Miracle-dz/UniFAR-FTUs huggingface dataset:
Effects of Protein Hydrolysate from Silkworm (Bombyx mori) pupae on the C2C12 Myogenic Differentiation

This study investigated the effects and active compounds of silkworm pupae, an edible insect, on C2C12 muscle differentiation. The protein of silkworm pupae was extracted using sonication after defatting with hexane. Subsequently, the extract was rehydrated using Alcalase to obtain a protein hydrolysate. The silkworm pupae protein hydrolysate effectively promoted C2C12 myogenic differentiation without cytotoxicity. Subsequently, the hydrolysate was fractionated into four subfractions using preparative high-performance liquid chromatography (Prep-HPLC). Subfraction 1 was the most effective in promoting C2C12 myogenic differentiation and significantly upregulated the expression of myoblast transcription factors, 1.5-fold of myoblast determination protein 1 (MyoD), 2-fold of myogenin, and 3-fold of myosin heavy chain (MyHC). Liquid chromatography–tandem mass spectrometry (LC-MS/MS) and multivariate statistical analysis were used to identify the active peptides in silkworm pupae responsible for the observed effects; then, dipeptides and essential amino acids, such as isoleucine (Ile), valine (Val), and methionine (Met), were identified. In addition, Val, Ile, and two dipeptides underwent quantification to determine the potential bioactive peptides that enhanced C2C12 myogenic differentiation. This study suggests that the peptides from silkworm pupae could be used as a nutraceutical to enhance muscle growth.
An Analysis of Coordinated Observations from NOAA’s Ronald H. Brown Ship and G-IV Aircraft in a Landfalling Atmospheric River over the North Pacific during CalWater-2015

AbstractTo gain a more complete observational understanding of atmospheric rivers (ARs) over the data-sparse open ocean, a diverse suite of mobile observing platforms deployed on NOAA’s R/V Ronald H. Brown (RHB) and G-IV research aircraft during the CalWater-2015 field campaign was used to describe the structure and evolution of a long-lived AR modulated by six frontal waves over the northeastern Pacific during 20–25 January 2015. Satellite observations and reanalysis diagnostics provided synoptic-scale context, illustrating the warm, moist southwesterly airstream within the quasi-stationary AR situated between an upper-level trough and ridge. The AR remained offshore of the U.S. West Coast but made landfall across British Columbia where heavy precipitation fell. A total of 47 rawinsondes launched from the RHB provided a comprehensive thermodynamic and kinematic depiction of the AR, including uniquely documenting an upward intrusion of strong water vapor transport in the low-level moist southwesterly flow.
Senolytic therapy is neuroprotective and improves functional outcome long-term after traumatic brain injury in mice

Introduction Chronic neuroinflammation can exist for months to years following traumatic brain injury (TBI), although the underlying mechanisms remain poorly understood. Methods In the current study, we used a controlled cortical impact mouse model of TBI to examine whether proinflammatory senescent cells are present in the brain long-term (months) after TBI and whether ablation of these cells via administration of senolytic drugs can improve long-term functional outcome after TBI. The results revealed that astrocytes and microglia in the cerebral cortex, hippocampus, corpus callosum and lateral posterior thalamus colocalized the senescent cell markers, p16Ink4a or p21Cip1/Waf1 at 5 weeks post injury (5wpi) and 4 months post injury (4mpi) in a controlled cortical impact (CCI) model. Intermittent administration of the senolytic drugs, dasatinib and quercetin (D + Q) beginning 1-month after TBI for 13 weeks significantly ablated p16Ink4a-positive- and p21Cip1/Waf1-positive-cells in the brain of TBI animals, and significantly reduced expression of the major senescence-associated secretory phenotype (SASP) pro-inflammatory factors, interleukin-1β and interleukin-6. Senolytic treatment also significantly attenuated neurodegeneration and enhanced neuron number at 18 weeks after TBI in the ipsilateral cortex, hippocampus, and lateral posterior thalamus. Behavioral testing at 18 weeks after TBI further revealed that senolytic therapy significantly rescued defects in spatial reference memory and recognition memory, as well as depression-like behavior in TBI mice. Discussion Taken as a whole, these findings indicate there is robust and widespread induction of senescent cells in the brain long-term after TBI, and that senolytic drug treatment begun 1-month after TBI can efficiently ablate the senescent cells, reduce expression of proinflammatory SASP factors, reduce neurodegeneration, and rescue defects in reference memory, recognition memory, and depressive behavior.
Performance of a magnetorheological fluid-based robotic end effector

Robotic end effectors are needed for a variety of terrestrial and space-based tasks. End effectors are commonly inspired by the human hand, with a range of complexity, including varying number of fingers, joints and degrees of freedom. Hand and pincher-type grippers can require complicated actuation and/or a significant sensing and control system to ensure proper orientation of the gripper about the target prior to gripping as well as to avoid crushing the target. Universal grippers, most notably exemplified by the universal Jamming Gripper (Brown et al 2010 Proceedings of the National Academy of Science 107, 18809–18814), provide an alternative design that aims to simplify the actuation, sensing and control of robotic fixturing end-effectors. The universal Jamming Gripper is actuated pneumatically, by applying vacuum to granular media, thereby causing the grains to jam, when confined by an external bladder. We present the design and performance of a universal gripper that is actuated by applying a magnetic field, thereby eliminating the need to supply vacuum (and a reinflation source) to actuate the gripper. The magnetic field actuates a magnetorheological fluid composed of a bi-disperse mixture of carbonyl iron grains suspended in a silicone oil. The performance of this novel gripper design is characterized for a range of target sizes and shapes, and gripper design characteristics.
The mediating effect of stigma between self-perceived burden and loneliness in stroke patients

Introduction Stroke patients may experience reduced socialization and feelings of isolation due to post-stroke sequelae such as impaired motor function and cognitive deficits. Factors associated with loneliness need to be explored to develop targeted interventions. However, little is known about the impact of self-perceived burden and illness stigma on loneliness in this population.The aim of this study was to explore the mediating effect of stigma on self-perceived burden and loneliness in stroke patients. Methods The cluster random sampling method was adopted to select 1028 stroke patients from the neurology department of third-grade A hospitals and second-grade A hospitals in 5 cities of Henan Province from May 2022 to August 2022. A general data questionnaire, self-perceived burden scale, stroke stigma scale, and loneliness scale were used to investigate. The structural equation model was used to analyze the mediating effect of stigma between self-perceived burden and stigma. Results The loneliness of stroke patients was positively correlated with self-perceived burden and stigma. The results of the mediation analysis showed that stigma played a complete mediating role between self-perceived burden and loneliness. Discussion The results of the study revealed the relationship between self-perceived burden, stigma, and loneliness in stroke patients. Stigma mediated the relationship between self-perceived burden and loneliness in this population.Stigma should be emphasized as an important modifiable psychological factor that affects loneliness of stroke patients.
Analisis faktor-faktor yang mempengaruhi struktur modal

The capital structure balances external (long-term) capital with internal capital. This research aims to find out the effect of liquidity, uniqueness and profitability on the capital structure of food and beverage subsector companies listed on the Indonesia Stock Exchange from 2014 to 2018. The research sample used consisted of 7 companies listed on the Indonseia Stock Exchange, sampling targets set certain standards for 5 years, and the amount of data of 35 companies. Data analysis methods use multiple regressions. The results of this study show that liquidity variables affect the structure of capital. This is because liquid companies tend to use relatively small amounts of debt for their working capital and can meet their financing needs, but unique variables affect the capital structure. The uniqueness of the company's products leads to high costs, so more capital is used and fluctuating profitability does not affect the capital structure. The decline in sales led to a decrease in the company's sales.
Impact of Flavor and Higgs Physics on Theories Beyond the Standard Model

Quantum effects of physics beyond the Standard Model receive strong indirect constraints from precisely measured collider observables. In the conceptual part of this thesis, we apply the generic relations between particle interactions in perturbatively unitary theories to calculate one-loop amplitudes for flavor physics. We provide template results applicable for any model of this class. We also investigate example models that are partly and such that are not perturbatively unitary: the Littlest Higgs model and Randall-Sundrum models. The latter have a unique coupling structure, which we cover exhaustively. We find strong constraints on the Randall-Sundrum models and numerically compare those from flavor, electroweak precision, and Higgs physics by performing detailed parameter scans. We observe interesting correlations between flavor observables, and we find that constraints from Higgs production and decays are already competitive.
Observer-Based Adaptive Sliding Mode Control for T–S Fuzzy Singular Systems

This paper investigates the problem of adaptive <inline-formula> <tex-math notation="LaTeX">${H}_{\infty}$ </tex-math></inline-formula> sliding mode control (SMC) for a class of nonlinear systems via Takagi–Sugeno (T–S) fuzzy model approach. The input matrices and output matrices in all local linear systems are different. A novel observer is designed to estimate the unmeasured states. Based on such an observer, the control input is only appeared in the T–S fuzzy singular system and error system. A new integral sliding surface is put forward to match the characteristic of T–S fuzzy singular system with different input and output matrices. Based on the new integral sliding surface, a new adaptive SMC scheme is designed to guarantee the admissibility of the T–S fuzzy singular system with <inline-formula> <tex-math notation="LaTeX">${H}_{\infty}$ </tex-math></inline-formula> performance and the reachability of the T–S fuzzy integral sliding surface. A simulation result is presented to illustrate the effectiveness and feasibility of the developed observer-based SMC design method.
Bootstrap Methods and their Application

This book gives a broad and up-to-date coverage of bootstrap methods, with numerous applied examples, developed in a coherent way with the necessary theoretical basis. Applications include stratified data; finite populations; censored and missing data; linear, nonlinear, and smooth regression models; classification; time series and spatial problems. Special features of the book include: extensive discussion of significance tests and confidence intervals; material on various diagnostic methods; and methods for efficient computation, including improved Monte Carlo simulation. Each chapter includes both practical and theoretical exercises. Included with the book is a disk of purpose-written S-Plus programs for implementing the methods described in the text. Computer algorithms are clearly described, and computer code is included on a 3-inch, 1.4M disk for use with IBM computers and compatible machines. Users must have the S-Plus computer application. Author resource page: http://statwww.epfl. ch/davison/BMA/
The Junta de Educação Nacional, Armando de Lacerda and the emergence of experimental phonetics in Portugal

: The work of the Junta de Educação Nacional from its creation in 1929 and the continuation of its work from 1936 by the body which replaced it, the Instituto para a Alta Cultura, meant that during the interwar period Portugal benefited from the existence of an institution for the planning and funding of science, similar to circumstances in other countries in Europe and North America. A number of Portuguese scientists were able to take advantage of scholarships granted by these bodies to study experimental phonetics at some of the most advanced research centres in Europe during the era, among them Armando de Lacerda, who in 1936, with the support of the Instituto para a Alta Cultura, set up the first experimental phonetics laboratory in Portugal, at the University of Coimbra – the Coimbra Phonetics Laboratory. The laboratory’s journal, the Revista do Laboratório de Fonética Experimental da Faculdade de Letras da Universidade de Coimbra , was published from 1952, and as its editor, Lacerda used it as a vehicle for disseminating the findings of the research carried out at the laboratory. The eight volumes of the Revista which were published contain works by several prominent 20 th -century phoneticians, such as Peter Ladefoged, Göran Hammarström and Peter Strevens. Their articles appeared in the journal at an early stage in their careers, indicating that they sought the recognition that the journal, the mouthpiece of the laboratory and its head, both of worldwide renown in the field of phonetics, conferred on them.
Shock parameter dependence of electron acceleration at quasi-perpendicular collisionless shock

Whistler waves are important in scattering and accelerating electrons in space. In the supercritical regime where the upstream Alfvén Mach number is above the so-called whistler critical Mach number, phase standing whistler waves can be excited and confined in the foot of the quasi-per-pendicular shocks. On the other hand, in the subciritical regime whistler wave trains are emitted toward the upstream of the shock. However, the electron acceleration efficiency related with the whistler critical Mach number is not understood well. Here we report new results from several 1D particle-in-cell simulations of quasi-perpendicular shocks above and below the whistler critical Mach number. In the subcritial regime, the simulation showed that high energy electrons penetrate upstream, and the density profile is similar to the standard diffusive shock acceleration. On the other hand, in the supercritical regime, the high-energy electrons are generated locally in the narrow regin of the foot or overshoot magnetic field. This is similar to electron spike events at the Earth’s bow shock and interplanetary shocks. Our result will give a new insight into the understanding of electron acceleration at collisionless shocks.
Enhancing Supplemental Effects of Acute Natural Antioxidant Derived from Yeast Fermentation and Vitamin C on Sports Performance in Triathlon Athletes: A Randomized, Double-Blinded, Placebo-Controlled, Crossover Trial

This study investigated the acute effects of natural antioxidants, derived from yeast fermentation containing glutathione and dietary vitamin C supplementation, on metabolic function, skeletal muscle oxygenation, cardiac function, and antioxidant function during submaximal exercise in middle-aged triathlon athletes. Twelve participants (aged 49.42 ± 5.9 years) completed 90 min submaximal cycling trials corresponding to 70% maximal oxygen uptake with either vitamin C and glutathione (VitC+Glu), vitamin C (VitC), glutathione (Glu) supplementation, or placebo. Metabolic function (minute ventilation, oxygen uptake, carbon dioxide output [VCO2], respiratory exchange ratio [RER], oxygen pulse [O2pulse], carbohydrate oxidation, fat oxidation, and energy expenditure), skeletal muscle oxygenation (oxidized hemoglobin and myoglobin in skeletal muscle tissue, total hemoglobin and myoglobin in skeletal muscle tissue [tHb]), cardiac function (heart rate [HR], stroke volume [SV], cardiac output, end-diastolic volume, end-systolic volume, and ejection fraction), and antioxidant function parameters (blood lactate, superoxide dismutase, catalase, glutathione peroxidases, glutathione [GSH], diacron reactive oxygen metabolite [dROM], and biological antioxidant potential [BAP]) were measured during submaximal exercise and recovery. VCO2, RER, HR, blood lactate after exercise, and dROM were significantly lower, and O2pulse, tHb, and BAP were significantly higher for VitC+Glu than for the other trials (p < 0.05). In conclusion, combined vitamin C and glutathione supplementation was more effective in improving metabolic function, skeletal oxygenation, cardiac function, and antioxidant function during prolonged submaximal exercise in middle-aged triathletes.
Children’s ‘eye views’ of an archaeological site: A multimodal social semiotic approach to children’s drawings

This paper presents eight-year-old children's ‘eye views’ of the archaeological site of the Agora in Athens, Greece, based on drawings made during an educational programme on site. Complementing a significant body of research on drawings, we introduce a multimodal social semiotic perspective to explore drawings as ‘designed’ accounts of children’s ‘eye views’. We argue that each account arises as an agentive response to their interests and prompts in the environment framing their experience, such as features of the site and the educational programme. Based on four drawings, we identify salient elements of children’s experience in their representations which we analyze as material realizations of (i) their interests and agency, (ii) their visual and embodied engagement with the archaeological site, and (iii) the framing of the educational task and overall programme. Our findings contribute to research on the importance of visual in learning.
Kemampuan Pemecahan Masalah Matematis dan Adversity Quotient Siswa SMP Melalui Pembelajaran Open Ended

Abstrak. Adversity quotient dan kemampuan pemecahan masalah matematis menjadi salah satu faktor dalam pencapaian tercapainya tujuan pendidikan matematika. Penelitian ini bertujuan untuk mendeskripsikan kemampuan pemecahan masalah matematis dan adversity quotient dalam menyelesaikan soal cerita mengenai keliling dan luas bangun datar. Metode penelitian yang digunakan adalah metode deskriptif kualitatif. Subjek penelitian ini adalah 35 siswa di kelas VIII-B di salah satu SMP di Kabupaten Bandung Barat. Hasil dari penelitian menunjukan bahwa (1) Kemampuan pemecahan masalah matematika siswa SMP pada materi keliling dan luas persegi panjang dengan pembelajaran open ended mencapai ketuntasan belajar; (2) Siswa AQ quitters dalam memecahkan masalah mampu memahami masalah dengan menuliskan apa yang diketahui dan apa yang ditanyakan dan menjelaskan masalah dengan kalimat sendiri; (3) Siswa AQ campers dalam memecahkan masalah mampu melaksanakan tiga tahapan Polya yaitu memahami masalah, merencanakan pemecahan, dan melaksanakan rencana; Siswa AQ climbers dalam memecahkan masalah mampu melaksanakan keempat tahap Polya yaitu mampu memahami masalah, merencanakan pemecahan masalah, menyelesaikan masalah melalui strategi pemecahan masalah, serta memeriksa kembali hasil dan proses dan menyimpulkan hasil penyelesaian. Kata Kunci: Adversity quotient, Open Ended , Pemecahan Masalah Matematis. Abstract. Adversity quotient and mathematical problem solving ability become one of the factors in achieving the goal of mathematics education. This study aims to describe the ability to solve mathematical problems and adversity quotient in solving the story about the circumference and the area of flat wake. The research method used is qualitative descriptive method. The subject of this research is 35 students in class VIII-B in one of junior high school in West Bandung regency. The result of the research shows that (1) the ability of problem solving of mathematics of junior high school students on material around and rectangular area with open ended learning achieve learning mastery; (2) AQ quitters students in solving problems are able to understand the problem by writing down what is known and what is being asked and explaining the problem with their own sentences; (3) AQ campers students in solving problems are able to carry out three stages of Polya namely understanding the problem, planning the solution, and implementing the plan; AQ climbers students in solving problems are able to implement the four stages of Polya that is able to understand the problem, plan problem solving, solve problems through problem solving strategies, and re-examine the results and processes and conclude the outcome. Keywords. Adversity quotient, Open Ended, Mathematical Problem Solving
Annealing temperature and thickness dependencies of structural and magnetic properties of Co 2 FeAl thin films

Annealing temperature and thickness dependencies of structural and magnetic properties of Co2FeAl thin films M. Belmeguenai,1,* M. S. Gabor,2,† F. Zighem,1 Y. Roussigné,1 D. Faurie,1 and C. Tiusan2,3 1LSPM-CNRS, Université Paris XIII-Sorbonne Paris Cité, F-93430 Villetaneuse, France 2Center for Superconductivity, Spintronics and Surface Science, Technical University of Cluj-Napoca, Strada Memorandumului No. 28, RO-400114 Cluj-Napoca, Romania 3Institut Jean Lamour, CNRS, Université de Nancy, BP 70239, F-54506 Vandoeuvre, France (Received 20 May 2016; revised manuscript received 5 September 2016; published 22 September 2016)