Miracle-dz/UniFAR-FTUs huggingface dataset:
Corporate social responsibility internal as a predictor for motivation to serve, normative commitment, and adaptive performance among State-owned Enterprises’ employee

Abstract Very drastic environmental changes require the development of an adaptive performance management framework that supports the strengths of the company’s structure. Proving the position of internal CSR as a resource that can solve performance problems needs to be done. This study aims to analyze the role of internal corporate social responsibility as a predictor of motivation to serve, normative commitment, and adaptive performance in Pandemic COVID 19 among State-owned enterprises Employees. The research design used causal studies to test the influence by using a survey of 289 employees holding State-owned Enterprises (SOEs) of the defense industry non-managers who were randomly selected. Findings of research show the motivation for high performance grows in line with the attention and support of the company at the time of pandemic with the existence of internal corporate social responsibility. Normative commitments increase and impact adaptive performance. Performance grows along with the activation of personal norms (moral responsibility) and the activity of individual values as employees in State-owned enterprises. The employees identify themselves as part of an organization that must devote itself to the interests of the state. Internal corporate social responsibility influences adaptive performance both directly and through motivation to serve and normative commitment. Theoretical implications are focused on developing ethical theories that underlie motivation to serve and normative commitments. Practical implications are focused on efforts to realize internal corporate social responsibility based on the foundation that is sourced on environmental ethical awareness. Originality is the contribution of expanding understanding of internal corporate social responsibility functions reviewed from the process to improve performance based on Self-determination theory and norm activation theory.
The Role of the Built Environment on the Quality of Life for Residents in Long-Term Care Facilities in Asia: A Scoping Review

Abstract Background and Objectives The quality of the built environmental features in long-term care (LTC) homes significantly influences residents’ functioning (e.g., wayfinding, self-care, and social interaction) and well-being. There is limited research on the characteristics of the built environment of LTC and its influence on residents’ quality of life in countries in the Asia–Pacific region (e.g., East Asia and South Asia). The older adult population in this region is expected to increase significantly in the coming decades. There are distinctive perceptions of nursing home, nursing home environments, and sociocultural norms in this geographic region. Given this context, a better understanding of the built environment of LTC facilities in this region can inform design professionals and policymakers for evidence-based decision-making. The present study undertakes a scoping review of the empirical research on the characteristics and influence of the built environment of LTC facilities on residents’ quality of life in the Asia–Pacific context. Research Design and Methods Online relevant databases were used to identify articles published 2000–2021, from which we selected 33 publications. Results Three substantive themes were generated from the synthesis of the selected publications. These themes are (a) perceptions of nursing home, (b) impact of the built environment on residents’ quality of life, and (c) assessment of the LTC built environment. Discussion and Implications We identified research gaps in understanding the role of the built environment in nursing homes in the particular geographic context and future research directions. Five planning and design principles for LTC were derived from the synthesis of key findings to inform design professionals and policymakers.
Thymoquinone Produces Cardioprotective Effect in β-Receptor Stimulated Myocardial Infarcted Rats via Subsiding Oxidative Stress and Inflammation

Earlier studies reported that long-term treatment with thymoquinone (TQ) at a high dose (20 mg/kg) exerts a cardioprotective effect against isoproterenol (ISO)-triggered myocardial infarction (MI) in rats. In the present study, we tested the hypothesis that TQ, as a potent molecule, can exhibit cardioprotective effects at the lower dose for a short-term regimen. The rats were administered with TQ (5 mg/kg, intraperitoneal) at the 4 h interval for 2 days. ISO (100 mg/kg/day, subcutaneous) was given for 2 days to produce MI. ISO challenge results in deformation in ECG wave front, elevated left ventricular (LV) end-diastolic pressure, and reduced LVdP/dtmax and LVdP/dtmin. The levels of the cardiac biomarker in serum, such as creatine kinase MB, alanine aminotransferase, and aspartate aminotransferase, were increased. In the myocardium, a rise in malonaldehyde and decreased superoxide dismutase, glutathione, and catalase contents were observed. Furthermore, increased levels of tumor necrotic factor-α, interleukin-6, and interleukin-1β were observed in the myocardium. TQ pretreatment significantly normalized alterations in hemodynamic parameters, strengthened the antioxidant defense system, and decreased the contents of pro-inflammatory cytokines and hepatic enzymes as compared to the ISO group. Based on the results, TQ appears to be cardioprotective at low doses, and effective even administered for a shorter duration.
Endothelial Autophagy in Coronary Microvascular Dysfunction and Cardiovascular Disease

Coronary microvascular dysfunction (CMD) refers to a subset of structural and/or functional disorders of coronary microcirculation that lead to impaired coronary blood flow and eventually myocardial ischemia. Amid the growing knowledge of the pathophysiological mechanisms and the development of advanced tools for assessment, CMD has emerged as a prevalent cause of a broad spectrum of cardiovascular diseases (CVDs), including obstructive and nonobstructive coronary artery disease, diabetic cardiomyopathy, and heart failure with preserved ejection fraction. Of note, the endothelium exerts vital functions in regulating coronary microvascular and cardiac function. Importantly, insufficient or uncontrolled activation of endothelial autophagy facilitates the pathogenesis of CMD in diverse CVDs. Here, we review the progress in understanding the pathophysiological mechanisms of autophagy in coronary endothelial cells and discuss their potential role in CMD and CVDs.
Bulletin of Electrical Engineering and Informatics

Received Jan 22, 2022 Revised May 9, 2022 Accepted Jun 14, 2022 Inertia phenomenon in steering vehicle is major factor that allow oversteering incident in which come from the insufficient steering and slip control over the vehicle itself. The efficient and robust control system is required to consider both precision and stability of the vehicle for better manuevering especially in cornering road. Therefore, this research has taken the initiative to contribute a better solution for vehicle control according to the mentioned problem and situation with a proposed robust super-twisting sliding mode control (ST-SMC) by simplified torque on wheel and steering angle input with decoupling lateral and longitudinal errors. This control technique approach to allow coping with the issue by reducing forces and inertia for optimum speed at the cornering period and with the almost precise steering positioning. The dynamic model of rack steering vehicle (RSV) is used as the model plant and the proposed control system is simulated for verification. The results shows that the proposed ST-SMC offers improved performance in terms of speed increase time and vehicle stability that gives impact to the RSV being skidded or collided to any obstacles during cornering period.
Quantifying the Resilience of Emergency Response Networks to Infrastructure Interruptions through an Enhanced Metanetwork-Based Framework

16 Building effective and resilient emergency response networks (ERN) is essential for the rapid recovery 17 of interrupted infrastructure during extreme events. Aiming at providing a critical benchmarking and 18 implementable strategies for improving ERN resilience, this study proposes a novel framework to 19 systematically quantify ERN resilience through an enhanced Meta-Network Analysis (MNA)-based 20 approach. This framework firstly applies the MNA approach to conceptualize the complex emergency 21 response as three-stage “Agent-Task-Resource-Knowledge” (A-T-R-K) meta-networks, representing connections among stakeholders, response tasks, emergency resources, and professional knowledge. Then, 23 suitable meta-network measures (i.e., natural connectivity, average speed, overall task completion, and the 24 integrative metric of task resource/knowledge needs and task resource/knowledge waste) generated 25 accordingly are used to quantify ERN resilience capacities—robustness, rapidity, resourcefulness, and 26 redundancy. This proposed framework is validated through a case study of the emergency response to the 27 Manchester Arena attack in the United Kingdom. The dynamic change of ERN resilience over time as well 28 as possible causes within the case scenario are analyzed. Additionally, its resilience improvement strategies 29 and the advantages of the MNA approach are discussed. Overall, this enhanced MNA-based framework 30 promotes an understanding of emergency response performance through systematically conceptualizing the 31 complex ERN structure and dynamically quantifying ERN resilience capacities. Lessons learned from 32 historical disasters provide decision-makers with implementable support to advance their collaboration and 33 knowledge sharing, and optimize resources and tasks for enhancing resilience in future infrastructure 34 operation and emergency response activities. 35
COVID-19 exposure and mental wellbeing of European male employees

Background: The present research intends to identify the determinants of men? s mental wellbeing during the COVID-19 pandemic. The fear and uncertainty caused by this pandemic and its prolongation have caused a considerable rise in mental health disorders. In a very short time, much research has been conducted examining the main consequences of the COVID-19 pandemic on individuals? mental health. Some studies pointed out that COVID-19 stressors significantly affect individuals, and some statistics suggest that the pandemic affects men and women differently. However, the literature on the effect of the COVID-19 pandemic on men? s mental health remains limited. This research attempted to fill these gaps in the literature by examining an essential research question about the determinants of men? s mental wellbeing during the COVID-19 pandemic. Methods: This research uses a dataset collected on Eurofound? s Living, Working, and COVID-19 survey, and the full sample consisted of 24,123 European citizens. The sample was split into two main groups: men (N = 3577) and women (N = 8744). This research uses linear regression methodology to investigate the mental wellbeing of male employees. The input method was applied to estimate two regression models, one for men and one for women. Results: Our results revealed that men? s exposure to COVID-19 infection deteriorates their mental wellbeing. Similarly, some organizational factors also determined men? s mental wellbeing, such as working under fixed employment contracts, feelings of doing useful work, and satisfaction with the quality of work. Finally, individual and attitudinal factors contributed to determining the mental wellbeing of male employees, optimism about the future, general health, positive feelings about themselves, and overall life satisfaction. Conclusion: This research deduces that men? s mental wellbeing is determined by factors that are different from those of women employees. In conclusion, this research deduces that men? s good mental wellbeing is determined differently from women employees. Specifically, we identified that exposure to COVID-19, employment contracts at the job, feelings of doing useful work, satisfaction with the quality of work, resilience, age, life satisfaction, general health, optimism about the future, and feeling positive about themselves are the key determinants of men? s health.
Therapeutic Potential of Mitotic Kinases’ Inhibitors in Cancers of the Gastrointestinal System

Mitosis entails mechanistic changes required for maintaining the genomic integrity in all dividing cells. The process is intricate and temporally and spatially regulated by the ordered series of activation and de-activation of protein kinases. The mitotic kinases ensure the stepwise progression of entry into mitosis after the G2 phase of the cell cycle, followed by prophase, pro-metaphase, metaphase, anaphase, telophase, and subsequently cytokinesis and birth of two daughter cells with equal segregation and distribution of the genome. The major mitotic kinases include cyclin-dependent kinase 1 (CDK1), Aurora A and B Kinases, and Polo-Like-Kinase 1 (PLK1), among others. Overexpression of some of these kinases has been reported in many cancers as the mitotic fidelity and genome integrity are interlinked and dependent on these regulators, the native irregularities in these factors can be targeted as therapeutic strategies for various cancers. Here, we report and summarize the recent updates on the literature describing the various mitotic inhibitors targeting kinases, which can be used as potential therapeutic interventions for gastrointestinal cancers including gastric cancer, liver cancer, pancreatic cancer and colorectal cancer.
Necrotizing Epididymo-Orchitis: A Rare Manifestation of COVID-19

Epididymo-orchitis is an infection of the epididymis and testis, one of the most common urogenital infections. It can be seen at any age. It is caused by sexually transmitted microorganisms and nonsexual transmitted pathogens. Viruses such as mumps and cytomegalovirus can also cause epididymo-orchitis. During the COVID-19 pandemic, in case of abnormal clinical manifestations of COVID infection and inadequate therapeutic response to the routine therapies, this disease with unusual manifestations should be considered. The case introduced in this paper is a 55-year-old man referred to a urology clinic with typical clinical presentations of epididymo-orchitis. Diagnosis by color Doppler examination and ultrasound also confirmed epididymo-orchitis. The patient underwent appropriate and routine treatment for epididymo-orchitis. Because of the lack of adequate clinical response and the continuation of fever and the development of scrotal lesions and the results of the control ultrasound, which suggested rupture of the tunica albuginea capsule, he underwent surgical exploration and subsequent orchiectomy. Due to the unconventional conditions and the usual culture and pathology, COVID-19 PCR was also performed on the tissues. The PCR showed tissue infection with COVID-19. The patient's clinical condition improved with an orchiectomy, the fever stopped, and he was discharged in a good general condition. It should be noted that before referral to the urology clinic and during hospitalization, evaluation, and treatment, the patient had no evidence in favor of respiratory tract infection with the coronavirus.
Synthesis of Antibacterial Hybrid Hydroxyapatite/Collagen/Polysaccharide Bioactive Membranes and Their Effect on Osteoblast Culture

Inspired by the composition and confined environment provided by collagen fibrils during bone formation, this study aimed to compare two different strategies to synthesize bioactive hybrid membranes and to assess the role the organic matrix plays as physical confinement during mineral phase deposition. The hybrid membranes were prepared by (1) incorporating calcium phosphate in a biopolymeric membrane for in situ hydroxyapatite (HAp) precipitation in the interstices of the biopolymeric membrane as a confined environment (Methodology 1) or (2) adding synthetic HAp nanoparticles (SHAp) to the freshly prepared biopolymeric membrane (Methodology 2). The biopolymeric membranes were based on hydrolyzed collagen (HC) and chitosan (Cht) or κ-carrageenan (κ-carr). The hybrid membranes presented homogeneous and continuous dispersion of the mineral particles embedded in the biopolymeric membrane interstices and enhanced mechanical properties. The importance of the confined spaces in biomineralization was confirmed by controlled biomimetic HAp precipitation via Methodology 1. HAp precipitation after immersion in simulated body fluid attested that the hybrid membranes were bioactive. Hybrid membranes containing Cht were not toxic to the osteoblasts. Hybrid membranes added with silver nanoparticles (AgNPs) displayed antibacterial action against different clinically important pathogenic microorganisms. Overall, these results open simple and promising pathways to develop a new generation of bioactive hybrid membranes with controllable degradation rates and antimicrobial properties.
Validating the Impact of Water Potential and Temperature on Seed Germination of Wheat (Triticum aestivum L.) via Hydrothermal Time Model

Wheat is the most extensively cultivated crop and occupies a central place in human nutrition providing 20% of the daily food calories. This study was conducted to find both T and ψ effects on wheat germination and the cardinal Ts value; a lab experiment was accomplished using HTT models. Cultivars were germinated under different accelerated aging periods (AAP, 0, 24, 48, and 72 h) at each of the following constant Ts of 15, 20, 25, 30, and 35 °C at each of the ψs of 0, −0.05, −0.1, −0.15, and −0.2 MPa. GR, GP, and other germination parameters (GI, GRI, CVG, SVI-I, SVI-II, GE, and MGT) were significantly determined by solute potential, temperature, and reciprocal action in both cultivars (p ≤ 0.01). Depending on the confidence interval of the model co-efficiently between cultivars, there was no significant difference. Hence, the average of cardinal Ts was 15, 20, and 35 °C for the Tb, To, and Tc, respectively, in the control condition (0 MPa). Hydro-time values declined when Ts was raised to To in cultivars, then remained constant at Ts ≥ To (2.4 MPah−1 in Pirsabak 15 and 0.96 MPah−1 in Shahkar). The slope of the relationship between ψb(50) and TTsupra with temperature when Ts is raised above To and reaches 0 at Tc. In conclusion, the assessed parameter values in this study can easily be used in simulation models of wheat germination to quantitatively characterize the physiological status of wheat seed populations at different Ts and ψs.
The Sustainability and Development Strategy of a Cattle Feed Bank: A Case Study

One of the Indonesian government’s policies to achieve national beef self-sufficiency is the 1000 beef village program. The program was piloted in many cattle-farming centers involving the operation of a feed bank to supply animal feed to tackle the challenge of feed limitation during the dry season. This study evaluates the sustainability status of an ongoing feed bank program and its development strategy based on the current progress of a feed bank used to serve five groups of farmers. Ninety sustainability attributes were derived based on six dimensions. The attributes were compiled from the primary data collected using a questionnaire. Expert opinions from practitioners were also considered in evaluating the attributes. The feed bank’s sustainability status and development strategy were determined using the multi-dimensional scaling method with the rapid appraisal approach. It was found that the overall sustainability status of the feed bank was less sustainable, with an overall score of 49.55. The individual dimensions of (A) policy and government support, (B) raw material, (C) facilities and infrastructure, (D) feed bank management, (D) human resource management, (E) price, production, and (F) distribution systems posed sustainability scores of 48.48, 60.33, 48.57, 47.89, 48.76, and 44.64, respectively. Among the 90 predefined attributes, 21 were identified as highly sensitive through both the root mean square and expert opinion. Those attributes led to five main recommended development strategies: (1) strengthening the institution, (2) intensifying training, (3) increasing human resources (4) partnership developments, and (5) increasing the role of multi-stakeholders.
Hematologic Malignancies Diagnosed in the Context of the mRNA COVID-19 Vaccination Campaign: A Report of Two Cases

Background: During the last two years, the COVID-19 pandemic led to millions of disease-related deaths worldwide. The efforts of the scientific community facing this global challenge resulted in outstanding achievements. Thus, within one year, new mRNA-based vaccines against SARS-CoV-2 viral infection were released, providing highly efficient protection and showing a very good safety profile in the general population. However, clinical data collection after vaccination is a continuous process for the long-term safety of any new medical product. The aim of our paper is to present two cases of hematological malignancies: diffuse large B-cell non-Hodgkin lymphoma and T/NK-cell lymphoma, diagnosed shortly after the administration of the mRNA COVID-19 vaccine. Methods and Results: Case 1: A female patient was admitted with a suspicious cervical mass that emerged within one week after the administration of second dose of the BNT162b2 COVID-19 vaccine. Surgical removal followed by pathology assessment of the specimen confirmed the diagnosis of diffuse large B-cell non-Hodgkin lymphoma. Case 2: A male patient was admitted with multiple ulcerative oral lesions arising on the third day after the initial dose of the BNT162b2 COVID-19 vaccine. These lesions had a progressive character and during the following months were complicated with repetitive episodes of heavy oral bleeding, requiring blood transfusions. The incisional biopsy of the lesions and pathological assessment of the specimens confirmed the diagnosis of T/NK-cell lymphoma. Conclusions: The safety profile of the mRNA-based vaccines is an undeniable fact. In most cases, suspicions of potentially aggressive side effects were ruled out, proving to be transient post-vaccine reactions. Clinicians should remain alert to report any potentially aggressive manifestations emerging in the context of mRNA COVID-19 vaccination, such as these cases of hematological malignancies, in order to promote additional investigations on the particular mechanisms of action of COVID-19 vaccines and to provide the best medical care to the patients.
Clinician-reported barriers to providing perinatal care to women with intellectual and developmental disabilities

ABSTRACT Background Research suggests that women with intellectual and developmental disabilities are at increased risk for adverse pregnancy outcomes. Further, they report unmet perinatal care needs. This qualitative study examined clinician perspectives on barriers to providing perinatal care to women with intellectual and developmental disabilities. Method We conducted semi-structured interviews and one focus group with US obstetric care clinicians (n = 17). We used a content analysis approach to code data and analyse them for larger themes and relationships. Results the majority of participants were white, non-Hispanic, and female. Participants reported barriers providing care to pregnant women with intellectual and developmental disabilities across individual (e.g., communication challenges), practice (e.g., identification of disability status), and system levels (e.g., lack of clinician training). Conclusions clinician training and evidence-based guidelines for perinatal care of women with intellectual and developmental disabilities as well as services and supports during pregnancy are needed.