Miracle-dz/UniFAR-FTUs huggingface dataset:
The Infection, Coinfection, and Abundance of Intestinal Protozoa Increase the Serum Levels of IFABP2 and TNF-α in Patients With Rheumatoid Arthritis

Protozoa, nematodes, and platyhelminths are of clinical interest due to their role on the modulation of the immune responses. To determine the frequency of infection by intestinal parasites as well as the status of single or mixed infection (coinfection) and its relation with inflammation and intestinal permeability markers in patients with rheumatoid arthritis (RA), a cross-sectional study was conducted in 18 women diagnosed with RA. A fecal sample of each participant was analyzed for parasitic identification. The DAS28-erythrocyte sedimentation rate score, as well as the serum levels of TNF-α, IL-10, IL-17A, and the intestinal fatty-acid binding protein 2 (IFABP2), was determined through the ELISA technique. The T CD4+ and CD8+ lymphocytes' proportions were determined by flow cytometry. In this study, 50% (n = 9) of the total sample tested were positive to the presence of intestinal protozoa (27% by single infection and 22.2% by coinfection). Blastocystis sp. and Endolimax nana were the most frequently identified protozoa. The serum levels of IFABP2 were increased in patients with infection by protozoa, mainly in those individuals with coinfection and a larger abundance of Blastocystis sp. We found that coinfection by protozoa was related to higher levels of TNF-α and higher frequency of T CD4+ lymphocytes, mainly in patients under antirheumatic treatment. Infection by intestinal protozoa is associated with increased intestinal permeability in patients with RA; thus, infection, coinfection, and abundance of intestinal protozoa should be clinically screened because they could be an associated factor to the clinical variability of the disease.
Mental Health Literacy of Australian Youth Sport Coaches

Sport is an integral part of Australian culture and comprises a significant portion of time for Australian youth. Within Australia, 73.4% of children reported participating in sport once a week in the latest AusPlay survey (Australian Sports Commission, 2016). Sport historically yields positive health benefits for children and adults. The positive benefits of sport can permeate Australian society. For Australian youth, sport improves mood, enhances neurological functioning, combats chronic disease, and improves biopsychosocial development (Australian Sports Commission, 2016). However, recent national inquiries challenged this exclusively positive conception of sport in Australia, finding sports are institutions that can conceal instances of mental health challenges (Australian Human Rights Commission, 2020). Researchers found ranges of psychiatric disorders in youth athletes ranges from 4 to 68% (Elbe and Nylandsted Jensen, 2016). In response to institutional enquiries into mental health within sport, Australian sporting bodies moved to implement mental health first aid programs and initiatives such as the Australian Institute of Sport (Australian Institute of Sport, 2019) Community Custodians program and the AIS mental health referral network. This opinion piece reflects on these programs and explores ways to heighten our awareness of youth athlete mental health, with an emphasis on the role a coach and sport organizations play in identifying and supporting youth athletes in their efforts to address mental health needs.
Case Report: Safety and Efficacy of Omalizumab in a 13-Year-Old Patient With Chronic Spontaneous Urticaria and Type 1 Diabetes

Chronic urticaria (CU) is defined by the presence of itchy wheals, sometimes accompanied by angioedema, lasting for at least 6 weeks. CU is treated with second-generation antihistamines, increased up to four times the normal doses for second-line treatment. Omalizumab (a monoclonal antibody anti-IgE) may be recommended as third-line therapy in children aged over 12 years. Few reports have suggested that glucose homeostasis is impaired in some type 2 diabetic patients receiving omalizumab, and even in non-diabetic patients, fasting blood glucose and HOMA-IR values appeared to be significantly increased. We report the case of a 13-year-old girl with diabetes mellitus type 1 and chronic spontaneous urticaria (CSU) refractory to standard recommended therapy that we treated with omalizumab at a standard recommended dose of 300 mg every 4 weeks. We observed a rapid and complete remission of CSU after treatment with this humanized monoclonal antibody without detrimental effects on the patient’s glucose control especially in terms of HbA1c (glycated hemoglobin), time in glycemic range (TIR), and daily insulin needs.
Linear Mixed-Effect Models Through the Lens of Hardy–Weinberg Disequilibrium

For genetic association studies with related individuals, the linear mixed-effect model is the most commonly used method. In this report, we show that contrary to the popular belief, this standard method can be sensitive to departure from Hardy–Weinberg equilibrium (i.e., Hardy–Weinberg disequilibrium) at the causal SNPs in two ways. First, when the trait heritability is treated as a nuisance parameter, although the association test has correct type I error control, the resulting heritability estimate can be biased, often upward, in the presence of Hardy–Weinberg disequilibrium. Second, if the true heritability is used in the linear mixed-effect model, then the corresponding association test can be biased in the presence of Hardy–Weinberg disequilibrium. We provide some analytical insights along with supporting empirical results from simulation and application studies.
Factors Defining the Association Between Vitamin D and Testosterone in Males With Type 2 Diabetes and Hypogonadism

Objective This study aimed to evaluate Serum 25-hydroxyvitamin D (25[OH]D) levels in diabetic men with and without hypogonadism and figured out the potential factors influencing the connection between vitamin D and testosterone. Methods A total of 367 men with type 2 diabetes mellitus (T2DM) were investigated, including 254 men with normal gonadal function (Group 1) and 113 men with hypogonadism (Group 2). Men with hypogonadism were classified as either hypogonadotropic hypogonadism (Group 2a) or hypergonadotropic hypogonadism (Group 2b). Serum 25(OH)D levels were detected by liquid chromatography-tandem mass spectrometry in all cases. Morning total testosterone (TT), estradiol (E), dehydroepiandrosterone (DHEA), prolactin (PRL), sex hormone-binding globulin (SHBG), luteinizing hormone (LH), follicle-stimulating hormone (FSH), thyroid function, parathyroid and adrenal hormones, fasting blood glucose (FBG), fasting insulin (Fins) and hemoglobin A1c (HbA1c) were also assessed. Results The prevalence of hypovitaminosis D in men with T2DM was up to 96.46%. Serum 25(OH)D levels were significantly lower in men with hypogonadism than those with eugonadism (16.65 ± 6.44 ng/mL vs. 18.17 ± 6.17 ng/mL, P=0.033). The lowest 25(OH)D level was observed in Group 2a (16.22 ± 6.52 ng/mL). After adjustment for the selected factors, serum 25(OH)D concentrations were shown to be positively correlated with TT concentrations (r=0.137, P=0.032). The relationship between 25(OH)D and testosterone was altered by age, duration of T2DM, body mass index, and HbA1c. Serum 25(OH)D level was positively associated with serum TT level in men with age <60 years (r=0.180, P=0.003), or with duration≥5 years (r=0.186, P=0.013), or with body mass index (BMI)≥28kg/m2 (r=0.431, P=0.000), or with HbA1c≥9% (r=0.145, P=0.031). Conclusions These findings indicate that type 2 diabetes patients with hypogonadism have lower 25(OH)D levels than those without hypogonadism. There seems to be a positive association between the serum 25(OH)D and TT levels, which affected by age, duration, BMI, and HbA1c
Exploring the Causal Effects of Circulating ST2 and Galectin-3 on Heart Failure Risk: A Mendelian Randomization Study

Background Heart failure (HF), primarily caused by conditions such as coronary heart disease or cardiomyopathy, is a global health problem with poor prognosis and heavy burden on healthcare systems. As biomarkers of myocardial injury and fibrosis, suppression of tumorigenicity 2 (ST2) and galectin-3 were recommended for prognosis stratification in HF guidelines. However, the causality between these two mediators and HF remains obscure. This study aimed to explore the causal relationship of genetically determined ST2 and galectin-3 with the risk of HF. Methods We used the two-sample Mendelian randomization (MR) method, incorporating available genome-wide association summary statistics, to investigate the causal association of ST2 and galectin-3 with HF risk. We applied inverse-variance weighted analysis as the main method of analysis. Results In our final MR analysis, 4 single-nucleotide polymorphisms (SNPs) of ST2 and galectin-3, respectively, were identified as valid instrumental variables. Fixed-effect inverse variance weighted (IVW) analysis indicated that genetically predicted ST2 and galectin-3 were not causally associated with HF risk 3. [odds ratio (OR) = 0.9999, 95% confidence interval [CI] = 0.9994–1.0004, p = 0.73; OR = 1.0002, 95% CI = 0.9994–1.0010, p = 0.60, respectively]. These findings were robust in sensitivity analyses, including MR-Egger regression and leave-one-out analysis. Conclusion This MR study provided no evidence for the causal effects of ST2 and galectin-3 on HF risk.
COVID-Related Athletic Deaths: Another Perfect Storm?

Despite high cardiorespiratory fitness, athletes of all ages and sex can suffer poor health, including cardiac conditions; some may even die during training or competition. While athletes are often thought of as being very healthy, this is not always the case as many are fit but unhealthy (Maffetone and Laursen, 2015; Scudiero et al., 2021). Sudden cardiac death (SCD) is one example. The causes of SCD in athletes vary, with the estimated incidence of death between 1 in 40,000 to 1 in 80,000 persons (Harmon et al., 2014). The wide range may be due in part to the definitions of SCD; some estimates include only deaths with exertion or shortly (< 1 h) after exertion, others include any SCD in an athlete (exertional or outside of exertion) and exclude those who have been resuscitated from sudden cardiac arrest. In athletes <35 years, inherited cardiac conditions such as hypertrophic cardiomyopathy and anomalous origin of a coronary artery are most common. Athletes >35 years represent the most sudden death cases from atherosclerotic coronary artery disease, which are usually lifestyle related (Lechner et al., 2020). The true incidence of SCD may be unknown and underestimated as current estimates are based largely on case identification through public media reports and estimated participation rates (Harmon et al., 2011). In addition, underreporting in all ages may occur in the context of recreational sports (Marijon et al., 2011). While SCD in athletes is relatively rare, even a single case represents too many, especially considering most are preventable. This article highlights additional risks associated with postCOVID-19 infection and vaccination.
Varying Relationship Between Vascular Plant Leaf Area and Leaf Biomass Along an Elevational Gradient on the Eastern Qinghai-Tibet Plateau

The altitudinal gradient is one of the driving factors leading to leaf trait variation. It is crucial to understand the response and adaptation strategies of plants to explore the variation of leaf traits and their scaling relationship along the altitudinal gradient. We measured six main leaf traits of 257 woody species at 26 altitudes ranging from 1,050 to 3,500 m within the eastern Qinghai-Tibet Plateau and analyzed the scaling relationships among leaf fresh weight, leaf dry weight, and leaf area. The results showed that leaf dry weight increased significantly with elevation, while leaf fresh weight and leaf area showed a unimodal change. Leaf dry weight and fresh weight showed an allometric relationship, and leaf fresh weight increased faster than leaf dry weight. The scaling exponent of leaf area and leaf fresh weight (or dry weight) was significantly greater than 1, indicating that there have increasing returns for pooled data. For α and normalization constants (β), only β of leaf area vs. leaf fresh weight (or dry weight) had significantly increased with altitude. All three paired traits had positive linear relationships between α and β. Our findings suggest that plants adapt to altitudinal gradient by changing leaf area and biomass investment and coordinating scaling relationships among traits. But leaf traits variation had a minor effect on scaling exponent.
Exogenous DCPTA Treatment Increases Mung Bean Yield by Improving Carbon Metabolism Pathway and Up-Regulating Photosynthetic Capacity and Antioxidants

Mung bean is characterized by having a good edible and medicinal value, while its flowers and pods have low production. Being a tertiary amine, DCPTA [2-(3,4-dichlorophenoxy) triethylamine] substantially regulates the growth and development of crops, maintaining production. Yet it is still limited in terms of the regulation of DCPTA on growth and development, including the yield and sugar metabolism of mung bean. In this study, DCPTA was sprayed at the beginning of mung flowering through a two-season cultivation, to assess its effects on the yield, leaf area per plant, plant height, seed setting rate, photosynthesis, chlorophyll content, and endogenous protective enzymes. Experimental results illustrated that relative to the control (CK), the DCPTA application significantly (p < 0.05) improved the yield of Bailv 11 mung bean, which rose to 6.9% in 2020 and 7.8% in 2021, respectively. This effect positively corresponded to a significant (p<0.05) increase in the number of pods and grains per plant and pod setting rate, but a non-significant difference in 1,000-grain weight. DCPA application also increased the area and fresh weight of leaf, mung height, and its organ dry weight (i.e., leaf, branch, and stem). During plant growth over DCPTA application, the increased activities of SOD, POD, and CAT improved the net photosynthetic rate, stomatal conductance, and transpiration. In addition, transcriptome sequencing further demonstrated that DCPTA treatment significantly (p < 0.05) up-regulated the sucrose synthase, invertase, and fructose kinase in all organs (i.e., leaves, pod skins, and grains) of the plant. In particular, this effect was much greater in the sucrose synthesis (i.e., sucrose content) in leaves. Our study, therefore, concludes that DCPTA application promotes the yield of mung bean via likely enhancing its photosynthetic capacity and sucrose synthase, fructokinase, and beta-fructofuranosidase expression regulation.
Immunotherapy in NSCLC Patients With Brain and Leptomeningeal Metastases

Immunotherapy has now been integrated as a treatment strategy for most patients with non-small cell lung cancer (NSCLC). However, the pivotal clinical trials that demonstrated its impressive efficacy often did not include patients with active, untreated brain metastases or leptomeningeal carcinomatosis. Nevertheless, NSCLC is the most common tumor to metastasize to the brain, and patients develop brain and meningeal involvement in approximately 40 and 10% of cases, respectively. Consequently, the appropriate care of these patients is a recurrent clinical concern. Although there are many aspects that would merit further investigation to explain the mechanism of intracranial response to immune checkpoint inhibitors (ICPs), some data suggest that they are able to cross the blood–brain barrier, resulting in local tumor microenvironment modification. This results in a similar clinical benefit in patients with stable, previously treated brain metastases compared to the general population. Despite important limitations, some real-life studies have described that the ICPs’ efficacy was maintained also in less selected patients with untreated or symptomatic brain metastases. In contrast, few data are available about patients with leptomeningeal carcinomatosis. Nevertheless, neurological complications due to ICP treatment in patients with brain metastases have to be evaluated and carefully monitored. Despite the fact that limited data are available in the literature, the purpose of this review is to show that the multimodal treatment of these patients with brain metastases and/or leptomeningeal disease should be discussed during tracing of the history of the disease, participating in the local and possibly systemic control of NSCLC.
Fluctuations in External Peak Demands Across Quarters During Basketball Games

The purpose of this study was to compare external peak demands (PDs) across quarters (Q) in basketball. Thirteen elite, junior, male basketball players were monitored using electronic performance tracking systems. There were studied intervals for different time windows to determine the external PD for distance (m); player load; distance covered in four different zones; accelerations; and decelerations. A mixed linear model was run to identify differences among quarters, and the auto-correlation function was carried out to determine fluctuations across the whole game. The results showed significant differences between Q1 vs. Q2 for distance, player load, and standing–walking distance; between Q1 vs. Q3 for distance, player load, and HSR; between Q1 vs. Q4 for distance, player load, standing–walking, and HSR; and between Q3 vs. Q4 for distance and player load. These findings suggest that external PD for running-based demands (distance, player load, and high-speed running) decrease across basketball games with the most notable declines occurring between the first and fourth quarters. Nevertheless, it is important to note that non-significant differences were found between quarters for several external PD variables (jogging, running, acceleration, and deceleration) across different time windows. Findings from the present study reinforce the importance of considering specific PD variables for different functions due to the specific insight each provides.
Watch and Learn: Athletes Can Improve by Observing the Actions of Others

Athletes spend a lot of time and effort practicing skills to get better at their sports. In addition to physical practice, athletes can use a technique called action observation to help themselves improve. Action observation is the process of watching movement. Humans naturally learn how to perform movements by watching the movements of other people. For example, from an early age, children learn important skills such as walking, throwing, and kicking by seeing other people perform those actions. Research has shown that watching movements activates similar parts of the brain to those that are involved in performing movement. This means watching sports performance might help athletes improve by strengthening the brain areas used when actions are performed. Coaches and sport psychologists use action observation methods, such as live demonstrations and video footage, to help athletes improve their techniques, develop their confidence, and get better at their sports.
Effects of Workplace Gossip on Employee Mental Health: A Moderated Mediation Model of Psychological Capital and Developmental Job Experience

Research has demonstrated the effects of workplace gossip on employees' work attitudes and behaviors. However, little emphasis has been placed on the psychological influence of workplace gossip on employees. The present study investigated the relationships among workplace gossip, psychological capital, and individual mental health. Data were collected in three waves from 222 full-time employees of a Taiwanese tourism company to explore the effect of workplace gossip on employees' mental health. The results suggested that workplace gossip was associated with employees' mental health through psychological capital. Moreover, developmental job experience plays a moderator role in the relationships among workplace gossip, psychological capital, and mental health. A moderated mediation model was also proposed in this study.
Hepatitis B Infection Among Pregnant Women in China: A Systematic Review and Meta-Analysis

Background A study of the current situation and characteristics of hepatitis B virus (HBV) infection among Chinese pregnant women is meaningful to provide baseline information for future research and policy making, with an aim to eliminate HBV in China. Objectives To provide the epidemiological status of HBV infection among pregnant women in China. Methods PubMed, EMbase, The Cochrane Library, and three Chinese databases were searched. Cohort studies and cross-sectional studies on HBV prevalence in Chinese pregnant women, published after 2016, were retrieved. In addition, combined HBV prevalence and 95% confidence interval (CI) were calculated. This research was registered in PROSPERO (CRD42021289123). Main Results A total of 42 studies were included in the study, with a sample size of 4,007,518 cases, and 20 provinces in China. The prevalence of HBV in Chinese pregnant women was 6.64% (95% CI: 5.72–7.57%) during the period between 2016 and 2021. Among HBsAg positive pregnant women, the HBeAg positive rate was 25.80% (95% CI: 22.26–29.69%). Moreover, geographic regions with HBV prevalence ranking from high to low were in western China, eastern China, and central China, successively. Conclusion The prevalence of HBV in Chinese pregnant women is intermediate endemic, although disparities exist between different regions. Among pregnant women with HBV infection, a high proportion of the patients have strong infectivity. Factors affecting HBV prevalence remain controversial, which demands further studies. Systematic Review Registration https://www.crd. york.ac. uk/PROSPERO/, identifier: CRD42021289123.
Understanding the Structure and Energy Transfer Process of Undoped Ultrathin Emitting Nanolayers Within Interface Exciplexes

Organic light-emitting diodes (OLEDs) have great potential for display, lighting, and near-infrared (NIR) applications due to their outstanding advantages such as high efficiency, low power consumption, and flexibility. Recently, it has been found that the ultrathin emitting nanolayer technology plays a key role in OLEDs with simplified structures through the undoped fabricated process, and exciplex-forming hosts can enhance the efficiency and stability of OLEDs. However, the elementary structure and mechanism of the energy transfer process of ultrathin emitting nanolayers within interface exciplexes are still unclear. Therefore, it is imminently needed to explore the origin of ultrathin emitting nanolayers and their energy process within exciplexes. Herein, the mechanism of films growing to set ultrathin emitting nanolayers (<1 nm) and their energy transfer process within interface exciplexes are reviewed and researched. The UEML phosphorescence dye plays a key role in determining the lifetime of excitons between exciplex and non-exciplex interfaces. The exciplex between TCTA and Bphen has longer lifetime decay than the non-exciplex between TCTA and TAPC, facilitating exciton harvesting. The findings will be beneficial not only to the further development of OLEDs but also to other related organic optoelectronic technologies.