Miracle-dz/UniFAR-FTUs huggingface dataset:
CDK4/6 Inhibitors in Pancreatobiliary Cancers: Opportunities and Challenges

Simple Summary Pancreatobiliary cancers are a group of malignancies affecting the pancreas and biliary tract and are among the cancers with the lowest survival rate. Current first-line treatments only offer a modest increase in overall survival, and there is an urgent need to develop new therapeutic strategies. Emerging evidence suggests cyclin-dependent kinase 4/6 (CDK4/6) inhibitors as an attractive therapeutic strategy for solid cancers, and here, we summarize the current knowledge and exploration of their therapeutic potential in the most common pancreatobilliary cancers, cholangiocarcinoma and pancreatic ductal adenocarcinoma. Abstract Existing treatment strategies for pancreatobiliary malignancies are limited. Nowadays, surgery is the only path to cure these types of cancer, but only a small number of patients present with resectable tumors at the time of diagnosis. The notoriously poor prognosis, lack of diverse treatment options associated with pancreaticobiliary cancers, and their resistance to current therapies reflect the urge for the development of novel therapeutic targets. Cyclin-dependent kinase 4/6 (CDK4/6) inhibitors have emerged as an attractive therapeutic strategy in a number of cancers since their approval for treatment in patients with ER+/HER- breast cancer in combination with antiestrogens. In this article, we discuss the therapeutic potential of CDK4/6 inhibitors in pancreatobiliary cancers, notably cholangiocarcinoma and pancreatic ductal adenocarcinoma.
Demographic and Psychosocial Predictors of Housing Security in Older Lesbian and Gay Australians

This study examined housing security among 679 lesbian women and gay men aged 60 years and older living in Australia. We examined a range of potential demographic and psychosocial predictors of whether participants felt that their housing situation was secure. Overall, most participants (89%) felt that their housing situation was secure. We found that the sense of housing security was greater among those who were younger, had people they felt they could depend on, had better self-rated health, and had fewer experiences of sexual orientation discrimination over the past year. In addition, housing security was greater among those who owned their own home and had no mortgage, compared with those who had a mortgage, were renting, or had some other living arrangement. No other demographic variables were significant predictors of housing security. These results can be useful in targeting groups that may be particularly vulnerable to a lack of housing security.
The Intracellular and Secreted Sides of Osteopontin and Their Putative Physiopathological Roles

Classically, osteopontin (OPN) has been described as a secreted glycophosprotein. Indeed, most data concerning its physiological and pathological roles are mainly related to the secreted OPN (sOPN). However, there are several instances in which intracellular OPN (iOPN) has been described, presenting some specific roles in distinct experimental models, such as in the immune system, cancer cells, and neurological disorders. We herein aimed to highlight and discuss some of these secreted and intracellular roles of OPN and their putative clinical and biological impacts. Moreover, by consolidating data from the OPN protein database, we also analyzed the occurrence of signal peptide (SP) sequences and putative subcellular localization, especially concerning currently known OPN splicing variants (OPN-SV). Comprehending the roles of OPN in its distinct cellular and tissue environments may provide data regarding the additional applications of this protein as biomarkers and targets for therapeutic purposes, besides further describing its pleiotropic roles.
Li I spectra in the 4.65-8.33 micron range: high-Lstates and oscillator strengths

Context. Infrared (IR) astronomy capacities have rapidly developed in recent years thanks to several ground- and space-based facilities. To take advantage of these capabilities efficiently, a large amount of atomic data (such as line wavenumber, excited-level energy values, and oscillator strengths) are needed. These data are incomplete, in particular, for lithium whose abundances are important for several astrophysical problems. Aims. No laboratory-measured spectra of Li I have been reported for wavelengths longward of 6.6 microns. We aim to find new Li I lines in the 4.65–8.33 microns range due to transitions between states with high orbital momentum (l ≥ 4) and to determine the excitation energies of these states. Methods. The Li I lines were studied using the time-resolved Fourier transform infrared spectroscopy of a plasma created by the laser ablation of a LiF target in a vacuum. The classification of the lines was performed by accounting for oscillator strengths (f -values) calculated using quantum defect theory (QDT). The adequacy of QDT for these calculations was checked by comparison with the available experimental and theoretical results. Results. We report four new Li I lines in the 900–2200 cm –1 range that allow us to extract the excitation energies of the 6g, 6h, and 7h states of Li I, which have not been measured before. We also provide a large list of QDT-calculated f -values for Li I in the range of 1–20 microns.
The Influence of Recruitment, Competence and Supervision on the Performance of School Operational Assistance Fund Managers

Abstract: Public services in the education sector are still unfinished homework in the Banggai Islands District. Various problems indicate the low competence of human resources owned by BOS fund managers. Changes and improvements to HR competencies are one of the focus points for bureaucratic reform that must be carried out by BOS fund managers, both at the regional and school levels. This study aimed to analyze how much influence HR recruitment and competence had on BOS fund management performance and how big HR recruitment and competence influenced BOS fund management performance moderated by supervision at the Education and Culture Office of the Banggai Islands Regency, Central Sulawesi Province. The research methodology used in this research is quantitative, with a total of 61 respondents. The data analysis method used in this study is SEM (Structural Equation Modeling) with the PLS (Partial Least Square) approach. The results showed a significant direct effect between recruitment and HR competency variables on BOS fund management performance and a significant indirect effect between recruitment and HR competency variables on BOS fund management performance moderated by supervision at the Education and Culture Office of the Banggai Islands Regency. Central Sulawesi Province. The supervision variable as a moderating variable can directly increase the influence between recruitment and competency variables on performance variables.
Multiple effects of consonant manner of articulation and intonation type on F0 in English

In this study we examine how consonant manner of articulation interacts with intonation type in shaping the F0 contours in English. Native speakers of American English read aloud words differing in vowel length, consonant manner of articulation and consonant position in word. They produced each word in either a statement or question carrier. F0 contours of their speech were extracted by measuring every complete vocal period. Preliminary results based on graphic analysis of three speakers’ data suggest that there are three distinct consonantal effects: F0 interruption due to devoicing, a large but brief (10–40 ms) F0 raising at the onset of voicing, and a smaller but longer‐lasting F0 raising throughout a large proportion of the preceding and following vowels. These effects appear to be imposed on a continuously changing F0 curve that is either rising‐falling or falling‐rising, depending on whether the carrier sentence is a statement or a question. Further analysis will test the hypothesis that these conti.
Symplectic Manifolds and Isomonodromic Deformations.

We study moduli spaces of meromorphic connections (with arbitrary order poles) over Riemann surfaces together with the corresponding spaces of monodromy data (involving Stokes matrices). Natural symplectic structures are found and described both explicitly and from an infinite dimensional viewpoint (generalising the Atiyah-Bott approach). This enables us to give an intrinsic symplectic description of the isomonodromic deformation equations of Jimbo, Miwa and Ueno, thereby putting the existing results for the six Painleve equations and Schlesinger's equations into a uniform framework.
Edgeworth Expansion of a Function of Sample Means

Many important statistics can be written as functions of sample means of vector variables. A fundamental contribution to the Edgeworth expansion for functions of sample means was made by Bhattacharya and Ghosh. In their work the crucial Cramer c-condition is assumed on the joint distribution of all the components of the vector variable. However, in many practical situations, only one or a few of the components satisfy (conditionally) this condition while the rest do not (such a case is referred to as satisfying the partial Cramer c-condition). The purpose of this paper is to establish Edgeworth expansions for functions of sample means when only the partial Cramer c-condition is satisfied.
On linear relations between roots of unity

In a recent paper I. J. Schoenberg [1] considered relations where the a v are rational integers and the ζ v are roots of unity. We may in (1) replace all negative coefficients a v by − a v replacing at the same time ζ v by −ζ v so that we may, if it is convenient, assume that all a v are positive. If we do this and arrange the ζ r so that their arguments do not decrease with v then (1) can, as suggested by Schoenberg (oral communication) be interpreted as a convex polygon with integral sides whose angles are rational when measured in degrees. Accordingly we shall call a relation (1) a polygon if all a v are non-negative. We shall call a polygon (1) k -sided if all a v are positive. The polygon is called degenerate if two of the ζ v are equal. Schoenberg calls these polygons polar rational polygons (abbreviated prp) because the vectors composing them have rational coordinates in their polar representations. Schoenberg showed that every prp can be obtained as a linear combination with integral positive or negative coefficients of regular p -gons where p is a prime.
Northern dwarf and low surface brightness galaxies. IV - The large-scale space distribution

Results are reported from a statistical analysis of published observational data on a sample of 860 northern dwarf and low-surface-brightness (D/LSB) galaxies with delta = 0 deg or greater and b between -40 and 40 deg, selected from the Uppsala General Catalogue of Galaxies (Nilson et al., 1973). The results are presented in extensive redshift/space maps, histograms, graphs and tables and characterized in detail. It is shown that the distribution of D/LSB galaxies closely resembles that of bright galaxies, apparently ruling out biased-star-formation models predicting a uniform distribution of D/LSBs. Although bright galaxies outside clusters are somewhat more clustered than the H I-rich D/LSBs, the latters' pairwise peculiar velocity (460 + or - 50 km/sec) is similar to that of the former. 39 refs.
ER-PM Junctions on GABAergic Interneurons Are Organized by Neuregulin 2/VAP Interactions and Regulated by NMDA Receptors

Neuregulins (NRGs) signal via ErbB receptors to regulate neural development, excitability, synaptic and network activity, and behaviors relevant to psychiatric disorders. Bidirectional signaling between NRG2/ErbB4 and NMDA receptors is thought to homeostatically regulate GABAergic interneurons in response to increased excitatory neurotransmission or elevated extracellular glutamate levels. Unprocessed proNRG2 forms discrete clusters on cell bodies and proximal dendrites that colocalize with the potassium channel Kv2.1 at specialized endoplasmic reticulum-plasma membrane (ER-PM) junctions, and NMDA receptor activation triggers rapid dissociation from ER-PM junctions and ectodomain shedding by ADAM10. Here, we elucidate the mechanistic basis of proNRG2 clustering at ER-PM junctions and its regulation by NMDA receptors. Importantly, we demonstrate that proNRG2 promotes the formation of ER-PM junctions by directly binding the ER-resident membrane tether VAP, like Kv2.1. The proNRG2 intracellular domain harbors two non-canonical, low-affinity sites that cooperatively mediate VAP binding. One of these is a cryptic and phosphorylation-dependent VAP binding motif that is dephosphorylated following NMDA receptor activation, thus revealing how excitatory neurotransmission promotes the dissociation of proNRG2 from ER-PM junctions. Therefore, proNRG2 and Kv2.1 can independently function as VAP-dependent organizers of neuronal ER-PM junctions. Based on these and prior studies, we propose that proNRG2 and Kv2.1 serve as co-regulated downstream effectors of NMDA receptors to homeostatically regulate GABAergic interneurons.
Experiments on the flow past spheres at very high Reynolds numbers

The present work is concerned with the flow past spheres in the Reynolds number range 5 × 104 [les ] Re [les ] 6 × 106. Results are reported for the case of a smooth surface. The total drag, the local static pressure and the local skin friction distribution were measured at a turbulence level of about 0·45%. The present results are compared with other available data as far as possible. Information is obtained from the local flow parameters on the positions of boundary-layer transition from laminar to turbulent flow and of boundary-layer separation. Finally the dependence of friction forces on Reynolds number is pointed out.
Some probability limit theorems with statistical applications

In fundamental papers Bernstein (3) and Loève(8) have proved central limit theorems for wide classes of dependent variables. Their theorems are stated in terms of conditional distributions. In the case of dn-dependent variables (see § 3) they assume the existence, as the ‘conditioning’ variates vary, of finite upper bounds for certain conditional absolute moments higher than the second. More recently, Hoeffding and Robbins (7) have proved central limit theorems for m-dependent variables with finite third absolute moments, and Moran(10) has given a direct generalization of the Lindeberg-Lévy theorem for stationary discrete linear scalar processes.
ES-YOLO: a new lightweight fire detection model

For the problems of fire detection models based on computer vision, such as long inference and training time, too many model parameters and low detection accuracy. We propose ES-YOLO, which can quickly and accurately detect flames and smoke. Firstly, the original YOLOv5s backbone network is replaced with EfficientNetV2, which reduces the computational complexity of the network and improves the detection accuracy. Secondly, replaces the CIoU loss function with SIoU, which speeds up the convergence of the model. Finally, 9-Mosaic data augmentation is designed to enrich the dataset. The experimental results on the PASCAL VOC2007 dataset demonstrate that the mAP@0.5 and recall of ESYOLO are 20% and 15% higher than that of YOLOv5s, the size of the model are compressed to 1/2 of that of YOLOv5s. ES-YOLO meets the requirements of lightweight and real-time detection.
Immunohistochemical Expression (IE) of Oestrogen Receptors in the Intestines of Prepubertal Gilts Exposed to Zearalenone

This study was conducted to determine if a low monotonic dose of zearalenone (ZEN) affects the immunohistochemical expression (IE) of oestrogen receptor alpha (ERα) and oestrogen receptor beta (ERβ) in the intestines of sexually immature gilts. Group C (control group; n = 18) gilts were given a placebo. Group E (experimental group; n = 18) gilts were dosed orally with 40 μg ZEN /kg body weight (BW), each day before morning feeding. Samples of intestinal tissue were collected post-mortem six times. The samples were stained to analyse the IE of ERα and Erβ in the scanned slides. The strongest response was observed in ERα in the duodenum (90.387—average % of cells with ERα expression) and in ERβ in the descending colon (84.329—average % of cells with ERβ expression); the opposite response was recorded in the caecum (2.484—average % of cells with ERα expression) and the ascending colon (2.448—average % of cells with ERα expression); on the first two dates of exposure, the digestive tract had to adapt to ZEN in feed. The results of this study, supported by a mechanistic interpretation of previous research findings, suggest that ZEN performs numerous functions in the digestive tract.
Comparison of Negative Pressure Wound Therapy (NPWT) and Classical Wet to Moist Dressing (WtM) in the Treatment of Complicated Extremity Wounds in Children

Treating complicated wounds in the pediatric population using traditional wet to moist wound dressing methods is not always appropriate due to the frequent need to change dressings daily or even a number of times a day, causing distress to the patient. Topical negative pressure is a method that allows for fewer dressings and provides localized benefits, thus accelerating wound healing. The merits of this therapy have been proven in studies on adults, but research on the pediatric population is scarce. Here we intend to present the results of negative pressure wound therapy (NPWT) on 34 pediatric patients (study group) and compare them with 24 patients (control group) treated with the traditional wet to moist dressing for complicated wounds. The results show that topical negative pressure wound therapy is a safe method that downgrades a wound from a complicated to a simple one and allows definitive coverage using a simpler technique with fewer wound dressings. The scars of the patients in the study group exhibited a better result on a visual scar scale. The patients in the control group had a shorter hospital stay. Based on the recorded results, we were able to make treatment recommendations.
Electron impact excitation rates for transitions in beryllium-like P XII, S XIII, CI XIV, Ar XV and K XVI

Electron excitation rates for the Be-like ions Ne VII, Si XI and Ca XVII calculated with the R-matrix code are used to interpolate data for all transitions amongst the 2s2 1S, 2s2p 3P, 1P, 2p2 3P, 1D and 1S levels in P XII, S XIII, Cl XIV, Ar XV and K XVI. Results are presented in the form of polynomial fits in log Te to the effective collision strengths (γ) for each transition. These fits should lead to results accurate to approximately ± 10%, and are applicable over a temperature range of log Tmax ± 0.8 dex, where Tmax is the temperature of maximum fractional abundance in ionisation equilibrium of the relevant species. The present data for Ar XV are significantly different from the earlier distorted wave calculations of Bhatia et al.
Inhibition of return (IOR) meets stimulus-response (S-R) binding: Manually responding to central arrow targets is driven by S-R binding, not IOR

ABSTRACT Localizing targets repeating or changing their position typically leads to a benefit for location changes, that is, inhibition of return (IOR). Yet, IOR is mostly absent when sequentially responding to arrows pointing to the left or right. Previous research suggested that responding to central arrow targets resembles a discrimination response. For the latter, action control theories expect the modulation of response repetitions and changes by task-irrelevant feature repetitions and changes (e.g., colour), caused by stimulus-response (S-R) binding – a modulation typically absent in localization performance. In the current study, participants gave left and right responses to peripheral targets repeating or changing their position, and to central arrow targets repeating or changing their pointing direction. Targets could repeat or change their colour. For central targets, responses were heavily modulated by colour repetitions and changes, suggesting S-R binding. No S-R binding, but only IOR was found for peripheral targets. Analysis of reaction time percentiles suggested that this pattern was not caused by fast response execution. These results show that S-R binding approaches allow to explain effects typically discussed in the context of attentional orienting, highlighting the similarities of two research strands working in parallel for years without much of exchange.
Temporal evolution of chromospheric downflows

At the footpoints of loops spanning a site of flux emergence, earlier investigated in the papers by Solanki et al. (2003) and Lagg et al. (2004), we find large redshifts in the He 1083 nm line coexisting with an almost unshifted component. The speed associated with these redshifts reaches values as high as 40 km/s. We interpret these downflows in the context of several models: the free-fall downflow of matter along vertical field lines (Schmidt et al. 2000), the redshift by downward propagating acoustic waves (Hansteen 1993) and the motion of condensation regions to either side of loop footpoints (Müller et al. 2003). We present the temporal evolution of these redshifts and reconstruct the magnetic field vector in these regions for both the redshifted and the unshifted atmospheric component.To search for other articles by the author(s) go to: http://adsabs.harvard. edu/abstract_service. html
Absolute Pitch Identification: Effects of Timbre and Pitch Region

Pitch identification by absolute-pitch (AP) possessors was tested with three different timbres. Twelve notes per octave in the equally tempered chromatic scale were presented randomly over a seven-octave range. AP subjects identified the note quite accurately but showed a considerable number of octave errors, indicating that they indeed responded primarily to pitch classes. By contrast, subjects lacking AP gave widely scattered responses, indicating that they could not perceive pitch classes at all but responded solely on the basis of the approximate pitch region (pitch height). The performance of AP subjects was best for piano tones and worst for pure tones, and responses were most accurate in the middle region of the musical pitch range. Of 12 pitch classes, white-key notes on a musical keyboard (diatonic tones in the C major scale) tended to be identified more correctly and rapidly than were black-key notes (nondiatonic tones in the C major scale). All of the AP subjects had received training on the piano since a young age. It is suggested that AP can be acquired through such early musical experience.
Single-shot carrier-envelope-phase-tagged ion-momentum imaging of nonsequential double ionization of argon in intense 4-fs laser fields

Single-shot carrier-envelope-phase (CEP) tagging is combined with a reaction mircoscope (REMI) to investigate CEP-dependent processes in atoms. Excellent experimental stability and data acquisition longevity are achieved. Using this approach, we study the CEP effects for nonsequential double ionization of argon in 4-fs laser fields at 750 nm and an intensity of 1.6x10{sup 14} W/cm{sup 2}. The Ar{sup 2+} ionization yield shows a pronounced CEP dependence which compares well with recent theoretical predictions employing quantitative rescattering theory [S. Micheau et al., Phys. Rev. A 79, 013417 (2009)]. Furthermore, we find strong CEP influences on the Ar{sup 2+} momentum spectra along the laser polarization axis.