Miracle-dz/UniFAR-FTUs huggingface dataset:
Unpacking the Microdynamics of Multiplex Peer Developmental Relationships: A Mutuality Perspective

Peer developmental relationships—informal arrangements between pairs of individuals who take an active interest in and concerted action to advance one another's careers—offer a valuable alternative to formal mentorships. Despite recognition that peer developmental relationships have the potential to jointly provide career and psychosocial support (i.e., multiplexity) and that relationships embodying multiple support dimensions are indispensable, a paucity of work investigates what factors contribute to their dynamics and persistence over time. To address this issue, we integrate the microfoundations of network dynamics and mutuality perspectives to identify why and when social processes—specifically, reciprocity, trust, and trust asymmetry—operate to form, strengthen, or maintain multiplex peer developmental relationships. To test our hypotheses, we collected three waves of data over one-and-a-half years from a cohort of individuals participating in a leadership development program. Using variations of the Quadradic Assignment Procedure (QAP) to investigate dyad-level dynamics, our results generally suggest that (over and above demographics and network characteristics) the provision of psychosocial support relatively early in the peer-to-peer relationship is likely to evolve into a more complex, high-quality relationship comprised of both psychosocial support and career support (i.e., a multiplex peer developmental relationship). Perhaps more importantly, the social processes capturing mutuality further increased the likelihood that multiplex developmental relationships would develop and persist over time. Our results demonstrate that mutuality is both generative and resolute in nurturing multiplex developmental relationships.
Allogeneic Stem Cell Transplantation in Multiple Myeloma

Simple Summary Due to its graft-versus-myeloma effect, allogeneic hematopoietic stem cell transplantation (allo-SCT) can enable long-term survival or even cure in carefully selected patients with multiple myeloma (MM), but remains controversial due to its relevant treatment-related toxicity. Current data suggest that allo-SCT should be considered in young MM-patients without relevant comorbidities in case of a high-risk constellation according to cytogenetics or stage, primarily as part of a tandem approach with autologous-SCT followed by allo-SCT and early in the course of the disease. Prospective studies are warranted, due to a suspected synergism especially those including new immunotherapeutic approaches for induction, conditioning and maintenance therapy. Abstract The development of new inhibitory and immunological agents and combination therapies significantly improved response rates and survival of patients diagnosed with multiple myeloma (MM) in the last decade, but the disease is still considered to be incurable by current standards and the prognosis is dismal especially in high-risk groups and in relapsed and/or refractory patients. Allogeneic hematopoietic stem cell transplantation (allo-SCT) may enable long-term survival and even cure for individual patients via an immune-mediated graft-versus-myeloma (GvM) effect, but remains controversial due to relevant transplant-related risks, particularly immunosuppression and graft-versus-host disease, and a substantial non-relapse mortality. The decreased risk of disease progression may outweigh this treatment-related toxicity for young, fit patients in high-risk constellations with otherwise often poor long-term prognosis. Here, allo-SCT should be considered within clinical trials in first-line as part of a tandem approach to separate myeloablation achieved by high-dose chemotherapy with autologous SCT, and following allo-SCT with a reduced-intensity conditioning to minimize treatment-related organ toxicities but allow GvM effect. Our review aims to better define the role of allo-SCT in myeloma treatment particularly in the context of new immunomodulatory approaches.
Monetary Valuation of a Quality-Adjusted Life Year (QALY) for Depressive Disorders Among Patients and Non-Patient Respondents: A Matched Willingness to Pay Study

Background As estimated by the World Health Organization, depressive disorders will be the leading contributor to the Global Burden of Disease by 2030. In light of this fact, we designed a study whose aim was to investigate whether the value placed on health-related quality of life (HRQoL) for a depressive disorder is higher in patients diagnosed with a major depressive disorder (MDD) compared to non-patients in a matched sample. Method We collected data on willingness to pay (WTP) for a total of four health-gain scenarios, which were presented to 18 outpatients diagnosed with a MDD versus 18 matched non-patient respondents with no symptoms of depression. Matching characteristics included age, income, level of education, and type of health insurance. Respondents were presented with different HRQoL scenarios in which they could choose to pay money to regain their initial health state through various treatment options (e.g., inpatient treatment, electroconvulsive therapy). To test whether the probability of stating a positive WTP differed significantly between the two samples, Fisher’s exact test was used. Differences regarding stated WTP between the samples were investigated using the Mann-Whitney U-test. Results For most of the health scenarios, the probability of stating a positive WTP did not differ between the two samples. However, patient respondents declared WTP values up to 7.4 times higher than those stated by matched non-patient respondents. Conclusion Although the perceived necessity to pay for mental-HRQoL gains did not differ between respondents with MDD and respondents with no symptoms of depression, patient respondents stated higher values.
A prediction-error-based method for data transmission and damage detection in wireless sensor networks for structural health monitoring

In this work, a prediction-error-based method that aims to reduce the amount of data transmission and storage in structural health monitoring wireless sensor networks (WSN) while keeping the damage detection capabilities intact is presented. WSNs offer tremendous promise for accurate and continuous structural monitoring using a dense array of inexpensive sensors and possess many advantages over conventional wired systems, particularly for large civil infrastructures. This paper validates the studied approach with the data collected during a test on a three-story steel frame mounted at the ELSA laboratory of the EU Joint Research Center in Ispra, Italy. The frame is tested with and without steel bracing, which results in non-sway behavior and sway frame responses. The excitation is provided by a shaker mounted on top of the frame. Accelerometer signals are collected by a multi-channel data acquisition system. The proposed method has been tested extensively via recorded experimental data and it offers considerable saving in transmitted energy while at the same time keeping the ability to detect changes or damage in the structure.
Mechanical Properties and Bond Strength of Additively Manufactured and Milled Dental Zirconia: A Pilot Study.

PURPOSE To evaluate and compare the mechanical properties and ceramic bond of additively manufactured and milled dental zirconia materials. MATERIALS AND METHODS Disc (r = 10 mm, h = 2 mm) and bar (254) shaped milled (M group) (Nacera Pearl; Doceram) and additively manufactured (AM group) (NanoParticul Jetting; XJet, Carmel 1400) zirconia specimens were prepared for 2 experimental groups. Ceramic was applied to the disc specimens (h = 4 mm, r = 6 mm) (n =9) and their shear bond strength (SBS) was measured. The surface morphology of disc specimens was analyzed with a scanning electron microscope (SEM). The Vickers microhardness (Vh), surface roughness (Ra), and three-point flexural strength (FS) of bar specimens (n = 9) were measured. Results were statistically analyzed with Mann-Whitney U-test (α = 0.05) RESULTS: : Significant differences were found in FS and Vh values of the M and AM groups. M group (1501.4 ± 60.1 HV1) showed a significantly higher Vh value than the AM group (1169.2 ± 48.4 HV1) (p < 0.001). FS of the M group (1287.5 ± 115.2 MPa) exhibited significantly high value than the AM (1030.0 ± 29.2 MPa) group (p < 0.001). Statistically, no significant differences were seen in SBS and Ra values of the M and AM groups. CONCLUSION Within the limitations of this in vitro study, the manufacturing technique affected the mechanical properties of the zirconia materials. AM zirconia material showed lower Vh and FS values than M zirconia. Additionally AM zirconia demonstrated adequate bond strength with dental ceramic. This article is protected by copyright. All rights reserved.
Estimating cell-type-specific gene co-expression networks from bulk gene expression data with an application to Alzheimer’s disease

Inferring and characterizing gene co-expression networks has led to important insights on the molecular mechanisms of complex diseases. Most co-expression analyses to date have been performed on gene expression data collected from bulk tissues with different cell type compositions across samples. As a result, the co-expression estimates only offer an aggregate view of the underlying gene regulations and can be confounded by heterogeneity in cell type compositions, failing to reveal gene coordination that may be distinct across different cell types. In this paper, we describe a flexible framework for estimating cell-type-specific gene co-expression networks from bulk sample data, without making specific assumptions on the distributions of gene expression profiles in different cell types. We develop a novel sparse least squares estimator, referred to as CSNet, that is efficient to implement and has good theoretical properties. Using CSNet, we analyzed the bulk gene expression data from a cohort study on Alzheimer’s disease and identified previously unknown cell-type-specific co-expressions among Alzheimer’s disease risk genes, suggesting cell-type-specific disease pathology for Alzheimer’s disease.
Development of a Mechanistic Method to Obtain Load Position Strain in Instrumented Pavement

To study the in-situ response and performance of asphalt pavement, instrumenting pavement with a variety of sensors has become one of the most important tools in the field or accelerated load facilities. In the dynamic response collection process, engineers are more concerned with the load position strain of the pavement structure due to wheel wander. This paper proposes a method to obtain the load position and the strain at the load position when there is no lateral-axis positioning system based on multilayer elastic theory. The test section was paved in the field with installed strain sensors to verify and apply the proposed method. The verification results showed that both the calculated load position and load position strain matched the measured values with an absolute difference range of 5–60 mm, 0.5–2.5 με, respectively. The application results showed that the strain at the load position calculated by the proposed method had a good correlation with the temperature, as expected.
Barriers and Facilitators for Exclusive Breastfeeding within the Health System and Public Policies from In-Depth Interviews to Primary Care Midwives in Tenerife (Canary Islands, Spain)

The aim of this study is to describe the perspectives of Primary Care midwives regarding factors that benefit or are detrimental to exclusive breastfeeding (EBF) within the health system and public policies. The study was carried out in Tenerife (Canary Islands, Spain) and is based on qualitative methodology. Twenty in-depth interviews were carried out with midwives who work in Primary Care centres in Tenerife, using a content analysis approach. The transcript data were then encoded following an inductive approach. The factors, according to midwives, that affect EBF, with regard to the healthcare system, are related to training of healthcare professionals in breastfeeding and their support to women during pregnancy, childbirth and postnatal care. Regarding public policies, midwives believe the maternity leave periods in Spain, together with a lack of laws and social policies to protect EBF are detrimental. The findings from our study show that there is a need to boost training and the role of professionals in EBF and, at the same time, promote protective policies that foster equality, favouring, among other issues, the work-life balance.
Alveolar Bone Morphotype in Orthodontic Patients

Orthodontic treatments have been described as a risk factor for the development of gingival recessions. This descriptive and cross-sectional study was performed to evaluate the alveolar bone morphotype of the upper and lower anterior of 33 orthodontic treatment of candidate patients. The images were obtained from a high-resolution cone beam computerised tomography. Then, the thickness of the alveolar bone plate of teeth was measured in six levels, recording the presence of dehiscences and fenestrations. A total of 2,334 sites were evaluated. The average thickness of the maxillary alveolar bone at the buccal surface was 0.70, 0.62 and 1.43 mm at the cervical, middle and apical levels, respectively, while in the mandibular teeth it was 0.53, 0.50 and 2.96 mm. At the palatal and lingual surfaces, the bone was thicker than the buccal except at the apical level of the mandible. Most of the examined sites were measured less than 1 mm (n = 1,235, 52.9%), associated with high prevalence of bone dehiscences (57.6%) and fenestrations (33.3%), particularly in skeletal Class III patients. The observed bone morphotype involved a high vulnerability to bone resorption, and the subsequent gingival recession occurrence, face to orthodontic movements.
‘Why Should I Take the COVID-19 Vaccine after Recovering from the Disease?’ A Mixed-methods Study of Correlates of COVID-19 Vaccine Acceptability among Health Workers in Northern Nigeria

ABSTRACT We assessed the acceptability of COVID-19 vaccine, predictors, and reasons for vaccine hesitancy among clinical and non-clinical staff at a tertiary hospital in Kano, northern Nigeria. Using a mixed-methods design, structured questionnaires were administered to 284 hospital staff, followed by 20 in-depth interviews with a purposive sub-sample. Logistic regression and the framework approach were used to analyze the data. Only 24.3% (n = 69) of the respondents were willing to accept the COVID-19 vaccine. Acceptance was lower among females (Adjusted Odds Ratio (aOR) = 0.37, 95% Confidence Interval (95%CI): 0.18–0.77 (male vs. female), nurses/midwives (aOR = 0.41, 95%CI:0.13–0.60, physicians vs. nurses/midwives), persons not tested for COVID-19 (aOR = 0.32, 95%CI 0.13–0.79) (no vs. yes) and those who perceived themselves to be at low risk of COVID-19 (aOR = 0.47, 95%CI,0.21–0.89, low vs. high). In contrast, vaccine acceptance was higher among more experienced workers (aOR = 2.28, 95%CI:1.16–8.55, ≥10 vs. <5 years). Vaccine acceptance was also higher among persons who did not worry about vaccine efficacy (aOR = 2.35, 95%CI:1.18–6.54, no vs. yes), or about vaccine safety (aOR = 1.76, 95%CI: 1.16–5.09, no vs. yes), side effects (aOR = 1.85, 95%CI:1.17–5.04, no vs. yes), or rumors (aOR = 2.55, 95%CI:1.25–5.20, no vs. yes). The top four reasons for vaccine hesitancy included distrust, inadequate information, fear of long-term effects, and infertility-related rumors. Concerted efforts are required to build COVID-19 vaccine confidence among health workers in Kano, Nigeria.Our findings can help guide implementation of COVID-19 vaccination in similar settings.
Niche Packing and Local Coexistence in a Megadiverse Guild of Frugivorous Birds Are Mediated by Fruit Dependence and Shifts in Interaction Frequencies

Niche packing is one of the prevailing mechanisms underlying the increase in the number of co-occurring species and the extraordinary diversity of tropical ecosystems. However, it is not yet understood whether niche packing is facilitated by higher specialization and reduced niche overlap or, rather, by diffuse competition and increased niche overlap. We combined highly resolved bird-plant interaction networks, bird phylogenies, and plant functional traits to compare dietary niche overlap and foraging frequencies among frugivorous birds at seven sites in the tropical Andes. We quantified niche overlap on the basis of the traits of the plants used by each bird and related it to the degree of niche packing at the different sites. Niche complementarity decreased with increasing niche packing, suggesting that increasingly dense niche packing is facilitated by increased niche overlap. Pairwise niche overlap was mediated by shifts in foraging frequencies away from shared resources, and it decreased with decreasing phylogenetic relatedness and increasing dependence on fruit as resource. Our findings suggest that foraging choices are a key axis of diversification in frugivorous birds and that differences in resource use frequencies are already sufficient to reduce potential competition between ecologically similar species and facilitate niche packing, especially if species differ in their dependence on particular resources.
Direct Surface Integral Equation-Based Characteristic Mode Formulation for Composite Metallic-Dielectric Structures

We propose a new surface integral equation-based characteristic mode formulation for composite metallic-dielectric structures, in which all equivalent currents are directly solved without any process of current elimination. Thus the proposed formulation is in a compact form that is easy to be implemented for complex objects, especially for multi-layer structures. Numerical results validate the new formulation.
Measurement of Equilibrium Factor ”F” between Radon and its Progeny and Thoron and its Progeny in the Indoor Atmosphere Using Nuclear Track Detectors

Radon, thoron and their progeny are present in the indoor atmosphere as attached and unattached fractions. The level of ventilation in a house and the plating out of radon/thoron daughters onto surfaces decide the extent of equilibrium between them. Since the daughter products are mainly responsible for the inhaled dose, the measurement of the equilibrium factor, F, between radon/thoron and their progenies is desirable. It is therefore necessary to measure the equilibrium factor for different types of house construction, locations and seasons before projecting the dose from the measurements of radon and thoron. This paper presents the results of the measurement of F between radon, thoron and their progenies in dwellings using the LR-115 type II plastic track detector. The exposures were made with a twin-chamber dosimeter in about 150 houses of different types, distributed at different locations in the Garhwal and Kumaun region of the Himalayas in India. The measured equilibrium factor between radon and progeny varied from 0.02 to 0.90 with an average value of 0.28 while the same factor for thoron and progeny was found to vary from 0.01 to 0.90 with an average value of 0.09. The methods of measurement and results obtained are discussed in detail.
The Effect of Human Resources Competencies and Internal Controlling System on the Quality of Accounting Information System and Their Impacts to the Quality of Financial Reporting

This study aims to determine the effect of human resources competencies and internal controlling systems on the quality of accounting information systems and to deter-mine the quality of financial reporting. This study is a quantitative study with primary data obtained from 105 respondents from the finance/administration/budget division of the DKI Jakarta Provincial Government SKPD who collected 52 SKPD. Partial Least Square is used as an analytical tool in this study.The results showed that the competence of human resources and internal controlling systems directly have a significant effect on the quality of accounting information systems and the quality of accounting information systems have a significant effect on the quality of financial reporting.
Visual Function and Visual Perception among Senior Citizens with Mild Cognitive Impairment in Taiwan

Purpose: With the benefits of advanced medical technology, Taiwan has gradually changed from an aged society to a super-aged society. According to previous studies, the prevalence rate of mild cognitive impairment (MCI) over the age of 60 is 15% to 20%. Therefore, the main purpose of our study was to analyze the correlation of cognitive function with visual function (specifically, binocular vision and visual perception) in Taiwanese volunteers aged 60 years or older. Methods: Thirty-six healthy participants who were not taking psychiatric medications and who had not been diagnosed with any retinal or optic nerve diseases were enrolled. Addenbrooke’s cognitive examination III (ACE-III), binocular visual function, and visual perception evaluation were performed, and the data analyzed statistically by t-test, χ2, linear regression, and MANOVA. Results: Cognitive function was closely correlated with visual function and visual perception; the horizontal adjustment time of binocular eye movement, stereopsis, the motor-free visual perception test-4 (MVPT-4), and peripheral awareness actually displayed higher explanatory power in predicting cognitive function. In addition, various interactive parameters between visual function and visual perception were found to affect specific aspects of ACE-III. Discussion: Our study revealed that there was a close correlation of cognitive function with visual function; as such, it may be possible to predict visual function deficits in patients with mild cognitive impairment.