Miracle-dz/UniFAR-FTUs huggingface dataset:
Effect of Pyridoxine on Prostaglandin Plasma Level for Primary Dysmenorrheal Treatment

Objective : To determine the effect of vitamin B6 (pyridoxine) the levels of prostaglandins and intensity of pain in primary dysmenorrheal. Methods : The levels of prostaglandin (PGF2Î±) in plasma measured by ELISA and pain intensity by verbal rating scales conducted on 35 women with primary dysmenorrheal (n=35) supplemented with vitamin B6 100mg for 4 days and controls with placebo (n=35). Results : Prostaglandin levels decreased significantly after vitamin B6 supplementation (2212.9+1374.2 vs 1490.3+1119.0; p<0.05) followed by a significant reduction in pain intensity (4.29+0.7 vs 1.71+0.5; p<0.05) in the test group compared to control. Conclusion : Due to vitamin B6 effects on decreasing prostaglandin levels and pain of primary dysmenorrheal, so that B6 vitamin can become the treatment for the primary dysmenorrheal. Keywords : Primary dysmenorrheal, pyridoxine, prostaglandin Tujuan: Untuk mengetahui pengaruh pemberian vitamin B6 (piridoksin) terhadap kadar prostaglandin dan intensitas nyeri pada dismenore primer. Metode: Pemeriksaan kadar prostaglandin (PGF2Î±) dengan ELISA dan pengukuran intensitas nyeri dengan verbal rating scales dilakukan pada 35 orang (n=35) wanita dengan dismenore primer yang mendapatkan vitamin B6 100mg selama 4 hari dan kontrol yang mendapatkan plasebo (n=35). Hasil: Kadar prostaglandin menurun bermakna setelah pemberian vitamin B6 (2212,9+1374,2 vs 1490,3+1119,0; p<0,05) disertai dengan penurunan intensitas nyeri yang bermakna (4,29+0,7 vs 1,71+0,5; p<0,05) pada kelompok uji dibandingkan kontrol. Kesimpulan: Vitamin B6 menurunkan kadar prostaglandin dan nyeri sehingga vitamin B6 dapat dipertimbangkan menjadi salah satu pengobatan dismenore primer. Kata kunci : Dismenore primer, piridoksin, prostaglandin
Treatment of glioblastoma by photodynamic therapy with the aid of synthesized silver nanoparticles by green chemistry from Citrus aurantium

: Blood brain barrier is very important to provide treatment locally for the treatment of glioblastoma. The use of nanoparticles has shown promise for glioblastoma treatments in recent years. In this study, the effect of the combined treatment of silver nanoparticles (AgNPs) synthesized from Citrus aurantium with photodynamic therapy (PDT) was investigated on U87 glioblastoma cells. AgNPs were characterized by FTIR, zeta potential and SEM images. U87 cells were treated with AgNPs (10 µg/mL) and/or PDT (0.5 mJ/cm 2 ) at 24 h. Cells antiproliferative effect, migration levels, colony formation capability, Bax and Bcl-2 protein/gene expression, and caspase-3 activity levels as apoptotic markers were measured. AgNPs size were found at 141±3 nm and 18.1±1.3 mV as zeta potential. It was found that cell proliferation, migration and Bcl-2 protein/gene levels decreased, and Bax protein/gene levels and caspase-3 activity increased via AgNPs and PDT combined treatment. As a result, nanoparticles synthesized from Citrus aurantium are eco-friendly and their size can cross the blood brain barrier. If AgNPs is used with PDT, it may be a new therapy for clinically treatment of glioblastoma in the future.
Physical and functional properties of ancient grains and flours and their potential contribution to sustainable food processing

ABSTRACT Sustainable agricultural practices supporting food diversification and value addition of underutilized crops can support global food security and nutrition. Rediscovered ancient seed grains and flours (barnyard millet, finger millet, little millet, sorghum) are emerging as sustainable alternatives due to high nutritional content and climate resilience. The physical and functional properties varied significantly (p < 0.05) among seed grains and flours in this observational study. All the tested grains showed good antioxidant activity due to a good phenolic content. Understanding these properties is essential for food processing operations. This study indicates that millet and sorghum could be used successfully in food products formulation. Graphical Abstract
Overall survival in patients with acute lymphoblastic leukemia treated with CALGB 8811 protocol in low income country

Introduction: ALL is known to have a lower survival rate in adults and this can be attributed, among other aspects, to intolerance to intensive regimens. As the treatment of ALL is very complex, with many protocols available, this study proposes an analysis regarding the CALGB 8811 protocol in a tertiary health unit in Ceará Methods: In this retrospective study, 50 patients with a recent diagnosis of ALL who underwent the CALGB8811 protocol were evaluated. Disease risk criteria were based on the CALGB8811 protocol. Results: CR was obtained in 86% of patients. 12% of patients died during induction due to infectious complications. 30% of patients underwent alloSCT, 60% were on CR1. The median overall survival (OS) was 21.5 months (8.1-38.7). The 5 years OS was 25% in the transplanted patients versus 60% in the transplanted group. Achieving complete remission after induction chemotherapy and allogeneic hematopoietic stem cell transplantation were the factors associated with better long-term survival rates in uni and multivariate analysis. Conclusion: Risk factors classically associated with worse adult ALL outcome and post-induction MRD status were not outcome predictors, in addition, post-induction remission and alloSCT were factors associated with a favorable outcome.
Determination of important enzymes and antimicrobial resistances of gram-positive haloalkaliphilic bacteria isolated from Salda Lake

As an extreme environment, soda lakes harbor various haloalkaliphilic microorganisms. Salda Lake is one of the natural soda lake (pH˃9) in Turkey. Haloalkaliphiles are unique microorganisms in their ability to live in high alkaline and high saline conditions, and play an important role in biodegradation and bioremediation of hydrocarbons. Hence, the aims of this study were to isolate haloalkaliphilic bacteria from water sample of Salda Lake, to identify these isolates by both conventional and molecular methods, to screen their industrially important enzymes, and to investigate their antimicrobial resistance profiles. Six isolates were identified as Bacillus horneckiae, Bacillus subtilis, Bacillus paramycoides, Bacillus pumilus, Staphylococcus epidermidis, Bacillus haynesii according to 16S rRNA gene sequencing analysis. The industrially important enzymes (amylase, cellulase, pullulanase, lipase, urease, protease, caseinase, oxidase, catalase) were produced by haloalkaliphilic isolates. These enzymes maybe used in alkaline and saline industrial processes. Although Bacillus subtilis was susceptible to all antibiotics, other isolates showed resistance to at least one antibiotic. The resistance against antibiotics were found as ampicillin/sulbactam 83%, amoxycillin/clavulanic acid 83%, ampicillin 67%, mupirocin 67%, chloramphenicol 50%, tetracycline 50%, imipenem 50%, meropenem 50%, cefadroxil 17%. These bacteria may have develope resistance to antibiotics that entering their natural environment in different ways.
Providing A Model for Predicting and Detecting Destructive Processes to Prevent the Production of Waste and Defective Products: A Data Mining Approach

Today, most industries use statistical quality control tools to improve quality and reduce the defective products and waste, but the high volume of data requires the help of a powerful tool to control processes. One of the objectives of the present study is to predict defective products and prevent their production using data mining tools due to the high power in data analysis and its predictive nature, which is less used in the industry. In this study, the statistical population of all parts produced in 2017 by Shabrun Company. The statistical sample is 2400 pieces of radiators that were randomly selected from the production line. In the operational phases of data mining, three decision tree algorithms were used: C&R Tree, Quest Tree and Chaid Tree. Using these algorithms, the most important criteria affecting quality control and rules leading to the quality of parts were determined. Comparative results showed that despite the validity of all three algorithms, the C&R Tree algorithm had the highest accuracy. Adherence to the rules resulting from the implementation of these algorithms has led to the detection and prevention of waste generation, which has increased efficiency and prevented the loss of time and cost in this production unit.
May lichen biomonitoring of air pollution be used for environmental justice assessment? A case study from an area of N Italy with a municipal solid waste incinerator

Abstract In this work, we aimed to identify the contribution of a municipal solid waste incinerator (MSWI) to the air contamination of a complex urbanized area of N Italy using lichen transplants as biomonitors, and to compare the values of contamination with the data of socio-economic deprivation of the population living in the area. The method adopted allowed the identification of the elements of atmospheric origin that contaminate the study area. Although not distinguishable from the background, the contribution of the MSWI could be apportioned and mercury emerged as atmospheric tracer. Although not posing immediate risk, it is advisable to monitor in time the accumulation of Hg in biological systems. Consistently with similar studies, in the surrounding of the MSWI, we observed also the highest socio-economic deprivation. Overall, we found a close correlation between socio-economic deprivation and air pollution, clearly showing that the most disadvantaged population is clustered in the most polluted areas.
The effect of insole on the knee valgus angle and pelvic muscle activity 
during high-intensity weight-bearing tasks

Introduction. The purpose was to investigate changes in knee valgus angle, as well as associated pelvic muscles, gluteus medius and tensor fasciae latae, when using an insole in people with leg length mismatch less than 2 cm in high-intensity weight-bearing tasks. Methods. The knee valgus angle, muscle activity of the gluteus medius, and muscle activity of the tensor fasciae latae were measured with and without an insole during a drop jump task and a step landing task. All measurements were performed 3 times, and the average value was used. The subjects practised 3 times before the measurement and took a sufficient rest between each measurement. Results. There was no significant difference between the knee valgus angles with or without an insole during the drop jump task or step landing task. For the drop jump task, a significant difference was observed in the muscle activity of the tensor fasciae latae on the short leg side; for the step landing task, a significant difference was noted in the muscle activity of the gluteus medius on the long leg side ( p < 0.05). Conclusions. The use of insoles by people with leg length discrepancy during high-intensity landing may prevent non-contact anterior cruciate ligament damage, which is frequently seen in high-intensity landings.
Motivation and Sense of Belonging in the Large Enrollment Introductory General and Organic Chemistry Remote Courses

The rapid shift from face-to-face to remote instruction in 2020 has resulted in recalibration of lecture and laboratory pedagogy. This research analyzed the impact of remote learning on student motivation and sense of belonging in large enrollment chemistry courses. Student responses were parsed according to specific demographics including gender, academic standing, first-generation status, and ethnicity. Research objectives included the analysis of how remote learning impacted specific demographics to develop guidelines for best practices moving forward for hybrid or online courses. Our findings show that second year students (sophomores) were the most impacted of the academic standing cohorts. Sophomores reported a statistically greater change in motivation after the start of the semester and statistically lower satisfaction with their performance on assignments. Females reported statistically lower motivation and a statistically lower sense of belonging in the course and science, technology, engineering, and mathematics (STEM) fields. Black/African students reported a statistically lower motivation for remote learning than Asian/Pacific Islander and White/Caucasian students. Finally, both White/Caucasian and Black/African students reported a statistically lower sense of belonging in the course and in STEM fields than Asian/Pacific islander students. Finally, statistical differences were not observed based upon first-generation status. The research indicates that students were differentially impacted by the shift to remote learning. From these findings, a stronger understanding of how specific demographics are differentially impacted by remote learning in STEM courses is provided, granting greater insight into best practices moving forward.
Application of osmotic dehydration and microwave drying to strawberries coated with edible films

Abstract Osmotic dehydration (OD) is one of the conventional methods to increase the shelf-life of vegetables and fruits. However, the operating conditions can adversely affect the organoleptic and nutritional quality of fresh products due to the high sugar uptake during processing and the loss of water-soluble constituents to the osmotic medium. The application of edible films has attracted interest due to their ability to reduce the entry of solutes and simultaneously increase the removal of water during OD treatments. Microwave (MW) is one of the most effective emerging technologies to accelerate dehydration processes in vegetable matrices. This aspect is particularly relevant in strawberries, given its high content in bioactive and nutritional compounds. Thus, the aim of this paper was to assess the influence of edible film application (alginate–lactate) in strawberry slabs during combined OD-microwaves dehydration processes. Samples of 1 cm thickness were treated with sucrose solution (60°Bx, 40 °C, 4 h) and then were dehydrated in a microwave oven (1.2 W/g). The application of alginate–lactate edible films resulted in similar weight and water losses but lower solids gain compared to uncoated samples during OD treatment. OD pre-treated MW-dried strawberry slabs with moisture contents up to 0.15 kg dry basis were obtained after 100 min of MW drying. Besides, the effective diffusional coefficient (De) was estimated for MW drying process, values ranged from 4.5 to 8.8 10−10 m2/s when shrinkage effect was considered, and from 1.1 to 2.3 10−9 m2/s for constant thickness assumption.
Effects of solar park construction and solar panels on soil quality, microclimate, CO2 effluxes, and vegetation under a Mediterranean climate

Solar energy is increasingly used to produce electricity in Europe, but the environmental impact of constructing and running solar parks (SP) is not yet well studied. Solar park construction requires partial vegetation removal and soil leveling. Additionally, solar panels may alter soil microclimate and functioning. In our study of three French Mediterranean solar parks, we analyzed:(1) effects of solar park construction on soil quality by comparing solar park soils with those of semi‐natural land cover types (pinewood and shrubland) and abandoned croplands (former vineyards); and (2) the effect of solar panels on soil microclimate, CO2 effluxes, and vegetation. We measured 21 soil properties of physical, chemical, and microbiological soil quality in one solar park and its surroundings to calculate integrated indicators of soil quality. We surveyed soil temperature and moisture, CO2 effluxes, and vegetation below and outside solar panels of three solar parks. Soil aggregate stability was reduced by SP construction resulting in a degradation of soil physical quality. Soil chemical quality and a general indicator of soil quality were lower in anthropogenic (SP and abandoned vineyards) than in semi‐natural (pinewood and shrubland) land cover types. However, differences between abandoned vineyards representing the preconstruction land cover type and solar parks were not significant. Solar panels reduced the soil temperature by 10% and soil CO2 effluxes by 50% but did not affect early successional plant communities. Long‐term monitoring is needed to evaluate the effects of solar panels on vegetation.
Ultrafast Ultrasound-Derived Muscle Strain Measure Correlates with Carotid Local Pulse Wave Velocity in Habitual Resistance-Trained Individuals

Purpose: this study investigated the effects of the intensity of machine-based bicep curl resistance exercise on ultrafast ultrasound-derived muscle strain rate and carotid ultrafast pulse wave velocity (ufPWV), and examined the association between muscle strain rate, ufPWV, and established carotid function measures in habitual resistance-trained individuals. Methods: twenty-three young habitual resistance-trained males (age: 24 ± 1 year, body mass index = 24 ± 1 kg/m2) were recruited to participate in two bouts of acute bicep curl exercise. After one-repetition maximum determination (1RM), the participants were randomly assigned to engage in bicep curls at 40 or 80%1RM intensity (10 reps × five sets) by a crossover study design. The muscle strain rate of bicep muscle, carotid ufPWV during systole(ufPWV-sys), and diastole (ufPWV-dia) were obtained pre- and post-exercise. In addition, carotid function measures were calculated by obtained carotid diameter and central blood pressure changes. Results: compared with pre-exercise, the reduction in post-exercise muscle strain rate and its area under the curve of 80%1RM was greater than those of 40%1RM. Both ufPWV-sys and ufPWV-dia increased regardless of exercise intensity. Baseline bicep muscle strain rate correlated not only with ufPWV-sys (r = −0.71, p = 0.001), ufPWV-dia (r = −0.74, p = 0.001), but also carotid compliance (r = 0.49, p = 0.02), distensibility (r = 0.54, p = 0.01) and ß stiffness (r= −0.84, p < 0.0001). The ufPWVs also correlated with ß stiffness (r = 0.64–0.76, p = 0.01). Conclusion: muscle stiffness measured by ultrafast ultrasound elastography increases positively with resistance exercise intensity, and it appears to correlate with carotid ufPWV and established carotid function measures in habitual resistance-trained individuals.
Preparation of Readily-to-Use Stilbenoids Extract from Morus alba Callus Using a Natural Deep Eutectic Solvent

The consumer and cosmetic industries have recently placed a greater emphasis on ecofriendly solvents for botanical extraction, including natural deep eutectic solvents (NADES). In this study, NADES were prepared for Morus alba callus extraction. The efficiency of extraction from the NADES and methanol was investigated by comparison of the stilbenoids yield and anti-melanogenesis activity. Prior to testing the irritability of a suitable NADES on the reconstructed human epidermis (RhE), the effect of the selected NADES on stilbenoids stability was determined. The results showed that the highest yields of stilbenoids were obtained from choline chloride-glycerol mixtures (Ch1G2) and methanol extracts, with no significant difference in yields (5.06 ± 0.05 and 6.32 ± 0.40 mg/g callus dry weight, respectively). The NADES extracts of M. alba callus showed comparable anti-melanogenesis activity compared to methanol. In term of stability, stilbenoids in Ch1G2 remained stable after six months of storage at 4 °C except resveratrol. Furthermore, Ch1G2 had no irritation effect on RhE. Thus, based on the findings of this study, Ch1G2 is an intriguing green solvent alternative for the extraction of M. alba callus and may be advantageous for the preparation of skin-lightening cosmetics.
Compaction, mechanical strength and disintegration of palm oil empty fruit bunch (EFB) carboxymethyl cellulose (CMC) tablets

In this work, the compaction, tablet mechanical strength and tablet disintegration characteristics of carboxymethyl cellulose (CMC) derived from palm oil empty fruit bunches (EFB) were studied. These characteristics were then compared with an established tablet binder, microcrystalline cellulose (MCC). Tablets with 13-mm diameter were formed at various compaction pressures of 37.7MPa, 75.4MPa, 113.0MPa, 150.7MPa, and 188.4MPa using a laboratory universal testing machine inside a rigid die set. The results showed that increasing the compaction pressure increased the tablet elastic energy, plastic energy, mechanical strength and disintegration time in the experimental range adopted in this work. However, CMC tablets exhibited lower plastic work as well as lower mechanical strength and longer disintegration time compared to MCC tablets. In conclusion, the CMC tablet displayed lower performances in comparison to the more established tablet binder MCC as evaluated in this study.
Fish sausages prepared with inclusion of Nile tilapia minced: Correlation between nutritional, chemical, and physical properties

The aim of the study was to develop fish sausages and to identify the nutritional and technological effects of the increasing inclusion of minced fish (MF) derived from wastes of Nile tilapia processing. The sausages showed an increasing decrease in moisture and protein content, with consequent increase in fat, ash, and mineral content with inclusion from zero to 100% MF. The formulations had a good fatty acid profile and stood out because they did not have trans fat. The product showed higher red color intensity and higher red color intensity and adhesiveness indice, and lower hardness and chewiness indices as the inclusion of MF increased. Through Pearson's correlation coefficients, all the studied variables showed positive or negative correlation, confirming the influence of the MF addition on the developed sausages and evidencing the interaction importance of the components in the final product quality. The sausage developed with 50% MF was considered the ideal formulation. PRACTICAL APPLICATIONS: In a scenario of constant competitiveness in the food sector, the development of new products focusing on the use of agroindustrial waste is closely related to current consumer trends. Fish is an excellent source of animal protein with a wide range of essential nutrients; therefore, there is a growing interest in the manufacture of innovative fish products that ensure mainly the use of minced fish, making possible the sustainable management of fish agribusiness. This study complies with the commitment of environmental protection due to the reduction, to practically zero, of the fish processing wastes.