Miracle-dz/UniFAR-FTUs huggingface dataset:
Bankart Repair Versus Latarjet Procedure for Recurrent Anterior Shoulder Instability: A Systematic Review and Meta-analysis of 3275 Shoulders

Background: Little consensus is available regarding the standard treatment for recurrent anterior instability of the shoulder. Typically, treatment selection has been based on training and tradition rather than the available evidence. Purpose: This study aimed to compare the clinical outcomes between arthroscopic Bankart procedure and the Latarjet procedure in the treatment of recurrent anterior shoulder instability with emphasis on follow-up time. Study Design: Systematic review and meta-analysis. Methods: We searched PubMed, Cochrane Central Register of Controlled Trials, Scopus, Ovid, and Web of Science up to January 2018 and included studies that compared arthroscopic Bankart versus Latarjet for treatment of anterior shoulder instability. Continuous data, such as operative time and patient-reported outcomes, were pooled as mean differences (MDs), whereas dichotomous data, such as recurrence, revision, redislocation, arthropathy, infection, and hematoma, were pooled as risk ratios (RRs), with 95% CIs. Results: Pooling data from 7 cohort studies (3275 patients) showed that arthroscopic Bankart was associated with a higher risk of redislocation (RR, 2.74; 95% CI, 1.48-5.06; P = .03), a higher risk of recurrence (RR, 2.87; 95% CI, 1.91-4.30; P < .0001), and a lower risk of infection (RR, 0.16; 95% CI, 0.06-0.43; P = .0002) compared with Latarjet, while the effect size did not favor arthroscopic Bankart or Latarjet in terms of Rowe score (MD, 0.22; 95% CI, –5.64 to 6.08; P = .94), revision (RR, 0.34; 95% CI, 0.08-1.39; P = .13), and hematoma (RR, 0.20; 95% CI, 0.03-1.19; P = .07). The effect estimate showed a pronounced advantage for Latarjet from 6 to 10 years postoperatively in terms of recurrence and redislocation (RR, 3.00; 95% CI, 1.98-4.56 and RR, 2.85; 95% CI, 1.51-5.38, respectively). Conclusion: Our results showed that Latarjet had less risk of recurrence and redislocation with longer follow-up time. Both procedures were comparable in terms of Rowe score, the need for revision, and postoperative hematoma formation, whereas Bankart repair was associated with a lower risk of infection.
Development of a decisional flowchart for meaningful patient involvement in Health Technology Assessment

Abstract Introduction This paper aims to describe the development of a flowchart to guide the decisions of researchers in the Spanish Network for Health Technology Assessment of the National Health System (RedETS) regarding patient involvement (PI) in Health Technology Assessment (HTA). By doing so, it reflects on current methodological challenges in PI in the HTA field: how best to combine PI methods and what is the role of patient-based evidence. Methods A decisional flowchart for PI in HTA was developed between March and April 2019 following an iterative process, reviewed by the members of the PI Interest Group and other RedETS members and validated during an online deliberative meeting. The development of the flowchart was based on a previous methodological framework assessed in a pilot study. Results The guidelines on how to involve patients in HTA in the RedETS were graphically represented in a flowchart. PI must be included in all HTA reports, except those that assess technologies with no relevant impact on patients’ experiences, values, and preferences. Patient organizations or expert patients related to the topic of the HTA report must be identified and invited. These patients can participate in protocol development, outcomes' identification, assessment process, and report review. When the technology assessed affects in a relevant way patient experiences, values, and preferences, patient-based evidence should be included through a systematic literature review or a primary study. Conclusions The decisional flowchart for PI in HTA contributes to the current methodological challenges by proposing a combination of direct involvement and patient-based evidence.
Pantoea ananatis carotenoid production confers toxoflavin tolerance and is regulated by Hfq‐controlled quorum sensing

Carotenoids are widely used in functional foods, cosmetics, and health supplements, and their importance and scope of use are continuously expanding. Here, we characterized carotenoid biosynthetic genes of the plant‐pathogenic bacterium Pantoea ananatis, which carries a carotenoid biosynthetic gene cluster (including crtE, X, Y, I, B, and Z) on a plasmid. Reverse transcription–polymerase chain reaction (RT‐PCR) analysis revealed that the crtEXYIB gene cluster is transcribed as a single transcript and crtZ is independently transcribed in the opposite direction. Using splicing by overlap extension with polymerase chain reaction (SOE by PCR) based on asymmetric amplification, we reassembled crtE–B, crtE–B–I, and crtE–B–I–Y. High‐performance liquid chromatography confirmed that Escherichia coli expressing the reassembled crtE–B, crtE–B–I, and crtE–B–I–Y operons produced phytoene, lycopene, and β‐carotene, respectively. We found that the carotenoids conferred tolerance to UV radiation and toxoflavin. Pantoea ananatis shares rice environments with the toxoflavin producer Burkholderia glumae and is considered to be the first reported example of producing and using carotenoids to withstand toxoflavin. We confirmed that carotenoid production by P. ananatis depends on RpoS, which is positively regulated by Hfq/ArcZ and negatively regulated by ClpP, similar to an important regulatory network of E. coli (HfqArcZ →RpoS Ͱ ClpXP). We also demonstrated that Hfq‐controlled quorum signaling de‐represses EanR to activate RpoS, thereby initiating carotenoid production. Survival genes such as those responsible for the production of carotenoids of the plant‐pathogenic P. ananatis must be expressed promptly to overcome stressful environments and compete with other microorganisms. This mechanism is likely maintained by a brake with excellent performance, such as EanR.
Efficacy of ustekinumab for active perianal fistulizing Crohn’s disease: a systematic review and meta-analysis of the current literature

Abstract Background Although the number of biological therapies for the treatment of Crohn’s disease (CD) is rapidly increasing, their efficacy in inducing healing of fistulas in perianal Crohn’s disease (pCD) is practically unknown, although they occur in up to 50% of patients with CD. Objective We aimed to investigate the clinical effectiveness of ustekinumab for pCD in a systemic review and meta-analysis. Methods Studies describing the efficacy of ustekinumab on fistulas in pCD in PubMed and EMBASE database from inception until 22 September 2020, were assessed in a systemic review and meta-analysis. The random-effect model was applied for the meta-analysis. Results The systematic review of the current literature yielded 2,243 studies of which nine studies with a total of 396 patients were found eligible for inclusion. The pooled proportions of patients experiencing fistula response were 41.0% (95% CI 23.9–60.6%9), I 2 = 85%, 39.7% (95% CI 24.3–57.4%), I 2 = 69% and 55.9% (95% CI 40.8–69.9%, I 2 = 67% at weeks 8, 24, and 52, respectively. Regarding fistula remission, the pooled proportions were 17.1% (95% CI 8.1–32.7%), I 2 = 45%, 17.7% (95% CI 1.8–71.9%), I 2 = 68%, and 16.7% (95% CI 3.0–56.5%, I 2 = 51% at week 8, 24, and 52, respectively. Conclusion In this systematic review with meta-analysis, we found a signal of efficacy of ustekinumab on fistulizing pCD, emphasizing that these patients might benefit from this therapy.
Nurse Sensemaking for Responding to Patient and Family Safety Concerns.

BACKGROUND Hospitals need to prevent, respond to, and learn from safety risks and events perceived by patients and families, who in turn rely on nurses to respond to and report their safety concerns. OBJECTIVES To describe the process by which bedside nurses evaluate and determine the appropriate response to safety concerns expressed by patients or their families. METHODS A qualitative design was employed. We recruited inpatient bedside nurses in an 811-bed Midwest academic medical center. Nurses provided demographic information and participated in semistructured interviews designed to elicit narratives related to evaluation and response to patient- or family-expressed safety concerns. Data analysis and interpretation were guided by grounded theory. RESULTS We enrolled 25 nurses representing 22 units. Based on these nurses' experiences, we developed a grounded theory explaining how nurses evaluate a patient or family safety concern. Nurses make sense of the patient's or family's safety concern in order to take action. Achieving this goal requires evaluation of the meaningfulness and reasonableness of the concern, as well as the potential effect of the concern on the patient. Based on this nursing evaluation, nurses respond in ways designed to (a) manage emotions, (b) immediately resolve concerns, (c) involve other team members, and (d) address fear or uncertain grounding in reality. Nurses reported routinely handling safety concerns at the bedside without use of incident reporting. DISCUSSION Safety requires an interpersonal and evaluative nursing process with actions responsive to patient and family concerns. Safety interventions designed to be used by nurses should be developed with the dynamic, cognitive, sensemaking nature of nurses' routine safety work in mind. Being sensitive to the vulnerability of patients, respecting patient and family input, and understanding the consequences of dismissing patient and family safety concerns is critical to making sense of the situation and taking appropriate action to maintain safety. Measuring patient safety or planning improvement based on patient or family expression of safety concerns would be a difficult undertaking using only standard approaches. A more complex approach incorporating direct patient engagement in data collection is necessary to gain a complete safety picture.
Hydrogen Absorption/Desorption Mechanism in Potassium Alanate (KAlH4) and Enhancement by TiCl3 Doping

Thermodynamic and kinetic properties of potassium alanate (KAlH4) are investigated. Its pressure-composition-isotherm measurement exhibits two plateaus for hydrogen absorption/desorption in KAlH4, with gravimetric hydrogen densities of 1.2 +/- 0.1 and 2.6 +/- 0.2 mass% and reaction enthalpies of 81 and 70 kJ.mol(-1) H-2, respectively. However, the nonisothermal decomposition of KAlH4 occurs through three endothermic events at temperatures of 294, 311, and 347 degrees C with the release of hydrogen. Whereas the high temperature event is clearly attributed to K3AlH6 decomposition, the low temperature events occur by two reactions, denoting the existence of an intermediate phase during KAlH4 decomposition. FTIR measurements suggest that this intermediate phase is a KyAlHx compound (y >= 1, x >= 4) with a high coordination about the aluminum. TiCl3-doped KAlH4 also exhibits three decomposition events, but with significant reduction of desorption temperatures (similar to 50 degrees C) as well as activation energies that is attributed to particle size reduction and creation of charged vacancies.
YAP/TAZ deficiency reprograms macrophage phenotype and improves infarct healing and cardiac function after myocardial infarction

Adverse cardiac remodeling after myocardial infarction (MI) causes structural and functional changes in the heart leading to heart failure. The initial post-MI pro-inflammatory response followed by reparative or anti-inflammatory response is essential for minimizing the myocardial damage, healing, and scar formation. Bone marrow–derived macrophages (BMDMs) are recruited to the injured myocardium and are essential for cardiac repair as they can adopt both pro-inflammatory or reparative phenotypes to modulate inflammatory and reparative responses, respectively. Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) are the key mediators of the Hippo signaling pathway and are essential for cardiac regeneration and repair. However, their functions in macrophage polarization and post-MI inflammation, remodeling, and healing are not well established. Here, we demonstrate that expression of YAP and TAZ is increased in macrophages undergoing pro-inflammatory or reparative phenotype changes. Genetic deletion of YAP/TAZ leads to impaired pro-inflammatory and enhanced reparative response. Consistently, YAP activation enhanced pro-inflammatory and impaired reparative response. We show that YAP/TAZ promote pro-inflammatory response by increasing interleukin 6 (IL6) expression and impede reparative response by decreasing Arginase-I (Arg1) expression through interaction with the histone deacetylase 3 (HDAC3)-nuclear receptor corepressor 1 (NCoR1) repressor complex. These changes in macrophages polarization due to YAP/TAZ deletion results in reduced fibrosis, hypertrophy, and increased angiogenesis, leading to improved cardiac function after MI. Also, YAP activation augmented MI-induced cardiac fibrosis and remodeling. In summary, we identify YAP/TAZ as important regulators of macrophage-mediated pro-inflammatory or reparative responses post-MI.
Changes in Racial Disparities in Mortality After Cancer Surgery in the US, 2007-2016

Key Points Question What are the disparities in mortality after cancer surgery between Black and White patients from 2007 to 2016? Findings In this cross-sectional study of 870 929 cancer operations over 10 years, overall mortality rates after cancer surgery decreased for both Black and White patients; however, no significant narrowing of the mortality gap between Black and White patients was observed. Mortality improvements were largely associated with within-hospital factors. Meaning Overall, mortality rates following cancer surgery appear to be improving for both Black and White patients, but the gap in cancer surgery mortality rates between Black and White patients remains and does not appear to be narrowing.
Alumina nanotemplate fabrication on silicon substrate

Alumina nanotemplates integrated on silicon substrate with pore diameters of 12? 100? nm were prepared by galvanostatic (constant current) anodization. High current density (e.g.? 100? mA? cm? 2) promoted a highly ordered hexagonal pore structure with fast formation rate independent of anodizing solution. Alumina formation rates of 2000 and 1000? nm? min? 1 were achieved at current densities of 100 and 50? mA? cm? 2, respectively. These rates were approximately two orders of magnitude greater than other reports in the literature. Different electrolytes of sulfuric acid (1.8? 7.2? M), oxalic acid (0.3? M) and mixed solutions of sulfuric and oxalic acids were evaluated as anodizing solutions. At fixed current density, sulfuric acid promoted smaller pore diameter with lower porosity than mixed acids and oxalic acid. The I? V characteristics of aluminium anodization show the measured voltages at given current densities strongly depend on solution composition, operating temperature, and bath agitation. The pore diameter of the silicon-integrated alumina nanotemplate varied linearly with measured voltage with a slope of 2.1? nm? V? 1, which is slightly smaller than reported data.
The Dynamic Changes of Gut Microbiota during the Perinatal Period in Sows

Simple Summary The gut microbiota in sows is important for the health of the host, and potential benefits may also be transferred to piglets during pregnancy. Therefore, systematic studies investigating the changes in the gut microbiota of sows are needed to elucidate the microbial compositions and functions. This study was conducted at 12 time points to investigate the temporal variations in the gut microbiota of sows using 16S rRNA sequencing. The results provided important information for the gut microbiota of sows during different perinatal periods. Abstract The gut microbiota in sows is important for the health of the host, and potential benefits may also be transferred to piglets during pregnancy. Therefore, systematic studies investigating the changes in the gut microbiota of sows are needed to elucidate the microbial compositions and functions. This study was conducted at 12 time points to investigate the temporal variations in gut microbiota on Days 27, 46, 64, 81, 100, and 113 during gestation (G) and Days 3, 5, 7, 10, 14, and 21 during lactation (L). Results suggested that the gut microbiota changed across the perinatal period with microbial function and abundance varying between the prenatal and postnatal periods. The alpha diversity was higher in the postnatal period than in the prenatal period. Thirty-eight genera were distributed between the two periods with Methanobrevibacter, Desulfovibrio, Akkermansia, and Turicibacter being enriched in the prenatal period while Eubacterium, Actinobacillus, Paludibacter, Butyricimonas, Megasphaera, Succiniclasticum, Acidaminococcus, and Rummeliibacillus were enriched in the postnatal period. Analysis done at the different time points of the prenatal period suggested that Days 27 and 113 had more microbial biomarkers than other days. Bacteroidales, Bacteroidia, and Prevotella were enriched on the 27th day, while bacteria belonging to the Clostridium and Ruminococcaceae were enriched on the 113th day. On the other hand, Clostridiales, Ruminococcaceae, Clostridia, and unclassified Christensenellaceae were enriched three days after delivery. Predicted microbial KO functions were also more enriched on Day 27 of the gestation period and Day 3 of the lactation period. Random forest, a machine learning method, was used to identify the top five important genera of Megasphaera, Stenotrophomonas, Phyllobacterium, Catenibacterium, and Turicibacter, while the most important function was arginine and proline metabolism. These systematic results provide important information for the gut microbiota of sows.
Extensive Cortical Convergence to Primate Reticulospinal Pathways

Early evolution of the motor cortex included development of connections to brainstem reticulospinal neurons; these projections persist in primates. In this study, we examined the organization of corticoreticular connections in five macaque monkeys (one male) using both intracellular and extracellular recordings from reticular formation neurons, including identified reticulospinal cells. Synaptic responses to stimulation of different parts of primary motor cortex (M1) and supplementary motor area (SMA) bilaterally were assessed. Widespread short latency excitation, compatible with monosynaptic transmission over fast-conducting pathways, was observed, as well as longer latency responses likely reflecting a mixture of slower monosynaptic and oligosynaptic pathways. There was a high degree of convergence: 56% of reticulospinal cells with input from M1 received projections from M1 in both hemispheres; for SMA, the equivalent figure was even higher (70%). Of reticulospinal neurons with input from the cortex, 78% received projections from both M1 and SMA (regardless of hemisphere); 83% of reticulospinal cells with input from M1 received projections from more than one of the tested M1 sites. This convergence at the single cell level allows reticulospinal neurons to integrate information from across the motor areas of the cortex, taking account of the bilateral motor context. Reticulospinal connections are known to strengthen following damage to the corticospinal tract, such as after stroke, partially contributing to functional recovery. Extensive corticoreticular convergence provides redundancy of control, which may allow the cortex to continue to exploit this descending pathway even after damage to one area. SIGNIFICANCE STATEMENT The reticulospinal tract (RST) provides a parallel pathway for motor control in primates, alongside the more sophisticated corticospinal system. We found extensive convergent inputs to primate reticulospinal cells from primary and supplementary motor cortex bilaterally. These redundant connections could maintain transmission of voluntary commands to the spinal cord after damage (e.g., after stroke or spinal cord injury), possibly assisting recovery of function.
Evaluation of Physical Properties of a Metakaolin-Based Alkali-Activated Binder Containing Waste Foam Glass

Foam glass production process redounds to large quantities of waste that, if not recycled, are stockpiled in the environment. In this work, increasing amounts of waste foam glass were used to produce metakaolin-based alkali-activated composites. Phase composition and morphology were investigated by means of X-ray powder diffraction, Fourier-transform infrared spectroscopy and scanning electron microscopy. Subsequently, the physical properties of the materials (density, porosity, thermal conductivity and mechanical strength) were determined. The analysis showed that waste foam glass functioned as an aggregate, introducing irregular voids in the matrix. The obtained composites were largely porous (>45%), with a thermal conductivity coefficient similar to that of timber (<0.2 W/m∙K). Optimum compressive strength was achieved for 10% incorporation of the waste by weight in the binder. The resulting mechanical properties suggest the suitability of the produced materials for use in thermal insulating applications where high load-bearing capacities are not required. Mechanical or chemical treatment of the waste is recommended for further exploitation of its potential in participating in the alkali activation process.
Size Invariance of Polyelectrolyte Dendrimers

To quantify the swelling response of polyelectrolyte dendrimers in aqueous solutions as affected by changes in solution conditions, we have studied eighth generation, G8, poly(amidoamine) (PAMAM) dendrimers in D2O using small-angle neutron scattering. The charge density is manipulated by varying the pH of the solution in order to protonate and deprotonate the primary and tertiary amines. The coherent scattered intensity at high q values yields size information from the form factor of individual dendrimers. The distance distribution functions of the dendrimers in a variety of experimental situations were determined by indirect Fourier transform. For all the conditions studied, we find that the size of G8 dendrimers is essentially insensitive to variations of the pH (4.7 < pH < 10.1) and of ionic strength (up to 3 M of NaCl). In all cases, the scattering curves yield density profiles that correspond well to a uniform sphere with a radius of gyration RG = 4.0 ± 0.15 nm. We conclude that the dendrimer size is.