Miracle-dz/UniFAR-FTUs huggingface dataset:
Location of economic activities in the Ostrava metropolitan area (Czech Republic): focused on brownfield redevelopment

There are a number of research themes related to location of economic activities. Brownfield redevelopment or comparison of brownfields and greenfields belong to them. Note that the importance of these themes is given by their close relationship to sustainable development principles. Generally, location characteristics of brownfields are regarded as worse than location characteristics of greenfields. In this regard, several barriers of brownfield redevelopment are repeated in scholarly literature. However, a complex empirical research on this issue is rather limited. Thus, the intent of this paper is to contribute to the discussion on the location characteristics of brownfields, redeveloped sites and greenfields. We chose the Ostrava metropolitan area in the Czech Republic in the post-socialist period after the year 1989 as our case study. The research is designed as follows. First, we identified three hundred sites which satisfied our conditions (e.g. area, former use, location in the model area). These sites were classified into six categories - brownfields, partially redeveloped brownfields, sites without changes in use after the year 1989, partially redeveloped sites after 1989, redeveloped sites after 1989, and greenfields newly used after 1989. Location of economic activities was the main factor for categorization. Second, the location characteristics of all these sites were added. These included location in morphogenetic zones of the model area, ownership structure, existence of environmental burden, quality of transport accessibility and others. In this way, a data matrix of the sites and their characteristics was created. Third, relations in the data matrix were analyzed. We identified the location characteristics and their combinations which differentiated between the particular categories of the sites. Finally, a model based on the rough-set method was suggested to evaluate the development potential of brownfields. Our findings show some important conclusions. The assumptions on worse location characteristics of brownfields were confirmed but the differences between the particular categories of sites were rather not statistically significant. However, this was true for some combinations of location characteristics of brownfields. This conclusion evoked the idea on the uniqueness of brownfield redevelopment projects. In addition, our findings supported the thesis that brownfields and greenfields were two partial real estate submarkets.
Mirtazapine: neuroprotection in a DM1 mouse model

1Integrative Pharmacology and Systems Neuroscience, IMIM-Hospital del Mar Medical Research Institute, Barcelona, Spain 2Department of Experimental and Health Sciences, Pompeu Fabra University (CEXS-UPF), Barcelona, Spain. 3CIBER de la Fisiopatología de la Obesidad y la Nutrición (CIBERON), Instituto de Salud Carlos III, Madrid, Spain. 4Translational Genomics Group, Incliva Health Research Institute, Valencia, Spain. 5Interdisciplinary Research Structure for Biotechnology and Biomedicine (ERI BIOTECMED), University of Valencia, Valencia, Spain. 6CIPF-INCLIVA joint unit.
Fluvial mixing during floods

Mixing in fluvial systems, as characterised by longitudinal dispersion, may be thought intuitively to scale with the river discharge or flow rate. Here, this tenet is demonstrated theoretically to be well‐founded during normal flows but to be perfidious during flood conditions. The results suggest that during floods longitudinal mixing rates in rivers can be several orders of magnitude larger than during normal flows and can actually decrease with further increases in flow magnitude. The very large longitudinal dispersion coefficients found during extreme flows cannot be predicted using existing empirical equations; neither can the rapid decrease with increasing flow rate. This is not surprising because these equations do not cater for the extremely strong transverse velocity shear that exists in these flows that contain zones of quite different velocity and depth. The conclusions are important because it appears that the great majority of observations of fluvial mixing have been made during normal flows when a scaling with flow rate occurs. During floods, however, this behaviour switches and longitudinal dispersion scales inversely and non‐linearly with flow rate.
Parking Space Reservation based on VANETs

With the rapid increase of private vehicles, finding an available parking space in urban cities is indeed stressful, time-consuming. Reservation mechanism is a good method for solving this problem. In this paper, we present a parking space reservation method based on VANETs. Firstly, we set a Road Side Unit (RSU) at every important intersection to collect traffic information which utilizes the proposed timeprediction model to predict the travel time. Then, a parking space reservation mechanism is proposed according to a dynamic path selection based on real-time traffic information. At last, extensive evaluations using the software VanetMobisim and NS2 have been performed, and we can see the method we proposed make good travel time prediction which is useful and meaningful in parking spaces reservation for drivers and facility managers.
A petrographic study of the Challis Volcanics, White Knob Mountains, Custer County, Idaho.

The Challis Volcanics of the White Knob Mountain area, Custer Co., Idaho, consist of flows, agglomerates, and welded tuffs, as well as a single traceable obsidian layer. As defined by Ross (1961), the Challis Volcanics are: "those dominantly volcanic strata of Early Tertiary age within the part of central Idaho north of the Snake River Plain and south of the westward flowing segment of the Salmon River" In the White Knob Mountain area they have been unconformably deposited on a deformed basement of Early Mississippian to Early Permian predominantly carbonate rocks and, locally, an intervening wedge of the Eocene Smiley Creek Conglomerate. Elsewhere in Idaho, Ross (1934 and 1937) divided the Challis Volcanics into four members: the latite-andesite member, the Germer tuffaceous member, the basalt flow member, and the Yankee Fork rhyolite member, but according to Nelson and Ross (1969), only the latite-andesite member is present in the White Knob Mountains. Local pockets of a volcanogenic sandstone were found to unconformably overlie the Challis Volcanics in the study area. This sandstone exhibits graded and cross-bedding, and has thin intercalated volcanic flows. A boulder conglomerate is found at the base of this sandstone, which has a maximum measured thickness of 9 m (30 ft . ) . Several intrusions are also found in the White Knob Mountains but only two are of major proportions. The two major intrusions are the Castle Rock Intrusive, which is a diorite, and the Porphyry Peak Intrusive, which is a syeni te . Petrographic study of the Challis Volcanics revealed that they are composed of the following rock types; flows ranging from basalt to dacite, with'andesite being the most common composition, agglomerates ranging from andesite to dacite, with andesite being the most common composition, and welded tuffs which are dominantly andesitic in composition. Comparison of the results of the petrographic study with the complete section of the Challis Volcanics of Ross (1937) indicates that Nelson and Ross (1969) were correct in their conclusion that only the latite-andesite member of the Challis is present in the White Knob Mounta ins. Several faults occur in the study area cutting the Challis units. These indicate Late Tertiary or Early Quaternary deformation in the White Knob Mountains.
The Molucca Sea Collision Zone, Indonesia

The convex north trending Sangihe and Halmahera volcanic arcs face each other and are underlain by oppositely dipping Benioff zones whose surface intersection in the Molucca Sea forms a zone of crustal collision. Seismic reflection profiles across the Talaud-Mayu ridge between the arcs demonstrate that this topographic high consists exclusively of deformed rocks. Reflection profiles further indicate that this deformed mass, or collision complex, is being obducted onto the flanking arc aprons on both east and west sides along gently dipping thrust faults which crop out in troughs adjacent to the arcs. The near-surface layers of the arc apron are being incorporated into the collision complex by either plastic deformation or thrusting of coherent sediment wedges. Preliminary gravity and seismic refraction interpretation indicate that at least 8–10 km of low-density material underlies the Talaud-Mayu ridge. The total length of lithosphere subducted by the colliding arcs is at least 1000 km, the length of the Benioff zones. The geometry of the collision zone suggests an obductive mechanism for emplacement of melange and ophiolite belts against island arcs or continental margins. The central part of the mostly submarine Talaud-Mayu ridge stands 1–3 km higher than the flanking troughs, wherein the thrusts crop out. Gravitational flow of material outward and downslope away from the high translates at the edges to thrusting up over the adjacent arcs. The reconstructed history of the collision predicts at least two opposing vergence directions developed in the deformed rocks of the collision complex. The first, developed during subduction, verges away from the arcs, whereas the second, developed during the present phase of collision, verges towards the arcs. Thus vergence indicators alone are probably equivocal determiners of subduction polarity in ancient rocks.
Abbreviated Title : DACC Motivated Task Performance Dorsal Anterior Cingulate Cortex Encodes the Integrated Incentive Motivational Value of Cognitive Task Performance

Acknowledgments The research was supported by the National Institutes Health (R21-AG058206, R21-AG067295 to T.S.B. and subaward R24-AG054355 D.M.Y.) and McDonnell Center for Systems Neuroscience (T.S.B. and D.M.Y.). D.M. Y. and J.L. C. were supported by T32-AG000030, and D.M. Y. was additionally supported by F31-DA042574 and T32-NS073547. We would like to thank Carolyn Dean Wolf, Katherine Shapiro, and Bidhan Lamichhane for their assistance with data collection and technical support. We also thank Amitai Shenhav, Katherine Conen, and the CCP and Shenhav labs for helpful discussions during manuscript preparation.
Endocrine and metabolic disorders in adolescent and adult patients born small for gestational age

Children born small for gestational age (SGA), defined by a birth weight and/or length standard deviation score (SDS) of < −2 based on an appropriate reference population, represent a diverse group due to multiple underlying causes of reduced growth. This classification results in a heterogeneous patient cohort. SGA children are prone to endocrinological and metabolic issues not only in childhood but also extending into adolescence and adulthood. This population faces elevated health risks, including persistent short stature, premature adrenarche, pubertal development alterations, neurocognitive problems, and metabolic syndrome. Insulin resistance emerges as a pivotal factor contributing to these metabolic complications, prominently featuring obesity, insulin resistance, hypertension, and an increased risk of type 2 diabetes mellitus in adulthood. These medium- to long- term complications significantly impact their quality of life. Growth hormone (GH) therapy for short children born SGA facilitates height normalization throughout childhood, adolescence, and into adulthood. Catch-up growth, however, correlates with heightened risks of obesity, insulin resistance, and metabolic syndrome. Conversely, those without catch-up growth tend to exhibit pronounced short stature and cognitive dysfunction. Given these determinants, comprehensive management and clinical monitoring of SGA children should commence in the neonatal period and extend into adulthood. Recognizing and addressing these challenges early in life can mitigate the long-term impact on health and well-being, emphasizing the importance of a lifelong approach to their care.
Title : Archaic introgression and variation in pharmacogenes and implications for local adaptation

Modern humans carry Neanderthal and Denisovan (archaic) genome elements which may have been adaptive. These effects may be particularly evident in pharmacogenes – genes responsible for the processing of exogenous substances such as food, pollutants, and medications. However, the health implications and contribution of archaic ancestry in pharmacogenes of modern humans remains understudied. We characterize eleven key cytochrome P450 (CYP450) genes involved in drug metabolizing reactions in three Neanderthal and one Denisovan individuals and examine archaic introgression in modern human populations. We infer the metabolizing efficiency of these eleven genes in archaic individuals and show important genetic differences relative to modern human variants. We identify archaic-specific SNVs in each CYP450 gene, including some that are potentially damaging, which may result in altered metabolism in modern human people carrying these variants. We highlight four genes which display interesting patterns of archaic variation: CYP2B6 – we find a large number of unique variants in the Vindija Neanderthal, some of which are shared with a small subset of African modern humans; CYP2C9 – containing multiple variants that are shared between Europeans and Neanderthals; CYP2A6*12 – a variant defined by a hybridization event that was found in humans and Neanderthals, suggesting the recombination event predates both species; and CYP2J2 – in which we hypothesize a Neanderthal variant was re-introduced in non-African populations by archaic admixture. The genetic variation identified in archaic individuals suggests that selective pressures from the environment may be involved in the evolution of CYP450 genes.
Decentralized Data-driven Optimal Control for the Microgrid

Recent advances in climate change policies and sustainable energy systems are spurring the widespread deployment of microgrids. The main operational challenge of these systems is the lack of inertia (in islanded mode) that is typically present in the main grid. To preserve the stable operation of the system, efficient control algorithms are necessary. In this paper, we present a novel optimal control algorithm that leverages constructs from machine learning to decouple interactions between various actuating power components in the microgrid. This allows every actuating entity to make control decisions based only on local measurements. As no communication is necessary with our proposed control algorithm, vulnerabilities and delays that are typically associated with communication-based control algorithms are eliminated. Also, in contrast to traditional decentralized techniques (e.g. droop-based) that are myopic in nature, our algorithm allows for the tracking of the original setpoint without any offsets as the global interactions are accounted for by the machine learning component of the proposed algorithm. We demonstrate the performance, stability and scalability of our proposal via practical simulations conducted on a 15-bus microgrid system.
Eocene partial melting recorded in peritectic garnets from kyanite-gneiss, Greater Himalayan Sequence, central Nepal

Abstract Anatectic melt inclusions (nanogranites and nanotonalites) have been found in garnet of kyanite-gneiss at the bottom of the Greater Himalayan Sequence (GHS) along the Kali Gandaki valley, central Nepal, c. 1 km structurally above the Main Central Thrust (MCT). In situ U–Th–Pb dating of monazite included in garnets, in the same structural positions as melt inclusions, allowed us to constrain partial melting starting at c. 41–36 Ma. Eocene partial melting occurred during prograde metamorphism in the kyanite stability field (Eo-Himalayan event). Sillimanite-bearing mylonitic foliation wraps around garnets showing a top-to-the-SW sense of shear linked to the MCT ductile activity and to the exhumation of the GHS. These findings highlight the occurrence of an older melting event in the GHS during prograde metamorphism in the kyanite stability field before the more diffuse Miocene melting event. The growth of prograde garnet and kyanite at 41–6 Ma in the MCT zone, affecting the bottom of the GHS, suggests that inverted metamorphism in the MCT zone and folded isograds in the GHS should be carefully proved with the aid of geochronology, because not all Barrovian minerals grew during the same time span and they grew in different tectonic settings.
Development of a Physiologically Based Pharmacokinetic Model for Nitrofurantoin in Rabbits, Rats, and Humans

Nitrofurantoin (NFT) is a commonly used antibiotic for the treatment of urinary tract infections that can cause liver toxicity. Despite reports of hepatic adverse events associated with NFT exposure, there is still limited understanding of the interplay between NFT exposure, its disposition, and the risk of developing liver toxicity. In this study, we aim to develop a physiologically based pharmacokinetic (PBPK) model for NFT in three different species (rabbits, rats, and humans) that can be used as a standard tool for predicting drug-induced liver injury (DILI). We created several versions of the PBPK model using previously published kinetics data from rabbits, and integrated enterohepatic recirculation (EHR) using rat data. Our model showed that active tubular secretion and reabsorption in the kidney are critical in explaining the non-linear renal clearance and urine kinetics of NFT. We subsequently extrapolated the PBPK model to humans. Adapting the physiology to humans led to predictions consistent with human kinetics data, considering a low amount of NFT to be excreted into bile. Model simulations predicted that the liver of individuals with a moderate-to-severe glomerular filtration rate (GFR) is exposed to two-to-three-fold higher concentrations of NFT than individuals with a normal GFR, which coincided with a substantial reduction in the NFT urinary concentration. In conclusion, people with renal insufficiency may be at a higher risk of developing DILI due to NFT exposure, while at the same time having a suboptimal therapeutic effect with a high risk of drug resistance. Our PBPK model can in the future be used to predict NFT kinetics in individual patients on the basis of characteristics like age and GFR.
Self-Regulation: The Link between Academic Motivation and Executive Function in Urban Youth

The present study investigated the relationship between academic motivation and executive function skills through teacher reports of prototypical students, perceived to lack motivation. Second, the study examined the effect of grade level (i.e., elementary, middle, high) on both teacher-perceived academic motivation and executive function skills for these prototypical students. It was hypothesized that there were significant relationships between executive function processes and academic motivation. It was also hypothesized that due to the decline in academic engagement during adolescence, middle school and high school teachers would perceive higher levels of executive dysfunction and deficits in academic motivation than would elementary teachers. The study used archival data from the Behavior Rating Inventory of Executive Function (BRIEF) and the Motivation subscale of the Academic Competence Evaluation Scales (ACES) completed by teachers in an urban charter school during several faculty meetings. Statistically significant findings were obtained, indicating that teachers’ ratings of the executive function capacities of unmotivated students were consistent with the hypothesis that academic motivation and executive function skills are significantly correlated. Significant correlations were found between academic motivation and the areas of Shift, Emotional Control, the Behavioral Regulation Index, the Metacognition Index, and the Global Executive Composite scales of the BRIEF. Results of the analyses also reveal that high school teachers perceive higher levels of executive dysfunction than do elementary and middle school teachers in the areas of Plan/Organize, Organization of Materials, and on the Metacognition Index of the BRIEF. Additionally, high school teachers Motivation and Executive Functioning vi reported more significant executive function difficulties than elementary school teachers on the Shift, Initiate, Working Memory, Monitor, and Global Executive Composite scales of the BRIEF. Results supported the hypothesis that teacher perceived executive function skills decline as students age; however, motivational deficits did not change as a function of grade level. Motivation and Executive Functioning vii
PARTNERS IN CRIME : THE EFFECTS OF DIVERSITY ON THE LONGEVITY OF CARTELS OLIVIER BERTRAND

Despite the importance of organizational misconduct, still not much is known about coordinated misconduct between firms. In this study, we seek a better understanding of how the profile of the partners involved in cartels affects the longevity of their joint misconduct activities. Drawing upon diversity theory, we leverage a distinction between three types of diversity—variety of age-based experience, separation in uncertainty avoidance, and power disparity—in collective organizational misconduct between firms, and study their respective influence on the longevity of cartels. Our empirical analysis gives support to our main arguments: the longevity of cartels tends to be increased by the level of variety of age-based experience and power disparity between partners but reduced by their level of separation in uncertainty avoidance. Implications for the literature on organizational misconduct are discussed.
THE IMPACT OF DAYLENGTH ON TURKEY PRODUCTIVITY, HEALTH AND BEHAVIOUR

i ACKNOWLEDGEMENTS . iii TABLE OF CONTENTS . iv LIST OF TABLES . vii LIST OF FIGURES . x LIST OF ABBREVIATIONS . xi 1.0: INTRODUCTION . 1 2.0: LITERATURE REVIEW . 4 2.1 Lighting Programs . 4 2.2 Impact of Light on Production . 8 2.2.1 Growth and Feed Consumption . 8 2.2.2 Feed Efficiency . 11 2.3. 3 Mortality . 12 2.3 Defining Animal Welfare . 13 2.4 Impact of Light on Health and Behaviour . 15 2.4. 1 Mobility (GS, FPD, Breast Blisters) . 15 2.4. 2 Ocular Health . 19 2.4. 3 Behaviour . 20 2.5 Conclusion and Research Objective . 23 3.0: THE IMPACT OF GRADED LEVELS OF DAYLENTH ON TURKEY PRODUCTIVITY TO 18 WK OF AGE 3.1 Abstract . 24
Late Miocene crocodylians from northeast Argentina: new approaches about the austral components of the Neogene South American crocodylian fauna

ABSTRACT The richest and more explored regions concerning Miocene crocodylians in South America are the basins surrounding the areas of Urumaco (Venezuela), La Venta (Colombia), Acre (Northwest Brazil) and Paraná (Northeast Argentina). Fossils from the late Miocene in the Paraná area were recovered from the “Conglomerado Osífero” (Ituzaingó Formation) and assigned to several taxa of Caimaninae (Alligatoroidea) and to a taxon of Gavialoidea. The late Miocene “fauna” of crocodylians recorded in northeast Argentina differs from coeval ones of northern South America by the absence of crocodyloids, some alligatorid genera (such as Purussaurus, Melanosuchus, and Paleosuchus) and by the scarce gavialoid species. Giant forms, conspicuous in the northern South American deposits, are also absent in southern latitudes. Despite this, the austral South American crocodylian fauna exhibits strong affinities with the northern, contemporary forms, sharing taxa at generic (i.e. Caiman and Gryposuchus) and even specific levels (i.e. Mourasuchus nativus). The sharing of such freshwater taxa in the Miocene indicates partial connections of drainage basins through swamp areas on their boundaries, and is evidence against the assumption of an intracontinental coeval seaway link in this continent proposed by several authors.