Miracle-dz/UniFAR-FTUs huggingface dataset:
Alcohol Use Motives and Cannabis Use among Young Adults: Between- and Within-Person Associations Based on Monthly Data from a Community Sample

Abstract Objective: Alcohol use motives may characterize types of drinking that have unique associations with cannabis use and illuminate psychological processes underlying cannabis use. This study examined how alcohol use motives, both on average across two years and in a particular month, were associated with any and frequent cannabis use. Method: A young adult community sample (n = 486; 54% female, age 18–23 at enrollment) who used alcohol and cannabis in the year prior to study enrollment provided two years of monthly data. Multilevel logistic regression models predicting any and frequent (10+ occasions) past-month cannabis use estimated both between- and within-person effects of alcohol use motives, controlling for frequency of alcohol use and demographic covariates. Results: Alcohol use frequency was positively associated with any cannabis use at the between- and within-person levels and frequent cannabis use at the within-person level. Across two years, individuals who had higher average coping drinking motives and lower average social and conformity drinking motives were more likely to use cannabis frequently. Further, between-person variation in social motives was negatively associated with any cannabis use. Within-person, months with greater enhancement and social motives were associated with higher probability of any cannabis use. Conclusions: Using alcohol for coping reasons, rather than other-focused social reasons, indicated greater risk for frequent cannabis use, although drinking for social and enhancement reasons in a particular month signaled slightly increased short-term probability of any cannabis use. Assessment of alcohol motives may help guide targeting and timing of prevention related to cannabis use.
Discussing the unspoken: A qualitative analysis of online forum discussions on mental health problems in young Moroccan-Dutch migrants

Migrants and their offspring are at increased risk of developing mental disorders. Previous research has shown associations between adverse social factors (e.g., discrimination, lack of social support) and mental health problems in migrants, but it is unknown how these associations are understood by migrants themselves. In this study, we aimed to gain explorative insight into the way young Moroccan-Dutch people experience their social environment, and how they relate this social environment to the development of mental health problems. At www.marokko.nl, the largest online discussion platform for young Moroccan-Dutch people, contributors discuss a broad variety of subjects, including societal, cultural, religious, and mental health issues. Combining deductive and inductive approaches to qualitative data analysis, we analysed 22 forum discussions at marokko.nl about mental health problems, after which data saturation was reached. Contributors described feeling isolated and experiencing discrimination in their social environment. Contributor comments identified social challenges arising from Dutch society, Dutch culture (e.g., being too individualistic), Moroccan culture (e.g., strict parenting style), and living between these two cultures. These social challenges are perceived to be associated with mental health problems. Furthermore, we created a model describing the different types of explanations contributors used for mental health problems, being: religious (e.g., possession); medical (i.e., a bio-psycho-social cause); or a combination of both. This model can help clinicians in delivering culturally sensitive mental health care. Lastly, this study shows the taboo on mental health problems in the Moroccan-Dutch population and the opportunity to open up in the online environment.
Modified binary randomized response technique models

Social Desirability Bias (SDB) is the tendency in respondents to answer questions untruthfully in the hope of giving good impression to others. SDB occurs when the survey question is highly sensitive or personal, and responses cause sample statistics to systematically overestimate or underestimate corresponding population parameters. The Randomized Response Technique (RRT) is one of several methods to get around SDB in surveys involving sensitive questions in a face-to-face interview. We first review some of the well-established binary response RRT models including the two-parameter models such as the two-stage RRT model and the optional RRT model. Then, we examine an optional RRT model based on the unrelated question RRT as presented by Gupta, Tuck, Spears Gill, and Crowe (2013). Also, we show another optional RRT model based on the two-stage RRT. Next, we carry out efficiency comparisons between these models and show simulation results. While these two models are all based on the split-sample approach to estimate two unknown parameters of interest ( $\pi$ and $\omega$—the prevalence of sensitive characteristic and the sensitivity level of the underlying question respectively), the next two models utilize the two-question approach instead. One of them relies on the unrelated question RRT model. And the other relies on the two-stage optional RRT model. Again, efficiencies of estimators are compared and simulation results are provided. In the end, simulation results and figures are presented and some conclusions are made regarding which estimator performs better. It turns out that the two-stage optional indirect RRT model with two-question approach performs better than other binary optional RRT models.
Monitoring Pulse Rate in the Background Using Front Facing Cameras of Mobile Devices

We propose a novel framework to passively monitor pulse rate during the time spent by users on their personal mobile devices. Our framework is based on passively capturing the user's pulse signal using the front-facing camera. Signal capture is performed in the background, while the user is interacting with the device as he/she normally would, e.g., watch movies, read emails, text, and play games. The framework does not require subject participation with the monitoring procedure, thereby addressing the well-known problem of low adherence with such procedures. We investigate various techniques to suppress the impact of spontaneous user motion and fluctuations in ambient light conditions expected in non-participatory environments. Techniques include traditional signal processing, machine learning classifiers, and deep learning methods. Our performance evaluation is based on a clinical study encompassing 113 patients with a history of atrial fibrillation (Afib) who are passively monitored at home using a tablet for a period of two weeks. Our results show that the proposed framework accurately monitors pulse rate, thereby providing a gateway for long-term monitoring without relying on subject participation or the use of a dedicated wearable device.
Opposite effects of rofecoxib on NF- κ B and AP-1 activation 1

Rofecoxib is a selective cyclooxygenase-2 (COX-2) inhibitor approved for the treatment of pain and inflammation in rheumatoid- and osteoarthritis. Daily doses between 12.5 and 50 mg were found to reduce pain and inflammation, however without a clear dose effect relationship. Interestingly, rofecoxib treatment is associated with an unexpected incidence of renal adverse events as compared to other COX-inhibitors. Here, the effects of rofecoxib on the transcription factors NF- κ B and AP-1 were analysed to find out whether transcriptional changes might explain the lack of clear dose dependency and the occurrence of renal side effects. In vitro, rofecoxib dose-dependently inhibited DNA binding capacity of NF- κ B at doses of 10-100 µM whereas the binding activity of AP-1 was considerably increased at 100 µM. In vivo, the anti-inflammatory effect of rofecoxib was equal at 1 and 10 mg/kg whereas 50 mg/kg caused a significant further reduction of a zymosan induced paw edema. This was associated with a clear decrease of iNOS protein expression in the spinal cord at this dose. At 1 and 10 mg/kg however, iNOS was increased but COX-2 was decreased. Thus, the expression of pro-inflammatory proteins was similarly inconsistent as transcription factor regulation. In conclusion the opposite effects of rofecoxib on AP-1 and NF- κ B may explain the lack of clear dose dependency with rofecoxib in clinical studies or animal experiments. The effects on AP-1 may possibly affect renal sodium transport since certain renal sodium channels are regulated through AP-1. Transcription factor regulation might therefore influence both wanted and unwanted effects of rofecoxib.
University of Birmingham The heterogeneity of spouse abuse: A review

Recent research suggests that spouse abusers are not a homogenous group. Holtzworth-Munroe and Stuart (1994) propose three types of domestic violent men; Family Only, Generally Violent/Antisocial and Dysphoric/ Borderline Personality. This theoretical classification is compared to nine empirical research studies and two hypothetical studies, which can be found in the literature dated from 1994 onwards. The review provides support for the three-fold typology. The total averages of offenders classified by Holtzworth-Munroe and Stuarts (1994) typology across the studies were 50%, 30% and 20% respectively. However, when sample type was considered a significant difference between court referrals and volunteers was found for the men’s distribution across the three types, with court referred men being less likely to be categorised into the Family Only group. All research to date is criticised for its narrow focus on the offender and its lack of a scientific profiling approach. Other factors such as the context, triggers for violence and the behavioural actions of the victim need to be considered. A more holistic family focused typology is suggested to be more appropriate for those victims who do not want to separate from their violent spouse.
Late Infective Endocarditis After Transcatheter Mitral Valve Reconstruction (MitraClip): A Case Report and a Review of the Literature

Percutaneous transcatheter mitral valve reconstruction in edge to edge fashion is a well-established option in inoperable or high peri-operative risk patients with severe, symptomatic mitral valve regurgitation. MitraClip in combination with medical treatment improves survival and reduces hospitalization rates compared with optimal medical therapy alone in well selected patients. Clip-associated endocarditis is a rare complication with only few reported cases in the literature. We present a case of late infective endocarditis post Mitral Clip implantation and also review the literature regarding this new rare condition.
A brain atlas of the carrion crow (Corvus corone)

Corvidae, passerine songbirds such as jays, crows, and ravens known as corvids, have become model systems for the study of avian cognition. The superior cognitive capabilities of corvids mainly emerge from a disproportionally large telencephalon found in these species. However, a systematic mapping of the neuroanatomy of the corvid brain, and the telencephalon in particular, is lacking so far. Here, we present a brain atlas of the carrion crow, Corvus corone, with special emphasis on the telencephalic pallium. We applied four staining techniques to brain slices (Nissl, myelin, combination of Nissl and myelin, and tyrosine hydroxylase targeting catecholaminergic neurons). This allowed us to identify brain nuclei throughout the brain and delineate the known pallial subdivisions termed hyperpallium, entopallium, mesopallium, nidopallium, arcopallium, and hippocampal complex. The extent of these subdivisions and brain nuclei are described according to stereotaxic coordinates. In addition, 3D depictions of pallial regions were reconstructed from these slices. While the overall organization of the carrion crow's brain matches other songbird brains, the relative proportions and expansions of associative pallial areas differ considerably in agreement with enhanced cognitive skills found in corvids. The presented global organization of the crow brain in stereotaxic coordinates will help to guide future neurobiological studies in corvids.
Investigating the therapeutic options for diabetes‐associated male infertility as illustrated in animal experimental models

Diabetes is a rising global health concern and an increasingly common cause of male infertility. Although the definitive pathophysiological mechanisms underpinning the association between diabetes and infertility is unclear, there are several animal studies showing diabetes to be a detrimental factor on reproductive health through apoptosis, oxidative stress and impairment of steroidogenesis. Furthermore, as reflected in animal models, antidiabetic strategies and relevant treatments are beneficial in the management of infertile men with diabetes as the recovery of euglycemic status affects positively the spermatogenesis. However, the available data are still evolving and specific conclusion in human populations are not possible yet. In this review, we are discussing the current literature concerning the association of diabetes and male infertility, focusing on the therapeutic approach as illustrated in animals' models.
Photovoice and Instagram as Strategies for Youth Engagement in Disaster Risk Reduction

Community involvement is essential for an all-of-society approach to disaster risk reduction. This requires innovative consultation methods, particularly with youth and during pandemic restrictions. This article outlines methods used for a Photovoice project where we brought together student co-researchers from multiple levels (high school, undergraduate, and graduate health sciences) to explore the topic of youth engagement in disaster risk reduction. Over a two-year period, our team used Photovoice as an arts-based participatory method to collaborate with members of our EnRiCH Youth Research Team. We adapted the protocol to continue our project during the COVID-19 pandemic and presented our work in a Photovoice exhibition using Instagram. This article was written from the perspectives of high school and university students on the project. Our hybrid Photovoice protocol facilitated participation through the pandemic, including a virtual presentation at an international conference and online consultation with the Canadian Red Cross.
Evaluation of autoantibody signatures in pituitary adenoma patients using human proteome arrays

To identify the specific diagnostic biomarkers related to pituitary adenomas (PAs), we performed serological antibody profiles for three types of PAs, namely Acromegaly, Cushing's and Nonfunctional Pituitary Adenomas (NFPAs), using the human proteome (HuProt) microarray. This is the first study describing the serum autoantibody profile of PAs.
Facial Nerve Paralysis and COVID‐19: A Systematic Review

Several cases of facial nerve paralysis (FNP) post‐COVID‐19 infection have been reported with varying presentations and management. This study aims to identify FNP clinical characteristics and recovery outcomes among patients acutely infected with COVID‐19. We hypothesize that FNP is a potentially unique sequalae associated with COVID‐19 infections.
Assessing functioning for individuals with neurodevelopmental conditions: Current clinical practice in Australia

Abstract Background In the disability sector globally, and specifically in Australia, assessments of functioning have become key to diagnostic processes, and accessing therapy and funding. Over half of all individuals accessing support through Australia's National Disability Insurance Scheme have a neurodevelopmental condition diagnosis. Little is known about assessments of functioning for this population. Methods A mixed methods online survey was designed to understand the current assessment of functioning practices (including clinical contexts, concepts being assessed, and assessment methods) and barriers and facilitators to clinicians using best practice. Results were analysed descriptively, and differences between professions calculated where possible. Content analysis was used to explore qualitative comments. Results Clinicians from various medical and allied health backgrounds completed the survey (n = 93), with varying ranges of age, experience, and education. Clinicians reported that they assessed functioning across age, setting, sector, funding body, and individuals with a wide variety of diagnoses. Missing from current practice is a clear transdisciplinary conceptualisation of functioning. The largest barriers to best practice were limited time, large caseloads, availability of appropriate tools, and lack of clarity from funding bodies. Conclusions Missing from current practice is a clear transdisciplinary conceptualisation of functioning.These results will help inform steps forward to improve assessment of functioning practices to ensure that all individuals receive appropriate and sufficient support.
Safety and efficacy of the surpass streamline for intracranial aneurysms (SESSIA): A multi-center US experience pooled analysis

Background and purpose Flow diversion has established as standard treatment for intracranial aneurysms, the Surpass Streamline is the only FDA-approved braided cobalt/chromium alloy implant with 72-96 wires. We aimed to determine the safety and efficacy of the Surpass in a post-marketing large United States cohort. Materials and methods This is a retrospective multicenter study of consecutive patients treated with the Surpass for intracranial aneurysms between 2018 and 2021. Baseline demographics, comorbidities, and aneurysm characteristics were collected. Efficacy endpoint included aneurysm occlusion on radiographic follow-up. Safety endpoints were major ipsilateral ischemic stroke or treatment-related death. Results A total of 277 patients with 314 aneurysms were included. Median age was 60 years, 202 (73%) patients were females. Hypertension was the most common comorbidity in 156 (56%) patients. The most common location of the aneurysms was the anterior circulation in 89% (279/314). Mean aneurysm dome width was 5.77 ± 4.75 mm, neck width was 4.22 ± 3.83 mm, and dome/neck ratio was 1.63 ± 1.26. Small-sized aneurysms were 185 (59%). Single device was used in 94% of the patients, mean number of devices per patient was 1.06. At final follow-up, complete obliteration rate was 81% (194/239). Major stroke and death were encountered in 7 (3%) and 6 (2%) cases, respectively. Conclusion This is the largest cohort study using a 72–96 wire flow diverter. The Surpass Streamline demonstrated a favorable safety and efficacy profile, making it a valuable option for treating not only large but also wide-necked small and medium-sized intracranial aneurysms.
Aortic Arch Repair Using Open and Hybrid Techniques: A Systematic Review

Early surgical intervention is critical for treatment of aortic arch aneurysms and dissections, but limited comprehensive data exist to define the optimal approach for surgical management with respect to postoperative outcomes. We conducted a systematic review of the 2 most common surgical approaches—total arch replacement and hybrid arch repair. We referenced the electronic PubMed database reporting on outcomes for these surgical approaches from inception to June 2022. Our initial search query returned a total of 2,517 records. All records were independently screened for adherence to our inclusion criteria and a total of 12 retrospective cohort studies were identified as appropriate for inclusion. Across the included studies, a total of 618 patients underwent hybrid repair, as compared to 2,104 patients who underwent total arch replacement. We found that most of the literature supported the findings of similar rates of permanent neurologic dysfunction, acute kidney injury, and short-term mortality between approaches and higher postoperative reintervention rates following hybrid repair. Reported outcomes of studies included in this review often conflicted regarding midterm and long-term survival, as well as hospital and intensive care unit length of stay following open and hybrid repair. Future studies should address midterm and long-term survival with a prospective study design.
Long‐term effects of Pfizer‐BioNTech COVID‐19 vaccinations on platelets

There is a global concern about the safety of COVID‐19 vaccines associated with platelet function. However, their long‐term effects on overall platelet activity remain poorly understood. Here we address this problem by image‐based single‐cell profiling and temporal monitoring of circulating platelet aggregates in the blood of healthy human subjects, before and after they received multiple Pfizer‐BioNTech (BNT162b2) vaccine doses over a time span of nearly 1 year. Results show no significant or persisting platelet aggregation trends following the vaccine doses, indicating that any effects of vaccinations on platelet turnover, platelet activation, platelet aggregation, and platelet‐leukocyte interaction was insignificant.
MCU proteins dominate in vivo mitochondrial Ca2+ uptake in Arabidopsis roots

Abstract Ca2+ signaling is central to plant development and acclimation. While Ca2+-responsive proteins have been investigated intensely in plants, only a few Ca2+-permeable channels have been identified, and our understanding of how intracellular Ca2+ fluxes is facilitated remains limited. Arabidopsis thaliana homologs of the mammalian channel-forming mitochondrial calcium uniporter (MCU) protein showed Ca2+ transport activity in vitro. Yet, the evolutionary complexity of MCU proteins, as well as reports about alternative systems and unperturbed mitochondrial Ca2+ uptake in knockout lines of MCU genes, leave critical questions about the in vivo functions of the MCU protein family in plants unanswered. Here, we demonstrate that MCU proteins mediate mitochondrial Ca2+ transport in planta and that this mechanism is the major route for fast Ca2+ uptake. Guided by the subcellular localization, expression, and conservation of MCU proteins, we generated an mcu triple knockout line. Using Ca2+ imaging in living root tips and the stimulation of Ca2+ transients of different amplitudes, we demonstrated that mitochondrial Ca2+ uptake became limiting in the triple mutant. The drastic cell physiological phenotype of impaired subcellular Ca2+ transport coincided with deregulated jasmonic acid-related signaling and thigmomorphogenesis. Our findings establish MCUs as a major mitochondrial Ca2+ entry route in planta and link mitochondrial Ca2+ transport with phytohormone signaling.
PENGARUH STRUKTUR KEPEMILIKAN, UKURAN PERUSAHAAN, DAN PRAKTIK CORPORATE GOVERNANCE TERHADAP MANAJEMEN LABA

Pada suatu keadaan dimana pihak manajemen ternyata tidak berhasil mencapai target laba yang ditentukan, maka manajemen akan memanfaatkan fleksibititas yang diperbolehkan oleh standar akuntasi dalam menyusun laporan keuangan. Bertitik tolak dari penelitian di atas maka dalam penelitian ini peneliti memilih judul “Pengaruh Struktur Kepemilikan, Ukuran Perusahaan, dan Praktek Corporate Governance Terhadap Manajemen Laba (Earning Management)”. Dalam penelitian ini penulis mengambil sampel pada perusahaan manufaktur dengan periode penelitian tahun 1998-2004. Analisis data penelitian ini menggunakan regresi linier berganda. Hasil analisis menunjukkan bahwa variabel-variabel independen dalam penelitian ini, yaitu komite audit, kepemilikan keluarga dan kepemilikan institusional berpengaruh positif terhadap manajemen laba, kepemilikan manajerial, kualitas auditor dan proporsi dewan komisaris independen berpengaruh negatif terhadap manajemen laba, serta struktur kepemilikan, ukuran perusahaan dan praktik corporate governance hanya menjelaskan sebesar 0.04% terhadap praktik manajemen laba, sedangkan 99.6% dijelaskan oleh variabel yang lain. Untuk penelitian selanjutnya diharapkan menambahkan variabel-variabel lain dalam memprediksi manajemen laba seperti leverage dan likuiditas