Miracle-dz/UniFAR-FTUs huggingface dataset:
Effects of Prolonged High-Fat Diet Consumption Starting at Different Ages on Behavioral Parameters and Hippocampal Neuroplasticity in Male Mice.

BACKGROUND The overconsumption of a high-fat diet (HFD) has been repeatedly blamed as being a possible contributor to the global prevalence of emotional problems in modern society. Our group recently demonstrated the deleterious effect of a chronic HFD throughout adulthood on both emotional behavior and neuroplasticity markers in mice. As a heightened preference for palatable HFDs from the time of the juvenile period (when the brain is particularly vulnerable to environmental insults) is universal among populations around the world, a comparison of the consequences of chronic HFDs starting from juveniles or adults will assist in obtaining better knowledge of the impact that chronic HFDs have on mental health, thus potentially leading to the discovery of more effective strategies for reducing the incidence of psychiatric disorders. METHODS In the present study, male C57BL/6J mice with an initial age of 4 weeks (IA-4 W) or 8 weeks (IA-8 W) were separately assigned to two subgroups and fed either a control diet (CD, 10 kJ% from fat) or HFD (60 kJ% from fat) for 9 months followed by an analysis focused on metabolic, emotional behavioral, and neuroplastic profiles. RESULTS The results illustrated that, in addition to abnormal glucolipid metabolism and insulin sensitivity, mice on a chronic HFD exhibited increased levels of anxiety and depression-like behaviors and aberrant hippocampal neuroplasticity. When compared with IA-8 W mice, several changes indicating systemic metabolic disturbance and neurobehavioral disorder after chronic HFD consumption were aggravated in IA-4 W mice, accompanied by exaggerated impairments in hippocampal insulin sensitivity and neurogenesis. CONCLUSIONS These results not only provide in vivo evidence that the juvenile stage is a critical period of vulnerability to detrimental effects of HFD consumption on metabolic and neuronal function but also suggest dampened hippocampal insulin signaling as a potential link between prolonged HFD consumption and negative neurobehavioral outcomes. Considering the substantial burden posed by psychiatric disorders and the high prevalence of HFD among youth, these observations are meaningful for raising awareness of the harmful effects of excessive dietary fat intake and developing strategy for preventing mental disorders.
An information-theoretic analysis of resting-state versus task fMRI

Abstract Resting-state fMRI is an increasingly popular alternative to task-based fMRI. However, a formal quantification of the amount of information provided by resting-state fMRI as opposed to active task conditions about neural responses is lacking. We conducted a systematic comparison of the quality of inferences derived from a resting-state and a task fMRI paradigm by means of Bayesian Data Comparison. In this framework, data quality is formally quantified in information-theoretic terms as the precision and amount of information provided by the data on the parameters of interest. Parameters of effective connectivity, estimated from the cross-spectral densities of resting-state- and task time series by means of dynamic causal modelling (DCM), were subjected to the analysis. Data from 50 individuals undergoing resting-state and a Theory-of-Mind task were compared, both datasets provided by the Human Connectome Project. A threshold of very strong evidence was reached in favour of the Theory-of-Mind task (>10 bits or natural units) regarding information gain, which could be attributed to the active task condition eliciting stronger effective connectivity. Extending these analyses to other tasks and cognitive systems will reveal whether the superior informative value of task-based fMRI observed here is case specific or a more general trend.
Negligible Toxicokinetic Differences of Glyphosate by Different Vehicles in Rats

Glyphosate is a non-selective herbicide. Although glyphosate is not acutely toxic, the intake of glyphosate-based herbicides has caused many accidents. Some studies have suggested that surfactants might be the cause. The purpose of this study was to compare the toxicokinetic (TK) properties of glyphosate according to different vehicles in rats. Glyphosate (1%) was dissolved in distilled water (DW), polyoxyethylene tallow amine (POEA), and Tween 20. After a single oral treatment of glyphosate (50 mg/kg), blood was collected at time intervals, and glyphosate concentrations in the target organ (liver and kidney) were determined 24 h after final blood collection. All samples were analyzed using LC-MS/MS. The TK parameters of glyphosate were similar in the DW and Tween 20 groups. However, there were significant differences in Tmax and volume of distribution (Vd) between the DW and POEA group (p < 0.05). Glyphosate was absorbed about 10 times faster in POEA group rather than DW, and exhibited a higher distribution. However, other important TK parameters of T1/2, AUC, and Cmax were not statistically different among the different vehicle groups. Although glyphosate concentration in the liver was significantly higher in the POEA group than in the DW group, there was no significant difference in the kidney. These results indicate that the toxicokinetics of glyphosate are not significantly affected by POEA. It can be concluded that POEA toxicity itself can be attributed to the acute toxicity of glyphosate-containing products.
Relationship of Motor Impairment with Cognitive and Emotional Alterations in Patients with Multiple Sclerosis

Introduction. Multiple sclerosis (MS) is a neurodegenerative disease that, despite mainly affecting women, is more severe in men and causes motor, cognitive and emotional alterations. The objective of this study was to determine the possible relationship between motor, cognitive and emotional alterations. Materials and Methods. This is a descriptive, observational and cross-sectional study, with 67 patients with MS (20 men and 47 women), who were given the following questionnaires: Expanded Disability Status Scale (EDSS), Two-Minute Walk Test (2MWT), Berg Balance Scale, Beck’s Depression Inventory (BDI-II), State-Trait Anxiety Inventory (STAI) and Prefrontal Symptoms Inventory (PSI) to analyze their cognitive level, body mass index (BMI) and percentage of muscle mass. In addition, regression analysis was conducted to study the relationship among variables. Results. No significant differences were found between men and women in any of the variables. Regarding the relationship between parameters, the regression analysis was statistically significant, showing an effect of age on the walking and balance performance (β ≅ −0.4, p < 0.05); in addition, there was a relationship between 2MWT and STAI A/S, indicating that both older age and a high anxiety state could impact walking performance. On the other hand, prefrontal symptoms showed moderate relationships with both anxiety and depression (β ≅ 0.6, p < 0.05); thus, high levels of anxiety and depression could increase prefrontal alterations. Conclusions. There is a relationship between motor and emotional variables. Specifically, state anxiety is related to walking resistance. No relationship was found between depression and cognitive alteration and balance or walking ability. Only age has an effect in these relationships.
Coaching psychology research: Building the evidence, developing awareness

In December 2011 Dr Rob Briner was giving an after dinner speech at the Special Group in Coaching Psychology (SGCP) conference dinner, in which he highlighted the lack of empirically sound research for the discipline of coaching psychology. He asked the audience to give examples of coaching psychology research. Radio silence. Followed by an air of disgruntlement. Once I personally got over the feeling of being caught out for not doing my homework, I wanted to offer some suggestions. Not regarding specific published research, but regarding my own experiences of trying to conduct solid coaching psychology research. The moment had gone, but I did havethe opportunity to discuss this with colleagues at the conference the next day, and was subsequently asked to share my thoughts more widely, hence this article. Thefollowing discussion outlines some practical explanations for the proposed dearth of solid empirical research. It also highlights that there is some good research out there already, and looks at how we can make this more accessible, as well as encouraging more evidence published by practitioners.
Att göra livet (över)levbart: Transpersoners ontiska, relationella och reflekterande arbete för att skapa minoritetsro och hantera utsatthet i vardagen

Transgender people report significantly poorer mental health than cisgender people. In psychological research, these health disparities are explained by theories of minority stress and microaggressions, while other disciplines use theories on normativity, livability, affective work, world making and utopias. Such theories are seldom picked up by psychologists even though they could serve to help psychological research and practice improve mental health in transgender people.The aim of this interview study was twofold. Empirically, it was to explore how 29 transgender people in Sweden (aged 17-63 years), experience and cope with vulnerability to make life survivable/livable. Analytically, psychological theories of minority stress, microaggressions and coping were put in conversation with theories of livability and emotional labor. Queer phenomenology was used to orient our analysis of the empirical material, as well as orient us theoretically, to find new ways of understanding transgender people’s vulnerability psychologically.While participants’ negative experiences are interpreted as covered by theories on minority stress and microaggressions, these theories do not explain all nuances of the exposure. In addition, theories on coping do not fully capture the constantly ongoing work participants need to do to manage everyday situations. The analysis resulted in three themes. One theme describes the ontic work that participants do in response to existential challenges of not being recognized as a subject. Another theme visualizes the relational work that participants do to deal with subtle exposure in their everyday life, trying to relate to oneself and others simultaneously. The final theme shows that participants utilize reactive and agentic reflexivity to try to achieve minority peace and a livable life. We hope that this dialogue between psychology and gender studies can continue in a Swedish context to better serve transgender people’s livability.
Self-Control and Curiosity: Has Curiosity Been an Overlooked Concept in the Crime/Deviance Decision-Making Process?

ABSTRACT We conducted an empirical test of Gottfredson and Hirschi’s, 1990 A General Theory of Crime in this exploratory study to introduce the concept of curiosity to criminological theory. Specifically, we tested whether self-control was significantly associated with curiosity and whether curiosity significantly predicted a crime/deviance index beyond the effects of self-control. An original eight item curiosity scale was created that measured both an attitudinal curiosity dimension and a behavioral curiosity component and compared the ability of this new measure with the capability of the most commonly used self-control scale in predicting a crime/deviance index. Data was derived from a convenience sample of college students. As theoretically predicted, self-control was significantly correlated with curiosity, and the curiosity scale significantly predicted the crime/deviance index, beyond the effects of the self-control scale. More conservative tests demonstrated that curiosity also significantly predicted involvement in more specific illegal/deviance measures, including those involving somewhat serious delinquent/criminal conduct. The findings led us to conclude that curiosity may be another additional cause of crime/deviance beyond the effects of self-control, curiosity explains more than just involvement in exploratory types of illegal/deviant behavior, and that curiosity has been an overlooked concept in the crime/deviance decision-making process.
ECG Identification Based on the Gramian Angular Field and Tested with Individuals in Resting and Activity States

In the last decade, biosignals have attracted the attention of many researchers when designing novel biometrics systems. Many of these works use cardiac signals and their representation as electrocardiograms (ECGs). Nowadays, these solutions are even more realistic since we can acquire reliable ECG records by using wearable devices. This paper moves in that direction and proposes a novel approach for an ECG identification system. For that, we transform the ECG recordings into Gramian Angular Field (GAF) images, a time series encoding technique well-known in other domains but not very common with biosignals. Specifically, the time series is transformed using polar coordinates, and then, the cosine sum of the angles is computed for each pair of points. We present a proof-of-concept identification system built on a tuned VGG19 convolutional neural network using this approach. We confirm our proposal’s feasibility through experimentation using two well-known public datasets: MIT-BIH Normal Sinus Rhythm Database (subjects at a resting state) and ECG-GUDB (individuals under four specific activities). In both scenarios, the identification system reaches an accuracy of 91%, and the False Acceptance Rate (FAR) is eight times higher than the False Rejection Rate (FRR).
Anti-Inflammatory Effects of the 35kDa Hyaluronic Acid Fragment (B-HA/HA35)

Background Hyaluronic acid (HA) and HA fragments interact with a variety of human body receptors and are involved in the regulation of various physiological functions and leukocyte trafficking in the body. Accordingly, the development of an injectable HA fragment with good tissue permeability, the identification of its indications, and molecular mechanisms are of great significance for its clinical application. The previous studies showed that the clinical effects of injectable 35kDa B-HA result from B-HA binding to multiple receptors in different cells, tissues, and organs. This study lays the foundation for further studies on the comprehensive clinical effects of injectable B-HA. Methods We elaborated on the production process, bioactivity assay, efficacy analyses, and safety evaluation of an injectable novel HA fragment with an average molecular weight of 35 kDa (35 kDa B-HA), produced by recombinant human hyaluronidase PH20 digestion. Results The results showed that 35 kDa B-HA induced human erythrocyte aggregation (rouleaux formation) and accelerated erythrocyte sedimentation rates through the CD44 receptor. B-HA application and injection treatment significantly promoted the removal of mononuclear cells from the site of inflammation and into the lymphatic circulation. At a low concentration, 35 kDa B-HA inhibited production of reactive oxygen species and tumor necrosis factor by neutrophils; at a higher concentration, 35 kDa B-HA promoted the migration of monocytes. Furthermore, 35 kDa B-HA significantly inhibited the migration of neutrophils with or without lipopolysaccharide treatment, suggesting that in local tissues, higher concentrations of 35 kDa B-HA have antiinflammatory effects. After 99mTc radiolabeled 35 kDa B-HA was intravenously injected into mice, it quickly entered into the spleen, liver, lungs, kidneys and other organs through the blood circulation. Conclusion This study demonstrated that the HA fragment B-HA has good tissue permeability and antiinflammatory effects, laying a theoretical foundation for further clinical studies.
Investigating experiences of the Family Connections Programme for supporters of individuals with a diagnosis of Borderline Personality Disorder

We interviewed relatives and carers following their participation in a novel Family Connection (FC) programme, designed for supporters of individuals with a diagnosis of Borderline Personality Disorder. A mixed methods approach was utilised to quantitatively measure depression, ‘burden’, grief and mastery, pre and post-group, whilst qualitative analysis identified four themes: ‘Positive Experience’, ‘Not Alone’, ‘Management of Emotions and Behaviours’ and ‘Recommendations’. Quantitative measures suggest that FC could be helpful in alleviating depression and ‘burden’ and increasing mastery, although it could increase the experience of grief. Implications for future research and the possible impact of FC amongst this group are discussed.
Some Restrictions on the Maps in Minimal Resolutions

Abstract We show that there are certain restrictions on the entries of the maps in the minimal free resolutions of finitely generated modules of infinite projective dimension over Noetherian local rings. These restrictions provide a way to slightly improve Herzog's characterization of modules of finite projective and injective dimensions in characteristic p > 0. We also discuss other homological situations related to these restrictions, including previously known results on the existence of free summands in syzygy modules.
Diabatic heating in an axisymmetric cut‐off cyclone and related stratosphere‐troposphere exchange

A mechanistic axisymmetric Eliassen balanced vortex model is presented for the investigation of the role of diabatic heating in the dynamic evolution of a cut-off cyclone and the related stratosphere-troposphere exchange. As an initial state, a balanced upper-level vortex is chosen representing an idealized cut-off cyclone. After specifying a diabatic heating field, which is supposed to simulate latent heat release in deep convection, one can diagnose the induced cross-vortex circulation and calculate the ensuing vortex evolution. Tropospheric heating with a maximum of some 10 K d−1 underneath the lowered tropopause leads to the decay of the upper-level vortex within a few days. During the decay there is a sizeable, diabatically induced mass flux across the PV-defined tropopause: air in the vortex centre which initially was part of the lower stratosphere gradually turns into tropospheric air. This stratosphere-troposphere exchange depends sensitively on the heating profile around the tropopause level and, hence, on the maximum height reached by the convection. The inclusion of diabatic cooling to account for the effect of radiation at cloud tops leaves the vortex evolution almost unchanged but increases the rate of stratosphere-troposphere exchange dramatically. Cross-isentropic mixing alone may result in strengthening rather than in weakening the vortex thus re-emphasizing the role of diabatic heating during decay.
On the orientation of hydromagnetic waves in the magnetosphere

We review evidence gathered from theortical considerations and from measurements on the ground and in space for a 90/sup 0/ rotation of the major axis of the polarization ellipse of geomagnetic pulsation signals between the geomagnetic equator and the ground. The evidence at present supports the existence of the rotation phenomenon, although more observational work is needed. The rotation arises from the nonconducting air on the ground surface and the highly conducting plasma in space.
Boundary-layer flow at a saddle point of attachment

This paper is a study of the flow of a viscous incompressible fluid in the immediate neighbourhood of a saddle point of attachment, near which the external flow is irrotational with components {ax, by, −(a + b)z}, where a > 0 > b. It is shown that the flow is of a boundary-layer character, and that part of the boundary-layer flow is reversed when b/a < − 0·4294. On the assumption that such flows are physically plausible, the problem may be solved for all values of b/a [ges ] −1. Even in the limiting case b/a = −1, an effect of the boundary layer is everywhere to draw fluid towards the wall, so that vorticity is still convected towards the wall. Numerical solutions have been computed, and some of the results are presented in the tables and diagrams.
Estimation and Mapping of Hurricane Turbulent Energy Using Airborne Doppler Measurements

Abstract Hurricane turbulent kinetic energy (TKE) was computed using airborne Doppler measurements from the NOAA WP-3D tail radars, and TKE data were retrieved for a variety of storms at different stages of their life cycle. The geometry of the radar analysis coupled with the relatively small beam resolution at ranges <8 km allowed for the estimation of subkilometer turbulent processes. Two-dimensional profiles of TKE were constructed and revealed that the strongest turbulence was generally located in convective regions, such as the eyewall, with magnitudes often exceeding 15 m2 s−2 and in the boundary layer with values of 5–10 m2 s−2 in the lowest kilometer. A correlation analysis showed that the strong turbulence was generally associated with strong horizontal shear of vertical and radial wind components in the eyewall and strong vertical shear of horizontal wind in the boundary layer. Mean vertical profiles of TKE decrease sharply above the hurricane boundary layer and level off at low magnitude for al.
Differential Regulation of Glucosylceramide Synthesis and Efflux by Golgi and Plasma Membrane Bound ABCC10

Glucosylceramide (GlcCer) synthesis by the enzyme glucosylceramide synthase (GCS) occurs on the cytosolic leaflet of the Golgi and is the first important step for the synthesis of complex glycosphingolipids (GSLs) that takes place inside the lumen. Apart from serving as a precursor for glycosylation, newly synthesized GlcCer is also transported to the plasma membrane and secreted onto HDL in the circulation. The mechanism by which GlcCer is transported to HDL remains unclear. Recently, we showed that ATP-binding cassette transporter protein C10 (ABCC10) plays an important role in the synthesis and efflux of GlcCer in Huh-7 cells. In this study, we found that treatment of Huh-7 cells with an ABCC10 inhibitor, sorafenib, decreased the synthesis and efflux of GlcCer. However, treatment of cells with cepharanthine reduced only the efflux, but not synthesis, of GlcCer. These results indicate that ABCC10 may regulate the synthesis and efflux of GlcCer differentially in liver cells.
The Daily Behavior of Pressure and Its Influence on the Wind Regime in East Antarctica during the Winters of 1993 and 1994

Abstract The analysis of surface pressure data obtained in 1993–94 at the Dumont d'Urville meteorological station and at Automatic Weather Stations Dome C, D-47, and D-80 (East Antarctica) shows the existence of a daily variation. Power spectra are characterized by the presence of a pronounced 1/2-day peak; a 1-day peak is only slightly evident. However, the magnitude of the spectral density at 1 day is about 4–6 times higher than that of 1/2 day. This behavior is different from that observed at lower latitudes, at which two pronounced peaks at 1 and 1/2 day, of similar magnitude, are observed. The yearly averaged daily pressure time series show two maxima, one at 0900 LT and the other at 2100 LT. The magnitude of this variation increases toward the coast, that is, varying from 0.25 hPa at Dome C to 0.4–0.6 hPa at Dumont d'Urville. The difference of the daily pressure behavior at individual sites produces a daily variation in the quasi-meridional pressure gradient between different pairs of stations. This.