Miracle-dz/UniFAR-FTUs huggingface dataset:
Consistency of chronotype measurements is affected by sleep quality, gender, longitude, and latitude

ABSTRACT Chronotype has received increasing research attention. However, there remains some confusion about the influence of gender, age, sleep quality, insomnia severity, longitude, and latitude on the consistency of the chronotype measured by the different tools. Chronotype measurement indicators were collected from 421 participants. The midpoint of sleep for actigraphy (MSF_A), sleep diary (MSF_D), and Munich Chronotype Questionnaire (MCTQ) (MSFsc) on free days and the Morningness-Eveningness Questionnaire (rMEQ) scores were used to measure the chronotype. In addition, demographic information, Pittsburgh Sleep Quality Index (PSQI), and Insomnia Severity Index (ISI) were also collected. A significant correlation was identified between the questionnaires (MSF_D, MSFsc, rMEQ) and actigraphy (MSF_A) as measures of chronotype. MSF_A was associated with sleep latency and sleep disturbance in the PSQI subdimensions. The correlation between MS_D and sleep disturbance was significant. Both rMEQ and MSFsc were significantly correlated with PSQI (total scores and daytime dysfunction) and ISI. The consistency of all chronotype measurements for the questionnaires and actigraphy was influenced by gender. Among them, MSF_D is also affected by age, while only the latitude and sleep disturbance effect was found in the MSFsc. The influence of age, gender, sleep quality, and latitude should be emphasized when measuring the chronotype using self-reported methods.
Sudden cardiac arrest in athletes and strategies to optimize preparedness

Sudden cardiac arrest (SCA) is the leading cause of death in young athletes. Despite efforts to improve preparedness for cardiac emergencies, the incidence of out‐of‐hospital cardiac arrests in athletes remains high, and bystander awareness and readiness for SCA support are inadequate. Initiatives such as designing an emergency action plan (EAP) and mandating training in cardiopulmonary resuscitation (CPR) and automated external defibrillator use (AED) for team members and personnel can contribute to improved survival rates in SCA cases. This review provides an overview of SCA in athletes, focusing on identifying populations at the highest risk and evaluating the effectiveness of different screening practices in detecting conditions that may lead to SCA. We summarize current practices and recommendations for improving the response to SCA events, and we highlight the need for ongoing efforts to optimize preparedness through the implementation of EAPs and the training of individuals in CPR and AED use. Additionally, we propose a call to action to increase awareness and training in EAP development, CPR, and AED use for team members and personnel. To improve outcomes of SCA cases in athletes, it is crucial to enhance bystander awareness and preparedness for cardiac emergencies. Implementing EAPs and providing training in CPR and AED use for team members and personnel are essential steps toward improving survival rates in SCA cases.
Regional Analysis of Intact and Defective HIV Proviruses in the Brain of Viremic and Virally Suppressed People with HIV

Here, we provide the first regional analysis of intact and defective HIV reservoirs within the brain. Brain tissue from both viremic and virally suppressed people with HIV (PWH) harbored HIV pol DNA in all regions tested, with lower levels present in basal ganglia and cerebellum relative to frontal white matter. Intact proviruses were primarily found in the frontal white matter but also detected in other brain regions of PWH, demonstrating frontal white matter as a major brain reservoir of intact, potentially replication competent HIV DNA that persists despite antiretroviral therapy. ANN NEUROL 2023;94:798–802
Efficacy, mechanism, and safety of melatonin‐loaded on thermosensitive nanogels for rabbit VX2 tumor embolization: A novel design

Transarterial chemoembolization (TACE) has been widely used for hepatocellular carcinoma. Reducing hypoxia in the tumor microenvironment after TACE remains a challenge as tumor progression is common in post‐TACE patients due to the hypoxic tumor microenvironment. In this study, melatonin loaded on p(N‐isopropyl‐acrylamide‐co‐butyl methylacrylate) (PIB‐M) was used for tumor embolism. Two types of human hepatoma cell lines were used to explore the mechanism by which melatonin prevents the growth and metastasis of cancer cells in vitro. A VX2 rabbit tumor model was used to evaluate the efficacy, mechanism, and safety of PIB‐M in vivo. We found that under hypoxic condition, melatonin could inhibit tumor cell proliferation and migration by targeting hypoxia inducible factor‐1α (HIF‐1α) and vascular endothelial growth factor A (VEGF‐A) in vitro. In vivo, PIB‐M inhibited tumor growth and metastasis in rabbit VX2 tumors by promoting apoptosis of tumor cells and targeting related angiogenic proteins and vascular permeability proteins. A high concentration of melatonin in the PIB‐M group could be maintained in tumor tissue for 72 h after embolization. The liver and kidney functions were most damaged on the first day but recovered to normal on the seventh day after embolization in the PIB‐M group. This novel method may open avenues for reduction of tumor growth and metastasis after TACE and is efficacy and safety, which may be used for treatment for other solid tumors and clinical translation.
The Elements of Intelligence

Can machines ever be sentient? Could they perceive and feel things, be conscious of their surroundings? What are the prospects of achieving sentience in a machine? What are the dangers associated with such an endeavor, and is it even ethical to embark on such a path to begin with? In the series of articles of this column, I discuss one possible path toward “general intelligence” in machines: to use the process of Darwinian evolution to produce artiﬁcial brains that can be grafted onto mobile robotic platforms, with the goal of achieving fully embodied sentient machines
Real-world effectiveness and safety of adalimumab in Korean patients with intestinal Behcet’s disease: a Korean Association for the Study of Intestinal Diseases (KASID) multicenter study

Background/Aims The short- and long-term effects of adalimumab (ADA) on Korean patients with intestinal Behcet’s disease (BD) for remain unclear. Therefore, a multicenter study was performed to evaluate the efficacy and safety of ADA in Korean patients with intestinal BD in a real-world setting. Methods The medical records of 67 patients with BD prescribed ADA between January 2012 and December 2020 at five referral centers in Korea were retrospectively analyzed and the safety and efficacy of ADA within 52 weeks were assessed. To evaluate the clinical efficacy of ADA, the Disease Activity Index for Intestinal BD (DAIBD) and representative blood biochemical markers were compared at 0, 12, 24, and 52 weeks of ADA treatment. Results During the follow-up period of 52 weeks, 46 patients continued ADA treatment. The cumulative drug survival rate was 83.5%. The DAIBD score decreased over the study period (p < 0.001). Moreover, the erythrocyte sedimentation rate, serum C-reactive protein levels, and serum albumin levels significantly improved at 12, 24, and 52 weeks of ADA treatment (all, p <0.05). Conclusions As ADA is effective for refractory intestinal BD with few safety concerns in real-world situations, it is a potential treatment option for Korean patients with intestinal BD.
Lowering Expectations: Glucocorticoid Tapering Among Veterans With Rheumatoid Arthritis Achieving Low Disease Activity on Stable Biologic Therapy

In the Steroid EliMination In Rheumatoid Arthritis (SEMIRA) trial, 65% of patients with rheumatoid arthritis (RA) in low disease activity (LDA) on stable biologic therapy successfully tapered glucocorticoids. We aimed to evaluate real‐world rates of glucocorticoid tapering among similar patients in the Veterans Affairs Rheumatoid Arthritis registry.
Time course of attentional bias and its relationship with PTSD symptoms in bereaved Chinese parents who have lost their only child

ABSTRACT Background: The death of a child is a highly traumatic event for parents and often leads to posttraumatic stress disorder (PTSD). Attentional bias has been demonstrated in the onset and maintenance of PTSD symptoms. Objective: This study aimed to investigate the time course of attentional bias among bereaved Chinese parents who have lost their only child (Shidu parents), and to examine its relationship with PTSD symptoms and symptom clusters. Methods: Shidu parents (n = 38; 50–72 years of age) completed a dot-probe task with negative (trauma-related), positive, and neutral images at four stimulus presentation times (250, 500, 750, and 1250 ms). PTSD symptoms were measured by the PTSD Checklist for DSM-5 (PCL-5). Results: We observed difficulty in disengaging from both negative and positive stimuli at 750 ms and attentional bias away from negative stimuli at 1250 ms. At 1250 ms, attentional avoidance of trauma-related stimuli was positively correlated with PCL-5 total and intrusion scores. Difficulty in disengaging from positive stimuli was negatively correlated with PCL-5 total and intrusion scores as well as negative alterations in cogniti and mood scores. Conclusions: These findings enhance our understanding of attentional bias and cognitive–affective processing in PTSD. This study provides evidence that attentional bias (difficulty in disengaging from positive stimuli and bias away from negative stimuli) are correlated with PTSD symptoms and certain symptom clusters. HIGHLIGHTS The current study examined the time course of attentional bias among bereaved Chinese parents who have lost their only child through a dot-probe task and investigated its relationship with PTSD symptoms and symptom clusters. Participants exhibited difficulty in disengaging from both trauma-related and positive stimuli at 750 ms and exhibited attentional avoidance of trauma-related stimuli at 1250 ms. Attentional avoidance of trauma-related stimuli was positively correlated with PCL-5 total and intrusion scores. Difficulty in disengaging from positive stimuli was negatively correlated with PCL-5 total and intrusion scores as well as negative alterations in cognition and mood scores.
MANAGEMENT OF PERIPARTUM DEPRESSION: BETTER, PREVENT THAN TREAT!.

Suresh Kumar 1 and Laxminarayana Kurady Bairy 2 . 1. Assistant Professor, Department of Pharmacology, RAK College of Medical Sciences, RAK Medical and Health Sciences University, P.O. Box No.11172, Ras Al Khaimah, UAE. 2. Professor and Chairperson, Department of Pharmacology, RAK College of Medical Sciences, RAK Medical and Health Sciences University, P.O. Box No.11172, Ras Al Khaimah, UAE. Manuscript Info Abstract . Manuscript History
Advance in the pharmacological effects of quercetin in modulating oxidative stress and inflammation related disorders

Numerous pharmacological effects of quercetin have been illustrated, including antiinflammation, antioxidation, and anticancer properties. In recent years, the antioxidant activity of quercetin has been extensively reported, in particular, its impacts on glutathione, enzyme activity, signaling transduction pathways, and reactive oxygen species (ROS). Quercetin has also been demonstrated to exert a striking antiinflammatory effect mainly by inhibiting the production of cytokines, reducing the expression of cyclooxygenase and lipoxygenase, and preserving the integrity of mast cells. By regulating oxidative stress and inflammation, which are regarded as two critical processes involved in the defense and regular physiological operation of biological systems, quercetin has been validated to be effective in treating a variety of disorders. Symptoms of these reactions have been linked to degenerative processes and metabolic disorders, including metabolic syndrome, cardiovascular, neurodegeneration, cancer, and nonalcoholic fatty liver disease. Despite that evidence demonstrates that antioxidants are employed to prevent excessive oxidative and inflammatory processes, there are still concerns regarding the expense, accessibility, and side effects of agents. Notably, natural products, especially those derived from plants, are widely accessible, affordable, and generally safe. In this review, the antioxidant and antiinflammatory abilities of the active ingredient quercetin and its application in oxidative stress‐related disorders have been outlined in detail.
Optimal cache placement for an academic backbone network

Deploying caches on a network is an eﬀective way to reduce the amount of data transmitted in a network. Recently, in an academic backbone network such as SINET (the Science Information Network) in Japan, the amount of transmitted data has signi(cid:12)cantly increased. It is desired to design an eﬃcient mechanism to allocate caches in an optimal way. In this paper, we begin by formulating a discrete optimization model to (cid:12)nd a cache allocation that minimizes the total transmission cost. We then design two eﬃcient algorithms to solve our proposed model. The (cid:12)rst one makes use of the fact that a backbone network has small treewidth. The algorithm runs in polynomial time when the number of items is (cid:12)xed and a graph has a bounded treewidth. The other one reduces the problem to the minimum-cost (cid:13)ow problem under the practical assumption that each item has at most one copy. This yields a polynomial-time combinatorial algorithm. Our numerical experiments on the real SINET network show that our algorithms can solve the cache placement problem eﬃciently in practice.
Developmental Feeding Stages and Their Impact on Child Feeding Behavior

Objectives: Previous research has shown that critical periods of feeding skills development exist and feeding problems can arise in children due to delays in attaining feeding developmental milestones. This study aims to delineate the transitional process of feeding development in healthy children and children with gastrointestinal diseases (GIDs) and to examine the relationship between feeding milestones and the appearance of later feeding problems. Methods: A cross-sectional case–control study among 711 healthy Greek children and 119 children with GID, aged 2–7 years. Parents completed the Greek version of the Behavioral Pediatrics Feeding Assessment Scale and “self-reported” questionnaires assessing child’s feeding history. Results: Differences in feeding behavior of preschoolers between the 2 groups were found concerning the time of introduction of complementary (pureed), lumpy, and table foods as well as finger feeding and regular cup-drinking. Age-specific milestones as proposed by guidelines were not reached. Late introduction of complementary and lumpy foods (>6 months and >9 months, respectively) as well as finger feeding (>9 months) were predictive of more problematic feeding behaviors later on. Conclusions: The trajectory of feeding development, including less studied feeding milestones, both in healthy children and children with GIDs, indicates that there are discrepancies between current feeding practices and infant feeding guidelines, and a tendency to delay the acquisition of all assessed feeding milestones.
A Prospective Randomized Controlled Pilot Study to Assess the Response and Tolerability of Cold Atmospheric Plasma for Rosacea

Introduction: Rosacea is a common, facial, chronic inflammatory skin disease. Due to its complex pathogenesis, adequate therapy of rosacea can be challenging. An innovative recent therapeutic tool is cold atmospheric plasma (CAP), which is already established in the treatment of chronic wounds and promising in different other skin diseases. Methods: In a split-face pilot study we investigated dielectric-barrier-discharged CAP in erythemato-telangiectatic (ETR) and/or papulopustular rosacea (PPR). CAP treatment was applied on lesional skin of a randomized side once daily (90 s/area) for 6 weeks. The other untreated side served as control. Co-primary endpoints were ≥1 improvement of the Investigator Global Assessment (IGA) score on the treated side compared to control and a decline of the Dermatology Life Quality Index (DLQI) after 6 weeks. Secondary endpoints included inflammatory lesion count (papules and pustules), skin redness intensity and erythema size. Adverse events (AEs) were recorded constantly. Additionally, participants were weekly assessed for symptoms, skin condition, trigger factors, skin care, treatment success, and local tolerance parameters. All p values were calculated using the Wilcoxon signed-rank test. Results: Twelve subjects (ETR, n = 3; ETR and PPR, n = 9) completed the study. DLQI was significantly improved after 6 weeks (p = 0.007). On the CAP-treated side, lesions (p = 0.007) and erythema size (p = 0.041) were significantly reduced compared to the control. IGA (p = 0.2) and skin redness intensity (p = 0.5) did not differ significantly between control and CAP-treated side. No serious AEs occurred and treatment was well tolerated. Conclusion: CAP is a promising new treatment of rosacea, especially for PPR.
The Impact of Physical Therapy After Lumbar Fusion Surgery

Study Design: Retrospective Cohort. Objective: To determine if outcomes varied between patients based on physical therapy (PT) attendance after lumbar fusion surgery. Summary of Background Data: The literature has been mixed regarding the efficacy of postoperative PT to improve disability and back pain, as measured by patient-reported outcome measures. Given the prevalence of PT referrals and lack of high-quality evidence, there is a need for additional studies investigating the efficacy of PT after lumbar fusion surgery to aid in developing robust clinical guidelines. Methods: We retrospectively identified patients receiving lumbar fusion surgery by current procedural terminology codes and separated them into 2 groups based on whether PT was prescribed. Electronic medical records were reviewed for patient and surgical characteristics, PT utilization, and surgical outcomes. Patient-reported outcome measures (PROMs) were identified and compared preoperatively, at 90 days postoperatively and one year postoperatively. Results: The two groups had similar patient characteristics and comorbidities and demonstrated no significant differences between readmission, complication, and revision rates after surgery. Patients that attended PT had significantly more fused levels (1.41 ± 0.64 vs. 1.32 ± 0.54, P=0.027), longer operative durations (234 ± 96.4 vs. 215 ± 86.1 min, P=0.012), and longer postoperative hospital stays (3.35 ± 1.68 vs. 3.00 ± 1.49 days, P=0.004). All groups improved similarly by Oswestry Disability Index, short form-12 physical and mental health subsets, and back and leg pain by Visual Analog Scale at 90-day and 1-year follow-up. Conclusion: Our data suggest that physical therapy does not significantly impact PROMs after lumbar fusion surgery. Given the lack of data suggesting clear benefit of PT after lumbar fusion, surgeons should consider more strict criteria when recommending physical therapy to their patients after lumbar fusion surgery. Level of Evidence: Level—Ⅲ
Protein target highlights in CASP15: Analysis of models by structure providers

We present an in‐depth analysis of selected CASP15 targets, focusing on their biological and functional significance. The authors of the structures identify and discuss key protein features and evaluate how effectively these aspects were captured in the submitted predictions. While the overall ability to predict three‐dimensional protein structures continues to impress, reproducing uncommon features not previously observed in experimental structures is still a challenge. Furthermore, instances with conformational flexibility and large multimeric complexes highlight the need for novel scoring strategies to better emphasize biologically relevant structural regions. Looking ahead, closer integration of computational and experimental techniques will play a key role in determining the next challenges to be unraveled in the field of structural molecular biology.
Dielectric Losses of Paper in the THz Domain: Literature Review, Needs for Future Research, and Prospective Solutions

High frequency paper‐based electronics is developing fast, with smart yet low cost applications in view. However, the dielectric losses of paper remain a difficult hurdle to overcome. First, the literature on the topic is reviewed and the contributions from moisture, air, mineral filler, and wood constituents to dielectric losses are highlighted. Then, the guidelines for future research are defined, including the need for systematic comparisons in controlled moisture conditions. In an effort to produce low loss materials for paper‐based electronics, it is proposed here to impregnate paper with a low loss substance, after removing residual water.
Fast Iterative Solution of the Time-Harmonic Elastic Wave Equation at Multiple Frequencies

Seismic Full-Waveform Inversion is an imaging technique to better understand the earth's subsurface. Therefore, the reflection intensity of sound waves is measured in a field experiment and is matched with the results from a computer simulation in a least-squares sense. From a computational point-of-view, but also from an economic view point, the efficient numerical solution of the elastic wave equation on current hardware is the main bottleneck of the computations, especially when a large three-dimensional computational domain is considered. In our research, we focused on an alternative problem formulation in frequency-domain. The mathematical challenge then becomes to efficiently solve the time-harmonic elastic wave equation at multiple frequencies. The resulting sequence of shifted linear systems is solved with a new framework of Krylov subspace methods derived for this specific problem formulation. Our numerical analysis gives insight in the theoretical convergence behavior of the new algorithm.
Bound acoustic modes in the radiation continuum in isotropic layered systems without periodic structures

We study the existence of guided acoustic modes in layered structures whose phase velocity is higher than that of bulk waves in a solid substrate or an adjacent ﬂuid half space, which belong to the class of bound states in the radiationcontinuum(BICs). Wedemonstratethatincontrasttotheelectromagneticcase,non-symmetry-protected BICs exist in isotropic layered systems without periodic structures. Two systems supporting non-symmetry-protected sagittally polarized BICs have been identiﬁed: (i) a supported solid layer yields BICs whose phase velocity is higher than the transverse velocity of the substrate but lower than the longitudinal velocity; (ii) a supported solid layer loaded by a ﬂuid half space supports BICs whose velocity is higher that the bulk velocity of the ﬂuid but lower than acoustic velocities of the substrate. The latter case is a unique example of BICs in the sense that it does not involve an evanescent ﬁeld in the ﬂuid half space providing the radiation continuum. In either case, BICs are represented by isolated points in the dispersion relations located within “leaky” branches. We show that these BICs are robust with respect to small perturbations of the system parameters. Numerical results are provided for realistic materials combinations. We also show that no BICs exist in all-ﬂuid layered structures, whereas in solid layered structures there are no shear horizontal BICs and no sagittally polarized BICs whose velocity exceeds the longitudinal velocity of the substrate.