Miracle-dz/UniFAR-FTUs huggingface dataset:
Residual Tuning: Toward Novel Category Discovery Without Labels

Discovering novel visual categories from a set of unlabeled images is a crucial and essential capability for intelligent vision systems since it enables them to automatically learn new concepts with no need for human-annotated supervision anymore. To tackle this problem, existing approaches first pretrain a neural network with a set of labeled images and then fine-tune the network to cluster unlabeled images into a few categorical groups. However, their unified feature representation hits a tradeoff bottleneck between feature preservation on labeled data and feature adaptation on unlabeled data. To circumvent this bottleneck, we propose a residual-tuning approach, which estimates a new residual feature from the pretrained network and adds it with a previous basic feature to compute the clustering objective together. Our disentangled representation approach facilitates adjusting visual representations for unlabeled images and overcoming forgetting old knowledge acquired from labeled images, with no need of replaying the labeled images again. In addition, residual-tuning is an efficient solution, adding few parameters and consuming modest training time. Our results on three common benchmarks show consistent and considerable gains over other state-of-the-art methods, and further reduce the performance gap to the fully supervised learning setup. Moreover, we explore two extended scenarios, including using fewer labeled classes and continually discovering more unlabeled sets, where the results further signify the advantages and effectiveness of our residual-tuning approach against previous approaches. Our code is available at https://github.com/liuyudut/ResTune.
Anterior–posterior pattern formation in ciliates

As single cells, ciliates build, duplicate, and even regenerate complex cortical patterns by largely unknown mechanisms that precisely position organelles along two cell‐wide axes: anterior–posterior and circumferential (left–right). We review our current understanding of intracellular patterning along the anterior–posterior axis in ciliates, with emphasis on how the new pattern emerges during cell division. We focus on the recent progress at the molecular level that has been driven by the discovery of genes whose mutations cause organelle positioning defects in the model ciliate Tetrahymena thermophila. These investigations have revealed a network of highly conserved kinases that are confined to either anterior or posterior domains in the cell cortex. These pattern‐regulating kinases create zones of cortical inhibition that by exclusion determine the precise placement of organelles. We discuss observations and models derived from classical microsurgical experiments in large ciliates (including Stentor) and interpret them in light of recent molecular findings in Tetrahymena. In particular, we address the involvement of intracellular gradients as vehicles for positioning organelles along the anterior‐posterior axis.
Development and Validation of a Treatment Benefit Index to Identify Hospitalized Patients With COVID-19 Who May Benefit From Convalescent Plasma

Key Points Question What patient characteristics are associated with benefit from treatment with COVID-19 convalescent plasma (CCP)? Findings This prognostic study of 2287 patients hospitalized with COVID-19 identified a combination of baseline characteristics that predict a gradation of benefit from CCP compared with treatment without CCP. Preexisting health conditions (diabetes, cardiovascular and pulmonary diseases), blood type A or AB, and earlier stage of COVID-19 were associated with a larger treatment benefit. Meaning These findings suggest that simple patient information collected at hospitalization can be used to guide CCP treatment decisions for patients with COVID-19.
Broccoli-liked silver phosphate nanoparticles supported on green nanofiber membrane for visible-light driven photodegradation towards water pollutants

In view of the practical application, it is imperative to develop efficient, exercisable, and visible light driven water pollution treatment materials. Herein, a high-efficiency green photocatalytic membrane for water pollution treatment is proposed and fabricated conveniently. Firstly, silver phosphate (Ag3PO4) nanoparticles with controlled morphology were prepared by simple liquid-phase precipitation method, and then a hierarchical structured Ag3PO4@polylactic acid (PLA) composite nanofiber membrane was prepared by electrospinning. Using electrospun PLA nanofiber membrane as a carrier of photocatalysts can significantly improve the dispersion of Ag3PO4 nanoparticles, and increase the contact probability with pollutants and photocatalytic activity. The prepared PLA@Ag3PO4 composite membrane was used to degrade methylene blue (MB) and tetracycline hydrochloride (TC) under visible light irradiation. The results showed that the removal ratio of pollutants on Ag3PO4@PLA composite nanofiber membrane was 94.0% for MB and 82.0% for TC, demonstrating an outstanding photocatalytic activity of composite membrane. Moreover, the PLA nanofiber membrane is a self-supported and biodegradable matrix. After five cycles, it can still achieve 88.0% of the initial photocatalytic degradation rate towards MB, showing excellent recyclability. Thus, this composite nanofiber membrane is a high-efficiency and environmental-friendly visible light driven water pollution treatment material that could be used in real applications.
Effects of electroconvulsive therapy on nitrosative stress and oxidative DNA damage parameters in patients with a depressive episode

Abstract Background Few studies have investigated the relationship between electroconvulsive therapy (ECT) and markers of nitrosative stress and oxidative DNA damage. Objective The aim of this study is to examine changes in nitrosative stress and oxidative DNA damage in patients with a depressive episode treated with ECT. Methods The current study included 48 patients with a depressive episode treated with ECT and 30 healthy control participants. First, the serum nitrosative stress markers of nitric oxide (NO•), nitric oxide synthase (NOS), and peroxynitrite (ONOO-) and the oxidative DNA damage marker 8-hydroxy-2′-deoxyguanosine (8-OHdG) were compared between the study and control groups. These parameters were also compared pre- and post-treatment for the study group. Results NO•, NOS, and ONOO- levels were significantly higher in patients with depressive disorder (DD) than in the control group. NO• and NOS levels significantly decreased in the ECT group after treatment while 8-OHdG levels significantly increased. Conclusions The study findings suggest that ECT may have reduced nitrosative stress levels while increasing oxidative DNA damage. More research is now needed to better understand the issue. KEY POINTS Nitrosative stress levels can increase in patients with depressive disorder. Electroconvulsive therapy may reduce nitrosative stress while increasıng oxidative DNA damage. These results suggest that nitrosative stress plays an important role in the mechanism of action of electroconvulsive therapy.
Effects of Greek Honey and Propolis on Oxidative Stress and Biochemical Parameters in Regular Blood Donors

Abstract Background and objectives: Honey products contain a lot of compounds, such as vitamins, enzymes, and minerals, which make honey and its products a great antioxidant with a critical role in health status. It is well accepted that honey and propolis can improve a lot of health problems when they are consumed in certain quantities. The objective of this study is to help regular blood donors improve their health status after donation. Material and methods: Eighty regular blood donor volunteers—30 males aged 19–61 and 30 females aged 21–64—were divided into 4 groups: group A (n = 20) consumed 2 spoons of Greek honey and 1 drop of propolis per day for 1 month, group B (n = 20) consumed 2 spoons of honey per day for 1 month, group C (n = 20) consumed 1 drop of propolis per day, and group D (n = 20) did not consume any Greek honey products. Blood samples were collected from all participants just before the consumption of the products, one month after the consumption, and six months after honey product consumption had ceased. All samples were analyzed for reactive oxygen species (ROS), lipid profiles, and ferritin levels. Results: The ROS were significantly (p < 0.05) lower in groups A, B, and C after the honey product consumption and increased significantly again after six months. No significant differences in lipid profiles were observed. Only triglyceride levels were increased after six months in all groups. On the other hand, ferritin levels were not statistically significantly decreased after six months in groups A and B, while they were increased in group C. Conclusions: In the present study, statistically significant decreases in ROS status was found after a small dose of honey product consumption, indicating a diet with an extra small dose of honey products after blood donation.
Preterm labor tests: current status and future directions

Abstract Preterm labor (PTL) is a severe issue of neonatal healthcare because its related to preterm birth (PTB) is the leading cause of neonatal mortality and the most common reason for antenatal hospitalizations. The PTB rate is about 11% globally and it is similar in the United States. PTB poses a significant economic burden on the healthcare system. Early diagnosis of PTL is the key to reducing PTB rate, neonatal mortality, and long-term neurological impairment in children. The diagnosis of PTL is usually based on clinical criteria, but the accuracy of the diagnosis is poor. To predict the risk of PTL more accurately, tests of biomarkers with variable clinical diagnostic performances have been developed and some of them have been applied clinically. In this article, we analyze the performance characteristics of these biomarkers, such as sensitivity, specificity, positive predictive value, and negative predictive value, as well as the clinical utility of current biomarkers so that clinical laboratorians and clinicians can better understand the limitations of these tests and utilize them wisely. We also summarize the current recommendations on clinical utilization of PTL biomarkers. Finally, we explore the prospects of future omics-based novel biomarkers, which may improve prediction of PTL in the future.
Overview of epidemiological characteristics, clinical features, and risk factors of gastric cancer in Asia‐Pacific region

In spite of decreasing the overall incidence of gastric cancer (GC), it remains one of the most common and deadly cancers worldwide. The incidence and mortality rate of GC is very different in the world. Geographical differentiation is one of the most distinctive characteristics of GC. Effective prevention and early diagnostic strategies are the most important public health interventions in GC, as a common malignancy worldwide. Notably, the preventive strategies require understanding the risk factors associated with GC for identifying high‐risk groups that may require screening for prevention. Therefore, up‐to‐date statistics on GC occurrence and outcome are essential for the primary prevention of the disease. We conducted this review based on the current epidemiology knowledge of GC to provide an update perspective of GC in Asia‐Pacific region. Based on the findings of this study, incidence and mortality rate of GC in Asia‐Pacific region shows a great heterogeneity. Gastric carcinogenesis arises as a consequence of a complex interaction between host and environmental factors. In addition to screening and eradication of Helicobacter pylori (H. pylori) infection, it seems that the main cause of GC is an undesirable lifestyle in this region. Therefore, it is necessary to improve the lifestyle and the community awareness about GC risk factors and healthy lifestyle education.
Cost-effectiveness analysis on implementing newborn hearing screening programmes in a low- to middle-income country

Abstract Objective To analyse the cost-effectiveness (CE) of implementing different newborn hearing screening protocols in a low- to middle-income country. Design A decision analytical model with a 78-year time horizon. Study sample Direct medical, direct non-medical and indirect costs were collected from 126 subjects in southern Thailand. Various protocols involving universal newborn hearing screening (UNHS) and targeted newborn hearing screening (TNHS), using two technologies, namely automated otoacoustic emissions (aOAEs) and automated auditory brainstem responses (aABRs), were evaluated. Incremental cost-effectiveness ratios (ICERs) were calculated for all protocols in United States dollars (US$)/quality-adjusted life year (QALY) gained. Also, probabilistic sensitivity analyses with 1000 trials for each specific protocol were performed. Results The ICERs of UNHS with aOAE, UNHS with aABR, TNHS with aABR and UNHS with optimised baseline parameters were 3702, 3545, 1545 and 2483 US$/QALY gained, respectively. With the CE threshold of 5000 US$/QALY gained, the chances of ICERs to be cost-effective for UNHS with aOAE, UNHS with aABR, TNHS with aABR and UNHS with optimised baseline parameters were 72, 77, 93 and 94%, respectively. Conclusions All screening protocols were considered as cost-effective, and a very high chance of being cost-effective for UNHS could be achieved when certain baseline parameters were optimised.
Effect of antibiotic prophylaxis in dental implant surgery: A multicenter placebo‐controlled double‐blinded randomized clinical trial

Abstract Background The growing resistance of bacteria to antimicrobial medicines is a global issue and a direct threat to human health. Despite this, antibiotic prophylaxis is often still routinely used in dental implant surgery to prevent bacterial infection and early implant failure, despite unclear benefits. There is a lack of sufficient evidence to formulate clear clinical guidelines and therefore there is a need for well‐designed, large‐scale randomized controlled trials to determine the effect of antibiotic prophylaxis. Purpose To compare the effect of a presurgical antibiotic regimen with an identical placebo regimen in healthy or relatively healthy patients receiving dental implants. Materials and Methods The 474 patients participating in the study were recruited from seven clinics in southern Sweden. We randomized the patients into a test and a placebo group; the study was conducted double‐blinded. Preoperatively, the test group received 2 g of amoxicillin and the control group, identical placebo tablets. The primary outcome was implant failure; secondary outcomes were postoperative infections and adverse events. Patients were evaluated at two follow‐ups: at 7–14 days and at 3–6 months. Results Postoperative evaluations of the antibiotic (n = 238) and the placebo (n = 235) groups noted implant failures (antibiotic group: six patients, 2.5% and placebo group: seven patients, 3.0%) and postoperative infections (antibiotic group: two patients, 0.8% and placebo group: five patients, 2.1%). No patient reported any adverse events. Between‐group differences in implant failures and postoperative infections were nonsignificant. Conclusion Antibiotic prophylaxis in conjunction with implant placement is likely of small benefit and should thus be avoided in most cases, especially given the unabated growth in antibiotic‐resistant bacteria. Clinical trial registration number: NCT03412305.
In Reply.

ulator-guided sciatic nerve block at the popliteal fossa. Br J Anaesth 2009; 102:855– 61 5. Robards C, Hadzic A, Somasundaram L, Iwata T, Gadsden J, Xu D, Sala-Blanch X: Intraneural injection with low-current stimulation during popliteal sciatic nerve block. Anesth Analg 2009; 109:673–7 6. Tran de QH, Dugani S, Pham K, Al-Shaafi A, Finlayson RJ: A randomized comparison between subepineural and conventional ultrasound-guided popliteal sciatic nerve block. Reg Anesth Pain Med 2011; 36:548 –52 7. Sala-Blanch X, De Riva N, Carrera A, López AM, Prats A, Hadzic A: Ultrasound-guided popliteal sciatic block with single injection at the sciatic division results in faster block onset than classical nerve stimulator technique. Anesth Analg; 2012 (in press) 8. Bigeleisen PE, Moayeri N, Groen GJ: Extraneural versus intraneural stimulation thresholds during ultrasound-guided supraclavicular block. ANESTHESIOLOGY 2009; 110:1235– 43 9. Sala-Blanch X, Vandepitte C, Laur JJ, Horan P, Xu D, Reina MA, Karmakar MK, Clark TB, Hadzic A: A practical review of perineural versus intraneural injections; A call for standard nomenclature. Int Anesthesiol Clin 2011; 49:1–12 10. Borgeat A, Aguirre J: Assessment and treatment of postblock neurologic injury. Anesthesiol Clin 2011; 29:243–56 11. Albrecht E, Niederhauser J, Gronchi F, Löcherbach C, Kombot C, Rossat J, Gilliard N, Kuntzer T: Transient femoral neuropathy after knee ligament reconstruction and nerve stimulator-guided continuous femoral nerve block: A case series. Anaesthesia 2011; 66:850 –1
Elastodynamics Analysis of Cam Mechanism Based on ADAMS

A analysis method is proposed considering the dynamic effect of elastic component for high speed cam mechanism.An elastodynamics model is constructed using ADAMS,and the motion law is analyzed.The rigid-flexible coupling model of the cam mechanism is built using ADAMS/Flex based on corrected Craig-Bampton method and I-DEAS generating Modal Neutral File(MNF). By comparing the cam mechanism dynamics characteristics with different stiffness of the cam carrier,the corresponding curve of the follower is obtained,which provides a design basis for the elastic cam mechanism.
Comparison of quantitative susceptibility mapping methods on evaluating radiation‐induced cerebral microbleeds and basal ganglia at 3T and 7T

Quantitative susceptibility mapping (QSM) has the potential for being a biomarker for various diseases because of its ability to measure tissue susceptibility related to iron deposition, myelin, and hemorrhage from the phase signal of a T2*‐weighted MRI. Despite its promise as a quantitative marker, QSM is faced with many challenges, including its dependence on preprocessing of the raw phase data, the relatively weak tissue signal, and the inherently ill posed relationship between the magnetic dipole and measured phase. The goal of this study was to evaluate the effects of background field removal and dipole inversion algorithms on noise characteristics, image uniformity, and structural contrast for cerebral microbleed (CMB) quantification at both 3T and 7T. We selected four widely used background phase removal and five dipole field inversion algorithms for QSM and applied them to volunteers and patients with CMBs, who were scanned at two different field strengths, with ground truth QSM reference calculated using multiple orientation scans. 7T MRI provided QSM images with lower noise than did 3T MRI. QSIP and VSHARP + iLSQR achieved the highest white matter homogeneity and vein contrast, with QSIP also providing the highest CMB contrast. Compared with ground truth COSMOS QSM images, overall good correlations between susceptibility values of dipole inversion algorithms and the COSMOS reference were observed in basal ganglia regions, with VSHARP + iLSQR achieving the susceptibility values most similar to COSMOS across all regions. This study can provide guidance for selecting the most appropriate QSM processing pipeline based on the application of interest and scanner field strength.
Influence of reducing starch in the diets with similar protein and energy contents on lactation performance, ruminal fermentation, digestibility, behaviour and blood metabolites in primiparous and multiparous dairy cows

Abstract Background It is not clearly known whether parity can affect the outcomes of starch reduction in the diet of lactating dairy cows. Introduction A 2 × 2 factorial study was conducted to evaluate the effects of reducing starch in the diets with similar protein and energy contents on lactation performance, ruminal fermentation, nutrient digestibility, behaviour and blood metabolites in primiparous (PP) and multiparous (MP) dairy cows. Methods Twenty PP cows (DIM = 37 ± 10; 40 ± 5 kg/day of milk; mean ± SD) and 20 MP cows (DIM = 37 ± 9; 48 ± 5 kg/day of milk) were used in present study. Treatments were a factorial arrangement of two levels of starch (high vs. low) and two parity categories (PP vs. MP): (1) high‐starch diet (29.2% ± 0.70) and PP cows (HS‐PP); (2) low‐starch diet (22.3% ± 0.52) and PP cows (LS‐PP); (3) high‐starch diet and MP cows (HS‐MP) and (4) low‐starch diet and MP cows (LS‐MP). All diets were formulated to be similar in crude protein (16.1 % of dry matter) and NEL (1.60 Mcal/kg of dry matter) contents. The amount of metabolise protein was 2688 g/day in high‐starch diet and 2728 g/day in low‐starch diet. The experiment was conducted over two consecutive periods and included 4 weeks for adaptation and 3 weeks for data collection. Results Dry matter intake and the yield of milk true protein and lactose increased but milk fat: protein ratio and nutrient digestibility decreased for cows fed the HS diets compared with the LS diets. The ruminal proportion of propionate was greater but acetate, the acetate to propionate ratio and sorting against long particles (19 and 8 mm) were lower for cows fed the HS diets than the LS diets. Multiparous cows had a greater nutrient intake and milk yield, longer rumination meal length, greater BW, but lower plasma total antioxidant capacity, non‐esterified fatty acids, faeces pH compared with PP cows. An interaction between parity and the dietary level of starch was detected on feed efficiency measured as FCM yield/DMI in the way that only within PP cows low‐starch diet was more efficient than HS diets. We found another interaction effect of parity × starch on back fat thickens (BFT) change in the way that only within PP cows BFT change was greater for HS compared with LS diet. Conclusion Overall, regardless of the benefit derived from feeding a reduced‐starch diet by partially replacing grains with sugar beet pulp in the diets on nutrient digestibility, a reduced‐starch diet may be used more efficiently in PP than in MP cows but at expense of body reserves (i.e. BFT) loses.
The promiscuous and highly mobile resistome of Acinetobacter baumannii

Antimicrobial resistance (AR) is a major global threat to public health. Understanding the population dynamics of AR is critical to restrain and control this issue. However, no study has provided a global picture of the whole resistome of Acinetobacter baumannii , a very important nosocomial pathogen. Here we analyse 1450+ genomes (covering >40 countries and >4 decades) to infer the global population dynamics of the resistome of this species. We show that gene flow and horizontal transfer have driven the dissemination of AR genes in A. baumannii . We found considerable variation in AR gene content across lineages. Although the individual AR gene histories have been affected by recombination, the AR gene content has been shaped by the phylogeny. Furthermore, many AR genes have been transferred to other well-known pathogens, such as Pseudomonas aeruginosa or Klebsiella pneumoniae . Despite using this massive data set, we were not able to sample the whole diversity of AR genes, which suggests that this species has an open resistome. Our results highlight the high mobilization risk of AR genes between important pathogens. On a broader perspective, this study gives a framework for an emerging perspective (resistome-centric) on the genomic epidemiology (and surveillance) of bacterial pathogens.