Miracle-dz/UniFAR-FTUs huggingface dataset:
The Potential Preventive and Therapeutic Roles of NSAIDs in Prostate Cancer

Simple Summary Prostate cancer is a serious health problem for men around the world, and it is often caused by inflammation in the prostate gland. The authors of this article explore how a group of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs) can help prevent and treat this disease by reducing inflammation and interfering with the growth and survival of cancer cells. We describe the various mechanisms by which NSAIDs can affect prostate cancer, such as triggering cell death, halting cell division, and cutting off blood supply. We also discuss the evidence from previous studies that support the use of NSAIDs as anti-cancer agents, either alone or in combination with other treatments. NSAIDs have a lot of promise as potential drugs for prostate cancer, but more research to understand their optimal dosage, timing, and safety is needed. Abstract Prostate cancer (PC) is the second most common type of cancer and the leading cause of death among men worldwide. Preventing the progression of cancer after treatments such as radical prostatectomy, radiation therapy, and hormone therapy is a major concern faced by prostate cancer patients. Inflammation, which can be caused by various factors such as infections, the microbiome, obesity and a high-fat diet, is considered to be the main cause of PC. Inflammatory cells are believed to play a crucial role in tumor progression. Therefore, nonsteroidal anti-inflammatory drugs along with their effects on the treatment of inflammation-related diseases, can prevent cancer and its progression by suppressing various inflammatory pathways. Recent evidence shows that nonsteroidal anti-inflammatory drugs are effective in the prevention and treatment of prostate cancer. In this review, we discuss the different pathways through which these drugs exert their potential preventive and therapeutic effects on prostate cancer.
Sea-Surface Temperature Record of ODP Site 1202B, the Southern Okinawa Trough

sea-surface temperature (SST) record of the last 28 kyr has been obtained for ODP Site 1202B (24°48.24'N, 122°30'E; water depth 1274 m), drilled offshore of NE Taiwan in the southern part of the Okinawa Trough. This millennial-scale record reveals a glacial-interglacial SST dif- ference of 5°C, larger than SST changes at similar latitude of the open Pa- cific Ocean, but is similar in amplitude with SST changes of the western Pacific's marginal seas, such as the northern South China Sea (SCS). Com- parison with a planktonic oxygen isotope record from the same site reveals that the last deglaciation warming was synchronous with ice volume changes, but lagged the warming in Greenland's ice core record and in the monsoon record from the Hulu Cave of Eastern China. The enhanced glacial cooling for this site was likely caused by several factors, including the variability of the Kuroshio, sea level variations, and coastline shift.
Analysis of physical and chemical characteristics of soil in coffee plantations in the Mount Puntang Social Forestry Area, West Java

Characteristics of soil physics, chemistry, and altitude are important aspects to assess the quality and level of soil fertility. Field studies and laboratory analysis have been carried out to determine some of the physical and chemical characteristics of the soil at an altitude of 1200 m 1300 m 1500 m above sea level. The research aims to analyze the physical and chemical properties of the soil at various altitudes in the coffee plantation social forestry area. The research was conducted in the highlands of Mount Puntang, West Java Province, using survey methods, field observations, and laboratory analysis. Soil samples were taken randomly and then analyzed for soil water content, texture, pH, C-Organic, Nitrogen, C/N ratio, P2O5, and K2O at the Cimanggu Soil Research Institute Laboratory, Bogor. The results showed that the highest available soil water was found at an altitude of 1300 m asl, namely, 15.83% at a depth of 30 cm, with a dusty loam texture. While pH (4.50 - 6.00), C-organic (1.99 - 4.32 %), N-total, (0.18 - 0.32 %) C/N-ratio (11 - 14 % ), P2O5 (8 -13 ppm) and K2O (461 – 579 ppm). Keywords: coffee plantation, physical properties, chemical properties, arabica Puntang, Puntang mountain
The youth-caregiver relationship quality in residential youth care: Professionals’ perceptions and experiences

This study aimed to explore the perceptions and experiences of professionals working in residential care (RC) settings (i.e., caregivers and directors) about youth-caregiver relationship quality (YCRQ). Method: A qualitative study was developed in Portugal including 15 caregivers (73.3% women, 23–50 years) and 15 directors (73.3% women, 34–45 years) working in 18 generalist RC units. Data were collected through six focus groups using a semi-structured interview script. Data were analyzed following a content analysis approach using NVIVO 12 software. Results: Our findings revealed that the concept of YCRQ in RC was mainly described in terms of good qualities, and the organizational determinants of YCRQ relationships were most mentioned both by caregivers and directors (i.e., organizational social context, intervention models and strategies). Individual characteristics of youth and staff were less described as determinants of YCRQ. These findings provide important insights for practice. Conclusions: efforts should be made to design interventions in RC that aim to improve its organizational social climate so as to provide caregivers with the necessary support and resources that enable them to enhance positive YCRQ.
Thermohaline circulation in the Arctic Mediterranean Seas

The renewal of the deep North Atlantic by the various overflows of the Greenland-Scotland ridges is only one manifestation of the convective and mixing processes which occur in the various basins and shelf areas to the north: the Arctic Ocean and the Greenland, Iceland, and Norwegian seas, collectively called the Arctic Mediterranean. The traditional site of deep ventilation for these basins is the Greenland Sea, but a growing body of evidence also points to the Arctic Ocean as a major source of deep water. This deep water is relatively warm and saline, and it appears to be a mixture of dense, brine-enriched shelf water with intermediate strata in the Arctic Ocean. The deep water exits the Arctic Ocean along the Greenland slope to mix with the Greenland Sea deep water. Conversely, very cold low-salinity deep water from the Greenland Sea enters the Arctic Ocean west of Spitsbergen. Within the Arctic Ocean, the Lomonosov Ridge excludes the Greenland Sea deep water from the Canadian Basin, leaving the latter warm, saline, and rich in silica. In general, the entire deep-water sphere of the Arctic Mediterranean is constrained by the Greenland-Scotland ridges to circulate internally. Therefore it is certain of the intermediate waters formed in the Greenland and Iceland seas which ventilate the North Atlantic. These waters have a very short residence time in their formation areas and are therefore able to rapidly transmit surface-induced signals into the deep North Atlantic.
Prevalence and Mortality Rates of Acute Kidney Injury among Critically Ill Patients: A Retrospective Study

Acute kidney injury (AKI) poses a significant challenge in critically ill patients. To determine the prevalence, risk factors, and mortality rate of AKI among nonsurgical critically ill patients in Jordan University Hospital, we conducted a retrospective study using a consecutive sampling method, including 457 nonsurgical critically ill patients admitted to the medical intensive care unit (MICU) from January to June 2021. The mean age was 63.8 ± 18 years, with 196 (42.8%) developing AKI during their stay in the MICU. Among AKI nonsurgical patients, pulmonary diseases (n = 52; 34.5%) emerged as the primary cause for admission, exhibiting the highest prevalence, followed by sepsis (n = 40; 20.4%). Furthermore, we found that older age (adjusted OR (AOR): 1.04; 95% confidence interval (CI): 1.04–1.06; p = 0.003), preadmission use of diuretics (AOR: 2.12; 95% CI: 1.06–4.25; p = 0.03), use of ventilators (2.19; 95% CI: 1.12–2.29; p = 0.02), and vasopressor use during MICU stay (AOR: 4.25; 95% CI: 2.1308.47; p = 0.001) were observed to have higher mortality rates. Prior utilization of statins before admission exhibited a significant association with reduced mortality rate (AOR: 0.42; 95% CI: 0.2–0.85; p = 0.02). Finally, AKI was associated with a higher mortality rate during MICU stay (AOR: 2.44; 95% CI: 1.07–5.56; p = 0.03). The prevalence of AKI among nonsurgical patients during MICU stay is higher than what has been reported previously in the literature, which highlights the nuanced importance of identifying more factors contributing to AKI in developing countries, and hence providing preventive measures and adhering to global strategies are recommended.
Solving Fractional Gas Dynamics Equation Using Müntz-Legendre Polynomials

To solve the fractional gas dynamic equation, this paper presents an effective algorithm using the collocation method and Müntz-Legendre (M-L) polynomials. The approach chooses a solution of a finite-dimensional space that satisfies the desired equation at a set of collocation points. The collocation points in this study are selected to be uniformly spaced meshes or the roots of shifted Legendre and Chebyshev polynomials. Müntz-Legendre polynomials have the interesting property that their fractional derivative is also a Müntz-Legendre polynomial. This property ensures that these bases do not face the problems associated with using the classical orthogonal polynomials when solving fractional equations using the collocation method. The numerical simulations illustrate the method’s effectiveness and accuracy.
Distributed Predefined-Time Algorithm for System of Linear Equations Over Directed Networks

In this brief, we propose a predefined-time algorithm based on multi-agent networks for solving linear equations of the form <inline-formula> <tex-math notation="LaTeX">$Ax = b$ </tex-math></inline-formula>, where the predefined-time can be predesigned by the user and each agent only knows partial rows of the augmented matrix <inline-formula> <tex-math notation="LaTeX">$(A\; b)$ </tex-math></inline-formula>. By reformulating the system of linear equations as an unconstrained optimization problem and applying the time-base generator technology to optimization approaches, we provide a gradient-based predefined-time algorithm over weight-balanced directed graphs, which can converge to a solution at a given time. Finally, this theoretical results are illustrated by a numerical examples.
Exposure dating outwash gravels to determine the age of the greatest Patagonian glaciations

The relict moraines in Argentine Patagonia archive major expansions of the Patagonian Ice Sheet throughout the Quaternary, and are one of the few terrestrial climate proxies in the middle latitudes of the Southern Hemisphere that extends beyond the last glacial cycle. Determining their individual ages has proved challenging but has important implications for our understanding of terrestrial climate change in southern South America over the duration of the Quaternary. Here, for the first time, we demonstrate that sediment on outwash terraces can be directly dated to determine the timing of early–middle Quaternary glacial advances in southern South America. Cosmogenic 10 Be and 26 Al surface exposure ages were obtained from outwash gravels associated with two of the oldest glacial sequences in the Lago Pueyrredon valley (47.5°S), Argentina. The outermost Gorra de Poivre glacial sequence marks the greatest extent of the Patagonian Ice Sheet. A cobble from this surface gives 10 Be and 26 Al surface exposure ages of ca. 1.2 Ma, consistent with bracketing 40 Ar/ 39 Ar age constraints obtained elsewhere in Patagonia. This is the first time early Pleistocene glacial surfaces have been directly dated in Patagonia. Cobbles on a younger Canadon de Caracoles outwash terrace give exposure ages of ca. 600 ka, while 4 of 5 boulders on an associated moraine give exposure ages that are significantly younger. If the demonstrated stability of outwash terraces in the valley is common throughout the region, it will be possible to extend Patagonian glacial chronologies as far back as the early Pleistocene.
A Case of Paraneoplastic Neurological Syndrome Leading to the Diagnosis of Large Cell Neuroendocrine Carcinoma From Opsoclonus-Myoclonus Syndrome

Opsoclonus-myoclonus syndrome (OMS) is a rare neurological disorder characterized by myoclonus, ataxia, and tremors. It can be classified as neoplastic or idiopathic, with small cell lung cancer being commonly associated. Herein, we present a rare case of refractory paraneoplastic neurological syndrome (PNS) caused by large cell neuroendocrine carcinoma (LCNEC), a rare form of non-small cell lung cancer (NSCLC). A 60-year-old otherwise healthy man presented with acute-onset dysarthria, gait instability, and numbness on the right side of his body. According to the clinical symptoms and neurological examination, we initially suspected cerebellar infarction; however, brain imaging revealed no abnormal findings. After a few days, the patient developed worsening horizontal nystagmus, irregular ocular rhythms, and generalized involuntary movements, indicative of OMS. A systemic evaluation revealed a solitary nodule in the lower lobe of the right lung, leading to a clinical diagnosis of PNS. The patient underwent segmentectomy to treat an early-stage LCNEC nodule after one month from onset. Despite all therapeutic interventions, OMS was refractory, and after consulting with the person himself and the family, palliative care was selected. However, the patient showed a clinical response belatedly five months after surgery. This case highlights the importance of considering PNS, and that it may be associated with a rare malignancy when cerebellar symptoms are observed, and the challenges in managing refractory PNS associated with rare forms of NSCLC.
How does risk aversion shape investors’ intentions? Evidence from the Indian corporate bond market

Risk aversion plays a crucial role in understanding how individuals make financial decisions and allocate their resources. This study analyzes the influence of risk aversion on behavioral intentions and explores the mediating role of attitudes, subjective norms, and perceived behavioral control. Additionally, it investigates the moderating effect of gender and financial literacy on behavioral intentions of investors. A sample of 400 people was collected from Indian retail investors by administering a structured questionnaire through stock brokering firms, and data were analyzed using Partial least squares – Structural equation modelling in the Smart PLS 3.3. 9 software. The research found that risk aversion, attitude, subjective norms, and perceived behavioral control significantly impact an investor’s intention. Among all the antecedents of behavioral intentions, perceived behavioral control (β 0.481*) was found as a significant predictor of the intention compared to attitude (β 0.154*), subjective norms (β 0.224*) and risk aversion (β 0.082*) factors. Further, mediation analysis found that attitude, subjective norms, and perceived behavioral control partially mediated the relationship between risk aversion and intention. Lastly, the multi-group analysis revealed that gender and financial literacy did not moderate the association between risk aversion and intention.
Korean clinical practice guidelines for diagnostic and procedural sedation

Safe and effective sedation depends on various factors, such as the choice of sedatives, sedation techniques used, experience of the sedation provider, degree of sedation-related education and training, equipment and healthcare worker availability, the patient’s underlying diseases, and the procedure being performed. The purpose of these evidence-based multidisciplinary clinical practice guidelines is to ensure the safety and efficacy of sedation, thereby contributing to patient safety and ultimately improving public health. These clinical practice guidelines comprise 15 key questions covering various topics related to the following: the sedation providers; medications and equipment available; appropriate patient selection; anesthesiologist referrals for high-risk patients; pre-sedation fasting; comparison of representative drugs used in adult and pediatric patients; respiratory system, cardiovascular system, and sedation depth monitoring during sedation; management of respiratory complications during pediatric sedation; and discharge criteria. The recommendations in these clinical practice guidelines were systematically developed to assist providers and patients in sedation-related decision making for diagnostic and therapeutic examinations or procedures. Depending on the characteristics of primary, secondary, and tertiary care institutions as well as the clinical needs and limitations, sedation providers at each medical institution may choose to apply the recommendations as they are, modify them appropriately, or reject them completely.
Reconfigurable Millimeter-Wave Reflectarray Based on Low-Loss Liquid Crystals

This article reports on the development and evaluation of a reconfigurable millimeter-wave reflectarray (RA) based on liquid-crystal (LC) substrate operating in the D-band (105–125 GHz). The RA is composed of a high-impedance surface (HIS) with a meta-array of <inline-formula> <tex-math notation="LaTeX">$33\times 29$ </tex-math></inline-formula> patches on a 2-mm-thick quartz substrate, separated from the ground plane (GP) by a 40-<inline-formula> <tex-math notation="LaTeX">$\mu \text{m}$ </tex-math></inline-formula>-thick LC layer. A novel LC composition with low dielectric losses (< 0.003) and high dielectric anisotropy (<inline-formula> <tex-math notation="LaTeX">$>$ </tex-math></inline-formula>1.3) has been developed for operation at millimeter waves. The results demonstrate a reflection phase tunability of 210° and low insertion losses of 2.5 dB. Furthermore, the device was demonstrated as a proof of concept for 1-D beam-steering applications, exhibiting an operational bandwidth of 12 GHz.
Effects of northern and southern components of the East Asian winter monsoon variability on SST changes in the western North Pacific

The present study investigates the impacts of the two components of the East Asian winter monsoon (EAWM) variability on sea surface temperature (SST) changes in the western North Pacific. When the EAWM is stronger than normal, significant negative SST anomalies form in the East Asian marginal seas and subtropical western North Pacific and persist from winter to the following spring. It is found that winter‐spring SST anomalies in the Yellow Sea and the Japan Sea have a close association with the northern component of the EAWM variability, whereas the southern component has a large impact on SST changes in subtropical western North Pacific. The two components induce SST anomalies through both surface heat flux and oceanic advection changes. The surface latent heat flux is predominantly responsible for SST changes. The oceanic advection has a secondary contribution to the SST change in subtropical western North Pacific associated with the northern component and in the Japan Sea associated with the southern component. The surface latent heat flux anomalies associated with the northern component are induced through changes in both wind speed and sea‐air humidity difference, and those associated with the southern component are induced mainly through changes in sea‐air humidity difference north of 20°N. The SST anomalies induced by the northern component are mostly independent of El Niño–Southern Oscillation (ENSO). While ENSO has a large effect on the SST anomalies in open oceanic regions, the southern component has a dominant contribution independent of ENSO to the SST anomalies in the marginal seas.
The evolution characteristics of the extreme precipitation in Huaihe river basin during 1960-2008

This paper studied the temporal and spatial variations of extreme precipitation in Huaihe river basin from 1960 to 2008 with the geo-spatial statistics,time series analysis and trends in diagnosis and other methods.The results showed that the extreme precipitation,precipitation intensity and the days of heavy rainfall had not significantly changed in annual and seasonal trend.The incidents without precipitation lasting over 15 d were increasing from south to north about 2-5 times per year,it happened the most in winter and the least in summer.The events with precipitation lasting over 5 d were increasing from northeast to southwest about 1-8 times per year.In the northwest of Huangchuan-Zhengyang-Zhengzhou this kind of events were the most in the fall,in other areas the events were the least in summer.In the more than 40% of sites the chance with no persistant precipitation had increased significantly.The climate trend rate was 0.22-0.60 times/a.It occurred the most in the 1970s during abruptly climatic change.The events of precipitation reduced obviously over 30% of the sites.The climate trend rate was-0.24 to-0.70 times/a,no abruptly climatic change was found.There were no obvious relationship between persistant(no) precipitation events and the annual precipitation.
The Subjective Difficulty of Tapping to a Slow Beat

The current study investigates the slower limit of rhythm perception and participants subjective difficulty when tapping to a slow beat. Thirty participants were asked to tap to metronome beats ranging in tempo from 600 ms to 3000 ms between each beat. After each tapping trial the participants rated the difficulty of keeping the beat on a seven point scale ranging from “very easy” to “very difficult”. The result strongly support the notion that subjective difficulty increased with slower tempo as this was the case for all participants. While rated difficulty increased monotonically as a function of tempo the largest increase was between the tempo of 1200 ms and 1800 ms. This is in line with earlier reports on where tapping starts to feel laborious and supports the notion that there is a qualitative difference between tapping at fast (< 1200 ms between each beat) and slow (> 2400 between each beat) tempi. A mixed model analysis showed that tempo, tapping error and percentage of reactive responses all affected the participants rating of difficulty. Of these, tempo was by far the most influential factor, still participants were, to some degree, sensitive to their own tapping errors which then influenced their subsequent difficulty rating.
Selection of Sugar Cane Varieties with a Low Heavy Metal Accumulation Ability for the Ecological Remediation of Contaminated Farmland

Abstract: How to best use farmland contaminated with low to moderate levels of heavy metals remains a challenge in many parts of the world. Here, we screened sugar cane varieties to identify those with a low ability to accumulate heavy metals and with high tolerance. These trials were conducted in arsenic (As), lead (Pb) and Cadmium (Cd) contaminated farmland in IIuanjiang County, Guangxi Zhuang Autonomous Region, China. We tested seven varieties and found that cultivar Guiyin9 had the highest cane stem yield (187.5 t ha-1) and sugar content (27 t ha-1). The concentrations of As, Pb and Cd in the cane juice of Guiyin9 were all below the maximum limit for contaminants in food. Because Guiyin9 showed low accumulation of the heavy metals tested here and produced a high cane stem yield, this cultivar could be planted as a valuable crop in large areas of southern China contaminated with low to moderate levels of heavy metals.