Miracle-dz/UniFAR-FTUs huggingface dataset:
Reconstruction of the pectoral girdle and forelimb musculature of Megaraptora (Dinosauria: Theropoda)

Megaraptora is a group of enigmatic, carnivorous non‐avian theropod dinosaurs from the Cretaceous of Asia, Australia, and especially South America. Perhaps the most striking aspect of megaraptoran morphology is the large, robustly constructed forelimb that, in derived members of the clade, terminates in a greatly enlarged manus with hypertrophied, raptorial unguals on the medialmost two digits and a substantially smaller ungual on digit III. The unique forelimb anatomy of megaraptorans was presumably associated with distinctive functional specializations; nevertheless, its paleobiological significance has not been extensively explored. Here we draw from observations of the pectoral girdle and forelimb skeletons of Megaraptora and myological assessments of other archosaurian taxa to provide a comprehensive reconstruction of the musculature of this anatomical region in these singular theropods. Many muscle attachment sites on megaraptoran forelimb bones are remarkably well developed, which in turn suggests that the muscles themselves were functionally significant and important to the paleobiology of these theropods. Furthermore, many of these attachments became increasingly pronounced through megaraptoran evolutionary history, being substantially better developed in derived taxa such as Australovenator wintonensis and especially Megaraptor namunhuaiquii than in early branching forms such as Fukuiraptor kitadaniensis. When considered alongside previous range of motion hypotheses for Australovenator, our results indicate that megaraptorans possessed a morphologically and functionally specialized forelimb that was capable of complex movements. Notable among these were extensive extension and flexion, particularly in the highly derived manus, as well as enhanced humeral protraction, attributes that very probably aided in prey capture.
Development of a Bedside Tool to Predict the Diagnosis of Cerebral Palsy in Term-Born Neonates.

Importance Cerebral palsy (CP) is the most common abnormality of motor development and causes lifelong impairment. Early diagnosis and therapy can improve outcomes, but early identification of infants at risk remains challenging. Objective To develop a CP prognostic tool that can be applied to all term neonates to identify those at increased risk of developing CP. Design, Setting, and Participants This case-control study used data from the Canadian Cerebral Palsy Registry (data collected from January 2003 to December 2019) for children with CP and the Alberta Pregnancy Outcomes and Nutrition study (mothers enrolled from May 2009 to September 2012; data extracted in 2020) for controls. There were 2771 children with CP and 2131 controls evaluated; 941 and 144, respectively, were removed for gestational age less than 37 weeks at birth, 565 with CP removed for incomplete data, and 2 controls removed for a diagnosis of CP. Data were analyzed from April to August 2022. Exposures Potential risk factors were selected a priori based on the literature, including maternal, intrapartum, and infant characteristics. Main Outcomes and Measures Diagnosis of CP, defined as a disorder of motor function due to a nonprogressive brain abnormality before age 1 year and classified by Gross Motor Function Classification System levels I to V. Results Of 3250 included individuals, 1752 (53.9%) were male, and the median (IQR) gestational age at birth was 39 (38-40) weeks. Encephalopathy was present in 335 of 1184 infants with CP (28%) and 0 controls. The final prediction model included 12 variables and correctly classified 75% of infants, with a sensitivity of 56% (95% CI, 52-60) and specificity of 82% (95% CI, 81-84). The C statistic was 0.74 (95% CI, 71-76). Risk factors were found to be additive. A proposed threshold for screening is probability greater than 0.3, with a sensitivity of 65% (95% CI, 61-68) and specificity of 71% (95% CI, 69-73). The prognostic tool identified 2.4-fold more children with CP than would have presented with encephalopathy (odds ratio, 13.8; 95% CI, 8.87-22.65; P < .001). Conclusions and Relevance In this case-control study, a prognostic model using 12 clinical variables improved the prediction of CP compared with clinical presentation with encephalopathy. This tool can be applied to all term newborns to help select infants for closer surveillance or further diagnostic tests, which could improve outcomes through early intervention.
A statistical study of luminosity profiles of galaxies using spheroid-disk composite models

Les distributions de la luminosite de 167 galaxies avec V 26 ≤14 mag et log D 26 [0,1')≥1,3 dans l'amas de virgo et dans les nuages Ursa Major ont ete decomposees en deux parties: un disque (loi en r 1/4 et un spheroide (loi exponentielle)
Immunophenotypical profiling of myeloid neoplasms with erythroid predominance using mass cytometry (CyTOF)

Acute erythroid leukemia (AEL) is a disease continuum between Myelodysplastic syndrome (MDS) and Acute myeloid leukemia (AML) with the cellular hallmark of uncontrolled proliferation and impaired differentiation of erythroid progenitor cells. First described by Giovanni di Guglielmo in 1917 AEL accounts for less than 5% of all de novo AML cases. There have been efforts to characterize AEL at a molecular level, describing recurrent alterations in TP53, NPM1 and FLT3 genes. A genomic analysis of AEL cases confirmed its complexity. Despite these advances, the biology underlying erythroid proliferations remains unclear and the prognosis is dismal with a median survival of only 3 months for pure erythroid leukemia (PEL). Marker combinations suitable for the identification and characterization of leukemic stem cell (LSC) candidates, monitoring measurable residual disease (MRD) during chemotherapy treatment and the development of innovative targeted therapies are missing. Here, we developed a mass cytometry panel for an in‐depth characterization of erythroid and myeloid blast cell populations from human AEL bone marrow samples in comparison to other AML subtypes and healthy counterparts. A total of 8 AEL samples were analyzed and compared to 28 AML samples from different molecular subtypes, healthy bone marrow counterparts (n = 5) and umbilical cord blood (n = 6) using high‐dimensional mass cytometry. Identification of erythroid and myeloid blast populations in high‐dimensional mass cytometry data enabled a refined view on erythroblast differentiation stages present in AEL erythroid blasts and revealed immunophenotypical profiles specific to AEL. Profiling of phenotypic LSCs revealed aberrant erythroid marker expression in the CD34+CD38− stem cell compartment. In addition, the identification of novel candidate surface marker combinations and aberrancies might enhance clinical diagnostics of AEL. We present a high‐parameter mass cytometry approach feasible for immunophenotypical analysis of blast and stem cell populations in myeloid neoplasms with erythroid predominance laying the foundation for more precise experimental approaches in the future.
Nutritional status and its associated factors among under five years Muslim children of Kapilvastu district, Nepal

Background Malnutrition is a major public health problem throughout the world especially in Southeast Asia. This study aims to find out nutritional status and its associated factors among under five Muslim children of Kapilvastu district Nepal. Methods Community based cross-sectional study was conducted among 336 under five Muslim children in Kapilvastu district Nepal from December 2021 to May 2022. Multistage probability random sampling was used. Among ten local units, three were selected randomly. Then from selected three units, two wards from each unit which covers large proportion of Muslim were selected purposively. After selecting wards, listing of household having children 6 to 59 months was done with the help of Female Community Health Volunteers and 56 children were selected by simple random sampling from each wards. Results About half of Muslim children were underweight, 0.9% were overweight, 17.3% were wasted and 63.1% were stunted. Children with >4 members in family (AOR = 2.82, CI: 1.25–6.38), joint/extended family (AOR = 0.33, CI: 0.16–0.68), living with other than parents (AOR = 2.68, CI: 1.38–5.21), mother having primary (AOR = 2.59, CI: 1.09–6.10) and fathers having SLC and above education (AOR = 0.41, CI: 0.19–0.89), school going children (AOR = 0.27, CI: 0.15–0.48), no having agricultural land (AOR = 2.68, CI: 1.55–4.65), history of chronic diseases (AOR = 3.01, CI = 1.06–8.54) were significantly associated with underweight. Mothers having secondary (AOR = 0.30, CI: 0.10–0.88) and fathers having primary education (AOR = 3.50, CI: 1.26–9.74), school going children (AOR = 0.16, CI: 0.06–0.41), no having own land (AOR = 4.73, CI: 2.13–10.48), history of child chronic disease (AOR = 3.55, CI = 1.38–9.12) were significantly associated with wasting. Similarly, male children (AOR = 1.70, CI: 1.01–2.85), living in rural area (AOR = 0.17, CI: 0.09–0.31), joint/extended family (AOR = 0.28, CI: 0.13–0.64), living with other than parents (AOR = 3.71, CI: 1.84–7.49), fathers having secondary education (AOR = 0.50, CI: 0.27–0.94) and no having own land (AOR = 1.95, CI: 1.13–3.37) were significantly associated with stunting. Conclusions Underweight, wasting and stunting in under-five Muslim children were above the cutoff point from the significant level of public health and higher than national data. Hence, this study suggests collaborative and immediate attention from responsible governmental and non-governmental organizations working in nutrition for providing informal learning opportunity, intervention regarding parental support to child, school enrolment at appropriate age, prevention and treatment of children’s chronic diseases, intervention for income generating activities and addressing problems of household food insecurity among Muslim communities.
Nonuniqueness in inverse source and scattering problems

The fields radiated by spherically symmetric time-harmonic sources are used to illustrate how little can be learned about a source from knowledge of the radiated field outside of the source volume. It is shown that even if it is known that the source is spherically symmetric, it is not possible to determine its radial structure. Moreover, even if the radial structure of the source is known apart from a constant amplitude and a finite radius, it is not possible to evaluate those two unknowns independently. These examples are applied to demonstrate explicitly that two methods that have been claimed to produce exact unique solutions to inverse-source and inverse-scattering problems do not yield the claimed results.
Effect of shear flow and magnetic field on the Rayleigh–Taylor instability

The effects of sheared equilibrium flow and magnetic field on the Rayleigh–Taylor instability (RTI) are investigated and the linear growth rate is obtained analytically in the presence of a sharp interface. It is shown that the shear flow acts as a driving force and is the dominating drive when Atwood number AT, wave number k, flow shear δu, and gravitational acceleration g satisfy k(1−AT2)δu2∕AT⪢g. As AT increases growth rate increases first and then falls down if (2kδu2)<g is satisfied, and otherwise it rises monotonically. When magnetic stabilizing effect governs, RTI only occurs in the long wave region and not only the permitted band, 0<k<gAT∕[vra2−δu2(1−AT2)], is extended but the instability is enhanced as δu increases or the reduced Alfven speed vra decreases. For regime governed by the destabilizing effect of shear flow, growth rate increases as k and δu increase.
Ingroup Positivity and Outgroup Negativity Jointly Motivate Toddlers’ Social Behavior

Abstract Intergroup bias has been a pervasive phenomenon throughout human history, but its psychological underpinnings are still the subject of debate. The present work tests whether intergroup attitudes and behaviors are motivated by ingroup positivity, outgroup negativity, or both, across the first few years of life. In two studies (total N = 128), children were introduced to an ingroup doll and an outgroup doll, and interacted with each one independently in a resource allocation task. Toddlers showed both ingroup positivity and outgroup negativity (Study 1). Preschoolers shifted from this pattern, showing positivity and avoiding negativity toward both ingroup and outgroup members (Study 2). Together, these studies suggest that outgroup negativity plays a stronger role in motivating early intergroup bias than previously thought.
Real‐world assessment of treatment patterns and outcomes in patients with relapsed‐refractory multiple myeloma in an Italian haematological tertiary care centre

Despite significant improvements in therapeutic options, multiple myeloma (MM) patients experience a series of remissions and relapses requiring further lines of therapy (LOTs). We analysed treatment pathways, attrition rates (ARs) and refractoriness patterns across LOTs in 413 MM patients treated from 2011 and 2021. Across LOT‐2 to LOT‐5 ARs were 26%, 27%, 34% and 37.5%, being 50% for subsequent LOTs. In univariate analysis age over 65 years, international staging system (ISS) II/III, more than two comorbidities, no transplant and no maintenance therapy were significantly associated with AR but regression analysis selected only age over 65 years and more than 2 comorbidities. Median progression‐free survival (PFS) was 40.5, 19.5, 10.3, 6 and 4.7 months from LOT‐1 to LOT‐5. Lenalidomide‐refractory patients, among those relapsed after LOT‐1, were 26% and 64.5% respectively, in patients starting therapy before 2019 versus in or after 2021. In the two cohorts, 57.5% and 85.5% of patients relapsed after LOT‐2 were lenalidomide‐refractory. Among patients not relapsed from LOT‐1, 80% are receiving continuous lenalidomide and could become lenalidomide‐refractory, whereas 91% and 51.5% of patients in LOT‐2 could become potential lenalidomide‐ and daratumumab‐refractory respectively. In our analysis the rate of patients reaching subsequent LOTs was higher than previously reported and the increase in early refractoriness would require faster and more efficient treatment licensing processes.
Upper limb prostheses: bridging the sensory gap

Replacing human hand function with prostheses goes far beyond only recreating muscle movement with feedforward motor control. Natural sensory feedback is pivotal for fine dexterous control and finding both engineering and surgical solutions to replace this complex biological function is imperative to achieve prosthetic hand function that matches the human hand. This review outlines the nature of the problems underlying sensory restitution, the engineering methods that attempt to address this deficit and the surgical techniques that have been developed to integrate advanced neural interfaces with biological systems. Currently, there is no single solution to restore sensory feedback. Rather, encouraging animal models and early human studies have demonstrated that some elements of sensation can be restored to improve prosthetic control. However, these techniques are limited to highly specialized institutions and much further work is required to reproduce the results achieved, with the goal of increasing availability of advanced closed loop prostheses that allow sensory feedback to inform more precise feedforward control movements and increase functionality.
Comparison of vitamin D levels in diabetes mellitus patients with and without diabetic foot ulcers: An analytical observational study in Jakarta, Indonesia

Diabetic foot ulcer (DFU) is a form of chronic wound which becomes a serious complication in diabetes mellitus (DM). Recently, the role of vitamin D on T cell‐mediated immunity, pancreatic insulin secretion, and its mechanism on cell growth and healing processes have been reported. This study aims to compare the vitamin D level of DM patients with DFU and without DFU to assess the duration and severity of DFU and its correlation with vitamin D levels. The sociodemographic characteristics and DFU duration were documented. The severity was examined in accordance with PEDIS classification. 25‐hydroxyvitamin D (25[OH]D) was analysed using in‐vitro chemiluminescent immunoassay (CLIA). Statistical analysis was performed and the P‐value <. 05 was considered as statistically significant. The vitamin D levels in DM patients with and without DFU were 8.90 ng/mL (6.52–10.90) and 16.25 ng/mL (13–19.59), respectively, with P < . 001. There was no correlation between the duration of DFU and DFU severity by PEDIS score with vitamin D levels. Vitamin D levels in DM patients with DFU are lower than those in patients without DFU. However, there was insufficient evidence to conclude that there is no correlation between the DFU duration and DFU severity by PEDIS score with vitamin D levels.
The Quest for the Optimum Longitudinal Fin Profile

This discussion is intended to set the optimum fin problem, and not just the optimum profile, in its proper prospective. In the first part, the authors' basic concepts are discussed and the mathematical formulation of the optimum fin problem is set forth. Subsequently, the Schmidt-Duffin problem is analyzed from a different point of view than that of the authors. Three examples serve to highlight the thermal performance differences of various fin profiles
Scattering of a Gaussian beam by a homogeneous dielectric cylinder

The scattering of a Gaussian beam considering amplitude and phase distribution by a homogeneous dielectric cylinder is analyzed. A simpler expression is successfully obtained by using a new method. The spatial pictures in the amplitude and phase of the total Gaussian beam near the cylinder are both theoretically and experimentally clarified. The scattering patterns are also presented.
The role of phenylalanine levels in the neuropsychological and neuroanatomical status of adult patients with phenylketonuria: The impact of fluctuations

We aimed to evaluate the role of plasma phenylalanine (Phe) levels and its fluctuations in some neurocognitive domains and brain magnetic resonance imaging (MRI) findings in adult patients with phenylketonuria (PKU). It was an observational study that included patients older than 18 years with early-treated classical PKU. Plasma Phe levels were measured every other month throughout 2 years and predictor variables were the mean, maximum (max), minimum (min), range (min–max), and plasma Phe levels at the time of cognitive testing. Patients were evaluated for executive function, processing speed, visual attention, and fluid cognitive abilities using the Trail Making Test (TMT) and for the presence of brain MRI abnormalities. In all, 22 patients with a mean age of 34 years were included, of which 18 (81%) were women. Patients with higher range and maximum Phe levels had a poorer time-based performance on TMT form A and form B. Patients with brain MRI abnormalities had higher range, maximum, and mean Phe levels. Range of Phe levels showed a good performance for MRI abnormalities (area under the curve (AUC): 0.881, standard error (SE): 0.095, 95% CI: 0.695–0.999, p = 0.044) and for the poorest time-based performances on TMT form A (AUC: 0.822, SE: 0.092, 95% CI: 0.641–0.999, p = 0.024) and B (AUC: 0.816, SE: 0.094, 95% CI: 0.632–0.999, p = 0.021). Greater Phe variability may have a negative impact on some neurocognitive domains and could be related to the severity of brain structural damage in adult patients with PKU.
PRMT1 driven PTX3 regulates ferritinophagy in glioma

ABSTRACT Mutations in the Krebs cycle enzyme IDH1 (isocitrate dehydrogenase (NADP(+)) 1) are associated with better prognosis in gliomas. Though IDH1 mutant (IDH1R132H) tumors are characterized by their antiproliferative signatures maintained through hypermethylation of DNA and chromatin, mechanisms affecting cell death pathways in these tumors are not well elucidated. On investigating the crosstalk between the IDH1 mutant epigenome, ferritinophagy and inflammation, diminished expression of PRMT1 (protein arginine methyltransferase 1) and its associated asymmetric dimethyl epigenetic mark H4R3me2a was observed in IDH1R132H gliomas. Reduced expression of PRMT1 was concurrent with diminished levels of PTX3, a key secretory factor involved in cancer-related inflammation. Lack of PRMT1 H4R3me2a in IDH1 mutant glioma failed to epigenetically activate the expression of PTX3 with a reduction in YY1 (YY1 transcription factor) binding on its promoter. Transcriptional activation and subsequent secretion of PTX3 from cells was required for maintaining macroautophagic/autophagic balance as pharmacological or genetic ablation of PTX3 secretion in wild-type IDH1 significantly increased autophagic flux. Additionally, PTX3-deficient IDH1 mutant gliomas exhibited heightened autophagic signatures. Furthermore, we demonstrate that the PRMT1-PTX3 axis is important in regulating the levels of ferritin genes/iron storage and inhibition of this axis triggered ferritinophagic flux. This study highlights the conserved role of IDH1 mutants in augmenting ferritinophagic flux in gliomas irrespective of genetic landscape through inhibition of the PRMT1-PTX3 axis. This is the first study describing ferritinophagy in IDH1 mutant gliomas with mechanistic details. Of clinical importance, our study suggests that the PRMT1-PTX3 ferritinophagy regulatory circuit could be exploited for therapeutic gains. Abbreviations: 2-HG: D-2-hydroxyglutarate; BafA1: bafilomycin A1; ChIP: chromatin immunoprecipitation; FTH1: ferritin heavy chain 1; FTL: ferritin light chain; GBM: glioblastoma; HMOX1/HO-1: heme oxygenase 1; IHC: immunohistochemistry; IDH1: isocitrate dehydrogenase(NADP(+))1; MDC: monodansylcadaverine; NCOA4: nuclear receptor coactivator 4; NFE2L2/Nrf2: NFE2 like bZIP transcription factor 2; PTX3/TSG-14: pentraxin 3; PRMT: protein arginine methyltransferase; SLC40A1: solute carrier family 40 member 1; Tan IIA: tanshinone IIA; TCA: trichloroacetic acid; TEM: transmission electron microscopy; TNF: tumor necrosis factor
Current Helicity of the Large-Scale Photospheric Magnetic Field

This paper presents the first results of a study of current helicity of the large-scale magnetic field (LSMF) using full-disk longitudinal Blong magnetograms from the Michelson Doppler Imager on board the SOHO spacecraft. We employ a known technique to reconstruct the vector magnetic field under the assumption of relatively slow evolution of the LSMF and treat the variations of Blong, occurring during a defined period of time as the result of the changing projection angle only. We compute the synoptic maps of radial (Br) and toroidal (Bλ) magnetic fields and the latitudinal profile of current helicity density hc = Br(𝛁 ×)r. For eight solar rotations (1910-1917) that have been analyzed, hc shows significant variations within ±40° of solar latitude with no strong hemispheric sign asymmetry. Asymmetry is present, however, in high latitudes, where hc is negative/positive in the northern/southern hemisphere.