Miracle-dz/UniFAR-FTUs huggingface dataset:
Palm Based High-Oleic CookingOil and Extra Virgin Olive OilDiets do not Affect Markers ofInsulin Resistance and GlucoseTolerance in Overweight Adults

Palm Based High-Oleic Cooking Oil and Extra Virgin Olive Oil Diets do not Affect Markers of Insulin Resistance and Glucose Tolerance in Overweight Adults Background: High oleic blended cooking oil (HOBO) is an oil product of blended palm olein and canola oil with monounsaturated oleic acid as dominant fatty acid. This blend has increased the amount of oleic acid to more than 50%, with cold stability which is suitable for cooking usage in temperate countries. However, the effects of HOBO diet in human nutrition have not been studied extensively. Objective: We aimed to compare the effects of HOBO vs. oleic acid-rich extra virgin olive oil (OO) diets on markers of insulin resistance and glucose tolerance in overweight subjects. Design: A single-blind, randomized crossover study with 3 dietary interventions of 6-wk each (3-wk washout in between) was conducted in 32 overweight subjects. The 3 test fats were HOBO, OO and refined, bleached and deodorized coconut oil CO incorporated at two-thirds of 30% kcal fat containing 55% kcal from carbohydrates and 15% kcal from protein. Results: No significant differences (P>0.05) were observed in the effects of the 3 diets on markers of insulin resistance [glucose, c-peptide, insulin, fructosamine, Haemoglobin A1c (HbA1c), homeostasis model assessment of insulin resistance (HOMA-IR), homeostasis model assessment of beta cell function index (HOMA-β), and quantitative insulin sensitivity check index (QUICKI)] and glucose tolerance. Conclusions: HOBO diet did not alter markers of insulin resistance and glucose tolerance in overweight Malaysian adults compared with that of OO and CO diets.
Bibliographic Mapping of Open Access Google Books on Peace and War

The study is an attempt to identify the bibliometric facets of Free Google Books like collection size, authorship patterns, time-series, and publishing bodies on ‘Peace’ and ‘War’. The Google Book archive was searched using two search terms ‘Peace’ and ‘War’ in advanced search mode. The search was executed on free Google books during the month of January 2019. Bibliographical details of all the hits (results) retrieved were collected, tabulated, analyzed and interpreted to reveal results. Google Books retrieved 566 e-books on ‘Peace’ out of these, 173 (30.56%) e-books are available in full view whereas 517 e-books were available on “War” out of these 193 (37.33%) e-books are available in full view. The majority of books published during the 19th century are archived by the Google as these were free from the copyright restrictions. Large numbers of Google Books are written by single authors on War (153, 79.24) as well as on Peace (116, 67.05). However, corporate bodies have also contributed significantly in Peace publications (19, 10.98) as well. All sorts of publishers’ commercial, governmental, non-profit societies and even individual publishers including authors have contributed to publishing activities on Peace and War. A good number of books on Peace (171) and War (174) aren’t reviewed by users and till date, only 21 books have been reviewed by users. Among the reviewed books, almost 50% of the books on Peace and War have received 5-star ranking.
Valproate in the Treatment of Acute Mania

Objective: To determine whether valproate is effective for the acute treatment of mania. Data Sources: Pertinent literature was identified through a MEDLINE search. Study Selection: Blinded, controlled, or other high-quality trials with adequate sample size evaluating valproate in the treatment of acute mania were selected. Data Extraction: Study selection for the review was based on the quality of the trial and the clinical endpoint of control of acute manic symptoms using valproate. Data Synthesis: Acute manic episodes in bipolar disease are disabling and dangerous. A minority of acutely manic patients either do not respond to treatment with lithium or cannot tolerate its adverse effects. Valproate is a viable but slightly less effective alternative in the patients who cannot use lithium. Conclusions: Combined analysis of all studies examined in this article yields a success rate of 54% for valproate in the treatment of acute mania. This efficacy rate recommends valproate as suitable alternative treatment for acutely manic patients who do not respond to lithium or cannot tolerate its adverse effects.
Comparative meta-analyses of brain structural and functional abnormalities during cognitive control in attention-deficit/hyperactivity disorder and autism spectrum disorder

Abstract Background People with attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) have abnormalities in frontal, temporal, parietal and striato-thalamic networks. It is unclear to what extent these abnormalities are distinctive or shared. This comparative meta-analysis aimed to identify the most consistent disorder-differentiating and shared structural and functional abnormalities. Methods Systematic literature search was conducted for whole-brain voxel-based morphometry (VBM) and functional magnetic resonance imaging (fMRI) studies of cognitive control comparing people with ASD or ADHD with typically developing controls. Regional gray matter volume (GMV) and fMRI abnormalities during cognitive control were compared in the overall sample and in age-, sex- and IQ-matched subgroups with seed-based d mapping meta-analytic methods. Results Eighty-six independent VBM (1533 ADHD and 1295 controls; 1445 ASD and 1477 controls) and 60 fMRI datasets (1001 ADHD and 1004 controls; 335 ASD and 353 controls) were identified. The VBM meta-analyses revealed ADHD-differentiating decreased ventromedial orbitofrontal (z = 2.22, p < 0.0001) but ASD-differentiating increased bilateral temporal and right dorsolateral prefrontal GMV (zs ⩾ 1.64, ps ⩽ 0.002). The fMRI meta-analyses of cognitive control revealed ASD-differentiating medial prefrontal underactivation but overactivation in bilateral ventrolateral prefrontal cortices and precuneus (zs ⩾ 1.04, ps ⩽ 0.003). During motor response inhibition specifically, ADHD relative to ASD showed right inferior fronto-striatal underactivation (zs ⩾ 1.14, ps ⩽ 0.003) but shared right anterior insula underactivation. Conclusions People with ADHD and ASD have mostly distinct structural abnormalities, with enlarged fronto-temporal GMV in ASD and reduced orbitofrontal GMV in ADHD; and mostly distinct functional abnormalities, which were more pronounced in ASD.
Proceedings of the Comprehensive Oncology Network Evaluating Rare CNS Tumors (NCI-CONNECT) Oligodendroglioma Workshop.

Background Oligodendroglioma is a rare primary central nervous system (CNS) tumor with highly variable outcome and for which therapy is usually not curative. At present, little is known regarding the pathways involved with progression of oligodendrogliomas or optimal biomarkers for stratifying risk. Developing new therapies for this rare cancer is especially challenging. To overcome these challenges, the neuro-oncology community must be particularly innovative, seeking multi-institutional and international collaborations, and establishing partnerships with patients and advocacy groups thereby ensuring that each patient enrolled in a study is as informative as possible. Methods The mission of the National Cancer Institute's NCI-CONNECT program is to address the challenges and unmet needs in rare CNS cancer research and treatment by connecting patients, health care providers, researchers, and advocacy organizations to work in partnership. On November 19, 2018, the program convened a workshop on oligodendroglioma, one of the 12 rare CNS cancers included in its initial portfolio. The purpose of this workshop was to discuss scientific progress and regulatory challenges in oligodendroglioma research and develop a call to action to advance research and treatment for this cancer. Results The recommendations of the workshop include a multifaceted and interrelated approach covering: biology and preclinical models, data sharing and advanced molecular diagnosis and imaging; clinical trial design; and patient outreach and engagement. Conclusions The NCI-CONNECT program is well positioned to address challenges in oligodendroglioma care and research in collaboration with other stakeholders and is developing a list of action items for future initiatives.
Human resource management motivational strategies for enhancing business educators’ job performance in tertiary institutions in Edo and Delta states, Nigeria

The study assessed human resource management strategies for enhancing employees’ motivation in Edo State. Four research questions guided the study. The study size was 182 business educators in tertiary institutions in Edo and Delta States. The descriptive survey design was used for this study. The instrument used was validated by three experts. Pearson’s Product Moment Correlation coefficient was used to compute reliability of the instrument which yielded a correlation coefficient of 0.71. Data collected were analyzed using descriptive statistics. Means were used to answer all the research questions. From the results of the analysis, it was discovered that employers empowered their employees to very low extent; employers rewarded their employees to high extent; employers redesigned employees’ jobs to low extent, and employers created flexible jobs for their employees to low extent respectively. Consequently, it was recommended that workers should be sufficiently empowered to enhance higher performance and more productive. This will also go a long way to reduce attrition rate, the use of verbal praise, allowing workers’ personal development should be given priority attention by management to enhance higher productivity, management should redesign tasks/jobs from time to time so as to enhance motivation, job satisfaction, commitment to reduce absenteeism and turnover, among others.
Treatment of relapsed or refractory non-hodgkin lymphoma with the oral isotype-selective histone deacetylase inhibitor MGCD0103: Interim results from a phase II study

8528 Background: MGCD0103 is an orally available selective inhibitor of histone deacetylases (HDACs) with significant biological activity in preclinical models of both solid tumors and hematopoietic cancers. Methods: Open-label, Phase II trial in adults (Trial 008) with relapsed or refractory diffuse large B-cell lymphoma (DLBCL) or follicular lymphoma (FL). Eligibility included: ≥1 site of measurable disease (≥2.0 cm), ECOG 0 or 1. MGCD0103 was given 3x/week starting at 110 mg; after 32 patients (pts) the starting dose was reduced to 85 mg. Tumor responses were determined every 2 cycles. PK was evaluated on Day 1, Cycle 1. Results: 50 pts received treatment; 33 DLBCL and 17 FL (median age [range], 61.5 years [32−80]; male, n=27; prior rituximab therapy: 96%; prior stem cell transplant: 33%). The response rate in pts with DLBCL met the protocol defined criteria for expansion beyond 21 pts, and enrollment of this cohort is now complete. Of 17 DLBCL pts with tumor reassessed by CT, most had tumor reduction,.
ChiS is a noncanonical DNA-binding hybrid sensor kinase that directly regulates the chitin utilization program in Vibrio cholerae

Significance From bacteria to humans, the ability to properly respond to environmental cues is critical for survival. The cholera pathogen Vibrio cholerae uses one protein, ChiS, to sense chitin in its environmental reservoir to regulate the expression of genes that are critical for the survival and evolution of this pathogen in this niche. Here, we study how the chitin sensor ChiS works, and discover that it regulates gene expression in an unexpected and unorthodox manner. Thus, this study uncovers how the major regulator ChiS works in this important human pathogen and highlights the versatile mechanisms that living systems use to respond to their environment. Two-component signal transduction systems (TCSs) represent a major mechanism that bacteria use to sense and respond to their environment. Prototypical TCSs are composed of a membrane-embedded histidine kinase, which senses an environmental stimulus and subsequently phosphorylates a cognate partner protein called a response regulator that regulates gene expression in a phosphorylation-dependent manner. Vibrio cholerae uses the hybrid histidine kinase ChiS to activate the expression of the chitin utilization program, which is critical for the survival of this facultative pathogen in its aquatic reservoir. A cognate response regulator for ChiS has not been identified and the mechanism of ChiS-dependent signal transduction remains unclear. Here, we show that ChiS is a noncanonical membrane-embedded one-component system that can both sense chitin and directly regulate gene expression via a cryptic DNA binding domain. Unlike prototypical TCSs, we find that ChiS DNA binding is diminished, rather than stimulated, by phosphorylation. Finally, we provide evidence that ChiS likely activates gene expression by directly recruiting RNA polymerase. This work addresses the mechanism of action for a major transcription factor in V. cholerae and highlights the versatility of signal transduction systems in bacterial species.
Implementing problem based learning for first MBBS students in biochemistry

To understand the perception of students and teachers about implementation of Problem Based Learning (PBL) in Biochemistry and to assess its cognitive impact on student. 100 students from I st MBBS participated in the study. PBL was conducted in two sessions with pre validated case designed on hyperlipidemia. Marks scored in pre & post tests were compared by applying students paired‘t’ test. An attitude survey of the student and teachers was done using Likert Scale ranging from strongly disagree to strongly agree. Score of post-test was significantly increased (p<0.001 ). Both teachers and students have favoured PBL as the best method of teaching as it would assist them in seeing relevance of learning to their future role in the community. Both the groups appreciated PBL as it stimulates the learner for self-study, facilitate better and healthy teacher student relationship improves communication skills and problem solving ability in Biochemistry. Student felt that PBL should be made mandatory in biochemistry and suggested other topics as well. However teachers agreed that PBL is time consuming and it would deprive students to acquire knowledge from experienced and good teachers. Teachers and students differ in opinion about nature of the case and active involvement of facilitators. PBL motivates student for self-study and helps to improve communication skills. However guidance of experienced teacher is needed to summarize the topic. Though time consuming PBL should be made mandatory in Biochemistry as a teaching learning tool . Keywords: PBL, Hyperlipidemia, First MBBS
REM Sleep-active Pedunculopontine Tegmental Neurons Supresses REM Sleep Expression and Respiratory Network Activity

The mechanisms underlying the generation of rapid eye movement (REM) sleep are poorly understood. Despite a lack of direct support, neurons maximally active during REM sleep (REM sleep-active) located in the pedunculopontine tegmental nucleus (PPTn) are hypothesized to generate this state and its component phenomenology. This hypothesis has never been directly tested, since the results of selectively inhibiting this cell-group have never been determined. Using microdialysis, electrophysiology, histochemical and pharmacological methods in freelybehaving rats (n=22) instrumented for sleep-wake state and respiratory muscle recordings, I selectively inhibited REM sleep-active PPTn neurons. Contrary to the prevailing hypothesis, I showed that REM sleep-active PPTn neurons suppress REM sleep by limiting the frequency of its onset. These neurons also shape the impact of REM sleep on breathing. REM sleep-active PPTn neurons restrain behavioural activation of upper-airway musculature during REM sleep, while depressing breathing rate and respiratory activation of the upper-airway musculature across
Sea Level Rise in New Zealand: The Effect of Vertical Land Motion on Century‐Long Tide Gauge Records in a Tectonically Active Region

Historically tide gauge (TG) data have been used to estimate global sea level rise. Critical to the analysis of TG records is the assumption that the TG sites are stable and not affected by vertical land motion (VLM). We analyze century‐long TG records from New Zealand that have been affected by VLM due to both major and transient earthquake events at a regional level as well as local instabilities. Using combined GPS and precise leveling, we estimate relative VLM between the GPS and TG of up to 1 mm/year. Based on 15–20 years of GPS data, the effect of seismic activity and slow slip events has uplifted sites by up to 0.8 mm/year on average in Wellington and Dunedin. Updated estimates of long‐term relative sea level (RSL) at four New Zealand TGs, as well as an estimate of RSL at a new fifth TG (New Plymouth), are determined using data through 2013—an additional 13 years compared to the previous study. The VLM corrected RSL rates gives our best estimate absolute sea level of +1.45 ± 0.28 mm/year (1891−2013). It is important that absolute sea level derived from RSL rates include realistic estimates of VLM, especially at TG sites that are close to plate boundaries, located in seismically active regions, affected by glacial isostatic adjustment, land ice loss, or gas/oil/water extraction.
Diagnosis pressure and false positives: Toward a non-reductionist, polytomic approach of child mental problems

ABSTRACT This paper discusses diagnosis pressure and false positives in child mental health care. Diagnosis pressure is the pressure to give a diagnosis even though the criteria for the diagnosis are not all satisfied. Such pressure may be exerted by clients, their context, or professionals. False positives are incorrectly assigned as mental disorders. The paper discusses prevalence of diagnosis pressure and false positives, some of their causes, and advantages and disadvantages of “getting” a diagnosis. Two relevant issues are discussed, namely, categorical versus dimensional approaches of mental disorders and the mind–body relation. Instead of mental health models that are based on a disorder–no disorder dichotomy or that reduce mental problems to either the brain or society, a polytomic (multifaceted) approach is proposed in which all people with mental problems, light or severe, have a place and can get the support they need. It is argued that Daniel Dennett’s view of the relation between body and mind is fruitful such that mental-health problems can be explained at different levels of abstraction: physical, functional, intentional, and/or moral. The Network Approach is briefly discussed as a promising application of what is proposed in the article.
Immunological aspects of intratumoral chemotherapy and immunotherapy in malignant brain tumors

Advances in surgery, chemo- and radiotherapy have only modestly improved survival rates of malignant brain tumor patients during the last decades. Emerging evidence suggests that an efficient treatment of malignant brain tumors will likely require the management of multiple aspects of tumor pathobiology in order to manipulate features as tumor heterogeneity and tumor immunosuppression. Immunotherapy based on peripheral vaccination of autologous tumor cells target both dividing and non-dividing tumor cells and lead to immunological memory. Moreover, intratumoral administration of chemotherapeutic drugs, also referred to as convection-enhanced delivery (CED), is a technique used to circumvent the blood-brain barrier (BBB) and increase the drug distribution within the tumor, while reducing the systemic side effects associated with systemically delivered chemotherapeutic drugs.In this doctoral thesis, I propose intratumoral delivery of cytostatic drugs and immunotherapy as combined tools to treat malignant brain tumors. Thus, the treatment efficacy and the immune-related mechanisms of CED of clinically relevant cytostatic drugs and immunotherapy were investigated in glioma mouse models. CED of temozolomide (CED-TMZ) cured GL261-bearing mice and acted synergistically with wildtype cell immunizations. In addition, CED- TMZ was more effective and less toxic than single intratumoral injections of TMZ in the GL261 model. CED-TMZ prolonged survival in KR158-bearing mice but cure was only achieved with immunotherapy as a monotherapy and in combination with CED-TMZ. The immune dependence of the therapeutic effect of CED-TMZ was confirmed in immunocompromised mice bearing GL261. Infiltration of CD8+ and CD4+ T cells was increased in both models after CED-TMZ and immunization. CED of cisplatin (CED-CIS) induced cure in the GL261 model. As for CED-TMZ, the effect of CED-CIS was abrogated in immunocompromised mice. However, cell immunizations did not have any additive effect with CED-CIS. CED of mitoxantrone cured both GL261- and SB28-bearing mice. In addition, plasma samples from pediatric brain tumor patients were immune-profiled using cytokine multiplex arrays. We identified two patient groups with distinct preoperative inflammatory cytokine profiles that could be used as peripheral biomarkers to help design, predict or monitor the response of immunotherapy.Altogether, these results have important implications for the future development and implementation of locally administered cytostatic drugs and immunotherapy against malignant brain tumors.
QUANTIFICATION OF THE MICROPOROSITY EFFECT ON PERMEABILITY OF POROUS ROCKS

QUANTIFICATION OF THE MICROPOROSITY EFFECT ON PERMEABILITY OF POROUS ROCKS Ismeli Alfonso,1,∗ Mohamed Abatal,2 Iván Castro,2 Alberto Beltrán,1 Alejandra Fuentes,3 & Armando García3 1Instituto de Investigaciones en Materiales, Unidad Morelia, Universidad Nacional Autónoma de México, Campus Morelia UNAM, Antigua Carretera a Pátzcuaro No. 8701, Col. Ex-Hacienda de San José de la Huerta, C.P. 58190, Morelia, Michoacán, México 2Facultad de Ingeniería, Universidad Autónoma del Carmen, Campus III, Avenida Central S/N, Esq. con Fracc. Mundo Maya, C.P. 24115, Ciudad del Carmen, Campeche, México 3Tecnología Aplicada en Exploración y Producción Petrolera, S.A. de C.V. (TEMPLE) Calle 33 Num. 145 2do, Piso Depto, “F,” Col. Burócratas, C.P. 24160, Cd. del Carmen, Campeche, México
An exploration of nurses' understanding of parenting in hospital : a thesis presented in partial fulfilment of the requirements for the degree of Master of Philosophy (Nursing) at Massey University

Parental involvement in their child's care in hospital is common place. Research indicates that parents want to actively participate in the care of their child. Nurses' responses to parental presence in hospital have been examined in previous research, especially with regard to attitudes, perspectives and role division. There was however a gap in the literature with regard to nurses' understanding of parenting in hospital. Within New Zealand there was no research examining nurses' understanding of parenting. The research described in this 75 point thesis explored the nurses' understanding of parenting in hospital. Using focus groups as the research method, eight nurses were invited to share their understanding of parenting in a New Zealand hospital. The data was analysed using thematic analysis informed by Stevens (1996) . Although the size of the study was limited, this research has been able to raise some important issues about nurses' understanding of parenting in hospital, including the conflict perceived between parents and nurses, and the participants "ideal" parent-nurse relationship.