Miracle-dz/UniFAR-FTUs huggingface dataset:
Quality of life of 8- to 12-year-old children with autism spectrum disorder in Colombo district, Sri Lanka; perspective of primary caregivers

Introduction : Autism spectrum disorder (ASD) is a lifelong neurodevelopmental disorder characterised by impairments in social interaction, verbal and nonverbal communication, and a restricted repertoire of activities and interests. As it is a condition which persists in one's entire life, maintaining a good Quality of Life (QoL) in such children is essential. The objective of the study was to assess the QoL in 8 to12- year- old children diagnosed with ASD who are attending autism clinics in two major hospitals in Colombo District, Sri Lanka. Methods : A descriptive study was carried out among the caregivers of 8 to12- year-old children with ASD attending two major hospitals in Colombo. Paediatric Quality of Life Inventory (PedsQL) was used to assess the QoL in the children, according to the perception of the caregivers. Results : Thirty-five caregivers were included in the study. Majority of the caregivers were mothers. Mean (SD) age of the children studied was 9.6 (±1.6) years. The median total score was 64.44. The median physical functioning, median emotional functioning, the median social functioning and the median social functioning scores were 81.25, 65.0, 40.0 and 35.0 respectively. The median psychosocial functioning score derived by combined scores of emotional, social and school functioning was 48.0, and it was lower than the median physical functioning score. Conclusion : The QoL of this group of children with ASD attending autism clinics in two major hospitals in Colombo district were poor with the psychosocial component being more affected than the physical component.
Reliability assessment of the Texas Instruments phase light modulator

The Digital Micromirror Device (DMD), developed by Texas Instruments (TI), has been in production for over 25 years. It is a Micro-optical-electro-mechanical system (MOEMS) that functions as a spatial light modulator (SLM) by directing millions of points of light into or out of the projection optics path. TI is now developing a new MOEMS device based on the same processes, equipment sets, and design knowledge as the DMD. This new device operates in a piston mode with each mirror moving up and down instead of rotating left and right as the DMD does. By operating in a piston mode, the mirrors can modulate the phase of light and function as a phase light modulator (PLM). This paper focuses on the reliability of the PLM device. TI has a strong foundation for MOEMS reliability resulting in the mature and reliable DMD. Early results from various life tests and environmental tests confirm that PLM reliability is comparable to DMD reliability. The paper will discuss reliability test results and related performance metrics.
Impact of Multimorbidity and Polypharmacy on Clinical Outcomes of Elderly Chinese Patients with Atrial Fibrillation

Background: The co-incidence of multiple morbidities and polypharmacy is common amongst patients with atrial fibrillation (AF); however, data on their impact on clinical outcomes are scarce in Asian cohorts. Objective: To evaluate the impact of multimorbidity and polypharmacy on clinical outcomes and AF management among elderly Chinese patients. Methods: The ChiOTEAF registry is a prospective, multicenter nationwide study conducted from October 2014 to December 2018. Endpoints of interest were the composite outcome of all-cause death/any thromboembolism (TE), all-cause death, cardiovascular death, TE events, major bleeding, as well as AF management. Results: The eligible cohort included 6341 individuals (mean age 74.7 ± 10.7; 39.1% female), of whom 4644 (73.2%) had multimorbidity (defined as two or more chronic diseases), and 2262 (35.7%) were treated with five or more medications. There were 2775 (43.8%) patients on anticoagulant (OAC) use. On multivariate analysis, (i) multimorbidity was associated with a higher odds ratio of the composite outcome (OR: 2.04; 95% CI: 1.49–2.79), all-cause death (OR: 1.82; 95% CI: 1.31–2.54), cardiovascular death (OR: 2.05; 95% CI: 1.13–3.69), any TE (OR: 2.69; 95% CI: 1.29–5.62), and major bleeding (OR: 2.61; 95% CI: 1.25–5.45); (ii) polypharmacy was associated with a lower odds ratio of all-cause death (OR: 0.78; 95% CI: 0.63–0.96). The use of OAC was safe and was associated with a lower odds ratio of the composite outcome and all-cause death in all subgroups of patients. Conclusions: Multimorbidity and polypharmacy were common among elderly AF Chinese patients. Multimorbidity was an independent predictor of adverse clinical outcomes. The use of OAC was safe and significantly improved survival amongst AF patients with multimorbidity and polypharmacy.
The Rationale for the Dual-Targeting Therapy for RSK2 and AKT in Multiple Myeloma

Multiple myeloma (MM) is characterized by remarkable cytogenetic/molecular heterogeneity among patients and intraclonal diversity even in a single patient. We previously demonstrated that PDPK1, the master kinase of series of AGC kinases, is universally active in MM, and plays pivotal roles in cell proliferation and cell survival of myeloma cells regardless of the profiles of cytogenetic and genetic abnormalities. This study investigated the therapeutic efficacy and mechanism of action of dual blockade of two major PDPK1 substrates, RSK2 and AKT, in MM. The combinatory treatment of BI-D1870, an inhibitor for N-terminal kinase domain (NTKD) of RSK2, and ipatasertib, an inhibitor for AKT, showed the additive to synergistic anti-tumor effect on human MM-derived cell lines (HMCLs) with active RSK2-NTKD and AKT, by enhancing apoptotic induction with BIM and BID activation. Moreover, the dual blockade of RSK2 and AKT exerted robust molecular effects on critical gene sets associated with myeloma pathophysiologies, such as those with MYC, mTOR, STK33, ribosomal biogenesis, or cell-extrinsic stimuli of soluble factors, in HMCLs. These results provide the biological and molecular rationales for the dual-targeting strategy for RSK2 and AKT, which may overcome the therapeutic difficulty due to cytogenetic/molecular heterogeneity in MM.
Willingness to Pay for Destination Quality Improvement: Case Study of Baru Beach, Yogyakarta

This study aims to analyze the willingness to pay visitors for the quality improvement of Baru Beach. The respondents of this research are visitors in Baru Beach. This study uses the contingent valuation method (CVM). Accidental techniques were used to collect data from 150 tourists in Baru Beach. This paper found that the average value of willingness to pay (WTP) is IDR15,000 obtained using dichotomous choice. In addition, variables of age, income, education level, frequency of visits, and visitor perceptions were positive to WTP. Distance and marital status have no significant effect.
The Weekend Effect Investigation: Evidence from Indonesia Capital Market

In the weak-form market efficiency, investors cannot obtain profits by trading stocks through a positive price difference. Unfortunately, this perspective is doubtful because of the weekend effect theory. The highest and lowest return exists on Friday and Monday, respectively, based on this theory. For that reason, this study is presented to prove the weekend effect by statistically checking the return based on the trading days with the variance analysis model and the Tukey Honestly Significant Difference Testing. Unlike the other research, this study utilizes the shares' return to prove this effect in the bullish and bearish markets. Data are collected by archival method from the Yahoo Finance website based on the names of shares chosen as the LQ45 members. The workdays and holidays are obtained based on the information from the Indonesian stock exchange. This finding shows that the lowermost return exists on Tuesday for two markets. Separately, the reverse Monday and the middle-week effects exist in the bearish and the bullish. The return change in the bullish period is more significant than that in the bearish. Therefore, this study is helpful for public investors to transact their shares to gain a positive return by utilizing these daily patterns in these two markets.
Research on Mix Proportion of No-fines and Porous Concrete

The no-fines and porous concrete is porous and permeable,and also has proper strength.It is widely used in civil,roadway and environmental protection project,but the way of its mix design and manufacture is different from the way of the common concrete.By the idea of consistensy condition degree,a optimized method of mix design of the no-fines and porous concrete is put forward in this paper after the experimental research.
Performance of Different Echocardiographic Measurements of Left Atrial Size in Dogs by Observers with Different Levels of Experience

Simple Summary Assessing enlargement of the left atrium (one of the four cardiac chambers) is extremely important for gaining information about dogs’ heart disease, their prognosis, and directing treatment. However, people with different levels of experience may be required to make this assessment, and we don’t know how observers with different experiences perform in making this assessment. In this study, five observers with different levels of experience evaluated the left atrium of 36 dogs in a blinded fashion (i.e., unaware of each other measurements, or of the identity of the dog), compared to two cardiologists. We then used statistical analysis to evaluate repeatability, reproducibility, accuracy of the measurements, and the capacity of correctly identifying left atrial enlargement. We found that the measurements performed by observers with more experience where more similar to the cardiologists’ measurements, and that combining more than one technique for measuring the left atrium can improve accuracy of the identification of left atrial enlargement. Abstract Assessment of left atrial (LA) sizes in dogs informs clinical staging, risk assessment, treatment decisions, and prognosis. The objective of this study was to assess the diagnostic performance of observers with different levels of experience measuring the LA with three different techniques. Echocardiographic images from 36 dogs with different degrees of left atrial enlargement (LAE) were retrospectively retrieved, anonymized and measured in a blinded fashion by a veterinary student, a first-year cardiology resident, a third-year cardiology resident, and two board-certified veterinary cardiologists. The LA to aortic root ratio (LA:Ao), LA antero-postero diameter indexed to body weight (LAiAPD) and left atrial area were measured. Inter- and intra-observer intraclass correlation coefficients (ICCs) were calculated for all three variables. Bland–Altman plots and accuracy in identification of LAE were calculated for the three least experienced observers using LA:Ao and LAiAPD. Intra- and interobserver ICCs were greater than 0.9 for every variable. The observer with least experience had significant positive bias and a tendency to overestimate larger measurements using LA:Ao, but not using LAiAPD. The accuracy of identification of LAE also increased with the increasing level of experience and was higher for LAiAPD compared to LA:Ao. Combining both methods for identification of LAE, further increased accuracy.
TopoCLIM: rapid topography-based downscaling of regional climate model output in complex terrain v1.1

Abstract. This study describes and evaluates a new downscaling scheme that specifically addresses the need for hillslope-scale atmospheric-forcing time series for modelling the local impact of regional climate change projections on the land surface in complex terrain. The method has a global scope in that it does not rely directly on surface observations and is able to generate the full suite of model forcing variables required for hydrological and land surface modelling in hourly time steps. It achieves this by utilizing the previously published TopoSCALE scheme to generate synthetic observations of the current climate at the hillslope scale while accounting for a broad range of surface–atmosphere interactions. These synthetic observations are then used to debias (downscale) CORDEX climate variables using the quantile mapping method. A further temporal disaggregation step produces sub-daily fields. This approach has the advantages of other empirical–statistical methods, including speed of use, while it avoids the need for ground data, which are often limited. It is therefore a suitable method for a wide range of remote regions where ground data is absent, incomplete, or not of sufficient length. The approach is evaluated using a network of high-elevation stations across the Swiss Alps, and a test application in which the impacts of climate change on Alpine snow cover are modelled.
A Survey on Recent Trends, Process and Development in Data Masking for Testing

In today’s information age, the data is an important asset of the organization so the security of the data is a vital role in the industry. In order to achieve the above aspect, the data masking is used. The data masking is mainly the data is replaced with realistic but not the original data. The main objective is to make sensitive information is not made available outside of the environment. The data masking is to just provide the copy of the production data in support of the development environment and thus it controls the leakage of the data. Data masking are designed to be repeatable so referential integrity is maintained. We have explored the data masking architecture, techniques with realistic data and order of masking. We hope this paper will help quality analyst in pulling data from production environments into test environment for quality analysis by safe guarding the original information.
Future hydropower operations in the Zambezi River basin: Climate impacts and adaptation capacity

Southern Africa could experience major hydrological changes in coming decades, bringing drastic changes to hydropower. Focusing on four large hydropower dams in the Kafue and Zambezi Rivers (Itezhi‐Tezhi, Kafue Gorge Upper, Kariba, and Cahora Bassa), accounting for over 90% of the installed capacity in the basin, this study analyzed how these dams have altered river flows in the past, and how hydropower generation could be affected by future climate change and water use scenarios based on dynamically downscaled simulations from the Fifth Coupled Model Intercomparison Project for a Representative Concentration Pathway of 8.5 W/m2. Future climate change could affect reservoir levels by decreasing water inflows and by increasing evaporation. Results showed a decrease in median annual water levels for all reservoirs, with largest changes expected at Itezhi‐Tezhi (−1.3 to −3.3 m), followed by Cahora Bassa (−0.8 to −2.8 m), Kariba (−0.2 to −0.9), and Kafue Gorge (0.1–0.2 m). Flows downstream of dams show a consistent negative trend, with mean annual flow changes of −30% to −49% at the furthest downstream gauge. The combined reduction in water levels and flows could result in decreases on average annual hydropower generation and increases in interannual variability; annual generation could decrease by −61% to −28% at Kariba, by −51% to −21% at Itezhi‐Tezhi, by −7% to −39% at Kafue Gorge, and −27% to −9% at Cahora Bassa. Reservoir operation optimization could marginally offset the projected changes in hydropower generation, with largest gains for Kariba (+6%) and Cahora Bassa (+10%). Overall, opportunities to offset losses via operations would probably decrease with the expected drier climate and escalating reduction in river discharge and water availability. Given these negative projections, it is becoming critical to adapt and coordinate reservoir operations to best cope with the expected challenging future in this important river basin.
Analog Read Noise and Quantizer Threshold Estimation From Quanta Image Sensor Bit Density

Estimation of the analog read noise level and quantizer threshold level to within a few hundredths of an electron can be obtained by measuring the output bit density, D, of a single-bit quanta image sensor (1bQIS) as a function of quanta exposure, H. Analysis of the D-H characteristics as a function of read noise and quantizer threshold levels is performed and a procedure for extraction of estimated read noise and quantizer threshold is suggested and demonstrated.
Dynamic Geometry Environment to Enhance High School Students Spatial Skill: A Study Based on Sex and Gender Diversities Perspective

This research is an experimental quantitative approach that aims to determine the impact of sex and gender differences on senior high school students’ spatial ability through the implementation of dynamic geometry environment (DGE). Ninety-six high-school student participants were categorized based on gender and sex diversities. Data were analyzed using a three-way ANOVA statistical test and Tukey Test. This study indicates that sex and gender differences and the interaction between sex and gender differences significantly affect students’ spatial abilities. The male students outperform the females. The undifferentiated students outperform all students with different genders (feminine, masculine, and androgyny).
Junior High School Student’s Literacy of Science Concept: Electricity & Heredity

High Order Thinking Skills (HOTs) is the way of thinking which should have been mastered by students everywhere early for their life skills. This HOTs skill has been internationally assessed since 2000 every three years attended by all OECD members includes Indonesia through Program International for Student Assessment (PISA). Result of PISA of Indonesian students from 2000 until 2018 still have achieved at level 1a of highest level 6 as national average. Considering geographical area located from West to East, it is very important to map students literacy in each area as base-line of creating integrated effort for Junior High School to increase student’s literacy. This descriptive study aims to promote the profile of Junior High School Literacy. About 40 of 9-grade students and two science teachers involved in this study as research subject. Data were obtained through participative observation, test and video typing for classroom activity during two months on the topic of heredity and electricity. Data were analyzed quantitatively and qualitatively as well. Result showed that students literacy still in low category based on national competence assessment. However there is increase of learning outcome proven by pretest (24.46), post test (33.46), and second post test (59.82). Looking into class level in detail based on daily assessment on the topic of electricity and heredity percentage of students literacy can be categorized as scientific comprehension (57%), higher than partial comprehension (19%) and naïve or wrong comprehension (24%). Student scientific comprehension promoted close to PISA literacy competencies includes explaining phenomena scientifically, evaluating and designing scientific enquiry, interpreting data and evidence scientifically. The study imply the important of keep improving daily science classroom activity which promote students higher order thinking skills in order to achieve better scientific literacy.
Theory Roulette: Choosing that Climate Change is not a Tragedy of the Commons

Climate change mitigation has become a paradigm case both for externalities in general and for the game-theoretic model of the Tragedy of the Commons (ToC) in particular. This situation is worrying, as we have reasons to suspect that some models in the social sciences are apt to be performative to the extent that they can become self-fulfilling prophecies. Framing climate change mitigation as a hardly solvable coordination problem may force us into a worse situation, by changing real-world behaviour to fit our model, rather than the other way around. But while this problem of the performativity of the ToC has been noted in a recent paper in this journal by Matthew Kopec, his proposed strategies for dealing with their self-fulfilling nature fall short of providing an adequate solution. Instead of relying on the idea that modelling assumptions are always strictly speaking false, this paper shows that the problem may be better framed as a problem of underdetermination between competing explanations. Our goal here is to provide a framework for choosing between this set of competing models that allows us to avoid a ‘Russian Roulette’-like situation in which we gamble with existential risk.
A Simple Three Branch Optical Power Splitter Design based on III-Nitride Semiconductor for Optical Telecommunication

We propose a simple design of 1×3 optical power splitter which uses gallium nitride (GaN) on sapphire. The design consists of widely used large cross section input rib waveguide, a rectangular multimode interference (MMI) structure, and three-branch rib waveguides. The MMI structure is selected since their attractive performances, such as compactness, low excess loss, wide bandwidth and ease to fabricate. The power splitter is designed for the third telecommunication window, i.e.,  = 1.55 μm. Optimization of the geometrical structure parameters for the design is conducted theoretically utilizing 3D FD-BPM method. It is found that the power splitter exhibits excess loss of 0.46 dB and imbalanced of 0.001 dB at  = 1.55 μm for = 2.279 and =2.316 , respectively. It means that there is a potential application of the proposed GaN based power splitter structure in the future.
Effect of Pseudomonas fluorescens and Botanicals against Tikka Leaf Spot Disease (Cercospora arachidicola, Cercospora personatum) of Groundnut (Arachis hypogaea L.)

Groundnut (Arachis hypogaea L.) is an important oilseed crop in India. It is susceptible from many diseases, tikka disease is one of them. Tikka disease is due to Cercospora arachidicola, Cercospora personatum causes much damage to production and pod quality. A survey was conducted during Rabi 2020-21 to know the incidence of Tikka disease of groundnut in farmer’s fields in Visakhapatnam district of Andhra Pradesh. Five villages were selected in the district and in each village two fields were surveyed. The disease incidence ranged from 29 to 50 per cent irrespective of location surveyed. The disease incidence was least in Taruva village (29%) and highest in Alamanda village (50%) during the month of January to March 2021. To manage the disease an investigation was carried out in farmer’s field during Rabi 2020-21 in Taruva village, Devarapalle mandal, Visakhapatnam district of Andhra Pradesh to evaluate the efficacy of Bio-agent viz., Pseudomonas fluorescens (S.T), Botanicals viz., Extract and oil sprays of Neem, Eucalyptus, Clove. Among the treatments the plant height (cm), No. of branches, Root length and Pods per plant at 90 DAS was significantly increased in T3 – S.T with Pseudomonas fluorescens + neem oil (F.S) (42.8 cm), (6.2), (9.72), (28.51) respectively. The Disease incidence (%) at 90 DAS was significantly decreased in treatment T3 - S.T with Pseudomonas fluorescens + neem oil (F.S) (15.5%). The Post parameters i.e., shoot length, Root length, Fresh weight and Dry weight at 90 DAS was significantly increased in T3 – S.T with Pseudomonas fluorescens + neem oil (F.S) (42.76 cm), (13.06 cm), (172 gms), (37.96 gms) respectively as compared to control T0.