Miracle-dz/UniFAR-FTUs huggingface dataset:
Solar-Driven Syngas Production Using Al-Doped ZnTe Nanorod Photocathodes

Syngas, traditionally produced from fossil fuels and natural gases at high temperatures and pressures, is an essential precursor for chemicals utilized in industry. Solar-driven syngas production can provide an ideal pathway for reducing energy consumption through simultaneous photoelectrochemical CO2 and water reduction at ambient temperatures and pressures. This study performs photoelectrochemical syngas production using highly developed Al-doped ZnTe nanorod photocathodes (Al:ZnTe), prepared via an all-solution process. The facile photo-generated electrons are transferred by substitutional Al doping on Zn sites in one-dimensional arrays to increase the photocurrent density to −1.1 mA/cm2 at −0.11 VRHE, which is 3.5 times higher than that for the pristine ZnTe. The Al:ZnTe produces a minor CO (FE ≈ 12%) product by CO2 reduction and a major product of H2 (FE ≈ 60%) by water reduction at −0.11 VRHE. Furthermore, the product distribution is perfectly switched by simple modification of Au deposition on photocathodes. The Au coupled Al:ZnTe exhibits dominant CO production (FE ≈ 60%), suppressing H2 evolution (FE ≈ 15%). The strategies developed in this study, nanostructuring, doping, and surface modification of photoelectrodes, can be applied to drive significant developments in solar-driven fuel production.
The Role of Anti-PLA2R and Anti-THSD7A Antibodies in the Pathogenesis and Diagnostics of Primary Membranous Nephropathy: A Review of Current Knowledge for Clinical Practice

Primary membranous nephropathy (PMN) is considered a major cause of nephrotic syndrome. The discovery of circulating autoantibodies directed against glomerular podocytes helped to classify them as autoimmune diseases. Over the past years, there has been an increasing significance of anti-Phospholipase A2 Receptor (anti-PLA2R), which has been detected in 70–80% of PMN cases, and relevance of anti-Thrombospondin type I domain-containing 7A (anti-THSD7A) even though they are present in 2–5% of patients. The results of clinical and experimental studies indicate that these antibodies are pathogenic. It radically changed the diagnostic and therapeutic approach. Measurement of antibody titers in the serum seems to be a valuable tool for identifying PMN and for the assessment of disease activity. By monitoring pathogenic antibodies levels rather than proteinuria or reduced glomerular filtration rate (GFR) as an indicator of glomerular disease, physicians would easier divide patients into those with active and inactive PMN disease and decide about their therapy. The aim of this review is to evaluate scientific evidence about the role of autoantibodies, namely anti-PLA2R and anti-THSD7A, as PMN biomarkers. The present manuscript focuses on PMN pathogenesis and key data of diagnosis, monitoring of the disease, and treatment strategies that are currently being used in clinical practice.
PENGEMBANGAN MEDIA TRAINER ARDUINO UNO PADA MATA PELAJARAN TEKNIK MIKROPROSESOR DI SMKN 2 SURABAYA

Tujuan penelitian ini adalah mengetahui tingkat validitas trainer arduino uno yang dikembangkan sebagai media pembelajaran pada mata pelajaran mikroprosesor. Mengetahui respon siswa terhadap trainer Arduino Uno beserta jobsheet yang digunakan sebagai media pembelajaran pada mata pelajaran Teknik Mikroprosesor. Selain itu bertujuan mengetahui hasil belajar siswa setelah menggunakan trainer dan jobsheet pada mata pelajaran mikroprosesor. Jenis penelitian ini adalah jenis penelitian pengembangan Research and development (R&D). Pada penelitian ini penulis melakukan 7 langkah dari R&D diantaranya adalah potensi dan masalah, pengumpulan data, desain produk, validasi desain, revisi desain, uji coba produk, analisis dan pelaporan. Dari hasil penelitian diperoleh (1) berdasarkan analisis hasil validasi diperoleh rating validasi trainer sebesar 82.29% dengan kategori sangat baik, hasil rating validasi jobsheet sebesar 81.59% dengan kategori baik, dan hasil rating validasi soal sebesar 78%. (2) observasi dari hasil belajar pada kegiatan belajar secara keseluruhan sangat baik dengan rata-rata 83,67%. Dari hasil rating tersebut dideskripsikan bahwa media trainer beserta jobsheet layak digunakan sehingga siswa mendapat hasil belajar yang sangat baik dan mampu menggunakan, memahami jobsheet yang telah dibuat. Kata Kunci: Pengembangan trainer, Research and Development, hasil belajar.
β-Arrestin2 Is Critically Involved in the Differential Regulation of Phosphosignaling Pathways by Thyrotropin-Releasing Hormone and Taltirelin

In recent years, thyrotropin-releasing hormone (TRH) and its analogs, including taltirelin (TAL), have demonstrated a range of effects on the central nervous system that represent potential therapeutic agents for the treatment of various neurological disorders, including neurodegenerative diseases. However, the molecular mechanisms of their actions remain poorly understood. In this study, we investigated phosphosignaling dynamics in pituitary GH1 cells affected by TRH and TAL and the putative role of β-arrestin2 in mediating these effects. Our results revealed widespread alterations in many phosphosignaling pathways involving signal transduction via small GTPases, MAP kinases, Ser/Thr- and Tyr-protein kinases, Wnt/β-catenin, and members of the Hippo pathway. The differential TRH- or TAL-induced phosphorylation of numerous proteins suggests that these ligands exhibit some degree of biased agonism at the TRH receptor. The different phosphorylation patterns induced by TRH or TAL in β-arrestin2-deficient cells suggest that the β-arrestin2 scaffold is a key factor determining phosphorylation events after TRH receptor activation. Our results suggest that compounds that modulate kinase and phosphatase activity can be considered as additional adjuvants to enhance the potential therapeutic value of TRH or TAL.
PID Augmented Stability of Multi-Rotor Helicopters

This paper is a general theoretical formalization of the design of linear controllers for ight stabilization of multirotor helicopters. After the description of the linear dynamic modelling of this type of aircraft, the plants transfer functions are obtained for the sizing of PID regulators. The gains of the controllers that assure the dynamic stability of the system, in a purely analytical way, are then computed. These gains are given as functions of the aerodynamic and mechanical features of the aircraft. All in closed form expressions, these results represent the rst exact solution to the problem of stabilization of attitude and velocity of this type of aircraft, through linear PID control. Aordable tools useful to a quick hand calculation for control systems tuning, dynamic stability evaluation, multirotor aircraft design and also for academic educational purposes are thus provided and then tested in a numeric simulation.
Evaluation of Women’s Age and Ultrasonographic Features to Choose Surgical Treatment for Endometriosis Associated with Ovarian Cancer

Adequate surgical management of malignant endometriosis remains a clinical challenge in gynecology. Age, sonography variables, and tumor biomarkers have been reported as candidates in the clinical decision. This study aims were to analyze the factors of women’s age, body mass index, ultrasound features, and tumor biomarkers to predict endometriosis-associated ovarian cancer in a large series of endometriomas and to study the surgical treatment performed in this cohort. In this retrospective study, we reviewed the medical records of patients with ultrasound diagnosis of ovarian cyst classified as endometrioma (benign as well as with risk of malignancy), surgically treated in the endometriosis unit of Hospital Universitario La Paz (Madrid, Spain) between January 2019 and July 2021. According to the final histology examination, the women were clustered as non-endometriosis-associated ovarian cancer (OE, benign endometriomas, n = 59) and endometriosis-associated ovarian cancer (EAOC) (n = 17). Demographic, clinical, and surgical data were collected from these women. International Ovarian Tumor Analysis (IOTA) criteria were assessed for the ultrasound examination. The age of the women in the EAOC group was 50.0 [43.0; 63.0] years, which was significantly higher than OE (39.0 [34.0; 46.0] years; p-value < 0.001). In addition, the body mass index for the OE group (24.9 ± 5.3 kg/m2) was significantly higher than for the EAOC group (23.3 ± 4.6 kg/m2; p-value < 0.001). However, the tumor biomarker levels (CA 125, CA 19.9 and He4) were not significantly different among the groups. We performed 51.4% cystectomies and 48.6% adnexectomies, with an association between the adnexectomy and EAOC group (p-value < 0.001). In addition, a significant association was found between ultrasound features suspicious for malignancy and the EAOC group. Conclusively, women’s age and ultrasound features, such as papillary projections, septa, and positive echo-Doppler, were the main factors to consider when evaluating the malignancy risk associated with endometriosis.
Aronia melanocarpa Fruit Juice Modulates ACE2 Immunoexpression and Diminishes Age-Related Remodeling of Coronary Arteries in Rats

The aim of the study is to evaluate the effect of Aronia melanocarpa fruit juice (AMJ) supplementation on age-related coronary arteries remodeled in aged rat hearts. Male Wistar rats (n = 24) were divided into three groups: (1) young controls (CY), aged 2 months, without AMJ supplementation; (2) old controls (CO), aged 27 months, without AMJ supplementation; and (3) the AMJ group (A), which used 27-month old animals, supplemented orally with AMJ for 105 days. AMJ supplementation did not influence the wall-to-diameter parameter (Kernohan index) of the coronary arteries of test animals. Aged rats supplemented with AMJ showed a significant decrease in the amount of collagen fibers in their coronary tunica media, as compared with the old controls. The intensity of the immunoreaction for alpha smooth muscle actin (αSMA) in the coronary tunica media was significantly lower in the supplemented group than in the old controls. The intensity of the angiotensin-converting enzyme 2 (ACE2) immunoreaction in the coronary tunica media of the supplemented group was significantly higher than the one observed in the old controls. These results indicate the positive effects of AMJ supplementation on the age-dependent remodeling of coronary arteries and support for the preventive potential of antioxidant-rich functional food supplementation in age-related diseases.
Dietary Supplementation with Agave tequilana (Weber Var. Blue) Stem Powder Improves the Performance and Intestinal Integrity of Broiler Rabbits

Simple Summary Natural products have been used as an alternative to the indiscriminate use of subtherapeutic antibiotics for improving the growth of animals. Although these synthetic products have been used in rabbits to a lesser extent than in other monogastrics, several natural products have been tested with positive responses in growth performance, immune activity, and antioxidant capacity. Agaves are plants with chemical compounds that have shown positive effects on performance and animal health. Specifically, the Agave tequilana stem has a high content of fructans and secondary metabolites, such as polyphenols and saponins, that are responsible for various biological activities. The dietary use of up to 1.5% of Agave tequilana stem powder in the diet of rabbits had a natural growth-promoting effect due to the improvement of their intestinal integrity (with an emphasis on the concentric layers, villi, and crypts), taken as indicator of intestinal health. Considering the results of this study and others carried out by this group of authors, this natural product (A. tequilana) could be utilized in rabbit farming, considering that the stem of the agave is currently not utilized for anything. Abstract This study evaluated the effect of Agave tequilana (Weber var. azul) stem powder on the growth performance and the intestinal integrity in rabbits. A total of 120 male rabbits [New Zealand × California] were weaned for 35 days and randomized into four dietary treatments, 15 replicates per treatment, and two rabbits per replicate. The treatments consisted of a basal diet (T0) and dietary supplementation with 0.5% (T1), 1.0% (T2) and 1.5% (T3) of Agave tequilana stem powder. The T3 treatment improved the body weight and average daily gain (p < 0.05) compared to the other groups, without affecting viability and feed conversion ratio (p > 0.05). Furthermore, the T3 treatment enhanced (p < 0.05) the thickness of the muscular and mucous layers, and the height, thickness, and number of villi in the duodenum (p < 0.05). However, this treatment (T3) significantly decreased (p < 0.05) values for the area and depth of the crypts in the duodenum and the villus/crypt ratio. Likewise, in the cecum, T3 treatment provoked a marked decrease (p < 0.05) in the depth and thickness of the crypts. The results indicate that the dietary use with 1.5% of A. tequilana stem powder had a natural growth-promoting effect and enhanced the histomorphometry of the concentric layers (muscle and mucosa), villi, and crypts as indicators of intestinal health in rabbits.
Anti-Hyperlipidemia, Hypoglycemic, and Hepatoprotective Impacts of Pearl Millet (Pennisetum glaucum L.) Grains and Their Ethanol Extract on Rats Fed a High-Fat Diet

This study tested the anti-hyperlipidemic, hypoglycemic, hepatoprotective, and anti-inflammatory effects of whole pearl millet grain powder (MPG) and its ethanol extract (MPGethaolE) in obese rats fed a high-fat diet. The rats were divided into eight groups based on the treatments they received: control, high fat diet (HFD), HFD + MGE (25 mg/Kg), HFD + MPGethaolE (50 mg/Kg), HFD + MPGethaolE (100 mg/Kg), HFD + MPG (10%), HFD + MPG (20%), and HFD + MPG (30%). The final body weight, visceral, epididymal fat pads, and the liver weight were significantly decreased, in a dose-dependent manner, in HFD fed rats that were co-administered either the MPG powder or MPGethaolE. In the same line, serum levels of triglycerides (TGs), cholesterol (CHOL), and low-density lipoprotein-cholesterol (LDL-c), as well as fasting glucose, insulin, HOMA-IR, and serum levels of lipopolysaccharides (LPS), interleukine-6 (IL-6), interleukine-10 (IL-10), C-reactive protein (CRP), tumor necrosis factor (TNF-α), and adiponectin were progressively decreased while serum levels of high-density lipoproteins (HDL-c) were significantly increased when increasing the doses of both treatments. In conclusion, both the raw powder and ethanolic extract of MP have a comparative dose-dependent anti-obesity, hypoglycemic, hypolipidemic, anti-inflammatory, and anti-steatotic in HFD-fed rats.
Mis–Dis Information in COVID-19 Health Crisis: A Narrative Review

Background: In this narrative review, we address the COVID-19 pandemic mis–dis information crisis in which healthcare systems have been pushed to their limits, with collapses occurring worldwide. The context of uncertainty has resulted in skepticism, confusion, and general malaise among the population. Informing the public has been one of the major challenges during this pandemic. Misinformation is defined as false information shared by people who have no intention of misleading others. Disinformation is defined as false information deliberately created and disseminated with malicious intentions. Objective: To reach a consensus and critical review about mis–dis information in COVID-19 crisis. Methods: A database search was conducted in PsychINFO, MedLine (Pubmed), Cochrane (Wiley), Embase and CinAhl. Databases used the MeSH-compliant keywords of COVID-19, 2019-nCoV, Coronavirus 2019, SARS-CoV-2, misinformation, disinformation, information, vaccines, vaccination, origin, target, spread, communication. Results: Both misinformation and disinformation can affect the population’s confidence in vaccines (development, safety, and efficacy of vaccines, as well as denial of the severity of SARS-CoV infection). Institutions should take into account that a great part of the success of the intervention to combat a pandemic has a relationship with the power to stop the misinformation and disinformation processes. The response should be well-structured and addressed from different key points: central level and community level, with official and centralized communication channels. The approach should be multifactorial and enhanced by the collaboration of social media companies to stop misleading information, and trustworthy people both working or not working in the health care systems to boost the power of the message. Conclusions: The response should be well-structured and addressed from different key points: central level and community level, with official and clearly centralized communication channels. The approach should be multifactorial and enhanced from the collaboration of social media companies to stop misleading information, and trustworthy people both working and not working in the health care systems to boost the power of a message based on scientific evidence.
EFFECT OF L-TRYPTOPHAN ON PLANT WEIGHT AND POD WEIGHT IN CHICKPEA UNDER RAINFED CONDITIONS

Exogenous application of plant growth regulators is an important element in modern day agricultural production technology. The precursor of auxin, L-Tryptophan (L-TRP), is the most important plant growth regulator and is physiologically very vital in modelling plant growth and development. To evaluate the effect of L-TRP on chickpea plant weight and pod weight, a field experiment was conducted during 2003, employing randomised complete block design under rain-fed conditions. The treatments were L-TRP @ 10 -2 M, L-TRP @ 10 -3 M, L-TRP @ 10 -4 M and a control. Analysis showed that L-TRP @ 10 -3 M had a significant effect on plant and pod weight, suggesting the additional effect of plant growth promoting factor provided by auxin production. The L-TRP improved the crop vegetative and reproductive growth that consequently increases pod weight.
High-Dose Chemotherapy with Autologous Hematopoietic Stem Cell Transplantation in Relapsed or Refractory Primary CNS Lymphoma: A Retrospective Monocentric Analysis of Long-Term Outcome, Prognostic Factors, and Toxicity

Simple Summary No standard treatment is defined for relapsed or refractory (r/r) primary CNS lymphoma (PCNSL). However, high-dose chemotherapy with autologous stem cell transplantation (HCT-ASCT), an efficient first line treatment in younger PCNSL patients, is commonly applied in relapsed or refractory disease, if tolerable. Here, we retrospectively analyzed 59 patients with r/r PCNSL focusing specifically on differences in long-term outcome and toxicity in patients <65 years (n = 33) and ≥65 years (n = 26) of age. Abstract High-dose chemotherapy with autologous stem cell transplantation (HCT-ASCT) is reportedly an effective treatment strategy in relapsed or refractory primary CNS lymphoma (r/r PCNSL); however, only selected patients are eligible for this treatment. We retrospectively analyzed outcome, prognostic factors, and toxicity in 59 patients with r/r PCNSL planned to receive HCT-ASCT at our institution between January 2005 and December 2021 (n = 33 < 65 years; n = 26 ≥ 65 years). Median follow-up was 65 months (95% CI 21–109). Median age was 63 years (range 29–76), median Karnofsky performance score (KPS) was 80 (range 30–100). In the entire cohort of 59 patients, median overall survival (OS) was 14 months (95% CI 0–37). In 50/59 (84.7%) patients who completed HCT-ASCT, median progression free survival (PFS) was 12 months (95% CI 3–21) and median OS 30 months (95% CI 0–87). 1-year, 2-year, and 5-year OS rates of 61.2%, 52.3% and 47.1%, respectively, were observed. Six patients (10.2%) died related to treatment (1 during induction treatment, 5 post HCT-ASCT). Age was not prognostic. On univariate analysis, KPS ≥ 80 (p = 0.019) and complete or partial remission before HCT-ASCT (p = 0.026) were positive prognosticators of OS; on multivariate analysis, KPS (p = 0.043) and male gender (p = 0.039) had an impact on OS. The 5-year OS rate in patients with progressive or stable disease after induction treatment was 32.7%. In summary, HCT-ASCT was effective and feasible in this cohort of r/r PCNSL patients. Clinical state, remission status before HCT-ASCT, and gender influenced survival, whereas age did not influence outcome in this study.
Neurochemical Alterations in Social Anxiety Disorder (SAD): A Systematic Review of Proton Magnetic Resonance Spectroscopic Studies

(1) Objective: Considering that current knowledge of mechanisms involved in the molecular pathogenesis of Social Anxiety Disorder (SAD) is limited, we conducted a systematic review to evaluate cumulative data obtained by Proton Magnetic Resonance Spectroscopic (1H MRS) studies. (2) Methods: A computer-based literature search of Medline, EMBASE, PsycInfo, and ProQuest was performed. Only cross-sectional studies using 1H MRS techniques in participants with SAD and healthy controls (HCs) were selected. (3) Results: The search generated eight studies. The results indicated regional abnormalities in the ‘fear neurocircuitry’ in patients with SAD. The implicated regions included the anterior cingulate cortex (ACC), dorsomedial prefrontal cortex (dmPFC), dorsolateral prefrontal cortex (dlPFC), insula, occipital cortex (OC), as well as the subcortical regions, including the thalamus, caudate, and the putamen. (4) Conclusions: The evidence derived from eight studies suggests that possible pathophysiological mechanisms of SAD include impairments in the integrity and function of neurons and glial cells, including disturbances in energy metabolism, maintenance of phospholipid membranes, dysregulations of second messenger systems, and excitatory/inhibitory neurocircuitry. Conducting more cross-sectional studies with larger sample sizes is warranted given the limited evidence in this area of research.
Deviations of the SLM Produced Lattice Structures and Their Influence on Mechanical Properties

Selective laser melting (SLM) is an additive manufacturing technology suitable for producing cellular lattice structures using fine metal powder and a laser beam. However, the shape and dimensional deviations occur on the thin struts during manufacturing, influencing the mechanical properties of the structure. There are attempts in the literature to describe the actual shape of the struts’ geometry, however, on a smaller data sample only, and there is a lack of a universal FEA material model applicable to a wider range of lattice structure diameters. To describe the actual dimensions of the struts, a set of lattice structures, with diameters ranging from 0.6 to 3.0 mm, were manufactured using SLM. These samples were digitized using micro-computed tomography (μCT) and fully analyzed for shape and dimensions. The results show large deviations in diameters of inscribed and circumscribed cylinders, indicating an elliptical shape of the struts. With increasing lattice structure diameter, the deviations decreased. In terms of the effect of the shape and dimensions on the mechanical properties, the Gaussian cylinder was found to describe struts in the diameter range of 1.5 to 3.0 mm sufficiently well. For smaller diameters, it is appropriate to represent the actual cross-section by an ellipse. The use of substitute ellipses, in combination with the compression test results, has resulted in FEA material model that can be used for the 0.6 to 3.0 mm struts’ diameter range. The model has fixed Young’s and tangential modules for these diameters and is controlled only by the yield strength parameter (YST).