Miracle-dz/UniFAR-FTUs huggingface dataset:
Effect of a Workplace Weight-Loss Program for Overweight and Obese Healthcare Workers

Purpose: Examining the effect of a workplace weight-loss program on weight loss, and physical, behavioral and mental well-being among overweight/obese healthcare workers. Design: Quasi experimental design Setting: Single healthcare setting Participants: Forty-one (48.0 ± 11.2 years) day-time shift healthcare employees with body mass index [BMI] >29 kg/m2. Intervention: Sixteen-week program with weekly group meetings/activities and individual appointments with nutrition/health experts. Measures: Objective (weight, BMI, blood pressure) and self-reported measures were collected at baseline, conclusion of the intervention and 3 to 6 months post-intervention. Analysis: Repeated measure analysis accounting for confounders. Results: Participants had an average of 13 pounds (5.6%) weight loss (224.2 ± 6.4 vs. 211.6 ± 6.4 lbs.; P < 0.0001) upon program completion with significant decreases in BMI (37.7 ± 1.0 vs. 35.1 ± 1.0 kg/m2; P < 0.0001). Extreme obesity (BMI≥40 kg/m2) rate was reduced from 36.6% to 17.1% (P < 0.0001). There were decreases in diastolic blood pressure (76.0 ± 1.4 vs. 68.7 ± 1.5 mmHg; P = 0.001) and self-reported blood glucose (119.9 ± 4.4 vs. 105.5 ± 4.6 mg/dL; P = 0.03). Participants had improvements in weekly physical activity (25% change; P = 0.01), nutrition behavior (33% change, P < 0.0001), sleep quality (23% change, P = 0.005), and depression (72% change, P < 0.0001). Twenty-seven participants had post-intervention follow-up data. On average participants regained 8 pounds, which was less than the initial weight loss (16 lbs., N = 27). Conclusion: The results suggest the program may benefit healthcare employees. Further emphasis should be placed on post-intervention weight management to prevent weight regain.
Thiamine deficiency in a dog associated with exclusive consumption of boiled sweet potato (Ipomoea batatas): Serial changes in clinical findings, magnetic resonance imaging findings and blood lactate and thiamine concentrations

Abstract Thiamine (vitamin B1) is an essential nutrient that significantly influences ATP production in the body. It needs to be supplemented consistently through an exogenous source to prevent deficiency; however, it is easily affected by a variety of mitigating factors. Additionally, thiamine requirements can be influenced by an individual's dietary composition. The nervous system is particularly vulnerable to thiamine deficiency due to its high metabolic demand. Thiamine deficiency is typically diagnosed based on clinical signs, dietary history and response to thiamine administration. A 5‐year‐old neutered male Maltese Terrier dog presented with an acute onset of seizures and generalized ataxia. The dog was exclusively fed boiled sweet potato (Ipomoea batatas) as a primary diet source for 4 weeks. MR findings and hyperlactatemic conditions were consistent with thiamine deficiency, and the diagnosis was confirmed by measuring thiamine concentrations in blood using high‐performance liquid chromatography (HPLC). Appropriate thiamine supplementation and diet changes resulted in a rapid improvement in neurological signs. Repeated MR imaging 2 weeks after starting the treatment completely resolved the previously identified abnormalities, and repeated measurements of blood lactate and thiamine levels revealed complete recovery of the thiamine‐deficient status.
Striking Patterns in Booid Snakes

Striking is kinematically variable in booid snakes but generally fits one of three patterns. Analysis of slow speed, short-exposure video records of more than 200 strikes in 17 juveniles and subadults of seven species of booids shows that they first hit the prey either with the mandibles (MAN strikes) or with the mandibles and upper jaw together [driving scissors (DSC) strikes], rarely with the upper jaw [palatomaxillary (PMX) strikes]. In MAN strikes, inertia carries the braincase over the prey in an arc whose radius is partly defined by the tip of the mandible. In DSC strikes, both jaws slide over the prey. In both of these strike patterns, much of the impact of prey contact appears to be directed through the mandibles and their suspensoria and adductor muscles. Ventral flexion of the whole head and neck initiates the first constricting coil shortly after contact with the prey and may be aided by reaction forces generated by the prey's inertia. In PMX strikes, on the other hand, the braincase incurs a higher proportion of impact forces and ventral flexion of the head is often delayed. The predominant use of MAN and DSC strikes suggests that these kinematic patterns in combination with tooth geometry may reduce the probability of tooth breakage at the time of jaw impact with the prey. The same tooth geometry increases the probability of snaring in the interval between contact and immobilization by constriction.
Factors Associated with Dietary Control and Physical Activity in the Management of Metabolic Syndrome in Korean Menopausal Women

The increased prevalence of metabolic syndrome (MetS) among menopausal women necessitates successful management strategies such as applying dietary restrictions and engaging in physical activity to improve their health and quality of life. We investigate factors associated with dietary control and physical activity in 564 menopausal Korean women classified as having MetS who partook in the 2016 and 2017 Korean National Health and Nutrition Examination Survey (KNHANES). To determine socio-demographic characteristics, lifestyle features, and MetS-related characteristics associated with dietary control and physical activity, multiple logistic regression analysis was performed. Of the women with MetS 36.1% applied diet control and 39.5% engaged in physical activity. Women who applied dietary control strategies to improve their health were more likely to be in the 40–49 age group (odds ratio (OR): 3.38; 95% confidence interval (CI): 1.25–9.18), to engage in physical activity (OR: 2.24; CI: 1.43–3.52), and to take hypertension medication (OR: 1.66; CI: 1.04–2.67) or diabetes mellitus medication (OR: 2.99; CI: 1.80–4.97). Physically active menopausal women with MetS were more likely to also engage in dieting (OR: 2.32; CI: 1.42–3.51). Accordingly, suggestions can be provided to healthcare workers in designing, not only individual approaches to lifestyle modification but also comprehensive interventions including dietary control and physical activity for menopausal MetS women. Health-care interventions like dietary control, which provide additional support to vulnerable MetS women, should target women aged 60 or above or those who do not take medicines for hypertension and diabetes mellitus.
One single-center cross-sectional investigation on varicella antibody level of all age groups in Chinese people

ABSTRACT Varicella outbreaks were mainly reported in developed regions with high vaccine coverage, but not in undeveloped areas. It is still not clear that whether the published data of varicella epidemiology could reflect the reality in China or not. In 2019, 657 subjects from People’s Hospital of Chongqing Youyang County were included. Anti-varicella-zoster virus (VZV) IgG antibodies were determined by ELISA. The anti-VZV IgG levels were categorized as positive when values were ≥100 mIU/mL. Our results showed that the rates of anti-VZV IgG seropositivity (χ2 = 328.957, P < .0001) and geometric mean titers (P < .0001) were significantly influenced by age. The seropositivity declined dramatically from 84.5% in subjects ≤3 m of age, to 7.9% in subjects of >3 m-1 y (P < .0001). Then, the positivity rate increased slowly as age to 26.7% in >1-<3 y (P = .0006), and 34.5% in 3-<7 y (P = .4294). A steady rise (45.6%) in positivity was observed in subjects aged 7-<18 y. After then, the positivity began to increase robustly. A total of 87.8% of adults aged 18-<40 y had acquired VZV-specific immunity (P < .0001). The highest positivity rate was found in 40-<60 y (98.3%) and ≥60 y (98.2%) group. In conclusion, most subjects of >3 m-<7 y age were susceptible to VZV. The proportion of subjects with natural infection-induced immunity increased with age. Nearly all subjects over 40 ages had positive anti-VZV IgG antibodies, which proved that they were infected by this virus in the past. These results suggested that VarV should be included in the national immunization program in China.
Sequence analysis of gene encoding cyclotides in three species of Violaceae and determination of their anti-microbial activities

Cyclotides are plant peptides, which are characterized by their unique cyclic cysteine knot structure. These peptides have a variety of biological activity including anti-HIV, anti-microbial and cytotoxic effects. In the current study, we compared these gene sequences encoding cyclotides from Viola odorata, V. ignobilis and V. occulta. We also extracted total cyclotides content from V. ignobilis by fractionation method and semipurified these on a SPE-CI8 (Solid Phase Extraction). Anti-microbial activity of the semi-purified cyclotides was determined by radial diffusion assay (RDA). Three groups of bacteria were studied including human pathogenic bacteria, plant pathogenic bacteria and soil benefit bacteria. Three gene encoding cyclotides were identified in studied species. The most susceptible bacterium in human pathogenic group was Staphylococcus aureus. Xanthomonas oryzea was the most susceptible bacterium between the three studied groups.
Species motif extraction using LPBS

This paper presents the use of the Linear-PSO with Binary Search‘ (LPBS) algorithm for discovering motifs, especially species specific motifs.In this study, fragments of mitochondrial cytochrome C oxidase subunit I (COI/COX1) and genome of COI were collected from the Genbank online database.For the first experiment, the genome of COI was used as a reference set and other DNA sequences were used as a comparison set.All the collected DNA sequences are from the same species.The results show that the LPBS algorithm is able to discover motifs. For the second experiment, all the discovered motifs were used as a reference set and the genome of COI from other species were used as a comparison set.The results show that the LPBS algorithm is able to identify correct motifs for species identification.
COVID-19 in 17 Italian Pediatric Emergency Departments

We described the variability of presentation of 170 Italian children and their differences with the previously reported cohorts. BACKGROUND: Variability in presentation of children with coronavirus disease 2019 (COVID-19) is a challenge in emergency departments (EDs) in terms of early recognition, which has an effect on disease control and prevention. We describe a cohort of 170 children with COVID-19 and differences with the published cohorts. METHODS: Retrospective chart reviews on children (0–18 years) evaluated in 17 Italian pediatric EDs. RESULTS: In our cohort (median age of 45 months; interquartile range of 4 months–10.7 years), we found a high number of patients <1 year with COVID-19 disease. The exposure happened mainly (59%) outside family clusters; 22% had comorbidities. Children were more frequently asymptomatic (17%) or with mild diseases (63%). Common symptoms were cough (43%) and difficulty feeding (35%). Chest computed tomography, chest radiograph, and point-of-care lung ultrasound were used in 2%, 36%, and 8% of cases, respectively. Forty-three percent of patients were admitted because of their clinical conditions. The minimal use of computed tomography and chest radiograph may have led to a reduced identification of moderate cases, which may have been clinically classified as mild cases. CONCLUSIONS: Italian children evaluated in the ED infrequently have notable disease symptoms. For pediatrics, COVID-19 may have rare but serious and life-threatening presentations but, in the majority of cases, represents an organizational burden for the ED. These data should not lower the attention to and preparedness for COVID-19 disease because children may represent a source of viral transmission. A clinically driven classification, instead of a radiologic, could be more valuable in predicting patient needs and better allocating resources.
Cardiovascular and Renal Morbidity in Takayasu Arteritis: A Population‐Based Retrospective Cohort Study From the United Kingdom

Cardiovascular disease (CVD) is a major complication and cause of mortality in Takayasu arteritis (TAK), but population‐based controlled studies from the UK are lacking. We undertook the present study to investigate the frequency of morbidity and mortality related to CVD, as well as to cerebrovascular and kidney disease, among patients with TAK in the UK.
Participants’ enactment of behavior change techniques: a call for increased focus on what people do to manage their motivation and behavior

Intervention effectiveness does not only depend on fidelity of intervention delivery, but also the enactment, or use, of behavior change techniques (BCTs) by the participants. For example, it is not sufficient that intervention provider prompts an intervention participant to self-monitor their physical activity, crucially, the participant must also enact self-monitoring. Theoretical and conceptual work integrating various strands of research into 'what a person can do for oneself' to change behavior is needed. This paper argues how this would aid in designing for, assessing, and promoting the use individuals' self-management techniques, and ultimately, our understanding of sustained behavior change. The recently published, integrative compendium of self-enactable techniques to change and self-manage motivation and behavior can act as a useful starting point for this work. An increased focus on the enactment of BCTs would help clarify intervention processes, help explain trial outcomes, and potentially enhance intervention effectiveness.
Downregulation of Inflammatory Cytokine Release from IL-1β and LPS-Stimulated PBMC Orchestrated by ST2825, a MyD88 Dimerisation Inhibitor

The inflammatory process implicates homeostasis disruption and increased production of inflammatory mediators. Myeloid differentiation primary response 88 (MyD88) is an essential protein recruited after lipopolysaccharide (LPS) and interleukin (IL)-1β stimulation, a process that converges in nuclear factor kappa B (NF-κB) activation, as well as a transcription of several genes of both pro- and anti-inflammatory cytokines. The inhibition of MyD88 has shown efficacy by decrease inflammatory response, and has demonstrated potential application as a therapeutic target in chronic diseases. In this study, we investigate the effect of MyD88 dimerisation inhibitor ST2825 on cytokine production from rhIL-1β and LPS-stimulated peripheral blood mononuclear cells (PBMC) from healthy blood donors (HBD). ST2825 significantly downregulates the production of IFN-γ, IL-6, IL-12, IL-2, IL-15, IL-7, VEGF, IL-1Ra, IL-4, IL-5, IL-13 and IL-9 (p < 0.05) in LPS-stimulated PBMC. Moreover, ST2825 had a relatively low impact on IL-1β signalling pathway inhibition, showing that only a few specific cytokines, such as IFN-γ and IL-1Ra, are inhibited in rhIL-1β-stimulated PBMC (p < 0.01). In conclusion, MyD88 dimerisation inhibitor ST2825 showed high efficacy by inhibiting pro- and anti-inflammatory cytokine production in LPS-stimulated PBMC. Moreover, although rhIL-1β induced a sustained cytokine production (p < 0.05), ST2825 did not show a significant effect in the secretion of neither pro- nor anti-inflammatory cytokines in rhIL-1β-stimulated PBMC.
Urgent Pericardiocentesis Is More Frequently Needed After Left Circumflex Coronary Artery Perforation

Background: Coronary artery perforation (CAP) is a rare but potentially life-threatening complication of percutaneous coronary interventions (PCIs) due to the risk of cardiac tamponade. Strikingly, in contrast to numerous analyses of CAP predictors, only few studies were focused on the predictors of tamponade after PCI, once iatrogenic CAP has occurred. Our aim was to search for clinical and periprocedural characteristics, including the coronary artery involved, associated with the development of acute cardiac tamponade among patients experiencing CAP. Methods: From the medical records of nine centers of invasive cardiology in southern Poland, we retrospectively selected 81 patients (80% with acute myocardial infarction) who had iatrogenic CAP with a visible extravasation jet during angiography (corresponding to type III CAP by the Ellis classification, CAPIII) over a 15-year period (2005–2019). Clinical, angiographic and periprocedural characteristics were compared between the patients who developed acute cardiac tamponade requiring urgent pericardiocentesis in the cathlab (n = 21) and those with CAPIII and without tamponade (n = 60). Results: CAPIII were situated in the left anterior descending artery (LAD) or its diagonal branches (51%, n = 41), right coronary artery (RCA) (24%, n = 19), left circumflex coronary artery (LCx) (16%, n = 13), its obtuse marginal branches (7%, n = 6) and left main coronary artery (2%, n = 2). Acute cardiac tamponade occurred in 24% (10 of 41), 21% (4 of 19) and 37% (7 of 19) patients who experienced CAPIII in the territory of LAD, RCA and LCx, respectively. There were no significant differences in the need for urgent pericardiocentesis (37%) in patients with CAPIII in LCx territory (i.e., the LCx or its obtuse marginal branches) compared to CAPIII in the remaining coronary arteries (23%) (p = 0.24). However, when CAPIII in the LCx were separated from CAPIII in obtuse marginal branches, urgent pericardiocentesis was more frequently performed in patients with CAPIII in the LCx (54%, 7 of 13) compared to subjects with CAPIII in an artery other than the LCx (21%, 14 of 68) (p = 0.03). The direction of this tendency remained consistent regardless of CAP management: prolonged balloon inflation only (n = 26, 67% vs. 13%, p = 0.08) or balloon inflation with subsequent stent implantation (n = 55, 50% vs. 24%, p = 0.13). Besides LCx involvement, no significant differences in other characteristics were observed between patients according to the need of urgent pericardiocentesis. Conclusions: CAPIII in the LCx appears to lead to a higher risk of acute cardiac tamponade compared to perforations involving other coronary arteries. This association may possibly be linked to distinct features of LCx anatomy and/or well-recognized delays in diagnosis and management of LCx-related acute coronary syndromes.
Characteristics of the inner retinal layer in the fellow eyes of patients with unilateral exudative age-related macular degeneration

Objective To investigate the thicknesses of the ganglion cell-inner plexiform layer (GC-IPL) and retinal nerve fiber layer (RNFL) of the fellow eyes of patients with unilateral exudative age-related macular degeneration (AMD). Methods A total of 107 patients with unilateral exudative AMD [34 of typical choroidal neovascularization (tCNV), Group A; 73 of polypoidal choroidal vasculopathy (PCV), Group B] and 73 normal control eyes (Group C) were included. Drusen and subretinal drusenoid deposits were assessed in all participants using fundus photography, autofluorescence, and optical coherence tomography (OCT). The GC-IPL and RNFL thicknesses were measured using Cirrus HD-OCT and compared among groups. Linear regression analyses were used to evaluate the factors associated with GC-IPL thicknesses. Results The average GC-IPL thicknesses of Groups A, B, and C were 77.09 ± 3.87, 80.10 ± 6.61, and 80.88 ± 6.50 μm, respectively (p = 0.022). Sectoral GC-IPLs and central macular thicknesses (CMTs) were significantly different among groups (all, p <0.05), whereas none of the RNFL parameters differed significantly (all, p >0.05). Multivariate linear regression analyses revealed that age (p <0.001), CMT (p <0.001), and tCNV (p = 0.013) were significantly associated with average GC-IPL thickness, and the rate of reduction of GC-IPL thickness with increasing age in the fellow eyes of tCNV patients was higher than those in the PCV and control groups. Conclusions Unilateral tCNV patients exhibited statistically significant reduction of the GC-IPL thickness in the fellow eyes, compared to values of the fellow eyes of unilateral PCV patients or control patients. RNFL values trended to be lower but did not reach statistical significance.
The relationships between self-compassion, rumination, and depressive symptoms among older adults: the moderating role of gender

Abstract Objectives Depression is a significant mental health issue for older adults. Rumination is a key risk factor for depressive symptoms, and self-compassion is a protective factor. The aim of the current study was to test the processes by which self-compassion might act as a protective factor among older adults by investigating a mediation model, and whether the model is conditional on gender. It was hypothesised that self-compassion and its six components (self-kindness, common humanity, mindfulness, self-judgement, isolation, and over-identification) would be indirectly associated with depressive symptoms via rumination. Method A sample of 135 older Australian women and 106 older Australian men aged between 65 and 89 years completed the Centre for Epidemiologic Studies Depression Scale, the Ruminative Thought Style Questionnaire, and the Self-Compassion Scale. Results Results supported the mediation models for self-compassion for both men and women, however, support for the models involving the individual components of self-compassion varied according to gender. The mediation effects were stronger for women than men. Conclusion Interventions aimed at increasing self-compassion might have benefits for older adults. Future research investigating whether tailoring interventions according to gender of participants is efficacious is needed.