Miracle-dz/UniFAR-FTUs huggingface dataset:
Evaluation of reporting quality of randomized controlled trials in patients with COVID-19 using the CONSORT statement

Objective To evaluate the reporting quality of randomized controlled trials (RCTs) regarding patients with COVID-19 and analyse the influence factors. Methods PubMed, Embase, Web of Science and the Cochrane Library databases were searched to collect RCTs regarding patients with COVID-19. The retrieval time was from the inception to December 1, 2020. The CONSORT 2010 statement was used to evaluate the overall reporting quality of these RCTs. Results 53 RCTs were included. The study showed that the average reporting rate for 37 items in CONSORT checklist was 53.85% with mean overall adherence score of 13.02±3.546 (ranged: 7 to 22). The multivariate linear regression analysis showed the overall adherence score to the CONSORT guideline was associated with journal impact factor (P = 0.006), and endorsement of CONSORT statement (P = 0.014). Conclusion Although many RCTs of COVID-19 have been published in different journals, the overall reporting quality of these articles was suboptimal, it can not provide valid evidence for clinical decision-making and systematic reviews. Therefore, more journals should endorse the CONSORT statement, authors should strictly follow the relevant provisions of the CONSORT guideline when reporting articles. Future RCTs should particularly focus on improvement of detailed reporting in allocation concealment, blinding and estimation of sample size.
Deconvolution–convolution treatment on powder diffraction data collected with CuKα X-ray and NiKβ filter

A method to remove small CuKβ peaks and step structures caused by NiK-edge absorption as well as CuKα2 sub-peaks from powder diffraction intensity data measured with Cu-target X-ray source and Ni-foil filter is proposed. The method is based on deconvolution–convolution treatment applying scale transform of abscissa, Fourier transform, and a realistic spectroscopic model for the source X-ray. The validity of the method has been tested by analysis of the powder diffraction data of a standard LaB6 powder (NIST SRM660a) sample, collected with the combination of CuKα X-ray source, Ni-foil Kβ filter, flat powder specimen and one-dimensional Si strip detector. The diffraction intensity data treated with the method have certainly shown background intensity profile without CuKβ peaks and NiK-edge step structures.
Clinical assessment of nutritional status using the modified quantified subjective global assessment and anthropometric and biochemical parameters in patients undergoing hemodialysis in Macao

Objective Malnutrition is widespread among patients undergoing hemodialysis and is linked to high morbidity and mortality rates. We evaluated the nutritional status and malnutrition markers in patients undergoing hemodialysis in Macao. Methods We performed a cross-sectional analysis of 360 patients in a hemodialysis center. The modified quantitative subjective global assessment (MQSGA), anthropometric indices and related biochemical test data were used to evaluate nutritional status. Results The sample's mean age was 63.47 ± 13.95 years. There were 210 well-nourished (58.3%), 139 mild-to-moderately malnourished (38.6%) and 11 severely malnourished (3.1%) patients. Older patients had a higher incidence of severe malnutrition, but there were no significant differences between diabetic and non-diabetic patients. Mid-arm circumference (MAC); mid-arm muscle circumference; body mass index; triceps skin fold thickness; serum albumin, creatinine and urea; and hemoglobin were all valid for assessing nutritional status. MAC and the serum albumin and creatinine concentrations significantly negatively correlated with MQSGA. Conclusions Malnutrition is commonplace in patients undergoing hemodialysis in Macao, but their nutritional status is not affected by diabetes. Serum creatinine, serum albumin and MAC, and especially pre-dialysis creatinine concentration, represent effective, readily available, and easily remembered screening measures of nutritional status for patients undergoing maintenance dialysis.
Glial TDP‐43 and TDP‐43 induced glial pathology, focus on neurodegenerative proteinopathy syndromes

Since its discovery in 2006, TAR DNA binding protein 43 (TDP‐43) has driven rapidly evolving research in neurodegenerative diseases including amyotrophic lateral sclerosis (ALS), frontotemporal lobar degeneration (FTLD), and limbic predominant age‐related TDP‐43 encephalopathy (LATE). TDP‐43 mislocalization or aggregation is the hallmark of TDP‐43 proteinopathy and is associated with cognitive impairment that can be mapped to its regional deposition. Studies in human tissue and model systems demonstrate that TDP‐43 may potentiate other proteinopathies such as the amyloid or tau pathology seen in Alzheimer's Disease (AD) in the combination of AD+LATE. Despite this growing body of literature, there remain gaps in our understanding of whether there is heterogeneity in TDP‐43 driven mechanisms across cell types. The growing observations of correlation between TDP‐43 proteinopathy and glial pathology suggest a relationship between the two, including pathogenic glial cell‐autonomous dysfunction and dysregulated glial immune responses to neuronal TDP‐43. In this review, we discuss the available data on TDP‐43 in glia within the context of the neurodegenerative diseases ALS and FTLD and highlight the current lack of information about glial TDP‐43 interaction in AD+LATE. TDP‐43 has proven to be a significant modulator of cognitive and neuropathological outcomes. A deeper understanding of its role in diverse cell types may provide relevant insights into neurodegenerative syndromes.
Is organic chemistry really growing exponentially?

In terms of molecules and specific reaction examples reported in the literature, organic chemistry features an impressive, exponential growth. However, new reaction classes/types that fuel this growth are being discovered at a much slower and only linear (or even sublinear) rate. In effect, the proportion of newly discovered reaction types to all reactions being performed keeps decreasing, suggesting that synthetic chemistry becomes more reliant on reusing the well-known methods. On the brighter side, the newly discovered chemistries are more complex than decades ago, and allow for the rapid construction of complex scaffolds in fewer numbers of steps. In this paper, we study these and other trends in the function of time, reaction-type "popularity" and complexity based on the algorithm that extracts generalized reaction class templates. These analyses are useful in the context of computer-assisted synthesis, machine learning (to estimate the numbers of models with sufficient reaction statistics), and also for identifying erroneous entries in reaction databases.
Biomechanical evaluation of two dorsal and two ventral stabilization techniques for atlantoaxial joint instability in toy-breed dogs.

OBJECTIVE To compare the biomechanical properties of atlantoaxial joints (AAJs) in canine vertebral column specimens stabilized with 4 techniques (dorsal wire, modified dorsal clamp, ventral transarticular pin, and augmented ventral transarticular pin fixation) after transection of the AAJ ligaments. SAMPLE 13 skull and cranial vertebral column segments from 13 cadaveric toy-breed dogs. PROCEDURES Vertebral column segments from the middle aspect of the skull to C5 were harvested and prepared; AAJ ligament and joint capsule integrity was preserved. The atlantooccipital joint and C2 to C5 vertebral column segments were fixed with 2 transarticular Kirschner wires each. The occipital bone and caudalmost aspect of each specimen were embedded in polymethylmethacrylate. Range of motion of the AAJ under shear loading conditions up to 15 N was determined for each specimen during the third of 3 loading cycles with intact ligaments, after ligament transection, and after stabilization with each technique in random order. For each specimen, a load-to-failure test was performed with the fixation type tested last. RESULTS All stabilization techniques except for dorsal clamp fixation were associated with significantly decreased AAJ range of motion, compared with results when ligaments were intact or transected. The AAJs with dorsal wire, ventral transarticular pin, and augmented ventral transarticular pin fixations had similar biomechanical properties. CONCLUSIONS AND CLINICAL RELEVANCE Dorsal wire, ventral transarticular pin, and augmented ventral transarticular pin fixation increased rigidity, compared with results for AAJs with intact ligaments and for AAJs with experimentally created instability. Additional studies are needed to assess long-term stability of AAJs stabilized with these techniques.
Meta‐analysis and Consolidation of Farnesoid X Receptor Chromatin Immunoprecipitation Sequencing Data Across Different Species and Conditions

Farnesoid X receptor (FXR) is a nuclear receptor that controls gene regulation of different metabolic pathways and represents an upcoming drug target for various liver diseases. Several data sets on genome‐wide FXR binding in different species and conditions exist. We have previously reported that these data sets are heterogeneous and do not cover the full spectrum of potential FXR binding sites. Here, we report the first meta‐analysis of all publicly available FXR chromatin immunoprecipitation sequencing (ChIP‐seq) data sets from mouse, rat, and human across different conditions using a newly generated analysis pipeline. All publicly available single data sets were biocurated in a standardized manner and compared on every relevant level from raw reads to affected functional pathways. Individual murine data sets were then virtually merged into a single unique “FXR binding atlas” spanning all potential binding sites across various conditions. Comparison of the single biocurated data sets showed that the overlap of FXR binding sites between different species is modest and ranges from 48% (mouse‐human) to 55% (mouse‐rat). Moreover, in vivo data among different species are more similar than human in vivo data compared to human in vitro data. The consolidated murine global FXR binding atlas virtually increases sequencing depth and allows recovering more and novel potential binding sites and signaling pathways that were missed in the individual data sets. The FXR binding atlas is publicly searchable (https://fxratlas.tugraz.at). Conclusion: Published single FXR ChIP‐seq data sets and large‐scale integrated omics data sets do not cover the full spectrum of FXR binding. Combining different individual data sets and creating an “FXR super‐binding atlas” enhances understanding of FXR signaling capacities across different conditions. This is important when considering the potential wide spectrum for drugs targeting FXR in liver diseases.
Transfusion management of trauma from the 2019 El Paso mass shooting incident

Mortality rates, transfusion ratios, trauma management logistics, and assault characteristics from the El Paso mass shooting incident (MSI) are evaluated in comparison to other MSIs. In 2019, El Paso, TX experienced the eighth‐deadliest MSIs in modern US history. In this 21st mass killing in the United States of 2019, 19 people died immediately, and four of 27 injured, later died from ballistic injuries.
Increased rejection rates in kidney transplantations during the COVID‐19 pandemic

The coronavirus disease-19 (COVID-19) pandemic constitutes a major challenge for transplantation medicine. Given the potential risk of severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) infection and adverse disease courses for recently transplanted recipients, many transplant centers have adapted kidney transplantation programs during the pandemic [1-3]. However, the severity of adaptions considerably differed between countries. Whereas numbers of kidney transplant procedures decreased substantially in the United States, Italy or France [1-3], partially accompanied by changes in early immunosuppressive regimens, countries of the Eurotransplant network virtually maintained transplant activity [4].
Magnetic resonance imaging quantitative T2* mapping to predict the red blood cell content of in vivo thrombi retrieved from patients with large vessel occlusions in acute ischemic stroke

Background and purpose Magnetic resonance imaging quantitative T2* mapping has shown reliable identification of thrombus red blood cell content in vitro. The thrombus composition has been in vivo, associated with outcomes after endovascular therapy for acute ischemic stroke. We aim to analyze the red blood cell content of thrombi retrieved from patients with large vessel occlusions in relation to the thrombus-T2* relaxation time in magnetic resonance imaging. Material and methods Consecutive acute ischemic stroke patients treated by endovascular therapy were scanned with an magnetic resonance imaging quantitative T2* mapping sequence. Quantitative histologic evaluations of red blood cell content were performed. A linear regression assessed the association between vascular risk factors, comorbidities, antithrombotic drugs intake, baseline National Institutes of Health Stroke Scale (NIHSS), intravenous thrombolysis before endovascular therapy, time between onset and groin puncture, patient's outcome at 3 months, magnetic resonance imaging quantitative T2* mapping results, and the red blood cell content of thrombi. The correlation between the mean thrombus-T2* relaxation time and red blood cell content was assessed by calculating the Pearson correlation coefficient. Results Among 31 thrombi, 16 were “Fibrin rich” and 15 “red blood cell dominant. ” The median red blood cell content was 39 (range, 0–90; interquartile range, 37). The median (interquartile range) thrombus-T2* relaxation time was shorter in “red blood cell dominant” thrombi (21, interquartile range 6) than in “Fibrin rich” thrombi (24, interquartile range 7), without significant difference (p = 0.15), as shown in the Box plot. An inverse correlation between thrombus-T2* relaxation time and red blood cell content was found, with a correlation coefficient of −0.41 (95% CI, −0.67 to −0.08, p = 0.02). Conclusion Our study shows that a shorter thrombus-T2* relaxation time is related to a higher red blood cell content within in vivo thrombi.
Using metatranscriptomics to estimate the diversity and composition of zooplankton communities

DNA metabarcoding is a rapid, high‐resolution tool used for biomonitoring complex zooplankton communities. However, diversity estimates derived with this approach can be biased by the co‐detection of sequences from environmental DNA (eDNA), nuclear‐encoded mitochondrial (NUMT) pseudogene contamination, and taxon‐specific PCR primer affinity differences. To avoid these methodological uncertainties, we tested the use of metatranscriptomics as an alternative approach for characterizing zooplankton communities. Specifically, we compared metatranscriptomics with PCR‐based methods using genomic (gDNA) and complementary DNA (cDNA) amplicons, and morphology‐based data for estimating species diversity and composition for both mock communities and field‐collected samples. Mock community analyses showed that the use of gDNA mitochondrial cytochrome c oxidase I (mtCO1) amplicons inflates species richness due to the co‐detection of extra‐organismal eDNA. Significantly more amplicon sequence variants, nucleotide diversity, and indels were observed with gDNA amplicons than with cDNA, indicating the presence of putative NUMT pseudogenes. Moreover, PCR‐based methods failed to detect the most abundant species in mock communities due to priming site mismatch. Overall, metatranscriptomics provided estimates of species richness and composition that closely resembled those derived from morphological data. The use of metatranscriptomics was further tested using field‐collected samples, with the results showing consistent species diversity estimates among biological and technical replicates. Additionally, temporal zooplankton species composition changes could be monitored using different mitochondrial markers. These findings demonstrate the advantages of metatranscriptomics as an effective tool for monitoring diversity in zooplankton research.
Inflammation-Induced Metastatic Colonization of the Lung Is Facilitated by Hepatocyte Growth Factor-Secreting Monocyte-Derived Macrophages

A rate-limiting step for circulating tumor cells to colonize distant organ sites is their ability to locate a microenvironmental niche that supports their survival and growth. This can be achieved by features intrinsic to the tumor cells and/or by the conditioning of a “premetastatic” niche. To determine if pulmonary inflammation promotes the latter, we initiated models for inflammatory asthma, hypersensitivity pneumonitis, or bleomycin-induced sterile inflammation before introducing tumor cells with low metastatic potential into the circulation. All types of inflammation increased the end-stage metastatic burden of the lungs 14 days after tumor cell inoculation without overtly affecting tumor extravasation. Instead, the number and size of early micrometastatic lesions found within the interstitial tissues 96 hours after tumor cell inoculation were increased in the inflamed lungs, coincident with increased tumor cell survival and the presence of nearby inflammation-induced monocyte-derived macrophages (MoDM; CD11b+CD11c+). Remarkably, the adoptive transfer of these MoDM was sufficient to increase lung metastasis in the absence of inflammation. These inflammation-induced MoDM secrete a number of growth factors and cytokines, one of which is hepatocyte growth factor (HGF), that augmented tumor cell survival under conditions of stress in vitro. Importantly, blocking HGF signaling with the cMET inhibitor capmatinib abolished inflammation-induced early micrometastatic lesion formation in vivo. These findings indicate that inflammation-induced MoDM and HGF in particular increase the efficiency of early metastatic colonization in the lung by locally preconditioning the microenvironment. Implications: Inflammation preconditions the distant site microenvironment to increase the metastatic potential of tumor cells that arrive there.
Human SLE variant NCF1-R90H promotes kidney damage and murine lupus through enhanced Tfh2 responses induced by defective efferocytosis of macrophages

Objectives We previously identified a hypomorphic variant, p.Arg90His (p.R90H) of neutrophil cytosolic factor 1 (NCF1, a regulatory subunit of phagocyte nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 2 complex), as an putative causal variant for systemic lupus erythematosus (SLE), and established a knock-in (KI) H90 variant in the C57BL/6 background to study how this variant promotes lupus development. Methods Wild type (WT) and KI littermates were assessed for immune profiles and lupus-like features. Disease activity and renal damage of patients with SLE were assessed by systemic lupus erythematosus disease activity index (SLEDAI) and renal items of systemic lupus international collaborating clinics (SLICC), respectively. Results Compared with WT littermates, 5-week-old homozygous KI mice had reduced oxidative burst, splenomegaly, elevated type I interferon (IFN-I) scores, increased ratios of splenic follicular T helper 2 (Tfh2) to either T follicular regulatory (Tfr) or Tfh1 cells, increased ANA+ follicular, germinal centre and plasma cells without spontaneous kidney disease up to 1 year of age. Pristane treatment exacerbated the immune dysregulation and induced IFN-I-dependent kidney disease in 36-week-old H90 KI female mice. Decreased efferocytosis of macrophages derived from KI mice and patients with homozygous H90 SLE promoted elevated ratios of Tfh2/Tfr and Tfh2/Tfh1 as well as dysregulated humoral responses due to reduced voltage-gated proton channel 1 (Hv1)-dependent acidification of phagosome pH to neutralise the decreased electrogenic effect of the H90 variant, resulting in impaired maturation and phagosome proteolysis, and increased autoantibody production and kidney damage in mice and patients with SLE of multiple ancestries. Conclusions A lupus causal variant, NCF1-H90, reduces macrophage efferocytosis, enhances Tfh2 responses and promotes autoantibody production and kidney damage in both mice and patients with SLE.
High-Temperature Superconducting Phases in Cerium Superhydride with a T_{c} up to 115 K below a Pressure of 1 Megabar.

The discoveries of high-temperature superconductivity in H_{3}S and LaH_{10} have excited the search for superconductivity in compressed hydrides, finally leading to the first discovery of a room-temperature superconductor in a carbonaceous sulfur hydride. In contrast to rapidly expanding theoretical studies, high-pressure experiments on hydride superconductors are expensive and technically challenging. Here, we experimentally discovered superconductivity in two new phases, Fm3[over ¯]m-CeH_{10} (SC-I phase) and P6_{3}/mmc-CeH_{9} (SC-II phase) at pressures that are much lower (<100 GPa) than those needed to stabilize other polyhydride superconductors. Superconductivity was evidenced by a sharp drop of the electrical resistance to zero and decreased critical temperature in deuterated samples and in external magnetic field. SC-I has T_{c}=115 K at 95 GPa, showing an expected decrease in further compression due to the decrease of the electron-phonon coupling (EPC) coefficient λ (from 2.0 at 100 GPa to 0.8 at 200 GPa). SC-II has T_{c}=57 K at 88 GPa, rapidly increasing to a maximum T_{c}∼100 K at 130 GPa, and then decreasing in further compression. According to the theoretical calculation, this is due to a maximum of λ at the phase transition from P6_{3}/mmc-CeH_{9} into a symmetry-broken modification C2/c-CeH_{9}. The pressure-temperature conditions of synthesis affect the actual hydrogen content and the actual value of T_{c}. Anomalously low pressures of stability of cerium superhydrides make them appealing for studies of superhydrides and for designing new superhydrides with stability at even lower pressures.
Occupational hazard perceptions as factors influencing students’ intentions to engage in part-time jobs

Purpose. The purpose of this study was to investigate the joined effects of students’ perceived importance of occupational hazards and financial gains on intentions to engage in part-time jobs. The role of students’ maturity value levels was also investigated. We used conservation of resources theory (COR) and job demands-resources (JD-R) theory as theoretical frameworks to test our hypotheses. Method. We conducted a factorial survey experiment using a sample of 858 students. Multilevel regression analyses with random effects were used to investigate effects of hazards perceptions and financial gains on intentions to engage in part-time jobs. The direct and moderating effects of students’ maturity values were investigated. Results. Students considered financial gains more important in developing their intentions to take a part-time job, compared to occupational hazards. We also found interactions between occupational hazards and between occupational hazards and financial gains in predicting intentions. Students’ maturity scores were negatively related to intentions and moderated the effects of financial gains and perceptions of psychological hazards on intentions. Conclusion. The study provided insights into students’ perceptions of occupational hazards and financial benefits and their intention to take a part-time job. The results also indicate the direct and moderating effects of students’ maturity values.