Miracle-dz/UniFAR-FTUs huggingface dataset:
Using ‘infodemics’ to understand public awareness and perception of SARS-CoV-2: A longitudinal analysis of online information about COVID-19 incidence and mortality during a major outbreak in Vietnam, July—September 2020

Background Trends in the public perception and awareness of COVID-19 over time are poorly understood. We conducted a longitudinal study to analyze characteristics and trends of online information during a major COVID-19 outbreak in Da Nang province, Vietnam in July-August 2020 to understand public awareness and perceptions during an epidemic. Methods We collected online information on COVID-19 incidence and mortality from online platforms in Vietnam between 1 July and 15 September, 2020, and assessed their trends over time against the epidemic curve. We explored the associations between engagement, sentiment polarity, and other characteristics of online information with different outbreak phases using Poisson regression and multinomial logistic regression analysis. We assessed the frequency of keywords over time, and conducted a semantic analysis of keywords using word segmentation. Results We found a close association between collected online information and the evolution of the COVID-19 situation in Vietnam. Online information generated higher engagements during compared to before the outbreak. There was a close relationship between sentiment polarity and posts’ topics: the emotional tendencies about COVID-19 mortality were significantly more negative, and more neutral or positive about COVID-19 incidence. Online newspaper reported significantly more information in negative or positive sentiment than online forums or social media. Most topics of public concern followed closely the progression of the COVID-19 situation during the outbreak: development of the global pandemic and vaccination; the unfolding outbreak in Vietnam; and the subsiding of the outbreak after two months. Conclusion This study shows how online information can reflect a public health threat in real time, and provides important insights about public awareness and perception during different outbreak phases. Our findings can help public health decision makers in Vietnam and other low and middle income countries with high internet penetration rates to design more effective communication strategies during critical phases of an epidemic.
Changes in gray whale phenology and distribution related to prey variability and ocean biophysics in the northern Bering and eastern Chukchi seas

Changes in gray whale (Eschrichtius robustus) phenology and distribution are related to observed and hypothesized prey availability, bottom water temperature, salinity, sea ice persistence, integrated water column and sediment chlorophyll a, and patterns of wind-driven biophysical forcing in the northern Bering and eastern Chukchi seas. This portion of the Pacific Arctic includes four Distributed Biological Observatory (DBO) sampling regions. In the Bering Strait area, passive acoustic data showed marked declines in gray whale calling activity coincident with unprecedented wintertime sea ice loss there in 2017–2019, although some whales were seen there during DBO cruises in those years. In the northern Bering Sea, sightings during DBO cruises show changes in gray whale distribution coincident with a shrinking field of infaunal amphipods, with a significant decrease in prey abundance (r = -0.314, p<0.05) observed in the DBO 2 region over the 2010–2019 period. In the eastern Chukchi Sea, sightings during broad scale aerial surveys show that gray whale distribution is associated with localized areas of high infaunal crustacean abundance. Although infaunal crustacean prey abundance was unchanged in DBO regions 3, 4 and 5, a mid-decade shift in gray whale distribution corresponded to both: (i) a localized increase in infaunal prey abundance in DBO regions 4 and 5, and (ii) a correlation of whale relative abundance with wind patterns that can influence epi-benthic and pelagic prey availability. Specifically, in the northeastern Chukchi Sea, increased sighting rates (whales/km) associated with an ~110 km (60 nm) offshore shift in distribution was positively correlated with large scale and local wind patterns conducive to increased availability of krill. In the southern Chukchi Sea, gray whale distribution clustered in all years near an amphipod-krill ‘hotspot’ associated with a 50-60m deep trough. We discuss potential impacts of observed and inferred prey shifts on gray whale nutrition in the context of an ongoing unusual gray whale mortality event. To conclude, we use the conceptual Arctic Marine Pulses (AMP) model to frame hypotheses that may guide future research on whales in the Pacific Arctic marine ecosystem.
Socioeconomic position and self-rated health among female and male adolescents: The role of familial determinants in explaining health inequalities. Results of the German KiGGS study

Objective Although health inequalities in adolescence are well documented, the underlying mechanisms remain unclear. Few studies have examined the role of the family in explaining the association between the family’s socioeconomic position and adolescents’ self-rated health. The current study aimed to explore whether the association between socioeconomic position and self-rated health was mediated by familial determinants. Methods Using data from wave 2 of the”German Health Interview and Examination Survey for Children and Adolescents” (KiGGS) (1,838 female and 1,718 male 11- to 17-year-olds), linear regression analyses were conducted to decompose the total effects of income, education, occupational status, socioeconomic position index and adolescents’ subjective social status on self-rated health into direct effects and indirect effects through familial determinants (family cohesion, parental well-being, parental stress, parenting styles, parental obesity, smoking and sporting activity). Results A significant total effect of all socioeconomic position indicators on self-rated health was found, except for income in male adolescents. In female adolescents, more than 70% of the total effects of each socioeconomic position indicator were explained by familial mediators, whereas no significant direct effects remained. The most important mediator was parental well-being, followed by family cohesion, parental smoking and sporting activity. In male adolescents, the associations between income, parental education, the socioeconomic position index and subjective social status were also mediated by familial determinants (family cohesion, parental smoking, obesity and living in a single-mother family). However, a significant direct effect of subjective social status remained. Conclusion The analysis revealed how a family’s position of socioeconomic disadvantage can lead to poorer health in adolescents through different family practices. The family appears to play an important role in explaining health inequalities, particularly in female adolescents. Reducing health inequalities in adolescence requires policy interventions (macro-level), community-based strategies (meso-level) and programs to improve parenting and family functioning (micro-level).
Should you become a leader in online collaborative learning? Impact of assigned leadership on learning behaviors, outcomes, and perceptions

The growing prevalence of collaborative learning spaces in higher education highlights the importance of student leadership for group learning. Thus, leadership assignment as a common practice in online collaborative learning merits special attention. To investigate the impact of assigned leadership and its key characteristics in promoting team learning in the online context, a semester-long quasi-experiment was conducted with 94 students in a graduate-level blended course. The results revealed significant differences between assigned leaders and group members in certain participating behaviors. However, the impact of assigned leadership on learning outcomes and perceptions was insubstantial. Additionally, student leaders’ academic achievement was found to have little impact on group members’ learning behaviors and learning outcomes, and mixed results were reported regarding the influence of leader behaviors on group performance. The research findings can inform the crucial decision of leader selection and extend our understanding of leadership in online collaborative learning.
Comparison of Montreal cognitive assessment and Mattis dementia rating scale in the preoperative evaluation of subthalamic stimulation in Parkinson’s disease

Introduction The preoperative evaluation of Parkinson’s Disease (PD) patients for subthalamic nucleus deep brain stimulation (STN-DBS) includes the assessment of the neuropsychological status of the patient. A widely used preoperative test is the Mattis Dementia rating scale (MDRS). However, the Montreal cognitive assessment (MoCA) has also been proven to be a sensitive, time-sparing tool with high diagnostic validity in PD. We evaluate the utility of the MoCA as a preoperative screening test for PD patients undergoing bilateral STN-DBS. Methods In this single-centre, retrospective study, we analysed pre- and postoperative assessments of MoCA, MDRS, Movement disorder society-Unified PD Rating Scale-motor examination, PD Questionnaire-39 and levodopa equivalent daily dose. Longitudinal outcome changes were analysed using paired t-test, Pearson’s correlation coefficient, linear regression and CHAID (chi-square automatic interaction detector) regression tree model. Results Clinical motor and cognitive scores of 59 patients (61.05±7.73 years, 24 females) were analysed. The MoCA, but not the MDRS, identified significant postoperative cognitive decline in PD patients undergoing STN-DBS. The preoperative MoCA score correlated with postoperative quality of life improvement, whereas the MDRS did not. PD patients with a MoCA score ≤ 23 points had a significant decline of quality of life after DBS surgery compared to patients > 23 points. Conclusion This study identifies the MoCA as an alternative test within the preoperative evaluation of PD patients for the detection of neuropsychological deficits and prediction of the postoperative improvement of quality of life.
Mode of action and human relevance assessment of male CD‐1 mouse renal adenocarcinoma associated with lifetime exposure to empagliflozin

Inhibition of sodium‐glucose cotransporter‐2 (SGLT2) has been shown to be a safe and efficacious approach to support managing Type 2 diabetes. In the 2‐year carcinogenicity study with the SGLT2 inhibitor empagliflozin in CD‐1 mice, an increased incidence of renal tubular adenomas and carcinomas was identified in the male high‐dose group but was not observed in female mice. An integrated review of available nonclinical data was conducted to establish a mode‐of‐action hypothesis for male mouse‐specific tumorigenesis. Five key events were identified through systematic analysis to form the proposed mode‐of‐action: (1) Background kidney pathology in CD‐1 mice sensitizes the strain to (2) pharmacology‐related diuretic effects associated with SGLT2 inhib ition. (3) In male mice, metabolic demand increases with the formation of a sex‐ and species‐specific empagliflozin metabolite. These features converge to (4) deplete oxidative stress handling reserve, driving (5) constitutive cellular proliferation in male CD‐1 mice. The proposed mode of action requires all five key events for empagliflozin to present a carcinogenicity risk in the CD‐1 mouse. Considering that empagliflozin is not genotoxic in the standard battery of genotoxicity tests, and not all five key events are present in the context of female mice, rats, or humans, nor for other osmotic diuretics or other SGLT2 inhibitors, the observed male mouse renal tumors are not considered relevant to humans.
Age effects on radiation response: summary of a recent symposium and future perspectives

Abstract One of the principal uncertainties when estimating population risk of late effects from epidemiological data is that few radiation-exposed cohorts have been followed up to extinction. Therefore, the relative risk model has often been used to estimate radiation-associated risk and to extrapolate risk to the end of life. Epidemiological studies provide evidence that children are generally at higher risk of cancer induction than adults for a given radiation dose. However, the strength of evidence varies by cancer site and questions remain about site-specific age at exposure patterns. For solid cancers, there is a large body of evidence that excess relative risk (ERR) diminishes with increasing age at exposure. This pattern of risk is observed in the Life Span Study (LSS) as well as in other radiation-exposed populations for overall solid cancer incidence and mortality and for most site-specific solid cancers. However, there are some disparities by endpoint in the degree of variation of ERR with exposure age, with some sites (e.g., colon, lung) in the LSS incidence data showing no variation, or even increasing ERR with increasing age at exposure. The pattern of variation of excess absolute risk (EAR) with age at exposure is often similar, with EAR for solid cancers or solid cancer mortality decreasing with increasing age at exposure in the LSS. We shall review the human data from the Japanese LSS cohort, and a variety of other epidemiological data sets, including a review of types of medical diagnostic exposures, also some radiobiological animal data, all bearing on the issue of variations of radiation late-effects risk with age at exposure and with attained age. The paper includes a summary of several oral presentations given in a Symposium on “Age effects on radiation response” as part of the 67th Annual Meeting of the Radiation Research Society, held virtually on 3–6 October 2021.
Health-Related and Behavioral Factors Associated With Lung Cancer Stage at Diagnosis: Observations From Alberta’s Tomorrow Project

Background Lung cancer is the leading cause of cancer death in Canada, with stage at diagnosis among the top predictors of lung cancer survival. Identifying factors associated with stage at diagnosis can help reduce lung cancer morbidity and mortality. This study used data from a prospective cohort study of adults living in Alberta, Canada to examine factors associated with lung cancer stage at diagnosis. Methods This cohort study used data from adults aged 35–69 years enrolled in Alberta’s Tomorrow Project. Partial Proportional Odds models were used to examine associations between sociodemographic characteristics and health-related factors and subsequent lung cancer stage at diagnosis. Results A total of 221 participants (88 males and 133 females) developed lung cancer over the study period. Nearly half (48.0%) of lung cancers were diagnosed at a late stage (stage IV), whereas 30.8 % and 21.3% were diagnosed at stage I/II and III, respectively. History of sunburn in the past year was protective against late-stage lung cancer diagnosis (odds ratio (OR) . 40, P=. 005). In males, a higher number of lifetime prostate specific antigen tests was associated with reduced odds of late-stage lung cancer diagnosis (odds ratio .66, P=.02). Total recreational physical activity was associated with increased odds of late-stage lung cancer diagnosis (OR 1.08, P=.01). Discussion Lung cancer stage at diagnosis remains a crucial determinant of prognosis. This study identified important factors associated with lung cancer stage at diagnosis. Study findings can inform targeted cancer prevention initiatives towards improving early detection of lung cancer and lung cancer survival.
Epitope mapping of neutralising anti‐SARS‐CoV‐2 monoclonal antibodies: Implications for immunotherapy and vaccine design

Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is the causative agent of the coronavirus disease 2019 (COVID‐19) pandemic. This disease has currently affected more than 346 million people and resulted in more than 5.5 million deaths in many countries. Neutralising monoclonal antibodies (MAbs) against the SARS‐CoV‐2 virus could serve as prophylactic/therapeutic agents in COVID‐19 infection by providing passive protection against the virus in individuals. Until now, no Food and Drug Administration/European Medicines Agency‐approved neutralising MAb against SARS‐CoV‐2 virus exists in the market, though a number of MAbs have been authorised for emergency use. Therefore, there is an urgent need for development of efficient anti‐SARS‐CoV‐2 neutralising MAbs for use in the clinic. Moreover, neutralising anti‐SARS‐CoV‐2 MAbs could be used as beneficial tools for designing epitope‐based vaccines against the virus. Given that the target epitope of a MAb is a crucial feature influencing its neutralising potency, target epitopes of neutralising anti‐SARS‐CoV‐2 MAbs already reported in the literature and reactivity of these MAbs with SARS‐CoV‐2 variants are reviewed herein.
Inhibition of PDK1 enhances radiosensitivity and reverses epithelial–mesenchymal transition in nasopharyngeal carcinoma

Radioresistance challenges the clinical outcomes of nasopharyngeal carcinoma (NPC). The 3‐phosphoinositide‐dependent protein kinase 1 (PDK1) is a crucial kinase of PI3K/AKT signaling pathway which has been implicated in the process of radioresistance. However, the role of PDK1 in NPC remains largely unclear.
Protective motivators and precautionary behaviors against COVID-19 in Turkey

Summary In this research, we investigated the protection motivators and precautionary behaviors against coronavirus disease 2019 (COVID-19) and the associations between them. To do this, we developed two original scales, collected data (2783 responses) using an online survey, after removing the responses (319), which were filled in incompletely or incorrectly in the questionnaire, we obtained 2464 participants covering the aged 18+ population in Turkey. Based on random sampling, our sample complies with these ratios and generally reflects the aged 18+ population of Turkey. We confirmed the psychometrical validity and reliability of our two scales using the collected data. Herewith, we found that perceived susceptibility of COVID-19 infection is very high, perceived severity of COVID-19 is medium, COVID-19 related information seeking is high, beliefs on precautions’ efficacy is high and also the practice of precautionary behaviors is high. Our research depicts that all protection motivators significantly are related with the practice of precautionary behaviors (routine and leisure). However, with the only exception of perceived severity of COVID-19 is not related with precautionary behaviors (routine). Besides, we saw that females’ average in all variables is significantly higher than males and some variables are sensitive to age, education level, marital status and the number of children. We believe that the findings provide essential inputs for authorities in establishing public health policies against the present pandemic and likely ones in the future.
Toward nonprobabilistic explanations of learning and decision-making.

Referring to probabilistic concepts (such as randomness, sampling, and probability distributions among others) is commonplace in contemporary explanations of how people learn and make decisions in the face of environmental unknowns. Here, we critically evaluate this practice and argue that such concepts should only play a relatively minor part in psychological explanations. To make this point, we provide a theoretical analysis of what people need to do in order to deal with unknown aspects of a typical decision-making task (a repeated-choice gamble). This analysis reveals that the use of probabilistic concepts in psychological explanations may and often does conceal essential, nonprobabilistic steps that people need to take to attempt to solve the problems that environmental unknowns present. To give these steps a central role, we recast how people solve these problems as a type of hypothesis generation and evaluation, of which using probabilistic concepts to deal with unknowns is one of many possibilities. We also demonstrate some immediate practical consequences of our proposed approach in two experiments. This perspective implies a shift in focus toward nonprobabilistic aspects of psychological explanations. (PsycInfo Database Record (c) 2022 APA, all rights reserved).
Using the Stay Strong App for the Well-being of Indigenous Australian Prisoners: Feasibility Study

Background The gap between mental health needs and resources for Aboriginal and Torres Strait Islander people, the Indigenous people of Australia, is most marked in the prison population. Indigenous people are overrepresented in Australian prisons. In prison, this group experiences mental disorders to a greater degree than non-Indigenous prisoners. This group has also been found to experience mental disorder at a higher rate than Indigenous people in the community. In addition to pre-existing determinants of poor mental health, these high prevalence rates may reflect poor engagement in mainstream interventions or the efficacy of available interventions. In community populations, the use of digital mental health resources may help to increase access to well-being support. However, culturally appropriate digital tools have not been available to Indigenous people in prisons. The absence of feasibility and efficacy studies of these tools needs to be addressed. Objective The aim of this study is to determine the feasibility of the Stay Strong app as a digital well-being and mental health tool for use by Indigenous people in prison. Methods Dual government agency (health and corrective services) precondition requirements of implementation were identified and resolved. This was essential given that the Stay Strong app was to be delivered by an external health agency to Indigenous prisoners. Then, acceptability at a practice level was tested using postuse qualitative interviews with clients and practitioners of the Indigenous Mental Health Intervention Program. All Indigenous Mental Health Intervention Program practitioners (10/37, 27%) and client participants who had completed their second follow-up (review of the Stay Strong app; 27/37, 73%) during the study period were invited to participate. Results Owing to the innovative nature of this project, identifying and resolving the precondition requirements of implementation was challenging but provided support for the implementation of the app in practice. Acceptability of the app by clients and practitioners at a practice level was demonstrated, with nine themes emerging across the interviews: satisfaction with the current Stay Strong app, supported client goal setting, increased client self-insight, improved client empowerment, cultural appropriateness, enhanced engagement, ease of use, problems with using an Android emulator, and recommendations to improve personalization. Conclusions The Stay Strong Custody Project is a pioneering example of digital mental health tools being implemented within Australian prisons. Using the app within high-security prison settings was found to be feasible at both strategic and practice levels. Feedback from both clients and practitioners supported the use of the app as a culturally safe digital mental health and well-being tool for Aboriginal and Torres Strait Islander people in prison.
Delayed medical care and its perceived health impact among US older adults during the COVID‐19 pandemic

Medical care delivery has been substantially disrupted during the coronavirus disease 2019 (COVID‐19) pandemic, leading to delays in medical care, particularly among older adults. Less is known about how these delays have affected different segments of this population. Understanding the negative health consequences older adults face from delayed care will provide critical insights into the longer‐term population health needs following the pandemic.