Miracle-dz/UniFAR-FTUs huggingface dataset:
Effect of FYM and GA3 on Growth and Yield of Sweet Flag (Acorus calamus L.) under Terai Zone of West Bengal

A field experiment was conducted during 2003 - 04 and 2004 - 05 at the Instructional Farm of Uttar Banga Krishi Viswavidyalaya, Pundibari, Cooch Behar, West Bengal, to study the effect of different levels of Farm Yard Manure (FYM) (0, 12.5, 25, 37.5 and 50 t ha-1) and GA3 (0 and 100 ppm) on production in Sweet Flag. The experiment was laid out in Factorial Randomized Block Design with three replications. Farm Yard Manure significantly affected yield and vegetative characters. GA3 also showed similar effect, except, that rhizome diameter and dry-recovery percentage were found non-significant. Interaction effect between FYM and GA3 for growth and yield parameters was found nonsignificant. Plant height, number of leaves, rhizome length, rhizome diameter and yield increased with increase in dose of FYM from 0 to 50 t ha-1 but was reverse in the case of dry recovery. Similarly, these parameters increased with application of GA3 but showed non-significant relationship, except in rhizome yield. Maximum fresh and dry rhizome yield (3013.23 kg ha-1, 1389.15 kg ha-1 respectively) was recorded with 50 t ha-1 FYM supplemented with 100 ppm GA3-, followed by application of 50 t ha-1 FYM (2879.80 and 1342.65 kg ha-1, respectively).
Fifty years of evolutionary trajectory of tourism industry regulations: a systematic literature review

ABSTRACT The purpose of this systematic literature review is to examine the developments in global tourism industry regulations over time. We examined 416 peer-reviewed articles published in Social Science Citations Indexed journals. The findings show that the number of publications in the field of study have been declining recently and tourism in developed countries have been the primary focus of most studies. Only a few studies used appropriate theoretical insights to inform respective investigations. While the findings of the present study serve as a literature roadmap for future research, they can also help spark scholarly conversations in the field of study.
Short-Chain Fatty Acids Modulate Sperm Migration through Olfactory Receptor 51E2 Activity

The non-orthotopic expression of olfactory receptors (ORs) includes the male reproductive system, and in particular spermatozoa; their active ligands could be essential to sperm chemotaxis and chemical sperm–oocyte communication. OR51E2 expression has been previously reported on sperm cells’ surface. It has been demonstrated in different cellular models that olfactory receptor 51E2 (OR51E2) binds volatile short-chain fatty acids (SCFAs) as specific ligands. In the present research, we make use of Western blot, confocal microscopy colocalization analysis, and the calcium-release assay to demonstrate the activation of sperm cells through OR51E2 upon SCFAs stimulus. Moreover, we perform a novel modified swim-up assay to study the involvement of OR51E2/SCFAs in sperm migration. Taking advantage of computer-assisted sperm analysis (CASA system), we determine the kinematics parameters of sperm cells migrating towards SCFAs-enriched medium, revealing that these ligands are able to promote a more linear sperm-cell orientation. Finally, we obtain SCFAs by mass spectrometry in cervico-vaginal mucus and show for the first time that a direct incubation between cervical mucus and sperm cells could promote their activation. This study can shed light on the possible function of chemosensory receptors in successful reproduction activity, laying the foundation for the development of new strategies for the treatment of infertile individuals.
Influenza Vaccination among Multiple Sclerosis Patients during the COVID-19 Pandemic

In the context of the COVID-19 pandemic, the co-circulation of influenza and SARS-CoV-2 viruses may have severe complications for vulnerable populations. For this reason, the World Health Organization pointed to the 2020–2021 anti-influenza campaign as being of special relevance. Our aim was to assess the 2020–2021 influenza vaccination coverage, and its associated factors, among patients in a Spanish multiple sclerosis (MS) unit. A cross–sectional study was conducted. People attending the MS unit of the Clinical Hospital of Zaragoza during 2020 were included. Variables were obtained by reviewing records. Associations with 2020–2021 influenza vaccination were analyzed using bivariate analysis and a multiple logistic regression model. A total of 302 patients were studied; 62.6% were women, whose mean age (standard deviation) was 47.3 (11.5) years. The 2020–2021 influenza vaccination coverage was 55.3% (59.8% in women and 47.8% in men). A total of 89.7% had at least one other indication for vaccination (e.g., immunosuppressive treatment in 225 patients). The variables associated with getting vaccinated were being female (adjusted odds ratio (95% confidence interval) (aOR (95%CI) = 2.12 (1.12–3.99)), having received the 2019–2020 influenza vaccine (aOR (95%CI) = 31.82 (14.71–68.86)) and being born in Spain (aOR (95%CI) = 12.91 (1.07–156.28)). Coverage is moderate compared to other countries. It is necessary to develop strategies to improve it, especially in men and those born outside Spain.
The Reanalysis of the Donation Data Using the Zero-Inflated Possion Regression

Kim et al. (2006) analyzed the donation data surveyed by Voluneteer 21 in year 2002 at South Korea using a Poisson regression based on the mixture of two Poissons and detected significant variables for affecting the number of donations. However, noting the large deviation between the predicted and the actual frequencies of zero, we developed in this note a Poisson regression model based on a distribution in which zero inflated Poisson was added to the mixture of two Poissons. Thus the population distribution is now a mixture of three Poissons in which one component is concentrated on zero mass. We used the EM algorithm for estimating the regression parameters and detected the same variables with Kim et al's for significantly affecting the response. However, we could estimate the proportion of the fixed zero group to be 0.201, which was the characteristic of this model. We also noted that among two significant variables, the income and the volunteer experience(yes, no), the second variable could be utilized as a strategric variable for promoting the donation.
Her-2 Targeted Therapy in Advanced Urothelial Cancer: From Monoclonal Antibodies to Antibody-Drug Conjugates

Metastatic urothelial cancer, associated with a poor prognosis, is still major cause of cancer-related death, with scarce options of effective treatment after progression to platinum-based chemotherapy and immunotherapy. The human epithelial growth factor receptor 2 (Her-2) has been identified as a new therapeutic target in medical oncology. However, despite the encouraging results in breast and gastric cancers, clinical trials with anti-Her-2 monoclonal antibodies and tyrosine-kinase inhibitors have shown limited efficacy of this strategy in urothelial tumors. Notably, more favorable data have been recently shown that antibody-drug conjugates are currently emerging as a novel promising approach for Her-2 targeted therapy in advanced urothelial cancer.
Salt-related practices and its association with 24-hour urinary sodium excretion in an Uruguayan population cohort

Abstract Objectives. To evaluate the association between knowledge, attitudes, and behavior (KAB) towards sodium use and sodium intake measured by 24-hour urinary collection in an adult cohort from Uruguay (Genotype Phenotype and Environment of Hypertension Study, GEFA-HT-UY). Methods. In a cross-sectional study (n = 159), a single 24-hour urinary sample, participants' physical, biochemical and blood pressure measurements and questionnaire data were collected. The association between KAB and 24-hour urinary sodium excretion was assessed using general linear models. Results. Mean age of participants was 49.8±15.5 years, 67.9% were women, and mean 24-hour urinary sodium excretion was 3.6±1.7 g/day. Although 90.6% of participants exceeded the maximum recommended intake as indicated by urinary sodium excretion, more than half misperceived their actual intake, reporting consuming “the right amount. ” Almost three-quarters of the participants reported being concerned about the amount of sodium in their diet, but only 52.8% reported taking action to control it. Lack of procedural knowledge was observed. There was no association between KAB and sodium use and intake assessed by 24-hour urinary sodium excretion. Conclusions. The lack of association between KAB towards the use of sodium and intake measured by 24-hour urinary excretion reflects the need to support people with opportunities and motivations to reduce sodium consumption. Structural actions to promote an adequate food environment, such as the effective implementation of the front-of-package nutrition labeling in Uruguay, are positive steps.
The core of the massive cluster merger MACS J0417.5−1154 as seen by VLT/MUSE

We present a multiwavelength analysis of the core of the massive galaxy cluster MACS J0417.5−1154 (⁠z = 0.441). Our analysis takes advantage of Very Large Telescope/Multi-Unit Spectroscopic Explorer observations which allow the spectroscopic confirmation of three strongly lensed systems. System #1, nicknamed The Doughnut, consists of three images of a complex ring galaxy at z = 0.8718 and a fourth, partial and radial image close to the brightest cluster galaxy (BCG) only discernible thanks to its strong [O II] line emission. The best-fitting mass model (rms of 0.38 arcsec) yields a two-dimensional enclosed mass of M(R 3) = 0.22 arcmin2, which confirms MACS J0417 as an efficient gravitational lens.
Expected Yields of Planet discoveries from the TESS primary and extended missions

We present a prediction of the transiting exoplanet yield of the TESS primary mission, in order to guide follow-up observations and science projects utilizing TESS discoveries. Our new simulations differ from previous work by using (1) an updated photometric noise model that accounts for the nominal pointing jitter estimated through simulation prior to launch, (2) improved stellar parameters based on Gaia mission Data Release 2, (3) improved empirically-based simulation of multi-planet systems, (4) a realistic method of selecting targets for 2-minute exposures, and (5) a more realistic geometric distortion model to determine the sky region that falls on TESS CCDs. We also present simulations of the planet yield for three suggested observing strategies of the TESS extended mission. We report ~$10^4$ planets to be discovered by the TESS primary mission, as well as an additional $\sim 2000$ planets for each year of the three extended mission scenarios we explored. We predict that in the primary mission, TESS will discover about 3500 planets with Neptune size and smaller, half of which will orbit stars with TESS magnitudes brighter than 12. Specifically, we proposed a new extended mission scenario that centers Camera 3 on the ecliptic pole (C3PO), which will yield more long period planets as well as moderately irradiated planets that orbit F, G, and K stars.
Points of persuasion: Truth spots in future city development

Geographers and historians have contributed to a well-established literature on how places become repositories of inherited meanings and contested memories. Much less attention has been afforded to space and place as future-making resources. In this article, we consider how extant places feature in the imagination, planning and development of ex novo cities. Focusing on three new administrative capitals in Southeast Asia – Putrajaya (in Malaysia), Naypyidaw (in Myanmar) and Nusantara (in Indonesia) – we show how places have been mobilized as points of persuasion, or what sociologist Thomas Gieryn has termed “truth spots”. Drawing and building upon Gieryn’s work, we identify three heuristic types of truth spots: aspirational truth spots that demonstrate progressive developmental possibilities for emulation; antithetical truth spots signaling past failures to avoid in planning and developing the future city; and anticipatory truth spots that articulate future expectations, justifying forms of (in)action in the present. While existing work on truth spots emphasizes powers of persuasion associated with physical, in-person experiences of place, our emphasis and contribution centres on the narrative mobilization of place references.
Comparative Study of the Compressive Strength of Concrete made from Different Brands of Cements in Ghana

There is an on-going debate about the strength and durability of the different brands of cements used for construction in Ghana. This has raised doubts on the quality and performance of the strength of the different brands of cements. Concrete is a composite material made of aggregates such as sand and stone that are mixed uniformly in the required proportion together with water for it to achieve the desired strength in its development. Cement is an important ingredient that binds together other building materials by a combination of chemical processes known as setting. Among the various physical properties of cement, compressive strength is the most vital property which gives an overall assessment of quality of concrete as the strength of concrete shows the ability of the structure to withstand various loads during it lifelong performance after construction. This research investigated the compressive strength of six different brands of 32.5R and 42.5R cements used for construction works in Ghana, namely, CIMAF cement, DIAMOND cement, GHACEM cement, SOL cement, SUPACEM cement and DANGOTE cement. Among the 32.5R brands, GHACEM cement developed the highest 28th day compressive strength of 30.96 N/mm2 and CIMAF cement the lowest strength of 25.89 N/mm2. In the 42.5R group, DANGOTE had the highest 28th compressive strength of 37.19N/mm2 while SOL produced the lowest with 31.11N/mm2.
A Cross-Sectional Research on Proactive Safety Behavior of The Young Malaysian Workers

Young workers, aged between 18 to 29 years old, make up over 18 percent of the Malaysian working-age population. Poor workplace safety is a major concern for these young Malaysian workers, with relatively high levels of workplace accidents and injuries being recorded. This study investigates young workers’ proactive safety behavior practices, defined as anticipatory, change-oriented, and self-initiated behavior in sustaining workplace safety in situations where management safety controls are often neglected. The study was conducted with a cross-sectional design that had its focal point in identifying the predictors of proactive safety behavior in an individual’s dai ly working experiences. 215 young workers aged between 18 to 28 years old participated in this research represented various industries. The Hierarchical Multiple Linear Regresion indicated a significant relationship with this block of variables and proactive safety behavior at Time 1 [F (11,203) = 8.01, p<. 01]. Proactive motivation (Can do) is the strongest predictor of proactive safety behavior (β=.41), followed by proactive motivation (Reason to) at β=. 20.
Analysis of prognostic oncogene filaggrin (FLG) wild-type subtype and its implications for immune checkpoint blockade therapy in bladder urothelial carcinoma

Background Bladder urothelial carcinoma (BLCA) is one of the most common urinary tract malignant tumors. Immune checkpoint blockade (ICB) therapy has significantly progressed the treatment of BLCA. This study aimed to investigate the role of specific genetic mutations that may serve as immune biomarkers for ICB therapy in BLCA. Methods Mutation information and expression profiles were acquired from The Cancer Genome Atlas (TCGA) database. Integrated bioinformatics analysis was carried out to explore the subtypes with poor prognosis of BLCA. Functional enrichment analysis was also conducted. The infiltrating immune cells and the prediction of ICB response between different subtypes were explored using the immuCellAI algorithm. Cell Counting Kit-8 (CCK-8) and flow cytometry assays were conducted to explore the effect of filaggrin (FLG) knockdown in BLCA 5637 and T24 cell lines. Results An overview of mutation information in BLCA patients was shown. FLG was identified to be strongly associated with the prognosis of BLCA patients and FLG wild-type was associated with poorer outcome. Prognostic FLG wild-type was divided into 2 subtypes (Sub1 and Sub2). Following an investigation of the subtypes, Sub2 of FLG wild-type was found to be associated with poorer outcome in BLCA. The differentially expressed genes (DEGs) between Sub1 and Sub2 were screened out and the DEGs were enriched in malignant tumor proliferation, DNA damage repair, and immune-related pathways. Furthermore, Sub2 of FLG wild-type was associated with infiltrated immune cells, and responded worse to ICB. Sub2 of FLG wild-type may be used as a biomarker to predict the prognosis of BLCA patients receiving ICB. The cellular experiments revealed that knockdown of FLG could suppress BLCA cell proliferation and promote apoptosis. Conclusions FLG is an oncogene that may affect the prognosis of BLCA patients through mutation. Sub2 of FLG wild-type is associated with poor prognosis and can be used to predict ICB response for BLCA treatment. This research provides a new basis and ideas for guiding the clinical application of BLCA immunotherapy.
Unified treatment of current-induced instabilities on Si surfaces

We introduce a simple two region model where the diffusion constant in a small region around each step on a vicinal surface can differ from that found on the terraces. Steady state results for this model provide a physically suggestive mapping onto kinetic coefficients in the conventional sharp-step model, with a negative coefficient arising from faster diffusion in the step region. A linear stability analysis of the resulting sharp-step model provides a unified and simple interpretation of many experimental results for current-induced step bunching and wandering instabilities on both Si(111) and Si(001) surfaces.
Topological Spin Excitations in Honeycomb Ferromagnet 
CrI3

In two dimensional honeycomb ferromagnets, bosonic magnon quasiparticles (spin waves) may either behave as massless Dirac fermions or form topologically protected edge states. The key ingredient defining their nature is the next-nearest neighbor Dzyaloshinskii-Moriya (DM) interaction that breaks the inversion symmetry of the lattice and discriminates chirality of the associated spin-wave excitations. Using inelastic neutron scattering, we find that spin waves of the insulating honeycomb ferromagnet CrI$_3$ ($T_C=61$ K) have two distinctive bands of ferromagnetic excitations separated by a $\sim$4 meV gap at the Dirac points. These results can only be understood by considering a Heisenberg Hamiltonian with DM interaction, thus providing experimental evidence that spin waves in CrI$_3$ can have robust topological properties useful for dissipationless spintronic applications.
Clinical and resistance characterization of carbapenem-resistant Klebsiella pneumoniae isolated from intensive care units in China

Background Carbapenem-resistant Klebsiella pneumoniae (CRKP) is a serious threat to health, and the detection rate in intensive care units (ICUs) is relatively high. We compared regional differences in the clinical and molecular characteristics of CRKP from three ICUs in different hospitals, to make a reference and contribution for infection control and clinical medication. Methods A total of 150 CRKP strains from Chongqing, Beijing, and Nantong, as well as the clinical data of the infected patients, were collected between 2019 and 2021. The carbapenemase phenotype was determined by CarbaNP test, and the outer membrane porin (OMP) genes (ompK35/ompK36), multi-locus sequence typing (MLST) and resistance genes were identified by polymerase chain reaction (PCR) amplification and sequencing. Results Patients infected with CRKP were mainly elderly, with comorbidity, and had undergone invasive operation and multiple antibiotic therapy. All strains exhibited high-level resistance to most antibiotics except for polymyxin B and tigecycline. Among the CRKP strains, 100 had the blaKPC-2 gene and 8 had blaNDM-1 gene, which were distributed in all of the hospitals. Nearly all the strains harbored extended-spectrum beta-lactamase (ESBL) genes (blaSHV, blaCTX-M, and blaTEM). Class C carbapenemase genes (blaCIT, blaDHA), and deletion and mutation of ompK35/ompK36 existed in some strains. ST11 was the main MLST type, followed by ST15. Conclusions There were a few significant differences in the molecular epidemiology and clinical characteristics, but generally the features of CRKP from the three ICUs aligned fairly well, which might have resulted from dissemination through frequent personnel exchanges between regions.
Purity, formality, and arrangement complements

We prove a "purity implies formality" statement in the context of the rational homotopy theory of smooth complex algebraic varieties, and apply it to complements of hypersurface arrangements. In particular, we prove that the complement of a toric arrangement is formal. This is analogous to the classical formality theorem for complements of hyperplane arrangements, due to Brieskorn, and generalizes a theorem of De Concini and Procesi.
GASP. IX. Jellyfish galaxies in phase-space: an orbital study of intense ram-pressure stripping in clusters

It is well known that galaxies falling into clusters can experience gas stripping due to ram-pressure by the intra-cluster medium (ICM). The most spectacular examples are galaxies with extended tails of optically-bright stripped material known as "jellyfish". We use the first large homogeneous compilation of jellyfish galaxies in clusters from the WINGS and OmegaWINGS surveys, and follow-up MUSE observations from the GASP MUSE programme to investigate the orbital histories of jellyfish galaxies in clusters and reconstruct their stripping history through position vs. velocity phase- space diagrams. We construct analytic models to define the regions in phase-space where ram-pressure stripping is at play. We then study the distribution of cluster galaxies in phase-space and find that jellyfish galaxies have on average higher peculiar velocities (and higher cluster velocity dispersion) than the overall population of cluster galaxies at all clustercentric radii, which is indicative of recent infall into the cluster and radial orbits. In particular, the jellyfish galaxies with the longest gas tails reside very near the cluster cores (in projection) and are moving at very high speeds, which coincides with the conditions of the most intense ram-pressure. We conclude that many of the jellyfish galaxies seen in clusters likely formed via fast (~1- 2 Gyr), incremental, outside-in ram-pressure stripping during first infall into the cluster in highly radial orbits.