Miracle-dz/UniFAR-FTUs huggingface dataset:
COMPARATIVE STUDY OF ANGIOTENSIN RECEPTOR BLOCKERS (ARBS) AND ANGIOTENSIN CONVERTING ENZYME INHIBITORS (ACEIS) FOR BP REDUCTION

The National WHO published guidelines in the management of hypertension beyond the approach of cardiovascular risk factors addressing the scheme of ACEI and ARB comparison to requisite the lifestyle modifications in the adherence of efficacy of safety goals. The ascertainment of mono-therapy and combined therapy trial reduced the systolic-diastolic BP statistically in the effectiveness of survival rates at the all-cause cardiac events. Moreover, the symptomatic optimal dosing randomized beneficially in the measurements of highest satisfactory intervention isolatedly arranged the sequence of ascending to descending structure directing the least potency on the pathogenesis of heart failure as the long-term hemodynamic vaso-dilators.
OTT_A_270090 13063..13075

1Department of Hematology, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, People’s Republic of China; 2Institute of Biotherapy for Hematological Malignancies, Shandong University, Jinan, Shandong, People’s Republic of China; 3Shandong University-Karolinska Institute Collaboration Laboratory for Stem Cell Research, Jinan, Shandong, People’s Republic of China; 4Clinical Laboratory, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, People’s Republic of China; 5Department of Hematology, Linyi Central Hospital, Linyi, Shandong, People’s Republic of China; 6Institute of Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, People’s Republic of China; 7Binzhou Medical University Hospital, Binzhou, Shandong, People’s Republic of China Background: We aimed to investigate the anti-multiple myeloma (MM) activity of the new small molecular compound AE-848 (5-bromo-2-hydroxyisophthalaldehyde bis[(1-methyl1H-benzimidazol-2-yl)hydrazone]) and its underlying anti-MM mechanism. Methods: Cell viability and apoptosis were detected and quantified by using MTT and flow cytometry, respectively. JC-1 dye-related techniques were used to assess mitochondrial membrane potential (MMP). Western blotting was applied to detect the expression of NFκB and PI3K/Akt/mTOR pathway-associated proteins. The in vivo activity of AE-848 against MM was evaluated in a MM mouse model. Results: Application of AE-848 into the in vitro cell culture system significantly reduced the viability and induced apoptosis of the MM cell lines, RPMI-8226 and U266, in a doseand time-dependent manner, respectively. JC-1 dye and Western blotting analysis revealed that AE-848 induced the cleavage of caspase-8, caspase-3, and poly ADP-ribose polymerase (PARP), resulting in loss of mitochondrial membrane potential (MMP). Both the NF-κB and PI3K/AKT/mTOR signaling pathways were involved in AE-848-induced apoptosis of U266 and RPMI8226 cells. Moreover, AE-848 leads to cell cycle arrest of MM cells. Its anti-MM efficacy was further confirmed in a xenograft model of MM. AE-848 administration significantly inhibited MM tumor progression and prolonged the survival of MM-bearing mice. More importantly, our results demonstrated that AE-848 markedly induced primary MM cell apoptosis. Conclusion: Our results for the first time showed that the small compound AE-848 had potent in vitro and in vivo anti-myeloma activity, indicating that AE-848 may have great potential to be developed as a drug for MM treatment.
Superficial Fungal Infections in ESRD Patients

Background: Patients with end stage renal disease commonly present a spectrum of dermatological disorders. Each one has its own unique presentation and treatment approaches. Superficial fungal infections of the skin do not account for much in the end stage renal disease patients; hence most of the reports do not discuss this issue. In the present study we analyzed patients with end stage renal disease who had developed superficial fungal infections. Methods: During January 2015 to June 2016, we tried to analyze 150 patients with end stage renal disease, who developed superficial fungal infections and were undergoing haemodialysis at least thrice a week for a minimum of three months at our centre. Results: Out of the 150 suspected cases we identified, 36 cultures tested positive. The macroscopic examination of the scalp, skin and the nails revealed 2.2% Tinea capitis, 13.9% Tinea versicolor, 44.5% Tinea corporis, 8.4% Tinea mannum, 16.8% onychomycosis, 5.7% Tinea cruris and 8.5% Tinea pedis. The culture examination highlighted 44.4% Trichyopyton rubrum , 27.8% Trychophyton mentagrophyte , 2.8% Trychophyton violaceum , 2.8% Trichophyton verrucosum , 2.8% Microsporum canis , 2.8% Epidermophyton flucossum , 2.8% Scopulariopsis brevicaulis and 13.8% Malessesia ). The predominant clinical abnormality observed was Tinea corporis and the prevalent fungal isolate was Trichophyton rubrum . Conclusion: current study management in these patients is taken. minimum of three months at our centre. Dermatological evaluation and confirmation of the presenting lesions were done by the dermatologist. In all cases, data related to the age, sex, duration of the lesions, occupation, personal habits etc was noted. After a detailed clinical examination, the physical features of the scalp, skin and nails were recorded. A lot of care was particularly taken to record the past history of superficial mycotic infections. Before obtaining a specimen, the infected areas were cleansed by swabbing them liberally with alcohol to eliminate as many bacteria as possible, because they can overgrow and inhibit the growth of dermatophytes. Scrapings and clippings were collected from the diseased portions of the scalp, skin and nails. When both the skin and the nails were affected, specimens were collected from both the sites. Each specimen was divided into two parts; one was taken for direct microscopic examination after 10% KOH solution treatment and the second was inoculated on sabouraud dextrose agar (M286) and sabouraud cycloheximide chloramphenicol agar (M664). Two successive cultures were performed to establish the colonization of the pathogen because successive sampling rarely demonstrates the same contaminant. Cultures were routinely incubated at 25–30°C and examined daily for up to 4 weeks. the cutaneous changes invasive fungal infections the
Men’s and towards dietary prevention of a prostate cancer diagnosis: a qualitative study.

Background: Prostate cancer (PC) incidence and progression may be influenced by dietary factors, but little is known about the acceptability of dietary modification to men at increased risk of PC. Qualitative interviews with men participating in the ProDiet study were undertaken to explore the feasibility of implementing dietary interventions for the prevention of prostate cancer. Methods: An interview study nested within the ProDiet randomised feasibility trial of dietary interventions to prevent a PC diagnosis. Men (n = 133) who previously participated in community based prostate specific antigen (PSA) testing without PC but who were at increased risk of the disease were randomly allocation to both lycopene (lycopene or placebo capsules or lycopene rich diet) and green tea (green tea or placebo capsules or green tea drink) for 6 months. Semi-structured interviews were conducted with participants shortly after randomisation, to investigate attitudes towards dietary modification for PC prevention and dietary information. Interviews were audio-recorded, transcribed and analysed to identify common themes. Results: Interviews were conducted with 21 participants aged 52-72 years with PSA levels between 2.5 and 2.95 ng/ml, or a negative prostate biopsy result. Most men identified the major causes of cancer in general to include diet, environment, ageing and genetic factors. This contrasted sharply with men ’ s uncertainty about PC aetiology, and the function of the prostate. Men were confused by conflicting messages in the media about dietary practices to promote health overall, but were positive about the potential of lycopene and green tea in relation to PC prevention, valuing their natural components. Furthermore these men wanted tailored dietary advice for PC prevention from their clinicians, whom they considered a trusted source of information. Conclusion: Men at elevated risk of PC reported uncertainty about PC aetiology and the role of diet in PC prevention, but enthusiasm for dietary modifications that were perceived as ‘ simple ’ and ‘ natural ’ . The men looked to clinicians to provide consistent disease specific dietary advice. These factors should be taken into consideration by clinicians discussing elevated PSA results with patients and those planning to embark on future trials investigating dietary modification interventions for the prevention of a PC diagnosis.
original Stem trait spectra underpin multiple functions of temperate gymnosperm and angiosperm tree 3

This study evaluated stem strategy spectra using a comprehensive set of anatomical, chemical and morphological traits addressing the key functions of stem compartments (innerwood, 20 outerwood and bark). Abstract 24 A central paradigm in comparative ecology is that species sort out along a global economic 25 strategy spectrum, ranging from slow to fast growth. Many studies evaluated plant strategy 26 spectra for leaf traits, but few studies evaluated stem strategy spectra using a comprehensive 27 set of anatomical, chemical and morphological traits, addressing key stem functions of 28 different stem compartments (inner wood, outer wood and bark). This study evaluates how 29 stem traits vary in the wood and bark of temperate tree species, and whether a slow-fast 30 growth strategy spectrum exists and what traits make up this plant strategy spectrum. For 14 31 temperate gymnosperm and angiosperm species, 20 traits belonging to six key stem functions 32 were measured for three stem compartments. 33 Both across and within gymnosperms and angiosperms, a slow-fast stem strategy 34 spectrum is found. Gymnosperms have slow traits and showed converging stem strategies 35 because of their uniform tracheids. Angiosperms have fast traits and showed diverging stem 36 strategies because of a wider array of tissues (vessels, parenchyma and fibers) and vessel size 37 and arrangements (ring-porous versus diffuse porous). Gymnosperms showed a main 38 trade-off between hydraulic efficiency and safety, and angiosperms showed a main trade-off 39 between ‘slow’ diffuse porous species and ‘fast’ ring porous species. The slow traits of 40 gymnosperms allow for a high hydraulic safety, an evergreen leaf habit and steady but slow 41 growth makes them successful in unproductive habitats whereas the fast traits of angiosperms 42 allow for high conductivity, a deciduous leaf habit and fast growth which makes them 43 successful in productive habitats.
Olaratumab exerts anti-tumor activity in preclinical models of pediatric bone and soft 1 tissue tumors through inhibition of platelet-derived growth factor receptor α in

intensive, multimodal therapeutic regimens debilitating long side effects. in these pediatric malignancies. study, we demonstrate the anti-tumor activity of olaratumab in combination with standard chemotherapy in preclinical models of pediatric bone and soft tissue tumors. These data of olaratumab in combination with chemotherapy in pediatric patients Abstract Purpose: Platelet-derived growth factor receptor alpha (PDGFRα) is implicated in several adult 49 and pediatric malignancies, where activated signaling in tumor cells and/or cells within the 50 microenvironment drive tumorigenesis and disease progression. Olaratumab (LY3012207/IMC- 51 3G3) is a human monoclonal antibody that exclusively binds to PDGFRα and recently received 52 accelerated FDA approval and conditional EMA approval for treatment of advanced adult 53 sarcoma patients in combination with doxorubicin. In this study, we investigated olaratumab in 54 preclinical models of pediatric bone and soft tissue tumors. 55 Experimental Design: PDGFRα expression was evaluated by qPCR and western blot analysis. 56 Olaratumab was investigated in in vitro cell proliferation and invasion assays using pediatric 57 osteosarcoma and rhabdoid tumor cell lines. In vivo activity of olaratumab was assessed in 58 preclinical mouse models of pediatric osteosarcoma and malignant rhabdoid tumor. 59 Results: In vitro olaratumab treatment of osteosarcoma and rhabdoid tumor cell lines reduced 60 proliferation and inhibited invasion driven by individual PDGFs or serum. Furthermore, 61 olaratumab delayed primary tumor growth in mouse models of pediatric osteosarcoma and 62 malignant rhabdoid tumor and this activity was enhanced by combination with either doxorubicin 63 or cisplatin. Conclusion: Overall, these data indicate that olaratumab, alone and in combination with 65 standard of care, blocks the growth of some preclinical PDGFRα-expressing pediatric bone and 66 soft tissue tumor models.
Effect of aging on lignin content, composition and enzymatic sacchari ﬁ cation in Corymbia hybrids and parental taxa between years 9 and 12 Biomass and Bioenergy

Corymbia (a eucalypt) is an important forestry genus and a potential lignocellulosic bioenergy feedstock. The composition of the lignocellulosic cell wall signi ﬁ cantly impacts pretreatment ef ﬁ ciency and conversion to biofuel but is variable and changes with age. In this study, we estimated Klason lignin content, composition, and monosaccharide (glucose and xylose) release after enzymatic sacchari ﬁ cation of untreated and hydrothermally pretreated biomass from Corymbia parental species Corymbia torelliana (CT), Corymbia citriodora subsp. variegata (spotted gum; CCV), and interspeci ﬁ c F1 hybrids (CT (cid:1) CCV) at ages 9 and 12 years from planting. Analysis of lignin composition derived from syringyl/guaiacyl monolignols (S/G) found signi ﬁ cant differences among taxa, with CT S/G ratios (2.2 and 2.0) being signi ﬁ cantly lower than CCV (2.6 and 2.3) or hybrids (2.5 and 2.3) at ages 9 and 12 respectively. In general, enzymatic sacchari ﬁ cation yields from untreated biomass were signi ﬁ cantly different among taxa, with CT (113 and 75 mg g (cid:3) 1 ) and hybrids (108 and 81 mg g (cid:3) 1 ) yielding signi ﬁ cantly higher glucose from untreated biomass than CCV (82 and 56 mg g (cid:3) 1 ) at ages 9 and 12 respectively. Comparison of traits within taxa between ages 9 and 12 found S/G ratios and glucose yields from untreated biomass were signi ﬁ cantly lower in CT, CCV and hybrid taxa. In conclusion, the formation of lignocellulosic cell walls is complex, in ﬂ uenced by genetics and age of material, requiring optimization of rotation age for biofuel production and other industrial processes.
THE RAW DOG FOOD – ADVANTAGES AND DISADVANTAGES

In recent years, raw foods have become increasingly popular in the world, for the dog's owners. Contra-dictory data on this type of diet have been reported in the literature. Some authors note that the use of raw foods has a beneficial effect on the health of the dog, while others point to the food safety and health risks of both the dog and the owner. The purpose of the current survey is to analyze current data on the advantages and disadvantages of raw foods, known as “Bones and Raw Food” or “Biologically Appropriate Raw Food” (BARF)/„Raw meat-based diets” (RMBDs).
Neutrophil-to-lymphocyte ratio exhibits the different correlation with psychiatric symptoms in the different status of antipsychotic therapy in schizophrenia: a large-scale retrospective cross-sectional study. CURRENT STATUS: POSTED

Background There are some conflicting results regarding the neutrophil-to-lymphocyte ratio (NLR) and the severity of disease in patients with schizophrenia. Inconsistent findings among the studies might be caused by several limitations, such as, heterogeneous patient populations lacking stratification by antipsychotic therapy, small sample sizes lacking statistical power, ignoring multicollinearity between NLR and other related factors, and lack of controlling for potential confounding factors. In this study, we evaluated the possible correlation between NLR and disease severity as manifested in clinical scores in patients with schizophrenia. In particular, NLR is correlated with discrepant psychiatric symptoms in the different status of antipsychotic medication administration. Methods This was a cross-sectional study conducted in our hospital. We identified inpatients with schizophrenia between July 12, 2018 and March 27, 2019 and who had NLR, Clinical Global Impression Severity scale (CGIS) and Brief Psychiatric Rating Scale (BPRS) scores. Results The records of 1144 identified patients (32.4% male, 76.6% with NLR ≤ 1.98, and 10.8% drug-free patients) were analyzed. Multivariate logistic regression showed that NLR was positively associated with worse psychiatric symptoms, both the CGIS score (moderately ill: OR: 63.578, p = 0.011; severely ill: OR: 53.617, p = 0.015) and the BPRS total score (moderately ill: OR: 4.049, p = 0.055; severely ill: OR: 4.312, p = 0.045). In the drug-therapy subgroup, there was a negative correlation between NLR and severe negative symptoms (severely ill: OR: 0.850, p = 0.018) after controlling for potential confounding factors. Conclusions The study is the first to confirm the hypothesis that NLR is independently associated with severe psychopathology in schizophrenia. There is the different correlation between NLR and psychiatric symptoms in the different status of antipsychotic therapy. Therefore, NLR is not appropriate to be an inflammatory biomarker for assessment of disease severity, but provide potential mechanistic insights on specific pathological cellular processes, as well be a potential target to improve the course of interaction conflicting results about evaluation of the possible correlation of NLR and disease severity between previous literatures and our present study, because of heterogeneous patient populations and methodological discrepancies, additionally small sample sizes. First, our findings presented that decreased NLR in the drug-therapy patients when compared to the drug-free patients. Further, it was observed that there was a negative relation between NLR and antipsychotic medication in total patients either with Spearman correlation analysis or with logistic regression analysis. It is indicated there was a significant effect of antipsychotics on NLR in patients patient patients into drug-free and drug-therapy.
Institutional Knowledge at Singapore Management University VAT Treatment of Financial Institutions

Abtract: This paper studies the eﬀects of exempt treatment of ﬁnancial services under a VAT system. We develop a general equilibrium model with elastic labor supply, endogenous entry, and a banking sector. The banking sector provides loan services to producers and payment services to consumers. Our model display three key distortions under exempt treatment: (i) self-supply bias in the banking sector, (ii) consumption distortions, (iii) input distortions and tax cascading. Then, we calibrate our model to match the salient features of the tax system EU countries. A tax neutral policy regime switch from exempt treatment to full-taxation in loan services improves welfare about 4%. Shutting down the entry margin has even bigger welfare gains. The same policy exercise for payment services also implies welfare gains and these gains greater than zero rating of payment services.
CIPK23 regulates HAK5-mediated high-affinity K + uptake in 1 Arabidopsis roots 2

Plant growth and development requires efficient acquisition of essential 26 elements. Potassium (K + ) is an important macronutrient present in the soil 27 solution at a wide range of concentrations. Regulation of the K + uptake systems 28 in the roots is essential to secure K + supply. It has been shown in Arabidopsis 29 that when the external K + concentration is very low (<10 µM), K + nutrition 30 depends exclusively on the high-affinity K + transporter HAK5. Low-K + induced 31 transcriptional activation of the gene encoding HAK5 has been previously 32 reported. Here we show the posttranscriptional regulation of HAK5 transport 33 activity by phosphorylation. Expression in a heterologous system showed that 34 the Ca 2+ sensors CBL1, CBL8, CBL9 and CBL10, together with CBL-interacting 35 kinase CIPK23 activated HAK5 in vivo . This activation produced an increase in 36 the affinity and the V max of K + transport. In vitro experiments show that the N- 37 terminus of HAK5 is phosphorylated by CIPK23. This supports the idea that 38 phosphorylation of HAK5 induces a conformational change that increases its 39 affinity for K + . Experiments of K + (Rb + ) uptake and growth measurements in low- 40 K + medium with Arabidopsis single mutants hak5 , akt1 and cipk23 , double 41 mutants hak5 akt1 , hak5 cipk23 , akt1 cipk23, and the triple mutant hak5 akt1 42 cipk23 confirmed the regulatory role of CIPK23 in planta . 43
Wild ramification and the cotangent bundle

We define the characteristic cycle of a locally constant \'etale sheaf on a smooth variety in positive characteristic ramified along boundary as a cycle in the cotangent bundle of the variety, at least on a neighborhood of the generic point of the divisor on the boundary. The crucial ingredient in the definition is an additive structure on the boundary induced by the groupoid structure of multiple self products. We prove a compatibility with pull-back and local acyclicity in non-characteristic situations. We also give a relation with the characteristic cohomology class under a certain condition and a concrete example where the intersection with the 0-section computes the Euler-Poincar\'e characteristic.
NDT_A_325000 2637..2646

Department of Psychiatry, Faculty of Medicine, Medical University of Gdańsk, Gdańsk, Poland Purpose: Bipolar disorder is a chronic and recurrent condition often associated with treatment resistance and suicidality. There is an unmet need for effective treatment in this group of patients. Ketamine has been demonstrated to have antidepressant and antisuicidal properties in unipolar depression. Most of the available studies concern unipolar depression. Here, we present the efficacy and safety of IV ketamine as an add-on treatment in patients with bipolar I and bipolar II depression. Patients and Methods: Thirteen patients with treatment-resistant bipolar depression (TRBD) received eight IV infusions of 0.5 mg/kg ketamine twice a week over four weeks. This is an open-label naturalistic observational study. Ketamine is an add-on treatment. Depressive symptoms were measured with the Montgomery–Asberg Depression Rating Scale (MADRS), and manic symptoms were measured with the Young Mania Rating Scale (YMRS). Psychomimetic symptoms were assessed with the Clinician-Administered Dissociative States Scale (CADSS) and the Brief Psychiatric Rating Scale (BPRS). Results: The rates of response and remission after the seventh infusion of ketamine were 61.5% and 46.2%, respectively. A significant antisuicidal effect was observed in responders at the 7th infusion. Suicidality was measured with item 10 on the MADRS scale. The average time to respond was between 21.1 and 23.2 days to remission. There was an increase in the CADSS scores during the treatment compared to baseline and follow-up, but no differences between responders and non-responders were observed. No affective switch was observed according to the YMRS scale scores. Ketamine treatment was associated with a transient increase in arterial blood pressure. No serious adverse events, however, were observed. Conclusion: This report presents the preliminary results of IV ketamine effectiveness and safety in treatment-resistant bipolar depression. The findings suggest that it is a feasible, safe and well-tolerated treatment option in this group of patients. There is a definite need for more studies in this field.