Miracle-dz/UniFAR-FTUs huggingface dataset:
Study of the clinical aspect of diabetic foot ulcers and its surgical management

Objective: Diabetes is a global epidemic and a leading cause of death by disease. It is the common underlying cause of foot ulcers, infection, and ischemia, which are among the most serious complications of diabetes. This work aimed to study the clinical profile, surgical management, and outcome of patients with diabetic foot infections. Methods: Prospective study recruiting patients >18 years of age with diabetic foot infections. All patients underwent a detailed history and clinical examination, being distributed as per their different sociodemographic, clinical, and foot ulcer site characteristics, with further management and evaluation. Results: One hundred patients were recruited, with a mean age of 51.32±11.45 years. Majority of patients (73%) had a lower socioeconomic status. All patients had type 2 diabetes, with male predominance (78%). Mean diabetes mellitus duration was 9.68±5.03 years. Ulcer (92.31%) and discharge (72.31%) were the commonest complaints. During correlation analysis, a strong statistically significant (p<0.001) correlation was observed between amputation and HBA1c level (0.747) and SINBAD score (0.871), while correlation with RBS level was weak (0.532). Commonest presenting site was forefoot, followed by hindfoot. Conclusion: The SINBAD score is simple to use in daily practice, being more effective in describing diabetic foot. Primary and secondary healthcare systems in developing countries have limited resources, using different approaches to manage diabetic foot care. The SINBAD system can be used as a primary screening tool. Provision of correct and convenient footwear and efficient treatment of minor injuries are recommended to downturn ulcer occurrence. Level of Evidence II; Prospective Study; Lesser Quality (eg, patients enrolled at different points in their disease or <80% follow-up).
Corporate Sustainability Reporting in Europe: A Scoping Review

ABSTRACT This paper provides a scoping review of European sustainability reporting studies. Previous sustainability studies do not offer a comprehensive discussion of features key to the European setting. Despite their important role in the European economy, research on small and medium-sized enterprises (SMEs) and financial institutions (i.e. insurers and banks) is limited. Furthermore, regions in southern and particularly eastern Europe, which are critical given regulators’ objectives for European Union-wide and global sustainability standards, are neglected. Finally, studies on non-financial effects of sustainability reporting are also limited, and only a few studies differentiate between stakeholder- and shareholder-oriented countries. This is needed for a holistic view on sustainability beyond financial performance. Based on material issues identified for the European context, our study provides a research agenda based on comprehensive and rigorous scientific evidence on the state of the art of sustainability research in Europe.
Pantoea agglomerans, Klebsiella pneumoniae, and Shigella flexneri isolated from the Cisadane River as multiresistant bacteria to copper and dyes

Copper pollution in Cisadane is a serious environmental issue that needs to be resolved immediately due to its negative impacts on river ecosystems. Bioremediation utilising indigenous bacteria offers excellent potential to restore copper‐contaminated river water. This study aimed to obtain indigenous copper‐resistant bacteria isolated from the Cisadane River as copper bioremediation agents. Bacteria from Cisadane River water samples were isolated by the spread plate method on Luria Bertani medium containing 3 mM CuSO4. Resistance was determined based on the minimum inhibitory concentration value, while copper concentration was measured using an atomic absorption spec‐ trophotometer. The results presented a total of 13 bacterial isolates with a minimum inhibitory concentration of up to 8 mM CuSO4. Sequence alignment analysis was performed on three selected copper‐resistant bacteria, i.e. isolate IrCis1, IrCis4 and IrCis13, which were identified as Pantoea agglomerans, Klebsiella pneumoniae and Shigella flexneri based on 16S rRNA, respectively. Each isolate accumulated copper at 1.19 mg, 1.34 mg and 0.92 mg/g DW of cells, with copper biosorption potentials of 73.74%, 70.17% and 67.73%, respectively. In conclusion, P. agglomerans strain IrCis1, K. pneu‐ moniae strain IrCis4 and S. flexneri strain IrCis5 isolated from the Cisadane River can be used as copper bioremediation agents.
PROPER ORTHOGONAL DECOMPOSITION OF RANDOM WIND PRESSURE FIELD

This paper discusses the application of the Proper Orthogonal Decomposition (POD) technique to randomly fluctuating wind pressure fields acting on a building surface. POD is a method of detecting a new coordinate system which can most efficiently represent the original fluctuating phenomena. This method can identify the deterministic or systematic structure hidden in the random fluctuations and thus help us to understand the phenomena better. It also demonstrates that the coordinate system employed is the most efficient, and can greatly reduce the amount of data that needs to be stored to re-examine the phenomena. Precautions in its application to random fields with mean values and with a singular condition are also mentioned. Furthermore, this paper introduces an example of the method's application to the evaluation of properties and the prediction of responses to wind forces acting on high-rise buildings; the validity of the method is also verified.
Measurement and Modeling of Magnetic Materials under 3D Vectorial Magnetization for Electrical Machine Design and Analysis

The magnetic properties of magnetic cores are essential for the design of electrical machines, and consequently appropriate mathematical modeling is needed. Usually, the design and analysis of electrical machines consider only the one-dimensional (1D) magnetic properties of core materials, i.e., the relationship of magnetic flux density (B) versus magnetic field strength (H), and their associated power loss under 1D magnetization, in which the B and H are constrained in the same orientation. Some studies have also been performed with the two-dimensional (2D) magnetizations in which the B and H are vectorial, rotating on a plane, and they may not be in the same direction. It has been discovered that the 2D rotational property is very different from its 1D alternating counterpart. However, the magnetic fields in an electrical machine, in particular claw pole and transverse flux machines, are naturally three-dimensional (3D), and the B and H vectors are rotational and may not lie on the same plane. It can be expected that the 3D vectorial property might be different from its 2D or 1D counterpart, and hence it should be investigated for the interests of both academic research and engineering application. This paper targets at a general summary about the magnetic material characterization with 3D vectorial magnetization, and their application prospect in electrical machine design and analysis.
How Russia’s trade with China influences carbon dioxide emissions in Russian regions

The Sino-Russian partnership has become one of the hottest issues in contemporary international politics. Significantly, the highest potential is in the movement of both countries to Carbon Neutrality. China pursues the goal to reach its carbon peak by 2030, aiming to achieve net-zero carbon dioxide emissions. The Russian government is also involved in new programs concerning emissions reduction. The two countries plan to collaborate on a new level of responsibility and transregional interconnection. The paper aims to analyze the influence of Russia’s trade with China on carbon dioxide emissions in Russian regions. The authors present a review of carbon dioxide emissions between the two countries, explore the processes of trade in several categories of products and outline forward forecast tendencies. The paper uses complicated forecasting modeling in Python to assess the prospects of trade collaboration between Russia and China untill 2030. It makes forecasts of the volumes of carbon dioxide emissions and environmental trends till 2030. The research results show that the highest levels of emissions are observed in the industries “Mineral products”, “Chemical products” and “Animal husbandry and fishing products and services”, while “Wood works and furniture”, and “Agriculture products and services” produce considerably fewer emissions.
Socket preservation using autogenous bone graft and dentin autograft after surgical removal of impacted mandibular third molar – A split-mouth study design

Introduction: In our study, we have compared the efficacy of dentin bone graft for purpose of ridge preservation and have compared it with autogenous bone graft (ABG). A total of 15 patients were included in this study requiring extraction of bilaterally impacted third molar. On the one side, the socket was filled with processed dentin graft prepared after extraction of the third molar, and on the other side, the socket was filled with ABG harvested from external oblique ridge. The two were compared on the basis of various soft tissue and hard tissue parameters. Aims: This study aimed to evaluate and compare the efficacy of the dentin autograft with ABG for preservation of socket defect after removal of mandibular third molars clinically and radiographically. Materials and Methods: A total of 15 patients were included undergoing extraction for bilaterally impacted third molar. The socket on one side after extraction was filled with processed dentin from the same extracted tooth, and the other side of the socket was filled with ABG harvested from the external oblique ridge. Results: It was seen that dentin graft had the regenerative properties and showed potential for ridge preservation. Conclusions: Ridge preservation is essential for placement of implant and other prostheses. Preservation of ridge immediately after extraction bypasses the need for extensive ridge augmentation procedure. Hence, dentin graft can be used for this purpose as it has potential for bone regeneration.
Linear resonant duct thermoacoustic refrigerator having two regenerator stacks

The measurements of acoustically generated temperature difference between the two ends of a TAC (thermoacoustic couple) in a resonant tube are made using the similar method suggested by Atchley et al. [J. Acoust. Soc. Am. 88, 251–263 (1990)] with a ceramic TAC cylinder. The linear duct was made of PVC pipe with an inner diameter of 30 mm and 680 mm long. Measurements are made for a frequency range of 150–350 Hz in atmospheric air along the TAC length from 2.5 to 10 cm with a 1‐cm step. The unknown information of ceramic can be obtained from nonlinear fitting of experimental data with the equation reported by Atchley et al. From the result of this experiment and prediction by theory it is found that the direction of acoustic heat transport is altered at the point of a quarter of a wavelength. From the hint of the above experiment, a newly designed thermoacoustic refrigerator having two regererator stacks is tested.
On the minimal representation of non-linear eddy-viscosity models

This study attempts to provide a minimal explicit non-linear relationship between the Reynolds stresses and the mean strain rate and vorticity. Such relationship is also referred to as the nonlinear eddy-viscosity model (EVM) of the Reynolds stresses. Based on the observation of the independent terms in the Reynolds stress anisotropy tensor, it is proposed here that the explicit Reynolds stress closure can be formulated in a compact vorticity tensor to form a minimal representation. With the application of the generalized Cayley–Hamilton theory, it is shown that the explicit algebraic stress model with 10 integrity bases can be transformed into a five-term model expression. Thus, the present work provides a framework for the development of the explicit Reynolds stress closure in the compact form. Indeed, a cubic EVM is developed here that is capable of revealing the quadratic behaviour of the tangential velocity with respect to the radial distance in the fully developed turbulent rotating pipe flow. This model, hence, removed some major defects in the lower-order EVMs, while the model complexity is kept at minimum.
High-frequency-induced phase-dependent dc current by Bloch oscillator non-ohmicity

A calculation is presented for the phase-dependent dc current induced in a semiconductor superlattice by the simultaneous application of an ac field and its phase-shifted second harmonic. The dc current is a result of the Esaki–Tsu non-ohmicity of the superlattice for the case where it Bloch oscillates. The effect provides a tool for a determination of the relaxation time of the electrons.
Spatial Distribution of Groundwater Level over Lowlands of Morang District of Eastern-Nepal

A better understanding of spatial distribution of groundwater level is necessary for the development of groundwater development strategies and sustainable use of available resources. The present study evaluates the spatial distribution of groundwater level over the Morang Administrative District of Eastern Nepal and the groundwater accessibility over the area. The study was realized by performing an extensive field survey of groundwater level during the post-monsoon season over 126 sites. The study area of 1224.80 km2 was gridded at 3 km x 3 km horizontal grid resolution and at least one survey was ensured for each grid point. Downscaled spatial distribution of groundwater level was achieved by interpolating the observed data using the Inverse Distance Weighting (IDW) with different weighting parameters available with the geostatistical module of ArcGIS. The performances of the interpolation methods were evaluated based on the cross-validation of results characterized by the statistical parameters RMSE, R2 and MAE and optimal power (α) for weighting function. The IDW (with α=4) appears to perform well for the study area with Coefficient of Determination (R2) and Root Mean Square Error (RMSE) and Mean Absolute Error (MAE) values of 0.336, 4.750 and 2.967, respectively. The spatial distribution of groundwater level over the low-lands of Morang District mapped with the IDW interpolation method, revealed that the ground water level is maximum in south-western part of the district. The depth to groundwater lies between the ranges of 4.5 to 10 meters covering almost 67.47% of the total study area.
The optimal uniform approximation of systems of stochastic differential equations

We analyze numerical methods for the pathwise approximation of a system of stochastic differential equations. As a measure of performance we consider the qth mean of the maximum distance between the solution and its approximation on the whole unit interval. We introduce an adaptive discretization that takes into account the local smoothness of every trajectory of the solution. The resulting adaptive Euler approximation performs asymptotically optimal in the class of all numerical methods that are based on a finite number of observations of the driving Brownian motion.
Hypoxic mesenchymal stem cell‐conditioned medium accelerates wound healing by regulating IL‐10 and TGF‐β levels in a full‐thickness‐wound rat model

Full‐thickness wound healing is a complex process requiring a well‐orchestrated mechanism of various factors, including cytokines, particularly interleukin (IL)‐10 and transforming growth factor (TGF)‐β. IL‐10 and TGF‐β act as robust anti‐inflammatory cytokines in accelerating the wound healing process by regulating myofibroblasts. Hypoxic mesenchymal stem cell‐conditioned medium (hypMSC‐CM) containing cytokines potentially contribute to accelerate wound repair without scarring through the paracrine mechanism. This study aims to observe the role of hypMSC‐CM in controlling TGF‐β and IL‐10 levels to accelerate full‐thickness wound repair and regeneration. A total of 24 male Wistar rats were used in this study. Six healthy rats as a sham group and 18 rats were created as full‐thickness‐wound animal models using a 6 mm punch biopsy. The animals were randomly assigned into three groups (n = 6) consisting of two treatment groups treated with hypMSC‐CM at a low dose (200 µL hypMSC‐CM with 2 g water‐based gel added) and a high dose (400 µL hypMSC‐CM with 2 g water‐based gel added) and a control group (2 g water‐based gel only). The IL‐10 and TGF‐β levels were examined by ELISA. The results showed a significant increase in IL‐10 levels on day 3 after hypMSC‐CM treatment, followed by a decrease in platelet‐derived growth factor (PDGF) levels on days 6 and 9. In line with this finding, the TGF‐β levels also increased significantly on day 3 and then linearly decreased on days 6 and 9. HypMSC‐CM administra‐ tion may thus promote wound healing acceleration by controlling IL‐10 and TGF‐β levels in a full‐thickness‐wound rat model.
Management of middle lobe veins during single-portal video-assisted thoracoscopic surgery lobectomy via the fifth intercostal approach (case series): why the subcarinal triangular right base angle is helpful

Background The fifth intercostal space is the preferred approach during uniportal video-assisted thoracoscopic surgery (VATS) lobectomy. However, managing the right middle lobe pulmonary vein (RML PV) through this approach is technically challenging for inexperienced surgeons. To facilitate the surgical procedure, we describe our surgical strategy for managing the middle lobe vein via the fifth intercostal space and define the approach [subcarinal triangular right base angle (SCT-RBA)] utilized to manage the middle lobe vein. Case Description Based on the characteristics of uniportal surgery, we designed a new method of managing middle lobar veins via the fifth intercostal approach, which also facilitates the dissection of the subcarinal lymph nodes. We described the short-term surgical outcomes of 7 patients who underwent single-port middle lobe resection from January 2021 to January 2022 in the Department of Thoracic Surgery, Ruijin Hospital North Campus, Shanghai Jiaotong University School of Medicine. No conversion and mortality were observed in 7 patients who underwent single-port VATS middle lobe resection. One patient had bronchial asthma and air leakage, which led to delayed drainage and hospitalization. There were no complications or delayed discharge reported among the other patients. Conclusions Our initial results indicate that this new technique is a feasible strategy to manage the middle lobe veins and facilitate the dissection of subcarinal lymph nodes.
“Muskets and Rainbows”: Why a Mormon Leader’s BYU Speech Failed, Metaphorically

The use of metaphors in religious rhetoric can be persuasive, inclusive, and edifying. They can also be belligerent, harmful, and divisive. This paper investigates the backlash against the use of a “muskets” metaphor in a recent speech by a prominent Mormon leader which targeted LGBTQ+ members, in the wider context of a traditionally fraught relationship between the Church and its LGBTQ+ membership. This paper argues that the speech represents an act of authoritarianism, reliant upon the institutionally-situated power of a Church leader. Critics have interpreted the speech’s use of violent metaphor as an unwarranted attack on some of the most vulnerable members of the Mormon community, paradoxically at a time when the Church was seen as moving towards a more inclusive position in doctrine and policy.
Pharmacokinetics and pharmacodynamics of approved monoclonal antibody therapy for colorectal cancer

ABSTRACT Introduction The introduction of monoclonal antibodies to the chemotherapy backbone treatment has challenged the paradigm of metastatic colorectal cancer (mCRC) treatment. Their mechanism of action and pharmacokinetics are complex but important to understand in order to improve patient selection and treatment outcomes for mCRC population. Areas covered This review examines the scientific data, pharmacodynamics, and pharmacokinetics of approved monoclonal antibodies used to treat mCRC patients, including agents targeting signaling via VEGFR (bevacizumab and ramucirumab), EGFR (cetuximab and panitumumab), HER2/3 target therapy, and immunotherapy agents such as pembrolizumab or nivolumab. Efficacy and mechanism of action of bispecific antibodies are also covered. Expert opinion mCRC is a heterogeneous disease and the optimal selection and sequence of treatments is challenging. Monoclonal antibodies have complex pharmacokinetics and pharmacodynamics, with important interactions between them. The arrival of bioequivalent molecules to the market increases the need for the characterization of pharmacokinetics and pharmacodynamics of classic monoclonal antibodies to reach bioequivalent novel molecules.
Perturbation Pressure Fields Measured by Aircraft around the Cloud-Base Updraft of Deep Convective Clouds

Abstract Perturbation pressure fields are measured by aircraft around the cloud base updrafts of seven clouds ranging in size from weak cumulus congestus to intense cumulonimbus during CCOPE (1981). The fields are characterized by a high-low pressure couplet of similar size to the updraft, but a quarter-wavelength out of Phase, with the minimum pressure downshear of the updraft maximum. An estimate of the terms in the Poisson equation for pressure show that the pressure perturbation results chiefly from the interaction of the updraft with the vertical shear of the environmental horizontal wind. The behavior of the pressure oscillation is well predicted by inserting sinusoidal functions in the corresponding terms in the Poisson equation. The amplitude of the pressure oscillation is proportional to the wavelengths of the pressure and vertical-velocity fields, the amplitude of the vertical-velocity oscillation, and the vertical shear of the horizontal environmental wind through cloud base, measured in the di.