Miracle-dz/UniFAR-FTUs huggingface dataset:
Treatment of ADHD in adults – prevalence of discontinuation and associated factors – results from a cross-sectional analysis of Danish register data

Abstract Background A growing number of adults are receiving pharmacological treatment for ADHD but a sizable proportion also discontinues or have gaps in treatment. The primary aims of this study were to identify how many patients treated for ADHD in adulthood, have at least one event of discontinuation in treatment and to identify possible associated variables. Methods Within the Danish population aged 18–60 years on the 1st of January 2013, we identified the number of individuals who had been prescribed ADHD-medication at least once during the 1st of January 2002–31st of December 2013 using Danish register data. Among those who filed more than one prescription, treatment discontinuation was defined as having more than 211 days between two prescriptions. In crude and adjusted logistic regression analysis, we explored potential associations to discontinuation for variables such as gender and age at treatment initiation. Results In a population, if N = 3,165,844 individuals, n = 42,892 had received at least one prescription for ADHD medication. Among those with more than one prescription (N = 38,289), 29.4% had discontinued their treatment at least once, according to our definition of treatment discontinuation. ADHD treatment discontinuation was associated with being male, unemployment, lower educational attainment, receiving incapacity benefits and younger age at treatment initiation (p < 0.001). Conclusions A large proportion of individuals treated for ADHD had at least one discontinuation of treatment according to our definition. Although the present study does not allow for investigating the direction of these effects, nor whether some patients later resumed treatment, having at least one discontinuation was associated with a range of variables relating to e.g. age and gender, and provides an emerging profile for clinicians of patients more likely to discontinue.
A Collaborative Tale of Diagnosing and Treating Chronic Pulmonary Aspergillosis, from the Perspectives of Clinical Microbiologists, Surgical Pathologists, and Infectious Disease Clinicians

Chronic pulmonary aspergillosis (CPA) refers to a spectrum of Aspergillus-mediated disease that is associated with high morbidity and mortality, with its true prevalence vastly underestimated. The diagnosis of CPA includes characteristic radiographical findings in conjunction with persistent and systemic symptoms present for at least three months, and evidence of Aspergillus infection. Traditionally, Aspergillus infection has been confirmed through histopathology and microbiological studies, including fungal culture and serology, but these methodologies have limitations that are discussed in this review. The treatment of CPA requires an individualized approach and consideration of both medical and surgical options. Most Aspergillus species are considered susceptible to mold-active triazoles, echinocandins, and amphotericin B; however, antifungal resistance is emerging and well documented, demonstrating the need for novel therapies and antifungal susceptibility testing that correlates with clinical response. Here, we describe the clinical presentation, diagnosis, and treatment of CPA, with an emphasis on the strengths and pitfalls of diagnostic and treatment approaches, as well as future directions, including whole genome sequencing and metagenomic sequencing. The advancement of molecular technology enables rapid and precise species level identification, and the determination of molecular mechanisms of resistance, bridging the clinical infectious disease, anatomical pathology, microbiology, and molecular biology disciplines.
Cytotoxic Phenanthrene, Dihydrophenanthrene, and Dihydrostilbene Derivatives and Other Aromatic Compounds from Combretum laxum

The chemical investigation of the roots and stems of Combretum laxum yielded a new dihydrostilbene derivative, 4′-hydroxy-3,3′,4-trimethoxy-5-(3,4,5-trimethoxyphenoxy)-bibenzyl (1), two phenanthrenes (2–3), and three dihydrophenanthrenes (4–6), along with one lignan, three triterpenoids, one aurone, one flavone, one naphthoquinone, and two benzoic acid derivatives. Their structures were determined by 1D and 2D nuclear magnetic resonance (NMR) spectroscopic techniques and/or mass spectrometry data. The occurrence of dihydrostilbenoid, phenanthrene and dihydrophenanthrene derivatives is unprecedented in a Combretum species native to the American continent. 2,7-Dihydroxy-4,6-dimethoxyphenanthrene, 2,6-dihydroxy-4,7-dimethoxy-9,10-dihydrophenanthrene and 5-O-methyl apigenin are novel findings in the Combretaceae, as is the isolation of compounds belonging to the chemical classes of aurones and naphthoquinones, while (+)-syringaresinol is reported for the first time in the genus Combretum. Compounds 1–6 were also evaluated for their in vitro cytotoxicity against five human cancer cell lines, and radical-scavenging ability against 1,1-diphenyl-2-picryl-hydrazyl (DPPH). 6-Methoxycoelonin (4) was the most cytotoxic against melanoma cells (IC50 2.59 ± 0.11 µM), with a high selectivity index compared with its toxicity against nontumor mammalian cells (SI 25.1). Callosin (6), despite exhibiting the strongest DPPH-scavenging activity (IC50 17.7 ± 0.3 µM), proved marginally inhibitory to the five cancer cell lines tested, indicating that, at least for these cells, antioxidant potential is unrelated to antiproliferative activity.
Effects of Supplementation with Natural Antioxidants on Oocytes and Preimplantation Embryos

For most infertile couples, in vitro fertilization (IVF) represents the only chance to conceive. Given the limited success of IVF procedures, novel approaches are continuously tested with the aim of improving IVF outcomes. Growing attention is devoted today to the potential benefit of natural antioxidants in the optimization of infertility treatments. This review summarizes current data in this context, focusing on both experimental studies on oocytes/embryos and clinical trials on antioxidants supplementation. Based on information gained from experimental studies, antioxidant supplementation may have beneficial effects on IVF outcomes in terms of quality and cryotolerance of in vitro produced embryos, together with positive effects on in vitro maturation oocytes and on early embryonic development. Unfortunately, from the clinical side, there is a paucity of evidence favoring the protective qualities of antioxidants. Among the antioxidants considered, coenzyme Q10 may be regarded as one of the most promising for its positive role in rescuing the oxidative stress-induced damages, but further data are needed. It is concluded that further trials are necessary to characterize the potential clinical value of antioxidants in IVF treatments.
Performance and Some Blood Chemistry Indices of Broiler Chicken Served Fluted Pumpkin (Telfaria occidentalis) Leaves Extract Supplement

A 56-day experiment involving 120 day-old Anak 2000 broiler chicks was carried out in a completely randomized design to evaluate the performance, haematological parameters and serum metabolites of th e broilers served Fluted Pumpkin Leaves Extract (FPLE) supplement at four days interval for 8 weeks during the late dry season. The birds were allotted to 5 treatments containing 0, 30, 60, 90 and 120 ml FPLE/litre of water. Each treatment was replicated three times. Broiler starters were fed the same starter diet, while the finishers were equally fed the same finisher diet. The FPLE was found to be rich in protein (21.31%) and ash (10.97%) most especially Ca, P, Mg and Fe and relatively low in fibre, tannin and oxalate, hence a good protein and mineral supplement for broilers during the late dry season. Feed intake, body weight gain, feed conversion ratio, water intake, cost of fed per kg live weight gain, haemoglobin, Packed Cell Volume (PCV), Red Blood Cell (RBC), White Blood Cell (WBC), Cholesterol (CH), urea, sodium and potassium of the birds served FPLE were significantly (p<0.05) superior to control. Haemoglobin was elevated on the birds served PFLE by 19.64-48.2% compare to control. The birds served 60 ml FPLE/litre of water had elevated Hb, PCV and RBC, while those on 120 ml had the highest value of WBC, CH and urea. Broiler starters and finishers are recommended to be served 60 and 120 ml FPLE/litre of water, respectively at 4 days interval during late dry season for improved feed intake, weight gain and blood formation.
The significance of multidisciplinary classifications based on transbronchial pathology in possible idiopathic interstitial pneumonias

Abstract Surgical lung biopsy is regarded as the golden standard for the diagnosis of idiopathic interstitial pneumonias (IIPs). Here, we attempted to show the diagnostic accuracy of multidisciplinary classifications based on transbronchial pathology including transbronchial lung cryobiopsy (TBLC) , bronchoalveolar lavage fluid (BALF) and endobronchial ultrasound-guided transbronchial needle aspiration biopsy (EBUS-TBNA). Patients with suspected interstitial lung diseases admitted from June 1, 2016 to December 31, 2018 were involved. Patients with known causes of interstitial lung diseases and typical idiopathic pulmonary fibrosis diagnosed through clinical, radiological information were excluded. Patients with atypical idiopathic pulmonary fibrosis and possible IIPs accepted transbronchial pathological evaluation. Initial multidisciplinary diagnosis (MDD) classifications were made depending on clinical, radiological and transbronchial pathological information by a multidisciplinary team (MDT). The final MDD classifications were confirmed by subsequent therapeutic effects. All patients were followed up for at least 6 months. A total of 70 patients were finally involved. The samples of lung parenchyma extracted through TBLC were enough for confirmation of pathological diagnoses in 68.6% (48/70) cases. Samples of 6 cases were extracted by EBUS-TBNA. Bacteriological diagnoses were positive in 1 case by BALF. Pathological diagnoses of 77.1% (54/70) cases were achieved through TBLC, EBUS-TBNA and BALF. During the follow up study, the pulmonary lesions of 60% patients were improved, 11.43% were relapsed when glucocorticoid was reduced to small dose or withdrawal, 14.29% were leveled off and 8.57% were progressed. The diagnoses of 4 patients with progressed clinical feature were revised. As a result, 94.3% initial MDD classifications based on transbronchial pathology were consistent with the final MDD, and the difference of diagnostic yield wasn’t significant between initial and final MDD (Z = −1.414, P = .157). Classifications of IIPs based on transbronchial pathology were useful and quite agreed with final MDD.
High-Risk Comorbidity Influences Prognosis in Early Gastric Cancer after Noncurative Endoscopic Submucosal Dissection: A Retrospective Study

Background: There are few studies reporting the clinical outcomes of noncurative endoscopic submucosal dissection (ESD) for early gastric cancer (EGC) from the perspective of patient health condition/status. Thus, the aim of this study was to investigate clinical outcomes of noncurative ESD considering not only curability but also patient factors such as advanced age, comorbidities, and nutritional status. Methods: Between April 2007 and March 2012, 95 patients who underwent noncurative ESD for EGC were enrolled in the study. Patients were categorized by treatment after ESD: additional gastrectomy (49 patients) and follow-up (46 patients). Clinical outcomes were evaluated between the 2 groups for overall survival (OS). Results: The absence of lymphovascular involvement and age ≥80 years were significantly associated with decision-making for observation after noncurative ESD. The OS rates were higher in female patients, patients with better Eastern Cooperative Oncology Group performance status (≤1) or low-risk comorbidity (Charlson Comorbidity Index [CCI ≤ 2]), patients with ulcerative findings, and those who underwent radical gastrectomy. Multivariate Cox proportional hazards analysis indicated that presence of a high-risk comorbidity (CCI ≥ 3) was a significant prognostic factor (hazard ratio: 16.43, p = 0.024) in patients who underwent noncurative ESD for EGC. Conclusion: High-risk comorbidity is the primary prognostic parameter in terms of patient factors after noncurative ESD for EGC. The CCI should be considered as a prognostic factor in patients who underwent noncurative ESD for EGC.
A history of systematic studies of the bees of Cuba (Insecta: Hymenoptera, Anthophila)

A meticulous search was made for papers related to Cuban bees to define the historical context and periods in which studies of their taxonomy and natural history have occurred. Systematic studies of this group of insects began 230 years ago. Such studies are divided into several stages: European (1763–1896), North American (1896–1944), consolidation and current (1944–present). I present the current state of knowledge of natural history of Cuban bees, the status of the main entomological collections in the country, and experience in the use of bees as pollinators in Cuba.
Stakeholder perspectives of fall prevention for older Australians with vision impairment: “it’s just a matter of adapting them accordingly”

Abstract Aim To investigate stakeholders’ perspectives of fall prevention programs for older adults with vision impairment. Methods Twenty-two stakeholders (client facing professionals, service managers, and policy makers), with expertise in fall prevention or vision impairment, from organisations in south-eastern Australia, participated in this study. Individual semi-structured interviews were conducted over-the-phone (n = 19) and face-to-face (n = 3), and analysed deductively using content analysis into the following system level factors for health promotion interventions seen within the behaviour change wheel: Fiscal measures; Guidelines; Communication and marketing; and Service provision. Results Five key themes were identified: (1) insufficient guidelines or referral pathways; (2) ongoing funding to secure service delivery and best practice implementation; (3) marketing approach: honouring consumer’s perceptions of themselves; (4) practical suggestions for program delivery; and (5) incorporation into existing services. Stakeholders considered fall prevention for those with vision impairment as essential in preventative healthcare, but did not have a clear understanding of where to refer or how to deliver a fall prevention service for this population. Conclusions This study supports the delivery of fall prevention programs in older adults with vision impairment, but highlights the need to incorporate stakeholder perspectives into the design and delivery of such programs to ensure barriers to implementation in real world settings. Implications for Rehabilitation Older adults with vision impairment are at a high risk of falls but currently have very little access to fall prevention programs. Results support the delivery of fall prevention programs to older adults with vision impairment through existing services, as long as professionals are provided with adequate service delivery guidelines, referral pathways, and fall prevention specific education and professional development opportunities. A variety of service provision, such as group and home-based programs, or using technology, may be cost-effective and improve older adults with vision impairments’ adherence to fall prevention programs.
Progress in microneedle array patch (MAP) for vaccine delivery

ABSTRACT A microneedle array patch (MAP) has been developed as a new delivery system for vaccines. Preclinical and clinical trials with a vaccine MAP showed improved stability, safety, and immunological efficacy compared to conventional vaccine administration. Various vaccines can be delivered with a MAP. Currently, microneedle manufacturers can mass-produce pharmaceutical MAP and cosmetic MAP and this mass-production system can be adapted to produce a vaccine MAP. Clinical trials with a vaccine MAP have shown comparable efficacy with conventional administration, and discussions about regulations for a vaccine MAP are underway. However, there are concerns of reasonable cost, mass production, efficacy, and safety standards that meet FDA approval, as well as the need for feedback regarding the best method of administration. Currently, microneedles have been studied for the delivery of many kinds of vaccines, and preclinical and clinical studies of vaccine microneedles are in progress. For the foreseeable future, some vaccines will continue to be administered with syringes and needles while the use of a vaccine MAP continues to be improved because of the advantages of less pain, self-administration, improved stability, convenience, and safety.
Mediterranean Shrub Diversity and its Effect on Food Intake in Goats

Mediterranean ecosystem offers a variety of shrubs that were over long periods of time involved in the evolution of complex plant-animal interactions. Biochemical components of these plants enter different metabolic pathways after digestion and absorption, resulting in development of dietary preferences in browsing animals. Herbivores in general were found to perform better when grazing in a mixed plant community composed of diverse species, and show preferential feeding behavioure for mixed vs single species diet. Our findings demonstrate an asymptotic relationship among Mediterranean shrubs species diversity and their voluntary intake by goats. Shrub biomass intake showed linear increase when number of different shrubs in diet increased from one to three. However, goats did not further increase intake when the number of shrub species increased from four to eight. As the number of shrub species offered increased, goats exhibited more preferential feeding behaviour for Quercus pubescens, Fraxinus ornus, Rubus heteromorphus and Arbutus unedo and decreased the intake of Hedera helix, Juniperus oxycedrus and Helichrysum italicum. This asymptotic relationship indicates that the maintenance of plant species richness in Mediterranean shrublands can overall benefit domestic goat farming, goat’s productive performance, and the conservation of plant biodiversity.
“When I feel well all over, I study and learn better” - experiences of good conditions for health and learning in schools in the Arctic region of Sweden

ABSTRACT A challenge facing the Arctic region is the disengagement of both education and work among its youth. Only by supporting young people who are struggling with mental and physical health challenges can we begin to address this societal challenge. Education, mental health and social inclusion are prominent factors for future employment, income and independent living for young people. The aim of this study was to describe and understand the experiences of good conditions for health and learning in schools in the Arctic region. The 5-D appreciative inquiry method was used to explore 47 students’ and professionals’ experiences and future visions of their school. A phenomenological analysis resulted in three themes: “Standing as one”, “Having an apple a day”, and “Finding the end of the rainbow”. The findings revealed the necessity of promoting health and learning simultaneously in school and viewing health holistically. Health-promoting relationships permeate the findings of good conditions for health and learning. We argue for considering mandatory health education to increase students’ health literacy and making student participation and staff collaboration a priority in schools in the Arctic region. These findings, their practical implications, and future research directions are discussed.
Neural-Network-Based Event-Triggered Adaptive Control of Nonaffine Nonlinear Multiagent Systems With Dynamic Uncertainties

This article addresses the adaptive event-triggered neural control problem for nonaffine pure-feedback nonlinear multiagent systems with dynamic disturbance, unmodeled dynamics, and dead-zone input. Radial basis function neural networks are applied to approximate the unknown nonlinear function. A dynamic signal is constructed to deal with the design difficulties in the unmodeled dynamics. Moreover, to reduce the communication burden, we propose an event-triggered strategy with a varying threshold. Based on the Lyapunov function method and adaptive neural control approach, a novel event-triggered control protocol is constructed, which realizes that the outputs of all followers converge to a neighborhood of the leader’s output and ensures that all signals are bounded in the closed-loop system. An illustrative simulation example is applied to verify the usefulness of the proposed algorithms.
Integrated Effect of Mineral Fertilizers and Green Manure on Crop Yield and Nutrient Availability under Rice-Wheat Cropping System in Calciorthents

A field experiment conducted on Calciorthents revealed that average biomass production of green gram [Vigna radiata (L.) Wikzek] at initiation of flowering was 1.12 t ha−1 whereas residual yield of green gram was 1.20 t ha−1 after picking pods at full maturity stage. On an average, green gram yielded 0.55 t grain ha−1. The direct and residual effects of 75% NPK + green manure on grain yield of rice and wheat were more than those through addition of 100% NPK, which indicates that green manure could easily substitute 25% NPK to each of rice and wheat crop (equivalent to 25 kg N, 6.67 kg P and 8.3 kg K ha−1 in rice-wheat cropping system). Green manuring and green gram residue incorporation enhanced the uptake of N, P and K by rice and wheat. The direct and residual effect of green gram residues incorporation was inferior to green manuring because of high C/N ratio of the crop residue (34.3). Significant build up of organic carbon, available N, P and K in soils was recorded under graded levels of fertilizers and also with green manure and green gram straw incorporation after the picking of pods. This study suggests that a short duration pulse crop like green gram can give dual profit by way of providing grain for sale/consumption by the farmer's family and straw as the green manure.
Effects of Cow Green Reservoir upon downstream fish populations

Post impoundment observations on the fish populations of the River Tees, downstream from the Cow Green Reservoir were made between 1971 and 1980. Both bullhead (Cottus gobio L.) and brown trout (Salmo trutta L.) population densities increased in the river after impoundment but changes in growth rate were small. Investigations into the stomach contents of the two species reflects the results of other work on increases of benthos in the river. Following regulation there was an increase in the quantity of Ephemerella ignita found in trout stomachs while in the bullhead, regulation caused an increase in the importance of Mollusca and a decrease in importance of Ephemeroptera and Plecoptera.
INCOMPLETE SIMIAN PAPOVAVIRUS SV40

A study was made of the effects of 5-fluorouracil (FU) and 5-fluorodeoxyuridine (FUDR) on the replication of the simian papovavirus SV40 in cercopithecus monkey kidney cells and on the production of virus antigen by these cells. Both drugs markedly suppressed the production of new infectious virus by SV40-infected cells. Synthesis of viral protein was also markedly suppressed by FUDR, but not by FU. In the presence of FU, infected cells produced large amounts of viral protein which were detected by the fluorescent antibody technique. The antigen was not distributed in a particulate fashion as in untreated cells. Diffuse virus antigen was observed in the nuclei of FU-treated cells, resembling the distribution of antigen near the end of the eclipse period in untreated, infected cultures. This stage of antigen production presumably preceded viral assembly. Virus particles with or without cores were rarely seen with the electron microscope in infected FU-treated cells, although large numbers of SV40 particles were readily visualized in untreated, infected cells. It appears that at least one antigenic protein of this papovavirus is synthesized abundantly in FU-treated cells, but is not assembled into virus shells in the presence of the inhibitor.