Miracle-dz/UniFAR-FTUs huggingface dataset:
"Enclaves" private a carattere residenziale: il caso del "cohousing"

Although recently it is receiving increasing public attention, cohousing is still a fuzzy contours phenomenon, often analyzed in an hagiographic way. Therefore the paper proposes a critical reflection which, through taxonomic analysis and comparison with gated communities, brings cohousing within the «family» to which it belongs: residential private community, with which cohousing shares all the well-know problems. The paper is divided into two sections. In the first one, (§ 1) the author provides a descriptive overview of cohousing; in the second one (§ 2 and 3), after a taxonomical classification proposal, the author highlights main topical and critical cohousing characters.
Extreme cold weather causes the collapse of a population of Lambdina fiscellaria (Lepidoptera: Geometridae) in the Laurentian Mountains of Québec, Canada

Abstract In 2012, an unexpected outbreak of Lambdina fiscellaria (Guenée) (Lepidoptera: Geometridae) occurred in the Laurentian Mountains, Québec, Canada, known for its harsh climate. We wondered whether the eggs were sufficiently cold hardy to survive there and, if so, how long this outbreak would last. Therefore, we assessed the capacity of the eggs to supercool, to tolerate short exposures to low sub-zero temperatures, or to successfully overwinter in the field. The same assays were performed with eggs from the island of Newfoundland, Newfoundland and Labrador, Canada. The mean supercooling point of eggs from the two populations increased from −40.2 °C in mid-February to −33.7 °C in mid-May. These eggs may also die at sub-zero temperatures above their supercooling point, depending on exposure durations. In the fall of 2012 when eggs were put out in the field, < 10% survived in the Laurentian Mountains, whereas > 70% survived further south. In the spring of 2013, no parasitism was detected in the population. However, the two cold waves that swept across the Laurentian Mountains the preceding winter were likely responsible for the collapse of the population. This study demonstrates that L. fiscellaria eggs may succumb to sub-zero temperatures above their supercooling point under field conditions. Résumé En 2012, une épidémie inattendue de Lambdina fiscellaria (Guenée) (Lepidoptera: Geometridae) s’est déclarée dans les Laurentides, une région froide du Québec, Canada. Nous avons donc examiné si les œufs étaient suffisamment résistants au froid pour y survivre et si oui, combien de temps durerait l’épidémie. Pour ce faire, la capacité des œufs à entrer en surfusion, à tolérer de courtes expositions sous les 0 °C ou à hiverner avec succès a été mesurée. Des œufs de l’Ⓘle de Terre-Neuve, Terre-Neuve et Labrador, Canada ont aussi été testés. Les points de surfusion des œufs des deux populations sont passés de −40.2 °C (mi-février) à −33.7 °C (mi-mai). Selon la durée d’exposition, les œufs pouvaient aussi mourir à des températures supérieures à leurs points de surfusion. À l’automne 2012, lorsque les œufs ont été placés sur le terrain, < 10% ont survécu dans les Laurentides comparativement à > 70% plus au sud. Au printemps 2013, aucun parasitisme n’a été détecté dans la population. Cependant, les froids qui ont balayé les Laurentides l’hiver précédent ont vraisemblablement causé le déclin de cette population. Cette étude démontre que les œufs de L. fiscellaria peuvent succomber à des températures supérieures à leurs points de surfusion sur le terrain.
Low-temperature tolerance of maize and sorghum seedlings grown under the same environmental conditions

ABSTRACT Even though maize (Zea mays L.) is considered to be more cold tolerant than sorghum [Sorghum bicolor (L.) Moench], no studies have directly compared the ability of the two crops to tolerate low temperature when grown together under the same environmental conditions. Therefore, the objective of this experiment was to compare the low-temperature tolerance of the two crops at the seedling stage. A second objective was to analyze seeds for size (width and weight) and biochemical characteristics (content of protein, starch, and amylose). Five commercial hybrids of maize and 18 genotypes of sorghum were maintained in growth chambers for 31 days at two temperatures: a control air temperature (25/20°C, day/night) and low temperatures of the air (11/8°C for 14 days; 12.5/9.5°C for 14 days; and 14/11°C for 3 days). Both maize and sorghum seedlings emerged when the low temperatures reached 12.5/9.5°C; 100 and 18% of the emerged maize and sorghum seedlings survived, respectively. At harvest of maize under the control and low temperatures, mean shoot dry weights per plant were 4.16 g and 0.03 g, respectively. At harvest of sorghum under the control temperature, mean shoot dry weight per plant was 1.33 g. The sorghum plants grown under the low temperatures were too small for measurement of shoot dry weight. Mean widths of the maize and sorghum seeds were 7.9 mm and 2.6 mm, respectively. Maize was found to be more low-temperature tolerant than sorghum, perhaps attributable, in part, to its larger seed size.
Formulation and Preparation of Losartan-Potassium-Loaded Controlled-Release Matrices Using Ethocel Grade 10 to Establish a Correlation between In Vitro and In Vivo Results

In the current study, matrices of losartan potassium were formulated with two different polymers (Ethocel 10 premium and Ethocel 10FP premium), along with a filler and a lubricant, at different drug-to-polymer w/w ratios (10:3, 10:4, and 10:5). The matrices were tested by the direct compression method, and their hardness, diameter, thickness, friability, weight variation, content uniformity, and in vitro dissolution tests were assessed to determine 24-h drug release rates. The matrices with Ethocel 10 FP at a 10:4 ratio exhibited pseudo-zero-order kinetics (n-value of 0.986), while the dissolution data of the test matrices and reference tablets did not match. The new test-optimized matrices were also tested in rabbits, and their pharmacokinetic parameters were investigated: half-life (11.78 ± 0.018 h), Tmax (2.105 ± 1.131 h), Cmax (205.98 ± 0.321 μg/mL), AUCo (5931.10 ± 1.232 μg·h/mL), AUCo-inf (7348.46 ± 0.234 μg·h/mL), MRTo-48h (17.34 ± 0.184 h), and Cl (0.002 ± 0.134 mL/min). A correlation value of 0.985 between the in vitro and in vivo results observed for the test-optimized matrices was observed, indicating a level-A correlation between the percentage of the drug released in vitro and the percentage of the drug absorbed in vivo. The matrices might improve patient compliance with once-a-day dosing and therapeutic outcomes.
Using landowner knowledge and field captures to determine habitat use by the northern prairie skink (Plestiodon septentrionalis) on exurban residential land in southwestern Manitoba

Exurban development, consisting of low density residential housing in a rural setting, is steadily increasing in North America. This increase may have negative impacts on the habitat for some species, through the introduction of non-native plants and new predators such as house cats. The northern prairie skink (Plestiodon septentrionalis) is listed as Endangered in Canada occurring only in southwestern Manitoba. The objectives of this study included: a) defining prairie skink microhabitat use on private land according to vegetation, temperature and cover availability, b) determining landowner awareness of prairie skinks on their property, and c) determining how landowner stewardship could be used in skink conservation. Mixed methods strategy of inquiry was utilized and data collection procedures included both quantitative habitat surveys and qualitative landowner interviews. I found that prairie skinks were most often found in prairie habitat, and were found most often in areas with a) high percent artificial cover, b) high leaf litter, and c) more pieces of cover per acre. Landowners most often saw skinks near buildings, in flower beds and in debris piles. Landowner attitudes towards skinks were positive, though willingness may not translate into action.
Utilising time of use surveys to predict domestic hot water consumption and heat demand profiles of residential building stocks

Aims: The prediction of water consumption patterns is a challenge, especially when water metering is not available at scale. The use of time-of-use survey (TUS) data offers an alternative to metering in order to track the general patterns of water consumption across large and representative groups of end-users. The paper focuses on the prediction of analytical domestic hot water (DHW) demand profiles for detailed building archetype models, using an occupant focused approach based on TUS data. The paper illustrates and discusses the resulting capability of dwelling archetypes to capture variations in heat demand and energy usage for water heating on a national scale and at high time resolution. Methodology: Five dwelling types are considered over different construction periods, representative of the majority of the Irish residential stock, which is used here as a case study. They are modelled at room level using EnergyPlus and converted into archetype models. A bottom-up approach is utilised to develop the required operational data at high space and time resolution. That methodology applies Markov Chain Monte Carlo techniques to TUS activity data to develop activity-specific profiles for occupancy and domestic equipment electricity use. It is extended to DHW demand profiles by combining the probability distributions for particular TUS activities with average daily DHW consumptions, depending on the household size, day type and season. Results: The archetype models capture variations in DHW consumption, heat demand and energy usage for DHW heating, on a national scale and a fifteen-minute basis. Moreover, they are found to be 90% accurate with the Irish standard dwelling energy assessment procedure in estimating the annual energy requirements for DHW heating. Conclusion: This study demonstrates the potential for utilising time of use surveys to predict domestic water demand profiles on a national scale and at high time resolution.
Ocular morbidity patterns among metal workers from an unorganized sector: A cross-sectional study

Introduction and Aim: The metal working process has many hazards that the metal workers are exposed to resulting in several health disorders and diseases. However, there is a lack of documented information regarding the prevalence of ophthalmic safety practices and the factors influencing them among metal workers in the Moradabad region or the study area. The aim of the present study is to assess ocular morbidity patterns among the metal workers from an unorganized sector. Methods: We conducted this study to find out the morbidity patterns among the metal workers working in Northwestern Uttar Pradesh, district Moradabad. A cross-sectional study was conducted among 100 metal workers using a pre-validated structured questionnaire. Results: All the metal workers working, without any formal eye health and safety training. Eye Injury was the most common problem at work. The age of the metal workers, duration of employment & welding hours per day were associated with ocular morbidities among the metal workers. In this study, among 100 metal workers, 18% of workers were suffering from an occupational eye injury. 98% metal workers population don’t have any personal protective eye device.86% of them feel this protective eye device is not so necessary. Conclusion: There is a need for occupational health safety awareness services for metal workers in Moradabad as well as in Uttar Pradesh. While further research may be required to make policy recommendations, the current study provides a baseline morbidity burden among these mental workers to look for interventions to promote health and safety at work for this neglected unorganized group.
Clinical Characteristics and Management of Triple-Negative Breast Cancer (TNBC) in Jordan: A Retrospective Analysis

Introduction Triple-negative breast cancer (TNBC) is known for its aggressive nature and poor prognosis. Despite its responsiveness to chemotherapy, TNBC presents challenges in terms of survival, recurrence, and mortality rates, particularly in diverse populations. Limited research in the Middle East hampers comprehensive understanding and tailored management. Methods A retrospective study at the King Hussein Medical Center in Jordan between the period 2009 to 2023 explored TNBC patients (n=110) who underwent adjuvant chemotherapy after local excision or modified radical mastectomy (MRM). Data encompassed demographics, clinical variables, and operative details. Statistical analysis employed Wilcoxon and chi-squared tests, examining mortality risks and associations between variables. Results Among 110 TNBC patients (mean age 52), 84% underwent MRM, 16% wide local excision and axillary clearance (WLE&AC). Lymphovascular invasion (LVI) was observed in 41%, linked to higher lymph node positivity. Neoadjuvant therapy preceded MRM in 25% of cases. While 75% had grade III tumors, the prevalence of invasive ductal carcinoma was 85%. Conclusions This study contributes crucial insights into TNBC characteristics and management in Jordan. Despite limitations such as retrospective design and sample size, the findings underscore the need for tailored interventions in TNBC patients, emphasizing the importance of neoadjuvant therapy and vigilant consideration of LVI status in treatment planning. Future longitudinal research should delve into disease progression and treatment outcomes in diverse populations, facilitating optimized TNBC management strategies.
A study on the effect of music listening on people with high neurotic tendency 
as evidenced by negative affective scores and physiological responses

Music listening has been found to be effective in reducing stress levels with different participant samples. Relatively little evidence has been obtained from people with high neurotic tendency (HNT), whose dispositional psychological characteristics might dampen the effect of music listening. This study therefore tried to examine the immediate effect of music listening in reducing stressful feelings of participants with either high or low neurotic tendency.Seventy-nine undergraduate participants who were identified as having either HNT or low neurotic tendency (LNT) accomplished a stressful task before listening to a comforting music piece. Negative affect (NA) scores and heart rate were measured at different phases.Results in a within-subjects analysis showed that the stressor and music listening could significantly alter the stressful feeling of both participant groups. Although the percentage changes in heart rate were similar between the groups, the changes of NA score which were measured after either the stressful task or the music listening session were consistently lower in the HNT group than the LNT group.The divergence revealed a loose connection between the subjective feelings and the bodily changes in the HNT group, which could be important for clinicians and practitioners to take into consideration in psychology when evaluating the stressful feelings for their clients with HNT.
TRIM56: a promising prognostic immune biomarker for glioma revealed by pan-cancer and single-cell analysis

Tripartite-motif 56 (TRIM56) is a member of the TRIM family, and was shown to be an interferon-inducible E3 ubiquitin ligase that can be overexpressed upon stimulation with double-stranded DNA to regulate stimulator of interferon genes (STING) to produce type I interferon and thus mediate innate immune responses. Its role in tumors remains unclear. In this study, we investigated the relationship between the expression of the TRIM56 gene and its prognostic value in pan-cancer, identifying TRIM56 expression as an adverse prognostic factor in glioma patients. Therefore, glioma was selected as the primary focus of our investigation. We explored the differential expression of TRIM56 in various glioma subtypes and verified its role as an independent prognostic factor in gliomas. Our research revealed that TRIM56 is associated with malignant biological behaviors in gliomas, such as proliferation, migration, and invasion. Additionally, it can mediate M2 polarization of macrophages in gliomas. The results were validated in vitro and in vivo. Furthermore, we utilized single-cell analysis to investigate the impact of TRIM56 expression on cell communication between glioma cells and non-tumor cells. We constructed a multi-gene signature based on cell markers of tumor cells with high TRIM56 expression to enhance the prediction of cancer patient prognosis. In conclusion, our study demonstrates that TRIM56 serves as a reliable immune-related prognostic biomarker in glioma.
Greater reliance on model-free learning in adolescent anorexia nervosa: An examination of dual-system reinforcement learning

Alterations in learning and decision-making systems are thought to contribute to core features of anorexia nervosa (AN), a psychiatric disorder characterized by persistent dietary restriction and weight loss. Instrumental learning theory identifies a dual-system of habit and goal-directed decision-making, linked to model-free and model-based reinforcement learning algorithms. Difficulty arbitrating between these systems, resulting in an over-reliance on one strategy over the other, has been implicated in compulsivity and extreme goal pursuit, both of which are observed in AN. Characterizing alterations in model-free and model-based systems, and their neural correlates, in AN may clarify mechanisms contributing to symptom heterogeneity (e.g., binge/purge symptoms). This study tested whether adolescents with restricting AN (AN-R; n = 36) and binge/purge AN (AN-BP; n = 20) differentially utilized model-based and model-free learning systems compared to a healthy control group (HC; n = 28) during a Markov two-step decision-making task under conditions of reward and punishment. Associations between model-free and model-based learning and resting-state functional connectivity between neural regions of interest, including orbitofrontal cortex (OFC), nucleus accumbens (NAcc), putamen, and sensory motor cortex (SMC) were examined. AN-R showed higher utilization of model-free learning compared to HC for reward, but attenuated model-free and model-based learning for punishment. In AN-R only, higher model-based learning was associated with stronger OFC-to-left NAcc functional connectivity, regions linked to goal-directed behavior. Greater utilization of model-free learning for reward in AN-R may differentiate this group, particularly during adolescence, and facilitate dietary restriction by prioritizing habitual control in rewarding contexts.
Peripheral inflammatory markers relate to central inflammation and survival in syndromes associated with frontotemporal lobar degeneration

Neuroinflammation is an important pathogenic mechanism in many neurodegenerative diseases, including those caused by frontotemporal lobar degeneration (FTLD). There is a pressing need for scalable and mechanistically relevant blood markers of inflammation to facilitate drug development and experimental medicine. We assessed inflammatory profiles of serum cytokines from 214 patients with FTLD-associated syndromes (behavioural and language variants of frontotemporal dementia, progressive supranuclear palsy, corticobasal syndrome). We tested the association with brain microglial activation (by positron emission tomography) and survival. A pro-inflammatory profile across the FTLD spectrum (including TNF-, TNF-R1, M-CSF, IL-17A, IL-12, IP-10 and IL-6) differentiated patients (all syndromes) from controls. A higher pro-inflammatory profile scores was associated with higher microglial activation in frontal and brainstem regions, and with lower survival. Blood-based markers of inflammation could increase the scalability and access to neuroinflammatory assessment of people with dementia, to facilitate clinical trials and experimental medicine studies.
Intrinsic brain activity differences in perampanel-responsive and non-responsive drug-resistant epilepsy patients: an EEG microstate analysis

Background: Drug-resistant epilepsy (DRE) patients exhibit aberrant large-scale brain networks. Perampanel may be a therapeutic option for controlling seizures in these patients. Objective: We aim to explore the differences of resting-state electroencephalogram (EEG) microstate in perampanel-responsive and non-responsive DRE patients. Design: Retrospective study. Methods: Clinical data were collected from DRE patients who received perampanel treatment at the Fujian Medical University Union Hospital from June 2020 to September 2021, with a minimum follow-up of 6 months. Patients were classified into three groups based on the extent of reduction in seizure frequency: non-responsive (seizure reduction <50%), responsive (seizure reduction >50% but not seizure-free), and seizure-free. Resting-state EEG data sets of all participants were subjected to EEG microstate analysis. The study comprehensively compared the mean duration, frequency per second, and temporal coverage of each microstate among the three groups. Results: A total of 76 perampanel-treated DRE patients were categorized into three groups based on their response to treatment: non-responsive (n = 20), responsive (n = 36), and seizure-free (n = 20), according to the degree of seizure frequency reduction. The results of EEG microstate analysis revealed no statistically significant distinctions in frequency, duration, and coverage of microstate D in these DRE patients. However, the seizure-free group showed significantly increased duration and coverage of microstate A, frequency and coverage of microstate B, and significantly decreased duration, frequency, and coverage of microstate C when compared with the other groups. Conclusion: Microstate A, B, and D is associated with the sensorimotor network, visual network, salience network, and attention network, respectively. This study demonstrates statistically significant differences in the sensorimotor, visual, and salience networks, but not in the attention network, between perampanel-responsive and non-responsive DRE patients.
LRMP inhibits cAMP potentiation of HCN4 channels by disrupting intramolecular signal transduction

Lymphoid restricted membrane protein (LRMP) is a specific regulator of the hyperpolarization-activated cyclic nucleotide-sensitive isoform 4 (HCN4) channel. LRMP prevents cAMP-dependent potentiation of HCN4 but the interaction domains, mechanisms of action, and basis for isoform-specificity remain unknown. Here we identify the domains of LRMP essential for regulation. We show that LRMP acts by disrupting the intramolecular signal transduction between cyclic nucleotide binding and gating. And we demonstrate that multiple unique regions in HCN4 are required for LRMP isoform-specificity. Using patch clamp electrophysiology and Förster resonance energy transfer (FRET), we showed that the initial 227 residues of LRMP and the N-terminus of HCN4 are necessary for LRMP to interact with HCN4. We found that the HCN4 N-terminus and HCN4-specific residues in the C-linker are necessary for regulation of HCN4 by LRMP. And we demonstrate that LRMP-regulation can be conferred to HCN2 by addition of the HCN4 N-terminus along with mutation of 5 residues in the S5 region and C-linker to the cognate HCN4 residues. Taken together, these results suggest that LRMP inhibits HCN4 through an isoform-specific interaction involving the N-terminals of both proteins that prevents the transduction of cAMP binding into a change in channel gating via an HCN4-specific orientation of the N-terminus, C-linker, and S4-S5 linker.