Miracle-dz/UniFAR-FTUs huggingface dataset:
Modelling the Physics of Bubble Nucleation in Histotripsy

— This work aims to establish a theoretical framework for the modelling of bubble nucleation in histotripsy. A phenomenological version of the classical nucleation theory was parametrised with histotripsy experimental data, fitting a temperature-dependent activity factor that harmonises theoretical predictions and experimental data for bubble nucleation at both high and low temperatures. Simulations of histotripsy pressure and temperature fields are then used in order to understand spatial and temporal properties of bubble nucleation at varying sonication conditions. This modelling framework offers a thermodynamic understanding on the role of the ultrasound frequency, waveforms, peak focal pressures, and duty cycle on patterns of ultrasound-induced bubble nucleation. It was found that at temperatures lower than 50˚C, nucleation rates are more appreciable at very large negative pressures such as -30 MPa. Moreover, for focal peak negative pressures of -15 MPa, characteristic of boiling histotripsy, nucleation rates grow by 20 orders of magnitude in the temperature interval 60 - 100˚C.
Primary Care of Adult Patients After Stroke: A Scientific Statement From the American Heart Association/American Stroke Association

Primary care teams provide the majority of poststroke care. When optimally configured, these teams provide patient-centered care to prevent recurrent stroke, maximize function, prevent late complications, and optimize quality of life. Patient-centered primary care after stroke begins with establishing the foundation for poststroke management while engaging caregivers and family members in support of the patient. Screening for complications (eg, depression, cognitive impairment, and fall risk) and unmet needs is both a short-term and long-term component of poststroke care. Patients with ongoing functional impairments may benefit from referral to appropriate services. Ongoing care consists of managing risk factors such as high blood pressure, atrial fibrillation, diabetes, carotid stenosis, and dyslipidemia. Recommendations to reduce risk of recurrent stroke also include lifestyle modifications such as healthy diet and exercise. At the system level, primary care practices can use quality improvement strategies and available resources to enhance the delivery of evidence-based care and optimize outcomes.
The impact of COVID-19 pandemic on reproductive intentions among the Polish population.

OBJECTIVES The study was conducted in order to determine the impact of the COVID-19 pandemic on the fertility intentions among the Polish population. MATERIAL AND METHODS A cross-sectional, questionnaire-based online study was carried out among Polish adults in order to determine the impact of the COVID-19 pandemic on the reproductive plans of the Polish society. A total of 984 participants correctly completed the survey. RESULTS The pandemic has affected the reproductive intentions of 22% (n = 216) of the respondents, most of them want to have a child later than they previously planned (74.1%). The relationship between the change in reproductive intentions and the concerns about the pandemic was found. Most of those who changed their plans were afraid that the access to prenatal care and delivery services could be limited (86.6%) or were afraid about giving birth at the hospital (81%). More than half (51.9%) of those who changed reproductive plans were afraid of losing their income and 40.3% had already experienced a decrease in their income. The change in partner's emotional relationships was also observed. More than half of respondents (56.7%) admitted that during the pandemic they had developed a deeper emotional relationship with their partners or felt more emotionally supported (56.6%). Most participants responded that the frequency of their sexual intercourses was not affected (66.7%) and that they had not experienced limited access to contraceptives (95.1%) during the pandemic. CONCLUSIONS The COVID-19 pandemic has affected Polish people's reproductive intentions. Concerns related to healthcare access and the economic difficulties have the most significant impact.
Antecedent infections and vaccinations in chronic inflammatory demyelinating polyneuropathy: A European collaborative study

Chronic inflammatory demyelinating polyneuropathy (CIDP) may be rarely preceded by infection. A causative link remains unproven, in contrast to Guillain‐Barré syndrome (GBS), which is commonly postinfectious with well‐demonstrated pathophysiological mechanisms of molecular mimicry following Campylobacter jejuni enteritis. Uncommonly, infections are reported before the onset of CIDP. In this study we aimed to determine the frequency and characteristics of CIDP occurring after antecedent infections or vaccinations in two large European cohorts.
Epidemiology, Comorbidity and Risk Factors for Psoriatic Arthritis: A Health Insurance Claims Database Analysis

Psoriatic arthritis is a frequent manifestation of psoriasis, and has a high level of impact on physical functioning, work ability and quality of life. However, there have been few studies of the epidemiology, development of and risk factors for concomitant psoriatic arthritis in patients with psoriasis. This study analysed data from a German public health insurance database of > 2 million individuals. Factors influencing the development of psoriatic arthritis were determined by descriptively analysing comorbidities and Cox regression modelling. The prevalences of psoriasis and psoriatic arthritis were 2.63% and 0.29% in adults (18+ years) and, respectively, 0.30% and 0.01% in children (0–17 years). The proportion of adult patients with incident psoriasis who developed concomitant psoriatic arthritis within five years after diagnosis of psoriasis (mean 2.3 years) was 2.6%. Cardiovascular diseases are the most frequent comorbidity in patients with psoriasis with or without concomitant psoriatic arthritis. Depression and neurosis/stress disorder were identified as indicators for the development of psoriatic arthritis.
Diagnostic value of mammography for accompanying non-mass enhancement on preoperative breast MRI

Background Successful surgical treatment for localized breast cancer can depend on accurate diagnosis for accompanying non-mass enhancement (NME) on preoperative breast magnetic resonance imaging (MRI). Purpose To evaluate the diagnostic value of mammography for accompanying NME adjacent to index cancer on preoperative breast MRI Material and Methods Among 569 consecutive patients who underwent preoperative breast MRI from January 2016 to August 2018 for ultrasound-guided biopsy-proven breast cancer, 471 patients who underwent initial mammography and subsequent surgery were finally included. Two radiologists retrospectively reviewed preoperative MRI findings of the 471 patients and detected accompanying NME adjacent to index cancer. MRI, mammography, and histopathology findings of the accompanying NME were evaluated using Pearson’s chi-square test, Mann–Whitney U test, and logistic regression analysis. The area under the receiver operating characteristic curve (AUC) of MRI and combined MRI and mammography was calculated in differentiating benign from malignant accompanying NME. The reference standard was surgical pathologic findings. Results MRI revealed 93 accompanying NME lesions in 92 (19.5%) of the 471 patients, showing 55 (59.1%) malignant and 38 (40.9%) benign lesions. On multivariate analysis, malignant NME lesions were more associated with mammography-positive findings (P = 0.000), clumped or clustered ring internal enhancement (P = 0.015), and extensive intraductal component presence of index tumor (P = 0.007) compared with benign lesions. The AUC increased after correlation with mammography showing 0.649 (95% confidence interval [CI] 0.533–0.765) for MRI and 0.833 (95% CI 0.747–0.919) for combined MRI and mammography. Conclusion Mammography is valuable in predicting malignancy for accompanying NME on preoperative breast MRI.
The effect of type D personality on anxiety, depression and fear of COVID-19 disease in healthcare workers

Abstract During the pandemic, healthcare workers are at the top of the risky groups regarding mental stress. This study aimed to evaluate the relationship of type D personality traits with anxiety, depression, and fear of the SARS-CoV-2 related illness and SARS-CoV-2 virus in healthcare workers during the pandemic period. One hundred ninety-four healthcare workers (53 physicians, 19 dentists, 76 nurses, and 46 auxiliary health personnel) were included in the present study. Sociodemographic Data Form, Type D Personality Scale, Fear of Illness and Virus Evaluation Scale, Beck Depression Inventory, and Beck Anxiety Inventory were applied to the participants. The anxiety, depression, and fear of illness and virus scores were higher in healthcare workers with Type D personality than those without type D personality (respectively; p = 0.001, p = 0.001, and p = 0.001). The Fears about Contamination and Illness, Fears about Social Distancing, Behaviors Related to Virus and Illness Fears, and Impact of Illness and Virus Fears subscale scores and FIVE total scale scores were significantly higher in female healthcare workers than male ones (p = 0.001, for all). Our study results show that Type D personality traits in healthcare workers are associated with higher anxiety, depression, and fear of disease and virus.
Physician experiences in management of COVID‐19‐associated coagulopathy in pregnancy: Communication from the ISTH SSC Subcommittee on Women's Health Issues in Thrombosis and Haemostasis

Coronavirus disease 2019 (COVID‐19) occurs following infection with the potentially fatal, severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) virus. Infection can be complicated by coagulopathy, at times featuring thrombocytopenia and thrombosis alongside other coagulation abnormalities, also termed COVID‐19‐associated coagulopathy (CAC). Data concerning CAC in pregnancy are limited. Better understanding of physician experiences is essential to identify current practice patterns and knowledge gaps.
Economic Evaluations of Artificial Intelligence in Ophthalmology

Abstract Artificial intelligence (AI) is expected to cause significant medical quality enhancements and cost-saving improvements in ophthalmology. Although there has been a rapid growth of studies on AI in the recent years, real-world adoption of AI is still rare. One reason may be because the data derived from economic evaluations of AI in health care, which policy makers used for adopting new technology, have been fragmented and scarce. Most data on economics of AI in ophthalmology are from diabetic retinopathy (DR) screening. Few studies classified costs of AI software, which has been considered as a medical device, into direct medical costs. These costs of AI are composed of initial and maintenance costs. The initial costs may include investment in research and development, and costs for validation of different datasets. Meanwhile, the maintenance costs include costs for algorithms upgrade and hardware maintenance in the long run. The cost of AI should be balanced between manufacturing price and reimbursements since it may pose significant challenges and barriers to providers. Evidence from cost-effectiveness analyses showed that AI, either standalone or used with humans, was more cost-effective than manual DR screening. Notably, economic evaluation of AI for DR screening can be used as a model for AI to other ophthalmic diseases.
Simulation and Experimental Study on Properties of Ag/SnO2 Contact Materials Doped with Different Ratios of Ce

SnO2 in the Ag/SnO2 contact material is a kind of high hardness and almost insulated wide bandgap semiconductor material. In the process of use, the contact resistance is larger and the temperature rise is higher, which reduces the reliability of contacts and shortens the electrical life. In order to improve the properties of Ag/SnO2 contact materials, based on the first principle of density functional theory, this paper presents a method of doping SnO2 with the calculation of different proportions of rare earth Ce electrical and mechanical properties. The results of energy band, density of state, and elastic constant show that when the doping ratio of Ce is 0.125, the electron mobility is the highest, the conductivity is the best; the hardness decreases, and the universal elastic anisotropy index is the smallest. Finally, in the experiment, SnO2 powders with different doping ratios are prepared by the sol-gel method, and Ag/SnO2 contacts with different doping proportions are prepared by powder metallurgy. Arc energy, contact resistance, and hardness are measured; scanning electron microscopy was used to observe and analyze the surface morphology. The final simulation and experimental results are well matched.
Preoperative ventricular late potentials and the risk of adverse events in patients with obstructive hypertrophic cardiomyopathy undergoing septal myectomy.

BACKGROUND Ventricular late potentials (VLPs) detected by signal-averaged electrocardiogram are considered as an indicator of electrical instability in diseased myocardium. Little information exists about the VLPs and their effects on clinical prognosis in patients with obstructive hypertrophic cardiomyopathy (OHCM) undergoing septal myectomy. METHODS Patients with OHCM who underwent septal myectomy from January 2019 to December 2019 were prospectively enrolled. All patients underwent signal-averaged electrocardiogram. Patients were subsequently divided into two groups based on the presence or absence of VLPs. All patients were followed up after surgery to obtain information of survival status and adverse events, including all-cause mortality, congestive heart failure requiring hospitalization, new-onset stroke, and unexplained syncope. RESULTS In total, 128 patients (47.5±12.8 years, 57.8% male) were enrolled. There were 21 (16.4%) individuals in the VLPs-positive group and 107 (83.6%) individuals in the VLPs-negative group. There were no statistically significant differences in non-sustained ventricular tachycardia and late gadolinium enhancement on cardiovascular magnetic resonance images between the two groups. Eight adverse events were reported at the 14.9±4.1 months follow-up. The rates of adverse events in groups of VLPs-positive and VLPs-negative were 23.8% (5/21) and 2.8% (3/107) of cases, respectively. These events included three patients hospitalized for heart failure, two who experienced ischemic strokes, and three with unexplained syncope, respectively. Patients in the VLPs-positive group had a higher risk of adverse events than those in the VLPs-negative group (P<0.001). The presence of positive VLPs (hazard ratio =9.095, 95% confidence intervals: 2.080-39.776, P=0.003) was a strong independent risk factor of adverse events by multivariate Cox regression analysis. Cardiac function Class III or IV, as defined by the New York Heart Association classification, was also an independent risk factor of adverse events (hazard ratio =13.756, 95% confidence intervals: 1.667-113.510, P=0.015). CONCLUSIONS VLPs may increase the risk of adverse events in patients with OHCM after septal myectomy, which may be used as a screening test for further risk stratification.
Vascular endothelial growth factor-A promoter polymorphisms, circulating VEGF-A and survival in acute coronary syndromes

Background Development of a competent collateral circulation in established coronary artery disease is cardio-protective. The vascular endothelial growth factor (VEGF) system plays a key role in this process. We investigated the prognostic performance of circulating VEGF-A and three genetic variants in the VEGFA gene in a clinical coronary cohort. Methods and results The Coronary Disease Cohort Study (CDCS) recruited 2,140 patients, with a diagnosis of acute coronary syndrome (ACS), after admission to Christchurch or Auckland City Hospitals between July 2002 and January 2009. We present data for 1927 patients from the cohort genotyped for three SNPs in the VEGF-A gene, rs699947 (C-2578A), rs2010963 (C405G) and rs3025039 (C936T). Plasma VEGF-A concentrations were assayed in a subgroup (n = 550) of CDCS patients (geometric mean 36.6 [34.7–38.5] pg/ml). VEGF-A levels correlated with patient heart rate at baseline (p = 0.034). None of rs699947, rs3025039, nor rs2010963 genotypes were significantly associated with VEGF-A levels, but rs3025039 genotype was positively associated with collateral vessels perfusion according to the Rentrop classification (p = 0.01) and baseline natriuretic peptide levels (p<0.05). Survival in the CDCS cohort was independently associated with baseline VEGF-A levels and (in males) with rs699947 genotype. Conclusions This study is strongly suggestive that VEGF-A levels have value as a prognostic biomarker in coronary heart disease patients and SNPs in VEGF-A deserve further investigation as prognostic markers and indicators of angiogenic potential influencing the formation of collateral circulation.
Moral Judgment as Categorization (MJAC)

Observed variability and complexity of judgments of “right” and “wrong” cannot be readily accounted for within extant approaches to understanding moral judgment. In response to this challenge, we present a novel perspective on categorization in moral judgment. Moral judgment as categorization (MJAC) incorporates principles of category formation research while addressing key challenges of existing approaches to moral judgment. People develop skills in making context-relevant categorizations. They learn that various objects (events, behaviors, people, etc.) can be categorized as morally right or wrong. Repetition and rehearsal result in reliable, habitualized categorizations. According to this skill-formation account of moral categorization, the learning and the habitualization of the forming of moral categories occur within goal-directed activity that is sensitive to various contextual influences. By allowing for the complexity of moral judgments, MJAC offers greater explanatory power than existing approaches while also providing opportunities for a diverse range of new research questions.
Increased Retinal Vessel Tortuosity Associated With Crimean-Congo Hemorrhagic Fever in Children

Background: To evaluate the ocular symptoms and findings of children diagnosed with Crimean-Congo hemorrhagic fever (CCHF). Methods: In this prospective study, children diagnosed with CCHF who underwent a complete ophthalmologic examination during the hospitalization period were included. Results: Twenty-four children with a mean age of 12.4 ± 3.6 years were included study. The most common ocular finding was conjunctival hyperemia and was observed in 50% of patients. Nine (37.4%) children had abnormalities in fundus examination. Two (8.3%) of them had dilated retinal veins, and 7 (29.1%) had tortuous retinal vessels. No significant difference was found between mild to moderate and severe disease groups in terms of ocular symptoms and ophthalmologic examination findings (P > 0.05, for all). Conclusions: The increased retinal vessel tortuosity was detected as a fundus examination finding in children with CCHF. Both ophthalmologists and pediatricians should be aware of the various ocular manifestations of CCHF for rapid diagnosis and management.
Study on the Stability of Flavonoids from Paulownia Tomentnose Steud Flower

The stability of water solution of flavonoids from paulownia tomentnose steud flower was studied in the different conditions.The natural light has reducing function to the flavonoids,the temperature is no obvious influence,the flavonoids in the condition of pH=5—6 is in stable,and mixing with the carbohydrate is instability,metallic ions K+,Na+,Mg2+,Zn2+,Ca2+ have the stabilization,Al3+,Fe3+ affect obviously,2% H2O2 and Na2SO3 have no obvious influence,2% Vc has more influence.
Aqueous Extract of Lysimachia christinae Hance Prevents Cholesterol Gallstone in Mice by Affecting the Intestinal Microflora

With changes in human dietary patterns, the proportion of high-fat and high-cholesterol foods in the daily diet has increased. As a result, the incidence rate of cholelithiasis is increasing rapidly. Many studies have reported on the crucial role that the intestinal microflora plays in the progression of gallstones. Although the whole herb of Lysimachia christinae, a traditional Chinese medicine, has long been extensively used as a remedy for cholelithiasis in China, its effects on the intestinal microflora remain unknown. Hence, in this study, we investigated the ability of the aqueous extract of L. christinae (LAE) to prevent cholesterol gallstones (CGSs) in model animals by affecting the intestinal microflora. The effects of LAE on body weight, serum lipid profile, visceral organ indexes, and histomorphology were studied in male C57BL/6J mice, which were induced by a lithogenic diet. After the 8-week study, CGSs formation was greatly reduced after LAE treatment. LAE also reduced body weight gain and hyperlipidemia and restored the histomorphological changes. Moreover, the intestinal microflora exhibited significant variation. In the model group fed the lithogenic diet, the abundances of the genera unclassified Porphyromonadaceae, Lactobacillus and Alloprevotella decreased, but in contrast, Akkermansia dramatically increased compared with the control check group, which was fed a normal diet; the administration of LAE reversed these changes. These results imply that L. christinae can be considered an efficient therapy for eliminating CGSs induced by a high-fat and high-cholesterol diet, which may be achieved by influencing the intestinal microflora.
Refinement of the Crystal Structure of the Aragonite Phase of CaCO3.

Aragonite (CaCO3) crystallizes in the unit cell a = 4.9598(5) Å, b = 7.9641(9) Å, and c = 5.7379(6) Å at 25 °C with four formula weights in space-group Pmcn. The structure has been refined to R w = 0.024, R = 0.040 using 765 x-ray reflections from a single crystal. The Ca ion is coordinated to nine oxygens with Ca … O distances in the range 2.414(2) Å to 2.653(1) Å. The two unique C-O distances in the CO3 group are 1.288(2) Å (on the mirror plane) and 1.283(1) Å. The two unique O-C-O angles are 119.6(2)° (across the mirror plane) and 120.13(8)°. The distances and angles in the CO3 group are not significantly different at the 95 percent confidence level.
Association of sarcopenia with incident osteoporosis: a prospective study of 168,682 UK biobank participants

Sarcopenia often co‐occurs with osteoporosis in cross‐sectional studies. However, this association has rarely been studied in prospective studies. This study aimed to investigate the association between sarcopenia categories—along with its individual components—and incident osteoporosis in both middle‐aged and older men and women from the UK Biobank study.