Miracle-dz/UniFAR-FTUs huggingface dataset:
Th e Relationship Between Metastasis and MMP-9 in Sheep with Pulmonary Adenocarcinomas

: Th is study aimed to evaluate the role of Matrix Metalloproteinase-9 in the metastasis of ovine pulmonary adenocarcinoma cases by immunohistochemical methods. Lung tissue samples were collected from 26 sheep brought to our department for routine histopathological diagnosis. Lung tissues were fixed in 10% neutral buff ered formalin, following routine procedures tissues were embedded in paraffin wax. Sections from tissues were cut into 5 μm thickness and stained with Hematoxylin & Eosin to detect histopathological changes. Th e sections were examined under a light microscope and photographs were taken. Avidin-Biotin Peroxidase method was used as immunohistochemical staining. Tumoral cells showed acinar, papillary or mixed type growths in ovine pulmonary adenocarcinomas. Only 2 of 20 cases had metastases to lymph nodes, and tumoral cell proliferation in these metastic areas was similar to primary cancer foci. All ovine pulmonary adenocarcinomas were positive for JSRV CA and Matrix Metalloproteinase-9 immunoreactivity. Any positive expression of JSRV CA and Matrix Metalloproteinase-9 were not detected in the control group. Th e number of JSRV CA and Matrix Metalloproteinase-9 immune positive cells was statistically increased in the ovine pulmonary adenocarcinoma group compared to the control group. In line with the data of this study, it is thought that Matrix Metalloproteinases play a serious role in tumor metastasis in ovine pulmonary adenocarcinomas, especially Matrix Metalloproteinase-9.
International Journal of Electrical and Computer Engineering (IJECE)

Received Jun 21, 2021 Revised Feb 21, 2022 Accepted May 16, 2022 This paper introduces a new rectangular slot antenna structure based on a simple rectangular shape with two symmetrical rectangular slots on the radiated element. The aim of this work is to design an antenna and enhance it to function in the band (2.45 GHz and 5.8 GHz). We formulated the dimensions of the antenna using the transmission line model of the analytical methods and then we optimized these parameters using the CST Microwave Studio simulator. We made changes to two important parameters in our design: the position and width of the slots when the other parameters are kept constant. The resulting antenna provides good adaptation, high gain that achieves 5.96 dBi at 2.45 GHz and 6.491 dBi at 5.8 GHz, good return loss values of -49.859 dB and -34.303 dB for the lower and upper operating frequencies respectively. For radio frequency identification (RFID) implementations, the proposed antenna is ideal, and its main advantage is that it has high gain and is simple to design and fabricate.
NSS_A_348929 419..432

Purpose: The study aims to examine whether and how digital activities influence sleep issues among working Chinese youth. Methods: This study used data from the China Family Panel Studies (CFPS) a Chinese population-based survey, and employed the multilevel ordinal logistic regression model (MOLRM) to test the associations between digital engagement (whether to engage in digital activity, frequency, and duration) and sleep issues (bedtime, sleep duration, and quality) among Chinese working youth. Additionally, the restricted cubic spline model (RCSM) was adopted to fit the MOLRM to evaluate the nonlinear relationship between digital activity duration and sleep quality, and thus determine the optimal range of digital activity duration. Results: The analysis included 7849 working young adults. The digital usage rate was 84.11%. Digital use was not significantly associated with average, workday, or free-day sleep duration, after controlling for all potential confounders. However, most digital activity indicators could significantly predict bedtime and sleep quality. Furthermore, the RCSM indicated a non-linear relationship pattern between digital activity duration and sleep quality, with a weekly peak point of 25 h. Age significantly moderated the relationship between digital activity, sleep duration and bedtime. Younger youth who used digital media more frequently and for a longer time tended to sleep later and had shorter sleep duration than older youth. Conclusion: Digital usage significantly predicted later bedtime among Chinese working youth; however, it was not linked with sleep duration on workdays or free days. In parallel, a nonlinear correlation between digital activity duration and sleep quality indicated that appropriate digital activity duration (less than 25 h weekly) may contribute to good sleep quality.
Evaluation of Lightning Prediction by an Electrification and Discharge Model in Long-Term Forecasting Experiments

Over nearly three rainy seasons of lightning activity in North China, numerical prediction experiments were carried out using the Weather Research and Forecastingmodel coupled with electrification and discharge schemes (WRF-Electric). (e numerical forecast results were evaluated using the neighborhood-based equitable threat score (ETS) and fraction skill score (FSS) verification methods based on nationwide observational lightning data. An algorithm was used to generate the coverage of the total flash (intracloud and cloud-to-ground flashes) by fitting the cloud-to-ground flash data. (e numerical results showed that the region of lightning activity could be well predicted by the mesoscale WRF-Electric model, particularly during a 6–12-hour forecasting period. (e average ETS score of the 6–12-hour forecasting period was 0.34 for a 20 km neighborhood radius.(e predictive skill of the model varied not only monthly but also diurnally. (e model showed better forecasting skills during the main rainy season (June–July–August) and at 14 : 00–20 : 00 local time. (e predictability of the model was enhanced with increasing thunderstorm scale. On the other hand, the coverage of predicted lightning activity was relatively concentrated, and the lightning flash density was higher than the observations. (e main discrepancies in the model prediction were related to the design of the discharge parameterization. (us, in discharge parameterization, the initial threshold for lightning should bemodified according to themodel resolution, while themagnitude of the neutralization charge in a single discharge should be referenced to the observational results.
PREVALENCE OF PRE-OPERATIVE ANAEMIA IN SURGICAL PATIENTS AT THE RIVERS STATE UNIVERSITY TEACHING HOSPITAL

INTRODUCTION Pre-operative anaemia is a notifiable and modifiable risk factor for surgical patients. [1] It has been closely linked with increased post-operative morbidity, mortality and increased risk of peri-operative blood transfusion[1-2]. According to large observational study the prevalence of pre-operative anaemia ranges from 25% to 40%[1]. Establishment of pre-operative anaemia screening clinic is necessary to enhance the diagnosis and management of pre-operative ABSTRACT Background: Pre-operative anaemia is a notifiable and modifiable risk factor for surgical patients. It has been closely linked with increased post-operative morbidity, mortality and increased risk of peri-operative blood transfusion. According to large observational study the prevalence of pre-operative anaemia ranges from 25% to 40%. Establishment of pre-operative anaemia screening clinic is necessary to enhance the diagnosis and management of pre-operative anaemia. Aim: To determine the prevalence of pre-operative anaemia in surgical patients at the Rivers State University Teaching Hospital (RSUTH). Method: It was a cross sectional study of pre-operative patients at the Surgery and Obstetrics/Gyaecology departments of The Rivers State University Teaching Hospital. The cut-off for anaemia was 33% in line with the World Health Organization (WHO). The Information was retrieved from patients case notes using a structured profoma and analyzed using SPSS version 25. Results: A total of 370 patients were attended to pre-operatively. There were 146 (39.5%) males and 224 (60.5%) females. The mean age was 31 years. One hundred and ninety four (52.4%) were obstetrics and gynaecological surgeries while 176 (47.6 %) were non-gynaecological surgeries. The commonest indication for surgery was caesarean section representing 126 (34.1%) of the subjects. Two hundred and seventy two of the subjects(73.5%) had PCV less than 33%. One hundred and eighty four (67.9%) women had PCV less than 33% while 88 (32.1%) of the men had PCV less than 33%. Conclusion: The study revealed that prevalence of anaemia amongst pre-operative patients at RSUTH was 73.6%. Anaemia was highest amongst Obstetrics and gynaecological patients compared to other surgical patients.
The Acceptance of Primary Health Centre Information System Among Health Staff: An extended TAM Model

Ngaglik I Public Health Center in Sleman is one of the health centers that have already applied SIMPUS (an application of management information system for public health center). The implementation of clinical information systems could potentially improve the performance of health care facilities, save operational costs, and increase patient satisfaction. In fact, the clinical information systems applied by public health center vary. One of them is SIMPUS. However until present, there have not been any assessments of the acceptance of the clinical information system, especially SIMPUS, at Ngaglik I Public Health Center. To describe the use of SIMPUS at Ngaglik I Public Health Center and evaluate user understanding in accepting SIMPUS application based on the Technology Acceptance Model (TAM). This was a quantitative study which used a survey method and a cross-sectional design. The research sample consisted of 50 respondents who were selected using a simple random sampling method. The data analysis technique was the SEM-PLS analysis with the TAM model and SmartPLS software. Statistically, the relationship between the Job Relevance and Perceived Ease of Use variables was weak (p-value = 0.818). There was a weak relationship between Output Quality and Perceived Ease of Use (p-value = 0.208). There was a strong relationship between Result Demonstrability and Perceived Ease of Use (0.000). There was a strong relationship between Result Demonstrability and Intention to Use (p-value = 0.011). There was a weak relationship between Screen Design and Intention to Use (p-value = 0.870). There was a weak relationship between Perceived Ease of Use and intention to use. Users’ job relevance to SIMPUS did not have any effect on perceived ease of use. Output quality did not have any effect on perceived ease of use. The screen design of SIMPUS display had no effect on intention to use. Intention to use did not affect system use. Intention to use did not affect system use. Facilitating condition did not have any effect on system use. System use was influenced by perceived ease of use and intention to use. Perceived ease of use and intention to use were influenced by result demonstrability.
Microsoft Word-JSD_3A4_activation_mGlu5_PAM_revised_final_V4[1]

Drug Metabolism and Pharmacokinetics (A.L.B., T.M.B., F.W.B., R.D.M., J.S.D.), Medicinal Chemistry (M.L.T., M.E.M., C.W.L., S.R.S.), Molecular Pharmacology (C.K.J., C.M.N., P.J.C.) Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center. Nashville, TN, 37232. CREATe ADME/Tox, (C.M.), Neuroscience, Janssen Research and Development, Turnhoutseweg 30, B2340, Beerse, Belgium (H.L., G.J.M., T.S.) and Jarama 75, 45007-Toledo, Spain (J.M.B.). DMD Fast Forward. Published on September 3, 2013 as doi:10.1124/dmd.113. 052662
Optical Coherence Tomography

52 patients (76 eyes) with peripheral retinal tears, including 27 men and 25 women, aged 18 to 76 years. To visualize the periphery of the retina, we used a HOCT-1 / 1F HUVITZ spectral optical coherence tomograph (South Korea); photo registration was performed using a KANGHUA APS-BER fundus camera (China). All patients were examined with a Goldmann lens. The use of OCT made it possible to determine the structural features, the configuration of peripheral tears, the presence of vitreoretinal traction, morphometric parameters of the defects: average length, thickness of the retina at three standard points (before the break, in the region of the edge and bottom of the break), height, length of vitreoretinal adhesions and local detachment of the retinal neuroepithelium . Two groups of peripheral ruptures were identified: 1st (23 eyes) valvular ruptures, 2nd (43 eyes) perforated ruptures. OCT of peripheral retinal dystrophies is a highly informative method that allows in vivo assessment of the structure, morphometric parameters of defects, vitreoretinal adhesions, the presence of vitreoretinal traction and subclinical retinal detachment. This will allow documenting research results, establishing indications for laser and surgical treatment, and monitoring long-term results.
Study on Forecasting Approach to Short-term Load of SVM Based on Data Mining

The support vector machine (SVM) has been successfully applied to the load forecasting area, but it has some disadvantages of very large data amount and slow processing speed. Using advantages of the data mining technology in processing large data and eliminating redundant information, a SVM forecasting system based on data mining preprocess was proposed to search the historical daily load with the same meteorological category as the forecasting day and to compose data sequence with highly similar meteorological features. Taking the new data sequence as the training data of SVM, the data amount was decreased and the processing speed was improved. This approach has achieved greater forecasting accuracy comparing with the method of single SVM and BP neural network.
Parental Psychological Control, Attachment, and Perpetration of Psychological Aggression

viii Chapter I Parental Psychological Control, Attachment, and Perpetration of Psychological Aggression in Romantic Relationships . 1 Correlates and Predictors of Psychological Aggression . 2 Attachment Theory . 4 Attachment and Psychological Aggression . 8 Organized Attachment. 9 Disorganized Attachment. 10 Parenting . 12 Parental Psychological Control . 13 Parental Psychological Control and Attachment. 14 Parental Psychological Control and IPV . 16 The Current Study . 17 Chapter II Methods . 20 Participants . 20 Procedure . 21
Does US Fiscal Integration Stabilize Regional Business Cycles?∗

Yes. Using a semi-structural methodology for policy counterfactuals, I find that in a counterfactual US economy without fiscal integration the standard deviation of employment across states increases by about 1 percent in the Great Recession and 1.5 percent in the long-run. The key feature of fiscal union models that generate large stabilization gains is the presence of shocks to household demand. These shocks were important drivers of regional business cycles during the Great Recession. Taken together, these results help rationalize why previous work has found small gains instead, and inform policy discussions about future fiscal arrangements for the European Monetary Union. ∗I am indebted to my advisors Fernando Alvarez, Erik Hurst, and Veronica Guerrieri, for their encouragement, support, and guidance during my stay in Chicago, for our many insightful conversations, and for their patience and skill in distilling the important points from my presentations. For their valuable suggestions, I owe GeorgeMarios Angeletos, Andy Atkeson, Philip Haile, Ricardo Lagos, John Leahy, Martin Schneider, Gianluca Violante, and Ivan Werning as well as my classmates Jonathan Adams, Philip Barret, and Chanont Banternghansa. I thank those at the Review of Economic Studies Tour, Minneapolis Fed Junior Scholar Conference, SED, “Pizzanomics,” NBER SI Dynamic Equilibrium Models, and Macro Seminars at MIT, Harvard, Yale, Wharton, UCLA, GWU, Stanford, Princeton, NYU, Michigan, Northwestern, Cornell, Brown, LSE, BU, Berkeley, Fed Board, Atlanta Fed, Chicago Fed, BCRA, and Norges Bank. I thank all participants of the Capital Theory Working Group, especially Harald Uhlig and Nancy Stokey. Finally, I thank Juliette Caminade for her support and comments on preliminary versions of this paper. †E-mail: maberaja@mit.edu. Web: economics.mit.edu/faculty/maberaja
Surface Plasmon Resonance Imaging (SPRi) and Photonic Integrated Circuits (PIC) for COVID-19 Severity Monitoring

Direct optical detection methods such as surface plasmon resonance imaging (SPRi) and photonic-integrated-circuits (PIC)-based biosensors provide a fast label-free detection of COVID-19 antibodies in real-time. Each technology, i.e., SPRi and PIC, has advantages and disadvantages in terms of throughput, miniaturization, multiplexing, system integration, and cost-effective mass production. However, both technologies share similarities in terms of sensing mechanism and both can be used as high-content diagnostics at or near to point of care, where the analyte is not just quantified but comprehensively characterized. This is significant because recent results suggest that not only the antibody concentration of the three isotypes IgM, IgG, and IgA but also the strength of binding (affinity) gives an indication of potential COVID-19 severity. COVID-19 patients with high titers of low affinity antibodies are associated with disease severity. In this perspective, we provide some insights into how SPR and PIC technologies can be effectively combined and complementarily used for a comprehensive COVID-19 severity monitoring. This opens a route toward an immediate therapy decision to provide patients a treatment in an early stage of the infection, which could drastically lowers the risk of a severe disease course.
International Migration Projections across Skill Levels in the Shared Socioeconomic Pathways

International migration is closely tied to demographic, socioeconomic, and environmental factors and their interaction with migration policies. Using a combination of a gravity econometric model and an overlapping generations model, we estimate the probability of bilateral migration among 160 countries in the period of 1960 to 2000 and use these findings to project international migration flows and their implications for income inequality within and between countries in the 21st century under five shared socioeconomic pathways (SSPs). Our results show that international migration increases welfare in developing countries, and closes the inequality gap both within and between low-skilled and high-skilled labor in these countries as well. In most developed countries, on the contrary, international migration increases the inequality gap and slightly reduces output. These changes are not uniform, and vary significantly across countries depending on their population growth and human capital development trajectories. Overall, while migration is strongly affected by inequality between developed and developing countries, it has an ambiguous impact on inequality within and between countries.
Editorial: Special Issue on Replicability in Cognitive Science

This special issue on what some regard as a crisis of replicability in cognitive science (i.e. the observation that a worryingly large proportion of experimental results across a number of areas cannot be reliably replicated) is informed by three recent developments. First, philosophers of mind and cognitive science rely increasingly on empirical research, mainly in the psychological sciences, to back up their claims. This trend has been noticeable since the 1960s (see Knobe, 2015). This development has allowed philosophers to draw on a wider range of relevant resources, but it also makes them vulnerable to relying on claims that may not survive further scrutiny. If we have reasons to believe that a large proportion of findings in the psychological sciences cannot be reliably replicated, this would be a problem for philosophers who use such findings in their work. Second, philosophers are increasingly designing and carrying out their own experiments to back up claims, or to test claims earlier made from the armchair, for example, on the perceived permissibility of diverting trolleys or on the nature of free will. This growing field of experimental philosophy has diversified the intellectual field in philosophy, but may also be vulnerable to issues of replicability that philosophers did not face before. Third, the recent evidence of apparently widespread non-replicability in the social sciences (and other fields) has forced philosophers of science to grapple with long standing questions from their field from a new perspective. To what extent does replicability matter for theory construction? How do the notions of replicability and scientific progress interact? How can normative insights from philosophy of science be used in order to improve scientific practice? It is with these three developments in mind—the increasing importance of empirically-informed philosophy, of experimental philosophy, and of philosophy of science around replicability—that this special issue has been conceived.
On entanglement swapping and teleportation with local hidden variables

A model with local hidden variables is presented, which describes phenomena such as entanglement swapping and teleportation and also reproduces the quantum mechanical expectation values for the measurement of entangled photons. It refutes Bell's theorem and at the same time expands our physical understanding of entangled states since it can also explain the phenomena mentioned above. 1 Eugen Muchowski, Independent researcher, Vaterstetten, Germany, eugen@muchowski.de
NBER WORKING PAPER SERIES INCOME DIFFERENCES AND PRICES OF TRADABLES

I am grateful to Timothy J. Kehoe and Fabrizio Perri for their continued guidance and encouragement throughout this project. I also thank George Alessandria, Cristina Arellano, Costas Arkolakis, Patrick Bajari, Robert Feenstra, Cecilia Fieler, Ioanna Grypari, Pete Klenow, Narayana Kocherlakota, Lin Lu, Erzo Luttmer, Ellen McGrattan, Marc Melitz, Gina Pieters, Daniel Samano, Philip Saure, Michael Waugh, members of the Trade and Development Workshop at the University of Minnesota, as well as participants at various seminars and conferences for their comments and suggestions. All remaining errors are mine. Financial support from the Graduate Research Partnership Program Fellowship is gratefully acknowledged. I am grateful to the World Bank for generously providing me with the price data from the 2005 ICP round. The views expressed herein are those of the author and do not necessarily reflect the views of the National Bureau of Economic Research.
Climate change, development, and conflict-fragility nexus in the Sahel

More than 40 years after a catastrophic famine struck the region, the Sahel has once again become the focus of global attention. Poor economic performance, growing instability, and deteriorating climate conditions have combined to produce a vicious circle of increased poverty, instability, and communal violence. By drying out sources of livelihoods for populations mainly dependent on natural resources, climate change reinforces long-existing rivalries and increasingly triggers violence. In this paper, we argue that while climate change is a proximate cause of violence, institutional failures and clientelism1 are the actual root causes.