Miracle-dz/UniFAR-FTUs huggingface dataset:
SAT0553 Detection of serum level changes of matrix metalloprotienase-13 and inter leukin-1 beta during remission and flare-ups of primary osteoarthritis of the knees

Background The diagnosis of osteoarthritis is currently based on radiographic criteria (eg, joint space width) and clinical symptoms (eg, pain and loss of function). The evaluation of new disease-modifying osteoarthritis drugs (DMOADs) is performed on the same basis, since the regulatory bodies currently require evidence for an impact on radiographic joint space narrowing (JSN) and an impact on symptoms However, the limitations of radiography have led to research into alternative parameters for monitoring osteoarthritis that could serve as biomarkers in drug development. Objectives Detection the serum level of MMP-13 and IL-1 β In OA of the knee during remission and exacerbation and if these Biomarkers can be validated as gold biomarkers in assessing OA progression and drug development in OA treatment. Methods This study was performed on 60 patients with knee osteoarthritis, 18 males (30%) and 42 females (70%), all diagnosed as osteoarthritis of one or both knees. Their ages ranged from (40 -65) years. The duration of their disease ranged from one to 15years. The control groups were 8 males (32%) and 17 females (68%). their ages ranged from (40–65) years. The patients were allowed to continue on the medications that they have pro inflammatory cytokines (IL-1β) and degradative enzymes (MMP-13) are measured. Clinical assessing for pain using visual analogue scale (0–10) Assessing for pain, stiffness and physical functions by: (A) the WOMAC osteoarthritis index (B) Lequesne's algo functional index Asssesing the flare-ups using Knee Osteoarthritis Flare Ups Score (KOFUS). Results Patients who had 3 flare-ups (during one year follow up) showed the statistically significantly highest mean IL-1β & MMP13 level. There was no statistically significant difference between patients with no flare-up, 1 flare-up and 2 flare-ups; all showed statistically significantly lower mean levels. There was a statistically significant positive (direct) correlation between IL-1β, disease duration, KL, VAS, stiffness score, pain score, functional score, WOMAC and KOFUS. An increase in all these variables is associated with an increase in IL-1β & MMP13. Conclusions There is a potential role for IL1 beta and MMP 13 biomarkers in assessing the development in osteoarthritis. IL 1 β and MMP 13 were founded to be correlated positively in patients with knee OA this correlation sounded right as the expression of MMP 13 depends on the level of IL1 β. Although all medications groups failed to lower the level of IL 1 β and MMP 13,yet there was a numerical difference in favor of Diacerine and NSAID. patients on both Diacerine and NSAID had the lowerest rate of flare ups It is recommended that the early measurement of biomarkers may detect cases to progress and thus stronger treatment may be given for these groups. Disclosure of Interest None declared
Assessments of Predominance of Cardiac Autonomic Neuropathy in Iraqi Diabetic Subjects

INTRODUCTION: Autonomic neuropathy is an important cause of diabetic morbidity, and is related to the age of subject and duration of disease (1) ,also it was strongly associated with retinopathy (2) . Diabetic autonomic neuropathy can develop in subjects with type 1 or type 2 diabetes. Although autonomic neuropathy may occur at any stage of diabetes (3,4) usually it develops in subjects who have had the disease for 20 years or more with poor glycemic control. In autonomic disease, the
Impact of having leg amputation on sexual health: a systematic review

Amputation is a life-changing event that leads to depression along with the challenges it brings. It affects the lives of individuals in terms of various limitations in professional performances; social, entertaining and sexual activities. But, in all societies, the sexuality of individuals with disabilities is being ignored and almost never mentioned in this field. The aim of this study is to examine the sexual health problems and the difficulties in sexual life of the individuals who comes to the disabled state after the amputation.For the study, 13 data bases were scanned in totaly. Scanning was done in English and Turkish languages by use of MeSH terms; ''leg/limb amputation'' (or amputation) and ''sexual life'' (or sexual health, sexuality, sexual behaviour, sexual disfunction). The publications reached as a result of the scanned databases were evaluated according to the inclusion criteria. As a result of the screening, five studies were included in the study.As a result of the studies, it has been found that the individuals who have amputation experience sexual problems and the amputation affects the sexual health. In rehabilitation practice that are consulted after amputation, it is mentioned that sexuality is not a primary issue, but it is highly signıficant and it should be emphasized more. It, also, not considered enough by health professionals who provide rehabilitation services, and they stated that this issue should be discussed with great importance by health professionals.The fact that studies on limb amputation are very few and there is no existence of any work done in Turkey on this subject shows the necessity of giving more importance to the subject. Studies have shown that health professionals do not provide for counseling on sexuality, they do not have sufficient knowledge and skills in this area, and the patients’ needs are not supplied enough.
Effect of sputum bacteriology on the prognosis of patients with acute exacerbations of bronchiectasis

Aim: We aimed to determine the effect of infection on the prognosis in patients who were hospitalized for bronchiectasis exacerbation. Methods: Sputum cultures of 38 patients diagnosed with bronchiectasis exacerbation were collected at the time of ICU admission. Clinical characteristics, LTOT, ABG analysis, the type and radiological extent of disease, PAP, GCS, and APACHE II score were recorded. Results of sputum cultures, IMV need, mortality, and duration of ICU stay were also recorded. Results: The mean age of study group was 65.18 ±17.04. The etiology of bronchiectasis was idiopathic in 15, tuberculosis in 12, reccurrent pneumonia in 10, and immune deficiency in 1 patient. Bronchiectasis types were cystic in 21, varicose 9 and cylindirical 8 patients. Eight patients had bronchiectasis in 1-5, 10 patients had 6-9, and 20 patients had >9 bronchopulmonary segments at HRCT. The bacteriological analysis of sputum revealed P. aeroginosa in 14, S. pneumonia in 3, H. influenza in 1, E.coli in 2, and acinetobacter in 1 patient. 17 patients needed IMV during ICU follow up, of whom 13 died. Bacterial proliferation in sputum culture was correlated to IMV treatment need. The radiological disease extent was greater in patients with culture proliferation. The patients who did not need IMV treatment had a lower radiological disease extent, PAP, CRP, and number of hospital admissions. A multiple regression analysis for survival involving the variables of PAP, culture results, and radiological disease extent revealed that bacterial proliferation was the most important factor for treatment success (OR:2.05, CI:0.875-3.230;p=0.04). Conclusion: Positive bacterial examination of the sputum is the most important prognostic factor for patients with bronchiectasis exacerbation admitted to ICU.
Static Recrystallization Mechanism of LZ50 Steel and Cellular Automata Simulation

： Although LZ50 steel is a classic axle steel, there are many deficiencies in the research of microstructure evolution in the forging process. In order to investigate the influence of process parameters on the evolution of microstructure, the static recrystallization behavior of LZ50 steel is analyzed by double-pass hot compression test on Gleeble-3500 thermal simulation machine. It is found that the static recrystallization volume fraction is higher at high temperature, high strain and high strain rate. Temperature and strain have a great influence on the static recrystallization volume fraction. The static recrystallization kinetics model isconstructed according to the stress-strain curve. The simulation results of cellular automata are consistent with the experimental results, which can predict the static recrystallization behavior of LZ50 steel. It can be seen from the simulation that the higher temperature is, the faster new grain growth rate will be, however, the higher strain or strain rateis, the faster the nucleation will be.The electron backscatter diffraction (EBSD) technique is used to analyze the microstructure orientation of LZ50 steel after deformation. The nuclei of static recrystallization forms by bulging of initial grain boundaries. There is a difference in dislocation density onboth sides of original grain boundary. The grain boundary will migrate to the side with high dislocation density to promote the generation of new nuclei. The obtained evolution law of the organization has guiding significance for production and processing.
Effect of Administration of Crystalloid IV Fluids Preoperatively on Postoperative Pain

Pain is a sensory and emotional experience that is influenced by physiologic, sensory, affective, cognitive, socio-cultural and behavioral factors. Postoperative pain is the commonest reason for delayed discharge and unanticipated hospital admission after ambulatory surgery. Our Objective is to test the hypothesis that administration of 2 ml/kg/hr preoperative IV fluids may attenuates postoperative pain.The study was carried out in the Baghdad Teaching Hospital, Al-Yarmok Teaching Hospital and Al-Karama Teaching Hospital from 12 May till 17 June 2009. The total number of patients was 120 (35 males and 85 females) with their age ranged between 10-90 years. The patients were divided into two groups according to administration of preoperative IV fluids, group A (65 patients) did not receive IV fluids and group B (55 patients) received IV fluids preoperatively. Regarding group A, the pain scale was ≤ 5 in 15.3% of patients, and it was >5 in 84.7% of patients and these results obtained within 0-5 hours after awaking from anesthesia. Whereas in group B, the pain scale was ≤5 in 29.09% of patients and was >5 in 70.9% of patients. We have demonstrated that the preoperative administration of 2ml/kg/hr IV fluids (crystalloid) to patients who had fasted from fluids decreased the severity of postoperative pain, and the need for postoperative analgesia. We report for the first time that administration of large volume preoperative IV fluids significantly reduce the incidence and severity of pain in patients at high risk for pain.
Effectiveness of a health improving model on oral health behavior for adolescents by nursing interventions

Information Processing Theory and Improving Health Model by nursing interventions were applied to adolescents with low oral and dental health behavior. The method of study has an experimental design with pre-test and post-test control groups. According to the results of oral health care form, individuals that are chosen from bottom 25% of the attitude scale were placed in the experimental (n=40) and control (n=40) groups randomly. The data were collected by four different forms of which are personal information form, multi-dimensional oral health control scale (MOHLCS), oral health care form (ODHB) and oral examination form. Increased mean internal focus control point which was a sub-scale of MOHLCS scale was found in the experimental group compared to control group. The mean score of ODHB after the post test and re-test between the groups, a statistically significant difference was determined in favor of the experimental group. Conclusions: The nursing attempts that were applied to PenderÂ’s Health Promotion Model and GagneÂ’s Theory of Information Proccessing were effective for improving the oral health behavior.
Trauma counselling: a comprehensive overview for undergraduate and graduate students

Throughout the literature on trauma, various researchers have pointed out the necessity of incorporating trauma education into academic settings. The purpose of this project is to present a comprehensive overview of trauma counselling to undergraduate and graduate students. The twelve sections encompassing this project are the following: (1) What is trauma? (2) Posttraumatic Stress Disorder (PTSD) and symptomatology (3) Complex Trauma in adults and symptomatology (4) Complex Trauma in adolescents and children (5) Assessment of PTSD and Complex Trauma in adults, adolescents, and children (6) PTSD modes of treatments (7) Phases of treatment for PTSD and Complex Trauma (8) Culture and trauma (9) Historical Trauma (10) Intergenerational Trauma (11) Secondary Traumatic Stress, Vicarious Traumatization, and clinician self-care and (12) Coping strategies and Posttraumatic Growth. This project ideally will prepare future clinicians to effectively deal with trauma issues in their clinical work and, ultimately, to provide quality services to trauma survivors. --P.ii.
Evaluating the quality of radiotherapy treatment plans with uncertainty using data envelopment analysis

External beam radiation therapy is a common treatment method for cancer. Radiotherapy is planned with the aim of achieving conflicting goals: while a sufficiently high dose of radiation is necessary for tumour control, a low dose of radiation is desirable to avoid complications in normal, healthy, tissue. This thesis aims to support the radiotherapy treatment planning process for prostate cancer by evaluating the quality of proposed treatment plans relative to previous plans. We develop a variable selection technique, autoPCA, to select the most relevant variables for use in our Data Envelopment Analysis (DEA) models. This allows us to evaluate how well plans perform in terms of achieving the conflicting goals of radiotherapy. We develop the uncertain DEA problem (uDEA) for the case of box uncertainty and show that for small problems this can be solved exactly. This study of uncertainty is motivated by the inherently uncertain nature of the treatment process. Robust DEA, uDEA and simulation are applied to prostate cancer treatment plans to investigate this uncertainty. We identify plans that have the potential to be improved, which clinicians then replan for us. Small improvements were seen and we discuss the potential difference this could make to planning cases that are more complex. To aid this, we develop a prototype software, EvaluatePlan, that assesses the efficiency of a plan compared to past treatment plans.
A STUDY OF ASSESSMENT IN PERIPHERAL NEUROPATHY IN PATIENTS WITH NEWLY DETECTED THYROID DISORDERS IN A TERTIARY CARE TEACHING INSTITUTE

BACKGROUND Thyroid dysfunction is associated with characteristic symptoms, signs and functional alterations in many organs and systems. The purpose of this study was to evaluate objectively the functional changes in the peripheral nervous system and to determine the type and the prevalence of these diseases. The prevalence of neuromuscular disorders related to thyroid dysfunction has been reported to be between 20-80%. AIMS AND OBJECTIVES  To study the correlation and prevalence of nerve conduction abnormalities in patients with thyroid dysfunction.  To determine the type of peripheral neuropathy in these patients. MATERIALS AND METHODS This study was carried out in Medicine OPD and Endocrinology OPD over a period of 8 months; 50 consecutive patients with newly detected thyroid dysfunction and who fulfilled the inclusion criteria were included in the study and the required data were recorded from each subject with an in-person interview by administering a specific questionnaire. Nerve Conduction Study was performed in all these subjects by using the Standard RMS ENMG EP MARK II machine and results were correlated. RESULTS Out of the 50 patients studied 18 patients had neuropathy, of which 14 of them were hypothyroid and 4 of them had hyperthyroidism; 2 patients had mononeuropathy and 16 of them had polyneuropathy. Carpal tunnel syndrome was present in 2 individuals who had hypothyroidism; 14 patients had predominantly sensory neuropathy and 4 individuals had both sensory and motor polyneuropathy. The most common neurological abnormalities detected were sensory axonal polyneuropathy, mononeuropathy involving the sural nerve, mononeuritis multiplex pattern, carpal tunnel syndrome. CONCLUSION This study concludes that hypothyroid patients are more prone to develop neuropathy predominantly involving the sensory nerves of both lower limbs. This study clearly depicts that peripheral nervous system involvement is more often seen in patients with newly detected thyroid dysfunction. Electrophysiological studies help us in the diagnosis of this type of subclinical polyneuropathy. So nerve conduction studies can be included in the early part of diagnostic workup panel in newly detected thyroid illness.
Audit Fees under Alternative Goodwill Accounting Approaches: Evidence from the Adoption of the Impairment-Only Approach in Australia

The International Accounting Standards Board (IASB) constituents expressed concerns about the cost of the impairment-only approach for goodwill accounting under International Financial Reporting Standards (IFRSs). Considering these concerns, the IASB is now reviewing the approach. Motivated by this debate, we examine the association between goodwill and audit fee under two alternative goodwill accounting approaches in Australia – the dual approach under pre-IFRSs Australian Generally Accepted Accounting Principles and the impairment-only approach under IFRSs. We find that goodwill does not have an audit fee-increasing impact under the impairment-only approach than under the dual approach. This result is robust across alternative variable measurements, alternative samples and alternative models. The result is of potential interest to the IASB and its constituents.
Effect of 8 Weeks Rhythmic Aerobic Exercise on Serum Resistin and Body Mass Index of Overweight and Obese Women

Resistin plays an important role in obesity-related diseases through metabolic processes and the immune system. The purpose of this study was to evaluate the effect of 8 weeks aerobic exercise on the amount of resistin and the Body Mass Index (BMI) of overweight women. This study was carried out through semi-experimental method. To this end, 34 overweight and obese women (aged 40±10, BMI≥25) participated in the study voluntarily and were randomly divided into experimental (17) and control (17) groups. The experimental group started the 8-week exercise program performed in three sessions a week (51 minutes per session) with 66% of the maximum heart rate in the first week which gradually and along with the exercise progression increased to 86%. Training sessions began with warming up then continued with the main part of the exercise including low impact and high impact aerobic moves in the standing positions and then back to the sitting initial position. The exercise (experimental) group participated in an 8-week training program (3 sessions a week) while the control group was asked to keep their normal life during the study period as it was before. Blood samples were taken in two stages, first 48 hours before the tests and second 48 hours after the last aerobic training session. Serum resistin concentration was calculated through ELISA (enzyme-linked immunosorbent assay) method using its special kit. The ShapiroWilk test was used to determine the consistency and nature of information about the subjects in the research groups. In order to analyze the data, the paired t-test was used to examine the intra-group differences and covariance test at a significant level of P≤0.05 was performed to measure the inter-group differences. SPSS21 software was also used to conduct statistical calculations. Data analysis indicated that the 8-week exercise program had a significant effect on BMI (P=0/001), body weight (P=0/000), and resistin (P=0/001). In addition to reducing weight and lowering BMI, aerobic exercise can also decrease resistin levels in overweight and obese women which can be indicative of a lower risk of developing metabolic and cardiovascular diseases.
Orthodontists’ and patients’ preferences in website design in the selection of an orthodontic practice: a comparative study

ORTHODONTISTS’ AND PATIENTS’ PREFERENCES IN WEBSITE DESIGN IN THE SELECTION OF AN ORTHODONTIC PRACTICE: A COMPARATIVE STUDY By Taylor R. Brown, D.D.S. A thesis submitted in partial fulfillment of the requirements for the degree of Master of Science in Dentistry at Virginia Commonwealth University. Virginia Commonwealth University, 2018 Thesis Director: Bhavna Shroff, D.D. S, M.D.Sc. Program Director, Department of Orthodontics Objective: To determine which website characteristics are preferred by orthodontists, adult patients, and parents of patients. Materials and Methods: 1,000 active members of the American Association of Orthodontists and 750 active orthodontic patients/parents were sampled. Participants rated the importance of website characteristics, indicated presence of those characteristics on the current website, and ranked sample website images. Preferences were compared between orthodontist and the patient/parent group using t-tests and sample websites were compared using ANOVA models and Tukey’s adjusted post-hoc tests. Significance level was set at 0.05. Results: 11 of the 16 website features showed significant differences between patients/parents and orthodontists. Participants preferred sample websites with images of people, information at the top of the page, and an ‘about the doctor’ page with a greater amount of information. Conclusion: This study showed significant differences in preferences between orthodontists and patients/parents, by gender, and between adult patients and parents of adolescent patients.
How Does the Power of Crowdvoting Affect Purchase Decisions? Effects of Majority and Minority Influence in Online Rating Systems

Online rating systems gather review scores on products from different customers’, creating collective opinions and accumulating the power formed by the crowdvoting. Such the power of the crowdvoting generates two influences: majority and minority influences. Both of which may form a signal that guides or misleads product/service evaluation and in turn purchase decision. This study draws from signaling theory to examine the effects of (1) majority, (2) minority influence and (3) number of reviewers on online shoppers’ perceived product quality and perceived social risk and how they further influence purchase intention. We conducted a scenario-based experiment to test the research model and employed a 2x2x2 full factorial design. A total of 371 undergraduates had participated. The results of this study suggest that majority influence increases perceived product quality and decreases perceived social risk, influencing shoppers’ purchase decision. Implications for theory, practice, and future research directions are discussed.