Miracle-dz/UniFAR-FTUs huggingface dataset:
Citizenship beyond Nationality: Immigrants’ Right to Vote across the World

are absent and there is a relative lack of consideration for class variation, given the predominantly (upper-) middle class focus. Politics, social class, and ‘‘work’’ may be of further importance for future research. The generational matrix—the guiding framework for the volume—is a construct that also merits critical reflection. To what extent is the experience of racial marginalization—and the reinforcement of ethnicity among Japanese American millennials—attributable to the wider socio-historical conditions of their time? The utility of generational analysis may rest in its revelation of aspects of the social life of a specific cohort—but the framework, as the editors clearly indicate, entails problems of narrowness and reification. Under the stated aim of serving as a call ‘‘for the revitalization of Japanese American studies,’’ Japanese American Millennials marks a collective effort to break new ground in the understudied experiences of a contemporary social group. In so doing, the volume engages questions of wider significance for race and ethnicity in the United States. This anthology will therefore recommend itself to scholars and students of Asian American studies and Japanese American studies, and also to those interested in contemporary debates and inquiry concerning immigration, race, and ethnicity in society.
Modelling of damage of a liquid-core microcapsule in simple shear flow until rupture

Abstract Capsules, composed of a liquid core protected by a thin deformable membrane, offer high-potential applications in many fields of industry such as bioengineering. One of their limitations comes from the absence of models of capsule damage and/or rupture when they are subjected to an external flow. To assess when rupture is initiated, we develop a fluid–structure interaction (FSI) numerical model of a capsule in Stokes flow that accounts for potential damage of the capsule membrane. We consider the framework of continuum damage mechanics and model the membrane with an isotropic brittle damage model, in which the membrane damage state depends on the history of loading. The FSI problem is solved by coupling the finite element method, to solve for the membrane deformation, with the boundary integral method, to solve for the inner and outer fluid flows. The model is applied to an initially spherical capsule subjected to a simple shear flow. Damage initiates at a critical value of the capillary number, ratio of the fluid viscous forces to the membrane elastic forces and rupture occurs at a higher capillary number, when it reaches a threshold value. The material parameters introduced in the damage model do not influence the mode of damage but only the values of the critical and threshold capillary numbers. When the capillary number is larger than the critical value, damage develops in the two symmetric central regions containing the vorticity axis. It is indeed in these regions that the internal tensions are the highest on the membrane.
On the nature of intermittency in a turbulent von Kármán flow

Abstract We have conducted an extensive study of the scaling properties of small scale turbulence using both numerical and experimental data of a flow in the same von Kármán geometry. We have computed the wavelet structure functions, and the structure functions of the vortical part of the flow and of the local energy transfers. We find that the latter obey a generalized extended scaling, similar to that already observed for the wavelet structure functions. We compute the multi-fractal spectra of all the structure functions and show that they all coincide with each other, providing a local refined hypothesis. We find that both areas of strong vorticity and strong local energy transfer are highly intermittent and are correlated. For most cases, the location of local maximum of the energy transfer is shifted with respect to the location of local maximum of the vorticity. We, however, observe a much stronger correlation between vorticity and local energy transfer in the shear layer, that may be an indication of a self-similar quasi-singular structure that may dominate the scaling properties of large order structure functions.
A three-dimensional small-deformation theory for electrohydrodynamics of dielectric drops

Abstract Electrohydrodynamics of drops is a classic fluid mechanical problem where deformations and microscale flows are generated by application of an external electric field. In weak fields, electric stresses acting on the drop surface drive quadrupolar flows inside and outside and cause the drop to adopt a steady axisymmetric shape. This phenomenon is best explained by the leaky-dielectric model under the premise that a net surface charge is present at the interface while the bulk fluids are electroneutral. In the case of dielectric drops, increasing the electric field beyond a critical value can cause the drop to start rotating spontaneously and assume a steady tilted shape. This symmetry-breaking phenomenon, called Quincke rotation, arises due to the action of the interfacial electric torque countering the viscous torque on the drop, giving rise to steady rotation in sufficiently strong fields. Here, we present a small-deformation theory for the electrohydrodynamics of dielectric drops for the complete Melcher–Taylor leaky-dielectric model in three dimensions. Our theory is valid in the limits of strong capillary forces and highly viscous drops and is able to capture the transition to Quincke rotation. A coupled set of nonlinear ordinary differential equations for the induced dipole moments and shape functions are derived whose solution matches well with experimental results in the appropriate small-deformation regime. Retention of both the straining and rotational components of the flow in the governing equation for charge transport enables us to perform a linear stability analysis and derive a criterion for the applied electric field strength that must be overcome for the onset of Quincke rotation of a viscous drop.
Just 2% of SARS-CoV-2-positive individuals carry 90% of the virus circulating in communities

We analyze data from the Fall 2020 pandemic response efforts at the University of Colorado Boulder (USA), where more than 72,500 saliva samples were tested for SARS-CoV-2 using quantitative RT-PCR. All samples were collected from individuals who reported no symptoms associated with COVID-19 on the day of collection. From these, 1,405 positive cases were identified. The distribution of viral loads within these asymptomatic individuals was indistinguishable from what has been previously reported in symptomatic individuals. Regardless of symptomatic status, approximately 50% of individuals who test positive for SARS-CoV-2 seem to be in non-infectious phases of the disease, based on having low viral loads in a range from which live virus has rarely been isolated. We find that, at any given time, just 2% of individuals carry 90% of the virions circulating within communities, serving as viral super-carriers and possibly also super-spreaders.
Experimental Evaluation of the Petrophysical Algorithm in an Integrated Flow Model

Abstract An experimental apparatus was designed to simultaneously measure fluid flow rates and high-frequency (ultrasonic) elastic wave velocities. The measured fluid production and elastic wave velocity data were compared to integrated flow model (IFM) calculations. An IFM is a flow simulator with a petrophysical model that can calculate seismic attributes using reservoir and fluid properties. The petrophysical algorithm is an extension of Gassmann's equation that lets moduli depend on effective pressure, porosity, and clay fraction. A new set of correlation coefficients for the petrophysical algorithm was obtained by matching high-frequency measurements.
Influence of Water Solubility, Side-Chain Degradability, and Side-Chain Structure on the Degradation of Phthalic Acid Esters under Methanogenic Conditions

Water solubility and the degradability of side chains estrifying phthalic acid are some of the factors that could influ ence the degradation of phthalic acid esters (PAEs). To assess the importance of these factors, the degradation of butyl 2-ethylhexyl phthalate (BEHP), bis(2-ethylhexyl) phthalate (DEHP), dibutyl phthalate (DBP), dihexyl phthalate (DHP), dioctyl phthalate (DOP), and didecyl phthalate (DDP) as well as the alcohols estrifying these PAEs was examined using a methanogenic butylbenzyl phthalate (BBP)-degrading enrichment culture. We also set out to determine whether the degradation of resistant PAEs could be stimulated by the addition of a PAE known to be degradable. The investigation strongly indicates that water solubility is a major factor limiting degradation of hydrophobic PAEs. In the study conducted, PAEs having high water solubility (DBP, BBP, BEHP, and DHP) were degraded, whereas those having low water solubility were not (DEHP, DOP, and DDP). The investigation also showed that all a.
Influence of Flight Ash Properties from Thermal Transformation of Sewage Sludge on Ordinary Concrete Parameters

Abstract Nowadays, the concrete is the most widely used composite material among those made by human and the second (after water) among all materials used by people. It is an ecological material, being made of local raw materials – aggregate, cement, water, admixtures and mineral additives − characterized by the lowest carbon trace. The paper presents results of investigations of the concretes of C20/25 class based on the cement CEM I 42.5R, pebble aggregate as well as fly ashes from thermal conversion of sewage sludge replacing 5, 10, 15 and 20% of the cement mass. In the course of experimental work, compressive strength measurements were made at two stages of curing and frost resistance F150. The collected research results made it possible to compare the properties of concretes produced with the ash from two treatment plants. The obtained results confirm possibility of manufacturing of the concretes modified by fly ash from combustion of municipal sewage sludge. The average compressive strength for the concrete containing 20% of ash from Kraków has been established at the level of 50.1 and 50.6 MPa after 28 and 56 days of curing, respectively and for ash from Warsaw at 42.6 and 45.7 MPa.
The average vertical mixing coefficient for the oceanic thermocline

The new estimate of the average vertical mixing coefficient for the oceanic thermocline, based on all GEOSECS tritium data, is 1.7 ± 0.2 cm 2 s -1 . DOI: 10.1111/j.1600-0889.1984. tb00243.x
The role of hydropower in South Asia’s energy future

ABSTRACT With rising energy demand in Asia, the high potential for hydropower development and the need for low-carbon energy development, hydropower would seem to have a significant role in South Asia’s energy future. However, the extent of hydropower development will depend on several risk factors, including the cost of alternative energy sources, the environmental sustainability of hydropower and social issues of equitable development. Using a risk-analysis framework, it is concluded that the future of hydropower will depend on how well policies and institutions manage the risks, facilitate efficient financial markets, and promote fair and friendly cross-border electricity trade.
Free, appropriate, public, and educational? Screen-schooling U.S. children with disabilities during the 2020 pandemic

I was born in 1969, the year Sesame Street debuted. I love and respect educational screen media. However, screens exist in environments that modify the effectiveness of screen-delivered education far more than I could have imagined pre-COVID-19, especially for children with disabilities. In the U.S., kids with disabilities were granted the right to a public education in the 1970s. The national shift to online instruction was a metaphorical time machine sending them back to the 1960s. My goal in this essay is to explain how even an extensively privileged white family headed by two COVID-free parents with health insurance, the economic security of tenure, the option to work from home, and home ownership in a district that loans a laptop to every student, still failed to adequately educate our own children with disabilities. Kids like ours whose parents have fewer options and resources may be receiving no education at all.
The Effect of Early Maternal Separation Combined With Adolescent Chronic Unpredictable Mild Stress on Behavior and Synaptic Plasticity in Adult Female Rats

Our aims were to evaluate the depression model of early maternal separation (MS) combined with adolescent chronic unpredictable mild stress (CUMS) in female adult SD rats to observe the behavior and the expressions of synaptic proteins in rats and to provide a reference for the screening of antidepressant drug activity. In our study, MS and CUMS were conducted to establish a dual stress model on female rats. Behavioral tests, including the sucrose preference test, open field test, and zero maze test, were used to detect depression-like and anxiety-like behavior of animals. Nissl staining was used to detect the number of neuronal cells in the hippocampus CA1 and DG regions of rats from each group. Synaptophysin (SYN), postsynaptic density-95 (PSD-95), and growth-associated protein-43 (GAP-43) expressions in the hippocampus were detected by western blot. Expression of the hippocampus SYN protein was further detected by immunohistochemistry. Rats in the MS+CUMS group presented more serious depression-like and anxiety-like behavior than in the MS group. Also, few Nissl bodies in the hippocampus CA1 and DG regions, less percentage of SYN-positive cells, and downregulated expressions of SYN, PSD-95, and GAP43 were found in the hippocampus of rats in MS+CUMS group. In conclusion, adult female rats that underwent MS and CUMS performed more critical depression-like and anxiety-like behaviors, and this process may be resulted from synaptic plasticity impairment.
A Natural Xenogeneic Endometrial Extracellular Matrix Hydrogel Toward Improving Current Human in vitro Models and Future in vivo Applications

Decellularization techniques support the creation of biocompatible extracellular matrix hydrogels, providing tissue-specific environments for both in vitro cell culture and in vivo tissue regeneration. We obtained endometrium derived from porcine decellularized uteri to create endometrial extracellular matrix (EndoECM) hydrogels. After decellularization and detergent removal, we investigated the physicochemical features of the EndoECM, including gelation kinetics, ultrastructure, and proteomic profile. The matrisome showed conservation of structural and tissue-specific components with low amounts of immunoreactive molecules. EndoECM supported in vitro culture of human endometrial cells in two- and three-dimensional conditions and improved proliferation of endometrial stem cells with respect to collagen and Matrigel. Further, we developed a three-dimensional endometrium-like co-culture system of epithelial and stromal cells from different origins. Endometrial co-cultures remained viable and showed significant remodeling. Finally, EndoECM was injected subcutaneously in immunocompetent mice in a preliminary study to test a possible hypoimmunogenic reaction. Biomimetic endometrial milieus offer new strategies in reproductive techniques and endometrial repair and our findings demonstrate that EndoECM has potential for in vitro endometrial culture and as treatment for endometrial pathologies.
A Review of Nervonic Acid Production in Plants: Prospects for the Genetic Engineering of High Nervonic Acid Cultivars Plants

Nervonic acid (NA) is a very-long-chain monounsaturated fatty acid that plays crucial roles in brain development and has attracted widespread research interest. The markets encouraged the development of a refined, NA-enriched plant oil as feedstocks for the needed further studies of NA biological functions to the end commercial application. Plant seed oils offer a renewable and environmentally friendly source of NA, but their industrial production is presently hindered by various factors. This review focuses on the NA biosynthesis and assembly, NA resources from plants, and the genetic engineering of NA biosynthesis in oil crops, discusses the factors that affect NA production in genetically engineered oil crops, and provides prospects for the application of NA and prospective trends in the engineering of NA. This review emphasizes the progress made toward various NA-related topics and explores the limitations and trends, thereby providing integrated and comprehensive insight into the nature of NA production mechanisms during genetic engineering. Furthermore, this report supports further work involving the manipulation of NA production through transgenic technologies and molecular breeding for the enhancement of crop nutritional quality or creation of plant biochemical factories to produce NA for use in nutraceutical, pharmaceutical, and chemical industries.
Pretending to Be Better Than They Are? Emotional Manipulation in Imprisoned Fraudsters

Fraud can cause severe financial losses and affect the physical and mental health of victims. This study aimed to explore the manipulative characteristics of fraudsters and their relationship with other psychological variables. Thirty-four fraudsters were selected from a medium-security prison in China, and thirty-one healthy participants were recruited online. Both groups completed an emotional face-recognition task and self-report measures assaying emotional manipulation, psychopathy, emotion recognition, and empathy. Results showed that imprisoned fraudsters had higher accuracy in identifying fear and surprise faces but lower accuracy in identifying happiness than controls (t = 5.26, p < 0.001; t = 2.38, p < 0.05; t = 3.75, p < 0.001). Significantly lower scores on non-prosocial factors on the Managing the Emotions of Others scale (MEOS) were found for imprisoned fraudsters, relative to controls (t = 3.21, p < 0.01). Imprisoned fraudsters had low scores in the assessment of psychopathy than the control group, especially Factor 1 (t = 2.04, p = 0.05). For empathy, imprisoned fraudsters had significantly higher scores in perspective-taking than controls (t = 2.03, p = 0.05). Correlation analyses revealed that psychopathic traits were positively correlated with non-prosocial factors in both groups. However, the relationships between emotional manipulation and emotional recognition and empathy were not consistent across the groups. The results suggest that fraudsters may pretend to be as prosocial as healthy controls, who had lower antisocial tendencies, normal empathy ability, and would like to manipulate others’ emotions positively during social interaction.
Improving the Odds in Advanced Breast Cancer With Combination Immunotherapy: Stepwise Addition of Vaccine, Immune Checkpoint Inhibitor, Chemotherapy, and HDAC Inhibitor in Advanced Stage Breast Cancer

Breast tumors commonly harbor low mutational burden, low PD-L1 expression, defective antigen processing/presentation, and an immunosuppressive tumor microenvironment (TME). In a malignancy mostly refractory to checkpoint blockade, there is an unmet clinical need for novel combination approaches that increase tumor immune infiltration and tumor control. Preclinical data have guided the development of this clinical trial combining 1) BN-Brachyury (a poxvirus vaccine platform encoding the tumor associated antigen brachyury), 2) bintrafusp alfa (a bifunctional protein composed of the extracellular domain of the TGF-βRII receptor (TGFβ “trap”) fused to a human IgG1 anti-PD-L1), 3), entinostat (a class I histone deacetylase inhibitor), and 4) T-DM1 (ado-trastuzumab emtansine, a standard of care antibody-drug conjugate targeting HER2). We hypothesize that this tetratherapy will induce a robust immune response against HER2+ breast cancer with improved response rates through 1) expanding tumor antigen-specific effector T cells, natural killer cells, and immunostimulatory dendritic cells, 2) improving antigen presentation, and 3) decreasing inhibitory cytokines, regulatory T cells, and myeloid-derived suppressor cells. In an orthotopic HER2+ murine breast cancer model, tetratherapy induced high levels of antigen-specific T cell responses, tumor CD8+ T cell/Treg ratio, and augmented the presence of IFNγ- or TNFα-producing CD8+ T cells and IFNγ/TNFα bifunctional CD8+ T cells with increased cytokine production. Similar effects were observed in tumor CD4+ effector T cells. Based on this data, a phase 1b clinical trial evaluating the stepwise addition of BN-Brachyury, bintrafusp alfa, T-DM1 and entinostat in advanced breast cancer was designed. Arm 1 (TNBC) receives BN-Brachyury + bintrafusp alfa. Arm 2 (HER2+) receives T-DM1 + BN-Brachyury + bintrafusp alfa. After safety is established in Arm 2, Arm 3 (HER2+) will receive T-DM1 + BN-Brachyury + bintrafusp alfa + entinostat. Reimaging will occur every 2 cycles (1 cycle = 21 days). Arms 2 and 3 undergo research biopsies at baseline and after 2 cycles to evaluate changes within the TME. Peripheral immune responses will be evaluated. Co-primary objectives are response rate and safety. All arms employ a safety assessment in the initial six patients and a 2-stage Simon design for clinical efficacy (Arm 1 if ≥ three responses of eight then expand to 13 patients; Arms 2 and 3 if ≥ four responses of 14 then expand to 19 patients per arm). Secondary objectives include progression-free survival and changes in tumor infiltrating lymphocytes. Exploratory analyses include changes in peripheral immune cells and cytokines. To our knowledge, the combination of a vaccine, an anti-PD-L1 antibody, entinostat, and T-DM1 has not been previously evaluated in the preclinical or clinical setting. This trial (NCT04296942) is open at the National Cancer Institute (Bethesda, MD).
The Relationship Between Big Five Personality and Social Well-Being of Chinese Residents: The Mediating Effect of Social Support

Previous studies have noted that personality traits are important predictors of well-being, but how big five personality influences social well-being is still unknown. This study aims to examine the link between big five personality and five dimensions of social well-being in the Chinese cultural context and whether social support can play the mediating effect in the process. This study included 1,658 participants from different communities in China, and regression analyses were conducted. Results revealed that five personality traits were significantly related to overall social well-being; extraversion was significantly related to social integration; agreeableness was positively related to all five dimensions of social well-being; conscientiousness was positively related to social actualization, social coherence, and social contribution; neuroticism was negatively related to social integration, social acceptance, social actualization, and social coherence; openness was positively related to social integration, social acceptance, social coherence, and social contribution. Social support plays mediating roles in the relationships between extraversion/agreeableness/conscientiousness/neuroticism/openness and social well-being, respectively.