Miracle-dz/UniFAR-FTUs huggingface dataset:
The Relationship Between Magnetic Resonance Imaging and Electrodiagnostic Studies in Patients with Ulnar Neuropathy at the Elbow

Objective: This study investigated the correlations between magnetic resonance imaging (MRI) and nerve conduction studies (NCS) in patients with ulnar neuropathy at the elbow (UNE). Methods:In total, 46 patients who underwent elbow MRI and NCS at a single center from 2014 to 2018 were included. Motor studies, including segmental and inching tests, and sensory NCS were performed. The 5-point severity score was evaluated based on the signal change and swelling in the fat-suppressed T2 weighted sequence. The findings of MRI and NCS were grouped into 3 categories. The Spearman rank test was used to evaluate correlations between the severity score on MRI and electrodiagnostic parameters.Results:The locations of the lesions on MRI and NCS were correlated in 20 of the 46 patients with UNE, while the other 20 patients had no correlations. Six patients who could not be categorized according to the location showed various findings. The severity score based on MRI showed significant negative correlations with amplitude on the segmental study (r = -0.423, p = 0.002) and the inching study (r = -0.456, p = 0.002), and with conduction velocity in the segmental study (r = -0.526, p < 0.001) and the inching study (r = -0.548, p < 0.001). Conclusion Electrodiagnostic outcomes had negative correlations with the severity score, reflecting the structural changes seen on MRI. Combining electrodiagnostic studies and MRI could make the diagnosis and localization more precise.
The clinical profile of patients attending a large, Australian pediatric gender service: A 10-year review.

Objectives: To better understand the clinical profile of patients attending a large Australian pediatric gender service. Retrospective clinical audit of patients seen at the Royal Children's Hospital Gender Service (RCHGS) over 10 years (2007-16). Setting: The RCHGS: Australia's largest pediatric gender service. Participants: Patients were eligible for inclusion if they had an appointment with the RCHGS between January 2007 - December 2016, and had either a self-reported gender which differed from what was presumed for them at birth or sought guidance regarding gender identity/expression. Main outcome measures: Demographic/developmental history, clinical presentation including information about gender identity/dysphoria, comorbidities, self-harm, suicidal ideation, gender-affirming treatment, psychosocial functioning. Results: 359 patients were first seen during the study period. Assigned females (54%) slightly outnumbered assigned males (46%), and presented at an older age (14.8 vs 12.4 years. Patients predominantly identified as transgender (87.2%) or non-binary (7.2%). Across the cohort, gender diversity was evident from a young age (median age 3), and symptoms of gender dysphoria were noted earlier in assigned males (median age 4) than assigned females (median age 11). Although 81% of patients met eligibility for GD, rates of hormonal treatment were much lower, with 29% of young people ≥10 years of age receiving puberty blocking treatment and 38% of adolescents ≥ 16 years of age receiving gender-affirming hormones (i.e. testosterone or estrogen). Many patients had mental health difficulties and/or neurodevelopment disorders, including major depressive disorder/low mood (51%), self-harm (25%), suicidal ideation (30%) and autism spectrum disorder (16%). Conclusion: This audit illustrates the complex profile and needs of transgender and gender diverse children and adolescents presenting to specialist gender services. Supplemental data for this article is available online at https://doi.org/10.1080/26895269.2021. 1939221 .
Prevalence of Work-Related Health Hazard and Associated Factors among Health Workers in Public Health Institutions of Gambella Town, Western Ethiopia: Cross-Sectional Survey

Background Many health-related occupational hazards confront healthcare workers. Examining the prevalence of hazards enables to search for better risk management for healthcare workers because these workers are often the first point of interaction, particularly in resource-limited settings like Ethiopia. Therefore, this study assessed the prevalence of work-related occupational hazards and identified related factors among healthcare workers in public health facilities of Gambella town, Western Ethiopia. Methods Institution-based cross-sectional study was conducted among 260 randomly selected healthcare workers from June 1-21, 2021. A semi structured tool was used to collect data and data analysis was performed using SPSS version 25. Multivariable logistic regression was used to identify the predictors of outcome variable and the significance of associations was declared by using a 95% CI and a p-value of <0.05. Results The prevalence of occupational health hazards among healthcare workers was 36.5% (95% CI: 31, 42). The absence of immediate treatments for injured health workers (AOR = 8.86, 95% CI: 2.5, 31.4), lack of personal protective equipment (AOR = 3.6, 95% CI: 1.5, 8.4), working greater than eight hours per day (AOR = 7.9, 95% CI: 3.1, 19.7), working in the night shifts (AOR = 8.1, 95% CI: 2.5, 26.1), and absence of effective leadership in the health facility (AOR = 5.2, 95% CI: 1.9, 14.5) were factors associated with the prevalence of occupational hazards. Conclusions There was a relatively high degree of occupational health hazard exposure among health workers in the study area compared to kinds of literature from other settings. Health workers were exposed to a wide range of occupational hazards, and risk reduction mechanisms and safety actions were inadequately implemented. Therefore, the health workers' occupational health and safety needs should be prioritized and appropriate measures should be taken to mitigate the problems.
WSRT observations of core-dominated radio sources

A few years ago we presented evidence for large scale radio structures around most superluminal radio sources (Schilizzi and de Bruyn, 1983)· The extended emission is relatively faint and, in at least two cases (3C120 and 3C345), exhibits a rather complex morphology. Although the sample was small, the conclusion seemed inescapable that the largest angular sizes (LAS) of the superluminals do not permit a large deprojection factor due to foreshortening, without making these sources exceptionally large intrinsically. That is to say, they would be exceptional within the context of the unified scheme (US) which interprets superluminal sources as favourably oriented, strongly beamed, core components of classical double radio sources. To save the US, we concluded that the ejection axes of these sources must undergo a large (i 30°) change of direction in the period between the creation of the outer and inner emission regions. Superluminality would then be a temporary phase (although possibly recurrent) in the lifespan of a large fraction of the parent population of classical doubles. In order to extend this result to a larger sample of objects we made observations with the WSRT of 14 sources generally thought to be akin to the superluminal sources. In this sample we included a variety of objects: low frequency variables, optically violent variables and BLLac type objects. The selection criteria for the sample were loosely defined: we chose strongly core-dominated radio sources with a flux density of at least 2 Jy at 6 cm and at accessible declinations (6^15°) in order to also obtain good resolution in the declination direction (the WSRT is an EW-interferometric array). The sources in the sample were: 0133+47(0C457), 0235+164, 0552+39(DA193), 0735+178, 0836+71, 0851+20(0J287), 0954+55(4C55.17), 1219+28(W Coma), 1308+32, 1358+62, 1611+34(DA406), 2201+42(BL Lac), 2230+11(CTA102), 2251+16(30454.3).
An exploration of mental distress in transgender people in Ireland with reference to minority stress and dissonance theory

Abstract Introduction: Internationally mental distress is more prominent in the LGBTI community than the general population. The LGBTIreland study was set up to take stock of this in the Republic of Ireland. This paper reports on the analysis of the transgender group with reference to minority stress theory and cognitive dissonance theory. Method: An online survey was conducted addressing several aspects of mental health and distress that received responses from all groupings (n = 2,264) among which 12.3% (n = 279) identified as transgender. The survey consisted of several validated tools to measure depression, anxiety, stress (DASS-21), coping (CSES), self-esteem (RSES), alcohol and drugs misuse (AUDIT) and a variety of questions addressing demographics, experiential aspects, coping and self-related factors. Data analysis focused on predicting mental distress using DASS-general (composite of depression, anxiety and stress). Results: Transgender participants reported higher levels of mental distress, self-harm, suicidal ideation and attempts, and lower levels of self-esteem in comparison with the LGB groups, as well as the general population. Hierarchical multiple regression showed that 53% of variance in mental distress could be predicted from reduced self-esteem, the experience of harassment and not belonging in school. Furthermore, mental distress was highest among younger participants, those who were ‘not out’, those who had self-harmed and used avoidant coping. There was no significant difference in distress levels among those who had sought mental health support and those who had not. Conclusions: To understand mental distress in transgender people, the minority stress model is useful when taking into account both adverse external (environmental) and internal (cognitive/emotional) factors. The cognitive dissonance mechanism is essential in outlining the mechanism whereby gender incongruence is associated with psychological discomfort, low self-esteem and high mental distress.
Racial Disparities in Prostate Cancer Stage at Diagnosis Persist Despite Community Affluence

Purpose The aims of this investigation were to evaluate racial disparities in prostate cancer among men living in a relatively affluent community with access to high quality healthcare. Patients and Methods This retrospective study included 1363 cases with prostate cancer entered into the Stony Brook Cancer Center registry between 2010 and 2020. Demographic and other factors, including the Distressed Community Index (DCI) which provides an indicator of socioeconomic status by zip code, were analyzed as predictors of later stage disease using logistic regression. Results Approximately 60% of cases resided in a “prosperous” zip code (DCI<20) with median (range) DCI of 16.3 (1.1, 61.8). Black men were diagnosed with later stage disease at a higher rate (p=0.03) and were more likely to be diagnosed at a younger age (p<0.01) compared to White men. However, the distribution of cancer stage stratified by DCI and race did not differ among groups. Black men were 3 times more likely to have Medicaid and a history of diabetes, as well as 33% more likely to have hypertension than White men. Black race (OR=2.08, (1.26, 3.42)), older age (OR=2.56 (1.67, 3.90)) and current smoking (OR=1.61 (1.07, 2.42)) were significant contributors of later stage cancer. Conclusion Black men residing in a relatively affluent suburb were diagnosed at younger ages, later stages, and were more likely to have additional comorbidities compared to White men. This study highlights the complexity of the environmental, societal, and biological contributors to racial disparities that warrants further investigation into the underlying causes for the excess burden on Black men.
Unveiling Natural and Semisynthetic Acylated Flavonoids: Chemistry and Biological Actions in the Context of Molecular Docking

Acylated flavonoids are widely distributed natural metabolites in medicinal plants and foods with several health attributes. A large diversity of chemical structures of acylated flavonoids with interesting biological effects was reported from several plant species. Of these, 123 compounds with potential antimicrobial, antiparasitic, anti-inflammatory, anti-nociceptive, analgesic, and anti-complementary effects were selected from several databases including SCI-Finder, Scopus, Google Scholar, Science Direct, PubMed, and others. Some selected reported biologically active flavonoids were docked in the active binding sites of some natural enzymes, namely acetylcholinesterase, butyrylcholinesterase, α-amylase, α-glucosidase, aldose reductase, and HIV integrase, in an attempt to underline the key interactions that might be responsible for their biological activities.
Permafrost Landscape History Shapes Fluvial Chemistry, Ecosystem Carbon Balance, and Potential Trajectories of Future Change

Intensifying permafrost thaw alters carbon cycling by mobilizing large amounts of terrestrial substrate into aquatic ecosystems. Yet, few studies have measured aquatic carbon fluxes and constrained drivers of ecosystem carbon balance across heterogeneous Arctic landscapes. Here, we characterized hydrochemical and landscape controls on fluvial carbon cycling, quantified fluvial carbon fluxes, and estimated fluvial contributions to ecosystem carbon balance across 33 watersheds in four ecoregions in the continuous permafrost zone of the western Canadian Arctic: unglaciated uplands, ice‐rich moraine, and organic‐rich lowlands and till plains. Major ions, stable isotopes, and carbon speciation and fluxes revealed patterns in carbon cycling across ecoregions defined by terrain relief and accumulation of organics. In previously unglaciated mountainous watersheds, bicarbonate dominated carbon export (70% of total) due to chemical weathering of bedrock. In lowland watersheds, where soil organic carbon stores were largest, lateral transport of dissolved organic carbon (50%) and efflux of biotic CO2 (25%) dominated. In watersheds affected by thaw‐induced mass wasting, erosion of ice‐rich tills enhanced chemical weathering and increased particulate carbon fluxes by two orders of magnitude. From an ecosystem carbon balance perspective, fluvial carbon export in watersheds not affected by thaw‐induced wasting was, on average, equivalent to 6%–16% of estimated net ecosystem exchange (NEE). In watersheds affected by thaw‐induced wasting, fluvial carbon export approached 60% of NEE. Because future intensification of thermokarst activity will amplify fluvial carbon export, determining the fate of carbon across diverse northern landscapes is a priority for constraining trajectories of permafrost region ecosystem carbon balance.
Thinking about what he thinks of what I think: Assessing higher theory of mind abilities in Indian bilingual children between 3.0 and 8.11 years of age

Context: The competence in theory of mind (ToM) abilities occurs in parallel with the development of language. To gain a deeper discernment about its proficiency, tasks tapping on higher-order ToM abilities have been implemented. Aims: This study aims to explore the development of higher-order ToM abilities in bilingual Indian children between 3.0 and 8.11 years of age, to achieve an insight into the influence of language on ToM abilities. Settings and Design: The current study followed a cross-sectional design along with an employment of a random convenient sampling procedure. The study was conducted in regular English medium schools with each participant individually being assessed. Materials and Methods: The study was done on 60 Kannada-English bilingual children, with each participant being assessed using two sets of stories (English and Kannada) that were constructed based on two different central themes which were verbally narrated. The stimulus of each set consisted of questions tapping on three levels (first-second-third orders) of ToM abilities. Statistical Analysis: Descriptive statistics determined the mean and standard deviation of the total ToM scores (in both languages). Wilcoxon Signed-Rank and Mann–Whitney U-tests were done to determine the level of significance across and between the age groups (in both languages), respectively. Results: The results revealed a significant difference across the age groups. In addition, a significant difference between the responses in English and Kannada were obtained. Conclusions: The development of metalinguistic abilities is influenced by socioenvironmental factors as well as the language maturity of the child.
Relationships among Traditional Gender Roles, Acceptance of External Influence and Self-Alienation: The Mediator Role of Internalized Sexism

This study dealt with the relationships among the frequency of messages about traditional gender roles that women receive throughout their growing up processes, their acceptance of external influence and their self-alienation. In addition, it was examined whether the relationship between traditional gender roles and acceptance of external influence, and the relationship between traditional gender roles and self-alienation, are established through internalized sexism. The participants of the study were 443 women studying at the undergraduate level at various universities of Turkey. For the study, the Traditional Gender Roles Subscale of the Socialization of Gender Norms Scale, the Internalized Sexism Scale and the Authenticity Scale's dimensions of Acceptance of External Influence and Self-Alienation were used. The results revealed the full mediating role of internalized sexism in the relationship between the frequency of traditional gender role messages and acceptance of external influence and self-alienation. The results were discussed and interpreted within the framework of the relevant literature, and suggestions were presented for future studies.
Evaluation of Accuracy and Feasibility of a New-Generation Ultra-Rapid Urease Test for Detection of Helicobacter pylori Infection

Helicobacter pylori (Hp) infection can be diagnosed by invasive and noninvasive methods, and, among the former, Rapid Urease Tests (RUTs) are an important option. Accuracy and rapidity of results are fundamental for RUTs. The aim of the study is to prospectively evaluate the sensitivity, specificity and time to positivity of a new-generation ultra-rapid urease test (iNatal duo test) for Hp detection and compare the results with other available RUTs [CLO Test (Campylobacter-Like Organism Test), CP Test (Campylobacter pylori Test) and Pronto Dry]. Gastric biopsies were taken in consecutive patients undergoing upper endoscopy: two in the antrum and two in the body for histology, and one in the antrum and one in the body for each RUT. RUTs were read at 1, 5, 15, 30 and 60 min, 3 h and 24 h after biopsy insertion into the reagent. Histology was considered as “gold standard”. The performance of the tests was evaluated in patients not taking proton pump inhibitors (PPI) (n = 924) by calculation of sensitivity, specificity and positive and negative predictive value. Agreement rate (κ) for every RUT and histology was calculated and compared. The performance of the iNatal duo test was also tested in a subgroup of patients taking PPI (n = 198). Hp was positive in 225/924 patients (24.3%) not taking PPIs and in 56/198 (28.3%) who were taking PPIs. The iNatal duo test was more sensitive than the other RUTs for detecting Hp at every time point. The sensitivity at 5 min was 96.2% in patients not taking PPIs and 92.2% in patients taking PPIs. κ with histology was higher for the iNatal duo test than any other RUT (at 30 min: iNatal duo 0.99, CLO 0.60, CP 0.78, Pronto 0.85, at 15 min: iNatal duo 0.99, CLO 0.46, CP 0.63, Pronto 0.71). In a prospective study, the iNatal duo test demonstrated high accuracy and rapidity for Hp detection, both in patients with and without PPI therapy. This new generation of ultra-rapid urease test could be useful for the rapid and correct management of patients undergoing upper GI endoscopy for suspected Hp infection.
Biorefinery Approach Applied to the Production of Food Colourants and Biostimulants from Oscillatoria sp.

Simple Summary In this study, a biorefinery based on Oscillatoria sp. is developed to produce high-value compounds such as C-phycocyanin, used in food colourant applications, and biostimulants, used in agriculture-related applications. The results confirm that C-phycocyanin concentrations ranging from 22 to 106 mg/L produce colours similar to commercial products; moreover, the safety of the extracted C-phycocyanin was confirmed through toxicity tests. The leftover biomass was confirmed as a biostimulant, with the results confirming a relevant auxin-like positive effect. Finally, an economic analysis was conducted to evaluate different scenarios, with results confirming this as the best scenario from an economic standpoint. Abstract In this study, a biorefinery based on Oscillatoria sp. is developed to produce high-value compounds such as C-phycocyanin, used in food colourant applications, and biostimulants, used in agriculture-related applications. First, the Oscillatoria biomass production was optimized at a pilot scale in an open raceway reactor, with biomass productivities equivalent to 52 t/ha·year being achieved using regular fertilizers as the nutrient source. The biomass produced contained 0.5% C-phycocyanins, 95% of which were obtained after freeze–thawing and extraction at pH 6.5 and ionic strength (FI) 100 mM, with a purity ratio of 0.71 achieved in the final extract. This purity ratio allows for use of the extract directly as a food colourant. Then, the extract’s colourant capacity on different beverages was evaluated. The results confirm that C-phycocyanin concentrations ranging from 22 to 106 mg/L produce colours similar to commercial products, thus avoiding the need for synthetic colourants. The colour remained stable for up to 12 days. Moreover, the safety of the extracted C-phycocyanin was confirmed through toxicity tests. The waste biomass was evaluated for use as a biostimulant, with the results confirming a relevant auxin-like positive effect. Finally, an economic analysis was conducted to evaluate different scenarios. The results confirm that the production of both C-phycocyanin and biostimulants is the best scenario from an economic standpoint. Therefore, the developed biomass processing scheme provides an opportunity to expand the range of commercial applications for microalgae-related processes.
A Meta-Analysis of Infants' Mispronunciation Sensitivity Development

Before infants become mature speakers of their native language, they must acquire a robust word-recognition system which allows them to strike the balance between allowing some variation (mood, voice, accent) and recognizing variability that potentially changes meaning (e.g. cat vs hat). The current meta-analysis quantifies how the latter, termed mispronunciation sensitivity, changes over infants first three years, testing competing predictions of mainstream language acquisition theories. Our results show that infants were sensitive to mispronunciations, but accepted them as labels for target objects. Interestingly, and in contrast to predictions of mainstream theories, mispronunciation sensitivity was not modulated by infant age, suggesting that a sufficiently flexible understanding of native language phonology is in place at a young age.