Miracle-dz/UniFAR-FTUs huggingface dataset:
Randomized, open label, phase III trial of figitumumab in combination with paclitaxel and carboplatin versus paclitaxel and carboplatin in patients with non-small cell lung cancer (NSCLC).

7500 Background: The Insulin-like growth factor type I receptor (IGF-IR) plays an important role in normal cellular growth and development and is implicated in the regulation of tumor growth. A phase III study was conducted to test the efficacy of the combination of paclitaxel, carboplatin, and figitumumab (CP-751871), a monoclonal antibody targeting the IGF-IR, as first-line treatment of advanced NSCLC. Methods: Eight hundred twenty pts were to be randomized 1:1 to receive paclitaxel (200 mg/m2), carboplatin (AUC = 6), and figitumumab (20 mg/Kg) (PCF) or paclitaxel and carboplatin alone (PC) q3weeks for up to 6 cycles. The primary study endpoint was overall survival (90% power, one sided 0.025 alpha, hazard ratio [HR] 0.77). Results: Accrual has been permanently suspended at 681 pts (median age 62 years, 77% male, 86% squamous cell carcinoma, 88% stage IV, 42% current smokers) enrolled based on a planned interim analysis at 225 events with a HR that crossed the prespecified futility boundary of 1.1 favor.
(E)-4-Hydroxy-N′-(4-hydroxy-3-methoxybenzylidene)benzohydrazide

In the title compound, C15H14N2O4, the N=C double bond has an E configuration. The two benzene rings make a dihedral angle of 28.59 (6)°. In the crystal, molecules are linked into a three-dimensional network by intermolecular N—H⋯O, O—H⋯O and C—H⋯O hydrogen bonds and stabilized by weak C—H⋯π interactions.
2-Phenyl-4-(p-toluidino­methyl­ene)-5-oxazolone

The two crystallographically independent mol­ecules in the asymmetric unit of the title compound, C17H14N2O2, have nearly the same molecular geometry. The planarity of the oxazoline ring is not affected by substitutions at the 2 and 4 positions. The structure is stabilized by N—H⋯O type intermolecular interactions.
Mobile phone interventions for adherence to treatment for diabetics in an urban area of Bangladesh

Background: Evidence suggests increasing prevalence of type 2 diabetes (T2D) in Bangladesh, imposing huge social and economic impacts. Mobile phone SMS have the potential to improve diabetes outcome. The research aimed to measure the clinical status and complications of T2D, mobile phone use and willingness-to-pay for diabetes SMS, effects of SMS on glycemic control, and healthcare use and expenditure for diabetes in Bangladesh. Methods: We conducted a cross-sectional study among 515 patients with T2D in a tertiary hospital in Dhaka and selected 236 patients meeting the eligibility criteria for a randomizedcontrolled trial of an SMS intervention. We further conducted a matched case-control study including 591 additional individuals with diagnosed diabetes and 591 age, sex and residence matched controls without diabetes at the same hospital. Results: The majority of patients with T2D had uncontrolled diabetes (71.3%) and selfreported complications (91.5%). In the randomized trial, the SMS intervention was effective with respect to the primary endpoint. Among the trial participants, the least squares mean difference of HbA1c from baseline to after 6 months was -0.85 (-1.05, -0.64) in the SMS group and -0.18 (-0.41, 0.04) in the control group. The difference between means was -0.66 (0.97, -0.35; p<0.0001). In the case-control study, patients with diabetes had two times more days of inpatient treatment, 1.3 times more outpatient visits, and 9.7 times more medications than those without diabetes (all p<0.005). The total annual per-capita healthcare expenditure was 6.12 times higher for persons with diabetes than non-diabetics (USD 635 vs. 104,
Poly[μ-2,3-dihydroxypropan-1-olato-sodium]

The Na+ cation in the title compound, [Na(C3H7O3)]n or Na[H2gl], is coordinated by five O atoms leading to a distorted trigonal-bipyramidal geometry. The negatively charged O atom of the glycerolate anion is in an equatorial position, and the O atom of the hydroxo group, attached to the secondary C atom, occupies an axial position completing a five-membered non-planar chelate ring; this defines the asymmetric unit. The Na+ cation is coordinated by three other symmetry-related monodentate H2gl− ligands, so that each H2gl− ligand is bonded to four Na+ ions. The H2gl− ligands are connected via strong O—H⋯O hydrogen bonds and these, together with the Na⋯O interconnections, are responsible for the formation of polymeric sheets which propagate in the directions of the b and c axes.
2-Chloro-N-(2,4-dimethylphenyl)acetamide

The conformation of the N—H bond in the structure of the title compound, C10H12ClNO, is syn to the ortho methyl group, similar to that observed with respect to the meta methyl group in 2-chloro-N-(3-methylphenyl)acetamide and the ortho-chloro group in 2-chloro-N-(2-chlorophenyl)acetamide. The geometric parameters are similar to those of other acetanilides. The molecules are linked into chains through intermolecular N—H⋯O hydrogen bonds.
(E)-N′-[(2-Hydroxy-1-naphthalen-1-yl)methylidene]-3-methylbenzohydrazide

In the title compound, C19H16N2O2, the benzene ring and naphthyl ring system are inclined at a dihedral angle of 16.1 (3)°. An intramolecular O—H⋯N hydrogen bond influences the molecular conformation. In the crystal, molecules are linked through N—H⋯O hydrogen bonds into chains running along the a axis.
Assessment of Antimicrobial Efficacy of MTAD, Sodium Hypochlorite, EDTA and Chlorhexidine for Endodontic Applications: An In vitro Study

2 Abstract: The key aim of endodontic treatment is to clean and debride the root canals and that is achieved biochemical and mechanical measures. Certain factors such as individual variations and complex anatomy and morphology of root canals have made debridement (both by mechanical and chemical means) a challenging task. The objective of this study was to evaluate the antimicrobial activity of recently introduced MTAD in vitro and comparing to commonly used irrigators such as NaOCl, chlorhexidine and EDTA under similar conditions and various pH levels. The results of this in vitro study were statistically analysed using Kruskal Wallis one-way ANOVA and Mann Whitney U test. It has been concluded that MTAD has the capability to eradicate E. faecalis.
2-Bromo-N-(dibenzylcarbamothioyl)benzamide

The 2-bromobenzoyl group in the title compound, C22H19BrN2OS, adopts an E conformation with respect to the thiono S atom across the N—C bond. In the crystal structure, the molecule is stablized by N—H⋯O intermolecular hydrogen bonds, forming a one-dimensional chain along the b axis.
(E)-1-(4-Aminophenyl)-3-(naphthalen-2-yl)prop-2-en-1-one

The molecule of the title chalcone derivative, C19H15NO, exists in a trans configuration with respect to the C=C double bond. The molecule is slightly twisted with a dihedral angle of 6.12 (12)° between the benzene ring and the naphthalene ring system. The prop-2-en-1-one bridge is nearly planar, with an r.m.s. deviation of 0.0194 (2), and makes dihedral angles of 8.05 (19) and 11.47 (18)° with the benzene ring and the naphthalene ring system, respectively. In the crystal, molecules are linked by N—H⋯O hydrogen bonds into chains along the b axis. Weak N—H⋯π and C—H⋯π interactions and a short N⋯O contact [2.974 (4) Å] are also observed.
6-Bromo-1,3-bis[(1,3-dioxolan-2-yl)methyl]-1H-imidazo[4,5-b]pyridin-2(3H)-one

In the title compound, C14H16BrN3O5, the N atoms adjacent to the carbonyl group in the five-membered ring are substituted by (1,3-dioxolan-2-yl)methyl groups. The fused ring system is essentially planar, with the largest deviation from the mean plane being 0.014 (2) Å for the C atom bearing the Br atom. The first oxolane ring, attached on the side of the N atom belonging to the pyridine ring, has an envelope conformation with one of the O atoms as the flap, whereas the second oxolane ring displays a twisted boat conformation. The two oxolane rings display envelope and twisted boat conformations. In the crystal, molecules are linked by C—H⋯O hydrogen bonds, building chains parallel to the a-axis direction.
A-Simple-and-Effective-Delay-Distribution-Analysis-for-IEEE-802.11

A simple, effective and accurate packet delay distribution analysis is presented for the IEEE 802.11 distributed coordination function (DCF). The packet delay distribution is effectively studied by developing an analytical model that calculates the probability that a packet is successfully transmitted after experiencing a delay time equal to a given value. The model uses simple mathematical relations and provides fast and accurate delay distribution curves. The accuracy of the analytical model is verified by simulations
4-(9-Anthryl)-1-(3-bromophenyl)spiro[azetidine-3,9′-xanthen]-2-one

In the title molecule, C35H22BrNO2, the four-membered ring of the β-lactam unit is nearly planar [maximum deviation = 0.003 (3) Å] and makes dihedral angles of 87.07 (15), 59.80 (16) and 20.81 (19)°, respectively, with the xanthene system, the anthracene system and the bromo-substituted benzene ring. The molecular conformation is stabilized by weak intramolecular C—H⋯O and C—H⋯N hydrogen bonds. The crystal structure features weak C—H⋯π interactions.
2-[(2,4-Dihydroxybenzylidene)amino]-3′,6′-bis(ethylamino)spiro[isoindoline-1,9′-xanthen]-3-one

The title compound, C35H36N4O4, was prepared as a spirolactam ring formation of rhodamine B dye for comparison with a ring-opened form. The xanthene ring system is approximately planar. The r.m.s. deviation from planarity is 0.064 (6) Å for the xanthene ring. The dihedral angles formed by the spirolactam and 2,4-dihydroxybenzene rings with the xanthene ring system are 86.6 (9) and 88.0 (9)°, respectively.
Dibromido[N-propyl-N′-(2-pyridylmethylidene)ethane-1,2-diamine]zinc(II)

The title complex, [ZnBr2(C11H17N3)], is a mononuclear zinc(II) compound derived from the Schiff base N-propyl-N′-(1-pyridin-2-ylmethylidene)ethane-1,2-diamine. The ZnII atom is five-coordinate, binding to the imine N, pyridine N, and amine N atoms of the Schiff base ligand and to two bromide anions in a distorted trigonal-bipyramidal coordination geometry. Adjacent molecules are linked through intermolecular N—H⋯Br hydrogen bonds, forming dimers.
2-Chloro-N-(3-methoxybenzoyl)benzenesulfonamide

In the title compound, C14H12ClNO4S, the dihedral angle between the chloro- and methoxy-substituted benzene rings is 87.40 (1)°. In the crystal, adjacent molecules form inversion-related dimers through strong N—H⋯O hydrogen bonds, generating R 2 2(8) loops. The dimers are further connected through two C—H⋯O interactions that form C(11) chains and R 2 2(14) loops. Aromatic π–π stacking interactions [centroid–centroid separation = 3.8574 (1) Å] are also observed.
1-[2,6-Dichloro-4-(trifluoro­meth­yl)phen­yl]-5-(4-methoxy­phenyl­sulfonamido)-1H-pyrazole-3-carbonitrile

The title mol­ecule, C18H11Cl2F3N4O3S, is a tricyclic amide with an overall Y shape. The dihedral angle between the pyrazole and attached benzene rings is 75.0 (1)°. In the crystal structure, an inter­molecular N—H⋯O hydrogen bond with an Namide⋯Osulfon­yl separation of 2.924 (5) A links the mol­ecules into linear chains along the a axis.
4-Methyl-N-(3-oxo-2,3-dihydro-1,2-benzisothiazol-2-yl)benzenesulfonamide

In the title molecule, C14H12N2O3S2, the benzisothiazolone ring system is essentially planar and forms a dihedral angle of 67.37 (6)° with the plane of the benzene ring. In the crystal structure, molecules are linked via intermolecular N—H⋯O and C—H⋯O hydrogen bonds to form chains parallel to the b axis.
Adoption of a Clinical Innovation "Best Practices for Concurrent Mental Health and Substance Use Disorders" in Ontario, a One-year Follow up

Objectives: To determine the level of adoption and which characteristics are most strongly associated with the adoption of a clinical innovation in Mental Health and Addiction Service organizations in Ontario, one year after dissemination. Methods: This cross-sectional study included a voluntary quantitative mail-out survey, using a self administered questionnaire that was sent to 260 mental health and addiction service organizations in Ontario. Linear regression analysis was conducted to identify significant predictors of the overall adoption-decision of the best practice recommendations. Results: Individuals‟ tenure within the organization and the provision of screening (organizational variable) was identified to be predictors of adoption for the organization. Conclusions: The results of this study demonstrated the majority of the organizations are on the path towards a finale decision of adopting or rejecting the recommendations. The results also demonstrate the importance of individual characteristics and organizational characteristics in identifying predictors of adoption.
catena-Poly[[triaqua­cadmium(II)]-μ2-pyrazine-2,3-dicarboxyl­ato]

The title CdII coordination polymer, [Cd(C6H2N2O4)(H2O)3]n, was synthesized by reacting Cd(NO3)2·3H2O and pyrazine-2,3-dicarboxylic acid under hydro­thermal conditions. Single-crystal X-ray studies reveal that self-assembly between the bridging ligands and metal ions results in a one-dimensional coordination polymer, in which the CdII ion is hepta-coordinated and shows a [CdNO6] penta­gonal–bipyramidal geometry.
1-(5-Chloro-6-fluoro-1,3-benzothiazol-2-yl)hydrazine

In the title compound, C7H5ClFN3S, the 1,3-benzothiazole ring system is nearly planar (r.m.s. deviation = 0.023 Å). In the crystal, molecules are linked via intermolecular N—H⋯N hydrogen bonds into a two-dimensional network parallel to (100).
Gut Flora in the Development and Progression of Nonalcoholic Fatty Liver Disease

Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in the United States. There is an increased prevalence noted among individuals with morbid obesity and type 2 diabetes. The prevalence of NAFLD is expected to continue to rise given the current global obesity epidemic. The pathogenesis of NAFLD is not clearly understood, but there is emerging evidence to suggest that the gut microbiota plays an important role. The gut microbiota is involved in dietary energy extraction, bile acid metabolism, endogenous alcohol production, choline metabolism, modulation of the host’s immune system and alteration of intestinal permeability. This review focuses on the potential pathways through which the gut microbiota is linked to the development and progression of NAFLD. Figure 1 is our proposed schematic representation of the role of the gut microbiota in NAFLD.
1-Dichloroacetyl-t-3,t-5-dimethyl-r-2,c-6-diphenylpiperidin-4-one

In the title compound, C21H21Cl2NO2, the piperidine ring adopts a distorted boat conformation. The phenyl rings substituted at the 2- and 6-positions of the piperidine ring subtend angles of 87.9 (7) and 70.8 (9)°, respectively, with the best plane through the piperidine ring. In the crystal, molecules are connected by C—H⋯O and C—H⋯Cl interactions into layers in the ab plane.
ABO BLOOD GROUPS IN CORRELATION WITH HYPERLIPIDEMIA, DIABETES MELLITUS TYPE II, AND ESSENTIAL HYPERTENSION

Objectives: There are associations between ABO blood groups and systemic diseases. So we aim to explore any associations among ABO blood group with hyperlipidemia; diabetes mellitus (DM) type II, and essential hypertension. Methods: A total of 800 subjects were recruited. Patients groups were subdivided into hyperlipidemia group (n=100), DM type II group (n=160), and hypertension group (n=166). Fasting blood sample was collected and plasma samples used for measuring of 2, 3-dinor-6-keto-prostaglandinF 1α (PGF1α), 11-dehydro-thromboxane (TX) B 2 , insulin, triglycerides (TGs), total cholesterol (Tc), high-density lipoprotein cholesterol (HDL-C), prothrombin time (PT), activated partial PT (aPPT), blood group type, random blood glucose level, and body mass index (BMI) were also determined. Results: Blood Group A demonstrates a significant elevation in insulin, random blood sugar (RBS), Tc, TGs, and low-density lipoprotein (LDL)/HDL ratio and shows a significant decrease in prostacyclin. Blood group B demonstrates a significant elevation in TXB , Tc, TGs, and LDL/HDL ratio and shows a significant decrease in PT. Blood group AB demonstrates a significant elevation in PT, and prostacyclin and shows a significant decrease in insulin, RBS, Tc, TGs, and LDL/HDL. Blood group O demonstrates a significant elevation in PT, and prostacyclin and shows a significant decrease in TXB2, Tc, TGs, and LDL/HDL ratio. 2 Conclusions: Blood group AB is protective against hyperlipidemia, diabetes, thrombosis, and hypertension, blood group O is protective against cardiovascular diseases while blood group B followed by A are risk factors for hypertension and blood group A is a risk factor for diabetes. These findings are establishing the ethnic-dependent correlation of ABO groups and studied diseases. Keywords: Hyperlipidemia, DM type II, Hypertension, Thrombosis, ABO blood groups.
2-[6-(4-Chlorophenyl)imidazo[2,1-b][1,3]thiazol-2-yl]-N′-[(E)-4-methoxybenzylidene]acetohydrazide

In the imidazo[2,1-b][1,3]thiazole group of the title compound, C21H17ClN4O2S, the dihedral angle between the thiazole and imidazole rings is 1.9 (2)°. The mean plane of this group makes dihedral angles of 5.5 (2) and 39.9 (2)° with the benzene rings of the chlorophenyl and methoxyphenyl groups, respectively. The dihedral angle between these two benzene rings is 34.4 (2)°. In the crystal, molecules are connected to each other by intermolecular N—H⋯O hydrogen bonds along the b axis, generating a C(4) chain. Weak C—H⋯π interactions also occur.
4-Chloro-2-methyl-N-(4-methylphenyl)benzenesulfonamide

The asymmetric unit of the title compound, C14H14ClNO2S, contains two independent molecules. The torsion angles of the C—SO2—NH—C segments in the two molecules are −76.5 (5) and −48.3 (4)°. The two aromatic rings are tilted relative to each other by 76.6 (2)° in one molecule and 70.7 (2)° in the other. In the crystal structure, intermolecular N—H⋯O hydrogen bonds link the molecules into centrosymmetric dimers.
2-Amino-4-(4-fluorophenyl)-6-methoxy-4H-benzo[h]chromene-3-carbonitrile

In the title molecule, C21H15FN2O2, the dihedral angle between the fluoro-substituted benzene ring and the mean plane of the 4H-benzo[h]chromene ring system [maximum deviation = 0.109 (2) Å] is 83.35 (7)°. The pyran ring adopts a slight sofa conformation with the tertiary C(H) atom forming the flap. The methoxy group is slightly twisted from the attached benzene ring of the 4H-benzo[h]chromene moiety [C—O—C—C = −4.3 (3)°]. In the crystal, molecules are linked by intermolecular N—H⋯N hydrogen bonds into infinite wave-like chains along the b axis. The crystal packing is further stabilized by π–π interactions [centroid–centroid distance = 3.7713 (9) Å].
N‐Benzoyl‐N,N′‐dicyclo­hexyl­urea

The title compound, C20H28N2O2, and N,N′-dicyclo­hexyl-N-(2-pyrazino­yl)urea are isostructural. Mol­ecules are linked into chains through (amide)N—H⋯O=C(amide) inter­molecular hydrogen bonds.
Assessment and Treatment of Impaired Insulin- Secretion and Action in Type 2 Diabetes

Type 2 diabetes (T2D) is a disease characterised by varying degrees of defect in insulin secretion and insulin sensitivity and associated with increased morbidity and mortality. Optimal glycaemic control reduces the progression of diabetic complications. Over time, there is a steady deterioration of glycaemic control that raises the need for effective therapy targeted at the underlying defects in order to achieve treatment goals. The methods available for assessment of insulin secretion and insulin sensitivity have not been suitable for use in clinical practice. The introduction of thiazolidinediones (TZDs) targeting the insulin resistance component of T2D has been promising but accompanied with some adverse effects, mainly fluid retention and heart failure. In this thesis, a simple method for independent measurement of β-cell function and insulin sensitivity at the same time (combined glucagon-insulin tolerance test, GITT) has been developed (Paper I). We also evaluated the effect of a TZD (pioglitazone) and a long-acting insulin (glargine) as add-on in the treatment of patients with T2D, not achieving glycaemic goals when treated with classic anti-diabetic agents on glycaemic control, insulin sensitivity, β-cell function and markers of increased cardiovascular load (Papers II &IV). We also investigated the effect of pioglitazone on eye protrusion (Paper III). GITT showed good reproducibility and the index of insulin sensitivity derived from the GITT showed good correlation with the M-value from the euglycaemic clamp. The test also showed good discriminating capacity between individuals with varying degrees of glucose tolerance (Paper I). Both pioglitazone and insulin glargine were effective in reducing HbA1c levels in combination with other oral glucose lowering agents but pioglitazone caused fluid retention and increased levels of natriuretic peptides suggesting increased cardiac load (Papers II & IV). While pioglitazone improved insulin sensitivity and lipids, insulin glargine resulted in improved β-cell function (Paper IV). Pioglitazone also caused an increase in eye protrusion in a subgroup of patients, probably by causing an increase in retrobulbar adipogenesis (Paper III). Taken together, these results can hopefully help clinicians in the choice of novel add-on treatment and in monitoring of untoward side effects. GITT seems to be a promising tool for assessing insulin secretion and action in clinical practice. (Less)
4-Ethyl-3-(2-thienylmethyl)-Δ2-1,2,4-triazoline-5-thione

The title compound, C9H11N3S2, exists in the thione form in the crystal structure. The central triazole ring is almost perpendicular to the thiophene ring which is disordered over two orientations [dihedral angles of 88.5 (7) and 85.7 (8)° for the two orientations]. The crystal structure is stabilized by strong intermolecular N—H⋯S hydrogen bonds, forming centrosymmetric dimers, and by some weak C—H⋯S interactions.
fac-Tri­carbonyl­chloro(1,10-phenanthroline)­rhenium(I)

The title compound, [Re(C12H8N2)(CO)3Cl], contains isolated molecular units. Rhenium(I) is six-coordinated by the two N atoms of 1,10-phenanthroline, three carbonyls and one chloride anion. The coordination sphere is a distorted octahedron, with the chloride anion trans to one of the carbonyls. There is a significant trans influence, which lengthens one of the Re—C bonds by ca. 0.05 A. The bidentate 1,10-phenanthroline deviates slightly from planarity, with a dihedral angle between its two heterocyclic rings of 5.5 (3)°, and is folded away from the chloride anion. The Re(I) atom lies 0.192 (3) A from the least-squares plane of 1,10-phenanthroline. There are no π ring interactions between adjacent 1,10-phenanthroline rings.
9-(2-Hydroxy-4,4-dimethyl-6-oxocyclohex-1-en-1-yl)-3,3-dimethyl-2,3,4,9-tetrahydro-1H-xanthen-1-one

The cyclohexene ring that constitutes a part of the tetrahydroxanthene fused-ring system of the title compound, C23H26O4, adopts a flattened half-chair conformation that approximates an envelope conformation (in which the methylene C atom bearing the two methyl substituents represents the flap) as five of the six atoms lie approximately on a plane (r.m.s. deviation = 0.020 Å). The mean plane of the cyclohexene ring with the hydroxy substituent is approximately perpendicular to the mean plane of the tetrahydroxanthene system. In the crystal, adjacent molecules are linked by O—H⋯Ocarbonyl hydrogen bonds into a chain running along the b axis.
1,1′-[Imidazolidine-1,3-diylbis(methylene)]bis(1H-benzotriazole)

In the title compound, C17H18N8, the imidazolidine ring adopts an envelope conformation with the substituents at the N atoms in trans positions with respect to the central ring. The dihedral angle between the two benzotriazole rings is 71.65 (10)°. In the crystal, non-classical C—H⋯N interactions link the molecules into helical chains along the b axis. The crystal packing is further stabilized by weak C—H⋯π interactions.