Miracle-dz/UniFAR-FTUs huggingface dataset:
Effects of intramedullary nailing and internal fixation plates on postoperative wound infection and pain in patients with distal tibia fractures: A meta‐analysis

Abstract A meta‐analysis was performed to assess the effects of intramedullary nailing (IMN) and internal fixation plates (IFP) on postoperative wound infection and pain in patients with distal tibia fractures, to provide evidence for the selection of surgical options for this group of patients. Computerised searches were performed on PubMed, Cochrane Library, EMBASE, MEDLINE, CNKI and Wanfang databases from the inception of each library to August 2023. All published randomised controlled trials (RCTs) comparing IMN with IFP for the treatment of patients with distal tibial fractures were selected. Literature screening, data extraction and literature evaluation were independently completed by two researchers. Data analysis was performed using the Review Manager 5.4 software. Overall, 25 RCTs with a total of 2011 patients were finally included, comprised by 1009 patients in the IMN group and 1002 patients in the IFP group. The rate of wound infection was significantly lower in the IMN group than that in the IFP group (5.05% vs. 9.58%, odds ratio [OR]: 0.52, 95% confidence intervals [CIs]: 0.37–0.73, p < 0.001). Meanwhile, the IMN group had a significantly higher rate of joint pain than that of the IFP group (14.57% vs. 2.90%, OR: 4.93, 95% CIs: 3.02–8.03, p < 0.00001), whereas the difference between the two surgical procedures in terms of operative time was not statistically significant (standardised mean differences: 0.08 95% CIs: −0.58–0.74, p = 0.82). Current clinical evidence suggests that both IMN and IFP are excellent treatments for distal tibial fractures. Although IMN is better in reducing postoperative wound infection, the risk of postoperative pain is higher. Thus, an appropriate surgical procedure should be selected in clinical practice in accordance with the actual situation of the patient, and IFP is used to reduce the incidence of postoperative joint pain when the anterior tibial soft tissue of the distal tibial fracture is in good condition, and vice versa. IMN is used to reduce the risk of infection.
Rapid Dot-Blot Immunoassay for Detecting Multiple Salmonella enterica Serotypes

Salmonella, a major contributor to foodborne infections, typically causes self-limiting gastroenteritis. However, it is frequently invasive and disseminates across the intestinal epithelium, leading to deadly bacteremia. Although the genus is subdivided into >2,600 serotypes based on their antigenic determinants, only few serotypes are responsible for most human infections. In this study, a rapid dot-blot immunoassay was developed to diagnose multiple Salmonella enterica serotypes with high incidence rates in humans. The feasibility of 10 commercial antibodies (four polyclonal and six monoclonal antibodies) was tested using the 18 serotypes associated with 67.5% Salmonella infection cases in the United States of America (U.S.A) in 2016. Ab 3 (polyclonal; eight of 18 serotypes), Ab 8 (monoclonal; 13 of 18 serotypes), and Ab 9 (monoclonal; 10 of 18 serotypes) antibodies exhibited high detection rates in western blotting and combinations of two antibodies (Ab 3+8, Ab 3+9, and Ab 8+9) were applied to dot-blot assays. The combination of Ab 3+8 identified 15 of the tested 18 serotypes in 3 h, i.e., S. Enteritidis, S. Typhimurium, S. Javiana, S. I 4,[5],12:i:-, S. Infantis, S. Montevideo, S. Braenderup, S. Thompson, S. Saintpaul, S. Heidelberg, S. Oranienburg, S. Bareilly, S. Berta, S. Agona, and S. Anatum, which were responsible for 53.7% Salmonella infections in the U.S. in 2016. This cost-effective and rapid method can be utilized as an on-site colorimetric method for Salmonella detection.
Representing Twentieth-Century Space–Time Climate Variability. Part I: Development of a 1961–90 Mean Monthly Terrestrial Climatology

Abstract The construction of a 0.5° lat × 0.5° long surface climatology of global land areas, excluding Antarctica, is described. The climatology represents the period 1961–90 and comprises a suite of nine variables: precipitation, wet-day frequency, mean temperature, diurnal temperature range, vapor pressure, sunshine, cloud cover, ground frost frequency, and wind speed. The climate surfaces have been constructed from a new dataset of station 1961–90 climatological normals, numbering between 19 800 (precipitation) and 3615 (wind speed). The station data were interpolated as a function of latitude, longitude, and elevation using thin-plate splines. The accuracy of the interpolations are assessed using cross validation and by comparison with other climatologies. This new climatology represents an advance over earlier published global terrestrial climatologies in that it is strictly constrained to the period 1961–90, describes an extended suite of surface climate variables, explicitly incorporates elevation.
Mesozoic tectonic and topographic evolution of Central Asia and Tibet: a preliminary synthesis

Abstract During the Late Palaeozoic–Mesozoic, Central Asia and Tibet were affected by several geodynamic episodes that induced either large-scale compression or widespread extension. The Late Palaeozoic final amalgamation of the Central Asian Orogenic Belt, the accretion of the Cimmerian blocks, the closure of the Mongol–Okhotsk Ocean and the accretion of the Neocimmerian blocks set the structural pattern of the continent. This Mesozoic tectonic heritage plays a first-order role in the localization and evolution of the Tertiary deformation of the continent. Similarly, large-scale Mesozoic topographic features are still preserved in Central Asia, where they form a non-negligible part of the present-day topography. This work aims at providing an overview of the major tectonic events that affected Central Asia and Tibet during the Late Palaeozoic and Mesozoic periods. The general topographic evolution of the continent is also described together with the accompanying climatic changes through time.
Modern Services Export Performances among Emerging and Developed Asian Economies

Advancements in information and communications technologies (ICTs) have expanded the possibilities for trade in modern services and many Asian emerging and developed economies are increasingly participating in these new trade activities. This study examines the export performances of emerging and developed Asian economies in selected modern services—computer and information, business and professional, and telecommunications—using a stochastic frontier gravity model. Estimation results show that the performances of emerging economies in South Asia and the Association of Southeast Asian Nations (ASEAN), in terms of realization of export potential, are considerably weaker than those of developed economies in North America and Europe. The results also show that the number of graduates and the quality of ICT infrastructure in emerging countries are among the key factors in realizing services export potential. These findings suggest that emerging economies need to remove "behind-the-border" constraints and adopt advanced technologies in order to catch up with high-performing developed countries.
The shared and unique neural correlates of personal semantic, general semantic, and episodic memory

One of the most common distinctions in long-term memory is that between semantic (i.e., general world knowledge) and episodic (i.e., recollection of contextually specific events from one’s past). However, emerging cognitive neuroscience data suggest a surprisingly large overlap between the neural correlates of semantic and episodic memory. Moreover, personal semantic memories (i.e., knowledge about the self and one’s life) have been studied little and do not easily fit into the standard semantic-episodic dichotomy. Here, we used fMRI to record brain activity while 48 participants verified statements concerning general facts, autobiographical facts, repeated events, and unique events. In multivariate analysis, all four types of memory involved activity within a common network bilaterally (e.g., frontal pole, paracingulate gyrus, medial frontal cortex, middle/superior temporal gyrus, precuneus, posterior cingulate, angular gyrus) and some areas of the medial temporal lobe. Yet the four memory types differentially engaged this network, increasing in activity from general to autobiographical facts, from autobiographical facts to repeated events, and from repeated to unique events. Our data are compatible with a component process model, in which declarative memory types rely on different weightings of the same elementary processes, such as perceptual imagery, spatial features, and self-reflection.
Mayaro virus pathogenesis and immunity in rhesus macaques

Mayaro virus (MAYV) is a mosquito-transmitted alphavirus that causes debilitating and persistent arthritogenic disease. While MAYV was previously reported to infect non-human primates (NHP), characterization of MAYV pathogenesis is currently lacking. Therefore, in this study we characterized MAYV infection and immunity in rhesus macaques. To inform the selection of a viral strain for NHP experiments, we evaluated five MAYV strains in C57BL/6 mice and showed that MAYV strain BeAr505411 induced robust tissue dissemination and disease. Three male rhesus macaques were subcutaneously challenged with 105 plaque-forming units of this strain into the arms. Peak plasma viremia occurred at 2 days post-infection (dpi). NHPs were taken to necropsy at 10 dpi to assess viral dissemination, which included the muscles and joints, lymphoid tissues, major organs, male reproductive tissues, as well as peripheral and central nervous system tissues. Histological examination demonstrated that MAYV infection was associated with appendicular joint and muscle inflammation as well as presence of perivascular inflammation in a wide variety of tissues. One animal developed a maculopapular rash and two NHP had viral RNA detected in upper torso skin samples, which was associated with the presence of perivascular and perifollicular lymphocytic aggregation. Analysis of longitudinal peripheral blood samples indicated a robust innate and adaptive immune activation, including the presence of anti-MAYV neutralizing antibodies with activity against related Una virus and chikungunya virus. Inflammatory cytokines and monocyte activation also peaked coincident with viremia, which was well supported by our transcriptomic analysis highlighting enrichment of interferon signaling and other antiviral processes at 2 days post MAYV infection. The rhesus macaque model of MAYV infection recapitulates many of the aspects of human infection and is poised to facilitate the evaluation of novel therapies and vaccines targeting this re-emerging virus.
An Ice Ridge in the Barents Sea, Part I: Morphology and Physical Parameters In-Situ

A first-year ice ridge was examined in the Barents Sea, west of Hopen, in May 2002. The morphology, geometry, physical and mechanical properties of this ridge are reported and discussed in relation to the literature. The keel depth was 15 m, the sail height 4.7 m, the average thickness of the consolidated layer was 1.9 m. The overall porosity was measured to be 24 %, and the porosity of the sail and the keel were respectively 15 % and 30 %. The thickness of the ice blocks varied from 0.1 to2 m. However, 40 % were between 0.30 and 0.35 m thick, 24 % were 0.5-0.7 m, and 21 % from 0.8 to 1.0 m thick. This indicates that initial rafting had occurred, and layers could also be seen in the blocks. The average length/width/thickness ratio of the blocks in the sail was 4.4:2.1:1. The salinity ranged from 0.2 (in the sail) up to 5.5 ppt, the density ranged from 0.78 to 0.99 kg/l, with Ρsail< Ρcons. layer< Ρrubble. Hardness tests were conducted, where a steel ball was dropped on the ice and the size of the penetration was measured. The hardness, the salinity and the density had a wavelike dependency on the depth; this wave pattern seems to correspond with the observed rafted layers.
Effect of INM on nutrient uptake, yield and quality of okra [Abelmoschus esculents (L.) Moench].

Effect of applying organic manures (vermicompost and neem cake) and inorganic fertilizers on nutrient uptake, yield and quality of okra was studied under field conditions at the Research Farm, Department of Horticulture, Dr. Panjabrao Deshmukh Krishi Vidyapeeth, Akola during summer 2012-13. Highest nutrient uptake by okra, yield of okra (no. of fruits plant, weigh fruit, fruit yield plant, fruit yield ha) and quality attributing character i.e. high protein content and low crude fibre content of okra fruits was recorded in treatment receiving 100 per cent RDF over other treatments which was statistically at par with treatment 75 per cent RDF + 12.5 per cent RDN through vermicompost + 12.5 per cent RDN through neem cake followed by treatment 75 per cent RDF + 25 per cent RDN through vermicompost and 75 per cent RDF + 25 per cent RDN through neem cake.
Integrative multi‐omics analysis reveals the critical role of the PBXIP1 gene in Alzheimer's disease

Abstract Alzheimer's disease (AD) is a neurodegenerative disorder, and its strongest risk factor is aging. A few studies have explored the relationship between aging and AD, while the underlying mechanism remains unclear. We assembled data across multi‐omics (i.e., epigenetics, transcriptomics, and proteomics, based on frozen tissues from the dorsolateral prefrontal cortex) and neuropathological and clinical traits from the Religious Orders Study and Rush Memory and Aging Project (ROSMAP). Aging was assessed using six DNA methylation clocks (including the Horvath clock, Hannum clock, Levine clock, HorvathSkin clock, Lin clock, and Cortical clock) that capture mortality risk in literature. After accounting for age, we first identified a gene module (including 263 genes) that was related to the integrated aging measure of six clocks, as well as three neuropathological traits of AD (i.e., β‐amyloid, Tau tangles, and tangle density). Interestingly, among 20 key genes with top intramodular connectivity of the module, PBXIP1 was the only one that was significantly associated with all three neuropathological traits of AD at the protein level after Bonferroni correction. Furthermore, PBXIP1 was associated with the clinical diagnosis of AD in both ROSMAP and three independent datasets. Moreover, PBXIP1 may be related to AD through its role in astrocytes and hippocampal neurons, and the mTOR pathway. The results suggest the critical role of PBXIP1 in AD and support the potential and feasibility of using multi‐omics data to investigate mechanisms of complex diseases. However, more validations in different populations and experiments in vitro and in vivo are required in the future.
Geographic tongue: What is this disease?

Geographic tongue or benign migratory glossitis, is a unique and peculiar tongue condition, producing a map‐like appearance with filiform papillae atrophy, on different parts of the tongue. The lesions change in shape with time. The exact etiology remains unknown, although it has been suggested relating the lingual microbiota of a patient. The association between geographic tongue and psoriasis has long been pointed out, and histological similarities existed between both as well. Increasingly, recent findings suggest the involvement of certain oral bacteria. Here, we discuss these findings with an overview of the recent literature.
Experiences of Ambulatory Patients With Huntington's Disease With Case Management

Purpose/Objectives: Huntington's disease (HD) requires high-quality care to reduce disruption of the patient system, prevent crisis situations, and prevent early admission in a nursing home. In the Netherlands, case management has been available for the last to 9 years for people with HD. However, there is a notable gap in understanding experiences and beliefs of HD patients regarding case managers' care, guidance, and support for quality of life. To improve the international quality of care for people with HD, insight in experiences of ambulatory HD patients with the care, guidance, and support received from a case manager HD (CMHD) is crucial. Primary Practice Setting: Ambulatory care. Findings/Conclusions: Ambulatory patients with HD highly appreciate and value the role and support of the CMHD. This was reflected in four themes: (1) the CMHD as a person, with commitment, sympathy, and reliability as central concepts; (2) the CMHD as a professional, with the key roles of coordinator, point of contact, expert, and supporter; (3) impact of the CMHD on quality of life, with support of coping with decline and monitoring the home situation as important subthemes; and (4) support of the CMHD for family members, with providing help and giving attention as subthemes. This insight into patients' experiences of the CMHD's role adds value to the improvement of the international quality of care for people with HD. Implications for Case Management Practice: Commitment, expertise, support for both family members and patients, and bond of trust from the CMHD are experienced as very valuable. These qualitative findings from a patient's perspective add significantly to the body of knowledge on CMHD's role and practices as “spider at the center of the web. ”
Against cortical reorganisation

Neurological insults, such as congenital blindness, deafness, amputation, and stroke, often result in surprising and impressive behavioural changes. Cortical reorganisation, which refers to preserved brain tissue taking on a new functional role, is often invoked to account for these behavioural changes. Here, we revisit many of the classical animal and patient cortical remapping studies that spawned this notion of reorganisation. We highlight empirical, methodological, and conceptual problems that call this notion into doubt. We argue that appeal to the idea of reorganisation is attributable in part to the way that cortical maps are empirically derived. Specifically, cortical maps are often defined based on oversimplified assumptions of ‘winner-takes-all’, which in turn leads to an erroneous interpretation of what it means when these maps appear to change. Conceptually, remapping is interpreted as a circuit receiving novel input and processing it in a way unrelated to its original function. This implies that neurons are either pluripotent enough to change what they are tuned to or that a circuit can change what it computes. Instead of reorganisation, we argue that remapping is more likely to occur due to potentiation of pre-existing architecture that already has the requisite representational and computational capacity pre-injury. This architecture can be facilitated via Hebbian and homeostatic plasticity mechanisms. Crucially, our revised framework proposes that opportunities for functional change are constrained throughout the lifespan by the underlying structural ‘blueprint’. At no period, including early in development, does the cortex offer structural opportunities for functional pluripotency. We conclude that reorganisation as a distinct form of cortical plasticity, ubiquitously evoked with words such as ‘take-over’’ and ‘rewiring’, does not exist.
Roux‐en‐Y versus one‐anastomosis gastric bypass (RYSA study): weight loss, metabolic improvements, and nutrition at 1 year after surgery, a multicenter randomized controlled trial

Although it has been suggested that one‐anastomosis gastric bypass (OAGB) is metabolically superior to the “gold standard,” i.e., Roux‐en‐Y gastric bypass (RYGB), there is little robust evidence to prove it. Because this result may arise from the typically longer length of bypassed intestine in OAGB, here, the authors standardized the bypass length in RYGB and OAGB and compared weight loss and metabolic outcomes in a randomized controlled trial.
Late Pleistocene slip rate of the Höh Serh–Tsagaan Salaa fault system, Mongolian Altai and intracontinental deformation in central Asia

SUMMARY The Mongolian Altai is an intracontinental oblique contractional orogen related to the far-field effects of the Indo-Asian collision. Global Positioning System (GPS) data suggest that ∼10–15 per cent of total Indo-Asia convergence is accommodated across this orogen. The Hoh Serh–Tsagaan Salaa fault system is one of several NNW–SSE-trending oblique contractional faults acting to partition strain and accommodate shortening and dextral shear in the Mongolian Altai. This fault zone displaces late Pleistocene alluvium along the southwest piedmont of the Hoh Serh range in western Mongolia. Along the central third of the fault zone, strain is partitioned onto two separate strands, one that accommodates nearly pure dextral shear and one that accommodates thrust motion. We determined late Pleistocene rates of deformation along each of the Hoh Serh–Tsagaan Salaa fault strands based on differential GPS surveys and cosmogenic nuclide 10Be geochronology. Combining the measured offsets and 10Be dates yields a minimum right-lateral slip rate of 0.9 +0.2/−0.1 mm a−1; the minimum shortening rate is 0.3 ± 0.1 mm a−1, with uplift of at least 0.1 ± 0.1 mm a−1. Resolving the shortening and dextral components of deformation yields a slip vector of 0.8 +0.2/−0.1 mm a−1 toward 336°. This long-term deformation vector is consistent with the short-term strain field determined by GPS in the region and indicates that ∼20 per cent of Indo-Asian deformation in the Mongolian Altai (∼2 per cent of the total Indo-Asia strain accumulation) occurs along the Hoh Serh–Tsagaan Salaa fault zone. Although rate data for other active faults in the Mongolian Altai are sparse, our results suggest that strain may be accommodated almost exclusively on discrete structures in this intraplate tectonic setting.
Is the Amik Basin (SE Turkey) a triple-junction area? Analyses of SPOT XS imagery and seismicity

In the eastern Mediterranean, plate motions occur between the Arabia/Anatolia, Africa/Arabia and Anatolia/Africa boundaries along the Amanos Fault, the Dead Sea Fault and the Cyprus Arc, and the extension of the latter on land. Detailed enhancement and classification procedures applied to SPOT XS imagery of the Hatay region, and centred on the Quaternary Amik Basin, have revealed a prominent NE–SW-trending tectonic lineament. Recent seismicity suggests that this NE–SW-trending lineament dies out in the Quaternary Amik Basin in the east and continues to the Cyprus Arc to the south-west. Structural lineament extensions derived from SPOT XS imagery using linear edge enhancement and unsupervised classification methods and the distribution of seismicity in the Hatay region show that this region has been affected by the East Anatolian Fault Zone, the Dead Sea Fault Zone and the Cyprus–Antakya Transform fault. These fault associations accommodate northerly movement of the African and Arabian plates toward the Eurasian plate. The Amik Basin appears to have been formed by interaction among the Amanos Fault interpreted here as a continuation of the East Anatolian Fault the left-lateral Dead Sea Fault, and the left-lateral Cyprus–Antakya transform fault. Active faults belonging to the aforementioned structural zones meet one another to form a triple junction at the Amik Basin near Antakya.