Miracle-dz/UniFAR-FTUs huggingface dataset:
Reply to: Mild Chronic Colitis Triggers Parkinsonism in LRRK2 Mutant Mice through Activating TNF‐α Pathway

We are pleased to know that LRRK2 expression is not limited to immune cells in the lamina propria but is also observed in enteric neurons of the submucosal and myenteric plexus of gastrointestinal tracts, as described by Maekawa et al. In our recently published study, human colonic tissues were sampled by routine biopsy, which was usually shallow to the level of the submucosal layer, and rarely to the muscular level. Therefore, the LRRK2 expression observed in our routine colonic biopsies was mainly in the lamina propria and did not cover either the submucosal or myenteric plexus. Notably, in our study, most of the colonic biopsies were performed in the transverse or descending colon as part of the follow-up for colonic polyps in a limited patient sample. We did not have sigmoid colonic biopsy samples, as Derkinderen et al showed in their letter to the editor and their recent study. Since the innervation system differs between the descending colon and sigmoid, we hypothesize that LRRK2 expression may not be evenly distributed throughout the gastrointestinal tract. Further studies, enrolling more participants with multiple biopsies from different regions of the gastrointestinal tract, are needed to elucidate the distribution of LRRK2 in the gut. We agree with Derkinderen and colleagues that additional investigations are needed to delineate the role of LRRK2 in the enteric nervous system—including studies using multiplex immunohistochemistry/immunofluorescence staining to determine the specific localization of LRRK2 in individual cell types, such as ChAT-positive, VIP-secreting neurons, sympathetic TH-positive neurons, and enteric glia. Furthermore, as we have addressed, LRRK2 G2385R is a polymorphism that may cause a partial loss-of-function mutation instead of increasing LRRK2 kinase activity. Our findings from transgenic LRRK2 G2019S mice should be verified by a large cohort study enrolling patients with the LRRK2 G2019S mutation. Finally, we agree with Derkinderen and colleagues that it is insufficient to measure total LRRK2 expression level, and necessary to also examine the levels of phospho-LRRK2 and its substrates, such as phospho-Rab10. However, phosphorylated proteins are liable to lose their antigenicity in paraffin-embedded tissue samples. One study demonstrates that several phosphorylated proteins, including phospho-AKT, phosphor-ERK1/2, and phospho-tyrosine, lost their antigenicity within 2 hours of cold ischemic time during tissue preparation for the paraffin-embedding process. Therefore, the expression of phospho-LRRK2 in paraffinembedded biopsied colonic tissues should be cautiously interpreted. Future prospective studies, in which fresh biopsied gut tissues are collected in a follow-up study design, are needed to elucidate LRRK2 expression and activity in the gastrointestinal tract during the Parkinson’s disease process.
Numerical Analysis of Flow Field in Shell Side of Cinquefoil Orifice-Baffle Support Type Heat Exchanger

A simplified model of the Cinquefoil orifice-baffle supported type heat exchanger has been presented.By using those simplification method and FLUENT program,the heat exchanger was analysed numerically.The required information for knowing condition of fluid flow and heat transfer were obtained.The correspond fitting formudlas by the numerical simulation of different span orifice-baffle were given.These formulas provided the basis for designing exchangers.
Swing characteristic of pads in tilting pad bearing

The geometric relations of pad on tilting-pad bearing were studied,the relationship between tile pendulum angle and structural parameters were established by the oil-film force model of finite length tilting pad bearing and equilibrium equation,and the basic law of tile pendulum angle change was analyzed.The study shows that the tile pendulum angle is determined by the pad structural parameters,the eccentricity ratio of tilting pad bearing and the clearance ratio,but independent of shaft rotating speed,viscosity of lubrication oil,etc.A case study of a tilting pad bearing with 80 deg pad arc angle,0.5 offset was performed to illustrate the law of tile pendulum angle varies with eccentricity ratio and clearance ratio.It is revealed that,when the structural parameters of tilting pad bearing are constant,the tile pendulum angle increases first and then decreases with the original eccentricity ratio increases,and increases linearly with the increasing of bearing clearance ratio.
Sorption properties of activated carbons for the capture of methyl iodide in the context of nuclear industry

In the present study, some commercially available activated carbons were evaluated towards the methyl iodide (CH3 I ) capture in the context of nuclear industry. A specific methodology was implemented in order to establish structure-activity relationships between adsorbent characteristics and its adsorption behavior towards CH i I. On the one hand, the investigated adsorbents were characterized by a combina­ tion of physico-chemical techniques. On the other hand, CH i I retention performance from batch sorp­ tion tests under different conditions (temperature and relative humidity) was studied using an original experimental setup. In this work, two conditions were investigated: (i) T = 35°C, R.H. = 26 % ([H2 O] ~15,000 ppmv); (ii) T = 75°C, R.H. = 30 % ([H i O] ~130,000 ppmv). Different trends were obtained depending on the investigated scenario. At ambient conditions (i), CH3 I adsorption performance was af- fected after KI/TEDA impregnation because of partial pore blockage phenomena induced by the of im-pregnants presence within the microporosity. However, TEDA impregnation was found to be required to enhance the trapping stability and to capture CH i I with superior efficiency at higher temperature (ii).
Free Flap Outcome in Irradiated Recipient Sites: A Systematic Review and Meta-analysis

Background: The impact of previous radiotherapy on free flap outcome is still a subject of debate. Clinical investigations have come to divergent conclusions and the true effect of radiotherapy (XRT) on flap survival is not definitely known. Most studies investigating the factor often have their methodological limitations such as lack of statistical power as a consequence of the overall low failure rates together with few irradiated cases. This study will attempt to address the question whether previous radiotherapy is associated with a significantly higher incidence of flap failure or not. Methods: A systematic review and meta-analysis were conducted in concordance with the PRISMA protocol using the PubMed database. Fixed-effect and random-effect models were applied to obtain the odds ratio of total flap failure and partial flap failure between radiation and nonradiation groups. Statistical heterogeneity and publication bias were assessed and forest plots and funnel plots were constructed for graphic illustration. Results: A total of 43 studies were included for qualitative and quantitative analysis involving 18,776 flaps in 17,532 patients. Patients with preoperative XRT were significantly associated with an increased risk for total (odds ratio fixed = 1.675, 95% confidence interval [CI] = 1.405–1.996, P < 0.001) and partial free flap failure (odds ratio fixed = 2.161, 95% CI = 1.472–2.172, P < 0.001). Conclusion: The study suggests that preoperative radiotherapy is associated with an increased risk for total and partial free flap failure. Further studies are needed to investigate the effect of total XRT dose and time after radiation on free flap outcome.
Histopathological findings in laparoscopic sleeve gastrectomy specimens: Are pathological examinations necessary?

Objective: The objective of this study is to determine the prevalence of gastric histopathological findings in patients who underwent laparoscopic sleeve gastrectomy (LSG) in our hospital and to add more data to the published literature on the characteristics of the resected LSG samples. Material and Methods: The pathology reports of the patients were retrospectively analyzed to identify all patients with consecutive morbidly obesity who underwent LSG from January 2015 to December 2019. All patients underwent gastroscopy in the preoperative period. Results: The study analyzed 800 patient reports. No specific pathological finding was observed in 230/800 (28.75%) of the patients, which was reported as normal. Specific pathological findings were present in 570 (71.25%) patients. Cases of chronic inactive gastritis (400 patients [50%] ), chronic active gastritis (134 patients [16.7%] ), intestinal metaplasia (2 patients [0.2%] ), low-grade dysplasia (1 patient [0.12%] ), stromal tumor (7 patients [0.87%] ), Neuroendocrine (NE) cell hyperplasia (7 patients [0.87%] ), fundic gland polyps (3 patients [0.37%] ), granulomatous gastritis (1 patient [0.12%] ), acute gastritis (1 patient [0.12%] ) and ectopic pancreas (1 patient [0.12%] ) were recorded. Conclusion: Surgeons should be aware of the high unexpected histopathological prevalence in bariatric patients. Although our study did not find any malignant pathological result, we believe that routine postoperative pathological examination and preoperative endoscopy are necessary for medicolegal reasons.
The Impact of Environmental Variables on UAS-based Atmospheric Carbon Dioxide Measurements

Carbon Dioxide Measurements Gustavo B. H. de Azevedo*1,2, Bill Doyle2, Christopher A. Fiebrich3, and David Schvartzman1 1Advanced Radar Research Center (ARRC) at The University of Oklahoma 2Center for Autonomous Sensing and Sampling (CASS) at The University of Oklahoma 3Oklahoma Mesonet, Oklahoma Climatological Survey at The University of Oklahoma Correspondence: Gustavo B. H. de Azevedo (gust@ou.edu)
Faiza ELLOUMI 1

One of the research questions while waiting for a solution is to know the impact of venture capital on the performance of companies. In the case of a significant effect on added value and on the performance of companies, venture capital is said to be a very relevant mode of financing. In this regard we test whether there is a financial added value realized by the capital companies within innovative companies and we examine different determinants favoring financial performance. Mainly, we study whether the participation of venture capital leads to a significant increase in the performance of the company.
ONLINE TRAVEL PORTAL AND THEIR EFFECT ON TRAVEL AGENCY: A STUDY ON OUTBOUND VISITORS OF VARANASI

The internet revolution has changed the scenario of travel industry through the easily accessible of travel products to the mass consumers by their virtual presence rather than physical. The online travel Portal (OTP) is also known by Online Travel agent, E-travel agents and virtual travel agents (VTA’s). The concept of travel agents immersed as a connecting link between supplier and consumer. In a last 5-10 years techno friendly visitors prefer more to buy their travel services online like the online shopping of physical goods. The OTP has served vast prospects for travellers to buy their travel directly online thereby evading the traditional travel systems i.e. travel agencies. While serving as an intermediary means between service providers and tourists, internet has reduced the significance of the traditional intermediary (travel agents) or at the large extent traditional part became very uncommon in today's practice. Web-services may eventually progress to disintermediation of travel business since the travel facility and product suppliers can sell their products and services directly to the travellers. Yet, Traditional Travel agencies still have the benefit of serving personalized services particularly in giving advice to travellers with an individual touch. This paper attempts to examine perceptions of tourists travelling from eastern Uttar Pradesh who had not only used traditional methods but also booked their itinerary through at least one travel website and Web Portals which can relate their experience in using them and their opinion upon disintermediation. The study will determine preference of tourists in choosing their services in accordance to their length of stay, demographic and socio-economic characteristics upon their purchasing behaviour.
Text Mining of Twitter Data for Public Sentiment Analysis of Staple Foods Price Changes

— Millions of users share their opinions on twitter, making it valuable platform for tracking and analyzing public opinion. Such analysis can provide critical information for decision maker in various domains. In this study, we examine public sentiment analysis of staple foods price changes in Indonesia based on twitter data. Text mining was used for classifying tweets into positive and negative sentiment. Then association between the type of staple foods and sentiment classes were analyzed using Chi Square test and Marascuillo procedure. Results show that Support Vector Machine (SVM) classifier produce higher accuracy than Naïve Bayes and Decision Trees. Also, the price of milk, eggs and red onion had the most significant association to the negative sentiment compared to other commodities. 
Management of ADHD in Prisoners—Evidence Gaps and Reasons for Caution

Attention Deficit Hyperactivity Disorder (ADHD) is a neurodevelopmental disorder, estimated to affect 5–7% of children and adolescents worldwide [(1–3), though see (4, 5)]. ADHD was once thought to decline rapidly with age, with persistence into adulthood thought to be very uncommon (6). In the last two decades, thinking has shifted (7). While estimates for persistence into adulthood vary, more robust research studies suggest this is about 15% (8). Widely cited studies estimate the prevalence of adult ADHD in the general population to be 3–5% (9–11), with rates typically being higher for men, though concerns about overdiagnosis should be noted (5, 12–14). Increasing awareness and discussion about ADHD has led to development of several consensus and guidance documents internationally (15–21). In incarcerated populations, rates are thought to be disproportionately high (22), but underdiagnosed (23), leading to lobbying for prioritization of ADHD in prisons and calls for effective screening and treatment protocols (20–25). Increased recognition and treatment of ADHD in adult prisoners has several potential benefits, beyond improvements in subjective well-being. Firstly, for many patients, receiving a diagnosis of ADHD may be validating (26). It could feasibly allow prisoners to come to terms with their offending histories and accept input from mental health services, which may in turn identify other mental health problems. Secondly, if treatment proves effective, resolution of core symptoms of the condition may encourage attendance at educational, occupational and therapeutic activities (25), which can have broader clinical benefits (27). Thirdly, if links between ADHD symptomatology and problematic behaviors within prisons, especially violence, are shown to exist, effective treatments would reduce the burden of these behaviors on prisons. Finally, as effective treatments for the most common cause of aggression and violence in prisoners—antisocial personality disorder (ASPD)— are very limited (28, 29), reattribution of some antisocial behavior to ADHD may have benefits to staff in mental health settings, reducing the therapeutic nihilism that is associated with ASPD (30, 31). Efforts to improve outcomes for prisoners’ mental health and reduce violence and offending are welcome. However, there are several reasons for caution toward the emergent focus on ADHD, and several gaps in the evidence base that need to be addressed. Below, I outline these in turn, offering suggestions for a measured and empirical approach to the condition within holistic formulation and management in prison psychiatry settings.
Organizational support and turnover intention in the Spanish IT consultancy sector: Role of organizational commitment

Abstract This paper focuses on the IT consultancy sector, an area of strategic importance within the Spanish economy and its mains aim is to analyse the impact that the support perceived by employees has on their organizational commitment and turnover intention.We distributed a questionnaire with a five-point Likert scale among 1000 professionals from various companies in the IT consultancy sector in Spain. The data collected were analysed using the PLS-SEM (partial least squares structural equation modelling) technique with the SmartPLS software. The analysis of the data demonstrates a negative relationship between employees’ perception of organizational support and their turnover intention, i.e., the greater the organizational support received, the lower the intention to leave the company. In companies where employees had a higher degree of organizational commitment, their intention to leave the company decreased to an even greater extent.This study shows that both the organizational support perceived by employees and their organizational commitment are important factors that influence their turnover intention; therefore, organizations need to take these aspects into consideration to reduce staff turnover rates.
Big data analytics adoption via lenses of Technology Acceptance Model: empirical study of higher education

The goal of this study was to establish a model to quantify the adoption of big data in relation to education and to translate the adoption of big data in literature into the educational context. This study hypothesizes that encouraging situations, perceived risk, perceived usefulness, perceived ease of use influence the attitude of the students towards use and the intention to use behavior, in turn impacting the adoption of big data in education, this research used the Technology Acceptance Methodology (TAM) model. Through analyzing 282 university students, the present thesis followed quantitative data collection along with analysis procedures. Therefore, the responses of students were grouped into seven testing constructs and evaluated to understand their adoption influence. Accordingly, data were subsequently quantitatively analysed utilising Structure Equation Modelling (SEM). The findings revealed that facilitating conditions, perceived risk, perceived usefulness, perceived ease of use were important determinants of the attitude of students towards use and behavioral intention to use big data, and 71.2% of acceptance was also significant for the attitude of students towards use and behavioral intention to use big data
Investigation the Factors that Affect Intention to Use Informational Technology among Payame Noor University Students (English Language) at Fars Province

Abstract The purpose of this study is presenting path analysis model of intention to use technology among English language students in Fars Payame Noor University. Research methodology is co relational and the instrument for data collection, are standardized questionnaires that were analyzed with software Lisrel. The results show that computer self-efficacy (0.23), perceived ease of use (0.28) and perceived usefulness (0.23) have direct and significant effect with intention to use technology, computer self-efficacy (0.36), cognitive absorption (0.18) and perceived ease of use (0.22) have significant and direct effect with perceived usefulness, and finally computer self-efficacy (0.20) and cognitive absorption (0.25) have significant and direct effect with perceived ease of use.
Preexisting Type 1 Diabetes Mellitus Blunts the Development of Posttraumatic Osteoarthritis

Type 1 diabetes mellitus (T1DM) affects 9.5% of the population. T1DM is characterized by severe insulin deficiency that causes hyperglycemia and leads to several systemic effects. T1DM has been suggested as a risk factor for articular cartilage damage and loss, which could expedite the development of osteoarthritis (OA). OA represents a major public health challenge by affecting 300 million people globally, yet very little is known about the correlation between T1DM and OA. In addition, current studies that have looked at the interaction between diabetes mellitus and OA have reported conflicting results with some suggesting a positive correlation whereas others did not. In this study, we aimed to evaluate whether T1DM exacerbates the development of spontaneous OA or accelerates the progression of posttraumatic osteoarthritis (PTOA) after joint injury. Histological evaluation of T1DM and control joints determined that T1DM mice displayed cartilage degeneration measurements consistent with mild OA phenotypes. RNA sequencing analyses identified significantly upregulated genes in T1DM corresponding to matrix‐degrading enzymes known to promote cartilage matrix degradation, suggesting a role of these enzymes in OA development. Next, we assessed whether preexisting T1DM influences PTOA development subsequent to trauma. At 6 weeks post‐injury, T1DM injured joints displayed significantly less cartilage damage and joint degeneration than injured non‐diabetic joints, suggesting a significant delay in PTOA disease progression. At the single‐cell resolution, we identified increased number of cells expressing the chondrocyte markers Col2a1, Acan, and Cytl1 in the T1DM injured group. Our findings demonstrate that T1DM can be a risk factor for OA but not for PTOA. This study provides the first account of single‐cell resolution related to T1DM and the risk for OA and PTOA. © 2022 The Authors. JBMR Plus published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research.
Characteristics of The Citizen of the Future According to the Views of Pre-Service Social Studies Teachers

The present study aimed to allow pre-service social studies teachers to define the citizens of the future and to determine the characteristics of the citizens of the future according to pre-service social studies teachers. The study group included 19 pre-service social studies teachers attending Fırat University, Faculty of Education and participated in the study on a volunteer basis. Criterion sampling method was used in the study. Thus, a semi-structured interview form that included open-ended questions was utilized to interview the students. In the study, the data were analzyed with descriptive analysis. The study findings demonstrated that pre-service social studies teachers defined the citizens of the future as individuals who love their homeland, adhere to the state and national ideals, are educated, well-informed, and aware of their rights and responsibilities as active citizens. The characteristics of the citizens of the future were described as well-informed, concerned, research-oriented, prioritizing national unity and solidarity, respectful, honest, charitable, and educated by the students. According to the pre-service teachers, citizens of the future should not be insensitive and irresponsible, betray their homeland and be useful, should not be self-seeking and selfish, uninformed, uneducated, unaware.
Impact of COVID-19 on the Gastrointestinal Tract: A Clinical Review

Coronavirus disease 2019 (COVID-19) has spread rapidly throughout the world, causing a pandemic that has resulted in more than 5 million deaths globally. The gastrointestinal (GI) tract is known to have high expression of angiotensin-converting enzyme 2 (ACE2) receptors in the human body, making it prone to direct damage from the cellular invasion of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Numerous GI symptoms have been reported among patients with COVID-19. This systemic review details the mechanism and effects of COVID-19 on the GI tract along with the hepatobiliary and pancreatic systems.