Miracle-dz/UniFAR-FTUs huggingface dataset:
Toll-Like Receptor 4 Mediated Oxidized Low-Density Lipoprotein-Induced Foam Cell Formation in Vascular Smooth Muscle Cells

Background: Oxidized low-density lipoprotein (oxLDL) induced a foam-cell like phenotype of the vascular smooth muscle cells (VSMCs), leading to the inflammatory responses incorporating Toll-like receptors (Tlrs)-mediated cellular alterations. We previously found that Tlr4 participated in inflammation response in VSMCs under oxLDL stimulation. However, the role of Tlr4 in foam-cell formation and underlying molecular pathways has not been comprehensively elucidated. This study aimed to investigate the role of Tlr4-mediated mechanisms in oxLDL induced foam-cell formation within VSMCs. Methods: After incubated with different dose of oxLDL, the lipid, reactive oxygen species (ROS) accumulation and foam-cell phenotype of the VSMCs were detected. The alteration of Tlr family, ROS and lipid accumulation regulators including the Src kinase, Nox2, Nox4, Mnsod and sirtuins were measured. Then the Tlr4 was knock down and underlying cellular change and altered molecules were detected. Results: We showed that oxLDL induced foam-cell like phenotype in VSMCs and led to lipid and ROS accumulation in a dose-dependent manner. OxLDL induced the strongest upregulation of Tlr4 in the Tlrs family and initiated change of Src activation, Nox2, Mnsod, sirt1 and sirt3 expression. The effect of oxLDL was abolished by Tlr4 knockdown. Furthermore, knocking down of Tlr4 reduced Src activation and led to restored Sirt1/Sirt3 expression. Moreover, inhibiting or knocking down the Src kinase diminished lipid accumulation in VSMCs under oxLDL treatment. And overexpression of Sirt1/3 relieved the oxLDL induced ROS accumulation and foam-cell phenotype in VSMCs.Conclusions: These results demonstrated that Tlr4 is a critical regulator in oxLDL induced foam cell formation of VSMCs via mediating Src kinase as well as Sirt1 and Sirt3. Beyond the role of Tlr4 in inflammation response of VSMCs, we provide an integrated mechanism about TLR4 in VSMCs phenotype transition under oxLDL stimulation.
Developing a Single-Item General Self-Efficacy Scale: An Initial Study

General self-efficacy represents the global sense of personal capability across various situations and tasks. The aim of the present study was to develop and validate a single-item general self-efficacy scale which balances practical demands and psychometric concerns. The psychometric properties of the proposed Single-Item General Self-Efficacy Scale (GSE-SI) were examined among 231 Singaporean adults. Results based on three statistical methods demonstrated good reliability (.594 .607 and .726, respectively, M = .642), as compared with the reliability scores from other single-item scales. It also showed satisfactory criterion-related validity evidence (i.e., correlation with a multiple-item general self-efficacy scale, r = .795). Validity evidence based on relationships with other constructs was supported by the correlations between the scores of general self-efficacy and the scores of six relevant constructs (i.e., positive correlations with life satisfaction and positive emotions, negative correlations with negative emotions, task and perceived stress, and illness symptoms). More importantly, the GSE-SI and multiple-item scale scores showed consistent correlation patterns with their relevant constructs. Both GSE-SI and multiple-item scale scores significantly discriminated between the three clusters in a similar pattern. The present results show that the GSE-SI is a reliable and valid measure of general self-efficacy and can be recommended in future research to complement the constraints of multiple-item scales.
ANALISIS FAKTOR-FAKTOR YANG MEMPENGARUHI NON MUSLIM MENJADI NASABAH BANK SYARIAH MANDIRI DI MEDAN

The purpose of this study is to see how big the influence of facilities, promotions and products affect the non muslim community to become a customer Bank Syariah Mandiri. The data used in this research is the primary data is obtained from the division of a detailed questionnaire to the customer self service rich Islamic Bank on Jl. Jend Achmad Yani no.100 Medan. Sampling method used by researchers is a non probability sampling is a technique where each member of the sample on the take the population has the same opportunity to become a member of sampling. Sample technique uptake of engineering purposive sampling ( Judgment Sampling ) is The sampling technique based on the assessment of the characteristics of sample members who adjusted with the goal of researchers. Data analysis method used is the rank spearmant test with SPSS 16 tools. Based on the results factors that most strongly affects non Muslim become cust.omers in Bank Syariah Mandiri is a potent influence 0,370 promotions, both 0,529 products have potent influences and who was last 0,469 facilities had an influence that is.
Causal linkages between supply chain management practices and performance: A balanced scorecard strategy map perspective

Purpose – Today, supply chain design and management constitute a major source of competitive advantage for firms. The purpose of this paper is to empirically investigate, from a balanced scorecard strategy map (BSSM) perspective, the types of linkages through which supply chain management practices (SCMPs) impact on financial and non-financial performance, and consequently lead to the achievement of the firm’s strategic objectives. Design/methodology/approach – This study is carried out in two stages. First, based on the survey data collected from 450 French industrial firms (with a return rate of 20.2 per cent), structural equation modelling (SEM) is used to test eight hypotheses that are formulated through the discussion of previous theoretical and empirical findings in extant literature. Then, based on the framework of the BSSM, the SEM results are used to discuss the linkages between SCMPs and firm performance. Findings – After confirming some of the relationships already observed in extant literature.
A Data Assimilation Algorithm: the Paradigm of the 3D Leray-α Model of Turbulence

In this paper we survey the various implementations of a new data assimilation (downscaling) algorithm based on spatial coarse mesh measurements. As a paradigm, we demonstrate the application of this algorithm to the 3D Leray- α subgrid scale turbulence model. Most importantly, we use this paradigm to show that it is not always necessary that one has to collect coarse mesh measurements of all the state variables, that are involved in the underlying evolutionary system, in order to recover the corresponding exact reference solution. Speciﬁcally, we show that in the case of the 3D Leray- α model of turbulence the solutions of the algorithm, constructed using only coarse mesh observations of any two components of the three-dimensional velocity ﬁeld , and without any information of the third component, converge, at an exponential rate in time, to the corresponding exact reference solution of the 3D Leray- α model. This study serves as an addendum to our recent work on abridged continuous data assimilation for the 2D Navier-Stokes equations. Notably, similar results have also been recently established for the 3D viscous Planetary Geostrophic circulation model in which we show that coarse mesh measurements of the temperature alone are suﬃcient for recovering, through our data assimilation algorithm, the full solution; viz. the three components of velocity vector ﬁeld and the temperature. Consequently, this proves the Charney conjecture for the 3D Planetary Geostrophic model; namely, that the history of the large spatial scales of temperature is suﬃcient for determining all the other quantities (state variables) of the model.
Foundations I

The chapter studies the so-called doctrines of universal faith, developed in chapter XIV of the Tractatus theologico-politicus. The theoretical truth or falsity of such doctrines is irrelevant to their purpose. They only serve to structure the collective religious imagination of common people according to a certain practical standard which consists in the exercise of justice and charity alone. It is, however, still necessary that those who profess doctrines of faith should believe them to be true in order for them to fulfill their practical purpose. This insight prompts Spinoza to break with the model of doctrinal minimalism otherwise favored by tolerationist thinkers in his intellectual context. Contrary to them, he maintains that the so-called adiaphora play a significant role in ensuring that people embrace true religion. The argument is at the heart of Spinoza’s cautious and in some respects conflicted defense of religious pluralism.
The Competition for Industry Research Funding: How Satisfied Are University Commercial Research Clients?.

Constrained public funding for universities and the emphasis placed on university-industry interactions mean that universities are increasingly required to compete for industrial funds for research. This in turn means that universities need to develop a customer service culture in order to be competitive and attractive to industry. Many studies examine industry-university relationships, their importance and ways to improve interactions but publications examining customer service quality in the context of the provision of university research services or technology transfer services to industry are lacking. This article recommends a modified SERVQUAL (service quality survey instrument) approach and the survey results identify several opportunities for improved service delivery practice.
The Influence of HRM Practices on Innovative Work Behavior: a Systematic Literature Review

s were tested for the inclusion criteria. When the abstracts met the inclusion criteria the introduction, methodology, and the discussion part were read and summarized in a table with headings regarding research title, type of research, which HRM practices were considered, how they may have impact on IWB, which results were found by the author(s), in which journal the article is published, and how high the impact factor is for that journal. In the table, the articles are presented in an alphabetical order by the first authors’ name. Through this summary, an open coded valuation was executed leading to an inductive content analysis. As mentioned before, this approach is appropriate, due to this study being of high exploratory nature that aims at composing an integrated framework (Saunders et al., 2007). The initial search (step 1) with the search terms “innovative work behaviour (IWB)”, “employee innovative behaviour”, “individual innovation”, “HRM practice”, and “human resource management” (HRM) revealed in total 796 articles. Hereof, Google Scholar provided 549 articles, Scopus delivered 126 articles, and ISI Web of Knowledge offered 121 articles. In step 2 all articles were checked on redundancies, which resulted in 73 articles being sorted out. In step 3 the abstracts of the remaining 723 articles were checked regarding the inclusion criteria, leading to a removal of another 645 articles, with now 78 articles remaining. Of these articles, the introduction, methodology, and discussion section was checked in detail regarding the inclusion criteria (step 4). After step 4, 50 more articles were removed. This selection left 28 articles that entirely met the inclusion criteria. Figure 2 gives an overview of the process of data extraction.
Executive summary

chestjournal.org BACKGROUND: Low-dose chest CT screening for lung cancer has become a standard of care in the United States, in large part because of the results of the National Lung Screening Trial (NLST). Additional evidence supporting the net benefit of low-dose chest CT screening for lung cancer, and increased experience in minimizing the potential harms, has accumulated since the prior iteration of these guidelines. Here, we update the evidence base for the benefit, harms, and implementation of low-dose chest CT screening. We use the updated evidence base to provide recommendations where the evidence allows, and statements based on experience and expert consensus where it does not.
Characterizing Local Contact Resistances of Interdigitated Back Contact Silicon Solar Cells

Next generation high efficiency interdigitated back contact (IBC) silicon solar cells are often designed with complex doping and contacting structures that are sensitive to series resistance induced losses. Particularly local contact resistance problems present a major fill factor loss in industrially feasible solar cell designs. In this work, we use advanced two dimensional device simulations to understand the impact of globally and locally deteriorated electron and hole contacts on a typical IBC design. For a set of examples, the effect of an increased contact resistance on the global current voltage characteristic is compared to the signature of a simulated local series resistance image using luminescence imaging. Consistent interpretations and quantitative agreement between global and local analysis are shown. We find that the local series resistance of IBC cells react identically for globally altered electron and hole contact resistances. However, locally deteriorated electron and hole contact resistances do not impact fill factor losses identically. Together with qualitative interpretation of luminescence images, these findings present valuable information for IBC cell manufacturers for understanding their cell design's sensitivity to local contact resistance or broken finger problems on fill factor and short-circuit current.
Creatinine Reduction Ratio Is a Prognostic Factor for Acute Kidney Injury following Cardiac Surgery with Cardiopulmonary Bypass: A Single-Center Retrospective Cohort Study

Acute kidney injury (AKI) after cardiac surgery is a common complication that can lead to death. We previously reported that the creatinine reduction ratio (CRR) serves as a useful prognostic factor for AKI. The primary objective of this study was to determine the predictors of AKI after surgery. The secondary objective was to determine the reliability of the CRR for short- and long-term outcomes. We retrospectively collected information about cardiac surgery patients who underwent cardiopulmonary bypass. Patients were divided into AKI and non-AKI groups based on the AKIN and RIFLE criteria. We analyzed the two groups regarding the preoperative patient data and operative information. The CRR was calculated as follows: (preoperative creatinine—postoperative creatinine)/preoperative creatinine. The prognostic factors of AKI-CS were surgery time, CPB time, aorta clamp time, platelet transfusion, and CRR < 20%. In the multivariate logistical analysis, CRR was an independent predictor of AKI (adjusted odds ratio: 0.90 [0.87–0.93], p < 0.001). However, there were no significant differences in CRR in terms of the rate of new onset chronic kidney disease (CKD). After cardiac surgery with cardiopulmonary bypass, CRR has good diagnostic power for predicting perioperative AKI. However, we cannot use it as a prognostic factor over a long-term period.
Charcot-Marie-Tooth Disease as a Risk Factor for Periprosthetic Fractures in Tibiotalocalcaneal Fusion With Intramedullary Nailing

Introduction The treatment for severe fixed hindfoot osteoarthritis secondary to Charcot-Marie-Tooth disease (CMT) is tibiotalocalcaneal (TTC) arthrodesis. In our centre, we have noticed a disproportionate rate of periprosthetic fractures in CMT patients following TTC arthrodesis with retrograde hindfoot nailing. The aim of this study was to test this hypothesis by evaluating our local cohort of TTC arthrodesis with retrograde hindfoot nailing. Methods A retrospective review of patients who had TTC arthrodesis with intramedullary nailing was conducted over a seven-year period. Results There were 45 patients (30 male, 15 female) in our cohort. Forty-one patients achieved radiological and clinical fusion of their TTC arthrodesis. All three patients who had CMT sustained periprosthetic fracture at the tip of the nail at an average of four (range: 2.5-6) months from index operation. In comparison, no patients in the rest of the cohort sustained periprosthetic fractures. The nail position of the patients with CMT was central in both planes in all three patients. None of the patients with CMT had abutment of the cortex on either plane. Conclusion We found that there was a disproportionate rate of periprosthetic fractures in CMT patients in our cohort of TTC arthrodesis with retrograde hindfoot nailing. This suggests that CMT is a significant risk factor. The authors propose a longer nail to reduce the lever arm, with a long period of protected weight bearing till union, followed by consideration of elective removal of the nail to prevent this phenomenon from occurring.
Natural Capitalism: Creating the Next Industrial Revolution

Previous industrial revolutions made people 100 times more productive when low per-capita output was limiting progress in exploiting a seemingly boundless natural world. Today we face a different pattern of scarcity: abundant people and labor-saving machines, but diminishing natural capital. Natural capital refers to the earth’s natural resources and the ecological systems that provide vital life-support services to society and all living things. These services are of immense economic value; some are literally priceless, since they have no known substitutes. Yet current business practices typically fail to take into account the value of these assets—which is rising with their scarcity. As a result, natural capital is being degraded and liquidated by the very wasteful use of resources such as energy, materials, water, fiber, and topsoil. The next industrial revolution, like the previous ones, will be a response to changing patterns of scarcity. It will create upheaval, but more importantly, it will create opportunities. Natural capitalism is a new business model that enables companies to fully realize these opportunities. The journey to natural capitalism involves four major shifts in business practices, all vitally interlinked: • Radically increase the productivity of natural resources. Through fundamental changes in both production design and technology, farsighted companies are developing ways to make natural resources—energy, minerals, water, forests—stretch 5, 10, even 100 times further than they do today. The resulting savings in operational costs, capital investment, and time can help natural capitalists implement the other three principles. • Shift to biologically inspired production models and materials. Natural capitalism seeks not merely to reduce waste but to eliminate the very concept of waste. In closed-loop production systems, modeled on nature’s designs, every output either is returned harmlessly to the ecosystem as a nutrient, like compost, or becomes an input for another manufacturing process. Industrial processes that emulate the benign chemistry of nature reduce dependence on nonrenewable inputs, make possible often phenomenally more efficient production, and can result in elegantly simple products that rival anything man-made. • Move to a “service-and-flow” business model. The business model of traditional manufacturing rests on the sale of goods. In the new model, value is instead delivered as a continuous flow of services—such as providing illumination rather than selling light bulbs. This aligns the interests of providers and customers in ways that reward them for resource productivity. • Reinvest in natural capital. Capital begets more capital; a company that depletes its own capital is eroding the basis Synopsis
Effect of vam fungi and applied phosphorus through stcr precision model on growth, yield and nutrient dynamics in maize in an acid alfisoil

The Inoculation of three VAM cultures viz. local culture (Glomus mosseae), VAM culture from IARI, New Delhi (Glomus mosseae) and a culture from The Energy Research Institute (TERI), New Delhi (Glomus Intraradices) alone or with increasing applied phosphorus levels from 25 to 75% of recommended P2OS based on soil test crop response (STCR) precision model improved the plant height, shoot and root dry matter accumulation, root length and root weight density as well as yield attributes of ralnfed maize in an acid alflsol of NW Himalayas. It was revealed that sole application of any of 3 VAM fungi did not have pronounced effect on phenologlcal stages though combined application of VAM cultures with increasing P levels from 25 to 75% of recommended P2O5 reduced the days to various phenologlcal stages, it was reported that sole application of these 3 VAM cultures improved the maize grain yield by 17.10 to 25.36% over control. Increase in P levels from 25 to 75% of recommended P2O5 besides VAM inoculation resulted in consistent and significant Improvement In grain, stover and biological yield of maize. 75% of recommended P2O5 alongwith VAM cultures achieved the goal of targeted yield (40 q ha"1) of maize, thus, saving the applied P to the tune of about 25% without Impairing the soil fertility in the present study.
Total Rugby: Fifteen Man Rugby for Coach and Player

Part 1 Background to the game: the meaning of total rugby understanding the game team selection. Part 2 Practical coaching: basic coaching techniques the structured session. Part 3 Basic preparation: stretching intensive handling practices resistance exercises. Part 4 Personal skills: the importance of personal skills the ball in your hands the ball on the ground the ball in the air the ball in the opponents' hands cyclic exercises. Part 5 Unit techniques - the forwards: scrummaging back row at the scrummage - attack and defence line-out supporting, mauling and bucking. Part 6 Unit techniques - the backs: half-back play three quarters in attack - spinning the ball, moves, flair kicking. Part 7 Team defence: team defence. Part 8 Team practices: varieties of team practice unit v unit practices unopposed rugby tactical guidelines. Part 9 Fitness for rugby
Untargeted and Targeted Proteomic Analysis of the Impact of Diabetes Mellitus on Two Adipose Tissue Depots and Blood of Obese Patients

Background: Obesity has increased over the last years and it is one of the most common cardiovascular risk factors. In addition obesity is associated with the development of other metabolic disorders such as insulin resistance and type-2 diabetes mellitus (T2DM). Here, we have investigated two adipose tissue depots (AT) proteome and secreted serum proteins in obese patients to understand fat tissue characteristics in metabolic syndrome and T2DM.Methods: We used an untargeted proteomic approach to compare white AT of subcutaneous (SAT) and visceral (VAT) depots in type 3 obese patients. In silico analysis and bioinformatics were applied to proteomic data to gain systems biology information. By bead-based targeted multiplex assay system, we simultaneously detected and quantified multiple targets in qualified complex samples and analyzed the changes produced in the adipokine serum composition due to obesity and T2DM.Results: Protein composition in SAT and VAT showed significant differences. There was upregulation of proteins related with the endocrine regulation system in SAT, whereas proteins upregulated in VAT were related to metabolic disorders. VAT protein composition was more sensitive to the presence of diabetes than SAT. A pro-inflammatory state, caused by the secretion of cytokines and related adypokines, was observed in the serum protein composition of both obese and diabetic patients.Conclusions: Our results show a synergic alteration in the metabolic and inflammatory state in both VAT and serum due to the presence of diabetes, whereas changes in SAT were related with endocrine regulation.