Miracle-dz/UniFAR-FTUs huggingface dataset:
Got Mylk? The Emerging Role of Australian Plant-Based Milk Alternatives as A Cow’s Milk Substitute

Growing ethical, environmental and health concerns have encouraged demand for novel plant-based milk alternatives, yet it remains nebulous whether these products are nutritionally adequate as cow’s milk replacements. The aim of this study was to conduct a cross-sectional survey of plant-based milk alternatives available in major Australian supermarkets and selected niche food retailers from November 2019 to January 2020 and assess two dietary scenarios (adolescents and older women) where dairy serves were substituted for plant-based alternatives against Australian Estimated Average Requirements (EAR). We collected compositional data from nutrition panels in juxtaposition with derivatives from the Australian Food Composition database, with a total of 115 products, including tree nuts and seeds (n = 48), legumes (n = 27), coconut (n = 10), grains (n = 19) and mixed sources (n = 10). Just over 50% of products were fortified, but only 1/3 contained similar calcium content to cow’s milk. Indiscriminate substitutions might reduce intakes of protein and micronutrients, particularly vitamin A, B2, B12, iodine and zinc, and lead to reductions >50% of the EARs for protein, zinc and calcium in the chosen dietary scenarios. To avoid unintended dietary outcomes, it is vital that consumers make pragmatic decisions regarding dietary replacements for cow’s milk.
A Survey of Bowfishing Tournaments in Arkansas

Abstract Bowfishing is an understudied method of fishing that appears to be legal throughout the United States. Therefore, species composition and harvest rates were determined at six bowfishing tournaments held in Arkansas at the lower White River, the Arkansas River at Lake Dardanelle, the Arkansas River at Piney Bay, Lake DeGray, Bull Shoals Lake, and Lake Ouachita between July 1999 and May 2000. A total of 3,280 fish were harvested at the six tournaments; of this total, 2,751 fish representing 19 species were identified. Total harvest per tournament ranged from 179 to 1,674 fish and from 6 to 12 species. Mean (±SD) harvest rate for tournament participants was 3.8 ± 1.1 fish/h; among tournament winners, the harvest rate was 7.7 ± 2.8 fish/h, which appears high compared with other sport fisheries (range = 0.28–2.59 fish/h). Five species accounted for 84% of fish harvested: spotted gar Lepisosteus oculatus, common carp Cyprinus carpio, shortnose gar L. platostomus, spotted sucker Minytrema melanops, and .
The Prevalence of Abnormalities in the Pediatric Spine on MRI: A Systematic Review and Meta-Analysis.

STUDY DESIGN Systematic review and meta-analysis. OBJECTIVE To provide an overview of the prevalence of reported musculoskeletal abnormalities on magnetic resonance imaging (MRI) of the pediatric spine. SUMMARY OF BACKGROUND DATA Back pain is a common complaint and significant health issue, already in children. Several studies have investigated musculoskeletal abnormalities of the pediatric spine as possible cause of low back pain (LBP). However, it is not clear which abnormalities are the most prevalent among children. METHODS A systematic literature search on the prevalence of musculoskeletal spinal abnormalities on MRI in children was conducted in the Embase, Medline Ovid and Cochrane CENTRAL databases. Risk of bias was assessed using a checklist based on the Downs and Black checklist. General information on study and patient characteristics and the prevalence of spinal abnormalities were extracted from the studies. Prevalence data was presented in three subgroups: non-athletes without low back pain, participants with low back pain, and athletes. Prevalence data of the most reported abnormalities were pooled using random-effects proportion meta-analysis. The study protocol was prospectively registered in PROSPERO (CRD42017080543). RESULTS The search resulted in 16,783 articles, of which 31 articles (2,373 participants) were included in this systematic review. Two third of the studies had a low risk of bias. The pooled prevalence in non-athletes without LBP, participants with LBP, and athletes without LBP was respectively 22%, 44% and 22% for disc degeneration, 1%, 38% and 13% for herniated discs, 5%, 22% and 11% for endplate changes, and 0%, 30% and 6% for pars fractures. CONCLUSIONS Disc degeneration, herniated discs, endplate changes, and spondylolysis are the most reported spinal abnormalities on MRI in children in literature. Spinal abnormalities seen in adults are already prevalent in children with LBP, with the highest prevalence for disc degeneration and herniated discs. LEVEL OF EVIDENCE 2.
Natural diets of zooplankton off southern California

Plant and animal carotenoid pigments were isolated from the guts of the copepods Calanus pacificus and Clausocalanus sp, and the cladocerans Evadne spp. by high performance Liquid chromatography. Measured carotenoid concentrations were converted to eshmates of class-specific phytoplankton biomass and total microzooplankton biomass In the zooplankton diets. Different pigments were present in the guts at dfferent times of day and night and the tllnmg of peak gut fullness var~ed between species. In C. pacificus, pigment concentrat~ons were highest during the period from evening twilight to midnight. Evadne spp. exhibited a midnight peak In gut pigmentation. Clausocalanus sp. contained elevated levels of pigments between midnight and noon. The gut contents of C. pacificus and Evadne spp. were dominated by animal carbon when phytoplankton biomass and productivity were relatively low, and by algal carbon when phytoplankton biomass and productivity were high. Clausocalanus sp. did not follow this pattern. Our observations are consistent with the hypothesis that carnivory may represent an important mode of feeding among small zooplankton and, further, that the diets of some species of zooplankton vary in response to quantitative and qualitative attributes of the food environment.
Video Captioning With Object-Aware Spatio-Temporal Correlation and Aggregation

Video captioning is a significant challenging task in computer vision and natural language processing, aiming to automatically describe video content by natural language sentences. Comprehensive understanding of video is the key for accurate video captioning, which needs to not only capture the global content and salient objects in video, but also understand the spatio-temporal relations of objects, including their temporal trajectories and spatial relationships. Thus, it is important for video captioning to capture the objects’ relationships both within and across frames. Therefore, in this paper, we propose an object-aware spatio-temporal graph (OSTG) approach for video captioning. It constructs spatio-temporal graphs to depict objects with their relations, where the temporal graphs represent objects’ inter-frame dynamics, and the spatial graphs represent objects’ intra-frame interactive relationships. The main novelties and advantages are: (1) Bidirectional temporal alignment: Bidirectional temporal graph is constructed along and reversely along the temporal order to perform bidirectional temporal alignment for objects across different frames, which provides complementary clues to capture the inter-frame temporal trajectories for each salient object. (2) Graph based spatial relation learning: Spatial relation graph is constructed among objects in each frame by considering their relative spatial locations and semantic correlations, which is exploited to learn relation features that encode intra-frame relationships for salient objects. (3) Object-aware feature aggregation: Trainable VLAD (vector of locally aggregated descriptors) models are deployed to perform object-aware feature aggregation on objects’ local features, which learn discriminative aggregated representations for better video captioning. A hierarchical attention mechanism is also developed to distinguish contributions of different object instances. Experiments on two widely-used datasets, MSR-VTT and MSVD, demonstrate our proposed approach achieves state-of-the-art performances in terms of BLEU@4, METEOR and CIDEr metrics.
Darvadstrocel for the treatment of perianal fistulas in Crohn’s disease

ABSTRACT Introduction Perianal fistulizing Crohn’s disease is associated with a poor quality of life and current medical and surgical treatment options are limited. Darvadstrocel, composed of mesenchymal stem (stromal) cells (MSC), has recently been approved by the European Medicines Agency (EMA) for the treatment for perianal disease. This drug profile educates the reader with this novel treatment approach. Areas covered A literature search was performed on PubMed with focus on perianal fistulizing Crohn’s disease and mesenchymal stem (stromal) cells. This review summarizes evidence of the current standard of care and discusses the mechanism of action, manufacturing, and application and safety of darvadstrocel. Expert Opinion Darvadstrocel is a safe and effective therapy for complex perianal fistulizing Crohn’s disease.
The Role of Imaging in the Detection and Management of COVID-19: A Review

Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is spreading rapidly around the world, resulting in a massive death toll. Lung infection or pneumonia is the common complication of COVID-19, and imaging techniques, especially computed tomography (CT), have played an important role in diagnosis and treatment assessment of the disease. Herein, we review the imaging characteristics and computing models that have been applied for the management of COVID-19. CT, positron emission tomography - CT (PET/CT), lung ultrasound, and magnetic resonance imaging (MRI) have been used for detection, treatment, and follow-up. The quantitative analysis of imaging data using artificial intelligence (AI) is also explored. Our findings indicate that typical imaging characteristics and their changes can play crucial roles in the detection and management of COVID-19. In addition, AI or other quantitative image analysis methods are urgently needed to maximize the value of imaging in the management of COVID-19.
Bioenergetics Modeling of Stream Trout Growth: Temperature and Food Consumption Effects

Abstract We investigated bioenergetics modeling of growth as an approach for assessing the effects of temperature changes on stream dwelling rainbow trout Oncorhynchus mykiss. Study objectives were (1) to determine the relative effect of temperature versus food consumption on model-predicted growth and (2) to identify relationships between model-predicted food consumption and commonly measured environmental variables. A bioenergetics model for rainbow trout was calibrated to apparent age-1 growth in summer and fall–spring periods for 10 years at eight Sierra Nevada, California, study sites. Model analyses showed that the observed year-to-year variation in summer growth was related to food consumption but not to temperature and that temperature was more important, but still of secondary importance, to observed variation in fall–spring growth. Growth at all sampling sites appeared lower and more variable in summer than in other seasons, and variation among sites and years in the food consumption parameter P.
Phosphorus fractionation in lake sediments

The influence of reagent concentration, extraction time, and lithological composition of sediment samples on the concentration and composition of the extracted phosphorus fractions was examined. Good reproducibility was achieved for dry samples. The proportions of P fractions were found to depend on the texture of lake sediments, which speaks about an essential role of cohesivity of sediments and sorption of phosphorus in the sediment flocs. The NaOH-P concentration was higher in the samples with a high silt content. Extraction duration did not influence the concentration of metal oxide bound P extraction with a low (0.1 M) NaOH concentration. The total P concentration showed a significant positive correlation with silt (r = 0.897), organic matter (r = 0.564), and carbonate content (r = 0.546). Sedimentary inorganic P in the studied sediments consisted mainly of HCl-P, while NaOH-P and NH4Cl-P constituted only a minor part.
Effect of quebracho tannin on faecal egg counts and worm burdens of temperate sheep with challenge nematode infections

Three animal experiments were carried out to investigate the effect of condensed tannins (CT) on parasitic gastrointestinal (GI) nematode infections of sheep. Experiment 1 investigated the long-term effect of varying dietary levels (0–80 g/kg diet) of quebracho tannin (QT) on faecal egg counts (FEC) and feed consumption of lambs with experimental Haemonchus contortus infection. Dietary QT did not cause significant reductions in FEC although at high inclusions of QT there was an indication of a reduction in FEC. Some undesirable effects of tannins were also observed; feed consumption was significantly reduced (P<0·001) by dietary QT, while faecal water content increased significantly (P<0·01). In order to reduce the undesirable effects of dietary tannins in the host, short-term exposure to tannins was adopted. QT was administered as a drench, for 3 consecutive days, to growing lambs infected with H. contortus (Experiment 2) or its mixed infection with Trichostrongylus colubriformis (Experiment 3) and its effect on FEC, worm burdens and the GI tract was investigated. Administration of QT drench to sheep infected with the abomasal H. contortus alone significantly (P<0·05) reduced FEC and worm burdens (P<0·01) compared with the control group. In Experiment 3 the drench had little effect (P>0·05) on small intestinal T. colubriformis although similar effects to those seen in Experiment 2 on H. contortus were observed, suggesting that the location of the nematodes in the gut might be important. Apart from reducing feed consumption, the drench caused some physiological changes in the gut, particularly an increase in faecal water and mucus content, which were more marked following the drench than seen in the dietary inclusion trial. In conclusion, unlike dietary inclusion, QT worked more quickly and more effectively against H. contortus when administered as drench; T. colubriformis may require a higher dose or a prolonged exposure to the drench. The present findings suggest that it may be possible, perhaps with limited use of synthetic anthelmintics, to design appropriate feeding strategies using tannins to alleviate the problem of nematode infections in small ruminants. This may be particularly relevant to the tropics and subtropics where many species of plants contain high levels of tannins and where extracts high in tannins are readily available.
CD4+ T helper 17 cell response of aged mice promotes prostate cancer cell migration and invasion

Aging is the most important risk factor for prostate cancer (PCa), but how age contributes to PCa is poorly understood. Aging is characterized by low‐grade systemic inflammation (i.e., inflammaging) that is often attributed to the progressive activation of immune cells over time, which may play an important role in prostate carcinogenesis. Th17 response is elevated in aging humans and mice, but it remains unknown whether it is increased in prostate tissue or contributes to prostate carcinogenesis during aging. In this study, we aimed to determine the role of age‐related Th17 response in PCa cell growth, migration, and invasion.
Mycoplasma Co-Infection Is Associated with Cervical Cancer Risk

Tanzania faces one of the highest cervical cancer burdens in the world. Recent work has suggested that the bacterial family Mycoplasmataceae is associated with higher levels of human papillomavirus (HPV), human immunodeficiency virus (HIV), and pre-cancerous cervical lesions. Mycoplasmataceae infection in Tanzania is not well understood, especially when considering the differences between sexually transmitted species of Mycoplasmataceae. To establish the prevalence of common Mycoplasmataceae cervical infections and evaluate their relationship with risk factors for cervical cancer, 1160 Tanzanian women responded to an epidemiological questionnaire and were tested for HIV, HPV, cervical lesions, Mycoplasma genitalium, Mycoplasma hominis, Ureaplasma spp. , and Lactobacillus iners. A subset of 134 women were used for 16s metagenomic sequencing of cervical DNA to establish the relative abundance of Mycoplasmataceae and Lactobacillus present. PCR detection of bacteria at the cervix found Ureaplasma spp. in 51.4% of women, M. hominis in 34%, M. genitalium in 2.3%, and L. iners in 75.6%. M. hominis and M. genitalium infection were significantly more prevalent among women with HPV and HIV. M. hominis prevalence was similar despite severity of cervical lesions; however, abundance of M. hominis increased significantly in women with cervical lesions. These results emphasize the importance of understanding the relationship between M. hominis and HPV-related cervical pathogenesis.
Stromal cell-derived factor 1 regulates in vitro sperm migration towards the cumulus-oocyte complex in cattle

Sperm migration towards an oocyte in the female reproductive tract is an important step for successful fertilization. Although several sperm-chemotactic factors have been identified in mammals, it is unclear whether these chemoattractants contribute to sperm migration towards an oocyte that is the final destination for sperm. Furthermore, chemoattractants for bovine sperm are still undiscovered even though the follicular fluid attracts sperm in cattle. Here, we demonstrated that a single bovine cumulus-oocyte complex (COC) had the ability to attract sperm, suggesting that the COC secreted sperm chemoattractants. We identified stromal cell-derived factor 1 (SDF1), which was expressed in COCs, and its receptor CXCR4 in sperm, as a candidate. Our results showed that bovine sperm preferentially migrated to the area with a high SDF1 concentration and occasionally showed turn movements by asymmetric flagellar bends during the migration. We also demonstrated that increasing the intracellular Ca2+ concentration via Ca2+ channels was related to SDF1-induced sperm chemotaxis. Finally, a CXCR4 inhibitor significantly suppressed the in vitro bovine sperm migration towards a COC. Taken together, we propose that SDF1 is a chemotactic factor for bovine sperm to regulate their migration towards an oocyte via the CXCR4 receptor.
Identification of Tsetse Attractants from Excretory Products of a Wild Host Animal, Syncerus caffer

Urine from the buffalo, Syncerus caffer, a natural host of the tsetse, has been shown previously to be a potent olfactory attractant for tsetse in the field. The attractant compounds have been found to be extractable into dichloromethane. Fractionation of the extracts by liquid flash chromatography yielded four fractions one of which gave a seven-fold increase in trap catches in the field compared to the control traps. Gas chromatographic and gas chromatography-mass spectrometric analysis of this fraction revealed the presence of seven simple phenols including phenol itself. RésuméL’urine de buffle, Syncerus caffer, un hôte naturel de mouche tsé-tsé, s’est récement montré d’être un attracteur potentiel d’olfaction pour la mouche tsé-tsé sur le terrain. Les composés de cet attracteur ont été trouvés extractable dans le dichlorométhane. Le fractionnement de ces extraits par le liquide chromatographique a donné quatre fractions dont l’une d’elles, placée dans les pièges de capture a permis de récolter sept fois plus de mouches que les pièges-contrôles. L’analyse de cette fraction par gaz chromatographique et par gaz chromatographique associé à la masse spectrométrique a révelé la présence de sept phénols simple comprenant le phénol lui-même.
Sarcopenia in Neurological Patients: Standard Values for Temporal Muscle Thickness and Muscle Strength Evaluation

Temporal muscle thickness (TMT) was investigated as a novel surrogate marker on MRI examinations of the brain, to detect patients who may be at risk for sarcopenia. TMT was analyzed in a retrospective, normal collective cohort (n = 624), to establish standard reference values. These reference values were correlated with grip strength measurements and body mass index (BMI) in 422 healthy volunteers and validated in a prospective cohort (n = 130) of patients with various neurological disorders. Pearson correlation revealed a strong association between TMT and grip strength (retrospective cohort, ρ = 0.746; p < 0.001; prospective cohort, ρ = 0.649; p < 0.001). A low or no association was found between TMT and age (retrospective cohort, R2 correlation coefficient 0.20; p < 0.001; prospective cohort, ρ = −0.199; p = 0.023), or BMI (retrospective cohort, ρ = 0.116; p = 0.042; prospective cohort, ρ = 0.227; p = 0.009), respectively. Male patients with temporal wasting and unintended weight loss, respectively, showed significantly lower TMT values (p = 0.04 and p = 0.015, unpaired t-test). TMT showed a high correlation with muscle strength in healthy individuals and in patients with various neurological disorders. Therefore, TMT should be integrated into the diagnostic workup of neurological patients, to prevent, delay, or treat sarcopenia.
Genetic testing costs and compliance with clinical best practices

We sought to determine the costs of genetic testing and compliance with published guidelines and clinical best practices at our institution. A cost analysis was performed comparing the costs of ordered tests to the cost of the recommended testing. This was an approved quality improvement project at a tertiary teaching hospital in California. We identified charts associated with the genetic testing billing codes for common genetic tests through our contracted laboratory (cystic fibrosis genotyping, Breast cancer susceptibility gene (BRCA 1&2), Methylenetetrahydrofolate reductase (MTHFR), factor V Leiden (FVL), prothrombin gene pathogenic variant, alpha‐thalassemia, hemochromatosis, and cell‐free fetal DNA). Charts were reviewed retrospectively by a licensed, certified genetic counselor to assess the compliance with published clinical practice guidelines identified on GeneReviews and the American College of Obstetricians and Gynecologists (ACOG). Tests were classified as: appropriate, misordered/not indicated, misordered/false reassurance, and misordered/inadequate. We performed a cost analysis for the recommended test changes. We reviewed 114 charts over a three‐month period. Forty‐four (38.6%) of the tests were misordered based on published clinical practice guidelines: 24 (21%) were misordered/not indicated, 8 (7%) were misordered/false reassurance, and 12 (10.5%) were misordered/inadequate. Costs of ordered testing ($75,177) were compared to recommended testing after review ($54,265), with a total cost savings of $20,912. In clinical practice, over one‐third of genetic tests reviewed were misordered. As these tests are a small fraction of all genetic tests at our institution, future studies should broaden the scope of testing evaluated to understand the magnitude of this problem and potential cost savings. Genetic counselor review and involvement in genetic test ordering can decrease inappropriate healthcare expenditures and improve patient care.