Miracle-dz/UniFAR-FTUs huggingface dataset:
Dynamic connectedness and spillovers across sectors: Evidence from the Indian stock market

This paper explores stock market sectoral connectedness for the emerging market economy of India. We use the time-varying parameter vector autoregressive dynamic connectedness of Antonakakis and Gabauer (2017). Results show that the stock market sectoral connectedness varies across time. Connectedness is strongest among sectors during the 2008 crisis, the double-digit inflation and stock market crash of 2011, national elections of 2014, and the historic demonetization of 2016. In addition, consumers’ spending, industry, finance, and basic materials appear to be net transmitters of shocks. By contrast, information technology, fast moving consumer goods, healthcare, and telecommunications are net receivers of shocks. This paper can help formulate policies aiming at alleviating sectoral imbalances and promoting balanced growth, and also benefit investors with devising optimal portfolio diversification strategies.
Factors related to work engagement among nursing staffs working in a university hospital

Stress management in hospital nurses, aimed to benefit both the individual and the organization, is an important issue because occupational stress in nurses increases with the advancement in medicine and increasing needs of patients. For the purpose of empowering nurses in work engagement, this study examined how nurse’ s demographic characteristics; work environment; turnover intentions; job support; and the presence of nurses with high work motivation and great empowerment, including job satisfaction, autonomy, and work effectiveness, were related to their work engagement. The study participants were 618 nurses in a university hospital. The Japanese short version of Utrecht Work Engagement Scale （UWES-J） was used to evaluate the work engagement. According to the results, significant differences in work engagement were recognized relating to age, marital status, presence of children, job type and status, turnover intentions, workplace atmosphere and human relations, social support, and presence of nurses with high work motivation and great empowerment. Results showed that a friendly atmosphere and good human relations in the workplace, appropriate leadership support for young nurses, and the creation of a work environment that young nurses can retain is beneficial in promoting work engagement. Additionally, it is important for the nurse manager, who is a key person in the social support network, to create a work environment for working lively, to enhance his or her own work engagement. （Accepted on February 5, 2016）
Abstract 5011: Tumor associated macrophages promote malignant phenotypes of disseminated human gastric cancer cells in intraperitoneal cancer immune microenvironment

Gastric cancer is the third leading cause of cancer-related death, and peritoneal dissemination is one of the most frequent site of recurrence. Although the role of tumor microenvironment is recognized, it is still unclear how intraperitoneal cancer-immune microenvironment contributes to peritoneal metastasis. Thus, we investigated the interaction between intraperitoneal cancer and immune cells, especially focusing on tumor-associated macrophages (TAM) in the peritoneal cavity. The peritoneal wash from gastric cancer patients was subjected to conventional cytology, flow cytometry, and immuno-fluorescent assay using antibodies against CD45 (leukocytes), CD14 (monocytes), CD80/163 (M1/M2 macrophages, respectively), in combination with genetically engineered cancer-imaging viral agent ‘TelomeScan’ which specifically expresses GFP in telomerase-positive cells. In cytology-positive samples, CD163-positive macrophages could be detected in approximately 70% of intraperitoneal macrophages with TelomeScan-positive cancer cells, while cytology negative samples contained few CD163-positive macrophages. In addition, peripheral blood mononuclear cells (PBMCs) from healthy volunteers were induced to differentiate into CD163-positive M2 macrophages (TAM-like macrophages), and co-cultured with gastric cancer cells to examine the effect on their malignant phenotype such as migration and invasion. We found that PBMCs-derived CD163-positive M2 macrophages significantly potentiated the ability of migration and invasion in gastric cancer cells. In case of existence of free cancer cells in peritoneal cavity, intraperitoneal macrophages appeared to differentiate into TAM and they potentially accelerate malignant phenotypes of gastric cancer cells. These results suggested that intraperitoneal cancer-immune microenvironment may play an important role to promote peritoneal disseminations in gastric cancer. Citation Format: Shuichi Sakamoto, Shunsuke Kagawa, Kazuya Kuwada, Atene Ito, Tetsuya Kagawa, Satoru Kikuchi, Shinji Kuroda, Ryuichi Yoshida, Hiroshi Tazawa, Toshiyoshi Fujiwara. Tumor associated macrophages promote malignant phenotypes of disseminated human gastric cancer cells in intraperitoneal cancer immune microenvironment [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 5011. doi:10.1158/1538-7445.AM2017-5011
The Behaviour of Mixtures of Sodium Iso-Butyl Xanthate and Sodium Di-Ethyl Dithiophosphate during the Flotation of a Cu-Ni-Pt Ore in Degrading Water Quality

The use of mixtures of thiol collectors is reportedly beneficial in sulfide flotation. This is becoming standard practice for many concentrators, but process water recirculation and re-use in flotation circuits may compromise the behaviour of such mixtures owing to changes in physicochemical interactions occurring in the pulp phase as a result of water quality variations. It is expected that changes in the pulp chemistry would in turn affect both the pulp and froth phase phenomena, thereby affecting flotation performance. Thus, this study considers mixtures of thiol collectors, sodium iso-butyl xanthate (SIBX), and sodium di-ethyl dithiophosphate (SEDTP) in degrading water quality. Bench-scale flotation tests were conducted on various molar ratios of the selected thiol collectors under different ionic strengths (0.0242 mol·dm−3 and 0.1212 mol·dm−3) of synthetic plant water. Increasing the ionic strength of synthetic plant water and SEDTP molar ratio resulted in an increase in water, solids, Cu, and Ni recoveries. Cu-Ni grades decreased in increasing SEDTP molar ratios. The highest Cu-Ni grades were obtained in degrading water quality. The increase in water and solids recoveries in increasing SEDTP and ionic strength of plant water is attributed to an increase in froth stability. It can be concluded that the increase in the ionic strength of plant water increased water recoveries and therefore froth stability in parallel with SEDTP’s froth stabilizing effect, thus suggesting an additive interaction on the froth stabilisation effect seen.
Repurposing a Smartwatch to Support Individuals With Autism Spectrum Disorder: Sensory and Operational Considerations

Smartwatches may provide a natural, portable, and unobtrusive strategy by which to support directive-following for individuals with autism spectrum disorders (ASD). A mentor can send visual supports (e.g., photographs, videos, text) “just-in-time” (JIT) to a learner’s smartwatch. This may reduce the need for extraneous face-to-face intervention within social and educational settings and thereby preserve the naturalness of interactions for individuals with ASD. In this article, the following questions are explored: (1) Will some children with ASD with limited functional speech tolerate wearing a smartwatch after receiving only spoken instructions? (2) Can children with ASD who did not initially tolerate wearing a smartwatch increase their tolerance for wearing a smartwatch after they view video models within a visual schedule? and (3) Will children with ASD who tolerate wearing a smartwatch attend to, and follow, scene cue text messages received on the watch? Results provide preliminary evidence for the feasibility of using a smartwatch with children with ASD. Limitations of this study are addressed and implications for future research are posited.
Subcycle nonlinear terahertz optics: a carrier dynamics approach.

The dynamics of free electrons in semiconductors play the central role in strong light-matter interaction with intense terahertz radiations. Terahertz pulse can serve as a transient voltage bias to drive high-field phenomena in solids. Various nonlinear effects can be excited by applying different terahertz field strengths and the observed experimental results are found to be extremely sensitive to the incident terahertz spectrum and its temporal profile. These properties suggest a rich variety of possible optoelectronic applications by controlling the carrier dynamics in semiconductors. In this thesis, we investigate the nonlinear terahertz responses of free charge carriers in semiconductors, such as the n-doped semiconductor In0.53Ga0. 47As and graphene, with terahertz time-domain spectroscopy as well as optical pump-terahertz probe spectroscopy. We start by discussing the terahertz responses of monolayer graphene. Then we discuss the significant impact of temporal dynamics in subcycle nonlinear optics. There are several limitations of the conventional Drude model and more importantly, the experimental observations may differ significantly within the well-known THz window. Strong subcycle nonlinear optics can only be achieved by carefully taking into account the time-scale of the variation in the temporal conductivity. Different experimental results are observed using different coherent terahertz sources in the frequency range between 0.1 and 3 THz. To retrieve nonlinear optics in the subcycle regime, we performed nonlinear THz-TDS on a common doped semiconductor material In0.53Ga0. 47As, which possesses a much higher carrier density and a high conductivity contrast before and after strong carrier heating induced by intervalley scattering. Our findings suggest an incoherent approach to subcycle control of terahertz high-frequency (or high-harmonic) generation based on intraband carrier scattering effects. These investigations will be important for future terahertz electronics and optoelectronics.
Cervical artery dissection after sports – An analytical evaluation of 190 published cases

Introduction Cervical artery dissections may be preceded by mechanical trigger events, often related to sports. Methods Using the MEDLINE database, we identified case reports and case series of sports-related cervical artery dissections. Information of the type of sport, age and gender of the patient, affected vessels, associated infarction, time delay, and neurological sequelae were extracted. Demographic and clinical characteristics were compared between sport groups using analysis of variance and Chi square tests. Differences were further assessed with adjusted post hoc tests and homogenous subsets. Results A total of 115 reports describing 190 patients with cervical artery dissections related to 45 different sports were identified. The mean age of all patients was 35 years; 26% of all patients were women. Anterior and posterior circulation, as well as left and right side were affected with similar frequency. Patients belonging to different sport categories differed significantly with regard to age (p < 0.001), gender (p < 0.001), and affected circulation (anterior vs. posterior, p = 0.02). The posterior circulation was most often affected in golf players (88%) and least often in individuals engaging in exercise (23%) and scuba divers (29%). Laterality (left vs. right) and mortality were similar between sport groups. Discussion We performed a comprehensive review and analytical evaluation of case reports describing patients with cervical artery dissections after sport. Confirmation of our findings in prospective studies is needed. Conclusion Cervical artery dissection has been described in relation to a wide variety of sports. The risk of injury to particular neurovascular structures may depend on the type sport involved. Discipline-specific incidence rates are not known.
Predicting environmentally friendly eating out behavior by value-attitude-behavior theory: does being vegetarian reduce food waste?

Abstract Growing concerns over the environment and climate has led to increased interest in environmentally friendly eating out, especially with respect to the need to reduce waste in the restaurant and catering sector as well as the adoption of new food norms, such as vegetarianism and veganism. The purpose of this study is to build and test an extended value (perceived value on sustainability)-attitude (attitude, personal norm, and social norm on waste reduction)-behavior (VAB) model to predict sustainable eating out behavior at restaurants. In addition, the moderating effect of being vegetarian or not is tested in relation to the VAB theory. The results reveal that the perceived value on sustainability has a highly significant effect on attitude, personal norms, and social norms on waste reduction. In addition, adoption of environmentally friendly eating is positively influenced, in descending order, by personal norms, social norms, and attitudes towards waste reduction. Furthermore, the eating styles of non-vegetarians and vegetarians moderate the six hypotheses on the VAB model.
MEDICO-LEGAL STUDY OF NON-FATAL ROAD TRAFFIC INJURIES

Background Road traffic accidents are global problems, which represent one of the major causes of disability and death worldwide leading to unpleasant results on individuals, their families and their society. Objective To study the incidence of road traffic accidents in relation to socio-demographic factors, and to find out the patterns and distribution of the resulting injuries. Method This study included (375) victims of road traffic accidents whom were brought to the casualty room in AL-Gamhoria Teaching Hospital in Aden-Yemen for medical and legal evaluation during the period from 1 st January up to 31 December 2010. Information collected consisted of personal identification data, and accident characteristics that were obtained from patients, close relatives, and other available persons who were present at the time of incidence. Results Only 140 (37.4%) of victims were hospitalized. 32% of road traffic accidents (RTAs) was observed among those aged 21-30 years with predominance of male (82.9%). The illiterates were the victims in 38.7%, students (48%), and single (60%). Most of cases from middle and lower socio-economic classes (53.3% and 40%, respectively). Pedestrians (38.5%) and passengers (35.7%) were the victims in most of cases. Light motor vehicle was involved in 61.5%. Sideway and hit and run were the most common types of collisions seen in (33.3% and 30.2%, of all cases respectively). Most of the accidents occurred between 12.01pm to 06.00pm. Most of the accidents occurred during summer season, mainly in the weekend. Multiple superficial injuries like abrasions, contusions, and lacerations wee the commonest pattern of injuries. Limb injuries were the most (46.5%) followed by the head (26.4%). Conclusion The middle aged group males were more common involved in road accidents. The pedestrians were mostly affected. The Injuries were mostly caused by light motor vehicles than other vehicles. Accidents were more common in the summer season and during weekend, in afternoon hours. Multiple superficial injuries were the commonest injury, and the head and limbs were the most common site of injuries among victims of non-fatal road traffic accidents.
Lurbinectedin (PM01183) with doxorubicin (DOX), an active treatment as second-line therapy in small cell lung cancer (SCLC).

7509 Background: PM01183 inhibits transactivated transcription and acts on the tumor microenvironment. It lacks cross-resistance with platinum. PM01183 and DOX are synergistic in vitro. Recommended dose (RD): 4 mg (or 2 mg/m2) + 50 mg/m2, respectively, both on day (D) 1 every 3 weeks. Compelling activity was observed earlier in 2nd line SCLC patients (pts), leading to a cohort expansion. The historical response rate (RR) of DOX-based combinations is around 20%. Methods: SCLC pts ≤ 75 years with ECOG PS 0-1, adequate organ function and 1 prior chemotherapy-containing line were included. Stable asymptomatic brain metastases were allowed. DOX was discontinued before reaching 450 mg/m2, non-progressing pts could continue on PM01183 alone. CSF prophylaxis was not mandatory. Results: 21 pts were treated and evaluable for efficacy [response rate (RR) by RECIST v1.1]. Male: 76%; median age: 62 y (r, 48-73); ECOG PS = 0/1 in 43%/57%; 29% had brain metastases, 62% had bulky disease and 81% responded to 1st line, 5%.
The IPN Regulates Anxiety Independently of Drug Addiction

V LIST OF FIGURES . VIII LIST OF ABBREVIATIONS . XI CHAPTER 1: GENERAL INTRODUCTION . 1 Anxiety & Addiction . 1 The Dorsal Diencephalic Conduction System . 2 The Medial Habenula . 4 The Interpeduncular Nucleus . 5 Role of the DDC in Addiction to Specific Drugs . 8 Alcohol . 8 Opioids . 9 Nicotine and Psychomotor Stimulants . 11 Role of the DDC in Emotional States . 14 Anxiety, fear, and stress. 14 Serotonin Signaling & Anxiety . 16 Serotonin & Anxiety in Humans . 17 Ethological Approaches to Anxiety . 22 Involvement of Serotonin in Anxiety . 25 Regulation of Anxiety by Serotoninoceptive Anatomical Structures . 26 Central Hypotheses . 36 References . 38 CHAPTER 2: THE INTERPEDUNCULAR NUCLEUS REGULATES BASELINE ANXIETY LEVELS . 50 Abstract . 51. 5
Partnership and innovation in the pharmaceutical industry: the case of clinical research

ABSTRACT This study attempts to test the hypothesis that collaborative research projects boost R&D performance. More specifically, through an empirical investigation, it ascertains which organizational solution best enhances scientific impact, focusing on a sample of phase II and III clinical trials and using citations in scientific journals as a measure. The main findings confirm that there are substantial differences in the ability of distinct research organizations to foster innovation, with the collaborative solution more likely to be productive. All in all, this result supports the literature asserting that collaborative networks play a productive role in knowledge domains. It may also offer an explanation for the puzzle characterizing the pharmaceutical industry, where extensive consolidation has coincided with a fall in R&D productivity.
A Simple Baseline for Multiple Instance and Weakly Supervised Learning

In this work we present a simple baseline for multiple instance learning (MIL). We learn a set representation, iteratively, by looking at the constituent elements of the set one at a time, using a recurrent neural network. The iterative analysis of set elements allows our approach to adapt the set representation so that it reflects whether relevant elements have been observed and whether the underlying structure has been matched. In addition, we show that our method is capable of modelling distributions at the instance-level, using only set-level annotations. Thus, it is able to operate in a weakly supervised fashion learning to predict instance-level labels without instance-level annotations. An extensive empirical evaluation on both simplified (MNIST) and realistic (Lookbook and Colon Cancer) datasets show that the proposed method is able to reach and surpass state-of-the-art MIL methods. Moreover, its performance on instance-level prediction is close to that of fully-supervised methods.
Path analysis on the Determinants of Pap Smear Utilization for Cervical Cancer Early Detection in Women of Reproductive Age

Background: Cervical cancer is the fourth most common Malignant cancer among women after breast, colorectal, and lung cancers. Pap smear has been recognized as an effective strategy for reducing the incidence and mortality rate of cervical cancer. This study aimed to investigate the determinants of Pap smear utilization for cervical cancer early detection in women of reproductive age using path analysis model.Subjects and Method: This was an analytic observational study with a case-control design. The study was conducted in Cilongok and Ajibarang Sub-districts, Banyumas, Central Java, from January 3 to February 3, 2018. A total sample of 200 women reproductive age was selected for this study by fixed disease sampling. The dependent variable was Pap smear utilization. The independent variables were education level, attitude, perception on the quality health care, access to the health center, family support, peer support, and health personnel support. The data were collected by questionnaire and analyzed by path analysis.Results: Pap smear utilization was positively and directly associated with education (b = 2.63; 95% CI= 1.77 to 3.48 p<0.001), perception on quality of health care (b= 1.04; 95% CI= 0.22 to 1.86; p= 0.012), attitude (b= 1.48; 95% CI= 0.51 to 2.44 p= 0.003), access to health center (b=1.02; 95% CI= 0.20 to 1.84 p= 0.015), family support (b= 1.29; 95% CI= -0.22 to 2.61; p= 0.029), and health personnel support (b= 2.02; 95% CI= 0.60 to 3.45 p= 0.005). Pap smear utilization was indirectly associated with peer support through perception on quality health care (b = 0.66; 95%= -0.01 to 1.33 p = 0.031). Conclusion: Education, perception on the quality of health care, attitude, access to the health center, family support, and health personnel support are directly associated with Pap smear utilization.Keywords: Pap smear, cervical cancer, path analysis, education, attitude, perception, family support, peer support, health personnel supportCorrespondence: Gesit Kusuma Wardhani. Masters Program in Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami No. 36 A, 57126, Surakarta, Central Java. Email: gesitkusuma92@gmail.com. Journal of Health Promotion and Behavior (2017), 2(4): 359-370https://doi.org/10.26911/thejhpb.2017. 02.04. 08
Developing a Nicotiana benthamiana – Citrus tristeza virus model system to study superinfection exclusion

Citrus tristeza (CTV) is the causal agent of economically devasting diseases that affect global citrus production. CTV has demonstrated superinfection exclusion (SIE), a phenomenon where a preexisting viral infection excludes a secondary infection by the same or closely related virus. This phenomenon has been used to develop cross-protection measures against CTV but there have been erratic results with this approach. Understanding of SIE by CTV on the molecular level has been challenging, especially due to time-consuming trials of over a year when citrus plants are used in the experiments. The purpose of this study was to develop a model system to study SIE by CTV by using a more amenable species, Nicotiana benthamiana, rather than citrus plants. cDNA constructs of CTV containing extra genes of the green or red fluorescent proteins (GFP/RFP) were engineered and transformed into Agrobacterium tumefaciens to visualize virus movement and SIE within the N. benthamiana plants by using the agro-infiltration approach for the virus constructs delivery. The constructs carrying the full-length wild-type virus with the additional GFP- or RFP-encoding gene and the GFP-tagged hybrid constructs with deletion in the p33 gene were infiltrated with the agro-suspension and visualized under a microscope. The images captured were analyzed for peaks in grayscale values in the green or red channels along a line. The constructs used in the study behaved similarly in N. benthamiana and Citrus macrophylla but the trial time was significantly shortened with the N. benthamiana plants. Thus, N. benthamiana is a suitable alternative for studying SIE by CTV with the constructs in this study.