Miracle-dz/UniFAR-FTUs huggingface dataset:
miR-486-5p and miR-22-3p Enable Megakaryocytic Differentiation of Hematopoietic Stem and Progenitor Cells without Thrombopoietin

Megakaryocytes release submicron size microparticles (MkMPs) in circulation. We have shown that MkMPs target CD34+ hematopoietic stem/progenitor cells (HSPCs) to induce megakaryocytic differentiation, and that small RNAs in MkMPs play an important role in the development of this phenotype. Here, using single-molecule real-time (SMRT) RNA sequencing (RNAseq), we identify the synergetic effect of two microRNAs (miRs), miR-486-5p and miR-22-3p (highly enriched in MkMPs), in driving the Mk differentiation of HSPCs in the absence of thrombopoietin (TPO). Separately, our data suggest that the MkMP-induced Mk differentiation of HSPCs is enabled through JNK and PI3K/Akt/mTOR signaling. The interaction between the two signaling pathways is likely mediated by a direct target of miR-486-5p and a negative regulator of PI3K/Akt signaling, the phosphatase and tensin homologue (PTEN) protein. Our data provide a possible mechanistic explanation of the biological effect of MkMPs in inducing megakaryocytic differentiation of HSPCs, a phenotype of potential physiological significance in stress megakaryopoiesis.
Institutional Knowledge at Singapore Management University Mutual Fund Size, Fund Family Size and Mutual Fund Performance: The Role of Regulatory Changes

We examine whether the previously documented positive association between fund family size and fund performance is affected by significant regulatory changes (i.e., Regulation FD, the Global Settlement (GS), and increased scrutiny as a result of trading scandals) that have occurred in the last decade. Using Regulation Fair Disclosure (Reg FD) as a beginning point for these structural changes, we find that while fund family size was positively associated with fund performance in the period prior to the regulatory changes, this advantage is significantly weaker in the period subsequent to the regulatory changes. Consistent with the weakened advantage of fund family size in fund performance, we find that the greater stock picking skill of larger fund families, measured using the earnings announcement returns of the stocks they trade, also weakened subsequent to the regulatory changes. Using narrower event windows around the regulatory changes, we find that the previously documented superior return of large fund families was partly attributable to selective disclosure. We also find that fund families implicated in the trading scandals experienced a decline in their performance during the scandal period. Finally, we examine the role of large investment banks in providing an advantage to large fund families. Family size was positively associated with the extent to which funds traded in the same direction as forecast revisions by analysts from large investment banks in the period prior to Reg FD and the GS and this association declined significantly after the two regulatory events.
Validation of Repetitive Volcanoseismic Signals in Aso Volcano, Japan With Distant Stations: Implications of Source Characterization and Remote Sensing in Uninstrumented Volcanoes

Repetitive volcanoseismic signals, including very‐long‐period signals (VLP) and long‐period signals (LP), provide a unique probe of fluid transport processes inside magmatic‐plumbing system. While syneruptive signals are often detected and analyzed with regional or/and global seismic networks to retrieve eruption location and mechanism, repetitive noneruptive volcanoseismic signals are generally small, and they are typically detected with in situ stations near the volcanic edifices. Here, we show that repetitive VLP and synchronous deformation events in Aso volcano, Japan, can be detected in the high (15–30 s) and low (50–100 s) VLP bands, respectively, at seismic stations located ∼30–1,000 km away from their sources. Changes in the polarities, phases, and amplitudes of VLP and synchronous deformation events observed at the in situ stations can be verified by the seismic waves in the two VLP bands, respectively, at distant stations up to 150 km. Forward modeling of the amplitude decay in the two VLP bands against epicentral distance corroborates the source locations previously determined by the in situ data, whereas the joint data analysis of in situ and distant stations at high VLP band suggests the presence of single‐force component (i.e., force/moment ratio of 10−4 m−1) in the source of VLPs. We advocate that not only can systematic data mining against established global and regional seismic networks potentially expand the detection capability of repetitive volcanoseismic signals backward in time when in situ observations were unavailable, but it could also substantially improve the detection and monitoring capacity in otherwise uninstrumented volcanoes, complementary to remote sensing of ground deformation.
Comparative evaluation of severity of COVID-19 pneumonia on computed tomography of the chest in vaccinated and non-vaccinated individuals: an observational study

Purpose Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel virus causing an infectious disease, coronavirus disease 2019 (COVID-19). Computed tomography (CT) of the chest plays a significant role in the diagnosis and prognosis of COVID-19 using computed tomography severity scoring (CT-SS). Numerous vaccines are being made available in the world to lessen the effect of the COVID-19 pandemic. The purpose of the current study is to compare the severity of COVID-19 pneumonia using CT-SS in COVID-19-positive vaccinated (Covishield/Oxford-AstraZeneca) and non-vaccinated individuals and to compare the final outcome wherever possible. Material and methods This observational study was carried out from March 2021 to April 2021. Forty vaccinated and 40 non-vaccinated RT-PCR-positive COVID-19 patients who underwent CT chest during the 4-12th day of illness formed the material of the study. Semi-quantitative scoring was used, and CT-SS was calculated based on the extent of lobar involvement in all the patients. CT-SS was then compared between the vaccinated and non-vaccinated groups and the results analysed. Results CT scans were performed in 80 patients (40 patients each in the vaccinated and non-vaccinated groups). The majority of patients in the vaccinated group had mild (42.5%) and moderate (37.5%) CT-SS while the majority of patients in the non-vaccinated group had moderate (52.5%) and severe (27.5%) CT-SS score on chest CT. Also, no mortality was observed in the vaccinated group, with 2 deaths in the non-vaccinated group. Conclusions Covishield vaccine administration reduces the severity of COVID-19 pneumonia as compared to the nonvaccinated group, with a marked reduction in mortality.
Comparative therapeutic efficacy of imidocarb and diminazene aceturate against Babesia gibsoni in dogs

The present study estimated the therapeutic management of Babesia gibsoni in the dog population located in and around Jabalpur (M.P.). A total of 2103 dogs that were brought to Veterinary Clinical Complex, College of Veterinary Science & A.H. , Jabalpur and different government and private clinics of Jabalpur (M.P.) were screened for a period of six months (June 2021 to November 2021). 503 dogs found suspected based on clinical history viz . anorexia, fever, vomiting, diarrhoea, bleeding from the nostrils, pale of the mucous membrane, maelena, anaemia, jaundice, weight loss etc. and detection of the organisms in the blood of infected dogs and out of which 76 samples were haemoprotozoan positive amongst which 26 were B. gibsoni positive. For the therapeutic study, a total of 12 dogs confirmed for B. gibsoni were divided randomly into two treatment groups i.e., T2 and T3, each comprising of 6 dogs. Dogs of group T2 and T3 were treated with Doxycycline @ 5mg/kg bodyweight, PO, q12 h for 30 days +Metronidazole @ 15 mg/kg bodyweight, PO, q12 h for 30 days +Imidocarb @ 6.6 mg/kg bodyweight, S/C, two doses14 days apart and Doxycycline @ 5mg/kg bodyweight, PO, q12 h for 30 days +Metronidazole @ 15 mg/kg bodyweight, PO, q12 h for 30 days + Diminazene aceturate @ 5 mg/kg bodyweight, I/M, two doses 48 h apart respectively. The best therapeutic response was observed in the T2 group. A blood smear examination reveals a lower the degree of Parasitemia on the 15 th -day post-treatment and on the 30 th -day post-treatment blood smear was negative in all affected dogs.
Zinc oxide, lidocaine, and lateral internal sphincterotomy for fissure-in-ano: a comparative study

Background: The aim of the study was to choose best method for management of fissure-in-ano. By comparing among zinc oxide pomade, lidocaine pomade and lateral internal sphincterotomy for treatment of anal fissure.Methods: 90 patients who were diagnosed with anal fissure between 2019 and 2021 at our MGM Medical College and M. Y. Hospital were undertaken for this prospective randomized trial. All cases randomized into three groups. Group 1 were the patients who applied 15% of zinc oxide pomade twice a day. Group 2 were the patients would apply 5% of lidocaine pomade twice a day. Group 3 were those undergone with lateral internal sphincterotomy. Healing rates, pain relief, recurrences, changes in symptoms after the treatment and complications were recorded.Results: There were no statistical difference among groups in terms of age and gender. The healing and symptomatic relief in the sphincterotomy group significantly much more when compared to the other groups (p=0.05). Recurrence rate is very less in sphincterotomy group. Conclusions: Lateral internal sphincterotomy is better treatment option when compared to zinc oxide and lidocaine. There was no difference between zinc oxide and lidocaine treatments.
The blind spots of measuring online news exposure: a comparison of self-reported and observational data in nine countries

ABSTRACT Measures of news exposure are common in research that tries to explain political knowledge, political engagement, opinion formation and, more generally, media effects. Much of that research employs self-reported measures obtained with surveys, known to suffer from accuracy problems. Observational measures, however, also suffer from limitations derived from data collection and instrumentation. Here we offer new comparative evidence on the nature of those problems. We show that commonly used self-report measures of digital news consumption are problematic for three reasons: they only pay attention to a small fraction of all available sources; they underestimate audience share; and they distort the relative position of news sites in visibility rankings. Measurement problems, however, also exist in observational studies, especially when mobile access is excluded from data collection. Our analyses quantify the magnitude of these problems, offering unprecedented comparative evidence of online news consumption that spans nine countries and a period of five years. We discuss the implications of our findings for future research on news exposure.
The Comparison of Appraisal Resources in Argumentative Essays Written by Students with Different Proficiency Levels

This study aimed to explain the appraisal resources manifested in argumentative essays written by undergraduate students with high and low proficiency level, as well as their similarities and differences of using appraisal resources. This study employed qualitative research in the form of written discourse analysis. The appraisal resources checklist adapted from Martin and White (2005) is used to determine the distribution of appraising items of attitude, engagement and graduation in argumentative essays written by high and low proficiency students. Out of 16 students chosen as the sample, 8 students are categorized as having high proficiency level, and the others eight belong to low proficiency level. The results of this study revealed that both groups of students utilized all subsystem of appraisal resources. However, high proficiency students dominantly used engagement rather than attitude and graduation. Meanwhile, the lows one utilized more attitude than engagement and graduation. In term of attitude, high proficiency students produced more appreciation. It showed that the argumentative essays written by high proficiency students are more appreciative than emotional and judgmental to align their personal voices in conveying their thoughts and opinions. In addition, in term of engagement, both groups dominantly applied entertain item in which it showed that both groups of students are successful to show their authorial voice towards the topic given. Finally, in graduation feature, force is dominantly used by both groups of students which means that they tried to intensify and quantify their arguments to build strong persuasion.
The Impact of COPD on Hospitalized Patients with Diabetes: A Propensity Score Matched Analysis on Discharge Records

(1) Background: Type 2 diabetes is a common comorbidity of chronic obstructive pulmonary disease. Despite the lack of knowledge of the pathophysiological link between diabetes and chronic obstructive pulmonary disease, the presence of diabetes among those with chronic obstructive pulmonary disease is associated with worse outcomes, such as mortality and hospitalization. The aim of this study was to evaluate the impact of chronic obstructive pulmonary disease on in-hospital mortality and prolonged length of stay (PLOS) among patients with diabetes. (2) Methods: The study considered all hospital admissions of patients with diabetes aged over 65 years performed from 2006 to 2015 in Abruzzo, Italy. To compare outcomes between patients with and without chronic obstructive pulmonary disease, a propensity score matching procedure was performed. (3) Results: During the study period, 140,556 admissions of patients with diabetes were performed. After matching, 18,379 patients with chronic obstructive pulmonary disease and 18,379 controls were included in the analyses. Logistic regression analyses showed as chronic obstructive pulmonary disease was associated with in-hospital mortality (OR: 1.10; p = 0.036) and PLOS (OR: 1.18; p = 0.002). (4) Conclusions: In a cohort of Italian patients, diabetic patients with chronic obstructive pulmonary disease were associated with in-hospital mortality and PLOS. The definition of the causes of these differences aims to implement public health surveillance and policies.
Does Geographic Location Affect the Quality of Care? The Difference in Readmission Rates Between the Border and Non-Border Hospitals in Texas

Purpose Previous literature has limited empirical evidence describing the association between border location and readmission rates among hospitals in the U.S.-Mexico border region. Thus, our study explores this novel connection in Texas border hospitals using a non-experimental longitudinal study design. Materials and Methods Using longitudinal panel data (2013~2016) drawn from the American Hospital Association Annual Survey Database, Hospital Compare, and Area Health Resource File, a random-effects linear regression analysis was performed to quantify the impact of border location on the readmission rates of the same sample at multiple timed points. Results We found a positive relationship between border location and 30-day hospital readmission rates for heart failure and pneumonia in Texas. Border hospitals in Texas had approximately a 4.17% higher heart failure readmission rate and a 3.46% higher pneumonia readmission rate than non-border hospitals. We also identified several hospital organizational and market factors associated (eg, registered nurse [RN]-to-patient ratio) with hospital readmission rates. Conclusion The results suggest that improving RN staffing levels can be the most feasible action to lower the readmission rates among border Texas hospitals. Decreasing readmission rates by increasing RN staffing levels would also help them avoid reimbursement reduction under the Hospital Readmission Reduction Program (HRRP) and enhance overall health in Texas border communities. Further, to improve border health in Texas, decision-makers in state and local governments must consider incentivizing border hospitals to improve RN staffing levels and modulating the market factors affecting hospital readmission rates that are mostly beyond the control of hospitals.
Highly Scalable Raised Source/Drain InAs Quantum Well MOSFETs Exhibiting I ON = 482 μA/μm at I OFF = 100 nA/μ ma ndV DD = 0. 5V

We report raised source/drain (S/D) InAs quantum well MOSFETs incorporating a vertical spacer formed by metal- organic chemical vapor deposition epitaxial regrowth. By adopt- ing a 12-nm-thick vertical spacer between the channel and the N+ S/D, OFF-state characteristics are significantly improved. A device with a 40-nm-L g and 12-nm-thick spacer shows 2.5-mS/µm peak transconductance (gm), 86-mV/decade sub- threshold swing at V DS = 0.5 V, 83-mV/V drain-induced barrier lowering, and 482-µA/µm ON-current at 100-nA/µm OFF-current and V DD = 0.5 V. In addition, a 3.0-mS/µ mp eak gm at V DS = 0.5 V is achieved in an 18-nm-L g device with a 2-nm-thick spacer, the highest reported peak gm of any field- effect transistor.
Responses Are Larger Than We Think during a Viral Infection: CD4 T Cell Quantifying Antigen-Specific CD4 T Cells

The number of virus-speciﬁc CD8 T cells increases substantially during an acute infection. Up to 90% of CD8 T cells are virus speciﬁc following lymphocytic choriomeningitis virus (LCMV) infection. In contrast, studies identifying virus-speciﬁc CD4 T cell epitopes have indicated that CD4 T cells often recognize a broader array of Ags than CD8 T cells, consequently making it difﬁcult to accurately quantify the total magnitude of pathogen-speciﬁc CD4 T cell responses. In this study, we show that CD4 T cells become CD11a hi CD49d + after LCMV infection and retain this expression pattern into memory. During the effector phase, all the LCMV-speciﬁc IFN- g + CD4 T cells display a CD11a hi CD49d + cell surface expression phenotype. In addition, only memory CD11a hi CD49d + CD4 T cells make IFN- g after stimulation. Furthermore, upon secondary LCMV challenge, only CD11a hi CD49d + memory CD4 T cells from LCMV-immune mice undergo proliferative expansion, demonstrating that CD11a hi CD49d + CD4 T cells are truly Ag speciﬁc. Using the combination of CD11a and CD49d, we demonstrate that up to 50% of the CD4 T cells are virus speciﬁc during the peak of the LCMV response. Our results indicate that the magnitude of the virus-speciﬁc CD4 T cell response is much greater than previously recognized. The Journal of Immunology , 2011, 187: 000–000. and CD29, respec-tively) and a L b 2 (CD11a and CD18, respectively) that mediate their migration to the site of infection (8, 9). Therefore, given the important role of integrins in the migration of effector CD4 T cells, we sought to determine whether modulation of these trafﬁcking molecules would provide a reliable cell surface phenotypic proﬁle to identify Ag-speciﬁc CD4 T cells after viral in-fection.Inthis study, we demonstrate that LCMV-speciﬁc CD4 T cells increase cell surface expression of CD11a and induce expression of CD49d following infection and that expression of these molecules remains stable into memory. We show that, whereas naive CD4 T cells are CD11a lo CD49d 2 , LCMV-speciﬁc effector CD4 T cells identiﬁed by LCMV–peptide-driven IFN- g production are CD11a hi CD49d + . In addition, we demonstrate that only CD11a hi CD49d + CD4 T cells from LCMV-immune mice produce IFN- g after stimulation and that only CD11a hi CD49d + CD4 T cells from LCMV-immune mice respond after a secondary LCMV challenge. Our results demonstrate that the combination of CD11a and CD49d can be used to determine the magnitude of the Ag-speciﬁc CD4 T cell response following infection and that all LCMV-speciﬁc memory CD4 T cells are CD11a hi CD49d + . Importantly, we demonstrate that up to 50% of the CD4 T cells at the peak of the LCMV response are CD11a hi CD49d + , indicating that the magnitude of the Ag-speciﬁc CD4 T cell response following viral infection is much greater than previously recognized.
CoreBug: Improving Effort-Aware Bug Prediction in Software Systems Using Generalized k-Core Decomposition in Class Dependency Networks

: Complex network theory has been successfully introduced into the ﬁeld of software engineering. Many works in the literature have built complex networks in software, usually called software networks, to represent software structure. Such software networks and their related graph algorithms have been proved effective in predicting software bugs. However, the software networks used were unweighted and undirected, neglecting the strength and direction of the couplings. Worse still, they ignored many important types of couplings between classes, such as local variable , instantiates , and access . All of these greatly affect the accuracy of the software network in representing the topological detail of software projects and ultimately affect the metrics derived from it. In this work, an improved effort-aware bug prediction approach named CoreBug is proposed. First, CoreBug uses a weighted directed class dependency network (WDCDN) to precisely describe classes and their couplings, including nine coupling types and their different coupling strengths and directions. Second, a generalized k -core decomposition is introduced to compute the coreness of each class in the WDCDN. Third, CoreBug combines the coreness of each class with its relative risk , as returned by the logistic regression, to quantify the risk of a given class being buggy. Empirical results on eighteen Java projects show that CoreBug is superior to the state-of-the-art approaches according to the average ranking of the Friedman test.
Benign and Pathological Religious Experience Experiência religiosa benigna e patológica

In this paper, I draw on phenomenological analyses of religious voice-hearing and related experiences to elucidate the role of phenomenology in discerning benign from pathological religious experience. First, I present phenomenological discontinuities between cases of benign and pathological voice-hearing by drawing on a study of first-person accounts of voice-hearers within the Pentecostal movement which evinces that voice-hearing is not inherently pathological. Second, I introduce the epidemiological continuity of psychotic-like phenomena by drawing on a study of the contextual and responsive differences between clinical and non-clinical voice-hearers which point to the contexts wherein voice-hearing does not lead to pathology. Third, I present a successful case where the meaning of the anomalous experiences is validated and normalized by drawing on studies of mediumistic experience which illuminate its therapeutic benefits. Finally, I argue that failing to take the voice-hearer’s lived experience into account in the diagnostic moment can result in the pathologization of benign experiences.