Miracle-dz/UniFAR-FTUs huggingface dataset:
EFFECT OF EXTRACTION MEDIUM AND ACID TYPE ON THE PHYSIO -CHEMICAL PROPERTIES OF ORANGE PEELS ISOLATED PECTIN

Pectin is found to be widely used as additives in food, pharmaceutical and cosmetic industries. This study was carried out using orange peel as raw material to produce pectin and studied the effect of extraction medium type and concentrations on the Physio -chemical properties of orange peels isolated pectin and the different factors affecting pectin extraction and characterization using orange peel as raw material. Citric acid was higher in pectin yield 54.80% and 23.44% using citric and Hcl respectively. The optimum acid concentrations for pectin extraction was found to be 1 N and 0.3N for citric and Hcl respectively and the suitable time and temperature for extraction was 60 min and 90 o c for both acids used. There was a significant difference in isolated pectin physiochemical properties according to the acid used for pectin extraction. The contents of ash and a moisture in isolated pectins were lower for citric acid compared to Hcl treatment. Temperature had a significant effect on some Physio -chemical properties such as equivalent weight, methoxyl content and total anhydrouronic acid but degree of esterification wasn't significantly affected. Pectin's obtained in this study were characterized as high methoxyl pectin (HMP) since the DE was higher than 50 %. Total anhydrouronic acid for both acid was low than 65% so the pectin isolated needs more purification. In general results proved that orange citric acid prepared pectin has better physio -chemical properties which are a good indications in pectin quality evaluation.
Variability, Trend, and Extremes of the South American Vegetation‐Climate System: Results From a Coupled Regional Model

South America, especially the Amazon region, is considered a hotspot of biosphere–atmosphere interactions and presents a unique challenge for regional climate modeling. Here, we evaluate the performance of a regional model in simulating the climate–vegetation system in South America and use the model to investigate the potential role of large‐scale warming in the recently observed trend of hydroclimate and vegetation. Compared with prescribing vegetation based on observational data, adding the predictive vegetation capacity to the regional climate model enabled the model to simulate the vegetation response to climate while sustaining the model performance in reproducing the mean, variability and extremes of the regional climate. The coupled vegetation–climate model captures the recent trends in hydroclimate and vegetation productivity and their spatial contrasts, including a trend toward warmer, drier, and less productive conditions in the Amazon and Nordeste regions and a trend toward cooler, wetter, and more productive condition in the La Plata region. Results from sensitivity experiment driven by detrended boundary forcing for the regional climate suggest that much of the trends in the Amazon and Nordeste regions can be attributed to the effects of large‐scale warming, but contribution from decadal variability also plays a role especially for the most recent decade. However, the trend in the La Plata region cannot be attenuated by the removal of the boundary forcing trend, indicating the role of large‐scale circulation pattern changes. The recent trends in vegetation productivity may be early manifestation of future changes in the Amazon and surrounding regions.
Effect of Different Denture Base Materials on Normal Human Fibroblast Cell Line: An In Vitro Comparative Study

PMMA is the most commonly used denture base material, however some concerns regarding its biocompatibility have been heavily studied over the years. ACETAL and PEEK are more recently introduced denture base material alternatives which are believed to be more biocompatible than PMMA. Aim of the study: To evaluate and compare the short-term effects of PMMA, ACETAL and PEEK on human fibroblast cell line regarding cytotoxicity via direct contact. The assessment of cell cycle progression, cell death and ROS release were used as indicators. Materials and methods: WI-38 cell line was divided equally into four groups. Group I was the control group, for groups II, III and IV the WI-38 cells were cultured with PMMA, ACETAL and PEEK, respectively. The groups were all assessed by flowcytometry for cell cycle and cell death evaluation and ELISA for determining ROS after 4 days of culturing. Results: Pairwise analysis Bonferroni Method showed that highest mean values of total cell death, ROS levels and cell cycle arrest in the G2/M phase of the cell cycle was noted in group II (PMMA/WI38). Pearson’s correlation test (r test) showed that ROS levels correlated positively with total cell death and G2/M arrest. On the other hand, it correlated negatively with all the other parameters (G0/G1 and S). Conclusion: From the results of this study, we conclude that PEEK showed significantly superior biocompatibility compared to ACETAL and PMMA, enough to justify its use as a denture base material in spite of its high price.
Effect of Self Care Interventions on the Quality of Life of Older Adults with Heart Failure

Heart failure self care refers to the practices in which geriatric patients with heart failure engage in their own care to maintain their own health, and their decisions about managing signs or symptoms. Objective: The study was conducted to determine the effect of self-care interventions on quality of life (QOL) of older adults with heart failure. Setting: The study was carried out in the outpatient cardiac clinic in the health insurance hospital (Gamal Abd El Naser), Alexandria, Egypt. Subjects: The study subjects included, thirty older adults diagnosed with HF for at least 6 months. Tools: Seven measures were used in this study; the socio-demographic and clinical data structured interview questionnaire, New York Heart Association Functional Classification (NYHA), Mini-Mental State Examination (MMSE) Scale, Geriatric Depression Scale-Short Form (GDS-SF), Minnesota living with heart failure questionnaire(MLHFQ), European Heart Failure Self-Care Behavior Scale (EHFSCBS), and Dutch Heart Failure Knowledge Scale (DHFKS). Results: There are significant improvements in both quality of life and self care practice and knowledge after the implementation of the interventions which decreased gradually 6 weeks and 12 weeks later. However, they still better than before the interventions. Conclusion: Implementation of the self-care interventions proved to be effective in improving self-care knowledge, self-care practices and health related QOL for the majority of the study older adults. Recommendations: Preparation of an instructional booklet to include the self care interventions for older adults with heart failure. Further researches are needed such as: Effectiveness of nursing intervention strategies on the QOL of older adults with HF.
Decisions to Use Telemedicine During The COVID-19 Pandemic: The Effects of Perceived Fear, Information Quality, and Trust

The emergency COVID-19 pandemic brings anxiety in the world and has changed customer behavior especially in the decision to use technology in the health sector. Digital health care changing consumer behavior from using conventional health services to digital. Health technology, telemedicine are designed for long-distance communication between doctor and patient, which is considered to bring effectiveness and efficiency during the COVID-19 pandemic. This research aims to examine perceived fear, information quality, and trust to use telemedicine during the COVID-19 pandemic. This research focuses on Halodoc users aged 17-45 years and uses a non-probability technique sampling. Respondents for this research were collected using an online questionnaire. Data were analyzed by the multiple linear regression method. The result showed the information quality and trust had significant effects on the decision to use M-health. However, perceived fear has no significant effect on to use of M-health.
Singularity avoidance adaptive output‐feedback fixed‐time consensus control for multiple autonomous underwater vehicles subject to nonlinearities

This article investigates the singularity avoidance adaptive output‐feedback fixed‐time consensus control problem for multiple autonomous underwater vehicles (AUVs) subject to nonlinearities. A distributed state observer is designed to reconstruct the unmeasurable coupling states of each AUV system. In order to handle the unknown nonlinearities of the multi‐AUV systems, the fuzzy logic systems are adopted to approximate unknown hydrodynamic parameters. By combining adaptive fixed‐time control with backstepping technology, an adaptive singularity avoidance fixed‐time consensus control algorithm is developed, where a new error switching mechanism is designed for avoiding the singularity problem caused by the differentiation of the virtual control law. Subsequently, a singularity avoidance distributed adaptive output‐feedback fixed‐time fuzzy controller is presented, under which an auxiliary function is designed to handle the difficulty of the fixed‐time stability analysis under the output‐feedback control strategy, where two types of observer errors are needed in the designed Lyapunov function to achieve the fixed‐time stability. Then, based on the fixed‐time stability criterion, it is proved that both the consensus tracking performance and the closed‐loop stability can be guaranteed in fixed time. Finally, a simulation example verifies the effectiveness of the developed control strategy.
Reclaim and Valorization of Sea Buckthorn (Hippophae rhamnoides) By-Product: Antioxidant Activity and Chemical Characterization

The by-product resulting from the production of the sea-buckthorn (Hippophae rhamnoides) juice may be a functional food ingredient, being a valuable source of bioactive compounds, such as polyphenols, flavonoids, minerals, and fatty acids. For checking this hypothesis, two extracts were obtained by two different methods using 50% ethyl alcohol solvent, namely through maceration–recirculation (E-SBM) and through ultrasound extraction (E-SBUS), followed by concentration. Next, sea-buckthorn waste (SB sample), extracts (E-SBM and E-SBUS samples) and the residues obtained from the extractions (R-SBM and R-SBUS samples) were characterized for the total polyphenols, flavonoid content, antioxidant capacity, mineral contents, and fatty acids profile. The results show that polyphenols and flavonoids were extracted better by the ultrasound process than the other methods. Additionally, the antioxidant activity of the E-SBUS sample was 91% higher (expressed in Trolox equivalents) and approximately 45% higher (expressed in Fe2+ equivalents) than that of the E-SBM sample. Regarding the extraction of minerals, it was found that both concentrated extracts had almost 25% of the RDI value of K and Mg, and also that the content of Zn, Mn, and Fe is significant. Additionally, it was found that the residues (R-SBM and R-SBUS) contain important quantities of Zn, Cu, Mn, Ca, and Fe. The general conclusion is that using the ultrasound extraction method, followed by a process of concentrating the extract, a superior recovery of sea-buckthorn by-product resulting from the juice extraction can be achieved.
Development of Electronic Students’ Worksheet Linear Function-Problem Based Using Desmos Application

One effort to facilitate students in online learning and face-to-face learning during Covid-19 pandemic is the use of digital student worksheets, as an effort to practice students’ cognitive in mathematics. These research goals are to develop digital students’ worksheet of linear function-problem based using Desmos to decrease learning loss effect in students’ motivation and comprehension. And, also to know, the eligibility analysis result of worksheet that has already been made. Desmos is a web-based application, which specially created to be used in mathematics learning. It combines features of graphic calculator and classroom activities to help students study and love math. Research model in this study used ADDIE with a small group experiment using six students of SMPN 3 Surabaya as subjects. Eligibility analysis from the worksheet gains a validity score of 3.71, with very valid criteria. Practical score 3.74, with very practical criteria. And effective, since all six subjects in Study Result Test, gain higher score than the minimum score criteria of SMPN 3 Surabaya. It may take note that, it needs bigger experiments with more subjects to evaluate effective aspect further and comprehensively. This worksheet can be an alternative media for secondary students to practice linear function.
Implementation of Unified Dynamic Brand Logos of Tourism and Hotel Services as A competitive Advantage

This paper aims to investigate the impact of implementing a unified dynamic brand logos of tourism and hotels services are effectively and competitiveness with a competent brand personality. The study sample was 20 five and four stars of Luxor and Aswan hotels and 12 tourism companies. The study was conducted from August 2020 to February 2021. 130 questionnaire forms were received only 100 completed forms were valid (76.92% response rate). The study found that implementation of a unified dynamic brand logos of tourism and hotels services are effective and competitive with a competent brand personality. Finding suggested that the more the guest’s age the more guests' realization in the unified logo of the hotel & tourism services. The effect of Guests' Confidence in the Unified Logo (GCUL) is equal regardless of the nationality of the guests. The study recommends that the ministry of tourism, the tourism companies, and hotels should care about Guests’ Realization of the Unified Logo, and Unified Logo Strength has a significant influence on guests’ purchase Intention. Promoting implementation of unified dynamic brand logos of tourism and hotel services are effective and competitiveness with a competent brand personality is mandatory. Promoting implementation of unified dynamic brand logos of tourism and hotel services are effective and competitiveness with a competent brand personality is mandatory.
Confronting Yourself: Reflections on Academic Publication in Doctoral Study

Scholarly publication is a leading requirement for the Doctor of Philosophy (PhD) program. Publishing articles, therefore, has become an appealing expecta-tion for early-stage doctoral researchers (ESDRs). However, little has been done to address the dynamic relationship between the PhD and the academic publication system. Th e purpose of this study is to understand the intricately intertwined structures of PhD study and to explore the challenges related to scholarly publication. A group discussion method was deployed for data collection by recruiting international ESDRs (n=15) from three diﬀ erent countries. Primary results indi-cate that common anxiety is associated with the requirement to publish in high impact factor journals as well as the publication process. Quality supervision is recognized as inevitable to improve a mentor-mentee relationship and was found helpful in reducing the barriers to scientiﬁ c publication. Moreover, the dominant structural factors of PhD study determine the ESDRs’ decision-making. Th e study suggests that the PhD study should remain research-intensive rather than simply for the sake of obtaining a higher qualiﬁ cation.
Dysregulated Peripheral Invariant Natural Killer T Cells in Plaque Psoriasis Patients

Background: Psoriasis is a common immune-mediated skin disease that involves T-cell-mediated immunity. Invariant natural killer T (iNKT) cells are a unique lymphocyte subpopulation that share properties and express surface markers of both NK cells and T cells. Previous reports indicate that iNKT cells regulate the development of various inflammatory diseases. IL-17 is a key cytokine in the pathogenesis of psoriasis and a key therapeutic target. Secukinumab is a fully human IgG1κ antibody that targets IL-17A, thereby antagonizing the biological effects of IL-17. Objective: To explore the expression of iNKT cells in psoriasis patients and the effect of secukinumab on them. Methods: We examined the frequencies of iNKT cells, Tregs, naïve and memory CD4+and CD8+T cells in the PBMCs as well as their cytokine production in a cohort of 40 patients with moderate-to-severe plaque psoriasis and 40 gender- and age-matched healthy controls. We further collected peripheral blood of another 15 moderate-to-severe plaque psoriasis patients who were treated with secukinumab and evaluated the proportion of iNKT cells in the PBMCs at baseline and week 12. Results: The frequencies of conventional CD4+ T cells, CD8+ T cells, and Tregs in the PBMCs were comparable between psoriasis patients and healthy controls, but the frequencies of Th17 cells, Tc1 cells and Tc17 cells were increased in psoriasis patients. The frequency of peripheral iNKT cells and CD69+ iNKT cells was significantly decreased in psoriasis patients. Both iNKT2 cells and iNKT17 cells were increased in psoriasis patients, but the ratio of iNKT2 cells vs iNKT17 cells was significantly reduced in psoriasis patients. After receiving secukinumab, the proportion of iNKT cells in the PBMCs of patients was increased, while the proportion of iNKT17 cells was decreased. Conclusion: Dysregulated iNKT cells may be involved in the pathogenesis of psoriasis and secukinumab may play a regulatory role on iNKT cells.
Predictors of quality of distance education during the COVID-19 pandemic

The aim was to investigate the role of online stakeholder groups, Instructional Design and Student satisfaction in predicting Quality of distance education during the COVID-19 pandemic. A survey method was used . The online stakeholder groups, Instructional Design and Student satisfaction are the IVs, while the dependent variable is Quality of distance education. Students were selected for data collection. An online questionnaire was used to collect data from the target students. Data were collected via an online questionnaire survey. I shared with students an online link via Facebook and WhatsApp groups to reach most of the University students to fill up the online questionnaire. This study has unique implications for universities as it provides guidelines for universities to implement distance education effectively ,hoping to facilitate students learning. This research study contributes to the literature of distance education. It is a unique study in its handling of variables such as online stakeholder groups, Instructional Design and Student satisfaction as predictors of distance education during the COVID-19 pandemic. Keywords: online stakeholder groups, Instructional Design ,Student satisfaction ,Quality of distance education
Intercomparison of methods to estimate GPP based on CO2 and COS flux measurements

Abstract. Knowing the components of ecosystem scale carbon exchange is crucial in order to develop better models and future predictions of the terrestrial carbon cycle. However, there are several uncertainties and unknowns related to current photosynthesis estimates. In this study, we test the use of four different methods for quantifying photosynthesis at the ecosystem scale, of which two are based on carbon dioxide (CO2) and two on carbonyl sulfide (COS) flux measurements. The CO2-based methods use traditional flux partitioning and artificial neural networks to separate the net CO2 flux into respiration and photosynthesis. The COS-based methods make use of a unique five year COS flux data set at a boreal forest and include two different approaches to determine the leaf scale uptake ratio of COS and CO2 (LRU), of which one (LRUCAP) was developed in this study. LRUCAP was based on stomatal conductance theories, while the other was based on an empirical relation to measured radiation (LRUPAR). We found that for the measurement period 2013–2017 the artificial neural networks method gave a GPP estimate very close to that of traditional flux partitioning at all time scales. COS-based methods gave on average higher GPP estimates than the CO2-based estimates on daily (23 and 7 % higher, if using LRUPAR or LRUCAP in GPP calculation, respectively) and monthly scales (20 and 3 % higher), as well as a higher cumulative sum over three months in all years (on average 25 and 3 % higher). LRUCAP was higher than measured LRU at high radiation leading to an underestimated GPP during midday. However, in general it compared better with the CO2-based methods than LRUPAR -based GPP calculations. The applicability of LRUCAP at other measurement sites is potentially better than that of LRUPAR since its parameters are based on literature values and simple meteorological measurements, while the radiation relation in LRUPAR might be site-specific. This, however, requires further testing at other measurement sites.
A cross‐sectional natural history study of aspartylglucosaminuria

Aspartylglucosaminuria (AGU) is a rare lysosomal storage disorder that causes stagnation of development in adolescence and neurodegeneration in early adulthood. Precision therapies, including gene transfer therapy, are in development with a goal of taking advantage of the slow clinical course. Understanding of disease natural history and identification of disease‐relevant biomarkers are important steps in clinical trial readiness. We describe the clinical features of a diverse population of patients with AGU, including potential imaging and electrophysiological biomarkers. This is a single‐center, cross‐sectional study of the clinical, neuropsychological, electrophysiological, and imaging characteristics of AGU. A comprehensive assessment of eight participants (5 Non‐Finnish) revealed a mean non‐verbal IQ (NVIQ) of 70.25 ± 10.33 which decreased with age (rs = −0.85, p = 0.008). All participants demonstrated deficits in communication and gross/fine motor dysfunction. Auditory and visual evoked potentials demonstrated abnormalities in one or both modalities in 7 of 8 subjects, suggesting sensory pathway dysfunction. Brain imaging demonstrated T2 FLAIR hypointensity in the pulvinar nuclei and cerebral atrophy, as previously shown in the Finnish AGU population. Magnetic resonance spectroscopy (MRS) showed a 5.1 ppm peak corresponding to the toxic substrate (GlcNAc‐Asn), which accumulates in AGU. Our results showed there was no significant difference between Finnish and Non‐Finnish patients, and performance on standardized cognitive and motor testing was similar to prior studies. Age‐related changes on functional assessments and disease‐relevant abnormalities on surrogate biomarkers, such as MRS, could be used as outcome measures in a clinical trial.