Miracle-dz/UniFAR-FTUs huggingface dataset:
p=constant compression on loose Hostun sand: The case of an anisotropic response

Experimental data from axially symmetric compression test at constant mean pressure p on Hostun sand from Flavigny experiments on loose sands are used to study the validity of an "isotropic" modelling at different densities . It is found that the material response is not isotropic even at small deviatoric stress. As an "isotropic" behaviour is found for compression test at constant volume on the same sand, this new result questions the unicity of the trajectory in the classical phase space of soil mechanics (q,p,v), with q being thed deviatoric stress, v the specific volume. This asks whether the space shall be taken larger than 3d or not. Pacs # : 5.40 ; 45.70 ; 62.20 ; 83.70. Fn
(2015). Neural circuitry for rat recognition memory. Behavioural Brain (SI),

• We present a summary of ﬁndings from object recognition memory tasks revealing the roles played by cortical, hippocampal and thalamic regions. • We report a neural circuit for object–location association recognition memory and temporal order recognition memory. • The neural circuit involves the perirhinal cortex, medial prefrontal cortex and hippocampus. • Experimental evidence shows that all structures in the circuit play critical roles in memory formation which can potentially be differentiated. Information concerning the roles of different brain regions in recognition memory processes is reviewed. The review concentrates on ﬁndings from spontaneous recognition memory tasks performed by rats, including memory for single objects, locations, object–location associations and temporal order. Partic- ular emphasis is given to the potential roles of different regions in the circuit of interacting structures involving the perirhinal cortex, hippocampus, medial prefrontal cortex and medial dorsal thalamus in recognition memory for the association of objects and places. It is concluded that while all structures in this circuit play roles critical to such memory, these roles can potentially be differentiated and differ- ences in the underlying synaptic and biochemical processes involved in each region are beginning to be uncovered. ©
OPTH_A_294427 2421..2435

Clinical Development and Medical Affairs, Alcon Research, LLC, Johns Creek, GA, USA Abstract: Dry eye disease (DED) is a multifactorial ocular condition characterized by a loss of homeostasis of the tear film resulting in ocular symptoms of discomfort, irritation, and visual disturbance, all of which significantly impact the patients’ social and occupational quality of life. While management of DED depends on the severity of symptoms and signs, use of artificial tear products (ATPs) that replace or supplement the deficient natural tear film is the mainstay treatment option. In this review, we present a decade of evidence on Systane Ultra (polyethylene glycol [PEG]/propylene glycol [PG] with hydroxypropyl guar [HP guar]) in effectively managing DED. The active demulcents in Systane Ultra—PEG, PG, along with HP guar gelling technology—provide optimal ocular surface protection and lubrication to heal damaged areas of the cornea caused by DED and, therefore, are recommended for patients with both aqueous and/or mucin layer deficiencies. Over the years, several clinical studies have shown that PEG/PG with HP guar provides long-lasting relief from dry eye and has often been chosen as a standard or comparator against other ATPs. Here, we describe the salient features of PEG/PG with HP guar—its constituents and their mechanisms of action. Furthermore, we summarize results from a systematic literature search that identified 23 relevant publications further emphasizing on the effectiveness and safety of PEG/PG with HP guar in alleviating the signs and symptoms of DED.
Metabolically Healthy Obese (MHO) in Adults and Adolescents: Where We Are

A unique subset of obese individuals who appear to be protected from the development of metabolic disturbances has been identified in clinical practice and is termed metabolically healthy but obese (MHO). The true prevalence of the MHO phenotype varies widely from approximately 6% to75% of obese adults and from 6–36% in obese adolescents. Currently, there are no clear accepted criteria on the definition of MHO. The strong effect of pubertal status on metabolic health cannot be excluded in obese adolescents. To clarify this definition we need the collaboration of the scientific community. Numerous possible mechanisms underlying MHO have been suggested, including adipose tissue distribution and inflammation. The current evidence cannot confirm that MHO subjects are permanently protected from the risk of obesity-associated metabolic complications. This transition might be minimized by appropriate lifestyle habits. No standard practice guidelines for the prevention and treatment of MHO can be proposed to clinicians. A decent attitude would be to regularly monitor CVD risk factors in obese adult and adolescent MHO patients especially elevated triglycerides, glycaemia, HOMA and C-reactive protein as well as low HDL-C. A special surveillance should be applied to prevent any increase in waist circumference (WC) as the MHO phenotype may be maintained by promoting lower WC and by the prevention of any further weight gain. Identifying obese patients with this protective profile could help the medical community determine which part of the obese patients need to be only periodically observed and which need to have early therapeutic interventions
Optimized geometries for future generation optical lattice clocks

Atoms deeply trapped in magic wavelength optical lattices provide a Doppler- and collision-free dense ensemble of quantum emitters ideal for high-precision spectroscopy and they are the basis of some of the best optical atomic clocks to date. However, despite their minute optical dipole moments the inherent long-range dipole-dipole interactions in such lattices still generate line shifts, dephasing and modified decay. We show that in a perfectly filled lattice line shifts and decay are resonantly enhanced depending on the lattice constant and geometry. Potentially, this yields clock shifts of many atomic linewidths and reduces the measurement by optimizing the lattice geometry. Such collective effects can be tailored to yield zero effective shifts and prolong dipole lifetimes beyond the single-atom decay. In particular, we identify dense 2D hexagonal or square lattices as the most promising configurations for an accuracy and precision well below the independent ensemble limit. This geometry should also be an ideal basis for related applications such as superradiant lasers, precision magnetometry or long-lived quantum memories.
Preparation and techno-economic feasibility of whey based watermelon beverage using betel leaves distillate

In the present study, efforts have been made to develop whey based watermelon beverage with the addition of betel leaves distillate viz . , 0 – 3%. Storage study was undertaken for a period of 30 days at 7±1 0 C at the regular interval of 10 days. The prepared beverage was evaluated using 9 point Hedonic scale for overall acceptability. Techno-economic feasibility of beverage on small scale (250 liter/day) was worked out. The study revealed that the beverage prepared with the addition of 2% betel leaves distillate scored high i.e. 8.5 on 9-point Hedonic scale. It was prepared from watermelon juice containing 14.20% TSS, 8% total sugar, 0.15% acidity, 1.0% ascorbic acid and pH 5.1. Chhana whey used for beverage preparation contained 6.30% Total Solid, 0.24% acidity, pH 4.6, 4.80% Lactose, 0.10% Protein and 0.10% Fat. The fresh beverage (2% betel leaves distillate) contained 21.13% TSS, 0.16% acidity, pH 5.1, 0.78 mg/100 gm ascorbic acid, 2.92% reducing sugar and 16.29% total sugar. After 30 days interval slight variation in various parameter have been observed i.e. 21.66%TSS, 0.163% acidity, pH 5.05, 0.76 mg/100 gm ascorbic acid, 3.82% reducing sugar and 16.11% total sugar having average sensory score 8.4. It was observed that betel leaves distillate worked as a natural preservative. Techno-economic feasibility analysis suggested that beverage prepared from 2% betel leaves distillate was costing Rs 6.12/250 ml which is much lower than other similar type of drinks.
UNIVERSITY OF CALIFORNIA, MERCED THE EFFECTS OF RACIAL AND CLASS NEIGHBORHOOD COMPOSITION ON COMMUNITY GARDEN OUTCOMES A Thesis submitted in partial satisfaction of the requirements for the degree of Master of Arts

Low-income communities and communities of color often lack access to fresh food from large food retailers within the traditional food system. Growing public concern for these and other food inequalities across the U.S. has generated interest in alternate food outlets such as community gardens as solutions. However, recent scholarly work suggests that community gardens may be more prevalent in predominately white or higher-income communities. This research further suggests that the primary goals and ideology that drive the development of community gardens may resonate more with white higher-income participants than lower-income or racial minorities. As a result, the participants in these programs are often primarily white, high-income individuals. By using negative binomial and spatial regression techniques to examine data from New York City and Minnesota, the current research project aims to clarify to what degree communities of color and low-income communities face a lack of access to community gardens. Further, this research investigates variation in the ideology or framing associated with community gardens with different demographic profiles. Findings suggest lowincome communities and communities of color do not lack access to community gardens at a higher rate than white and high-income communities. However, findings show that the goals and ideology of community gardens vary across communities with different demographics. This research develops a more nuanced understanding of the race and class-based barriers to participating in community gardens. It adds to the literature on food access by revealing the degree to which community gardens as alternative, local food programs are accessible and welcoming to low-income, black, and Latino individuals, who have historically experienced barriers to accessing healthy food. Findings suggest that more work could be done to ensure accessibility to community gardens in less educated communities, and that gardens in more diverse communities could focus more on the benefits valued by black Americans and Latinos to ensure these groups feel welcome in the gardens.
Institutional Knowledge at Singapore Management University How do institutional investors trade

Using a novel, and detailed custody trades dataset, this paper analyzes the trading behavior of institutions. Extant studies have examined the effects of past performance on trading by retail investors, day traders, and futures floor traders. Yet very little work has been done on institutions. We find that unlike other investors, institutions take on more risk following an increase in net profit and loss. However, the responses to a gain and loss are highly asymmetric. Institutions aggressively reduce risk in the wake of losses, but only mildly increase risk in the wake of gains. This asymmetry is more pronounced for experienced and older funds. Further, the performance dependence varies over the calendar year, and manifests itself at the security but not at the portfolio level. We relate these findings to the behavioral theories of narrow framing, dynamic loss aversion, and overconfidence. Abstract Using a novel, and detailed custody trades dataset, this paper analyzes the trading behavior of institutions. Extant studies have examined the effects of past performance on trading by retail investors, day traders, and futures floor traders. Yet very little work has been done on institutions. We find that unlike other investors, institutions take on more risk following an increase in net profit and loss. However, the responses to a gain and loss are highly asymmetric. Institutions aggressively reduce risk in the wake of losses, but only mildly increase risk in the wake of gains. This asymmetry is more pronounced for experienced and older funds. Further, the performance dependence varies over the calendar year, and manifests itself at the security but not at the portfolio level. We relate these findings to the behavioral theories of narrow framing, dynamic loss aversion, and overconfidence.
Effect of tillage practices on productivity of wheat ( Triticum aestivum L.)

A field experiment was conducted at the research farm of ICAR-Indian Agricultural research Institute, New Delhi during the rabi season 2014-15 to study the effects of various tillage practices on biophysical parameters, yield attributes and yield of wheat in pigeonpea-wheat cropping system. The experiment was conducted in a randomized block design (RBD) replicated thrice. The following treatments were included such as zero tilled permanent narrow bed (PNB), zero tilled permanent narrow bed plus residue (PNB+R), zero tilled permanent broad bed (PBB), zero tilled permanent broad bed plus residue (PBB+R), zero tilled flatbed (ZT), zero tilled flatbed plus residue (ZT+R). The yield attributes viz . plant height, plant biomass, leaf area index (LAI) etc. were significantly influenced with tillage practices. Yield was recorded significantly higher under PBB+R followed by ZT+R, ZT, PBB, PNB+R, PNB and CT.
ANAESTHETIC TECHNIQUES FOR ORTHOPAEDIC SURGERIES IN BENUE STATE

Background: Orthopaedic surgery entails operating on osseous and non-osseous structures of the limbs, spine and joints of the body. Like all other surgeries, orthopaedic surgeries require the administration of anaesthesia to patients. Central neuraxial blocks for lower limb surgeries has gained worldwide acceptance because it has lower mortality rates, shorter hospital stay, reduced patient cost and decreased in-hospital complications. General anaesthesia (GA) and regional anaesthesia (RA) have been used successfully for upper extremity orthopaedic procedures. It is also the technique of choice in the paediatric age group, the critically ill patients as well as being use for upper limb surgeries. This study was undertaken to ascertain the anaesthetic techniques employed in orthopaedic surgeries in the Benue State University Hospital, Makurdi. Methodology: A total of 117 case files of eligible patients were retrieved from the records department. Relevant information were extracted from the patients’ folders and transferred into a prepared proforma. Data collected were analyzed using SPSS version 25 using simple statistics. Results: A total of 117 orthopaedic surgical cases were evaluated. The age bracket with the most number is that between 21 t0 30 years with 28 making up 23.9% of the study population. Eighty-five patients were male, accounting for 72.6% of the study population, while 32 were female, making up the remaining 27.4%. Most of the patients were between ASA II and ASA III with 47 (40.2%) and 45 (27.4%). A total of 131preoperative diagnosis were made either singly or in combination with the two most common indications for surgery being femoral fracture and tibial fracture with 23 and 20 accounting for 17.3% and 15.0% of the variables. Of the total of 125 surgical procedures that were undertaken in this study, open reduction and internal fixation (ORIF) were carried the most, recording 35 accounting for 28.0% of the variables. Similarly, of the total of 117 anaesthetic procedures that were undertaken, sub-arachnoid block (SAB) was employed 65 times accounting for 55.6% of the variables. Also, of the 13 episodes of complications that were recorded, hypotension
Intravital Imaging The Harvard community has made this article openly available. Please share how this access benefits you. Your story matters

Until recently, the idea of observing life deep within the tissues of a living mouse, at a resolution sufficient to pick out cellular behaviors and molecular signals underlying them, remained a much-coveted dream. Now, a new era of intravital fluorescence microscopy has dawned. In this Primer, we review the technologies that made this revolution possible, and demonstrate how intravital imaging is beginning to provide quantitative and dynamic insights into cell biology, immunology, tumor biology and neurobiology.
Structure-property relationships in metal-organic frameworks for hydrogen storage. Colloids and Surfaces A. Physicochemical and ,

Experimental hydrogen isotherms on several metal-organic frameworks (IRMOF-1, IRMOF-3, IRMOF-9, ZIF-7, ZIF-8, ZIF-9, ZIF-11, ZIF-12, ZIF-CoNIm, MIL-101 (Cr), NH 2 -MIL-101 (Cr), NH 2 -MIL-101 (Al), UiO-66, UiO-67 and HKUST-1) synthesized in-house and measured at 77 K and pressures up to 18 MPa are presented, along with N 2 adsorption characterization. The experimental isotherms together with literature high pressure hydrogen data were analysed in order to search for relationships between structural properties of the materials and their hydrogen uptakes. The total hydrogen capacity of the materials was calculated from the excess adsorption assuming a constant density for the adsorbed hydrogen. The surface area, pore volumes and pore sizes of the materials were related to their maximum hydrogen excess and total hydrogen capacities. Results also show that ZIF-7 and ZIF-9 (SOD topology) have unusual hydrogen isotherm shapes at relatively low pressures, which is indicative of “breathing”, a phase transition in which the pore space increases due to adsorption. This work presents novel correlations using the modelled total hydrogen capacities of several MOFs. and volume capacities of on-board storage systems. Such design tools will allow hydrogen to be used as an energy vector for sustainable mobile applications such as transport, or for providing supplementary power to the grid in times of high demand.
Ionic Liquids in Multiphase Systems Ionic Liquids in Multiphase Systems

Ionic liquids (ILs) can be used to replace one or more phases in conventional oil/water emulsions including Pickering emulsions—surfactant-free emulsions which utilize nano-or micron-sized particles to stabilize the immiscible liquid-liquid interface. Due to the extreme tunability of both the ILs and particles used, the study of IL-based Pickering emulsions yields novel emulsion morphologies and insights into the ionic liquid-liq- uid-particle interactions present. This work discusses extensive experimental work on IL-based Pickering emulsions and IL/liquid interfaces, emphasizing unique phenom- ena—such as “bridging” between emulsion droplets and spontaneous particle transport across the interface—never observed in more conventional Pickering emulsions. Molecular dynamics (MD) simulations of particles at the IL/liquid interface are also discussed, and fundamental insights from these simulations are used to enhance under- standing of the unique interface behavior revealed by experiment.
Effects of different dietary copper sources on laying hen performance and egg yolk cholesterol 1 , 2 , 3

An experiment was conducted using a total of 120 Lohmann Brown hens, 16 wk of age, to compare 3 different supplemental dietary Cu sources incorporating supraoptimal amounts of Cu (250 mg/kg) on layer performance, egg yolk cholesterol, and blood parameters. Layers were randomly allocated to 4 dietary treatments with 10 replications of 3 birds each for each treatment. Layers were fed diets containing 0 (control) or 250 ppm of Cu from Cu sulfate, Cu proteinate, or Cu lysine for 24 wk. No differences were observed among Cu sources for BW, egg mass, feed conversion, egg specific gravity, egg yolk cholesterol, plasma total cholesterol, high-density lipoprotein cholesterol, triglycerides, or glutathione peroxidase. Supplementation with 250 ppm of Cu sulfate improved egg production but decreased egg weight ( P < 0.05) and feed intake ( P < 0.01) as compared with the other diets. Supplementation with Cu proteinate resulted in decreased feed intake ( P < 0.01), but egg production, egg mass, and egg weight were not changed as compared with the controls. Eggshell thicknesses of layers fed the Cu sulfate and Cu lysine diets were lower than the eggshell thickness of layers fed the control diet ( P < 0.001). Copper contents of eggs and excreta were significantly ( P < 0.001) increased regardless of Cu source as compared with birds fed the control diet. The results of this trial did not con-firm the finding that Cu alters lipid metabolism and decreases cholesterol in the egg yolk. We conclude that increasing the dietary Cu intake through the use of different Cu compounds did not affect layer performance and cholesterol content of the egg yolk.
Enhanced inhibition of nasal epithelial cell repair by innate stimulation in patients with allergic rhinitis

Introduction. Impaired repair of airway epithelium may lead to per- sistence of inflammation and remodelling. Regeneration of injured epithelium is a complex phenomenon and the role of toll-like receptors (TLRs) and respiratory virus products in this process have not been es-tablished. Aim of the study. In this study we aimed to test if wound repair in nasal epithelial cells is modulated by microbial products and if this process was different in patients with allergic rhinitis and in healthy subjects. Materials and methods. Injured human nasal epithelial cells (hNECs) monolayers were incubated with the toll-like receptors agonists: poly (I:C) and lipopolisacharide (LPS); allergen Der p1, and supernatants from virus-infected epithelial cells. Regeneration of injured epithelium was assessed by measuring changes in the area of epithelial damage. Results. Addition of either poly (I:C) or LPS induced a dose depen- dant inhibition of wound repair in hNECs monolayers. Supernatants from RV1b-infected cells decreased epithelial cell regeneration after mechanical injury only in allergic patients. At baseline conditions the dynamics of epithelial repair was similar in allergic and non-allergic epithelium. However, inhibitory effects of innate stimuli on epithelial repair was stronger in patients with allergic rhinitis as compared to healthy individuals. Conclusions. This study showed that microbial products may affect regeneration of the nasal epithelium, and allergic patients are more susceptible to suppression of epithelial regeneration. gen and fibronectin and cultured with hormonally supple-mented BEGM at 37 °C with 5% CO2. Fresh medium was replaced every 48h until a monolayer formed. For the first two medium replacements, BEGM containing 1% of serum substitute (Ultroser G; Cytogen, Lodz, Poland) was used. Confluent cultures were trypsynized with 0,1% trypsin-ED-TA solution (Sigma-Aldrich) and cells were splited into un-coated 35-mm-diameter Petri dishes with 2-mm square grids on the bottom surfaces (Invitrogen, Life Technolo-gies, CA USA) for further experiments. The epithelial nature of cultured cells was confirmed by intracellular staining for anti-cytokeratin 19, assessed by cytofluorometry using a BD LSR Fortessa Analyzer (Becton Dickinson,Warsaw, Po-land).