Miracle-dz/UniFAR-FTUs huggingface dataset:
STAT3 Localizes in Mitochondria-Associated ER Membranes Instead of in Mitochondria

Signal Transducer and Activator of Transcription 3 (STAT3) is a transcription factor (TF) that regulates a variety of biological processes, including a key role in mediating mitochondrial metabolism. It has been shown that STAT3 performs this function by translocating in minute amounts into mitochondria and interacting with mitochondrial proteins and genome. However, whether STAT3 localizes in mitochondria is still up for debate. To decipher the role of mitochondrial STAT3 requires a detailed understanding of its cellular localization. Using Percoll density gradient centrifugation, we surprisingly found that STAT3 is not located in the mitochondrial fraction, but instead, in the mitochondria-associated endoplasmic reticulum membrane (MAM) fraction. This was confirmed by sub-diffraction image analysis of labeled mitochondria in embryonic astrocytes. Also, we find that other TFs that have been previously found to localize in mitochondria are also found instead in the MAM fraction. Our results suggest that STAT3 and other transcriptional factors are, contrary to prior studies, consolidated specifically at MAMs, and further efforts to understand mitochondrial STAT3 function must take into consideration this localization, as the associated functional consequences offer a different interpretation to the questions of STAT3 trafficking and signaling in the mitochondria.
Multibump solutions for nonlinear Schrödinger‐Poisson systems

In this paper, we study the following Schrödinger‐Poisson equations: −ε2Δu+V(x)u+K(x)ϕu=|u|p−2u,x∈R3,−ε2Δϕ=K(x)u2,x∈R3, where p∈(4,6) , ε>0 is a parameter and V and K satisfy the critical frequency conditions. By using variational methods and penalization arguments, we show the existence of multibump solutions for the above system. Furthermore, the heights of these bumps are different order.
Financial Inclusion and Achievements of Sustainable Development Goals (SDGs) in ASEAN

Objective - Financial Inclusion is an essential agenda at the ASEAN level. Increasing financial inclusion aims to develop the economic capacity of the population to reduce poverty and encourage income distribution. This study aims to analyze the relationship of financial inclusion to the achievement of Sustainable Development Goals (SDGs) in the aspect of poverty alleviation in ASEAN.Methodology/Technique - This study uses a quantitative approach. The data used is secondary data in the period between 2010 and 2018. Data processing uses multiple regression. The financial inclusion dimensions analyzed are the socioeconomic dimension and the infrastructure dimension.Findings - Financial Inclusion has a negative and significant relationship with the achievement of sustainable development goals (SGDs) in the aspect of poverty alleviation in ASEAN.Novelty - The statement that the development of countries in ASEAN to realize SDGs on poverty eradication becomes very important. This study is essential for policymakers regarding poverty alleviation and financial inclusion development. This study contributes to the financial inclusion literature in ASEAN with an emphasis on the socioeconomic dimension.
Hospital doctors' management of psychological problems at a Nigerian tertiary health institution

A questionnaire was sent to all consenting doctors at the University of Ilorin Teaching Hospital, Nigeria. It asked about their management of psychological problems in their clinical practice. Over 90% would welcome more time to talk to patients and agreed that psychological and social factors should be routinely assessed and recorded for patients. Most respondents would refer patients with depression or disturbed behaviours. ‘Ineffective treatment’ and ‘dislike of psychiatric referral’ were not the main reasons for non-referral. A majority of the doctors had initiated treatment for anxiety and insomnia but not for alcohol withdrawal, psychosis, acute confusional state or depression. Doctors' awareness of ‘the impact of psychological factors on the course of physical illness' was high. To sustain this high level of awareness and encourage referral, in-house psychoeducational training of hospital doctors should be intensified. In addition, an increased doctor/patient ratio, public education to reduce stigma and a well developed liaison psychiatric service are imperative.
Temporal Changes of the Inner Core From Globally Distributed Repeating Earthquakes

Time‐dependent travel times of seismic waves traversing the inner core from repeating earthquakes provided compelling evidence for an inner core differential motion. Here we conducted a systematic search for strong repeating earthquakes in the last three decades to examine the global pattern of temporal changes of the inner core. We performed extensive analyses on the quality of the repeating earthquakes and quantified the error (σic) of travel time measurements from all possible sources except the inner core temporal changes. We set 2σic as a threshold for judging whether an inner core temporal change is significant. No significant temporal changes were found in most parts of the inner core, but large temporal changes (over 3σic) were observed beneath four regions in Northern Hemisphere (North Atlantic, Northeast Pacific, Russian Far East/Sea of Okhotsk, and Europe/North Africa), besides the well‐known Central America anomaly in previous studies. Most large temporal changes were associated with time lapses of over 6 years and smaller distances, possibly resulting from the rotation shifting the laterally varying top 300 km of the inner core. A new path sampling North Atlantic suggested a small‐scale and steep lateral velocity gradient of the inner core and a slow eastward inner core rotation of 0.051°/year. Small‐scale lateral variations may reconcile large difference in the estimates of the inner core rotation rate. We also observed enigmatic very large abrupt temporal changes (as short as 44 days), which may be related to disturbances caused by the great Sumatra earthquakes.
Modeling change implementation behaviors: teachers’ affective and attitudinal reactions to change in Turkey

ABSTRACT Theorizing on the Affective Events Theory this study aims at (1) exploring the relationships among trust, change-related positive and negative affect, commitment to change, and job satisfaction and, (2) investigating their impacts on the change implementation behaviors of teachers in the second-order educational change context. The study was designed as a correlational one and took place in 85 public schools randomly selected through stratified cluster sampling from 13 school districts in Ankara, Turkey. Structural Equation Modeling was used to analyze the data which were collected from a sample of 663 public school teachers. The results verified the superior role of trust in top management in shaping change-related reactions rather than work-related one and documented the unique roles of positive and negative change-related affect in constructing teachers’ change and work-related attitudes. The results also revealed that affective and attitudinal responses of change receivers are influential in predicting the degree of their change implementation behaviors. These findings indicate the need for building trust at both school and system levels while investing in positive change-related affect for more desired outcomes of educational change interventions.
Improved similarity measure in case-based reasoning: a case study of construction cost estimation

Applied a hybrid approach using genetic algorithms (GAs) for a case-based retrieval process in order to increase the overall improved cost accuracy for a case-based library. The paper aims to discuss this issue. ,A weight optimization approach using case-based reasoning (CBR) with proposed GAs for developing the CBR model. GAs are used to investigate optimized weight generation with an application to real project cases. ,The proposed CBR model can reduce errors consistently, and be potentially useful in the early financial planning stage. The authors suggest the developed CBR model can provide decision-makers with accurate cost information for assessing and comparing multiple alternatives in order to obtain the optimal solution while controlling cost. ,The system can operate with more accuracy or less cost, and CBR can be used to better understand the effects of factor interaction and variation during the developed system’s process.
Electrophysiology in Ménière’s Disease

Ménière’s disease (MD) is a progressive inner ear disorder that affects at least 0.2% of the population in EUA. The symptoms triad of fluctuating hearing loss, tinnitus, and vertigo was described by Prosper Ménière for more than a century and its pathophysiology is still unknown. MD has a fluctuating course and in many cases, difficult clinical management. Progressive hearing loss and intense dizzying seizures becomes more frequent as the disease progresses. All of this increases the challenges of accurate identification and has probably led to the trial of several tests for identifying MD. The tests are useful tools to assist the otolaryngologist both in diagnosis and prognosis of MD. These tests includes audiometry, otoacustic emission (OAE), electrocochleography (EcochG), vestibular evoked myogenic potentials (VEMP), cochlear hydrops analysis masking procedure (CHAMP) and video head impulse test (vHIT).
ULTRACYTOCHEMICAL STUDIES ON THE EFFECTS OF CYCLIC AMP ON THE LYSOSOMAL SYSTEM IN HEPATIC CELLS OF MICE

The effects of cyclic AMP on the lysosomal system were studied by electron microscopy combined with cytochemical methods in the hepatocytes of mice. Cyclic AMP dissolved in Krebs-Ringer bicarbonate buffer at a concentration of 6 >< 10-7-3 >< 10"3 M was perfused through the portal vein for 15 min at the rate of 3—6 ml/min. After perfusion fixation with a mixture of glutaraldehyde and paraformaldehyde, the liver was examined partly by routine electron microscopy, and partly after an ultracytochemical demonstration of acid phosphatase and thiamine pyrophosphatase by the lead method. Thick (1-2 pm) epon sections were also investigated under a high voltage electron microscope (1,000 kV) and stereo-pair pictures were taken in order to obtain the three-dimensional structure of lysosomes. The observations indicate that cyclic AMP enhanced the autophagic process and autophagolysosome formation in the hepatic parenchymal cells of mice. During the autophagolysosome formation the lysosomal wrapping mechanism was observed, which was not found in the controls. It was deduced that the enhanced autophagic process and the lysosomal wrapping mechanism observed previously by glucagon administration is mediated by cyclic AMP. In addition to changes in lysosomes, cylinderization of the Golgi apparatus was observed, the significance of which remains to be elucidated.
Consequentialism and the boundary of morality

ABSTRACT A series of our experimental studies show that some actions which consequentialists would treat as morally right or wrong were not regarded by ordinary people as a matter of morality. These results suggest that there is a divide between the moral and the non-moral that ordinary people intuitively believe in but that consequentialism seems unable to accommodate. We argue that the root of this conflict lies in the inclusion of non-moral value in the consequentialist theory of the good, which causes consequentialism to deny, in all cases involving primarily non-moral value, a moral/non-moral divide. We argue further that there is no good theoretical reason (other than that which motivates consequentialism) to think that such a divide is unjustified. Therefore, consequentialism faces a problem: any version of consequentialism that allows non-moral value into the theory of the good will be at odds with a substantial number of seemingly justified intuitions.
Knowledge and Self Perception about Preventive Dentistry among Indonesian Dental Students

Objective: To investigate the knowledge and self-perception of Indonesian dental students in giving oral health education and preventive treatment. Material and Methods: This was a cross sectional study, with 208 clinical students (54 males and 154 females). Knowledge and self-perception of preventive dentistry was assessed using multiple choice questionneire based on a four-point likert scale written in Indonesia, at Dental Hospital of Hasanuddin University. Assessment of preventive dentistry knowledge on clinical students by answering 14 questions, while self-perception in providing oral health education and preventive treatment was assessed using general questions. Statistical evaluation was done using Chi-squared test and t test. The significance level was set at 5%. The analyses were performed with SPSS 12 statistical package. Results: Both male and female students are reported to have high competence in giving oral health education and preventive treatment (94-99%), but there was no significant difference between genders (p>0.05). Almost all questions were answered by agree or strongly agree. 75% of study participants disagreed with the statement that the use of fluoride toothpaste is more important than the brushing technique for dental caries prevention (PK2, p<0.05). Conclusion: The perceptions of clinical students participating in the study have high competence (94-99%) in providing education and preventive care to their patients, but there is still a lack of prevention knowledge.
Analytical Reformulation for Stochastic Unit Commitment Considering Wind Power Uncertainty With Gaussian Mixture Model

To capture the stochastic characteristics of renewable energy generation output, chance-constrained unit commitment (CCUC) model is widely used. Conventionally, analytical reformulation for CCUC is usually based on simplified probability assumption or neglecting some operational constraints, otherwise scenario-based methods are used to approximate probability with heavy computational burden. In this paper, Gaussian mixture model (GMM) is employed to characterize the correlation between wind farms and probability distribution of their forecast errors. In our model, chance constraints including reserve sufficiency and branch power flow bounds are ensured to be satisfied with predetermined probability. To solve this CCUC problem, we propose a Newton method based procedure to acquire the quantiles and transform chance constraints into deterministic constraints. Therefore, the CCUC model is efficiently solved as a mixed-integer quadratic programming problem. Numerical tests are performed on several systems to illustrate efficiency and scalability of the proposed method.
Portfolio Diversification and Oil Price Shocks: A Sector Wide Analysis

This paper investigates the time-varying relationship between the oil price and disaggregated stock market of India using Dynamic conditional correlation multivariate GARCH and Continuous Wavelet Transformation modelling approaches. Our findings reveal the evolving relationship between the oil price and disaggregated stock market. The correlations are generally volatile before the 2007-08 crisis but since then the correlations are positive implying no diversification benefits for the investors during rising oil prices. As emerging markets in general, and India in particular, is expected to increase its share of oil consumption in the world’s energy market, therefore for the stock market to grow, especially the oil-intensive industries, we recommend the government should increase its reliance on alternative energy resources. Furthermore, as rising oil prices can also have its adverse effect through exchange rate channel, we suggest the monetary policies should be time varying to manage the oil inflationary pressures arising out of extreme volatility in the oil prices.
Head Over Heels in Gastrointestinal Anatomy: A Case Study

Background: The classical teaching model consists of lectures where students passively receive information. In the flipped classroom, lecture content is available for students online, and the lecture time is utilised for problem solving and active learning. This project set out to compare these models in a "traditional" anatomy course. Summary of work: Activity logs for Year 2 recorded lectures in the anatomy of the gastrointestinal tract were downloaded from Moodle (VLE). Results of a mock topic test administered under exam conditions and student feedback were analysed. Summary of results: 61 participants submitted voluntarily to the written test; 38 (62.3%) had watched the online lectures. No difference was found in marks between students who did/did not participate (54.0+/-18.6 vs 59.9+/-14.1, p=0.1699) respectively. The response rate was 73%: All watched online lectures, 70% used them to replace contact teaching entirely on at least some occasions. 60% preferred video lectures, 51.2% of whom preferred full-face video recording of the traditional lecture, 16% audio alone and 18.6% a full flipped classroom model. 39.5% felt their performance was negatively affected by this approach due to their lack of motivation to engage with the lecture videos. Discussion: The similarity in student marks between the two teaching approaches suggests that the flipped classroom model may be a suitable alternative, especially when resources are limited. The preference of most students for the traditional model could suggest a reluctance to participate in active learning activities or room for improvement in the video lectures provided. Conclusions: The majority of students accessed online lectures. Those who did performed as well as those who did not in a mock test. Take home message: Flipped classroom teaching is an effective alternative to traditional anatomy teaching. Stoner R, Caruana E, Stabile I MedEdPublish https://doi.org/10.15694/mep.2017. 000107 Page | 2
Survival Analysis of Premature Infants Admitted to Neonatal Int ensiveCare Unit (NICU) in Northwest Ethiopia using Semi-Parametric Fr ailtyModel

In this research, the cox proportional hazard model and the semi-parametric gamma frailty model were compared on the survival of premature infants admitted to neonatal intensive care unit from December 29, 2011 to April 6, 2014. A retrospective study design was used to collect the data from patients chart. A frailty effect (θ=0.252, P-Value = 0.0031 < α=0.05) was obtained from the semi-parametric gamma frailty model, and mortality was depend within and across categories of premature infants based on their gestational age. The values of frailty were dispersed and hence induce greater heterogeneity in the infant hazards. Therefore, when there is heterogeneity, semi-parametric gamma frailty model could be used and lead to acceptable conclusions. Both models identifies Antenatal Care Visit, gravidity of (6-10), HIV status of mother, Respiratory Distress Syndrome, Prenatal Asphyxia, anemia and breastfeed initiated as the most determinant and statistically associated with time to death of premature infants admitted to NICU. Based on the model comparison analysis, semi-parametric gamma frailty was the best model to fit the data.
The Effect of Volunteer Demographics on Nonprofit Volunteer Retention

The Effect of Volunteer Demographics on Nonprofit Volunteer Retention by Keri VanOverschelde MS, Walden University, 2014 MPA, Hamline University, 2009 BS, Southwest Minnesota State University, 2004 Dissertation Submitted in Partial Fulfillment of the Requirements for the Degree of Doctor of Philosophy Industrial and Organizational Psychology Walden University November 2017 Abstract Nonprofit organizations rely upon volunteers to assist in achieving their mission andNonprofit organizations rely upon volunteers to assist in achieving their mission and reaching strategic operational goals. As the volunteer population in the United States has decreased, nonprofit organizations are challenged to recruit and retain volunteers. To improve operational efficiencies in nonprofit volunteer management, organizations need to implement more effective strategies to assign roles to volunteers and develop a better understanding of how those roles fit into volunteers’ lives and the value systems of individual volunteers. The functional theory of volunteer behavior characterizes the values, understanding, social, career, protective, and enhancement functions as they relate to an individual’s motivation for volunteering. To investigate how active volunteer demographics related to self-reported ratings of personal and social motivational functions, a multivariate analysis of variance, with designated follow-up post hoc tests, was used to address the research questions and associated hypotheses to provide a basis to make comparative statistical analysis to determine volunteer needs, values, and purpose based on age cohort, sex, race/ethnicity, and socioeconomic status. It was found that the functional aspect, career, was a significant determinate when focused on the demographics of age, gender, and socioeconomic status. Additionally, an interaction emerged with sex and age with career, social, understanding, and enhancement functional aspects. The results of the study will foster positive social change by increasing the understanding of how volunteer behavior impacts volunteer retention and recruitment, facilitating nonprofit organizations in their ability to effectively match volunteer skills with assignment, thereby maximizing their impact and longevity within the organization. The Effect of Volunteer Demographics on Nonprofit Volunteer Retention by
Dossier: Osteoporosis Osteopenia and osteoporosis in HIV+ patients, untreated or receiving

Abstract In the last few years there are increasing evidences suggesting that osteopenia and osteoporosis are frequent among HIV positive patients.Itisstillnotclearifthebonedemineralizationisadirectconsequenceofviralinfectionoroftheantiretroviraldrugs. Studiestodatethereforegive conﬂicting results. We performed a study to evaluate the prevalence of osteopenia and osteoporosis in HIV positive patients, eitheruntreated or receiving antiretroviral therapy, to asses the frequency of these conditions and the role of antiretroviral drugs. © 2004 Elsevier SAS.All rights reserved. Keywords: HIV infection; Osteopenia/osteoporosis; HAART 1. Introduction Osteoporosis is frequent among patients with HIV infec-tionbutwestilldonotunderstandwhetherthebonedeminer-alizationisadirectconsequenceofviralinfectionperseorofthe antiretroviral therapy [1]. Even before HAART becameavailable, there was evidence that HIV could directly infectbone cells [2,3] and slow bone turnover [4]. Once HAARTbegan to be used, there was an increasing number of reportssuggesting that bone metabolism might be closely related tothe use of these drugs, particularly protease inhibitors.Thus,osteopenia and osteoporosis in HIV positive patients stillinvolve many open questions.
Externalities and Spillovers from Sanitation and Waste Management in Urban and Rural Neighborhoods

Proper sanitation and waste management has important health benefits, both directly for the household making the decision and indirectly for its neighbors due to positive externalities. Nevertheless, construction and use of improved sanitation systems in much of the developing world continues to lag. Many recent interventions such as Community Led Total Sanitation (CLTS) have attempted to harness the power of social interactions to increase take-up of improved sanitation. Most evidence to date mobilizes social pressure in rural areas, yet evidence is more scarce in urban neighborhoods where high population density may lead to larger externalities from poor sanitation decisions. We review the recent literature on how sanitation decisions are inter-related within neighborhoods: the health externalities that sanitation decisions have on neighbors and the social decision spillovers that drive take-up. We explore potential explanations for the low take-up and maintenance of sanitation systems, including the possibility of non-linearities and thresholds in health externalities; the roles of social pressure, reciprocity, learning from others, and coordination in decision spillovers; and differences between urban and rural contexts.