Miracle-dz/UniFAR-FTUs huggingface dataset:
Enhanced Tropospheric Wave Forcing of Two Anticyclones in the Prephase of the January 2009 Major Stratospheric Sudden Warming Event

AbstractTropospheric forcing of planetary wavenumber 2 is examined in the prephase of the major stratospheric sudden warming event in January 2009 (MSSW 2009). Because of a huge increase in Eliassen–Palm fluxes induced mainly by wavenumber 2, easterly angular momentum is transported into the Arctic stratosphere, deposited, and then decelerates the polar night jet. In agreement with earlier studies, the results reveal that the strongest eddy heat fluxes, associated with wavenumber 2, occur at 100 hPa during the prephase of MSSW 2009 in ERA-Interim. In addition, moderate conditions of the cold phase of ENSO (La Nina) contribute to the eddy heat flux anomaly. It is shown that enhanced tropospheric wave forcing over Alaska and Scandinavia is caused by tropical processes in two ways. First, in a climatological sense, La Nina contributes to an enhanced anticyclonic flow over both regions. Second, the Madden–Julian oscillation (MJO) has an indirect influence on the Alaskan ridge by enhancing eddy activity over t.
Oxidative Biomarkers Associated with the Pulmonary Manifestation of Post-COVID-19 Complications

Introduction: The role of mitochondria in post coronavirus disease 2019 (post-COVID-19) complications is unclear, especially in the long-term pulmonary complications. This study aims to investigate the association between post-COVID-19 pulmonary complications and mitochondrial regulatory proteins in the context of oxidative stress. Methodology: Patients who had recovered from COVID-19 were enrolled. According to the evidence of persistent interstitial lung lesions on computed tomography (CT), patients were divided into a long-term pulmonary complications group (P(+)) and a control group without long-term pulmonary complications (P(−)). We randomly selected 80 patients for investigation (40 subjects for each group). Biomarkers levels were determined by enzyme-linked immunosorbent assay (ELISA). Results: The serum concentrations of mitochondrial regulatory proteins were significantly higher in the P(+) group, including PTEN-induced kinase 1 (PINK1): 1.62 [1.02–2.29] ng/mL vs. 1.34 [0.94–1.74] ng/mL (p = 0.046); Dynamin-1-like protein (DNM1L): 1.6 [0.9–2.4] ng/mL IQR vs. 0.9 [0.5–1.6] ng/mL (p = 0.004); and Mitofusin-2 (MFN2): 0.3 [0.2–0.5] ng/mL vs. 0.2 [0.1–0.3] ng/mL IQR (p = 0.001). Patients from the P(+) group also had higher serum levels of chemokine ligand 18 (PARC, CCL18), IL-6, and tumour necrosis factor-alpha (TNF-α) cytokines than the P(−) group. The concentration of interferon alpha (IFN-α) was decreased in the P(+) group. Furthermore, we observed statistically significant correlations between the advanced glycation end product (sRAGE) and TNF-α (Pearson’s factor R = 0.637; p < 0.001) and between serum levels of DNM1L and IFN-α (Pearson’s factor R = 0.501; p = 0.002) in P(+) patients. Conclusions: Elevated concentrations of mitochondrial biomarkers in post-COVID-19 patients with long-term pulmonary complications indicate their possible role in the pathobiology of COVID-19 pulmonary sequelae. Oxidative stress is associated with the immune response and inflammation after COVID-19. TNF-α could be a promising biomarker for predicting pulmonary complications and may be a potential target for therapeutic intervention in patients with post-COVID-19 complications.
Production of photonic nanojets by using pupil-masked 3D dielectric cuboid

Photonic nanojets can be created via plane wave irradiation of multi-shaped mesoscale dielectric particles, and a waist of full-width at half-maximum (FWHM) smaller than the diffraction limit can be achieved in this process. In this paper, photonic nanojet produced by a pupil-masked 3D dielectric cuboid lens is numerically investigated under the irradiation of 532 nm wavelength plane wave. It is found that a pupil-masked cuboid lens is not only able to produce photonic nanojets with shorter FWHMs, but also increase its maximal intensity at certain masking ratios on the receiving surface. This phenomenon is different from the result of the spherical-lens reported in previous publications, and is attributed to the convergence of power flow and near-field numerical aperture (NA) increase after analysis of simulated power flow diagrams.
Rapid Screening of Microalgae as Potential Sources of Natural Antioxidants

In order to rapidly screen microalgae species as feedstocks for antioxidants, extracts were obtained from 16 microalgae strains (under 11 genera, 7 classes) using two methods: a one-step extraction with ethanol/water and a three-step fractionating procedure using hexane, ethylacetate, and water successively. Measuring the total phenol content (TPC), total carotenoid content (TCC), and antioxidant activity of the extracts, indicating TPC and TCC, played an important role in determining the antioxidant activity of the microalgae. A weighted scoring system was used to evaluate the antioxidant activity, and the scores of microalgal samples from two extraction methods were calculated using the same system. Among the investigated microalgae, Euglena gracilis SCSIO-46781 had the highest antioxidant score, contributing to high TPC and TCC, followed by Arthrospira platensis SCSIO-44012, Nannochloropsis sp. SCSIO-45224, Phaeodactylum tricornutum SCSIO-45120, and Nannochloropsis sp. SCSIO-45006, respectively. Additionally, the above-mentioned five strains are currently being applied in commercial production, indicating this system could be effective not only for screening microalgal antioxidants, but also for screening microalgal species/strains with strong adaptation to environmental stress, which is a critical trait for their commercial cultivation.
The Impact of the No Jab No Play and No Jab No Pay Legislation in Australia: A Scoping Review

Australia has a long history of population-based immunisation programs including legislations. This paper reports on a review of evaluations of the impact of the federal No Jab No Pay (NJNPay) and state implemented No Jab No Play (NJNPlay) legislations on childhood immunisation coverage and related parental attitudes. Five databases were searched for peer-review papers (Medline (Ovid); Scopus; PsycInfo; ProQuest; and CINAHL). Additional searches were conducted in Google Scholar and Informit (Australian databases) for grey literature. Studies were included if they evaluated the impact of the Australian NJNPay and/or NJNPlay legislations. Ten evaluations were included: nine peer-review studies and one government report. Two studies specifically evaluated NJNPlay, five evaluated NJNPay, and three evaluated both legislations. Findings show small but gradual and significant increases in full coverage and increases in catch-up vaccination after the implementation of the legislations. Full coverage was lowest for lower and higher socio-economic groups. Mandates are influential in encouraging vaccination; however, inequities may exist for lower income families who are reliant on financial incentives and the need to enrol their children in early childhood centres. Vaccine refusal and hesitancy was more evident among higher income parents while practical barriers were more likely to impact lower income families. Interventions to address access and vaccine hesitancy will support these legislations.
The Composite TiO2–CuOx Layers Formed by Electrophoretic Method for CO2 Gas Photoreduction

This study demonstrates the ability to control the properties of TiO2–CuOx composite layers for photocatalytic applications by using a simple electrophoretic deposition method from isopropanol-based suspension. To obtain uniform layers with a controlled composition, the surfactant sodium lauryl sulfate was used, which influenced the electrophoretic mobility of the particles and the morphology of the deposited layers. The TiO2–CuOx composite layers with different CuOx contents (1.5, 5.5, and 11 wt.%) were obtained. It is shown that the optical band gap measured by UV–VIS–NIR diffuse reflectance spectra. When CuOx is added to TiO2, two absorption edges corresponding to TiO2 and CuOx are observed, indicating a broadening of the photosensitivity range of the material relative to pure TiO2. An open-circuit potential study shows that by changing the amount of CuOx in the composite material, one can control the ratio of free charge carriers (n and p) and, therefore, the catalytic properties of the material. As a result, the TiO2–CuOx composite layers have enhanced photocatalytic activity compared to the pure TiO2 layer: methanol yield grows with increasing CuOx content during CO2 photoreduction.
The Effect of Hormonal Contraception Use on Ovarian Reserve Markers and the Uptake of Assisted Reproductive Technology in Individuals Seeking an Infertility Evaluation

Background and objective The effects of hormonal contraception (HC) use on ovarian reserve (OR) markers in individuals seeking an infertility evaluation and the success of assisted reproductive technology (ART) warrant further investigation. Therefore, the aim of this study was to determine if women seeking an evaluation for unexplained infertility who used long-term (≥2 years) HC have lower ovarian reserve (OR) markers and higher uptake of ART compared to short-term (<2 years) or never HC users. Methods We performed a cross-sectional patient survey involving a retrospective medical chart review of patients seeking an evaluation for unexplained infertility at the University of Colorado Advanced Reproductive Medicine (CU ARM) clinic. Results Most participants (87%; 107/123) reported a history of HC use with 98 (79.7%) reporting long-term continuous use for two or more years. Median OR markers were similar between long-term and short-term/never HC users [anti-Müllerian hormone (AMH): 2.4 vs. 3.2, p=0.20; antral follicle count (AFC): 18 vs. 26, p=0.10; follicle-stimulating hormone (FSH): 7.6 vs. 6.3, p=0.26] and remained so after adjusting for age and diagnosis of polycystic ovarian syndrome (PCOS) or primary ovarian insufficiency (POI) in linear regression models. However, among HC users aged less than 30 years (n=9), those who had discontinued HC between two and three years prior to the assessment of their OR markers had a 6.20 ng/mL increase in AMH level compared to those who had discontinued HC less than two years prior to the assessment (p=0.02). Additionally, there was a marginally increased use of ART overall among long-term HC users compared to short-term/never HC users (64.3% vs. 44.0%, p=0.06), specifically in the use of in vitro fertilization (IVF) (58.7% vs. 18.2%, p=0.01). Among long-term HC users, ovulation induction was less likely to result in live birth compared to short-term/never HC users (8.9% vs. 62.5%, p<0.001); however, after adjusting for age, PCOS, POI, and type of ART used, there was no difference in the odds of live birth after ART between long-term HC users and short-term/never users. Conclusion While long-term HC users report increased use of ART, in particular IVF, the overall conception rates and live birth outcomes among ART users do not appear to be significantly affected by a history of long-term HC use.
EFFECT OF FLY ASH, LIME AND CHEMICAL FERTILIZERS ON SOIL PHYSICO-CHEMICAL PROPERTIES AND GROWTH OF LENTIL

Fly ash (FA), a byproduct of coal combustion in thermal power plants, has been considered as a problematic solid waste and its safe disposal is a cause of concern. Several studies proposed that FA can be used as a soil additive; however, its effect on physico chemical properties of soil and growth of lentil (cv. Malviya Viswanath) to fly ash (FA) application in conjunction with lime and chemical fertilizers was studied in a pot experiment during winter 2020 in acid soil of Rajgarh block. Application of fly ash at higher dose in combination with lime amended the acidic condition of soil, whereas increased the salt concentration in soil. At higher level, when fly ash was applied to soil, it improved the physical properties of soil but declined the organic carbon content in soil. The application of fly ash @ 80% FD in conjunction with lime @ 20%LD and 100% RDF was more beneficial for the growth performance of lentil than the unamended soil
Concept Maps as a Resource to Enhance Teaching and Learning of Mathematics at Senior Secondary Level

Research has identified conceptual understanding as central to students’ mathematics comprehension. However, limited research is available to help teachers link mathematics concepts from junior to senior subjects during teaching and learning in Queensland. This mixed methods study is underpinned by constructivism. It explores teachers’ perceptions on how visual representations such as concept maps that link junior concepts (years 7 to 10) to senior concepts (year 11 and 12) can enhance the teaching and learning of conceptual knowledge at senior secondary mathematics. Surveys that include Likert scale items and open-ended questions were conducted with sixteen senior secondary mathematics teachers. To gain deeper understanding, eight semi-structured interviews were also conducted. Results show teachers hold the perception that when concept maps are used to link junior (years 7 to 10) to secondary concepts (year 11 and 12) they can be a resource that enhances conceptual knowledge, consolidation, and assessment of students’ mathematical knowledge. The role of visual representations in mathematics teaching and learning that is enhanced by concept maps is an area that needs more attention to help improve students’ participation and achievement.
Optimal solution to the multinomial selection problem for two alternatives

ABSTRACT The multinomial selection problem is to find a stopping policy for repeated independent trials, each of which reports a winner among competing alternatives that has low expected cost and high probability of correct selection (PCS) of the best alternative. In 1959, Bechhofer, Elmaghraby, and Morse formulated the problem as minimizing the worst-case expected number of trials, subject to a lower bound on PCS and upper bound on the maximum number of trials, over all probability vectors outside an indifference zone. For the case of two alternatives, we prove that if one employs a particular probability vector known as the slippage configuration, then a linear program always finds an optimal stopping policy.
A trial wavefunction approach to the frustrated square-lattice Heisenberg model

Models of interacting quantum spins have contributed significantly to our understanding of magnetism. The Heisenberg model on square lattice, which exhibits semiclassical Néel order, is one of the canonical models. However, with frustration introduced by competing interactions, the system becomes computationally intractable. Exotic quantum phases that have no magnetic long range order may be present due to the frustration. The quantum phases do not have any classical analogue, and a valence bond crystal state with translational and/or rotational symmetry breaking as well as a quantum spin liquid state have been proposed as potential candidates. We construct several trial wavefunctions in the resonating valence bond basis and apply large-scale unbiased calculations to examine the possible descriptions of the ground state in the strongly frustrated region. An analytical master equation is also proposed to provide an approximate solution for the valence bond states. Our numerical and analytical studies suggest that the frustrated ground state exhibits a one-dimensional-like behaviour.
Looking to the Future of the Role of Macrophages and Extracellular Vesicles in Neuroinflammation in ALS

Neuroinflammation is a common pathological feature of amyotrophic lateral sclerosis (ALS). Although scientific evidence to date does not allow defining neuroinflammation as an ALS trigger, its role in exacerbating motor neuron (MNs) degeneration and disease progression is attracting research interest. Activated CNS (Central Nervous System) glial cells, proinflammatory peripheral and infiltrated T lymphocytes and monocytes/macrophages, as well as the immunoreactive molecules they release, represent the active players for the role of immune dysregulation enhancing neuroinflammation. The crosstalk between the peripheral and CNS immune cells significantly correlates with the survival of ALS patients since the modification of peripheral macrophages can downregulate inflammation at the periphery along the nerves and in the CNS. As putative vehicles for misfolded protein and inflammatory mediators between cells, extracellular vesicles (EVs) have also drawn particular attention in the field of ALS. Both CNS and peripheral immune cells release EVs, which are able to modulate the behavior of neighboring recipient cells; unfortunately, the mechanisms involved in EVs-mediated communication in neuroinflammation remain unclear. This review aims to synthesize the current literature regarding EV-mediated cell-to-cell communication in the brain under ALS, with a particular point of view on the role of peripheral macrophages in responding to inflammation to understand the biological process and exploit it for ALS management.
Beyond Broca’s and Wernicke’s: Functional Mapping of Ancillary Language Centers Prior to Brain Tumor Surgery

Functional MRI is a well-established tool used for pre-surgical planning to help the neurosurgeon have a roadmap of critical functional areas that should be avoided, if possible, during surgery to minimize morbidity for patients with brain tumors (though this also has applications for surgical resection of epileptogenic tissue and vascular lesions). This article reviews the locations of secondary language centers within the brain along with imaging findings to help improve our confidence in our knowledge on language lateralization. Brief overviews of these language centers and their contributions to the language networks will be discussed. These language centers include primary language centers of “Broca’s Area” and “Wernicke’s Area”. However, there are multiple secondary language centers such as the dorsal lateral prefrontal cortex (DLPFC), frontal eye fields, pre- supplemental motor area (pre-SMA), Basal Temporal Language Area (BTLA), along with other areas of activation. Knowing these foci helps to increase self-assurance when discussing the nature of laterality with the neurosurgeon. By knowing secondary language centers for language lateralization, via fMRI, one can feel confident on providing neurosurgeon colleagues with appropriate information on the laterality of language in preparation for surgery.
The association between teacher–student relationships and school engagement: an investigation of gender differences

Abstract This study examined gender differences in the associations among teacher–student relationships and three types of school engagement (i.e. behavioural engagement, emotional engagement, and cognitive engagement) among elementary students by using Multi-Group Structural Equation Modelling (MGSEM). For both boys and girls, negative teacher–student relationships (i.e. Conflict) had a stronger association with their school engagement than did positive teacher–student relationships (i.e. Closeness). However, several salient gender discrepancies were found. Specifically, Conflict had a stronger relation with girls’ emotional engagement than it did with boys’ emotional engagement. Girls’ cognitive engagement had no significant association with their teacher–student relationship, while boys’ cognitive engagement was predicted by both Closeness and Conflict. Theoretical and practical implications were discussed.
Socio-Demographic, Clinical, and Mortality Differences between HIV-Infected and HIV/HTLV-1 Co-Infected Patients in Peru

Background and aims: In Peru, the estimated prevalence of human immunodeficiency virus (HIV) and human T-lymphotropic virus-1 (HTLV-1) co-infection has been reported to be as high as 18%. Despite the endemicity of HTLV-1 in Peru, few studies have assessed the impact of HIV/HTLV-1 co-infection. Our study compared socio-demographic and clinical characteristics, and mortality rates between HIV-infected and HIV/HTLV-1 co-infected patients. Methods: We reviewed the medical records of patients aged 18 years and older belonging to the HIV and HTLV-1 cohorts in Lima during a 30-year period: 1989–2019. Each HIV/HTLV-1 co-infected patient was randomly matched with two HIV-infected patients with similar characteristics (same sex, age ± 5 years, and same year of HIV diagnosis). Allegedly co-infected patients without a confirmatory diagnosis of HIV and HTLV-1 were excluded. Most of the patients in the HIV-infected group did not have a negative test result for HTLV-1 infection, so we used two probabilistic sensitivity analysis models to correct for potential HTLV-1 exposure misclassification bias in the group of HIV-infected patients. Results: Of 162 patients enrolled, 54 were HIV/HTLV-1 co-infected and 108 were HIV-infected. The median age was 42 years (IQR = 34–51 years) and the majority were male (61.1%), single (44.4%), heterosexual (71%), born in Lima (58%), educated at the secondary school level (55.6%), and receiving antiretroviral treatment (91.4%). HIV/HTLV-1 co-infection was associated with an increased risk of death (HR: 11.8; 95% CI: 1.55–89.00; p = 0.017) while antiretroviral treatment was associated with a decreased risk of death (HR: 0.03; 95% CI: 0.003–0.25; p = 0.001). The overall mortality rate was 13.6 per 100 persons and the survival time for co-infected patients (median = 14.19 years) was significantly shorter than that of HIV-infected patients (median = 23.83 years) (p < 0.001). Conclusions: HIV/HTLV-1 co-infected patients had a significantly shorter survival time compared to HIV-infected patients, suggesting that the immune alterations caused by HTLV-1 in CD4 cell count may have contributed to late initiation of antiretroviral treatment and prophylaxis against opportunistic infections over the decades, and thus reducing their benefits in these patients.