Miracle-dz/UniFAR-FTUs huggingface dataset:
Ripening Regulation of Banana Cv. Malbhog Using Different Ripening Inducers

This experiment was carried out under the study entitled “Ripening regulation of the banana Cv. Malbhog using different ripening inducers” for controlling the ripening of the banana, for improvement of quality attributes and post-harvest life of banana. The experiment was conducted at laboratory of horticulture, Agriculture and Forestry University, Rampur, Chitwan, Nepal from 14th March to 16th April 2019. These experiments were laid out in completely randomized design in which the first experiment comprised of seven treatments consisting of distilled water spray, ethephon @ 250 ppm, ethephon @ 500 ppm, ethephon @750 ppm, ethephon@1000 ppm, Dhurseli (Colebrookea oppositifolia) leaves and Ripe banana replicated thrice. Different post-harvest parameters were recorded at the interval of two days for the experiment till any one of the treatment attained score 6 in the color chart. In this experiment, the CI-6 stage was reached earlier on the 9th day with the use of ethephon @ 1000 ppm but ethephon @ 500 ppm was found more effective regarding quality parameters with TSS (21˚B), and TSS/TA (34.66). The maximum physiological loss in weight (12.927%) and pulp peel ratio (3.65) was observed with ethephon@1000ppm and the minimum was achieved in banana sprayed with distilled water. The shelf life of banana was seen minimum (13.33 days) in ethephon @ 1000 ppm and maximum (20.33 days) in banana sprayed with distilled water.
Wind Pressure and Air Flow in a Full-Scale Building Model under Cross Ventilation

Abstract The observation of wind pressure acting on the wall and floor of a full-scale building model under cross ventilation was carried out. The measurement of air flow was also undertaken, and the existing prediction theory of the air flow rate, namely the orifice flow equation, including the discharge coefficient, was evaluated for its accuracy. At the same time, a method of predicting the discharge coefficient has been proposed and tested. In conclusion, a tentative relationship between the discharge coefficient and the difference of wind pressure coefficient across the opening has been developed. In addition, the background concerning the difficulty of using the orifice flow equation has been described.
Plasma and ovarian metabolomic responses to chronic stress in female mice

Background Chronic stress may affect metabolism of amino acids, lipids, and other small molecule metabolites, but these alterations may differ depending on tissue evaluated. We examined metabolomic changes in plasma and ovarian tissue samples from female mice due to chronic stress exposure. Methods At 12 weeks old, healthy, female, C57 black mice were randomly assigned to three weeks of chronic stress using daily restraint (2 hours/day; n=9) or normal care (n=10). Metabolomic profiling was conducted on plasma and ovarian tissues. Using the Wilcoxon Rank Test, Metabolite Set Enrichment Analysis, and Differential Network Analysis we identified metabolomic alterations occurring in response to restraint stress. All p-values were corrected for multiple testing using the false discovery rate approach. Results In plasma, individual lysophosphatidylcholines (positively) and the metabolite classes carnitines (positively), diacylglycerols and triacylglycerols (inversely) were associated with restraint stress (adjusted-p’s<0.2). In contrast, diacylglycerols and triacylglycerols were increased while carnitines were decreased in ovarian tissue from stressed mice (adjusted-p’s<0.2). However, several metabolites (cholesteryl esters, phosphatidylcholines/ phosphatidylethanolamines plasmalogens and multiple amino acids) were consistently inversely associated with restraint stress in plasma and ovarian tissue (adjusted-p’s<0.2). Conclusion We identified differences in multiple lipid and amino acid metabolites in plasma and ovarian tissue of female mice after exposure to chronic stress. Some affected metabolites (primarily triacylglycerols and diacylglycerols) exhibited opposite associations with chronic stress in plasma (a marker of systemic influences) versus in ovarian tissue (representing local changes), suggesting research to understand the biological impact of chronic stress needs to consider both systemic and tissue-specific alterations.
Effect of Lipopolysaccharides on Liver Tumor Metastasis of twist1a/krasV12 Double Transgenic Zebrafish

The poor prognosis of patients diagnosed with hepatocellular carcinoma (HCC) is directly associated with the multi-step process of tumor metastasis. TWIST1, a basic helix-loop-helix (bHLH) transcription factor, is the most important epithelial-mesenchymal transition (EMT) gene involved in embryonic development, tumor progression, and metastasis. However, the role that TWIST1 gene plays in the process of liver tumor metastasis in vivo is still not well understood. Zebrafish can serve as a powerful model for cancer research. Thus, in this study, we crossed twist1a+ and kras+ transgenic zebrafish, which, respectively, express hepatocyte-specific mCherry and enhanced green fluorescent protein (EGFP); they also drive overexpression of their respective transcription factors. This was found to exacerbate the development of metastatic HCC. Fluorescence of mCherry and EGFP-labeled hepatocytes revealed that approximately 37.5% to 45.5% of the twist1a+/kras+ double transgenic zebrafish exhibited spontaneous tumor metastasis from the liver to the abdomen and tail areas, respectively. We also investigated the inflammatory effects of lipopolysaccharides (LPS) on the hepatocyte-specific co-expression of twist1a+ and kras+ in double transgenic zebrafish. Following LPS exposure, co-expression of twist1a+ and kras+ was found to increase tumor metastasis by 57.8%, likely due to crosstalk with the EMT pathway. Our results confirm that twist1a and kras are important mediators in the development of metastatic HCC. Taken together, our in-vivo model demonstrated that co-expression of twist1a+/kras+ in conjunction with exposure to LPS enhanced metastatic HCC offers a useful platform for the study of tumor initiation and metastasis in liver cancer.
Gradation processes and channel evolution in modified West Tennessee streams; process, response, and form

Channelization of alluvial channels in West Tennessee has increased energy conditions along main stems and tributaries and initiated systematic trends in channel adjustment. Gradation processes and adjustment trends are a function of the magnitude and extent of an imposed disturbance on a stream channel and the location of the adjusting reach in the fluvial network. Degradation at a site is described by power-decay equations. Exponents denoting the nonlinear rate of downcutting with time decrease with distance upstream from the area of maximum disturbance, and generally range from -0.002 to -0.04. Aggradation occurs in reaches immediately downstream from the area of maximum disturbance and in upstream reaches following overadjustment by degradation, and also can be described by power equations. Aggradation rates increase linearly with distance downstream and reach a maximum of 0.12 meters per year. Adjustment of channel width by mass-wasting processes follows degradation and continues through the aggradational phases. Bank instabilities are induced after downcutting creates bank heights and angles that exceed the critical conditions of the material. Piping in the loess-derived bank materials enhances bank-failure rates. Development of the bank profile is defined in terms of three dynamic and observable surfaces: vertical face (70° to 90°), upper bank (25° to 50°), and slough line (20° to 25°). Both the vertical face and upper bank sections represent major failure planes, and masses of failed bank material often come to rest on the upper bank. The slough line develops from additional flattening and downslope movement by low-angle slides and fluvial reworking, and is the initial site of reestablishing riparian vegetation and stable bank conditions. A six-stage, semiquantitative model of channel evolution in disturbed channels is developed by quantifying gradation trends, by interpreting process-response relations during stages of bank-slope development, and by interpreting changes over space as changes over time.
Corporate Social Responsibility and Leverage Level on High Profile Industries at Indonesian Stock Exchange of 2015-2019 Period

This study aims at analyzing the effect of corporate social responsibility (CSR) and the level of use of debt on financial performance. The variables used in this study included corporate social responsibility, debt, age, size and employees. This study uses a quantitative paradigm with the least square regression panel data processing method. The population in this study is all non-financial sector companies included in the high profile industry category at the Indonesia Stock Exchange (ISE) for the 2015-2019 period. The results prove that CSR has a significant positive effect on financial performance as proxied by Tobin's Q. When a company's CSR is high, it will have a positive impact on its financial performance. Then, leverage has a negative effect on the performance because the higher the debt, the lower the company's performance.
Lower-Limb Muscle Contractile Properties, Explosive Power and the Subjective Response of Elite Soccer Players to the COVID-19 Lockdown

The present study examined the effects of the lockdown period on basic anthropometric measures, countermovement jumping performance, skeletal muscle contractile properties derived from tensiomyography (TMG), injury incidence, and self-assessed general well-being in elite soccer players. A total of 266 players were assessed before (PRE) and 32 players were reassessed 11 days after (POST) the COVID-19 period. Significant changes in the TMG parameters were observed POST compared to PRE: contraction time (Tc) increased from 6% to 50% in vastus lateralis [VL] (p = 0.009) and biceps femoris [BF] (p < 0.001), respectively; whereas radial displacement (Dm) increased for 19% in BF (p = 0.036) and 17% in VL (p < 0.001), respectively. Jumping performance remained unchanged from PRE to POST In addition, athletes rated the lockdown period as a positive event and felt psychologically better during the lockdown, primarily because they spent more time with family members and friends. Although there were no differences in any of the variables describing lower limb muscle power following the two-month lockdown, the altered contractile properties of the assessed muscles suggest suboptimal conditioning of the football players.
Community Insights Regarding COVID-19 Vaccine Uptake Intention versus Hesitancy

Background: It is widely believed that vaccine hesitancy is prevalent. Achievement of COVID-19 vaccination depends upon public willingness towards immunization against this disease. This study aimed at revealing the underlying situation regarding community hesitancy for COVID-19 vaccine. This study was conducted to determine the level of acceptance of COVID-19 vaccine uptake among community and to seek association between socio-demographic factors and various perceptions about COVID-19 vaccine. Methods and Materials: A cross-sectional study was carried out on 390 health-care providers and general Pakistani people of age 20 years and above through non probability snowball sampling. An online questionnaire was used to gather data. The socio-demographic variables along with various concepts regarding intentions to take vaccine as well as hesitancy for the same were tried to bring on the surface. The p-value ≤ 0.05 was considered statistically significant. Results: This study reveals that 61.28% of participants desired to get vaccinated. There was significant association between the desire to get vaccination with participant’s age & occupation (p-value < 0.01). The significant association between the positive views of the health-care providers and the other study subjects (p<0.00) is highly encouraging. The other socio-demographic variables have varied effect on vaccine uptake intentions and hesitancy and require further research on this subject. Conclusion: The study conducted on three hundred & ninety respondents consistently reveals the significant association between the positive views of the health care providers and the other study subjects with the p-values lesser than 0.001. The study concludes that other socio-demographic fabric of the community showed varied effect on COVID 19 vaccine uptake intentions and hesitancy. Recommendation: 1. The broad based qualitative research is strongly recommended in order to better seek the community insights & perceptions regarding this public health issue. The large number of Community people although want to get vaccinated against covid-19, still there is a widespread prevalent doubts about this vaccine as being not so safe for them. Such type of doubts among community necessitate that some counselling sessions be conducted in order to remove uncertainties among common people. Motivations of people need to be raised so as to increase the coverage of covid-19 vaccination.
Polysomnographic survey of sleep architecture in patients with methamphetamine dependence during remission

Introduction Methamphetamine dependence is common in the world. Methamphetamine affects sleep architecture through changes in the monoaminergic activity of the brain. Limited studies investigated the sleep architecture in patients with methamphetamine dependence during prolonged abstinence. Therefore, this study investigated the sleep architecture of methamphetamine ex-users in the remission phase by polysomnography. Material and Methods This was a cross-sectional study conducted during 2015-2017 in Mashhad, Iran. 12 methamphetamine ex-users in early full remission phase were selected from residential treatment centers through the convenient sampling method. The clinical interview was made to confirm the diagnosis and assess the inclusion and exclusion criteria. We performed urine dipstick tests to detect any relapses. Participants underwent a one-night polysomnographic evaluation, voluntarily. The collected data were analyzed by independent sample t-test and chi-square test, using SPSS-16. The level of significance was less than . 05. Results The mean total sleep time of participants was significantly lower than the total sleep period (333.6±79.1 vs. 403.0±52.9 minutes, respectively; p=0.001), leading to a significant low sleep efficiency (75.7±14.4%, p=0.047). Evaluation of rapid eye movement (REM) sleep showed a significant increase in the REM latency compared to the healthy population (p<0.001). Stages 1 and 3 of non-REM sleep were increased compared to the healthy population, too (p<0.001 and p=0.002, respectively). Conclusion Former methamphetamine users continue to experience some long-term abnormalities in sleep architecture a few months after drug cessation
The Impact of Endometriosis on Controlled Ovarian Stimulation Outcome

Endometriosis, a frequent condition in reproductive age women, is also associated with infertility by mechanisms incompletely clarified. The effectiveness of endometriosis treatment for infertility is debated, being possible that in vitro fertilization (IVF) offers a better alternative. The response to controlled ovarian stimulation (COS) is an important predictor of live birth, but it might be affected in endometriosis possibly through a decrease of ovarian reserve. Moreover, the predictive value of anti-mullerian hormone (AMH) for the response to COS could be altered by factors disrupting the AMH production in endometriosis. Therefore, we aim to review the literature regarding the response to COS and the AMH production and their predictive value for COS response in patients with endometriosis.
The Role of Dielectrophoresis for Cancer Diagnosis and Prognosis

Simple Summary Dielectrophoresis (DEP) is a label-free cell manipulation technique based on electrical differences that can be applied to liquid biopsies in the context of cancer prognosis and early diagnosis. In fact, it can overcome the current limitations of other platforms in detecting circulating tumor cells (CTC) in prostate cancer (PC), such as the low number of CTCs detected (less than one CTC/mL of peripheral blood), high-cost and time-consuming means for detection, quantification, isolation and characterization. The aim of this review is to give deep insights into the role of DEP for the diagnosis and prognosis of cancer. Abstract Liquid biopsy is emerging as a potential diagnostic tool for prostate cancer (PC) prognosis and diagnosis. Unfortunately, most circulating tumor cells (CTC) technologies, such as AdnaTest or Cellsearch®, critically rely on the epithelial cell adhesion molecule (EpCAM) marker, limiting the possibility of detecting cancer stem-like cells (CSCs) and mesenchymal-like cells (EMT-CTCs) that are present during PC progression. In this context, dielectrophoresis (DEP) is an epCAM independent, label-free enrichment system that separates rare cells simply on the basis of their specific electrical properties. As compared to other technologies, DEP may represent a superior technique in terms of running costs, cell yield and specificity. However, because of its higher complexity, it still requires further technical as well as clinical development. DEP can be improved by the use of microfluid, nanostructured materials and fluoro-imaging to increase its potential applications. In the context of cancer, the usefulness of DEP lies in its capacity to detect CTCs in the bloodstream in their epithelial, mesenchymal, or epithelial–mesenchymal phenotype forms, which should be taken into account when choosing CTC enrichment and analysis methods for PC prognosis and diagnosis.
Teachers’ Pedagogical Competence in Dealing with Teaching Aids in Tanzania: A Case of a Few Finalist Pre-service Science-teachers

The value of teaching aids in the process of teaching sciences cannot be overstated. The capacity of finalist university pre-service science teachers to incorporate teaching aids into their science classrooms to open up the potential of bringing about the critical features of an intended object into realisation is evaluated in this study. Observations and document reviews were used as data collecting techniques in this descriptive study, and they were used to investigate only 25 student-teachers during their final teaching practice placement. Evidence suggested that the study participants’ ability to select or design teaching aids was low as most of the materials they employed had didactic, structural, and technical concerns. Importantly, the study participants demonstrated significant difficulties in unpacking instructional materials during the science lessons. The study recommended various measures for policy and practice regarding both science teacher-education and science teaching process.
A predictive model for the aggregation of polycyclic aromatic compounds

The physical aggregation of polycyclic aromatic compounds (PACs) is a key step in soot inception. In this work, we set out to elucidate which molecular properties influence the physical growth process and use machine learning to quantitatively relate these features to the propensity of these molecules to physically dimerize with other PACs. To this end, we first develop a dataset of PAC monomers along with their calculated free energies of dimerization emphasizing a set of PACs with a diverse range of properties. First, we augment existing calculations of dimerization energies with our own molecular dynamics simulations enhanced by well-tempered Metadyanmics. We then demonstrate that a machine learning model based on the least absolute shrinkage and selection operator (Lasso) is able to quantitatively learn how molecular features contribute to physical aggregation and predict the free energy of dimerization for new pairs of molecules. The model is able to accurately determine the stability for both homodimerization and heterodimerization cases. Our approach also provides a data driven method to determine the molecular features most important to predicting the dimer stability. From this, we determine that the PAC properties most influential to physical dimerization are size, shape, oxygenation, and presence of rotatable bonds. This work highlights the molecular complexity of the PAC monomers that must be accounted for in order to accurately represent physical aggregation. We anticipate that this approach will allow for more effective modeling of the PAC dimerization process as it facilitates the efficient prediction of dimerization propensity from easily calculable molecular features.
Adipose Triglyceride Lipase in Hepatic Physiology and Pathophysiology

The liver is extremely active in oxidizing triglycerides (TG) for energy production. An imbalance between TG synthesis and hydrolysis leads to metabolic disorders in the liver, including excessive lipid accumulation, oxidative stress, and ultimately liver damage. Adipose triglyceride lipase (ATGL) is the rate-limiting enzyme that catalyzes the first step of TG breakdown to glycerol and fatty acids. Although its role in controlling lipid homeostasis has been relatively well-studied in the adipose tissue, heart, and skeletal muscle, it remains largely unknown how and to what extent ATGL is regulated in the liver, responds to stimuli and regulators, and mediates disease progression. Therefore, in this review, we describe the current understanding of the structure–function relationship of ATGL, the molecular mechanisms of ATGL regulation at translational and post-translational levels, and—most importantly—its role in lipid and glucose homeostasis in health and disease with a focus on the liver. Advances in understanding the molecular mechanisms underlying hepatic lipid accumulation are crucial to the development of targeted therapies for treating hepatic metabolic disorders.
Gene expression of inflammatory immune factors and clinical parameters in diabetes and nondiabetes patients with periodontal disease

Objective: This study evaluated clinical, glucose, and immunological parameters in patients with type 2 diabetes mellitus (DM) compared to those without systemic alterations (NDM), both with generalized chronic periodontitis. Methodology: Twenty-one patients were selected with indications of tooth loss. Surgeries were performed using the Widman flap modified to obtain a gingival collar at 1 mm from the gingival margin. Before the surgical procedure, the following clinical parameters were evaluated: pocket probing depth (PPD), gingival recession (GR), clinical attachment level (CAL), and bleeding on probing (BOP). Fasting glucose levels (FGL) and glycosylated hemoglobin Hba1c (HbA1c) were also assessed. During the surgery, gingival tissue samples were collected and frozen for later laboratorial analysis. The samples were processed to obtain mRNA, cDNA and determine the gene expression of the immune parameters IL-1-β, IL-6, TNF-α, IL-10 and NF-kB by real-time polymerase chain reaction (RT-PCR). Data were analyzed statistically considering p<0.05. Results: The clinical and glucose parameters BOP, FGL, and HbA1c were statistically higher in the DM group. RNAm levels of IL-1β, TNF-α, and NF-kB were higher in the DM group (p<0.05). Conclusion: The presence of diabetes and hyperglycemic status increase the levels of pro-inflammatory immune factors and severity of the periodontal disease.