Miracle-dz/UniFAR-FTUs huggingface dataset:
The Effect of MI VarnishTM on Caries Increment and Dietary Habits among 6- and 12-Year-Old Children in Riga, Latvia: A 3-Year Randomized Controlled Trial

Aims: This randomized controlled trial investigated the effect of MI VarnishTM (5% NaF/ CPP-ACP) on caries increment in 6and 12-year-old children in Riga, Latvia within 36 months. Methods: Forty-eight 6-year-old children (Group 1) and forty-seven 12-year-old children (Group 3) received quarterly varnish application, while forty-eight 6-year-old children (Group 2) and thirty-seven 12-yearold children (Group 4) did not have varnish applied. All children/parents received the same preventive advice. All children were visually examined using ICDAS-II criteria. Questionnaires on dietary habits were completed by the children/parents at baseline and after 36 months. DMFS and dfs were calculated from ICDAS data. The statistical analysis was performed (α = 0.05) using a Chi-squared test, paired t-test (Welch test) and the Pearson correlation coefficient. The trial registration number is ISRCTN10584414. Results: In Group 1 versus Group 2, the DMFS(SD) (Baseline/36 months) values were 5.02(5.85)/13.21(6.67) (p < 0.001) versus 2.65(4.54)/10.81(6.14) (p < 0.001), respectively; the dfs(SD) (Baseline/36 months) values were 36.75(12.96)/24.04(12.9) (p < 0.001) versus 33.67(12.74)/23.88(11.91) (p < 0.001), respectively. In Group 3 versus Group 4, the DMFS(SD) (Baseline/36 months) values were 48.62(23.18)/70.96(23.28) (p < 0.001) versus 34.73(17.99)/54.95(16.09) (p < 0.001), respectively; the dfs(SD) (Baseline/36 months) values were 1.7(4.4)/0 (p < 0.05) versus 2(6.39)/0 (p = 0.06), respectively. The prevalence of caries (dfs + DMFS) decreased by 4.52 (p < 0.001) and 1.63 (p < 0.001) in Groups 1 and 2, respectively, but increased by 20.64 (p < 0.001) and 18.22 (p < 0.001) in Groups 3 and 4, respectively. An analysis of the questionnaires indicated the habitual, frequent consumption of a sugary diet by all the children. A significant correlation (r = 0.321; p < 0.05) was observed between caries increment and the frequency of daily intake of sugary snacks, soft drinks and tea with sugar at baseline only in Group 1. Conclusions: A quarterly application of MI varnish (CPP-ACP/fluoride) reduced caries increment in 6and 12-year-old children in Riga, Latvia.
Fixed points and chaotic dynamics for expansive-contractive maps in Euclidean spaces, with some applications

In this work we introduce a topological method for the search of fixed points and periodic points for continuous maps defined on generalized rectangles in finite dimensional Euclidean spaces. We name our technique "Stretching Along the Paths" method, since we deal with maps that expand the arcs along one direction. Our technique is also significant from a dynamical point of view, as it allows to detect complex dynamics. In particular, we are able to prove semi-conjugacy to the Bernoulli shift and thus positivity of the topological entropy, the presence of topological transitivity and sensitivity with respect to initial conditions, density of periodic points. Moreover, our approach, although mathematically rigorous, avoids the use of sophisticated topological theories and it is relatively easy to apply to specific models arising in the applications. For example we have here employed the Stretching along the paths method to study discrete and continuous-time models arising from economics and biology.
Linnik-type problems for automorphic L-functions; Problemes de type Linnik pour les fonctions L de formes automorphes

The thesis gave a fine study on the distribution of the coefficients of automorphic L-functions for GL(m) with m>1. In particular we have treated two types of problems: change of signs of these coefficients (when they are real) and their decompensation on the prime numbers. Chapter 2 is devoted to the results known concerning the first problem in the case of classical modular forms and to explain our motivation of research. In Chapter 3, we treated the case of primitive Maass forms and obtained an estimate of the subconvexity-type for the least integer n such that the n-th coefficient is negative. Chapter 4 is the main part of the thesis. For the coefficients of the L-function associated with an irreducible unitary cuspidal representation for GL(m) with m>1, we established an elegant inequality of Hecke type, which shows that these coefficients on the first m powers of an arbitrary unramified prime number cannot be small simultaneously. As an application, we obtained a polynomial type estimate for the least integer n such that the n-th coefficient is negative. In Chapters 5 and 6, we studied the long and short summations of coefficients of L-functions for GL(m) on the prime numbers to test their decompensation, respectively. In particular we gave a perfect generalization of Selberg's normal density theorem when m>1.
Further Details on Predicting IRT Difficulty

This supplementary material serves as technical appendix of the paper When AI Difficulty is Easy: The Explana-tory Power of Predicting IRT Difficulty (Mart´ınez-Plumed et al. 2022), published in The Thirty-Sixth AAAI Conference on Artificial Intelligence (AAAI-22) . The following sections give detailed information about 1) data gathering for benchmarks; 2) IRT properties and methodology followed; 3) learning models configuration and hyperparameter setting; 4) differences between difficulty prediction and class prediction; 5) the deployment and results of alternative approaches for difficulty estimation; 6) specifics and results us-ing a generic difficulty metric in different applications and 7) extended IRT applications.
The antecedents and outcomes of export market orientation: A bibliometric analysis

bibliometric; export market orientation; integrative analysis; TCCM framework Export market orientation has always been a central issue in the study of international business and marketing. Therefore, it is essential to put effort into understanding the concept and its application in real-life business. Following in-depth studies and critical review papers in previous years, this research paper focuses on synthesizing and analyzing empirical studies in the period from 2015 to 2021, revolving around theoretical issues, context, the main features of the object, and the methodology. Within a predetermined time frame, twenty critical papers on export market orientation were selected and analyzed. The result reveals in detail that there are sixteen antecedents and five outcomes of export market orientation, as well as the total of eight moderators and seven mediators influencing their relationships. Findings have indicated that in recent years, models and theories of earlier eras have been developed and many of them have reached maturity.
Equilibrium Model for Insulin-induced Receptor Down-regulation REGULATION OF INSULIN RECEPTORS IN DIFFERENTIATED BC3H-1 MYOCYTES*

The mechanism of insulin-induced down-regulation of surface membane insulin receptors was studied in the muscle cell line BC3H-1. Down-regulation for the differentiated myocytes is dose- and time-dependent with a half-maximum response at 0.5 nM insulin and a maximum decrease of 50% in the number of surface insulin receptors following exposure to 20 nM insulin for 18 h at 37 “C, as confirmed by Scatchard analysis. These receptors were fully recoverable upon lysis of the down-regulated myocyte with Triton X-100, dem-onstrating that down-regulation is mediated solely by insulin-induced receptor internalization without detectable receptor degradation. Phospholipase C treatment of intact down-regulated cells and Triton X-100 treatment after subcellular fractionation showed that no cryptic or masked receptors were detectable within the plasma membrane. Insulin-induced receptor inter- nalization was dependent upon cellular energy production, protein synthesis, and endocytosis, but was insen- sitive to agents which primarily affect lysosomal, cy-tolskeletal, or transglutaminase activities. The magnitude of insulin-induced down-regulation and the kinetics of down-regulation and recovery of cell surface receptors indicate that the surface and internal receptor pools are in dynamic equilibrium with each other. The kinetic data are accommodated by separate internalization rate constants for the un- occupied (0.01 h-l) and occupied (0.11 h-’) surface receptors and a single recycling rate constant (0.1 1 h-’) for the internalized receptors. This model also explains the previous apparently paradoxical finding in several other systems that down-regulation is more sensitive to hormone than
Azelnidipine Exhibits In Vitro and In Vivo Antiviral Effects against Flavivirus Infections by Targeting the Viral RdRp

Flaviviruses, represented by Zika and dengue virus (ZIKV and DENV), are widely present around the world and cause various diseases with serious consequences. However, no antiviral drugs have been clinically approved for use against them. Azelnidipine (ALP) is a dihydropyridine calcium channel blocker and has been approved for use as an antihypertensive drug. In the present study, ALP was found to show potent anti-flavivirus activities in vitro and in vivo. ALP effectively prevented the cytopathic effect induced by ZIKV and DENV and inhibited the production of viral RNA and viral protein in a dose-dependent manner. Moreover, treatment with 0.3 mg/kg of ALP protected 88.89% of mice from lethal challenge. Furthermore, using the time-of-drug-addition assay, the enzymatic inhibition assay, the molecular docking, and the surface plasmon resonance assay, we revealed that ALP acted at the replication stage of the viral infection cycle by targeting the viral RNA-dependent RNA polymerase. These findings highlight the potential for the use of ALP as an antiviral agent to combat flavivirus infections.
Kirubhakaran S M

SARSCOV-2 a RNA virus which produce a serious ill-effects and brings the world under a common word Lockdown. Thus lockdown brings down the rate of spreading of cases, but severity of the illness is managed by combined therapy both Modern and Traditional system of medicine (Siddha, Ayurveda, Homeopathy). Immune boosting herbs is need of the hour in this pandemic situation. Immune boosters improves overall immunity of the host through cellular and humoral immunity. During Dengue pandemic situation a polyhebral preparation Nilavembu kudineersiddha sastric medicine and Carica papaya leaf extract highly works. During this pandemic covid situation Tulsi, Lemon, Arathai and siddha sastric medicine kabasura kudineer works in prevention, mild and moderate cases. There is a growing interest to the herbal medicine to modulate the complex immune system in preventing infections. The aim of the review is to give hope and to boost the research in herbal medicines during this pandemic situation. 490 * Corresponding Author:
ANALYSIS OF USERS’ PERCEPTIONS ON MOBILE ELECTRONIC COMMERCE OF FASHION

This study explores the dimensions of users’ perceptions on mobile electronic commerce (m-commerce) of fashion items. This type of digital commerce leads the ranking when it comes to the volume of online sales in Brazil, and identifying the factors that impact on user’s purchase intent is crucial for service providers in the area. The development of digital platforms is also essential. Due to the quantitative nature of this study, a questionnaire with 15 items was developed, and applied to a sample of 110 users. The results showed adapted dimensions of the UTAUT model and related to the area of fashion: Effort Expectancy, Performance Expectancy, and Perceived Satisfaction. This research adds an empirical work that uses UTAUT theory applied to fashion m-commerce. The managerial contribution is to identify the perceptual profile of its users, which is crucial for managing companies' marketing strategies. In the academic context, it contributes to the investigation of a theme that has been little explored, but that has great potential in the area of information and communication technology.
Comparison Epidemiology between Tuberculosis and COVID-19 in East Java Province, Indonesia: An Analysis of Regional Surveillance Data in 2020

Tuberculosis and COVID-19 are among the infectious diseases that constitute a public health concern. Therefore, this study aims to examine the recent epidemiology of tuberculosis and COVID-19 in East Java Province, Indonesia, in 2020. Case-based surveillance data were acquired with a retrospective design between January and December 2020 by the East Java Health Officer. The data were analyzed using Quantum Geographic Information System (QGIS) for mapping, and Microsoft Excel for recording. Furthermore, the statistical analysis (Spearman correlation test) was carried out via Statistical Package for Social Science (SPSS) applications. A total number of 38,089 confirmed cases of tuberculosis was recorded, with an incidence rate of 95.49/100,000 population, a case fatality rate (CFR) of 3.6%, and an average treatment success rate of 87.78%. COVID-19 is a new viral disease, with a total of 84,133 confirmed COVID-19 cases in East Java, with an incidence rate of 232.9/100,000 population. The highest incidence rate was found in Mojokerto city, while the lowest was found in Sampang. Furthermore, the CFR values of tuberculosis and COVID-19 were 1.4% and 6.8%, respectively. The regional survey in East Java Province showed that the incidence of tuberculosis remains high. This indicated that the search for active cases and preventive promotion was not completed. Therefore, inter-sectoral collaboration can be adapted to provide suitable tuberculosis health care.
Symmetric Waves Are Traveling Waves

We show that horizontally symmetric water waves are traveling waves. The result is valid for the Euler equations, and is based on a general principle that applies to a large class of nonlinear partial differential equations, including some of the most famous model equations for water waves. A detailed analysis is given for weak solutions of the Camassa-Holm equation. In addition, we establish the existence of nonsymmetric linear rotational waves for the Euler equations.
Scaling limit of the invasion percolation cluster on a regular tree

We prove existence of the scaling limit of the invasion percolation cluster (IPC) on a regular tree. The limit is a random real tree with a single end. The contour and height functions of the limit are described as certain diusive stochastic processes. This convergence allows us to recover and make precise certain asymptotic results for the IPC. In particular, we relate the limit of the rescaled level sets of the IPC to the local time of the scaled height function.
THE IDEA OF UNIVERSITY FROM A HUMANIST APPROACH: THE CONTRIBUTION OF SERVICE-LEARNING AS A PHILOSOPHY OF HIGHER EDUCATION La idea de Universidad desde un enfoque humanista: la contribución del aprendizaje-servicio como filosofía de la educación superior

This paper is part of a new line of academic work that reflects on the idea of the university and the development of higher education from a philosophical-educational approach. Our starting hypothesis is that the identity crisis that the university is going through is not negative. On the contrary, it is forcing the academic community to elaborate and propose responses that are revitalizing the very notion of higher education from a humanistic approach. In this context we propose service-learning as JUAN GARCÍA-GUTIÉRREZ & MARTA RUIZ-CORBELLA THE IDEA OF UNIVERSITY FROM A HUMANIST APPROACH: THE CONTRIBUTION OF SERVICE-LEARNING AS A PHILOSOPHY OF HIGHER EDUCATION 160 Ediciones Universidad de Salamanca / cc by-nc-nd Teri. 34, 2, jul-dic, 2022, pp. 159-176 a practical and normative philosophical-educational approach, and thus as an “ethical theory of human formation”, which helps to respond to the questions and challenges of the European Higher Education Area (EHEA). To this end, and following a methodology of critical-hermeneutic enquiry, we examine the construction of the EHEA through its constituent documents, while at the same time delving into and contrasting with the idea of university that is being demanded. This first movement, in which we try to establish a balance between more vocational and more liberal positions, will allow us to construct and analyse the theoretical consistency of the main contributions that service-learning (SL), as a philosophy of higher education, can make to the university and to the processes of development of the EHEA. We have grouped these theoretical consistencies into three contributions: service as a value in higher education; SL as an approach that aligns the classic pillars of the University and, finally, this methodology as a virtual proposal that helps us to reflect on the meaning of digital technologies in higher education.
Invariant varieties for polynomial dynamical systems

We study algebraic dynamical systems (and, more generally, $\sigma$-varieties) $\Phi:{\mathbb A}^n_{\mathbb C} \to {\mathbb A}^n_{\mathbb C}$ given by coordinatewise univariate polynomials by refining a theorem of Ritt. More precisely, we find a nearly canonical way to write a polynomial as a composition of "clusters". Our main result is an explicit description of the (weakly) skew-invariant varieties. As a special case, we show that if $f(x) \in {\mathbb C}[x]$ is a polynomial of degree at least two which is not conjugate to a monomial, Chebyshev polynomial or a negative Chebyshev polynomial, and $X \subseteq {\mathbb A}^2_{\mathbb C}$ is an irreducible curve which is invariant under the action of $(x,y) \mapsto (f(x),f(y))$ and projects dominantly in both directions, then $X$ must be the graph of a polynomial which commutes with $f$ under composition. As consequences, we deduce a variant of a conjecture of Zhang on the existence of rational points with Zariski dense forward orbits and a strong form of the dynamical Manin-Mumford conjecture for liftings of the Frobenius. We also show that in models of ACFA$_0$, a disintegrated set defined by $\sigma(x) = f(x)$ for a polynomial $f$ has Morley rank one and is usually strongly minimal, that model theoretic algebraic closure is a locally finite closure operator on the nonalgebraic points of this set unless the skew-conjugacy class of $f$ is defined over a fixed field of a power of $\sigma$, and that nonorthogonality between two such sets is definable in families if the skew-conjugacy class of $f$ is defined over a fixed field of a power of $\sigma$.
Dynamic Network Architectures for Deep Q-Learning

Artificial neural networks have become popular within a range of machine learning fields for their ability to solve complex problems, with one of the uses as function approximators in Q-learning. These networks generally have static architectures, which is a problem in the regard of artificial general intelligence, since no single specific architecture is optimal for all problems. In this thesis, we implement and evaluate a proof of concept for a novel approach of a dynamic network architecture, resulting in a model that can be seen as a combination of compressed classical table-based Q-learning and artificial neural networks. The model presented performs true tabula rasa deep Q-learning, starting with an empty network that is gradually extended with nodes when experiencing “surprising” events, and is capable of generalization by abstracting important features from noisy input. Finally, we show that the model can learn from delayed rewards in simple environments and compare it with the well-established DQN algorithm.
Starmerella bacillaris Strains Used in Sequential Alcoholic Fermentation with Saccharomyces cerevisiae Improves Protein Stability in White Wines

Haze can appear in white wines as a result of the denaturation and subsequent aggregation of grape pathogenesis-related (PR) proteins. Yeast cell-wall polysaccharides, particularly mannoproteins, represent a promising strategy to reduce the incidence of this phenomenon. The aim of this study was to evaluate the effects of 13 Starmerella bacillaris strains, in sequential fermentation with Saccharomyces cerevisiae, on wine protein stability of three white wines (Sauvignon blanc, Pinot grigio, and Manzoni bianco). The resulting wines were characterized in terms of their chemical composition, content of PR proteins and polysaccharides, and heat stability. In addition, the mannoprotein fraction was purified from six wines, five produced with S. bacillaris and one with S. cerevisiae EC1118 used as control. Generally, wines produced with S. bacillaris strains were more heat-stable, despite generally containing higher amounts of PR proteins. The increased heat stability of Starmerella wines was attributed to the stabilizing effect resulting from their higher concentrations of both total polysaccharides and mannoprotein fractions. In particular, for the most heat unstable wine (Manzoni bianco), the low MW mannoprotein fraction resulted to be the most involved in wine stability. The ability to produce wines with different heat stability was demonstrated to be strain-dependent and was more evident in the most unstable wines. By reducing fining waste, the use of S. bacillaris as an enological starter can be proposed as a new tool to manage wine protein stability for a more sustainable winemaking.
A Cross-cultural Investigation of the Effects of Explanations on Drivers’ Trust, Preference, and Anxiety in Highly Automated Vehicles

This study explored, in consideration of cultural differences, how explanation timing and permission of the automated vehicle’s (AV’s) actions affected drivers’ trust in, preference for, and anxiety about the AV. We conducted a video-based online survey study with 118 participants in different cultural contexts. Each participant experienced four conditions in highly automated driving: (1) no explanations, (2) explanations given before, or (3) after theAV acted, and (4) the option for drivers to approve or disapprove the AV’s action after explanations. We found that context cultures influenced drivers’ trust in and preference for the AV only when explanations were provided. Participants with higher-context cultures had higher trust in and preference for the AV. Such influence was augmented especially when the AV asked for permission after explanations. Our results have important implications for the design of in-vehicle interfaces. We suggest that AV manufacturers should incorporate cultural differences into AV explanation interface design for global use.