Miracle-dz/UniFAR-FTUs huggingface dataset:
Genotype-by-Environment interactions in Maize hybrids using GGE-biplot and AMMI model

Evaluation of the productivity and performance of maize hybrid genotypes in variable environments is a basic demand for releasing varieties. The purpose of this research was to assess the yield, performance, and stability of maize hybrids and to identify suitable environments for maize production in Bangladesh. The maize hybrid Sunshine produced the highest yield (11.24 t ha to 12.85 t ha) followed by Kaveri 60 (7.04 t ha 1 to 12.72 t ha). Genotype ×environment interaction effects have influential effects on the yield of maize hybrids. The sums of squares of GGE were found as 43.96% and 24.2%, respectively, for the principal component 1 (PC1) and principal component 2 (PC2), respectively. In the biplot polygon view, there were six rays that divided the biplot into six sectors and the six environmental locations were accommodated within four sectors. Jessore was determined as the typical test environment for the country followed by Bhurrirhut and Jamalpur. Ideal testing sites would provide information to identify the superior maize hybrids to minimize the expenses of the country. Considering the yield potentiality and stability, Sunshine, 9MS/S5-1×BIL-114 and, 9MS/S7-9×BIL-114 were found as the most stable and high yield producing hybrids across the six environmental conditions. Therefore, these three genotypes were identified as the best hybrids over the locations of Bangladesh. Keywords— AMMI Model, evaluation, GGE-biplot,
Spider Diversity in Some Common Oilseed Crops in Central Punjab, Pakistan

Three commonly cultivated oilseed crops viz., soybean, sunflower and Indian mustard were sampled to compare density and diversity of spider at different developmental stages. This study was conducted at Ayub Agriculture Research Institute, Faisalabad, Pakistan. A total of 1210 spider individuals, 68 species and 5 families were sampled throughout the study period. The families showed different levels of association with the crops, like Lycosidae and Clubionidae were found commonly spread and highly abundant, whereas Philodromidae was only restricted to sunflower and locally rare. The Evippa sohani, Pardosa fletcheri, Evippa shivajii and Pardosa oakleyi were recorded most dominant and commonly spread spider species. Indian mustard constituted highest diversity of spider species followed by soybean and sunflower. Spider species diversity on the Indian mustard was significantly different from the sunflower. These predator species can play a major role to suppress devastating agricultural pests of oilseed crops, thereby enhance the crop yield.
Cell Cycle-dependent Tumor Necrosis Factor Apoptosis1

To determine if tumor necrosis factor (TNF)-mediated apoptosis affects cells at defined stages of the cell cycle, WEHM64/2F (WEHI) cells were synchronized at G,,-G, after 3-day cultures in medium containing KI'Ml 1640 and 0.5% FCS (RPMI-0.5% FCS). The arrested WEHI cells (60-75% in G0-G,) showed increased sensitivity to TNF killing, measured as 48-h 3-(5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide as says, and 15-h apoptosis by propidium iodide staining and flow cytometry analysis. The TNF killing kinetics of G0-G,-arrested cells was similar to controls, and TNF did not accelerate or retard cell cycle progression of the arrested cells after feeding with fresh RPMI-0.5% FCS. However, TNF inhibited WEHI DNA synthesis as early as l h after treatment, and inhibition was proportionate to sensitivity to TNF-induced apoptosis. WEHI cells treated with TNF showed a higher percentage of cells in S phase with concomitant decrease in G(I-G, and G2-M. When cultured for 3-18 h in fresh RPMI-0.5% FCS to allow progression of the G0-G,arrested cells toward the G,-S boundary, WEHI cells became more sen sitive to TNF killing, especially at the 3-9-h time points. Moreover, TNF did not degrade [l25I]5-iodo-2'-deoxyuridine-labeled WEHI DNA if the labeled cells were precultured for 9 h in fresh RPMI-0.5% FCS to allow them to pass S phase before the addition of TNF. These results show that TNF-induced apoptosis of WEHI cells is connected to cell cycle events; WEHI targets receive the TNF cytotoxic signal mainly at the G,-S bound ary and begin to die by apoptosis as they exit from S phase.
Liver fatty acidâ•’binding protein is required for high rates of hepatic fatty acid oxidation but not for the action of PPARâ•’Î± in fasting mice

Liver fatty acid binding protein (L-FABP) has been proposed to limit the availability of longchain fatty acids (LCFA) for oxidation and for peroxisome proliferator-activated receptor α (PPAR-α), a fatty acid binding transcription factor that determines the capacity of hepatic fatty acid oxidation. Here, we used L-FABP null mice to test this hypothesis. Under fasting conditions, this mutation reduced β-hydroxybutyrate (BHB) plasma levels as well as BHB release and palmitic acid oxidation by isolated hepatocytes. However, the capacity for ketogenesis was not reduced: BHB plasma levels were restored by octanoate injection; BHB production and palmitic acid oxidation were normal in liver homogenates; and hepatic expression of key PPAR-α target (MCAD, mitochondrial HMG CoA synthase, ACO, CYP4A3) and other (CPT1, LCAD) genes of mitochondrial and extramitochondrial LCFA oxidation and ketogenesis remained at wild-type levels. During standard diet, mitochondrial HMG CoA synthase mRNA was selectively reduced in L-FABP null liver. These results suggest that under fasting conditions, hepatic L-FABP contributes to hepatic LCFA oxidation and ketogenesis by a nontranscriptional mechanism, whereas L-FABP can activate ketogenic gene expression in fed mice. Thus, the mechanisms whereby L-FABP affects fatty acid oxidation may vary with physiological condition.
Formal Versus Informal Training & Tacit Versus Explicit Knowledge Sharing: What Matters More for the Entrepreneurially Oriented Firms?

The beneficial outcome of a firm‟s entrepreneurial orientation (E.O) has been widely researched, but literature and empirical studies about factors that stimulate E.O remain scarce. Previous research has showed that employee training is a crucial mechanism to foster E.O others has exhibited that a higher level of knowledge sharing is related to a stronger E.O. Although, previous researches do not distinguish neither between different type of training, with the most important distinction being between formal and informal nor between different form of knowledge sharing, with the very popular being between tacit and explicit. In view of the difference for each pair contrasts of one over the other, they are widely considered to have different impact on the E.O‟s dimensions namely innovativeness, proactiveness, and risk-taking in SMEs. Our research model is tested with survey data collected from 186 Tunisian small and medium-sized textile & clothing firms. Findings reveal that the level of each dimension of E.OInnovativeness, proactiveness and risk taking differs based on the form of knowledge sharing either tacit or explicit and the type of training either formal or informal.
IL-4 Suppressing c-Maf Transactivation of Deviation in Nonobese Diabetic Mice by SUMO Conjugation Contributes to Immune

It is not clear why the development of protective Th2 cells is poor in type 1 diabetes (T1D). c-Maf transactivates the IL-4 gene promoting Th2 cell development; therefore, abnormalities in c-Maf may contribute to reduced IL-4 production by CD4 cells from nonobese diabetic (NOD) mice. In this study we demonstrate that despite normal expression, c-Maf binds poorly to the IL-4 promoter ( IL-4 p) in NOD CD4 cells. Immunoblotting demonstrates that c-Maf can be modiﬁed at lysine 33 by SUMO-1 (small ubiquitin-like modiﬁer 1). Sumoylation is facilitated by direct interaction with the E2-conjugating enzyme Ubc9 and increases following T cell stimulation. In transfected cells, sumoylation decreases c-Maf transactivation of IL-4 p-driven luciferase reporter activity, reduces c-Maf binding to the IL-4 p in chromatin immunoprecipitation assays, and enhances c-Maf localization into promyelocytic leukemia nuclear bodies. Sumoylation of c-Maf is increased in NOD CD4 cells as compared with CD4 cells from diabetes-resistant B10.D2 mice, suggesting that increased c-Maf sumoylation contributes to immune deviation in T1D by reducing c-Maf access to and transactivation of the IL-4 gene. The Journal of Immunology, 2009, 183: 1110–1119. any studies point to a correlation between the development of type 1 diabetes (T1D) 3 and decreased Th2 responses (1–4). Poor IL-4 production may to the disease process by limiting protective Th2 responses restricting the activation of nonpathogenic T cells and reducing B7.2 expression on dendritic cells that would curb islet-speciﬁc IgG control Ab, indicating that the 72-kDa band is speciﬁc for c-Maf. Together, these results suggest that c-Maf is sumoylated following stimulation of CD4 cells.
AENDO May 41/5

JEAN-CLAUDE PAINSON,1 JOHANNES D. VELDHUIS,2 AND GLORIA S. TANNENBAUM1 1Departments of Pediatrics and of Neurology and Neurosurgery, McGill University, and the Neuropeptide Physiology Laboratory, McGill University-Montreal Children’s Hospital Research Institute, Montreal, Quebec H3H 1P3, Canada; and 2Department of Internal Medicine, University of Virginia Health Sciences Center and the National Science Foundation Center for Biological Timing, Charlottesville, Virginia 22908
The Review of Regional Studies

: Employing data from Italian manufacturing firms, this paper attempts to check the existence of geographic and industry distance effects on the investment in information and communication technology (ICT). Geographic distance is defined by the Euclidean distance between each possible pair of locations (municipalities) according to their geographical coordinates. Industry proximity is measured by the firms’ industry distance according to the trade intensity between sectors. The model specified here refers to the combined spatial autoregressive model with autoregressive disturbances (SARAR), which are modelled simultaneously. The results show that both geographical and industry proximity have positive effects on the amount of ICT investment by firms. Furthermore, an econometric analysis shows that productivity, R&D activity, subsidies, reorganization, and labor composition are jointly correlated to ICT investment.
Disruption of the 3 663-687 disulfide bridge confers constitutive activity to 3 integrins

The platelet fibrinogen receptor, integrin IIb 3, is a noncovalent heterodimer of glycoproteins IIb and IIIa. This work was aimed at elucidating the role played by the carboxy-terminal extracellular, transmembrane, and cytoplasmic regions of the glycoprotein 3 in the formation of functional complexes with subunits. Progressive carboxy-terminal deletions of 3 revealed that surface exposure of IIb 3 or v 3 could not occur in the absence of the transmembrane domain of 3. In contrast, internal deletions 616 to 690 of the carboxy-terminal regions of the 3 ectodomain led to surface exposure of constitutive active receptors in CHO cells, as indicated by the enhanced rate of cell adhesion to immobilized ligands and spontaneous binding to soluble fibrinogen or activation-dependent antibody PAC-1. The functional analysis of cysteine mutations within the 616 to 690 region of 3 or chimeric 37 subunits revealed that disruption of the C663-C687 disulfide bridge endows constitutive activity to the IIb 3 receptor. It is concluded that the carboxy-terminal tail of the 3 ectodomain, so-called tail domain ( TD), is not essential for cell surface expression of 3 receptors. However, a basal, nonactivated, low ligand-affinity state of the 3 integrins demands a normal conformation of this domain. (Blood. 2003;102: 2491-2497)
Indentation-induced deformation localisation in Zr-Cu-based metallic glass

It has been well documented that the plastic deformation of bulk metallic glasses is localised in thin shear bands. In order to comprehensively understand deformation mechanisms of BMGs, it is necessary to investigate formation of shear bands and related deformation. Nano-indentation studies with a spherical indenter were carried out to characterise shear-band localisation on a surface of Zr-Cu-based metallic glass. The load-displacement diagram of an indentation cycle reflects an elastic deformation followed by the first pop-in at around 4 mN. In addition, an alternative technique is proposed to characterise a plasticity mechanism through the evolution of localised shear bands beneath the indentation – wedge indentation. It is found that a hemicylindrical region of shear bands is formed beneath the indentation zone in this case.
Misuse Detection in Dynamic Spectrum Sharing Wireless Networks Across Multiple Channels

- We propose a spectrum enforcement framework across multiple channels by mobile, crowdsourced agents (also called volunteers), who work in collaboration with a trustworthy infrastructure. The success of spectrum sharing relies on the automated enforcement of spectrum policies. The primary challenge addressed here is to ensure efficient ex post spectrum enforcement. In order to achieve this, we focus on attaining maximum coverage of the area of enforcement and of all channels, and on ensuring reliable and accurate detection of spectrum violation. Maximum coverage of the given area of enforcement is ensured by proposing to divide it into smaller regions using the Lloyd’s algorithm and solving the enforcement problem by a divide and conquer mechanism over the entire area. We determine the qualification of volunteers based on their likelihood of being in a region, and on their trustworthiness. We define algorithms to select qualified volunteers for every region in an online manner such that every channel is efficiently covered. The enforcement framework is simulated in CSIM19 (C++ version) and extensive analysis of the performance of the proposed methodologies is performed.
Selectable Mutant Phenotypes of the Extremely Thermophilic Archaebacterium Sulfolobus acidocaldarius

As a first step toward developing the genetic potential of extremely thermophilic archaebacteria, mutant strains of Sulfolobus acidocaldarius were selected by plating cells directly on solid medium containing one of several growth inhibitors. Three spontaneous resistance phenotypes were observed (5-fluorouracil resistance, novobiocin resistance, and L-ethionine resistance), each at a different average frequency. Characterization of representative strains showed each of the three mutant phenotypes to provide a potentially useful genetic marker.
Role of Uncertainty

We present a partial equilibrium, two-country portfolio balance model in a monetary union where investors hold savings in risk-free cash and risky bank deposits and stocks. The model predicts a positive relation between relative bank deposits and future output uncertainty. This, however, weakens, and may even become negative, as uncertainty increases, prompting portfolio reallocation from domestic bank deposits towards foreign bank deposits and risk-free cash. We test the model’ predictions in a panel of ten EMU countries using monthly data covering January 1999 to July 2016. Using fixedand time-varying parameter panel models we obtain empirical evidence consistent with the model’s predictions. Our findings support the introduction of a single European Deposit Guarantee Scheme to ensure a healthy pool of private bank deposits in EMU member-states, facilitating national output stabilisation in the event of asymmetric economic shocks and balanced growth across the whole of the EMU. JEL classification: F30; F36; F45; G11; G15
RMHP_A_267492 1279..1291

Department of Pharmaceutics, College of Pharmacy, Najran University, Najran, Kingdom of Saudi Arabia Introduction: The accelerated transformation in the healthcare system supported by the Saudi Vision 2030 makes the present the best time to start the real application of pharmacogenomics in Saudi Arabia. The current study aimed to assess the knowledge, perception and the application status of pharmacogenomics among pharmacists in the hospital settings in Saudi Arabia. Methods: This cross-sectional observational survey was conducted among 206 qualified pharmacists working in Saudi hospitals. A self-administered questionnaire was sent to all participants. Results: Only 30% of the pharmacists had received any type of formal training on PGx. Of these, only nine participants had actually put the knowledge into practice. Participants showed a moderate to low level of knowledge when responded to the pharmacogenomic knowledge indicators used in the study. The low knowledge and the availability of the pharmacogenetic test are the main barriers for the low adoption of the pharmacogenomics in the clinical practice. Approximately 83% felt the need to know more about pharmacogenomics. Participants show positive perception with high motivation levels to incorporate this technology in practice. For example, 76% stated that pharmacogenetic testing should be applied to pharmacy practice. Around 38% of participants reported that the Saudi government and the Saudi FDA had been promoting the pharmacogenomics. However, 50% of the total participants reported that their hospital management is unaware of the pharmacogenomics importance in clinical practice. Discussion: This study emphasizes on two needs which can help promote the use and implementation of pharmacogenomics. One is the need to update the pharmacy education and training programs with pharmacogenomic-related areas to raise the pharmacist’s knowledge and practical skill to apply pharmacogenomics in the clinical practice effectively. Another need is to increase the awareness of the decision and policy-makers with the importance of pharmacogenomics for the patient benefit and safety. This preliminary evaluation will provide future insight into the best approach to applying pharmacogenomics in the Saudi healthcare system.
Impactofaminoacid changes in thesignal peptideonthesecretion oftheTat-dependent xylanaseCfromStreptomyces lividans

Xylanase C (XlnC) is a cofactorless protein secreted through the twin arginine translocation (Tat)-dependent secretion pathway by Streptomyces lividans. Its signal peptide contains the SRRGFLG sequence, which is similar to the twinarginine consensus motif. The 49 amino acid-long signal peptide was analyzed by random, site-directed and site-saturation mutagenesis and the effect of these mutations on XlnC secretion determined. None of the mutations abolished XlnC production and the decreased yields were attributed to the low processing rate of precursors ranging from 2 to 5 h instead of 11 min for the wild-type precursor. Replacement of phenylalanine in the consensus motif by other amino acid residues decreased XlnC secretion by 75%, except for a tryptophan substitution which demonstrated a 50% decrease. Charge distribution in the n-domain of the signal peptide was more important than the net charge. Replacement of the signal peptidase recognition site A-H-A by either A-H-E, V-D-S or R-L-E did not affect precursor processing, indicating that the presence of the conserved residues found in the signal peptidase recognition site is not a prerequisite for the processing of Tat-substrates as it is for the processing of Sec-substrates in S. lividans.
Measurement and Modeling of Temporal Variations of the Indoor Radio Channel

The results of Doppler spread and envelope fading based on CW measurements in the indoor radio channel are presented in this work. In this work, the temporal variations in the channel are caused by a moving receiver, or moving people in the vicinity of the transmitter and receiver. The result of the channel temporal variations is signal fading. The rate of fading can be measured by the Doppler spread. CW measurements were taken at different carrier frequencies from 14 to 14.5 GHz with an increment of 50 MHz. Different locations, antenna separation distances and positions (LOS or NLOS) were selected to collect the data. Each measurement consists of 2.5 seconds of temporal variations of the channel. The autoregressive spectral estimation method is used as a. tool to estimate the Doppler spread using CWmeasurements in the indoor radio channel. Results demon­ strated that this method provided good estimates of the Doppler spread. with a re�on­ able resolution and smoother spectrum than traditional spectrum estimation methods. The values of the Doppler spread under different measurement conditions are com­ pared. Statistical analysis of envelope fading distributions based on the K-S and Chi­ Square goodness tests and level crossing rates are presented. Those results can be used in future designs of wireless communication systems.
Gratitude contemplation as a method to improve human well- being and physical functioning: theoretical review of existing research

Research in positive psychology aims to find and develop diverse ways to improve human wellbeing and the psychophysical functioning (Fredrickson, 2008; Seligman, 2002; Sheldon & Lyubomirsky, 2006). As an example, the studies regard such concepts as positive emotions, character strengths or meaning in life. One of the most frequently studied constructs is also gratitude, that is regarded as the appreciation of all what is meaningful, as well as valuable, to oneself (Sansone & Sansone, 2010). Also, the social aspect of being grateful, and the effects of gratitude on one’s health and physical functioning, are frequently emphasized (McCullough, Kimeldorf & Cohen, 2008; Fox, Kaplan, Damasio and Damasio 2015; Algoe, Haidt & Gable, 2008). Among great amount of work about general gratitude already, there is still little research about gratitude contemplation, one of the exercises that enable a person experiencing gratitude in form of meditation. In this article, first I explain the meaning of the gratitude construct and its impact on peoples psychophysical state in general. Then, I analyze one of the newest gratitude activity, that is gratitude contemplation, its definition, the way of use and the results of recent empirical studies worldwide. Finally, I critically discuss the findings and conclude with future steps for further research on gratitude contemplation. I believe that the results and analysis presented in the article create a base for further research in the area of positive psychology.