Miracle-dz/UniFAR-FTUs huggingface dataset:
Correlations of HPV vaccine uptake among eight-grade students in Israel: the importance of ethnicity and level of religious observance

ABSTRACT In Israel, human papilloma virus (HPV) vaccines are included in the national childhood immunization program for eight-grade students, but uptake remains relatively low. This article explores which demographic factors are correlated with HPV vaccination rates. HPV vaccination data for the school year 2017–2018 was assessed among members of Maccabi Healthcare Services, the second largest health service provider in Israel. By matching eighth grade students to their family members’ demographic data via an electronic medical records (EMR) system, we assessed vaccination rates by taking into account sex, socioeconomic status (SES), ethnic categorization, and maternal characteristics. In a total of 45,160 eligible students, 55.3 percent of girls and 48.5 percent of boys were vaccinated for HPV. In a multivariable model, students in Arab communities had a significantly (p < .001) higher odds ratio (2.02; 95 percent CI:1.55–2.64) of being vaccinated, while ultra-orthodox (UO) Jewish students were much less likely to be vaccinated compared to all other students (OR = 0.05; 95 percent CI:0.05–0.06). Ethnicity and level of religious practice are major determinants of HPV vaccine uptake in Israel. This should be taken into account when planning intervention programs in order to improve the uptake of the vaccine.
Urinary Symptoms and their Impact on Young Women’s Sexual Function and Quality of Life

Abstract Sexuality and urinary function have received scarce research attention in younger women. In this cross-sectional survey study, prevalence, type, severity, and impact of urinary incontinence (UI), and its relationship with sexuality was investigated in 261 nulliparous women aged 18-27 (M = 19.08 years). Modules of the International Consultation on Incontinence Questionnaire and the Female Sexual Function Index assessed UI, sexual function, and quality of life. Thirty percent of the sample experienced UI, and 26% reported sexual function problems. A significant small negative correlation was found between UI and sexual lubrication (p = .017). Forty-three percent of participants in the total sample reported that they were bothered by urinary symptoms, and 13% avoided sexual activity due to urinary symptoms. Of those classified as incontinent, 90% were bothered by their symptoms. Urinary symptoms are impactful on the quality of life and sexual lives of young women, but despite their high prevalence, they remain a largely understudied and undertreated issue in this age group. Further research is crucial for improving awareness and access to treatment for this underserved population.
Effects of environmental conditions and catch processing on survival probability of plaice discards in the North Sea pulse trawl fishery

Undersized European plaice dominate the discarded fraction of the catch of the beam trawl fisheries for sole in the Southern North Sea. Effects of environmental conditions at sea and of the use of a water-filled hopper on the survival of undersized European plaice discarded by pulse trawl fisheries were explored. During trips with commercial pulse-trawlers catches were discharged in either water-filled hoppers or conventional dry hoppers. For both hoppers, undersized plaice were sampled from the sorting belt. After assessment of vitality status, sampled fish were housed in dedicated survival monitoring tanks on board. Upon return in the harbour fish were transferred to the laboratory to monitor their survival for up to 18 days post-catch. Conditions at sea, such as wave height and water temperature, as prevailing during these trips were recorded or obtained from public data sources. The overall estimate for the survival probability for plaice discarded by pulse trawl fisheries is 12% (95% CI: 8% - 18%). Both water temperature and vitality status had strong effects on survival probabilities of discarded plaice. Increasing water temperature increased mortality. The vitality of the fish could be moderately increased by using a water-filled hopper to collect the fish on deck, but we found no significant direct effect of hopper type on plaice discard survival. It seems that to increase discards survival, fish need to be landed on deck in much better condition by a reduction of the impact of capture and hauling processes on fish condition.
The Rip1 intramembrane protease contributes to iron and zinc homeostasis in Mycobacterium tuberculosis

ABSTRACT Mycobacterium tuberculosis is exposed to a variety of stresses during a chronic infection, as the immune system simultaneously produces bactericidal compounds and starves the pathogen of essential nutrients. The intramembrane protease, Rip1, plays an important role in the adaptation to these stresses, at least partially by the cleavage of membrane-bound transcriptional regulators. Although Rip1 is known to be critical for surviving copper intoxication and nitric oxide exposure, these stresses do not fully account for the regulatory protein’s essentiality during infection. In this work, we demonstrate that Rip1 is also necessary for growth in low-iron and low-zinc conditions, similar to those imposed by the immune system. Using a newly generated library of sigma factor mutants, we show that the known regulatory target of Rip1, SigL, shares this defect. Transcriptional profiling under iron-limiting conditions supported the coordinated activity of Rip1 and SigL and demonstrated that the loss of these proteins produces an exaggerated iron starvation response. These observations demonstrate that Rip1 coordinates several aspects of metal homeostasis and suggest that a Rip1- and SigL-dependent pathway is necessary to thrive in the iron-deficient environments encountered during infection. IMPORTANCE Metal homeostasis represents a critical point of interaction between the mammalian immune system and potential pathogens. While the host attempts to intoxicate microbes with high concentrations of copper or starve the invader of iron and zinc, successful pathogens have acquired mechanisms to overcome these defenses. Our work identifies a regulatory pathway consisting of the Rip1 intramembrane protease and the sigma factor, SigL, that is essential for the important human pathogen, Mycobacterium tuberculosis, to grow in low-iron or low-zinc conditions such as those encountered during infection. In conjunction with Rip1’s known role in resisting copper toxicity, our work implicates this protein as a critical integration point that coordinates the multiple metal homeostatic systems required for this pathogen to survive in host tissue. Metal homeostasis represents a critical point of interaction between the mammalian immune system and potential pathogens. While the host attempts to intoxicate microbes with high concentrations of copper or starve the invader of iron and zinc, successful pathogens have acquired mechanisms to overcome these defenses. Our work identifies a regulatory pathway consisting of the Rip1 intramembrane protease and the sigma factor, SigL, that is essential for the important human pathogen, Mycobacterium tuberculosis, to grow in low-iron or low-zinc conditions such as those encountered during infection. In conjunction with Rip1’s known role in resisting copper toxicity, our work implicates this protein as a critical integration point that coordinates the multiple metal homeostatic systems required for this pathogen to survive in host tissue.
Non parametric multiple comparisons of non nested rival models

ABSTRACT The practice for testing homogeneity of several rival models is of interest. In this article, we consider a non parametric multiple test for non nested distributions in the context of the model selection. Based on the linear sign rank test, and the known union–intersection principle, we let the magnitude of the data to give a better performance to the test statistic. We consider the sample and the non nested rival models as blocks and treatments, respectively, and introduce the extended Friedman test version to compare with the results of the test based on the linear sign rank test. A real dataset based on the waiting time to earthquake is considered to illustrate the results.
Are support groups beneficial for fibromyalgia patients? The negative effects of social comparison for those who want it most

Peer support plays an important role in coping with many chronic health problems. Peer support may, however, contain a risk. Research has indicated that people with high social comparison orientation (SCO) are, on the one hand, more interested in contact with peers, but may, on the other hand, be negatively affected when they are confronted with peers who are worse-off. The present research studied the influence of SCO on the affective consequences of social comparison with worse-off peers during peer support among fibromyalgia patients. We predicted that fibromyalgia patients, as they have a higher SCO seek more contact with other fibromyalgia patients, identify themselves more strongly with worse-off fibromyalgia patients, and experience more negative affect when meeting worse-off fibromyalgia patients because of this increased identification. The study was carried out among 88 fibromyalgia patients recruited at support group meetings and through the website of a Dutch organization for fibromyalgia patients. The results supported our hypothesis. Despite the many beneficial effects of peer support, the present study showed that as fibromyalgia patients have a higher need to compare themselves with others, they are more negatively affected by social comparison with peers who are worse-off, because they tend to identify themselves with worse-off others.
Artificial Intelligence machine learning and conventional physical therapy for upper limb outcome in patients with stroke: a systematic review and meta-analysis.

OBJECTIVE The goal of this study was to compare the effect of different artificial intelligence (AI) machine learning and conventional therapy (CT) on upper limb impairments in patients with stroke. MATERIALS AND METHODS PubMed, PubMed Central, Google Scholar, MEDLINE, Cochrane Library, Web of Science, Research Gate, and Wiley Online Library were searched. Descriptive statistics about variables were reported to calculate standardized mean differences in outcomes of motor control (the primary outcome), functional independence, upper extremity performance, and muscle tone. The Physiotherapy Evidence Database (PEDro) Scale was used to assess qualitative papers. The primary outcomes of AI and CT have been included in the meta-analyses. RESULTS Ten papers with a total of 481 stroke patients were included and upper limb rehabilitation, upper limb functioning, and basic manual dexterity were examined. The heterogeneity test of the whole included measures (I2=45%) was medium. There were significant differences between the included measures (p-value=0.03) with a total SMD of 0.10 [0.01, 0.19]. According to the test for subgroup difference, it was found that there was a highly significant difference between the subgroups of the included measures (p-value=0.01) and the heterogeneity test (I2=59.8%). CONCLUSIONS AI is a feasible and safe method in post-stroke rehabilitation and improves upper-extremity function compared to CT. Significant AI post-treatment effects on upper-limb impairments have been observed. The findings showed that higher-quality evidence was detected in six assessment scales. However, a lower quality of evidence was detected in other scales. This indicated large or very large and consistent estimates of the treatment effects, and researchers were confident about the results. Therefore, the included observational studies are likely to provide an overestimate of the true effect.
Exenatide as an adjunct to nicotine patch for smoking cessation and prevention of postcessation weight gain among treatment-seeking smokers with pre-diabetes and/or overweight: study protocol for a randomised, placebo-controlled clinical trial

Introduction Obesity and smoking are the two leading causes of preventable death in the USA. Unfortunately, most smokers gain weight after quitting. Postcessation weight gain (PCWG) is frequently cited as one of the primary barriers to a quit attempt and a common cause of relapse. Further, excessive PCWG may contribute to the onset or progression of metabolic conditions, such as hyperglycaemia and obesity. The efficacy of the current treatments for smoking cessation is modest, and these treatments have no clinically meaningful impact on mitigating PCWG. Here, we outline a novel approach using glucagon-like peptide 1 receptor agonists (GLP-1RA), which have demonstrated efficacy in reducing both food and nicotine intake. This report describes the design of a double-blind, placebo-controlled, randomised clinical trial that evaluates the effects of the GLP-1RA exenatide as an adjunct to nicotine patches on smoking abstinence and PCWG. Methods and analysis The study will be conducted at two university-affiliated research sites in Houston, Texas, the UTHealth Center for Neurobehavioral Research on Addiction and Baylor College of Medicine Michael E. DeBakey VA Medical Centre. The sample will consist of 216 treatment-seeking smokers with pre-diabetes (haemoglobin A1c of 5.7%–6.4%) and/or overweight (body mass index of 25 kg/m2 or above). Participants will be randomised (1:1) to receive subcutaneous injections of placebo or 2 mg exenatide, once weekly for 14 weeks. All participants will receive transdermal nicotine replacement therapy and brief smoking cessation counselling for 14 weeks. The primary outcomes are 4-week continuous abstinence and changes in body weight at the end of treatment. The secondary outcomes are (1) abstinence and changes in body weight at 12 weeks post end of treatment and (2) changes in neuroaffective responses to cigarette-related and food-related cues as measured by electroencephalogram. Ethics and dissemination The study has been approved by the UTHealth Committee for the Protection of Human Subjects (HSC-MS-21-0639) and Baylor College of Medicine Institutional Review Board (H-50543). All participants will sign informed consent. The study results will be disseminated via peer-reviewed publications and conference presentations. Trial registration number NCT05610800.
HOURS AND COSTS OF FORMAL AND INFORMAL CARE FOLLOWING TRAUMATIC BRAIN INJURY AND SPINAL CORD INJURY SUSTAINED THROUGH MOTOR VEHICLE ACCIDENTS: A CROSS-SECTIONAL STUDY

Objectives To explore the weekly utilization of formal and informal care, and to calculate and compare the costs associated with these types of care after traumatic brain injury or spinal cord injury sustained through a motor vehicle accident in Australia. Design Cross-sectional, quantitative design. Subjects A total of 81 people with traumatic brain injury and 30 people with spinal cord injury from 3 rehabilitation units in New South Wales, Australia. Methods Data were collected using questionnaires administered through semi-structured interviews, and analysed using a series of Kruskal–Wallis tests. Results Spinal cord injury (tetraplegia/ paraplegia) was significantly more expensive for both formal and informal care compared with traumatic brain injury. The costs of formal care were significantly greater for those in the traumatic brain injury group who had a more severe injury (post-traumatic amnesia > 90 days) compared with the other traumatic brain injury groups (post-traumatic amnesia 7–28 days, 29–90 days). The costs of informal care were significantly higher for both traumatic brain injury and spinal cord injury compared with the costs of formal care. Conclusion This study highlights the complementary role of formal and informal care in supporting people with traumatic brain injury or spinal cord injury, particularly highlighting the significant role of informal care, which needs to be more explicitly acknowledged in policy and planning processes. LAY ABSTRACT This study explored the weekly utilization and annual costs of formal (paid support) and informal care (unpaid support) for 81 individuals with traumatic brain injury and 30 with spinal cord injury, sustained in motor vehicle accidents in Australia. Researchers conducted interviews with study participants, who were active clients of 3 separate rehabilitation units in New South Wales (NSW), Australia. Utilization of care differed across and within groups; however, the results showed significantly higher costs for spinal cord injury than for traumatic brain injury. Those with more severe traumatic brain injuries also had significantly higher costs. Finally, informal care was utilized significantly more than formal care services and contributed towards a greater annual “cost”. Overall, these results demonstrate the significant role that informal care has following traumatic brain injury or spinal cord injury. This study highlights the overall importance and value of informal care being recognized more in policy and planning processes.
Chronic exposure to ampicillin alters lung microbial composition in laboratory rat

Abstracts Purpose High-throughput sequencing technologies have revealed that the lungs contain a variety of low biomass microbiota associated with various lung diseases. Rat model is an important tool to understand the possible causal relationship between pulmonary microbiota and diseases. Antibiotic exposure can alter the microbiota, however, a direct influence of long-term ampicillin exposure on commensal bacteria of healthy lungs has not been investigated, which could be useful in the study of the relation between microbiome and long-term lung diseases, especially in animal model-making of lung diseases. Methods The rats were aerosolized ampicillin of different concentrations for five months, and then the effect on the lung microbiota was investigated using 16S rRNA gene sequencing. Results The ampicillin treatment by a certain concentration (LA5, 0.2 ml of 5 mg/ml ampicillin) administration leads to profound changes in the rat lung microbiota but not in the low critical ampicillin concentration (LA01 and LA1, 0.1 and 1 mg/ml ampicillin), when compared to the untreated group (LC). The genus Acidobacteria_Gp16 dominated the ampicillin treated lung microbiota while the genera Brucella, Acinetobacter, Acidobacteria_Gp14, Sphingomonas, and Tumebacillus dominated the untreated lung microbiota. The predicted KEGG pathway analysis profile revealed some difference in the ampicillin treated group. Conclusions The study demonstrated the effects of different concentrations of ampicillin treatment on lung microbiota of rats in a relatively long term. It could serve as a basis for the clinical use of antibiotic and the use of ampicillin to control certain bacteria in the animal model-making of respiratory diseases such as chronic obstructive pulmonary disease.
Adults with a history of childhood maltreatment with and without mental disorders show alterations in the recognition of facial expressions

ABSTRACT Background: Individuals with child maltreatment (CM) experiences show alterations in emotion recognition (ER). However, previous research has mainly focused on populations with specific mental disorders, which makes it unclear whether alterations in the recognition of facial expressions are related to CM, to the presence of mental disorders or to the combination of CM and mental disorders, and on ER of emotional, rather than neutral facial expressions. Moreover, commonly, recognition of static stimulus material was researched. Objective: We assessed recognition of dynamic (closer to real life) negative, positive and neutral facial expressions in individuals characterised by CM, rather than a specific mental disorder. Moreover, we assessed whether they show a negativity bias for neutral facial expressions and whether the presence of one or more mental disorders affects recognition. Methods: Ninety-eight adults with CM experiences (CM+) and 60 non-maltreated (CM−) adult controls watched 200 non-manipulated coloured video sequences, showing 20 neutral and 180 emotional facial expressions, and indicated whether they interpreted each expression as neutral or as one of eight emotions. Results: The CM+ showed significantly lower scores in the recognition of positive, negative and neutral facial expressions than the CM− group (p < .050). Furthermore, the CM+ group showed a negativity bias for neutral facial expressions (p < .001). When accounting for mental disorders, significant effects stayed consistent, except for the recognition of positive facial expressions: individuals from the CM+ group with but not without mental disorder scored lower than controls without mental disorder. Conclusions: CM might have long-lasting influences on the ER abilities of those affected. Future research should explore possible effects of ER alterations on everyday life, including implications of the negativity bias for neutral facial expressions on emotional wellbeing and relationship satisfaction, providing a basis for interventions that improve social functioning. HIGHLIGHTS Child maltreatment (CM) in adults is linked to emotion recognition alterations if no current mental disorders are present. Interpretation of positive, negative and neutral facial expressions is impaired. Adults with a history of CM tend to interpret neutral expressions as negative.
Coccolithophores and diatoms resilient to ocean alkalinity enhancement: A glimpse of hope?

It is increasingly apparent that adequately mitigating anthropogenic climate interference will require ocean carbon dioxide removal (CDR) strategies. Ocean alkalinity enhancement (OAE) is an abiotic ocean CDR approach that aims to increase the ocean’s CO2 uptake capacity through the dispersal of pulverized mineral or dissolved alkali into the surface ocean. However, OAE’s effect on marine biota is largely unexplored. Here, we investigate the impacts of moderate (~700 μmol kg−1) and high (~2700 μmol kg−1) limestone-inspired alkalinity additions on two biogeochemically and ecologically important phytoplankton functional group representatives: Emiliania huxleyi (calcium carbonate producer) and Chaetoceros sp. (silica producer). The growth rate and elemental ratios of both taxa showed a neutral response to limestone-inspired alkalinization. While our results are encouraging, we also observed abiotic mineral precipitation, which removed nutrients and alkalinity from solution. Our findings offer an evaluation of biogeochemical and physiological responses to OAE and provide evidence supporting the need for continued research into how OAE strategies affect marine ecosystems.
miR‐200a‐3p regulates epithelial–mesenchymal transition and inflammation in chronic rhinosinusitis with nasal polyps by targeting ZEB1 via ERK/p38 pathway

Several biological processes are regulated by miR‐200a‐3p, including cell proliferation, migration, and epithelial–mesenchymal transition (EMT). In this study we aimed to uncover the diagnostic value and molecular mechanisms of miR‐200a‐3p in chronic rhinosinusitis with nasal polyps (CRSwNP).