Miracle-dz/UniFAR-FTUs huggingface dataset:
Proteomics Analysis for Identification of Potential Cell Signaling Pathways and Protein Targets of Actions of Atractylodin and β-Eudesmol Against Cholangiocarcinoma

Objective: The study aimed to identify potential cell signaling pathways and protein targets of actions of atractylodin and β-eudesmol in cholangiocarcinoma, the two active compounds isolated from Atracylodes lancea using proteomics approach. Method: The cholangiocarcinoma cell line, CL-6, was treated with each compound for 3 and 6 hours, and the proteins from both intra- and extracellular components were extracted. LC-MS/MS was applied following the separation of the extract proteins by SDS-PAGE and digestion with trypsin. Signaling pathways and protein expression were analyzed by MASCOT and STITCH software. Results: A total of 4,323 and 4,318 proteins were identified from intra- and extracellular components, respectively. Six and 4 intracellular proteins were linked with the signaling pathways (apoptosis, cell cycle control, and PI3K-AKT) of atractylodin and β-eudesmol, respectively. Four and 3 extracellular proteins were linked with the signaling pathways (NF-κB and PI3K-AKT) of atractylodin and β-eudesmol, respectively. Conclusion: In conclusion, a total of 17 proteins associated with four cell signaling pathways that could be potential molecular targets of anticholangiocarcinoma action of atractylodin and β-eudesmol were identified through the application of proteomics approach.
THE CONTRIBUTION OF NEIGHBOURHOOD FACTORS ON THE CHOICE OF RESIDENTIAL LOCATIONS IN IBADAN CITY

This study investigates the significant contribution of neighbourhood factors on the choice of residential users’ locations in their decision making process within Ibadan North Local Government Area (IBNLGA) of Oyo State The research is a survey type in which the residential property users, and the property managers or agents within the three residential densities (high: Mokola, Oniyanrin, Omitowoju and Inalende-Ode Olo areas; medium: Basorun, Idi-Ape, Basorun, and Ashi areas; and low: Bodija Old and New Estates, Ikolaba Estate areas) of the selected neighbourhoods in IBNLGA; were administered structured and close-ended questionnaire to collect relevant data needed for analysis. The data were analysed using the binary logistic regression statistics (in which the dependent variable was choice of location and the variables of influence were ten neighbourhood factors) with the aid of Computer Aided Statistical Package for Social Science (SPSS) Version 16. The result of the analysis revealed that neighbourhood factors influencing users’ choice of residential location varied among the three residential neighbourhoods. At Pvalue 0.05 levels, the common significant factor in the choice of residential neighbourhood in all the residential densities was the rent passing. In high density neighbourhood, the most significant factor for the choice of residential location was noise level and others. In medium density areas, only distance to working place had the highest influence on users choice of location while shopping centres and availability of recreation facilities were significant factors of influence to users’ choice of location in residential low density neighbourhoodThe study recommended among others that end-users paramount needs should be incorporated into the housing and urban renewal programs / development schemes from their conception to execution in order to create a balanced and responsive
The Effects of Light on Egg Yield in Quail (Coturnix coturnix) under Laboratory Conditions

An egg has all the nutrients that people need. They have the richest proteins found in foods, contain proteins that cannot be secreted by the body and must be taken from the outside. The present study was conducted to show how aging and lighting can affect the yield and quality of egg. In thi study, six female quails under 40 groups were used to investigate the egg yield and weight of the egg that stars with the first ovulation and for a period of 12 months. Egg counts and weight of quails that were kept in separate and individual cages. Two groups were investigated for 20W florescence light and daylight conditions separately. Yearly average egg yield of 282.42 calculated as population average was distributed along days 0-124, 125-248 and 249-372 as 39.85%, 34.66%, and 25.49% respectively. The ratios of the percentage of eggs obtained between days 125-248 and 249-372 to day’s 0-124 were calculated as 92.59% and 72.53% respectively It is concluded that egg yield with an average of 282.42 eggs per quail for 12 months following the age of first ovulation was stable until month 8.
International Journal of Management Sciences and Business Research, Feb-2020 ISSN (2226-8235) Vol-9, Issue 2

Financial performance in an organization demonstrates the proficient use of resources and the capacity to generate profit. This can be done through banks maintaining high return on capital and quality assets for better performance. In Nigeria, in spite of the fact that banks are highly regulated and that return on equity requirements have been in place since 1988, many banks have failed due to insufficiency of capital and mismanagement of funds. It is thus imperative to ascertain the effect of return on equity in the financial performance of quoted deposit money banks (DMBs) in Nigeria even when cognizance is taken of both critical microeconomic factors and macroeconomic variables. This study adopted an ex-post facto research design. The target population for this research comprised 14 quoted deposit money banks in Nigeria which were in operation within the period of ten years that ranged from 2009 and 2018 from which secondary data was collected. The study employed ordinary least square regression analysis. The findings of this research revealed the result showed that capital adequacy without control variables has a positive effect on financial performance using return on equity indicating that an additional increase in capital adequacy would cause return on equity to also increase by 0.165. However, it is significant since p< 0.05. The rho value showed that 3.9 % of variations in return on equity were caused by differences in the individual specific effects while the remaining 96.1 % are variables not in the model. The f statistics value of 5.669 is highly significant at the 5% significance level which showed that the overall model is statistically significant. The study concluded that capital adequacy is a key factor affecting the financial performance using return on equity of the Nigeria deposit money banks and is essential in measuring financial performance of financial institutions. The study, therefore, recommended that the central bank of Nigeria should effectively regulate the capital and the resources owned by the deposit money banks (DMBs) in Nigeria.
Glass ionomer cement: An attractive alternative for the reconstruction of incudostapedial joint discontinuity

Background: Chronic suppurative otitis media (CSOM) is a rampant clinical entity in India, and hearing loss is a very debilitating condition which is treatable. Hence, ossiculoplasty is a frequently combined operation with myringoplasty to reconstruct the hearing apparatus of a CSOM patient. Ossiculoplasty can be accomplished through autograft, homograft, and allograft materials. The glass ionomer cement (GIC) included under bone cement is biocompatible and easily available, for restoring the ossicular continuity, more specifically, the incudostapedial joint. Objective: The purpose of this study is to evaluate hearing improvement after repair of ossicular discontinuity between the incus and stapes with GIC. Materials and Methods: This prospective clinical study was conducted in a tertiary care hospital. CSOM patients found to have incudostapedial joint discontinuity intraoperative underwent ossiculoplasty with GIC. Postoperatively, hearing was evaluated at 1 month and 3 months. Audiometric pure-tone threshold by air conduction (AC) was recorded at 0.5, 1, 2, 3, 4, 6, and 8 kHz and by bone conduction at 0.5, 1, 2, 3, and 4 kHz. As per the AAO-CHE guidelines, thresholds at 0.5, 1, 2, and 3 kHz were used to calculate the Pure Tone Average (PTA). The air-bone gap (ABG) was calculated for each patient and the results were tabulated. Results: At the end of each predesignated PTA evaluation, postoperatively, the patients showed improvement in AC thresholds and narrowing of ABG, which was statistically significant. In our study, after applying GIC, the mean AC was 30.89 dB at the end of 3rd month which was significant improvement. Eighteen patients (66.67%) had closure of ABG <20 dB. Interpretation and Conclusion: The current study reveals that tympano-ossicular reconstruction using GIC is a simple, cost-effective method which gives definite good postoperative hearing improvement. Other advantages are more physiological continuity between the incus and stapes, technically easier application, nonextrusion.
Densification and Dewatering in High Temperature Wet Pressing

A number of quantitative models of wet pressing have been proposed in the literature but none of them take into account the observed rate dependence of the structural pressure. This rate dependence, which is ascribed to the flow resistance of the water in the fibre walls, should be incorporated in wet pressing models. This paper presents a hydrodynamic model of wet pressing that includes the rate dependence of the structural pressure and thus takes into account the flow resistance of the intra-fibre water. The model is general in the sense that it can predict changes in the state of the fibre web due to a pressure pulse of arbitrary shape, under a wide range of web saturation and temperature conditions. The model can predict the effect of high press-roll temperatures. The predictive capability of the model has been studied with the help of data from the third press of a pilot paper machine. For wet pressing at ambient temperatures, the model gives good predictions of solids content over wide ranges of machine speeds, grammages and linear loads and its predictive capability is quite adequate for most engineering applications. For high press roll temperatures, the predictions are satisfactory over a wide range of press roll temperatures and linear loads but some significant systematic discrepancies occur. These predictions can probably be improved by using better estimates of the hardening curves at high temperatures. Once calibrated, the model can give considerable information about changes in the state of the web as it passes through the nip and some insights about the mechanisms that are active.
Trade and Environmental Sustainability in Africa: Do Institutions Matter?

This paper examines the impact of trade and political institutions on environmental sustainability in Africa and explores whether political institutions matter to the trade-environment relationship. We use data from a large group of African countries, covering the period 1990-2008 and two indicators of environmental sustainability: net forest depletion and CO2 emissions. The results from GMM-SYS estimates suggest that political institutions influence the relationship between trade and environmental sustainability only in the case of CO2 emissions. Interestingly, we find that polity has a U relationship with net forest depletion. In addition, the results are in favor of an environmental Kuznets curve in the case of pollution (CO2 emissions) but not in the case of net forest depletion (deforestation). We discuss the policy implications of these findings.
Ethnomedicinal survey of the plants used for gynecological disorders by the indigenous community of district Buner, Pakistan

Background: This study is the first of its own kind conducted in the study area with the aim to document and conserve the indigenous traditional knowledge of medicinal plants used for curing gynecological diseases. Materials and Methods: During the course of work, the use of medicinal plants and their ethnomedicinal uses for gynecological problems were documented by interviewing 532 people of different ages (20-110 years) through semi-structured interviews Results: The result of the present work is showing the dependency of the indigenous population on medicinal plants. In the present work 60 plants, species belonging to 40 families were collected and their medicinal uses were documented by interviewing both genders of the local population through semi-structured interviews and open-ended questionnaires. The results of the study were compared to 14 previously published articles. The result of this study indicates that Asteraceae was the dominant family with 4 species. Similarly, the dominant life form was herb (39 species) and the most used plant part was leaf (19 species). The highest RCF (Relative Citation Frequency) value was obtained for Acacia modesta Wall. 0.71. The highest UV (Use Value) was 0.91 for Trachyspermum ammi (L.) sprague and lowest UV was 0.50 for Ficus benghalensis L. The highest ICF (Informants Consensus Factor) value 1.0 was obtained for emmenagogue and vomiting and the lowest for leucorrhoea (0.67). Conclusions: The present study shows that the study area is rich in ethnomedicinal knowledge. The result also indicates that the local population is more sensitive and careful about gynecological diseases. This study is providing a baseline for future pharmacological studies to discover new herbal drugs.
PERSPECTIVES OF PARENTS ON SOCIO-EMOTIONAL CHALLENGES FACED IN EDUCATING LEARNERS WITH HEARING IMPAIRMENTS Ogada Rosemary Department of Special Education and Early Childhood Development

Every child has a right to free and compulsory education at Primary and Secondary levels. The same rights are accorded children with hearing impairments. Further, parents have a right to choose the kind of education to be given to their children. The purpose of this study was to establish the perspectives of parents on socio-emotional challenges faced in educating learners with hearing impairments in Kenya. This study adopted a qualitative research approach and a case study research design and was informed by the Social Model of Disability as propagated by Union of Physically Impaired Against Segregation (UPIAS). The target population was 177 comprising 150 parents of learners with hearing impairments, 26 teachers and 1 Quality Assurance and Standards Officer. The study employed purposive and saturated sampling techniques to select a sample size of 30 parents, 13 teachers and 1 Quality Assurance and Standards Officer. Data was collected by use of interview schedules, focus group discussion guides and document analysis guide. Trustworthiness was established by use of detailed report of the process within the study, member checks and overlapping methods. Data was analyzed using thematic analysis technique as proposed by Braun and Clarke. The study established that: most parents of learners with hearing impairments held the view that both they and their children suffered discrimination and misunderstanding on account of hearing impairment, parents and children often had conflict related to poor communication and parents could not effectively discipline their children with hearing impairments because of lack of language of communication. Recommendations of this study were that parents and the society be sensitized on the rights of learners with hearing impairment and parents be encouraged and facilitated to learn sign language. The findings of this study may be useful to educators in understanding the perspectives parents have on socio-emotional challenges of educating learners with hearing impairments and therefore put in place relevant support systems.
DEVELOPMENT OF SULFOXAFLOR FOR MANAGEMENT OF COTTON PESTS IN ASIA

Sulfoxaflor is the first member of a new chemical class of insecticides, the sulfoximines. Development of sulfoxaflor for control of sap-feeding pests in Asia began in 2007. Subsequent trials in China, Pakistan and India demonstrated excellent efficacy against key pests such as jassids, Lygus bugs, cotton aphid and whiteflies. Rates of 25-75 g ai/ha, depending on pest and geography, were very effective relative to current commercial standards used in cotton.
EATING BEHAVIORS OF UNIVERSITY STUDENTS

The nutritional intake during young adulthood supports the maintenance of physical health, impacts risk for future disease, and plays a role in the prevention of excess weight gain. According to the Food and Agricultural Organization of the United Nations (2013), Czech Republic ranks as the fattest country in Europe, based on the prevalence of obesity among adults. Around 28.7% of the adult population is considered obese, and this number is projected to rise according with the European Association for the Study of Obesity (EASO) in 2030. Currently young people’s health is receiving more attention because of alarming data regarding risk factor such obesity prevalence. Identifying people at greater risk of developing obesity is important for the development of effective public health strategies to prevent and treat excess weight gain and its associated co-morbidities. The presented study was conducted to describe food-preparation behaviors, cooking skills, resources for preparing food, and associations with diet quality among young adults from Mendel University in Brno. Finally, a number of recommendations, according to the results of this study, were formulated to foment new eating habits among the experimental sample.
Growth and Dietary Efficiency of Mulberry Silkworm (Bombyx mori L.) Under Various Nutritional and Environmental Stress Conditions

The silkworm, Bombyx mori is a poikilothermic insect and it is the main source for production of silk. Environmental factors such as temperature, humidity, light, air, feed quality as well as quantity have intimate influence on its growth and development. The consumption and utilization of food in insects facilitate the understanding of the adaptability of insects to the environment. Food consumption and utilization is influenced by various which influence the crop, the most important are the atmospheric temperature and humidity prevailing at the time of rearing (Benchamin & Jolly 1986). Humidity also plays a vital role and directly influences the physiological functions of the silkworm. With the increase of temperature (20° – 30°) The fifth instar larvae of bivoltine silkworm race (CSR2 x CSR4) were reared under various nutritional and environmental stress conditions to determine growth and dietary efficiency. The data were compared with a control, which was provided with standard feeding and reared under optimum temperature and humidity. Parameters like larval weight, silk gland weight, cocoon weight, shell weight and nutritional indices parameters like ingesta, digesta, approximate digestibility percentage and reference ratio were significantly higher in the control. Most of these parameters were significantly least in larvae reared under high temperature and low humidity. However, most of the feed conversion efficiency parameters and ingesta and digesta required to produce one gram of cocoon and shell were higher in treated batches. This may be due to physiological adaptation of the larvae under different stress conditions.
A House Full of Trap Doors. Identifying barriers to resilient drylands in the toolbox of pastoral development

Operationalising the new reversed perspective, including the need to update the methodological infrastructure to plan around drylands and pastoral development, remains a challenge. Underlying assumptions about stability and uniformity, that are a legacy of equilibrium thinking, remain embedded in the toolbox of pastoral development, starting from the technical language to talk about the subject.
eXAMininG ToURiSM STAKeHoLdeR neTWoRKS And ReLATionSHiP QUALiTY:

ReSUMo This paper draws insights from three key strategic management theories: the stakeholder theory, the network theory and the relationship quality theory. It examines how viable tourism policies could best be developed in PGNP, considering the stakeholder networks related to tourism, specifically by considering the relationship quality (trust, commitment and cooperation). Under this view it addresses the structure, nature and composition of ties among PNPG stakeholders using social network analysis (SNA) methodology, combining qualitative and quantitative techniques. Additionally, the study categorizes stakeholders according to the “stakeholder salience” model, illustrates the relationship quality among the network and stakeholder’s positioning in a complex structure of relationships informing about interactions, providing possible directions to minimize potential constraints in networks.
Human CD8 T cells are susceptible to TNF-mediated activation-induced cell death

Activation-induced cell death (AICD) is a complex immunoregulatory mechanism that causes the demise of a fraction of T-lymphocytes upon antigen-driven activation. In the present study we investigated the direct role of TNF in AICD of CD8 T lymphocytes. Methods: Human peripheral mononuclear cells were isolated from healthy donors and fresh tumor-infiltrating lymphocytes were obtained from cancer patients undergoing surgery. T cells were activated with anti-CD3/CD28 mAbs or with a pool of virus peptides, in combination with clinical-grade TNF blocking agents. Results: A portion of CD8 T cells undergoes apoptosis upon CD3/CD28 activation in a manner that is partially prevented by the clinically used anti-TNF agents infliximab and etanercept. TNF-mediated AICD was also observed upon activation of virus-specific CD8 T cells and tumor-infiltrating CD8 T lymphocytes. The mechanism of TNF-driven T cell death involves TNFR2 and production of mitochondrial oxygen free radicals which damage DNA. Conclusion: The use of TNF blocking agents reduces oxidative stress, hyperpolarization of mitochondria, and the generation of DNA damage in CD8 T celss undergoing activation. The fact that TNF mediates AICD in human tumor-reactive CD8 T cells suggests that the use of TNF-blocking agents can be exploited in immunotherapy strategies.
Kangaroo Rats

determine the average net value of the 1000-head ranch in 1982 dollars. A capitalization rate at 12% placed the ranch value at $765,015, while a capitalization rate at 10% made the ranch worth $918,020. Capitalization rates of 7 5/8% and 3°k placed the ranch value at $1.2 million and $3 million. The federal government uses the 7 5/8% capitalization rates. We feel the 7 5/8% or the 3m/a rates are the most reasonable rates," Fowler said, "because these are primarily federal land ranches. " In addition to the budgets, the report contains trends of private and state land grazing fees per head per month and gross average livestock prices per hundredweight in New Mexico between 1940 and 1982. This information and the formulas provided with each valuation technique will allow ranchers to figure their personal ranch value or set up a price scenario with their own sales records. "Much of this report is support data that has been available, but not compiled in one source," Fowler said. "It is the practical information necessary to figure ranch values in terms of 1982 dollars. " Report 15, "Alternative Valuation Methods for Cattle Ranches on the White Sands Missile Range 1942-1982," is a cooperative project involving the Range Improvement Task Force, and NMSU Agricultural Experiment Station and Cooperative Extension Service. The report is available from NMSU Agricultural Information Bulletin Office, Box 3A1, NMSU, Las Cruces, NM 88003; telephone 505/646-3228. •