Miracle-dz/UniFAR-FTUs huggingface dataset:
The mitochondrial genome of one ‘twisted-wing parasite’ Xenos cf. moutoni (Insecta, Strepsiptera, Xenidae) from Gaoligong Mountains, Southwest of China

Abstract The nearly complete mitochondrial genome (mitogenome) of Xenos cf. moutoni, one twisted-wing parasite on wasp Vespa velutina from Southwest of China, is described in this study. The total length of this mitogenome is 16,717 bp, containing 13 protein-coding genes (PCGs), 22 transfer RNA genes (tRNAs), two ribosomal RNA genes (rRNAs) and an incomplete A + T-rich control region . All of the 13 PCGs are initiated with canonical ATN (N represents A, T, G, C) as start codons; 8 PCGs are terminated with a complete typical stop codon TAA, and the remaining five PCGs (cox2, cox3, nad3, nad4 and nad5) have an incomplete stop codon with just a T. The phylogenetic analysis based on the nucleotide sequences of PCGs and rRNAs indicates that Xenos cf. moutoni has a close relationship with Xenos vesparum, confirming its placement in the family Xenidae.
COVID-19 Disruptions to Endoscopic Surveillance in Lynch Syndrome

The COVID-19 pandemic has led to unprecedented disruptions in cancer screening, which may have disproportionate effects on individuals at increased cancer risk, including those with Lynch syndrome. Herein, we show that the COVID-19 pandemic led to significant disruptions in Lynch syndrome surveillance with potentially impactful delays, thus highlighting the importance of ensuring timely surveillance among this high-risk cohort. Disruptions in cancer screening due to the COVID-19 pandemic may disproportionally affect patients with inherited cancer predisposition syndromes, including Lynch syndrome. Herein, we study the effect of the COVID-19 pandemic on endoscopic surveillance in Lynch syndrome through a prospective study of patients with Lynch syndrome at a tertiary referral center who were scheduled for endoscopic surveillance during the COVID-19 pandemic shutdown between March 16, 2020 and June 4, 2020. Of our cohort of 302 individuals with Lynch syndrome, 34 (11%) had endoscopic procedures scheduled during the COVID-19 pandemic shutdown. Of the 27 patients whose endoscopic surveillance was canceled during this period, 85% rescheduled procedures within 6 months with a median delay of 72 days [interquartile range (IQR), 55–84 days], with identification of an advanced adenoma or gastrointestinal cancer in 13%. Individuals who did not have a rescheduled endoscopic procedure were significantly younger than those with a rescheduled procedure [age 35 (IQR, 26–43) vs. age 55 (IQR, 43–63), P = 0.018]. Male sex was also suggestive of increasing likelihood of not having a rescheduled procedure. Taken together, our study demonstrates that the COVID-19 pandemic shutdown led to delayed endoscopic surveillance in Lynch syndrome, with potentially impactful delays among young patients. These data also emphasize the importance of timely surveillance in Lynch syndrome during this current, as well as potential future, global pandemics. Prevention Relevance: The COVID-19 pandemic has led to unprecedented disruptions in cancer screening, which may have disproportionate effects on individuals at increased cancer risk, including those with Lynch syndrome. Herein, we show that the COVID-19 pandemic led to significant disruptions in Lynch syndrome surveillance with potentially impactful delays, thus highlighting the importance of ensuring timely surveillance among this high-risk cohort.
Hydrogen adsorption on sp2-bonded carbon: Influence of the local curvature

The interaction of atomic hydrogen and low-energy hydrogen ions with sp 2 -bonded carbon is investigated on the surfaces of C 6 0 multilayer films, single-walled carbon nanotubes, and graphite (0001). These three materialshave been chosen to represent sp2-bonded carbon networks with different local curvatures and closed surfaces (i.e. no dangling bonds). Chemisorption of hydrogen on these surfaces reduces emission from photoemission features associated with the π electrons and leads to a lowering of the work function up to 1.3 eV. It is found that the energy barrier for hydrogen adsorption decreases with increasing local curvature of the carbon surface. Whereas in the case of C 6 0 and single-walled carbon nanotubes, hydrogen adsorption can be achieved by exposure to atomic hydrogen, the hydrogen adsorption on graphite (0001) requires H + ions of low kinetic energy (∼1 eV). On all three materials, the adsorption energy barrier is found to increase with coverage. Accordingly, hydrogen chemisorption saturates at coverages that depend on the local curvature of the sample and the form of hydrogen (i.e., atomic or ionic) used for the treatment.
Voices of Resistance and Agency: LBTQ Muslim Women Living Out Intersectional Lives in North America

ABSTRACT This qualitative study critically examined, from an interpretive perspective, 14 life stories of LBTQ Muslim women across North America. This paper explored how LBTQ Muslim women navigated Muslim and LGBTQ hegemonic norms and exclusions as they negotiated and lived out identity intersections. Transnational and critical race feminisms, intersectionality, and critical Islamic liberationist approaches to gender and sexuality framed the project. The study findings suggested that LBTQ Muslim women resisted hegemonic norms by mapping out alternative paths grounded in Islam, and in living out lives in LGBTQ communities. Participants discussed their experiences of being “othered” within LGBTQ communities, how they challenged the notion of a monolithic Islam, how they expanded coming-out frameworks to include their own experiences, as well as how they asserted their own religious agency and resistance. Participants demonstrated that living out an intersectional identity was a complex task where constant negotiations of positionality were transpiring concurrently.
Combined treatment of ureteropelvic junction obstruction and renal calculi with robot‐assisted laparoscopic pyeloplasty and laser lithotripsy in children: Case report and non‐systematic review of the literature

The incidence of urinary tract stone disease is steadily increasing in both adult and paediatric populations. This condition develops due to different factors: dietary or metabolic alterations, infection, and congenital anatomic malformations. Standard indications and treatments for children are analogous to the ones indicated for adults. Extracorporeal shock wave lithotripsy, ureterorenoscopy and percutaneous nephrolithotomy (PCNL) should be preferred to more invasive techniques. Moreover, the introduction of laparoscopic and robot‐assisted laparoscopic approaches have improved surgical outcomes, lowering the bleeding risk with higher stone‐free rates, even in complicated cases. Despite these well‐known improvements, there are few reports regarding laparoscopic robot‐assisted management for urinary tract stone disease in paediatric patients under the age of 10, especially with concomitant treatment of ureteropelvic junction obstruction and multiple calyceal stones.
A multifaceted analysis reveals two distinct phases of chloroplast biogenesis during de-etiolation in Arabidopsis

Light triggers chloroplast differentiation whereby the etioplast transforms into a photosynthesizing chloroplast and the thylakoid rapidly emerges. However, the sequence of events during chloroplast differentiation remains poorly understood. Using Serial Block Face Scanning Electron Microscopy (SBF-SEM), we generated a series of chloroplast 3D reconstructions during differentiation, revealing chloroplast number and volume and the extent of envelope and thylakoid membrane surfaces. Furthermore, we used quantitative lipid and whole proteome data to complement the (ultra)structural data, providing a time-resolved, multi-dimensional description of chloroplast differentiation. This showed two distinct phases of chloroplast biogenesis: an initial photosynthesis-enabling ‘Structure Establishment Phase’ followed by a ‘Chloroplast Proliferation Phase’ during cell expansion. Moreover, these data detail thylakoid membrane expansion during de-etiolation at the seedling level and the relative contribution and differential regulation of proteins and lipids at each developmental stage. Altogether, we establish a roadmap for chloroplast differentiation, a critical process for plant photoautotrophic growth and survival.
Real‐world outcomes of ibrutinib therapy in Korean patients with relapsed or refractory mantle cell lymphoma: a multicenter, retrospective analysis

Dear Editor, Despite the introduction of novel front-line therapies including rituximab plus high-dose cytarabine followed by consolidative autologous stem cell transplantation (ASCT) and salvage therapy with bendamustine, lenalidomide or bortezomib, mantle cell lymphoma (MCL) is still considered incurable and most patients experience relapse or refractory (RR) disease. Ibrutinib (Imbruvica R ©) is a firstin-class oral agent that mainly works by inhibiting Bruton’s tyrosine kinase and is considered the standard of care for RR MCL. However, reports for outcomes and safety profiles of ibrutinib treatment in Asian RR MCL patients are limited as MCL accounts for less than 3% of NonHodgkin’s lymphomas in Asia [1, 2]. To evaluate the realworld outcomes of ibrutinib therapy in RR MCL patients in Korea, we performed a retrospective analysis of patients with RRMCL who were treated with ibrutinib from 18 tertiary institutes (details are provided in the Supplementary Materials). A total of 88 patients were analyzed. Their immunophenotypic and cytogenetics features at the time of diagnosis are shown in Supplementary Table S1. 71 (80.7%) patientsweremale. Three (3.4%) patients had blastoid variants MCL. At the time of initial diagnosis, their median age was 67 (range: 40-90) years. A total of 11 (12.5%) patients were classified as stage II and 77 (87.5%) as stage III-IV. All patients received combination chemotherapy with or without rituximab as front-line treatment. Rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) was the most frequently used regimen (n = 59, 67.0%), followed by rituximab plus fractionated cyclophosphamide, vincristine, doxorubicin, and
‘It is good to have a target in mind’: qualitative views of patients and parents informing a treat to target clinical trial in juvenile-onset systemic lupus erythematosus

Abstract Objective We sought to explore patient and parental views on treatment targets, outcome measures and study designs being considered for a future JSLE treat-to-target (T2T) study. Methods We conducted topic-guided, semistructured interviews with JSLE patients and parents and analysed the audio recorded interviews using thematic approaches. Results Patients and parents differed regarding symptoms they felt would be tolerable, representing ‘low disease activity’. Patients often classed symptoms that they had previously experienced, were ‘invisible’ or had minimal disruption on their life as signs of low disease activity. Parents were more accepting of visible signs but were concerned about potential organ involvement and symptom severity. Overall, patients and parents preferred that children were entirely asymptomatic, with no ongoing treatment side effects. They regarded fatigue as particularly challenging, requiring proper monitoring using a fatigue patient-reported outcome measure. Most families felt that reducing corticosteroids would also be a good treatment target. Overall, families liked the concept of T2T, commenting that it could help to improve disease control, help structure treatment and improve communication with clinicians and treatment compliance. They were concerned that T2T might increase the frequency of hospital visits, thus impacting upon schooling, parental employment and finances. Families made suggestions on how to modify the future trial design to mitigate such effects. Conclusion This study provides guidance from patients and parents on T2T targets and study designs. Complementary quantitative studies assessing the achievability and impact of different targets (e.g. lupus low disease activity state or remission) are now warranted to inform an international consensus process to develop treatment targets.
Exploring the temporal dimensions of student engagement with longitudinal assessment in an oral health therapy programme

Abstract The time and effort students devote to learning tasks has been related to student success and outcomes, however, the way students understand and experience time during their health professional education remains poorly understood. This article aims to address this gap in knowledge through a qualitative analysis of health professional students’ engagement with a longitudinal portfolio assessment spanning two years. Thematic analysis of 7 focus groups conducted with oral health therapy students was performed. Four temporal dimensions of student engagement associated with the longitudinal portfolio assessment were identified: the organising effect of the assessment structure and timeline; flows of learning over time; individual perceptions of time; and having a future orientation. A fifth theme identified that circumstances or events can make or break the temporal rhythms of any of the dimensions. Our findings show that students’ experiences of learning are affected by institutional arrangements as well as personal perceptions of time. Taking the experience of time beyond the concept of ‘time management’, we show how curricula contain under-recognised tools for students to authentically experience the complexities and contradictions of time in preparation for the context of health practice.
Foliar application of 3-hydroxy-4-pyridinone Fe-chelate [Fe(mpp)3 ] induces responses at the root level amending iron deficiency chlorosis in soybean.

Iron (Fe) deficiency chlorosis (IDC) affects the growth of several crops, especially when growing in alkaline soils. The application of synthetic Fe-chelates is one of the most commonly used strategies in IDC amendment, despite their associated negative environmental impacts. In a previous work, the Fe-chelate tris(3-hydroxy-1-(H)-2-methyl-4-pyridinonate) iron(III) [Fe(mpp)3 ] has shown great potential for alleviating IDC in soybean (Glycine max) in the early stages of plant development under hydroponic conditions. Herein, its efficacy was verified under soil conditions in soybean grown from seed to full maturity. Chlorophyll levels, plant growth, root and shoot mineral accumulation (K, Mg, Ca, Na, P, Mn, Zn Ni, and Co) and FERRITIN expression were accessed at V5 phenological stage. Compared to a commonly used Fe chelate, FeEDDHA, supplementation with [Fe(mpp)3 ] led to a 29% higher relative chlorophyll content, 32% higher root biomass, 36% higher trifoliate Fe concentration and a two-fold increase in leaf FERRITIN gene expression. [Fe(mpp)3 ] supplementation also resulted in increased accumulation of P, K, Zn and Co. At full maturity, the remaining plants were harvested and [Fe(mpp)3 ] application led to a 32% seed yield increase when compared to FeEDDHA. This is the first report on the use of [Fe(mpp)3 ] under alkaline soil conditions for IDC correction, and we show that its foliar application has a longer-lasting effect than FeEDDHA, induces efficient root responses and promotes the uptake of other nutrients.
Phylogenetically-controlled correlates of primate blinking behaviour

Eye blinking is an essential maintenance behaviour for many terrestrial animals, but is also a risky behaviour as the animal is unable to scan the environment and detect hazards while its eyes are temporarily closed. It is therefore likely that the length of time that the eyes are closed and the length of the gap between blinks for a species may reflect aspects of the ecology of that species, such as its social or physical environment. An earlier published study conducted a comparative study linking blinking behaviour and ecology, and detailed a dataset describing the blinking behaviour of a large number of primate species that was collected from captive animals, but the analysis presented did not control for the nonindependence of the data due to common evolutionary history. In the present study, the dataset is reanalysed using phylogenetic comparative methods, after reconsideration of the parameters describing the physical and social environments of the species. I find that blink rate is best described by the locomotion mode of a species, where species moving through arboreal environments blink least, ground-living species blink most, and species that use both environments show intermediate rates. The duration of a blink was also related to locomotion mode, and positively correlated with both mean species group size and mean species body mass, although the increase in relation to group size is small. How a species moves through the environment therefore appears to be important for determining blinking behaviour, and suggests that complex arboreal environments may require less interruption to visual attention. Given that the data were collected with captive individuals, caution is recommended for interpreting the correlations found.
Does Psychological Capital Mediate Between Workplace Violence and Depressive Symptoms Among Doctors and Nurses in Chinese General Hospitals?

Background Depressive symptoms related to workplace violence (WPV) have been studied and are the main causes of lower psychological and physical well-being and work motivation. Our study aims to examine the prevalence of depressive symptoms and to explore whether psychological capital (PsyCap) mediates the effect of WPV on depressive symptoms in doctors and nurses. Methods Participants were recruited from general hospitals in Liaoning, China in 2018. Out of 1218 participants, 1062 (87.2%) completed self-reported questionnaires. Depressive symptoms, WPV and PsyCap were measured by Epidemiologic Studies Depression Scale (CES-D), Workplace Violence Scale (WVS) and Psychological Capital Questionnaire (PCQ), respectively. The related factors of depressive symptoms were investigated by using hierarchical multiple regression in both doctors and nurses. Results The mean scores of depressive symptoms were 23.09 ± 8.38 in doctors and 22.33 ± 8.95 in nurses, and there was no significant difference between the scores of these two groups. WPV was positively associated with depressive symptoms (doctors: β=0.349, P<0.001; nurses: β=0.317, P<0.001) while PsyCap was negatively associated with depressive symptoms (doctors: β=−0.101, P<0.001; nurses: β=−0.230, P<0.001). In addition, PsyCap acted as a mediating role between WPV and depressive symptoms in both doctors and nurses. Conclusion Both doctors and nurses had serious depressive symptoms. WPV could aggravate depressive symptoms, while PsyCap could aggravate against depressive symptoms. When PsyCap acted as a mediator, WPV had a negative impact on PsyCap, which could increase doctors’ and nurses’ depressive symptoms.
Tin oxide with a p–n heterojunction ensures both UV and visible light photocatalytic activity

Tuning of the tin oxide (SnO/SnO2) heterojunction (TOHJ) has been made possible by heating the as-prepared p-type SnO semiconductor in air in a controlled fashion. Thus a better photocatalytic activity for dye degradation under UV, visible as well as solar light irradiation was achieved. Multiple reflection of light and the TOHJ of SnO plates facilitate the photocatalysis reactions.
Can Ferritin Levels Predict the Severity of Illness in Patients With COVID-19?

Objectives: This study aimed to investigate whether ferritin level can predict the severity of coronavirus disease 2019 (COVID-19). Background: The COVID-19 pandemic has been challenging for both patients and caregivers. Many laboratory markers have been used to better understand the causes of poor outcomes and to improve the management of COVID-19 patients. Methods: A total of 93 patients who had a positive polymerase chain reaction test result for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were included in this study. Demographic features, comorbidities, clinical and laboratory findings were obtained from the hospital database retrospectively. Patients were divided into two groups according to the disease severity as follows: mild group (n = 70) and severe group (n = 23). Results: The median age of the study population was 42.5 (28.3-62.8) with 69.9% male patients. Patients in the severe group were significantly older and showed a higher frequency of hypertension, diabetes mellitus, coronary artery disease, and heart failure in comparison with those in the mild group. In addition, gamma-glutamyl transferase, C-reactive protein, ferritin, interleukin-6, procalcitonin, and neutrophil to lymphocyte ratio were higher whereas albumin level was lower in patients in the severe group. Linear regression analysis demonstrated that ferritin level was the only significant predictor of disease severity (β = 0.487, t = 2.993, p = 0.004). In receiver operator characteristics curve analysis, ferritin level ≥264.5 ng/mL predicted severe COVID-19 with a sensitivity of 73.9% and specificity of 94.2%. Conclusion: Early analysis of ferritin levels in patients with COVID-19 might effectively predict the disease severity.
Non-pharmaceutical interventions and inoculation rate shape SARS-CoV-2 vaccination campaign success

Abstract Nearly 1 year into the coronavirus disease 2019 pandemic, the first severe acute respiratory syndrome coronavirus 2 vaccines received emergency use authorisation and vaccination campaigns began. A number of factors can reduce the averted burden of cases and deaths due to vaccination. Here, we use a dynamic model, parametrised with Bayesian inference methods, to assess the effects of non-pharmaceutical interventions (NPIs) (such as social distancing, mask mandates, school and workplace closure), and vaccine administration and uptake rates on infections and deaths averted in the United States. We show that scenarios depicting higher compliance with NPIs avert more than 60% of infections and 70% of deaths during the period of vaccine administration, and that increasing the vaccination rate from 5 to 11 million people per week could increase the averted burden by more than one-third. These findings underscore the importance of maintaining NPIs and increasing vaccine administration rates.