Miracle-dz/UniFAR-FTUs huggingface dataset:
C-Reactive Protein versus Erythrocyte Sedimentation Rate: Implications Among Patients with No Known Inﬂammatory Conditions

Background: Measurements of C-reactive protein (CRP) concentration and erythrocyte sedimentation rate (ESR) are frequently ordered jointly in clinical practice. Aim: To investigate the factors associated with discordances between CRP concentration and ESR in adults. Methods: We conducted a cross-sectional study of 1472 adults with no known inﬂammatory disorders (44.5% male; median age, 52 years; range, 18–91 years), randomly selected from a municipality in Spain. The participants underwent simultaneous measurements of ESR, serum CRP, and interleukin-6 concentrations. Alcohol consumption, smoking, and physical activity were evaluated by questionnaire. Body mass index (BMI) measurement and metabolic syndrome criteria were available for all participants. Results: Most (n = 1123, 74.9%) of the participants showed normal CRP and ESR values. Sixty-nine (4.6%) participants showed high CRP and ESR values. Seventy-two (4.8%) participants showed a discordant pattern of high ESR and normal CRP values, which was associated with age after adjusting for sex, alcohol consumption, physical activity, BMI, and the presence of metabolic syndrome (odds ratio [OR], 1.052; 95% CI, 1.034–1.071; P < .001). A total of 208 (13.8%) participants showed a discordant pattern of high CRP and normal ESR values, which was associated with BMI after adjusting for covariates (OR, 1.099; 95% CI, 1.064–1.136; P < .001). BMI appeared to be the main determinant of serum CRP concentrations in this population. Serum interleukin-6 concentrations were positively associated with the discordant pattern of high CRP and normal ESR values. Conclusion: In this general adult population with no overt inﬂammatory disease, the discordant pattern of high ESR and normal CRP was associated with greater age, whereas the pattern of high CRP and normal ESR was associated with higher BMI. ( J Am Board Fam Med 2021;34:974–983.) the multivariate
Familial association of lung cancer with liver cancer in ﬁ rst-degree relatives

Purpose: Besides the smoking and occupational exposures, heritable factors have been proven to be a risk factor for lung cancer by several population-based studies, which would misestimate the risk of lung cancer. Patients and methods: To quantify the magnitude of the high risk of lung cancer with family history, we performed a case-based study with 1373 enrolled individuals, which may be more accurate than a population-based study. Results: Risk of lung cancer was higher in people with lung cancer family history than in the control group (OR 2.50, p <0.001). Individuals with family history of liver cancer also had a higher risk of lung cancer than the control group (OR 1.78, p =0.038) while there was no signi ﬁ cant difference within the individuals with family history of colorectal cancer, esophageal cancer, nasopharyngeal cancer or breast cancer. Furthermore, the risk of lung cancer in the subjects with early-onset cancers (age <50 years) was higher than the later-onset cancers (age ≥ 50 years), especially in individuals with family history of liver cancer (OR 9.24 vs 1.39). Risk of lung cancer in females with family history of lung cancer or liver cancer was higher than in males. Conclusion: The results of this study proved that the familial aggregation of lung cancer and liver cancer manifests higher risks of lung cancer, supporting the hypothesis that lung cancer and liver cancer are attributable to common familial predisposition.
identification of the new variant typing in a Swedish county before and after sequencing and multilocus sequence ompA by Chlamydia trachomatis Characterisation of

Objectives In 2006 a new variant of Chlamydia trachomatis (nvCT), with a deletion in the cryptic plasmid, was reported in Sweden. This deletion included the targets for the genetic diagnostic systems used in many clinical laboratories and resulted in thousands of falsenegative results. The aim of this study was to characterise consecutive Chlamydia tissue culturepositive samples from 2006 in Örebro County, after identification of the nvCT, and to compare the results from samples collected in the same county in 1999e2000. The study also aimed to evaluate the discriminatory capacity of multilocus sequence typing (MLST) compared with ompA sequencing. Methods ompA sequencing and MLST was used to characterise 100 consecutive Chlamydia tissue culture-
Motivic DT-invariants for the one loop quiver with potential

In this paper we compute the motivic Donaldson–Thomas invariants for the quiver with one loop and any potential. As the presence of arbi- trary potentials requires the full machinery of ˆ µ -equivariant motives, we give a detailed account of them. In particular, we will prove two results for the motivic vanishing cycle which might be of importance not only in Donaldson– Thomas theory.
T R U N C A T E D # (#') C H A I N S IN M U R I N E IgM Evidence that #' Chains Lack Variable Regions

The first immunoglobulin (Ig) chain to be expressed in developing B cells is the # chain (1-4). Light (L) 1 chain expression follows and results in the assembly of # and L chains to form IgM m o n o m e r s (#2L2) (5, 6). IgM is secreted as a pentamer, (#2L2)5 (reviewed in 7). The formation of pentameric IgM depends on disulfide bonding of one or more secretory ~ chains with another cellular component, the J chain (8-10), and involves the penultimate cysteine residue in the U chain terminus (11). Whether all IgM pentamers are structurally uniform is open to question, as recalled by an old controversy concerning the number and possible heterogeneity of antigen-binding sites in individual IgM antibodies. Reports of 10 equivalent antigen-binding sites (12-14) are at variance with reports of 10 nonequivalent antigen-binding sites; i.e., 5 low and 5 high affinity binding sites (15-17). A number of laboratories have reported only 5 binding sites per IgM pentamer (18-22). Some results of less than 10 binding sites may be attributed to steric hindrance of antigen binding and/or heterogeneity of IgM antibodies (20, 23, 24); however, other results appear free of this criticism, particularly those of Giles et al. (22) in which two monoclonal antidinitrophenyl (anti-DNP) IgM antibodies were shown to display an average of only 5 high affinity binding sites for DNP. Relevant to possible irregularities in IgM structure and valence, the present work provides evidence that some # chains of secreted IgM lack antigenic determinants characteristic of Igh variable regions (Igh-V). The truncated # (u') chains have an apparent molecular weight of ~55,000, display antigenic determinants in common with the u constant region (C/~), and are detectable in preparations of specifically purified IgM of different IgM-producing tumors and of normal serum IgM (a brief account of these findings was reported earlier [25]). u' Chains are also detectable in IgM-producing tumor cells, in a hybridoma cell line that lacks a productive # allele, and in bone marrow cells of normal mice. The possible significance of #' chains is discussed.
VARIATIONS IN PHYSIOCHEMICAL PROPERTIES OF INFUSION EXTRACTS OF COMMERCIALLY AVAILABLE TEA BAG SAMPLES

The study aimed to determine physiochemical properties (pH, conductivity, TDS and specific gravity) of extracts of various samples of tea (green and black) after their immersion for 5 and 10 minutes in hot water. The time of immersion showed remarkable effects on all studied parameters. In this perspective, the pH exhibited the inverse relation with brewing time while the other parameters showed direct relation with the brewing time. Black tea was found to be more acidic than green tea. Flavor of green tea also influenced the physiochemical properties especially pH/acidity i.e. Lemon flavored green tea has the lowest pH, highest acidity while, Elaichi (Cardamon) flavored green tea had the highest pH, lowest acidity.
COPD_A_247377 1245..1252

Hanan Tanash Magnus Ekström 2 Nawfal Basil Eva Rönmark Anne Lindberg Eeva Piitulainen 1Departments of Respiratory Medicine, Skåne University Hospital, Lund University, Lund, Sweden; 2Faculty of Medicine, Department of Clinical Sciences Lund, Respiratory Medicine and Allergology, Lund University, Lund, Sweden; 3Department of Public Health and Clinical Medicine, The OLIN Unit, Division of Occupational and Environmental Medicine, Umeå University, Umeå, Sweden; 4Department of Public Health and Clinical Medicine, Division of Medicine, Umeå University, Umeå, Sweden Background: Severe alpha-1-antitrypsin deficiency (AATD) is an established risk factor for chronic obstructive pulmonary disease (COPD) and liver disease, but the effect on the incidence of ischemic heart disease (IHD) is not well known. The aim was to evaluate the risk of incident IHD in patients with severe AATD compared with a random sample of the general population, with known smoking habits. Methods: AAT-deficient individuals, phenotype PiZZ (n=1545), were included in the Swedish National AATD Register. Controls (n=5883) were selected from population-based cohorts in Northern Sweden. Data on IHD and comorbidities were obtained by nationwide cross-linkage with the Swedish National Patient Register. Risk factors for incident IHD were analyzed using Cox regression, adjusted for age, gender, smoking status and the presence of COPD, hypertension, hyperlipidemia and diabetes. Results: At inclusion, 46% of the PiZZ individuals and 53% of the controls were neversmokers. During follow-up (median 16 years; range 0.2–23), 8% (n=123) of PiZZ individuals and 12% (n=690) of controls developed IHD. The controls had a significantly higher risk for incident IHD than the PiZZ individuals, with adjusted hazard ratio (HR) of 1.8 (95% CI 1.4–2.3). The risk was higher for controls in both ever-smokers (HR 2.1; 95% CI 1.5–2.9) and never-smokers (HR 1.5; 95% CI 1.1–2.2). Conclusion: PiZZ individuals have a lower risk of developing incident ischemic heart disease than the control subjects with known smoking habits, who had been randomly selected from population-based cohorts.
Measuring starspot temperature from line depth ratios (cid:63) I. The method

Gray and collaborators have recently demonstrated that line-depth ratios are a powerful tool for temperature discrim-ination, able to resolve di ﬀ erences (cid:20) 10 K. The method has been applied to detect temperature variations in the 5–15 K range due to activity cycles (e.g. Gray et al. 1996a, 1996b) or to rotation modulation produced by large surface features, called “star-patches”, like that detected in (cid:24) Boo A by Toner & Gray (1988). Cool starspots of a few tenths of the stellar surface produce bumps in a line proﬁle, which migrate through the line proﬁle allowing Doppler-imaging in fast rotating stars. In the hypothesis that in slowly-rotating stars the passage of dark spots produces modulation of the center line depth of di ﬀ erent amount in lines of di ﬀ erent sensitivity to temperature, we have made test observations on three active binaries of the RS CVn type. Based on observations made at the Catania Astrophysical Observatory at a resolution R = 14 000, we show that line-depth ratios can be e ﬀ ectively used to determine spot temperatures of active binary systems. Using, on average, ten line pairs, selected in the 6100–6300 Å wavelength range, with the help of observations of 30 main sequence and giant stars, we have derived a calibration relation of line-depth ratios (LDR) in an absolute temperature scale, taking into account the gravity e ﬀ ect in the calibration relation. Single LDRs converted to temperature through the calibration relations have led to clear rotational modulation of the average surface temperature with amplitudes of 177 K, 119 K, and 127 K for VY Ari, IM Peg and HK Lac, with average estimated errors of about 10 K. We show that the observed temperature variation amplitude allows us to deﬁne a minimum fractional spotted area coverage as a function of spot-photosphere temperature ratio. Adopting the maximum value of average temperature, determined from the LDRs, as that of the unspotted photosphere, we computed the average spot temperature corresponding to the minimum spot coverage. Although not univocally constrained, the temperature di ﬀ erence ( ∆ T = T ph − T sp ) obtained for the three systems, ∆ T = 890 K for VY Ari, ∆ T = 750 K for IM Peg, and ∆ T = 810 K for HK Lac, are in good agreement with values derived with other methods.
Exploitation and Benefits of BIM in Construction Project Management

BIM is increasingly getting into the awareness in construction industry. BIM is the process of creating and data managing of the building during its life cycle. BIM became a part of management tools in modern construction companies. Construction projects have a number of participants. It means difficulty process of construction project management and a serious requirement for processing the huge amount of information including design, construction, time and cost parameters, economic efficiency and sustainability. Progressive information and communication technologies support cost management and management of construction project. One of them is Building Information Modelling. Aim of the paper is to examine the impact of BIM exploitation and benefits on construction project management in Slovak companies.
LYMPHOID NEOPLASIA Gene expression signatures delineate biological and prognostic subgroups in peripheral T-cell lymphoma

Gene expression signatures delineate biological and prognostic subgroups in peripheral T-cell lymphoma Javeed Iqbal, George Wright, Chao Wang, Andreas Rosenwald, Randy D. Gascoyne, Dennis D. Weisenburger, Timothy C. Greiner, Lynette Smith, Shuangping Guo, Ryan A. Wilcox, Bin Tean Teh, Soon Thye Lim, Soon Yong Tan, Lisa M. Rimsza, Elaine S. Jaffe, Elias Campo, Antonio Martinez, Jan Delabie, Rita M. Braziel, James R. Cook, Raymond R. Tubbs, German Ott, Eva Geissinger, Philippe Gaulard, Pier Paolo Piccaluga, Stefano A. Pileri, Wing Y. Au, Shigeo Nakamura, Masao Seto, Francoise Berger, Laurence de Leval, Joseph M. Connors, James Armitage, Julie Vose, Wing C. Chan, and Louis M. Staudt, for the Lymphoma Leukemia Molecular Profiling Project and the International Peripheral T-cell Lymphoma Project
Antimicrobial resistance in

HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignement et de recherche français ou étrangers, des laboratoires publics ou privés. Antimicrobial resistance in Haihui Huang, Andrej Weintraub, Hong Fang, Carl Erik Nord
Inflation versus taxation

The trade-off between inflation and taxation is analysed in a model with heterogeneity in nominal debt holdings. This creates a political conflict among the electorate. As a benchmark we study a "comple[ely representative" democracy, where more inequality leads to higher equilibrium inflation. Extensions include a more realistic two-party nomination system and real money balances in the utility function. Special attention is drawn to the sources of multiple politico-economic equilibria. Finally, an explicit comparison with the capital-levy problem is made.
OP-BRAI120023 3495..3512

This article provides a neurobiological account of symptoms that have been called ‘hysterical’, ‘psychogenic’ or ‘medically unexplained’, which we will call functional motor and sensory symptoms. We use a neurobiologically informed model of hierarchical Bayesian inference in the brain to explain functional motor and sensory symptoms in terms of perception and action arising from inference based on prior beliefs and sensory information. This explanation exploits the key balance between prior beliefs and sensory evidence that is mediated by (body focused) attention, symptom expectations, physical and emotional experiences and beliefs about illness. Crucially, this furnishes an explanation at three different levels: (i) underlying neuromodulatory (synaptic) mechanisms; (ii) cognitive and experiential processes (attention and attribution of agency); and (iii) formal computations that underlie perceptual inference (representation of uncertainty or precision). Our explanation involves primary and secondary failures of inference; the primary failure is the (autonomous) emergence of a percept or belief that is held with undue certainty (precision) following top-down attentional modulation of synaptic gain. This belief can constitute a sensory percept (or its absence) or induce movement (or its absence). The secondary failure of inference is when the ensuing percept (and any somatosensory consequences) is falsely inferred to be a symptom to explain why its content was not predicted by the source of attentional modulation. This account accommodates several fundamental observations about functional motor and sensory symptoms, including: (i) their induction and maintenance by attention; (ii) their modification by expectation, prior experience and cultural beliefs and (iii) their involuntary and symptomatic nature.
Title: Does treatment alleviate lymphoedema symptoms? A cross-sectional study evaluating patient perspectives.

Most studies evaluating lymphoedema treatment effect focus on objective reductions in limb volume, with little attention given to subjective treatment outcomes. The objective of this work was to describe the range of lymphoedema symptoms experienced by patients and the importance of symptom improvement following treatment. The second aim was to explore lymphoedema treatment use and the effect of individual treatments on symptoms, from the patient’s perspective. Australian adults with lymphoedema (n=421) completed a self-administered questionnaire. Information was collected about patients’ symptoms, the importance of symptom improvement following treatment, as well as treatment types used and perceived effectiveness of each treatment. In addition to swelling, the vast majority of participants experienced heaviness and tightness in the affected region. Overall, symptoms of lymphoedema varied between individuals but the majority considered subjective symptom improvement to be an important outcome of treatment. The most commonly used treatments were compression garments, self-massage, prescribed exercises and manual lymph drainage, and the majority (95%) of participants had used multiple treatments to manage their lymphoedema. The impact of treatments on subjective symptoms varies widely between treatments. Consequently, in addition to objective measures of swelling, it is important to include patient-reported outcomes in future prospective lymphoedema treatment studies.
NDT_A_334027 3345..3357

1Adult Psychiatry Division, Department of Psychiatry, Geneva University Hospitals (HUG), Geneva, 1225, Switzerland; 2Faculty of Medicine, University of Geneva, Geneva, 1204, Switzerland Abstract: Schizophrenia is a complex disease whose pathophysiology is not yet fully understood. In addition to the long prevailing dopaminergic hypothesis, the evidence suggests that neuroinflammation plays a role in the pathophysiology of the disease. Recent studies using positron emission tomography (PET) that target a 18kDa translocator protein (TSPO) in activated microglial cells in an attempt to measure neuroinflammation in patients have shown a decrease or a lack of an increase in TSPO binding. Many biological and methodological considerations have been formulated to explain these findings. Although dopamine has been described as an immunomodulatory molecule, its potential role in neuroinflammation has not been explored in the aforementioned studies. In this review, we discuss the interactions between dopamine and neuroinflammation in psychotic states. Dopamine may inhibit neuroinflammation in activated microglia. Proinflammatory molecules released from microglia may decrease dopaminergic transmission. This could potentially explain why the levels of neuroinflammation in the brain of patients with schizophrenia seem to be unchanged or decreased compared to those in healthy subjects. However, most data are indirect and are derived from animal studies or from studies performed outside the field of schizophrenia. Further studies are needed to combine TSPO and dopamine imaging to study the association between microglial activation and dopamine system function.
CONCEPTUAL METAPHOR WITHIN INVARIANT MEANING: THE LEARNING OF PHRASAL VERBS AMONG MALAYSIAN ESL LEARNERS

This study intends to determine the invariant/core meanings of verbs and particles in isolation and see how these meanings motivate the distribution of messages in English phrasal verbs. It also aims to see if the exposure to the core meanings of the individual items that make up a phrasal verb (i.e. verb and particle) helps Malaysian learners to use phrasal verbs appropriately in English writings. The linguistic data were extracted from the BNC corpus. Tobin (1990)’s concept of invariant meaning and Lakoff & Johnson (1980)’s notion of Conceptual Metaphor were used to determine the core meanings of the verbs and particles. The analyses showed that the identification of single invariant meaning of the verbs and particles is important as they contribute to the realisation of different senses of phrasal verbs. These invariant meanings were then applied as treatment with fifteen students in the experimental group whereas another group of fifteen students which was assigned as the control group was engaged into traditional instruction by providing the meanings of the phrasal verbs extracted from the Oxford Phrasal Verbs Dictionary. The inferential analyses through paired samples t-test and independent samples t-test for the taught items indicate that although both groups performed significantly better in post-tests compared to pre-tests, the experimental group which received the semantic-based explicit (verbs and particles in phrasal verbs) instruction outperformed (significantly) the control group which received traditional instruction.
Microbiological ndings in early and late implant loss: an observational clinical cohort study

Michael Korsch (  mk@drkorsch-heidelberg.de ) Dental Academy for Continuing Professional Development https://orcid.org/0000-0001-8841-2744 Christopher Prechtl Center for Implantology an Oral Surgery Heidelberg Silke-Mareike Marten Karlsruher Institut fur Technologie Dominic Stoll Max Rubner-Institut Bundesforschungsinstitut fur Ernahrung und Lebensmittel Andreas Dötsch Karlsruher Institut fur Technologie