Miracle-dz/UniFAR-FTUs huggingface dataset:
Influence of Belatacept- vs. CNI-Based Immunosuppression on Vascular Stiffness and Body Composition

Background: Arterial stiffness and phase angle (PhA) have gained importance as a diagnostic and prognostic parameter in the management of cardiovascular disease. There are few studies regarding the differences in arterial stiffness and body composition between renal transplant recipients (RTRs) receiving belatacept (BELA) vs. calcineurin inhibitors (CNI). Therefore, we investigated the differences in arterial stiffness and body composition between RTRs treated with different immunosuppressants, including BELA. Methods: In total, 325 RTRs were enrolled in the study (mean age 52.2 years, M −62.7%). Arterial stiffness was determined with an automated oscillometric device. All body composition parameters were assessed, based on bioelectrical impedance analysis (BIA), and laboratory parameters were obtained from the medical files of the patients. Results: We did not detect any significant difference in terms of arterial stiffness and PhA in RTRs undergoing different immunosuppressive regimens, based on CsA, Tac, or BELA. Age was an essential risk factor for greater arterial stiffness. The PhA was associated with age, BMI, time of dialysis before transplantation, and kidney graft function. Conclusion: No significant differences in arterial stiffness and PhA were observed in RTRs under different immunosuppressive regimens. While our data provide additional evidence for arterial stiffness and PhA in RTRs, more research is needed to fully explore these cardiovascular risk factors and the impact of different immunosuppressive regimens.
Azadirachta indica A. juss, Morinda citrifolia L. and Triphala as herbal endodontic irrigants: A scoping review

Background: The success of the root canal treatment depends on the complete elimination of the microflora, biofilms and smear layer from the pulp space. A wide variety of chemical endodontic irrigants are available to achieve disinfection and thorough debridement besides mechanical means. However, detrimental properties such as allergic potential, cytotoxicity, antimicrobial resistance and safety concerns have intrigued researchers over the years to look for safer options. Aim: The review is aimed at providing comprehensive information of the studies evaluating the efficacy of Azadirachta indica A. juss (A. indica), Morinda citrifolia L. (M. citrifolia) and Triphala (fruits of Emblica officinalis Gaertn., Terminalia chebula (Gaertn.) Roxb. and Terminalia belerica Retz. ) as herbal endodontic irrigants. Materials and methods: The literature review was conducted using indexed databases (PubMed, Google Scholar, Cochrane) electronically for publications in peer-reviewed journals for relevant articles evaluating the efficacy of A. indica, Triphala, M. citrifolia as endodontic irrigant from the year 1985-March 2020. Results: A total of 58 studies were identified for full text reviewing after duplicate removal and screening title and abstracts. A total of 32 studies were included and processed for data extractions. Conclusion: Various in-vitro/in-vivo studies utilizing these herbal irrigants have documented promising results and hold the potential to replace chemical endodontic irrigants in routine practice but more preclinical and clinical trials are needed to substantiate these results before they can conclusively be recommended as intracanal irrigating solutions.
Analysis of convexity results for discrete fractional nabla operators

We investigate the relationship between the sign of the discrete fractional difference ( ∇af ) (t) and the convexity of the function f in the case where 2 < ν < 3. We focus on the scenario in which ( ∇af ) (t) satisfies a negative lower bound. Our analytical results are complemented with numerical simulations, the latter providing insight beyond what we are able to produce analytically.
Optimization of human cancer cell xenograft into zebrafish larvae for anti-cancer drug screening

Transplant of human cancer cells into zebrafish larvae has emerged as a useful methodology in cancer research. Zebrafish have very low husbandry costs, are amenable to largescale drug screening, and are unmatched for optical clarity in live animal imaging. However, there is currently no consensus on the ideal methods for xenograft of human cancer cells into zebrafish. Here, we have examined the effects of transplant site and housing temperature on both zebrafish larvae and human cancer cells using survival analyses, metabolomic approaches, and in vivo imaging. Our data show that while zebrafish larvae can adapt to the ideal conditions for mammalian cells, human cancer cells are highly sensitive to both temperature change and transplant site. Human cells housed in slightly cooler than physiologic temperatures had a significantly altered metabolism that resulted in changes in growth, survival, and response to chemotherapy. Cancer cells xenografted into the yolk of the larvae also had reduced proliferation and drug response compared to those xenografted into the soma, in part due to the differences in metabolites available at these sites. In total, temperature and transplant site can have profound effects on xenografted cells. Standardization of zebrafish xenograft methods will enhance data reproducibility between individual laboratories.
INTERNATIONAL JOURNAL OF MULTIDISCIPLINARY: APPLIED BUSINESS AND EDUCATION RESEARCH

Issues on plagiarism among pre-service teachers (PSTs) have increased in modular and online learning. To confirm this, the study determined the PSTs’ level of awareness on plagiarism; their knowledge on referencing and citation; and the correlation between their level of awareness on plagiarism and knowledge on referencing and citation, with their academic performance. The study employed a descriptive-correlational research design participated by 235 PSTs randomly sampled through strata. The data were gathered through a web-based survey. Results showed that the PSTs’ level of awareness of plagiarism was moderate, while the majority have fair knowledge in referencing and citation. Also, results showed a significant relationship among the level of awareness on plagiarism, knowledge on referencing and citation, and academic performance. It is recommended that institutions equip librarians and educators to teach PSTs about citation and referencing skills. Besides, the institution should make sure that a policy is implemented to pursue academic integrity. This policy must articulate the various types of plagiarism, plagiarism measurement, and fair and consistent disciplinary actions.
SEISMIC FRAGILITY ASSESSMENT OF STEEL X-BRACED AND CHEVRON-BRACED RC FRAMES

Seismic vulnerability assessment for steel X-braced and chevron-braced RC frames has been performed via development of analytical fragility curves. Several parameters including the height of the frame, the P-Δ effect, the fraction of base shear for which the bracing system has been designed and type of bracing system have been investigated. Definition of damage states based on the descriptions as provided by HAZUS which gives the limit states and the associated inter-storey drift limits for RC buildings has been used. The results of fragility curves show that strengthening the concrete frames by internal steel bracing can reduce the probability of damage and this reduction is higher when chevron bracing system is used.
OPTO_A_355091 13..25

This review of commonly prescribed psychotropic drugs aims to update the clinician on possible ophthalmic side effects that may include dry eye, diplopia, mydriasis, and cataracts. This review summarizes our current knowledge of known ocular side effects of psychotropic drugs based on reviews, case reports, case-control studies, a case series, and cross-sectional observational studies reported in the recent literature. The review covers disorders related to depression, anxiety, and stress which are commonly encountered within society and can have debilitating impacts on an individual’s quality of life that may require chronic therapeutic management. The main medications used in the treatment and management of these conditions typically target receptors, metabolic enzymes, or transport pumps that alter the preand/or post-synaptic levels of neurotransmitters such as serotonin, norepinephrine, dopamine, gammaaminobutyric acid, and opioids to improve mood and/or relieve pain and anxiety. Novel non-therapeutic options are undergoing clinical trials, and some patients may seek alternative therapies or have associated substance abuse issues to alleviate their symptoms. This review summarizes some of the clinical signs of depression and the main therapeutic options and their reported ocular side effects which may be pertinent today given the rise in use of psychotropic medications used to manage depression, anxiety, and stress.
The Impact of Microcredit Access on the Well-Being of the Poor in Developing Countries: A Randomized Study in Hyderabad, India Revisited

Microfinance is a banking service provided to low-income individuals or groups that would have limited access to financial services otherwise. Its proponents argue that microlending in developing countries should lift borrowers out of poverty by enabling them to gain access to funds to create and grow businesses. Since microfinance was made available at a large scale in 1976 by Muhammad Yunus and the Grameen Bank, microfinance has become increasingly popular in developing countries as a means to fight poverty, winning them the Nobel Peace Prize in 2006. The question of the legitimate effectiveness of microcredit access on poverty alleviation thus arises. Using data from a randomized study in Hyderabad, India and in controlling for the overall growth of outcome averages used to describe poverty, I firstly show that microcredit access has even less of an impact on poverty alleviation at the aggregate level than what is currently shown in the literature. Moreover, I show using an instrumental approach that at the borrower level, we obtain similar results to those of the current literature on the aggregate impact of MFI access. After presenting these results, I then discuss the potential furthering of the current literature on microfinance as a means of poverty alleviation as well as discuss policy and measures to improve MFI effectiveness.
The Playful Affordances of Picture Book Apps for Children

The tradition of children’s literature has evolved side by side with the market of children’s entertainment, games, and toys. The selection of contemporary print products includes a wide variety of materially or technologically enhanced picture books. This background is rarely considered in the examination of children’s book applications that have attracted scholarly interest after the arrival of smartphones and tablets during the early 2010s.The relationship between picture book apps, mobile games, and digital playthings requires further examination that considers the specific affordances of the mobile platform. Leaning on five case studies, this article examines how picture book apps afford opportunities for a reading experience that contains features characteristic for children’s digital play. For this purpose, I adapt a specific model of close reading that focuses on the visual, auditory, tactile, and performative elements of children’s video games.On the basis of the case studies, it seems that navigating a picture book app requires balancing between different modes of action: reading, playing, and exploring. Engagement with picture book apps has different forms that resemble the features of both traditional print reading and digital play. However, further examination of children’s playful reading practices and intergenerational play is necessary from a premise that recognizes playing with a book as a valuable research topic.
Stability of the explant in the in vitro proliferation of axillary shoots of the biznaga

To conserve ex situ, promote the use and enhancement of native germplasm of ornamental interest such as T. viereckii subsp. major, a species at risk Pr, the present research was proposed with the aim of regenerating this species in the Plant Tissue Culture Laboratory (LCTV) of the Saltillo CIRNE-INIFAP Experimental Field considering the stability of the explant during subsequent subcultures, determine the type and concentration of phytohormones and the best cytokinin-auxin ratio that most influence the in vitro multiplication stage. The intermediate segments of the stem (SIT) obtained from vitroplants was used as an explant. From 2017 to 2019, the multiplication stage was evaluated using the Murashige-Skoog medium (MS; Murashige and Skoog, 1962) at 50% of its macrosalts. A completely randomized experimental design with factorial arrangement was used to evaluate two cytokinins: 6-benzyl aminopurine (BAP) and 6-furfuryl aminopurine (KIN) at four concentrations 2.5, 5, 7.5 and 10 mg L in interaction with two auxins: naphthaleneacetic acid (NAA) and indole butyric acid (IBA) in a cytokinin-auxin ratio of 10:1. In total, 16 treatments were evaluated, establishing five SIT/bottle with 10 repetitions/treatment. This evaluation was repeated five times by means of subcultures, evaluating the number of shoots/explant (Nb) and the shoot height (Ab, mm) every ten weeks. The analysis of variance (Anova) showed that there was stability of the explant during the subcultures, maintaining a similar multiplication rate for more than three years, an important effect for intensive multiplication. When analyzing the treatments as independent effects in the Tukey mean test (p≤ 0.05), the interactions BAP: IBA and KIN: IBA with concentrations of 5 mg L BAP + 0.50 mg L IBA and 2.5 mg L KIN + 0.25 mg L IBA were selected as the treatments that induce shoots with a multiplication rate of 9.25 shoots/explant with an Ab of 6.73 mm.
Identi cation of Candidate Genes that Speci cally Regulate Subcutaneous and Intramuscular Fat Deposition Using Transcriptomic and Proteomic Pro les in Dingyuan Pigs

Pan Zhang China Agricultural University Qinggang Li Anhui Academy of Agricultural Sciences Yijing Wu Anhui Academy of Agricultural Sciences Yawen Zhang China Agricultural University Hao Zhang China Agricultural University https://orcid.org/0000-0002-7331-1550 Bo Zhang (  bozhang0606@cau.edu.cn ) National Engineering Laboratory for Animal Breeding, China Agricultural University, Beijing 100193, China
Effect of organic and inorganic fertilization on the production and quality of Brachiaria brizantha

The yield and bromatological composition of two cultivars of Brachiaria brizantha (Sinaí and Xaraés), in two soil types and three types of fertilizer, were evaluated by a completely randomized design with factorial arrangement (2x2x3) with four repetitions. The variables studied were yields of green matter, dry matter, number of leaves, as well as plant height, crude protein, the contents of calcium, phosphorus and crude fiber. The fertilizer factor had a positive effect on the variable plant height. With the application of bovine manure, the highest average height of 96.06 cm was obtained. At 21 days, the highest green matter yield of 756.2 kg ha was obtained with the mineral fertilizer. The dry matter content was significantly influenced by the triple interaction (p≤ 0.05), where Sinaí achieved the highest average value of 132.5 kg ha at 21 days of regrowth. The highest average CP content was found in plants of both varieties that received chemical fertilization. The highest average Ca content was found in Sinaí (1.9%) and Xaraés (2.08%), which received organic fertilization. While the highest average content of P was found in Xaraés (0.42%) with the application of AMF. Finally, the Sinaí plant that received bovine manure in sterilized soil had a higher average CF content (27.27%). Organic and inorganic fertilization had a significant effect on grass yield and nutritional quality.
Understanding Privacy-Related Advice on Stack Overflow

Abstract Privacy tasks can be challenging for developers, resulting in privacy frameworks and guidelines from the research community which are designed to assist developers in considering privacy features and applying privacy enhancing technologies in early stages of software development. However, how developers engage with privacy design strategies is not yet well understood. In this work, we look at the types of privacy-related advice developers give each other and how that advice maps to Hoepman’s privacy design strategies. We qualitatively analyzed 119 privacy-related accepted answers on Stack Overflow from the past five years and extracted 148 pieces of advice from these answers. We find that the advice is mostly around compliance with regulations and ensuring confidentiality with a focus on the inform, hide, control, and minimize of the Hoepman’s privacy design strategies. Other strategies, abstract, separate, enforce, and demonstrate, are rarely advised. Answers often include links to official documentation and online articles, highlighting the value of both official documentation and other informal materials such as blog posts. We make recommendations for promoting the under-stated strategies through tools, and detail the importance of providing better developer support to handle third-party data practices.
DMSO_A_349528 559..577

Background: The pathogenesis of acute pancreatitis (AP) and the relationship between acute pancreatitis and hypertriglyceridemia are complex and not fully understood. The purpose of this study was to identify the hub genes along with common differentially expressed genes (DEGs) between acute pancreatitis and hypertriglyceridemia. Methods: We downloaded three gene expression profiles of AP and one gene expression profile of hypertriglyceridemia from the Gene Expression Omnibus (GEO) database and filtered the DEGs based on the above four datasets. Next, we identified the hub genes by performing the Gene Ontology (GO) term analysis, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis, and protein–protein interaction (PPI) construction. We also constructed the miRNA-hub gene network and established mouse models with hypertriglyceridemia and AP using a high-fat diet and injection of caerulein (CAE), respectively. Finally, the immunohistochemical analysis was used to verify the differential expressions of hub genes in AP, hypertriglyceridemia, and normal pancreatic tissue. Results: A total of 105 DEGs associated with AP and 149 DEGs associated with hypertriglyceridemia were identified. Additionally, we identified six hub genes of AP, all of which were closely related to the cytoskeleton while two DEGs genes were common in both AP and hypertriglyceridemia. We also verified their expression in mouse models. Finally, a network of miRNA-mRNA was also constructed, and the top seven interactive miRNAs (hsa-mir-1–3p, hsa-mir-5195–3p, hsa-mir-145–5p, hsa-let-7b-5p, hsa-mir-10b-5p, hsa-mir-206, and hsa-mir-613) targeting the most hub genes were identified. Conclusion: Overall, we identified six hub genes associated with AP and two common DEGs associated with AP and hypertriglyceridemia along with seven miRNAs that may regulate AP. This study could provide new ideas for further elucidation of the pathogenesis of hypertriglyceridemia-induced acute pancreatitis in the future.
Machine Learning for Monitoring Forest Restoration

Forest restoration is the process of planting, protecting and conserving trees. The recent investment in global forest restoration initiatives has huge potential in mitigating the effects of climate change. However, at present, restoration projects are surveyed using methods which are ineffective for monitoring projects at scale. Furthermore, previous approaches to apply machine learning for forest monitoring have focused on using low-resolution satellite imagery which are not well suited for identifying small planted trees in forest restoration sites. The primary objective of this project is therefore to investigate the possibility of monitoring reforestation projects using machine learning and high-resolution satellite imagery. To achieve this research aim, a unique dataset was manually constructed using high-resolution satellite imagery. Here, we present a random forest machine learning model which is trained on this unique dataset and is evaluated on a real-life forest restoration site in northern Fiji. The results demonstrate that the proposed model, RF-Ranger, can achieving promising 96.4% classification accuracy and 96.3% Macro-F1 score on unseen pixels in a test dataset. This study was conducted in partnership with the non-profit environmental organisation, Conservation International (CI), who manage the active reforestation site assessed in this report. Overall, the results indicate that the proposed model, RF-Ranger, can successfully identify trees in forest restoration sites and can be used to monitor these projects at scale.
Alcohol ignition interlock devices

To prevent drinking and driving, alcolock (or alcohol-interlock) devices and programs were introduced in Sweden in 1999. Two types of prevention programs were begun. A primary prevention strategy was initiated to prevent alcohol impaired driving by individuals not preselected for having prior DWI (driving-while-intoxicated) offences. This approach was first applied as a pilot project in three commercial transport companies (buses, trucks, taxis). In addition, a secondary prevention trial was begun as a voluntary 2-year program for DWI offenders involving strict medical requirements, including counseling and regular checkups by a medical doctor. The program did not require a prior period of hard suspension and focused on changing alcohol use habits. After some early problems/hesitation, alcolocks in commercial vehicles have finally been well accepted by professional drivers, their employers, and their passengers. Because of public interest, the commercial operators in the supported pilot project have continued using the alcolock devices, and the number of vehicles with alcolocks as a primary prevention measure is rapidly growing in Sweden. We found that 3 of 1000 starts in the primary prevention program were blocked by the alcolock after measuring a BAC (blood alcohol concentration) higher than the legal limit and lock point of . 02% (20 mg/dl). The results from the secondary prevention strategy are limited as only 11% of eligible DWI offenders took part in this voluntary program. Of these, 60% had diagnoses of alcohol dependence or abuse and 68% selfreported dangerous or harmful alcohol habits when starting the 2-year program. During the program, alcohol consumption generally decreased significantly as measured through five biological alcohol markers, and the rate of DWI recidivism fell sharply from a yearly rate of approximately 5% to almost zero. Successful completion of the program appears to have lasting effects in terms of far lower rates of DWI recidivism, even 2.5 years later. The effects on DWI recidivism are paralleled by reduced rates of traffic accidents involving injuries. Hard suspension seems almost to have an adverse effect on DWI recidivism, but crashes resulting in injuries may be reduced during revocation.