Miracle-dz/UniFAR-FTUs huggingface dataset:
Biomarkers of Cardiovascular Diseases in Saliva and Gingival Crevicular Fluid: A Review

Due to the fact that cardiovascular diseases (CVDs) have become the most serious problem in public health, there is a need for new and efficient methods for screening and early detection. In the recent literature, saliva and gingival crevicular fluid (GCF) have been gaining recognition as sources of many potential biomarkers of various systemic diseases, mainly because of correlation between the level of some compounds in the blood and saliva and association between the composition of saliva and health status. In this review, we summarize published findings of patients with atherosclerosis, arterial hypertension, coronary artery disease (CAD), acute coronary syndrome (ACS), and stroke in the context of clinical utility of saliva and GCF in diagnosing and assessing CVD severity. We hypothesize that substances in saliva including inflammatory markers, enzymes, or hormones might become novel contributors to the diagnosis and screening of CVDs. In particular, C-reactive protein (CRP), tumor necrosis alpha (TNFα), and cortisol seem to be the most promising. However, further investigation is warranted to determine the most effective markers and methods for their analysis.
The indication for aseptic revision TKA does not influence 1-year outcomes: an analysis of 178 full TKA revisions from a prospective institutional registry

Background and purpose Outcomes following revision total knee arthroplasty (TKA) may depend on the indication for revision surgery. We compared pain, patientreported outcome measures (PROMs), and patient satisfaction among different indications for an aseptic TKA revision. Patients and methods This was a retrospective study of prospective data from an institutional registry of 178 primary TKAs revised between 2012 and 2020. Patients were grouped by the main reason for their revision: loosening, malposition, instability, or stiffness. Pain during mobilization and at rest (NRS 0–10), physical function (KOOS-PS and KSS), and quality of life (EQ-5D) were surveyed preoperatively and at 2 months and 1 year postoperatively. Patient satisfaction was evaluated through questions related to knee function and their willingness to undergo the same surgery again at 1-year follow-up. Results Pain and PROMs improved in all groups and did not differ statistically significantly between the 4 groups at 1-year follow-up, but equivalence for pain was not confirmed between groups. Overall, pain during mobilization improved by 2.4 (95% CI 1.9–3.0) at 1-year followup, which was both clinically and statistically significant. Improvements were seen within 2 months of surgery, with no further improvements seen 1 year postoperatively. Approximately 2/3 of patients reported that their knee function had improved and would undergo the same surgery again, at 1-year follow-up. Conclusion Statistically significant and clinically relevant improvements in pain and PROMs were seen in all 4 revision groups 1 year after revision TKA. These results may assist clinicians and patients during preoperative counselling.
Effect of an electromagnetic field on the spectra and elliptic flow of particles

In 2+1 dimensions, the evolution of flow under the influence of an external electromagnetic field is simulated. The external electromagnetic field is exponentially decaying with time. Under the same initial conditions, flow evolution with and without the external electromagnetic field is compared. It was found that the production of particles was enhanced when the external electromagnetic field was present. As the strength of the electromagnetic field increased, more particles were produced. Enhancement is greater at the high transverse momentum than at the low transverse momentum. In addition, the electromagnetic field also modifies the elliptic flow and the modification is related to the mass and charge of the particles.
Initial soil organic carbon stocks govern changes in soil carbon: Reality or artifact?

Changes in soil organic carbon (SOC) storage have the potential to affect global climate; hence identifying environments with a high capacity to gain or lose SOC is of broad interest. Many cross‐site studies have found that SOC‐poor soils tend to gain or retain carbon more readily than SOC‐rich soils. While this pattern may partly reflect reality, here we argue that it can also be created by a pair of statistical artifacts. First, soils that appear SOC‐poor purely due to random variation will tend to yield more moderate SOC estimates upon resampling and hence will appear to accrue or retain more SOC than SOC‐rich soils. This phenomenon is an example of regression to the mean. Second, normalized metrics of SOC change—such as relative rates and response ratios—will by definition show larger changes in SOC at lower initial SOC levels, even when the absolute change in SOC does not depend on initial SOC. These two artifacts create an exaggerated impression that initial SOC stocks are a major control on SOC dynamics. To address this problem, we recommend applying statistical corrections to eliminate the effect of regression to the mean, and avoiding normalized metrics when testing relationships between SOC change and initial SOC. Careful consideration of these issues in future cross‐site studies will support clearer scientific inference that can better inform environmental management.
Modelling the nebular emission from primeval to present-day star-forming galaxies

We present a new model of the nebular emission from star-forming galaxies in a wide range of chemical compositions, appropriate to interpret observations of galaxies at all cosmic epochs. The model relies on the combination of state-of-the-art stellar population synthesis and photoionization codes to describe the ensemble of H ii regions and the diffuse gas ionized by young stars in a galaxy. A main feature of this model is the self-consistent yet versatile treatment of element abundances and depletion on to dust grains, which allows one to relate the observed nebular emission from a galaxy to both gas-phase and dust-phase metal enrichment. We show that this model can account for the rest-frame ultraviolet and optical emission-line properties of galaxies at different redshifts and find that ultraviolet emission lines are more sensitive than optical ones to parameters such as C/O abundance ratio, hydrogen gas density, dust-to-metal mass ratio and upper cut-off of the stellar initial mass function. We also find that, for gas-phase metallicities around solar to slightly subsolar, widely used formulae to constrain oxygen ionic fractions and the C/O ratio from ultraviolet and optical emission-line luminosities are reasonable faithful. However, the recipes break down at non-solar metallicities, making them inappropriate to study chemically young galaxies. In such cases, a fully self-consistent model of the kind presented in this paper is required to interpret the observed nebular emission.
Phosphoregulation of the transcription factor Mxr1 plays a crucial role in the concentration‐regulated methanol induction in Komagataella phaffii

Methylotrophic yeasts can utilize methanol as the sole carbon and energy source, and the expression of their methanol‐induced genes is regulated based on the environmental methanol concentration. Our understanding of the function of transcription factors and Wsc family of proteins in methanol‐induced gene expression and methanol sensing is expanding, but the methanol signal transduction mechanism remains undetermined. Our study has revealed that the transcription factor KpMxr1 is involved in the concentration‐regulated methanol induction (CRMI) in Komagataella phaffii (Pichia pastoris) and that the phosphorylation state of KpMxr1 changes based on methanol concentration. We identified the functional regions of KpMxr1 and determined its multiple phosphorylation sites. Non‐phosphorylatable substitution mutations of these newly identified phosphorylated threonine and serine residues resulted in significant defects in CRMI. We revealed that KpMxr1 receives the methanol signal from Wsc family proteins via KpPkc1 independent of the mitogen‐activated protein kinase (MAPK) cascade and speculate that the activity of KpPkc1 influences KpMxr1 phosphorylation state. We propose that the CRMI pathway from Wsc to KpMxr1 diverges from KpPkc1 and that phosphoregulation of KpMxr1 plays a crucial role in CRMI.
Orbifold Riemann-Roch and Hilbert series

A general Riemann-Roch formula for smooth Deligne-Mumford stacks was obtained by Toen [Toe99]. Using this formula, we obtain an explicit Riemann-Roch formula for quasismooth substacks of weighted projective space, following the ideas in [Nir]. The Riemann-Roch formula enables us to study polarized orbifolds in terms of the associated Hilbert series. Given a polarized projectively Gorenstein quasismooth pair (X, Od∈Z O(d)), we want to parse the Hilbert series P(t) = ∑d>=0 h0(X,OX (d))td according to the orbifold loci. For X with only isolated orbifold points, we give a parsing such that each orbifold point corresponds to a closed term, which only depends on the orbifold type of the point and has Goresntein symmetry property and integral coefficients. Similarly, for the case when X has dimension <= 1 orbifold loci, we can also parse the Hilbert series into closed terms corresponding to orbifold curves and dissident points as well as isolated orbifold points. Our parsing of Hilbert series reflects the global symmetry property of the Gorenstein ring Od>=0 H0(X,OX (d))td in terms of its local data.
Postural control paradigm (BioVRSea): towards a neurophysiological signature

Objective. To define a new neurophysiological signature from electroencephalography (EEG) during a complex postural control task using the BioVRSea paradigm, consisting of virtual reality (VR) and a moving platform, mimicking the behavior of a boat on the sea. Approach. EEG (64 electrodes) data from 190 healthy subjects were acquired. The experiment is composed of 6 segments (Baseline, PRE, 25%, 50%, 75%, POST). The baseline lasts 60 s while standing on the motionless platform with a mountain view in the VR goggles. PRE and POST last 40 s while standing on the motionless platform with a sea simulation. The 3 other tasks last 40 s each, with the platform moving to adapt to the waves, and the subject holding a bar to maintain its balance. The power spectral density (PSD) difference for each task minus baseline has been computed for every electrode, for five frequency bands (delta, theta, alpha, beta, and low-gamma). Statistical significance has been computed. Main results. All the bands were significant for the whole cohort, for each task regarding baseline. Delta band shows a prefrontal PSD increase, theta a fronto-parietal decrease, alpha a global scalp power decrease, beta an increase in the occipital and temporal scalps and a decrease in other areas, and low-gamma a significant but slight increase in the parietal, occipital and temporal scalp areas. Significance. This study develops a neurophysiological reference during a complex postural control task. In particular, we found a strong localized activity associated with certain frequency bands during certain phases of the experiment. This is the first step towards a neurophysiological signature that can be used to identify pathological conditions lacking quantitative diagnostics assessment.
Ferret acute lung injury model induced by repeated nebulized lipopolysaccharide administration

Inflammatory lung diseases affect millions of people worldwide. These diseases are caused by a number of factors such as pneumonia, sepsis, trauma, and inhalation of toxins. Pulmonary function testing (PFT) is a valuable functional methodology for better understanding mechanisms of lung disease, measuring disease progression, clinical diagnosis, and evaluating therapeutic interventions. Animal models of inflammatory lung diseases are needed that accurately recapitulate disease manifestations observed in human patients and provide an accurate prediction of clinical outcomes using clinically relevant pulmonary disease parameters. In this study, we evaluated a ferret lung inflammation model that closely represents multiple clinical manifestations of acute lung inflammation and injury observed in human patients. Lipopolysaccharide (LPS) from Pseudomonas aeruginosa was nebulized into ferrets for 7 repeated daily doses. Repeated exposure to nebulized LPS resulted in a restrictive pulmonary injury characterized using Buxco forced maneuver PFT system custom developed for ferrets. This is the first study to report repeated forced maneuver PFT in ferrets, establishing lung function measurements pre‐ and post‐injury in live animals. Bronchoalveolar lavage and histological analysis confirmed that LPS exposure elicited pulmonary neutrophilic inflammation and structural damage to the alveoli. We believe this ferret model of lung inflammation, with clinically relevant disease manifestations and parameters for functional evaluation, is a useful pre‐clinical model for understanding human inflammatory lung disease and for the evaluation of potential therapies.
Longitudinal Tau PET Using 18F-Flortaucipir: The Effect of Relative Cerebral Blood Flow on Quantitative and Semiquantitative Parameters

Visual Abstract Semiquantitative PET measures such as SUV ratio (SUVr) have several advantages over quantitative measures, such as practical applicability and relative computational simplicity. However, SUVr may potentially be affected by changes in blood flow, whereas quantitative measures such as nondisplaceable binding potential (BPND) are not. For 18F-flortaucipir PET, the sensitivity of SUVr for changes in blood flow is currently unknown. Therefore, we compared semiquantitative (SUVr) and quantitative (BPND) parameters of longitudinal 18F-flortaucipir PET scans and assessed their vulnerability to changes in blood flow. Methods: Subjects with subjective cognitive decline (n = 38) and Alzheimer disease patients (n = 24) underwent baseline and 2-y follow-up dynamic 18F-flortaucipir PET scans. BPND and relative tracer delivery were estimated using receptor parametric mapping, and SUVr at 80–100 min was calculated. Regional SUVrs were compared with corresponding distribution volume ratio (BPND + 1) using paired t tests. Additionally, simulations were performed to model effects of larger flow changes in different binding categories. Results: Results in subjective cognitive decline and Alzheimer disease showed only minor differences between SUVr and BPND changes over time. Relative tracer delivery changes were small in all groups. Simulations illustrated a variable bias for SUVr depending on the amount of binding. Conclusion: SUVr provided an accurate estimate of changes in specific binding for 18F-flortaucipir over a 2-y follow-up during which changes in flow were small. Notwithstanding, simulations showed that large(r) flow changes may affect 18F-flortaucipir SUVr. Given that it is currently unknown to what order of magnitude pharmacotherapeutic interventions may induce changes in cerebral blood flow, caution may be warranted when changes in flow are potentially large(r), as in clinical trials.
Near-infrared properties of 12 globular clusters towards the inner bulge of the Galaxy

We present near-infrared colour–magnitude diagrams and physical parameters for a sample of 12 galactic globular clusters located towards the inner bulge region. For each cluster we provide measurements of the reddening, distance and photometric metallicity and of the luminosity of the horizontal branch red clump and the red giant branch bump and tip. The sample discussed here, together with that presented in Valenti, Ferraro & Origlia (2007), represents the largest homogeneous catalogue of bulge globular clusters (comprising ∼80 per cent of the entire bulge cluster population) ever studied. The compilation is available in electronic form on the World Wide Web (http://www.bo.astro.it/~GC/ir_archive).
The potential immunotoxicity of emamectin benzoate on the human THP‐1 macrophages

Emamectin benzoate (EMB) as one of the typical biological pesticides has a wide range of applications in agriculture. However, the immune toxic effects of EMB in human received limited attention. In our study, THP‐1 macrophage as an in vitro model was used to evaluate immune functions exposed to EMB. We observed that EMB inhibited phagocytic activity and respiratory burst capacity of macrophages without inducing cellular toxicity, implying the potential immunosuppression. Besides, EMB disturbed the cytokines balance embodied in the increase of TNF‐α, IL‐1β, IL‐6, CCL27, CXCL8 mRNA expression and the decrease of IL‐4, IL‐13, IL‐10 mRNA expression. EMB could exhibit pro‐inflammatory responses in macrophages and promote the conversion of macrophages to M1 phenotype. Moreover, NF‐κB pathway involved in regulating immune function from KEGG pathway analysis. EMB exposure could activate the NF‐κB pathway in THP‐1 macrophages by exploring the critical proteins. This research provided insights on immunotoxicity evaluation and clarified EMB‐induced immunotoxicity was related to NF‐κB pathway activation.
Concurrent Intimate Partner Violence: Survivors’ Health and Help-Seeking

This study examined intimate partner violence patterns using the National Intimate Partner and Sexual Violence Survey, a nationally representative sample collected in 2010. The latent class analysis detected six distinctive patterns: Sexual Violence, Psychological Aggression, Multiple Violence, Coercive Control, Physical and Psychological Violence, and Stalking. Multiple Violence was the most common among males, while Coercive Control was the most common among females. Multiple Violence and Physical and Psychological Violence perpetrators inflicted more negative health consequences than the other types. Intervention and prevention approaches that consider perpetrator types as a part of survivor need assessments will improve services.
Experimental realization of Feynman’s ratchet

Feynman’s ratchet is a microscopic machine in contact with two heat reservoirs, at temperatures TA and TB, that was proposed by Richard Feynman to illustrate the second law of thermodynamics. In equilibrium (TA = TB), thermal fluctuations prevent the ratchet from generating directed motion. When the ratchet is maintained away from equilibrium by a temperature difference ( T A ≠ T B ), it can operate as a heat engine, rectifying thermal fluctuations to perform work. While it has attracted much interest, the operation of Feynman’s ratchet as a heat engine has not been realized experimentally, due to technical challenges. In this work, we realize Feynman’s ratchet with a colloidal particle in a one-dimensional optical trap in contact with two heat reservoirs: one is the surrounding water, while the effect of the other reservoir is generated by a novel feedback mechanism, using the Metropolis algorithm to impose detailed balance. We verify that the system does not produce work when TA = TB, and that it becomes a microscopic heat engine when T A ≠ T B . We analyze work, heat and entropy production as functions of the temperature difference and external load. Our experimental realization of Feynman’s ratchet and the Metropolis algorithm can also be used to study the thermodynamics of feedback control and information processing, the working mechanism of molecular motors, and controllable particle transportation.
Toroidal vortices as a solution to the dust migration problem

The figures were created using SPLASH (Price 2007), an SPH visualization tool publicly available at http://users.monash. edu.au/∼dprice/splash. This Letter was supported by the STFC consolidated grant ST/J001627/1, and by the European Research Council under the European Community's Seventh Framework Programme (FP7/2007-2013 grant agreement no. 339248). This Letter used the DiRAC Complexity system, operated by the University of Leicester IT Services, which forms part of the STFC DiRAC HPC Facility (www.dirac.ac.uk). This equipment is funded by BIS National E-Infrastructure capital grant ST/K000373/1 and STFC DiRAC Operations grant ST/K0003259/1. DiRAC is part of the National E-Infrastructure. This Letter also used the University of Exeter Supercomputer, a DiRAC Facility jointly funded by STFC, the Large Facilities Capital Fund of BIS and the University of Exeter.
Which variables moderate the relationship between depressive symptoms and global neurocognition across adulthood?

ABSTRACT The current study examined moderators of the relationship between depressive symptoms and global neurocognition in a large non-clinical community-dwelling sample spanning adulthood. Participants comprised 5,430 individuals between the ages of 18–99 years drawn from the Virginia Cognitive Aging Project. Depressive symptoms were measured via the Center for Epidemiologic Studies-Depression scale and neurocognition was operationalized as a composite variable comprising episodic memory, spatial visualization, processing speed, and reasoning tasks. Moderator variables included physical activity, cognitive activity, education, emotional stability, and openness. Hierarchical regressions were used to examine the influence of depressive symptoms and the moderators on neurocognition. Depressive symptoms significantly predicted neurocognition. Cognitive activity, years of education, and emotional stability moderated the depression-neurocognition relationship by buffering the impact of depressive symptoms on neurocognition. Cognitive activity engagement and level of education may function as a protective influence on those with higher levels of depressive symptoms, while emotional stability may be protective for individuals with lower levels of depressive symptoms. No differences in moderation were found across three age groups representing younger, middle, and older adults. Post-hoc analyses showed years of education and openness as moderators in a subsample excluding individuals with potentially clinically meaningful levels of depressive symptoms.
VLBA 24 and 43 GHz observations of massive binary black hole candidate PKS 1155 + 251

PKS 1155 + 251 is a radio-loud quasar source at z = 0.203. Observations using very long baseline interferometry (VLBI) at ∼2, 5, 8 and 15 GHz show that the structure of the radio source is quite complicated on parsec scales and that the outer hotspots are apparently undergoing a significant contraction. Because these results cannot be fully explained based on the compact symmetric object (CSO) scenario with a radio core located between the northern and southern complexes, we made observations with the Very Long Baseline Array (VLBA) at 24 and 43 GHz to search for compact substructures and alternative interpretations. The results show that the radio core revealed in the previous VLBI observations remains compact with a flat spectrum in our sub-milli-arcsecond–resolution images; the northern lobe emission becomes faint at 24 GHz and is mostly resolving out at 43 GHz; the southern complex is more bright but has been resolved into the brightest southern-end (S1) and jet or tail alike components westwards. Explaining the southern components aligned westward with a standard CSO scenario alone remains a challenge. As for the flatter spectral index of the southern-end component S1 between 24 and 43 GHz in our observations and the significant 15 GHz VLBA flux variability of S1, an alternative scenario is that the southern complex may be powered by a secondary black hole residing at S1. But more sensitive and high-resolution VLBI monitoring is required to discriminate the CSO and the binary black hole scenarios.
Frequent Flaring in the TRAPPIST-1 System—Unsuited for Life?

We analyze the K2 light curve of the TRAPPIST-1 system. The Fourier analysis of the data suggests Prot = 3.295 ± 0.003 days. The light curve shows several flares, of which we analyzed 42 events with integrated flare energies of 1.26 × 1030–1.24 × 1033 erg. Approximately 12% of the flares were complex, multi-peaked eruptions. The flaring and the possible rotational modulation shows no obvious correlation. The flaring activity of TRAPPIST-1 probably continuously alters the atmospheres of the orbiting exoplanets, which makes these less favorable for hosting life.