Miracle-dz/UniFAR-FTUs huggingface dataset:
Leukocyte as an Independent Predictor of Lower-Extremity Deep Venous Thrombosis in Elderly Patients With Primary Intracerebral Hemorrhage

Objective Due to the interaction of leukocytes with platelets and coagulation factors, they may in turn play a role in hemostasis or the formation of thrombi. This study aimed to investigate the association of leukocytosis on admission with an increased risk of acute lower-extremity deep venous thrombosis (LEDVT) in elderly patients with primary intracerebral hemorrhage (ICH). Methods This was a single-center, retrospective observational study of consecutive patients observed with spontaneous ICH aged 60 years or above at Lanzhou University Second Hospital from January 2017 to September 2021. Clinical data and demographic information were collected and analyzed. Univariate and multivariate analyses were conducted to identify independent risk factors of acute LEDVT. One-to-one matching was implemented to balance important patient characteristics by the groups' propensity score matching (PSM) analysis. Results A total of 371 elderly patients with primary ICH fulfilled requirements for inclusion and exclusion, of whom 33 (8.89%) experienced LEDVT. Leukocyte counts were statistically higher in the LEDVT group compared to the non-LEDVT group [12.89 (8.80–14.61) × 109 cells/L vs. 8.31 (6.60–10.75) × 109 cells /L, p < 0.001]. Multivariate logistic regression models adjusted for several potential confounding factors were performed, and leukocytes were consistently a significant independent predictor of LEDVT. The optimal cut-off value of leukocyte counts calculated from the receiver operating characteristic (ROC) curve to predict LEDVT was 10.22 × 109 cells /L (area under the curve:0.714, 95%CI 0.665–0.759; the sensitivity was 72.73%; the specificity was 71.01%) in elderly patients with primary ICH. After one-to-one PSM, compared to the matched non-LEDVT group, the matched LEDVT group had significantly higher leukocyte counts [11.98 (8.40–13.94) × 109 cells/L vs. 6.12 (4.68–12.00) × 109 cells/L, p = 0.003]. After PSM, the ROC curve was plotted for leukocytes as a predictor of LEDVT, with an AUC of 0.722 (95%CI 0.593–0.828, p = 0.001; the sensitivity was 87.10%, and the specificity was 61.29%). Elevated leukocytes remained independently significant as predictors of LEDVT in elderly patients with primary ICH. Conclusion Leukocyte at admission is an independent risk factor of LEDVT in elderly patients with primary ICH.
Using Open Source Data to Measure Street Walkability and Bikeability in China: A Case of Four Cities

Whether people would choose to walk or ride a bike for their daily travel is affected by how desirable the environment is for walking and biking. To better inform urban planning and design practices, studies on measuring walkability and bikeability have emerged in western countries over the last decade. However, such efforts are still rare in developing countries, partially due to the scarcity of urban data. Utilizing open source data, this paper puts forward a methodology to comprehensively and objectively measure street walkability and bikeability in China. The methodology was applied to four Chinese cities: Tianjin, Chongqing, Kunming, and Shijiazhuang. Analyses showed the following results: (1) city centers tend to have higher walkability than periphery areas; (2) a preliminary bikeable street network exists in most cities (except mountainous cities), but the prevalence of bike lanes on streets is much lower than that of sidewalks; (3) the problem of illegal parking on both sidewalks and bike lanes is severe, especially in city centers; (4) biking safety and comfort is compromised due to a lack of physically separated bike lanes; and (5) the street wall continuity varies from place to place whereas the street network in traditional city centers is much denser than newly developed car-oriented areas. The end of the paper provides corresponding policy implications.
Influence of employee-manager relationship on employee performance and productivity

Organizational performance can be seen as dependent on employee job performance and productivity. One of the factors that influence employee job performance and productivity is the working relationship between employees and their managers. This paper examines the influence of the relationship between employees and their managers on enhancing employee performance and productivity. The study was conducted in a financial organization based in Durban (South Africa). A quantitative approach was utilized with a census method targeting a total population of 40 administrative employees. A questionnaire was constructed based on the research aims and was administered to all 40 respondents. As a result, the response rate was 65%. Key findings indicated that the relationship between managers and employees did affect employee performance and productivity. A positive relationship with a manager is closely linked to increased motivation and performance, while a negative relationship is linked with poor performance. An overall negative impact and high level of dissatisfaction amongst employees were found due to the current bureaucratic management style that managers adopt in their organization. Thus, it makes employees less productive and decreases their work performance. Furthermore, it was found that employees’ perception of their relationship with managers plays a significant role in predicting job performance. Recommendations for a better working relationship to promote employee performance and productivity include manager-employee training, team building activities, skills development programs for managers, employee rewards and recognition, increased communication platforms, and more consideration for employee well-being.
Large-Scale Meteorological Drivers of the Extreme Precipitation Event and Devastating Floods of Early-February 2021 in Semarang, Central Java, Indonesia

Unusually long duration and heavy rainfall from 5 to 6 February 2021 caused widespread and devastating floods in Semarang, Central Java, Indonesia. The heavy rainfall was produced by two mesoscale convective systems (MCSs). The first MCS developed at 13Z on 5 February 2021 over the southern coast of Sumatra and propagated towards Semarang. The second MCS developed over the north coast of Semarang at 18Z on 5 February 2021 and later led to the first peak of precipitation at 21Z on 5 February 2021. These two MCSs eventually merged into a single MCS, producing the second peak of precipitation at 00Z on 6 February 2021. Analysis of the moisture transport indicates that the strong and persistent north-westerly wind near the surface induced by CENS prior to and during the event created an intensive meridional (southward) tropospheric moisture transport from the South China Sea towards Semarang. In addition, the westerly flow induced by low-frequency variability associated with La Nina and the tropical depression over the North of Australia produced an intensive zonal (eastward) tropospheric moisture transport from the Indian Ocean towards Semarang. The combined effects of the zonal and meridional moisture transport provided favorable conditions for the development of MCSs, and hence extreme rainfall over Semarang. These results provide useful precursors for extreme weather-driven hazard prediction in Semarang and the surrounding regions in the future.
Influence on storage condition and time on properties of carbonated beverages from utilization of polyethylene terephthalate (PET) bottles: chemometric and health risk assessment

The effect of storage condition (room temperature and sunlight exposure) of eight carbonated beverages sold in Nigeria were assessed over a period of 15 weeks of storage time. Properties such as antimony (Sb) leaching, pH, acidity, specific gravity (S.G.) and total soluble solid content (TSSC) were analyzed using appropriate instrument and methodology at three weeks interval respectively. The concentration of Sb determined ranged from 0.001–0.011 mg/L and 0.001–0.0015 mg/L for room temperature and sunlight exposure. pH was between 2.82–4.81 and 2.82–4.82. TSSC were 0–14 O brix and 0–14.96 O brix. Acidity were 0.025–0.19 and 0.025–0.34. Specific gravity was 0.9921–1.052 and 0.9921–1.0577. The result shows that pH decreased with time as Sb, TSSC, acidity and S.G. increased with time thereby influencing significance (p<0.05). Difference in Sb amounts shows that sunlight exposure had more impacts compared to room temperature as storage time increased. TSSC values increased steadily leading to hydrolysis of sugar and other chemical ingredients, thus affecting the specific gravity. Acidity impacted by increased reactivity from carbon dioxide present, which reduces pH of the drink. Chemometric assessment such as contamination factor and pollution load index indicate low concentration and no pollution associated. Factor analysis conducted showed that all parameters and storage time were positively interrelated except for pH due to side reaction. Cumulative variance showed high variance (>50). Health risk assessment conducted for adults and children showed that Tolerable Dose Index and Hazard Index were below one, thus indicates no adverse health impact as the values were relatively higher in children compared to adults. Prolong consumption of carbonated drinks stored longer than expected can cause fatigue and headaches on a short-term basis, and weight loss and diabetes on a long run especially in children. Regular parental monitoring is advised to mitigate health impact for children.
Outcomes of patients with Wilms' tumour stage III due to positive resection margins only: An analysis of patients treated on the SIOP‐WT‐2001 protocol in the UK‐CCLG and GPOH studies

Stage III Wilms' tumour (WT) represents a heterogeneous group which includes different criteria, but all stage III patients are treated according to the same study regiment. The aim of the study was to retrospectively analyse outcomes in patients with stage III due to positive resection margins (RM) only, sub‐grouped in RM with viable (RM‐v) and nonviable (RM‐nv) tumour. Patients were treated pre‐ and postoperatively according to the SIOP‐WT‐2001 protocol in the UK‐CCLG and GPOH WT trials and studies (2001‐2020). There were 197 patients, including 134 with localised, abdominal stage III and 63 with overall stage IV, but abdominal stage III. Stage III due to RM‐v had 126 patients, and due to RM‐nv 71 patients. The overall 5‐year local‐relapse‐free survival (RFS), event‐free (EFS) and overall survival (OS) estimates for all patients with abdominal stage III RM were 95.7% (±SE1.5%), 85.1 (±SE2.6%) and 90.3% (±SE2.2%), respectively. Patients with stage III RM‐nv had significantly better RFS and EFS than patients with RM‐v (P = .027 and P = .003, respectively). A multivariate analysis showed that RM‐v remained a significant factor for EFS when adjusted for age, presence of metastasis at diagnosis, histological risk group and overall stage in Cox regression analysis (P = .006). Patients with stage III due to RM‐nv only exhibited no local recurrence and have a significantly better RFS and EFS than patients with RM‐v. The results suggest that exclusion of RM‐nv as a stage III criterion in the UMBRELLA staging system and consequent treatment reduction is warranted.
An Improved Estimation for Heterogeneous Datasets with Lower Detection Limits regarding Environmental Health

Analysis of environmental data with lower detection limits (LDL) using mixture models has recently gained importance. However, only a particular type of mixture models under classical estimation methods have been used in the literature. We have proposed the Bayesian analysis for the said data using mixture models. In addition, an optimal mixture distribution to model such data has been explored. The sensitivity of the proposed estimators with respect to LDL, model parameters, hyperparameters, mixing weights, loss functions, sample size, and Bayesian estimation methods has also been proposed. The optimal number of components for the mixture has also been explored. As a practical example, we analyzed two environmental datasets involving LDL. We also compared the proposed estimators with existing estimators, based on different goodness of fit criteria. The results under the proposed estimators were more convincing as compared to those using existing estimators.
Urban Heritage and its Socioeconomic Impacts in Seoul, South Korea: An Empirical Study Using Residential Environmental Satisfaction and Housing Price as Indicators

Background and objective: Recent research has highlighted the need for urban heritage conservation due to rapid urbanisation, especially in Asian cities; however, few studies have investigated the socioeconomic impacts of heritage assets in urban contexts. This study examined urban heritage sites in Seoul Metropolitan City from the perspective of residents' environmental satisfaction and housing prices.Methods: A spatial regression model was developed to examine the associations between urban heritage sites and their corresponding protected areas as the independent variables (nationally assigned cultural heritage, city-assigned cultural heritage, nationally registered cultural heritage, nationally assigned cultural heritage protected area, and city-assigned cultural heritage protected area) and residential environmental satisfaction and housing prices as the dependent variables. The model investigated how urban heritage sites influence housing prices through the mediating effect of residential environmental satisfaction.Results: The results confirmed the impact of urban heritage sites on housing prices and the mediating effect of residential environmental satisfaction. Moreover, depending on their urban heritage classifications, noticeable differences were evident in the impact of urban heritage sites.Conclusion: These findings provide an intellectual foundation for public policies, offering insights into how they might achieve an optimum balance between private and public interests in matters of heritage conservation.
PENGARUH MODEL PEMBELAJARAN PROJECT BASED LEARNING TERHADAP KREATIVITAS SISWA SEKOLAH DASAR

This research is motivated by the low creativity of science students in elementary schools. Education in the era of the industrial revolution 4.0 is expected for students to have high creative abilities to be able to solve problems in real life every day. To realize the achievement of these expectations, an innovative and creative learning model is needed, namely Project based Learning. This study aims to determine the effect of the project-based learning model on the creativity of elementary school students. This study uses a quantitative approach with the type of pre-experimental research using a one group pretest-posttest design. The research subjects were students of SD Negeri Kamal 1 Bangkalan, totaling 32 students. Data collection techniques using a questionnaire instrument. Judging from the average creativity of students before being given project-based learning was 24.59 and after being given project-based learning the average value was 34.81, meaning there was an increase of 11.22 so there was a difference before and after the application of the project-based learning model. While the data hypothesis test using the paired sample t test technique obtained a sig (2-tailed) value of 0.000 which is smaller than 0.05, it can be concluded that there is an effect of project-based learning on students' creativity. Project based learning is effective in increasing creativity skills in science lessons for fourth graders at the Kamal 1 Public Elementary School Bangkalan. ABSTRAKPenelitian ini dilatar belakangi rendahnya kreativitas siswa IPA disekolah dasar. Pendidikan di era revolusi industri 4.0 diharapkan peserta didik memiliki kemamampuan kreatifitas yang tinggi agar mampu memecahkan masalah-masalah dalam kehidupan nyata se hari-hari. Untuk mewujudkan ketercapaian harapan tersebut maka diperlukan model pembelajaran yang inovatif dan kreatif yaitu pembelajaran Project based Learning. Penelitian ini bertujuan untuk mengetahui pengaruh model pembelajaran project based learning terhadap kreativitas siswa sekolah dasar. Penelitian ini menggunakan pendekatan kuantitatif dengan jenis penelitian pre eksperimen dengan menggunakan one group pretest-posttest design. Subyek penelitian siswa SD Negeri Kamal 1 Bangkalan yang berjumlah 32 siswa. Tehnik pengumpulan data menggunakan instrumen angket. Dilihat dari rata-rata kreativitas siswa sebelum diberi project based learning adalah 24,59 dan sesudah diberi project based learning rata nilainya 34.81 berarti ada kenaikan sebesar 11,22 jadi ada perbedaan sebelum dan sesudah penerapan model pembelajaran project based learning. Sedangkan Uji hipotesis data dengan menggunkan teknik paired sampel t test diperoleh nilai sig (2-tailed) 0,000 lebih kecil dari 0,05 maka dapat disimpulkan bahwa ada pengaruh model pembelajaran project based learning terhadap kreativitas siswa. Pembelajaran project based learning efektif untuk meningkatkan kemampuan kreativitas dalam pelajaran IPA siswa kelas IV sekolah dasar negeri kamal 1 Bangkalan.
Distributional Benefits of Rooftop Solar Capacity

This paper explores the distribution of environmental benefits created by rooftop solar capacity in the United States. We find that benefits are increasing with income, indicating regressivity, but that households of color receive greater per capita benefits on average. Moreover, we document minimal efficiency-equity trade-off: capacity allocations that maximize total environmental benefits are nearly identical to allocations that maximize benefits received by disadvantaged groups. Thus, existing solar capacity forgoes up to $2 billion annually in environmental benefits as well as substantial improvements in distributional outcomes, further suggesting that the suboptimality of existing solar policy cannot be rationalized on equity grounds.
Techno-Economic Assessment of Green Ammonia Production with Different Wind and Solar Potentials

This paper focuses on developing a fast-solving open-source model for dynamic power-to-X plant techno-economic analysis and analysing the method bias that occurs when using other state-of-the-art power-to-X cost calculation methods. The model is a least-cost optimisation of investments and operation-costs, taking as input techno-economic data, varying power profiles and hourly grid prices. The fuel analysed is ammonia synthesised from electrolytic hydrogen produced with electricity from photovoltaics, wind turbines or the grid. Various weather profiles and electrolyser technologies are compared. The calculated costs are compared with those derived using methods and assumptions prevailing in most literature. Optimisation results show that a semi-islanded set-up is the cheapest option and can reduce the costs up to 23% compared to off-grid systems but leads to e-fuels GHG emissions similar to fossil fuels with today’s electricity blend. For off-grid systems, estimating costs using solar or wind levelized cost of electricity and capacity factors to derive operating hours leads to costs overestimation up to 30%. The cheapest off-grid configuration reaches production costs of 842 e /t 𝑁𝐻 3 . For comparison, the "grey" ammonia price was 250 e /t 𝑁𝐻 3 in January 2021 and 1500 e /t 𝑁𝐻 3 in April 2022 (Western Europe). The optimal power mix is found to always include photovoltaic with 1-axis tracking and sometimes different types of onshore wind turbines at the same site. For systems fully grid connected, approximating a highly fluctuating electricity price by a yearly average and assuming a constant operation leads to a small cost ( < 4%) overestimation compared to the more advanced optimisation method applied here .
Retinal Delivery of the Protein Kinase C-β Inhibitor Ruboxistaurin Using Non-Invasive Nanoparticles of Polyamidoamine Dendrimers

Ruboxistaurin (RBX) is an anti-vascular endothelial growth factor (anti-VEGF) agent that is used in the treatment of diabetic retinopathy and is mainly given intravitreally. To provide a safe and effective method for RBX administration, this study was designed to develop RBX nanoparticles using polyamidoamine (PAMAM) dendrimer generation 5 for the treatment of diabetic retinopathy. Drug loading efficiency, and in vitro release of proposed complexes of RBX: PAMAM dendrimers were determined and the complexation ratio that showed the highest possible loading efficiency was selected. The drug loading efficiency (%) of 1:1, 2.5:1, and 5:1 complexes was 89.2%, 96.4%, and 97.6%, respectively. Loading capacities of 1:1, 2.5:1, and 5:1 complexes were 1.6%, 4.0%, and 7.2% respectively. In comparison, the 5:1 complex showed the best results in the aforementioned measurements. The in vitro release studies showed that in 8 h, the RBX release from 1:1, 2.5:1, and 5:1 complexes was 37.5%, 35.9%, and 77.0%, respectively. In particular, 5:1 complex showed the highest drug release. In addition, particle size measurements showed that the diameter of empty PAMAM dendrimers was 214.9 ± 8.5 nm, whereas the diameters of loaded PAMAM dendrimers in 1:1, 2.5:1, 5:1 complexes were found to be 461.0 ± 6.4, 482.4 ± 12.5, and 420.0 ± 7.1 nm, respectively. Polydispersity index (PDI) showed that there were no significant changes in the PDI between the free and loaded PAMAM dendrimers. The zeta potential measurements showed that the free and loaded nanoparticles possessed neutral charges due to the presence of anionic and cationic terminal structures. Furthermore, the safety of this formulation was apparent on the viability of the MIO-M1 cell lines. This nanoformulation will improve the therapeutic outcomes of anti-VEGF therapy and the bioavailability of RBX to prevent vision loss in patients with diabetic retinopathy.
Blood ACE Phenotyping for Personalized Medicine: Revelation of Patients with Conformationally Altered ACE

Background: The angiotensin-converting enzyme (ACE) metabolizes a number of important peptides participating in blood pressure regulation and vascular remodeling. Elevated blood ACE is a marker for granulomatous diseases and elevated ACE expression in tissues is associated with increased risk of cardiovascular diseases. Objective and Methodology: We applied a novel approach —ACE phenotyping—to find a reason for conformationally impaired ACE in the blood of one particular donor. Similar conformationally altered ACEs were detected previously in 2–4% of the healthy population and in up to 20% of patients with uremia, and were characterized by significant increase in the rate of angiotensin I hydrolysis. Principal findings: This donor has (1) significantly increased level of endogenous ACE inhibitor in plasma with MW less than 1000; (2) increased activity toward angiotensin I; (3) M71V mutation in ABCG2 (membrane transporter for more than 200 compounds, including bilirubin). We hypothesize that this patient may also have the decreased level of free bilirubin in plasma, which normally binds to the N domain of ACE. Analysis of the local conformation of ACE in plasma of patients with Gilbert and Crigler-Najjar syndromes allowed us to speculate that binding of mAbs 1G12 and 6A12 to plasma ACE could be a natural sensor for estimation of free bilirubin level in plasma. Totally, 235 human plasma/sera samples were screened for conformational changes in soluble ACE. Conclusions/Significance: ACE phenotyping of plasma samples allows us to identify individuals with conformationally altered ACE. This type of screening has clinical significance because this conformationally altered ACE could not only result in the enhancement of the level of angiotensin II but could also serve as an indicator of free bilirubin levels.