Miracle-dz/UniFAR-FTUs huggingface dataset:
Gut Microbiota and Short Chain Fatty Acids: Implications in Glucose Homeostasis

Gut microbiota encompasses a wide variety of commensal microorganisms consisting of trillions of bacteria, fungi, and viruses. This microbial population coexists in symbiosis with the host, and related metabolites have profound effects on human health. In this respect, gut microbiota plays a pivotal role in the regulation of metabolic, endocrine, and immune functions. Bacterial metabolites include the short chain fatty acids (SCFAs) acetate (C2), propionate (C3), and butyrate (C4), which are the most abundant SCFAs in the human body and the most abundant anions in the colon. SCFAs are made from fermentation of dietary fiber and resistant starch in the gut. They modulate several metabolic pathways and are involved in obesity, insulin resistance, and type 2 diabetes. Thus, diet might influence gut microbiota composition and activity, SCFAs production, and metabolic effects. In this narrative review, we discuss the relevant research focusing on the relationship between gut microbiota, SCFAs, and glucose metabolism.
MAIN CAUSES OF EXCESS MORTALITY IN RUSSIA IN THE CONTEXT OF THE COVID-19 PANDEMIC

Significance. The COVID-19 pandemic has had a significant impact on the mortality rates in Russia. In order to objectively assess mortality, scientists propose to calculate and analyze the scale of excess mortality, which is a more comprehensive indicator of the overall impact of the pandemic on population loss compared to the number of deaths from COVID-19. The purpose of the study is to identify the scale of excess mortality in Russia in the context of the COVID-19 pandemic and its determining factors. Material and methods. The information base of the study was made up of the Rosstat demographic statistics, as well as publications in the periodical press and the Internet. Within the framework of the study, methods of statistical analysis and empirical research (comparison), general logical and analytical methods were used. Results. Using a five-year average method, the scale of excess mortality in Russia was calculated and evaluated, as well its determining factors during the pandemic were analyzed. The distribution of excess mortality by gender, age and place of residence was implemented. The factors of both direct and indirect effects of the coronavirus infection on the excess mortality rate in the country were identified. The pandemic has intensified manifestation of factors that had been determining the mortality dynamics in Russia for several years. Among the latter ones are noncommunicable diseases (primarily, cardiovascular diseases and cancer, which increase the risk of severe COVID-19, as well as those conditions that have deteriorated due to the delayed or postponed care delivery during the pandemic) and external causes of death (depression, alcohol poisoning and drug abuse).
Decline of Anti-SARS-CoV-2 IgG Antibody Levels 6 Months after Complete BNT162b2 Vaccination in Healthcare Workers to Levels Observed Following the First Vaccine Dose

Research on post-vaccination antibody dynamics has become pivotal in estimating COVID-19 vaccine efficacy. We studied anti-SARS-CoV-2 Spike RBD IgG levels in 587 healthcare workers (2038 sera) who completed BNT162b2 vaccination. Average antibody titer 3 weeks after the first dose in COVID-19-naïve participants (median 873.5 AU/mL) was 18-fold higher than the test threshold, with a significant increase 1 month (median 9927.2 AU/mL) and an exponential decrease 3 (median 2976.7 AU/mL) and 6 (median 966.0 AU/mL) months after complete vaccination. Participants with a history of COVID-19 prior to vaccination showed significantly higher antibody levels, particularly after the first dose (median 14,280.2 AU/mL), with a slight decline 1 month (median 12,700.0 AU/mL) and an exponential decline in antibody titers 3 (median 4831.0 AU/mL) and 6 (median 1465.2 AU/mL) months after vaccination. Antibody levels of COVID-19-naïve subjects after the first dose were moderately correlated with age (r = −0.4). Multivariate analysis showed a strong independent correlation between IgG levels 6 months after vaccination and both IgG titers after the first dose and 1 month after vaccination (R2 = 0.709). Regardless of pre-vaccination COVID-19 history, IgG levels 6 months after vaccination were comparable to antibody levels reached by COVID-19-naïve participants after the first vaccine dose.
Discontinuation of Long-Acting Reversible Contraceptive methods and associated factors among women in health facilities of Bahir Dar city, Northwest Ethiopia: A Cross-sectional study

Background: Long-acting reversible contraceptive discontinuation is the removal or switch to other methods before completion of duration due to any issue. Discontinuation of these methods exposes a woman to unwanted pregnancy, unsafe abortions, and unplanned births that affect millions of women worldwide. Despite the improvement in the availability and utilization of these methods, discontinuation is becoming high. There is no study conducted on discontinuation and associated factors of long-acting reversible contraceptives in Bahir Dar city, Northwest Ethiopia.Objective: This study aimed to assess the proportion and associated factors of discontinuation of Long-Acting Reversible Contraceptives among women in health facilities of Bahir Dar city, Northwest Ethiopia from April 1 to May 30/ 2021. Methods: health facility-based cross-sectional study was conducted on 415 participants from April 1 to May 30/ 2021. Data were collected through a face-to-face interview-guided questionnaire by using a systematic random sampling technique. Epi Data version 3.1 and Statistical Package for Social Sciences version 25 were used for data entry and analysis respectively. Bivariable and multivariable logistic regression analysis were employed; a P-value of less than 0.05 was considered a statistically significant factor for discontinuation Results: The overall proportion of discontinuation of long-acting reversible contraceptives was 66.3% (95% CI: 61.42-69.13). No formal education (AOR=.49; 95% CI:0.30-0.82), primary school education (AOR=.39; 95% CI:0.18-0.81), desire to be pregnant in the near future (AOR=2.57; 95% CI:1.64-4.02), no past history of modern contraceptive utilization (AOR=2.01; 95% CI:1.19-3.38), lack of counseling about benefits (AOR=1.68; 95% CI:1.08-2.62) and side effects (AOR=1.95; 95 CI:1.21-3.16) were the associated factors for discontinuation.Conclusion: The overall discontinuation of long-acting reversible contraceptives among women was low compared to Ethiopian Demographic Health Survey 2016. Education, the desire of pregnancy shortly, no history of contraceptive utilization, lack of counseling about the benefits, and side effects were factors for discontinuation. Therefore, health professionals better give counseling, implement early management of side effects and reassure clients of any concerns.
Influence of Anodizing Stages on the Preload Force of Implant–Abutment Screws and Their Benefits Regarding the Concept of Immediate Implant Placement—An In Vitro Study

The tightening torque applied to a screw in a provisional restoration immediately after implant placement in a fresh extraction socket is often too low to gain sufficient preload force. Therefore, abutment screw loosening is a common complication. The aim of this study was to investigate whether it is possible to increase the preload force of a given tightening torque by anodizing parts of the implant–abutment complex. In test group 1 (TG1), only the abutment screw was anodized, in four different stages, whereas in test group 2 (TG2), the abutment and the threaded sleeve were anodized in four anodizing stages (TG2a–TG2d). The control group (CG) consisted of non-anodized components. The results were tested for normal distribution, and the components were subsequently parametrically analyzed using a linear model. Both test groups showed higher preload forces compared to the non-anodized control group. The CG obtained an average preload force of 390 N at a tightening torque of 35 Ncm. Comparable values were already obtained at a tightening torque of 20 to 30 Ncm in TG1c/D and TG2b/d. It can be concluded that anodization of abutment screws and components is an effective measure to increase the preload force of the abutment screws by a given tightening torque.
Learning Paradox and Employee Performance: Empirical Evidence in a Vietnamese Public University

ABSTRACT The purpose of this study is to extend existing theory of organizational learning and develop a theoretical model that explores the role of exploratory learning, exploitative learning, and organizational learning capability (OLC) on individual employee performance in the higher education environment. The results of PLS-SEM analysis of data collected from 181 academics of a top public university in Ho Chi Minh City, Vietnam demonstrate that exploratory and exploitative learning are the key drivers of employee performance. Moreover, the findings shed light on the conditions that facilitate the contribution of exploratory and exploitative learning on employee performance. While balancing exploratory learning and exploitative learning in ambidextrous organizations creates synergy and fosters employee performance, the realization of this synergy requires the presence of OLC. The study also provides practical implications to assist higher education providers in public sector in understanding how learning mechanisms and OLC can work together towards enhancing academics’ performance.
Tobacco smoking was positively associated with metabolic syndrome among patients with psoriasis in Shanghai: A cross-sectional study

INTRODUCTION A number of studies have reported a high correlation between psoriasis and metabolic syndrome (MetS), and tobacco smoking is one independent risk factor accounting for the increased prevalence both for psoriasis and MetS. However, few studies have been conducted to assess the effects of tobacco smoking on co-morbidities of psoriasis and MetS. METHODS We conducted a cross-sectional study with 1014 psoriasis patients recruited from January to May 2021. Patients were recruited with a cluster survey method in Yueyang Hospital (affiliated with Shanghai University of Traditional Chinese Medicine) and Shanghai Skin Diseases Hospital (affiliated with Tongji University). Data were collected by face-to-face questionnaire interviews which included basic information, personal life habits, medical history, and clinical examinations. SPSS 24.0 was used for data analysis and a p<0.05 was considered statistically significant. RESULTS The 1014 psoriasis patients were predominantly males (65.58%), with an average age of 45.98 years (IQR: 34.00–57.00). Of these, 25.74% (261) of psoriasis had MetS and 31.85% (323) were tobacco smokers. Male psoriasis patients had higher tobacco smoking prevalence than female patients. With increasing age and BMI, the prevalence of tobacco smoking among psoriasis patients increased dramatically (p<0.01). Logistic regression indicated that psoriasis patients with tobacco smoking had 1.78 times (95% CI: 1.21–2.60) the probability to have MetS than those without tobacco smoking, even adjusting for potential confounding factors. Moreover, smoking psoriasis patients with MetS consumed more cigarettes per day, with longer smoking duration, but with an older age of smoking initiation. CONCLUSIONS The prevalence of tobacco smoking and MetS among psoriasis patients was high in Shanghai, and tobacco smoking was positively associated with the MetS among psoriasis patients. Clinicians should recommend psoriasis patients to abstain from tobacco smoking and provide tobacco cessation assistance regularly.
Periodontitis in Ischemic Stroke Patients: Case Definition Challenges of the New Classification Scheme (2018)

The identification of the associative relationships between ischemic stroke (IS) and risk factors such as advanced age and periodontitis is essential to design real screening protocols and to address them using primary and secondary preventive policies. This study primarily aimed to evaluate the diagnostic performance of the 2018 European Federation of Periodontology/American Academy of Periodontology (EFP/AAP) case definition in detecting periodontitis against the 2012 Centers for Disease Control and Prevention/American Academy of Periodontology (CDC/AAP) case definition in a group of IS patients. Secondarily, we report the periodontal status of IS patients and the associative relationship with respect to some risk factors. Patients with their first IS were assessed based on demographic data, medical, oral risk factors and periodontal parameters. The two case definitions were applied to identify the periodontitis burden. The agreement between the two case definition systems, as well as the misclassification ratio, were calculated. A total of 141 patients were included. According to the 2012 CDC/AAP and the 2018 EFP/AAP case definitions, a frequency of periodontitis of 98.5% and 97.8% based on two modalities of inclusion of cases in the severity groups, sensitivity values of 98.54% or 100%, and specificity values of 25% or 14.7% were calculated. Thus, the new case definition system has a higher capacity to detect periodontitis, especially the well-established forms.
Self-Conscious Emotions and the Right Fronto-Temporal and Right Temporal Parietal Junction

For more than two decades, research focusing on both clinical and non-clinical populations has suggested a key role for specific regions in the regulation of self-conscious emotions. It is speculated that both the expression and the interpretation of self-conscious emotions are critical in humans for action planning and response, communication, learning, parenting, and most social encounters. Empathy, Guilt, Jealousy, Shame, and Pride are all categorized as self-conscious emotions, all of which are crucial components to one’s sense of self. There has been an abundance of evidence pointing to the right Fronto-Temporal involvement in the integration of cognitive processes underlying the expression of these emotions. Numerous regions within the right hemisphere have been identified including the right temporal parietal junction (rTPJ), the orbitofrontal cortex (OFC), and the inferior parietal lobule (IPL). In this review, we aim to investigate patient cases, in addition to clinical and non-clinical studies. We also aim to highlight these specific brain regions pivotal to the right hemispheric dominance observed in the neural correlates of such self-conscious emotions and provide the potential role that self-conscious emotions play in evolution.
IL-6, IL-1RA and Resistin as Predictors of Left Ventricular Remodelling and Major Adverse Cardiac Events in Patients with Acute ST Elevation Myocardial Infarction

Despite continuous advances in diagnostic and therapeutic methods, acute myocardial infarction (AMI) remains a leading cause of morbidity and mortality worldwide. Considering the role of inflammation in AMI etiopathogenesis, we aimed to explore the role of a group of three inflammatory cytokines (IL-1RA, IL-6 and resistin) as an independent prognostic factor for LVR assessed by 3D echocardiography and MACE in patients with STEMI. We enrolled 41 patients with STEMI who underwent primary PCI. We assessed the occurrence of LVR (defined as an increase of over 20% in end-diastolic left ventricular volume at 6 months compared with baseline values) and MACE. Using the enzyme-linked immunosorbent assays (ELISA) method, we measured plasmatic levels of IL-6, IL-1RA and resistin (within 48 h after AMI and at 6 months). Out of 41 STEMI patients, 20.5% presented signs of LVR at follow up, and in 24.4%, MACE occurred. In univariate logistic regression analysis, baseline levels of IL-6 (OR = 1.042, p = 0.004), IL-1RA (OR = 1.004, p = 0.05) and resistin (OR = 1.7, p = 0.007) were all significantly associated with LVR. ROC analysis showed that the three cytokines as a group (AUC 0.946, p = 0.000) have a better predictive value for LVR than any individual cytokine. The group of cytokines also proved to have a better predictive value for MACE together than separately (AUC = 0.875, p = 0.000 for ROC regression model). IL-6, IL-1RA and resistin plasma levels at baseline have a good predictive value both as independent variables and also as a group for the development of adverse LVR and MACE at 6 months follow up after STEMI.
Detection of Surface Crevasses over Antarctic Ice Shelves Using SAR Imagery and Deep Learning Method

Crevasses are formed by glacier movement and the stresses within glacier ice. Knowledge of the crevasses’ distribution is critical for understanding the glacier and ice shelf stability. In this study, we propose an automated crevasse extraction framework based on Sentinel-1 SAR imagery and an improved U-Net network. The spatial distribution of crevasses on Antarctic ice shelves in 2020 was mapped with a spatial resolution of ~40 m, and the characteristics of crevasses on the Nickerson Ice Shelf, Jelbart Ice Shelf, Amery Ice Shelf, Thwaites Glacier, and Shackleton Ice Shelf were analyzed. The results indicated the extraction accuracy of our method was 84.2% and the F1 score was 72.5%. Compared with previous published studies, the identification of the crevasse areas had good visual consistency. However, in some scenes, the recall rate was relatively lower due to the quality of the SAR image, terrain surrounding the crevasses, and observation geometry. The crevasses on different ice shelves had different characteristics in terms of length, density, type, and spatial pattern, implying the different stress structures of ice shelves. The Thwaites Glacier and the Nickerson Ice Shelf in the West Antarctica Ice Sheet (WAIS) had shorter ice crevasses, whereas the lengths of ice crevasses on the Jelbart Ice Shelf and the Amery Ice Shelf in the East Antarctica Ice Sheet (EAIS) were relatively long. Nevertheless, there are more closely spaced crevasses on the ice shelf in WAIS compared to that in the EAIS. For the distribution of crevasse types, the Nickerson Ice Shelf and the Shackleton Ice Shelf had various forms of crevasses. There were mainly transverse crevasses developed on the Jelbart Ice Shelf and the Amery Ice Shelf. This study provides a helpful reference and guidance for automated crevasse extraction. The method proposed by this study manifests great application potential and the efficacy of producing a time-series crevasse data set with higher spatial resolution and larger coverage. In the future, more Sentinel-1 SAR imagery will be applied and the effect of temporal and spatial variations in crevasses on the stability of ice shelves will be investigated, which will contribute to project the ice shelf stability and explore the sea level rise implications of recent and future cryosphere changes.
THE FACTORS INFLUENCING COLLEGE STUDENTS’ ACCEPTANCE OF MOBILE PAYMENT IN MALAYSIA

Mobile payment refers to a payment method by which a consumer pays a bill for goods or services through a mobile terminal. mobile payment users can send payment instructions directly or indirectly to a bank financial enterprise via mobile devices or proximity sensing devices, thereby enabling currency payments and funds transfers. It realizes the integration of terminal equipment, Internet, application providers and financial institutions, and completes financial business such as currency payment. However, the adoption rates of this payment method are relatively low in Malaysia. This paper analyzes the factors that affect the willingness of Malaysian college students to use mobile payment. Three well-established theories, Unified Theory of Acceptance and Use of Technology (UTAUT), theory of Perceived Risk (PR), and Diffusion of Innovations Theory (DIT) are applied to investigate user acceptance of mobile payments. An empirical model for acceptance of mobile payment in Malaysia is established in this paper. Survey data from mobile payments users will be used to test the proposed hypothesis and the model. The result of data analysis shows that Malaysian consumers’ perceptions of cost has no statistically significant relationship with acceptance of mobile payment. On the other hand, the factor of perceived risk, personal innovativeness, performance expectancy, subjective norm and effort expectancy play important roles. JEL: M10; M15; D12 Article visualizations:
Determination of the Amino Acid Recruitment Order in Early Life by Genome-Wide Analysis of Amino Acid Usage Bias

The mechanisms shaping the amino acids recruitment pattern into the proteins in the early life history presently remains a huge mystery. In this study, we conducted genome-wide analyses of amino acids usage and genetic codons structure in 7270 species across three domains of life. The carried-out analyses evidenced ubiquitous usage bias of amino acids that were likely independent from codon usage bias. Taking advantage of codon usage bias, we performed pseudotime analysis to re-determine the chronological order of the species emergence, which inspired a new species relationship by tracing the imprint of codon usage evolution. Furthermore, the multidimensional data integration showed that the amino acids A, D, E, G, L, P, R, S, T and V might be the first recruited into the last universal common ancestry (LUCA) proteins. The data analysis also indicated that the remaining amino acids most probably were gradually incorporated into proteogenesis process in the course of two long-timescale parallel evolutionary routes: I→F→Y→C→M→W and K→N→Q→H. This study provides new insight into the origin of life, particularly in terms of the basic protein composition of early life. Our work provides crucial information that will help in a further understanding of protein structure and function in relation to their evolutionary history.
Effects of the Incorporation of Calcium Chloride on the Physical and Oxidative Stability of Filled Hydrogel Particles

In this study, the effects of calcium chloride (CaCl2) addition on the physical and oxidative stabilities of filled hydrogel were investigated. The results revealed that CaCl2 significantly enhanced the particle size, interfacial layer thickness, apparent viscosity, and viscoelastic behavior of filled hydrogels and decreased their light and whiteness values (p < 0.05). This phenomenon was mainly attributed to the strong binding ability between Ca2+ and protein/pectin mixtures, which were present in the interfacial area or aqueous phase, as verified by cryo-scanning electron microscopy results. Moreover, lower levels of CaCl2 (2 or 4 mM) significantly enhanced the oxidative stability of filled hydrogels (p < 0.05), particularly at a concentration of 4 mM. However, a higher level of CaCl2 (6 or 8 mM) resulted in an electrostatic shielding effect, which resulted in the aggregation of multiple droplets and the flocculation of the filled hydrogels, which negatively affected the oxidative stability of filled hydrogels. The findings of this study indicated that appropriate Ca2+ levels (4 mM) improved the physical and oxidative stability of filled hydrogel, and this finding may provide useful insights for the development of effective delivery systems for specific applications.