Miracle-dz/UniFAR-FTUs huggingface dataset:
A graded spherical tissue under thermal therapy : the treatment of cancer cells

In the present analysis, the bio-heat equation has been studied in the context of memory responses which is defined in the form of convolution having kernels as power functions. The heat transport equation for this problem involving the memory-dependent derivative on a slipping interval in the context of Dual-phase (DP) lag model, which is used to study the thermal damage within the graded spherical skin tissue during the thermal therapy, whose outer surface is thermally insulated. Laplace transform technique is implemented to solve the governing equations. The influences of the memory-dependent derivative and time-dependent moving heat source velocity on the temperature of skin tissues and the thermal injuries are precisely investigated. The thermal injuries to the tissue are assessed by the denatured protein range using the current formulation in which the numerical inversion of the Laplace transform is carried out using Zakian method. The numerical outcomes of thermal injuries and temperatures have been represented graphically. Excellent predictive capability is demonstrated for identification of appropriate procedure to select different kernel functions to reach effective heating in hyperthermia treatment. The significant effect of the thermal therapy is reported due to the effect of nonhomogeneity and delay time also.
Gaya Kepemimpinan Camat dalam Upaya Mencapai Tujuan Organisasi Kantor Kecamatan Lore barat Kabupaten Poso

Penelitian ini bertujuan Untuk mengetahui bagaimana Gaya Kepemimpinan Camat Dalam Upaya Mencapai Tujuan Organisasi Kantor Kecamatan Lore Barat Kabupaten Poso, serta faktor-faktor yang mempengaruhinya. Adapun metode penelitian yang digunakan adalah penelitian survei sebagai dasar dengan tipe penelitian deskriptif. Teknik pengumpulan data dilakukan menggunakan teknik observasi, wawancara mendalam serta dokumentasi dengan melibatkan informan yang berkompeten dan bisa dianggap dapat memberikan informasi yang dibutuhkan serta penelusuran data atau dokumen – dokumen. Data yang diperoleh selanjutnya dianalisis secara kualitatif dengan menjelaskan atau menggambarkan data yang diteliti atau di dapatkan dari lapangan, baik data primer yang diperoleh dari hasil wawancara, maupun dari data sekunder yang diperoleh melalui penelusuran pustaka dan dokumen dari berbagai sumber resmi. Dari hasil penelitian yang dilakukan menunjukkan bahwa Gaya Kepemimpinan Camat Dalam Upaya Mencapai Tujuan Organisasi Kantor Kecamatan Lore Barat Kabupaten Poso adalah gaya konsultatif, partisipasi, demokratis dan motivator. Tetapi, belum dapat dijalankan secara maksimal oleh Camat sehingga tujuan organisasi tidak dapat tercapai secara maksimal. Adapun faktor yang mempengaruhi Faktor yang mempengaruhi adalah faktor keluarga, SDM dan fasiltas penunjang yang belum memadai.
G-Protein biased opioid agonists: 3-hydroxy-N-phenethyl-5-phenylmorphans with three-carbon chain substituents at C9.

A series of compounds have been synthesized with a variety of substituents based on a three-carbon chain at the C9-position of 3-hydroxy-N-phenethyl-5-phenylmorphan (3-(2-phenethyl-2-azabicyclo[3.3.1]nonan-5-yl)phenol). Three of these were found to be μ-opioid receptor agonists in the inhibition of forskolin-induced cAMP accumulation assay and they did not recruit β-arrestin at all in the PathHunter assay and in the Tango assay. Compound 12 (3-((1S,5R,9R)-2-phenethyl-9-propyl-2-azabicyclo[3.3. 1]nonan-5-yl)phenol), 13 (3-((1S,5R,9R)-9-((E)-3-hydroxyprop-1-en-1-yl)-2-phenethyl-2-azabicyclo[3.3. 1]nonan-5-yl)phenol), and 15a (3-((1S,5R,9R)-9-(2-hydroxypropyl)-2-phenethyl-2-azabicyclo[3.3. 1]nonan-5-yl)phenol) were partial μ-agonists. Two of them had moderate efficacies (E MAX ca. 65%) and one had lower efficacy, and they were ca. 5, 3, and 4 times more potent, respectively, than morphine in vitro. Computer simulations were carried out to provide a molecular basis for the high bias ratios of the C9-substituted 5-phenylmorphans toward G-protein activation.
Childhood Significant Experiences that Contribute to Christian Commitment in Young Adulthood

Childhood experiences are significant to adult spirituality. Understanding these influential experiences can assist professors of Christian education as they seek to empower future children’s ministry workers. This article seeks to understand how childhood experiences influence adult spirituality. In-depth interviews and grounded theory were utilized on 21 participants between 22 and 30 years old. Results from this study created seven themes revealing the childhood experiences that contribute to Christian commitment in young adulthood.
Hemoglobin adducts of the organophosphate insecticide azinphos-methyl

approved: Reported here is an investigation to determine if azinphos-methyl (AZM), an organophosphate insecticide, adducts to hemoglobin, and if so, whether the hemoglobin adduct could be used as a quantitative marker of occupational AZM exposure. We hypothesized that AZM, or a metabolite of AZM, binds to hemoglobin in erythrocytes forming an adducted protein. We administered radiolabled AZM to rats and found a stable, dose-dependent association of radioactivity with hemoglobin. The decline in hemoglobin-associated radioactivity followed the expected kinetics of erythrocyte turnover in rats. We examined hemoglobin isolated from these rats by high-pressure liquid chromatography, liquid scintillation counting, and electrospray ionization mass spectrometry. These analyses provided evidence of AZM or an AZM metabolite binding to one of the beta proteins of hemoglobin. In vitro incubation of AZM with hemoglobin in a liver microsome system indicated an AZM adduct to heme. Further research is necessary to fully characterize the adduct and determine whether this biomarker will be useful for monitoring human exposure to AZM. Redacted for Privacy ' Copyrig ht by Bonnie J. Bailey May 5, 2000 All Rights Reserved Hemoglobin Adducts of the Organophosphate Insecticide Azinphos-methyl by Bonnie J. Bailey A DISSERTATION submitted to Oregon State University in partial fulfillment of the requirements for the degree of Doctor of Philosophy Presented May 5, 2000 Commencement June 2000 Doctor of Philosophy dissertation of Bonnie J. Bailey presented on May 5, 2000
Ancient DNA suggests modern wolves trace their origin to a Late Pleistocene expansion from Beringia

Grey wolves (Canis lupus) are one of the few large terrestrial carnivores that maintained a wide geographic distribution across the Northern Hemisphere throughout the Pleistocene and Holocene. Recent genetic studies have suggested that, despite this continuous presence, major demographic changes occurred in wolf populations between the late Pleistocene and early Holocene, and that extant wolves trace their ancestry to a single late Pleistocene population. Both the geographic origin of this ancestral population and how it became widespread remain a mystery. Here we analyzed a large dataset of novel modern and ancient mitochondrial wolf genomes, spanning the last 50,000 years, using a spatially and temporally explicit modeling framework to show that contemporary wolf populations across the globe trace their ancestry to an expansion from Beringia at the end of the Last Glacial Maximum - a process most likely driven by the significant ecological changes that occurred across the Northern Hemisphere during this period. This study provides direct ancient genetic evidence that long-range migration has played an important role in the population history of a large carnivore and provides an insight into how wolves survived the wave of megafaunal extinctions at the end of the last glaciation. Moreover, because late Pleistocene grey wolves were the likely source from which all modern dogs trace their origins, the demographic history described in this study has fundamental implications for understanding the geographical origin of the dog.
Distribution of the meadow lizard in Europe and its realized ecological niche model

ABSTRACT One of the most interesting but elusive members of the European herpetofauna is the meadow lizard (Darevskia praticola). It is a small, ground dwelling, predominantly forest living lacertid, for which many ecological and biological data are still missing. Moreover, at least for the western part of the species range (south-eastern Europe) its distribution and environmental associations are insufficiently known, likely due to difficulties in detection even with intensive field sampling. Here, we complemented the available literature records with our personal observations and explored the effects of environmental factors shaping the species ecological niche and distribution in Europe using the ecological niche modelling approach from Maxent software. The new records of the meadow lizard fill a gap in its known distribution. The most suitable habitats are in central and eastern Serbia, south-western Romania, and central, southern and south-western Bulgaria. Mean temperature of the coldest quarter, vegetation and slope had the strongest effect in defining the meadow lizard’s ecological niche. Niche suitability increased with the increase in forest cover and slope, while the temperature showed a bell-shaped response with a rather narrow tolerance range for temperature. Contrary to expectations, precipitation seemed to have no contribution to the species occurrence. Ecological niche model performance increased with a higher resolution of predictor variables despite the lower number of available occurrence records, although the slope variable had a greater predictive power when calculated at a lower resolution. Interestingly, high resolution vegetation variables (30 m) were able to show some level of habitat fragmentation, which likely resulted from deforestation. Overall, our results epitomize the effects of limited sampling on the biogeography inference of elusive species while having significant repercussions on conservation priorities and management of the species.
Development of Akkaraman Lambs in Cankiri Region from Birth to 120 Days

The aim of this study is to determine the development of the Akkaraman lambs grown in the Cankiri province until the age of four months by weighing them at different periods and prepare the growth curve. The animal material of this study was formed a total of 281 heads of Akkaraman breed lamb from 7 farms, born in 2018, grown in Cankiri province. In this study, average birth, 60, 90 and 120 days weight average were found 4.264 kg, 22.114 kg, 30.147 kg, and 34.950 kg, respectively. In the study, the gender effect on birth weight was not statistically significant (p>0.05), while the effect of type of birth was found statistically significant (p<0.001). The effect of birth type was statistically significant (p<0.05) on 2, 3 and 4 months of age, body weight; the farm conditions had significant effect on birth weight (p<0.001). The determination coefficient (R²) in the improvement of the lambs from birth to 4th month age was found 0.918.
Impacts of windbreak shelter on crop and livestock production

Abstract. Agroforestry (the integration of trees into agricultural landscapes) has been promoted, in Australia and elsewhere, as a way to increase farm productivity by providing a wide range of benefits. Despite this, adoption of agroforestry in Australian agricultural systems remains low. To implement agroforestry, farmers must be convinced the benefits of including trees outweigh the costs. This review evaluates the available quantitative data on shelter benefits with emphasis on Australian conditions, identifies key research gaps and determines if there is sufficient knowledge to make accurate predictions about impacts on farm productivity. Availability of quantitative data on windbreak shelter benefits was examined in five key areas; water use and evaporation, crop/pasture production, livestock mortality, livestock productivity and the capacity to model impacts of windbreaks on crop/livestock systems. Good quantitative data exists for many areas, particularly for changes in environmental conditions following tree establishment, however there were many gaps in key areas. Importantly, the ability to predict crop growth under spatially and temporally variable environmental conditions and the impact of windbreaks on livestock productivity is not yet able to be meaningfully quantified. Thus modelling the profitability of windbreaks is difficult and existing models require additional quantitative data to validate and improve them.
Comparison of Viral Clearance between Ivermectin with Doxycycline and Hydroxychloroquine with Azithromycin in COVID-19 Patients

Introduction: The whole world is on the brink of collapse due to the outbreak of COVID-19 with no solution to treat these cases with any specific drug. Extensive search for the Vaccine or effective treatment is going on while alarming infection and death toll is rising every day. Aim: The study will compare the effect of Ivermectin with Doxycycline and Hydoxychloroquine with Azythromicin on a selective group of COVID -19 positive patients. Method: This is a comparative study that included 400 patients of COVID 19 positive patient who were divided in to two groups. GroupA Received Ivermectin with Doxycycline and the other groupB received hydroxichloroquine(HCQ) with azithromycin. Result: Viral clearance is 132 ( 66%) on day 5 and 167( 83.5% ) on day 6. Among them 33(16.5%) remain PCR positive after 6th day of Ivermectin ingestion in Group A. Whereas there is154 ( 77.0%) viral clearance at 11th day and 163(81.5%) viral clearance at 12th day of Hydroxychloroquine ingestion in Group B. Among them 37 (18.5%) remain PCR positive after 12 day in group B. The P value is 0.000427 which is significant considering 5th day viral clearance of Ivermectin ingestion and 11th day of Hydroxychloroquine ingestion. But considering 6th day and 12th day the P-value is 0.59 which is not significant. Conclusion: It appears Ivermectin and Doxycycline is safeand effective combination drug therapy in COVID19infected patients but need further extensive study to find out the scope of application on other groups of patients.
Defects and Lattice Instability in Doped Lead-Based Perovskite Antiferroelectrics: Revisited

This paper is a summary of earlier results that have been completed with recent investigations on the nature and sequence of phase transitions evolving in the antiferroelectric PbZrO3 single crystals doped with niobium and Pb(Zr0.70Ti0.30)O3 ceramics doped with different concentration of Bi2O3. It was found that these crystals undergo new phase transitions never observed before. To investigate all phase transitions, different experimental methods were used to characterize the crystal properties. Temperature and time dependencies have been tentatively measured in a wide range, including a region above Tc, where precursor dynamics is observed in the form of non-centrosymmetric regions existing locally in crystal lattices. Also, coexistence of antiferroelectric phase and one of the intermediate phases could be observed in a wide temperature range. The phase transition mechanism in PbZrO3 is discussed, taking into account the local breaking of the crystal symmetry above Tc and the defects of crystal lattices, i.e., those generated during crystal growth, and intentionally introduced by preheating in a vacuum or doping with hetero-valent dopant.
Hypothyroidism and hyperprolactinemia in women with primary and secondary infertility

Background and objectives: Infertility is a global health problem including Bangladesh. Altered thyroid and prolactin levels have been implicated as a cause of infertility. The study was undertaken to find out the serum thyroid hormones and prolactin status in women with primary and secondary infertility. Methods: Women with primary and secondary infertility were enrolled. Fertile age-matched women were included as control. The anthropometric details (age, height and weight) were recorded. Overnight fasting blood sample was collected on 2nd day of menstrual cycle of the follicular phase. Serum thyroid stimulating hormone (TSH), free tri-iodothyronine (FT3) and free thyroxine (FT4) were measured by enzyme-linked immunosorbent assay (ELISA). Serum prolactin (PRL) was estimated by radioimmunoassay. Results: A total of 150 women were enrolled in the study. Out of 150 women, 50 had primary and 50 had secondary infertility while 50 women were age-matched fertile women as control. The mean TSH levels of both infertility groups were significantly higher than that of fertile women. Regarding thyroid function, 24% and 28% of women with primary and secondary infertility had hypothyroidism respectively. The serum prolactin level was high in 42.9% and 50% of hypothyroid cases in primary and secondary infertility groups respectively. Conclusion: The study has demonstrated high occurrence of hypothyroidism with raised serum prolactin levels among infertile females emphasizing the importance of estimating both serum TSH and prolactin in infertility. IMC J Med Sci 2020; 14(1): 009. EPub date: 11 May 2020
Taxation, Social Welfare, and Labor Market Frictions

Taking inefficiencies from taxation as given, a well-known public finance literature shows that the elasticity of taxable income (ETI) is a sufficient statistic for assessing the deadweight loss (DWL) from taxing labor income in a static neoclassical framework. Using a theoretical approach, we revisit this result from the vantage point of a general equilibrium macroeconomic model with labor search frictions. We show that, in this context, and against the backdrop of inefficient taxation, DWL can be up to 38 percent higher than the ETI under a range of reasonable parametric assumptions. Externalities arising from market participants not taking into account the impact of changes in their search- and vacancy-posting activities on other market participants can amplify this divergence substantially. However, with theoretical precision, we show how the wedge between the ETI and DWL can be controlled for, using readily observable variables.
Active tuberculosis among adult HIV-infected patients accessing antiretroviral therapy in a tertiary health facility in Lafia, northcentral Nigeria

Background: Tuberculosis and Human Immunodeficiency Virus (HIV) co-infection is a major problem in Nigeria and other countries that are ravaged by a high burden of both diseases. The World Health Organization (WHO) reports that the risk of developing active tuberculosis (TB) among people living with HIV is 16-27 times that of HIV negative persons. Although antiretroviral therapy (ART) reduces the risk of developing TB, there are factors which predispose those on ART to TB. This study sought to determine the prevalence of TB among adults on ART in our facility and identify the predisposing factors. Methodology: This was a retrospective study utilizing data from clinical records (folders and electronic) of adult HIV patients who are accessing ART in our facility and have been on ART for at least 6 months. A proforma was used to collect data including demographic, clinical, ART and laboratory information of the patients. The data were entered into SPSS version 23 and analyzed using descriptive statistics and bivariate analysis. Associations were tested using Chi square with 95% confidence level. Results: A total of 457 patients were studied, aged 18-69 years (mean age 38.3± 10 years), and 72.4% females. Majority were married (81%), unemployed (53.8%), had mean baseline CD4 cell count of 267.4 ± 185 cells/mm3 and a mean duration on ART of 100.9± 39 months. Seventeen point three percent of the patients had a previous history of TB before or within 6 months of commencement of ART. Thirteen (2.8%) of the patients had active TB while on ART. Majority of those who had active TB were females (76.9%), married (76.9%), unemployed (46%), had no previous history of TB (53.8%), baseline CD4 cell count of ≤ 350 cells/mm3 and were on first line ART medication. There was however no significant statistical association of active TB with any of these factors. Conclusion: Few patients had active TB while on ART in this study. The high frequency of TB in those who had low baseline CD4 cell count and baseline WHO stage shows the importance of early initiation of ART in people living with HIV (PLHIV). There is need for regular screening of PLHIV for TB and innovative approaches to get people with HIV to know their TB status as well as early commencement of ART. Keywords: Human immunodeficiency virus, Active Tuberculosis, Antiretroviral therapy.
Detection Cell-Free DNA (cfDNA) Using Nested-PCR as a Diagnosis Tool for Human Fascioliasis Infection

1. Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran 2. Department of Medical Biotechnology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran 3. Infectious Diseases Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran 4. Center for Research of Endemic Parasites of Iran (CREPI), Tehran University of Medical Sciences, Tehran, Iran 5. Department of Medical Parasitology, School of Medicine, Zabol University of Medical Sciences, Zabol, Iran
Retrospective study on sero-epidemiology of peste des petits ruminants before its official confirmation in northern Tanzania in 2008

A retrospective sero-epidemiological investigation of Peste des petits ruminants (PPR) was carried out in Ngorongoro district, situated in northern part of Tanzania and bordering Kenya. The study involved collection of field information from 101 respondents who own goats and sheep in four villages which had experienced a ‘rinderpest-like’ syndrome in domestic small ruminants between first suspected cases of PPR in 1995 and official confirmation of the disease in Tanzania in 2008. A total number of 198 serum samples from goats and sheep collected in 1998 and 2004 for different research projects or suspected disease investigation were retrieved from the Veterinary Investigation centre (VIC) Arusha and subjected to competitive ELISA test for detecting antibodies to PPR virus. Findings of this study suggest that PPR was in northern Tanzania at least four years before official confirmation and reporting based on clinico-pathological grounds, local field-based reports from livestock field officers and District Veterinary Officer. The seroprevalence of PPR from 198 serum samples analysed was 12.6% with the serum samples collected from suspected PPR cases showing significantly (p=0.000) higher seroprevalence (71.4%) than that in samples collected for investigation of other diseases (5.7%). Interviewed farmers were aware of PPR including clear description of clinical signs of the disease. Although farmers were aware of efforts made to control the disease, only 32% of them had their animals vaccinated against PPR. The low vaccination coverage suggests continued prevalence of PPR in the study area. It is concluded that there is limited capacity with respect to veterinary disease surveillance, reporting and control of transboundary and emerging diseases which need to be addressed in the country.