Miracle-dz/UniFAR-FTUs huggingface dataset:
Characterisation of body size phenotypes in a middle-aged Maltese population

Abstract Obesity is increasingly recognised as being a heterogeneous disease. Some obese individuals may present a metabolically healthy profile (metabolically healthy obese (MHO)), while some normal weight individuals exhibit an adverse cardiometabolic phenotype (metabolically unhealthy normal weight individuals (MUHNW)). The objectives of the present study were to examine the prevalence and associated characteristics of the different body composition phenotypes within a Maltese cohort. This was a cross-sectional analysis involving 521 individuals aged 41 ± 5 years. The metabolically unhealthy state was defined as the presence of ≥2 metabolic syndrome components (NCEP-ATPIII parameters), while individuals with ≤1 cardiometabolic abnormalities were classified as metabolically healthy. Overall, 70 % of the studied population was overweight or obese and 30⋅7 % had ≥2 cardiometabolic abnormalities. The prevalence of MHO and MUHNW was 10⋅7 and 2⋅1 %, respectively. Individuals with the healthy phenotype were more likely to consume alcohol, participate in regular physical activity and less likely to be smokers. While the MHO phenotype had similar values for waist, hip and neck circumferences, waist–hip ratio and insulin resistance when compared with MUHNW individuals, there was a lower proportion of MHO subjects having a high fasting plasma glucose, hypertriglyceridaemia or low HDL-C when compared with the unhealthy lean individuals. A high prevalence of the metabolically unhealthy phenotype was observed in this relatively young population which may result in significant future cardiovascular disease burden if timely assessment and management of modifiable risk factors are not implemented. Furthermore, the present study suggests that the MHO phenotype is not totally benign as previously thought.
Cultural Mediation and Gatekeeping in Dubbing of American Feature Films on Iranian Television

ABSTRACT This qualitative study investigated mediation and censorship in the Persian dubbing of a sample of American feature films broadcast on Iranian national television to get insights into the details of these gatekeeping practices in recent years. The results revealed that many verbal and nonverbal instances relating to sexuality, Christian rituals and symbols, violence, insults and profanity, out of marriage relationships, and sensitive political references were identified inappropriate and edited out in the dubbed versions on account of religious, socio-cultural, and political considerations. The achieved results of the study have immediate pedagogical applications for dubbing practitioners, translators, students, and educators.
Impact of an Innovative Video Demonstration on Perceptions and Attitudes Toward McDonald’s Product Quality

ABSTRACT In spite of product quality improvements, young adults are turning away from Quick Service Restaurant chains in pursuit of a healthier diet and lifestyle. Restaurants struggle to communicate improvements to this skeptical audience that is also shifting away from traditional media. An innovative video demonstration is introduced as a form of online advertising that may break through to young adults and influence their perceptions and attitudes. This study tests whether this approach can influence young adult perceptions and attitudes toward product quality for McDonald’s restaurants in the USA. Results show that not only can this type of video influence perceptions of product quality, but their influence can also extend to attitudes toward the restaurant experience and behavioral intentions overall. Results respond directly to several questions in the communications literature regarding online video advertising and its effectiveness. Results also provide guidance to marketing practitioners on what may be effective message and creative strategies.
Teacher anxiety and technology change: a review of the literature

ABSTRACT Teachers are faced with fast-paced changes in educational practice and expectations as technology innovation continues over time. This rate of change may contribute to an increase in anxiety that impacts effective technology integration in the classroom. The authors examined peer-reviewed literature from 2008 to 2018 on teacher anxiety from technological change to gain a deeper understanding of the current status and direction of this topic from academic research communities. An in-depth analysis was conducted of 45 articles that focused on these variables in K–12 and higher education teacher populations. Articles were coded for logistical and thematic differences. Four themes emerged: (a) teacher conceptual change; (b) anxiety’s connection with other variables found to influence technology adoption; (c) emotion’s place within existing theoretical models; and (d) emotion’s influence on teacher adaptability.
Trusted audit with untrusted auditors: A decentralized data integrity Crowdauditing approach based on blockchain

Edge computing emerges as an alternative to cloud computing in the scenarios where the end devices require lower latency and faster access speeds. Edge nodes are deployed at the proximity of the end devices to reduce response time. On the other hand, the edge nodes are usually owned by small organizations that have limited operations and maintenance capabilities. Data on the edge may be easily damaged, due to external attacks or internal hardware failures. Therefore, it is essential to verify data integrity in edge computing. However, edge environment requires a different trust model compared with other computing and storage paradigm. Besides, compared with cloud storage, edge storage is decentralized and storage service participants may pose greater internal and external threats. This paper proposes a blockchain‐based intelligent crowdsourcing audit approach (Crowdauditing) to achieve on‐chain and off‐chain credibility of audit results. The model relies on an untrusted auditor committee from the crowd to audit data integrity and uses smart contracts as the core of the intelligent system to ensure the reliability of result submission, the accuracy of the result judgment, and reasonable punishments and rewards. Specifically, an unbiased selection algorithm is proposed to achieve fairness during the auditor committee construction. An innovative two‐stage submission strategy is proposed to ensure that the auditor committee can reach a consensus on the off‐chain audit results. An incentive mechanism is carefully designed to force auditors providing audit services honestly to maximize their own rewards. Moreover, we modeled that as a game of n players, which proves the reliability of the result. Finally, we implement a prototype of Crowdauditing based on smart contracts. The extensive experimental results demonstrate the effectiveness of Crowdauditing.
Assessment and selection of smart agriculture solutions using an information error‐based Pythagorean fuzzy cloud algorithm

Smart agriculture can enhance agricultural production efficiency, improve the ecological environment, and realize the sustainable development of agriculture. Many countries and companies are working hard to develop or introduce smart agricultural solutions. Because of the shackles of traditional agricultural management methods and fierce competition with a variety of different solutions, it is a difficult task for enterprises to select and implement smart agricultural solutions smoothly. Hence, enterprises must assess alternative solutions and select a feasible solution in advance. This study drew a novel assessment and selection for smart agriculture solutions using an information error‐based Pythagorean fuzzy cloud algorithm. First, an evaluation index system built on smart agriculture solutions was constructed from four aspects. Then, a new concept of Pythagorean fuzzy clouds was defined to express the evaluation information for each indicator. Simultaneously, the Pythagorean fuzzy cloud weighted Bonferroni mean (PFCWBM) operator was developed to aggregate the assessment information of multiple indicators. Next, an assessment and selection decision framework for smart agriculture solutions based on the PFCWBM operator was presented. In addition, an example was given to illustrate the effectiveness of the proposed algorithm. Finally, a discussion was conducted to verify the superiority of our approach. The results showed that our algorithm can characterize and evaluate complex information and has high sensitivity and environmental adaptability.
Examining disease boundaries: Genetics of myelodysplastic/myeloproliferative neoplasms

Myelodysplastic/myeloproliferative neoplasms (MDS/MPN) are clonal myeloid malignancies that are characterized by dysplasia resulting in cytopenias as well as proliferative features such as thrombocytosis or splenomegaly. Recent studies have better defined the genetics underlying this diverse group of disorders. Trisomy 8, monosomy 7, and loss of Y chromosome are the most common cytogenetic abnormalities seen. Chronic myelomonocytic leukemia (CMML) likely develops from early clones with TET2 mutations that drive granulomonocytic differentiation. Mutations in SRSF2 are common and those in the RAS‐MAPK pathway are typically implicated in disease with a proliferative phenotype. Several prognostic systems have incorporated genetic features, with ASXL1 most consistently demonstrating worse prognosis. Atypical chronic myeloid leukemia (aCML) is most known for granulocytosis with marked dysplasia and often harbors ASXL1 mutations, but SETBP1 and ETNK1 are more specific to this disease. MDS/MPN with ring sideroblasts and thrombocytosis (MDS/MPN‐RS‐T) most commonly involves spliceosome mutations (namely SF3B1) and mutations in the JAK‐STAT pathway. Finally, MDS/MPN‐unclassifiable (MDS/MPN‐U) is least characterized but a significant fraction carries mutations in TP53. The remaining patients have clinical and/or genetic features similar to the other MDS/MPNs, suggesting there is room to better characterize this entity. Evolution from age‐related clonal hematopoiesis to MDS/MPN likely depends on the order of mutation acquisition and interactions between various biologic factors. Genetics will continue to play a critical role in our understanding of these illnesses and advancing patient care.
China’s challenge to the global commons: compliance, contestation, and subversion in the maritime and cyber domains

It is often predicted that rising powers such as China will seek to reshape the international order as they gain influence. Drawing on comparative analysis of the maritime and cyber domains, this article argues that China poses a challenge to the global commons because its actions reflect a pragmatic focus on national interest that that disrupts more collaborative conceptions of their governance. However, instead of directly rejecting existing regimes, China has pursued a mixed strategy of complying when these regimes confer benefits and employing contestation or subversion when they conflict with its strategic aims. In particular, China has used contestation and subversion to push for the enclosure of the maritime and cyber domains, extending ideas of sovereignty and territoriality to them to varying extents. While the relatively well-institutionalized nature of maritime governance has limited China’s focus to the application of specific rules in areas where it prioritizes sovereign control, the embryonic status of the cyber regime has enabled China to call into question the fundamental definition of cyberspace as a global common. Subversion has also allowed China to accomplish strategic goals through ‘gray zone’ tactics, resulting in increased conflict below the level of war in both domains.
Molecular insights into RNA recognition and gene regulation by the TRIM-NHL protein Mei-P26

This study provides molecular insights into RNA target recognition by the TRIM-NHL protein Mei-P26 that functions in Drosophila ovarian germline stem cell maintenance, oogenesis, and spermatogenesis. The TRIM-NHL protein Meiotic P26 (Mei-P26) acts as a regulator of cell fate in Drosophila. Its activity is critical for ovarian germline stem cell maintenance, differentiation of oocytes, and spermatogenesis. Mei-P26 functions as a post-transcriptional regulator of gene expression; however, the molecular details of how its NHL domain selectively recognizes and regulates its mRNA targets have remained elusive. Here, we present the crystal structure of the Mei-P26 NHL domain at 1.6 Å resolution and identify key amino acids that confer substrate specificity and distinguish Mei-P26 from closely related TRIM-NHL proteins. Furthermore, we identify mRNA targets of Mei-P26 in cultured Drosophila cells and show that Mei-P26 can act as either a repressor or activator of gene expression on different RNA targets. Our work reveals the molecular basis of RNA recognition by Mei-P26 and the fundamental functional differences between otherwise very similar TRIM-NHL proteins.
Functional network topography of the medial entorhinal cortex

Significance The investigation of the topographic organization of spatially coding cell types in the medial entorhinal cortex (MEC) has so far been held back by the lack of appropriate tools that enable the precise recording of both the anatomical location and activity of large populations of cells while animals forage in open environments. In this study, we use the newest generation of head-mounted, miniaturized two-photon microscopes to image grid, head-direction, border, as well as object-vector cells in MEC and neighboring parasubiculum within the same animals. The majority of cell types were intermingled, but grid and object-vector cells exhibited little overlap. The results have implications for network models of spatial coding. The medial entorhinal cortex (MEC) creates a map of local space, based on the firing patterns of grid, head-direction (HD), border, and object-vector (OV) cells. How these cell types are organized anatomically is debated. In-depth analysis of this question requires collection of precise anatomical and activity data across large populations of neurons during unrestrained behavior, which neither electrophysiological nor previous imaging methods fully afford. Here, we examined the topographic arrangement of spatially modulated neurons in the superficial layers of MEC and adjacent parasubiculum using miniaturized, portable two-photon microscopes, which allow mice to roam freely in open fields. Grid cells exhibited low levels of co-occurrence with OV cells and clustered anatomically, while border, HD, and OV cells tended to intermingle. These data suggest that grid cell networks might be largely distinct from those of border, HD, and OV cells and that grid cells exhibit strong coupling among themselves but weaker links to other cell types.
Structure of the Shaker Kv channel and mechanism of slow C-type inactivation

Voltage-activated potassium (Kv) channels open upon membrane depolarization and proceed to spontaneously inactivate. Inactivation controls neuronal firing rates and serves as a form of short-term memory, and is implicated in various human neurological disorders. Here, we use high-resolution cryo-electron microscopy and computer simulations to determine one of the molecular mechanisms underlying this physiologically crucial process. Structures of the activated Shaker Kv channel and of its W434F mutant in lipid bilayers demonstrate that C-type inactivation entails the dilation of the ion selectivity filter, and the repositioning of neighboring residues known to be functionally critical. Microsecond-scale molecular dynamics trajectories confirm these changes inhibit rapid ion permeation through the channel. This long-sought breakthrough establishes how eukaryotic K+ channels self-regulate their functional state through the plasticity of their selectivity filters. One-Sentence Summary Structures of the Shaker Kv channel reveal the mechanism of slow C-type inactivation involves dilation of the selectivity filter.
Comparative analysis of genome-encoded viral sequences reveals the evolutionary history of flavivirids (family Flaviviridae)

The flavivirids (family Flaviviridae) are a group of positive-strand RNA viruses that pose serious risks to human and animal health on a global scale. Here we use flavivirid-derived DNA sequences, identified in animal genomes, to reconstruct the long-term evolutionary history of family Flaviviridae. We demonstrate that flavivirids are >100 million years old and show that this timing can be combined with dates inferred from co-phyletic analysis to produce a cohesive overview of their evolution, distribution and diversity wherein the main flavivirid subgroups originate in early animals and broadly co-diverge with major animal phyla. In addition, we reveal evidence that the ‘classical flaviviruses’ of vertebrates, most of which are transmitted via blood-feeding arthropod vectors, originally evolved in hematophagous arachnids and later acquired the capacity to be transmitted by insects. Our findings imply that the biological properties of flavivirids have been acquired gradually over the course of animal evolution. Thus, broad-scale comparative analysis will likely reveal fundamental insights into their biology. We therefore published our results via an open, extensible, database (Flavivirid-GLUE), which we constructed to facilitate the wider utilisation of genomic data and evolution-related domain knowledge in flavivirid research.
Phosphate-Solubilizing Bacterium Acinetobacter pittii gp-1 Affects Rhizosphere Bacterial Community to Alleviate Soil Phosphorus Limitation for Growth of Soybean (Glycine max)

Phosphorus (P) availability is a major restriction to crop production, and phosphate-solubilizing bacteria (PSBs) in soils are responsible for P turnover. However, it remains unknown whether the application of PSB can facilitate both inorganic and organic P transformation and enhance function of plant rhizosphere bacteria. In this study, we applied Illumina MiSeq sequencing, plate-colony counting, quantitative PCR, and multiple ecological analyses. We found that the inoculation of PSB Acinetobacter pittii gp-1 significantly promoted the growth of soybean represented by better vegetation properties (e.g., plant height and root P) and increased activities of phosphatase (4.20–9.72 μg/g/h) and phytase (0.69–1.53 μmol/g/day) as well as content of indole acetic acid (5.80–40.35 μg/g/h). Additionally, the application of strain A. pittii gp-1 significantly increased abundances of both inorganic and organic P-cycling-related genes (i.e., phoD, bpp, gcd, and pstS). More importantly, the application of A. pittii gp-1 could increase the function represented by P-cycling-related enzymes (e.g., phosphotransferase) of rhizosphere bacterial community based on functional profiling. To our knowledge, this is the first report that the application of PSB A. pittii promotes inorganic and organic P utilization and increases the function of rhizosphere bacterial community. Therefore, the PSB A. pittii gp-1 could be a good candidate for the promotion of soybean growth.
Applications of Multi-omics Approaches for Exploring the Molecular Mechanism of Ovarian Carcinogenesis

Ovarian cancer ranks as the fifth most common cause of cancer-related death in females. The molecular mechanisms of ovarian carcinogenesis need to be explored in order to identify effective clinical therapies for ovarian cancer. Recently, multi-omics approaches have been applied to determine the mechanisms of ovarian oncogenesis at genomics (DNA), transcriptomics (RNA), proteomics (proteins), and metabolomics (metabolites) levels. Multi-omics approaches can identify some diagnostic and prognostic biomarkers and therapeutic targets for ovarian cancer, and these molecular signatures are beneficial for clarifying the development and progression of ovarian cancer. Moreover, the discovery of molecular signatures and targeted therapy strategies could noticeably improve the prognosis of ovarian cancer patients.
Effects of Appearance- and Performance-Enhancing Drugs on Personality Traits

Appearance- and performance-enhancing drugs (APEDs) are commonly used by adolescents and young adults in an effort to improve not only athletic performance but also physical and mental efficiency and sexual appearance. The rationale for using these drugs is grounded in the perceived importance of external appearance, the quest for health and youth, and the urge to boost one's sexual performances. Although APED users tend to be quite moderate overall, some specific subpopulations can display pathological use associated with high-risk behaviors. A wide and diverse range of APEDs is now easily accessible to almost anyone through backdoor online avenues. Common APEDs include anabolic–androgenic steroids, non-steroidal anabolics, anorectics, diuretics and ergo/thermogenics, nootropics or “cognition enhancers,” licit and illicit psychostimulants, and finally, sexual enhancers. The use of APEDs appears linked to several psychopathological disorders of unclear prevalence, e.g., body image disorders and eating disorders, perfectionism, but also depression and loneliness. The role of personality traits related to APED use has been investigated in adolescents and young adults, in elite and amateur athletes, and in chemsexers and associated with the above-reported personality traits. The studies herein analyzed show that APED consumption in the general population is quickly growing into a public health concern. It is therefore essential to launch prevention and intervention projects aimed at promoting safe instrumental use of the body, not only in sports disciplines but also among the general population, and to promote psychological aid procedures for people with substance use issues, depression and anxiety, and body image disorders.
Video Production and Distribution Platform in Swiss Sports Teams: An Analysis of Acceptance and Willingness to Pay

Swisscom Asport (“Asport”) has set itself the target of covering the entire video process from production to distribution. Its services should be affordable not only for professional sports clubs but also for their amateur counterparts. Despite limited resources, clubs want to increase their attractiveness through new technologies and meet members' needs. This paper examines the factors that lead to the acceptance of Asport services by sports clubs. In addition, the willingness to pay for these services is evaluated. Pricing is critical to success in innovation and also because of the limited financial resources of sports clubs. Based on the literature research, a conceptual model was developed based on the unified theory of acceptance and use of technology model (UTAUT), tested using an online survey of Swiss amateur football clubs, and evaluated using regression analysis. The study findings show that social environment exerts the strongest influence on behavioral intention, defined as “acceptance” in this paper. Furthermore, the two independent variables, performance expectancy and effort expectancy, have a significant effect on user acceptance. In contrast to the original model (UTAUT), this paper demonstrates the direct influence of attitude to use. Of the independent variables, facilitating conditions have an additional effect on attitude to use. The results demonstrate that it is not acceptance but attitude to use that influences willingness to pay. An in-depth evaluation of willingness to pay shows that the optimal price point is 83.3% lower than the price offered by the company; however, there are budget-dependent variations in the assessment.