Miracle-dz/UniFAR-FTUs huggingface dataset:
Handedness and the 2016 U.S. Primaries: consistent handedness predicts support for Donald Trump among republicans, but gender predicts support for Hillary Clinton among democrats

ABSTRACT A growing number of studies demonstrate that consistent handers, people who use their dominant hand for all or most manual tasks, are less cognitively flexible than inconsistent handers, people who use their non-dominant hands at least some of the time. A recent hypothesis suggests that differences in handedness emerged evolutionarily because populations benefited from a balance between cognitively rigid and cognitively flexible people. One expectation is that cognitively rigid consistent handers would support more authoritarian policies or candidates. To test this idea, we looked at handedness, gender, and political affiliation as predictors of support for Donald Trump, a candidate whose supporters self-report being more authoritarian, in the 2016 primary. Our data show that in the Republican Primary, consistent handers report more support than inconsistent for Donald Trump. When authoritarianism was added as a covariate, the handedness effect disappeared. Further analyses showed that authoritarianism mediates the relationship between handedness and support for Donald Trump. In the Democratic Primary, there was a main effect of gender. Women reported more support than men for Hillary Clinton.
Restricted feeding could enhance feed conversion ratio and egg quality of laying Japanese quail kept under different stocking densities

Abstract Impacts of different stocking densities and feed restriction on egg production and quality and blood biochemicals of laying Japanese quail (Coturnix coturnix Japonica) were studied. A total number of 360 adult Japanese quails were used in an experiment, including two stocking densities (300 and 200 cm2/bird) and four feed restriction levels (ad libitum, 25, 30 and 35 g/day/bird). As a result of this study, feed restriction (30 g/bird/day) enhanced most of egg production traits and improved hatchability. Albumen and egg shell thickness showed the highest values when birds fed ad libitum and 35 g/bird/day. Blood total protein, albumin, Aspartate Aminotransferase (AST) and cholesterol were higher in quails housed at 200 cm2/bird than those kept at 300 cm2/bird. The highest values of blood total protein, albumin, AST and cholesterol were found in quails fed ad libitum. Activity of superoxide dismutase was the highest estimate when birds stocked at 300 cm2/bird and fed ad libitum or 25 g/day. Conclusively, decreasing space per bird had a negative effect on performance. Feed restriction can achieve a better feed conversion ratio (FCR).
Cost‐effectiveness analysis of cytomegalovirus prophylaxis in allogeneic hematopoietic cell transplant recipients from a US payer perspective

To evaluate the cost‐effectiveness of letermovir versus no prophylaxis for the prevention of cytomegalovirus infection and disease in adult cytomegalovirus‐seropositive allogeneic hematopoietic cell transplantation (allo‐HCT) recipients. A decision model for 100 patients was developed to estimate the probabilities of cytomegalovirus infection, cytomegalovirus disease, various other complications, and death in patients receiving letermovir versus no prophylaxis. The probabilities of clinical outcomes were based on the pivotal phase 3 trial of letermovir use for cytomegalovirus prophylaxis versus placebo in adult cytomegalovirus‐seropositive recipients of an allo‐HCT. Costs of prophylaxis with letermovir and of each clinical outcome were derived from published sources or the trial clinical study reports. Incremental cost‐effectiveness ratios (ICERs) in terms of cost per quality‐adjusted life year (QALY) gained were used in the model. One‐way and probabilistic sensitivity analyses were conducted to explore uncertainty around the base‐case analysis. In this model, the use of letermovir prophylaxis would lead to an increase of QALYs (619) and direct medical cost ($1 733 794) compared with no prophylaxis (578 QALYs; $710 300) in cytomegalovirus‐seropositive recipients of an allo‐HCT. Letermovir use for cytomegalovirus prophylaxis was a cost‐effective option versus no prophylaxis with base‐case analysis ICER $25 046/QALY gained. One‐way sensitivity analysis showed the most influential parameter was mortality rate. The probabilistic sensitivity analysis showed a 92% probability of letermovir producing an ICER below the commonly accepted willingness‐to‐pay threshold of $100 000/QALY gained. Based on this model, letermovir use for cytomegalovirus prophylaxis was a cost‐effective option in adult cytomegalovirus‐seropositive recipients of an allo‐HCT.
Animal Mitochondrial DNA Recombination

Animal mitochondrial DNA as a genetic marker has been used extensively in many biological fields from intraspecific to higher taxonomic categories.Most of these applications are based on the properties of strict maternal inheritance and non-recombination of mtDNA.Recent studies have provided some indirect and direct evidence of animal mtDNA recombination.Animal mtDNA recombination might occur by two main pathways,recombination between the maternal mtDNA and a nuclear encoded pseudogene copy of mtDNA and the combination between paternal and maternal mtDNA haplotypes through paternal leakage.Paternal leakage appears to be the most plausible pathway of mtDNA recombination.If animal mtDNA recombination occurs commonly in animal kindom,it will have significant influences to many application areas based on strict maternal inheritance.
Kinetics of cytomegalovirus and Epstein-Barr virus DNA in whole blood and plasma of kidney transplant recipients: Implications on management strategies

This retrospective multicenter cohort study investigated the kinetics (ascending and descending phases) of cytomegalovirus (CMV) and Epstein-Barr virus (EBV)-DNA in whole blood (WB) and plasma samples collected from adult kidney transplant (KT) recipients. CMV-DNA kinetics according to antiviral therapy were investigated. Three hundred twenty-eight paired samples from 42 episodes of CMV infection and 157 paired samples from 26 episodes of EBV infection were analyzed by a single commercial molecular method approved by regulatory agencies for both matrices. CMV-DNAemia followed different kinetics in WB and plasma. In the descending phase of infection, a slower decay of viral load and a higher percentage of CMV-DNA positive samples were observed in plasma versus WB. In the 72.4% of patients receiving antiviral therapy, monitoring with plasma CMV-DNAemia versus WB CMV-DNAemia could delay treatment interruption by 7–14 days. Discontinuation of therapy based on WB monitoring did not result in relapsed infection in any patients. Highly different EBV-DNA kinetics in WB and plasma were observed due to lower positivity in plasma; EBV positive samples with a quantitative result in both blood compartments were observed in only 11.5% of cases. Our results emphasize the potential role of WB as specimen type for post-KT surveillance of both infections for disease prevention and management.
Blood pressure control in patients with chronic kidney disease according to office and home blood pressures

Objectives The aim of this study was to assess blood pressure (BP) control in patients with chronic kidney disease (CKD) according to office and home BP and to assess the prevalence of normal BP, white-coat uncontrolled hypertension (WUCH), masked uncontrolled hypertension (MUCH) and elevated BP. Methods Patients with renal failure with or without proteinuria were included in this multicenter observational study. Office BP was first measured by the physician using a self-monitoring BP device (three automatic readings), then by the patient at home (morning and evening) over 3 consecutive days. WUCH was defined as a systolic BP (SBP)/diastolic BP (DBP) ≥140/90 mmHg in the clinic and SBP/DBP<135/85 mmHg at home. MUCH was defined as SBP/DBP <140/90 mmHg in the clinic and SBP/DBP ≥135/85 mmHg at home. Results Among the 243 included subjects, data of 225 patients were analyzed. Mean estimated glomerular filtration rate was 37.7 ± 15.7 mL/min/1.73 m2 and mean office SBP/DBP was 154 ± 19/83 ± 13 mmHg. Mean office SBP/DBP was significantly higher than home SBP/DBP (+9.0 ± 15.1/+7.0 ± 10.0 mmHg, P < 0.01). Normal BP (office and home BP), WUCH, MUCH and elevated BP (office and home BP) rates were 12.0, 14.2, 6.7 and 67.1%, respectively. The patients were taking, on average, 2.8 ± 1.5 antihypertensive drugs/day. Conclusion BP control in patients with CKD was poor. Routine use of ‘out-of-office’ BP measurement, in addition to office BP by which we can identify patients with WUCH or MUCH, should be recommended based on the current findings.
High Levels of Anabaenopeptins Detected in a Cyanobacteria Bloom from N.E. Spanish Sau-Susqueda-El Pasteral Reservoirs System by LC–HRMS

The appearance of a bloom of cyanobacteria in the Sau-Susqueda-El Pasteral system (River Ter, NE Spain) in the autumn of 2015 has been the most recent episode of extensive bloom detected in Catalonia. This system is devoted mainly to urban supply, regulation of the river, irrigation and production of hydroelectric energy. In fact, it is one of the main supply systems for the metropolitan area of cities such as Barcelona and Girona. An assessment and management plan was implemented in order to minimize the risk associated to cyanobacteria. The reservoir was confined and periodic sampling was carried out. Low and high toxicity was detected by cell bioassays with human cell lines. Additionally, analysis studies were performed by enzyme-linked immunosorbent assay (ELISA) and liquid chromatography–high resolution mass spectrometry (LC–HRMS). A microcystin target analysis and suspect screening of microcystins, nodularins, cylindrosperpmopsin and related cyanobacterial peptides by LC–HRMS were applied. The results for the analysis of microcystins were negative (<0.3 μg/L) in all the surface samples. Only traces of microcystin-LR, -RR and -dmRR were detected by LC–HRMS in a few ng/L from both fractions, aqueous and sestonic. In contrast, different anabaenopeptins and oscillamide Y at unusually high concentrations (µg-mg/L) were observed. To our knowledge, no previous studies have detected these bioactive peptides at such high levels. The reliable identification of these cyanobacterial peptides was achieved by HRMS. Although recently these peptides are detected frequently worldwide, these bioactive compounds have received little attention. Therefore, more studies on these substances are recommended, especially on their toxicity, health risk and presence in water resources.
EFFECTS OF ~(60)Co γ-RAYS IRRADIATION ON SEED GROWTH OF GROUND-COVER CHRYSANTHEMUM

The seeds of ground-cover chrysanthemum were used to study the effects of different doses of 60Co γ-rays irradiation(10 ～ 50Gy) on seed germination and physiological characteristics.The results showed that the rate of seed germination and seedling survival decreased significantly with the irradiation doses.With the increase of irradiation dose to above 20Gy,the content of malondialdehyde(MDA) and activity of peroxidase(POD) in seedlings significantly increased.The similar trends were found in the activities of superoxide dismutase(SOD) and glutathione reductase(GR). Catalase(CAT) activity increased at doses lower than 20Gy,and then decreased at the higher doses,whereas ascorbate peroxidase(APX) activity did not alter except for 40Gy.It is concluded that the suitable irradiation dose of mutation breeding is 20Gy for the seeds of ground-cover chrysanthemum.Although 60Co γ-rays irradiation resulted in damage of membrane lipid peroxidation in the survival seedlings,the increased activity of CAT and POD could protect them against the damage.
Effects of Brief Exposure to High Temperature on Survival and Fecundity of Two Whitefly Species: Bemisia tabaci B-biotype and Trialeurodes vaporariorum (Homoptera: Aleyrodidae)

【Objective】The effects of brief exposure to high temperature on survival and fecundity of two whitefly species, Trialeurodes vaporariorum and Bemisia tabaci B-biotype (Homoptera: Aleyrodidae), were studied to understand occasional changes in the biological characteristic of whitefly species encountered high temperature stress. 【Method】The survival rate, longevity, reproduction and survival rate from egg to adult of F1 progeny of B. tabaci B-biotype and T. vaporariorum were evaluated after the adults were exposed to 37, 39, 41, 43 and 45℃ for 1 hour in climatic incubators. 【Result】The survival rates of adults of both whitefly species decreased with the increase of temperature. Within the range of 37 to 45℃, the survival rate of B. tabaci B-biotype adults decreased from 99.1% to 42.6%, and T. vaporariorum adults varied from 95.0% to 13.5%. After exposure to 45℃ for 1 h, the longevity of both sexual adults of B. tabaci B-biotype exceeded 10 days, while all T. vaporariorum died in 24 h. The reproduction per female of B. tabaci B-biotype varied with the exposure temperature, but there were no significant differences between the treated and the control female individuals. However, the total survival rate from egg to adult of F1 progeny that produced by heated adults of B. tabaci B-biotype decreased from 70.7% to 25.1%。 In the case of T. vaporariorum, the mean egg number of per T. vaporariorumfemale adult decreased from 62.4 to 1.5 within the range of 37℃ to 43℃ and the female adults ceased oviposition activity after exposure to 45℃ for 1 h. The total survival rate from egg to adult of F1 progeny that produced by adults of T. vaporariorum was significantly affected by experience of brief exposure to high temperature and the temperature that caused 50% and 90% F1 progeny individuals died exceed B. tabaci B-biotype by 1.6℃ and 4.7℃, respectively. 【Conclusion】There were significant differences between the two tested whitefly species in their adaptation to high temperature, and the heat tolerance of T. vaporariorum was significantly lower than that of B. tabaci B-biotype. The adults of B. tabaci B-biotype were found to be more adaptability to high temperature than that of T. vaporariorum in survival and fecundity, which could facilitate the population of B. tabaci B-biotype development in hot seasons. The adaptive divergence of tolerance to high temperature may be an important reason that leads to two whitefly species interspecific differentiation in seasonal dynamics and distribution in China.
How children learn : New perspectives in conceptual change research

Following on the footsteps of Professor Hatano we will try to present an approach to learning and conceptual change that bridges constructivist with socio-cultural perspectives. According to this approach, learning starts early in infancy and results in the accumulation of rich, everyday knowledge about the physical and social world in natural settings. We will argue that while knowledge acquisition processes are constructive attempts on the basis of individuals to make sense of the world around them, they are also deeply influenced by the social and cultural settings in which they participate. Examples from children’s knowledge acquisition processes in observational astronomy in different cultures will be presented to illustrate these arguments.
Uptake and Transport of Hydroxysafflor Yellow A in Caco-2 Cells Monolayer

OBJECTIVE To study the absorption mechanism of hydroxysafflor yellow A(HSYA) in gastrointestinal(GI) tract.METHODS Caco-2 cells monolayer was employed to investigate the effect of incubation time,pH of circumstance,drug concentration and inhibitors(cyclosporine A and NaN3) on HSYA uptake(or transport),and excretion experiments of HSYA in rats after intragastric administration was further conducted.RESULTS Uptake of HSYA in Caco-2 cells monolayer rising linearly with increasing concentration indicated a passive diffusion.Decreased uptake [(1.05±0.045) mg·g-1] of HSYA in Caco-2 cells was observed at pH 7.8 comparing to that at pH 5.4 [(1.24±0.09) mg·g-1]. The apparent permeability coefficient of(2.16±1.21)×10-8cm·s-1 for HSYA(1 g·L-1) in Caco-2 cells monolayer was increased dramatically to(47.92±17.8)×10-8 and(12.53±4.55)×10-8cm·s-1 by cyclosporin A and NaN3,respectively.Accumulative excretion of HSYA in urine and feces were 0.74% and 28.57% respectively after intragastric administration(5.6 mg·kg-1) in rats for 31 h.CONCLUSION Absorption process of HSYA in Caco-2 cells monolayer met the characteristics of passive diffusion and the efflux caused by P-gp was also involved.The membrane permeability of HSYA is extremely low and alkaline circumstance is disadvantageous for the HSYA absorption.The absorption of HSYA in GI tract is little and much more HSYA are excreted in feces or transformed by the metabolism enzymes in GI tract.
Correlation between gene polymorphisms of tumor necrosis factor-α promoter TNFα-238G/A and-308G/A and endometriosis

Objective:To explore the correlation between gene polymorphisms of tumor necrosis factor-α promoter TNFα-238G/A and-308G/A and endometriosis.Methods:The gene polymorphisms of tumor necrosis factor-α promoter TNFα-238G/A and-308G/A in endometriosis group(100 cases) and control group(100 cases) were detected by PCR-RELP.Results:The frequencies of TNFα-238 G/G,G/A and A/A phenotypes in endometriosis group were 0.93,0.07 and 0,respectively;the gene frequencies of TNFα-238 G and TNFα-238 A were 0.965 and 0.035,respectively;The frequencies of TNFα-308 G/G,G/A and A/A phenotypes in endometriosis group were 0.87,0.12 and 0.01,respectively;the gene frequencies of TNFα-308 G and TNFα-238 A were 0.93 and 0.07,respectively;there was no significant difference in genotype frequencies and gene frequencies of TNFα-238G/A and TNFα-308G/A between endometriosis group and control group(P0.05). Conclusion:There is no significant correlation between gene polymorphisms of TNFα-238G/A and TNFα-308G/A and endometriosis.
Eine HLA/OpenGIS basierte Servicearchitektur zur Abbildung raumzeitlicher Prozesse

Research on GIS-tools to manage spatio-temporal information still focuses on the improvement of database management systems and does not offer new approaches to integrate spatio-temporal processes and simulations with current GIS components. Standards to reach an interoperable geoservice architecture (OpenGIS) and a framework for interoperable dynamic simulation (HLA) emerge to a more or less stable state. This offers the chance to integrate these initiatives to support dynamic spatio-temporal monitoring and simulation. This paper shows first steps towards an architecture design. 1. Prozesse in Raum und Zeit Prozesse, für deren vollständige Beobachtung und Beurteilung Kenntnisse über ihre räumliche und zeitliche Varianz erforderlich sind, finden sich im gesamten derzeitigen Anwendungsspektrum der Geoinformatik. Diese umfassen sowohl die klassischen umweltrelevanten Fragestellungen (Goodchild et al. 1996, Grützner 1997), beispielsweise: • in der Meteorologie: Monitoring und Simulation atmosphärischer Schadstoffdispersionen (Bernard und Krüger 2000); • in der Hydrologie: Monitoring und Simulation von Hochwasserwellen (Streit und Wiesmann 1996); als auch Fragestellungen der neuen, stetig wachsenden Geoinformationsmärkte, wie z.B. : • in der Telekommunikation: die zeitlich variierende Auslastung von Funknetzzellen, die entsprechende Maßnahmen zur kurzoder mittelfristigen Anpassung eines Mobilfunknetzes erforderlich machen; 1 Institut für Geoinformatik, Universität Münster, Robert-Koch-Str. 26-28, D-48149 Münster, email: {bernard | wytzisk}@ifgi.uni-muenster.de, Internet: http://ifgi.uni-muenster.de 2 Fraunhofer-Institut für Fabrikbetrieb und -automatisierung, Sandtorstr. 22, D-39106 Magdeburg, email: uklein@iff.fhg.de, Internet http://www.iff.fhg.de EnviroInfo 2001: Sustainability in the Information Society Copyright 2001 Metropolis Verlag, Marburg, ISBN: 3-89518-370-9
Service Quality: Revisiting the Two Factors Theory

ABSTARCT Present paper is based on the findings of the ongoing Ajmer Experiments. Ajmer Experiments are quasi-experiments that inquire into the consumer evaluation of service quality. The paper presents the two factors’ theory of the author. The paper suggests that a more detailed approach is required wherein each factor needs to be considered independently and not as an aggregate dimension. The paper reports evidence to support two-factor theory for services that was dis carded by earlier researchers. The paper argues to differentiate between the factors and the outcome of performance along these factors. The study describes the two factors as ‘vantage factors’ and ‘qualifying factors’. Marketers need to be selective in that certain factors behave as vantage factors while others as qualifying factors. The two are different in nature and require a differential treatment. The paper also analyses the nature and behavior of these two types of factors. Managerial implications of these factors are also dealt with in this paper.
Effects of programmed exercising to music of female pupils

Former research has shown that present teaching curricula cannot provide the continuity of exercising and fulfillment of certain tasks in physical education teaching and that alterations are necessary. The following question arose as the consequence of the previous statement: Could aerobics be used in teaching physical education at primary schools, since it became a very popular form of exercising throughout the world, as well as in this country? The research was done on the sample of 95 female seventh grade pupils at primary school "Jovan Jovanovic Zmaj" in Kanjiza. They were divided into three groups (two experimental groups and one control group). Especially programmed teaching of aerobic exercises to music according to "step" and "high-low" aerobics (which was the experimental factor) was conducted in experimental groups, while Physical Education Curriculum regulated by the Ministry of Education of Serbia was conducted in the control group. The effects of programmed exercise to music were followed in the following areas: the area of variables of morphological characteristics (seven variables); the area of functional abilities (three variables) and the area of motor abilities (sixteen variables). The results of the research showed that programmed exercising to music according to the models of "step", and "high-low" aerobics had increased the improvement of morphological characteristics, functional and motor abilities of the seventh grade primary school female pupils, in comparison to the pupils from the control group. The greatest improvement in both models of aerobic exercise was noticed in the maximal oxygen uptake and variables from the area of general coordination and coordination in rhythm. Gained results of the research indicate that aerobic exercising to music in physical education teaching can be applied in practice, in order to dosage exercises precisely and fulfil the aims and tasks of physical education.
The Cubic Ternary Complex ReceptorOccupancy Model I. Model Description

Abstract In this paper we propose a new equilibrium model of the interactions between receptors, ligands, and G-proteins–the cubic ternary complex (CTC) model. The CTC model is a generalization of the extended ternary complex model of Samamaet al.(1993). It incorporates all the features of that model but differs in that it also allows G-proteins to bind to inactive receptors. The addition of this feature produces a complete equilibrium description of the three-way interactions between ligand, receptor, and G-proteins. We show that the standard equilibrium receptor-occupancy models of pharmacology are equivalent to the hierarchical log-linear models of statistics. Using this equivalence, we derive the completeness of the CTC model from both a graphical and a statistical perspective. In its simplest instance (one receptor, one G-protein, and one ligand) the CTC model consists of eight receptor species that can be graphically visualized as occupying the vertices of a cube. Statistically, the CTC model is a saturated three-factor log-linear model. Viewed statistically or graphically, other equilibrium binary and ternary complex models are subsets of the CTC model.