Miracle-dz/UniFAR-FTUs huggingface dataset:
A strategy for fit-for-purpose occupant behavior modelling in building energy and comfort performance simulation

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Avaliação de um programa de acompanhamento pré-natal em meio carente

Traditional medicine and modern public health have long failed pregnant women living in poverty. With birth outcomes less than optimal, they cumulate physical and psychosocial risks that are left unattended by approaches not based on the real needs of those women. The goal of this research was to describe and assess the empowerment process within a group of pregnant women living in poverty, a group of mothers from that community, and a group of health professionals all taking part in a prenatal peer counseling program. Interviews analyzed qualitatively led to the emerging middle range theory of prenatal peer counseling. The empowerment process, including group self determination, is described with both facilitating and limiting elements. If public health intends to attack problems of social justice, we will have to revisit our partnership and integrative models in order to look into other potential models.
Survival Among Belgian Centenarians (1870-1894 Cohorts)

Poulain Michel, Chambre Dany, Foulon Michel. - Survival Among Belgian Centenarians (1870-1894 Cohorts) ; Calculating the probability of dying among post-centenarians is problematic and often flawed by a high risk of error. This is partly due to the unreliability of statistical data on centenarians, and partly to the small populations concerned. The Belgian centenarian database of over 4,000 centenarians in the 1870 ; to 1894 birth cohorts used here endeavours to compensate for these two failings. ; Using this database, we have calculated annual probabilities of dying up to 104 years of age for men and 105 for women to an acceptable degree of accuracy. Male probabilities rise from 42 to 55%, female probabilities from 35 to 50%. Expressed in days, the mean remaining female life expectancy at age 100 is an estimated 722 days, against 615 for men. At age 105, the figures are 520 and 430 days, respectively. Recent trends indicate that the hazard of death decreases consistently with, for example, a life expectancy at age 100 of 695 days for women in the 1870-1884 cohorts, and 740 days for successor generations in the 1885-1894 cohorts. The annual probability of dying ostensibly continues to increase after age 105, but the widening confidence interval due to the contracting population precludes any conclusion being drawn as to whether the probability levels off or even decreases at a particular age. Only the larger cohorts of future centenarians will offer the more reliable data needed to clarify this.
Ventrogluteal Alana İntramüsküler Enjeksiyon Uygulamasına Yönelik Hemşirelere ve Ebelere Verilen Eğitimde Nöro Linguistik Programlama Tekniğinin Etkisi

Aim: This is an experimental study to determine the effect of Neuro-Linguistic Programming techniques on nursing and midwifery training for intramuscular injection in the ventrogluteal area. (The aim of this study was to determine the effect of neuro-linguistic programming techniques on the training of nurses and midwives for intramuscular injection in the ventrogluteal area). Methods: The study was achived with nurses and midwives who are employed in Uşak Government Hospital between May 18 – September 21, 2015. In this research, sampling choice wasn’t done, nurses who didn’t get the NLP training before and agreed to participate were included in the study. Data were collected using the form which was prepared by the researchers, “Nurses and midwives Description Form”, ‘‘The Perceptions of Nurses and midwives about Intramuscular Injection Application’’ and “Ventrogluteal Area Knowledge Form’’. The data were analyzed with numbers, percentages, means, paired t test, student’s t test, chisquare test, Kruskal-Wallis, MannWhitney U and MC-Neamer tests using the SPSS 22.0 software package. Conclusion: The average (mean)age of nurses and midwives on the test group was 35.84±6.13, on the control group 39.29±7.91. On the test group, 93.3%of participants were femalesand 6.7%were males. On the control group, 100%of participants were females. The most used area for IM injections was the dorsogluteal area on the test group (95.6%) and the control group (88.9%). Knowledge point average of nurses and midwives was 14.29±8.34 on the test group before training, and after training 23.53±3.14whereas on the control group, before training 10.38±8.87, and after training 18.76±6.80. Results: The research findingsare said to be NLP technique was not effective.
3PEGFR MUTATIONS IN NON-SMALL CELL LUNG CANCER IN SOUTH AFRICA

Aim: The discovery of activating EGFR mutations sensitive to tyrosine kinase inhibitors (TKI) has changed the treatment approach in patients with non-small cell lung cancer (NSCLC) globally. There is no published data concerning EGFR mutations in NSCLC in South Africa to date. This study described factors associated with EGFR mutations, estimated mutation rate and documented mutation patterns in South African patients.
Knowledge and Attitude of Lactating Mothers towards Infant oral health care in Udaipur

Good oral health is an integral component of good health. Infant oral health (IOH) is the foundation upon which preventive education and dental care must be built to enhance the opportunity for lifetime free of preventable oral diseases. Researches show that mothers play an important role in the decision making processes regarding health care for their children. Identifying the indispensible role of mothers about health care for their children it becomes mandatory to assess the knowledge and attitudes regarding infant oral health and educating them as they are the primary care givers. A cross-sectional survey was undertaken among 400 lactating mothers post partum admitted in various government and private hospitals of Udaipur city after obtaining ethical clearance from the concerned authorities. Of the 400 subjects surveyed, included 200 rural mothers from the nearby villages of Udaipur city and 200 urban mothers from Udaipur city. The responses were assessed based on the recommendations of American of Paediatric Dentistry (AAPD). Based on the results of this study it was found that knowledge of mothers was inadequate on IOH care, urban mothers had a comparatively poorer knowledge than rural. There is a need to increase the knowledge of mothers, especially in the urban sector through effective strategies.
Role of estrogen receptor-α in pharmacogenetics of estrogen action

Purpose of review To summarize recent data regarding the role of estrogen receptor-α polymorphisms in determining the response to estrogen therapy or the risk of clinical cardiovascular events. Recent findings Recent clinical trials of hormone replacement therapy for cardiovascular disease have yielded surprisingly negative results, shifting clinical opinions from a position of presumed cardiovascular benefit to one of confirmed harm. Understanding why hormone replacement therapy has beneficial effects on intermediate risk markers for cardiovascular disease, but produces an increase in cardiovascular events, is an important public health question with the potential to elucidate fundamentally important aspects on atherogenesis, cardiovascular disease, and the biology of estrogen action. One question concerning the cardiovascular effects of hormone replacement therapy is whether genetic factors can substantially modify individual responses to estrogen treatment. New clinical trial evidence is emerging that links the presence of particular variants in the estrogen receptor to the response of HDL and other intermediate endpoints to hormone replacement therapy. Summary One or more common variants in estrogen receptor-α are associated with a differential response to hormone replacement therapy in several domains of estrogen action. However, the effect of these variants on the risk of clinical cardiovascular events in the setting of hormone replacement therapy is not yet known. Additional research focusing on the clinical impact of common variants in estrogen receptor-α, estrogen receptor-β and the progesterone receptor promise to improve clinical decision-making concerning the use of hormone replacement therapy and other novel estrogen agonists.
To study the efficacy and tolerability of fenugreek seed powder as add-on therapy with metformin in patients of type-2 diabetes mellitus -

Background: Fenugreek, an ancient herb has been known for its culinary and medicinal value in Indian Subcontinent. Its seeds, rich in fibers and phytochemical compounds, have been investigated for their hypoglycemic and multiple benefits. This study was thus undertaken to assess the anti-hyperglycemic effect of fenugreek seeds in patients of Type 2 Diabetes Mellitus (DM) as add-on therapy with metformin. Methods: An open-labelled comparative study of 12 weeks duration was conducted on patients (randomly divided in 2 groups of 30 each) of Type 2 DM. Group 1 was given metformin 500 mg twice a day while group 2 was given 500 mg of metformin along with fenugreek seed powder capsule,1 gm thrice a day. Weekly evaluation for fasting and post-prandial blood sugar was done. HbA1c estimation was done at the beginning and at the end of the study. Student’s t-test (paired and unpaired) was applied for statistical analysis. Results: After 12 weeks of treatment, there was significant fall in fasting, as well as postprandial blood sugar and HbA1c levels in group 1 and group 2. However this improvement was statistically more significant in group 2 when compared to group 1. Conclusions: This study shows the beneficial effects of fenugreek seeds on glycemic profile in patients of Type 2 DM and can be used as an add-on therapy with metformin in management of Type 2 DM.
Computational tools for designing shape- changing architectures

Smart materials or systems are characterized by having built-in sensors and actuators, adjusting their properties in response to external stimulus. The rapid development of these technologies presents an immense opportunity for designers and architects to provide innovative and creative solutions for adaptive buildings. However, there are several challenges for the incorporation of smart materials in the toolbox of architects in design practice: The lack of an overlap in knowledge between material science fields and design practices; the addition of time as a condition that renders these materials inherently dynamic; and the general disconnect between material issues in typical design settings. This paper discusses the challenges for designing shape-changing architecture and examines the way in which computational tools or digital technologies can help overcome those limitations in design practice. Finally, we discuss an approach for designing shape changing architectures with the aid of digital technologies, highlighting the different considerations that must be taken into account.
Post-Transplant Pediatric Burkitt Lymphoma

Epstein-Barr virus infections lead to a wide range of clinical entities, of which posttransplant lymphoproliferative disorder (PTLD) represents a spectrum of neoplastic lesions. Burkitt lymphoma in the setting of (BL-PTLD) is a rare but aggressive form of PTLD, with a higher Epstein-Barr virus incidence compared with sporadic and immunodeficiency-associated BL, and represents a distinct variant of monomorphic PTLD. Although some M-PTLDs can be treated less aggressively with decreased immunosuppression alone, immediate lymphoma-specific chemotherapy is required in cases of BL-PTLD because it has been associated with a more favorable outcome and it is strongly recommended in this select group of patients. The presented example illustrates this situation and serves to underscore this therapeutic approach, which is not universally practiced by all institutions dealing with these patients.
Survival of Wild Strains of Lactobacilli During Kombucha Fermentation and Their Contribution to Functional Characteristics of Beverage

Kombucha is a traditional fermented beverage originating from the northeast China (former Manchuria region) and later spread to Russia and the rest of the world. Nowadays, Kombucha has become very popular in the Western world (North America and Europe) and is often claimed to exhibit healthful properties, which include anti-microbial, anti-oxidant, anti-carcinogenic [Jayabalan et al., 2011], anti-diabetic [Hiremath et al., 2002; Aloulou et al., 2012] effects, as well as treatment for gastric ulcers [Banerjee et al., 2010] and high cholesterol [Yang et al., 2009]. It has also been shown to impact the immune response [Ram et al., 2000] and liver detoxifi cation [Lončar et al., 2000]. Kombucha is typically prepared by fermenting sweetened black tea inoculated with tea fungus pellicle or previously fermented broth (i.e. Kombucha) at a level of 100–200 mL/L. The substrate is incubated statically under aerobic conditions at 20–28°C [Sievers et al., 1995]. Duration of fermentation could differ, even up to 60 days, and in that case, the obtained
Qualitative Differences in T cell responses to Live, Attenuated and Inactivated Influenza Vaccines

Annual epidemics of influenza cause considerable morbidity and mortality. Trivalent inactivated vaccine (TIV) and live, attenuated influenza vaccine (LAIV) are licensed in the United States, and both are effective in preventing disease in persons younger than 49. Serum hemagglutination inhibition (HI) titers correlate with TIV but not LAIV efficacy, suggesting that additional effector mechanisms are induced to the live, attenuated vaccine and play an important role in protection against disease. For this reason there is a need to identify surrogate markers of LAIV efficacy that are easily measured in robust assays. We have compared the immunogenicity of TIV and LAIV in a small clinical study (16 age-matched volunteers in each vaccine group) by measuring serologic responses using traditional HI and NA inhibition assays as well as a sensitive cell-based neutralization assay. In addition, we evaluated cellular responses by measuring the quantity and quality of antigen-specific CD4+ and CD8+ T cells following vaccination. The quality of the CD4+ T cell response was different for each vaccination group, with CD4+ T cell proliferation and increased secretion of IFN-γ characteristic of responses following immunization with LAIV, while antigen-specific T cells that secreted IL-5 were more frequently measured from TIV recipients. Our results suggest that sensitive, serologic assays with broad specificity, together with CD4+ T cell proliferation and IFN-γ secretion provide a more complete measure of the immunogenicity of LAIV in adults, and could be used to enhance the identification of vaccine responders.
Addressing data complexity in imbalanced contexts

Imbalance between classes has been an important research topic in the data mining field. In the last decades, researchers have studied the impact of this problem on the learners’ performance. Also, other data difficulty factors (e.g. overlap, small disjuncts, noisy data, among others) that can be present alongside with imbalance, have been subject of research. It has been shown that they hinder the learning process and may be more problematic than class distribution. However, some questions have not been addressed yet, as the definition of metrics to evaluate the difficulty factors and the study of algorithms’ footprints, namely in contexts with different levels of classification complexity. Therefore, focusing on the overlap problem, the main goal of this thesis is to study the impact of this difficulty factor together with imbalance on the performance of data classifiers. For this, our approach consisted in three main steps: generation of synthetic data representative of different overlap contexts; identification of metrics to evaluate the presence of overlap; analysis of the performance of several machine learning algorithms using the generated sets. We propose a new metric for the degree of overlap, degOver, which gives insight into a dataset’s complexity. Furthermore, we conclude that the classification performance of some algorithms and tribes of algorithms, according to their footprint, is differently affected by a dataset’s properties and its classification complexity.
Aspectos clínicos de recém-nascidos admitidos em Unidade de Terapia Intensiva de hospital de referência da Região Norte do Brasil

Introduction: The knowledge of the characteristics of birth and newborn deaths, the biological conditions of pregnancy and delivery, as well as the neonates admitted to the Neonatal Intensive Care Unit (NICU), available through epidemiological studies can support care actions in maternal health and child, minimizing the occurrence of injuries and planning a more appropriate care. Objective: To describe the clinical aspects of newborns admitted in the reference hospital’s NICU in the northern region of the country. Methods: Cross-sectional, descriptive and documentary study with a simple random sample composed of 318 medical records of newborns admitted in the NICU in 2013, collected through structured form during the months from April to July of 2014. It was performed the simple descriptive analysis of data. Results: The sample consisted of male newborns (53.14%), premature (92.14%) and low birth weight (80.5%), with appropriate Apgar at 1st and 5th minutes and without using exogenous surfactant (54.72%). Their mothers consisted of young adults, with inadequate prenatal care (72.6%), cesarean deliveries (56.0%) without antenatal corticosteroids (91.19%) and from the interior of the state (44.0%). Prematurity was the main cause of admission to the unit (77.04%). Neonates required ventilatory support, oxygen therapy and physical therapy (92.14%). In total 55% of the deaths occurred early, being the main cause septic shock (40.83%). Conclusion: These results reveal the characteristics of newborns this unit which can contribute in directing public actions aimed at disease prevention and the promotion of maternal and newborn health at regional and national level.
REFERENCE RANGES FOR TIME DOMAIN PARAMETERS OF HEART RATE VARIABILITY IN INDIAN POPULATION AND VALIDATION IN HYPERTENSIVE SUBJECTS AND SMOKERS

Dysregulation of autonomic nervous system has been implicated in development of hypertension and cigarette smoking enhances the adrenergic activity and thus may be associated with hemodynamic changes in the cardiovascular system. In this study heart rate variability was analyzed in hypertensive subjects and smokers. Hundred healthy subjects (100), seventeen hypertensive subjects (17) and twelve smokers (12) were included in the study. Time domain parameters SDRR (standard deviation of R‐R interval), RMSSD (root mean square of successive R‐R interval) and pRR 50%were obtained from all participants after 30 minute ECG recording. All these parameters were significantly reduced in case of hypertensive subjects and smokers as compared to normal healthy population data. The base line values of time domain parameters of smokers are lower than normal population range and even all the parameters significantly reduced post smoking.
Paradoxical Response during Anti-tuberculosis Therapy

A paradoxical response in a patient infected with tuberculosis is generally defined as the clinical or radiological worsening of pre-existing tuberculous lesions or the development of new lesions in a patient who initially improves with anti-tuberculosis therapy. It occurs in about 10-15% of patients with a clinical diagnosis of Mycobacterium tuberculosis infection. Since a rapid and accurate diagnostic test is lacking, the diagnosis of this paradoxical phenomenon can only be ascertained when other differential diagnoses such as secondary infections, inadequate anti-tuberculosis therapy as a result of drug resistance, poor compliance, and adverse reactions due to therapy are excluded.
Acute Respiratory Distress Syndrome: An Autopsy Study

Aim: To find out prevalence and the associated predisposing etiologic conditions of acute respiratory distress syndrome (ARDS) amongst autopsied cases.Setting and design: The present study was a retrospective analysis of 125 cases of ARDS obtained at autopsy over a span of 4 years from 2000-2003.Materials and methods: Data was retrieved from the postmortem record of the pathology department and the medical record department. A review of histology slides was done with diffuse alveolar damage (DAD) as the correlate of ARDS at histopathology.Results: Prevalence of ARDS amongst autopsied cases was 3.15%. There were 60% cases in adult age group and of male gender; whereas 40% were children and of female gender. Almost 90% of cases succumbed to ARDS within a week of admission. The most common presenting features were of the respiratory system. The most common predisposing etiologic association was leptospirosis, septicemia and pneumonia.Conclusion: Systemic infections were the most common predisposing etiologic conditions of ARDS at autopsy.
Vitamin D Status of Healthy School Children from Western Saudi Arabia

This study was conducted to evaluate vitamin D in healthy school children from Makkah area. A total of 148 healthy school children (87 boys and 61 girls) were included in this study. Vitamin D as 25- hydroxyvitamin D (25 (OH)-D) was measured as indication of vitamin D status. Serum 25 (OH)-D less than 20 ng/ml was considered as vitamin D deficient subject. Other biochemical indicators were also measured as calcium, phosphorus, alkaline phosphatase and parathyroid hormone. The mean age of the subjects was 10.1 years. Overall serum vitamin D was 10.5 ng/ml, which was significantly higher in male group than female. About 96.7% and 78.2% of females and males were deficient in vitamin D, respectively. No sufficient vitamin D female subject was recognized. The prevalence of vitamin D deficiency in children school from Makkah was very high and the deficiency was higher in females than males. The main reason for vitamin D deficiency was the restriction to sunlight exposure.
CHALLENGES IN THE USE OF INFORMATION TECHNOLOGY IN PROCESSING HEALTH INFORMATION IN RESOURCE LIMITED SETTINGS: A COMPREHENSIVE SYSTEMATIC REVIEW

Information technology in processing and utilization of health information has significant health care outcomes. Its use in the assessment, diagnosis and management of health problems through access to relevant health information is crucial. The aim of this review was to identify the use of information technology in processing and utilization of health information in low resource settings. Method: a comprehensive systematic review focusing on resource limited settings were conducted. Results: the review identified the following challenges in the use of information technology in resource limited settings: lack of health information system and networking; limited knowledge and skills; information usersâ€™ participation; standardised health indicators and quality information processing. Conclusion: combining manual and technology assisted information processing system in less resource settings are essential in transforming and promoting the utilization of health information. The capacity development training; involvement of community professional nurses and midwives in the design and development of health information system for processing and utilization, and creating an enabling environment could overcome the challenges in the use of information technology in low resource settings.