Miracle-dz/UniFAR-FTUs huggingface dataset:
Grooming behavior in goitered gazelles: the programmed versus stimulus-driven hypothesis

Self-grooming is the most commonly observed behavior and serves numerous functions, with the removal of ectoparasites likely the most important. According to a predominant conception, grooming is regulated by two mechanisms: a programmed-grooming model and a stimulus-driven model. The programmed-grooming model predicts, first, that smaller body-size females must groom more frequently compared to larger males (body-size principle); second, the smaller young groom significantly more often than adults (developmental grooming); and third, rutting males, busy with social vigilance, groom significantly less often than females (vigilance principle). The impact of molting was also tested on the grooming rate as an additional hypothesis that is not a part of the programmed-grooming model. According to investigations of a wide variety of ungulates in captive and natural conditions, the predictions of the programmed-grooming mechanism were found to be accurate for most sexually dimorphic ungulates. Here, I tested the principles of the programmed-grooming model in free living, wild goitered gazelles (Gazella subgutturosa), which are parasitized by both keds and ticks. My study found the following: (a) the body-size principle was not supported by my data, especially during the gazelles’ molting and rutting periods; (b) the developmental grooming model did not relate to the grooming behavior of goitered gazelle fawns; (c) the vigilance principle was not applicable to male goitered gazelles; and (d) spring molting increased the grooming rate drastically for both males and females and likely had the greatest effect over any other factor, even though keds also contributed to the grooming rate at this time. Though previous studies of tick parasitism on many ungulate species demonstrated that oral grooming was more consistent with programmed-grooming than the stimulus-driven grooming model, my study of ked parasitism of goitered gazelles showed the opposite, suggesting that grooming driven mechanisms were parasite-host dependent. However, grooming behavior is likely a multifaceted phenomenon depending not only on body size, vigilance rate or even from ectoparasite burden, but also on numerous other factors.
Hyperthermia: A Potential Game-Changer in the Management of Cancers in Low-Middle-Income Group Countries

Simple Summary As per the Global Cancer Observatory, in 2020, 59% of all cancers globally have been reported from the low-middle-income group countries (LMICs). Cancers of the breast, cervix and head and neck constitute around one-third of the cancers in the LMICs. Most of them are in advanced stages and thus deemed inoperable. Chemoradiotherapy is usually advocated for treatment of these cases with limited success. Moderate hyperthermia at 40–44 °C is a multifaceted therapeutic modality. It is a potent radiosensitizer, chemosensitizer and enforces immunomodulation akin to “in situ tumour vaccination”. The safety and benefit of addition of hyperthermia to radiotherapy and/or chemotherapy in these sites have been well documented in various phase III randomized clinical trials and meta-analysis. Thus, including hyperthermia in the therapeutic armamentarium of clinical care, especially in the LMICs could be a potential game-changer and provide a cost-effective addendum to the existing therapeutic options, especially for these tumour sites. Abstract Loco-regional hyperthermia at 40–44 °C is a multifaceted therapeutic modality with the distinct triple advantage of being a potent radiosensitizer, a chemosensitizer and an immunomodulator. Risk difference estimates from pairwise meta-analysis have shown that the local tumour control could be improved by 22.3% (p < 0.001), 22.1% (p < 0.001) and 25.5% (p < 0.001) in recurrent breast cancers, locally advanced cervix cancer (LACC) and locally advanced head and neck cancers, respectively by adding hyperthermia to radiotherapy over radiotherapy alone. Furthermore, thermochemoradiotherapy in LACC have shown to reduce the local failure rates by 10.1% (p = 0.03) and decrease deaths by 5.6% (95% CI: 0.6–11.8%) over chemoradiotherapy alone. As around one-third of the cancer cases in low-middle-income group countries belong to breast, cervix and head and neck regions, hyperthermia could be a potential game-changer and expected to augment the clinical outcomes of these patients in conjunction with radiotherapy and/or chemotherapy. Further, hyperthermia could also be a cost-effective therapeutic modality as the capital costs for setting up a hyperthermia facility is relatively low. Thus, the positive outcomes evident from various phase III randomized trials and meta-analysis with thermoradiotherapy or thermochemoradiotherapy justifies the integration of hyperthermia in the therapeutic armamentarium of clinical management of cancer, especially in low-middle-income group countries.
Outside Training of Spanish University Students of Education for the Didactic Application of Cinema: Formal, Non-Formal, and Informal Perspectives

Nowadays, audiovisual media play a central role in access to information and in personal relationships. Among the audiovisual media is cinema, which due to its heterogeneous nature, can fulfill diverse educational functions. The objective of this study was to learn about the training that future teachers in Spain receive outside of their teaching degree for the didactic use of cinema. In addition, we sought to understand the influence of training on perceptions regarding the educational potential of cinema and the predisposition to its use. Using a quantitative approach, information was collected from 4659 students from 58 Spanish universities. The questionnaire used covered perceptions about the potencialities of cinema as a didactic resource in pre-school and primary classrooms (PECID). The results showed that 95.1% of the students had not received training. In addition, we found a significant influence of training on their perceptions of the educational possibilities of cinema. Furthermore, we found an influence on their predisposition to use training in their future teaching practice. Overall, it is necessary to implement training actions to fill the gaps detected in favor of a quality education with active learning and linked to society.
Radon Hazard in Central Italy: Comparison among Areas with Different Geogenic Radon Potential

Radon (222Rn) is a natural radioactive gas formed in rocks and soil by the decay of its parent nuclide (238-Uranium). The rate at which radon migrates to the surface, be it along faults or directly emanated from shallow soil, represents the Geogenic Radon Potential (GRP) of an area. Considering that the GRP is often linked to indoor radon risk levels, we have conducted multi-disciplinary research to: (i) define local GRPs and investigate their relationship with associated indoor Rn levels; (ii) evaluate inhaled radiation dosages and the associated risk to the inhabitants; and (iii) define radon priority areas (RPAs) as required by the Directive 2013/59/Euratom. In the framework of the EU-funded LIFE-Respire project, a large amount of data (radionuclide content, soil gas samples, terrestrial gamma, indoor radon) was collected from three municipalities located in different volcanic districts of the Lazio region (central Italy) that are characterised by low to high GRP. Results highlight the positive correlation between the radionuclide content of the outcropping rocks, the soil Rn concentrations and the presence of high indoor Rn values in areas with medium to high GRP. Data confirm that the Cimini–Vicani area has inhalation dosages that are higher than the reference value of 10 mSv/y.
Changes in Body Composition and Strength after 12 Weeks of High-Intensity Functional Training with Two Different Loads in Physically Active Men and Women: A Randomized Controlled Study

This study examined the effects of two different resistance loads during high-intensity Functional Training (HIFT) on body composition and maximal strength. Thirty-one healthy young individuals were randomly assigned into three groups: moderate load (ML: 70% 1-RM), low load-(LL: 30% 1-RM), and control (CON). Each experimental group performed HIFT three times per week for 12 weeks with a similar total volume load. Body fat decreased equally in both experimental groups after 6 weeks of training (p < 0.001), but at the end of training it further decreased only in LL compared to ML (−3.19 ± 1.59 vs. −1.64 ± 1.44 kg, p < 0.001), with no change in CON (0.29 ± 1.08 kg, p = 0.998). Lean body mass (LBM) increased after 6 weeks of training (p = 0.019) in ML only, while after 12 weeks a similar increase was observed in LL and ML (1.11 ± 0.65 vs. ML: 1.25 ± 1.59 kg, p = 0.034 and 0.013, respectively), with no change in CON (0.34 ± 0.67 kg, p = 0.991). Maximal strength increased similarly in four out of five exercises for both experimental groups by between 9.5% and 16.9% (p < 0.01) at the end of training, with no change in CON (−0.6 to 4.9%, p > 0.465). In conclusion, twelve weeks of HIFT training with either low or moderate resistance and equal volume load resulted in an equal increase in LBM and maximal strength, but different fat loss.
Electrochemical Properties of Phytosynthesized Gold Nanoparticles for Electrosensing

Gold nanoparticles are widely used in electrosensing. The current trend is to phytosynthesize gold nanoparticles (phyto-AuNPs) on the basis of the “green” chemistry approach. Phyto-AuNPs are biologically and catalytically active, stable and biocompatible, which opens up broad perspectives in a variety of applications, including tactile, wearable (bio)sensors. However, the electrochemistry of phytosynthesized nanoparticles is not sufficiently studied. This work offers a comprehensive study of the electrochemical activity of phyto-AuNPs depending on the synthesis conditions. It was found that with an increase in the aliquot of the plant extract, its antioxidant activity (AOA) and pH, the electrochemical activity of phyto-AuNPs grows, which is reflected in the peak potential decrease and an increase in the peak current of phyto-AuNPs electrooxidation. It has been shown that AOA is an important parameter for obtaining phyto-AuNPs with desired properties. Electrodes modified with phyto-AuNPs have demonstrated better analytical characteristics than electrodes with citrate AuNPs in detecting uric and ascorbic acids under model conditions. The data about the phyto-AuNPs’ electrochemistry may be useful for creating highly effective epidermal sensors with good biocompatibility.
The Radius of Influence Myth

Empirical formulas to estimate the radius of influence, such as the Sichardt formula, occasionally appear in studies assessing the environmental impact of groundwater extractions. As they are inconsistent with fundamental hydrogeological principles, the term “radius of influence myth” is used by analogy with the water budget myth. Alternative formulations based on the well-known de Glee and Theis equations are presented, and the contested formula that estimates the radius of influence by balancing pumping and infiltration rate is derived from an asymptotic solution of an analytical model developed by Ernst in 1971. The transient state solution of this model is developed applying the Laplace transform, and it is verified against the finite-difference solution. Examining drawdown and total storage change reveals the relations between the presented one-dimensional radial flow solutions. The assumptions underlying these solutions are discussed in detail to show their limitations and to refute misunderstandings about their applicability. The discussed analytical models and the formulas derived from it to estimate the radius of influence cannot be regarded as substitutes for advanced modeling, although they offer valuable insights on relevant parameter combinations.
Performance of textured foil journal bearing considering the influence of relative texture depth

Both foil structure and surface texturing have been widely used to improve bearing performance. However, there is little research on their combination, namely, textured gas foil bearing. This paper adopts the Reynolds equation as the pressure governing equation of bump-type foil journal bearing to study the influence of textures located on the top foil. The Newton-Raphson iterative method and the perturbation method are employed to obtain static and dynamic characteristics, respectively. Thereafter, based on three texture distribution types, further analysis about the effect of the relative texture depth and the textured portion is carried out. The results indicate that an appropriate arrangement of textures could improve the performance of gas foil bearing. For #1 texture distribution, the maximum increment of load capacity could exceed 10% when ω = 1.4 × 105 r/min, ε = 0.2.
Allergen Immunotherapy: Current and Future Trends

Allergen immunotherapy (AIT) is the sole disease-modifying treatment for allergic rhinitis; it prevents rhinitis from progressing to asthma and lowers medication use. AIT against mites, insect venom, and certain kinds of pollen is effective. The mechanism of action of AIT is based on inducing immunological tolerance characterized by increased IL-10, TGF-β, and IgG4 levels and Treg cell counts. However, AIT requires prolonged schemes of administration and is sometimes associated with adverse reactions. Over the last decade, novel forms of AIT have been developed, focused on better allergen identification, structural modifications to preserve epitopes for B or T cells, post-traductional alteration through chemical processes, and the addition of adjuvants. These modified allergens induce clinical-immunological effects similar to those mentioned above, increasing the tolerance to other related allergens but with fewer side effects. Clinical studies have shown that molecular AIT is efficient in treating grass and birch allergies. This article reviews the possibility of a new AIT to improve the treatment of allergic illness.
Investigating Business Potential and Users’ Acceptance of Circular Economy: A Survey and an Evaluation Model

Circular economy is gaining attention in business and society to advance sustainability. This paradigm is particularly relevant for energy-consuming products such as washing machines, where alternatives to linear economy such as pay-per-use and refurbishment are gaining ground. To succeed, these business models should achieve consensus and acceptance among users. However, little attention has been paid to customers’ interest for circular economy business models so far. This paper aims to compare the economic and environmental impacts of pay-per wash and refurbishment business models, while investigating the degree of users’ acceptance and factors influencing it. A survey has been designed to collect users’ data regarding washing machine consumption patterns and acceptance rates of the circular business models. An evaluation model was developed to assess the economic and environmental impacts of pay-per-wash and refurbishment against a traditional linear model, fed with data from 279 Italian households collected through the survey. Finally, logistic regressions were carried out to investigate the influence of different customer, product, and usage factors on the acceptance rates of the two circular business models. Results show that, on average, pay-per-wash business models and washing machine refurbishment can guarantee environmental savings. However, only refurbishment generates economic savings for users. Moreover, only around half of the users’ sample shows a positive degree of acceptance of such alternatives. Respondent age has been found as a significant factor influencing the interest towards a refurbishment model, while the washing machine failures experienced by users and the relevance of the environmental gains achievable influence the acceptance rate of pay-per-wash models. Thus, when offering pay-per-wash schemes, suppliers should emphasize the information on the environmental benefits of this alternative, and that with such models they take over the responsibility and costs for maintenance and repair. On the other hand, providers of refurbished products should target younger consumers, who are less affected by a bias against second-hand goods.
Heavy Metal Contamination in Oryza sativa L. at the Eastern Region of Malaysia and Its Risk Assessment

Paddy plants tend to accumulate heavy metals from both natural and anthropogenic sources, and this poses adverse risks to human health. The objective of this study was to investigate heavy metal contamination in paddy plants in Kelantan, Malaysia, and its health risk assessment. The bioaccumulation of heavy metals was studied by means of enrichment (EF) and translocation factors (TF). The health risk assessment was performed based on USEPA guidelines. The EF for heavy metals in the studied areas was in the descending order of Cu > As > Cr > Cd > Pb. Meanwhile, Cr and Pb exhibited higher TF values from stem to grain compared with the others. The combined hazard index (HI) resulting from five heavy metals exceeded the acceptable limit (HI >1). The lifetime cancer risk, in both adult and children, was beyond the acceptable limit (10−4) and mainly resulted from exposure. The total cancer risk (CRt) due to simultaneous exposures to multiple carcinogenic elements also exceeded 10−4. In conclusion, intake of heavy metal through rice ingestion is likely to cause both non-carcinogenic and carcinogenic health risks. Further research is required to investigate the extent of heavy metal contamination in agricultural soils and, moreover, to establish human exposure as a result of rice consumption.
Determining factors in MSMEs success: An empirical study in Mexico

This work empirically analyzes the competitive factors that help make micro, small, and medium enterprises (MSMEs) successful. To do this, an empirical study with a sample of 614 companies in Guanajuato, Mexico, has been carried out. The results of the binary logistic regression analysis show that quality, technology, and innovation are the main variables that determine a company’s success. These findings could provide guidelines to help MSMEs improve their competitiveness, and they could help public administrations better support MSME growth.
Potential Impact of Biostimulator NeOsol and Three Different Manure Types on Physical Soil Properties and Crop Status in Heavy Soils Conditions

This study was conducted to understand the long-term influence of biostimulator NeOsol in combination with different manure types on soil’s physical properties and crop status. NeOsol is a soil biostimulator that should stimulate the biological reactions of the soil profile and improve the soil’s physical and chemical properties. A six-year experiment was conducted with eight treatments: NPK, cattle manure, pig manure, poultry manure, and the same four treatments with the NeOsol added on top. The in situ sampling of soil properties provided data on unit draft (UD), bulk density (BD), and saturated hydraulic conductivity (SHC). Furthermore, remotely sensed data were analyzed to describe crop status via three selected vegetation indices (VI), and crop yields were assessed last. The variants treated with NeOsol demonstrated decreases in UD over time; BD, SHC, and VI did not significantly change. The impact on yield was significant and increased over time. When comparing the variants with manure application to those without one, the cattle manure led to significantly higher SHC; the pig manure led to significantly lower UD and BD but significantly higher SHC and yield; and the poultry manure led to significantly lower UD and BD but higher yield.
Study on the Reliability and Accuracy of Scolioscope, a New Digital Scoliometer

Early detection of scoliosis with school screening and quick, easy, and reliable assessment of its progress are of paramount importance in the management of patients. There have been several tools described, with the most common being the analog scoliometer. Most recently, smartphone applications have entered this area with and without the use of sleeves for the device. There is no research that has evaluated the accuracy of measurements both left and right in either digital or analog devices. In this study, we evaluated the reliability and validity of a new digital scoliometer called the Scolioscope. Thirty subjects were included for the intra-rater reliability study. ICC values >0.9 were calculated both for same-day and between-day measurements. The device was highly accurate with an average difference from the ones set on the sine bar of 0.03° for right-side measurements and 0.18° for the left. These measurements suggest a highly accurate and reliable tool.
Heterogeneous Response of Airway Eosinophilia to Anti-IL-5 Biologics in Severe Asthma Patients

Many questions concerning responders (R) and nonresponders (NR) in severe eosinophilic asthma (SEA) after blocking the IL-5 (interleukin 5) pathway are still not clear, especially regarding the early parameters of response to biologics in personalized treatment strategies. We evaluated 17 SEA patients treated with anti-IL-5 biologics (16 patients mepolizumab, one patient benralizumab) before the introduction of biologics, and at a week 16 follow-up. Clinical, cellular and immunological parameters in peripheral blood were measured in R and NR. Sputum induction with the measurement of cellular and immunological parameters was performed at 16 weeks only. There were 12 R and 5 NR to biologics. After 16 weeks, there was a significant improvement in percentages of FEV1 (p = 0.001), and asthma control test (ACT) (p = 0.001) in the R group, but not in NR. After 16 weeks, the eosinophils in induced sputum were 27.0% in NR and 4.5% in R (p = 0.05), with no difference in IL-5 concentrations (p = 0.743). Peripheral eosinophilia decreased significantly in NR (p = 0.032) and R (p = 0.002). In patients with SEA on anti-IL-5 therapy, there was a marked difference in airway eosinophilic inflammation between R and NR already at 16 weeks, after anti-IL-5 introduction.
Effect of Probiotics on the Performance and Intestinal Health of Broiler Chickens Infected with Eimeria tenella

Coccidiosis is an important parasitic disease of poultry with great economic importance. Due to drug resistance issues, the study was conducted to investigate how probiotics (Lactobacillus plantarum or L. plantarum) affected oocysts per gram of feces (OPG), fecal scores, feed conversion ratio (FCR), immunomodulatory effect in terms of the cell-mediated and humoral immune response. Serum chemistry (ALT, AST, LDH, and creatinine) was measured in different treated chicken groups. mRNA expression levels of antioxidant enzymes (SOD 1 and CAT), peptide transporter 1 (PepT 1), and tight junction proteins (ZO and CLDN 1) were also examined in chicken groups infected with Eimeria tenella (E. tenella). Chickens supplemented with L. plantarum 1 × 108 CFU (colony-forming unit) showed an improved cell-mediated and humoral immune response, compared with the control group (p < 0.05). Probiotics also enhanced the performance of antioxidant enzymes, PepT 1, and tight junction proteins, and improved serum chemistry (AST, ALT, and LDH), compared with control-infected, non-medicated chickens. However, no significant difference (p > 0.05) was observed in CLDN 1 expression level and creatinine in all treated chicken groups. These findings demonstrated that probiotics supplementation in the feed can protect the birds against E. tenella infection.