Miracle-dz/UniFAR-FTUs huggingface dataset:
A CROSS-SECTIONAL STUDY ON EFFECT OF HIGH BODY MASS INDEX ON HEART RATE IN ADULTS IN SRI GANGANAGAR

Background: Both overweight and obesity in adults are linked to lower heart rate variability (HRV). Heart rate variability (HRV) is a non-invasive indicator of autonomic cardiac regulation that has been associated to a number of clinical diseases. The present study objective was to find out the correlation between heart rate and body mass index in the study participants. Materials and Methods: The study was conducted in Dr SS Tantia Medical College, hospital and research center. 50 adult obese participants with BMI >30 Kg/m2 and 50 Normal weighted participants with BMI in the range of BMI 18.5–24.99 Kg/m2 as controls were included in the study. A simple method was used to evaluate the parameters. Data were recorded and entered into MS Excel and analyzed using MS Excel and SPSS (Statistical Package for Social Sciences). Result: RR Interval (SD), RR interval difference (RMS), RR interval difference when compared to the normal weight group were significantly lower in the obese group (p value <0.05). Conclusion: It is important to study the effect of High BMI on HRV for effective control of cardiovascular disorders.
ASSOCIATION OF SERUM VITAMIN-D AND CALCIUM LEVELS WITH THE SEVERITY OF HIP FRAGILITY FRACTURES IN THE ELDERLY PATIENTS: A PROSPECTIVE STUDY

Background: Due to changes in bone mass, architecture, and material properties, older people with fragility fractures have markedly lower bone strength. These fractures result from low-energy injuries in elderly people. Hip fractures in elderly people result from low-energy injuries and have been linked to vitamin D insufficiency as a separate risk factor. It is also linked to poor muscle function, muscle weakness, an increased risk of falls, inadequate rehabilitation post-injury, and a higher chance of refracture in these patients. Understanding the links between vitamin D, serum calcium, and the severity of hip fractures can help to personalize preventative measures, enhance prognosis, plan treatment, and deliver differently tailored therapies. There have been no studies to see for an association of serum calcium and vitamin D with the severity of fragility hip fractures. Our study aims to analyze the baseline differences of calcium and vitamin D levels in patients with different types of hip fractures and their severity. Objectives: a) To determine the serum calcium levels and serum Vitamin-D levels in elderly patients having fragility hip fractures at B.L. D.E. (deemed to be university) Shri B. M. Patil Medical College, Hospital & research center, Vijayapura, Karnataka. b) To categorize hip fractures based on their type and further subclassify them based on their severity. c) To correlate the calcium and Vitamin-D levels in elderly patients with severity of fractures of hip which are further classified based on age and gender
COMPARATIVE ASSESSMENT OF EFFICACY OF CONTRAST ENHANCED COMPUTED TOMOGRAPHY AND ULTRASONOGRAPHY IN EVALUATION OF RIGHT LOWER QUADRANT ABDOMINAL PAIN

Background: Right lower quadrant (RLQ) abdominal pain occurs directly above the right inguinal ligament and can last for few hours to months. The most common causes of RLQ pain are conditions that affect the underlying intra-abdominal organs, such as infection, perforation, inflammation, blockage, neoplasia, vascular events, etc. Contrast enhanced computed tomography (CECT) can and ultrasonography (USG) are the most common diagnostic technique adopted to diagnose the cause of RLQ pain. Present study aims at analyzing the efficacy of CECT and USG in evaluation of right lower quadrant abdominal pain. Materials and Methods: Total 30 patients visited to the outpatient department with the RLQ pain who had undergone CECT and USG scan. Patients who were in need of immediate surgery and patients with abnormal renal function test were excluded from the study. Result: The mean age of the patients was 35.83 ± 19.27 years with majority of males (63.33%). Acute pain was observed in 23 (76.67%) patients and chronic pain in 7 (23.33%) patients. Appendicitis being the most common diagnosis observed in (46.67%) cases. The sensitivity of CECT was 100% for all cases. Compared to the CECT, the sensitivity of USG was 46.15% for appendicitis, 100% for renal or ureteric calculi, 66.66% for enteric infective etiology and retroperitoneal lesions and 75% for genitourinary lesions. Conclusion: Although CECT and USG were complimentary to each other, but since CECT was more sensitive than USG, therefore, it is recommended that for proper diagnosis both USG and CECT should be combined.
A PROSPECTIVE STUDY ON PRIMARY POSTPARTUM HAEMORRHAGE IN TERTIARY CARE CENTRE OVER A PERIOD OF 2 YEARS

Background: Atonic PPH is common among high-risk pregnancies. Its incidence can be lowered by universal adoption of AMTSL. Uterine atony is the major cause of primary PPH and a major threat to the life of women in labour and most important cause of maternal mortality. The present study assessed the risk factors, underlying causes, complications, morbidity and various management strategies of primary atonic PPH. Materials and Methods: This study was a prospective study conducted in a tertiary care centre over a period of two years from December 2019 to December 2021 on cases with primary atonic PPH at CKMH, Warangal. During this period a total of 8,027 deliveries were conducted. Result: Out of 8,027 deliveries, PPH was noted in 171 women. Out of these, in 140 women atonic PPH was noted accounting for 81.37% of all PPH cases. Risk of PPH is higher in both extremes of age i.e. less than 20 years and greater than 40yrs of age. In this study, 42 primigravidae and 98 parous women were noted. 82 unbooked and 58 booked cases were noted. PPH was noted in 56 vaginal deliveries and 84 caesarean sections of which 51 were emergency LSCS and 33 were done electively. The most common risk factor for atonic PPH is anemia, followed by multiparity and preeclampsia. 80 cases responded to uterotonics and uterine massage only, in 33 cases balloon tamponade was effective in controlling PPH, 18 cases needed compression sutures, in 9 cases uterine artery ligation was done and hysterectomy was done in 1 case. Most of the cases were already anemic at the time of delivery, it worsened after PPH. 41 women required transfusion which accounts for 29.2% which was the highest. Conclusion: The present study concluded that anaemia is the major risk factor contributing to PPH, followed by multiparty and preeclampsia. Early identification of risk factors and treatment of preventable ones like anaemia, implementation of prevention strategies should be mainstay of management. Avoidance of delay in identification and transfer, identification of high-risk cases and timely transfer and referral to higher centres.
ANALYSIS OF ASCITIC FLUID CYTOLOGY BY CELL BLOCK IN THE EVALUATION & GRADING OF MALIGNANCY WITH KI 67 MARKER STUDY IN A TERTIARY CARE CENTRE

Background: The cell block technique is one of the oldest methods, which is used for the evaluation of body cavity fluids. This method usually increases the yield of cellularity, gives better morphological details, and helps in improving the sensitivity of the diagnosis and grading of malignancy. Multiple sections were obtained from the prepared cell block for special stains and immunohistochemistry studies. Preparation of cell blocks of ascitic fluid in suspicious or confirmed cases of malignancy. Evaluation and grading of visceral malignancy in cell block using Ki 67 immunohistochemical marker by MIB index scoring system. Materials and Methods: Cell blocks were prepared by the plasma thromboplastin method. Sections from the blocks were stained with H&E. Immunohistochemical staining with ki67 was done for selected cases and grading was done. Result: Out of 100 samples of ascitic fluid, 14 cases were malignant. The malignancy was graded by applying the ki67 marker by the MIB index scoring system. Conclusion: Cell block method is useful for the detection and grading of malignancy by applying immunohistochemistry.
CLINICAL STUDY OF UNILATERAL HYDRONEPHROSIS AND ITS MANAGEMENT

Background: Hydronephrosis refers to aseptic dilatation of urinary tract. Unilateral hydronephrosis occurs when the obstruction is above the level of bladder. The objective is to find the commonest cause of unilateral HN in adults and management. Materials and Methods: Between March 2021 to September 2022, 50 patients of age >18 years with unilateral hydronephrosis on USG abdomen & pelvis who came as outpatients or admitted to surgery ward in Al Ameen Medical College and Hospital were included. The patients <18years, pregnant patients, patients with bilateral HN and patients with renal transplantation were not included. Result: 74% of the patients had ureteric calculi, 16% of the cases had renal calculus and 10% of the cases had PUJ obstruction. All presented with pain abdomen, burning micturition (70%), vomiting(60%), hematuria (36%), fever(28%) and mass(8%). USG abdomen and pelvis was the primary modality of diagnosis. Plain X ray KUB was able to demonstrate calculi in 32(64%) cases. In this study 41 cases were managed surgically and 9 cases with conservative treatment. Surgeries such as URSL & PCNL were done in 56% & 15% cases respectively
Supplement for “ Fine-Grained Face Swapping via Regional GAN Inversion”

Multi-scale face inversion loss. The ID loss was introduced in PSP [13] to preserve the identity of the input. Specifically, PSP uses a pre-trained face recognition network to maximize the cosine similarity between the input and the reconstructed face. Besides, the method [18] takes a step further to improve the ID loss within a multi-scale form, calculating the similarities in different feature levels. We follow these two works and apply the multi-scale ID loss constrain as:
A Persuadable Type? Personality Traits, Dissonant Information, and Political Persuasion

Is there anything like a “persuadable type” when it comes to exposure to dissonant information? Who is more likely to be swayed by information that tries to persuade them? Using data from an online sample of American respondents ( N = 1,199), we assess whether personality traits (Big Five, Dark Triad) are associated with different perceptions and effectiveness of persuasive political information. In two controlled simulations, we exposed the respondents to dissonant information related to selected political issues (environment and economy) and measured whether they showcased a stable or changed opinion afterward. Results indicate that personality matters partly for the evaluation and persuasiveness of dissonant information. More conscientious and introverted respondents were more likely to evaluate the dissonant information positively. They were at the same time also more likely to resist persuasion itself and so were more agreeable respondents. Inversely, to some extent, narcissism and psychopathy are associated with greater susceptibility to persuasion.
A COMPARATIVE STUDY OF DEXMEDETOMIDINE AND MIDAZOLAM FOR SEDATION IN PATIENTS ON MECHANICAL VENTILATION IN ICU

Background: The use of non-benzodiazepine sedatives over benzodiazepines, is now advocated in light of recent evidences, in order to improve outcome of the patients in ICU sedation. However, very few studies in the literature have compared these two most commonly used ICU Sedation agents. In present study we aim to assess and compare the efficacy of dexmedetomidine and midazolam for sedation in critically ill patients admitted in ICU. Materials and Methods: A Prospective Randomized Comparative Study including adult patients of age >18 to <65 years with a sample size of 90 of either sex admitted to the ICU requiring mechanical ventilation in ICU. Result: Out of 90 a total of 4 patients were excluded from the study due to non-survival up to 24 hrs while one cases was excluded from dexmedetomidine group due to discontinuation of drug, as it caused severe bradycardia and hypotension. So final analysis was done on 85 cases, 43 in dexmedetomidine group and 42 in midazolam group. Both the groups were comparable with regards to pulse rate, SBP, DBP, O 2 saturation at baseline and also throughout the follow up duration of 24 hours (p>0.05). Conclusion: Extubation was possible significantly earlier in cases managed by dexmedetomidine as compared to midazolam (
ASCL1 reprograms mouse Müller glia into neurogenic retinal progenitors

Non-mammalian vertebrates have a robust ability to regenerate injured retinal neurons from Müller glia (MG) that activate the gene encoding the proneural factor Achaete-scute homolog 1 (Ascl1; also known as Mash1 in mammals) and de-differentiate into progenitor cells. By contrast, mammalian MG have a limited regenerative response and fail to upregulate Ascl1 after injury. To test whether ASCL1 could restore neurogenic potential to mammalian MG, we overexpressed ASCL1 in dissociated mouse MG cultures and intact retinal explants. ASCL1-infected MG upregulated retinal progenitor-specific genes and downregulated glial genes. Furthermore, ASCL1 remodeled the chromatin at its targets from a repressive to an active configuration. MG-derived progenitors differentiated into cells that exhibited neuronal morphologies, expressed retinal subtype-specific neuronal markers and displayed neuron-like physiological responses. These results indicate that a single transcription factor, ASCL1, can induce a neurogenic state in mature MG.
LGN-dependent orientation of cell divisions in the dermomyotome controls lineage segregation into muscle and dermis

The plane of cell divisions is pivotal for differential fate acquisition. Dermomyotome development provides an excellent system with which to investigate the link between these processes. In the central sheet of the early dermomyotome, single epithelial cells divide with a planar orientation. Here, we report that in the avian embryo, in addition to self-renewing, a subset of progenitors translocates into the myotome where they generate differentiated myocytes. By contrast, in the late epithelium, individual progenitors divide perpendicularly to produce both mitotic myoblasts and dermis. To examine whether spindle orientations influence fate segregation, early planar divisions were randomized and/or shifted to a perpendicular orientation by interfering with LGN function or by overexpressing inscuteable. Clones derived from single transfected cells exhibited an enhanced proportion of mixed dermomyotome/myotome progeny at the expense of `like' daughter cells in either domain. Loss of LGN or Gαi1 function in the late epithelium randomized otherwise perpendicular mitoses and favored muscle development at the expense of dermis. Hence, LGN-dependent early planar divisions are required for the proper allocation of progenitors into either dermomyotome or myotome, whereas late perpendicular divisions are necessary for the normal balance between muscle and dermis production.
EVALUATION OF KIDNEY FUNCTION IN HYPOTHYROID SUBJECTS AND ITS CORRELATION WITH FT4 & TSH LEVEL

Background: The development of the kidneys, renal hemodynamics, glomerular filtration rate (GFR), electrolytes, and water balance are all affected by thyroid hormones. The objective of this study is to delineate the effects of thyroid hormonal status on kidney function by estimating serum creatinine, serum urea, albumin-to-creatinine ratio (ACR), and estimated glomerular function rate (eGFR) among primary hypothyroid patients. Materials and Methods: It was an Institution-based cross-sectional study done in the Department of Biochemistry in a Tertiary care Institute for a period of 1 year (Jan 2022 to Jan 2023). Renal function parameters, namely, serum creatinine, serum urea, urinary ACR, and eGFR among primary hypothyroid patients under treatment for more than 2 months were measured along with age-and sex matched controls. Apparently, healthy individuals of both male and female, without any previously known diseased condition or drug history in the age group of 25 to 55 years have been selected for the study. Among 130 individuals included in this study, 55 persons were controls and 65 individuals were primary hypothyroid patients. SPSS version 22 was used for analysis. Result: The study was done with female preponderance of 55%, while males were 45%. (F=70, M=60). The predominant age group was 25 to 40 years comprising 45% of study participants. The control group is having TSH mean value in normal range, i.e., 1.51 ± 1.16 μ IU/mL and primary hypothyroid patients on treatment having 3.66 ± 1.61 μ IU/mL. Free T4 in control was 1.27±0.17 ng/dL and in primary hypothyroid was 1.22±0.19 ng/dL. Pearson correlation analysis shows that serum creatinine, serum urea, and ACR are positively correlated with serum TSH value among patients with primary hypothyroidism (n = 65) regardless of their treatment status. Conclusion: In untreated primary hypothyroidism, renal function parameters may worsen significantly. Though the start of the treatment can cause the changed state of renal function to be reversed partially, still there is persistence of deterioration of renal function which is statistically significant.
NON-FERMENTING GRAM NEGATIVE BACTERIA: A STUDY ON THEIR PREVALENCE AND ANTIMICROBIAL SUSCEPTIBILITY PATTERN AMONG PATIENTS ADMITTED IN A TERTIARY CARE HOSPITAL, PRAYAGRAJ, UTTAR PRADESH

Background: The present study aimed to isolate and identify NFGNB from clinical samples and to assess prevalence and antimicrobial susceptibility profiles in a tertiary care hospital in Eastern India. Materials and Methods: An observational study with a cross-sectional design was conducted between January 2022 to December 2022 (1 year) in the Department of Microbiology, United Institute of Medical Sciences, Prayagraj. All the clinical samples, including urine, pus, blood, wound swab and body fluids, were received in the laboratory, inoculated on blood and Mac-Conkey agar or CLED agar, and incubated aerobically at 37°C for 18 to 24 hours. The non-lactose fermenting isolates that showed alkaline change (K/NC) reaction in triple sugar iron agar media were provisionally considered as NFGNB. They were further identified using standard protocols for identification, like gram staining for morphology, hanging drop for motility, pigment production, oxidase test, catalase test etc. Kirby-Bauer disc diffusion method performed an antimicrobial susceptibility test using commercially available discs (Hi-Media). Statistical analysis was done by using Excel and SPSS V21. Result: Out of 1021 clinical samples, cultures were positive in 695 samples. Out of 695 culture positive samples, 131 (18.8%) yielded NFGNB. The mean of our study participants was found to be 42.22 ± 12.46 years, with a male: female ratio 2.6:1. P. aeruginosa was isolated in 74/131 (56%) samples, followed by A. baumannii (50/131, 38%), Burkholderia pseudomallei (4/131, 3%), A. lwoffii (2/131, S2%), and Stenotrophomonas maltophilia were rarely isolated, accounting together for 1% of the isolates. Conclusion: Since these organisms have great potential to survive in the hospital environment, improved antibiotic stewardship and infection control measures will be needed to prevent the emergence and spread of drug-resistant NFGNB in healthcare settings.
Biomarkers for Redox-Active Genotoxins in Contaminated Sediments: A Mechanistic Approach

Feral brown bullhead catfish and environmental sediments were collected from three sites in the Niagara River system in northern New York state. The sites were Black Creek, a relatively uncontaminated reference site; the Love Canal-102nd Street dump site which was principally contaminated with chlorinated hydrocarbons (CHs) and chlorinated pesticides; and a site in the Buffalo River which was principally contaminated with polycyclic aromatic hydrocarbons (PAHs). A variety of putative biomarkers of genotoxicity and/or oxidative stress were measured in hepatic tissues of these fish. The results indicate that metabolic indices of benthic animals can successfully be used as biomarkers of exposure to environmental contaminants, especially when a suite of responses is evaluated, and that strong associations between specific responses and classes of chemicals suggest that a further refinement of this approach is feasible.
Technological Forecasting & Social Change The organisation of Corporate Foresight : A multiple case study in the telecommunication industry

Article history: Received 11 January 2013 Received in revised form 18 September 2013 Accepted 19 October 2013 Available online 19 November 2013 The present paper focuses on the organisation of Corporate Foresight (CF): how the companies design their organisation to anticipate future trends and detect weak signals. The research focuses on a multiple case-study in the telecommunication industry. The paper highlights the organisational variables that characterise a CF organisation (organisational definition, specialisation and mechanisms of internal cohesion) and relates them to CF performance measures (effectiveness and efficiency). For increasing CF performance, companies need to define a peculiar system for foresight, more “structural” or more “cultural”, to specialise for foresight, to build a control system for procedures and to model internal and external relationships. © 2013 Elsevier Inc. All rights reserved.
Utilisation des signatures de texture d'ordre eleve pour une meilleure discrimination des classes d'occupation du sol sur une image radar a synthese d'ouverture

In this work, the advantage of textural parameters of order upper than 2 for the discrimination of ground's classes' occupation on a synthetic aperture radar (SAR) image is shown. Indeed, several studies on textural classification of SAR images were made so far, but most of these studies uses the technique of the co-occurrence matrix of levels of grey, which itself is based on textural parameters of order 2. In this study, one measures textural signatures in the orders 2, 3 and 4 in four different points representing four classes of ground's occupation on a SAR ERS-1 image of the Atlantic coast of Cameroon. The textural signatures measured are established in base of 17 parameters of texture having a good capacity of discrimination. A comparison of the signatures is then made and one notices that signatures of upper order produce the best rate of discrimination of the ground's classes'occupation.