Miracle-dz/UniFAR-FTUs huggingface dataset:
Toxic Effects of Aflatoxin B1 in Chinese Sea Bass (Lateolabrax maculatus)

This study was performed to assess the effects of dietary aflatoxin B1 (AFB1) on the growth, antioxidant and immune response, digestive enzyme activities, and intestinal morphology of Lateolabrax maculatus during a 56-day feeding trial. Four diets were formulated including 0, 0.1, 0.5, and 1.0 mg/kg of AFB1. Each diet was randomly assigned to 3 fish tanks with 40 fish per tank. Results indicated that the fish’s final body weight, weight gain rate, specific growth rate, feed intake, condition factor, viscerosomatic index, hepatosomatic index, and intestinesomatic index decreased (p < 0.01) as dietary AFB1 increased. AFB1 levels in diets increased (p < 0.05) serum total antioxidant capacity (TAOC), superoxide (SOD), catalase, malondialdehyde (MDA), alkaline phosphatase (AKP), and lysozyme (LZM), and increased (p < 0.05) the TAOC, SOD, MDA, AKP, LZM, and immunoglobulin M in the livers of the fish. Dietary AFB1 decreased (p < 0.05) intestinal trypsin activity and induced intestinal injury. In summary, dietary AFB1 up to 1.0 mg/kg was toxic to L. maculatus as judged by reduced growth, enhanced antioxidant and immune response, decreased intestinal trypsin activity, and impaired intestinal morphology.
Crosstalk between Statins and Cancer Prevention and Therapy: An Update

The importance of statins in cancer has been discussed in many studies. They are known for their anticancer properties against solid tumors of the liver or lung, as well as diffuse cancers, such as multiple myeloma or leukemia. Currently, the most commonly used statins are simvastatin, rosuvastatin and atorvastatin. The anti-tumor activity of statins is largely related to their ability to induce apoptosis by targeting cancer cells with high selectivity. Statins are also involved in the regulation of the histone acetylation level, the disturbance of which can lead to abnormal activity of genes involved in the regulation of proliferation, differentiation and apoptosis. As a result, tumor growth and its invasion may be promoted, which is associated with a poor prognosis. High levels of histone deacetylases are observed in many cancers; therefore, one of the therapeutic strategies is to use their inhibitors. Combining statins with histone deacetylase inhibitors can induce a synergistic anticancer effect.
Characteristics of Medico-Legal Cases and Errors in Medico-Legal Reports at a Teaching Hospital in Saudi Arabia

Introduction A medico-legal case (MLC) involves any injury or medical condition in which law enforcement agencies investigate and fix the responsibility regarding of an injury or medical condition. Incorrect or incomplete medico-legal reports (MLRs) may trigger a pause or delay in legal proceedings and patients’ rights could be violated. The aim of this study is to describe the characteristics of MLCs and to identify errors in the MLRs. Materials and Methods This retrospective, descriptive study was conducted in a teaching hospital in the Eastern Province of Saudi Arabia. In total, 418 MLRs furnished during a 6-month period and reviewed for characteristics of MLCs and identification of errors. Results A total of 418 MLRs were included in the present study. Fights or physical assault and battery formed the major proportion of MLCs amounting to 83% of MLCs. Blunt injury was the dominant type of injury in most of the cases (81.8%). In relation to errors in MLRs, no MLR in the present study were without errors. Conclusion Fights or physical assault and battery formed the major proportion of MLCs. Multiple errors were identified in the MLRs furnished by the physicians. Writing MLRs must follow standardized guidelines as it has a bearing on legal proceedings and patients’ rights. We recommend training for physicians in writing MLRs in the interest of proper administration of justice.
Places of Phygital Shopping Experiences? The New Supply Frontier of Business Improvement Districts in the Digital Age

Business Improvement Districts (BIDs) have flourished as local governance structures to foster the vitality and viability of traditional shopping districts that have struggled to adapt to retail changes. This paper examines the evolution of placemaking activities that former UK government-funded pilot BIDs have delivered over the last 15 years. Drawing on an exploratory sequential research design that combines a qualitative and quantitative thematic analysis of 72 BIDs’ business plans, the findings suggest that UK BIDs have described a non-hierarchical operational framework as services providers considering that: (i) elementary placemaking services, such as ‘clean, green and safe’, have regained thematic relevance due to recent environmental sustainability concerns; (ii) higher-tier lobbying and advocacy services have been an operational priority since BIDs’ inception; (iii) while consumer and place marketing/branding services have seen continual thematic reductions, digital presence and marketing services have emerged as a new category of operational activities. These results extend place management and BID-related literature by discussing the growing role that digital marketing services may perform in the management of town centers and high streets and are relevant to practitioners as it discusses how place management organizations should reposition their operational strategies towards the creation of places of phygital shopping experiences.
An Experimental and Computational Investigation of Flow in a Radial Inlet of an Industrial Pipeline Centrifugal Compressor

The flowfield of a complex three dimensional radial inlet for an industrial pipeline centrifugal compressor has been experimentally determined on a half scale model. Based on the experimental results, inlet guide vanes have been designed to correct pressure and swirl angle distribution deficiencies. The unvaned and vaned inlets are analyzed with a commercially available fully 3D viscous Navier-Stokes code. Since experimental results were available prior to the numerical study, the unvaned analysis is considered a postdiction while the vaned analysis is considered a prediction. The computational results of the unvaned inlet have been compared to the previously obtained experimental results. The experimental method utilized for the unvaned inlet is repeated for the vaned inlet and the data has been used to verify the computational results. The paper will discuss experimental, design and computational procedures, grid generation, boundary conditions, and experimental versus computational methods. Agreement between experimental and computational results is very good, both in prediction and postdiction modes. The results of this investigation indicate that CFD offers a measurable advantage in design, schedule and cost and can be applied to complex, three dimensional radial inlets.Copyright © 1994 by ASME
Correlation between the Flow and Curing Behavior of Hard Magnetic Fillers in Thermosets and the Magnetic Properties

Polymer bonded magnets based on thermoplastics are economically produced by the injection molding process for applications in sensor and drive technology. Especially the lack of orientation in the edge layer, as well as the chemical resistance and the creep behavior limit the possible implementations of thermoplastic based polymer bonded magnets. However, thermoset based polymer bonded magnets have the opportunity to expand the applications by complying with the demands of the chemical industry or pump systems through to improved chemical and thermal resistance, viscosity and creep behavior of thermosets. This paper investigates the influence of hard magnetic particles on the flow and curing behavior of highly filled thermoset compounds based on an epoxy resin. The basic understanding of the behavior of those highly filled hard magnetic thermoset systems is essential for the fabrication of polymer bonded magnets based on thermosets in the injection molding process. It is shown that several factors like the crystal structure, the particle shape and size, as well as the thermal conductivity and the adherence between filler and matrix influence the flow and curing behavior of highly filled thermoset compounds based on epoxy resin. However, these influencing factors can be applied to any filler system with respect to a high filler amount in a thermoset compound, as they are based on the material behavior of particles. Further, the impact of the flow and curing behavior on the magnetic properties of polymer bonded magnets based on thermosets is shown. With that, the correlation between material based factors and magnetic properties within thermosets are portrayed.
Long-term stability and electrical properties of compensation doped poly-Si IC-resistors

The electrical properties and the long-term stability of the resistivity have been studied for polysilicon films heavily doped with phosphorus (P) and adjusted by boron (B) compensation. Phosphorus was found to block the access of hydrogen (H) to the dangling bonds. A theoretical model for the drift in resistivity under electrical and thermal stress showed the number of participating H atoms to be two orders of magnitude smaller than the number of grain-boundary traps. The activation energy for the n-type film was 0.5/spl plusmn/0.1 eV. Whereas the total drift was reduced in the compensated n-type films, the presence of B-P complexes acting as hole traps caused the drift to increase in the p-type films. Hall measurements confirmed the presence of these complexes and showed them to consist of pairs of B and P atoms. The traps followed the U-shaped density of states in their concentration dependence. The trap density was higher in the p-type than in the n-type films due to the B-P hole traps. Compared to the Si dangling bond traps, these traps had a lower activation energy, 0.3/spl plusmn/0.1 eV, and a higher rate constant for the dissociation of the bonds to H. The f-factor for singly n-type films was found to be 0.52.
One size does not fit all: Genetic considerations from the Missouri elk restoration

Population restoration is an inherently costly conservation practice typically reliant on animal translocations. There are many approaches to translocation and consideration is paid to understanding how various translocation models influence restoration success. Translocation strategies are often designed to meet site‐specific objectives, minimize cost, and maximize success. We investigated genetic diversity retention associated with the low‐founder, multi‐release, single admixed stock translocation model of the Missouri elk (Cervus canadensis) restoration in 2011–2013. We further estimated effective population size and projected future losses in genetic diversity if the restored Missouri elk herd is maintained at the population size objective with no immigration from neighboring states. We observed relatively high levels of genetic diversity retention as evidenced by minimal losses in allelic richness and expected heterozygosity. Our projections indicated 90% genetic diversity retention within the Missouri population for roughly 130 years. Where number of progeny or source stocks are limited by resource or disease considerations, use of a relatively low‐founder, single admixed source may enable retention of genetic variation, while minimizing costs.
Performance measures: relating facilities to business indicators

Throughout the 1980s and into the 1990s, manufacturing companies have adopted a wide variety of performance‐improvement programmes. Such approaches have resulted in productivity gains for some companies, although the UK still has few world‐class performers. Despite huge investment in performance‐improvement programmes, competitive advantage for many British companies still remains elusive. Looks at recent developments in thinking which have begun to shed light on why this is happening. Discusses flaws in the widely‐adopted competitive‐forces model and considers the strategic‐capabilities approach as an alternative and potentially crucial model. In the context of the whole organization, it is claimed that the role of facilities management has evolved from merely helping the organization survive, to acting to enhance its potential to prosper in a volatile commercial climate. Thus the challenge for facilities management is indeed the same challenge facing the organization.
Empathy and Defender Role in Bullying at School: Student-Teacher Relationship as Mediator

Introduction. Although much research has shown strong relationship between empathy and defender role, less is known about how student-teacher relationship mediated those variables. Our main hyphotesis was to reveal whether the student-teacher relationship could be mediating the effect of affective and cognitive empathy on the defender role in bullying at school. Method. A total of 311 participants were selected from 2 secondary schools in south Jakarta. Students refer to grade 7-8 with ranged in age from 13 to 15 years (Mage = 13.64; SD = .713). There were four instruments used: The Basic Empathy Scale to measure affective and cognitive empathy, Behaviors During Aggressive Episodes and Student Bystander Behavior Scale to measure defender role, and Student Per- ception of Affective Relationship with Teacher Scale. Results. The results revealed both affective and cognitive empathy were found having a positive effect on defender role in bullying situation among junior high school stu- dents. However, cognitive empathy was found positively stronger on defender role rather than affective empathy. Furthermore, student-teacher relationship only partially mediated the effect both affective and cognitive empathy on defender role. Discussion and Conclusion. These findings emphasized the urgency of comprehensive program to create defender by enhancing empathy and positive student-teacher rela- tionship to inhibit bullying behavior at schools.
Prediction of Different Eye Diseases Based on Fundus Photography via Deep Transfer Learning

With recent advancements in machine learning, especially in deep learning, the prediction of eye diseases based on fundus photography using deep convolutional neural networks (DCNNs) has attracted great attention. However, studies focusing on identifying the right disease among several candidates, which is a better approximation of clinical diagnosis in practice comparing with the case that aims to distinguish one particular eye disease from normal controls, are limited. The performance of existing algorithms for multi-class classification of fundus images is at most mediocre. Moreover, in many studies consisting of different eye diseases, labeled images are quite limited mainly due to privacy concern of patients. In this case, it is infeasible to train huge DCNNs, which usually have millions of parameters. To address these challenges, we propose to utilize a lightweight deep learning architecture called MobileNetV2 and transfer learning to distinguish four common eye diseases, including Glaucoma, Maculopathy, Pathological Myopia, and Retinitis Pigmentosa, from normal controls using a small training data. We also apply a visualization approach to highlight the loci that are most related to the disease labels to make the model more explainable. The highlighted area chosen by the algorithm itself may give some hints for further fundus image studies. Our experimental results show that our system achieves an average accuracy of 96.2%, sensitivity of 90.4%, and specificity of 97.6% on the test data via five independent runs, and outperforms two other deep learning-based algorithms both in terms of accuracy and efficiency.
Sugar Content of Market Beverages and Children’s Sugar Intake from Beverages in Beijing, China

(1) Background: This study aims to find the sugar content of market beverages and estimate the sugar intake from beverages among students in Beijing. (2) Methods: Using snapshotting, we collected the sugar content of beverages through their packages or nutrition labels. Combined with the statistic of student beverage consumption, we estimated students’ sugar intake. (3) Results: The median sugar content of total beverages was 9.0 g/100 mL, among which the fruits/vegetable juices and beverages had the highest sugar content (10.0 g/100 mL). Sugar content in most beverages in Beijing was generally higher than the recommendations, and fruit/vegetable juices and beverages exceeded the most. The median of sugar intake from beverages among students was 5.3 g/d, and the main sources were fruit/vegetable juices and beverages, protein beverages and carbonated beverages. Sugar intake from beverages differed according to gender, age and living area. Higher sugar intake was found among boys, older students and rural students. (4) Conclusions: Sugar content in market beverages in Beijing were high. Gender, age and residence were the influencing factors of sugar intake. Targeted measures should be taken to decrease the sugar content in beverages, especially the fruit/vegetable juices and beverages and the sugar intake among students.
Target-Based Physiological Modulations and Chloroplast Proteome Reveals a Drought Resilient Rootstock in Okra (Abelmoschus esculentus) Genotypes

As climate changes increase, drought stress is becoming a problem for all major horticultural crops; among them is okra (Abelmoschus esculentus). Despite its superior resilience to heat stress and high nutritional content, it is still underutilized in contrast to other vegetable crops. Moreover, the drought-resistant and drought-sensitive genotypes of okra are also not well known and require further exploration to improve their productivity. To investigate this in more detail, we performed comparative physiological and large-scale chloroplast proteomics on drought-stressed genotypes of okra. We evaluated four major genotypes of okra, viz., NS7774, NS7772, Green Gold, and OH3312 for drought resilient rootstock. The physiological modulations demonstrated a significant change by 50–76% in biomass, net-photosynthetic machinery, water transport, and absorption both in early and late stages of drought stress compared to well-watered crops in all genotypes. Maximum oxidative damage due to drought stress was observed for the genotypes NS7772, Green Gold and OH3312 as depicted by H2O2 and O2− determination. Greater oxidative stress was correlated to lesser antioxidant activity and expression of antioxidant enzymes, such as catalase and ascorbate peroxidase under stress in okra genotypes. The overall photosynthetic pigments, such as total chlorophyll, and total carotenoid content, were also decreased, and stomatal guard cells were disrupted and appeared closed compared to the control for the above three mentioned genotypes, except NS7774. A subsequent tissue-specific proteome analysis of chloroplasts and thylakoids analyzed by BN-PAGE (blue native polyacrylamide gel electrophoresis) revealed either over or under expression of specific proteins, such as ATPase, PSI, PSII core dimer, PSII monomer and ATP synthase. The expression of multiprotein complex proteins, including PSII-core dimer and PSII-core monomer, was slightly higher for the genotype NS7774 when compared to three other genotypes for both 5 and 10 days of drought stress. Further identification of specific proteins obtained in second dimension BN-PAGE provided descriptive detail of seven proteins involved in drought resistance across all genotypes. The identified proteins are majorly involved in photosynthesis under drought stress, suggesting NS7774 as a drought tolerant genotype. Further, the proteomic results were confirmed using Immunoblot by selecting specific protein such as PsaA. Overall, from our physiological modulations and chloroplast proteomics in all genotypes, we summarized NS7774 as a resilient rootstock and the other three genotypes (NS7772, OH3312, and Green Gold) as sensitive ones.
Relationship of board diversity with firm’s financial performance: The case of publicly listed companies in China

This study examines the impact of board diversity including the gender, nationality, and independence of board members on the financial performance of publicly listed companies in China. This study uses a sample of 206 publicly listed companies on the Shanghai Stock Exchange and the Shenzhen Stock Exchange in China to measure the impact of board diversity on their financial performance. Organizational financial performance is measured with the widely-used accounting-based measurement tool return on asset (ROA), and the market value measurement tool Tobin’s Q. After applying a hierarchical regression analysis this study finds that women on the board impact positively on firm’s financial performance while measures by ROA, but not by Tobin’s Q. The study also finds that the nationality of directors and independent board membership is found to have no significant influence on firms’ financial performance. This study has implications on the business firms to develop the strategic guidelines of board composition to ensure the effectiveness and profitability of their companies
Simulation of an Oxic-Settling-Anaerobic Pilot Plant Operated under Real Conditions Using the Activated Sludge Model No.2d

Oxic-settling-anaerobic (OSA) process has been introduced into the treatment line of wastewater in order to upgrade activated sludge processes and to reduce the production of excess sludge. The aim of the present study was to simulate the performance of an OSA pilot plant by implementing the Activated Sludge Model No.2d (ASM2d) into a mathematical modelling software (BioWin). The stepwise calibration, performed both by off-line experiments and software dynamic calibration, was carried out in a heuristic way, adjusting the parameters values that showed a major influence to the effluent and internal concentrations. All the reduction factors introduced into ASM2d to simulate the processes occurring in anoxic and anaerobic conditions were lowered in order to reproduce the concentrations of interest. In addition, the values of parameters of the PAOs (polyphosphate accumulating organisms)-related process (namely qPHA and YPO4) were found lower than those usually adopted. In general, theoretical results were in good agreement with the experimental data obtained from plant’s operation, showing an accurate predictive capacity of the model. Good performance was achieved considering the phosphorus removal related process, while some failures were detected in COD and ammonia simulations.
Relationships between care burden, resilience, and depressive symptoms among the main family caregivers of stroke patients: A cross-sectional study

Objectives This study aims to explore the potential mediating role of resilience between care burden and depressive symptoms in family caregivers of stroke patients. Methods A cross-sectional study was conducted with a convenience sample involving 245 main family caregivers of stroke patients recruited from the neurology department of a Tertiary A hospital in China. Mediation analyses were conducted using the PROCESS macro (Model 4) for SPSS, applying the Bootstrap analysis with 5,000 samples and a 95% confidence interval. Results The results showed that with constant hemiplegia side, Barthel Index, education level, monthly income, care time per day, and living with patients in regression equations, the resilience partially mediated the correlation of care burden and depressive symptoms with a mediation effect ratio of 26.32%. Conclusions Resilience plays a mediating role in the correlation between care burden and depressive symptoms. Impact The findings indicated a protective effect of resilience in alleviating the negative influences of care burden on depressive symptoms, suggesting that resilience-training intervention may be developed to mitigate depressive symptoms of the main family caregivers of stroke patients.