Miracle-dz/UniFAR-FTUs huggingface dataset:
Migration and Growth in a Schumpeterian Growth Model with Creative Destruction

: This paper incorporates endogenous migration into a second-generation Schumpeterian growth model to study how migration, innovation and growth interact one another. I (cid:133)nd that migration always enhances the rates of innovation and growth of the receiving economy, but also that the other way round is not true when the gap in technical knowledge between country is (cid:133)xed over time. However, when the technology gap is allowed to adjusts endogenously, I (cid:133)nd that implementing pro-innovation policies in the receiving economy shrinks immigration (cid:135)ows and reduces the across-country technology.
Short Report: Empyema Caused by Aeromonas Species in Taiwan

Strains of Aeromonas species are prevalent bacteria in coastal areas of southern Taiwan. Aeromonad is known as a cause of epidemic diarrheal disease, and the most common clinical manifestation is acute gastroenteritis. Extra-intestinal infections by Aeromonas species, such as pleural cavity, are rare. Herein, we described the six patients who developed Aeromonas spp. -related empyema, and was successfully treated with antimicrobial agent and drainage. Aeromonas species, a curved Gram-negative rod, causes human infection through exposure to contaminated sea water or ingestion of contaminated seafood. 1 Acute gastroenteritis is the most common clinical manifestation of Aeromonas infection, however the extra-intestinal involvement, including bacteremia, necrotizing fasciitis, arthritis, endocarditis, cholangitis, meningitis, pneumonia, skin and soft tissue infection, has rarely been reported. 1 – 7 Herein, we perform this study to find the cases of unusual presentation of Aeromonas infections — empyema and further investigate its associated clinical manifestations and microbiology characteristics. This study was conducted at Chi Mei Medical Center, Liouying branch, a 900-bed tertiary care center in southern Taiwan. From the computerized database of the bacteriology laboratory from July 2004 to December 2011, patients whose cultures yielded Aeromonas species were identified. The clinical charts of all patients with empyema caused by Aeromonas species included in this study were retrospectively reviewed. age, gender,
In vivo Gene Silencing of CD81 by lentiviral expression of siRNAs suppresses Cocaine-induced Behaviour

The tetraspanin CD81 is induced in the mesolimbic dopaminergic pathway after cocaine administration. To further investigate its role, a regulatable lentivirus (Lenti-CD81), bearing the CD81 gene under the control of a tetracycline inducible promoter, and lentiviruses expressing shRNA targeted against CD81 (Lenti-CD81-shRNAs) have been prepared. Infection of HEK293T cells in vitro with Lenti-CD81-shRNAs resulted in 96.5% gene silencing (from qRT-PCR and immunocytochemistry). In vivo delivery of Lenti-CD81-shRNA into the nucleus accumbens (NAcc) or the ventral tegmental area (VTA) resulted in 91.3% and 94% silencing of endogenous CD81 respectively. Stereotaxic injection of Lenti-CD81 into these regions, resulting in CD81 overexpression, induced a 4 to 5-fold increase in locomotor activity after chronic cocaine administration, which returned to basal levels when Lenti-CD81-shRNA had been co-injected or when CD81-expression was blocked by doxycycline. Furthermore silencing endogenous CD81 in vivo resulted in a significant decrease in locomotor activity over controls, again suppressing cocaine-induced behaviour. the real-time PCR iCycler (BioRad, Switzerland). For PCR, 5 (cid:80) l cDNA preparation, 0.5 (cid:80) M of forward and reverse primers and 10 (cid:80) l of IQ SYBR Green Supermix (Biorad, Switzerland) in a total volume of 20 (cid:80) l were applied. The following PCR program was performed: 3 min at 95 °C (initial denaturation); 20 °C/sec temperature transition rate up to 95 °C for 45 sec, 45 sec 62 °C, repeated for 40 times (amplification). The PCR reaction was evaluated by melting curve analysis following the manufacturer’s instructions and checking the PCR products on 2 % agarose gel. Values for CD81 overexpression were calculated against the signal for GAPDH (or (cid:69) -actin), selected as endogenous, constitutively expressed control mRNAs for normalization. No difference was observed whether GAPDH or (cid:69) -actin was used for all normalizations. The levels for NAcc or VTA samples from cocaine-injected rats were normalized to the levels for the samples from saline-treated animals within the same experiment. PCR amplifications were done at least in triplicate from 3-pooled samples isolated from separate pools of animals or cells and the PCR cycle number at which each assay target reached the threshold detection line was determined (“threshold cycles”, Ct value), using the second derivative of the reaction. The C t of each gene was normalized against that of GAPDH (or (cid:69) -actin). To determine the linearity and detection limit of the assay, cDNA samples were amplified for successive 10-fold dilutions in a series of real-time PCRs, using duplicate assay on each dilution, so that the correlation coefficient could be calculated from the standard curve of Ct values. Comparisons were made between cocaine and saline groups and significance was calculated using two-tailed Student’s t test and the level of statistical significance was set at
OP-MOLB150107 1996..2000

LBD (LATERAL ORGAN BOUNDARIES DOMAIN) genes are essential to the developmental programs of many fundamental plant organs and function in some of the basic metabolic pathways of plants. However, our historical perspective on the roles of LBD genes during plant evolution has, heretofore, been fragmentary. Here, we show that the LBD gene family underwent an initial radiation that established five gene lineages in the ancestral genome of most charophyte algae and land plants. By inference, the LBD gene family originated after the emergence of the green plants (Viridiplantae), but prior to the diversification of most extant streptophytes. After this initial radiation, we find limited instances of gene family diversification in land plants until successive rounds of expansion in the ancestors of seed plants and flowering plants. The most dynamic phases of LBD gene evolution, therefore, trace to the aquatic ancestors of embryophytes followed by relatively recent lineage-specific expansions on land.
08 Froneman (2223) (JB)

Mysids are a ubiquitous component of the zooplankton assemblages in a variety of aquatic environments (Mauchline, 1980; Price, 1982; Webb et al. 1987; Grange, 1992; Jerling and Wooldridge, 1995). Although generally representing a small component of the total zooplankton abundance, they may, at times, comprise a significant proportion (up to 20%) of the total zooplankton biomass. Mysids are generally considered omnivorous (Siegfried and Kopache, 1980; Grossnickle, 1982; Jerling and Wooldridge, 1995) although herbivory (Webb et al., 1987) or carnivory (Fulton, 1982) has been reported for some species. There are also data in the literature to suggest that the composition of the mysids’ diet changes with developmental stage, with herbivory dominating among juveniles and carnivory among adults (Siegfried and Kopache, 1980). The Kariega estuary (33°41 S; 26°42 E) is situated on the eastern seaboard of South Africa. As a result of low annual freshwater influx, the estuary is regarded as a homogeneous oligotrophic marine system (Whitfield, 1992; Grange and Allanson, 1995). The limited freshwater influx into the estuary is the result of several factors, including sporadic rainfall, small catchment area (±680 km2) and the presence of several impoundments
The AC 2000: The Astrographic Catalogue on the System Defined by the Hipparcos Catalogue

The AC 2000 is a positional catalog of 4,621,836 stars covering the entire sky. The average epoch of position is 1907. The data are from the images measured and published as part of the Astrographic Catalogue (AC). The positions are on the system defined by the Hipparcos Catalogue, having originally been reduced plate-by-plate using the Astrographic Catalog Reference Stars. In addition to the astrometric data, magnitudes (on the Tycho B system) and cross-referencing information are included. These positions are valuable for the computation of proper motions, and were combined with the positions from the recently released Tycho Catalogue to improve proper motions of almost 1 million stars. The resulting catalog is known as the ACT Reference Catalog (the name ACT is from AC 2000 and Tycho). Both the AC 2000 and ACT are now available on CD-ROM and can be obtained by contacting the first author above. A World Wide Web site describing various aspects of the reductions is also maintained by the Astrometry Department, US Naval Observatory.
DICER1-AS1 Promotes the Malignant Behaviors of Colorectal Cancer Cells by Regulating miR-296-5p/STAT3 Axis

Background: Long non-coding RNA (lncRNA) exerts a regulatory role in the occurrence and progression of tumors. This study aimed at probing into the function and mechanism of lncRNA DICER1 antisense RNA 1 (DICER1-AS1) in colorectal cancer (CRC). Methods: The expressions of DICER1-AS1, miR-296-5p and STAT3 mRNA were tested by quantitative real-time polymerase chain reaction (qRT-PCR). Cell counting kit-8 (CCK-8) assay was employed to detect cell proliferation, and Transwell was used to detect cell migration and invasion. In addition, the expressions of apoptosis-related proteins Bax and Bcl2 were detected by Western blot. Interactions between DICER1-AS1 and miR-296-5p, and miR-296-5p and STAT3 were predicted and determined by bioinformatics analysis, luciferase reporter assay and RNA binding protein immunoprecipitation (RIP) assay. Results: The expressions of DICER1-AS1 and STAT3 mRNA were significantly up-regulated while miR-296-5p expression was remarkably down-regulated in CRC tissues and cell lines. Over-expression of DICER1-AS1 or transfection of miR-296-5p inhibitors could promote the proliferation, migration and invasion and inhibit apoptosis of CRC cells, whereas knockdown of DICER1-AS1 or transfection of miR-296-5p mimics had the opposite effects. Additionally, DICER1-AS1 could down-regulate miR-296-5p expression via spong-ing it. DICER1-AS1 also enhanced the expression of STAT3, which was identified as a target gene of miR-296-5p. Conclusion: DICER1-AS1 acts as an oncogenic lncRNA in CRC via modulating miR-296-5p/STAT3 axis. Our results provide a new direction for the diagnosis and treatment of CRC.
The atmospheric impacts of monoterpene ozonolysis on global stabilised Criegee intermediate budgets and SO2 oxidation:

The gas-phase reaction of alkenes with ozone is known to produce stabilised Criegee intermediates (SCIs). These biradical/zwitterionic species have the potential to act as atmospheric oxidants for trace pollutants such as SO 2 , enhancing the formation of sulfate aerosol with impacts on air quality and health, radiative transfer and climate. How-ever, the importance of this chemistry is uncertain as a consequence of limited understanding of the abundance and atmospheric fate of SCIs. In this work we apply experimental, theoretical and numerical modelling methods to
DENTAL PROFESSIONALS PERSPECTIVES ABOUT THE CONSUMER PROTECTION ACT AND ETHICAL PRACTICES IN PATNA, BIHAR

The dental profession is a vocation in which knowledge and skill is used for the service of others. Throughout the world, patients have become more aware of their rights & legal literacy to which India is no exception. The Consumer Protection Act(COPRA) has been formulated for the promotion and protection of the rights of consumers. On the other hand, for the dentists; The dentists (Code of Ethics) regulations were laid down by the Dental Council of India in 1976; later revised in the year 2014. Aim: To assess the awareness of the Consumer Protection Act and ethical practices amongst dental professionals of Patna, Bihar. Methodology: A descriptive cross-sectional study was conducted among 200 dental professionals of Patna, Bihar. Simple random sampling was done. A close-ended questionnaire containing 30 items was used for data collection. Data were collected, compiled & tabulated using Microsoft excel & analyzed by Chi-square test with p < 0.05 as significant. Results: The dental professionals with postgraduate degree and undergraduate degree were 51.50% and 48.50% respectively. A total of 53% of the study participants were aware about COPRA and 86.5% subjects thought that knowledge of ethics is important for them in their work. Qualification and practice experience were significantly associated with awareness towards COPRA(p=0.0001). Conclusion: The study revealed that the participants with higher qualification and those who are practitioners had better knowledge and awareness towards COPRA and code of ethics.
The Relation between Trace Element Composition of Cu-(Fe) Sulﬁdes and Hydrothermal Alteration in a Porphyry Copper Deposit: Insights from the Chuquicamata Underground Mine, Chile Metal Tracing Along

: Porphyry Cu-Mo deposits are among the world’s largest source of Cu, Mo, and Re, and are also an important source of other trace elements, such as Au and Ag. Despite the fact that chalcopyrite, bornite, and pyrite are the most common sulﬁdes in this deposit type, their trace element content remains poorly constrained. In particular, little is known about minor and trace elements partitioning into Cu-(Fe) sulﬁdes as a function of temperature and pH of the hydrothermal ﬂuid. In this study, we report a comprehensive geochemical database of chalcopyrite, bornite, and pyrite in the super-giant Chuquicamata porphyry Cu-Mo deposit in northern Chile. The aim of our study, focused on the new Chuquicamata Underground mine, was to evaluate the trace element composition of each sulﬁde from the different hydrothermal alteration assemblages in the deposit. Our approach combines the electron microprobe analysis (EMPA) and laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) of sulﬁde minerals obtained from six representative drill cores that crosscut the chloritic (propylitic), background potassic, intense potassic, and quartz-sericite (phyllic) alteration zones. Microanalytical results show that chalcopyrite, bornite, and pyrite contain several trace elements, and the concentration varies signiﬁcantly between hydrothermal alteration assemblages. Chalcopyrite, for example, is a host of Se ( ≤ 22,000 ppm), Pb ( ≤ 83.00 ppm), Sn ( pyrite (e.g., Ag/Co and Co/Cu) bear the potential for vectoring towards porphyry mineralization and higher Cu resources.
A NOVEL TECHNIQUE FOR MEASURING LOCAL BUBBLE SIZE DISTRIBUTION

: A novel experimental technique for measuring the local gas hold-up and the statistical distribution of local bubble size, is proposed. The technique is based on laser sheet illumination of the gas-liquid dispersion and synchronized camera, i.e. on equipment typically available in PIV set-ups. The liquid phase is made fluorescent by a suitable dye, and a band-pass optical filter is placed in front of the camera optics, in order to allow only fluoresced light to reach the camera CCD. In this way bubbles intercepted by the laser sheet are clearly identified thanks to the neat shade resulting in the images. This allows excluding from subsequent analysis all bubbles visible in the images but not actually intercepted by the laser sheet, so resulting in better spatial resolution and data reliability. Preliminary data obtained in a stirred gas-liquid dispersion confirm the technique viability and reliability.
Overestimation of Human Immunodeﬁciency Virus Type 1 Load Caused by the Presence of Cells in Plasma from Plasma Preparation Tubes (cid:1)

The human immunodeﬁciency virus type 1 (HIV-1) load is an important marker of disease progression and treatment efﬁcacy in patients with HIV-1 infection. In recent years, an increase in the number of samples with detectable HIV-1 RNA has been reported among patients with previously suppressed viral loads, affecting clinical patient care and leading to repeat measurements of viral load and drug resistance. This rise seems to have coincided with the increased use of plasma preparation tubes (PPTs) for sample collection, and we have aimed to explain why PPTs might yield elevated HIV-1 RNA levels. The impacts of different sample-processing procedures on HIV-1 RNA levels were compared retrospectively. Prospectively, the presence of different cells and cell-associated HIV-1 nucleic acids in paired plasma samples from PPTs centrifuged before (PPT1) and after (PPT2) transportation to the laboratory was compared. A retrospective analysis of 4,049 patient samples with <1,000 HIV-1 RNA copies/ml showed elevated HIV-1 RNA levels in plasma from PPT1 compared with the levels from PPT2 and standard EDTA-containing tubes. Prospective data revealed cell-associated HIV-1 nucleic acids and abundant blood cells in plasma from PPT1 but not from the corresponding PPT2. The levels of HIV-1 RNA correlated with the lymphocyte counts in plasma in PPT1. Cells could be removed by the recentrifugation of PPT1 before analysis. In conclusion, the transportation of PPTs after centrifugation may render cells in the plasma fraction containing cell-associated HIV-1 nucleic acids that contribute signiﬁcantly to the HIV-1 RNA copy numbers in patients with low viral loads.
How Treat How I treat ﬁ rst relapse of myeloma

The standard treatment of relapsed multiple myeloma has been either lenalidomide-dexamethasone (RD) or bortezomib-dexamethasone (VD) but it is changing rapidly for 2 reasons. First, lena-lidomideandbortezomibarecurrentlyused in frontline treatment and many patients become resistant to these agents early in the course of their disease. Second, 6 second-linenewagentshavebeenrecently developed and offer new possibilities (pomalidomide, carfilzomib and ixazomib, panobinostat, elotuzumab, and daratumu-mab). Recent randomized studies have shown that triple combinations adding 1 of these new agents (except pomalidomide) to the RD or VD regimens were superior to the double combinations in terms of response rate and progression-free survival (PFS). Their place in the treatmentoffirstrelapseisdiscussedhere. Among these agents, daratumumab is clearly a breakthrough and daratumumab-based combinations might become the preferred option in the near future. However, all of these drugs are expensive and are not available or affordable in all countries. We propose a decision algorithm for first relapse in fit patients with the objective of achieving the best PFS. The choice of salvage regimen is based on lenalidomide/bortezomib resistance, dara-tumumabavailability,andcost.Autologous transplantation should be considered in youngerpatientsifnotusedupfront. ( Blood . 2017;130(8):963-973)
Distant healing intention therapies demonstrate effectiveness in humans with diagnosed health complications

Overview: “Distant Healing Intention Therapies” (DHIT) – including distance healing, therapeutic touch, Reiki, Qi-therapy, and intercessory prayer – are commonly utilized complementary and alternative medicine practices. While trials have demonstrated that DHIT alter patient reported health outcomes and physiological metrics, studies utilizing DHIT are often criticized for poor methodology leading to uncertainty and a deficiency in the confidence of the reported statistically significant effects. Previous systematic reviews and meta-analyses of DHIT have generated mixed results supporting the effectiveness of DHIT. None of these studies solely focused on populations with diagnosed health complications. As a result, a review was conducted of randomized controlled trials studying humans with illnesses or injuries receiving DHIT to survey the quantity and quality of the literature and analyze the effectiveness of these therapies to promote healing. Methods : Fifty-seven randomized controlled trials were extracted from PubMed/MEDLINE, Swetswise, ASSIA, Psych-NET, Web of Science, Cochrane Library, British Nursing Index, Cinahl Full Text, and Informaworld. A quality assessment of internal validity was conducted using the Scottish Intercollegiate Guidelines Network (SIGN 50). Results: Ten (18%) studies were classified as high quality, 22 (39%) as adequate quality, and 25 (44%) as poor quality. Of the 57 studies, 28 (49%) demonstrated at least one significant outcome favoring DHIT compared to an active control or placebo. Four high quality (14%), 11 adequate quality (39%), and 13 poor (46%) quality studies demonstrated significant results. Conclusions: The methodological quality and outcomes of DHIT studies are extremely heterogeneous. Nearly half of the appraised studies revealed statistically significant results. Hence, this review concludes that while DHIT can effectively treat patients with diagnosed health complications, it cannot be determined if changes in the measured outcomes are directly due to the interventions or to placebo responses, such as the meaning and context created by undergoing a therapy. Ultimately, no recommendation for or against the use of these therapies can be made until future research with stronger internal validity is conducted.
The principles of the testing invariance measurement over time 1

Most social phenomena that are the subject of contemporary large national and international surveys are intended to be studied over the long term – the aim is to observe their development over time. A critical part of the observation of any social phenomenon over time is ensuring that the measurement of it remains invariant. However, this condition is not altogether easy to achieve in practice. Invariant measurement requires at the very least the following:
The Effect Of Merger And Acquisition On Financial Performance Of Companies In Iraq

Mergers and acquisitions(M & A) made by the company to obtaining an advantage. Situation will occur when merger and acquisition activity is gaining synergies, as a result of company synergies expected to improve the financial performance of the company. This research aims to analyze the differences in companyfinancial performance before and after mergers and acquisitions on company merger and acquisition activity. Company performance is measured by using financial ratio: Return on Assets (ROA), on Rreturn on Equity (ROE), Earnings per Share (EPS), Net Profit Margin (NPM). Quantitative methods is used in this research, take the data from all public companies doing mergers and acquisitions in IraqStockExchange through the period from 2008 to 2013, the practice of the research made by using the purposive sampling method, with data obtained by 10companyas sample of mergers and acquisitions at the same period of research. The results of this research revealed, through the use of the four financial indicators ROA, ROE, EPS, NPM, a number of conclusions, the most prominent of which was showed significant results in several years of observation, comparison before and after mergers and acquisitions. Only the (NPM) that did not show a difference in the whole year of observation before and after mergers and acquisitions. However, the descriptive statistics changes towards the positive on the entire financial ratios after mergers and acquisitions that show the synergy obtained by companies that do mergers and acquisitions.