Miracle-dz/UniFAR-FTUs huggingface dataset:
RUNNING HEAD: NOVEL COGNITIVE TEST FOR PRECLINICAL ALZHEIMER’S DISEASE A Novel Cognitive Stress Test for the Detection of Preclinical Alzheimer’s Disease: Discriminative Properties and Relation to Amyloid Load

OBJECTIVE : To examine the utility of a novel “cognitive stress test” to detect subtle cognitive impairments and amyloid load within the brains of neuropsychologically normal community-dwelling elders. DESIGN: Participants diagnosed as cognitively normal (CN), subjective memory impairment (SMI), mild cognitive impairment (MCI) and pre-clinical mild cognitive impairment (PreMCI) were administered the LASSI-L, a sensitive test of proactive semantic interference (PSI), retroactive semantic interference and uniquely, the ability to recover from the effects of PSI. SETTING: Ninety-three subjects (31 males and 62 females) were recruited from three academic institutions in a research consortium. A subset of these individuals underwent F-18 Florbetapir PET scanning. MEASURES: Relative percentages of impairment for each diagnostic group on the LASSI-L were calculated by chi-square and Fisher’s Exact Test. Spearman’s rho was employed to examine associations between amyloid load, and different cognitive measures. RESULTS: LASSI-L deficits were identified among 89% of those with MCI, 47% with PreMCI, 33% with SMI and 13% of those classified as CN. CN subjects had no difficulties with recovery from PSI while SMI, preMCI and MCI participants evidenced deficits in recovery from PSI effects. Among a subgroup of participants with normal scores on traditional neuropsychological tests, the strong associations were between the failure to recover from the effects of PSI and amyloid load in the brain. CONCLUSIONS: Failure to recover or compensate for the effects of PSI on the LASSI-L distinguishes the LASSI-L from other widely used neuropsychological tests and appears to be sensitive to subtle cognitive impairments and increasing amyloid load. A standard uptake value ratio (SUVR) computed, relative the cerebellum, for the following composite of cortical regions: frontal, lateral temporal, parietal, anterior cingulate, posterior cingulate and precuneus. The choice of regions was based on neocortical regions where amyloid deposition occurs early and which are particularly vulnerable neurodegeneration associated with AD. 10,22 The regions were chosen to be sensitive to amyloid accumulation in
WHAT İS EFFECTİVENESS ON THE HEART OF DRUGS USED İN ALZHEİMER’S DİSEASE?

Objective: The aim of this study was to retrospectively determine the Emergency or Cardiology department admission rates with cardiac complaints of the patients with Alzheimer’s disease(AD) and establish whether these rates changed between the patients who used acetylcholinesterase inhibitors (AchEI) and those who did not. Materials and Methods: This single-centered retrospective study included 605 patients who were diagnosed with AD between January 2010 and 2018. The patient group was separated to two subgroups according to the use of AChEIs. Results: Comparison of these two subgroups in terms of baseline demographic and clinical characteristics demonstrated that there was no significant difference between them(p>0.05). When these two groups were compared in terms of the ratio of myocardial infarction, angina pectoris, bradycardia, hypotension or serious arrhythmia identicated that there was no significant difference (respectively, p=0.96, p=0.87, p=0.12, p=0.23, p=0.17). Besides, there was no significant difference between two groups in terms of the ratio of cardiac causes of death,too(p=0.21). Conclusion: In this study, it was shown that there was no significant difference between the ratio of cardiac death and Cardiology and/ or Emergency department admission with cardiac complaints between patients with AD using AChEIs and those not using.
Establishing the relationship of monitoring and review with project success of small and medium contractors in South Africa

—Monitoring and review are very essential management tools for ensuring that project objectives in construction are fully accomplished and that the project remains on track. However, it appears that little research has been conducted in South Africa, on the relationship of monitoring and review with project success of contractors especially within small and medium contractors (SMEs). Hence, the current study aims to empirically establish this relationship at project level of construction SMEs. To achieve this aim, a structured questionnaire was used to collect data from SMEs who were conveniently sampled in the Gauteng province of South Africa. The data was analysed using the Statistical Package for the Social Sciences (SPSS) version 23, computing inferential statistics. Empirical findings revealed that project success was positively influenced by monitoring and review. This was an indication that project monitoring and review in construction are important risk management practices that enhance project management decision making and hence influence project success. The findings recommend contractors to fully implement monitoring as part of their project risk management activities.
PGPM_A_249649 151..156

*These authors contributed equally to this work Background: Hirschsprung disease (HSCR) is a congenital disease that arises from defective intestinal neural system. LncRNA HOTTIP is a critical gene in various diseases, including HSCR. No epidemiological studies have explored the correlation between lncRNA HOTTIP single nucleotide polymorphisms (SNPs) and HSCR risk. We here lead as a pioneer to explore whether SNPs in lncRNA HOTTIP impact the risk of HSCR and HSCR subtypes in an unrelated Chinese population. Methods: We used the TaqMan method to genotype rs3807598 C>G of the lncRNA HOTTIP gene using 1470 HSCR cases and 1473 healthy controls. Of them, 1441 cases and 1434 controls were successfully genotyped. We adopted odds ratios (ORs) and 95% confidence intervals (CIs) to quantify the relationship. Results: We got an unexpected outcome that lncRNA HOTTIP SNP rs3807598 C>G could not modify the risk of HSCR (CG vs. CC: adjusted OR=0.89, 95% CI=0.74–1.07; GG vs. CC: adjusted OR=1.10, 95% CI=0.89–1.37; GG/CG vs CC: adjusted OR=0.95, 95% CI=0.80–1.13; and GG vs. CC/CG: adjusted OR=1.19, 95% CI=0.99–1.43). What’s more, risk effect of lncRNA HOTTIP rs3807598 C>G is still not obvious in stratification analysis by HSCR subtype. Conclusion: Our studies did not provide statistical evidence of a correlation between lncRNA HOTTIP SNP rs3807598 C>G and susceptibility of HSCR in the Chinese population that is being studied. Further validation study with a larger sample size covering multiethnic groups is warranted.
MORBIDITY AND MORTALITY OF TOXIC EPIDERMAL NECROLYSIS AND STEVEN JONSON SYNDROME TEN/SJS AMONG SUDANESE PATIENTS

Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN) and their overlap are rare severe cutaneous adverse drug reactions with a fatal potentiality. They are characterized by epidermal necrosis which causes erosions of the mucous membranes, extensive detachment of the epidermis, and severe constitutional symptoms. Drugs are the major causes of SJS\TEN. The types of the drugs depend on the prevalent diseases in the country and the protocols of management in that country. This is a Retrospective hospital based study, was done to detect the morbidity and mortality of SJS / TEN and their overlap, among Sudanese patients admitted to Khartoum Dermatology and Venereology Hospital from April 2004 to April 2014. In our study 150 patients were enrolled, the main age distribution was between 21 - 40 years in (48.7%),
The Boundary layer over a flat plate

The properties of the boundary-layer over a at plate have been investigated analytically, experi- mentally and numerically employing XFOIL. With the theory from Blasius and von K�arm�an, the boundary-layer properties over an in�nitesimally thin at plate have been investigated analytically. A �nite thickness plate, designed to behave aerodynamically as a at plate, with a Hermite polynomial leading edge and a trailing edge corresponding to the last 70% of a NACA 4-series airfoil section, has been analyzed with XFOIL and has been investigated mounted at zero angle of attack in the Silent Wind Tunnel of the University of Twente. Initial measurements have been performed to obtain the drag force and velocity pro�le. The drag force was measured with load cells and the velocity pro�le was determined with a Pitot tube and a single-wire Hot Wire probe (55P11) at various Reynolds numbers. The measurements indicate a delayed transition from laminar to turbulent ow at a Reynolds number around Recrit=3�106 instead of the expected Recrit=5�105. Leading-edge turbulence strips were also applied in order to investigate the drag force and the transitional boundary layer. The found delayed transition is unfavourable for further research on the in uence of the surface roughness on transition because of the maximum velocity achievable in the Silent Wind Tunnel. Since the turbulence level of the Silent Wind Tunnel is relatively low (approximately 0.25%), other possibil- ities have been investigated on the cause of the delayed transition. Results of numerical simulations using XFOIL indicated that a small change in the streamwise pressure gradient can delay transition substantially. Therefore, additional measurements have been performed on the streamwise pressure gradient in the Silent Wind Tunnel. These results indicate an existing streamwise pressure gradient in the test section of the Silent Wind Tunnel which is ampli�ed when the plate is installed in the wind tunnel and may have been the cause of the delayed transition.
triceps, or both responses improve the success rate of the interscalene catheter surgical block compared with the biceps response

Results: Demographic and surgical data were similar in both groups. The success rate was 98.6% in the DT-group versus 92.5% in the B-group (p<0.05). Supplementary analgesics during handling of the posterior part of the shoulder capsule were needed in 2 DT-group patients and in 7 B-group patients. In the B-group, 3 patients had an incomplete radial nerve distribution anesthesia, causing the necessity of general anesthesia. One patient in the B-group had an isolated incomplete posterior block extension of the supraclavicular nerve. No acute (CNS-intoxication, cardiac toxicity) or late complications (infection, neuropathy after 30 days) were observed in both groups. Conclusion: The elicitation of deltoid and/or triceps twitches was associated with a higher success rate compared to biceps response when performing an intrascalene catheter.
Nutritional strategies to alleviate the effect of heat stress on Iberian pigs

High ambient temperature exposure can cause important consequences on animals’ health and production. As pigs have unfunctional sweat glands, they are more sensible to heat stress than other animals. For this reason, this experiment was held in order to study a nutritional strategy to alleviate the effect of heat stress in pigs. The nutritional strategy was to replace 5% of starch by 5% of high oleic sunflower oil in the diet as fat is an important source of energy and lead to a lesser heat increment than carbohydrates and protein. Therefore, a total of seventy-two castrated males crossed (50% Iberian – 50% Duroc) Iberian pigs weighing an average of 51.1 ± 0.75 Kg were exposed to high ambient temperature of (30 – 32C) during 5 hours of the day and during the other hours, the temperature was maintained at a minimum of 25°C. The pigs were distributed in three rooms at the rate of four pens per room and six animals per pen. Two treatments were applied based in two different diet composition: control diet (control) and high fat diet (alternative). In addition, two forms of feeding were used. Half of the animals were fed ad-libitum and the other half restricted. Samples for the analysis of hemogram and biochemical were taken at the beginning and at the end of the study and an analysis of meat and carcass quality was performed after slaughter. Moreover, performance (feed intake, body weight) was regularly assessed and pigs’ behavior observed daily. During the experimental period, the feed intake was reduced while there was no difference on the average daily gain, consequently feed conversion ratio was lower in the alternative diet (high fat content) than in the control diet. LDL levels, the bad cholesterol, did not show any difference between the two diets showing that increasing the diet content in fat did not show bad consequences on serum lipid content in pigs. Additionally, feeding the alternative diet resulted in a higher dressing percentage and oleic content in fat. Moreover, the lying and excreting behavior in addition to the social interactions were affected by the temperature and differed between treatments. In conclusion, replacing the starch by fat during high ambient temperature conditions improved the feed efficiency, carcass characteristics and the final product obtained was more attractive to the consumers due to the higher content in oleic acid.
OPTH_A_261783 2043..2050

Department of Ophthalmology, Faculty of Medicine, Fayoum University, Al Fayoum, Egypt Purpose: To compare the outcomes of anterior lamellar recession (ALR) versus posterior lamellar tarsal rotation (PLTR) procedure for the repair of lower eyelid trachomatous trichiasis (TT). Design: Prospective randomized comparative trial. Methods: Study Population and Interventions: Patients with lower eyelid TT were enrolled. Patients with a history of lower lid surgery, marked horizontal lid laxity, another evident cause for the trichiasis, and those under 18 years were excluded. Participants were randomized to either PLTR or ALR. The sequence was computer-generated by an independent statistician, and the allocation sequence was concealed in sealed opaque envelops. Patients were evaluated at 1 week and 1, 3, 6, and 12 months. Main Outcome Measures: postoperative trachomatous trichiasis (PTT) and cosmetic satisfaction. Results: A total of 60 patients were randomly assigned with 30 patients in each group. Two (3.3%) participants in PLTR group did not follow up and were excluded from the analysis. At 1, 3, and 6 months, PTT was significantly more frequent in the PLTR group than the ALR group (14.3% vs 0%; p= 0.048, 25% vs 0%; p= 0.004, 35.7% vs 10%; p= 0.019, respectively). In the ALR group, 6 patients (20%) had PTT at their 12-month follow-up visit compared with 15 patients (53.6%) in the PLTR group (P = 0.008) with absolute risk reduction of 33.6% (95% (CI= 9% −58%)). Cosmetic dissatisfaction was significantly more frequent in the ALR group at the initial follow-up visits compared to the PLTR group. However, this difference was no longer significant at 6 and 12 months follow-up. Conclusion: These data provide strong evidence that ALR is more effective in correction of lower eyelid trachomatous trichiasis with acceptable cosmesis compared with PLTR.
Localized waves in elastic plates with perturbed honeycomb arrays of constraints

In this paper, we study wave propagation in elastic plates incorporating honeycomb arrays of rigid pins. In particular, we demonstrate that topologically non-trivial band-gaps are obtained by perturbing the honeycomb arrays of pins such that the ratio between the lattice spacing and the distance of pins is less than 3; conversely, a larger ratio would lead to the appearance of trivial stop-bands. For this purpose, we investigate band inversion of modes and calculate the valley Chern numbers associated with the dispersion surfaces near the band opening, since the present problem has analogies with the quantum valley Hall effect. In addition, we determine localized eigenmodes in strips, repeating periodically in one direction, that are subdivided into a topological and a trivial section. Finally, the outcomes of the dispersion analysis are corroborated by numerical simulations, where a time-harmonic point source is applied to a plate with finite arrays of rigid pins to create localized waves immune to backscattering. This article is part of the theme issue ‘Wave generation and transmission in multi-scale complex media and structured metamaterials (part 1)’.
Observing ozone chemistry in an occupied residence.

1 Outdoor ozone transported indoors initiates oxidative chemistry, forming volatile organic 2 products. The influence of ozone chemistry on indoor air composition has not been directly 3 quantified in normally occupied residences. Here, we explore indoor ozone chemistry in a house 4 in California with two adult inhabitants. We utilize space- and time-resolved measurements of 5 ozone and volatile organic compounds (VOCs) acquired over an eight-week summer campaign. 6 Despite overall low indoor ozone concentrations (mean value of 4.3 ppb) and a relatively low 7 indoor ozone decay constant (1.3 h -1 ), we identified multiple VOCs exhibiting clear contributions 8 from ozone-initiated chemistry indoors. These chemicals include 6-methyl-5-hepten-2-one (6- 9 MHO), 4-oxopentanal (4-OPA), nonenal, and C8-C12 saturated aldehydes, which are among the 10 commonly reported products from laboratory studies of ozone interactions with indoor surfaces 11 and with human skin lipids. These VOCs together accounted for ≥ 12% molecular yield with 12 respect to house-wide consumed ozone, with the highest net product yields for nonanal ( ≥ 13 3.5%), followed by 6-MHO (2.7%) and 4-OPA (2.6%). Although 6-MHO and 4-OPA are 14 prominent ozonolysis products of skin lipids (specifically squalene), ozone reaction with the 15 body envelopes of the two occupants in this house are insufficient to explain the observed yields. 16 Relatedly, we observed that ozone-driven chemistry continued to produce 6-MHO and 4-OPA 17 even after the occupants had been away from the house for 5 days. These observations provide 18 evidence that skin lipids transferred to indoor surfaces made substantial contributions to ozone reactivity in the studied house.
MIP-3 (cid:1) neutralizing monoclonal antibody protects against TNBS-induced colonic injury and inﬂammation in mice

MIP-3 (cid:1) neutralizing monoclonal antibody protects against TNBS-induced colonic injury and inﬂammation in mice. Am Physiol Gastrointest Liver Physiol G1263–G1271, 2007. characteristic feature of human inﬂammatory bowel disease, particularly Crohn’s disease, is the presence of activated CD4 (cid:2) T cells. Recently, we have shown that colonic epithelial cell production of macrophage inﬂammatory protein (MIP)-3 (cid:1) , a CD4 T cell-directed chemokine, is elevated in inﬂammatory bowel disease. However, the functional relevance of MIP-3 (cid:1) production during intestinal inﬂammation is poorly understood. The aim of this study was to determine whether MIP-3 (cid:1) production is increased during murine 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis and to examine the effect of anti-MIP-3 (cid:1) neutralizing monoclonal antibody administration in this model. We found that the administration of TNBS signiﬁcantly increased colonic MIP-3 (cid:1) protein levels in Balb/c mice. Consistent with this, a marked increase in the number of CCR6-bearing lamina propria CD4 (cid:2) and CD8 (cid:2) T cells was also observed in TNBS-treated animals. Treatment of mice with an anti-MIP-3 (cid:1) neutralizing monoclonal antibody signiﬁcantly reduced TNBS-mediated increases in colonic weight-to-length ratio, mucosal ulceration, histological damage, and myeloperoxidase activity. TNBS-mediated increases in the number of CCR6-bearing lamina propria T cells were also substantially reduced by anti-MIP-3 (cid:1) neutralizing monoclonal antibody treatment. Taken together, our ﬁndings indicate that blockade of MIP-3 (cid:1) bioactivity can signiﬁcantly reduce TNBS-mediated colonic injury and T cell recruitment, suggesting a role for this chemokine in the pathophysiology of intestinal inﬂammation.
Kobe University Repository : Kernel タイトル Tit le S 100 A 12 facilitates osteoclast different iat ion from human monocytes 著者

Osteoclasts play a critical role not only in bone homeostasis but also in inflammatory osteolysis, such as that occurring in inflammatory arthritis and systemic inflammation. In both inflammation conditions, inflammatory cytokines like Interleukin (IL)-1, IL-6 and tumor necrosis factor (TNF)-α induce RANKL expression in osteoblasts, but the roles of these cytokines in osteoclast activation remain unclear. S100A12, an S100 family member, is a low-molecular-weight calcium-binding protein. Although it has a pro-inflammatory role, its effects on osteoclast differentiation have been unclear. Here we examined the direct effects of S100A12 on human osteoclasts in vitro. S100A12 facilitated osteoclast formation in the presence of RANKL, as judged by the cells’ morphology and elevated expression of osteoclast-related molecules, including NFATc1, ACP5, CALCR, and ITGβ3. In addition, S100A12 administration markedly enhanced the osteoclasts’ bone resorption ability, consistent with their increased expression levels of CTSK and CA2. Blocking RAGE and TLR4 cancelled the effects of S100A12. Our results indicate that S100A12 is a potential therapeutic target for inflammatory osteolysis.
Lyn/PI3K Module and Promoted by SHIP1 and TLR4 Is Negatively Regulated by a Activation of Murine Macrophages via TLR2

Src family kinases are involved in a plethora of aspects of cellular signaling. We demonstrate in this study that the Src family kinase Lyn negatively regulates TLR signaling in murine bone marrow-derived macrophages (BMM F s) and in vivo. LPS-stimulated Lyn 2 / 2 BMM F s produced signiﬁcantly more IL-6, TNF- a , and IFN- a / b compared with wild type (WT) BMM F s, suggesting that Lyn is able to control both MyD88- and TRIF-dependent signaling pathways downstream of TLR4. CD14 was not involved in this type of regulation. Moreover, Lyn attenuated proinﬂammatory cytokine production in BMM F s in response to the TLR2 ligand FSL-1, but not to ligands for TLR3 (dsRNA) or TLR9 (CpG 1668). In agreement with these in vitro experiments, Lyn-deﬁcient mice produced higher amounts of proinﬂammatory cytokines than did WT mice after i. v. injection of LPS or FSL-1. Although Lyn clearly acted as a negative regulator downstream of TLR4 and TLR2, it did not, different from what was proposed previously, prevent the induction of LPS tolerance. Stimulation with a low dose of LPS resulted in reduced production of proinﬂammatory cytokines after subsequent stimulation with a high dose of LPS in both WT and Lyn 2 / 2 BMM F s, as well as in vivo. Mechanis-tically, Lyn interacted with PI3K; in correlation, PI3K inhibition resulted in increased LPS-triggered cytokine production. In this line, SHIP1 2 / 2 BMM F s, exerting enhanced PI3K-pathway activation, produced fewer cytokines than did WT BMM F s. The data suggest that the Lyn-mediated negative regulation of TLR signaling proceeds, at least
A new Large Magellanic Cloud K -band distance from precision measurements of nearby red clump stars

High-precision ( σ mag < 0 . 01) new JHK observations of 226 of the brightest and nearest red clump stars in the solar neighbourhood are used to determine distance moduli for the Large Magellanic Cloud (LMC). The resulting K - and H -band values of 18.47 ± 0.02 and 18.49 ± 0.06 imply that any correction to the K -band Cepheid PL relation due to metallicity differences between Cepheids in the LMC and the solar neighbourhood must be quite small.