Miracle-dz/UniFAR-FTUs huggingface dataset:
Trioxolone Methyl, a Novel Cyano Enone-Bearing 18βH-Glycyrrhetinic Acid Derivative, Ameliorates Dextran Sulphate Sodium-Induced Colitis in Mice

Semi-synthetic triterpenoids, bearing cyano enone functionality in ring A, are considered to be novel promising therapeutic agents with complex inhibitory effects on tissue damage, inflammation and tumor growth. Previously, we showed that the cyano enone-containing 18βH-glycyrrhetinic acid derivative soloxolone methyl (SM) effectively suppressed the inflammatory response of macrophages in vitro and the development of influenza A-induced pneumonia and phlogogen-stimulated paw edema in vivo. In this work, we reported the synthesis of a novel 18βH-glycyrrhetinic acid derivative trioxolone methyl (TM), bearing a 2-cyano-3-oxo-1(2)-en moiety in ring A and a 12,19-dioxo-9(11),13(18)-dien moiety in rings C, D, and E. TM exhibited a high inhibitory effect on nitric oxide (II) production by lipopolysaccharide-stimulated J774 macrophages in vitro and dextran sulfate sodium (DSS)-induced colitis in mice, displaying higher anti-inflammatory activity in comparison with SM. TM effectively suppressed the DSS-induced epithelial damage and inflammatory infiltration of colon tissue, the hyperproduction of colonic neutral mucin and TNFα and increased glutathione synthesis. Our in silico analysis showed that Akt1, STAT3 and dopamine receptor D2 can be considered as mediators of the anti-colitic activity of TM. Our findings provided valuable information for a better understanding of the anti-inflammatory activity of cyano enone-bearing triterpenoids and revealed TM as a promising anti-inflammatory candidate.
Signal detection with quantization noise based on compressive sensing acquisition system

To promote the efficient use of spectrum resources, cognitive radio (CR) has been proposed. Spectrum sensing is the core technology of CR. In spectrum sensing, idle frequency bands should be detected for secondary users. Signal detection in spectrum sensing is a recent active research topic. Conventional spectrum sensing methods are based on Nyquist sampling and have high hardware requirements, thus limiting the use of these methods. The proposed compression sampling theory can overcome the limitation of Nyquist sampling and can solve this problem. In high-speed sampling, the effect of quantization noise is becoming more significant. In this paper, we study the signal detection in compressed sampling under the influence of quantization noise. Since the quantization noise is related to the quantization bits, we derive the relationship between the quantization bits and the detection rate (PD). We also consider the input noise and investigate its impact on signal detection. Due the amplification of input noise in compressive sampling process, in comparison to the quantization noise, the input noise exhibits more serious impact on detection performance.
Genetic Variations of RAD51 and XRCC2 Genes Increase the Risk of Colorectal Cancer in Bangladeshi Population

Objectives: In case of Bangladeshi population, no report is observed till now showing the genetic variations of RAD51 (rs1801320) and XRCC2 (rs3218536) genes polymorphism having association with colorectal cancer risk. For this reason the aim of this study is to ascertain their interrelation with colorectal cancer occurrence in Bangladeshi population. Materials and Methods: A case control study was conducted where 200 colorectal cancer patients and 200 healthy volunteers were figured for this research using Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP). Results: Here, in case of RAD51 (rs1801320), G/C heterozygous genotype was found significant (p=0.037; OR=1.64; 95% CI=1.03 to 2.6). On the other hand, G/G genotype was not found statistically significant (p=0.423; OR=1.61; 95% CI=0.49 to 5.22) and significance was observed for GC+GG (p=0.030; OR=1.63; 95% CI=1.05 to 2.55). In case of XRCC2 (rs3218536), C/T heterozygous genotype was remarked statistically significant (p=0.033; OR=1.60; 95% CI=1.04 to 2.46). The T/T genotype was not recorded statistically significant (p=0.237; OR=1.65; 95% CI=0.72 to 3.76) but significance found for CT+TT (p=0.027; OR=1.61; 95% CI=1.05 to 2.45). Moreover, it is found that the risk factor of developing CRC is observed in G/C, C/T heterozygote and GC+GG, CT+TT (heterozygote+ mutant) in RAD51 (rs1801320) and XRCC2 (rs3218536) respectively although no significance is observed in case of G/G and T/T mutant. Conclusions: So, the association of RAD51 (rs1801320) and XRCC2 (rs3218536) genes polymorphism with colorectal cancer risk is observed in Bangladeshi population.
Tight typings and split bounds, fully developed

Abstract Multi types – aka non-idempotent intersection types – have been used. to obtain quantitative bounds on higher-order programs, as pioneered by de Carvalho. Notably, they bound at the same time the number of evaluation steps and the size of the result. Recent results show that the number of steps can be taken as a reasonable time complexity measure. At the same time, however, these results suggest that multi types provide quite lax complexity bounds, because the size of the result can be exponentially bigger than the number of steps. Starting from this observation, we refine and generalise a technique introduced by Bernadet and Graham-Lengrand to provide exact bounds. Our typing judgements carry counters, one measuring evaluation lengths and the other measuring result sizes. In order to emphasise the modularity of the approach, we provide exact bounds for four evaluation strategies, both in the λ-calculus (head, leftmost-outermost, and maximal evaluation) and in the linear substitution calculus (linear head evaluation). Our work aims at both capturing the results in the literature and extending them with new outcomes. Concerning the literature, it unifies de Carvalho and Bernadet & Graham-Lengrand via a uniform technique and a complexity-based perspective. The two main novelties are exact split bounds for the leftmost strategy – the only known strategy that evaluates terms to full normal forms and provides a reasonable complexity measure – and the observation that the computing device hidden behind multi types is the notion of substitution at a distance, as implemented by the linear substitution calculus.
NONDESTRUCTIVE TRACING OF MIGRATORY RHYTHMS OF INTERTIDAL BENTHIC MICROALGAE USING IN VIVO CHLOROPHYLL A FLUORESCENCE 1, 2

In vivo chlorophyll (Chl) a fluorescence was measured in undisturbed intertidal sediments with the purpose of tracing the vertical migratory rhythms of benthic microalgae. A pulse amplitude fluorometer, an instrument which does not require physical contact with the sample, was used, thus allowing successive measurements to be taken on the same sample without causing any type of disturbance to the sediment structure. The basis of the method is the possibility to detect changes in the Chl a concentration near the sediment surface caused by the vertical movement of the microalgae. This requires the verification of two conditions: the possibility to follow changes in the sediment Chl a content from fluorescence intensity, and a sediment photic depth smaller than the vertical distances covered by the moving microalgae. Both conditions were experimentally verified in intertidal muddy sediments of the Tagus estuary, Portugal. In vivo fluorescence was shown to vary linearly with the sediment Chl a content, and the sediment photic depth was estimated to reach 0.27 mm, a value clearly smaller than the reported depths for microalgal migrations. Sediment samples kept under in situ conditions exhibited large hourly Variations (over 400%) in the Chl a fluorescence intensity, which were closely synchronized with the daytime periods of emersion. The rhythmic fluctuations in Chl a fluorescence were confirmed further to represent microalgal migration by (1) its endogenous nature (fluorescence continued to follow diurnal and tidal cycles after removal of environmental stimuli), (2) its dependence on the vertical distribution of the microalgal population within the sediment (vertically homogenized samples failed to display fluorescence variations), and (3) the lack of significant temperature and light effects on the fluorescence emission under in situ conditions (tested in three species representative of the main groups found in the studied microphytobenthic communities—the diatom Phaeodactylum tricornutum (Böhlin), the cyanobacterium Spirulina maxima (Setch. et Gard.), and the euglenophyte Euglena granulata (Klebs) Lemm. ). The results obtained indicate that, in spite of the potential concurrent effects of factors other than the Chl a concentration on the fluorescence intensity, in vivo Chl a fluorescence can be used to trace nondestructively the migratory behavior of benthic microalgae.
CeO2-Supported Pt Catalysts Derived from MOFs by Two Pyrolysis Strategies to Improve the Oxygen Activation Ability

Functional metal organic framework (MOF) derivatives have attracted tremendous attention as promising catalysts for various reactions. The thermal decomposition strategies have a vital effect on the structures and physicochemical properties of functional MOF derivatives. Nevertheless, what effect does the pyrolysis strategy have on MOF derivatives need further study. In this work, one-step (under dry air) and two-step (first under N2 and then dry air) pyrolysis are chosen to prepare the functional ceria-based MOF derivatives with novel hierarchical pore structure. In comparison with the derivatives prepared by one-step pyrolysis, the two-step pyrolysis composites exhibit better catalytic activity for toluene oxidation due to the higher contents of surface absorbed oxygen species and surface oxygen vacancies. The reusability and durability test demonstrates perfect stability of such functional MOF derivatives. The in-situ UV Raman reveals that two-step strategy is favorable for enhancing the gaseous oxygen activation ability of the functional MOF derivatives. Those findings may instruct the synthesis of functional MOF derivatives via different pyrolysis strategies as well as afford a further understanding of the crucial role of oxygen vacancies.
Targeted Delivery of Iron Oxide Nanoparticle-Loaded Human Embryonic Stem Cell-Derived Spherical Neural Masses for Treating Intracerebral Hemorrhage

This study evaluated the potential of iron oxide nanoparticle-loaded human embryonic stem cell (ESC)-derived spherical neural masses (SNMs) to improve the transportation of stem cells to the brain, ameliorate brain damage from intracerebral hemorrhage (ICH), and recover the functional status after ICH under an external magnetic field of a magnet attached to a helmet. At 24 h after induction of ICH, rats were randomly separated into three experimental groups: ICH with injection of phosphate-buffered saline (PBS group), ICH with intravenous injection of magnetosome-like ferrimagnetic iron oxide nanocubes (FION)-labeled SNMs (SNMs* group), and ICH with intravenous injection of FION-labeled SNMs followed by three days of external magnetic field exposure for targeted delivery by a magnet-embedded helmet (SNMs*+Helmet group). On day 3 after ICH induction, an increased Prussian blue-stained area and decreased swelling volume were observed in the SNMs*+Helmet group compared with that of the other groups. A significantly decreased recruitment of macrophages and neutrophils and a downregulation of pro-inflammatory cytokines followed by improved neurological function three days after ICH were observed in the SNMs*+Helmet group. Hemispheric atrophy at six weeks after ICH was significantly decreased in the SNMs*+Helmet group compared with that of the PBS group. In conclusion, we have developed a targeted delivery system using FION tagged to stem cells and a magnet-embedded helmet. The targeted delivery of SNMs might have the potential for developing novel therapeutic strategies for ICH.
Neuroinflammation in Aged Brain: Impact of the Oral Administration of Ellagic Acid Microdispersion

The immune system and the central nervous system message each other to preserving central homeostasis. Both systems undergo changes during aging that determine central age-related defects. Ellagic acid (EA) is a natural product which is beneficial in both peripheral and central diseases, including aging. We analyzed the impact of the oral administration of a new oral ellagic acid micro-dispersion (EAm), that largely increased the EA solubility, in young and old mice. Oral EAm did not modify animal weight and behavioral skills in young and old mice, but significantly recovered changes in “ex-vivo, in vitro” parameters in old animals. Cortical noradrenaline exocytosis decreased in aged mice. EAm administration did not modify noradrenaline overflow in young animals, but recovered it in old mice. Furthermore, GFAP staining was increased in the cortex of aged mice, while IBA-1 and CD45 immunopositivities were unchanged when compared to young ones. EAm treatment significantly reduced CD45 signal in both young and old cortical lysates; it diminished GFAP immunopositivity in young mice, but failed to affect IBA-1 expression in both young and old animals. Finally, EAm treatment significantly reduced IL1beta expression in old mice. These results suggest that EAm is beneficial to aging and represents a nutraceutical ingredient for elders.
Potential Application of Whole Body Vibration Exercise for Improving the Clinical Conditions of COVID-19 Infected Individuals: A Narrative Review from the World Association of Vibration Exercise Experts (WAVex) Panel

COVID-19 is a highly infectious respiratory disease which leads to several clinical conditions related to the dysfunction of the respiratory system along with other physical and psychological complaints. Severely affected patients are referred to intensive care units (ICUs), limiting their possibilities for physical exercise. Whole body vibration (WBV) exercise is a non-invasive, physical therapy, that has been suggested as part of the procedures involved with pulmonary rehabilitation, even in ICU settings. Therefore, in the current review, the World Association of Vibration Exercise Experts (WAVEX) reviewed the potential of WBV exercise as a useful and safe intervention for the management of infected individuals with COVID-19 by mitigating the inactivity-related declines in physical condition and reducing the time in ICU. Recommendations regarding the reduction of fatigue and the risk of dyspnea, the improvement of the inflammatory and redox status favoring cellular homeostasis and the overall improvement in the quality of life are provided. Finally, practical applications for the use of this paradigm leading to a better prognosis in bed bound and ICU-bound subjects is proposed.
Population Dynamics of Hyalomma dromedarii on Camels in the United Arab Emirates

Hyalomma dromedarii is the most important tick species infesting camels in the Middle East. So far, there are no studies on the population dynamics of H. dromedarii ticks on camels in the United Arab Emirates (UAE). Thus, the current study was performed: (1) to assess H. dromedarii population dynamics under common camel breeding and management practices in the study area, (2) to evaluate H. dromedarii life stage changes and sex ratio over time, and (3) to measure parasitological indicators of H. dromedarii infestation. We conducted monthly on-site tick visual counts and collection from camels in Al Ain, UAE, over 12 months. Our results show that the infestation prevalence was very high during the whole study period, with a mean of 94.33%. The maximum infestation intensity occurred in June, while the minimum occurred in January. Overall, H. dromedarii ticks were found on camels during the entire year in spite of monthly applications of an acaricide. This study reveals that H. dromedarii has a very high prevalence and continuous presence on camels in the UAE regardless of the weather fluctuations and acaricide applications and showed the need for an effective control strategy.
Propagation Protocol for Bareroot Silver Buffaloberry ( Shepherdia argentea )

Silver buffaloberry (Shepherdia argentea (Pursh) Nutt. [Elaeagnaceae]) can be successfully produced as a 2+0 bareroot nursery stocktype from seeds. In Colorado, we sow seeds in late fall, typically the first to second week of October. Plants will emerge by the second week of May. We apply granular ammonium sulfate (21N:0P2O5:0K2O:24SO4) during both growing seasons to meet our target specifications. At our nursery, buffaloberry is one of the first crops to be harvested; we usually start around the first of November. Once harvested, plants are graded (minimum stem diameter at the root collar of 5 mm [3/16 in] and minimum height of 46 cm [18 in]), packed into wax-coated cardboard boxes, and stored in a cooler until shipment the following spring. Silver buffaloberry is a species suitable for windbreaks and wildlife habitat, with opportunities for ornamental and landscape uses as well.
Visiting the methodological aspects of flooding experiments: Quantitative evidence from agricultural and ecophysiological studies

Plant responses to flooding have been studied and reviewed extensively. However, the differences among the experimental procedures used to apply the flood that lead to such responses have never been explored. In this work, a database of 132 articles was created to quantify important methodological aspects of flooding experiments in crop and non-crop species for the first time as well as to look for thematic gaps in our knowledge on flooding research. Results showed that the flood experiments were conducted differently for crop and non-crop species, with two main distinctions: the duration of the flood and the consideration of competition among plants. For crop species, experimental flooding had a short duration of 16 days (ranging from 8 to 28 days for the 25th and 75th percentiles), while for non-crop species, flooding was quite longer, nearly 45 days (ranging from 28 to 61.5 days). Also, 53 % of the examined experiments in crop species considered competition among plants in their experimental protocol, while only 20 % did so for non-crop species. Regarding the topics least investigated within this area, in terms of both crop and non-crop species, future investigation should focus on the effects of flooding on reproductive traits, mineral nutrition and the nitrogen fixation of plants. These results are discussed, along with their implications in terms of defining crucial aspects of the methodology of flooding experiments.
Genetic and Phenotypic Parameters for a Profit Function and Selection Method for Optimizing Profit in Dairy Cattle

Abstract Genetic and phenotypic relationships were estimated on a profit function for 933 Holstein cows. Methods of selection among cows were investigated for profit per day of herdlife. The profit function included production, reproduction, and body weight. Heritability for profit/day during first lactation was . 50 ± . 12 compared to . 28 ± . 10 for milk/day in the first lactation. Correlations (genetic, phenotypic) between first lactation and lifetime records per day of herdlife were (.93, .74) for milk production and (.79, .65) for profit. Correlations between milk/day-first and profit/day-life were (.85, .55). Correlations for total lifetime production and profit were (.95, .97) and per day of herdlife were (.94, .87). Herdlife compared to lifetime traits had larger correlations with profit/day than yield/day (.64 versus .40, .69 versus .48) indicating the profit function contained important factors related to herdlife besides lactation performance. Correlations between age at first calving with total lifetime production and profit were negative (−.15 to −.32, −.16 to −.07), suggesting an increase in these traits can be expected in selection for younger age at first calving. Genetic gain expected in profit/day of life from selection on profit/day-first lactation was 24% more efficient than milk/day-first. A simplified profit function may be effective for increasing profitability in dairy production by selection.
Evaluation of Psychological Stress Parameters in Coronary Patients by Three Different Questionnaires as Pre-Requisite for Comprehensive Rehabilitation

Background: Negative psychological conditions are common in patients with cardiovascular diseases. Although depression has been scrutinized over the years in these patients, only recently has anxiety emerged as another important risk factor. The purpose of this study was to compare the parameters of psychological stress in a population of coronary patients with and without myocardial revascularization procedures and to analyze lifestyle and socio-economic contributors to the state of health of these patients before inclusion in a comprehensive individualized rehabilitation program. Methods: This study included 500 patients with coronary artery disease (CAD) in stable condition divided in 2 groups: 200 patients who underwent coronary artery bypass grafting (CABG) or percutaneous transluminal coronary angioplasty (PTCA) (Group 1) and 300 patients without myocardial revascularization (Group 2) with stable angina or thrombolyzed myocardial infarction. The protocol included screening for anxiety/depression after procedure using three different scales: Duke Anxiety-Depression Scale, Hospital Anxiety and Depression Scale (HADS) and the Type D Personality Scale (DS-14) scale that evaluates negative affectivity (NA) and social inhibition (SI). Results: Significant differences between groups were observed for HAD-A (9.1 ± 4.18 for Group 1 vs. 7.8 ± 4.03 for Group 2, p = 0.002) and DUKE scores (30.2 ± 12.25 for Group 1 vs. 22.7 ± 12.13 for Group 2, p < 0.001). HAD-A scores (p = 0.01) and DUKE scores (p = 0.04) were significantly higher in patients who underwent PTCA vs. CABG. CAD patients without myocardial revascularization (Group 2, n = 300) presented anxiety in proportion of 72.3% (n = 217) out of which 10.7% (n = 32) had severe anxiety, and 180 patients had depression (a proportion of 60%) out of which 1.3% (n = 4) presented severe depression. The correlation between the presence of type 2 diabetes mellitus (T2DM) and type D personality in revascularized patients (n = 200) was significant (Chi2 test, p = 0.010). By applying multinomial regression according to the Cox and Snell R-square model and multivariate linear regression by the Enter method, we demonstrated that male gender, age and marital status proved significant predictors for psychological stress in our study population. Conclusions: The results obtained in this study provide a framework for monitoring anxiety, depression and type D personality in coronary patients before inclusion in comprehensive rehabilitation programs. Behavioral and psychological stress responses in patients with CAD significantly correlate with risk factors, and could influence the evolution of the disease. Moreover, other factors like gender, income and marital status also seem to play a decisive role. Evaluation of psychological stress parameters contributes to a better individualization at the start of these programs, because it allows adjusting of all potential factors that may influence positive outcomes.