Miracle-dz/UniFAR-FTUs huggingface dataset:
Gas Microflows in the Slip Flow Regime: A Critical Review on Convective Heat Transfer

Accurate modeling of gas microvection is crucial for a lot of MEMS applications (microheat exchangers, pressure gauges, fluidic microactuators for active control of aerodynamic flows, mass flow and temperature microsensors, micropumps, and microsystems for mixing or separation for local gas analysis, mass spectrometers, vacuum, and dosing valves…). Gas flows in microsystems are often in the slip flow regime, characterized by a moderate rarefaction with a Knudsen number of the order of 10 � 2 ‐10 � 1 . In this regime, velocity slip and temperature jump at the walls play a major role in heat transfer. This paper presents a state of the art review on convective heat transfer in microchannels, focusing on rarefaction effects in the slip flow regime. Analytical and numerical models are compared for various microchannel geometries and heat transfer conditions (constant heat flux or constant wall temperature). The validity of simplifying assumptions is detailed and the role played by the kind of velocity slip and temperature jump boundary conditions is shown. The influence of specific effects, such as viscous dissipation, axial conduction and variable fluid properties is also discussed. [DOI: 10.1115/1.4005063]
FLUID MECHANICS AND RHEOLOGY OF DENSE SUSPENSIONS

▪ Abstract We review the fluid mechanics and rheology of dense suspensions, emphasizing investigations of microstructure and total stress. “Dense” or “highly concentrated” suspensions are those in which the average particle separation distance is less than the particle radius. For these suspensions, multiple-body interactions as well as two-body lubrication play a significant role and the rheology is non-Newtonian. We include investigations of multimodal suspensions, but not those of suspensions with dominant nonhydrodynamic interactions. We consider results from both physical experiments and computer simulations and explore scaling theories and the development of constitutive equations.
Neutron production in terrestrial gamma ray flashes

[1] Terrestrial gamma ray flashes (TGFs) are brief bursts of photons with energies up to 20 MeV typically observed in association with lightning. Such energetic photons may undergo photonuclear reactions with nontrivial cross section in the vicinity of the giant dipole resonance. Pulses of neutrons have been observed experimentally in coincidence with lightning, suggesting such reactions are observable. We present simulations of expected photoneutron production based on initial conditions inferred from observations ofTGFs. We predict an average of ~10 12 neutrons produced per TGF and give energy, time, and space distributions of neutrons produced and neutrons reaching ground and satellite altitude. The simulation results are consistent with some observations and suggest further experiments may be profitable.
The Seoul Neuropsychological Screening Battery (SNSB) for Comprehensive Neuropsychological Assessment

The Seoul Neuropsychological Screening Battery (SNSB) is known as a representative comprehensive neuropsychological evaluation tool in Korea since its first standardization in 2003. It was the main neuropsychological evaluation tool in the Clinical Research Center for Dementia of South Korea, a large-scale multi-center cohort study in Korea that was started in 2005. Since then, it has been widely used by dementia clinicians, and further solidified its status as a representative dementia evaluation tool in Korea. Many research results related to the SNSB have been used as a basis for the diagnosis and evaluation of patients in various clinical settings, especially, in many areas of cognitive assessment, including dementia evaluation. The SNSB version that was updated in 2012 provides psychometrically improved norms and indicators through a model-based standardization procedure based on a theoretical probability distribution in the norm’s development. By providing a score for each cognitive domain, it is easier to compare cognitive abilities between domains and to identify changes in cognitive domain functions over time. Through the development of the SNSB-Core, a short form composed of core tests, which also give a composite score was provided. The SNSB is a useful test battery that provides key information on the evaluation of early cognitive decline, analysis of cognitive decline patterns, judging the severity of dementia, and differential diagnosis of dementia. This review will provide a broad understanding of the SNSB by describing the test composition, contents of individual subtests, characteristics of standardization, analysis of the changed standard score, and related studies.
The Impact of Living Arrangements on the Prevalence of Falls after Total Joint Arthroplasty: A Comparison between Institutionalized and General Geriatric Population

Due to population aging, there is an increasing need for orthopedic surgery, especially total knee arthroplasty (TKA) and total hip arthroplasty (THA). In geriatric patients, postoperative falls are common events which can compromise the success of these expensive procedures. The aim of our study was to assess the influence of living arrangements on the prevalence of postoperative falls following joint replacement. We included 441 patients after TKA or THA, living in nursing homes, alone or with family. The prevalence of falls in the first 2 years (15.2%) was significantly influenced by living arrangements: patients with TKA or THA living alone had three times higher odds of falling compared to those living with family, and institutionalized patients with THA had four times higher odds of falling compared to those living with family. Of 67 patients who fell, 6 (8.9%) needed reintervention. For TKA patients, the fall rates were not significantly different between institutions and family, indicating the interest of nursing homes in offering proper care. However, for the THA group, the results were poorer, emphasizing the need for improvement in postoperative rehabilitation. Further multi-centric studies are required for generalizing the impact of living arrangements on fall prevalence after joint replacement.
ESTIMATION OF THE CONCENTRATION OF YELLOW SUBSTANCE IN NATURAL WATERS BY BEAM ATTENUATION COEFFICIENT SPECTRA

Two ways for describing the influence ofthe yellow substance on the properties of the water environment were considered: (1) by using spectral attenuation coefficients of yellow substance measured from the samples offiltered water; and (2) by using effective concentrations of yellow substance in water estimated from optical measurements. Both ways have some positive features, but also certain shortcomings. The yellow substance concentration values determined using different numerical parameters (obtained by different investigations) in the yellow substance absorption coefficient formula are compared and analysed. The values of the slope parameter in this formula are calculated using our spectrophotometrical measurements in the Baltic Sea and in some Estonian lakes. The differences between the absorption coefficients of the yellow substance and the corresponding beam (and also diffuse) attenuation coefficients of the filtered water are discussed and estimated. In addition to the classical method, which uses for the determination of the yellow substance concentration the beam attenuation coefficient spectra of the filtered water, an alternative method based on the measurements of the beam attenuation coefficient spectra of unfiltered water is described. The reliability of the yellow substance concentration values (obtained by both methods) depends mainly on the reliability ofthe values of specific absorption coefficients of the yellow substance. For improving the accuracy of these results new, more authentic data on the optical properties of the yellow substance for different types of water bodies are highly necessary.
Effects of a Physical Exercise Programme through Service-Learning Methodology on Physical Activity, Physical Fitness and Perception of Physical Fitness and Health in University Students from Spain: A Preliminary Study

The practice of physical activity has been reported on countless occasions for the benefits it has on people’s holistic health. However, today’s society has high levels of inactivity and sedentary lifestyles, which highlights the importance of promoting active and healthy states in the population. As a mechanism to improve body composition, physical condition and perceived values of one’s own physical condition and health status, the implementation of a strength training programme in the university community was proposed using a methodology based on Service-Learning. The participants were 12 students as coaches and 57 students from different university degrees as coachees (17 boys and 40 girls); the ages of the participants ranged from 18 to 33 years (M = 22.00; SD = 2.96). The variables of body composition, physical fitness, physical activity level and perception of fitness and health were assessed. Differences between pre- and post-intervention results were analysed using the Student’s t-test and Wilcoxon test for ordinal self-perception variables. The results showed significant improvements in all the variables evaluated after the intervention. In conclusion, we would like to highlight the benefits of physical activity and the need to continue implementing action and intervention plans to encourage and promote its practice in all sectors of the population.
Left Ventricular Hypertrophy and Ventricular Tachyarrhythmia: The Role of Biomarkers

Left ventricular hypertrophy (LVH) refers to a complex rebuilding of the left ventricle that can gradually lead to serious complications—heart failure and life-threatening ventricular arrhythmias. LVH is defined as an increase in the size of the left ventricle (i.e., anatomically), therefore the basic diagnosis detecting the increase in the LV size is the domain of imaging methods such as echocardiography and cardiac magnetic resonance. However, to evaluate the functional status indicating the gradual deterioration of the left ventricular myocardium, additional methods are available approaching the complex process of hypertrophic remodeling. The novel molecular and genetic biomarkers provide insights on the underlying processes, representing a potential basis for targeted therapy. This review summarizes the spectrum of the main biomarkers employed in the LVH valuation.
The decay of turbulence in thermally stratified flow

The decay of grid-generated turbulence in the presence of strong thermal stratification is studied in a continuously stratified, open-loop wind tunnel at Brunt–Väisälä frequencies up to 2.5s−1. The data include one-point statistical measurements through moments of fourth order and associated power- and cross-spectra. Cross-channel phase measurements are used to analyse the scales of correlation of velocity and temperature. The present data are considerably more coherent than previous salt-stratified data, and the structural form of stratified turbulence is thus more clearly manifested. No internal wave effects are observed at any stage of the decay. Stratified turbulence is found to be a two-scale process dominated by buoyancy forces at large scales of motion and dissipative effects at small scales. The two-scale structure is used to develop universal buoyancy scalings for the decay of the vertical heat flux, the scalar variance, and the molecular dissipation rates, and, in particular, for the vertical velocity decay. Velocity and temperature spectra satisfy universal equilibrium scaling at high wavenumbers, but show buoyancy effects at small wavenumbers. The flow remains isotropic at high wavenumbers over the entire range of turbulent decay studied. Cospectral and phase data are used to validate the two-scale model of the turbulence. The flow may show large-scale restratification while active turbulence persists at smaller scales, so that the vanishing of the vertical transport does not represent extinction of turbulent motion. Additionally, an original universal equilibrium scaling is developed for the cross-spectrum. Lengthscale evolution is measured, and the overturning and buoyancy lengthscales (associated with potential and kinetic energy, respectively) are found to characterize flow development. The role of the Prandtl number is assessed by comparison to previous works, and the Prandtl number is found to have a significant influence upon stratified turbulence evolution.
Stigmatizing Monkeypox and COVID-19: A Comparative Framing Study of The Washington Post’s Online News

Background: Stigma relating to health can result in a broad range of vulnerabilities and risks for patients and healthcare providers. The media play a role in people’s understanding of health, and stigma is socially constructed through many communication channels, including media framing. Recent health issues affected by stigma include monkeypox and COVID-19. Objectives: This research aimed to examine how The Washington Post (WP) framed the stigma around monkeypox and COVID-19. Guided by framing theory and stigma theory, online news coverage of monkeypox and COVID-19 was analyzed to understand the construction of social stigma through media frames. Methods: This research used qualitative content analysis to compare news framings in The Washington Post’s online news coverage of monkeypox and COVID-19. Results: Using endemic, reassurance, and sexual-transmission frames, The Washington Post predominantly defined Africa as the source of monkeypox outbreaks, indirectly labeled gays as a specific group more likely to be infected with monkeypox, and emphasized that there was no need to worry about the spread of the monkeypox virus. In its COVID-19 coverage, The Washington Post adopted endemic and panic frames to describe China as the source of the coronavirus and to construct an image of panic regarding the spread of the virus. Conclusions: These stigma discourses are essentially manifestations of racism, xenophobia, and sexism in public health issues. This research confirms that the media reinforces the stigma phenomenon in relation to health through framing and provides suggestions for the media to mitigate this issue from a framing perspective.
Chlorambucil-Loaded Graphene-Oxide-Based Nano-Vesicles for Cancer Therapy

In this study, the authors have designed biocompatible nano-vesicles using graphene oxide (GO) for the release of chlorambucil (CHL) drugs targeting cancerous cells. The GO sheets were first sulfonated and conjugated with folic acid (FA) molecules for controlled release and high loading efficiency of CHL. The chlorambucil (CHL) drug loading onto the functionalized GO surface was performed through π-π stacking and hydrophobic interactions with the aromatic planes of GO. The drug loading and “in vitro” release from the nano-vesicles at different pH were studied. The average particle size, absorption, and loading efficiency (%) of FA-conjugated GO sheets (CHL-GO) were observed to be 300 nm, 58%, and 77%, respectively. The drug release study at different pH (i.e., 7.4 and 5.5) showed a slight deceleration at pH 7.4 over pH 5.5. The amount of drug released was very small at pH 7.4 in the first hour which progressively increased to 24% after 8 h. The rate of drug release was faster at pH 5.5; initially, 16% to 27% in the first 3 h, and finally it reached 73% after 9 h. These observations indicate that the drug is released more rapidly at acidic pH with a larger amount of drug-loading ability. The rate of drug release from the CHL-loaded GO was 25% and 75% after 24 h. The biotoxicity study in terms of % cell viability of CHL-free and CHL-loaded GO against human cervical adenocarcinoma cell line was found to have lower cytotoxicity of CHL-loaded nano-vesicles (IC50 = 18 μM) as compared to CHL-free (IC50 = 8 μM). It is concluded that a high drug-loading efficiency and controlled release with excellent biotoxicity of CHL-GO offers an excellent application in the biomedical field.
Burden and trend of cardiovascular diseases among people under 20 years in China, Western Pacific region, and the world: An analysis of the global burden of disease study in 2019

Objectives Cardiovascular disease (CVD) is a global public health concern, but its disease burden and trend have been poorly studied in people younger than 20 years. This study aimed to fill this gap by evaluating the CVD burden and trend in China, Western Pacific Region, and the world from 1990 to 2019. Methods We applied the 2019 Global Burden of Diseases (GBD) analytical tools to compare the incidence, mortality, and prevalence of CVD, years lived with disability (YLDs), years of life lost (YLLs), and disability-adjusted life years (DALYs) among people younger than 20 years from 1990 to 2019 in China, the Western Pacific Region, and the world. The trends of disease burden between 1990 and 2019 evaluated using the average annual percent change (AAPC) and the 95% uncertainty interval (UI) were reported. Results Globally, in 2019, there were 2.37 (95% UI: 1.82 to 3.05) million incidence of CVD, 16.85 (95% UI: 12.56 to 22.03) million prevalence of CVD, and 74386.73 (95% UI: 64543.82 to 86310.24) deaths due to CVD among people under 20 years of age. The trends for DALYs decreased among children and adolescents in China, Western Pacific Region, and the world (AAPC = −4.29, 95% CI: −4.38% to −4.20%; AAPC = −3.37, 95% CI: −3.48% to −3.26%; AAPC = −2.17, 95% CI: −2.24% to −2.09%; p < 0.001, respectively) between 1990 and 2019. With the increase in age, the AAPC values of mortality, YLLs, and DALYs showed a notable downward trend. The AAPC values of mortality, YLLs, and DALYs in female patients were significantly greater than those in male patients. For all subtypes of CVD, the AAPC values showed a downward trend, with the largest reduction observed for stroke. From 1990 to 2019, a decline in the DALY rate for all CVD risk factors was observed, with a significant decrease in environmental/occupational risk factors. Conclusion Our study shows a decline in the burden and trend of CVD among people younger than 20 years, which reflects the success in reducing disability, premature death, and the early incidence of CVD. More effective and targeted preventive policies and interventions aimed at mitigating preventable CVD burden and addressing risk factors from childhood are urgently needed.
Plasma, urine, and stool metabolites in response to dietary rice bran and navy bean supplementation in adults at high-risk for colorectal cancer

Introduction Dietary intake of whole grains and legumes and adequate physical activity (PA) have been associated with reduced colorectal cancer (CRC) risk. A single-blinded, two-arm, randomized, placebo-controlled pilot trial was implemented to evaluate the impact of a 12-week dietary intervention of rice bran + navy bean supplementation and PA education on metabolite profiles and the gut microbiome among individuals at high risk of CRC. Methods Adults (n=20) were randomized 1:1 to dietary intervention or control. All participants received PA education at baseline. Sixteen study foods were prepared with either heat-stabilized rice bran + navy bean powder or Fibersol®-2 as a placebo. Intervention participants consumed 30 g rice bran + 30 g navy bean powder daily; those in the control group consumed 10 g placebo daily. Non-targeted metabolite profiling was performed by UPLC-MS/MS to evaluate plasma, urine, and stool at 0, 6, and 12 weeks. Stool was also analyzed for primary and secondary bile acids (BAs) and short chain fatty acids (SCFAs) by UPLC-MS/MS and microbial community structure via 16S amplicon sequencing. Two-way ANOVA was used to compare differences between groups for metabolites, and mixed models were used to compare differences between groups for BAs, SCFAs, and alpha and beta diversity measures of microbial community structure. Results Across biological matrices, the intervention resulted in changes to several amino acid and lipid metabolites, compared to control. There was a 2.33-fold difference in plasma (p<0.001) and a 3.33-fold difference in urine (p=0.008) for the amino acid S-methylcysteine at 12 weeks. Fold-differences to 4-methoxyphenol sulfate in plasma and urine after 6 and 12 weeks (p<0.001) was a novel result from this combined rice bran and navy bean intervention in people. A 2.98-fold difference in plasma (p=0.002) and a 17.74-fold difference in stool (p=0.026) was observed for the lipid octadecenedioylcarnitine at 12 weeks. For stool BAs, 3-oxocholic acid was increased at 12 weeks compared to control within a subset of individuals (mean difference 16.2 ug/uL, p=0.022). No significant differences were observed between groups for stool SCFAs or microbial community structure. Discussion Dietary intake of rice bran + navy beans demonstrates beneficial modulation of host and gut microbial metabolism and represents a practical and affordable means of increasing adherence to national guidelines for CRC control and prevention in a high-risk population.
Which site is better for prophylactic ileostomy after laparoscopic rectal cancer surgery? By the specimen extraction site or new site: A systematic review and meta-analysis

Background There is controversy about the outcomes of prophylactic ileostomy via the specimen extraction site (SES) after laparoscopic rectal cancer surgery (LRCS). We, therefore, performed a meta-analysis to determine the efficacy and safety of stoma through the SES versus new site (NS). Methods All relevant studies from 1997 to 2022 were searched in the PubMed, EMBASE, Cochrane Library, CNKI, VIP databases. This meta-analysis was performed using RevMan software 5.3 for statistical analysis. Results 7 studies with 1736 patients were included. The present meta-analysis noted that prophylactic ileostomy via SES was associated with a higher risk of overall stoma-related complications, especially parastomal hernia (OR, 2.39, 95% CI 1.43-4.00; p=0.0008). No statistical difference was found in terms of wound infection, ileus, stoma edema, stoma prolapse, stoma necrosis, stoma infection, stoma bleeding, stoma stenosis, skin inflammation around the stoma, stoma retraction and postoperative pain score on postoperative day 1 and 3 between SES group and NS group. However, prophylactic ileostomy via SES was associated with lesser blood loss (MD = -0.38, 95% CI: -0.62 - -0.13; p=0.003), shorter operation time(MD = -0.43, 95% CI: -0.54 - -0.32 min; p<0.00001), shorter post-operative hospital stay (MD = -0.26, 95% CI: -0.43 - -0.08; p=0.004), shorter time to first flatus(MD = -0.23, 95% CI: -0.39 - -0.08; p=0.003) and lower postoperative pain score on postoperative day 2. Conclusion Prophylactic ileostomy via SES after LRCS reduces new incision, decreases operative time, promotes postoperative recovery, and improves cosmetic outcomes, but may increase the incidence of parastomal hernias. The vast majority of parastomal hernias can be repaired by closing the ileostomy, therefore SES remain an option for temporary ileostomy after LRCS.