Miracle-dz/UniFAR-FTUs huggingface dataset:
Nanoemulsion-Based Hydrogels and Organogels Containing Propolis and Dexpanthenol: Preparation, Characterization, and Comparative Evaluation of Stability, Antimicrobial, and Cytotoxic Properties

Recently, nanoemulsion-based gels have become very popular for dermal drug delivery, overcoming the disadvantages of conventional semi-solid drug forms. The aim of this study is to prepare and characterize nanoemulsion-based hydrogels and organogels containing combined propolis and dexpanthenol, and to compare their stability, antimicrobial, and cytotoxicity properties. Within the scope of characterization studies, organoleptic properties, drug content, morphology, pH, gel-sol conversion temperature, spreadability, viscosity, FT-IR, and release properties were evaluated in hydrogels and organogels. The characterization studies carried out were subjected to short-term stability evaluation at room temperature and refrigerator for 3 months. While no phase separation was observed in any of the formulations kept in the refrigerator, phase separation was observed in four formulations kept at room temperature. The release study successfully obtained an extended release for propolis and dexpanthenol. In the antimicrobial susceptibility study, Hydrogel 1 showed activity against S. aureus, while Organogel 1 showed activity against both S. aureus and S. epidermidis. In the cytotoxicity study against HDFa cells, both Hydrogel 1 and Organogel 1 were found to be nontoxic at low doses. These hydrogels and organogels, which contain propolis and dexpanthenol in combination for the first time, are promising systems that can be used in wound and burn models in the future.
Cyclic by prime fixed point free action

Let the ﬁnite group A be acting on a (solvable) group G and suppose that no non-trivial element of G is ﬁxed under the action of all the elements of A . Assume furthermore that ( | A | , | G | ) = 1. A long standing conjecture is that then the Fitting height of G is bounded by the length of the longest chain of subgroups of A . Even though this conjecture is known to hold for large classes of groups A , it is still unknown for some relatively uncomplicated groups. In the present paper we prove the conjecture for all ﬁnite groups A that have a normal cyclic subgroup of square free order and prime index. Since many of these groups have natural modules where they act faithfully and coprimely but without regular orbits, the result is new for many of the groups we consider.
Cold‐water coral ecosystems under future ocean change: Live coral performance vs. framework dissolution and bioerosion

Physiological sensitivity of cold‐water corals to ocean change is far less understood than of tropical corals and very little is known about the impacts of ocean acidification and warming on degradative processes of dead coral framework. In a 13‐month laboratory experiment, we examined the interactive effects of gradually increasing temperature and pCO2 levels on survival, growth, and respiration of two prominent color morphotypes (colormorphs) of the framework‐forming cold‐water coral Lophelia pertusa, as well as bioerosion and dissolution of dead framework. Calcification rates tended to increase with warming, showing temperature optima at ~ 14°C (white colormorph) and 10–12°C (orange colormorph) and decreased with increasing pCO2. Net dissolution occurred at aragonite undersaturation (ΩAr < 1) at ~ 1000 μatm pCO2. Under combined warming and acidification, the negative effects of acidification on growth were initially mitigated, but at ~ 1600 μatm dissolution prevailed. Respiration rates increased with warming, more strongly in orange corals, while acidification slightly suppressed respiration. Calcification and respiration rates as well as polyp mortality were consistently higher in orange corals. Mortality increased considerably at 14–15°C in both colormorphs. Bioerosion/dissolution of dead framework was not affected by warming alone but was significantly enhanced by acidification. While live corals may cope with intermediate levels of elevated pCO2 and temperature, long‐term impacts beyond levels projected for the end of this century will likely lead to skeletal dissolution and increased mortality. Our findings further suggest that acidification causes accelerated degradation of dead framework even at aragonite saturated conditions, which will eventually compromise the structural integrity of cold‐water coral reefs.
Self-organization in online collaborative work settings

As the volume and complexity of distributed online work increases, collaboration among people who have never worked together in the past is becoming increasingly necessary. Recent research has proposed algorithms to maximize the performance of online collaborations by grouping workers in a top-down fashion and according to a set of predefined decision criteria. This approach often means that workers have little say in the collaboration formation process. Depriving users of control over whom they will work with can stifle creativity and initiative-taking, increase psychological discomfort, and, overall, result in less-than-optimal collaboration results—especially when the task concerned is open-ended, creative, and complex. In this work, we propose an alternative model, called Self-Organizing Pairs (SOPs), which relies on the crowd of online workers themselves to organize into effective work dyads. Supported but not guided by an algorithm, SOPs are a new human-centered computational structure, which enables participants to control, correct, and guide the output of their collaboration as a collective. Experimental results, comparing SOPs to two benchmarks that do not allow user agency, and on an iterative task of fictional story writing, reveal that participants in the SOPs condition produce creative outcomes of higher quality, and report higher satisfaction with their collaboration. Finally, we find that similarly to machine learning-based self-organization, human SOPs exhibit emergent collective properties, including the presence of an objective function and the tendency to form more distinct clusters of compatible collaborators.
The Impact of Gas Flaring on Child Health in Nigeria

The Policy Research Working Paper Series disseminates the findings of work in progress to encourage the exchange of ideas about development issues. An objective of the series is to get the findings out quickly, even if the presentations are less than fully polished. The papers carry the names of the authors and should be cited accordingly. The findings, interpretations, and conclusions expressed in this paper are entirely those of the authors. They do not necessarily represent the views of the International Bank for Reconstruction and Development/World Bank and its affiliated organizations, or those of the Executive Directors of the World Bank or the governments they represent.
Secure and Lightweight Data Aggregation Scheme for Anonymous Multi-Receivers in WBAN

Wireless body area networks (WBANs) provide healthcare providers with early warning of medical emergencies by monitoring vital parameters of a patient's body with wearable devices embedded with biosensors. However, the resource-constrained nature of WBAN devices makes the data collected from them vulnerable to internal and external attacks during transmission. By aggregating medical data, data aggregation technology is used to conduct statistical analysis of the data and achieve confidentiality of patient information, which can help doctors make the correct diagnosis and assist medical insurance companies choose the right insurance for patients. However, the existing data aggregation schemes are inefficient or prone to potential safety risks to patients due to their high computational intensity and known identity of recipients. To address it, we propose a privacy-preserving health data aggregation scheme in the multi-receiver setting, which not only securely collects health data from IoT wearable devices but also supports the anonymity of multiple receivers while avoiding time-consuming pairing operations. Since the patient's health data and the recipient's identities are transmitted in cipher-text, it effectively prevents data leakage and achieves privacy protection of identity information among recipients. Compared with several existing schemes, the proposed scheme not only achieves anonymity of the collected data and the receivers' identities,but also makes it lightweight. Furthermore, experimental results demonstrate that the proposed scheme is cost-efficient in an all-around performance.
Comparison of the Gut Microbiome between Atopic and Healthy Dogs—Preliminary Data

Simple Summary Atopic dermatitis is a common inflammatory and itchy skin disease, constituting a global issue that affects up to 15% of the general human and dog population. The pathogenesis of this disease is known to be multifactorial and not only consisting of skin barrier dysfunction, but also with immunological dysregulation and skin microbiota changes having a central role. In humans, establishment of the gut microbiota in early life influences the development of allergies, among others also atopic dermatitis in children. To the author’s knowledge, there is currently no study comparing the gut microbiome between allergic and healthy dogs. We now present results demonstrating that allergic dogs have a significantly different gut microbiota when compared to healthy control dogs. Further investigations including a larger number of dogs are now required to confirm these results, in addition to studies utilizing novel interventions targeting the gut microbiota. Abstract Human studies show that in addition to skin barrier and immune cell dysfunction, both the cutaneous and the gut microbiota can influence the pathogenesis of atopic diseases. There is currently no data on the gut-skin axis in allergic canines. Therefore, the aim of this study was to assess the bacterial diversity and composition of the gut microbiome in dogs with atopic dermatitis (AD). Stool samples from adult beagle dogs (n = 3) with spontaneous AD and a healthy control group (n = 4) were collected at Days 0 and 30. After the first sampling, allergic dogs were orally dosed on a daily basis with oclacitinib for 30 days, and then re-sampled. Sequencing of the V3–V4 region of the 16S rRNA gene was performed on the Illumina MiSeq platform and the data were analyzed using QIIME2. The atopic dogs had a significantly lower gut microbiota alpha-diversity than healthy dogs (p = 0.033). In healthy dogs, a higher abundance of the families Lachnospiraceae (p = 0.0006), Anaerovoracaceae (p = 0.006) and Oscillospiraceae (p = 0.021) and genera Lachnospira (p = 0.022), Ruminococcus torques group (p = 0.0001), Fusobacterium (p = 0.022) and Fecalibacterium (p = 0.045) was seen, when compared to allergic dogs. The abundance of Conchiformibius (p = 0.01), Catenibacterium spp. (p = 0.007), Ruminococcus gnavus group (p = 0.0574) and Megamonas (p = 0.0102) were higher in allergic dogs. The differences in alpha-diversity and on the compositional level remained the same after 1 month, adding to the robustness of the data. Additionally, we could also show that a 4-week treatment course with oclacitinib was not associated with changes in the gut microbiota diversity and composition in atopic dogs. This study suggests that alterations in the gut microbiota diversity and composition may be associated with canine AD. Large-scale studies preferably associated to a multi-omics approach and interventions targeting the gut microbiota are needed to confirm these results.
Task-modality effects on young learners’ language-related episodes in collaborative dialogue

In adult learners’ collaborative dialogue, oral+written tasks have been found to promote a greater incidence and resolution of language-related episodes and to demand higher levels of accuracy than oral tasks thanks to the extra time learners have to reflect on their written outcome. No previous studies have tested whether asking learners to attend to accuracy in both modalities would yield similar results. The present study with 23 dyads of young English learners supports the superiority of the oral+written modality in the promotion of learning opportunities, even if learners are encouraged to focus on form in the oral modality, a result reinforced by the incorporation of target-like resolved episodes in the written product. However, the intragroup analysis reveals that young learners focus on meaning in equal terms, present low rates of target-likeness, and do not elaborate their resolutions, all of which can be ascribed to their younger age and developing metalinguistic awareness.
Does Childhood Experience of Interparental Abuse Shape Women’s Attitude Toward Intimate Partner Violence in Their Adult Life? Evidence From 31 Developing Countries

A significant amount of literature exists on the lasting effects of interparental abuse on children’s psychological health as adults. However, evidence on how children’s childhood experience of interparental violence shapes their attitude toward partner violence in adult intimate relationships is limited. Given the existing evidence that women’s acceptance of partner violence as a social norm increases the risk of partner violence, we analyzed the effect of girls’ witnessing interparental abuse (where a father is a perpetrator) on their attitude toward partner violence in their intimate relationships as adults. We used data from the Demographic and Health Surveys for 31 low and middle-income countries in Asia and Africa. Aggregating information about women’s attitudes toward partner violence into a binary “intimate partner violence acceptance” variable, we found that a woman who witnessed her father beat her mother was 1.62 times more likely to justify partner violence than a woman who did not experience such interparental abuse (adjusted odds ratio [AOR] = 1.62, 95% CI [1.57, 1.66], p < .001). Additionally, using individual components of acceptance as response variables, we found that a woman who witnessed interparental abuse was significantly more likely to justify partner violence if she went out without telling her husband (OR = 1.49, 95% CI [1.45, 1.54], p < .001), neglected children (OR = 1.53, 95% CI [1.49, 1.58], p < .001), argued with the husband (OR = 1.49, 95% CI [1.45, 1.53], p < .001), refused sex with the husband (OR = 1.35, 95% CI [1.31, 1.39], p < .001), or burned food (OR = 1.36, 95% CI [1.31, 1.41], p < .001). This study highlights the need to put in place children-specific social policies to limit the intergenerational transmission of the adverse effects of intimate partner violence.
Amniotic membrane/silk fibroin-alginate nanofibrous scaffolds containing Cu-based metal organic framework for wound dressing

Abstract Due to the skin’s critical role in protecting the body from external injury, substantial research has been performed to improve abnormalities, such as cuts or burns. Today, many wound dressings are manufactured in various forms, each with distinct features. Due to their biocompatibility and biodegradability, biopolymer nanofibers like Silk Fibroin and Sodium Alginate are viable options for wound dressings. In the present study, a hybrid scaffold with Sodium Alginate and Silk Fibroin biopolymers was fabricated via hybrid electrospinning on a decellularized human Amniotic membrane (hAM) to treat chronic wounds. A Copper-based metal-organic framework was employed to protect the wound area against Escherichia coli and Staphylococcus aureus (two common micro-organisms available in the wound area), which was evaluated using the dilution method (colony count), and a reduction in the presence of bacteria was detected. Additionally, Mesenchymal stem cell viability was seen due to the addition of Cu-MOF. Furthermore, hAM boosted the adhesion and proliferation of Mesenchymal Stem Cells in prepared scaffolds and increased water wettability, which is critical during the wound healing process. These findings indicate that nanofibers containing Cu-based MOFs are promising materials for biomedical applications.
Methods of the Large-Scale Production of Extracellular Vesicles

To date, extracellular vesicles (EVs) have been extensively investigated as potential substitutes for cell therapy. Research has suggested their ability to overcome serious risks associated with the application of these cells. Although, the translation of EVs into clinical practice is hampered by the lack of a cheap reasonable way to obtain a clinically relevant number of EVs, an available method for the large-scale production of EVs ensures vesicles’ integrity, preserves their biological activity, and ensures they are well reproducible, providing homogeneity of the product from batch to batch. In this review, advances in the development of methods to increase EVs production are discussed. The existing approaches can be divided into the following: (1) those based on increasing the production of natural EVs by creating and using high capacity “cell factories”, (2) those based on the induction of EVs secretion under various cell stressors, and (3) those based on cell fragmentation with the creation of biomimetic vesicles. The aim of this review is to stimulate the introduction of EVs into clinical practice and to draw attention to the development of new methods of EVs production on a large scale.
ASAP2: an improved batch means procedure for simulation output analysis

We introduce ASAP2, an improved variant of the batch-means algorithm ASAP for steady-state simulation output analysis. ASAP2 operates as follows: the batch size is progressively increased until the batch means pass the Shapiro-Wilk test for multivariate normality; and then ASAP2 delivers a correlation-adjusted confidence interval. The latter adjustment is based on an inverted Cornish-Fisher expansion for the classical batch means t-ratio, where the terms of the expansion are estimated via a first-order autoregressive time series model of the batch means. ASAP2 is a sequential procedure designed to deliver a confidence interval that satisfies a prespecified absolute or relative precision requirement. When used in this way, ASAP2 compares favorably to ASAP and the well-known procedures ABATCH and LBATCH with respect to close conformance to the precision requirement as well as coverage probability and mean and variance of the half-length of the final confidence interval.
Climate-Smart Agriculture in African Countries: A Review of Strategies and Impacts on Smallholder Farmers

The agricultural sector contributes approximately 10–20% of the total anthropogenic greenhouse gas (GHGs) emissions. Consequently, climate change can negatively affect crop yields and livestock production thus threatening food security, especially in a vulnerable continent like Africa. This review provides an overview of climate-smart agriculture (CSA) practices and their impacts on smallholder farmers in five African countries (Algeria, Senegal, Benin, Nigeria and Zambia). A total of 164 published articles on CSA practices were reviewed. Analysis of extracted data showed that CSA practices are classified as follows: agricultural practices, restoration practices of degraded lands, forest and cropland regeneration practices, practices in the livestock sub-sector, water resources and use of weather and climate information services. Moreover, climate change effects differed alongside strategies adapted from one country to another. Adoption of these strategies was often influenced by financial means put in place by governments, the role of policy legislation, access to climate information and farmers’ intellectual level. To address this deficiency, scientific-outcome-based research should be used to increase the effectiveness of climate adaptation management programs. In conclusion, to enhance the uptake of climate-smart agricultural practices in Africa, this review recommends the use of scientific-research-driven adaptation measures and prioritization of climate change in governments’ agendas.
Comparison of Muscle Regeneration after BMSC-Conditioned Medium, Syngeneic, or Allogeneic BMSC Injection

For many years optimal treatment for dysfunctional skeletal muscle characterized, for example, by impaired or limited regeneration, has been searched. Among the crucial factors enabling its development is finding the appropriate source of cells, which could participate in tissue reconstruction or serve as an immunomodulating agent (limiting immune response as well as fibrosis, that is, connective tissue formation), after transplantation to regenerating muscles. MSCs, including those derived from bone marrow, are considered for such applications in terms of their immunomodulatory properties, as their naive myogenic potential is rather limited. Injection of autologous (syngeneic) or allogeneic BMSCs has been or is currently being tested and compared in many potential clinical treatments. In the present study, we verified which approach, that is, the transplantation of either syngeneic or allogeneic BMSCs or the injection of BMSC-conditioned medium, would be the most beneficial for skeletal muscle regeneration. To properly assess the influence of the tested treatments on the inflammation, the experiments were carried out using immunocompetent mice, which allowed us to observe immune response. Combined analysis of muscle histology, immune cell infiltration, and levels of selected chemokines, cytokines, and growth factors important for muscle regeneration, showed that muscle injection with BMSC-conditioned medium is the most beneficial strategy, as it resulted in reduced inflammation and fibrosis development, together with enhanced new fiber formation, which may be related to, i.e., elevated level of IGF-1. In contrast, transplantation of allogeneic BMSCs to injured muscles resulted in a visible increase in the immune response, which hindered regeneration by promoting connective tissue formation. In comparison, syngeneic BMSC injection, although not detrimental to muscle regeneration, did not result in such significant improvement as CM injection.