Miracle-dz/UniFAR-FTUs huggingface dataset:
Spage2vec: Unsupervised detection of spatial gene expression constellations

Investigation of spatial cellular composition of tissue architectures revealed by multiplexed in situ RNA detection often rely on inaccurate cell segmentation or prior biological knowledge from complementary single cell sequencing experiments. Here we present spage2vec, an unsupervised segmentation free approach for decrypting the spatial transcriptomic heterogeneity of complex tissues at subcellular resolution. Spage2vec represents the spatial transcriptomic landscape of tissue samples as a spatial functional network and leverages a powerful machine learning graph representation technique to create a lower dimensional representation of local spatial gene expression. We apply spage2vec to mouse brain data from three different in situ transcriptomic assays, showing that learned representations encode meaningful biological spatial information of re-occuring gene constellations involved in cellular and subcellular processes.
Tourism Experience Comparisons between China and Thailand: Empirical Evidence from Young Generation Chinese Respondents

The goal of this research is to study the satisfaction of traveling experienced between time in China and Thailand from the full-time bachelor degree Chinese students by using the normality and nonparametric 1 sample sign test. This study, therefore, examines young generation, Chinese respondents, regarding their experiences of traveling in Thailand to gain a better understanding of Chinese tourist behavior, and identify motivational factors that significantly influence their satisfaction. This research has compared and measured customer satisfaction for both experience in China against experience in Thailand in six variables namely Cost of traveling, Weather, Taste of local food, Interesting places, long-distance public transportation and Quality of life. To collect the relevant quantitative and qualitative data, questionnaires were given to the respondents with Chinese language translation. The findings show that Chinese students are highly satisfied with time in Thailand because of favorable weather, the taste of local food, interesting places, and better quality of life. However, the costs of traveling and long-distance public transportation for Thailand are doubtful in Chinese students perception.
Simultaneous estimation of serum and cerebrospinal fluid adenosine deaminase level to differentiate tuberculous and non-tuberculous meningitis

Introduction: Studies have shown the role of cerebrospinal fluid (CSF) adenosine deaminase (ADA) level but simultaneously estimation of serum and CSF-ADA to diagnose tuberculous meningitis (TBM) has been assessed rarely. Therefore, we conducted this study to assess the us efulness of serum and CSF-ADA in diagnosing TBM and to differentiate it with non-tuberculous meningitis in children. Material & Methods: A prospective, case-control study was conducted in tertiary care institution of central I ndia over one year. Children hospitalised with susp ected meningitis were recruited and serum and CSF-ADA levels were estimated after dividing them into TBM and non-tuberculous meningitis. Results: Out of 78 recruited cases, 36 had TBM while 42 had non-tuberculous etiology. 32 of 36 TBM cases had CSF- ADA above cut-off value (10U/L) while only 3 out of 42 controls had levels above this. Serum ADA above cut-off (60U/L) was seen in 13 TBM and 2 non-TBM cases. Mean CSF-ADA in cases (18.68±6.21 U/L) was significantly higher than in controls (5.98±2.75 U/L) (p 10U/L showed 92.86% sensitivity and 88.89% specificity (area under ROC curve - 0. 9742) in differentiating tuberculous from non-tuberculous me ningitis; it also has 91.43% positive predictive va lue and 90.70% negative predictive value. Serum ADA >60IU/L has shown sensitivity of 95.24% with poor specificity of 33.33%. Conclusion: CSF-ADA estimation is of considerable value to dia gnose TBM and to differentiate it from non-tubercul ous meningitis but simultaneous estimation of CSF and s erum ADA has no additional benefit.
Effect of Site Specific Nutrient Management on Yield and Quality of Soybean [Glycine max (L.)] in Soybean in Vertisols

Soybean is an oilseed as well as pulses crop having excellent nutritional quality, to contributes the highest world oil production. Phosphorus, an important constituent of biochemical products in plant itself; plays a key role in balance nutrition of the soybean and affect its productivity. Balanced fertilization is the key to achieve higher productivity and nutrient use efficiency and balanced nutrition with NPK proved beneficial in all the oilseed crops both under rainfed and irrigated conditions. Further, nutrients like S, Ca, Cu and B are also needed for higher yields (Ghosh et al., 2002). SSNM strategies that include site and specific knowledge of crop nutrient requirement and indigenous nutrient supplies is useful for improving nutrient use efficiency and crop productivity as well as for maintaining soil health in semi arid eco regions. Right fertilizer management must support stake holder’s to contribute goals of performance. The farmers are best managers International Journal of Current Microbiology and Applied Sciences ISSN: 2319-7706 Volume 8 Number 11 (2019) Journal homepage: http://www.ijcmas. com
OPTIMIZATION OF THE COLLOIDAL PROPERTIES OF DIFFERENT VESICULAR SYSTEMS AIMING TO ENCAPSULATE (-)-EPIGALLOCATECHIN-3-GALLATE

The objective of this study was to optimize different vesicular systems containing (-)-epigallocatechin-3-gallate (EGCG); namely penetration enhancer-containing vesicles, ethosomes, transfersomes and transethosomes in order to maximize its therapeutic efficacy. Empty vesicles were prepared using Epikuron 200 and permeation enhancers including polyethylene glycol 400, ethanol, Tween 80 and ethanol/Tween 80 mixture. The colloidal properties of the prepared vesicles were evaluated. Empty vesicles displaying optimum properties were selected for drug loading in order to evaluate their entrapment efficiency. Further optimization of the properties of the drug-loaded vesicles was performed through modification of the conditions of the encapsulation process. Results revealed that decreasing the amount of Epikuron 200 with increasing the percentage of the enhancer reduced the vesicles size and polydispersity index. Loading of vesicles with EGCG markedly increased their size and surface charge. Doubling the volume of hydration medium significantly reduced the size of drug-loaded vesicles while preserving the optimum encapsulation efficiency. Hence, it can be concluded that proper optimization of vesicular properties is necessary in order to maximize the entrapment and consequently the topical therapeutic potential of EGCG.
Gall bladder specimen following cholecystectomy: a resource

Background: Gallbladder stones are very common and cholecystectomy is the most commonly performed surgery globally. Gallbladder stones have been reported to be the leading cause of cholecystectomies worldwide. Other mechanisms have also been known to constitute for cholecystectomy, but the evidence is still weak with the exact mechanism unknown. The present study thus aims to assess the importance of routine histopathology of the gall blabber following cholecystectomy. Methods: The study is a retrospective one that employs the use of patient records to achieve the objective. Results: The findings of the study depict a significant association between the findings of the histopathology, ultrasound and clinical features. Conclusions: The researcher presents the relevance of histopathology with respect to ultrasound and clinical presentation of the patient, thereby stating the need for a routine gall bladder specimen following cholecystectomy.
Embedded system for upper-limb exoskeleton based on electromyography control

A major problem in an exoskeleton based on electromyography (EMG) control with pattern recognition-based is the need for more time to train and to calibrate the system in order able to adapt for different subjects and variable. Unfortunately, the implementation of the joint prediction on an embedded system for the exoskeleton based on the EMG control with non-pattern recognition-based is very rare. Therefore, this study presents an implementation of elbow-joint angle prediction on an embedded system to control an upper limb exoskeleton based on the EMG signal. The architecture of the system consisted of a bio-amplifier, an embedded ARMSTM32F429 microcontroller, and an exoskeleton unit driven by a servo motor. The elbow joint angle was predicted based on the EMG signal that is generated from biceps. The predicted angle was obtained by extracting the EMG signal using a zero-crossing feature and filtering the EMG feature using a Butterworth low pass filter. This study found that the range of root mean square error and correlation coefficients are 8°-16° and 0.94-0.99, respectively which suggest that the predicted angle is close to the desired angle and there is a high relationship between the predicted angle and the desired angle.
THE EFFECT OF LEADERSHIP AND ORGANIZATION COMMITMENTS TO PERFORMANCE OF CONTRACT EMPLOYEES WITH ORGANIZATIONAL CITIZENSHIP BEHAVIOUR (OCB) AS A MEDIATION VARIABLE

Extra role behavior or known as Organizational Citizenship Behavior (OCB) is very important to have because it also contributes positively to organizational performance. Contract employees are required to have good performance and be able to meet the hopes and desires of all parties, especially the community who have chosen and trusted a health care center. This study aims to examine the effect of leadership and organizational commitment on the performance of contract employees with extra role behavior as a mediating variable. This research was conducted at the Puskesmas Abiansemal I and II with a population of 79 people. All data obtained from questionnaire distribution is feasible to use and then analyzed using PLS (Partial Least Square). The results showed that leadership had no significant effect on the performance of contract employees with a correlation coefficient of 0.046, t-statistics 0.337 (t> 1.96). Organizational commitment has a significant effect on employee performance. Leadership has a significant effect on Organizational Citizenship Behavior (OCB). Organizational commitment has a significant effect on Organizational Citizenship Behavior (OCB). Organizational Citizenship Behavior (OCB) is able to fully mediate the indirect influence of leadership on employee performance. Organizational Citizenship Behavior (OCB) is also able to mediate the indirect effect of the effect of organizational commitment on performance. The results of this study can be applied in the Abiansemal I and II Puskesmas because with an increase in leadership, it can improve the Organizational Citizenship Behavior (OCB) of contract employees who will indirectly improve the performance of contract employees. As well as improving other things such as organizational commitment, OCB which will improve the performance of contract employees.
Medical Physiology Principles For Clinical Medicine

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Lexical Processing of English Derived Words by Korean EFL Learners and NSE

Debate has continued about how L1 speakers process morphologically complex words. Consensus has been divided between single- and dual-route processing models. We conducted lexical decision experiments with a wide variety of English derived words to investigate how Korean EFL learners and L1 English speakers access complex words. First, we show that English prefixed or suffixed words are processed with greater cost than simplex words for both English L1 speakers and EFL learners. Second, suffixed words are processed with faster response times and higher accuracy than prefixed words. Third, complex words are accessed differently in terms of affixal salience according to the individual affixes that belong to the same morphological classes. Finally, the homophony of affixes with dual membership induces Korean EFL learners, not English L1 speakers to process complex words with more difficulty than those with single-membership affixes. These results suggest that derived words are processed via morphological decomposition into stems and affixes whereas simplex words are directly accessed as whole word units, supporting the dual-route processing models. Additionally, this study implies that prefixes are more likely to be parsed from the bases than suffixes. Furthermore, it is suggested that the processing efficiency of derivational words varies according to each affix type, which complements the formal structural theory of lexical morphology. Finally, it is indicated that the confusability of affixes with dual membership hinders the processing of the derivational words.
Perceived Interpersonal Influences and College-Major Nontraditionality as Predictors of Women’s Leadership Aspirations

In this study, we examined the degree to which two forms of perceived interpersonal influence relate to college women’s plans to become leaders in their career fields. We also tested whether those associations vary as a function of the nontraditionality of the women’s majors (as indexed by the percentage of male students in their majors). The responses of 673 female undergraduate students to an online survey revealed that perceived support/guidance for career decision-making and perceived inspiration from career role models both had unique and positive associations with leadership aspirations, but those associations did not differ based on major nontraditionality. We discuss implications for career interventions designed to facilitate college women’s leadership aspirations and identify future research directions.
Manure Utilization from Cows, Goats, and Chickens as Compost, Biochar, and Poschar in Increasing the Red Chili Yield

This study aimed to determine the characteristics of biochar, compost, and poschar from livestock manure waste and its effect on the yield of red chili plants. Randomized Block Design (RBD) with nested patterns was used in this study. The treatment composition consisted of 9 types of fertilizer (cow compost, goat compost, chicken compost, beef biochar, goat biochar, chicken biochar, beef poschar, goat poschar, and chicken poschar), and 3 levels of fertilizer doses (5, 10, and 15-ton ha -1 ) and one control treatment. The results showed that the type of fertilizer treatment did not significantly influence all observed variables, except the maximum plant height and fresh weight of shoot had a very significant effect. While the dose of fertilizer did not have a significant effect on most of the variables observed except for the height of the chili plant, the weight of the fresh stem and leaves, and the weight of the fresh chili harvested. In various types of fertilizer treatments, the maximum plant height obtained in chicken biochar (111.53 cm), which shows a slight difference when it was compared with the lowest plant height of 99.58 cm in biochar goat. The treatment of compost, biochar, and poschar sourced from 15 tons ha -1 chicken manure achieved the highest yields of fresh weight of chili harvested respectively 266.06 g, 270.95 g, and 280.05 g which were significantly increased 39.16%, 41.72%, and 46.48% compared with control (without treatments).
Enhancing high throughput sequencing unveils changes in bacterial communities during ready-to-eat lettuce spoilage

Purpose: Spoilage flora is critical in vegetal ready to eat (RTE) product shelf-life and selecting efficient spoilage control technologies depends on the microorganisms present. This manuscript describes the evolution of the bacteriome of Batavia RTE lettuce, from fresh lettuce up to completely spoiled (day 14) and correlate these results with the sensorial characteristics. Research Method: The microbiome of vegetal RTE were examined using culture-dependent and culture-independent (16S rRNA metabarcoding) methods. Culture-dependent methods were related with the metagenomic results and sensory analysis to describe the evolution during spoilage and shelf-life. Findings: Our results demonstrated that the RTE lettuce bacteriome during spoilage is dominated by Gram-negative bacteria, mainly Flavobacterium and Pseudomonas. A bacterial population of 22 operational taxonomic units (OTUs) represent up to 96% of total bacterial reads and is maintained during the spoilage, representing the bacterial core of RTE lettuce. A high correlation was detected between culture-independent and culture-dependent results, both in general and selective culture media. Sensorial analysis of lettuce demonstrated that "odor" was the key parameter to determine the sensorial spoilage time and is related to total microbial load and to high concentrations of spoilage-related bacterial genera. Limitations: Hereby presented results are limited by the lettuce variety and by the storage conditions (MAP, 6°C, up to 14 days). Originality/Value: This paper describes an overview of the microbial and sensory evolution during spoilage of Batavia lettuce under MAP. A combination of culture-dependent and independent methods and sensorial analysis were used up to 14 days of storage.
Post-extrusion heating in 3-D printing

Stresses result when polymer feed stock is extruded through the nozzle of a 3-D printer, causing undesirable surface roughness called “sharkskin”, which hinders effective bonding to the substrate. A promising method to remove the sharkskin is to reheat the polymer after extrusion. However, questions remain about the appropriate design parameters to guarantee success. A mathematical model is presented for this system, and both amorphous and crystalline polymers are examined. The former is a heat transfer problem; the latter a Stefan problem. Several effectiveness conditions are considered, including exit temperature and a duration condition related to the polymer relaxation time. Our results provide guidance on designing effective post-extrusion heaters.
Counterion coupled (COCO) gemini surfactant capped Ag/Au alloy and Ag@Au core–shell nanoparticles for cancer therapy

Hybrid silver (Ag)–gold (Au) nanoparticles (NPs) with different sizes and compositions were synthesized. Ag/Au alloy and Ag@Au core–shell type NPs were prepared from Ag and Au with various ratios using the COCO gemini surfactant, 1,6-bis (N,N-hexadecyldimethylammonium) adipate (COCOGS), 16-6-16 as a stabilizer. The formation of the Ag/Au alloy and Ag@Au core–shell was confirmed by UV-visible absorption spectroscopy, high-resolution transmission electron microscopy (HRTEM), energy-dispersive X-ray spectroscopy (EDX) and selected area electron diffraction (SAED) patterns. Depending on the composition of the Ag/Au alloy NPs, the λmax values varied from 408 nm to 525 nm. FTIR measurements were used to evaluate the adsorption of the COCO gemini surfactant (16-6-16) on the Ag/Au alloy and Ag@Au core–shell surface. In this present work, we study how to achieve the stability and activity of the COCO gemini surfactant (16-6-16) capped Ag/Au alloy and Ag@Au core–shell NPs for developing novel anti-cancer agents by evaluating their potentials in the Hep-2 cell line model. Thus the developed core–shell NPs were possibly involved in inducing cytotoxicity followed by inhibition of cell proliferation to the cancer cells with apoptosis induction. The developed core–shell NPs might serve as highly applicable agents in the development of next-generation cancer chemotherapeutic agents.
SUPERPOSITIONED STATIONARY COUNT TIME SERIES

Abstract This paper probabilistically explores a class of stationary count time series models built by superpositioning (or otherwise combining) independent copies of a binary stationary sequence of zeroes and ones. Superpositioning methods have proven useful in devising stationary count time series having prespecified marginal distributions. Here, basic properties of this model class are established and the idea is further developed. Specifically, stationary series with binomial, Poisson, negative binomial, discrete uniform, and multinomial marginal distributions are constructed; other marginal distributions are possible. Our primary goal is to derive the autocovariance function of the resulting series.
AACE/ACE Disease State Clinical Review

Objective: To review the current literature regarding the prevalence of macroprolactin (macroPRL) in hyperp-rolactinemic patients and determine recommendations for testing. Methods: An electronic United States National Library of Medicine PubMed search (through October, 2014) was conducted for search term “macroprolactin. ” Only English-language articles were considered. Results: MacroPRL is an under-recognized cause of elevated prolactin (PRL) and is present in approximately 4% to 40% of hyperprolactinemic patients depending on the referral population. Clinical findings which could be due to hyperprolactinemia are the impetus for testing for PRL. Because of this there is significant overlap in the clinical presentation of patients with true hyperprolactinemia and those with macroPRL, differentiation cannot always be made on the basis of symptoms. A lack of recognition of the presence of macroPRL can lead to unnecessary laboratory investigations, imaging, and pharmacologic or surgical treatment. Conclusion: Until there is a commercially available PRL assay that is not subject to interference by macroPRL, clinicians should consider the possibility of macroPRL, especially if the clinical presentation, imaging findings, and/or response to therapy reveal inconsistencies. (Endocr Pract. 2015;21:1427-1435) Abbreviations:
Diagnostic Utility of Reduced Radiation Dose Non-Contrast-Enhanced CT with Iterative Reconstruction for Screening in High-Risk Individuals with Pancreatic Cancer: An Anthropomorphic Phantom Study

Background: Previous studies showed that the dilated main pancreatic duct (MPD) and pancreatic cysts were the important predictors of the subsequent development of pancreatic cancer. The purpose of this study was to reveal the utility of non-contrast reduced radiation dose CT with iterative reconstruction for screening in high risk pancreatic cancer individuals by assessing the dilated MPD and cysts by using abdominal phantoms. Materials and methods: Two phantoms with normal and abnormal pancreas with dilated MPD (5 mm) and cysts (5 mm, 10 mm and 15 mm) were constructed. Each phantom was scanned by ten images using following three protocols: 120 kVp and 120mA with filtered back projection (FBP) algorithm (120 kVp-FBP), 80 kVp and 168mA with FBP algorithm (80 kVp-FBP), and 80 kVp and 168mA with sinogram affirmed iterative reconstruction (SAFIRE) (80 kVp-SAFIRE). The image noise and contrast-to-noise ratio (CNR) of the 15mm cyst were assessed. The radiation dose was assessed with the volume CT dose index (CTDIvol). Two radiologists scored the image quality and conspicuity of the dilated MPD and cysts. Results: Mean image noise significantly decreased from 80 kVp-FBP images to 80 kVp-SAFIRE and 120 kVp-FBP images (p < 0.001). The CNR significantly increased from 80 kVp-FBP images to 120 kVp-FBP and 80 kVp-SAFIRE images (p < 0.05). Image quality was significantly lower in the 80 kVp-FBP images than in 120 kVp-FBP and 80 kVp- SAFIRE images in both readers (p < 0.05). The conspicuity point for the dilated MPD and three cysts was higher in 80 kVp-SAFIRE images than in 80 kVp-FBP and 120 kVp-FBP images. CTDIvol was reduced by 60 % at 80 kVp protocol. Conclusion: Non-contrast 80 kVp-SAFIRE CT protocol allowed for higher conspicuity of dilated MPD and cysts at a reduced radiation dose compared with 120 kVp-FBP protocols.