Miracle-dz/UniFAR-FTUs huggingface dataset:
Fuzzy Logic Based PID Auto Tuning Method of QNET 2.0 VTOL

—Unmanned aerial vehicles (UAVs) have gained a lot of attention from researchers due to their hovering and vertical take-off and landing. Different techniques and methods are being employed to implement UAVs. The QNET 2.0 VTOL board, specially designed for NI ELVIS II, is an important platform in the field of unmanned aerial vehicles (UAV). It is a helpful tool to demonstrate the essentials of vertical take-off and landing flight control (VTOL) at educational institutes. The PID controller installed in QNET 2.0 VTOL board is manually tuned is usually done by a skilled operator. This process of tuning is time-consuming and requires an expert’s knowledge. Although PID control of various systems has been reported in the literature, its use is limited in nonlinear systems. For nonlinear systems. Fuzzy logic is suitable due to its nonlinearity capability. The purpose of this research is to study the dynamics of the QNET 2.0 VTOL model, simulate the flight control model in Lab-VIEW and to design an auto-tuned PID controller using Fuzzy logic for QNET 2.0 VTOL model in LabVIEW environment. This study
Discrete explorations of multicellular growth and morphogenesis

It was a new, and somewhat scary adventure for me to start working in a mathematical environment: after my undergraduate studies in biology, I had worked on problems in theoretical biology in computer science, biology, and physics institutes, but never had I been so close to “real” mathematicians. I joined CWI via the Netherlands Consortium for Systems Biology in September 2008, and became part of MAC-4, the Life Sciences group. Would the mathematicians not frown upon our simulation methods? Our methods help develop new hypotheses for biologists, show how complex biological phenomena can be driven by simple underlying rules, and also produce beautiful pictures, but they do not produce any real proofs or theorems. My worries were quickly taken away after having received a warm welcome at CWI, and after the introduction to Jan Karel Lenstra. The original Escher print in Jan Karel’s office made me feel more at ease among mathematicians. The mathematics of life and biological morphogenesis is prominent in the work of M.C. Escher: apart from the metamorphosis from fish to bird in Jan Karel’s office, Escher made many lizard tessellations, and of course the Pedalternorotandomovens centroculatus articulosus the cute rolling creature similar to the extant pill millipede (Figure 1). Later on I learned that Jan Karel had been one of the main proponents of building a Life Sciences group at CWI, and also helped to establish the Netherlands Institute for Systems Biology that ensures that the models, simulation, and methods are developed in collaboration with experimental biologists, so they are applied to “real life” applications.
The Impact of Expert Systems on Enhancing the General Controls over the Computerized Accounting Information Systems

This study aimed to identify the impact of expert systems in improving the general controls of computerized accounting information systems in the Jordanian industrial public shareholding companies listed in Amman Stock Exchange. To achieve this goal, the researchers depended on the descriptive and analytical approaches. The study population consisted of all Jordanian industrial public shareholding companies and the study sample was selected from companies using the expert systems, numbering 32 companies. A questionnaire was formulated and 140 copies were distributed. SPSS was used to analyze data. The researchers found that there is an impact of expert systems in improving the general controls of the computerized accounting information systems four pillars, regulatory controls , access controls, controls the security of files, and documentation of controls and the development and maintenance of devices. Based on the result, the researchers recommended that there is a need of developing training programs for the staff of the Jordanian industrial companies to increase their awareness and understanding of the uses of expert systems, as this could assist them in avoiding errors during system use and consequently lead to strengthening general controls in the companies.
Pediatric Brainstem Encephalitis Outbreak Investigation with Metagenomic Next-Generation Sequencing

In 2016, Catalonia experienced a pediatric brainstem encephalitis outbreak caused by enterovirus A71 (EV-A71). Conventional testing identified EV in peripheral body sites, but EV was rarely identified in cerebrospinal fluid (CSF). RNA was extracted from CSF (n=20), plasma (n=9), stool (n=15) and nasopharyngeal samples (n=16) from 10 children with brainstem encephalitis or encephalomyelitis and 10 contemporaneous pediatric controls with presumed viral meningitis or encephalitis. Unbiased complementary DNA libraries were sequenced, and microbial pathogens were identified using a custom bioinformatics pipeline. Full-length virus genomes were assembled for phylogenetic analyses. Metagenomic next-generation sequencing (mNGS) was concordant with qRT-PCR for all samples positive by PCR (n=25). In virus-negative samples (n=35), mNGS detected virus in 28.6% (n=10), including 5 CSF samples. mNGS co-detected EV-A71 and another EV in 5 patients. Overall, mNGS increased the proportion of EV-positive samples from 42% (25/60) to 57% (34/60) (McNemar’s test; p-value = 0.0077). For CSF, mNGS doubled the number of pathogen-positive samples (McNemar’s test; p-value = 0.074). Using phylogenetic analysis, the outbreak EV-A71 clustered with a neuroinvasive German EV-A71 isolate. Brainstem encephalitis specific, non-synonymous EV-A71 single nucleotide variants were not identified. mNGS demonstrated 100% concordance with clinical qRT-PCR of EV-related brainstem encephalitis and significantly increased the detection of enteroviruses. Our findings increase the probability that neurologic complications observed were virus-induced rather than para-infectious. A comprehensive genomic analysis confirmed that the EV-A71 outbreak strain was closely related to a neuroinvasive German EV-A71 isolate. There were no clear-cut viral genomic differences that discriminated between patients with differing neurologic phenotypes.
Effects of male age and female presence on male associations in a large, polygynous mammal in southern India

We present here, the first detailed study of adult male associations in an Asian elephant population, using six years of data collected on identified males. As expected in a large, polygynous species, adult males spent greater proportions of their time solitarily or in mixed-sex groups than in all-male groups. However, the adult male associations seen were complex, with different patterns of male associations based on their age and on the presence or absence of females. Old and young males spent more time associating with their age-peers and less time associating across age classes than expected at random in the absence of females. Young males did not spend a greater proportion of their time with old males than with young males. Young males did not initiate associations with old males to a greater extent than old males approaching young males. Moreover, male age was not correlated with centrality measures in association networks and was negatively correlated with the number of unique associates per time in the absence of females. All of these suggest that male associations in female absence are primarily a means for males to test strengths against age-peers rather than an opportunity for social learning from old males. Male associations in female presence were rarer than in female absence, and old, reproductively competitive, males avoided each other in female presence, resulting in different male association network properties. Although male associations were generally weak and not stable across years, there were some significant associations. Overall, there was a smaller proportion of time spent in all-male groups, smaller group sizes, and a limited role of older males in the association network in the Kabini Asian elephant population compared to the phylogenetically closely related African savannah elephant. These differences may be related to differences in resource distributions in the two habitats.
Cell-wide web of cytoplasmic nanocourses coordinates calcium signalling

1. POSTER PRESENTATION Duan J, Navarro-Dorado J., Evans AM (2016). Strategic positioning of chromatin anchoring NET protein complexes in the nuclear invaginations of pulmonary arterial smooth muscle cells. Proc Physiol Soc 37, PCAA303 (2016) Physiology 2016, sponsored by the Physiological Society Convention Centre Dublin, Ireland 29—31 July 2016 2. POSTER PRESENTATION Duan J, Navarro-Dorado J., Evans AM (2017) Strategic positioning of chromatin anchoring NET protein complexes in the nuclear invaginations of pulmonary arterial smooth muscle cells
Diagnostic value of blood gene expression-based classifiers as exemplified for acute myeloid leukemia

ABSTRACT Acute Myeloid Leukemia (AML) is a severe, mostly fatal hematopoietic malignancy. Despite nearly two decades of promising results using gene expression profiling, international recommendations for diagnosis and differential diagnosis of AML remain based on classical approaches including assessment of morphology, immunophenotyping, cytochemistry, and cytogenetics. Concerns about the translation of whole transcriptome profiling include the robustness of derived predictors when taking into account factors such as study- and site-specific effects and whether achievable levels of accuracy are sufficient for practical use. In the present study, we sought to shed light on these issues via a large-scale analysis using machine learning methods applied to a total of 12,029 samples from 105 different studies. Taking advantage of the breadth of data and the now much improved understanding of high-dimensional modeling, we show that AML can be predicted with high accuracy. High-dimensional approaches - in which multivariate signatures are learned directly from genome-wide data with no prior biological knowledge - are highly effective and robust. We explore also the relationship between predictive signatures, differential expression and known AML-related genes. Taken together, our results support the notion that transcriptome assessment could be used as part of an integrated genomic approach in cancer diagnosis and treatment to be implemented early on for diagnosis and differential diagnosis of AML. One Sentence Summary Blood gene expression data and machine learning were used to develop robust and accurate classifiers for diagnosis and differential diagnosis of acute myeloid leukemia based on analysis of more than 12,000 samples derived from more than 100 individual studies
The Impact of Hydraulic Retention Time on the Biomethane Production from Palm Oil Mill Effluent (POME) in Two-Stage Anaerobic Fluidized Bed Reactor

Indonesia is currently the most significant crude palm oil (CPO) producer in the world. In the production of CPO , 0.7 m 3 of Palm Oil Mill Effluent (POME ) is emitted as the wastewater for every ton of fresh fruit bunches processed in the palm oil mill . With the increasing amount of CPO production , an effective POME treatment system is urgently required to prevent severe environmental damage. The high organic content in the POME is a potential substrate for bio-methane production. The biomethane production is carried out by two groups of microbes, i.e., acidogenic and methanogenic microbes. Each group of bacteria performs optimally at different optimum conditions. To optimize the biomethane production, POME was treated sequentially by separating the acidogenic and methanogenic microbes into two stages of anaerobic fluidized bed reactor s ( AFBR ) . The steps were optimized differently according to the favorable conditions of each group of bacteria . Although perfect separation cannot be achieved, this study showed that pH control could split the domination of the bacteria, i.e., the first stage (maintained at pH 4-5) was dominated by the acidogenic microbes and the second stage (kept neutral) was governed by methanogens. In addition to the pH control, n atural zeolite was added as microbial immobilization media in the AFBR to improve the performance of the microorganisms, especially in preventing microbial wash out at short hydraulic retention time (HRT) . This study was focused on the understanding of the effect of HRT on the performance of steady-state continuous AFBR. T he first stage as the acidogenic reactor was run under acidic conditions (pH 4-5) at five different HRTs . In comparison, the second stage as the methanogenic reactor was run under the neutral condition at four different HRTs. In this work , short HRT (5 days) resulted in better performance in both acidogenic AFBR and methanogenic AFBR. The immobilization media was hence essential to reduce the risk of washout at such a short HRT. The two- stage system also resulted in quite a high percentage of soluble chemical oxygen demand ( sCOD ) removal, which was as much as 96.06% sCOD .
Quality Evaluation of Beef Sausage Formulated with Different Levels of Dried Pumpkin Powder

The present study aim at investigating the quality properties of beef sausage formulated with dried pumpkin powder. Sausages prepared with recommended raw materials. Three levels of dried pumpkin powder (10%, 20%, and 30%) incorporated, while control sample left free (0%). Proximate composition, pH value, water holding capacity, microbiological aspects and sensory properties of beef sausages were carried out. Incorporation of dried pumpkin powder had significant impact, where decreasing pattern of moisture content observed as the level of dried pumpkin powder increased. The sample formulated with 30% dried pumpkin powder recorded the lowest moisture content (64.22%) compared with (72.43%) for the control sample. Significance increase (p ) of fat and protein content recorded, where the sample formulated with 30% dried pumpkin powder recorded the highest content (9.30%) and (20.55%), respectively. Moreover, increase of dried pumpkin powder levels decreased pH value and increased water holding capacity. Produced sausage samples had total viable bacterial count ranged between 2.89 log 10 cfu/g and 1.70 log 10 cfu/g. Interestingly, the findings obtained mirrored that all samples free of salmonella. Positive effect on improvement of color observed where, the sample formulated with 30% recorded the highest score rating (5.38) compared with the control sample (4.90).
The role of myocardial perfusion imaging in the identification of the obstructive coronary artery lesions: a tertiary cardiology center experience

Objectives: Because of the moderate accuracy of treadmill electrocardiogram and fear of a claim if a diagnosis is missed, cardiologists usually order Myocardial Perfusion Imaging (MPI) as a first-step test in most of patients with chest pain admitted to cardiology department. The performance of the MPI in diagnosing obstructive CAD depends on the population studied. Thus we aimed to assess the agreement between MPI and coronary angiography in the identification of the obstructive coronary lesion. Methods: A total of 231 patients who underwent MPI due to suspicion of coronary ischemia and had a coronary angiogram within the last three months were included in this retrospective study. MPI and coronary angiography findings were analyzed to weigh the performance of MPI in determining obstructive coronary lesion. Results: The mean age was 63.9 ± 8.9 years, 54.5% being males. MPI showed a sensitivity of 0.86 in determining patients who had a significant (> 70%) coronary lesion. While evaluating the ability of MPI to detect ischemia in the left ventricle region which is supplied by the lesioned vessel, the sensitivity was found to be; 60% in determining anterior ischemia associated with significant LAD lesion, 77.4% in determining inferior ischemia associated with significant RCA lesion, and 44.4% in determining lateral ischemia associated with significant CX lesion. Conclusions: Our findings have shown that MPI with visual assessment has 86% sensitivity for detecting significant coronary artery stenosis. However, the sensitivity of MPI in determining ischemia in the left ventricle region which is supplied by the lesioned coronary artery was found to be 44.4 to 77.4%.
Studies on Mutagenic Efficiency and Effectiveness of Sodium Azide on Indian mustard in M2 Generation

Rapeseed-Mustard are important oilseed crop of the world being grown in around 50 countries across the six continents. The crop is grown both in sub-tropical and tropical countries. Among different oilseed crops grown in India, the Rapeseed-Mustard (Brassica spp.) contributes 29.5% in the total production of oilseeds. In India, it is the second most important edible oilseed after groundnut sharing 27.8% in the India’s oilseed economy (Anonymous, 2015). Indian mustard, Brassica juncea (L.) Czern and Coss (2n = 2x = 36, genome AABB) is the oldest of the cultivated amphidiploids. It is called as “rai”, “raya” or “laha” is one of the important oilseed crops belonging to family cruciferae (Syn. Brassicaceae) and genus Brassica. The available evidences indicate that B.juncea was under cultivation in Indus valley in around 3000 BC. The species probably evolved in the Middle East, where its putative diploid progenitors Brassica rapa and Brassica nigra are sympatric (Prakash and Hinata, 1980). Mustard is largely self-pollinated crop but certain amount (5 18%) of cross pollination may take place (Labana and Banga, 1984).
A Qualitative Evaluation of The Nelson Trust Griffin Programme

This report outlines the findings of a qualitative evaluation which explores the impact of a trauma-specific programme. The Griffin programme, is an evidenced-based intervention to support healing and recovery for women with sex-working histories, within residential recovery. The findings highlighted the specialist nature of the programme and the importance of prioritising love within healing, recovery and rehabilitation.
Effects of timing of food intake and fat/carbohydrate ratio on insulin sensitivity and preconditioning against renal ischemia reperfusion injury by calorie restriction

BACKGROUND: Dietary restriction (DR) improves lifespan, metabolic fitness and resilience in many organisms, but the role of dietary macronutrient composition and timing of food intake in specific benefits remains unclear. OBJECTIVE: We sought to compare the effects of two isocaloric DR regimes differing in the timing of food intake - every other day (EOD) fasting/feeding vs. daily calorie restriction (CR) – at two different fat/carbohydrate ratios on two well-established DR benefits, improved glucose homeostasis and protection from renal ischemia reperfusion injury in mice. We hypothesized that both EOD fasting and isocaloric CR would result in similar improvements in glucose homeostasis and stress resistance independent of macronutrient composition. METHODS: Six groups of mice were fed either semi-purified low-fat diet (LFD, 10% calories from fat) or high-fat diet (HFD, 60% calories from fat) and randomized into one of three dietary regimens: 1) ad libitum (AL), 2) EOD feeding/fasting, or 3) pair-fed daily to the average daily EOD intake within LFD or HFD feeding group resulting in daily CR. After 6 weeks, the following assessments were made: fasting blood glucose, glucose and insulin tolerance, and resistance to bilateral renal ischemia reperfusion injury using serum urea as a marker of renal function. Within the EOD group, the effects of prior day feeding (EODfed vs. EODfast) were also assessed. RESULTS: EOD mice ate ∼20–25% less food over time than AL mice on the corresponding LFD or HFD. EOD and CR mice displayed changes in body weight, fasting blood glucose levels and glucose tolerance commensurate with total calorie intake. No significant differences were observed in circulating IGF-1 levels. Insulin sensitivity improved independent of fat/carbohydrate ratio on daily CR and EODfast regimens, but not EODfed. HFD increased susceptibility to renal ischemia reperfusion in AL mice, while CR and EOD regimens gave significant protection independent of dietary fat content or fed or fasted day in the EOD group. CONCLUSIONS: Reduced food intake protects mice against renal ischemia reperfusion injury within 6 weeks independent of timing of food intake (CR, EODfast, EODfed) or fat content of diet (10% vs. 60%). Neither circulating IGF-1 levels (unchanged) nor whole-body insulin sensitivity (improved upon daily CR and EODfast but not EODfed) correlated with protection, so are unlikely to be involved mechanistically.
The Effects Of Mudharabah And Musyarakah Financing On The Profitability Of Sharia Commercial Banks In Indonesia

: This research was conducted to determine the effect of mudharabah and musharakah profit sharing financing on the profitability of Islamic commercial banks in Indonesia. This study uses the annual Islamic Commercial Bank financial reports obtained from the Financial Services Authority (Otoritas Jasa Keuangan) for the period 2015-2019. The test results using SPSS 25 show that both mudharabah and musyarakah financing have a significant effect on the profitability of Islamic banks. But unlike musyarakah financing, mudharabah financing actually has a negative effect on profitability, meaning that the higher an Islamic bank distributes mudharabah financing, the rate of profit will decrease.
The integration of visual and target signals in V4 and IT during visual object search

Many everyday tasks require us to flexibly map incoming sensory information onto behavioral responses based on context. One example is the act of searching for a specific object, which requires our brain to compare the items in view with a remembered representation of a sought target to determine whether a target match is present. During object search, this comparison is thought to be implemented, in part, via the combination of top-down modulations reflecting target identity with feed-forward visual representations. However, it remains unclear whether these top-down signals are integrated at a single locus within the ventral visual pathway (e.g. V4) or at multiple stages (e.g. both V4 and inferotemporal cortex, IT). To investigate, we compared neural responses in V4 and IT recorded as rhesus monkeys performed a task that required them to identify when a target object appeared across variation in position, size and background context. We found non-visual, task-specific signals in both V4 and IT. To evaluate the plausibility that V4 was the only locus for the integration of top-down signals, we evaluated a number of feed-forward accounts of processing from V4 to IT, including a model in which IT preferentially sampled from the best V4 units, as well as a model that allowed for nonlinear IT computation. IT task-specific modulation could not be accounted for by any of these feed-forward descriptions, suggesting that during object search, top-down signals are integrated directly within IT itself. SIGNIFICANCE To find specific objects, the brain must combine top-down information reflecting the identity of a sought target with visual information about objects in view. While top-down signals exist at multiple stages along the ventral visual pathway, the route with which they arrive there is unclear. Here we present evidence that task-relevant signals in one high-level visual brain area, IT, cannot be described as being inherited from an earlier stage of processing, V4, but rather must be integrated directly within IT itself. This study is the first to systematically compare V4 and IT during an object search task in which objects can appear in different real-world configurations, and it provides important constraints on the neural computations responsible for finding visual targets.