Miracle-dz/UniFAR-FTUs huggingface dataset:
Inhibition of GPR39 restores defects in endothelial cell–mediated neovascularization under the duress of chronic hyperglycemia: Evidence for regulatory roles of the sonic hedgehog signaling axis

Significance GPR39 is an orphan GPR whose physiological ligand and intracellular pathways in ECs remain poorly characterized. Our data indicate that inhibition of GPR39 protects EC functions by enhancing SHH signaling in aortic ECs. Understanding the potential cross-talk between GPR39 activation and SHH signaling in hyperglycemia may form the basis for developing therapeutic approaches to target cardiovascular complications in diabetic patients. Our studies also revealed that genetic ablation of GPR39 significantly improves revascularization after ischemia in vivo in a type 2 diabetic mouse model. Our studies open an avenue to preserving endothelial function and vascular health by targeting GPR39. The development of pharmacological or genetic agents to block GPR39 in ECs may be a fruitful area of future research.
Evaluating Portuguese Public Hospitals Performance: Any Difference before and during COVID-19?

COVID-19 is a well-known respiratory disease that has spread worldwide since January 2020, causing many deaths and massive pressure on health systems. This pandemic’s appearance compromised health service sustainability and quality as many procedures were postponed or canceled, with an expected increase of adverse events like nosocomial infections, in-hospital deaths, and the worsening of the patient’s clinical status. For instance, the year 2020 featured an increase in undesirable results in Portugal: a rise of 10% in delayed first medical appointments, 0.02% in avoidable bloodstream infections, and more than 100 post-operative pulmonary embolisms and septicemia cases per 100,000 inpatients. Therefore, assessing whether the healthcare providers’ performance has changed is paramount. In this case, we evaluated public hospitals in Portugal. To this end, we developed a network data envelopment analysis model relating to efficiency and effectiveness. We observed consistent drops in efficiency when the pandemic started, followed by a recovery to levels above the pre-pandemic ones. Regarding effectiveness, we observed a positive trend during the evaluated period. We conclude that, apart from the great resilience of public healthcare providers, the Portuguese state was unprepared for a pandemic like COVID-19, but still the actions taken (including massive vaccination) were beneficial.
A Comparison of Radar Reflectivity Estimates of Rainfall from Collocated Radars

Abstract Radar reflectivity–based rainfall estimates from collocated radars are examined. The usual large storm-to-storm variations in radar bias and high correlation between radar estimates and rain gauge observations are found. For three storms in Colorado, the radar bias factor (the ratio between gauge observations and radar estimates) with the National Center for Atmospheric Research’s S-band, dual-polarization radar (S-Pol) varied from 0.78 (an overestimate with radar) to 1.88. The correlation coefficient between gauge and radar amounts varied from 0.78 to 0.90. For a collocated Weather Surveillance Radar-1988 Doppler (WSR-88D), the bias factor varied from 0.56 to 1.49, and the correlation between gauge and radar amounts ranged from 0.77 to 0.87. In Kansas, bias factors varied from 0.86 to 1.41 for S-Pol (10 storms) and 0.82 to 1.71 for a paired WSR-88D (9 storms). The spread in correlation coefficients was 0.82–0.95 for S-Pol and 0.87–0.95 for the WSR-88D. Correspondence between the radar-derived ra.
New Light-Green Thermally Activated Delayed Fluorescence Polymer Based on Dimethylacridine-Triphenyltriazine Light-Emitting Unit and Tetraphenylsilane Moiety as Non-Conjugated Backbone

In the search for solution-processable TADF materials as a light emitting layer for OLED devices, polymers have attracted considerable attention due to their better thermal and morphological properties in the film state with respect to small molecules. In this work, a new polymer (p-TPS-DMAC-TRZ) with thermally activated delayed fluorescence (TADF) light-emitting characteristics was prepared from a conjugation-break unit (TPS) and a well-known TADF core (DAMC-TRZ). This material was designed to preserve the photophysical properties of DAMC-TRZ, while improving other properties, such as thermal stability, promoted by its polymerization with a TPS core. Along with excellent solubility in common organic solvents such as toluene, chloroform and THF, the polymer (Mn = 9500; Mw = 15200) showed high thermal stability (TDT5% = 481 °C), and a Tg value of 265 °C, parameters higher than the reference small molecule DMAC-TRZ (TDT5% = 305 °C; Tg = 91 °C). The photoluminescence maximum of the polymer was centered at 508 nm in the solid state, showing a low redshift compared to DMAC-TRZ (500 nm), while also showing a redshift in solution with solvents of increasing polarity. Time-resolved photoluminescence of p-TPS-DMAC-TRZ at 298 K, showed considerable delayed emission in solid state, with two relatively long lifetimes, 0.290 s (0.14) and 2.06 s (0.50), and a short lifetime of 23.6 ns, while at 77 K, the delayed emission was considerably quenched, and two lifetimes in total were observed, 24.6 ns (0.80) and 180 ns (0.20), which was expected from the slower RISC process at lower temperatures, decreasing the efficiency of the delayed emission and demonstrating that p-TPS-DMAC-TRZ has a TADF emission. This is in agreement with room temperature TRPL measurements in solution, where a decrease in both lifetime and delayed contribution to total photoluminescence was observed when oxygen was present. The PLQY of the mCP blend films with 1% p-TPS-DMAC-DMAC-TRZ as a dopant was determined to be equal to 0.62, while in the pure film, it was equal to 0.29, which is lower than that observed for DMAC-TRZ (0.81). Cyclic voltammetry experiments showed similarities between p-TPS-DMAC-TRZ and DAMC-TRZ with HOMO and LUMO energies of −5.14 eV and −2.76 eV, respectively, establishing an electrochemical bandgap value of 2.38 eV. The thin film morphology of p-TPS-DMAC-TRZ and DMAC-TRZ was compared by AFM and FE-SEM, and the results showed that p-TPS-DMAC-TRZ has a smoother surface with fewer defects, such as aggregations. These results show that the design strategy succeeded in improving the thermal and morphological properties in the polymeric material compared to the reference small molecule, while the photophysical properties were mostly maintained, except for the PLQY determined in the pure films. Still, these results show that p-TPS-DMAC-TRZ is a good candidate for use as a light-emitting layer in OLED devices, especially when used as a host-guest mixture in suitable materials such as mCP.
Excitation collision strengths, cross-sections and rate coefficients for O V, Si XI, Fe XXIII and Mo XXXIX by electron impact (1s22s2- 1s22s2p- 1s22p2 transitions)

Excitation collision strengths, cross-sections and rate coefficients by electron impact are calculated for the transitions among 1s22s2, 1s22s2p, 1s22p2 levels of Be-like system of O V, Si XI, Fe XXIII and Mo XXXIX ions by Coulomb-Born approximation with exchange including relativistic effect and configuration interactions. The theoretical method for calculation is described and the results are compared with previous calculations. Numerical data and comparison are presented in tables as well as in figures. Two kinds of fitting formulae for cross-sections and rate coefficients are discussed.
Nutritional properties of spectacled caiman (Caiman yacare) meat marketed as part of a wildlife management strategy in the Beni river basin

We determined the nutritional quality of yacare meat (Caiman yacare) in the Beni river basin. Commercial cut samples were obtained from the tails of four males harvested as part of a management plan implemented in the Tacana Indigenous Territory. This plan guarantees long-term sustainability of caiman hunting. pH analysis, the Eber test, and the ammoniacal nitrogen test suggest that the meat was of good quality, processed properly, and free of contamination. Nutritional analyses suggest that yacare meat is a healthy alternative for human consumption, as it has a high protein value (23.02 g/100g) and low fat concentration (0.67g/100g). Yacare meat has a high concentration of minerals such as phosphorus (227.53 g) and calcium (11.84 g), both beneficial for memory and cardiovascular health. Caiman meat can be considered as a valuable nutritional supplement in human diets both in urban and rural areas
Ameliorative Effect of Citrus Lemon Peel Extract and Resveratrol on Premature Ovarian Failure Rat Model: Role of iNOS/Caspase-3 Pathway

Premature ovarian failure (POF) is described as a loss of oocytes and the absence of folliculogenesis and is considered an adverse effect of chemotherapeutic drugs, which leads to infertility. Subsequently, the existing inquiry was achieved by exploring the potential suspicious influences of lemon peel extract (LPE), and resveratrol (RES) on cyclophosphamide (CPA) induced-POF. The results showed that CPA-induced POF significantly decreased serum estradiol (E2) and progesterone levels, along with a considerable rise in serum luteinizing hormone (LH) and follicle-stimulating hormone (FSH) levels. Moreover, CPA administration to rats significantly increased the serum level of Malondialdehyde (MDA) and significantly lowered the levels of reduced glutathione (GSH) and superoxide dismutase (SOD); in addition, it increased nuclear factor kappa B (NF-κB) levels, tumor necrosis factor-α (TNF-α), as well as cyclooxygenase 2 (COX-2) with the spread expression of inducible nitric oxide synthase (iNOS) mRNA levels and caspase-3 (Casp3) levels in ovarian tissues versus the control rats. However, treatment with LPE and RES suppressed the triggering of NF- κB pathways, evidenced by a considerable reduction in Casp3 & iNOS mRNA expression level and significant ameliorative effects in all evaluated parameters, as confirmed by the histological and immunohistochemical investigation when comparing the model group. In overall findings, both lemon peel extract and resveratrol can mitigate the adverse effects of CPA-induced POF. Most crucially, its combination therapy is a promising pharmacological agent for this disease.
Scaling Laws and Luminosity Segregation

We debate how the scaling properties of the angular correlation function w(θ) depend on luminosity segregation. Under the approximation that there is no deviation from Euclidean geometry and no evolution, we find that the scaling with catalog depth (D*) is the same both for a luminosity (L) independent clustering length (r0) and for a generic dependence of r0 on L. Recent angular data, however, extend to depths where the above approximation is unsuitable and the simple scaling w ∝ D should be modified. We find that such modifications depend on the shape of the L-dependence of r0 and are indeed different depending on whether luminosity segregation is or is not considered. In particular, we find that a luminosity segregation as observed at z = 0 causes effects of the same order as varying the rate of clustering evolution. For the sake of example, we apply our expressions to available angular galaxy data in the B- and R-bands and show that significant constraints on the evolution of clustering can already be found with public data.
The Sensitivity of Stationary Waves to Variations in the Basic State Zonal Flow

Abstract A linear, primitive equation stationary wave model having high vertical and meridional resolution is used to examine the sensitivity of orographically forced (primarily by Himalayas) stationary waves at middle and high latitudes to variations in the basic state zonal wind distribution. We find relatively little sensitivity to the winds in high latitude but remarkable sensitivity to small variations in the subtropical jet. Fluctuations well within the range of observed variability in the jet can lead to large variations in the stationary waves of the high latitude stratosphere, and to large changes even in tropospheric stationery waves. Implications for both sudden warmings and large-scale weather are discussed.
Angular Momentum Transfer in Star-Disk Encounters: The Case of Low-Mass Disks

A prerequisite for the formation of stars and planetary systems is that angular momentum be transported in some way from the inner regions of the accretion disk. Tidal effects may play an important part in this angular momentum transport. Here the angular momentum transfer in a star-disk encounter is investigated numerically for a variety of encounter parameters in the case of low-mass disks. Although good agreement is found with analytical results for the entire disk, the loss inside the disk can be up to an order of magnitude higher than previously assumed. The differences in angular momentum transport caused by secondary stars on hyperbolic, parabolic, and elliptical paths are shown, and it is found that a succession of distant encounters might be equally, if not more, successful in removing angular momentum than a single close encounter.
Iconic Arable Weeds: The Significance of Corn Poppy (Papaver rhoeas), Cornflower (Centaurea cyanus), and Field Larkspur (Delphinium consolida) in Hungarian Ethnobotanical and Cultural Heritage

There are an increasing number of initiatives that recognize arable weed species as an important component of agricultural biodiversity. Such initiatives often focus on declining species that were once abundant and are still well known, but the ethnographic relevance of such species receives little recognition. We carried out an extensive literature review on the medicinal, ornamental, and cultural applications of three selected species, Papaver rhoeas, Centaurea cyanus, and Delphinium consolida, in the relevant Hungarian literature published between 1578 and 2021. We found a great diversity of medicinal usages. While P. rhoeas stands out with its sedative influence, D. consolida was mainly employed to stop bleeding, and C. cyanus was most frequently used to cure eye inflammation. The buds of P. rhoeas were sporadically eaten and its petals were used as a food dye. All species fulfilled ornamental purposes, either as garden plants or gathered in the wild for bouquets. They were essential elements of harvest festivals and religious festivities, particularly in Corpus Christi processions. P. rhoeas was also a part of several children’s games. These wildflowers were regularly depicted in traditional Hungarian folk art. In poetry, P. rhoeas was used as a symbol of burning love or impermanence; C. cyanus was frequently associated with tenderness and faithfulness; while D. consolida regularly emerged as a nostalgic remembrance of the disappearing rural lifestyle. These plants were also used as patriotic symbols in illustrations for faithfulness, loyalty, or homesickness. Our results highlight the deep and prevalent embeddedness of the three iconic weed species studied in the folk culture of the Carpathian Basin. The ethnobotanical and cultural embeddedness of arable weed species should also be considered when efforts and instruments for the conservation of arable weed communities are designed.
Realized Kernels in Practice: Trades and Quotes

Realized kernels use high-frequency data to estimate daily volatility of individual stock prices. They can be applied to either trade or quote data. Here we provide the details of how we suggest implementing them in practice. We compare the estimates based on trade and quote data for the same stock and find a remarkable level of agreement. Copyright The Author(s). Journal compilation Royal Economic Society 2009
Bioactive Substances of Potato Juice Reveal Synergy in Cytotoxic Activity against Cancer Cells of Digestive System Studied In Vitro

More and more literature data indicate the health-promoting effect of potato juice (PJ). However, to date, it has not been precisely explained which of the many compounds present in PJ exhibit biological activity. The work aimed to establish the antiproliferative effect of gastrointestinal digested PJ and the products of its processing. Fresh PJs derived from three edible potato varieties, industrial side stream resulting from starch production, partially deproteinized PJ derived from feed protein production line, and three different potato protein preparations subjected to digestion in the artificial gastrointestinal tract were used in this study. The cytotoxic potential of glycoalkaloids (GAs), phenolic acids, digested PJ, and products of PJ processing was determined in human normal and cancer cells derived from the digestive system. The results showed that GAs exhibit concentration-dependent cytotoxicity against all analyzed cell lines. In contrast, phenolic acids (caffeic, ferulic, and chlorogenic acid) do not show cytotoxicity in the applied cell lines. A correlation between cytotoxic potency and GAs content was found in all PJ products studied. The most potent effects were observed under treatment with deproteinized PJ, a product of industrial processing of PJ, distinguished by the highest effective activity among the fresh juice products studied. Moreover, this preparation revealed a favorable cytotoxicity ratio towards cancer cells compared to normal cells. Statistical analysis of the obtained results showed the synergistic effect of other bioactive substances contained in PJ and its products, which may be crucial in further research on the possibility of using PJ as a source of compounds of therapeutic importance.
Craniolacunia and the Development of the Fetal Calvaria: An Autopsy Series With Clinical and Histological Analysis

Background: Craniolacunia, also known as lückenschädel, is a congenital abnormality of the calvaria featuring well-circumscribed areas of marked thinning, interspersed with more-normal bone. It is most commonly associated with myelomeningocele and/or Chiari 2 malformation. Methods: Records, photographs, and histologic sections were reviewed from 13 autopsy cases with craniolacunia. To investigate normal calvarial development, 23 parietal bone samples from fetuses/infants of 16–42 weeks gestation were examined. Results: Parietal bone development had reproducible morphologic stages. Bone thickness increased with gestational age, while osteoblast numbers decreased. Craniolacunia was mainly seen in neonates. Five patients had Chiari 2 malformation, 1 had hydrocephalus, and 2 had other structural CNS abnormalities. One had trisomy 18. Four had no congenital abnormalities. Two sustained intrapartum skull fractures. Histologic sections were available in 5 cases. Lacunae in term infants had architecture similar to normal calvaria at 16–20 weeks. Adjacent bone had age appropriate architecture but increased osteoblast numbers. Conclusions: This is the largest autopsy series of craniolacunia and first systematic histologic analysis of craniolacunia and the developing fetal calvaria. Decreased cerebrospinal fluid pressure, due to myelomeningocele or other structural abnormality, may promote craniolacunia development. The risk of intrapartum fracture through lacunae emphasizes the continued clinical relevance of this diagnosis.
Smart Grids as product-service systems in the framework of energy 5.0 - a state-of-the-art review

Aim: This work explores the opportunities and challenges associated with the integration of Product Service Systems (PSS) into Smart Grids (SGs) with the aim of improving manufacturing and production systems’ sustainability under the Society 5.0 framework. Methods: A bibliometric analysis was conducted to examine the existing bibliographic material and identify the primary scientific directions for this research area. The aim was to provide a thorough understanding of the research problems and perform an in-depth analysis of the distinctive aspects of development of the scientific research in this field and visualize the results with VOS viewer tool. Results: Industry, society, and academia are being reshaped and reorganized to integrate new information and communications technology (ICT) to enable complete digitization and digitalization of their infrastructures. This trend is driven by the need for more resilient, environmentally sustainable, and human-centric systems, as indicated by the terms Industry 5.0 and Society 5.0. Electrical power generation and distribution currently are critical issues for society. In this context, SGs are examined from the perspective of product-service systems (PSSs). The key enabling technologies are discussed and a technical discussion based on presentation of implemented frameworks follows. Conclusion: Intelligent societies will become the new reality. It is necessary to adapt existing infrastructures toward human centricity, resilience, and sustainability. SGs require further development, with several challenges still to be addressed. However, engineers have several technologies available, including blockchain and PSSs, to promote client activity in societal infrastructures.
Spectral absorption properties of colored dissolved organic matter (CDOM) and total suspended matter (TSM) of inland waters

Spectral absorption properties of total suspended matter (TSM) and colored dissolved organic matter (CDOM) are important for the use of the bio-optical model to estimate water quality parameters. This study aims to investigate the variation in the absorption coefficients of TSM and CDOM of inland waters. A total of 92 water samples were collected from Shitoukoumen Reservoir and Songhua Lake in Northeast China, analyzed for TSM and Chl-a, and measured for the absorption coefficient of TSM, CDOM and total pigments using a laboratory spectrophotometer. The absorption coefficient of TSM has been decomposed for phytoplankton and inorganic sediments. The results show that for Shitoukoumen Reservoir, CDOM has strong absorptions with shallow absorption slopes (i.e., the coefficient S in a(λ)=a(λ0)exp[-S(λ- λ0)]) and large absorption at 355 nm; and for Songhua Lake, CDOM follows similar spectral absorption curves but less variation in the S value. The results also show TSM has the average absorption coefficient 5.7 m-1 at 440 nm and 0.93 m-1 at 675 nm, and their concentration is well correlated to TSM with R2 larger than 0.85 at 440 nm over both Songhu Lake and Shitoukoumen Reservoir. In summer, CDOM was mainly terrigenous and had a high proportion of humic acid derived from the decomposition of phytoplankton and there were no obvious difference of S value. The results indicate that inorganic sediments contributed much more absorption than phytoplankton pigments in Shitoukoumen Reservoir than that in Songhua Lake, and there is strong association of TSM concentration to absorption coefficient at 440 nm.
Prevalence, Clinico-Bacteriological Profile, and Antibiotic Resistance of Symptomatic Urinary Tract Infections in Pregnant Women

Background: Urinary tract infection (UTI) is a common complication in pregnancy. The prevalence varies between countries. This research aims at estimating the prevalence, clinico-bacteriological profile, antibiotic resistance, and risk factor analysis of symptomatic UTI in pregnancy. Method: This is a prospective observational study conducted at the Abdullah Bin Omran Hospital, RAK, UAE, from March 2019 to February 2020. All pregnant women attending the antenatal clinic during this period were given a pre-validated questionnaire for the symptoms of UTI. In symptomatic patients, urine was sent for microscopy, culture, and sensitivity. Women were treated for UTI and were followed up for the rest of the pregnancy. Data analysis was performed by SPSS software version 24 using descriptive statistics and comparisons with significance at a p-value of <0.05. Results: The prevalence of symptomatic UTI was 17.9%. E.coli was the commonest isolate followed by Group B streptococcus. The commonest symptom reported was loin pain and the most common risk factor was diabetes. Women with risk factors are significantly more likely to have culture-positive UTIs. Most of the pathogens were sensitive to cefuroxime and benzyl penicillin. Risk of preterm labor was higher. Conclusions: Regular antenatal care and routine urine testing in all visits are recommended for early detection and treatment of UTI.