Miracle-dz/UniFAR-FTUs huggingface dataset:
Development of transverse flow at small and large opacities in conformal kinetic theory

We employ an effective kinetic description, based on the Boltzmann equation in the relaxation time approximation, to study the space-time dynamics and development of transverse flow of small and large collision systems. By combining analytical insights in the small opacity limit with numerical simulations at larger opacities, we are able to describe the development of transverse flow from very small to very large opacities. Suprisingly, we find that deviations between kinetic theory and hydrodynamics persist even in the limit of very large opacities, which can be attributed to the presence of the early pre-equilibrium phase.
Evaluating Presidential Support in the Brazilian House of Representatives Through a Network-Based Approach

Conflicts between the executive and legislative powers are a common, and even expected, characteristic of presidential systems, with some governments being more successful in the activity of obtaining support from the Congress than others. In the case of Brazil, specifically, this factor is considered crucial in the so called"coalition governments", with direct positive or negative consequences for the president, in terms of government performance during his (her) term. In this work, we investigate this problem by testing and comparing two different methods for evaluating the government support in the Brazilian House of Representatives. The first method is a more traditional one, being based on roll-call voting data, and measures the presidential support at the legislators level. The second method uses a network-based approach, and performs the same type of analysis but at the parties level. The obtained results, when applying both methods on legislative data comprising the period from 1998 until 2019, indicate that both methods are valid, with common features being found not only between the results provided by the two of them, but also when comparing their results with those obtained by previous and relevant studies in this field, by using the same type of data but different methodologies.
Aquifer Characterization and Uncertainty in Multi‐Frequency Oscillatory Flow Tests: Approach and Insights

Characterizing aquifer properties and their associated uncertainty remains a fundamental challenge in hydrogeology. Recent studies demonstrate the use of oscillatory flow interference testing to characterize effective aquifer flow properties. These characterization efforts relate the relative amplitude and phase of an observation signal with a single frequency component to aquifer diffusivity and transmissivity. Here, we present a generalized workflow that relates extracted Fourier coefficients for observation signals with single and multiple frequency components to aquifer flow properties and their associated uncertainty. Through synthetic analytical modeling we show that multi‐frequency oscillatory flow interference testing adds information that improves inversion performance and decreases parameter uncertainty. We show increased observation signal length, sampling frequency, and pressure sensor accuracy all produce decreased parameter uncertainty. This work represents the first attempt we are aware of to quantify effective aquifer parameters and their associated uncertainty using multi‐frequency oscillatory flow interference testing.
On inverse problems arising in fractional elasticity

We first formulate an inverse problem for a linear fractional Lam\'e system. We determine the Lam\'e parameters from exterior partial measurements of the Dirichlet-to-Neumann map. We further study an inverse obstacle problem as well as an inverse problem for a nonlinear fractional Lam\'e system. Our arguments are based on the unique continuation property for the fractional operator as well as the associated Runge approximation property.
The course of post-stroke apathy in relation to cognitive functioning: a prospective longitudinal cohort study

ABSTRACT Apathy is common after stroke and has been associated with cognitive impairment. However, causality between post-stroke apathy and cognitive impairment remains unclear. We assessed the course of apathy in relation to changes in cognitive functioning in stroke survivors. Using the Apathy Scale (AS) and cognitive tests on memory, processing speed and executive functioning at six- and 15 months post-stroke we tested for associations between (1) AS-scores and (change in) cognitive scores; (2) apathy course (persistent/incident/resolved) and cognitive change scores. Of 117 included participants, 29% had persistent apathy, 13% apathy resolving over time and 10% apathy emerging between 6-15 months post-stroke. Higher AS-scores were cross-sectionally and longitudinally associated with lower cognitive scores. Relations between apathy and cognitive change scores were ambiguous. These inconsistent relations between apathy and changes in cognition over time suggest that post-stroke apathy does not directly impact cognitive performance. Both these sequelae of stroke require separate attention.
ConCerv: a prospective trial of conservative surgery for low-risk early-stage cervical cancer

Objective The objective of the ConCerv Trial was to prospectively evaluate the feasibility of conservative surgery in women with early-stage, low-risk cervical cancer. Methods From April 2010 to March 2019, a prospective, single-arm, multicenter study evaluated conservative surgery in participants from 16 sites in nine countries. Eligibility criteria included: (1) FIGO 2009 stage IA2–IB1 cervical carcinoma; (2) squamous cell (any grade) or adenocarcinoma (grade 1 or 2 only) histology; (3) tumor size <2 cm; (4) no lymphovascular space invasion; (5) depth of invasion <10 mm; (6) negative imaging for metastatic disease; and (7) negative conization margins. Cervical conization was performed to determine eligibility, with one repeat cone permitted. Eligible women desiring fertility preservation underwent a second surgery with pelvic lymph node assessment, consisting of sentinel lymph node biopsy and/or full pelvic lymph node dissection. Those not desiring fertility preservation underwent simple hysterectomy with lymph node assessment. Women who had undergone an ‘inadvertent’ simple hysterectomy with an unexpected post-operative diagnosis of cancer were also eligible if they met the above inclusion criteria and underwent a second surgery with pelvic lymph node dissection only. Results 100 evaluable patients were enrolled. Median age at surgery was 38 years (range 23–67). Stage was IA2 (33%) and IB1 (67%). Surgery included conization followed by lymph node assessment in 44 women, conization followed by simple hysterectomy with lymph node assessment in 40 women, and inadvertent simple hysterectomy followed by lymph node dissection in 16 women. Positive lymph nodes were noted in 5 patients (5%). Residual disease in the post-conization hysterectomy specimen was noted in 1/40 patients—that is, an immediate failure rate of 2.5%. Median follow-up was 36.3 months (range 0.0–68.3). Three patients developed recurrent disease within 2 years of surgery—that is, a cumulative incidence of 3.5% (95% CI 0.9% to 9.0%). Discussion Our prospective data show that select patients with early-stage, low-risk cervical carcinoma may be offered conservative surgery.
Installation and evaluation of autonomous solar dryer for potato drying in Tarma

In this work, an autonomous and automated solar dryer has been developed to dry potatoes in the town of Tarma at an altitude of 3 040 m in July 2019, which has a solar collector with two reflectors, a drying chamber with a capacity of 20 kg, photovoltaic panel and a control system. The thermal behavior of the no-load solar dryer was studied, achieving increases in the temperature in the drying chamber of up to 50.7 ±7 °C with solar radiation of 880 ±144 W m h. The effect of pretreatment was evaluated with two concentrations of sodium bisulfite (0.02% and 0.03%) and three drying temperatures (50 °C, 55 °C and 60 °C) to evaluate the physical (L), physical-chemical characteristics (acidity, pH) and chemicals (humidity and ash). The results showed a reduction of 70% of the water having a final humidity between 12.56% to 13.85%. Likewise, no significant difference (p> 0.05) was found between the physical, physicochemical, and chemical characteristics at the different bisulfite concentrations and drying temperatures of the Yungay potato. These potato quality parameters are in accordance with the Peruvian standard NTP 011.119 ‘potato and its derivatives: potato, definitions and requirements’, which offers an efficient alternative to dehydrated agricultural products.
The development of narrative skills in monolingual Swedish-speaking children aged 4 to 9: a longitudinal study

Abstract This longitudinal study investigated the development of oral narrative skills in monolingual Swedish-speaking children (N = 17). The MAIN Cat/Dog stories were administered at four timepoints between age 4 and 9. Different narrative aspects were found to develop differently. In story comprehension, the children performed high already at T1 (4;4) and were at ceiling at T2 (5;10), whereas story structure developed significantly until T4 (9;4). Narrative length and syntactic complexity reached a plateau at T3 (7;4). Referent introduction was not mastered until T4. The results suggest that general conclusions regarding the development of narrative skills depend on the specific aspects studied.
Product Prices, Service Quality, Promotion Affect Decisions on Purchasing Motorcycle Parts

This research was motivated by the high number of customer complaints in 2019, higher prices compared to competitors, and the lack of sales targets in the last few months. This research aimed to analyze the effect of price, service quality, and promotion on motorcycle spare parts purchasing decisions. This type of research was a quantitative descriptive study. The population in this research were 1890 customers who purchased genuine Honda spare parts at PT Indako Trading Coy. Sampling using simple random sampling technique, in order to obtain a sample of 237 people. Data collection using a questionnaire method. The data were analyzed using multiple linear regression tests. The results of the research and data analysis showed that partially the product price, service quality, and promotion have a significant influence on the decision to purchase motorcycle spare parts. Hypothesis testing shows that Fcount> Ftable (75.204> 2.64) with a significance of 0.000 <0.05. Based on this, it can be concluded that price, service quality and promotion have a positive and significant effect simultaneously on the decision to purchase motorcycle parts. Copyright © Universitas Pendidikan Ganesha. All rights reserved. A R T I C L E I N F O Article history: Received 18 May 2020 Received in revised form 5 June 2020 Accepted 18 July 2020 Available online 29 August 2020
Yield, biochemical properties and cooking quality traits of sweet potatoes (Ipomoea batatas) as affected by Nitrogen and Potassium Fertilizer rates

This study evaluated the effects of mineral fertilizer rates on biochemical properties, cooking quality traits and root yield of sweetpotatoes. The experimental design was 4 x 4 factorial in randomized complete block with three replications. The treatment factors were four varieties of sweetpotato (Ligri, Bohye, Dadanyuie and Apomuden) and four fertilizer amendments (T1: 3030-30 kg /ha NPK, T2: 30-30-60 kg NPK+50 kg Muriate of Potash, T3: 30-30-90 kg/ha NPK+ 100 kg Muriate of Potash and T4: Control (No fertilizer). Results showed that the fertilizer rates did not influence root yield but variety had significant difference (P<0.05). Apomuden recorded the highest average root yield of 14.5 t/ha which was significantly higher than Ligri 5.1 t/ha. Ligri recorded the highest dry matter and sugar contents of 34.63% and 67.98% respectively while Apomuden recorded the lowest dry matter content and starch content of 23.75% and 50.00% respectively. However, it recorded appreciable amount of beta-carotene and sugar contents of 32.38 mg/100g and 28.04% respectively. There were significant variety × location interactions effect (P < 0.05) on average root yield and biomass yield. The significant varietal response observed in this study implies that choice of variety is an important factor to consider in sweetpotato production.
Panel Optimization for High‐Dimensional Immunophenotyping Assays Using Full‐Spectrum Flow Cytometry

Technological advancements in fluorescence flow cytometry and an ever‐expanding understanding of the complexity of the immune system have led to the development of large flow cytometry panels reaching up to 43 colors at the single‐cell level. However, as panel size and complexity increase, so too does the detail involved in designing and optimizing successful high‐quality panels fit for downstream high‐dimensional data analysis. In contrast to conventional flow cytometers, full‐spectrum flow cytometers measure the entire emission spectrum of each fluorophore across all lasers. This allows for fluorophores with very similar emission maxima but unique overall spectral fingerprints to be used in conjunction, enabling relatively straightforward design of larger panels. Although a protocol for best practices in full‐spectrum flow cytometry panel design has been published, there is still a knowledge gap in going from the theoretically designed panel to the necessary steps required for panel optimization. Here, we aim to guide users through the theory of optimizing a high‐dimensional full‐spectrum flow cytometry panel for immunophenotyping using comprehensive step‐by‐step protocols. These protocols can also be used to troubleshoot panels when issues arise. A practical application of this approach is exemplified with a 24‐color panel designed for identification of conventional T‐cell subsets in human peripheral blood. © 2021 Malaghan Institute of Medical Research, Cytek Biosciences. Current Protocols published by Wiley Periodicals LLC.
Payment schemes and treatment responses after a demand shock in mental health care

Abstract We study whether two groups of mental health care providers—each paid according to a different payment scheme—adjusted the duration of their patients' treatments after they faced an exogenous 20% drop in the number of patients. For the first group of providers, self‐employed providers, we find that they did not increase treatment duration to recoup their income loss. Treatment duration thresholds in the stepwise fee‐for‐service payment function seem to have prevented these providers to treat patients longer. For the second group of providers, large mental health care institutions who were subject to a budget constraint, we find an average increase in treatment duration of 8%. Prior rationing combined with professional uncertainty can explain this increase. We find suggestive evidence for overtreatment of patients as the longer treatments did not result in better patient outcomes, i.e. better General Assessment of Functioning scores.
Ethnic studies increases longer-run academic engagement and attainment

Significance Anti-racist curricula and teaching methods are a potentially potent way for schools to better promote a just society and improve educational outcomes for low-income students and students of color. Ethnic studies (ES) courses in K–12 schools are an increasingly common and prominent example of such culturally relevant and critically engaged practice. Proponents tout the benefits of ES for increasing student engagement and academic outcomes, yet there is little causal evidence supporting these claims. In this study, we use a preregistered regression-discontinuity research design to identify the longer-term impacts on educational attainment and engagement of being assigned to an ES course in grade 9. We find that assignment to ES substantially increased high school graduation, attendance, and the probability of enrolling in college. Increased interest in anti-racist education has motivated the rapidly growing but politically contentious adoption of ethnic studies (ES) courses in US public schools. A long-standing rationale for ES courses is that their emphasis on culturally relevant and critically engaged content (e.g., social justice, anti-racism, stereotypes, contemporary social movements) has potent effects on student engagement and outcomes. However, the quantitative evidence supporting this claim is limited. In this preregistered regression-discontinuity study, we examine the longer-run impact of a grade 9 ES course offered in the San Francisco Unified School District. Our key confirmatory finding is that assignment to this course significantly increased the probability of high school graduation among students near the grade 8 2.0 grade point average (GPA) threshold used for assigning students to the course. Our exploratory analyses also indicate that assignment increased measures of engagement throughout high school (e.g., attendance) as well as the probability of postsecondary matriculation.
Impact of Managerial Competency and Learning Orientation on Job Performance

Amna Niazi, Hafiz Ahmed Faraz, Beenish Arshad, Waheed Asghar Humanities & Social Science Department, University of Engineering & Technology, Lahore, Pakistan, amna.niazi@uet.edu. pk Institute of Business & Management, University of Engineering & Technology, Lahore, Pakistan, ahmad.faraz797@gmail.com FAST School of Management, Lahore, Pakistan, beenish.arshad@nu.edu. pk Director in Technical Education and Vocational Training Authority, Government of the Punjab, Lahore, Pakistan, waheedasgharpk@gmail.com ARTICLE DETAILS ABSTRACT
Online Self-Disclosure and Social Sharing of Emotions of Women with Breast Cancer Using Instagram–Qualitative Conventional Content Analysis

Objectives Women with breast cancer share their experiences and emotions about the illness on Instagram – a tool understudied when it comes to chronic illness. The paper characterizes the women's activities, and both online self-disclosure and social sharing of emotions concepts are used to help explain the women's practices. Methods Using qualitative conventional content analysis, four profiles of women are manually analysed, with posts as the unit of analysis (n = 811). Based on eleven subcategories, three broad analytical categories are introduced: self-disclosure of negative information (C1), self-disclosure of positive information (C2) and disclosure of information about other people (C3). Results The women post narratives about suffering resulting from cancer, and the fears they experience. Also, the posts relate to positive emotions, joyful life events, self-acceptance, or self-affirmation. While writing, the women share information about people supporting them on their way to recovery. Discussion The activity of women cannot be explained only by their online self-disclosure, where anonymity and lack of offline support are often emphasized. Women on Instagram are not anonymous and report on support by relatives and other people. Rimé's concept of social sharing of emotions is used to explain this phenomenon.
Pathway analysis in metabolomics: Recommendations for the use of over-representation analysis

Over-representation analysis (ORA) is one of the commonest pathway analysis approaches used for the functional interpretation of metabolomics datasets. Despite the widespread use of ORA in metabolomics, the community lacks guidelines detailing its best-practice use. Many factors have a pronounced impact on the results, but to date their effects have received little systematic attention. Using five publicly available datasets, we demonstrated that changes in parameters such as the background set, differential metabolite selection methods, and pathway database used can result in profoundly different ORA results. The use of a non-assay-specific background set, for example, resulted in large numbers of false-positive pathways. Pathway database choice, evaluated using three of the most popular metabolic pathway databases (KEGG, Reactome, and BioCyc), led to vastly different results in both the number and function of significantly enriched pathways. Factors that are specific to metabolomics data, such as the reliability of compound identification and the chemical bias of different analytical platforms also impacted ORA results. Simulated metabolite misidentification rates as low as 4% resulted in both gain of false-positive pathways and loss of truly significant pathways across all datasets. Our results have several practical implications for ORA users, as well as those using alternative pathway analysis methods. We offer a set of recommendations for the use of ORA in metabolomics, alongside a set of minimal reporting guidelines, as a first step towards the standardisation of pathway analysis in metabolomics.
Differential role of TNFR1 and TNFR2 in the development of imiquimod‐induced mouse psoriasis

Tumor necrosis factor alpha (TNF) has been implicated in the pathogenesis of psoriasis and anti‐TNF therapeutics are used in the treatment of psoriasis in the clinic. However, considerable proportion of patients fail to respond to anti‐TNF treatment. Furthermore, anti‐TNF therapy induces de novo development of psoriasis in some patients with other type of autoimmune disorders. Therefore, further understanding of the role of TNF‐TNFR signaling in pathogenesis of psoriasis remains a critical to devise safer and more effective treatment. In this study, it is shown that in imiquimod‐induced mouse psoriasis model, TNF receptor type 1 (TNFR1) deficiency inhibited the development of skin diseases. In sharp contrast, TNF receptor type 2 (TNFR2) deficiency led to more severe psoriasis that was associated with increased Th1 and Th17 responses and reduced number of CD4+Foxp3+ regulatory T cells (Tregs). Importantly, adoptive transfer of WT Tregs was able to attenuate inflammatory responses in imiquimod‐treated TNFR2‐/‐ mice, suggestive of a role of malfunctioned Tregs in mice deficient in TNFR2. RNA sequencing data revealed that Tregs deficient in TNFR2 exhibited down‐regulation of different biological processes linked to proliferative expansion. Taken together, our study clearly indicated that TNFR1 was pathogenic in mouse psoriasis. In contrast, through boosting the proliferative expansion of Tregs, TNFR2 was protective in this model. The data thus suggest that TNFR1‐specific antagonist or TNFR2‐specific agonist may be useful in the treatment of patients with psoriasis.
Structural and energetic profiling of SARS-CoV-2 receptor binding domain antibody recognition and the impact of circulating variants

The SARS-CoV-2 pandemic highlights the need for a detailed molecular understanding of protective antibody responses. This is underscored by the emergence and spread of SARS-CoV-2 variants, including Alpha (B.1.1.7) and Delta (B.1.617.2), some of which appear to be less effectively targeted by current monoclonal antibodies and vaccines. Here we report a high resolution and comprehensive map of antibody recognition of the SARS-CoV-2 spike receptor binding domain (RBD), which is the target of most neutralizing antibodies, using computational structural analysis. With a dataset of nonredundant experimentally determined antibody-RBD structures, we classified antibodies by RBD residue binding determinants using unsupervised clustering. We also identified the energetic and conservation features of epitope residues and assessed the capacity of viral variant mutations to disrupt antibody recognition, revealing sets of antibodies predicted to effectively target recently described viral variants. This detailed structure-based reference of antibody RBD recognition signatures can inform therapeutic and vaccine design strategies.