Miracle-dz/UniFAR-FTUs huggingface dataset:
3D chemical mapping of ‘Mn–caldera shaped zoning’ garnet found from the Sanbagawa metamorphic belt of the Besshi district, SW Japan

Garnet with a complex compositional zoning was found from the northern edge of the Western Iratsu body in the Sanbagawa metamorphic belt of the Besshi district, southwest Japan. The studied garnet shows incipient Mn–reverse (increase) zoning from the center part and subsequent Mn–bell shape type (decrease) zoning towards the outer part, which is almost identical to the ‘Mn–caldera shaped zoning’ described by Xu et al. (1994) and Banno and Nakamura (2004). In order to display the chemical characteristics sterically, three–dimensional X–ray chemical mapping was performed for one very–coarse grain of garnet. The result clearly displays that there is a high–Mn layer with faceted euhedral shape of the garnet at the intermediate part, and that its composition continuously changes from the inside to the outside. Inclusion arrays in garnet getting across the high– Mn layer also suggest the continuous growth of the garnet. In the same sample, garnets without Mn–caldera shaped zoning are ubiquitously observed, which are relatively small in size up to 5 mm in diameter. Inclusion mineral assemblage in garnet and Raman barometry suggest the peak P–T conditions of the studied sample not having reached the eclogite facies, but being the epidote–amphibolite facies. The formation process of the ‘Mn– caldera shaped zoning’ can be best explained by the disequilibrium crystal growth under oversaturation of garnet in MnO–(MgO + FeO) binary system. Such oversaturation can be triggered by rapid heating. The finding of the remnant of rapid heating event would provide an important clue to discuss the exhumation history of the Sanbagawa metamorphic belt.
The complex frequencies of long‐period seismic events as probes of fluid composition beneath volcanoes

Summary Long-period (LP) events have been widely observed in relation to magmatic and hydrothermal activities in volcanic areas. LP waveforms characterized by their harmonic signature have been interpreted as oscillations of a fluid-filled resonator, and mixtures of liquid and gas in the form of bubbly liquids have been mainly assumed for the fluid. To investigate the characteristic properties of the resonator system, we analyse waveforms of LP events observed at four different volcanoes in Hawaii, Alaska, Colombia and Japan using a newly developed spectral method. This method allows an estimation of the complex frequencies of decaying sinusoids based on an autoregressive model. The results of our analysis show a wide variety of Q factors, ranging from tens to several hundred. We compare these complex frequencies with those predicted by the fluid-filled crack model for various mixtures of liquid, gas and ash. Although the oscillations of LP events with Q smaller than 50 can be explained by various combinations of liquids and gases, we find that ash-laden gases are required to explain long-lasting oscillations with Q larger than 100. The complex frequencies of LP events yield useful information on the types of fluids. Temporal and spatial variations of the complex frequencies can be used as probes of fluid composition beneath volcanoes.
Cannabidiol as an Alternative Analgesic for Acute Dental Pain

Odontogenic pain can be debilitating, and nonopioid analgesic options are limited. This randomized placebo-controlled clinical trial aimed to assess the effectiveness and safety of cannabidiol (CBD) as an analgesic for patients with emergency acute dental pain. Sixty-one patients with moderate to severe toothache were randomized into 3 groups: CBD10 (CBD 10 mg/kg), CBD20 (CBD 20 mg/kg), and placebo. We administered a single dose of respective oral solution and monitored the subjects for 3 h. The primary outcome measure was the numerical pain differences using a visual analog scale (VAS) from baseline within and among the groups. Secondary outcome measures included ordinal pain intensity differences, the onset of significant pain relief, maximum pain relief, changes in bite force within and among the groups, psychoactive effects, mood changes, and other adverse events. Both CBD groups resulted in significant VAS pain reduction compared to their baseline and the placebo group, with a maximum median VAS pain reduction of 73% from baseline pain at the 180-min time point (P < 0.05). CBD20 experienced a faster onset of significant pain relief than CBD10 (15 versus 30 min after drug administration), and both groups reached maximum pain relief at 180-min. Number needed to treat was 3.1 for CBD10 and 2.4 for CBD20. Intragroup comparisons showed a significant increase in bite forces in both CBD groups (P < 0.05) but not in the placebo group (P > 0.05). CBD20 resulted in a significant difference in mean percent bite force change in the 90- and 180-min time points compared to the placebo group (P < 0.05). Compared to placebo, sedation, diarrhea, and abdominal pain were significantly associated with the CBD groups (P < 0.05). There were no other significant psychoactive or mood change effects. This randomized trial provides the first clinical evidence that oral CBD can be an effective and safe analgesic for dental pain.
Distribution and Habitat Use by 'Hemidactylus frenatus' Dumeril and Bibron (Gekkonidae) in the Northern Territory

'Hemidactylus frenatus' is an invasive gecko with an expanding distribution in Australia. We collated all available locality records and investigated the habitats associated with the species in the Northern Territory. 'H. frenatus' is more widespread in the Top End, Gulf of Carpentaria and Victoria River regions than previously documented. The species remains primarily associated with artificial anthropogenic structures and surrounding vegetation (particularly denser tropical forests), but there are also a small number of records of it living in natural vegetation further than 1 km from such structures. We speculate that H. frenatus will continue to spread through suitable habitats in northern Australia.
The Use of Sand Fences in Barrier Island Restoration: Experience on the Louisiana Coast

Abstract : This System-Wide Water Resources (SWWRP) technical note describes experiences with sand fences to reduce losses by wind-blown sand transport on restored barrier islands in Louisiana. Seven installations of sand fences with various plan view orientations and cross-sectional designs are reviewed. Recommendations are given for use of sand fences in conjunction with restoration of barrier island systems.
A Global Search for Triggered Tremor Following the 2011 Mw 9.0 Tohoku Earthquake

Abstract The 2011 M w 9.0 Tohoku, Japan, earthquake triggered deep tectonic tremor and shallow microearthquakes in numerous places worldwide. Here, we conduct a systematic survey of triggered tremor in regions where ambient or triggered tremor has been previously identified. Tremor was triggered in the following regions: south‐central Alaska, the Aleutian Arc, Shikoku in southwest Japan, the North Island of New Zealand, southern Oregon, the Parkfield–Cholame section of the San Andreas fault in central California, the San Jacinto fault in southern California, Taiwan, and Vancouver Island. We find no evidence of triggered tremor in the Calaveras fault in northern California. One of the most important factors in controlling the triggering potential is the amplitude of the surface waves. Data examined in this study suggest that the threshold amplitude for triggering tremor is ∼0.1 cm/s, which is equivalent to a dynamic stress threshold of ∼10 kilopascals. The incidence angles of the teleseismic surface waves also affect the triggering potentials of Love and Rayleigh waves. The results of this study confirm that both Love and Rayleigh waves contribute to triggering tremor in many regions. In regions where both ambient and triggered tremor are known to occur, tremor triggered by the Tohoku event generally occurred at similar locations with previously identified ambient and/or triggered tremor, further supporting the notion that although the driving forces of triggered and ambient tremor differ, they share similar mechanisms. We find a positive relationship between the amplitudes of the triggering waves and those of the triggered tremor, which is consistent with the prediction of the clock‐advance model. Online Material: Table of measured parameters and other information related to triggering/nontriggering information, and figures of observed seismograms.
Review of Genotoxic Effects for Pesticides Exposure among Rural Community in a Farming Village

Background: Past studies have suggested that early exposure of farm children to chronic pesticides were likely to establish genotoxic risk that might lead to cancerous cell development later during their adulthood (if not repaired properly). Objective: This review aims to fill the knowledge gap concerning the genotoxic effect on the rural community in a farming village from exposure to a mixture of pesticides. Original Research Article How et al.; BJMMR, 10(2): 1-7, 2015; Article no.BJMMR. 19402 2 Results: This review paper shows substantial evidence that farmers were vulnerable to pesticide exposure, however, limited evidence shows that children are at an increased or equivalent risk in terms of the genotoxic effect when considering their exposure to the contaminated environment. Conclusion: This paper summarizes the existing state of knowledge concerning the genotoxic effects from pesticide exposure among farmers and their children, and highlights the genotoxic effect of pesticides as a health risk for future studies.
Current perspectives on prevention of vascular cognitive impairment and promotion of vascular brain health

ABSTRACT Introduction The true global burden of vascular cognitive impairment (VCI) is unknown. Reducing risk factors for stroke and cardiovascular disease would inevitably curtail VCI. Areas Covered The authors review current diagnosis, epidemiology, and risk factors for VCI. VCI increases in older age and by inheritance of known genetic traits. They emphasize modifiable risk factors identified by the 2020 Lancet Dementia Commission. The most profound risks for VCI also include lower education, cardiometabolic factors, and compromised cognitive reserve. Finally, they discuss pharmacological and non-pharmacological interventions. Expert Opinion By virtue of the high frequencies of stroke and cardiovascular disease the global prevalence of VCI is expectedly higher than prevalent neurodegenerative disorders causing dementia. Since ~ 90% of the global burden of stroke can be attributed to modifiable risk factors, a formidable opportunity arises to reduce the burden of not only stroke but VCI outcomes including progression from mild to the major in form of vascular dementia. Strict control of vascular risk factors and secondary prevention of cerebrovascular disease via pharmacological interventions will impact on burden of VCI. Non-pharmacological measures by adopting healthy diets and encouraging physical and cognitive activities and urging multidomain approaches are important for prevention of VCI and preservation of vascular brain health.
Pathogenic Germline Variants in BRCA1/2 and p53 Identified by Real-world Comprehensive Cancer Genome Profiling Tests in Asian Patients

Abstract Cancer genome profiling (CGP) occasionally identifies pathogenic germline variants (PGV) in cancer susceptibility genes (CSG) as secondary findings. Here, we analyzed the prevalence and clinical characteristics of PGVs based on nationwide real-world data from CGP tests in Japan. We analyzed the genomic information and clinical characteristics of 23,928 patients with solid cancers who underwent either tumor-only (n = 20,189) or paired tumor-normal (n = 3,739) sequencing CGP tests between June 2019 and December 2021 using the comprehensive national database. We assigned clinical significance for all variants and highlighted the prevalence and characteristics of PGVs. Our primary analysis of the tumor-normal sequencing cohort revealed that 152 patients (4.1%) harbored PGVs in 15 CSGs. Among 783 germline variants, 113 were annotated as PGVs, 70 as benign variants, and 600 as variants of uncertain significance. The number of PGVs identified was highest in BRCA1/2, with 56, followed by TP53, with 18. PGVs were the most prevalent in ovarian and peritoneal cancers, including among cancer types common in Asia. In the tumor-only sequencing cohort, of the 5,184 pathogenic somatic variants across 26 CSGs, 784 (15.1%) were extracted according to the European Society for Medical Oncology recommendations for germline-focused tumor analysis. The prevalence of PGVs was similar to that previously reported in Europe and the United States. This is the largest analysis based on real-world tumor-normal sequencing tests in Asia. The more widespread use of the tumor-normal sequencing CGP test could be reasonable for evaluating PGVs. Significance: We analyzed real-world data from over 23,000 patients in Japan, revealing 4.1% harbored PGVs, particularly in BRCA1/2 and TP53, in CSGs. It highlights the prevalence of PGVs in Asian populations and supports the broader adoption of tumor-normal sequencing CGP tests for PGV evaluation.
Supplementation of Energy Drinks with Green Tea Extract: Effect on In Vitro Abrasive/Erosive Dentin Wear.

PURPOSE To investigate the effect of the supplementation of energy drinks with green tea extract on abrasive and erosive dentin wear. MATERIALS AND METHODS Six groups, each comprising 15 bovine dentin samples, were prepared, yielding a total of 90 samples. Erosion was performed by immersing the samples in Red Bull and Red Bull light with and without green tea extract. Tap water with and without green tea extract was used as the control groups. The samples were subjected to abrasive/erosive cycling for five days. The following cycling was performed daily: toothbrush abrasion (20 brushstrokes; 2.5 N); eight erosive cycles (2 min storage in the respective solutions); in between the erosive cycles, storage in artificial saliva (60 min) and again toothbrush abrasion (20 brushstrokes; 2.5 N). During the night, samples were again stored in artificial saliva. Abrasive/erosive dentin wear was measured using a stylus profilometer (µm, accuracy = 40 nm). The measured dentin loss results from the vertical position shift on the y-axis from base to final profile after the wear process in 2D. Pairwise comparisons between the groups were carried out using Wilcoxon signed-rank test. RESULTS The following dentin wear (median [IQR]) was measured: Red Bull: 1.9 µm (0.5); Red Bull Light: 1.3 µm (0.3); Red Bull with green tea extract: 0.8 µm (0.3); Red Bull Light with green tea extract: 0.3 µm (0.5); Tap water with green tea extract: -0.2 µm (0.7); Tap water: -1.0 µm (1.2). The comparison of all tested groups to each other proved to be statistically significant (p < 0.05). CONCLUSION The supplementation of energy drinks with green tea extract provide a protective effect against erosive/abrasive wear in vitro.
Seasonal trends in antidepressant prescribing, depression, anxiety and self-harm in adolescents and young adults: an open cohort study using English primary care data

Background There is an increasing demand for mental health services for young people, which may vary across the year. Objective To determine whether there are seasonal patterns in primary care antidepressant prescribing and mental health issues in adolescents and young adults. Methods This cohort study used anonymised electronic health records from general practices in England contributing to QResearch. It included 5 081 263 males and females aged 14–18 (adolescents), 19–23 and 24–28 years between 2006 and 2019. The incidence rates per 1000 person-years and the incidence rate ratios (IRRs) were calculated for the first records of a selective serotonin reuptake inhibitor (SSRI) prescription, depression, anxiety and self-harm. The IRRs were adjusted for year, region, deprivation, ethnic group and number of working days. Findings There was an increase in SSRI prescribing, depression and anxiety incidence in male and female adolescents in the autumn months (September–November) that was not seen in older age groups. The IRRs for SSRI prescribing for adolescents peaked in November (females: 1.75, 95% CI 1.67 to 1.83, p<0.001; males: 1.72, 95% CI 1.61 to 1.84, p<0.001, vs in January) and for depression (females: 1.29, 95% CI 1.25 to 1.33, p<0.001; males: 1.29, 95% CI 1.23 to 1.35, p<0.001). Anxiety peaked in November for females aged 14–18 years (1.17, 95% CI 1.13 to 1.22, p<0.001) and in September for males (1.19, 95% CI 1.12 to 1.27, p<0.001). Conclusions There were higher rates of antidepressant prescribing and consultations for depression and anxiety at the start of the school year among adolescents. Clinical implications Support around mental health issues from general practitioners and others should be focused during autumn.
A Two-Stage Automatic System for Detection of Interictal Epileptiform Discharges from Scalp Electroencephalograms

Abstract The objective of this work was to develop a deep learning-based automatic system with reliable performance in detecting interictal epileptiform discharges (IEDs) from scalp electroencephalograms (EEGs). For the present study, 484 raw scalp EEG recordings were included, standardized, and split into 406 for training and 78 for testing. Two neurophysiologists individually annotated the recordings for training in channel-wise manner. Annotations were divided into segments, on which nine deep neural networks (DNNs) were trained for the multiclassification of IED, artifact, and background. The fitted IED detectors were then evaluated on 78 EEG recordings with IED events fully annotated by three experts independently (majority agreement). A two montage-based decision mechanism (TMDM) was designed to determine whether an IED event occurred at a single time instant. Area under the precision–recall curve (AUPRC), as well as false-positive rates, F1 scores, and kappa agreement scores for sensitivity = 0.8 were estimated. In multitype classification, five DNNs provided one-versus-rest AUPRC mean value >0.993 using fivefold cross-validation. In IED detection, the system that had integrated the temporal convolutional network (TCN)-based IED detector and the TMDM rule achieved an AUPRC of 0.811. The false positive was 0.194/min (11.64/h), and the F1 score was 0.745. The agreement score between the system and the experts was 0.905. The proposed framework provides a TCN-based IED detector and a novel two montage-based determining mechanism that combined to make an automatic IED detection system. The system would be useful in aiding clinic EEG interpretation.
Efficacy of a Spearmint (Mentha spicata L.) Extract as Nutritional Support in a Rat Model of Hypertensive Glaucoma

Purpose Glaucoma is an eye–brain axis disorder characterized by loss of retinal ganglion cells (RGCs). Although the role of intraocular pressure (IOP) elevation in glaucoma has been established, the reduction of oxidative stress and inflammation has emerged as a promising target for neuronal tissue–supporting glaucoma management. Therefore, we evaluated the effect of a proprietary spearmint extract (SPE) on RGC density, activity, and neuronal health markers in a rat model of hypertensive glaucoma. Methods Animals were divided in four groups: untreated healthy control and three glaucomatous groups receiving orally administered vehicle, SPE-low dose, or SPE-high dose for 28 days. Ocular hypertension was induced through intracameral injection of methylcellulose at day 15. At day 29, rats underwent electroretinogram (ERG) recordings, and retinas were analyzed for RGC density and markers of neural trophism, oxidative stress, and inflammation. Results SPE exerted dose-dependent response benefits on all markers except for IOP elevation. SPE significantly improved RGC-related ERG responses, cell density, neurotrophins, oxidative stress, and inflammation markers. Also, in SPE-high rats, most of the parameters were not statistically different from those of healthy controls. Conclusions SPE, a plant-based, polyphenolic extract, could be an effective nutritional support for neuronal tissues. Translational Relevance These results suggest that SPE not only may be a complementary approach in support to hypotensive treatments for the management of glaucoma but may also serve as nutritional support in other ocular conditions where antioxidant, anti-inflammatory, and neuroprotective mechanism are often disrupted.
Proximate Composition, Minerals Content and Functional Properties of Five Lima Bean Accessions

In order to combat food insecurity in Ghana and Africa as a whole, efforts are being made by the Crops Research Institute, of the Council for Scientific and Industrial Research (CSIR), Ghana, to produce new bean varieties with improved characteristics such as high yield, disease resistance and high nutritional value. Some of the new lima bean (Phaseolus lunatus) accessions collected include: Koloenu white, Koloenu brown, Nsawam black and white, Ohwam Mampong and Koloenu small black and white. The objective of the present work was to evaluate the proximate composition, minerals content and functional properties of flour from these five lima bean accessions. The proximate and functional properties were determined using standard procedures whereas minerals content by atomic absorption spectrophotometry. The crude protein content was in the range of 20.69–23.08 %, crude fat, 0.59–1.14 %, crude fibre, 4.06–6.86 %, ash, 4.39–5.61%, moisture 9.19-11.83 %, carbohydrate 54.31-59.64 % and energy, 313.28-328.10 kcal/100 g. The mineral content was in the range of 2.45–172.77 mg/100g, for Iron and Phosphorus respectively. The functional properties of the flours: foaming capacity, solubility capacity, bulk density, swelling index, water absorption capacity, and emulsion capacity were in the range of 18.00-22.13%, 17.00-21.01%, 0.66 g/mL, 0.98-1.64, 0.88-1.41 g/g, and 49.63-59.99%, respectively. The results indicate that, lima beans are rich in protein and have appreciable functional properties that could be exploited in food formulations such as koose, sauces and stews. The lima bean flours could also be used to fortify conventional flours which are low in protein and fiber.
Distinctive Combinations of RBD Mutations Contribute to Antibody Evasion in the Case of the SARS-CoV-2 Beta Variant

Since its first report in 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has posed a grave threat to public health. Virus-specific countermeasures, such as vaccines and therapeutics, have been developed and have contributed to the control of the viral pandemic, which has become endemic. Nonetheless, new variants continue to emerge and could cause a new pandemic. Consequently, it is important to comprehensively understand viral evolution and the roles of mutations in viral infectivity and transmission. SARS-CoV-2 beta variant encode mutations (D614G, N501Y, E484K, and K417N) in the spike which are frequently found in other variants as well. While their individual role in viral infectivity has been elucidated against various therapeutic antibodies, it still remains unclear whether those mutations may act additively or synergistically when combined. Here, we report that N501Y mutation shows differential effect on two therapeutic antibodies tested. Interestingly, the relative importance of E484K and K417N mutations in antibody evasion varies depending on the antibody type. Collectively, these findings suggest that continuous efforts to develop effective antibody therapeutics and combinatorial treatment with multiple antibodies are more rational and effective forms of treatment.
The effect of preinduction cervical length measurement with three different ultrasonographic methods on predicting delivery time

This study aimed to evaluate the effect of preinduction cervical length (CL) measurement by transvaginal (TV), transperineal (TP), and transabdominal (TA) ultrasonography (USG) on the time of delivery and to compare these three sonographic methods in terms of superiority over one another.