Miracle-dz/UniFAR-FTUs huggingface dataset:
Role of CB1 Cannabinoid Receptors in Vascular Responses and Vascular Remodeling of the Aorta in Female Mice

Both the endocannabinoid system (ECS) and estrogens have significant roles in cardiovascular control processes. Cannabinoid type 1 receptors (CB1Rs) mediate acute vasodilator and hypotensive effects, although their role in cardiovascular pathological conditions is still controversial. Estrogens exert cardiovascular protection in females. We aimed to study the impact of ECS on vascular functions. Experiments were performed on CB1R knockout (CB1R KO) and wild-type (WT) female mice. Plasma estrogen metabolite levels were determined. Abdominal aortas were isolated for myography and histology. Vascular effects of phenylephrine (Phe), angiotensin II, acetylcholine (Ach) and estradiol (E2) were obtained and repeated with inhibitors of nitric oxide synthase (NOS, Nω-nitro-L-arginine) and of cyclooxygenase (COX, indomethacin). Histological stainings (hematoxylin-eosin, resorcin-fuchsin) and immunostainings for endothelial NOS (eNOS), COX-2, estrogen receptors (ER-α, ER-β) were performed. Conjugated E2 levels were higher in CB1R KO compared to WT mice. Vasorelaxation responses to Ach and E2 were increased in CB1R KO mice, attenuated by NOS-inhibition. COX-inhibition decreased Phe-contractions, while it increased Ach-relaxation in the WT group but not in the CB1R KO. Effects of indomethacin on E2-relaxation in CB1R KO became opposite to that observed in WT. Histology revealed lower intima/media thickness and COX-2 density, higher eNOS and lower ER-β density in CB1R KO than in WT mice. CB1R KO female mice are characterized by increased vasorelaxation associated with increased utilization of endothelial NO and a decreased impact of constrictor prostanoids. Our results indicate that the absence or inhibition of CB1Rs may have beneficial vascular effects.
Compromising, Avoiding, or Bullying? A Mixed Method Approach to Understanding Conflict Resolution and Bullying Among Undergraduate Roommates

While living with roommates in residence presents a unique set of challenges for emerging adults who are just beginning to navigate a world of adult responsibilities and are adjusting to living with an often-unfamiliar companion, conflicts become inevitable. Common sources of conflict, such as disputes over cleaning duties or noise levels, combine with still-developing conflict resolution skills to create an escalating environment of hostility that can develop into bullying if not properly addressed. However, what remains relatively understudied is how emerging adults navigate conflict management and how conflict resolution styles mitigate such household conflicts. Employing a multi-methods approach, this study utilized quantitative (i.e., questionnaires) and qualitative (i.e., short answer questions) methods to investigate the relative influence of conflict management styles and social support on roommate victimization and bullying among 804 undergraduate students aged 18–21 years old (79% female; M = 19). Multiple hierarchal linear regressions and thematic analyses were employed to analyze the data. The findings revealed that roommate compromise predicted an increase in roommate victimization and bullying, and an inverse relationship between resolving conflict with self-interest, where increased self-interest predicted lower roommate victimization and bullying. Social support was significantly inversely related to roommate bullying and victimization, such that increased social support tended to mitigate bullying and victimization. Taken in unison, these findings convey while students may believe they are compromising, whether they are requires further investigation. This work highlights the need to teach students how to manage conflict in healthy ways while verifying the continued importance of social support.
Bacterial community structure of microbial pinnacles in ice-covered Lake Vanda, Antarctica

ABSTRACT The McMurdo Dry Valleys are a cold and arid environment with low biomass relative to most ice-free environments. The ice-covered lakes in the valleys, however, provide a refuge for diverse microbial communities where liquid water persists year-round. Within these lakes, benthic microbial assemblages form ornate structures in the absence of burrowing and grazing organisms. In Lake Vanda, the microbial communities create pinnacles with features including tip, web, and ridge ornaments and brown, green, purple, and beige pigmented zones. Bacterial 16S rRNA gene composition differed between lake depths for all sampled features. Within each depth, community composition correlated with the relative distance into the pinnacle and there were also some significant differences between assemblages in certain zones. The bacterial community composition in the zones may reflect how they respond to environmental changes as the mat is buried, altering the internal light environment and affecting 16S rRNA gene assemblages across niches from the surface to the interior.
Difficulties in emotional regulation mediates the impact of burden on quality of life and mental health in a sample of family members of people diagnosed with Borderline Personality Disorder

Background Although it has been suggested that family members of persons suffering from Borderline Personality Disorder (BPD) endure high levels of burden, however, the process and the impact of this burden in their lives, and specifically the relation between the burden and emotional regulation has not been broadly investigated among this population. The main objective of this study is to examine the impact of burden on quality of life and depression, anxiety and stress, as mediated by difficulties in emotional regulation in family members of persons diagnosed with BPD. Method Participants were 167 family members of persons diagnosed with BPD. The Burden Assessment Scale, Difficulties in Emotion Regulation Scale, Multicultural Quality of Life Index, and Depression Anxiety Stress Scale-21 were filled out. Mediation analysis was conducted using the Maximum Likelihood estimator, bootstrap method and listwise deletion for missing data. Results Burden showed a significant, negative effect on quality of life and positive on depression, anxiety and stress. Difficulties in emotion regulation significantly mediated these relations. After accounting for the mediating role of difficulties in emotion regulation, burden still had an impact on quality of life, depression, anxiety and stress. Women showed a higher level in both burden and stress than men. The caregivers with secondary and higher studies showed higher levels in burden than those with no studies. Not significant differences in burden, emotion regulation, depression, anxiety and stress were found related to marital status. Conclusion Difficulties in emotion regulation mediate the relations between burden and quality of life, depression, anxiety, and stress. Family members could engage in group interventions designed specifically for family members of people with BPD, oriented toward understanding the disorder or learning skills.
Aerosol Radiative Effects in the Tropical Western Pacific

Atmospheric Radiation Measurement (ARM) Program observations are used to quantify the aerosol radiative effects in the climatically important Tropical Western Pacific (TWP). This quantification addresses two primary ARM objectives by (1) ascertaining the existing variability of the radiative forcing and its relationship to atmospheric composition, and (2) providing strong constraints for testing aerosol models that may be used in climate models. Since general circulation models (GCMs) often do not treat aerosols, it is important to assess the potential effects of their absence in this climatically important region.
In situ Gelling Hydroxypropyl Cellulose Formulation Comprising Cannabidiol-Loaded Block Copolymer Micelles for Sustained Drug Delivery

Cannabidiol (CBD) is a natural terpenophenolic compound with known pharmacological activities, but the poor solubility of CBD in water limits its widespread use in medicine and pharmacy. Polymeric (nano)carriers demonstrated high potential for enhancing the solubility and therapeutic activity of lipophilic drugs such as CBD. Here, we report the elaboration of a novel hydroxypropyl cellulose (HPC)-based in situ gelling formulation for controlled delivery of CBD. In the first stage, nanosized polymeric micelles from poly(ethylene oxide)-block-poly(α-cinnamyl-ε-caprolactone-co-ε-caprolactone) (PEO-b-P(CyCL-co-CL) diblock copolymers) were used to increase the solubility of CBD in water. Different copolymers were assessed, and the carrier with the highest encapsulation efficiency (EE) and drug loading capacity (DLC) was selected for further elaboration of nanocomposite in situ gel formulations. Next, the sol-to-gel transition behavior of HPC as a function of K2SO4 concentration in the aqueous solution was investigated by microcalorimetry and dynamic oscillatory rheology, and the optimal formulation capable of forming a physical gel under physiological conditions was determined. Finally, injectable nanocomposite hydrogels comprising cannabidiol were fabricated, and their drug release profile and cytotoxicity against human tumor cell lines were evaluated. The in situ gels exhibited prolonged drug release over 12 h, controlled by gel erosion, and the cytotoxicity of formulated cannabidiol was comparable with that of a free drug.
Pro-Environmental Behavior Decisions in Face Mask Usage: A Pilot Study

Human behavior and interaction with their surroundings vary from one another. Different people may engage and behave pro-environmental based on their beliefs and understanding of the consequences of environmental problems for themselves. The theory of planned behavior (TPB) and value belief norm theory (VBN) suggest that an individual perceives environmental pollution effects could influence their decision-making in daily activities. This study aimed to examine people's behavior in using face masks and their perception of environmental consequences by integrating the TPB and VBN into a single conceptual framework. This study confirms that sub-factors, including biosphere, altruism, egoistic, awareness of consequences, and personal norms, are among the predictors that explain pro-environmental behavior in Malaysia. Additionally, the cultural factor significantly mediates the behavior. A questionnaire pilot survey was conducted among 50 visitors in a coastal area in Peninsular Malaysia. The Cronbach alpha test and descriptive analysis confirm the direct and mediatory effect of the causal of the variables in the TPB and VBN theory of pro-environmental behavior when making decisions in face mask usage. The research results validate the proposed TPB and VBN theory model linkages to clarify pro-environmental behavior.
The Influence of Capital Structure, Profit Growth, Profitability and Company Size on the Quality of Earnings

This study aims to analyze the effect of capital structure, profit growth, profitability and firm size on earnings quality in manufacturing companies in the food and beverage sub-sector listed on the Indonesia Stock Exchange in 2017-2021. Sampling used purposive sampling to obtain 7 companies. The data analysis technique uses panel data which is processed with Eviews 9. Based on the partial test, the capital structure and profitability variables have a negative effect on earnings quality. While the variables of profit growth and firm size have no effect on earnings quality. Then, the results of the F test shows that there is a simultaneous influence between the variables of capital structure, profit growth, profitability and firm size on earnings quality. The result of testing the coefficient of determination is 50.71 per cent, which means the ability of the independent variable to explain earnings quality in this study is 50.71 per cent, while the remaining 49.29 per cent is influenced by other variables not used in this study.
Utilizing Special Language in Street Crime Newsgathering in Indonesia

This article describes the newsgathering process among the crime journalist community in West Java, which involves the use of special symbolic languages. Using the ethnographic method, the study was conducted to collect data related to the practice of using special language, especially how crime journalists interpret it and how it functions for their profession. The results have shown that special language is not only used in the newsgathering process but also in daily interactions with fellow community members and police officers as news sources. As a result, the special language used consists of both abstract and concrete symbols. Abstract symbols encompass verbal and nonverbal forms that are embodied in numeric, phonetic, and cosmic codes. Meanwhile, concrete symbols are related to how they dress and use equipment, and how all these attributes represent them as crime journalists. This is related to the functions of special language, namely as a means of distinguishing themselves from other journalist groups. In addition, this special language also serves as a form of identity manipulation, allowing them to take on the role of the police in information gathering.
Le régime alimentaire du Guêpier d’Europe Merops apiaster dans les parc national de l’Ichkeul (Tunisie)

Une etude du regime alimentaire du Guepier d'Europe Merops apiaster (L., 1758) a ete realisee en avril et mai 1999 dans le Parc national de l'Ichkeul (Tunisie) a partir de 138 pelotes de rejection, dans lesquelles 2 862 proies ont ete identifiees. D'une maniere generale, ces dernieres se repartissent entre 9 ordres d'Arthropodes, et les Hymenopteres y dominent largement (66,1 % des proies). Les Dipteres viennent en second (12,6 %), suivis des Coleopteres (10 %), les autres ordres etant representes de facon marginale, sinon exceptionnelle. Cependant, en avril, les Coleopteres precedent les Dipteres, alors que c'est largement l'inverse en mai. Dans l'ensemble, durant ces deux mois d'etude, le regime alimentaire du Guepier d'Europe du parc de l'Ichkeul a ete a la fois tres large par le nombre des especes-proies, et tres specialise, mais la proportion des Abeilles domestiques y etait relativement peut elevee en comparaison de ce que l'on sait d'autres localites.
Unlocking the Future of Arabic languages teaching: Exploring Communicative Language Teaching Methodology

The Communicative Language Teaching (CLT) approach is a technique centred on increasing the learner's abilities via speaking and communication activities between the instructor and the students, as well as between the students themselves. The exercises are relevant to our everyday lives, allowing the student to use the language organically and spontaneously while focusing on what may be taught and improved. Due to the desire of many students to replace traditional learning methods, such as memorization and rule learning, with interactive and innovative methods that place a greater emphasis on communication skills, this study seeks to determine the efficacy of the communicative method in teaching languages. This study found that teaching communicative language is one of the best methods for teaching languages to a variety of groups, including normal children, autistic children, and language learners, based on a review of the literature written about the communicative method in 28 studies employing diverse research methods and methodologies. Numerous linguists and scholars have utilised it as a second language. The research recommends constructing curriculum in a manner that is consistent with teaching the communicative method to students, enhancing the effectiveness of instructors, and enhancing their skills in order to reach a high level of communicative competence among students.
Architecture of the Middle Devonian Kvamshesten Group, western Norway: sedimentary response to deformation above a ramp-flat extensional fault

Abstract The Mid-Devonian Kvamshesten basin in western Norway formed during late- to post-Caledonian extensional and strike-slip tectonics. The basin is entirely continental in origin, and was probably a closed basin through most of its history. It was filled by alluvialfluvial deposits belonging to two main terminal fan systems, one sourced in the hanging wall, one sourced in the footwall of the basin-controlling fault(s). Footwall-directed migration of the hanging-wall-sourced fluvial system probably took place during phases of relatively rapid, fault-controlled subsidence. This gave rise to retrogradational stacking of marginal conglomerates and to the footwall-directed migration of the main depocentre(s). During periods of increased sediment influx from footwall catchments and/or decreased subsidence rates, coarse, footwall-sourced material prograded far into the basin. The intercalation of material derived from footwall- and hanging-wall source areas, respectively, gave rise to a pronounced, kilometre-scale rhythmicity that is inferred to reflect fault-block rotation and footwall erosion. The basin fill also displays a pronounced rhythmic organization on the 80–150 m scale. The Kvamshesten basin was deformed during deposition as a result of its position in the hanging wall of a ramp-flat extensional fault and because of extension-parallel shortening. Thus, the pattern of subsidence was non-uniform and the sediment preservation potential varied across the basin. Deposition and preservation of floodbasin fine sediments was enhanced in areas close to the breakaway of the basin-bounding fault and in the hangingwall syncline that developed above the ramp. The crest of the rollover anticline was mainly occupied by high-energy braided fluvial systems represented by amalgamated sandstone complexes with abundant channel scour surfaces. The migration of the rollover anticline towards the breakaway of the principal basin-bounding fault resulted in the footwall-directed migration of facies belts upwards in the stratigraphy. In our interpretation, a kilometresthick, footwall-skewed amalgamated sandstone complex was constructed that marks the trace of the migrating rollover anticline through the basin stratigraphy. On the basis of stacking patterns of marginal facies, large-scale grain-size variations, the geometry of stratigraphic units and the overall lithofacies distribution, we present a sequence stratigraphic model for the basin fill. Within individual systems tracts, lithofacies distribution as well as inferred A/S ratios vary laterally because of the effects of differential subsidence and multidirectional sediment transport. Inferences of A/S ratio from vertical sections in one particular part of the basin thus cannot be used to characterize a systems tract as such. Grain-size turnarounds may, however, be used in the definition of systems tracts and sequences if the above relationships are well constrained and if turnarounds occur in stratigraphic units that are easy to correlate across the basin.
Associations between High Protein Intake, Linear Growth, and Stunting in Children and Adolescents: A Cross-Sectional Study

Background and aims: Childhood and adolescence are critical periods for linear growth and preventing stunting. Current evidence indicates that dietary protein intake in children and adolescents is often two to three times higher than the recommendations in many regions worldwide. However, few studies have focused on the association between high protein intake and linear growth and stunting in this population. We aim to investigate this association in children and adolescents aged 6 to 18 years in a population with relatively high protein consumption. Methods: We conducted a large cross-sectional study involving 3299 participants from Shenzhen, a modern metropolis of China. Protein intake, including total protein, animal protein, and plant protein, was evaluated by a food-frequency questionnaire and expressed as grams per kilogram of body weight per day (g·kg−1·d−1) and as a percentage of total energy intake (%E). The primary outcomes were body height and height-for-age Z score (HAZ). Generalized linear models and logistic regression analyses were employed to examine the associations between protein intake and outcomes. We also conducted stratified analyses across different genders and pubertal stages in the aforementioned associations. Results: The mean protein intake was 1.81 g·kg−1·d−1 (17% E). After adjusting for serum calcium, zinc, vitamin D3, vitamin A levels, birth outcomes, lifestyle, and parental characteristics, each standard deviation increase of 1 in protein intake (0.64 kg−1·d−1) is found to be associated with a −5.78 cm change in body height (95% CI: −6.12, −5.45) and a −0.79 change in HAZ (95% CI: −0.84, −0.74). Consistent results were observed when protein intake was expressed as %E or specifically as animal or plant protein. Moreover, the relationship between protein intake and linear growth remained consistent across genders in different pubertal stages, similar to that of the overall participants. Conclusions: Our findings highlight the potential hazards of high protein intake on linear growth in children and adolescents. Caution should be exercised when promoting increased protein consumption in children and adolescents who already have a high intake of protein.
The Influence of Product Reviews, Prices and Trust on Online Purchase Decisions at Shopee

The digital industry in Indonesia is growing and increasing very rapidly, one of the growing industries is the e-commerce industry in Indonesia. Trust, researchers conducted research on Shopee. So this research is entitled "The Influence of Product Reviews, Prices and Trust on Online Purchasing Decisions on Shopee In Bandung". In this study, the population consisted of customers in Bandung who had used the Shopee program for online shopping and the exact number was not known. The sample technique used is purposive sampling, with respondents consisting of Bandung residents who have used the Shopee program at least three times for online purchases. This research was conducted in Bandung. The investigation stage lasted for six months. There are independent factors and dependent variables in this study. Product reviews, cost and trust are independent factors. Whereas the bound variable is the option to buy. According to the research findings, product reviews do not affect purchasing decisions on Shopee. Shopee buyers are affected by the price when making a purchase. Shopee's purchasing decisions are influenced by consumer trust, Product Reviews, Pricing, and Trust all have an effect on the Purchase Decision.
Stochastic dominance-based comparison between iterative improvement and simulated annealing algorithms for minimum losses distribution systems reconfiguration

: This paper presents a comparison between two different techniques used for solving the distribution systems reconfiguration problem with the aim of minimizing the power losses. The solution methods considered are the iterative improvement algorithm and the simulated annealing algorithm. The methods are applied to a reconfigurable distribution system considering the radiality and operational constraints. The comparison is carried out by resorting to a proposed variant of an indicator based on the first-order stochastic dominance.