Miracle-dz/UniFAR-FTUs huggingface dataset:
An Investigation into the Effect of Listening to the Voice of the Holy Quran on Vital Signs and Consciousness Level of Patients Admitted to the ICU Wards of Zabol University of Medical Sciences Hospitals

Introduction: Recent advances in medical sciences have increased the survival rate of injured patients and led to hospitalization of patients for a long time in the ICU wards. Patients admitted to special wards are confronted with considerable stress. Tension is usually associated with an increase in metabolic rate and, consequently, an increase in body temperature, in cardiac output and cardiac contractility, an increase in blood pressure, heart rate and respiratory rate. Therefore, the aim of this study was to investigate the helping effect of voice of the Quran on vital signs and level of consciousness in the patients admitted to the ICU wards”. Materials and Methods: This study was a clinical trial. Thirty subjects were selected through random sampling method. For 10 consecutive days, Yousef Sura was played through a headphone for 15 minutes daily, and then physiological parameters, including systolic and diastolic blood pressure, respiration, pulse, and consciousness level were recorded by physiological indexes in two rounds, The first turn was 5 minutes before playing the Quran voice and the second one was immediately measured after completion of the Holy Quran broadcast. SPSS software version 22 was used to analyze the data. Findings: Based on the results between the vital signs before and after the intervention, significant differences were observed (p <0.0001) in that the rate of vital signs declined after intervention. Additionally, there was a significant difference between the level of consciousness before and after the intervention (p <0.0001), increasing the level of consciousness after the intervention. Conclusion: The results of this study show the effect of Quran verses on reducing vital signs and increasing the level of consciousness. Considering this easy and cost-free method, it can be used to provide an effective step in improving the conditions of patients admitted to special wards and for other patients suffering from tension and instability of vital signs due to various causes.
Prevalence of Thyroid Dysfunction among Type 2 Diabetic Patients (T2D) in Makkah and Jeddah, KSA

Background: The association between diabetes mellitus (DM) and thyroid dysfunction is well known. However, the prevalence of having DM with thyroid dysfunction is extremely variable from one study to another. Clinical relevance of thyroid disorders in diabetic patients leads to serious consequences with metabolic compensation of diabetes. Objectives: to find the prevalence of thyroid dysfunction in T2D retrospectively through the data available in our diabetic centers among those who attended the diabetic clinics for routine checkup. Patients and methods: This is a retrospective cohort study conducted from January to August 2017 at three diabetic centers in Makkah and Jeddah, Kingdom of Saudi Arabia. Nine hundred and seventy-nine patients aged between 30 and 65years, of both genders with T2D were randomly selected. The participants` data were collected from their files, using a data collection checklist prepared for the study. Results: The study included 979 T2D patients. The prevalence of thyroid dysfunction among T2D patients was 13.1%. Mean age amongT2D patients with thyroid dysfunction was 48.8 years whereas the mean age among T2D patients with hypertension was 58.5 years. Females were significantly more presented with T2D and thyroid dysfunction. Again, T2D associated with thyroid dysfunction and hypertension was significantly more in females than males. Duration of diabetes was significantly more among patients having T2D, thyroid dysfunction and hypertension than those with only T2D and thyroid dysfunction. Oral antidiabetics (OADs) were more frequently used than combination of OADs and insulin while diet and exercise only were less, however thyroid dysfunction was more among them. Majority of our participants with T2D and thyroid dysfunction reported the occurrence of T2D first Conclusion: The prevalence of thyroid disorder is quite high amongT2D patients. Prevalence was higher in female patients and relatively younger ages. Early detection of thyroid dysfunction in patients with T2Dis of great importance and consequences.
ACSL3 is a novel GABARAPL2 interactor that links ufmylation and lipid droplet biogenesis

ABSTRACT While studies of the autophagy-related (ATG) genes in knockout models have led to an explosion of knowledge about the functions of autophagy components, the exact roles of LC3 and GABARAP family proteins (human ATG8 equivalents) are still poorly understood. A major drawback in understanding their roles is that the available interactome data has largely been acquired using overexpression systems. To overcome these limitations, we employed CRISPR/Cas9-based genome-editing to generate a panel of cells in which human ATG8 genes were tagged at their natural chromosomal locations with an N-terminal affinity epitope. This cellular resource was employed to map endogenous GABARAPL2 protein complexes using interaction proteomics. This approach identified the ER-associated protein and lipid droplet (LD) biogenesis factor ACSL3 as a stabilizing GABARAPL2-binding partner. GABARAPL2 bound ACSL3 in a manner dependent on its LC3-interacting regions, whose binding site in GABARAPL2 was required to recruit the latter to the ER. Through this interaction, the UFM1-activating enzyme UBA5 became anchored at the ER. Furthermore, ACSL3 depletion and LD induction affected the abundance of several ufmylation components and ER-phagy. Together these data allow us to define ACSL3 as a novel regulator of the enigmatic UFM1 conjugation pathway. Highlighted Article: Using endogenous tagging and interaction proteomics, we identified the ER-associated lipid droplet biogenesis factor ACSL3 as a GABARAPL2-binding partner that serves as novel regulator of the enigmatic UFM1 conjugation pathway.
Knowledge Management Practices as a Source of a Firm’s Potential and Realized Absorptive Capacity

Abstract This paper aims to assess the connections between knowledge management practices and a firm’s potential and realized absorptive capacities. We use hierarchical multiple regression to test our theoretical framework using survey data collected from 94 Russian firms. By critically reviewing the antecedents of particular absorptive capacity subsets at the managerial, intra-organizational and inter-organizational levels, our study reveals the key knowledge management practices—work organization, information technologies, learning mechanisms, training and development and strategic management of knowledge—that enhance a firm’s ability to acquire and assimilate knowledge (potential absorptive capacity) and to transform and exploit knowledge (realized absorptive capacity).
Compound 49b Reduces Inflammatory Markers and Apoptosis after Ocular Blast Injury

Abstract : In year 3 of the Award we have extended our work to finalize the testing of Compound 49b in the IGBP-3 pathway in a trauma model. Specifically, we have done experimentation on how the inflammatory signaling pathway of TNF-alpha interacts with IGFBP-3 signaling in the blast model. As part of the PI transition, we extended our studies into the systemic effects of Compound 49b after ocular blast injury and successfully generated a method for the isolation of retinal ganglion cells, which are critical for the visual output from the eye to the brain in health and ocular injury.
No Association between HPV Vaccination and Infertility in U.S. Females 18-33 Years Old

Background: Human papillomavirus (HPV) vaccines have been recommended as primary prevention of HPV-related cancers for over 10 years in the United States, and evidence reveals decreased incidence of HPV infections following vaccination. However, concerns have been raised that HPV vaccines could decrease fertility. This study examined the relationship between HPV immunization and self-reported infertility in a nationally representative sample. Methods: Data from the 2013-2016 National Health and Nutrition Examination Survey were analyzed to asses likelihood of self-reported infertility among women aged 20 to 33, who were young enough to have been offered HPV vaccines and old enough to have been queried about infertility (n=1,114). Two logistic regression models, stratified by marital history, examined potential associations between HPV vaccination and infertility. Model 1 assessed the likelihood of infertility among women who had never been pregnant or whose pregnancies occurred prior to HPV vaccination. Model 2 accounted for the possibility of latent and/or non-permanent post-vaccine infertility by including all women 20-33 years old. Results: 8.1% reported any infertility. Women who had ever been married and had received an HPV vaccine were less likely to report infertility (OR 0.04, 95% CI 0.01-0.57) in model 1. No other associations between HPV and infertility were found. Conclusion: There was no evidence of increased infertility among women who received the HPV vaccine. These results provide further evidence of HPV vaccine safety and should give providers confidence in recommending HPV vaccination. Further research should explore protective effects of HPV vaccines on female and male fertility. What is already known on this subject? Despite evidence that HPV vaccines are safe and effective, concerns persist regarding a purported link between HPV vaccination and infertility. These concerns were refuted by a recent population-based cohort study that found no association between the HPV vaccine and primary ovarian insufficiency. What this study adds? This study broadens the existing evidence by exploring possible associations between HPV vaccination and any self-reported infertility. There was no evidence of infertility among women 20-33 years old who received one or more doses of HPV vaccine. This result provides further evidence of HPV vaccine safety, diminishing remaining concerns among clinicians and the public.
Bioimpedance-Based Heart Failure Deterioration Prediction Using a Prototype Fluid Accumulation Vest-Mobile Phone Dyad: An Observational Study

Background Recurrent heart failure (HF) events are common in patients discharged after acute decompensated heart failure (ADHF). New patient-centered technologies are needed to aid in detecting HF decompensation. Transthoracic bioimpedance noninvasively measures pulmonary fluid retention. Objective The objectives of our study were to (1) determine whether transthoracic bioimpedance can be measured daily with a novel, noninvasive, wearable fluid accumulation vest (FAV) and transmitted using a mobile phone and (2) establish whether an automated algorithm analyzing daily thoracic bioimpedance values would predict recurrent HF events. Methods We prospectively enrolled patients admitted for ADHF. Participants were trained to use a FAV–mobile phone dyad and asked to transmit bioimpedance measurements for 45 consecutive days. We examined the performance of an algorithm analyzing changes in transthoracic bioimpedance as a predictor of HF events (HF readmission, diuretic uptitration) over a 75-day follow-up. Results We observed 64 HF events (18 HF readmissions and 46 diuretic uptitrations) in the 106 participants (67 years; 63.2%, 67/106, male; 48.1%, 51/106, with prior HF) who completed follow-up. History of HF was the only clinical or laboratory factor related to recurrent HF events (P=.04). Among study participants with sufficient FAV data (n=57), an algorithm analyzing thoracic bioimpedance showed 87% sensitivity (95% CI 82-92), 70% specificity (95% CI 68-72), and 72% accuracy (95% CI 70-74) for identifying recurrent HF events. Conclusions Patients discharged after ADHF can measure and transmit daily transthoracic bioimpedance using a FAV–mobile phone dyad. Algorithms analyzing thoracic bioimpedance may help identify patients at risk for recurrent HF events after hospital discharge.
Deep in-situ learning for object recognition

T his dissertation is about in-situ object recognition, meaning that specific objects (instances) can be learned from a few training examples that depict them within the place where such objects are commonly present or being used. Learning to recognize objects in-situ opposes to conventional approaches in deep learning of relying on largescale class-level datasets of grouped instances, utilizing complex image acquisition setups or utilizing synthetic data. We aim for a scalable, robust, and real-time system based on Convolutional Neural Networks (CNNs) that learn discriminative features from images depicting objects from an egocentric point of view. We are particularly interested in learning objects from a few examples taken directly by an agent or by a demonstrator, and where the CNN does not need a finetuning process for learning additional instances, motivated by the computational limitations in most autonomous platforms. We hope our approach will be helpful for robotic tasks such as object manipulation, human-robot interaction, semantic mapping, scene understanding, autonomous navigation, and contribute to FARSCOPE’s vision on advancing the state-of-the-art of autonomy in robots and intelligent systems.
Bridging the Generational Gap in the Hospitality Industry: Reverse Mentoring—An Innovative Talent Management Practice for Present and Future Generations of Employees

In the present generational context, talent management approaches and practices have evolved from the stage of “war for talent”, defined by competitiveness and elitism, to a more collaborative and inclusive “post-war stage”. Innovative solutions are increasingly important. In this framework, the main aim of the paper is to confirm that reverse mentoring, a talent management practice which appeared as a response to the necessity to bridge the present generational gap, can be considered a valuable approach in hospitality. Two case studies on the successful implementation of reverse mentoring in Swiss hospitality are presented: the Shadow Comex (Accor) and the ExCom-Y (Mövenpick). Results of a focus-group discussion on the topic of identifying the attitudes and opinions of Romanian employees regarding the implementation of reverse mentoring in hotels are further analyzed. Results support the idea that reverse mentoring has developed and offers great potential for innovation. The present study offers interesting and useful ideas to companies in hospitality on how to implement reverse mentoring. Results from the group discussion demonstrate that Romanian employees have high expectations and innovative approaches regarding the implementation of reverse mentoring, similar to the employees from Switzerland, but they lack trust in their employers regarding the real possibility to implement it.
A Goals-Based Theory of Utility

Abstract Theoretical frameworks to date have prescribed how an investor should allocate wealth within mental accounts. However, there is no fully cohesive solution to prescribe how an investor should rationally allocate resources across mental accounts. It is the aim of this discussion to fill that theoretical gap. We present a framework which can be used to rationally allocate resources both within and across mental accounts or goals. We then compare and contrast this method with mean-variance optimization and behavioral portfolio theory, showing that both are stochastically dominated by the goals-based utility framework. In further analysis of empirical validity, we discuss the Samuelson Paradox, Friedman-Savage puzzle, and probability weighting functions.
The Effects of Substrate Oxidation on Post-exercise Food Intake in Pre-pubertal, Normal-weight Boys and Men

The relationship between substrate oxidation (RER) and food intake (FI) is undefined. This study examined the effects of RER modified by a glucose pre-load (GL), exercise (EX) and GL with EX on, FI and energy balance (NEB) in normal-weight boys (9-12 y) and men (20-30 y). Subjects (15 boys, 15 men) were randomized with treatments of either water or GL followed by either EX or rest. Measures included RER, energy expenditure (EE)(kcal/kg), subjective appetite, FI(kcal/kg) measured at a pizza lunch and NEB (kcal/kg). FI(kcal/kg) was reduced by GL(p < 0.0001), and further decreased with GL ingested prior to EX(p = 0.0254). RER was increased with GL(p < 0.0001) and EX(p = 0.0043), and was higher in men compared to boys (p = 0.007). There was no association between RER and FI(kcal/kg). In conclusion, there was no relationship between RER and FI, suggesting that FI is not affected by substrate oxidation.
The side effect of Botulinum toxin A injection for position of the eyelid

Authors report about a case illustrating the possibility of negative influence of repeated application of a derivate of Botulutoxin A on the eyelid position in older woman. The indication for successful surgical treatment was chronic entropium of lower lid. This was initially ineffectively treated by means of repeated intradermal injections of in this neurotoxin. Histological examination of the excised skin and subcutis samples taken during entropium plastic surgery showed unfavorable and irreversible changes including especially scarring of the eyelid and atrophy of the stripped muscles. Always we have to consider the frequency of application, because repeatedly used derivate of this neurotoxine causes irreversible changes in cutaneous and subcutaneous tissue.
Rainfall trend and variability in semi-arid northern Namibia: Implications for smallholder agricultural production

Rainfall defines livelihood patterns among agrarian communities of the climate-change vulnerable semi-arid Sub-Saharan Africa. However, it remains inadequately studied, resulting in ineffective water management policies and weak agricultural growth in the region. Monthly rainfall data collected between 1987 and 2018 at four stations along a 1200 km climatic gradient in northern Namibia were analysed for annual, seasonal and monthly trends and variability. Descriptive measures and the Mann-Kendall test were used for rainfall characterisation and trend detection, respectively. Results showed an annually increasing rainfall trend, but with a downward trend in the dry season decreasing by -0.14 mm year–1 and an upward trend in the rainy season increasing by 7.74 mm year–1 across the study area. The rainy-season mean monthly rainfall showed predominantly increasing trends, while the dry-season ones exhibited insignificant decreasing trends. The study detected a decreasing rainfall gradient from the northeast towards the northwest with a range of 156.8 mm and concomitant increasing spatial-temporal variability. The upward rainfall trend has implications for rainy season floods, whereas the downward trend suggests dry season drought intensification in the area. These results could be useful for rainwater management planning in the study area and other dryland regions.
Increased population density depresses activity but does not influence emigration in the snail Pomatias elegans

Dispersal is a key trait linking ecological and evolutionary dynamics, allowing organisms to optimize fitness expectations in spatially and temporally heterogeneous environments. Some organisms can either actively disperse or reduce activity in response to challenging conditions, and both responses may be under a trade-off. To understand how such organisms respond to changes in environmental conditions, we studied emigration (the first step of dispersal) and activity behaviour in the gonochoric land snail Pomatias elegans, a litter decomposer that can reach very high local densities, over most of the range of ecologically relevant densities. We found that crowding had no detectable effect on emigration tendency in this species, contrary to previous results in many hermaphroditic snails. Pomatias elegans is nonetheless able to detect population density; we show they reduce activity rather than increase dispersal in response to crowding. We propose that limiting activity may be more advantageous than moving away in species with especially poor movement abilities, even by land mollusc standards, like P. elegans. Interestingly, emigration and activity were positively correlated independently of density; this dispersal syndrome may reflect an underlying pace-of-life syndrome, and is compatible with a dispersal-dormancy trade-off, which would require further investigation. Additionally, we found snails with heavier shells relative to their size tended to be less mobile, which may reflect physical and metabolic constraints on movement and/or survival during inactivity. We finally discuss how the absence of density-dependent dispersal may explain why P. elegans is often found at very high local densities, and the possible consequences of this behaviour for ecosystem functioning and litter decomposition.
Clinicopathological pattern of soft tissue sarcoma in a tertiary health institution in North Western Nigeria

Background: Soft tissue sarcomas are a rare group of heterogeneous tumours that consist of several neoplasia which differentiate into different cell lines. They could arise from the mesodermal or ectodermal embryonic germ layers. Rhabdomyosarcoma is the most common soft tissue tumour in the paediatric age group in most studies, while in adults, malignant fibrous histocytoma, liposarcoma and fibrosarcoma are seen to be more predominant. The study aims to highlight the histological patterns, clinical presentation, associated risk factors and the patients’ performance status at presentation. Methods: This is a 5-year retrospective between the period of 2010 to 2015 of all cancer patients diagnosed with soft tissue sarcoma, seen in the department of radiotherapy and oncology, a tertiary health centre in Sokoto Nigeria. Data collected included socio-demographic, histological type, clinical features, and performance status. Results: A total of 123 patients were reviewed during the study period of 2010 to 2015: males were 81 (65.9%) and females were 42 (34.1%), with a male to female ratio of 1.93:1. The commonest histological type in both the adult and paediatric age group was rhabdomyosarcoma. Most patients presented with a swelling as seen in 62 (50.4%) cases. The extremities were the commonest site of involvement, with the lower limbs consisting 41 (33%) of the total patients reviewed. Conclusions: Rhabdomyosarcoma was the most predominant histological type of soft tissue sarcoma seen over the review period and was seen in both the paediatric and adult age groups as the commonest type.
Profile and outcome of childhood tuberculosis treated with DOTS at a tertiary care hospital in central India: an observational study

Tuberculosis (TB) continues to be one of the most devastating and widespread infections in the world. World Health organization (WHO) has suggested a category based treatment of TB. Recently, Revised National Tuberculosis Control Programme (RNTCP), in association with Indian Academy of Pediatrics (IAP), has categorized various types of TB according to the existing WHO guidelines. Directly Observed Treatment Short (DOTS) course strategy aims at treatment of adult patients of tuberculosis to prevent them from disseminating the infection. Though children with tuberculosis do not contribute significantly in spread of infection in the community, but they suffer greatly from its morbidity and mortality. Hence it is important to include children as beneficiaries of the DOTS strategy.