Miracle-dz/UniFAR-FTUs huggingface dataset:
Responding to harvest failure: Understanding farmers coping strategies in the semi-arid Northern Ghana

Farmers coping strategies against harvest failures have implication for future adaptation to such shocks. Previous studies on farmers’ vulnerability and response to shocks have emphasized on adaptation, at the expense of their coping to such shocks. Using a survey data from 299 farm households in northern Ghana, this study has analyzed farmers’ coping strategies against harvest failure, and the drivers of the choice and intensity of the coping strategies. The empirical results show that most of the households used liquidation of productive assets, reduction in consumption, borrowing from family and friends, diversification of livelihoods, and migration to cities for off-farm jobs as coping measures in response to harvest failure. The empirical results from a multivariate probit model indicate that the choice of coping strategies is influenced by farmers’ access to radio, net value of livestock produced per man-equivalent (ME), experience of yield loss in the previous year, farmers’ perception about the fertility status of their crop fields, access to credit, distance to market, farm-to-farmer extension, location of the respondent, cropland per ME, and access to off-farm income. Empirical results from a zero-truncated negative binomial regression model also indicate that the number of coping strategies adopted increases with the value of farm implements, access to radio, farmer-to-farmer extension and being located in the regional capital. It however decreases with the age of the household head, number of family members abroad, a positive perception about the fertility status of crop fields, access to government extension services, distance to market, and access to off-farm income. Limited access to credit, radio, and markets renders farmers more vulnerable and pushes them to adopt more costly coping strategies. In addition, an increase in income earned from secondary livestock products decreases incentive for farmers to adopt liquidation of productive assets as coping strategy after a harvest failure. Policy makers and stakeholders could make smallholder farmers less vulnerable to harvest failure by enhancing their access to radio, credit, off-farm income and market, promotion of farmer-to-farmer extension, implementing measure to improve the fertility of crop fields in the study area, and enhancing farmers’ engagement in the production and selling of secondary livestock products
Incidence and Clinical Phenotype of Multisystem Inflammatory Syndrome in Children After Two SARS-CoV-2 Pandemic Waves: A Croatian Prospective Nationwide Study

This prospective nationwide study in Croatia (March 1, 2020–December 31, 2021) embraced 121 children with multisystem inflammatory syndrome. Incidence rates, disease course and outcomes were similar to those reported from other European countries. The severe acute respiratory syndrome coronavirus 2 virus Alpha strain appeared associated with a higher propensity to result in multisystem inflammatory syndrome in children than the Delta strain but did not appear related to disease severity.
Do bone elasticity and postmortem interval affect forensic fractographic analyses?

Forensic fractographic features of bone reliably establish crack propagation in perimortem injuries. We investigated if similar fracture surface features characterize postmortem fractures. Experimentally induced peri‐ and postmortem fractures were used to assess if fractographic features vary as bone elasticity decreases during the postmortem interval (PMI). Thirty‐seven unembalmed, defleshed human femoral shafts from males and females aged 33–81 years were fractured at varying PMIs with a drop test frame using a three‐point bending setup and recorded with a high‐speed camera. Vital statistics, cause of death, PMI length, temperature, humidity, collagen percentage, water loss, fracture energy, and fractography scores were recorded for each sample. Results showed that fractographic features associated with perimortem fractures were expressed in PMIs up to 40,600 accumulated degree hours (ADH), or 60 warm weather days. Hackle was the most consistently expressed feature, occurring in all fractures regardless of ADH. The most variable characteristics were wake features (78.4%) and arrest ridges (70.3%). Collagen percentage did not correlate strongly with ADH (r = −0.04, p = 0.81); however, there was a strong significant correlation between ADH and water loss (r = 0.74, p < 0.001). Multinomial logistic regression showed no association between fractographic feature expression and ADH or collagen percentage. In conclusion, forensic fractographic features reliably determine initiation and directionality of crack propagation in experimentally induced PMIs up to 40,600 ADH, demonstrating the utility of this method into the recent postmortem interval. This expression of reliable fractographic features throughout the early PMI intimates these characteristics may not be useful standalone features for discerning peri‐ versus postmortem fractures.
SGLT2i reduces risk of developing HCC in patients with co-existing type 2 diabetes and hepatitis B infection: A territory-wide cohort study in Hong Kong

Background and Aims: Type 2 diabetes (T2D) and chronic hepatitis B infection (CHB) are risk factors of HCC. Sodium glucose co-transporter 2 inhibitors (SGLT2i) inhibit HCC oncogenesis in preclinical studies. However, clinical studies are lacking. This study aimed to evaluate the impact of SGLT2i use on incident HCC using a territory-wide cohort of exclusively patients with co-existing T2D and CHB. Approach and Results: Patients with co-existing T2D and CHB between 2015 and 2020 were identified from the representative electronic database of the Hong Kong Hospital Authority. Patients with and without SGLT2i use were 1:1 matched by propensity score for their demographics, biochemistry results, liver-related characteristics, and background medications. Cox proportional hazards regression model was used to assess the association between SGLT2i use and incident HCC. A total of 2,000 patients with co-existing T2D and CHB (1,000 in each SGLT2i and non-SGLT2i group; 79.7% on anti-HBV therapy at baseline) were included after propensity-score matching. Over a follow-up of 3,704 person-years, the incidence rates of HCC were 1.39 and 2.52 cases per 100 person-year in SGLT2i and non-SGLT2i groups, respectively. SGLT2i use was associated with a significantly lower risk of incident HCC (HR 0.54, 95%CI: 0.33-0.88, p=0.013). The association remained similar regardless of sex, age, glycemic control, diabetes duration, presence of cirrhosis and hepatic steatosis, timing of anti-HBV therapy, and background antidiabetic agents including dipeptidyl peptidase-4 inhibitors, insulin, or glitazones (all p interaction>0.05). Conclusions: Among patients with co-existing T2D and CHB, SGLT2i use was associated with a lower risk of incident HCC.
Effects of glycemic control on frailty: a multidimensional perspective

ABSTRACT Diabetes prevalence increases with increasing age due to increased life expectancy. In older people with diabetes, frailty is an emerging diabetes-related complication. Although the literature is focused on the physical decline as the main manifestation of frailty, other domains such as cognitive and emotional dysfunction are commonly associated with physical frailty constituting a triad of impairment (TOI). The TOI is a better predictor of adverse outcomes than physical frailty alone. Previous diabetes studies focused on cardiovascular events as the main outcome with little data exploring the effect of glycemic control on frailty as a multidimensional perspective. Current evidence suggests that poor glycemic control may be associated with an increased risk of the three components of the TOI, however, the association of tighter glycemic control and the risk of TOI is inconsistent. In general HbA1c range of 6.5–7.9% appears to be less associated with TOI, while HbA1c > 8.0% is associated with a higher risk although most of the studies have limitations such as retrospective or cross-sectional design. So far, there is very little evidence from clinical trials to suggest that tight glycemic control would prevent or delay the development of frailty as a wide spectrum of physical, cognitive or emotional dysfunction. Therefore, future clinical trials are required to explore the effect of tight glycemic control on the multidimensional aspect of frailty as the main outcome. However, tight glycemic control in older people is associated with increased risk of hypoglycemia, which increases the risk of frailty. Therefore, novel hypoglycemic agents with intrinsic properties to reduce the risk of frailty, independent of glycemic control, are also required.
A self-regularized approach for rank-deficient systems in the BEM of 2D Laplace problems

Abstract The Laplace problem subject to the Dirichlet or Neumann boundary condition in the direct and indirect boundary element methods (BEM) sometimes both may result in a singular or ill-conditioned system (some special situations) for the interior problem. In this paper, the direct and indirect BEMs are revisited to examine the uniqueness of the solution by introducing the Fichera’s idea and the self-regularized technique. In order to construct the complete range of the integral operator in the BEM lacking a constant term in the case of a degenerate scale, the Fichera’s method is provided by adding the constraint and a slack variable to circumvent the problem of degenerate scale. We also revisit the Fredholm alternative theorem by using the singular value decomposition (SVD) in the discrete system and explain why the direct BEM and the indirect BEM are not indeed equivalent in the solution space. According to the relation between the SVD structure and Fichera’s technique, a self-regularized method is proposed in the matrix level to deal with non-unique solutions of the Neumann and Dirichlet problems which contain rigid body mode and degenerate scale, respectively, at the same time. The singularity and proportional influence matrices of 3 by 3 are studied by using the property of the symmetric circulant matrix. Finally, several examples are demonstrated to illustrate the validity and the effectiveness of the self-regularized method.
The Temporal Dynamics of Brain-to-Brain Synchrony Between Students and Teachers Predict Learning Outcomes

Much of human learning happens through interaction with other people, but little is known about how this process is reflected in the brains of students and teachers. Here, we concurrently recorded electroencephalography (EEG) data from nine groups, each of which contained four students and a teacher. All participants were young adults from the northeast United States. Alpha-band (8–12 Hz) brain-to-brain synchrony between students predicted both immediate and delayed posttest performance. Further, brain-to-brain synchrony was higher in specific lecture segments associated with questions that students answered correctly. Brain-to-brain synchrony between students and teachers predicted learning outcomes at an approximately 300-ms lag in the students’ brain activity relative to the teacher’s brain activity, which is consistent with the time course of spoken-language comprehension. These findings provide key new evidence for the importance of collecting brain data simultaneously from groups of learners in ecologically valid settings.
Bias Correction and Forecast Skill of NCEP GFS Ensemble Week-1 and Week-2 Precipitation, 2-m Surface Air Temperature, and Soil Moisture Forecasts

AbstractA simple bias correction method was used to correct daily operational ensemble week-1 and week-2 precipitation and 2-m surface air temperature forecasts from the NCEP Global Forecast System (GFS). The study shows some unexpected and striking features of the forecast errors or biases of both precipitation and 2-m surface air temperature from the GFS. They are dominated by relatively large-scale spatial patterns and low-frequency variations that resemble the annual cycle. A large portion of these forecast errors is removable, but the effectiveness is time and space dependent. The bias-corrected week-1 and week-2 ensemble precipitation and 2-m surface air temperature forecasts indicate some improvements over their raw counterparts. However, the overall levels of week-1 and week-2 forecast skill in terms of spatial anomaly correlation and root-mean-square error are still only modest. The dynamical soil moisture forecasts (i.e., land surface hydrological model forced with bias-corrected precipitation a.
A magnified compact galaxy at redshift 9.51 with strong nebular emission lines

Ultraviolet light from early galaxies is thought to have ionized gas in the intergalactic medium. However, there are few observational constraints on this epoch because of the faintness of those galaxies and the redshift of their optical light into the infrared. We report the observation, in JWST imaging, of a distant galaxy that is magnified by gravitational lensing. JWST spectroscopy of the galaxy, at rest-frame optical wavelengths, detects strong nebular emission lines that are attributable to oxygen and hydrogen. The measured redshift is z = 9.51 ± 0.01, corresponding to 510 million years after the Big Bang. The galaxy has a radius of 16.2−7.2+4.6 parsecs, which is substantially more compact than galaxies with equivalent luminosity at z ~ 6 to 8, leading to a high star formation rate surface density. Description Editor’s summary The expansion of the Universe causes the light from distant galaxies to be redshifted to longer wavelengths. Candidate distant galaxies can be identified using imaging, but confirming their redshift requires spectroscopy. Williams et al. used near-infrared imaging and spectroscopy to identify a galaxy at redshift 9.5, corresponding to about 500 million years after the Big Bang. Little is known about galaxies at that early time. Emission lines in the spectrum allowed the authors to determine some of the galaxy’s physical properties, such as its abundance of elements heavier than helium, and they found that it is very compact and has a high density of star formation. —Keith T. Smith Spectroscopy of a compact galaxy at redshift 9.5 determines its physical properties only 500 million years after the Big Bang.
CAGE‐B and SAGE‐B models better predict the hepatitis B virus‐related hepatocellular carcinoma after 5‐year entecavir treatment than PAGE‐B

The PAGE‐B model consists of variables at the initiation of antiviral therapy (AVT), whereas the SAGE‐B and CAGE‐B models consist of variables after 5 years of AVT. We aimed to compare the predictive accuracy of three risk prediction models for hepatocellular carcinoma (HCC) development after 5 years of AVT in patients with chronic hepatitis B (CHB).
Thickness Dependence of Properties of ZnO Thin Films on Porous Silicon Grown by Plasma-assisted Molecular Beam Epitaxy

Zinc oxide (ZnO) thin films with different thicknesses were grown on Si and porous silicon (PS) by plasma-assisted molecular beam epitaxy (PA-MBE). The effects of the thickness and PS on the properties of the ZnO thin films were investigated by scanning electron microscopy (SEM), X-ray diffraction (XRD), and photoluminescence (PL). The ZnO thin films grown on PS exhibit a very smooth surface morphology even at a growth time of 5 min, which indicates that the films are in the 2D mode of grain growth. It is suggested that the optical properties, as well as the structural properties, of the ZnO thin films are enhanced by introducing PS. Also, the structural and the optical properties are improved as the thickness is increased.
Flow Pressure Characteristics of the Ahmed Glaucoma Valve and Possible Effect of Entrapped Air in the Tube

Purpose The purpose of this study was to assess the pressure characteristics of the Ahmed Glaucoma Valve (AGV) and possible effects of air trapped in the tube. Method Physiologic saline was pumped through 17 AGVs using a syringe infusion pump, and the flow pressure was measured by a set of pressure transducers. During the infusion at a rate of 2 µL/minute, the pressure measurement was repeated twice in each AGV to determine the repriming pressures with/without air (1 µL) in the tube. Results After a pressure surge occurred during the initial priming, the pressure decreased suddenly and then became constant. The repriming pressure, determined as the peak pressure before valve opening, was significantly (P < 0.0001, paired t-test) higher with air (26.5 ± 6.8 mm Hg) than without air (12.1 ± 3.8 mm Hg), whereas the constant pressures after repriming was equivalent between with (10.6 ± 3.7 mm Hg) and without (10.4 ± 2.9 mm Hg) air conditions (P = 0.68). Conclusions Air in the AGV tube causes increased repriming pressure of about two-fold compared to repriming without air. This pressure increment caused by air in the capillary-sized tube might occur because of the effects of viscosity pressure and capillary pressure. Translational Relevance To ensure stable surgical results, surgeons are advised to not allow air to remain in the tube. Pars plana tube insertion of the AGV combined with gas tamponade surgery may result in higher-than-expected intraocular pressure. Conversely, injection of air/gas can avoid postoperative hypotony when the AGV is implanted in eyes with a high risk of hypotony.
The Influence of Helicity on Numerically Simulated Convective Storms

Abstract A three-dimensional numerical cloud model is used to investigate the influence of storm-relative environmental helicity (SREH) on convective storm structure and evolution, with a particular emphasis on the identification of ambient shear profiles that are conducive to the development of long-lived, strongly rotating storms. Eleven numerical simulations are made in which the depth and turning angle of the ambient vertical shear vector are varied systematically while maintaining a constant magnitude of the shear in the shear layer. In this manner, an attempt is made to isolate the effects of different environmental Felicities on storm morphology and show that the SREH and bulk Richardson number, rather than the mean shear in the low levels, determine the rotational characteristics and morphology of deep convection. The results demonstrate that storms forming in environments characterized by large SREH are longer-lived than those in less helical surroundings. Further, it appears that the storm-relat.
A Phase 1 study for safety and pharmacokinetics of BIO101 (20‐hydroxyecdysone) in healthy young and older adults

Sarcopenia is an age‐related skeletal muscle disorder characterized by loss of muscle mass and strength leading to mobility disability. 20‐Hydroxyecdysone (20E) is a polyhydroxylated plant steroid that demonstrates pharmacological effects in many disease animal models including ageing/sarcopenia. BIO101 is a 20E purified investigational drug (≥97%) that previously demonstrated good toxicology profiles in rat and dog. BIO101 is evaluated in healthy young and older adults in a Phase 1 study.
Atmospheric Precipitation in Response to Equatorial and Tropical Sea Surface Temperature Anomalies

Abstract Three sets of numerical experiments based on a GFDL GCM were developed to investigate the response of the large-scale tropical circulation and precipitation to the tropical and equatorial sea surface temperature (SST) anomalies. Specified SST anomaly (SSTA) with a small latitudinal scale of 13.5° was imposed in different regions of the Pacific Ocean in different sets of experiments and added to the climate-mean August SST to form a lower boundary forcing. Each set is composed of two experiments in which the SSTA possesses the same coverage and intensity but opposite sign. Anomalies of meteorological fields are calculated as the differences between the results of the warm and cold SSTA experiments. In all experiments, prominent anomalous low-level convergence and high-level divergence are observed over the warm SSTA regions. For experiments with warm SSTA placed at the equator, responses of the tropical streamfunction are similar to corresponding results found in other studies. When the warm SSTA .
Plasma exchange in inflammatory demyelinating disorders of the central nervous system: reasonable use in the clinical practice

Abstract Plasma exchange (PLEX) is a therapeutic apheresis modality in which the plasma is separated from inflammatory factors such as circulating autoreactive immunoglobulins, the complement system, and cytokines, and its therapeutic effect is based on the removal of these mediators of pathological processes. Plasma exchange is well established for various neurological disorders, and it is applied successfully in central nervous system inflammatory demyelinating diseases (CNS-IDD). It mainly modulates the humoral immune system; thus, it has a greater theoretical effect in diseases with prominent humoral mechanisms, such as neuromyelitis optica (NMO). However, it also has a proven therapeutic effect in multiple sclerosis (MS) attacks. Several studies have suggested that patients with severe attacks of CNS-IDD have poor response to steroid therapy but show clinical improvement after the PLEX treatment. Currently, PLEX is generally established only as a rescue therapy for steroid unresponsive relapses. However, there are still research gaps in the literature regarding plasma volume, number of sessions, and how early the apheresis treatment needs to started. Thus, in the present article, we summarize the clinical studies and meta-analyses, especially about MS and NMO, outlining clinical data regarding the experience with therapeutic PLEX in severe attacks of CNS-IDD, the clinical improvement rates, the prognostic factors of a favorable response, and highlighting the likely role of the early apheresis treatment. Further, we have gathered this evidence and suggested a protocol for the treatment of CNS-IDD with PLEX in the routine clinical practice.
Scanning Acoustic Microscope with Transducer Swing Along Beam Axis

A transducer swing mechanism is introduced to accomplish a new scanning acoustic microscope system in the interference mode, which is applied to the quantitative measurement of acoustic velocities in thin materials. In this system, the distance between a pair of aligned focusing transducers along the beam axis is varied periodically, as the specimen is synchronously scanned in the X direction. Measurements of acoustic velocities are performed with this system for two kinds of polymer film, polyester and PVF2 films, and a dog's cardiac infarcted tissue at a frequency of 150 MHz.
Novel Developments in Advanced Materials Fields: Porous and Non-Porous Biomaterials Used in Regenerative Medicine and Tissue Engineering

Abstract In this brief review, porous and non-porous biomaterials used as scaffolds in regenerative medicine and tissue engineering and new innovative techniques to obtain biomaterials were discussed. Various methods have been presented to obtain advanced materials used as scaffolds, such as (i) 3D printed biomineral composites obtained with bacteria-loaded ink (bactoInk), (ii) the use of vegetable waste, such as rice husks, parsley, spinach or cocoa in the development of bioplastics, (iii) the use of natural biological materials of animal origin (such as bovine bones, corals, snail shells or eggshells) from waste, or (iv) the creation of new biomaterials that can reduce or combat the infection of scaffolds after implantation.