Miracle-dz/UniFAR-FTUs huggingface dataset:
Magnetic Resonance Imaging or Ultrasound in Localized Intermediate- or High-Risk Soft Tissue Tumors of the Extremities (MUSTT): Final Results of a Prospective Comparative Trial

Objectives: To report final results of the MUSTT trial, which has been designed to independently compare magnetic resonance imaging (MRI) and ultrasound (US) for local recurrences of non-metastatic patients operated for malignant soft tissue tumors (STT). Methods: Magnetic resonance imaging or ultrasound in soft tissue tumors (MUSTT) is a prospective monocentric study recruiting asymptomatic, non-metastatic patients operated on for localized soft tissue sarcomas between 2015 and April. Eligible patients had MRI and physician-performed ultrasound (US) with an independent interpretation of imaging. Outcome measures were compared using ROC analysis and the X2 test. An analysis of all patients was performed on a per-follow-up event basis. Results: A total of n = 51 patients who met the inclusion criteria agreed to participate. Among them, n = 8 were lost to follow-up, n = 6 had US and MRI acquired after a time frame > 7 days and were therefore excluded. Complete data available for 37 patients with 232 MRI and 232 US scan were finally considered (men/women: 18/20; age range, 18–84 years). Recurrences within 5 years occurred in 10/37 patients (27%). ROC analysis comparing US and MRI showed an AUC with 95% confidence intervals of 0.909 (0.832 to 0.981) for US and 0.966 (0.939 to 0.989) for MRI with Prob > X2 = 0. Conclusions: Each of these tests detected local recurrences with suitable accuracy. MRI did not result clearly superior to US in terms of diagnostic accuracy, but US showed some false positive or negative results.
Social-Ecological Analysis of the Sport and Recreation Programs’ Impacts on Positive Development of Youth from Socially Vulnerable Backgrounds

ABSTRACT Positive developmental experiences of youth from socially vulnerable backgrounds in sport and recreation programmes have a capacity to contribute to youth’s resilience and serve as protective factors. Nevertheless, this area is under-researched and poorly understood. The purpose of this study was to address this gap by investigating the effects of sport and recreation programmes on lives and positive development of youth from socially vulnerable backgrounds. Drawing upon constructivist grounded theory, the data collection involved 13 interviews with practitioners and volunteers working with this population. The data were analysed inductively using initial, focused, and theoretical coding, whereas the latter involved the Social-Ecological Model and Positive Youth Development approach to conceptualise the multidimensional and dynamic interrelationships between individuals and the social ecology of positive development. The findings reveal the programmes’ impacts on personal (social-emotional skills), interpersonal (prosocial relationships), school (support systems), community/neighbourhood (sense of citizenship), and societal levels (norms and policies) that can facilitate healthy developmental outcomes of those who face developmental challenges. This study contributes to the understanding of the multi-level capacity of sport and recreation programmes to promote positive development among youth from socially vulnerable backgrounds and offers valuable insights for the programmatic design and delivery.
Simultaneous Estimation of Unknown Road Roughness Input and Tire Normal Forces Based on a Long Short-Term Memory Model

This paper reports an initial study on the simultaneous estimation of unknown road roughness input and tire normal forces for automotive vehicles using a long short-term memory (LSTM) model. Active safety systems and the improvement of ride comfort using vehicle information have garnered increasing attention in the automotive industry. In particular, active safety systems rely significantly on road roughness data and the normal force of the tires. If these factors can be measured in real-time for a driving vehicle, the measured data can be used for automotive control systems for tasks, such as semi-active and active suspension control, rolling motion control, and torque vectoring. However, it is typically difficult to measure the road roughness and tire normal force directly in real-time by mounting physical sensors on the vehicle. In this study, we explore the simultaneous estimation of these factors using an LSTM model that requires only time-series data of the vehicle body. The LSTM model is implemented by using MATLAB/Simulink and includes data preprocessing, learning, and verification steps. To evaluate the estimation performance of the LSTM model, we compared it with a Kalman filter and used CarSim vehicle simulation software to simulate and interpret the dynamic behavior of vehicles.
Inflammation Status and Body Composition Predict Two-Year Mortality of Patients with Locally Advanced Head and Neck Squamous Cell Carcinoma under Provision of Recommended Energy Intake during Concurrent Chemoradiotherapy

Only few prospective cohort trials have evaluated the risk factors for the 2-year mortality rate between two patient subgroups with locally advanced head and neck squamous cell carcinoma (LAHNSCC): oral cavity cancer with adjuvant concurrent chemoradiotherapy (CCRT) (OCC) and non-oral cavity cancer with primary CCRT (NOCC), under the recommended calorie intake and investigated the interplay among calorie supply, nutrition–inflammation biomarkers (NIBs), and total body composition change (TBC), as assessed using dual-energy X-ray absorptiometry (DXA). Patients with LAHNSCC who consumed at least 25 kcal/kg/day during CCRT were prospectively recruited. Clinicopathological variables, blood NIBs, CCRT-related factors, and TBC data before and after treatment were collected. Factor analysis was performed to reduce the number of anthropometric and DXA-derived measurements. Cox proportional hazards models were used for analysis. We enrolled 123 patients with LAHNSCC (69 with OCC and 54 with NOCC). The mean daily calorie intake correlated with the treatment interval changes in total body muscle and fat. Patients consuming ≥30 kcal/kg/day had lower pretreatment levels but exhibited fewer treatment interval changes in anthropometric and DXA measurements than patients consuming <30 kcal/kg/day. In the multivariate analysis of the 2-year mortality rate, the prognostic influence of the recommended calorie intake could not be confirmed, but different risk factors (performance status, pretreatment platelet-to-lymphocyte ratio, and treatment interval body muscle changes in patients with OCC; age, pretreatment neutrophil-to-lymphocyte ratio, and body fat storage in patients with NOCC) showed independent effects. Therefore, the inflammation status and body composition, but not the recommended calorie supply, contribute to the 2-year mortality rate for patients with LAHNSCC receiving CCRT.
Effectiveness of Physical Activity in Primary Prevention of Anxiety: Systematic Review and Meta-Analysis of Randomized Controlled Trials

The aim of this study was to evaluate the effectiveness of physical activity in the primary prevention of anxiety. A systematic review of randomized controlled trials (RCTs) was performed. RCTs were searched in seven electronic databases. We included RCTs that assessed either the incidence of anxiety or the reduction of anxiety symptoms which excluded participants with baseline anxiety. Measurements were required to have been made using validated instruments. Objective or subjective (with validated questionnaires) verification of the performance of physical activity was required. Three reviewers carried out the search, selection, data extraction, and risk assessment of Cochrane Collaboration’s tool simultaneously and independently, reaching an agreement in their discrepancies by consensus. In addition, a meta-analysis of fixed-effects model was carried out. Three RCTs met inclusion criteria, comprising 350 patients from 3 different countries. A meta-analysis was performed using five comparisons extracted from the selected studies, and the pooled standardized mean difference (SMD) was −0.18 (95% CI: −0.44; 0.07), p = 0.158. The heterogeneity was irrelevant, I2 = 17.7% (p = 0.30). There is no evidence that anxiety can be prevented through physical activity, although the quality of evidence was very low.
A Vital Signs Fast Detection and Extraction Method of UWB Impulse Radar Based on SVD

The identification of weak vital signs has always been one of the difficulties in the field of life detection. In this paper, a novel vital sign detection and extraction method with high efficiency, high precision, high sensitivity and high signal-to-noise ratio is proposed. Based on the NVA6100 pulse radar system, the radar matrix which contains several radar pulse detection signals is received. According to the characteristics of vital signs and radar matrices, the Singular Value Decomposition (SVD) is adopted to perform signal denoising and decomposition after preprocessing, and the temporal and spatial eigenvectors of each principal component are obtained. Through the energy proportion screening, the Wavelet Transform decomposition and linear trend suppression, relatively pure vital signs in each principal component, are obtained. The human location is detected by the Energy Entropy of spatial eigenvectors, and the respiratory signal and heartbeat signal are restored through a Butterworth Filter and an MTI harmonic canceller. Finally, through an analysis of the performance of the algorithm, it is proved to have the properties of efficiency and accuracy.
Women Specific Characteristics and 1-Year Outcome Among Patients Hospitalized for Peripheral Artery Disease: A Monocentric Cohort Analysis in a Tertiary Center

Although women have lower age-standardized cardiovascular disease incidence, prevalence, and death-related rates than men, there are also reports indicating that women with cardiovascular disease receive less care, fewer investigations, and have poorer outcomes after a coronary event. The aims of this study were to compare the characteristics of men and women hospitalized for peripheral artery disease (PAD), their cardiovascular and limb outcomes, and their 1-year mortality. The study is a prospective registry collecting data about all consecutive patients hospitalized for PAD within the vascular department of the tertiary center Georges-Pompidou European Hospital (Paris, France). Patients were required to have one of three inclusion criteria: previous revascularization of the lower limb or any lower limb artery occlusion due to an atherosclerotic vascular disease or hemodynamic evidence of PAD. Exclusion criteria were patients with lower extremity arterial occlusion due to another cause. All patients were followed-up for at least 12 months after the initial hospitalization. Among the 235 patients included, there were 61 women (26%), older than men with a median age of 75.6 and 68.3 years, respectively. Main cardiovascular risk factors and comorbidities were similar for men and women except more former or current smokers [145 (83.4%) vs. 33 (54.1%)] and more history of coronary heart disease [42 (24.1%) vs. 7 (11.5%)] in men. Most patients [138 (58.8%)] had critical limb ischemia and 97 (41.3%) had claudication, with no difference for sex. After discharge, 218 patients received an antithrombotic therapy (93.2%), 195 a lipid-lowering drug (83.3%), 185 an angiotensin converting enzyme inhibitor or angiotensin-receptor blocker (78.9%), similarly between sex. At 1-year, overall mortality, major adverse cardiovascular events, major adverse limb events did not differ with 23 (13.2%), 11 (6.3%) and 32 (18.4%) in men, and 8 (13.1%), 3 (4.9%), 15 (24.6%) in women, respectively, despite the difference in age. Overall mortality, cardiovascular outcomes, limb revascularization or amputation did not differ between men and women, 1-year after hospitalization for PAD although the latter were older, less smoker and had less coronary artery disease. Due to the small size of this cohort, larger studies and future research are needed to better understand sex-specific mechanisms in the pathophysiology and natural history of PAD.
Evaluating the effectiveness of ‘mentoring to be active’ for rural Appalachian middle school youth on physical activity and dietary sugar consumption during ‘out of school’ time

ABSTRACT Appalachian youth are highconsumers of added dietary sugar and are very sedentary. Mentoring to be Active trains teens to deliver atheoretically based program to promote home-based physical activity (PA) and reduce dietary sugar among rural Appalachian youth. For this pre-test/post-test pilot study, 52 seventh graders from two Appalachian schools participated as mentees. Twenty-two 10th grade students served as peer mentors. The study estimated sedentary activity,and physical activity by accelerometers and dietary sugars (snacks, beverages) during ‘out of school’ time. Descriptive statistics and effect sizes (ES) were calculated. When the pre-post standard deviations differed, Hedge’s g were reported. Sedentary activity decreased 36.7% (ES = .798). Moderate activity levels increased 16.5% (ES = .359). Vigorous activity increased 88% (ES = .359). Sugary- beverages declined over 4 ½ servings. Sugary snacks declined 2 ¼ servings. Peer mentoring is a strategy to promote social support for healthier behaviors among youth at risk for obesity and co-morbidities. Accelerometers rigorously assessed physical activity during ‘out of school’ time in rural youth.
Fullerene Derivative with Flexible Alkyl Chain for Efficient Tin-Based Perovskite Solar Cells

Fullerene derivatives are considered excellent materials for the extraction and transportation of electrons in the production of efficient tin-based perovskite solar cells (TPSCs). However, it is not clear how the molecular structure of fullerene derivatives affects the efficiency and stability of TPSCs. In this study, the effects of fullerene derivatives, (6,6)-phenyl-C61-butyric acid hexyl ester (PCBH) and (6,6)-phenyl-C61-butyric acid methyl ester (PCBM), with different functional groups, on photovoltaic performance were investigated. The flexible alkyl chain of PCBH effectively improved the film morphology and stability, the electron extraction and transport capabilities, and the interface contact of fullerene and perovskite. As a result, the PCBH-based TPSC yielded a higher efficiency, of 9.21%, than the PCBM-based devices (7.54%). More importantly, the PCBH-based films exhibited higher stability and effectively suppressed the oxidation of Sn2+ by inhibiting oxygen permeation. Therefore, the PCBH-based devices exhibited significantly enhanced stability. This result indicates that optimizing the functional group of fullerene derivatives is crucial for improving the efficiency and stability of TPSCs.
Characterization of a Novel Mycovirus from the Phytopathogenic Fungus Botryosphaeria dothidea

Botryosphaeria dothidea is, globally, one of the most economically important phytopathogenic fungi worldwide, causing the canker and dieback of fruit trees. An increasing number of viruses infecting B. dothidea have lately been reported, several of which could confer hypovirulence. In this study, isolated from strain ZM170285-1 of B. dothidea, a novel double-stranded RNA (dsRNA) mycovirus, tentatively named Botryosphaeria dothidea partitivirus 2 (BdPV2), was identified well. The BdPV2 harbored three dsRNA segments (1–3) with lengths of 1751, 1568, and 1198 bp, which encoded an RNA-dependent RNA polymerase (RdRp), a capsid protein (CP), and a hypothetical protein of unknown function, respectively. BLASTp searches revealed that the predicted protein sequences of dsRNA1 and dsRNA2 had the highest identities (74.95% and 61.01%) with the corresponding dsRNAs of Penicillium stoloniferum virus S (PsV-S), whereas dsRNA3 shared the highest identity (32.95%) with the dsRNA3 of Aspergillus ochraceous virus 1 (AoV1). Phylogenetic analysis indicated that BdPV2 belonged to the Gammapartitivirus genus and Partitiviridae family. To our knowledge, this is the first report of a Gammapartitivirus in B. dothidea.
The Effect of Static Compression via Vibration Foam Rolling on Eccentrically Damaged Muscle

Previous research has shown that vibration foam rolling (VFR) on damaged muscle can result in improvements in muscle soreness and range of motion (ROM). Furthermore, static compression via VFR (i.e., VFR without rolling) can increase the ROM and decrease the muscle stiffness of non-damaged muscle. Therefore, it is likely that static compression via VFR on eccentrically damaged muscle can mitigate muscle soreness and the decrease in ROM, and the decrease in muscle strength. The purpose of this study was to investigate the acute effects of a 90 s bout of VFR applied as a static compression on an eccentrically damaged quadriceps muscle, measuring ROM, muscle soreness, muscle strength, and jump performance. This study was a single-arm repeated measure design. Study participants were sedentary healthy male volunteers (n = 14, 20.4 ± 0.8 years) who had not performed habitual exercise activities or any regular resistance training for at least 6 months before the experiment. All participants performed a bout of eccentric exercise of the knee extensors with the dominant leg and then received a 90 s bout of static compression via VFR of the quadriceps 48 h after the eccentric exercise. The knee flexion ROM, muscle soreness at palpation, and countermovement jump height were measured before the eccentric exercise (baseline), before (pre-intervention) and after the VFR intervention (post-intervention), and 48 h after the eccentric exercise. The results showed that the static compression via VFR significantly (p < 0.05) improved the knee flexion ROM (6.5 ± 4.8%, d = 0.76), muscle soreness at palpation (−10.7 ± 8.6 mm, d = −0.68), and countermovement jump height (15.6 ± 16.0%, d = 0.49). Therefore, it can be concluded that static compression via VFR can improve muscle soreness and function.
Automated Lung Sound Classification Using a Hybrid CNN-LSTM Network and Focal Loss Function

Respiratory diseases constitute one of the leading causes of death worldwide and directly affect the patient’s quality of life. Early diagnosis and patient monitoring, which conventionally include lung auscultation, are essential for the efficient management of respiratory diseases. Manual lung sound interpretation is a subjective and time-consuming process that requires high medical expertise. The capabilities that deep learning offers could be exploited in order that robust lung sound classification models can be designed. In this paper, we propose a novel hybrid neural model that implements the focal loss (FL) function to deal with training data imbalance. Features initially extracted from short-time Fourier transform (STFT) spectrograms via a convolutional neural network (CNN) are given as input to a long short-term memory (LSTM) network that memorizes the temporal dependencies between data and classifies four types of lung sounds, including normal, crackles, wheezes, and both crackles and wheezes. The model was trained and tested on the ICBHI 2017 Respiratory Sound Database and achieved state-of-the-art results using three different data splitting strategies—namely, sensitivity 47.37%, specificity 82.46%, score 64.92% and accuracy 73.69% for the official 60/40 split, sensitivity 52.78%, specificity 84.26%, score 68.52% and accuracy 76.39% using interpatient 10-fold cross validation, and sensitivity 60.29% and accuracy 74.57% using leave-one-out cross validation.
Benefits of Telemonitoring of Pulmonary Function—3-Month Follow-Up of Home Electronic Spirometry in Patients with Duchenne Muscular Dystrophy

Background: In patients with Duchenne Muscular Dystrophy (DMD), the respiratory system determines the quality and length of life; therefore, the search for easy and safe everyday monitoring of the pulmonary function is currently extremely important, particularly in the COVID-19 pandemic. The aim of the study was to evaluate the influence of a three-month home electronic spirometry (e-spirometry) monitoring of the pulmonary function and strength of respiratory muscles as well as the patients’ benefits from this telemetric program. Methods: Twenty-one boys with DMD (aged 7–22; non-ambulatory-11) received a remote electronic spirometer for home use with a special application dedicated for patients and connected with a doctor platform. Control of the hospital spirometry (forced vital capacity-FVC, forced expiratory volume in 1 second-FEV1, peak expiratory flow-PEF) and respiratory muscle strength (maximal inspiratory-MIP and expiratory pressures-MEP) before and after the three-month monitoring were performed as well telemonitoring benefit survey. Results: A total of 1403 measurements were performed; 15 of the participants were able to achieve correct attempts. There were no differences between the hospital and the home spirometry results as well as between respiratory muscle strength during v1 vs. v2 visits for the whole study group (all parameters p > 0.05); the six participants achieved increased value of FVC during the study period. There was a positive correlation between ΔFVC and the number of assessments during the home spirometry (r = 0.7, p < 0.001). Differences between FVC and MIPcmH2O (r = 0.58; p = 0.01), MEPcmH2O (r = 0.75; p < 0.001) was revealed. The mean general satisfaction rating of the telemonitoring was 4.46/5 (SD 0.66) after one month and 4.91/5 (SD 0.28) after three months. The most reported benefit of the home monitoring was the improvement in breathing (38% of participants after one month, 52% after three months of telemonitoring). Forgetting about the procedures was the most common reason for irregular measurements; the participants reported also increased motivation but less time to perform tests. Conclusions: The study indicates high compliance of the home telemonitoring results with the examination in the hospital. Benefits from home spirometry were visible for all participants; the most important benefit was breathing improvement. The remote home spirometry is usable for everyday monitoring of the pulmonary function in DMD patients as well can be also treated as respiratory muscle training.
Observability Analysis Based on QR Decomposition and Adaptive Information Fusion Mechanism for Low-Cost Multi-Rotor UAVs

This paper proposes a novel observability analysis method with less computation, which is based on QR decomposition and is suitable for low-cost devices with limited computing power. On this basis, an adaptive information fusion mechanism (AIFM) based on the criteria from the degree of observability (DOO) for the traditional extended Kalman filter (EKF) is designed to improve the tolerance of the integrated navigation system against time-varying observation conditions. Theoretical analysis and experimental results illustrate that the proposed observability analysis method can effectively evaluate each state variable’s observability, whose computational complexity is significantly reduced by 93.07% (the size of stripped observability matrix is $105\times15$ ) compared with the conventional method based on singular value decomposition (SVD). Moreover, the simulation and real-world experiment results show that the AIFM makes the navigation system more robust by automatically updating the state variables’ weights according to their observability, which also enhances the reliability of the horizontal attitude angle estimation with excellent efficiency since they are given top priority in our fusion mechanism. In conclusion, our method is practical to improve the integrated navigation system’s accuracy, robustness, and fault-tolerance ability in complex and dynamic environments, suggesting that this technique is viable for multi-rotor navigation and control applications.