Miracle-dz/UniFAR-FTUs huggingface dataset:
The diagnostic validity of depression scales and clinical judgement in the Kurdistan region of Iraq

We aimed to find the depression rating scale with the greatest accuracy when applied by psychiatrists in Iraqi Kurdistan. We recruited 200 patients with primary depression and 200 controls living in the Kurdistan region of Iraq. The Mini International Neuropsychiatry Inventory (MINI) was used as a gold standard for DSM-IV depression. We also used: the two-item and the nine-item versions of the Patient Health Questionnaire (PHQ2, PHQ9), the Hospital Anxiety and Depression Scale (HADS), the Calgary Depression Scale for Schizophrenia (CDSS) and the Centre for Epidemiological Studies Depression (CES-D) scale. Interviews were performed by psychiatrists who also rated their clinical judgement using the Clinical Global Impression (CGI) scale and other mental health practitioners. All scales and tools performed with high accuracy and reliability. The least accurate tool was the PHQ2; however, with only two items it was efficient. Sensitivity and specificity for all tools were above 90%. Clinicians using the CGI were accurate in their clinical judgement. The CDSS appeared to be the most accurate scale for DSM-IV major depression and the PHQ2 the most efficient. However, only the CDSS appeared to offer an advantage over psychiatrists’ judgement.
PERFIL DOS CASOS NOTIFICADOS DE SÍFILIS CONGÊNITA

Este estudo analisou a incidencia de sifilis congenita, os exames para diagnostico e tratamento fornecido aos recem-nascidos. Estudo epidemiologico descritivo, do tipo levantamento retrospectivo, com abordagem quantitativa. A coleta de dados foi realizada em dezembro de 2015 no Sistema de Informacoes e Agravos de Notificacoes, fornecido pelo Departamento de Vigilância Epidemiologica e Ambiental da Secretaria Municipal de Saude de Porto Velho. A incidencia de sifilis congenita foi crescente durante o periodo estudado (2009 a 2014) de 0,92 casos para 8,65/1.000 nascidos vivos. Em relacao as gestantes, 157 (79,29%) realizaram o pre-natal, 119 (60,10%) foram diagnosticadas durante o pre-natal e 109 (55,1%) tratadas inadequadamente. Quanto aos recem-nascidos, 99 (50,00%) eram do sexo feminino, 126 (63,64%) pardas, 153 (77,27%) nasceram assintomaticas e 129 (65,15%) tratadas com penicilina G cristalina. Neste sentido, verificou-se que em Porto Velho ha desafios quanto ao diagnostico precoce e tratamento adequado das gestantes, parceiros e recem-nascidos.
Development and validation of a questionnaire measuring secondary students’ genetic essentialism and teleology (GET) conceptions

ABSTRACT In this article, we describe the main phases in the development and validation of a questionnaire measuring secondary students’ teleology and essentialism conceptions in the context of genetics. The validation process involved 714 Swiss and French secondary school students from 14 different schools. The process included interviews, several pilot studies, experts’ feedback, and lasted from January 2017 to May 2018. The final version of the test consists of 20 items based on an ordinal scale, which measure teleology and essentialism conceptions in the context of genetics. Exploratory factor analysis showed a structure with three factors and Cronbach’s alpha values indicated a good internal consistency of the items. We also report findings on students’ genetic determinism conceptions, even though the respective items were not included in the final questionnaire because their psychometric properties were not as good as those for genetic teleology and genetic essentialism. Implications for science education are discussed.
Sex-Specific Behavioural Traits of the Sirtuin-3 Knockout Mouse Model

The NAD+-dependent mitochondrial deacetylase sirtuin-3 (SIRT3) has been recognized to regulate a number of metabolic processes in peripheral tissues, however its role in the brain remains less well investigated. The results of this thesis show that sirtuin-3 displays a unique temporal and spatial pattern of mRNA and protein expression in the developing, adult, and aged brain, that encompasses both neurons and astrocytes. These data indicate sirtuin-3 is a potentially targetable product in the brain for pharmacological interventions. SIRT3 activity does influence brain function, as behavioural alterations were observed in both male and female Sirt3-KO mice. Interestingly, only female Sirt3-KO mice were found to display hyperlocomotor and exploratory behaviour in the open field, reduced anxiety-like behaviour in plus maze and light/dark paradigms, and impaired balance on the accelerated rotarod task. These observed phenotypes were also progressive across age. In addition, both male and female Sirt3-KO mice demonstrated hypersensitivity to low dose amphetamine treatment compared with wild-type animals, as increased locomotor responses and lowered anxiety responses were evident in the mutants but absent in wild-type mice. These behavioural alterations correlated with an upregulation of the mTORC1 signaling pathway in the cortex in the female Sirt3-KO mice, which could underlie the observed novelty-driven hyperactive phenotype. In summary, this thesis discloses an as-yet unrecognized role for sirtuin-3 in the regulation of behavioural activity, anxiety and motor functions that is sexdependent and influenced by both age and environment.
Addressing Suicidality: Examining Preservice School Counselors’ Perceptions of Their Training Experiences

ABSTRACT Suicidality among children and adolescents is a growing public health concern (Osterman et al., 2015). CACREP (2016) and ASCA (2012) include crisis management in their standards and competencies for school counselor education; however, minimal research exists on the nature and perceptions of this training, particularly as it pertains to managing suicide in school communities. The current study shares the results of an exploratory Consensual Qualitative Research (CQR) investigation examining how (n = 10) school counseling students made meaning of their preparatory experiences surrounding suicide prevention, assessment, and postvention. Implications for counselor educators and supervisors will be discussed.
Adding dynamicity to consumer value dimensions

The purpose of this paper is to examine the dynamic nature of consumer value by proposing a causal model that shows the existence of sequentiality in value dimensions and in their influence on satisfaction and loyalty. The paper focuses on intrinsic dimensions of value (play, aesthetics, ethics and escapism), which are fully experiential, and therefore less studied in the literature. ,The conceptual model proposed was empirically tested in tourist hotel accommodations. Data were collected through a structured questionnaire, analyzing the experiences of 285 hotel guests with structural equation modeling-partial least squares. ,The results reveal that the reactive dimensions of value (aesthetics and escapism) influence the active ones (play and ethics), which in turn affect consumers’ satisfaction and loyalty. ,This paper is exploratory and focuses on the intrinsic dimensions of value. Future research should consider the entire extrinsic/intrinsic value duality. This paper is based on a convenience sample consisting solely of hotel accommodation. Further studies based on a random sample and on other hospitality contexts would be required to generalize the results. ,This paper can help hotel managers to understand the role and importance of each intrinsic dimension of value to successfully implement their relationship marketing strategies, defined by the chain value-satisfaction-loyalty. ,This paper depicts the dynamic nature of value, with concatenated (and not simultaneous) effects of value dimensions on satisfaction and loyalty, which supports research in value co-creation.
Advance Exergo-Economic Analysis of a Waste Heat Recovery System Using ORC for a Bottoming Natural Gas Engine

This manuscript presents an advanced exergo-economic analysis of a waste heat recovery system based on the organic Rankine cycle from the exhaust gases of an internal combustion engine. Different operating conditions were established in order to find the exergy destroyed values in the components and the desegregation of them, as well as the rate of fuel exergy, product exergy, and loss exergy. The component with the highest exergy destroyed values was heat exchanger 1, which is a shell and tube equipment with the highest mean temperature difference in the thermal cycle. However, the values of the fuel cost rate (47.85 USD/GJ) and the product cost rate (197.65 USD/GJ) revealed the organic fluid pump (pump 2) as the device with the main thermo-economic opportunity of improvement, with an exergo-economic factor greater than 91%. In addition, the component with the highest investment costs was the heat exchanger 1 with a value of 2.769 USD/h, which means advanced exergo-economic analysis is a powerful method to identify the correct allocation of the irreversibility and highest cost, and the real potential for improvement is not linked to the interaction between components but to the same component being studied.
CLINICAL EVALUATION OF AN IN-OFFICE APPLICATION OF TWO COMMERCIALLY AVAILABLE DENTIFRICES ON DENTINE HYPERSENSITIVITY IN CHRONIC PERIODONTITIS PATIENTS

Aim: To evaluate the clinical effectiveness of an in-office application of desensitizing paste containing 8% arginine calcium carbonate and 5% potassium nitrate paste on dentine hypersensitivity in chronic Periodontitis patients. Materials and methods: A randomized double blind clinical trial was done in 60 chronic Periodontitis patients presenting hypersensitivity. All the patients were subjected to scaling and randomly assigned into two groups for in-office application of either 8% arginine calcium carbonate desensitizing paste (Group 1- 30 patients) or 5% potassium nitrate desensitizing paste (Group 2- 30 patients). Air blast hypersensitivity was assessed by Schiff scale at baseline, immediately post scaling and post application of desensitizing paste, 2 and 4 weeks. Clinical parameters including: full mouth plaque score (FMPS), sulcus bleeding index (SBI), clinical attachment level (CAL) and probing pocket depth (PD) were assessed at baseline and 4 weeks. The study was approved by institutional ethical committee. Data were analysed by using commercially available statistical software SPSS (P<0.05). Results: Group 1 patients showed highly significant reduction in hypersensitivity from baseline to 4 weeks when compared to Group 2 patients. Conclusion : The single in-office application of the 8% arginine calcium carbonate desensitizing paste (Colgate sensitive pro-relief®)after scaling provided significant reduction in dentine hypersensitivity when compared to 5% potassium nitrate desensitizing paste (Sensodent-k®) which sustained over a 4 week period. Keywords: Dentin hypersensitivity, Arginine-calcium carbonate, Potassium nitrate, clinical trial, desensitizing paste, Periodontitis.
Tigecycline Resistance among Clinical Isolates of Staphylococcus aureus from North-east India

Objective: The current study investigated the resistance against cycline group of antibiotic among clinical isolates of Staphylococcus aureus and molecular characterization with special reference to phenotypic screening of Tigecycline resistance. Methods: 197 coagulase producing Staphylococcus spp. were collected from private diagnostic laboratories and Silchar Medical College and Hospital, India. Phenotypic screening was done with cycline groups of antimicrobials and genotypically characterized by PCR, targeting coa gene. Detection of tetK , tetM , tetO and tetX genes was performed by PCR. Antibiogram profiling was performed and clonality was also determined. Results: 127 coagulase positive S. aureus were phenotypically screened with cycline group of antibiotics in which prominent resistant type showed highest non-susceptibility against Tigecycline 53.5% (n=68) while lowest against minocycline 20.5% (n=26). Multiplex PCR assay showed that tet(K) gene to be the most common cycline group of antimicrobial resistance determinant in S. aureus , followed by tet(M) gene. Multiple genes were also observed. However, resistant gene tet(O) was not reported. Antibiotic susceptibility testing and MIC for therapeutic purpose showed highest susceptibility rate against linezolid. DNA fingerprinting experimented with PFGE had shown seven pulsotypes. Conclusion: Resistance to cycline group of antibiotics with special reference to Tigecycline is not frequently reported from India. Thus, this study is of clinical interest in terms of selection of proper antimicrobial chemotherapy and also using Tigecycline for phenotypic screening of cycline group of antibiotic resistance in Staphylococcus aureus .
An exploration of the corporate objectives of the Rio 2016 Olympic Sponsors

The purpose of this study was to examine the corporate objectives of the “Rio 2016” Olympic Games sponsors program, expanding the literature by investigating the first Latin American edition of the Olympic Games and by introducing a multi categorical framework for understanding why sponsors invest in mega sport events. The data for this study derives from 6 in-depth interviews with highly standing managers of Rio 2016 official sponsors. All of the interviewees had a sports sponsorship background, indicating that the specific knowledge contributes positively for business reflections and decision making. This study revealed five categories of corporate objectives relevant to the Rio 2016 Olympic Games, including Corporate Social Responsibility, Branding, Organizational capability, Network, and Financial Performance. International and national companies affiliated with the Rio games had a strong interest in branding and especially in the possibility of being recognized as pioneers in Latin America in delivering the games and showing that the country can be appealing to new business and growth. The networking of the sponsors in the context of sponsor-sponsor and sponsor-sponsee was a new set of corporate objectives highlighted by this research. This indicates that events can be the beginning of a great institutional relationship between the sponsor and the sponsee. The least cited sponsors’ objective was CSR and related more with financial and branding sub-objectives. Also, the study offers evidence that sponsors may use the event as an opportunity to create a legacy after the Olympics, which can be exploited beyond the games for business benefits.
Preparing Academics to Teach: Example of a Structured Method of Preparing Doctoral Students in Business Programs to Teach

The qualifications of academics to teach students are often left unquestioned. Current accreditation standards, for an academic to teach, are typically determined by courses taken, certifications or degrees obtained, and/or industry experience. Doctoral programs are inconsistent in their approaches to formal instruction in pedagogy and their degree of emphasis on teaching skills assessment beyond the typical student teaching evaluations. Furthermore, in many instances, doctoral students begin teaching while they are still in their doctoral program without any formal training. We aim to address this institutionalized deficiency by providing a concise and actionable framework for teaching doctoral students how to teach that can serve as a template for other business school doctoral programs seeking to implement a doctoral teaching seminar. We provide an example of a doctoral teaching seminar in a College of Business developed to train doctoral students in five teaching competencies intended to ensure they are able to provide quality instruction to university students. In doing so, we explain the assignments and then provide evidence of the assignments’ effectiveness as well as the teaching seminar’s overall effectiveness.
Does Increased Body Mass Index Effect the Gains of Pulmonary Rehabilitation in Chronic Obstructive Pulmonary Disease Patients

INTRODUCTION Obesity is one of the most important public health problems, and it is increasing in prevalence worldwide (1, 2). Obesity is an inflammatory disease that involves many systems in the body, especially the respiratory system, causing changes in pulmonary functions (2). Chronic obstructive pulmonary disease (COPD) is also an important public health problem usually accompanied by nutritional abnormalities (3, 4). The majority of COPD patients are overweight or obese rather than normal or low-weight (4). Obesity and COPD cause mortality and morbidity all over the world, and this global outbreak is predicted to be much higher in the future (5). Obesity might be the reason for respiratory symptoms alone due to decreased pulmonary compliance, increased work in breathing, and increased need for oxygen, even without airway obstruction. However, obesity might also increase the numbers of obstructed peripheral airways (6). It was determined that dyspnea perception is enhanced, health status is impaired, and quality of life (QOL) is reduced in obese COPD patients compared to non-obese COPD patients (7, 8). It has been shown that pulmonary rehabilitation (PR) reduces dyspnea, enhances exercise performance, improves QOL, and decreases psychological symptoms in COPD patients (9). The present study aimed to compare the gains of PR in obese, pre-obese, and normal-weight COPD patients who completed an 8-week outpatient PR program. Original Investigation
Changing trends in the clinical and hematological profile of Plasmodium vivax mono infection

Background: Malaria continues to be a major public health problem in South East Asia. Plasmodium vivax is the most widely distributed human malaria parasite with an at-risk population of 2.5 billion persons. With the implementation of molecular diagnosis, it has become evident that P.vivax mono infection could also result in multiple organ dysfunction and severe life-threatening disease as seen in P. falciparum infection. Objectives: To study the changing trends in the clinical and hematological presentation of the Plasmodium vivax malaria and to sensitize the health care provider about the changing presentation of the Plasmodium vivax mono infection and to introduce a high index of suspicion against it’s potentially life threatening complications hitherto considered not significantly prevalent, by printing and publishing the data thus obtained and circulating it amongst the health care providers in and around Amritsar. Methods: This is a single center prospective study including 100 children attending thalassemia day care center and on regular blood transfusion therapy for a minimum of 2 years and whose ferritin level is above 1000 μgm/dl. Detailed history and examination were recorded in the proforma. Blood was drawn for thyroid function tests and most recent ferritin value obtained from patients record was used for analysis. Results: A total of 55 cases of vivax malaria were included in the study. Severe disease was present in 19(34.5%) cases of malaria. In addition to fever, the most common clinical features at presentation in children were: fatigue in 96.4%(53/55), headache in 54% (30/55), myalgia in 54%(30/55), arthralgia in 43%(24/55), vomiting in 64% (35/55) and nausea in 58%(32/55). Hepatosplenomegaly in 51% (28/55) of patients, splenomegaly in 26% (14/55) and hepatomegaly alone in 3% (2/55), varying degrees of icterus in 20% (11/55) and respiratory distress in 12.7% (7/55). Anemia was present in 89.1% (49/55) and thrombocytopenia (platelet count < 1,50,000/μL) was present in 45.5% (25/55) of the children. DOI: http://dx.doi. org/10.22192/ijcrms.2017. 03.04. 010 Int. J. Curr. Res. Med. Sci. (2017). 3(4): 63-72 64 Conclusion: In recent years, the clinical pattern of vivax malaria has changed. Severe vivax malaria is now very common with increasing mortality. Not only the number, but also the type of complication influences the outcome of complicated malaria.
Optimization of Aerobic Exercise Protocols in Diabetes Mellitus: A Randomized Trial

Abstract Background and Aims: diabetes mellitus one of the non-communicable disorders which is spreading globally irrespective of nation being developed or developing. The aim of this study was to optimize the exercise protocols and to find the efficacy of these protocols on glucose control, balance, gait and proprioception in patients suffering from type 2 diabetes mellitus. Material and Methods: 40 individuals with type 2 DM with age 35 to 60 were randomly allotted to four groups with 10 subjects in each. Cycle ergometer based aerobic exercises were given with duration of 20 or 30 minutes twice or thrice weekly for 6 weeks. Pre and post intervention was collected using Fullerton Advanced Balance scale for balance, spatiotemporal gait parameters for gait, Continuous passive motion for Proprioception and High Performance Liquid Chromatography in the laboratory. Results: data was analysed using Design Expert software. Full factorial design was used to compare role of duration and frequency of exercise on each patient. The results showed significant effect of exercises on balance, gait, proprioception and glycated haemoglobin (HbA1c). Conclusion: Aerobic exercises if given for 30 minutes and thrice weekly can show a significant improvement in complications in Diabetics.
Should cavity shave margins be performed as a routine in breast conserving surgery? A review of randomised controlled trials

Background Breast conserving surgery (BCS) is the standard of care for women with early breast cancer. The margin status is crucial in breast conserving surgery and is an important determinant for local recurrence. Local recurrence is associated with decreased overall and disease-free survival. Several studies have shown that cavity shave margin reduces the rate of positive margins and local recurrence. This review analyses the randomised controlled trials to compare the role of cavity shave margin in breast conserving surgery and its effect on positive margins and re-excision rates. Methods A systematic search of literature published before December 2016 for randomised controlled trials in MEDLINE, Pubmed, EMBASE, Proquest, Cochrane central register of controlled trials and Google scholar was peformed. Out of 12 articles 2 randomised controlled trials were eligible. Positive margins and re-excision rates were analysed using odds ratio and risk difference. Results Out of 12 studies, 2 were suitable for review. Overall positive margins were 18.3% and 36% in the CSM and No-CSM groups respectively, with an odds ratio of 0.373 (95% CI, 0.189 to 0.739, P = 0.232) and risk difference of -0.194 (95% CI, -0.336 to -0.053, P= 0.198). The re-excision rates were lower in the CSM group when compared to the No-CSM group (12.2% vs 31.3%) with an odds ratio of 0.28 (95% CI, 0.160 to 0.520, P=0.578) and risk difference was -0.199 (95% CI, -0.309 to -0.089, P=0.264). Conclusion Analysis of the randomised controlled trials showed that cavity shave margins significantly reduced the risk of positive margins and the need for re-excision. It is a beneficial technique in women undergoing lumpectomy and breast conserving surgery. Keywords: Early breast cancer, breast conserving surgery, cavity shave margins.