Miracle-dz/UniFAR-FTUs huggingface dataset:
Efficiency improvements for signature schemes with tight security reductions

Much recent work has focused on constructing efficient digital signature schemes whose security is tightly related to the hardness of some underlying cryptographic assumption. With this motivation in mind, we show here two approaches which improve both the computational efficiency and signature length of some recently-proposed schemes:Diffie-Hellman signatures. Goh and Jarecki [18] recently analyzed a signature scheme which has a tight security reduction to the computational Diffie-Hellman problem. Unfortunately, their scheme is less efficient in both computation and bandwidth than previous schemes relying on the (related) discrete logarithm assumption. We present a modification of their scheme in which signing is 33% more efficient and signatures are 75% shorter; the security of this scheme is tightly related to the decisional Diffie-Hellman problem.PSS. The probabilistic signature scheme (PSS) designed by Bellare and Rogaway [3] uses a random salt to enable a tight security reduction to, e.g., the RSA problem. Coron [12] subsequently showed that a shorter random salt can be used without impacting the security of the scheme. We show a variant of PSS which avoids the random salt altogether yet has an equally-tight security reduction. This furthermore yields a version of PSS-R (PSS with message recovery) with optimal message length. Our technique may also be used to improve the efficiency of a number of other schemes.
Temporal patterns of sleep latency in central hypersomnia and attention deficit hyperactivity disorder: a cluster analysis exploration using Multiple Sleep Latency Test

Introduction Excessive daytime sleepiness (EDS) is a crucial symptom that diminishes the quality of life. The primary causes of EDS are central hypersomnia, including narcolepsy type 1 (NT1), type 2 (NT2), and idiopathic hypersomnia (IH). EDS is often associated with other psychiatric disorders, particularly attention deficit hyperactivity disorder (ADHD). The Multiple Sleep Latency Test (MSLT) is the standard assessment tool for EDS. Although the MSLT yields numerous parameters, most are not employed in clinical practice. In this study, we leveraged novel MSLT parameters to discern central hypersomnia and ADHD presence. Our analysis focused on sleep latency variability and employed cluster analysis to identify unique temporal patterns. Methods We examined the MSLT data from 333 patients; of these, 200 (aged 14–54, mean: 24.9 ± 8.1, years; 114 females) met the inclusion criteria comprising comprehensive data an Apnea-Hypopnea Index (AHI) below 5, and no prior diagnosis of sleep apnea syndrome. We employed a time-course cluster approach that specifically targeted sleep latency variability during the MSLT. Results Considering both multiple clustering quality evaluations and the study’s objectives, we identified 9 distinct clusters. Clusters 1 and 3 predominantly had MSLT-positive results; Cluster 2 was entirely MSLT-positive; Clusters 4, 5, 6, 8, and 9 were mainly MSLT-negative; and Cluster 7 had mixed results. The diagnosis of hypersomnia varied notably among Clusters 1, 2, 3, and 7, with Cluster 2 demonstrating a pronounced tendency towards NT1 and NT2 diagnoses (p < 0.005). However, no significant correlation was observed between ADHD diagnoses and specific sleep latency patterns in any cluster. Conclusions Our study highlights the value of time-course clustering in understanding sleep latency patterns of patients with central hypersomnia.
Latent Kullback Leibler Control for Continuous-State Systems using Probabilistic Graphical Models

Kullback Leibler (KL) control problems allow for efficient computation of optimal control by solving a principal eigenvector problem. However, direct applicability of such framework to continuous state-action systems is limited. In this paper, we propose to embed a KL control problem in a probabilistic graphical model where observed variables correspond to the continuous (possibly high-dimensional) state of the system and latent variables correspond to a discrete (low-dimensional) representation of the state amenable for KL control computation. We present two examples of this approach. The first one uses standard hidden Markov models (HMMs) and computes exact optimal control, but is only applicable to low-dimensional systems. The second one uses factorial HMMs, it is scalable to higher dimensional problems, but control computation is approximate. We illustrate both examples in several robot motor control tasks.
The Physical Properties of the Capsular Polysaccharides from Cryptococcus neoformans Suggest Features for Capsule Construction*

The most distinctive feature of the human pathogenic fungus is a polysaccharide capsule that is essential for virulence and is composed primarily of glucuronoxylomannan (GXM) and galactoxylomannan (GalXM). GXM mediates multiple deleterious effects on host immune function, yet relatively little is known about its physical properties. The average mass of Cryptococcus neoformans GXM from four antigenically different strains ranged from 1.7 to 7 × 106 daltons as calculated from Zimm plots of light-scattering data. GalXM was significantly smaller than GXM, with an average mass of 1 × 105 daltons. These molecular masses imply that GalXM is the most numerous polysaccharide in the capsule on a molar basis. The radius of gyration of the capsular polysaccharides ranged between 68 and 208 nm. Viscosity measurements suggest that neither polysaccharide altered fluid dynamics during infection since GXM behaved in solution as a polyelectrolyte and GalXM did not increase solution viscosity. Immunoblot analysis indicated heterogeneity within GXM. In agreement with this, scanning transmission electron microscopy of GXM preparations revealed a tangled network of two different types of molecules. Mass per length measurements from light scattering and scanning transmission electron microscopy were consistent and suggested GXM molecules self-associate. A mechanism for capsule growth is proposed based on the extracellular release and entanglement of GXM molecules.
Neural field dynamics with local and global connectivity and time delay

Spatially continuous networks with heterogeneous connections are ubiquitous in biological systems, in particular neural systems. To understand the mutual effects of locally homogeneous and globally heterogeneous connectivity, we investigate the stability of the rest-state activity of a neural field as a function of its connectivity. The variation of the connectivity is operationalized through manipulation of a heterogeneous two-point connection embedded into the otherwise homogeneous connectivity matrix, as well as by variation of connectivity strength and a finite transmission speed. The latter results in a time delay of communication among individual brain areas. We demonstrate that the local connectivity generates the well-known power-law behaviour of the electroencephalographic power spectrum with an exponent close to −2, whereas the global connections generate a more characteristic line spectrum. These spectral characteristics are routinely observed in large-scale topographies of the human brain.
Combined Effects of Tumor Promoters and Serum on Proliferin mRNA Induction: A Biomarker Sensitive to Saccharin, 2,3,7,8-Tcdd, and Other Compounds at Minimal Concentrations Promoting C3H/10T1/2 Cell Transformation

Increases in proliferin (PLF) gene family mRNA abundance and promotional effects in cell transformation assays are paired responses that follow exposures to diverse chemical and physical agents in the C3H/10T1/2 in vitro model of multi-stage carcinogenesis. This study measured PLF mRNA abundance changes over 1 to 3 d in response to several types of promoters that were previously unassessed for this effect. Saccharin is a known promoter of cell transformation in C3H/10T1/2 cell cultures, but unlike 12-O-tetradecanoylphorbol 13-acetate (TPA) or mezerein, PLF mRNA abundance increases were inconsistently detected following simple addition of saccharin to the culture medium. Consistent effects occurred when pretreatments with promoting concentrations of saccharin or sodium saccharin (1-13 mM) were combined with subsequent additions of serum or complete medium changes. When added at or near their lowest observed effect levels (LOELs) for transformation, other promoters of 10T1/2 cells such as formaldehyde (50-100 w M), diethylstilbesterol (DES) (0.5-30 w M), and 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7,8-TCDD) (4-40 pM) were shown to be inducers of both basal and serum-induced PLF mRNA levels. Acetaldehyde (300-900 w M) was comparable to formaldehyde as an inducer. In contrast to these various promoters, pretreatment with phenobarbital or methanol, both non-promoters in these cells, did not affect serum-induced PLF mRNA levels at concentrations up to 3 mM and 2 M, respectively. The published values for the LOELs of 17 promoters of cell transformation and the LOELs determined to date for PLF mRNA induction were highly correlated over a 1 billion -- fold concentration range. The response of PLF mRNA is a short-term marker sensitive to the active concentration ranges of diverse chemical agents with promotional activity in C3H/10T1/2 cell transformation system.
Health and Economic Consequences of Fragile X Syndrome for Caregivers

Objective: To describe the health and economic burden experienced by caregivers of individuals with fragile X syndrome (FXS) and test the assumption that burden is associated with specific dimensions of problem behavior. Methods: Three hundred fifty caregivers rated their son or daughter’s problem behavior and reported the use of medical services, caregiving time, impact on employment, financial burden, caregiver injuries, caregiver mental health, and prescription drug use. Results: The son's FXS posed a significant burden for caregivers in a number of areas. Visits to medical specialists were common for both males (5.4 per year) and females (5.1 per year). Caregivers reported 9.2 hours per day of family caregiving for males with FXS and an additional 5.5 hours of paid help. Most families reported that FXS had at least some financial impact on the family, and caregivers had to take an average of 19.4 hours from work each month to care for their child’s needs. Almost one third of the caregivers had been injured by their child at least once in the past year; when injuries occurred, the frequency was high (14.7 per year), of which 2.7 required medical care. Approximately one third of the caregivers had seen a professional for anxiety, stress, or depression during the past year, and one fourth were taking medication to help with these symptoms. Caregiver burden was highly associated with problem behavior, most commonly irritability. Conclusion: Problem behavior is a strong contributor to burden experienced by caregivers of children and adults with FXS. Clinicians should be aware of the role problem behavior plays in family adaptation and help families access appropriate medical and social support services.
Deep Intraseasonal Variability in the Central Equatorial Atlantic

Besides the zonal flow that dominates the seasonal and long-term variability in the equatorial Atlantic, energetic intraseasonal meridional velocity fluctuations are observed in large parts of the water column. We use 15 years of partly full-depth velocity data from an equatorial mooring at 23°W to investigate intraseasonal variability and specifically the downward propagation of intraseasonal energy from the near-surface into the deep ocean. Between 20 and 50 m, intraseasonal variability at 23°W peaks at periods between 30 and 40 days. It is associated with westward-propagating tropical instability waves, which undergo an annual intensification in August. At deeper levels down to about 2000 m considerable intraseasonal energy is still observed. A frequency–vertical mode decomposition reveals that meridional velocity fluctuations are more energetic than the zonal ones for periods < 50 days. The energy peak at 30–40 days and at vertical modes 2–5 excludes equatorial Rossby waves and suggests Yanai waves to be associated with the observed intraseasonal energy. Yanai waves that are considered to be generated by tropical instability waves propagate their energy from the near-surface west of 23°W downward and eastward to eventually reach the mooring location. The distribution of intraseasonal energy at the mooring position depends largely on the dominant frequency and the time, depth, and longitude of excitation, while the dominant vertical mode of the Yanai waves plays only a minor role. Observations also show the presence of weaker intraseasonal variability at 23°W below 2000 m that cannot be associated with tropical instability waves.
Facilitation between woody and herbaceous plants that associate with arbuscular mycorrhizal fungi in temperate European forests

Abstract In late‐successional environments, low in available nutrient such as the forest understory, herbaceous plant individuals depend strongly on their mycorrhizal associates for survival. We tested whether in temperate European forests arbuscular mycorrhizal (AM) woody plants might facilitate the establishment of AM herbaceous plants in agreement with the mycorrhizal mediation hypothesis. We used a dataset spanning over 400 vegetation plots in the Weser‐Elbe region (northwest Germany). Mycorrhizal status information was obtained from published resources, and Ellenberg indicator values were used to infer environmental data. We carried out tests for both relative richness and relative abundance of herbaceous plants. We found that the subset of herbaceous individuals that associated with AM profited when there was a high cover of AM woody plants. These relationships were retained when we accounted for environmental filtering effects using path analysis. Our findings build on the existing literature highlighting the prominent role of mycorrhiza as a coexistence mechanism in plant communities. From a nature conservation point of view, it may be possible to promote functional diversity in the forest understory through introducing AM woody trees in stands when absent.
Denileukin diftitox for the treatment of CD25 low-expression mycosis fungoides and Sézary syndrome

In a placebo-controlled study, denileukin diftitox (DD) was effective against cutaneous T-cell lymphoma (CTCL) expressing CD25. An open-label companion study examined the efficacy and safety of DD in 36 patients with skin biopsies containing < 20% CD25 cells by immunohistochemistry staining (CD25 low expression). Patients received DD 18 μg/kg/day for 5 consecutive days every 3 weeks for up to eight courses. The primary endpoint, overall response rate, was 30.6% (95% confidence interval: 16.3, 48.1), 33.3% for stage IIA or lower disease, and 26.7% for stage IIB or greater disease. Median progression-free survival (PFS) was > 487 days, and median time to treatment failure was 68.5 days. No difference in PFS by disease stage was observed. The safety profile of DD in CD25 low-expression disease was similar to that in CD25+ disease. These findings suggest that CD25 low expression does not preclude a meaningful clinical response to DD in patients with CTCL.
Groundwater isoscapes in a montane headwater catchment show dominance of well‐mixed storage

We conducted an integrated groundwater–surface water monitoring programme in a 3.2‐km2 experimental catchment in the Scottish Highlands by sampling all springs, seepages, and wells in six, spatially extensive synoptic surveys over a 2‐year period. The catchment has been glaciated, with steep hillslopes and a flat valley bottom. There is around 70% glacial drift cover in lower areas. The solid geology, which outcrops at higher elevations, is granite and metamorphic schist. The springs and seepages generally occur at the contact between the solid geology and drift or at breaks of slopes in the valley bottom. Samples were analysed for stable isotopes, Gran alkalinity and electrical conductivity. Despite the surveys encompassing markedly different antecedent conditions, the isotopic composition of groundwater at each location exhibited limited temporal variability, resulting in a remarkable persistence of spatial patterns indicating well‐mixed shallow, groundwater stores. Moreover, line‐conditioned excess values derived from the isotope data indicated no evidence of fractionation affecting the groundwater, which suggests that most recharge occurs in winter. The alkalinity and electrical conductivity of groundwater reflected geological differences in the catchment, being highest where more weatherable calcareous rocks outcrop at higher altitudes in the catchment. Springs draining these areas also had the most variable isotope composition, which indicated that they have shorter residence times than the drift covered part of the catchment. The study showed that even in geologically heterogeneous upland catchments, groundwater can be characterized by a consistent isotopic composition, reflecting rapid mixing in the recharge zone. Our work, thus, emphasizes the critical role of groundwater in upland catchments and provides tracer data that can help constrain quantitative groundwater models.
Soil loss: Effect of plant litter incorporation rate under simulated rainfall conditions

Plant litter can control land degradation by increasing soil organic matter and decreasing soil erosion by covering the soil surface or being incorporated into topsoil. However, the effect of litter incorporation on soil erosion is not clear. This study aimed to investigate the effect of litter incorporation into topsoil on interrill erosion. The poorly decomposed litter was collected from the field and incorporated into topsoil (5 cm) at six rates (ranging from 0 to 0.5 kg m−2). Laboratory rainfall (80 mm hr−1) experiments were conducted under five slope gradients (ranging from 9% to 47%). The results showed that the soil loss rates declined exponentially with increase in litter incorporation rate on slope gradients between 9% and 36%. However, on slope gradient of 47%, litter incorporation caused an increase in the soil loss rate. The efficiency of litter incorporation in controlling soil loss varied from −21.7% to 40.5% with a mean of 10.8%. It decreased linearly with the slope gradient (R2 = 0.34). The decrease can be explained by two simultaneous but opposite effects: the effect of preventing erosion and that of promoting erosion. The former was induced by decreases in the effective erosive force of raindrop and overland flow exerted on soil, and soil erodibility, along with increases in sediment interception. The latter was caused by rapid saturation of the surface soil and concentrated overland flow. The results demonstrate the complexity of the effect of litter incorporation on soil erosion and can improve our understanding of litter in soil loss control.
Reinforcement Learning Based Argument Component Detection

Argument component detection (ACD) is an important sub-task in argumentation mining. ACD aims at detecting and classifying different argument components in natural language texts. Historical annotations (HAs) are important features the human annotators consider when they manually perform the ACD task. However, HAs are largely ignored by existing automatic ACD techniques. Reinforcement learning (RL) has proven to be an effective method for using HAs in some natural language processing tasks. In this work, we propose a RL-based ACD technique, and evaluate its performance on two well-annotated corpora. Results suggest that, in terms of classification accuracy, HAs-augmented RL outperforms plain RL by at most 17.85%, and outperforms the state-of-the-art supervised learning algorithm by at most 11.94%.
A hybrid cascaded multilevel inverter

A hybrid cascaded multilevel inverter for interfacing with renewable energy resources is developed. The objective of this research is to propose an alternative topology of hybrid cascaded multilevel inverter applications. The modified PWM technique is also developed to reduce switching losses. Also, the proposed topology can reduce the number of required power switches compared to a traditional cascaded multilevel inverter. PSIM (PowerSim) and Simulink/MATLAB are used to simulate the circuit operation and control signal. The 3-kW prototype is developed. The reduced switching losses of the proposed multilevel inverter are also discussed. The results show that this alternative topology can be applied for high power applications.
Query Segmentation Based on Eigenspace Similarity

Query segmentation is essential to query processing. It aims to tokenize query words into several semantic segments and help the search engine to improve the precision of retrieval. In this paper, we present a novel unsupervised learning approach to query segmentation based on principal eigenspace similarity of query-word-frequency matrix derived from web statistics. Experimental results show that our approach could achieve superior performance of 35.8% and 17.7% in F-measure over the two baselines respectively, i.e. MI (Mutual Information) approach and EM optimization approach.
The Value of Fundoscopy in General Practice

BACKGROUND Many of the common systemic diseases present characteristic changes in the fundus of the eye, but fundoscopy is often performed by an ophthalmologist. Our purpose was to assess the value of fundoscopy for the general practitioners (GPs) regarding the diagnosis and management of the cases which they face in daily practice. METHODS 689 patients were referred by GPs to the outpatient ophthalmology department for fundoscopy during the year 2010. The causes of this referral, the results of ophthalmoscopy and its significance in the final diagnosis were recorded and analyzed. RESULTS In 22 patients (3.1%), fundoscopy revealed optic disc edema. In 7 patients with head trauma (9.7%), fundoscopy revealed intravitreous haemorrhage and Berlin edema. From the patients with photopsias or floaters, 5 (10.2%) had retinal detachment. Finally, in cases with diabetes mellitus or hypertension, ophthalmoscopy was very important to detect the existence and grade the degree of diabetic or hypertensive retinopathy, if they appeared, and as a result to evaluate the prognosis of the disease. CONCLUSIONS Fundoscopy is fundamental for the GP, as it may help to confirm or exclude the diagnosis of many common diseases. Nevertheless, there are clinical entities where ophthalmoscopy should be performed by an ophthalmologist, in order to be more specific and accurate, and GP should be able to recognise these cases.