Miracle-dz/UniFAR-FTUs huggingface dataset:
Improvements in health-related quality of life and function in middle-aged women with chronic diseases of lifestyle after participating in a non-pharmacological intervention programme: A pragmatic randomised controlled trial

Background Musculoskeletal diseases consume a large amount of health and social resources and are a major cause of disability in both low- and high-income countries. In addition, patients frequently present with co-morbid chronic diseases of lifestyle. The area of musculoskeletal disease is restricted by a lack of epidemiological knowledge, particularly in low- and middle-income countries. Objectives This pragmatic randomised controlled trial assessed the benefits of a 6-week physiotherapy intervention for middle-aged women with musculoskeletal conditions compared to usual care. Method A weekly 2-h educational programme utilising a workbook, discussion group and exercise class was presented for the intervention group, while the control group received usual care. The primary outcome was health-related quality of life. Parametric and non-parametric data were used to determine the equivalence between the groups. Results Twenty-two participants were randomised to the intervention and 20 to the control group. The control group demonstrated no within-group improvement in health-related quality of life items, compared to significant improvements in two items in the intervention group. The change in median utility score within the intervention group was twice as large as the change in the control group. With regard to self-efficacy, the intervention group demonstrated significant within-group changes in perceived management of fatigue and discomfort. Conclusion The positive impact of the intervention on the participants suggests that the programme should continue at the clinic in question, but should be presented at a more convenient time for participants who work, as recruitment to the study was less than anticipated. Primary health care systems in South Africa urgently need to put structures in place for effective management of the functional impact of chronic diseases of lifestyle and musculoskeletal conditions. It is time for physiotherapists and possibly other health care professionals to participate in the development of appropriate community level interventions to address the functioning and quality of life of individuals living with the diseases.
Analysis of Mechanically Activated Ion Channels at the Cell-Substrate Interface: Combining Pillar Arrays and Whole-Cell Patch-Clamp

Ionic currents can be evoked by mechanical inputs applied directly at the cell-substrate interface. These ionic currents are mediated by mechanically activated ion channels, where the open probability increases with increasing mechanical input. In order to study mechanically activated ion channels directly at the interface between cells and their environment, we have developed a technique to simultaneously monitor ion channel activity whilst stimuli are applied via displacement of cell-substrate contacts. This technique utilizes whole-cell patch-clamp electrophysiology and elastomeric pillar arrays, it is quantitative and appropriate for studying channels that respond to stimuli that are propagated to an adherent cell via the physical substrate. The mammalian channels PIEZO1, PIEZO2 have been shown to be activated by substrate deflections, using this technique. In addition, TRPV4 mediated currents can be evoked by substrate deflections, in contrast to alternate stimulation methods such as membrane stretch or cellular indentation. The deflections applied at cell-substrate points mimic the magnitude of physical stimuli that impact cells in situ.
New Insights into the Physical Conditions and Internal Structure of a Candidate Proto-globular Cluster

We present ∼0. ″1 resolution (∼10 pc) Atacama Large Millimeter/submillimeter Array observations of a molecular cloud identified in the merging Antennae galaxies with the potential to form a globular cluster, nicknamed the “Firecracker. ” Since star formation has not yet begun at an appreciable level in this region, this cloud provides an example of what the birth environment of a globular cluster may have looked like before stars formed and disrupted the natal physical conditions. Using emission from 12CO(2–1), 12CO(3–2), 13CO(2–1), HCN(4–3), and HCO+(4–3) molecular lines, we are able to resolve the cloud’s structure and find that it has a characteristic radius of 22 pc and a mass of (1–9) × 106 M⊙. We also put constraints on the abundance ratios 12CO/13CO and H2/12CO. Based on the calculation of the mass, we determine that the commonly used CO-to-H2 conversion factor in this region varies spatially, with average values in the range cm−2 (K km s−1)−1. We demonstrate that if the cloud is bound (as is circumstantially suggested by its bright, compact morphology), an external pressure in excess of P/k > 108 K cm−3 is required. This would be consistent with theoretical expectations that globular cluster formation requires high-pressure environments, much higher than typical values found in the Milky Way. The position–velocity diagram of the cloud and its surrounding material suggests that this high pressure may be produced by ram pressure from the collision of filaments. The radial profile of the column density can be fit with both a Gaussian and a Bonnor–Ebert profile. If the Bonnor–Ebert fit is taken to be indicative of the cloud’s physical structure, it would imply the cloud is gravitationally stable and pressure-confined. The relative line strengths of HCN and HCO+ in this region also suggest that these molecular lines can be used as a tracer for the evolutionary stage of a cluster.
Orbital Angular Momentum Waves: Generation, Detection, and Emerging Applications

Orbital angular momentum (OAM) has aroused a widespread interest in many fields, especially in telecommunications due to its potential for unleashing new capacity in the severely congested spectrum of commercial communication systems. Beams carrying OAM have a helical phase front and a field strength with a singularity along the axial center, which can be used for information transmission, imaging and particle manipulation. The number of orthogonal OAM modes in a single beam is theoretically infinite and each mode is an element of a complete orthogonal basis that can be employed for multiplexing different signals, thus greatly improving the spectrum efficiency. In this paper, we comprehensively summarize and compare the methods for generation and detection of optical OAM, radio OAM and acoustic OAM. Then, we represent the applications and technical challenges of OAM in communications, including free-space optical communications, optical fiber communications, radio communications and acoustic communications. To complete our survey, we also discuss the state of art of particle manipulation and target imaging with OAM beams.
Current Harmonic Suppression in Dual Three-Phase Permanent Magnet Synchronous Machine With Extended State Observer

Dual three-phase (DTP) permanent magnet synchronous machines (PMSM) have been utilized in many applications due to their outstanding performance. However, large stator current harmonics limit the further application of the DTP-PMSM due to the low impedance in the harmonic subspace. To solve this problem, this article proposes a current harmonic suppression strategy based on an extended state observer (ESO). A detailed analysis is carried out to demonstrate the disturbance rejection ability and robustness of the proposed method. The theoretical analysis also shows that the ESO strategy outstands the conventional proportional-integral controller and advanced proportional resonance (PR) controller in terms of harmonic reduction. The advantages are verified by simulation and experimental results under different operating conditions. The proposed strategy still works well when considering other factors that may cause harmonic distortion, such as magnetic circuit saturation, saliency ratio, over-modulation of the inverter, the voltage drop caused by electric devices, and dead time. Meanwhile, some limitations are also pointed out. The proposed strategy can also be easily applied to other multiphase PMSM types.
The effects of a community-based walking program on walking ability and fall-related self-efficacy of chronic stroke patients

The objectives of this study were to evaluate the effects of community-based walking training (CWT) on the walking ability and fall-related self-efficacy of chronic stroke patients and compare the effects of CWT to the conventional walking programs in stroke patients. Previous studies focused on walking speed, walking endurance, and balance. However, no studies have examined the changes in fall-related self-efficacy after CWT. In order to achieve purpose of this study, 45 chronic stroke patients, who were hospitalized at National Rehabilitation Center, were randomly divided into the CWT group (CWTG, n=15), the treadmill walking training group (TWTG, n=15), and the control group (CG, n=15). The treatment was conducted 3 times per week (30 min each) for 4 weeks. CWT was carried out by gradually increasing the difficulty level in various environments outside the hospital room. The results revealed that the CWTG was more effective in enhancing the walking ability and fall-related self-efficacy than the TWTG and the CG. These findings demonstrated that the CWTG increased the walking ability and fall-related self-efficacy of chronic stroke patients. Therefore, we suggest that adding CWT to standard rehabilitation might be an effective method for improving walking ability and fall-related self-efficacy in chronic stroke patients.
Detailed injury epidemiology in contemporary dance: a 1-year prospective study of 134 students

Aim We investigated the extent and characteristics of injuries in contemporary dance students. Methods During one academic year, 134 students of Bachelor dance and Bachelor dance teacher from Codarts University of the Arts (Rotterdam, the Netherlands) were prospectively monitored monthly, using the Performing Artist and Athlete Health Monitor which includes the Oslo Sports Trauma Research Centre Questionnaire on Health Problems. Results 130 students were included in the analyses. The response rate of monthly completed questionnaires was 80%. During the academic year, 97% of students reported at least one injury, mental complaint or other health problem. The 1-year injury incidence proportion was 81%. Of these injured students, 58% were substantially injured (ie, problems leading to moderate or severe reductions in training volume or performance or complete inability to participate in activities). The monthly injury proportion (all injuries) ranged from 23% to 43% and for substantial injuries from 6% to 17%. The injury incidence rate per 1000 hours dance exposure was 1.9 (95% CI 1.7 to 2.2). Ankle/foot (30%), lower back (17%) and knee (15%) were the most common sites of injury. Conclusion Contemporary dance students are at high risk for injuries. Injury prevention programmes among contemporary dance students should focus on the ankle/foot, lower back and knee.
Upper-body Wingate test classificatory table for adult judo athletes

The aims of this study were to compare the upper-body Wingate test performance of judo athletes from different weight categories and to create a classificatory table for this test. A total of 179 judo athletes performed an upper-body Wingate test, following standardized recommendations (30-sec duration, and a load equivalent to 0.06 kg/kg of body mass). Absolute and relative peak power (PP) and mean power (MP) were determined. Weight categories were compared through a one-way analysis of variance, followed by Tukey test. The effect size was determined by partial eta squared. There was a large effect of weight category in absolute PP and MP, with lower values for the lighter categories (P<0.05), but it is important to note that absolute PP and MP did not differ (P>0.05) between subsequent weight categories. Moreover, when the relative PP and MP were considered, no significant differences were found (P>0.05). The higher values of PP and MP achieved by heavier judo athletes compared to lighter ones during the upper-body Wingate test is likely related to the higher total muscle mass presented by the first group compared to the later. Indeed, judo athletes from different weight category presented similar relative PP and MP, likely due to the judo training demands as well as consequence of a selection of athletes with the higher potential to develop upper-body anaerobic fitness. Finally, the normative classificatory table created may be useful as a reference in judo athletes’ anaerobic evaluation.
Levelling the Playing Field: A Comprehensive Comparison of Visual Place Recognition Approaches under Changing Conditions

In recent years there has been significant improvement in the capability of Visual Place Recognition (VPR) methods, building on the success of both hand-crafted and learnt visual features, temporal filtering and usage of semantic scene information. The wide range of approaches and the relatively recent growth in interest in the field has meant that a wide range of datasets and assessment methodologies have been proposed, often with a focus only on precision-recall type metrics, making comparison difficult. In this paper we present a comprehensive approach to evaluating the performance of 10 state-of-the-art recently-developed VPR techniques, which utilizes three standardized metrics: (a) Matching Performance b) Matching Time c) Memory Footprint. Together this analysis provides an up-to-date and widely encompassing snapshot of the various strengths and weaknesses of contemporary approaches to the VPR problem. The aim of this work is to help move this particular research field towards a more mature and unified approach to the problem, enabling better comparison and hence more progress to be made in future research.
Fractional Brownian motion in a finite interval: correlations effect depletion or accretion zones of particles near boundaries

Fractional Brownian motion (FBM) is a Gaussian stochastic process with stationary, long-time correlated increments and is frequently used to model anomalous diffusion processes. We study numerically FBM confined to a finite interval with reflecting boundary conditions. The probability density function of this reflected FBM at long times converges to a stationary distribution showing distinct deviations from the fully flat distribution of amplitude 1/L in an interval of length L found for reflected normal Brownian motion. While for superdiffusion, corresponding to a mean squared displacement (MSD) 〈 X 2 ( t ) 〉 ≃ t α with 1 < α < 2, the probability density function is lowered in the centre of the interval and rises towards the boundaries, for subdiffusion (0 < α < 1) this behaviour is reversed and the particle density is depleted close to the boundaries. The MSD in these cases at long times converges to a stationary value, which is, remarkably, monotonically increasing with the anomalous diffusion exponent α. Our a priori surprising results may have interesting consequences for the application of FBM for processes such as molecule or tracer diffusion in the confines of living biological cells or organelles, or other viscoelastic environments such as dense liquids in microfluidic chambers.
Aurora A inhibition limits centrosome clustering and promotes mitotic catastrophe in cells with supernumerary centrosomes

The presence of supernumerary centrosomes is prevalent in cancer, where they promote the formation of transient multipolar mitotic spindles. Active clustering of supernumerary centrosomes enables the formation of a functional bipolar spindle that is competent to complete a bipolar division. Disruption of spindle pole clustering in cancer cells promotes multipolar division and generation of non-proliferative daughter cells with compromised viability. Hence molecular pathways required for spindle pole clustering in cells with supernumerary centrosomes, but dispensable in normal cells, are promising therapeutic targets. Here we demonstrate that Aurora A kinase activity is essential for spindle pole clustering in cells with extra centrosomes. While cells with two centrosomes are ultimately able to build a bipolar spindle and proceed through a normal cell division in the presence of Aurora A inhibition, cells with supernumerary centrosomes form multipolar and disorganized spindles that are not competent for chromosome segregation. Instead, following a prolonged mitosis, these cells experience catastrophic divisions that result in grossly aneuploid, and non-proliferative daughter cells. Aurora A inhibition in a panel of Acute Myeloid Leukemia cancer cells has a similarly disparate impact on cells with supernumerary centrosomes, suggesting that centrosome number and spindle polarity may serve as predictive biomarkers for response to therapeutic approaches that target Aurora A kinase function.
An FTIR Microspectroscopy Ratiometric Approach for Monitoring X-ray Irradiation Effects on SH-SY5Y Human Neuroblastoma Cells

The ability of Fourier transform infrared (FTIR) spectroscopy in analyzing cells at a molecular level was exploited for investigating the biochemical changes induced in protein, nucleic acid, lipid, and carbohydrate content of cells after irradiation by graded X-ray doses. Infrared spectra from in vitro SH-SY5Y neuroblastoma cells following exposure to X-rays (0, 2, 4, 6, 8, 10 Gy) were analyzed using a ratiometric approach by evaluating the ratios between the absorbance of significant peaks. The spectroscopic investigation was performed on cells fixed immediately (t0 cells) and 24 h (t24 cells) after irradiation to study both the initial radiation-induced damage and the effect of the ensuing cellular repair processes. The analysis of infrared spectra allowed us to detect changes in proteins, lipids, and nucleic acids attributable to X-ray exposure. The ratiometric analysis was able to quantify changes for the protein, lipid, and DNA components and to suggest the occurrence of apoptosis processes. The ratiometric study of Amide I band indicated also that the secondary structure of proteins was significantly modified. The comparison between the results from t0 and t24 cells indicated the occurrence of cellular recovery processes. The adopted approach can provide a very direct way to monitor changes for specific cellular components and can represent a valuable tool for developing innovative strategies to monitor cancer radiotherapy outcome.
Fully resonant scalars on asymptotically AdS wormholes

In this work we show the existence of asymptotically AdS wormhole geometries where the scalar probe has an equispaced, fully resonant spectrum, as that of a scalar on AdS spacetime, and explore its dynamics when non-linearities are included. The spacetime is a solution of Einstein-Gauss-Bonnet theory with a single maximally symmetric vacuum. Introducing a non-minimal coupling between the scalar probe and the Ricci scalar remarkably leads to a fully resonant spectrum for a scalar field fulfilling reflective boundary conditions at both infinities. Applying perturbative methods, which are particularly useful for unveiling the dynamics at time scales of order $\varepsilon^{-2}$ (where $\varepsilon$ characterizes the amplitude of the initial perturbation), we observe both direct and inverse energy cascades between modes. This motivates us to explore the energy returns in the case in which the dynamics is dominated by a single mode. We find numerical and perturbative evidence that near exact returns do exist in this regime. We also provide some comments on the fully backreracting case and provide a proof of the universality of the weakly non-linear dynamics around AdS, in the context of Lovelock theories with generic couplings, up to times of order $\varepsilon^{-2}$.
Microbial Quality of Drinking Water and Prevalence of Water-Related Diseases in Marigat Urban Centre, Kenya

Background: Accessibility to potable water is a fundamental right for dignity and well-being. Despite this observation, more than 1.1 billion people lack access to safe drinking water. This is particularly true in the Sub-Saharan Africa and South East Asia regions. Objective: The main aim of this study was to assess microbial quality of drinking water and prevalence of water-related diseases in Marigat town, Baringo County, Kenya. Methods: Samples of drinking water were collected from water sources (boreholes, rivers, and wells) and at the point of use (households) and analyzed for Escherichia coli and total coliform (TC) bacteria using the most probable number method. In situ measurements of pH and temperature were performed using a Wagtech International portable meter. Clinical health records from the local health centers were also reviewed to assess the prevalence rates of some of the water-related diseases. Results: There were significant differences among water sources during dry season for E coli (F2,21 = 3.629, P < .05) and TC (F2,21 = 4.041, P < .05). Similar observations were made during wet season for E coli (F2,21 = 4.090, P < .05) and TC (F2,21 = 1.893, P < .05). Furthermore, there were significant interactions between the water sources and season for E coli (F2,42 = 7.66, P < .01) and TC (F2,42 = 5.494, P < .05). Drinking water in large plastic storage containers (herein referred to as sky-plast) had the highest E coli and TC concentrations. Typhoid was the most prevalent water-related disease during the dry season (10%), whereas diarrhea (3%) was the most prevalent during the wet season. Conclusions and recommendations: All drinking water at abstraction and point of use for Marigat residents are microbiologically contaminated and therefore pose serious health risks to consumers of such water. Thus, there is need for public health awareness campaigns on household water management to curb incidences of water-related diseases. Public health practitioners at county and national levels need to ensure that households have adequate access to potable water and improved sanitation.
Evaluating All Potential Oral Complications of Diabetes Mellitus

Diabetes mellitus (DM) is associated with several microvascular and macrovascular complications, such as retinopathy, nephropathy, neuropathy, and cardiovascular diseases. The pathogenesis of these complications is complex, and involves metabolic and hemodynamic disturbances, including hyperglycemia, insulin resistance, dyslipidemia, hypertension, and immune dysfunction. These disturbances initiate several damaging processes, such as increased reactive oxygen species (ROS) production, inflammation, and ischemia. These processes mainly exert their damaging effect on endothelial and nerve cells, hence the susceptibility of densely vascularized and innervated sites, such as the eyes, kidneys, and nerves. Since the oral cavity is also highly vascularized and innervated, oral complications can be expected as well. The relationship between DM and oral diseases has received considerable attention in the past few decades. However, most studies only focus on periodontitis, and still approach DM from the limited perspective of elevated blood glucose levels only. In this review, we will assess other potential oral complications as well, including: dental caries, dry mouth, oral mucosal lesions, oral cancer, taste disturbances, temporomandibular disorders, burning mouth syndrome, apical periodontitis, and peri-implant diseases. Each oral complication will be briefly introduced, followed by an assessment of the literature studying epidemiological associations with DM. We will also elaborate on pathogenic mechanisms that might explain associations between DM and oral complications. To do so, we aim to expand our perspective of DM by not only considering elevated blood glucose levels, but also including literature about the other important pathogenic mechanisms, such as insulin resistance, dyslipidemia, hypertension, and immune dysfunction.