Miracle-dz/UniFAR-FTUs huggingface dataset:
2, 3, 5, 4’-tetrahydroxystilbene-2-O-beta-D-glucoside protects against neuronal cell death and traumatic brain injury-induced pathophysiology

Traumatic brain injury (TBI) is a global health issue that affects at least 10 million people per year. Neuronal cell death and brain injury after TBI, including apoptosis, inflammation, and excitotoxicity, have led to detrimental effects in TBI. 2, 3, 5, 4’-tetrahydroxystilbene-2-O-beta-D-glucoside (THSG), a water-soluble compound extracted from the Chinese herb Polygonum multiflorum, has been shown to exert various biological functions. However, the effects of THSG on TBI is still poorly understood. THSG reduced L-glutamate-induced DNA fragmentation and protected glial and neuronal cell death after L-glutamate stimulation. Our results also showed that TBI caused significant behavioral deficits in the performance of beam walking, mNSS, and Morris water maze tasks in a mouse model. Importantly, daily administration of THSG (60 mg/kg/day) after TBI for 21 days attenuated the injury severity score, promoted motor coordination, and improved cognitive performance post-TBI. Moreover, administration of THSG also dramatically decreased the brain lesion volume. THSG reduced TBI-induced neuronal apoptosis in the brain cortex 24 h after TBI. Furthermore, THSG increased the number of immature neurons in the subgranular zone (SGZ) of the dentate gyrus (DG) of the hippocampus. Our results demonstrate that THSG exerts neuroprotective effects on glutamate-induced excitotoxicity and glial and neuronal cell death. The present study also demonstrated that THSG effectively protects against TBI-associated motor and cognitive impairment, at least in part, by inhibiting TBI-induced apoptosis and promoting neurogenesis.
Single‐cell transcriptomics reveals conserved cell identities and fibrogenic phenotypes in zebrafish and human liver

The mechanisms underlying liver fibrosis are multifaceted and remain elusive with no approved antifibrotic treatments available. The adult zebrafish has been an underutilized tool to study liver fibrosis. We aimed to characterize the single‐cell transcriptome of the adult zebrafish liver to determine its utility as a model for studying liver fibrosis. We used single‐cell RNA sequencing (scRNA‐seq) of adult zebrafish liver to study the molecular and cellular dynamics at a single‐cell level. We performed a comparative analysis to scRNA‐seq of human liver with a focus on hepatic stellate cells (HSCs), the driver cells in liver fibrosis. scRNA‐seq reveals transcriptionally unique populations of hepatic cell types that comprise the zebrafish liver. Joint clustering with human liver scRNA‐seq data demonstrates high conservation of transcriptional profiles and human marker genes in zebrafish. Human and zebrafish HSCs show conservation of transcriptional profiles, and we uncover collectin subfamily member 11 (colec11) as a novel, conserved marker for zebrafish HSCs. To demonstrate the power of scRNA‐seq to study liver fibrosis using zebrafish, we performed scRNA‐seq on our zebrafish model of a pediatric liver disease with mutation in mannose phosphate isomerase (MPI) and characteristic early liver fibrosis. We found fibrosis signaling pathways and upstream regulators conserved across MPI‐depleted zebrafish and human HSCs. CellPhoneDB analysis of zebrafish transcriptome identified neuropilin 1 as a potential driver of liver fibrosis. Conclusion: This study establishes the first scRNA‐seq atlas of the adult zebrafish liver, highlights the high degree of similarity to human liver, and strengthens its value as a model to study liver fibrosis.
Is Living with Persons with Dementia and Depression Correlated to Impacts on Caregivers? A Scoping Review

Abstract Caregivers of persons with dementia and depression experience adverse effects associated with their role. The aim of this scoping review was to identify the challenges faced by caregivers of people with dementia and depression, along with interventions to support them. The MEDLINE®, Embase and PsycINFO databases were searched using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) method. Grey literature was assessed using the Canadian Agency for Drugs and Technologies in Health’s Gray Matter tool. The population consisted of caregivers of people with dementia and depression; the concept was to identify the negative impacts that caregivers experience and whether there are interventions to reduce them; the context was any study design targeting family or friends who were caregivers. A total of 12,835 citations were identified; 139 studies were included. Dementia and depression have variable impacts on outcomes experienced by caregivers, including burden/strain (n = 52), depression (n = 27), distress (n = 53), quality of life (n = 5) and health/well-being (n = 9). Pharmacological and non-pharmacological interventions have mixed effects. This study is important considering that depression in people with dementia is associated with caregiver distress. The use of a variety of non-pharmacological interventions could be beneficial to the latter.
State-of-the-art glucocorticoid-targeted drug therapies for the treatment of rheumatoid arthritis

ABSTRACT Introduction Glucocorticoids are steroid hormones broadly used for the treatment of several inflammatory and autoimmune diseases among other numerous indications, including rheumatoid arthritis. Areas covered For the purposes of this article, the authors have performed an extensive review of the literature to present the latest studies on glucocorticoid use in rheumatoid arthritis. They also provide the reader with their expert perspectives on future developments. Expert opinion The authors do not anticipate that glucocorticoids with be replaced in the near future by newer drugs. As such, rheumatologists should be fully aware of the possible side-effects and educate appropriately their patients to recognize and report them. Newer formulations, such as the liposomal/nanoparticle-based treatments, will result in less pronounced adverse effects, but the input of clinical experience along with the current recommendations for the glucocorticoid use will benefit both clinicians and patients with rheumatoid arthritis.
Factors affecting social accountability of medical schools in the Korean context: exploratory factor and multiple regression analyses

ABSTRACT The concept of social accountability of medical schools is becoming increasingly important worldwide, and numerous frameworks and evaluation tools have been developed. This study examined how global concepts work in a specific context by identifying the factors affecting medical schools’ social accountability performance in the Korean context. A survey was conducted with 40 current deans of medical schools and 15 medical education experts in Korea to assess their opinions on the implementation of social accountability of medical schools. A questionnaire survey comprising five key factors, including 39 items, was developed based on a literature review. Exploratory factors were analyzed to derive factors affecting social accountability Multiple regression analysis was conducted to determine the importance of each factor in the implementation of social accountability of medical schools. The exploratory factor analysis revealed that eight factors in three areas influenced the implementation of social accountability by medical schools. The hardware (H) area included the declaration of social accountability and physicians, organizations and systems for implementing social accountability, and physical environment and finance. The software (S) area included curriculum design-related social accountability and monitoring and evaluation system. The partner (P) area included the proximity between partners, building partnerships among stakeholders, and interactions between partners. Multiple regression analysis revealed that ‘interactions between partners’ had the greatest impact on the implementation of social accountability of medical schools. It is a social accountability implementation model that reflects global principles within the Korean context. The HSP model is significant in that individual medical schools can be used in establishing mandated mechanisms for accreditation. Future studies could adapt this model to study standards and indicators in other contexts.
Staring death in the face: chimpanzees' attention towards conspecific skulls and the implications of a face module guiding their behaviour

Chimpanzees exhibit a variety of behaviours surrounding their dead, although much less is known about how they respond towards conspecific skeletons. We tested chimpanzees' visual attention to images of conspecific and non-conspecific stimuli (cat/chimp/dog/rat), shown simultaneously in four corners of a screen in distinct orientations (frontal/diagonal/lateral) of either one of three types (faces/skulls/skull-shaped stones). Additionally, we compared their visual attention towards chimpanzee-only stimuli (faces/skulls/skull-shaped stones). Lastly, we tested their attention towards specific regions of chimpanzee skulls. We theorized that chimpanzee skulls retaining face-like features would be perceived similarly to chimpanzee faces and thus be subjected to similar biases. Overall, supporting our hypotheses, the chimpanzees preferred conspecific-related stimuli. The results showed that chimpanzees attended: (i) significantly longer towards conspecific skulls than other species skulls (particularly in forward-facing and to a lesser extent diagonal orientations); (ii) significantly longer towards conspecific faces than other species faces at forward-facing and diagonal orientations; (iii) longer towards chimpanzee faces compared with chimpanzee skulls and skull-shaped stones, and (iv) attended significantly longer to the teeth, similar to findings for elephants. We suggest that chimpanzee skulls retain relevant, face-like features that arguably activate a domain-specific face module in chimpanzees' brains, guiding their attention.
Asymptotic stability of quasi-periodic orbits

Stability is one of the most fundamental properties of solutions to differential equations and, for example, can explain the presence of harmful vibrations. While the stability type of fixed points and periodic orbits can be assessed with standard tools, no general and reliable method allows to conclude about the stability of quasi-periodic orbits. Here, we overcome this limitation and develop a novel and universal method to rigorously assess the asymptotic stability of quasi-periodic solutions to differential equations. Furthermore, we develop an automated algorithm for such stability investigations and demonstrate its applicability on two explicit mechanical examples.
Limits to the evolution of dispersal kernels under rapid fragmentation

Adaptive evolution of dispersal strategies is one mechanism by which species can respond to rapid environmental changes. However, under rapid anthropogenic fragmentation, the evolution of dispersal may be limited, and species may be unable to adequately adapt to fragmented landscapes. Here, we develop a spatially explicit model to investigate the evolution of dispersal kernels under various combinations of fragmentation dynamics and initial conditions. We also study the consequences of modelling an evolutionary process in which dispersal phenotypes continuously and gradually shift in phenotype space in a manner corresponding to a polygenic underlying genetic architecture. With rapid fragmentation rates, we observed the emergence of long-term transient states in which dispersal strategies are not well suited to fragmented landscapes. We also show that the extent and length of these transient states depend on the pre-fragmentation dispersal strategy of the species, as well as on the rate of the fragmentation process leading to the fragmented landscape. In an increasingly fragmented world, understanding the ability of populations to adapt, and the effects that rapid fragmentation has on the evolution of dispersal, is critical for an informed assessment of species viability in the Anthropocene.
Clinical Importance of Superior Sensitivity of the Aptima TMA-Based Assays for Mycoplasma genitalium Detection

Mycoplasma genitalium (MG) is a common cause of nongonococcal cervicitis and urethritis. We investigated the demographic and clinical characteristics of patients tested in Denmark with the Conformité Européenne (CE)/in vitro diagnostics (IVD) Aptima Mycoplasma genitalium assay (CE/IVD AMG; Hologic) and examined the clinical significance of the higher sensitivity of the TMA-based MG assays. ABSTRACT Mycoplasma genitalium (MG) is a common cause of nongonococcal cervicitis and urethritis. We investigated the demographic and clinical characteristics of patients tested in Denmark with the Conformité Européenne (CE)/in vitro diagnostics (IVD) Aptima Mycoplasma genitalium assay (CE/IVD AMG; Hologic) and examined the clinical significance of the higher sensitivity of the TMA-based MG assays. From March to June 2016, urogenital and extragenital specimens from consecutive attendees at a sexually transmitted infection clinic in Copenhagen, Denmark were tested with the CE/IVD AMG assay (TMA-based), the research-use-only MG Alt TMA-1 assay (Hologic), a laboratory-developed TaqMan mgpB quantitative real-time PCR (qPCR), and the Aptima Combo 2 (CT/NG; Hologic). Demographic characteristics and clinical symptoms were collected from the patient records. There were 1,245 patients included in the study. The MG prevalence among female subjects was 9.4%, and the MG prevalence among male subjects was 8.7%. Compared to the TMA-based assays, the sensitivity of the PCR-based MG assay was 64.52%, and 55 specimens from 48 individuals were missed in the mgpB qPCR. Of these, 26 individuals (54.2%) were symptomatic, whereas, among 64 individuals with concordant results, 30 individuals (46.9%) were symptomatic; no statistically significant difference was found between the groups (P = 0.567). The improved sensitivity of the TMA-based assays resulted in diagnoses of more patients with clinically relevant symptoms for which antibiotic treatment is indicated. However, approximately half of the MG-infected patients reported no symptoms, and future research is needed to investigate the pros and cons of diagnosing and treating MG in asymptomatic subjects.
Galliformes exhibit reduced cardiorespiratory morphology yet similar skeletal mass compared with other gamebirds

ABSTRACT Flight is one of the most effective yet energetically demanding means of movement. Its energy costs are normally associated with interspecific variation in efficiency, size of organs, and physiological systems that reflect different flight capacities. Adaptive morphological variation may be constrained by physical demands that vary with body size, but work remains to place allometry associated with flight mode in an ecological and evolutionary context. We predicted that heart, lung, and skeletal masses, as well as tracheal diameter, should show a reciprocal positive correlation and have reduced size in species with poor flight capacities. We measured tracheal diameter together with lung, heart, and skeletal mass in 21 species of medium to large body sized game birds. We then compared 7 of these species categorized as short flyers belonging to the order Galliformes with 14 other species capable of sustained flapping flight. Our comparative analyses incorporating phylogeny revealed that once accounting for body mass, Galliformes had smaller heart mass compared to other species, as shown in few previous studies. Additionally, we detected reduced tracheal diameter and lung mass in Galliformes, suggesting the presence of morphological pleiotropy predicted under the concept of symmorphosis. These organs all showed different levels of reciprocal correlations due to their functional connection. Residual skeletal mass was independent of flight capacity and showed no relationship with heart mass, thus indicating that selection for reduced skeletal mass may have already maximized how light a bird skeleton can be, constraining mass-independent variation in this trait. Our results suggest that cardiorespiratory organs have evolved symmorphic variation in size that reflects costs and benefits associated with different flight capacities. However, our observed differences are confounded with phylogenetic history, so additional comparative studies are needed to rigorously test this hypothesis.
Ecological correlates to habitat use in the Cactus Wren (Campylorhynchus brunneicapillus)

ABSTRACT Conversion of natural habitats to urban landscapes is happening at a rapid pace around the globe. Establishing a preserve system and restoring lands within these preserves is one way to offset the loss of natural habitats. However, often when preserves are being developed little data exists outlining the distribution of species and the habitat parameters on which they depend. We used populations of the Cactus Wren (Campylorhynchus brunneicapillus sandiegensis) inhabiting the coastal slope of California to demonstrate how to refine the general gestalt of habitat conditions for the wren into defined parameters that can be used to develop strategic restoration plans. We found that wren habitat use declined to nearly 0% when cactus patches were spaced farther than 800 m apart, regardless of size. The probability of occupancy, or habitat use, rose above 60% when cactus patches were 0.15 ha in size or greater. Elderberry is an important factor in areas with little topographic relief, as it provides perching sites. Buckwheat may not be important to the wren but could be used to select sites that have drier conditions conducive to cacti. Planting cactus to restore ruderal sites properly selected for xeric conditions, and within relatively close proximity to each other, could help meet conservation goals of connecting and increasing wren populations by establishing ecological functions at a landscape level.
Examination of the Relationship Among Balance, Physical Activity, and Anthropometry in Athletes With Visual Impairments

Introduction Although it is well documented in the literature that individuals with visual impairments have low physical activity levels and impaired body compositions and postural controls compared with peers without vision loss, the relation between these parameters in athletes with visual impairments is unknown. Research Question Here, we (i) evaluated the physical activity levels, balance measures, and anthropometry parameters in athletes with visual impairments and peers without vision loss controls and (ii) compared these variables between the two groups. Methods We designed a retrospective observational study with parallel groups conducted on 33 athletes with visual impairments and 33 sighted controls matched for age and sex. We also utilized a questionnaire about physical activity levels and assessed static balance for 4 conditions (eyes-open firm surface, eyes-closed firm surface, eyes-open foam surface, and eyes-closed foam surface) and anthropometry. Results In athletes with visual impairments, body composition, body mass index (BMI), physical activity level, and static balance parameters revealed no significant relationship (p > .05), whereas eyes-open and -closed firm and foam surface conditions were positively related with physical activity at a moderate level (r = 0.39, r = 0.38, p < .05, respectively). Moderate-intensity and high-intensity physical activity was positively associated with fat-free mass (r = 0.82, r = 0.68, p < .01, respectively) and negatively related with body mass, fat %, and fat mass (r = −0.67, r = −0.52, r = −0.72, r = −0.66, r = −0.50, r = −0.50, p < .01, respectively). Athletes with visual impairments presented lower static balance than the sighted controls for three conditions, while eyes-closed foam surface scores were similar in both groups. The physical activity levels were higher for athletes with visual impairments (p < .05). However, we found no difference in the body composition and BMI between two groups (p > .05). Discussion Sports participation from individuals with visual impairments is related to higher physical activity levels, resulting in better anthropometric profile. The balance control was not related to physical activity levels in athletes with visual impairments.
A Review on Source Code Documentation

Context: Coding is an incremental activity where a developer may need to understand a code before making suitable changes in the code. Code documentation is considered one of the best practices in software development but requires significant efforts from developers. Recent advances in natural language processing and machine learning have provided enough motivation to devise automated approaches for source code documentation at multiple levels. Objective: The review aims to study current code documentation practices and analyze the existing literature to provide a perspective on their preparedness to address the stated problem and the challenges that lie ahead. Methodology: We provide a detailed account of the literature in the area of automated source code documentation at different levels and critically analyze the effectiveness of the proposed approaches. This also allows us to infer gaps and challenges to address the problem at different levels. Findings: (1) The research community focused on method-level summarization. (2) Deep learning has dominated the past five years of this research field. (3) Researchers are regularly proposing bigger corpora for source code documentation. (4) Java and Python are the widely used programming languages as corpus. (5) Bilingual Evaluation Understudy is the most favored evaluation metric for the research persons.
Characterizing surface-gap effects on boundary-layer transition dominated by Tollmien–Schlichting instability

Abstract Effects of gaps (rectangular surface cavities) on boundary-layer transition are investigated using a combination of linear stability theory and experiments, for boundary layers where the smooth-surface transition results from Tollmien–Schlichting (TS) instability. Results are presented for a wide range of gap characteristics, with the associated transition locations ranging from the smooth-surface location all the way forward to the gap location. The transition movement is well described by a variable $N$-factor, which links the gap characteristics to the level of instability amplification $e^N$ leading to transition. The gap effects on TS-wave transition are characterized by two limiting behaviours. For shallow gaps $d/w < 0.017$, the reduction in $N$-factor is a function of the gap depth $d$ and is independent of the gap width $w$. For deep gaps $d/w > 0.028$, the reduction in $N$-factor is a function of the gap width and is independent of the gap depth. When both the gap width and depth are sufficiently large relative to the displacement thickness $\delta ^*$, the TS-wave transition is bypassed, resulting in transition at the gap location. These behaviours are mapped out in terms of ($w/ \delta ^*$, $d/ \delta ^*$), providing a predictive model for gap effects on transition.
Adolescents’ motivation for family travels: cross-culture/cross-country evidence

ABSTRACT This study used a measurement model to investigate adolescents in 25 countries, in an effort to understand their motivations for attending family travel. In general, both cultural region and culture type were related to travel motivation patterns and studentized residual patterns. In addition, overall, a country’s level of development and its cultural dimensions were more strongly correlated with females’ travel motivations of interpersonal escape and seeking than with those motivations in males. We also confirmed a U-shaped relationship of cultural response bias in certain measures of motivation components in connection with three indicators: masculinity, uncertainty avoidance, and family score.