Miracle-dz/UniFAR-FTUs huggingface dataset:
Rare Copy Number Variation In an Extremely Impulsively Violent Males:

1 Department of Psychiatry, Faculty of Medicine and University Hospital in Pilsen, Charles University, Czech Republic 2 Department of Psychiatry, First Faculty of Medicine, Charles University and General University Hospital in Prague, Czech Republic 3 Institute for Postgraduate Medical Education, Prague, Czech Republic 4 The Centre for Applied Genomics and Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON M5G 04A, Canada. 5 Research Unit for Rare Diseases, Department of Pediatrics and Adolescent Medicine, First Faculty of Medicine, Charles University, Prague, Czech Republic 6 Prison Service of the Czech Republic, Directorate General, Department of Psychology, Prague, Czech Republic 7 Psychology Department, University of New York in Prague, Prague, Czech Republic 8 Psychology Department, National Institute of Mental Health, Klecany, Czech Republic 9 Children's Faculty Hospital, Department of Pediatrics and Adolescent Medicine, Kosice, Slovakia 10 Faculty of Medicine of Pavel Jozef Šafárik University Kosice, Kosice, Slovakia 11 Sir James Spence Institute, Royal Victoria Infirmary, Queen Victoria Road, Newcastle upon Tyne, NE1 4LP, United Kingdom 12 Section on Nephrology, Wake Forest School of Medicine, Medical Center Blvd., WinstonSalem, NC 27157, USA
Longitudinal lung function assessment of patients hospitalised with COVID-19 using 1H and 129Xe lung MRI

Introduction: Microvascular abnormalities and impaired 129Xe gas transfer have been observed in patients with COVID 19. The progression of pathophysiological pulmonary changes during the post acute period in these patients remains unclear. Methods: Patients who were hospitalised due to COVID 19 pneumonia underwent a pulmonary 1H and 129Xe MRI protocol at 6, 12, 25 and 50 weeks after hospital admission. The imaging protocol included: ultra short echo time, dynamic contrast enhanced lung perfusion, 129Xe lung ventilation, 129Xe diffusion weighted and 129Xe 3D spectroscopic imaging of gas exchange. Results: 9 patients were recruited and underwent MRI at 6 (n=9), 12 (n=9), 25 (n=6) and 50 (n=3) weeks after hospital admission. At 6 weeks after hospital admission, patients demonstrated impaired 129Xe gas transfer (RBC:M) but normal lung microstructure (ADC, LmD). Minor ventilation abnormalities present in four patients were largely resolved in the 6 to 25 week period. At 12 week follow up, all patients with lung perfusion data available (n=6) showed an increase in both pulmonary blood volume and flow when compared to 6 weeks, though this was not statistically significant. At 12 and 25 week follow up, significant improvements in 129Xe gas transfer were observed compared to 6 week examinations, however 129Xe gas transfer remained abnormally low. Conclusions: This study demonstrates that multinuclear MRI is sensitive to functional pulmonary changes in the follow up of patients who were hospitalised with COVID 19. Persistent impairment of xenon transfer may represent a physiological mechanism underlying ongoing symptoms in some patients and may indicate damage to the pulmonary microcirculation.
Anomalous stress field and active breaching at relay ramps: a field example from Gediz Graben, SW Turkey

Relay ramps form at different scales in extensional terrains to accommodate the differential stretching among the overlapping bounding-normal fault segments. The major boundary structure of the Gediz Graben (SW Turkey) is segmented, with formation, evolution and active breaching of relay ramps. The Akçapınar relay ramp is an example of these processes that forms within a 2 km wide overlap zone between ∼ E–W-trending segments on the southern margin of the Gediz Graben. Change of structural style at the ramp area is clearly evident from variations in the orientation of fractures and faults of the relay ramp. As a site of local stress field anomaly, ∼ N–S-trending structures in the Akçapınar relay ramp are conformable with the extension that is parallel to the bounding faults of the relay ramp. These structures are also superimposed onto the ∼ E–W-trending regional structural style by an obvious cross-cutting relationship, suggesting both spatial and temporal variation of the state of stress at the ramp area during the relay ramp formation. The regional stress field and the resulting regional structural style characterize the earlier stages of ramp evolution, during which segment interaction is limited. As segment interaction and relay ramp formation advances towards the breaching phase, an anomalous local stress field arises and the relay ramp area experiences extension parallel to the bounding normal faults, that is, transverse to the regional direction of extension. This creates a new structural style at the ramp area.
Evaluation of a phosphate management protocol to achieve optimum serum phosphate levels in hemodialysis patients.

OBJECTIVE To evaluate the effectiveness of a protocol designed to optimize serum phosphate levels in patients undergoing regular hemodialysis (HD). DESIGN Randomized, controlled trial. SETTING Hemodialysis units at Barts and the London NHS Trust and satellite units. PATIENTS Thirty-four clinically stable adults undergoing regular HD with a serum phosphate level >1.8 mmol/L on at least one occasion within 4 months of starting the study. INTERVENTION Management of serum phosphate using a specially designed phosphate management protocol during a 4-month study period implemented by a renal dietitian and renal pharmacist compared with standard practice. MAIN OUTCOME MEASURE Change in serum phosphate levels in both groups after 4 months. RESULTS Patients managed using the phosphate management protocol had a significantly greater reduction in serum phosphate levels compared with patients receiving standard practice (-0.22 +/- 0.67 mmol/L vs. +0.19 +/- 0.32 mmol/L, P = 0.03). CONCLUSION The phosphate management protocol was effective, and its implementation was associated with significantly better serum phosphate control in patients undergoing regular HD.
Measurement of the Nuclear Modification Factor and Prompt Charged Particle Production in p-Pb and pp Collisions at sqrt[s_{NN}]=5  TeV.

The production of prompt charged particles in proton-lead collisions and in proton-proton collisions at the nucleon-nucleon center-of-mass energy sqrt[s_{NN}]=5 TeV is studied at LHCb as a function of pseudorapidity (η) and transverse momentum (p_{T}) with respect to the proton beam direction. The nuclear modification factor for charged particles is determined as a function of η between -4.8<η<-2.5 (backward region) and 2.0<η<4.8 (forward region), and p_{T} between 0.2<p_{T}<8.0 GeV/c. The results show a suppression of charged particle production in proton-lead collisions relative to proton-proton collisions in the forward region and an enhancement in the backward region for p_{T} larger than 1.5 GeV/c. This measurement constrains nuclear PDFs and saturation models at previously unexplored values of the parton momentum fraction down to 10^{-6}.
Activity-Dependent Bulk Endocytosis and Clathrin-Dependent Endocytosis Replenish Specific Synaptic Vesicle Pools in Central Nerve Terminals

Publisher Rights Statement: ''After six months, anyone may use the material for non-commercial purposes under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License (http://creativecommons.org/licenses/by-nc-sa/3.0). This agreement allows data and text mining, use of figures in presentations, and posting the article online, as long as the original article is attributed. '' www.jneurosci. org/site/misc/Permissions_Policy. pdf
The Lower Zone–Critical Zone Transition of the Bushveld Complex: a Quantitative Textural Study

The Lower Zone---Critical Zone boundary of the Bushveld Complex is an intrusion-wide, major stratigraphic transition from ultramafic harzburgite and pyroxenite in the Lower Zone to increasingly plagioclase-richpyroxenitesandnoritesintheCriticalZone.Quantitative textural and compositional data for 29 samples through this transition show the following: Lower Zone orthopyroxene grains are larger, have higher aspect ratios, are better foliated and have a lower trapped liquid component than those of the Critical Zone. The larger grain size of the Lower Zone results in crystal size distribution plots that are rotated to lower slopes and intercepts relative to those in the Critical Zone. Although all rocks show differing amountsoffoliation, mineral lineations are weak to absent. These data are consistent with significant compaction-driven recrystallization in the study section. Numerical modeling of concurrent compaction and crystallization provides a quantitative model of how the Lower Zone---Critical Zone transition may have formed: plagioclase is rare in the Lower Zone because compaction removes interstitial liquid before it reaches plagioclasesaturation.However,asthecrystalpilegrows,plagioclase saturation is reached in the interstitial liquid before compaction is complete in more evolved pyroxenites, producing more abundant but still modest amounts of plagioclase characteristic of the Lower Critical Zone. It is concluded that both the textures and the modal mineralogy are largely controlled by compaction and compactiondriven recrystallization; primary magmatic textures are not preserved.
Hydrate occurrences in the Namibe Basin, offshore Namibia

Abstract Seismic data has long suggested the presence of methane hydrates offshore Namibia. The seismic data shows the presence of well-developed bottom-simulating reflectors which can be mapped over a large area. A recent seabed coring programme has confirmed the presence of hydrates in the Namibe Basin. The hydrates appear to be associated with slump features and are a drilling hazard as well as a potential resource. The methane hydrate appears to originate from both biogenic and thermogenic sources.
Study of the weekday-weekend variation of air pollutants in a typical Mediterranean coastal town

A study of the air pollution in the Greek coastal town Volos was performed using the available data of the last ten years. Quantile analysis showed that ozone concentrations during weekends were higher by 5–10% in comparison to those on weekdays, while the inverse was observed for the other pollutants, indicating the occurrence of the so called 'weekend effect'. Analysis of the maximum values of the high ozone period showed even higher differences. The pollutants NO, NO2, CO, and SO2 were lower during weekends compared to weekdays, by about 30%, 20%, 25% and 10% respectively.
Substorms, Storms, and the Near-Earth Tail

More than 50, 000 measurements made with the AMPTE IRM satellite in the magnetotail at radial distances between 10 and 19 RE during 40 substorms have been used in a super-posed epoch analysis, separating storm-time substorms from those occurring during intervals of low Dstt levels. It is found that most of the tail signatures reported previously as typical for substorms are strongly influenced by magnetic storm activity. The magnetic field dipolarization and the Earthward convection in the near-Earth tail are much more pronounced for substorms which occur during the main phase of magnetic storms than for non-storm substorms. Moreover, only for storm-time substorms the lobe magnetic pressure decreases during the expansion phase. These findings indicate that not all substorms are alike and that the near-Earth neutral line scenario may apply only to the storm-time substorms.
Caesium‐137 soil sampling and inventory variability in reference locations: A literature survey

Soil sampling design, the number of samples collected and the lateral variation of caesium-137 ( 137 Cs) in uneroded reference locations were extracted from previously published work. The focus was on published work which used 137 Cs reference inventory (Bq m -2 ) for qualitative or quantitative estimation of sediment redistribution (SRD) within the landscape. The objective of this study was to address one of the methodological concerns facing the 137 Cs technique - that is, the lack of a rigorous statistical treatment of reference locations. The limited attention paid to the reference location is not justified as 'true' estimates of SRD are based on the assumption of an unbiased, independent, random probability sample estimate, commonly the arithmetic mean. Results from the literature survey indicated that only 11% of the reference locations sampled for 137 Cs expressly stated that a probability sampling design was used (transect or systematic-aligned grid). The remaining locations were generally sampled using a non-probability based design, more commonly known as haphazard sampling. Of the 75 reference study areas identified only 40 provided enough information to determine the dispersion around the mean, and from this the coefficient of variation (CV) was calculated for all available data. The median CV was 19.3%, with 95% confidence limits of 13.0-23.4%, indicating that approximately 11 random, independent samples would generally be necessary to adequately quantify the reference 137 Cs area activity with an allowable error of 10% at 90% confidence. Further analysis indicated that only one-third of the studies sampled a sufficient number of 137 Cs reference locations. This value would actually be lower as sampling frameworks were based on non-probability sampling procedures. For 137 Cs reference locations it is recommended that a probability sampling design be utilized, preferably the systematic-aligned grid method, and as a minimum first-order estimate about 11 samples should be collected for inventory estimates.
Holocene stratigraphic and morphological evolution of the Wandandian Creek delta, St Georges Basin, New South Wales

Subaerial exposure beside the Wandandian Creek channel during the last glacial maximum led to the development of red and orange mottling and, in some areas, produced a palaeosol over the Pleistocene land surface. Incision of the palaeo-Wandandian Creek, during the Late Pleistocene, formed a relatively deep steep-sided channel partially infilled with medium-grained fluvial sand. This palaeovalley became drowned as the post-glacial marine transgression impounded the western portion of St Georges Basin and the basal prodelta/lagoonal mud facies was deposited from ca 7 ka. The Wandandian Creek delta prograded down the palaeovalley and reached the study area ∼3500 – 4000 years ago with the deposition of delta-front sandy silt and the overlying prograded sand facies. The subaerial portion of the delta is characterised by well-developed floodplains, levees, mouth bars and backswamps. Dredging in Wandandian Creek and land clearing for rural and urban development have had little long-term effect on the growth and morphology of Wandandian Creek delta.
Community vulnerability to climate change in the context of other exposure-sensitivities in Kugluktuk, Nunavut

Climate change in the Canadian north is, and will be, managed by communities that are already experiencing social, political, economic and other environmental changes. Hence, there is a need to understand vulnerability to climate change in the context of multiple exposure-sensitivities at the community level. This article responds to this perceived knowledge need based on a case study of the community of Kugluktuk in Nunavut, Canada. An established approach for vulnerability assessment is used to identify current climatic and non-climatic exposure-sensitivities along with their associated contemporary adaptation strategies. This assessment of current vulnerability is used as a basis to consider Kugluktuk's possible vulnerability to climatic change in the future. Current climate-related exposure-sensitivities in Kugluktuk relate primarily to subsistence harvesting and community infrastructure. Thinner and less stable ice conditions and unpredictable weather patterns are making travel and harvesting more dangerous and some community infrastructure is sensitive to permafrost melt and extreme weather events (e.g., flash floods). The ability of individuals and households to adapt to these and other climatic exposure-sensitivities is influenced by non-climatic factors that condition adaptive capacity including substance abuse, the erosion of traditional knowledge and youth suicide. These and other non-climatic factors often underpin adaptive capacity to deal with and adapt to changing conditions and must be considered in an assessment of vulnerability. This research argues that Northern communities are challenged by multiple exposure-sensitivities—beyond just those posed by climate—and effective adaptation to climate change requires consideration if not resolution of socio-economic and other issues in communities.
Feasibility of Laparoscopic Proximal Gastrectomy With Piggyback Jejunal Interposition Double-Tract Reconstruction for Proximal Gastric Cancer. A Propensity Score Matching Analysis

Background The clinical effect of laparoscopic proximal gastrectomy (LPG) with piggyback jejunal interposition double-tract reconstruction (PJIDTR) is not clear yet. The purpose of this study was to compare the efficacy of LPG with PJIDTR versus laparoscopic total gastrectomy (LTG) with Roux-en-Y reconstruction (overlap method) for proximal EGC using propensity score matching. Methods We retrospectively collected data from the patients with proximal EGC who were treated in Shanxi Cancer Hospital between January 2012 and December 2015. Propensity score was used to match LTG patients with LPG patients. The patient characteristics, clinical outcomes, nutritional indicators, reflux esophagitis incidence and overall survival were compared between the two groups. Results Of the 424 patients, 200 were excluded and 50 of the remaining patients received LPG with PJIDTR. Fifty matched LTG patients were screened. Comparison of intraoperative indicators, operative time, blood loss and number of retrieved lymphnodes between the two groups showed no statistical significance (P > 0.05). There was no statistically significant differences in first anal exhaust time, postoperative hospital stay, and early complications between the two groups (P > 0.05). The nutrition indexes at one year after surgery in the LPG group were significantly better than LTG group (P < 0.05). At one year, there were no differences in reflux symptoms (Visick score) or endoscopic esophagitis (Los Angeles Classification) between the two groups. No tumor recurrence was observed in either group. The 5-year overall survival rates of the two groups were 98% and 90%, respectively (p = 0.08). Conclusion The postoperative nutritional outcomes of LPG with PJIDTR were better than those of LTG. The incidence of reflux esophagitis, complications, and 5-year overall survival were similar between the two groups. LPG with PJIDTR may be suitable for proximal EGC.
Unraveling Sedimentary Provenance and Tectonothermal History of High‐Temperature Metapelites, Using Zircon and Monazite Chemistry: A Case Study from the Eastern Ghats Belt, India

The geochemical behavior of detrital zircon and monazite during granulite facies anatexis in metapelites from the Eastern Ghats Belt (EGB), India, is explored using U‐Pb geochronology, Hf isotopes, and trace elements. In a metapelite from the Ongole Domain, detrital zircon reequilibrated by coupled dissolution‐reprecipitation and diffusion reaction during ultrahigh‐temperature metamorphism at 1.63 Ga. The event completely reset the U‐Pb systems, but Hf isotopes and trace elements were only partially reequilibrated. Overgrowths on the altered cores date migmatization at 1.61 Ga. Monazite yields metamorphic ages similar to those of zircon. In metapelites from the Eastern Ghats Province (EGP), detrital zircon grains give 2.44–1.40‐Ga ages and metamorphic ones 1.2–0.5‐Ga ages. Metamorphic components include detrital grains reequilibrated by coupled dissolution‐reprecipitation in the presence of anatectic melt and newly crystallized overgrowths and grains. In reequilibrated domains, the U‐Pb system was completely reset, but Hf isotope compositions of precursors were often retained. The 176Hf/177Hf of most zircon scatters between 2.7‐ and 1.9‐Ga crust evolution lines, indicating late Archaean to Mesoproterozoic juvenile provenance with major crust formation between 2.7 and 1.9 Ga and only minor perturbation of the Lu‐Hf system during metamorphism. The 1.2–0.92‐ and 0.62–0.50‐Ga metamorphic populations are related to Rodinia and Gondwana assembly, respectively. The 1.63‐, 1.2–0.92‐, and 0.62–0.50‐Ga ages allow correlation of the Ongole Domain and EGP with the Rayner Complex, suggesting that East Antarctica was contiguous with Proto‐India in the Paleoproterozoic. Rifting in this terrane and sedimentation in the resulting basin deposited the EGP metapelites between 1.42 and 1.2 Ga, culminating in reamalgamation of East Antarctica with Proto‐India during Rodinia assembly. The final crustal architecture of the belt was attained during Pan‐African orogenesis when the EGB granulites were thrust westward over the cratons.
Major changes in volcano behaviour after a sector collapse: insights from Stromboli, Italy

In recent years, increasing numbers of volcanoes are being recognized as having undergone large sector collapses. How far such events can change the succeeding behaviour of the volcano is poorly known, despite the importance for natural hazards and economic applications. By analysing the last 100‐kyr geological history of Stromboli (Italy), which has involved multiple collapses, this paper illuminates the feedback effect between sector collapse and magma upwelling and emplacement. The collapsed zone of Stromboli is episodically unbuttressed, draining magma preferentially with formation of eruptive centres in the collapse amphitheatre and dyking along the collapse shoulders. After a collapse, there were no further linear eruptions across the cone on opposing middle–lower slopes, but these occurred again after rebuilding of the cone. The time‐averaged eruption rate increased immediately before the first collapse and remained higher during the succeeding period of frequent collapses.