Miracle-dz/UniFAR-FTUs huggingface dataset:
Capillaroscopic findings in systemic lupus erythematosus with cutaneous digital lesions

Sir, The question about capillaroscopic findings in cutaneous lupus erythematosus (CLE) and systemic lupus erythematosus (SLE) with digital cutaneous lesions is insufficiently studied. The study of Monfort et al. reported presence of “scleroderma-like” pattern significantly more frequently in CLE patients with digital lesions as compared with CLE without digital lesions. These results are of great interest and are analogous to those in cases with SLE, in whom digital vasculitis also correlates significantly with presence of capillaroscopic features of microangiopathy i.e., with “sclerodermalike” pattern. In an own study, digital vasculitis with presence of periungual erythema, macular and petechial rash was present in 3 cases and in 2 of them “scleroderma-like” pattern was observed. In a clinical case of SLE with chilblain lesions of the hands, “scleroderma-like” capillaroscopic pattern was also observed at disease presentation (Figure 1). These observations indicate that presence of clinically-overt local digital vascular pathology is highly associated with “scleroderma-like” capillaroscopic pattern in both CLE and SLE. Cutaneous vascular digital lesions that is expression of local microvessel vasculitis is readily detectable via nailfold capillaroscopy. Although it has been initially suggested that “scleroderma-like” pattern in SLE could be associated with anti-U1RNP antibodies and be a sign of subclinical overlap with systemic sclerosis (SSc), recent observations have demonstrated that microangiopathy could be observed in SLE patients without anti-RNP antibodies positivity and in the absence of an overlap syndrome. “Scleroderma-like” pattern is a relatively nonspecific feature that could be observed in a number of rheumatic diseases different from SSc i.e., SLE, dermatomyositis (DM), rheumatoid arthritis as well as in CLE. Thus, the capillaroscopic diagnosis “scleroderma-like” pattern requires further analysis
Summary of European guidelines on infection control and prevention during COVID‐19 pandemic

Abstract Objectives The current COVID‐19 pandemic highlighted the need for a review of guidelines on infection control and prevention to ensure safe delivery of dental care. However, it is not clear to what extent the rapidly published European guidelines reflect the current evidence and thus provide homogeneous recommendations. Material & Methods Guidelines from all European Union countries, Scotland, Switzerland and United Kingdom were retrieved. Information on triage, mouth rinse, personal protective equipment (PPE) for aerosol free/ generating procedures (non‐AGP/AGP) and treatment of potentially infectious patients were summarized and compared with recommendations from international organizations (WHO, ECDC, CDC). Results All included countries (30/30) published COVID‐19 guidelines in 2020. All countries recommended triage and to postpone non‐urgent treatment of potentially infectious patients. Hydrogen peroxide (1%–1.5%) was the most frequently recommended antiseptic mouth rinse to reduce viral load (24/30). PPE for non‐AGP treatments included mainly surgical masks (21/30) or FFP2/FFP3/N95 masks (16/30), whereas FFP2/FFP3 masks (25/30) and face shields (24/30) were recommended for AGP by the vast majority of guidelines. For high‐risk/COVID positive patients, most countries recommended maximum protection and treatment in specialized dental clinics (22/30). Conclusion There was general agreement among recommendations for triage, mouth rinse, and PPE during AGP and treatment of potentially infectious patients. In contrast, recommendations on PPE for non‐AGP treatment varied considerably among the European countries possibly due to limited scientific evidence regarding transmission risk during non‐AGP treatments.
Intimate partner violence and its association with mental health problems: The importance of childhood violence – The SAMINOR 2 Questionnaire Survey

Aims: This study aims to estimate the prevalence of intimate partner violence (IPV) and its association with psychological distress and symptoms of post-traumatic stress (PTS) among Sami and non-Sami and to explore whether the association between IPV and mental health is modified by exposure to childhood violence (CV). These issues are scarcely studied among the Sami. Methods: This study was based on the cross-sectional SAMINOR 2 Questionnaire Survey, a part of the Population-based Study on Health and Living Conditions in Regions with Sami and Norwegian Populations (SAMINOR). Chi-square tests and two-sample t-tests were used to test differences between groups. Multiple linear regression analysis was applied to explore the association between IPV/CV and continuous scores of psychological distress and symptoms of post-traumatic stress. Results: Experiences of IPV (emotional, physical, and/or sexual) were reported by 12.8% of women and 2.0% of men. A significantly higher proportion of Sami women reported exposure to emotional (12.4 v. 9.5%, p = 0.003), physical (11.6 v. 6.9%, p < 0.001), and any IPV (17.2 v. 11.8%, p < 0.001) compared to non-Sami women. There were no ethnic differences in sexual IPV among women (2%). Exposure to IPV was associated with a higher score of psychological distress and PTS and was highest among those exposed to both IPV and CV. Conclusions: Sami women reported the highest prevalence of IPV. The association between IPV/CV and mental health problems did not differ by ethnicity or gender. The most severe mental health problems were observed for those who were exposed to both IPV and CV.
Intentions to Seek Information about E-Cigarettes: Perceived Risk, Efficacy, and Smoking Identity

While e-cigarette use increases in the US. , people’s knowledge about e-cigarettes is limited. Information seeking may influence people’s knowledge about e-cigarettes. Using the risk perception attitude framework and the identity theory, this study examined if U.S. adult current smokers (n = 1,841) differing in perceived efficacy of switching completely to e-cigarettes, perceived risk of cigarette smoking, and smoking identity report different levels of intentions to seek information about e-cigarettes. Results revealed that smokers with high perceived risk of smoking and perceived efficacy about switching completely to e-cigarettes (responsive group) reported strongest intentions to seek information about e-cigarettes (M = 5.41 on a 1–7 scale), followed by the group having low smoking risk perceptions and high e-cigarette efficacy beliefs (proactive group; M = 4.58), the group having high smoking risk perceptions and low e-cigarette efficacy beliefs (avoidance group; M = 3.18), and the group low on both factors (indifference group; M = 2.76). The differences between responsive group and proactive, avoidance, and indifference groups were greater among smokers with high (M diff = 6.14) vs. low (M diff = 5.27) smoking identity. Theoretical and practical implications of the findings are discussed.
How Czecho-Slovakia Bounces Back: Population-Based Validation of the Brief Resilience Scale in Two Central European Countries

Objective In recent years, resilience has become a focus of research in the medical and behavioral sciences. The Brief Resilience Scale (BRS) was developed to assess the individual ability to recover from stress (“to bounce back”) after experiencing adversities. The aim of the study was to validate the Czech and Slovak versions of the BRS. Methods A representative sample of the Czech and Slovak populations (NCZ = 1800, mean age MCZ = 46.6, SDCZ = 17.4, 48.7% of men; NSK = 1018, mean age MSK = 46.2, SDSK = 16.6, 48.7% men) completed a survey assessing their health and well-being. Several confirmatory factor analysis (CFA) models of the BRS were compared to find the best fit. Cronbach’s alpha and McDonald’s omega coefficients of reliability were evaluated. Convergent validity was assessed by correlating resilience (BRS), physical and mental well-being (SF-8) and psychopathology symptoms (BSI-53). Differences in gender and age groups were appraised. Results A single-factor model with method effects on the reverse items was evaluated to best fit the data in both the Czech and Slovak samples (χ2CZ(6) = 39.0, p < 0.001, CFICZ = 0.998, TLICZ = 0.995, RMSEACZ = 0.055, SRMRCZ = 0.024; χ2SK(6) = 23.9, p < 0.001, CFISK = 0.998, TLISK = 0.995, RMSEASK = 0.054, SRMRSK = 0.009). The reliability was high in both samples (αCZ = 0.80, ωCZ = 0.85; αSK = 0.86, ωSK = 0.91). The BRS was positively associated with physical and mental well-being and negatively associated with somatization, depression and anxiety. In both countries, a lower BRS score was associated with higher age. Czech men reported significantly higher BRS scores than women. No significant difference was found in the mean BRS scores between the two countries. Conclusion This study provides evidence of good psychometric properties, reliability and validity of the Czech and Slovak adaptations of the BRS.
International multicenter, multiplatform study to validate Taipan snake venom time as a lupus anticoagulant screening test with ecarin time as the confirmatory test: Communication from the ISTH SSC Subcommittee on Lupus Anticoagulant/Antiphospholipid Antibodies

Lupus anticoagulant (LA) assays are compromised in anticoagulated patients, and existing strategies to overcome the interferences have limitations. The prothrombin‐activating Taipan snake venom time (TSVT) screening test and ecarin time (ET) confirmatory test are innately insensitive to vitamin K antagonists (VKA) and direct factor Xa inhibitors (DFXaI).
Genome-wide detection of copy number variations in Tharparkar cattle

Abstract Copy number variations (CNVs) are major forms of genetic variation with an increasing importance in animal genomics. This study used the Illumina BovineSNP 50 K BeadChip to detect the genome-wide CNVs in the Tharparkar cattle. With the aid of PennCNV software, we noticed a total of 447 copy number variation regions (CNVRs) across the autosomal genome, occupying nearly 2.17% of the bovine genome. The average size of detected CNVRs was found to be 122.2 kb, the smallest CNVR being 50.02 kb in size, to the largest being 1,232.87 Kb. Enrichment analyses of the genes in these CNVRs gave significant associations with molecular adaptation-related Gene Ontology (GO) terms. Most CNVR genes were significantly enriched for specific biological functions; signaling pathways, sensory responses to stimuli, and various cellular processes. In addition, QTL analysis of CNVRs described them to be linked with economically essential traits in cattle. The findings here provide crucial information for constructing a more comprehensive CNVR map for the indigenous cattle genome.
Encoding of vestibular and optic flow cues to self‐motion in the posterior superior temporal polysensory area

Neurons in the posterior superior temporal polysensory area (STPp) showed significant directional selectivity in response to vestibular, optic flow and combined visual–vestibular stimuli. By comparison to the dorsal medial superior temporal area, the visual latency was slower in STPp but the vestibular latency was faster. Heading preferences under combined stimulation in STPp were usually dominated by visual signals. Cross‐modal enhancement was observed in STPp when both vestibular and visual cues were presented together at their heading preferences.
Invasive Meningococcal Disease, 2011–2020, and Impact of the COVID-19 Pandemic, England

Invasive meningococcal disease incidence in England declined from 1.93/100,000 persons (1,016 cases) in 2010–11 to 0.95/100,000 (530 cases) in 2018–19 and 0.74/100,000 in 2019–20 (419 cases). During national lockdown for the coronavirus disease pandemic (April–August 2020), incidence was 75% lower than during April–August 2019.
APPLICATION OF FOUR IONIC LIQUIDS AS PLASTICIZERS FOR PVC PASTE RESIN

VC paste resin is an important poly(vinyl chloride) product which is applied in artificial leather fabrication, film applicator coatings and medical catheters' production. To make products flexible or just avoid adopting the debated phthalates as plasticizers, four kinds of room temperature ionic liquids (ILs), [omim]PF 6 (1-octyl-3-methylimidazolium hexafluorophosphate), [bupy]PF 6 (1-butyl-pyridine hexafluorophosphate), [C 14 mim]Br (1-tetradecyl -3-methylimidazolium bromide) and [C 16 mim]Br (1-hexadecyl -3-methylimidazolium bromide) were used as plasticizers for PVC paste resin, respectively. The mechanical properties, thermal and photo stabilities of plasticized PVC film samples were investigated by universal testing machine and TG/DTA methods. The results showed that the glass transition temperature (T g ) of 20 wt% of a plasticized sample is lower than that of an unplasticized sample. By increasing plasticizer dosages from 10 wt% to 40 wt%, the tensile strength and elastic modulus of the polymer decreased gradually though its elongation-at-break increased distinctly. The high temperature stability experiments showed that the decomposition temperature and mass loss depend intensively on the composition and structure of the ionic liquids. However, they were slightly affected by the plasticizer content. Moreover, the elongation-at-break measured data proved that ionic liquid-plasticized PVC films display reasonable UV-stability.
Pioglitazone Reverses Alcohol-Induced Alveolar Macrophage Phagocytic Dysfunction

Alcohol use disorders (AUD) increase susceptibility to respiratory infections by 2- to 4-fold in part because of impaired alveolar macrophage (AM) immune function. Alcohol causes AM oxidative stress, diminishing AM phagocytic capacity and clearance of microbes from the alveolar space. Alcohol increases AM NADPH oxidases (Noxes), primary sources of AM oxidative stress, and reduces peroxisome proliferator–activated receptor γ (PPARγ) expression, a critical regulator of AM immune function. To investigate the underlying mechanisms of these alcohol-induced AM derangements, we hypothesized that alcohol stimulates CCAAT/enhancer-binding protein β (C/EBPβ) to suppress Nox-related microRNAs (miRs), thereby enhancing AM Nox expression, oxidative stress, and phagocytic dysfunction. Furthermore, we postulated that pharmacologic PPARγ activation with pioglitazone would inhibit C/EBPβ and attenuate alcohol-induced AM dysfunction. AM isolated from human AUD subjects or otherwise healthy control subjects were examined. Compared with control AM, alcohol activated AM C/EBPβ, decreased Nox1-related miR-1264 and Nox2-related miR-107, and increased Nox1, Nox2, and Nox4 expression and activity. These alcohol-induced AM derangements were abrogated by inhibition of C/EBPβ, overexpression of miR-1264 or miR-107, or pioglitazone treatment. These findings define novel molecular mechanisms of alcohol-induced AM dysfunction mediated by C/EBPβ and Nox-related miRs that are amenable to therapeutic targeting with PPARγ ligands. These results demonstrate that PPARγ ligands provide a novel and rapidly translatable strategy to mitigate susceptibility to respiratory infections and related morbidity in individuals with AUD. Visual Abstract Key Points EtOH activates AM C/EBPβ to suppress miR-1264 and miR-107. Suppression of miR-1264 and miR-107 increases AM Noxes and oxidative stress. PIO reverses EtOH-induced AM oxidative stress and phagocytic dysfunction.
Catechin isolated from faba beans (Vicia faba L.): insights from oxidative stress and hypoglycemic effect in yeast cells through confocal microscopy, flow cytometry, and in silico strategy

Abstract The present aim of this investigation was to evaluate the effect of catechin from faba beans on oxidative stress and glucose uptake in yeast cells. Flow cytometry approach indicated that 2-NBDG (1.98 ± 0.37) seed extract had a lower relative fluorescence signal than methanol (5.98 ± 0.67) and acetone seed extract (4.43 ± 0.55). In comparison to the control and seed extract, H2O2 exposure increased the apoptosis rate of yeast cells from 8.20% to 64.80%. Yeast cells incubated with H2O2 produced significantly more ROS intensity (162 ± 4.32, p < 0.05) than control cells (118 ± 2.52, p < 0.05) and less than seed extract-treated cells. Molecular dynamics simulation studies were performed for cat:α-amylase (catechin-α-amylase complex) which revealed the stable and mixed mode of inhibition during a simulation. The synergistic action of polyphenols or catechin present in seed extract may be responsible for the anti-oxidative stress and hypoglycaemic effects. The findings of this study may provide insight into the further development of a novel antidiabetic drug for T2DM. Communicated by Ramaswamy H. Sarma
Interferon-α as maintenance therapy can significantly reduce relapse in patients with favorable-risk acute myeloid leukemia

Abstract To evaluate the efficacy of interferon-α (IFN-α) as maintenance therapy in patients with favorable-risk acute myeloid leukemia (AML), this retrospective study enrolled 84 patients with favorable-risk AML: 42 patients who received IFN-α maintenance therapy and 42 patients who did not (control). The median follow-up time and duration of IFN-α treatment was 26 (6–54) months and 18 (2–24) months, respectively. The 4-year estimated relapse-free survival (RFS) after the last consolidation chemotherapy was 86.8% (95% confidence interval (CI), 75.8–97.8%) in the IFN-α group and 55.7% (95% CI, 37.2–74.3%) in the control group (p=.007). The 4-year estimated overall survival was 94.4% (95% CI, 86.8–102%) and 76.4% (95% CI, 61.9–90.9%) in IFN-α and control groups, respectively (p=.040). The Cox regression analysis showed that IFN-α treatment was the only independent factor affecting RFS (p=.004). Maintenance therapy with IFN-α may prevent relapse in favorable-risk AML after consolidation chemotherapy.
Racism as an Adverse Childhood Experience: An Interactive Workshop to Train Pediatricians to Address Racism in Clinical Care

This article has supplementary material on the web site: www.jdbp. org. ABSTRACT: Objective: The objective of this study was to address critical gaps in pediatric medical education by developing and evaluating an interactive educational workshop on racism as an adverse childhood experience (ACE). Methods: A team of developmental-behavioral pediatrics professionals used a best-practice curriculum development model of Kern's 6 steps to develop the workshop curriculum. Based on a targeted needs assessment, goals and objectives to address the topics of race and racism in clinical practice were developed. A variety of educational strategies (e.g., audience polls, videos, didactic presentations, experiential activities, and peer-guided case-based discussion and practice) were used to appeal to varied learning styles. Selection of strategies was guided by self-determination theory, an adult learning model that addresses the needs of autonomy, competence, and relatedness. The workshop was implemented at 2 national pediatric meetings and evaluated using participant polls and written program evaluation. Results: The workshop curriculum was well-received. Participants endorsed improvements in comfort level in talking about race/racism and demonstrated a significant change in preparation or comfort level for skills-based activities, including counseling families and offering resources to address experiences with racism, postworkshop. Participants endorsed intent to change clinical practice by discussing the issues of race and indicated a desire to receive additional training. Conclusion: An interactive educational workshop on racism as an ACE was effective in improving pediatric professionals' comfort level and self-rated skills. Desire for a longer educational session suggests receptivity to longitudinal approaches. Replication and refinement of the educational workshop could clarify effective components of this approach. We advocate for longitudinal training curricula that incorporate observable behavior change and skills to increase and further evaluate the impact. Health care provider education and training to implement antiracism efforts in clinical encounters with patients and families can serve as an entry point to the complex process of addressing racism at multiple levels in health care.
Sexting: a potential addiction or an adaptive behavior to COVID-19 social distancing and stay-at-home policies? A qualitative study

Abstract In the early 2020s, the world was challenged by the COVID-19 emergency. Due to the dangerousness of the virus, the main intent of each country involved was to limit the diffusion in order to contain the damage caused by the pandemic. An aspect that has been deeply changed by self-isolation -used as a measure of containment of the virus- is related to sexuality. A practice that assumes importance in this sense is sexting, i.e., the act of sending/receiving sexually explicit messages, photos or videos via device. This practice allows a certain level of intimate behavior while eliminating the possibility of contagion. This study aims - through a qualitative survey - to investigate whether sexting is perceived as a potential addiction or adaptive sexual behavior to social distancing and lockdown policies by COVID-19. In order to do this, 37 subjects aged between 19 and 39 years were recruited - through probability sampling. We used the semi-structured interview method and then, through thematic analysis of the interviews, it emerged that, according to our sample, sexting was perceived to be more of an addiction than an adaptive behavior; despite this, it is possible that the practice of sexting has changed with the current societal situation.
The Impact of Smoking Cessation on Hospitalization and Psychiatric Medication Utilization among People with Serious Mental Illness

Abstract Background: Despite the high prevalence of smoking amongst people with serious mental illness (SMI), referral rates to smoking cessation programs (SCPs) are low. Mental health workers reticence to refer to SCPs has been attributed, in part, to their belief that quitting will have a deleterious effect on their patients’ mental health status. Objectives: This study’s objective was to determine if participating in a smoking cessation program had an adverse effect on mental health status among people with SMI, measured here by a change in hospitalization occurrence or psychiatric medication utilization. People with SMI who had participated in at least one SCP session in a large health maintenance organization (n = 403) were compared to an age-gender-diagnosis matched sample of SMI smokers (1,209) who had never participated. Results: No change in psychiatric hospitalization occurrence pre- versus post-SCP participation was found among participants (Pre:7.2% vs. Post:5.2, p = 0.2) or nonparticipants (Pre:7.0% vs. Post:6.0%, p = 0.2). Mean defined daily dose (DDD) for anti-psychotic, mood stabilizer, anti-depressant and anxiolytic medications also did not change over time for participants and nonparticipants. However, participants who did not complete the SCP and didn’t quit had a 0.35 higher mean DDD for anti-psychotic medications compared with participants who had completed the SCP or quit, and with nonparticipants (p = 0.006), and were the only group to exhibit an increase in mean antipsychotic DDD over time (Pre:1.42, Post:1.63). SCP participation was not associated with hospitalization occurrence or psychiatric medication utilization. Conclusions/Importance: Smoking cessation should be encouraged, with close monitoring during the quit process.