Miracle-dz/UniFAR-FTUs huggingface dataset:
A Modeling Study of a Low-Level Jet along the Yun-Gui Plateau in South China

AbstractIn this study, the three-dimensional structures and diurnal evolution of a typical low-level jet (LLJ) with a maximum speed of 24 m s−1 occurring in the 850–800-hPa layer are examined using both large-scale analysis and a high-resolution model simulation. The LLJ occurred on the eastern foothills of the Yun-Gui Plateau in south China from 1400 LST 29 June to 1400 LST 30 June 2003. The effects of surface radiative heating, topography, and latent heat release on the development of the LLJ case are also studied. Results show that a western Pacific Ocean subtropical high and a low pressure system on the respective southeast and northwest sides of the LLJ provide a favorable large-scale mean pressure pattern for the LLJ development. The LLJ reaches its peak intensity at 850 hPa near 0200 LST with wind directions veering from southerly before sunset to southwesterly at midnight. A hodograph at the LLJ core shows a complete diurnal cycle of the horizontal wind with a radius of 5.5 m s−1. It is found that.
FLEXICURITY – LABOUR MARKET PERFORMANCE

Unemployment is at a low and stable level in Denmark. This achievement is often attributed to the so-called flexicurity model combining flexible hiring and firing rules for employers with income security for employees. Whatever virtues this model may have, a low and stable unemployment rate is not automatically among them since the basic flexicurity properties were also in place during the 1970s and 1980s where high and persistent unemployment was prevalent. Labour market performance has changed due to a series of reforms during the 1990s, the main thrust of which were a shift from a passive focus of labour market policies to a more active focus on job search and employment. The policy tightened eligibility for unemployment benefits and their duration as well as introduced workfare elements into unemployment insurance and social policies in general. Thereby policy makers attempted to strengthen the incentive structure without taking resort to general benefit reductions. We argue that the workfare policies have played an important role running primarily via motivation/threat and wage effects. However, active labour market policies are resource demanding, and although the workfare reforms have improved cost effectiveness, there is still an issue as to whether the resources going into active labour market policies are used efficiently. JEL Code: J30, J40, J60, H53. Torben M. Andersen School of Economics and Management University of Aarhus 8000 Aarhus Denmark tandersen@econ.au. dk Michael Svarer School of Economics and Management University of Aarhus 8000 Aarhus Denmark August 2007 This paper is based on presentations on the Danish flexicurity model in various places, including the Danish Ministry of Finance, Danmarks Nationalbank, the Swedish Ministry of Labour, the EU commission, and an IMF-workshop. We thank for comments and suggestions which have significantly influenced this paper. We thank Birgitte Højklint for reading the manuscript.
ON THE NOTION OF STRONG IRREDUCIBILITY AND ITS DUAL

This note gives a unifying characterization and exposition of strongly irreducible elements and their duals in lattices. The interest in the study of strong irreducibility stems from commutative ring theory, while the dual concept of strong irreducibility had been used to define Zariski-like topologies on specific lattices of submodules of a given module over an associative ring. Based on our lattice theoretical approach, we give a unifying treatment of strong irreducibility, dualize results on strongly irreducible submodules, examine its behavior under central localization and apply our theory to the frame of hereditary torsion theories.
DMSO_A_273339 3773..3786

1Department of Clinical Nursing, Faculty of Health Science, Wroclaw Medical University, Wroclaw, Poland; 2Faculty of Health Sciences, University of BielskoBiala, Bielsko-Biala, Poland; 3Department of Nursing, Faculty of Health Sciences, Palacký University Olomouc, Olomouc, Czech Republic; 4University Hospital Ostrava, Ostrava-Poruba, Czech Republic; 5National Institute of Cardiovascular Children’s Cardiology Center, Bratislava, Slovakia Introduction: The purpose of the paper was to perform a comparative analysis of the impact of T2DM on QoL, including specific ADDQoL domains and associations between QoL, selected socio-demographic factors (including gender, age, education, residence, marital status, professional activity) or clinical parameters (HbA1c levels, fasting blood glucose, BMI, duration of DM, complications, treatment used), in adult diabetic patients from Poland, the Czech Republic and Slovakia. The study group included 608 patients diagnosed with T2DM. There were 214 patients from Poland, 196 from the Czech Republic and 198 from Slovakia. Results: Overall, respondents from all three countries rated their QoL as good or very good. The mean scores for the item “If I did not have diabetes, my quality of life would be” were slightly higher for Poles than for Slovaks and Czechs. In the ADDQoL results, the weighted impact scores were negative for all domains. The lowest scores in all three countries were found for “freedom to eat„ for all patients; the highest for “living conditions”. For Polish patients, the linear regression model demonstrated the following significant AWI predictors: pre-university education and past smoking. For Czech patients, the linear regression model demonstrated that none of the characteristics analyzed were significant independent predictors of AWI. In the For Slovak patients, the linear regression model demonstrated the following significant AWI predictors: higher education and concurrent heart failure. Conclusion: In summary, our findings demonstrate that T2DM has a negative impact on all aspects of patients’ QoL, which is the strongest in terms of the freedom to eat and dietary habits, regardless of the country. Education, past smoking, and concurrent heart failure were the only independent predictors of QoL in our study. This suggests a need for further research that would include more variables and a larger number of patients.
Deceased Donation Through an Opt-Out System: A Libertarian Approach or Manipulation?, an a libertarian approach or

Citing this paper Please note that where the full-text provided on King's Research Portal is the Author Accepted Manuscript or Post-Print version this may differ from the final Published version. If citing, it is advised that you check and use the publisher's definitive version for pagination, volume/issue, and date of publication details. And where the final published version is provided on the Research Portal, if citing you are again advised to check the publisher's website for any subsequent corrections.
Novel T Cell Therapies for Multiple Myeloma

Multiple myeloma is a cancer of malignant plasma cells in the bone marrow and treatment has vastly improved in the last decade with the introduction of novel agents such as immunomodulatory drugs and proteasome inhibitors. New therapies are however required to eradicate residual disease and convert remission into cure. An increased understanding of immune defects in patients with myeloma has allowed for the development of immunotherapies that aim to unleash host T cells from tumour suppression and reactivate host immunity. Such T cell therapies are currently being trialled in patients producing promising results. In this review, we will describe the dysfunctional T cell landscape in myeloma, summarise the recent advances in T cell therapies and discuss future possibilities for myeloma treatment.
Knowledge, Attitude and Practice of Family Planning Among Scheduled Caste Women of Jorhat District, Assam

Background: Despite the fact that the usage of family planning methods has increased over a period of time, there exists a knowledge, attitude and practice gap among the peoples of various groups in our society regarding age, religion, caste, community etc. The objective of the study was to assess the level of knowledge, attitude, and practice of different family planning methods among the women of schedule caste community. Methods: A community based cross sectional study was done among 104 married women of the reproductive age group. Result: Most of the women (50%) were in the age group (25-34) years.77. 5% of the study participants were unemployed. Only 13.6% women had completed graduation. Average age at marriage was 19.73±3.813 years. Almost 96.1% women knew about any one method of contraception. The most common source of information was mass media (76.8%). 87.2% had positive attitude towards family planning. 65.7% females were using family planning methods currently. 25.4% were using traditional while 75.6% were using any type of modern methods. OCP is the most popular contraceptive method (47%) followed by condom (21.6%). Majority of females (40%) were using contraceptive methods for spacing of birth. 84% user said that they did not get any side effect. 53.3% women did not use any type of family planning method because they want children. Conclusion: Our study highlights that more strategic approach should be recommended to develop the socio-economic and demographic status in relation to fertility and family planning aspects for the people of scheduled caste community.
SARS-CoV-2 BA.4/5 Spike recognition and neutralization elicited after the third dose of mRNA vaccine

The SARS-CoV-2 Omicron BA.4 and BA.5 subvariants have recently emerged, with BA.5 becoming the dominant circulating strain in many countries. Both variants share the same Spike glycoprotein sequence which contains a large number of mutations, raising concerns about vaccine efficacy. In this study, we evaluated the ability of plasma from a cohort of individuals that received three doses of mRNA vaccine to recognize and neutralize the BA.4/5 Spike. We observed that BA.4/5 Spike is markedly less recognized and neutralized compared to the D614G and Omicron BA.2 Spike variants. Individuals who have been infected before or after vaccination present better humoral responses than SARS-CoV-2 naive vaccinated individuals, thus indicating that hybrid immunity generates better humoral responses against this subvariant.
Reproducibility Policies in Cardiology Journals: The REPLICA Cross-Sectional Study

Importance: Transparency and data sharing are valuable practices in research, contributing to improved precision and flexibility in cumulative evidence; and ultimately expanding the research ecosystem by addressing one of the philosophical research norms that implies that knowledge belongs to society. Objectives: The objective of the Reproducibility Policies In Cardiology Journals (REPLICA) study was to estimate the proportions of policies and guidance for reproducibility and transparency practices among Cardiology journals, as well as to determine details of completeness of reporting and data sharing conditions whenever disclosed. Design: Cross-sectional analysis. Setting: Cross-sectional study through analyses of journals deposited in the National Library of Medicine (NLM) Catalog tagged with the Cardiology and Vascular Diseases entry terms. Eligibility Criteria: Cardiology journals from the NLM Catalog database that published at least one randomized clinical trial in 2018. Journals that published articles in English, Spanish, French, or Portuguese and were available in MEDLINE/PubMed were eligible for inclusion. Exposures: The exposures were mainly related to journals characteristics such as publisher operations characteristics (e.g., journal access only by subscription), indexation in the DOAJPlus, requirement for registration for RCTs, and others. Main outcomes and measures: We prespecified a primary composite outcome composed of data-sharing policy or guidance. Secondary outcomes were proportions of reporting guidelines within the journals instructions for the authors section (e.g., CONSORT), and also other components of sharing practices. Results: We assessed 148 journals. Of them, 74 (50.0%, 95%CI 41.9% to 58.1%) presented policy or guidance for data sharing. We found guidance for data sharing in 68 journals (47.5% 95%CI 39.4% to 55.8%). Notably, among them, only two mentioned sharing individual participant data (IPD). Regarding guidelines for article reporting, we identified that 132 journals displayed guidance for authors, in which 27 (20.45%, 95%CI 14.34% to 28.29%) had CONSORT and EQUATOR Network guidance content. Conclusion and relevance: In summary, we found a mild proportion of policies and guidance for data-sharing. Moreover, transparency practices inclined to RCTs are suboptimal, as mirrored by the very low prevalence of IPD data-sharing policy and guidance as well as specific reporting guidelines instructions for RCTs.
Circular RNA hsa_circ_102209 promotes the growth and metastasis of colorectal cancer through miR-761-mediated Ras and Rab interactor 1 signaling

Background: The levels of hsa_circ_102209 in colorectal cancer (CRC) specimens and cells, as well as its effects on CRC cells were investigated. Methods: The expression of hsa_circ_102209 in CRC and paired non-cancerous samples, human CRC and normal colonic epithelial cells were examined using reverse transcription-quantitative polymerase chain reaction (RT-qPCR). Cells with hsa_circ_102209 knockdown were established using lentiviral vectors. Cell proliferative ability was evaluated using CCK-8 assay; cell migration and invasion were assessed by wound healing and Transwell assay. Cell cycle arrest and apoptosis were determined; apoptosis and EMT markers were examined using RT-qPCR and western blotting. Tumour development and levels of associated proteins were determined in hsa_circ_102209 knockdown mice. Results: Our results revealed that expression of hsa_circ_102209 was remarkably increased in CRC tissues, where the levels of miR-761 were notably reduced (p<0.05). Additionally, the levels of hsa_circ_102209 was associated with histology grade and occurrence of liver metastasis in CRC patients, and the expression of hsa_circ_102209 and miR-761 were negatively correlated (p<0.05). Moreover, hsa_circ_102209 was upregulated in CRC cells compared with normal colonic epithelial cells. Knockdown of hsa_circ_102209 notably inhibited the proliferation, migration, invasion and EMT of CRC cells (p<0.05), whereas enhanced cell cycle arrest at G0/G1 phase and apoptosis miR-761/Ras hsa_circ_102209 CRC hsa_circ_102209-modulated in CRC
Relative impact of residual cytogenetic abnormalities and flow cytometric measurable residual disease on outcome after allogeneic hematopoietic cell transplantation in adult acute myeloid leukemia

Measurable residual disease (MRD) before hematopoietic cell transplantation (HCT) is an independent established prognostic factor in patients with acute myeloid leukemia (AML). Several methods exist to evaluate the presence of residual leukemia cells, but how these are used best in combination is unclear. In order to examine how residual cytogenetic abnormalities and MRD testing by multiparameter flow cytometry (MFC) may refine risk assessment before HCT, we analyzed 506 adults with cytogenetically abnormal AML who underwent both routine karyotyping and MFC MRD testing before receiving a first allograft while in morphologic remission. Testing for residual cytogenetic abnormalities and MFC MRD identified four groups of patients with differential relapse-free survival (RFS) (hazard ratio [HR]=1.63 for Cytoabnormal/MFCnegative [P=0.01, n=63], HR=3.24 for Cytonormal/MFCpositive [P<0.001, n=60], and HR=5.50 for Cytoabnormal/MFCpositive [P<0.001, n=56] with Cytonormal/MFCnegative as reference [n=327]) and overall survival (OS) (HR=1.55 for Cytoabnormal/MFCnegative [P=0.03], HR=2.69 for Cytonormal/MFCpositive [P<0.001], and HR=4.15 for Cytoabnormal/MFCpositive [P<0.001] with Cytonormal/MFCnegative as reference). Results were similar for patients who received myeloablative or non-myeloablative conditioning. C-statistic values were higher, indicating higher accuracy, when using pre-HCT cytogenetic and MFC MRD information together for prediction of relapse, RFS, and OS, rather than using either test result alone. This study indicates that residual cytogenetic abnormalities and MFC MRD testing provide complementary prognostic information for post-HCT outcomes in patients with cytogenetically abnormal AML undergoing allogeneic HCT.
Delivery mode and risk of gastrointestinal disease in the offspring

The global increase of individuals born by cesarean section with reported levels up to 20% of all deliveries, makes it important to study cesarean section and possible associations that can increase risk of subsequent diseases in children. The aim of the study was to evaluate if cesarean section is associated with increased risk of gastrointestinal disease later in life in a large population‐based cohort.
Recipient Management before Lung Transplantation

Lung transplantation is considered a viable treatment option for patients with end-stage lung disease. Recent decades have seen a gradual increase in the number of lung transplantation patients worldwide, and in South Korea, the case number has increased at least 3-fold during the last decade. Furthermore, the waiting list time is becoming longer, and more elderly patients (>65 years) are undergoing lung transplantation; that is, the patients placed on the waiting list are older and sicker than in the past. Hence, proper management during the pre-transplantation period, as well as careful selection of candidates, is a key factor for transplant success and patient survival. Although referring and transplant centers should address many issues, the main areas of focus should be the timing of referral, nutrition, pulmonary rehabilitation, critical care (including mechanical ventilation and extracorporeal membrane oxygenation), psychological support, and the management of preexisting comorbid conditions (coronary artery disease, diabetes mellitus, gastroesophageal reflux disease, osteoporosis, malignancy, viral infections, and chronic infections). In this context, the present article reviews and summarizes the pre-transplantation management strategies for adult patients listed for lung transplantation.
Treatment algorithm in Vancouver B2 periprosthetic hip fractures: osteosynthesis vs revision arthroplasty

There is currently a debate on whether all Vancouver B2 periprosthetic hip fractures should be revised. The aim of our work was to establish a decision-making algorithm that helps to decide whether open reduction and internal fixation (ORIF) or revision arthroplasty (RA) should be performed in these patients. Relative indications in favour of ORIF are low-medium functional demand (Parker mobility score (PMS) <5), high anaesthetic risk (American Society of Anesthesiologists score (ASA) ≥ 3), many comorbidities (Charlson Comorbidity Index (CCI) ≥ 5), 1 zone fractured (VB2.1), anatomical reconstruction possible, and no prior loosening (hip pain). Relative indications in favour of RA are high functional demand (PMS ≥6), low anaesthetic risk (ASA< 3), few comorbidities (CCI<5), fracture ≥ 2 zones (VB2.2), comminuted fractures, and prior loosening (hip pain). In cemented stems, those fractures with fully intact cement–bone interface, no stem subsidence into the cementraliser, cement mantle anatomically reducible, and some partial stem-cement attachment can be safely treated with ORIF.
Design, dynamic docking, synthesis, and in vitro validation of a novel DNA gyrase B inhibitor

Abstract Methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-intermediate-resistant Staphylococcus aureus (VRSA) are among the WHO's high priority pathogens. Among these two, MRSA is the most globally documented pathogen that necessitates the pressing demand for new classes of anti-MRSA drugs. Bacterial gyrase targeted therapeutics are unique strategies to overcome cross-resistance as they are present only in bacteria and absent in higher eukaryotes. The GyrB subunit is essential for the catalytic functions of the bacterial enzyme DNA Gyrase, thereby constituting a promising druggable target. The current study performed a structure-based virtual screening to designing GyrB target-specific candidate molecules. The de novo ligand design of novel hit molecules was performed using a rhodanine scaffold. Through a systematic in silico screening process, the hit molecules were screened for their synthetic accessibility, drug-likeness and pharmacokinetics properties in addition to its target specific interactions. Of the 374 hit molecules obtained through de novo ligand design, qsl-304 emerged as the most promising ligand. The molecular dynamic simulation studies confirmed the stable interaction between the key residues and qsl-304. qsl-304 was synthesized through a one-step chemical synthesis procedure, and the in vitro activity was proven, with an IC50 of 31.23 µg/mL against the novobiocin resistant clinical isolate, Staphylococcus aureus sa-P2003. Further studies on time-kill kinetics showed the bacteriostatic nature with the diminished recurrence of resistance. The on-target gyrB inhibition further proved the efficacy of qsl-304. Communicated by Ramaswamy H. Sarma
Trial of Prasinezumab in Early-Stage Parkinson's Disease.

BACKGROUND Aggregated α-synuclein plays an important role in the pathogenesis of Parkinson's disease. The monoclonal antibody prasinezumab, directed at aggregated α-synuclein, is being studied for its effect on Parkinson's disease. METHODS In this phase 2 trial, we randomly assigned participants with early-stage Parkinson's disease in a 1:1:1 ratio to receive intravenous placebo or prasinezumab at a dose of 1500 mg or 4500 mg every 4 weeks for 52 weeks. The primary end point was the change from baseline to week 52 in the sum of scores on parts I, II, and III of the Movement Disorder Society-sponsored revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS; range, 0 to 236, with higher scores indicating greater impairment). Secondary end points included the dopamine transporter levels in the putamen of the hemisphere ipsilateral to the clinically more affected side of the body, as measured by 123I-ioflupane single-photon-emission computed tomography (SPECT). RESULTS A total of 316 participants were enrolled; 105 were assigned to receive placebo, 105 to receive 1500 mg of prasinezumab, and 106 to receive 4500 mg of prasinezumab. The baseline mean MDS-UPDRS scores were 32.0 in the placebo group, 31.5 in the 1500-mg group, and 30.8 in the 4500-mg group, and mean (±SE) changes from baseline to 52 weeks were 9.4±1.2 in the placebo group, 7.4±1.2 in the 1500-mg group (difference vs. placebo, -2.0; 80% confidence interval [CI], -4.2 to 0.2; P = 0.24), and 8.8±1.2 in the 4500-mg group (difference vs. placebo, -0.6; 80% CI, -2.8 to 1.6; P = 0.72). There was no substantial difference between the active-treatment groups and the placebo group in dopamine transporter levels on SPECT. The results for most clinical secondary end points were similar in the active-treatment groups and the placebo group. Serious adverse events occurred in 6.7% of the participants in the 1500-mg group and in 7.5% of those in the 4500-mg group; infusion reactions occurred in 19.0% and 34.0%, respectively. CONCLUSIONS Prasinezumab therapy had no meaningful effect on global or imaging measures of Parkinson's disease progression as compared with placebo and was associated with infusion reactions. (Funded by F. Hoffmann-La Roche and Prothena Biosciences; PASADENA ClinicalTrials.gov number, NCT03100149.).