Miracle-dz/UniFAR-FTUs huggingface dataset:
Optimizing whole blood storage: hemostatic function of 35‐day stored product in CPD, CP2D, and CPDA‐1 anticoagulants

Transitioning from whole blood (WB) to components developed from efforts to maximize donor yield. Components are advantageous for specific derangements, but treating hemorrhage with components requires significantly more volume to provide similar effects to WB. Because storage lesion and waste remain problematic, this study examined hemostatic function of refrigerated WB stored for 35 days in anticoagulants citrate–phosphate‐dextrose‐adenosine (CPDA‐1), citrate–phosphate‐dextrose (CPD), or citrate–phosphate‐double dextrose (CP2D).
19-Substituted benzoquinone ansamycin heat shock protein-90 inhibitors: Biological activity and decreased off-target toxicity

The benzoquinone ansamycins (BQAs) are a valuable class of antitumor agents that serve as inhibitors of heat shock protein-90 (Hsp90). However, clinical use of BQAs has resulted in off-target toxicities including concerns of hepatotoxicity. Mechanisms underlying the toxicity of quinones include their ability to redox cycle and/or arylate cellular nucleophiles at the unsubstituted 19-position of the molecule. We have therefore designed 19-substituted BQAs to prevent glutathione conjugation and non-specific interactions with protein thiols to minimize off-target effects and reduce hepatotoxicity. 19-Phenyl and 19-methyl substituted versions of GA and its derivatives, 17-AAG and 17-DMAG, did not react with glutathione, while marked reactivity was observed using parent BQAs. Importantly, while 17-DMAG induced cell death in primary and cultured mouse hepatocytes, 19-phenyl and 19-methyl DMAG showed reduced toxicity, validating the overall approach. Furthermore, our data suggest that arylation reactions rather than redox cycling are a major mechanism contributing to BQA hepatotoxicity. 19-phenyl BQAs inhibited purified Hsp90 in an NAD(P)H oxidoreductase 1 (NQO1)-dependent manner, demonstrating increased efficacy of the hydroquinone ansamycin relative to its parent quinone. Molecular modeling supported increased stability of the hydroquinone form of 19-phenyl-DMAG in the active site of human Hsp90. In human breast cancer cells, 19-phenyl BQAs induced growth inhibition also dependent upon metabolism via NQO1 with decreased expression of client proteins and compensatory induction of Hsp70. These data demonstrate that 19-substituted BQAs are unreactive with thiols, display reduced hepatotoxicity, and retain Hsp90 and growth inhibitory activity in human breast cancer cells although with diminished potency relative to parent BQAs. a major mechanism of hepatotoxicity. Using three separate approaches: a) purified NQO1, b) human breast cancer cells isogenic for NQO1, and c) molecular modeling, we also demonstrated that 19BQAs inhibit Hsp90 in an NQO1 dependent manner, emphasizing the importance of the hydroquinone ansamycin. Finally, our work shows that the 19BQAs are effective Hsp90 inhibitors and induce growth inhibitory effects in human breast cancer cells. When combined with diminished off-target toxicity, these novel 19BQA compounds may have a greater therapeutic window than their parent quinones.
Arabic Image Captioning using Pre-training of Deep Bidirectional Transformers

Image captioning is the process of automati-001 cally generating a textual description of an im-002 age. It has a wide range of applications, such as 003 effective image search, auto archiving and even 004 helping visually impaired people to see. En-005 glish image captioning has seen a lot of devel-006 opment lately, while Arabic image captioning 007 is lagging behind. In this paper, we developed 008 and evaluated several Arabic image caption-009 ing models with well-established metrics on a 010 public image captioning benchmark. We initial-011 ized all models with transformers pre-trained 012 on different Arabic corpora. After initializa-013 tion, we fine-tuned them with image-caption 014 pairs using a learning method called OSCAR. 015 OSCAR uses object tags detected in images as 016 anchor points to significantly ease the learning 017 of image-text semantic alignments. In relation 018 to the image captioning benchmark, our best 019 performing model scored 0.39, 0.25, 0.15 and 020 0.092 with BLEU-1,2,3,4 respectively, an im-021 provement over previously published scores 022 of 0.33, 0.19, 0.11 and 0.057. Beside addi-023 tional evaluation metrics, we complemented 024 our scores with human evaluation on a sample 025 of our output. Our experiments showed that 026 training image captioning models with Arabic 027 captions and English object tags is a working 028 approach, but that a pure Arabic dataset, with 029 Arabic object tags, would be preferable. 030
Health‐related quality of life change in patients treated at a multidisciplinary pain clinic

Multidisciplinary pain management (MPM) is a generally accepted method for treating chronic pain, but heterogeneous outcome measures provide only limited conclusions concerning its effectiveness. Therefore, further studies on the effectiveness of MPM are needed to identify subgroups of patients who benefit, or do not benefit, from these interventions. Our aim was to analyse health‐related quality of life (HRQoL) changes after MPM and to identify factors associated with treatment outcomes.
Investment Efforts Under Complementary Sourcing: The Role of Market Risk and Endogenous Pricing

Problem definition: Complementary sourcing, with which a product depends on both a supplier’s and a manufacturer’s engineering and production efforts, is ubiquitous in modern supply chains. A unique feature of complementary sourcing is that efforts by one party enhance the marginal value of the other party’s efforts. Whereas this positive spillover effect can benefit both parties, it is well-established in the literature that it paradoxically induces a first-mover disadvantage; neither party is willing to exert efforts ex ante, resulting in significant lost opportunities for improving sourcing performance. The question we consider in this paper is whether the first-mover disadvantage is a valid concern in more realistic sourcing environments in which the market is risky and price is endogenous. Methodology/results: We analyze a sequential-investment model and investigate how market risk and endogenous pricing affect the first-mover disadvantage. In the presence of market risk, the first mover may face greater market uncertainty than the second mover and, thus, is at an apparent disadvantage. Surprisingly, we find the introduction of market risk can favor the first mover. In effect, the presence of market risk weakens the second mover’s ability to free ride on the first mover’s investment, which increases the leverage of the first mover. This finding persists with exogenous pricing even if the first mover has weak power. Managerial implications: Our results suggest that the first-mover disadvantage identified in the extant literature ignores the operational aspect of practical sourcing environments, and sourcing managers should recognize that advance effort investment is often beneficial in more realistic complementary sourcing environments.
Effects of dietary acidification and acid source on fish growth and feed efficiency (Review)

The human population has increased considerably worldwide, including in the Philippines. Aquaculture is one of the main food sectors that provides a cheap source of protein in the Philippines. Changes in diet composition in aquacul‐ ture have brought about concerns regarding certain negative effects at the gastrointestinal levels. The replacement of fish meal with a plant protein source in a considerable proportion in the diet of the majority of cultured fish species has led to proliferative and inflammatory responses in the intestines of various (functionally) monogastric animals. In aquacul‐ ture feed, the dietary supplementation of organic acids and their salts as growth promoters has been established. The use of acidifiers in aquafeed requires a different approach due to diversified feeding habits and the wide variation in the digestive system structure and physiological function. Dietary organic acids can increase pancreatic enzyme production, decrease stomach pH levels, inhibit pathogens, provide energy, improve mineral utilization and improve nutrient digestibility, all of which improve fish development performance. Acidifiers are currently widely used in animal feed, including aquafeed, and several manufacturers have created next‐generation acidifiers with additional benefits. The present review article discusses the acidifiers, their mechanisms of action, growth, feed efficiency, immunity and future research opportunities. The fish growth rate and feed utilization efficiency are also reviewed as regards dietary acid sources, such as acetic acid, citric acid, hydrochloric acid and control‐no acid. In addition, the attractability of the diets for the fish at different pH levels and dietary acid sources was determined. The survival rates of cultured fishes were determined based on the various dietary acids used. Any acids at an optimum pH level, e.g., pH 4.6 in the diet of tilapia fry, which increase attractability, growth and feed efficiency, warrant further attention.
Mechanisms involved in alleviation of inflammation by Bifidobacterium breve soluble factors

Objectives: Soluble factors released by Bifidobacterium breve C50 (Bb) alleviate the secretion of pro-inflammatory cytokines by immune cells, but their effect on intestinal epithelium remains elusive. To decipher the mechanisms accounting for the cross-talk between bacteria/soluble factors and intestinal epithelium, we measured the capacity of the bacteria, its conditioned medium (Bb-CM) and other Gram(+) commensal bacteria to dampen inflammatory chemokine secretion. Methods: TNFa-induced chemokine (CXCL8) secretion and alteration of NF-kB and AP-1 signalling pathways by Bb were studied by EMSA, confocal microscopy and western blotting. Anti-inflammatory capacity was also tested in vivo in a model of TNBS-induced colitis in mice. Results: Bb and Bb-CM, but not other commensal bacteria, induced a time and dose-dependent inhibition of CXCL8 secretion by epithelial cells driven by both AP-1 and NF-kB transcription pathways and implying decreased phosphorylation of p38-MAPK and IkB-a molecules. In TNBS-induced colitis in mice, Bb-CM decreased the colitis score and inflammatory cytokine expression, an effect reproduced by dendritic cell conditioning with Bb-CM. Conclusions: Bb and secreted soluble factors contribute positively to intestinal homeostasis by attenuating chemokine production. The results indicate that Bb down regulate inflammation at the epithelial level by inhibiting phosphorylations involved in inflammatory processes and by protective conditioning of dendritic cells. Citation: Heuvelin E, Lebreton C, Grangette C, Pot B, Cerf-Bensussan N, et al. (2009) Mechanisms Involved in Alleviation of Intestinal Inflammation by Bifidobacterium Breve Soluble Factors. PLoS ONE 4(4): e5184. doi:10.1371/journal.pone. 0005184 Editor: Stefan Bereswill, Charité-Universitätsmedizin Berlin, Germany Received February 12, 2009; Accepted March 11, 2009; Published April 17, 2009 Copyright: 2009 Heuvelin et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Funding: This work was funded by INSERM, the Princess Grace Foundation, Bledina-SA and the Fondation pour la Recherche Medicale. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Competing Interests: The authors have declared that no competing interests exist. * E-mail: martine.heyman@inserm.fr
Implant treatment in immunosuppressed renal transplant patients: A prospective case-controlled study.

OBJECTIVES The aim of this clinical study was to evaluate long-term outcomes of implant therapy in a cohort of immunosuppressed renal transplant patients compared with a matched control group. MATERIAL AND METHODS Pharmacologically immunosuppressed renal transplant patients received dental implant treatment between 2001 and 2011. Periodontal, clinical and radiographic parameters were prospectively measured with a mean follow-up of 116.8 months (range from 84 to 192 months). A matched controlled non-transplant sample receiving similar implant treatment in the same time was included as a control group. RESULTS Implant survival rate was over 98% in both test and control groups (100% and 98.84%, respectively). Peri-implant mucositis was diagnosed in 46.80% of the implants in the study group and in 48.80% in the control group. Peri-implantitis occurred in 5.10% of the implants in the study group and in 8.10% of the controls. Wound healing and post-operative pain were similar in both groups. CONCLUSIONS Despite the limitations of this study, pharmacological immunosuppression in renal transplant patients did not affect implant outcomes. Renal transplant patients should be carefully controlled periodically after implant treatment. CLINICAL IMPLICATIONS The results from this investigation justify the use of dental implants for the dentalrehabilitation of immunosuppressed patients after renal transplantation provided they follow the necessarylong-term monitoring and regular maintenance of their oral and systemic health.
Human primary fibroblasts perform similarly to MSCs in assays used to evaluate MSC safety and potency

Cellular therapeutic agents may benefit trauma patients by modulating the immune response to injury, and by reducing inflammation and vascular leakage. Administration of allogeneic mesenchymal stromal cells (MSCs) shows some benefit in preclinical and clinical trials, but less testing has been performed with other cell types. Human primary fibroblasts (FBs) were compared to MSCs in assays designed to evaluate MSCs to determine if these assays actually evaluate properties unique to MSCs or whether related cell types perform similarly.
Effect of Temperature on Rheological Behavior of Liquid Milk and Its Impact to Adequacy of Thermal Process

Temperature is one of the factors affecting fluid flow characteristics and the thermal adequacy in milk sterilization in an aseptic system. This research is aimed to study density and rheology of milk at temperature of 20-80 0C and its effect to Reynold number and thermal sterility. Four different kinds of commercial milk were used. The density and rheological properties were measured by using densitometer a Brookfield Viscometer DV II, respectively. The results showed that the milks were Newtonian. Temperature affected the density and viscosity of the liquid milk and consequently affected the Reynolds number. Increased temperatures lead to decreased density and decreased viscosity which could be well described using an Arrhenius model. Combined effect of increased temperature on decreased density and viscosity resulted in increased Reynolds numbers. This indicated that Reynolds number is more affected by the value of viscosity rather than density, as temperature increased. Under a full-scale production set up in one of the milk factories, the four kinds of liquid milk exhibited turbulent fluid flow properties (Reynolds number more than 4000). Therefore, decreased viscosity and density of milk at elevated temperature did not adversely affect adequacy of aseptic thermal process at a constant flow rate.
Changes in donor antibody titer levels over time in a military group O low‐titer whole blood program

The ability to rapidly administer whole blood (WB) at the point of injury is an important intervention to save lives. This can be accomplished using low titer group O WB donors. Titers of immunoglobulin M anti‐A and anti‐B might change over time. This study describes titer testing in a large series of donors.
SPANISH ADAPTATION OF THE CTAI-2D. TOOL FOR ASSESSING THE TRAIT ANXIETY IN ATHLETES ADAPTACIÓN ESPAÑOLA DEL CTAI-2D. HERRAMIENTA PARA EVALUAR LA ANSIEDAD

Trait-Anxiety is a dispositional and stable measure whose evaluation is relevant in the sporting context as the way in which athlete's interpret feelings of anxiety is relevant to competitive performance. The purpose of the present study was to Rev.int.med.cienc. act. fís. deporte vol. 22 número 85 ISSN: 1577-0354 108 adapt the Competitive Trait Anxiety Inventory (CTAI-2D) into Spanish through a sample of 421 athletes (66.3% men and 33.7% women) aged between 18 and 46 years (mean = 21.16). Firstly, the CTAI-2D was translated. This was then followed by exploratory factor analysis (EFA) and examination of convergent validity. Finally, confirmatory factor analysis (CFA) was performed. EFA outcomes showed an explained variance of 52.95% for the intensity dimension and 55.55% for valence/direction, whilst CFA produced satisfactory fit indices. The CTAI-2D is a valid and reliable instrument for evaluating trait anxiety. It describes athlete's perceptions of anxiety intensity and whether anxiety is interpreted as an obstacle or facilitator.
Voice Based Email System for People with Visual Impairment

------------------------------------------------------------------------------------------------------------------------------------------------- ABSTRACT: One of the most essential privileges for daily life is access to the internet. Everyone uses the internet for facts and information. Communication has gotten much easier in today's society as a result of the integration of communication technologies with the internet. Visually impaired persons, on the other hand, find it extremely difficult to use this technology because it requires visual perception. Despite the fact that many new advancements have been implemented to assist them in using computers more effectively, no naive user who is visually challenged can use this technology as effectively as a normal naive user because, unlike normal users, they require some practice in using the available technologies. This study discusses the structural design of a voice-mail system that may be utilized by a blind person to readily retrieve E-mails. This strategy allows them to communicate easily and generates a lot of stronger and independent workers. The system will not allow the user to utilise the keyboard or keypad, instead relying solely on clicks, swipes, and motions, as well as speech to text conversion. The involvement of research is assisting blind people in sending and receiving voice-based mail messages in their native language via a mobile phone. This framework will be beneficial to people who have other limitations in addition to being visually impaired.
HILBERT’S TENTH PROBLEM AND MAZUR’S CONJECTURE FOR LARGE SUBRINGS OF Q

Hilbert’s Tenth Problem, in modern terms, was to find an algorithm (Turing machine) to decide, given a polynomial equation f(x1, . . . , xn) = 0 with coefficients in Z, whether it has a solution with x1, . , xn ∈ Z. Y. Matijasevič [Mat70], building on earlier work of M. Davis, H. Putnam, and J. Robinson [DPR61], showed that no such algorithm exists. If one replaces Z in both places by a different commutative ring R (let us assume its elements can be and have been encoded for input into a Turing machine), one obtains a different question, called Hilbert’s Tenth Problem over R, whose answer depends on R. These problems are discussed in detail in [DLPVG00]. In particular, the answer for R = Q is unknown. Hilbert’s Tenth Problem over Q is equivalent to the general problem of deciding whether a variety over Q has a rational point. One approach to proving that Hilbert’s Tenth Problem over Q has a negative answer would be to deduce this from Matijasevič’s theorem for Z, by showing that Z is diophantine over Q in the following sense: Definition 1.1. Let R be a ring, and let A ⊆ R. Then A is diophantine over R if and only if there exists a polynomial f in m+ n variables with coefficients in R such that A = { a ∈ R | ∃x ∈ R such that f(a, x) = 0 }.
Determinantsof Nationalization in the Oil Sector: A Theory and Evidence from Panel Data

In this article, we study nationalizations in the oil industry around the world during 1960–2006. We show, both theoretically and empirically, that governments are more likely to nationalize when oil prices are high and when political institutions are weak. We consider a simple dynamic model of the interaction between a government and a foreign-owned oil company. Even though nationalization is inefficient, it does occur in equilibrium when oil prices are high. The model’s predictions are consistent with the analysis of panel data on nationalizations in the oil industry around the world since 1960. Nationalization is more likely to happen when oil prices are high and the quality of institutions is low, even controlling for country fixed effects. (JEL D23, L33, L71, P48)
HCF-Net: Hybrid Coarse-to-Fine Network for Forgery Reconstruction

Due to the ubiquity of photo editing software, it is convenient and prevalent to create fake images which may cause terrible misunderstandings. To address this issue, we introduce forgery reconstruction, a novel image reconstruction that automati-callyreconstructsaforgedimageintoitsoriginalappearance. Toachievethis, wepresentanewtwo-phasesystem, including a forgery localization phase and a reconstruction phase, where we first localize forged regions and then inpaint the natural texture. The proposed approach, called HCF-Net, is a hybrid two coarse-to-fine networks. Unlike the existing solutions of image reconstruction that relies on the prior knowledge of the areas to be recovered, our proposed system is free from the mask information. To guide the reconstruction, we propose a new strategy for extracting noise features in the forgery localization phase, which leverages the relationships among the image channels and localizes the tampered regions more precisely. For better performance, we equip a dual attention module in the reconstruction phase. Our automatic system is applicable to localize the tampered areas and reconstruct the missing part in a single pass. The extensive experiments demonstrate that our system achieves state-of-the-art performance in forgery localization and generates higher-quality and more flexible results than traditional inpainting methods.
NBER WORKING PAPER SERIES LESSONS FROM DENMARK ABOUT INEQUALITY AND SOCIAL MOBILITY

Many American policy analysts point to Denmark as a model welfare state with low levels of income inequality and high levels of income mobility across generations. It has in place many social policies now advocated for adoption in the U.S. Despite generous Danish social policies, family influence on important child outcomes in Denmark is about as strong as it is in the United States. More advantaged families are better able to access, utilize, and influence universally available programs. Purposive sorting by levels of family advantage create neighborhood effects. Powerful forces not easily mitigated by Danish-style welfare state programs operate in both countries. James J. Heckman Center for the Economics of Human Development University of Chicago 1126 East 59th Street Chicago, IL 60637 and IZA and also NBER jjh@uchicago.edu Rasmus Landersø Rockwool Foundation Research Unit Ny Kongensgade 6 Copenhagen 1472 Danmark rl@rff.dk A data appendix is available at http://www.nber. org/data-appendix/w28543
Impacts of agroforestry on agricultural productivity, ecosystem services, and human well-being in terrace ecosystem of Bangladesh

How to cite this article: Islam MM, Khan MH, Nipa S, Islam MA, Eivy FZ, Hossain MS, Hasan MM, Alam MJ and Khan MMH (2021). Impacts of agroforestry on agricultural productivity, ecosystem services, and human well-being in terrace ecosystem of Bangladesh. International Journal of Natural and Social Sciences, 8(4): 20-31. DOI: 10.5281/zenodo.6349668 Impacts of agroforestry on agricultural productivity, ecosystem services, and human well-being in terrace ecosystem of Bangladesh