Miracle-dz/UniFAR-FTUs huggingface dataset:
Structural studies of aqueous solutions of PEO - PPO - PEO triblock copolymers, their micellar aggregates and mesophases; a small-angle neutron scattering study

The structural characteristics of aqueous solutions of the Pluronic triblock copolymers of poly(ethylene oxide) - poly(propylene oxide) - poly(ethylene oxide), PEO - PPO - PEO, and their self-associated assemblies are reviewed. It is shown by small-angle neutron scattering that at low temperatures and/or concentration the individual copolymers exist in solution as individual unimers. Thermodynamically stable micelles are formed with increasing copolymer concentration and/or temperature. The unimer-to-micelle transition is not sharp, however. Micelles of well defined spherical shape and size coexist with unimers over a relatively wide temperature/concentration range. The micellar volume fraction increases accordingly with increasing temperature, increasing copolymer concentration and decreasing hydrostatic pressure. The copolymer suspension undergoes as a result a transition from a Newtonian liquid to a soft solid material when the micellar volume fraction crosses the critical value for hard-sphere crystallization. Crystallographic investigations on shear-aligned monodomain samples prove that the micelles in the solid phase are organized on a body-centred cubic lattice. As a result of an increasing micellar size upon increasing the temperature, the micelles themselves undergo a sphere-to-rod transition at elevated temperatures. In a shear field these rod-like micelles form a macroscopic nematic phase for low copolymer concentration, and a hexagonal solid phase for higher concentrations. For even higher concentrations, lamellar phases are observed: one lamellar type which is still governed by the hydrophobic interactions, and one type which appears as a result of crystallization of the PEO blocks.
Third-Generation Behavioural Therapies in the Context of Neurodevelopmental Problems and Intellectual Disabilities: A Randomised Clinical Trial with Parents

The purpose of this study was to examine how 14 parents of children with autism and intellectual impairments responded to an Acceptance and Commitment Therapy (ACT)-based psychological flexibility intervention programme. A randomised clinical trial was conducted. Parents were randomly assigned to the training programme group (n = 8) or waiting list group (n = 6). The treatment effect was measured using the 6-PAQ, PSS-14, GHQ-12, and WBSI questionnaires. Changes in interactions were assessed through self-recording, including a baseline to observe the previous functioning. Measures were taken before and after the application of the intervention programme and three months later. After that, the control group was switched to the psychological flexibility programme condition. After the programme’s implementation, we could see a reduction in stress and the tendency to suppress unwanted private events. The impacts also appeared to apply to family interactions, resulting in a rise in positive interactions and a decrease in unfavourable ones. The results led us to think about the importance of psychological flexibility for the parents of children with chronic conditions, facilitating a reduction in the emotional impact derived from parenting and the emission of behaviours that promote the harmonious development of the diagnosed child.
Uniform Airy-type expansions of integrals

A new method for representing the remainder and coefficients in Airy-type expansions of integrals is given. The quantities are written in terms of Cauchy-type integrals and are natural generalizations of integral representations of Taylor coefficients and remainders of analytic functions. The new approach gives a general method for extending the domain of the saddle-point parameter to unbounded domains. As a side result the conditions under which the Airy-type asymptotic expansion has a double asymptotic property become clear. An example relating to Laguerre polynomials is worked out in detail. How to apply the method to other types of uniform expansions, for example, to an expansion with Bessel functions as approximants, is explained. In this case the domain of validity can be extended to unbounded domains and the double asymptotic property can be established as well.
Parenting Stress, Child Social Functioning, and Part C Early Intervention in Predominantly Low-Income Families of Children With or at High Risk for Developmental Delay From Minoritized Racial and Ethnic Groups

In this study, the relationships between child social functioning, parenting stress, and Part C Early Intervention (EI) enrollment were examined in 227 ethnically and racially diverse, low-income families of 15- to 27-month-old children. All toddlers in the sample were identified with or at high risk for developmental delay via universal screening in primary care; 41.4% were enrolled in EI at the time of study data collection and 83.3% ultimately enrolled in EI before turning 3 years old. Generalized linear mixed model results indicated no direct relationship between EI enrollment and parenting stress, but a significant inverse association was found between child social functioning and parenting stress (β = −0.61, p = .005) that was moderated by EI enrollment (p < .001). This suggests potential benefits of timely referral and access to EI for families of children at risk of developmental delay in historically underserved communities. Furthermore, exploratory bivariate analyses indicated that clinically elevated parenting stress related to higher worry about the child’s development and higher M-CHAT-R/F scores; EI enrollment was related to parents not working outside the home, older age of both parent and child, and lower child social functioning level.
Influence of Ovarian Status and Steroid Hormone Concentration on Day of Timed Artificial Insemination (TAI) on the Reproductive Performance of Dairy Cows Inseminated with Sexed Semen

Simple Summary The use of sexed semen results in a decrease in the number of cows required for progeny testing, the fast production of replacement dairy heifers and a significant reduction in the herd renewal period. Due to some of the disadvantages of sex-sorted semen, such as lower concentration, morphological damage and sperm of lower fertility, there are many problems related to the selection of animals appointed to estrus synchronization programs for artificial insemination with sexed semen. The present study showed a strong relationship between ovarian status, the size of the PF and the estradiol and progesterone concentrations on the day of TAI and the reproductive performance of dairy cows, irrespective of the estrus synchronization treatment used. In this context, the simple and cost-effective ultrasound examination of cows’ ovaries on the day of TAI can be a reliable tool for the selection of candidates for sex-sorted semen application. Abstract This study aimed to evaluate the effect of the ovarian status and steroid hormone concentration on the day of TAI on the reproductive performance of dairy cows subjected to estrus synchronization treatment and timed artificial insemination with sexed semen. Seventy-eight cyclic Holstein cows pre-treated with PGF2α-GnRH were divided in two groups—I (Preselect-OvSynch, n = 38) and II (OvSynch+PRID-7-day+eCG, n = 40)—and inseminated with sexed semen. The presence of preovulatory follicle (PF) with or without corpus luteum (CL), the PF diameter, the estradiol (E2) and progesterone (P4) concentrations on the day of TAI, the pregnancy rate (PR) and embryo loss were determined. On the day of TAI, 78.4% of all the pregnant cows presented a PF (mean size 1.80 ± 0.12 cm) without CL, low P4 (0.59 ± 0.28 ng/mL) and high E2 (12.35 ± 2.62 pg/mg) concentrations. The positive correlation between the size of the PF and the level of E2 in the pregnant cows from group II was stronger than that of group I (R = 0.82 vs. R = 0.52, p < 0.05). The pregnancy rate on day 30 (57.5% vs. 36.8%) and day 60 (50% vs. 26.3%; p < 0.05) and the embryo losses (13% vs. 28.5%) showed better effects of treatment in group II. In conclusion, the ovarian status and the steroid hormone concentration on the day of TAI influence the pregnancy rates of dairy cows subjected to estrus synchronization and timed artificial insemination with sexed semen.
The effects of an elastic solid surface layer on the radial pulsations of gas bubbles

Most previous theoretical investigations of gas bubble dynamics have assumed an uncontaminated gas–liquid interface. Recently, however, the potential importance of layers of surface active agents on bubble dynamics has been increasingly recognized. In this work it is assumed that a continuous layer of incompressible, solid elastic material separates the gas from the bulk Newtonian liquid. Elasticity is modeled to include viscous damping. A Rayleigh–Plesset‐like equation describing the dynamics of such surface‐contaminated gas bubbles is derived. The equation predicts that the surface layer supports a strain that counters the Laplace pressure and thereby stabilizes the bubble against dissolution. An analytical solution to this equation which includes both the fundamental and second‐harmonic response is presented. The dispersion relation describing the propagation of linear pressure waves in liquids containing suspensions of these bubbles also is presented. It is found that (1) the resonance frequencies of .
First report on the enzymatic and immune response of Metarhizium majus bag formulated conidia against Spodoptera frugiperda: An ecofriendly microbial insecticide

Entomopathogenic fungi from microbial sources are a powerful tool for combating insecticide resistance in insect pests. The purpose of the current study was to isolate, identify, and evaluate bag-formulated entomopathogenic fungal conidial virulence against insect pests. We further investigated the enzymatic responses induced by the entomopathogenic fungi as well as the effect on a non-target species. Entomopathogenic fungi were isolated from the Palamalai Hills, India, using the insect bait method, and the Metarhizium majus (MK418990.1) entomopathogen was identified using biotechnological techniques (genomic DNA isolation and 18S rDNA amplification). Bag-formulated fungal conidial efficacy (2.5 × 103, 2.5 × 104, 2.5 × 105, 2.5 × 106, and 2.5 × 107 conidia/ml) was evaluated against third instar larvae of Spodoptera frugiperda at 3, 6, 9, and 12 days of treatment, and acid and alkaline phosphatases, catalase, and superoxide dismutase enzymatic responses were evaluated at 3 days post-treatment. After 12 days of treatment, non-target assays on the earthworm Eudrilus eugeniae were performed using an artificial soil assay. Results of the bag formulated fungal conidial treatment showed that S. frugiperda had high susceptibility rates at higher concentrations (2.5 × 107 conidia/ml) of M. majus. Lower concentration of 2.5 × 103 conidia/ml caused 68.6% mortality, while 2.5 × 107 conidia/ml caused 100% mortality at 9 days post treatment. Investigation into enzymatic responses revealed that at 3 days post M. majus conidia exposure (2.5 × 103 conidia/ml), insect enzyme levels had significantly changed, with acid and alkaline phosphatases, and catalase enzymes significantly reduced and superoxide dismutase enzymes significantly raised relative to the control. After 12 days of treatment, no sublethal effects of M. majus conidia were observed on E. eugeniae, with no observed damage to gut tissues including lumen and epithelial cells, the nucleus, setae, coelom, mitochondria, and muscles. This study offers support for the use of fungal conidia in the target-specific control of insect pests.
An efficient algorithm to design perfect reconstruction regular quadrature mirror filters using weighted L/sub p/ error criteria

An efficient iterative algorithm is presented in this paper to design lattice-type perfect reconstruction regular quadrature mirror filters (PR-QMF) by minimizing the pth power of an appropriate error criteria, where p can be a function of /spl omega/. The filter bank design is approximated as an unconstrained weighted least squares problem with respect to the lattice coefficients. Typically, only a few iterations of our algorithm are needed to obtain an optimal solution in the weighted L/sub p/ sense. An estimation of the number of canonic signed digit (CSD) terms needed to quantize the lattice coefficients yielding minimal degradation of the filter's stopband attenuation is also derived. Efficient multiplierless implementation of lattice-type regular PR-QMF banks are easily obtained using this result.
Whistler-mode chorus and morningside aurorae

Quasi-electrostatic ELF/VLF chorus emissions immediately above the equatiorial half-gyrofrequency, observed to propagate with wave normal angle (Ψ) within 0.4–1.2° of the resonance cone (Ψr) [Muto et al., 1987], are shown to efficiently resonate with 0.1–10 keV electrons. These waves may thus be important in driving the relatively low energy (<10 keV) component of pulsating aurorae and the morning-side diffuse aurorae (∼1 keV).
Plausible Role of Stem Cell Types for Treating and Understanding the Pathophysiology of Depression

Major Depressive Disorder (MDD), colloquially known as depression, is a debilitating condition affecting an estimated 3.8% of the population globally, of which 5.0% are adults and 5.7% are above the age of 60. MDD is differentiated from common mood changes and short-lived emotional responses due to subtle alterations in gray and white matter, including the frontal lobe, hippocampus, temporal lobe, thalamus, striatum, and amygdala. It can be detrimental to a person’s overall health if it occurs with moderate or severe intensity. It can render a person suffering terribly to perform inadequately in their personal, professional, and social lives. Depression, at its peak, can lead to suicidal thoughts and ideation. Antidepressants manage clinical depression and function by modulating the serotonin, norepinephrine, and dopamine neurotransmitter levels in the brain. Patients with MDD positively respond to antidepressants, but 10–30% do not recuperate or have a partial response accompanied by poor life quality, suicidal ideation, self-injurious behavior, and an increased relapse rate. Recent research shows that mesenchymal stem cells and iPSCs may be responsible for lowering depression by producing more neurons with increased cortical connections. This narrative review discusses the plausible functions of various stem cell types in treating and understanding depression pathophysiology.
Geometrical optical approach for electromagnetic wave propagation in rectangular mine tunnels

Electromagnetic wave propagation inside an empty rectangular mine tunnel with imperfect walls is considered. The modal expansion of the fields is complicated by the coupling of the basic modes by the imperfect walls. To avoid this difficulty, and in view of the large guide dimensions relative to the free space wavelength, a geometrical ray approach is proposed. To provide a theoretical foundation for the method, we first consider an idealized waveguide model with two perfectly reflecting side walls. The modal field expansion for this prototype model is fully analyzed to provide a satisfactory comparison between the modal and the geometrical ray sums. The proposed general ray method is then applied to the rectangular waveguide when all four walls are imperfectly conducting. Finally, the influence of wall roughness is considered by a relatively simple method.
Fiber-coupled erbium microlasers on a chip

An erbium-doped, toroid-shaped microlaser fabricated on a silicon chip is described and characterized. Erbium-doped sol-gel films are applied to the surface of a silica toroidal microresonator to create the microcavity lasers. Highly confined whispering gallery modes make possible single-mode and ultralow threshold microlasers.
Growth Pattern Fingerprinting for Automatic Analysis of Lung Adenocarcinoma Overall Survival

Lung adenocarcinoma (LUAD) tumour tissue grows into variable morphological architecture called growth patterns (GPs). The GPs are clinically linked to the biological behaviour of the tumour. However, due to the complex heterogeneity of the tumours, there is high inter-and intra-observer variability in the pathologist reporting of GPs. This paper proposes a deep-learning model for automatically classifying the LUAD growth patterns in whole slide images (WSIs). The model is trained and tested on 78 cases of LUAD in the digitised WSI of the sample. For each case, all the growth patterns were automatically classified and quantified. Our multivariate analysis shows that lepidic and micropapillary patterns are independent predictors for five-year survival (p < 0.05). The proposed model splits our study cohort into short- and long-term survival with p=0.009.
A model for the Barkhausen noise power as a function of applied field and stress (abstract)

The model of Alessandro et al.1 is used to derive the Barkhausen noise power in terms of permeability μ, which is really the irreversible permeability, since the Barkhausen noise is produced by the irreversible motion of domain walls. From the model expression, it is shown that the peak in the Barkhausen noise power as a function of applied field coincides with the peak in the irreversible permeability. From the magnetomechanical hysteresis model,2 an expression for the irreversible permeability is found and shown to peak at a higher magnetic field than the total permeability. Using the magnetomechanical hysteresis model and the derived expression from the Alessandro model, the Barkhausen noise power peak value is computed and found to increase almost linearly from negative (compressive) to positive (tensile) stress, with slightly decreased slope at high positive and negative values of stress, in agreement with trends in experimental observations.3,4 Dependence of the Barkhausen noise power on H, the tim.
Physicochemical and Functional Changes in Lotus Root Polysaccharide Associated with Noncovalent Binding of Polyphenols

To promote the functional applications of lotus root polysaccharides (LRPs), the effects of noncovalent polyphenol binding on their physicochemical properties, as well as antioxidant and immunomodulatory activities, were investigated. Ferulic acid (FA) and chlorogenic acid (CHA) were spontaneously bound to the LRP to prepare the complexes LRP-FA1, LRP-FA2, LRP-FA3, LRP-CHA1, LRP-CHA2 and LRP-CHA3, and their mass ratios of polyphenol to LRP were, respectively, 121.57, 61.18, 34.79, 2359.58, 1276.71 and 545.08 mg/g. Using the physical mixture of the LRP and polyphenols as a control, the noncovalent interaction between them in the complexes was confirmed by ultraviolet and Fourier-transform infrared spectroscopy. The interaction increased their average molecular weights by 1.11~2.27 times compared to the LRP. The polyphenols enhanced the antioxidant capacity and macrophage-stimulating activity of the LRP depending on their binding amount. Particularly, the DPPH radical scavenging activity and FRAP antioxidant ability were positively related to the FA binding amount but negatively related to the CHA binding amount. The NO production of the macrophages stimulated by the LRP was inhibited by the co-incubation with free polyphenols; however, the inhibition was eliminated by the noncovalent binding. The complexes could stimulate the NO production and tumor necrosis factor-α secretion more effectively than the LRP. The noncovalent binding of polyphenols may be an innovative strategy for the structural and functional modification of natural polysaccharides.
Clinicians' preferences for managing aneurysmal subarachnoid hemorrhage using endothelin receptor antagonists

Background The endothelin receptor antagonist (ERA) clazosentan is being investigated for the medical prevention of cerebral vasospasm and associated complications, such as delayed cerebral ischemia (DCI), after aneurysmal subarachnoid hemorrhage (aSAH). This study quantified how clinicians weigh the benefits and risks of ERAs for DCI prevention to better understand their treatment needs and expectations. Methods An online choice experiment was conducted to elicit preferences of neurologists, intensivists, and neurosurgeons treating aSAH in the US and UK for the use of ERAs. The design of the choice experiment was informed by a feasibility assessment (N = 100), one-on-one interviews with clinicians (N = 10), a qualitative pilot (N = 13), and a quantitative pilot (N = 50). Selected treatment attributes included in the choice experiment were: one benefit (likelihood of DCI); and three risks (lung complications, hypotension, and anemia). In the choice experiment, clinicians repeatedly chose best and worst treatment options based on a scenario of a patient being treated in the ICU after aneurism repair. A correlated mixed logit model determined the relative attribute importance (RAI) and associated highest density interval (HDI) as well as acceptable benefit-risk trade-offs. Results The final choice experiment was completed by 350 clinicians (116 neurologists, 129 intensivists/intensive care clinicians, and 105 neurosurgeons; mean age, 47.4 years). Reducing the likelihood of DCI (RAI = 56.5% [HDI, 53.6–59.5%]) had the largest impact on clinicians' treatment choices, followed by avoiding the risks of lung complications (RAI = 29.6% [HDI, 27.1–32.3%]), hypotension (RAI = 9.2% [HDI, 7.5–10.8%]), and anemia (RAI = 4.7% [HDI, 3.7–5.8%]). Clinicians expected the likelihood of DCI to decrease by ≥8.1% for a 20% increase in the risk of lung complications, ≥2.4% for a 20% increase in the risk of hypotension, and ≥1.2% for a 20% increase in the risk of anemia. Conclusions Clinicians were willing to accept certain increased risks of adverse events for a reduced risk of DCI after aSAH. The likelihood of DCI occurring after aSAH can therefore be considered a clinically relevant endpoint in aSAH treatment development. Thus, evaluations of ERAs might focus on whether improvements (i.e., reductions) in the likelihood of DCI justify the risks of adverse events.
Hepatitis B virus and hepatitis D virus infection in women with or at risk for HIV infection in the United States

Hepatitis D virus (HDV) requires co-infection with hepatitis B virus (HBV). Human immunodeficiency virus (HIV) shares transmission routes with these viruses. Among 4,932 US women infected with or at-risk for HIV during 1994–2015, HBV surface antigen (HBsAg) positivity was more common in women with HIV (2.8% vs. 1.2%; p = 0.001); HDV was more common among participants enrolled during 2013–2015 (p = 0.0004) and those with resolved rather than active hepatitis C (1.9% vs. 0.5%; p = 0.02). Among HBsAg-positive women (n = 117), HDV antibody prevalence was 22% and did not vary by HIV status; HDV infection was associated with the presence of advanced fibrosis/cirrhosis at enrollment (adjusted odds ratio, 5.70; 95% confidence interval, 1.46–22.29). Our results demonstrate the importance of HDV testing in HBV-infected US women.