Miracle-dz/UniFAR-FTUs huggingface dataset:
When Equity Factors Drop Their Shorts

Although factor premiums originate in both long and short legs of factor portfolios, we found that (1) most added value comes from the long legs, (2) the long legs offer more diversification than the short legs, and (3) the performance of the short legs is generally subsumed by that of the long legs. These results are robust over size, time, and markets and cannot be attributed to differences in tail risk. We also found that the claim that the value and low-risk factors are subsumed by the new (post-2015) Fama–French factors does not hold for the long legs of these factors. Disclosure: The authors disclose that they are employed by Robeco, a firm that offers various investment products. The construction of these products may, at times, draw on insights related to this research. No other person or party at Robeco except the authors had the right to review this article prior to its circulation. The views and results presented in this article were not driven by the views or interests of Robeco and are not a reflection of its points of view. Editor’s Note Submitted 21 November 2019 Accepted 29 May 2020 by Stephen J. Brown This article was externally reviewed using our double-blind peer-review process. When the article was accepted for publication, the authors thanked the reviewers in their acknowledgments. Malcolm Baker and one anonymous reviewer were the reviewers for this article.
The Intention of Adopting Information Technology for SMES in Special Region of Yogyakarta

This study aims to examine the intention of adopting information technology for SMEs in DIY through the expansion of the technology acceptance model. This research continues the previous research related to aspects of obstacles experienced in the development of SME businesses. The research conducted a survey using a sample of SMEs entrepreneurs in DIY. The data analysis technique in this study uses structural equation models that are assisted by the AMOS program. Overall, the expansion model of the technology acceptance model in predicting the intention of adopting SME’s information technology in this study fulfils the model fit rules, which means that the model developed in this study is by existing empirical conditions. In particular, the results of the study prove the influence of business competition pressure on the usefulness of SME owners. It also found that ease of use and perceived usefulness have an effect on the attitudes towards SMEs information technology adoption of SMEs owners, and the attitudes on the adoption of SMEs information technology affect the intention of adopting SME’s information technology.
Sero-prevalence of Human Cytomegalovirus among blood donors in Lahore, Pakistan

Background: Transfusion-transmitted cytomegalovirus (TT-CMV) infection can cause severe illness and even death among immunocompromised patients; therefore, the spread of CMV through blood products should be prevented. To our knowledge, no study has been carried out in Pakistan to determine the seroprevalence of CMV in general population as well as among blood donors. The goal of this study was to determine CMV seropositivity among blood donors at the blood bank of INMOL Hospital, Lahore, Pakistan. Methods: A sero-epidemiological cross-sectional study was conducted. Sera from 91 blood donors were screened for CMV specific IgG antibodies by enzyme-linked immunosorbent assay (ELISA) based kit. Results: The CMV-specific IgG antibodies were detected in 89 blood donors, which gave seroprevalence rate of 97.8%. The statistical analysis of results was done using pearson chi-square test and appeared non-significant with values 0.625 and 0.705 for different age groups and blood groups of donors. Conclusion: Because of high seroprevalence in this study area, an adequate supply of CMV seronegative blood is difficult to maintain. Therefore, we propose that the future strategies for the prevention of post-transfusion CMV infection in recipients should include the transfusion of leukoreduced blood products. Further a prospective study with much greater population can be done to identify major causative risk factors for such highest prevalence rate.
Improving Turbine Performance: A Contribution to the Understanding of Heat Transfer and Vortical Structures in Staggered Pin Fin Arrays

Through the comparison of flow structures, velocity contours, turbulence statistics, and additional flow quantities, the error sources of RANS are qualitatively described. The findings in this work will help gas turbine design engineers to tweak their turbulence models and give guidance on the interpretation of their results. The novelty is the application of the transient TLC method on this type of geometry as well as the near-wall PIV measurements. The advancements in additive manufacturing disrupt the classic turbine cooling development for casted airfoils. More and more complicated shapes and cooling schemes are possible. Nonetheless, a detailed physical understanding of fundamental cases as provided in this study is required for physics-based optimization of cooling designs.
Blood banks and their effectiveness in addressing disasters: a case of the Kenyatta National Hospital

iii ACKNOWLEDGEMENTS . v LIST OF ACRONYMS . vi TABLE OF CONTENTS . vii LIST OF FIGURES . xii LIST OF TABLES . xiii LIST OF GRAPHS . xiii CHAPTER ONE: INTRODUCTION . 1 1.1 Background to the study . 1 1.2 Statement of the problem . 2 1.3 Research questions . 4 1.4 General objective . 5 1.4. 1 Specific objectives of the research . 5 1.5 Justification of the study . 5 1.6 Scope and limitation of the study. 6 1.7 Definition of terms . 7
Retinopathy of prematurity: a study of incidence and risk factors -

Background: A historic cohort observational study was conducted between 2009-2014 in NICU of a tertiary care hospital to study the incidence and risk factors predisposing to retinopathy of prematurity (ROP) using wide field digital fundus camera. Methods: Preterm babies with birth weight < 2000 g and gestation ≤ 34 weeks were screened for ROP at 2-3 weeks after birth. Babies with gestation > 34 weeks were screened only if they had additional risk factors. Those meeting early treatment for ROP study guidelines (ETROP) were treated by laser. Results: The incidence of ROP in the 154 babies who were screened using wide field digital fundus camera was 28.57% (44 babies) and incidence of severe ROP was 4.5% (7 babies). All babies with severe ROP were treated with laser photocoagulation. The mean gestational age of ROP babies was 30.1(±1.9) weeks; 39 (88.6%) were ≤ 32 weeks and 5 (11.4%) were >32 weeks. As the gestational age decreased, the incidence of ROP increased (P = 0.001). Birth weight of ROP babies ranged from 628 gm to 1650 g with a mean of 1160 (±230) g. The incidence of ROP in infants ≤1250 gm was 55.1% and >1250 was 16%. On multivariate analysis the higher incidence of risk factors such as RDS, blood transfusion, apnea, low birth weight and low gestational age (prematurity) were independent and significant determinants of ROP (P-value < 0.05 for all) while anaemia requiring blood transfusion and apnea were significant risk factors for severe ROP. Conclusions: ROP screening can be effectively done by using RETCAM. Risk factors predisposing to ROP were apnea, respiratory distress syndrome, anemia requiring blood transfusion, low birth weight and low gestational age (prematurity) while anemia requiring blood transfusion and apnea were significant risk factors for severe ROP.
Prediction of Risk Delay in Construction Projects Using a Hybrid Artificial Intelligence Model

Project delays are the major problems tackled by the construction sector owing to the associated complexity and uncertainty in the construction activities. Artificial Intelligence (AI) models have evidenced their capacity to solve dynamic, uncertain and complex tasks. The aim of this current study is to develop a hybrid artificial intelligence model called integrative Random Forest classifier with Genetic Algorithm optimization (RF-GA) for delay problem prediction. At first, related sources and factors of delay problems are identified. A questionnaire is adopted to quantify the impact of delay sources on project performance. The developed hybrid model is trained using the collected data of the previous construction projects. The proposed RF-GA is validated against the classical version of an RF model using statistical performance measure indices. The achieved results of the developed hybrid RF-GA model revealed a good resultant performance in terms of accuracy, kappa and classification error. Based on the measured accuracy, kappa and classification error, RF-GA attained 91.67%, 87% and 8.33%, respectively. Overall, the proposed methodology indicated a robust and reliable technique for project delay prediction that is contributing to the construction project management monitoring and sustainability.
Effects of Moisture Initialization on MJO and its Teleconnection Prediction in BCC Subseasonal Coupled Model

It is well recognized that moisture is of great importance in the representation of the Madden‐Julian Oscillation (MJO). In this study, a moisture initialization scheme is developed using the Beijing Climate Center (BCC) subseasonal operational coupled model, and its effects on MJO predictions are investigated. Three sets of hindcast experiments are conducted: a reference experiment without moisture initialization (REF) and two sensitivity experiments with moderate and strong moisture nudging schemes. We show that the prediction skill of the real‐time multivariate MJO index is significantly improved in the two sensitivity experiments, where the skillful prediction can reach up to 20 days using the moderate nudging scheme. Larger improvements can be achieved when MJO was initiated from Phases 2–3 and 5–7 or during La Niña episodes, implying that the MJO prediction skill is more sensitive to moisture conditions in active convection regions and backgrounds. The moisture budget analysis indicated that the MJO prediction improvement using the moisture initialization schemes comes from the realistic representation of vertical moisture structure and vertical moisture advection to the east of the MJO convection in the planetary boundary layer. The improved MJO prediction is also demonstrated to enable a more reliable subseasonal prediction of extratropical circulation and precipitation through a more realistic description of MJO‐related teleconnections. In addition, the ensemble mean of the three schemes can extend the MJO prediction skill to more than 22 days, showing the potential benefits of ensemble prediction of multiinitialization schemes.
Variation in Nicotine and Nitrosamine Pharmacology Genes and Smoking-associated Lung Cancer

Lung cancer is the leading cause of death from cancer in North America. While the vast majority of lung cancer cases are attributable to cigarette smoke exposure, among smokers there are substantial differences in the risk for lung cancer even taking into account cigarettes per day and years of smoking. Identifying and characterizing genetic factors that influence the relationship between smoking and lung cancer continues to be a priority. Among the thousands of chemicals in cigarette smoke, nicotine is critical in establishing and maintaining smoking behaviours, while nitrosamines are an important class of carcinogens that require metabolic processing by the body to exert their full carcinogenicity. Owing to the structural similarities between nicotine and nitrosamines, these chemicals interact with many of the same enzymes and receptors in the body. We demonstrate that genetic variation in the nicotine/nitrosamine metabolizing genes, CYP2A6 and CYP2B6, and in the nicotinic receptor subunit genes, CHRNA5-CHRNA3-CHRNB4, influence lung cancer risk among smokers, and that individuals with high-risk genotypes at more than one gene locus are at even greater risk of lung cancer. Importantly, CYP2A6 and CHRNA5CHRNA3-CHRNB4 remain significantly associated with lung cancer risk after adjusting for daily cigarette consumption, suggesting that variation in these genes may be affecting lung cancer risk by influencing the carcinogenicity of nicotine/nitrosamines in addition to influencing carcinogen iii exposure through smoking behaviours. While these findings were in European Americans, a typically heavy smoking population, African Americans, a typically light smoking population, appear to suffer disproportionately from lung cancer risk. We demonstrate that variation in CYP2A6 also significantly influences lung cancer risk in this population. The findings from these studies implicate altered nicotine and nitrosamine pharmacology in the mechanism of lung carcinogenesis among smokers and may help inform the identification of smokers at increased risk of developing lung cancer, as well as inform the discovery of novel drug targets for lung cancer prevention and treatment.
Review of transport for London’s ‘Healthy Streets Approach’ and its potential contribution to biophilic cities

ABSTRACT The Mayor’s Transport Strategy and Draft London Plan promote the delivery of healthier streets through the new ‘Healthy Streets Approach’. This is a framework which integrates health into planning and design decisions and promotes a collaborative approach between transport specialists and designers. Through examples and the authors’ professional experience, this paper will explore how further development of this innovative new planning tool could help lead to the delivery of biophilic cities.
Chronic pain and use of analgesics in the elderly: a nationwide population-based study

Introduction Chronic pain may cause many comorbidities in the elderly; however, nationwide data about this issue remain insufficient. We conducted this study to address the data gap. Material and methods We identified geriatric participants (≥ 65 years) with chronic pain between 2000 and 2013 from the Taiwan National Health Insurance Research Database. The causes of chronic pain and use of analgesics between two sexes and among three age subgroups were compared. Results A total of 21,018 participants were identified with the mean age (standard deviation) of 72.7 years (5.6) and the female percentage of 50.8%. The prevalence of chronic pain in the elderly was 21.5%, and it was higher in the females than males. The proportions of each age subgroup were 65–74 (66.8%), 75–84 (29.4%), and ≥ 85 years (3.8%). Common causes of chronic pain were osteoarthritis (21.9%), spinal disorders (19.0%), peripheral vascular diseases (12.4%), and osteoporosis (11.4%). Non-steroidal anti-inflammatory drugs were the most common medication, followed by acetaminophen and opioids. The most commonly used opioid was morphine. The use of opioids increased with age. Conclusions This study delineated the causes of chronic pain and use of analgesics in a geriatric population, which may help further studies about this issue in the future.
Hyperoxemia reduces cerebrovascular accidents post coronary artery bypass graft surgery: a retrospective cohort study

Cerebrovascular accidents (CVAs) including strokes and transient ischaemic attacks (TIAs) form a major portion of perioperative morbidity in patients undergoing coronary artery bypass graft (CABG) surgery. The aim of this article was to: (I) to examine the relationship between providing increased intraoperative partial pressure of arterial oxygen (PaO 2 ) and the risk of perioperative CVA following CABG surgery; (II) to examine the relationship between intraoperative PaO 2 and other perioperative adverse outcomes. This was a retrospective cohort study involving 2,253 consecutive CABG patients located within a single cardiothoracic unit of a tertiary hospital. All patients underwent CABG surgery. A multivariate analysis was undertaken to assess the relationship between the PaO 2 (intra-operative mean and nadir) and its associated risk of perioperative CVA. Results were reported as odds ratios (OR) with 95% confidence interval (95% CI). There was a significant (but clinically limited) inverse correlation between average intra-operative PaO 2 and reducing peri-operative CVA (OR 0.99; P=0.029; 95% CI: 0.98–1.00), indicating a reduction in stroke risk with increasing PaO 2 . There was no significant association with PaO 2 nadir and CVA. There was no significant association between increasing hyperoxia and the following adverse events: pneumonia, prolonged postoperative ventilation, perioperative myocardial infarction or cardiac arrest, sternal wound infection, sepsis and renal failure. We report a significant inverse correlation between increasing average intra-operative PaO 2 and reducing peri-operative CVA. Further, hyperoxia was not associated with any adverse effects or infective outcomes. This finding is likely to have preventative and therapeutic implications through reducing stroke risk.
Incremental Nonlinear Dynamic Inversion for the Apache AH-64 Helicopter Control

Incremental nonlinear dynamic inversion (INDI)-based controller is a promising technique that can be adopted to control dynamic systems with high nonlinearities and extended cross-coupling effects. This paper presents the incremental strategy adopted as a sensor-based controller approach for the Apache AH-64D Longbow helicopter. The strength of the INDI sensor– based approach is that it does not require a detailed vehicle model as it uses only a control effectiveness model and estimates of the vehicle angular accelerations replacing the rest of the model. The weakness is its sensitivity to measurement and actuator delays, demanding additional estimations of model parameters and control effectiveness tuning. Using the Boeing FLYRT Apache model to simulate the vehicle dynamics, the paper has developed three adaptation schemes connecting the INDI sensor–based approach to the Apache partial control authority set as ±20% authority in all axes. The goal was to redesign the existing Apache's flight control systems and demonstrate handling qualities improvements for hover and low-speed flight in normal and degraded visual environment. Implementing the attitude command attitude hold and translational rate command response types in the system through the INDI controller, the paper demonstrates that improvements from Level 2 to Level 1 handling qualities can be achieved when flying the Aeronautical Design Standard-33 (ADS-33E-PRF) hover and pirouette maneuvers in a degraded visual environment.
Synthetic Growth Hormone-Releasing Hormone Agonist as Novel Treatment for Heart Failure with Preserved Ejection Fraction

Objective To test the hypothesis that the activation of the growth hormone-releasing hormone (GHRH) receptor signaling pathway within the myocardium both prevents and reverses heart failure with preserved ejection fraction (HFpEF). Background HFpEF is characterized by impaired myocardial relaxation, fibrosis and ventricular stiffness. Despite the rapidly increasing prevalence of HFpEF, no effective therapies have emerged. Synthetic agonists of the GHRH receptors reduce myocardial fibrosis, hypertrophy and improve performance, independently of the growth-hormone axis. Methods We generated a HFpEF-like phenotype with continuous infusion of angiotensin-II (Ang-II) in CD1 mice. Mice were injected with either vehicle or a potent synthetic agonist of the growth hormone-releasing hormone, MR-356. Results Ang-II treated animals had diastolic dysfunction, ventricular hypertrophy, and normal ejection fraction and isolated cardiomyocytes (ex vivo) exhibited incomplete relaxation, depressed contractile responses and altered myofibrillar protein phosphorylation. Calcium handling mechanisms were disturbed in cardiomyocytes from mice with HFpEF. MR-356 both prevented and reversed the development of the pathological phenotype in vivo and ex vivo. Conclusion These findings indicate that the GHRH receptor signaling pathway represents a new molecular target to counteract HFpEF-associated cardiomyocyte dysfunction by targeting myofilament phosphorylation. Accordingly, activation of the GHRH receptor with potent synthetic GHRH agonists may provide a novel therapeutic approach to management of the HFpEF syndrome. Condensed abstract Heart failure with preserved ejection fraction (HFpEF) is characterized by a remodeled myocardium conferring ventricular stiffness and diastolic dysfunction. There are no effective therapies. Agonists of growth hormone-releasing hormone (GHRH) receptors have beneficial effects on the heart. We hypothesize that activation of GHRH receptors suppresses this HFpEF phenotype. Treatment with a synthetic agonist of GHRH, prevented the development of the pathological phenotype in a murine model of HFpEF-induced by chronic angiotensin-II infusion. These findings indicate that activation of GHRH receptors represents a novel molecular strategy to counteract HFpEF-associated cardiomyocyte dysfunction and provide a potential approach to management of HFpEF syndrome. Highlights A synthetic growth hormone-releasing hormone agonist (GHRH-A) prevents and reverses the pathological remodeling in a mouse model of HFpEF induced by infusion of low dose Ang II. GHRH-A improves intracellular calcium handling by reducing the sarcoplasmic reticulum calcium leakage and enhancing phospholamban phosphorylation. GHRH-A treatment prevents and reverses diastolic dysfunction by enhancing the rate of sarcomere re-lengthening. Activation of the GHRH receptor with the GHRH-A, MR-356, leads to targeting myofibrillar proteins and desensitizing myofilaments in response to calcium.
Social media brand engagement: dimensions, drivers and consequences

This paper aims to advance the current understanding of social media (SM) brand engagement. Specifically, it validates the dimensionality of SM brand engagement, examines its drivers and explores the impact of SM brand engagement on brand equity. ,A survey was conducted with 433 Generation Y (Gen Y) SM users. ,The study results validate SM brand engagement as a multidimensional construct comprising utilitarian, hedonic and social dimensions. Three categories of SM engagement antecedents were identified: social factors (social identity and tie-strength), user-based factors (service, product and price information, hedonic motives and prior experience with SM) and firm-generated information (personalized advertising, mass advertising, promotional offers and price information). Finally, SM brand engagement was positively related to brand equity. ,This study focused on Gen Y SM users in India. This study should be replicated in other contexts to establish the generalizability of the findings. ,A better understanding of the dimensionality and drivers of SM brand engagement can help managers to enhance their SM strategies to build brand equity. ,This is the first study to provide a comprehensive examination of the dimensions, drivers and consequences of SM brand engagement.
HUBUNGAN POLA MAKAN DAN AKTIVITAS FISIK DENGAN STATUS GIZI SISWI KELAS VII SMP NEGERI (FULL DAY SCHOOL)

Upaya pemerintah dalam meningkatkan mutu pendidikan salah satunya adalah melalui program full day school. Full day school dimulai pada pagi hari hingga sore hari. Waktu yang relatif lama mengharuskan siswi mengikuti segala kegiatan pembelajaran di sekolah yang mengakibatkan aktivitas siswi menjadi padat sehingga berdampak pada kesulitan siswi dalam mengatur waktu istirahat dan pola makannya. Pola makan yang tidak teratur dapat memberikan dampak terhadap status gizi siswi. Penelitian ini dilakukan untuk mengetahui hubungan pola makan dan aktivitas fisik dengan status gizi siswi kelas VII SMP Negeri full day school Kota Malang. Rancangan pada penelitian ini menggunakan metode penelitian korelasional dengan desain penelitian cross sectional. Sampel yang digunakan sebanyak 100 siswi dengan teknik stratified random sampling. Analisis data menggunakan uji korelasi spearman. Hasil dari penelitian ini menunjukkan adanya hubungan yang signifikan antara pola makan dengan status gizi siswi dengan dengan p value 0,000 dan koefisien korelasi sebesar 0,406.Juga menunjukkan adanya hubungan yang signifikan antara aktivitas fisik dengan status gizi siswi dengan p value 0,000 dan koefisien korelasi sebesar -0,348.