Miracle-dz/UniFAR-FTUs huggingface dataset:
Intermediate-conductance Ca 2-activated K channel is expressed in C 2 C 12 myoblasts and is downregulated during myogenesis

Fioretti, Bernard, Tiziana Pietrangelo, Luigi Catacuzzeno, and Fabio Franciolini. Intermediate-conductance Ca -activated K channel is expressed in C2C12 myoblasts and is downregulated during myogenesis. Am J Physiol Cell Physiol 289: C89–C96, 2005. First published March 2, 2005; doi:10.1152/ajpcell.00369. 2004. —We report here the expression in C2C12 myoblasts of the intermediateconductance Ca -activated K (IKCa) channel. The IKCa current, recorded under perforated-patch configuration, had a transient time course when activated by ionomycin (0.5 M; peak current density 26.2 3.7 pA/pF; n 10), but ionomycin (0.5 M) 5,6-dichloro1-ethyl-1,3-dihydro-2H-benzimidazol-2-one (100 M) evoked a stable outward current (28.4 8.2 pA/pF; n 11). The current was fully inhibited by charybdotoxin (200 nM), clotrimazole (2 M), and 5-nitro-2-(3-phenylpropylamino)benzoic acid (300 M), but not by tetraethylammonium (1 mM) or D-tubocurarine (300 M). Congruent with the IKCa channel, elevation of intracellular Ca in inside-out patches resulted in the activation of a voltage-insensitive K channel with weak inward rectification, a unitary conductance of 38 6 pS (at negative voltages), and an IC50 for Ca of 530 nM. The IKCa channel was activated metabotropically by external application of ATP (100 M), an intracellular Ca mobilizer. Under current-clamp conditions, ATP application resulted in a membrane hyperpolarization of 35 mV. The IKCa current downregulated during myogenesis, ceasing to be detectable 4 days after the myoblasts were placed in differentiating medium. Downregulation was prevented by the myogenic suppressor agent basic FGF (bFGF). We also found that block of the IKCa channel by charybdotoxin did not inhibit bFGF-sustained myoblast proliferation. These observations show that in C2C12 myoblasts the IKCa channel expression correlates inversely with differentiation, yet it does not appear to have a role in myoblast proliferation.
Accelerometry-assessed daily physical activity and compliance with recommendations in Spanish children: importance of physical education classes and vigorous intensity

Background Physical activity (PA) is associated with numerous health benefits. Vigorous PA (VPA) may have a greater impact on public health than lower-intensity PA. The incorporation of a specific recommendation on VPA could complement and improve existing recommendations for average daily moderate-vigorous PA (MVPA). Physical education classes could have a positive impact on children’s adherence to average daily physical activity recommendations. The aim was to investigate the association between MVPA and VPA in children, as well as adherence to recommendations, and obesity and the presence of physical education classes. Methods A cross-sectional study of physical activity was conducted in a sample of 8 and 9-year-old children in Andalusia (Spain). GENEActiv accelerometers were used, placed on the non-dominant wrist for at least eight consecutive days (24-h protocol). School days with and without physical education class, and weekend days were defined. ROC curves were used to calculate the threshold associated with obesity for average daily MVPA and VPA for recommendations. Results A total of 360 schoolchildren were included in the analyses (184 girls). An average of 7.7 (SD 1.4) valid days per participant were evaluated, with 19.9 (SD 10.5) and 11.4 (SD 5.1) minutes of VPA performed by boys and girls respectively. 25.8% of the participants were classified with central obesity. The optimal threshold determined with ROC analysis was 12.5 and 9.5 minutes of average daily VPA for boys and girls, respectively (RecVPA), and 75 minutes of average daily MVPA for both sexes (RecMVPA). The RecVPA showed stronger association with obesity. On school days with physical education class, compared to days without this class, children showed increased VPA and MVPA engagement and better compliance with recommendations, with smaller differences in adherence according to sex or obesity. Conclusions On days with physical education class, more physical activity was accumulated at all intensities and greater adherence to the recommendations than on days without this class. VPA had a stronger correlation with the absence of obesity than lower-intensity activity. It was also observed that boys were physically more active and had higher adherence to the recommendations than girls.
Integration of natural selection across the life cycle stabilizes a marine mussel hybrid zone

Abstract Hybridization among related species is now recognized as common but it remains unclear how hybrid zones persist for prolonged periods. Here, we test the hypothesis that selection in different components of the life cycle may stabilize a hybrid zone. A hybrid zone occurs in southwest England between the marine mussels Mytilus edulis and M. galloprovincialis. Previous studies have found strong directional selection against alleles from M. edulis occurs among hybrids in the adult stage. Traditional hybrid zone models argue that alleles that are selected within the hybrid zone are replaced by migration from neighboring parental population into the hybrid zone. In this system, however, migration occurs out of this hybrid zone into neighboring parental populations. This hybrid zone should therefore be unstable and dissipate, yet this zone has persisted for more than 30 years. We tested and rejected the hypothesis that differences in fecundity may select for M. edulis alleles within this hybrid zone and thus counter the selection observed against these alleles among adults. We also tested the hypothesis that selection during the larval stage may counter selection against M. edulis alleles in the adult stage. We found that selection favors M. edulis alleles during the veliger stage of larval development. The direction and strength of selection during the larval stage are sufficient to counter strong selection during the adult portion of the life cycle. This hybrid zone is stabilized by opposing forms of directional selection operating in different portions of the life cycle.
Work engagement influencing factors of Japanese midwives working in prenatal medical centers

INTRODUCTION There have been significant changes in the work environment of midwives, such as the establishment of prenatal medical centers and shared wards for obstetrics and other departments. These changes in the work environment pose a psychological burden on midwives. Under these circumstances, the concept of work engagement is essential for overcoming the ensuing difficulties. However, no studies have yet investigated midwives working in prenatal medical centers in Japan. This study examined the factors affecting work engagement among midwives working in prenatal medical centers in Japan. METHODS A cross-sectional survey of 498 midwives working at prenatal medical centers nationwide was conducted. Data were analyzed using the Mann-Whitney U test or Kruskal-Wallis test, correlation analysis using Spearman’s rank correlation coefficient, and multiple regression analysis as linear regression. RESULTS The median of work engagement score was 3.00 (IQR: 2.40–3.60). The multiple linear regression analysis showed that professional identity (β=0.494, p<0.001), resilience (β=0.243, p<0.001), presence of in-hospital midwifery in the facility (β=0.138, p<0.011), and age (β=0.085, p=0.021) were significant. The adjusted R2 value was 0.490 (p<0.001). CONCLUSIONS These results offer management insights into improving work engagement among midwives working in prenatal medical centers in Japan. The proposed measures include hospital/ward administrators establishing the professional identity of midwives and providing them with opportunities to demonstrate their expertise, for instance, within in-hospital midwifery systems at perinatal medical centers.
Water table depth and plant species determine the direction and magnitude of methane fluxes in floodplain meadow soils

Abstract Methane (CH4) is a powerful greenhouse gas with ongoing efforts aiming to quantify and map emissions from natural and managed ecosystems. Wetlands play a significant role in the global CH4 budget, but uncertainties in their total emissions remain large, due to a combined lack of CH4 data and fuzzy boundaries between mapped ecosystem categories. European floodplain meadows are anthropogenic ecosystems that originated due to traditional management for hay cropping. These ecosystems are seasonally inundated by river water, and straddle the boundary between grassland and wetland ecosystems; however, an understanding of their CH4 function is lacking. Here, we established a replicated outdoor floodplain‐meadow mesocosm experiment to test how water table depth (45, 30, 15 cm below the soil surface) and plant composition affect CH4 fluxes over an annual cycle. Water table was a major controller on CH4, with significantly higher fluxes (overall mean 9.3 mg m−2 d−1) from the high (15 cm) water table treatment. Fluxes from high water table mesocosms with bare soil were low (mean 0.4 mg m−2 d−1), demonstrating that vegetation drove high emissions. Larger emissions came from high water table mesocosms with aerenchymatous plant species (e.g. Alopecurus pratensis, mean 12.8 mg m−2 d−1), suggesting a role for plant‐mediated transport. However, at low (45 cm) water tables A. pratensis mesocosms were net CH4 sinks, suggesting that there is plasticity in CH4 exchange if aerenchyma are present. Plant cutting to simulate a hay harvest had no effect on CH4, further supporting a role for plant‐mediated transport. Upscaling our CH4 fluxes to a UK floodplain meadow using hydrological modelling showed that the meadow was a net CH4 source because oxic periods of uptake were outweighed by flooding‐induced anoxic emissions. Our results show that floodplain meadows can be either small sources or sinks of CH4 over an annual cycle. Their CH4 exchange appears to respond to soil temperature, moisture status and community composition, all of which are likely to be modified by climate change, leading to uncertainty around the future net contribution of floodplain meadows to the CH4 cycle.
The association between lymphocyte to high‐density lipoprotein ratio and depression: Data from NHANES 2015–2018

Abstract Introduction The relationship of lymphocyte to high‐density lipoprotein ratio (LHR) with depression remains uncertain. We aimed to evaluate the association between LHR and depression in US adults. Methods In this cross‐sectional study, a total of 4216 participants were enrolled from the National Health and Nutrition Examination Survey (2015–2018). Depressive symptoms were measured with the Patient Health Questionnaire‐9 (PHQ‐9). Participants were classified as having depression if PHQ‐9 scores were ≥10. Multiple logistic regression models were used to explore the relationship between the LHR and depression. Results Overall, the LHR was significantly associated with depression (per standard deviation increment; adjusted odds ratio (OR), 1.31; 95% confidence interval (CI) [1.14, 1.50]) after adjusted potential variables. Interactions between LHR with metabolic syndrome (MetS) and body mass index (BMI) on the risk of depression were found in stratified analysis (p for interaction < .05). Conclusions A higher level of LHR was significantly associated with higher odds of having depression in US adults, and it was strengthened in participants with MetS or BMI ranging from 25 to 30 kg/m2.
Characteristics and variations of sinters in the Coromandel Volcanic Zone: application to epithermal exploration

ABSTRACT The Hauraki Goldfield of the Coromandel Volcanic Zone, North Island, New Zealand, hosts up to 19 known siliceous hot spring deposits, or sinters, some directly associated with Au–Ag ore bodies, in a Miocene–Pliocene, sub-aerial, calc-alkaline volcanic arc overlying Jurassic meta-sedimentary basement. Sinters are surface expressions of predominately adularia-sericite epithermal systems, potentially linked to Au–Ag mineralised conduits at depth. They provide a paleosurface marker to determine the level of erosion, and help determine zones of thermal fluid upflow and/or lateral outflow. Mapped sinters of the Coromandel Volcanic Zone are mainly affiliated with rhyolite domes, occur along structural corridors of the volcanic arc, and contain characteristic textures, mineralogy and pathfinder elements typical of near-neutral pH alkali chloride fluid discharge derived from convectively circulating magmatic fluids diluted by meteoric waters. Textures and trace element compositions of the Coromandel sinters are similar to those of the Taupo Volcanic Zone, New Zealand, and the Jurassic Au–Ag mining districts of the Deseado Massif, Argentine Patagonia. Thus, detailed mapping, textural analysis and trace-element studies demonstrate the prospecting potential of siliceous hot spring deposits for locating ore deposits, and in particular to help define proximal to distal positions relative to vent zones at the paleo-surface.
Global and Interregion Characterization of Subduction Interface Earthquakes Derived From Source Time Functions Properties

Source time functions (STFs) describe how the seismic moment rate is released with time, and carry information on integral rupture properties, such as static stress drop and radiated energy. In this study, we systematically analyze a set of 1,433 STFs extracted from the SCARDEC method (Vallée and Douet, 2016, https://doi.org/10.1016/j.pepi.2016.05.012), containing the Mw≥5.6, shallow (z≤70 km) earthquakes with dip‐slip mechanism that occurred between 1992 and 2014. At the global scale, STFs properties indicate scale invariance of stress drop and scaled radiated energy with magnitude. In a second step, these source parameters are investigated in light of the tectonic context of the earthquakes: in agreement with other approaches, we observe that subduction interface earthquakes have lower stress drop and scaled radiated energy relative to all other earthquakes (e.g., crustal earthquakes). Finally, a focus on subduction interface earthquakes (approximately 800 earthquakes) is done by considering 18 regional segments of subduction zones. We find that these segments do not have the same signature in terms of macroscopic rupture properties, which means that large‐scale plate convergence and mechanical properties influence rupture behavior. In a given segment, local heterogeneities of stress drop or radiated energy can be associated with local features of the subduction zone: in particular, we find that low coupled zones generate earthquakes with low stress drop and scaled radiated energy. This last feature, also observed at a larger scale, suggests a positive correlation between coupling and stress drop.
Effectiveness of SCAR‐Q for assessment of incisional SCAR after implant‐based reconstruction in breast cancer patients: Can it be a tool for incision selection?

Abstract Incisional scarring is a factor of cosmetic appearance evaluated after breast reconstruction, along with the shape, position, and size of the breast. This study aimed to examine the effect of the incision scar location on patient satisfaction after breast reconstruction. Using the Japanese version of the SCAR‐Q, we assessed the scar appearance, symptoms and psychosocial effects. Plastic surgeons performed assessments using the Manchester Scar Scale. The patients were divided into two groups: those with scars on the margins of the breast (MB group) and those with scars in the breast area (IB group). The results revealed that patients in the MB group reported significantly higher satisfaction with the scar appearance and psychological impact than those in the IB group. However, assessments using the Manchester Scar Scale did not reveal any significant differences between the two groups. In conclusion, this study underscores the importance of patient‐reported outcomes in the evaluation of scar satisfaction after breast reconstruction. Patients tend to prefer and have higher satisfaction with scars along the breast margin, which offers valuable insights into surgical decisions. Further studies with larger and more diverse sample sizes are required for validation.
Impact of Projected Climate Change on Summer Mungbean in Gujarat

The most important variable in climate change is temperature. One of the major effects of increases in temperature is to speed up the period of growth of the crop, especially in the grain-filling stage, resulting in lower yields. This effect is especially pronounced in semitropical and tropical conditions, since in these areas many crops are already at the outer limits of the temperatures that they can tolerate. Other significant consequences of increased temperatures include increase in the transpiration rate and accelerated loss of soil moisture, both of which increase the water demand of a crop. The daily maximum temperatures in Gujarat during summer season are frequently exceeding 39 o to 40 o C, which International Journal of Current Microbiology and Applied Sciences ISSN: 2319-7706 Volume 7 Number 08 (2018) Journal homepage: http://www.ijcmas. com
Systematic review and quality assessment of clinical and economic evidence for superabsorbent wound dressings in a population with chronic ulcers

Abstract Effective exudate management is key for optimal ulcer healing. Superabsorbent dressings are designed to have high fluid handling capacity, reduced risk of exudate leakage, fluid retention under compression, and to sequester harmful exudate components. This study aimed to systematically identify existing evidence for the clinical efficacy and cost‐effectiveness of superabsorbent dressings for the treatment of moderate‐to‐highly exudating chronic ulcers of various etiologies. The aim is focused on examining the ‘class’ effect of all superabsorbers, not any particular dressing. Clinical and cost effectiveness systematic reviews were conducted, searching Embase, MEDLINE, the Cochrane Library, and the Cumulative Index to Nursing and Allied Health Literature. The Cost Effectiveness Analysis Registry and Econ papers were also searched for the economic review. Outcomes of interest included ulcer closure, dressing properties, hospital‐ and infection‐related outcomes, safety, and economic outcomes. Fourteen studies were included in the clinical systematic review. Eleven were case series, with one randomised controlled trial, one retrospective matched observational study, and one retrospective cohort study. The studies investigated eight superabsorbent dressings and were heterogeneous in their patient population and outcomes. Superabsorbent dressings may result in favourable outcomes, including reductions in frequency of dressing change and pain scores. As most studies were case series, drawing firm conclusions was difficult due to absence of a comparator arm. The economic systematic review identified seven studies, five of which were cost‐utility analyses. These suggested superabsorbent dressings are a more cost‐effective option for the treatment of chronic ulcers compared with standard dressings. However, the small number and low quality of studies identified in both reviews highlights the need for future research.
Effects of Planting Time, Irrigation System, Rooting Medium, and IBA Concentration on Cutting Propagation of the Persimmon Dwarfing Rootstock ‘MKR1’

A practical dwarfing rootstock for the persimmon (Diospyros kaki Thunb.), ‘MKR1’, is normally propagated by cuttings collected from root suckers. However, optimal conditions for propagating leaf-bud cuttings from this variety have not been researched. Thus, several methods influencing survival, rooting and root system structure were investigated in the present study. Cuttings planted in late June survived and rooted better than those planted in late July and August, and the rooted cuttings planted in late June also survived winter better. The two different irrigation methods, either a mist system, or a tray with a polyethylene tent (traypolyethylene-tent, or TPT) did not significantly affect survival and rooting. However, the primary root length was longer in the TPT and the root dry weight was heavier under the mist system. Although the rooting medium did not significantly affect the survival of cuttings, the rooting percentage of cuttings planted in perlite was the lowest. The cuttings planted in peat in late June and placed under the mist system had adventitious root initials 17 days after planting and adventitious roots were observed on the cuttings by 22 days after planting. A quadratic regression curve predicted that the highest rooting percentage would result from treatment of ‘MKR1’ cuttings with approximately 2000 mg·L−1 indole-3-butyric acid (IBA), while a different curve predicted that the lowest root number would result from treatment with approximately 1000 mg·L−1 IBA. Interestingly, more than 50% of the cuttings treated with a quick dip in 0 mg·L−1 IBA successfully rooted. Although the treatment with a higher IBA concentration resulted in greater root system development on the rooted cuttings, treatment with very high IBA concentrations such as 4000 or 5000 mg·L−1 caused fading of leaves and dieback of cuttings.
Evaluation of Ionizing Radiation Protection among Radiation Workers in X-ray departments in Erbil City

Background: Ionizing radiations are hazardous agents in the workplace, since all forms of ionizing radiation produce some type of injury that is incurable. Therefore, protection against ionizing radiation exposure can play an important role in the health of workers.Objectives: is to evaluate the application of radiation protection among radiation workers at X-ray department in Erbil hospitals.Patients and methods: Six hospitals (General and Private) were visited. Samples of 110 were randomly selected among 135 radiation workers, 47 (42.3%) female and 63 (57.3%) male Data was collected through structured questionnaires. The surveyed data was coded and analyzed by using MS Excel software, and SPSS 18 for analysis. Analysis was performed by means of frequency distributions and cross tabulations.Results: The results showed that there are majority of the workers 51 (46.4%) aged between 21 - 30 years, and Diploma holders 68 (61.8%). Only 49 (44.5%) undergone primary examination while 47 (42.7%) never done periodical examination. According to international commotion of radiation protection regulation of radiation protection, it is mandatory for radiation workers to wear personal detective devices during work. But a large numbers 89 (80.9%) have not supplied with such devices. The study also revealed that the majority of workers were engaged in work beyond 40 hours per week. Calibration of the X-rays machine and radiation survey of the work place have not been regularly done. Only 30 of the sample have no awareness and knowledge about the ionizing radiation, while 95 (86.4%) have no healthy advice.Conclusion: It can be suggested that the level of workers education must be increased and short courses be implemented such as dosimetery and radiation protection performance.
Onscreen presence of instructors in video lectures affects learners’ neural synchrony and visual attention during multimedia learning

Significance COVID-19 forced students to rely on online learning. Although the pandemic has subsided, online learning through multimedia instructional videos continues to shape education. This study evaluates the key principles associated with students’ processing of socio-emotional cues in multimedia learning. Our findings support the learning benefits of the social presence of both human and virtual instructors in online videos, with benefits varying across individuals. The data suggest a trade-off mechanism where socio-emotional processing must outweigh concurrent visual distractions to improve learning outcomes. Our findings hold significant implications for today’s education in a digital era, where online video learning is prevalent.