Miracle-dz/UniFAR-FTUs huggingface dataset:
Just do it: flipped lecture, determinants and debate

This paper describes a case study of two pure mathematicians who flipped their lecture to teach matrix determinants in two large mathematics service courses (one at Stage I and the other at Stage II). The purpose of the study was to transform the passive lecture into an active learning opportunity and to introduce valuable mathematical skills, such as debate, argument and disagreement. The students were told in advance to use the online material to prepare, which had a short handout on matrix determinants posted, as the lesson would be interactive and would rely on them having studied this. At the beginning of the lesson, the two mathematicians worked together to model the skill of professional disagreement, one arguing for the cofactor expansion method and the other for the row reduction method. After voting for their preferred method, the students worked in small groups on examples to defend their choice. Each group elected a spokesperson and a political style debate followed as the students argued the pros and cons of each technique. Although one lecture does not establish whether the flipped lecture model is preferable for student instruction, the paper presents a case study for pursuing this approach and for further research on incorporating this style of teaching in Science, Technology, Engineering and Mathematics subjects.
The Future of Decisions From Experience: Connecting Real-World Decision Problems to Cognitive Processes

In many important real-world decision domains, such as finance, the environment, and health, behavior is strongly influenced by experience. Renewed interest in studying this influence led to important advancements in the understanding of these decisions from experience (DfE) in the last 20 years. Building on this literature, we suggest ways the standard experimental design should be extended to better approach important real-world DfE. These extensions include, for example, introducing more complex choice situations, delaying feedback, and including social interactions. When acting upon experiences in these richer and more complicated environments, extensive cognitive processes go into making a decision. Therefore, we argue for integrating cognitive processes more explicitly into experimental research in DfE. These cognitive processes include attention to and perception of numeric and nonnumeric experiences, the influence of episodic and semantic memory, and the mental models involved in learning processes. Understanding these basic cognitive processes can advance the modeling, understanding and prediction of DfE in the laboratory and in the real world. We highlight the potential of experimental research in DfE for theory integration across the behavioral, decision, and cognitive sciences. Furthermore, this research could lead to new methodology that better informs decision-making and policy interventions.
Tart Cherry Extract and Omega Fatty Acids Reduce Behavioral Deﬁcits and Gliosis in the 5xFAD Mouse Model of Alzheimer’s Disease

: Combined treatments using polyphenols and omega fatty acids provide several therapeutic beneﬁts for a variety of age-related disorders, including Alzheimer’s disease (AD). Previously, we found a commercial product, Total Body Rhythm (TBR), consisting of tart cherry extract, a potent polyphenol, and omega fatty acids, that aims to address the signiﬁcantly reduced memory and neuropathological deﬁcits in the 192 IgG-saporin mouse model of AD. The present study assessed the efﬁcacy of TBR for treating behavioral and neuropathological deﬁcits in the 5xFAD model of AD. Both 6- and 12-month-old 5xFAD mice and age-matched wild-type controls received TBR (60 mg/kg) or the equivalent dose of vehicle (0.5% methylcellulose) via oral administration, every other day for two months. All mice were tested using the open ﬁeld (OF), novel object recognition (NOR), and Morris water maze (MWM) tasks. In addition, neuronal morphology, neurodegeneration, A β plaque load, and glial activation were assessed. TBR treatment reduced memory deﬁcits in the MWM and NOR tests and lessened anxiety levels in the OF task, mostly in the 6-month-old male mice. TBR also protected against neuron loss, reduced activation of astrocytes and microglia, primarily in 6-month-old mice, and attenuated A β deposition. These results suggest that the combination of tart cherry extract and omega fatty acids in TBR can reduce AD-like deﬁcits in 5xFAD mice.
Shared Genetic Contribution to Ischemic Stroke and Alzheimer’s Disease

Objective: Increasing evidence suggests epidemiological and pathological links between Alzheimer’s disease (AD) and ischemic stroke (IS). We investigated the evidence that shared genetic factors underpin the two diseases. Methods: Using genome-wide association study (GWAS) data from METASTROKE 1 (15,916 IS cases and 68,826 controls) and the International Genomics of Alzheimer’s Project (IGAP; 17,008 AD cases and 37,154 controls), we evaluated known associations with AD and IS. On the subset of data for which we could obtain compatible genotype-level data (4,610 IS cases, 1,281 AD cases, and 14,320 controls), we estimated the genome-wide genetic correlation (rG) between AD and IS, and the three subtypes (cardioembolic, small vessel, and large vessel), using genome-wide single-nucleotide polymorphism (SNP) data. We then performed a meta-analysis and pathway analysis in the combined AD and small vessel stroke data sets to identify the SNPs and molecular pathways through which disease risk may be conferred. Results: We found evidence of a shared genetic contribution between AD and small vessel stroke (rG [standard error] 5 0.37 [0.17]; p 5 0.011). Conversely, there was no evidence to support shared genetic factors in AD and IS overall or with the other stroke subtypes. Of the known GWAS associations with IS or AD, none reached significance for association with the other trait (or stroke subtypes). A meta-analysis of AD IGAP and METASTROKE 1 small vessel stroke GWAS data highlighted a region (ATP5H/KCTD2/ICT1) associated with both diseases ( p 5 1.8 3 10 2 8 ). A pathway analysis identified four associated pathways involving cholesterol transport and immune response. Interpretation: Our findings indicate shared genetic susceptibility to AD and small vessel stroke and highlight potential causal pathways and loci.
On Consistent Description of Nuclear Level Density

The back–shifted Fermi gas (BSFG) model has been used for description of the nuclear level density at excitation energies up to the nucleon binding energy by fitting the latest experimental low–lying discrete levels and average s–wave nucleon resonance spacings D0. The analysis of the ratio of the proton and neutron resonance spacings corresponding to the same compound nucleus has led to the ratio IIr=(0.75±0.06) of the effective moment of inertia of the nucleus to the rigid-body value Ir for the nucleus 51V. The energy-dependent level density parameter and the method proposed by Koning and Chadwick for choosing the appropriate shell correction energy have been adopted for energies above the nucleon binding energy. Finally, a consistent description of all experimental data related to the nuclear level density, i.e. the low–lying discrete levels, the nucleon–resonance data, and the level density data above the nucleon binding energy, has been obtained for nuclei within A–ranges 24–41, 55–70, and 104–114.
Antidepressants bind to cholesterol-interaction motif of TRKB neurotrophin receptor

It is unclear how binding of antidepressant drugs to their targets gives rise to the clinical antidepressant effect. We discovered that the transmembrane domain of TRKB, a BDNF receptor promoting neuronal plasticity and antidepressant responses, has a cholesterol-interaction site that may mediate the synaptic effects of cholesterol. We then found that both typical and fast-acting antidepressants bind to this cholesterol-interaction motif, thereby facilitating synaptic localization of TRKB and its activation by BDNF. Docking simulations revealed a binding site at the transmembrane region of TRKB dimers ​ . Mutation of the TRKB cholesterol-interaction motif or cholesterol depletion impaired BDNF-mediated plasticity, as well as cellular and behavioral responses to antidepressants ​ in vitro ​ and ​ in vivo ​ . We suggest that binding to TRKB and the allosteric facilitation of BDNF signaling is the common mechanism for antidepressant action, which proposes a framework for how molecular effects of antidepressants are translated into clinical mood recovery.
Random attractor and stationary measure for stochastic long-short wave equations

Abstract. Asymptotic behaviors of stochastic long-short equations driven by a random force, which is smooth enough in space and white noise in time, are mainly considered. The existence and uniqueness of solutions for stochastic long-short equations are obtained via Galerkin approximation by the stopping time and the Borel-Cantelli Lemma on the basis of a priori estimates in the sense of expectation. A global random attractor and the existence of a stationary measure are investigated by the Birkhoff ergodic theorem and the Chebyshev inequality.
KIER DISCUSSION PAPER SERIES KYOTO INSTITUTE OF ECONOMIC RESEARCH

This study examines the effect of the Covid pandemic containment measures on Japan’s consumption, using high-frequency credit card data. Based on the assumption that neighboring municipalities on prefectural borders with different containment policies have an equivalent fear of contagion, this study distinguishes the negative effect of containment measures on consumption from the effect of fear, by employing a synthetic control method. Specifically, it constructs a synthetic control municipality that faces fear equal to that faced by untreated municipalities in the donor pool, and whose post-treatment consumption corresponds to the counterfactual consumption of the treated municipality without containment intervention. Comparing the synthetic control and treated municipalities’ consumption with prefectural borders, allows the identification of the true impact of the containment policies on consumption. These results indicate that, the negative effects of the state of emergency on consumption is much lower than the extreme decline in consumers’ spending.
Being a Fair Neighbor—Towards a Psychometric Inventory to Assess Fairness-Related Perceptions of Airports by Residents—Development and Validation of the Aircraft Noise-Related Fairness Inventory (fAIR-In)

Aircraft noise causes a variety of negative health consequences, and annoyance is a central factor mediating stress-related health risks. Non-acoustic factors play an important role in the experience of annoyance where the aspect of fairness is assumed to be a vital component. This paper describes the development of the Aircraft Noise-related Fairness Inventory (fAIR-In) and examines its factorial validity, construct validity and predictive validity. The development of the questionnaire included expert consultations, statements from airport residents and a large-scale online survey around three German airports (N = 1367). Its items cover distributive, procedural, informational and interpersonal fairness. Via mailshot, almost 100,000 flyers were sent out in more (>55 dB(A) Lden)- and less (≤55 dB(A) Lden)-aircraft-noise-exposed areas around Cologne-Bonn, Dusseldorf and Dortmund Airport. Thirty-two items were carefully selected considering reliability, theoretical importance and factor loading calculated via exploratory factor analysis (EFA), with all facets achieving high internal consistency (α = 0.89 to 0.92). The factorial validity, analyzed via a confirmatory factor analysis (CFA), revealed that viewing distributive, procedural, informational and interpersonal fairness as distinct factors produced a better fit to the data than other categorizations with fewer factors. The fAIR-In shows adequate results in terms of construct validity and excellent results in terms of the predictive validity of annoyance by aircraft noise (r = −0.53 to r = −0.68), acceptance of airports and air traffic (r = 0.46 to r = 0.59) and willingness to protest (r = −0.28 to r = −0.46). The fAIR-In provides airport managers with a reliable, valid and easy-to-use tool to design, monitor and evaluate efforts to improve the neighborliness between an airport and its residents.
Involvement of Matrix Metalloproteinases in COVID-19: Molecular Targets, Mechanisms, and Insights for Therapeutic Interventions

Simple Summary The costs worldwide of the coronavirus disease 2019 (COVID-19) have been tremendous. With millions of deaths in different countries, understanding biomarkers is essential to diminish the disease burden. For this purpose, a reflective understanding of the pathobiology of COVID-19 is required. During viral infection, some proteins require proteolytic activation and are involved in cell repair and maladaptive organ remodeling. This review summarizes the current findings on the role of increasing matrix metalloproteinases (MMPs) during acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection. COVID-19 patients present distinct complications that can be distinguished by MMP levels. MMPs in excess can generate tissue damage and aggravate the possible complications of COVID-19. MMPs participate in chronic inflammation, and their abnormal regulation is associated with human diseases. Interestingly, individuals with comorbidities or pathological conditions are more susceptible to increasing MMPs and to developing severe COVID-19 illnesses. Furthermore, MMP levels can predict the risk of in-hospital death by COVID-19, suggesting possible prognostic roles. Extensive knowledge of MMPs could provide novel perspectives on the symptoms, pathogenesis, and treatment of COVID-19. Abstract MMPs are enzymes involved in SARS-CoV-2 pathogenesis. Notably, the proteolytic activation of MMPs can occur through angiotensin II, immune cells, cytokines, and pro-oxidant agents. However, comprehensive information regarding the impact of MMPs in the different physiological systems with disease progression is not fully understood. In the current study, we review the recent biological advances in understanding the function of MMPs and examine time-course changes in MMPs during COVID-19. In addition, we explore the interplay between pre-existing comorbidities, disease severity, and MMPs. The reviewed studies showed increases in different MMP classes in the cerebrospinal fluid, lung, myocardium, peripheral blood cells, serum, and plasma in patients with COVID-19 compared to non-infected individuals. Individuals with arthritis, obesity, diabetes, hypertension, autoimmune diseases, and cancer had higher MMP levels when infected. Furthermore, this up-regulation may be associated with disease severity and the hospitalization period. Clarifying the molecular pathways and specific mechanisms that mediate MMP activity is important in developing optimized interventions to improve health and clinical outcomes during COVID-19. Furthermore, better knowledge of MMPs will likely provide possible pharmacological and non-pharmacological interventions. This relevant topic might add new concepts and implications for public health in the near future.
Exploring the Dynamics of Agripreneurship Perception and Intention among the Nigerian Youth

With more than half of young Nigerians either unemployed or underemployed, the problem of youth unemployment poses a serious threat to the social, political, and economic development of the country. Thus, there has been a concerted effort by the government and other stakeholders to address this perennial challenge. Owing to its enormous growth opportunities, agriculture is considered a strategic sector for addressing Nigeria's problem of youth unemployment. However, the lack of youth participation has hampered the growth of the sector. This study investigated the dynamics of agripreneurship perception and intention in order to provide insight to policymakers on how best to develop the agricultural sector and tackle youth unemployment through the engagement of young people in the sector. It also explored agricultural entrepreneurship as a valuable function for young people in Nigeria. A sample of 1,013 recent young graduates took part in this study, which engaged both quantitative and qualitative methodologies. The quantitative analysis was conducted using linear regression and multinomial response models. Additionally, Sen’s capability approach was used as the work’s theoretical framework. The results established that Nigerian youths display a positive perception and intention towards agripreneurship engagement. It also found that participation in entrepreneurship programs, course of study, family income, perceived availability of markets, and infrastructural facilities are determinants of youth’s agripreneurship perception and intention. On the other hand, the study found that the freedom to control one’s time, the expression of one’s passion, and the need to eradicate poverty are reasons young Nigerians value agripreneurship. This study serves as the debut of research endeavours that theoretically evaluate agripreneurship undertakings as valuable functionings using the capability approach. Furthermore, by examining factors that affect agripreneurship perception and intention, the study offers fresh policy insights for youth entrepreneurship and employment creation in the agricultural sector.
Running Head: THE ‘APPEARANCE POTENCY’ OF

With little actual appraisal, a more 'appearance potent' (i.e., a reverence for appearance ideals) subculture has been used to explain gay men's greater body dissatisfaction in comparison to straight men’s. This study sought to assess the respective appearance potency of each subculture by a content analysis of 32 issues of the most read gay ( Attitude , Gay Times ) and straight men's magazines ( Men's Health , FHM ) in the UK. Images of men and women were coded for their physical characteristics, objectification and nudity, as were the number of appearance adverts and articles. The gay men's magazines featured more images of men that were appearance ideal, nude and sexualized than the straight men's magazines. The converse was true for the images of women and appearance adverts. Although more research is needed to understand the effect of this content on the viewer, the findings are consistent with a more appearance potent gay male subculture.
Evaluation of Nurses' Attitudes towards Patients’ End of life in Diyala Governorate

Abstract: Objectives: To assess nurses' attitude toward end of life phase. To find out relationships between nurses attitude and socio demographic data (age, gender, level of education, years of experience). Methodology: A descriptive cross-sectional study design is carried out to assess the attitude on nurses concerning patient at the end of life phase at critical care units, from the period of (1nd November 2021) to (1th February 2022). A probability sample random sampling technique used. Then, the number of participants in Baquba Teaching Hospital and general al khalis hospital were determined by using randomly selected. simple Total of (100) nurses working at critical care units through the time of the study period and the study criteria and agree to participate. Pilot study were excluded ten nurses from the study. the result of co-relation co efficient were (79%). The content validity of the questioner is obtained by panel of (14) experts. inferential statistics and Descriptive were used to analytic the results of the study using the Statistical Package of Social Sciences (SPSS) version 25 and Microsoft Excel (2016). Results: study results of this showed the level of attitude nurse's toward End of life care together with nurses working in diyala city in Iraq were (poor 0%, fair 51%, and good49%). There is no significant difference between nurses’ attitude toward care of the dying patient (number of training course, area of employment). Conclusions: nurses have moderate level of attitude, and there is no significant difference between nurses’ attitude toward care of the dying patient (number of training course, area of employment). Recommendations: The recommended of study is necessity of evolving Education or training that can enhance nurses behavior toward End of life care. investigate relationship amonng religion and spiritual of nurses and their attitude toward end-of-life care.
Socioeconomic Inequalities in Chronic Disease in Kharameh Cohort Study: A Population‐Based Cross‐ Sectional Study in Southern Iran

Background: The trend of chronic diseases is increasing globally. Socioeconomic status (SES) is a major factor underlying many chronic diseases. This study was conducted to investigate the socioeconomic inequalities in distribution of chronic diseases in Iran, as a middle-income country. Methods: This cross-sectional study was conducted using the baseline data of the Kharameh cohort study, that were collected between 2014 and 2016. The number of participants in this study was 10663 people in the age range of 35 to 70 years. Principal component analysis was used for calculating the SES of the people under study. In addition, we used concentration index and concentration curve to measure socioeconomic inequality in chronic disease. Results: The mean age of 10,663 participants in our study was 52.15±8.22 years and the male to female ratio was 1.26. Recurrent headache (25.8%( and hypertension (23.5%) were the most prevalent diseases. The concentration index showed that the distribution of movement disorder, recurrent headaches and gastroesophageal reflux diseases is significantly concentrated among people with low SES, and obesity among people with high SES. The results of the analysis by gender were similar to the results seen in all participants. Conclusion: The findings of this study show that socioeconomic inequality is the cause of the concentration of non-communicable diseases among people with low socio-economic status. Therefore, health policy makers should pay special attention to identifying vulnerable subgroups and formulate strategic plans to reduce inequalities.
Improvement of Organizational Citizenship Behavior (OCB) Assessed From Procedural Trust and Justice

Purpose: The quality of teacher services is an important element related to achieving national education goals and developing Indonesian people as a whole. The initial survey of teacher service quality in the Civil Servants in the High School in the city of Bogor has not yet reached maximum results. Therefore, the quality of teacher services is interesting to study. This study aims to find efforts to improve teacher service quality by examining the relationship of teacher service quality with teacher personality variables and organizational justice. Design/methodology/approach: The study uses correlational statistical methods and analysis of the sitorem method is conducted. The unit of research analysis was a high school civil servant teacher with a population of 279 and a sample of 103 teachers. Findings: Analysis Results there are 9 indicators that the condition is good so it remains to be maintained, namely: (1) sincerity (2) enthusiasm (3) consensus (4) interpersonal justice (5) informational justice (6) distributive justice (7) physical appearance (8) ) guarantee (9) reliability. Components that are the order of priority indicators are improved, namely: (1) stable emotions (2) open to experience (3) procedural fairness (4) responsiveness (5) attention. Research limitations/implications: The results of the study show there is a positive relationship between the teacher's personality and the quality of teacher services with the strength of the relationship ry1 = 0.421 and there is a positive relationship between organizational justice and the quality of the teacher's service with the strength of the ry2 = 0.297 so that the quality of teacher service can be improved through the personality of the teacher and organizational justice. Practical implications: To improve the quality of service teachers can pay attention to indicators that are not optimal for recommendations and determine the order of priority improvements that need to be done. Paper type: Research Paper