Miracle-dz/UniFAR-FTUs huggingface dataset:
Digital Education in Ophthalmology

Abstract Accessibility to the Internet and computer systems has prompted the gravitation towards digital learning in medicine, including ophthalmology. Using the PubMed database and Google search engine, current initiatives in ophthalmology that serve as alternatives to traditional in-person learning with the purpose of enhancing clinical and surgical training were reviewed. This includes the development of teleeducation modules, construction of libraries of clinical and surgical videos, conduction of didactics via video communication, and the implementation of simulators and intelligent tutoring systems into clinical and surgical training programs. In this age of digital communication, teleophthalmology programs, virtual ophthalmological society meetings, and online examinations have become necessary for conducting clinical work and educational training in ophthalmology, especially in light of recent global events that have prevented large gatherings as well as the rural location of various populations. Looking forward, web-based modules and resources, artificial intelligence–based systems, and telemedicine programs will augment current curricula for ophthalmology trainees.
Safety of SARS-CoV-2 vaccines in patients with chronic myeloid leukemia: a multicenter survey in China

Department of Hematology, Institute of Hematology, West China Hospital of Sichuan University, Chengdu, Sichuan 610041, China; Department of Hematology, Affiliated Cancer Hospital of Zhengzhou University, Henan Provincial Tumor Hospital, Zhengzhou, Henan 450000, China; Department of Hematology, Peking University People’s Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing
Disparities in Access to Cranial Remodeling Orthosis for Deformational Plagiocephaly

Objective Moderate to severe cases of deformational plagiocephaly (DP) may be treated with cranial remolding orthoses (CRO). This study investigated the socioeconomic disparities in access to care for CRO for DP correction. Design This was a retrospective review of medical records from a single CRO company in Connecticut from 2014 to 2020. Methods Demographic variables were collected from all patients. Univariable logistic regressions were used to identify differences for presenting age at consultation, whether CRO was pursued, and length of CRO treatment by insurance payor and household income quartile. Results Of the 5620 patients identified, 4100 (73.0%) received CRO, with 674 (12.0%) receiving a second helmet. Of those receiving CRO, 1536 (37.5%) had Medicaid insurance while 2558 (62.4%) were commercially insured. Patients on Medicaid were 1.30 times more likely to have delayed presentation (P = .017), while patients from the lowest income quartile were 1.26 1.50 (P < .001) and 1.58 (P < .001) times more likely to have a delayed presentation relative to those in the highest and second-highest income quartiles, respectively. Patients in the highest and second-highest income quartiles were also 1.55 (P < .001) and 1.45 (P < .001) more likely, respectively, to receive CRO after consultation than those from the lowest income quartile. Conclusions Lower income and Medicaid-insured patients had delayed presentation for CRO consultation. Those from the lowest income quartile were more likely to never receive CRO than those from wealthier backgrounds. Low socioeconomic status and Medicaid insurance, which can have more restrictive coverage policies for CRO, may result in the delayed treatment of DP.
Millennial Medical Students' Educational Expectations of Anesthesia Clerkships.

Background The unique characteristics of the millennial generation has promulgated changes in the workplace and in academia. A lack of national standards necessitates that anesthesia faculty create educational content for anesthesia clerkships. Assessing expectations before an anesthesia rotation would provide data to accommodate millennial medical students' needs and preferences for learning. Methods A 16-question survey using Qualtrics software was created, with input from millennial medical students, to query preclinical medical students at the Oakland University William Beaumont School of Medicine on their educational expectations of an anesthesia clerkship. Results Seventy-four surveys were completed, with 34 (46%) of 74 from first-year and 40 (54%) of 74 from second-year medical students. Daily feedback (44 [59%] of 74) and written exams (43 [58%] of 74) were preferred methods of evaluation. No lectures, observing in an operating room, and performing procedures on real patients were the preferred format for instruction. Two (23 [31%] or 74) to 3 (33 [45%] of 74) weeks was the preferred duration of an anesthesia rotation. Conclusions This study demonstrates that millennial medical students have preconceived educational expectations of an anesthesia clerkship, and identifies learning preferences that differ from the implemented anesthesia curriculum currently described in the literature.
Experiences of Stress – A Focus Group Interview Study Among Swedish Adolescents During the COVID-19 Pandemic

Adolescence can be a stressful period in life. The period contains challenges associated with the transition from childhood to adulthood (body changes, changes in interpersonal relationships, and identity changes). The aim was to investigate experiences of stress among adolescents in addition to stress related to the COVID-19 pandemic. Focus group interviews (n = 8) were conducted with girls (n = 22) and boys (n = 19) aged 13–15 in southern Sweden. The transcribed interviews were analyzed with qualitative content analysis. Analysis of the collected material resulted in two categories with four sub-categories each of which highlights adolescents’ experiences of stress. The results show that adolescents’ have a variety of experiences of stress, i.e., what they mean are the sources of stress and how stress is manifested. The adolescents experienced how stress was manifested both physically and emotionally. This affected both their sleep and performance. The adolescents reflected on both positive and negative manifestations of stress.
Factors associated with initiation and use of snus among adolescents

Aim: We investigated factors associated with the initiation and continuation of snus use in adolescents in Norway. The associations with adolescents’ own educational plans, the parents’ educational level(s) and tobacco habits were estimated. Methods: In this cross-sectional questionnaire-based study, 1465 patients aged 18–20 years participated. The questionnaire was administered at regular dental examinations in the public dental health service. To assess the association between individual factors and the initiation of tobacco habits, a generalised structural equation model with random effects at the clinic level was used. Binary responses were modelled using multilevel binary logistic regression, while the number of snus boxes used per month was modelled using a multilevel Poisson regression model. Results: Of current (daily and occasional) tobacco users, 85% were snus users, including dual users of both snus and cigarettes. The median age of snus initiation was 16 years. Both parental snus use and smoking were associated with an increased risk of snus initiation, snus use and a higher amount of use. An increased risk of using snus was associated with male gender and with no educational plans or planning for further vocational education. The amount of snus used was higher among current snus users with a prior smoking history and among those planning for further vocational education. Conclusions: These findings may aid in developing and targeting tobacco prevention strategies aimed at young people. Tobacco prevention measures should start at the elementary school level. The strong association with parental tobacco habits underlines the importance of parents’ influence on their children’s tobacco use.
Pressure Distribution and Global Forces on a Bridge Deck Section: Experimental and CFD Analysis of Static Aerodynamic Forces

AbstractTwo different experimental approaches for the evaluation of a bridge deck’s stationary aerodynamic forces are studied in this paper: both wind tunnel measurement of global force and pressure distribution are evaluated on deck sectional models. Advantages and drawbacks of these different approaches are discussed using the results obtained on a simple deck section, specifically chosen to compare the selected methods. Two-dimensional computational fluid dynamics (CFD) simulations have been performed to provide an insight into the differences of the aerodynamic forces measured with the two methods. Specifically, the effect of shear stresses, measurement discretization, and axial correlation of pressures are addressed. In CFD analysis, several turbulence models are tested and discussed using Reynolds-averaged Navier-Stokes (RANS) equations.
ROX index in COVID-19 patients - is it the answer?

As the world stands witness to the havoc caused by the COVID-19 pandemic, the shortage of mechanical ventilators a common peril in the already stressed healthcare system around the globe. HFNC (high flow nasal cannula) is being used now in most ICU settings to prevent ventilator requirements in patients with type 1 respiratory failure. It allows high flows and fractions of inspired oxygen (FiO2) at a more physiological level of temperature and humidity. The mechanism of HFNC includes small pliable nasal prongs which increase the comfort of the patient, humidification facilitates expectoration of secretions, washout of nasopharyngeal dead space that improves the efficiency of ventilation, high flow rates that help in reliable delivery of FiO2, and a small continuous positive airway pressure effect. The prediction of the success of HFNC is recently been done by using the ROX index. ROX index is defined as the ratio of pulse oximetry/fraction of inspired oxygen (SpO2/FiO2) to respiratory rate (RR). This index has been used in emergency [1] to predict intubation as well in patients with pneumonia who are having acute respiratory failure [2]. The studies on the ROX index have measured different time intervals post-initiation of HFNC and suggested either 6 hours or 12 hours value as the most sensitive predictor for the probability of intubation [2, 3]. Recently a new index modified ROX has been devised in a study. Modified ROX is defined as (respiratory rate oxygenation-heart rate) the ratio of ROX index over HR (beats/min) and multiplying by a factor of 100 [4]. This study showed that that modified ROX helped in the early identification of HFNC failure, as early as 1–2 hours. WHY? — a scoring system such as ROX is required in an emergency or critical care setting to make it easier for the physician to decide on the institution of mechanical ventilation. It has been seen in multiple studies [5, 6] that late failure of NIV has lead to adverse outcomes and increased mortality, the reason being increased disease progression with increased respiratory rate. During NIV trial in severe respiratory disease, if high driving pressures are used for ventilation; lung injury occurs due to over-distension of the healthy lung. This phenomenon is known as self-inflicted lung injury. Patient-ventilator dyssynchrony also plays a major role in lung injury. There are not many studies comparing late HFNC failure (> 48 hours) with mortality. The study done by B. J. Kang et al. [7] showed late HFNC failure was associated with higher mortality when compared to early HFNC failure. The reason for the same being that delayed intubation can lead to further disease progression causing respiratory muscle fatigue and cardiac dysfunction which cumulatively lead to increased mortality in ICU. Hence from these findings, we can analyze the importance of an objective prediction score which will help in the early identification of HFNC failure so that mortality can be reduced.
Frailty and In-Hospital Mortality Risk Using EHR Nursing Data

Purpose The purpose of this study was to evaluate four definitions of a Frailty Risk Score (FRS) derived from EHR data that includes combinations of biopsychosocial risk factors using nursing flowsheet data or International Classification of Disease, 10th revision (ICD-10) codes and blood biomarkers and its predictive properties for in-hospital mortality in adults ≥50 years admitted to medical-surgical units. Methods In this retrospective observational study and secondary analysis of an EHR dataset, survival analysis and Cox regression models were performed with sociodemographic and clinical covariates. Integrated area under the ROC curve (iAUC) across follow-up time based on Cox modeling was estimated. Results The 46,645 patients averaged 1.5 hospitalizations (SD = 1.1) over the study period and 63.3% were emergent admissions. The average age was 70.4 years (SD = 11.4), 55.3% were female, 73.0% were non-Hispanic White (73.0%), mean comorbidity score was 3.9 (SD = 2.9), 80.5% were taking 1.5 high risk medications, and 42% recorded polypharmacy. The best performing FRS-NF-26-LABS included nursing flowsheet data and blood biomarkers (Adj. HR = 1.30, 95% CI [1.28, 1.33]), with good accuracy (iAUC = .794); the reduced model with age, sex, and FRS only demonstrated similar accuracy. The poorest performance was the ICD-10 code-based FRS. Conclusion The FRS captures information about the patient that increases risk for in-hospital mortality not accounted for by other factors. Identification of frailty enables providers to enhance various aspects of care, including increased monitoring, applying more intensive, individualized resources, and initiating more informed discussions about treatments and discharge planning.
High-yield synthesis of CsPbBr3 nanoparticles: diphenylphosphine as a reducing agent and its effect in Pb-seeding nucleation and growth

Based on the reported nucleation mechanisms for CsPbX3 and II–VI/IV–VI quantum dots, CsPbBr3 nanoparticles with a higher reaction-yield (up to 393% mass-increment) were synthetized by the hot-injection method. The introduction of diphenylphosphine (DPP) as a reducing agent improved nanoparticle nucleation and growth, giving out evidence for Pb-seeding in CsPbBr3 nanoparticles formation. Additionally, a clear influence of the DPP in a CsPbBr3-Cs4PbBr6 incomplete phase transformation was observed, marked by the appearance of several PbBr2 nanoparticles. This indicated the need for an improved ratio between the stabilizing agents and the precursors, due to the increased number of nucleation sites produced by DPP. The resulting CsPbBr3 nanoparticles showed high quality, as they displayed 70%–90% photoluminescence quantum yield; narrow size distribution with an average nanoparticle size of ∼10 nm; and the characteristic cubic morphology reported in previous works. This increment in CsPbBr3 nanoparticles’ reaction yield will contribute to making them a more attractive option for different optoelectronic applications.
Association between c-Myc Expression with Clinicopathological Features in T And NK Cell Lymphomas

Background: c-Myc has become significantly involved in aggressive B-cell non Hodgkin lymphoma (NHL), but little is known about its importance in T and NK cell NHL (TNKcNHLs) in association with prognostic factors. The study is to investigate the significance of c-Myc expression with clinicopathological features of TNKcNHLs patients. Methodology: A cross-sectional study of 32 archived tissue blocks of TNKcNHLs were immunohistochemically stained with c-Myc. The results were microscopically evaluated and statistically analysed to examine the association between the clinicopathological data with the c-Myc expression. Results: c-Myc protein expressions were detected in 25/32 (78.1%) cases. The median age was 38-years. Malay ethnicity (92.0%) with 21 males and 11 females. c-Myc expressions were seen in T lymphoblastic lymphoma (20%), ALK-positive ALCL (16%) ,PTCL,NOS (16%), extra nodal NK/T-cell lymphoma, nasal type (12%), extra-nodal involvement (78.1%), elevated serum LDH (83.3%) and high ECOG performance status (82.4%). However, no statistical significant of c-Myc in association with the clinicopathological parameters (p > 0.05). Conclusion: There was no statistically significant association of clinicopathological parameters and histological subtypes of TNKcNHLs contributed by small samples tested. However, the attribution of c-Myc in this disease should be further explored.
Rich Phase Separation Behavior of Biomolecules

Phase separation is a thermodynamic process leading to the formation of compositionally distinct phases. For the past few years, numerous works have shown that biomolecular phase separation serves as biogenesis mechanisms of diverse intracellular condensates, and aberrant phase transitions are associated with disease states such as neurodegenerative diseases and cancers. Condensates exhibit rich phase behaviors including multiphase internal structuring, noise buffering, and compositional tunability. Recent studies have begun to uncover how a network of intermolecular interactions can give rise to various biophysical features of condensates. Here, we review phase behaviors of biomolecules, particularly with regard to regular solution models of binary and ternary mixtures. We discuss how these theoretical frameworks explain many aspects of the assembly, composition, and miscibility of diverse biomolecular phases, and highlight how a model-based approach can help elucidate the detailed thermodynamic principle for multicomponent intracellular phase separation.
Humility, Personality, and Psychological Functioning

As part of the shift to a more positive psychology, researchers have demonstrated a relatively new and intense fascination with humility. Following a discussion of this construct and its correlates, we investigate how humility relates to personality dimensions, anxiety and depression, love of life and happiness, and self-efficacy in two samples—college students and adult Mturk workers. In both studies, we used the Dual Dimension Humility Scale, a measure that does not conflate the construct with honesty. Among students (N = 399), aspects humility correlated with dimensions of personality (more conscientiousness and openness, and less agreeableness and neuroticism), less depression, more love of life and happiness, and stronger social self-efficacy. Although fewer associations were found, overall, among adults (N = 509), aspects of humility correlated with dimensions of personality, less anxiety, and some dimensions of psychological well-being. The most unique contributions of this study include linking humility with college students’ love of life and self-efficacy, and with adults’ well-being. We conclude with a discussion of ideas for future research and potential applications to boost humility.
A practical SPICE model based on the physics and characteristics of realistic single-electron transistors

A practical model for a single-electron transistor (SET) was developed based on the physical phenomena in realistic Si SETs, and implemented into a conventional circuit simulator. In the proposed model, the SET current calculated by the analytic model is combined with the parasitic MOSFET characteristics, which have been observed in many recently reported SETs formed on Si nanostructures. The SPICE simulation results were compared with the measured characteristics of the Si SETs. In terms of the bias, temperature, and size dependence of the realistic SET characteristics, an extensive comparison leads to good agreement within a reasonable level of accuracy. This result is noticeable in that a single set of model parameters was used, while considering divergent physical phenomena such as the parasitic MOSFET, the Coulomb oscillation phase shift, and the tunneling resistance modulated by the gate bias. When compared to the measured data, the accuracy of the voltage transfer characteristics of a single-electron inverter obtained from the SPICE simulation was within 15%. This new SPICE model can be applied to estimating the realistic performance of a CMOS/SET hybrid circuit or various SET logic architectures.
ASSESSING THE IMPACT OF HAPTIC PERIPHERAL DISPLAYS FOR UAV OPERATORS

Abstract : A future implementation of unmanned aerial vehicle "UAV" operations is having a single operator control multiple UAVs. The research presented here explores possible avenues of enhancing audio cues of UAV interfaces for this futuristic control of multiple UAVs by a single operator. This project specifically evaluates the value of continuous and discrete audio cues as indicators of course deviations or late arrivals to targets for UAV missions. It also looks at the value of the audio cues in single and multiple UAV scenarios. To this end, an experiment was carried out on the Multiple Autonomous Unmanned Vehicle Experimental "MAUVE" test bed developed in the Humans and Automation Laboratory at the Massachusetts Institute of Technology with 44 military participants. Specifically, two continuous audio alerts were mapped to two human supervisory tasks within MAUVE. One of the continuous audio alerts, an oscillating course deviation alert was mapped to UAV course deviations which occurred over a continual scale. The other continuous audio alert tested was a modulated late arrival alert which alerted the operator when a UAV was going to be late to a target. In this case the continuous audio was mapped to a discrete event in that the UAV was either on time or late to a target. The audio was continuous in that it was continually on and alerting the participant to the current state of the UAV. It either was playing a tone indicating the UAV was on time to a target or playing a tone indicating the UAV was late to a target. These continuous alerts were tested against more traditional single beep alerts which acted as discrete alerts. The beeps were discrete in that when they were used for monitoring course deviations a single beep was played when the UAV got to specific threshold off of the course or for late arrivals a single beep was played when the UAV became late.
The search for Schizosaccharomyces fission yeasts in environmental metatranscriptomes

Fission yeast is an important model organism in evolutionary genetics and cell biology research. Nevertheless, most research is limited to a single laboratory strain and knowledge of its natural occurrence is limited, which reduces our understanding of its life history and hinders isolation of new strains from nature. Understanding the natural diversity of fission yeast can provide insight into its genetic and phenotypic diversity and the evolutionary processes that shaped these. Here, we aimed to identify candidate natural habitats of fission yeasts by searching through a large collection of publicly available environmental metatranscriptomic datasets. Using a custom pipeline, we processed over 13,000 NCBI SRA accessions, from a wide range of 34 different environmental categories. Overall, we found a very low abundance of putative yeast transcripts, with most fission yeast signatures coming from the categories of ‘food’ and ‘terrestrial arthropods’. Additionally, a signal could be found in a variety of marine and fresh aquatic habitats. Our results do not provide a conclusive answer on the natural habitat of fission yeasts, but our analysis further narrows the range of locations where fission yeasts naturally occur.