Miracle-dz/UniFAR-FTUs huggingface dataset:
Evaluation of Expression Pattern of Vascular Endothelial Growth Factor (VEGF) and Interleukin-23 (IL-23) Genes in Human Colorectal Tumors

Background: There is a very long interval between the time of tumor initiation and diagnosis of CRCs. So, by early screening by molecular markers, individuals can be diagnosed in a much more convenient time to start the therapies. Among key factors deregulated in advanced CRC, are VEGF (vascular endothelial growth factor) and interleukin-23, which have critical roles in tumor angiogenesis and growth respectively.Objectives: The main purpose of the study was to elucidate the patterns of VEGF-A and IL-23 (IL-23p19) molecular expression in CRC.Material and methods: 47 human colorectal cancer tissues and 47 matched tumor-free margin tissues were gathered during surgery. The mRNA expression levels of VEGF-A and IL-23p19 were examined by real-time quantitative polymers chain reaction (qPCR). Results: The mRNA expression levels of VEGF-A and IL-23p19 were higher in tumor tissues than in the tumor-free margin (control) (p=0.008 and p=0.002, respectively). Though, there was no important association between the mRNA expression levels of VEGF-A and IL-23p19 with clinicopathological features. There was also a positive correlation between these 2 genes expression levels.Conclusion: The analysis of IL23p19 and VEGF-A genes expression could be considered as a biomarker for screening CRC patients and are suggested to be used for diagnosis. Thus, collectively, the high expression level of VEGF-A and IL-23p19 can be considered as a risk factor for CRC carcinogenesis, contributing to high proliferation and invasive properties of the tumor.
Determinants of bottle feeding among 0-24 months children

Background: To study various determinants of bottle feeding like factors related to children, mother and other factors. Methods: cross sectional study done from February 2019 to November 2019. A total 390 children were included in this study. Children who were 0-24 months & anytime bottle fed during this period and who were attending pediatric department of G.G. Govt. hospital & One private hospital, were enrolled. Data collected by interviewer & entered in case record sheet. Results: M:F ratio is 1.56. Bottle feeding seen in all socio-economic classes with highest rate in upper socio-economic class I. History of NICU stay was found in 25.6%. Percentage of preterm, twins & congenital anomaly are 14.4,12.3 & 3.6 respectively. Most mothers are 20-34 age & nonworking. About 30.3% had history of LSCS. About 14.4% have breast problem & 69.7% mothers had belief of “Not enough milk”. Maternal death/non availability, hypothyroidism, chronic illness, smoking & psychosis seen in only 1.5,0.5,2.1,3.6 & 0.5 percentage respectively. 99.5% mothers don’t have proper knowledge of breastfeeding in antenatal period. 31.8% mothers got inputs from nearby circle to start bottle feeding. 28.79% have unsupportive father & 17.48% have unsupportive family.19. 02% have >2 kids. 10.8% does not have proper spacing. 14.4% shows previous h/o bottle feeding. Conclusions: Improper maternal knowledge regarding breast feeding, mothers’ belief of “Not enough milk”, inputs to start bottle from nearby circle, LSCS delivery, Male child, NICU stay, Unsupportive father & >2 kids are most eminent factors. There is a strong need for lactation guidance during antenatal period & breast-feeding counseling to mother, father and close family members.
Public and pharmacist perceptions towards counterfeit medicine in Lebanon using focus groups

Counterfeit medicine is a product that is deliberately and fraudulentlymislabelled with respect to identity or source. The international concern is the risk counterfeits pose for public health. To date, there are no published studies on public and pharmacist perceptions towards counterfeit medicine in Lebanon. Therefore, the aim of the study was to explore participants’ experiences, views and beliefs regarding counterfeit medicine by employing the mixed methods methodology.Methods: The study used four focus groups. The two public focus groups were recruited using the convenience sampling method from two schools in Mount Lebanon. The two pharmacists’ focus groups were recruited by the snowball approach from different pharmacy settings. All participants were above 18 years old.Results: The public and pharmacist focus groups had a total of 24 and 13 participants respectively. Using thematic analysis, themes and subthemes emerged from the discussions, and the common themes between the public and pharmacists were; awareness, trust, corruption and overcoming counterfeit medicine.Conclusions: The findings showed the perceived risk counterfeit medicine pose to individuals and public health. According to focus group participants, the situation is serious and requires more attention from the Ministry of Public Health and Order of Pharmacists. Therefore, the need is to establish strict control on medicine; implement and enforce the law; reactivate the central laboratory; create a counterfeit medicine reporting system, and develop continuous educational programs.
Long-term outcomes in patients (pts) with ipilimumab (ipi)-naive advanced melanoma in the phase 3 KEYNOTE-006 study who completed pembrolizumab (pembro) treatment.

9504Background: Pembro demonstrated superior PFS and OS vs ipi in ipi-naive pts with advanced melanoma in the phase 3 KEYNOTE-006 study (NCT01866319). Here, we present long-term outcomes for all pts and in those pts who completed pembro therapy. Methods: Eligible pts (N = 834) were randomized 1:1:1 to pembro 10 mg/kg Q2W, pembro 10 mg/kg Q3W, or ipi 3 mg/kg Q3W for 4 doses. Treatment was continued for 2 yr (pembro only) or until disease progression, intolerable toxicity, or pt/investigator decision to discontinue. Per protocol, pts could interrupt pembro for ≤12 wk before discontinuation was required. Tumor imaging was performed at wk 12, then every 6 wk up to wk 48 and every 12 wk thereafter. After the prespecified final analysis, response assessments were per immune-related response criteria (irRC) by investigator review. Results: As of the data cutoff (Nov 3, 2016), median follow-up in the total population was 33.9 mo (range, 32.1-37.6). 33-mo OS rates were 50% in the pooled pembro arms (n = 556) and 3.
Haemophilus parainfluenzae as a rare cause of pyogenic liver abscess: A case report and literature review

We report a case of Haemophilus parainfluenzae pyogenic liver abscess in a 53-year-old Filipino female who was admitted with a 3-day history of abdominal pain and fever. Clinical examination showed tenderness in right hypochondrium, and the liver edge was just palpable. Abdominal ultrasound revealed heterogeneous lesion in the left liver lobe, consistent with liver abscess, which was aspirated and the patient received ceftriaxone and metronidazole empirically. Two days after admission, pus culture grew profuse growth of H. parainfluenzae which was sensitive to ampicillin and ceftriaxone, accordingly metronidazole was stopped and ceftriaxone was continued 2 g daily intravenously. The drain was removed on 14th hospital day. Patient made a good recovery and was discharged home on oral cefuroxime for 2 weeks more.
The Effects of Mu and Kappa Opioid Antagonists on Reinstatement of Sugar Seeking

THE EFFECTS OF MU AND KAPPA OPIOID ANTAGONISTS ON REINSTATEMENT OF SUGAR SEEKING Justin Ferdinand Advisor: University of Guelph, 2014 Professor F. Leri Excessive consumption of palatable food is related to death caused by cardiovascular disease, fatty liver disease, and diabetes in humans and animals. Resumption of consuming palatable food following abstinence can be thought of as relapse. Reinstatement of sugar seeking in rats serves as animal model for studying relapse to excessive consumption of palatable foods in humans. Given the known role of mu and kappa receptors in hedonic eating, satiety, stress and food seeking, and food-restriction induced drug seeking, it was predicted that Naltrexone (mu-opioid antagonist; doses: 0.3 mg/kg and 3 mg/kg) and JDTic (kappa-opioid antagonist; doses: 3 mg/kg and 10 mg/kg) drugs should prevent reinstatement of sugar seeking caused by food-restriction stress and by priming. Rats were trained to self-administer sugar in an eight arm radial apparatus where tests of seeking and consumption were also tested. It was found that NTX, but not JDTic, blocked reinstatement caused by food-restriction. While these two antagonists had opposite effects on sucrose self-administration during reacquisition, both attenuated the effects of food restriction on reinstatement induced by the sugar prime. Furthermore JDTic appeared to dose dependently enhance nose poking in food restricted rats during the test of prime-induced reinstatement. These data confirm the critical role of opioid systems in sugar consumption and sugar seeking, further demonstrate the clinical relevance of using mu-opioid antagonists to treat problematic eating and warrant further investigation of a role for kappa opioid receptors in feeding related behaviour.
Exploring Appreciative Advising as an Equity Approach for African American Students: A Grounded Theory Study of Academic Advisors at Predominantly White Institutions (PWIs)

Part of the Academic Advising Commons, Adult and Continuing Education Commons, Adult and Continuing Education Administration Commons, Bilingual, Multilingual, and Multicultural Education Commons, Community College Education Administration Commons, Community College Leadership Commons, Disability and Equity in Education Commons, Educational Leadership Commons, Elementary and Middle and Secondary Education Administration Commons, Higher Education Commons, Higher Education Administration Commons, Other Educational Administration and Supervision Commons, and the Urban Education Commons
Limit Equilibrium Payoffs in Stochastic Games

We study the limit of equilibrium payoffs, as the discount factor goes to one, in non-zero-sum stochastic games. We first show that the set of stationary equilibrium payoffs always converges. We then provide two-player examples in which the whole set of equilibrium payoffs diverges. The construction is robust to perturbations of the payoffs and to the introduction of normal-form correlation.
The Role of the Environment in Sedentary Behavior in Community-Dwelling Older Adults

ABSTRACT To compare amounts of sedentary behavior and physical activity in adults residing in planned group residential settings to those residing in private homes, this study recruited 31 older adults who resided in planned group residential settings (n = 13) and in private homes (n = 18). Daily activities were measured using the SenseWear Armband for 7 days. Estimates of the duration of daily activities performed across sedentary, light, and moderate-to-vigorous intensities were captured. It was found that participants in planned group residential settings were older (age 85.9 ± 3.5 vs. 78.3 ± 7.2; p = 0.001) and spent more time in sedentary behaviors (12.7 ± 1.5 vs. 11.3 ± 1.6; p = 0.02) than participants in private homes. The difference was attenuated slightly after controlling for age and wear time (adjusted difference 1.2 ± 0.6 hours, p = 0.06). Thus, adults residing in planned group residential settings, which provide supportive services, were more sedentary than adults residing in private homes. The environment in which older adults live may contribute to sedentary behavior.
Relationship of Negative Strategies of Emotion Regulation with Anxiety and Depression in the Students of Shiraz University of Medical Sciences, Shiraz, Iran

Background: Diﬀerentinvestigationsindicatedtheroleof cognitiveprocessesinthedevelopmentof anxietyanddepression. Cognitive emotion regulation refers the way in which cognitive processing confront with stressful situations. The current study aimed atpredictingthesymptomsof depressionandanxietythroughcognitiveemotionregulationinthemalestudentsof ShirazUniver-sity of Medical Sciences, Shiraz, Iran. Methods: The current descriptive study was conducted on all the male students of Shiraz University of Medical Sciences studying at the university in 2016. The study sample included 204 subjects selected by the multistage cluster sampling method. Data were collected by the depression anxiety stress scale (DASS) - 21 and the cognitive emotion regulation questionnaire. Data were analyzed with SPSS version 23 using the Pierson correlation and stepwise multiple regression analysis. Results: Theresultsshowedasigniﬁcantpositiverelationshipbetweendepressionandself -blame(r=0.32), depressionandrumi-nation (r = 0.33), depression and catastrophic thinking (r = 0.48), depression and other-blame (r = 0.40), anxiety and self - blame (r = 0.28), anxiety and rumination (r = 0.33), anxiety and catastrophic thinking (r = 0.47), and depression and other - blame (r = 0.45). Also,theresultsshowedthatthelevelof depressionandanxietystudentsarepredictablewithregardtothenegativecognitiveemo-tion regulation. Among the cognitive emotion regulation strategies, catastrophic thinking could predict depression. Also, among the cognitive emotion regulation strategies, catastrophic thinking and other-blame could predict the anxiety. Conclusions: It seems that negative emotions correlate with anxiety and depression in medical students.
The evaluation of different hospital equipment microbial contamination in medical training center Hajar of Shahrekord

Results: The finding frame 137 cultures were showed that125 microbial culture was positive (91%) and 12 microbial cultures was negative (9%). The among microbial culture the highest bacterial contamination is related to bacillus bacteria (32.1%). The among different hospital wards highest bacterial contamination is related to heart, neonate, internal, intensive care unit 1 and 2 and dialysis is (96%) labor (95.5%)-neonate (90.5%) operation room (80%)-the among different hospital instrument highest microbial contamination for .
Serum iron parameters in liver cirrhosis

The liver plays a fundamental role in iron homeostasis. Iron parameters change, especially ferritin, need to be evaluated in patients with liver cirrhosis. Serum ferritin could predict the prognosis of patients with decompensated cirrhosis since it reflects immunemediated and infectious stimuli. Ferritin could express the severity of liver disease and possible subsequent complications. Finally, it might reflect an iron overload condition resulting in significant morbidity and early mortality. 70 patients with decompensated liver cirrhosis divided into three Child-Pugh subgroups. Serum iron parameters include serum iron (SI), total iron binding capacity (TIBC) and ferritin was measured in these groups. From these 70 patients, 30 (42.9%) with HbsAg positive, 26 (37.1%) with anti-HCV positive and 14 (20%) with both HbsAg and anti-HCV positive. Of the 70 patients, 14 (20%) had CTP Class A cirrhosis, 17 (24.3%) had CTP Class B cirrhosis, and 39 (55.7%) had CTP C cirrhosis. The median (range) value of serum iron was 36 (10-345) μg/dl, TIBC was 160 (59-520) μg/dl, Ferritin was 253.5 (8-6078) ng/ml and the transferrin saturation was 22.9 (3.65-216.98) %. We found a significant difference in serum ferritin level with CTP score. Ferritin levels increased as Child-Pugh class progressed (p<0.001).
Conversational implicature comprehension strategies used by English learners in Indonesia

Pratama, Hendi, Fathur Rokhman, and Sri Rejeki Urip. 2019. Conversational implicature comprehension strategies used by English learners in Indonesia. Linguistic Research 36(3), 415-458. Comprehension of conversational implicature is relatively easy for native speakers. However, the same degree of ease does not apply to second language learners. This study aims to uncover the strategies of second language learners despite the difficulties they face. Eighteen respondents are invited to join think-aloud protocols (TAP sessions). During the TAP sessions, respondents are instructed to answer thirty written questions assessing conversational implicature and, at the same time, asked to narrate their thoughts out loud during the session. The responses during these sessions are recorded and transcribed. The data is then codified and analyzed using receptive strategy categorization developed by Vandergrift (1997). The results of the analysis lead to clues on how second language learners, in general, strategize to understand conversational implicature. This study also reveals the difference between strategies used by learners with high implicature scores and those used by learners with low implicature scores. (Universitas Negeri Semarang)
An Analytical Model for the Many-to-One Demand Responsive Transit Systems

The demand-responsive transit (DRT) service is an emerging and flexible transit mode to enhance the mobility of the urban transit system by providing personalized services. Passengers can make advanced appointments through smartphone applications. In this paper, an analytical model is proposed for the many-to-one DRT system. The agency and user costs are approximated by closed-form expressions. The agency cost, which is also the operation cost, is approximated by the continuum approximation technique. A nearest-neighbor routing strategy is applied, whereby the vehicle always collects the nearest passenger waiting in the system. The Vickrey queueing theory is adopted as the basis for approximating each component of the user cost, which is composed of the out-of-vehicle and in-vehicle waiting times and schedule deviations, which also depend on the service quality of the DRT system. The results of the numerical experiment show that (1) the agency and user costs are influenced significantly by the demand density, and (2) the DRT operator cannot further decrease the operating cost by solely deploying larger vehicles.
Parent perspectives on effectiveness of speech language pathologists during home visits for early intervention

Within the fields of counseling and psychology, the client-clinician alliance has been identified as an important factor for therapeutic change (Wampold, 2001). The current study aims to extend this finding into the realm of home-based early intervention services. Because these services are conducted in the home, families interact frequently with speech language pathologists (SLPs). Therefore, characterizing the relationship between parent and clinician has important implications for positive perceptions of therapy. Thematic analysis of surveys and interviews completed by two parents revealed their perceptions of how effective their SLPs were during the early intervention process. They identified two specific components that led to positive experiences: the logistics of therapy and the parent-clinician alliance. Similar to the findings in other fields, the relationship between clients and clinicians play an important role in the homebased early intervention process. SLPs need to develop interpersonal skills that facilitate a strong client-clinician relationship. Specifically, agreeing with parents on the role of therapy and teaching parents strategies to use with their children were important themes in our study. Likewise, open lines of communication, in both written and oral modalities, as well as clinician comfort with parents and children were highly valued factors for a clinician to possess. Teaching SLPs how to develop positive client-clinician relationships will lead to positive early intervention experiences.
Clinical Significance of LipoproteinSize and Risk for CoronaryAtherosclerosis

plasma lipoprotein metabolism. The LDL size is influencedby genetic,endocrine,and environmental factors. Withinthe high-densitylipoprotein(HOL) familythe decrease of larger HDL2 particles is associated with coronary heart disease. HDLs can also be separatedaccording to their apoprotein composition into particles containinglipoprotein(Lp)A-l only and particlescontaining LpA-l and LpA-ll. Most studieshave shownthat the concentration of LpA-l-only particles decreases in coronary heart disease. HDL5 are remodeled in the circulation and this remodelingcontinuesin vitroafter the bloodis taken.Thereforeadequatepreservation of bloodsamples is necessary.
Palliative care awareness among health care professionals in Nigeria.

e20548 Background: There has been a marked increase in the global incidence of cancer and HIV. In low to middle income countries like Nigeria, 70% of patients present late. With limited resources for treatment, palliative care is critical in improving the quality of life of these patients. In Nigeria, the awareness of palliative care is low. This study aims to assess the awareness of palliative care among some health care professionals in Lagos, Nigeria. Methods: A cross sectional questionnaire was distributed to 100 participants at a breast cancer workshop at a university teaching hospital in the major urban center in Nigeria. It sought information about the socio-demographic profile of the respondents as well as their palliative care knowledge, acceptance and challenges in their practices. Information obtained was entered and analyzed using SPSS version 16. Results: 71% of the questionnaires were completed. 52% of participants were male. The median age of participants was 40 years. 46% were general prac.
Qualitative Analysis of Bacterial Aerosols Generated during Ultrasonic Dental Scaling

Aims: To compare the efficacy of two mouth rinses (0.2% Chlorhexidine and 5% green tea mouth rinse) in reducing the bacterial load (CFUs) in aerosol samples collected during ultrasonic dental scaling and to do the qualitative analysis of bacterial isolates. Study Design: Quasi experimental study. Place and Duration of Study: Department of Periodontics (Ziauddin college of Dentistry), Ziauddin University, Karachi, between January 2019 to August 2019. Methodology: This study comprised of seventy patients (43 males and 27 females) within the age group of 20 to 65 years having gingival and plaque score between 1 and 3 and mean probing depth less than 5 mm. All study subjects were divided into 2 equal groups (group 1 and group 2). A split mouth design was used for ultrasonic scaling (oral prophylaxis). Control side was scaled without pre rinsing while the test side was scaled after pre procedural mouth rinsing. Group 1 study Original Research Article Anjum et al.; JAMMR, 31(11): 1-12, 2019; Article no.JAMMR. 53954 2 subjects were instructed to rinse with 10 ml 0.2% Chlorhexidine mouth rinse for one minute and Group 2 rinsed with 10 ml 5% green tea mouth rinse for a minute. Fresh blood agar plates were used for air sampling, which were then transported to Microbiology laboratory (JPMC) for aerobic culturing and microbiological examination. Results: Greater percentage of Gram positive bacteria were found in aerosol samples generated during ultrasonic scaling. Gram positive cocci (Staph epidermidis and Micrococci species) were in abundance and very few gram negative bacteria were detected. Conclusion: Dental health care providers and patients can easily acquire infections because of contaminated aerosols and splatters and so all infection control measures should be taken to minimize these risks. Pre procedural mouth rinsing with effective mouthwashes should be done before dental procedures as it is easiest and much economical way of reducing cross infection.