Miracle-dz/UniFAR-FTUs huggingface dataset:
Inhibition of Pendrin by a small molecule reduces Lipopolysaccharide-induced acute Lung Injury

Rationale: Pendrin is encoded by SLC26A4 and its mutation leads to congenital hearing loss. Additionally, pendrin is up-regulated in inflammatory airway diseases such as chronic obstructive pulmonary disease, allergic rhinitis, and asthma. In this study, the effects of a novel pendrin inhibitor, YS-01, were investigated in an LPS-induced acute lung injury (ALI) mice model, and the mechanism underlying the effect of YS-01 was examined. Methods: Lipopolysaccharide (LPS, 10 mg/kg) was intranasally instilled in wild type (WT) and pendrin-null mice. YS-01 (10 mg/kg) was administered intra-peritoneally before or after LPS inhalation. Lung injury parameters were assessed in the lung tissue and bronchoalveolar lavage fluid (BALF). Pendrin levels in the BALF of 41 patients with acute respiratory distress syndrome (ARDS) due to pneumonia and 25 control (solitary pulmonary nodule) patients were also measured. Results: LPS instillation induced lung injury in WT mice but not in pendrin-null mice. Pendrin expression was increased by LPS stimulation both in vitro and in vivo. YS-01 treatment dramatically attenuated lung injury and reduced BALF cell counts and protein concentration after LPS instillation in WT mice. Proinflammatory cytokines and NF-κB activation were suppressed by YS-01 treatment in LPS-induced ALI mice. In BALF of patients whose ARDS was caused by pneumonia, pendrin expression was up-regulated compared to that in controls (mean, 24.86 vs. 6.83 ng/mL, P < 0.001). Conclusions: A novel pendrin inhibitor, YS-01, suppressed lung injury in LPS-induced ALI mice and our data provide a new strategy for the treatment of inflammatory airway diseases including sepsis-induced ALI.
MUSCULAR CONTRIBUTIONS TO CENTER OF MASS ACCELERATION DURING COUNTERMOVEMENT JUMPS

The purpose of this study was to study the contributions of individual leg muscles and muscle groups to accelerate the body’s centre of mass (COM) during countermovement jumps (CMJ). Ten NCAA college basketball players performed maximal effort CMJ. Motion capture and ground reaction force data were recorded and used as inputs to a musculoskeletal model. The muscular contributions COM acceleration were quantified with three separate induced acceleration analyses (i.e., unit-force, maximum-force, and absolute-force analysis). All three analyses suggest that (in rank order of magnitude) the soleus, gastrocnemii, and vastii muscles exhibited the largest contributions to COM acceleration during CMJ.
Gaseous Metabolism and Water Relations of the Zebra Finch, Taeniopygia castanotis

processes (Schmidt-Nielsen and SchmidtNielsen, 1952), these xerophilous birds do not appear to possess special physiological adaptations to desert conditions. Survival seems to depend upon exogenous water, tolerance of hyperthermia, and behavioral patterns which minimize heat stress (Bartholomew and Dawson, 1953, 1954; Dawson, 1954). That this is not necessarily the pattern for all species of desert birds is evident from recent investigations of the budgerygah (Melopsittacus undulatus) by Cade and Dybas (1962) and the poorwill (Phalaenoptilus nuttalli) by Bartholomew, Hudson, and Howell (1962). When deprived of water, captive budgerygahs survived long periods with little loss of body weight. By extraordinary capacities for evaporation, poor-wills were able to dissipate 174 per cent of concurrent metabolic heat production. These observations suggest that additional comparative studies of xerophilous species may reveal hitherto unsuspected adaptations. The investigation of the zebra finch, Taeniopygia castanotis (= Poephila guttata), reported herein represents an effort in that direction. The zebra finch is a common estrildinid of arid and semiarid regions in Australia where the daily maximum air temperatures may remain high for prolonged periods in the summer. The heat is generally accompanied by low humidity and scant and irregular rainfall; one third of the continent receives less than 26 cm. annually (Keast, 1959a). Because of its small size (10-13 gm.), problems of water economy in such an environment are especially acute in the zebra finch.
Application on PBL Teaching Model of Aalborg University in RS Course

: The AAU PBL teaching model is one of the most characteristic and influential teaching mode in the world. How to introduce this advanced teaching idea into our country and put it into practice? Based on the research and analysis AAU PBL model, the course of remote sensing software development is introduced as the object of teaching reform. In view of the deficiency in the current teaching mode, the paper discusses how to apply the PBL teaching mode to the course, and puts forward the teaching reform plan in each link of the teaching, which aims at enhancing the students' interest in learning and promoting the students' learning initiative. It will cultivate the students' learning ability and improve the teaching effect.
EXPERIMENTAL POPULATIONS OF DROSOPHILA PERSI‐MILIS FROM AN ALTITUDINAL TRANSECT OF THE SIERRA NEVADA

Populations of Drosophila pseudoobscura and D. persimilis throughout their respective distribution areas in western North America exhibit a very extensive and intricate pattern of gradients, or clines, in relative frequencies of the gene arrangements of the third chromosome -(Dobzhansky and Epling, 1944). These gradients may be very gradual over a wide area from north to south or west to east, or they may be rather steep in slope across an altitudinal transect of relatively short distance in a mountain range (Dobzhansky, 1948a). Within certain populations of D. pseudoobscura temporal fluctuations of less amplitude than the more extensive geographic differences have been observed (Dobzhansky, 1943, 1947a) while in some other populations of the same species long term trends were found (Dobzhansky, 1947b). It was by studying the behavior of these chromosomal types in artificial populations (Dobzhansky, 1947a, Wright and Dobzhansky, 1946) and later by statistical analysis of wild populations (Dobzhansky and Levene, 1948) that these gene arrangements were proved to have selective values and were shown to be-maintained at the observed frequencies by natural selection under both wild and artificial conditions. This information together with evidence of physiological differences between carriers of each arrangement -(Heuts, 1947b, 1948) leaves no doubt as to the importance of variation
In-vitro production of secondary metabolites in Gymnema sylvestre

Gymnemic acid (GA) is the principle constituent in Gymnema sylvestre, which is used in control of diabetics. Standardization of protocol for in-vitro culture and suspension culture to optimize the GA production was experimented. Gymnemic acid in yellowish-brown calli was 251.73 mg 100 g−1 dw when compared to 26.31 mg 100 g−1 dw in grey calli, which was mainly due to accumulation of gymnemic acid during culture. The cells were run in suspension culture at 120 rpm and sub-cultured every 20 days. The cell density, dry weight of cells, packed cell volume and viability of cells were the highest on day 15 irrespective of the treatments. The doubling time of cells was three days. The highest gymnemic acid was recorded in auxin-free medium (579.2 mg 100 ml−1) followed by sucrose 60 g l−1 (487.96 mg 100 ml −1) and mannitol (439.66 mg 100 ml−1). The fluorescent nature of gymnemic acid was identified and photo-micrographed.
Therapeutic Advances in Respiratory Disease

Since the first description of allergic bronchopulmonary aspergillosis (ABPA) in the 1950s there have been numerous studies that have shed light on the characteristics and immunopathogenesis of this disease. The increased knowledge and awareness have resulted in earlier diagnosis and treatment of patients with this condition. This article aims to provide a summary and updates on ABPA by reviewing the results of recent studies on this disease with a focus on articles published within the last 5 years. A systematic search of PubMed/Medline with keywords of ABPA or allergic bronchopulmonary aspergillosis was performed. All selected articles were reviewed with a focus on findings of articles published from December 2006 to December 2011. The relevant findings are summarized in this paper.
Asset Price Volatility and Investment Horizons: An Experimental Investigation

We study the effects of the investment horizon on asset price volatility using a Learning to Forecast experiment. We find that, for short investment horizons, participants coordinate on self-fulfilling trend extrapolating predictions. Price deviations are then reinforced and amplified, possibly leading to large bubbles and crashes in asset prices. For longer investment horizons such bubbles do not emerge and price volatility tends to be lower. This is due to the fact that, for longer horizons, there is more dispersion in participants' forecasts, and participants extrapolate trends in past prices to a lesser extent. We also show that, independent of the investment horizon, if the initial history of asset prices is already relatively stable before participants start their prediction task, price volatility remains small, with prices close to their fundamental values for the duration of the experiment.
Effect of Concrete Casting Conditions on Strength of Reinforced Concrete Walls

In this paper, quality of concrete used in reinforced concrete walls (RC-walls) in different phases from production to placing stage are studied. For this purpose, nine different RC-walls were cast which have different properties. Two different concrete classes were used in experiments. Some core specimens were drilled 14 and 28 days after the concrete is cast. Compressive test results of these core specimens are compared to control specimens which are cured in laboratory conditions. Factors such as concrete classes, mold type, placing with vibrator, curing are evaluated separately in every concrete specimen and results are discussed. It is found that compressive strength and hardness of the cores extracted from air cured RC-walls with low reinforcement bar spacing is lower than that of core specimens from RC-wall which are vibrated and wet cured specimens and have normal reinforcement bar spacing.
Preconceptional Minerals Administration Skewed Sex Ratio in Rat Offspring

Rational: Natural sex selection methods have been applied for several decades. Sex determination has scientific basis for prevention of genetic sex linked diseases like Duchenne muscular dystrophy and also, for personal, social, or cultural backgrounds. There are many methods for sex determination. Objective: Sex selection using (ART) Assisted Reproductive Technologies without doubt accurate and precise but unfortunately very expensive. So, this study was designed to assess the efficacy of adding different ions to the drinking water of rats on determination of rats’ offspring sexes. Subject and Methods: This study was carried out using 60 sexually mature male and female rats Sprague-Dawley rats, 2 months old, from central farm for experimental animals of Vacsera, Giza, Egypt. They were housed in 12hrs dark and 12-hrslight and fed a standard rodent pellet diet to acclimate for two weeks. Rats were divided into three groups: Group one: (Control) was chosen as a control group and pure drinking water was given to them. Group two (Na & K) was supplied with drinking water mixed with 1% sodium and potassium, and Group Three: (Ca & Mg) was supplied with drinking water mixed with 1% calcium and magnesium. The proestrous female cohabited (1:1) nightly with male. On the next morning the presence of a vaginal semen plug enabled the designation of day zero of pregnancy. The inseminated females were caged together in plastic cages until 17 days post pregnancy. At this point, pregnant females were housed individually and examined twice a day until parturition. Within 12hrs after parturition, the number of litters and the gender of pups were recorded. Pups were sexed by means of the anogenital distance, which is longer in males. Also, pups were examined for external malformations and diameter of crown rump length. The data were entered and analysed by SPSS software using t. test. Results: The results showed that effect of these minerals resulted in (56.81% male and 43.19% female) in Na& K fed group. While, in (Ca & Mg) fed group, (39.20% male and 60.79 % female). Also, by examining the delivered pups no signs of congenital or morphological anomalies were observed. Both crown rump and body weight values revealed that there is no statistically significant difference between the control and both (Na & K) and (Ca& Mg) groups. Also, there was statistically significant difference in male anogenital distance (mm) between (Na & K) (Ca& Mg) group which skewed gender toward females. Conclusions: This study concluded that; rats fed on (Na & K) ratios tended to have male progeny and those whom fed (Ca& Mg) ratios tended to have female progeny. This study reflect the potential role of such minerals on gender preselection; it could be have significant effect on the sex ratio of delivered rats’ offspring.
Test-Case Reduction via Test-Case Generation: Insights from the Hypothesis Reducer (Tool Insights Paper)

We describe internal test-case reduction , the method of test-case reduction employed by Hypothesis, a widely-used property-based testing library for Python. The key idea of internal test-case reduction is that instead of applying test-case reduction externally to generated test cases, we apply it internally , to the sequence of random choices made during generation, so that a test case is reduced by continually re-generating smaller and simpler test cases that continue to trigger some property of interest (e.g. a bug in the system under test). This allows for fully generic test-case reduction without any user intervention and without the need to write a speciﬁc test-case reducer for a particular application domain. It also signiﬁcantly mitigates the impact of the test-case validity problem, by ensuring that any reduced test case is one that could in principle have been generated. We describe the rationale behind this approach, explain its implementation in Hypothesis, and present an extensive evaluation comparing its eﬀectiveness with that of several other test-case reducers, including C-Reduce and delta debugging, on applications including Python auto-formatting, C compilers, and the SymPy symbolic math library. Our hope is that these insights into the reduction mechanism employed by Hypothesis will be useful to researchers interested in randomized testing and test-case reduction, as the crux of the approach is fully generic and should be applicable to any random generator of test cases.
The Influence of Low Serum Ferritin on Cardiac Autonomic Regulation in Libyan Patients

Heart rate variability (HRV) asses the difference of the period between consecutive heart beats, which vary under autonomic control. Decreased HRV has been recognized as strong indicator of risk related to adverse events in healthy individual as well as diseased patient, reflecting the vital role of the autonomic nervous system in maintain health (Vanderlei LC, et al 2009; Task for the European society of cardiology, the north American society of pacing and electrophysiology 1996) (Gandhi RA, et al 2010; Schroeder E, et al 2003).
CHANGES OF KINEMATICS DURING UNDERWATER UNDULATORY SWIMMING WITH INCREASING SWIMMING VELOCITY

The purpose of this study was to clarify about the changes of the kinematics during underwater undulatory swimming (UUS) with increasing the swimming velocity. Eight male collegiate swimmers performed three UUS trials at the 70%, 80% and 90% velocity of their maximum effort swimming velocity in a water flume. For motion analysis, a motion capture system was used to collect the three-dimensional coordinates. Using the collected coordinates, the kinematic parameters were analyzed in each trial. As the main results, the kick frequnecy increased and the relative duration of the un-propusive phase with hip extension and knee felxion decreased with increasing swimming velocity. Furtheremore, since the peak hip external roation velocity increased with increasing swimming velocity, it was considered that the hip external rotation velocity during the downward kicking related to controll the swimming velocity during underwater undulatory swimming.
EFFECT OF A NEUROMUSCULAR HOME TRAINING PROGRAM ON DYNAMIC KNEE VALGUS (DKV) IN LATERAL SINGLE-LEG LANDINGS

The purpose of the study was to investigate if an intervention program with focus on neuromuscular and feedback training in a home-based setting with supervision improves the leg alignment in recreational volleyball and basketball players. 16 players ran a 6-week neuromuscular intervention program in a home setting with video-based supervision. The control group just followed the regular training program. Before and after the intervention the DKV was measured as the peak knee valgus angle during the video-recorded landing after a lateral jump from a box using a 2D video analysis tool. While the DKV improved in the training group, no changes were found for the control group. The intervention was effective and can be recommended as a knee-injury mitigation program.
Asymmetric-partition replication for highly scalable distributed transaction processing in practice

Database replication is widely known and used for high availability or load balancing in many practical database systems. In this paper, we show how a replication engine can be used for three important practical cases that have not previously been studied very well. The three practical use cases include: 1) scaling out OLTP/OLAP-mixed workloads with partitioned replicas, 2) efficiently maintaining a distributed secondary index for a partitioned table, and 3) efficiently implementing an online re-partitioning operation. All three use cases are crucial for enabling a high-performance shared-nothing distributed database system. To support the three use cases more efficiently, we propose the concept of asymmetric-partition replication, so that replicas of a table can be independently partitioned regardless of whether or how its primary copy is partitioned. In addition, we propose the optimistic synchronous commit protocol which avoids the expensive two-phase commit without sacrificing transactional consistency. The proposed asymmetric-partition replication and its optimized commit protocol are incorporated in the production versions of the SAP HANA in-memory database system. Through extensive experiments, we demonstrate the significant benefits that the proposed replication engine brings to the three use cases.
Evidence from the Czech Republic

We extend the scarce evidence on labor supply in post-transition countries by estimating the wage elasticity of labor force participation in the Czech Republic. Using the household income survey data of 2002, we nd that a one-percent rise in the gross wage increases the probability of working by 0.16 and 0.02 percentage points for women and men, respectively. Taking into account the tax and bene t system, these semi-elasticities fall to 0.06 for women and 0.01 for men. We interpret the di erence between the estimates from the two speci cations as a summary measure of the welfare system disincentives. The estimated wage elasticities lie at the lower end of the range of values reported for mature market economies. This nding is consistent with the stylized fact that the labor supply in countries with high labor force participation rates, such as in the Czech Republic, tends to be less sensitive to wages. Abstrakt Tato studie odhaduje mzdovou citlivost participace na trhu práce v eské republice a roz2i°uje tak zna£n¥ omezené poznatky o chování nabídky práce v postkomunistických zemích. Z na2ich odhad· na datech z výb¥rového 2et°ení Mikrocenzus 2002 vyplývá, oe jednoprocentní nár·st hrubé mzdy zvy2uje pravd¥podobnost participace oen o 0.16 a muo· o 0.02 procentního bodu. Pokud v2ak vezmeme v úvahu systém daní a sociálních dávek a nahradíme hrubou mzdu faktickou (e ective) £istou mzdou, sníoí se tyto semi-elasticity na 0.06 u oen a 0.01 u muo·. Rozdíl mezi odhady pro hrubou a pro faktickou £istou mzdu interpretujeme jako indikátor míry demotivujícího vlivu sociálního systému na nabídku práce. Na2e odhady se nacházejí na spodní hranici hodnot odhadovaných pro dlouhodob¥ troní ekonomiky, coo je v souladu s dokumentovaným empirickým poznatkem, oe nabídka práce v zemích s vysokou participací na trhu práce, jak je tomu i v eské republice, reaguje na mzdy obvykle mén¥.
Sochiatrist: Signals of Affect in Messaging Data

Messaging is a common mode of communication, with conversations written informally between individuals. Interpreting emotional affect from messaging data can lead to a powerful form of reflection or act as a support for clinical therapy. Existing analysis techniques for social media commonly use LIWC and VADER for automated sentiment estimation. We correlate LIWC, VADER, and ratings from human reviewers with affect scores from 25 participants. We explore differences in how and when each technique is successful. Results show that human review does better than VADER, the best automated technique, when humans are judging positive affect ( 𝑟 𝑠 = 0 . 45 correlation when confident, 𝑟 𝑠 = 0 . 30 overall). Surprisingly, human reviewers only do slightly better than VADER when judging negative affect ( 𝑟 𝑠 = 0 . 38 correlation when confident, 𝑟 𝑠 = 0 . 29 overall). Compared to prior literature, VADER correlates more closely with PANAS scores for private messaging than public social media. Our results indicate that while any technique that serves as a proxy for PANAS scores has moderate correlation at best, there are some areas to improve the automated techniques by better considering context and timing in conversations.
FLEBOTOMÍNEOS (DIPTERA: PSYCHODIDAE) NA PERIFERIA DE SANTARÉM (PA). ESTRATIFICAÇÃO HORIZONTAL E FATORES AGRAVANTES PARA TRANSMISSÃO DOMICILIAR DE LEISHMANIOSES

espanolForam realizadas coletas de flebotomineos por meio de armadilhas luminosas tipo CDC, colocadas no intradomicilio (dormitorio) e peridomicilio (abrigos de animais) e procura de criadouros em bairros perifericos da cidade de Santarem, Brasil, onde houvesse registro de casos autoctones de leishmanioses, para tal foram selecionados: Jutai, Diamantino e Sto. Andre. Foram capturados 9.926 flebotomineos, distribuidos em 15 especies. As especies mais abundantes foram L. longipalpis (59,72%) e L. carmelinoi (35,47%). No bairro do Jutai foi capturada a maior quantidade de flebotomineos (6.031), seguido pelo bairro do Diamantino (2.390) e Sto. Andre (1.505). Houve maior densidade de individuos nos meses da estacao chuvosa. Na estratificacao horizontal, houve reducao significativa (p = 0,02) da fauna de flebotomineos na medida em que aumentava a distancia da mata residual. EnglishFueron realizadas colectas de flebotomineos por medio de trampas luminosas tipo CDC, colocadas intradomiciliarmente (dormitorio) y peridomiciliarmente (abrigos de animales) procurando los criaderos en barrios perifericos de la ciudad de Santarem, Brasil, haciendo la busqueda en los lugares en donde hubiese registro de casos autoctonos de leishmaniosis, fueran seleccionadas, las siguientes areas de trabajo: Jutai, Diamantino y Sto. Andre. Se capturaron 9.926 flebotomineos, distribuidos en 15 especies. Las especies mas abundantes fueron L. longipalpis (59,72%) y L. carmelinoi (35,47%). En el barrio de Jutai fue capturada la mayor cantidad de flebotomineos (6.031), seguido por el barrio de Diamantino (2.390) y Sto. Andre (1.505). Hubo mayor densidad de individuos en los meses de la estacion lluviosa. En la estratificacion horizontal hubo reduccion significativa (p = 0,02) de la fauna de flebotomineos, en la medida en que aumentaba la separacion de la floresta residual.