Miracle-dz/UniFAR-FTUs huggingface dataset:
Efficient Multi-Scale Stereo-Matching Network Using Adaptive Cost Volume Filtering

While recent deep learning-based stereo-matching networks have shown outstanding advances, there are still some unsolved challenges. First, most state-of-the-art stereo models employ 3D convolutions for 4D cost volume aggregation, which limit the deployment of networks for resource-limited mobile environments owing to heavy consumption of computation and memory. Although there are some efficient networks, most of them still require a heavy computational cost to incorporate them to mobile computing devices in real-time. Second, most stereo networks indirectly supervise cost volumes through disparity regression loss by using the softargmax function. This causes problems in ambiguous regions, such as the boundaries of objects, because there are many possibilities for unreasonable cost distributions which result in overfitting problem. A few works deal with this problem by generating artificial cost distribution using only the ground truth disparity value that is insufficient to fully regularize the cost volume. To address these problems, we first propose an efficient multi-scale sequential feature fusion network (MSFFNet). Specifically, we connect multi-scale SFF modules in parallel with a cross-scale fusion function to generate a set of cost volumes with different scales. These cost volumes are then effectively combined using the proposed interlaced concatenation method. Second, we propose an adaptive cost-volume-filtering (ACVF) loss function that directly supervises our estimated cost volume. The proposed ACVF loss directly adds constraints to the cost volume using the probability distribution generated from the ground truth disparity map and that estimated from the teacher network which achieves higher accuracy. Results of several experiments using representative datasets for stereo matching show that our proposed method is more efficient than previous methods. Our network architecture consumes fewer parameters and generates reasonable disparity maps with faster speed compared with the existing state-of-the art stereo models. Concretely, our network achieves 1.01 EPE with runtime of 42 ms, 2.92 M parameters, and 97.96 G FLOPs on the Scene Flow test set. Compared with PSMNet, our method is 89% faster and 7% more accurate with 45% fewer parameters.
Curaxin CBL0137 has the potential to reverse HIV‐1 latency

A cure for human immunodeficiency virus type‐1 (HIV‐1) has been hampered by the limitation of current combination antiretroviral therapy (cART) to address the latent reservoirs in HIV‐1 patients. One strategy proposed to eradicate these reservoirs is the “shock and kill” approach, where latency‐reversing agents (LRAs) are used to reactivate and promote viral cell death and/or immune killing of reactivated cells. Here, we report that curaxin CBL0137, an antitumor compound, can potentiate tumor necrosis factor‐α‐mediated reactivation of latently infected HIV‐1cell lines. Additionally, the single use of CBL0137 is sufficient to reactivate HIV‐1 latent reservoirs in peripheral mononuclear cells (PBMCs) isolated from HIV‐1 positive, cART‐treated, aviremic patients. Thus, CBL0137 possesses capabilities as a LRA and could be considered for the “shock and kill” approach.
The Analgesic Effect of Venlafaxine and Its Mechanism on Oxaliplatin-Induced Neuropathic Pain in Mice

The analgesic effect of venlafaxine (VLX), which is a selective serotonin and noradrenaline reuptake inhibitor (SNRI), has been observed on oxaliplatin-induced neuropathic pain in mice. Significant allodynia was shown after oxaliplatin treatment (6 mg/kg, i.p.); acetone and von Frey hair tests were used to assess cold and mechanical allodynia, respectively. Intraperitoneal administration of VLX at 40 and 60 mg/kg, but not 10 mg/kg, significantly alleviated these allodynia. Noradrenaline depletion by pretreatment of N-(2-Chloroethyl)-N-ethyl-2-bromobenzylamine (DSP-4, 50 mg/kg, i.p.) blocked the relieving effect of VLX (40 mg/kg, i.p.) on cold and mechanical allodynia. However, serotonin depletion by three consecutive pretreatments of para-chlorophenylalanine (PCPA, 150 mg/kg/day, i.p.) only blocked the effect of VLX on mechanical allodynia. In cold allodynia, the α2-adrenergic antagonist idazoxan (10 μg, i.t.), but not the α1-adrenergic antagonist prazosin (10 μg, i.t.), abolished VLX-induced analgesia. Furthermore, idazoxan and 5-HT3 receptor antagonist bemesetron (MDL-72222, 15 μg, i.t.), but not prazosin or mixed 5-HT1, 2 receptor antagonist methysergide (10 μg, i.t.), abolished VLX-induced analgesia in mechanical allodynia. In conclusion, 40 mg/kg of VLX treatment has a potent relieving effect against oxaliplatin-induced neuropathic pain, and α2-adrenergic receptor, and both α2-adrenergic and 5-HT3 receptors are involved in this effect of VLX on cold and mechanical allodynia, respectively.
Cross-validation of three Advanced Clinical Solutions performance validity tests: Examining combinations of measures to maximize classification of invalid performance

Abstract Use of multiple performance validity tests (PVTs) may best identify invalid performance, though few studies have examined the utility and accuracy of combining PVTs. This study examined the following PVTs in the Advanced Clinical Solutions (ACS) package to determine their utility alone and in concert: Word Choice Test (WCT), Reliable Digit Span (RDS), and Logical Memory Recognition (LMR). Ninety-three veterans participated in clinical neuropsychological evaluations to determine presence of cognitive impairment; 25% of the performances were deemed invalid via criterion PVTs. Classification accuracy of the ACS measures was assessed via receiver operating characteristic curves, while logistic regressions determined utility of combining these PVTs. The WCT demonstrated superior classification accuracy compared to the two embedded measures of the ACS, even in veterans with cognitive impairment. The two embedded measures (even when used in concert) exhibited inadequate classification accuracy. A combined model with all three ACS PVTs similarly demonstrated little benefit of the embedded indicators over the WCT alone. Results suggest the ACS WCT has utility for detecting invalid performance in a clinical sample with likely cognitive impairment, though the embedded ACS measures (RDS and LMR) may have limited incremental utility, particularly in individuals with cognitive impairment.
Croceicoccus ponticola sp. nov., a lipolytic bacterium isolated from seawater.

A lipolytic, Gram-stain-negative, aerobic, non-motile and coccoid, ovoid or rod-shaped bacterial strain, designated GM-16T, was isolated from seawater around Pohang in the Republic of Korea. Strain GM-16T grew optimally at 30 °C and in the presence of 1.0-2.0 % (w/v) NaCl. The neighbour-joining phylogenetic tree of 16S rRNA gene sequences showed that strain GM-16T fell within the clade comprising the type strains of Croceicoccus species. Strain GM-16T exhibited the highest 16S rRNA gene sequence similarity (97.7 %) to the type strain of Croceicoccus pelagius and sequence similarities of 96.3-96.7 % to the type strains of the other Croceicoccus species. Strain GM-16T contained Q-10 as the predominant ubiquinone and C18 : 1ω7c and summed feature 3 (C16 : 1ω7c and/or C16 : 1ω6c) as major fatty acids. The major polar lipids of strain GM-16T were phosphatidylcholine, phosphatidylethanolamine, phosphatidylglycerol, sphingoglycolipid and one unidentified glycolipid. The DNA G+C content of strain GM-16T was 62.6 mol%. The mean DNA-DNA relatedness value between strain GM-16T and C. pelagius DSM 101479T was 16 %. The average nucleotide identity values between strain GM-16T and the type strains of C.roceicoccus pelagius, C.roceicoccus marinus, C.roceicoccus naphthovorans and C.roceicoccus mobilis were 83.96-84.44 %. The phylogenetic and genetic data and differential phenotypic properties indicated that strain GM-16T is separated from recognized Croceicoccus species. On the basis of the data presented here, strain GM-16T is considered to represent a novel species of the genus Croceicoccus, for which the name Croceicoccus ponticola sp. nov. is proposed. The type strain is GM-16T (=KACC 19611T=KCTC 62423T=NBRC 113192T).
Measles, magic and misidentifications: a defence of the two-factor theory of delusions

ABSTRACT Corlett (Corlett, P. (this issue). Factor one, familiarity and frontal cortex: A challenge to the two-factor theory of delusions. Cognitive Neuropsychiatry) provides a robust critique of the two-factor theory of delusions. The heart of his critique is two challenges he derives from a paper by Tranel and Damasio (Tranel, D., & Damasio, H. (1994). Neuroanatomical correlates of electrodermal skin conductance responses. Psychophysiology, 31(5), 427–438), who illuminate the autonomic responses and brain damage of four patients often cited in support of the two-factor theory of Capgras delusion. I defend the two-factor theory against Corlett’s two key challenges, arguing that his first challenge has been previously addressed, and that his second challenge is overstated. In my view, these challenges do not negate the two-factor account. Nevertheless, two-factor theorists – and computational psychiatrists – should continue to devise and test falsifiable predictions of their respective theories.
Effect of Nanoparticles Surface Charge on the Arabidopsis thaliana (L.) Roots Development and Their Movement into the Root Cells and Protoplasts

Increasing usage of gold nanoparticles (AuNPs) in different industrial areas inevitably leads to their release into the environment. Thus, living organisms, including plants, may be exposed to a direct contact with nanoparticles (NPs). Despite the growing amount of research on this topic, our knowledge about NPs uptake by plants and their influence on different developmental processes is still insufficient. The first physical barrier for NPs penetration to the plant body is a cell wall which protects cytoplasm from external factors and environmental stresses. The absence of a cell wall may facilitate the internalization of various particles including NPs. Our studies have shown that AuNPs, independently of their surface charge, did not cross the cell wall of Arabidopsis thaliana (L.) roots. However, the research carried out with using light and transmission electron microscope revealed that AuNPs with different surface charge caused diverse changes in the root’s histology and ultrastructure. Therefore, we verified whether this is only the wall which protects cells against particles penetration and for this purpose we used protoplasts culture. It has been shown that plasma membrane (PM) is not a barrier for positively charged (+) AuNPs and negatively charged (−) AuNPs, which passage to the cell.
Variation of Relative Humidity as Seen through Linking Water Vapor to Air Temperature: An Assessment of Interannual Variations in the Near-Surface Atmosphere

It has generally been regarded that, in the warming climate, atmospheric water vapor may increase due to the enhancement in surface evaporation, which is expected from the Clausius–Clapeyron (C–C) equation, along with the assumption that relative humidity experiences small changes. If the variation in relative humidity is small, the response of water vapor to temperature will be closely in line with the C–C equation. However, whether relative humidity experiences large or small changes needs be assessed, and the change of relative humidity should be compared with the change in surface–air temperature. In this study, we link surface vapor pressure, which characterizes atmospheric water vapor, to surface-air temperature, and treat both the temperature and relative humidity as influencing factors. A method based on linear regression is applied to compare the interannual variabilities of relative humidity and temperature in the interannual variation in surface vapor pressure. Whether the year-to-year perturbation of relative humidity is important, compared with the perturbation in surface-air temperature, is explored Results show that, at high latitudes of both hemispheres, the variation in vapor pressure is dominated by air temperature, and relative humidity has small positive contributions. Thus, the variation in relative humidity over these regions is comparably small, and the response of water vapor to temperature can well follow the C–C equation. Differently, at mid-low latitudes, especially on land, air temperature plays a negative role in the variation in vapor pressure. Relative humidity offsets the negative contribution and dominates the variation in vapor pressure, suggesting that the variation in the relative humidity over these regions is comparably large. Hence, the response of water vapor to temperature deviate from the C–C equation. Analysis indicates that the different results of the dominance from the two influencing factors are affected by the dual effects of precipitation or wet-air transport over land. Both precipitation and the transport of cold wet air could break the C–C relation between water vapor pressure and temperature.
The MMR Vaccine and Autism.

Autism is a developmental disability that can cause significant social, communication, and behavioral challenges. A report published in 1998, but subsequently retracted by the journal, suggested that measles, mumps, and rubella (MMR) vaccine causes autism. However, autism is a neurodevelopmental condition that has a strong genetic component with genesis before one year of age, when MMR vaccine is typically administered. Several epidemiologic studies have not found an association between MMR vaccination and autism, including a study that found that MMR vaccine was not associated with an increased risk of autism even among high-risk children whose older siblings had autism. Despite strong evidence of its safety, some parents are still hesitant to accept MMR vaccination of their children. Decreasing acceptance of MMR vaccination has led to outbreaks or resurgence of measles. Health-care providers have a vital role in maintaining confidence in vaccination and preventing suffering, disability, and death from measles and other vaccine-preventable diseases. Expected final online publication date for the Annual Review of Virology Volume 6 is September 30, 2019. Please see http://www.annualreviews. org/page/journal/pubdates for revised estimates.
Infant feeding practices and sleep development in pre‐schoolers from the EDEN mother–child cohort

Sleep problems affect 20%–30% of toddlers and preschoolers. Few longitudinal studies focused on the impact of infant feeding practices on sleep. We aimed to study the associations between feeding practices up to 8 months and trajectories of sleep quantity or quality from 2 to 5–6 years. Analyses included 1,028 children from the EDEN mother–child cohort. Data were collected by self‐administered questionnaires. Associations between feeding practices (breastfeeding, complementary feeding, use of thickened infant formula, night feeding) and sleep trajectories (sleep‐onset difficulties, night waking, nighttime in bed) were analysed by multiple logistic regressions. Predominant breastfeeding for more than 4 months was associated with lower risk for belonging to the persistent sleep‐onset difficulties trajectory. Night feeding at 4 months or at 2 years old was associated with higher risk for belonging to the persistent sleep‐onset difficulties trajectory, and night feeding at 8 months was associated with higher risk for night waking and higher risk for short nighttime in bed. Early introduction (< 4 months) to complementary foods (excluding baby cereals) was related to lower risk for short nighttime in bed. Use of baby cereals or thickened infant formula was related neither to sleep quality nor to sleep quantity. In conclusion, infant feeding practices are associated with sleep trajectories in preschoolers, with notably a potential protective role of breastfeeding. Further researches are needed to clarify the mechanisms of these relationships.
Megalithic tombs in western and northern Neolithic Europe were linked to a kindred society

Significance A new phenomenon of constructing distinctive funerary monuments, collectively known as megalithic tombs, emerged around 4500 BCE along the Atlantic façade. The megalithic phenomenon has attracted interest and speculation since medieval times. In particular, the origin, dispersal dynamics, and the role of these constructions within the societies that built them have been debated. We generate genome sequence data from 24 individuals buried in five megaliths and investigate the population history and social dynamics of the groups that buried their dead in megalithic monuments across northwestern Europe in the fourth millennium BCE. Our results show kin relations among the buried individuals and an overrepresentation of males, suggesting that at least some of these funerary monuments were used by patrilineal societies. Paleogenomic and archaeological studies show that Neolithic lifeways spread from the Fertile Crescent into Europe around 9000 BCE, reaching northwestern Europe by 4000 BCE. Starting around 4500 BCE, a new phenomenon of constructing megalithic monuments, particularly for funerary practices, emerged along the Atlantic façade. While it has been suggested that the emergence of megaliths was associated with the territories of farming communities, the origin and social structure of the groups that erected them has remained largely unknown. We generated genome sequence data from human remains, corresponding to 24 individuals from five megalithic burial sites, encompassing the widespread tradition of megalithic construction in northern and western Europe, and analyzed our results in relation to the existing European paleogenomic data. The various individuals buried in megaliths show genetic affinities with local farming groups within their different chronological contexts. Individuals buried in megaliths display (past) admixture with local hunter-gatherers, similar to that seen in other Neolithic individuals in Europe. In relation to the tomb populations, we find significantly more males than females buried in the megaliths of the British Isles. The genetic data show close kin relationships among the individuals buried within the megaliths, and for the Irish megaliths, we found a kin relation between individuals buried in different megaliths. We also see paternal continuity through time, including the same Y-chromosome haplotypes reoccurring. These observations suggest that the investigated funerary monuments were associated with patrilineal kindred groups. Our genomic investigation provides insight into the people associated with this long-standing megalith funerary tradition, including their social dynamics.
Soot Pollution and Pathological Implications

Carbon-based soot, a black particulate material, is produced when fossil fuels burn partially. Soot is seen as an unwelcome byproduct that results from the insufficient combustion of carbon-containing compounds. The environment is affected by the deposition of soot in water, air and soil. These environmental components serves as a means of exposure to man although, the effect of water and soil exposure are poorly studied. This reviewed has also shown that three pathological conditions may occur as a result of soot exposure; they include- respiratory disorder, cardiovascular disease and cancer. Poly aromatic hydrocarbon (PAH) was reported as carcinogenic substance in soot that causes cancer. Direct contact-mediated lung cell failure and immune response involvement that results in cellular proliferation and fibrosis have been proposed as the mechanisms underlying respiratory illness. Inflammation of myocardiac tissues was considered the pathogenesis of cardiovascular disease in soot exposure individuals. Treatment options were based on the mechanism of soot pathology. Based on existing literatures, this review has demonstrated that soot polluted environment can lead to cancer, cardiovascular disease and respiratory disorder.
Remodeling the cancer epigenome: mutations in the SWI/SNF complex offer new therapeutic opportunities

ABSTRACT Introduction: Cancer genome sequencing studies have discovered mutations in members of the SWItch/Sucrose Non-Fermentable (SWI/SNF) chromatin-remodeling complex in nearly 25% of human cancers. The SWI/SNF complex, first discovered in S. cerevisiae, shows strong conservation from yeast to Drosophila to mammals, contains approximately 10–12 subunits and regulates nucleosome positioning through the energy generated by its ATPase subunits. The unexpected finding of frequent mutations in the complex has fueled studies to identify the mechanisms that drive tumor development and the accompanying therapeutic vulnerabilities. Areas covered: In the review, we focus upon the potential roles different SWI/SNF subunit mutations play in human oncogenesis, their common and unique mechanisms of transformation and the potential for translating these mechanisms into targeted therapies for SWI/SNF-mutant tumors. Expert opinion: We currently have limited insights into how mutations in different SWI/SNF subunits drive the development of human tumors. Because the SWI/SNF complex participates in a broad range of normal cellular functions, defining specific oncogenic pathways has proved difficult. In addition, therapeutic options for SWI/SNF-mutant cancers have mainly evolved from high-throughput screens of cell lines with mutations in different subunits. Future studies should follow a more coherent plan to pinpoint common vulnerabilities among these tumors. Trial registration: ClinicalTrials.gov identifier: NCT02601937. Trial registration: ClinicalTrials.gov identifier: NCT02601950. Trial registration: ClinicalTrials.gov identifier: NCT03213665. Trial registration: ClinicalTrials.gov identifier: NCT02059265.
Multi-Exponential Relaxometry Using $\ell_{{1}}$ -Regularized Iterative NNLS (MERLIN) With Application to Myelin Water Fraction Imaging

A new parameter estimation algorithm, MERLIN, is presented for accurate and robust multi-exponential relaxometry using magnetic resonance imaging, a tool that can provide valuable insight into the tissue microstructure of the brain. Multi-exponential relaxometry is used to analyze the myelin water fraction and can help to detect related diseases. However, the underlying problem is ill-conditioned, and as such, is extremely sensitive to noise and measurement imperfections, which can lead to less precise and more biased parameter estimates. MERLIN is a fully automated, multi-voxel approach that incorporates state-of-the-art <inline-formula> <tex-math notation="LaTeX">$\ell _{1}$ </tex-math></inline-formula>-regularization to enforce sparsity and spatial consistency of the estimated distributions. The proposed method is validated in simulations and <italic>in vivo</italic> experiments, using a multi-echo gradient-echo (MEGE) sequence at 3 T. MERLIN is compared to the conventional single-voxel <inline-formula> <tex-math notation="LaTeX">$\ell _{2}$ </tex-math></inline-formula>-regularized NNLS (rNNLS) and a multi-voxel extension with spatial priors (rNNLS + SP), where it consistently showed lower root mean squared errors of up to 70 percent for all parameters of interest in these simulations.