Miracle-dz/UniFAR-FTUs huggingface dataset:
The effect of controlled electrical stimulation (ES) on some of biochemical characteristics and wounds healing in induced diabetic rabbits.

The current experiment was aimed to explore the effect of electrical stimulation (ES) on glucose concentrations, cholesterol levels and triglyceride levels in blood and its effect on wound healing in intact and induced diabetes rabbits. 40th male rabbit divided to five treatment, T1 intact animal as control (positive control), T2 intact animal treated with (ES), T3 diabetic rabbits treated with (ES), T4 diabetic rabbit treated with insulin and T5 diabetic rabbits with no treatment as a negative control. Three sub groups were designed as well, T2*, T3*, T4* each one of them is the same main group but with artificial wound on some of its animals. the results were shown a significant decreasing p<0.05 in blood glucose concentration in T3 in comparison with T4 and T5. The cholesterol levels increased significantly p<0.05 in T4 in compared with T3. The concentrations of triglycerides recorded significant p<0.05 decreasing T3, T4 and T5 in compared with T1 and T2. In another hand the ES had a very obvious effect on wound healing in both T2* (intact animals) and T3* (diabetes animals) in comparison with T4* (insulin treated diabetes animals).
Quantifying the transboundary contribution of nitrogen oxides to UK air quality

Nitrogen dioxide (NO2) pollution is an important contributor to poor air quality (AQ) and a significant cause of premature deaths in the UK. Although transboundary (i.e., international) transport of pollution to the UK is believed to have an impact on UK pollutant concentrations, large uncertainties remain in these estimates. Therefore, the extent to which emission reductions in neighbouring countries would benefit UK AQ relative to local emission reductions also remains unknown. We have used a back‐trajectory model in conjunction with synoptic scale classifications of UK circulation patterns (Lamb Weather Types [LWT]), to quantify the accumulation of nitrogen oxide (NO x = NO2 + NO) emissions in air masses en‐route to the UK. This novel method presents a computationally inexpensive and useful method of quantifying the accumulation of pollutants under different circulation patterns. We find the highest accumulated NO x totals occur under south‐easterly and southerly flows (>15 μg⋅m−2), with a substantial contribution from outwith the UK (>25%). In contrast, the total accumulated NO x under northerly and westerly flows is lower (∼10 μg⋅m−2), and dominated by UK emissions (>95%). This indicates that European emissions can contribute substantially to UK local‐scale pollution in urban areas under south‐easterly and southerly flows. The sensitivity of integrated NO x emission totals under different air masses is investigated by modelling future European emission contributions based on emission reduction targets. Under targets set by the European Union, there would be a decrease in accumulated NO x emissions in London under most wind directions except for north‐westerly, westerly and northerly flow. The largest benefits to UK AQ from transboundary contributions occur with emission reductions in the Benelux region, due to its close proximity and high NO x emission rates, emphasising the importance of international cooperation in improving local AQ.
Development and Preclinical Testing of Laser-Generated Shockwave Therapy for Infected Wounds

The goal of this thesis is to translate laser-generated shockwave (LGS) therapy from a bench- top, research system into a portable, clinical system for in vivo animal trials. Prior research along this topic was completed using a benchtop system, in a physical setup dissimilar to the clinical setup. So the technology required re-engineering in order to apply it to animal studies. This began with the construction of a portable LGS therapy system, mobile enough to transport from laboratory to clinical settings. Included in the portable system is a 2D scanning system to consistently treat wound areas of varying geometries with shockwaves of 3 mm diameter spot sizes. The shockwaves generated by the portable laser system were characterized, along with the varying shockwave-generating substrates possible for clinical application. A final material selection of black polyimide was chosen because of its complete absorption of laser light and its ability to conform to tight wound geometries.Since shockwaves have never been demonstrated to delaminate biofilm from a tissue surface, a proof-of-concept study was completed successfully delaminating Staphylococcus epidermidis from wounded ex vivo pigskin. Through false-colored SEM imaging, biofilm area reduction between treated and non-treated samples were calculated. A 53% reduction in biofilm area and signifcant biofilm fragmentation was seen. An in vivo safety study was conducted next to observe potential physiological effects of LGS on healthy dermal tissue. Treated subjects were observed over a 3 day period, and no physiological or inflammatory effects were seen in the histological analysis. Finally, a pilot wound healing study was com- pleted on excisional wound healing model in rats, with S. epidermidis as the infectious agent, to measure the effect of LGS on wound healing area and rate compared to other treatments. After 9 days of wound healing, no treatment or controls showed a significant difference in wound healing rate or wound area. As a result, LGS also showed no deleterious effects on the tissue which would hinder wound healing. With these results, LGS therapy shows promise as an alternative infected wound treatment, and a system capable of completing thorough animal trials is available for future researchers.
PENGARUH BEBAN KERJA, KETIDAKPUASAN KERJA, DAN KOMPENSASI TERHADAP TURNOVER INTENTION (Studi pada Karyawan Bagian Marketing Mataram Sakti Kebumen)

This study aims to determine the effect of workload, job dissatisfaction, and compensation for turnover intention. The subject of this study was the marketing staff of Mataram Sakti Kebumen. This study was conducted on 37 respondents. The sampling technique used in this study is saturated sampling. The analysis used is statistical analysis with multiple linear regression tests. The results of this study indicate that partially the workload has a positive and significant effect on turnover intention. Job dissatisfaction has a positive and significant effect on turnover intention. Compensation has a negative and significant effect on turnover intention. While simultaneous workload, job dissatisfaction, and compensation have an effect on turnover intention.
Phase Diagram of Methylammonium/Formamidinium Lead Iodide Perovskite Solid Solutions from Temperature-Dependent Photoluminescence and Raman Spectroscopies

The complete phase diagram of organic-cation solid solutions of lead iodide perovskites [FAxMA1–xPbI3, where MA stands for methylammonium, CH3NH3, and FA for formamidinium, CH(NH2)2] with compositi.
Best Practices of the Social Innovations in the Framework of the E-Government Evolution

The social innovations have been together with the advanced technology in the 21st century, taking an essential role in social structures and their informatization processes. Information technology has become an indispensable factor not only in industry and service businesses, but also in governing systems at the micro (cities and regions) and macro (state and nations) levels. The information processes, which includes automation, have in the last few years an important impact on the transformation from “classical” governance into the “smart governance”. In the paper are presented the best practices which show how could social innovations, together with the advanced technology also lead to the several democratic changes in the urban environment. It can be concluded that it will in many ways reorganize public decision – makings, create changes in democratic processes that are in accordance with socioeconomic and technological development, and will represent the basis for the emergence of the so-called the smartest social community and the ensuing novel processes of organization and operation.
Correlation of urinary incontinence in postpartum with the conditions maternal and neonatal

Study design, materials and methods A retrospective cohort study mediated by a structured interview. We selected 1574 records of births in 2011, 51 of these were not included and from 1,523 remained, 858 were vaginal and 665 cesarean births. 246 of them were contacted after 12 months postpartum, being 149 vaginal and 97 post-cesarean births. For statistical analysis, was used the average, average deviation, Mann-Whitney and t-test, linear regression and the χ2 test.
Efficacy of Mastocheck for Screening of Early Breast Cancer: Comparison with Screening Mammography

Purpose: This study was designed to verify the effectiveness of Mastocheck, a new diagnostic tool developed with proteomics techniques using plasma proteins. In addition, checked the current state of mammography used for breast cancer screening. Methods: A total of 305 cases were analyzed (normal 122, breast cancer 183) and used for validation after Mastocheck development. First, screening mammograms of normal patients and pre-diagnosis mammography of cancer patients were reviewed retrospectively. The results were compared with Mastocheck, a newly developed blood test. Imaging tests were blinded and analyzed by dividing the readings of breast specialists and non-breast specialists among radiologists. We confirmed how much better the results would be if only the mammography was used and if both tests were used together. Results: The sensitivity, specificity, and accuracy of mammography alone, reviewed by non-breast specialists among radiologists, were 63.0%, 85.7%, and 71.3%, respectively. In dense breasts, the values were 59.2%, 84.8% and 69.0%, which were too low to be considered interpretable. The sensitivity, specificity and accuracy of the test was 93.9%, 83.8%, and 90.2% when using mammography and Mastocheck together. From these results, an improvement in sensitivity of about 30% and an improvement in accuracy of about 15% or more in concomitant use than mammography alone can be seen. Conclusion: Mastocheck can be widely used for screening breast cancer, especially in dense breasts, patients with low accuracy in mammography, and patients with mammography side effects. In addition, it has the advantage of increasing the diagnosis rate when used with mammography, the current screening method of choice.
Prevalence of KRAS, BRAF, NRAS, PIK3CA, and PTEN alterations in colorectal cancer: Analysis of a large international cohort of 5,900 patients.

399 Background: Colorectal cancer (CRC) is the third most common cancer worldwide, with metastatic disease accounting for 40 to 50% of newly diagnosed patients. EGFR monoclonal antibodies (Mab), cetuximab and panitumumab, are effective treatment for KRAS wild type CRC. Although mutations in KRAS predict resistance to EGFR Mab therapy, only 80% of CRC patients with KRAS wild-type (WT) status respond to treatment. This study is a retrospective evaluation of genomic alterations in the EGFR pathway such as alterations in KRAS, BRAF, NRAS, PIK3CA and PTEN that may predict lack of response to EGFR Mab therapy in CRC patients. Methods: A large database of 5,900 consecutive CRC patients was analyzed from 2011 onwards for demographics (sex, age, geography, site of tumor) and biomarkers that might correlate with response to EGFR Mab therapy. Comprehensive testing included gene sequencing for KRAS, BRAF, NRAS, PTEN, and PIK3CA (next-generation sequencing, Sanger, pyrosequencing) and immunohistochemistry for PTEN pro.
Ask your doctor whether this product is right for you: a Bayesian joint model for patient drug requests and physician prescriptions

The goal of this research is to study jointly physician prescription decisions and patient drug request behaviours. We have adopted a binary logit model and a multinomial logit model to study patient drug request data with excessive zero requests and a multinomial logit model to capture physician prescription decisions. These models are further joined by a flexible non‐parametric multivariate distribution for their random effects. We also adopt an analytically consistent expression for interaction effects in our non‐linear and joint modelling framework. We apply our model to a unique physician panel data set from the erectile dysfunction category. Our key empirical findings include that the triggering of drug requests by direct‐to‐consumer advertising (DTCA) is complex with category level DTCA reducing patients’ probabilities of making drug requests and drug‐specific DTCA driving drug requests for the drug advertised, patients’ characteristics may play a role in both the influence of DTCA on drug requests and the influence of patients’ requests on physicians’ prescription decisions, patients’ drug requests have a positive effect on physicians’ prescription decisions and patients can be consistent with physicians in choosing a drug based on their diagnosis levels and some unobserved factors, and there are significant correlations between physician level random effects that drive both patients’ drug requests and physicians’ prescription decisions, which validate the joint modelling approach.
Community sequencing on a natural experiment reveals little influence of host species and timing but a strong influence of compartment on the composition of root endophytes in three annual Brassicaceae

The plant family Brassicaceae includes some of the most studied hosts of plant microbiomes, targeting microbial diversity, community assembly rules, and effects on host performance. Compared to bacteria, eukaryotes in the brassicaceous microbiome remain understudied, especially under natural settings. Here, we assessed the impact of host identity and age on the assembly of fungal and oomycete root communities, using DNA metabarcoding of roots and associated soil of three annual co-habiting Brassicaceae collected at two time points. Our results showed that fungal communities are more diverse and structured than those of oomycetes. In both cases, plant identity and sampling time had little influence on community variation, whereas root/soil compartment had a strong effect by exerting control on the entry of soil microorganisms into the roots. The enrichment in roots of specific fungi suggests a specialization towards the asymptomatic colonization of plant tissues, which could be relevant to host’s fitness and health.
1670: NEUTROPENIC SEPTIC SHOCK OUTCOMES IN CANCER PATIENTS AND THE INFLUENCE OF COLONY-STIMULATING FACTOR

Introduction/Hypothesis: Neutropenia is a common side effect of cancer therapy and imposes a high risk of infectious complication. Literature assessing the impact of neutropenia in critical illness and the survival benefit of granulocyte-colony stimulating factor (G-CSF) has been controversial. Currently, there are no studies examining the outcomes of oncologic septic shock patients with neutropenia following Sepsis-3 criteria. Therefore, we examined outcomes and studied the survival benefit of G-CSF in this population. Methods: Retrospective cohort study of neutropenic and nonneutropenic patients admitted with the diagnosis of septic shock to an oncologic intensive care unit (ICU) between 4/1/2016 and 12/31/2017. We collected demographics, severity of illness scores, resource utilization, and outcomes. Statistical analyses were performed using SPSS v24. Results: During the study period, we admitted 464 septic shock patients, 208 (45%) of whom were neutropenic. There was no difference in age, sex, and body mass index between these two populations. The median admission and max SOFA score were 10 (8.0:12.0) versus 8 (6.0:11.0) (p<0.001) and 13.5 (10.0:16.0) versus 12 (9.0:15.0) (p=0.001) for the neutropenic and nonneutropenic groups respectively. ICU length-of-stay (LOS) was 6 (2.0:13.0) versus 6 (3.0:12.0) days (p=0.894), and hospital LOS was 21 (9.0:38.0) vs. 14 (8.0:24.2) days (p<0.001). There was no difference in the ICU and hospital mortality, or survival at 30 or 90-days (61.5% vs 58.2%, p=0.466; 70.6% vs 68.3%, p=0.590; 37.0% vs 33.6%, p=0.405; 23.6% vs 25.8%, p=0.946, respectively). Hematologic cancer patients with neutropenic septic shock who received G-CSF had a higher 30-day survival rate (43.6% vs 30.3%, p=0.019) Conclusions: The mortality of neutropenic patients versus nonneutropenic patients was not different, even when neutropenic patients had higher illness severity scores at admission. Hematologic neutropenic patients had a higher 30-day survival rate when G-CSF was administered. G-CSF may have a beneficial role in the management of hematologic patients with septic shock and should be investigated further.
The Relationship Between School Administrators’ Leadership Styles, School Culture, and Organizational Image

In this study, the relationships between the leadership styles of school principals, school culture, and organizational image are examined according to the teachers’ perceptions. The study is designed according to a relational survey model, and it consists of 370 teachers working in 20 schools in Selçuklu, Karatay, and Meram districts of Konya, Turkey. The leadership style scale of school principals (LSSSP), the scale for school culture (SSC), and the scale of the organizational image (SOI) were used as data collection tools. Pearson’s correlation, regression, and path analysis were used for analyzing data in addition to descriptive statistics. It was found that school principals manifest transformational leadership characteristics, the perception of school culture by the teachers is strong and the perception of the organizational image by the teachers is medium. It was also found that there are significant relationships between leadership styles, the school culture, and organizational image, along with the leadership style of school principals, which significantly predicted school culture, and school culture, which significantly predicted organizational image. School culture has a mediator effect on both leadership styles and the organizational image. This is due to the realization of the leadership styles that have an important role in developing an organizational image, through school culture. This research offers the presumptions that leadership manifested by the principal creates a positive effect on the members of the organization and contributes to the formation of strong school culture, in addition to leadership and school culture making a positive contribution to the organizational image of the educational institution.
Laminotomy Discectomy Versus Conservative Management for Lumbar Disc Prolapse: Short Term Results

Background & Objectives: Back pain, the ancient curse is now appearing as a modern epidemic. 80% of the population is affected by this symptom at sometime of life. Impairments of the back and spine are ranked as the most frequent cause of limitation of activities in people of all age groups. Lumbar discs are responsible for well over 90% of all organic symptoms attributable to low backache. Here we have done a clinical study, which includes sixty cases of lumbar intervertebral disc prolapse in the age group of 20 to 70 years, irrespective of sex, with clinical symptoms, signs and radiological evidence treated either conservatively or surgically with discectomy in the Department of Orthopaedics at our institute. All cases were followed up and functional results were analysed. The objective was to study the clinical presentation, evaluate outcome of both conservative and surgical management and to compare the results of both modes of treatment. Methods: Out of 60 patients included in the study, 30 were treated conservatively & another 30 underwent laminotomy discectomy in the Department of Orthopaedics at our institute between October 2007 & September 2013. The short-term followup results in patients who were followed up for a minimum of 6 months after treatment were evaluated by using the Japanese Orthopaedic Association scoring system through clinical examination and questionnaire. Results: Prevalence of disc prolapse was in age group of 20 to70 years, while peak incidence was between 30-40 years of age. Incidence of disc prolapse in males was almost twice as much as in females (in our series 65% male cases were noted). 56.67% cases had disc prolapse at L4-L5 level, which being the commonest site of disc prolapse followed by L5-S1 of about 41.67% and 1.67% at L3-L4 level. In the short term follow-up of 6 months, the outcome was good in 90% & excellent in 6.67% of surgically treated patients with 3% complication rate. Conservatively treated group of patients showed 46.67% good, 43.33% fair & 10% poor results. Interpretation & Conclusion: Short term outcome of standard discectomy in our study was favourable and comparable to other studies. With the execution of appropriate selection criteria and appropriate pre & post treatment planning, a good to excellent outcome was seen in nearly 97% in surgical study. In conservatively treated group, 90% patients showed fair to good result. Therefore lumbar discectomy is still a simple, safe & effective treatment with rapid relief for patient while conservative treatment if given to properly selected cases also gives effective results. Patients undergoing surgery for lumbar disc herniation achieved greater improvement in outcome than conservatively treated patients.