Miracle-dz/UniFAR-FTUs huggingface dataset:
Magnetized relativistic jets and long-duration GRBs from magnetar spin-down during core-collapse supernovae

We use ideal axisymmetric relativistic magnetohydrodynamic simulations to calculate the spin-down of a newly formed millisecond, B ∼ 10 15 G, magnetar and its interaction with the surrounding stellar envelope during a core-collapse supernova (SN) explosion. The mass, angular momentum and rotational energy lost by the neutron star are determined self-consistently given the thermal properties of the cooling neutron star's atmosphere and the wind's interaction with the surrounding star. The magnetar drives a relativistic magnetized wind into a cavity created by the outgoing SN shock. For high spin-down powers (∼10 51 ―10 52 erg s ―1 ), the magnetar wind is superfast at almost all latitudes, while for lower spin-down powers (∼10 50 erg s ―1 ), the wind is subfast but still super-Alfvenic. In all cases, the rates at which the neutron star loses mass, angular momentum and energy are very similar to the corresponding free wind values (≤30 per cent differences), in spite of the causal contact between the neutron star and the stellar envelope. In addition, in all cases that we consider, the magnetar drives a collimated (∼5―10°) relativistic jet out along the rotation axis of the star. Nearly all of the spin-down power of the neutron star escapes via this polar jet, rather than being transferred to the more spherical SN explosion. The properties of this relativistic jet and its expected late-time evolution in the magnetar model are broadly consistent with observations of long duration gamma-ray bursts (GRBs) and their associated broad-lined Type Ic SN.
Optimal Inference Methods in Linear Models with Change-points

In this dissertation, we consider an estimation problem of the regression coefficients in both multiple regression model and multivariate multiple regression model with several unknown change-points. More precisely, we consider the cases where the target parameters (vectors or matrices) are suspected to satisfy some restrictions. In particular, we generalize in four ways, some recent statistical methods in the literatures. First, we relax some assumptions about the dependance structure of the noise and the regressors given in recent literature. Namely, in this dissertation, the dependance structure is as weak as that of an L-mixingale arrays of size -1/2. Second, under such weak assumptions, we derive the joint asymptotic normality between the RE and UE. Third, in the context of change-points models, the estimation problem of a vector of the regression coefficients is extended to that of a matrix of the regression coefficients. Fourth, we propose a class of estimators which includes as a special cases shrinkage estimators (SEs) as well as the unrestricted estimator (UE) and the restricted estimator (RE). We also derive a more general condition for the SEs to dominate the UE in mean square error. To this end, we generalize some identities for the evaluation of the bias and risk functions of shrinkage-type estimators (vectors or matrices). As illustrative example, our method is applied to the “gross domestic product” data set of 10 countries including USA, Canada, UK, France and Germany. The simulation results corroborate our theoretical findings.
The Effects of Prostate Cancer Treatment on Role-In-Sex in Gay and Bisexual Men: Mixed Methods Results from the Restore-1 and Restore-2 Studies

ABSTRACT Gay and bisexual men (GBM) with prostate cancer experience worse sexual and mental health outcomes following prostate cancer treatment than heterosexual men. Emerging evidence suggests that GBM may change their role-in-sex in response to treatment effects. The purpose of this study was to describe the impact of prostate cancer treatment on role-in-sex, to estimate the prevalence of such changes, and to determine the impact on quality of life and mental health. We conducted semi-structured interviews with 30 sexual minority prostate cancer patients. Then, we recruited 401 gay and bisexual prostate cancer patients into a study assessing the effects of rehabilitation. Qualitative data were analyzed using descriptive thematic analysis. Differences in quality of life and mental health outcomes were analyzed using multivariate analyses of variance. Prostate cancer treatment resulted in loss of role-in-sex for many patients. When changes in role-in-sex occurred, the shifts were predominantly from tops to bottoms. Those with a current top role-in-sex had significantly better sexual and mental health outcomes than either versatiles or bottoms. Clinical implications include the need for providers to ask about role-in-sex in order to address disparities in health outcomes by sexual orientation and to provide culturally appropriate care to sexual minority patients.
Prevalence and Characteristics of Salmonella spp. Isolated from Raw Chicken Meat in the Republic of Korea

In this study, we sought to investigate the various characteristics of Salmonella spp. isolated from raw chicken meats available in Korean markets. The data collected, such as food source of isolation, sampling information, serotype, virulence, and genetic profile including sequence type, were registered in the database for further comparative analysis of the strains isolated from the traceback investigation samples. To characterize serotype, virulence and gene sequences, we examined 113 domestically distributed chicken meat samples for contamination with Salmonella spp. Phylogenetic analysis was conducted on 24 strains (21.2%) of Salmonella isolated from 113 commercially available chicken meats and by-products, using pulsed-field gel electrophoresis (PFGE) and multilocus sequence typing (MLST). Serotyping of the isolated Salmonella spp. revealed S. Enteritidis in 11 strains (45.8%), S. Virchow in 6 strains (25%), S. Montevideo in 2 strains (8.3%), S. Bsilla in 2 strains (8.3%), S. Bareilly in 1 strain (4.2%), S. Dessau in 1 strain (4.2%), and S. Albany in 1 strain (4.2%). The genetic correlation indicated that 24 isolated strains were classified into 18 clusters with a genetic similarity of 64.4-100% between them. Eleven isolated S. Enteritidis strains were classified into 9 genotypes with a sequence identity of 74.4%, whereas the most distantly related S. Virchow was divided into five genotypes with 85.9% identity. Here, the MLST analysis indicated that the major Sequence Type (ST) of the Salmonella spp. isolated from domestic chicken sold in Chungcheong Province belongs to the ST 11 and 16, which differs from the genotype of Salmonella isolated from imported chicken. The differential sequence characteristics can be a genetic marker for identifying causative bacteria for epidemiological investigations of food poisoning.
Four organosulfur compounds from the seeds of Capsella bursa-pastoris and their anti-inflammatory activities

Abstract Phytochemical investigation of the seeds of Capsella bursa-pastoris led to the isolation of four organosulfur compounds. There were two new compounds, 10-methylsulfinyl-decanamide (1) and 11-methylsulfinyl-undecanamide (2), along with two known compounds (3 − 4), which all have a sulfoxide group and an amide or a nitrile group. Their chemical structures were elucidated by analysing UV, IR, ESI-MS and NMR spectroscopy. In addition, compounds 1 − 4 were evaluated for their anti-inflammatory activities by using LPS-induced RAW 264.7 cells. Compounds 1 − 4 exhibited potential anti-inflammatory activities on NO release characterised by decreasing the mRNA expression levels of inducible NO synthase (iNOS), cytokines cyclooxygenase-2 (COX-2) and interleukin 6 (IL-6). Graphical Abstract
Silent Pulmonary Embolism in Deep Vein Thrombosis: Relationship and Risk Factors

Purpose This study aimed to evaluate risk factors for silent pulmonary embolism (PE) in symptomatic deep vein thrombosis (DVT) and investigate the relationship between DVT and silent PE. Methods This was a single-centre, retrospective cohort study. Between 5 January 2015 and 31 December 2021, consecutive patients with symptomatic DVT received CT pulmonary angiography and CT venography were analyzed. Patient demographics, comorbidities, risk factors, and image findings were analyzed. The group differences were compared using a Chi-square test, Fisher's exact test, independent t test, or Mann-Whitney U test. Multivariant regression was used to determine predictive factors for silent PE. Results A total of 355 patients (mean age, 60.5 ± 16.6 years) were included. The incidence of silent PE was 43.1%. The main or lobar pulmonary arteries were affected in 53.6% of patients, which is more often found in iliofemoral DVTs (56.6% vs 26.7%, p = .027). The multivariant analysis showed male patients (p = .042; OR 1.59; 95% CI, 1.02–2.50), inferior vena cava involvement (p = .043; OR 1.81; 95% CI, 1.02–3.20) and D-dimer value > 3.82 μg/ml (p < .001; OR 2.32; 95% CI, 1.43–3.77) were risk factors for silent PE. Unilateral DVT patients with ipsilateral iliac vein compression had a lower incidence of silent PE (28.8% vs 52.9%, p < .001). Conclusion Iliofemoral DVT was associated with a more proximal PE. The male patients, inferior vena cava involvement, and D-dimer > 3.82 μg/ml were risk factors for silent PE. Ipsilateral iliac vein compression reduced the incidence of silent PE.
Facing ambiguity: Social threat sensitivity mediates the association between peer victimization and adolescent anxiety.

Peer victimization is a developmentally salient stressor that elevates adolescents' risk for anxiety disorders. However, modifiable mechanisms that explain this link and can be targeted via therapeutic interventions remain poorly understood. Drawing from psychobiological models implicating aberrant threat sensitivity in the development and maintenance of psychopathology, the current study investigated sensitivity to peer-related social threats as a mechanism underlying the association between peer victimization and anxiety. A sample of 197 dyads of early adolescents (M age = 12.02; 46% female) and parents/guardians (M age = 41.46; 90% female) completed online surveys assessing peer victimization, sensitivity to potential (i.e., ambiguous) social threats, and anxiety. Controlling for potentially confounding demographic and psychosocial factors, both self- and parent-reported peer victimization were positively associated with adolescent anxiety symptoms. Additionally, there were significant indirect effects from self- and parent-reported peer victimization to anxiety via social threat sensitivity. Supplemental analyses indicated unique effects of covert, but not overt, peer victimization on social threat sensitivity and anxiety. The findings provide initial evidence that peer victimization experiences lower adolescents' threshold for interpreting threats in ambiguous social situations, which contributes to heightened anxiety. These results implicate social threat sensitivity as a potential therapeutic target for interrupting links from peer victimization to psychological distress.
Show me you care: A patient‐ and family‐reported measure of care experiences in early psychosis services

Despite their emphasis on engagement, there has been little research on patients' and families' experiences of care in early intervention services for psychosis. We sought to compare patients' and families' experiences of care in two similar early psychosis services in Montreal, Canada and Chennai, India. Because no patient‐ or family‐reported experience measures had been used in a low‐ and middle‐income context, we created a new measure, Show me you care. Here we present its development and psychometric properties.
Limited value of neutrophil-to-lymphocyte ratio and serum creatinine as point-of-care biomarkers of disease severity and infection mortality in patients hospitalized with COVID-19

Introduction In hospitalized COVID-19, neutrophil-to-lymphocyte ratio (NLR) and serum creatinine is sometimes measured under assumption they predict disease severity and mortality. We determined the potential value of NLR and serum creatinine as predictors of disease severity and mortality in COVID-19. Methods Prospective cohort study of COVID-19 patients admitted to premier COVID-19 treatment hospitals in Ethiopia. Predictive capability of biomarkers in progression and prognosis of COVID-19 was analyzed using receiver operating characteristics. Survival of COVID-19 patients with different biomarker levels was computed. Logistic regression assessed associations between disease severity and mortality on NLR and serum creatinine adjusted for odds ratio (AOR). Results The study enrolled 126 adults with severe (n = 68) or mild/moderate (n = 58) COVID-19, with median age 50 [interquartile range (IQR 20–86)]; 57.1% males. The NLR value was significantly higher in severe cases [6.68 (IQR 3.03–12.21)] compared to the mild/moderate [3.23 (IQR 2.09–5.39)], with the NLR value markedly associated with disease severity (p<0.001). Mortality was higher in severe cases [13 (19.1%)] compared to mild/moderate cases [2 (3.4%)] (p = 0.007). The NLR value was significantly higher in non-survivors [15.17 (IQR 5.13–22.5)] compared to survivors [4.26 (IQR 2.40–7.90)] (p = 0.002). Serum creatinine was significantly elevated in severe cases [34 (50%)] compared with mild/moderate [11 (19%)] (p<0.001). Disease severity [AOR 6.58, 95%CI (1.29–33.56), p = 0.023] and NLR [AOR 1.07, 95%CI (1.02–1.12), p = 0.004)] might be associated with death. NLR had a sensitivity and specificity of 69.1% and 60.3% as predictor of disease severity (cut-off >4.08), and 86.7% and 55.9% as prognostic marker of mortality (cut-off >4.63). Conclusion In COVID-19, NLR is a biomarker with only modest accuracy for predicting disease severity and mortality. Still, patients with NLR >4.63 are more likely to die. Monitoring of this biomarker at the earliest stage of the disease may predict outcome. Additionally, high creatinine seems related to disease severity and mortality.
Demonstration of the Antitumor Activity of the iNKT Agonist ABX196, a Novel Enhancer of Cancer Immunotherapy, in Melanoma and Hepatocarcinoma Mouse Models

Abstract Immune checkpoint blockers (ICB) provide a promising approach to antitumor immunotherapy through blockade of immunosuppressive pathways. The synthetic glycolipid, ABX196, is a potent stimulator of invariant natural killer T cells (iNKT), a small subset of regulatory lymphocytes, which are powerful enhancers of immunity when activated. ABX196 was investigated alone and in combination with chemotherapy and ICBs in a melanoma B16F10 tumor cell-bearing and an orthotopic Hepa 1–6 hepatocarcinoma (HCC) cell-bearing C57BL/6 mice model. In the melanoma model, immune response evaluation included immunofluorescence staining and detection by flow cytometry to identify anti-CD45, anti-CD8, anti-CD4, anti-CD3, anti-CD19, anti-FoxP3, CD1d tetramer, and anti—programmed cell death protein 1 (PD-1) markers. Analysis by MRI, liver weight, and IHC staining to detect CD4, CD8, F4/80, PD-1, programmed death-ligand 1, Ki67, and FoxP3 markers were used to measure antitumor response in the HCC model. Combination treatment with ABX196 and anti–PD-1 resulted in significant synergistic antitumor effects, reflected by the increase of CD8+ cells in the tumor and an increased ratio of CD8+ effector cells to FoxP3+ regulatory T cells (Treg) in mice with melanomas. ABX196 monotherapy and combination therapy resulted in antitumor effects in the HCC model. No significant differences in survival were demonstrated between monotherapy and combination therapy due to high response levels with either treatment. A synergistic combination effect was apparent when IFNγ was measured in peripheral blood, indicating sustained activation of iNKT cells. In both models, the antitumor effects were associated with a generation of a more advantageous T-effector to Treg cell ratio within the tumor, which could lead to in the proliferation and accumulation of cells that would otherwise be anergized. Synopsis: Using melanoma and HCC tumor models in mice, this study demonstrates the potential of ABX196, alone and in combination with anti–PD-1 antibody, as a novel strategy to overcome the immunosuppressive microenvironment and to produce antitumor activity.
Childbirth experience in induced labor: A prospective study using a validated childbirth experience questionnaire (CEQ) with a focus on the first birth

Objective First birth and labor induction are risk factors for negative childbirth experiences. As labor inductions are increasing, research into this high-risk group’s childbirth experiences is important. We aimed to investigate whether nulliparity or factors related to labor induction, labor, and delivery explain the association. Methods This was a prospective study of 711 women undergoing labor induction at Helsinki University Hospital, Finland, between January 1, 2019, and January 31, 2020. The participants answered the Childbirth Experience Questionnaire (CEQ) after delivery (response rate 69.4%). The patient characteristics and delivery outcomes were collected from patient records. We analyzed the results for nulliparous and parous women. Results The mean CEQ scores were 2.9 (SD 0.5) for nulliparous women (n = 408) and 3.2 (SD 0.5) for parous women (n = 303), on a scale of 1–4; higher scores represent more positive experiences. However, 7.3% of the women had negative childbirth experiences (8.8% nulliparous; 5.3% parous, p = 0.08). Negative experiences were associated with a cesarean section (OR 6.7, 95% CI 1.8–9.3, p < 0.001) and a hemorrhage ≥ 1500 ml in vaginal delivery (OR 2.8, 95% CI 1.1–7.5, p = 0.03). In the separate CEQ domains analyses, nulliparity was associated with negative experiences in the “Own Capacity” domain (OR 1.6, 95% CI 1.0–2.4, p = 0.03). Cervical ripening, oxytocin use, and daytime delivery were associated with negative experiences in at least one domain, whereas epidural or spinal analgesia was regarded positively in two domains and negatively in one. Conclusions Nulliparous women undergoing labor induction risk negative childbirth experiences mainly due to labor and delivery-related factors, similar to parous women. Their perceptions of their capacity and preparedness for labor and delivery should be enhanced antenatally. An effective labor induction protocol promoting as high a rate of vaginal delivery as possible and preparedness to promptly respond to postpartum hemorrhage are key for avoiding negative childbirth experiences.
N2H+ and HC3N Observations of the Orion A Cloud

The ``integral-shaped filament'' of the Orion A giant molecular cloud was mapped in N2H+, and its northern end, the OMC-2/3 region was observed also in HC3N and CCS. The N2H+ distribution is similar to the dust continuum distribution, except for the central part of the Orion Nebula. The distribution of H13CO+ holds resemblance to that of dust continuum, but the N2H+ distribution looks more similar to dust continuum distribution. The N-bearing molecules, N2H+ and NH3 seem to be more intense in OMC-2, compared with the H13CO+ and CS distribution. We identified 34 cloud cores from N2H+ data. Over the Orion Nebula region, the N2H+ linewidth is large (1.1-2.1 km/s). In the OMC-2/3 region, it becomes moderate (0.5-1.3 km/s), and it is smaller (0.3-1.1 km/s) in the south of the Orion Nebula. On the other hand, the gas kinetic temperature of the quiescent cores observed in N2H+ is rather constant (~ 20 K) over the $\int$-shaped filament. We detected no CCS emission in the OMC-2/3 region. In general, N2H+ and HC3N distribution is quite similar in the OMC-2/3 region, but we observed displacement between N2H+ and HC3N over 2' scale in OMC-3, which has a chain of Class 0-I protostars (candidates).
Residual humoral immunity sustained over decades in a cohort of vaccinia-vaccinated individuals.

In 2019, Singapore experienced a case of imported Monkeypox. As with smallpox, disease can be prevented through vaccination, which was mandatory for Singaporean infants until 1981. However, the degree of residual immunity in older vaccinated Singaporeans remains unknown. Sera from individuals born from 1946-1984 were therefore tested and those born prior to 1981 were found to have higher anti-vaccinia IgG and neutralizing activity titres. This suggests that protective humoral immunity remains which could reduce disease severity in an orthopoxvirus outbreak. Correlation between IgG and neutralizing titres was observed indicating that serology could be used as a surrogate marker for immunity.
Kinematics of the Galactic disc from a LAMOST dwarf sample

Based on the LAMOST survey and Sloan Digital Sky Survey (SDSS), we use low-resolution spectra of 130,043 F/G-type dwarf stars to study the kinematics and metallicity properties of the Galactic disk. Our study shows that the stars with poorer metallicity and larger vertical distance from Galactic plane tend to have larger eccentricity and velocity dispersion. After separating the sample stars into likely thin-disk and thick-disk sub-sample, we find that there exits a negative gradient of rotation velocity $V_{\phi}$ with metallicity [Fe/H] for the likely thin-disk sub-sample, and the thick-disk sub-sample exhibit a larger positive gradient of rotation velocity with metallicity. By comparing with model prediction, we consider the radial migration of stars appears to have influenced on the thin-disk formation. In addition, our results shows that the observed thick-disk stellar orbital eccentricity distribution peaks at low eccentricity ($e \sim 0.2$) and extends to a high eccentricity ($e \sim 0.8$). We compare this result with four thick-disk formation simulated models, and it imply that our result is consistent with gas-rich merger model.
Novel NRF2‐activated cancer treatments utilizing synthetic lethality

The KEAP1‐NRF2 pathway regulates the main inducible cellular response to oxidative and electrophilic stresses. Activating mutations in the KEAP1‐NRF2 pathway occur commonly in human cancer, where they contribute to the formation of aggressive tumours that are associated with a poor prognosis for patients. An important clinical feature of these tumours is their defiance to all current anti‐cancer treatment regimens, highlighting the need for the development of new therapeutic strategies to target NRF2‐activated cancers. In this review, we discuss the mechanisms through which acquired NRF2 hyperactivation can result in resistance of tumours to immune checkpoint inhibitor therapies in addition to classical chemotherapeutics, and propose with examples that using a synthetic lethal strategy mediated by NRF2‐target gene‐dependent bioactivation of prodrugs represents a promising strategy to specifically enhance toxicity to heretofore untreatable NRF2‐hyperactivated human tumours.
Topological code Autotune

Many quantum systems are being investigated in the hope of building a large-scale quantum computer. All of these systems suffer from decoherence, resulting in errors during the execution of quantum gates. Quantum error correction enables reliable quantum computation given unreliable hardware. Unoptimized topological quantum error correction (TQEC), while still effective, performs very suboptimally, especially at low error rates. Hand optimizing the classical processing associated with a TQEC scheme for a specific system to achieve better error tolerance can be extremely laborious. We describe a tool Autotune capable of performing this optimization automatically, and give two highly distinct examples of its use and extreme outperformance of unoptimized TQEC. Autotune is designed to facilitate the precise study of real hardware running TQEC with every quantum gate having a realistic, physics-based error model.