Miracle-dz/UniFAR-FTUs huggingface dataset:
High-fat diet intake modulates maternal intestinal adaptations to pregnancy, and results in placental hypoxia and impaired fetal gut development

Shifts in maternal intestinal microbiota have been implicated in metabolic adaptations to pregnancy. In this study we investigated how high-fat diet intake impacts the maternal gut microbiota, intestinal inflammation and gut barrier integrity, placental inflammation, and fetal intestinal development at E18.5. High-fat diet (HFD) was associated with decreased relative abundancesof SCFA producing genera during pregnancy. These diet-induced shifts paralleled decreased maternal intestinal mRNA levels of SCFA receptor Gpr41, modestly decreased cecal butyrate, and altered mRNA levels of inflammatory cytokines and immune cell markers in the maternal intestine. Maternal HFD resulted inimpaired gut barrier integrity, with corresponding increases in circulating maternal levels of LPS and TNF.Placentafromhigh-fat fed damsdemonstrated blood vessel immatu-rityand hypoxia, decreased freecarnitine, acylcarnitine derivatives, TMAO, as well as altered mRNA levels of inflammation, autophagy and ER stress markers. HFD exposed fetuses had increased activation of NF-κB and inhibition of the unfolded protein response in the developing intestine. Together, these data suggest that high-fat diet intake prior to and during pregnancy shifts the composition of the maternal gut microbiota and impairs gut barrier integrity, resulting in increased maternal circulating LPS, which may ultimate contribute to changes in placental vasculariza-tion and fetal gut development. Funding information Farncombe Family Digestive Health Research Institute (KMK); Canadian Institute of Health Research (CJB); Canada Research Chairs Program (MGS, DMS); Natural Sciences and Engineering Research Council of Canada, Genome Canada (PBM).
De‐motivators for the adoption of agile methodologies for large‐scale software development teams: An SLR from management perspective

Most of the software development projects have traditionally been faced with severe problems in terms of quality, cost, and time. Researchers and practitioners have focused on agile software development methods (ASDMs) as an alternative to overcome these problems. Agile methods employ iterative development cycles, interspersed by user feedback. Agile methods were basically developed for small development teams. Scaling agile methods is a big issue from different perspectives. De‐motivators play a key role in project management as it allows early identification and prompt management of threats that may arise during project execution. The objective of this paper is to identify the de‐motivators while scaling agile at large, from management perspectives. We have adapted SLR and applied contrived search criteria derived from the research questions, followed by selecting the required research papers, data extraction, and data synthesis, which resulted in 15 de‐motivators from 58 relevant papers. Some of the identified de‐motivators are ‘traditional organizational culture’, ‘lack of agile experts’, ‘reluctance to adopt’, and ‘lack of management and commitment support’. The identified factors have been compared from various perspectives, such as continents, digital libraries, organization size, and so forth.
Elevated PaCO2 Levels Increase Arterial Pulmonary Pressures

BackgroundThe effect of elevated PCO2 in the pulmonary vasculature during mechanical ventilation is not clear. Previous studies in ARDS patients have shown that elevated PaCO2 may be associated with pulmonary hypertension however in models of spontaneously breathing animals results were contradictory.Results In this respect, we aimed to investigate the effect of increased PaCO2 on the pulmonary vasculature of rabbits using different levels of tidal volumes during mechanical ventilation. We conducted an experiment using two groups of adult male rabbits (n=30). Animals were randomly allocated in two groups of different tidal volumes either 6 ml/Kgr (LowVt group) or 9 ml/Kgr (HighVt group) and were ventilated with FiO2 0.3 (Normocapnia-1). Subsequently, animals in each Vt group inhaled an enriched in CO2 gas mixture (FiCO2 0.10.) in order to develop hypercapnia (Hypercapnia-1) and were then re-ventilated with the same conditions to develop subsequent phases of normocapnia and hypercapnia (Normocapnia-2,Hypercapnia-2). Pulmonary arterial pressures were measured with a catheter introduced in the pulmonary artery connected to piezo pressure transducers integrated in a polygraphic system.During hypercapnic conditions , both groups showed increase in PAPsyst, PAPdiast and PAPmean compared to their baseline values. PAPmean pressures increased significantly from Normocapnia-2 to Hypercapnia-2 whereas PAPmean at Hypercapnia-2 was found significantly increased compared to Hypercapnia-1.Conclusions These findings suggests that hypercapnia may augment the pressures in pulmonary vasculature during mechanical ventilation an effect that was observed either, using low or, higher tidal volumes. An effect of preconditioning of arterial pulmonary vessels in hypercapnia merits further investigation.
Justice in Compensation; Family vs. Non-family Business HR Issues

Findings – Results show that while family business employees are less satisfied with benefit packages, their distributive justice perceptions, pay perceptions, and turnover intentions are not significantly different from non-family employees’. Furthermore, moderation analysis reveals that family involvement does not significantly change the relationship level between distributive justice, pay perceptions and turnover intentions.
The Experiences of Sexual and Gender Minorities in Employment: Evidence from a Large-scale Survey of Lesbian, Gay, Bisexual, Transgender and Intersex People in China

Abstract While China's Constitution says everyone is treated equally before the law, employment discrimination continues to exist. This paper breaks new ground by analysing a quantitative survey of more than 10,000 lesbian, gay, bisexual, transgender and intersex (LGBTI) people, the largest dataset of its kind to date in China. Only 5.1 per cent of respondents were completely open about their gender and sexuality at work. More than one-fifth reported experiencing negative treatment in the workplace. Transgender and intersex people reported higher rates of negative treatment, as did respondents with lower educational levels and lower incomes and those residing in towns. Employer policies against discrimination were rare, but when in place, they were significantly associated with less negative treatment. These findings highlight an almost completely neglected segment of the workforce and document discriminatory experiences that could be addressed by changes in discrimination law and by employer policies and practices related to diversity and inclusion.
Prospect Theory and Currency Returns: Empirical Evidence

We empirically investigate the role of prospect theory in the foreign exchange market. Using the historical distribution of exchange rate changes, we construct a currency-level measure of prospect theory value and find that it negatively forecasts future currency excess returns. High prospect theory value currencies significantly underperform low prospect theory value currencies. The predictability is higher when arbitrage is limited and during periods of excess speculative demand of ir- rational traders. These findings are consistent with the hypothesis that investors mentally represent currencies by their historical distributions or charts and evaluate the distribution in the way described by prospect theory.
Prevalence of African trypanosomosis in cattle and sheep in Bassa local government area of Plateau State, Nigeria

A cross-sectional study to determine the prevalence of trypanosomosis in Bassa Local Government Area of Plateau State was carried out on 462 animals (361 cattle and 101 sheep) purposively selected. Blood samples were examined for trypanosomes and the packed cell volume was determined. Biconical traps were set to catch biting flies which were later dissected. The body condition scores of the selected animals were also noted. Out of the 462 blood samples examined, 22 (4.8%) tested positive for trypanosomes. Sheep had higher trypanosome prevalence of 6.9% than cattle 4.2%. The most prevalent species encountered was Trypanosoma vivax (86.4%) followed by T. brucei (13.6%). Trypanosoma vivax was also more predominant in cattle 13 (86.7%) than sheep 6 (85.7%). White Fulani and Red Bororo cattle had 4.2% and 0.0% prevalence, respectively while Yankasa sheep, the only sheep breed sampled, had 6.9%. Male cattle and sheep were more infected with the prevalence rates of 5.0% and 7.4%, respectively than their female counterpart (3.6% for cattle and 6.8% for Sheep). Young cattle ( 2yrs) having the prevalence rates of 3.1% and 4.2% respectively. Poor body conditioned animals had higher trypanosome prevalence (7.3%) than the good body conditioned ones (3.8%). Age, sex, breed and body condition score of animals examined did not influence the infection rate of trypanosome species (p>0.05). The mean PCV ± standard deviation of infected animals (21.73 ± 4.81) was significantly lower than non-infected animals (26.89 ± 4.37) p < 0.05. The study revealed an overall relative low fly density of 0.39 flies/trap/day and flies dissected were negative for trypanosome infection. This present study revealed trypanosome and their vectors are present in the study area. Therefore, improved Veterinary extension services and education should be implemented. Keywords: Bassa, Cattle, Sheep, Prevalence, Trypanosomosis
Comparative Effectiveness of Flotation Technique at Varying Conditions for Beneficiation of Itakpe and Agbaja Iron Ores

Itakpe and Agbaja iron ores are part of prominent iron deposits in Nigeria, yet studies on their beneficiation via froth flotation are relatively limited. Thus, this research investigated comparatively the flotation behaviour of both ores at varied pulp pH, particle size, and collector type. The ores were also examined using Energy Dispersive X-ray Fluorescence Spectroscopy, Petrological, and fractional sieve size analyses. Fifty (50) kg sample each of the ores was sourced for the research. Then, size fractions (63, 75, and 125 mm) of each ore were prepared and subjected to froth flotation using different collectors; Potassium Amyl Xanthate (PAX), Sodium Ethyl Xanthate (SEX), and Oleic Acid, at varying pulp pH ranging from 9-11. From the results obtained Itakpe iron ore assayed 36.18% Fe2O3 and contains predominantly haematite, sillimanite, and quartz while Agbaja iron ore contains chiefly, quartz and haematite, and assayed 40.6% Fe2O3 alongside 1.505% P2O5. The liberation sizes of both ores lie favouraby in the range -125+75 µm. Beneficiation studies carried out revealed that significant enrichment of both ores was actualized. Thus, it was established that Itakpe iron ore is best processed using PAX at pH 11 and particle size of 125 µm yielding concentrates assaying 67.66% Fe2O3 at a recovery of ~90% while for Agbaja iron ore, PAX at pH 9 and particle size of 63 µm is considered best to yield enriched concentrates assaying 65.5% Fe2O3 at 52.5%. recovery.
What Tickles Your Fancy? The Case of Technology and Engineering Students Becoming Entrepreneur

Manuscript type: Research paperResearch aims: This research aims to investigate the factors affectingentrepreneurial intention among technology and engineeringstudents.Design/Methodology/Approach: Quantitative data were collectedfrom 210 students majoring in technology and engineering. Data arethen analysed using Smart PLS.Research findings: Findings indicate that perceived desirability, perceivedfeasibility, need for achievement and need for autonomy havea significant relationship with entrepreneurial intention. This studyhighlights the role of entrepreneurship education programme as themoderating variable among technology and engineering students.Theoretical contribution/Originality: This study expands on existingentrepreneurship literature. It looks at the issue from the perspectiveof technology and engineering students. The study seeks to determinethe role of entrepreneurship education programme as the moderatingvariable.Practitioner/Policy implication: The findings of this study indicatesthe importance of entrepreneurship programme as a platform forgraduate students to develop their entrepreneurial skills, which inturn would encourage them to be an entrepreneur.Research limitation/Implications: Since this study measures entrepreneurialintention rather than entrepreneurs’ actual behaviour,it has to be reminded that intentionality may not necessarily lead toactual behaviour.
Implementation of STEM-Robotics as High School Intra-curricular

The study aim to describe STEM-Robotic implementation as an intra-curricular in regular curriculum. STEM-Robotics is usually implemented as an extracurricular program in many schools. In the 2019/2020 school year, Edu Global Senior High School Bandung implemented STEM-Robotics as an intra-curricular for the ten-grade science program. STEM-Robotic implementation as an intra-curricular based on the challenges of 21st-century learning that lead to innovative creative learning and skills development. The method in this study is descriptive qualitative research method through the observations, questionnaires, and interview with teacher teams. The results of this study show that, 1) The implementation of STEM-Robotic as an intra-curricular has a curriculum that focuses about robots NXT and Arduino to provide the basics of engineering and technological skills in robotics and coding, while the concepts of science and mathematics have not been directly linked in STEM-Robotic, 2) The implementation of STEM-Robotic dominated by hands-on and mind-on activities in the learning process and its assessment. 3) Generally, students responded positively to the implementation of STEM-Robotics as an intra-curricular that makes learning more interesting, useful, fun, challenging, and develop engineering and technology skills. This result indicates that STEM-Robotic is an alternative subject or learning strategy in regular curriculum to accommodate science learning with educational robotics.
Entropy and Intermittency of River Bed Elevation Fluctuations

River beds evolve as a result of a complex interaction between strongly nonlinear processes such as near‐bed turbulence, particle‐particle interaction, and particle‐bed interaction. This interaction contributes to the initiation and evolution of extremely variable river bed elevation patterns, commonly known as bedforms that span across a range of spatiotemporal scales. In this paper, we employ a refined definition of entropy, that is, the multiscale entropy (MSE), to characterize the observed variability in the fluctuations of bed elevation time series under variable discharges obtained from a field‐scale laboratory flume. The MSE accounts for the sequence of data points in a series and quantifies the complexity and lack of information in a system. We show that the MSE of bed elevation fluctuations is higher for higher discharges. When compared with surrogates, which are the linearized series of a signal, the MSE provides across‐scale information about the underlying nonlinearity and linear correlation in a signal. The MSE difference between the original and surrogate series is due to the inherent nonlinearity that is higher for higher discharge at the smaller scales and peaks at intermediate scales. These results indicate the presence of a heterogeneous arrangement of extreme fluctuations that enhances the underlying complexity in bed elevation, rendering them less predictable at higher discharges. We further investigate the role of asymmetry of the bed elevation increments in observed complexity. Our results of asymmetry together with entropy suggest that characteristics of both small‐ and large‐scale features should be included for the accurate predictive modeling of sediment transport.
Aortic valve repair—“Pearls and Pitfalls”

Current medical evidence shows that aortic valve repair reduces valve-related mortality with a better quality of life compared to prosthetic valve replacement. As a result, the 2017 European Association for Cardio-Thoracic Surgeons (EACTS)/European Society of Cardiology (ESC) guidelines for heart valve disease recommend to spare the valve in patients ‘with pliable, non-calcified’ bicuspid or tricuspid aortic valve insufficiency ‘in whom aortic valve repair may be a feasible alternative to valve replacement’ (class IC indication). They also recommend reimplantation or remodeling with aortic annuloplasty for valve-sparing root replacement, referring to the need of addressing the annulus (1). Indeed a dilated aortic annulus ≥25 mm, if left untreated, is clearly documented as a major risk factor for failure of bicuspid and tricuspid aortic valve repair procedures (2,3). As in the case of mitral valve repair, annuloplasty is now considered as an essential component of aortic valve (AV) repair/sparing procedures, aiming at a sustained long-term outcome by reducing the dilated aortic annulus and protecting the repair by improving the surface of coaptation. This review describes the anatomy behind aortic annuloplasty, the different historical techniques, as well as a standardised approach to aortic valve repair with ring annuloplasty according to each aorta phenotype.
Seven Facts about Temporary Layoffs

We establish seven facts about temporary layoffs (TL), whose employers communicated an anticipated recall date at layoff: (1) The higher the current TL share at firm/industry-level, the higher (lower) the future recall (layoff) likelihood for both temporary and permanent layoffs (employees); (2) TL is more prevalent in: the upper-middle part of the wage distribution, (3-4) in mass layoffs and recessions; (5) The later the communicated recall date, the lower the accepted new-job wage, unconditional and conditional on non-employment duration; (6) TLs' new-job hazard rate (wage) jumps (drops) when recall likelihood falls; (7) Extending unemployment benefits increases separations in recall-intense sectors.
Study on knowledge, attitude and practices regarding biomedical waste management among post graduate residents in a tertiary care hospital of Lucknow

Background: It is estimated that 10-25% of the healthcare waste generated is hazardous and presents physical, chemical and/or microbiological risk to the general population and health-care workers associated with handling, treatment, and disposal of waste. All health personnel are expected to have proper knowledge, practice and capacity to guide others for waste collection and management and proper handling techniques. This study was conducted with the aim to assess knowledge, attitude and practices among 1st year post graduate residents in a tertiary care hospital of Lucknow.Methods: It was a hospital based cross-sectional study carried out in March 2017 on 1st year Junior Residents of King George’s medical University, Lucknow. Data was collected using a structured, self-administrated questionnaire, designed to assess the knowledge, attitude and practices on various aspects of bio-medical waste (BMW) management.Results: Majority (72%) of the residents had an average knowledge about BMW management. About one-fourth of them (27.7%) knew about the maximum time beyond which the waste can’t be stored in the hospital while about half of the residents (56.2%) thought that their knowledge regarding biomedical waste is adequate. It was alarming to note that 11.6 percent of the residents were not vaccinated against Hepatitis B.Conclusions: The residents had average knowledge about BMW management, legislation and color coding. The attitude of residents regarding BMW was good but in practice it was average. There is an essential need for better education to improve the practices of BMW management by well-designed seminars, programs and workshops.
Expression of Isocitrate Dehydrogenase-1 (IDH-1) Mutant Protein in Gliomas

Tumors of central nervous system (CNS) are uncommon neoplasms and comprise 1-2% of all the malignancies [1]. gliomas, the most common tumor of the CNS arise from the glia, the supporting cells of the central nervous system. Astrocytes, oligodendrocytes, and ependymal cells are types of glial cells that may give rise to astrocytoma, oligodendrogliomas, and ependymoma respectively. According to World Health Organization (WHO) 2007, these tumors are graded into four grades according to specific histopathological criteria and their biological behaviour ranging from grades I to IV. Glial neoplasmss develop as a result of genetic alterations that continuously accumulate with tumor progression. Molecular signatures of these tumors play roles as diagnostic, prognostic, and predictive markers and influence the clinical decision making process. Various genetic alterations described in the literature include 1p/19q co-deletion, O6-methylguanineDNA methyltransferase (MGMT) promoter hypermethylation and epidermal growth factor receptor (EGFR) alterations. The recent discovery of mutations of the isocitrate dehydrogenase-1 (IDH-1) gene in gliomas, in particular WHO grade II astrocytic, oligodendroglial, oligoastrocytic gliomass, and WHO grade III astrocytic tumors, is pointing toward a potentially common initiating event within this diverse group of tumors. Gliomass harbouring this mutation have been found to be associated with favourable prognosis [2,3].
Digital Communication: Information and Communication Technology (ICT) Usage for Education Sustainability

Today, developments in information and communication technology (ICT) have a significant influence on education sustainability. In this study, the factors influencing students’ intentions towards using ICT in education sustainability, as well as their satisfaction from its use, were examined. This study aims to investigate student intentions to use information and communication technology, as well as their satisfaction with such use. Therefore, this study employed an extended model of the Technology Acceptance Model (TAM) as the research framework, and adopted quantitative data collection and analysis methods by surveying 502 university students who were chosen through stratified random sampling. Using structural equation modeling (SEM), student responses were sorted into eight study constructs and analyzed to explain their intentions towards technology use and satisfaction. A significant relationship was found between computer self-efficacy (CSE), subjective norms (SN), and perceived enjoyment (PE), which were significant determinants of perceived ease of use (PEU) and perceived usefulness (PU). PEU, PU, and attitudes towards computer use (ACU) influenced students’ intentions to use (SIU) ICT and students’ satisfaction (SS). The constructs succeeded in explaining usage intentions towards ICT among students and their satisfaction from this usage.