Miracle-dz/UniFAR-FTUs huggingface dataset:
COVID-19 symptoms at time of testing and association with positivity among outpatients tested for SARS-CoV-2

Introduction Symptoms associated with SARS-CoV-2 infection remain incompletely understood, especially among ambulatory, non-hospitalized individuals. With host factors, symptoms predictive of SARS-CoV-2 could be used to guide testing and intervention strategies. Methods Between March 16 and September 3, 2020, we examined the characteristics and symptoms reported by individuals presenting to a large outpatient testing program in the Southeastern US for nasopharyngeal SARS-CoV-2 RNA RT-PCR testing. Using self-reported symptoms, demographic characteristics, and exposure and travel histories, we identified the variables associated with testing positive using modified Poisson regression. Results Among 20,177 tested individuals, the proportion positive was 9.4% (95% CI, 9.0–9.8) and was higher for men, younger individuals, and racial/ethnic minorities (all P<0.05); the positivity proportion was higher for Hispanics (26.9%; 95% CI. 24.9–29.0) compared to Blacks (8.6%; 95% CI, 7.6–9.7) or Whites (5.8%; 95% CI, 5.4–6.3). Individuals reporting contact with a COVID-19 case had the highest positivity proportion (22.8%; 95% CI, 21.5–24.1). Among the subset of 8,522 symptomatic adults who presented for testing after May 1, when complete symptom assessments were performed, SARS-CoV-2 RNA PCR was detected in 1,116 (13.1%). Of the reported symptoms, loss of taste or smell was most strongly associated with SARS-CoV-2 RNA detection with an adjusted risk ratio of 3.88 (95% CI, 3.46–4.35). The presence of chills, fever, cough, aches, headache, fatigue and nasal congestion also significantly increased the risk of detecting SARS-CoV-2 RNA, while diarrhea or nausea/vomiting, although not uncommon, were significantly more common in those with a negative test result. Symptom combinations were frequent with 67.9% experiencing ≥4 symptoms, including 19.8% with ≥8 symptoms; report of greater than three symptoms increased the risk of SARS-CoV-2 RNA detection. Conclusions In a large outpatient population in the Southeastern US, several symptoms, most notably loss of taste or smell, and greater symptom burden were associated with detection of SARS-CoV-2 RNA. Persons of color and those with who were a contact of a COVID-19 case were also more likely to test positive. These findings suggest that, given limited SARS-CoV-2 testing capacity, symptom presentation and host characteristics can be used to guide testing and intervention prioritization.
Age-Based Anthropometric Cutoffs Provide Inconsistent Estimates of Undernutrition: Findings from a Cross-Sectional Assessment of Late-Adolescent and Young Women in Rural Pakistan

ABSTRACT Ambiguity around age ranges for adolescence and adulthood can make the application of age-based nutrition cutoffs confusing. We examined how estimates generated using the age-based anthropometric cutoffs for adolescent girls (10 to <19 y) and women of reproductive age (15–49 y) compared between late-adolescent and young women, and determined how application of both cutoffs affected late-adolescents’ estimates. Using cross-sectional data from participants aged 15–23 y in the Pakistan-based Matiari emPowerment and Preconception Supplementation (MaPPS) Trial (n = 25,447), notably large differences in estimates were observed for stunting (30.5% and 7.9% for late-adolescent and young women, respectively; P < 0.001) and thinness (9.3% and 30.8%, respectively; P < 0.001). When both cutoffs were applied to adolescents’ data, estimate differences were maintained. With each year of age, the difference for stunting increased and thinness decreased. Given the discrepancies observed both between and within groups, clarity around application of anthropometric cutoffs for youth (aged 15–24 y) is needed. This trial was registered at clinicaltrials.gov as NCT03287882.
Factors inducing knowledge creation: empirical evidence from Thai construction projects

Purpose – This research is aimed at examining the relationships between knowledge factors and the knowledge creation process in construction projects, paying particular attention to on‐site work.Design/methodology/approach – The design of this research is cross‐sectional and uses a blended methodological approach of both quantitative and qualitative methods. The research model includes the following variables; six knowledge factors: vision of leadership, trust, collaboration, incentives, information technology (IT) support, and individual competencies; and four knowledge creation processes: socialization, externalization, combination, and internalization. Survey data from 70 construction projects in Thai construction firms, obtained by means of a questionnaire developed by the researcher, were collated and analyzed. As a means of testing the model, regression analysis techniques were used to analyze the data.Findings – Consistent with previous empirical evidence, three knowledge factors affected the knowl.
Triple Estimation of Fractional Variable Order, Parameters, and State Variables Based on the Unscented Fractional Order Kalman Filter

In this paper, a method for states, parameters, and fractional order estimation is presented. The proposed method is an extension of the traditional dual estimation method and uses three blocks of filters with appropriate data interconnections. As the main part of the estimation algorithm, the Fractional Unscented Kalman Filter was used. The proposed Triple Estimation algorithm might be treated as a convenient tool for estimation and analysis of a wide range of dynamical systems with fractional constants or variable order nature, especially when knowledge about the identified system is very restricted and both order and system parameters are unknown. In order to show the performance of the proposed algorithm, sets of numerical results are presented.
Association between temporal summation and conditioned pain modulation in chronic low back pain: baseline results from 2 clinical trials

Supplemental Digital Content is Available in the Text. In chronic low back pain, the modest association between temporal summation and conditioned pain modulation suggests that they approximate relatively independent physiological processes and supports independent assessment of both measures. Abstract Introduction: Temporal summation (TS) and conditioned pain modulation (CPM) represent different aspects of central pain processing. Their relationship and differential performance within distinct body locations are not well understood. Objectives: To examine the association between TS and CPM in chronic low back pain and the influence of testing location on this relationship. Methods: We analyzed baseline data from 2 clinical trials on participants with chronic low back pain (n = 264; 47.3% female; mean age = 41 years, SD = 12; mean pain = 5.3/10, SD = 1.4). Measures used included questionnaires assessing pain and negative affect, phasic thermal TS at the hand (thenar) and the lower back (lumbar), followed by CPM that included a thermal testing stimulus (Heat-6, the temperature where pain rating is 6/10) and a cold-pressor conditioning stimulus. Nonparametric, proportional odds logistic regression was used to model thenar, and separately, lumbar TS, using CPM, Heat-6, negative affect, and demographics. Results: Our models revealed a small association (βs = 0.17, P = 0.01) between reduced CPM and heightened TS at both testing sites, regardless of demographics or negative affect. Conclusion: Results suggest a modest association between TS and CPM, irrespective of anatomical testing location, demographics, and negative affect. These findings will help improve the methodology and interpretation of TS and CPM measurement in clinical pain populations.
Influence of finite ground conductivity on the fields of a vertical traveling wave of current

Following Wait (1998), we deal mainly with the radiation fields of a vertically directed and attenuated line current (lightning) above a plane Earth. In the present case, the conductivity and permittivity of the ground modify the radiation pattern in the air compared with the usually assumed case of infinite conductivity. The effect is quite striking at low elevation angles where the radiation pattern now has a null for grazing angles.
AJA2000085 43..66

Purpose: This dual-aim study was intended to develop and validate a new fitting paradigm for over-the-counter (OTC) hearing aids. Aim 1 was undertaken to create a limited set of evidence-based preconfigured gain–frequency responses (“presets”) for use in OTC devices. Aim 2 tested the efficacy of the presets relative to best-practice verification and determined the best method(s) for older adults to selfselect amplification from the set. Method: In Aim 1, audiometry data from 267 older adults with mild-to-moderate sensorineural hearing loss were obtained from the National Health and Nutrition Examination Survey database. Using these data and the National Acoustic Laboratories–Non-Linear 2 (NAL-NL2) prescriptive formula, a set of four presets were created that can fit a large percentage of older Americans with presbycusis. In Aim 2, 37 older adults with hearing loss used five methods to select presets. The selection methods were select-by-audiogram, select-by-
Influence of Hysteretic Behavior on Equivalent Period and Damping of Structural Systems

Relations for the equivalent period \iT\Deq\N and equivalent damping ratio ζ\Deq\N for the equivalent linear system approach for seismic design are proposed. These relations are based on optimal \iT\Deq\N and ζeq values derived from extensive time-history analyses of single-degree-of-freedom systems with six types of hysteretic behavior and a period range of 0.1 to 1.5 s. The proposed relations are more general (in their applicability to a wide range of hysteretic systems) and have stronger ties to physical behavior compared to existing empirical methods for evaluating \iT\Deq\N and ζ\Deq\N. The proposed relations address differences in equivalent stiffness resulting from different hysteretic behavior. Simulations show that the optimal \iT\Deq\N, associated with the stiffness of the partial load-displacement cycles of a hysteretic system, is the highest for the slip system (with a zero unloading/reloading stiffness) and the lowest for the bilinear elastic system (with an elastic unloading/reloading stiffness). The optimal ζ\Deq\N, associated with the energy dissipation capacity of a hysteretic system, is the highest for the elastoplastic system and the lowest for the bilinear elastic system.
Efficacy of anti-SARS-CoV-2 mRNA vaccine in systemic autoimmune disorders: induction of high avidity and neutralising anti-RBD antibodies

Objectives In patients with systemic autoimmune rheumatic disorders (SARDs), vaccination with SARS-CoV-2 mRNA vaccines has been proposed. The aim of this study is to evaluate the immune response elicited by vaccination with mRNA vaccine, testing IgM, IgA and IgG antibodies to SARS-CoV-2 receptor-binding domain (RBD) and measuring neutralising antibodies. Methods IgG, IgM and IgA anti-RBD antibodies were measured in 101 patients with SARDs. Antibodies inhibiting the interaction between RBD and ACE2 were evaluated. Antibody avidity was tested in a chaotropic ELISA using urea. Twenty-one healthcare workers vaccinated with mRNA vaccine served as control group. Results Anti-RBD IgG and IgA were produced after the first dose (69% and 64% of the patients) and after the boost (93% and 83%). Antibodies inhibiting the interaction of RBD with ACE2 were detectable in 40% of the patients after the first dose and 87% after boost, compared with 100% in healthy controls (p<0.01). Abatacept and mycophenolate had an impact on the titre of IgG anti-RBD antibodies (p<0.05 and p<0.005, respectively) and on the amount of neutralising antibodies. No effect of other therapies was observed. Vaccinated patients produce high avidity antibodies, as healthy controls. Conclusions These data show that double-dose vaccination induced in patients with SARDs anti-RBD IgG and IgA antibodies in amounts not significantly different from controls, and, most interestingly, characterised by high avidity and endowed with neutralising activity.
Serum levels of proinflammatory cytokines and selected bioelements in perimenopausal women with regard to body mass index

During the menopause, decreased estrogen levels may be accompanied by increased levels of inflammatory mediators. Many studies also show significant relationships between the levels of bioelements and proinflammatory cytokines. The aim of this study was to assess the levels of proinflammatory cytokines, C-reactive protein (CRP), and selected bioelements in perimenopausal women with regard to BMI. Methods: The study of 217 perimenopausal women involved the completion of questionnaires concerning sociodemographic and medical data, anthropometric measurements, and blood collection. Results: In all studied women, the levels of IL-1β significantly positively correlated with Ca, Mg, and Sr; IFNγ significantly negatively correlated with Sr, and IL-6 with Mg. In women with a normal BMI, the levels of IL-1β significantly positively correlated with Ca and Sr, and CRP positively correlated with Zn. In overweight women, the levels of IL-1β positively correlated with Ca, IL-6 with Na, and IFNγ negatively correlated with Sr. In obese women, the levels of CRP positively correlated with Zn, TNFα with Mg, IFNγ with Cu and P. The levels of IL-6 negatively correlated with Ca and Mg. Conclusions: BMI may be one of the factors that affect the relationship between serum bioelement levels and the levels of proinflammatory cytokines and CRP in women, especially during the menopausal period.
Acoustic Features of Oral Reading Prosody and the Relation With Reading Fluency and Reading Comprehension in Taiwanese Children.

PURPOSE The study aimed to examine whether oral reading prosody-the use of acoustic features (e.g., pitch and duration variations) when reading passages aloud-predicts reading fluency and comprehension abilities. METHOD We measured vocabulary, syntax, word reading, reading fluency (including rate and accuracy), reading comprehension (in Grades 3 and 4), and oral reading prosody in Taiwanese third-grade children (N = 109). In the oral reading prosody task, children were asked to read aloud a passage designed for third graders and then to answer forced-choice questions. Their oral reading prosody was measured through acoustic analyses including the number of pause intrusions, intersentential pause duration, phrase-final comma pause duration, child-adult pitch match, and sentence-final pitch change. RESULTS Analyses of variance revealed that children's number of pause intrusions differed as a function of word reading. After controlling for age, vocabulary and syntactic knowledge, and word reading, we found that different dimensions of oral reading prosody contributed to reading rate. In contrast, the number of pause intrusions, phrase-final comma pause duration, and child-adult pitch match predicted reading accuracy and comprehension. CONCLUSIONS Oral reading prosody plays an important role in children's reading fluency and reading comprehension in tone languages like Mandarin. Specifically, children need to read texts prosodically as evidenced by fewer pause intrusions, shorter phrase-final comma pause duration, and closer child-adult pitch match, which are early predictive makers of reading fluency and comprehension.
Government-to-Citizens Relationship: Evaluating the Quality of Information on Saudi Ministries' Websites

The government is an important provider of information to citizens. The provision of government information, as part of the Government-to-Citizens relationship in e-Government implementation, is necessary for enhancing the level of government transparency and increasing citizens’ awareness. In Saudi Arabia, Saudi ministries are the main government information providers to citizens but those citizens often encounter barriers in accessing government information due to various factors, including the geographical ones. As part of the efforts that Saudi Arabia has undertaken to enhance the government-to-citizen relationship, the government has sponsored a variety of e-Government initiatives as a means of improving daily communication with Saudi citizens, and thus the government has started to embrace the World Wide Web (WWW) for delivering government information to citizens. The purpose of this paper is to assess the quality of the web-based information available on Saudi ministry websites. This paper begins by exploring the assessment framework used to assess web-based information content on Saudi ministry websites. It then sheds light on previous assessment studies conducted in 2003 and 2005 on web-based information content of Saudi ministry websites before assessing ministry websites in the beginning of 2007, using the same framework as used on the previous studies. It concludes by discussing the progress with regards to government information provision on the Saudi ministries’ websites.
Disposal habits and microbial load of solid medical waste in sub-district healthcare facilities and households in Yilo-Krobo municipality, Ghana

The study aimed to assess disposal practices and quantify the microbial load present in SMW from ten sub-district level healthcare facilities and 385 households in Yilo Krobo municipality, Ghana. Disposal of solid medical waste (SMW) was assessed by questionnaire-based surveys, unstructured interviews and field observations. Microbiological analysis identified species and counts of bacteria present in SMW from both sources. Sociodemographic factors influencing the method of SMW disposal in households were evaluated using logistic regression analysis, with statistical significance set at p<0.05. Open burning (29%), burying (25%) and disposal at a dumpsite (49%) were common methods used by households to discard SMW. SMW disposal at a dumpsite was associated with age of respondents in households. Older people (50+ years) were three times more likely to place SMW in household waste later discarded at a dumpsite, compared to younger persons (20–30 years) [a0R, 95%CI = 3.37, 1.41–8.02]. In sub-district level healthcare facilities, open burning and burying were the most common methods used. Bacillus subtilis, Klebsiella pneumonia, Pseudomonas aeruginosa, Clostridium tetani, Enterococcus faecalis, Acinetobacter spp. Escherichia coli, Bacillus cereus and Enterococcus faecium) were bacteria identified in SMW recovered from both the healthcare facilities and the households. Klebsiella pneumoniae, Acinetobacter spp. and Clostridium tetani were found exclusively in untreated SMW generated in the healthcare facilities. Bacillus spp. and Pseudomonas spp. were found in one sample of treated SMW. The microbial load in SMW from healthcare facilities and households ranged from 0.036 x 103cfc/mg to 0.167 x 103 cfc/mg and from 0.118 x 103cfc/mg to 0.125 x 103cfc/mg respectively. This highlights the need for institutionalizing appropriate treatment methods in sub-district level facilities or strengthening the linkages with higher level facilities to ensure regular and adequate treatment of SMW. Public guidance on management of SMW generated in households which is context specific should also be provided.
Structural behaviour and deformation patterns in loaded plain concrete ground‐supported slabs

The work presented in this paper is considered to be an attempt to contribute towards a better understanding of the structural behaviour of plain concrete slabs under step loading conditions. The Concrete Society Technical Report TR34 “Concrete Industrial Ground Floors” is in its 3rd edition (2003) and is currently under review. TR34 covers the design of concrete ground‐supported slabs containing fibres, both steel and synthetic, as an alternative to mesh reinforcement. This work reports on tests carried out at different critical loading locations, including the centre, edges and corners of a 6.0 × 6.0 × 0.15 m deep plain concrete slab. The test results are compared with theoretical values derived using available design codes and other information sources. The results show a notable difference between the test results and the theoretical values.
Grouped-seq for integrated phenotypic and transcriptomic screening of patient-derived tumor organoids

Abstract Patient-derived tumor organoids (PDOs) have emerged as a reliable in vitro model for drug discovery. However, RNA sequencing-based analysis of PDOs treated with drugs has not been realized in a high-throughput format due to the limited quantity of organoids. Here, we translated a newly developed pooled RNA-seq methodology onto a superhydrophobic microwell array chip to realize an assay of genome-wide RNA output unified with phenotypic data (Grouped-seq). Over 10-fold reduction of sample and reagent consumption together with a new ligation-based barcode synthesis method lowers the cost to ∼$2 per RNA-seq sample. Patient-derived colorectal cancer (CRC) organoids with a number of 10 organoids per microwell were treated with four anti-CRC drugs across eight doses and analyzed by the Grouped-seq. Using a phenotype-assisted pathway enrichment analysis (PAPEA) method, the mechanism of actions of the drugs were correctly derived, illustrating the great potential of Grouped-seq for pharmacological screening with tumor organoids.
Persister control by leveraging dormancy associated reduction of antibiotic efflux

Persistent bacterial infections do not respond to current antibiotic treatments and thus present a great medical challenge. These conditions have been linked to the formation of dormant subpopulations of bacteria, known as persister cells, that are growth-arrested and highly tolerant to conventional antibiotics. Here, we report a new strategy of persister control and demonstrate that minocycline, an amphiphilic antibiotic that does not require active transport to penetrate bacterial membranes, is effective in killing Escherichia coli persister cells [by 70.8 ± 5.9% (0.53 log) at 100 μg/mL], while being ineffective in killing normal cells. Further mechanistic studies revealed that persister cells have reduced drug efflux and accumulate more minocycline than normal cells, leading to effective killing of this dormant subpopulation upon wake-up. Consistently, eravacycline, which also targets the ribosome but has a stronger binding affinity than minocycline, kills persister cells by 3 logs when treated at 100 μg/mL. In summary, the findings of this study reveal that while dormancy is a well-known cause of antibiotic tolerance, it also provides an Achilles’ heel for controlling persister cells by leveraging dormancy associated reduction of drug efflux.