Miracle-dz/UniFAR-FTUs huggingface dataset:
‘Help from the App Store?’: A Systematic Review of Depression Apps in German App Stores

auf ihren Nutzen für die klinische Praxis beurteilt. Ergebnisse: Von 1156 identifizierten Apps wurden 38 eingeschlossen. Inhaltlich reichten diese von Informations- bis zu Interventions-Apps. Die Apps wiesen eine mittlere Gesamtqualität auf (M = 3,01; Standardabweichung = 0,56). Vier Apps zeigten überdurch-schnittliche Werte. Sie wurden durch 2 Psychotherapeuten getestet und als bedingt empfehlenswert für die klinische Pra xis beurteilt. Zu keiner der eingeschlossenen Apps konnte eine Wirksamkeitsstudie gefunden werden. Schlussfolgerun-gen: Deutschsprachige Depressions-Apps weisen qualitative Mängel auf. Zusätzlich fehlt es an klinischen Studien zum Nutzen und zu Risiken, weshalb der Einsatz in der klinischen Praxis nur bedingt empfohlen werden kann. Ein Gütesiegel für qualitativ hochwertige und praxisrelevante Gesundheits-Apps könnte Nutzer vor Fehlinformationen und Missbrauch schützen und Leistungserbringern den Einsatz digitaler Medi-en substanziell erleichtern. A practicing psychotherapists regarding their practical relevance. Results: 38 out of 1,156 identified depression apps were included in the study. Their content ranged from basic information to specific interventions. The overall quality was average (M = 3.01, standard deviation = 0.56). Four high-quality apps were identified. They were evaluated by 2 psychotherapists and recommended with reserva-tions for practical use. No effectiveness study was found for any app included. Conclusions: Depression apps available in German showed an average quality. There is a general lack of evidence. The identified apps can only be recommended with reservations. A quality seal could help by marking high-quali-ty apps with practically relevant content. Thereby, users could be protected from misinformation and abuse, and therapists would be able to facilitate the use of digital media more easily.
Intracellular Bacteria Responses following Infection with Immunity and Enhances Pathogenic Receptor Limits the Magnitude of Protective The Interaction between IL-18 and IL-18

The binding of IL-18 to IL-18R a induces both proinﬂammatory and protective functions during infection, depending on the context in which it occurs. IL-18 is highly expressed in the liver of wild-type (WT) C57BL/6 mice following lethal infection with highly virulent Ixodes ovatus ehrlichia (IOE), an obligate intracellular bacterium that causes acute fatal toxic shock-like syndrome. In this study, we found that IOE infection of IL-18R a 2 / 2 mice resulted in signiﬁcantly less host cell apoptosis, decreased hepatic leukocyte recruitment, enhanced bacterial clearance, and prolonged survival compared with infected WT mice, suggesting a pathogenic role for IL-18/IL-18R a in Ehrlichia -induced toxic shock. Although lack of IL-18R decreased the magnitude of IFN- g producing type-1 immune response, enhanced resistance of IL-18R a 2 / 2 mice against Ehrlichia correlated with increased proinﬂammatory cytokines at sites of infection, decreased systemic IL-10 production, increased frequency of protective NKT cells producing TNF- a and IFN- g , and decreased frequency of pathogenic TNF- a –producing CD8 + T cells. Adoptive transfer of immune WT CD8 + T cells increased bacterial burden in IL-18R a 2 / 2 mice following IOE infection. Furthermore, rIL-18 treatment of WT mice infected with mildly virulent Ehrlichia muris impaired bacterial clearance and enhanced liver injury. Finally, lack of IL-18R signal reduced dendritic cell maturation and their TNF- a production, suggesting that IL-18 might promote the adaptive pathogenic immune responses against Ehrlichia by inﬂuencing T cell priming functions of dendritic cells. Together, these results suggested that the presence or absence of IL-18R injections (1 m g/mouse) were administered to E. muris -infected mice on days 3–6 p.i. These time points correspond to time points at which a signiﬁcant elevation in IL-18 in the sera and livers of lethally/IOE-infected WT mice was observed. The sham controls con- sisted of E. muris -infected mice injected with PBS only or uninfected mice injected with rIL-18 only at the same time points.
In ammatory and metabolic pro les of patients with end-stage renal disease: potential strategy for predictive, preventive, and personalized medicine

Xiaoxin Ma Shanghai 9th Peoples Hospital A liated to Shanghai Jiaotong University School of Medicine Yongli Wang Shanghai 9th Peoples Hospital A liated to Shanghai Jiaotong University School of Medicine Hongyu Wu Shanghai 9th Peoples Hospital A liated to Shanghai Jiaotong University School of Medicine Fei Li Shanghai 9th Peoples Hospital A liated to Shanghai Jiaotong University School of Medicine Xiping Feng Shanghai 9th Peoples Hospital A liated to Shanghai Jiaotong University School of Medicine Yingxin Xie Shanghai 9th Peoples Hospital A liated to Shanghai Jiaotong University School of Medicine Danshu Xie Shanghai 9th Peoples Hospital A liated to Shanghai Jiaotong University School of Medicine Wenji Wang Shanghai 9th Peoples Hospital A liated to Shanghai Jiaotong University School of Medicine Edward. Chin. Man. Lo University of Hong Kong Haixia Lu (  ritalu0225@hotmail.com ) Shanghai Ninth People's Hospital https://orcid.org/0000-0002-0013-6472
Interactions in Virtual Customer Environments toward Customer Relationship Management: A Study of Tourist Hotels in Sri Lanka

With the introduction of digitalization, virtual customer environments (VCEs) play a significant role in the business world and it has become a strategic indicator for the success of business. Consequently, business entities have established VCEs, which enable customers and firms to virtually interact and build a relationship with each other. This study examines the impact of customer interactions in such VCEs on the nature of customer-business relationships of tourist hotels in Sri Lanka. The study is significant to Sri Lankan context as no studies have been conducted in this field. The study was developed and tested a conceptual model using a scientific quantitative research methodology. According to the results, it was found that customer interactions in VCEs associate the nature of customer-business relationships of the tourist hotels in Sri Lanka while VCE mediates the said association. Thus, VCEs should be an integral element of firms’ CRM strategy in the context of the tourist hotels in Sri Lanka.
Institutional Quality, Macroeconomic Policy and Economic Development in Nigeria

This paper examines the relationship between institutional quality, macroeconomic policy, and economic development in Nigeria. We employ data from four development indicators: the prevalence of undernourishment, life expectancy at birth, the Human Development Index (HDI) and Gross Domestic Product (GDP) per-capita from 1995 to 2013 to examine the validity of the proposed framework. Our result indicates an insignificant impact of domestic institution on Nigeria development indices. Interest rate was also found to have an insignificant impact on economic development in Nigeria, even when growth related indices were considered. On the other hand, government expenditure was found to exert a significant, though small, impact on the country’s development indices. Based on these, a holistic approach of attitudinal change, systematic strengthening and development of institutions is recommended for the attainment of the country`s developmental objectives.
Receptor-type protein tyrosine phosphatase zeta is a functional receptor for interleukin-34*

Background: IL-34 and the known IL-34 receptor, CSF-1R, are differentially expressed in mouse brain, thus IL-34 may signal via an additional receptor(s). Results: IL-34 binds to PTP-ζ on U251 human glioblastoma cells to stimulate intracellular signaling and responses. Conclusion: PTP-ζ is an IL-34 receptor. Significance: CSF-1R-independent actions of IL-34 via PTP-ζ should be considered in evaluating IL-34 roles in development and disease.
A staggered finite volume scheme on general meshes for the generalized Stokes problem in two space dimensions AstaggeredschemefortheStokesequations

This paper presents a new finite volume scheme for the steady Stokes equations on a general 2D mesh. The scheme is staggered, i.e. the discrete velocities are not located at the same place as the discrete pressures. We prove the existence and the uniqueness of a discrete solution. We then prove convergence of the discrete velocities to theweak solution of the problem. Under additional regularity conditions, we prove the convergence of a penalized version of the scheme to the weak solution of the problem. Numerical experiments on problems with known analytical solutions allow to obtain the rate of convergence for both velocities and pressure
The festival motivation and its consequences: the case of the Fethiye International Culture and Art Festival, Turkey

Festivals, as an innovative product, have become increasingly popular at various destinations. Although some researches have been conducted about festivals, few researches have been carried out with the aim of understanding the impacts of festival motivations on visitors’ post-purchase behaviors. Therefore, this study aims to test a model of whether festival motivations impact on the post-purchase behavior of attendees of the Fethiye International Culture and Art Festival in Turkey. Based on the literature, five push and five pull motivation dimensions were determined. An on-site intercept survey was conducted and 388 items of data were gathered from the festival visitors. According to the structural equation model results, there is an interrelationship between festival motivations, satisfaction and word-of-mouth for attendees of a festival. The novelty is the strongest push motivation dimension that affects festival satisfaction, whereas atmosphere is the most effective pull dimension. The results are valuable to festival organizers in order to promote the attendees’ word-of-mouth and thereby increase participation in the festivals, which leads to increased motivation and satisfaction. The practical and theoretical implications of the study results are discussed.
lncRNA LSINCT5 Regulates miR-20a-5p/XIAP to Inhibit the Growth and Metastasis of Osteosarcoma Cells

Background: More and more evidence has shown that non-coding RNA (ncRNA), including long ncRNA (lncRNA) and micro RNA (miRNA), plays a crucial regulatory role in osteosarcoma (OS). Previously, we revealed a Rho-related coiled coil incorporating protein kinase 1(XIAP). A transfer-related gene is negatively regulated by microRNA-20a-5p (miR-20a-5p) and plays the role of oncogene in OS. It is not clear if any lncRNA is involved in the axial upstream of miR-20a-5p/XIAP. Methods: Expression of LSINCT5 and miR-20a-5p/XIAP in OS tissues was determined through qRT-PCR (qP). The proliferation and migration/invasion activity of OS cells were tested through CCK-8/and transwell assay, respectively. The changes on expression of XIAP were examined through qRT-PCR and Western blot (WB). Targeted binding between LSINCT5, miR-20a-5p, and XIAP has been veri ﬁ ed using dual luciferase reporter gene analysis, RNA Immunoprecipitation (RIP), and RNA pull-down experiments. The effect of LSINCT5 on tumor growth was determined by tumor allograft test. Results: In this study, elevated LSINCT5 was found in OS tissue samples and OS cell strains, and the increased LSINCT5 was strongly related to the adverse prognosis of clinical patients. Functional assays showed that inhibition of LSINCT5 could up-regulate miR-20a-5p-mediated OS cells proliferation and metastasis. WB analysis and qP analysis showed that LSINCT5 regulated XIAP by mediating miR-20a-5p. Further cell behavior experiments showed that LSINCT5 acted as a miR-20a-5p sponge to inhibit proliferation and metastasis caused by XIAP. Finally, the results of animal models in vivo showed that LSINCT5 could regulate the tumor growth of OS. Conclusion: LncRNA LSINCT5 acts as an oncogene and promotes XIAP mediated growth and metastasis as competitive endogenous RNA (ceRNA) in OS.
Statistics on wreath products

Well-known statistics on the symmetric group include descents, inversions, major index, and the alternating numbers. This dissertation extends these statistics to two classes of wreath product groups. In both classes we study several different definitions of descent and prove generating functions that rely on these definitions. We also see that equivalent definitions of alternation in the symmetric group lead to different generating functions in the wreath product. We prove our results by applying ring homomorphisms to well-known symmetric function identities and interpreting the resulting expressions combinatorially.
Visualizing Baseball

Visualizing Baseball explores the ability to analyze baseball statistics through graphical meth-ods. It follows two previous books by Jim Albert on the subject of baseball statistics: Curve Ball (Albert and Bennett 2001) and Analyzing Baseball Data with R (Marchi and Albert 2013). It is a little surprising that this subject appears in the ASA-CRC Series on Statistical Reasoning in Science and Society as the subject matter is extremely domain based. The reader is required to have a considerable background knowledge of US Major League Baseball and only a basic knowledge of descriptive statistics. Correspondingly, this book will appeal to baseball fans with an interest in data analysis, but not to statisticians and data scien-tists interested in data visualization, who only occasionally watch the game. As an example, the statistic on base percentage (OBP) is deﬁned using a formula involving ﬁve other unex-plained abbreviations. In cases where a metric is explained using words, the description can be imprecise, albeit clear enough for followers of baseball statistics (e.g., the statistic plate appearances is not exactly what one might at ﬁrst expect). One can argue that this approach is appropriate for a book of this type, but it undoubtedly reduces the potential readership. For those who are in the target audience, the book is interesting, informative and easy to read. The primary aim of the book is well executed. almost all cases the graphics are well thought out, and communicate characteristics convey using very good. Each
and In Vitro Vivo Dinucleotide Induces T Cell Apoptosis In Extracellular Nicotinamide Adenine

Incubation of mouse T cells expressing the cell surface enzyme ADP ribosyltransferase with nicotinamide adenine dinucleotide (NAD) had been reported to cause ADP ribosylation of cell surface molecules, inhibition of transmembrane signaling, and sup-pression of immune responses. In this study, we analyze the reasons for these effects and report that contact of T cells with NAD causes cell death. Naive T cells when incubated with NAD and adoptively transferred into semiallogeneic mice fail to cause graft-vs-host disease, and when injected into syngeneic, T cell-deﬁcient recipients do not reconstitute these mice. Rather, they accumulate in the liver, leading to an increase of apoptotic lymphocytes in this organ. Similar effects are induced by injection of NAD, shown to cause a dramatic increase of apoptotic CD3 (cid:1) , CD4 (cid:1) , and CD8 (cid:1) cells in the liver. Consistent with this, in vitro incubation of naive T cells with NAD is shown to induce apoptosis. In contrast, no cell death is demonstrable when T cells are activated before incubation with NAD. It is concluded that ecto-NAD, as substrate of ADP ribosyltransferase, acts on naive, but not on activated CD69 (cid:1) T cells. The Journal of Immunology, 2001, 167: 4942–4947.
Technology adoption and socio-economic determinants of cashew farming in North Kerala

The present investigation analyses the existing technology utilization status in the Kannur and Kasaragod districts of Kerala state, as a prerequisite for developing and initiating innovative cashew production technology interventions for combating low productivity and profitability from cashew cultivation. An ‘ex-post-facto cause to effect’ design was used, and a rural appraisal ascertained that the levels of technology utilization were significantly low among cashew farmers in this region. The majority of farmers surveyed exhibited a low level of technology utilization status in cashew farming. Four socio-personal variables viz., extension contact, extension participation of cashew farmers, information and communication technologies (ICT) usage and cosmopoliteness and seven economic variables viz. , farm size, area under cashew, number of yielding cashew trees, expenditure in agriculture, net income from agriculture, expenditure in cashew farming and net income from cashew farming were found to have a significant positive contribution towards adoption of cashew production technologies. Stepwise regression yielded a model with four predictors viz . , number of yielding cashew trees, extension participation , net income from agriculture and farm size (negative effect) explaining up to 47.5 per cent of the variation in technology utilization among cashew farmers.
The High Phagocytic Activity of Macrophages against Blood Stream Isolates of Enterococci

The incidence of serious enterococcal infections is increasing while its pathogenesis remains not sufficiently understood. This study aimed to evaluate the resistance of blood strains and commensal isolates of enterococci to phagocytosis in-vitro . Enterococcal strains were isolated from blood of patients hospitalized in Invasive Medicine Centre of the Medical University of Gdańsk and from faeces of healthy volunteers. The strains were cultured in BHI medium in 37ºC for 24h (planktonic form) and 72h (biofilm form cultured in 6-wells culture plates). Bacterial cells were dispersed, stained with fluorescent reporters (SYTO9, PI) and incubated with phagocytes. Macrophage phagocytosis was studied using THP-1 derived macrophages (activation with 6uM PMA). Phagocytosis level was assessed using microscope automated system - Pansy’s 3000 and analysed with Cell Profiler 2.1. 1 software which yielded the number of phagocytosed bacteria per phagocytic cell (load index, LI). Phagocytosis maintained by macrophages was more effective against planktonic cells of blood stream isolates (LI 0,55) than against commensal strains or biofilm released cells (LI 0,29 and 0,19 respectively). The results demonstrated differences in phagocytosis susceptibility of blood stream and commensal enterococcal isolates and proved that the macrophages may eradicate bacterial biofilm. transplantation) patients’ enterococcal isolates include susceptibility to phagocytosis [13]. The current study aimed to compare macrophages’ activity against intestinal and blood stream isolates of enterococci, considering biofilm and planctonic form.
Replication in a Natural Host Species Role for Immune Control of Virus Immunodeficiency Virus Reveals Limited Monkeys Naturally Infected with Simian Cells in Sooty Mangabey + Depletion of CD8

SIV infection of sooty mangabeys (SMs), a natural host species, does not cause AIDS despite high-level virus replication. In contrast, SIV infection of nonnatural hosts such as rhesus macaques (RMs) induces an AIDS-like disease. The depletion of CD8 (cid:1) T cells during SIV infection of RMs results in marked increases in plasma viremia, suggesting a key role for CD8 (cid:1) T cells in controlling levels of SIV replication. To assess the role that CD8 (cid:1) T cells play in determining the virologic and immunologic features of nonpathogenic SIV infection in SMs, we transiently depleted CD8 (cid:1) T cells in SIV-infected and uninfected SMs using a CD8 (cid:2) -speciﬁc Ab (OKT8F) previously used in studies of SIV-infected RMs. Treatment of SMs with the OKT8F Ab resulted in the prompt and profound depletion of CD8 (cid:1) T cells. However, in contrast to CD8 (cid:1) cell depleted, SIV-infected RMs, only minor changes in the levels of plasma viremia were observed in most SIV-infected SMs during the period of CD8 (cid:1) cell deﬁciency. Those SMs demonstrating greater increases in SIV replication following CD8 (cid:1) cell depletion also displayed higher levels of CD4 (cid:1) T cell activation and/or evidence of CMV reactivation, suggesting that an expanded target cell pool rather than the absence of CD8 (cid:1) T cell control may have been primarily responsible for transient increases in viremia. These data indicate that CD8 (cid:1)
Burrage, Clare and Brax, Philippe and Englert, Christoph and Spannowsky, Michael (2016) LHC signatures of scalar dark energy. Physical Review D, 94 . 084054/1-084054/10. ISSN 1550-2368

Scalar dark energy fields that couple to the standard model can give rise to observable signatures at the LHC. In this work, we show that t ¯ t þ missing energy and monojet searches are suitable probes in the limit where the dark energy scalar is stable on collider distances. We discuss the prospects of distinguishing the dark energy character of new physics signals from dark matter signatures and the possibility of probing the self-interactions of the dark energy sector.
Activation Is MyD88 and TLR2 Dependent Neisserial Porin-Induced Dendritic Cell

Neisserial porins have been shown to act as B cell mitogens and immune adjuvants. PorA and PorB are the major outer membrane porin proteins of the human pathogen Neisseria meningitidis . We have shown that the mechanism of the immunopotentiating capability of porin involves up-regulation of the T cell costimulatory ligand, CD86. Due to neisserial porin’s ability to activate B cells and potentiate immune responses, we hypothesized that porin also employs the potent immune stimulatory function of dendritic cells (DC). We examined the ability of puriﬁed N. meningitidis PorB to induce maturation of murine splenic and bone marrow-derived DC. PorB treatment induced DC maturation, as demonstrated by increased expression of CD86 and class I and II MHC molecules. In addition, PorB not only enhanced the allostimulatory activity of DC, but also augmented the ability of DC to stimulate T cells in an Ag-speciﬁc manner. PorB-matured DC secreted the inﬂammatory cytokine IL-6, which may have implications for the adjuvant property of porin. Induction of IL-6 by PorB is also signiﬁcant because IL-6 is one of a number of cytokines produced during infection with N. meningitidis and may be involved in the inﬂammatory process observed during infection and disease. We previously demonstrated the requirement of MyD88 and TLR2 for PorB-induced B cell activation. In the present study, MyD88 and TLR2 were also essential for PorB-induced DC activation. This work is signiﬁcant for elucidating the mechanism(s) of neisserial porin’s immune stimulatory activity. The Journal of Immunology, 2005, 174: 3545–3550.
Stochastic Modeling in Nanoscale Biophysics: Subdiffusion within Proteins

Advances in nanotechnology have allowed scientists to study biological processes on an unprecedented nanoscale molecule-by-molecule basis, opening the door to addressing many important biological problems. A phenomenon observed in recent nanoscale single-molecule biophysics experiments is subdiffusion, which largely departs from the classical Brownian diffusion theory. In this paper, by incorporating fractional Gaussian noise into the generalized Langevin equation, we formulate a model to describe subdiffusion. We conduct a detailed analysis of the model, including (i) a spectral analysis of the stochastic integro-differential equations introduced in the model and (ii) a microscopic derivation of the model from a system of interacting particles. In addition to its analytical tractability and clear physical underpinning, the model is capable of explaining data collected in ﬂuorescence studies on single protein molecules. Excellent agreement between the model prediction and the single-molecule experimental data is seen.