Miracle-dz/UniFAR-FTUs huggingface dataset:
Role of low circulating FSH

Two or three follicular waves develop during the bovine oestrous cycle (Ginther et al., 1989). Each wave is preceded by a surge in circulating FSH (Adams et al., 1992). The FSH surge and the resulting follicular wave that develop at the start of the oestrous cycle are termed surge 1 and wave 1, and are followed in about 10 days by surge 2 and wave 2. When the largest follicle of a wave reaches a mean diameter of 8.5 mm, the follicles begin to deviate in diameter into a single dominant follicle and several subordinate follicles (Ginther et al., 2001a). The FSH concentrations continue to decrease for approximately 1 day after the start of deviation in follicle diameter. Surge 2 stimulates the emergence of follicles 4 mm in diameter from wave 2 about 10 days after emergence of wave 1 or 7 days after the start of deviation in follicle diameter of wave 1. The changes in the concentrations of FSH and other hormones during the interval between surges 1 and 2 have not been described adequately. Previous studies used reference points near the beginning of wave 1 (Badinga et al., 1992; Sunderland et al., 1996; Evans et al., 1997) or normalized each wave and associated hormone concentrations to follicle emergence (Adams et al., 1992) or deviation (Kulick et al., 2001), thereby obscuring the mean pattern of the circulating hormone concentrations during the transition between surges. The decrease in FSH concentrations after deviation in follicle diameter in surge 1 and maintenance of FSH at low concentrations after follicle deviation apparently assure continued FSH deprivation of the subordinate follicles (Ginther et al., 2001a). In addition, the low FSH concentrations may delay the emergence of the next follicular wave until surge 2 develops appropriate FSH concentrations. The depression of circulating FSH during this time has been attributed to the secretion of oestradiol and inhibin by the dominant follicle of wave 1 (for a review, see Ginther et al., 2001a). The dominant follicle may also secrete factors other than oestradiol and inhibin that suppress other follicles either directly (Armstrong and Webb, 1997) or through reduced circulating FSH. In this regard, a steroiddepleted fraction of follicular fluid suppressed follicle development in cattle even though the injected follicular fluid was > 95% free of inhibin (Law et al., 1992) and suppressed both FSH and follicles despite the injection of an inhibin antiserum with the follicular fluid (Wood et al., 1993). Administration of FSH during the transition between surges 1 and 2 can be expected to shorten the interval between waves 1 and 2, if low FSH concentrations account for the duration of the interval in control heifers. In one study, an FSH-rich pituitary extract administered 5 days after ovulation shortened the interval from treatment to the emergence of wave 2 (Bodensteiner et al., 1996). However, the interpretation was obscured by the ovulation of the dominant follicle of wave 1 in most heifers. In another Role of low circulating FSH concentrations in controlling the interval to emergence of the subsequent follicular wave in cattle
PROTECTIVE EFFECT OF ANACARDIUM OCCIDENTALE AQUEOUS LEAF EXTRACTS ON LEAD-INDUCED HEPATOTOXICITY IN MALE WISTAR RATS: HISTOLOGICAL AND BIOCHEMICAL EVALUATION

This study investigated the protective effect of Anacardium occidentale (A.O) aqueous leaf extract on lead acetateinduced hepatotoxicity in male Wistar rats. Thirty male rats were divided randomly into six equal groups. Group 1 (normal control), received 0.5ml normal saline; group 2 received 50mg/kg body weight (b.wt) lead acetate (Pb) for 28 days; groups 3 & 4 received A.O (150 and 300 mg/kg b.wt respectively) for first 14 days and Pb (50mg/kg b.wt) for the next 14 days; group 5 received concurrently (150 mg/kg b.wt A.O and 50 mg/kg b.wt Pb) for 28 days; group 6 received concurrently (300 mg/kg b.wt A.O and 50 mg/kg b.wt Pb) for a period 28 days. Animals were sacrificed and blood sample collected for assay of activity of serum liver enzymes; Alkaline phosphatase (ALP), Alanine aminotransferase (ALT) and Aspartate aminotransferase (AST). Result on histological analysis in lead only treated rats revealed vacuolar degeneration, necrosis of the hepatocytes and biochemical evaluation showed significant increases (p<0.05) in the activities of serum liver enzymes compared to normal control group indicative of hepatotoxicity. Pre and co-administrations of A.O at high and low doses to lead exposed rats, showed significant (p<0.05) reduction in serum levels of liver enzymes and cytoarchitectural preservation of liver tissue against lead intoxication. In conclusion, result obtained from this study, suggests that A.O possesses protective potentials against lead acetate-induced hepatotoxicity.
1 Genotypic and Phenotypic Characterization of Methicillin-Susceptible Staphylococcus 1 aureus Isolates Misidentified as Methicillin-Resistant Staphylococcus aureus by the BD 2 GeneOhm TM MRSA Assay 3 4 5

24 Twenty-three nasal swab samples that tested positive for methicillin-resistant 25 Staphylococcus aureus (MRSA) on initial testing by the BD GeneOhm MRSATM Assay (BD26 MRSA PCR) (BD GeneOhm, San Diego, CA) were culture positive only for methicillin27 susceptible S. aureus (MSSA) from an enrichment broth. The 23 recovered isolates were 28 confirmed as MSSA by a variety of phenotypic methods including the BD PhoenixTM Automated 29 Microbiology System (BD Diagnostics, Sparks, MD); Oxacillin Screening Agar (BD Diagnostics 30 Sparks, MD); BBL CHROMagarTM MRSA (BD Diagnostics Sparks, MD); a PBP2’ assay 31 (Denka Seiken Co., Tokyo, Japan); and susceptibilities performed by Mueller-Hinton agar with 32 oxacillin. All were positive by nuc PCR, specific for S. aureus, but negative for mecA with one 33 exception. Isolates were characterized using multiplex PCR methodology to determine structural 34 types and variants (SCCmec typing); additional PCR reactions were performed for the detection 35 of the ccr and mec complexes, the junkyard regions as well as the Panton-Valentine leukocidin 36 (PVL). Pulsed‐field gel electrophoresis (PFGE) was used to determine clonality. One 37 phenotypic MSSA isolate contained an intact SCCmec. Twelve MSSA isolates tested positive 38 for MRSA by the BD-MRSA PCR because of amplification of the mec priming site flanking the 39 SCC insertion point although these isolates lacked mecA. The 10 remaining isolates were not 40 MRSA and tested as MSSA by phenotypic and genotypic assays. In our patient population, 41 diagnostic and surveillance testing and subsequent infection control practices may be impacted 42 by the frequency of these excision events when using the BD-MRSA PCR for MRSA detection. 43 on M arch 2, 2020 by gest ht://jcm . sm . rg/ D ow nladed fom
Effects of Different Sources of Organic Waste Application on the Growth and Biomass Production of Kenaf (Hibiscus cannabinus L.)

Growth and Biomass Production of Kenaf (Hibiscus cannabinus L.) Md. Shayeb Shahariara*, Shahrima Tahsina, Md. Nasimul Ganib and Shah Muhammad Imamul Huqc aSoil and Environment Section, Biological Research Division, Bangladesh Council of Scientific and Industrial Research (BCSIR), Dr. Qudrat-I-Khuda Road, Dhanmondi, Dhaka-1205, Bangladesh bSoil Science Division, Bangladesh Jute Research Institute (BJRI), Manik Mia Avenue, Sher-e-Bangla Nagar, Dhaka-1207, Bangladesh cDepartment of Soil Water and Environment, University of Dhaka, Dhaka-1000, Bangladesh
Functional connectivity between the parahippocampal gyrus and themiddle temporal gyrus moderates the relationship between problematic mobile phone use and depressive symptoms: Evidence from a longitudinal study

Background and aim: Problematic mobile phone use (PMPU) is prevalent and increases the risk for a variety of health problems. However, few studies have explored the neural mechanisms that might render adolescents more or less vulnerable. Here, we aimed to identify whether PMPU is associated with depressive symptoms and whether this relationship is moderated by intrinsic functional connectivity (iFC) which is associated with PMPU. Methods: In this longitudinal study, we included 238 students (mean age5 19.05, SD5 0.81) that came from a university in Hefei, China. They all finished MRI scans at baseline and completed questionnaires both at baseline and 1 year later. A self-rating questionnaire for adolescent problematic mobile phone use and depression anxiety stress scale-21 were used to assess PMPU and depressive symptoms. We first assessed the relationship between PMPU and depressive symptoms using an autoregressive cross-lagged model. Then, we detected the brain regions that were associated with PMPU. Moreover, the neuroimaging results were extracted to explore whether the iFC of these brain regions moderated the relationship between PMPU and depression. Results: Consistent with our hypotheses, PMPU was positively associated with depressive symptoms, and the relationship between PMPU and depressive symptoms was moderated by iFC of the left parahippocampal gyrusright middle temporal gyrus both at baseline and after 1 year (b 5 0.554, P 5 0.003; b 5 0.463, P 5 0.016, respectively). Conclusions: These results advance the understanding of PMPU and suggest that iFC of the left parahippocampal gyrus-right middle temporal gyrus may be a neurobiological contributor to its relationship with depressive symptoms. Journal of Behavioral Addictions DOI: 10.1556/2006.2021. 00090 © 2021 The Author(s)
Effect of Aqueous Extract of Melia azedarach on the some Biochemical Parameters in the Liver Extract of Infected Mice by Lieshmania donovani

This study was designed to examine the effect of combined drugs (pentostam and allopurinol) 20mg / kg and 20,40,60,80 and 100 mg / kg of the aqueous fruit extract of M. azedarach on infected mice for 10,15, and 20 days to determine their effect on some marker enzymes such as aspartate amino transferase ( AST ) , alanine amino transferase ( ALT ) , alkaline phosphatase ( ALP ) , lactate dehydrogenase ( LDH ) and the biochemical parameters like glucose , cholesterol and total protein, The present result showed a significant decrease of the two enzymes (AST and ALT) and significantly increased in (ALP and LDH) acivity in comparison with the enzyme activities in the liver of non– infected mice (con– ve). Where as the treated mice with 40 – 100mg / kg of aqueous fruit extract of the plant caused elevation in the activity of the (AST and ALT) and declining in (ALP and LDH ) activity when compared with infected non – treated mice ( con+ ve) after 10 ,15 and 20days post infection . The results also showed, non – significant differences in the glucose and cholesterol concentrations in infected mice in comparison with the non – infected mice. The treated mice with 20 mg/ kg pentostam/ allopurinol and 40 – 100 mg / kg of aqueous fruit extract of the plant caused in significant elevation of the glucose and cholesterol concentrations in the liver of infected mice in comparison with (con+ ve) after 10 , 15 and 20 days post treatment , but the infection caused non – significant increased in the total protein in liver of mice in comparison with (con– ve) , the treated mice with 20mg / kg pentostam / allopurinol and 40–100 mg / kg from aqueous fruit extract M.azedarach caused decrease of total protein when compared with (cont+ ve) for 10 , 15 and 20 days post treatment . * Hawler Medical University / College of Medicine / Dep. of Anatomy/ Iraq. ** University of Mosul/ College of Science / Dept. of Biology/ Iraq. *** University of Mosul/ College. of Science / Dept. of Biology/ Iraq.
Analysis of the Spontaneous Conception Outcome in Infertile Women After Four-dimensional Hysterosalpingo-Contrast-Sonography

yu liu Guangdong Second Provincial General Hospital ning zhang Guangdong Second Provincial General Hospital yanni he Guangdong Second Provincial General Hospital https://orcid.org/0000-0002-8323-2979 jiayao shi Guangdong Second Provincial General Hospital meijun zhou Guangdong Second Provincial General Hospital jingjiao xu Guangdong Second Provincial General Hospital Hongmei Liu (  hongmeiliu3@163.com ) Department of Ultrasound, Institute of Ultrasound in Musculoskeletal Sports Medicine, Guangdong Second Provincial General Hospital, Guangzhou, Guangdong, P.R. China Second School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong, P.R. https://orcid.org/0000-0002-06417611
HAND POSTURE COMPARISON IN SYNERGY SPACE

4 In studies of human movement control, an important question is how the central nervous system 5 (CNS) controls movements in the presence of a large number of degrees of freedom (DoFs) at 6 all levels of the control architecture. It is known that CNS groups the multiple DoFs into 7 representative functional units also called synergies for simplification of the task. Hence, 8 comparing two different hand postures in the synergy space, rather than joint angle space may 9 provide insightful information about efforts needed (in terms of synergy components) to 10 transform from one hand posture to another hand posture. Working with synergy space may 11 also provide information about how CNS deals with system with multiple DoFs. We developed 12 an index called posture similarity index (PSI) which measures the similarity of two postures 13 by projecting hand posture from the joint angles into the synergy space. A large value of PSI 14 represents high similarity between postures whereas a lower value represents less similarity 15 between postures. 16 This index uses principle of synergies and nicely captures effort required for kinematic 17 transformation. Using this index as a feature, possible set of representative postures can be 18 identified. The other hand postures can be derived from a possible set of representative postures 19 with relatively less efforts for kinematic transformation. 20
Surface composition and properties of Ganymede : Updates from ground-based observations with the near-infrared imaging spectrometer

Ganymede’s surface exhibits great geological diversity, with old dark terrains, expressed through the surface composition, which is known to be dominated by two constituents: H2O-ice and an unidentified darkening agent. In this paper, new investigations of the composition of Ganymede’s surface at global scale are presented. The analyses are derived from the linear spectral modeling of a high spectral resolution dataset, acquired with the near-infrared (1.40 – 2.50 μm) ground-based integral field spectrometer SINFONI (SINgle Faint Object Near-IR Investigation) of the Very Large Telescope (VLT hereafter) located in Chile. We show that, unlike the neighboring moon Europa, photometric corrections cannot be performed using a simple Lambertian model. However, we find that the OrenNayar (1994) model, generalizing the Lambert’s law for rough surfaces, produces excellent results. Spectral modeling confirms that Ganymede’s surface composition is dominated by H2O-ice, which is predominantly crystalline, as well as a darkening agent, but it also clearly highlights the necessity of secondary species to better fit the measurements: sulfuric acid hydrate and salts, likely sulfates and chlorinated. A latitudinal gradient and a hemispherical dichotomy are the strongest spatial patterns observed for the darkening agent, the H2O-ice, and the sulfuric acid: the darkening agent is by far the major compound at the equator and mid-latitudes (≤ ± 35°N), especially on the trailing hemisphere, while the H2O-ice and the sulfuric acid are mostly located at high latitudes and on the leading hemisphere. This anti-correlation is likely a consequence of the bombardment of the constituents in the Jovian magnetosphere which are much more intense at latitudes higher than ± 35°N. Furthermore, the modeling confirms that polar caps are enriched in small, fresh, H2O-ice grains (i.e. ≤ 50 μm) while equatorial regions are mostly composed of larger grains (i.e. ≥ 200 μm, up to 1 mm). Finally, the spatial distribution of the salts is neither related to the Jovian magnetospheric bombardment nor the craters. These species are mostly detected on bright grooved terrains surrounding darker areas. Endogenous processes, such as freezing of upwelling fluids going through the ice shell, may explain this distribution. In addition, a small spectral residue that might be related to brines and/or hydrated silica-bearing minerals are located in the same areas.
Upregulation of long non-coding RNA FOXP4-AS1 and its regulatory network in hepatocellular carcinoma

Objective: FOXP4-AS1 (FOXP4 antisense RNA 1) is putatively a functional oncogene in colorectal cancer. This study constructed a regulatory network involving FOXP4-AS1 for better understanding of its function in hepatocellular carcinoma (HCC). Methods: FOXP4-AS1 was assessed in HCC and adjacent normal (control) liver samples via quantitative real-time PCR. Differentially expressed micro RNAs (DEmiRNAs) were predicted. Their target genes were veri ﬁ ed via the gene expression pro ﬁ ling interaction analysis (GEPIA) database, and subjected to gene ontology (GO) annotation and KEGG (Kyoto Encyclopedia of Genes and Genome) pathway enrichment analysis. Protein-protein interaction (PPI) networks were established and hub genes identi ﬁ ed with Cytoscape software. The GEPIA database was used to assess the prognostic roles of 20 hub genes in liver cancer. The cBioPortal database was used to exhibit alterations of the genes. Results: The HCC samples had signi ﬁ cantly higher levels of FOXP4-AS1 compared with the control ( P =0.001). Six upregulated and 4 downregulated DEmiRNAs were identi ﬁ ed. Over- and under-expressed predicted target genes (183 and 147, respectively) were selected for GO annotation and KEGG pathway enrichment analysis. The downregulated genes were signi ﬁ cantly prominent in the PI3K-Akt signaling pathway; the upregulated genes in the cell cycle. The PPI networks indicated IGFBP3 and PRC1 as hub genes with the highest node degrees. Higher expressions of 9 (6) genes were associated with worse (better) prognosis in HCC. Conclusion: An HCC-associated FOXP4-AS1-miRNA-mRNA regulatory network was constructed, and molecular mechanisms involved in HCC development were elucidated. This work provides direction for ﬁ nding new HCC therapeutic targets.
Comparative Effects of Dand L-3 , 5 , 3 '-Triiodothyronine in Chronic Treatment of Hypercholesteremic Dogs

NATURALLY occurring thyroid hormones and a number of synthetic thyromiinetic analogs have been shown to influence serumlipid levels in man and in laboratory animals. " Chaikoff et al. and Danowski and coworkers have observed that the serum lipids of the dog are significantly altered by the level of circulating thyroid hormone. Although the dog is less dependent on thyroid hormone for control of metabolic processes than is man, its serum cholesterol and other circulating lipids can be markedly altered by the administration of thyromimetie agents. This experiment was designed to measure the relative effectiveness of the chronic oral administration of Dand L-3,5,3'-triiodothyronine on the cireulating-lipid patterns of intact, naturally hypereholesteremic dogs.
ON COMPLETE GRADIENT SHRINKING

In this paper we derive optimal growth estimates on the potential functions of complete noncompact shrinking solitons. Based on this, we prove that a complete noncompact gradient shrinking Ricci soliton has at most Euclidean volume growth. This latter result can be viewed as an analog of the well-known volume comparison theorem of Bishop that a complete noncompact Riemannian manifold with nonnegative Ricci curvature has at most Euclidean volume growth. 1. The results A complete Riemannian metric gij on a smooth manifold M n is called a gradient shrinking Ricci soliton if there exists a smooth function f on M such that the Ricci tensor Rij of the metric gij is given by Rij +∇i∇jf = ρgij for some positive constant ρ > 0. The function f is called a potential function of the shrinking soliton. Note that by scaling gij one can normalize ρ = 1 2 so that Rij +∇i∇jf = 1 2 gij . (1.1) Gradient shrinking Ricci solitons play an important role in Hamilton’s Ricci flow as they correspond to self-similar solutions, and often arise as Type I singularity models. In this paper, we investigate the asymptotic behavior of potential functions and volume growth rates of complete noncompact gradient shrinking solitons. Our main results are: Theorem 1.1. Let (M, gij , f) be a complete noncompact gradient shrinking Ricci soliton satisfying (1.1). Then the potential function f satisfies the estimates 1 4 (r(x)− c1) ≤ f(x) ≤ 1 4 (r(x) + c2) . Received 10/06/2009.
Analysis of the baseline survey on the prevalence of Listeria monocytogenes in certain ready‐to‐eat foods in the EU, 2010–2011 Part B: analysis of factors related to prevalence and exploring compliance

A European Union-wide baseline survey on Listeria monocytogenes was carried out in 2010 and 2011. Packaged (not frozen) hot or cold smoked or gravad fish, soft or semi-soft cheeses (excluding fresh cheeses) and packaged heat-treated meat products were sampled in 26 European Union Member States and in one country not belonging to the European Union. Multiple-factor analysis (Generalized Estimating Equations) was used to investigate the statistical association between several factors on which information was gathered during the baseline survey, and two outcomes: prevalence of Listeria monocytogenes and proportion of samples with counts exceeding 100 cfu/g, in the surveyed fish and meat products (no analysis is presented for cheese samples, owing to the small number of contaminated samples). Sparseness issues led to instability of the effect estimates for some of the factors. For fish samples, factors that exhibited a stable association with at least one of the two outcomes were ̳Subtype of the fish product‘ (factor related to the type of processing), ̳Number of antimicrobial preservatives and/or acidity regulators‘ and ̳Possible slicing‘. For meat products, the corresponding factors were ̳Type of the meat product‘, ̳Animal species of the origin of the meat product‘, ̳Possible slicing‘ and ̳Remaining shelf-life‘ (days between sampling and ̳Use by date‘). Furthermore, a statistical model was developed that allowed the use of estimates of the proportion of samples with an L. monocytogenes count > 100 cfu/g obtained from a single-unit sample survey of a population of RTE foods, in order to estimate the probability that if a five-unit sample had been taken from the same population, no individual unit, out of n = 5 units constituting the sample, would have exceeded the level of 100 cfu/g. The model was applied using data from the baseline survey for fish, cheese and meat products, at the end of shelf-life. © European Food Safety Authority, 2014