Miracle-dz/UniFAR-FTUs huggingface dataset:
Full Review Spanish guidelines for the management of autosomal dominant polycystic kidney disease*

Autosomal dominant polycystic kidney disease (ADPKD) is the most frequent cause of genetic renal disease and accounts for 6 – 10% of patients on renal replacement therapy (RRT). Very few prospective, randomized trials or clinical studies address the diagnosis and management of this relatively frequent disorder. No clinical guidelines are available to date. This is a consensus statement presenting the recommendations of the Spanish Working Group on Inherited Kidney Diseases, which were agreed to following a literature search and discussions. Levels of evidence found were C and D according to the Centre for Evidence-Based Medicine (University of Oxford). The recommendations relate to, among other topics, the use of imaging and genetic diagnosis, management of hypertension, pain, cyst infections and bleeding, extra-renal involvement including polycystic liver disease and cranial aneurysms, management of chronic kidney disease (CKD) and RRT and management of children with ADPKD. Recommendations on speci ﬁ c ADPKD therapies are not provided since no drug has regulatory approval for this indication.
Effect of moringa leaf meal and season on blood and hormonal profile of the pearl guinea fowl ( Numida )

This study was undertaken to determine the effect of moringa leaf meal and season on blood and hormonal profile of the Pearl Guinea fowl ( Numida meleagris ) in the Middle belt of Ghana. Thirty-two (32) males and one hundred and twenty-eight (128) female Pearl Guinea fowls aged one-day-old were used for the study. A 3 x 4 factorial experimental design was used for the experiment. Data collected were analyzed using General Linear Model (GLM) procedure of Statistical Analysis System (SAS for Windows, version 7) and means were separated by the probability of difference (PDIFF) procedure of SAS (2008). Mean cell volume was highest (175.39 fl) among Guinea fowls fed with diet containing 12 % moringa leaf meal level. Guinea fowls fed with diet containing 15 % moringa leaf meal had the highest (3.44 x10 12 /L ) red blood cells production. Eosinophil level was highest (3.95 x10 12 /L ) among Guinea fowls fed with diet containing 9 % moringa leaf meal. Birds fed with the moringa diets recorded the highest (P= 0.022) WBC values as compared to the control diet. Triglycerides, high density lipoprotein and low-density lipoprotein levels increased (P<0.05) with increasing levels of dietary moringa leaf meal in the diet. The highest (P= 0.0025) level of progesterone was observed among birds fed with diet containing 12 and 15 % moringa leaf meal inclusion levels. The level of sodium was highest (166.69 nmol/l) among Guinea fowls fed with diet containing 12 % moringa leaf meal. The major and minor rainy seasons recorded the highest (P<0.05) mean cell hemoglobin, red blood cells, albumin and oestrogen levels. Platelets, follicle stimulating hormone, luteinizing hormone, prolactin and chlorine levels were highest (P<0.05) in the dry season while basophil level was highest in the major rainy season. Cholesterol, triglycerides, high density lipoprotein, low density lipoprotein and potassium levels were highest (P<0.05) in the major rainy season. This study concludes that feeding Guinea fowls with moringa leaf meal had positive effect on some haematological, biochemical and hormonal parameters.
An Early Warning System Of Life Insurance Companies Distress In Indonesia

This study is intended to acknowledge the determining factors of financial distress in insurance companies in Indonesia so as to serve as an early warning system for insurance companies. The objects of this study are insurance companies registered in Financial Services Authority (Otoritas Jasa Keuangan – OJK) in Indonesia between 2015-2019. Purposive sampling was employed to determine the sample, resulted in 13 companies qualified for the criteria. The result of Logistic Regression shows that surplus change had a significant positive effect on the probability of the company to experience financial distress, while the while premium growth and firm size have a significant negative effect. Other variables, namely claim expense, liquidity, solvency margin and RBC did not have a significant effect on the probability of a company's financial distress. The results of this study have implications for insurance companies in Indonesia, in terms of reducing changes in surplus, increasing premium growth and firm size.
Quality evaluation of bamboo dietary fibre enriched paneer during storage

Bamboo shoot is a functional food due to the presence of biochemical components like dietary fibre, polyphenols and sterols. Therefore, there exists a great opportunity especially, for the extraction of dietary fibre from bamboo shoots and its utilization in food products as therapeutic agent. The bamboo dietary fibre extracted from the shoots of Dendrocalamus hamiltonii was evaluated for chemical characteristics and used for incorporation in paneer. Fibre of various sources is added to dairy products because of its water-holding capacity and its ability to increase the production yield, reduce the lipid retention, reduce syneresis, improve textural properties and structure, and reduce caloric content by acting as a bulking agent. The bamboo dietary was added at 0% (Paneer without enrichment), 0.5, 1.0, 1.5, 2.0 and 2.5% level to the milk. The prepared paneer with different treatments were evaluated for various quality attributes. Paneer with 2.5% bamboo dietary fibre was found to be the best among the treatments with moisture content of 50.23%, protein (15.71%), total dietary fibre (1.51%), titratable acidity as% lactic acid (0.21%) and pH (5.85).
EFFECT OF PHYTOGENES (THYMOL AND TRANS-CINNAMALDHYDE) ON GROWTH PERFORMANCE AND CECAL BACTERIAL POPULATIONS IN BROILERS

A 35-d trial was conducted to study the effect of phytogenic additives on growth performance and cecal bacterial populations of broilers. The feeding program consisted of a starter diet until 21-d and a grower diet until 35-d. There were 4 treatment groups: control, 50g EO (essential oil)/ ton, 100g EO/ton and 150g EO/ton. Slight non significant improvements have been observed for body weight, weight gain, feed intake and feed conversion ratio in the starter stage when birds fed diets contained 50g EO/ton. In both grower stage and through out the entire period of growth study no differences in growth parameters have been observed when birds fed diets contained 100g EO/ton and those fed the control diet. The worst performance has been observed by the birds fed diets contained 150 EO/ton through the whole stages. Yet, in general, there were no significant difference in growth performance between birds fed the control diet and those fed diets supplemented with EO. No mortality occurred during the whole period of the growth study. Using a commercial blend from thymol and trans-cinnamaldehyde revealed a disparate impact on cecal microflora population. Yet, this was not reflected on the bird growth performance. This may be referred to the balanced diet and controlled condition under which the trial was conducted. The present data suggest, further investigation should focus on the mechanism of EO, the ratio between components of the blend and their effect on bird performance under uncontrolled conditions such as (heat stress, unbalanced diet ….etc.) by increasing levels of EO.
Mice 2 NZW)FGenetic Complementation in Female (BXSB ×

F 1 hybrids among New Zealand Black (NZB), New Zealand White (NZW), and BXSB lupus-prone strains develop accelerated autoimmunity in both sexes regardless of the speciﬁc combination. To identify BXSB susceptibility loci in the absence of the Y chromosome accelerator of autoimmunity ( Yaa ) and to study the genetics of this complementation, genome-wide quantitative trait locus (QTL) mapping was performed on female (BXSB (cid:1) NZW)F 2 mice. Six QTL were identiﬁed on chromosomes 1, 4, 5, 6, 7, and 17. Survival mapped to chromosomes 5 and 17, anti-chromatin Ab to chromosomes 4 and 17, glomerulonephritis to chromosomes 6 and 17, and splenomegaly to chromosomes 1, 7, and 17. QTL on chromosomes 4 and 6 were new and designated as Lxw1 and -2 , respectively. Two non-MHC QTL (chromosomes 1 and 4) were inherited from the BXSB and the rest were NZW-derived, including two similar to previously deﬁned loci. Only two of 11 previously deﬁned non-MHC BXSB QTL using male ( Yaa (cid:2) ) crosses were implicated, suggesting that some male-deﬁned BXSB QTL may require coexpression of the Yaa . Findings from this and other studies indicate that BXSB and NZB backgrounds contribute completely different sets of genes to complement NZW mice. Identiﬁcation of susceptibility genes and complementing genes in several lupus-prone strain combinations will be important for deﬁning the epistatic effects and background inﬂuences on the heterogeneous genetic factors responsible for lupus induction. The Journal of Immunology, 2003, 171: 6442–6447.
Correlated Measurement Errors, Bounds on Parameters, and a Model of Producer Behavior

We examine estimation of a model of producer behavior in the presence of correlated measurement errors in the regressors. Scale economies and price-cost margins are estimated from a set of panel data for manufacturing plants. The paper presents a somewhat new model for estimation of these parameters which is highly flexible but with a simple regression structure. Perhaps the most important contribution of the paper is some new results on deriving parameter bounds for a regression model with errors in variables. In particular, we consider the case where the measurement errors might be correlated. We derive asymptotic standard errors for the parameter bounds. These asymptotic standard errors are compared to bootstrap estimates. Our new results on parameter bounds are applied to the estimation of the model of producer behavior.
Analysis of 10.7- (cid:109) m Brightness Temperatures of a Simulated Thunderstorm with Two-Moment Microphysics

A cloud-resolving model was used in conjunction with a radiative transfer (RT) modeling system to study 10.7- (cid:109) m brightness temperatures computed for a simulated thunderstorm. A two-moment microphysical scheme was used that included seven hydrometeor types: pristine ice, snow, aggregates, graupel, hail, rain, and cloud water. Also, ﬁve different habits were modeled for pristine ice and snow. Hydrometeor optical properties were determined from an extended anomalous diffraction theory approach. Brightness temperatures were computed using a delta-Eddington two-stream model. Results indicate that the enhanced ‘‘V,’’ a feature sometimes seen in satellite infrared observations, may be formed through an interaction between the overshooting dome and the upstream ﬂanking region of high pressure. This idea is contrary to one in which the overshooting dome is viewed as an obstacle to the environmental ﬂow. As expected, the radiative effects of pristine ice particles within the anvil largely determined the brightness temperature ﬁeld. Although brightness temperatures were found to be insensitive to microphysical characteristics of moderate to thick portions of the anvil, a strong relationship did exist with column-integrated pristine ice mass for cloud optical depths below about 5. Precipitation-sized hydrometeors and surface precipitation rate, on the other hand, failed to exhibit any meaningful relationship with the cloud-top brightness temperature. The combined mesoscale model and RT modeling system used in this study may also have utility in satellite product development prior to launch of a satellite and in satellite data assimilation.
University of Birmingham The Hausdorff-Young inequality on Lie groups

We prove several results about the best constants in the Hausdorff–Young inequality for noncommutative groups. In particular, we establish a sharp local central version for compact Lie groups, and extend known results for the Heisenberg group. In addition, we prove a universal lower bound to the best constant for general Lie groups.
Mathematical literacy ability on project based learning model with RME approach assisted by schoology

Mathematical literacy skills need to be improved so that students are able to solve mathematical problems correctly. This study aims to (1) To find out the mathematical literacy abilities of students in the PjBL model with the RME approach assisted by media, Schoology can achieve classical completeness or more; (2) To find out which one is better between the average mathematical literacy abilities in the PjBL model, the RME approach is assisted by Schoology's media in the experimental class and the DL model's Scientific approach in the control class. The population in this study was VII grade students in a school in the city of Semarang. This research is quantitative research. Sampling is done by random sampling technique. The results of the study showed that using the PjBL model of the RME approach assisted by Schoology in achieving classical completeness, and learning the PjBL with the RME approach assisted by the Schoology media in the experimental class had an average mathematical literacy ability compared to DL learning Scientific approaches in the control class.
Immature stages and natural history of Yphthimoides borasta (Nymphalidae: Euptychiina)

: The present paper describes the immature stages and the natural history of Yphthimoides borasta . Eggs are pinkish white and round, with poorly marked hexagonal cells; the first instar is pale brown, turning dark brown with longitudinal zigzag stripes in later instars; the pupae are short, brown, without ornamentation or projections and with short, squared ocular caps. The immature stages are similar to those of other species of the genus Yphthimoides and to other representatives of the “ Megisto clade”. Observed sex ratio in the field is 1:1 and adults fly in the canopy, explaining the rarity of this species in inventories and museum collections in comparison with other species of Yphthimoides . os estágios imaturos de Yphthimoides borasta . Os ovos são rosa claro e esféricos, com diversas células hexagonais pouco marcadas; os primeiros ínstares são marrom-claros, passando a marrom escuro com marcas em zigue-zague longitudinais nos últimos ínstares; as pupas são curtas, marrons e sem ornamentações ou projeções, com as capas oculares curtas. Os estágios imaturos são muito similares àqueles de outras espécies do gênero Yphthimoides e de outros representantes do “clado Megisto ”. A razão sexual é igual a 1:1 e os adultos voam no dossel, o que pode explicar sua raridade em inventários e coleções de museus quando comparado com outras espécies de Yphthimoides.
SURFACE Extracting Black Hole Physics from the Lattice Extracting Black Hole Physics from the Lattice

: We perform lattice simulations of N D0-branes at ﬁnite temperature in the decoupling limit, namely 16 supercharge SU ( N ) Yang-Mills quantum mechanics in the ’t Hooft limit. At low temperature this theory is conjectured to be dual to certain supergravity black holes. We emphasize that the existence of a non-compact moduli space renders the partition function of the quantum mechanics theory divergent, and we perform one loop calculations that demonstrate this explicitly. In consequence we use a scalar mass term to regulate this divergence and argue that the dual black hole thermodynamics may be recovered in the appropriate large N limit as the regulator is removed. We report on simulations for N up to 5 including the Pfaﬃan phase, and N up to 12 in the phase quenched approximation. Interestingly, in the former case, where we may calculate this potentially diﬃcult phase, we ﬁnd that it appears to play little role dynamically over the temperature range tested, which is certainly encouraging for future simulations of this theory.
Case Report Nivolumab-induced thyroid dysfunction

Nivolumab (ONO-4538) is an anti-programmed death-1 specific monoclonal antibody, which has become a standard treatment for metastatic malignant melanoma. Nivolumab induces autoimmune adverse events, defined as immune-related adverse events. Herein, we report a case of nivolumab-induced thyroid dysfunction in the clinical setting. Fourteen patients were treated with nivolumab at our institute, of which three developed thyroid dysfunction, an incidence higher than previously reported in the initial clinical trials. Interestingly, one patient achieved complete remission; suggesting that in some patients, the occurrence of immune-related adverse events, including thyroid dysfunction, might reflect the drug ’ s antitumour efficacy. No patient died or discontinued nivolumab treatment owing to thyroid dysfunction. Although thyroid dysfunction first appeared to be asymptomatic, two of the three patients developed symptoms related to hypothyroidism soon after, requir-ing hormone replacement therapy. Another patient developed hyperthyroidism that was initially asymptomatic; the patient subsequently developed myalgia with fever >39.5°C after two additional courses of nivolumab. Treatment with nivolumab was therefore discontinued, and treatment with prednisolone was initiated. Symptoms resolved within a few days, and thyroid function normalized. Thyroid dysfunction is sometimes difficult to diagnose because its symptoms similar to those of many other diseases. In addition, thyroid-related immune-related adverse events may present with unique symptoms such as myalgia with high fever, abruptly worsening patients ’ quality of life. Consequently, thyroid dysfunction should be considered as a possible immune-related adverse event. Thus, it is important to test for thyroid dysfunction at baseline and before the administration of each nivolumab dose if possible.
Rb-Sr isotope evidence on the age of the Nagssugtoqidian orogeny in West Greenland, with remarks on the use of the term 'Nagssugtoqidian'

According to the original definition, the Nagssugtoqidian orogeny took place after the intrusion of the Kangamiut dykes in West Greenland (Ramberg, 1948). Two of these dykes have been dated recently and gave a Rb-Sr whole-rock isochron age of 1950 ± 60 m.y. * (Kalsbeek et al., 1978). On the basis of petrographic and (isotope-) chemical criteria it was argued that this age dates the intrusion of the dykes and not a much later metamorphism, and this conclusion is supported by other lines of evidence (see Kalsbeek et al., 1978). A lower age limit for the Nagssugtoqidian metamorphism is given by K-Ar biotite ages in the range of 1600-1800 m.y. (e.g. Larsen & Møller, 1968). The post-dyke Nagssugtoqidian metamorphism thus took place between c. 2000 and c. 1800 m.y. , perhaps continuing to c. 1600 m.y. Newer Rb-Sr whole-rock investigations in the Umanak-Upernavik region also indicate regional metamorphism at some time between 2000 and 1750 m.y. Metapelitic supracrustal rocks of the Marmorilik Formation (Umanak district) that overlies the basement with a well-preserved unconformity (Garde & Pulvertaft, 1976), gave an eight-point isochron suggesting an age of 1785 ± 25 m.y. for the metamorphism of the rocks. The Prøven granite-charnockite (Upernavik district) has given an age of 1865 ± 25 m.y. This granite cuts aIready metamorphic supracrustals (correlating with supracrustal rocks in the Umanak region) but has a faint metamorphic fabric itself, and thus probably intruded during the waning stages of the metamorphism. Assuming broad contemporaneity of the metamorphism in the Rinkian complex and the Nagssugtoqidian mobile belt to the south, the age of the main Nagssugtoqidian metamorphism seems thus reasonably well established. The age of the pre-dyke shear zones, now commonly referred to as Nag. 1, is as yet more elusive. Rb-Sr analysis, several years ago, of a number of scattered samples of Nagssugtoqidian gneisses, gave a poor isochron, suggesting an age of 2640 m.y. (2700 m.y. using A 87Rb = 1.39 x IO-H/y). The interpretation of this age, however, is not quite clear. The Nagssugtoqidian gneisses studied, among which there were several samples from shear zones in the Archaean basement, are distinctly richer in Rb than the Archaean gneisses from which they presumably formed, and it is possibly that the 2640 m.y. age dates a Rb metasomatism affecting the rocks during the Nag. 1 shear zone formation (Kalsbeek & Zeck, 1978). If this is so then also the Nagssugtoqidian gneisses that are not obviously affected by Nag. 1 must
Some theoretical aspects of the two-level magnetovariational method

We discuss some theoretical aspects of the two-level magnetovariational method for the determination of the underground electrical structure. The properties of two new apparent resistivity functions, respectively depending on gain and phase of the transfer function of the horizontal magnetic field variations between the Earth's surface and a given depth, are examined for two-layer Earth models. The effects of a finite wavelength of the source field are also investigated. It is shown that the measurement of the attenuation of the magnetic vertical component generated by an inhomogeneous source field can provide further information on the vertical distribution of the Earth's conductivity. In particular, it is shown that the measurement of the transfer function of both vertical and horizontal components between two levels can be used to estimate the average conductivity of the interlying medium.
A COMPARATIVE STUDY ON THE HAEMOCYTES OF THE FIFTH INSTAR LARVAE OF A BIVOLTINE BREED AND MULTIVOLTINE BREED OF THE MULBERRY SILKWORM, BOMBYX

Haemocytes perform various physiological functions in the body of an insect. Total and specific haemocyte populations indicate the immunological status of an insect. The total number of haemocytes (THC) and the different haemocyte count (DHC) vary during the growth and metamorphosis of different breeds of the silkworm. The THC and DHC of a multivoltine breed were compared with that of a bivoltine breed in this work. THC of multivoltine breed ranged from 6.4 x 10 3 / mm 3 on the 1 st day to 10x10 3 /mm 3 on the 5 th day. THC of bivoltine breed ranged from 3.2x 10 3 / mm 3 on the 1 st day to 6.4 x 10 3 /mm 3 on the 5 th day. Only four different types of haemocytes were observed in the haemolymph of both breeds. They were prohaemocyte, granulocytes, spherule cells and oenocytoids. ʽtʼ test values indicate that significant differences were observed between the two breeds in terms of THC and DHC.
A STUDY OF PITUITARY MACROADENOMAS-DIAGNOSIS AND MANAGEMENT IN A TERTIARY CARE HOSPITAL

: INTRODUCTION: Pituitary tumors are one of the common primary brain tumors accounting for 10% to 15% of all primary brain tumors 1 . These tumors have a high incidence between the third and sixth decades of life. The morbidity associated with pituitary macroadenomas may include permanent visual loss, ophthalmoplegia, and other neurological complications. Advances in the medical and surgical management of the tumors and the availability of hormonal replacement therapies have contributed to their successful management. AIM OF THE STUDY: To study the clinicopathological manifestations and management of pituitary macroadenomas. MATERIALS AND METHODS: This is a prospective study, comprising of 25 patients of pituitary macroadenomas studied over a period from 2009 to 2012 in the department of Neurosurgery, Andhra Medical College, King George Hospital, Visakhapatnam. It is a Tertiary Care Hospital. DISCUSSION AND ANALYSIS: Pituitary macroadenomas, particularly prolactinomas respond well to medical therapy. But most of the macroadenomas need surgical intervention for relief of clinical and endocrinological symptoms. CONCLUSION: Pituitary adenomas are benign intracranial tumors which can attain a large size. Presentation usually occurs with visual disturbances, headache and endocrine disturbances. Incidence of these tumors is most common between third and fourth decades of life. Majority of this tumor are nonfunctioning with most of them having suprasellar or parasellar extension at the time of diagnosis. Transcranial intradural approach was an effective method for large tumors with suprasellar and parasellar extensions.