Miracle-dz/UniFAR-FTUs huggingface dataset:
ICT Competence, Organizational Culture, Motivation, and Task Performance among the Employees of One Polytechnic University Branch

This study identified the ICT Competence, Organizational Culture, Motivation, and Task Performance among the Employees of Polytechnic University of the Philippines-Ragay, Camarines Sur Branch. Descriptive-survey was conducted for the 38 employees of the said university branch for the Second Semester of Academic Year 2019-2020. It was revealed that The employees’ competence in using ICT resources in a higher education institution is within Skillful to Much Skillful levels. It Often Observed the different components of Organizational Culture as they are Often Motivated and Often performed in their organization. Considering that the ICT competence of the employees is affected by the availability of the ICT resources in the institution and their exposure to the ICT resources. It is also recommended for the higher authority of the university and the Commission on Higher Education to prioritize the procurement of relevant resources, equipment, and facilities related to ICT integration in Higher Education Institutions, and training and skills empowerment of staff of the organization should be regularly conducted.
Effect of Controlled Day and Night Temperatures on Grape Coloration

Fruit coloration was investigated in several cultivars of Vitis vinifera L. grown in pots in sunlit phototron rooms held at various day and night temperatures. Mature 9Cardinal9, 9Pinot noir9, and 9Tokay9 fruits ripened at cool-day (15°C) and cool-night (15°C) temperatures had much greater coloration than fruits ripened at hot-day (35°C) and cool-night (15°C), hot-day (35°C) and warm-night (25°C), or cool-day (15°C) and warm-night (25°C) temperatures. Fruits grown at cool-day warm-night temperatures, however, had significantly greater levels of anthocyanins than fruits ripened at hot day temperatures, regardless of the night temperature. On the other hand, 9Cardinal9 and 9Pinot noir9 berries grown at hot-day (35°C) and warm-night (25 or 30°C) had a higher level of anthocyanins than fruit ripened at hot-day cool-night (15 or 10°C). A day temperature of 35°C completely inhibited anthocyanin synthesis in 9Tokay9 berries, regardless of night temperature. Also, a 30°C night temperature (day temperature 25°C) prevented anthocyanin formation in 9Tokay9 and greatly reduced the coloration of 9Cabernet Sauvignon9 compared with fruits ripened at 15 and 20°C night temperatures. On the basis of fruit coloration, 9Tokay9 was least tolerant to hot temperature, and 9Pinot noir, and 9Cabernet Sauvignon9 were most tolerant.
Exploring the Teacher’s Utilization of ICT Resources in Schools and their Student’s Competence in Basic Computer Applications

This descriptive study explored the Teacher’s Utilization of ICT Resources in Schools and their Student’s Competence in Basic Computer Applications. This involved the fourteen Science teachers and the 245 Grade 10 students in the three selected public secondary schools in Ragay, Camarines Sur, Philippines, for the School Year 2019-2020. It revealed that selected public secondary schools in Ragay Sometimes Utilized various ICT Resources in teaching Science, and the Science teachers of those schools are Skillful in Information and Communications Technology and are Much Ready in Equipment Readiness in integrating ICT in school and at home; their Grade 10 students are Competent in the Basic Computer Applications particularly in the Word Processing, Spreadsheet application, PowerPoint Presentation and the Use of Internet. Thus, it is recommended that computers and the internet be made available for students and teachers and regular training of teachers to utilize various resources in teaching Science to improve the students’ critical thinking, motivation, and higher-order thinking skills.
Noise in Expectations: Evidence from Analyst Forecasts

Analyst forecasts outperform econometric forecasts in the short run but underperform in the long run. We decompose these differences in forecasting accuracy into analysts’ information advantage, forecast bias, and forecast noise. We find that noise and bias strongly increase with forecast horizon, while analysts’ information advantage decays rapidly. A noise increase with horizon generates a mechanical reversal in the sign of the error-revision (Coibion-Gorodnichenko) regression coefficient at longer horizons, independently of over-/underreaction. A parsimonious model with bounded rationality and a noisy cognitive default matches the term structures of noise and bias jointly.
Income and Balance Sheet Diversification Effects on Banks’ Cost and Profit Efficiency: Evidence from the US

Using two-stage instrumental variable technique and two-step system GMM approach, we provide empirical evidence on impact of income, asset, and funding diversifications on the cost and profit efficiency of the US commercial banks over the period from 2002 to 2019. Our results show that funding and income (assets) diversification has a positive (detrimental) effect on the cost efficiency of the banks, while funding (income) diversification has a significantly negative (positive) effect on profit efficiency. Our findings reveal that during the global financial crisis asset diversification is not beneficial for the banks, whereas funding ‎diversification has a positive effect on cost and profit efficiency. ‎ Our results confirm bi-directional causality between cost and profit efficiency in commercial banks of the US. Out mixed results of the influence of income, asset, and funding diversifications on the cost and profit efficiency of the banks with varying characteristics have useful implications for policymakers and regulators‎.
Double-Edged Sword of Female Political Leadership: Gender Diversity–Inducing and Gender Diversity–Reducing Effects in the Workplace

This study examines how the election of a top female political leader affects the representation of women within organizations. We argue that the election of a top female political leader has two countervailing effects. On the one hand, having a top female political leader can increase the representation of women in higher-level positions in organizations, leading to a gender diversity–inducing effect. On the other hand, it can also generate a disproportionate outflow of women from wage employment into entrepreneurship, leading to a gender diversity–reducing effect. Finally, the strength of the two effects will depend on female employee’s qualification signals. Using an exogenous presidential election result from South Korea, we find broad support for our theory and hypotheses.
Financing Sustainable Entrepreneurship: ESG Measurement, Valuation, and Performance in Token Offerings

Sustainable Entrepreneurship (SE) seeks to attain profitability and sustainability goals. A major research gap concerns SE’s economic attractiveness for entrepreneurs and investors. The question is ambiguous because sustainability orientation creates costly constraints, while startups cannot fully appropriate their positive externalities. We relate startups’ Environment, Society, and Governance (ESG) properties obtained from a machine-learning approach (www.SustainableEntrepreneurship.org) to SE valuation and performance in token offerings. Startups with salient ESG goals are able to raise financing at more favorable valuations, incentivizing entrepreneurs to adopt ESG goals in the first place. However, their post-funding performance is weaker than in conventional startups, suggesting that investors incur a relative financial loss for backing sustainability-oriented entrepreneurs. Both valuation and post-funding performance are weaker in ESG startups with pre-existing binding constraints.
Arrow-Debreu Meets Kyle

We consider an extension of the Kyle (1985) model where Arrow-Debreu securities are traded and the informed trader has private information regarding arbitrary higher moments of the asset payoff distribution. In this setting, we analyze price discovery and informed demand of Arrow-Debreu securities---equivalently, options. The informed trader strategy in our model is consistent with options trading strategies used to trade on higher moments in practice. The probability law of market maker's posterior is independent of specification of asset payoffs. The information efficiency of Arrow-Debreu prices decreases with respect to the dispersion of the informed trader's private signal.
Necrotizing Soft Tissue Infection: A Single-Center Retrospective Study of Treatment and Outcomes

Introduction Necrotizing fasciitis is a severe inflammatory disease of the body's soft tissue characterized by spreading rapidly and high mortality. Rapid surgical intervention along with other supportive measures of treatment have a great impact on the outcome of treatment. Material and methods This study was conducted by a retrospective medical record review of all patients with a microbiologically and clinically confirmed diagnosis of necrotizing fasciitis who were admitted to the general surgery department at the General Hospital Novi Pazar, Serbia, during the period between 2017 and 2020. Demographic, clinical, laboratory, and microbiology data were analyzed. Results A total of 13 cases were identified, which represents 0.21% of the total number of patients treated at the surgical department during the period January 2017 to November 2020. The mean age of patients was 55 years, with a male/female ratio of 1:1.6. All of them had at least one comorbidity and more than half had three or more. Diabetes, cardiovascular diseases, and obesity were the most common comorbidities. The most common causes of infection were Klebsiella spp, Pseudomonas aeruginosa, S. pyogenes, and S. aureus. All patients received multiple surgical interventions (mean 2.3). Conclusion Treating necrotizing fasciitis requires a multidisciplinary approach. Early diagnosis and rapid clinical response allow for better disease outcomes. Getting to know more about necrotizing fasciitis will help doctors make better decisions when treating it.
Induction of Neurogenesis and Angiogenesis in a Rat Hemisection Spinal Cord Injury Model With Combined Neural Stem Cell, Endothelial Progenitor Cell, and Biomimetic Hydrogel Matrix Therapy

Supplemental Digital Content is available in the text. OBJECTIVES: Acute spinal cord injury is a devastating injury that may lead to loss of independent function. Stem-cell therapies have shown promise; however, a clinically efficacious stem-cell therapy has yet to be developed. Functionally, endothelial progenitor cells induce angiogenesis, and neural stem cells induce neurogenesis. In this study, we explored using a multimodal therapy combining endothelial progenitor cells with neural stem cells encapsulated in a bioactive biomimetic hydrogel matrix to facilitate stem cell–induced neurogenesis and angiogenesis in a rat hemisection spinal cord injury model. DESIGN: Laboratory experimentation. SETTING: University laboratory. SUBJECTS: Female Fischer 344 rats. INTERVENTIONS: Three groups of rats: 1) control, 2) biomimetic hydrogel therapy, and 3) combined neural stem cell, endothelial progenitor cell, biomimetic hydrogel therapy underwent right-sided spinal cord hemisection at T9–T10. The blinded Basso, Beattie, and Bresnahan motor score was obtained weekly; after 4 weeks, observational histologic analysis of the injured spinal cords was completed. MEASUREMENTS AND MAIN RESULTS: Blinded Basso, Beattie, and Bresnahan motor score of the hind limb revealed significantly improved motor function in rats treated with combined neural stem cell, endothelial progenitor cell, and biomimetic hydrogel therapy (p < 0.05) compared with the control group. The acellular biomimetic hydrogel group did not demonstrate a significant improvement in motor function compared with the control group. Immunohistochemistry evaluation of the injured spinal cords demonstrated de novo neurogenesis and angiogenesis in the combined neural stem cell, endothelial progenitor cell, and biomimetic hydrogel therapy group, whereas, in the control group, a gap or scar was found in the injured spinal cord. CONCLUSIONS: This study demonstrates proof of concept that multimodal therapy with endothelial progenitor cells and neural stem cells combined with a bioactive biomimetic hydrogel can be used to induce de novo CNS tissue in an injured rat spinal cord.
MicroRNA profiles in five pairs of early gastric cancer tissues and adjacent non-cancerous tissues

Approximately half of the world's gastric cancer cases and deaths occur in China. In addition, the incidence and mortality rates of gastric cancer in Gansu province in China are much higher than the average nationwide levels. The present study investigated microRNA (miRNA/miR) profiles in early gastric cancer (EGC) without specific symptoms. miRNA expression levels in five pairs of EGC tissues and adjacent non-cancerous mucosa tissues of patients from Gansu province in China were analyzed using a miRNA microarray. A total of 47 differentially expressed miRNAs (DEMs) were identified. Subsequently, mRNA expression profiles of three pairs of cancer tissues and adjacent non-cancerous tissues from 3 Asian patients with stage I or stage II gastric cancer (stage I/II; American Joint Committee on Cancer classification, Eighth Edition) were obtained from The Cancer Genome Atlas database, and differentially expressed genes (DEGs) were identified. The target genes of DEMs were filtered from the DEGs using the miRDB database and a miRNA-gene network was constructed. The functions of DEMs were evaluated using the tool for annotations of human miRNAs database, and via Gene Ontology analysis, Kyoto Encyclopedia of Genes and Genomes analysis and Gene Set Enrichment Analysis of the target genes. Finally, survival analyses of DEMs, which were in the miRNA-gene network, was performed. The results suggested that a number of miRNAs, including hsa-let-7a-5p, hsa-miR-27a-3p, hsa-miR-126-5p and hsa-miR-424-5p, may serve critical roles in EGC. The present study could provide a basis for the identification of EGC screening biomarkers. Furthermore, the present study may provide a basis for the exploration of the cause of the high incidence of gastric cancer in Gansu province from the perspective of miRNAs.
North Atlantic deep water and Antarctic bottom water: their interaction and influence on modes of the global ocean circulation = Die wechselseitige Beeinflussung von nordatlantischem Tiefenwasser und antarktischem Bodenwasser und ihre Rolle für globale Moden der ozeanischen Zirkulation

Interhemispheric signal transmission in the Atlantic Ocean connects the deep water production regions of both hemispheres. The nature of these interactions and large scale responses to perturbations on time scales of years to millenia have been investigated using a global three-dimensional general circulation model based on the primitive equations (GFDL’s MOM-2) coupled to a dynamic-thermodynamic sea ice model with a viscous-plastic rheology. The coupled model reproduces many aspects of today’s oceanic circulation. Testing the model’s sensitivity with regard to changes in the model configuration and parameterizations revealed a strong dependence of the model results from eddy diffusivities, filtering and topographic effects. Restoring time scales for surface salinity were found to be of minor importance. The internal variability in the ocean-sea ice system has been addressed by analyzing the model results with statistical techniques. A decadal oscillation could be identified in the Southern Ocean. A sequence of Kelvin and Rossby waves carries anomalies in this frequency band northward across the equator. Longer-term variability in the ocean is mainly determined by advective processes. A set of experiments in which the surface boundary conditions were changed showed the necessity to continue integrations over thousands of years until new equilibria are established. Buoyancy changes in the Weddell and Labrador Seas exert a direct effect on the overturning cells of the respective hemisphere. They influence the density structure of the deep ocean and thereby lead to alterations in the strength of the ACC. The model results suggest an influence of the ACC on convective activities in the Southern Ocean. Changing the wind stress south of 30°S influences the magnitude of the deep water production of both hemispheres. The interhemispheric effect in these experiments cannot be explained solely by advective mechanisms (contradicting previous studies by TOGGWEILER AND SAMUELS, 1993a, 1995). Switching off the wind stress over the latitude band of the Drake Passage leads to a slow gradual decrease of the water mass transport in the ACC resulting in an almost complete cessation.
Whole-body diffusion-weighted magnetic resonance imaging and apparent diffusion coefficient values as prognostic factors in multiple myeloma

Multiple myeloma (MM) is a neoplasm of the B lymphocytes characterized by the uncontrolled proliferation of a plasmocyte clone. Magnetic resonance imaging (MRI) remains the most sensitive and specific imaging method for the detection of bone marrow infiltration, before macroscopic bone changes are visible, with evidence that the detection rate and overall performance of MRI could be enhanced by applying diffusion-weighted imaging (DWI). The aim of our research was to evaluate whether measuring apparent diffusion coefficient (ADC) values in newly diagnosed patients with MM could be a prognostic factor for the course of the disease and to ascertain whether there is any correlation with other prognostic factors in MM. A retrospective study was performed on a group of 32 patients with newly diagnosed MM that underwent at least two whole-body (WB)-MRIs; one before and one after induction therapy. Patients with advanced stage of disease showed an increased ADC value: Stage 2 vs. stage 1 (1.162 vs. 0.289, P=0.033), respectively, stage 3 vs. stage 1 (0.867 vs. 0.289, P=0.041). In addition, ADC values were inversely correlated with survival time: r=-0.641, P<0.001. According to the multivariate linear regression model, we observed that for every point of ADC value (before treatment) the survival was decreased/reduced by 14.5 months. Moreover, bortezomib therapy predicted an increase in the survival length/duration by 7.9 months. Our regression equation proved to be a good fit for the model, explaining 57.8% of survival duration (adjusted R2=0.578). In conclusion, the negative prognostic factors associated with WB-MRI are represented by high ADC values before treatment (for every point of ADC the survival was decreased by 14.5 months) and focal/diffuse marrow involvement.
Histomorphology of Amyotrophic Lateral Sclerosis: An Autopsy Case Report

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease affecting predominantly the motor neurons of the anterior horns of the spinal cord. The condition, in most cases, starts with lower limb muscle weakness that steadily progresses and affects all muscle groups of the body. This in time leads to severe muscle atrophy and muscle paralysis, with respiratory muscle affection leading to respiratory failure. Several clinical investigations such as a physical examination, imaging modalities of the spinal cord, electroencephalography, electromyography, and genetic tests in the case of suspicion of a hereditary form are often informative enough to place the diagnosis. Histological changes are often nonspecific with neuronal degeneration and demyelination in the anterior horns of the spinal cord being the most severe changes. Here, we present the classical constellation of histopathological changes associated with ALS along with demyelination, neuronal degeneration, Lewy-like intra and extracellular bodies, and intracellular Bunina bodies.
Next-generation sequencing-based identification of EGFR and NOTCH2 complementary mutations in non-small cell lung cancer

Although targeted therapy has emerged as an effective treatment strategy for non-small cell lung cancer (NSCLC), some patients cannot benefit from such therapy due to the limited number of therapeutic targets. The present study aimed to identify mutated genes associated with clinicopathological characteristics and prognosis and to screen for mutations that are not concurrent with applicable drug target sites in patients with NSCLC. Tumor tissue and blood samples were obtained from 97 patients with NSCLC. A lung cancer-specific panel of 55 genes was established and analyzed using next-generation sequencing (NGS). The results obtained from the clinical cohort were compared with the NSCLC dataset from The Cancer Genome Atlas (TCGA). Subsequently, 25 driver genes were identified by taking the intersection of the 55 lung-cancer-specific genes with three databases, namely, the Catalog of Somatic Mutations in Cancer database, the Network of Cancer Genes database and Vogelstein's list. Functional annotation and protein-protein interaction analysis were conducted on these 25 driver genes. The χ2 test and logistic regression were used to evaluate the association between mutations in the 25 driver genes and the clinicopathological characteristics of 97 patients, and phosphatase and tensin homolog (PTEN) and kirsten rat sarcoma viral oncogene homolog (KRAS) were associated with stage at diagnosis and sex, respectively, while epidermal growth factor receptor (EGFR) was associated with sex, stage at diagnosis, metastasis, CEA and CYFRA21-1. Moreover, the association between the 25 driver gene mutations and overall survival were examined using Cox regression analysis. Age and Notch homolog 2 (NOTCH2) mutations were independent prognostic factors in TCGA dataset. The correlations between statistically significant mutations in EGFR, KRAS, PTEN and NOTCH2 were further examined, both in the clinical data and TCGA dataset. There was a negative correlation between EGFR and NOTCH2 mutations (correlation coefficient, −0.078; P=0.027). Thus, the present study highlights the importance of NOTCH2 mutations and might provide novel therapeutic options for patients with NSCLC who do not harbor EGFR mutations.
Mesoporous Biopolymer Architecture Enhanced the Adsorption and Selectivity of Aqueous Heavy-Metal Ions

Halloysite nanotubes (HNT) and ball-milled biochar (BC) incorporated biocompatible mesoporous adsorbents (HNT-BC@Alg) were synthesized for adsorption of aqueous heavy-metal ions. HNT-BC@Alg outperformed the BC, HNT, and BC@Alg in removing cadmium (Cd), copper (Cu), nickel (Ni), and lead (Pb). Mesoporous structure (∼7.19 to 7.56 nm) of HNT-BC@Alg was developed containing an abundance of functional groups induced from encapsulated BC and tubular HNT, which allowed heavy metals to infiltrate and interact with the adsorbents. Siloxane groups from HNT, oxygen-containing functional groups from BC, and hydroxyl and carboxyl groups from alginate polymer play a significant role in the adsorption of heavy-metal ions. The removal percentage of heavy metals was recorded as Pb (∼99.97 to 99.05%) > Cu (∼95.01 to 90.53%) > Cd (∼92.5 to 55.25%) > Ni (∼80.85 to 50.6%), even in the presence of 0.01/0.001 M of CaCl2 and Na2SO4 as background electrolytes and charged organic molecule under an environmentally relevant concentration (200 μg/L). The maximum adsorption capacities of Ni, Cd, Cu, and Pb were calculated as 2.85 ± 0.08, 6.96 ± 0.31, 16.87 ± 1.50, and 26.49 ± 2.04 mg/g, respectively. HNT-BC@Alg has fast sorption kinetics and maximum adsorption capacity within a short contact time (∼2 h). Energy-dispersive X-ray spectroscopy (EDS) elemental mapping exhibited that adsorbed heavy metals co-distributed with Ca, Si, and Al. The reduction of surface area, pore volume, and pore area of HNT-BC@Alg (after sorption of heavy metals) confirms that mesoporous surface (2–18 nm) supports diffusion, infiltration, and interaction. However, a lower range of mesoporous diameter of the adsorbent is more suitable for the adsorption of heavy-metal ions. The adsorption isotherm and kinetics fitted well with the Langmuir isotherm and the pseudo-second-order kinetic models, demonstrating the monolayer formation of heavy-metal ions through both the physical sorption and chemical sorption, including pore filling, ion exchange, and electrostatic interaction.