Miracle-dz/UniFAR-FTUs huggingface dataset:
A Theory of Coordination in Agile Software Development Projects

Agile software development offers a deceptively simple means to organise complex multi-participant software development while achieving fast delivery of quality software, meeting customer requirements, and coping effectively with project change. There is little understanding, however, of how agile software development projects achieve effective coordination, a critical factor in successful software projects. Agile software development provides a unique set of practices for organising the work of software projects, and these practices seem to achieve effective project coordination. Therefore, this thesis takes a coordination perspective to explore how agile software projects work, and why they are effective. The outcome of this research is a theory of coordination in co-located agile software development projects. To build a coordination theory, evidence was drawn from a multi-case study following the positivist tradition in information systems. Three cases of agile software development contributed to the theory, along with one additional non-agile project that contributed contrasting evidence. The findings show that agile software development practices form a coordination strategy addressing three broad categories of dependency: knowledge dependencies, task dependencies, and resource dependencies. Most coordination is for managing requirement, expertise, historical, and task allocation dependencies; all forms of knowledge dependency. Also present are task dependencies, which include activity or business process dependencies, and resource dependencies, which include technical or entity dependencies. The theory of coordination explains that an agile coordination strategy consists of coordination mechanisms for synchronising the project team, for structuring their relations, and for boundary spanning. A coordination strategy contributes to coordination effectiveness, which has explicit and implicit components. The primary contribution of this theory is an explanation of how agile software development practices act together to achieve effective project coordination. The coordination strategy concept can be used to select practices from agile methods to ensure software projects achieve effective coordination. In addition, once operationalised in future work, the well-grounded theoretical concepts developed in this research will provide valuable tools for measuring the coordination effectiveness of agile method adoption and adaptation.
Pure Tone Audiometry Evaluation Method Effectiveness in Detecting Hearing Changes Due to Workplace Ototoxicant, Continuous Noise, and Impulse Noise Exposures

Objectives: The purpose of this retrospective cohort study was to compare the relative risks (RR) of hearing impairment due to co-exposure of continuous noise, impulse noise, metal ototoxicants, and organic solvent ototoxicants using several pure tone audiometry (PTA) evaluation methods. Design: Noise and ototoxicant exposure and PTA records were extracted from a DoD longitudinal repository and were analyzed for U.S. Air Force personnel (n = 2372) at a depot-level aircraft maintenance activity at Tinker Air Force Base, Oklahoma using an historical cohort study design. Eight similar exposure groups based on combinations of ototoxicant and noise exposure were created: (1) Continuous noise (reference group); (2) Continuous noise + Impulse noise; (3) Metal exposure + Continuous noise; (4) Metal exposure + Continuous noise + Impulse noise; (5) Solvent exposure + Continuous noise; (6) Solvent exposure + Continuous noise + Impulse noise; (7) Metal exposure + Solvent exposure + Continuous noise; and (8) Metal exposure + Solvent exposure + Continuous noise + Impulse noise. RR of hearing impairment compared to the Continuous noise-exposed reference group was assessed with five PTA evaluation methods including (1) U.S. Department of Defense (DoD) Significant Threshold Shift (STS), (2) Occupational Safety and Health Administration (OSHA) age-adjusted STS, (3) National Institute for Occupational Safety and Health (NIOSH) STS, (4) NIOSH Material Hearing Impairment, and (5) All Frequency Threshold Average. Results: Hearing impairment was significantly worse for SEG (2) combined exposure to continuous noise and impulse noise only for the PTA evaluation method (2) OSHA Age Adjusted with an RR of 3.11, [95% confidence interval (CI), 1.16–8.31] and was nearly significantly different using PTA evaluation method (4) NIOSH Material Hearing Impairment with an RR of 3.16 (95% CI, 0.99–10.15). Despite no significant differences for SEGs with an ototoxicant exposure, PTA evaluation method (3) NIOSH STS was most sensitive in detecting hearing changes for SEG (8) Metal exposure + Solvent exposure + Continuous noise + Impulse noise as demonstrated by a RR of 1.12 (95% CI, 0.99–1.27). Conclusions: Results suggest that a single PTA evaluation technique may not be adequate in fully revealing hearing impairment risk due to all stressors and tailoring the PTA evaluation technique to the hazards present in the workplace could better detect hearing impairment. Additionally, results suggest that PTA may not be effective as the sole technique for evaluating hearing impairment due to ototoxicant exposure with continuous noise co-exposure.
The best choice of induction chemotherapy for patients with locally advanced nasopharyngeal carcinoma: Bayesian network meta‐analysis

The determination of the optimal induction chemotherapy (IC) regimen for patients with locally advanced nasopharyngeal carcinoma (NPC) remains controversial. Eligible trials included in this Bayesian network meta‐analysis were judged by synthetically evaluating survival and safety outcomes. The analysis revealed that the combined IC regimen of gemcitabine plus cisplatin (GP) gained not only the most favorable overall survival (OS) benefit but also longer distant metastasis‐free survival and manageable adverse events (AEs). Additionally, combination IC regimen of mitomycin, epirubicin, cisplatin, fluorouracil, and leucovorin had insufficient significant efficacy on complete response. Docetaxel combined with cisplatin and fluorouracil induction regimen provided the first exact probability of efficacy in term of local recurrence‐free survival, ranking second in OS, but accompanied by the highest rates of grade 3 or above AEs. GP regimen appears to be currently the best choice of IC regimen for combined benefit of patients with locally advanced NPC.
Persistence of ctDNA in Patients with Breast Cancer During Neoadjuvant Treatment Is a Significant Predictor of Poor Tumor Response

Abstract Purpose: Accurate response assessment during neoadjuvant systemic treatment (NST) poses a clinical challenge. Therefore, a minimally invasive assessment of tumor response based on cell-free circulating tumor DNA (ctDNA) may be beneficial to guide treatment decisions. Experimental Design: We profiled 93 genes in tissue from 193 patients with early breast cancer. Patient-specific assays were designed for 145 patients to track ctDNA during NST in plasma. ctDNA presence and levels were correlated with complete pathological response (pCR) and residual cancer burden (RCB) as well as clinicopathologic characteristics of the tumor to identify potential proxies for ctDNA release. Results: At baseline, ctDNA could be detected in 63/145 (43.4%) patients and persisted in 25/63 (39.7%) patients at mid-therapy (MT) and 15/63 (23.8%) patients at the end of treatment. ctDNA detection at MT was significantly associated with higher RCB (OR = 0.062; 95% CI, 0.01–0.48; P = 0.0077). Of 31 patients with detectable ctDNA at MT, 30 patients (96.8%) were nonresponders (RCB II, n = 8; RCB III, n = 22) and only one patient responded to the treatment (RCB I). Considering all 145 patients with baseline (BL) plasma, none of the patients with RCB 0 and only 6.7% of patients with RCB I had ctDNA detectable at MT, whereas 30.6% and 29.6% of patients with RCB II/III, respectively, had a positive ctDNA result. Conclusions: Overall, our results demonstrate that the detection and persistence of ctDNA at MT may have the potential to negatively predict response to neoadjuvant treatment and identify patients who will not achieve pCR or be classified with RCB II/III.
Intelligent Event-Based Fuzzy Dynamic Positioning Control of Nonlinear Unmanned Marine Vehicles Under DoS Attack

This article addresses the dynamic positioning control problem of a nonlinear unmanned marine vehicle (UMV) system subject to network communication constraints and deny-of-service (DoS) attack, where the dynamics of UMV are described by a Takagi–Sugeno (T-S) fuzzy system (TSFS). In order to save limited communication resource, a new intelligent event-triggering mechanism is proposed, in which the event triggering threshold is optimized by a $Q$ -learning algorithm. Then, a switched system approach is proposed to deal with the aperiodic DoS attack occurring in the communication channels. With a proper piecewise Lyapunov function, some sufficient conditions for global exponential stability (GES) of the closed-loop nonlinear UMV system are derived, and the corresponding observer and controller gains are designed via solving a set of matrix inequalities. A benchmark nonlinear UMV system is adopted as an example in simulation, and the simulation results validate the effectiveness of the proposed control method.
The role of melatonin in the molecular mechanisms underlying metaflammation and infections in obesity: A narrative review

Obesity is a chronic condition whose management is a critical challenge for physicians. The scientific community has increased its focus on the molecular mechanisms involved in obesity etiopathogenesis to better manage patients with obesity and its associated complications. The tight connection between adipose tissue and the immune system has been demonstrated to play a crucial role in inflammation, and melatonin is important for circadian rhythm regulation and metabolic homeostasis, in which it orchestrates several molecular mechanisms involved in obesity and associated inflammation. Melatonin also regulates innate and adaptive immunity; its antioxidant properties are linked to reduced predisposition to infection and weight gain in patients with obesity through the modulation of the immune response, which has a significant beneficial effect on inflammation and, consequently, on the metabolic state. Low melatonin levels have been linked to obesity, and melatonin supplementation can reduce body weight, improve metabolic profile, and ameliorate immune responses and pro‐inflammatory stimuli. The role of melatonin in obesity is mainly related to improved oxidative stress signaling, modulation of adipokine secretion, and a switching from white‐to‐brown adipose tissue phenotype and activity. Moreover, the role of melatonin in obesity modulation by controlling circadian rhythm has recently emerged as a pivotal mechanism for lipid and glucose metabolism dysfunction in adipose, muscle, and liver tissues. Melatonin may also regulate the immune system by acting directly on thymus morphology and activity as well as by modulating oxidative stress and inflammatory states during infections. The tight association between melatonin and immune response regulation is coordinated by Toll‐like receptors, which are rhythmically expressed during the day. Their expression may be strongly modulated by melatonin as their signaling is highly inhibited by melatonin. The current review summarizes studies of melatonin‐induced mechanisms involved in infection regulation, particularly the modulation of obesity‐associated inflammation and systemic complications.
Effects of interface material on the performance of free rocking blocks

This paper presents the results of an experimental investigation on the rocking behavior of rigid blocks. Two types of test specimens have been tested, namely M and C types. Nine blocks of the M type and two blocks of the C type with different aspect ratios were tested with varying initial rotational amplitudes and with different materials at the contact interface, namely concrete, timber, steel, and rubber. The results showed that the interface material has significant influence on the free rocking performance of the blocks. Blocks tested on rubber had the fastest energy dissipation followed by concrete and timber bases, respectively. Analysis of the test results has shown that the energy dissipation in the case of tests on a rubber base is a continuous mechanism whereas in the case of tests on rigid bases, i.e. timber and concrete, energy dissipation is a discrete function. Finally, the rocking characteristics of the blocks were calculated using piecewise equations of motion and numerical analysis. It was possible to predict the correct free rocking amplitude response when a reliable value for the coefficient of restitution was used. Copyright © 2010 John Wiley & Sons, Ltd.
Erector spinae plane block vs. peri‐articular injection for pain control after arthroscopic shoulder surgery: a randomised controlled trial

Interscalene brachial plexus block is the standard regional analgesic technique for shoulder surgery. Given its adverse effects, alternative techniques have been explored. Reports suggest that the erector spinae plane block may potentially provide effective analgesia following shoulder surgery. However, its analgesic efficacy for shoulder surgery compared with placebo or local anaesthetic infiltration has never been established. We conducted a randomised controlled trial to compare the analgesic efficacy of pre‐operative T2 erector spinae plane block with peri‐articular infiltration at the end of surgery. Sixty‐two patients undergoing arthroscopic shoulder repair were randomly assigned to receive active erector spinae plane block with saline peri‐articular injection (n = 31) or active peri‐articular injection with saline erector spinae plane block (n = 31) in a blinded double‐dummy design. Primary outcome was resting pain score in recovery. Secondary outcomes included pain scores with movement; opioid use; patient satisfaction; adverse effects in hospital; and outcomes at 24 h and 1 month. There was no difference in pain scores in recovery, with a median difference (95%CI) of 0.6 (−1.9–3.1), p = 0.65. Median postoperative oral morphine equivalent utilisation was significantly higher in the erector spinae plane group (21 mg vs. 12 mg; p = 0.028). Itching was observed in 10% of patients who received erector spinae plane block and there was no difference in the incidence of significant nausea and vomiting. Patient satisfaction scores, and pain scores and opioid use at 24 h were similar. At 1 month, six (peri‐articular injection) and eight (erector spinae plane block) patients reported persistent pain. Erector spinae plane block was not superior to peri‐articular injection for arthroscopic shoulder surgery.
Balance performance in patients with post-acute COVID-19 compared to patients with an acute exacerbation of chronic obstructive pulmonary disease and healthy subjects

COVID-19 leaves important sequelae in patients, not only in those who had the experience of a critical illness but also in patients with severe form. Understanding the impairments allows us to target rehabilitation to patients’ real needs; balance impairments are an assumed sequela of COVID-19, but no study has specifically evaluated balance performance in these patients. Their performance was compared to that of patients with a pulmonary disease that leads to systemic diseases, such as patients with an acute exacerbation of chronic obstructive pulmonary disease (PwAECOPD), and of healthy subjects. A total of 75 subjects were assessed: 25 patients with COVID-19 (PwCOVID) with a severe form in the acute phase, 25 PwAECOPD and 25 healthy subjects sex- and age-matched. A stabilometric platform was used to evaluate static balance, both with eyes open and closed, while the dynamic balance was assessed with the Mini-BESTest and the Timed Up and Go test. When compared to healthy subjects, results showed that PwCOVID had worse performance in both static (P < 0.005) and dynamic (P < 0.0001) balance, with a large effect size in all measures (>0.8). Moreover, PwCOVID showed similar results to those of PwAECOPD. In conclusion, PwCOVID showed a balance deficit in both dynamic and static conditions. Therefore, as for PwAECOPD, they should require not only respiratory rehabilitation but also balance and mobility physiotherapy to prevent today’s PwCOVID from becoming tomorrow’s fallers.
Understanding safe water‐carrying practices during pregnancy and postpartum: A mixed‐methods study in Nepal

Abstract Daily carrying of heavy loads of domestic water, especially during pregnancy and postpartum, bears a threat to maternal health in low‐income countries. Using an extended health action process approach (HAPA), we examined women's reasons for and psychosocial determinants of safe water‐carrying during pregnancy and postpartum. In a mixed‐methods study, trained local interviewers conducted 1001 quantitative interviews with women of reproductive age (n = 921 analyzed) and 21 qualitative interviews with women of reproductive age, in‐laws, and spouses in rural Nepal. We analyzed the quantitative data with generalized estimating equations to model the HAPA‐based psychosocial determinants of avoiding water‐carrying during pregnancy and postpartum. Subjective perspectives were investigated with thematic analysis. Outcome expectancies (B = 0.24), self‐efficacy (B = 0.20), and injunctive norms (B = 0.23) were significantly associated with the intention to avoid water‐carrying. Self‐efficacy (B = 0.36) and instrumental support (B = 0.05) are related to behavior (all p < 0.05). Women explained water‐carrying during pregnancy by a lack of family support, a shift of health decision‐making power to in‐laws, and low behavioral control. Overall, the necessity of water, family decision‐making structures, and low support make it difficult for women to discontinue water‐carrying. Additionally to infrastructural improvements, behavioral interventions may increase women's self‐efficacy for safe water‐carrying (e.g. reducing weight) and social support.
Maternal inheritance of the koala gut microbiome and its compositional and functional maturation during juvenile development.

The acquisition and maturation of the gastrointestinal microbiome is a crucial aspect of mammalian development, particularly for specialist herbivores such as the koala (Phascolarctos cinereus). Joey koalas are thought to be inoculated with microorganisms by feeding on specialised maternal faeces (pap). We found that compared to faeces, pap has higher microbial density, higher microbial evenness and a higher proportion of rare taxa, which may facilitate the establishment of those taxa in joey koalas. We show that the microbiomes of captive joey koalas were on average more similar to those of their mothers than to other koalas, indicating strong maternal inheritance of the faecal microbiome, which can lead to intergenerational gut dysbiosis when the mother is ill. Directly after pap feeding, the joey koalas' microbiomes were enriched for milk-associated bacteria including Bacteroides fragilis, suggesting a conserved role for this species across mammalian taxa. The joeys' microbiomes then changed slowly over five months to resemble those of adults by one year of age. The relative abundance of fibrolytic bacteria and genes involved in the degradation of plant cell walls also increased in the infants over this time, likely in response to an increased proportion of Eucalyptus leaves in their diets. This article is protected by copyright. All rights reserved.
A Conceptual Framework for Consistency Management in Model-Based Systems Engineering

Developing complex engineering systems requires the consolidation of models from a variety of domains such as economics, mechanics and software engineering. These models are typically created using differing formalisms and by stakeholders that have varying views on the same problem statement. The challenging question is: what is needed to make sure that all of these different models remain consistent during the design process? A review of the related literature reveals that this is still an open challenge and has not yet been investigated at a fundamental level within the context of Model-Based Systems Engineering (MBSE). Therefore, this paper specifically focuses on examining the fundamentals of consistency management. We show that some inconsistencies cannot be detected and come to the conclusion that it is impossible to say whether or not a system is fully consistent. In this paper, we first introduce a mathematical foundation to define consistency in a formal manner. A decision-based approach to design is then studied and applied to the development of a real-world example. The research reveals several distinct types of inconsistencies that can occur during the design and development of a system. We show that these inconsistencies can be further classified into two groups: internal and external consistency. From these insights, the ontology of inconsistencies is constructed. Finally, requirements for possible tool support and methods to identify and manage specific types of consistency issues are proposed.Copyright © 2011 by ASME
bfc, a novel serpent co-factor for the expression of croquemort, regulates efferocytosis in Drosophila melanogaster

Efferocytosis is the process by which phagocytes recognize, engulf, and digest (or clear) apoptotic cells during development. Impaired efferocytosis is associated with developmental defects and autoimmune diseases. In Drosophila melanogaster, recognition of apoptotic cells requires phagocyte surface receptors, including the scavenger receptor CD36-related protein, Croquemort (Crq, encoded by crq). In fact, Crq expression is upregulated in the presence of apoptotic cells, as well as in response to excessive apoptosis. Here, we identified a novel gene bfc (booster for croquemort), which plays a role in efferocytosis, specifically the regulation of the crq expression. We found that Bfc protein interacts with the zinc finger domain of the GATA transcription factor Serpent (Srp), to enhance its direct binding to the crq promoter; thus, they function together in regulating crq expression and efferocytosis. Overall, we show that Bfc serves as a Srp co-factor to upregulate the transcription of the crq encoded receptor, and consequently boosts macrophage efferocytosis in response to excessive apoptosis. Therefore, this study clarifies how phagocytes integrate apoptotic cell signals to mediate efferocytosis.