Miracle-dz/UniFAR-FTUs huggingface dataset:
High BMI and Insulin Resistance Are Risk Factors for Spontaneous Abortion in Patients With Polycystic Ovary Syndrome Undergoing Assisted Reproductive Treatment: A Systematic Review and Meta-Analysis

Background The risk of spontaneous abortion in patients with polycystic ovary syndrome (PCOS) undergoing assisted reproductive treatment (ART) is higher than that in patients without PCOS, however, no definitive risk factors have been confirmed to associate with the high spontaneous abortion rate in PCOS patients undergoing ART. This study was performed to assess the impact of relevant risk factors on spontaneous abortion in patients with PCOS. Clinical questions were formulated and organized according to the PICOS principle. Methods A systematic review and meta-analysis were conducted on all published studies on PCOS and spontaneous abortion in Embase, PubMed, Web of Science and Cochrane Library. Related risk factors included body mass index (BMI), age, insulin resistance (IR), hyperandrogenism, and chromosome aberrations. All patients were diagnosed as PCOS using the Rotterdam criteria. The primary endpoint was miscarriage and live birth rate. Fixed-effect models were used to analyze homogeneous data, and subgroup and sensitivity analyses were performed on heterogeneous data. The source of heterogeneity was evaluated, and the random effect model was used to summarize the heterogeneity. Results Among 1836 retrieved articles, 22 were eligible and included in the analysis with 11182 patients. High BMI (OR = 1.48, 95% CI [1.32, 1.67], MD = 1.35, 95% CI [0.58,2.12]) and insulin resistance (MD = 0.32, 95% CI [0.15, 0.49]) were associated with an increased risk of spontaneous abortion in PCOS patients undergoing ART. Older age (OR = 0.29, 95% CI [0.29, 0.44], MD = 2.01, 95% CI [0.04, 4.18]), embryonic chromosomal aberrations (OR = 0.75, 95%CI [0.31,1.77]), and hyperandrogenism (MD = 0.10, 95% CI [- 0.02, 0.22]) were not associated with the high spontaneous abortion rate in patients with PCOS. A subgroup analysis of BMI showed that there was no statistically significant difference in the effect between overweight and obesity on spontaneous abortion in PCOS patients undergoing ART (OR = 1.34, 95% [0.97, 1.85]). Conclusion High BMI and insulin resistance are two risk factors for an increased risk of spontaneous abortion in PCOS patients undergoing ART, and losing weight and mitigating insulin resistance may decrease the spontaneous abortion rate in these patients undergoing ART.
Aberrant Amplitude of Low-Frequency Fluctuations in Different Frequency Bands in Patients With Parkinson’s Disease

Previous studies reported abnormal spontaneous neural activity in Parkinson’s disease (PD) patients using resting-state functional magnetic resonance imaging (R-fMRI). However, the frequency-dependent neural activity in PD is largely unknown. Here, 35 PD patients and 35 age- and education-matched healthy controls (HCs) underwent R-fMRI scanning to investigate abnormal spontaneous neural activity of PD using the amplitude of low-frequency fluctuation (ALFF) approach within the conventional band (typical band: 0.01–0.08 Hz) and specific frequency bands (slow-5: 0.010–0.027 Hz and slow-4: 0.027–0.073 Hz). Compared with HCs, PD patients exhibited increased ALFF in the parieto-temporo-occipital regions, such as the bilateral inferior temporal gyrus/fusiform gyrus (ITG/FG) and left angular gyrus/posterior middle temporal gyrus (AG/pMTG), and displayed decreased ALFF in the left cerebellum, right precuneus, and left postcentral gyrus/supramarginal gyrus (PostC/SMG) in the typical band. PD patients showed greater increased ALFF in the left caudate/putamen, left anterior cingulate cortex/medial superior frontal gyrus (ACC/mSFG), left middle cingulate cortex (MCC), right ITG, and left hippocampus, along with greater decreased ALFF in the left pallidum in the slow-5 band, whereas greater increased ALFF in the left ITG/FG/hippocampus accompanied by greater decreased ALFF in the precentral gyrus/PostC was found in the slow-4 band (uncorrected). Additionally, the left caudate/putamen was positively correlated with levodopa equivalent daily dose (LEDD), Hoehn and Yahr (HY) stage, and disease duration. Our results suggest that PD is related to widespread abnormal brain activities and that the abnormalities of ALFF in PD are associated with specific frequency bands. Future studies should take frequency band effects into account when examining spontaneous neural activity in PD.
Development of a Dairy-Free Fermented Oat-Based Beverage With Enhanced Probiotic and Bioactive Properties

Lactobacillus fermentum PC1 with proven probiotic properties was used to ferment oats with added honey to develop a probiotic beverage with enhanced bioactive ingredients. The viable Lactobacilli were enumerated during the fermentation and storage at 4°C, as well as after exposure to simulated gastrointestinal tract conditions. Good survival was noted both during storage as well as when exposed to the in vitro digestive tract conditions. Comparative analysis of the antioxidant activity, total phenolic content, and phenolic composition indicated fermentation improved the total antioxidant capacity and phenolic acid concentration. An increase of more than 50% of gallic acid, catechin, vanillic acid, caffeic acid, p-coumaric acid, and ferulic acid was observed in the methanol extracts. Moreover, no significant decrease in the β-glucan content was noted during fermentation and storage. In conclusion, this fermented product has a great potential as a functional food with enhanced probiotic survival and increased bioactive ingredients.
What Influences Participation in Non-formal and Informal Modes of Continuous Vocational Education and Training? An Analysis of Individual and Institutional Influencing Factors

Participation in further education is a central success factor for economic growth and societal as well as individual development. This is especially true today because in most industrialized countries, labor markets and work processes are changing rapidly. Data on further education, however, show that not everybody participates and that different social groups participate to different degrees. Activities in continuous vocational education and training (CVET) are mainly differentiated as formal, non-formal and informal CVET, whereby further differences between offers of non-formal and informal CVET are seldom elaborated. Furthermore, reasons for participation or non-participation are often neglected. In this study, we therefore analyze and compare predictors for participation in both forms of CVET, namely, non-formal and informal. To learn more about the reasons for participation, we focus on the individual perspective of employees (invidual factors, job-related factors, and learning biography) and additionally integrate institutional characteristics (workplace and company-based characteristics). The results mainly show that non-formal CVET is still strongly influenced by institutional settings. In the case of informal CVET, on the other hand, the learning biography plays a central role.
A Spelling Paradigm With an Added Red Dot Improved the P300 Speller System Performance

The traditional P300 speller system uses the flashing row or column spelling paradigm. However, the classification accuracy and information transfer rate of the P300 speller are not adequate for real-world application. To improve the performance of the P300 speller, we devised a new spelling paradigm in which the flashing row or column of a virtual character matrix is covered by a translucent green circle with a red dot in either the upper or lower half (GC-RD spelling paradigm). We compared the event-related potential (ERP) waveforms with a control paradigm (GC spelling paradigm), in which the flashing row or column of a virtual character matrix was covered by a translucent green circle only. Our experimental results showed that the amplitude of P3a at the parietal area and P3b at the frontal–central–parietal areas evoked by the GC-RD paradigm were significantly greater than those induced by the GC paradigm. Higher classification accuracy and information transmission rates were also obtained in the GC-RD system. Our results indicated that the added red dots increased attention and visuospatial information, resulting in an amplitude increase in both P3a and P3b, thereby improving the performance of the P300 speller system.
Tumor-Associated Macrophages in Tumor Immunity

Tumor-associated macrophages (TAMs) represent one of the main tumor-infiltrating immune cell types and are generally categorized into either of two functionally contrasting subtypes, namely classical activated M1 macrophages and alternatively activated M2 macrophages. The former typically exerts anti-tumor functions, including directly mediate cytotoxicity and antibody-dependent cell-mediated cytotoxicity (ADCC) to kill tumor cells; the latter can promote the occurrence and metastasis of tumor cells, inhibit T cell-mediated anti-tumor immune response, promote tumor angiogenesis, and lead to tumor progression. Both M1 and M2 macrophages have high degree of plasticity and thus can be converted into each other upon tumor microenvironment changes or therapeutic interventions. As the relationship between TAMs and malignant tumors becoming clearer, TAMs have become a promising target for developing new cancer treatment. In this review, we summarize the origin and types of TAMs, TAMs interaction with tumors and tumor microenvironment, and up-to-date treatment strategies targeting TAMs.
Projected Climate Change Impacts on Hurricane Storm Surge Inundation in the Coastal United States

The properties of hurricanes directly influence storm surges; however, the implications of projected changes to the climate are unclear. Here, we simulate the storm surges of historical storms under present day and end of century climate scenarios to assess the impact of climate change on storm surge inundation. We simulate 21 storms that impacted the Gulf of Mexico and Atlantic Coasts of the continental U.S. from 2000 to 2013. We find that the volume of inundation increases for 14 storms and the average change for all storms is +36%. The extent of inundation increases for 13 storms, and the average change for all storms is +25%. Notable increases in inundation occur near Texas, Louisiana, Mississippi, the west coast of Florida, the Carolinas, and New Jersey. Our calculations of inundation volume and extent suggest that at the end of the century, we can expect hurricanes to produce larger storm surge magnitudes in concentrated areas, as opposed to surges with lower magnitudes that are widespread. We examine changes in maximum wind speed, minimum central pressure, translation speed, and radius of the 33 ms−1 wind to assess the impacts of individual storm characteristics on storm surge. We find that there is no single storm characteristic that directly relates to storm surge inundation or its climate induced changes. Even when all the characteristics are considered together, the resulting influences are difficult to anticipate. This is likely due to the complexity of the hydrodynamics and interactions with local geography. This illustrates that even as climate change research advances and more is known about projected impacts to hurricanes, implications for storm surge will be difficult to predict without explicit numerical simulation.
Individual Differences in Brain Responses: New Opportunities for Tailoring Health Communication Campaigns

Prevention neuroscience investigates the brain basis of attitude and behavior change. Over the years, an increasingly structurally and functionally resolved “persuasion network” has emerged. However, current studies have only identified a small handful of neural structures that are commonly recruited during persuasive message processing, and the extent to which these (and other) structures are sensitive to numerous individual difference factors remains largely unknown. In this project we apply a multi-dimensional similarity-based individual differences analysis to explore which individual factors—including characteristics of messages and target audiences—drive patterns of brain activity to be more or less similar across individuals encountering the same anti-drug public service announcements (PSAs). We demonstrate that several ensembles of brain regions show response patterns that are driven by a variety of unique factors. These results are discussed in terms of their implications for neural models of persuasion, prevention neuroscience and message tailoring, and methodological implications for future research.
Insights from protein film voltammetry into mechanisms of complex biological electron-transfer reactions

As the fundamental principles of long-range electron transfer (ET) in proteins are becoming well understood, interest is focusing on the mechanisms by which ET is coupled to chemical reactions such as ion transport and catalysis. Protein film voltammetry provides a powerful way to investigate these problems. The protein is immobilised on an electrode as an adsorbed electroactive film, typically a monolayer or less: then, by applying a potential, electrons are driven in and out of the active sites, resulting in diagnostically useful current signals. It is possible to resolve complex reactions over a wide dynamic range. For example, with cyclic voltammetry, scan rates exceeding 1000 V s−1 can be used to observe coupling reactions that occur in the sub-millisecond time domain. For enzymes, catalysis can be measured as a function of potential to reveal processes that are mechanistically informative and may be involved in controlling activity. This paper will illustrate the capabilities of this approach for mechanistic investigations into biological redox chemistry.
Using the Scientific Method as a Metaphor to Understand Modeling

Although modeling is used to address complex problems, it is difficult to study modeling itself with an easy to understand model. Many authors have proposed such a model of modeling, but a consensus on the meaning of the basic modeling concepts has yet to materialize. We claim that any proposal regarding the fundamentals of modeling should address several objectives, such as to focus on the concept of model and define what it is, how a model is created and how it relates to the entities it models or to explain the relationship between model and other basic concepts such as metamodel or (modeling-)language. In this paper, we present some of the most important elements of our proposal, named Scientific Method approach to Modeling (SMM). Our proposal uses the Scientific Method as a metaphor to explain the mechanisms of modeling, since it provides well-known mechanisms constantly utilized when developing or understanding models: validation, analysis, synthesis and analogy. Inspired by these mechanisms, our proposal addresses the notion of model by including several constructors that allow us to explain better several complex modeling mechanisms extensively discussed in the literature, such as the metamodel notion.
Building Information Modeling-Based Building Energy Modeling: Investigation of Interoperability and Simulation Results

There is increasing need to apply building information modeling (BIM) to low energy buildings, this includes building energy modeling (BEM). If a building energy model can be flawlessly generated from a BIM model, the energy simulation process can be better integrated within the design, can be more competent, and timesaving. However, concerns about both the reliability and integrity of the data transfer process and the interoperability between the BIM and BEM prevent any implementation of BIM-based energy modeling on a large scale. This study addresses the accuracy and integrity of BIM-based energy modeling by investigating how well Autodesk's Revit (BIM), in conjunction with two of the most used energy modeling programs (BEM) known as DesignBuilder and Virtual Environment (IES-ve), were integrated in terms of interoperability, including location and weather files, geometry, construction and materials, thermal zones, occupancy operating schedules, and HVAC systems. All misrepresented data during the interoperability process were identified, followed by benchmarking between the BIM-based energy modeling simulation outcomes and the actual energy consumption of the case study, to assess the reliability of the process. The investigation has revealed a number of interoperability issues regarding the BIM data input and BEM data interpretation. Overall, BIM-based energy modeling proved to be a promising tool for sustainable and low energy building design, however, the BIM to BEM process is a non-standardized method of producing building energy models as it varies from one modeler to another, and the BIM to BEM process. All these might slow down any possible application for the process and might cause some uncertainties for the professionals in the field applying it.
Experiences of Patients With Borderline Personality Disorder With Imagery Rescripting in the Context of Schema Therapy—A Qualitative Study

Imagery Rescripting (IR) is a therapeutic technique that is used in a wide spectrum of therapeutic methods for various mental disorders. As an important component of Schema Therapy (ST), IR is frequently used in the treatment of patients with borderline personality disorder (BPD). However, little is known about how IR is experienced by individuals with BPD. The aim of this study was to explore BPD patients' experiences with receiving IR. Qualitative data were collected through semi-structured interviews with 21 individuals (86% females) with a primary diagnosis of BPD who received IR within their ST treatment. Interview data were analyzed following the procedures of qualitative content analysis. Participants reported various effects of IR including initial high emotionality and exhaustion. Long-term effects included a better understanding of schemas and an improvement regarding emotion regulation and interpersonal relationships. Participants reported factors hindering the successful implementation of IR, such as external noise, stress, and a fast pace during IR. Facilitating factors included adequate time for debriefing, a transparent structure, and preparation of IR as well as the therapist providing safety. Implications of the findings for optimizing IR in clinical practice are discussed.
Informal caregiver burden and influencing factors in gynaecological oncology patients hospitalized for chemotherapy: a cross-sectional study

Objective To determine the level and influencing factors of informal caregiver burden in gynaecological oncology inpatients receiving chemotherapy. Methods This cross-sectional study enrolled gynaecological oncology patients and their informal caregivers between May 2018 and November 2018 and measured the caregivers’ burden using the Caregiver Burden Inventory. The influencing factors were evaluated with univariate regression analysis and multivariate linear stepwise regression analysis. Results A total of 138 patients and their informal caregivers completed the questionnaire. The mean ± SD total informal caregiver burden score was 53.18 ± 10.97. The highest mean ± SD score was recorded in the dimension of time-dependent burden (14.28 ± 2.74), followed by developmental burden (13.65 ± 2.15), physical burden (10.52 ± 2.07), social burden (7.61 ± 2.58) and emotional burden (7.12 ± 1.43). Multivariate analysis showed that the informal caregiver’s sex, relationship to the patient, daily duration of care, presence of chronic health problems and the duration of the patient’s disease were factors influencing the level of caregiver burden. Conclusions The informal caregivers of gynaecological cancer patients hospitalized for chemotherapy experience a moderate level of burden. Nursing measures should be considered to reduce informal caregiver burden and improve the quality of lives of both patients and their caregivers.
A joint discriminative-generative approach for tumour angiogenesis assessment in computational pathology. (Une approche commune discriminative-générative pour l'évaluation de l'angiogenèse tumorale en pathologie computationnelle)

of the chapter In this chapter, we, first give an overview about cancer mechanism. We detail, the importance of histopathology grading by Pathologists and its implication in patient prognosis and therapies. We focus on both breast cancer and colorectal cancer based on the alarming statistics reported recently by WHO. Finally, we emphasis the role of blood vessel as a major component of the tumour micro-environment matrix and its interaction with other tumour micro-environment components.
Determination of Heavy Metals in Water and Tissues of Crucian Carp (Carassius auratus Gibelio) Collected from Subsidence Pools in Huainan Coal Fields (China)

Heavy metals are an important class of chemical contaminants and food is a major vehicle for entry into the ecosystem. Crucian carp (Carassius auratus Gibelio) is an aquatic organism affected by metals and constitutes a major source of contaminated food in the subsidence area. Therefore, cadmium, copper, lead, and zinc were determined in the water of subsidence pools and different tissues of Carassius auratus Gibelio. In addition, the metal concentrations in water and fish from this study were compared with national and international quality guidelines and literature values. The concentrations of metals in water were in the range of 4.05 to 15.49 µg L−1 for zinc, 3.03 to 5.43 µg L−1 for lead, 0.33 to 1.43 µg L−1 for cadmium, and 7.25 to 26.93 µg L−1 for copper, which are within the permissible levels for culturing fish. Metal concentrations in tissues (viscera, gills, and muscle) varied significantly depending on the site. In Carassius auratus Gibelio, the accumulation of metals was in the sequence viscera > gills > muscle. Metal concentrations in muscle (Zn, 8.63 to 10.5 mg kg−1; Pb, 0.12 to 0.36 mg kg−1; Cd, 0.005 to 0.01 mg kg−1; Cu, 1.14 to 1.77 mg kg−1) of Carassius auratus Gibelio were far below the permissible limits proposed by Food and Agriculture Organization/World Health Organization and Chinese legislation, suggesting that the fish were safe for human consumption. Correlations between metal concentrations in tissues of Carassius auratus Gibelio and in water are also reported.
Psychological Well-Being, Marital Satisfaction, and Parental Burnout in Iranian Parents: The Effect of Home Quarantine During COVID-19 Outbreaks

Coronavirus disease 2019 (COVID-19), as an infectious disease, is now prevalent in many countries around the world, which has recently led many governments to home quarantine and impose penalties for violating quarantine. Concerns and stress caused by lockdown and social isolation led to personal and interactive reactions in some families, which are also culturally important to address. This study was administrated to study the psychological well-being and the effect of home quarantine on marital satisfaction (MS) and parental burnout (PB) from parenting responsibilities during the prevalence of COVID-19 in Iranian parents. A total of 213 parents (140 mothers and 73 fathers) voluntarily participated in the online survey in the period of February to mid-April 2020 and completed the 5-item index of the well-being of the World Health Organization (WHO-5), the Kansas Marital Satisfaction Scale (KMSS), and the Parental Burnout Assessment (PBA). The results showed that the effect of home quarantine on MS and PB was not significant in parents (p > 0.01). The interactive effect of home quarantine and gender was not significant on MS and PB (p > 0.01). In addition, the mothers significantly reported higher PB than the fathers, but the fathers had higher scores in MS and psychological well-being (p < 0.01). The effect of some demographic factors on the studied variables was also significant. Supportive resources in family-based culture may play an essential role to reduce the negative effects of stressful situations on family interactions.