of Deschampsia antarctica É. Desv. (Poaceae) obtained from seeds collected from different habitats of the maritime Antarctic. These plants have been maintained in culture in vitro for more than 7 years. The plants include stable chromosome forms comprising diploids (2 n = 26), a diploid plant with B-chromosomes (2 n = 26 + 0–3B), a triploid with rearranged chromosome morphology, and myxoploids with different ratios of diploid and nondiploid cells in the root meristem. The D. antarctica plants that were studied generally had a similar anatomical structure in culture in vitro and in nature. At the same time, plants of different cultivated genotypes also displayed their own leaf structure features. In particular, qualitative features included asymmetric four-ribs and five-rib leaves instead of typical three-rib leaves for some genotypes, some individuals characterized by the presence of unicellular nonglandular pointed trichomes on an adaxial side, differences in vascular bundle sheath, and other features. No clear dependence of the anatomical structural features on the chromosomal status of the studied genotypes was evident. At the same time, differences were evident in traits that included the number of stomata, thickness of the outer cell walls of the epidermis, bundles sheath state, number of leaf ribs, and the persistent presence of trichomes under prolonged in vitro cloning. The findings indicate that D. antarctica plants collected from different locations of the maritime Antarctic for long-term cultivation in vitro under standard cultivation conditions retain the anatomical characteristics of the wild plants. The polymorphism of in vitro-cultivated plants is not related to the polymorphism of their karyotype, but is apparently due to the heterogeneity of the original plants and possibly the epigenetic fixation of a number of anatomical features produced in the natural microhabitats of D. antarctica populations.
Recombinant Human HPS Protects Mice and Nonhuman Primates from Acute Liver Injury

Acute liver injury shares a common feature of hepatocytes death, immune system disorders, and cellular stress. Hepassocin (HPS) is a hepatokine that has ability to promote hepatocytes proliferation and to protect rats from D-galactose (D-Gal)- or carbon tetrachloride (CCl4)-induced liver injury by stimulating hepatocytes proliferation and preventing the high mortality rate, hepatocyte death, and hepatic inflammation. In this paper, we generated a pharmaceutical-grade recombinant human HPS using mammalian cells expression system and evaluated the effects of HPS administration on the pathogenesis of acute liver injury in monkey and mice. In the model mice of D-galactosamine (D-GalN) plus lipopolysaccharide (LPS)-induced liver injury, HPS treatment significantly reduced hepatocyte death and inflammation response, and consequently attenuated the development of acute liver failure. In the model monkey of D-GalN-induced liver injury, HPS administration promoted hepatocytes proliferation, prevented hepatocyte apoptosis and oxidation stress, and resulted in amelioration of liver injury. Furthermore, the primary pharmacokinetic study showed natural HPS possesses favorable pharmacokinetics; the acute toxicity study indicated no significant changes in behavioral, clinical, or histopathological parameters of HPS-treated mice, implying the clinical potential of HPS. Our results suggest that exogenous HPS has protective effects on acute liver injury in both mice and monkeys. HPS or HPS analogues and mimetics may provide novel drugs for the treatment of acute liver injury.
A Novel Cooperative Network Using Down-link Non-orthogonal Multiple Access Scheme

A novel downlink cooperative non-orthogonal multiple access (DC-NOMA) scheme is proposed in this paper to achieve higher performance in the spectral efficiency compared to the classical NOMA schemes. The communication system consists of one base station and two users (e.g., strong user and weak user). In down link phase, the base station transmits a superimposed signal to both users, and in the cooperative phase, the weak user sends its decoded message to the strong user. The main idea is how the weak user can help the strong user to improve the performance of both users. This occurs by enabling the weak user to perform a cooperative transmission with the strong user during the cooperative phase. The outage probability, outage throughput, and diversity order are derived and analyzed. Numerical results are provided to show that the spectral efficiency gain achieved through our proposed scheme is better than the conventional cooperative NOMA schemes.
Good to Be Home? Time‐Use and Satisfaction Levels Among Home‐Based Teleworkers

Home‐based teleworking (HbTW) has the potential to provide significant benefits to both employer and employee, but also presents considerable challenges. This paper considers HbTW among UK employees, specifically exploring distinctions in the time‐use of men and women home‐based teleworkers and the impacts of HbTW on employee satisfaction levels, using cross‐section fixed effects panel regression analysis of the British Household Panel Survey. Findings reveal that total time‐use in work activities among men and women home‐based teleworkers is relatively comparable, but the distribution significantly different. For women, housework represents a particular time constraint, reflecting continued presence of the ‘double‐shift’. Homeworkers report greater levels of satisfaction, yet they are more pronounced in respect to paid work than leisure time. Extensive hours of housework reported among women may explain these differences. Nevertheless, home‐based teleworkers report greater levels of satisfaction than other workers, suggesting considerable benefits especially for working mothers.
Convergent Evidence Supports TH2LCRR as a Novel Asthma Susceptibility Gene.

Asthma is a common complex disease with apparent genetic predispositions, and previous genome-wide association studies suggest that rs1295686 within the IL13 (interleukin 13) gene is significantly associated with asthma. Analysis of the data provided by the 1000 Genomes Project indicated that there are additional four SNPs in nearly complete linkage disequilibrium with rs1295686 in Caucasians. However, the causal SNPs and the associated mechanism remain unclear. To investigate this issue, functional genomics approaches were utilized to analyze the functions of these SNPs. Dual-luciferase assays indicated that the functional SNP is not rs1295686 but a haplotype consisting of other three SNPs, rs1295685, rs848 and rs847. Through chromosome conformation capture, it was found that the enhancer containing the three functional SNPs interacts with the promoter of TH2LCRR (T helper type 2 locus control region associated RNA), a recently identified long non-coding RNA. RNA-seq data analysis indicated that TH2LCRR expression is significantly increased in asthma patients and is dependent on the genotype at this locus, indicating that TH2LCRR is a novel susceptibility gene for asthma and that these SNPs confer asthma risk by regulating TH2LCRR expression. By chromatin immunoprecipitation, the related transcription factors that bind in the region surrounding these three SNPs were identified, and their interactions were investigated by functional genomics approaches. Our effort identified a novel mechanism through which genetic variations at this locus could influence asthma susceptibility.
Water Requirements and Crop Coefficients of Drip-irrigated Strawberry Plants

Studies were conducted for three production seasons between 1988 and 1991 to measure water use of drip- irrigated strawberry plants and to evaluate the effects of soil tension management level on fruit yield and drip irrigation water requirement. Water balance lysimeters were designed and installed to measure monthly water requirements of drip- irrigated strawberry plants. Drip-irrigated strawberry plots that were established next to the lysimeter facility used tensiometers to schedule irrigations with treatment management levels of 5, 10, and 15 kPa of soil tension.
PERFORMANCE ANALYSIS OF 100 M FREESTYLE SWIMMERS WITH VISUAL IMPAIRMENT AT THE 1996 PARALYMPIC GAMES

INTRODUCTION Classification has long been an accepted practice in sport, intended to provide fair competition by grouping athletes according to variables such as age, weight, and gender. In the case of athletes with a disability, classification is essential for the very existence of sports (Sherrill et al.,1986). Over the years, however, there has been heated debate regarding the definition and fairnessof athlete classification in disability sport (Richter et al., 1992; Weiss & Curtis, 1986). International competition for visually impaired swimmers is divided into three classes (Bl, B2, B3) base on visual acuity, visual field and light perception. Little scientific evidence is available regarding the relationship between visual classification and actual swimming performance parameters, and it has been argued that such classifications are unnecessary. To further examine this issue, an extensive investigation was conducted at the 1996 Atlanta Summer Paralympic Games. METHODS Swim performance data was collected for all male and female l00m freestyle swimmersin classes B1, B2 and B3. Performances were recorded using static video suweillance cameras placed at specified locations along the pool side (7.5, 10, 25.42.5m from the start). Camera data was fed to a video recorder via a central control panel and video recordings (30 fps) of the camera data were embedded with a time code from the official timing system. All events were analyzed in 25 metre segments and included identification of the following swim performance variables: clean swim speed, stroke rate, stroke length, start, turn and finish times. To determine if differences existed between the classes a separate multivariate analysis of variance (MANOVA) was run for both males and females, followed by appropriate post hoc tests. RESULTS AND DISCUSSION The overall multivariate tests were found to be significant (p=.05) for both males andfemales. The female swim performances showed significant differences between all three classes on clean swim speed, turn time, and finish time. No significant difference in stroke length were identified between the classes for either males or females. No significant differences in any of the performance variables were found for males between classes B2 and B3. The similarity between the B2 and B3 male swimmers may indicate that such a split between classes is unnecessary. REFERENCES Richter, K.J., Adams-Mushett, C. , Ferrara, M.S. & McCann, B.C. (1992). Integrated swimming classification: A faulted system. Adapted Physical Activity Quarterly, 9.5-13. Sherrill, C. , Adam-Mushett, C. & Jones, J.A. (1986). Classification and other issues in sports for the blind, cerebral palsied, les autures, and amputee athlete. In C. Sherrill (Ed.),Spoq and Disabled Athletes (pp. 93-100). Champaign, IL: Humm Kinetics. Weiss, M. and Curtis, K.A. (1986). Controversies in medical classification of wheelchair athletes. In C. S h e d (Ed.), Sport and disabled athletes (pp. 93-100). Champaign, IL: Human Kinetics.
The Development of Online Active Learning Management with Application for Pre-service Teachers

The technological breakthrough grows rapidly and plays an important role in our daily life. It is allowed people to communicate with teachers, instructors, students, and friends. Thus, learning management between teachers and students should be adjusted by using a variety of technical materials to support their learning ability. The purposes of this study were to develop online active learning management with application for pre-service teacher. The participants were 30 Early Childhood students, Suan Sunundha Rajabhat University. The findings revealed that the online learning efficiency was 88.06/85.67. The experimental outcome reveals that learning achievement is significantly different from before the use of online learning, at the statistical level of 0.05. After applying the online learning in the classroom, learning retention dropped down not less than 20%. The results can be concluded that the participants have learning retention after the use of the online learning.
Characterization of Pterotylenchus cecidogenus in Desmodium ovalifolium cover crop from oil palm plantations in central Colombia

Abstract Until recently, the stem gall nematode Pterotylenchus cecidogenus was only registered in eastern Colombia. However, the disease has recently been observed in central Colombian oil palm plantations that use Desmodium ovalifolium as a cover crop. Soil, root, stem, and leaf samples were collected from D. ovalifolium. Plants showed foliar yellowing, leaf drying, and galls within stem nodes. Nematodes were identified, and the distribution, population density, and relative importance of different genera were determined. We performed morphometric and molecular identification of nematodes associated with gall symptoms. The D2-D3 segment of the large subunit-28S of ribosomal ribonucleic acid (RNA) and internal transcribed spacer (ITS) was sequenced, and phylogenetic analysis was performed. P. cecidogenus mainly occurred in the galls and to a lesser extent in the roots and soil. Nematodes were not found in leaf or inflorescence tissue. Morphological and morphometric data confirm the presence of P. cecidogenus in the stems of D. ovalifolium with gall symptoms. This study is the first to report deoxyribonucleic acid (DNA) sequences of P. cecidogenus. Based on D2-D3 and ITS partial sequences, P. cecidogenus is a sister species of the leaf-galling nematode Ditylenchus phyllobius (Sinm. Orrina phyllobia).
Real‐time insect tracking and monitoring with computer vision and deep learning

Insects are declining in abundance and diversity, but their population trends remain uncertain as insects are difficult to monitor. Manual methods require substantial time investment in trapping and subsequent species identification. Camera trapping can alleviate some of the manual fieldwork, but the large quantities of image data are challenging to analyse. By embedding the image analyses into the recording process using computer vision techniques, it is possible to focus efforts on the most ecologically relevant image data. Here, we present an intelligent camera system, capable of detecting, tracking, and identifying individual insects in situ. We constructed the system from commercial off‐the‐shelf components and used deep learning open source software to perform species detection and classification. We present the Insect Classification and Tracking algorithm (ICT) that performs real‐time classification and tracking at 0.33 frames per second. The system can upload summary data on the identity and movement track of insects to a server via the internet on a daily basis. We tested our system during the summer 2020 and detected 2994 insect tracks across 98 days. We achieved an average precision of 89% for correctly classified insect tracks of eight different species. This result was based on 504 manually verified tracks observed in videos during 10 days with varying insect activities. Using the track data, we could estimate the mean residence time for individual flower visiting insects within the field of view of the camera, and we were able to show a substantial variation in residence time among insect taxa. For honeybees, which were most abundant, residence time also varied through the season in relation to the plant species in bloom. Our proposed automated system showed promising results in non‐destructive and real‐time monitoring of insects and provides novel information about phenology, abundance, foraging behaviour, and movement ecology of flower visiting insects.
Temperature Distribution of a Low Temperature Heat Pipe with Multiple Heaters for Electronic Cooling

A numerical study has been performed to predict the characteristics on the transient operation of the heat pipe with multiple heaters for electronic cooling. The model of the heat pipe was composed of the evaporator section with four heaters, insulated transport section, and the condensor section with a conductor which is cooled with uniform heat flux condition to surrounding. The governing equations and the boundary conditions were solved by the generalized PHOENICS computational code employing the finite volume method. Two test cases are investigated in present study; Case 1 indicates that the 1st and 2nd heaters among four heating sources are heated off, while the 3rd and 4th heaters are heated on. Case 2 is the inverse situation switched from heating location of Case 1. The results show that the transient time to reach the steady state is shorter for Case 1 than for Case 2. Especially, the temperature difference of the heater during switching operation is relatively small compared to the maximum all‐ owable operating temperature difference in electronic system. Hence, it is predicted that the heat pipe in present study operates with thermally good reliability even for switching the heaters.
A Mix of Dietary Fibres Changes Interorgan Nutrients Exchanges and Muscle-Adipose Energy Handling in Overfed Mini-Pigs

This study evaluates the capacity of a bread enriched with fermentable dietary fibres to modulate the metabolism and nutrients handling between tissues, gut and peripheral, in a context of overfeeding. Net fluxes of glucose, lactate, urea, short chain fatty acids (SCFA), and amino acids were recorded in control and overfed female mini-pigs supplemented or not with fibre-enriched bread. SCFA in fecal water and gene expressions, but not protein levels or metabolic fluxes, were measured in muscle, adipose tissue, and intestine. Fibre supplementation increased the potential for fatty acid oxidation and mitochondrial activity in muscle (acox, ucp2, sdha and cpt1-m, p < 0.05) as well as main regulatory transcription factors of metabolic activity such as pparα, pgc-1α and nrf2. All these features were associated with a reduced muscle fibre cross sectional area, resembling to controls (i.e., lean phenotype). SCFA may be direct inducers of these cross-talk alterations, as their feces content (+52%, p = 0.05) was increased in fibre-supplemented mini-pigs. The SCFA effects could be mediated at the gut level by an increased production of incretins (increased gcg mRNA, p < 0.05) and an up-regulation of SCFA receptors (increased gpr41 mRNA, p < 0.01). Hence, consumption of supplemented bread with fermentable fibres can be an appropriate strategy to activate muscle energy catabolism and limit the establishment of an obese phenotype.
Performance analysis of atmospheric optical PPM CDMA systems

We propose atmospheric optical code-division multiple-access (CDMA) systems. We analyze the bit-error rate of the proposed system using pulse-position modulation (PPM) with considering the effects of the scintillation, avalanche photodiode noise, thermal noise, and multi-user interference. We show that the atmospheric optical CDMA systems can realize high-speed communications when the logarithm variance of the scintillation is small. When /spl sigma//sub s//sup 2/ is large, we need to use forward-error correction codes.
Working regions of adjustable-speed units with doubly fed machines

The working regions of an adjustable-speed generation unit with a doubly fed machine connected to the power grid are determined. The analytical relations for the control range of the rotor voltage phasor due to the maximal permissible values of currents and voltages of the machine and supply cycloconverter are presented. Simulation results are shown to illustrate the operation of the system.
Role of Senescence and Aging in SARS-CoV-2 Infection and COVID-19 Disease

Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has resulted in a global pandemic associated with substantial morbidity and mortality worldwide, with particular risk for severe disease and mortality in the elderly population. SARS-CoV-2 infection is driven by a pathological hyperinflammatory response which results in a dysregulated immune response. Current advancements in aging research indicates that aging pathways have fundamental roles in dictating healthspan in addition to lifespan. Our review discusses the aging immune system and highlights that senescence and aging together, play a central role in COVID-19 pathogenesis. In our review, we primarily focus on the immune system response to SARS-CoV-2 infection, the interconnection between severe COVID-19, immunosenescence, aging, vaccination, and the emerging problem of Long-COVID. We hope to highlight the importance of identifying specific senescent endotypes (or “sendotypes”), which can used as determinants of COVID-19 severity and mortality. Indeed, identified sendotypes could be therapeutically exploited for therapeutic intervention. We highlight that senolytics, which eliminate senescent cells, can target aging-associated pathways and therefore are proving attractive as potential therapeutic options to alleviate symptoms, prevent severe infection, and reduce mortality burden in COVID-19 and thus ultimately enhance healthspan.
Application of oxygen saturation variability analysis for the detection of exacerbation in individuals with COPD: A proof‐of‐concept study

Individuals with chronic obstructive pulmonary disease (COPD) commonly experience exacerbations, which may require hospital admission. Early detection of exacerbations, and therefore early treatment, could be crucial in preventing admission and improving outcomes. Our previous research has demonstrated that the pattern analysis of peripheral oxygen saturation (SpO2) fluctuations provides novel insights into the engagement of the respiratory control system in response to physiological stress (hypoxia). Therefore, this pilot study tested the hypothesis that the pattern of SpO2 variations in overnight recordings of individuals with COPD would distinguish between stable and exacerbation phases of the disease.