Miracle-dz/UniFAR-FTUs huggingface dataset:
NSCLC: a target Population for a multivalent NY-ESO-1, CT7/MAGE-C1 and CT10/MAGE-C2 vaccine

1. Abstract Background: Lung cancer is a leading cause of cancer death in men and women worldwide. In past decade were to New chemotherapeutic agents and several targeted drugs have been introduced. But outcome remains poor with an overall five-year relative survival rate less than 20%. Therefore new treatment approaches are needed. Several studies have suggested that standard treatment in combination with immunotherapy could be more effective. Cancer testis (CT) antigens seem to represent promising immune targets and have been tested in multiple vaccine formulations. Purpose: The aim of this study was to define a non-small cell lung cancer (NSCLC) patient population for a multivalent NY-ESO-1, CT7/MAGE-C1-, and CT10/MAGE-C2 vaccine. Method: Two consecutively acquired cohorts of NSCLC specimens from chemotherapy naïve or treated patients were collected at the Surgical Pathology in Zurich over the course of 9 years. In a first cohort, consecutive surgically resected NSCLC patients, who have not received chemotherapy yet, were included. In a second, smaller cohort patients who had received chemotherapy were analyzed. Considered histologies were adenocarcinoma, squamous cell carcinoma, and adeno-squamous carcinoma of the lung. A patient database with clinical and pathological characteristics was setup from all collected specimen. Two tumor cores of each specimen were immunohistochemically stained for the CT antigens NY-ESO-1, CT7/MAGE-C1, and CT10/MAGE-C2. Expression frequency and co-expression of the CT antigens as well as the proliferation rate was analyzed. Further the expression of CT antigens was correlated with clinical and pathological characteristics and the CT antigen expression was compared between the chemotherapy naïve and treated patient tumor specimens. Results: The examined CT antigens were expressed in a coordinated manner. Overall CT10/MAGE-C2 was the most frequently expressed CT antigen. In a subgroup analysis squamous cell carcinomas were found to express NY-ESO-1 at a significantly higher rate
Genetic suppressors of C. elegans pha-4/FoxA identify the predicted AAA helicase ruvb-1/RuvB

FoxA transcription factors are critical regulators of gut development and function. FoxA proteins specify gut fate during early embryogenesis, drive gut differentiation and morphogenesis at later stages and impact gut function to mediate nutritional responses. The level of FoxA is critical for these roles, yet we know relatively little about regulators for this family of proteins. To address this issue, we conducted a genetic screen for mutants that suppress a partial loss of pha-4 , the sole FoxA factor of C. elegans . We identified 55 mutants using either chemical or insertional mutagenesis. 42 of these were informational suppressors that affected nonsense-mediated decay, while the remaining 13 were pha-4 suppressors. These 13 alleles defined at least 6 different loci. Based on mutational frequencies for C. elegans and the genetic dominance of four of the suppressors , we predict that many of the suppressors are either unusual loss-of-function mutations in negative regulators or rare gain-of-function mutations in positive regulators. We characterized one dominant suppressor molecularly and discovered the mutation alters a likely cis-regulatory region within pha-4 itself. A second suppressor defined a new locus, the predicted AAA+ helicase ruvb-1 . These results indicate that our screen successfully found cis or trans-acting regulators of pha-4 .
DDDT_A_303497 2129..2141

Department of Medical Sciences, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangdong Cardiovascular Institute, Guangzhou, 510080, People’s Republic of China; Department of Critical Care Medicine, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510080, Guangdong, People’s Republic of China; School of Biology and Biological Engineering, South China University of Technology, Guangzhou, Guangdong, 510080, People’s Republic of China; Department of Oncology, Maoming People’s Hospital, Maoming, 525000, Guangdong, People’s Republic of China; Department of Neurosurgery, Guangzhou First People’s Hospital, School of Medicine, South China University of Technology, Guangzhou, Guangdong, 510180, People’s Republic of China; Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, Guangdong, People’s Republic of China; Department of Intensive Care Unit, Guangdong 999 Brain Hospital, Guangzhou, 510510, Guangdong, People’s Republic of China; Department of Intensive Care Unit of Cardiovascular Surgery, Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Laboratory of South China Structural Heart Disease, Guangzhou, 510080, Guangdong, People’s Republic of China; The Second School of Clinical Medicine, Southern Medical University, Guangzhou, 510000, Guangdong, People’s Republic of China
Sub-Saharan Africa 1 is the dominant cryptic species of Bemisia tabaci (Gennadius) (Hemiptera: Aleyrodidae) associated with cassava in Madagascar

Сassava’s productivity in Madagascar is affected by pests and diseases, among which the whitefly Bemisia tabaci (Gennadius) transmitting cassava mosaic be­ gomoviruses (CMBs) is most important. The pre sent study sought to establish the abundance and diversity of B. tabaci cryptic species on cassava and other host plants in Madagascar. In addition, cassava mosaic disease (CMD) incidence and symptom severity were assessed. The identity and genetic diversity of B. ta baci samples collected on cassava and other plant species in Central High­ lands and Tsaratanana Massif in northwestern region were studied using the par tial mitochondrial cytochrome oxidase I (mtCOI) gene. The analyses of the mtCOI sequences revealed three B. tabaci cryptic species—Sub­Saharan Africa 1 (SSA1), Mediterranean (MED) and the Indian Ocean (IO)—in the sampled areas. SSA1 was the do mi nant cryptic species, with 100 % occurrence on cas­ sava crops. For the first time, we report the occurrence of MED in Madagascar. Both MED and IO, the in di genous species in the South West Indian Ocean is­ lands of Anajouan Mayotte, Grande Comore, Mauritius, Reunion, Seychelles and Mada gascar, occurred on non­cassava hosts. As opposed to previous reports, we re corded no B. tabaci Middle East Asia Minor 1 – MEAM1 cryptic spe cies (for merly also known as the B­biotype) on any of the sampled plants and lo ca­ tions. Generally, the abundance of adult whiteflies was low (<1 specimen per plant) on cassava in all the sampled locations, except in Analavory (3.93) and Am pitolova (3.00) in Central Highlands. Similarly, the whitefly abundance was low on the non­cas sava plant species, likely hosts for B. tabaci Io and meD. Cas sava mosaic di sease was observed in 100 % of the surveyed cassava fields. The disease symp toms were generally mild, with severities of 2.00–3.13 (ave­ rage, 2.62). Lo ca tions differed significantly (P<0.001, LSD=5.00) in CMD in­ ci dences. The CMD incidence ranged between 30–100 % (averaged ca 59 %). Our findings provide current knowledge of the economically important B. tabaci species, which is vital to the development of sustainable management practices for the vector and cassava viral diseases in Madagascar.
Prolonged Cortisol Reactivity to Stress and White Matter in Schizophrenia

Objective— While acute hypothalamic-pituitary-adrenal axis response to stress is often adaptive, prolonged responses may have detrimental effects. Many components of white matter structures are sensitive to prolonged cortisol exposure. We aimed to identify a behavioral laboratory assay for which cortisol response related to brain pathophysiology in schizophrenia. We hypothesized that an abnormally prolonged cortisol response to stress may be linked to abnormal white matter integrity in patients with schizophrenia. Methods— Acute and prolonged salivary cortisol response was measured outside the scanner at pre-test and then at 0, 20, and 40 minutes after a psychological stress task in patients with schizophrenia (n=45) and controls (n=53). Tract-averaged white matter was measured by 64-direction diffusion tensor imaging in a subset of patients (n=30) and controls (n=33). Results— Patients who did not tolerate and quit the psychological stress task had greater acute (t=2.52, p=0.016; t=3.51, p=0.001 at zero and 20 minutes) and prolonged (t=3.62, p=0.001 at 40 minutes) cortisol reactivity compared with patients who finished the task. Abnormally prolonged cortisol reactivity in patients was significantly associated with reduced white matter integrity (r= −0.468, p=0.009). Regardless of task completion status, We investigated examined We
THE INTERNATIONAL JOURNAL OF HUMANITIES & SOCIAL STUDIES Disciplinary Procedures and Justice for Accused Officers: A Case of the Administration Police Service in Nairobi City County, Kenya

as a critical value of a company’s leadership philosophy and practised through a code of well expounded regulations by the organization’s leadership, it may create a system-wide dedication which is important, special and appealing to the sight of workers and clients Cropanzano, Bowen and Gilliland (2007). Organizational justice denotes the workers conviction on workplace processes, interaction and outcomes to be impartial and correct, Baldwin (2006). Abstract: It had been observed that a number of Administration Police officers that had been subjected to disciplinary proceedings had appealed in court the outcomes of the disciplinary process citing procedural unfairness that resulted to unjust outcomes. The purpose of this study was to explore the nexus between disciplinary procedures and justice in the Administration Police Service. The study was conducted in Nairobi City County, Kenya and was anchored on theory of justice by John Rawls. A mixed research design of cross-sectional survey design and exploratory research design were employed on a target population of 679.The sample size was calculated using Yamane sampling formula generating a sample size of 251 officers that were requested to fill the questionnaires. This was followed by multi-stage sampling that included stratified random sampling at the sub county level to get the actual participants in the study for each stratum. Purposive sampling was used to get 8 key informants two groups of 6-8 police officers totaling to 14 police officers that had been subjected to disciplinary proceedings to participate in focus group discussion. The study established that majority of presiding officers were not independent in making ruling and are not experience in application of their discretionary power in orderly room proceedings. The study determined that there was need for change on disciplinary procedures in APS and recommended that presiding officers be trained and retrained on disciplinary process. The findings of the study indicated that there was divided opinion on whether or not the disciplinary procedures in the Administration police service required change in order to enhance justice to an accused police officer in ORP. Whereas majority of key informant preferred the disciplinary procedures to remain in their current state, majority of other respondents in FGD and response from questionnaires proposed change in disciplinary procedures.
Method for Automatic Resumption of Runtime Veriﬁcation Monitors

—In networked embedded systems created with parts from different suppliers, deviations from the expected communication behavior often cause integration problems. Therefore, runtime veriﬁcation monitors are used to detect if observed communication behavior fulﬁlls deﬁned correctness properties. However, in order to resume veriﬁcation if unspeciﬁed behavior is observed, the runtime monitor needs a deﬁnition of the resumption. Otherwise, further deviations may be overlooked. We present a method for extending state-based runtime monitors with resumption in an automated way. This enables continuous monitoring without interruption. The method may exploit diverse resumption algorithms. In an evaluation, we show how to ﬁnd the best suited resumption extension for a speciﬁc application scenario and compare the algorithms.
A COMPARATIVE EVALUATION OF INTRAVENOUS ESMOLOL, LIGNOCAINE AND LIGNOCAINE 10% SPRAY IN ATTENUATING CARDIOVASCULAR RESPONSE TO LARYNGOSCOPY AND INTUBATION.

Objectives: To observe the cardiovascular changes, to study the magnitude of changes in normotensive patients and to observe the effects in attenuating the cardiovascular responses to laryngoscopy and intubation comparing three drugs. Methods: The study was carried out on 120 adult patients of either sex, in the age group 20-60 years Patients were divided into 4 groups of 30 patients each. Depending upon the drugs employed to attenuate the cardiovascular responses during laryngoscopy and intubation, Patients were randomly allocated to either group. Group I - The patients of this group received only normal saline and served as control group. Group II – The patients of this group received i/v injection 2% lignocaine hydrochloride 1.5 mg/kg body weight 2 minute before intubation. Group III – The patients of this group received 10% lignocaine spray 1.5mg/kg body weight laryngeotracheal just before intubation. Group IV –The patients of this group received i/v Esmolol 1.5mg/kg body weight 2 minute before intubation. The observations were made at 1min. , 3 min., 5 min., and at 10 minutes interval. Results: The result obtained from our study with this drug found that both i/v esmolol and i/v lignocaine an effective in controlling both SBP and DBP but not by the lignocaine 10% spray. Conclusions: Esmolol were more effective than i/v lignocaine in attenuating the both SBP and DBP. While in PR only esmolol was found effectively significant and rest other not significant. Esmolol, at an intravenous bolus dose of 1.5mg/kg, "provided consistent and reliable protection against increases in both HR and BP accompanying laryngoscopy and intubation. "
Graphical Gaussian models with symmetries

This thesis is concerned with graphical Gaussian models with equality constraints on the concentration or partial correlation matrix introduced by Hojsgaard and Lauritzen (2008) as RCON and RCOR models. The models can be represented by vertex and edge coloured graphs G = (V,e), where parameters associated with equally coloured vertices or edges are restricted to being identical. In the first part of this thesis we study the problem of estimability of a non-zero model mean μ if the covariance structure Σ is restricted to satisfy the constraints of an RCON or RCOR model but is otherwise unknown. Exploiting results in Kruskal (1968), we obtain a characterisation of suitable linear spaces Ω such that if Σ is restricted as above, the maximum likelihood estimator μ(with circumflex) and the least squares estimator μ* of μ coincide for μ ∈ Ω, thus allowing μ and Σ to be estimated independently. For the special case of Ω being specified by equality relations among the entries of μ according to a partition M of the model variables V, our characterisation translates into a necessary and sufficient regularity condition on M and (V,e). In the second part we address model selection of RCON and RCOR models. Due to the large number of models, we study the structure of four model classes lying strictly within the sets of RCON and RCOR models, each of which is defined by desirable statistical properties corresponding to colouring regularity conditions. Two of these appear in Hojsgaard and Lauritzen (2008), while the other two arise from the regularity condition ensuring equality of estimators μ(with circumflex) = μ* we find in the first part. We show each of the colouring classes to form complete lattices, which qualifies the corresponding model spaces for an Edwards-Havranek model selection procedure (Edwards and Havranek, 1987). We develop a coresponding algorithm for one of the model classes and give an algorithm for a systematic search in accordance with the Edwards-Havranek principles for a second class. Both are applied to data sets previously analysed in the literature, with very encouraging performances.
Influence of Moral View and Other Variables on Purchase Intentions Concerning Fashion Counterfeits

The purpose of this research was to examine the extent of deontological (values) and teleological evaluation (considering consequences) used in arriving at an ethical judgment concerning intention to purchase a fashion counterfeit. In addition, the effect of psychographic (attitudes toward counterfeiting, risk taking, self-image, value consciousness, public self-consciousness, and materialism) and product attributes (perceived fashion content, physical appearance, and image) on intention to purchase a counterfeit product were investigated. Two alternatives and possible consequences as well as the scenario were given to the participants. The first alternative is persuading a friend not to buy a counterfeit and the second alternative is purchasing a counterfeit product with a friend. Participants ( n = 245) were undergraduate volunteers enrolled in courses at a Midwestern university. Data were analyzed using confirmatory factory analysis and structural equation modeling. The proposed structural models fit the data adequately in both alternatives, and all paths were significant. Participants followed the decision making steps outlined by Hunt and Vitell (1986) in both alternatives. Personal characteristics exerted no influence on behavioral intentions concerning counterfeits. Two product-related characteristics (i.e., physical appearance of a counterfeit and projected image of a counterfeit) had direct effects on the behavioral intentions. The conclusions of this research are helpful in improving our understanding of variables that influence consumers’ purchasing counterfeit luxury products.
R E S E A R C H A R T I C L E MICROBIAL COMMUNITIES AND WATER QUALITY OF SOME GROUNDWATER SYSTEMS IN EGYPT

: Groundwater in Egypt is of a vital importance and the contamination of drinking groundwater wells is a common problem in many rural areas . Forty-three different sites were selected from eight rural Governorates (Qena, Sohag, Kalubiya, Menofiya, Sharqiya, Gharbiya, Kafr El-Sheikh and Daqahliya) to carry out this study. Study of the effect of heavy metals; aluminum (Al), manganese (Mn), chromium (Cr), arsenic (As), cadmium (Cd) and lead (Pb) on the growth of fungi and bacteria indicated that fungi were strongly resistant to heavy metals and could survive high metal concentrations than bacteria. Penicillium spp. showed resistance to all tested heavy metals except Cd, while Aspergillus spp. and Geotrichum sp. showed resistance to all. On the other hand, most bacterial isolates were sensitive to Cd, Cr, Pb and As and showed some resistance to Al. Furthermore, Pseudomonas aeruginosa, Bacillus licheniforms, Kurthia gipsonii , and Escherichia coli were the most resistant isolates. Results showed that 96% of bacterial isolates were resistant to one or more of the tested antibiotics. None of the tested isolates showed resistance to ofloxacin. Also, about 58% of the total resistant isolates showed multiple antibiotic resistance (MAR), and Pseudomonas aeruginosa was the most resistant species. On the other hand, the calculated antibiotic resistance index (ARI) for the bacterial isolates collected from the groundwater at Gharbiya did not exceed the high risk level while that of Kafr El-Sheikh, Sohag, Kalubiya, Daqahliya, Menofiya and Qena considered as water of high risk pollution. Some interactions between fungal and bacterial communities were also studied. Results indicated that Chlorination of groundwater affected the count of total coliform and fecal coliform bacteria and about 70% and 90% of fungal and bacterial counts, respectively, were removed. The water quality index (WQI) for the selected areas was also studied. Finally, we recommended that the groundwater quality status of the rural areas must be studied carefully and the mycobiota of water should be considered when the microbiological safety and quality of drinking water are assessed.
Cohomology of unbranched Riemann domains over $q$-complete spaces

In this article, we show that if $\Pi: X\rightarrow Y$ is an unbranched Riemann domain over an $r$-complete complex space $Y$, then for any coherent analytic sheaf ${\mathcal{F}}$ on $X$ the cohomology group $H^{p}(X,{\mathcal{F}})$ vanishes for all $p\geq q+r-1. $ In particular, one gets a positive answer to a generalization of the local Stein problem and new vanishing theorems for the cohomology of locally $q$-complete open sets in $r$-complete spaces.
A Review of Economic Relationship among Self, Society and Nation: Parallels between Behavioral Economics and Economics based on the Ultron-Logotron Theory

A scientific, economic relationship among self, society and nation is still not clearly known in philosophy, sociology and economics because of lack of concrete human data that would enable us to substantiate it. Humanity experienced many conflicting economic and political systems. The author published an article, “The Science of Self, Mind and Body”. On the basis of the article, the two articles, “Economic Relationship among Self, Society and Nation” and “A Review of the Ultron-Logotron Theory: Consciousness and Quantum Physics” of ontological research were published. In this study, the Behavioral Economics of Richard Thaler was compared with the economics based on the ultron-logotron theory. The results of the study revealed remarkable parallels between both economics, and also a possibility of explanation of the behavioral economics by the ultron-logotron theory (ULT).
BIROn - Birkbeck Institutional Research Online and the lost the

Generations, and generational categories, offer a means of organising our understandings of age and age-related issues. Particularly within practitioner-orientated debates, differences between generations are highlighted as creating tensions which organisations must address. In contrast, we offer a critical interrogation of generations and unpack the implications of particular constructions. Specifically we examine the discursive construction of generational issues in UK online news about age at work, focusing on baby boomers and the lost generation. We highlight the discursive work involved in constructing each generation as entitled to work and how responsibility for employment issues is variously positioned. These inter-related concerns develop into a debate about consequences, as different versions of the