Miracle-dz/UniFAR-FTUs huggingface dataset:
Homologous Protein Costimulation by Blockade of Inducible Costimulator-B7 Amelioration of Collagen-Induced Arthritis

B7 homologous protein (B7h)/B7-related protein 1 (B7RP-1) is a new member of the B7 family of costimulatory molecules that speciﬁcally interacts with inducible costimulator (ICOS) expressed on activated T cells. Collagen type II (CII)-induced arthritis (CIA) is an experimental model of arthritis that has been used to dissect the pathogenesis of human rheumatoid arthritis. In this study, we have investigated the effect of neutralizing anti-B7h mAb on the development and disease progression of CIA. Administration of anti-B7h mAb signiﬁcantly ameliorated the disease as assessed by clinical arthritis score and histology in the joints, and a beneﬁcial effect was also obtained by a delayed treatment after the onset of disease. Expression of ICOS and B7h was observed in the inﬂamed synovial tissue as well as in the draining lymph nodes (LNs) and expansion of ICOS (cid:1) T cells in the LN was reduced by the anti-B7h mAb treatment. Expression of mRNA for proinﬂammatory cytokines such as TNF- (cid:2) , IL-1 (cid:3) , and IL-6 in the joints was inhibited by the treatment. Proliferative responses and production of IFN- (cid:4) and IL-10 upon restimulation with CII in vitro were signiﬁcantly inhibited in LN cells from the anti-B7h mAb-treated mice. Serum anti-CII IgG1, IgG2a, and IgG2b levels were also reduced. Our present results showed a beneﬁcial effect of the B7h blockade on CIA through anti-inﬂammatory actions and inhibition of both Th1-
NONASYMPTOTIC CONVERGENCE ANALYSIS FOR THE UNADJUSTED LANGEVIN ALGORITHM1

In this paper, we study a method to sample from a target distribution π over Rd having a positive density with respect to the Lebesgue measure, known up to a normalisation factor. This method is based on the Euler discretization of the overdamped Langevin stochastic differential equation associated with π . For both constant and decreasing step sizes in the Euler discretization, we obtain nonasymptotic bounds for the convergence to the target distribution π in total variation distance. A particular attention is paid to the dependency on the dimension d, to demonstrate the applicability of this method in the high-dimensional setting. These bounds improve and extend the results of Dalalyan [J. R. Stat. Soc. Ser. B. Stat. Methodol. (2017) 79 651–676].
Evaluation of risk factors associated with nephropathy in type 2 diabetic patients in Rwanda

Background: Diabetic nephropathy is an emerging clinical and public problem and is related with poor outcomes such as heart failure, and end stage renal disease. In the Rwanda countryside there are no recent studies on renal complications. Objective: To evaluate risk factors associated with nephropathy in Type 2 diabetic patients in Rwanda. Methods: A case-control study was conducted from January to September 2019 in four hospitals of Republic of Rwanda. Diabetic patients were screened for nephropathy by measuring microalbuminuria. Those with microalbuminuria were the cases and those patients free of nephropathy were the controls. The study sample had 592 participants, 83 cases and 509 controls enrolled. Plasma glucose was measured by enzymatic colorimetric test. HbA1c test was performed using the unique procedure of Bio -Rad Variant II. Albuminuria was measured by quantitative method using spectrophotometer. Total plasma cholesterol, HDL cholesterol, LDL cholesterol, triglycerides, Urea and Creatinine were assayed by colorimetric methods using commercial kits. A questionnaire was used to assess other risk factors such as alcohol consumption, smoking, level of physical activity, family history of T2DM, obesity, stress, and demographic status. The data was analyzed on SPSS version 20. Statistical analysis was performed by Chi square to show association in nominal and ordinal data. Multivariate logistic regression analysis to select independent variables was performed. Odds ratio was used as measure of association. Results: In this study the prevalence of Diabetic nephropathy was 14%, (microalbuminuria was 12.5% and macroalbuminuria 1.5%). The major independent risk factors associated with diabetic nephropathy were male gender, long duration of type 2 diabetes (≥16 years), elevated HbA1c (> 7.5%) , poor adherence to diabetic medication, elevated creatinine (> 1.2 mg/dl), and lower level of education. Conclusion: Management of those modifiable risk factors of nephropathy could reduce its incidence in diabetic patients. Keywords— Type 2 Diabetes Mellitus, Nephropathy, Risk Factors, Rwanda.
DMSO_A_292991 139..152

Department of Neurology, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou 550001, People’s Republic of China Abstract: Diabetic peripheral neuropathy (DPN) is a common complication of diabetes mellitus (DM). The typical manifestation is a length-dependent “glove and sock” sensation. At present, diagnosis is mainly dependent on clinical manifestations. Since the pathogenesis is not clear, there are no effective treatment measures. Management consists mainly of glucose control, peripheral nerve nutrition, and other measures to delay the progress of the disease; early diagnosis is therefore crucial to improving prognosis and quality of life for patients with DPN. Due to the lack of obvious symptoms in 50% of patients and the low sensitivity of neuro-electrophysiology to small fibers, the missed diagnosis rate is high. Highresolution ultrasound (HRU), as a convenient noninvasive tool, has been proven by many studies to have excellent clinical value in diagnosing DPN. With the development of related new technology, HRU shows promise for the screening, diagnosing, and follow-up of DPN, which could serve as a biomarker and provide new diagnostic insights. In this paper, we review the ability of HRU to detect nerve cross-sectional area and blood flow, and echo and other image changes, and in showing the characteristics of peripheral nerve morphological changes in patients with DPN. We also explore the application of two other recent technological developments—shear wave elastography (SWE) and ultrasound scoring systems—in improving the diagnostic efficiency of HRU in peripheral neuropathy.
t eAcher s elf -e fficAcy of f uture P hysicAl e ducAtion t eAchers in c ontexts of i nclusion in Asic ducAtion 1

: This study investigated the level of teacher self-efficacy of future Physical Education teachers to the inclusion in Physical Education classes and its relation to the source of physiological and affective states, as well as the personal and contextual variables. The participants were 188 Physical Education undergraduate student teachers from two universities in the state of São Paulo, Brazil. The participants were between 18 and 38 years old (M = 22.6) and 51,6% were male. Data were collected through a questionnaire of characterization, self-efficacy scale for the inclusion of students with disability In Physical Education classes and, the sources of the teacher self-efficacy scale. The data, analyzed by means of descriptive statistics, revealed that the participants presented moderate levels of teacher self-efficacy for inclusion in Physical Education classes, being the inclusion of students with physical disability the dimension with the highest mean score. Physiological and affective states were related more powerfully to inclusion of students with intellectual disability than with physical and visual disability. Physiological and affective states were more strongly related to the inclusion of students with intellectual disabilities than to those with physical or visual disabilities. Given the relevance and regularity that inclusion has been present in Physical Education classes, it is essential that teacher education programs are able to offer opportunities for future teachers to acquire experiences that are fundamentally essential in building, strengthening and trusting their own competencies, in order to promote inclusion in regular school classes.
THE EFFECT OF THE PHYSICAL LEARNING ENVIRONMENT ON STUDENTS’ HEALTH, ENJOYMENT AND LEARNING 1Che

This study was conducted to analyze the suitability of the physical classroom learning environment and its effect on students’ health, enjoyment and learning. The participants of this study were 400 form four science students from six secondary schools in Johor, Malaysia. Students’ perception on physical aspects and its effect were measured using Physical Aspects Classroom Environment Inventory (PACE). The PACE consists of nine constructs. Six constructs which were furniture, facilities, space, lighting, indoor air quality and colour were used to measure the suitability of the physical classroom environment. While three constructs which were health, enjoyment, and learning were used to measure the effects of physical environment on students. The findings revealed that students perceived the suitability of physical environment is at high level for furniture, facilities, and lighting aspects, while moderate level for indoor air quality, space, and colour aspects. Results also showed that students perceived the physical environment have moderate effect on student’s health, enjoyment, and learning. Further analysis indicated that the physical environment have significant impact on students’ health, enjoyment and learning. These results provide valuable feedback to institutions and to educators in setting their learning environment
COMPARATIVE STUDY ON THE UTILIZATION OF RICE IN PREPARING GLUTEN FREE FOOD PRODUCTS

his study evaluated agronomic and yield characters, proximate and mineral composition, and functional properties of some rice varieties [Black Rice (BR), Egyptian Yasmine Rice (EYR) and Egyptian Hybrid Rice1(EHR1)]. Results showed that yield attributes characters were significantly varied among the three varieties. There were highly significant differences among the mean values of all cultivars under study regarding all agronomic and yield characters under study in the two seasons. Rice cultivars were significantly differed in all grain quality and cooking characters in the two seasons. Rice varieties have amylose content ranged from 18.06 to 21.48%. Results showed that BR has the highest protein content among the tested rice varieties (10.5%). From results, it is clear that EYR, EHR1 and BR could be considered as good sources of Fe, Mg and Zn in relative to the recommended daily dietary allowances (for children aged 6-59 months). Rice has good functional properties which enhance the nutritional quality of its products. Tortilla chips prepared from BR has the highest protein content (10.6%) while tortilla chips prepared from EHR1 has the lowest protein content (6.75%). In addition, EYR-tortilla chips have the highest overall acceptability score.
CEOR_A_234385 153..166

Stephanie F Armstrong Julian F Guest 1,2 1Catalyst Consultants, Rickmansworth, UK; 2Faculty of Life Sciences and Medicine, King’s College, London, UK Objective: To assess the health economic impact of cervical screening with liquid based cytology (LBC) compared with conventional cytology (CC) in Germany. Methods: An economic model was constructed depicting the management of a hypothetical cohort of women aged ≥20 years who undergo cervical screening in Germany. The model estimated the cost-effectiveness and cost-benefit of LBC compared with CC at 2017/18 prices over a time-horizon of 70 years. Results: Performing cervical screens with LBC instead of CC is expected to increase the probability of detecting a true positive over a subject’s lifetime by 73% (0.038 versus 0.022) and of diagnosing a subject with stage 3 cervical intraepithelial neoplasia (CIN3) (0.019 versus 0.011). Women screened with LBC instead of CC are expected to have a 57% reduction in the probability of having undetected CIN3 (0.006 versus 0.014) and to experience a 44% reduction in the probability of transitioning into disease progression (from 0.018 to 0.010). The mean discounted lifetime cost of healthcare resource use associated with performing cervical screens with LBC and CC was estimated at €4852 and €7523 per subject respectively. For every Euro invested in cervical screening with LBC instead of CC, the German healthcare system could potentially save ~€170 over a subject’s lifetime. Conclusion: Within the study’s limitations, the analysis showed that LBC affords a costeffective cervical screening test compared with CC in Germany, since it improves detection rates and has the potential to lead to a reduction in disease progression for less cost.
Human-induced traumas in the skulls excavated from Gokurakuji site, Kamakura, Japan

This study investigates the human-induced traumas in the skulls excavated from the Gokurakuji site macroscopically. Human-induced traumas were classified into four types, like gashes, incisions, scratches, and blunt force trauma. The results revealed that the number of skulls with gashes or incisions tended to be low (1 individual with a gash and 4 individuals with incisions out of 331 individuals) among those of previously reported populations in medieval and recent Japan. These results suggested that the skulls found on Gokurakuji site might be not have belonged to victims of the battle of Nitta Yoshisada in 1333. Additionally, the relatively high number of specimens with scratches (21 or 6.3%), also the second highest among the discussed sites, could have resulted from differences in diagnostic standards or differences in the purpose or method used for inducing scratches.
NSS_A_335462 1931..1941

1Ministry of Health, Manama, Bahrain; 2Department of Psychiatry, College of Medicine and Medical Sciences, Arabian Gulf University, Manama, Bahrain; 3Department of Clinical Pharmacy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia; 4Department of Mathematics and Statistics, Laboratory for Industrial and Applied Mathematics (LIAM), York University, Toronto, ON, Canada; 5Department of Nutrition, Faculty of Pharmacy and Medical Sciences, University of Petra, Amman, Jordan; 6Department of Medicine, College of Medicine, University Sleep Disorders Center, King Saud University, Riyadh, 11324, Saudi Arabia; 7The Strategic Technologies Program of the National Plan for Sciences and Technology and Innovation in the Kingdom of Saudi Arabia, Riyadh, Saudi Arabia; 8Psychiatry & Behavioral Sciences, Gerontology & Geriatric Medicine, and Biobehavioral Nursing, University of Washington, Seattle, WA, 98195-6560, USA Purpose: NOMOPHOBIA (NO MObile PHone PhoBIA) or problematic smartphone use is a psychological disorder in which people are afraid of being cut off from their mobile phones. Currently, there has been no direct assessment of mobile phone screen size in the home setting and its effect on nomophobia and related symptoms, such as insomnia. Thus, we investigated the association between nomophobia, insomnia, and mobile phone screen size in a young adult population in Bahrain. Patients and Methods: Using a descriptive, cross-sectional design, we surveyed participants aged 18 to 35 between August and September 2020 using an online questionnaire. Participants completed demographic questions and questions about personal mobile phones, the Nomophobia Questionnaire (NMP-Q), and the Insomnia Severity Index (ISI). The mobile phone screen size was determined using an open-source online database. Crude and adjusted regression analyses were fitted to examine the associations between the study variables. Results: A total of 549 individuals, 54% females, were included in the final analyses. One hundred and fourteen participants (21%) had severe nomophobia, and 81 (14%) had clinical insomnia. A strong positive pair-wise linear association was observed between NMP-Q and ISI β 0.15, P = 0.001. Age, sex, BMI, and mobile phone screen size showed no association with the NMP-Q. Conclusion: Nomophobia is very prevalent in young adult men and women, and it is closely associated with insomnia, regardless of mobile phone screen size, suggesting that mobile phone screen size should not be used as a proxy for hazardous usage.
Austin Virology and Retro Virology Identification of Pseudocowpox Virus in Angus Bull with Failure to Breed

Pseudocowpox, a Parapoxvirus, causes a common mild infection of the udder and teats of cows. Infection of genital organs has not been reported before in bulls. In this report, pseudocowpox virus (PCPV) was identified from one of two 1-year-old Angus bulls ( Bos taurus ) with red rashes and papule lesions on the surface of the penis. Inoculation of bovine turbinate cells or primary bovine testicular cells with the swab of the papule lesions produced CPE characteristic of pox virus infection. Parapoxvirus like particles were observed by EM in viral pellets of the tissue culture isolate. To confirm the virus, designated 14V10296 isolate, was a Parapoxvirus, viral DNA of the 14V10296 isolate was examined by PCR with pan Parapoxvirus primer sets that could amplify B2L gene of all four Parapoxviruses. The expected B2L amplicons of the 14V10296 isolate showed 99% homology to B2L of PCPV strain F00.120R. To further confirm the isolated virus is PCPV, PCR primers specific for Orf vascular endothelial growth factor gene and IL-10 and PCPV uracil DNA glycosidase (UDG) and IL-10, respectively, were used to amplify the viral DNA of the 14V10296 isolate. Only when PCR primers specific to PCPV UDG and IL-10 were used, expected products were amplified from viral DNA of the 14V10296 isolate, respectively. Phylogenetic analysis suggests the 14V10296 isolate is closely related to PCPV strain F00.120R, an isolate from reindeer. These results from tissue culture, EM, PCR amplification and DNA sequence analysis suggest that the bulls were infected by a PCPV which is closely related to PCPV strain F00.120R.
Low-Intensity Exercise Training Delays the Onset of Decompensated Heart Failure in the Spontaneously Hypertensive Heart Failur

Data regarding the effectiveness of chronic exercise training in improving survival in patients with congestive heart failure (CHF) is inconclusive. Therefore, we conducted a study to determine the effect of exercise training on survival in a welldefined animal model of heart failure, the lean male Spontaneously Hypertensive Heart Failure (SHHF) rat. In this model, animals typically present with decompensated, dilated heart failure (HF) between ~18-23 months of age. SHHF rats were assigned to sedentary (SED) or exercise trained (TR) groups at 9 and 16 mo. of age. Exercise training consisted of 6 months of low intensity treadmill running. Exercise training delayed the onset of overt heart failure and improved survival (p<0.01) independent of any effects on the hypertensive status of the rats. Training delayed the myosin heavy chain (MyHC) isoform shift from αto β-MyHC that was seen in sedentary animals that developed heart failure. Exercise was associated with a concurrent increase in cardiomyocyte length (≈ 6%), width, and area, and prevented the increase in length:width ratio seen in sedentary animals in heart failure. The increases in proteinuria, plasma atrial natriuretic peptide, and serum leptin levels observed in rats with heart failure were suppressed by low intensity exercise training. No significant alterations in sarco(endo)plasmic reticulum Ca ATPase, phospholamban, or Na/Ca exchanger protein expression were found in response to training. Our results indicate that 6 months of low intensity exercise training delays the onset of decompensated heart failure and improves survival in the male SHHF rat. Similarly, exercise intervention prevented or suppressed alterations in several key variables that normally occur with the Exercise Delays Heart Failure in SHHF Rat 3 development of overt CHF. These data are supportive of the idea that exercise may be a useful and inexpensive intervention in the treatment of heart failure.
A new modeling technique based on performance data for photovoltaic modules and horizontal axis wind turbines

This article proposes new methods of modeling and simulation of photovoltaic and horizontal wind turbine systems. The photovoltaic and horizontal wind turbines are modeled by the use of actual data sheets listed in the lookup table model. Moreover, artificial neural network numerical technique is used to simulate and evaluate the designed systems. The implemented work may help the designer and investor to elect a specified photovoltaic module and/or the horizontal wind turbine according to the demanded power load, thence predicting the operating conditions before the establishment process. The results show good matching with the actual data for the photovoltaic and horizontal wind turbine systems.
Comparing the Efficacy of Gefitinib, Erlotinib, and Afatinib in Non-Small Cell Lung Cancer with Activating Epidermal Growth Factor Receptor ( EGFR ) Mutations

Gefitinib and erlotinib are reversible Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors (EGFR-TKIs). Compared to standard chemotherapy, both of these agents have demonstrated significantly higher response rates and are associated with prolonged survival in patients with advanced Non-Small Cell Lung Cancer (NSCLC) harboring an activating EGFR mutation such as an axon 19 deletion or an L858R mutation. These agents are recommended as first-line treatments for NSCLCs with such mutations. Afatinib belongs to a class of irreversible inhibitors of the human epidermal receptor family. Two recent large-scale randomized trials demonstrated the high efficacy of afatinib as a first-line treatment for NSCLC with activating mutations of EGFR compared to standard chemotherapy. Currently, various EGFR-TKIs including gefitinib, erlotinib, and afatinib are offered as first-line treatments in patients with advanced NSCLC harboring activating EGFR mutations. However, it is not clear if any of this EGFR-TKI should a first-line therapy advantage in these patients over the others. Herein, the latest data involving the use of these agents is reviewed. as an exon 19 deletion or an L858R mutation [1,2]. Several randomized phase III trials of gefitinib and erlotinib as first-line treatments in patients with NSCLC with the aforementioned types of mutations demonstrated significantly longer Progression-Free Survival (PFS) times, higher degrees of tumor shrinkage, better tolerability, and an extended quality of life compared to platinum doublet chemotherapy [3-6]. Based on these studies, gefitinib and erlotinib are recommended as first-line treatment agents for these types of malignancies. Afatinib is an irreversible pan Human Epidermal Receptor (pan-HER) inhibitor that down regulates ErbB signaling by covalently binding to the kinase domain of EGFR, HER2, or HER4. Large scale randomized phase III trials that compared afatinib to standard platinum-based chemotherapy as first-line therapy demonstrated
University of Birmingham Polymers from macrolactones

Recent advances in the ring-opening polymerization (ROP) of macrolactones (MLs) have afforded access to novel, potentially degradable polymeric materials featuring long aliphatic chains. These developments extend the synthetic robustness and versatility of ROP to a greater range of interesting monomers, many of which can be derived from sustainable or renewable AC CE PT ED M AN US CR IP T
Structure-Activity of Sulfones and Sulfonamides

The molecular interaction of various sulfones and sulfonamides with partially purified dihydropteroate synthetase from Neisseria meningitidis M-166 has been examined. The mode of action of the sulfones was similar to that of the sulfonamides. Both groups of drugs were competitive inhibitors of dihydropteroate synthetase with respect to p-aminobenzoate in a partially purified enzyme preparation. 4,4'-Diaminodiphenylsulfone was three times more effective than sulfadiazine and nine times more effective than sulfanilamide as a competitive inhibitor of dihydropteroate synthetase. The inhibitory activity of 4-amino-4'-acetamidodiphenylsulfone and 4-amino-4'-formamidodiphenylsulfone in this system eliminated their prior conversion to 4,4'-diaminodiphenylsulfone as a requirement for activity.