Miracle-dz/UniFAR-FTUs huggingface dataset:
Macrolide Allergy in Children and the Negative Predictive Value of Drug Provocation Tests in Mild Index Reactions

ABSTRACT Objective: Macrolide allergy is rarely reported, and there is limited knowledge of hypersensitivity reactions (HRs) in children. The negative predictive value (NPV) of drug provocation tests (DPTs) for macrolides is unresolved. We aim to evaluate the clinical features of macrolide allergy in children, and determine the NPV of macrolide DPTs. Materials and Methods: Pediatric patients who were referred to our allergy department with a suspicion of macrolide allergy were evaluated by DPTs with or without prior skin tests between 2011 and 2020. Characteristics of the HRs and patients, the results of skin and DPTs were recorded. At least three months after evaluation of the patients with allergy work up, telephone interviews were performed. Patients were asked whether they had reused the suspected macrolide or not. Patients who reported HR during subsequent drug intake were invited for reevaluation. Results: A total of 160 children (161 reactions) (55.6% male) with a suspicion of macrolide allergy were enrolled for the study, and all children had a mild index reaction. The median age was 48 (18-102) months, and the median time between the suspected allergic reaction and allergy work-up was 3 (2-8) months. The most frequently reported suspected agent was clarithromycin, in 151 patients (94.4%). Macrolide allergy was confirmed in 8 (5%) patients. Only one patient reported skin eruptions upon reuse despite a negative DPT and he was invited to be reevaluated. A second DPT was performed resulting in urticarial lesions. The NPV was found to be 97.4% for negative DPT with macrolides. Conclusion: Confirmed macrolide allergy is rare in children, and DPTs are the gold standard to assess suspected macrolide allergy. The NPV of macrolide provocation tests seems to be high in children. Keywords: Children, drug hypersensitivity, drug provocation test, macrolide, negative predictive value
Improving Nurses' Performance in Safe Handling of Antineoplastic Agents: a Quasi-experimental Study

Background: The safe, principled, and standard handling of anticancer drugs can reduce the effects of occupational exposure and promote safe behaviors in nurses. Thus, the present study aimed to determine the effects of standard guidelines education on the safe handling of anti-neoplasm drugs among oncology nurses in Ardabil, Iran.Methods: The quasi-experimental study with one-group pretest-posttest design was performed among 32 nurses employed in the oncology wards of two educational hospitals in Ardabil city, during 2020. All of the nurses in the wards who met the inclusion criteria participated in the study. The data were collected by using a demographic information form and nurses' knowledge assessment questionnaire regarding the standard guidelines for working with antineoplastic drugs, and a standard checklist for examining their performance in this regard. Then, they were analyzed through descriptive (mean and standard deviation) and inferential statistics (t-test and Pearson's correlation coefficient) in SPSS 22.Results: The mean and standard deviation of the knowledge and performance scores of the oncology nurses was respectively determined 59.56±6.41 and 18.96±2.54, which changed to 66±4.82 and 32.03±2.45 three months after training. The results of t-test represented a statistically significant difference between the level of knowledge and performance before and after the intervention (P=0.001). Conclusions: Based on the results, the standard guidelines education improved the nurses' knowledge and performance on the safe handling of anticancer drugs in the chemotherapy wards. Therefore, it is suggested to pay attention to the promotion of the oncology nurses' awareness in the planning and policy-making of healthcare centers.
Hunter acceptability of chronic wasting disease (CWD) management actions in Western Tennessee

ABSTRACT Chronic Wasting Disease (CWD), a neurological disease affecting white-tailed deer has been found in many states including Tennessee. To design effective CWD management programs, stakeholders including state wildlife agencies benefit from understanding hunters’ attitudes and acceptability of alternative management actions. By conducting a mixed-mode survey of hunters, we compared the risk perception and relative acceptability of management actions before and after the first deer hunting season since the discovery of CWD in Tennessee. Logistic regression models were used to evaluate factors affecting hunters’ acceptability of alternative management actions. Acceptability was significantly affected by concerns related to deer and human health, regulatory changes, trust and confidence on wildlife agency, and experience of hunting in other states with CWD. These results shed light on understanding hunter’s perception of risk, and roles of trust, perceived risk and hunters’ characteristics in CWD management.
Modeling Proportion Data with Inflation by Using a Power-Skew-Normal/Logit Mixture Model

Rate or proportion data are modeled by using a regression model. The considered regression model can be used for studying phenomena with a response on the (0, 1), [0, 1), (0, 1], or [0, 1] intervals. To connect the response variable with the linear predictor in the regression model, we use a logit link function, which guarantees that the obtained prediction ranges between zero and one in the cases inflated at zero or one (or both). The model is complemented with the assumption that the errors follow a power-skew-normal distribution, resulting in a very flexible model, and with a non-singular information matrix, constituting an advantage over other existing models in the literature. To explain the probability of point mass at the values zero and/or one (inflated part), we used a polytomic logistic model with covariates. The results of two illustrations showed that the proposed model is a better alternative compared to widely known models in the literature.
On Various High-Order Newton-Like Power Flow Methods for Well and Ill-Conditioned Cases

Recently, the high-order Newton-like methods have gained popularity for solving power flow problems due to their simplicity, versatility and, in some cases, efficiency. In this context, recent research studied the applicability of the 4th order Jarrat’s method as applied to power flow calculation (PFC). Despite the 4th order of convergence of this technique, it is not competitive with the conventional solvers due to its very high computational cost. This paper addresses this issue by proposing two efficient modifications of the 4th order Jarrat’s method, which present the fourth and sixth order of convergence. In addition, continuous versions of the new proposals and the 4th order Jarrat’s method extend their applicability to ill-conditioned cases. Extensive results in multiple realistic power networks serve to sow the performance of the developed solvers. Results obtained in both well and ill-conditioned cases are promising.
The Moderating Role of Corporate Governance on the Relationship between Tax Avoidance and Firm Value

This study aimed to examine the moderating role of corporate governance on the relationship between tax avoidance and firm value. In this study, the data sample used are manufacturinglisted in Indonesia Stock Exchange. Data collection method using purposive sampling and collected 188 samples from 2016-2019. The data was analyzed using multiple linier regression. Statistical result indicates that tax avoidance has a negative effect on firm value. While the corporate governance is not able to influence the relationship between tax avoidance and firm value. Tax avoidance will be more relates to accounting policy, while corporate governance in this study is in shed of non-accounting scope. Therefore, it cannot be the moderation between tax avoidance and firm value.Penelitian ini bertujuan untuk menguji peran moderasi tata kelola perusahaan terhadap hubungan antara penghindaran pajak dan nilai perusahaan. Dalam penelitian ini, sampel yang digunakan berupa perusahaan manufaktur yang terdaftar dalam Bursa Efek Indonesia. Pengumpulan data menggunakan metode purposive. Hasil seleksi sampel memperoleh 188 sampel dari tahun 2016-2019, selanjutnya data dianalisis menggunakan regresi linier berganda Hasil pengujian menunjukkan bahwa penghindaran pajak berpengaruh negatif terhadap nilai perusahaan. Di sisi lain, tata kelola perusahaan tidak mampu mempe-ngaruhi hubungan antara penghindaran pajak terhadap nilai perusahaan tersebut. Penghindaran pajak lebih berkaitan dengan kebijakan akuntansi, sedangkan tata kelola perusahaan justru berkaitan dengan lingkup non-akuntansi. Oleh karena itu, tata kelola perusahaan tidak dapat berperan sebagai moderasi antara penghindaran pajak dan nilai perusahaan
Association Analysis of Molecular Markers with Essential Agronomic Traits under Normal and Salt Stress in Wide Germplasm of Foxtail Millet (Setaria Italica L.)

Food security and nutrition concerns are putting an ancient, climate-smart grain back on our plates; Farm to fork, there has been a revival of interest in millet. Foxtail millet, as a multi-purpose product, has nutritious and medicinal potentials. This research is aimed at identifying combined markers as well as stable associations between such markers and the investigated agronomic traits in a wide range of foxtail millet germplasms under normal and salinity-stress conditions. In this context, association analysis has been conducted among 14 agronomic traits and 331 polymorphic AFLP markers generated by 12 primer combinations in 134 foxtail millet genotypes. Based on the analysis of population structure, the foxtail millet genotypes were divided into six subpopulations. The results showed that a number of markers had stable and significant associations under both normal and salinity-stress conditions with agronomic traits. The primer combinations had high polymorphic percentage, diversity indices were highly reliable and revealed significant genetic variability among the genotypes. Their PIC, MI and Shannon’s indices were also highly reliable and revealed significant genetic variability among the genotypes. Since the markers introduced in this research have stable and strong associations with the investigated traits under normal and salinity stress conditions, they can be suitable candidates’ in future marker-assisted breeding to improve salinity- resistance genotypes of foxtail millet in arid and semiarid areas.
Forty years of the rural tourism research: reviewing the trend, pattern and future agenda

Rural tourism has been a key research area over the last few decades. However, evaluating the advancement of its dimensions as a systematic and comprehensive audit was long overdue. This study performed a bibliometric analysis on 404 articles from 1980 to 2019 and revealed that rural tourism has maximum growth in the last two decades. Deductive and quantitative methods are the principally implemented theoretical and methodical approaches, respectively. The developed countries have majorly contributed from 1980 to 1999, while the last two decades the developing nations have contributed. The rural tourism research in the developed world has matured by debating critical issues such as community politics, power struggle, resource control, whereas these issues along with several new issues, such as climate change and epidemic, have ample scope in future especially in the context of Eastern World. This study o ﬀ ers an insight into the evolution of conceptual framework, authorship, institution-speci ﬁ c productivity, spatial distribution of study areas, crucial themes, and the future research directions. The present ﬁ ndings will work as a comprehensive reference to the potential research dimensions and add to the existing knowledge body of the tourism research in general and the rural tourism research in particular.
Bullying and Harassment as a Consequence of Workplace Change in the Australian Civil Service: Investigating the Mediating Role of Satisfaction With Change Management

Public sector organizations frequently restructure due to shifting management trends, crises, and political developments. Earlier research indicates that the sometimes-drastic reforms implemented in government strongly affect employees, causing psychosocial effects such as frustration, stress, and negative work environments. This may in turn increase the likelihood of severe phenomena such as workplace bullying and harassment. It remains unclear, however, how public organizations can introduce changes while preventing side-effects such as bullying and harassment. The goal of this article is twofold. First, we test whether evidence on the relationship between workplace change and bullying and harassment holds when using a large, public sector-wide sample. Second, we investigate whether satisfaction with change management plays a mediating role. Using cross-sectional and strata-based panel data analyses on Australian data, results indicate a positive relationship between workplace change and workplace bullying and harassment, but also suggest that satisfaction with change management mitigates this effect.
Temporary Contracts, Employment Trajectories and Dualisation: A Comparison of Norway and Sweden

This study compares the labour market trajectories of the temporary employed in Norway with those in Sweden. Sweden’s employment protection legislation gap between the strict protection of permanent employment and the loose regulation of temporary employment has widened in recent decades, while Norway has maintained balanced and strict regulation of both employment types. The study asserts that the two countries differ concerning the distribution of trajectories, leading to permanent employment and trajectories that do not create firmer labour market attachment. Using sequence analysis to analyse two-year panels of the labour force survey for 1997–2011, several different trajectories are discerned in the two countries. The bridge trajectories dominate in Norway, while dead-end trajectories are more common in Sweden. Moreover, the bridge trajectories are selected to stronger categories (mid-aged and higher educated) in Sweden than in Norway. The results are discussed from the perspective of labour market dualisation.
Office Indoor PM and BC Level in Lithuania: The Role of a Long-Range Smoke Transport Event

While the impacts of climate change on wildfires and resulting air pollution levels have been observed, little is known about how indoor air filtering systems are performing under intensive smoke conditions. For this aim, particle number size distribution and concentration in a size range 0.5–18 µm and equivalent black carbon (eBC) mass concentration were measured in a modern office with a mechanical ventilation system. Measurements took place from 30 September to 6 October 2020 in the Center for Physical Sciences and Technology (FTMC) campus located in the urban background environment in Lithuania. During the measurement campaign, an intensive pollution episode, related to long-range transport wildfire smoke, was observed. The results indicated that the smoke event increased both indoor and outdoor eBC mass concentrations twice. Filters were non-selective for different eBC sources (biomass burning versus traffic) or chemical composition of carbonaceous aerosol particles (eBC versus brown carbon (BrC)). Air filtering efficiency was found to be highly dependent on particle size. During the smoke event the highest particle number concentration was observed at 2.1 µm and 1.0 µm size particles in outdoor and indoor air, respectively. Differences of indoor to outdoor ratio between event and non-event days were not significant. Because of lower removal rate for small particles, eBC had higher contribution to total PM2.5 mass concentration in indoor air than in outdoor air. The results gained are crucial for decision-making bodies in order to implement higher-quality air-filtering systems in office buildings and, as a result, minimize potential health impacts.
Creativity-driven urban regeneration in the post-socialist context - The case of Csepel Works, Budapest

ABSTRACT The complex institutional, economic, and societal trends that have characterized the post-socialist transition in Central and Eastern European countries have drastically reshaped urban development. The case of Budapest shows that three decades of nearly exclusive market-driven urban policies have resulted in a variety of social, spatial and environmental deficiencies. This paper presents the paradigm of creativity-driven urban regeneration and proposes an approach to implement this paradigm, with a key role for urban design interventions, to successfully address these challenges, specifically, the regeneration of industrial brownfields, in an integrated manner and to create more inclusive, just, and sustainable cities.
Quantifying self-quantification: A statistical study on individual characteristics and motivations for digital self-tracking in young- and middle-aged adults in Germany

This study presents a quantitative account of who uses or stops using digital self-tracking (ST). A representative sample of German adults aged 20–50 years (N = 1022) completed an online survey on their ST practices, personality traits and attitudes toward numbers, on sociodemographic characteristics, mental disorders (particularly bulimia, burnout syndrome, and depression) and somatic disorders. A descriptive statistical analysis was performed on differences between self-trackers and non-trackers. Among others, they differ regarding age, civil status, social class, presence of mental and/or somatic diagnoses, performance-pressure, and strive for competition. A consequent binary logistic regression analysis suggests perfectionism, a somatic diagnosis within the last 5 years, a diagnosis of bulimia in the past, as well as a present mental diagnosis to be significant predictors for ST, though the predictive value of the factors was relatively low.
Tracing the origin of the South Asian summer monsoon precipitation and its variability using a novel Lagrangian framework

The water sources and their variability responsible for the South Asian summer monsoon precipitation were analyzed using Lagrangian atmospheric water-mass trajectories. The results indicated that evaporated waters from the Central and South Indian Ocean are the major contributors to the South Asian summer monsoon rainfall, followed by the contribution from the local recycling (precipitated water that evapotranspirated from the South Asian landmass), the Arabian Sea, remote sources and the Bay of Bengal. It was also found that although the direct contribution originating from the Bay of Bengal is small, it still provides a pathway for the atmospheric water that come from other regions. This pathway is hence only crossing over the Bay of Bengal. The outcomes further revealed that the evaporated waters originating from the Central and South Indian Ocean are responsible for the net precipitation over the coastal regions of the Ganges-Brahmaputra-Meghna Delta, Northeast India, Myanmar, the foothills of the Himalayas and Central-East India. Evaporated waters from the Arabian sea are mainly contributing to the rainfall over the Western coast and West-Central India. Summer monsoon precipitation due to the local recycling is primarily restricted to the Indo-Gangetic plain. No recycled precipitation was observed over the mountain chain along the West coast of India (Western Ghats). The month-to-month precipitation variation over South Asia was analysed to be linked with the Somali Low Level jet variability. The inter-annual variability of the South Asian summer monsoon precipitation was found to be mainly controlled by the atmospheric waters that were sourced and travelled from the Central and South Indian Ocean.
High density genetic mapping of stripe rust resistance in a ‘Strongfield’ / ‘Blackbird’ durum wheat population

Abstract Resistance breeding is an effective strategy against wheat stripe (yellow) rust caused by Puccinia striiformis f. sp. tritici (Pst). To identify and map quantitative trait loci (QTL) associated with stripe rust resistance, a durum wheat doubled haploid population (n = 87) derived from ‘Strongfield/Blackbird’ was evaluated for disease severity near Toluca, Mexico (2017–2019) and Lethbridge, Canada (2016–2019). The population was genotyped with the wheat 90 K Illumina iSelect single nucleotide polymorphism (SNP) array and simple sequence repeat (SSR) markers, and QTL analysis was performed with MapQTL 6. We identified stripe rust-resistance QTL contributed by ‘Blackbird’ on chromosomes 3A (2 loci, designated QYr.spa-3A.1, QYr.spa-3A.2) and 5B (QYr.spa-5B), and ‘Strongfield’ on 2B (QYr.spa-2B). All seem to represent QTL not reported previously. The QYr.spa-3A.2 was most consistently effective against Pst races across the Lethbridge and Toluca nurseries. With a LOD value of 4.9, QYr.spa-3A.2 explained a maximum phenotypic variation of 22.7% observed at the Toluca 2019 nursery. The QYr.spa-2B from ‘Strongfield’ and QYr.spa-3A.1 from ‘Blackbird’ expressed in multiple years at Toluca but were not detected at Lethbridge. QYr.spa-5B was identified in the Lethbridge 2016 environment. The identified QTL should be valuable in diversifying resistance genes used in breeding durum wheat cultivars with stripe rust resistance. ‘Blackbird’ was particularly useful for introducing the new QTL QYr.spa-3A.2 resistance that is effective in Canada and Mexico into traditional durum wheat germplasm. SNP markers associated with QTL will have application in marker-assisted breeding of resistance to Pst in durum wheat.
Simulation-Based Operational Evaluation of a Single-Berth Multipurpose Seaport with Wharf Space Restriction

Overcapacity of seaport infrastructure has been a common issue in many countries in recent years. Cautious investment decisions shall be made on the basis of realistic capacity evaluation and productivity improvement of existing ports. However, operational analysis and evaluation of a seaport is not always easy, especially for multipurpose terminals which are commonly seen in developing countries. These small-scaled multipurpose seaports handle different cargo types with multiple interrelated processes and varying handling methods and process times. This paper studies a single-berth multipurpose seaport with wharf space restriction in Indonesia and shows how the simulation model can be essential and significantly helpful in the evaluation of the port’s productivity and realistic capacity. Furthermore, a new handling method is proposed and evaluated by the simulation model. The simulation approach and related results help the port operator in making decisions regarding port improvement and future expansion investments.