Miracle-dz/UniFAR-FTUs huggingface dataset:
Randomized Placebo-Controlled Clinical Trials Testing Gemfibrozil for Smoking Cessation and Melatonin for Alcohol-related Sleeping Problems

Substance use disorder (SUD) is not a temporary condition but it is a chronic and relapsing disorder that leads to serious health risks. SUD is considered a pathological behavior, affecting the reward circuit and stress system, and these impairments can last for a longer period even after detoxification and abstinence. The motivation behind exploring new therapeutic options for different kind of SUDs and their complications is the limited success of the available treatments. For instance, the Food and Drug Administration (FDA) approved medications for Tobacco use disorder (TUD) increase abstinence rates; however, relapse remains the most likely outcome, with success rates of only 20-30% at 1 year post-treatment follow up. The other motivation for exploring new therapeutics is the harmful side effects caused by current medications; for instance, the use of benzodiazepine receptor agonists, to treat alcohol use disorder (AUD)-sleep disorder, which are known to be addictive. This thesis focuses on two randomized clinical trials (RCTs) exploring the effect of two therapeutic options one for TUD using lab paradigms for nicotine craving and reinforcement and a brief quit attempt. The other RCT is exploring the effect of melatonin for sleep problems in AUD subjects for four weeks of treatments monitoring
GPX7 promotes the growth of human papillary thyroid carcinoma via enhancement of cell proliferation and inhibition of cell apoptosis

Background Abnormal expression of glutathione peroxidase 7 (GPX7) has been linked to the occurrence and development of a variety of tumors. However, the role of GPX7 in the progression of papillary thyroid carcinoma (PTC) has not been elucidated. This study investigated the role of GPX7 in the progression of PTC. Methods The methods employed included immunohistochemistry, Western blotting, quantitative reverse transcription-polymerase chain reaction (qRT-PCR), MTT assay, Celigo cell counting, flow cytometric analysis, caspase activity assay, cell clone formation assay, and GPX7 knockdown. Results The data showed that GPX7 protein was localized in the cytoplasm of thyroid cells. The level of GPX7 expression was higher in PTC tissues than in the nodular goiter. The positive rate for GPX7 was also higher in the PTC group than in the nodular goiter group (100.0% vs. 35.7%). The maximum tumor diameter in the group highly expressing GXP7 was significantly greater than that in the group with low expression of GXP7 (1.56±0.56 vs. 0.56±0.13 cm, P<0.001). The GPX7 mRNA level was higher in K1 cells. Knockdown of GPX7 decreased the number of cells, cell clone formation ability, and cell proliferation rate and increased the activity of caspase 3/7 and cell apoptosis in PTC K1 cells. Conclusions These results indicate that high expression of GPX7 increases the proliferation and reduces the apoptosis of PTC cells, and thus, promotes the growth and progression of human PTC.
Research Interest Assessment Among Dental Students at King Abdulaziz University Faculty of Dentistry

Background: Evidence-based decision-making in dentistry is critical to modify and improve healthcare protocols. Thus, the aim of our study was to assess research interest among dental students at King Abdulaziz University, Faculty of Dentistry (KAUFD) and elucidate if they understand and appreciate the importance of Evidence-Based Dentistry (EBD) in recent dental advances. Methods: A questionnaire was formulated and sent to dental students at KAUFD from the academic year of 2013-2014 (n=751). The questionnaire included nine English questions. These questions were intended to assess research experience as well as understanding and appreciating EBD in the advances of dentistry. The questions also determined if the dental students at the current curriculum are publishing scientific articles within or just after their graduation from dental school. In addition, the questionnaire covered questions regarding the students’ future plans during summer vacations and after graduation. The data were analyzed using IBM SPSS version 20. The chi-square test was used to establish a relationship between categorical variables, and statistical significance was defined as p ≤ 0.05. Results: The response rate was 68.17%. Most participants were female students (67%). About 59.7% of the participants have research experience. The majority of the participants identified the 4th year as the most appropriate time for dental students to start participating in research (44.7%). Students believed that practicing dentistry should be based on both EBD and clinical experience (73.4 %); 61.6% believed that clinical experience is more important. Of all participants, 59.3% did not have scientific publications or papers in preparation for publication. Conclusions: Knowledge and awareness of research importance in the advances of our dental field need to be emphasized for dental students at KAUFD. The misconception that clinical experience is more important than EBD must be revised. Students should be encouraged to graduate with scientific published papers. This can strengthen their promise in future postgraduate studies and can open different career opportunities.
Significance of peritoneal cytology in patients with gastric cancer: a mono institutional experience with 50 patients

Peritoneal cytology was considered positive when malignant cancer cells were found in the smears. Medical records of each patient were then reviewed in detail and relevant clinical and pathological information were obtained . The patients were then followed for recurrence of disease and mortality either in our follow up clinic or by telephonic conversation. Associations between cytology status (CY) and clinicopathological variables and effect of cytology status on overall survival was evaluated.
Spatial Variability of Dissolved Organic Carbon, Solutes, and Suspended Sediment in Disturbed Low Arctic Coastal Watersheds

Climate change in the Arctic leads to permafrost degradation and to associated changes in freshwater geochemistry. There is a limited understanding of how disturbances such as active layer detachments or retrogressive thaw slumps impact water quality on a catchment scale. This study investigates how permafrost degradation affects concentrations of dissolved organic carbon (DOC), total dissolved solids (TDS), suspended sediment, and stable water isotopes in adjacent Low Arctic watersheds. We incorporated data on disturbance between 1952 and 2015, as well as sporadic runoff and geochemistry data of streams nearby. Our results show that the total disturbed area decreased by 41% between 1952 and 2015, whereas the total number of disturbances increased by 66% in all six catchments. The spatial variability of hydrochemical parameters is linked to catchment properties and not necessarily reflected at the outflow. Degrading ice‐wedge polygons were found to increase DOC concentrations upstream in Ice Creek West, whereas hydrologically connected disturbances were linked to increases in TDS and suspended sediment. Although we found a great spatial variability of hydrochemical concentrations along the paired watershed, there was a linear relationship between catchment size and daily DOC, total dissolved nitrogen, and TDS fluxes for all six streams. Suspended sediment flux on the contrary did not show a clear relationship as one hydrologically connected retrogressive thaw slump impacted the overall flux in one of the streams. Understanding the spatial variability of water quality will help to model the lateral geochemical fluxes from Arctic catchments.
Finding Customer Perception of Peer-to-Peer (P2P) Lending Financial Technology in Pohon Dana

The research aimed to discover some factors influencing customer perception toward Peer-to-Peer (P2P) lending Financial Technology (FinTech). It was an empirical study in which the survey was conducted using an online questionnaire from June to August 2019. The research sample was collected from 56 respondents of Pohon Dana customers by simple random sampling. The data collected were analyzed with Partial Least Square Path Modelling by presenting several factors influencing customer perception. The analysis tool was SmartPLS ver 3.2. 8. The research finds out that benefits and security have a positive and significant relationship to customer perception. Meanwhile, ease of use, self-efficacy, and trust have a negative and insignificant relationship to customer perception.
Deformation of Intrasalt Beds Recorded by Magnetic Fabrics

Intrasalt beds comprise sedimentary layers within a weak rock salt mass. Thick intrasalt beds (hundred meter scale) are common in salt structures, yet their internal deformation has not been investigated in detail as outcrops of such beds are rare. In this study, we explore the internal deformation of thick intrasalt beds exposed along the Sedom salt wall in the Dead Sea Basin. These beds are highly deformed and form a kilometer‐scale recumbent fold. We measured the magnetic fabrics from six sites along these beds. Magnetic fabrics reflect the preferred alignment of crystals and grain shapes and are a proven kinematic marker in deformed rocks. Our analysis shows that the magnetic fabrics are mostly controlled by the preferred orientation of clay minerals. The orientations of the principal susceptibility axes vary along the salt wall regardless of the specific rock type. Minimum susceptibility axes (K3 axes) are normal to bedding, whereas maximum susceptibility axes (K1 axes) are subparallel to bedding strike. We suggest that the magnetic fabrics were acquired by strain imposed at a necked region along a subsurface fault, together with folding during passive diapirism. Generally, the magnetic fabrics have not been influenced by the later stage of active diapirism, which led to emergent beds at the surface. Nevertheless, in sites from the upper limb of the recumbent fold, the magnetic fabrics were further deformed by folding at the base of a salt glacier. Our results demonstrate that thick intrasalt beds are mechanically distinct from the encasing flowing salt and preserve information on salt tectonic processes operating at depth.
Evaluating Acceptability, Feasibility and Efficacy of a Diabetes Care Support Program Facilitated by Cellular-Enabled Glucose Meters: A Dissertation

Background. Diabetes requires significant disease management, patient-provider communication, and interaction between patients, family members, caregivers, and care teams. Emerging patient-facing technologies, such as cellular-enabled glucose meters, can facilitate additional care support and improve diabetes self-management. This study evaluated patient acceptability, feasibility, and efficacy of a diabetes care support program facilitated by cellular-enabled glucose meters. Methods. A two-phase study approach was taken. Get In Touch – Phase 1 (GIT-1) was a 1-month pilot involving patients with type 1 and type 2 diabetes. Get In Touch – Phase 2 (GIT-2) was a 12-month randomized controlled crossover trial involving patients with poorly-controlled type 2 diabetes. Results from GIT-1 and preliminary results from GIT2 are presented. Results. GIT-1 participants with type 1 (n=6) and type 2 (n=10) diabetes reported the intervention and cellular-enabled glucose meter were easy to use and useful while identifying potential areas of improvement. GIT-2 participants in both the intervention (n=60) and control (n=60) groups saw significant improvements in treatment satisfaction and A1c change, with intervention participants experiencing slightly greater improvements in each after 6 months (p=0.09 and p=0.16, respectively) compared to control participants. Conclusions. Patients reported favorable acceptability of the intervention. Preliminary results from a randomized trial demonstrated potential of intervention to improve patientreported and physiological health outcomes. Future studies should evaluate feasibility and efficacy over a longer period of time, with a greater number of participants, and targeting different populations of patients with diabetes. Provider perspectives and changes in provider behavior, clinical work flow, and caregiver burden should also be assessed.
The function of eco-lexicons in conservation news texts published in mass media

Tommi Yuniawana*, Fathur Rokhmanb, Rustonoc, Hari Bakti Mardikantorod, Ida Zulaehae, Untung Yuwonof, Harun Joko Prayitnog, Muhammad Rohmadih, a,b,c,d,eFaculty of Languages and Arts, Universitas Negeri Semarang, fFaculty of Humanities, Universitas Indonesia, gFaculty of Teacher Training and Education Universitas Muhammadiyah Surakarta, hFaculty of Teacher Training and Education, Universitas Sebelas Maret, Email: a*tommiyuniawan@mail.unnes. ac.id
Correlation Between Thyroid Function and Obesity

To review the study on markers associated with thyroid functioning like obesity. In earlier studies it was found that thyroid functioning and obesity in children was related . But no concrete proof was found. This is to review the validity of the article on relations of thyroid hormones with obesit. Now a days children suffer from various problems like obesity due to changes the new life styles being followed. By this study we can asses the problems and understand how we can improve their lives. As children are our future its is important to make sure that their state of mind and health is always taken care of.
PREVALENCE OF LOW BACK PAIN AMONG THE UNDERGRADU- ATE STUDENTS OF ISRA UNIVERSITY KARACHI CAMPUS

Background: LBP is a condition with a high prevalence and recurrence rate. This condition has the potential to create a major impact on the individual over extended periods of time. Numerous reasons and factors for lower back pain have been suggested; including age, gender, body mass index (BMI) and physical activity of the patient. There are different treatments and techniques being implemented, however their effects are minimal. Students at University level are at high risk of LBA due to prolonged sitting and standing hours. Methods: Research was conducted on 190 students of ISRA University, Karachi Campus. The duration of the study was 6 months, the participants were randomly selected, who were studying in ISRA University, Karachi Campus and self-administered questionnaires with consent forms were distributed to all the participants. Participants were asked to complete the questionnaire and return it to the concerned person after one week. Results: 71.6% had history of low back pain whereas 28.4% did not have history of low back pain. 84.7% students used computer whereas 15.3% did not use computer. 65.3% left the class room due to low back pain whereas 34.7% did not leave the class room. 61.6% students had prevented normal work from 1-7days due to low back pain during last 12 months, 26.8% prevented normal work from 0 days whereas 11.6% students had prevented normal work from 8-30days due to low back pain during last 12 months. Conclusion: The overall aim of this study was to analyze the prevalence of low back pain among the undergraduate students of ISRA University, Karachi Campus. The study provided a detailed awareness about the level of prevalence of lower back pain among the undergraduate students. The results of this study showed that most of the students were experiencing lower back pain, and it was also found that it is directly related to their work.
Understanding Community Assembly Based on Functional Traits, Ontogenetic Stages, Habitat Types and Spatial Scales in a Subtropical Forest

Community assembly in natural communities is commonly explained by stochastic and niche-based processes such as environmental filtering and biotic interactions. Many studies have inferred the importance of these processes using a trait-based approach, however, there are still unknowns around what factors affect the importance of different assembly processes in natural communities. In this study, the trait dispersion patterns of 134 species were examined across different functional traits, habitat types, ontogenetic stages and spatial scales from a 20-ha Dinghushan Forest Dynamic Plot in China. The results showed that (1) functional traits related to productivity such as specific leaf area and leaf area mainly showed functional clustering, indicating these two functional traits were more affected by environmental filtering. However, trait dispersion patterns depended on more than the ecological significances of functional traits. For example, trait dispersions of leaf dry matter content, leaf thickness and maximum height did not show consistent patterns across habitat types and ontogenetic stages, suggesting more complex mechanisms may operate on these traits; (2) the trait dispersion varied with the habitat types and ontogenetic stages. Specifically, we found that habitat types only affected the strength of trait dispersions for all the five traits, but ontogenetic stages influenced both the strength and direction of trait dispersions, which depended on the traits selected; (3) the relative importance of soil, topography and space to trait dispersion varied with ontogenetic stages. Topography and space were more important for trait dispersion of saplings but soil was more important for trait dispersion of adults; (4) biotic interactions dominated community assembly at smaller spatial scales but environmental filtering dominated community assembly at larger spatial scales. Overall, the results highlight the importance of functional traits, habitat types, ontogenetic stages and spatial scales to community assembly in natural communities.
AGRONOMIC PERFORMANCE AND PHOTOSYNTHETICALLY ACTIVE RADIATION INTERCEPTED BY MAIZE INTERCROPPED WITH BRACHIARIA

Maize and soybean are the main crops used for crop yield on Brazilian Cerrado biome. The off-season maize intercropped with ruzigrass [ Urochloa ruziziensis (R. Germ. & C.M. Evrard) Crins (Syn. Brachiaria ruziziensis Germ. & Evrard)] increases soil cover and yield for crops in succession. However, the benefits on maize yield depend on the distribution and radiation-use efficiency (RUE) and its conversion to biomass. This study aimed to evaluate maize and ruzigrass yield in different cultivation systems. The experiment was carried out at Embrapa Agropecuária Oeste, in Dourados, MS, Brazil. The experiment design was randomized blocks, with seven treatments constituted by the combination of spacing between maize rows, single and intercropped, with ruzigrass in distribution methods. Photosynthetically active radiation, chlorophyll, leaf temperature, morphological characteristics and maize mass yield were evaluated in maize at the flowering stage (R1). Maize and ruzigrass yield were evaluated during maize maturation. The reduced spacing in single maize has a higher yield and lower radiation incidence in the ear. Maize intercropped with ruzigrass sown by broadcasting showed higher leaf temperature, lower plant height and lower maize leaf area. Morphological and physiological characteristics and maize grain yield were more influenced by planting methods than the presence of ruzigrass. The highest yield of dry matter and maize grain occurred in reduced spacing in maize, either alone or intercropped with ruzigrass.
Variations in Naturalistic Driving Behavior and Visual Perception at the Entrances of Short, Medium, and Long Tunnels

Driver behavior and visual perception are very important factors in the management of traffic accident risk at tunnel entrances. This study was undertaken to analyze the differences in driving behavior and visual perception at the entrances of three types of tunnels, namely, short, medium-length, and long tunnels, under naturalistic driving conditions. Using three driving behavior indicators (speed, deceleration, and position) and two visual perception indicators (fixation and saccade), the driving performance of twenty drivers at six tunnels (two tunnels per condition) was comparatively analyzed. The results revealed that the speed maintained by the drivers prior to deceleration with braking under the short-tunnel condition was significantly larger than that under the medium- and long-tunnel conditions and that the drivers had a greater average and maximum deceleration rates under the short-tunnel condition. A similar general variation of driver visual perception appeared under the respective tunnel conditions, with the number of fixations gradually increasing and the maximum saccade amplitude gradually decreasing as the drivers approached the tunnel portal. However, the variation occurred approximately 60 m earlier under the short-tunnel condition than under the medium- and long-tunnel conditions. Interactive correlations between driving behavior and visual perception under the three conditions were established. The commencement of active deceleration was significantly associated (with correlation factors of 0.80, 0.77, and 0.79 under short-, medium-, and long-tunnel conditions, respectively) with the point at which the driver saccade amplitude fell below 10 degrees for more than 3 s. The results of this study add to the sum of knowledge of differential driver performance at the entrances of tunnels of different lengths.
Multidrug-resistantPseudomonasaeruginosaisolated from ear and wound swabs in some selected hospital laboratories in Sokoto Metropolis, Nigeria

Pseudomonas aeruginosais a metabolically versatile bacterium that can cause a wide range of severe opportunistic infections in patients with serious underlying conditions and can be found in most communities in Nigeria. The study was to determine the prevalence, resistance pattern and distribution of multiple drug resistantP. aeruginosa(MDR-PA) isolated from ear and wound specimens in patients attending Specialist Hospital Sokoto and Maryam Abacha Women and Children Hospital Sokoto.A total of 150 samples were analysed by standard bacteriological methods. Screening for MDR-PA was carried out by antibiotic sensitivity testing using disc diffusion method with ceftazidime (30 µg), ofloxacin (5 µg), cefuroxime (30 µg), cloxacillin (30 µg), amoxicillin (30 µg), ceftriaxone (30 µg), imipenem (10 µg), gentamycin (10 µg) and colistin (10 µg) discs on Mueller Hinton agar.Of a total of 55 (36.7%) isolates ofP. aeruginosastrains were obtained, 30 (54.5%) isolates were resistant to imipenem, 31 (56.3%) were resistant to ofloxacin, 44 (80.0%) to gentamycin, 53 (96.3%) to ceftazidime and cefuroxime, 50 (90.9%) to ceftrizone, 54 (98.1%) to cloxacillin and amoxycillin and lastly 15 (27.2%) to colistin. All the isolates were multi drug resistant, this probably due to improper use or over the counter purchase of antibiotics without professional oversight.Almost all the isolates were resistant to all the antibiotics used including colistin. There is need to improve on the public health awareness on the indiscriminate use of antimicrobial agents as it is one of the major ways microbes develop resistance to them.