Miracle-dz/UniFAR-FTUs huggingface dataset:
A trans agent of social change in incarceration: A psychobiographical study of Natasha Keating

Abstract Objectives This psychobiography focuses on the advocacy work of Natasha Keating, a trans woman incarcerated in two male prisons in Australia between 2000 and 2007. Incarcerated trans women are a vulnerable group who experience high levels of victimization and discrimination. However, Natasha advocated for her rights while incarcerated and this advocacy contributed to substantial changes in the carceral system. This psychobiography uses psychological understandings of resilience as well as the Transgender Resilience Intervention Model (TRIM) to investigate the factors that enabled this advocacy. Method Data consisted of an archive of letters written by Natasha and interviews with individuals who knew her well. This psychobiography was guided by du Plessis' (2017) 12‐step approach and included the identification of psychological saliencies and the construction of a Multilayered Chronological Chart. Results Natasha's life is presented in four chapters, with each chapter including a discussion of resilience based on the TRIM. Conclusions The TRIM suggests that during incarceration, Natasha was able to access more group‐level resilience factors than at any other time in her life. This, combined with individual resilience factors, enabled her advocacy. This finding has implications for advocacy in general as it highlights the importance of both individual‐ and group‐level factors in enabling individuals to effectively advocate for change in their environments.
Ripple Effects of Abusive Supervision

Abusive supervision (AS) is relentless in damaging employees’ personal and professional life. This study examines the underlying mechanism through which AS damages employees’ job and life satisfaction and, most importantly, the boundary conditions that help attenuate the cascading effects of AS. Using a sample of 187 employees from a large public sector organization, this study found that job tension transmits the antagonistic effects of AS to employees’ job and life satisfaction. However, these effects were low for employees who were high rather than low in the personality trait of resilience. The study contributes to the AS literature by explicating job tension as one possible underlying mechanism and resilience as a personality trait that helps diminish the deleterious effects of AS on employees’ job tension and wellbeing. Theoretical contributions and practical implications are discussed.
Improving the efficiency of remanufacture through enhanced pre-processing inspection – a comprehensive study of over 2000 engines at Caterpillar remanufacturing, U.K.

Abstract Remanufacturing returns used product to an ‘as-new’ condition and is a key strategy in environmentally conscious manufacturing and waste management. However, strategies to improve the efficiency of the process are hampered by a lack of remanufacturing-specific industrial research. This paper presents the results of quantitative research, conducted in an industrial remanufacturing facility, to establish the relationship between pre-processing inspection levels and the subsequent remanufacturing process time for returned used products (known as cores). It concludes that for cores having either complex geometry (such as internal ports), a large number of sub-components or that are constructed from, or comprising of, multiple materials the remanufacturing process is shortened by increased inspection prior to processing. However, these benefits are currently limited by the amount of information that can be gained from the inspection methods used. The authors describes the practical use of these results in both a decision-making methodology for inspection and a cost assessment tool.
Current-Collapse-Free and Fast Reverse Recovery Performance in Vertical GaN-on-GaN Schottky Barrier Diode

The recent emergence of free-standing GaN substrate has enabled the development of vertical GaN-on-GaN power devices. This letter presents the dynamic <sc>on</sc>-resistance (<inline-formula><tex-math notation="LaTeX">$R_{\text{ON}}$</tex-math></inline-formula>) and reverse recovery performance of a novel vertical GaN-on-GaN Schottky barrier diode (SBD) characterized by a double pulse tester. The vertical GaN-on-GaN SBD exhibits fast reverse recovery with a low <inline-formula><tex-math notation="LaTeX">$R_{\text{ON}}$</tex-math></inline-formula>·<inline-formula><tex-math notation="LaTeX">$Q_{\rm rr}$</tex-math></inline-formula> figure-of-merit. For the first time, the current-collapse-free performance (i.e., no dynamic <inline-formula><tex-math notation="LaTeX">$R_{\text{ON}}$</tex-math></inline-formula> degradation) has been experimentally verified in a vertical GaN power rectifier under different switching conditions including: <sc>off</sc>-state stress bias up to 500 V, <sc>off</sc>-state stress time within 10<sup>−6</sup>–10<sup>2</sup> s, high temperature up to 150 °C, and different load current levels.
Post‐neoadjuvant assessment of tumour budding according to ITBCC subgroups delivers stage‐ and regression‐grade independent prognostic information in intestinal‐type gastric adenocarcinoma

Tumour budding (TB) has been associated with adverse clinicopathological factors and poor survival in a plethora of therapy‐naïve carcinoma entities including gastric adenocarcinoma (GC). As conventional histopathological grading is usually omitted in the post‐neoadjuvant setting of GC, our study aimed to investigate the prognostic impact of TB in GCs resected after neoadjuvant therapy. We evaluated TB according to the criteria from the International Tumour Budding Consensus Conference (ITBCC) in 167 post‐neoadjuvant resections of intestinal‐type GC and correlated the results with overall survival (OS) and clinicopathological parameters. GCs were categorised into Bd1 (0–4 buds, low TB), Bd2 (5–9 buds, intermediate TB), and Bd3 (≥10 buds, high TB). Carcinomas with intermediate and high TB were significantly enriched in higher ypTNM stages and strongly associated with reduced 5‐year OS in univariable analyses (p < 0.001). In multivariable analyses including sex, age, resection status, UICC stage, and tumour regression grading, TB remained a stage‐independent predictor of survival (p < 0.001, hazard ratio Bd2: 2.60, Bd3: 4.74). The assessment of TB according to the ITBCC criteria provides valuable prognostic information in the post‐neoadjuvant setting of intestinal‐type GC and may be a considerable substitute for the conventional grading system in GCs after neoadjuvant therapy.
An EÆcient Boosting Algorithm for Combining Preferences

The problem of combining preferences arises in several applications, such as combining the results of di erent search engines. This work describes an eÆcient algorithm for combining multiple preferences. We rst give a formal framework for the problem. We then describe and analyze a new boosting algorithm for combining preferences called RankBoost. We also describe an eÆcient implementation of the algorithm for certain natural cases. We discuss two experiments we carried out to assess the performance of RankBoost. In the rst experiment, we used the algorithm to combine di erent WWW search strategies, each of which is a query expansion for a given domain. For this task, we compare the performance of RankBoost to the individual search strategies. The second experiment is a collaborativeltering task for making movie recommendations. Here, we present results comparing RankBoost to nearest-neighbor and regression algorithms. Thesis Supervisor: David R. Karger Title: Associate Professor
Eccentric contraction‐dominant exercise leads to molecular biological changes in enthesis and enthesopathy‐like morphological changes

Entheses, which are tendon‐to‐bone attachment sites in the musculoskeletal system, play important roles in optimizing the mechanical stress and force transmitted from the muscle to the bone. Sports‐related enthesopathy shows pathological features, including hyperplasia of the fibrocartilage (FC) region in the enthesis. The amount of exercise and type of muscle contraction during movement is involved in the pathogenesis of sports‐related enthesopathy; however, the details of this condition are unclear. Here we examined the molecular pathways involved in the morphological changes of the muscle–tendon–enthesis complex and enthesis FC region in the supraspinatus muscle enthesis of mice under different exercise conditions. Following intervention, morphological changes in the muscle–tendon–enthesis complex were initiated in the eccentric contraction‐dominant exercise group at 2 weeks, with activation of the transforming growth factor‐β (TGFβ) superfamily pathway predicted by proteome and ingenuity pathway analyses. Histological and molecular biological analyses confirmed the activation of the TGFβ/bone morphogenetic protein (BMP)‐Smad pathway. The concentric contraction‐dominant exercise group showed no change in the morphology of the muscle–tendon–enthesis complex or activation of the TGFβ/BMP‐Smad pathway, despite overuse exercise. Statement of Clinical Significance: These results suggest that eccentric contraction‐dominant exercise induces sports‐related enthesopathy‐like morphological changes in the early stages as well as molecular biological changes, mainly in the transforming growth factor‐β superfamily pathway in enthesis.
Integration of supply chain management and quality management within a quality focused organizational framework

A paucity of research has explored the integration of supply chain management (SCM) and quality management (QM) within an overall organizational context. The investigation of integrating SCM and QM within an organizational framework has the potential to foster theory development of SCM and QM and to strengthen SCM and QM practice. The Baldrige Award promotes organization performance excellence and the associated framework has evolved into a notable quality focused organizational framework. Prior studies have focused on validating the effectiveness of the Baldrige framework. In this research, we integrate SCM and QM within the context of a quality focused organizational framework by proposing a modified version of the Baldrige framework and validate the proposed framework. We use cross-sectional survey data to test the hypothesized research model through partial least squares – structural equation modeling. The results support the effectiveness of the proposed framework. The research shows the importance of SCM as a major organizational construct with a significant positive direct influence on organizational results. The research also shows that SCM is a mediator for leadership and measurement, analysis and knowledge management that influence organizational results. This work discusses theoretical and managerial implications as well as implications for future research.
Differential impact of glycemic control and comorbid conditions on the neurophysiology underlying task switching in older adults with type 2 diabetes

Type 2 diabetes is known to negatively affect higher order cognition and the brain, but the underlying mechanisms are not fully understood. In particular, glycemic control and common comorbidities are both thought to contribute to alterations in cortical neurophysiology in type 2 diabetes, but their specific impact remains unknown. The current study probed the dynamics underlying cognitive control in older participants with type 2 diabetes, with and without additional comorbid conditions (i.e., cardiovascular disease, nephropathy, peripheral neuropathy, retinopathy), using a task switching paradigm and a dynamic functional brain mapping method based on magnetoencephalography (MEG). We hypothesized that neural dynamics would be differentially impacted by the level of glycemic control (i.e., diabetes itself) and the burden of additional comorbid conditions. Supporting this hypothesis, our findings indicated separable, but widespread alterations across frontal, parietal, temporal and cerebellum regions in neural task-switch costs in type 2 diabetes that were differentially attributable to glycemic control and the presence of comorbid conditions. These effects were spatially non-overlapping and the effects were not statistically related to one another. Further, several of the effects that were related to the presence of comorbidities were associated with behavioral performance, indicating progressive deficits in brain function with extended disease. These findings provide insight on the underlying neuropathology and may inform future treatment plans to curtail the neural impact of type 2 diabetes.
Driving Forces of Energy-Related CO2 Emissions Based on Expanded IPAT Decomposition Analysis: Evidence from ASEAN and Four Selected Countries

ASEAN is a dynamic and diverse region which has experienced rapid urbanization and population growth. Their energy demand grew by 60% in the last 15 years. In 2013, about 3.6% of global greenhouse-gas emissions was emitted from this region and the share is expected to rise substantially. Hence, a better understanding of driving forces of the changes in CO2 emissions is important to tackle global climate change and develop appropriate policies. Using IPAT combined with variance analysis, this study aims to identify the main driving factors of CO2 emissions for ASEAN and four selected countries (Indonesia, Malaysia, Philippines and Thailand) during 1971–2013. The results show that population growth and economic growth were the main driving factors for increasing CO2 emissions for most of the countries. Fossil fuels play an important role in increasing CO2 emissions, however the growth in emissions was compensated by improved energy efficiency and carbon intensity of fossil energy. The results imply that to decouple energy use from high levels of emissions is important. Proper energy management through fuel substitution and decreasing emission intensity through technological upgrades have considerable potential to cut emissions.
Stress and Susceptibility: A Systematic Review of Prenatal Epigenetic Risks for Developing Post-Traumatic Stress Disorder

This review aims to systematically assess the current literature about prenatal epigenetic markers that lead to post-traumatic stress disorder susceptibility across the lifespan. Studies included in this review met several research criteria: Studies included (1) participants with a PTSD diagnosis according to the DSM-5, (2) prenatal epigenetic marker data that could be analyzed, and (3) explicit references to postnatal PTSD susceptibility. Our study sample fit within a timeframe of 2002 (the earliest recorded studies of prenatal susceptibility to post-traumatic stress disorder in the databases used) and February 2021 when the literature search for this review was terminated. Studies for this review were collated from PubMed, MEDLINE, Science Direct, and Boston College School of Social Work Library databases. A systematic search was conducted in these databases using basic keyword terms, such as “PSTD resilience” and “PTSD vulnerability,” and then adding clarifying terms to refine specific searches, such as “epigenetics,” “genetics,” “epigenetic markers,” “haplotypes,” and “mRNA methylation. ” Based on these criteria and research methods, 33 studies remained for inclusion in the review sample. This review suggests that BDNF Val66-Met, a polymorphism of FKBP5, and an altered messenger ribonucleic acid methylation marker in NR3C1 present most often in cases of PTSD. These epigenetic markers might be implicated in central neurological processes related to post-traumatic stress disorder symptomatology.
Cutaneous manifestations following COVID‐19 vaccination: A report of 25 cases

Various adverse effects particularly cutaneous manifestations associated with different COVID‐19 vaccines have been observed in practice. The aim of our study was to evaluate all patients who presented to our tertiary center with skin manifestations following COVID‐19 vaccines injection from September to December 2021. All patients with skin manifestation within 30 days or less following COVID‐19 vaccination were enrolled in our case‐series. All cases included in our study were diagnosed based on clinical and/or histopathological evaluation and all other possible differential diagnoses were ruled out. Twenty‐five individuals including 16 (64%) males and 9 (36%) females with the mean age of 47 ± 17.62 years (range 18–91) were enrolled in our study. Twenty‐two (88%) patients developed lesions after Sinopharm vaccine injection and 3 (12%) cases manifested lesions after the AstraZeneca vaccine. Six (24%) patients developed new‐onset lichen planus (LP) and 1 (4%) patient manifested LP flare‐up. Two (8%) individuals developed psoriasis and 1 (4%) case showed psoriasis exacerbation. One (4%) patient developed new‐onset pemphigus vulgaris (PV) and 1 (4%) case experienced a flare of PV lesions. One (4%) patient manifested pityriasis lichenoides et varioliformis acuta (PLEVA) flare‐up. Other new‐onset cases were as follows: toxic epidermal necrolysis (TEN) (n = 1, 4%), bullous pemphigoid (BP) (n = 2, 8%), alopecia areata (AA) (n = 2, 8%), pytriasis rosea (n = 1, 4%), herpes zoster (n = 1, 4%), cutaneous small vessel vasculitis (n = 1, 4%), erythema multiform (EM) and urticaria (n = 3, 12%), and morphea (n = 1, 4%). Physicians should be aware of the possible side effects especially cutaneous manifestations associated with COVID‐19 vaccines.
Single‐cell RNA‐seq dissecting heterogeneity of tumor cells and comprehensive dynamics in tumor microenvironment during lymph nodes metastasis in gastric cancer

Lymph node metastasis is the common metastasis route of gastric cancer. However, until now, heterogeneities of tumor cells and tumor microenvironment in primary tumors (PT) and metastatic lymph nodes (MLN) of gastric cancer (GC) remains uncharacterized. In our study, single cell RNA sequencing was performed on tissues from PT and MLN of gastric cancer. Trajectory analysis and function enrichment analyses were conducted to decode the underlying mechanisms contributing to LN metastasis of gastric cancer. Heterogeneous composition of immune cells and distinct intercellular interactions in PT and MLN were analyzed. Based on the generated single cell transcriptome profiles, dynamics of gene expressions in cancer cells between PT and MLN were characterized. Moreover, we reconstructed the developmental trajectory of GC cells' metastasis to LN and identified two subtypes of GC cells with distinct potentials of having malignant biological behaviors. We characterized the repression of neutrophil polarization associated genes, like LCN2, which would contribute to LN metastasis, and histochemistry experiments validated our findings. Additionally, heterogeneity in neutrophils, rather than macrophages, was characterized. Immune checkpoint associated interaction of SPP1 was found active in MLN. In conclusion, we decode the dynamics of tumor cells during LN metastasis in GC and to identify a subtype of GC cells with potentials of LN metastasis. Our data indicated that the disordering the neutrophils polarization and maturation and the activation of immune checkpoint SPP1 might contribute to LN metastasis in GC, providing a novel insight on the mechanism and potential therapeutic targets of LN metastasis in GC.
Muscle activity with 0.5 T upright MRI—DESS to measure T2 in biceps and triceps

The purpose of this study was to determine if muscle activity of the biceps followed by isometric flexion changes T2 measured in the biceps. It is hypothesized that an increase in T2 will be observed in the biceps but not in the triceps after flexion exercise. Ten healthy volunteers were imaged with a one‐channel neck coil while seated in a 0.5 T upright open magnetic resonance imaging (MRI) scanner using a three‐dimensional double echo steady‐state (DESS) sequence. Volunteers were imaged while relaxing their arm for 10, 20, and 30 min during an isometric biceps flexion immediately following performance of biceps curls to exhaustion, and again after relaxing for 10 and 20 min. Voxel‐wise T2 was calculated by fitting to a DESS signal equation in regions segmented at muscle centers to determine mean T2. During isometric biceps flexion immediately following biceps curls, mean T2 increased (average 33%, p < 0.05) in the biceps but not in the triceps. By 20 min after curls, mean T2 decreased (p < 0.05), and was near preactivity values. In contrast, there was no change in triceps T2 across any activity or postactivity time points. Intra‐rater repeatability was excellent (ICC: 0.90–0.97). This study demonstrated that measuring T2 in an active muscle is feasible using a DESS sequence in an upright open MRI scanner. This could enable the study of muscle function while the muscle is working and weight‐bearing, rather than of the “fatigue” of the muscles after activity. In comparison to electromyography, MRI also enables the study of deep muscles and allows simultaneous assessment of activity and function.
Active kisspeptin DNA vaccines oral immunization disrupt mRNA hormone receptors expression in ram lambs

Abstract To evaluate the efficacy of oral immunization with active kisspeptin DNA vaccine on the expression of hormone receptor mRNA. For this study, ten 56-day-old Hu breed ram lambs were randomly assigned to the treatment and control groups (n = 5). Treatment Experimental group received C500/pKS-asd and the control group received C500/pVAX-asd (aspartate-β semialdehyde dehydrogenase orally on days 0, 28, and 56, and blood samples were taken at each immunization interval (14-day) and tissues samples were collected at the end of the experimental period (day 98). The collected samples were stored in the refrigerator at −20 °C and liquid nitrogen, respectively, for laboratory examination. Total RNA was extracted from samples using TRIzol reagent and quantitative real-time polymerase chain reaction (QPCR) was used to quantify the levels of KISS1, G protein-coupled receptor-54 (Kiss1r), and gonadotrophin-releasing hormone (GnRH) mRNA in the hypothalamus. Levels of luteinizing hormone receptor (LHR) and luteinizing hormone beta (LHβ) mRNA, and follicle-stimulating hormone receptor (FSHR) and follicle-stimulating hormone beta (FSHβ) mRNA in the testes and pituitary were analyzed, respectively. Further, gonadotropin-releasing hormone receptor (GnRHR) mRNA expression level in the pituitary was measured. Moreover, the Kiss1r concentration level in the blood was measured using an indirect ELISA. The concentration of Kiss1r in the blood was lower in the treatment group than in the control group (p < 0.05). The levels of testicular FSHR and LHR mRNA were significantly lower in the treatment group (p < 0.05) when compared to the control group. Furthermore, the treatment group's levels of hypothalamic KISS1, Kiss1r, and GnRH mRNA were significantly lower (p < 0.05) than the controls. LH, FSH, and GnRHR mRNA expression in the pituitary were also significantly lower in the treatment group (p < 0.01 and p < 0.05, respectively). These findings imply that oral immunization with active kisspeptin DNA vaccine suppresses hormone receptor mRNA expression in the ram lambs.