Miracle-dz/UniFAR-FTUs huggingface dataset:
Quality monitoring of resuscitative endovascular balloon occlusion of the aorta using cumulative sum analysis

Purpose: Resuscitative endovascular balloon occlusion of the aorta (REBOA) is a state-of-the-art lifesaving procedure. However, due to its high mortality and morbidity, including ischemia and reperfusion injury, well-trained medical staff and effective systems are needed. This study was conducted to investigate the learning curve for REBOA. Methods: To monitor this learning curve, we used cumulative sum (CUSUM) analysis and graphs of mortality and aortic occlusion time within 60, 90, and 120 minutes for consecutive patients. The procedures performed between July 2017 and June 2021 were divided into pre-trauma center (pre-TC; July 2017–February 2020) and TC (February 2020–June 2021) periods. Results: REBOA was performed for 31 consecutive patients with trauma. The pre-TC (n=12) and TC (n=19) periods did not differ significantly with regard to Injury Severity Score, age, injury mechanism, initial systolic blood pressure, prehospital cardiopulmonary resuscitation (CPR), or CPR in the emergency department. At the 17th consecutive patient during the TC period, CUSUM failure graphs for mortality and aortic occlusion time exhibited a downward inflection, indicating an improvement in performance. Conclusions: The mortality and aortic occlusion time of REBOA improved, and these parameters can be monitored using CUSUM analysis at the hospital level.
Eigenvalues associated with prolate spheroidal wave functions of zero order

Presented here are tables of values of X n and λ n , quantities defined by the eigenvalue problems $(1-x^2)\psi_n\Prime - 2x\psi_n\prime + (x_n - c^2x^2)\psi_n =0$ and $\lambda-n \psi_n (x) = \int_{-1}^1 {sin c(x-y)\over \pi(x-y)} \psi-n(y) dy. $ In addition, some approximations for these quantities are given and evaluated.
Short-Wavelength Aggregation-Induced Emission Photosensitizers for Solid Tumor Therapy: Enhanced with White-Light Fiber Optic

Background White-light photodynamic therapy (wPDT) has been used in the treatment of cancer due to its convenience, effectiveness and less painful. However, the limited penetration of white-light into the tissues leads to a reduced effectiveness of solid tumor treatment. Methods Two short-wavelength aggregation-induced emission (AIE) nanoparticles were prepared, PyTPA@PEG and TB@PEG, which have excitation wavelengths of 440 nm and 524 nm, respectively. They were characterized by UV, fluorescence, particle size and TEM. The ability of nanoparticles to produce reactive oxygen species (ROS) and kill cancer cells under different conditions was investigated in vitro, including white-light, after white-light penetrating the skin, laser. A white-light fiber for intra-tumor irradiation was customized. Finally, induced tumor elimination with fiber-mediated wPDT was confirmed in vivo. Results In vitro, both PyTPA@PEG and TB@PEG are more efficient in the production ROS when exposed to white-light compared to laser. However, wPDT also has a fatal flaw in that its level of ROS production after penetrating the skin is reduced to 20–40% of the original level. To this end, we have customized a white-light fiber for intra-tumor irradiation. In vivo, the fiber-mediated wPDT significantly induces tumor elimination with maximized therapeutic outcomes by irradiating the interior of the tumor. In addition, wPDT also has the advantage that its light source can be adapted to a wide range of photosensitizers (wavelength range 400–700 nm), whereas a laser of single wavelength can only target a specific photosensitizer. Conclusion This method of using optical fiber to increase the tissue penetration of white light can greatly improve the therapeutic effect of AIE photosensitizers, which is needed for the treatment of large/deep tumors and holds great promise in cancer treatment.
Droplet contact angle behavior on a hybrid surface with hydrophobic and hydrophilic properties

A hybrid surface consisting of an array of hydrophobic and hydrophilic sites was designed and fabricated in an effort to better understand the effects of microscale surface features and chemistry on wettability. A model based on energy minimization was developed to design and predict the wettability of hybrid surfaces. Measured advancing, receding, and equilibrium contact angles fit the proposed model well. Experiments show that a higher degree of hydrophobicity results in higher contact angles and that contact angle hysteresis increases with decreasing micropillar spacing (b/a). Moreover, measured roll-off angle as an indicator of droplet shedding, decreases with b/a.
Two-Stage Short-Run ([Xbar], s) Control Charts

This article develops the theory that is needed to apply the two-stage short-run theory of control charting to ([Xbar], s) charts. It then uses this theory to derive the equations for calculating the factors required to determine two-stage short-run control limits for ([Xbar], s) charts. Also, equations to calculate conventional control chart constants for ([Xbar], s) charts are derived. Additionally, this article gives advantages of two-stage short-run ([Xbar], s) control charts.
Allowed transitions and intercombination lines in C III and C II

Systematic multiconfiguration Hartree-Fock results in the Breit-Pauli approximation are reported for the 2s2 1S0 → 2s2p 3P1 intercombination line in C III and the 2s22p2P-2s2p3 4P multiplet in C II. Length and velocity forms of the oscillator strengths of related allowed transitions are also reported. The latter are used as a check on accuracy along with term energy separation and spin-orbit splitting. The predicted transition rate of 103 ± 3 s−1 for the intercombination line in C III lies outside the experimental error bars whereas the decay rates for C II are near the lower experimental limits.
Impact of customer bounded rationality on on-demand service platforms

Abstract We consider an on-demand platform connecting independent agents and delay-sensitive boundedly rational customers. By adopting a queueing-game framework, we analyze the equilibrium joining behaviors of customers and agents, the platform’s optimal pricing strategy, and the resulting profit and social welfare. Moreover, we investigate how the bounded rationality level affects these results. We obtain the following main insights. First, when customers are irrational, the positive externality between the agents and the customers becomes weak. In other words, increasing the same number of agents attracts fewer boundedly rational customers than fully rational ones. Second, we distinguish two types of equilibria in terms of agent participation: one in which all or none of the agents participate and the other in which it is possible that a fraction of the agents may participate. We show that in the latter case, a social planner and a platform can easily align their goals since they are affected by the bounded rationality in the same direction. We attribute the insight to the interactions among the cross-side effect, bounded rationality, and the pooling effect embedded in a queueing system. Next, we characterize the platform’s optimal pricing decisions and prove that the increase in the bounded rationality level does not always lead to higher optimal prices and wages. Finally, we examine the agent side bounded rationality and the social welfare maximizing decisions in the extended models.
Lifting planar graphs to realize integral 3-polytopes and topics in pseudo- triangulations (Heben von planaren Graphen zur ganzzahligen Einbettung von 3-Polytopen und Themen über Pseudo-Triangulierungen)

Lifting planar embeddings with equilibrium stress is a well known method that dates back to the 19th century. We discuss the known theory about liftings and develop a framework that allows us to apply the lifting technique easily. In this thesis we apply the lifting method to different geometric problems. As a first application we show how to embed 3-polytopes with small integer coordinates. Our method improves the upper bound for the size of the largest coordinate from O(2 2 ) to O(2). A new generalized version of Tutte’s spring embedding assures that a planar 2d-embedding contains an equilibrium stress and is therefore liftable. We point out connections between the size of the integral embedding and the number of maximal spanning forests a planar graph can have. The second field of applications for the lifting technique are topics about pseudo-triangulations. Our main observation shows how to model regular triangulations as linear programs over the polytope of pointed pseudo-triangulations. We introduce an equivalent of the Delaunay triangulation for pointed pseudo-triangulations of simple polygons. Our approach is motivated by the paraboloid lifting of the Delaunay triangulation and the generalization of linear programs that compute the Delaunay triangulation in special cases. We also investigate the so-called canonical pointed pseudo-triangulation and study some of its geometric properties. Our observations lead to a new characterization of pointed pseudotriangulations as embeddings of minimal rigid graphs that can balance a given load with positive edge weights. The thesis contains also results on pseudo-triangulation problems that were not obtained with help of liftings. We show that a sequence of superpolynomial many convexifying flips exists that transform a lifted pseudotriangulation into a maximal locally convex surface. This is obtained by constructing a simple polygon that realizes an improving flip sequence of length n between two of its pointed pseudo-triangulation. Furthermore we show that (1) it is NP-hard to decide if a graph contains a pseudo-triangulation and (2) it is NP-hard to decide if a graph can be extended to a pseudo-triangulation with small vertex degree. Both decision problems are studied in different incarnations. We obtain a new and easier NP-completeness proof of the triangulation existence problem, one of the classic NP-complete triangulation problems.
Chimeric Antigen Receptor T-cell Therapies in Lymphoma Patients with Central Nervous System Involvement.

BACKGROUND AND OBJECTIVE CAR T-cell therapy has significantly improved the outcomes of patients with relapsed or refractory (R/R) B-cell non-Hodgkin lymphoma (B-NHL). However, most clinical trials excluded patients with central nervous system (CNS) involvement due to uncertain efficacy and safety. MATERIAL AND METHODS On January 1, 2022, we searched PubMed to identify all published literature associated with current commercial CAR T-cell therapies for B-NHL, including tisagenlecleucel (tisa-cel), axicabtagene ciloleucel (axi-cel), brexucabtagene autoleucel (brexu-cel), and lisocabtagene maraleucel (liso-cel). Studies that involved patients with either primary or secondary CNS lymphoma, and evaluated response rate, adverse events (AEs), or survival were included and summarized. RESULT Herein, we summarize the results of 11 studies qualified for our inclusion criteria, reporting 58 lymphoma patients with CNS Involvement with 44 evaluable for clinical response, 25 for immune effector cell-associated neurotoxicity syndrome (ICANS) and 48 for Cytokine release syndrome (CRS). Objective response was achieved in 62% (16/26) of patients, and CR was achieved in 52% (23/44) of patients. Forty-four percent (11/25) developed ICANS, and 35% (17/48) developed severe ICANS (grade≥3). CRS was reported in 63% (15/24) of patients, while severe CRS (grade≥3) was reported in 7% (3/42) of patients. CONCLUSION Based on our PubMed literature review, we conclude that CAR T-cell therapy may benefit patients with CNS lymphoma with promising response rates and acceptable AE. However, definite conclusions cannot be drawn until data with a larger sample size is available.
Histone lactylation driven by mROS-mediated glycolytic shift promotes hypoxic pulmonary hypertension

ABSTRACT Increased mitochondrial reactive oxygen species (mROS) and glycolysis have been established in pulmonary hypertension (PH). However, the effect of elevated mROS on glycolytic shift and how increased glycolysis promotes hypoxic pulmonary artery smooth muscle cell (PASMC) proliferation and vascular remodeling remain elusive. Here, we reported that hypoxia-induced mROS inhibit HIF-1α hydroxylation and further trigger PASMC glycolytic switch through the upregulated HIF-1α/PDK1&PDK2/p-PDH-E1α axis, which facilitates lactate accumulation and histone lactylation. Through H3K18la and HIF-1α ChIP–seq analysis, we found that the enhanced histone lactylation of HIF-1α targets, such as Bmp5, Trpc5, and Kit, promotes PASMC proliferation. Knockdown of Pdk1&2 blunts lactate production, histone lactylation marks, and PASMC proliferation. Moreover, pharmacological intervention with lactate dehydrogenase inhibitor diminishes histone lactylation and ameliorates PASMC proliferation and vascular remodeling in hypoxic PH rats. Taken together, this study provides proof of concept for anti-remodeling therapy through lactate manipulation.
Wronskian solutions of the constrained Kadomtsev–Petviashvili hierarchy

The integrable Kadomtsev–Petviashvili (KP) hierarchy is compatible with generalized k‐constraints of the type (Lk)−=∑i qi∂−1xri. A large class of solutions—among them solitons—can be represented by Wronskian determinants of functions satisfying a set of linear equations. In this paper we shall obtain additional conditions for these functions imposed by the constraints.
The Effect of Amorphous Calcium Phosphate Nanoparticles Loaded in Chlorhexidine as an Intra-canal Medicament on Radicular Dentin Microhardness (An In-Vitro Study)

Objectives: This study evaluated the effect of 20% amorphous calcium phosphate nanoparticles loaded in chlorhexidine as an intra-canal medicament, on root canal dentin microhardness. Methods: A total of 30 human permanent single rooted teeth were used in this study. Teeth were decoronated and roots were split longitudinally into two equal halves, the better one half was kept and the other was discarded (30 specimens). The specimens were randomly divided into 3 groups according to the medicament used: 20% amorphous calcium phosphate nanoparticles in chlorhexidine (NACP+CHX), 2% chlorhexidine (CHX) and calcium hydroxide (Ca(OH)2). Each medicament was applied for two weeks immediately after initial baseline microhardness determination. The initial baseline microhardness determination utilized Vickers indenter under a 200-g load and a 15-second dwell time. Post treatment microhardness values were obtained utilizing the same settings. The change in radicular microhardness was calculated as a percentage. Data were statistically analyzed utilizing 1-way analysis of variance (P=.05) and post hoc Tukey test for the multiple comparisons at the same level of significance. The difference between the pre-treatment and the post-treatment microhardness values were statistically analyzed utilizing t-test with a P < . 05. Results: 20% amorphous calcium phosphate nanoparticles in chlorhexidine was the only medicament to result in a statistically significant increase in radicular dentin microhardness, while both 2% chlorhexidine and calcium hydroxide resulted in a statistically significant decrease, with calcium hydroxide having the most detrimental effect. Conclusion: On the contrary of 2% chlorhexidine and calcium hydroxide, 20% amorphous calcium phosphate nanoparticles in chlorhexidine demonstrated a reinforcing effect on radicular dentin microhardness.
Improved model for estimating the biomass of Populus euphratica forest using the integration of spectral and textural features from the Chinese high-resolution remote sensing satellite GaoFen-1

Abstract. Accurate estimation of forest aboveground biomass (AGB) is crucial for monitoring ecosystem responses to environmental change. Optical remote sensing is the most widely used method for obtaining AGB information. However, there is a need for improving the accuracy of AGB estimation obtained in this way. A synergistic estimation model through the integration of spectral and textural features from Chinese high spatial resolution satellite data GaoFen-1 (GF-1) for AGB estimation in the arid region of Ejin Banner, Inner Mongolia Autonomous Region, China, was put forward. The proposed model combined the spectrum-alone model and texture-alone model, which were developed to describe the relationship between image parameters (spectral vegetation indices or texture parameters) obtained from GF-1 data and field measurements, and determined the contributions of spectral and textural sensitive indices to biomass estimation under different biomass conditions. The synergistic model was verified by comparison with the ground measurements and the results of the spectrum-alone and texture-alone models. The results indicate that the proposed synergistic estimation model is more effective than the spectrum-alone or texture-alone model, and shows considerable potential in forest AGB estimation by combining spectral and textural information.
Experimental Investigation of the Spall Propagation Mechanism in Bearing Raceways

This article investigates the spall propagation mechanism for ball bearing raceways by focusing on an experimental investigation of cracks that evolve in the vicinity of the spall edge. Understanding the spall propagation mechanism is an important step towards developing a physics-based prognostic tool for ball bearings. This research reflects an investigation of different spall sizes that propagate naturally both in laboratory experiments and in the field. By using a combined model of a rigid body dynamic model and a finite element model that simulates the rolling element–spall edge interaction, our results shed light on the material behavior (displacements, strains, and stresses) that creates an environment for crack formation and propagation. With the support of the experimental results and the rolling element–spall edge interaction model results, three stages of the mechanism that control fragment release from the raceway were identified. In Stage one, sub-surface cracks appear underneath the spall trailing edge. In Stage two, cracks appear in front of the trailing edge of the spall and, in Stage three, the cracks propagate until a fragment is released from the raceway. These stages were observed in all the tested bearings. In addition, other phenomena that affect the propagation of the cracks and the geometry of the fragment were observed, such as blistering and plastic deformation. We include an explanation of what determines the shape of the fragments.
Stability of a Simple Bioreactor Model with a General Growth Function, Bacterial Feed and Death Rate

Biological reactors are employed in industrial applications to break down organic waste. Here we consider the stability of an open loop CSTR, with a general growth rate function, having both a bacterial and substrate feed and a death rate. Reactors with a bacterial feed are important as every reactor after the first in a cascade will have both bacterial and substrate feeds. We show that stability of a critical point is related to the sign of the slope of the growth rate function, when no bacterial feed is present, and to the sign of the slope of a function, being the product of the growth rate function and a function involving the substrate and bacterial feed concentrations, when a bacterial feed is present.
Heat capacity-driven inverse Soret effect of colloidal nanoparticles

We discuss the thermophoresis of colloidal suspensions and derive their Soret coefficient in terms of known thermodynamic functions. For solid nanoparticles, ST is determined by the ratio of the heat capacities of the solute and the solvent, and is in general much larger than the ideal gas value ST = 1/T. For aqueous suspensions of most solid materials, we obtain a strong inverse Soret effect (ST < 0), whereas a positive sign occurs for common organic solvents such as toluene and cyclohexane. These findings provide an explanation for recent experiments on ferrofluids.
Activities Based Contextual and Constructivist Learning: A Model for Enhancing Students' English Learning Outcomes

Changes from the current curriculum in Indonesia to the Merdeka Belajar (independent learning) curriculum require teachers to make learning more meaningful and fun for students by connecting concepts to the real world. This study aimed to develop a learning model with constructivism and contextual teaching and learning (CTL) approach to improve students’ English skills. The specific objectives of this study are to map the English learning model that has been implemented by teachers, identify the needs of students and teachers for the English learning model, develop a learning model with CTL and constructivism approaches, and test the feasibility of the model. The data were collected through observation, interviews, documentation, questionnaires, and tests in 12 public and private SMP/MTs spread across the Jepara, Demak, and Kudus districts. The collected data were analyzed qualitatively and quantitatively. Based on qualitatively collected data, students and teachers need a learning model that can provide students with learning experiences that are more meaningful. The developed model was proven effective by the value of the effectiveness test where the t-test results show greater than the t-table. Therefore, it implies that the learning models based on CTL and constructivism can be an alternative to the current learning models that can be applied to learning English at school. Keywords: Meaningful activities; contextual learning; constructivism learning.
Can Twisting and Lateral Bending Motions be Controlled through Adjustments to Transfer Distance When Boxes are Lifted from Varying Heights?

Work-related injury to the low back due to twisting and lateral bending motions has been well-documented for manual material handling tasks. Laboratory studies in the past have shown reduction in these motions of the spine by changing the workplace layout. This study investigated differences in spine motions as a function of transfer distance and origin lifting heights. Sixteen subjects were asked to move three boxes from different lift origin heights to a fixed destination for six transfer distances. The results showed that twisting motions decreases with transfer distance and initial lifting height. At lower lifting heights, lateral bending motions were significantly higher.
Blue InGaN-based laser diodes with an emission wavelength of 450 nm

Blue InGaN single-quantum-well-structure laser diodes (LDs) with an emission wavelength of 450 nm were grown on an epitaxially laterally overgrown GaN substrate by a metalorganic chemical vapor deposition method. The threshold current density and voltage were 4.6 kA cm−2 and 6.1 V, respectively. The estimated lifetime was approximately 200 h under room-temperature continuous-wave operation at an output power of 5 mW. When the number of InGaN well layers of the LDs with emission wavelengths longer than 435 nm varied from one to three, the lowest threshold current density was obtained when the number of well layers was one.
On some Ringel-Hall numbers in tame cases

Abstract Let k be a finite field and consider the finite dimensional path algebra kQ, where Q is a quiver of tame type i.e. of type Ãn, D̃n,Ẽ6,Ẽ7,Ẽ8. Let H(kQ) be the corresponding Ringel-Hall algebra. We are going to determine the Ringel-Hall numbers of the form FP`XP with P, P` preprojective indecomposables of defect -1 and FI`IX with I, I` preinjective indecomposables of defect 1. It turns out that these numbers are either 1 or 0.