Miracle-dz/UniFAR-FTUs huggingface dataset:
Myocardial Injury Caused by Chronic Alcohol Exposure—A Pilot Study Based on Proteomics

Chronic alcohol exposure can cause myocardial degenerative diseases, manifested as cardiac insufficiency, arrhythmia, etc. These are defined as alcoholic cardiomyopathy (ACM). Alcohol-mediated myocardial injury has previously been studied through metabolomics, and it has been proved to be involved in the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway concerning unsaturated fatty acids biosynthesis and oxidative phosphorylation, which tentatively explored the mechanism of ACM induced by chronic drinking. To further study alcohol-induced myocardial injury, myocardial specimens from a previously successfully established mouse model of ACM were subjected to histological, echocardiographic, and proteomic analyses, and validated by real-time quantitative polymerase chain reaction (qPCR). Results of histopathology and echocardiography showed the hypertrophy of cardiomyocytes, the dilation of ventricles, and decreased cardiac function. Proteomic results, available via ProteomeXchange with identifier PXD032949, revealed 56 differentially expressed proteins (DEPs) were identified, which have the potential to be involved in the KEGG pathway related to fatty acid biosynthesis disorders, lipid metabolism disorders, oxidative stress, and, ultimately, in the development of dilated cardiomyopathy (DCM). The present study further elucidates the underlying effects of myocardial injury due to chronic alcohol intake, laying a foundation for further studies to clarify the potential mechanisms of ACM.
Supercritical Impregnation of Mango Leaf Extract into PLA 3D-Printed Devices and Evaluation of Their Biocompatibility with Endothelial Cell Cultures

The addition of natural substances with pharmacoactive properties to polymeric biomedical devices would provide beneficial regarding the assimilation of these endoprostheses when implanted into a patient’s body. The added drug would facilitate endothelization by regulating the inflammatory processes that such interventions entail, preventing contamination hazards and favoring the angiogenesis or formation of blood vessels in the tissue. The present work used mango leaf extract (MLE) obtained through pressurized ethanol for this purpose. Polylactic acid (PLA) in the form of filaments or 3D-printed disks was impregnated by means of supercritical technology with MLE for the culture essays. The release kinetics has been studied and the polymer matrices have been examined by scanning electron microscopy (SEM). The impregnated devices were subjected to in vitro culture of colony-forming endothelial cells. The influence of the different impregnation conditions used for the production of the MLE impregnated polymeric devices on the development of the cell culture was determined by fluorescence microscopy. The best results were obtained from the calcein cultures on 35 °C MLE impregnated into 3D-printed polymer disks.
A Scoping Review on Kindness in the Work Environment

The paper aims to provide new, theoretical insights on kindness at work to counter bullying on the job. Studies have shown that a range of kindness acts and activities will boost happiness and job satisfaction at work and spillover to the home. Based on the research objectives, the findings identified elements of kindness and unkindness and the built environment's effects on work happiness. The scoping review method and PRISMA analysis revealed that kindness in the work environment depends on the organizational culture, leadership, and organization size. Organizational leaders' exemplary behavior sets the kindness culture towards kindness and happiness at work. The study limitation was the timeframe. Thus, a survey is recommended for empirical evidence to support the theoretical and conceptual frameworks. Keywords: Kindness; Civility; Bullying; Built Environment eISSN: 2398-4287 © 2022. The Authors. Published for AMER ABRA CE-Bs by E-International Publishing House, Ltd., UK. This is an open-access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer-review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians/Africans/Arabians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia. DOI: https://doi.org/10.21834/ebpj.v7i20. 3304
Predictive Factors for Renal Response in Lupus Nephritis: A Single-center Prospective Cohort Study

Objective To identify the predictive factors for renal response in patients with lupus nephritis (LN). Methods Patients and data were extracted from a prospective systemic lupus erythematosus cohort in Korea, in which clinical data were collected at 0, 3, 6, and 12 months after induction therapy. Treatment response of LN were evaluated as a complete response (CR), partial response (PR), or non-response (NR) at 3, 6, and 12 months, respectively. Predictive factors for CR at 6 months were evaluated using multivariable Poisson regression analysis. Results A total of 75 patients with LN who underwent biopsy was enrolled. The mean age at diagnosis of LN was 28.9±9.7 years, and 68 (90.7%) were female. The frequencies of classes III, IV, III+V, IV+V, and V were 20.0%, 44.0%, 16.0%, 12.0%, and 8.0%, respectively. Compared to relapsed LN, new-onset LN showed a lower percentage of glomerulosclerosis (45.5% vs. 76.2%, p=0.013). The overall proportions of CR, PR, and NR at 6 and 12 months were 52.0%, 26.7%, 21.3% and 50.7%, 24.0%, 25.3%, respectively. In multivariate analysis, age at enrollment (odds ratio [OR]=1.02, p=0.022), relapsed LN (OR=0.71, p=0.037), anti-Ro antibody (OR=0.67, p=0.014), and class III LN (OR=1.48, p=0.001) were associated with CR at 6 months. Conclusion In our prospective cohort, class III LN was a good predictive factor for CR at 6 months in patients with LN, whereas younger age, relapsed LN, and anti-Ro antibody were poor predictive factors.
High Mobility Group A1 (HMGA1): Structure, Biological Function, and Therapeutic Potential

High mobility group A1 (HMGA1) is a nonhistone chromatin structural protein characterized by no transcriptional activity. It mainly plays a regulatory role by modifying the structure of DNA. A large number of studies have confirmed that HMGA1 regulates genes related to tumours in the reproductive system, digestive system, urinary system and haematopoietic system. HMGA1 is rare in adult cells and increases in highly proliferative cells such as embryos. After being stimulated by external factors, it will produce effects through the Wnt/β-catenin, PI3K/Akt, Hippo and MEK/ERK pathways. In addition, HMGA1 also affects the ageing, apoptosis, autophagy and chemotherapy resistance of cancer cells, which are linked to tumorigenesis. In this review, we summarize the mechanisms of HMGA1 in cancer progression and discuss the potential clinical application of targeted HMGA1 therapy, indicating that targeted HMGA1 is of great significance in the diagnosis and treatment of malignancy.
Bi-modal tissue-mimicking breast phantoms: comparison between the performance of agar- and gelatin-based phantoms

Tissue-mimicking phantoms represent a key point for the development of biomedical systems for diagnostic imaging. In this paper, new recipes for tissue-mimicking breast phantoms are proposed and tested, both dielectrically and mechanically. Phantoms mimicking human breast neoplastic tissues are considered, as they are anatomically stiffer than the surrounding healthy tissues. In our recipes, only cheap, easy-to-manage and safe components are involved, and the performance of two solidifying agents (i.e., gelatin and agar) are evaluated both from a dielectric and a mechanical point of view. Dielectric measurements are performed from 500 MHz to 40 GHz, and mechanical tests are performed with the unconfined compression approach, using a preload of 0.2 N and a test speed of 0.5 mm/min. This analysis shows that agar is more suitable for the fabrication of stiffer phantoms as compared to gelatin.
Demystifying and Mitigating TCP Capping

Today’s Internet user experience greatly depends on some user-perceived network metrics, such as throughput and latency. To improve these metrics, many Internet content providers build the content delivery network (CDN) to provide their services. Generally, CDNs adopt TCP as their transport protocol. A recent line of work improves TCP by proposing novel congestion control algorithms. However, we measure TCP performance in the production CDN and identify an interesting phenomenon termed TCP capping. When the flows experience TCP capping, the fixed-size receive window (rwnd) restricts these flows from fully utilizing network bandwidth. Through in-depth analysis, we demystify that the root cause of TCP capping is an inappropriate constraint on rwnd due to not considering the receiver’s processing capability. To mitigate it, this paper proposes a server-side scheme Apollo and a client-side scheme Artemis for Internet content providers and users, respectively. Apollo probes the receiver’s processing capability and assists the sender in packet sending. And Artemis adjusts the receive buffer in light of the receiver’s processing capability. In our evaluation, compared to vanilla TCP, TCP (w/ Apollo) and TCP (w/ Artemis) shorten flow completion time by up to 91.8% and 94.9%, respectively.
Preclinical Immunogenicity and Efficacy of a Multiple Antigen-Presenting System (MAPSTM) SARS-CoV-2 Vaccine

Despite the remarkable success of SARS-CoV-2 vaccines, the rise of variants, some of which are more resistant to the effects of vaccination, highlights the potential need for additional COVID-19 vaccines. We used the Multiple Antigen-Presenting System (MAPS) technology, in which proteins are presented on a polysaccharide polymer to induce antibody, Th1, Th17 and CD8+ T cell responses, to engineer a novel vaccine targeting SARS-CoV-2. This vaccine contains a fragment of the spike (S) protein receptor-binding domain (RBD) sequence of the original D614G strain and was used to immunize nonhuman primates (NHP) for assessment of immunological responses and protection against SARS-CoV-2 challenge. The SARS-CoV-2 MAPS vaccine generated robust neutralizing antibodies as well as Th1, Th17 and cytotoxic CD8 T-cell responses in NHPs. Furthermore, MAPS-immunized NHPs had significantly lower viral loads in the nasopharynx and lung compared to control animals. Taken together, these findings support the use of the MAPS platform to make a SARS-CoV-2 vaccine. The nature of the platform also could enable its use for the inclusion of different variants in a single vaccine.
ANALISIS UNDANG-UNDANG ITE BERDASARKAN ASAS PEMBENTUKAN PERATURAN PERUNDANG-UNDANGAN DI INDONESIA

Artikel ini memiliki tujuan untuk mengetahui apakah Undang-Undang Nomor 11 Tahun 2008 tentang Informasi dan Transaksi Elektronik tidak sesuai dengan asas pembentukan peraturan perundang-undangan yang berlaku dan diundangkan dalam Undang-Undang Nomor 12 Tahun 2011 tentang Pembentukan Peraturan Perundang-Undangan. Produk hukum, Undang-Undang tersebut berfungsi sebagai alat kontrol negara terhadap sistem informasi dan transaksi elektronik secara bebas serta sudah semestinya produk hukum tersebut harus memenuhi asas-asas pembentukan peraturan perundang-undangan yang baik agar dapat dengan mudah masuk dalam komunitas masyarakat. Perlu dilihat dan ditinjau apakah Undang-Undang Nomor 11 Tahun 2008 ini sesuai atau tidak dengan asas pembentukan peraturan perundang-undangan. Pada penelitian ini menggunakan penelitian hukum normatif pada peraturan tertulis, sehingga penelitian ini erat kaitannya dengan kepustakaan karena membutuhkan data pendukung yang diperoleh dari perpustakaan. Pada Undang-Undang Nomor 11 Tahun 2008 tentang Informasi dan Transaksi Elektronik masih terdapat ketidaksesuaian terhadap asas pembentukan peraturan perundang-undangan. Dengan terdapatnya kelemahan dalam Undang-Undang Informasi dan Transaksi Elektronik maka tampaknya perlu diadakannya peninjauan kembali agar tidak terdapat kesalahan penafsiran.
Variation of TEC Over South Africa During a Geomagnetic Storm

The ionosphere affects how radio waves propagate from the satellite to ground based receivers. During geomagnetic storms the Total Electron Content (TEC) varies due to the driving forces of the storm. The South African National Space Agency (SANSA) near-real time TEC map version 2 was used to show how the ionosphere varied during the geomagnetic storm of 19 - 23 Dec 2021. The Global Positioning System (GPS), ionosondes, and the quiet-time AFriTEC model were compared during the five day period. During the period of analysis, the Root Mean Squared Error (RMSE) were greater during the geomagnetic storm as compared with quiet days. The decrease in TEC were observed on 20 and 21 Dec 2021 during a geomagnetic storm period. The estimated TEC from the GPS and ionosode had similar temporal variations and magnitudes.
Mo2C as Pre-Catalyst for the C-H Allylic Oxygenation of Alkenes and Terpenoids in the Presence of H2O2

In this study, commercially available molybdenum carbide (Mo2C) was used, in the presence of H2O2, as an efficient pre-catalyst for the selective C-H allylic oxygenation of several unsaturated molecules into the corresponding allylic alcohols. Under these basic conditions, an air-stable, molybdenum-based polyoxometalate cluster (Mo-POM) was formed in situ, leading to the generation of singlet oxygen (1O2), which is responsible for the oxygenation reactions. X-ray diffraction, SEM/EDX and HRMS analyses support the formation mainly of the Mo6O192− cluster. Following the proposed procedure, a series of cycloalkenes, styrenes, terpenoids and methyl oleate were successfully transformed into hydroperoxides. After subsequent reduction, the corresponding allylic alcohols were produced with good yields and in lab-scale quantities. A mechanistic study excluded a hydrogen atom transfer pathway and supported the twix-selective oxygenation of cycloalkenes on the more sterically hindered side via the 1O2 generation.
Wideband Circularly Polarized Cavity-Backed Dielectric Resonator Antenna With Low RCS for Aerial Vehicle Communications

This letter explains the design of a wideband circularly polarized dielectric resonator antenna (DRA) with a dual-cylindrical conformal cavity for aerial applications. The proposed dielectric resonator (DR) element uses multilayer cross-shaped elements of varying dimensions with an off-centered circular slot that is inserted inside the DR geometry. Combining the wideband DRA with a conformal cavity (bending angle, α = 5°) that provides wider impedance bandwidth of 111% from 5.02 to 17.52 GHz and axial ratio bandwidth of 32.29% from 6.18 to 8.56 GHz. The proposed antenna provides a higher gain of 10.77 dBi at 8.5 GHz, gain values better than 7.21 dBi, and radiation efficiency better than 90% for the complete band. Also, the proposed antenna provides good radar cross-section reduction mechanism for the entire working band.
Seed Protection of Solanum lycopersicum with Pythium oligandrum against Alternaria brassicicola and Verticillium albo-atrum

Pythium oligandrum, strain M1, is a soil oomycete successfully used as a biological control agent (BCA), protecting plants against fungal, yeast, and oomycete pathogens through mycoparasitism and elicitor-dependent plant priming. The not yet described Pythium strains, X42 and 00X48, have shown potential as BCAs given the high activity of their secreted proteases, endoglycosidases, and tryptamine. Here, Solanum lycopersicum L. cv. Micro-Tom seeds were coated with Pythium strains, and seedlings were exposed to fungal pathogens, either Alternaria brassicicola or Verticillium albo-atrum. The effects of both infection and seed-coating on plant metabolism were assessed by determining the activity and isoforms of antioxidant enzymes and endoglycosidases and the content of tryptamine, amino acids, and heat shock proteins. Dual culture competition testing and microscopy analysis confirmed mycoparasitism in all three Pythium strains. In turn, seed treatment significantly increased the total free amino acid content, changing their abundance in both non-infected and infected plants. In response to pathogens, plant Hsp70 and Hsp90 isoform levels also varied among Pythium strains, most likely as a strategy for priming the plant against infection. Overall, our results show in vitro mycoparasitism between Pythium strains and fungal pathogens and in planta involvement of heat shock proteins in priming.
Pharmacologically Active Phytomolecules Isolated from Traditional Antidiabetic Plants and Their Therapeutic Role for the Management of Diabetes Mellitus

Diabetes mellitus is a chronic complication that affects people of all ages. The increased prevalence of diabetes worldwide has led to the development of several synthetic drugs to tackle this health problem. Such drugs, although effective as antihyperglycemic agents, are accompanied by various side effects, costly, and inaccessible to the majority of people living in underdeveloped countries. Medicinal plants have been used traditionally throughout the ages to treat various ailments due to their availability and safe nature. Medicinal plants are a rich source of phytochemicals that possess several health benefits. As diabetes continues to become prevalent, health care practitioners are considering plant-based medicines as a potential source of antidiabetic drugs due to their high potency and fewer side effects. To better understand the mechanism of action of medicinal plants, their active phytoconstituents are being isolated and investigated thoroughly. In this review article, we have focused on pharmacologically active phytomolecules isolated from medicinal plants presenting antidiabetic activity and the role they play in the treatment and management of diabetes. These natural compounds may represent as good candidates for a novel therapeutic approach and/or effective and alternative therapies for diabetes.
Indigenous entomopathogenic nematode as biocontrol agents for insect pest management in hilly regions

The present investigation mainly emphasized on the development and use of entomopathogenic nematodes (EPNs) as a bio-insecticide. The success in controlling insect pests in the soil environments increased the production and use of the adapted indigenous EPNs species for insect management in the fields. EPNs as biocontrol agents were capable for high virulence, easy for application, safe for non-target animals and eco-friendly in nature. These nematodes have ubiquitous nature. These occur in low population in their natural habitat which was mass multiplied in the laboratory. In the present investigation, 5 concentrations (30IJs, 60IJs, 90IJs, 120IJs and 150IJs) of Heterorhabditis bacteriophora strain S15 were applied against the 3rd and 4th instar larvae of four major agricultural insect pests, namely Helicoverpa armigera, Spodoptera litura, Agrotis segetum and Mythimna separata under laboratory conditions at different time exposure (24, 48, 72 and 96 hr). It was observed that the 3rd and 4th larval instars of all 4 insects (H. armigera, S. litura, A. segetum and M. separata) were highly susceptible for the pathogenesis caused by H. bacteriophora Sirmaur isolates. Amongst all insects, both the larval instars of M. separata are highly susceptible for EPNs infection with highest 96% and 98% mortality in highest dose @150IJs. In 3rd instar larvae of other insects such as H. armigera, S. litura and A. segetum larval mortality ranges from 84%, 92% and 94% respectively. Among 4th instar larvae of H. armigera, S. litura and A. segetum the pathogenicity varies from 88%, 94% and 96% respectively. The recorded median lethal concentration (LC50) in 3rd instar larvae of H. armigera, S. litura, A. segetum and M. separata varies from 36.15, 30.05, 30.97 and 23.8. Similarly in 4th instar larvae of H. armigera, S. litura, A. segetum and M. separata, LC50 ranged from 31.41, 28.64, 26.92 and 20.64 respectively. Statistically significant variations were observed in the data recorded on the mortality, in all the treatments. EPNs are the best weapon to overcome insect resistance problems and must be employed to manage insect population.
Geopolymer concrete with ground granulated blast furnace slag and black rice husk ash

An experimental study on the strength and durability properties of geopolymer concrete prepared using the ground granulated blast furnace slag and black rice husk ash is presented in the paper. The geopolymer concrete was initially prepared with ground granulated blast furnace slag as the primary binder instead of cement, and then blast furnace slag was replaced with black rice husk ash. The addition of more than 10 % of black rice husk ash in geopolymer concrete retards the strength development, although such strength values are still above the target strength for up to 20 % replacement levels.
A kNGR Peptide-Tethered Lipid–Polymer Hybrid Nanocarrier-Based Synergistic Approach for Effective Tumor Therapy: Development, Characterization, Ex-Vivo, and In-Vivo Assessment

The present study aims to design, develop and characterize kNGR (Asn-Gly-Arg) peptide-conjugated lipid–polymer-based nanoparticles for the target-specific delivery of anticancer bioactive(s), i.e., Paclitaxel (PTX). The kNGR-PEG-DSPE conjugate was synthesized and characterized by using spectral analysis. The dual-targeted PLGA–lecithin–PEG core-shell nanoparticles (PLNs-kNGR-NPs) were synthesized using a modified nanoprecipitation process, and their physiological properties were determined. The results support that, compared to other NPs, PLNs-kNGR-NPs are highly cytotoxic, owing to higher apoptosis and intracellular uptake. The significance of rational nanoparticle design for synergistic treatment is shown by the higher tumor volume inhibition percentage rate (59.7%), compared to other designed formulations in Balb/c mice in the HT-1080 tumor-induced model. The overall results indicate that the PLNs-kNGR-NPs-based hybrid lipid–polymer nanoparticles present the highest therapeutic efficacy against solid tumor overexpressing the CD13 receptors.
Legal Personality of ASEAN as the Subject of International Law: Contemporary Developments

The Organization of Southeast Asian Nations (ASEAN) has unique characteristics, apart from the legal systems in Southeast Asian countries that are different from one another, but also have different historical aspects. If ASEAN is compared to the European Union, which has the same legal vision, characteristics of society, and even a uniform financial system, ASEAN does not yet have this uniformity. This study aims to identify the legal personality for ASEAN as a subject of international law. This study looks at various theories and concepts regarding international organizations as subjects of international law. This study confirms that the basis for ASEAN legal personality as a subject of international law can be seen in the ASEAN Charter, however, this form of legal personality is still limited.
Science communication in the face of skepticism, populism, and ignorance: what ‘Don’t Look Up’ tells us about science denial — and what it doesn’t

‘Don’t Look Up’ tells the story of a team of astrophysicists whose efforts to warn politicians, media makers, and the public about an apocalyptic comet impact on planet Earth are undermined by fundamental skepticism toward their expertise. On the one hand, the film offers a rich portrayal of contemporary anti-science sentiments, their societal conditions, and the media and communication ecology surrounding them. But on the other hand, ‘Don’t Look Up’ ignores and exaggerates several facets of those sentiments and the communicative settings in which they spread. This commentary analyzes this contrast through a science communication lens: it scrutinizes the (mis)representation of science denial and science communication in ‘Don’t Look Up’ — and aims to inspire further debate about portrayals of anti-science phenomena and potential remedies within popular media.