Miracle-dz/UniFAR-FTUs huggingface dataset:
Regional Blood Flow Alterations Following Pediatric Concussion: A PedCARE Substudy

Background: This study examined whether cerebral blood flow (CBF) differed between children with concussion and orthopedic injury (OI) controls at 72 hours and 4 weeks post-injury. It also examined whether psychological resilience and acute CBF improved prediction of 2and 4-week concussion symptoms beyond the existing 5P score prediction tool. Methods: Concussed and OI participants, aged 10-18 years, were enrolled from CHEO’s Emergency Department. Arterial spin labelling was used to measure CBF at 72 hours and 4 weeks post-injury. Symptoms were assessed using the Health and Behaviour Inventory at 2 and 4 weeks. Self-reported psychological resilience was measured with the Connor-Davidson Resilience Scale. Crude and adjusted mixed model analyses were conducted to assess absolute CBF (aCBF) and normalized aCBF in both groups over time. Multiple regression analyses assessed whether the 5P score, regional CBF, and resilience combined predicted 2and 4-week symptoms for the concussion group. Results: A total of 70 participants with concussion (Mage=13.05±2.02, 47% female) and 29 with OI (Mage=12.59±1.97, 41% female) were included. For aCBF, a significant group*time interaction was found in the left anterior cingulate/medial frontal cortex (L_ACC_MFC) and right middle frontal gyrus (R_MFG). In the L_ACC_MFC, the concussion group showed increased CBF compared to OIs both time points (p<.001). In the R_MFG, CBF was increased compared to OIs at 4 weeks (p<.001), but not 72 hours. In both regions, CBF increased over time in the concussion group (p≤.001), but did not differ between time points for OIs. Concussed participants also had increased CBF in the left angular gyrus (L_angular) that did not differ between time points. For normalized aCBF, the concussion group displayed significantly
Rewiring Lipid Metabolism by Targeting PCSK9 and HMGCR to Treat Liver Cancer

Simple Summary We targeted abnormalities in lipid metabolism of liver cancer cells and showed that tumoral addiction to lipids can be potentially overridden by available drugs. Anti-PCSK9 alone or in combination with statin treatment can live up to this challenge and disrupt the process of oncogenesis opening up new avenues for potential drug repositioning for the treatment of liver cancer. Abstract Alterations in lipid handling are an important hallmark in cancer. Our aim here is to target key metabolic enzymes to reshape the oncogenic lipid metabolism triggering irreversible cell breakdown. We targeted the key metabolic player proprotein convertase subtilisin/kexin type 9 (PCSK9) using a pharmacological inhibitor (R-IMPP) alone or in combination with 3-hydroxy 3-methylglutaryl-Coenzyme A reductase (HMGCR) inhibitor, simvastatin. We assessed the effect of these treatments using 3 hepatoma cell lines, Huh6, Huh7 and HepG2 and a tumor xenograft in chicken choriorallantoic membrane (CAM) model. PCSK9 deficiency led to dose-dependent inhibition of cell proliferation in all cell lines and a decrease in cell migration. Co-treatment with simvastatin presented synergetic anti-proliferative effects. At the metabolic level, mitochondrial respiration assays as well as the assessment of glucose and glutamine consumption showed higher metabolic adaptability and surge in the absence of PCSK9. Enhanced lipid uptake and biogenesis led to excessive accumulation of intracellular lipid droplets as revealed by electron microscopy and metabolic tracing. Using xenograft experiments in CAM model, we further demonstrated the effect of anti-PCSK9 treatment in reducing tumor aggressiveness. Targeting PCSK9 alone or in combination with statins deserves to be considered as a new therapeutic option in liver cancer clinical applications.
Comparison of Solid Waste Generation During and Before Pandemic Covid-19 in Indonesia Border Island (Riau Islands Province, Indonesia)

Waste in the archipelagic border area must be appropriately managed to maintain diplomatic relations. Indonesia's Riau Islands Province is an archipelagic region in Indonesia with limited solid waste infrastructure development. The capacity of the waste infrastructure depends on the rate of waste generation and is influenced by the socioeconomic conditions of the community. This study aims to study the model for estimating the rate of waste generation in the Riau Islands. This study uses data before and during the Covid-19 pandemic in 2019 and 2020. The estima-tion model uses a multiple linear regression model with independent variables such as gross regional domestic product, access sanitation, total population, and human development index. The fixed variable is the incidence of waste generation rate. During the pandemic Covid-19, the generation and composition of waste in the Riau Islands Archipelago did not experience significant changes, so the waste generation and composition characteristics are the same. However, the variable human development index (0.053) and the population (0.012) significantly increase the waste generation rate. The gross regional domestic product (0.017) negatively correlates, reducing the waste generation rate. The Riau Islands, which has an ocean area of 96%, is a source of life and significant to manage because the waste can be released into the ocean. Therefore, management from sources through policies considering the gross regional domestic product, total population, and human development index needs to be considered to reduce waste generation in the archipelago. © 2023, Polskie Towarzystwo Inzynierii Ekologicznej (PTIE). All rights reserved.
Functional outcomes of intersphincteric resection in low rectal tumors.

Objectives Currently, sphincter-saving procedures are increasingly performed in the treatment of low rectal cancers. This study aimed to evaluate the outcomes of patients who underwent intersphincteric resection. Material and Methods This was a single-center, retrospective, cross-sectional study. We evaluated the electronic data files of 29 patients who had intersphincteric resections at our institute between 2008 and 2018. Bowel function outcomes were assessed prospectively using Wexner incontinence score. Histopathological, surgical and functional outcomes were analyzed. Results Mean age of nine female and 20 male patients included in the study was 55.8 ± 12.8 (30-76) years. A tumor-free surgical margin was achieved in all patients. Anastomotic leakage was detected in two patients. Mean Wexner incontinence score of 20 patients who still had functional anastomosis was 8.35, whereas 65% of the patients (n= 13) had a good continence status. There was no relationship between the continence status and sex, tumor distance from anal verge, T stage, distal surgical margin, and lymph node involvement. Twenty-one patients underwent primary coloanal anastomosis and eight patients underwent two-stage coloanal anastomosis. Conclusion In the treatment of distal rectal cancer, adequate oncological surgery and relatively acceptable functional outcomes can be obtained with intersphincteric resection technique in suitable patients.
The role of the novel adipokines vaspin and omentin in chronic inflammatory diseases

Obesity is a disease of epidemic proportions in many countries around the world. White adipose tissue is an active endocrine organ; therefore, its excess results in chronic and systemic inflammation. This inflammation is caused and maintained mostly by adipokines secreted by adipose tissue cells, mainly adipocytes and macrophages. The relatively newly discovered adipokines comprise vaspin and omentin. Their concentration in the blood, tissues, or bronchial secretion varies depending on the amount of adipose tissue and other accompanying factors, including comorbidities. The aim of this article is to demonstrate the usefulness of omentin and vaspin as biomarkers in inflammatory diseases. The Medline/PubMed database was used to search for information on obesity, inflammation, omentin, vaspin, and adipose tissue. Data from selected scientific studies, both original and review papers, are presented. Vaspin has been found to improve insulin sensitivity mainly in white adipose tissue. Omentin has an anti-inflammatory effect and, like vaspin, sensitizes tissues to insulin. The serum concentration and tissue expression of both adipokines are different in different inflammatory diseases. This review aims to present the biological functions of vaspin and omentin in the body and to indicate the possible use of these adipokines as disease markers in the future.
Solidification and Pion Condensation in Nuclear Medium Alternating-Layer-Spin Structure with One-Dimensional Localization Accompanying π0 Condensate

Localization of nucleons and TC0 condensation in nuclear medium are studied in a unified way, by adopting two kinds of descriptions; namely in the potential description with the OPEP and in the description with explicit use of the pion field coupled to the nucleon field by the (a·/1) interaction. The equivalence of these two descriptions shown in the mean field approximation provides an important starting point. In the former description, the strong tensor force of the OPEP brings about the one-dimensional solid-like structure in which nucleons localize to form the layers with their spin directions aligned perpendicular to the layers and changing in alternation layer by layer. We abbreviate this to [ALS] (Alternating-Layer-Spin) structure. In the latter description, the condensed TC0 field is realized by the source function with the spin-density periodicity given by this nucleon [ALS] struc­ ture. Mechanism of energy gain in such a new phase is clarified by showing that the con­ densation energy overwhelms the increase of nucleon kinetic energy due to localization. Exchange effect, which is ignored in the usual mean field approximation, is not negligible. However, it becomes small if the a-function part of the OPEP is removed. The nucleon system suddenly turns into a well-localized state as the density exceeds the critical value near the normal density po. This means the growth of "solidification" accompanying the TC0 condensation at the density higher than po and also indicates a wide range of validity of our model starting from the nucleon [ALS] structure.
Minds Think Alike: How Do Food Delivery Mobile Applications Innovate Consumer Service

Food delivery mobile applications, such as UBER’S EATS and FOODPANDA mobile apps, are supported by real-time consumer transportation. The study will explain the importance of food delivery mobile apps to affect consumers’ continuance usage intention. A model with relative advantages was provided from the perspective of emotions, uses, and gratifications theory, and data collection using a food delivery mobile app that provided a survey with a hyperlink so that users would relate their experience to its use. 3,000 hyperlinks of invitations to the survey were sent out, with 431 returned. The design and relative service advantages significantly impact users, resulting in improved usage intention for mobile apps. One of the benefits is that the food delivery mobile app offers immediate services to help consumers, such as delivery or transportation. To increase efficiency, innovative food delivery mobile app link hospitality industries that achieve a one-stop service that fulfills user demand for their consumers; When the mobile app-enabled to provide precision and valuable information and create an innovative service assistant, such as a global position system and expected route of taxi and the cost, which better fulfill user needs and often leads to a higher appraisal than the previous service and enhances user intention.
Random effects Cox models: A Poisson modelling approach

We propose a Poisson modelling approach to random effects Cox proportional hazards models. Specifically we describe methods of statistical inference for a class of random effects Cox models which accommodate a wide range of nested random effects distributions. The orthodox BLUP approach to random effects Poisson modeling techniques enables us to study this new class of models as a single class, rather than as a collection of unrelated models. The explicit expressions for the random effects given by our approach facilitate incorporation of relatively large number of random effects. An important feature of this approach is that the principal results depend only on the first and second moments of the unobserved random effects. The application of proposed methods is illustrated through the reanalysis of data on the time to failure (tumour onset) in an animal carcinogen esis experiment previously reported by Mantel and Ciminera (1979).
Void shape evolution and formation of silicon-on-nothing structures during hydrogen annealing of hole arrays on Si(001)

We have studied the structural evolution of voids in the Si substrate and the formation of silicon-on-nothing (SON) structures upon spontaneous reshaping of square arrays of cylindrical holes on Si(001) substrates by hydrogen annealing. Vertically elongated voids covered with {111}, {100}, {110}, and {113} facets are initially formed by the closure of the hole inlets. This step is followed by volume preserving shape changes of the faceted voids in the bulk Si. In situations where the hole-hole separation is sufficiently small, void coalescence occurs due to the shape changes of individual voids, leading to the formation of a SON structure. Until void coalescence, the shapes of individual voids change without being affected by the adjacent voids. Numerical simulations of the shape change of a completely faceted void via solely surface diffusion have been performed and have reproduced the observed shape change.
The Influence of Macroeconomic Factors and Financial Performance on Dividend Policy During Pandemic (Manufacturing Company Listed on the IDX)

This study aims to analyze the influence of macroeconomic factors and financial performance on dividend policy during the pandemic in manufacturing companies listed on the IDX. Shareholders have an interest in obtaining periodic returns on their investments in the form of dividends distributed by the company. The variables used in this macroeconomic factor are inflation, interest rates, and the rupiah exchange rate h. In order to be able to distribute dividends, companies must also have healthy financial performance. The influence of financial performance as reflected in financial ratios in terms of profitability, capital and liquidity which in this case is reflected in the ratio of Return on Assets (ROA), Return On Equity (ROE), Debt to Equity Ratio (DER ), Earning Per Share (EPS) . The population in this study are all manufacturing sector companies listed on the Indonesia Stock Exchange. This research uses multiple regression analysis processed with EVIEWs . The results of this study indicate that the macroeconomic factors in the form of the inflation rate and the interest rate have no significant effect on the dividend policy of manufacturing companies on the Indonesia Stock Exchange. Financial performance factors show that ROA, ROE, and EPS have a significant effect on dividend policy for manufacturing companies on the Indonesia Stock Exchange.
Neoadjuvant famitinib and camrelizumab, a new combined therapy allowing surgical resection of the primary site for anaplastic thyroid carcinoma

Anaplastic thyroid cancer (ATC) is considered the most lethal thyroid cancer, with an overall 5‐year survival rate below 10%. The FDA approved a BRAF/MEK inhibitor combination for the treatment of patients with BRAF‐mutated ATC. However, effective therapeutic options for patients with wild‐type BRAF are lacking.
Estimation of stream water components and residence time in a permafrost catchment in the central Tibetan Plateau using long-term water stable isotopic data

Abstract. Global warming has significantly impacted the hydrological processes and ecological environment in permafrost regions. Mean residence time (MRT) is a fundamental catchment descriptor that provides hydrological information regarding storage, flow pathways, and water source within a particular catchment. However, water stable isotopes and MRT have rarely been investigated due to limited data collection in the high-altitude permafrost regions. This study uses the long-term stable isotopic observations to identify runoff components and applied the sine-wave exponential model to estimate water MRT in a high-altitude permafrost catchment (5300 m a.s.l.) in the central Tibetan Plateau (TP). We found that the isotope composition in precipitation, stream, and supra-permafrost water exhibited obvious seasonal variability. The freeze–thaw process of the permafrost active layer and direct input of precipitation significantly modified the stable isotope compositions in supra-permafrost and stream water. The hydrograph separation revealed that precipitation and supra-permafrost water accounted for 35 ± 2 % and 65 ± 2 % of the total discharge of stream water, respectively. MRT for stream and supra-permafrost water was estimated at 100 and 255 d, respectively. Such shorter MRTs of supra-permafrost and stream water (compared to the non-permafrost catchments) might reflect the unique characteristics of the hydrological process in permafrost catchments. Moreover, the MRT of supra-permafrost water was more sensitive to environmental change than that of stream water. Climate and vegetation factors affected the MRT of stream and supra-permafrost water mainly by changing the thickness of the permafrost active layer. Our results suggest that climate warming might retard the rate of water cycle in permafrost regions. Overall, our study expands our understanding of hydrological processes in high-altitude permafrost catchments under global warming.
THE COVID-19 PANDEMIC AS AN OPPORTUNITY TO BRING THE MIGRATION OF AGRICULTURAL WORKERS INTO FOCUS THROUGH MEDIA COVERAGE

In recent years, the interest in media representations of migrants and the media as a space for participation has increased within the field of migration studies. Yet, most scholars’ attention is focused on immigrants and the media in destination countries, while less attention is paid to origin countries and emigrants’ representation. Taking advantage of the increased attention paid to migrants and migration during the first phase of the COVID-19 pandemic, we investigated the media representations of Romanian migrants in agriculture who work in other European countries and interpreted how their voices could be heard through media accounts. Through content analysis, we investigated a sample of 297 articles published between 1st April and 31st May 2020 on the websites of the six most visible Romanian media outlets. This study contributes to the existing knowledge on media representations of Romanian migrants by documenting a series of tendencies, including an event-oriented approach, oversimplified representations of migration, massification and schematisation of migrant representations, and the high sensitivity to reports from destination countries’ media on Romanian migrants. Our analysis reveals that the approach taken to reporting on migration during the COVID-19 pandemic, at least during its first phase, highly depended on the existing, institutionalised modes of media reporting on migration.
Photon statistics of light fields based on single-photon-counting modules

Single-photon-counting modules (SPCM's), with their high quantum efficiency, have been widely used to investigate effectively the photon statistics of various light sources, such as the single-photon state and emission light from controlled molecules, atoms, and quantum dots. However, such SPCM's cannot distinguish the arrivals of one photon and two (or more than two) photons at a moment, which makes measurement correction in real experiments. We analyze the effect of SPCM's on photon statistics based on the Hanbury-Brown-Twiss configuration when the total efficiency and background are considered, and it shows that the measured second-order degree of coherence and Mandel $Q$ factor for different quantum states, including single-photon states and squeezed vacuum states, are corrected in different forms. A way of determining the squeezing of a squeezed vacuum state based on single-photon detection is presented.
Experimental setup for the measurement of the electrical resistivity and thermopower of thin films and bulk materials

An experimental setup was developed for the simultaneous measurements of the electrical resistivity and the thermopower in the temperature range going from 77 up to 330K. The system combines accuracy, rapidity, few efforts for the sample mounting, and is fully automated. Pressure contacts are used for contacting the thermocouples to the sample and the sample to the heat sink, making possible the measurement of both thin films and bulk materials with a great flexibility on their geometrical dimensions. Tests of the system have been made on a 99.98% pure Ni bulk sample and on PbTe∕BaF2 thin films for illustration.An experimental setup was developed for the simultaneous measurements of the electrical resistivity and the thermopower in the temperature range going from 77 up to 330K. The system combines accuracy, rapidity, few efforts for the sample mounting, and is fully automated. Pressure contacts are used for contacting the thermocouples to the sample and the sample to the heat sink, making possible the measurement of both thin films and bulk materials with a great flexibility on their geometrical dimensions. Tests of the system have been made on a 99.98% pure Ni bulk sample and on PbTe∕BaF2 thin films for illustration.
ON c-NORMAL MAXIMAL AND MINIMAL SUBGROUPS OF SYLOW SUBGROUPS OF FINITE GROUPS

A subgroup H is called c-normal in G if there exists a normal subgroup N of G such that HN = G and H ∩ N ≤ HG = CoreG(H). The purpose of this paper is to generalize some results obtained by some authors about supersolvable groups to a saturated formation containing the class of supersolvable groups.
Glottalisation en korebaju : la question d’un trait mixte segmental et suprasegmental

Glottalization in Korebaju: The question of a mixed segmental and suprasegmental feature Korebaju is an Amazonian language from Colombia. Four field surveys conducted between 2017 and 2022 with six speakers of the same village has enabled us to identify a set of glottal productions that appear to fall under the segmental and suprasegmental levels. This study analyzes the production and phonological status of three types of glottalized or glottal segments: five vowels, three of which are phonemic /aˀ, eˀ, oˀ/, an obstruent [ʔ] and a voiced creaky approximant [*]. Based on acoustic analyzes and on a morpheme syllabification task, the glottalization as a vowel feature is confirmed, while the other two segments found only in intervocalic position and unrelated to the glottal vowels would instead involve a suprasegmental feature [constricted glottis] as a syllabification strategy to repair a canonical CV template between two vowels in a hiatus when the first has a low tone and the second, a high tone (V̀1.V́2). MOTS-CLÉS : korebaju, langues tukano, glottalisation segmentale et suprasegmentale.