Miracle-dz/UniFAR-FTUs huggingface dataset:
Destruction of secondary Schistosoma mansoni sporocysts in Biomphalaria glabrata after phytochemical exposure

Background: Schistosomiasis is a neglected tropical disease and affects over 200 million people worldwide. The snail Biomphalaria glabrata is one of the intermediate hosts of S. mansoni . The aim of this work was to verify the action of Euphorbia milii var. hislopii latex in the hemocytes profile and histopathology of B. glabrata infected by S. mansoni . Methods: Uninfected and infected snails were exposed to sublethal concentrations of E. milii latex for 24 hours (1.0 mg/l less than the LC 50 ) and after this time were analysed.Results: The survival rate was 88.5% for the uninfected snails and 66.6% for the infected and exposed snails. In the snails infected by S. mansoni , the exposure to E. milii latex promoted proliferation of hemocytes in the tentacles, mantle, digestive gland, kidney and ovotestis. In the digestive gland and the kidney, granulomatous reactions occurred around the sporocysts and caused their destruction. Proliferation of hemocytes in the kidney and digestive gland and edema in the mantle area were also observed in the uninfected and exposed snails. The number of circulating hemocytes from the group infected and exposed to E. milii latex was significantly higher than in the other groups. Three types of hemocytes were found: hyalinocytes, granulocytes and blast-like cells, and in all the groups the proportion of hyalinocytes was higher than the other types. There was no significant difference among the cell types and the different groups analyzed. Conclusions: We conclude that the sublethal concentration of E. milii latex influenced the cellular immune response of the susceptible B. glabrata strain to infection by S. mansoni , promoting the destruction of parasites.
What you sow is what you reap

What you sow is what you reap is the story of a woman whose behavior is blamed for her suffering in childbirth. It was told by Sunday John in a recording made in February 2013 in Tungan Magajiya, Niger State. It was transcribed in the orthography and translated into English by Sunday John into ParaTExt translation software. I time aligned the transcription/translation into ELAN and added IPA transcription.
COVID-19: An overview of current scenario

Over a span of few decades, the world has seen the emergence of new viruses that have posed serious problems to global health . COVID-19 is a major pathogenic threat to the modern world that primarily shoots the respiratory system of human beings. Wuhan which is the capital city of Hubei, China was the first place in the world where first cases of COVID-19 emerged and the scores of cases significantly increased at an immense rate leading to city isolation and establishment of new specially designed hospitals. SARS-CoV had emerged from bats in china (2002) and MERS-CoV from camels transmitted via bats in Middle East (2012) where the previous versions of COVID-19 took place. Infections with SARS-CoV-2 are now widespread, like Nuclear Chain Reaction (NRC). In this review we will discuss the COVID-19 origin, transmission, incubation, diagnosis and therapies available at the present scenario.
Should we keep some distance from distancing? Regulatory and post-regulatory effects of emotion downregulation

Emotion regulation is an indispensable part of mental health and adaptive behavior. Research into emotion regulation processes has largely focused on the concurrent effects of volitional emotion regulation. However, there is scarce evidence considering post-regulatory effects with regard to neural mechanisms and emotional experiences. Therefore, we compared concurrent effects of cognitive emotion regulation with effects at different (immediate, short- and long-term) time intervals. In an fMRI study with N = 46 (N = 30 at re-exposure) young healthy adults, we compared neuronal responses to negative and neutral pictures while participants had to distance themselves from or to actively permit emotions in response to these pictures. We investigated the temporal dynamics of activation changes related to regulation in cognitive control brain networks as well as in the amygdala during stimulation (concurrent effects, timepoint 1) and post-stimulation (immediate, timepoint 2), as well as during re-exposure with the same pictures after short (10 minutes, timepoint 3) and long (1 week, timepoint 4) time intervals. At timepoint 1, negative pictures (versus neutral pictures) elicited a strong response in regions of affective processing, including the amygdala. Distancing (as compared to permit) led to a decrease of this response, and to an increase of activation in the right middle frontal and inferior parietal cortex. We observed an interaction effect of time (stimulation vs. post-stimulation) and regulation (distance vs. permit), indicating a partial reversal of regulation effects during the post-stimulation phase (timepoint 2). Similarly, after 10 minutes (timepoint 3) and after 1 week (timepoint 4), activation in the amygdala was higher during pictures that participants were previously instructed to distance from as compared to permit. These results show that the temporal dynamics are highly variable both within experimental trials and across brain regions. This can even take the form of paradoxical aftereffects at immediate and persistent effects at prolonged time scales.
Optimization of culture conditions for squalene production and squalene extraction method of Thraustochytrium<\i> sp. TN22

Squalene, a natural triterpene with important roles as antioxidant, skin hydrating, cardio-protection and detoxifier, has attracted the attention of researchers in the world. This study investigated the optimal culture conditions for squalene production and to develop a method for squalene extraction and purification from cell suspension of Thraustochytrium sp. TN22. The results showed that squalene production by the strain Thraustochytrium sp. TN22 was optimum at 2% glucose, 0.5% yeast extract and 0,14% mixture of vitamins (B1, B6 and B12) at 28 oC for 2 days of cultivation. At the optimum conditions, the dry biomass, squalene content and productivity were approximately 9.3 g/L, 9.9 mg/g DCW and 95.3 mg/L, respectively. Time-dependence on cell lysis and extraction solvents were selected as the extraction parameters. The obtained results showed that the highest squalene production of 178.1 mg/100 g biomass was obtained in cell lysate at alkaline medium (pH = 10), at 60 oC for 6 hours and n-hexan was the best solvent for squalene extraction. Squalene was then purified on silica gel column using n-hexan as the mobile phase and 90% purity of squalene was archived. Our obtained results are promising for the commercial productions of various value-added compounds from species belong to the genus Thrautochytrium in Vietnam.
Linking Job Stress to Turnover Intention in Private Company: What is the Role of Leadership Style?

This research aims to measure the effect of leadership style on turnover intention of a private company in Indonesia mediated by job stress. Data collection was carried out by simple random sampling to 253 population. The returned and valid questionnaire results were 147 samples. Data processing was using SEM method with SmartPLS 3.0 software. The results of this research are leadership style has a negative and significant effect on job stress and turnover intention. Job stress has a positive and significant effect on turnover intention. Job stress was not a mediator for the relationship between leadership style and turnover intention. This novel research is proposing a model to manage turnover intention among employees of a private company in Indonesia through leadership practice with job stress management as mediation. This research can pave the way to improve teacher readiness in facing the industrial revolution 4.0.
Serious problems with interpreting rubber hand illusion experiments

The rubber hand illusion (RHI), in which participants report experiences of ownership over a fake hand, appears to demonstrate that subjective ownership over one’s body can be easily disrupted. In RHI, ownership is typically quantified through ratings of agreement with statements putatively about body ownership. It was recently shown that propensity to agree with these statements is correlated with trait phenomenological control (the ability to generate experience to meet expectancies arising from direct or indirect suggestion) and that existing methods of controlling for suggestion effects in RHI are invalid. Here, we present the results of simulated experiments that mimic standard practice in RHI studies, using real participant data. In each experiment the sample was biased in selection for trait phenomenological control. Using samples comprised of participants higher in trait phenomenological control almost guarantees that an experiment provides evidence for RHI. By contrast, samples comprised of only participants lower in trait phenomenological control find evidence for RHI only around half the time (and “ownership” experience just 4% of the time). It is therefore likely that existing RHI experiments have studied phenomenological control by proxy. Previous RHI studies cannot be used to make inferences about the sense of ownership in humans generally.
Comparison of the effect of Chamomile and Mefenamic Acid on primary dysmenorrhea, associated symptoms and menstrual bleeding – A randomized clinical trial study

Background Dysmenorrhea is one of the most common pelvic pains in women, impairing their quality of life.This study investigated the effects of chamomile sachet and mefenamic acid on primary dysmenorrhea, associated symptoms and bleeding. Methods In this randomized clinical trial, 200 female students with primary dysmenorrhea from Arak universities were randomly assigned to two groups. The group (A) received mefenamic acid (250 mg) and group (B) received chamomile (5000 mg) plus one teaspoonful of honey )as a flavoring( for two days before up to the first three days of menstruation, three times a day in two consecutive cycles. Pain severity, associated symptoms and bleeding were assessed using visual analog scale, Andersch-Milsom Verbal Scale and Higham chart, respectively. Data were analyzed by descriptive and inferential statistical tests by SPSS 21. Results Severe pain during two months after intervention was in 6 (6.3%) of group (B) and 6 (6.3%) in group (A) (p = 0.351, p = 0.332). Mean severity of associated symptoms two months after the treatment was( 4.93 ± 3.54) in group (B) and (5.62 ± 3.54 ) in group (A), indicating further reduction in group (B) but not significant (p = 0.278). Mean of bleeding was (88.71 ± 66.4 vs. 70.54 ± 53. 34) in group (B) and (A) respectively, in two months later. therefore decrease in the two groups but was not significant between groups(p = 0.567). Conclusions It seems chamomile sachet can reduce the severity of pain and bleeding similar to mefenamic acid and even further mitigate the symptoms associated with dysmenorrhea. Trial registration: This study was performed with the proposal approval code of 2611, ethics code of (ARAKMU.REC.1395.164) at Arak University of medical sciences and code of IRCT 2016100825031N5 on 2016.11. 08.
Mineral Fibres: Crystal Chemistry, Chemical-Physical Properties, Biological Interaction and Toxicity

The state of the art in the field of mineral fibres is illustrated and discussed here, with a multidisciplinary approach taking into account all the different scientific strands (biology, chemistry, epidemiology, mineralogy, physics, toxicology etc.). The different views have been considered in an attempt to assemble the pieces of the jigsaw and to present the reader with an up-to-date and complete picture.
Individual concerns modulate reward-related learning and behaviors involving sexual outcomes

Pavlovian and instrumental conditioning are fundamental processes helping organisms learn about stimuli that predict rewards in the environment and actions that lead to their obtainment. These two forms of learning and their interplay notably exert a strong impact on reward-seeking behaviors. Here, we examined in humans whether Pavlovian and instrumental learning along with their effects on cue-driven behaviors involving sexual rewards are modulated by the reward relevance to the individual’s sexual orientation. In two experiments, we manipulated the concern-relevance of sexual outcomes in a Pavlovian-instrumental transfer paradigm by recruiting heterosexual and homosexual men and selecting sexual stimuli for each sexual orientation. Results showed enhanced instrumental and Pavlovian learning in response to the most relevant sexual outcome to participants’ sexual orientation as well as increased reward-seeking behaviors in response to its associated cue compared to the less relevant sexual outcome and its associated cue, respectively, thereby reflecting that inter-individual differences in sexual concerns modulated these effects. These findings suggest that motivational influence on reward-related learning and behaviors involving sexual stimuli relies on inter-individual differences in concerns and contribute to fostering further insight into the mechanisms underlying human reward-seeking behaviors.
From Freud to Android: Constructing a Scale of Uncanny Feelings

Abstract The uncanny valley is a topic for engineers, animators, and psychologists, yet uncanny emotions are without a clear definition. Across three studies, we developed an 8-item measure of unnerved feelings, finding that it was discriminable from other affective experiences. In Study 1, we conducted an exploratory factor analysis that yielded two factors; an unnerved factor, which connects to emotional reactions to the uncanny, and a disoriented factor, which connects to mental state changes more distally following uncanny experiences. Focusing on the unnerved measure, Study 2 tests the scale’s convergent and discriminant validity, concluding that participants who watched an uncanny video were more unnerved than those who watched a disgusting, fearful, or a neutral video. In Study 3, we determined that our scale detects unnerved feelings created during early 2020 by the coronavirus pandemic; a distinct source of uncanniness. These studies contribute to the psychological and interdisciplinary understanding of this strange, eerie phenomenon of being confronted with what looms just beyond our understanding.
Under-nutrition and associated factors among human immunodeficiency virus-infected children in sub-Saharan Africa: A systematic review and meta-analysis.

Background: In developing world including sub-Saharan Africa, HIV/AIDS has worsened the impact of under-nutrition in children. HIV infected children are highly vulnerable to malnutrition. Even though under-nutrition screening and intervention are incorporated into the care plan of HIV infected children, it is continued as a major problem for HIV infected children in Africa. Hence, the main aim of this systematic review and meta-analysis was to estimate the pooled prevalence of under-nutrition and associated factors among children infected with HIV.Methods: Primary studies were retrieved from PubMed/ MEDLINE online, Science direct, and Hinari databases. We found a total of 1847 records from these databases. After removing papers my using different exclusion criteria, 26 studies that report the prevalence of under-nutrition were included. We used a standardized data extraction format prepared in Microsoft Excel. STATA- version 14 statistical software was used for analysis. Heterogeneity was evaluated through I2 test. A random-effects meta-analysis model was used to estimate the pooled prevalence of under-nutrition and its associated factors. The summary estimates were also presented using Forest plots and tables.Results: The pooled prevalence of stunting, underweight, and wasting in HIV infected children were 51.4% (95% CI: 46.3, 56.4), 39.0% (95% CI: 33.7, 44.3), and 24.5% (95% CI: 19.2, 29.8) respectively. Household insecurity was associated with stunting [OR= 5.50 (95% CI 3.36, 8.98]. Low family economic status [OR= 5.25 (95% CI: 2.52, 10.92)])], feeding frequency [OR= 0.32 (95% CI 0.172, 0.605)] and caretakers attending dietary counseling [OR= 0.367 (95% CI: 0.182, 0.739)] were significantly associated with under-weight among HIV infected children. Conclusions: The pooled prevalence of under-nutrition among HIV infected children was high. Routine nutritional assessment and nutritional support shall be strengthened, monitored, and evaluated in HIV infected children. Implementation of policies and strategy sated by a national and international stakeholder in ART care centers should get maximum emphasis to reduce undernutrition in HIV infected children.
Stigma towards Wuhan people during the COVID-19 epidemic: An exploratory study based on social media

Background: Stigma associated with infectious diseases is common and causes various negative effects on stigmatized people. With Wuhan as the center of the COVID-19 outbreak in China, its people have become an object of stigmatization. To provide necessary information for stigma mitigation, this study aims to identify the stigmatizing attitudes towards Wuhan people and trace their changes as the COVID-19 progressed in China by analyzing related posts on social media.Methods: We collected a total of 19,780 Weibo posts containing the keyword ‘Wuhan people’ and performed a content analysis to identify stigmatizing attitudes in the posts. Then we divided our observation time into three periods and performed Repeated Measures ANOVA to compare the differences in attitudes in three periods. Results: Results show that stigma was mild with 2.46% of related posts being stigmatizing. The percentages of stigmatizing posts differed significantly in 3 periods (F (2,66) = 5.60, p <. 01, η2= 0.15). The percentages of ‘Infectious’ posts (F (2,66) = 3.69, p <. 05, η2 = 0.10) and ‘Stupid’ posts (F (2,66) = 3.65, p <. 05, η2 = 0.10) are significantly different in 3 periods. The percentages of ‘Irresponsible’ posts is not significant different in 3 periods (F (2,66) = 0.63, p =. 53, η2 = 0.02). After government interventions, stigma didn’t reduce significantly, and stigma with ‘Infectious’ attitude even increased. It was until the government interventions took effect that stigma significantly reduced. Conclusions: This study found that stigma towards Wuhan people included diverse attitudes and changed at different periods. After government interventions but before they took effect, stigma with ‘Infectious’ attitude increased. After government interventions took effect, general stigma, and stigma with ‘Infectious’ and ‘Stupid’ attitudes decreased. This study constitutes an important endeavor to understand the stigma towards Wuhan people in China during the COVID-19 epidemic. Implications for stigma reduction and improvement of the public’s perception in different periods of epidemic control are discussed.
Professional judges’ disbelief in free will and punishment

There is a debate in psychology and philosophy on the societal consequences of casting doubts about individuals’ belief in free will. Research suggests that experimentally reducing free will beliefs might affect how individuals evaluate others’ behavior. Past research has demonstrated that reduced free will beliefs decrease laypersons’ tendency towards retributive punishment. This finding has been used as an argument for the idea that promoting anti-free will viewpoints in the public media might have severe consequences for the legal system, because it may move judges towards softer retributive punishments. However, actual implications for the legal system can only be drawn by investigating professional judges. In the present research, we investigated whether judges (N = 87) are affected by reading anti-free will messages. The results demonstrate that although reading anti-free will texts reduces judges’ belief in free will, their recommended sentences are not influenced by their (manipulated) belief in free will.
Recreational opium use as a risk factor for coronary artery disease: results from the premature coronary artery disease Milano-Iran (MIran) study

The spreading of recreational opium use pose new health related concerns. In some areas of Asia its use is believed to protect from cardiovascular disorders, such as coronary artery disease (CAD). However, whether opium use has an association with CAD is unclear. We aimed to investigate the association between opium use and CAD. We set up a case-control analysis, i.e., the premature CAD Milano-Iran (MIran) study by enrolling consecutive young patients who underwent a coronary angiography at the Tehran Heart Center, between 2009 and 2012. Incident cases with CAD were contrasted with controls for recreational opium use. Relative risks were calculated in terms of odds ratios (ORs) by logistic regression models adjusted for age, sex, cigarette smoking, body mass index, hypertension, hyperlipidaemia, and diabetes. Interaction analyses were performed between opium and major cardiovascular risk factors. 1011 patients with CAD (mean age 43.6 years) and 2002 controls (mean age 54.3 years) were included in the study. Habitual opium users had a 3.8-fold increased risk of CAD (95%CI 2.4–6.2) compared with non-users. The association was strongest for men, with a fully adjusted OR of 5.5 (95%CI 3.0-9.9). No interaction was observed for the combination of opium addiction and hypertension, or diabetes, but an excess in risk was found in opium users with hyperlipidaemia (OR 16.8, 95%CI 8.9–31.7, expected OR 12.2), suggesting supra-additive interaction. In conclusion, despite common beliefs, we showed that recreational opium use is associated with an increased risk of CAD, even when other cardiovascular risk factors are taken into account.
Validation to Spanish version of the COVID-19 Stress Scale

There is a global consensus about the potential of the COVID-19 pandemic to affect people's mental health. In this context, and prior to the formulation of mitigation strategies, tools are required that allow an objective and effective assessment of mental health risk. The purpose of this study was to evaluate the psychometric characteristics of COVID-19 Stress Scale, formulated by Taylor et al. (2020), based on the concept of COVID-19 Stress Syndrome. A national sample of 1214 participating adults was taken in Colombia, who answered a translated version of the scale. Evidence of a hexa-dimensional structure was obtained whose goodness of fit indicators were Chi2 = 1215,759, Sig. =. 000, CMIN / DF = 2.202, RMSEA = . 044, NFI = . 943, TLI = . 964, CFI =. 968 and FMIN = 1,967. Regarding reliability, an α = . 924 and Spearman-Brown = . 824 were obtained for the entire scale; the reliability indicators of the 6 subscales were also high. The similarities and differences in the findings with respect to the original psychometric study of the scale are discussed, as well as the utility and importance of the instrument as a tool in future efforts to mitigate the psychosocial effects of the pandemic