Miracle-dz/UniFAR-FTUs huggingface dataset:
Right-Wing Authoritarianism and Antipathy Toward Immigrants and Sexual Minorities in the Early Days of the Coronavirus Pandemic in Italy

Theory and research in social, evolutionary, and political psychology indicates that subjective feelings of threat and exposure to objectively threatening circumstances—including pandemic diseases—may contribute to increased affinities for political conservatism, right-wing authoritarianism, and prejudice against out-group members. We investigated these possibilities in the context of Italy, which was the first Western country to be severely affected by the spread of COVID-19. Early on in the pandemic, from March 3–8, 2020, we surveyed 757 Italian adults ranging in age from 18 to 78 years. Results revealed that antipathy toward immigrants and sexual minorities was predicted by (male) sex, COVID-19 anxiety, RWA, and political distrust. Furthermore, COVID-19 anxiety magnified the effect of RWA on disliking of immigrants and sexual minorities (but not obese or disabled people). Contrary to prediction, political trust failed to attenuate the effects of COVID-19 anxiety or RWA on out-group antipathy. Implications for the theories of right-wing authoritarianism and political ideology as motivated social cognition, as well as the state of contemporary Italian politics are discussed.
Application of Random Matrix Theory With Maximum Local Overlapping Semicircles for Comorbidity Analysis

In December 2019, the COVID-19 pandemic began, which has claimed the lives of millions of people around the world. This article presents a regional analysis of COVID-19 in Mexico. Due to comorbidities in Mexican society, this new pandemic implies a higher risk for the population. The study period runs from 12 April to 5 October 2020 761,665. This article proposes a unique methodology of random matrix theory in the moments of a probability measure that appears as the limit of the empirical spectral distribution by Wigner's semicircle law. The graphical presentation of the results is done with Machine Learning methods in the SuperHeat maps. With this, it was possible to analyze the behavior of patients who tested positive for COVID-19 and their comorbidities, with the conclusion that the most sensitive comorbidities in hospitalized patients are the following three: COPD, Other Diseases, and Renal Diseases.
Organoids From Mucinous Appendiceal Adenocarcinomas as High-Fidelity Models for Individual Therapy

Background Mucinous appendiceal adenocarcinoma (MAA) is a rare, heterogeneous disease. Patients with unrespectable mucinous appendiceal adenocarcinoma presenting with peritoneal spread are treated by intraperitoneal chemotherapy, hyperthermic intraperitoneal chemotherapy, systemic chemotherapy, or targeted therapy. However, there are no guidelines for efficacious drugs against mucinous appendiceal adenocarcinoma. Therefore, relevant high-fidelity models should be investigated to identify effective drugs for individual therapy. Methods Surgical tumor specimens were obtained from a mucinous appendiceal adenocarcinoma patient. The tissue was digested and organoid culture was established. H&E and immunohistochemistry staining as well as DNA sequencing was performed on tissue and organoid. The pathological characteristics and gene mutations of the organoid were compared to those of the original tumor. Drug sensitivity tests were performed on organoid and the patient clinical responds to chemotherapy and targeted therapy was compared. Results Organoids were successfully established and stably passaged. Pathological characteristics of organoids including H&E staining and expression of protein markers (CK20, CDX-2, STAB2, CD7, PAX8) were consistent to those of the original tumor. Moreover, the organoids carried the same gene mutations as the primary tumor. Sensitivity of the organoids to chemotherapeutic drugs and tyrosine kinase inhibitors included: 5-FU (IC50 43.95 μM), Oxaliplatin (IC50 23.49 μM), SN38 (IC50 1.02 μM), Apatinib (IC50 0.10 μM), Dasatinib (IC50 2.27 μM), Docetaxel (IC50 5.26 μM), Regorafenib (IC50 18.90 μM), and Everolimus (IC50 9.20 μM). The sensitivities of organoid to these drugs were comparable to those of the patient's clinical responses. Conclusion The mucinous appendiceal adenocarcinoma organoid model which retained the characteristics of the primary tumor was successfully established. Combined organoid-based drug screening and high throughput sequencing provided a promising way for mucinous appendiceal adenocarcinoma treatment.
The Time-Course Changes in Knee Flexion Range of Motion, Muscle Strength, and Rate of Force Development After Static Stretching

Previous studies have shown that longer-duration static stretching (SS) interventions can cause a decrease in muscle strength, especially explosive muscle strength. Furthermore, force steadiness is an important aspect of muscle force control, which should also be considered. However, the time course of the changes in these variables after an SS intervention remains unclear. Nevertheless, this information is essential for athletes and coaches to establish optimal warm-up routines. The aim of this study was to investigate the time course of changes in knee flexion range of motion (ROM), maximal voluntary isometric contraction (MVIC), rate of force development (RFD), and force steadiness (at 5 and 20% of MVIC) after three 60-s SS interventions. Study participants were sedentary healthy adult volunteers (n = 20) who performed three 60-s SS interventions of the knee extensors, where these variables were measured before and after SS intervention at three different periods, i.e., immediately after, 10 min, and 20 min the SS intervention (crossover design). The results showed an increase in ROM at all time points (d = 0.86–1.01). MVIC was decreased immediately after the SS intervention (d = −0.30), but MVIC showed a recovery trend for both 10 min (d = −0.17) and 20 min (d = −0.20) after the SS intervention. However, there were significant impairments in RFD at 100 m (p = 0.014, F = 6.37, ηp 2 = 0.101) and 200 m (p < 0.01, F = 28.0, ηp 2 = 0.33) up to 20 min after the SS intervention. Similarly, there were significant impairments in force steadiness of 5% (p < 0.01, F = 16.2, ηp 2 = 0.221) and 20% MVIC (p < 0.01, F = 16.0, ηp 2 = 0.219) at 20 min after the SS intervention. Therefore, it is concluded that three 60-s SS interventions could increase knee flexion ROM but impair explosive muscle strength and muscle control function until 20 min after the SS intervention.
Spatial Distribution and Conservation Strategies of Large Carnivores in Human-Dominated Landscape: A Case Study of Asiatic Black Bear in Jilin, China

Large carnivores maintain the balance of ecosystems. Understanding distribution and population changes are necessary prerequisites for scientific conservation strategy. The east of Jilin Province is the habitat of endangered Amur tiger (Panthera tigris altaica). The Chinese government has focused the monitoring on protecting the Amur tiger. However, little is known about Asiatic black bear (ABB, Ursus thibetanus) distribution, population dynamics in the wild, and protection awareness of local residents in Jilin Province, China. We conducted a integrative survey in mountain areas of eastern Jilin to determine ABB distribution. We explored the drivers of the distribution of ABB in Jilin using logstic regression, we further predicted the habitat suitability and potential suitable habitat of the ABB. Totally, we surveyed 112 grids (15 km × 15 km) from November 2015 to January 2019. Logistic regression analysis revealed that the main factors driving ABB distribution in Jilin are forest coverage, distance from protected areas, distance from main roads (railways and highways), and distance from water bodies. The results of questionnaire survey showed that the local residents’ understanding of ABB distribution is congruent with our field research. They believed that the number of ABBs has gradually increased in the past ten years. Nevertheless, the local residents have a negative attitude toward the ABBs, which may adversely affect efforts to protect them, possibly leading to more conflicts between humans and bears. Therefore, there is a need to consider ways to change the attitude of the locals through the strengthening of the protection propaganda and advocating management as being critical for the protection of ABBs. Our research provides a scientific basis for future conservation planning. We recommend taking local people’s attitude into consideration during conservation management strategy making to reduce human-bear conflicts and promote the coexistence of humans and bears.
Defense Mechanisms Reloaded in the Light of Impaired Personality Functioning: An Attempt of Clarification and Simplification Resulting in the DSQ-22-A for Adolescents

With the upcoming ICD-11, the diagnostic guidelines for personality disorders will change fundamentally to a dimensional severity concept, including the evaluation of several domains of personality functioning. Moreover, the lifetime perspective will allow this diagnosis even in early adolescence, providing the opportunity for early detection and intervention. In psychodynamic understanding, defense mechanisms are considered to be a part of the “personality structure”, which is one axis in the related diagnostic system (OPD) and showed great similarities to the concept of personality functioning. The most common inventory to assess defense mechanisms is the Defense Style Questionnaire, especially the DSQ-40, which has unfortunately not been specifically adapted to younger ages yet. Using an age-adapted version of the DSQ-40 with simplified formulations, a thorough empirical item analyses and selection was performed, including a face-validity check of the items by experienced therapists and assessments for item correlations, factor structure, reliability, construct and clinical validity in a german clinical and school sample containing 396 adolescents. Though several improvements, similar problems as reported for the adult DSQ versions concerning face-validity and coherence of the item pairs (2-item-method) to represent the single defense mechanisms were obtained. Thus, not all item pairs could be kept and a shortened version DSQ-22-A for adolescents with good psychometric properties was build. The three resulting defense categories adaptive, neurotic and maladaptive showed acceptable scale reliabilities (0.63, 0.56, 0.68), sound factor structure and convincing convergent and clinical validity in terms of highly significant correlations with impaired personality structure according to the OPD-CA2-SQ as well as with PHQ-D depression and somatic symptoms, especially for the maladaptive defense category (0.75, 0.44, 0.34). Likewise, the maladaptive defense category differed highly significant (p = 0.000) and with a large effect size of d = 0.9 standard deviations between adolescents from the school and the clinical sample. The DSQ-22-A can be recommended for use in adolescents for research, diagnostics and therapy planning, especially with regard to personality functioning and structure. Possible fundamental changes concerning some basic operationalization's of the defense mechanisms and the 2-item-method were suggested for international discussion.
Effects of Noisy Galvanic Vestibular Stimulation on the Muscle Activity and Joint Movements in Different Standing Postures Conditions

Objective Noisy galvanic vestibular stimulation (nGVS) is an effective method for stabilizing posture; however, little is known regarding the detailed muscle activity and joint movement in the standing posture. This study aimed to clarify the changes in the lower limb muscle activity and joint angular velocity by nGVS intervention using the simultaneous assessment method of inertial measurement units and surface electromyography (EMG). Methods Seventeen healthy participants were assessed for their physical responses under four conditions (standing on a firm surface with eyes-open/eyes-closed, and a foam surface with eyes-open/eyes-closed) without stimulation (baseline) and with stimulation (sham or nGVS). Noise stimuli were applied for 30 s at a level below the perceptual threshold. The body control response was evaluated using EMG activity and angular velocity of the lower limbs. Result Regarding the change from baseline for each parameter, there was a significant interactive effect of EMG activity in the muscle type × intervention and EMG activity and angular velocity in the condition × intervention. Post hoc analysis revealed that the angular velocity was significantly decreased in the abduction-adduction direction in the standing on a foam surface with eyes-closed condition compared to that with eyes-open in the nGVS intervention. Conclusion Our results suggest that nGVS altered physical responses in different standing postural conditions. The present study is exploratory and therefore the evidence should be investigated in future studies specifically target those muscle activities and joint motion parameters.
The Genetic Landscape of Cutaneous Lupus Erythematosus

Cutaneous lupus erythematosus (CLE) is an autoimmune connective tissue disease that can exist as a disease entity or within the context of systemic lupus erythematosus (SLE). Over the years, efforts to elucidate the genetic underpinnings of CLE and SLE have yielded a wealth of information. This review examines prior studies investigating the genetics of CLE at the DNA and RNA level and identifies future research areas. In this literature review, we examined the English language literature captured within the MEDLINE and Embase databases using pre-defined search terms. First, we surveyed studies investigating various DNA studies of CLE. We identified three predominant areas of focus in HLA profiling, complement deficiencies, and genetic polymorphisms. An increased frequency of HLA-B8 has been strongly linked to CLE. In addition, multiple genes responsible for mediating innate immune response, cell growth, apoptosis, and interferon response confer a higher risk of developing CLE, specifically TREX1 and SAMHD1. There was a strong association between C2 complement deficiency and CLE. Second, we reviewed literature studying aberrations in the transcriptomes of patients with CLE. We reviewed genetic aberrations initiated by environmental insults, and we examined the interplay of dysregulated inflammatory, apoptotic, and fibrotic pathways in the context of the pathomechanism of CLE. These current learnings will serve as the foundation for further advances in integrating personalized medicine into the care of patients with CLE.
Dynamics of Carbon Storage in Saltmarshes Across China’s Eastern Coastal Wetlands From 1987 to 2020

Saltmarsh carbon storage contributes significantly to combating global climate change and achieving regional carbon neutrality. Yet saltmarsh carbon stocks have shown a trend of decline in recent years. Therefore, long-term monitoring and analyzing of saltmarshes for their carbon storage is imperative to better protect and manage this pool of carbon. This study investigated the spatiotemporal dynamics in saltmarsh carbon storage during 1987–2020, by using the Google Earth Engine (GEE) platform and applying the Integrated Valuation of Ecosystem Services and Tradeoffs (InVEST) model, and analyzed the driving factors of carbon storage in saltmarshes. The key results are as follows. Firstly, carbon density values in saltmarshes ranged more than 14-fold, from 7.24 to 104.99 Mg·hm-2, and the total carbon storage showed a decreasing trend. Secondly, reduced carbon storage was concentrated in inshore saltmarshes adjacent to reclamation sites, especially in Shandong, whereas augmented carbon storage characterized the offshore saltmarshes dominated by Spartina alterniflora, especially in Shanghai and Jiangsu. Overall, the carbon stocks of saltmarshes have fallen by 10.44 Tg; the decrease in carbon storage caused by Suaeda salsa, Phragmites australis, and mudflats exceeded the increase in carbon storage caused by Spartina alterniflora and Scirpus mariqueter. Further, we found that reclamation was the most dominant driver of carbon storage reductions, except for sea level rise and hurricane disturbances that can also negatively impact carbon storage, while greater carbon storage was closely related to the invasion of Spartina alterniflora. This study’s findings facilitate the development of a carbon storage management strategy for saltmarsh ecosystems to address global climate change and contribute to attaining carbon neutrality.
There Is No Carbon Transfer Between Scots Pine and Pine Mistletoe but the Assimilation Capacity of the Hemiparasite Is Constrained by Host Water Use Under Dry Conditions

Pine mistletoe is a hemiparasitic shrub that can produce its own photosynthates. There is a lack of knowledge about the interaction of mistletoe and host under varying environmental condition that might influence carbon gain and allocation. In a 13C-pulse labeling experiment with mature Pinus sylvestris (pine) infected by mistletoes grown in naturally dry or irrigated conditions, (1) mistletoe clusters were shielded from 13CO2 added, and (2) mistletoes or host needles were removed to manipulate the local assimilate and water availability. No 13C signal was found in shielded mistletoes, indicating no carbon transfer from the host to the mistletoe. When the pine needles were removed from girdled branches, no 13C signal was found in the host tissues, implying no carbon transfer from mistletoe to the host. However, mistletoes on needle-removed pine trees accumulated more labeled assimilates and had higher non-structural carbohydrate (NSC) concentrations only under naturally dry conditions but not in irrigated plots. Our results suggest that mistletoes show full carbon autonomy, as they neither receive carbon from nor provide carbon resource to the host trees. Moreover, the high assimilation capacity of mistletoes seems to be constrained by the host water use under dry conditions, suggesting that drought stress is not only negatively impacting trees but also mistletoes. Therefore, we conclude that the hemiparasites live on their own in terms of carbon gain which, however, depends on the water provided by the host tree.
Clinical Coders' Perspectives on Pressure Injury Coding in Acute Care Services in Victoria, Australia

Pressure injuries (PIs) substantively impact quality of care during hospital stays, although only when they are severe or acquired as a result of the hospital stay are they reported as quality indicators. Globally, researchers have repeatedly highlighted the need to invest more in quality improvement, risk assessment, prevention, early detection, and care for PI to avoid the higher costs associated with treatment of PI. Coders' perspectives on quality assurance of the clinical coded PI data have never been investigated. This study aimed to explore challenges that hospital coders face in accurately coding and reporting PI data and subsequently, explore reasons why data sources may vary in their reporting of PI data. This article is based upon data collected as part of a multi-phase collaborative project to build capacity for optimizing PI prevention across Monash Partners health services. We have conducted 16 semi-structured phone interviews with clinical coders recruited from four participating health services located in Melbourne, Australia. One of the main findings was that hospital coders often lacked vital information in clinicians' records needed to code PI and report quality indicators accurately and highlighted the need for quality improvement processes for PI clinical documentation. Nursing documentation improvement is a vital component of the complex capacity building programs on PI prevention in acute care services and is relied on by coders. Coders reported the benefit of inter-professional collaborative workshops, where nurses and coders shared their perspectives. Collaborative workshops had the potential to improve coders' knowledge of PI classification and clinicians' understanding of what information should be included when documenting PI in the medical notes. Our findings identified three methods of quality assurance were important to coders to ensure accuracy of PI reporting: (1) training prior to initiation of coding activity and (2) continued education, and (3) audit and feedback communication about how to handle specific complex cases and complex documentation. From a behavioral perspective, most of the coders reported confidence in their own abilities and were open to changes in coding standards. Transitioning from paper-based to electronic records highlighted the need to improve training of both clinicians and coders.
Characterization of Terahertz Radiation Generated in an Organic Crystal

The terahertz region of the electromagnetic spectrum is an important research area allowing insights into fundamental science such as inter-molecular interactions, and with applications in the environmental, medical and security field. Using femtosecond lasers, it is possible to design compact and efficient terahertz generation schemes, resulting in few-cycle broadband pulses. This master thesis is concerned with generating terahertz radiation through optical rectification in the organic crystal DSTMS. This crystal has a high second order nonlinear coefficient and is phase matched for a 1500 nm pump laser. Terahertz radiation was successfully generated, with a maximum energy of 3.75 $\mu$J, corresponding to a generation efficiency of 0.71$\%$ at a pump laser energy of 530 $\mu$J. The theoretical background of this process, as well as the practical work is presented in this thesis. (Less)
Shade Delayed Flowering Phenology and Decreased Reproductive Growth of Medicago sativa L.

Alfalfa (Medicago sativa L.) is an important forage in intercropping or rotation ecosystem, and shading is the principal limiting factor for its growth under the crop or forest. Agronomic studies showed that shading would systematically reduce the biomass of alfalfa. However, little is known about the reproduction of alfalfa under shading conditions. In order to study the effect of shading on the reproductive characteristics of alfalfa, two alfalfa cultivars (“Victoria” and “Eureka”) were used to study the effect of shading levels (full light, 56.4% shade, and 78.7% shade) on alfalfa flowering phenology, pollen viability, stigma receptivity, and seed quality. Results showed that shading delayed flowering phenology, shortened the flowering stage, faded the flower colors, and significantly reduced pollen viability, stigma receptivity, the number of flowers, quantity, and quality of seeds. Under shading conditions, seed yield per plant was obviously positively correlated with germination potential, germination rate, pollen viability, and 1,000-seed weight. The number of flower buds, pollen viability, 1,000-seed weight, and germination rate had the greatest positive direct impact on seed yield per plant. Our findings suggested that delayed flowering and reducing reproduction growth were important strategies for alfalfa to cope with shading and pollen viability was the key bottleneck for the success of alfalfa reproduction under shading. However, given that alfalfa is a perennial vegetative-harvest forage, delaying flowering in a weak light environment was beneficial to maintain the high aboveground biomass of alfalfa. Therefore, this should be taken into account when breeding alfalfa cultivars suitable for intercropping. Future research should further reveal the genetic and molecular mechanism of delayed flowering regulating the accumulation and distribution of assimilates between vegetative and reproductive organs of alfalfa under shading, so as to provide a theoretical basis for breeding of shade-tolerant alfalfa cultivars.