Miracle-dz/UniFAR-FTUs huggingface dataset:
Asexuality: a content analysis of sex therapy journals

ABSTRACT Despite recent progress in society’s understanding of sexuality as a nuanced, highly individualised concept, asexuality is a continually under-researched and misunderstood sexual identity and community. Via content analysis, the authors examined 41 publications in nine leading journals in the sex therapy field to assess how asexuality has been represented in literature over the past decade. The purpose of the review was to determine if this literature acknowledges the spectrum of asexual identities, whether asexuality and aromanticism are conflated terms, and whether asexuality is pathologized. The review determined that 41.5% of publications did not note the heterogeneity of identities under the asexuality umbrella, 12.2% conflated the terms asexuality and aromanticism, and 0% pathologized asexuality. Implications are discussed.
Flexible Skin for Flight Parameter Estimation Based on Pressure and Velocity Data Fusion

Accurate perception of flight parameters is essential for the safe and stable flight of small unmanned aerial systems (SUASs). However, traditional flush air data sensing (FADS) systems require complex tubing and fuselage openings. Herein this study, a flexible skin system integrated with a pressure and thermal flow sensor array, and a dual‐sensor fusion algorithm for determining the angle of attack (AOA) and airspeed (V ∞ ), are proposed. By establishing an error back‐propagation neural network, the dual‐sensor fusion modality demonstrates higher estimation accuracy than other modalities that utilize only pressure data or only flow velocity data, achieving mean absolute errors of the AOA and V ∞ of less than 0.16° and 0.37 ms−1, respectively. Moreover, the simulation and experimental results show that sensors placed closer to the leading edge of the wing can provide higher estimation accuracy of the flight parameters. The flight parameters determined using the flexible air data sensing system and dual‐sensor fusion algorithm demonstrate potential application in the flight control of SUASs.
The dawn of the flying reptiles: first Triassic record in the southern hemisphere

Pterosaurs were the first vertebrates to evolve powered flight. The timing of their origin is still debated, and hypotheses range from the end of the Permian Period, to the lower Mesozoic Era, and through to the Middle–Late Triassic epochs. Regardless of when they originated, the oldest records are restricted to the Upper Triassic Norian Stage in the northern hemisphere (Europe, USA and Greenland). We report two new raeticodactylid pterosaurs, Yelaphomte praderioi gen. et sp. nov. and Pachagnathus benitoi gen. et sp. nov. from the upper Norian to Rhaetian Quebrada del Barro Formation in north‐western Argentina. The new specimens (an isolated dentary symphysis, partial rostrum, and distal half of ulna) are the first unequivocal Triassic records of pterosaurs in the southern hemisphere, confirming that the absence of pterosaurs outside north‐western Pangaea during the Late Triassic was the result of poor sampling rather than true absence. These new discoveries provide evidence of a greater diversity of pterosaurs living in terrestrial habitats and a wider global distribution of pterosaurs from the beginning of their evolution on Earth.
Increased Risk of Acute Lymphoblastic Leukemia in Adult Patients with GSTM1 Null Genetic Polymorphism

Purpose Glutathione S-transferases (GSTT1 and GSTM1) detoxify various endogenous and exogenous compounds and provide cytoprotective role against reactive species. This study aimed to assess the frequency of GSTT1, and GSTM1 polymorphisms in newly diagnosed Sudanese adult patients with acute lymphoblastic leukemia (ALL) and to evaluate the association of these polymorphisms with age, gender and type of ALL. Patients and Methods This case–control study included 128 adult Sudanese, untreated newly diagnosed patients with ALL, aged 18 to 74 years and 128 age-gender matched healthy controls. Deletional polymorphisms of GSTT1 and GSTM1 genes were genotyped through a multiplex polymerase chain reaction (PCR) assay using β-globin gene as an internal positive control. Results The genotypic frequency of GSTT1 null polymorphism was 22.7% in cases and 14.8% in controls (OR = 1.68, P = 0.111). Statistically significant differences were noted in the frequencies of GSTM1 null polymorphism in cases and controls (OR = 3.7, P = <0.001). Combined GSTT1 null and GSTM1 null gene polymorphisms showed statistically significant difference in patients with ALL as compared to controls (OR = 6.5, CI 95% = 1.42–29.74, P < 0.001). Conclusion Irrespective of age at diagnosis, gender, and phenotype of ALL, GSTM1 null polymorphism either alone or in combination with GSTT1 null polymorphism poses significantly increased risk of developing ALL in adults.
Alternative education needs in Oman: accommodating learning diversity and meeting market demand

Abstract The gap between educational outcomes and labour market demand is one of the most important issues concerning researchers and specialists in the field of educational planning and policy-making. Innovation, entrepreneurship, diversity and creativity characterize the globalized, high-tech labour markets. Whilst striving for a sustainable future, Oman is still grappling with entrenched, traditional methods of education. These educational methods are incapable of meeting diverse learning needs or producing young people, equipped to readily take their places in the workforce. Structured interviews with key figures in Oman were conducted to gauge the prospect of a vision of education which encompasses alternative schools, programmes and pathways to enhance opportunities for all students and facilitate outcomes that better match demands created by an increasingly sophisticated working environment. This paper is produced at a time when planning is underway for Vision 2040 and provides insight into the challenges and opportunities for alternative education in Oman.
How habitat selection, succession, and assembly rules can influence landscape ecology in natural and disturbed areas

Why should one find a particular set of small mammals at any particular site? This question is at the heart of community ecology, and while no definitive and conclusive answer can yet be provided, this paper does summarize a body of research that has explored, and I think clarified, some of the factors that influence which species occur where and when. The impacts of disturbances such as wildfire and sand mining are examined, along with the regeneration of vegetation and recolonization by small mammals that follow such disturbances in heathland and eucalypt forest in coastal eastern Australia. I describe results from experiments that confirm that these small mammal species do indeed choose or select habitats, rather than just make use of the habitats that are available. Further replicated, experimental removals, as manipulations of each species, one at a time, confirm that interspecific competition between these small mammal species is an important factor determining which species are found where and when, if the temporal aspect of succession is included. Guild assembly rules are examined to illustrate how they may determine which species may or may not become part of a community. Here, my review and synthesis illustrate how the major influences upon the community and landscape ecology of small mammals in the area examined are both spatially variable and temporally dynamic.
Using a linear-threshold model to investigate the genetic relationship between survival and productive traits in Japanese quail

Abstract The main goal of breeding programmes is to maximise the genetic improvement of the economic traits of farm animals. Beside the economic traits, the birds’ survival has directly influenced on the economic gain. Therefore, this study aimed to investigate the genetic relationship between survival and productive traits in Japanese quail. A total of 1854 records were collected during four generations from 2017 to 2019 in Khorasan Razavi Agricultural Research and Training Centre (KRARTC). Data were used to estimate the genetic correlations among quail survival (S) with egg weight (EW) and body weight gain (BWG) traits. Linear-threshold model was used to estimate (co)variance components, and genetic parameters of traits via the Gibbs sampling method. The heritability of EW was 0.04, and the heritability estimates for survival at different ages ranged from 0.138 to 0.399 in joint analysis with EW. The highest negative genetic correlation between EW and S0–14 (i.e. survival up to 14 d) was obtained as −0.704. The highest and lowest heritability of weight gain traits for BWG0–7 and BWG7–14 were 0.583 and 0.116, respectively. The analyses of BWG traits with survival at different ages revealed that the genetic correlations ranged from 0.015 (between BWG0–7 and S0–14) to 0.638 (between BWG0–7 and S0–7). This study showed that the genetic selection for survival at different ages could be effective. On the other hand, selection for BWG0–7 could also indirectly improve the survival in quails because of the positive and high genetic correlation between BWG0–7 with S0–7. Highlights Genetic improvement of production traits in quail may lead to reduced survival in quail. Studies regarding on the survival of quail were yet not carried out. Heritability of the survival at different ages showed that genetic selection for this trait could improve the survival. Survival at different ages had a negative genetic correlation with egg weight (EW), and body weight gain (BWG) traits after 21 d of old.
Noninvasive Assessment of Liver Fibrosis with ElastPQ in Patients with Chronic Viral Hepatitis: Comparison Using Histopathological Findings

Chronic viral hepatitis is a major cause of chronic liver disease leading to liver fibrosis. This study aimed to assess the diagnostic performance of elastography point quantification (ElastPQ), transient elastography (TE), and aspartate aminotransferase-to-platelet count ratio index (APRI) for the staging of liver fibrosis in patients with chronic viral hepatitis using histopathological findings as a reference standard. For 122 patients with chronic viral hepatitis, diagnostic performance was evaluated using area under the receiver operating characteristic curve (AUROC) analysis and correlations were determined using Spearman’s correlation coefficient. The AUROC of ElastPQ for the diagnosis of the fibrosis stage ≥ F2 was 0.917 with a cut-off value of 3.935. There was a significant positive correlation between the different stages of histologic liver fibrosis and stiffness values obtained using ElastPQ, TE, and APRI (ρ = 0.556, ρ = 0.657, ρ = 0.375, respectively; p < 0.001). ElastPQ showed a higher diagnostic accuracy than APRI, resembling that of TE; AUROC values of ElastPQ, TE, and APRI were 0.917, 0.964, and 0.896, respectively, for a fibrosis stage ≥ F2. ElastPQ is a promising noninvasive technique with a diagnostic accuracy comparable with that of TE for the evaluation of liver fibrosis in patients with chronic viral hepatitis.
NMR Spectroscopy Identifies Chemicals in Cigarette Smoke Condensate That Impair Skeletal Muscle Mitochondrial Function

Tobacco smoke-related diseases such as chronic obstructive pulmonary disease (COPD) are associated with high healthcare burden and mortality rates. Many COPD patients were reported to have muscle atrophy and weakness, with several studies suggesting intrinsic muscle mitochondrial impairment as a possible driver of this phenotype. Whereas much information has been learned about muscle pathology once a patient has COPD, little is known about how active tobacco smoking might impact skeletal muscle physiology or mitochondrial health. In this study, we examined the acute effects of cigarette smoke condensate (CSC) on muscle mitochondrial function and hypothesized that toxic chemicals present in CSC would impair mitochondrial respiratory function. Consistent with this hypothesis, we found that acute exposure of muscle mitochondria to CSC caused a dose-dependent decrease in skeletal muscle mitochondrial respiratory capacity. Next, we applied an analytical nuclear magnetic resonance (NMR)-based approach to identify 49 water-soluble and 12 lipid-soluble chemicals with high abundance in CSC. By using a chemical screening approach in the Seahorse XF96 analyzer, several CSC-chemicals, including nicotine, o-Cresol, phenylacetate, and decanoic acid, were found to impair ADP-stimulated respiration in murine muscle mitochondrial isolates significantly. Further to this, several chemicals, including nicotine, o-Cresol, quinoline, propylene glycol, myo-inositol, nitrosodimethylamine, niacinamide, decanoic acid, acrylonitrile, 2-naphthylamine, and arsenic acid, were found to significantly decrease the acceptor control ratio, an index of mitochondrial coupling efficiency.
The estrous cycle and 17β‐estradiol modulate the electrophysiological properties of rat nucleus accumbens core medium spiny neurons

The nucleus accumbens core is a key nexus within the mammalian brain for integrating the premotor and limbic systems and regulating important cognitive functions such as motivated behaviors. Nucleus accumbens core functions show sex differences and are sensitive to the presence of hormones such as 17β‐estradiol (estradiol) in normal and pathological contexts. The primary neuron type of the nucleus accumbens core, the medium spiny neuron (MSN), exhibits sex differences in both intrinsic excitability and glutamatergic excitatory synapse electrophysiological properties. Here, we provide a review of recent literature showing how estradiol modulates rat nucleus accumbens core MSN electrophysiology within the context of the estrous cycle. We review the changes in MSN electrophysiological properties across the estrous cycle and how these changes can be mimicked in response to exogenous estradiol exposure. We discuss in detail recent findings regarding how acute estradiol exposure rapidly modulates excitatory synapse properties in nucleus accumbens core but not caudate‐putamen MSNs, which mirror the natural changes seen across estrous cycle phases. These recent insights demonstrate the strong impact of sex‐specific estradiol action upon nucleus accumbens core neuron electrophysiology.
The Role of Brand Image to Mediate the Effect of Word of Mouth on the Intention of Using Wicitra Wedding Salon Services in the City of Denpasar

The increasing population in Bali greatly affects the need for wedding services. One of the wedding service companies in Bali is the Wicitra Wedding salon in Denpasar City. Wicitra Wedding Salon must carry out the right strategy so that consumers feel interested and have the intention of using the services of a Wicitra Wedding salon. The purpose of this study was to explain the role of brand image in mediating word of mouth (WOM) on intention to use. This research was conducted in Denpasar City. Samples were taken as many as 90 respondents through purposive sampling method and distributed using a google form questionnaire with adjusted criteria. Measured by 9 indicators and using a Likert scale. The data analysis technique used is path analysis and Sobel test. The results of this study indicate that all hypotheses are accepted. Word of mouth (WOM) has a positive and significant effect on intention to use. Word of mouth (WOM) has a positive and significant effect on brand image. Brand image has a positive and significant effect on intention to use. Brand image plays a significant role in mediating the effect of word of mouth (WOM) on intention to use. The results of this study indicate that in increasing the intention to use, the Wicitra Wedding salon is expected to always provide a strategy in the form of word of mouth (WOM) to touch the hearts of consumers and create a good brand image.
Recent Advances of Immune Checkpoint Inhibition and Potential for (Combined) TIGIT Blockade as a New Strategy for Malignant Pleural Mesothelioma

Malignant pleural mesothelioma (MPM) is a fatal cancer type that affects the membranes lining the lungs, and is causally associated with asbestos exposure. Until recently, the first-line treatment consisted of a combination of chemotherapeutics that only had a limited impact on survival, and had not been improved in decades. With the recent approval of combined immune checkpoint inhibition for MPM, promising new immunotherapeutic strategies are now emerging for this disease. In this review, we describe the current preclinical and clinical evidence of various immune checkpoint inhibitors in MPM. We will consider the advantages of combined immune checkpoint blockade in comparison with single agent checkpoint inhibitor drugs. Furthermore, recent evidence suggests a role for T cell immunoglobulin and ITIM domain (TIGIT), an inhibitory immunoreceptor, as a novel target for immunotherapy. As this novel immune checkpoint remains largely unexplored in mesothelioma, we will discuss the potential of TIGIT blockade as an alternative therapeutic approach for MPM. This review will emphasize the necessity for new and improved treatments for MPM, while highlighting the recent advances and future perspectives of combined immune checkpoint blockade, particularly aimed at PD-L1 and TIGIT.
A Novel Mechanism of Macrophage Activation by the Natural Yolkin Polypeptide Complex from Egg Yolk

Ageing is accompanied by the inevitable changes in the function of the immune system. It provides increased susceptibility to chronic infections that have a negative impact on the quality of life of older people. Therefore, rejuvenating the aged immunity has become an important research and therapeutic goal. Yolkin, a polypeptide complex isolated from hen egg yolks, possesses immunoregulatory and neuroprotective activity. Considering that macrophages play a key role in pathogen recognition and antigen presentation, we evaluated the impact of yolkin on the phenotype and function of mouse bone marrow-derived macrophages of the BMDM cell line. We determined yolkin bioavailability and the surface co-expression of CD80/CD86 using flow cytometry and IL-6, IL-10, TGF-β and iNOS mRNA expression via real-time PCR. Additionally, the impact of yolkin on the regulation of cytokine expression by MAPK and PI3K/Akt kinases was determined. The stimulation of cells with yolkin induced significant changes in cell morphology and an increase in CD80/CD86 expression. Using pharmaceutical inhibitors of ERK, JNK and PI3K/Akt, we have shown that yolkin is able to activate these kinases to control cytokine mRNA expression. Our results suggest that yolkin is a good regulator of macrophage activity, priming mainly the M1 phenotype. Therefore, it is believed that yolkin possesses significant therapeutic potential and represents a promising possibility for the development of novel immunomodulatory medicine.
Educational Attainment and Employment Outcome of Survivors of Pediatric CNS Tumors in Switzerland—A Report from the Swiss Childhood Cancer Survivor Study

Background: Childhood cancer survivors diagnosed with a central nervous system (CNS) tumor are at risk for educational and vocational challenges. This study compared educational attainment and employment outcome in survivors of CNS tumors to survivors of other malignancies. Methods: The questionnaire-based Swiss Childhood Cancer Survivor Study (SCCSS) included cancer patients diagnosed between 1976 and 2010, aged ≤20 years, who survived ≥5 years after diagnosis. We classified participants aged ≥16 years into three groups: CNS tumor and non-CNS malignancy with and without CNS-directed treatment. We analyzed educational attainment, employment outcome and special schooling. Subgroup analyses included survivors aged ≥25 years. Results: We analyzed 2154 survivors, including 329 (15%) CNS tumor survivors, 850 (40%) non-CNS tumor survivors with and 975 (45%) without CNS-directed treatment. Fewer CNS tumor survivors aged ≥25 years reached tertiary education (44%) compared to those without CNS-directed treatment (51%) but performed similar to survivors with CNS-directed treatment (42%). Among CNS tumor survivors, 36 (14%) received special schooling. Higher parental education was associated with higher levels in survivors. Employment outcome did not significantly differ between the three diagnostic groups. A higher proportion of CNS tumor survivors received disability pension or were unemployed. Conclusions: Our findings suggest that CNS tumor survivors need more time to achieve their highest educational level. This should influence clinical care of these survivors by offering vocational counseling.
Chloroplast genome structure and phylogenetic analysis of Juniperus chinensis

Abstract The chloroplast genome of Juniperus chinensis L. was assembled and annotated in this research. The size of the chloroplast genome is 127,811 bp. It contains a 91,322 bp large single-copy region and a 35,960 bp small single-copy region; it does not contain inverted repeats. The genome encodes 82 protein-encoding genes, 33 tRNAs, and four rRNAs. Phylogenetic analysis showed that J. chinensis was closer to congeneric species than those of Cupressaceae. These results provide a genomic basis for further evolutionary research on conifers.
Critical Evaluation of Thin Film Composite Membrane on Pesticide Removal

This study focuses on how operating pressure, pesticide characteristics, membrane materials, feed solution and draw solution affect the performance of thin film composite membranes on pesticides removal. The membrane separation discussed in this review involve nanofiltration (NF), reverse osmosis (RO) and forward osmosis processes (FO) (i.e., FO mode and pressure retarded osmosis (PRO) mode). High pressure shows positive effects on NF and RO membranes flux performances, but it could deform PRO membranes. Hydrophobic pesticides that are larger in size, negatively charged with small dipole moments will result in higher retention. Besides, ions in the feed solution increased the rejection efficiency and permeate flux of membrane whereas pesticides concentration has a negative effect on their retention. pH of feed solution determines the zeta potential of membrane. As for the draw solution, NaCl at higher concentration is recommended. This paper is crucial to give an overview on ways to improve the removal of pesticides with various thin film composite membranes.