Miracle-dz/UniFAR-FTUs huggingface dataset:
Modified Dose of Radioactive Iodine Therapy in a Patient With Thyroid Cancer on Peritoneal Dialysis: Case Report and Review of Literature

Thyroid malignancy is common among patients with renal impairment compared with the general population. Treatment involves surgical resection and radioactive iodine therapy (RAI) in high-risk patients. As a result of impaired iodine clearance in those with no residual kidney function, the determination of appropriate iodine dose is challenging. Evidence is lacking, and all previous reports are based on case studies with no universally accepted protocol. We describe the case of a 30-year-old woman with end-stage renal disease on peritoneal dialysis (PD) who was diagnosed with papillary thyroid cancer while undergoing a pre-kidney transplant workup. She had a total thyroidectomy with modified radical neck dissection followed by a reduced-dose radioactive iodine therapy of 30 mCi based on her residual kidney function. Her PD prescription was adjusted to achieve a 2 L ultrafiltration daily. One year follow-up confirmed no evidence of residual nor recurrent disease. High-risk patients with differentiated thyroid malignancy require adjuvant radioactive iodine therapy. The optimal dose of RAI in the end-stage renal disease population is controversial. There are no clear guidelines available for patients with end-stage kidney disease including patients on peritoneal dialysis. Reduced dose therapy is probably effective in achieving the goals of therapy, with lower toxic risk to internal organs. Determining the appropriate schedule of each dialysis session in relation to RAI, the specific replacement prescription, and establishing a safe environment for medical staff dealing with such patients is important to consider. This article aims to highlight the need to establish a standardized protocol among patients with reduced kidney function treated with iodine therapy.
Analysis of Intellectual Capital and Organizational Culture on Employee Performance in Creative Industry Wedding Organizer Surabaya City

The purpose of this study is to examine how organizational culture and intellectual capital affect employee performance in Surabaya City's creative wedding organizer sector. This study employs a quantitative methodology. Data collection to be used in this research is through the use of questionnaires and a Likert scale of 1 to 5 in the scoring calculation of the questionnaire. The sampling method used in this research is the purposive sampling method, and we obtained five wedding organizer businesses in Surabaya City with a sample of 56 respondents determined using the Slovin formula. The data were analyzed using Partial Least squares (PLS). The findings of this study demonstrate that the variable of organizational culture has a favorable and significant impact on worker performance. Employee performance is positively and significantly impacted by the intellectual capital variable. Of the three aspects of intellectual capital, the structural capital component is more prominent than the human capital and relational capital dimensions.
COVID-19 pandemic and addiction: a two-way impact – review reports

Introduction and Objective. The Covid-19 pandemic had a significant impact on our lives and health. At that time, people were looking for ways to reduce stress. One way to escape from problems turned out to be the use of harmful substances – cigarettes, alcohol, drugs or the Internet. Long-term use of these substances leads to addiction. However, the relationship between the Covid-19 pandemic and addiction is not unidirectional. The purpose of the following paper was to review reports on the bidirectional
Historical changes in lake ice‐out dates as indicators of climate change in New England, 1850–2000

Various studies have shown that changes over time in spring ice‐out dates can be used as indicators of climate change. Ice‐out dates from 29 lakes in New England (USA) with 64 to 163 years of record were assembled and analysed for this study. Ice‐out dates have become significantly earlier in New England since the 1800s. Changes in ice‐out dates between 1850 and 2000 were 9 days and 16 days in the northern/mountainous and southern regions of New England respectively. The changes in the ice‐out data over time were very consistent within each of the two regions of New England, and more consistent than four air‐temperature records in each region. The ice‐out dates of the two regions had a different response to changes in air temperature. The inferred late winter–early spring air‐temperature warming in both regions of New England since 1850, based on linear regression analysis, was about 1.5°C. Published in 2002 by John Wiley & Sons, Ltd.
Lipoprotein(a) as a Risk Factor for Cardiovascular Diseases: Pathophysiology and Treatment Perspectives

Cardiovascular disease (CVD) is still a leading cause of morbidity and mortality, despite all the progress achieved as regards to both prevention and treatment. Having high levels of lipoprotein(a) [Lp(a)] is a risk factor for cardiovascular disease that operates independently. It can increase the risk of developing cardiovascular disease even when LDL cholesterol (LDL-C) levels are within the recommended range, which is referred to as residual cardiovascular risk. Lp(a) is an LDL-like particle present in human plasma, in which a large plasminogen-like glycoprotein, apolipoprotein(a) [Apo(a)], is covalently bound to Apo B100 via one disulfide bridge. Apo(a) contains one plasminogen-like kringle V structure, a variable number of plasminogen-like kringle IV structures (types 1–10), and one inactive protease region. There is a large inter-individual variation of plasma concentrations of Lp(a), mainly ascribable to genetic variants in the Lp(a) gene: in the general po-pulation, Lp(a) levels can range from <1 mg/dL to >1000 mg/dL. Concentrations also vary between different ethnicities. Lp(a) has been established as one of the risk factors that play an important role in the development of atherosclerotic plaque. Indeed, high concentrations of Lp(a) have been related to a greater risk of ischemic CVD, aortic valve stenosis, and heart failure. The threshold value has been set at 50 mg/dL, but the risk may increase already at levels above 30 mg/dL. Although there is a well-established and strong link between high Lp(a) levels and coronary as well as cerebrovascular disease, the evidence regarding incident peripheral arterial disease and carotid atherosclerosis is not as conclusive. Because lifestyle changes and standard lipid-lowering treatments, such as statins, niacin, and cholesteryl ester transfer protein inhibitors, are not highly effective in reducing Lp(a) levels, there is increased interest in developing new drugs that can address this issue. PCSK9 inhibitors seem to be capable of reducing Lp(a) levels by 25–30%. Mipomersen decreases Lp(a) levels by 25–40%, but its use is burdened with important side effects. At the current time, the most effective and tolerated treatment for patients with a high Lp(a) plasma level is apheresis, while antisense oligonucleotides, small interfering RNAs, and microRNAs, which reduce Lp(a) levels by targeting RNA molecules and regulating gene expression as well as protein production levels, are the most widely explored and promising perspectives. The aim of this review is to provide an update on the current state of the art with regard to Lp(a) pathophysiological mechanisms, focusing on the most effective strategies for lowering Lp(a), including new emerging alternative therapies. The purpose of this manuscript is to improve the management of hyperlipoproteinemia(a) in order to achieve better control of the residual cardiovascular risk, which remains unacceptably high.
Impacts of Conditional Cash Transfers on Fish Consumption: Evidence from Tanzania

Poverty reduction and conservation of natural resources are both global goals for sustainable development. However, it is not well understood how interventions to reduce poverty impact coastal communities and the fisheries they depend upon. This study explores the impact of a conditional cash transfer (CCT) program in Tanzania on local fish consumption decisions. To overcome the endogeneity of poverty to dependence on fisheries, we exploit a randomized controlled trial implemented in the initial rollout of the CCT. We allow for heterogeneous impacts based on initial household wealth and find that CCT participation increases demand for the poorest households in our study. We also differentiate by types of fish and find that dagaa—a low-value fish common in Tanzania—is primarily driving changes in fish consumption.
A History of the Ancient Southwest

According to archaeologist Stephen H. Lekson, much of what we think we know about the Southwest has been compressed into conventions and classifications and orthodoxies. This book challenges and reconfigures these accepted notions by telling two parallel stories, one about the development, personalities, and institutions of Southwestern archaeology and the other about interpretations of what actually happened in the ancient past. While many works would have us believe that nothing much ever happened in the ancient Southwest, this book argues that the region experienced rises and falls, kings and commoners, war and peace, triumphs and failures. In this view, Chaco Canyon was a geopolitical reaction to the "Colonial Period" Hohokam expansion and the Hohokam "Classic Period" was the product of refugee Chacoan nobles, chased off the Colorado Plateau by angry farmers. Far to the south, Casas Grandes was a failed attempt to create a Mesoamerican state, and modern Pueblo people--with societies so different from those at Chaco and Casas Grandes--deliberately rejected these monumental, hierarchical episodes of their past. (From the Publisher: The second printing of A History of the Ancient Southwest has corrected the errors noted below. SAR Press regrets an error on Page 72, paragraph 4 (also Page 275, note 2) regarding "absolute dates. " "50,000 dates" was incorrectly published as "half a million dates. " Also P. 125, lines 13-14: "Between 21,000 and 27,000 people lived there" should read "Between 2,100 and 2,700 people lived there. ")
Rep2former: a classification model enhanced via reparameterization and higher-order spatial interactions

Abstract. We aim to enhance the ConvNext model using high-order spatial interactions and structural reparameterization techniques. By comparing with current mainstream convolutional neural networks and Transformer models, a more efficient model structure named Rep2former was designed. The proposed model retains efficient spatial interaction capabilities while avoiding the problem of quadratic complexity, which is achieved by not using self-attention. Furthermore, a balanced adjustment was made in parameter quantity, floating-point operations per second, and accuracy to ensure that the model is suitable for deployment in applications. Experimental evaluations and comparisons were conducted on the ImageNet-1k and CIFAR-10 datasets. The results indicate that the Rep2former model outperformed popular models such as ResNet-50, Swin Transformer, and ConvNext in terms of parameter quantity, computational complexity, and accuracy. Therefore, the proposed model is considered more effective and user-friendly.
Predictive Performance of Scoring Systems for Mortality Risk in Patients with Cryptococcemia: An Observational Study

Cryptococcal infection is usually diagnosed in immunocompromised individuals and those with meningeal involvement, accounting for most cryptococcosis. Cryptococcemia indicates a poor prognosis and prolongs the course of treatment. We use the scoring systems to predict the mortality risk of cryptococcal fungemia. This was a single hospital-based retrospective study on patients diagnosed with cryptococcal fungemia confirmed by at least one blood culture collected from the emergency department covering January 2012 and December 2020 from electronic medical records in the Taichung Veterans General Hospital. We enrolled 42 patients, including 28 (66.7%) males and 14 (33.3%) females with a mean age of 63.0 ± 19.7 years. The hospital stay ranged from 1 to 170 days (a mean stay of 44.4 days), and the overall mortality rate was 64.3% (27/42). In univariate analysis, the AUC of ROC for MEWS, RAPS, qSOFA, MEWS plus GCS, REMS, NEWS, and MEDS showed 0.833, 0.842, 0.848, 0.846, 0.846, 0.878, and 0.905. In the multivariate Cox regression analysis, all scoring systems, older age, lactate, MAP, and DBP, indicated significant differences between survivor and non-survivor groups. Our results show that all scoring systems could apply in predicting the outcome of patients with cryptococcal fungemia, and the MEDS displays the best performance. We recommend a further large-scale prospective study for patients with cryptococcal fungemia.
Pengaruhkomposisi Media Tanam Dantakaran Air Cucian Berasterhadap Pertumbuhan Dan Hasil Tanaman Kubis Bunga (Brassica Oleracea Botrytis L.)

Penelitianinidilaksanakanuntukmengetahuikomposisi media tanamdanpemberian air cucianberasterhadappertumbuhandanhasilkubisbunga(Brassica oleraceavar,botrytis L.)dataranrendah. Penelitiandilaksanakan di DesaTamansariKecamatanTlogowunguKabupatenPati,Jawa Tengah, terletakpadaketinggian rata-rata 15,5 meter diataspermukaan air laut, beriklimtropisdanjenistanahlatosolcokelatdengan pH berkisar 6,5. Waktupelaksanaanpenelitian di mulaidaribulanmeisampaijuli 2014. Penelitiandilakukan di dalam Polybag denganmenggunakanpercobaanfaktorialberdasarpadaRancanganAcakKelompokLengkap (RAKL) yang terdiridari 2 faktordan 3 ulangansertadenganfaktordan level masing-masingsebagiberikut ,Faktor I : komposisi media tanam (M), terdiridari 5 level, yaitu :M0 = Media tanah,M1 = Media tanah,sekam ,pupukkandangdenganperbandingan = 2:1:1, M2 = Media tanah,sekam , pupukkandangdenganperbandingan = 1:2:1, M3 = Media tanah,sekam ,pupukkandangdenganperbandingan = 1:1:2. Faktor II : Dosispemberiaantakaran air cucianberas (A) terdiridari level 4,yaitu : A0 = tanpapemberian air cucianberas A1 = takaranpenyiraman air cucianberas 200 ml A2 = takaranpenyiraman air cucianberas 250 ml A3 = takaranpenyiraman air cucianberas 300 ml. Sehingga di dapatkan 16 kombinasiperlakuaan. Komposisi media tanamberpengaruhsangatnyata pada tinggi tanaman sejak umur 5 MST sampai 10 MST serta jumlah daun sejak umur 4 MST sampai 10 MST. Diketahui pula, bahwa komposisi media tanam yang berupa campuran tanah, sekam dan pupuk kandang sapi denagn nisbah 1:1:2 menghasilkan panjangakar primer,diameter dan bobot bunga per tanaman,bobotbrangkasansegarmaupun kering terbaik. Pemberian aircucianberasberpengaruhsangatnyatapadapanjangakar primer, diameterdan bobotbunga, bobotbrangkasansegardankering. Pemberian air cucianberasdenganvolume 300 ml berpengaruhsangatnyataterhadap tinggi tanaman sejak umur 5 MST sampai 10 MST dan berpengaruh nyata terhadapjumlahdaun padasetiapumurtanaman. Kombinasiperlakuaankomposisi media tanamyang berupa campuran tanah, sekam, :pupukkandang sapi dengan nisbah 1:1:2 danvolumepemberian air cucianberassebesar 300 ml (M3A3) menunjukanhasilterbaikuntuksetiap parameter pengamatan. Adapun kombinasiperlakuaankomposisi media tanamtanah:sekam:pupukkandang sapi dengan perbandingan 1:1:2 danvolumepemberian air cucianberassebesar 200 ml (M3A1)memberikanhasilkombinasiterbaikuntukjumlahdaun. Selanjutnya, terjadiinteraksisangatnyataantarakomposisi media tanamdanvolume pemberian air cucianberaspadasetiap parameter yang diamati.
Nurses’ Burden of Elimination Care: Sequential Explanatory Mixed-Methods Design

Background Inpatients commonly experience problems with elimination due to incontinence, urinary retentions, and complications with indwelling catheters. Although elimination care (EC) is an important nursing area, few studies explore the burden of EC on nurses. Aim To identify the burden on EC by analyzing nurses’ opinions using sequential explanatory mixed method. Methods This research was conducted using a sequential explanatory mixed-methods design. A total of 59 nurses at a tertiary hospital in South Korea participated in the study from January 1 to March 31, 2022. For quantitative analysis, information about number of delays of work due to EC, required time for serving bedpan or diaper changes, percentage of EC per shift, and percentage of patients who need EC was collected through a survey. For qualitative analysis, focus group interviews were conducted to identify factors that put a burden on EC. Important themes were derived by analyzing nurses’ opinions on EC. Results For nurses in intensive care units, general wards, and integrated nursing care wards, the number of work delays due to EC was 3.6 ± 1.5, 2.3 ± 1.2, and 4.8 ± 2.4 (p<0.01), respectively. The mean percentage of EC work out of total nursing tasks per shift was 36.2 ± 19.0, 29.3 ± 14.4, and 43.8 ± 14.1 (p=0.02), respectively. The mean percentage of patients requiring EC out of patients a nurse cares was 85.4 ± 16.6, 41.3 ± 26.1, and 58.8 ± 21.9 (p<0.01), respectively. Following qualitative analysis, four themes related to nurses’ EC burden were derived: physical burden, frequent care needs, delay of other jobs due to EC, and complications. Among them, frequent care needs were found to be the primary factor requiring consideration to reduce nurses’ burden. Conclusion This research found that EC is one of the most burdensome tasks that nurses want to avoid. To alleviate their burden, effective EC protocol or smart medical devices assisting with EC should be developed.
Elucidating the direct effects of the novel HDAC inhibitor bocodepsin (OKI-179) on T cells to rationally design regimens for combining with immunotherapy

Histone deacetylase inhibitors (HDACi) are currently being explored for the treatment of both solid and hematological malignancies. Although originally thought to exert cytotoxic responses through tumor-intrinsic mechanisms by increasing expression of tumor suppressor genes, several studies have demonstrated that therapeutic responses depend on an intact adaptive immune system: particularly CD8 T cells. It is therefore critical to understand how HDACi directly affects T cells in order to rationally design regimens for combining with immunotherapy. In this study, we evaluated T cell responses to a novel class-selective HDACi (OKI-179, bocodepsin) by assessing histone acetylation levels, which revealed rapid responsiveness accompanied by an increase in CD4 and CD8 T cell frequencies in the blood. However, these rapid responses were transient, as histone acetylation and frequencies waned within 24 hours. This contrasts with in vitro models where high acetylation was sustained and continuous exposure to HDACi suppressed cytokine production. In vivo comparisons demonstrated that stopping OKI-179 treatment during PD-1 blockade was superior to continuous treatment. These findings provide novel insight into the direct effects of HDAC inhibitors on T cells and that treatment schedules that take into account acute T cell effects should be considered when combined with immunotherapies in order to fully harness the tumor-specific T cell responses in patients.
Innovational Leadership and Knowledge Sharing: The Mediator Role of Self-efficacy

Abstract: Innovational leadership is a set of practices and skills that leaders develop to promote innovative behaviors in their workers at the individual and collective levels. This is a novel concept focused on one role of leaders: the facilitation of the generation of new or significantly improved products and services. Previous studies with other styles of leadership have shown that transformational leadership encourages a climate for innovative work behaviors, while transactional leadership influences exploitative innovation activities. Knowledge sharing involves the transfer of experience and expertise to facilitate business development and the accomplishment of organizational objectives. Self-efficacy is an individual´s confidence in their abilities to execute a particular task. It influences learning and performance. This research studied whether innovational leadership influences two types of knowledge sharing: tacit and explicit. At the same time, the role of self-efficacy as a mediator variable was evaluated. The sample consisted of 415 workers from different sectors in Colombia. According to the results, innovational leadership positively influenced tacit and explicit knowledge, although the effect on tacit knowledge was higher. Finally, self-efficacy played a mediator role in the relationship between innovational leadership and knowledge sharing. Additional research is suggested to explore the differences between innovational leadership and other types of leadership in the process of sharing tacit and explicit knowledge. At the same time, complementary investigations about the dynamics of innovational leadership are needed to understand why it affects more tacit knowledge than explicit knowledge.
Overview of spark plasma synthesis and sintering of MgB2 superconductor

This study aims to investigate the sintering mechanisms of magnesium diborides using spark plasma sintering and optimize the sintering process conditions. Three different precursor materials were used: (i) commercial powder MgB2, (ii) mixtures of magnesium and nano boron powder (Mg + 2B), and (iii) mixtures of Mg and MgB4 powder for an ‘in-situ’ reactive synthesis. The density of the obtained bulks exceeds 90% of the theoretical density of the material. The structure and microstructure of the samples were analyzed using x-ray diffraction and scanning electron microscope, which were correlated with their superconducting properties. The critical current density (J c), pinning force (f p), and electrical resistivity (ρ) of the samples were also investigated. The results show that the in-situ reactive synthesis of MgB2 using magnesium and nano boron powder was the most effective method for producing high-quality samples with improved superconducting properties. The findings could lead to the development of more efficient methods for producing high-performance of MgB2 bulks.
Influence of Technological Readiness on the Performance of E-Businesses in Kenya

The purpose of this study was to investigate the effect of technological readiness on the performance of e-business in Kenya. The study was anchored on the resource-based view theory and it adopted a positivist philosophical worldview and limited itself to quantitative methods. The study population was 112 registered e-business companies in Nairobi and the units of analysis were the 336 management-level employees of the companies. The study adopted the use of questionnaires to acquire data from respondents. The study used the census sampling technique where all the 112 registered e-business companies in Nairobi were included in the study. Both descriptive and inferential statistics were used to analyze the data. Means and standard deviations were generated from the descriptive statistical analysis and regression analysis was among the inferential statistics used in the study. The study findings established that technological readiness had a significant influence on the financial performance of e-businesses in Nairobi Kenya (β = 0.300, p < 0.05). Thus, the study concludes that technological preparedness was vital for the performance of e-business in Nairobi Kenya. The study, therefore, recommends that e-business leaders ensure their platforms develop features to enable customers to compare different product prices and have diversified offerings providing discounted prices and premium prices with added features and improved services.