Miracle-dz/UniFAR-FTUs huggingface dataset:
Autonomous Asteroid Characterization through Nanosatellite Swarming

This paper develops a novel algorithmic framework for autonomous asteroid characterization for the Autonomous Nanosatellite Swarming (ANS) mission concept. There is significant interest in asteroids as evidenced by multiple completed and ongoing asteroid missions. However, these missions heavily rely on human oversight and Earth-based resources such as the NASA Deep Space Network. Such an approach is not sustainable in the long term due to cost and oversubscribed Earth-based resources. Furthermore, these missions typically utilize a single spacecraft that is slow to adapt to its environment due to light time delay and gaps in communication with the Earth. In contrast, ANS comprises multiple small spacecraft that operate autonomously after a brief ground-in-the-loop initialization. The spacecraft are equipped with low size, weight, power, and cost (SWaP-C) avionics including star trackers, short-range cameras, radio-frequency intersatellite links, and chip scale atomic clocks. The algorithmic framework developed in this paper utilizes the intersatellite links and images of the asteroid to simultaneously estimate the spacecraft states as well as the asteroid gravity field, shape, and rotational motion. This class of estimation problem is defined in this paper as simultaneous navigation and characterization (SNAC), which is a superset of simultaneous localization and mapping. The ANS SNAC framework consists of three novel modules: 1) multi-agent optical landmark tracking and 3D point reconstruction using stereovision, 2) state estimation through a computationally efficient and robust unscented Kalman filter, and 3) reconstruction of a global spherical harmonic shape model by leveraging a priori knowledge of the shape properties of small celestial bodies. This new framework is validated through the numerical simulation of three spacecraft orbiting the asteroid 433 Eros. The simulation results demonstrate that the proposed architecture provides autonomous and accurate SNAC in a safe manner without any a priori shape model and using only low SWaP-C avionics.
Assessment of genetic variability, heritability, genetic advance and correlation analysis among fruit-yield components in tomato inter-varietal hybrids

Tomato is one of the most important vegetable crops grown in India. We aimed to investigate the genetic variability, heritability, genetic advance, and correlation analysis for eleven yield and quality attributes. High heritability coupled with genetic advance was found for pericarp thickness, plant height, number of fruits per cluster, fruit length and fruit yield per hectare. Correlation analyses have been successful tools in developing selection criteria. Since increased fruit yield is an important goal in our tomato hybrid breeding program, we used correlation and path-coefficient analyses on fruit yield data. Fruit length, fruit width, chlorophyll content, pericarp thickness and number of seeds per fruit had a significant positive association with fruit yield quintal per hectare at both phenotypic and genotypic levels. Thus, selection for these characters could be considered as important selection criteria in improving hybrid tomato for high fruit yield per hectare.
Genotypic and Phenotypic Characterization, Antibiotic Resistance and Virulence Patterns of Staphylococcus aureus Isolated form Goat Mastitis

Objective: To determine the phenotypic and genotypic characterization of the virulence and antimicrobial susceptibility of S. aureus. Design: Descriptive study Samples:175 raw goat milk samples Procedures: A total of 87 S. aureus strains was isolated from goat with mastitis in north-west cost of Egypt. PCR technique was used to detect genes coding some virulence and antimicrobial properties while phenotypic antimicrobial susceptibility was determined by the disc diffusion method. Results: Most S. aureus isolates were resistant to amoxycillin (89.7%), penicillin G (88.5%), and ampicillin (86%) while were less resistant to other members of β-lactam group as cefoxitin (17.2%) and ceftriaxone (10.3%). The lowest resistant rates were toward fluroquinolone group members; ciprofloxacin, levofloxacin and ofloxacin in rates 1.2%, 2.3% and 4.5%, respectively. Tetracycline showed the highest level of phenotypic resistance (34.6%) and prevalence of a tetK gene (39.1%). The virulence factors, spa and coa exhibited prevalence rate of 6.9% and 8%, respectively with significant relationship between them. Conclusion and Clinical relevance: The problem of antimicrobial resistance needs strict measures to limit the indiscriminate use of antibiotics and concerted research efforts to limit the spread of resistant bacteria, which will negatively affect human health and control of the infectious diseases in both humans and animals.
Implications of irrigation water quality in tropical farms

BACKGROUND AND OBJECTIVES: Irrigation system water quality is a complex issue that involves the combined effects of various surface water management parameters. Monitoring of irrigation water quality is essential for the sustainability of crop production and productivity. The department of Sucre, in northern Colombia, is predominantly a ranching and agricultural region where agriculture is the main source for livelihoods. The purpose of this study was to assess the physicochemical quality of surface water in irrigation systems at 141 farms.METHODS: To this end, 141 water samples were taken to determine 22 physicochemical parameters. All in-situ measurements and laboratory analysis were performed using standard methods. The results obtained were compared with the international standards proposed by the United Nations’ Food and Agriculture Organization and the World Health Organization. Salinity and sodicity were measured using the irrigation water classification diagram, and the level of correlation between the 22 variables was assessed by means of correlation analysis.FINDINGS: The results obtained indicate that based on the measured parameters, the water is classified as appropriate for use in irrigation systems. The maximum and minimum pH values were 9.32 and 4.40, respectively; the maximum and minimum values of electrical conductivity were 669 and 19.80 µS/cm respectively; the maximum and minimum values of total dissolved solids were 478 and 11.80 mg/L respectively, and the maximum and minimum values of the sodium adsorption ratio were 1.72 and 0.01 mEq/L, respectively. CONCLUSION: Cation and anion concentrations were within the limits allowed by the Food and Agriculture Organization and the WHO. According to the irrigation water classification diagram, the waters were classified as C1S1 and C2S1, which implies that there are no restrictions for their use in irrigation systems, water type (I) and type (II).
An epigenomic landscape of cervical intraepithelial neoplasia and cervical cancer using single‐base resolution methylome and hydroxymethylome

Abstract Background Cervical cancer (CC) is the second leading cause of cancer death among women worldwide. Epigenetic regulation of gene expression through DNA methylation and hydroxymethylation plays a pivotal role during tumorigenesis. In this study, to analyze the epigenomic landscape and identify potential biomarkers for CCs, we selected a series of samples from normal to cervical intra‐epithelial neoplasia (CINs) to CCs and performed an integrative analysis of whole‐genome bisulfite sequencing (WGBS‐seq), oxidative WGBS, RNA‐seq, and external histone modifications profiling data. Results In the development and progression of CC, there were genome‐wide hypo‐methylation and hypo‐hydroxymethylation, accompanied by local hyper‐methylation and hyper‐hydroxymethylation. Hydroxymethylation prefers to distribute in the CpG islands and CpG shores, as displayed a trend of gradual decline from health to CIN2, while a trend of increase from CIN3 to CC. The differentially methylated and hydroxymethylated region‐associated genes both enriched in Hippo and other cancer‐related signaling pathways that drive cervical carcinogenesis. Furthermore, we identified eight novel differentially methylated/hydroxymethylated‐associated genes (DES, MAL, MTIF2, PIP5K1A, RPS6KA6, ANGEL2, MPP, and PAPSS2) significantly correlated with the overall survival of CC. In addition, no any correlation was observed between methylation or hydroxymethylation levels and somatic copy number variations in CINs and CCs. Conclusion Our current study systematically delineates the map of methylome and hydroxymethylome from CINs to CC, and some differentially methylated/hydroxymethylated‐associated genes can be used as the potential epigenetic biomarkers in CC prognosis.
Swedish Primary Care Physicians’ Intentions to Use Telemedicine: A Survey Using a New Questionnaire – Physician Attitudes and Intentions to Use Telemedicine (PAIT)

Background Research on intentions to use telemedicine in primary care is sparse. This survey study explored primary care physicians’ intentions to use telemedicine by using a newly developed questionnaire: Physician Attitudes and Intentions to use Telemedicine. Methods An anonymous web-survey with questions focusing on theory-based predictors of behavioral intentions such as Attitudes, Subjective norms and Perceived behavioral control was designed, validated, and sent to all primary care physicians at 160 primary health care centers in southern Sweden from May to August 2019. The questionnaire had 29 subject items (including 49 multiple-choice sub-items). Main outcome measures were intentions to use three domains of telemedicine and correlation between theory-based predictors and behavioral intentions for using telemedicine. Results The survey was validated by an expert group, amended, and then tested and retested. A majority of the 198 physicians who returned the web-surveys reported that they did not use e-mails (68%), nor video consultations (78%), chat (81%), or text messages (86%) in their everyday patient work. Yet, most physicians described a positive intention to use telemedicine in patient care for all three studied domains with Attitudes and Perceived behavioral control being significant predictors (p<0.01) for Intentions to use digital contacts (R2 = 0.54), chronic disease monitoring with digital tools (R2 = 0.47) and artificial intelligence (R2 = 0.54). A structural validation of a preliminary instrument – Physician Attitudes and Intention to use Telemedicine (PAIT) – containing 28 sub-items was done by exploratory factor analysis with acceptable explanatory, reliability and sampling adequacy measures. Five factors emerged with Eigenvalues between 1.6 and 11.1 explaining 72% of the variance. Total Cronbach’s alpha was 0.91 and Kaiser-Meyer-Olkirk 0.79. Conclusion Before the covid-19 pandemic, Swedish primary care physicians reported a low use yet high behavioral intention to use telemedicine in a study where we developed the preliminary instrument Physician Attitudes and Intention to use Telemedicine. Perceived behavioral control had the largest predictive value of behavioral intention to use telemedicine. Thus, interventions aiming to increase the use of digital tools in primary care should possibly focus on empowering physicians’ self-efficacy towards using them.
Emfit Bed Sensor Activity Shows Strong Agreement with Wrist Actigraphy for the Assessment of Sleep in the Home Setting

Purpose Wrist-worn actigraphy via research-grade devices, a well-established approach to the assessment of rest-activity, is limited by poor compliance, battery life, and lack of direct evidence for time spent physically in the bed. A non-invasive bed sensor (Emfit) may provide advantages over actigraphy for long-term sleep assessment in the home. This study compared sleep-wake measurements between this sensor and a validated actigraph. Patients and Methods Thirty healthy subjects (6 to 54 years) underwent simultaneous monitoring with both devices for 14 days and filled out a daily sleep diary. Parameters included bed entry time, sleep start, sleep end, bed exit time, rest interval duration, and wake after sleep onset (WASO). The agreement between the two devices was measured using Bland–Altman plots and inter-class correlation coefficients (ICC). In addition, sensitivity, specificity, and accuracy were obtained from epoch-by-epoch comparisons of Emfit and actigraphy. Results Fifteen percent of the subjects reported that wearing the actigraph was a burden. None reported that using the bed sensor was a burden. The minimal detectable change between Emfit and actigraphy was 11 minutes for bed entry time, 14 minutes for sleep start, 14 minutes for sleep end, 10 minutes for bed exit time, 20 minutes for rest interval duration, and 110 minutes for WASO. Inter-class correlation coefficients revealed an excellent agreement for all sleep parameters (ICC=0.99, 95% CI 98–99) except for WASO (ICC=0.46, 95% CI 0.33–0.56). Sensitivity, specificity, and accuracy were 0.62, 0.93, and 0.88, respectively. Kappa correlation analysis revealed a moderate correlation between the two devices (κ=0.55, p<0.0001). Conclusion Emfit is an acceptable alternative to actigraphy for the estimation of bed entry time, sleep start, sleep end, bed exit time, and rest interval duration. However, WASO estimates are poorly correlated between the two devices. Emfit may offer methodological advantages in situations where actigraphy is challenging to implement.
The effect of silymarin on liver enzymes and antioxidant status in trauma patients in the intensive care unit: a randomized double blinded placebo-controlled clinical trial

Aim of the study This study was conducted to investigate the positive effect of silymarin on liver enzymes and antioxidant status in trauma patients with elevated liver enzymes due to trauma-induced liver injury, admitted to the intensive care unit. Material and methods This one-year, randomized, double-blinded, placebo-controlled clinical trial was conducted on 90 trauma patients. The participants were assigned to either receiving Livergol tablets containing 140 mg of silymarin or 140 mg of placebo three times daily for 14 days. Liver enzymes, including aspartate transaminase (AST), alanine transaminase (ALT) and alkaline phosphatase (ALP), were measured at baseline and days 3, 7, 9 and 14 after intervention. Also, antioxidant markers were measured at baseline and day 14 after treatment. Results Receiving silymarin supplement significantly lowered the liver enzymes, compared to placebo (p < 0.05). The mean serum level of malondialdehyde (MDA) was significantly decreased and the mean serum levels of total antioxidant capacity (TAC) and thiol groups were significantly increased in the silymarin group from baseline to day 14. In the placebo group, mean serum levels of MDA and thiol groups were significantly increased, while serum level of TAC was not significantly changed at day 14, compared to baseline. Also, the mean serum level of MDA was significantly lower, while the serum levels of thiol groups and TAC were significantly higher in the silymarin group. Conclusions Silymarin supplementation significantly improved some antioxidant markers (TAC and thiol) and decreased liver enzymes in patients with trauma-induced liver injury.
Assessment of the Frequency of Depressive Symptoms in Epileptic Children (Single Center Study)

Background Epilepsy, the most common neurological disorder in children, may present with many psychiatric comorbidities, the most common of which is depression. Aim of the Work We evaluated the frequency of depressive symptoms in epileptic children, with regard to the possible association between depression and their demographic data or seizure-related variables. Patients and Methods This cohort study was conducted on 80 children (6–13 years old) diagnosed as idiopathic epilepsy and were regularly recruiting the pediatric neurology clinic at Minya University Children Hospital. The Structured Birleson Depression Scale Questionnaire was used for assessment of presence of depressive symptoms, and Quality Of Life in Epilepsy (QOLIE-31) score was used to assess quality of life in those patients. Results Depressive symptoms were found in 37.5% of enrolled patients. There were statistically significant differences between the patients with depressive symptoms and the other group regarding age (p=0.001), residence (p=0.006) and past history of mood disorders (p=0.03). Sleep disturbance was the highest predictor of depression in cases with depressive symptoms, detected in 90% of cases, followed by appetite disturbance in 86.6% of cases, while delusions and hallucinations were the lowest, detected in only 10% of cases. Both duration of epilepsy and frequency of seizures were significantly higher in cases with depressive symptoms than the other group (p=0.001) for both. QOLIE score was significantly lower in cases with depressive symptoms than the other group (p= 0.01 for all). Conclusion Depressive symptoms are common in epileptic children, and it is often challenging and underestimated. It should be screened during the management of such children. Early diagnosis and more comprehensive package of care for depression in epileptic children will enable them to have a better quality of life.
Serum and ascitic D-dimer in cirrhotic patients with spontaneous bacterial peritonitis

Aim of the study The study aimed to investigate serum and ascitic fluid D-dimer level in patients with liver cirrhosis with and without ascites and to evaluate the impact of spontaneous bacterial peritonitis (SBP) on circulating serum and ascitic fluid D-dimer levels. Material and methods This study was conducted on 60 subjects who were further subdivided into group I comprising 15 patients with liver cirrhosis and no ascites, group II comprising 15 cirrhotic patients with ascites, group III comprising 15 cirrhotic patients with ascites and SBP, and group IV comprising 15 healthy controls. All patients were subjected to full history taking, physical examination, laboratory investigations, and measurement of serum D-dimer in all groups and ascitic fluid D-dimer in groups II and III. The diagnostic performance of serum D-dimer was tested to detect SBP. Results Serum D-dimer differed significantly between groups III and IV, whilst no significant differences were detected between the other groups and group IV. Moreover, group III showed a significantly higher level of serum D-dimer. Ascitic fluid D-dimer mean levels showed no statistically significant differences. A statistically significant positive correlation was found between serum D-dimer level and ascitic fluid D-dimer in group III, r = 0.682. Using a sensitivity and specificity level of 80%, a cut-off value (COV) of > 323.2 ng/ml could differentiate between patients with SBP and patients with ascites only. Conclusions Serum D-dimer significantly correlated with ascitic fluid D-dimer in patients with SBP, whereas no significant correlation was found in patients with cirrhotic ascites without bacterial infection. D-dimer showed good diagnostic performance for SBP among patients with liver cirrhosis.
Optimization and Pharmacokinetic Evaluation of Synergistic Fenbendazole and Rapamycin Co-Encapsulated in Methoxy Poly(Ethylene Glycol)-b-Poly(Caprolactone) Polymeric Micelles

Purpose We aimed to develop a nanocarrier formulation incorporating fenbendazole (FEN) and rapamycin (RAPA) with strong efficacy against A549 cancer cells. As FEN and RAPA are poorly soluble in water, it is difficult to apply them clinically in vivo. Therefore, we attempted to resolve this problem by encapsulating these drugs in polymeric micelles. Methods We evaluated drug synergy using the combination index (CI) values of various molar ratios of FEN and RAPA. We formed and tested micelles composed of different polymers. Moreover, we conducted cytotoxicity, stability, release, pharmacokinetic, and biodistribution studies to investigate the antitumor effects of FEN/RAPA-loaded mPEG-b-PCL micelles. Results We selected mPEG-b-PCL-containing FEN and RAPA at a molar ratio of 1:2 because these particles were consistent in size and had high encapsulation efficiency (EE, %) and drug loading (DL, %) capacity. The in vitro cytotoxicity was assessed for various FEN, RAPA, and combined FEN/RAPA formulations. After long-term exposures, both the solutions and the micelles had similar efficacy against A549 cancer cells. The in vivo pharmacokinetic study revealed that FEN/RAPA-loaded mPEG-b-PCL micelles had a relatively higher area under the plasma concentration–time curve from 0 to 2 h (AUC0–2 h) and 0 to 8 h (AUC0–8 h) and plasma concentration at time zero (Co) than that of the FEN/RAPA solution. The in vivo biodistribution assay revealed that the IV injection of FEN/RAPA-loaded mPEG-b-PCL micelles resulted in lower pulmonary FEN concentration than the IV injection of the FEN/RAPA solution. Conclusion When FEN and RAPA had a 1:2 molar ratio, they showed synergism. Additionally, using data from in vitro cytotoxicity, synergism between a 1:2 molar ratio of FEN and RAPA was observed in the micelle formulation. The FEN/RAPA-loaded mPEG-b-PCL micelle had enhanced bioavailability than the FEN/RAPA solution.
Pemafibrate improves hepatic inflammation, function and fibrosis in patients with non-alcoholic fatty liver disease: a one-year observational study

Aim of the study To optimize the long-term outcomes of patients with non-alcoholic fatty liver disease (NAFLD), long-term therapy is important to prevent cirrhosis and hepatocellular carcinoma. Pemafibrate, a novel selective peroxisome proliferator-activated receptor-α modulator, is a promising therapeutic agent for patients with NAFLD. However, only short-term clinical studies are currently available. The aim of this study is to evaluate the long-term outcomes of patients with NAFLD treated with pemafibrate. Material and methods This is a retrospective observational study. Patients with NAFLD treated with pemafibrate 0.1 mg twice daily for one year were retrospectively reviewed. Results Twenty-two patients without diabetes mellitus were included and analyzed. Regarding hepatic inflammation markers, alanine aminotransferase (ALT) significantly decreased during the first three months and was maintained. Low-density lipoprotein and triglycerides significantly decreased at three months and were maintained. Regarding markers of hepatic function, the albumin-bilirubin score decreased significantly during one year of therapy due to significantly elevated serum albumin and decreased total bilirubin levels. Regarding markers of fibrosis, Mac-2 binding protein glucosylation isomer (M2BPGi) significantly decreased, and platelet count increased significantly. Next, we performed correlation analysis between changes in M2BPGi and other parameters. Changes in aspartate aminotransferase, ALT and triglycerides positively correlated with the change in M2BPGi. Conclusions One-year pemafibrate therapy improves markers of hepatic inflammation, function and fibrosis in non-diabetic patients with NAFLD. Improvement of hepatic fibrosis markers significantly correlates with improvement of hepatic inflammation markers and triglyceride levels.