Miracle-dz/UniFAR-FTUs huggingface dataset:
A comparison of burnout among oncology nurses working in adult and pediatric inpatient and outpatient settings.

PURPOSE/OBJECTIVES To investigate differences in burnout among oncology nurses by type of work setting, coping strategies, and job satisfaction. DESIGN Descriptive. SETTING A metropolitan cancer center. SAMPLE A convenience sample of 74 oncology nurses. METHODS Participants completed a demographic data form, the Nursing Satisfaction and Retention Survey, and the Maslach Burnout Inventory. MAIN RESEARCH VARIABLES Burnout, coping strategies, job satisfaction, and oncology work setting (inpatient versus outpatient and adult versus pediatric). FINDINGS The participants most often used spirituality and coworker support to cope. Emotional exhaustion was lowest for youngest nurses and highest for outpatient RNs. Personal accomplishment was highest in adult settings. Job satisfaction correlated inversely with emotional exhaustion and the desire to leave oncology nursing. CONCLUSIONS The findings support that the social context within the work environment may impact emotional exhaustion and depersonalization, and that demographics may be more significant in determining burnout than setting. IMPLICATIONS FOR NURSING The findings raise questions of whether demographics or setting plays a bigger role in burnout and supports organizational strategies that enhance coworker camaraderie, encourage nurses to discuss high-stress situations, and share ways to manage their emotions in oncology settings. KNOWLEDGE TRANSLATION Spirituality and coworker relationships were positive coping strategies among oncology nurses to prevent emotional exhaustion. Nurses who rely on supportive social networks as a coping mechanism have lower levels of depersonalization. Age was inversely related to emotional exhaustion.
Competitive Endogenous RNA (ceRNA) Regulation Network of lncRNA-miRNA-mRNA in Wilms tumor CURRENT STATUS:

Background: Competitive endogenous RNA (ceRNA) have revealed a new mechanism of interaction between RNAs. However, such comprehension of the ceRNA regulatory network in Wilms tumor remains limited.Methods: The expression profiles regarding mRNAs, miRNAs and lncRNAs on Wilms tumor samples and normal samples were obtained from Therapeutically Applicable Research to Generate Effective Treatment (TARGET) database. EdgeR package was applied to identify differentially expressed lncRNAs, miRNAs and mRNAs. Functional enrichment analyses via the ClusterProfile R package was done. following which the lncRNA–miRNA–mRNA interaction ceRNA network was established in Cytoscape . Subsequently, correlation between ceRNA network and overall survival prognosis were analyzed. Results: A total of 2,037 lncRNAs, 154 miRNAs and 3,609 mRNAs were identified as differentially expressed RNAs in Wilms tumor. 205 lncRNAs, 26 miRNAs and 143 mRNAs were included in ceRNA regulatory network. The result of Gene Ontology analysis revealed that DEGs were enriched mainly in response to mechanical stimulus, transcription factor complex, and transcription factor activity (RNA polymerase II proximal promoter sequence-specific DNA binding). The result of the Kyoto Encyclopedia of Genes and Genomes pathway analysis showed that DEGs were enriched mainly in cell cycle. Survival analysis results showed that 14 out of the 205 lncRNAs, 1 out of 26 miRNAs and 8 out of 143 mRNAs were associated with overall survival in Wilms tumor patients (P < 0.05). Conclusions: CeRNA networks played an important role in Wilms tumor. This might provide effective novel insights for further understanding of the mechanisms underlying Wilms tumor.
The Montreal Cognitive Assessment (MoCA) in a population-based sample of Turkish migrants living in Germany

ABSTRACT Objectives: Data on cognitive testing in migrants in Germany are scarce. We aimed to evaluate the Montreal Cognitive Assessment (MoCA) in Turkish migrants in Berlin and its association with demographics and health-related variables. Method: For this cross-sectional study, a random sample of persons with Turkish names was drawn from the registration-office. Cognitive function was assessed using the MoCA; 0 = worst, 30 = best total score. Multivariable linear regression models were calculated to determine associated factors with the total MoCA-score. Results: In our analyses we included 282 participants (50% female), mean age 42.3 ± 11.9 years (mean ± standard deviation (SD)). The mean ± SD MoCA score was 23.3 ± 4.3. In the multivariable analysis, higher education (ß = 2.68; p < 0.001), and chosing the German version of the MoCA (ß = –1.13; p = 0.026), were associated with higher MoCA-scores, whereas higher age (ß = –0.08; p = 0.002) was associated with lower MoCA scores. Conclusion: In our study, a higher educational level, lower age, and German as the preferred test language (as compared to Turkish) were positively associated with the cognitive performance of Berliners with Turkish roots. To examine neurocognitive health of migrants, longitudinal population-based and clinical cohort studies that specifically compare migrants and their descendants with the original population of their home countries are required.
Correlated k-distribution method for radiative transfer in climate models: Application to effect of cirrus clouds on climate

A radiative transfer method appropriate for use in simple climate models and three dimensional global climate models was developed. It is fully interactive with climate changes, such as in the temperature-pressure profile, cloud distribution, and atmospheric composition, and it is accurate throughout the troposphere and stratosphere. The vertical inhomogeneity of the atmosphere is accounted for by assuming a correlation of gaseous k-distributions of different pressures and temperatures. Line-by-line calculations are made to demonstrate that The method is remarkably accurate. The method is then used in a one-dimensional radiative-convective climate model to study the effect of cirrus clouds on surface temperature. It is shown that an increase in cirrus cloud cover can cause a significant warming of the troposphere and the Earth's surface, by the mechanism of an enhanced green-house effect. The dependence of this phenomenon on cloud optical thickness, altitude, and latitude is investigated.
"Ancient pigs reveal a near-complete genomic turnover following their introduction to Europe (vol 116, pg17231, 2019)

Near associated with European wild boars. turnover be for by substantial gene flow from local wild boars, it is also possible that European wild boars were domesticated independently without any genetic contribution from the Near East. To test these hypotheses, we obtained mtDNA sequences from 2,099 modern and ancient pig samples and 63 nuclear ancient genomes from Near Eastern and European pigs. Our analyses revealed that European domestic pigs dating from to 6,000 y BP possessed both Near Eastern and European nuclear ancestry, while later pigs possessed no more than 4% Near Eastern ancestry, indicating that gene flow from European wild boars resulted in a near-complete disappearance of Near East ancestry. In addition, we demonstrate that a variant at a locus encoding black coat color likely originated in the Near East and persisted in European pigs. Altogether, our results indicate that while pigs were not independently domesticated in Europe, the vast majority of human-mediated selection over the past 5,000 y focused on the genomic fraction derived from the European wild boars, and not on the fraction that was selected by early Neolithic farmers over the first 2,500 y of the domestication process.
Ancient pigs reveal a near-complete genomic turnover following their introduction to Europe

Frantz, L. A. F. , Haile, J., Lin, A. T. , Scheu, A. , Geörg, C. , Benecke, N. , Alexander, M. , Linderholm, A. , Mullin, V. E. , Daly, K. G. , Battista, V. M. , Price, M. , Gron, K. J., Alexandri, P., Arbogast, R. M. , Arbuckle, B. , Bǎlǎşescu, A. , Barnett, R. , Bartosiewicz, L. , . Larson, G. (2019). Ancient pigs reveal a near-complete genomic turnover following their introduction to Europe. Proceedings of the National Academy of Sciences of the United States of America, 116(35), 17231-17238. https://doi.org/10.1073/pnas.1901169116
An Automatic Method for Subglacial Lake Detection in Ice Sheet Radar Sounder Data

During the past decades, radar sounder (RS) instruments have been effectively used to detect subglacial lakes (SLs). SLs appear as flat, smooth, and bright reflectors in RS radargrams. The visual interpretation has been the main approach to SL detection in radargrams. However, this approach is subjective and inappropriate for processing large amounts of radargrams. While the analysis of RS data for understanding the subglacial hydrology has recently received increased attention, the literature on the development of automatic methods specifically designed for SL detection is still limited. In order to fill this gap, in this paper, we propose a novel automatic technique for SL detection. The technique is made up of two steps: 1) feature extraction and 2) automatic detection. In the first step, we define and extract three families of features for discriminating between the lake and nonlake radar reflections. The features model locally the basal topography, the shape of the basal reflected waveforms, and the statistical properties of the basal signal. In the second step, we provide the features as input to a support vector machine classifier to perform the automatic SL detection. The proposed technique has been applied to radargrams acquired over two large regions in East Antarctica and Siple Coast. The obtained results, which are validated both quantitatively and qualitatively, confirm the robustness of the features and their capabilities to effectively characterize SLs. Moreover, they prove the potentiality of the method to process large amounts of radargrams and update the current SL inventory.
The Association Between Balance , Fear of Falling and Daily Activities in Drug Phases and Different Levels of Disease Severity in Patients with Parkinson ' s Disease

Purpose: In the elderly, functional balance, fear of falling and independence in activities of daily living are interrelated; however, this association may change under the influence of drug phase and the severity of disease in individuals with idiopathic Parkinson's disease. The aim of this study was to investigate the relationship between functional balance, fear of falling and independence in activities of daily living in drug onand off-phase. Method: One hundred forty patients with Parkinson's Disease (mean age ± SD; 60.51± 12.32 years) were evaluated in terms of functional balance, fear of falling and independence in activities of daily living using the Berg Balance Scale, Fall Efficacy Scale-International, and Unified Parkinson Disease Rating Scale–activities of daily living, respectively, in drug onand off -phases. Global disease rating was recorded by Hoehn and Yahr scale. Spearman coefficient, Kruskal-Wallis and Mann-Whitney tests were used to find out if the distribution of scale scores differs among levels of functional balance or among levels of disease severity. Results: A strong correlation was found between the functional balance, fear of falling and independence in activities of daily living in both drug phases. The results also showed the significant difference in distribution of the Fall Efficacy Scale-International and Unified Parkinson Disease Rating Scale–activities of daily living scores among levels of functional balance (except independence in activities of daily living in drug off-phase). Also the distribution of the scores of Berg Balance Scale, Fall Efficacy Scale-International and Unified Parkinson Disease Rating Scale-activities of daily living showed significant differences among levels of disease severity.
A clinical study: management of distal tibial fractures with minimally invasive plating osteosynthesis

<p class="abstract"><strong>Background:</strong> Distal tibial fractures of bone poses major challenge to the trauma orthopaedic surgeons as this bone is subcutaneous associated with soft tissue injuries and precarious blood supply. Distal tibial fractures require accurate reduction, perfect articular restoration with stable fixation with minimal stripping of soft tissues, thereby preserving the blood supply. Minimally invasive osteosynthesis using locking plates has emerged as viable option of fixing such fractures due to poor results associated with open plating which leads to extensive soft tissues stripping and subsequently poor blood supply. </p><p class="abstract"><strong>Methods:</strong> 27 patients with closed distal tibial fractures with or without articular involvement without vascular compromise were treated with LCP fixation using MIPO technique studied from June 2017 to December 2018. <strong></strong></p><p class="abstract"><strong>Results:</strong> All fractures in our series united well at the end of 5 months with mean time to clinical and radiological union was 17 weeks. There was no case of implant failure while 2 patients had varus angulation. Very few soft tissue complications with excellent functional outcome were seen. </p><p><strong>Conclusions:</strong> We concluded that distal tibial fractures can be effectively managed with LCP using MIPPO technique with excellent functional outcome and avoiding the complications associated with other treatment methods. </p>
Relação entre equilíbrio dinâmico e qualidade de vida de participantes de um programa de atividade física voltado ao público idoso

Introduction: Postural balance is one of the most important factors associated to falls. Physical activity has been a tool to improve this balance. Objective: To investigate the association between dynamic balance and quality of life in participants of an extension project focused on physical activity for older adults. Methods: A cross-sectional and ex post facto study was conducted. The sample consisted of 94 subjects. We used a sociodemographic questionnaire, test stand, walk 2.44 m and back to sit in a chair and the SF-36. Results: There were significant correlations between the dynamic balance and all domains of the SF-36, included general sum of quality of life. This result indicates that higher scores in quality of life, better is the results of balance. Conclusion: Thus, we have to focus on working on body balance in order to improve quality of life of the elderly and their awareness of autonomy and independence in daily tasks.
nab-paclitaxel in pretreated metastatic breast cancer: evaluation of activity, safety, and quality of life

Objective: Metastatic breast cancer (MBC) is an incurable disease; the treatment of this disease prolongs survival, improving the quality of life (QoL) with a balance between efficacy and toxicity of the treatment. In recent years, treatment with nab-paclitaxel has improved the already known antitumor activity of conventional paclitaxel, in terms of increased efficacy and better tolerability. The aim of this study was to evaluate nab-paclitaxel in Italian patients with MBC. Methods: We conducted a retrospective analysis of 90 patients with histologically confirmed diagnosis of MBC. To evaluate the efficacy of nab-paclitaxel, overall survival (OS), progression-free survival (PFS), and overall response rate were the primary endpoints, whereas carbohydrate antigen 15.3 (Ca15.3) reduction, QoL, and tolerability were second-ary endpoints. Results: The median OS was 10.4 months, the median PFS was 6.8 months. A considerable difference Ca15.3 before and after treatment was observed. Descriptive and regression analyses were done to examine the associations between Ca15.3 response and OS, demonstrating good correlation, revealing that Ca15.3 reduction is an important predictor of OS. Conclusion: Nab-paclitaxel is an effective and well-tolerated treatment of patients affected by MBC. The drug showed an improved tolerability profile. With all the limitations of the obser-vational nature of our results, nab-paclitaxel has proven to be an effective and safe therapeutic option in patients with MBC.
GENETIC AND ENVIRONMENTAL PREDICTORS OF EMPATHY IN CHILDREN AT RISK FOR AN AUTISM SPECTRUM DISORDER By

of a dissertation at the University of Miami. Dissertation supervised by Dr. Daniel Messinger. No. of pages in text (58) Individuals with autism spectrum disorders (ASD) have difficulty empathizing with others. These empathy deficits are apparent from as early as 12 months of age and predict later ASD diagnosis and symptom severity; however, the factors that influence empathy development in children at risk for an ASD are not clear. In typically developing samples, genetic factors, such as the oxytocin receptor gene (OXTR), and environmental factors, such as early parent-child interactions, contribute to individual differences in empathy. In this study, I investigated the influence of OXTR variants and characteristics of early parent-child interactions on later empathic behavior in toddlers at high-and low-risk for an ASD. Additionally, the influence of OXTR on ASD symptom severity was explored within the high-risk group. ASD risk status was defined by the presence or absence of an older sibling with an ASD. Parent-child interaction was measured during free play sessions at 15 and 18 months of age. Empathy was measured through the children's responses to their parent's simulated distress at 24 and 30 months. ASD symptom severity was measured with the Autism Diagnostic Observation Schedule. A dyadic parent-child interaction variable, affective mutuality, predicted later empathic behavior. By contrast, a parenting composite variable, emotional supportiveness, did not predict later child empathy. There were no significant main effects for either OXTR marker (rs53576 or rs2254298); however, the genotype for one of the markers (rs53576) moderated the relation between affective mutuality and later empathic behavior. There was no direct relation between OXTR and ASD symptom severity. This is the first study to investigate predictors of empathy in a sample including children at heightened risk for an ASD. Findings suggest that genetics factors, such as OXTR, and early parent-child interactions interact to influence individual differences in empathy in children at both high-and low-risk for an ASD. Individuals with autism spectrum disorders (ASD) demonstrate difficulty empathizing with others (i.e., identifying with others' emotional experiences). These empathy deficits are apparent from as early as 12 months of age and predict later ASD diagnosis and symptom severity (Hutman et al., 2010; McDonald & Messinger, in press). While there is evidence to suggest that empathy development is influenced by specific genetic and environmental factors in typically developing children, the factors that influence the development of this essential ability in young children at risk for …
Poskus opredelitve sodobnih problemov razvoja kulturne pokrajine slovenskega podeželja

This treatise attempts to de. ne contemporary problems in the development of the cultural landscape in the Slovenian countryside. These problems have been caused by different developments during three phases of socio-economic land use in Slovenia. Among the problems discussed are how to make good a de. ciency of land structure, how to deal with limited natural resources for modern farming, and how to hinder deepening of regional differentiation in the economic development of Slovenia, which is connected also with the decay ofthe cultural landscape in farming areas in the periphery.
Towards population genomics in non-model species with large genomes: a case study of the marine zooplankton Calanus finmarchicus

Advances in next-generation sequencing technologies and the development of genome-reduced representation protocols have opened the way to genome-wide population studies in non-model species. However, species with large genomes remain challenging, hampering the development of genomic resources for a number of taxa including marine arthropods. Here, we developed a genome-reduced representation method for the ecologically important marine copepod Calanus finmarchicus (haploid genome size of 6.34 Gbp). We optimized a capture enrichment-based protocol based on 2656 single-copy genes, yielding a total of 154 087 high-quality SNPs in C. finmarchicus including 62 372 in common among the three locations tested. The set of capture probes was also successfully applied to the congeneric C. glacialis. Preliminary analyses of these markers revealed similar levels of genetic diversity between the two Calanus species, while populations of C. glacialis showed stronger genetic structure compared to C. finmarchicus. Using this powerful set of markers, we did not detect any evidence of hybridization between C. finmarchicus and C. glacialis. Finally, we propose a shortened version of our protocol, offering a promising solution for population genomics studies in non-model species with large genomes.
TIN2 functions with TPP1/POT1 to stimulate telomerase processivity

Telomere length maintenance is crucial for cells that divide many times. TIN2 is an important regulator of telomere length, and mutations in TINF2, the gene encoding TIN2, cause short telomere syndromes. While the genetics underscore the importance of TIN2, the mechanism through which TIN2 regulates telomere length remains unclear. Here, we characterize the effects of TIN2 on telomerase activity. We identified a new isoform in human cells, TIN2M, that is expressed at similar levels to previously studied TIN2 isoforms. Additionally, we found that all three TIN2 isoforms stimulated telomerase processivity beyond the previously characterized stimulation by TPP1/POT1. Mutations in the TPP1 TEL-patch abrogated this stimulation, implicating TIN2 as a component of the TPP1/POT1 processivity complex. All three TIN2 isoforms localized to telomeres in vivo but had distinct effects on telomere length, suggesting they are functionally distinct. These data contrast previous descriptions of TIN2 a simple scaffolding protein, showing that TIN2 isoforms directly regulate telomerase.
Pengaruh dana pihak ketiga, kecukupan modal dan penyaluran kredit terhadap profitabilitas bank

This study aims to provide empirical evidence about the effect of DPK (Third Party Funds), CAR (Capital Adequacy Ratio), LDR (Loan to Deposit Ratio), and BOPO (Operating Expenses to Operating Income) on the profitability (ROA) of state banks. The multiple linear regression with classic assumption test was used to hypothesis testing. The results showed that DPK, LDR, and BOPO had a positive and significant effect on ROA, while CAR has no significantly effect. Among all the independent variables studied, DPK is the dominant variable affecting ROA, and, ROA can explained by the variables studied at 81.4% while the remainder was explained by other factors not included in the study.