Miracle-dz/UniFAR-FTUs huggingface dataset:
A Comprehensive Genome-Wide Investigation of the Cytochrome 71 (OsCYP71) Gene Family: Revealing the Impact of Promoter and Gene Variants (Ser33Leu) of OsCYP71P6 on Yield-Related Traits in Indica Rice (Oryza sativa L.)

The cytochrome P450 (CYP450) gene family plays a critical role in plant growth and developmental processes, nutrition, and detoxification of xenobiotics in plants. In the present research, a comprehensive set of 105 OsCYP71 family genes was pinpointed within the genome of indica rice. These genes were categorized into twelve distinct subfamilies, where members within the same subgroup exhibited comparable gene structures and conserved motifs. In addition, 105 OsCYP71 genes were distributed across 11 chromosomes, and 36 pairs of OsCYP71 involved in gene duplication events. Within the promoter region of OsCYP71, there exists an extensive array of cis-elements that are associated with light responsiveness, hormonal regulation, and stress-related signaling. Further, transcriptome profiling revealed that a majority of the genes exhibited responsiveness to hormones and were activated across diverse tissues and developmental stages in rice. The OsCYP71P6 gene is involved in insect resistance, senescence, and yield-related traits in rice. Hence, understanding the association between OsCYP71P6 genetic variants and yield-related traits in rice varieties could provide novel insights for rice improvement. Through the utilization of linear regression models, a total of eight promoters were identified, and a specific gene variant (Ser33Leu) within OsCYP71P6 was found to be linked to spikelet fertility. Additionally, different alleles of the OsCYP71P6 gene identified through in/dels polymorphism in 131 rice varieties were validated for their allelic effects on yield-related traits. Furthermore, the single-plant yield, spikelet number, panicle length, panicle weight, and unfilled grain per panicle for the OsCYP71P6-1 promoter insertion variant were found to contribute 20.19%, 13.65%, 5.637%, 8.79%, and 36.86% more than the deletion variant, respectively. These findings establish a robust groundwork for delving deeper into the functions of OsCYP71-family genes across a range of biological processes. Moreover, these findings provide evidence that allelic variation in the promoter and amino acid substitution of Ser33Leu in the OsCYP71P6 gene could potentially impact traits related to rice yield. Therefore, the identified promoter variants in the OsCYP71P6 gene could be harnessed to amplify rice yields.
PENENTUAN FORMULASI OPTIMUM PEMBUATAN COOKIES DARI BEKATUL PADI PANDANWANGI DENGAN PENAMBAHAN TEPUNG TERIGU MENGGUNAKAN METODE RSM (Response Surface Method)

Bekatul merupakan hasil limbah dari padi yang berpotensi untuk dapat dimanfaatkan menjadi produk pangan. Maka dari itu melihat hal tersebut kiranya dapat dibuat sebuah produk yang praktis, mudah dikonsumsi dan banyak diminati dalam bentuk biskuit yang berasal dari proses penambahan bekatul yang dicampur dengan tepung terigu, telur, gula dan margarine. Penelitian ini difokuskan untuk mengetahui pengaruh formulasi bekatul dengan tepung terigu terhadap mutu organoleptik cookies bekatul serta mengetahui respon optimum uji organoleptik cookies bekatul sebagai produk diversifikasi pangan. Data diolah menggunakan metode RSM (Response Surface Method) dengan melibatkan 25 panelis biasa dan 1 orang panelis ahli dengan parameter uji yang dilakukan yaitu meliputi tekstur, warna, aroma dan rasa. Masing-masing panelis diberikan 4 sampel berbeda pada setiap formulasinya. Karakteristik untuk warna dan aroma yang diminati oleh panelis yaitu sampel F4 (Bekatul 40% + Tepung terigu 60%) dengan nilai optimasi warna 1 sedangkan nilai optimasi aroma 3. Sementara untuk parameter sampel tekstur dan rasa yang diminati oleh panelis adalah sampel F2 (Bekatul 60% + Tepung terigu 40%) dengan nilai optimasi yaitu 1.
Role of the gut microbiota in hematologic cancer

Hematologic neoplasms represent 6.5% of all cancers worldwide. They are characterized by the uncontrolled growth of hematopoietic and lymphoid cells and a decreased immune system efficacy. Pathological conditions in hematologic cancer could disrupt the balance of the gut microbiota, potentially promoting the proliferation of opportunistic pathogens. In this review, we highlight studies that analyzed and described the role of gut microbiota in different types of hematologic diseases. For instance, myeloma is often associated with Pseudomonas aeruginosa and Clostridium leptum, while in leukemias, Streptococcus is the most common genus, and Lachnospiraceae and Ruminococcaceae are less prevalent. Lymphoma exhibits a moderate reduction in microbiota diversity. Moreover, certain factors such as delivery mode, diet, and other environmental factors can alter the diversity of the microbiota, leading to dysbiosis. This dysbiosis may inhibit the immune response and increase susceptibility to cancer. A comprehensive analysis of microbiota-cancer interactions may be useful for disease management and provide valuable information on host-microbiota dynamics, as well as the possible use of microbiota as a distinguishable marker for cancer progression.
Formulation and characterization of micro-emulsions of peppermint and coriander oils extracted by using a supercritical fluid system

ABSTRACT The present study was designed to formulate and characterize the micro-emulsions of peppermint and coriander oil that extracted by using supercritical fluid extraction system. Moreover, Guar gum and maltodextrin were used as coating materials while preparing encapsulates of peppermint and coriander through freeze-drying. The moisture contents of mint leaves and coriander were 81.28 ± 7.12 and 84.62 ± 6.46% respectively whereas the recorded protein content in mint and coriander leaves were 1.456 ± 0.13 and 5.06 ± 0.03% respectively. The crude fat was high in mint leaves as compared to coriander. However, the ash content was 2.98 ± 0.278 in mint and 2.8 ± 0.12 in coriander leaves. The total phenolic contents (TPC) and antioxidant activity coriander essential oil was high as compared to peppermint oil. The results showed the better antioxidant activity of coriander than peppermint. Encapsulation efficiency of powder showed significant results of wall material. T3 (maltodextrin and coriander oil) exhibited better binding capability of bioactive components as compared to guar gum and mint. T3 was coriander and maltodextrin better ability to inhibit the oxidation process and had good DPPH assays as compared to other treatments. This study showed that the T3 (maltodextrin and coriander oil) exhibited better binding capability of bioactive components as compared to guar gum and mint. T3 was (coriander and maltodextrin) better ability to inhibit the oxidation process and had good DPPH assays to other treatments.
Perceived Teacher Confirmation and the Online Classroom: Capturing Student Descriptions of Experiences with Faculty Online

This study explored and examined students’ perceptions of teacher confirmation, those behaviors that teachers engage in that make students feel confirmed as valuable, significant individuals, as experienced in online courses. With over 450 students’ written descriptions of experiences in online classes across three different universities, this study provides an important initial examination of teaching practices in the online context. While prior research has situated study of students’ perceptions of teacher confirmation in the traditional in-person course experience, the current project extends understanding of teacher confirmation into the online setting. The study provides detailed descriptions, in students’ own words, of specific tactics instructors can use and avoid in order to promote feelings of confirmation in their students.
Contributions of Africa to management and organization science

ABSTRACT Given the increasing globalization of management and organization science (MOS), it has been suggested that scholarly communities examine the contributions of their contexts to the discipline. Accordingly, the contributions from Africa to MOS across the pre-modern, modern, and post-modern eras are examined using generative theory. Evidence from historical, philosophical, anthropological, and sociological sources demonstrates that significant contributions to MOS have originated from Africa. Even so, those contributions have not been acknowledged, especially in the post-modern era, due to the “writing out” of Africa. Several implications for research and pedagogy concerning MOS and Africa are considered given the current trend of decolonization.
Assessment of prevalence and pattern of comorbidities in hospitalized patients with uncontrolled hyperglycemia in Western Odisha

Diabetes, especially type 2 diabetes, is one of the main global health problems and accounts for the highest morbidity and mortality worldwide. Due to its significant impacts on human life in terms of morbidity and health expenditures, diabetes has become a major public health concern worldwide. Apart from microvascular and macrovascular complications, other comorbidities found frequently in patients with diabetes are hypertension, obesity, chronic kidney disease, stroke, coronary heart disease, hypothyroidism, rheumatoid arthritis, chronic pulmonary disease and cancer. This was a hospital-based cross-sectional study to assess comorbidities in indoor patients of the Department of Medicine. All patients admitted with a history of diabetes or newly detected diabetes were identified, and relevant information was collected in a predesigned and pretested questionnaire. A total of 320 patients were assessed during the study period, of whom 52% were males and 48% were females. Most patients were in the age group of 51-60, followed by the 61-70 and 41-50 age groups. Hypertension was the most prevalent comorbidity, followed by dyslipidemia and chronic kidney disease. Approximately 42% of patients had one comorbidity, and 37% had two comorbidities simultaneously. The prevalence of comorbidities was higher and glycemic control was more compromised in those who had diabetes for a prolonged period.
Important but challenging: Chinese in-service EFL teachers’ research attitudes in a graduate program

In recent decades, the practice of involving teachers in research in degree programs is becoming popular. Yet, little is known about the impact of research experiences on teachers’ behavior: whether research experiences change their teaching practices and lead to further research efforts in future careers, especially in the unique social, cultural, and educational culture of China. Thus, this study examines Chinese IETs’ (in-service EFL teachers’) research attitudes in a graduate program with a reasoned action approach. We used an embedded mixed methods research design to investigate a cohort of 197 IETs who completed the Research Attitudes in Vocational Education Questionnaire (RAVE-Q). The quantitative data validates the survey and shows that, in general, the IETs hold positive attitudes toward research. Next, semi-structured interviews investigating IETs and their advisors’ perceptions of teacher research were conducted. The qualitative data shows a variety of research experiences among the IETs. Specifically, this study highlighted some interviewed IETs who had the desire to be reflective about their teaching and to apply research in their practices, nevertheless, the educational contexts made such efforts impossible. Thus, this study questioned the previous assumptions that positive research attitudes lead to corresponding research behaviors. This study offers implications for EFL graduate programs seeking to improve IETs’ research attitudes both within and outside China.
Impact of Laboratory Method on Students’ Motivation of Mathematics in Secondary Schools of Kapseret Sub County Kenya

Mathematics is compulsory for all learners in secondary schools, as recommended by the Kenya Institute of Curriculum Development (2010). The performance of mathematics has been consistently low and one of the reasons is insufficient Mathematics laboratory. The study sought to determine Mathematics performance among secondary school students. The study instruments that were used included a pre-test, post-test, non-equivalent group experimental design, questionnaires, and an interview schedule. The researcher sampled 298 students and 26 teachers who took part in the study. The Form two students were selected to participate in the study. A sample size that represented the study population was selected using simple random sampling and purposive sampling while stratified sampling was used to select the schools. The study used the Solomon Four-Group design where two groups were formed, one experimental and one control group. The experimental group entered laboratory instructional strategy method while the control group entered conventional instructional strategy method. The respondents were assigned in their complete classes to four groups; experimental groups 1 and 3, and control groups 2 and 4. All the groups were taught the same content of the reflection and congruence. However, groups 1 and 3 were taught using laboratory method while groups 2 and 4 were taught by conventional methods. Groups 1 and 3 were pre-tested prior to the implementation of the laboratory method treatment. Teachers who took part in the study were inducted prior to the study by the researcher for period of three weeks. Mathematics Achievement Test 1 and Mathematics Achievement Test 2, questionnaires and interviews were used to collect data. SPSS was used to aid in data analysis. Chi-square tests were used to establish relationships. The study findings indicated that the laboratory method arouse the learners’ interest, increased learner participation, boosted the performance, enabled learners to develop the necessary skills for more advanced study research and promoted the development of scientific thinking. The study recommends that there is need for teachers to use laboratory method, which ensures that learners are more involved and engaged more in doing Mathematics activities and teachers have to be trained on the use of such pedagogy.
Effect of Plant Extracts Combinations on TNF-α, IL-6 and IL-10 Levels in Serum of Rats Exposed to Acute and Chronic Stress

Oxydative stress, anxiety and depression are associated with changes in cytokine levels. Natural products, including individual and combined plant extracts, have the potential to be used in the treatment of neuropsychiatric disorders. The goal of this study is to investigate the effects of two combined plant extracts, rich in flavonoids, on the levels of the cytokines TNF-α, IL-6, and IL-10 in rats subjected to models of acute cold stress and chronic unpredictable stress. The study utilized common medicinal plants such as Valeriana officinalis, Melissa officinalis, Crataegus monogyna, Hypericum perforatum, and Serratula coronata, which were combined in two unique combinations—Antistress I and Antistress II. The compositions of the used extracts were determined by HPLC methods. Pro- and anti-inflammatory cytokines in rats’ serum were measured with Enzyme-linked immunosorbent assay. The results from the acute stress model revealed that the individual extract of Crataegus monogyna decreased levels of TNF-α, while Serratula coronata, Hypericum perforatum, and Valeriana officinalis effectively reduced IL-6 levels. Both combinations, Antistress I and Antistress II, were effective in reducing TNF-α and IL-6 levels, with Antistress II also increasing IL-10 levels. In the chronic stress model, Hypericum perforatum extract decreased the levels of the pro-inflammatory cytokines TNF-α and IL-6, whereas extracts of Serratula coronata and Valeriana officinalis only reduced TNF-α levels. The two combined extracts, Antistress I and Antistress II, decreased TNF-α and IL-6 levels, while Antistress I also reduced the levels of the anti-inflammatory cytokine IL-10. The combinations of plant extracts used in our experiment have not been previously studied or documented in the available literature. However, based on our own experimental results, we can draw the conclusion that the combinations exhibit a more pronounced effect in reducing cytokine levels compared to the individual plant extracts.
The Prevalence of Irritable Bowel Syndrome and Its Co-existence With Migraine in Medical and Non-medical Students at Al-Baha University, Saudi Arabia

Background: It was hypothesized that the prevalence of irritable bowel syndrome (IBS) and migraine and their co-existence are higher among medical students. In this study, we aim to establish the prevalence of IBS and migraine in the medical and non-medical students at Al-Baha University, Saudi Arabia, and to observe the association and relationship between IBS and migraine using the Rome IV diagnostic criteria for IBS and the International Classification of Headache Disorders (ICHD)-3 criteria for migraine. Methodology: This cross-sectional study was done on the Saudi Arabian campus of Al-Baha University between July 2022 and July 2023. Al-Baha city-dwelling male and female college students aged 18 to 29 comprised the study population. A self-administered electronic questionnaire was sent online to determine the prevalence of IBS and migraine, in addition to associated risk factors. The questionnaire consisted of three sections: demographic and lifestyle data, the Rome IV criteria for diagnosing and subclassifying IBS, and the ICHD-3 criteria for diagnosing migraine. Results: The study was conducted among 452 participants with a mean age of 21.64 years. The majority of participants were not from medical schools. The majority of medical and non-medical participants were male, at 66.6% and 63.1%, respectively. In our study, 36.9% of the individuals reported having a first-degree relative diagnosed with IBS, whereas 2.7% reported having IBS themselves. Regarding migraine, 17.9% of respondents claimed to have a first-degree relative with migraine, while 6.9% of respondents themselves reported experiencing migraine. Regarding IBS prevalence, there was no significant difference between participants from non-MBBS colleges and MBBS colleges. Similarly, there was no significant difference in migraine prevalence between these two groups (92.0% vs. 95.4%, p=0.185). Conclusion: The current study contributes significantly to our understanding of the prevalence of IBS and migraines among medical students, as well as these individuals' demographic characteristics, familial histories, and aggravating variables.
Extraction and Characterization of Cellulose and Microcrystalline Cellulose from Teff Straw and Evaluation of the Microcrystalline Cellulose as Tablet Excipient

ABSTRACT Teff (Eragrostis tef), a grass which belongs to the Family Poaceae, is widely cultivated for its starch-rich grains in Ethiopia, generating large amounts of agricultural byproduct, teff straw. The aim of this study was to isolate and characterize cellulose and microcrystalline cellulose (MCC) from teff straw and evaluate MCC as directly compressible tablet excipient. Cellulose was extracted from teff straw and partially depolymerized to obtain MCC. The physicochemical properties of cellulose and MCC powders were characterized. Yields of cellulose and MCC powder from the raw material were 35.2% and 27.2%, respectively. The samples exhibited type-I crystal lattice and similar infrared spectra with that of Avicel PH-101. The degree of polymerization (DP) and crystallinity index of cellulose were 594.51 and 72.26%, respectively. Whereas, MCC powders showed DP of 241.09–257.38 and crystallinity indexes of 76.45–84.52%. Spray dried MCC was found to be more porous and poorly flowable and had higher moisture content when compared with the oven-dried MCC powder. Tablets prepared from both MCC powders fulfil most of the pharmacopoeial requirements. The spray-dried MCC powder also showed superior compactibility to oven-dried MCC. Teff straw can, therefore, be considered to be an alternative source of cellulose and MCC.
Prevalence and awareness of Herpes Zoster Among Saudi Patients with Diabetes Mellitus, A Cross Sectional Study in Al-Ahsa, Saudi Arabia

Background: Herpes zoster (HZ) is a painful vesicular rash that happens when an infection with the varicella-zoster virus in the sensory ganglia is reactivated. The incidence and severity of HZ and its complications increase with advancing age, with a marked increase after 50 years of age. In addition, diabetes mellitus has been found to be a risk factor for severe, persistent postherpetic neuralgia. Methods: This descriptive cross-sectional hospital-based study was conducted in Al-Ahsa City, Eastern Saudi Arabia, in 2023. The study population included patients with DM who visit outpatient (ambulatory care) in primary or secondary health care setting. The convenience sample included 224 participants. A validated closed-ended interview questionnaire was used to collect data. The collected data were analyzed by the SPSS program version 28, and both descriptive and inferential statistics were used. Results: The study included 224 participants, more than half (54.5%) of whom were female. The mean (SD) age of the sample was 61.1 ± 8 years. Most of the participants (97.8%) were married, and 29.0% had a secondary school education level. More than half of the participants (56.7%) had heard of HZ. Only 6.7% had been diagnosed with HZ, and 23.7% knew someone who had been diagnosed with HZ. In addition, 18.8% had been vaccinated against HZ. Most patients (80.8%) cited healthcare providers as their primary source of HZ knowledge, followed by friends/relatives (37.9%). More than half of the participants were aware of HZ (62.1%) and had a positive attitude towards HZ (55.8%) respectively. Awareness of HZ was positively correlated with a higher level of education, a high income, a short duration of diabetes, having heard of HZ, being diagnosed with HZ, knowing someone who had been diagnosed with HZ, and being vaccinated against HZ among diabetic patients. Conclusion: The results revealed low vaccination rates and low awareness of HZ. The study recommends that education in simple language should be provided through various media to increase community awareness about HZ and its vaccine. Additionally, healthcare providers should promote and recommend HZ vaccinations for DM patients.
Adherence to Iron-Folic Acid Among Pregnant Women Attending Antenatal Care in Southern Ethiopia, 2022

Background: Among the micronutrient deficiencies, iron and folic acid are the most common and frequently occur in pregnant women. So, the objective of this study was to assess the adherence to iron and folic acid among pregnant women booking antenatal services in the study area. Materials and Methods: A facility-based cross-sectional study design was used from January to April 2022. A structured questionnaire was used to collect data using systematic sampling techniques to approach 339 pregnant women. Data were entered and analyzed using SPSS software version 20. A descriptive analysis was performed. Adjusted odds ratios and corresponding 95% confidence intervals (CIs) were used, and statistical significance was reported at p-values <0.05 with 95% confidence. Results: In this study, 339 (99%) pregnant women participated. The mean age of the respondents was 28.04 years old, with a standard deviation of 5.3 years. The rate of adherence to iron and folic acid supplementation (IFAS) in pregnant women was 62.8%. Mothers under 19 years old (adjusted odds ratio [AOR] = 0.025; 95% CI [0.003–0.218]), daily (AOR = 0.127; 95% CI [0.028–0.568]), and those with a history of miscarriage (AOR = 0.276; 95% CI [0.086–0.891]) were less likely to be using IFAS. However, greater knowledge of IFAS was positively correlated with use of the supplements (AOR = 5.56; 95% CI [1.23–8.34]). Conclusions: In this study, the adherence rate with IFAS of pregnant women in the study area was 62.8%. This indicates that one in four women is not in compliance with IFAS. Appropriate counseling and health education should be provided to pregnant women to improve compliance.