Miracle-dz/UniFAR-FTUs huggingface dataset:
Epigenetic Dysregulations in Merkel Cell Polyomavirus-Driven Merkel Cell Carcinoma

Merkel cell polyomavirus (MCPyV) is a small DNA virus with oncogenic potential. MCPyV is the causative agent of Merkel Cell Carcinoma (MCC), a rare but aggressive tumor of the skin. The role of epigenetic mechanisms, such as histone posttranslational modifications (HPTMs), DNA methylation, and microRNA (miRNA) regulation on MCPyV-driven MCC has recently been highlighted. In this review, we aim to describe and discuss the latest insights into HPTMs, DNA methylation, and miRNA regulation, as well as their regulative factors in the context of MCPyV-driven MCC, to provide an overview of current findings on how MCPyV is involved in the dysregulation of these epigenetic processes. The current state of the art is also described as far as potentially using epigenetic dysregulations and related factors as diagnostic and prognostic tools is concerned, in addition to targets for MCPyV-driven MCC therapy. Growing evidence suggests that the dysregulation of HPTMs, DNA methylation, and miRNA pathways plays a role in MCPyV-driven MCC etiopathogenesis, which, therefore, may potentially be clinically significant for this deadly tumor. A deeper understanding of these mechanisms and related factors may improve diagnosis, prognosis, and therapy for MCPyV-driven MCC.
Bipolar Patients and Bullous Pemphigoid after Risperidone Long-Acting Injectable: A Case Report and a Review of the Literature

Neuropsychiatric disorders are found to be associated with bullous pemphigoid (BP), an autoimmune subepidermal blistering disease. Antipsychotics have emerged as possible inducing factors of BP. However, large sample studies concerning BP associated with antipsychotics, as well as with specific mental disorders, are still lacking. Our review retrieved a few clinical studies and case reports on the topic, producing controversial results. We report for the first time a bipolar patient case presenting BP following five-month therapy with risperidone long-acting injectable (LAI). We hypothesize that the dermatological event is associated with the medication administered. The issue emerged during psychiatric consultation and was confirmed by histological examination, direct and indirect immunofluorescence studies, plus positive plasma and cutaneous BP180 and BP230 IgG. Neurodegeneration or neuroinflammation might represent a primary process leading to a cross-reactive immune response between neural and cutaneous antigens and contributing to self-tolerance failure. Furthermore, the time sequence of the shared biological mechanisms leading to clinical manifestations of the neuropsychiatric disorder and BP remains undefined. BP comorbid with bipolar disorder might occasionally represent a serious health risk and affect patients’ physical and psychosocial quality of life. Thus, clinicians treating psychiatric patients should consider BP as a possible adverse effect of psychotropic medications.
Analysis of asymmetrical hysteresis phenomena observed in TMD-based field effect transistors

To realize field effect transistors with multi-layered MoS2 and WSe2 (hereafter denoted as MoS2 FET and WSe2 FET), many device instability problems should be surmounted, such as the hysteresis generation of the devices. In order to clarify the mechanism of the asymmetrical hysteresis phenomena observed in the transfer characteristics of the MoS2 and WSe2 FET, the temperature dependencies of their characteristics are analyzed. Based on these analyses, it can be concluded that donor-like traps present in both the SiO2/MoS2 interface and the MoS2 bulk in multi-layered MoS2 FETs, and that acceptor-like traps present in both the SiO2/WSe2 interface, and the WSe2 bulk in multi-layered WSe2 FETs. Furthermore, based on the chemical analyses and the arguments presented in previous studies, we propose that the sulfur vacancy (SV) is the origin of donor-like traps present in MoS2, and the tungsten vacancy (TV) is the origin of acceptor-like traps present in WSe2. This work may provide a potential clue to overcome many practical problems for realization of the transition metal dichalcogenides (TMDs) based FETs.To realize field effect transistors with multi-layered MoS2 and WSe2 (hereafter denoted as MoS2 FET and WSe2 FET), many device instability problems should be surmounted, such as the hysteresis generation of the devices. In order to clarify the mechanism of the asymmetrical hysteresis phenomena observed in the transfer characteristics of the MoS2 and WSe2 FET, the temperature dependencies of their characteristics are analyzed. Based on these analyses, it can be concluded that donor-like traps present in both the SiO2/MoS2 interface and the MoS2 bulk in multi-layered MoS2 FETs, and that acceptor-like traps present in both the SiO2/WSe2 interface, and the WSe2 bulk in multi-layered WSe2 FETs. Furthermore, based on the chemical analyses and the arguments presented in previous studies, we propose that the sulfur vacancy (SV) is the origin of donor-like traps present in MoS2, and the tungsten vacancy (TV) is the origin of acceptor-like traps present in WSe2. This work may provide a potential clue to overcome ma.
Biomass and essential oil of Tagetes minuta influenced by pinching and harvesting stage under high precipitation conditions in the western Himalayas

ABSTRACT A field experiment was conducted to study the effect of pinching and harvesting stages on duration of phenophases, aerial biomass partitioning, and essential oil productivity. It comprised of two pinching (pinching and without pinching) and four harvesting stages (bud initiation, flower initiation, 50% flowering and 100% flowering). All the phenological stages were delayed by pinching and the crop took 93–103 days, respectively, under control and pinching from transplanting to 100% flowering. Biomass accumulation in to leaf, flower and stem was enhanced by pinching. Pinching and 100% flowering stage recorded significantly higher fresh biomass and essential oil content than other treatments. Delay in harvesting stage from bud initiation to 100% flowering also caused variation in oil content and composition. Major constituents of essential oil (Z)-β-ocimene and (E)-ocimenone increases, while dihydrotagetone and (E)-tagetone decreases with delay in harvesting from bud initiation to 100% flowering stage.
Storage Studies of Low Salt Pork Sausages and Low Salt Pork Curry Under Refrigerated Conditions

Meat and meat products are important sources of proteins and essential amino acids, fats, iron, zinc, conjugated linoleic acid and B1, B2, B6 and B12 vitamins. However meat consumption had been criticized because it contains high levels of sodium and fat and also little or no fibre or calcium. Meat contains 5090 mg of sodium per 100gms of meat but processed meat products contribute rather a high amount of sodium than this. Usually 2.04. 0% sodium chloride is added to sausage mince and these values increase in final product to drying process. In addition to sodium chloride other salts such as nitrite, ascorbate, and erythroborate may provide sodium (Stahnke and Tjener, 2007).
Constructing a precipitable water vapor map from regional GNSS network observations without collocated meteorological data for weather forecasting

Abstract. Surface pressure (Ps) and weighted mean temperature (Tm) are two necessary variables for the accurate retrieval of precipitable water vapor (PWV) from Global Navigation Satellite System (GNSS) zenith total delay (ZTD) estimates. The lack of Ps or Tm information is a concern for those GNSS sites that are not collocated with meteorological sensors. This paper investigates an alternative method of inferring accurate Ps and Tm at the GNSS station using nearby synoptic observations. Ps and Tm obtained at the nearby synoptic sites are interpolated onto the location of the GNSS station by performing both vertical and horizontal adjustments, in which the parameters involved in Ps and Tm calculation are estimated from ERA-Interim reanalysis profiles. In addition, we present a method of constructing high-quality PWV maps through vertical reduction and horizontal interpolation of the retrieved GNSS PWVs. To evaluate the performances of the Ps and Tm retrieval, and the PWV map construction, GNSS data collected from 58 stations of the Hunan GNSS network and synoptic observations from 20 nearby sites in 2015 were processed to extract the PWV so as to subsequently generate the PWV maps. The retrieved Ps and Tm and constructed PWV maps were assessed by the results derived from radiosonde and the ERA-Interim reanalysis. The results show that (1) accuracies of Ps and Tm derived by synoptic interpolation are within the range of 1.7–3.0 hPa and 2.5–3.0 K, respectively, which are much better than the GPT2w model; (2) the constructed PWV maps have good agreements with radiosonde and ERA-Interim reanalysis data with the overall accuracy being better than 3 mm; and (3) PWV maps can well reveal the moisture advection, transportation and convergence during heavy rainfall.
Postharvest quality and safety of fresh-cut melon fruits coated with water soluble chitosan films

The research presents the effect of novel edible coatings based on low molecular weight chitosan on some properties of fresh-cut melon fruits – weight loss, total soluble solids, total acidity, mechanical strength and bacteria growth. Three different compositions were used as coatings – pure chitosan, chitosan and Ca lactate and alginate/chitosan multilayers. It was shown that the additional alginate layer substantially improves the protective properties of pure chitosan coating, resulting in preservation of cell structure. Negligible negative effect on the antibacterial activity of pure chitosan is demonstrated.
Liquefaction Behaviors of Oil Palm Frond and Bamboo in 1-Butyl-3-Methylimidazolium Chloride

Oil palm and bamboo are two of the most widely used biomass in the world nowadays as they can be converted into many valuable products. However, they are very difficult to be hydrolyzed and converted into other products because of their tight and strong hydrogen bonding between the lignin and polysaccharides. Ionic liquid (IL) is said to be the most ideal solvent to dissolve those biomass. Thus, in this research, 1-butyl-3-methylimidazolium chloride ([BMIM][Cl]) was chosen to liquefy oil palm frond (OPF) and bamboo. The objective of this research was to compare the reaction behaviors of OPF and bamboo in [BMIM][Cl] at different treatment time. OPF and bamboo were heated at 120 °C for 2-24 hours under atmospheric pressure. Two fractions were obtained, namely [BMIM][Cl]-soluble and -nonsoluble. The non-soluble fractions were characterized using TGA, FTIR, XRD and FESEM while the soluble fractions were analyzed using HPLC. Based on the results obtained from the analyses, the effectiveness of [BMIM][Cl] in dissolving OPF was higher than bamboo as it was made up of less complex and compact cell wall structure. This structure allowed the diffusion of [BMIM][Cl] into the interior of OPF more easily to break down the hydrogen bonding network. Holocelluloses and lignin of OPF solubilized into [BMIM][Cl] more rapidly due to the greater distortion in hydrogen bonding network of the cell wall with the increase in treatment time compared to bamboo. Moreover, the mono-sugars of OPF were formed much easily than bamboo after short period (2 hours) of treatment. Copyright © 2018 BCREC Group. All rights reservedReceived: 28th November 2017; Revised: 4th June 2018; Accepted: 9th June 2018How to Cite: Tai, Z.S. , Asmadi, M. , Ali, N. (2018). Liquefaction Behaviors of Oil Palm Frond and Bamboo in 1-Butyl-3-Methylimidazolium Chloride. Bulletin of Chemical Reaction Engineering & Catalysis, 13 (3): 447-455 (doi:10.9767/bcrec.13.3.1085.447-455)Permalink/DOI: https://doi.org/10.9767/bcrec.13. 3.1085. 447-455
Presence of Incomplete Superficial Axillary Arch and Pectoralis Quartus Muscle in One Male Body

The anatomical variations of the pectoralis major muscle (PMM) and latissimus dorsi muscle (LDM) range from agenesis to the presence of supernumerary fascicles with a variety of insertions and relationships with the muscles, fascia, ve s els, nerves and skeletal components of the shoulder girdle and the axilla. Many of these variations are clinically irrelevant, but extremel y interesting and revealing from the perspective of comparative anatomy, ontogeny, and phylogeny. In this report, we present two different su pernumerary muscles in the chest of one adult male body, identified during dissection practice of undergraduate medical students at Univers id d Surcolombiana. These supernumerary fascicles in the axillary region were caudal to the lower edge of the PMM on the right side of the chest, and in contact with the anterior edge of the LDM on the left side of the chest; each fascicle was inserted in the ipsila teral coracoid process. These observations are congruent with the pectoralis quartus muscle and an incomplete and superficial axillary arch, respectively.
Food Science of Animal Resources

This study investigated the amino acid and nucleotide-related compound composition and taste characteristics of cultured muscle tissue (CMT) obtained by culturing satellite cells isolated from chicken and cattle and compared them to those of traditional meat (TM). The content of all amino acids except valine and tyrosine was significantly different between CMT and TM (p<0.05). The amount of glutamic acid was not significantly different between CMT and TM in cattle, but the glutamic acid in chicken CMT was lower than that of TM (p<0.05). Among the nucleotide-related compounds, only the content of inosine-5'-monophosphate (IMP) was significant, and the amount of IMP in CMT derived from chicken and cattle was significantly lower than that of TM (p<0.05). There were significant differences in the taste characteristics assessed by an electronic tongue system, and the umami, bitterness, and sourness values of CMT were significantly lower than those of TM from both chicken and cattle (p<0.05). The results of the present study suggest that it is necessary to develop a satellite cell culture method that could increase the umami and bitterness intensity of CMT and adjust the composition of the growth medium to produce cultured meat with a taste similar to that of TM.
Coupling processes of various timescales in the middle atmosphere

The thesis deals with the manifestation of coupling processes of various timescales in the middle atmosphere. Longer and shorter timescales are represented here by the 11-year solar cycle (SC) and orographic gravity waves (oGWs) considered on the intraseasonal timescale of the north hemisphere winter, respectively. The first two chapters deal with the application of rigorous attribution the variability of temperature, ozone and circulation characteristics in the stratosphere and lower mesosphere with regard to the SC using multiple nonlinear techniques (support vector regression and neural networks) besides the multiple linear regression approach. The aliasing of the SC with volcanic eruptions or the El Niño Southern Oscillation is qualitatively assessed and its impact on conclusions about the top-down coupling mechanisms discussed. The last chapter examines the role of parametrized oGWs in the lower stratosphere. The Himalayan hotspot reveals common features with sudden stratospheric warmings such as the residual circulation amplification leading to a warming and ozone enrichment in the polar latitudes of the lower stratosphere.
Two Simultaneously Occurring Potamogeton
Species: Similarities and Differences in Seasonal
Changes of Biomechanical Properties

Two common Potamogeton species, Potamogeton pectinatus L. and Potamogeton crispus L. , were collected in 2016 and 2017 from a lowland, sandy bed in the Wilga River in Poland to investigate the ability of the plants to adapt to changing hydrological conditions. Measurements included biomechanical properties as well as the morphological characteristics of their stems. Specifically, experiments included three-point bending and tension tests as well as stem diameter and cross-sectional morphology at various periods in the plants’ life cycles. Detailed information about the seasonal changes in biomechanical traits and the similarities between the two investigated plants are presented. The data show significant differences in the three-point bending and tension parameters. The flexural rigidity proved to be the most sensitive parameter to changes in hydrological conditions during the season. The maximum forces in the three-point bending tests needed to complete the fracture of P. crispus were much higher, reaching values up to 0.097 N, than those for P. pectinatus (0.035 N), due to P. crispus having thicker shoots, which resulted in greater resistance to elastic deformity. Moreover, the modulus of elasticity values shows that P. pectinatus is much more prone to return to its original shape after the removal of the acting forces. For instance, the maximum Young’s modulus for P. pectinatus was 116.23 MPa, whereas for P. crispus, the highest value was four times lower (26.60 MPa). The present study supplements an aquatic plant biomechanics database that has been created in recent years.
Synthesis of Calcium Phosphate Bioceramics Based on Snail Shells: Towards a Valorization of Snail Shells from Republic of Benin

In this study, we used Lanistes varicus and Achatina achatina snail shell powders as a calcium source for the synthesis of calcium phosphate bioceramics by using coprecipation method and microwave irradiation method. X-Rays Diffraction Analysis, Thermal Analysis (TGA), Acid-Base back titration method and FTIR analysis of the powders of the snail shells revealed that they contain more than 98% of calcium carbonate CaCO 3 with aragonite as the major phase. Structural characterization and elucidation of synthesized bioceramics were done using X-Rays diffraction analysis, Scanning Electron Microscopy (SEM) and Fourier Transform Infrared Spectroscopy (FTIR) analysis. The results have revealed that synthesized calcium phosphate bioceramics contain a mixture of Hydroxyapatite (HA: Ca 10 (PO 4) 6 (OH) 2) and apatitic Tricalcium Phosphate (TPa: Ca 9 (HPO 4) (PO 4) 5 (OH) whatever the method of synthesis. and the variety of snail shell used. The study of the antibacterial activity of synthesized bioceramics has shown that only those obtained with Lanistes varicus powder significantly inhibit the growth of Staphylococcus aureus with a lasting effect. On the other side, inhibition of growth of Klebsiella oxytoca is partial and a resistance to the antimicrobial activity of bioceramics was noticed. Thus bioceramics synthesized from Lanistes varicus snail shell powder has antibacterial property and should be used against the growth of pathogens causing dental cavities.
Environmental Evolution of Long-Lived Supercell Thunderstorms in the Great Plains

Long-lived supercells (containing mesocyclones persisting for at least 4 hours) are relatively rare, but present significant risk for society as a result of their intensity and associated hazards over an extended time period. The persistence of a rotating updraft is tied to near-storm environmental characteristics; however, given the established prevalence of mesoscale environmental heterogeneity near severe convection, it is unknown to what extent those near-storm characteristics vary over the lifetime of a supercell, nor how quickly the storm responds to such changes. This study examines 147 long-lived, isolated supercells, focusing on the evolution of their near-storm environments using model analysis soundings generated each hour throughout the storm’s lifetime. Environmental variability is quantified via a series of common forecasting parameters, with impacts of measured changes related to production of severe weather and overall storm longevity. The diurnal and maturity-relative distributions of forecasting parameters are examined, along with comparisons among subsets of marginally vs. very long-lived supercells, as well as dissipation before vs. after sunset. The diurnal cycle is a dominant trend over the lifetime of all supercells, with attendant impacts to relevant thermodynamic and kinematic parameters, timing of storm initiation and dissipation, as well as severe weather production. Notably, changes in the near-storm environment are connected to supercell longevity and generation of severe weather reports. The long-term goal of the above analyses is to enhance short-term forecasts of supercells by better anticipating storm evolution as a result of environmental variations.
Can urban parks bridge deep divides? Assessing the effects of inter-racial social interaction in parks and public spaces on trust

Abstract The ability of urban parks and public spaces to address distrust and social isolation needs to be rigorously tested, as the predominance of such claims may crowd out discussions of environmental racism and structural inequality. This study tested some commonly stated claims about parks’ influence on social well-being using a survey of residents in St. Louis, Missouri. We tested relationships between park and public space visitation frequency, positive and negative social contact with people of other races/ethnicities, and trust, using structural equation modeling. The model had strong fit but had few significant paths, indicating assertions are not fully supported by our data. Recommendations for urban park planners, managers, and community advocates include improving the design and planning process to accommodate diverse users, as well as modifying their discourse to reflect the growing need for social equity.
Nutritional Value and Volatile Composition of Leaf and Bark of Cinnamomum tamala from Uttarakhand (India)

Abstract Cinnamomum tamala leaf and bark are very popular for their used as spices due to its spicy odour. The plant leaf and bark are also used widely in pharmaceutical preparation because of therapeutic and nutritive efficacy against various diseases and disorders due to presence of different phytochemicals and mineral nutrients. The leaf and bark samples of C. tamala were collected from Uttarakhand and cinnamon bark from market and analyzed for proximate, minerals content and essential oil compositions. The results revealed that the C. tamala leaves and bark collected from Uttarakhand was the most superior in proximate values (total ash, dietary fibre, protein and fat content), vitamins (ascorbic acid, niacin and traces in riboflavin and folates) and minerals nutrients content (macro nutrients like Ca, Mg, P, K and Na and micro nutrients like Fe and Zn content) as compared to leaf and bark samples collected from the market. Whereas, in case of essential oil composition, both leaf and bark samples of C. tamala collected from Uttarakhand and bark samples C. tamala collected from market were found rich in cinnamaldehyde (68.66%, 64.79% and 90.48% respectively), while, leaf samples of C. tamala collected from market was rich in eugenol (72.6%).
Estimation of Life Expectancy for Dependent Population in a Multi-State Context

Population statistics show that there was an increase in life expectancy during the last century. However, this fact hides that this increase was not equal for all groups of the population. One of the most problematic cases for measuring this increase is that of the dependent population because of the absence of specific statistics. This paper describes a methodology for calculating life expectancy using multistate models that take into account the diversity of situations considered by Spanish legislation. For this purpose, statistical information contained in the national survey on disability and dependency (EDAD 2008) is used. The results suggest that life expectancies are lower than those of the general population and that they differ according to gender and intensity of suffering from this contingency. The calculations were made considering the legal framework currently existing in Spain. This fact conditions the definition of dependent person and, therefore, the set of individuals, their characteristics, and therefore, their final results.