Miracle-dz/UniFAR-FTUs huggingface dataset:
Several Factors Affecting the Occurrence of Audit Delay

This study aims to obtain empirical evidence regarding the effect of company size, solvency, company profit/loss, and KAP's reputation on audit delays in manufacturing companies listed on the Indonesia Stock Exchange. The population in this study were all manufacturing companies in the Food and Beverage Subsector, which were listed on the Indonesia Stock Exchange during the 2015-2017 period. The sample was selected based on the purposive sampling method. The selection of models used in this study were 12 companies. The data used in this study is secondary or quantitative, with data sources from financial reports audited by each company listed on the Indonesia Stock Exchange (IDX). The analytical method is the classical assumption test and multiple linear regression analysis. The study results show that company size, solvency, and KAP's reputation positively and significantly affect audit delay. In contrast, company profits/losses have a positive and insignificant impact on audit delay.
Topological phase, supercritical point and emergent fermions in the extended parafermion chain

Topological orders and associated topological protected excitations satisfying Abelian or non-Abelian statistics have been widely explored in various platforms. In recent years, the Majorana zero modes with these features have been realized in experiments based on semiconductor and superconducting hybrid structures, opening an exciting avenue for realization of fault-tolerant topological quantum computations. The $\mathbb{Z}_3$ parafermions are regarded as the most natural generation of the Majorana fermions for realizing of more intriguing topological orders. In this work, we investigate the topological phase and emergent fermions in an extended parafermion chain using exact numerical methods. This model exhibits rich variety of phases, including threefold degenerate topological ferromagnetic phase, trivial paramagnetic phase, XX phase, dimer phase, chiral phase and commensurate phase. We present a smooth connection between this model and the extended spin-${1\over 2}$ XX model, by which we can generalize their measurements, such as the order parameters and long-range spin-spin correlations {\it etc}, to fully characterize the properties of these phases and map out their corresponding phase diagram. Strikingly, we find that all the phase boundaries finally merge to a single supercritical point, determined by the extended three-state Potts model. This approach opens a wide range of intriguing applications in investigating the phases and emergent phenomena in other $\mathbb{Z}_k$ parafermion models, and may be also illuminating for their experimental realizations.
Sicilian Rivet Wheat Landraces: Grain Characteristics and Technological Quality of Flour and Bread

In recent years, the growth of tetraploid Sicilian wheat landraces has been arousing increasing interest. In this study, eighteen local genotypes of Triticum turgidum subsp. turgidum, belonging to the groups ‘Bufala’, ‘Ciciredda’, ‘Bivona’ and ‘Paola’, and two cultivars of Triticum turgidum subsp. durum (the old variety ‘Bidì’, and a more recent variety ‘Simeto’) were assessed for the characteristics of the grain and bread-making performance of their flours and doughs, as well as the quality of the loaves. The grain of the twenty genotypes came from a field trial conducted during 2018–2019 in south-eastern Sicily. The main commercial features of the grain (thousand kernel weight and hectolitre weight), including the defects (starchy, black pointed and shrunken kernels), were determined. The wholemeal flours and doughs obtained from the grain of each genotype were evaluated for the main technological quality (physico-chemical and rheological characteristics), and processed into loaves, whose main quality indices (volume, height, weight, moisture and porosity) were assessed. The results from such analyses allowed the authors to evaluate the genotypes’ bread-making suitability. In particular, for the grain characteristics, hectolitre weight varied from 68.23 (‘Bufala Rossa Lunga 01’) to 77.43 (‘Bidì 03’) kg/hL, passing through the typical values for common and durum wheat. Among the grain defects, the black point defect was absent in all the grain samples, except for that of ‘Bufala Nera Corta 01’ (2%). Dry gluten content varied from 6.22 to 10.23 g/100 g, and sedimentation test values were low or medium-low, with values ranging from 22 to 35 mL. Amylase activity was low and highly variable among the genotypes, with the maximum value observed for ‘Bufala Rossa Corta b01’ (509 s). The doughs evidenced a poor quality for bread making with alveograph values of W ranging from 12 to 145 (10−4 × Joule) and thus the volume of the loaves varied from 346.25 cm3 of ‘Bivona’ and ‘Ciciredda’ to 415.00 cm3 of ‘Bufala Rossa Lunga’. A Tandem Cluster Analysis was conducted on a set of all the response variables. The Hierarchical Cluster Analysis was initially run. A five-cluster solution identified three clusters further segmented and two single branches. Overall, the study highlighted the possibility of using some of these landraces alone for the production of traditional breads locally appreciated or together with other ingredients for the production of crumbly baked goods such as substitutes for bread and biscuits.
The German O*NET Interest Profiler Short Form

Abstract. Holland’s RIASEC model is the dominant framework to conceptualize vocational interests. It describes vocational interests with six broad domains: realistic, investigative, artistic, social, enterprising, and conventional. The O*NET Interest Profiler Short Form is a freely accessible inventory measuring vocational interests according to Holland’s model with 60 items. With this manuscript, we provide a translation of the inventory into German and evaluate the scores’ psychometric qualities, construct-related and criterion-related validity. We used data from an age-diverse ( N = 276) and high-school sample ( N = 672). Internal consistency estimates of the scale scores were adequate. Randomization tests and multidimensional scaling showed that the scores’ structural properties mirrored the RIASEC theoretical model. Scale scores were sensitive to gender differences and could predict participants’ actual and ideal occupations with reasonable hit rates. Overall, the German O*NET Interest Profiler Short Form seems apt for usage in career counseling and research settings.
The Digital Environmental Footprint - a holistic framework of Digital Sustainability

: This paper examines the different ways in which the Information and Communications Technology (ICT) sector negatively affects the environment. To capture environmental externalities beyond the common but limited carbon footprint, a novel holistic framework of digital sustainability was created - the Digital Environmental Footprint (DEF). To apply and test the DEF, the ICT sector was evaluated regarding its impacts on the sustainability dimensions of global carbon footprint, biodiversity, and availability of non-renewable resources. It was found that the production phase of digital devices has the most severe impact on these dimensions, followed by the end-of-life phase. The use phase was found to have moderate but significant impacts on sustainability that are expected to decrease over time alongside the global Carbon Intensity of Electricity (CIE). This paper emphasizes the importance of considering dimensions of digital sustainability beyond carbon footprint and the need for establishing holistic metrics for evaluating the sustainability of the ICT sector.
Adverse Childhood Experiences, Social Isolation, Job Strain, and Cardiovascular Disease Mortality in U.S. Older Employees

Stress is a key driver of cardiovascular disease (CVD), yet the contribution of psychosocial stressors to the development of CVD has not been systematically examined in United States (U.S.) populations. The objective of this study was to assess prospective associations of adverse childhood experiences (ACEs), social isolation, and job strain with CVD mortality. Data were from the large, nationally representative, population-based Health and Retirement Study (HRS). ACEs, social isolation and job strain were assessed using validated survey instruments at baseline between 2006–2008, and death information was followed up through 2018. Cox proportional hazards regression models were used to examine prospective associations of ACEs, social isolation, and job strain with CVD mortality among 4046 older employees free from CVD at baseline. During 42,149 person-years of follow-up time, 59 death cases of CVD were reported. After adjustment for covariates, ACEs and job strain were significantly associated with increased risk of CVD mortality (aHR and 95% CI = 3.67 [1.59, 8.48] and 2.24 [1.21, 4.11], respectively), whereas social isolation demonstrated an inflated but nonsignificant association (aHR and 95% CI = 1.62 [0.72, 3.66]). These findings highlight the role of psychosocial exposures as novel and clinically relevant risk factors for CVD.
Human Population Density Influences Genetic Diversity of Two Rattus Species Worldwide: A Macrogenetic Approach

On a planet experiencing constant human population growth, it is necessary to explore the anthropogenic effects on the genetic diversity of species, and specifically invasive species. Using an analysis that integrates comparative phylogeography, urban landscape genetics, macrogenetics and a systematic review, we explore the worldwide genetic diversity of the human commensal and anthropogenic species Rattus rattus and Rattus norvegicus. Based on metadata obtained considering 35 selected studies related to observed heterozygosity, measured by nuclear molecular markers (microsatellites, Single Nucleotide Polymorphisms—SNPs-, restrictition site-associated DNA sequencing -RAD-Seq-), socioeconomic and mobility anthropogenic factors were used as predictors of genetic diversity of R. rattus and R. norvegicus, using the Gini index, principal component analysis and Random Forest Regression as analysis methodology. Population density was on average the best predictor of genetic diversity in the Rattus species analyzed, indicating that the species respond in a particular way to the characteristics present in urban environments because of a combination of life history characteristics and human-mediated migration and colonization processes. To create better management and control strategies for these rodents and their associated diseases, it is necessary to fill the existing information gap in urban landscape genetics studies with more metadata repositories, with emphasis on tropical and subtropical regions of the world.
Nematodynamics and structures in junctions of cylindrical micropores

ABSTRACT We explore equilibrium structures and flow-driven deformations of nematic liquid crystals confined to 3D junctions of cylindrical micropores with homeotropic surface anchoring. The topological state of the nematic ordering field in such basic unit of porous networks is controlled by nematic orientation profiles in individual pores, anchoring frustration along the edges of joining pores and coupling to the material flow field. We numerically investigate formation of the flow-aligned configurations in single cylindrical pores and pore junctions. Depending on the arrangement of inlet and outlet flows in the junction, we demonstrate existence of numerous stationary nematic configurations, characterised by specific bulk defects and surface disclinations along joining edges. Observed bulk defects are nonsingular escaped structures, disclinations in the form of loops or disclination lines pinned to the joining edges of the pores. Furthermore, we show examples of defect dynamics during the flow-induced topological transformations. GRAPHICAL ABSTRACT
Complexation of phycocyanin with hydroxypropyl-β-cyclodextrin and its application in blue beer containing quinoa saponins as foaming agents

Introduction With the increasing importance attached to human health, the inclusion complex (IC) of phycocyanin (PC) into hydroxypropyl-β-cyclodextrin (HP-β-CD) have been devoted to developing the use of food preservation in this study. Methods In this experiment, the IC of PC into HP-β-CD was prepared by the freeze-drying method and characterized by OM, TEM, UV, FTIR and TG/DSC methods. Results and discussion The spectroscopic features were evaluated by Ultraviolet-visible (UV-vis) spectroscopy and Fourier transform infrared spectroscopy (FT-IR) confirming that PC was located in the hydrophobic cavity of HP-β-CD. Consistent with the structural properties, optical microscopy (OM) and Transmission electron microscope (TEM) observed that the addition of PC subjected the IC to an aggregation state with irregular lamellar structures. Stability assessment showed that pH, heat and light tolerance of PC significantly regulated and improved due to the PC/HP-β-CD complexation. The formation of ICs was helpful to enhancing the antioxidant activity of PC. Molecular modeling suggested that the D-pyrrole ring and its associated C=C group of phycocyanin entered the HP-β-CD cavity from the wider edge. On this basis, the development of blue beer with quinoa saponins as foaming agent and ICs as colorant was explored. The addition of quinoa saponins made the foam richer and more delicate without destroying the overall taste coordination of beer. Moreover, the protective effect of HP-β-CD presents a positive impact on the stability of blue beer pigment. Hence, PC encapsulated into HP-β-CD will be an impressive approach in food-related application of PC.
Neutrophil Extracellular Traps Drive Dacryolithiasis

Mucopeptide concretions, previously called dacryoliths, are macroscopic stones that commonly obstruct the lacrimal sac. The mechanism behind dacryolithiasis remains unclear; however, the involvement of various immune cells, including neutrophils, has been confirmed. These findings remain limited, and no information on neutrophil extracellular traps (NETs), essentially involved in the pathogenesis of other lithiases, is available yet. Here, we employ microcomputed tomography, magnetic resonance tomography, histochemistry, mass spectrometry, and enzyme activity analyses to investigate the role of neutrophils and NETs in dacryolithiasis. We classify mucopeptide concretions into three types, with respect to the quantity of cellular and acellular material, polysaccharides, and mucosubstances. We propose the role of neutrophils and NETs within the existing model of gradual formation and growth of mucopeptide concretions, with neutrophils contributing to the initial stages of dacryolithiasis, as they localized on the inner (older) parts of the tissue. As NETs localized on the outer (newer) parts of the tissue, we link their role to the late stages of dacryolithiasis, presumably maintaining the proinflammatory environment and preventing efficient clearance. An abundance of IgG on the surface indicates the involvement of the adaptive immune system later as well. These findings bring new perspectives on dacryolithiasis, in which the innate and adaptive immune system are essentially involved.
Serology Identifies LIPyV as a Feline Rather than a Human Polyomavirus

The number of identified human polyomaviruses (HPyVs) has increased steadily over the last decade. Some of the novel HPyVs have been shown to cause disease in immunocompromised individuals. The Lyon-IARC polyomavirus (LIPyV) belonging to species Alphapolyomavirus quardecihominis was identified in 2017 in skin and saliva samples from healthy individuals. Since its initial discovery, LIPyV has rarely been detected in human clinical samples but has been detected in faeces from cats with diarrhoea. Serological studies show low LIPyV seroprevalence in human populations. To investigate the possibility that LIPyV is a feline rather than a human polyomavirus, we compared serum IgG responses against the VP1 major capsid protein of LIPyV and 13 other HPyVs among cats (n = 40), dogs (n = 38) and humans (n = 87) using an in-house immunoassay. Seropositivity among cats was very high (92.5%) compared to dogs (31.6%) and humans (2.3%). Furthermore, the median antibody titres against LIPyV were 100–10,000x higher in cats compared to dogs and humans. In conclusion, the high prevalence and intensity of measured seroresponses suggest LIPyV to be a feline rather than a human polyomavirus. Whether LIPyV infection induces diarrhoea or other symptoms in cats remains to be established.
MOLECULAR AND ENZYMATIC RESISTANCE OF CULEX TARSALIS TO PYRETHROID AND ORGANOPHOSPHATE INSECTICIDES

By Billy Michael Mortola University of the Pacific 2023 Culex tarsalis, a vector for diseases like West Nile virus, is evolving resistance to pyrethroid and organophosphate insecticides used for agriculture and vector control in Northern California. Common mechanisms of resistance in other Culex species include the target-site mutations kdr and ace-1 and increased levels of detoxification enzymes (esterases, GSTs, and oxidases). This study contained two parts: Pyrethroid Individual study and an Organophosphate Preliminary study. For the Pyrethroid Individual study, the goal was to compare the prevalence of kdr mutations and detoxification enzymes between pyrethroid susceptible and resistant Cx. tarsalis individuals in Northern California. For the Organophosphate Preliminary study, the goal was to survey current organophosphate resistance in Northern California Cx. tarsalis populations while identifying possible resistance mechanisms: ace-1 and variations in detoxification enzymes between populations and individuals. Individual mosquitoes previously categorized by resistance status from CDC bottle bioassays with permethrin or naled were prepared for both molecular and enzymatic testing by separating the legs of a mosquito from the remaining body. Legs were used to test for the presence of kdr and ace-1 mutation by qPCR and PCR respectively and confirmed by DNA sequencing while the bodies were used to test for levels of detoxification enzymes. A subset of individuals in the Organophosphate Preliminary study forwent bottle 5 bioassays and were tested directly to make comparisons between populations without the stress of going into bottle bioassays. For the Pyrethroid Individual study, the greater number of F alleles present at the kdr target-site as well as increased levels of GST significantly increased survival when exposed to permethrin. Individuals with 2 F alleles and an active GST level greater than or equal to 0.052 ug/ml showed a higher survival rate than either mechanism independently demonstrating resistance to pyrethroids in Cx. tarsalis is likely the result of multiple resistance mechanisms acting collectively. For the Organophosphate Preliminary study, currently little resistance to naled (3%) was observed in Northern California Cx. tarsalis populations. No ace-1 mutations were found in the 208 individuals tested, however three did possess silent mutations at the target-site, suggesting surveillance is needed in the future. Between the small sample size and little resistance found in this preliminary study, there was no correlation between levels of detoxification enzymes from resistant and susceptible individuals. Due to differences in the biology of Cx. tarsalis and other mechanisms of resistance not looked at in this study it is hard to quantify definitive resistance mechanisms in Cx. tarsalis. From this study it appears that kdr mutation (L1014F) and increased levels of GST likely contribute at some level to resistance to pyrethroid insecticides in Cx. tarsalis.
Estimating summer sea ice extent in the Weddell Sea during the early 19th century

Abstract. Over the past 3 decades, discordant trends in sea ice extent have been observed between the Arctic and Antarctic regions. Arctic sea ice extent has been characterised by a rapid decline, whereas Antarctic sea ice extent, while highly variable interannually, has tended to increase. Climate models have so far failed to capture these trends. Coupled with the limited pre-1970 sea ice dataset, this poses a significant challenge to quantifying the mechanisms responsible for driving such trends. However, historical records from early Antarctic expeditions contain a wealth of information regarding the nature and concentration of sea ice. Such records have been underutilised, and their analysis may enhance our understanding of recent Antarctic sea ice variability. For the purpose of this study, nine records from eight Antarctic expeditions have been examined. Summer sea ice positions recorded during 1820–1843 have been compared to satellite observations from 1987–2017, as well as historical data for the period 1897–1917. Through analysis of these three time series, estimates for the northern limits of summer sea ice in the Weddell Sea during the early 19th century have been produced. The key findings of this study indicate a 19th century average core summer northernmost sea ice latitude in much of the Weddell Sea that was further north than during the modern era, with 19th century February having significantly more sea ice by all measures. However, late summer sea ice was most extensive in the early years of the 20th century.
Reconstructing atmospheric H2 over the past century from bi-polar firn air records

Abstract. Historical atmospheric H2 levels were reconstructed using firn air measurements from two sites in Greenland (NEEM and Summit) and two sites in Antarctica (South Pole and Megadunes). A joint reconstruction based on the two Antarctic sites yields H2 levels monotonically increasing from about 330 ppb in 1900 to 550 ppb in the late 1990s, leveling off thereafter. These results are similar to individual reconstructions published previously (Patterson et al., 2020, 2021). Interpretation of the Greenland firn air measurements is complicated by challenges in modeling enrichment induced by pore close-off at these sites. We used observations of neon enrichment at NEEM and Summit to tune the parameterization of enrichment induced by pore close-off in our firn air model. The joint reconstruction from the Greenland data shows H2 levels rising 30 % between 1950 and the late 1980s, reaching a maximum of 530 ppb. After 1990, reconstructed atmospheric H2 levels over Greenland are roughly constant, with a small decline of 3 % over the next 25 years. The reconstruction shows good agreement with the available flask measurements of H2 at high northern latitudes.
CONTINUOUS CUFFLESS BLOOD PRESSURE MEASUREMENT

(ECG) and photoplethysmography (PPG) signals without a cuff and calibration procedure . The novelty of this work is the discovery of five new key points of the PPG signal, as well as the calculation of nine new features of the ECG and PPG signals, which improve the accuracy of blood pressure measurement. The object of the study was the ECG and PPG signals recorded from the patient's hand. The target of the study was to obtain systolic and diastolic blood pressure based on an FFNN, the input arguments of which are the parameters of the ECG and PPG signals. Algorithms for estimating signal parameters based on the determination of characteristic points in the PPG signal, the position of R-peaks in the ECG signal, and parameters calculated from the relationship of time parameters and amplitude ratios of these signals are described in detail. The Pearson correlation coefficients for these parameters and BP are determined, which helps to choose the set of signal parameters valuable for BP estimation. The results obtained show that the mean absolute error ± standard deviation for systolic and diastolic BP is equal to 1.72±3.008 mmHg and 1.101±1.9 mmHg, respectively; the correlation coefficients for the estimated and true BP are equal to 0.94. Conclusions . The model corresponds to the AAMI standard and the “A” grade in the BHS standard, which proves the high accuracy of BP assessment by the proposed approach. Comparison to other known methods was performed, which confirmed the advantages of the proposed approach.