Miracle-dz/UniFAR-FTUs huggingface dataset:
Prevalence, risk factors and genotype distribution of Toxoplasma gondii DNA in soil in 1 China

In the present study, we performed a cross-sectional survey to determine the occurrence and 27 genotype distribution of T. gondii DNA in soil samples collected from different sources from 28 six geographic regions in China. Between March 2015 and June 2017, 2100 soil samples were 29 collected from schools, parks, farms and coastal beaches, and examined for T. gondii DNA 30 using three PCR assays targeting 529-bp repeat element (RE) sequence, B1 gene and ITS-1 31 gene sequences. Also, we investigated whether geographic region, soil source and type, and 32 sampling season can influence the prevalence of T. gondii DNA in the soil. Soil samples 33 collected from farms and parks had the highest prevalence, whereas samples collected from 34 school playgrounds and coastal beaches had the lowest prevalence. PCR assays targeting 529- 35 bp RE and ITS-1 gene sequences were more sensitive than the B1 gene-based assay. Positive 36 PCR products were genotyped using multi-locus PCR-RFLP, and ToxoDB #9 was the 37 predominant genotype found in the contaminated soil samples. Multiple logistic regression 38 identified factors correlated significantly with the presence of T. gondii DNA in the soil to be 39 the source of the soil, including farms (odds ratio 3.10; 95% confidence interval [CI], 1.52 to 40 6.29; p = 0.002) and parks (2.59; 95% CI 1.28 to 5.27; p = 0.009). These results show that 41 Chinese soil hosts T. gondii of the most prevalent genotype in China (ToxoDB#9) and that the 42 soil type influences infection patterns. 43 this study to (i) identify T. gondii oocyst's DNA in soil samples and 72 compare infection prevalence and genotype distribution in six different geographic regions in 73 China and (ii) identify the possible risk factors associated with soil contamination with T. gondii oocyst's DNA. Comparative analysis of the soil samples was performed using three PCR-based 75 assays, targeting 529-bp RE, B1 gene and ITS-1 region of rDNA gene, for the detection of T. gondii oocyst DNA in soil samples. The study shows that 10.9% of the tested soil samples from 77 various regions in China contained T. gondii DNA, which may pose a risk to humans.
NDT_A_276708 2695..2705

Department of Psychiatry, Erenkoy Mental Health and Neurological Diseases Training and Research Hospital, University of Health Sciences, Istanbul, Turkey Background and Objectives: Compliance and maintenance of abstinence is a major issue in substance use disorders. Adverse effects of opioid maintenance treatments (OMT) include sexual dysfunctions. There is a vast amount of studies regarding sexual adverse effects of conventional OMTs; however, information regarding buprenorphine/naloxone (Bup/Nal) combination is limited, mostly evaluated in western populations and controversial. In this study, we aimed to assess the sexual adversities of Bup/Nal treatment in a Turkish alcohol and substance use disorder treatment center sample. Materials and Methods: We recruited 100 subjects continuing sublingual Bup/Nal combination and 35 control subjects. Subjects were evaluated via the the Golombok-Rust Inventory of Sexual Satisfaction (GRISS) for sexual dysfunction and for erectile dysfunction (ED) with the International Index of Erectile Function-5 (IIEF-5) as a comparison. Results: The mean dose of our treatment was 9.05. Overall sexual dysfunction scores were not significantly different in between groups with GRISS. ED and noncommunication scores were significantly higher in the Bup/Nal treatment group than the control group (p = 0.002, p = 0.02, respectively). Along with the increased ED scores in GRISS, IIEF-5 total scores also revealed more significant severity of the ED in the Bup/Nal group (p = 0.001). Conclusion: Buprenorphine/naloxone combination lead to a higher degree of ED severity than the non-treatment controls. Noncommunication seems to play a role as a risk factor for ED in patients with opioid use disorder. Thus, effective communication can be a key factor for sexual assertivity and disclosing the sexual adverse effects to the clinicians as well as staying in the treatment.
OP-BRCM210084 1..17

Eighty-five percent of multiple sclerosis cases begin with a discrete attack termed clinically isolated syndrome, but 37% of clinically isolated syndrome patients do not experience a relapse within 20 years of onset. Thus, the identification of biomarkers able to differentiate between individuals who are most likely to have a second clinical attack from those who remain in the clinically isolated syndrome stage is essential to apply a personalized medicine approach. We sought to identify biomarkers from biochemical, metabolic and proteomic screens that predict clinically defined conversion from clinically isolated syndrome to multiple sclerosis and generate a multi-omics-based algorithm with higher prognostic accuracy than any currently available test. An integrative multi-variate approach was applied to the analysis of cerebrospinal fluid samples taken from 54 individuals at the point of clinically isolated syndrome with 2–10 years of subsequent follow-up enabling stratification into clinical converters and non-converters. Leukocyte counts were significantly elevated at onset in the clinical converters and predict the occurrence of a second attack with 70% accuracy. Myo-inositol levels were significantly increased in clinical converters while glucose levels were decreased, predicting transition to multiple sclerosis with accuracies of 72% and 63%, respectively. Proteomics analysis identified 89 novel gene products related to conversion. The identified biochemical and protein biomarkers were combined to produce an algorithm with predictive accuracy of 83% for the transition to clinically defined multiple sclerosis, outperforming any individual biomarker in isolation including oligoclonal bands. The identified protein biomarkers are consistent with an exaggerated immune response, perturbed energy metabolism and multiple sclerosis pathology in the clinical converter group. The new biomarkers presented provide novel insight into the molecular pathways promoting disease while the multi-omics algorithm provides a means to more accurately predict whether an individual is likely to convert to clinically defined multiple sclerosis.
E cacy and Complications of Regional Citrate Anticoagulation During Continuous Renal Replacement Therapy in Critically Ill Patients with COVID-19

Dmytro Khadzhynov (  dmytro.khadzhynov@charite.de ) Charite Universitatsmedizin Berlin https://orcid.org/0000-0001-5462-5776 Uwe von dem Berge Charite Universitatsmedizin Berlin Campus Charite Mitte: Charite Universitatsmedizin Berlin Frédéric Muench Charite University Hospital Berlin: Charite Universitatsmedizin Berlin Stoyan Karaivanov Charite University Hospital Berlin: Charite Universitatsmedizin Berlin Roland Koerner Charite University Hospital Berlin: Charite Universitatsmedizin Berlin Jan M. Kruse Charité Universitätsmedizin Berlin: Charite Universitatsmedizin Berlin Daniel Zickler Charité Universitätsmedizin Berlin: Charite Universitatsmedizin Berlin Klemens Budde Charité Universitätsmedizin Berlin: Charite Universitatsmedizin Berlin Kai-Uwe Eckardt Charité Universitätsmedizin Berlin: Charite Universitatsmedizin Berlin Lukas J. Lehner Charité Universitätsmedizin Berlin: Charite Universitatsmedizin Berlin
Distribution and abundance of breeding and moulting Brant on Banks Island, Northwest Territories, 1992–1994

Aerial surveys were conducted over most (28 414 km 2 ) of southern Banks Island, Northwest Territories, to determine the distribution and abundance of breeding and non-breeding Brant Branta bernicla . In 1992–1993, we estimated that there was an average population of 8745 ± 1115 (standard error) adult Brant on the study area. Taking into account the low densities of Brant that existed in unsurveyed parts of the island, we estimated that at least 10 000 adults were present. Brant were found nesting throughout the study area, including the interior of the island, where earlier observers had not recorded them. The greatest numbers (6455 ± 1007) and densities (0.52/km 2 ) of Brant were found on the western lowlands. Both numbers and densities were considerably lower in the interior and eastern parts of the island. We estimated that there were 116 nesting colonies present on the study region and possibly as many as 130 colonies on all of Banks Island during 1993 (a good nesting year). The total population in the two areas (the western lowlands and the interior/eastern parts of the island) surveyed in both 1992 and 1993 remained stable. However, the proportion of Brant observed in nesting colonies increased from 6% to 32% between 1992 and 1993, the proportion occurring as dispersed pairs declined from 40% to 22%, and the proportion occurring in flocks of non-breeders decreased from 54% to 47%. These changes can probably be attributed to the much earlier spring in 1993. In 1992 and 1993, brood surveys were conducted in a 252-km 2 area in the western lowlands. The number of broods observed was small; although brood and gosling densities appeared to be higher in 1993 (0.20 broods/km 2 , 0.34 goslings/km 2 ) than in 1992 (0.07 broods/km 2 , 0.20 goslings/km 2 ), the differences were not statistically significant (P > 0.05). Brant the study
COPD_A_325211 2983..2996

1Department of Pneumology and Critical Care Medicine, University of Heidelberg, Heidelberg, Germany; 2Division of Pulmonary, Critical Care and Sleep Medicine, National Jewish Health, Denver, CO, USA; 3Institute of Applied Health Research, University of Birmingham, Birmingham, England; 4Pulmonology Department, Centro Hospitalar Universitário do Porto, Porto, Portugal; 5Department of Pulmonary and Infectious Diseases, Hannover Medical School, Hannover, Germany; 6Department of Internal Medicine and Pneumology, University Hospital Marburg, Marburg, Germany Abstract: Alpha 1 Antitrypsin deficiency (AATD) is a hereditary condition characterized by low serum Alpha 1 Antitrypsin (AAT) levels and a predisposition towards early-onset emphysema. Infusion of AAT is the only disease-modifying therapy that can sufficiently raise plasma AAT levels above the putative protective threshold and reduce the decline in lung density loss. Several randomized controlled trials (RCTs) and registry studies support the clinical efficacy of AAT therapy in slowing the progression of AATD-related emphysema and improving survival outcomes. The COVID-19 pandemic has prompted physicians to develop additional strategies for delivering AAT therapy, which are not only more convenient for the patient, but are “COVID-19 friendly”, thereby reducing the risk of exposing these vulnerable patients. Intravenous (IV) self-administration of AAT therapy is likely to be beneficial in certain subgroups of patients with AATD and can remove the need for weekly hospital visits, thereby improving independence and well-being. Increasing the awareness of self-administration in AATD through the development of formal guidelines and training programs is required among both physicians and patients and will play an essential role, especially post-COVID-19, in encouraging physicians to consider self-administration for AATD in suitable patients. This review summarizes the benefits of AAT therapy on the clinical endpoints of mortality and quality of life (QoL) and discusses the benefits of self-administration therapy compared with conventional therapy administered by a healthcare professional. In addition, this review highlights the challenges of providing AAT therapy during the COVID-19 pandemic and the potential considerations for its implementation thereafter.
The Schwarz Lemma

PART I: The classical Schwarz lemma A Schwarz lemma for plurisubharmonic functions The Poincare distance on the unit disc Schwarz-Pick systems of pseudodistances Hyperbolic manifolds Special domains Pseudometrics defined using the (complex) green function Holomorphic curvature The algebraic metric of Harris PART II: A holomorphic characterization of Banch spaces containing CO] Fixed point theorems The analytic Radon-Nikodym property References Index
DDDT_A_295215 2969..2978

1Biotechnology Research Unit, AO of Cosenza, Cosenza, Italy; 2Hematology and Bone Marrow Transplant Unit, Hemato-Oncology Department, Augusta Victoria Hospital, East Jerusalem, Israel; 3HCNR-IBIM, Clinical Epidemiology and Physiopathology of Renal Diseases and Hypertension of Reggio Calabria, Reggio, Calabria, Italy; 4Hematology Unit, AO of Cosenza, Cosenza, Italy; 5Humanitas Clinical and Research Center-IRCCS, Rozzano, Milan, Italy; 6Hematology, Fondazione Cà Granda IRCCS Policlinico, Milan, Italy; 7Stem Cell Transplant Program, Clinical Section, Department of Hemato-Oncology and Radiotherapy, Grande Ospedale Metropolitano “Bianchi-Melacrino-Morelli”, Reggio, Calabria, Italy; 8IRCCS Ospedale Policlinico San Martino, Genoa, Italy; 9Department of Oncology and Hematooncology, University of Milan, Milan, Italy Abstract: Despite recent therapeutic advances, multiple myeloma (MM) patients experience relapses as they become resistant to various classes and combinations of treatment. Melphalan (L-PAM) is an ageless drug. However, its use in the autologous stem cell transplantation (ASCT) setting and the innovative quadruplet regimen as well as daratumumab, bortezomib, and prednisone make this old drug current yet. Melflufen is a peptideconjugated alkylator belonging to a novel class of compounds, representing an overcoming of L-PAM in terms of mechanism of action and effectiveness. The improved melflufen cytotoxicity is related to aminopeptidase activity, notably present in normal and neoplastic cells and remarkably heavily overexpressed in MM cells. Upon entering a cell, melflufen is cleaved by aminopeptidases, ultimately releasing the L-PAM payload and eliciting further the inflow and cleavage of the conjugated peptide. This virtuous loop persists until all extracellular melflufen has been utilized. The aminopeptidase-driven accumulation results in a 50-fold increase in L-PAM cell enrichment as compared with free alkylator. This condition produces selective cytotoxicity, increased on-target cell potency, and decreased offtarget cell toxicity, ultimately overcoming resistance pathways triggered by previous treatments, including alkylators. Due to its distinct mechanism of action, melflufen plus dexamethasone as a doublet, and in combination with other novel drugs, has the potential to be beneficial for a broad range of patients with relapsed/refractory (RR) MM in thirdor even in second-line therapy. The safety profile of melflufen has been consistent across studies, and no new safety concerns have been identified when melflufen was administered in doublet and triplet combinations. Based on growing clinical evidence, melflufen could be not only a good addition in the fight against RRMM but also a drug with a very favorable tolerability profile.
Application of DFT Spreading to OFDM Based WLAN for Energy Efficiency Improvement

— This paper describes an application of Discrete Fourier Transform (DFT) spreading to Orthogonal Frequency Division Multiplexing (OFDM) based wireless LAN (WLAN) to reduce Peak to Average Power Ratio (PAPR) for energy efficiency improvement and to maintain robustness to DC offset error for cost-effective hardware implementation. We call our proposed scheme null DC sub-carrier DFT spreading OFDM, where the DC sub-carrier is made null by splitting the spectrum in the frequency domain after DFT spreading of the modulated signals. The computer simulation results confirm that BER performance is not degraded due to DC offset error at the transmitter and/or the receiver like OFDM with null DC sub-carrier and its PAPR is lower than OFDM, and is almost the same as the conventional DFT spreading OFDM.
Non-deterministic dynamics of a mechanical system. Physical Statistical, Nonlinear, and Soft

A mechanical system is presented exhibiting a non-deterministic singularity, that is, a point in an otherwise deterministic system where forward time trajectories become non-unique. A Coulomb friction force applies linear and angular forces to a wheel mounted on a turntable. In certain conﬁgurations the friction force is not uniquely determined. When the dynamics evolves past the singularity and the mechanism slips, the future state becomes uncertain up to a set of possible values. For certain parameters the system repeatedly returns to the singularity, giving recurrent yet unpredictable behaviour that constitutes non-deterministic chaotic dynamics. The robustness of the phenomenon is such that we expect it to persist with more sophisticated friction models, manifesting as extreme sensitivity to initial conditions, and complex global dynamics attributable to a local loss of determinism in the limit of discontinuous friction.
Human Amniotic Membrane Graft used in Vestibuloplasty: A Case Report

Various grafting materials have been used for vestibuloplasty but all have met with variable results. Skin and mucosal grafts have disadvantages of need of second surgical site, limited amount of mucosa available for grafting, postoperative pain and risk of surgical complications at donor site. In contrast, Human Amniotic Membrane (HAM) does not have limitations as conventional grafts. Its several unique properties forge it as a suitable substitute for conventional skin and mucosal grafts. Aim of this article is to present a case report on treatment for vestibuloplasty using an amniotic membrane graft. We concluded that amniotic membrane can be used successfully as a mucosal graft substitute.
Using molecular sizes of simple sequence repeats versus discrete binned data in assessing probability of ancestry: Application to maize hybrids

The first two authors contributed equally to methodological development and to the application of the methods. ABSTRACT Most inferential methods for profiling genotypes based upon the use of DNA fragments use molecular-size data transcribed into discrete bins, which are intervals of DNA fragment sizes. Categorizing into bins is labor intensive with inevitable arbitrariness that may vary between laboratories. We describe and evaluate an algorithm for determining probabilities of parentage based on raw molecular-size data without establishing bins. We determine the standard deviation of DNA fragment size and assess the association of standard deviation with fragment size. We consider a pool of potential ancestors for an index line that is a hybrid with unknown pedigree. We evaluate the identification of inbred parents of maize hybrids with simple sequence repeat data in the form of actual molecular sizes received from two laboratories. We find the standard deviation to be essentially constant over the molecular weight. We compare these results with those of parallel analyses based on these same data that had been transcribed into discrete bins by the respective laboratories. The conclusions were quite similar in the two cases, with excellent performance using either binned or molecular-size data. We demonstrate the algorithm’s utility and robustness through simulations of levels of missing and mis-scored molecular-size data.
Factors Explaining Medication Adherence of Older Adults with Hypertension: A Cross-sectional Study

: Medication adherence plays a crucial role to control hypertension especially in older adults who are confronted with several challenges to effective pharmacotherapy. However, medication adherence in older people varies widely because of the influence of many factors. This study examined the factors of medication regimen complexity, physical function, social support, health literacy, patient-provider communication, health belief, and self-efficacy in explaining medication adherence of older people with hypertension. Three hundred people aged 60 years and older diagnosed with hypertension were recruited from outpatient departments of four hospitals in Vietnam. Nine questionnaires were used for collecting data: a demographic data form, Hill-Bone Compliance Scale, Medication Regimen Complexity Index, Lawton Instrumental Activities of Daily Living Scale, Multidimensional Scale of Perceived Social Support, Short-Form Health Literacy Questionnaire, Communication subscale of the Interpersonal Processes of Care Survey, Health Belief for Hypertensive Patient Scale, and Medication Adherence Self-Efficacy Scale-Revised. Data analysis was conducted using descriptive statistics, Pearson’s correlation, and hierarchical regression analysis. The results indicated that self-efficacy, appropriate health belief, patient-provider communication, and medication regimen complexity jointly and significantly explained 39.9% of the variation in medication adherence. This finding suggests that nurses can develop interventions to enhance medication adherence by improving communication between patients and healthcare providers, providing instructions to clarify patients’ understanding regarding hypertension and medication, and increasing their confidence in medication administration. Pacific Rim Int J Nurs Res 2020; 24(3) 306-320
PRBM_A_306443 595..620

1School of Accounting, Dongbei University of Finance and Economics, Dalian, People's Republic of China; 2College of Finance, Nanjing Agricultural University, Nanjing, People's Republic of China; 3School of Business Administration, Dongbei University of Finance and Economics, Dalian, People's Republic of China Introduction: This study aims to explore the effects of the behavior of chief executive officers (CEOs) within family firms on investment in research and development (R&D). We also investigate the effect of CEOs’ psychological attributes of overconfidence on R&D investment and the moderating effect between the types of CEOs and R&D investment. Methods: We obtained data on Chinese A-share firms from China Stock Exchange and Accounting Research from 2010 to 2018 for analysis. Then, we used the ordinary least squares model for regression results; moreover, the Tobit regression, GMM and firm fixed effect model are applied to check the robustness of the results. Results: Family CEOs with actual control rights are more open to R&D investment, whereas those without actual control rights exhibit negative behavior. The study found that nonfamily CEOs exhibit insignificant results and negative predicted signs toward R&D investment. Moreover, the results show that overconfident CEOs are more inclined to amplify innovation. Furthermore, results on the moderating effects of CEO psychological attribute of overconfidence indicate that the CEO overconfidence mitigates the negative relationship between family CEOs with actual control rights and R&D investment. However, no moderating effect is found between family CEOs without actual control and R&D investment. The CEO psychological attribute behavior is positive between non-family CEOs and R&D investment. Discussion: This novel study explores the behavioral effect of different types of family firm CEOs on R&D investment. This study will assist corporate board members to make more informed decisions about retaining (or bringing back) family CEOs (with or without actual control rights) or hiring non-family CEOs.