Miracle-dz/UniFAR-FTUs huggingface dataset:
Prevalence of concussion and adherence to return-to-play guidelines amongst male secondary school rugby and hockey players

Background Concussion injuries are common in contact sports. Young players can suffer life-threatening complications if concussion is not recognised and managed. Objectives To determine the prevalence of concussion amongst secondary school rugby and hockey players and describe players’ knowledge and adherence to return-to-play guidelines. Method A mixed-method approach included Phase A, which utilised a questionnaire completed by 221 players (n = 139 rugby; n = 82 hockey) between 13 and 18 years of age, and Phase B, which utilised three focus group discussions of 15 participants who had suffered a concussion. Results The prevalence of concussion (n = 221) was 31.2% (n = 69). Of those, 71% (n = 49) were rugby players. Those who had suffered a concussion were more confident in identifying symptoms of concussion in themselves and others compared with those who did not suffer a concussion (p = 0.001), were more aware of return-to-play guidelines and more confident in their knowledge of concussion (p = 0.001). There were no differences between groups when identifying concussion symptoms. Of those who had a concussion, 30.4% (n = 21) adhered to return-to-play guidelines and followed graded return-to-play after their concussion. Explanations for non-adherence to return-to-play protocols included peer pressure, intrinsic motivation and ignorance. Conclusion Nearly a third had suffered a concussion injury; having suffered a concussion, and awareness of return-to-play guidelines, did not guarantee adherence to return-to-play protocols. Peer pressure and intrinsic factors explained this lack of adherence. Clinical implications Physiotherapists are often involved with the diagnosis and management of concussion injuries among rugby and hockey players. Understanding the prevalence and the reasons why young players do not adhere to the ‘return to play’ guidelines may inform preventative strategies.
Particle Size Analysis: A comparative study of various methods

The particle size distribution of component materials can be important parameter governing the proper function of many industrial products. At present, accurate determination of particle size by currently available methods is difficult for both theoretical and practical reasons. In this paper, some elementary notions regarding particle sizing are reviewed as is the relative performance of commercially available particle sizing instrumentation which could be used for particle size analysis of dry powders. Our results indicate that various particle size instruments yield significantly (even vastly) different particle size distributions for the same material. Without great care on the part of the investigator, the results obtained from any given instrument may not accurately describe the powder in question and thus may cause incorrect technical recommendations. The use of Fraunhofer diffraction instruments on samples containing irregularly shaped small ( < 10 μm) particles of low refractive index requires considerable caution.
Clinical and Demographic Characteristics Including Comorbidities and Their Outcomes Among Patients Hospitalized With COVID-19 in Four Tertiary Care Hospitals Across Lahore

Background The first case of infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was diagnosed in Wuhan, China, in 2019. By the first half of 2020, coronavirus disease 2019 (COVID-19) turned into a global pandemic. Objectives The aim of this study is to describe the clinical and demographic characteristics including comorbidities and their outcomes among patients hospitalized with COVID-19 in four tertiary care hospitals across Lahore. This retrospective study was conducted at Fatima Memorial Hospital, Sir Ganga Ram Hospital, Lahore General Hospital, and Jinnah Hospital, all in Lahore, Pakistan, from May 1, 2020, to June 30, 2020. The sample size was 445, which was derived using the convenient sampling method. Clinical outcomes during hospitalization included the requirement of invasive positive pressure ventilation, need for renal replacement therapy (RRT), and death. Data regarding demographics, baseline comorbidities, important vital signs on reporting, and initial workup with results were also collected. Results A total of 445 patients’ data were studied, of whom 291 (65.4%) were male patients and 154 (34.6%) female patients. The median age was 54 years (interquartile range [IQR]: 24). The most common comorbidities were hypertension (HTN) (195; 43.8%) followed by diabetes mellitus (DM) (168; 37.8%) and cardiovascular disease (CVD) (61; 13.7%). The median length of hospital stay was eight days (IQR: 3). Of the total patients, 137 (30.7%) were treated in intensive care unit settings, 40 (9%) received invasive mechanical ventilation, 40 (9%) patients had acute kidney injury, 38 (8.5%) received RRT, and 37 (8.3%) died. It was seen that more patients who were either diabetic or hypertensive received invasive mechanical ventilation as compared to those who did not have these comorbidities. The most common radiological finding on chest X-ray was the classical ground-glass appearance of COVID-19, which was found in 318 (71.4%) patients. Conclusions Patients with one or more underlying comorbidities had poor clinical outcomes compared to those with no comorbidities, with the most vulnerable group being patients with chronic kidney disease, DM, HTN, and CVD in descending order.
Expression of PD1/PDL1 in gastric cancer at different microsatellite status and its correlation with infiltrating immune cells in the tumor microenvironment

Objective: The microsatellite status and tumor immune microenvironment have a remarkable influence on tumor immunotherapy. This study was performed to investigate programmed cell death protein 1/programmed death ligand 1 (PD1/PDL1) expression and their correlations with CD8+ T cell/CD68+ macrophage (CD68+ M) densities in gastric cancer (GC) at different microsatellite statuses. Methods: The expression of MLH1, PMS2, MSH2, and MSH6 was detected via immunohistochemistry (IHC) to determine the microsatellite status in 215 GC samples obtained from surgical resections. Furthermore, the expression of PD1, PDL1, CD8, and CD68 was detected in the samples via IHC, and the differences and correlations in GC at different microsatellite statuses were then analyzed. PDL1 expression in tumor cells was labeled as PDL1[T], while expression of PD1 and PDL1 in tumor-infiltrating immune cells was labeled as PD1 and PDL1, respectively. Kaplan-Meier analysis was used to evaluate the significance of PD1/PDL1 expression in determining overall survival. Multivariate Cox regression analysis was performed using SPSS software. P-values were determined using the log-rank test. Results: Our results indicated that PD1, PDL1[T], and PDL1 positivity rates were 59%, 35%, and 57% in 46 microsatellite unstable (MSI) GCs and 45%, 22%, and 40% in 169 microsatellite stable (MSS) GCs, respectively. Compared with MSS GC, PD1, PDL1[T], and PDL1 expression was higher in MSI GC (P = 0.109, 0.090, and 0.044, respectively). Additionally, CD8+ T cell and CD68+ M densities were higher in MSI GC than in MSS GC (P = 0.537 and <0.001, respectively). Additionally, CD8+ T cell/CD68+ M densities were evaluated according to tumor center and invasion front. We found that PD1 expression was significantly correlated with CD8+ T cell density at the invasion front of the MSI GC (P = 0.031), whereas PDL1 expression was significantly correlated to high CD68+ M density in the tumor center and invasion front of MSS GC (P = 0.001 and 0.014, respectively). Survival analysis showed that patients with PD1-positive and PDL1[T]/PDL1-negative GC had better prognosis (P = 0.012, 0.005, and 0.022, respectively). Multivariate Cox survival analysis showed that PDL1[T] was an independent prognostic factor for GC. Conclusion: The results suggested that PD1/PDL1 expression and immune response varied at different microsatellite statuses in GC. PD1/PDL1 expression was correlated with CD8+ T cell/CD68+ M densities in GC at different microsatellite statuses, especially at the invasion front. The patients exhibiting high PD1/PDL1 expression or high CD8+ T cell/CD68+ M densities MSI GC might be potential beneficiaries of PD1/PDL1 immunotherapy.
Obesity and Overweight Are Independently Associated with Greater Survival in Critically Ill Diabetic Patients: A Retrospective Cohort Study

Background The relationship between obesity and the outcomes of critically ill diabetic patients is not completely clear. We aimed to assess the effects of obesity and overweight on the outcomes among diabetic patients in the intensive care unit (ICU). Methods Critically ill diabetic patients in the ICU were classified into three groups according to their body mass index. The primary outcomes were 30-day and 90-day mortality. ICU and hospital length of stay (LOS) and incidence and duration of mechanical ventilation were also assessed. Cox regression models were developed to evaluate the relationship between obesity and overweight and mortality. Results A total of 6108 eligible patients were included. The 30-day and 90-day mortality in the normal weight group were approximately 1.8 times and 1.5 times higher than in the obesity group and overweight group, respectively (P < 0.001, respectively). Meanwhile, the ICU (median (IQ): 2.9 (1.7, 5.3) vs. 2.7 (1.6, 4.8) vs. 2.8 (1.8, 5.0)) and hospital (median (IQ): 8.3 (5.4, 14.0) vs. 7.9 (5.1, 13.0) vs. 8.3 (5.3, 13.6)) LOS in the obesity group and overweight group were not longer than in the normal weight group. Compared with normal weight patients, obese patients had significantly higher incidence of mechanical ventilation (58.8% vs. 64.7%, P < 0.001) but no longer ventilation duration (median (IQ): 19.3 (7.0, 73.1) vs. 19.0 (6.0, 93.7), P = 1). Multivariate Cox regression showed that obese and overweight patients had lower 30-day (HR (95% CI): 0.62 (0.51, 0.75); 0.76 (0.62, 0.92), respectively) and 90-day (HR (95% CI): 0.60 (0.51, 0.70); 0.79 (0.67, 0.93), respectively) mortality risks than normal weight patients. Conclusions Obesity and overweight were independently associated with greater survival in critically ill diabetic patients, without increasing the ICU and hospital LOS. Large multicenter prospective studies are needed to confirm our findings and the underlying mechanisms warrant further investigation.
Large-scale layered systems and synthetic biology: model reduction and decomposition

This thesis is concerned with large-scale systems of Ordinary Differential Equations that model Biomolecular Reaction Networks (BRNs) in Systems and Synthetic Biology. It addresses the strategies of model reduction and decomposition used to overcome the challenges posed by the high dimension and stiffness typical of these models. A number of developments of these strategies are identified, and their implementation on various BRN models is demonstrated. The goal of model reduction is to construct a simplified ODE system to closely approximate a large-scale system. The error estimation problem seeks to quantify the approximation error; this is an example of the trajectory comparison problem. The first part of this thesis applies semi-definite programming (SDP) and dissipativity theory to this problem, producing a single a priori upper bound on the difference between two models in the presence of parameter uncertainty and for a range of initial conditions, for which exhaustive simulation is impractical. The second part of this thesis is concerned with the BRN decomposition problem of expressing a network as an interconnection of subnetworks. A novel framework, called layered decomposition, is introduced and compared with established modular techniques. Fundamental properties of layered decompositions are investigated, providing basic criteria for choosing an appropriate layered decomposition. Further aspects of the layering framework are considered: we illustrate the relationship between decomposition and scale separation by constructing singularly perturbed BRN models using layered decomposition; and we reveal the inter-layer signal propagation structure by decomposing the steady state response to parametric perturbations. Finally, we consider the large-scale SDP problem, where large scale SDP techniques fail to certify a system’s dissipativity. We describe the framework of Structured Storage Functions (SSF), defined where systems admit a cascaded decomposition, and demonstrate a significant resulting speed-up of large-scale dissipativity problems, with applications to the trajectory comparison technique discussed above.
Comparative study of the inhibitory effect of antidepressants on cholinesterase activity in Bungarus sindanus (krait) venom, human serum and rat striatum

Cholinesterases are divided into two classes based on differences in their substrate specificity and tissue distribution: acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). These enzymes may be inhibited by several compounds, such as antidepressants. The antidepressants paroxetine, imipramine, clomipramine and sertraline inhibited both venom AChE as well as human serum BChE in a concentration-dependent manner but had no effect on AChE in the rat brain striatum. The IC50 of venom calculated for imipramine was 0.3 mM, paroxetine 0.38 mM, clomipramine 0.34 mM and sertraline 0.35 mM. Analysis of kinetic data indicated that the inhibition caused by sertraline and paroxetine was mixed, i.e. Km values increased and Vmax decreased in a concentration dependent manner. Imipramine and clomipramine exhibited competitive inhibition, i.e. Km values increased and Vmax remained constant. The present results suggest that these therapeutic agents used for depression can also be considered as inhibitors of snake venom and human serum cholinesterase.
XPS characterization of PTFE after treatment with RF oxygen and nitrogen plasma

A study on surface modification of extended PTFE (polytetrafluoroethylene) foil after treatment in oxygen and nitrogen plasma is presented. PTFE was exposed to a weakly ionized, highly dissociated RF plasma with a high density of neutral atoms. The gas pressure was 75 Pa and the discharge power was 200 W. The appearance of the functional groups on the sample surface was determined by using high‐resolution XPS. The results showed that oxygen plasma treatment did not cause any noticeable changes in the surface composition, while after nitrogen plasma treatment new functional groups were detected on the surface. Copyright © 2008 John Wiley & Sons, Ltd.
Longitudinal Laminar Flow Between Cylinders Arranged in Regular Array

An analytical solution has been obtained for the longitudinal fully developed laminar flow between cylinders arranged in triangular or square array. Numerical results for the pressure drop and the friction factor are given over a wide range of spacing-to-diameter ratios. For large spacings the results can be represented by a single expression independent of the type of array. Plots are also given of velocity distributions and of the variation of the local shear stress around the periphery of a cylinder.
Response Surface Methodology for Optimization of Glucuronic Acid Production Using Kombucha Layer on Sour Cherry Juice

The optimum conditions for the glucuronic acid production (the important key component for its detoxifying action through conjugation to the xenobiotic metabolism of the substances in liver) using kombucha layer on sweetened sour cherry juice were determined using response surface methodology. Kombucha layer involving a symbiosis of osmophilic yeast species and acetic acid bacteria that convert a very simple substrate to a slightly carbonated, acidic, refreshing beverage with high pharmaceutical and nutritional value. A central composite rotatable design, consisting of seventeen experiments was used to investigate the effects of three independent variables, namely sucrose content, temperature and the cultivation time on five responses: glucuronic acid (g/L), pH value, remained sucrose (g/L), reducing sugar (g/L), and total acidity (g/L). Statistical analysis of the obtained results, depicted that all the factors had a significant effect which leads to glucuronic acid concentration upto maximum 132.5 g/L at 37 °C within two weeks of fermentation process on 8% sucrose-sweetened sour cherry juice.
Benzimidazole–carbazole-based bipolar hosts for high efficiency blue and white electrophosphorescence applications

A series of novel bipolar blue phosphorescent host materials mBICP, mBINCP and mBIPhCP have been designed and synthesized, which comprehensively outperform the widely used phosphorescent host, 1,3-di(9H-carbazol-9-yl)benzene (mCP). The thermal, photophysical and electrochemical properties of these host materials were finely tuned through linking different carbazole moieties to the benzimidazole. mBICP (Tg = 84 °C) and mBIPhCP (Tg = 103 °C) exhibit high morphological stabilities in comparison with mCP. Theoretical calculations show that the HOMO/LUMO orbitals of these materials are mainly dispersed on the electron donating and electron accepting groups, respectively. A blue PhOLED device fabricated using mBICP as the host exhibits a maximum external quantum efficiency (ηEQE,max) of 18.7% and a maximum power efficiency (ηP,max) of 33.6 lm W−1. Interestingly, the external quantum efficiencies (ηEQE) are still as high as 17.1% at a high luminance of 1000 cd m−2. Furthermore, the two-color, all-phosphor and single-emitting-layer white device hosted by mBICP achieved a maximum external quantum efficiency (ηEQE,max) of 20.5% corresponding to a maximum power efficiency (ηP,max) of 53.3 lm W−1.
Determination of modifiable risk factors for length-for-age z-scores among resource-poor Indonesian infants

To reduce the burden of early-life linear growth faltering in low- and middle-income countries, interventions have focused on nutrition strategies, sometimes combined with water quality, sanitation, and hygiene (WASH). However, even when combined, their effects on linear growth have been inconsistent. Here, we investigate potential predictors of length-for-age z-scores (LAZ) in a cohort of resource-poor rural Indonesian infants to inform the optimal strategies to reduce linear growth faltering. Apparently healthy rural breastfed Indonesian infants were randomly selected from birth registries at age 6 months (n = 230) and followed up at 9 (n = 202) and 12 (n = 190) months. Using maximum likelihood estimation, we examined longitudinal relationships among socio-demographic status, maternal height, infant sex, age, water source, sanitation facility, energy, protein, micronutrient intakes and biomarkers (serum ferritin, zinc, retinol binding protein (RBP), selenium–adjusted for inflammation), and α-1-acid glycoprotein (AGP) and C-reactive protein (CRP) (systemic inflammation biomarkers) at age 6 and 9 months on LAZ at age 9 and 12 months. Stunting (LAZ <-2) at 6, 9, and 12 months was 15.7%, 19.3%, and 22.6%, respectively. In the full model, the predictor variable at age 6 months that was most strongly associated with infant LAZ at 9 months was maternal height (0.18 (95% CI 0.03, 0.32) SD). At age 9 months, the strongest predictors of LAZ at 12 months were improved drinking water source (-0.40 (95% CI -0.65, -0.14) vs. not improved), elevated AGP compared to not elevated (0.26 (95%CI -0.06, 0.58), maternal height (0.16 (95% CI 0.02, 0.31) SD), sex (0.22 (95% CI -0.02,0.45) female vs. male), serum RBP (0.12 (95% CI -0.01, 0.25) SD), and protein intake (0.17 (95% CI -0.01, 0.35) SD). Health promotion that includes exclusive breastfeeding up to the first six months and follows microbial water quality guidelines to ensure water intake is always safe should be considered.
BIOSORPTION OF LEAD, COPPER, AND CADMIUM WITH CONTINUOUS HOLLOW-FIBER MICROFILTRATION PROCESSES

Abstract A hollow-fiber crossflow microfiltration membrane was utilized to retain a biomass of Pseudomonas aeruginosa PU21 for continuous biosorption of lead (Pb), copper (Cu), and cadmium (Cd) ions in single or ternary metal systems. The results obtained from the microfiltration systems showed that in both single and ternary biosorption, the metal removal efficiency based on a molar basis was clearly Pb > Cu > Cd. For a single-membrane process with an influent metal concentration of 200 μM and a flow rate of 350 mL/h, the effluent concentration of Pb and Cu satisfied the national regulations for an influent volume of 6.3 L. With a three-metal influent, the adsorption capacity of the biomass for Pb, Cu, and Cd was reduced 4,50, and 74% compared to that for single-metal adsorption. Selective biosorption with a three-column sequential microfiltration operation exhibited an enhancement of 40 and 57% of total metal removal for Cu and Cd, respectively, over the results from single-membrane operation. The multi.
The Effect of Social Media on Stress among Young Adults during COVID-19 Pandemic: Taking into Account Fatalism and Social Media Exhaustion

ABSTRACT Social media has been widely used as an important source of health information, particularly during public health crises. However, findings regarding social media’s impact on young adults’ mental health are mixed. There is a need to identify social mechanisms underlying the effect of social media on mental health outcomes. Our study breaks new ground by proposing and testing a moderated mediation pathway from social media use to stress in young adults during the COVID-19 pandemic. We conducted a two-wave online panel survey in the context of China. With a general basis of the Street’s three-stage model, our results indicated that social media failed to directly affect young adults’ stress. Instead, fatalism completely mediated this relationship. Also, one’s perceived social media exhaustion negatively moderated this mediation pathway. The findings have significant theoretical and practical implications for the use of social media to promote health, well-being, and quality of life among young people during public health crises.
Re-evaluation of potential predictors of calretinin and mesothelin in a population-based cohort study using assays for the routine application in clinical medicine

Objectives Calretinin and mesothelin are molecular markers for the detection of malignant mesothelioma at early stages. Our objective was the re-evaluation of factors influencing calretinin and mesothelin concentrations in plasma of cancer-free men in order to minimise false-positive tests when using commercial assays approved for clinical diagnostics. Setting This re-evaluation used data and archived blood samples of the population-based Heinz Nixdorf Recall Study (HNRS) collected from 2011 to 2014. Participants The present analysis comprised of 569 cancer-free men at the time of blood sampling (median age 70 years) from HNRS. Primary and secondary outcomes Mesothelin plasma concentration was determined using ELISA and CLEIA (chemiluminescent enzyme immunoassay). Calretinin plasma concentration was assessed using ELISA. Results Compared with the previous determination of concentrations, we detected less false-positive tests using the commercial assays. In this analysis, we found nine false-positive calretinin tests using the ELISA (specificity 98.4%, 95% CI 97.0% to 99.2%) and 24 false-positive mesothelin tests using both ELISA and CLEIA (specificity 95.8%, 95% CI 93.8% to 97.2%). We confirmed renal dysfunction as major predictor of elevated marker concentrations. Mesothelin was additionally affected by bronchitis. Furthermore, elevated inflammation values and hypertension only affected the mesothelin concentration determined by ELISA. Conclusions The newly available assays of calretinin and mesothelin approved for clinical diagnostics showed high specificities in the population-based cohort of elderly men without a malignant disease. The current evaluation provides a basis to consider influencing factors in order to further improve the diagnostic procedure.