Miracle-dz/UniFAR-FTUs huggingface dataset:
Tomodensitometric and histological age‐related changes in the normal feline middle and inner ear

Deafness in cats may be due to acquired causes such as aging. Similar age‐related morphological changes in the cochlea have been noted in several animal species. However, little is known about the effects of age on the morphology of the middle and inner ear in cats. The aim of the present study was to compare these structures in middle‐aged and geriatric cats using computed tomography and histological morphometric analysis. Data were obtained from 28 cats, aged 3–18 years, with no hearing or neurological disorders. Computed tomography showed an increase in tympanic bulla (middle ear) volume with aging. Histological morphometric analysis revealed thickening of the basilar membrane and atrophy of the stria vascularis (inner ear) in older cats, similar to what has been observed in older humans and dogs. Nevertheless, histological procedures could be improved to provide more data for comparison with different forms of presbycusis in humans.
Active Aging Policies Targeting Health and Care During the of COVID-19 Pandemic: A Systematic Review and Thematic Analysis of Italian National and Regional Policies

A primary objective of active aging policies is to promote health and optimize care for individuals. In aging societies, the maintenance of good physical and mental health and the management of risk factors are of utmost importance. Few research studies have analyzed active aging policies related to health and care from a multi-level governance perspective. The aim of this study was to determine what national and regional policies in these domains existed in Italy. We conducted an inductive thematic analysis of health- and care-related policies on active aging, selected through a systematic review in 2019–2021. The analysis uncovered three themes at both the national and regional levels (health promotion and disease prevention, health monitoring, and informal caregivers) and two additional themes at the regional level (access to health and social care services, and mental health and well-being). According to the findings, COVID-19 partially influenced the evolution of active aging policies.
The physical determinants of maximal jumping time of flight in elite trampolining

ABSTRACT Time of flight (ToF) is an objective scoring component of elite trampolining, assessed in training by maximal jump tests. The aim of this study was to assess the relationship between physical floor based performance meaures and 20-maximum ToF. Thirty-two elite level gymnasts (13 senior; 19 junior) performed a battery of floor based tests and a 20-maximum jump test. Floor based tests included cycling peak power output, reactive strength index (RSI), unloaded countermovement jumps (CMJ), and loaded CMJ’s to construct a load-velocity profile for prediction of theoretical maximum force (CMJ F0). Very large and large, positive bivariate relationships were observed between CMJ F0 and ToF for the seniors (r = 0.85) and juniors (r = 0.56), respectively. Very large, positive bivariate relationships were observed between CMJ height and total ToF for both seniors (r = 0.74) and juniors (r = 0.77). Step-wise multiple regression analyses revealed CMJ F0 predicted 72% of ToF variability between seniors, and CMJ height (59%), 10 to 5 RSI (13%), and CMJ F0 (10%) predicting 82% of ToF variability between juniors. This suggests CMJ F0, lower limb maximal isometric capabilities, and CMJ height are important floor based predictors of maximal ToF in elite gymnasts. Highlights Trampolining is an Olympic sport, however, the determinants of maximal jumping (critical component of the overall score) are poorly understood. The relationship between floor based performance test metrics and 20-max time of flight performance was explored. Theoretical lower limb maximal isometric capabilities, as calculated by force velocity extrapolation, and CMJ height are important floor based tests and predictors of maximal ToF in senior and junior elite trampoline gymnasts. This information can be used to target specific, trainable physical qualities that can improve the determining factors such as lower limb maximal isometric force, and therefore have the potential to influence maximal ToF performance.
The effect of sequential dental visits on dental anxiety levels of paediatric patients.

AIM The aim of the present study is to evaluate the relationship between sequential visits in dental caries treatments and dental anxiety levels of paediatric patients through the use of anxiety scales and physiological measurements. METHODS A total of 224 children aged 5-8 years who needed at least two bilateral restorative dental caries treatments of the mandibular first primary molar was included in the study. The treatment duration was approximately 20 minutes and time span between the two appointments was a maximum of two weeks. The Wong-Baker FACES Pain Rating Scale (WBFPS) and The Modified Dental Anxiety Scale (MDAS) were used for subjective measurements and the objective measurement of dental anxiety was performed by measuring the heart rate using a portable pulse oximeter. Statistical analysis was carried out using the Statistical Package for the Social Sciences version 22 (IBM corp. Armonk, NY, USA). CONCLUSION The results of this study show a significant reduction in dental anxiety after sequental dental visits in children aged 5-8 years, which highlights the importance of the sequental visits in paediatric dentistry.
Establishment and impacts of emerald ash borer (Coleoptera: Buprestidae) parasitoids released at early- and post-invasion sites

Forest stands infested by emerald ash borer (EAB), Agrilus planipennis Fairmaire, experience extensive mortality of mature ash trees. Post-invasion woodlands commonly have a small contingent of mature lingering ash, an orphaned cohort of seedlings/saplings, and low EAB densities. To protect regenerating ash against rebounding EAB populations, a suite of biocontrol agents are being reared and released. USDA APHIS guidelines currently recommend the release of parasitoids into forests prior to overstory ash mortality at sites containing a variety of ash size classes and low to moderate but building EAB densities. To understand if biocontrol establishment and control of EAB is feasible in post-invasion sites, we assessed the establishment of parasitoids in 6 post-invasion forest stands in 2 regions of NY and compared EAB mortality in these stands to 2 regions where releases were conducted during the early-invasion phase. Results of parasitoid trapping indicates Tetrastichus planipennisi Yang established under both release strategies. Spathius galinae Belokobylskij & Strazanac was only released in post-invasion stands, where it was established successfully. Artificial EAB cohorts were established and life tables were constructed at 3 sites per region. EAB mortality due to T. planipennisi parasitism was similar under both release strategies 2 yr after release in post-invasion stands versus 8 yr after release in early-invasion stands. Combined mortality from T. planipennisi and woodpecker predation resulted in consistently low EAB reproductive rates. Future biocontrol releases could target forests identified as economically or ecologically important, regardless of whether EAB populations are increasing or have collapsed following initial invasion.
Cardiogenic shock: a major challenge for the clinical trialist

Purpose of review Cardiogenic shock (CS) results in persistently high short-term mortality and a lack of evidence-based therapies. Several trials of novel interventions have failed to show an improvement in clinical outcomes despite promising preclinical and physiologic principles. In this review, we highlight the challenges of CS trials and provide suggestions for the optimization and harmonization of their design. Recent findings CS clinical trials have been plagued by slow or incomplete enrolment, heterogeneous or nonrepresentative patient cohorts, and neutral results. To achieve meaningful, practice-changing results in CS clinical trials, an accurate CS definition, a pragmatic staging of its severity for appropriate patient selection, an improvement in informed consent process, and the use of patient-centered outcomes are required. Future optimizations include the use of predictive enrichment using host response biomarkers to unravel the biological heterogeneity of the CS syndrome and identify subphenotypes most likely to benefit from individualized treatment to allow a personalized medicine approach. Summary Accurate characterization of CS severity and its pathophysiology are crucial to unravel heterogeneity and identify the patients most likely to benefit from a tested treatment. Implementation of biomarker-stratified adaptive clinical trial designs (i.e., biomarker or subphenotype-based therapy) might provide important insights into treatment effects.
Electrospray Deposition of PEDOT:PSS on Carbon Yarn Electrodes for Solid-State Flexible Supercapacitors

The increasing demand for flexible electronic devices has risen due to the high interest in electronic textiles (e-textiles). Consequently, the urge to power e-textiles has sparked enormous interest in flexible energy storage devices. One-dimensional (1D) configuration supercapacitors are the most promising technology for textile applications, but often their production involves complex synthesis techniques and expensive materials. This work unveils the use of the novel electrospray deposition (ESD) technique for the deposition of poly(3,4-ethylenedioxythiophene)–poly(styrene sulfonate) (PEDOT:PSS). This deposition methodology on conductive carbon yarns creates flexible electrodes with a high surface area. The deposition conditions of PEDOT:PSS were optimized, and their influence on the electrochemical performance of a 1D symmetric supercapacitor with a cellulose-based gel as an electrolyte and a separator was evaluated. The tests herein reported show that these capacitors exhibited a high specific capacitance of 72 mF g–1, an excellent cyclability of more than 85% capacitance retention after 1500 cycles, and an outstanding capability of bending.
The Deciding Factors of Flow Direction in Lymphovenous Anastomosis for Extremity Lymphedema

Background: While using lymphovenous anastomosis (LVA) to treat extremity lymphedema, an antegrade lymphatic–to-venous flow is usually considered to indicate a functional and effective anastomosis. The authors analyzed the characteristics of lymphovenous anastomoses in patients with extremity lymphedema to look for the deciding factors of the flow direction. Methods: A total of 45 patients (15 arms and 42 legs) undergoing LVA for extremity lymphedema were reviewed. Only the anastomoses with intraoperatively confirmed patent flow or clear visualization of vessel lumens during anastomosis were included for analysis. Multivariate logistic regression was used to identify the contributing factors of intraoperative washout phenomenon or venous reflux. Results: A total of 105 eligible LVAs were included for analysis. Anastomosis with a more sclerotic lymphatic duct is statistically significantly associated with more venous reflux (OR, 2.82; P = 0.003). Larger diameter difference between lymphatic duct and recipient vein (OR, 12.8; P = 0.02) and less sclerotic lymphatic duct (OR, 0.47; P = 0.03) are statistically significantly associated with more washout phenomena. Conclusions: The deciding factors of flow direction in LVA are difference of diameters between lymphatic duct and recipient vein, and the severity of lymphosclerosis. To obtain favorable antegrade lymph-to-vein flow, a less sclerotic lymphatic duct with larger diameter and a recipient vein with smaller diameter should be chosen for anastomosis. CLINICAL QUESTION/LEVEL OF EVIDENCE: Risk, III.
Relationship between burnout levels of nurses and their circadian preference, sleep quality, and personality traits

ABSTRACT Occupational stress and burnout are widely encountered among many healthcare professionals, including nurses and doctors, as well as among members of other professions. For example, nurses, who have disrupted circadian rhythms, are seen to have sleep problems. In addition, their personality traits are also considered to be related with burnout. This study aimed to identify nurses’ circadian preference and personality traits along with their effects on sleep quality and their relationship with burnout. In this study, 211 nurses (40 male, 171 female) using the correlational model from quantitative research methods was used since the variables of morningness/eveningness, personality trait, sleep quality, and burnout were aimed to be investigated at once, without intervention, within the predictivity context of the relationship among them. When the scores obtained from the burnout scale were examined, it was observed that the emotional exhaustion and personal accomplishment subdimensions were so close to the median value and mean, while depersonalization was quite low compared to these sub-dimensions. The participants’ sleep quality was seen to be at the lowest step of the poor sleep quality class. When the scores obtained from the MESSI scale are examined, it is seen that the scores obtained from the morning affect dimension are above the median value, and the highest average according to the Five-Factor Personality Traits Scale is obtained in the subdimensions of agreeableness and conscientiousness. Female gender, constantly work at night, having a high number of weekly working hours increased burnout level. Additionally Evening chronotype, poor sleep quality, neuroticism, agreeableness, extroversion and conscientiousness personality traits were found to be associated with burnout in this study. In the study, being of different chronotypes, having other personality traits, and varying sleep quality scores were seen to affect the sub-dimensions of burnout.
Tenofovir versus entecavir on the prognosis of hepatitis B-related hepatocellular carcinoma after surgical resection: a randomised controlled trial

Background: Nucleot(s)ide analog treatment (entecavir (ETV) and tenofovir (TDF)) is reported to be associated with decreased tumor recurrence and death in hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) patients, yet further work is needed to evaluate the different efficacies of these two agents on the prognosis of early-stage HBV-related HCC patients after curative liver resection. Material and methods: From July 2017 to January 2019, 148 patients with HBV-related HCC who underwent curative liver resection were randomized to receive TDF (n=74) or ETV (n=74) therapy. The primary end point was tumor recurrence in the intention-to-treat population. Overall survival and tumor recurrence of patients were compared by multivariable-adjusted Cox regression and competing risk analyses. Results: During the follow-up with continued antiviral therapy, 37 (25.0%) patients developed tumor recurrence, and 16 (10.8%) patients died (N=15) or received liver transplantation (N=1). In the intention-to-treat cohort, the recurrence-free survival for the TDF group was significantly better than that for the ETV group (P=0.026). In the multivariate analysis, the relative risks of recurrence and death/liver transplantation for ETV therapy were 3.056 (95% CI: 1.015–9.196; P=0.047) and 2.566 (95% CI: 1.264–5.228; P=0.009), respectively. Subgroup analysis of the PP population indicated a better overall survival and RFS of patients receiving TDF therapy (P=0.048; hazard ratio (HR) =0.362; 95% CI: 0.132–0.993 and P=0.014; HR =0.458; 95% CI: 0.245–0.856). Additionally, TDF therapy was an independent protective factor against late tumor recurrence (P=0.046; (HR)=0.432; 95% CI: 0.189–0.985) but not against early tumor recurrence (P=0.109; HR =1.964; 95% CI: 0.858–4.494). Conclusion: HBV-related HCC patients treated with consistent TDF therapy had a significantly lower risk of tumor recurrence than those treated with ETV after curative treatment.
A PUZZLING PHENOMENON IN SEMIPARAMETRIC ESTIMATION PROBLEMS WITH INFINITE-DIMENSIONAL NUISANCE PARAMETERS

This note considers a puzzling phenomenon that is observed in some semiparametric estimation problems. In some cases, using estimated values of the nuisance parameters provides a more efficient estimator for the parameters of interest than does using the true values. This phenomenon takes place even in cases of semi-nonparametric models in which the nuisance parameters are infinite-dimensional and cannot be estimated at the parametric rate. We examine the structure and present the necessary and sufficient condition for the occurrence of this puzzle. We also provide a simple sufficient condition. It shows that the puzzle occurs when the term accounting for the effect of estimation of nuisance parameters is included in the tangent space. This condition is often satisfied when the estimating equation does not bring any restriction on the form of the nuisance parameters. Our simple sufficient condition can be applied to many important estimators.
Patient and nursing experience of flash glucose monitoring following kidney transplantation

Flash glucose monitoring (FGM) is increasingly used for blood glucose assessment due to ease of use and is now subsidized in Australia for blood glucose measurement for patients with Type 1 Diabetes Mellitus. Dysglycaemia is common following kidney transplantation and is associated with worse outcomes and there are data to support the use of FGM post‐transplant to better detect and manage changes in blood glucose levels. There is, however, no data on patient or staff perceptions of FGM, or resource implications in this setting. We prospectively evaluated patients and nursing staff experiences of FGM compared to traditional capillary glucose measurement in the immediate post‐transplant setting, along with resource utilization, cost of testing, staff time taken to test and accuracy. Twenty‐one kidney transplant recipients had a FGM sensor applied in the post‐operative period and results compared to capillary blood glucose monitoring (CBGM) measured at least four times a day. Six‐hundred‐fifty‐six glucose measurements were obtained, median per patient of 30 readings (IQR 10). Pearson's correlation between FGM and CBGM readings is 0.95 (p < .001). FGM readings were lower than CBGM by an average of 1.2 mmol/L (SD 0.7). Using a 5‐point preference questionnaire (with ratings varying from strongly disagree‐strongly agree), both patients and nurses were highly satisfied with the usability and convenience of FGM, with all preferring FGM over CBGM. Average time to perform FGM was 3.6 s versus 64 s for CBGM. In average, cost of FGM was $58 less than traditional testing per patient. FGM is an accurate, convenient and cost‐effective tool that may support optimal management of glycaemic control in the post‐transplant period.
Epidemiology of perinatal depression in Italy: systematic review and meta-analysis.

INTRODUCTION This review aims to synthesise the studies that have estimated the prevalence of perinatal depression in Italy, summarising the results of the existing literature based on their quality. MATERIALS AND METHODS Systematic searches were conducted in four major databases, and a random effect meta-analysis was performed to achieve the pooled variance of perinatal depression. RESULTS The pooled prepartum risk of depression prevalence was 20.2% (CI 95% 15.3-24.5) while the postpartum risk of depression prevalence was 27.5% (CI 95% 17.8-37.3) for an Edinburgh Postnatal Depression Scale (EPDS) cut-off score ≥9 and 11.1% (CI 95% 6.0-16.2) for an EPDS cut-off score ≥12. Significant publication bias was found and was determined by the presence of a small study with a low prevalence and a large study with a high prevalence. CONCLUSION The prevalence of perinatal risk of depression is similar to that reported in other countries. The high prevalence of prepartum risk suggests the need to activate specific prevention actions during this period.
Nutrition impact symptoms in head and neck cancer during radiotherapy: a longitudinal study

Abstract Background Patients with head and neck cancer (HNC) receiving radiotherapy (RT) are at a high risk of weight loss (WL) due to a variety of nutrition impact symptoms (NISs). Objective This prospective observational study aimed to investigate the consecutive changes of NIS during RT and analyzed its impact on body weight. Materials and methods The Head and Neck patient Symptom Checklist was adopted to evaluate NIS. NIS, body weight, hemoglobin and lymphocyte of 94 participants were assessed at four time points during RT and the treatment outcomes were assessed at the time of 12 months after the completion of RT. Generalised estimation equations (GEEs) and Kendall’s tau-b were used for statistical analysis. Results Our study found that pain, taste changes and dry mouth were the most common NIS, reported by >90% of patients and had higher interference scores (more than 85% >2) at the end of RT. The average WL was 4.22 ± 3.59 kg after treatment, and more than two-thirds of patients (67.02%, 64/94) experienced significant WL of >5%. Lack of energy, vomiting and taste changes impacted WL significantly (p < .05). Taste changes were also associated with hemoglobin and lymphocyte reduction (p = .018, p < .001). WL correlated negatively with tumor response (p = .031). Conclusions and significance In patients with HNC, taste changes, pain, dry mouth and vomiting were seen. Nutritional intervention applied as early as the first 10 days of RT could help to change the nutrition status and improve the clinical outcomes.
Irisin attenuates pyroptosis in high glucose-induced pancreatic beta cells via the miR-133a-3p/FOXO1 axis.

INTRODUCTION Irisin is closely related to type 2 diabetes mellitus (T2DM) and other metabolic diseases. It can improve the homeostasis of T2DM. MiR-133a-3p is decreased in the peripheral blood of patients with T2DM. Forkhead box protein O1 (FOXO1) is widely expressed in beta-cells and affects the occurrence of diabetes through transcriptional regulation and signalling pathway regulation. MATERIAL AND METHODS The miR-133a-3p inhibitor was constructed to verify the effect of irisin on pyroptosis through miR-133a-3p. Next, we predicted the presence of targeted binding sequences between FOXO1 and miR-133a-3p by bioinformatics software, which was then confirmed with a double fluorescence assay. Finally, the FOXO1 overexpression vector was used to further verify the effect of irisin through the miR-133a-3p/FOXO1 axis. RESULTS We first observed that irisin inhibited the protein levels of N-terminal gasdermin D (GSDMD-N) and cleaved caspase-1 and the secretion of interleukins (IL): IL-1beta and IL-18 in Min6 cells treated with high glucoes (HG). Irisin inhibited pyroptosis of Min6 cells treated with HG by reinforcing miR-133a-3p. Then, FOXO1 was validated to be the target gene of miR-133a. Both miR-133a-3p inhibitor and overexpression of FOXO1 restrained the force of irisin on pyroptosis in HG-induced Min6 cells. CONCLUSION We explored the protective effect of irisin on HG-induced pyroptosis of islet b-cells in vitro and explained its mechanism of inhibiting pyroptosis through the miR-133a-3p/FOXO1 axis, to provide a theoretical basis for finding new molecular targets to delay beta-cell failure and the treatment of T2DM.