Optimizing Postoperative Analgesia The Use of Global Outcome Measures

ANESTHESIOLOGY is a dynamic specialty that has adapted well to demands from patients to improve the quality of their care and pressures from the healthcare industry to achieve this in a cost-effective fashion. The aging of the population undergoing surgical procedures, increasing proportion of surgical procedures performed in an outpatient setting, and emphasis on cost containment have led clinicians to modify several aspects of perioperative care, including postoperative pain control. Evidence from controlled studies indicates that epidural analgesia is an important and effective method of postoperative analgesia and may lead to a decrease in perioperative morbidity and mortality. The study by Carli et al. in this issue of ANESTHESIOLOGY suggests that there may be additional benefits of postoperative epidural analgesia. Our increased awareness that perioperative stress may adversely influence postoperative recovery has renewed our attempts to identify optimal postoperative analgesic techniques. For example, investigators who compared the benefits of postoperative patient-controlled analgesia using intravenous opioids to postoperative epidural analgesia reported that postoperative epidural analgesia is preferable based on traditional outcomes, such as pain intensity and time to first flatus and bowel movement. Only a few studies examining the impact of postoperative epidural analgesia on morbidity or mortality, however, have properly controlled the confounding influence of differences in intraoperative anesthetic technique. Despite this lack, studies suggest that a multimodal regimen to facilitate patient convalescence maximizes the benefits of postoperative epidural analgesia. The effective use of postoperative epidural analgesia increases costs and requires additional resources. Therefore, if this technique is to be generally adopted, we must determine its “value for the money. ” This will require a careful comparison of the effects of postoperative epidural analgesia with other standard techniques, and this comparison should incorporate global outcome measures of function and patient preferences, such as health-related quality of life (HRQL). The HRQL measure provides a comprehensive evaluation of a patient’s health status from the patient’s perspective. It considers the impact of health on physical and social functioning as well as on the individual’s perception of physical, mental, and social well-being. Although many investigators use HRQL to assess clinical interventions in other fields (e.g., oncology, surgery, internal medicine, and chronic pain), its use is relatively uncommon in anesthesiology research. This may reflect the fact that anesthesiologists, like other healthcare providers who only interact with patients on an acute basis, are generally familiar with “traditional” outcome measures (e.g., mortality and morbidity) and may view “nontraditional” outcome measures as “soft” or “unscientific. ” Furthermore, clinicians typically have difficulty translating a significant difference in HRQL into a “clinically meaningful” outcome, perhaps because we lack sufficient data to model this relationship. However, one could postulate ways that perioperative epidural analgesia, which generally provides superior pain control compared to systemic opioids, might improve certain HRQL subgroups (e.g., bodily pain, physical functioning, vitality) and, thus, overall HRQL and functional status. Postoperative epidural analgesia may also improve overall patient satisfaction, which, in turn, may positively affect additional HRQL subgroups. The excellent study by Carli et al. in this issue, therefore, is significant because it compares the effects of epidural analgesia to intravenous patient-controlled opioid analgesia on valid, well-defined functional outcomes and on HRQL after colonic surgery. Each group of patients in this study received a similar multimodal regimen, including early oral nutrition, aggressive postoperative mobilization, and avoidance of nasogastric tubes; however, the group that received epidural analgesia had significantly lower pain and fatigue scores and could mobilize sooner than the intravenous opioid group. In addition, compared with the intravenous opioid group, the patients who received epidural analgesia had an earlier return of gastrointestinal function that favorably affected their nutritional status by facilitating oral intake. As a result, the epidural group met the prospectively defined discharge criteria sooner than did the intravenous opioid group. These findings add weight to the idea that the incorporation of epidural analgesia into a multimodal analgesic regimen will have a positive impact on postoperative functional status and HRQL. This Editorial View accompanies the following article: Carli F, Mayo N, Klubien K, Schricker T, Trudel J, Belliveau P: Epidural analgesia enhances functional exercise capacity and healthrelated quality of life after colonic surgery: Results of a randomized trial. ANESTHESIOLOGY 2002; 97:540–9.