Miracle-dz/UniFAR-FTUs huggingface dataset:
Linking Career Anxiety with Suicide Tendencies among University Undergraduates

Suicide is increasingly becoming a worldwide public health issue. The issue of suicide in universities is one of the most pressing concerns in Nigeria and the world. Yet, it has not been clear the factors that account for increased suicide among university students. This study investigated the link between career anxiety and suicidal tendencies among university undergraduates. The study was cross-sectional correlational and used a sample of 3,501 undergraduates in Nigeria. Career anxiety was measured using the two-factor career anxiety scale (CAS -2). At the same time, suicide tendencies were weighed using the Multi-attitude Suicide Tendency Scale (MAST), and Suicidal Ideation Attributes Scales (SIDAS). Data collected were analyzed using percentages to interpret demographic data. Mean and standard deviation was presented for descriptive purposes. Linear regression was used to explore the links between career anxiety and suicidal tendencies at p < 0.05 level of significance. Results indicated that a high level of career anxiety was significantly correlated with increased suicidal tendencies, such as repulsion for life, attraction to death, and suicidal ideation. A low level of career anxiety was associated with decreased suicidal tendencies, characterized by an increased attitude toward attraction to life and repulsion to death. It was concluded that students with problematic career anxiety are likely to report a negative attitude toward life, which leads to increased suicidal ideation. Accordingly, career anxiety may cause one to seriously consider or contemplate suicide.
On Korn’s constant for thin cylindrical domains

We consider an ε-parametrized collection of cylinders of cross section εω, where ω ⊂ ℝ 2 , and of fixed length ℓ. By Korn’s inequality, there exists a positive constant Kε such that ∫ Ω ε | sym ∇ u | 2 d 3 x ≥ K ε ∫ Ω ε | ∇ u | 2 d 3 x provided that u ∈ H 1 ( Ω ; ℝ 3 ) satisfies a condition that rules out infinitesimal rotations. We show that Kε∕ε2 converges to a strictly positive limit, and we characterize this limit in terms of certain parameters that depend on the geometry of ω and on ℓ.
The Cytokine Profile in Different Stages of Schistosomiasis Japonica

To explore and profile the level of cytokines in the sera of patients infected with Schistosoma japonicum to explore the helper T-cell response of patients either at the chronic or advanced stage of the disease. We randomly selected 58 subjects from several areas endemic for schistosomiasis japonica in China and collected serum samples to be tested for 18 different cytokines secreted by (1) Th1/Th2 cells (GM-CSF, IFN-γ, IL-1β, IL-2, IL-4, IL-5, IL-6, IL-12p70, IL-10, IL-13, IL-18 and TNF-α) and (2) Th9/Th17/Th22/Treg cells (IL-9, IL-17A, IL-21, IL-22, IL-23 and IL-27). The Th1/Th2 cytokines in chronic patients were not significantly different from those in healthy people, while patients with advanced schistosomiasis had higher levels of IL-2, IL-23 and IL-27 and lower levels of IL-18 and IFN-γ. With respect to the Th9/Th17/Th22/Treg cell cytokines, there were higher levels of IL-23. Thus, a limited variation of the cytokine response between the three patient groups was evident, but only in those with advanced infection, while there was no difference between chronic schistosomiasis infection and healthy subjects in this respect. The cytokine expression should be followed in patients with advanced schistosomiasis who show a cytokine pattern of a weakened Th1 cell response and an increased Th17 response.
The Effect of Instagram Content Quality on Fomsumerism Behavior with Emotional Response as a Mediating Variable

Social media growth has changed consumer behaviour from offline consumption to online consumption. Social media provide opportunities for information sharing, and can routinely find out what others are doing and talking about. Instagram is a social media platform with visual elements and features that can provide a more comfortable space for social interaction and a stronger sense of community or connection between fellow users. The rapid growth of social media plays a vital role in creating feelings of fear of being left behind or fear of missing out (FoMO). FoMO behaviour can impact consumption and give rise to a new concept, "Fomsumerism". This study aimed to determine the effect of Instagram content quality on fomsumerism behaviour mediated by emotional response variables. This type of quantitative research uses non-probability sampling methods and purposive sampling techniques on 150 respondents. An online survey collected data and analyzed using SEM-PLS through the SmartPLS application version 3.9. 9. The study results show that the quality of Instagram content positively and significantly affects fomsumerism behaviour. Emotional response as a mediating variable plays a partial mediation role so that the Instagram content quality variable can affect the fomsumerism variable directly or indirectly.
Synergistic effects of transcutaneous vagus nerve stimulation and inhibitory control training on electrophysiological performance in healthy adults

Transcutaneous vagal nerve stimulation (tVNS) is a non-invasive nerve stimulation technique that exerts a positive “exogenous” online neuromodulatory effect on inhibitory control (IC). Additionally, IC training (ICT) is an effective approach for enhancing IC via the “endogenous” activation of brain regions implicated in this process. The aim of the present study was to examine the synergistic effects of tVNS and ICT on IC enhancement. For this, we measured the changes in neural activity in frontal, fronto-central, and central regions in the time domain of the N2 component and the frequency domain of alpha power during the stop signal task. A total of 58 participants were randomly divided into four groups that received five sessions of either ICT or sham ICT with either online tVNS or sham tVNS. No differences in N2 amplitude were detected after any of the interventions. However, N2 latency shortened after tVNS + ICT in frontal, fronto-central, and central regions. N2 latency shortened after the intervention of sham tVNS + ICT in frontal region. Moreover, alpha power after tVNS + ICT intervention was larger than those of the other interventions in frontal, fronto-central, and central regions. The obtained electrophysiological data suggested that combining tVNS with ICT has synergistic ameliorative effects on IC, and provide evidence supporting the IC-enhancing potential of tVNS combined with ICT.
Quantifying the Local Economic Growth Impact of Hurricane Strikes: An Analysis from Outer Space for the Caribbean

AbstractStudies of the impact of hurricanes on economic activity typically are restricted to a very aggregate level of analysis because of the lack of spatially disaggregated data. In this paper nightlight satellite imagery is employed as a measure of local economic activity in conjunction with a local proxy for potential hurricane destruction generated from a wind field model to statistically assess the impact of hurricane strikes on local economic growth. The regression results suggest that on average hurricane strikes reduce income growth by around 1.5% at the local level, with no effect beyond the year of the strike. This estimated impact from localized data is more than 2 times that implied by aggregate analyses.
Nonlinear wakes behind a row of elongated roughness elements

This paper is concerned with the high Reynolds number flow over a spanwise-periodic array of roughness elements with interelement spacing of the order of the local boundary-layer thickness. While earlier work by Goldstein et al. (J. Fluid Mech., vol. 644, 2010, pp. 123–163) and Goldstein et al. (J. Fluid Mech., vol. 668, 2011, pp. 236–266) was mainly concerned with smaller roughness heights that produced relatively weak distortions of the downstream flow, the focus here is on extending the analysis to larger roughness heights and streamwise elongated planform shapes that together produce a qualitatively different, nonlinear behaviour of the downstream wakes. The roughness scale flow now has a novel triple-deck structure that is somewhat different from related studies that have previously appeared in the literature. The resulting flow is formally nonlinear in the intermediate wake region, where the streamwise distance is large compared to the roughness dimensions but small compared to the downstream distance from the leading edge, as well as in the far wake region where the streamwise length scale is of the order of the downstream distance from the leading edge. In contrast, the flow perturbations in both of these wake regions were strictly linear in the earlier work by Goldstein et al. (2010, 2011). This is an important difference because the nonlinear wake flow in the present case provides an appropriate basic state for studying the secondary instability and eventual breakdown into turbulence.
Overexpression of CHAF1A is associated with poor prognosis, tumor immunosuppressive microenvironment and treatment resistance

Background: As distinct marker of proliferating cells, chromatin assembly factor-1 (CAF-1) was critical in DNA replication. However, there is paucity information about the clinical significance, functions and co-expressed gene network of CHAF1A, the major subunit in CAF-1, in cancer. Methods: Bioinformatic analysis of CHAF1A and its co-expression gene network were performed using various public databases. Functional validation of CHAF1A was applied in breast cancer. Results: Overexpression of CHAF1A was found in 20 types of cancer tissues. Elevated expression of CHAF1A was positively correlated with breast cancer progression and poor patients’ outcome. The analysis of co-expression gene network demonstrated CHAF1A was associated with not only cell proliferation, DNA repair, apoptosis, but cancer metabolism, immune system, and drug resistance. More importantly, higher expression of CHAF1A was positively correlated with immunosuppressive microenvironment and resistance to endocrine therapy and chemotherapy. Elevated expression of CHAF1A was confirmed in breast cancer tissues. Silencing of CHAF1A can significantly inhibit cell proliferation in MDA-MB-231 cells. Conclusion: The current work suggested that overexpression of CHAF1A can be used as diagnostic and poor prognostic biomarker of breast cancer. Higher expression of CHAF1A induced fast resistance to endocrine therapy and chemotherapy, it may be a promising therapeutic target and a biomarker to predict the sensitivity of immunotherapy in breast cancer.
Awareness of the Ayushman Bharat-Pradhan Mantri Jan Arogya Yojana in the Rural Community: A Cross-Sectional Study in Eastern India

Background Ayushman Bharat-Pradhan Mantri Jan Arogya Yojana (AB-PMJAY) is one of the flagship programs intended to provide financial protection to people availing of secondary and tertiary level health care. It’s been nearly three years since the implementation of AB-PMJAY in Bihar, yet the level of awareness, especially in rural communities, is unknown. So, this study was planned to explore the awareness and utilization of AB-PMJAY in the selected rural area of Bihar. Methodology This community-based cross-sectional study used a multistage sampling strategy to select 802 households within a radius of 5 Km from the rural health training centre, Naubatpur. A pre-tested, semi-structured questionnaire was used to collect the necessary data regarding awareness of AB-PMJAY. The association between category, occupation, education, age group, and ration card with the awareness of AB-PMJAY was assessed using Pearson’s chi-square test. Results The awareness of the AB-PMJAY was 68.6% (95% CI: 65.30%-71.7%), while out of 459 eligible study participants, 362 (78.9%) were aware of the AB-PMJAY. Utilization of AB-PMJAY was only 1.3% among the eligible study participants. There was a statistical significance between the category of eligible study, ration card, and employment status with the awareness of the AB-PMJAY. Conclusion Every two out of three rural individuals and three out of every four eligible participants were aware of the AB-PMJAY scheme, while the level of utilization was found to be very low at 1.3%; hence, training of the healthcare workers at the grass-root level, like accredited social health activists (ASHA) and Anganwadi workers (AWW), should be done regularly to improve the connection in the community and for effective utilization of the Ayushman Bharat-PMJAY.
Stochastic Geometric Analysis of the Terahertz (THz)-mmWave Hybrid Network With Spatial Dependence

The Terahertz (THz) band (0.1–10 THz) contains abundant spectrum resources that can offer ultra-high data rates. Despite these potential benefits, the adoption of THz communication has been stagnant until very recently due to the poor penetrability and limited coverage of the THz links. To overcome the aforementioned obstacles and take full advantage of the THz band, we introduced a hybrid network consisting of THz and millimeter-wave (mmWave) nodes deployed within a finite area. Furthermore, the mmWave nodes are spatially distributed by a Poisson Point Process (PPP), whereas the THz nodes are clustered around the mmWave nodes, forming a Poisson Cluster Process (PCP) with the parent process of mmWave tier. We derive the Laplace transform of the interference in a closed form and evaluate the coverage probability (CP) based on the maximum biased power (Max-BRP) association strategy. The proposed framework provides insights into how the spatial dependence between THz and mmWave tier and clustering setting affects network performance. We quantitatively reveal its impact on the network performance. It is revealed that this inter-tier spatial dependence introduces the flexibility of nodes deployment by tuning the scattering variance and the number of nodes per cluster. Furthermore, we use numerical simulation to demonstrate the significant impact of bias ratio, density, and blockage on the CP, indicating the importance of choosing the optimal combination of the parameters.
Function of ALA Content in Porphyrin Metabolism Regulation of Ananas comosus var. bracteatus

Chlorophyll and heme are essential molecules for photosynthesis and respiration, which are competing branches of the porphyrin metabolism pathway. Chlorophyll and heme balance regulation is very important for the growth and development of plants. The chimeric leaves of Ananas comosus var. bracteatus were composed of central photosynthetic tissue (PT) and marginal albino tissue (AT), which were ideal materials for the study of porphyrin metabolism mechanisms. In this study, the regulatory function of ALA content on porphyrin metabolism (chlorophyll and heme balance) was revealed by comparing PT and AT, 5-Aminolevulinic Acid (ALA) exogenous supply, and interference of hemA expression. The AT remained similar in porphyrin metabolism flow level to the PT by keeping an equal ALA content in both tissues, which was very important for the normal growth of the chimeric leaves. As the chlorophyll biosynthesis in AT was significantly inhibited, the porphyrin metabolism flow was directed more toward the heme branch. Both tissues had similar Mg2+ contents; however, Fe2+ content was significantly increased in the AT. The chlorophyll biosynthesis inhibition in the white tissue was not due to a lack of Mg2+ and ALA. A 1.5-fold increase in ALA content inhibited chlorophyll biosynthesis while promoting heme biosynthesis and hemA expression. The doubling of ALA content boosted chlorophyll biosynthesis while decreasing hemA expression and heme content. HemA expression interference resulted in a higher ALA content and a lower chlorophyll content, while the heme content remained at a relatively low and stable level. Conclusively, a certain amount of ALA was important for the stability of porphyrin metabolism and the normal growth of plants. The ALA content appears to be able to regulate chlorophyll and heme content by bidirectionally regulating porphyrin metabolism branch direction.
Schools and emergency feeding in a national crisis in the United Kingdom: subterranean class strategies

Abstract The role of ‘class strategies’ in policy formation is sometimes unseen as plans are unrealised in practice over long periods of historical time. ‘Subterranean class strategies’ are an extension of existing work on class to consider ‘class work’ on policy in the ‘long unenacted’. Using the example of emergency feeding in a national crisis, the stark difference in school meal planning for post-World War 2 emergencies when compared to the COVID-19 crisis is discussed. Through an analysis of archival records, it is shown that ‘subterranean class strategies’ - the devaluation of school catering expertise by the army and the private sector, the lack of co-operation of independent schools, and localisation and privatisation - diminished the role of schools in emergency feeding. The paper concludes by considering how the concept of ‘subterranean class strategies’ could inform work on educational think tanks, privatisation and subsumption, and intersectional areas such as race.
Canonical Wnt Pathway Is Involved in Chemoresistance and Cell Cycle Arrest Induction in Colon Cancer Cell Line Spheroids

The presence of cancer stem cells (CSCs) has been associated with the induction of drug resistance and disease recurrence after therapy. 5-Fluorouracil (5FU) is widely used as the first-line treatment of colorectal cancer (CRC). However, its effectiveness may be limited by the induction of drug resistance in tumor cells. The Wnt pathway plays a key role in the development and CRC progression, but it is not clearly established how it is involved in CSCs resistance to treatment. This work aimed to investigate the role played by the canonical Wnt/β-catenin pathway in CSCs resistance to 5FU treatment. Using tumor spheroids as a model of CSCs enrichment of CRC cell lines with different Wnt/β-catenin contexts, we found that 5FU induces in all CRC spheroids tested cell death, DNA damage, and quiescence, but in different proportions for each one: RKO spheroids were very sensitive to 5FU, while SW480 were less susceptible, and the SW620 spheroids, the metastatic derivative of SW480 cells, displayed the highest resistance to death, high clonogenic capacity, and the highest ability for regrowth after 5FU treatment. Activating the canonical Wnt pathway with Wnt3a in RKO spheroids decreased the 5FU-induced cell death. But the Wnt/β-catenin pathway inhibition with Adavivint alone or in combination with 5FU in spheroids with aberrant activation of this pathway produced a severe cytostatic effect compromising their clonogenic capacity and diminishing the stem cell markers expression. Remarkably, this combined treatment also induced the survival of a small cell subpopulation that could exit the arrest, recover SOX2 levels, and re-grow after treatment.
Formulation and Characterization of a Novel Palm-Oil-Based α-Mangostin Nano-Emulsion (PO-AMNE) as an Antimicrobial Endodontic Irrigant: An In Vitro Study

Aim: To formulate and characterize a palm-oil-in-water-based α-Mangostin nano-emulsion (PO-AMNE) endodontic irrigant, in order to evaluate its antibacterial efficacy against Enterococcus faecalis, Staphylococcus epidermidis, and Candida albicans biofilms, as well as its capacity to remove smear layer. Methods: The solubility of α-Mangostin in various oils was determined and selected, surfactants and co-surfactants were used for the nano-emulsion trial. PO-AMNE was prepared and optimized. The MIC was performed, and the antimicrobial efficacy was estimated against biofilms. The optimized 0.2% PO-AMNE irrigant antimicrobial efficacy in a tooth model was done using colony-forming units. The treated teeth were processed by scanning electron microscopic examination for debris and smear layer removal. An Alamar Blue assay was used to evaluate cell viability. The optimization of the PO-AMNE irrigant was performed using Box–Behnken statistical design. Results: The optimized 0.2% PO-AMNE irrigant was found to have a particle size of 340.9 nm with 0.246 PDI of the dispersed droplets, and a zeta potential (mV) of −27.2 ± 0.7 mV. The MIC values showed that 0.2% PO-AMNE (1.22 ± 0.02) were comparable to 2% CHX (1.33 ± 0.01), and 3.25% NaOCl (2.2 ± 0.09) had the least inhibition for E. faecalis. NaOCl (3.25%) showed the maximum inhibition of S. epidermidis (0.26 ± 0.05), whereas 0.2% PO-AMNE (1.25 ± 0.0) was comparable to 2% CHX (1.86 ± 0.07). For C. albicans, 2% CHX (8.12 ± 0.12) showed the least inhibition as compared to 0.2% PO-AMNE (1.23 ± 0.02) and 3.25% NaOCl (0.59 ± 0.02). The 0.2% PO-AMNE irrigant was then evaluated for its antimicrobial efficacy against the three biofilms, using colony-forming units. The 0.2% PO-AMNE was comparable to both 3.25% NaOCl and 2% CHX in inhibiting the growth of biofilms. The 0.2% PO-AMNE and 17% EDTA eliminated the smear layer with the lowest mean scores (p < 0.001). Finally, 0.2% PO-AMNE was shown to be biocompatible when compared to 17% EDTA, 3.25% NaOCl, and 2% CHX in immortalized oral keratinocyte cells. Conclusion: Overall, the formulated 0.2% PO-AMNE irrigant was an effective antimicrobial and biocompatible which could combat endodontic-infection-related polymicrobial biofilms.
Hierarchical basis preconditioners for first kind integral equations

We study hierarchical basis preconditioners for the h-version Galerkin boundary element method applied to weakly singular and hypersingular integral equations of the first kind. We show that the condition numbers of the preconditioned linear systems are bounded by log2(l/h). Hence, the well known result for finite elementmethods is generalized to boundary integral operators, which are non-local operators.Extensions to non-local refinements are also discussed. Numerical experiments confirmthe theoretical results.
Reduced Loss and Prevention of Substrate Modes with a Novel Coplanar Waveguide Based on Gap Waveguide Technology

The Gap Waveguide technology utilizes an Artificial Magnetic Conductor (AMC) to prevent the propagation of electromagnetic (EM) waves under certain conditions, resulting in various gap waveguide configurations. In this study, a novel combination of Gap Waveguide technology and the traditional coplanar waveguide (CPW) transmission line is introduced, analyzed, and demonstrated experimentally for the first time. This new line is referred to as GapCPW. Closed-form expressions for its characteristic impedance and effective permittivity are derived using traditional conformal mapping techniques. Eigenmode simulations using finite-element analysis are then performed to assess its low dispersion and loss characteristics. The proposed line demonstrates an effective suppression of the substrate modes in fractional bandwidths up to 90%. In addition, simulations show that a reduction of up to 20% of the dielectric loss can be achieved with respect to the traditional CPW. These features depend on the dimensions of the line. The paper concludes with the fabrication of a prototype and validation of the simulation results in the W band (75–110 GHz).