Miracle-dz/UniFAR-FTUs huggingface dataset:
Osteopontin promotes cancer cell drug resistance, invasion, and lactate production and is associated with poor outcome of patients with advanced non-small-cell lung cancer

Background: Osteopontin (OPN), a member of the small integrin binding ligand N-linked glycoprotein family, has been analyzed in numerous types of human malignancy. Purpose: The present study detected the expression levels of OPN and evaluated its role in tumor progression in patients with non-small cell lung cancer (NSCLC). Patients and methods: OPN expression levels were detected using immunohistochemistry in 101 NSCLC tumors. The mRNA and protein levels have significant difference between advanced NSCLC and stage I/II NSCLC. The drug resistance, invasive ability and lactate production of NSCLC cancer cell lines (A549 and SK-MES-1) were detected in cancer cells with the disturbance of OPN. Results: Immunostaining indicated that OPN was primarily expressed in the cytoplasm of NSCLC cells. Moreover, OPN correlates with NSCLC clinical traits. The results demonstrated that OPN expression levels significantly correlated with cancer differentiation, distant metastasis and the efficacy of platinum-based treatment. Notably, the results identified OPN expression levels as a potential factor for predicting the response of cells to first-line platinum-based chemotherapy using multivariate analysis, as well as predicting cancer differentiation and distant metastasis. Additionally, the abrogation of OPN levels reduced lactate production in NSCLC cells and occurred along side with the downregulation of lactate dehydrogenase A (LDHA). Conclusion: The results of the current study suggest that OPN may be able to predict poor prognosis and cisplatin resistance in patients.
Smoking Cessation During Pregnancy: Thoughts Expressed During Motivational Interviewing

Background: While underserved pregnant women smoke for many of the same reasons as smokers in general, there are other factors contributing to higher smoking prevalence. Health interventions require an understanding of the problem if they are to be appropriately targeted and effective. Aims: To assess barriers, facilitators and motivators of participants from the New England SCRIPT smoking cessation study who were trying to or recently quit smoking during pregnancy. Methods: Pregnant participants recruited from prenatal clinics were randomized into one of three groups comparing the effectiveness of smoking cessation interventions differing in complexity and cost. Responses from motivational interviewing calls of 227 women were coded and tallied as a percent of respondents. Smokers were queried about perceptions of health risks, pros and cons, and benefits of quitting. Recent quitters were asked why they quit; benefits since quitting; difficulties/urges anticipated; and plans for not smoking. Results: Health concerns of mothers and infants were cited as a benefit to quitting. Barriers to quitting included stress reduction, weight issues, and social acceptance. Unique facilitators and/or benefits included self-talk, prayer, self- will and weight gain. Discussion: Some of these findings mirrored previous research. However, participants who quit smoking during pregnancy did not mention weight concerns as a barrier to maintenance, and reported new and useful facilitators. Conclusions: Data collected during this MI counseling study supports and expands other qualitative literature of smoking cessation processes among pregnant women, and may help inform the development of new interventions to appropriately support this population. and after pregnancy, a comprehensive understanding of the scope of the problems they face is needed. Although qualitative studies have been conducted exploring potential barriers, many of the studies have been small, have been based on purposive samples, or examined select barriers [15,16]. Recently, Fleming et al. conducted a qualitative systematic review synthesizing findings from 38 studies that examined barriers and facilitators to smoking cessation experienced by women during and after pregnancy [17]. They highlighted the preponderance of barriers over facilitators for disadvantaged pregnant smokers to help assist with development of policy and practice [17]. Qualitative studies have increased our understanding of barriers to quitting faced by underserved pregnant women. However, additional research is needed to further expand our understanding of this complex, challenging and changing issues. To better understand barriers preventing this subgroup of pregnant smokers to quit smoking, we were interested in examining the
CMAR_A_223021 9017..9024

Xuejuan Gao* Junjie Zhu* Linsong Chen* Yan Jiang Xiao Zhou Jianwei Shuai Yanfeng Zhao 1Department of Physics, Xiamen University, Xiamen, People’s Republic of China; 2Department of Thoracic Surgery, Shanghai Pulmonary Hospital Affiliated to Tongji University, Shanghai, People’s Republic of China; 3State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, Xiamen University, Xiamen, People’s Republic of China
広島大学学術情報リポジトリ Hiroshima University Institutional Repository Title Early Visual Perception Potentiated by Object Affordances : Evidence From a Temporal Order Judgment Task

Perceived objects automatically potentiate afforded action. Object affordances also facilitate perception of such objects, and this occurrence is known as the affordance effect. This study examined whether object affordances facilitate the initial visual processing stage, or perceptual entry processes, using the temporal order judgment task. The onset of the graspable (righthandled) coffee cup was perceived earlier than that of the less graspable (left-handled) cup for right-handed participants. The affordance effect was eliminated when the coffee cups were inverted, which presumably conveyed less affordance information. These results suggest that objects preattentively potentiate the perceptual entry processes in response to their affordances.
Disrupted resting-state spontaneous neural activity in stable COPD

Introduction aim: Abnormal brain structure and function in COPD has been reported on MRI. However, the deficit in local synchronization of spontaneous activity in patients with stable COPD remains unknown. The main aim of the present study was to explore spontaneous brain activity in patients with COPD compared with normal controls using the regional homogeneity (ReHo) method based on resting-state functional MRI. Methods: Nineteen patients with stable COPD and 20 well-matched (including age, sex, and number of years of education) normal controls who were recruited for the present study underwent resting-state functional MRI examinations and a series of neuropsychological and clinical assessments. The ReHo method was used to assess the strength of local brain signal synchrony. The mean ReHo values in brain areas with abnormal ReHo were evaluated with a receiver operating characteristic curve. The relationships between the brain regions with altered ReHo values and the clinical and neuropsychological parameters in COPD patients were assessed using Pearson’s correlation. Results: Patients with COPD showed significantly lower ReHo values in the left occipital lobe and the right lingual, bilateral precuneus, and right precentral gyrus. The result of receiver operating characteristic curve analysis showed that the altered average ReHo values have high efficacy for distinguishing function. The mean lower ReHo values in the precuneus gyrus showed a significant positive correlation with FEV 1 %, FEV 1 /FVC, and orientation function but a significant negative correlation with arterial partial pressure of carbon dioxide. Conclusion: The COPD patients demonstrated abnormal synchrony of regional spontaneous activity, and the regions with abnormal activity were all correlated with visual processing pathways, which might provide us with a new perspective to further understand the underlying pathophysiology of cognitive impairment in patients with COPD. COPD patients.
Adherence to diabetes medication among diabetic patients in the Bisha governorate of saudi Arabia – a cross-sectional survey

Background: Patients’ non-adherence to diabetes medication is associated with poor glycemic control and suboptimal benefits from their prescribed medication, which can lead to worsening of medical condition, development of comorbidities, reduced quality of life, elevated health care costs, and increased mortality. Objective: This study aimed to assess medication adherence among patients with diabetes and associated factors in Bisha primary health care centers (PHCCs) in Saudi Arabia. Patients and methods: A cross-sectional study was conducted with a sample of 375 type 1 and 2 Saudi diabetic patients attending PHCCs under the Health Affairs of the Bisha governorate. The participants were aged 18 years and above, and had been taking diabetes medications for at least 3 months. Pregnant women, patients with mental illnesses, and those who were not willing to participate were excluded. Adherence to diabetes medications was measured using the four-item Morisky Green Levine Medication Adherence Scale (MGLS). All participants completed a self-report questionnaire including sociodemographic and clinical variables. Univariate and multivariate analyses were carried out using SPSS version 22. Results: Of all the respondents, 134 (35.7%), 161 (42.9%), and 80 (21.4%), patients had high (MGLS score 0), intermediate (MGLS score 1 or 2), and low adherence (MGLS score $ 3), respectively. Factors associated with the level of adherence in univariate analysis were occupational status ( P = 0.037), current medication ( P , 0.001), glycated hemoglobin (A1c) ( P , 0.001), and number of associated comorbidities ( P , 0.001). In multivariable analyses, A1c , 7 ( P , 0.001) and no associated comorbidities ( P , 0.003) variables remained significantly associated with adherence. Conclusion: The level of adherence to medication in diabetes mellitus patients in the Bisha PHCCs was found to be suboptimal. The findings point toward the need for better management of primary health care providers’ approaches to individual patients, by taking into account their medication adherence levels. Better identification of patients’ level of adherence remains essential for successful diabetes treatment. retinopathy, foot
relationship between abnormal glucose metabolism and osteoporosis in han Chinese men over the age of 50 years

Aim: The aim of this study was to determine the relationship between abnormal glucose metabolism and osteoporosis (OP) in Han Chinese men over the age of 50 years. Patients and methods: A cross-sectional study of 775 male patients aged over 50 years was performed at our hospital in 2011. The patients were divided into a normal glucose metabolism group, an impaired glucose regulation (IGR) group, and a type 2 diabetes mellitus (T2DM) group. Differences in their bone mineral densities (BMDs), OP detection rates, and indices of bone metabolism were assessed. Results: After adjusting for age and body mass index (BMI), there were no significant differences in lumbar spine, femoral neck, and total hip BMD values in the three groups ( P . 0.05) nor in OP detection rates ( P = 0.19). However, there were some significant differences in bone metabolism markers between the groups after adjusting for age, BMI, and serum creatinine (Cr): 25-hydroxyvitamin D (25(OH)D) was positively correlated with the presence of abnormal glycometabolism ( r = 0.08; P , 0.01), while β -carboxy-terminal cross-linking telopeptide of type I collagen ( β -CTX), bone gamma-carboxyglutamic acid protein (BGP; osteocalcin [OC]), and procollagen type 1 intact N-terminal propeptide (P1NP) were negatively correlated ( r =- 0.13, - 0.21, - 0.14, respectively; P , 0.01). Logistic regression analysis of the data indicated that BGP was the only bone metabolism marker significantly influenced by abnormal glucose metabolism (OR = 0.96). Conclusion: There were no significant differences in BMD or OP detection rates between the three glycometabolism groups after adjusting for age and BMI. However, the bone metabolism marker, BGP, was significantly negatively correlated with abnormal glucose metabolism.
Binding characterization of N‐(2‐chloro‐5‐thiomethylphenyl)‐ N′‐(3‐[H]3methoxy phenyl)‐N′‐methylguanidine ([H]GMOM), a non‐competitive N‐methyl‐D‐aspartate (NMDA) receptor antagonist

Citation for pulished version (APA): Metaxas, A. , van, B. BNM. , Klein, PJ. , Verbeek, J., Nash, EC. , Kooijman, EJM. , Renjaän, VA. , Golla, SSV. , Boellaard, R. , Christiaans, JAM. , Windhorst, AD. , & Leysen, JE. (2019). Binding characterization of N-(2-chloro5-thiomethylphenyl)-N'-(3-[3 H]3 methoxy phenyl)-N'-methylguanidine ([3 H]GMOM), a non-competitive Nmethyl-D-aspartate (NMDA) receptor antagonist. Pharmacology Research & Perspectives, 7(1), [e00458]. https://doi.org/10.1002/prp2.458
Alcohol Use Among Mexican American and Non-Hispanic White 7th-12th-Grade Students in the Southwestern United States

ABSTRACT This study assessed rates of lifetime and current alcohol use among 7th- through 12th-grade Mexican American and non-Hispanic White students. Students from 55 middle and high schools from the southwestern U.S. completed a survey of alcohol use. Odds ratios were calculated for grade by gender by ethnicity comparisons for Mexican American boys (n = 2570) and girls (n = 3295), and non-Hispanic White boys (n = 1722) and girls (n = 2127). Multiple imputation was used to account for missing data. Consistent with past studies, Mexican American students used alcohol less frequently than non-Hispanic White students, but binge drank more frequently. Somewhat surprisingly, among younger students more girls than boys reported current drinking, but among older students, fewer girls reported recent drunkenness or binge drinking. Grade in school moderated a number of ethnicity and gender differences. Higher rates of alcohol use among young girls compared to young boys may signal increased risk for girls, particularly among Mexican Americans.
Childhood predictors of male criminality: a prospective population-based follow-up study from age 8 to late adolescence.

OBJECTIVE To study childhood predictors for late adolescence criminality. METHOD The follow-up sample included 2,713 Finnish boys born in 1981. Information about the 8-year-old boy' problem behavior was obtained from parents, teachers, and the children themselves. The follow-up information about criminal offenses was based on the national police register between the years 1998 and 2001 when the subjects were 16 to 20 years old. RESULTS According to the national police register, 22.2% of boys had at least one criminal offense other than a minor traffic violation during the 4-year study period. Living in nonintact family, low parental education level, parent reports of conduct problems, and teacher reports of hyperkinetic problems when the child was 8 independently predicted a high level (more than five) of offenses. Living in nonintact family at age 8 predicted all types of criminal offenses. Low parental education level and parent or teacher reports of conduct problems independently predicted violence, property, traffic, and drunk driving offenses. Teacher reports of hyperkinetic problems independently predicted all types of criminal offenses except drunk driving. Self-reports of bullying others independently predicted violent offenses. CONCLUSIONS Living in a broken home, low parental education level, conduct problems, and hyperactivity in middle childhood predict criminal offenses in late adolescence. Efforts to prevent later criminality already in childhood are emphasized.
Self-reported oral health and quality of life in patients with type 2 diabetes mellitus in primary care: a multi-center cross-sectional study

Background: Guidelines for primary diabetes care recommend to pay attention to oral health in patients with diabetes mellitus type 2 (T2DM). However, research about dental care utilization and the extent of problems regarding oral health in these patients is limited. Purpose: To assess self-reported oral health, general health-related quality of life (QoL) and oral health-related QoL in patients with T2DM who regularly attend a family physician office. Methods: Family physician offices were recruited in the area of Amsterdam, the Netherlands, as part of a cluster-randomized controlled trial. At these offices, patients with T2DM were included by family physicians and/or nurse practitioners. Patient data on general characteristics, self-reported oral health (including periodontitis), general health-related QoL (SF-36) and oral health-related QoL (OHIP-NL14) were collected. Results: Twenty-four family physician offices participated, who enrolled 764 patients with T2DM (mean age: 65.9±10.7 years, 56% male, 16% smoker). Almost 11% of the patients were metabolically poorly controlled (HbA1c >63 mmol/mol), 39% were obese (body mass index≥30 kg/m2), 37% had hypertension (systolic blood pressure ≥140 mmHg) and 44% had dyslipidemia (LDL-cholesterol >2.5 mmol/L). About a quarter (24%) reported not to visit a dentist regularly and 30% did not have dental insurance coverage. Furthermore, 16% of the patients were edentulous and having full dental prostheses, while 29% had a partial dental prosthesis. Pain in the mouth, dry mouth and bad breath were reported by 15%, 37% and 12% of the patients, respectively. Almost 70% suffered from periodontitis. Oral health-related QoL was impaired in 19% of the patients, and those subjects also had worse general health-related QoL. Conclusion: Almost a quarter of patients with T2DM at Dutch family physician offices does not visit the dentist regularly. The estimated prevalence of periodontitis is particularly high, but other oral health complaints and impaired oral health-related QoL are also relatively common.
Prevalencia y Factores de Riesgo Asociados a Parasitismo Intestinal en Preescolares de Zona Urbana en Calarcá, Colombia

Objetivo Determinar prevalencia de parasitismo intestinal y su relacion con factores de riesgo sociodemograficos, de saneamiento y practicas de higiene. Materiales y metodos Se realizo un estudio "cross sectional" en 220 ninos entre 6 y 60 meses (N:1 993) asistentes a hogares infantiles de estrato uno y dos del area urbana de Calarca (Colombia). Se estudio una muestra coprologica por metodo de concentracion de Ritchie Resultados La prevalencia general de parasitismo entre los ninos estudiados fue de un 54,7 %. Se encontro una prevalencia de Blastocystis de 36,4 % y de Giardia en 13,2 %. Se encontraron como factores de riesgo asociados estadisticamente con el parasitismo: edad mayor a dos anos, no desparasitar las mascotas, tener hermanos, y recibir alimentos en el tetero diferentes a la leche. Conclusiones Este estudio muestra una alta frecuencia de Blastocystis en ninos preescolares de un centro urbano con buen acceso a servicios publicos. Es necesario hacer enfasis en los programas de control de zoonosis y la desparasitacion de mascotas. Se recomienda la vigilancia periodica de parasitos por examenes en estos ninos.
The prevalence and risk factors associated with ovine lungworm infestation in the Asella province, Central Ethiopia

A cross sectional study design was conducted in Asella province, Central Ethiopia from November 2009 to May 2010. The study was carried out for the purpose of determining the prevalence of lungworm infection in ovine through coproscopic and postmortem examination in the Asella province. Moreover, the study assesses the association of some bionomic factors on the different risk factors and the correlation between adult worm burden and fecal larval output during the study time. Faecal samples (381) were collected from sheep of different age groups, husbandry system and health care, of both sexes; and additionally from 71 sheep slaughtered at Asella town restaurant and hotels, with both intact lung and fecal samples were randomly selected. The investigation also consists of questionnaire survey. Out of 381 fecal samples coproscopically examined, 276 (72.44%) were found to be infected with one or more species of lungworm. Sheep showing respiratory clinical signs, non-dewormed with anthelmintics and raised in extensive husbandry system when compared with those sheep that apparently appeared healthy, dewormed ones and of semi-intensive husbandry system shows statistically significant variation (P 0.05). The postmortem examination carried out on 71 sheep revealed that coproscopic examination had limited value in terms of estimating the prevalence of lungworm infection in live sheep and implies as there was no direct correlation between the adult worm burden and faecal larval output. The prevalence of lungworm infection observed through postmortem coproscopic examination and postmortem intact lung incision was 39.4 and 26.8%, respectively. Key words: Asella province, Central Ethiopia, lungworm, ovine, prevalence, risk factors.
NUCLEOSIDES, NUCLEOTIDES & NUCLEIC ACIDS

A possibility of site-directed chemical modification of a ssDNA fragment with ‘‘trioligonucleotide reagent’’ (TOR), consisting of a central oligonucleotide derivative carrying N-(2-chloroethyl)-N-(p-formylphenyl)-N-propyl-N-3-ydeneamino groups at both 5’and 3’-thiophosphate ends and two border derivatives with 4-carbohydrazidephenyl groups at their 3’and 5’-phosphate ends, respectively, is shown. Products of site-directed fragment cleavage, more abundant than the alkylation products, were found at 50 C. The overall level of DNA modification by TOR reached 30% at a small excess of the oligonucleotide derivatives.
Cultural heritage authenticity: Effects on place attachment and revisit intention through the mediating role of tourist experience

Authenticity is a central aspect and prominent feature of heritage tourism. Both practitioners and researchers are interested in the authenticity of tourism experiences when it comes to heritage tourism planning, marketing and management. The paper aims to explore the intervening role of tourist experience in the link between cultural heritage authenticity and place attachment and revisit intention, in the context of Egyptian cultural heritage sites. An integrative model was developed to explore the importance of cultural heritage authenticity and its influence on place attachment and revisit intention, through the mediating role of tourist experience. Using Smart PLS 4, data collected from 389 international tourists who visited Egypt were analysed. The findings of the study highlighted that tourist experience fully mediates the relationship between cultural heritage authenticity and both place attachment and revisit intention. The results also identified the positive direct effect of cultural heritage authenticity on tourist experience. The positive direct effects of tourist experience on place attachment and revisit intention were also significant. Findings hold important implications for both the research community and destination management and marketing organizations and heritage sites. Practical implications and potential future research are also discussed.