Miracle-dz/UniFAR-FTUs huggingface dataset:
A new manganese-hyperaccumulator: Polygonum hydropiper L

It is main groundwork and the first step of phytoextraction of its commercial application on a large scale to screen out a series of ideal hyperaccumulators that can effectively remedy contaminated soil by heavy metals,which is also difficult point and front field of contaminated environment phytoremediation. Polygonum hydropiper L. , potential new manganese (Mn)-hyperaccumulator, was firstly found and testified both in field survey and simulated experiment in lab. The results showed that the content of Mn was 2 000 mg·kg-1 in the mining area soil, the maximum Mn concentration in the leaves of Polygonum hydropiper L. could reach as high as 3 675.89 mg·kg-1 and the transport coefficient of Mn was 1.37. The further aquicultural experiment indi- cated that the Mn concentration in the leaves of Polygonum hydropiper L. exceeded 10 000 mg·kg-1, which was a critical content standard of Mn Hyperaccumulator, when the Mn concentration was 5 000 μmol·L-1 in solution. The accumulation coefficient of Mn in shoots was higher than 19.41, and its transport coefficient reached 1.05. At the same time, the growth of Polygonum hydropiper L. did not appear to abnormity comparing with control. The maximum Mn concentrations in the leaves、roots and stems of Polygonum hydropiper L. were 24 447.17 mg·kg-1, 11 574.47 mg·kg-1 and 10 343.52 mg·kg-1, respectively, when the Mn concentration was 15 000 μmol·L-1 in solution. Therefore this species may provide a potential new plant to for use in the phytoremediation of manga- nese-contaminated soils and water.
Testing for Homogeneity in Panel Data Models with Discrete Unobserved Heterogeneity

It has been well known that classic Wilks’ Theorem for the asymptotic distribution of LRT statistics cannot be usually applied in finite mixture models, due to the presence of nuisance parameters that are not identified under the null hypothesis and mixing parameters on the boundary. In this paper, we derive the asymptotic distribution of likelihood ratio test (LRT) statistics for testing homogeneity in panel data models with normal mixture under difference in location. We show how reparametrization technique introduced in Kasahara and Shimotsu (2012) (KS12, hereafter) can be used to study its asymptotic behaviours under the framework of Andrews (1999, 2001) (A99 and A01, hereafter) to eliminate these issues.
Dengue Hemorrhagic Fever and Its Correlation with The Weather Factor In Bandar Lampung City

Dengue Hemorrhagic Fever (DHF) is the most serious vector in Bandar Lampung. Dengue virus and its vector Aedes Aegypti to weather changes, especially rainfall, temperature and humidity. This research objective was to determine the correlation between weather factors and dengue cases using the period 2009-2018. Data obtained from reports on the number of monthly cases of the in Health Office of Bandar Lampung City, and daily climate reports from the Meteorology, Climatology and Geophysics Agency, which are converted into monthly averages. We found that the highest DHF cases were in January, February and March. Rainfall has a positive correlation with the number of dengue cases in 2011 (p-value = 0.012) and 2015 (p-value = 0.020). Each year, the rainy period precedes the start of the increase in dengue cases. Temperature has a negative correlation in 2014 (p-value = 0.036). Humidity has a positive correlation in 2014 (p-value = 0.024) and 2015 (p-value = 0.018). Rainfall has the greatest influence in relation to DHF cases in Bandar Lampung City (36.9%). These findings provide empirical evidence regarding the correlation between weather factors and DHF transmission, and are expected to provide a scientific basis for the prevention and This open access article is under the CC–BY-SA license.
How Do Biodiversity and Culture Intersect?

There is a common recognition around the world that the diversity of life involves both the living forms (biological diversity) and the world views and cosmologies of what life means (cultural diversity) (Posey, 1999; Berkes et al., 2000; Maffi, 2001; Harmon, 2002). The importance of this diversity is increasingly recognised, as is knowledge of this diversity, even in industrialised societies where it is often heavily depleted (e.g. Mabey, 1997; Cocker & Mabey, 2005), and in urban areas where people are often disconnected from their traditional natural resource base (Cocks & Dold 2000, 2004, 2006; Wiersum & Shackleton 2006). However the division commonly made between nature and culture is not universal, and, in many cases, is a product of modern industrialised thought shaped by our need to control, or ‘manage’ nature (Berkes, 2008).
Phytotoxic effects of mercury on seed germination and seedling growth of Albizia lebbeck (L.) Benth. (Leguminosae)

A study was conducted to determine the phytotoxic effect of mercury on seed germination and seedling growth of an important arid legume tree Albizia lebbeck. The seeds germination and seedling growth performance of A. lebbeck responded differently to mercuric chloride treatment (1 mM, 3 mM, 5 mM and 7 mM) as compared to control. Seed germination of A. lebbeck was significantly (p < 0.05) affected by mercury treatment at 1 mM. Root growth of A. lebbeck was not significantly affected by mercury treatment at 1 mM, and 3 mM. Shoot and root length of A. lebbeck were significantly (p < 0.05) affected by 5 mM concentration of mercury treatment. Increase in concentration of mercury treatment at 5 mM and 7 mM significantly (p < 0.05) reduced seedling dry weight of A. lebbeck. The treatment of mercury at 1 mM decreased high percentage of seed germination (22%), seedling length (10%), root length (21.85%) and seedling dry weight (9%). Highest decrease in seed germination (51%), seedling (34%), root length (48%) and seedling dry weight (41%) of A. lebbeck occurred at 7 mM mercury treatment. A. lebbeck showed high percentage of tolerance (78.14%) to mercury at 1 mM. However, 7 mM concentration of mercury produced lowest percentage of tolerance (51.65%) in A. lebbeck. The seed germination potential and seedling vigor index (SVI) clearly decreased with the higher level of mercury. Plantation of A. lebbeck in mercury-polluted area will help in reducing the burden of mercury pollution. A. lebbeck can serve better in coordinating in land management programs in metal contaminated areas. The identification of the toxic concentration of metals and tolerance indices of A. lebbeck would also be helpful for the establishment of air quality standard.
Detection of musically relevant regions in multiresolution time-frequency representations evaluated on piano recordings

This paper investigates possible estimators of musical information in subregions of a time-frequency representation of an audio signal, in the context of obtaining multiresolution time-frequency representations through iterative re-ﬁnements. An experiment was conducted comparing estimators extracted from STFT spectrograms of Disklavier performances to reference values extracted from the corresponding MIDI ﬁles. Different reference values were considered, capturing the presence of musical information in the time-frequency plane that are relevant to music information retrieval tasks such as automatic music transcription and timbre analysis. The impact of the size of the time-frequency subregions and initial resolution of the STFT were analyzed. The inﬂuence of the introduction of simple energy decay models in the reference values was also investigated. A second experiment was conducted evaluating chosen estimators as features in a predictive model for the binary detection of musically relevant regions of a time-frequency representation. Naive-Bayes models were trained using binary piano rolls (with and without harmonics) as ground truth. Results show that it is possible to detect musically relevant regions of a time-frequency representation with satisfactory results using Shannon and R´enyi entropies.
Cariprazine: Patients with Treatment-Resistant Schizophrenia

Abstract Schizophrenia is a chronic relapsing and remitting disorder associated with significant impairments in social and vocational functioning and a shortened lifespan, and it is a disabling psychiatric brain syndrome whose phenotype is characterized by three core symptom domains: positive symptoms, such as delusions and hallucinations, negative symptoms, which include lack of motivation and social withdrawal, and cognitive impairment. Moreover, patients with schizophrenia have severe problems with personal and social relations which affect their quality of life. Antipsychotic medications in conjunction with psychosocial interventions can help patients achieve recovery. Here are described three clinical cases of schizophrenic patients treated with cariprazine for inadequate response to a previous treatment. The purpose of this clinical series is to give useful information for the use of cariprazine in clinical practice.
3D Topology Optimization and Mesh Dependency for Redesigning Locking Compression Plates Aiming to Reduce Stress Shielding

Current fixation plates for bone fracture treatments are built with biocompatible metallic materials such as stainless steel, titanium, and its alloys (e.g., Ti6Al4V). The stiffness mismatch between the metallic material of the plate and the host bone leads to stress shielding phenomena, bone loss, and healing deficiency. This paper explores the use of three dimensional topology-optimization, based on compliance (i.e., strain energy) minimization, reshaping the design domain of three locking compression plates (four-screw holes, six-screw holes, and eight-screw holes), considering different volume reductions (25, 45, and 75%) and loading conditions (bending, compression, torsion, and combined loads). A finite-element study was also conducted to measure the stiffness of each optimized plate. Thirty-six designs were obtained. Results showed that for a critical value of volume reductions, which depend on the load condition and number of screws, it is possible to obtain designs with lower stiffness, thereby reducing the risk of stress shielding.
Two mitochondrial genomes of Taiwanese rhinoceros beetles, Oryctes rhinoceros and Eophileurus chinensis (Coleoptera: Scarabaeidae)

Abstract Two mitochondrial genomes of the dynastine beetles, Oryctes rhinoceros (Linnaeus, 1758) and Eophileurus chinensis (Faldermann, 1835), were assembled via high-throughput sequencing (HTS). Each of the mitogenomes has 37 genes, showing standard gene order and annotation as the other insects, except for the transfer genes, presenting tQ-tI-tM order. To examine their phylogenetic positions, 118 public mitogenomes of Scarabaeidae were used to infer a ML tree. Overall, our scarabaeid phylogeny reveals clear relationships with high nodal supports, and the two rhinoceros beetles are both grouped with the subfamily Dynastinae. The feeding habit of the two clades seems to represent coprophagous and phytophagous types. However, polyphyletic relationships were observed in the subfamily Melolothinae and in the tribes of Onthophagini and Oniticellini. Further systematic revision is needed.
Health informatics publication trends in Saudi Arabia: a bibliometric analysis over the last twenty-four years

Objective: Understanding health informatics (HI) publication trends in Saudi Arabia may serve as a framework for future research efforts and contribute toward meeting national “e-Health” goals. The authors’ intention was to understand the state of the HI field in Saudi Arabia by exploring publication trends and their alignment with national goals. Methods: A scoping review was performed to identify HI publications from Saudi Arabia in PubMed, Embase, and Web of Science. We analyzed publication trends based on topics, keywords, and how they align with the Ministry of Health's (MOH's) “digital health journey” framework. Results: The total number of publications included was 242. We found 1 (0.4%) publication in 1995–1999, 11 (4.5%) publications in 2000–2009, and 230 (95.0%) publications in 2010–2019. We categorized publications into 3 main HI fields and 4 subfields: 73.1% (n=177) of publications were in clinical informatics (85.1%, n=151 medical informatics; 5.6%, n=10 pharmacy informatics; 6.8%, n=12 nursing informatics; 2.3%, n=4 dental informatics); 22.3% (n=54) were in consumer health informatics; and 4.5% (n=11) were in public health informatics. The most common keyword was “medical informatics” (21.5%, n=52). MOH framework–based analysis showed that most publications were categorized as “digitally enabled care” and “digital health foundations. ” Conclusions: The years of 2000–2009 may be seen as an infancy stage of the HI field in Saudi Arabia. Exploring how the Saudi Arabian MOH's e-Health initiatives may influence research is valuable for advancing the field. Data exchange and interoperability, artificial intelligence, and intelligent health enterprises might be future research directions in Saudi Arabia.
Comprehensive Mechanism, Novel Markers and Multidisciplinary Treatment of Severe Acute Pancreatitis-Associated Cardiac Injury – A Narrative Review

Abstract Acute pancreatitis (AP) is one of the common acute abdominal inflammatory diseases in clinic with acute onset and rapid progress. About 20% of the patients will eventually develop into severe acute pancreatitis (SAP) characterized by a large number of inflammatory cells infiltration, gland flocculus flaky necrosis and hemorrhage, finally inducing systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction syndrome (MODS). Pancreatic enzyme activation, intestinal endotoxemia (IETM), cytokine activation, microcirculation disturbance, autonomic nerve dysfunction and autophagy dysregulation all play an essential role in the occurrence and progression of SAP. Organ dysfunction is the main cause of early death in SAP. Acute kidney injury (AKI) and acute lung injury (ALI) are common, while cardiac injury (CI) is not, but the case fatality risk is high. Many basic studies have observed obvious ultrastructure change of heart in SAP, including myocardial edema, cardiac hypertrophy, myocardial interstitial collagen deposition. Moreover, in clinical practice, patients with SAP often presented various abnormal electrocardiogram (ECG) and cardiac function. Cases complicated with acute myocardial infarction and pericardial tamponade have also been reported and even result in stress cardiomyopathy. Due to the molecular mechanisms underlying SAP-associated cardiac injury (SACI) remain poorly understood, and there is no complete, unified treatment and sovereign remedy at present, this article reviews reports referring to the pathogenesis, potential markers and treatment methods of SACI in recent years, in order to improve the understanding of cardiac injury in severe pancreatitis.
Tuberculosis in Migrants is Among the Challenges of Tuberculosis Control in High-Income Countries

Abstract The incidence of tuberculosis (TB) is high among migrants in high-income countries. The migration process could contribute to the high incidence of TB among them. Achieving TB elimination from these settings will be difficult unless countries address the burden of TB among migrants. The aim of this review was to describe the challenges of international migration on TB control in high-income, low TB incidence countries. Among migrants, there is a high prevalence of risk factors for TB, such as exposure to TB, HIV, malnutrition, substance use, delayed diagnosis, low education, poor health-seeking, the culture, stigma and marginalization. Discriminatory policies of TB care and social barriers such as language, cultural issues and unfriendly health services may also contribute to the high prevalence of TB among them. TB control among migrants in these settings is important as migrants are vulnerable to TB infection and disease, and implementing TB care among them is difficult; it is important to reduce the TB burden in migrants and the community at large and the high risk of multidrug-resistant TB (MDR-TB). TB elimination from high-income countries requires acquiring data and analyzing it to measure the burden, having migrant-sensitive health systems, having policy and legal frameworks and multi-country partnerships and conducting research.
Review of progresses on clinical applications of ion selective electrodes for electrolytic ion tests: from conventional ISEs to graphene-based ISEs

Abstract There exist several positively and negatively charged electrolytes or ions in human blood, urine, and other body fluids. Tests that measure the concentration of these ions in clinics are performed using a more affordable, portable, and disposable potentiometric sensing method with few sample volumes, which requires the use of ion-selective electrodes (ISEs) and reference electrodes. This review summarily descriptively presents progressive developments and applications of ion selective electrodes in medical laboratory electrolytic ion tests, from conventional ISEs, solid-contact ISEs, carbon nanotube based ISEs, to graphene-based ISEs.
Task force veterinary anatomy: joint efforts of the five German veterinary schools to ensure education during the COVID-19 pandemic

At the start of the COVID-pandemic in March 2020, the Institutes of Veterinary Anatomy of the five German educational institutions were confronted with the challenge of digitalising all lectures for the second and fourth semesters of veterinary students. After an online kick-off event and a preliminary status quo meeting, available digital teaching material was exchanged for students to stream from learning platforms. Lectures were either synchronized or made available as audio recordings and connotated slides on the learning platforms. Fortunately, digital microscopic slides had already been in use, which made it easy for students to access them. Dissection exercises mostly consisted of self-study, using instructive videos and interactive exercises. In the second half of the semester, four of the educational institutions were able to offer a restricted number of in-person gross anatomy classes under reinforced conditions. Success monitoring took place online through different formats, and partially on a voluntary basis, via the learning platforms. Although the past two semesters had to almost exclusively take place online due to the unprecedented circumstances, and joint efforts of the five veterinary institutions, there is a general consensus that the practical education in anatomy, histology and embryology is essential to veterinary students. In fact, it is the only way they can obtain the necessary skills to successfully complete the rest of their degree.
The Relevance of Small Airway Dysfunction in Asthma with Nocturnal Symptoms

Rationale Small airway dysfunction (SAD) is a frequent feature of asthma that has been linked to disease severity and poor symptom control. However, little is known about the role of SAD in nocturnal asthma. Objective To study the association between the severity of SAD and frequency of nocturnal symptoms compared to conventional lung function testing. Methods We assessed the frequency of self-reported nocturnal symptoms through the asthma control test. We studied the impact of nocturnal asthma using the Asthma Quality of Life Questionnaire (AQLQ) and the Multidimensional Fatigue Inventory (MFI-20). We assessed the lung function using spirometry, body plethysmography, impulse oscillometry, single and multiple inert gas washout and measured markers of T2-inflammation (blood and sputum eosinophils; fractional exhaled nitric oxide (FeNo)). We stratified the patients according to the presence and frequency of nocturnal asthma. Results A total of 166 asthma patients were enrolled in the analysis. Eighty-seven patients (52%) reported to have nocturnal symptoms at least once in the last four weeks. The odds ratio of nocturnal asthma correlated with the severity of all non-spirometric measures of SAD, yet neither with airflow obstruction (FEV1 and FEV/FVC) nor with large airway resistance (R20). Patients with frequent nocturnal asthma (n = 29) had a numerical increase of T2 markers and more severe SAD, as indicated by all non-spirometric measures of SAD (all p-values < 0.05), worse overall asthma control, increased fatigue and reduced quality of life (all p-values < 0.01) compared to patients with infrequent nocturnal asthma (n = 58) or patients without nocturnal asthma (n = 79). We identified 63 patients without airflow obstruction, nearly 43% of them (n = 27) had nocturnal asthma. In this subgroup, only markers of air trapping and ventilation heterogeneity were significantly elevated and correlated with the frequency of nocturnal symptoms: LCI (Spearman’s coefficient = −0.42, p < 0.001), RV% (−0.32, p = 0.02). Conclusion SAD is closely associated to asthma with nocturnal symptoms. Spirometry might underestimate the broad spectrum of distal lung function impairments in this population of patients.
Local Control of Primary Dural Central Nervous System Lymphoma Achieved With Radiotherapy

Primary central nervous system lymphomas (PCNSL) are extranodal non-Hodgkin's lymphomas (NHL) confined to the brain, leptomeninges, eyes, or spinal cord. Primary leptomeningeal lymphoma (PLML), without parenchymal involvement, synchronous cerebrospinal, or systemic disease is rare. The estimated incidence of PLML is 7% of all PCNSL, which in turn accounts for about 2% of all primary brain tumors and 0.8% of all lymphomas. The incidence of PCNSL in Western countries is approximately five cases per million inhabitants per year, and less than 5% of all primary tumors of the central nervous system (CNS), although it is worth mentioning that the incidence seems to be increasing. The largest series of cases reported in the medical literature collect information from no more than nine patients; in these series, the median age at diagnosis is 57 years; in general, all patients present with cerebrospinal fluid alteration, and the median overall survival rate is close to eight months. With our case series, we aim at sharing the experience of four patients diagnosed and treated at the National Cancer Institute between 2010 and 2020, establishing a correlation of the clinical, imaging, and histopathological presentation, the response to treatment based on radiotherapy and chemotherapy, and the clinical outcomes reported in the medical records.