Miracle-dz/UniFAR-FTUs huggingface dataset:
Haematological and Chosen Biochemical Parameter Assessment of the Antioxidant System in Red Deer (Cervus Elaphus) Blood in Early and Late Pregnancy

Abstract Introduction The aim of this study was to investigate changes in haematological parameters and the antioxidant system in the early and late pregnancy of red deer (Cervus elaphus). Material and Methods Blood samples were collected from 30 red deer females 50 days after impregnation and 40 days before calving. Complete blood counts and stained blood smears were assessed. Paraoxonase 1 (PON1), superoxide dismutase (SOD), catalase (CAT), glutathione reductase (GR) activities, glutathione disulphide (GSSG), total glutathione, total bilirubin, total protein, albumin, uric acid, malondialdehyde (MDA), beta-hydroxybutyrate (BHB), low-density lipoprotein (LDL), high-density lipoprotein (HDL), triglycerides, cholesterol levels and total antioxidant status (TAS) were measured. Results The haematological characteristics of blood collected in the third trimester showed higher haemoglobin levels, haematocrit, mean corpuscular volume (P < 0.05) and a lower mean cell haemoglobin concentration (P < 0.05) in comparison to samples collected on the 50th day after mating. Activity of CAT and MDA, LDL, and triglyceride levels were lower while GR, GSSG, total glutathione, total protein and BHB levels were increased in blood samples drawn in the third trimester compared with the first trimester blood samples. There were no changes in SOD, PON1 activities, TAS, bilirubin, albumin, HDL, cholesterol or uric acid concentrations. Conclusion Red deer’s compensatory mechanisms facilitate its optimal adaptation to seasonal changes evidenced by mild pronounced haematological disturbances and an effective antioxidant system during pregnancy.
Structure optimization of continuous casting tundish with channel-type induction heating using mathematical modeling

Abstract There are few studies on the shape and structure of the channel-type induction heating tundish on multi-physics field. Computational fluid dynamics has been used to study the influence of the structure of the tundish on the macroscopic transport behavior of the tundish with channel induction heating. The results show that increasing the depth of the molten pool is conducive to dynamic behavior of multiphase, the deeper the molten pool, the larger the active area, the longer residence time, the more inclusions removal and the higher ratio of plug to dead volume. Meanwhile, the larger the channel diameter, the more inclusions removal in the receiving chamber and channel. The channel induction heating has enough ability to increase the superheat and temperature compensate for the heat loss caused by the excessive residence time of the molten steel in the tundish. The change in the channel structure is crucial to the macroscopic transport behavior of the fluid. The change in channel diameter has the greatest effect on the multi-physics field in the molten pool.
Prevalence of Virulence Genes Among Escherichia Coli Strains Isolated from Food and Carcass Swabs of Different Animal Origins in Croatia

Abstract Introduction Escherichia coli is present in the normal intestinal flora but some strains can cause intestinal and extraintestinal diseases, and research on its presence in food of animal origin is in the interests of public health. This study was designed to characterise E. coli strains according to their origin, their carriage of virulence genes specific for certain pathogroups, and phylogenetic group affiliation. Material and Methods The study was carried out on 100 E. coli strains isolated from food samples of various animal origin as well as pig and cattle carcass swabs. Isolation of the strains was performed using two methods. One method included colony count and the other an overnight enrichment of the samples. Isolation was followed by DNA extraction and detection of virulence genes and phylogenetic group with conventional and multiplex PCRs. Results In this study, the most prevalent gene was EAST1 (20%) and strains which carried it were identified as enteroadherent E. coli. Other pathogroups were represented in lower incidences. Phylogenetic group analysis revealed the prevalence of the A and B1 groups, with B1 mainly present in game and cattle strains, while the majority of pig and poultry strains were assigned to group A. Conclusion This study provides an overview of the presence of potentially pathogenic strains and E. coli phylogenetic groups in Croatia, for which the data are limited. Further microbiological and molecular research is required to examine the epidemiological situation in the country.
High-pressure single-crystal synchrotron X-ray diffraction study of lillianite

Abstract In this paper, high-pressure data from a synchrotron X‑ray diffraction study on a lillianite (Pb3Bi2S6) single crystal up to ~21 GPa are presented. A phase transition from lillianite (space group Bbmm, LP lillianite) to the high-pressure form β-Pb3Bi2S6 (space group Pbnm, HP lillianite) was confirmed and bracketed between 4.90 and 4.92 GPa. The transition is reversible but of first-order with a hysteresis of ~2.8 GPa. It showed weak effects of pseudo-merohedral twinning that disappeared upon decompression, testifying to a full recovery of the single crystal of lillianite. This makes lillianite an interesting shape-memory material. With a bulk modulus K4.9 = 78(3) GPa and K′ = 5.1(4), β-Pb3Bi2S6 is markedly less compressible than lillianite [K0 = 44(2) GPa, K′ = 7(1)]. Compressional anisotropy increases markedly in β-Pb3Bi2S6 with compressibility along the b axis [M0b = 130(6) GPa and Mb′=19(3) $M_{b}^{\prime }=19(3)$in lillianite, M4.9b = 145(4) GPa ′and Mb′=16.0(7) $M_{b}^{\prime }=16.0(7)$in β-Pb3Bi2S6] significantly larger than that along the other two axes [M0a = 118′(5) GPa, Ma′=21(3), $M_{a}^{\prime }=21(3),$M0c = 139(12) GPa, and Mc′=31(10) $M_{c}^{\prime }=31(10)$in lillianite, M4.9a = 242(12) GPa, Ma′=8(1) $M_{a}^{\prime}=8(1)$, M4.9c = 242(5) GPa, and Mc′=29(1) $M_{c}^{\prime }=29(1)$in β-Pb3Bi2S6]. The behavior of lillianite at high pressure is an interesting case study in relation to non-quenchable ultrahigh-pressure phases likely occurring in the inner Earth, like post-perovskite MgSiO3, the oxide homologue N = 1 of the lillianite series. The β-Pb3Bi2S6 structure, on the other hand, is the N = 3 homologue of the meneghinite series to which the higher-pressure modification of the post-perovskite structure also belongs (homologue N = 1). This makes the two forms of Pb3Bi2S6 potential equivalents of high- and ultrahigh-pressure Mg silicates that could occur both in the deep earth and in other rocky extrasolar planetary bodies.
OP-ICVA200148 1..6

OBJECTIVES: Patients with pleural infections frequently have several comorbidities and inferior long-term survival. We hypothesized that these patients represent a vulnerable cohort with high rates of hospitalization and frequent use of healthcare services. This study aims to ascertain the need for and causes of treatment episodes after pleural infections during long-term follow-up. METHODS: Patients treated for pleural infections at Tampere University Hospital between January 2000 and December 2008 (n = 191, 81% males, median age 58 years) were included and compared to a demographically matched population-based random sample of 1910 controls. Seventy percent of the pleural infections were caused by pneumonias and 80% of the patients underwent surgery. Information regarding later in-hospital periods and emergency room and out-patient clinic visits, as well as survival data, was obtained from national registries and compared between patients and controls. RESULTS: Patients treated for pleural infections had significantly higher rates of hospitalizations (8.19 vs 2.19), in-hospital days (88.5 vs 26.6), emergency room admissions (3.18 vs 1.45), out-patient clinic visits (41.1 vs 11.8) and procedures performed (1.26 vs 0.55) per 100 TH O R A C IC VC The Author(s) 2020. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved. Interactive CardioVascular and Thoracic Surgery (2020) 1–6 ORIGINAL ARTICLE doi:10.1093/icvts/ivaa147 D ow naded rom http/academ ic.p.com /icvts/advance-art.1093/icvts/ivaa147/5903198 by gest on 20 Sptem er 2020 patient-months when compared to controls during 5-year follow-up, in addition to having increased mortality (30% vs 11%), P-value <0.00001 each. Particularly, episodes due to respiratory and digestive diseases, malignancies and mental disorders were more frequent. The patients’ comorbidities, such as alcoholism or chronic pulmonary disease, were associated with more frequent use of healthcare services. CONCLUSIONS: Patients treated for pleural infections have high rates of hospitalizations, emergency room admissions and out-patient clinic visits during follow-up.
Impaired Hand Training Device with Wireless Data Communication

— In this paper, we aim at combining assistive technology with the Internet of Things in order to create a system with an important health impact on the quality of life of people with disabilities. In this system, an impaired hand training device with real time data transactions has been designed and developed. This device allows patients to practice their hand rehabilitation routine daily at home avoiding the exhausting transportation to the clinic or the hospital. Then, it will wirelessly and automatically send the acquired data to a Web system accessed by the physician and the patient as well. Consequently, the physician will be able to view, monitor, and adjust the requested routines for each patient and communicate this information with him/her in order to achieve the best results in the shortest possible time.
Influence of using some natural materials and biological fertilizers on growth and quality of pea yield

Two field experiments were carried out during winter season of 2011 and 2012 years at the Experimental Farm of Kaha Station , Qalubia Governorate to study the influence of with some natural stimulants on pea plants c.v Master B using ascobean compound as a source for citric and ascorbic acids as well as power-mix compound as a source for amino acids and using also two natural fertilizers, i.e. rock phosphate as a source of phosphours + feldspar as a source of potassium by soil application during soil preparation, In addition,treating pea seeds before sowing with four biological materials, i.e. phosphoren, potassiumag, rhizobium and mycorrhizal comparing with the normal fertilizer recommendation as control . It was found that adding rock phosphate + feldspar +rhizobium+ mycorrhizal and the treatment of rock phosphate + feldspar +rhizobium+ potassiumag +phosphoren respectively, were the favorable treatments on induce significant results on growth, i.e. plant height, number of leaves/ plant, fresh and dry weight/plant. The same treatments led to significant values on pod characters, i.e., pod weight, number of seeds/pod, weight of 100 seed and total green pods yield. Moreover the treatment of adding rock phosphate + feldspar + rhizobium + mycorrhizal induced significant increases in nitrogen concentration as well as protein content in the seeds, while the favorable treatment on increasing seed sugar content was treating the seeds with rhizobium and mycorrhizal. It was found also that adding rock phosphate +feldspar +mycorrhizal led to high phosphorus concentration in pea seeds. The treatment of foliar spray with ascobean induced significant increases in nitrogen, phosphorus and protein seed contents as well as leaf content from chlorophyll. The sugar concentration in pea seeds increased significantly by power-mix application. Generally it can be recommended by adding rock phosphate as natural source of phosphorus +feldspar as a source of natural potassium and treating pea seeds with rhizobium ,phosphorien , potassumag as a biological material and spray pea plants with ascobean or power –mix without adding any chemical fertilizers to produce high green pod yield with favorable quality comparing with the normal fertilizer recommendation.
DDDT_A_242521 621..633

Fengxia Lin* Yiying Yang* Shanyin Wei Xiaojing Huang Zhijian Peng Xiao Ke Zhicong Zeng Yinzhi Song 1Department of Cardiology, Shenzhen Bao’an Traditional Chinese Medicine Hospital Group, The Affiliated Hospital of Guangzhou University of Chinese Medicine, Shenzhen 518133, People’s Republic of China; 2Department of Cardiology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, People’s Republic of China; 3Department of Cardiology, Fuwai Hospital, Chinese Academy of Medical Sciences, (Shenzhen Sun Yat-sen Cardiovascular Hospital), Shenzhen 518057, People’s Republic of China
University of Birmingham A phase 2 study of Chronocort, a modified-release formulation of hydrocortisone, in the treatment of adults with classic congenital adrenal hyperplasia

27 Context: Treatment of congenital adrenal hyperplasia (CAH) is suboptimal. Inadequate suppression of 28 androgens and glucocorticoid excess are common and current glucocorticoid formulations cannot replace 29 the cortisol circadian rhythm. 30 Objectives : The primary objective was to characterize the pharmacokinetic profile of Chronocort ® , a 31 modified-release hydrocortisone formulation, in adults with CAH. Secondary objectives included 32 examining disease control following 6 months of Chronocort ® with dose titration. 33 34 Design, Setting and Patients: Sixteen adults (8 females) with classic CAH participated in an open label, 35 non-randomized, Phase 2 study at the National Institutes of Health Clinical Center. 24-hour blood 36 sampling was performed on conventional glucocorticoids and following 6 months of Chronocort ® . 37 Chronocort ® was initiated at 10mg (0700h) and 20mg (2300h). Dose titration was performed based on 38 androstenedione and 17-hydroxyprogresterone (17-OHP) levels and clinical symptomatology.
Characterization of the Kinase(s) Involved in the Phosphorylation of a- and ÃŸ-Z'-Deoxythioguanosine1

SUMMARY Studies were made on the phosphorylation of a- and (3-2'-deoxythioguanosine (a- and /3-TGdR) in crude extracts of several mouse tumors, normal mouse tissues, calf thymus, a series of human leukemic cell samples, and some solid human tumors. In general the rate of phosphorylation was higher for /3-TGdR than for a-TGdR. Deoxycytidine (CdR), 1-0-arabinofuranosylcy tosine (ara-C), and deoxyguanosine (GdR) were inhibitory to the phosphorylation of a- and /3-TGdR. Their effectiveness was greatest for, in decreasing order, CdR > ara-C > GdR. marrows a-TGdR, an Mg*, and the reaction was somewhat inhibited by dithioerythritol. Kinetic M and the KÂ¡'sfor GdR, CdR, and ara-C were 2.41 X IO'6, 3.60XKT8, and 1.69X 10~6M, respectively. Extracts of a cell line completely unable to phosphorylate ara-C (L1210/ara-C) were able to phosphorylate both a- and /3-TGdR at relatively high rates, and these substrates were not inhibited by ara-C. /3-TGdR apparently can be phosphorylated by the CdR-GdR kinase of tissues. However, another kinase is apparently present in some tissues and can phosphorylate both a- and /3-TGdR.
Population fluctuation and distribution of bemisia tabaci MEAM1 (Hemiptera: Aleyrodidae) in soybean crops

Studies on the spatiotemporal dynamics of crop pests enable the determination of their colonization pattern and dispersion in the landscape. Geostatistics is an efficient tool to determine the spatial distribution pattern of the pest in the crops and to visualize them in appropriate maps. Analysis of these maps across the crop developmental stages can be a helpful tool in precision agriculture programs. The aim of this study was to determine the spatiotemporal distribution of Bemisia tabaci whitefly adults and nymphs in commercial soybean crops from planting to harvest. Infestation by the whitefly adults and nymphs started between 30 and 50 days after plant emergence. The maximum population density of ten adults per plant and two nymphs per leaf occurred between 90 and 101 days after plant emergence. In Kriging maps, it was possible to observe the distribution pattern for both adults and nymphs. The colonization of soybean plants by B. tabaci may be divided into three stages: beginning infestation (at the outermost parts of the crop), whole area colonization, and dispersion colonization (when the whole crop area is infested). The density of adult insects was positively correlated with rainfall and relative humidity. Wind speed positively affected the dispersion of adult whiteflies. The distribution pattern of B. tabaci in the soybean crop was aggregated. Climatic factors, such as wind speed, increase the dispersion radius of the whitefly in the crop. Contribution to the field.
TRIB3 promoter 33 bp VNTR is associated with the risk of cerebrovascular disease in type 2 diabetic patients

Previous studies have demonstrated that TRIB3 is closely related to insulin resistance, metabolic disorders and vascular diseases. Recently, it was reported that a 33 bp variable number of tandem repeats (VNTR) located in the TRIB3 promoter could considerably alter its transcriptional activity. Nonetheless, whether the shift of TRIB3 transcriptional activity has the effect of inducing diabetic vascular complications is still unclear. Therefore, in our study, we aimed to explore the relationship between the TRIB3 33bp VNTR and diabetic vascular complications. The TRIB3 33bp VNTR polymorphisms were determined by PCR and Sanger sequencing, a total of 798 eligible Chinese patients with type 2 diabetes (T2DM) were included in our study and then evaluated with clinical data. After adjusting for age, gender, BMI, smoking history, drinking history and duration of diabetes, we found that the high number of 33 bp tandem repeats (repeats>8) was significantly associated with an increase in the risk of cerebrovascular diseases compared with the low number of 33 bp tandem repeats (repeats≤6) in patients with T2DM(OR 2.66, 95% CI 1.29–5.47, p = 0.008). The intermediate number of 33bp tandem repeats (6 < repeat≤8) was markedly associated with a decreased risk of diabetic retinopathy compared with the low number of tandem repeats (OR 0.65, 95% CI 0.46–0.91, p = 0.012). Adjusting for gender, age and BMI, there was a significant difference in DBP levels among patients with the number of different 33 bp tandem repeats (Low vs. Intermediate vs. High, 81.6 ± 12.8 vs. 79.8 ± 12.4 vs. 78.7 ± 12.6 mmHg; p = 0.045). Subgroup analysis found that TRIB3 VNTR was significantly correlated with the difference in systolic blood pressure (SBP) in T2DM patients taking ACEI/ARB drugs (Low vs. Intermediate vs. High, 146.27 ± 18.23 vs. 140.01 ± 19.91 vs. 140.77 ± 18.64 mmHg; p = 0.018). Our results indicated that TRIB3 promoter 33bp VNTR is related to vascular diseases in T2DM patients, and may serve as a new biomarker for individualized prevention and therapy of T2DM.
Monitoring of Bridge vibrations with image-assisted total stations.

Vibration-based Structural Health Monitoring (SHM) has become increasingly popular during the last years. Hereby, the frequencies of the structure’s oscillations form the basis of the structural diagnostics. The typically used measurement sensors for determining these frequencies include accelerometers and robotic total stations which comprise the drawback that access to the monitored structure is required. To overcome this limitation, the usage of an image-assisted total station (IATS) is proposed. Hereby, the measurement procedure is similar to measurements with conventional robotic total stations in which the retroreflective prism can be omitted for IATS measurements. Instead, prominent natural features of the monitored structure are observed by using the IATS’s telescope camera and later analyzed by means of image processing techniques. Along with a saving of costs, access to the monitored structure is not required which allows a more flexible definition of the measurement points. To demonstrate the suitability of an IATS for vibration monitoring, experimental measurements at different bridges were conducted with state-of-the-art IATSs and accelerometers as reference sensors.
Baseline of Physiological Body Temperature and Hematological Parameters in Captive Rousettus aegyptiacus and Eidolon helvum Fruit Bats

The discovery of bats as reservoir hosts for a number of highly pathogenic zoonotic agents has led to an increasing interest of infectious disease research in experimental studies with bats. Therefore, we established breeding colonies of Rousettus aegyptiacus and Eidolon helvum fruit bats, which both have been identified as reservoir hosts for relevant zoonotic disease agents, such as Marburg virus and Lagos bat virus. Since 2013, individuals of both species have been recruited to the Friedrich-Loeffler-Institut (FLI) from zoological gardens in Europe, to where these species had been introduced from the wild several decades ago. The aviaries have been designed according to national recommendations published by the Federal Ministry of Agriculture. Under these conditions, both species have been reproducing for years. To better understand the physiology of these animals, and to generate baseline knowledge for infection experiments, we monitored the body core temperatures of R. aegyptiacus bats in the aviaries, and found a circadian variation between 34°C and 41.5°C. We also determined the hematological parameters of both species, and detected specific differences between both bat species. For values of clinical chemistry, no correlation to age or sex was observed. However, species-specific differences were detected since ALT, BUN and CREA were found to be significantly higher in R. aegyptiacus and GLU and TP were significantly higher in E. helvum bats. A higher hematocrit, hemoglobin and red blood cell level was observed in subadult R. aegyptiacus, with hemoglobin and red blood cells also being significantly increased compared to E. helvum. Lymphocytes were found to be the dominant white blood cells in both species and are higher in female E. helvum. Neutrophil granulocytes were significantly higher in E. helvum bats. This underlines the necessity to define baseline profiles for each bat species prior to their use in experimental challenge.
Primitive genotypic characteristics in umbilical cord neutrophils identified by single-cell transcriptome profiling and functional prediction

The function and heterogeneity of neutrophils in neonatal umbilical cord blood (UCB) have not been characterized. In this study, we analyzed the neutrophils in UCB and healthy adults using single-cell RNA sequencing analysis for the first time. We found that neutrophils divided into six subpopulations (G2, G3, G4, G5a, G5b, and G5c) with different marker genes and different functions under homeostasis. Compared with healthy adults, neutrophils of UCB were more naïve and have more obvious degranulation and activation functions. Moreover, we found significant differences in the amount and function of G5b cells between healthy adults and UCB. The amount of G5b group in UCB was lower, but it has more degranulation, secretion and activation functions. In addition, we noted a new subset of G5c labeled by CD52, which almost did not exist in UCB. Besides, its differential genes were enriched in terms such as protein synthesis and mRNA transcription. Furthermore, uncharacteristic transcription factors ZNF-276, ZNF-319 and ZNF-354A were identified in our study. In summary, we first examined the heterogeneity and functional diversity of neutrophils in UCB, and these data provided new insights into the mechanism of neutrophil-mediated diseases of neonates and the wider use of neutrophils in UCB.