Miracle-dz/UniFAR-FTUs huggingface dataset:
Using Digital Measurement–Based Care for the Treatment of Anxiety and Depression in Children and Adolescents: Observational Retrospective Analysis of Bend Health Data

Background A growing body of evidence supports the efficacy of measurement-based care (MBC) for children and adolescents experiencing mental health concerns, particularly anxiety and depression. In recent years, MBC has increasingly transitioned to web-based spaces in the form of digital mental health interventions (DMHIs), which render high-quality mental health care more accessible nationwide. Although extant research is promising, the emergence of MBC DMHIs means that much is unknown regarding their effectiveness as a treatment for anxiety and depression, particularly among children and adolescents. Objective This study uses preliminary data from children and adolescents participating in an MBC DMHI administered by Bend Health Inc, a mental health care provider that uses a collaborative care model to assess changes in anxiety and depressive symptoms during participation in the MBC DMHI. Methods Caregivers of children and adolescents participating in Bend Health Inc for anxiety or depressive symptoms reported measures of their children’s symptoms every 30 days throughout the duration of participation in Bend Health Inc. Data from 114 children (age 6-12 years) and adolescents (age 13-17 years) were used for the analyses (anxiety symptom group: n=98, depressive symptom group: n=61). Results Among children and adolescents participating in care with Bend Health Inc, 73% (72/98) exhibited improvements in anxiety symptoms and 73% (44/61) exhibited improvement in depressive symptoms, as indicated by either a decrease in symptom severity or screening out of completing the complete assessment. Among those with complete assessment data, group-level anxiety symptom T-scores exhibited a moderate decrease of 4.69 points (P=.002) from the first to the last assessment. However, members’ depressive symptom T-scores remained largely stable throughout their involvement. Conclusions As increasing numbers of young people and families seek DMHIs over traditional mental health treatments due to their accessibility and affordability, this study offers promising early evidence that youth anxiety symptoms decrease during involvement in an MBC DMHI such as Bend Health Inc. However, further analyses with enhanced longitudinal symptom measures are necessary to determine whether depressive symptoms show similar improvements among those involved in Bend Health Inc.
Immune Environment and Immunotherapy in Endometrial Carcinoma and Cervical Tumors

Simple Summary Endometrial (EC) and cervical cancers (CC) do not respond well to chemotherapy and alternative therapeutic options are lacking. Recently, EC and CC patients’ outcome were improved thanks to immunotherapy-based treatments leading to their approval in the management of these diseases. However, not all patients respond to such treatments, especially in relapsed settings. In the present review, we focused on the immunological features of both EC and CC and presented the upcoming clinical trials targeting the immune system alone or in combination that will allow to improve patient’s care. We also raise some questions that need to be solved in this field and presented the expected progresses. Abstract Endometrial cancer (EC) is the seventh most common tumor in women, and prognosis of recurrent and metastatic disease is poor. Cervical cancer (CC) represents the fifth most common gynecological cancer. While ECs are more common in developed countries, the incidence of CC has decreased due to the recent implementation of large screening and vaccination programs. Until very recently, patients with advanced or unresectable EC or CC had very limited treatment options and were receiving in first line setting platinum/taxane-based chemotherapy (CT). Significant progress in the treatment of gynecological cancers has occurred in the last few years, with the use of innovative targeted therapies and immunotherapy. However, targeting the immune system in patients with gynecological tumors remains challenging and is not always successful. In ovarian cancer, several immunotherapy treatment regimens have been investigated (as monotherapy and combination therapy in first and subsequent lines of treatment) and showed poor responses. Therefore, we specifically focused our review on EC and CC for their specific immune-related features and therapeutic results demonstrated with immunotherapy. We report recent and current immunotherapy-based clinical trials and provide a review of emerging data that are likely to impact immunotherapy development based on increased biomarkers’ identification to monitor response and overcome resistance.
Dynamics of extrasolar systems at the 5/2 resonance: application to 47 UMa

A complete study is made of the 5/2 resonant motion of two planets revolving around a star, in the model of the general planar three body problem. Families of 5/2 resonant symmetric periodic orbits are computed numerically, for the masses of the extrasolar system 47 UMa. The phase of the two planets (alignment or antialignment of perihelia and position of each planet at perihelion or aphelion) plays an important role, and the change of the phase, other things being the same, may destabilize the system. Stable motion exists even in the case where the two planetary orbits intersect. A small value of the eccentricities, for the same phase, stabilizes the system. The above results are applied to the study of 47 UMa, which according to some observations is close to the 5/2 resonance.To search for other articles by the author(s) go to: http://adsabs.harvard. edu/abstract_service. html
The impact of treatment resistance on outcome and course of electroconvulsive therapy in major depressive disorder

Major depressive disorder (MDD) is a common psychiatric disorder. Despite several treatment options, a subgroup of patients will not respond to the commonly used antidepressant treatments and thus express treatment resistance (TRD). TRD can be quantified with the Dutch Measure for Treatment Resistance in Depression (DM‐TRD). Electroconvulsive therapy (ECT) is an effective treatment for MDD, also in TRD. Yet, the position of ECT as “treatment‐of‐last‐resort” may decrease the likelihood of beneficial outcome. Our aim was to investigate the association between treatment resistance and outcome and course of ECT.
Continuity of functions operating on characteristic functions

Abstract For a locally compact abelian group G let P0(G) denote the set of all characteristic functions on G (i.e., continuous positive definite functions φ with φ(0) = 1). A complex-valued function f is said to operate on P0(G) if f(φ(·)) ∈ P0(G) whenever φ ∈ P0(G). The natural domain for functions operating on P0(G) is the set D(G) = {z ∈ C: z = φ(g), g ∈ G, φ ∈ P0(G)}. It is known that every function operating on P0(G) is continuous on the interior of D(G) for each infinite group G. On the other hand, functions discontinuous on D(G) operate on P0(G) for any discrete G. We show that, for any non-discrete group G, every function operating on P0(G) is continuous on D(G). Together with some earlier results, this statement allows us to obtain a constructive description of operating functions on the whole set D(G).
The Overexpression of Oryza sativa L. CYP85A1 Promotes Growth and Biomass Production in Transgenic Trees

Brassinosteroids (BRs) are important hormones that play crucial roles in plant growth, reproduction, and responses to abiotic and biotic stresses. CYP85A1 is a castasterone (CS) synthase that catalyzes C-6 oxidation of 6-deoxocastasterone (6-deoxoCS) to CS, after which CS is converted into brassinolide (BL) in a reaction catalyzed by CYP85A2. Here, we report the functional characteristics of rice (Oryza sativa L.) OsCYP85A1. Constitutive expression of OsCYP85A1 driven by the cauliflower mosaic virus 35S promoter increased endogenous BR levels and significantly promoted growth and biomass production in three groups of transgenic Populus tomentosa lines. The plant height and stem diameter of the transgenic poplar plants were increased by 17.6% and 33.6%, respectively, in comparison with control plants. Simultaneously, we showed that expression of OsCYP85A1 enhanced xylem formation in transgenic poplar without affecting cell wall thickness or the composition of cellulose. Our findings suggest that OsCYP85A1 represents a potential target candidate gene for engineering fast-growing trees with improved wood production.
Intrinsic defects in ZnO calculated by screened exchange and hybrid density functionals

The formation energies of intrinsic defects in ZnO are calculated by a family of screened exchange and hybrid density functionals, which include different fractions of Fock exchange and range separation in the hybrids. All functionals improve on local-density methods and agree remarkably well for formation energies of neutral vacancies but show significant variations for the energy of charge transition levels in the gap. This result highlights that a correct prediction of the band gap by a functional does not guarantee a high accuracy for the defect levels. Hybrid functionals obtain the correct localization of trapped hole states at the Zn vacancy.
Assessment of Amikacin- and Capreomycin-Related Adverse Drug Reactions in Patients with Multidrug-Resistant Tuberculosis and Exploring the Role of Genetic Factors

Following the introduction of all-oral treatment regimens for patients with drug-resistant tuberculosis (TB), second-line injectable drug applications have been reduced in the last few years. However, they are still important for anti-TB therapy. This study aims to analyze the occurrence of amikacin- and capreomycin-related adverse drug reactions (ADR) in patients with multidrug-resistant tuberculosis (MDR-TB) and evaluate the role of multiple patient-, disease-, and therapy-related factors on the frequency of the observed adverse events. In addition, the possible role of genetic risk factors was studied by full-length mitochondrial DNA sequencing. Toward this aim, we retrospectively evaluated 47 patients with MDR-TB who received amikacin and/or capreomycin. In total, 16 (34.0%) patients developed ototoxicity and 13 (27.7%) developed nephrotoxicity, including 3 (6.4%) patients who experienced both adverse events. Ototoxicity development was more common in patients who received amikacin. No other factors showed a significant impact. Nephrotoxicity was likely associated with previous renal health impairment. Full mitochondrial genome sequencing did not reveal any specific ADR-associated variants, and results showed no differences in adverse event occurrence for any specific variants, mutation count, or mitochondrial haplogroup. The absence of the previously reported ototoxicity-related mtDNA variants in our patients with ototoxicity and nephrotoxicity highlighted the complex nature of the ADR occurrence.
A bibliometric analysis of team autonomy research

Abstract Organisations all around the globe are beginning to promote autonomy rather than imposing restrictions. Thus, the use of teams with certain levels of autonomy as an organisational structure has increased in recent years to achieve corporate objectives. The article aims to review the records in the team autonomy research domain. Given the number of possibly interchangeable terms connected to the teams with certain levels of autonomy (self-managing, self-organizing, self-regulating, self-directed or semi-autonomous), a bibliometric analysis was used to obtain data from the Web of Science and Scopus databases. According to annual scientific production and coverage of the terms over time in both databases, bibliometric analysis has shown that the Scopus covers more significantly the total number of records and the time span. The most used term in both databases was “self-managing team”. Further, the article provides specific occurrences and frequencies of the terms and descriptions of the records associated with its first occurrences. This article provides the first review of records using bibliometric methods in the team autonomy research domain. It helps to describe the development of the research domain and proposes several bases for future research opportunities.
Age- and Sex-Specific Association between Lipoprotein-Related Phospholipase A2 and Cardiometabolic Risk Factors

(1) Lipoprotein-associated phospholipase A2 (Lp-PLA2) is a risk factor for predicting cardiovascular diseases. Metabolic syndrome is characterized by a state of chronic inflammation that is related to an increased risk of cardiovascular events and death. In the present study, we aimed to analyze the correlation between cardiometabolic risk factors and Lp-PLA2 levels. (2) We collected the related retrospective medical data of Chinese adults, of which 3983 were men and 2836 were women (aged ≥ 18 years), who underwent health check-ups, and discussed the sex and age-related differences. (3) Data analysis showed that Lp-PLA2 was significantly related to lipoproteins and glutamic pyruvic transaminase (GPT), and that a linear trend was observed with increasing Lp-PLA2 levels for all ages and sexes. However, fasting glucose was significantly related to Lp-PLA2 only in the younger population. The two obesity-related parameters (waist-to-height ratio and waist circumference) also had a greater correlation with Lp-PLA2 levels in the younger groups; however, the correlation weakened in the elderly population. Meanwhile, the correlation between mean arterial pressure and creatinine level and Lp-PLA2 was significant only in younger men. (4) The results show that the expression patterns of Lp-PLA2 differ between sexes and across age groups.
VIBRATION ANALYSIS OF HYPOID TRANSMISSIONS APPLYING AN EXACT GEOMETRY-BASED GEAR MESH THEORY

A new kinematic model based on exact gear geometry that is derivable from a set of manufacturing parameters is developed for analyzing the hypoid gear-mesh-coupling mechanism. The approach involves a discretization of the contact lines in the plane of action assuming an unperturbed quasi-static gear meshing state to obtain the effective mesh excitation and position vectors. This mesh formulation forms the basis for a three-dimensional multiple-degrees-of-freedom (d.o.f.s) dynamic model of the hypoid gear pair, which is used to simulate the rotation and translation response spectra due to the harmonically driven transmission error excitation. From the free and forced vibration results, the unique elastic modes that contribute to the generation of gear-mesh-induced vibrations are identified. The mesh force response function is also analyzed to examine the sensitivity of dynamic coupling and vibratory response to critical design parameters. This study demonstrates the superiority of the proposed theory compared to the simpler gear-mesh representations utilized in previous studies, and leads to the conclusion that all 6 d.o. f.s of each gear body must be modelled explicitly. Numerous parametric studies are performed to quantify the dependence of vibration modes and response trends to selected design values and operating conditions.
Atomic decompositions of function spaces with Muckenhoupt weights, and some relation to fractal analysis

This paper deals with atomic decompositions in spaces of type Bsp,q (ℝn , w), Fsp,q (ℝn , w), 0 < p < ∞, 0 < q ≤ ∞, s ∈ ℝ, where the weight function w belongs to some Muckenhoupt class Ar. In particular, we consider the weight function wΓκ (x) = dist(x, Γ)κ, where Γ is some d ‐set, 0 < d < n, and κ > –(n – d). (© 2008 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Photogrammetric Analysis of the 2013 El Reno Tornado Combined with Mobile X-Band Polarimetric Radar Data

AbstractThis study presents rapid-scanning X-band polarimetric radar data combined with photogrammetry of the El Reno tornado of 31 May 2013. The relationship between the hook echo, weak-echo hole (WEH), weak-echo column (WEC), and the rotational couplet with the visual characteristics of the tornado are shown. For the first time, cross-correlation coefficient (ρhv) and differential reflectivity (ZDR) data are included in the photogrammetric analyses. The tornado was accompanied by a large tornadic debris signature (TDS) with a diameter ~2 km wide during the analysis time. The center of the TDS was not collocated with the WEH and the rotational couplet. Instead, the TDS was displaced ~1 km to the north and within the weak-echo notch of the hook echo. A “debris overhang” was identified in vertical cross sections of the ρhv fields. The overhang was located in a weak-echo trench and a notch of high ρhv, consistent with the position of the tornado updraft. The updraft was hypothesized to be carrying small deb.
Racial differences in drug court referral, admission, and graduation rates: findings from two states and eight counties

Abstract Drug courts are often the last chance for criminal justice-involved persons with substance use disorders to avoid incarceration. Given this stark reality, participation in drug court should not be influenced by race. This study tracks cohorts of drug court referrals to compare referral, admission, and graduation rates by race in two states and eight counties in diverse regions of the United States. We compared admission and graduation rates by race in each state or county using tests of the difference between independent proportions, displayed graphically with longitudinal state-level data. Black persons had lower referral and admission rates in nearly all jurisdictions for which requisite data were available, and lower graduation rates in six of the ten jurisdictions. In statewide analyses for which adequate longitudinal data were available, racial differences in admission and graduation rates persisted for up to a decade. Practice and policy recommendations are offered to improve measurement of cultural disparities in drug courts and the broader justice system and implement remedial strategies.
Explicit approaches to modular abelian varieties

Explicit approaches to modular abelian varieties by William Arthur Stein Doctor of Philosophy in Mathematics University of California at Berkeley Professor Hendrik Lenstra, Chair I investigate the Birch and Swinnerton-Dyer conjecture, which ties together the constellation of invariants attached to an abelian variety. I attempt to verify this conjecture for certain specific modular abelian varieties of dimension greater than one. The key idea is to use Barry Mazur’s notion of visibility, coupled with explicit computations, to produce lower bounds on the Shafarevich-Tate group. I have not finished the proof of the conjecture in these examples; this would require computing explicit upper bounds on the order of this group. I next describe how to compute in spaces of modular forms of weight at least two. I give an integrated package for computing, in many cases, the following invariants of a modular abelian variety: the modular degree, the rational part of the special value of the L-function, the order of the component group at primes of multiplicative reduction, the period lattice, upper and lower bounds on the torsion subgroup, and the real volume. Taken together, these algorithms are frequently sufficient to compute the odd part of the conjectural order of the Shafarevich-Tate group of an analytic rank 0 optimal quotient of J0(N), with N square-free. I have not determined the exact structure of the component group, the order of the component group at primes whose square divides the level, or the exact order of the torsion subgroup in all cases. However, I do provide generalizations of some of the above algorithms to higher weight forms with nontrivial character. Professor Hendrik Lenstra Dissertation Committee Chair
A Study of the Response of Deep Tropical Clouds to Large-Scale Thermodynamic Forcings. Part II: Sensitivities to Microphysics, Radiation, and Surface Fluxes

Abstract The Goddard Cumulus Ensemble (GCE) model is used to examine the sensitivities of multiday 2D simulations of deep tropical convection to surface fluxes, interactive radiation, and ice microphysical processes. The simulations incorporate large-scale temperature, moisture, and momentum forcings, from the Tropical Ocean Global Atmosphere Coupled Ocean–Atmosphere Response Experiment (TOGA COARE) for the period 19–27 December 1992. This study shows that, when surface fluxes are eliminated, the mean simulated atmosphere is much cooler and drier, convection and CAPE are much weaker, precipitation is less, and low-level to midlevel cloudiness is much greater. Surface fluxes using the TOGA COARE flux algorithm are weaker than with the aerodynamic formulation, but closer to the observed fluxes. In addition, trends similar to those noted above for the case without surface fluxes are produced for the TOGA COARE flux case, albeit to a much lesser extent. The elimination of shortwave and longwave radiation is f.
STUDY OF THE PROPAGATION CHARACTERISTICS OF FLARE-ASSOCIATED INTERPLANETARY SHOCK WAVES IN THE FLARE-HELIOSPHERIC CURRENT SHEET COORDINATE SYSTEM

This paper proposes a transient source-heliospheric current sheet coordinate system, to study the solar transient disturbance propagations in the heliospheric space. Taking the flare-as an example of the transient sources, we have analysed 277 flare-associated interplanetary shock events by use of this flare-current sheet coordinate system. The main results are: 1. frequency of larger flare (Hα≥2, duration30 min.), causing the interplanetary shock and geophysical affects, presents a Gaussian distribution relative to the heliospheric current sheet, with the maximum near the heliospheric current sheet; 2. when the earth-observer and the flare are located in the same side of the heliospheric current sheet, the frequency of the flare events is obviously higher than that in the other side; 3. shock wave parameters, such as velocity V, magnetic field B, density N and temperature T, are also higher in the same side than in the other side, and the stronger shock events are mainly observed in the same side; 4. the propagation towards the heliospheric current sheet possesses certain preponderance than those towards to other directions. These results show that the presence of the heliospheric current sheet has important influence on the transient disturbances, such as flare-associsted interplanetary shock waves propagation in the heliospheric space, especially in the region from the sun to the Al-fvenic point.
Spatiotemporal instability of a variable-density Batchelor vortex

Abstract Linear and nonlinear impulse responses are computed, using three-dimensional numerical simulations, for an incompressible and variable density (inhomogeneous) Batchelor vortex at a moderately high Reynolds number, $\mathit{Re}= 667$ . In the linear framework, the computed wavepacket is decomposed into azimuthal modes whose growth rates are determined along each spatiotemporal ray, in the laboratory frame. It is found that the Batchelor vortex undergoes a convective/absolute transition when the density ratio (inner/ambient), $s$ , is varied solely (there is no need for an external counter flow to trigger this transition like that needed in the constant density case). More precisely, it is shown that the transition occurs for heavy vortices when the density ratio reaches a critical value, ${s}_{c} \simeq 1. 08$ . For light vortices ( $s\lt 1$ ) no transition was found. It is also shown that the first azimuthal mode that transits have an azimuthal wavenumber $m= \ensuremath{-} 2$ and the transition occurs for a swirl number (a measure of the azimuthal to axial velocity ratio), $q= 0. 57$ . It is followed by $m= \ensuremath{-} 1$ , then by $m= \ensuremath{-} 3$ . When nonlinearities are allowed, it is found that they saturate the amplitude within the linear-response wavepacket, leaving the wavepacket fronts unaffected. The conclusions should thus be the same as those obtained in the linear case: the linear convective/absolute transition should coincide with the nonlinear one for the variable-density Batchelor vortex.