Miracle-dz/UniFAR-FTUs huggingface dataset:
Prognostic Biomarkers in Uveal Melanoma: The Status Quo, Recent Advances and Future Directions

Simple Summary Although rare, uveal melanoma (UM) is the most common cancer that develops inside adult eyes. The prognosis is poor, since 50% of patients will develop lethal metastases in the first decade, especially to the liver. Once metastases are detected, life expectancy is limited, given that the available treatments are mostly unsuccessful. Thus, there is a need to find methods that can accurately predict UM prognosis and also effective therapeutic strategies to treat this cancer. In this manuscript, we initially compile the current knowledge on epidemiological, clinical, pathological and molecular features of UM. Then, we cover the most relevant prognostic factors currently used for the evaluation and follow-up of UM patients. Afterwards, we highlight emerging molecular markers in UM published over the last three years. Finally, we discuss the problems preventing meaningful advances in the treatment and prognostication of UM patients, as well as forecast new roadblocks and paths of UM-related research. Abstract Uveal melanoma (UM) is the most common malignant intraocular tumour in the adult population. It is a rare cancer with an incidence of nearly five cases per million inhabitants per year, which develops from the uncontrolled proliferation of melanocytes in the choroid (≈90%), ciliary body (≈6%) or iris (≈4%). Patients initially present either with symptoms like blurred vision or photopsia, or without symptoms, with the tumour being detected in routine eye exams. Over the course of the disease, metastases, which are initially dormant, develop in nearly 50% of patients, preferentially in the liver. Despite decades of intensive research, the only approach proven to mildly control disease spread are early treatments directed to ablate liver metastases, such as surgical excision or chemoembolization. However, most patients have a limited life expectancy once metastases are detected, since there are limited therapeutic approaches for the metastatic disease, including immunotherapy, which unlike in cutaneous melanoma, has been mostly ineffective for UM patients. Therefore, in order to offer the best care possible to these patients, there is an urgent need to find robust models that can accurately predict the prognosis of UM, as well as therapeutic strategies that effectively block and/or limit the spread of the metastatic disease. Here, we initially summarized the current knowledge about UM by compiling the most relevant epidemiological, clinical, pathological and molecular data. Then, we revisited the most important prognostic factors currently used for the evaluation and follow-up of primary UM cases. Afterwards, we addressed emerging prognostic biomarkers in UM, by comprehensively reviewing gene signatures, immunohistochemistry-based markers and proteomic markers resulting from research studies conducted over the past three years. Finally, we discussed the current hurdles in the field and anticipated the future challenges and novel avenues of research in UM.
Ethical environment, accountability, and sustainability reporting: What is the connection in the hospitality and tourism industry?

Drawing on institutional theory, this study tests how the ethical behaviors of firms, in interaction with public officials and through the strength of accountability regulations, influence sustainability reporting practices in the hospitality and tourism (H&T) sector. The results indicate that firms operating in a highly ethical business environment are less likely than those in a less ethical environment to disclose a sustainability report. However, accountability yields the opposite result; firms established in environments characterized by high accountability are more likely than low accountability environments to issue a sustainability report, which implies a complementary effect between the strength of the accountability and the firms’ sustainability disclosures. This verifies that the weakness or strength of informal and formal institutional forces exert considerable influence on firms’ desire to carry out sustainability reporting. However, this influence is not true of the acquisition of external assurance statements and following Global Reporting Initiative guidelines, with which accountability has a negative and insignificant association, respectively.
Cognitive Impairement in Non-Cirrhotic Portal Hypertension: Highlights on Physiopathology, Diagnosis and Management

Hepatic encephalopathy (HE) is one of the most frequent complications of cirrhosis. Several studies and case reports have shown that cognitive impairment may also be a tangible complication of portal hypertension secondary to chronic portal vein thrombosis and to porto-sinusoidal vascular disease (PSVD). In these conditions, representing the main causes of non-cirrhotic portal hypertension (NCPH) in the Western world, both overt and minimal/covert HE occurs in a non-neglectable proportion of patients, even lower than in cirrhosis, and it is mainly sustained by the presence of large porto-systemic shunt. In these patients, the liver function is usually preserved or only mildly altered, and the development of porto-systemic shunt is either spontaneous or iatrogenically frequent; HE is an example of type-B HE. To date, in the absence of strong evidence and large cooperative studies, for the diagnosis and the management of HE in NCPH, the same approach used for HE occurring in cirrhosis is applied. The aim of this paper is to provide an overview of type B hepatic encephalopathy, focusing on its pathophysiology, diagnostic tools and management in patients affected by porto-sinusoidal vascular disease and chronic portal vein thrombosis.
Distinct cDC subsets co-operate in CD40 agonist response while suppressive microenvironments and lack of antigens subvert efficacy

Agonistic αCD40 therapy has shown to inhibit cancer progression, but only in a fraction of patients. Hence, understanding the cancer cell-intrinsic and microenvironmental determinants of αCD40 therapy response is crucial to identify responsive patient populations and design efficient combination treatments. Here, we showed that the therapeutic efficacy of αCD40 in responder melanoma tumours, relied on pre-existing cDC1-primed CD8+ T cells, however cDC1s were dispensable after αCD40 administration. Surprisingly, in response to αCD40 the abundance of activated cDCs, potentially derived from cDC2s increased, thereby further activating antitumour CD8+ T cells. Hence, distinct cDC subsets are required to induce αCD40 responses. By contrast, lung tumours, characterised by a high abundance of macrophages, were resistant to αCD40 therapy. Combining αCD40 therapy with macrophage depletion led to tumour growth inhibition only in the presence of strong neoantigens. Accordingly, treatment with immunogenic cell-death inducing chemotherapy sensitised non-immunogenic tumours to αCD40 therapy.
Ergonomic and Safety Experiences of Outdoor Gym Equipment Users

The number of outdoor gym equipment (OGE) installed in parks has increased to encourage physical activity and social interactions among city dwellers. However, little is known about perceptions of and experiences with OGE ergonomics and safety. Therefore, this study aims to reveal people’s ergonomic and safety experiences and perceptions about OGE. While the research universe consisted of individuals doing physical exercises in parks with OGE in Sakarya city, the sample was composed of a total of 359 people, 215 males and 144 females, selected using the convenience sampling method. The results showed that although the main purpose of the park-goers is not to use OGE, most of the participants thought that OGE use is not safe. Participants also reported that they had experienced various injuries while using OGE. Overall, although OGE seems to contribute to the healthy living needs of people, the relevant bodies may undertake improvements to increase their ergonomics and safety. In addition, it reveals the necessity of providing necessary trainings for the conscious use of OGE by users and having user quidebooks on OGE. Future research may reveal OGE-oriented behaviors and actual physical activity findings of OGE users. Finally, further research is encouraged to identify the health effects and safety-related issues of OGE.
Tangential forces matter

It is known that radial forces acting in the airgaps of rotating electrical machines on the tips of stator teeth account for a major portion of the vibration of these machines. Despite apparently widespread belief, however, these are not the only significant forces at work. Tangential forces acting on the teeth are invariably many times smaller than their radial counterparts. However, tangential motions of tooth tips are often many times larger than the radial motions in important natural modes of machine vibration. Hence the ability of the tangential tooth-tip forces to excite these modes can be comparable with the radial tooth tip forces. This paper shows that tangential forces acting on the tooth tips should not be neglected in large machines.
Impact of Exercise Modalities on Peripheral and Central Components of Cardiorespiratory Capacity in Heart Transplantation Patients: A Systematic Review and Meta-Analysis

Background and Objectives: To analyze the effects of aerobic, resistance, and combined training on peripheral and central components related to cardiorespiratory capacity after HTx. Materials and Methods: No time restriction was applied for study inclusion. MEDLINE/PubMed; EMBASE, CENTRAL, and PEDro databases were investigated. Studies reporting heart transplanted patients older than 19 years following aerobic, resistance, and combined training according. The outcomes included: V′O2 peak, VE/V’CO2 slope, heart rate (HR peak), systolic and diastolic blood pressure (SBP and DBP peak), maximum repetition test(1RM), sit-to-stand test, and flow-mediated dilation (FMD). The studies were selected by consensus. Four hundred ninety-two studies initially met the selection criteria. Cochrane handbook was used for abstracting data and assessing data quality and validity. Independent extraction by two observers was applied. Results: Isolated aerobic training leads to a greater increase in V′O2 peak than combined training compared to the control group (p < 0.001, I2 = 0%). However, no significant differences were found in the subgroup comparison (p = 0.19, I2 = 42.1%). HR peak increased similarly after aerobic and combined training. High-intensity interval training (HIIT) was better than moderate continuous intensity to increase the V′O2 after long term in HTx. Still, there is scarce evidence of HIIT on muscle strength and FMD. No change on VE/V’CO2 slope, FMD, and SBP, DBP peak. 1RM and the sit-to-stand test increased after resistance training (p < 0.001, I2 = 70%) and CT (p < 0.001, I2 = 0%) when compared to control. Conclusions: Aerobic and combined training effectively improve VO2 peak and muscle strength, respectively. HIIT seems the better choice for cardiorespiratory capacity improvements. More studies are needed to examine the impact of training modalities on VE/V’CO2 slope and FMD.
Modeling Work Space to Schedule Repetitive Floors in Multistory Buildings

Multistory buildings are in a category of projects, termed linear or repetitive projects, that involve considerable repetitive activities performed consecutively by the same crew. Current available network techniques and linear scheduling methods mainly consider technological constraints and resource requirements in the generation of schedules for repetitive work. Such techniques and methods ignore requirements of activities for work space necessary for material storage and movement of manpower and equipment. Ignoring such requirements will increase conflicts among the different trades, decrease productivity, impact safety, and may lengthen project durations. To acknowledge work-space constraints in the scheduling process, one first needs to identify and evaluate the different parameters that characterize work space. Once these parameters are defined, scheduling decisions can be formulated to generate a work sequence based on these parameters. This paper describes a model to define and quantify work-space demand and availability parameters for repetitive floors in multistory buildings. A scheduling procedure to implement these parameters for sequencing repetitive work is discussed. Work continuity issues and variable crew-productivity rates associated with scheduling this type of construction are also considered.
Synthetic Evaluation of Infrasonic Multipole Waveform Inversion

Acoustic source inversions estimate the mass flow rate of volcanic explosions or yield of chemical explosions and provide insight into potential source directionality. However, the limitations of applying these methods to complex sources and their ability to resolve a stable solution have not been investigated in detail. We perform synthetic infrasound waveform inversions that use 3‐D Green’s functions for a variety of idealized and realistic deployment scenarios using both a flat plane and Yasur volcano, Vanuatu as examples. We investigate the ability of various scenarios to retrieve the input source functions and relative amplitudes for monopole and multipole (monopole and dipole) inversions. Infrasound waveform inversions appear to be a robust method to quantify mass flow rates from simple sources (monopole) using deployments of infrasound sensors placed around a source, but care should be taken when analyzing and interpreting results from more complex acoustic sources (multipole) that have significant directional components. In the examples we consider the solution is stable for monopole inversions with a signal‐to‐noise ratio greater than five and the dipole component is small. For most scenarios investigated, the vertical dipole component of the multipole explosion source is poorly constrained and can impact the ability to recover the other source term components. Because multipole inversions are ill‐posed for many deployments, a low residual does not necessarily mean the proper source vector has been recovered. Synthetic studies can help investigate the limitations and place bounds on information that may be missing using monopole and multipole inversions for potentially directional sources.
Effect of plant growth promoting rhizobacteria (PGPR) coated bioformulations on fenugreek

An experiment was conducted under field condition during winter season (Rabi) of 2011-12 on a loamy sand soil at SKN College of Agriculture, Jobner (Rajasthan) to study the effect of bioformulations (PGPR) on growth and yield of fenugreek. There were five treatments,viz. bioformulation FK 14, bioformulation FL 18, bioformulation FK 14 + FL 18, untreated control and local control as check in randomized block design with four replications. The strains in the bioformulations FK 14 and FL 18 were Pseudomonas pituda and Microbacterium taraoxidens, respectively. The bioformulations were applied as seed coating. The study revealed that seed treatment with bioformulation FK 14 + FL 18, being at par with bioformulation FK 14 and FL 18 alone, recorded significantly higher plant height, number of primary branches/plant, number of secondary branches/plant, number of pods/ plant, number of seeds/pod and seed yield (1756.25 kg/ha) over control. The flowering resulted significantly earlier and higher pod length in bioformulation FK 14 + FL 18 as well as FL 18 over the control. The number of days to maturity remained unaffected with different bioformulation. The untreated treatment recorded significantly more number of secondary branches/plant, number of seeds/pod and seed yield over the local control variety whereas, untreated control and local check remained at par for rest of the growth attributes and number of pods/plant and pod length. The per cent yield increase over local check was 11.43, 26.06, 29.98 and 36.43 under control, bioformulation FK 14, FL 18 and FK 14 + FL 18, respectively.
Monopoly Rents in Motorcycle Taxi Services in Bangkok, Thailand

This paper examines the market for motorcycle taxi services in Bangkok, Thailand, in terms of economic rent and the effects of such rent on fares. Three sources of monopoly rent in motorcycle taxi services are identified. Locational rent is attributed to the level of accessibility that is specific to the location of a motorcycle taxi stand. Such locations are limited in terms of accessibility, with few locations that can be substituted with another. The quota rent is arbitrarily created by rent-seeking activities, that is, by setting a quota on the number of operators in each location. Territorial rent is created by restricting the service area for each operator group. Depending on the behavior of the so-called influential people, the monopoly can be either enforced or eroded. A regression analysis of fare data provides evidence that supports the hypothesis of locational and territorial rents. Locational rent decreases as a motorcycle taxi stand is located farther away from a rail transit station. Motorcycle taxi groups with demarcated territories command a fare premium, which may indicate territorial rent. Some stands enjoy a degree of monopoly where there are limited substitute feeder transport modes; stands located near bus stops also command a fare premium because of accessibility. This situation implies that bus services do not compete with motorcycle taxis but provide complementary services. The additional economic rent created by new transit systems is unfairly captured by operator groups and influential people. It is suggested that a competitive market be created for motorcycle taxi services, with value-capture measures that are intended to create a more efficient and fairer feeder transport system.
Uncertainty of Site Amplification Derived from Ground Response Analysis

Site-specific geotechnical ground response analyses (GRAs) are typically performed to evaluate stress and strain demands within soil profiles and/or to improve the estimation of site response relative to generic site terms from empirical prediction equations. Implementation of GRA results in probabilistic seismic hazard analysis (PSHA) requires knowledge of the mean and standard deviation of site amplification from GRA. We provide expressions for evaluating within-event standard deviations of ground motion given the parameterization of site amplification for a particular intensity measure into a nonlinear equation. A key component of those expressions is the standard deviation of site amplification, φlnY. We evaluate from the literature estimates of φlnY from ground response simulations using variable inputs and from interpretations of ground motion recordings. We find data-based studies to exhibit relatively consistent values of φlnY ≈ 0.3 over a wide range of oscillator periods, whereas simulation-based studies produce much higher values below the fundamental period of the analyzed soil column and lower values at longer periods. Values derived from the data-based studies are recommended for application.
Superabsorbent Polymer Seed Coating Reduces Leaching of Fungicide but Does Not Alter Their Effectiveness in Suppressing Pathogen Infestation

Superabsorbent polymers (SAPs) applied to soil have been recognized as water reservoirs that allow plants to cope with periods of drought. Their application as a seed coat makes water available directly to the seeds during their germination and early growth phase, but on the other hand, it can affect the efficiency of plant protection substances used in seed dressing. In our experiments, we evaluated the effect of seed coating with SAP on fungicide leaching and changes in their effectiveness in suppressing Fusarium culmorum infestation. Leaching of fungicide from wheat seeds coated with SAP after fungicide dressing, as measured by the inhibition test of mycelium growth under in vitro conditions, was reduced by 14.2–15.8% compared to seeds without SAP coating. Germination of maize seeds and growth of juvenile plants in artificially infected soil did not differ significantly between seeds dressed with fungicide alone and seeds treated with SAP and fungicide. In addition, plants from the seeds coated with SAP alone grew significantly better compared to untreated seeds. Real-time PCR also confirmed this trend by measuring the amount of pathogen DNA in plant tissue. Winter wheat was less tolerant to F. culmorum infection and without fungicide dressing, the seeds were unable to germinate under strong pathogen attack. In the case of milder infection, similar results were observed as in the case of maize seeds.
Consumers Attitudes towards Internet and Brick and Mortar Store Channels Switching Behavior

The purpose of this study is to examine the role of consumers’ behavioral attitude and intention toward channel switching behavior in regards to Internet and brick and mortar store channels in Malaysia. The survey instrument administered to the Malaysian consumers from regions of Klang Valley and Penang. A total of 497 completed surveys were obtained. Partial least squares (PLS) based structural equation modeling (SEM) technique was used to analyze data. A total of 497 completed surveys were obtained. Findings showed that compatibility and complexity were significant in predicting attitude in regard to switching channel from Internet to brick and mortar store. Relative advantage and compatibility were relevant in predicting attitude in brick and mortar store channel. Attitude also significantly affected channel switching intention regarding to both channels. Our findings reveal that gender and intention significantly affect channel switching behavior.
Recursive simulation models of the semiconductor laser modulation characteristics for accurate performance evaluation of coherent optical CPFSK systems

Modeling of the semiconductor laser nonuniform FM response and residual IM modulation is essential for the computer-aided design of coherent optical communication systems. This paper presents an accurate simulation model, in which the FM and IM responses are represented by recursive digital filters derived directly from measurements. A comparison with previous models of the bibliography reveals the advantages of the current approach. The proposed modeling procedure is applied in the case of a single-electrode DFB laser. This DFB model, in combination with a semi-analytical technique for the evaluation of the error probability, is used to study the influence of the modulation characteristics on the performance of a coherent heterodyne CPFSK system with differential receiver operating at 1 Gb/s. Theoretical and experimental results are in excellent agreement.
A Novel Pd-P Nano-Alloy Supported on Functionalized Silica for Catalytic Aerobic Oxidation of Benzyl Alcohol

Catalytic aerobic oxidation of benzyl alcohol (BnOH) to benzaldehyde (PhCHO) over supported noble metal catalysts has grabbed the attention of researchers due to the critical role of PhCHO in numerous industrial syntheses. In the present study, a novel catalyst, Pd-P alloy supported on aminopropyl-functionalized mesoporous silica (NH2-SiO2), was prepared through in situ reduction and characterized by BET-BJH analysis, SEM, TEM, XRD, FTIR, TG-DTA, and XPS. Chemical properties and catalytic performance of Pd-P/NH2-SiO2 were compared with those of Pd° nanoparticles (NPs) deposited on the same support. Over Pd-P/NH2-SiO2, the BnOH conversion to PhCHO was much higher than over Pd°/NH2-SiO2, and significantly influenced by the nature of solvent, reaching 57% in toluene at 111 °C, with 63% selectivity. Using pure oxygen as an oxidant in the same conditions, the BnOH conversion increased up to 78%, with 66% selectivity. The role of phosphorous in improving the activity may consist of the strong interaction with Pd that favours metal dispersion and lowers Pd electron density.