Miracle-dz/UniFAR-FTUs huggingface dataset:
Uncovering the Mechanism of Astragalus membranaceus in the Treatment of Diabetic Nephropathy Based on Network Pharmacology

Background Diabetic nephropathy (DN), characterized by hyperglycemia, hypertension, proteinuria, and edema, is a unique microvascular complication of diabetes. Traditional Chinese medicine (TCM) Astragalus membranaceus (AM) has been widely used for DN in China while the pharmacological mechanisms are still unclear. This work is aimed at undertaking a network pharmacology analysis to reveal the mechanism of the effects of AM in DN. Materials and Methods. In this study, chemical constituents of AM were obtained via Traditional Chinese Medicine Systems Pharmacology Database (TCMSP), and the potential targets of AM were identified using the Therapeutic Target Database (TTD). DisGeNET and GeneCards databases were used to collect DN-related target genes. DN-AM common target protein interaction network was established by using the STRING database. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were carried out to further explore the DN mechanism and therapeutic effect of AM. The network diagrams of the active component-action target and protein-protein interaction (PPI) networks were constructed using Cytoscape software. Results A total of 16 active ingredients contained and 78 putative identified target genes were screened from AM, of which 42 overlapped with the targets of DN and were considered potential therapeutic targets. The analysis of the network results showed that the AM activity of component quercetin, formononetin, calycosin, 7-O-methylisomucronulatol, and quercetin have a good binding activity with top ten screened targets, such as VEGFA, TNF, IL-6, MAPK, CCL3, NOS3, PTGS2, IL-1β, JUN, and EGFR. GO and KEGG analyses revealed that these targets were associated with inflammatory response, angiogenesis, oxidative stress reaction, rheumatoid arthritis, and other biological process. Conclusions This study demonstrated the multicomponent, multitarget, and multichannel characteristics of AM, which provided a novel approach for further research of the mechanism of AM in the treatment of DN.
Effect of L-Methionine Feeding on Serum Homocysteine and Glutathione Levels in Male and Female Wistar Rats

Homocysteine (Hcy) is a critical indicator of cardiovascular disease. High levels of Hcy have now been recognised as a risk factor for the development of a wide range of diseases. Hyperhomocysteinemia (Hhcy) can be induced by methionine or Hcy supplementation. On the other hand, Glutathione (GSH) is a major antioxidant in the body and also an important compound for oxidative defence. It is composed of 3 amino acids: cysteine, glutamate, and glycine. Interestingly, methionine is also a crucial compound in GSH synthesis. This study aims to assess the impact of 1% L-methionine feeding (10 or 30 weeks) on the body weight and serum Hcy and GSH levels of young adult (16 weeks) and middle-aged (36 weeks) Wistar rats of both sexes. Serum was analysed for Hcy and reduced GSH levels by liquid chromatography mass spectrometry (LCMS) in response to 1% L-methionine feeding. One percent L-methionine feeding decreased body weight in all conditions investigated, although this only reached significance in males after 10 weeks supplementation and females after 30 weeks supplementation. It also induced a significant increase in the serum Hcy levels of male Wistar rats, whilst having no significant effect on Hcy serum levels in female rats. Finally, we also observed a small increase in serum GSH levels in female Wistar rats but no change in serum GSH levels in the males. These results suggest that methionine feeding affects body weight homeostasis and alters by products of methionine catabolism.
Characterization and functional analysis of microRNA399 in Cunninghamia lanceolata

The miR399 is a conserved microRNA (miRNA) family, and it has been characterized as an essential regulator of phosphorus transport in plants. However, the biological function of miR399 in Cunninghamia lanceolata is still largely unclear. In this study, the comparison of mature miR399 sequence revealed a high similarity between Arabidopsis thaliana and C. lanceolate, and the pre-miR399 was capable of forming a typical stem-loop hairpin structure. A gene PHOSPHATE 2 (PHO2) was identified as a target of cln-miR399 using 5' rapid amplification of cDNA ends. Furthermore, the relationship between cln-miR399 and PHO2 was further confirmed through a transient co-expression of both genes in Nicotiana benthamiana. To examine the function of miR399 in Arabidopsis, miR399-overexpressing transgenic Arabidopsis thaliana was acquired using Agrobacterium-mediated approach. Real-time PCR showed that the amount of cln-MIR399 transcripts was higher in miR399-overexpressing plants than in wild-type plants, which was accompanied with down-regulation of expression of its target gene AtPHO2. The P content was 1.40 to 1.56-fold higher in the leaves of three transgenic lines than in wild type plants. However, the P content in the roots of the three transgenic lines was 24.5 - 37.2 % less than that in wild type plants. Moreover, the transcriptions of three phosphate transporter genes (PHT1, PHT2, and PHT3) were up-regulated in roots of miR399-overexpressing Arabidopsis plants. Interestingly, the transgenic lines exhibited retarded growth under normal P conditions compared with the wild type. Our findings demonstrate that cln-miR399 may play crucial roles in P transport and plant growth via regulation of its target gene PHO2.
WORK-FAMILY CONFLICT, JOB ENGAGEMENT, EMOTIONAL EXHAUSTION: THEIR INFLUENCE ON THE TURNOVER INTENTION OF INDIGENOUS PAPUAN FEMALE EMPLOYEES

This study presents a model linking work-family conflict (WFC), job engagement, emotional exhaustion, and turnover intention. The primary objective was to investigate the direct effect of work-family conflict on turnover intention and its indirect effect through job engagement and emotional exhaustion. The data were obtained by a questionnaire from a sample of 111 respondents of Papuan Female who work at PT Freeport Indonesia. Data analyzed by used structural equation modeling with PLS-based and found two insignificant paths in models. The result showed that WFC hasa significant effect in improving turnover intention and emotional exhaustion, but have no significant effect in lowering job engagement. Moreover, job engagement does not significantly effect in lowering turnover intention, while emotional exhaustion has a significant effect in increasing job engagement and turnover intention. The mediation test results indicated that job engagement cannot provide an important role, both in the work-family conflict effect on turnover intention, and emotional exhaustion effect on turnover intention. Instead, emotional exhaustion can provide a partial mediating role in the work-family conflict effect on turnover intention, in which this path is one of the important findings with practical implications and the consequences of these findings for future research are further discussed.
The Role of Metformin for Prevention of First Trimesteric Miscarriage in Women With Polycystic Ovary Syndrome: A Randomized Controlled Trial

Background: This study aimed to evaluate the effect of metformin on early pregnancy loss (EPL) in pregnant women with olycystic ovary syndrome (PCOS). Patients and Methods: A randomized clinical trial (Clinicaltrials.gov NCT 02498522) was conducted in Ain-Shams Maternity Hospital in the period between August 2018 and July 2019. One hundred and sixty six women previously diagnosed with PCOS and got pregnant with induction of ovulation in concomitance with Metformin were randomized either Metformin 500 mg orally every 8 hours until the end of the 1st trimester or not receiving Metformin. The primary outcome is to observe any significant decline in the incidence of EPL in PCOS patients after administration of Metformin through out 1st trimester.Results: There was a significant reduction in miscarriage rate after administration of Metformin during 1st trimester. Introduction of Metformin helped pregnancy loss rate to drop to 10.8% while the rate in the group discontinued Metformin was 42.2% (p < 0.05). The side effects rate as nausea, vomiting, gastric irritation and flatulence was significantly higher in the Metformin group.Conclusion: The use of Metformin in patients with PCOS during 1st trimester reduces the incidence of early pregnancy loss (EPL).
MANAGEMENT OF Meloidogyne incognita ON TOMATO BY FOLIAR SPRAYING AMMONIA OR ADDING OLD FARMYARD MANURE, OR Bacillus thuringiensis AS SOIL AMENDMENTS UNDER WIREHOUSE CONDITIONS.

Wire house experiment was conducted to study the impact of three components i.e. protecto, Bacillus thuringiensis (Bt), farmyard manure (FYM) and ammonia at two levels of application each as 0.9& 1.8 g, 42& 63 g; and 30& 60 ml/plant separately where the first two components applied as soil amendments whilst the third one as foliar spraying comparing to oxamyl at the recommended dose on controlling M. incognita infecting tomato cv. 888 or not and plant growth as well under greenhouse conditions during spring seasons of 2011& 2012. Results showed that all tested treatments ameliorated plant growth criteria of the infected and uninfected ones comparing to the checks. Moreover, as the level of farmyard manure and ammonia raised from 42 to 63 g for the former and from 30 to 60 ml/plant separately for the latter as tomato plant height, total plant fresh weight, shoot dry weight, leaves dry matter, total yield of tomato fruit, diameter and number percentage increase values increased for both plant cases of seasons 2011& 2012, respectively comparing to the checks. However, opposite results were recorded within treatment of protecto (Bt) levels. Among the three components with two levels each tested, ammonia at 60 ml/plant as foliar spraying application accomplished the highest percentage increase values that averaged 89.92& 70.2%, 68.9% &59.53%; and 89.7& 75.3%, 75.34& 65.9%; 59.4& 61.1%; 71.1& 51.2%; and 128.9& 132.8%, 90.3& 101.6%; and 90.4& 97.26% for plant height, total plant fresh weight, shoot dry weight, leaves dry matter, total yield tomato fruit, diameter and number for the uninfected plants of two tested seasons 2011& 2012, respectively. Similar trend was observed with the infected plants, where ammonia at 60 ml/plant also surpassed other tested treatments with values that were amounted to 70.68 and 65.44%; 84.0& 75.25%, 124.2& 119.7%; 70.7& 118.4%; 83.8& 62.8%; for the same tomato plant growth characters, respectively comparing to nematode alone for the two seasons 2011& 2012. However, plant receiving protecto (Bt) at the high level (1.8 g/plant) recorded the least values of plant height, total plant fresh weight; shoot dry weight, leaves dry matter, total yield of tomato fruit, and diameter, number, respectively for seasons 2011& 2012 of the infected and uninfected plants.
Commercial microwave links as a tool for operational rainfall monitoring in Northern Italy

Abstract. There is a growing interest in emerging opportunistic sensors for precipitation, motivated by the need to improve its quantitative estimates at the ground. The scope of this work is to present a preliminary assessment of the accuracy of commercial microwave link (CML) retrieved rainfall rates in Northern Italy. The CML product, obtained by the open-source RAINLINK software package, is evaluated on different scales (single link, 5 km×5 km grid, river basin) against the precipitation products operationally used at Arpae-SIMC, the regional weather service of Emilia-Romagna, in Northern Italy. The results of the 15 min single-link validation with nearby rain gauges show high variability, which can be caused by the complex physiography and precipitation patterns. Known sources of errors (e.g. the attenuation caused by the wetting of the antennas or random fluctuations in the baseline) are particularly hard to mitigate in these conditions without a specific calibration, which has not been implemented. However, hourly cumulated spatially interpolated CML rainfall maps, validated with respect to the established regional gauge-based reference, show similar performance (R2 of 0.46 and coefficient of variation, CV, of 0.78) to adjusted radar-based precipitation gridded products and better performance than satellite-based ones. Performance improves when basin-scale total precipitation amounts are considered (R2 of 0.83 and CV of 0.48). Avoiding regional-specific calibration therefore does not preclude the algorithm from working but has some limitations in probability of detection (POD) and accuracy. A widespread underestimation is evident at both the grid box scale (mean error of −0.26) and the basin scale (multiplicative bias of 0.7), while the number of false alarms is generally low and becomes even lower as link coverage increases. Also taking into account delays in the availability of the data (latency of 0.33 h for CML against 1 h for the adjusted radar and 24 h for the quality-controlled rain gauges), CML appears as a valuable data source in particular from a local operational framework perspective. Finally, results show complementary strengths for CMLs and radars, encouraging joint exploitation.
Study of drug utilization trends in respiratory tract infections in a tertiary care teaching hospital: a retrospective study

Drug utilization study defined as marketing, distribution, prescription, and use of drugs in a society, with special emphasis on the resulting medical, social and economic consequences. It plays crucial role in the health sector as it deals with the patterns of prescription, quality, determinants and outcomes of usage of drugs. Ultimately it provides insight into the efficiency of drug use and results of such research can be used to help to set priorities for the rational allocation of health care budgets.
Effect of Educational Intervention on Improvement Of Quality of Life for Children with Epilepsy

Epilepsy is one of a number of neurological disorders that affect quality of life. Nursing intervention of these children is crucial to maintaining their life and improving their quality of life. Therefore, the aim of this study was improve the quality of life for children with epilepsy, through, identifying children & mother's knowledge and practice regarding epilepsy, identifying factors affecting on quality of life for epileptic child, designing and implementing a health educational intervention for mothers to improve quality of life for their children with epilepsy and evaluating the effect of educational intervention on mothers' knowledge and practice to improve quality of life of children with epilepsy. The research hypothesis Mothers after attending the educational intervention will show improvement on their children's quality of life. Setting, the study was conducted at the Student School Health Insurance in Benha. Sample, it involved all children with epilepsy (100) from both sexes, aged 6-15 year and their accompanying mothers recruited for the conduction of the study. The tools of data collection were 1) mothers and child assessment sheet 2) Epilepsy quality of life scale, 3) practice assessment sheet and 4) an educational program. The results showed significant improvement in mothers' knowledge and practice regarding caring for their children with epilepsy, also slightly improvement in children's quality of life after program implementation. The study concluded Tanta Scientific Nursing Journal Vol. 5 No. 2 November, 2013 80 that a success in improving the mothers' knowledge and practice regarding epilepsy. After three months of implementation the program the mothers' knowledge and practice was decline but still higher than before the program regarding all items of knowledge and practice, improving in all items of quality of life after 3 month of program implementation. The study recommended enhancing child's quality of life through periodical educational program and follow-up and regular educational programs at the out patient clinics about epilepsy and how to deal with
Assess Nurses’ Knowledge and Attitude for Patient Safety in Cardiac Catheterization Unit

Background: Patient safety is a major component of healthcare quality, which is defined as the avoidance of causing harm to patients in providing healthcare services. The cardiac catheterization is a procedure that allows a cardiologist to get firsthand information about the patterns of blood pressure and blood flow inside the heart. Aim of the study to assess nurses knowledge and attitude for patient safety in cardiac catheterization unit. A Descriptive research design was adopted to conduct this study. The study was conducted in cardiac catheterization unit at Heart Hospital, Assuit University. Subjects The study included 40 nurses working in mentioned setting. Tools: A structured interview sheet was conducted, structured into three parts included personal data, nurses' knowledge and nurses' attitude for patient safety. Results: It was found that all of nurses (100%) had poor knowledge for patient safety. While (77.5%) of nurses had negative attitude and (22.5%) of them had positive attitude toward patient safety in cardiac catheterization unit. Conclusion: it was concluded that nurses in cardiac catheterization unit had poor knowledge and negative attitude for patient safety. Recommendations: Educational program should be done for nurses in cardiac catheterization about patient safety to improve their knowledge and attitude for patient safety.
IMPROVING SAFFLOWER (Carthamus tinctorius L.) GROWTH AND BIOLOGICAL ACTIVITIES UNDER SALINE WATER IRRIGATION BY USING IRON AND ZINC FOLIAR APPLICATIONS

The present study aimed to evaluate growth and biological activities ofSafflower Carthamus tinctorius L. treated with Iron and Zinc foliar applicationunder Irrigation with saline water at Wadi El-Natrown, El-Behera Governate Egypt during two winter seasons; 2011/ 2012 and 2012/ 2013. It aimed to find out the individual and combination effects of foliar application of Iron (Fe) and Zinc (Zn) on vegetative growth, reproductive and yield characters, in addition to some chemical constituents of Safflower plants. All the vegetative growth characters; plant height, number of primary and secondary branches were significantly affected by the foliar application. Foliar application by Zn at 0.6% significantly promoted the plant height followed by application by the combination between Fe: Zn at 0.3:0.6%. The later treatment gave the greatest number of primary and secondary branches followed that of Zn at 0.6% where there was no significant difference between the two treatments. The highest number of inflorescences and seed yield per plant or plot or fadd was obtained by using the combination between Fe : Zn at a ratio of 0.3:0.6% or by Zn only at 0.6%. The percentage of Zinc, Iron, lipid, protein and pigments in addition to biological activity in different plant treatment were determined. All of chemical parameters were significantly affected by Zn, Fe foliar application at different concentration.
Influence of the Period of Abstinence on Semen Quality in a Patient with Systemic Lupus Erythematosus: A Case Report and Review of the Literature

Systemic lupus erythematosus (SLE) is a chronic inflammatory disease that can affect fertility. There is currently little information regarding the semen profile of males with SLE. Moreover, there is no consensus on an appropriate period of sexual abstinence for semen analysis and on the use of DNA fragmentation assay, together with multiple semen analyses to document the semen profile in this clinical population. In this case report, multiple semen analyses, with DNA fragmentation assays, were performed for a male with SLE undergoing fertility treatment at our andrology unit. A 4-day period of abstinence improved the semen concentration, total sperm count, total progressive motile sperm, and sperm morphology, with minimal DNA fragmentation. In conclusion, multiple semen analyses obtained after different periods of sexual abstinence, together with DNA fragmentation assays, may be useful to develop a semen profile for patients with SLE, providing information on the optimal abstinence period to yield the best semen quality for subsequent fertility treatment. For patients with fluctuating semen results, concomitant semen cryopreservation should be considered to preserve the better quality semen before starting assisted reproductive technologies if pregnancy is planned in the future.
Calculating the Power Demand in Turning of AISI 316L Stainless Steel Through the

Austenitic stainless steel AISI 316L has been widely used for orthopedic implants due to its mechanical properties, corrosion resistance and biocompatibility. Machining of austenitic stainless steel are often regarded as 'difficult to machine' and classed a single group of steels, based on experience with the most common austenitic types. This paper presents a methodology for practical calculation of power demand based on cutting force that will be compared with experimental results especially turning process. Based on a previously proposed definition, the power demand in metal cutting is the energy required cutting. This paper provides a complete list of mathematical expressions needed for the calculation of power demand and demonstrates their utility for turning operation of austenitic stainless steel using coated and uncoated carbide. Keywords—cutting force; power Demand; turning; stainless steel
Single-Stage Posterior Hemivertebra Resection with Transpedicular Instrumented Fusion for Correction of Congenital Scoliosis

Background Data: Congenital scoliosis may be caused by failure of formation, failure of segmentation, or by a combination of these 2 factors, resulting in a mixed deformity. Complete failure of formation results in a hemivertebra. There is a debate on the method of treatment and whether operate with or without fusion. Nevertheless there is no debate about the early treatment. Congenital scoliosis due to hemivertebra is difficult to control and may progress after non-operative and even after operative management. Hemivertebra resections in older children often require a long fusion segmentbecause of secondary structural curves that may be avoided with early management. Purpose: Assessment of surgical intervention in congenital scoliosis by posterior approach with transpedicular instrumentation. Study Design: Retrospective clinical case study. Patients and Methods: Thirty five consecutive cases of congenital scoliosis in young children were operated on by hemivertebra resection by a posterior-only approach with transpedicular instrumentation. Meanage at time of surgery was eight years. The mean follow-up was 26 months. Results: Mean Cobb angle of the main curve was 55.8° before surgery, and 13° at latest follow-up. On average three segments were fused. There was one infection, two pedicle fractures, and three implant failures. In two patients additional operations were performed because of new developing deformities. Conclusion: Correction surgery of congenital scoliosis should be performed early,before the development of severe local deformities and secondary structural changes, especially in patients with expected deterioration. Posterior resection of the hemivertebra with transpedicular instrumentation allows for early intervention in young children. Excellent correction in the frontal and sagittal planes, and a short segment of fusion allows for normal growth in the unaffected parts of the spine. (2016ESJ115)