Miracle-dz/UniFAR-FTUs huggingface dataset:
Reconstructive endovascular treatment for basilar artery trunk aneurysms: complications and clinical and angiography outcomes

Background Basilar artery trunk aneurysms (BTAs) are rare intracranial aneurysms. We aim to investigate the procedural complications and clinical and angiographic outcomes of BTAs treated with reconstructive endovascular treatment (EVT). Methods We retrospectively reviewed the data of 111 patients with BTAs who underwent reconstructive EVT during 2013–2022. The factors associated with procedural complications and clinical and angiographic outcomes were analyzed. Results The study included 81 men and 30 women (median age 60 years). Overall, 26 (23.4%) cases presented with subarachnoid hemorrhage and 85 (76.6%) presented with unruptured aneurysms. Periprocedural ischemic and hemorrhagic complications occurred in 29 (26.1%) and 4 (3.6%) cases, respectively. The rate of favorable clinical outcomes was 83.8% (92/111) and the mortality rate was 14.4% (16/111). Angiographic follow-up data were available for 77/95 (81.1%) survivors; 57 (74.0%) and 20 (26%) aneurysms exhibited complete and incomplete obliteration, respectively. Old age, high Hunt and Hess grades (IV–V), hemorrhagic complications, and increased aneurysm size were independent risk factors for unfavorable clinical outcomes (p<0.05). Increased aneurysm size and incomplete aneurysm occlusion on immediate angiography were independent risk factors for incomplete occlusion during follow-up (p<0.05). Conclusion Reconstructive EVTs are a feasible and effective treatment for BTAs but are associated with a high risk of ischemic and hemorrhagic complications and a high mortality rate. Larger aneurysms may predict unfavorable clinical outcomes and aneurysm recurrence during follow-up. Hemorrhagic complications may predict unfavorable clinical outcomes, whereas immediate complete aneurysm occlusion may predict total occlusion during follow-up.
Optimal ion acceleration from ultrathin foils irradiated by a profiled laser pulse of relativistic intensity

Recent investigations of relativistic laser plasmas have shown that the energy transfer from the laser field to the kinetic ion energy and therefore the attainable maximum energy of the ions increases when ultrathin targets are irradiated by laser pulse without prepulse. In this paper, the influence of the target thickness and laser pulse contrast on the energy of the accelerated ions has been studied theoretically as well as experimentally. An optimum target was searched if a real laser pulse with a certain prepulse irradiates the target.
The intervention of Brain Gym in the mathematical abilities of high-school students: A pilot study

Introduction The learning process of Mathematics is a challenge in Latin America; therefore, it is of vital importance to conduct actions that improve the performance in this science. Methods This article is reporting on quasi-experimental research, where, through the use of Brain Gym, the objective is to improve: the definition of rational numbers, problem-solving ability, mathematical order relationships, and equivalent fractions. We worked with 67 students between 12 and 14 years old, organized into an experimental group (n = 35) and a control group (no participation group; n = 32). Results We made pre and post-test measurements and found that the control group students improved in their problem-solving ability F(1,65) = 8.76, p = 0.04, η2 = 0.12 and equivalent fractions F(1,65) = 4.54, p = 0.03, η2 = 0.06. Discussion In conclusion, the importance of applying innovative processes to improve the teaching and learning of Mathematics can be affirmed. It is important to note that both the control and experimental groups improved their learning, however, the experimental group did so to a greater extent than the students in the control group, who received a traditional educational process, and they did learn, but not at the level of the experimental group.
The Career-Related Parental Involvement Scale: Development and Validation Among College Senior Emerging Adults in India and the U.S.

The senior year in college is a pivotal time for emerging adults as they plan and make career decisions for their post-college lives. During this challenging transition, parents may be a safeguard; however, little research identifies how parents are involved in their emerging adult’s career development. The present study examined career-related parental involvement (CRPI; for mothers and fathers separately) from the perspective of graduating seniors in India and the US to develop and validate a new CRPI scale. Participants (India n = 1544; US n = 247) completed the CRPI scale and other related measures. Findings suggest that the 20-item CRPI scale represents three dimensions of career involvement across cultures and parents: Support, Interference, and Disengagement. Results supported the scale’s convergent and concurrent validity (e.g., negative association between disengagement and parent-emerging adult relationships). Notable role differences between parents were observed across cultures. Implications include the use of this scale across diverse cultures.
Precession of the super-massive black hole in NGC 1275 (3C 84)?

The X-ray holes at the centre of the Perseus Cluster of galaxies are not all at the same position angle with respect to the centre of the cluster. This c onfiguration would result if the jet inflating the bubbles is precessing, or moving around, an d the bubbles detach at different times. The orientations which best fit the observed travel di rections are an inclination of the precession axis to the line of sight of 120 ◦ and an opening angle of 50 ◦ . From the timescales for the bubbles seen in the cluster, the precession timescal e, τprec, is around 3.3× 10 7 yr. The bubbles rising up through different parts of the cluster may have interacted with the central cool gas, forming the whorl of cool gas observed in the temperature structure of the cluster. The dynamics of bubbles rising in fluids is discussed. The con ditions present in the cluster are such that oscillatory motion, observed for bubbles rising i n fluids on Earth, should take place. However the timescale for this motion is longer than that taken for the bubbles to evolve into spherical cap bubbles, which do not undergo a path instability, so such motion is not expected to occur.
A Network Pharmacology Approach to Elucidate the Anti-inflammatory Effects of Ellagic Acid

Ellagic acid (EA) is a naturally occurring polyphenolic compound found in various fruits and vegetables like strawberries, raspberries, pomegranates, and nuts such as pecans and walnuts. With its antioxidant properties, EA has shown potential health benefits, although further research is necessary to fully comprehend its effects, mechanisms, and safe and effective application as a complementary medicine. Notably, there is accumulating evidence of EA’s anti-inflammatory effects; however, the precise underlying mechanism remains unclear. To investigate the anti-inflammatory properties of EA, a network pharmacology approach was employed. The study identified 52 inflammation-related targets of EA and revealed significant signaling pathways and relevant diseases associated with inflammation through GO and KEGG analysis. Furthermore, topological analysis identified 10 important targets, including AKT1, VEGFA, TNF, MAPK3, ALB, SELP, MMP9, MMP2, PTGS2, and ICAM1. Molecular docking and molecular dynamics simulations (integrated with were conducted molecular mechanics Poisson-Boltzmann), indicating that AKT1, PTGS2, VEGFA, and MAPK3 are the most likely targets of EA. In summary, this study not only confirmed the anti-inflammatory effects of EA observed in previous research but also identified the most probable targets of EA.
DNA elements tether canonical Polycomb Repressive Complex 1 to human genes

Development of multicellular animals requires epigenetic repression by Polycomb group proteins. The latter assemble in multi-subunit complexes, of which two kinds, Polycomb Repressive Complex 1 (PRC1) and Polycomb Repressive Complex 2 (PRC2), act together to effect the repression of key developmental genes. How PRC1 and PRC2 recognize specific genes remains an open question. Here we report systematic identification of DNA elements that tether canonical PRC1 to human developmental genes. Their analysis indicates that sequence features associated with PRC1 tethering differ from those that favour PRC2 binding. Throughout the genome, the two kinds of sequence features mix in different proportions to yield a gamut of DNA elements that range from those tethering predominantly PRC1 to ones capable of tethering both PRC1 and PRC2. The emerging picture is similar to paradigmatic targeting of Polycomb complexes by Polycomb Response Elements (PREs) of Drosophila but providing for greater plasticity.
On the excitation of nonlinear water waves by a moving pressure distribution oscillating at resonant frequency

A theoretical study is made of the free‐surface flow induced by a traveling oscillatory pressure distribution acting at the surface of water of finite depth. Depending on the relative values of the water depth and the frequency and speed of the applied pressure, the solution of the linearized water‐wave problem may be singular, owing to a resonance phenomenon. Through an asymptotic analysis, it is shown that, close to resonant conditions, the finite‐amplitude response is bounded, and it is governed by a forced nonlinear Schrodinger equation. It is deduced that, under certain circumstances, the generated wave disturbance may not reach a steady state; in particular, for deep water, a steady state is never attained.
Class switching is differentially regulated in RBC alloimmunization and vaccination

Background Studies of human patients have shown that most anti-RBC alloantibodies are IgG1 or IgG3 subclasses, though it is unclear why transfused RBCs preferentially drive these subclasses over others. Though mouse models allow for the mechanistic exploration of class-switching, previous studies of RBC alloimmunization in mice have focused more on the total IgG response than the relative distribution, abundance, or mechanism of IgG subclass generation. Given this major gap, we compared the IgG subclass distribution generated in response to transfused RBCs relative to protein in alum vaccination, and determined the role of STAT6 in their generation. Study Design and Methods WT mice were either immunized with Alum/HEL-OVA or transfused with HOD RBCs and levels of anti-HEL IgG subtypes were measured using end-point dilution ELISAs. To study the role of STAT6 in IgG class-switching, we first generated and validated novel STAT6 KO mice using CRISPR/cas9 gene editing. STAT6 KO mice were then transfused with HOD RBCs or immunized with Alum/HEL-OVA, and IgG subclasses were quantified by ELISA. Results When compared to antibody responses to Alum/HEL-OVA, transfusion of HOD RBCs induced lower levels of IgG1, IgG2b and IgG2c but similar levels of IgG3. Class switching to most IgG subtypes remained largely unaffected in STAT6 deficient mice in response to HOD RBC transfusion, with the one exception being IgG2b. In contrast, STAT6 deficient mice showed altered levels of all IgG subtypes following Alum vaccination. Discussion Our results show that anti-RBC class-switching occurs via alternate mechanisms when compared to the well-studied immunogen alum vaccination.
Engraftment of wild-type alveolar type II epithelial cells in surfactant protein C deficient mice

Childhood interstitial lung disease (chILD) secondary to pulmonary surfactant deficiency is a devastating chronic lung disease in children. Clinical presentation includes mild to severe respiratory failure and fibrosis. There is no specific treatment, except lung transplantation, which is hampered by a severe shortage of donor organs, especially for young patients. Repair of lungs with chILD represents a longstanding therapeutic challenge but cellular therapy is a promising strategy. As surfactant is produced by alveolar type II epithelial (ATII) cells, engraftment with normal or gene-corrected ATII cells might provide an avenue to cure. Here we used a chILD disease-like model, Sftpc−/− mice, to provide proof-of-principle for this approach. Sftpc−/− mice developed chronic interstitial lung disease with age and were hypersensitive to bleomycin. We could engraft wild-type ATII cells after low dose bleomycin conditioning. Transplanted ATII cells produced mature SPC and attenuated bleomycin-induced lung injury up to four months post-transplant. This study demonstrates that partial replacement of mutant ATII cells can promote lung repair in a mouse model of chILD.
Response inhibition in Premotor cortex corresponds 1 to a complex reshuffle of the mesoscopic information 2 network 3

12 Despite recent works that have investigated functional and effective neural networks in animal models, the dynamics of information propagation among functional modules underneath cognitive control is still largely unknown. Here, we addressed the issue using Transfer Entropy and graph theory methods on mesoscopic neural activities recorded in the dorsal premotor cortex of rhesus monkeys. We focused our analysis on the decision time of a Stop-signal task looking for hallmarks in the network functional configuration, when the Stop signal is presented, that could influence the motor plan maturation. When comparing trials with successful inhibition to those with generated movement the nodes of the network resulted organized in four clusters, hierarchically arranged, and distinctively partaking in information transfer. Interestingly, the hierarchies and the strength of the information exchanged between clusters varied during the task, being distinct for generated movements and canceled ones and coupled with distinct levels of network complexity. Our results suggest that the premotor contribution to motor decisions involves a topological reorganization of information,with the intrinsic features of the network that delineate its behavioral functionalities.
Testing linearity and relevance of ordinal predictors

: In a linear model relevance of a categorical predictor with or- dered levels is typically tested by use of the standard F -test (known from statistical textbooks). Such a test can also be applied for testing whether the regression function is linear in the ordinal predictor’s class labels. In this paper we propose an alternative (restricted) likelihood ratio test for these hypotheses which is especially suited for ordinal predictors and is based on the mixed model formulation of penalized dummy coeﬃcients. We show in simulation studies that the new test is more powerful than the standard F -test in many situations. The advantage of the new test is especially striking when the number of ordered levels is moderate or large. Using the relationship to mixed eﬀect models and robust existent ﬁtting software obtaining the test and its null distribution is very fast; a fast R implementation is provided.
Giants in the Local Region

We present parameter and abundance data for a sample of 298 nearby giants. The spectroscopic data for this work have a resolution of R ∼ 60,000, S/N > 150, and spectral coverage from 475 to 685 nm. Overall trends in the Z > 10 abundances are dominated by Galactic chemical evolution, while the light-element abundances are influenced by stellar evolution, as well as Galactic evolution. We find several super-Li stars in our sample and confirm that Li abundances in the first giant branch are related to mixing depths. Once astration of lithium on the main sequence along with the overall range of main-sequence lithium abundances are taken into account, the lithium abundances of the giants are not dramatically at odds with the predictions of standard stellar evolution. We find the giants to be carbon-diluted in accord with standard stellar evolution and that the carbon and oxygen abundances determined for the local giants are consistent with those found in local field dwarfs. We find that there is evidence for systematic carbon variations in the red giant clump in the sense that the blue side of the clump is carbon-poor (more diluted) than the red side.
New Laboratory Spectra of Isolated β-SiC Nanoparticles: Comparison with Spectra Taken by the Infrared Space Observatory

We present new laboratory infrared spectra of matrix-isolated β-SiC nanoparticles, which perfectly match the band profile of the 11+ μm feature observed in carbon stars. The new laboratory spectra differ in the shape of the band profile from former measurements of SiC nanoparticles thanks to the matrix-isolation technique which allows to obtain spectra of nonagglomerated particles. The final spectra are corrected for the influence of the surrounding medium (argon-matrix) by a computational technique proposed by Papoular et al. (1998). Furthermore, we study the influence of nitrogen incorporation into the SiC lattice, which introduces a strong near-infrared absorption owing to surface-plasmon excitation (Mutschke et al. 1999). Our laboratory spectra are compared with Infrared Space Observatory observations of several carbon stars showing an 11 μm feature either in emission or in absorption. We discuss the implications of the new laboratory results for the interpretation of the spectra of carbon stars.
Characterization of the plant community in a commercial dairy farm in Matanzas province, Cuba

Objective : To characterize the plant community of the pastureland in a dairy farm under commercial conditions in Matanzas province, Cuba. Materials and Methods : A study was conducted of the pastureland community on a Ferralitic Red soil, in a typical dairy farm of 120 animals and an area of 72,4 ha. From them, 57,8 dedicated to grazing, distributed in 29 paddocks of 1,9 ha each as average. The variables pasture availability, floristic composition of the pastureland, stocking rate and forage balance, were analyzed. Results : The natural pastures predominated in the system, with a contribution of more than 60,0 % in the dry season and close to 70,0 % in the rainy season. The species Paspalum notatum Alain ex Flügé, Dichanthium annulatum (Forssk.) Stapf and Dichanthium caricosum (L.) A. Camus prevailed. The highest pasture yield was obtained in the rainy season (2,86 t/ha) and the lowest value, in the dry season (1,79 t/ha). Nevertheless, the dry matter supply throughout the year did not exceed 16 kg DM/animal/day. The effective stocking rate values (1,3 LAU/ha) exceeded the established optimum value. The forage balance showed a dry matter deficit higher than 3,0 kg /LAU/day in both seasons. Conclusions : The low pasture yield throughout the year was linked to the high predominance of natural species and weeds present in the pastureland. The highest availability was reached in the rainy season. The stocking rate values are over the optimum value.
Fusion cutting of aluminum, magnesium, and titanium alloys using high-power fiber laser

Abstract. The effects of cutting speed and assist gas pressure on laser cutting of 1-mm thick Al 1050, AZ31, and Ti6Al4V lightweight alloys are experimentally investigated. Fiber laser cutting of these materials is not broadly investigated and the acquisition of a new level of knowledge is of fundamental importance for applications like sheet metal trimming in automotive industry. The main process outputs are in depth compared with results reported in literature and obtained by cutting with CO2 and Nd∶YAG lasers. The good cut quality, the high productivity, and the easy delivery of the beam obtained at the same time, corroborate the advantage of using fiber lasers for thin sheets lightweight alloys cutting.
The magnetostrophic rise of a buoyant parcel in the Earth's core

Accepted 1993 September 21. Received 1993 September 21; in original form 1993 April 30 SUMMARY The dynamics of a buoyant parcel (or blob) of fluid released from the mushy zone on the inner core boundary (ICB) is considered. Estimates of the density defect and of the rise velocity are obtained from consideration of mass conservation and magnetostrophic force balance. When Lorentz and Coriolis forces are of comparable orders of magnitude, the disturbance remains localized in a neighbourhood of the blob even in the absence of viscous effects, and an inviscid analysis is possible. The instantaneous velocity and magnetic field associated with a given localized buoyancy distribution are then determined, and on the assumption that the velocity is approximately uniform throughout the blob, its trajectory from ICB to core-mantle boundary (CMB) is deduced. Both westward drift and poleward migration of erupting field loops are indicated. The effects of turbulent diffusion on the blob are considered. The prospects for constructing a dynamo theory based on this ‘blob scenario’ are discussed.
Quantum and classical probability distributions for position and momentum

The classical and quantum probability distributions for both position and momentum are compared for several model systems admitting bound states including the harmonic oscillator, the infinite well, and the linear confining potential (V(x)=F‖x‖). Examples corresponding to unbound systems, including the uniformly accelerating particle and the motion of a particle moving away from a point of unstable equilibrium, i.e., the ‘‘unstable oscillator’’ defined by V(x)=−kx2/2, are also considered. The quantum and classical distribution of kinetic and potential energy for the harmonic oscillator is briefly discussed.
Ultracompact tapers for light coupling into two-dimensional slab photonic-crystal waveguides in the slow light regime

Optical coupling from a strip waveguide to a two-dimensional photonic crystal (PC) slab waveguide in the slow light regime is investigated. Group-velocity mismatch between optical modes is responsible for large coupling loss. Typical devices based on a W1 PC waveguide, with strip input and output waveguides on each side, are studied using finite-difference time-domain and plane-wave expansion calculations. Compact tapers based on PC lattice parameter tuning are proposed to reduce the coupling loss. At 1.6 μm, for an optical mode with group velocity v g /c=0.054, the transmission can be enhanced from 18% without tapers to 95% with a 3.4-μm-long taper on each side of the PC.
LINKING OF RANDOM p-SPHERES IN Zd

We consider the number of embeddings of k p-spheres in Zd, with p+2≤d≤2p+1, stratified by the p-dimensional volumes of the spheres. We show for p+2<d that the number of embeddings of a fixed link type of k equivolume p-spheres grows with increasing p-dimensional volume at an exponential rate which is independent of the link type. For d=p+2 we derive similar results both for links of unknotted p-spheres and for "augmented" links where each component p-sphere can have any knot type, and similar but weaker results when the spheres are of specified knot type.
Defect reduction of selective Ge epitaxy in trenches on Si(001) substrates using aspect ratio trapping

Defect-free germanium has been demonstrated in SiO2 trenches on silicon via Aspect Ratio Trapping, whereby defects arising from lattice mismatch are trapped by laterally confining sidewalls. Results were achieved through a combination of conventional photolithography, reactive ion etching of SiO2, and selective growth of Ge as thin as 450nm. Full trapping of dislocations originating at the Ge∕Si interface has been demonstrated for trenches up to 400nm wide without the additional formation of defects at the sidewalls. This approach shows great promise for the integration of Ge and/or III-V materials, sufficiently large for key device applications, onto silicon substrates.