Miracle-dz/UniFAR-FTUs huggingface dataset:
An Acute Bout of Self-Myofascial Release Does Not Affect Drop Jump Performance despite an Increase in Ankle Range of Motion

This study examined the acute effects of self-myofascial release plus dynamic warm up versus dynamic warm up alone on ankle range of motion and drop jump performance. Twenty-five recreationally active participants (male: 16, female: 9) were randomly assigned into a foam rolling (FR) or a dynamic warm up group (CON) (age: 22.8 ± 3.9 years, body mass 75.9 ± 13.2 kg, stretch stature: 174.1 ± 10.1 cm). In a randomised crossover design, each participant completed two experimental sessions that were separated by seven days. Ankle range of movement was assessed while using a weight-bearing lunge test and drop jump performance was recorded via bilateral force plates. Following a 5 min cycle, the foam rolling group undertook self-myofascial release to the lower limb and thoracic/lumbar regions, followed by a dynamic warm up. The control group undertook the same initial warm up plus the dynamic exercises. The level of significance was set at p ≤ 0.05. There was a significant increase (p < 0.001) in ankle range of motion immediately after the warm up for both groups (pre CON: 37.5 ± 5.31, post CON: 39.8 ± 5.76; pre FR 38.7 ± 7, post FR: 40.3 ± 7.3 deg). No significant difference was found between the conditions (p > 0.05). There were no significant differences for any indices of jump performance (p > 0.05). Based on these results, foam rolling plus dynamic exercises does not appear to impair or enhance drop jump performance, despite the increases in ankle range of movement.
The changing physical and ecological meanings of North Pacific Ocean climate indices

Significance The PDO and NPGO indices are important tools for summarizing and understanding climate variability. As with other climate indices, the PDO and NPGO are assumed to have stable relationships with the climate variables they synthesize. We found that a late-1980s North Pacific climate shift resulted in changing correlations between large-scale climate patterns and the PDO and NPGO, and widespread weakening in relationships between the PDO/NPGO and regional physical and ecological processes. These findings suggest that understanding based on observed correlations with PDO/NPGO variability may have limited utility when applied to different time periods. Time dependence in correlations with these static climate indices may accelerate in the future, as climate change is expected to further shuffle relationships among climate variables. Climate change is likely to change the relationships between commonly used climate indices and underlying patterns of climate variability, but this complexity is rarely considered in studies using climate indices. Here, we show that the physical and ecological conditions mapping onto the Pacific Decadal Oscillation (PDO) index and North Pacific Gyre Oscillation (NPGO) index have changed over multidecadal timescales. These changes apparently began around a 1988/1989 North Pacific climate shift that was marked by abrupt northeast Pacific warming, declining temporal variance in the Aleutian Low (a leading atmospheric driver of the PDO), and increasing correlation between the PDO and NPGO patterns. Sea level pressure and surface temperature patterns associated with each climate index changed after 1988/1989, indicating that identical index values reflect different states of basin-scale climate over time. The PDO and NPGO also show time-dependent skill as indices of regional northeast Pacific ecosystem variability. Since the late 1980s, both indices have become less relevant to physical–ecological variability in regional ecosystems from the Bering Sea to the southern California Current. Users of these climate indices should be aware of nonstationary relationships with underlying climate variability within the historical record, and the potential for further nonstationarity with ongoing climate change.
The Epidemiological Investigation of Patients with HIV/AIDS in Bandar Abbas Behavioral Disorders Counseling Center During 2005-2015

Background and Objectives: The epidemic Acquired Immune Deficiency Syndrome (AIDS) and Human Immunodeficiency Virus (HIV) is the most serious public health threat in the world now. HIV affects the human immune system and causes damage of catching opportunistic infections. The epidemic pattern of the disease is strongly dependent on high risk behaviors as a major factor in the community. The aim of this study was epidemiological investigation of HIV/AIDS patients in Bandar Abbas Behavioral Disorders Counseling Center during 2005-2015. Materials and Methods: This cross-sectional study was conducted in 2016 on 426 HIV-positive patients aged 18 years old and older who were under the care of the Counseling Center for Behavioral Diseases in Bandar Abbas during 2005 to 2015. Demographic and clinical information were extracted from the patients records by the staff of the consulting center and was recorded in the researcher made checklist. Data were analyzed using chi-square and Fisher's exact tests. Results: The average and standard deviation of age of patients was 36.30±8.02 years, most of them were in the age group of 18-44 years old ,and 73% (311 cases) were male. Twenty three percent (92 cases) of patients were in AIDS stage. Most of the patients were infected through drug injection abuse (62.4%) and sexual intercourse (42.5%). Conclusion: The results of the current study showed that most of the patients have been infected through injecting drug use. Therefore, desirable education and proper counseling are effective to prevent and control the risk factors and reduce the incidence of the disease in the community. Key words: Epidemiologic study, Acquired immunodeficiency syndrome, HIV, Bandar Abbas Funding: This study did not have any funds. Conflict of interest: None declared. Ethical approval: The Ethics Committee of Rafsanjan University of Medical Sciences approved the study, (IR.RUMS.REC.1395.61). How to cite this article: Yaghoobi H, Ahmadiniya H, Shabani Z, Vazirinejad R, Zolfizadeh F, Rezaeian M. Epidemiological Investigation of Patients with HIV/AIDS in Bandar Abbas Behavioral Disorders Counseling Center During 2005-2015. J Rafsanjan Univ Med Sci 2018; 16(10): 969-82. [Farsi]
Different Pulp Dressing Materials for the Pulpotomy of Primary Teeth: A Systematic Review of the Literature

Background: Pulpotomy of primary teeth provides favorable clinical results over time; however, to date, there is still not a consensus on an ideal pulp dressing material. Therefore, the aim of the present systematic review was to compare pulpotomy agents to establish a preferred material to use. Methods: After raising a PICO question, the PRISMA guideline was adopted to carry out an electronic search through the MEDLINE database to identify comparative studies on several pulp dressing agents, published up to October 2019. Results: The search resulted in 4274 records; after exclusion, a total of 41 papers were included in the present review. Mineral trioxide aggregate (MTA), Biodentine and ferric sulphate yielded good clinical results over time and might be safely used in the pulpotomies of primary molars. Among agents, MTA seemed to be the material of choice. On the contrary, calcium hydroxide showed the worst clinical performance. Although clinically successful, formocreosol should be replaced by other materials, due to its potential cytotoxicity and carcinogenicity. Conclusion: MTA seemed to be the gold standard material in the pulpotomy of primary teeth. Promising results were also provided by calcium silicate-based cements. Further randomized clinical trials (RCTs) with adequate sample sizes and long follow-ups are encouraged to support these outcomes.
THE INVESTIGATION OF THE ASSOCIATION BETWEEN SYSTEMIC DISEASES AND PERIODONTITIS IN SUBJECTS REFERRED PERIODONTOLOGY CLINIC

Aim: The aims of this study were to determine the prevalence of systemic diseases in subjects referred toperiodontology clinic, to evaluate whether there is a difference in risk of systemic disease existence betweensubjects with and without periodontitis and to assess whether there is any association between periodontitisand systemic diseases in this population. Material and methods: The 2737 medical and dental history formsof the subjects referred Periodontology Clinic of Suleyman Demirel University Faculty of Dentistry whichwere archived in years 2004-2005 were assessed. Results: A total of 1887 patients were periodontitis while850 patients were not based on the anamnesis forms. The number of patients with systemic disease was 846(30.9%). The most common systemic disease was cardiovascular disease (12.1%) followed by endocrinediseases (7.2%), rheumatologic diseases (4.3%), infectious diseases (4.3%), hematologic disorders (3%),pulmonary diseases (2.9%), and dermatologic diseases (0.5%). There was significant difference regardingthe presence of systemic diseases between the subjects with and without periodontitis (p<0.001). Periodontitiswas found a risk factor for systemic disease existence with an odds ratio of 1.775 in logistic regressionanalysis. Conclusion: Our findings suggest that periodontitis patients had more systemic disease comparedwith subjects without periodontitis. Periodontitis may be a risk factor for systemic disease
Agents of change: Understanding the therapeutic processes associated with the helpfulness of therapy for mental health problems with relational agent MYLO

Objective To understand the therapeutic processes associated with the helpfulness of an online relational agent intervention, Manage Your Life Online (MYLO). Methods Fifteen participants experiencing a mental health related problem used Manage Your Life Online for 2 weeks. At follow-up, the participants each identified two helpful and two unhelpful questions posed by Manage Your Life Online within a single intervention session. Qualitative interviews were conducted and analyzed using thematic and content analysis to gain insight into the process of therapy with Manage Your Life Online. Results MYLO appeared acceptable to participants with a range of presenting problems. Questions enabling free expression, increased awareness, and new insights were key to a helpful intervention. The findings were consistent with the core processes of therapeutic change, according to Perceptual Control Theory, a unifying theory of psychological distress. Questions that elicited intense emotions, were repetitive, confusing, or inappropriate were identified as unhelpful and were associated with disengagement or loss of faith in Manage Your Life Online. Conclusions The findings provide insight into the likely core therapy processes experienced as helpful or hindering and outlines further ways to optimize acceptability of Manage Your Life Online.
TRPC1 participates in the HSV-1 infection process by facilitating viral entry

TRPC1 channel facilitates virus infection. Mammalian transient receptor potential (TRP) channels are major components of Ca2+ signaling pathways and control a diversity of physiological functions. Here, we report a specific role for TRPC1 in the entry of herpes simplex virus type 1 (HSV-1) into cells. HSV-1–induced Ca2+ release and entry were dependent on Orai1, STIM1, and TRPC1. Inhibition of Ca2+ entry or knockdown of these proteins attenuated viral entry and infection. HSV-1 glycoprotein D interacted with the third ectodomain of TRPC1, and this interaction facilitated viral entry. Knockout of TRPC1 attenuated HSV-1–induced ocular abnormality and morbidity in vivo in TRPC1−/− mice. There was a strong correlation between HSV-1 infection and plasma membrane localization of TRPC1 in epithelial cells within oral lesions in buccal biopsies from HSV-1–infected patients. Together, our findings demonstrate a critical role for TRPC1 in HSV-1 infection and suggest the channel as a potential target for anti-HSV therapy.
Movement of Rhagoletis mendax (Diptera: Tephritidae) in Fruit-Bearing Wild Blueberry Fields. Part II

Abstract During dispersal into fruit-bearing wild blueberry fields, blueberry maggot flies were highly active during all daylight hours as revealed by trap captures, although in one trial afternoon activity was greater than morning activity. Flies were not captured in traps at night, although observations in growth chambers showed that their activity at night, measured as displacement of position, was equal to daylight conditions. Flies were shown to fly at low altitude, just above the crop canopy, and screen fencing was shown to be effective at reducing colonization of plots, presumably due to their low height during flight. Over a 4-yr mark–capture study, colonization rate was shown to be low at 9.7 m/d, although a separate 2010 study showed higher rates at 14.1 and 28.0 m/d. Movement was shown to be nondirectional or random in the field, but a constrained random walk exhibiting direction into the field. Weed cover and high fruit density were associated with higher fly relative abundance, suggesting these field characteristics served as attractors slowing colonization rate into a field. Transect trap studies showed the temporal and spatial pattern of fly colonization into commercial wild blueberry fields, one of a slow wave that penetrates into the field interior as the season progresses. There is also an increase in fly abundance within-field edges and adjacent forest. The ‘stacking’ of flies along a field edge and slow movement rate into a field was shown through simulation to be a result of nondirectional short-distance dispersal of flies.
Leptospira interrogans and Leptospira kirschneri are the dominant Leptospira species causing human leptospirosis in Central Malaysia

Background Leptospirosis, commonly known as rat-urine disease, is a global but endemic zoonotic disease in the tropics. Despite the historical report of leptospirosis in Malaysia, the information on human-infecting species is limited. Determining the circulating species is important to understand its epidemiology, thereby to strategize appropriate control measures through public health interventions, diagnostics, therapeutics and vaccine development. Methodology/Principle findings We investigated the human-infecting Leptospira species in blood and serum samples collected from clinically suspected leptospirosis patients admitted to three tertiary care hospitals in Malaysia. From a total of 165 patients, 92 (56%) were confirmed cases of leptospirosis through Microscopic Agglutination Test (MAT) (n = 43; 47%), Polymerase Chain Reaction (PCR) (n = 63; 68%) or both MAT and PCR (n = 14; 15%). The infecting Leptospira spp. , determined by partial 16S rDNA (rrs) gene sequencing revealed two pathogenic species namely Leptospira interrogans (n = 44, 70%) and Leptospira kirschneri (n = 17, 27%) and one intermediate species Leptospira wolffii (n = 2, 3%). Multilocus sequence typing (MLST) identified an isolate of L. interrogans as a novel sequence type (ST 265), suggesting that this human-infecting strain has a unique genetic profile different from similar species isolated from rodents so far. Conclusions/Significance Leptospira interrogans and Leptospira kirschneri were identified as the dominant Leptospira species causing human leptospirosis in Central Malaysia. The existence of novel clinically important ST 265 (infecting human), that is different from rodent L. interrogans strains cautions reservoir(s) of these Leptospira lineages are yet to be identified.
Gender differences in attention to pain body postures in a social context: a novel use of the bodies in the crowd task.

Pain signals the presence of potential harm, captures attention, and can inhibit performance on concurrent tasks. What is less well known, however, is whether such attentional capture also occurs in a wider social context, such as when observing people in pain. In order to explore this possibility, we adopted a novel social-cue detection methodology: the bodies-in-the-crowd task. Two experiments are reported that consider whether nonverbal cues of pain, happiness and anger as expressed through body postures would capture and hold attention. Both experiments recruited 40 (20 male, 20 female) pain-free individuals. Overall, results show that pain postures do not capture attention any more than happiness or anger postures, but disengagement from pain postures was significantly slower across both studies. Gender differences were also found, and were more likely to be found, when crowds comprised both men and women. Male pain postures were more likely to capture attention. Whilst female observers had faster target detection speed, and were quicker to disengage from distractors. They also showed slower disengagement from female expressions overall. Male observers showed no variation based on target or distractor gender. Implications and potential directions for future research are discussed.
Review of common causes of abortion in dairy cattlein Ethiopia

Abortion in dairy cattle may be caused by infectious and non-infectious agents. Infectious causes of abortion in dairy cattle include brucellosis, leptospirosis, listeriosis, Q fever, bovine viral diarrhea, mycotic abortion and neosporosis. Non-infectious causes of abortion in dairy cattle are genetic and non-genetic disorder. Risk factors associated with abortion in dairy cattle are genetic, environmental, management, geographical factors and infectious factors. Abortion in dairy cows brings about breeding and productive damages. Abortions cause significant economic loss to dairy farm. These losses can be attributed to loss of replacement calves, reduced milk production, costs of treatment, feeding of animals and premature culling of productive cows and heifers. Diagnosis of bovine abortion includes the collection of a complete history of the case and relevant epidemiological data and collected sample for analysis. However, determining the cause of bovine abortion is difficult as abortions are caused by numerous infectious and noninfectious factors. Status of abortion and breeds affected by abortion in Ethiopia were also reviewed. Key words: Causes, abortion, dairy cattle, Ethiopia.
DNA sequencing, genomes and genetic markers of microbes on fruits and vegetables

The development of DNA sequencing technology has provided an effective method for studying foodborne and phytopathogenic microorganisms on fruits and vegetables (F & V). DNA sequencing has successfully proceeded through three generations, including the tens of operating platforms. These advances have significantly promoted microbial whole‐genome sequencing (WGS) and DNA polymorphism research. Based on genomic and regional polymorphisms, genetic markers have been widely obtained. These molecular markers are used as targets for PCR or chip analyses to detect microbes at the genetic level. Furthermore, metagenomic analyses conducted by sequencing the hypervariable regions of ribosomal DNA (rDNA) have revealed comprehensive microbial communities in various studies on F & V. This review highlights the basic principles of three generations of DNA sequencing, and summarizes the WGS studies of and available DNA markers for major bacterial foodborne pathogens and phytopathogenic fungi found on F & V. In addition, rDNA sequencing‐based bacterial and fungal metagenomics are summarized under three topics. These findings deepen the understanding of DNA sequencing and its application in studies of foodborne and phytopathogenic microbes and shed light on strategies for the monitoring of F & V microbes and quality control.
Prognostic and predictive impact of genetic markers in patients with CLL treated with obinutuzumab and venetoclax.

Genetic parameters are established prognostic factors in chronic lymphocytic leukemia (CLL) treated with chemoimmunotherapy but less well studied with novel compounds. We assessed IGHV mutation status, common genomic aberrations and gene mutations in 421 untreated patients within the CLL14 trial (NCT02242942) comparing obinutuzumab+chlorambucil (GClb) vs. obinutuzumab+venetoclax (VenG). The incidences of genomic aberrations considering the hierarchical model were del(17p) 7%, del(11q) 18%, +(12) 18% and del(13q) 35%, while IGHV was unmutated in 60% of patients. NOTCH1 mutations were most common (23%), followed by SF3B1 (16%), ATM (13%) and TP53 (10%). While the overall response rate (ORR) for GClb was lower in patients with del(17p), del(11q), mutated TP53, ATM and BIRC3, none of these parameters reduced complete remission (CR) and ORR with VenG. At a median follow-up of 28 months, del(17p) and mutated TP53 were the only abnormalities with impact on PFS for both treatment arms, GClb (HR 4.6, p<0.01, HR 2.7, p<0.01) and VenG (HR 4.4, p<0.01, HR 3.1 p<0.01). No other factors affected outcome with VenG, while for GClb del(11q), BIRC3, NOTCH1 and unmutated IGHV associated with shorter PFS. Multivariable analysis identified del(17p), del(11q), unmutated IGHV and mutated TP53, BIRC3 and SF3B1 as independent prognostic factors for PFS with GClb, while for VenG only del(17p) was significant. VenG was superior to GClb across most genetic subgroups. Especially patients with adverse genetic markers had the strongest benefit from VenG, particularly subjects with unmutated IGHV, which was identified as a predictive factor in a multivariable treatment-interaction analysis.
Longitudinal Description of Gonadal Function in Sickle-cell Patients Treated With Hematopoietic Stem Cell Transplant Using Alkylator-based Conditioning Regimens

Objectives: This study describes the hormone profiles for gonadal late effects after alkylator-based hematopoietic stem cell transplant (HSCT) regimens used for sickle-cell disease (SCD). Methods: This is a retrospective chart review of subjects followed in the post-HSCT clinic for sickle-cell disease. Patient demographics, pubertal development, characteristics of pre-HSCT disease severity, treatment before HSCT, conditioning regimens, presence of graft versus host disease and follicle-stimulating hormone, anti-Müllerian hormone (AMH), luteinizing hormone and testosterone were abstracted from the medical record. Results: Forty subjects (24 female individuals) with SCD were 9 (±4.3) years old at HSCT and 7.9 years (±5.6) from HSCT. At the time of transplant, 8% of female individuals and no male individuals were pubertal and 58% of female individuals and 38% of male individuals had been treated with hydroxyurea. Post-HSCT, all of the female individuals had diminished ovarian reserve on the basis of low AMH values and 10 of the pubertal female individuals (71%) had premature ovarian insufficiency defined as follicle-stimulating hormone >40 mIU/mL ×2. There was no ovarian recovery and AMH remained very low or undetectable up to 13 years post-HSCT. In male individuals, luteinizing hormone and testosterone levels were normal for age. Conclusions: Post-HSCT for SCD, all female individuals had diminished ovarian reserve and most female individuals had POI, whereas male individuals had normal testosterone hormone production.