Miracle-dz/UniFAR-FTUs huggingface dataset:
Deciphering the Tumor–Immune–Microbe Interactions in HPV-Negative Head and Neck Cancer

Patients with human papillomavirus-negative head and neck squamous cell carcinoma (HPV-negative HNSCC) have worse outcomes than HPV-positive HNSCC. In our study, we used a published dataset and investigated the microbes enriched in molecularly classified tumor groups. We showed that microbial signatures could distinguish Hypoxia/Immune phenotypes similar to the gene expression signatures. Furthermore, we identified three highly-correlated microbes with immune processes that are crucial for immunotherapy response. The survival of patients in a molecularly heterogenous group shows significant differences based on the co-abundance of the three microbes. Overall, we present evidence that tumor-associated microbiota are critical components of the tumor ecosystem that may impact tumor microenvironment and immunotherapy response. The results of our study warrant future investigation to experimentally validate the conclusions, which have significant impacts on clinical decision-making, such as treatment selection.
COVID-19 Vaccine Hesitancy and Implications for Economic Recovery: Evidence from Nelson Mandela Bay Municipality in South Africa

The phenomenon of vaccine hesitancy is a growing threat to public health with far-reaching implications. The widening gap between the vaccinated and the proportion of vaccinated people needed for herd immunity raises two critical research questions that are of interest to practitioners, researchers, and policymakers: (1) What determines one’s decision to be vaccinated? (2) What is the implication of COVID-19 vaccine hesitancy for economic recovery? In this study, we use empirical data in the context of South Africa to investigate factors affecting COVID-19 vaccine hesitancy and their implications for economic recovery. Findings reveal key socio-demographic and institutional drivers of COVID-19 vaccine hesitancy, which include age (the youth are more hesitant), inadequate information on the vaccine (those who perceive they have adequate information are vaccinated), trust issues in government institutions, conspiracy beliefs, vaccine-related factors, and perceived side effects associated with the vaccine. Additionally, an individual’s decision to remain hesitant about COVID-19 vaccination has implications for businesses and the economy by limiting movement and trade, increasing unemployment, and causing a resurgence of new variants. Based on the findings, action plans such as information dissemination, convenience vaccination centers, consistent communications, and targeted campaign strategies are recommended for improving vaccine uptake and a positive economic recovery.
The Effect of Organizational Justice on Job Satisfaction: The Mediating Role of Psychological Empowerment

This study aims to examine the effect of organizational justice on job satisfaction by considering psychological empowerment as a mediating variable. This research was conducted at Dr. Moewardi Surakarta Regional General Hospital, involving 125 respondents of Regional Public Service Agency employees. The analysis in this study used SEM-PLS with Smart PLS version 3.0. The results in this study are that organizational justice has a positive and significant effect on job satisfaction, organizational justice has a positive and significant effect on psychological empowerment. Meanwhile, psychological empowerment has no effect on job satisfaction and psychological empowerment does not mediate the effect of organizational justice on job satisfaction. Future research is suggested to develop research on the effect of organizational justice on job satisfaction by considering other variables in order to obtain more in-depth results.
The relationship between workplace violence, emotional exhaustion, job satisfaction and turnover intention among nurses during the COVID-19 pandemic

Objectives: Workplace violence is a major issue in society, business and healthcare settings. It adversely affects both employee safety and their ability to provide healthcare services. Aim: This study examined the association between workplace violence, emotional exhaustion, job satisfaction and turnover intention among nurses during the COVID-19 pandemic. Methods: We collected data from 513 nurses. We conducted ‘Process Macro’ analysis. Firstly, we included three mediators in the model: job satisfaction, workplace violence and emotional exhaustion. Secondly, we used work hours and anxiety as moderators of the relationship between workplace violence and turnover intention. Results: The findings revealed statistical significance that job satisfaction and workplace violence mediated the relationship between emotional exhaustion and nurse turnover intentions. Work hours and anxiety also moderated the relationship between workplace violence and nurses’ turnover intention. Conclusion: Respondents indicated that they were most affected by verbal violence during this time. Workplace violence is a negative factor that affects nurses’ work, affecting them physically and psychologically. This occupational risk should be considered when evaluating nurses exposed to violence, as it affects job satisfaction and turnover intentions. The main theoretical contribution of this research is the identification of the association between workplace violence, emotional exhaustion, job satisfaction and turnover intention among nurses during the COVID-19 pandemic. It is clear that the research findings will be useful for healthcare professionals. The findings may have practical implications for healthcare administrators and their staff.
ESTRATÉGIAS DAS COORDENAÇÕES DOS CURSOS DE CIÊNCIAS CONTÁBEIS PARA COMBATER A EVASÃO

A evasão escolar é um fenômeno presente no sistema educacional público e privado que gera grandes impactos sociais. No ensino superior brasileiro, as taxas de evasão, nos cursos presenciais e a distância, correspondem a 24,9% e 28,8%, respectivamente. O presente estudo se propôs a analisar e identificar, na percepção dos coordenadores de curso, as ações de retenção praticadas nos cursos de Ciências Contábeis do Brasil e a sua relação com o nível de evasão da IES. A amostra ficou composta por 155 coordenadores vinculados a IES privadas (83,2%) e públicas (16,8%) de todas as regiões brasileiras. Para tratamento dos dados, foram utilizadas a estatística descritiva, as comparações múltiplas de proporções, as comparações de médias e a regressão linear múltipla. Os resultados da regressão demonstraram que as IES em que a coordenação promove a integração acadêmica dos alunos tendem a apresentar menores taxas de evasão, incluindo-se ações para acompanhamento e intervenção em relação às dificuldades de ensino-aprendizagem ao longo do curso. Também se mostraram relevantes o acompanhamento à frequência do aluno, bem como o oferecimento de orientações sobre o curso aos alunos no ato de matrícula. Identificou-se ainda que os cursos do turno noturno apresentam maiores índices de evasão se comparados aos do turno integral. Os testes estatísticos, por sua vez, indicaram que as bolsas de auxílio financeiro e os descontos nas mensalidades escolares oferecidas pelas IES, bem como a oferta de monitorias ou atendimento extraclasse para suprir deficiências do aluno ao longo do curso, tendem a reduzir as taxas de evasão. Infere-se, com base nos resultados, que, à medida que IES, coordenadores e docentes adotarem estratégias semelhantes a essas, e que contribuam com o debate sobre políticas que visem à retenção dos estudantes universitários, o fenômeno da evasão poderá ser erradicado ou, pelo menos, minimizado no meio universitário.
Chiral “doped” MOFs: an electrochemical and theoretical integrated study

This work reports on the electrochemical behaviour of Fe and Zn based metal-organic framework (MOF) compounds, which are “doped” with chiral molecules, namely: cysteine and camphor sulfonic acid. Their electrochemical behaviour was thoroughly investigated via “solid-state” electrochemical measurements, exploiting an “ad hoc” tailored experimental set-up: a paste obtained by carefully mixing the MOF with graphite powder is deposited on a glassy carbon (GC) surface. The latter serves as the working electrode (WE) in cyclic voltammetry (CV) measurements. Infrared (IR), X-ray diffraction (XRD) and absorbance (UV-Vis) techniques are exploited for a further characterization of the MOFs’ structural and electronic properties. The experimental results are then compared with DFT based quantum mechanical calculations. The electronic and structural properties of the MOFs synthesized in this study depend mainly on the type of metal center, and to a minor extent on the chemical nature of the dopant.
Effect of forest fire on trees, shrubs and regeneration behavior in Chir Pine forest in northern aspects under Solan forest division, Himachal Pradesh

Effect of forest fire on woody vegetation and regeneration behavior was studied in Chir pine forest situated between 1150-1800 m in Solan Forest Division in Himachal Pradesh, India. Four fire affected Sites and one control Site were surveyed for floristic composition, density, basal area, IVI, A/F, Shannon-Weaver index, Simpson’s Index of dominance (Cd), Species richness (d), Sorenson index (S) and natural regeneration potential of tree and shrubs. A total of 3 tree species and 10 shrub species were recorded on the five experimental sites. Fire resistant species were observed more in selected Chir pine forests. There was not observed any consistent trend for density, basal area, IVI, H. Sorenson’s index of similarity between fire affected and control sites for trees. Density and basal area in fire affected sites were lesser than control sites for shrubs. Contagious pattern of distribution for trees and shrubs was common. Seedlings density of trees and shrubs was higher on occasional fire affected sites than control sites. Density of saplings of trees was higher in control sites than fire affected sites.
A cross-sectional study on knowledge, attitude and behavior related to antibiotic use and resistance among medical and non-medical university students in Jordan

Irrational antibiotics use is a major reason for the spread of antibiotic resistance. Earlier studies from Jordan indicated irrational antibiotic use among the public. Our aim is to evaluate the current knowledge, attitude and behaviour regarding antibiotic use and reasons for resistance development among university students in Jordan. A cross-sectional, questionnaire-based survey involving medical and non-medical students at the University of Jordan was conducted. Response rate was 85% and the majority of the sample was non-medical female students. Scoring level analysis revealed inadequate knowledge, high consumption rates and self-medication among students regardless of their specialty. Forty four percent of non-medical and 28.1% medical students agreed that antibiotics cure common colds and viral infections. Almost 61% of students did not complete their last course of antibiotic, 31.2% requested antibiotic prescriptions from clinicians and 37.5% were prescribed antibiotics over the phone. In conclusion, gaps in terms of knowledge, attitude and practice regarding antibiotics use among students were observed. National education programs should target these gaps aiming at increasing awareness on proper antibiotics use and its association with drug resistance. Enforcing antibiotic regulations at a national level is paramount targeting over the counter sale hence, reducing self-medication and high rates of consumption. Key words: Antimicrobial resistance, prescribing practice, health education.
Ventricular interdependence in critically ill patients: from physiology to bedside

The review focuses on the mechanism of ventricular interdependence, a frequently encountered phenomena, especially in critically ill patients. It is explained by the anatomy of the heart, with two ventricles sharing a common wall, the septum, and nested in an acutely inextensible envelope, the pericardium. In pathological situation, it results in abnormal movements of the interventricular septum driven by respiration, leading to abnormal filling of one or the other ventricle. Ventricular interdependence has several clinical applications and explains some situations of hemodynamic impairment, especially in situations of cardiac tamponade, severe acute asthma, right ventricular (RV) overload, or more simply, in case of positive pressure ventilation with underlying acute pulmonary hypertension. Ventricular interdependence can be monitored with pulmonary arterial catheter or echocardiography. Knowledge of this phenomena has very concrete clinical applications in the management of filling or in the prevention or treatment of RV overload.
Tools for Etiologic Diagnosis of Drug-Induced Allergic Conditions

Drug hypersensitivity reactions are a serious concern in clinical practice because they can be severe and result in lifelong sequelae. An accurate diagnosis and identification of the culprit drug is essential to prevent future reactions as well as for the identification of safe treatment alternatives. Nonetheless, the diagnosis can be challenging. In vivo and in vitro tests can be helpful, although none are conclusive; therefore, the tests are not usually performed in isolation but as part of a diagnostic algorithm. In addition, some in vitro tests are only available in research laboratories, and standardization has not been fully accomplished. Collaborating research is needed to improve drug hypersensitivity reaction diagnosis. In this review, we update the current available in vivo and in vitro tools with their pros and cons and propose an algorithm to integrate them into clinical practice.
On the limit theory of mixed to unity VARs: Panel setting with weakly dependent errors

In this article, we re‐visit a recent idea of Phillips and Lee (2015. Econometric Reviews 34: 1035 ‐ 1056). They examine an empirically relevant situation when two time series exhibit different degrees of non‐stationarity and one need to learn whether their persistence properties are the same. By bridging the asymptotic theory of local to unity and mildly explosive processes, they construct a Wald test for the commonality of the long‐run behavior of the series. However, inference is complicated by the fact that their statistic does not converge in distribution under the null and diverges under the alternative. This is true if the parameters of the data generating process are known and a re‐normalizing function can be constructed. If the parameters are unknown, which will be the case in practice, the test statistic may be divergent even under the null. We solve this problem by converting the original setting of vector time series into a panel setting with N individual vector series. We show that the proposed panel Wald test statistics converge to chi‐squared distribution which is free of nuisance parameters under the null hypothesis of common local to unity behavior. The result is an extreme example of simplified asymptotics brought about by panel data.
PRODUCTIVE AND ECONOMIC PERFORMANCE OF BROWN SWISS COWS AT DIFFERENT STAGES OF LACTATION FED TWO CRUDE PROTEIN LEVELS

Background. Dairy cows convert between 24 to 32% of dietary nitrogen (N2) into milk protein, the rest of the dietary N2 is excreted in urine and feces which contributes to environmental N2 pollution. Besides the N2 excretions, crude protein (CP) represents up to 69% of the diet´s total cost. Therefore, the best way to reduce environmental pollution and increase dairy profits is the reduction of crude protein in the diet of cows. Objective. To determine the productive and economic performance of Brown Swiss cows at different stages of lactation fed two crude protein levels 14 vs 16%. Methodology. Twenty-three multiparous Brown Swiss cows stratified by stage of lactation as early (EL), mid (ML), and late (LL) were used and subjected to two CP levels 14 and 16% on a crossover design with two experimental periods (EP) of three weeks each. Cows on experimental CP 14% in the EP1 switched to 16% in the EP-2, whereas cows that received a 16% diet in the first EP switched to 14% in the EP2. Milk-to-feed price ratio and income over-feeding cost were estimated as indicators of profitability. Results. The were no significant differences in any response variable due to dietary crude protein (P > 0.05), except for milk protein yield (kg/day) (P = 0.03), where 16% CP had higher yields (0.57) than 14% CP (0.55, kg/day). Cows in early and mid-lactation stages had higher performance than in late lactation (P < 0.05), on most of the response variables. Income over feeding-costs were 0.24 and 0.21 ($ USD/kg) for CP 14 and 16%, respectively. Total income over feeding cost per treatment was $1,020 for CP 14%, and $917 for CP 16%. Implications. The reduction of crude protein in the diet of lactating cows will allow reductions if milk production cost, as well as reductions of N2 excretions to the environment. Conclusions. The productive performance of the cows was not affected by a reduction of crude protein in the diet, but the reduction of crude protein resulted in lower milk production cost and higher income-over feeding cost.
A Comparative Prospective Study in Evaluating Candida spp. In Vitro Susceptibility through Micronaut-AM and Sensititre Yeast-One

Background. Among invasive fungal infection pathogens, Candida spp. represent the most common aetiological agents. The increasing rate of severe infections and the emergence of antimicrobial resistance highlight the importance of in vitro susceptibility testing. The EUCAST and the CLSI have established reference microdilutions that are reliable but difficult to apply in a laboratory routine. Commercial microdilutions could represent a valuable alternative within a diagnostic workflow. Methods. A number of 50 Candida spp. collected from positive blood samples simultaneously underwent the Sensititre Yeast-One microdilution as a standard susceptibility test and the Micronaut-AM as an experimental method. A comparison between the two techniques was produced, evaluating the effectiveness of the Micronaut-AM compared to the extensively consolidated Sensititre Yeast-One. Results. The two techniques revealed optimal agreement rates, confirming the reliability of the commercial microdilution kits within the diagnostic workflows. The results showed remarkable concordance for both susceptible and resistant isolates, highlighting slight variations in the different identified Candida species. Conclusions. Future studies about antifungal susceptibility testing should be encouraged, including molecular confirmation of possible resistance phenotypes and extended isolate numbers for the different Candida species. Moreover, it would be interesting to plan clinical trials after the execution of the examined commercial microdilution methods.
Methods of Analysis and Identification of Betulin and Its Derivatives

This scientific work presents practical and theoretical material on the methods of analysis and identification of betulin and its key derivatives. The properties of betulin and its derivatives, which are determined by the structural features of this class of compounds and their tendency to form dimers, polymorphism and isomerization, are considered. This article outlines ways to improve not only the bioavailability but also the solubility of triterpenoids, as well as any hydrophobic drug substances, through chemical transformations by introducing various functional groups, such as carboxyl, hydroxyl, amino, phosphate/phosphonate and carbonyl. The authors of this article summarized the physicochemical characteristics of betulin and its compounds, systematized the literature data on IR and NMR spectroscopy and gave the melting temperatures of key acids and aldehydes based on betulin.
Impact of Candida railenensis during fermentation on the aromatic profile of Vidal blanc icewine

Mixed culture fermentation with non-Saccharomyces yeasts and Saccharomyces cerevisiae as multi-starters has more advantages than spontaneous fermentation, and wine products with distinctive and pleasant aromas can fulfill the diverse demands of consumers. This study was carried out to illuminate the effect of sequential inoculation of indigenous Candida railenensis and S. cerevisiae on alcoholic fermentation behavior and chemical and aromatic characteristics of Vidal blanc icewine. During the mixed culture fermentation, C. railenensis was present in the initial and middle stages but was absent after 14 days. The results of basic chemical parameters showed that the glycerol content in the mixed culture-fermented icewine was higher than that of the pure fermented icewine, but the acetic acid content was the opposite. In terms of volatile aroma compounds, C. railenensis in the mixed culture fermentation reduced some metabolites such as lower alcohols, 1-hexanol, 3-methylthiopropanol, and their unpleasant notes and increased the production of some desired volatile aroma compounds such as benzaldehyde, β-damascenone, 2-furanmethanol, and 5-methyl furfural associated with rose, honey, nut, and caramel characteristics. Furthermore, C. railenensis also changed the sensory performance of icewine by participating in the fermentation of S. cerevisiae. These findings suggest that C. railenensis with positive enological properties has the ability to be used in icewine production, which has never been reported before.
The Antecedents of Collaborative Behavior for Climate Change Mitigation among South Koreans: The Moderation Analyses of a Sense of Community as Responsibility, Neighborliness, and Trust

The collective efforts of various social actors from different sectors have contributed to climate change mitigation. Identifying the important antecedents of collaborative behavior to address climate change helps us understand the underlying process. This study focused on important theoretical frameworks that determine collaborative behavior as civic engagement. Specifically, the study examines perceived societal risk to future generations, sense of community as responsibility (SOC-R), neighborliness, and trust in collaborative behavior to mitigate climate change. It also investigates the boundary conditions of the effects of societal risk perception on collaborative behavior change by examining the moderating roles of SOC-R, neighborliness, and trust. A nationwide online survey was conducted in South Korea. The findings reveal significant effects of societal risk perception and SOC-R on behavioral intention. Moreover, SOC-R and trust moderated the causal relationship between societal risk perception and behavioral intention, such that the relationship was more pronounced at lower SOC-R and trust. These findings have implications for communication practices and policy making that motivate collective action against climate change in South Korea.