Miracle-dz/UniFAR-FTUs huggingface dataset:
Not bird-brained: Chickens use prior experience to solve novel timing problems

Despite differences between bird and human brain anatomy, birds have recently demonstrated capacities thought to be uniquely human, including planning and problem-solving. Many avian demonstrations of ‘complex’ behaviors rely on species-specific behavior (e.g., caching, tool use), or use birds who have evolved largely in similarly undomesticated circumstances (e.g., pigeons). In the present experiment, we asked how a species domesticated thousands of years ago, chickens (Gallus gallus domesticus), used past experience to navigate novel problems in the double-bisection task. The double-bisection task which has been used extensively with pigeons, allowing a comparison of signatures of chicken and pigeon performance on the same task. Our findings revealed chickens, like pigeons, show flexible learning that is sensitive to the broader context in which events occur. Further, as with pigeons, our chickens’ patterns of performance could be divided into two distinct categories which may reflect differences in the specific behaviors in which organisms engage during a timing task. Our findings demonstrate remarkable similarity in how chickens and pigeons use past experience to navigate novel problems. Further, these findings add to a growing body of knowledge suggesting the simplest forms of learning common across species–operant and respondent conditioning–are more flexible than is typically assumed.
Long‐term outcomes in patients with chronic lymphocytic leukemia treated with ibrutinib: Focus on hypertension and cardiovascular toxicity

Continuous ibrutinib administration is needed to maintain efficacy in patients with chronic lymphocytic leukemia (CLL) and, as such, long‐term toxicity is a concern. The authors report the 5‐year follow‐up of patients with CLL who received treatment with ibrutinib with a focus on hypertension and cardiovascular toxicities.
Dissecting the contributions of the peripheral chemoreflex and myocardial hypoxia to fetal heart rate decelerations in near‐term fetal sheep

Brief repeated fetal hypoxaemia during labour can trigger intrapartum decelerations of the fetal heart rate (FHR) via the peripheral chemoreflex or the direct effects of myocardial hypoxia, but the relative contribution of these two mechanisms and how this balance changes with evolving fetal compromise remain unknown. In the present study, chronically instrumented near‐term fetal sheep received surgical vagotomy (n = 8) or sham vagotomy (control, n = 11) to disable the peripheral chemoreflex and unmask myocardial hypoxia. One‐minute complete umbilical cord occlusions (UCOs) were performed every 2.5 min for 4 h or until arterial pressure fell below 20 mmHg. Hypotension and severe acidaemia developed progressively after 65.7 ± 7.2 UCOs in control fetuses and 49.5 ± 7.8 UCOs after vagotomy. Vagotomy was associated with faster development of metabolic acidaemia and faster impairment of arterial pressure during UCOs without impairing centralization of blood flow or neurophysiological adaptation to UCOs. During the first half of the UCO series, before severe hypotension developed, vagotomy was associated with a marked increase in FHR during UCOs. After the onset of evolving severe hypotension, FHR fell faster in control fetuses during the first 20 s of UCOs, but FHR during the final 40 s of UCOs became progressively more similar between groups, with no difference in the nadir of decelerations. In conclusion, FHR decelerations were initiated and sustained by the peripheral chemoreflex at a time when fetuses were able to maintain arterial pressure. After the onset of evolving hypotension and acidaemia, the peripheral chemoreflex continued to initiate decelerations, but myocardial hypoxia became progressively more important in sustaining and deepening decelerations.
Systematic review: Psychological/psychosocial interventions for the families of gender diverse youth under 18 years old

Background The aim of this paper is the systematic review of psychological/psychosocial interventions for gender diverse youth under 18 years of age and their families, based on the published protocol: PROSPERO 2020 CRD42020163995. Methods A search strategy was developed using key terms. An electronic literature search was completed using the following data bases (OVID MEDLINE; EBSCO CINAHL; ProQuest MEDLINE; OVID PsycINFO). Only studies published in English between 2001–2021 were included. This review is based on PRISMA guidance. Studies meeting inclusion criteria were quality appraised using the Mixed Methods Assessment Tool (MMAT). Results 8405 studies were independently screened. Four studies met the inclusion criteria for the study. Parents of transgender youth attended between one and 11 psychological/psychosocial group interventions. Parents reported reduced isolation and increased knowledge, which enabled them to advocate for their young person`s needs. Psychological/psychosocial group interventions were creating challenges in terms of group processes, with some parents dominating interactions. Psychological/psychosocial group interventions were positive for parents, but no outcomes were collected for transgender young people. Conclusion More research is required to understand the role of group facilitators, the optimal group size and the number of psychological/psychosocial intervention sessions required.
Semaglutide reduces the risk of major adverse cardiovascular events consistently across baseline triglyceride levels in patients with type 2 diabetes: Post hoc analyses of the SUSTAIN 6 and PIONEER 6 trials

Epidemiological studies have shown that elevated triglycerides (TGs) is associated with higher cardiovascular (CV) risk and may help to identify patients at persistent risk of CV events despite treatment with statins and other evidence-based therapies. Evidence suggests that some, but not all, pharmacological treatments that appear to reduce TGs might also reduce the occurrence of fatal or non-fatal CV events in individuals at high risk. TG-lowering approaches with fibrates have not been shown to be beneficial, while data from the Reduction of Cardiovascular Events with Icosapent Ethyl–Intervention Trial (REDUCE-IT) showed a significant benefit of icosapent ethyl in statin-treated, mild-moderately hypertriglyceridaemic patients with CV disease or diabetes with additional risk factors. Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have a proven benefit in risk reduction of major adverse CV event (MACE; a composite of CV death, non-fatal myocardial infarction [MI] or nonfatal stroke), and have been shown to have a modest effect on TGs, but this has not been characterized across varying TG levels. ​ Semaglutide (Novo Nordisk, Denmark) is a long-acting human GLP-1 analogue approved for the treatment of type 2 diabetes (T2D), available in either a once-weekly (OW) subcutaneous (s.c.) or once-daily (OD) oral formulation. The randomized CV outcome trials SUSTAIN 6 and PIONEER 6 investigated s.c. and oral semaglutide, respectively, versus placebo in participants with T2D and established or at high risk of CV disease. Both trials were similar in population and design. To understand whether GLP-1RAs reduce the risk of MACE in T2D across baseline TG levels, this post hoc analysis investigated the effect of semaglutide versus placebo on the primary endpoint and its components (time to first MACE comprising CV death, non-fatal MI or non-fatal stroke), using pooled data from these two trials categorized by baseline TG levels. To understand if GLP-1RAs affect TG levels in people with T2D, a second analysis investigated the effect on the change in TG levels over time.
Evaluation of the Interactions between Mumps Virus and Guinea Pig

Understanding of mumps virus (MuV) pathogenesis and the immune responses against MuV infection is limited. One of the reasons is the lack of relevant animal models. ABSTRACT Mumps is a highly contagious viral disease that can be prevented by vaccination. In the last decade, we have encountered repeated outbreaks of mumps in highly vaccinated populations, which call into question the effectiveness of available vaccines. Animal models are crucial for understanding virus-host interactions, and viruses such as mumps virus (MuV), whose only natural host is the human, pose a particular challenge. In our study, we examined the interaction between MuV and the guinea pig. Our results present the first evidence that guinea pigs of the Hartley strain can be infected in vivo after intranasal and intratesticular inoculation. We observed a significant viral replication in infected tissues up to 5 days following infection and induction of cellular and humoral immune responses as well as histopathological changes in infected lungs and testicles, without clinical signs of disease. Transmission of the infection through direct contact between animals was not possible. Our results demonstrate that guinea pigs and guinea pig primary cell cultures represent a promising model for immunological and pathogenetic studies of the complex MuV infection. IMPORTANCE Understanding of mumps virus (MuV) pathogenesis and the immune responses against MuV infection is limited. One of the reasons is the lack of relevant animal models. This study explores the interaction between MuV and the guinea pig. We demonstrated that all tested guinea pig tissue homogenates and primary cell cultures are highly susceptible to MuV infection and that α2,3-sialylated glycans (MuV cellular receptors) are being abundantly expressed at their surface. The virus remains in the guinea pig lungs and trachea for up to 4 days following intranasal infection. Although asymptomatic, MuV infection strongly activates both humoral and cellular immune response in infected animals and provides protection against virus challenge. Infection of the lungs and testicles after intranasal and intratesticular inoculation, respectively, is also supported by histopathological changes in these organs. Our findings give perspective for application of guinea pigs in research on MuV pathogenesis, antiviral response, and vaccine development and testing.
Fatal work accidents in Ecuador from 2014 to 2020: How the age of the deceased worker relates to the accidents’ temporal and geographical characteristics

Abstract This article analyzes the relationship between the age of male workers deceased in work accidents and temporal (year, month, day of the week, working shifts), geographic (provinces), and economic sector characteristics in which the accidents occurred in Ecuador between 2014 and 2020. Available data on fatal accidents from the Ecuadorian Social Security Institute (IESS) were collected. The results, which report both frequencies and proportions (rates), indicate that fatal accidents have decreased in the period, although the average age of deceased workers has increased. No significant differences were found regarding the month, day of the week, and work shift, nor in the frequency of accidents or the age of the deceased workers. However, differences were found in terms of geographical areas and sectors of economic activity. This study contributes to the literature as it is the first to analyze the temporal and geographical characteristics of fatal accidents about the age of the deceased worker.
Cross-Subject Tinnitus Diagnosis Based on Multi-Band EEG Contrastive Representation Learning

Electroencephalogram (EEG) is an important technology to explore the central nervous mechanism of tinnitus. However, it is hard to obtain consistent results in many previous studies for the high heterogeneity of tinnitus. In order to identify tinnitus and provide theoretical guidance for the diagnosis and treatment, we propose a robust, data-efficient multi-task learning framework called Multi-band EEG Contrastive Representation Learning (MECRL). In this study, we collect resting-state EEG data from 187 tinnitus patients and 80 healthy subjects to generate a high-quality large-scale EEG dataset on tinnitus diagnosis, and then apply the MECRL framework on the generated dataset to obtain a deep neural network model which can distinguish tinnitus patients from the healthy controls accurately. Subject-independent tinnitus diagnosis experiments are conducted and the result shows that the proposed MECRL method is significantly superior to other state-of-the-art baselines and can be well generalized to unseen topics. Meanwhile, visual experiments on key parameters of the model indicate that the high-classification weight electrodes of tinnitus' EEG signals are mainly distributed in the frontal, parietal and temporal regions. In conclusion, this study facilitates our understanding of the relationship between electrophysiology and pathophysiology changes of tinnitus and provides a new deep learning method (MECRL) to identify the neuronal biomarkers in tinnitus.
Quality Improvement Efforts in VA Community Living Centers Following Public Reporting of Performance

ABSTRACT For two decades, the U.S. government has publicly reported performance measures for most nursing homes, spurring some improvements in quality. Public reporting is new, however, to Department of Veterans Affairs nursing homes (Community Living Centers [CLCs]). As part of a large, public integrated healthcare system, CLCs operate with unique financial and market incentives. Thus, their responses to public reporting may differ from private sector nursing homes. In three CLCs with varied public ratings, we used an exploratory, qualitative case study approach involving semi-structured interviews to compare how CLC leaders (n = 12) perceived public reporting and its influence on quality improvement. Across CLCs, respondents said public reporting was helpful for transparency and to provide an “outside perspective” on CLC performance. Respondents described employing similar strategies to improve their public ratings: using data, engaging staff, and clearly defining staff roles vis-à-vis quality improvement, although more effort was required to implement change in lower performing CLCs. Our findings augment those from prior studies and offer new insights into the potential for public reporting to spur quality improvement in public nursing homes and those that are part of integrated healthcare systems.
Impaired β2-adrenergic endothelium-dependent vasodilation in patients previously hospitalized with coronavirus disease 2019

Aim: The pulse wave response to salbutamol (PWRS) – change in augmentation index (AIx) – provides a means to assess endothelial vasodilator function in vivo. Endothelial dysfunction plays a relevant role in the pathogenesis of hypertension and cardiovascular disease and appears to underlie many of the complications of coronavirus disease 2019 (COVID-19). However, to what degree this persists after recovery is unknown. Methods: Individuals previously hospitalized with COVID-19, those recovered from mild symptoms and seronegative controls with well known risk factors for endothelial dysfunction were studied. To assess the involvement of nitric oxide-cyclic guanosine monophosphate pathway (NO-cGMP) on PWRS, sildenafil was also administrated in a subsample. Results: One hundred and one participants (60 men) aged 47.8 ± 14.1 (mean ± SD) years of whom 33 were previously hospitalized with COVID-19 were recruited. Salbutamol had minimal effect on haemodynamics including blood pressure and heart rate. It reduced AIx in controls (n = 34) and those recovered from mild symptoms of COVID-19 (n = 34) but produced an increase in AIx in those previously hospitalized: mean change [95% confidence interval] −2.85 [−5.52, −0.188] %, −2.32 [−5.17,0.54] %, and 3.03 [0.06, 6.00] % for controls, those recovered from mild symptoms and those previously hospitalized, respectively (P = 0.001). In a sub-sample (n = 22), sildenafil enhanced PWRS (change in AIx 0.05 [−2.15,2.24] vs. −3.96 [−7.01. −2.18], P = 0.006) with no significant difference between hospitalized (n = 12) and nonhospitalized participants (n = 10). Conclusions: In patients previously hospitalized with COVID-19, there is long-lasting impairment of endothelial function as measured by the salbutamol-induced stimulation of the NO-cGMP pathway that may contribute to cardiovascular complications.
Efficacy and safety of percutaneous microwave ablation for adenomyosis in the posterior uterine wall.

OBJECTIVE To evaluate the efficacy and safety of percutaneous microwave ablation (PMWA) for treating adenomyosis in the posterior uterine wall. METHODS Thirty-six patients with symptomatic adenomyosis in the posterior uterine wall who had been subjected to PMWA were retrospectively enrolled in this study. Twenty patients who had no ideal transabdominal puncture path due to the retroverted or retroflexed uterine position were treated with PMWA combined with Yu's uteropexy (Group 1). The other sixteen patients were treated with PMWA only (Group 2). The non-perfused volume (NPV) ratio, symptomatic relief rate, recurrence rate, changes in clinical symptom scores, economic cost, and complications were compared. RESULTS The mean NPV ratio for the thirty-six patients was 90.2±18.3%, and the percentage of patients who obtained complete relief (CR) of dysmenorrhea and menorrhagia was 81.3% (26/32), and 69.6% (16/23) respectively. The recurrence rate was 11.1% (4/36). No major complication was observed. Minor complications included lower abdominal pain, fever, vaginal discharge, nausea, and/or vomiting after ablation, with incidences of 55.6%, 41.7%, 47.2%, and 19.4% respectively. Subgroup analysis showed no significant difference in the median value of NPV ratio, symptomatic relief rate of dysmenorrhea and menorrhagia, changes in clinical symptom scores, recurrence rate and economic cost between the two groups (all p > 0.05). CONCLUSION PMWA is an effective and safe treatment for adenomyosis in the posterior uterine wall. ADVANCES IN KNOWLEDGE This study focused on the ultrasound-guided PMWA treatment for adenomyosis in the posterior uterine wall. Yu's uteropexy, a new ancillary technique allowing safe PMWA for deep posterior uterine wall lesions in retroverted uterus, expanded the indications of PMWA for symptomatic adenomyosis.
Use of a Cationic Emulsion of Latanoprost to Treat Glaucoma Patients with Ocular Surface Disease: A Preclinical Review

Prostaglandin analogue topical medications are one of the most effective therapeutic approaches for the chronic management of glaucoma and ocular hypertension, through the reduction of elevated intra ocular pressure (IOP). While many of the first generations of anti-glaucoma eye drops were preserved with benzalkonium chloride, their repeated use may induce chronic ocular surface toxicity that leads to ocular surface disease (OSD) signs and symptoms. As a result, soft-preservatives and preservative-free formulations have been developed with the goal to avoid the long-term iatrogenic toxicity of the preservative agents. In addition, it has been suggested that OSD and its associated inflammation may negatively impact the efficacy of the IOP-lowering medications, including treatment adherence and compliance. Hence, it may be particularly interesting that glaucoma medications can concomitantly protect and “heal” the ocular surface and its environment while lowering elevated IOP, for the greater benefit of glaucoma patients. The objective of the present review is to briefly present the preclinical data of the cationic oil-in-water emulsion of latanoprost (latanoprost-CE) to shed some light on its mechanisms of action. It overall supports the following hypothesis: the restoration of a healthy ocular surface environment and treatment of the OSD signs and symptoms will allow for an improved elevated IOP reduction and glaucoma management. This would be achieved with a once daily dosing regimen to preserve glaucoma patients' vision, ocular surface, and quality-of-life and wellness.
Preparation of carnation-like Ag-ZnO composites for enhanced photocatalysis under visible light

Carnation-like ZnO was synthesized by the facile precipitation method (at room temperature and in 120 min) to decompose dyes in an aqueous medium. The carnation-like ZnO had a stratified porous structure with a size of about 2–3 μm, its petals had a smooth surface with a thickness of 5–10 nm and a width of about 300–500 nm. Ag-ZnO composites were synthesized using glucose with the assistance of PVP. The morphology of Ag-ZnO composites was almost unchanged compared to ZnO. Where, the Ag nanoparticles in the size range of 5–15 nm were uniformly dispersed on the ZnO petals, improving the catalytic ability of the composites in tartrazine (TA) degradation. The influence of Ag content on catalytic structure and performance of composite was studied. The 5Ag-ZnO sample had the highest BET surface area and pore volume and the lowest gap energy (Eg) among the as-synthesized samples. The 5Ag-ZnO sample proclaimed the degradation efficiency in 70 min of 97.8% and the k ap of 0.031 min−1. The influences of catalyst content, solution pH, and concentration of dye on the photodegradation efficiency of the composite were thoroughly studied. Besides, the photocatalytic activity of the composite was demonstrated by degrading various organic substances and reusability. In addition, it was compared to a metal-semiconductor catalyst of Au-ZnO and semiconductor-semiconductor catalysts of MoS2-ZnO, Cu2O-ZnO, and SiO2-ZnO. The catalytic mechanism under visible light was proposed.
Heavy metals contamination in sediments of Bharalu river, Guwahati, Assam, India: A tributary of river Brahmaputra

This study aimed to assess heavy metals in the surface sediments of the Bharalu river, India. Metal concentrations ranged from 6.65−54.6 mg/kg for Ni, 25.2−250.0 mg/kg for Zn, 83.3−139.1 mg/kg for Pb, and 11940.0−31250.0 mg/kg for Fe. The level of metal contamination was assessed using sediment quality guidelines, geo-accumulation index (Igeo), enrichment factor (EF), pollution Load Index (PLI),Nemerow’s pollution index (PIN), and potential ecological risk index. Pb exceeded the sediment quality guidelines at all sites indicating a potential threat to the river ecosystem. (Igeo) and EF also showed moderate to severe enrichment for Pb. Potential ecological risk (RI) showed low risk in the sediments, and Pb is the major contributor to ecological risk. Overall, pollution indices revealed comparably higher contamination of the sediments in the downstream sites than in the upstream site. PCA and correlation matrix analysis indicated both anthropogenic and natural origins for metals. Among anthropogenic sources, urban discharges and waste dumping could be mainly attributed to metal contamination in the river sediments. These findings may aid in developing future river management methods explicitly aimed at tackling heavy metal pollution to prevent further damage to the river ecosystem.
Neurochemical diversity in the central olfactory pathway of the crustacean Parhyale hawaiensis (Amphipoda): evolutionary implications

In mandibulate arthropods, the primary olfactory centers, termed olfactory lobes in crustaceans, are typically organized in distinct fields of dense synaptic neuropils called olfactory glomeruli. In addition to olfactory sensory neuron terminals and their postsynaptic efferents, the glomeruli are innervated by diverse neurochemically distinctive interneurons. The functional morphology of the olfactory glomeruli is understudied in crustaceans compared with insects and even less well understood and described in a particular crustacean subgroup, the Peracarida, which embrace, for example, Amphipoda and Isopoda. Using immunohistochemistry combined with confocal laser scanning microscopy, we analyzed the neurochemistry of the olfactory pathway in the amphipod Parhyale hawaiensis. We localized the biogenic amines serotonin and histamine as well as the neuropeptides RFamide, allatostatin, orcokinin, and SIFamide. As for other classical neurotransmitters, we stained for γ‐aminobutyric acid and glutamate decarboxylase and used choline acetyltransferase as indicator for acetylcholine. Our study is another step in understanding principles of olfactory processing in crustaceans and can serve as a basis for understanding evolutionary transformations of crustacean olfactory systems.