Miracle-dz/UniFAR-FTUs huggingface dataset:
Large‐scale asymptotics of velocity‐jump processes and nonlocal Hamilton–Jacobi equations

We investigate a simple velocity jump process in the regime of large deviation asymptotics. New velocities are taken randomly at a constant, large, rate from a Gaussian distribution with vanishing variance. The Kolmogorov forward equation associated with this process is the linear BGK kinetic transport equation. We derive a new type of Hamilton–Jacobi equation which is nonlocal with respect to the velocity variable. We introduce a suitable notion of viscosity solution, and we prove well‐posedness in the viscosity sense. We also prove convergence of the logarithmic transformation toward this limit problem. Furthermore, we identify the variational formulation of the solution by means of an action functional supported on piecewise linear curves. As an application of this theory, we compute the exact rate of acceleration in a kinetic version of the celebrated F–KPP equation in the one‐dimensional case.
Semantic Categories of Reporting Verbs across Four Disciplines in Research Articles

This paper investigates semantic categories of reporting verbs across four disciplines: Accounting, Applied Linguistics, Engineering and Medicine in research article genre. A general corpus of one million words and sub-corpus (for each discipline) were compiled from a total of 120 articles representing 30 articles from each discipline. In this study, two levels of analysis were conducted. Firstly, I randomly selected five articles from each discipline and read and reread each article identifying what reporting verbs are used, in what context are used and why such reporting verbs are used. This process enabled me to identify semantic categories of reporting verbs. Secondly, on the basis of the identified list of semantic categories of reporting verbs, I used the list in generating concordance output for quantitative textual analysis of each sub-corpus of the four disciplines, as well as the general corpus. The results of the study show that writers from both Accounting and Applied Linguistics are having a high frequency of reporting verbs than writers from Engineering and Medicine disciplines. It also shows that there are certain commonalities and differences between the disciplines. For example, all the disciplines are having frequency of the three semantic categories of reporting verbs but with certain degree of variations. The study recommends raising awareness of students on semantic categories of reporting verbs. The results could also help EAP/ESP teachers in designing course materials for discipline specific reporting verbs. It could also be helpful for textbook course designers in developing textbooks for teaching reporting verbs.
Dynamic Time Lag Regression: Predicting What & When

This paper tackles a new regression problem, called Dynamic Time-Lag Regression (DTLR), where a cause signal drives an effect signal with an unknown time delay. The motivating application, pertaining to space weather modelling, aims to predict the near-Earth solar wind speed based on estimates of the Sun's coronal magnetic field. DTLR differs from mainstream regression and from sequence-to-sequence learning in two respects: firstly, no ground truth (e.g., pairs of associated sub-sequences) is available; secondly, the cause signal contains much information irrelevant to the effect signal (the solar magnetic field governs the solar wind propagation in the heliosphere, of which the Earth's magnetosphere is but a minuscule region). A Bayesian approach is presented to tackle the specifics of the DTLR problem, with theoretical justifications based on linear stability analysis. A proof of concept on synthetic problems is presented. Finally, the empirical results on the solar wind modelling task improve on the state of the art in solar wind forecasting.
Food Tourists’ Intentions Within The TPB Framework (M00, M31)

Behavioural Intention According to the Theory of Planned Behaviour (TPB), attitudes toward behaviour (AtB), subjective norms (SN) and perceived behavioural control (PBC) affect intentions (BI). The purpose of this paper is to examine food tourists’ intentions using TPB. A convenience sampling survey method was used to collect data. A social networking group of gourmets in Turkey were selected for the sampling frame and 137 usable surveys were obtained. A hierarchical regression analysis was used to test the model. The results showed that food tourists’ intentions can be predicted simply through AtB and SN (adjusted R 2 =0.29). PBC did not reveal any effect on intentions. Behavioural and normative beliefs were also significant. Research model was converted to the Theory of Reasoned Action (TRA).
Measuring the creation and adoption of new technologies using trade and patent data

Emerging technologies are thought to be shaping the new industrial landscape, potentially creating opportunities for developing countries to industrialise through increased productivity, but also the risk that they may be excluded from the benefits of these technologies through reshoring and by eroding the competitive advantage of developing countries. In this paper we look to identify trade (i.e. imports and exports) and inventions (patents) in 4IR technologies, as a means of identifying the development, production and use of such technologies globally. The paper provides information on those countries which are leading the technology race, those which are not leading but still following, and those which are being left behind. To achieve this, the paper uses detailed patent data to identify the technology leaders in the fourth industrial revolution, and trade data to identify the producers and users of these technologies. The paper subsequently relates the use of these technologies to indicators of the level of industrial development.
The Effects of Export Diversification on Economic Growth in Cameroon

This study is designed to investigate into the nature of export diversification and the relationships between export diversification and economic growth in Cameroon. Using data from 1980-2012, the Vector Autoregressive (VAR) technique of estimation is adopted to stimulate policies necessitated by the study. In reality the study establishes that export diversification had positively and significantly affected economic growth in Cameroon within the period of study. This finding is ironical since the economy of Cameroon has timidly grown over the years. Based on the VAR results, we further recommend the expansion of the export base by acquiring new production techniques, research on new products, marketing and the provision of incentives and subsidies for private sector development. Redesigning of education curriculum to train qualified man power in the export sector of the economy. Furthermore the government should properly manage the public debt and especially the external debt and the consistent negative balance of payments position which sucks away the benefits of external trade from Cameroon.
Treatment of an infected patellofemoral arthroplasty using an articulating cement spacer

H istorically, patellofemoral arthroplasty has been limited because of high failure rates associated with early implant designs. Increased understanding of patellofemoral mechanics and improvements in implant design have revived its use. Recent literature has shown patellofemoral arthroplasty to be an effective interim treatment option for patients with isolated patellofemoral osteoarthritis. As with all prosthetic devices in orthopaedics, infection represents one of the most concerning postoperative complications in patellofemoral arthroplasty. In the treatment of infected total knee arthroplasty, two-stage reimplantation with an articulating antibiotic spacer has been shown to effectively treat infection while preserving motion in the joint. Similarly, we present the previously undescribed use of an articulating antibiotic spacer in the treatment of an infected patellofemoral arthroplasty. Informed consent was obtained from the patient.
How the thermal environment shapes the structure of termite mounds

A computational model has been developed to predict the role of environment in the forms and functions of termite mounds. The proposed model considers the most relevant forces involved in the heat transfer process of termite mounds, while also reflecting their gas-exchange function. The method adopts a system configuration procedure to determine thermally optimized mound structures. The model successfully predicts the main architectural characteristics of typical Macrotermes michaelseni mounds for the environmental conditions they live in. The results indicate that the mound superstructure and internal condition strongly depend on the combined effect of environmental forces. It is noted that mounds being exposed to higher solar irradiances develop intricate lateral channels, inside, and taller and more pronounced spire tilt towards the Sun, outside. It is also found that the mounds' spire tilt angle depends on the geographical location, following the local average solar zenith angle for strong irradiances. Although wind does not influence the overall over-ground mound shape, it significantly affects the mound internal condition. The results of this study resonate with what is seen in nature. The proposed approach provides a broader view of the factors that are effective in the form and function of a naturally made structure.
Antioxidant supplementation slows telomere shortening in free-living white stork chicks

Telomere length (TL) and shortening is increasingly shown to predict variation in survival and lifespan, raising the question of what causes variation in these traits. Oxidative stress is well known to accelerate telomere attrition in vitro, but its importance in vivo is largely hypothetical. We tested this hypothesis experimentally by supplementing white stork (Ciconia ciconia) chicks with antioxidants. Individuals received either a control treatment, or a supply of tocopherol (vitamin E) and selenium, which both have antioxidant properties. The antioxidant treatment increased the concentration of tocopherol for up to two weeks after treatment but did not affect growth. Using the telomere restriction fragment technique, we evaluated erythrocyte TL and its dynamics. Telomeres shortened significantly over the 21 days between the baseline and final sample, independent of sex, mass, size and hatching order. The antioxidant treatment significantly mitigated shortening rate of average TL (−31% in shorter telomeres; percentiles 10th, 20th and 30th). Thus, our results support the hypothesis that oxidative stress shortens telomeres in vivo.
ALOX5, LPA, MMP9 and TPO gene polymorphisms increase atherothrombosis susceptibility in middle-aged Mexicans

Atherothrombosis is the cornerstone of cardiovascular diseases and the primary cause of death worldwide. Genetic contribution to disturbances in lipid metabolism, coagulation, inflammation and oxidative stress increase the susceptibility to its development and progression. Given its multifactorial nature, the multiloci studies have been proposed as potential predictors of susceptibility. A cross-sectional study was conducted to explore the contribution of nine genes involved in oxidative stress, inflammatory and thrombotic processes in 204 subjects with atherothrombosis matched by age and gender with a healthy group (n = 204). To evaluate the possibility of spurious associations owing to the Mexican population genetic heterogeneity as well as its ancestral origins, 300 unrelated mestizo individuals and 329 Native Americans were also included. ALOX5, LPA, MMP9 and TPO gene polymorphisms, as well as their multiallelic combinations, were twice to four times more frequent in those individuals with clinical manifestations of atherothrombosis than in the healthy group. Once adjusting for population stratification was done, these differences remained. Our results add further evidence on the contribution of ALOX5, LPA, MMP9 and TPO polymorphisms to atherothrombosis development in the middle-aged group, emphasizing the multiethnic studies in search of gene risk polymorphisms.
Characterizing reservoirs of infection and the maintenance of pathogens in ecosystems

We use a previously published compartmental model of the dynamics of pathogens in ecosystems to define and explore the concepts of maintenance host, maintenance community and reservoir of infection in a full ecological context of interacting host and non-host species. We show that, contrary to their current use in the literature, these concepts can only be characterized relative to the ecosystem in which the host species are embedded, and are not ‘life-history traits’ of (groups of) species. We give a number of examples to demonstrate that the same (group of) host species can lose or gain maintenance or reservoir capability as a result of a changing ecosystem context, even when these changes primarily affect non-hosts. One therefore has to be careful in designating host species as either maintenance or reservoir in absolute terms.
Prediction of polyproline II secondary structure propensity in proteins

Background: The polyproline II helix (PPIIH) is an extended protein left-handed secondary structure that usually but not necessarily involves prolines. Short PPIIHs are frequently, but not exclusively, found in disordered protein regions, where they may interact with peptide-binding domains. However, no readily usable software is available to predict this state. Results: We developed PPIIPRED to predict polyproline II helix secondary structure from protein sequences, using bidirectional recurrent neural networks trained on known three-dimensional structures with dihedral angle filtering. The performance of the method was evaluated in an external validation set. In addition to proline, PPIIPRED favours amino acids whose side chains extend from the backbone (Leu, Met, Lys, Arg, Glu, Gln), as well as Ala and Val. Utility for individual residue predictions is restricted by the rarity of the PPIIH feature compared to structurally common features. Conclusion: The software, available at http://bioware.ucd. ie/PPIIPRED, is useful in large-scale studies, such as evolutionary analyses of PPIIH, or computationally reducing large datasets of candidate binding peptides for further experimental validation.
A practical view of fine-mapping and gene prioritization in the post-genome-wide association era

Over the past 15 years, genome-wide association studies (GWASs) have enabled the systematic identification of genetic loci associated with traits and diseases. However, due to resolution issues and methodological limitations, the true causal variants and genes associated with traits remain difficult to identify. In this post-GWAS era, many biological and computational fine-mapping approaches now aim to solve these issues. Here, we review fine-mapping and gene prioritization approaches that, when combined, will improve the understanding of the underlying mechanisms of complex traits and diseases. Fine-mapping of genetic variants has become increasingly sophisticated: initially, variants were simply overlapped with functional elements, but now the impact of variants on regulatory activity and direct variant-gene 3D interactions can be identified. Moreover, gene manipulation by CRISPR/Cas9, the identification of expression quantitative trait loci and the use of co-expression networks have all increased our understanding of the genes and pathways affected by GWAS loci. However, despite this progress, limitations including the lack of cell-type- and disease-specific data and the ever-increasing complexity of polygenic models of traits pose serious challenges. Indeed, the combination of fine-mapping and gene prioritization by statistical, functional and population-based strategies will be necessary to truly understand how GWAS loci contribute to complex traits and diseases.
Migratory lineages rapidly evolve larger body sizes than non-migratory relatives in ray-finned fishes

Migratory animals respond to environmental heterogeneity by predictably moving long distances in their lifetime. Migration has evolved repeatedly in animals, and many adaptations are found across the tree of life that increase migration efficiency. Life-history theory predicts that migratory species should evolve a larger body size than non-migratory species, and some empirical studies have shown this pattern. A recent study analysed the evolution of body size between diadromous and non-diadromous shads, herrings, anchovies and allies, finding that species evolved larger body sizes when adapting to a diadromous lifestyle. It remains unknown whether different fish clades adapt to migration similarly. We used an adaptive landscape framework to explore body size evolution for over 4500 migratory and non-migratory species of ray-finned fishes. By fitting models of macroevolution, we show that migratory species are evolving towards a body size that is larger than non-migratory species. Furthermore, we find that migratory lineages evolve towards their optimal body size more rapidly than non-migratory lineages, indicating body size is a key adaption for migratory fishes. Our results show, for the first time, that the largest vertebrate radiation on the planet exhibited strong evolutionary determinism when adapting to a migratory lifestyle.
Integrated Hypothalamic Transcriptome Profiling Reveals the Reproductive Roles of mRNAs and miRNAs in Sheep

Early studies have provided a wealth of information on the functions of microRNAs (miRNAs). However, less is known regarding their functions in the hypothalamus involved in sheep reproduction. To explore the potential roles of hypothalamic messenger RNAs (mRNAs) and miRNAs in sheep without FecB mutation, in total, 172 and 235 differentially expressed genes (DEGs) and 42 and 79 differentially expressed miRNAs (DE miRNAs) were identified in polytocous sheep in the follicular phase versus monotocous sheep in the follicular phase (PF vs. MF) and polytocous sheep in the luteal phase versus monotocous sheep in the luteal phase (PL vs. ML), respectively, using RNA sequencing. We also identified several key mRNAs (e.g., POMC, GNRH1, PRL, GH, TRH, and TTR) and mRNA–miRNAs pairs (e.g., TRH co-regulated by oar-miR-379-5p, oar-miR-30b, oar-miR-152, oar-miR-495-3p, oar-miR-143, oar-miR-106b, oar-miR-218a, oar-miR-148a, and PRL regulated by oar-miR-432) through functional enrichment analysis, and the identified mRNAs and miRNAs may function, conceivably, by influencing gonadotropin-releasing hormone (GnRH) activities and nerve cell survival associated with reproductive hormone release via direct and indirect ways. This study represents an integral analysis between mRNAs and miRNAs in sheep hypothalamus and provides a valuable resource for elucidating sheep prolificacy.
To Flex or Rest: Does Adding No-Load Isometric Actions to the Inter-Set Rest Period in Resistance Training Enhance Muscular Adaptations? A Randomized-Controlled Trial

We aimed to investigate the effects of resistance training (RT) combined with no-load isometric actions (iso-holds) during the inter-set recovery period versus RT that involves passive inter-set rest on muscular strength, muscular hypertrophy, and muscular endurance in resistance-trained men. Twenty-seven resistance-trained male volunteers were randomly assigned to either a traditional group (TRAD) that performed a hypertrophy-oriented RT routine with the rest intervals spent passively (n = 13) or to a group that supplemented traditional RT with iso-holds (ISO) for the working muscle group between each set (n = 14). Training for both routines consisted of three weekly sessions performed for 8 weeks. Three sets of 8–12 repetitions were performed per exercise. A 2-min rest interval was afforded between sets; the ISO group performed iso-holds for the first 30 s of each rest interval and then recovered for the final 90 s. Maximal strength was assessed using the one repetition maximum (1RM) tests in the leg press and bench press. Upper-body muscle endurance was assessed by performing the bench press to failure at 50% of 1RM. Muscle thickness (MT) of the elbow flexors, elbow extensors, mid-thigh, and lateral thigh was assessed using B-mode ultrasound. Results indicated a favorable effect of ISO on MT in the mid-thigh. Alternatively, there was a possible detrimental effect for ISO on leg press strength. No other notable differences were seen between conditions. In conclusion, the use of inter-set iso-holds may be a time-efficient strategy to enhance development of the quadriceps femoris; conversely, it may be detrimental to maximizing lower body strength.
Biostimulant Action of Dissolved Humic Substances From a Conventionally and an Organically Managed Soil on Nitrate Acquisition in Maize Plants

Conversion of conventional farming (CF) to organic farming (OF) is claimed to allow a sustainable management of soil resources, but information on changes induced on dissolved organic matter (DOM) are scarce. Among DOM components, dissolved humic substances (DHS) were shown to possess stimulatory effects on plant growth. DHS were isolated from CF and OF soil leacheates collected from soil monolith columns: first in November (bare soils) and then in April and June (bare and planted soils). DHS caused an enhancement of nitrate uptake rates in maize roots and modulated several genes involved in nitrogen acquisition. The DHS from OF soil exerted a stronger biostimulant action on the nitrate uptake system, but the first assimilatory step of nitrate was mainly activated by DHS derived from CF soil. To validate the physiological response of plants to DHS exposure, real-time RT-PCR analyses were performed on those genes most involved in nitrate acquisition, such as ZmNRT2.1, ZmNRT2.2, ZmMHA2 (coding for two high-affinity nitrate transporters and a PM H+-proton pump), ZmNADH:NR, ZmNADPH:NR, and ZmNiR (coding for nitrate reductases and nitrite reductase). All tested DHS fractions induced the upregulation of nitrate reductase (NR), and in particular the OF2 DHS stimulated the expression of both tested transcripts encoding for two NR isoforms. Characteristics of DHS varied during the experiment in both OF and CF soils: a decrease of high molecular weight fractions in the OF soil, a general increase in the carboxylic groups content, as well as diverse structural modifications in OF vs. CF soils were observed. These changes were accelerated in planted soils. Similarity of chemical properties of DHS with the more easily obtainable water-soluble humic substance extracted from peat (WEHS) and the correspondence of their biostimulant actions confirm the validity of studies which employ WEHS as an easily available source of DHS to investigate biostimulant actions on agricultural crops.