Miracle-dz/UniFAR-FTUs huggingface dataset:
High SARS-CoV-2 Seroprevalence among Healthcare Workers in Bamako, Mali

In Mali, a country in West Africa, cumulative confirmed COVID-19 cases and deaths among healthcare workers (HCWs) remain enigmatically low, despite a series of waves, circulation of SARS-CoV-2 variants, the country’s weak healthcare system, and a general lack of adherence to public health mitigation measures. The goal of the study was to determine whether exposure is important by assessing the seroprevalence of anti-SARS-CoV-2 IgG antibodies in HCWs. The study was conducted between November 2020 and June 2021. HCWs in the major hospitals where COVID-19 cases were being cared for in the capital city, Bamako, Mali, were recruited. During the study period, vaccinations were not yet available. The ELISA of the IgG against the spike protein was optimized and quantitatively measured. A total of 240 HCWs were enrolled in the study, of which seropositivity was observed in 147 cases (61.8%). A continuous increase in the seropositivity was observed, over time, during the study period, from 50% at the beginning to 70% at the end of the study. HCWs who provided direct care to COVID-19 patients and were potentially highly exposed did not have the highest seropositivity rate. Vulnerable HCWs with comorbidities such as obesity, diabetes, and asthma had even higher seropositivity rates at 77.8%, 75.0%, and 66.7%, respectively. Overall, HCWs had high SARS-CoV-2 seroprevalence, likely reflecting a “herd” immunity level, which could be protective at some degrees. These data suggest that the low number of cases and deaths among HCWs in Mali is not due to a lack of occupational exposure to the virus but rather related to other factors that need to be investigated.
An integrative taxonomic revision of slug-eating snakes (Squamata: Pareidae: Pareineae) reveals unprecedented diversity in Indochina

Slug-eating snakes of the subfamily Pareinae are an insufficiently studied group of snakes specialized in feeding on terrestrial mollusks. Currently Pareinae encompass three genera with 34 species distributed across the Oriental biogeographic region. Despite the recent significant progress in understanding of Pareinae diversity, the subfamily remains taxonomically challenging. Here we present an updated phylogeny of the subfamily with a comprehensive taxon sampling including 30 currently recognized Pareinae species and several previously unknown candidate species and lineages. Phylogenetic analyses of mtDNA and nuDNA data supported the monophyly of the three genera Asthenodipsas, Aplopeltura, and Pareas. Within both Asthenodipsas and Pareas our analyses recovered deep differentiation with each genus being represented by two morphologically diagnosable clades, which we treat as subgenera. We further apply an integrative taxonomic approach, including analyses of molecular and morphological data, along with examination of available type materials, to address the longstanding taxonomic questions of the subgenus Pareas, and reveal the high level of hidden diversity of these snakes in Indochina. We restrict the distribution of P. carinatus to southern Southeast Asia, and recognize two subspecies within it, including one new subspecies proposed for the populations from Thailand and Myanmar. We further revalidate P. berdmorei, synonymize P. menglaensis with P. berdmorei, and recognize three subspecies within this taxon, including the new subspecies erected for the populations from Laos and Vietnam. Furthermore, we describe two new species of Pareas from Vietnam: one belonging to the P. carinatus group from southern Vietnam, and a new member of the P. nuchalis group from the central Vietnam. We provide new data on P. temporalis, and report on a significant range extension for P. nuchalis. Our phylogeny, along with molecular clock and ancestral area analyses, reveal a complex diversification pattern of Pareinae involving a high degree of sympatry of widespread and endemic species. Our analyses support the “upstream” colonization hypothesis and, thus, the Pareinae appears to have originated in Sundaland during the middle Eocene and then colonized mainland Asia in early Oligocene. Sundaland and Eastern Indochina appear to have played the key roles as the centers of Pareinae diversification. Our results reveal that both vicariance and dispersal are responsible for current distribution patterns of Pareinae, with tectonic movements, orogeny and paleoclimatic shifts being the probable drivers of diversification. Our study brings the total number of Pareidae species to 41 and further highlights the importance of comprehensive taxonomic revisions not only for the better understanding of biodiversity and its evolution, but also for the elaboration of adequate conservation actions.
Dynamic response of underreamed batter piles subjected to vertical vibration

ABSTRACT This paper presents the dynamic vertical response of a vertical and two batter piles with an underreamed bulb. Batter angles (i.e. inclination to the vertical) of 10 and 20 degrees have been considered. The dynamic vertical tests were conducted using a mechanical oscillator-motor assembly by varying the intensity of exciting force level with a change in eccentricity setting of the oscillator. The dynamic response was recorded in terms of operating frequency and acceleration response. The test data were analysed to estimate the dynamic vertical responses of the piles in terms of resonant frequency, f y ꞌ; peak vertical displacement amplitude, dyꞌ and axial strain εy , and they were compared. For all three piles, with an increase in intensity of exciting force level, the resonant frequency decreased, whereas the peak vertical displacement and axial strain increased.
Relationship Between Vitamin D and Thyroid: An Enigma

Hypothyroidism is a frequently encountered endocrine disorder in clinical practice. Besides its traditional role in bone health, vitamin D has been shown to have favorable effects in a variety of different systems due to its pleiotropic qualities and ubiquitous receptor expression. Over the years, researchers have been fascinated by the intricate molecular interplay between vitamin D and thyroid. In this regard, attempts have emerged to demonstrate the role of vitamin D in thyroid disorders. This article has reviewed the existing literature on the role of vitamin D in hypothyroidism. We explored studies discussing the physiological interactions between vitamin D and thyroid, as well as the clinical consequences, supplemental and prognostic relevancy of vitamin D in auto-immune thyroid disease (AITD) and hypothyroidism.
Non-invasive vagus nerve stimulation for prevention of migraine: The multicenter, randomized, double-blind, sham-controlled PREMIUM II trial

Aim Evaluate the efficacy and safety of non-invasive vagus nerve stimulation for migraine prevention. Methods After completing a 4-week diary run-in period, adults who had migraine with or without aura were randomly assigned to receive active non-invasive vagus nerve stimulation or sham therapy during a 12-week double-blind period. Results Of 336 enrolled participants, 113 (active, n = 56; sham, n = 57) completed ≥70 days of the double-blind period and were ≥66% adherent with treatment, comprising the prespecified modified intention-to-treat population. The COVID-19 pandemic led to early trial termination, and the population was ∼60% smaller than the statistical target for full power. Mean reduction in monthly migraine days (primary endpoint) was 3.12 for the active group and 2.29 days for the sham group (difference, −0.83; p = 0.2329). Responder rate (i.e. the percentage of participants with a ≥50% reduction in migraine days) was greater in the active group (44.87%) than the sham group (26.81%; p = 0.0481). Prespecified subgroup analysis suggested that participants with aura responded preferentially. No serious device-related adverse events were reported. Conclusions These results suggest clinical utility of non-invasive vagus nerve stimulation for migraine prevention, particularly for patients who have migraine with aura, and reinforce the well-established safety and tolerability profile of this therapy. Trial Registration: ClinicalTrials.gov (NCT03716505).
Validation of the Trauma and Injury Severity Score for Prediction of Mortality in a Greek Trauma Population

Supplemental Digital Content is Available in the Text. BACKGROUND: Although the Trauma and Injury Severity Score (TRISS) has been extensively used for mortality risk adjustment in trauma, its applicability in contemporary trauma populations is increasingly questioned. OBJECTIVE: The study aimed to evaluate the predictive performance of the TRISS in its original and revised version and compare these with a recalibrated version, including current data from a Greek trauma population. METHODS: This is a retrospective cohort study of admitted trauma patients conducted in two tertiary Greek hospitals from January 2016 to December 2018. The model algorithm was calculated based on the Major Trauma Outcome Study coefficients (TRISSMTOS), the National Trauma Data Bank coefficients (TRISSNTDB), and reweighted coefficients of logistic regression obtained from a Greek trauma dataset (TRISSGrTD). The primary endpoint was inhospital mortality. Models' prediction was performed using discrimination and calibration statistics. RESULTS: A total of 8,988 trauma patients were included, of whom 854 died (9.5%). The TRISSMTOS displayed excellent discrimination with an area under the curve (AUC) of 0.912 (95% CI 0.902–0.923) and comparable with TRISSNTDB (AUC = 0.908, 95% CI 0.897–0.919, p = .1195). Calibration of both models was poor (Hosmer–Lemeshow test p < .001), tending to underestimate the probability of mortality across almost all risk groups. The TRISSGrTD resulted in statistically significant improvement in discrimination (AUC = 0.927, 95% CI 0.918–0.936, p < .0001) and acceptable calibration (Hosmer–Lemeshow test p = .113). CONCLUSION: In this cohort of Greek trauma patients, the performance of the original TRISS was suboptimal, and there was no evidence that it has benefited from its latest revision. By contrast, a strong case exists for supporting a locally recalibrated version to render the TRISS applicable for mortality prediction and performance benchmarking.
Petrogenesis, W metallogenic and tectonic implications of granitic intrusions in the southern Great Xing’an Range W belt, NE China: insights from the Narenwula Complex

Abstract Extensive magmatism in NE China, eastern Central Asian Orogenic Belt, has produced multi-stage granitic plutons and accompanying W mineralization. The Narenwula complex in the southwestern Great Xing’an Range provides important insights into the petrogenesis, geodynamic processes and relationship with W mineralization. The complex comprises granodiorites, monzogranites and granite porphyry. Mafic microgranular enclaves are common in the granodiorites, and have similar zircon U–Pb ages as their host rocks (258.5–253.9 Ma), whereas the W-bearing granitoids yield emplacement ages of 149.8–148.1 Ma. Permian granodiorites are I-type granites that are enriched in large-ion lithophile elements and light rare earth elements, and depleted in high field strength elements and heavy rare earth elements. Both the mafic microgranular enclaves and granodiorites have nearly identical zircon Hf isotopic compositions. The results suggest that the mafic microgranular enclaves and granodiorites formed by the mixing of mafic and felsic magmas. W-bearing granitoids are highly fractionated A-type granites, enriched in Rb, Th, U and Pb, and depleted in Ba, Sr, P, Ti and Eu. They have higher W concentrations and Rb/Sr ratios, and lower Nb/Ta, Zr/Hf and K/Rb ratios than the W-barren granodiorites. These data and negative ϵHf(t) values (–6.0 to –2.1) suggest that they were derived from the partial melting of ancient lower crust and subsequently underwent extreme fractional crystallization. Based on the regional geology, we propose that the granodiorites were generated in a volcanic arc setting related to the subduction of the Palaeo-Asian Ocean, whereas the W-bearing granitoids and associated deposits formed in a post-orogenic extensional setting controlled by the Mongol–Okhotsk Ocean and Palaeo-Pacific Ocean tectonic regimes.
Cosmoparticle Physics of Dark Universe

The physics of the dark Universe goes beyond the standard model (BSM) of fundamental interactions. The now-standard cosmology involves inflation, baryosynthesis and dark matter/energy corresponding to BSM physics. Cosmoparticle physics offers cross disciplinary study of the fundamental relationship of cosmology and particle physics in the combination of its physical, astrophysical and cosmological signatures. Methods of cosmoparticle physics in studies of BSM physics in its relationship with inevitably nonstandard features of dark universe cosmology are discussed. In the context of these methods, such exotic phenomena as primordial black holes, antimatter stars in baryon asymmetrical Universe or multi-charged constituents of nuclear interacting atoms of composite dark matter play the role of sensitive probes for BSM models and their parameters.
Reducing Tillage Affects Long-Term Yields but Not Grain Quality of Maize, Soybeans, Oats, and Wheat Produced in Three Contrasting Farming Systems

Reducing tillage has been widely promoted to reduce soil erosion, maintain soil health, and sustain long-term food production. The effects of reducing tillage on crop nutritional quality in organic and conventional systems, however, has not been widely explored. One possible driver of crop nutritional quality might be the changing soil nitrogen (N) availability associated with reduced tillage in various management systems. To test how reducing tillage affects crop nutritional quality under contrasting conventional and organic farming systems with varied N inputs, we measured nutritional quality (protein, fat, starch, ash, net energy, total digestible nutrients, and concentrations of Ca, K, Mg, P, and S) of maize, wheat, oats, and soybeans harvested from a long-term trial comprised of three farming systems under two tillage regimes: a conventional grain system (CNV); a low-input organic grain system (LEG); and an organic, manure-based grain + forage system (MNR) under conventional full-tillage (FT) and reduced-till (RT) management. Although maize and wheat yields were 10–13% lower under RT management, grain quality metrics including protein, fat, starch, energy, and mineral concentrations were not significantly affected by reducing tillage. Differences in nutrient quality were more marked between farming systems: protein levels in maize were highest in the MNR system (8.1%); protein levels in soybeans were highest in the LEG system (40.4%); levels of protein (12.9%), ash (2.0%), and sulfur (1430 ppm) in wheat were highest in the CNV system, and oat quality was largely consistent between the LEG and MNR systems. As grain quality did not significantly respond to reducing tillage, other management decisions that affect nutrient availability appear to have a greater effect on nutrient quality.
Altitudinal Variation in Soil physico-chemical properties of a Western Himalayan
Forest , Uttarakhand, India

The physico-chemical properties of soil vary with the variation in the topographic features, climatic conditions and forest types. In any forest ecosystem, both vegetation and soil influence each other through nutrient cycles. The altitudinal variation in soil physico-chemical properties was analyzed in a temperate forest (Radi forest) of Upper Yamuna Forest Division in Uttarkashi district of Uttarakhand (Western Himalaya, India). A total of three forest sites were selected at different altitudes (the lower, middle, and upper) to collect composite soil samples from each site covering 0–10 cm, 11–20 cm and 21–30 cm depths. The textural class of the soils was sandy loam. The colour of the soil samples varied from brown to very dark brown. The water holding capacity (r = 0.994), soil organic carbon (r = 0.967), organic matter (r = 0.966), nitrogen (r = 0.993), phosphorus (r = 0.982) and potassium content (r = 0.994) had positive correlation with altitude whereas negative correlation was observed between altitude and soil pH (r = -0.983) in the study. The present study concludes that soil physico-chemical properties in temperate forests of Uttarakhand Himalaya vary significantly with variation in altitude.
The Determinants of Agricultural Crop Productivity among Smallholder Households in Haramaya Distinct, Eastern Ethiopia

The agricultural crop is a backbone in Ethiopia since the country's economy is mainly dependent on agriculture, which is dominated by subsistence smallholder farmers who are partially integrated into the market. The objective of this study was to identify the determinants of crop productivity among smallholder farmers in Haramaya distinct, Eastern Ethiopia. A two-stage random sampling procedure was employed to detect a sample containing 260 smallholder households in the study area. Data was collected through semi-structured questionnaire schedules administered to the selected household farmers. The features of smallholder farmers were analyzed through descriptive statistics and multiple linear regression models. The results indicated that the length of farming experience of the household head, number of economically active members in family, amount of organic fertilizer applied, irrigated land area, and soil fertility status of farmland were the significant determinants of agricultural crop productivity. To increase the production and productivity of smallholder farms, the farmers were provided with land irrigation. Based on these findings, the study recommends the provision of organic fertilizer to farmers. Policies should also target supplying improved technology and improved seed to enhance agricultural crop production in Ethiopia.
Numerical Analysis of Flow in a Transonic Compressor With a Single Circumferential Casing Groove: Influence of Groove Location and Depth on Flow Instability

The effect of circumferential single grooved casing treatment on the stability enhancement of NASA Rotor 37 has been examined with CFD analysis. Stall inception mechanism of Rotor 37 is presented first with principal focus on the tip leakage flow behavior, passage blockage, and the vortical flow structures. Detailed observation showed that the combined interaction of the stagnated flow of tip leakage vortex breakdown and the jet-like leakage flow from the mid-chord region leads to the blade tip-initiated stall inception. The result of numerical parametric study is then demonstrated to show the effect of varying the axial location and the depth of a circumferential single groove. The evaluation based on stall margin improvement showed a higher potential of deeper grooves in stability enhancement, and the optimal position for the groove to be located was indicated to exist near the leading edge of the blade.Copyright © 2013 by ASME
On the all-India rainfall index and sub-India rainfall heterogeneity

We revisit long-standing controversies regarding relationships among the all-India rainfall index (AIRI), sub-India summer rainfall variations, El Ni\~no-Southern Oscillation (ENSO), and the Indian Ocean Dipole (IOD) using 120-year sea surface temperature and high-resolution rainfall datasets. AIRI closely tracks with the spatial extent of wet anomalies and with the average across gridpoints in rainy day count. The leading rainfall variability mode is a monopole associated primarily with rainy day count and ENSO. The second mode is a tripole with same-signed loadings in the high-rainfall Western Ghats and Central Monsoon Zone regions and opposite-signed loadings in Southeastern India between. The IOD projects onto this tripole and, as such, is weakly correlated with AIRI. However, when the linear influence of ENSO is removed, the IOD rainfall regressions become quasi-homogeneously more positive, making the ENSO-residual IOD and AIRI timeseries significantly correlated.
A Window of Opportunity: Perilymph Sampling from the Round Window Membrane Can Advance Inner Ear Diagnostics and Therapeutics

In the clinical setting, the pathophysiology of sensorineural hearing loss is poorly defined and there are currently no diagnostic tests available to differentiate between subtypes. This often leaves patients with generalized treatment options such as steroids, hearing aids, or cochlear implantation. The gold standard for localizing disease is direct biopsy or imaging of the affected tissue; however, the inaccessibility and fragility of the cochlea make these techniques difficult. Thus, the establishment of an indirect biopsy, a sampling of inner fluids, is needed to advance inner ear diagnostics and allow for the development of novel therapeutics for inner ear disease. A promising source is perilymph, an inner ear liquid that bathes multiple structures critical to sound transduction. Intraoperative perilymph sampling via the round window membrane of the cochlea has been successfully used to profile the proteome, metabolome, and transcriptome of the inner ear and is a potential source of biomarker discovery. Despite its potential to provide insight into inner ear pathologies, human perilymph sampling continues to be controversial and is currently performed only in conjunction with a planned procedure where the inner ear is opened. Here, we review the safety of procedures in which the inner ear is opened, highlight studies where perilymph analysis has advanced our knowledge of inner ear diseases, and finally propose that perilymph sampling could be done as a stand-alone procedure, thereby advancing our ability to accurately classify sensorineural hearing loss.
Tissue Engineered Transcatheter Pulmonary Valved Stent Implantation: Current State and Future Prospect

Patients with the complex congenital heart disease (CHD) are usually associated with right ventricular outflow tract dysfunction and typically require multiple surgical interventions during their lives to relieve the right ventricular outflow tract abnormality. Transcatheter pulmonary valve replacement was used as a non-surgical, less invasive alternative treatment for right ventricular outflow tract dysfunction and has been rapidly developing over the past years. Despite the current favorable results of transcatheter pulmonary valve replacement, many patients eligible for pulmonary valve replacement are still not candidates for transcatheter pulmonary valve replacement. Therefore, one of the significant future challenges is to expand transcatheter pulmonary valve replacement to a broader patient population. This review describes the limitations and problems of existing techniques and focuses on decellularized tissue engineering for pulmonary valve stenting.