Miracle-dz/UniFAR-FTUs huggingface dataset:
Projections from the five divisions of the orbital cortex to the thalamus in the rat

The orbital cortex (ORB) of the rat consists of five divisions: the medial (MO), ventral (VO), ventrolateral (VLO), lateral (LO), and dorsolateral (DLO) orbital cortices. No previous report has comprehensively examined and compared projections from each division of the ORB to the thalamus. Using the anterograde anatomical tracer, Phaseolus vulgaris leucoagglutinin, we describe the efferent projections from the five divisions of the ORB to the thalamus in the rat. We demonstrated that, with some overlap, each division of the ORB distributed in a distinct (and unique) manner to nuclei of the thalamus. Overall, ORB projected to a relatively restricted number of sites in the thalamus, and strikingly distributed entirely to structures of the medial/midline thalamus, while completely avoiding lateral regions or principal nuclei of the thalamus. The main termination sites in the thalamus were the paratenial nucleus (PT) and nucleus reuniens (RE) of the midline thalamus, the medial (MDm) and central (MDc) divisions of the mediodorsal nucleus, the intermediodorsal nucleus, the central lateral, paracentral, and central medial nuclei of the rostral intralaminar complex and the submedial nucleus (SM). With some exceptions, medial divisions of the ORB (MO, VO) mainly targeted “limbic‐associated” nuclei such as PT, RE, and MDm, whereas lateral division (VLO, LO, DLO) primarily distributed to “sensorimotor‐associated” nuclei including MDc, SM, and the rostral intralaminar complex. As discussed herein, the medial/midline thalamus may represent an important link (or bridge) between the orbital cortex and the hippocampus and between the ORB and medial prefrontal cortex. In summary, the present results demonstrate that each division of the orbital cortex projects in a distinct manner to nuclei of the thalamus which suggests unique functions for each division of the orbital cortex.
The stochastic background of gravitational waves due to the f-mode instability in neutron stars

This paper presents an estimate for the spectral properties of the stochastic background of gravitational waves emitted by a population of hot, young, rapidly rotating neutron stars throughout the Universe undergoing $f$-mode instabilities, formed through either core-collapse supernova explosions or the merger of binary neutron star systems. Their formation rate, from which the gravitational wave event rate is obtained, is deduced from observation-based determinations of the cosmic star formation rate. The gravitational wave emission occurs during the spin-down phase of the $f$-mode instability. For low magnetized neutron stars and assuming 10\% of supernova events lead to $f$-mode unstable neutron stars, the background from supernova-derived neutron stars peaks at $\Omega_{\text{gw}} \sim 10^{-9}$ for the $l=m=2$ $f$-mode, which should be detectable by cross-correlating a pair of second generation interferometers (e.g. Advanced LIGO/Virgo) with an upper estimate for the signal-to-noise ratio of $\approx$ 9.8. The background from supramassive neutron stars formed from binary mergers peaks at $\Omega_{\text{gw}} \sim 10^{-10}$ and should not be detectable, even with third generation interferometers (e.g. Einstein Telescope).
Canine morphometrics as a tool for distinguishing species, sex, and age class in Southern Ocean fur seals

Carcasses resulting from natural mortalities are invaluable for use in scientific studies, provided species, sex, and age class are known. When such data are unavailable, identifying skeletal remains is necessary if one is to use the information contained within samples. Teeth are amongst the best preserved skeletal remains owing to the durability of enamel and dentine. Here, we tested whether external measurements of canines could be used to distinguish two partially sympatric species of Southern Ocean fur seals, the Antarctic Arctocephalus gazella and Sub‐Antarctic A. tropicalis fur seals. We also investigated whether the external measurements of canines could be used to determine the age, sex, as well as island of origin of the animals. Eight morphological variables (crown length, root length, crown width, root width, crown thickness, root thickness, total canine length, and count of external surface annular ridges) were recorded from canines of 340 individuals of known species, sex, and island of origin. The count of external annular ridges provided a good estimate of age, which was confirmed by counting the growth layer groups of sectioned teeth, especially for older animals (> 9 years old). External canine measurements proved useful in distinguishing species, as well as sex within and between species, particularly in adult animals. Species were more difficult to distinguish in females than in males. The islands of origin could only be inferred in male Antarctic fur seals. This study indicates that fur seal teeth of unknown provenance, found either in breeding colonies or as vagrants, provide evidence on species, sex, and age of the animal, which increases the value of associated samples. It further highlights the importance of external measurements of skeletal remains such as canine teeth in separating closely related species.
The Open Cluster NGC 2437 (Messier 46)

The stellar content of the open cluster NGC 2437 (Messier 46) is investigated using moderately deep u∗, g′, and r′ MegaCam images. When compared with solar metallicity isochrones, the (g′,u′ - g′) and (r′,g′ - r′) CMDs are consistent with an age log(tyr) = 8.35 ± 0.15, a distance modulus μ0 = 11.05 ± 0.05, and a color excess E(B - V) = 0.115 ± 0.035. The r′ luminosity function (LF) of main sequence stars in the magnitude range r′ < 17 (i.e., masses ≳0.8 M⊙) has a shape that follows solar neighborhood star counts. However, at fainter magnitudes, the cluster LF is flat, in contrast with what would be expected from solar neighborhood counts. The clustering properties of stars in NGC 2437 are investigated by examining the two-point angular correlation functions of main sequence stars in different brightness ranges. Main sequence stars fainter than r′ = 17 are less centrally concentrated than brighter stars and are found over a larger area of the sky, suggesting that there is a corona of faint main sequence stars around NGC 2437. Based on the flat LF and extended spatial distribution of faint stars, it is concluded that NGC 2437 is actively shedding stars with masses ≲0.8 M⊙.
A systematic review and meta-analysis of growth mindset interventions: For whom, how, and why might such interventions work?

As growth mindset interventions increase in scope and popularity, scientists and policymakers are asking: Are these interventions effective? To answer this question properly, the field needs to understand the meaningful heterogeneity in effects. In the present systematic review and meta-analysis, we focused on two key moderators with adequate data to test: Subsamples expected to benefit most and implementation fidelity. We also specified a process model that can be generative for theory. We included articles published between 2002 (first mindset intervention) through the end of 2020 that reported an effect for a growth mindset intervention, used a randomized design, and featured at least one of the qualifying outcomes. Our search yielded 53 independent samples testing distinct interventions. We reported cumulative effect sizes for multiple outcomes (i.e., mindsets, motivation, behavior, end results), with a focus on three primary end results (i.e., improved academic achievement, mental health, or social functioning). Multilevel metaregression analyses with targeted subsamples and high fidelity for academic achievement yielded, d = 0.14, 95% CI [. 06, . 22]; for mental health, d = 0.32, 95% CI [. 10, . 54]. Results highlighted the extensive variation in effects to be expected from future interventions. Namely, 95% prediction intervals for focal effects ranged from -0.08 to 0.35 for academic achievement and from 0.07 to 0.57 for mental health. The literature is too nascent for moderators for social functioning, but average effects are d = 0.36, 95% CI [. 03, . 68], 95% PI [-. 50, 1.22]. We conclude with a discussion of heterogeneity and the limitations of meta-analyses. (PsycInfo Database Record (c) 2022 APA, all rights reserved).
Optical circular polarization in quasars

We present new optical circular polarization measurements with typical uncertainties 3σ) circular polarization in two blazars with high linear polarization and discuss the implications of this result for quasar physics. In particular, the recorded polarization degrees may be indicative of magnetic fields as strong as 1 kG or a significant contribution of inverse Compton scattering to the optical continuum.
The elemental composition of the Sun - III. The heavy elements Cu to Th

We re-evaluate the abundances of the elements in the Sun from copper (Z = 29) to thorium (Z = 90). Our results are mostly based on neutral and singly-ionised lines in the solar spectrum. We use the latest 3D hydrodynamic solar model atmosphere, and in a few cases also correct for departures from local thermodynamic equilibrium (LTE) using non-LTE (NLTE) calculations performed in 1D. In order to minimise statistical and systematic uncertainties, we make stringent line selections, employ the highest-quality observational data and carefully assess oscillator strengths, hyperfine constants and isotopic separations available in the literature, for every line included in our analysis. Our results are typically in good agreement with the abundances in the most pristine meteorites, but there are some interesting exceptions. This analysis constitutes both a full exposition and a slight update of the relevant parts of the preliminary results we presented in Asplund et al. (2009, ARA&A, 47, 481), including full line lists and details of all input data that we have employed.
Rapid label-free detection of cholangiocarcinoma from human serum using Raman spectroscopy

Cholangiocarcinoma (CCA) is highly prevalent in the northeastern region of Thailand. Current diagnostic methods for CCA are often expensive, time-consuming, and require medical professionals. Thus, there is a need for a simple and low-cost CCA screening method. This work developed a rapid label-free technique by Raman spectroscopy combined with the multivariate statistical methods of principal component analysis and linear discriminant analysis (PCA-LDA), aiming to analyze and classify between CCA (n = 30) and healthy (n = 30) serum specimens. The model’s classification performance was validated using k-fold cross validation (k = 5). Serum levels of cholesterol (548, 700 cm-1), tryptophan (878 cm-1), and amide III (1248,1265 cm-1) were found to be statistically significantly higher in the CCA patients, whereas serum beta-carotene (1158, 1524 cm-1) levels were significantly lower. The peak heights of these identified Raman marker bands were input into an LDA model, achieving a cross-validated diagnostic sensitivity and specificity of 71.33% and 90.00% in distinguishing the CCA from healthy specimens. The PCA-LDA technique provided a higher cross-validated sensitivity and specificity of 86.67% and 96.67%. To conclude, this work demonstrated the feasibility of using Raman spectroscopy combined with PCA-LDA as a helpful tool for cholangiocarcinoma serum-based screening.
Net overboard: Comparing marine eDNA sampling methodologies at sea to unravel marine biodiversity

Environmental DNA (eDNA) analyses are powerful for describing marine biodiversity but must be optimized for their effective use in routine monitoring. To maximize eDNA detection probabilities of sparsely distributed populations, water samples are usually concentrated from larger volumes and filtered using fine‐pore membranes, often a significant cost–time bottleneck in the workflow. This study aimed to streamline eDNA sampling by investigating plankton net versus bucket sampling, direct versus sequential filtration including self‐preserving filters. Biodiversity was assessed using metabarcoding of the small ribosomal subunit (18S rRNA) and mitochondrial cytochrome c oxidase I (COI) genes. Multispecies detection probabilities were estimated for each workflow using a probabilistic occupancy modelling approach. Significant workflow‐related differences in biodiversity metrics were reported. Highest amplicon sequence variant (ASV) richness was attained by the bucket sampling combined with self‐preserving filters, comprising a large portion of microplankton. Less diversity but more metazoan taxa were captured in the net samples combined with 5 μm pore size filters. Prefiltered 1.2 μm samples yielded few or no unique ASVs. The highest average (~32%) metazoan detection probabilities in the 5 μm pore size net samples confirmed the effectiveness of preconcentration plankton for biodiversity screening. These results contribute to streamlining eDNA sampling protocols for uptake and implementation in marine biodiversity research and surveillance.
Mortality predictors on the day of healthcare-associated Acinetobacter baumanni bacteremia in intensive care unit.

INTRODUCTION Mortality of healthcare-associated Acinetobacter baumannii bacteremia can be 50-60% in intensive care units (ICUs). We aimed to determine the risk factors for 28-day mortality in patients with sepsis due to A. baumannii bacteremia during their ICU follow-up. METHODOLOGY Demographic characteristics, disease severity scores on admission and bacteremia day (BD), resistance status, invasive interventions, and laboratory values showing the infection and severity of the BD, were compared between groups with and without mortality as a retrospective cohort study in the ICU of a tertiary hospital. RESULTS Of a total of 2411 patients, there were 192 cases of bacteremia. After applying the exclusion criteria, 39 patients were recruited for the study, 25 of whom died (mortality rate 64.1%). Higher age, Simplified Acute Physiology Score II (SAPS II) on admission and high Sequential Organ Failure Assessment Score (SOFA), Red Blood Cell Distribution Width (RDW) (p < 0.001), and C-Reactive Protein (CRP) (p = 0.002) on the BD and invasive intervention in follow-up were associated with mortality. When CRP and RDW were both positive, sensitivity was 72%, specificity was 100%, negative predictive value was 33%, and positive predictive value was 100% for the 28-day mortality after BD. Based on multivariate analysis, CRP and RDW values on the BD were independent risk factors for mortality. CONCLUSIONS It is critical to monitor SOFA, RDW, and CRP values in older ICU patients with SAPS II scores and who undergo invasive intervention in follow-up. Increases in these parameters may indicate bacteremia with high mortality due to A. baumannii.
Geo-Storylines: Integrating Maps into Storyline Visualizations

Storyline visualizations are a powerful way to compactly visualize how the relationships between people evolve over time. Real-world relationships often also involve space, for example the cities that two political rivals visited together or alone over the years. By default, Storyline visualizations only show implicitly geospatial co-occurrence between people (drawn as lines), by bringing their lines together. Even the few designs that do explicitly show geographic locations only do so in abstract ways (e.g., annotations) and do not communicate geospatial information, such as the direction or extent of their political campains. We introduce Geo-Storylines, a collection of visualisation designs that integrate geospatial context into Storyline visualizations, using different strategies for compositing time and space. Our contribution is twofold. First, we present the results of a sketching workshop with 11 participants, that we used to derive a design space for integrating maps into Storylines. Second, by analyzing the strengths and weaknesses of the potential designs of the design space in terms of legibility and ability to scale to multiple relationships, we extract the three most promising: Time Glyphs, Coordinated Views, and Map Glyphs. We compare these three techniques first in a controlled study with 18 participants, under five different geospatial tasks and two maps of different complexity. We additionally collected informal feedback about their usefulness from domain experts in data journalism. Our results indicate that, as expected, detailed performance depends on the task. Nevertheless, Coordinated Views remain a highly effective and preferred technique across the board.
A hydrogel–fiber–hydrogel composite scaffold based on silk fibroin with the dual‐delivery of oxygen and quercetin

Supplying sufficient oxygen within the scaffolds is one of the essential hindrances in tissue engineering that can be resolved by oxygen‐generating biomaterials (OGBs). Two main issues related to OGBs are controlling oxygenation and reactive oxygen species (ROS). To address these concerns, we developed a composite scaffold entailing three layers (hydrogel‐electrospun fibers‐hydrogel) with antioxidant and antibacterial properties. The fibers, the middle layer, reinforced the composite structure, enhancing the mechanical strength from 4.27 ± 0.15 to 8.27 ± 0.25 kPa; also, this layer is made of calcium peroxide and silk fibroin (SF) through electrospinning, which enables oxygen delivery. The first and third layers are physical SF hydrogels to control oxygen release, containing quercetin (Q), a nonenzymatic antioxidant. This composite scaffold resulted in almost more than 40 mmHg of oxygen release for at least 13 days, and compared with similar studies is in a high range. Here, Q was used for the first time for an OGB to scavenge the possible ROS. Q delivery not only led to antioxidant activity but also stabilized oxygen release and enhanced cell viability. Based on the given results, this composite scaffold can be introduced as a safe and controllable oxygen supplier, which is promising for tissue engineering applications, particularly for bone.
Wearables, sensors, and smart devices for the detection and monitoring of chemotherapy‐induced peripheral neurotoxicity: Systematic review and directions for future research

Chemotherapy‐induced peripheral neurotoxicity (CIPN) diagnosis is largely based on patient reported outcomes. Wearables, sensors, and smart devices may potentially provide early detection and monitoring of CIPN. We systematically reviewed data on wearables, sensors, and smart devices to detect and/or monitor signs and symptoms of CIPN. Moreover, we provide directions and recommendations for future studies. A literature search using PubMed/MEDLINE, Web of Science, IEEE Xplore, and CINHAL databases was conducted from database inception until March 2021. The search was further updated in July 2022 to ensure currency of results. A total of 1885 records were title‐abstract screened, 33 full texts were assessed, and 16 were included. The retrieved papers were heterogeneous in terms of study design, sample size, CIPN severity, chemotherapy agents, type of wearable/sensor/device applied, parameters of interest, and purpose. Data are promising and provide preliminary evidence on wearables, sensors, and smart devices for CIPN detection and monitoring. There are several issues and knowledge gaps that should be addressed. We propose a framework for future studies.
Phenotypic Correction of Murine Mucopolysaccharidosis Type II by Engraftment of Ex Vivo Lentiviral Vector-Transduced Hematopoietic Stem and Progenitor Cells

Mucopolysaccharidosis type II (MPS II, Hunter syndrome) is an X-linked recessive lysosomal disease caused by deficiency of iduronate-2-sulfatase (IDS). The absence of IDS results in the accumulation of the glycosaminoglycans (GAGs) heparan sulfate and dermatan sulfate. Currently, the only approved treatment option for MPS II is enzyme replacement therapy (ERT), Elaprase. However, ERT is demanding for the patient and does not ameliorate neurological manifestations of the disease. Using an IDS-deficient mouse model that phenocopies the human disease, we evaluated hematopoietic stem and progenitor cells (HSPCs) transduced with a lentiviral vector (LVV) carrying a codon-optimized human IDS coding sequence regulated by a ubiquitous MNDU3 promoter (MNDU3-IDS). Mice treated with MNDU3-IDS LVV-transduced cells showed supraphysiological levels of IDS enzyme activity in plasma, peripheral blood mononuclear cells, and in most analyzed tissues. These enzyme levels were sufficient to normalize GAG storage in analyzed tissues. Importantly, IDS levels in the brains of MNDU3-IDS-engrafted animals were restored to 10–20% than that of wild-type mice, sufficient to normalize GAG content and prevent emergence of cognitive deficit as evaluated by neurobehavioral testing. These results demonstrate the potential effectiveness of ex vivo MNDU3-IDS LVV-transduced HSPCs for treatment of MPS II.
The authors reply

e794 www.ccmjournal. org November 2022 • Volume 50 • Number 11 LWW target limit to be exceeded in case of severe respiratory acidosis (pH < 7.15). A significant advantage of APRV over LTV is that it allows for spontaneous ventilation with patient efforts. Ibarra-Estrada et al (1), in this study, were able to achieve deficient spontaneous minute ventilation (MVspont) in the APRV group (zero up to day 5, first time by day 7). This is in stark contrast to the study by Zhou et al (5) who have achieved it by day 3. Zhou et al (5) also targeted MVspont, approximately 30% total minute ventilation in their study protocol. The low MVspont could be a consequence of using neuromuscular blockade in a large proportion (93%) of patients of APRV group in this study, compared with study by Zhou et al (5) who used it in only 2.8% of patients in APRV group. A second reason could be the absence of any targets for achieving MVspont in the study protocol. Deficient MVspont in APRV group may be one of the reasons why no improvement in ventilator-free days was noted.
Education and Intimate Partner Violence Among Married Women in Nigeria: A Multilevel Analysis of Individual and Community-Level Factors

Research has documented an inverse relationship between lifetime intimate partner violence (IPV) and a woman’s educational accomplishment. Moreover, women without formal education were more likely to report lifetime IPV in comparison with women who completed more than 12 years of education. Therefore, this study examines the individual and community-level factors that determine the degree of IPV vis-à-vis women’s education. Data set of currently married women were extracted from 2018 Nigeria Demographic and Health Survey. The study employed three levels of statistical analysis. The result of the analysis reveals that the nature of IPV differs due to women’s educational status. Women with the highest level of education experienced the least of all the three IPV indicators identified in this study. A significant relationship exists with women’s education and ever experienced physical violence (primary odds ratio [OR] = 1.29; secondary OR = 1.44, higher OR = 0.71). The ORs of ever experienced sexual violence decrease as women’s education increases (secondary OR = 1.10, higher OR = 0.63). The higher significant effect of husband/partner who drinks alcohol on all the three indicators of IPV was affirmed (p < .01). Except for community labor participation, all other community variables were significant with emotional violence and sexual violence (p < .05). The study established that both individual and community factors influence the incidence of IPV in the study area. The study concludes that women empowerment alone cannot reduce the incidence of IPV as revealed in the study; community sensitization about the consequences of IPV on the health of women and the well-being of the family should be intensified.