Miracle-dz/UniFAR-FTUs huggingface dataset:
The Family Talk Intervention in Pediatric Oncology: Ill Children’s Descriptions of Feasibility and Potential Effects

Background: There are few scientifically evaluated psychosocial interventions in pediatric oncology, despite the needs for families. The family-based psychosocial intervention “The Family Talk Intervention” (FTI) has shown promising results in other care contexts and was therefore pilot-tested in pediatric oncology. In this study, we examined the experiences of participating in FTI from ill children's perspectives regarding feasibility and potential effects. Methods: This pilot study involved 26 families in pediatric oncology that had participated in FTI. The paper is focused on those ill children who answered surveys (n = 19) and/or participated in interviews (n = 11) when FTI had ended. Data were analyzed with descriptive statistics and thematic analysis. Results: For most ill children, FTI came at the right time, included a reasonable number of meetings, and the length of the meetings was appropriate. The children felt listened to and understood by the interventionists and almost all children reported that FTI had helped them in some way. The children's perceptions indicated that FTI improved communication within the family and strengthened family relations. Children reported that the parents and their siblings seemed to feel better after participation and became more understanding. Discussion: The findings of this pilot study indicated that a full-scale study could be valuable from the ill children's perspective, as FTI was reported as feasible and had positive effects. The findings showed that FTI gave families an opportunity to open up communication about the illness, adjust their behaviors, and strengthen family relationships. Trial registration: ClinicalTrials.gov Identifier NCT03650530.
Denting of coated and uncoated offshore steel pipes

In the present thesis, numerical and experimental investigations of coated offshore pipelines were conducted. The objective was to investigate how the polypropylene coating affected the global response of the pipes. The present work was a continuation of previous theses done on X65 steel pipes without coating, and part of an ongoing research program between SIMLab (NTNU) and Statoil. The experimental work consisted of material testing and component tests. A tensile test of the X65 steel was conducted, along with a compression test of the PP foam from the coating. The component tests consisted of quasi-static denting of pipes with and without coating, and a compression test of the coating component consisting of all the layers combined. Numerical simulations of all the tests were carried out with Abaqus/Explicit. A parameter study with a method called Factorial Design was conducted for the coating component. Dent depths of the bare steel pipes were estimated with the recommended practice, DNV-RP-111. Lastly, a new alternative model that takes the PP coating into account was proposed. The experimental tests showed that for a given level of energy, the coated steel pipes had a significantly lower inner displacement compared to the pipes without coating. The material model for the PP foam underestimated the resistance of the coating. The coating layer in the numerical model initially consisted of one layer based on the PP foam. The Factorial Design indicated that a numerical model including the inner and outer solid PP layers, would not yield a significantly higher resistance. Numerical simulations of the coated steel pipes proved to be difficult. Large deformations in the coating layer lead to contact and distortion problems. The remeshing method ALE improved the simulation significantly, but did not solve the problems with the model entirely. Estimations done on the bare steel pipes with DNV-RP-111 showed good correlation with the experiments, for a displacement up to 5-6% of the outer diameter. The proposed alternative model for the steel pipes with coating seemed to be a good start in exploring how polymer coating can be implemented in a recommended practice or standard.
The hepatoprotective effects of plant-based foods based on the “gut–liver axis”: a prospective review

Abstract The importance of the “gut–liver axis” in the pathogenesis of liver diseases has been revealed recently; which promotes the process of developing preventive and therapeutic strategies. However, considering that there are still many challenges in the medical treatment of liver diseases, potential preventive dietary intervention may be a good alternative choice. Plant-based foods have received much attention due to their reported health-promoting effects in targeting multiple pathways involved in the pathogenesis of liver diseases as well as the relative safety for general use. Based on the PubMed and Web of Science databases, this review emphatically summarizes the plant-based foods and their chemical constituents with reported effects to impact the LPS/TLR4 signaling pathway of gut–liver axis of various liver diseases, reflecting their health benefits in preventing/alleviating liver diseases. Moreover, some plant-based foods with potential gut–liver effects are specifically analyzed from the reported studies and conclusions. This review intends to provide readers an overview of the current progress in the field of this research topic. We expect to see more hepatoprotective measures for alleviating the current prevalence of liver diseases. Graphical abstract
Factors Associated With Undiagnosed Obstructive Sleep Apnea in Overweight and Obese High-Tech Employees: A Multisite Cross-Sectional Study

Background: Being overweight or obese is regarded as crucial risk factors for obstructive sleep apnea (OSA). Objectives: This study aimed to determine the influencing factors of overweight and obese employees with OSA in high-tech workplaces. Methods: A cross-sectional study design was employed. A total of 491 overweight and obese participants were recruited from a large-scale electronics industry. The Chinese version of Pittsburgh Sleep Quality Index, the Epworth Sleep Scale, and a portable sleep monitoring device were used for data collection. Logistic regression analysis was conducted to identify the factors affecting overweight and obese employees with OSA. This study was conducted from August 2019 to July 2020. Results: 60.5% of the overweight and obese participants were found to have OSA, of which 58.9% had mild and 18.5% had severe OSA, respectively. The results showed that age, neck circumference, snoring, and habitual drinking were the crucial factors affecting OSA. Remarkably, age and snoring times showed a significant correlation in predicting OSA of different severities. Neck circumference was an independent risk factor for moderate and severe OSA. Conclusion: More than 60% of the overweight and obese high-tech workplace employees were found to have OSA. We found that the older the age, the larger the neck circumference, a higher number of snoring instances, and drinking were important risk factors for predicting OSA in overweight high-tech employees. The healthcare providers should actively educate OSA-related information for employees in the workplace, and promote high-risk OSA groups to adopt screening based on at-home sleep apparatus.
von Willebrand factor propeptide variants lead to impaired storage and ER retention in patient‐derived endothelial colony‐forming cells

von Willebrand factor (VWF) is synthesized by vascular endothelial cells and megakaryocytes. The VWF propeptide is critical for multimerization and acts as an intra‐molecular chaperone for mature VWF in sorting to its storage organelles, Weibel‐Palade bodies (WPBs). In the Canadian Type 3 VWD study, almost half of the identified variants were in the VWF propeptide and these were associated with an increased bleeding phenotype.
Risk of Appendicitis After mRNA COVID-19 Vaccination in a Danish Population.

Risk of Appendicitis After mRNA COVID-19 Vaccination in a Danish Population Appendicitis has been reported as a potential adverse event after immunization with mRNA-based COVID-19 vaccines, based on trial data,1 adverse event report data,2 and observational data.3 We evaluated the risk of appendicitis after receiving an mRNA COVID-19 vaccination and after diagnosis of SARS-CoV-2 infection compared with the risk of appendicitis in unvaccinated individuals.
Paroxysmal dyskinesia and electrodermal volatility: The role of mindfulness, self-compassion and psychophysiological interventions

Abstract To date, there are no behavioral or psychophysiological treatment studies on paroxysmal dyskinesia (PD). PD is a group of debilitating movement disorders that present with severe episodes of dystonia, chorea, and/or ballistic like movements. This is a first case report of a 50-year-old male who received behavioral interventions (e.g., mindfulness, CBT, and biofeedback interventions) to manage his PD episodes in tandem with multidisciplinary treatments (e.g., neurology, psychiatry, etc.). The paper primarily discusses the serendipitous observation of galvanic skin response (GSR) elevations and spikes immediately before and after the onset of PD episodes. GSR volatility was noted in wave amplitude and wave morphology. Graphs are presented to illustrate GSR volatility associate with PD episodes and the reduction of GSR volatility in response to behavioral approaches. The discussion highlights the feasibility of using GSR biofeedback as an adjunct to mindfulness and CBT to manage PD as part of a multidisciplinary treatment approach. Peripherally, issues that related to misclassification of somatic symptoms and related disorders (e.g., psychogenic non-epileptic seizures) and aspects of neurocognitive disorders are discussed. The paper reviews neurological findings, MRI, neuropsychological data, and psychiatric assessment to highlight the dilemma clinician’s face and clarify behavioral practices to further the management of PD.
Contemporary evidence on colorectal liver metastases ablation: toward a paradigm shift in locoregional treatment

Abstract Image-guided percutaneous ablation techniques represent an attractive local therapy for the treatment of colorectal liver metastases (CLM) given its low risk of severe complications, which allows for early initiation of adjuvant therapies and spare functional liver parenchyma, allowing repeated treatments at the time of recurrence. However, ablation does not consistently achieve similar oncological outcomes to surgery, with the latter being currently considered the first-line local treatment modality in international guidelines. Recent application of computer-assisted ablation planning, guidance, and intra-procedural response assessment has improved percutaneous ablation outcomes. In addition, the evolving understanding of tumor molecular profiling has brought to light several biological factors associated with oncological outcomes following local therapies. The standardization of ablation procedures, the understanding of previously unknown biological factors affecting ablation outcomes, and the evidence by ongoing prospective clinical trials are poised to change the current perspective and indications on the use of ablation for CLM.
Efficiency improvement of WPT system using inexpensive auto-adaptive impedance matching

An inexpensive auto-adaptive impedance matching rectifier for wireless power transfer (WPT) systems is proposed. In most WPT systems, due to environment variations, the received power varies during the time. Owing to nonlinear characteristics of diodes, variation of received power results in impedance mismatch which degrades the efficiency of the system. The proposed rectifier system changes the matching circuit using two switches based on the level of the output voltage. This strategy provides matching in a wide range of power levels and consequently improves the efficiency of the system up to 20%. The proposed rectifier is fabricated and the output DC voltage is measured showing very good agreement with simulation result.
The effect of the COVID‐19 social distancing measures on Turkish women's mental well‐being and burnout levels: A cross‐sectional study

ABSTRACT Lockdown and social distancing measures during the COVID‐19 pandemic increase women's responsibilities and influence their mental health. This study aimed to assess the effect of COVID‐19 social distancing measures on mental well‐being and burnout levels of women using an online cross‐sectional survey in Turkey. The Warwick‐Edinburgh Mental Well‐being Scale, The Burnout Measure, and Sociodemographic form were used in this study. All analyses were performed on a sample of 438 women aged between 18 and 65. The mean score of mental well‐being was 47.86 (SD = 10.04) and the mean score of burnout was 3.86 (SD = 1.16). Being younger than 30 years old (t = 2.14, P = 0.033), having undergraduate education or above (F = 5.09, P = 0.007), part‐time working (F = 5.39, P = 0.005), attending to school (t = 2.68, P = 0.008), having COVID‐19 symptoms (t = 6.01, P < 0.001), and perceiving spousal emotional support (F = 3.47, P = 0.016) were the factors associated with high burnout. Being older than 30 years old (z = −3.11, P = 0.002), full time working (H = 11.96, P = 0.003), not attending to school (z = −2.09, P = 0.036), perceiving spousal emotional (H = 13.22, P = 0.004), or social (H = 13.11, P = 0.004) support were the factors associated with higher mental well‐being. Age (β = −0.03, P = 0.001), having two or more children (β = 0.42, P = 0.015), and perceiving COVID‐19 symptoms (β = −0.73, P < 0.001) were the predictors of women’s burnout. This study shows that mental well‐being and burnout levels of women in Turkey have been considerably affected as a result of social distancing measures taken with the first wave of the pandemic. Findings signal the immediate need for targeted mental health nursing interventions. Therefore, technology‐based mental health support programmes are recommended to be designed and utilized by mental health nurses.
Evaluating a new referral pathway from physical therapists to rheumatologists: A qualitative study

ABSTRACT Early referral to rheumatology of people with suspected inflammatory arthritis is associated with better outcomes. Typically, these individuals are seen by a family physician who would assess the need for rheumatology referral. However, some may first consult a physical therapist where no physician referral is required. New interprofessional referral pathways, such as direct referral from a physical therapist to a rheumatologist, could enhance early access to a rheumatologist. Our objective was to explore perceptions of clinicians and people with inflammatory arthritis regarding physical therapists referring directly to rheumatologists. We used purposive and snowball sampling to recruit participants for five focus groups: rheumatologists, family physicians, physical therapists, people with inflammatory arthritis, and a mixed group of physical therapists and people with inflammatory arthritis. Thematic analysis revealed four core themes: difficulties accessing care, reluctance of family physicians and rheumatologists toward the new pathway, interprofessional relationships (or lack thereof), and opportunities along the referral pathway. The conclusions are that care must be optimized by ensuring swift referral for those who require it; and that there is a need for knowledge translation to all actors on the advantages of this new pathway.
Looking out or Looking Away?—Exploring the Impact of Driving With a Passenger on Young Drivers’ Eye Glance Behavior

Objective To explore how passenger presence and the degree of association between young driver and passenger influences young drivers’ eye glance behavior when they are subjected to distraction. Background Young drivers (18–20 years old) are at an elevated crash risk when subjected to distraction. They are likely to be distracted even further when they drive with passengers. However, the eye glance behavior of these drivers when driving with passengers has not been explored. Method Eye glance data of 34 young drivers between the ages of 18 and 20 years were collected. Participants drove with and without a passenger while subjected to three distracting tasks (visual-manual, cognitive, or visual-cognitive) and driving scenarios that required driver attention. Results Visual-cognitive as well as visual-manual states of distraction result in higher mean and standard deviation of glance duration, along with higher number of glances away from road. Passenger presence is found to negatively influence young drivers’ eye glance behavior. The degree of association between the young driver and the passenger may help reduce the deviation of eye glances towards the task-related objects. Conclusion In addition to distraction, passengers have a negative influence on the eye glance behavior of young drivers. However, a high degree of association between driver and passenger may mitigate the negative impact of distraction on the eye glance behavior of young drivers. Application (non-theoretical works) This research may aid in the design of interventions that improve young drivers’ eye glance behavior when they drive with their peers.
In Streptococcus thermophilus, Ammonia from Urea Hydrolysis Paradoxically Boosts Acidification and Reveals a New Regulatory Mechanism of Glycolysis

Finding that ammonia-generating enzymes, such as urease, and exogenous ammonia act on phosphofructokinase activity shed new light on the regulatory mechanisms that govern glycolysis. Phosphofructokinase is the key enzyme known to exert a regulatory role on glycolytic flux and, therefore, ammonia as an effector of phosphofructokinase acts, in cascade, modulating the glycolytic pathway. ABSTRACT Streptococcus thermophilus is widely used in the dairy industry for the manufacturing of fermented milk and cheeses and probiotic formulations. S. thermophilus evolved from closely phylogenetically related pathogenic streptococci through loss-of-function events counterbalanced by the acquisition of relevant traits, such as lactose and urea utilization for the adaptation to the milk environment. In the context of regressive evolution, the urease gene cluster accounts for 0.9% of the total coding sequence belonging to known functional categories. The fate of ammonia and carbon dioxide derived by urea hydrolysis in several biosynthetic pathways have been depicted, and the positive effect of urease activity on S. thermophilus growth fitness and lactic acid fermentation in milk has been already addressed by several authors. However, the mechanistic effect of urea hydrolysis on the energetic metabolisms of S. thermophilus is still unclear. This study aimed to assess the effect of urease activity on the growth and energy metabolism of Streptococcus thermophilus in milk. In milk, 13C-urea was completely hydrolyzed in the first 150 min of S. thermophilus growth, and urea hydrolysis was accompanied by an increase in cell density and a reduction in the generation time. By using energetically discharged cells with gene transcription and translation blocked, we showed that in the presence of fermentable carbon sources, urease activity, specifically the production of ammonia, could dramatically boost glycolysis and, in cascade, homolactic fermentation. Furthermore, we showed that ammonia, specifically ammonium ions, were potent effectors of phosphofructokinase, a key glycolytic enzyme. IMPORTANCE Finding that ammonia-generating enzymes, such as urease, and exogenous ammonia act on phosphofructokinase activity shed new light on the regulatory mechanisms that govern glycolysis. Phosphofructokinase is the key enzyme known to exert a regulatory role on glycolytic flux and, therefore, ammonia as an effector of phosphofructokinase acts, in cascade, modulating the glycolytic pathway. Apart from S. thermophilus, due to the high conservation of glycolytic enzymes in all branches of the tree of life and being aware of the role of ammonia as an effector of phosphofructokinase, we propose to reevaluate the physiological role of the ammonia production pathways in all organisms whose energy metabolism is supported by glycolysis.
Psychosocial and Drug Use Assessment of Regular vs. Non-Regular Ayahuasca Users in a Brazilian Sample: a Web-Based Survey

Abstract Background: Preliminary evidence suggests that long-term ayahuasca use is associated with better psychosocial outcomes and less drug use; however, available data on the association between ayahuasca intake frequency and psychosocial outcomes is limited. Objectives: We sought to characterize and investigate the association of regular ayahuasca use, as compared to non-regular use, on licit (alcohol and tobacco) and illicit (cannabis, psychostimulants, psychedelics, and non-medical opioids) drug use and psychosocial outcomes. Methods: An online-based cross-sectional survey was taken among people who use ayahuasca in Brazil assessing sociodemographic, drug and ayahuasca use, anxiety and depression (HAD-S), intrinsic religiosity (IRI), negative and positive affects (PANAS), satisfaction with life (SWLS), and five quality of life domains (WHOQOL-Brief). Multivariate regressions for each psychosocial outcome and drug use were performed comparing regular to non-regular ayahuasca users while correcting for sociodemographic variables. Results: A total of 286 valid answers were retrieved, divided into people with regular (n = 101) and non-regular (n = 185) ayahuasca use. Groups had similar sociodemographic profiles and lifetime use of drugs. In the multivariate analysis, regular use of ayahuasca was associated with lower anxiety (B: −0.97), negative affect (B: −2.62), general (B: 0.22) and physical (B: 0.17) quality of life, higher intrinsic religiosity scores (B: 4.16), and less past-month licit (OR = 0.30) and illicit (OR = 0.49) use of substances. Conclusions: Our results show that ceremonial regular ayahuasca compared to non-regular use is associated with better psychosocial and mental health outcomes and less drug use. Studies with repeated ayahuasca administration and extended follow-ups are essential to clarify the nature of ayahuasca’s therapeutic effects and to guide future clinical research.
A Systematic Review of eHealth Interventions to Promote Physical Activity in Adults with Obesity or Overweight

Abstract Use of information and communication technology to improve health, known as eHealth, is an emerging concept in healthcare that may present opportunities to promote physical activity in adults with obesity. The purpose of this research was to systematically review eHealth intervention studies to promote physical activity in adults with obesity. Five electronic databases were used. Two authors screened articles, assessed risk of bias, and extracted data independently. A qualitative data synthesis for summarizing the findings was performed using harvest plots. In the search, 2276 articles were identified, and 18 studies met all inclusion criteria. Study quality ranged from poor to good. The included studies varied in intervention technology (e.g., web-based), physical activity assessment (e.g., device-based), and control group (e.g., wait-list). Behavioral change techniques used in the included studies were consistent with some techniques (e.g., self-monitoring) known as effective in face-to-face interventions, but more efficiently employed in eHealth using information and communication technology. Overall, this systematic review showed that a web-based or physical activity monitor-based eHealth intervention had the potential to effectively promote physical activity in adults with obesity. Some recommendations for future eHealth interventions to promote physical activity in adults with obesity were provided (e.g., use of theory, accelerometers).