Miracle-dz/UniFAR-FTUs huggingface dataset:
Epigallocatechin-3-Gallate (EGCG), An Active Constituent of Green Tea: Implications in the Prevention of Liver Injury Induced by Diethylnitrosamine (DEN) in Rats

Liver diseases are one of the most detrimental conditions that may cause inflammation, leading to tissue damage and perturbations in functions. Several drugs are conventionally available for the treatment of such diseases, but the emergence of resistance and drug-induced liver injury remains pervasive. Hence, alternative therapeutic strategies have to be looked upon. Epigallocatechin-3-gallate (EGCG) is a naturally occurring polyphenol in green tea that has been known for its disease-curing properties. In this study, we aimed to evaluate its anti-oxidative potential and protective role against diethylnitrosamine (DEN)-induced liver injury. Four different groups of rats were used for this study. The first group received normal saline and served as the control group. The second group received DEN (50 mg/kg body wt) alone and third group received DEN plus EGCG (40 mg/kg body wt) only. The fourth group were treated with EGCG only. The liver protective effect of EGCG against DEN toxicity through monitoring the alterations in aspartate transaminase (AST), and alanine transaminase (ALT) and alkaline phosphatase (ALP) activities, serum level of pro-inflammatory mediators and anti-oxidant enzymes, histopathological alterations, measurement of cellular apoptosis, and cell cycle analysis was examined. The rats that were given DEN only had a highly significantly elevated levels of liver enzymes and pro-inflammatory cytokines, highly decreased anti-oxidative enzymes, and histological changes. In addition, a significant elevation in the percentage of apoptotic nuclei and cell cycle arrest in the sub- G1 phase was detected. EGCG acts as a hepatoprotectant on DENs by reducing the serum levels of liver functional enzymes, increasing total anti-oxidative capacity, reducing pathological changes and apoptosis, as well as causing the movement of cells from the sub G1 to S or G2/M phase of the cell cycle. In conclusion, EGCG displayed a powerful hepatoprotective additive as it considerably mitigates the liver toxicity and apoptosis induced by DEN.
Multiple Hydrogen-Bonding Assisted Scratch–Healing of Transparent Coatings

The partial cross-linking reaction of poly(vinyl alcohol) (PVA) by esterification using poly(acrylic acid) (PAA) as a cross-linking agent was performed to obtain a PVA–PAA supramolecular polymer complex. The PVA–PAA coatings with a different molar ratio between hydroxyl and carboxyl groups were prepared to examine scratch–healing ability. These coatings exhibited high optical transparency and excellent scratch–healing properties, which are attributed to considerable amount of free hydroxyl groups at the scratched interfaces to reversibly form multiple hydrogen bonds. Importantly, the PVA–PAA polymer was capable of initiating scratch recovery at temperature of 20 °C and relative humidity (RH) of 40%. Scratches produced on the PVA–PAA polymer coatings with different constant loading in the range of 1.5–2.7 N were healed significantly more rapidly under humid conditions (RH = 99%). Increase of cross-linking temperature also resulted in similar effect but with some reduction of the final scratch healing ratio.
CORPORATE GOVERNANCE, RISK-TAKING AND FIRM PERFORMANCE OF ISLAMIC BANKS DURING GLOBAL FINANCIAL CRISIS

Manuscript Type: Empirical Research Question/Issue: The global banking system virtually halted during the recent global financial crisis, but Islamic Banks were not as exposed as much. We examine if a multi-layer governance structure laced with Islamic ethical banking principles was responsible for preventing Islamic banks to fail during the 2007-2009 financial crisis. Research Findings/Insights: Using a paired-sample of 84 Islamic and conventional banks from Bangladesh, Bahrain, Malaysia Pakistan, Saudi Arabia, the United Arab Emirates, and the United Kingdom over the period of 2006-2009, we find that the corporate governance and financial disclosure indices emerged as the key driving forces for risk-taking for Islamic banks. Theoretical/Academic Implications: This research contributes to the multi-layer corporate governance model that is based on moral values as practiced in Islamic banks can be an effective governance mechanism in minimizing future financial crises. Practitioner/Policy Implications: Our findings cast doubt on the independence of Shari’ah Boards. Multiple board positions limit their ability to function as effective monitors as well as Islamic value proposition quality controllers.
The economic cost of air pollution: Evidence from Europe

This study provides the first evidence that air pollution causes economy-wide reductions in market economic activity based on data for Europe. The analysis combines satellite-based measures of air pollution with statistics on regional economic activity at the NUTS-3 level throughout the European Union over the period 2000-15. An instrumental variables approach based on thermal inversions is used to identify the causal impact of air pollution on economic activity. The estimates show that a 1μg/m3 increase in PM2.5 concentration (or a 10% increase at the sample mean) causes a 0.8% reduction in real GDP that same year. Ninety-five per cent of this impact is due to reductions in output per worker, which can occur through greater absenteeism at work or reduced labour productivity. Therefore, the results suggest that public policies to reduce air pollution may contribute positively to economic growth. Indeed, the large economic benefits from pollution reduction uncovered in the study compare with relatively small abatement costs. Thus, more stringent air quality regulations could be warranted based solely on economic grounds, even ignoring the large benefits in terms of avoided mortality.
The Tax Structure of an Economy in Crisis: Greece 2009-2017

The 2010 Economic Adjustment Programme initiated a period of strict international supervision with respect to tax policy in Greece. The country implemented a large-scale fiscal consolidation package, aiming to reduce its public deficit below 3% of GDP by 2016. Since the beginning of the crisis, the provisions of the ‘Greek Programme’ have been revised several times, and personal income tax reform has figured prominently on almost each of the revision agendas. This paper aims to provide an assessment of the effects of the four major structural reforms that took place in Greece during and in the aftermath of the economic crisis; using microsimulation techniques, we simulate the (ceteris paribus) first-order impact of these reforms on the distribution of incomes, the state budget and work incentives, while also trying to identify the main gainers and losers of these policy changes. Our results suggest that all reforms had a revenue-increasing rationale, with the one of 2011 being designed to have the largest fiscal gains. The latter also strengthened redistribution and achieved the highest decrease in income inequality. The 2013 reform went to the opposite direction by reducing both the redistributive strength and the progressive nature of the Greek tax system. The striking discrepancies in the ways in which different household categories have been affected by the four reforms call for a deeper investigation of the possibility of moving towards more uniform personal income tax rules.
Meteorological factors associated with hand, foot and mouth disease in a Central Highlands province in Viet Nam: an ecological study

Background Hand, foot and mouth disease (HFMD) is a public health problem in Viet Nam, and studies have reported seasonal fluctuation in the occurrence of HFMD. This study sought to describe the occurrence of HFMD and its associated meteorological factors in Dak Lak province, Viet Nam. Methods Monthly data on HFMD cases were collected from all commune health stations in Dak Lak province from 2012 through 2013. An HFMD case was defined as a brief febrile illness accompanied by a typical skin rash with or without mouth ulcers. Average temperature, maximum temperature, minimum temperature, humidity, rainfall, evaporation, sunshine duration and wind speed were recorded monthly at five local meteorological stations throughout Dak Lak.Data were aggregated at the district level, and the association between these meteorological factors and HFMD cases were examined by Poisson regression. Results In 2012 through 2013, there were 7128 HFMD patients in Dak Lak. The number of HFMD cases increased during the rainy season. An increased risk of HFMD was associated with higher average temperature (risk ratio and 95% confidence interval: 1.06; 1.03–1.08 per 1 °C increase), higher rainfall (1.19; 1.14–1.24 per 200 mm increase) and longer sunshine duration (1.14; 1.07–1.22 per 60 hours increase). The risk of HFMD was inversely associated with wind speed (0.77; 0.73–0.81 per 1 m/s increase). Conclusion This study suggests that there is a significant association between HFMD occurrence and climate. Temperature, rainfall, wind speed and sunshine duration could be used as meteorological predictors of HFMD occurrence in Viet Nam’s Central Highlands region. Intensified surveillance for HFMD during the rainy season is recommended.
Diversified Arable Cropping Systems and Management Schemes in Selected European Regions Have Positive Effects on Soil Organic Carbon Content

In the last few decades, various crop diversification strategies and management practices have been promoted to improve or at least maintain environmental quality and agroecosystem services. We conducted a data-analysis to evaluate the effectiveness of alternatives for crop diversification and environmentally friendly farming management for arable crops in four selected European pedoclimatic regions and typical cropping systems in the Atlantic, Boreal, Mediterranean North, and Mediterranean South regions. The dataset was retrieved from 38 references and included data on site-specific environmental conditions, soil tillage, crop rotation, fertilization, and final soil organic carbon content (SOC). No tillage (NT) was more effective (7%) in increasing SOC content than minimum tillage (MT) across the studied depths (from 5 to 40 cm). Conservation tillage as whole, including NT, MT, and rotational tillage (RT) positively affected SOC content in the top 10 cm (28%) in comparison with conventional tillage (CT). Compared to monoculture, longer crop rotations (3–5 years) and the introduction of legumes resulted in higher increases in SOC contents (18%), that were higher in semiarid conditions (11%) than under humid and sub-humid climates (3.2%). The effect of fertilization on SOC contents was higher in the Mediterranean North region (28%), and organic fertilization showed the highest increases (25%) compared to the control with mineral fertilization. Higher increases in SOC contents with tillage and fertilization management were found in sites with lower SOC contents in the control treatment (conventional tillage and mineral fertilization respectively). The data analysis indicated that various European arable agroecosystems benefit both from diversified cropping systems and the adoption of environmentally friendly farming management and are thereby capable to increase SOC contents.
Innovation and growth in the UK pharmaceuticals: the case of product and marketing introductions1

New drug introductions are a key to growth for pharmaceutical firms. However not all innovations are the same and they may have differential effects that vary by firm size. We use quarterly sales data on UK pharmaceuticals in a dynamic panel model to estimate the impact of product (new drugs) and marketing (additional pack varieties) innovations within a therapeutic class on a firm’s business unit growth. We find that product innovations lead to substantial growth in both the short and long run, whereas a new pack variety only produces short-term effects. The strategies are substitutes but the marginal effects are larger for product innovations relative to additional packs, and the effects are larger for smaller business units. Nonetheless, pack introductions offer a viable short-term growth strategy, especially for small and medium sized businesses.
Further Studies on Bacterium Necrophorum Isolated from Cases of Chronic Ulcerative Colitis

Bacterium necrophorum has been found in a large number of pathological conditions in nearly all domestic animals and in some wild animals. In man it has been reported in only a few isolated cases. Our experience, in reviewing the literature and in searching for this organism in ulcerated colons in man, has indicated that Bact. necrophorum is perhaps as common in man as in other animals. The French workers' have ascribed to Bacillus funduliformis the cause of many pathological conditions in man which resemble Bact. necrophorum infections in animals. Recently Henthorne, Thompson and Beaver2 of the Mayo Clinic described the isolation of the funduliformis organism in pure culture from four cases of hepatic abscess. Three of the patients had carcinoma of the rectum and in the fourth the primary pathological lesion was unknown. They also isolated this organism in pure culture from a fecal (? ) fistula in a patient with a carcinoma of the sigmoid flexure. A sixth culture they isolated in mixture with other organisms from a pulmonary abscess. A careful survey of the literature fails to reveal any striking difference between Bact. necrophorum and the funduliformis organism. The present paper deals with (1) the isolation of Bact. necrophorum from additional cases of chronic ulcerative colitis, (2) a study of the biochemical properties of the strains, (3) the morphology of Bact. necrophorum on blood agar to which cevitamic acid has been added, (4) pathogenicity and immunity studies in rabbits, (5) attempts to ulcerate the normal isolated colon of a rhesus monkey with Bact. necrophorum, and (6) the effect of repeated curettage of the colon in two sphinx baboons.
Development of a Novel Psycho-biological Tool for the Measurement of Oral Mucositis in Head and Neck Cancer Patients Undergoing Radiotherapy and Concomitant Chemotherapy

Objective: Evaluate a patient-reported-oral mucositis scale (PROMS) on its own and in relation to existing measures of mucositis. Methods: 50 patients with head and neck cancer receiving radiotherapy were examined before cancer treatment, twice weekly during 6-7 weeks of therapy and post-therapy. Oral mucositis (OM) signs were evaluated clinically using NCI-CTCAE v.3, OMAS criteria and Total VAS-OMAS score. OM symptoms were recorded on PROMS-VAS questionnaires. Albumin and polymorphonuclear neutrophils were measured in saline rinses. The PROMS data were subjected to Spearman rank correlations versus the other clinical and biomarker data. Results: 33 participants completed the study. Significant correlations (p<.001) were seen between PROMS scores and other clinical and biomarker indicators of OM at a group level. Significant variations were seen between individuals. Conclusion: The PROMS tool demonstrates good correlation with other clinical indicators of OM and adds novel dimensions to currently available methods of assessments used for quantification of OM.
Evaluation of Social Appearance Anxiety and Quality of Life in Patients with Acne Vulgaris

Bulgular: Akne vulgarisli hastalarda SGKÖ değeri kontrol grubundan anlamlı olarak daha yüksekti (p<0.05). Akneli kadın ve erkek hastalar arasında GADS dağılımı, GAS değeri, anksiyete varlığı, HAD (depresyon) puanları arasında farklılık gözlenmedi (p>0.05). Kadın hastalarda AYKÖ ve SGKÖ puanı erkeklerden daha yüksekti (p<0.05). Ayrıca kadın hastalarda depresyon ve anksiyete (HADÖ) puanları erkeklerden daha yüksek olarak bulundu (p<0.05). Akne vulgarisi şiddetli olan hastaların hafif şiddetli aknelilere göre yaşam kalitesi daha fazla bozulmuştu (p<0.05). Akne şiddeti ile anksiyete depresyon, sosyal görünüş kaygısı arasında ilişki saptanmadı.
Probing black hole accretion tracks, scaling relations, and radiative efficiencies from stacked X-ray active galactic nuclei

The masses of supermassive black holes at the centres of local galaxies appear to be tightly correlated with the mass and velocity dispersions of their galactic hosts. However, the local Mbh–Mstar relation inferred from dynamically measured inactive black holes is up to an order-of-magnitude higher than some estimates from active black holes, and recent work suggests that this discrepancy arises from selection bias on the sample of dynamical black hole mass measurements. In this work, we combine X-ray measurements of the mean black hole accretion luminosity as a function of stellar mass and redshift with empirical models of galaxy stellar mass growth, integrating over time to predict the evolving Mbh–Mstar relation. The implied relation is nearly independent of redshift, indicating that stellar and black hole masses grow, on average, at similar rates. Matching the de-biased local Mbh–Mstar relation requires a mean radiative efficiency ε ≳ 0.15, in line with theoretical expectations for accretion on to spinning black holes. However, matching the ‘raw’ observed relation for inactive black holes requires ε ∼ 0.02, far below theoretical expectations. This result provides independent evidence for selection bias in dynamically estimated black hole masses, a conclusion that is robust to uncertainties in bolometric corrections, obscured active black hole fractions, and kinetic accretion efficiency. For our fiducial assumptions, they favour moderate-to-rapid spins of typical supermassive black holes, to achieve ε ∼ 0.12–0.20. Our approach has similarities to the classic Soltan analysis, but by using galaxy-based data instead of integrated quantities we are able to focus on regimes where observational uncertainties are minimized.
A Gap Analysis of Low-Cost Outdoor Air Quality Sensor In-Field Calibration

In recent years, interest in monitoring air quality has been growing. Traditional environmental monitoring stations are very expensive, both to acquire and to maintain, therefore their deployment is generally very sparse. This is a problem when trying to generate air quality maps with a fine spatial resolution. Given the general interest in air quality monitoring, low-cost air quality sensors have become an active area of research and development. Low-cost air quality sensors can be deployed at a finer level of granularity than traditional monitoring stations. Furthermore, they can be portable and mobile. Low-cost air quality sensors, however, present some challenges: they suffer from crosssensitivities between different ambient pollutants; they can be affected by external factors such as traffic, weather changes, and human behavior; and their accuracy degrades over time. Some promising machine learning approaches can help us obtain highly accurate measurements with low-cost air quality sensors. In this article, we present low-cost sensor technologies, and we survey and assess machine learning-based calibration techniques for their calibration. We conclude by presenting open questions and directions for future research.
Generalised effective cosmology from group field theory

We extend various recent results regarding the derivation of effective cosmological Friedmann equations from the dynamics of group field theory (GFT). Restricting ourselves to a single GFT field mode (or fixed values of Peter–Weyl representation labels), we first consider dynamics given by a quadratic Hamiltonian, which takes the form of a squeezing operator, and then add a quartic interaction that can be seen as a toy model for interactions in full GFT. Our derivation of effective Friedmann equations does not require a mean-field approximation; we mostly follow a general approach in which these equations in fact hold for any state. The resulting cosmological equations exhibit corrections to classical Friedmann dynamics similar to those of loop quantum cosmology, leading to generic singularity resolution, but also involve further state-dependent terms. We then specify these equations to various types of coherent states, such as Fock coherent states or Perelomov–Gilmore states based on the su(1, 1) structure of harmonic quantum cosmology. We compute relative uncertainties of volume and energy in these states, clarifying whether they can be interpreted as semiclassical. In the interacting case, both analytical and numerical approximations are used to obtain modified cosmological dynamics. Our results clarify how effective cosmological equations derived from GFT can provide reliable approximations to the full dynamics.
Fast downflows in a chromospheric filament

Abstract An active region filament in the upper chromosphere is studied using spectropolarimetric data in He i 10830 Å from the GREGOR telescope. A Milne-Eddingon based inversion of the Unno-Rachkovsky equations is used to retrieve the velocity and the magnetic field vector of the region. The plasma velocity reaches supersonic values closer to the feet of the filament barbs and coexist with a slow velocity component. Such supersonic velocities result from the acceleration of the plasma as it drains from the filament spine through the barbs. The line-of-sight magnetic fields have strengths below 200 G in the filament spine and in the filament barbs where fast downflows are located, their strengths range between 100 - 700 G.
End-to-End Learning of Visual Representations From Uncurated Instructional Videos

Annotating videos is cumbersome, expensive and not scalable. Yet, many strong video models still rely on manually annotated data. With the recent introduction of the HowTo100M dataset, narrated videos now offer the possibility of learning video representations without manual supervision. In this work we propose a new learning approach, MIL-NCE, capable of addressing mis- alignments inherent in narrated videos. With this approach we are able to learn strong video representations from scratch, without the need for any manual annotation. We evaluate our representations on a wide range of four downstream tasks over eight datasets: action recognition (HMDB-51, UCF-101, Kinetics-700), text-to- video retrieval (YouCook2, MSR-VTT), action localization (YouTube-8M Segments, CrossTask) and action segmentation (COIN). Our method outperforms all published self-supervised approaches for these tasks as well as several fully supervised baselines.
Colored unavoidable patterns and balanceable graphs

We study a Turan-type problem on edge-colored complete graphs. We show that for any $r$ and $t$, any sufficiently large $r$-edge-colored complete graph on $n$ vertices with $\Omega(n^{2-\frac{1}{t}})$ edges in each color contains an $(r,t)$-unavoidable graph, where an $(r,t)$-unavoidable graph is essentially a $t$-blow-up of an $r$-colored complete graph where all $r$ colors are present. The result is tight up to the implied constant factor, assuming the well-known conjecture that $ex(K_{t,t})=\Theta(n^{2-{1/t}})$. Next, we study a related problem where the corresponding Turan threshold is linear. In particular, we show that any $3$-edge-coloring of a large enough complete graph with $kn+o(n)$ edges in each color contains a path on $3k$ edges with an equal number of edges from each color. This is tight up to a constant factor of $2$.