Miracle-dz/UniFAR-FTUs huggingface dataset:
The South American Society of Cardiology (SSC) and the Latin American Association of Cardiac and Endovascular Surgery (LACES) Statement on the 2021 ACC/AHA/SCAI Guidelines for Coronary Artery Revascularization

1Centro Cardiovascular Universitario, Universidad de la Republica del Uruguay, Montevideo, Uruguay. 2Division of Cardiovascular Diseases, Pontificia Universidad Católica de Chile, Santiago, Chile. 3Cardiovascular Surgery Discipline, Hospital São Paulo, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, São Paulo, Brazil. 4Centro Médico Medicina Externa S.A. (MEDEX), San Isidro, Peru. 5Faculdade de Medicina, Centro Universitário Fundação Assis Gurgacz, Cascavel, Paraná, Brazil. 6Cardioayuda Ltda. y Sociedad Colombiana de Cardiología y Cirugía Cardiovascular, Bogotá, Colombia. 7University Clinic for Cardiac Surgery, Leipzig Heart Center, Leipzig, Germany. 8Seguro Integral de Salud (SINEC) – Seguridad Social y Unidad de Diagnóstico Médico (UDIME), Santa Cruz de la Sierra, Bolivia.
The Effects of Racial Diversity in Citizen Decision-Making Bodies

Many citizen decision-making bodies, from juries to boards, have the potential to represent racial minority views because they must deliberate and decide unanimously. However, little is known about the effects of racial diversity on group decisions. Existing studies use observational data, include too few people of color (POCs), or cannot disentangle race and preferences. We study one such body, the civil jury, which can check economic actors whose actions disproportionately affect minoritized populations. We analyze 2,694 citizens randomly assigned to 449 mock juries tasked with deciding punitive damages against corporations. The number of POCs on a jury affects private opinions, even accounting for other group and individual characteristics. However, group decisions are less affected, because POC dissenters carry less influence than White dissenters: POCs can change minds more easily than votes. Deliberation and veto power do not eliminate racial barriers to substantive representation.
Rate of Involved Endocervical Margins According to High-Risk Human Papillomavirus Subtype and Transformation Zone Type in Specimens with Cone Length ≤ 10 mm versus > 10 mm—A Retrospective Analysis

The aim of this study was to evaluate the endocervical margin status according to transformation zone (TZ) and high-risk HPV (hr-HPV) subtype in specimens with cone length ≤ 10 mm versus > 10 mm to provide data for informed decision making and patients counseling especially for women wishing to conceive. In this retrospective cohort study, 854 patients who underwent large loop excision of the transformation zone during a nine-year period (2013–2021) for cervical disease were analyzed. The main outcome parameters were excision length, histological result, TZ type, HPV subtype and endocervical margin status. A subgroup analysis was performed according to excision length, with a cut-off value of 10 mm. A two-step surgical procedure was performed in case of an excision length of > 10 mm. The overall rate of positive endocervical margins irrespective of excision length was 17.2%, with 19.3% in specimens with ≤ 10 mm and 15.0% with > 10 mm excision length. Overall, 41.2% of women with a visible TZ and HPV 16/hr infection and 27.0% of women with HPV 18 received an excisional treatment of > 10 mm length without further oncological benefit, respectively. In contrast, assuming that only an excision of ≤ 10 mm length had been performed in women with visible TZ, the rate of clear endocervical margins would have been 63.7% for HPV 16/hr infections and 49.3% for HPV 18 infections. In conclusion, the decision about excision length should be discussed with the patient in terms of oncological safety and the risk of adverse pregnancy events. An excision length > 10 mm increases the number of cases with cervical tissue removed without further oncological benefit, which needs to be taken into account in order to provide an individual therapeutic approach. Furthermore, HPV 18 positivity is related to a higher rate of positive endocervical margins irrespective of TZ.
Phytochemicals targeting glycolysis in colorectal cancer therapy: effects and mechanisms of action

Colorectal cancer (CRC) is the third most common malignant tumor in the world, and it is prone to recurrence and metastasis during treatment. Aerobic glycolysis is one of the main characteristics of tumor cell metabolism in CRC. Tumor cells rely on glycolysis to rapidly consume glucose and to obtain more lactate and intermediate macromolecular products so as to maintain growth and proliferation. The regulation of the CRC glycolysis pathway is closely associated with several signal transduction pathways and transcription factors including phosphatidylinositol 3-kinases/protein kinase B/mammalian target of rapamycin (PI3K/AKT/mTOR), adenosine 5′-monophosphate (AMP)-activated protein kinase (AMPK), hypoxia-inducible factor-1 (HIF-1), myc, and p53. Targeting the glycolytic pathway has become one of the key research aspects in CRC therapy. Many phytochemicals were shown to exert anti-CRC activity by targeting the glycolytic pathway. Here, we review the effects and mechanisms of phytochemicals on CRC glycolytic pathways, providing a new method of drug development.
Development Expenditure Allocation and District Wise Social Development: A Case Study of Punjab Pakistan

In the wake of achieving Sustainable Development Goals, this study sets to investigate the allocation of development expenditures as government policy intervention and its role in the uplifting the social condition in districts of Punjab. The constriction of a comprehensive social development is indexed using principal factor analysis. This study considered panel data for 36 districts of Punjab ranging from 2008 to 2017. Estimates from the panel Random Effect model advocated that the rise in the development expenditures by the Government of Punjab follows U shape relationship with the social condition of the province. This quadratic model helps to estimate district-wise effects of government development intervention on social development and its components via which resource mobilization optimization can be done.
One Font Doesn’t Fit All: The Influence of Digital Text Personalization on Comprehension in Child and Adolescent Readers

Reading comprehension is an essential skill. It is unclear whether and to what degree typography and font personalization may impact reading comprehension in younger readers. With advancements in technology, it is now feasible to personalize digital reading formats in general technology tools, but this feature is not yet available for many educational tools. The current study aimed to investigate the effect of character width and inter-letter spacing on reading speed and comprehension. We enrolled 94 children (kindergarten–8th grade) and compared performance with six font variations on a word-level semantic decision task (Experiment 1) and a passage-level comprehension task (Experiment 2). Reading speed and comprehension were analyzed using generalized linear mixed-effects regression models. Independent samples t-tests compared speed and comprehension accuracy on personal best vs. worst font variation. A stability analysis was conducted to determine if participants had a stable personal best font variation within Experiment 1. The Experiment 1 stability analysis was statistically significant, and 58% of participants had a stable personal best font variation. Personal best font variations yielded significantly higher comprehension accuracy in both Experiments 1 and 2 and faster reading in Experiment 2. Using digital technology to personalize font may have important implications for school-aged readers.
Development and Validation of a Novel Risk Score for All-Cause Mortality Risk Stratification Prior to Permanent Pacemaker Implantation in Octogenarians or Older

Background and Objectives: The demand for permanent pacemaker (PPM) implantation for extremely old patients is increasing. Prior to implanting PPMs, life expectancy evaluation is essential but difficult. We aimed to develop and validate a scoring system for all-cause mortality risk stratification prior to PPM implantation in patients aged ≥80. Materials and Methods: A total of 210 patients aged ≥80 who received PPM implantation were included. Multivariable analysis was performed to assess the effects of different variables on all-cause mortality in a derivation cohort (n = 100). We developed the MELODY score for stratifying all-cause mortality prior to PPM implantation and tested the scoring system in a validation cohort (n = 102). Results: After 4.0 ± 2.7 years of follow-up, 54 patients (54%) had died. The 0.5-, 1- and 2-year all-cause mortality rates were 7%, 10% and 24%, respectively. The MELODY score based on body mass index <21 kg/m2 (HR: 2.21, 95% CI: 1.06–4.61), estimated glomerular filtration rate <30 mL/min/1.73 m2 (3.35, 1.77–6.35), length of hospitalization before PPM implantation >7 days (1.87, 1.02–3.43) and dyspnea as the major presenting symptom (1.90, 1.03–3.50) successfully distinguished patients at high risk of mortality. Patients with MELODY scores ≥3 had a higher risk of mortality compared to those with MELODY scores <3 (8.49, 4.24–17.00). The areas under the receiver operating characteristic curves in predicting 0.5, 1 and 2 years mortality rates were 0.86, 0.81 and 0.74, respectively. The predictive value of the model was confirmed in a validation cohort. Conclusions: The novel scoring system is a simple and effective tool for all-cause mortality risk stratification prior to PPM implantation in patients aged ≥80.
Natural Regeneration and Conservation Status of the Tree Community of Forest Remnants in Urban Parks in Southern Brazil

Purpose: The study characterised the dynamics of the natural regeneration process of urban remnants in four Curitiba (PR, Brazil) urban parks, aiming to contribute to the green infrastructure management process in Araucaria Forest areas. Theoretical framework: Urban forests offer significant socio-environmental benefits, being relevant for maintaining ecosystem services for cities and their inhabitants. Studying the regeneration of forest remnants in urban environments is essential for analysing their conservation status. Method/design/approach: The floristic diversity, structure, and population dynamics of the shrub-regenerating component of urban forest remnants were studied through the analysis of phytosociological parameters and the similarity between the shrub-regenerating, and arboreal components was verified. Results and conclusion: Significant dissimilarity was found between the study areas' regenerating shrub and tree components. The forest remnant of the Municipal Zoo, located in a locality with greater integration of different green areas, showed the best conservation status and a more advanced process of forest succession. Research implications: The analysis of the natural regeneration of urban remnants serves as an essential diagnosis regarding their conservation status and the capacity of species to perpetuate in the place, in addition to inferring about the connectivity with other urban remnants, being of great importance for the planning of actions aimed at the management of urban forests. Originality value: Analyzing natural regeneration generates information on forest remnants' conservation status and resilience, which is essential for planning actions for urban forest management.
Analysis of lcnRNA Homebox Transcript antisense RNA (HOTAIR) expression in Polish Women with Endometriosis

Long non-coding RNAs (lncRNAs) are implicated in endometriosis development. The aim of the study was to analyse the expression of lncRNA HOTAIR in the context of the risk of developing endometriosis.The presented study determined lncRNA HOTAIR expression in patients with endometriosis (n=100) compared with a healthy control group (n=100). Histological examination was performed by pathologists using a digital slide scanner and slide viewer software (Case Viewer 2.3, 3D Histech, Budapest, Hungary). The gene expression was measured by the reverse-transcription polymerase chain reaction (RT-PCR) technique. Two-step qRT-PCR was used to analyze the expression of HOTAIR gene in normal tissue and endometriosis samples. The total RNA was used for cDNA synthesis. Ct values were used for subsequent analysis and GADPH was used as the endogenous control.Statistically significantly higher HOTAIR expression was found in endometriosis samples compared to expression in the control material (p<0,0001). With regard to the classification of endometriosis (stage I-IV), there was a statistically significant increase HOTAIR expression in stage IV (p <0,05). There was no relationship between the age of the patients, the number of deliveries, the number of spontaneous abortions and BMI and the expression of HOTAIRThe reported studies suggest a significant role of lncRNA HOTAIR expression in the pathogenesis of endometriosis.
Lactational performance, rumen fermentation, nutrient use efficiency, enteric methane emissions, and manure greenhouse gas-emitting potential in dairy cows fed a blend of essential oils.

The objective of this experiment was to investigate the effects of an essential oil (EO) blend on lactational performance, rumen fermentation, nutrient utilization, blood variables, enteric methane emissions and manure greenhouse gas-emitting potential in dairy cows. A randomized complete block design experiment was conducted with 26 primiparous and 22 multiparous Holstein cows. A 2-wk covariate and a 2-wk adaptation periods preceded a 10-wk experimental period used for data and sample collection. Treatments were: (1) basal diet supplemented with placebo - CON; and (2) basal diet supplemented with a blend of EO containing eugenol and geranyl acetate as main compounds. Supplementation with EO did not affect dry matter intake, milk and energy-corrected milk yields, and feed efficiency of cows, compared with CON. Milk fat and lactose concentrations were increased, and milk TS concentration and milk fat yield tended to be increased by EO. Multiparous cows supplemented with EO tended to have slightly decreased dry matter and crude protein digestibility compared with CON multiparous cows. There was a tendency for increased ruminal pH by EO, whereas other rumen fermentation variables did not differ between treatments. Daily methane emission was not affected by EO supplementation, but methane emission intensity per kg of milk fat was decreased by 8.5% by EO. Methane emission intensity per kg of milk lactose and milk TS were decreased and methane emission intensity per kg of milk yield tended to be decreased by up to 10% in EO multiparous cows, but not in primiparous cows. The greenhouse gas-emitting potential of manure was not affected by EO supplementation. Compared with CON, fecal nitrogen excretion was increased by EO supplementation in multiparous, but not in primiparous cows, and milk nitrogen secretion (as a % of nitrogen intake) tended to be increased in EO supplemented cows. Blood variables were not affected by EO supplementation in the current study. Overall, dietary supplementation of EO did not affect lactational performance of the cows, although milk fat and lactose concentrations were increased. Most enteric methane emission metrics were not affected, but EO decreased methane intensity per kg of milk fat by 8.5%, compared with the control.
Digital Hardware Implementation of Morris-Lecar, Izhikevich, and Hodgkin-Huxley Neuron Models With High Accuracy and Low Resources

The neuron can be called the main cell of a nervous system that can transmit messages from one neuron to another neuron or another cell through electrical signals. In neuromorphic engineering, the hardware realization and simulation of these neurons are crucial. To accomplish a proper digital implementation (i.e. reducing hardware resources and increasing speed and accuracy) of three important neuron models including Hodgkin-Huxley, Morris-Lecar, and Izhikevich, this study proposes a set of multiplier-less mathematical equations based on converting nonlinear functions to $2^{x}$ functions. Then optimizes the proposed equations based on reducing the number of different $2^{x}$ terms. The suggested model can accurately recreate the behavioral characteristics of the original neuron models. The suggested model was synthesized and implemented on the Zynq XC7Z010 (3CLG400) reconfigurable board (FPGA) to validate the mathematical simulation findings. The results of hardware synthesizing and implementations of the proposed model show that different biological behavior can be replicated with greater efficiency and at substantially reduced implementation costs. This method (implemented on the zynq board) can raise the frequency of the proposed models at least by up to 3.5 times that of the original model and reduce power consumption between 20% and 60% for different proposed models. Also, due to the reduction of hardware resources in the proposed model, it is possible to implement a much larger number of neurons (between 4 and 12 times) relative to the original model on a single zynq board.
An Adaptive Management Approach for Summer Water Level Reductions on the Upper Mississippi River System

U.S. Geological Survey, Upper Midwest Environmental Sciences Center, 2630 Fanta Reed Road, La Crosse, Wisconsin 54603 Barko Environmental, PO Box 4949, Gulf Shores, Alabama 36547 E2 Consulting Engineers, 339 Whitecrest Drive, Maryville, Tennessee 37801 U.S. Fish and Wildlife Service, 1511 47th Avenue, Moline, Illinois 61265 Minnesota Department of Natural Resources, 1801 South Oak Street, Lake City, Minnesota 55041 U. S. Geological Survey, Missouri Cooperative Research Unit, 302 AnheuserBusch Natural Resources Building, University of Missouri, Columbia, Missouri 65211 U.S. Army Corps of Engineers, Engineering Research and Development Center, 3909 Halls Ferry Road, Vicksburg, Mississippi 39180 (Retired, current address: IIHR-Hydroscience and Engineering, University of Iowa, Iowa City, Iowa 52242)
Aerosol indirect effect in the thermal spectral range as seen from satellites

Insufficient knowledge about aerosol-cloud interactions has caused uncertainty in the Earth Radiation Budget. Lack of information about aerosol type, composition and concentration on global and regional scales also has restrained numerous efforts that have been made in the past to quantify the modulation of cloud properties by aerosols. Clouds, which cover more than half of the earth at any given time, have a key role in radiation budget. Most of the work has been done so far to understand modulation of cloud microphysical properties (in visible spectrum) by aerosols neglecting the thermal part. Satellites play unique role in improving knowledge about aerosol-cloud interactions through their ability to quantify spectral signatures of clouds and uniform, continuous sampling of the earth. Using long-term satellite data evaluations, this study reveals an entirely new aspect of these interactions and suggests that there exists indirect aerosol effect in the thermal spectrum. It suggests that anthropogenic aerosols, finer particles in particular, and cloud top temperature co-vary. This thermal effect could be equally important and hence cannot be neglected in radiation budget studies. First evidence of the impact of ship emissions on cloud properties over coastal waters is also presented.
Analysis The Quality Of Tourism Services And Facilities In Increasing The Happiness Of The Visiting Community (Study On Kayangan Hill Tourism, Renah Kayu Embun Village, Sungai Penuh City, Jambi Province)

Bukit Khayangan is the name of a flagship tour of Sungai Penuh City which is managed by the Department of Culture and Tourism of Sungai Penuh City. However, problems are still found because there are visitors who are disappointed because Bukit Khayangan Tourism is not well maintained, such as garbage scattered about because the trash can is not yet available. In addition, there are no guide officers who directly serve tourists. Tourist facilities such as tourist huts that were built on the strategic side of this tour are feared that the roof will fall on visitors who are sitting in the hut. Then the unavailability of lodging around the tour. This study uses a quantitative method with an associative approach whose aim is to determine the effect of the independent variable (Quality of Service and Tourism Facilities) on the dependent variable (Community Happiness). The population in this study were visitors to Bukit Khayangan Tourism in 2020, amounting to 15,512 people. The sample in the study was determined by the Taro Yamane formula and an error rate of 10%, so that a sample of 100 respondents was obtained. Then from the sample, using the Proportional Random Sampling technique, if the technique is not sufficient in the number of samples, it will be continued with the Accidental Sampling technique. by 26.6% ; tourism facilities on the happiness of the community from the R Square value of 0.103, which is 10.3%. And simultaneously, the two dependent variables on people's happiness from the Adjusted R Square value of 0.347, which is 34.7%. From the results of data processing, it is proven that the people who visit Bukit Khayangan Tourism are happy with the services provided by the tour manager and also the tourist facilities provided by the Sungai Penuh City Culture and Tourism Office.
Numerical modeling of uncertainty in acoustic propagation via generalized polynomial chaos

This work aims at increasing the performance prediction for acoustic propagation systems that will operate in the presence of the inevitable parameters uncertainty. In the present contribution, the finite element method is applied to solve an acoustic problem described by the Helmholz equation when the geometric and material properties present uncertainty. The influence of the uncertainty of physical parameters on the pressure field is discussed. The results using the polynomial chaos expansion method are compared with Monte Carlo simulations. It is show that uncertainty levels in the input data could result in large variability in the calculated pressure field in the domain.