Miracle-dz/UniFAR-FTUs huggingface dataset:
The epizootic situation of cattle moraxellosis in several economic entities of the Republic of Kazakhstan

Background and Aim: Infectious bovine keratoconjunctivitis (IBK; conjunctivitis) is a widespread eye disease in cattle. In 1960, the Gram-negative bacillus Moraxella bovis was discovered as one of IBK’s etiological causal agents. This study aimed to clarify the epidemiological (epizootic) situation of cattle moraxellosis in the Republic of Kazakhstan. The study also maps the quantitative and qualitative indicators of the epidemiological (epizootic) process to develop more effective antiepizootic measures. Materials and Methods: We clinically examined both imported and local cattle species based on existing epidemiological (epizootological) units of economic entities in Kazakhstan. Then, we selected biomaterials for laboratory tests to screen for moraxellosis. Results: We clarified the epizootic situation for moraxellosis of cattle in Kazakhstan using data from the Meat Union of Kazakhstan, veterinary reports from the Veterinary Control and Surveillance Committee of the Ministry of Agriculture, Kazakhstan, and our results, obtained during visits to farms in the various regions of the republic. Conclusion: Based on the data of the conducted studies, we developed epizootic visualization maps with quantitative indicators of the cattle moraxellosis epizootic-transfer processes within various regions of Kazakhstan for 2019. The data obtained from studies of the properties of the isolated cultures compared with the characteristics of reference strains gave grounds to classify them as belonging to the Moraxella genus.
Citizenship under COVID‐19: An analysis of UK political rhetoric during the first wave of the 2020 pandemic

Abstract The paper presents an analysis of the UK government discourse on citizenship during the first 9 months of the COVID‐19 pandemic (March–November 2020). We adopted a socio‐cultural approach to citizenship drawing on the scholarly tradition of ideological dilemmas and rhetorical psychology as well as interdisciplinary work on neoliberalism. In our analysis of over one hundred briefings and other material by the Prime Minister and members of the Cabinet, we identified five interrelated constructions of the ‘good citizen’: the confined, the heroic, the sacrificial, the unfree and the responsible citizen. The paper maps these constructions onto the ideological dilemmas of freedom/control, passive/active citizenship and individualism/collectivism. We show that, through the rhetorical use of notions of gratefulness for citizens' sacrifice and shared responsibility, the UK government's discourse appears to challenge the dominant model of the neoliberal citizen. However, it solidifies this very same model by responsibilizing individual citizens whilst abdicating itself from responsibility. Please refer to the Supplementary Material section to find this article's Community and Social Impact Statement.
From imperialism to inpatient care: Work differences of Filipino and White registered nurses in the United States and implications for COVID‐19 through an intersectional lens

Abstract In the United States, nursing is the largest healthcare profession, with over 3.2 million registered nurses (RNs) nationwide and comprised of mostly women. Foreign‐trained RNs make up 15 percent of the RN workforce. For over half a century, the U.S. healthcare industry has recruited these RNs in response to nurse shortages in hospitals and nursing homes. Philippines‐trained RNs make up 1 out of 20 RNs in this country and continue to be the largest group of foreign‐trained nurses today. Recently, the news media has publicized the many deaths of Filipino RNs as a result of the COVID‐19 pandemic in the United States. Given the imperial historical ties between these two countries in the context of the nursing profession and the enduring labor inequities that persist, this nationally representative study is one of the few to our knowledge to not only quantitatively examine the current work differences in characteristics and experiences of Philippines‐trained RNs and U.S.‐trained white RNs practicing in the United States today, but to also do so from an intersectionality lens. The overall aim of this paper is to illuminate how these differences may serve as potential factors contributing to the disproportionate number of Filipino nurses' COVID‐19 related vulnerability and deaths in the workplace.
Patterns of medication errors involving pediatric population reported to the French Medication Error Guichet

Background: Medication error is a global threat to patient safety, particularly in pediatrics. Yet, this issue remains understudied in this population, in both hospital and community settings. Objectives: To characterize medication errors involving pediatrics reported to the French Medication Error Guichet, and compare them with medication errors in adults, in each of the hospital and community settings. Methods: This was a retrospective secondary data analysis of medication errors reported throughout 2013-2017. Descriptive and multivariate analyses were performed to compare actual and potential medication error reports between pediatrics (aged <18 years) and adults (aged >18 and <60 years). Two subanalyses of actual medication errors with adverse drug reaction (ADR), and serious ADR were conducted. Results: We analyzed 4,718 medication error reports. In pediatrics, both in hospital (n=791) and community (n=1,541) settings, antibacterials for systemic use (n=121, 15.7%; n=157, 10.4%, respectively) and wrong dose error type (n=391, 49.6%; n=549, 35.7%, respectively) were frequently reported in medication errors. These characteristics were also significantly more likely to be associated with reported errors in pediatrics compared with adults. In the hospital setting, analgesics (adjusted odds ratio (aOR)=1.59; 95% confidence interval (CI) 1.03:2.45), and blood substitutes and perfusion solutions (aOR=3.74; 95%CI 2.24:6.25) were more likely to be associated with reported medication errors in pediatrics; the latter drug class (aOR=3.02; 95%CI 1.59:5.72) along with wrong technique (aOR=2.28; 95%CI 1.01:5.19) and wrong route (aOR=2.74; 95%CI 1.22:6.15) error types related more to reported medication errors with serious ADR in pediatrics. In the community setting, the most frequently reported pediatric medication errors involved vaccines (n=389, 25.7%). Psycholeptics (aOR=2.42; 95%CI 1.36:4.31) were more likely to be associated with reported medication errors with serious ADR in pediatrics. Wrong technique error type (aOR=2.71; 95%CI 1.47:5.00) related more to reported medication errors with ADR in pediatrics. Conclusions: We identified pediatric-specific medication error patterns in the hospital and community settings. Our findings inform focused error prevention measures, and pave the way for interventional research targeting the needs of this population.
NRF2 Loss Accentuates Parkinsonian Pathology and Behavioral Dysfunction in Human α-Synuclein Overexpressing Mice

Nuclear factor (erythroid-derived 2)-like 2 (NRF2) is a central regulator of cellular stress responses and its transcriptional activation promotes multiple cellular defense and survival mechanisms. The loss of NRF2 has been shown to increase oxidative and proteotoxic stress, two key pathological features of neurodegenerative disorders such as Parkinson’s disease (PD). Moreover, compromised redox homeostasis and protein quality control can cause the accumulation of pathogenic proteins, including alpha-synuclein (α-Syn) which plays a key role in PD. However, despite this link, the precise mechanisms by which NRF2 may regulate PD pathology is not clear. In this study, we generated a humanized mouse model to study the importance of NRF2 in the context of α-Syn-driven neuropathology in PD. Specifically, we developed NRF2 knockout and wild-type mice that overexpress human α-Syn (hα-Syn+/Nrf2-/- and hα-Syn+/Nrf2+/+ respectively) and tested changes in their behavior through nest building, challenging beam, and open field tests at three months of age. Cellular and molecular alterations in α-Syn, including phosphorylation and subsequent oligomerization, as well as changes in oxidative stress, inflammation, and autophagy were also assessed across multiple brain regions. It was observed that although monomeric α-Syn levels did not change, compared to their wild-type counterparts, hα-Syn+/Nrf2-/- mice exhibited increased phosphorylation and oligomerization of α-Syn. This was associated with a loss of tyrosine hydroxylase expressing dopaminergic neurons in the substantia nigra, and more pronounced behavioral deficits reminiscent of early-stage PD, in the hα-Syn+/Nrf2-/- mice. Furthermore, hα-Syn+/Nrf2-/- mice showed significantly amplified oxidative stress, greater expression of inflammatory markers, and signs of increased autophagic burden, especially in the midbrain, striatum and cortical brain regions. These results support an important role for NRF2, early in PD progression. More broadly, it indicates NRF2 biology as fundamental to PD pathogenesis and suggests that targeting NRF2 activation may delay the onset and progression of PD.
Hepatoprotective Effects of the Cichorium intybus Root Extract against Alcohol-Induced Liver Injury in Experimental Rats

The effects of the Cichorium intybus root extract (Cii) on alcohol-induced liver disease were investigated using Chang liver cells and male Sprague Dawley rats. Silymarin, a liver-protective agent, was used as a positive control. In cell experiments, after 24 h of treatment with the extract, no cytotoxicity was noted, and death by alcohol was avoided. Migration of Chang liver cells increased after exposure to the extract at a concentration of 400 μg/mL. In animal experiments, alcohol was injected into 6-week-old rats for 1, 3, and 50 days. Oral administration of the drug was performed 30 min before alcohol administration. The control was treated with distilled water, and the drug groups were administered EtOH (40% EtOH + 2.5 mL/kg), EtOH + Cii L (low concentration, 2 mg/kg), EtOH + Cii H (high concentration, 10 mg/kg), or EtOH + silymarin (100 mg/kg). Increased liver weight was observed in the alcohol group, as were increased blood-alcohol concentration and liver damage indicators (glutamic oxalacetic transaminase (GOT), glutamic pyruvate transaminase (GPT), and triglycerides (TG)), decreased alcoholysis enzymes (ADH and ALDH), and increased CYP2E1. In the Cii treatment group, liver weight, blood-alcohol concentration, liver damage indicators (GOT, GPT, and TG), and CYP2E1 were decreased, while alcoholysis enzymes (ADH and ALDH) were increased. The degree of histopathological liver damage was compared visually and by staining with hematoxylin and eosin and oil red O. These results indicated that ingestion of Cii inhibited alcohol-induced liver damage, indicating Cii as a useful treatment for alcohol-induced liver injury.
Prolonged survival after laser interstitial thermal therapy in glioblastoma

Background: Glioblastoma (GBM) is the most common primary malignant brain tumor in adults. Management includes surgical resection followed by chemoradiation, and prognosis remains poor. Surgical resection is not possible for some deep-seated or eloquent tumors. Laser interstitial thermal therapy (LITT) has emerged as a new, minimally invasive surgical option for deep-seated GBM. Case Description: We report a case of newly diagnosed thalamic GBM managed with LITT followed by radiation and chemotherapy. Conclusion: The patient remains well at 50-month post-LITT, indicating a potentially unique durability of LITT treatment in GBM.
Learning from the COVID crisis for educating children and young people with SEN/disabilities

This policy seminar on Learning from the COVID crisis for educating children and young people with SEN/ disabilities, which took place via Zoom on 16 November 2020, addressed these current issues and questions: (1) What has it been possible to provide for the range of SEN since the COVID crisis? How well has provision worked and what has been worse and/or better than before COVID? (2) What has been learned from the experience of the COVID crisis that has affected: Ideas about what education for CYP with SEN/disabilities is about and how future education might be delivered? (3) How are parents thinking about the future of education for their children? For example, increased interest in home schooling for particular group and where not at school has led to reduced stress? Presentations were by Amy Skipp (ASK Research) on ‘Special education during lockdown: Provider and parent experiences’, Sharon Smith (Parent Advocate) on ‘Parents’ perspectives: what can we learn from COVID crisis education for students labelled with SEND’, and Dominic Wall (Executive Principal & SEND Lead for Co-op Academies Trust) on ‘Managing medical complexity in specialist educational settings during COVID’.
Novel Concepts for the Role of Chloride Cotransporters in Refractory Seizures

Epilepsy is associated with a multitude of acquired or genetic neurological disorders characterized by a predisposition to spontaneous recurrent seizures. An estimated 15 million patients worldwide have ongoing seizures despite optimal management and are classified as having refractory epilepsy. Early-life seizures like those caused by perinatal hypoxic ischemic encephalopathy (HIE) remain a clinical challenge because although transient, they are difficult to treat and associated with poor neurological outcomes. Pediatric epilepsy syndromes are consistently associated with intellectual disability and neurocognitive comorbidities. HIE and arterial ischemic stroke are the most common causes of seizures in term neonates and account for 7.5-20% of neonatal seizures. Standard first-line treatments such as phenobarbital (PB) and phenytoin fail to curb seizures in ~50% of neonates. In the long-term, HIE can result in hippocampal sclerosis and temporal lobe epilepsy (TLE), which is the most common adult epilepsy, ~30% of which is associated with refractory seizures. For patients with refractory TLE seizures, a viable option is the surgical resection of the epileptic foci. Novel insights gained from investigating the developmental role of Cl- cotransporter function have helped to elucidate some of the mechanisms underlying the emergence of refractory seizures in both HIE and TLE. KCC2 as the chief Cl- extruder in neurons is critical for enabling strong hyperpolarizing synaptic inhibition in the brain and has been implicated in the pathophysiology underlying both conditions. More recently, KCC2 function has become a novel therapeutic target to combat refractory seizures.
A perspective on wrong level, wrong side, and wrong site spine surgery

Background: Four of the most common “errors” in spine surgery include: operating on the wrong patient, doing the wrong procedure, performing wrong-level surgery (WLS), and/or performing wrong-sided surgery (WSS). Although preoperative verification protocols (i.e. Universal Protocol, routine Time-Outs, and using the 3 R’s (i.e. right patient, right procedure, right level/side)) have largely limited the first two “errors,” WLS and WSS still occur with an unacceptably high frequency. Methods: In 20 studies, we identified the predominant factors contributing to WLS/WSS; unusual/anatomical anomalies/variants (i.e. sacralized lumbar vertebrae. lumbarized sacral vertebra, Klippel-Feil vertebrae, block vertebrae, butterfly vertebrae, obesity/morbid obesity), inadequate/poor interpretation of X-rays/fluoroscopic intraoperative images, and failure to follow different verification protocols. Results: “Human error” was another major risk factor contributing to the failure to operate at the correct level/side (WLS/WSS). Factors comprising “human error” included; surgeon/staff fatigue, rushing, emergency circumstances, lack of communication, hierarchical behavior in the operating room, and failure to “speak up”. Conclusion: Utilizing the Universal Protocol, routine Time Outs, and the 3 R’s largelly avoid operating on the wrong spine patient, and performing the wrong procedure. However, these guidelines have not yet sufficiently reduced the frequently of WLS and WSS. Greater recognition of the potential pitfalls contributing to WLS/WSS as reviewed in this perspective should better equip spine surgeons to avert/limit such “errors” in the future.
Impact of retrofitting work on vulnerability reduction of local buildings in Kabul, Afghanistan

Rapid urbanisation of Afghan cities without proper construction regulation has exposed their population to a high risk of damage from disasters such as earthquakes. With the growing construction of local non-engineered buildings and an existing level of hazard of 0.8 g, a high risk of casualties and building damage threatens Kabul in the event of a disaster. This study reports and evaluates a recent retrofitting project in Kabul City by ‘Project for City Resilience’, carried out under the supervision of the United Nation Human Settlements Program (UN-Habitat) for 48 retrofitted sun-dried clay brick masonry buildings in Kabul. The project was executed by local masons and welders who were trained as a part of the project, and the main tasks included installation of an additional steel frame, additional reinforced concrete foundation ring, ceiling replacement and wall strengthening (via mesh and plaster). After a visual assessment of retrofitted buildings considering the original retrofitting design and actual work done, a vulnerability index for retrofitted buildings was developed based on a behaviour modifier factor, which was assigned to each retrofitting activity using a combination of values and a proportion of scores for each retrofitting activity. The results indicate that training of local masons and welders to undertake retrofitting activities could decrease the damage ratio by 15% – 20% for peak ground acceleration values of 0.3 g and higher. The methods mentioned in this study can be used to make existing sun-dried clay brick masonry buildings sufficiently resistant to earthquakes of moderate-to-severe intensity.
Treatment of methicillin-resistant Staphylococcus aureus (MRSA): updated guidelines from the UK

Abstract These evidence-based guidelines are an updated version of those issued in 2008. They have been produced following a review of the published literature (2007–18) pertaining to the treatment of infections caused by MRSA. The guidelines update, where appropriate, previous recommendations, taking into account changes in the UK epidemiology of MRSA, ongoing national surveillance data and the efficacy of novel anti-staphylococcal agents licensed for use in the UK. Emerging therapies that have not been licensed for use in the UK at the time of the review have also been assessed.
Cultural Considerations in Palliative Care Provision: A Scoping Review of Canadian Literature

Background: Palliative care, a division of health care that provides treatment to patients facing terminal or incurable illness, prioritizes maintaining quality of life for the patients it serves. Factors that influence quality of life are highly individualized, encompassing social, economic, or cultural determinants of health. In particular, cultural determinants remain an understudied element of palliative care. Objectives: The purpose of this article is to identify key concepts and issues arising from offering culturally relevant palliative care by reviewing how the concept of culture has been discussed in Canadian palliative care literature. Design: A scoping review of medical databases was conducted to identify recent Canadian literature connecting culture and palliative care provision. This review yielded 21 relevant results from the past 10 years. Results: Ideas frequently mentioned in Canadian palliative care literature include cultural competency in health care providers, cultural sensitivity of treatment options, and cultural accessibility of available services. Issues that arose from the literature included differing ideas of the meanings of life and death, visibility of cultural minority groups, spiritual care needs, desire to involve friends and family in care, and misunderstandings of language and communication styles. Conclusion: The results of this review provide a starting point from which health care providers can begin lending attention to cultural determinants of health, thus improving palliative care services for diverse populations.
Performance of Swarnadhara breeder hens supplemented with reduced levels of different copper forms

Background and Aim: Copper (Cu) is a vital mineral involved in various physiological and biochemical processes, growth, and productivity of animals and birds. Birds can absorb only a small fraction of Cu and most is excreted, contaminating soil and aquatic environment which is toxic for microorganisms, plants, animals, and humans. This study evaluated the possibility of use of organic and nanoparticles sources of Cu to reduce supplementation level without compromising the performance of breeder hens. Materials and Methods: A total of 224 Swarnadhara breeder hens were divided into seven treatment groups having four replicates in each. The basal diet (control) containing 20 ppm inorganic Cu (100% of standard recommendation) and six test diets containing 20, 15, and 10 ppm (100, 75, and 50% of standard recommendation) from Cu organic source, and 15, 10, and 5 ppm (75, 50, and 25%) from Cu nanoparticles (Cu-NP), were prepared and offered to respective treatment groups for a duration of 20 weeks. Results: The hen day egg production, hen housed egg production, feed conversion ratio egg mass, albumen index, yolk index, total fat content, and color score were not affected by the source and inclusion level of Cu. The feed intake was significantly (p<0.05) lower at 15 ppm and egg weight was significantly (p<0.05) higher at 10 ppm Cu-NP supplemental level, but was non-significant in other treatment groups compared to control. The body weight gain was significantly (p<0.05) higher at 20 ppm organic and 15 ppm Cu-NP inclusion. The egg shape index and Haugh unit were significantly (p<0.05) lower at 10 and 15 ppm of Cu-NP inclusion level, respectively. The shell thickness was improved (p<0.05) at 20 and 15 ppm organic and 15 and 10 ppm Cu-NP inclusion level. The egg fertility rate was shown to be significantly (p<0.05) higher at 20 ppm organic Cu inclusion group, but the hatchability based on total number of eggs set improved (p<0.05) at 20 and 15 ppm organic Cu inclusion level while all treatment groups were comparable to control. The hatchability of fertilized egg and chick’s quality significantly (p<0.05) improved, while embryonic and chick mortality after hatching before-sorting was significantly (p<0.05) reduced at 15 ppm of Cu-NP inclusion group. Conclusion: It was concluded that the inorganic Cu can be replaced with 50% of organic or 25% of nanoparticles form of Cu without jeopardizing the breeder hens’ productivity, egg quality characteristics, hatchability, and progeny.