Miracle-dz/UniFAR-FTUs huggingface dataset:
Methylen tetrahydrofolate reductase enzyme gene C677T and A1298C mutations in primigravida with first trimester missed abortion: cross-sectional study

Background: This work aimed to correlate between MTHFR C677T and A1298C genes (methylenetetrahydrofolate reductase) mutation and first trimester missed abortion in primigravida to identify pregnant ladies who need anticoagulation therapy to improve pregnancy outcome. The conducted study was a cross-sectional study. Data were collected from females recruited from EL Shatby hospital, Alexandria, Egypt. The present study was done on 40 primigravida females recruited from EL Shatby hospital. Methods: All participating women were primigravida in their first trimester with missed abortion. Blood specimens were collected from all cases involved in the study for DNA extraction and genotype analysis based on PCR and reverse hybridization. The mutations studied are the MTHFR C667T and A1298C genes. Main outcome measures: The MTHFR C667T mutations in our study is not significantly related to abortion in primigravida while MTHFR A1298C mutations prevalence were appeared significantly have a relation to abortion. Results: In the current study, the prevalence of MTHFR A1298C mutations was in 52.5% of cases, with homozygosity in 15 % of cases and heterozygosity in 37.5% of cases. However, the total prevalence of the MTHFR C667T gene mutations was 30% of cases only and all are heterozygous. Four cases were prevalent with combined thrombophilia (MTHFR C677T and A1298C) in the participating cases. Finally, the number of individuals were assessed for each of the gene mutations based on of homozygous or heterozygous. No homozygous cases were detected for MTHFR C667T gene mutation. Conclusions: In this current study, there is an association between miscarriage and thrombophilia.
Various energies of random graphs

In 1970s, Gutman introduced the concept of energy E(G) for a simple graph G, which is defined as the sum of the absolute values of the eigenvalues of G and can be used to estimate the total π-electron energy in conjugated hydrocarbons. The concept attracted lots of attention and furthermore, some other similar notions were also considered such as Laplacian energy LE(G), signless Laplacian energy LE+(G), incidence energy IE(G), distance energy DE(G) and Lapacian-energy like invariant LEL(G). Moreover, many researchers established a large number of upper and lower bounds for those invariants. But there are only a few graphs attaining the equalities of those bounds. In the present paper, however, we present exact estimates of LEL(G) , IE(G) , and DE(G) , and a tight bound of LE+(G) for almost all graphs by probabilistic and algebraic approaches.
Predictive factors of drainage volume and drain duration after the inframammary approach to nipple-areolar-complex sparing mastectomy and implant-based breast reconstruction

According to the U.S. National Cancer Institute, breast cancer is the most common cancer among women, accounting for approximately 33% of all cancers and 20% of cancer-related deaths in women in 2019 [1]. Mastectomy is the basis for the standard treatment of breast cancer. Therefore, with the increasing incidence of breast cancer, the rates of mastectomy and breast reconstruction surgery after mastectomy are also rapidly increasing [2]. Two main Yoon Soo Kim, Ho Sung Kim, Eon Ju Park, Hyo Young Kim, Hong Il Kim, Jin Hyung Park, Chang Wan Jeon , Hyung Suk Yi
A note on almost Ricci soliton and gradient almost Ricci soliton on para-Sasakian manifolds

The object of the offering exposition is to study almost Ricci soliton and gradient almost Ricci soliton in 3-dimensional para-Sasakian manifolds. At first, it is shown that if $(g, V,\lambda)$ be an almost Ricci soliton on a 3-dimensional para-Sasakian manifold $M$, then it reduces to a Ricci soliton and the soliton is expanding for $\lambda$=-2. Besides these, in this section, we prove that if $V$ is pointwise collinear with $\xi$, then $V$ is a constant multiple of $\xi$ and the manifold is of constant sectional curvature $-1$. Moreover, it is proved that if a 3-dimensional para-Sasakian manifold admits gradient almost Ricci soliton under certain conditions then either the manifold is of constant sectional curvature $-1$ or it reduces to a gradient Ricci soliton. Finally, we consider an example to justify some results of our paper.
Public Health Spending, Governance Quality and Poverty Alleviation

Poverty alleviation has become the main priority program in most developing countries. This research empirically studies the correlation between public health spending, governance quality, and poverty alleviation in developing countries. The panel data were estimated via a random-effects (RE) model and robustness check using instrumental variables (IV) (two-stage least-squares [2SLS]) and first-difference generalized method of moments (GMM) because of the endogeneity problem. The results suggest that public health spending has a significant effect on reducing the poverty rate, and that countries with better governance tend to reduce poverty than countries with poor governance. Increasing public health spending by one percentage point may reduce poverty by 0.48 percentage points in countries with good governance supposing the governance quality influences public health spending. Conversely, in countries with poor governance, the poverty headcount ratio may decline by 1.375 percentage points when public health spending increases by one percentage point.
The In vivo Trend Analysis of Kidney Function Indices and Lipid Profile of Albino Rats Administered Palm-Wine

The present study evaluated the dynamics of kidney function indices and lipid profile of albino rats after administration of palm-wine to them. The fresh palm-wine was collected from a local palm-wine tapper on daily basis and divided in to two portions. The first portion was labelled “Fresh palmwine” and administered (15 ml/kg) to group 2 and (30 ml/kg) to group 4, the second portion was allowed to ferment for additional ten hours and labelled “prolonged-fermented palm-wine” and administered (15 ml/kg) to group 3 and (30 ml/kg) to group 5. Group one served as the control and received distilled water, all for 28 days. Each group was randomly allocated four rats. Results (mmol/ml) revealed a significantly(p<0.05) lower concentration of urea (10.21±0.40), higher creatinine (0.37±0.17), K+ (4.06±0.06) and Cl (86.12±4.61) in group 2 when compared to the control; 11.035±. 110, 0.395±0.06, 3.945±. 064, 80.090±0.25 respectively. In group 3, the concentrations of urea (11.70±0.35), creatinine (0.42±0.12) and Cl (88.57±0.50) were significantly (p<0.05) higher when compared to the control. Na (120.09±10.40) was significantly (p<0.05) higher in group 4 when compared to the control (100.065±0.75). TAG (in mg/dL) (2.18±0.10) was significantly(p<0.05) higher in group 2 compared to control (1.96±0.023). T. cholesterol (3.125±0.27) and LDL-C (1.64±0.47) were significantly (p<0.05) lower in group 3 compared to the control; 1.99±0.052, respectively with significantly(p<0.05) elevated HDL (1.11±0.22) compared to control (0.840±0.092). TAG (2.190±0.25) and HDL-C (1.15±0.23) increased significantly(p<0.05) while LDL-C (1.58±0.14) decreased significantly (p<0.05) in group 4 compared to control; 1.960±0.023, 0.840±0.092, 1.985±0.052 respectively. T. cholesterol (2.93±0.08) and LDLC (1.56±0.03) decreased significantly(p<0.05) with significant(p<0.05) increase in HDL-C (0.99±0.10) in group 5 compared to the control. Fresh and prolonged-fermented palm-wine may adversely affect kidney function indices and lipid profile.
Glomerular hyperfi ltration in Yemeni children with sickle cell disease

Methods: This study aimed to determine the prevalence and correlates of GH among children (≤ 16 years) with sickle cell disease (SCD) at their steady state, recruited over 6 months at the Pediatric Outpatient Clinic in Al-Sadaqa General Teaching Hospital, Aden, Yemen. Glomerular fi ltration rate (eGFR) was estimated using the Schwartz formula. Data on clinical history, anthropometry, blood pressure (BP) and laboratory investigations were collected.
IMPACT OF THE INTERACTION BETWEEN AMINO ACIDS (AA), NAPHTHALENE ACETIC ACID (NAA) AND NAPHTHALENE ACETAMIDE (NAD) ON SANTA ROSA PLUM FRUIT ABSCISSION,

o decrease fruit abscission, increase yield and improve fruit quality of Santa Rosa (Prunus salicina Lindl.) plum; amino acids (AA), naphthalene acetic acid (NAA) and naphthalene acetamide (NAD) and combination of them were applied at different concentrations ; at full bloom stage and one week after fruit setting stage during 2015 and 2016, in a private orchard at Ashmoun, Monofia governorate, Egypt. Results indicated that fruit set percentage significantly increased by all AA, NAA and NAD treatments compared to the control. AA 0.25 ml/L+NAA 10 ppm + NAD at 10 ppm recorded the highest significant fruit set percentage and the lowest significant fruit drop percentage and gave the maximum yield (6264 Kg/ tree). With regard to fruit quality, the same treatment increased fruit weight, length, diameter, firmness, pulp/stone ratio and total soluble solids content, but decreased titratable acidity in Santa Rosa plum. In addition, total carbohydrates, total nitrogen and C/N ratio in leaves were higher in treated trees than the control ones. Anatomical studies indicated that inactive embryo development after ovule fertilization may be the major cause of young fruits drop observed in ‘Santa Rosa’ plum trees. Furthermore, there was a relationship between physiological fruit drop which occured from the middle of Growth Stage 2 to the beginning of Growth Stage 3, and seed development which contain inactive endosperm. From this study, it can be concluded that combination of AA, NAA and NAD increased fruit set, reduced fruit abscission, enhanced C/N ratio in leaves and improved fruit yield and quality of Santa Rosa plum. Thus, it may be recommended to spray AA 0.25 ml/l +NAA 10 ppm + NAD 10 ppm under similar conditions.
Acoustic Invariant Approach to Speech Sound Analysis for Brand New Speech Recognition Systems (Ukrainian and English)

: On the basis of acoustic invariant speech analysis (AISA), the permanent spectral characteristics of the Ukrainian vowels are obtained for various ways of pronunciation including ordinary speech, whisper and changing tone. It is shown that the lowest phonemic frequencies due to vocal fold oscillations or to Helmholtz resonance are not associated with persistent sound features. It is conjectured that the only phonemic invariant is the ratio between formant frequencies, not their absolute values. This analysis is complemented by the computer sound synthesis. We show also that the acoustic invariants of the Ukrainian sound [i] are close to that of English [I]. The results obtained may be useful for specialists in the field of experimental phonetics and speech modelling.
The Use of Benzodiazepines Among Brazilian Women: An Integrative Literature Review

The prolonged use of benzodiazepines among women has been a recurring issue in health services. Hence, this study aimed to conduct an integrative literature review to identify the profile of Brazilian women regularly using benzodiazepines. The SciELO, PePSIC, and BVS-LILACS databases were searched, and 86 articles were identified by combining the keywords “mulher(es) AND benzodiazepinico(s)”, but only 11 papers met the inclusion criteria. Data revealed a higher concentration of women aged between 40 and 60 years old who used benzodiazepines for between one month and 37 years to treat insomnia, anxiety, headaches, and sadness. Benzodiazepines appear as a resource to escape problems and are usually prescribed by general practitioners without taking into account these women’s social issues that involve role overload, among other factors.
Earliest hepatitis B virus-hepatocyte genome integration: sites, mechanism, and significance in carcinogenesis

Hepatocellular carcinoma (HCC) is the fifth most widespread cancer responsible for one fourth of cancer-related deaths globally. Persistent infection with hepatitis B virus (HBV) remains the main cause of HCC summing up to 50% of its causative etiology. Our recent studies, supported by findings from others, uncovered that HBV and its close relative woodchuck hepatitis virus (WHV) integrate into hepatocyte genome almost immediately, hence in minutes after infection. Retrotransposons and genes with translocation potential were found to be frequent sites of HBV insertions, suggesting a mechanism of HBV DNA spread across liver genome from the earliest stages after virus invasion. Many other genes were identified as the sites of early hepadnavirus merges in human hepatocyte-like lines infected de novo with HBV and in natural woodchuck WHV infection model. It was uncovered that head-to-tail joins (HTJs) prevail among the earliest virus-host fusions, implying their formation via the non-homologous-end-joining (NHEJ) pathway. Overlapping homologous junctions resulting from the micro-homology-mediated-overlapping-joining (MHMOJ) were rarely detected. Formation of the initial HTJs coincided with strong induction of reactive oxygen species (ROS) and transient appearance of inducible nitric oxide (iNOS). This was accompanied by cell DNA damage and activation of the poly(ADP-ribose) polymerase 1 (PARP1)-mediated host DNA repair machinery, which may explain predominant HTJ format of the first virushost fusions. Identification of initial integration sites and resulting alterations in hepatocyte phenotype may pave a way to discovery of reliable markers of HBV-triggered HCC, including HCC resulting from occult HBV infection. Our research strongly argues that HBV is an ultimate human carcinogen capable of initiation of a pro-oncogenic process immediately after first contact with a susceptible host. Received: First Decision: Revised: Accepted: Published: Science Editor: Copy Editor: Production Editor: Jing Yu Page 2 of 20 Chauhan et al. Hepatoma Res 2021;7:20 I http://dx.doi. org/10.20517/2394-5079.2020. 136
Neuroprotective activity of Garcinia morella desr against monosodium glutamate-induced neurotoxicity in rats

The aim of the present study is to evaluate the neuroprotective effect of methanol extract of Garcinia morella Desr leaves in monosodium glutamate (MSG) induced neurotoxicity in rats. The MSG 2 g/kg, i.p. was used to induce the neurotoxicity. The rats were administrated with methanol extract of Garcinia morella Desr leaves (MEGM) 200 and 400 mg/kg, p.o. and Dextromethorphan 30 mg/kg, p.o. after 1 h injection of MSG. The animals were evaluated for its behavioural factors such as muscle grip and locomotor activity. At the end of the study, the antioxidant enzymes levels, neurotransmitter levels, TNFα, ß-amyloid and mineral levels were estimated in brain homogenate. The MEGM treated group shows signi icant improvement of behavioural and locomotor activity and muscle strength against MSG induced neurotoxicity. The glutathione, SOD, catalase and total protein levels were signi icantly increased in MEGM treated group. However, signi icant reduction within the level of varied neurotransmitters like AChE, Dopamine, TNFα, ß-amyloid were observed on treatment with MEGM extract. Further, MEGM also signi icantly decrease the MSG induced toxicity through declined levels of Ca and Na with increased levels of K. In conclusion, the present study suggests that the MEGM has signi icant neuroprotective activity against MSG induced neurotoxic rats.
Critical roles for the co-repressor, Rcor1, in lineage determination

1 CHAPTER 1: Introduction . 3 1.1 Transcriptional regulation and lineage determination . 4 1.1.1 Histone modifications and transcriptional regulation . 4 1.1.2 Transcriptional cofactors and the REST corepressor (Rcor1) complex . 8 1.2 Lineage differentiation in hematopoietic system . 14 1.2. 1 Erythropoiesis . 22 1.2. 2 Myelopoiesis . 25 1.2. 3 Megakaryoctye differentiation . 31 1.3 Transcriptional regulation in hematopoiesis . 31 1.3. 1 Transcriptional regulation of early hematopoietic development . 34 1.3. 2 Transcriptional regulation of erythropoiesis and megakaryocyte differentiation . 34 1.3. 3 Transcriptional regulation of myelopoiesis . 36 1.3. 4 Principles in transcriptional regulation of hematopoiesis . 39 1.4 Significance of studying Rcor1 function in hematopoiesis . 40 CHAPTER 2: Preliminary studies of Rcor1 function in nervous system . 43 Introduction . 44 Materials and methods . 45 Results . 51 Discussion . 57 ii Acknowledgements . 60 Figures and legends . 61 CHAPTER 3: The co-repressor Rcor1 is essential for murine erythropoiesis . 73 Introduction . 74 Materials and methods . 75 Results . 86 Discussion . 95 Acknowledgements . 98 Figures and legends . 99 CHAPTER 4: Rcor1 deficiency disrupts myeloerythroid lineage differentiation and causes severe myelodysplasia in mice . 123 Introduction . 124 Materials and methods . 126 Results . 129 Discussion . 137 Acknowledgements . 140 Figures and legends . 141 CHAPTER 5: Concluding remarks and further direction . 154 Unraveling transcription networks . 155 How does Gfi1b/Rcor1/LSD1 function fit into the overall transcriptional regulation of erythropoiesis? 157 Does Rcor1 have a role in the pathogenesis of MDS? 160
The Evidence Supporting a Systematic Approach to the Care of the Injured Patient:From Prevention to Rehabilitation

INTRODUCTION Trauma is the leading cause of death for individuals under 45 years of age in the Western world and remains the fourth leading cause of death for all ages combined (1,2,3,4). Approximately 0.9 million people worldwide die secondarily to injury (8% of all deaths) (5). It is also a major cause of morbidity in both the short and long-term (6). Furthermore, injury is a leading cause of disability, potential years of life lost and a major contributor to overall health care costs (7,8,9). It is estimated that injury causes 36 life-years lost per death compared to 16 life-years for cancer and 12 years for heart disease and stroke combined (10). In 1994, 8,687 people died following accidents in Canada (1). Approximately four times as many patients suffer severe disability related to accidents each year. The cost of acute medical care for injured patients is in excess of $16 billion per annum (11). This represents the second largest source of medical expenditures in the United States. In addition to the health dollars spent on the acute care of injured patients, an additional $150 billion US are required to cover the annual cost due to death, disability, and lost wages and taxes (9). From a health-economic perspective, the cost of trauma and its consequences makes the elucidation of evidence-based practices paramount. Trauma care systems have been shown to significantly decrease medical care costs. It is estimated that by extending trauma care systems throughout the entire United States, annual medical care payments could be lowered by $3.2 billion (12). If productivity costs due to premature death are taken into account, the total savings could total $10.3 billion.
Evaluation of asphaltene adsorption on minerals of dolomite and sandstone formations in two and three-phase systems

Asphaltene adsorption on reservoir rock minerals causes wettability alteration and pore plugging which subsequently reduces crude oil production. Also, it has a negative effect on the efﬁciency of production and enhanced oil recovery operations. In this study, the adsorption of extracted asphaltenes of two samples of Iranian oil ﬁelds on dolomite, quartz, and magnetite was investigated in two-and three-phase systems in both static and dynamic ﬂow modes. Mineral adsorbents were analyzed by Brunauer–Emmett–Teller and X-ray ﬂuorescence methods. Also, several laboratory tests including elemental analysis, ﬁeld emission scanning electron microscopy, and Fourier transform infrared spectroscopy were carried out to characterize asphaltenes. The results showed that in addition to the effect of known parameters such as asphaltenes concentration and speciﬁc surface area of the solid phase, the water phase also affects the amount of asphaltenes adsorption. The adsorption amount of asphaltenes increases with increasing the speciﬁc surface area of adsorbent (decreasing particle size) and increasing the initial concentration of asphaltenes, and decreases with the addition of water to the two-phase system. The static adsorption amount of asphaltenes in a two-phase system can be up to 90% higher than the adsorption amount in a three-phase system. Doubling the ﬂuid ﬂow rate in dynamic adsorption signiﬁcantly (by about 20%) reduces the asphaltenes adsorption, which could be a sign of physical adsorption of asphaltenes on adsorbents. The structure and elemental composition of asphaltenes also have a signiﬁcant effect on asphaltenes adsorption. The asphaltene sample, which had a more aromatic nature and high nitrogen content, had higher adsorption on reservoir rock minerals. Finally, ﬁtting the adsorption equilibrium models with experimental data reveals that the adsorption isotherm model depends on the type and particle size of the adsorbents and the concentration and type of asphaltenes. Cited as : Mohammadi, M.R. , Bahmaninia, H. , Ansari, S. , Hemmati-Sarapardeh, A. , Norouzi-Apourvari, S. , Schafﬁe, M. , Ranjbar, M. Evaluation of asphaltene adsorption on minerals of dolomite and sandstone formations in two and three-phase systems. Advances in Geo-Energy Research, 2021, 5(1), 39-52, doi: 10.46690/ager.2021. 01.05
Structural Analysis of the Correlation between Occupational Stress and Quality of life in University Administrators Using a PLS Approach

Article Info Background: University administrators play a key role in providing educational services to students and faculty members. This study aims to explain occupational stress (OS) in university administrators based on health-related quality of life (QoL) using a PLS approach. Materials and Methods: The statistical population of this correlational study included all 70 managers in the field of education at Islamic Azad University of Tabriz in 2020. Based on Krejcie and Morgan's sampling table, 60 people were selected by simple random sampling. Data were collected using the revised OS questionnaire of the United Kingdom Health Safety Executive (2004) and the World Health Organization's QoL (WHOQOLBREF) questionnaire. The questionnaire of QoL included dimensions of mental health, physical health, social health, environmental health, and general health. OS questionnaire is not categorized into components. Composite reliability was 0.96 for the OS questionnaire and 0.93 for the QoL questionnaire. To test the hypotheses, structural equation modelling was employed with SPSS and PLS software. Results: The results showed a significant negative association between QoL and its dimensions, including general health, physical health, mental health, environmental health, and social health with OS (P < 0.01). In addition, OS could be predicted only based on the dimensions of physical health (P = 0.02) and environmental health (P = 0.01). Conclusion: Paying attention to QoL in university administrators could reduce their OS and promote positive working consequences at the university.