Miracle-dz/UniFAR-FTUs huggingface dataset:
The Last Glacial Maximum

The Melting Is in the Details Global sea level rises and falls as ice sheets and glaciers melt and grow, providing an integrated picture of the changes in ice volume but little information about how much individual ice fields are contributing to those variations. Knowing the regional structure of ice variability during glaciations and deglaciations will clarify the mechanisms of the glacial cycle. Clark et al. (p. 710) compiled and analyzed more than 5000 radiocarbon and cosmogenic surface exposure ages in order to develop a record of maximum regional ice extent around the time of the Last Glacial Maximum. The responses of the Northern and Southern Hemispheres differed significantly, which reveals how the evolution of specific ice sheets affected sea level and provides insight into how insolation controlled the deglaciation. Regional patterns are presented of the timing of ice-sheet and mountain-glacier maxima near the end of the last ice age. We used 5704 14C, 10Be, and 3He ages that span the interval from 10,000 to 50,000 years ago (10 to 50 ka) to constrain the timing of the Last Glacial Maximum (LGM) in terms of global ice-sheet and mountain-glacier extent. Growth of the ice sheets to their maximum positions occurred between 33.0 and 26.5 ka in response to climate forcing from decreases in northern summer insolation, tropical Pacific sea surface temperatures, and atmospheric CO2. Nearly all ice sheets were at their LGM positions from 26.5 ka to 19 to 20 ka, corresponding to minima in these forcings. The onset of Northern Hemisphere deglaciation 19 to 20 ka was induced by an increase in northern summer insolation, providing the source for an abrupt rise in sea level. The onset of deglaciation of the West Antarctic Ice Sheet occurred between 14 and 15 ka, consistent with evidence that this was the primary source for an abrupt rise in sea level ~14.5 ka.
Hair simulation model for real-time environments

We present a dynamic hair animation method designed for use in real-time virtual environments. Basing on recent research results in elastic rod simulation, we introduce an enhanced physically plausible technique which utilizes specific properties of hair strands to achieve better performance and more stable simulation. Stability is also enhanced by decoupling major sources of dynamic equation stiffness into a separate post-integration step. We also use the same decoupling principle to treat hair-head collisions in a very efficient and robust way. Thanks to this, we can afford to use a fast explicit integration scheme, which, combined with a short time step, allows our method to provide smooth results even in frequency-sensitive areas such as haptics-based hair modelling.
Optimal Beamforming in Two-Way Relay Networks with Cognitive Radio Capabilities

In this paper, we present a cognitive relay network with two primary transceivers that communicate via several distributed relay terminals. Spectrum sensing is deployed at the relays to sense the absence/presence of the primary transceivers based on energy detection. The primary network utilizes a two-step two-way amplify-and-forward (AF) scheme by using the cognitive radio (CR) terminals as its relay nodes when the primary network is not in operation, in contrast, the CRs communicate with their own base station (BS). In the first relaying step, the primary transceivers send their signal to the CRs/relays. Distributed beamforming is then performed in the second relaying step. Our aim is to set the beamforming weights so as to minimize the total power dissipated in the relay network while satisfying a target signal-to-noise ratio (SNR) at the primary transceivers and at the cognitive BS. This is achieved by solving an optimization problem that we formulate as a nonconvex quadratically constrained quadratic program (QCQP). This problem is solved efficiently by semidefinite relaxation (SDR) and Lagrangian duality. Simulation results are provided to demonstrate the superiority of our proposed technique, compared to classical beamforming techniques, in terms of power reduction.
A Direct Evolutionary Feature Extraction Algorithm for Classifying High Dimensional Data

Among various feature extraction algorithms, those based on genetic algorithms are promising owing to their potential parallelizability and possible applications in large scale and high dimensional data classification. However, existing genetic algorithm based feature extraction algorithms are either limited in searching optimal projection basis vectors or costly in both time and space complexities and thus not directly applicable to high dimensional data. In this paper, a direct evolutionary feature extraction algorithm is proposed for classifying high-dimensional data. It constructs projection basis vectors using the linear combination of the basis of the search space and the technique of orthogonal complement. It also constrains the search space when seeking for the optimal projection basis vectors. It evaluates individuals according to the classification performance on a subset of the training samples and the generalization ability Df the projection basis vectors represented by the individuals. We compared the proposed algorithm with some representative feature extraction algorithms in face recognition, including the evolutionary pursuit algorithm, Eigenfaces, and Fisherfaces. The results on the widely-used Yale and ORL face databases show that the proposed algorithm has an excellent performance in classification while reducing the space complexity by an order of magnitude.
Understanding the functional difference between growth arrest-specific protein 6 and protein S: an evolutionary approach

Although protein S (PROS1) and growth arrest-specific protein 6 (GAS6) proteins are homologous with a high degree of structural similarity, they are functionally different. The objectives of this study were to identify the evolutionary origins from which these functional differences arose. Bioinformatics methods were used to estimate the evolutionary divergence time and to detect the amino acid residues under functional divergence between GAS6 and PROS1. The properties of these residues were analysed in the light of their three-dimensional structures, such as their stability effects, the identification of electrostatic patches and the identification potential protein–protein interaction. The divergence between GAS6 and PROS1 probably occurred during the whole-genome duplications in vertebrates. A total of 78 amino acid sites were identified to be under functional divergence. One of these sites, Asn463, is involved in N-glycosylation in GAS6, but is mutated in PROS1, preventing this post-translational modification. Sites experiencing functional divergence tend to express a greater diversity of stabilizing/destabilizing effects than sites that do not experience such functional divergence. Three electrostatic patches in the LG1/LG2 domains were found to differ between GAS6 and PROS1. Finally, a surface responsible for protein–protein interactions was identified. These results may help researchers to analyse disease-causing mutations in the light of evolutionary and structural constraints, and link genetic pathology to clinical phenotypes.
Ion mobility spectrometry coupled with multi-capillary columns for metabolic profiling of human breath

Recently, ion mobility spectrometry (IMS) started to be used for direct breath analysis with respect to metabolic profiling, biomarker finding and gas trace analysis. The present review describes the basic operation of an ion mobility spectrometer including the ionization process, humidity effects and sampling procedures. To enhance the resolution, pre-separation by multi-capillary columns (MCCs) is discussed and examples for IMS chromatograms are presented. The focus is to review the analytical method IMS with respect to potential use for direct investigations of humid air in direct breath analysis but not on detailed discussion of results of specific medical application of MCC/IMS or on specific analytes found in exhaled air.
Effects of Fully Open-Air [CO2] Elevation on Leaf Photosynthesis and Ultrastructure of Isatis indigotica Fort

Traditional Chinese medicine relies heavily on herbs, yet there is no information on how these herb plants would respond to climate change. In order to gain insight into such response, we studied the effect of elevated [CO2] on Isatis indigotica Fort, one of the most popular Chinese herb plants. The changes in leaf photosynthesis, chlorophyll fluorescence, leaf ultrastructure and biomass yield in response to elevated [CO2] (550±19 µmol mol–1) were determined at the Free-Air Carbon dioxide Enrichment (FACE) experimental facility in North China. Photosynthetic ability of I. indigotica was improved under elevated [CO2]. Elevated [CO2] increased net photosynthetic rate (P N), water use efficiency (WUE) and maximum rate of electron transport (J max) of upper most fully-expended leaves, but not stomatal conductance (gs), transpiration ratio (Tr) and maximum velocity of carboxylation (V c,max). Elevated [CO2] significantly increased leaf intrinsic efficiency of PSII (Fv’/Fm’) and quantum yield of PSII(ΦPS II), but decreased leaf non-photochemical quenching (NPQ), and did not affect leaf proportion of open PSII reaction centers (qP) and maximum quantum efficiency of PSII (Fv/Fm). The structural chloroplast membrane, grana layer and stroma thylakoid membranes were intact under elevated [CO2], though more starch grains were accumulated within the chloroplasts than that of under ambient [CO2]. While the yield of I. indigotica was higher due to the improved photosynthesis under elevated [CO2], the content of adenosine, one of the functional ingredients in indigowoad root was not affected.
Developmentally regulated conversion of mesenchyme to epithelium

Polarized epithelial cells perform many critical physiological functions in multicellular organisms. Recent embryological studies of the conversion of nonpolar mesenchymal cells to epithelium in the developing mouse kidney have provided vital information on the molecular mechanisms that initiate epithelial cell polarization. To become polar, the cells first attach to the basement membrane that is produced by the developing epithelial cells themselves. Of the basement membrane components, laminin has a key role in the development of epithelial cell polarity. Laminin is a multidomain glycoprotein composed of three subunits: A, B1, and B2. One binding site for epithelial cells is found in the carboxyl‐terminal part of the A chain of laminin. Antibodies reacting with this part of laminin inhibit polarization of developing epithelial cells in organ cultures of embryonic kidneys. Expression studies also suggest that the A chain of laminin is important for epithelial cell polarization; the A chain appears when the cells begin to polarize, whereas B chains are expressed at an earlier stage of development. The studies of conversion of mesenchyme to epithelium suggest that morphogenesis can be controlled by differential expression of laminin chains. —Ekblom, P. Developmentally regulated conversion of mesenchyme to epithelium. FASEB J. 3: 2141‐2150; 1989.
VLSI implementation of a conductance-based multi-synapse using switched-capacitor circuits

For neuromorphic ICs, the implemented synaptic dynamics play an important role in the complexity achievable when running networks on the overall IC. One of these ingredients for realistic dynamics are conductance-based synapses, which in contrast to current-based synapses let a neuron adapt in various ways to its input characteristics. Another ingredient is classical neuronal spike-frequency adaptation. Both are usually realized in fully-analog subthreshold circuits, making them hard to port to modern sub-100nm technologies. In contrast, we present a compact switched-capacitor (SC) model of a conductance-based synapse that can be widely configured to accurately depict e.g. NMDA, GABA or AMPA type synapses. The SC approach is inherently easy to port between technologies and its digital part benefits fully from technology scaling. We show how this synapse circuit can also be utilized to endow a neuron with spike-frequency adaptation (SFA).
25 Years of SA Nodal Cell Modeling

This review provides a brief history of modeling the spontaneous electrical activity of sinoatrial (SA) nodal cells. The first mathematical models of the pacemaker activity of these cells were published in the early 1980s. During the 25 years that followed, many more models of increasing complexity have been developed. The main characteristics of the twelve most widely used models are presented and compared.
Dutch Query Terms Spanish Query Terms German Query English QueryMerge Translate to Dutch Translate to English Translate to Spanish Translate to English Figure 1

Most approaches to cross language information retrieval assume that resources providing a direct translation between the query and document languages exist. This paper presents research examining the situation where such an assumption is false. Here, an intermediate (or pivot) language provides a means of transitive translation of the query language to that of the document via the pivot, at the cost, however, of introducing much error. The paper reports the novel approach of translating in parallel across multiple intermediate languages and fusing the results. Such a technique removes the error, raising the effectiveness of the tested retrieval system, up to and possibly above the level expected, had a direct translation route existed. Across a number of retrieval situations and combinations of languages, the approach proves to be highly effective.
p42/44 MAP Kinase-dependent and -independent Signaling Pathways Regulate Caveolin-1 Gene Expression

Caveolin-1 is a principal component of caveolae membranes in vivo. Caveolin-1 mRNA and protein expression are down-regulated in NIH 3T3 cells in response to transformation by activated oncogenes, such as H-Ras(G12V) and v-Abl. The mechanisms governing this down-regulation event remain unknown. Here, we show that caveolin-1 gene expression is directly regulated by activation of the Ras-p42/44 MAP kinase cascade. Down regulation of caveolin-1 protein expression by Ras is independent of (i) the type of activating mutation (G12V versus Q61L) and (ii) the form of activated Ras transfected (H-Ras versus K-Rasversus N-Ras). Treatment of Ras or Raf-transformed NIH 3T3 cells with a well characterized MEK inhibitor (PD 98059) restores caveolin-1 protein expression. In contrast, treatment of v-Src and v-Abl transformed NIH 3T3 cells with PD 98059 does not restore caveolin-1 expression. Thus, there must be at least two pathways for down-regulating caveolin-1 expression: one that is p42/44 MAP kinase-dependent and another that is p42/44 MAP kinase-independent. We focused our efforts on the p42/44 MAP kinase-dependent pathway. The activity of a panel of caveolin-1 promoter constructs was evaluated using transient expression in H-Ras(G12V) transformed NIH 3T3 cells. We show that caveolin-1 promoter activity is up-regulated ∼5-fold by inhibition of the p42/44 MAP kinase cascade. Using electrophoretic mobility shift assays we provide evidence that the caveolin-1 promoter (from −156 to −561) is differentially bound by transcription factors in normal and H-Ras(G12V)-transformed cells. We also show that activation of protein kinase A (PKA) signaling is sufficient to down-regulate caveolin-1 protein expression and promoter activity. Thus, we have identified two signaling pathways (Ras-p42/44 MAP kinase and PKA) that transcriptionally down-regulate caveolin-1 gene expression.
Diversity of Nitrogen Fixation Genes in the Symbiotic Intestinal Microflora of the Termite Reticulitermes speratus

The diversity of nitrogen-fixing organisms in the symbiotic intestinal microflora of a lower termite, Reticulitermes speratus, was investigated without culturing the resident microorganisms. Fragments of the nifH gene, which encodes the dinitrogenase reductase, were directly amplified from the DNA of the mixed microbial population in the termite gut and were clonally isolated. The phylogenetic analysis of the nifH product amino acid sequences showed that there was a remarkable diversity of nitrogenase genes in the termite gut. A large number of the termite nifH sequences were most closely related to those of a firmicute, Clostridium pasteurianum, with a few being most closely related to either the (gamma) subclass of the proteobacteria or a sequence of Desulfovibrio gigas. Some of the others were distantly related to those of the bacteria and were seemingly derived from the domain Archaea. The phylogenetic positions of these nifH sequences corresponded to those of genera found during a previous determination of rRNA-based phylogeny of the termite intestinal microbial community, of which a majority consisted of new, yet-uncultivated species. The results revealed that we have little knowledge of the organisms responsible for nitrogen fixation in termites.
Physical and rheological properties of crumb rubber/styrene–butadiene–styrene compound modified asphalts

In order to improve the storage stability and tenacity of crumb rubber modified (CRM) asphalt, CRM compound modified asphalt was prepared by the addition of styrene–butadiene–styrene (SBS) and sulfur. The addition of SBS improved the tenacity of CRM asphalt, due to the formation of a dense polymer network. The storage stability of crumb rubber (CR)/SBS-modified (CRSM) asphalt was improved by the addition of sulfur. The rheological tests confirmed the effect of SBS and sulfur on the physical properties of CRM asphalt to some extent and showed the susceptibility of CR/SBS/sulfur-modified (CRSSM) asphalt to dynamic shearing. The morphology observation showed the compatibility of CRSM asphalt was improved greatly by vulcanization. POLYM. COMPOS. , 2015. © 2015 Society of Plastics Engineers
A comparison of features for automatic deception detection in synchronous computer-mediated communication

This research aims to compare the performance of automatic deception detection in synchronous computer-mediated communication (CMC) with and without incorporating structural features. In addition, the development of deception detection models draws on the linguistic features that have been widely studied in the online deception literature. The results suggest that structural features can be effective in detecting deception and combining the structural features with linguistic features can improve the performance of detecting deception.
Finding Good Paths: Applications of Least Cost Caloric Path Computations

As you walk around during your daily life, you commonly make path finding decisions based on the world around you. For example, when you are walk­ ing in the outdoors, you take the path of least re­ sistance over a terrain. We present two applications which demonstrate the importance of using the least cost caloric cost path computation in two different domain settings. One application uses the popular Google Earth API to explore the use of least cost caloric path computations to create an interactive path-finding tool. The second tool uses least cost caloric path computations to enhance crowd simula­ tions in the 3D modeling and rendering application, Maya. Both applications show that considering the cost of travel from a human centered perspective can produce better results for computing good walking paths for crowds and individuals.
Artery Tertiary Lymphoid Organs Contribute to Innate and Adaptive Immune Responses in Advanced Mouse Atherosclerosis

Tertiary lymphoid organs emerge in tissues in response to nonresolving inflammation. Recent research characterized artery tertiary lymphoid organs in the aorta adventitia of aged apolipoprotein E–deficient mice. The atherosclerosis-associated lymphocyte aggregates are organized into distinct compartments, including separate T-cell areas harboring conventional, monocyte-derived, lymphoid, and plasmacytoid dendritic cells, as well as activated T-cell effectors and memory cells; B-cell follicles containing follicular dendritic cells in activated germinal centers; and peripheral niches of plasma cells. Artery tertiary lymphoid organs show marked neoangiogenesis, aberrant lymphangiogenesis, and extensive induction of high endothelial venules. Moreover, newly formed lymph node–like conduits connect the external lamina with high endothelial venules in T-cell areas and also extend into germinal centers. Mouse artery tertiary lymphoid organs recruit large numbers of naïve T cells and harbor lymphocyte subsets with opposing activities, including CD4+ and CD8+ effector and memory T cells, natural and induced CD4+ regulatory T cells, and memory B cells at different stages of differentiation. These data suggest that artery tertiary lymphoid organs participate in primary immune responses and organize T- and B-cell autoimmune responses in advanced atherosclerosis. In this review, we discuss the novel concept that pro- and antiatherogenic immune responses toward unknown arterial wall–derived autoantigens may be organized by artery tertiary lymphoid organs and that disruption of the balance between pro- and antiatherogenic immune cell subsets may trigger clinically overt atherosclerosis.
Prognosis of non-small cell lung cancer patients by detecting circulating cancer cells in the peripheral blood with multiple marker genes.

PURPOSE Current lung cancer staging and prognosis methods are based on imaging methods, which may not be sensitive enough for early and accurate detection of metastasis. This study aims to validate the use of a panel of markers for circulating cancer cell detection to improve the accuracy of cancer staging, prognosis, and as a rapid assessment of therapeutic response. EXPERIMENTAL DESIGN We analyzed the National Cancer Institute-Cancer Genome Anatomy Project database to identify potential marker genes for the detection of circulating cancer cells in peripheral blood. Nested real-time quantitative PCR and a scoring method using cancer cell load Lc were employed to correlate the amount of circulating cancer cells with clinical outcomes in 54 non-small cell lung cancer (NSCLC) patients. The Kaplan-Meier method was employed for analysis of prognostic variables. RESULTS A panel of four marker genes was identified and experimentally validated. With these marker genes, we achieved an overall positive detection rate of 72% for circulating cancer cells in the peripheral blood of NSCLC patients. Patients who had higher Lc values had worse outcomes and shorter survival times. Patients with poor therapeutic response were revealed by positive detection of circulating cancer cells after therapy. The results correlated well with the patients' survival time. CONCLUSION Circulating cancer cell detection by a panel of markers and the Lc scoring method can supplement the current tumor, node, metastasis staging method for improved prognosis and for rapid assessment of therapeutic response. Together, they may facilitate the design of better therapeutic strategies for the treatment of NSCLC patients.
Halogen bonds with benzene: An assessment of DFT functionals

The performance of an extensive set of density functional theory functionals has been tested against CCSD(T) and MP2 results, extrapolated to the complete basis set (CBS) limit, for the interaction of either DCl or DBr (D = H, HCC, F, and NC) with the aromatic system of benzene. It was found that double hybrid functionals explicitly including dispersion, that is, B2PLYPD and mPW2PLYPD, provide the better agreement with the CCSD(T)/CBS results on both energies and equilibrium geometry, indicating the importance of dispersive contributions in determining this interaction. Among the less expensive functionals, the better performance is provided by the ωB97X and M062X functionals, while the ωB97XD and B97D functionals are shown to work very well for bromine complexes but not so well for chlorine complexes. © 2013 Wiley Periodicals, Inc.