Miracle-dz/UniFAR-FTUs huggingface dataset:
Intergroup threat and affective polarization in a multi-party system

What explains affective polarization among voters and societal groups? Much of the existing literature focusing on mass political polarization in modern democracies originates in the US, where studies have shown that, while ideological separation has grown, political conflict increasingly reflects social identity divisions rather than policy disagreements, resulting in affective polarization. We focus on explaining such polarization in a multi-party context. Drawing on social identity theory and intergroup threat theory, we hypothesize that individuals who perceive an intergroup threat show stronger intergroup differentiation and increased affective polarization. We analyze the influence of perceived threat on affective polarization drawing on two large-scale representative surveys in Sweden (N = 1429 and 1343). We show that individual-level affective polarization is related to perceived intergroup threats among the voters in both studies, measuring affective polarization using social distance, negative trait attribution, and party like-dislike ratings.
Evaluation of an Enhanced Bank of Kalman Filters for In-Flight Aircraft Engine Sensor Fault Diagnostics

In this paper, an approach for in-flight fault detection and isolation (FDI) of aircraft engine sensors based on a bank of Kalman filters is developed. This approach utilizes multiple Kalman filters, each of which is designed based on a specific fault hypothesis. When the propulsion system experiences a fault, only one Kalman filter with the correct hypothesis is able to maintain the nominal estimation performance. Based on this knowledge, the isolation of faults is achieved. Since the propulsion system may experience component and actuator faults as well. a sensor FDI system must be robust in terms of avoiding misclassifications of any anomalies. The proposed approach utilizes a bank of (m+1) Kalman filters where m is the number of sensors being monitored. One Kalman filter is used for the detection of component and actuator faults while each of the other m filters detects a fault in a specific sensor. With this setup, the overall robustness of the sensor FDS system to anomalies is enhanced. Moreover, numerous component fault events can be accounted for by the FDI system. The sensor FDI system is applied to a nonlinear simulation of a commercial aircraft gas turbine engine, and its performance is evaluated at multiple power settings at a cruise operating point using various fault scenarios.
Involving supervisors in assessing undergraduate student projects: is double marking robust?

Abstract The individual student project is a significant piece of work, typically carried out in the final or penultimate year of an engineering programme. Its primary aim is to provide evidence of a student’s competence in applying the knowledge and experience gained over the entire engineering programme to practical engineering problem solving. Each student project is supervised by at least one academic. In many institutions, double marking involving project supervisors and non-supervisors is used to provide a summative assessment of student projects. This has raised concerns about potential supervisor bias. The work reported in this paper is a statistical investigation into potential supervisor bias in a double marking scheme in the engineering department of a UK university. In this scheme, 90 final year undergraduate engineering student projects were assessed by 24 supervisors and 20 non-supervisors (referred to in this paper as second markers). The findings from this analysis suggest that there is significant correlation between the marks awarded by project supervisors and second markers and that there is no statistically significant evidence to suggest that project supervisors mark and grade final year student projects differently from second markers. An analysis of the project assessment environment from a community of practice perspective leads to the conclusion that the practice of double marking, as widely applied in engineering project assessment, probably has sufficient feedback and control mechanisms to ensure minimal intermarker variability between project supervisors and second markers.
Spatio-temporal variation in dry season determines the Amazonian fire calendar

Fire is one of the main anthropogenic drivers that threatens the Amazon. Despite the clear link between rainfall and fire, the spatial and temporal relationship between these variables is still poorly understood in the Amazon. Here, we stratified the Amazon basin according to the dry season onset/end and investigated its relationship with the spatio-temporal variation of fire. We used monthly time series of active fires from 2003 to 2019 to characterize the fire dynamics throughout the year and to identify the fire peak months. More than 50% (32 246) of the annual mean active fires occurred in the peak month. In 52% of the cells, the peaks occurred between August–September and in 48% between October–March, showing well-defined seasonal patterns related to spatio-temporal variation of the dry season. Fire peaks occurred in the last two months of the dry season in 67% of the cells and in 20% in the first month of the rainy season. The shorter the dry season, the more concentrated was the occurrence of active fires in the peak month, with a predominance above 70% in cells with a dry season between one and three months. We defined a Critical Fire Period by identifying the consecutive months that concentrated at least 80% of active fires in the year. This period included two to three months between January and March in the northwest, and in the far north it lasted up to seven months, ending in March–April. In the south, it varied between two and three months, starting in August. In the northeast, it was three to four months, between August and December. By quantifying the role of the dry season in driving fire seasonality across the Amazon basin, we provide recommendations to monitor fire dynamics that can support decision makers in management policies and measures to avoid environmentally or socially harmful fires.
Evaluation of parameters affecting gamma passing rate in patient‐specific QAs for multiple brain lesions IMRS treatments using ray‐station treatment planning system

Abstract Purpose Using intensity‐modulated radiosurgery (IMRS) with single isocenter for the treatment of multiple brain lesions has gained acceptance in recent years. One of the challenges of this technique is conducting a patient‐specific quality assurance (QA), involving accurate gamma passing rate (GPR) calculations for small and wide spread‐out targets. We evaluated effects of parameters such as dose grid and energy on GPR using our clinical IMRS plans. Methods Ten patients with total of 40 volumetric modulated arc therapy (VMAT) plans were created in Raystation (V.8A) treatment planning system (TPS) for the Varian Edge Linac using 6 and 10 flattening filter‐free (FFF) beams and planned dose grids of 1 mm and 2 mm resulting in four plans with 6–10 targets per patient. All parameters and objectives except dose grid and energy were kept the same in all plans. Next, patient‐specific QAs were measured evaluating GPR with 10% threshold, 3%/3 mm objective, and an acceptance criterion of 95%. Modulation factors (MF) and confidence intervals were calculated. Two modes of measurements, standard density (SD) and high density (HD), were used. Results Generally, plans computed with 1 mm dose grid have higher GPRs than those with 2 mm dose grid for both energies used. The GPRs of 6 FFF plans were higher than those of 10 FFF plans. GPR showed no noticeable difference between HD and SD measurements. Negative correlation between MF and GPR was observed. The HD pass rates fall within the confidence interval of SD. Conclusion Calculated dose grid should be less than or equal to one‐third of distance to agreement, thus 1 mm planned dose grid is recommended to reduce artifacts in gamma calculation. GPR of SD and HD measurement modes is almost the same, which indicates that SD mode is clinically preferable for performing patient‐specific QAs. According to our results, using 6 FFF beams with 1 mm planned dose grid is more accurate and reliable for dose calculation of IMRS plans.
Inoculation route-dependent Lassa virus dissemination and shedding dynamics in the natural reservoir – Mastomys natalensis

ABSTRACT Lassa virus (LASV), a Risk Group-4 zoonotic haemorrhagic fever virus, affects sub-Saharan African countries. Lassa fever, caused by LASV, results in thousands of annual deaths. Although decades have elapsed since the identification of the Natal multimammate mouse (Mastomys natalensis) as a natural reservoir of LASV, little effort has been made to characterize LASV infection in its reservoir. The natural route of infection and transmission of LASV within M. natalensis remains unknown, and the clinical impact of LASV in M. natalensis is mostly undescribed. Herein, using an outbred colony of M. natalensis, we investigate the replication and dissemination dynamics of LASV in this reservoir following various inoculation routes. Inoculation with LASV, regardless of route, resulted in a systemic infection and accumulation of abundant LASV-RNA in many tissues. LASV infection in the Natal multimammate mice was subclinical, however, clinical chemistry values were transiently altered and immune infiltrates were observed histologically in lungs, spleens and livers, indicating a minor disease with coordinated immune responses are elicited, controlling infection. Intranasal infection resulted in unique virus tissue dissemination dynamics and heightened LASV shedding, compared to subcutaneous inoculation. Our study provides important insights into LASV infection in its natural reservoir using a contemporary infection system, demonstrating that specific inoculation routes result in disparate dissemination outcomes, suggesting intranasal inoculation is important in the maintenance of LASV in the natural reservoir, and emphasizes that selection of the appropriate inoculation route is necessary to examine aspects of viral replication, transmission and responses to zoonotic viruses in their natural reservoirs.
QoS in the internal supply chain: the next lever of competitive advantage and organisational performance

This article presents a research that examines the relationship of quality of service (QoS) and organisational performance in a manufacturing setting. There are few empirical studies that measure QoS in the manufacturing supply chain. A model linking QoS with organisational performance through intermediate variables of satisfaction, loyalty and competitive advantage is introduced and tested in the internal supply chain of three automotive organisations. The research design for this article includes a combination of literature review, exploratory interviews with scholars and practitioners, and a survey of 156 practitioners in three automotive companies in North India. Structural equation modelling has been used for data analysis. This research comes out with four factor scale for internal service quality and six-factor scale for external service quality. The research revealed that employee-driven QoS is a source of value addition that is positively linked with the organisational performance. This study would be of interest to manufacturing industry practitioners interested in internal and external service quality improvements. Future researchers could validate this scale, and empirically test the proposed model.
Comparing immunogenicity and protective efficacy of the yellow fever 17D vaccine in mice

ABSTRACT The live-attenuated yellow fever 17D (YF17D) vaccine is one of the most efficacious human vaccines and also employed as a vector for novel vaccines. However, in the lack of appropriate immunocompetent small animal models, mechanistic insight in YF17D-induced protective immunity remains limited. To better understand YF17D vaccination and to identify a suitable mouse model, we evaluated the immunogenicity and protective efficacy of YF17D in five complementary mouse models, i.e. wild-type (WT) BALB/c, C57BL/6, IFN-α/β receptor (IFNAR-/- ) deficient mice, and in WT mice in which type I IFN signalling was temporally ablated by an IFNAR blocking (MAR-1) antibody. Alike in IFNAR-/- mice, YF17D induced in either WT mice strong humoral immune responses dominated by IgG2a/c isotype (Th1 type) antibodies, yet only when IFNAR was blocked. Vigorous cellular immunity characterized by CD4+ T-cells producing IFN-γ and TNF-α were mounted in MAR-1 treated C57BL/6 and in IFNAR-/- mice. Surprisingly, vaccine-induced protection was largely mouse model dependent. Full protection against lethal intracranial challenge and a massive reduction of virus loads was conferred already by a minimal dose of 2 PFU YF17D in BALB/c and IFNAR-/- mice, but not in C57BL/6 mice. Correlation analysis of infection outcome with pre-challenge immunological markers indicates that YFV-specific IgG might suffice for protection, even in the absence of detectable levels of neutralizing antibodies. Finally, we propose that, in addition to IFNAR-/- mice, C57BL/6 mice with temporally blocked IFN-α/β receptors represent a promising immunocompetent mouse model for the study of YF17D-induced immunity and evaluation of YF17D-derived vaccines.
Effects of Age and Field-of-Viewon Spatial Learning in an Immersive Virtual Environment

Adults and middle elementary schoolchildren (7-9 years old) were taught a route through a six room virtual house, while wearing a helmet mounted display (HMD) and using a joystick to navigate the virtual environment (VE). Participants viewed the environment under monoscopic conditions with field-of-view (FOV) set at either 30° H × 22° V or 48° H × 36° V. Participants performed tasks designed to assess their spatial knowledge in terms of landmark knowledge, route knowledge, and three configuration knowledge metrics. Landmark knowledge did not significantly change with age or FOV (p > .05). As both age and FOV increased, route and configuration knowledge significantly increased (p < .05). The results are discussed in terms of designing VEs for children.
Presumptive Identification of Candida spp. from Clinical Isolates and Anticandidal Effect of Essential Oils

Candida is normal flora of human skin, mouth, vagina, colon and causes mycosis worldwide. Candida causes oral thrush, vaginitis and other potentially life-threatening diseases. This study assesses anticandidal potential of essential oils against Candida species isolated from clinical samples obtained from Mahatma Gandhi Institute of Medical Sciences, Sewagram, Wardha, Maharashtra. On the basis of morphological characterization on Sabouraud dextrose agar, CHROMagar, Germ tube test and biochemical characterization, Candida species identified as Candida albicans, Candida krusei, Candida glabrata, Candida parapsilosis. Clove, thyme, cinnamon and eucalyptus essential oils with concentrations of 6.2, 12.5, 25, 50 and 100 μg/ml were used to study their anticandidal activity. C. albicans demonstrated zone of inhibition (ZOI) 29, 20, 32, 29 mm, Candida krusei 25, 25, 30, 21 mm, Candida glabrata 24, 22, 31, 32mm,Candida parapsilosis 33,31,33, 29mm towards clove, thyme, cinnamon and eucalyptus oil (each at 100 μg/ml) respectively which are highest ZOI as compared with antifungal agent Amphotericin-B, which showed 16, 13, 12, 8 mm against C. albicans, C. krusei, C.glabrata and C. parapsilosis respectively. All Candida spp. produced biofilms and enzyme lipase. This study will facilitate the development of novel broad-spectrum key molecules against a range of Candida species.
Design, Fabrication, and Optimization of Jatropha Sheller

A study designed, fabricated, and optimized performance of a jatropha sheller, consisting of mainframe, rotary cylinder, stationary cylinder, transmission system. Evaluation and optimization considered moisture content, clearance, and roller speed as independent parameters while the responses comprised of recovery, bulk density factor, shelling capacity, energy utilization of sheller, whole kernel recovery, oil recovery, and energy utilization by extruder. Moisture content failed to affect the response variables. The clearance affected response variables except energy utilization of the extruder. Roller speed affected shelling capacity, whole kernel recovery, and energy utilization of the extruder. Optimization resulted in operating conditions of 9.5%wb moisture content, clearance of 6 mm, and roller speed of 750 rpm.
CTNI-55. THE CDK4/6 INHIBITOR ABEMACICLIB IN PATIENTS WITH RECURRENT MENINGIOMA AND OTHER PRIMARY CNS TUMORS

Medical therapies for recurrent brain tumors are limited. Abemaciclib is a small molecule CDK4/6 inhibitor that has demonstrated antitumor activity in multiple cancer types and crosses the blood-brain barrier. We conducted a phase II trial of single-agent abemaciclib in patients with recurrent primary brain tumors utilizing a novel CNS basket trial design with multiple tumor types accrued to separate cohorts including patients with recurrent IDH-wildtype gliomas (Cohort A), any recurrent gliomas requiring cytoreductive surgery (Cohort B), and any other recurrent primary brain tumors (Cohort C) including IDH-mutant gliomas, meningiomas, and other tumor types. In all patients, abemaciclib was administered orally at 200mg twice daily for each 28-day cycle. In cohort B abemaciclib was administered 4-7 days prior to surgery then resumed after recovery. Neuroimaging disease assessments were performed every two cycles. Cohorts were individually assessed for efficacy, tumoral molecular characteristics, and exploratory biomarker analyses. Next generation sequencing was performed on patients who had prior surgery. To date, a total of 61 patients have enrolled and initiated treatment with abemaciclib. Cohort A enrolled 9 patients with IDH-wildtype WHO grade II and III astrocytomas. Cohort B enrolled 10 patients with astrocytomas of varying IDH-status. Cohort C is a diverse group of 42 patients including 22 treatment-refractory meningiomas, 10 IDH-mutant gliomas (5 astrocytomas, 5 oligodendrogliomas), 3 ependymomas, 3 primary CNS lymphomas, 2 pituitary tumors, 1 glioneuronal rosette forming tumor, and 1 diffuse midline glioma. A total of 7 grade 3 toxicities occurred in 6 patients: fatigue (3), neutropenia (2), colitis (1) and seizure (1); no grade 4 toxicities occurred. We present the results of a novel CNS basket trial looking at the efficacy of abemaciclib across multiple recurrent primary brain tumors. Efficacy results will be presented, highlighting an update on promising results in the 22 patients with recurrent meningiomas.
Radiation of a rectangular microstrip patch antenna covered with a dielectric layer

The effect of a protecting dielectric superstrate on the radiation pattern of a rectangular microstrip patch antenna is investigated theoretically. The analysis approach is based on the spectral-domain method of moments in conjunction with the stationary phase method. A new concise expression is derived for computing the radiation electric field. The validity of the solution is tested by comparing the computed results with the experimental data. At higher superstrate thicknesses, numerical results indicate that the radiation pattern drastically changes into three lobes. The resonant frequency, on the other hand, increases with the increase of the thickness of the dielectric cover.
Amniotic Epithelial Stem Cells Counteract Acidic Degradation By-Products of Electrospun PLGA Scaffold by Improving Their Immunomodulatory Profile In Vitro

Electrospun poly(lactic-co-glycolic acid) (PLGA) scaffolds with highly aligned fibers (ha-PLGA) represent promising materials in the field of tendon tissue engineering (TE) due to their characteristics in mimicking fibrous extracellular matrix (ECM) of tendon native tissue. Among these properties, scaffold biodegradability must be controlled allowing its replacement by a neo-formed native tendon tissue in a controlled manner. In this study, ha-PLGA were subjected to hydrolytic degradation up to 20 weeks, under di-H2O and PBS conditions according to ISO 10993-13:2010. These were then characterized for their physical, morphological, and mechanical features. In vitro cytotoxicity tests were conducted on ovine amniotic epithelial stem cells (oAECs), up to 7 days, to assess the effect of non-buffered and buffered PLGA by-products at different concentrations on cell viability and their stimuli on oAECs’ immunomodulatory properties. The ha-PLGA scaffolds degraded slowly as evidenced by a slight decrease in mass loss (14%) and average molecular weight (35%), with estimated degradation half-time of about 40 weeks under di-H2O. The ultrastructure morphology of the scaffolds showed no significant fiber degradation even after 20 weeks, but alteration of fiber alignment was already evident at week 1. Moreover, mechanical properties decreased throughout the degradation times under wet as well as dry PBS conditions. The influence of acid degradation media on oAECs was dose-dependent, with a considerable effect at 7 days’ culture point. This effect was notably reduced by using buffered media. To a certain level, cells were able to compensate the generated inflammation-like microenvironment by upregulating IL-10 gene expression and favoring an anti-inflammatory rather than pro-inflammatory response. These in vitro results are essential to better understand the degradation behavior of ha-PLGA in vivo and the effect of their degradation by-products on affecting cell performance. Indeed, buffering the degradation milieu could represent a promising strategy to balance scaffold degradation. These findings give good hope with reference to the in vivo condition characterized by physiological buffering systems.
Asymptotic Optimality of Cp-Type Criteria in High-Dimensional Multivariate Linear Regression Models

We study the asymptotic optimality of Cp-type criteria from the perspective of prediction in high-dimensional multivariate linear regression models, where the dimension of a response matrix is large but does not exceed the sample size. We derive conditions in order that the generalized Cp (GCp) exhibits asymptotic loss efficiency (ALE) and asymptotic mean efficiency (AME) in such high-dimensional data. Moreover, we clarify that one of the conditions is necessary for GCp to exhibit both ALE and AME. As a result, it is shown that the modified Cp can claim both ALE and AME but the original Cp cannot in highdimensional data. The finite sample performance of GCp with several tuning parameters is compared through a simulation study.
AFLATOXICOSIS IN EMU (Dromaius novaehollandiae) CHICKS

The study was conducted in the emu chicks reared at Emu Research Unit, Regional Research Centr e, T amil Nadu Veterinary and Animal Sciences University, Pudukkottai during the year 2011. Emu chicks were kept in the brooder with a floor space of 4 sq.ft/chick. Emu chicks were offer ed emu starter mash from 5 th day onwards and water ad libitum. Chicks were showing gradual loss of appetite, lethargy, loss of weight, depression and ruffled feathers from 13 th day onwards. Two emu chicks died on subsequent days at the age of 17 and 21 days. Haemorrhage in the subcutis of the thigh region, enlarged liver with mottled and friable in consistency, distended pericardial sac with amber coloured fluid and congested intestinal and tracheal mucous membrane were r ecorded in the necropsy. Histologically, diffuse severe vacuolar changes of hepatocytes, congestion of epicardium with multifocal mild sub-acute epicarditis and diffuse mild congestion of trachea were obser ved. The feed sample was analysed for aflatoxin and it contained aflatoxin B 1 -45ppb and aflatoxin B 2 -20ppb. From this study, it can be concluded that aflatoxins in the feed caused death in the emu chicks after 13 and 17 days of feeding.