Miracle-dz/UniFAR-FTUs huggingface dataset:
PPA_A_202173 1037..1050

Rahul Dhanda Della Varghese Vijay R Nadipelli Maurizio Fava Namita Joshi Caitlyn T Solem James A Graham Susan M Learned Christian Heidbreder 1Global Health Economics and Outcomes Research, Indivior Inc, Richmond, VA 23235, USA; 2Real-World Evidence and Data Analytics, Pharmerit International, Bethesda, MD 20814, USA; 3Clinical Trials Network Institute (CTNI), Massachusetts General Hospital (MGH) and Harvard Medical School, Boston, MA 02114, USA; 4Global Medicines Development, Indivior Inc, Richmond, VA 23235, USA; 5Global Research and Development, Indivior Inc, Richmond, VA 23235, USA Purpose: RBP-7000 (PERSERISTM) is a once-monthly subcutaneous extended-release risperidone formulation approved by the United States Food and Drug Administration for the treatment of schizophrenia in adults. The objective of this study was to describe the longterm impact of RBP-7000 on health-related quality of life (HRQoL), subjective well-being, treatment satisfaction and medication preference in patients with schizophrenia. Patients and methods: HRQoL was derived from a 52-week multicentre Phase III singlearm open-label outpatient study that assessed the safety and efficacy of RBP-7000 (120 mg) in patients with schizophrenia. HRQoL was measured using the EuroQol EQ-5D-5L and ShortForm Survey SF-36 version 2; well-being using the Subjective Well-being Under Neuroleptic Treatment – Short Version (SWN-S); satisfaction using the Medication Satisfaction Questionnaire and medication preference using the Preference of Medication questionnaire. Results: Of 482 participants at baseline, 234 remained through the end of study (EOS; week 52). Mean HRQoL and well-being scores remained stable between baseline (EQ-5D-5L index: 0.83; SF-36v2 Physical Component Score: 50; SF-36v2 Mental Component Score: 46; total SWN-S score: 89) and EOS (EQ-5D-5L index: 0.86; SF-36v2 Physical Component Score: 49; SF-36v2 Mental Component Score: 47; total SWN-S score: 90). The proportion of participants reporting satisfaction increased between week 4 (66%) and EOS (81%), with a similar trend for the preference of RBP-7000 over previous treatment (week 4: 66%; EOS: 72%). Sensitivity analyses suggested a minor effect of dropout on characterization of change over time in patient-reported outcomes (PRO) measures. Conclusion: Study participants attained mean HRQoL scores near that of the general US population. Over two-thirds reported high satisfaction with and preference for RBP-7000 across the study period. Additional research is needed to confirm whether these PRO translate into improved outcomes such as adherence and ultimately fewer relapses in patients with schizophrenia.
A psychodynamic perspective

The Nazi disaster-the most devastating period in German history for the lives, the culture, and the souls it ruined-is still only a marginal subject in German psychological research. In fact, up to the early 1980s, there were hardly any scientific publications. There are probably three reasons for the lack of research about this topic in Germany: ( 1) the long time of latency between the end of the Nazi area in 1945 and the beginning of the investigations in the 1980s; (2) the absence of theory to conceptualize the research data; and (3) the fact that all the investigators in Germany are part of the problem they are investigating. Only after a long period oflatency, starting in the early 1980s, have there been German investigations about "Children of Nazis. " In 1982, for the first time, German scientists wrote on this topic in the American publication Generations of the Holocaust (Bergmann & Jucovy, 1982; Eckstaedt, 1982; Hardtmann, 1982; Rosenkotter, 1982). 1t took another 13 years until a German publisher took the risk to translate and republish in Germany extracts from this important book. Peter Sichrovski published his moving interviews with children of Nazis in 1987. And strong media interest was roused in Germany when Niklas Frank displayed in public the conflict with his father, who had been the chief of Generalgouvernemt Poland from 1939 untill945, and had been sentenced to death in 1946 (Frank, 1987). Dorte von Westernhagen (1987), a German journalist, conducted considerable research over several years in order to reconstruct the biography of her father, who had been a member of the Leibstandarte Adolf Hitler and had died as a soldier toward the end of the war. In a very vivid and sensitive way, the reader received an example of how the second generation labored to save what could be saved from the ruins of the Third Reich. The desire to comprehend her father, to get access to the inconceivable, to do justice to him and to her own wishes and disappointed longings, were laid open. For years, Bar-On interviewed children of leading Nazis. He listened to them, individually and in groups, starting out with entirely German groups, later counseling mixed groups of the second and third generation of German children of persecutors and Jewish children of survivors from the United States and Israel. He described in detail the everyday experiences of the
Thyroid dysfunction and Meniere’s disease: is there a relationship? BY TIMOTHY HAIN AND PATTHIDA MAROONGROGE

M eniere’s disease (MD) affects around two in 1000 people and is one of the most common causes of dizziness deriving from the inner ear. Although MD is nearly always accompanied with endolymphatic hydrops (See Figure 1), temporal bone studies find hydrops in a far greater proportion of normal temporal bones than would be expected from the prevalence of Meniere’s disease in the population. Accordingly, the aetiology of MD is believed to be multifactorial. Metabolic and endocrine dysfunction, as well as autoimmune disturbance, have been suggested to be contributing factors to causation of MD. In particular, there is evidence in the literature that thyroid disorders, specifically hypothyroidism and autoimmune thyroiditis, play a role in MD [1-3, 5]. Hypothyroidism is a common endocrine problem in which the thyroid gland fails to produce sufficient thyroid hormone, leading to reduced body metabolic functions. Previous researchers evaluating metabolic factors in MD proposed that hypothyroidism is the aetiology of MD in a small proportion of the cases. In 1978, Powers found that 17 of 98 patients with MD were hypothyroid, and in three of these patients, symptoms of MD were successfully controlled by thyroid hormone therapy alone [1]. Powers suggested that thyroid hormone deficiency was responsible for symptoms of MD in these patients. However, other investigators later did not support this idea as they found low prevalence of hypothyroidism in patients with MD. Kinney reported that only two of their 180 patients with MD had hypothyroidism [2]. Therefore, it is unlikely that hypothyroidism, per se, is a cause of MD. Additional evidence that the thyroid may play a role in MD came from the study of Brenner and associates in 2004 [3]. They reported that the proportion of treated hypothyroidism was 32% in the group of 50 patients with MD, as opposed to 4% in the control group. In addition, the prevalence of thyroid hormone supplement use was even higher (50%) in MD patients older than 60 years old. In the US and other countries where there is no iodine shortage, autoimmune thyroiditis, also known as Hashimoto’s thyroiditis (see Figure 2) is the most common cause for hypothyroidism [4]. Because none of the patients in this study had a history of iatrogenic hypothyroidism, such as thyroidectomy, it was assumed that the cause of their thyroid hypofunction was autoimmune thyroiditis [3]. The association between MD and autoimmune thyroiditis was later supported by a study on thyroid autoimmunity and Thyroid dysfunction and Meniere’s disease: is there a relationship?
Front Crash Injury Risks for Restrained Drivers in Good-rated Vehicles by Age , Impact Configuration , and EDR-based Delta V

The risk of injury in a front crash depends on both severity and impact configuration, but the accuracy of crush-based estimates of the former depends on the latter. In the current study, output from event data recorders (EDRs) was used to establish estimates of configuration-specific severity and real-world injury risk in crashes similar to consumer test programs. NASS-CDS was queried for all front crashes of vehicles with good IIHS 40% overlap crash test ratings in which the driver was restrained by a belt and deployed front airbag. Vehicles with a complete EDR crash pulse (n=764) or crush-based delta-V calculated from vehicle-specific stiffness values (n=1902) were assigned a crash configuration through photographic review. Cases with delta-Vs from both methods were used to establish configuration-specific EDR-equivalent delta-Vs. The effects of various crash, vehicle, and occupant factors on injury risk were estimated using logistic regression. For large overlaps, moderate overlaps, and center impact crashes, driver age and delta-V had strong effects on the risk of sustaining an MAIS≥3 non-extremity or fatal injury. Vehicles with good ratings in the IIHS moderate overlap test still allow high risk of serious injury in real-world crashes with severities similar to the crash test, especially to older drivers.
An Event History Analysis of the Stock Return-An Empirical Study on Taiwan Stock Market

Although CAPM has been comprehensively applied on practice for a long time, it is established under the perfect-basis assumption which does not always exist in reality because there are several factors affecting the capital return. Hence, the actual performance of the CAPM model has been questioned. There have been numerous proposals in improving the performance of the model. This study aims at finding the actual correlation of price/book ratios effect and stock return, investors may anticipate whether a certain stock will be transformed between growth stocks and value stocks, and buy/sell such stock to make profits in the future. Based on monthly data from listed companies on Taiwan stock market from 1991-2010, it is found that higher price/ earnings ratio generates high possibility in transformation and expected return increase. Therefore, investors should apply influence factors of variables to models in order to explore stock-selection strategy. The investment methods from this research could be a new stock-selection strategy for investors' excess return and better investment performance. Key-Words: CAPM Model, capital return, growth stock, value stock, stock selection
Effects of Deoxyschisandrin on Visceral Sensitivity of Mice with Inflammatory Bowel Disease

The aims of this study were to build an IBD mouse model and further to observe the effects of deoxyschisandrin on IBD and visceral sensitivity and to evaluate the relevance of brain-derived neurotrophic factor (BDNF) to intestinal hypersensitivity of IBD mice. The results showed that deoxyschisandrin could depress the contraction of isolated smooth muscle, modulate gastrointestinal function, and efficiently decrease the disease activity index (DAI) of IBD mice, which proved that deoxyschisandrin had antidiarrheal effects on the animals. In the colorectal distention (CRD) experiment, visceral sensibility was increased in the model group. However, abdominal withdrawal reflex (AWR) scores were decreased after deoxyschisandrin intervention, indicating that deoxyschisandrin could reduce the visceral hypersensitivity of IBD mice. Both IHC observation and western blotting analysis showed that BDNF protein expression increased evidently in colon of IBD mice. After the intervention of deoxyschisandrin, colon mucosa BDNF protein expression in IBD mice decreased, indicating that deoxyschisandrin could decrease mouse intestinal sensitivity by reducing colon mucosa BDNF expression. In conclusion, deoxyschisandrin possessed antidiarrheal effects and visceral hypersensitivity inhibitory effects in the mice with IBD induced by TNBS, which was related to the reduction in BDNF expression in the colon.
Fiscal reaction function and fiscal fatigue: evidence for the euro area

This paper estimates a fiscal reaction function (FRF) framework for euro area countries and derives a novel approach to measure fiscal fatigue. As in previous studies, we find evidence that euro area sovereigns abide, on average, by (weak) sustainability constraints. The primary balance improves by about 0.03–0.05 for every 1 percentage point increase in the debt-to-GDP ratio after controlling for other relevant factors. The positive reaction of primary surpluses to higher debt strengthened over the crisis. Based on this framework, we propose a simple, practical measure of fiscal fatigue that can be used to assess the capacity of sovereigns to maintain primary surpluses over extended periods of time. This measure can be derived by comparing simulated primary balance paths in the context of debt sustainability analyses with countries’ track-record, adjusted for the change in debt with the estimated fiscal reaction coefficient. The evidence of fiscal fatigue in non-linear FRF specifications is weaker for our euro area sample. JEL: H60, E62, F41, C33
OAJSM_A_180409 171..183

Fionn T McSwiney Lorna Doyle 3 Daniel J Plews Caryn Zinn 4 1School of Health and Human Performance, Dublin City University, Dublin, Ireland; 2Setanta College, Thurlus, Tipperary, Ireland; 3Department of Sport and Exercise Science, Waterford Institute of Technology, Waterford, Ireland; 4Sports Performance Research Institute New Zealand (SPRINZ), Auckland University of Technology, Auckland, New Zealand Abstract: The impact of a ketogenic diet (KD) (<50 g/d carbohydrate, >75% fat) on athletic performance has sparked much interest and self-experimentation in the past 3–4 years. Evidence shows 3–4-week adaptations to a KD in endurance-trained athletes were associated with maintenance of moderate (46–63% VO2max) and vigorous intensity (64–90% VO2max) endurance exercise, while at intensities >70% VO2max, increases in fat oxidation were associated with decreased economy (increased oxygen consumption), and in some cases, increased ratings of perceived exertion and heart rate. Two investigations in recreationally active endurance athletes noted no vigorous intensity exercise decrement following 3and 12-week adaptations. Moderate (70–85% one repetition maximum) and near-maximal to maximal intensity (>85% 1RM) strength performance experienced no decrement following a 3-12-week KD adaptation. Beneficial effects were noted for 2000 m sprint and critical power test completed for short duration at vigorous intensity, while two additional tests noted no decrement. For sprint, near-maximal exercise (>91% VO2max), benefit of the KD was observed for six-second sprint, while no decrement in performance was noted for two additional maximal tests. When protein is equated (grams per kilogram), one investigation noted no decrement in muscle hypertrophy, while one noted a decrement. One investigation with matched protein noted the KD group lost more body fat. In conclusion, moderate-tovigorous intensity exercise experiences no decrement following adaptation to a KD. Decreases in exercise economy are observed >70% VO2max in trained endurance athletes which may negate performance within field settings. Beneficial effects of the KD during short duration vigorous, and sprint bouts of exercises are often confounded by greater weight loss in the KD group. With more athletes pursuing carbohydrate-restricted diets (moderate and strict (KD)) for their proposed health benefits, more work is needed in the area to address both performance and health outcomes.
Early pregnancy after bariatric surgery: a single-institute preliminary experience

Background/aim Pregnancy after bariatric surgery is an issue of growing importance with increasing number of women undergoing bariatric surgery. Therefore, in this study we present patients who conceived after sleeve gastrectomy and evaluate the obstetric outcomes. Materials and methods This retrospective case-control study includes 23 women who conceived after laparoscopic sleeve gastrectomy. Patients were evaluated in two groups according to the number of months between surgery and conception (group 1: ≤12 months; group 2: >12 months). Results The mean body mass index of patients before surgery and at the time of conception was 46.6 kg/m2 and 29.7 kg/m2, respectively. Nine patients (39.1%) had a history of infertility. There was no statistical difference between groups 1 and 2 for haemoglobin, ferritin, and 25-OH Vit-D levels or maternofoetal complication rates and pregnancy outcomes. Enteral nutrition requirements and intravenous iron replacement needs were higher in group 1, although this difference was not statistically significant. Conclusion Pregnancy in the first years after sleeve gastrectomy seems to have similar obstetric outcomes compared to pregnancies occurring later, but it remains a controversial issue. Although the results did not have statistical significance in our study, well-designed prospective series may determine the role of enteral nutrition and intravenous iron replacement in patient management.
An Evaluation of the Antioxidant Properties of Propolis against Fenvalerate-induced Hepatotoxicity in Wistar Rats

Fenvalerate is a synthetic pyrethroid pesticide used extensively in agriculture to protect a wide variety of crops. Propolis is a natural product produced by honey bees and is used widely in traditional medicines for its antioxidant properties. The present work evaluates the effects of fenvalerate administration on albino rats’ liver and possible ameliorative roles played by propolis treatment. Fenvalerate treatment has induced histological changes in the liver of albino rats including the congestion of blood vessels, cytoplasmic vacuolization of the hepatocytes, necrosis and fatty degeneration. Biochemical analyses showed that fenvalerate caused a remarkable increase in the level of alanine aminotransferase (ALT), aspartate aminotransferase (AST), urea and creatinine, and a decrease in the total number of white blood cells (WBCs) and platelets. It also caused an increase in malondialdehyde (MDA) and depletion in the activity of the antioxidant enzymes, catalase (CAT), and superoxide dismutase (SOD) in the liver of rats. However, treating animals with fenvalerate followed by a propolis treatment led to an improvement in both histological and biochemical alterations induced by fenvalerate. The rats that were treated with fenv/propolis showed a dramatic improvement in the level of ALT, AST, urea and creatinine, WBCs, and platelets. Moreover, propolis was found to reduce the level of malondialdehyde and increase the activity level of antioxidant enzymes, SOD and CAT. In conclusion, propolis might be considered as a natural effective agent to eliminate the toxicity caused by fenvalerate, due to its antioxidant activity.
Effect of Health Promoting School Program in Schools of the City of Babol :2013

Background & objectives: Investing in the health of adolescents and youth population in educational environments is one of the most important interventions in the health sector. This study aims to evaluate the percentage of improvement of the Health Promoting School program in schools under the coverage of the city of Babol. Methods: This study was a before and after the intervention conducted in 2013. The research population and samples were selected by census from 63 health program executor schools in the city of Babol. The data collection tool was standard Checklist to evaluate health program executor schools in two administrative and 8-fold indices. Data were collected in two phasesbefore and after the intervention- within a month and analyzed by SPSS18 software at the significance level of p 0.05. Results: Of the 63 health program executor schools, (38.1%) 24 were primary schools (27%) 17 guidance schools (34.9%) and 22 high schools, and also (65.1%) 41 urban schools and 33 schools for boys (52.4%). From 100 points, the average point of health program executors was 66.0811.99 before intervention which as promoted to 71.7910.96 after the intervention. There was a significant difference between the total mean score and the mean scores of 9- fold items before and after the intervention (p 0.05). Model results showed that the total checklist Score of the first phase and geographical area is only related to the second check list points and the impact of this program was higher in the rural schools. Conclusion: This study showed that the execution of the health promoter programs has a positive impact in improving school indicators. It is recommended to implement this program in all schools.
Studying the characterisation of deep CNN neurons

This master thesis has studied the characteristics of deep conventional neurons present in a pre-trained Deep Convolutional Neural Network structure based on the GoogleNet network. Three approaches towards finding different behaviours in the architecture have been introduced: supervised approach to find patterns in the neuron weights, an unsupervised kernel clustering method alongside dimensionality reduction for visualisation and Topological Data Analysis on the layer channels. Using the supervised method, we have found a correlation between neurons’ weights and the patterns found in images that excite them most. To understand the neurons behaviour in each layer of the network, Spectral Clustering has been applied in order to group the neurons by their weights. In conjunction with clustering, a dimensional reduction has been performed using UMAP in order to visualise the data in an embedded 2-Dimensional space. As a result, we have found several groups of neurons for each layer. In some cases, when visualising this embedding, a clear circular shape has been found. As a final step, in order to get the insights of the actual layers, a topological data analysis has been performed on the channels of each layer. We have found a ring-shaped graph representing the neurons’ channels present in a layer, which confirms the idea of CNN layers trying to mimic the primary visual cortex. Acknowledgements I have to thank my supervisors, Dario and Javier, for providing assistance during this process. To my family and colleagues, for their comprehension during all this period. To my university friends: Carla, Marçal, Dani and specially to Laura, for all the help and support. To all of them I want to express my wholehearted gratitude.
The Eucharist or the Lord's Supper in the light of the Catholic-Pentecostal dialogue (1972-2015)

The ongoing Catholic-Pentecostal dialogue highlighted a certain disproportion in the approach of each of the parties to the Eucharist or the Lord's Supper. For Pentecost Christians participation in the Lord's Supper is of secondary importance. Common conversations been shown that in Catholic spirituality the Eucharist occupies a significant and central place. It is the presence of the sacrifice that took place once and for all on the cross of Christ. Pentecostals are not unanimous, however, in the meaning of the Lord's Supper. For this community usually the Lord's Supper means only commemoration of Last Supper. They do not believe, however, that during it the bread and wine will transform truly, really, and substantially into the Body and Blood of Christ, which is the fundamental doctrine of the Catholic Church. The presence of the Savior during this rite, according to the Pentecostals, is only spiritual. Although Pentecostal Christians do not attach so much importance to the Eucharist, as Catholics do, nevertheless for the followers of both communities this celebration is an important spiritual experience. This article aims to show similarities and differences in relation to the above issues in the light of the Catholic-Pentecostal dialogue.