Miracle-dz/UniFAR-FTUs huggingface dataset:
Double sequential external defibrillation versus standard defibrillation in refractory ventricular fibrillation: A systematic review and meta-analysis

Introduction Double sequential external defibrillation (DSED) in cardiopulmonary resuscitation has shown different results in comparison with standard defibrillation in the treatment of refractory ventricular fibrillation (RVF). This review aims to compare the advantages of DSED with standard defibrillation in the treatment of refractory ventricular fibrillation. Materials and methods PubMed, Embase, Web of Science, and Cochrane Library were searched from inception to May 1, 2022. Studies included adult patients who developed RVF. The study used random-effects and fixed-effects models for meta-analysis, which was reported by risk ratio (RR) with 95% confidence interval (CI), mean difference (MD), or standardized mean difference (SMD). The risk of bias in individual studies was assessed using the Robins-I tool for observational studies and the Cochrane Risk of Bias 2 (ROB-2) tool for clinical trials. Primary outcomes included the termination of RVF, prehospital return of spontaneous circulation (ROSC), survival to hospital admission, survival to hospital discharge, and good neurological recovery. Secondary outcomes included age, total defibrillation attempts, emergency medical system arrival time, and dose of epinephrine and amiodarone used. Results In this systematic review and meta-analysis, 10 studies containing 1347 patients with available data on treatment outcomes were included. The pooled estimate was (RR 1.03, 95% CI, 0.89 to 1.19; Z = 0.42, P = 0.678 > 0.05) for Termination of RVF, (RR 0.84, 95% CI, 0.63 to 1.11; Z = 1.23, P = 0.219 > 0.05) for ROSC, (RR 0.86, 95% CI, 0.69 to 1.06; Z = 1.4, P = 0.162 > 0.05) for survival to hospital admission, (RR 0.77, 95%CI, 0.52 to 1.15; Z = 1.26, P = 0.206 > 0.05) for survival to hospital discharge, (RR 0.65, 95%CI, 0.35 to 1.22; Z = 1.33, P = 0.184 > 0.05) for good neurologic recovery, (MD −1.01, 95%CI, −3.07 to 1.06; Z = 0.96, P = 0.34 > 0.05) for age, (MD 2.27, 95%CI, 1.80 to 2.73; Z = 9.50, P = 0.001 < 0.05) for total defibrillation attempts, (MD 1.10, 95%CI, −0.45 to 66; Z = 1.39, P = 0.16 > 0.05) for emergency medical system arrival time, (SMD 0.34, 95%CI, 0.17 to 0.50; Z = 4.04, P = 0.001 < 0.05) for epinephrine, and (SMD −0.30, 95%CI, −0.65 to −0.05; Z = 1.66, P = 0.1 > 0.05) for amiodarone. Conclusion We discovered no differences between DSED and standard defibrillation in termination of RVF, prehospital return of spontaneous circulation, survival to hospital admission, survival to hospital discharge, good neurological outcome, emergency medical system arrival time, and amiodarone doses in patients with RVF. There were some differences in the number of defibrillations and epinephrine doses utilized during resuscitation. Systematic review registration [https://www.crd. york.ac. uk/prospero/display_record. php? RecordID=329354], identifier [CRD42022329354].
CEOs' early-life disaster experience and corporate earnings quality: Focusing on the Great Chinese Famine

This paper aims to examine the impact of CEOs' early-life disaster experiences on corporate earnings quality. We proxy the disaster experience with whether CEOs lived through the Great Chinese Famine and the famine intensity they experienced. The results indicate that CEOs' early-life famine experience is significantly positively associated with corporate earnings quality, and the famine effects are more obvious for CEOs who experienced the famine at adolescent ages. Further tests show that the famine experience effects are more pronounced in companies with high investor protection and cross-listing and with CEOs who have a relatively high level of education or background in economic management. The findings suggest CEOs would bear the imprint of an adverse early-life experience, which has risk aversion and learning effects on their decision making in corporate earnings information disclosure.
The transcriptomic landscape of elderly acute myeloid leukemia identifies B7H3 and BANP as a favorable signature in high-risk patients

Acute myeloid leukemia (AML) in the elderly remains a clinical challenge, with a five-year overall survival rate below 10%. The current ELN 2017 genetic risk classification considers cytogenetic and mutational characteristics to stratify fit AML patients into different prognostic groups. However, this classification is not validated for elderly patients treated with a non-intensive approach, and its performance may be suboptimal in this context. Indeed, the transcriptomic landscape of AML in the elderly has been less explored and it might help stratify this group of patients. In the current study, we analyzed the transcriptome of 224 AML patients > 65 years-old at diagnosis treated in the Spanish PETHEMA-FLUGAZA clinical trial in order to identify new prognostic biomarkers in this population. We identified a specific transcriptomic signature for high-risk patients with mutated TP53 or complex karyotype, revealing that low expression of B7H3 gene with high expression of BANP gene identifies a subset of high-risk AML patients surviving more than 12 months. This result was further validated in the BEAT AML cohort. This unique signature highlights the potential of transcriptomics to identify prognostic biomarkers in in elderly AML.
Impact of multiple drug-resistant Gram-negative bacterial bacteraemia on infected pancreatic necrosis patients

Introduction Multiple drug-resistant Gram-negative bacterial (MDR-GNB) bacteraemia poses a serious threat to patients in hospital. Infected pancreatic necrosis (IPN) patients are a vulnerable population to infectious complications during hospitalization. This study aims to evaluate the impact of MDR Gram-negative bacteraemia on IPN patients. Methods A case–control study was performed with data collected from 1 January 2016 to 1 July 2022 in a Chinese tertiary teaching hospital. Clinical data of the IPN patients with MDR-GNB bacteraemia were analyzed and compared to those of a matched control group without MDR-GNB bacteraemia (case–control ratio of 1:2). Comparisons were performed between with/without MDR-GNB bacteraemia and different severities of acute pancreatitis (AP). Independent predictors of overall mortality were identified via univariate and multivariate binary logistic regression analyses. Results MDR-GNB bacteraemia was related to a higher mortality rate (62.5% vs. 8.3%, p < 0.001). Severe AP combined with MDR-GNB bacteraemia further increased mortality up to 81.3% (p = 0.025). MDR-GNB bacteraemia (odds ratio (OR) = 8.976, 95% confidence interval (CI) = 1.805 –44.620, p = 0.007) and severe AP (OR = 9.414, 95% CI = 1.742 –50.873, p = 0.009) were independent predictors of overall mortality. MDR- Klebsiella pneumoniae was the most common causative pathogen. Conclusion A higher mortality rate in IPN patients was related to MDR-GNB bacteraemia and further increased in severe AP patients combined with MDR-GNB bacteraemia.
Ontogenetic development of inner ear hair cell organization in the New Zealand carpet shark Cephaloscyllium isabellum

Introduction The inner ear hair cells of fishes can provide insight into the early evolution of vertebrate inner ear structure. Fishes represent some of the first vertebrates to evolve auditory capacity, and the same basic structure, the sensory hair cell, provides the fundament for auditory and vestibular function in jawed vertebrates. Despite holding critical basal position in the evolutionary tree of gnathostomes, relatively little is known about inner ear hair cells in elasmobranchs. Specifically, the extent of plasticity in hair cell organization throughout ontogeny among different sensory epithelia and the degree of variation between species is unknown. Methods In this study, we characterized the inner ear hair cells of the New Zealand carpet shark Cephaloscyllium isabellum throughout ontogeny by quantifying macular area, number of hair cells, hair cell density, and hair cell orientations in the inner ear maculae from a range of body sizes. Results Similar to other elasmobranchs and bony fishes, macular area and the number of hair cells increased throughout ontogeny in the otolith organs. The orientations of hair cells within each maculae also was consistent with the limited data on other elasmobranchs. However, contrary to expectation, the macula neglecta did not increase in area or hair cell number throughout ontogeny, and hair cell density did not change with body size in any maculae. Discussion These findings suggest there may be variation between elasmobranch species in ontogenetic development of hair cell organization that may be related to hearing capabilities throughout life.
The exact dynamical Chern–Simons metric for a spinning black hole possesses a fourth constant of motion: a dynamical-systems-based conjecture

The recent gravitational wave observations by the LIGO/Virgo collaboration have allowed the first tests of general relativity in the extreme gravity regime, when comparable-mass black holes and neutron stars collide. Future space-based detectors, such as the Laser Interferometer Space Antenna, will allow tests of Einstein’s theory with gravitational waves emitted when a small black hole falls into a supermassive one in an extreme mass-ratio inspiral. One particular test that is tailor-made for such inspirals is the search for chaos in extreme gravity. We here study whether chaos is present in the motion of test particles around spinning black holes of parity-violating modified gravity, focusing in particular on dynamical Chern–Simons gravity. We develop a resummation strategy that restores all spin terms in the general relativity limit, while retaining up to fifth-order-in-spin terms in the dynamical Chern–Simons corrections to the Kerr metric. We then calculate Poincaré surfaces of section and rotation numbers of a wide family of geodesics of this resummed metric. We find evidence for geodesic chaos, portrayed by thin chaotic layers surrounded by deformed invariant tori. This chaotic layers shrink in size as terms of higher-order in spin are included in the dynamical Chern–Simons corrections to the Kerr metric. Our numerical findings suggest that the geodesics of the as-of-yet unknown exact solution for spinning black holes in this theory may be integrable, and that there may thus exist a fourth integral of motion associated with this exact solution. The studies presented here begin to lay the foundations for chaotic tests of general relativity with the observation of extreme mass ratio inspirals with the Laser Interferometer Space Antenna.
The human cytomegalovirus decathlon: Ten critical replication events provide opportunities for restriction

Human cytomegalovirus (HCMV) is a ubiquitous human pathogen that can cause severe disease in immunocompromised individuals, transplant recipients, and to the developing foetus during pregnancy. There is no protective vaccine currently available, and with only a limited number of antiviral drug options, resistant strains are constantly emerging. Successful completion of HCMV replication is an elegant feat from a molecular perspective, with both host and viral processes required at various stages. Remarkably, HCMV and other herpesviruses have protracted replication cycles, large genomes, complex virion structure and complicated nuclear and cytoplasmic replication events. In this review, we outline the 10 essential stages the virus must navigate to successfully complete replication. As each individual event along the replication continuum poses as a potential barrier for restriction, these essential checkpoints represent potential targets for antiviral development.
Exploring agency and entrainment in joint music-making through the reported experiences of students and teachers

This qualitative interview-based study draws on the reported experiences of students and teachers to explore how agency and entrainment resource and constrain each other in joint music-making. The participants were 23 students of Grades 6 and 11 music teachers from different primary schools. The qualitative content analysis of the 11 student pair interviews and 11 one-to-one teacher interviews indicated that experiences of music-related interpersonal entrainment intertwine with different dimensions of agency. In the analysis, four themes were identified as follows: presence, belonging, safety, and continuity. These findings provide insights into the relationship between agency and entrainment in classroom-based joint music-making and provide a novel lens through which to examine the complementary experiences of students and teachers. This study builds bridges between the concepts of agency and entrainment in the context of music education, offering theoretical clarification as to how and why joint music-making can be considered an intersubjective activity that fosters group cohesion and social interaction. The findings further present a view of the constitutive nature of the relationship among agency, entrainment, and intersubjectivity in joint music-making. The findings offer educators concrete grounds for using joint music-making as a platform for an agency.
Cardiovascular autonomic modulation differences between moderate-intensity continuous and high-intensity interval aerobic training in women with PCOS: A randomized trial

Background Moderate-intensity continuous training (MICT) is strongly recommended for polycystic ovarian syndrome (PCOS) treatment. However, recent studies have suggested that high-intensity interval training (HIIT) would promote great benefits for cardiac autonomic control. Therefore, we investigated whether the benefits of HIIT related to cardiovascular autonomic control were greater than those of MICT in women with PCOS. Methods Women with PCOS were randomly allocated through a blind draw into three groups: control, MICT, and HIIT. The control group did not undergo exercise, whereas those in the MICT and HIIT groups underwent 16 weeks of aerobic physical training. All groups were evaluated before and after the 16 weeks of intervention in the following aspects: quantification of serum lipids, testosterone, fasting insulin and blood glucose; physical fitness through cardiopulmonary testing; analysis of heart rate variability (HRV) by linear (time domain and frequency domain) and non-linear (symbolic analysis) methods, analysis of blood pressure variability (BPV) and spontaneous baroreflex sensitivity (BRS). Results The final analysis, each group comprised 25 individuals. All groups had similar baseline parameters. After 16 weeks, intragroup comparison showed that the MICT and HIIT groups had a reduction in baseline heart rate (P < 0.001; P < 0.001, respectively) and testosterone levels P < 0.037; P < 0.012, respectively) associated with an increase in VO2peak (MICT, P < 0.001; HIIT, P < 0.001). The MICT (P < 0.36) and HIIT (P < 0.17) groups also showed an increase in cardiac vagal modulation, however only observed in the non-linear analysis. The intergroup comparison showed no differences between the MICT and HIIT groups in any of the hormonal, metabolic and autonomic parameters evaluated, including testosterone, peak oxygen uptake (VO2peak), HRV, BPV and BRS. Conclusion HIIT and MICT showed similar results for the different parameters evaluated. This suggests that both training protocols can be recommended for the treatment of PCOS. Brazilian Clinical Trials Registry (RBR-78qtwy).
The Umbral Moonshine Module for the Unique Unimodular Niemeier Root System

We use canonically-twisted modules for a certain super vertex operator algebra to construct the umbral moonshine module for the unique Niemeier lattice that coincides with its root sublattice. In particular, we give explicit expressions for the vector-valued mock modular forms attached to automorphisms of this lattice by umbral moonshine. We also characterize the vector-valued mock modular forms arising, in which four of Ramanujan's fifth order mock theta functions appear as components.
Quantifying the Severity of Metopic Craniosynostosis Using Unsupervised Machine Learning

Background: Quantifying the severity of head shape deformity and establishing a threshold for operative intervention remains challenging in patients with metopic craniosynostosis (MCS). This study combines three-dimensional skull shape analysis with an unsupervised machine-learning algorithm to generate a quantitative shape severity score (cranial morphology deviation) and provide an operative threshold score. Methods: Head computed tomography scans from subjects with MCS and normal controls (5 to 15 months of age) were used for objective three-dimensional shape analysis using ShapeWorks software and in a survey for craniofacial surgeons to rate head-shape deformity and report whether they would offer surgical correction based on head shape alone. An unsupervised machine-learning algorithm was developed to quantify the degree of shape abnormality of MCS skulls compared to controls. Results: One hundred twenty-four computed tomography scans were used to develop the model; 50 (24% MCS, 76% controls) were rated by 36 craniofacial surgeons, with an average of 20.8 ratings per skull. The interrater reliability was high (intraclass correlation coefficient, 0.988). The algorithm performed accurately and correlates closely with the surgeons assigned severity ratings (Spearman correlation coefficient, r = 0.817). The median cranial morphology deviation for affected skulls was 155.0 (interquartile range, 136.4 to 194.6; maximum, 231.3). Skulls with ratings of 150.2 or higher were very likely to be offered surgery by the experts in this study. Conclusions: This study describes a novel metric to quantify the head shape deformity associated with MCS and contextualizes the results using clinical assessments of head shapes by craniofacial experts. This metric may be useful in supporting clinical decision making around operative intervention and in describing outcomes and comparing patient population across centers.
Periodic structure of translational multi-tilings in the plane

abstract:Suppose $f\in L^1(\Bbb{R}^d)$, $\Lambda\subset\Bbb{R}^d$ is a finite union of translated lattices such that $f+\Lambda$ tiles with a weight. We prove that there exists a lattice $L\subset\Bbb{R}^d$ such that $f+L$ also tiles, with a possibly different weight. As a corollary, together with a result of Kolountzakis, it implies that any convex polygon that multi-tiles the plane by translations admits a lattice multi-tiling, of a possibly different multiplicity.Our second result is a new characterization of convex polygons that multi-tile the plane by translations. It also provides a very efficient criteria to determine whether a convex polygon admits translational multi-tilings. As an application, one can easily construct symmetric $(2m)$-gons, for any $m\geq 4$, that do not multi-tile by translations.Finally, we prove a convex polygon which is not a parallelogram only admits periodic multiple tilings, if any.
Chemical composition of four forage grasses from the state of Jalisco

In the Mexican tropics, livestock farming is based on extensive production systems, and it is important to know the nutritional content of forages, therefore the objective of this study was to evaluate the chemical composition of: Cenchrus ciliaris L. , Megathyrsus maximus cv Guinea, Ixophorus unisetus and Megathyrsus maximus cv Tanzania, grasses established and frequently used in the Tropics for animal feed. The samples from the locality ‘San Luis Tenango’, Tonaya, Jalisco were analyzed at the Laboratory of Animal Nutrition, Department of Zootechnics, Chapingo Autonomous University. The following was determined: ashes (Ash), crude protein (CP), ethereal extract (EE), neutral detergent fiber (NDF), cellular content (CC), acid detergent fiber (ADF) and cellulose (Cel). Data analysis was performed with three repetitions and each repetition was considered an experimental unit. Pearson’s correlation and the separation of means by Tukey (p < 0.05) were performed. CP was positively correlated with Ash and CC and negatively correlated with NDF and ADF ( p < 0.05). Megathyrsus maximus cv Guinea was the forage species with the highest amount of CP (12.9 g (100 g) -1 ), followed by ( p < 0.05) Megathyrsus maximus cv Tanzania (8.7 g (100 g) -1 ). Megathyrsus maximus cv Guinea showed the highest percentage of Ash, 11.7 g (100 g) -1 and the lowest values of ADF and Cel and its NDF value (74.8 g (100 g) -1 ) was low ( p < 0.05), slightly higher than that of Ixophorus unisetus (73.5 g (100 g) -1 ). Therefore, Megathyrsus maximus cv Guinea was the grass with the highest nutritional value.
Strong convergence rates and temporal regularity for Cox-Ingersoll-Ross processes and Bessel processes with accessible boundaries

Cox-Ingersoll-Ross (CIR) processes are widely used in financial modeling such as in the Heston model for the approximative pricing of financial derivatives. Moreover, CIR processes are mathematically interesting due to the irregular square root function in the diffusion coefficient. In the literature, positive strong convergence rates for numerical approximations of CIR processes have been established in the case of an inaccessible boundary point. Since calibrations of the Heston model frequently result in parameters such that the boundary is accessible, we focus on this interesting case. Our main result shows for every $p \in (0, \infty)$ that the drift-implicit square-root Euler approximations proposed in Alfonsi (2005) converge in the strong $L^p$-distance with a positive rate for half of the parameter regime in which the boundary point is accessible. A key step in our proof is temporal regularity of Bessel processes. More precisely, we prove for every $p \in (0, \infty)$ that Bessel processes are temporally $1/2$-H\"older continuous in $L^p$.
Local well-posedness for the periodic mKdV in $H^{1/4+}$

We study the mKdV equation with periodic boundary conditions. We establish low regularity well -posedness in $H^{\frac{1}{4}+}(T)$. The proof involves a non-linear, solution dependent gauge transformation, similar to the one considered in Nakanishi-Takaoka-Tsutsumi.
Non-Kahler heterotic rotations

We study a supersymmetry-preserving solution-generating method in heterotic supergravity. In particular, we use this method to construct one-parameter non-Kahler deformations of Calabi-Yau manifolds with a U(1) isometry, in which the complex structure remains invariant. We explain how to obtain corresponding solutions to heterotic string theory, up to first order in \alpha', by a modified form of the standard embedding. In the course of the paper we also show that Abelian heterotic supergravity embeds into type II supergravity, and note that the solution-generating method in this context is related to a dipole-type deformation when there is a field theory dual.
Linear Quadratic Mean Field Game with Control Input Constraint

In this paper, we study a class of linear-quadratic (LQ) mean-field games in which the individual control process is constrained in a closed convex subset $\Gamma$ of full space $\mathbb{R}^m$. The decentralized strategies and consistency condition are represented by a class of mean-field forward-backward stochastic differential equation (MF-FBSDE) with projection operators on $\Gamma$. The wellposedness of consistency condition system is obtained using the monotonicity condition method. The related $\epsilon$-Nash equilibrium property is also verified.
Arecibo H I data for 136 spiral galaxies

On presente les resultats d'observations de l'emission HI de 136 galaxies spirales. La plupart des 114 objets detectes ont ete cartographies suivant l'axe principal et on presente les spectres cumulatifs et les cartes de contour pour chacun d'entre eux. On en deduit le contenu en HI, la vitesse, les largeurs de raies et les diametres HI. On presente egalement les donnees sous forme tabulaire pour chacune des positions observees