Miracle-dz/UniFAR-FTUs huggingface dataset:
MIDDLE-AGED WOMEN

Benton, MJ, Kasper, MJ, Raab, SA, Waggener, GT, and Swan, PD. Short-term effects of resistance training frequency on body composition and strength in middle-aged women. J Strength Cond Res 25(11): 3142–3149, 2011—Although a dose– response relationship between resistance training frequency and strength has been identified, there is limited research regarding the association between frequency and body composition. This study evaluated the effects of 3 vs. 4 d wk of resistance training on body composition and strength in middle-aged women. Twenty-one untrained women (age 47.6 6 1.2 years) completed 8 weeks of resistance training either 3 nonconsecutive days of the week using a traditional total-body protocol (RT3) or 4 consecutive days of the week using an alternating split-training protocol (RT4). The RT3 completed 3 sets of 8 exercises, whereas RT4 completed 3 sets of 6 upper body exercises or 6 sets of 3 lower body exercises. Both groups completed 72 sets per week of 8–12 repetitions at 50–80% 1 repetition maximum. Weekly training volume load was calculated as the total number of repetitions 3 load (kg) completed per week. Body composition was measured using air displacement plethysmography. At baseline and after 8 weeks of resistance training, there were no significant between-group differences. Both protocols resulted in significant increases in absolute lean mass (1.1 6 0.3 kg; p = 0.001), body weight (1.02 6 0.3 kg; p = 0.005), body mass index (0.3 6 0.1 kg m; p = 0.006), strength (p , 0.001), and weekly training volume load (p , 0.001). Correlation analysis revealed that weekly training volume load was strongly and positively related to gains in lean mass (r = 0.56, p = 0.05) and strength (r = 0.60, p = 0.006). In these untrained, middle-aged women, initial short-term gains in lean mass and strength were not influenced by training frequency when the number of training sets per
Sports Med 2007; 37 (3): 225-264

226 1. Methods . 227 1.1 Literature Search . 227 1.2 Classification of Muscle Actions, Training Methods and Modalities . 228 1.3 Quantification of Exercise Frequency, Intensity and Volume . 229 1.4 Classification of Training Status . 230 1.5 Calculation of Changes and Rate of Changes in Muscle Cross-Sectional Area (CSA) . 230 2. Results Part 1: Quadriceps Studies . 231 2.1 Quadriceps Studies: Dynamic External Resistance . 231 2.1.1 Length of Training Period, Average Increase in CSA and CSA Per Day . 232 2.1.2 Rate of Gain in CSA: Men versus Women . 232 2.1.3 Frequency . 232 2.1.4 Intensity . 232 2.1.5 Volume . 232 2.2 Quadriceps Studies: Accommodating Resistance . 233 2.2.1 Length of Training Period, Average Increase in CSA and CSA Per Day . 233 2.2.2 Frequency . 233 2.2.3 Velocity . 234 2.2.4 Torque . 234 2.2.5 Volume . 234 2.2.6 Total Duration Per Session . 235 2.2. 7 Time-Torque Product Per Session . 235 2.3 Quadriceps Studies: Isometric Resistance. 235 2.3. 1 Length of Training Period, Average Increase in CSA and CSA Per Day . 235 2.3. 2 Frequency . 235 2.3. 3 Intensity . 235 2.3. 4 Volume . 235 2.4 Quadriceps Studies: Combined Strength and Endurance Training . 236 2.4. 1 Rate of Gain in CSA: Combined Training versus Pure Strength Training . 236 2.4. 2 Length of Training Period and Increase in CSA . 236 2.5 Quadriceps Studies: All Voluntary Training Modes . 236 2.5. 1 Length of Training Period and Increase in CSA . 236 2.6 Quadriceps Studies: Strength Training as a Countermeasure During Unloading . 236
Effects of concentric and eccentric contractions on phosphorylation of MAPK and MAPK in isolated rat skeletal muscle

ubiquitous signalling proteins involved in control of cell growth, differentiation and adaptation (Fanger, 1999; Tibbles & Woodgett, 1999). Four parallel cascades of MAPKs have recently been described in mammalian cells, i.e. extracellular signal-regulated kinase 1 and 2 (MAPK), stress-activated protein kinase p38 (MAPK), c-jun NH2-terminal kinase (MAPK ), and extracellular signal-regulated kinase 5 (MAPK) (for review see Widmann et al. 1999). MAPKs are activated via dual phosphorylation on threonine and tyrosine residues by MAPK kinases (Widmann et al. 1999). Factors that have been shown to trigger MAPK activation include hormones, growth factors, reactive oxygen species (ROS), lowered pH and mechanical stress (Guyton et al. 1996; Xue & Lucocq, 1997; Williams et al. 1998; Loufrani et al. 1999). Following activation, MAPKs can either phosphorylate different cytoplasmic targets or translocate to the nucleus and directly or indirectly affect transcription. Transcription factors such as Elk1, ATF2, AP1, CREB and MEF2C have been reported to be downstream of MAPKs (Widmann et al. 1999; Zetser et al. 1999). In addition, signals conducted via MAPK and MAPK may facilitate the initiation of translation via phosphorylation of Mnk1 kinase, which activates the eukaryotic translation initiation factor 4E (eIF4E), the limiting initiation factor in most cells (for review see Raught & Gingras, 1999).
Knowledge Management Maturity in Universities and its Impact on Performance Excellence "Comparative study"

The paper assesses Knowledge Management Maturity (KMM) in the universities to determine the impact of knowledge management on performance excellence. This study was applied on Al-Azhar University and Al-Quds Open University in Gaza strip, Palestine. This paper depends on Asian productivity organization model that used to assess KMM. Second dimension which assess performance excellence was developed by the authors. The controlled sample was (610). Several statistical tools were used for data analysis and hypotheses testing, including reliability Correlation using Cronbach’s alpha, “ANOVA”, Simple Linear Regression and Step Wise Regression. The overall findings of the current study suggest that KMM is suitable for measuring performance excellence. KMM assessment shows that both universities maturity level is in level three. Findings also support the main hypothesis and it is subhypotheses. The most important factors effecting performance excellence are: Processes, KM leadership, People, KM Outcomes. Furthermore the current study is unique by the virtue of its nature, scope and way of implied investigation, as it is the first comparative study in the universities of Palestine explores the status of KMM using the Asian productivity Model.
Prognostic value of serum MMP-9 level in acute ischemic stroke patient

Purpose: MMP-9 is reported to be a marker of severity and worse outcome after stroke. Despite the above information, there are very few studies based on the evaluation of role of follow-up estimation of serum MMP-9 in acute ischemic stroke (AIS) patients. The purpose of this study was to evaluate the role of follow-up estimation of serum MMP-9 in the prognosis of AIS patients. MMP-9 levels were also compared with reported biomarkers viz. Neuron-Specific Enolase (NSE), Glial specific protein (S100{beta}{beta}) and Inter--trypsin inhibitor heavy chain 4 (ITIH4). Materials/methods: MMP-9, NSE, and S-100{beta}{beta} were measured in serum samples collected at admission and expired/discharge time of AIS patients (n=48) using commercially available ELISA kits. ITIH4 was measured using Indirect ELISA protocol. Results: MMP-9 at admission (3639 {+/-}1471) and discharged/expired (3707 {+/-}1268) was significantly higher (p<0.05) in AIS patients as compared to healthy control subjects (749 {+/-}302). Expired patients showed significantly (p<0.05) higher MMP-9 as compared to survivors. Similarly, follow-up MMP-9 at discharge was higher in AIS patients who expired within one year (75%; 3/4). The observed values of MMP-9 significantly correlates (p<0.05) with NSE (r=0.452), S-100{beta}{beta} (r=0.452) and ITIH4 (r=-0.2027). Conclusions: Follow-up measurement of serum MMP-9 may help to predict both short term and long term mortality in AIS patients. Keywords: Cerebrovascular disease; Ischemic Stroke; Matrix Metalloproteinases-9; ITIH4; Prognosis
Homologous and heterologous boosting of the ChAdOx1-S1-S COVID-19 vaccine with the SCB-2019 vaccine candidate: a randomized, observer-blinded, controlled, phase 2 study

Background: Ongoing outbreaks of COVID-19 have been associated with waning immunity following primary immunizations and emergence of new SARS-CoV-2 variants. Heterologous boosters have been suggested to maintain population immunity. Methods: In this study of heterologous boosters we assessed immunogenicity and reactogenicity of booster doses of different formulations of alum-adjuvanted SCB-2019 vaccine (9 g SCB-2019 with or without CpG-1018 adjuvant, or 30 g SCB-2019 with CpG-1018) in Brazilian adults primed with ChAdOx1-S vector vaccine. S-protein and ACE2 binding antibodies were measured by ELISA on Days 1, 15 and 29. Participants self-reported solicited adverse events and reactions. Results: All SCB-2019 formulations increased ELISA antibodies against S-protein and ACE2 to a greater extent than ChAdOx1-S. After 30 g SCB-2019+CpG+alum titers against wild-type S-protein and ACE2 were significantly higher than after ChAdOx1-S on Days 15 and 29, as were GMTs for neutralizing antibodies against wild-type strain and Beta, Gamma, Delta, and Omicron variants. Boosting with SCB-2019 or ChAdOx1-S was well tolerated with no vaccine-related serious or severe adverse events. Conclusions: Heterologous boosting with SCB-2019 of ChAdOx1-S-primed adults was more efficient in increasing immunity against wild-type strain and SARS-CoV-2 variants than a homologous ChAdOx1-S booster, highest responses being with the 30 g SCB-2019+CpG+alum formulation.
and Promoting Self Care Activities among Overweight and Obese Pre-Adolescents: A Randomized Controlled Trial

INTRODUCTION: Pediatric obesity has been considered as one of the most serious public health challenges in the world. AIM: T o reduce “Screen - time” and promoting self care activities among overweight and obese pre-adolescents (aged 10-12 years) in India through proper intervention measures. MATERIALS AND METHOD: Designed as a two-armed randomized controlled trial, 537 pre-adolescents aged 10-12 years were enrolled in this online study. Data was collected through a questionnaire (containing close-ended 26 questions). Pre- adolescents, whose BMI was classified as “overweight” and “obese” were enrolled and randomly assigned (flip of coin) to the intervention group and control group. The intervention group were then given monthly online one-on-one sessions (to maintain confidentiality) by five standardized instructors. The study lasted for four months and a total of four individual sessions were provided to each child in the intervention group. Data was transferred into Excel for descriptive statistics, and analysed using SPSS version 22.0 using the paired t-test and multi variate logistic regression was applied keeping the significance value of p as ≤ 0.05 RESULTS: A total of 537 pre- adolescents met the inclusion criteria. Among them, 270(50.3%) belonged to the intervention group and 267 (49.7%) belonged to the control group. Majority of the pre- adolescents were males (59.4%). In the intervention group, there were 61.8% overweight pre-adolescents, which reduced to 42.9%, while in the control group, there were 89.5% overweight pre-adolescents, which reduced 9.8% and the difference between both the groups was observed to be significant (p=0.02). CONCLUSION: Techniques used in the intervention group led to positive outcomes like weight loss and reduced screen time among the pre-adolescents which in turn, helped reduce the global burden of disease.
UNILATERAL RESISTANCE TRAINING

Coburn, J.W. , D.J. Housh, T.J. Housh, M.H. Malek, T.W. Beck, J.T. Cramer, G.O. Johnson, and P.E. Donlin. Effects of leucine and whey protein supplementation during eight weeks of unilateral resistance training. J. Strength Cond. Res. 20(2): 284–291. 2006. —The purpose of this study was to determine the effects of resistance training in combination with a leucine and whey protein supplement or a carbohydrate placebo on strength and muscle cross-sectional area (CSA). Thirty-three men (mean age 6 SD 5 22.4 6 2.4 years) were assigned to 1 of 3 groups: (1) supplementation group (SUPP), (2) placebo group (PL), or (3) control group (CON). The SUPP and PL performed unilateral training of the leg extensor muscles with the nondominant limb for 8 weeks. The strength of each limb, muscle CSA of the quadriceps femoris (QF), and body composition were assessed pretraining and posttraining. The results indicated significant increases in strength for both limbs in the SUPP but only the trained limb in the PL. The increase in strength for the trained limb of the SUPP was greater than that for the trained limb of the PL. There was no significant increase in strength for either limb in the CON. There were significant increases in the CSA of all muscles of the QF of the trained limb for the SUPP and PL, and of the vastus lateralis of the untrained limb for the SUPP. The increases in QF CSA did not differ between the SUPP and PL. No significant CSA changes were found for either limb in the CON. There were no significant changes in body composition for the SUPP, PL, or CON. The current findings suggest that leucine and whey protein supplementation may provide an ergogenic effect which enhances the acquisition of strength beyond that achieved with resistance training and a carbohydrate placebo.
Running title: ANALYSIS OF HYDROMETEOROLOGICAL IMPACT IN THE NEB. Academy Section: EARTH SCIENCES

Various studies have identifi ed that between 2012 and 2017, Brazil’s semiarid region suffered severe drought. However, few studies have analyzed whether this drought also affected the eastern coastal region of Northeast Brazil (ENEB). Therefore, the objective of this work is to identify rainfall anomalies in these regions and verify the hydrometeorological impact on reservoirs in the 2012-2017 interval. For this purpose, we used precipitation data and atmospheric variables in the period from 1981 to 2017 to investigate the rainy season and associated dynamic patterns, as well as the consequences of these mechanisms on the variation of the water parameters of important reservoirs. The results indicated that rain events in the ENEB during 20122017 presented similar climatological behavior, without the characteristic of a drought event as observed in the semiarid region. The meteorological analyses showed that the combination of convergence with moisture over the Atlantic Ocean possibly favored greater frequency of shallow convective rainfall in ENEB, an important factor to explain the absence of generalized negative anomalies in the region. As a consequence, the reservoirs did not suffer from water collapse, unlike in the semiarid region.
Prevention of oral biofilm formation and degradation of biofilm by recombinant α -1,3- 3 glucanases from Streptomyces thermodiastaticus HF3-3

The genes encoding α -1,3-glucanases (Agls; AglST1 and AglST2) from Streptomyces 27 thermodiastaticus HF3-3 were cloned and were then expressed in Escherichia coli Rosetta-gami 28 B (DE3). We purified the resultant histidine (His)-tagged α -1,3-glucanases (recombinant 29 enzymes, rAglST1 and rAglST2). Both the recombinant enzymes were similar to the wild-type 30 enzymes. We examined the effects of rAglST1 and rAglST2 on the formation and degradation of 31 biofilms on glass plates with Streptococcus mutans NRBC 13955 by evaluating the biofilm 32 content (%), release of reducing sugar (mM), release of S. mutans (log CFU/mL), and the biofilm 33 structure using laser scanning microscopy (LSM). The results showed that after incubation for 16 34 h, rAglST1 and rAglST2 reduced the formation of biofilm to 52% and 49% of the control, 35 respectively. The result may reflect the fact that the concentration of the reducing sugar and the 36 number of S. mutans cells in the rAglATs-added medium were higher than in the control 37 medium. After an 8-h treatment with rAglST1 and rAglST2, biofilms decreased to less than 60% 38 of the control. The number of S. mutans cells in the reaction mixture gradually increased during 39 the incubation period. The enzymes can degrade the biofilms that were pre-formed on the glass 40 plate by more than 50% after a 30-min incubation in the presence of toothpaste ingredients (1% 41 w/v of sodium fluoride, benzethonium chloride, and sodium dodecyl sulfate) at 50°C. Our study showed that rAglST1 and rAglST2 have advantageous properties for dental care AglFH1, one of the isozymes of α -1,3-glucanases from Paenibacillus glycanilyticus FH11, and obtained same results, including a part of three-dimensional structure of AglFH1 The 3D structure obtained showed that the region located adjacent to catalytic domain one calcium ion. In the case of AglFH1, Glu-X-Glu, Ser-X-X-Ser, and Asp in the region have been shown to involve Ca 2+ binding. In the case of AglFH2, the isozyme of AglFH1, Asp- X-Asp, Ser-X-X-Lys, and Asp are found in the corresponding region. In the C-terminal region of AglST2, Asp 626 -Gly 627 -Asp 628 , Ser 683 -Ser 684 -Phe 685 -Ser 686 , and Asp 711 are present in the sequence (DDBJ Accession These results suggest that these amino acid residues might be involved in the formation Ca 2+ binding X-ray crystallographic underway.
PaH_Studia Sociologica_2_2018.indd

In this paper we adhere to the view that the boundaries between common couple or situational violence and criminal act in the sense of the legal definition of the domestic violence are not totally sharp. The key thesis of general theory of crime (Gottfredson, 2005) about the importance of self-control we can develop so that the reasonable selfcontrol can act as a protective factor on the side of the men as victims of intimate partner violence. Our question is whether the individual characteristics of both actors do not create specific composition (configuration), which operates in the form of conflicts, or may encourage the emergence of IPV. For good reasons, however, we think more about the mediation role of these self-control configurations. We can justify it by the assumption that higher self-control in the case of men can support the state in which the victim is overestimating his own potential and manifested even patronizing attitude towards the offender. Our 5 item typology reconstructed for a representative sample of Czech men (N = 1001) demonstrates some special effects of asymmetric configurations. On the other side the calamity configuration based on the lack of self-control on both sides appears still as the most risky. The level of victimization of men seems to be similar if compared to women and their chance to solve the problem is limited due to some specific reasons which are discussed as well.
Effect of CO2 and N2 Composition in Modified Atmosphere Packaging (MAP) on Quality

19 The current study investigated the effects of the most suitable modified atmosphere packaging 20 (MAP) on the physicochemical, microbiological, and sensory properties of fermented dry sausages 21 during 45 days of refrigeration (4oC) storage period. Treatments were vacuum-packed (control), 22 25%CO2/75%N2 (MAP1), 50%CO2/50%N2 (MAP2), 70%CO2/30%N2 (MAP3) and 100% CO2 23 (MAP4). All MAP samples regardless of their CO2 composition significantly (p<0.05) decreased 24 in pH, aw, total plate count (TPC), and LAB count values as compared to the vacuum-package 25 during storage. The Enterobacteriaceae count in all MAP packaging was significantly (p<0.05) 26 lower than the vacuum-packed samples and counts in MAP3 and MAP4 samples were markedly 27 (p < 0.05) lower than all other treatments in prolonged storage of 15 and 45 days. Based on the 28 TBARS content at day 15 and 30 storage time, treatments are ranked as follows: vacuum-packed 29 >MAP1 >MAP2 >MAP3>MAP4. The a* value of MAP4 was higher than all other treatments. 30 In the final storage days, no variation was exhibited (p>0.05) among treatments in lactic acid aroma 31 and sourness, and MAP2 samples had the lowest (p<0.05) overall acceptability. The use of MAPs 32 with an increase in the CO2 from MAP1 to MAP4 samples can help in better microbial inhibition 33 than vacuum package, and 70%CO2/30%N2 (MAP3) and 100% CO2 (MAP4) were effective to 34 maintain several quality parameters (aw, pH, microbial inhibition, stability against lipid oxidation, 35 and instrumental color traits) and extend the shelf life of dry fermented sausage. 36
AODVMO: A S ECURITY R OUTING P ROTOCOL U SING O NE -T IME P ASSWORD A UTHENTICATION M ECHANISM BASED ON M OBILE A GENT

Ad hoc On-demand Distance Vector (AODV) routing protocols is one of the most popular reactive protocol used for Mobile Ad hoc Network and is a target of many Denial-of-Service attack types. In this article, we propose a solution for Initialization and Providing the OTP based on Mobile Agent (IPOM). We also propose a Security Routing Protocol using One-Time Password Authentication Mechanism based on Mobile Agent (AODVMO) by extending the original AODV protocol and integrating IPOM solution. Analysis results confirm that AODVMO can prevent almost current routing protocol attack types, such as Blackhole / Sinkhole, Grayhole, Whirlwind, and Wormhole types. Using NS2, we evaluate the packet overhead for providing OTP, the security performance on random waypoint network topology under Blackhole attacks and the effect of security mechanism to the original protocol. Simulation results show that the proposed solution works well, the performance of AODVMO is good under Blackhole attacks, and slightly reduced when integrating the security mechanism in scenarios without attacks.
Atorvastatin enhances apoptotic effects of tamoxifen on melanoma cancer cells

AIM: Tamoxifen engages mitochondrial estrogen receptor beta as an antagonist, increases mitochondrial cytotoxicity and induces tumor cell death. Tamoxifen also engages plasma membrane estrogen receptor alpha as an agonist, while it is suggested that in some users its activation is put into action by mechanism of resistance to tamoxifen. Apoptotic inducers have been shown to promote tamoxifen-induced cell death, which might be of great importance in overcoming tamoxifen resistance. Considering the pleiotropic effects of statins, in the present study, we investigated the effects of atorvastatin on tamoxifen-induced intrinsic apoptotic pathway activity in melanoma cells. METHODS: Melanoma B16F10 cells were treated for 24 and 48 h with various concentrations of tamoxifen, atorvastatin and combination of tamoxifen + atorvastatin. Cells with no treatment were considered a control group, and the study was then followed by quantitative RT- PCR assay. Bax and cytochrome c gene expressions were calculated by ΔΔ ct method. RESULTS: Co-treatment of atorvastatin + tamoxifen could strongly enhance the expression of pro/apoptotic factors of Bax and cytochrome c in melanoma cells compared to the tamoxifen and atorvastatin groups. CONCLUSION: In general, we conclude that the atorvastatin-induced increase in Bax and cytochrome c gene expression might be a permissive response to tamoxifen-induced cell death (Fig. 2, Ref. 37) . Text
EFFECT OF SPRINKLER RISER CHARACTERISTICS ON APPLICATION UNIFORMITY

The sprinkler riser characteristics; height, angle and rigid fixation are of great importance for the sprinkler application uniformity. Single sprinkler pattern tests were carried out to generate data required for field uniformities with different riser characteristics. Data from the single sprinkler tests were then overlapped to simulate system uniformities. Results were compared for different riser heights, riser angles, PVC and steel risers. Trials were carried out using two types of sprinkler heads. The statistical analysis indicated that riser characteristics affect significantly the application uniformity at 5 % significance level. However, the effect of some treatments was positive and for some others was negative. The negative effects of non-optimum riser characteristics can be minimized by closer spacing pattern.