Miracle-dz/UniFAR-FTUs huggingface dataset:
A three-sample study of perfectionism and field test performance in athletes

Abstract Field tests are commonly used by sport scientists for performance monitoring and evaluation. While perfectionism predicts performance in a range of contexts, it is currently unclear whether perfectionism predicts performance in such tests. To address this lack of understanding, the present study examined the relationships between perfectionism and fitness-based field test performance across three athlete samples. After completing a measure of perfectionism (striving for perfection and negative reactions to imperfection), sample one (n = 129 student athletes) participated in a series of countermovement jumps and 20-metre sprint trials, sample two (n = 136 student athletes) participated in an agility task, and sample three (n = 116 junior athletes) participated in the Yo-Yo intermittent recovery test (level one). Striving for perfection predicted better sprint and Yo-Yo test performance. Negative reactions to imperfection predicted worse sprint performance. Mini meta-analyses of the combined data (N = 381) showed that striving for perfection was positively related to performance (r+ = .24), but negative reactions to imperfection was unrelated to performance (r+ = –.05). The present findings indicate that striving for perfection may predict better fitness-based field test performance, while negative reactions to imperfection appears to be ambiguous.
Fructose Malabsorption in Chilean Children Undergoing Fructose Breath Test at a Tertiary Hospital

ABSTRACT Fructose is a highly abundant carbohydrate in western diet and may induce bowel symptoms in children as in adults. The main objective of this study is to describe the frequency of fructose malabsorption (FM) in symptomatic patients 18 years or younger undergoing fructose breath test in a single tertiary center between 2013 and 2018, and to evaluate whether certain symptoms are related to positivity of the test. Out of 273 tests 183 (67%) were compatible with FM. The most frequent pretest symptom in the overall study population was bloating (83%), followed by abdominal pain (73%). Patients with positive test were younger than those with a negative test (median 5 vs 8 years, P < 0.001). In multivariate analysis, which included age, sex, and symptoms (diarrhea, abdominal pain, bloating, nausea), only age <6 years (odds ratio 2.93, 95% confidence interval 1.64–5.23) and absence of nausea (odds ratio = 3.32, 95% confidence interval 1.56–7.05) were associated with FM.
Mass spectrometry reveals distinct proteomic profiles in high- and low-quality stallion spermatozoa.

The horse breeding industry relies upon optimal stallion fertility. Conventional sperm assessments provide limited information regarding ejaculate quality and are not individually predictive of fertilising potential. The aim of this study was to harness mass spectrometry to compare the proteomic profiles of high- and low-quality stallion spermatozoa, with the ultimate goal of identifying fertility biomarker candidates. Extended stallion semen (n=12) was fractionated using Percoll density gradients to isolate low-quality and high-quality sperm populations. Motility and morphological assessments were carried out, and proteomic analyses was conducted using UHPLC-MS/MS. High-quality spermatozoa recorded higher total (95.2±0.52% vs 70.6±4.20%; P≤0.001) and progressive motilities (43.4±3.42% vs 27.3±4.32%; P≤0.05), and a higher proportion of morphologically normal cells (50.2±4.34% vs 38.8±2.72%; P≤0.05). 1,069 proteins were quantified by UHPLC-MS/MS, of which 22 proteins were significantly more abundant in the high-quality sperm population (P≤0.05). A-kinase anchor protein 4 (AKAP4) and Hexokinase 1 (HK1) were considered possible biomarker candidates and their differential expression was confirmed by immunoblot. Protein expression was significantly correlated with total (AKAP4 R2=0.38, P≤0.01; HK1 R2=0.46, P≤0.001) and progressive motilities (AKAP4 R2=0.51, P≤0.001; HK1 R2=0.55, P≤0.01), percentage rapid (AKAP4 R2=0.29, P≤0.05; HK1 R2=0.58, P≤0.001), straight line velocity (HK1 R2=0.50, P≤0.01) and straightness (HK1 R2=0.40, P≤0.01). Furthermore, AKAP4 was highly susceptible to adduction by 4-hydroxynonenal (4HNE), which resulted in a global reduction in the phosphorylation profiles following capacitation. In conclusion, the proteomic profiles of high- and low-quality stallion spermatozoa differ substantially, and proteins such as AKAP4 and HK1 could serve as biomarkers of ejaculate quality.
CRNDE mediates the viability and epithelial–mesenchymal transition of renal cell carcinoma via miR-136-5p

Abstract Long non-coding RNAs (lncRNAs) regulate epithelial–mesenchymal transition (EMT) and the mutual adhesion and development of renal cell carcinoma (RCC). The underlying molecular mechanism of EMT and RCC cells in the treatment of RCC was less reported. In this study, the related functional lncRNA and miRNA in RCC tissues were predicted by bioinformatics analysis and verified by quantitative real-time PCR (qRT-PCR). The RNA interference technology was applied to measure the effects of the predicted lncRNAs and miRNAs on RCC cells. The expressions of EMT-related mRNAs and proteins were determined using qRT-PCR and Western-blot experiments. CRNDE was overexpressed and miR-136-5p was low-expressed in RCC. Upregulation of CRNDE could promote the viability, migration, invasion of RCC, while downregulation of CRNDE produced the opposite effects. Both the upregulation and downregulation of CRNDE alternated the protein expressions related to EMT, while miR-136-5p resulted in the opposite effects on CRNDE. Moreover, the promotive effect of overexpressed CRNDE on RCC cells could be blocked by miR-136-5p mimic. CRNDE can mediate miR-136-5p, promote the development of EMT and RCC cells, showing the potential to serve as a novel biomarker and therapeutic target in RCC treatment.
UTILIZATION OF ADULT BURROWS BY JUVENILES OF THE GHOST SHRIMP, CALLIANASSA JAPONICA ORTMANN : EVIDENCE FROM RESIN CASTS OF BURROWS

: Polyester resin casts of burrows of the thalassinidean ghost shrimp ， Callianassa japonica ORTMANN ， were collected on an intertidal sand flat in west Kyushu ， Japan. One burrow cast obtained in. September 1989 and another ， obtained in September 1990 ， had a thin “ branch" originating from the stout adult burrow cas t. Evidence pointed to such branches being inhabited by newly recruited individuals of C. japonica. It is believed that settling larvae and/or newly settled juveniles had entered the surface openings of the adult burrows to later branch off independently.
Differential Expression of Multiple Disease-Related Protein Groups Induced by Valproic Acid in Human SH-SY5Y Neuroblastoma Cells

Valproic acid (VPA) is a multifunctional medication used for the treatment of epilepsy, mania associated with bipolar disorder, and migraine. The pharmacological effects of VPA involve a variety of neurotransmitter and cell signaling systems, but the molecular mechanisms underlying its clinical efficacy is to date largely unknown. In this study, we used the isobaric tags for relative and absolute quantitation shotgun proteomic analysis to screen differentially expressed proteins in VPA-treated SH-SY5Y cells. We identified changes in the expression levels of multiple proteins involved in Alzheimer’s disease, Parkinson’s disease, chromatin remodeling, controlling gene expression via the vitamin D receptor, ribosome biogenesis, ubiquitin-mediated proteolysis, and the mitochondrial oxidative phosphorylation and electron transport chain. Our data indicate that VPA may modulate the differential expression of proteins involved in mitochondrial function and vitamin D receptor-mediated chromatin transcriptional regulation and proteins implicated in the pathogenesis of neurodegenerative diseases.
Carotid Lumen Diameter Is Associated With All‐Cause Mortality in the General Population

Background Common carotid intima–media thickness (cIMT) is a biomarker for subclinical atherosclerosis and is associated with all‐cause as well as cardiovascular mortality. Higher cIMT is accompanied by a compensatory increase in lumen diameter (LD) of the common carotid arteries. Whether cIMT or LD carry more information with regard to mortality is unclear. Methods and Results A total of 2751 subjects (median age 53 years; 52% female) were included. During a median follow‐up of 14.9 years (range: 12.8–16.5) a total of 506 subjects died. At baseline, cIMT and LD were assessed by carotid ultrasound scans. Multivariable Cox regression models were used to relate cIMT, LD, LD adjusted for cIMT (LD+cIMT), and LD/cIMT ratio with all‐cause, cardiovascular, and noncardiovascular mortality. All models were ranked using Akaike's information criterion. Harrel's c statistic was used to compare the models' predictive power for mortality. A 1‐mm increase in LD was related to a higher risk for all‐cause mortality (hazard ratio [HR], 1.29; 95% CI, 1.14–1.45, P<0.01). This association remained significant when cIMT was added to the model (HR, 1.26; 95% CI, 1.11–1.42; P<0.01). A 1‐mm higher cIMT was also related with greater mortality risk (HR, 1.73; 95% CI, 1.09–2.75). The LD/cIMT ratio was not associated with all‐cause mortality. LD had the lowest Akaike's information criterion regarding all‐cause mortality and improved all‐cause mortality prediction compared with the null model (P=0.01). CIMT weakened all‐cause mortality prediction compared with the LD model. Conclusions LD provided more information for all‐cause mortality compared with cIMT in a large population‐based sample.
Observing Nitrogen Dioxide Air Pollution Inequality Using High-Spatial-Resolution Remote Sensing Measurements in Houston, Texas.

Houston, Texas is a major U.S. urban and industrial area where poor air quality is unevenly distributed and a disproportionate share is located in low-income, non-white, and Hispanic neighborhoods. We have traditionally lacked city-wide observations to fully describe these spatial heterogeneities in Houston and in cities globally, especially for reactive gases like nitrogen dioxide (NO2). Here, we analyze novel high-spatial-resolution (250 m × 500 m) NO2 vertical columns measured by the NASA GCAS airborne spectrometer as part of the September-2013 NASA DISCOVER-AQ mission and discuss differences in population-weighted NO2 at the census-tract level. Based on the average of 35 repeated flight circuits, we find 37 ± 6% higher NO2 for non-whites and Hispanics living in low-income tracts (LIN) compared to whites living in high-income tracts (HIW) and report NO2 disparities separately by race ethnicity (11-32%) and poverty status (15-28%). We observe substantial time-of-day and day-to-day variability in LIN-HIW NO2 differences (and in other metrics) driven by the greater prevalence of NOx (≡NO + NO2) emission sources in low-income, non-white, and Hispanic neighborhoods. We evaluate measurements from the recently launched satellite sensor TROPOMI (3.5 km × 7 km at nadir), averaged to 0.01° × 0.01° using physics-based oversampling, and demonstrate that TROPOMI resolves similar relative, but not absolute, tract-level differences compared to GCAS. We utilize the high-resolution FIVE and NEI NOx inventories, plus one year of TROPOMI weekday-weekend variability, to attribute tract-level NO2 disparities to industrial sources and heavy-duty diesel trucking. We show that GCAS and TROPOMI spatial patterns correspond to the surface patterns measured using aircraft profiling and surface monitors. We discuss opportunities for satellite remote sensing to inform decision making in cities generally.
A Survey of Ticks Infesting Dogs and Cats in Ireland

Simple Summary Ticks are important ectoparasites of companion animals not only causing localised skin damage, but are also vectors for a variety of pathogens. Veterinarians submitted ticks found on dogs and cats during routine examination for identification and completed a short questionnaire. A total of 120 ticks were submitted and we found that Ixodes ricinus, the sheep/castor bean tick, was the most abundant species on dogs while Ixodes hexagonus, the hedgehog tick, was the most abundant species on cats. Although most veterinary practitioners indicated that ticks were a concern to their clients, at the same time neither vets nor their clients were particularly concerned about tick-borne diseases in their animals. Interviews of dog walkers in the greater Dublin area indicate that pet owners are well aware of the presence of ticks in their surroundings. The loss of efficacy of some ectoparasiticides flagged by many pet owners requires further investigation. Abstract Ticks are important ectoparasites of dogs and cats. Infestations can result in itching and localised dermatitis. In addition, ticks can act as vector of a range of viral, bacterial and protozoal pathogens. This paper reports the results of a nationwide survey of ticks infesting dogs and cats in Ireland. Seventy veterinary practices submitted a total of 120 ticks collected from 56 dogs and 16 cats. Ixodes ricinus was the most abundant species on dogs while Ixodes hexagonus was the most abundant species on cats. The remainder were identified as Ixodes canisuga and a single Rhipicephalus sanguineus specimen. The garden was most frequently associated with tick exposure in both dogs and cats. Sporting dog breeds (n = 17; 31%) were more likely to be infested with ticks than any other breed. Nearly all (n = 56; 95%) veterinarians indicated that ticks are a concern to their clients when they are found on their pets. Pet owners used a variety of products to control ectoparasites on their animals but a significant number (n = 18, 31%) indicated that they felt that the products are less effective highlighting the need for further investigations. Field sampling indicated that ticks are present at a low level in much of the greater Dublin area.
A Toolbox of Surgical Techniques for Palatal Fistula Repair

Objective: To provide an inventory of oronasal fistula repair techniques alongside expert commentary on which techniques are appropriate for each fistula type. Design: A 4-stage approach was used to develop a consensus on surgical techniques available for fistula repair: (1) in-person discussion of oronasal fistula cases among cleft surgeons, (2) development of a schema for fistula management using transcripts of the in-person case discussion, (3) evaluation of the preliminary schema via a web-based survey of additional cleft surgeons, and (4) revision of the management schema using survey responses. Participants: Six cleft surgeons participated in the in-person case discussion. Eleven additional surgeons participated in the web-based survey. Participants had diverse training experiences, having completed residency and fellowship at 20 different hospitals. Results: A schema for fistula management was developed, organized by fistula location. The schema catalogues all viable approaches for each location. For fistulae involving the soft palate, the schema stresses the importance of evaluating for velopharyngeal insufficiency (VPI) and incorporating VPI management into fistula repair. For fistulae involving the hard palate, the schema separately enumerates the techniques available for nasal lining repair and for oral lining repair in each region. The schema also catalogues the diversity of approaches to lingual- and labioalveolar fistula, including variation in timing, orthodontic preparation, and simultaneous alveolar bone grafting. Conclusions: This study employed consensus methods to create a comprehensive inventory of available fistula repair techniques and to identify preferential techniques among a diverse group of surgeons.
The source of the Canary Current in fall 2009

[1] The source of the Canary Current has been inferred from an inverse box model applied to the hydrographic data of a survey carried out in 2009 in the northeast subtropical gyre (29–37°N, 9–24°W). The Portugal Current is observed between 13.5 and 14.8°W at 37°N carrying 1.8±0.4 Sv southward. This current presumably merges with the eastward transport of the Azores Current System and partly contributes to the Mediterranean inflow and partly to the northward recirculation of the Azores Current through the Gulf of Cadiz. The Azores Current System is located in the meridional range 33.50–36.25°N at 24.50°W. This System transports eastward 7.2±0.5 Sv in the thermocline layers and 1.1±0.8 Sv at intermediate layers. The Azores Current intermediate water mass has the highest portion of Sub-Arctic intermediate water (SAIW) in the region, while the Azores Countercurrent intermediate waters mass is mainly Mediterranean water. The Canary Current extends from 22.25° to 18.50°W at 29°N, the westernmost position ever observed. This current transports southward −6.2±0.6 Sv in the thermocline layers and −2.0±0.8 Sv in the intermediate layers. This intermediate flow shows a relative maximum of oxygen and a relative minimum in nutrient concentration, indicating the presence of SAIW. The study concludes that, at least in fall 2009, the Canary Current extends to the intermediate waters ( γn≤27.9220 approximately 1600 dbar) and that Azores Current feeds the Canary Current at surface and intermediate layers.
Vascular Function Is Differentially Altered by Distance after Prolonged Running

ABSTRACT Purpose Ultraendurance exercise is steadily growing in popularity; however, the effect of increasingly prolonged durations of exercise on the vascular endothelium is unknown. The aim of this study was to characterize the effect of various ultramarathon running distances on vascular form and function. Methods We evaluated vascular endothelial function via flow-mediated dilation (FMD) in the superficial femoral artery, as well as microvascular function, inflammatory factors, and central artery stiffness, before and after participants completed 25-km (7M:2F), 50-km (11M:10F), 80-km (9M:4F), or 160-km (9M:2F) trail races all run on the same day and course. Results Completion required 149 ± 20, 386 ± 111, 704 ± 130, and 1470 ± 235 min, with corresponding average paces of 6.0 ± 0.8, 7.7 ± 2.2, 8.6 ± 1.3, and 9.6 ± 1.3 min·km−1, respectively. At baseline, there were no differences in participant characteristics across race distance groups. Shear rate stimulus trended toward an increase after the race (P = 0.07), but resting postrace artery diameter (P < 0.001) was elevated to a similar extent in all conditions. There was a reduction in FMD after the 50-km race (Δ −1.9% ± 2.2%, P < 0.01), but not the 25-km (Δ +0.3% ± 2.9%, P = 0.8), the 80-km (Δ −1.5% ± 3.2%, P = 0.1), or the 160-km (Δ +0.5% ± 2.5%, P = 0.5) race. Inflammatory markers increased most after 160 km, but arterial stiffness and microvascular function were not differently affected by race distance. Conclusions Although the superficial femoral artery baseline diameter was larger postexercise regardless of race distance, only the 50-km race reduced FMD, whereas a short-duration higher-intensity race (25 km) and longer-duration lower-intensity races (160 km) did not. Therefore, a 50-km ultramarathon may represent the intersection between higher-intensity exercise over a prolonged duration, causing reduced endothelial function not seen in shorter or longer distances.
Aspergillus flavus — primary causative agent of aflatoxins in dried figs

Aspergillus sect. Flavi isolates from Turkish dried figs have been determined using PCR amplification of the ITS1 and ITS2 rDNA regions. Species were identified by comparing partial 18S rDNA sequences from 57 different fungal isolates comprising 5 A. parasiticus strains, 1 A. tamarii strain, and 51 A. flavus strains with known ribosomal sequences using BLAST search. Sequence comparisons between the isolates and reference cultures showed a 95-99% similarity; morphological and phenotypical character comparisons of the same strains produced equally close similarities. The sole exception was an aflatoxin B1 and B2 producing strain that cannot produce cyclopiazonic acid; this strain, originally identified as A. flavus, was instead found to represent A. parasiticus.
Genetically Determined Levels of Serum Metabolites and Risk of Neuroticism: A Mendelian Randomization Study

Abstract Background Neuroticism is a strong predictor for a variety of social and behavioral outcomes, but the etiology is still unknown. Our study aims to provide a comprehensive investigation of causal effects of serum metabolome phenotypes on risk of neuroticism using Mendelian randomization (MR) approaches. Methods Genetic associations with 486 metabolic traits were utilized as exposures, and data from a large genome-wide association study of neuroticism were selected as outcome. For MR analysis, we used the standard inverse-variance weighted (IVW) method for primary MR analysis and 3 additional MR methods (MR-Egger, weighted median, and MR pleiotropy residual sum and outlier) for sensitivity analyses. Results Our study identified 31 metabolites that might have causal effects on neuroticism. Of the 31 metabolites, uric acid and paraxanthine showed robustly significant association with neuroticism in all MR methods. Using single nucleotide polymorphisms as instrumental variables, a 1-SD increase in uric acid was associated with approximately 30% lower risk of neuroticism (OR: 0.77; 95% CI: 0.62–0.95; PIVW = 0.0145), whereas a 1-SD increase in paraxanthine was associated with a 7% higher risk of neuroticism (OR: 1.07; 95% CI: 1.01–1.12; PIVW = .0145). Discussion Our study suggested an increased level of uric acid was associated with lower risk of neuroticism, whereas paraxanthine showed the contrary effect. Our study provided novel insight by combining metabolomics with genomics to help understand the pathogenesis of neuroticism.