Miracle-dz/UniFAR-FTUs huggingface dataset:
ExhaustionInnate Immune Suppression Rather Than Polymicrobial Sepsis Are Characterized by Acute-Phase Deaths from Murine

Sepsis, a leading cause of death in the United States, has poorly understood mechanisms of mortality. To address this, our model of cecal ligation and puncture (CLP) induced sepsis stratiﬁes mice as predicted to Live (Live-P) or Die (Die-P) based on plasma IL-6. Six hours post-CLP, both Live-P and Die-P groups have equivalent peritoneal bacterial colony forming units and recruitment of phagocytes. By 24 h, however, Die-P mice have increased bacterial burden, despite increased neutrophil recruitment, suggesting Die-P phagocytes have impaired bacterial killing. Peritoneal cells were used to study multiple bactericidal processes: bacterial killing, reactive oxygen species (ROS) generation, and phagocytosis. Total phagocytosis and intraphagosomal processes were determined with triple-labeled Escherichia coli, covalently labeled with ROS- and pH-sensitive probes, and an ROS/pH-insensitive probe for normalization. Although similar proportions of Live-P and Die-P phagocytes responded to exogenous stimuli, Die-P phagocytes showed marked deﬁcits in all parameters measured, thus suggesting immunosuppression rather than exhaustion. This contradicts the prevailing sepsis paradigm that acute-phase sepsis deaths (<5 d) result from excessive inﬂammation, whereas chronic-phase deaths (>5 d) are characterized by insufﬁcient inﬂammation and immunosuppression. These data suggest that suppression of cellular innate immunity in sepsis occurs within the ﬁrst 6 h. The Journal of Immunology , 2015, 195: 000–000.
Government Regulation in Technology-Based Innovation Continuance

The emergence of online transportation has triggered the pros and cons. One of the concerns in this matter is the safety issue of taxi-bikes in Southeast Asia. Plenty of studies have analyzed the continuity of services facilitated by an online system, but very limited has conducted a study in a regulated environment. This study will conduct research on the effect of government regulation in public decisions on continuing technology. By having such insight it will help experts and practitioners in understanding the government regulation role on technology continuance. This study used the Technology Continuance Theory basis and added Government Regulation to see the continuity of online taxi-bikes. Data were collected by surveying 454 online taxi-bike users and analyzed using PLS-SEM techniques. The findings indicate that in a developing country, government regulation can directly or indirectly influence the use of online taxi-bikes. Further implications are discussed in the article.
Investigating the Influence of Technostress and Financial Stress Investigating the Influence of Technostress and Financial Stress on Users’ Psychophysiological and Behavioral Responses: A Pilot on Users’ Psychophysiological and Behavioral Responses: A Pilot Study Study

We report on a pilot study investigating the influence of financial stress and technostress on users’ responses towards digital financial transactions. We developed a two-factor within-subject design, where techno-unreliability as variable system response time under time pressure and perceived financial loss were manipulated in a 3x2 design. We collected psychophysiological, perceptual and behavioral data from N=15 participants while performing an adapted version of the Iowa Gambling Task. The analysis reported decreased perception of system responsiveness, financial decision quality, electrodermal activity and variable heart rate in response to both manipulated factors. We posit that these results may indicate participants’ disengagement towards the performance of a transactional digital financial task as a potential coping strategy in response to financial and technological stress. This pilot study contributes to further knowledge towards the understanding of the relationship between technology-related and financial stress.
Do Rating Agencies Behave Defensively for Higher Risk Issuers?

We examine whether rating agencies act defensively toward issuers with a higher likelihood of default. We find that agencies’ qualitative soft rating adjustments are more accurate as issuers’ default risk grows, as evidenced by the adjustments leading to lower type I and type II error rates and better prediction of default and default recovery losses. We also find that soft adjustments’ relevance increases with issuers’ default risk, as evidenced by the adjustments being more predictive of initial offering yields and leading to a greater market reaction to rating changes. Further, we find that the rating agencies assign better educated and more experienced analysts to higher-risk issuers, providing evidence of one mechanism used by the rating agencies to generate more accurate and relevant soft adjustments. Overall, our study suggests that as the likelihood of issuer default grows, the threat of reputational harm from discovered rating failures increasingly mitigates the rating agencies’ strategic behavior incentivized by the issuer-pay model. This paper was accepted by Brian Bushee, accounting.
CCIDE_A_364814 171..182

Aim: To assess oral health-related quality of life (OHRQoL), marginal bone loss (MBL), and changes in soft tissue including probing pocket depth and implant stability in 2 implants retained mandibular overdentures during 5 years follow-up periods. Methods: Forty completely edentulous patients with age 51–64 years were recruited for that longitudinal cohort study. Complete dentures were performed for all participants. Two implants (3.6 × 11.5 mm) were installed in the canine areas of the mandible. OHRQoL and MBL measures were performed every 1 year for 5 years, while clinical measures were made every 6 months for 60 months. Data were examined using repeated ANOVA and Friedman test. Results: Thirty-seven patients had 74 implants; with mean age 56 ± 3.6 years; 43% females (n = 16) and 57% males (n = 21) accomplished the study. There were statistically significant differences in OHRQoL, MBL, and changes in soft tissue, including probing pocket depth and implant stability in 2 implants retained mandibular overdentures during 5 years follow-up periods, p ≤ 0.05. Conclusion: Mandibular overdentures retained by 2 implants provide a positive long-term effect on OHRQoL, MBL, probing pocket depth, and implant stability.
Plastic Hinge Length for Lightly Reinforced C-Shaped Concrete Walls

ABSTRACT This research investigates the equivalent plastic hinge length of reinforced concrete C-shaped walls with reinforcement detailing typically found in low-to-moderate seismic regions. Reinforced concrete walls in these regions commonly have low amounts of longitudinal reinforcement and unconfined boundary regions, which have been shown to perform poorly in recent earthquake events. A series of state-of-the-art finite element analyses are undertaken to find the longitudinal strain distributions of low-rise, mid-rise, and high-rise C-shaped walls. The results of the equivalent plastic hinge lengths from the numerical investigation are shown to compare poorly to the predictions from some of the equations that currently exist in the literature. Subsequently, expressions are derived for the equivalent plastic hinge length for these types of walls and for the different modes of bending. The expressions derived from this research intend to improve the displacement capacity for these types of walls when using plastic hinge analyses.
Historyczne założenia obronne, architectura militaris i LiDAR. Wybrane zagadnienia metodyczne z zakresu zastosowania skanowania laserowego w detekcji i inwentaryzacji nowożytnych fortyfikacji

In recent years, research of defence structures, including modern fortifications, has been advanced by the possibility of verification and documentation of historic structures with the use of aerial laser scanning (ALS). The potential of those state-of-the-art methods is more and more often noticed in literature. Literature focuses so far on permanent fortifi cations and bases on generally known processing methods and visualisations of geodata, such as hill-shading. Thus, worth stressing is the potential and functionalities of ALS for research of field fortifications or destroyed, levelled and barely visible parts of military fortifications. With reference to research methodology, this article stresses the importance and potential not only of spatial analyses and ALS data, but also of their processing methods and of visualisations. The latter two, available in different formats, introduce a new element in the recognition, interpretation and documentation of modern defence structures. A separate aim of this article is to draw attention to growing possibilities of the analysed technology, especially to the so called fourth dimension – registration and analysis of the intensity of reflected laser radiation. The article analyses primarily chosen aspects of methodology connected with research and documentation of modern historic structures, based on laser scanning. It also stresses the efficacy of modern remote sensing technologies for research and protection of heritage, focusing on several important issues connected with the quality of data, their processing, analysis and interpretation and well as on the characteristic environment in which military structures are found – forested areas. Practice and experience acquired so far indicate that after an introductory period of implementing such methods, certain problems connected with the acquisition of data should be pointed out, along with several important research postulates connected with the usage and improvement of hitherto applied research practice. Th e article consists of four main sections: introduction, a section devoted to historic fortifications, technology of laser scanning and different kinds of data processing, and summary. The subject matter is referred to in the light of literature and of own research results, which include analyses of fortifications from the vicinity of Pakoslaw in Mazovia and of the Srebrna Gora Fortress in Lower Silesia. Research work funded by the Ministry of Science and Higher Education under the “National Programme for the Development of Humanities” in 2012–2015.
Jurnal Impresi Indonesia (JII)

Received: 03-05-2022 Introduction: Studies of cross-language perception at the segmental level generally find that adults have great difficulty understanding the contrast of nonnative consonants and/or vowels. Non-original phonotactics are often generated by type accuracy and error. Purpose: This article examines the effect of phonology on non-native phonetic changes. Methods: This research is a qualitative research with a literature review study method from the latest research. The collected data were analyzed by in-depth analysis. Results: Based on the results of data analysis, it shows that non-native speakers are not as accurate in the production of different illegal sequences. These findings also imply that linguistic experiences with native tones need not facilitate non-native phonetic changes. However, non-native phonetics change if there is habituation and construction in the right way. Conclusion: It can be concluded that non-native English still has problems in proper English articulation. Given the importance of phonetic accuracy in expressing spoken messages, foreign speakers must pay close attention to this matter and fix it by encouraging, involving and involving them every time to practice. Accepted: 04-05-2022 Published: 20-05-2022
NDT_A_343747 1145..1149

Introduction: Cariprazine is a third-generation antipsychotic approved in Europe in 2017 for the treatment of schizophrenia. It presents distinct pharmacodynamic properties, such as D3/D2 partial agonism, preferential binding to D3 receptors, antagonism at the serotonin 5-HT2A and 5-HT2B receptors, partial agonism at 5-HT1A receptors, and low affinity to other receptors (including noradrenergic, histaminergic, and cholinergic). It has demonstrated efficacy in the treatment of positive and negative symptoms of schizophrenia with a safe side effect and metabolic profile. Methods: Here, we describe one clinical case of a patient that benefited from an add-on of cariprazine to a regimen of clozapine; and two clinical cases of patients that benefited from the switch from clozapine and paliperidone long-acting injectable to cariprazine. Results and Discussion: Those cases illustrate how cariprazine can be used in patients with schizophrenia in the treatment of both positive and negative symptoms, and when aiming to ameliorate the metabolic burden associated with other treatments. However, further studies are needed to consubstantiate those findings.
Philosophy in the Epoch of Alternative Facts: An Invitation from East Asia

The primary aim of this essay was to elucidate the unique philosophical concept of “the non-interpretive”, which Masaya Chiba, one of the most prominent philosophers in East Asia, formulated mainly by bridging the theories of Quentin Meillassoux and Graham Harman, who have generally been reckoned as two of the most pivotal proponents in the contemporary philosophical movement dubbed Speculative Realism. In order to achieve the aim, the first part clarified the chief arguments and doctrines of Meillassoux’s Speculative Materialism and Harman’s Object-Oriented Philosophy. Thereupon, the second and main part investigated how Chiba invented the concept, what it precisely meant, and what insights it could offer for us. The concluding section summarized the chief arguments of this paper and sketched a worldview which we could adopt in order to survive the turbulent epoch of alternative facts and post-truth.
Shifting Our Awareness, Taking Back Tags: Temporal Changes in Computer Vision Services' Social Behaviors

Much attention has been on the behaviors of computer vision services when describing images of people. Audits have revealed rampant biases that could lead to harm, when services are used by developers and researchers. We focus on temporal auditing, replicating experiments originally conducted three years ago. We document the changes observed over time, relating this to the growing awareness of structural oppression and the need to align technology with social values. While we document some positive changes in the services’ behaviors, such as increased accuracy in the use of gender-related tags overall, we also replicate findings concerning larger error rates for images of Black individuals. In addition, we find cases of increased use of inferential tags (e.g., emotions), which are often sensitive. The analysis underscores the difficulty in following changes in services’ behaviors over time, and the need for more oversight of such services.
Leveraging Online Social Capital: How the German Red Cross Uses Social Networking Sites

Non-governmental organisations (NGOs) that focus on humanitarianism, such as the Red Cross, provide services that make the world a better place. To do so, they are highly dependent on a network that generates goodwill, volunteers, and donations. Social Networking Sites (SNS) are a vital channel for NGOs to pursue their organisational objectives. However, how NGOs utilise SNS to tap into resources for social action is insufficiently understood. In this paper, we investigate how the German Red Cross builds and fosters online social capital via SNS. We conducted semi-structured interviews with five SNS experts from regional units of the German Red Cross and analysed their corresponding Twitter and Facebook profiles. Our findings help identify crucial areas of social capital management via SNS for practitioners in the non-profit sector. Moreover, our research contributes to the conceptualisation of organisational online social capital by classifying SNS constituents with respect to structural, relational, and cognitive dimensions.
Discriminant analysis of growth traits in indigenous, crossbred and exotic turkeys in Nigeria: A review

In rural areas where measuring scales are expensive and unavailable, linear body measurements can be used as predictors of body weight. Breast girth (BG), body length (BL), wing span (WS), wing length (WL), and thigh length (TL) of Nigerian local turkeys are the best discriminating variables in differentiating the birds, according to recent studies. There are also significant physical differences between the sexes, as well as differences in trait associations within each sex. Genetic differences may account for the majority of morphological differences in turkeys. In developing and underdeveloped countries, discriminant analysis provides a practical analytical framework for characterizing and managing turkey's genetic resources. To fully understand the genetic variation among indigenous, crossbred, and exotic turkeys, this study should be followed up with molecular approaches. The ability to distinguish the growth traits of indigenous or native, exotic and crossbred turkeys in Nigeria using multivariate discriminant analysis could aid in the implementation of a conservation and improvement strategy for indigenous turkeys, ensuring the long-term development of animals using their genetic merits. Dans les zones rurales où les échelles de mesure sont chères et indisponibles, les mesures corporelles linéaires peuvent être utilisées comme prédicteurs du poids corporel. La circonférence de la poitrine (CP), la longueur du corps (LC), l'envergure des ailes (EA), la longueur des ailes (LA) et la longueur des cuisses (LC) des dindes locales nigérianes sont les meilleures variables discriminantes pour différencier les oiseaux, selon des études récentes. Il existe également des différences physiques significatives entre les sexes, ainsi que des différences dans les associations de traits au sein de chaque sexe. Les différences génétiques peuvent expliquer la majorité des différences morphologiques chez les dindes. Dans les pays en développement et sous-développés, l'analyse discriminante fournit un cadre analytique pratique pour caractériser et gérer les ressources génétiques de la dinde. Pour bien comprendre la variation génétique parmi les dindes indigènes, croisées et exotiques, cette étude devrait être suivie d'approches moléculaires. La capacité de distinguer les traits de croissance des dindes indigènes ou indigènes, exotiques et croisées au Nigeria à l'aide d'une analyse discriminante multivariée pourrait aider à la mise en œuvre d'une stratégie de conservation et d'amélioration des dindes indigènes, assurant le développement à long terme des animaux en utilisant leurs mérites génétiques.
Moderators of Academic Performance and Symptom Severity in Adolescents with Attention-Deficit/Hyperactivity Disorder

v INTRODUCTION . 1 STUDY 1: ROUTINES AND COMMUNICATION Methods . 15 Results . 20 STUDY 2: SCHOOL ENGAGEMENT AND PARENTAL INVOLVEMENT Methods . 25 Results . 29 DISCUSSION . 37 APPENDIX A. CONSENT FORM . 43 APPENDIX B. DEMOGRAPHIC QUESTIONNAIRE . 45 APPENDIX C. ASSENT FORM . 46 APPENDIX D. ADOLESCENT ROUTINES QUESTIONNAIRE: SELF-REPORT . 47 APPENDIX E. BEHAVIORAL-EMOTIONAL-COGNITIVE SCHOOL ENGAGEMENT SCALE . 48 APPENDIX F. PARENTAL SUPPORT FOR LEARNING: ADOLESCENT FORM . 49 APPENDIX G. IRB APPROVAL . 50 REFERENCES . 51 VITA . 62
Momentum Transfer in Boundary Layers Tuncer Cebeci and Peter Bradshaw Hemisphere Publishing Corpn., Washington DC. 1977. 391 pp. Illustrated. £11.50.

Too many books on fluid mechanics are written on the strength of original material which makes up one chapter or less; the remainder being a restatement of the familiar contents of other books. This book by Cebeci and Bradshaw is totally free from such objections. The authors have both made very substantial contributions to knowledge in the area covered by the book. This shows clearly in the authority of the presentation, in the large number of very recent references and in the material, which is fresh and up-to-date without in any way being self-consciously trendy. Despite its title, the book is concerned with thin shear layers of all kinds and for the most part does not discuss them explicitly in terms of momentum transport: the title is presumably chosen to show that heat and mass transfer effects are not considered. The material covered is an impressive array of cases, representing the present state of knowledge. Far from the conventional concentration on two-dimensional wall boundary layers, the book gives considerable emphasis to both external and internal flows, to axisymmetric and three dimensional configurations and to free shear layers. Modern finite difference methods are described and, where appropriate, listings of Fortran programs are presented. The emphasis is on practical cases and practical methods of solution. A large number of novel and interesting problems and worked examples are given. The reviewer found the exposition uneven: in many parts, every comment carries an exciting new insight but in others the vision seems diminished and the presentation difficult to follow. A few passages consist of the presentation of the first author's research with little or no discussion of other methods. Surprisingly the derivation of the equations makes no mention of matched asymptotic expansions. Indeed, the laminar thin shear layer equations are accorded only the somewhat humble status of a data correlation. However, it would be unfair and misleading to emphasise minor shortcomings. The book is a powerful addition to the literature. It wil l demand an effort from its readers and is likely to be too advanced and uncompromising for undergraduate use but for postgraduate students and research workers, it is very welcome indeed. Any effort it demands is amply repaid. B. L. HUNT
Updated Trends on the Biodiscovery of New Marine Natural Products from Invertebrates

From 1990–2019, a total of 15,442 New Marine Natural Products from Invertebrates (NMNPIs) were reported. The 2010s saw the most prolific decade of biodiscovery, with 5630 NMNPIs recorded. The phyla that contributed most biomolecules were the Porifera (sponges) (47.2%, 2659 NMNPIs) and the Cnidaria (35.3%, 1989 NMNPIs). The prevalence of these two phyla as the main sources of NMNPIs became more pronounced in the 2010s. The tropical areas of the Pacific Ocean yielded more NMNPIs, most likely due to the remarkable biodiversity of coral reefs. The Indo-Burma biodiversity hotspot (BH) was the most relevant area for the biodiscovery of NMNPIs in the 2010s, accounting for nearly one-third (1819 NMNPIs) of the total and surpassing the top BH from the 1990s and the 2000s (the Sea of Japan and the Caribbean Islands, respectively). The Chinese exclusive economic zone (EEZ) alone contributed nearly one-quarter (24.7%) of all NMNPIs recorded during the 2010s, displacing Japan’s leading role from the 1990s and the 2000s. With the biodiscovery of these biomolecules steadily decreasing since 2012, it is uncertain whether this decline has been caused by lower bioprospecting efforts or the potential exhaustion of chemodiversity from traditional marine invertebrate sources.