Quantum Chemical Computational Method for finding the Survival and Hazard rate for a demonstration of ovarian pituitary feedback loop in women

The objective of this study was to do a comparative study of Follicular and letual phase of inhibins, estrogen, progesterone, LH and FSH. For women in both phases, levels of inhibin A, inhibin B, estradiol and progesterone decreased after the removal of the ovaries. Correlation analysis showed that inhibin , estrogen were significantly negatively correlated in both phases with FSH concentration. Inhibin had negatively correlated in follicular phase and progesterone had a negative correlation in the luteal phase. In this paper we consider the exponentiated Weibull family which has a scale parameter and two shape parameters for the application part. The Weibull family and the exponentiated exponential family are the particular cases of this family. The distribution has been compared with the two-parameter Weibull and Gamma distributions with respect to failure rates. This study showed that ovarian inhibin A and B were cleared from the circulation within 12 h of oophorectomy, whereas E2 and progesterone remain in the circulation for longer. Negative correlation between FSH, inhibin suggests that inhibins may contribute to the observed early rise in FSH after the surgical menopause. © 2017 Elixir All rights reserved. Elixir Appl. Math. 106 (2017) 46897-46901 Applied Mathematics Available online at www.elixirpublishers. com (Elixir International Journal) S.Lakshmi and K.Sheeja / Elixir Appl. Math. 106 (2017) 46897-46901 46898 Thus the failure rate of EW behaves more like the failure rate of the Weibull distribution than the Gamma distribution. 3. Applications Dimeric inhibins and activins were initially characterized as gonadal glycoprotein hormones regulating Pituitary FSH secretion. In addition to the ovary there are reports confirming extragonadal sources (e.g. adrenal, bone marrow, placenta, embryonic tissue, pituitary) of inhibin/activin subunits and follistatin mRNA expression [9]. In reproductive ageing , circulating concentrations of inhibin decreases with increasing age and disappear after menopause in women. This is evidence that the ovary produces inhibins. Previous studies have shown that, after bilateral oophorectomy, in cycling women levels of FSH rise earlier than H, suggesting that FSH is more sensitive to ovarian feedback [1]. Metabolic clearance studies show that secretion rates of FSH and H are higher during the follicular phase than during the luteal phase of the cycle [3,8]. Yen and Tsai reported that immediately after the surgical removal of the ovaries, FSH and LH concentrations rose rapidly in the follicular phase whereas in the luteal phase concentrations rose slowly [16]. The net increase in serum FSH was higher than that in serum H after surgery in both phases of the cycle [15]. In reproductive ageing , there is no clear relationship between increasing FSH and circulating estrogen until the menopause. In this study we investigate the endocrine mechanis involved in the rapid rise in FSH at the menopause induced by surgery. The gradual decline in circulating inhibins in the years preceeding the menopause, their absence in post-menopause women and the reduction of inhibins that is significant after bilateral oophorectomy are indications that ovaries are the predominant source of circulating inhibins in pre-menopausal women[2,3]. The objectives on this study is to confirm the source of inhibin in cycling women and their disappearance after the removal of the source; and to study the endocrine feedback relationship between FSH, inhibins, estrogen and progesterone at surgical menopause. 3(a) Follicular phase Mean inhibin A and inhibin B levels were 11 4 and 173.5 46 pg/ml respectively in the early follicular phase. Inhibin A and inhibin B levels decreased rapidly and were below the limit of detection after 12 h [inhibin A<2 pg/ml (P < 0.05) and inhibin B 16 pg/ml] of bilateral oophorectomy in women who had surgery in their early follicular phase (day 3–8; Figure 1a). Mean serum E2 level was 0.171 0.06 nmol/l in the patients. Estradiol levels fell rapidly within the first 6 h of surgery and then levels were stable after 6 h (0.028–0.042 nmol/l) until the end of the study period (Figure 1b). Mean progesterone level was 3.76 0.84 nmol/l in the early follicular phase patients. Inhibins in menopause Serum progesterone levels were not significantly altered for the first 6 h and then levels decreased until the end of the study (0.48 0.1 nmol/l) (P < 0.001; Figure 1b). Mean serum FSH was 6.3 1.6mIU/ml; the levels did not significantly change until 6 h post surgery, after which there was a 2-fold rise between 12 and 24h followed by a progressive rise throughout the 3 day study period. By the end of the study, mean FSH had risen by ~5 fold (P< 0.01, Figures 1c and 2a). There was a trend of rising LH levels after 24 h of surgery (Figures 1c and 2b) that was not significant. Figure 1a.