Miracle-dz/UniFAR-FTUs huggingface dataset:
Stratification of Acute Kidney Injury Risk, Disease Severity, and Outcomes by Electrolyte Disturbances

Acute kidney injury (AKI) affects up to 30% of all hospitalized patients in Central Europe and the USA. New biomarker molecules have been identified in recent years; most studies performed so far however aimed to identify markers for diagnostic purposes. Serum electrolytes such as sodium and potassium are quantified in more or less all hospitalized patients. Aim of the article is to review the literature on the AKI predictive role of four distinct serum electrolytes in evolving/progressing AKI. The following databases were searched for references: PubMed, Web of Science, Cochrane Library, and Scopus. The period lasted from 2010 until 2022. The following terms were utilized: “AKI” AND “sodium” OR “potassium” OR “calcium” OR “phosphate” AND “risk” OR “dialysis” OR “recovery of kidney function” OR “renal recovery” OR “kidney recovery” OR “outcome”. Finally, 17 references were selected. The included studies were mostly retrospective in nature. Particularly, hyponatremia has been shown to be associated with an overall poor clinical outcome. The association between dysnatremia and AKI is anything but consistent. Hyperkalemia and potassium variability are most likely AKI predictive. Serum calcium and AKI risk are associated in a U-shaped manner. Higher phosphate levels potentially predict AKI in non-coronavirus disease 2019 (COVID-19) patients. The literature suggests that admission electrolytes can offer valuable information about AKI onset during follow-up. Limited data are however available on follow-up characteristics such as the need for dialysis or the chance of renal recovery. These aspects are of particular interest from the nephrologist’s perspective.
Multicultural education: Teachers’ perceptions in Hosanna College of Education, southern nations, nationalities, and peoples’ region (SNNPR), Ethiopia

Abstract This study was intended to explore how the perceptions of teachers affect multicultural education (MCE) in diversified classrooms at Hosanna College of Education. A descriptive textual narration with a qualitative case study and purposive sampling research design were employed in this study. Semi-structured interviews and document analysis were used to collect data. The respondents were teachers at Hosanna College of Education. The findings confirmed that the perceptions of teachers were positive toward the teaching of a diverse student population. This is to say that it was evident that teachers felt a desire to provide experiences for their students to help them understand cultural diversity. Inevitably, the study acknowledged that MCE is crucial for nation-wide integration through peace building and sustaining progressive development. However, teachers had no sufficient skills and motivation to investigate studies to encourage and promote MCE because of the reluctant commitment of the College administration. Due to the absence of a strategic plan and a lack of purposeful preparation and content selection for the modular curriculum, the dimensions of MCE were not applied and incorporated into the curriculum as required. As MCE and diversity are not yet meaningfully implemented, it is recommended that teachers, regional education bureaus, policymakers, and the MoE should play a decisive role in efficiently enhancing diversity and tackle the acute problems related to MCE.
Revisiting targeted therapy and immunotherapy for advanced cholangiocarcinoma

Cholangiocarcinoma (CCA) is a rare and aggressive type of malignant tumor. In the past few years, there has been an increase in the incidence of CCA. Surgery is the only effective treatment but is only suitable for a small percentage of patients. Comprehensive treatment is the normal therapy for terminal CCA patients, depending basically on gemcitabine and cisplatin combination chemotherapy. In the past decade, the emergence of next-generation sequencing technology can be used for the identification of important molecular features of CCA, and several studies have demonstrated that different CCA subtypes have unique genetic aberrations. Targeting fibroblast growth factor receptor (FGFR), isocitrate dehydrogenase (IDH) and epidermal growth factor receptor 2 (EGFR2) are emerging targeted therapies. In addition, researches have indicated that immunotherapy has a key function in CCA. There is ongoing research on programmed cell death protein 1 inhibitors (PD-1), chimeric antigen receptor T cells (CAR-T) and tumor-infiltrating leukocyte (TILs). Researches have shown that targeted therapy, immunotherapy, and conventional chemotherapy in CCA had certain mechanistic links, and the combination of those can greatly improve the prognosis of advanced CCA patients. This study aimed to review the research progress of targeted therapy and immunotherapy for CCA.
Dynamics of the shoulder and elbow joints of the throwing arm during a baseball pitch

Fastball pitches of eight intercollegiate varsity baseball pitchers were filmed using the direct linear transformation (DLT) method of three-dimensional cinematography. Coordinate data were obtained, and the resultant joint forces and torques at the shoulder and elbow joints were calculated. Various kinematic parameters were also calculated to help describe the motions of the shoulder and elbow joints throughout the pitch. At the instant of stride foot contact, a horizontal adduction torque was present at the shoulder joint, and the shoulder was externally rotating. After the onset of the horizontal adduction torque, abduction and internal rotation torques were also present at the shoulder joint and a varus torque was present at the elbow joint. After the instant of maximum external rotation (30 ms prior to ball release), the upper arm started to internally rotate, but it was still in a position of external rotation at the instant of release. This paper discusses the roles of the torques in producing the .
The THORPEX Observation Impact Intercomparison Experiment

Abstract An experiment is being conducted to directly compare the impact of all assimilated observations on short-range forecast errors in different forecast systems using an adjoint-based technique. The technique allows detailed comparison of observation impacts in terms of data type, location, satellite sounding channel, or other relevant attributes. This paper describes results for a “baseline” set of observations assimilated by three forecast systems for the month of January 2007. Despite differences in the assimilation algorithms and forecast models, the impacts of the major observation types are similar in each forecast system in a global sense. However, regional details and other aspects of the results can differ substantially. Large forecast error reductions are provided by satellite radiances, geostationary satellite winds, radiosondes, and commercial aircraft. Other observation types provide smaller impacts individually, but their combined impact is significant. Only a small majority of the tota.
Analysis of power spectra of Doppler shift time series as a diagnostic tool for quiescent coronal loops

Context. Analysing the structure of solar coronal loops is crucial to our understanding of the processes which heat and maintain the coronal plasma at multimillion degree temperatures. The determination of the physical parameters of the loops remains both an observational and theoretical challenge. Aims. The present work is aimed at tackling some of these challenges such as the determination of the average loop temperature and its distribution along a given loop. Methods. A novel diagnostic technique for quiescent coronal loops based on the analysis of power spectra of Doppler shift time series is proposed. It is assumed that the loop is heated randomly both in space and time by small-scale discrete impulsive events of unspecied nature. The loop evolution is characterized by longitudinal motions caused by the random heating events. These random motions can be represented as a superposition of the normal modes of the loop, i.e., its standing acoustic wave harmonics. The idea is borrowed from helioseismology where a similar approach resulted in a deep understanding of the solar interior. Results. It is shown that depending on the heliographic position of the loop and its geometrical orientation, various harmonics can be identied in the power spectra of the line shift time series. The highest power peak corresponds to the fundamental mode. The peaks become smaller as the frequency increases. The frequencies of the harmonics are determined by the loop length and temperature and thus are suggested to be used as a temperature diagnostic tool. It is demonstrated that the analysis of the power spectra allows the distinction between uniformly heated loops from loops heated near their foot-points and to estimate the average energy of a single heating event. The proposed new method could in principle be used to study the multi-thermal structure of coronal loops. Conclusions. The power spectrum analysis is a potentially powerful technique for coronal loop diagnostics.
Blowup of smooth solutions to the compressible Navier‐Stokes equation with compact density

We present a sufficient condition on the blowup of smooth solutions to the compressible Navier-Stokes equations in arbitrary space dimensions with initial density of compact support. As an immediate application, it is shown that any smooth solutions to the compressible Navier-Stokes equations for polytropic fluids in the absence of heat conduction will blow up in finite time as long as the initial densities have compact support, and an upper bound, which depends only on the initial data, on the blowup time follows from our elementary analysis immediately. Another implication is that there is no global small (decay in time) or even bounded (in the case that all the viscosity coefficients are positive) smooth solutions to the compressible Navier-Stokes equations for polytropic fluids, no matter how small the initial data are, as long as the initial density is of compact support. This is in contrast to the classical theory of global existence of small solutions to the same system with initial data being a small perturbation of a constant state that is not a vacuum. The blowup of smooth solutions to the compressible Euler system with initial density and velocity of compact support is a simple consequence of our argument. © 1998 John Wiley & Sons, Inc.
ANTIMICROBIAL ACTIVITY, ALONE AND IN CONJUNCTION WITH CEFUROXIME

Introduction: Occurrence of multidrug resistant microorganism is the result of irrational use of antibiotics. Recently essential oil, an important constituent of therapeutic and scented plant has been explored for their antimicrobial activity. Objectives: In this study, antibacterial activities of rosemary essential oil (REO) alone and also in conjunction with beta lactam antibiotic cefuroxime (CXM) were assessed. The purity of REO was checked by gas chromatography / mass spectrophotometry method (GC-MS). Methodology: By agar well diffusion method for REO and its diluents with dimethyl sulfoxide (DMSO) and tween 80, the zone of inhibition (ZOI) against four Gram positive bacterial strains of Bacillus subtilis, Bacillus cereus, Staphylococcus aureus, and Staphylococcus epidermidis and three Gram negative bacterial strains of Pseudomonas aeruginosa (1:2,1:10, 1:20, 1:40 and 1:50). E. coli as bacterial and DMSO as solvent were used as a control. Results: Antimicrobial activity was found to be highest against Staphylococcus aureus with ZOI 17.56mm and the lowest against Pseudomonas aeruginosa with ZOI 5.53 mm. The combination of REO and CXM indicated synergistic effects against E. coli, Staphylococcus aureus, Klebsiella pneumonia and Proteus mirabilis and antagonistic effect against Pseudomonas aeruginosa and indifferent effects against Bacillus subtilis and bacillus epidermidis based on fractional inhibitory concentration (FIC) values. The t test was applied to FIC values that showed significant p value (< 0.5). Conclusion: In conclusion, the antibacterial activity of the REO and CXM was enhanced when administered in combination, with the exception of Pseudomonas aeruginosa. In future this study may lead the way to the development of new drug combinations and dosage forms for increased antimicrobial and a reduced resistance against common pathogens.
Study on the correlation between microbial communities with physicochemical properties and flavor substances in the Xiasha round of cave-brewed sauce-flavor Baijiu

The Chishui River basin is the main production area of the sauce-flavor Baijiu. Due to the particularity of sauce-flavor Baijiu technology, a large site of workshops needs to be built for brewing and storage. Therefore, used the natural karst caves of Guizhou province to manufacture the sauce-flavor Baijiu, which has enriched the connotation of sauce-flavor Baijiu and saved valuable land resources. In this study, the fermentation grains in the seven stages during the Xiasha round of the cave-brewed sauce-flavor Baijiu (CBSB) were detected using a combination of physicochemical analysis, Headspace solid-phase microextraction gas chromatography-mass detection, and Illumina HiSeq sequencing methods. The results showed Unspecified_Leuconostocaceae, Weissella, Unspecified_Bacillaceae, Saccharomycopsis, Thermomyces, and Unspecified_Phaffomycetaceae were the main bacterial and fungal genera in the stacking fermentation (SF). In the cellar fermentation (CF), the Lactobacillus, Unspecified_Lactobacillaceae, Thermoactinomyces, Saccharomycopsis, Unspecified_Phaffomycetaceae, and Wickerhamomyces were the main bacterial and fungal genera. A total of 72 volatiles were detected in the fermented grains. Linear discriminant analysis Effect Size (LEfSe) identified 23 significantly different volatile metabolites in the fermentation process, including 7 esters, 6 alcohols, 4 acids, 3 phenols, 1 hydrocarbon, and 2 other compounds. Redundancy analysis was used to explore the correlation between dominant microbial genera and physicochemical properties. Starch was the main physicochemical property affecting microbial succession in the SF. Acidity, moisture, and reducing sugar were the main driving factors of microbial succession in the CF. The Pearson correlation coefficient revealed the correlation between dominant microbial genera and significantly different volatile flavor substances. A total of 18 dominant microbial genera were associated with significantly different volatile metabolites, Lactobacillus, Weissella, Wickerhamomyces, and Aspergillus were shown to play crucial roles in metabolite synthesis. On this basis, a metabolic map of the dominant microbial genera was established. This study provides a theoretical basis for the production and quality control of sauce-flavor Baijiu brewed in natural karst caves and lays a foundation for studying the link between flavor formation and microorganisms.
Comparison of Upper Airway Ultrasonography With End-Tidal Capnography for the Confirmation of Endotracheal Tube Placement in Patients Requiring General Anesthesia

Introduction End-tidal capnography (EtCO2) has been the gold standard method for confirmation of endotracheal intubation. Upper airway ultrasonography (USG) is a new promising method for confirming endotracheal tube (ETT) placement and has the potential to become the first-line non-invasive airway assessment tool in the future thanks to widespread POCUS knowledge, greater technology improvements, portability, and availability of ultrasound in the majority of essential areas. Hence our study aimed to compare upper airway USG and EtCO2 for the confirmation of ETT placement in patients undergoing general anesthesia. Aim To compare the upper airway USG with EtCO2 for confirmation of ETT placement in patients requiring general anesthesia for elective surgical procedures. The objectives of the study were to compare the time taken for confirmation, and the number of correct identification of tracheal and esophageal intubation by both upper airway USG and EtCO2. Materials and methods After obtaining institutional ethical committee (IEC) approval, a prospective randomized comparative study involving 150 patients under American Society of Anesthesiologists (ASA) grade I and II requiring endotracheal intubation for elective surgeries under general anesthesia was randomized into two groups, Group U-upper airway USG and Group E-EtCO2 with 75 patients in each group. ETT placement confirmation was done by upper airway USG in Group U and by EtCO2 in Group E and the time taken for confirmation of ETT placement and correct identification of esophageal and tracheal intubation by USG and EtCO2 was noted. Results The demographic details among both groups were statistically insignificant. Upper airway USG had a faster average confirmation time of 16.41 seconds when compared to EtCO2 which took an average confirmation time of 23.56 seconds. In our study, upper airway USG was able to identify esophageal intubation with 100% specificity. Conclusion Upper airway USG can be a reliable method and can be employed as a standard method for confirmation of ETT location in patients undergoing elective surgeries under general anesthesia when compared to EtCO2.
Epidemic Diffusion Network of Spain: A Mobility Model to Characterize the Transmission Routes of Disease

Human mobility drives the geographical diffusion of infectious diseases at different scales, but few studies focus on mobility itself. Using publicly available data from Spain, we define a Mobility Matrix that captures constant flows between provinces by using a distance-like measure of effective distance to build a network model with the 52 provinces and 135 relevant edges. Madrid, Valladolid and Araba/Álaba are the most relevant nodes in terms of degree and strength. The shortest routes (most likely path between two points) between all provinces are calculated. A total of 7 mobility communities were found with a modularity of 63%, and a relationship was established with a cumulative incidence of COVID-19 in 14 days (CI14) during the study period. In conclusion, mobility patterns in Spain are governed by a small number of high-flow connections that remain constant in time and seem unaffected by seasonality or restrictions. Most of the travels happen within communities that do not completely represent political borders, and a wave-like spreading pattern with occasional long-distance jumps (small-world properties) can be identified. This information can be incorporated into preparedness and response plans targeting locations that are at risk of contagion preventively, underscoring the importance of coordination between administrations when addressing health emergencies.
Investigation of the Southern Hemisphere Mid‐High Latitude Thermospheric ∑O/N2 Responses to the Space‐X Storm

The geomagnetic storm on February 3, 2022 caused the loss of 38 Starlink satellites of Space‐X. The Global‐scale Observations of the Limb and Disk (GOLD) observations and Multi‐Scale Atmosphere Geospace Environment (MAGE) model simulations are utilized to investigate the thermospheric composition responses to the Space‐X storm. The percentage difference of the GOLD observed thermospheric O and N2 column density ratio (∑O/N2) between the storm time (February 3, Day‐of‐Year [DOY] 34) and quiet time (DOY 32) shows a depletion region in the local noon sector mid‐high latitudes in the southern hemisphere, which corresponds to the east side of GOLD field‐of‐view (FOV). This is different from the classic theory of thermospheric composition disturbance during geomagnetic storms, under which the ∑O/N2 depletion is usually generated at local midnight and high latitudes, and thus, appear on the west side of GOLD FOV. MAGE simulations reproduce the observations qualitatively and indicate that the ∑O/N2 depletion is formed due to strong upwelling in the local morning caused by strong Joule heating. Interestingly, enhanced equatorward winds appear near local midnight, but also in the local morning sector, which transports ∑O/N2 depletion equatorward. The depletion corotates toward the local afternoon and is observed in the GOLD FOV. The equatorward winds in the local morning are due to the ion‐neutral coupling under the conditions of a dominant positive interplanetary magnetic field east‐west component (By) during the storm.
Comparison of the effects of spinal anesthesia, paracervical block and general anesthesia on pain, nausea and vomiting, and analgesic requirements in diagnostic hysteroscopy: A non-randomized clinical trial

Background The aim of this study was to compare the effect of spinal anesthesia (SPA), paracervical block (PB), and general anesthesia (GA), on pain, the frequency of nausea and vomiting and analgesic requirements in diagnostic hysteroscopy. Methods This single-center, non-randomized, parallel-group, clinical trial was conducted on 66 diagnostic hysteroscopy candidates who were selected by convenience sampling at Fatemieh Hospital, in Hamadan, Iran, in 2021. Results The mean pain score during recovery and the need for analgesic injections was found to be significantly higher in the GA group compared to that in the SPA group (pain: 3.77 ± 2.25 vs. 0.10 ± 0.30, P < 0.001), (analgesic: 50 vs. 0%, P < 0.001) and PB group (pain: 3.77 ± 2.25 vs. 0.90 ± 1.37, P < 0.001), (analgesic 50 vs. 10%, P < 0.001), respectively. However, no statistically significant difference was observed between the mean pain score between SPA and PB groups (0.10 ± 0.30 vs. 0.90 ± 1.3, P = 0.661). In addition, there were no significant differences between groups on nausea/vomiting after operation (P = 0.382). In adjusted regression analysis (adjusting for age, weight, gravid, abortion, and cause of hysteroscopy), the odds ratio (OR) of pain score during recovery was increased in PB (OR: 4.471, 95% CI: 1.527–6.156, P = 0.018) and GA (OR: 8.406, 95% CI: 2.421–9.195, P = 0.001) groups compared with the SPA group. However, in adjusting based on times of surgery duration, anesthesia duration, recovery and return of motor function, the ORs of pain score between groups was not statistically significant. Conclusion Despite reduced pain during recovery in patients receiving SPA, duration of anesthesia, recovery period, and return of motor function were significantly prolonged compared to those receiving PB or GA. It seems that PB with less recovery time and faster return of motor function than SPA and also mild pain during recovery compared to GA can be a good option for hysteroscopy. Clinical trial registration http://www.irct. ir, identifier IRCT20120915010841N26.
Impact-ionization-assisted intermediate band solar cell

The effect on the efficiency of the intermediate band solar cell of certain types of impact ionization mechanisms is studied. It turns out to have several interesting advantages. For example, this mechanism may lead to cells with an efficiency that, although similar to that of the multijunction cells, would be otherwise very insensitive to the spectral mismatch. The efficiency of structures of p, n, or intrinsic type is also discussed in addition to the metallic intermediate band analyzed in earlier works.