Miracle-dz/UniFAR-FTUs huggingface dataset:
Medication Persistence to Lipid-lowering Agents As Cost-saving Opportunities in Indonesian Patients with Acute Coronary Syndrome after Percutaneous Coronary Intervention

Medication persistence is known to reduce acute coronary syndrome (ACS) disease mortality. As much as 13% of Indonesia's budget for national health insurance programs was used for cardiovascular disease. The number of population-based studies discussing the cost-saving opportunities of medication persistence in ACS patients undergoing percutaneous coronary intervention (PCI) is still minimal. This study aimed to investigate the estimated cost saving of persistence to lipid-lowering agents in patients with ACS after their first PCI. This hospital-based, retrospective cohort study with 2-years follow-up was conducted with 367 patients. Patients were considered having medication persistence if the gap between prescriptions was ≤30 days. Persistence assessment was done for lipid-modifying agents (WHO ATC Code: C10). The main outcome is cost-saving opportunities assessed by dividing the difference in total costs resulting from medication persistence with the difference in the proportion of major adverse cardiovascular events (MACE) and major adverse cardiovascular and cerebrovascular events (MACCE) prevented by medication persistence. The study found that direct medical costs incurred by persistent patients were significantly lower than non-persistent patients with lipid-lowering agents (IDR 9,535,209.76 versus IDR 15,933,959.28). Persistence to lipid-lowering therapy can prevent one MACE incident with cost-saving of IDR 996,192.41 when compared to non-persistence patients, while one MACCE incident can be prevented with cost-saving of IDR 733,103.02. Our study indicates that among ACS patients who underwent their first PCI, medication persistence with lipid-lowering agents can contribute to cost-saving in preventing one MACE or MACCE event.
Cancer Therapy: Preclinical Targeting the Urokinase Plasminogen Activator Receptor Inhibits Ovarian Cancer Metastasis

Purpose: To understand the functional and preclinical efficacy of targeting the urokinase plasminogen activator receptor (u-PAR) in ovarian cancer. Experimental Design: Expression of u-PAR was studied in 162 epithelial ovarian cancers, including 77 pairs of corresponding primary and metastatic tumors. The effect of an antibody against u-PAR (ATN-658) on proliferation, adhesion, invasion, apoptosis, and migration was assessed in 3 (SKOV3ip1, HeyA8, and CaOV3) ovarian cancer cell lines. The impact of the u-PAR antibody on tumor weight, number, and survival was examined in corresponding ovarian cancer xenograft models and the mechanism by which ATN-658 blocks metastasis was explored. Results: Only 8% of all ovarian tumors were negative for u-PAR expression. Treatment of SKOV3ip1, HeyA8, and CaOV3 ovarian cancer cell lines with the u-PAR antibody inhibited cell invasion, migration, and adhesion. In vivo , anti-u-PAR treatment reduced the number of tumors and tumor weight in CaOV3 and SKOV3ip1 xenografts and reduced tumor weight and increased survival in HeyA8 xenografts. Immunostaining of CaOV3 xenograft tumors and ovarian cancer cell lines showed an increase in active-caspase 3 and TUNEL staining. Treatment with u-PAR antibody inhibited a 5 -integrin and u-PAR colocalization on primary human omental extracellular matrix. Anti-u-PAR treatment also decreased the expression of urokinase, u-PAR, b 3 -integrin, and fibroblast growth factor receptor-1 both in vitro and in vivo . This study shows that an antibody against u-PAR reduces metastasis, induces apoptosis, and reduces the interaction between u-PAR and a 5 -integrin. This provides a rationale for targeting the uPAR pathway in patients with ovarian cancer and for further testing of ATN-658 in this indication. clinical evaluation.
ANTIBACTERIAL EFFECT OF FOUR IRRIGATING SOLUTIONS COMPARED TO THAT OF SODIUM HYPOCHLORITE (A COMPARATIVE IN-VITRO STUDY)

Aim : The aim of the present study was to evaluate the antimicrobial activity of four irrigating solutions against Enterococcus faecalis compared with sodium hypochlorite 5.25% namely: propolis extract, QMix, Chloroxylenol and CHX-Plus. Materials and methods : Enterococcus faecalis (batch no. 10541) thawed and incubated under aerobic condition. The harvested bacterial colonies are then spectrophotometrically calibrated to 5.9 x 104 (CFU/mL-1). Fifty specimens instrumented conventionally, reaching master apical file size #50. Twenty μL of the bacterial culture transferred to the canal lumen using sterile micropipette. All specimens were then incubated for 48 hours at 37 ˚C. Results : Intracanal sample collection by paper points showed an insignificant difference between different irrigation solutions tested and positive control Group at p=0.001. Group 1 showed a median of 8.9*10 4 (CFU/ml), where group 2, 3, 4 and positive control groups showed mean values of 2.2*10 4 , 7.3*10 4 , 8*10 4 and 3*10 4 (CFU/ml) respectively. Negative control group showed the highest significant values for colony forming units (118.4*10 4 CFU/ml). Conclusion : All groups except the saline produce of significant reduction of bacteria. Although QMix, NaOCl and chlorhexidine plus are capable of reducing bacterial count their effect is statistically insignificant.
EVALUATION OF THE EFFICACY OF PANAX GINSENG SUPPLEMENT ON NICOTINE AND CHRONIC STRESS INDUCED REPRODUCTIVE TOXICITY IN MALE ALBINO WISTAR RATS

The current study assessed the efficacy of panax ginseng supplement in nicotine and stress induced reproductive toxicity in 48 male albino Wistars rats (150-200g body weight). The rats were grouped into two sets, the first set was control, stress, nicotine and nicotine + stress induced, while the second sets were treated with panax ginseng . The result was analysed using One way ANOVA, followed by post hoc multiple comparisons and level of significance set at p<0.05. Sperm count, motility, rapid progressive forward movement and sperm viability were significantly reduced (p<0.05) in nicotine + stress compared to stress and nicotine groups. Percentage of sperm debris, non-motile sperm and slow progressive forward movement were significantly increased (p<0.05) in nicotine + stress compared to stress and nicotine groups. Luteinizing hormone and testosterone levels were significantly reduced (p<0.05) in nicotine + stress compared to stress and nicotine. Follicle stimulating hormone levels were significantly reduced (p<0.05) in stress and stress + nicotine, but significantly increased (p<0.05) in nicotine compared to control. Testicular and epididymal tissues of nicotine + stress rats were seriously impaired compared to stress and nicotine rats. Panax ginseng significantly (p<0.05) recovered the changes in the assessed sperm characteristics and hormonal parameters, and as well improved the testicular and epididymal tissue alterations observed in the untreated groups. Panax ginseng appeared to ameliorate the adverse effect induced by nicotine plus chronic stress on male reproductive parameters.
NBER WORKING PAPER SERIES HUMAN CAPITALISTS

The widespread and growing use of equity-based compensation has transformed high-skilled labor from a pure labor input to a class of “human capitalists. ” We show that high-skilled labor earns substantial income in the form of equity claims to firms’ future dividends and capital gains. Equity-based compensation has increased substantially since the 1980s, representing thirty-six percent of total compensation to high-skilled labor in US manufacturing in recent years. Ignoring equity income causes incorrect measurement of the returns to high-skilled labor, with substantial effects on macroeconomic trends. In manufacturing, the inclusion of equity-based compensation almost eliminates the decline in the high-skilled labor share, and reduces the total decline in the labor share by about one-third. Only by including equity pay does our structural estimation support complementarity between high-skilled labor and physical capital greater than that of Cobb and Douglas (1928). We also provide additional regression evidence of such complementarity. Andrea L. Eisfeldt Anderson School of Management University of California at Los Angeles 110 Westwood Plaza Suite C4.10 Los Angeles, CA 90095 and NBER andrea.eisfeldt@anderson.ucla. edu Antonio Falato Federal Reserve Board Mail Stop #89 20th Street & Constitution Ave. NW Washington, DC 20551 antonio.falato@frb.gov Mindy Z. Xiaolan University of Texas at Austin 2110 Speedway B6600 Austin, TX 78703 mindy.xiaolan@mccombs.utexas. edu A live draft link is available at https://sites.google. com/site/andrealeisfeldt/human_capitalists. pdf? attredirects=0
Managerial Activities and Global Strategy

Background: In order to continuously navigate the global environment, multinational enterprises (MNEs) make use of global strategies. The level of analysis has mostly centered around a macro-perspective of ideas and theories. However, a recent stream of research called microfoundations has served as a compliment to the macro-perspective as its’ focus lies in the individuals of the organization. Problem: Due to increasingly changing business environments, especially globally, constructing global strategies could benefit from a micro-perspective as a compliment to already existing macro-theories. More specifically, we argue that global strategy will benefit from analyzing specific microfoundations of dynamic capabilities that managers use to affect their firms’ global strategies. Purpose: In this thesis, we explore how managers use dynamic managerial capabilities to affect global strategies by answering the research question: How are managers affecting the renewal and implementation of global strategies? Method: This thesis follows a qualitative approach with semi-structured interviews. Data is mainly collected through four interviews with managers from the case company as well as global strategy documents and existing literature. Results: The findings of this study show that the dynamic managerial capabilities are all essential for the manager in order to affect the implementation and renewal of global strategies. It elaborates on a few ways in which strategy practitioners works with them to affect the strategy process. This study also finds that there is a significantly stronger emphasis on seizing and reconfiguration capabilities compared to sensing capabilities. We suggest that this unbalance may be because of changes in how technology is used in firms and ask for future research into such a claim.
The Educational Development Educational Mixed Marketing Strategies and Sustainable Competitive Advantages in Mediating The Influence of Marketing Orientation Over Marketing Performance

____________________ Abstract ___________________________________________________________________ Currently, the Private Universities (PTS) Management faced with the problems of increasing demand from its stakeholders. On the one hand the fulfillment of quality demands and quality graduates is satisfactory, on the other hand, the resources owned by the PTS is limited. In addition, PTS is also faced with the issue of competition ever increasing harsh: low input, limited resources, especially human resource, and funding. Insufficient resources lead to lower service quality. Low service satisfaction and service quality provide a negative impact on the interest to select or enter PTS. Therefore, it demands a highly credible marketing orientation. Research on the influence of marketing orientation over marketing performance turned out to have a contradiction. Therefore, this study is focused on the variable of mediating mixed marketing strategies and sustainable competitive advantage so as to close the research gap in this study that will be analyzed structurally in order to result in further research. This study was divided into two, namely descriptive and inferential path analyses, employing the SPSS 21. The results showed that in fact the level of marketing orientation, the mixed marketing strategies, and the competitive advantage were in the adequate category, while the marketing performance was experiencing decreases. The results of the path analysis are as follows. The marketing orientation variable affects directly or indirectly (through a mixed marketing strategy and a sustainable competitive advantage) over the marketing performance. The suggestion from this study is the marketing orientation needs to be trained so that optimal impact on the quality of the mixed marketing strategy creates sustainable competitive advantage and improves marketing
TCRM_A_197941 483..492

Johns Hopkins University School of Medicine, Department of Medicine, Division of Rheumatology, Baltimore, MD, USA Abstract:: Although generally well tolerated, statin users frequently report muscle-related side effects, ranging from self-limitingmyalgias to rhabdomyolysis or the rare clinical entity of statinassociated immune-mediated necrotizing myopathy (IMNM). Statin-associated IMNM is based on the development of autoantibodies against 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), the rate-limiting enzyme in cholesterol synthesis and the pharmacologic target of statins, and leads to a necrotizing myopathy requiring immunosuppressive therapy. This review attempts to recapitulate the diverse aspects of anti-HMGCR IMNM, including clinical presentation, diagnostic modalities, genetic risk associations, therapeutic options and potential pathogenetic pathways.
Discussing and Classifying eHealth Interventions

—It is often unclear why one eHealth application is successful and the other is not, because eHealth is usually approached as a black box. Evaluation is often done in the same way for treatment like and non-treatment like application, with a focus on effects and outcomes. This leads to applications being wrongfully put away, because their expected measurements did not performed as well as expected. But in reality, it may not be fair to use these measurements for these applications. Based on discussions around the terms of user and usage, as well as differences found among eHealth application when looking at the literature, two dimensions were selected. These dimensions help discussion needed to make conscious choices during the (re)design and evaluation process of eHealth applications and to opening the black box. These two continuous dimensions are: use-structure and caregiver involvement. Combining them in a grid results into the DiClas-grid. The position on the DiClas-grid inﬂuences what a ’user’ and ’usage’ means in the application, but also has implications for how to best evaluate and (re)design the application. To further help facilitating discussion, six complementing dimensions to the DiClas-grid are discussed. The DiClas-grid is a discussion and classiﬁcation tool that can help make conscious choices in (re)design and evaluation of applications.
Exosomes Derived from Pancreatic Cancer Cells Induce Osteoclast Differentiation Through the miR125a-5p/TNFRSF1B Pathway

Background: Pancreatic cancer (PC) was regarded as the 4th principal cause of cancer-related fatalities in the United States and patients usually suffered from severe nutrition deficiency, muscle wasting, as well as bone loss. In our previous research, we have found that PC-derived exosomes potentially initiate insulin resistance in skeletal muscle cells. However, the role of exosomes in the PC-related bone loss remains unknown. Methods: The effect of PC-derived exosomes on the osteoclast differentiation and femoral bone structure in the orthotopic xenograft mouse model were investigated. MiRNA expression profiles were detected and a dual luciferase experiment was conducted to identify the direct target of miRNA. Results: Our data showed that PC-derived exosomes significantly induced osteoclast differentiation and increased expression of NFAT2, TRAP, CTSK and MMP-9. The bone volume fraction and trabecular thickness of femur significantly reduced in osteoporotic model. Microarray analyses and luciferase reporter assay showed that the process was, at least partially, mediated by the miR-125a-5p/TNFRSF1B signaling pathways. Conclusion: According to the results, novel insights have been claimed the effect of exosomes derived from PC on bone deterioration and explained correlation between PC and cancer-related bone loss.
Satellite detection of volcanic BrO emissions 1

Large enhancements of the BrO total column have been detected from analysis of nadir UV-visible observations by the GOME-2 satellite instrument in the vicinity of the Kasatochi volcano (Alaska) during several days after its eruption on the 7 August 2008. The transport of the volcanic plume has been simulated using the FLEXPART dispersion model, and evidence is found that the injection altitude of the BrO plume was located between 8 and 12 km altitude, i.e., in the upper troposphere/lower stratosphere region. Based on these results, the total mass of reactive bromine emitted by the volcano is estimated to be in the range from 50 to 120 tons.
the Lupus-Prone NZM2410 Mouse Model Preferentially Outside of Germinal Centers in Cells Is Antigen Dependent and Occurs Specific B - Activation of Rheumatoid Factor

AM14 rheumatoid factor (RF) B cells in the MRL /lpr mice are activated by dual BCR and TLR7/9 ligation and differentiate into plasmablasts via an extrafollicular (EF) route. It was not known whether this mechanism of activation of RF B cells applied to other lupus-prone mouse models. We investigated the mechanisms by which RF B cells break tolerance in the NZM2410-derived B6. (TC) strain in comparison with C57BL/6 (B6) controls, each expressing the AM14 H chain transgene in the presence or absence of the IgG2a a autoantigen. The TC, but not B6, genetic background promotes the differentiation of RF B cells into Ab-forming cells (AFCs) in the presence of the autoantigen. Activated RF B cells preferentially differentiated into plasmablasts in EF zones. Contrary to the MRL/ lpr strain, TC RF B cells were also located within germinal centers, but only the formation of EF foci was positively correlated with the production of RF AFCs. Immunization of young TC.AM14 H chain transgenic mice with IgG2a a anti-chromatin immune complexes (ICs) activated RF B cells in a BCR- and TLR9-dependent manner. However, these IC immunizations did not result in the production of RF AFCs. These results show that RF B cells break tolerance with the same general mechanisms in the TC and the MRL/ lpr lupus-prone genetic backgrounds, namely the dual activation of the BCR and TLR9 pathways. There are also distinct differences, such as the presence of RF B cells in GCs and the requirement of chronic IgG2a a anti-chromatin ICs
Effects of team diversity on project performance in construction projects

Purpose The purpose of this paper is fourfold: first, to investigate the effect of team diversity on different types of conflicts; second, to determine if team diversity is significantly correlated with project performance; third, to investigate the mediating effect of project conflicts on the relationship between team diversity and project performance and fourth, to examine the relationship between different types of conflicts and project performance in construction projects. Design/methodology/approach A theoretical model was developed and a questionnaire survey was conducted with 246 professionals. The structural equation modeling technique was applied to analyze the data. Findings The results showed that: team diversity was positively associated with project performance; the introduction of conflicts significantly weakened the effect of diversity on performance; conflicts have both constructive and destructive effects on project performance; and team diversity affected project performance through the mediating effects of task conflict and relationship conflict, thus adding both positive and negative effects on performance. Research limitations/implications There are other factors which may affect conflicts and project performance such as communication, trust and contract. Future research could be conducted to determine the role of these variables in determining the effects of team diversity on performance. Practical implications It is necessary to reduce the relationship conflict whereas maintaining a “healthy” level of task conflict. In light of this, the conclusions of this study highlight practical implications as follows: project teams should attach importance to diverse partner selection and select cooperative partners whose value orientations are similar; when implementing a construction project, the structure of diverse project teams should keep relatively stable, avoiding too many teams entering or exiting the project in a short period; project teams should make greater efforts to deal with destructive conflicts via relational governance such as trust and communication. Originality/value This study contributes to the literature in three areas. First, this study investigated the dynamic mechanism between team diversity, conflicts and performance in construction projects. Second, this study contributes to the body of knowledge on validating the mediating effects of conflicts on the relationship between team diversity and performance. Third, this study validated the positive and negative effects of team diversity on performance with different types of conflicts as mediation variables in construction projects.
Detailed Analysis of the CD8 (cid:1) T-Cell Response following Adenovirus Vaccination

We examined CD8 (cid:1) T-cell expansion and function following intramuscular immunization with a recombi-nant adenovirus. This study has identiﬁed a number of properties which may explain the strong immunoge- nicity of adenovirus vectors: (i) the ability to deliver large amounts of antigen into the lymphoid tissues, (ii) the ability to induce rapid expansion and migration of CD8 (cid:1) T cells throughout the lymphatics, and (iii) the ability to produce a sustained, high-level CD8 (cid:1) T-cell response. Adenovirus (Ad) vectors have proven to be highly efﬁcacious vaccine carriers in both murine and primate models (2, 8, 17–20). Although the ability of Ad vectors to elicit antigen-speciﬁc CD8 (cid:1) and CD4 (cid:1) T cells is well described, little is known about the kinetics or nature of the immune response following Ad immunization (12, 21, 22). The aim of the present study was to examine the kinetics of the antitransgene CD8 (cid:1) T-cell response following Ad immunization and characterize the relationship between CD8 (cid:1) T-cell activation and transgene expression. To this end, mice were immunized with an Ad expressing a model antigen, termed SIINFEKL-Luc, where the SIINFEKL epitope