Miracle-dz/UniFAR-FTUs huggingface dataset:
Effect of Endophytic Bacteria Burkholderia cepacia on Growth, Cocoon Characters and Enzyme Activity of Silkworm, Bombyx mori L.

Microorganisms have always been of scientific prominence and their indulgence in industrial and research facets cannot be denied. Several microorganisms have been employed as research tool to amend various parameters of industrial prominence. The current research article is from the context of significance emphasizing on the silk industry. The research article has focused on the impact of Burkholderia cepacia which is an endophytic bacterium on the silk worm and the affirmative aspects were recorded. The research work included the inoculation of the bacterium with the silk worm which has resulted in enhanced production of silk from the inoculated lot. In addition, the research has also demonstrated higher activity of protease and amylase in inoculated lot when compared to control population. The results obtained have substantiated the practical aspect of the research. Original Research Article Gunasekhar and Somayaji; SAJRM, 5(4): 1-8, 2019; Article no.SAJRM. 54328 2
Blood Pressure Percentiles for School Children

Objective: The prevalence of hypertension in childhood and adolescence is gradually increasing. We aimed to investigate the blood pressure (BP) values of children aged 7-18 years. Methods: This study was conducted in a total of 3375 (1777 females, 1598 males) children from 27 schools. Blood pressures of children were measured using sphygmomanometer appropriate to arm circumference. Results: A positive relationship was found between systolic blood pressure (SBP) and diastolic blood pressure (DBP) and the body weight, height, age and body mass index (BMI) in male and female children. SBP was higher in males than females after the age of 13. DBP was higher in males than the females after the age of 14. The mean annual increase of SBP was 2.06 mmHg in males and 1.54 mmHg in females. The mean annual increase of DBP was 1.52 mmHg in males and 1.38 mmHg in females. Conclusion: In this study, we identified the threshold values for blood pressure in children between the age of 7 and 18 years in Erzurum province. It is necessary to combine and evaluate data obtained from various regions for the identification of BP percentiles according to the age, gender and height percentiles of Turkish children.
The Effect of Family Psychoeducation on Burden of Care in Families with Type I Diabetic Children

Background: When controlling diabetes in children, families suﬀer from burden of care imposed by the disease. The aim of this study was to investigate the eﬀect of family psychoeducation on the burden of care imposed on families of adolescents with type 1 diabetes referring to Golestan diabetes clinic in Ahvaz city. Methods: The present study was a clinical trial with before-after design. The study population included families with adolescents with type 1 diabetes aged 12 - 19 years. A total of 40 families of sick children and one parent who was more in touch with the patient were selected and randomly divided into experimental (20 families) and control groups (20 families). To measure family burden of care, burden of care Questionnaire (DFI-S) was used. Family psychoeducation was carried out for the experimental group twice a week for 8 sessions of 90 minutes. Independent and paired t-test and Mann-Whitney test were used to compare the mean score of familyburdenof careinbothgroupswhileChi-squaretestwasusedtocomparequalitativevariablesbetweenthetwogroups. SPSS v. 20 was used for statistical analysis. Results: The most frequent age range of diabetic children was 12 - 14 years (55%) and 15 - 19 years in the experimental and control groups(65%),respectively. Mostfathersandmotherswereself-employed(60%)andhomemakers(85%),respectively. Themeanscore of burden of care imposed on families before the intervention in the experimental and control groups was 26.6 and 30.15, respec-tively, that reduced to 21.6 and 30.35 three months after the intervention, respectively, showing no change. Conclusions: Familypsychoeducationcanreducefamilyburdenof careimposedbyadolescentssuﬀeringfromtypeIdiabetesand increase the period for families facing the disease. It also reduces medical treatment costs and length of stay in health centers and increases quality of home care.
Succinylcholine-induced Increases in Plaima Catecholamine Levels in Humans

of the Ohio anesthesia ventilator warn us of a disconnection. The fresh gas flow tubing is too small to allow a sufficiently large leak to trigger the low pressure alarm. In addition, the weighted bellows entrains sufficient room air through the fresh gas tubing to replace any volume lost from the circuit secondary to the leak. Recently, Dorsch and Dorsch (2) recommended the routine use of an oxygen analyzer in every case. Our cases reinforce this recommendation by providing another reason for the use of an oxygen monitor. The oxygen analyzer can aid in the discovery of disconnections that the low pressure alarm of the ventilator cannot detect.
Cu-DOTATATE PET / MRI for Detection of Activated Macrophages in Carotid Atherosclerotic Plaques Studies in Patients Undergoing Endarterectomy

Carotid atherosclerosis is a major risk factor of stroke and transient ischemic attack. Randomized trials have shown that carotid endarterectomy significantly reduces the risk of recurrent stroke in patients with recent symptoms of transient ischemic attack or stroke and at least 50% stenosis of the relevant carotid artery. However, not all patients will benefit from the surgery because some will have stable plaques that are not prone to cause new thromboembolic lesions. In addition, many patients without significant carotid stenosis will experience recurrent stroke and could have benefited from endarterectomy. A quest for new and more sensitive methods for in vivo identification of vulnerable atherosclerotic plaques is needed. Positron emission tomography (PET) for molecular imaging, typically in conjunction with anatomic imaging with computed tomography (CT), is one promising hybrid modality. The molecular tracer of choice has to date primarily been 2-[F]-fluoro-2-deoxy-D-glucose (FDG). FDG is a glucose
Forefoot disorders: definitions, treatment and outcome measurement

The found prevalence of foot pain in the adult general population ranges from 22% to 25%. Foot pain may impair mobility and decrease the sense of well-being. A variety of different disorders may result in foot pain. This thesis describes several causes of forefoot pain, with results of clinical studies focusing on specific treatment of these causes. Specifically lesser toe deformities and rheumatoid forefoot deformity are evaluated. From here, general recommendations on definitions and treatment of these disorders are described. The main conclusion of this thesis is that limited scientific knowledge on forefoot problems exists. Despite the high prevalence of these problems, limited scientific studies, directed on this topic, are performed. These problems are often underestimated and thus inadequately treated. It is expected forefoot related problems will rise, due to ageing, insufficient footwear and sports activities. Increase of specific studies, with increase of knowledge, should lead to higher quality of care of this patient population.
Concealed Illegal Drugs: An Actual Cause of Airway Obstruction

We would like to share with you an interesting case of a POtentially difficult airway. A lCyr-old, 70-kg girl with vaginal condylomata was scheduled as an outpatient for laser excision. She had no other medical problems, and upon examination of the oral airway, it was noted that she had full mouth braces, and attached to her lower teeth across the floor of the mouth was an orthodontic appliance (Figure 1) inserted to prevent thumb sucking. It was shaped like an arched gate, permanently adherent and could only be removed by a dentist. Her soft palate could be visualized, but not her tonsillar pillars or posterior pharynx, thus making her a Mallampati Class I11 (1). The anesthetic options of regional versus general with an awake endotracheal intubation were presented to the patient and her parents. They refused regional anesthesia. The patient was sedated with midazolam and alfentanil. Benzocaine and lidocaine were applied topically to the oropharynx and her right nares was prepared using phenylephrine and lidocaine. Endotracheal intubation was attempted using a nasal fiberoptic technique, but the endotracheal tube was ultimately passed blindly. After inducing general anesthesia, oral laryngoscopy was performed. Visualization of the vocal cords was possible only if the laryngoscope was positioned on the right side of the mouth. Because surprises (like this dental appliance) can occur, the airway must always be thoroughly assessed before planned intubation. With the burgeoning use of outpatient surgery, unexpected airway abnormalities will still be encountered. Therefore, it is important to always remember these tenets: (a) "Don't forget the basics," (b) "Don't burn any bridges," and tc) "Do no harm. " Mary Ann Gurkowski, MD Kelly Gordon Knape, MD Christopher A. Bracken, MD University of Texas Health Science Center at Sun Antonio Department of Anesthesiology Sun Antonio, T X 78284-7838 Concealed Illegal Drugs: An Actual Cause of Airway Obstruction
Phenylephrine Does Not Reduce Cerebral Perfusion Canine Cardiopulmonary Bypass

Gaseous microemboli during cardiopulmonary bypass (CPB) could injure the blood-brain barrier so that cerebral vasoconstriction would result from infusing a-agonist drugs, such as phenylephrine. Cerebral blood flow (radioactive microspheres) and metabolism were measured in seven dogs after rewarming from 150 min hypothermic CPB with bubble oxygenators used to produce gaseous microemboli. Phenylephrine (40 pg/min) was infused directly into the brachiocephalic artery so that aortic pressure before (80 ? 2 mm Hg) and during (79 2 3 mm Hg) the infusion did not change. Neither blood flow to the cerebral hemispheres (P = 0.960), cerebellum (P = 0.8541, and brainstem ( P = 0.694) nor the cerebral metabolic rate for oxygen ( P = 0.862) differed when values obtained before and after 30 min of phenylephrine infusion were compared. Cerebral vascular resistance was also unchanged by phenylephrine, being 1.22 -C 0.10mmHg~mL~'~min-'~100g-' before infusion and 1.25 2 0.17 mm Hg.mL-'. min-'. lOO g-' during infusion (P = 0.849). Phenylephrine does not cause cerebral vasoconstriction after rewarming from hypothermic CPB, a finding which suggests that the blood-brain barrier is preserved during bypass. (Anesth Analg 1994;79:14-8)
A SCORING MODEL FOR RISK CHARACTERISATION AND SETTING PRIORITIES IN VETERINARY PUBLIC HEALTH

A model for prioritization and risk characterization focused on zoonosis and food safety was developed for diseases of interest in veterinary public health at a regional level. A previous model (DISCONTOOLS) based on scorecards was used as a basis to develop the new one . Formalized Consensus Process approach involving academics and veterinary officers was used to develop form, scorecards and relative guide. Scorecards were filled following available data, literature and expert opinions. A scorecard with maximum theoretical score of 1,000 was developed; it includes several areas of interest, with different categories and coefficient of importance. The following areas were identified: relevance of the disease, socio-economic impact, impact on public health, impact on trade, impact on animal welfare, control tools. A guide and a form were settled in order to fill the scorecard. From an initial list of 38 disease, 23 were scored. Among bovine diseases mastitis (S. aureus) showed the highest score; among small ruminants Query fever was the highest, among swine diseases the highest was salmonellosis, while among other animal diseases toxoplasmosis had the highest score. This approach is conceived to aid professionals in risk prioritization, decision-making and to improve disease control systems at a regional level. It also allows to perform risk characterization in different backgrounds and to identify lacks of data in specific areas of interest for the diseases
The Combination of Tramadol and Morphine May Be Recommended for Postoperative Analgesia

(Fig. 2). After the operation, neurological examination showed a significant improvement and revealed a partial brown squared syndrome. Urinary and anal incontinence were also recorded. Six weeks later, the patient left the hospital. However, 3 mo later the patient died from bowel perforation and respiratory failure. The present report agrees with the previous report of Fujioka et al. (1), who speculated that placing the neck in an extended position during surgery might aggravate a preexisting spinal canal stenosis, resulting in cervical cord injury. Also, this report suggests that we should avoid extending the neck in patients with a preoperative diagnosis of cervical spine stenosis and that the neck should be manipulated similarly to manipulation of patients with cervical spine fracture. Also, preoperative screening for cervical spine stenosis is advised for elderly patients in whom an extended position of the neck is required.
Nebulization of Lidocaine with Varied Oxygen Flow Rates

We thank Drs. Michaloudis and Kanoupakis for their comments on our manuscript (1). In this study, we had prospectively compared the effects of three general anesthetics and the combination of local anesthesia plus propofol on the minimal energy requirement of an implantable cardioverter defibrillator (ICD) during its insertion. It was not our intention to examine the effect of propofol on the QT interval; rather, we cited the two cases that were reported by Michaloudis et al. (2), in which they demonstrated that the QT interval may be shortened after the administration of propofol. On the basis of the findings they describe in this case report, the differences in the QTc appear not to be of significant value. We believe that their report as well as those of others contribute to the validation of our conclusion that propofol is safe even in patients with severe cardiac dysfunction and electrophysiological disturbances. The results and conclusion of our study, that propofol was a safe and an applicable mode of anesthesia for a group of high-risk patients requiring the implantation of ICD, were the same as theirs (2).
Does Combined Spinal-Epidural Analgesia Alter the Incidence of Paresthesia During Epidural Catheter Placement ?

We appreciate Frizelle and Moriarty’s interest in our article (1) comparing a conventional axillary block and a new approach at the midhumeral level. It is encouraging to observe that they share our enthusiasm regarding this new approach. However, we would like to stress the fact that a comparison between the success rate reported by Lavoie et al. (94%) (2) and ours (54%) is not conceivable. Indeed, Lavoie et al. considered a block to be successful when the dermatomes of the nerves implicated in the surgical site were anesthetized, whereas we required that all dermatomes of the upper extremity be anesthetized. In both studies, the definition of success does not rely on the method used to assess the sensory block, as suggested by Frizelle and Moriarty. In the study of Baranowski et al. (3), there was only a nonsignificant trend toward a positive relationship between the number of nerves located by a nerve stimulator and the success rate. We, as others (4,5), found that the more nerves located, the higher the success rate of the block (87% vs 54%; four versus two nerves located in our study). The reason we compared the midhumeral approach (four stimulations) with the axillary approach (two stimulations) rather than four versus two stimulations in the axillary crease, has already been discussed in the article. Finally, we agree with Frizelle and Moriarty that technical pearls already exist with this new technique (6) and are useful improvements. The technique was named midhumeral because its first description in an American meeting (American Society of Regional Anesthesia, 1996) (7) used this term. We agree, however, that this technique would be better named the brachial or humeral canal approach in future publications.
CAPTURING TEACHER BASIC NEEDS SATISFACTION: VALIDATION EVIDENCE FOR THE GREEK SCALE MEASURING PE TEACHERS’ BNS

According to self-determination theory, teachers’ basic needs satisfaction is essential for the quality of their motivation, teaching, and work behavior. Considering the lack of valid and reliable instruments measuring teachers’ basic needs satisfaction (for autonomy, competence and relatedness) within the Greek context, we evaluated the factorial validity and internal consistency for the Greek version of the Basic Needs Satisfaction Scale for Teachers (BNSST; Longo et al., 2016). Standard back-translation procedures were followed. Focusing on Physical Education (PE) teachers, the validity of the measure was evaluated via two cross-sectional studies with samples of pre-service (n=109; study 1) and in-service (n=91; study 2) teachers. The psychometric properties of the instrument were established through exploratory and confirmatory factor analysis, Cronbach’s alphas, and latent variables’ associations with external criteria. In both studies, factor analyses results supported the construct validity of the 9-item, 3-correlated factors model, producing satisfactory goodness of fit indices, suggesting that the three needs are positively related with each other. Internal consistency analysis produced acceptable values for all the scales of the study. In line with theoretical assumptions and past research evidence, latent variables correlations with external criteria showed that basic needs satisfaction connects positively with their beneficence, cooperation willingness, intrinsic motivation and identified regulation. Furthermore, structural equation modeling revealed a positive connection between teachers’ general basic needs satisfaction and their autonomous motivation, work engagement, and work satisfaction, suggesting that the fulfillment of teacher basic needs can positively predict their well-being at work. The present findings suggest that the BNSST-GR has good psychometric properties and provide initial support for the instruments’ validity and reliability. Such measurements may prove useful in examining Greek teachers’ basic needs satisfaction in a variety of work-related contexts (e.g., teacher professional development). Article visualizations:
Associating retinal drug exposure and retention with the ocular toxicity profiles of Hsp90 inhibitors.

3086 Background: In clinical trials certain Hsp90 inhibitors, including AUY922, SNX-5422, and 17-DMAG have caused visual symptoms suggesting retinal dysfunction; others, including ganetespib and 17-AAG, have not. Previous animal toxicology experiments have suggested that retinal changes may be linked to photoreceptor degeneration or cell death. Here histopathologic changes and/or exposure profiles of Hsp90 inhibitors with or without clinical reports of ocular toxicity were evaluated to understand the observed differences in toxicity profile between agents in this class. Methods: We reviewed visual symptoms among subjects administered ganetespib, a potent Hsp90 inhibitor currently in phase II trials; evaluated retinal morphology in rats and cyno monkeys given ganetespib; and compared TUNEL-positive photoreceptors and drug exposure profiles in the retina of rats treated with AUY922, 17-DMAG, and 17-AAG. Studies of ganetespib’s retinal pharmacokinetics and photoreceptor toxicity in rats are ongoing. Results:.
Association of Human Papillomavirus Type 16 Long Control Region Variations with Cervical Cancer in a Han Chinese Population

Objective: High-risk human papillomavirus (HPV) E6 and E7 proteins are the major oncoproteins involved in the tumorigenesis of cervical cancer. The long control region (LCR) in HPV plays an important role in regulating the expression of the E6 and E7 oncogenes. In the current study, we investigated the association of HPV16 LCR variations with cervical cancer. Methods: A total of 139 HPV16-positive cervical cancer patients (case group) and 116 HPV16-positive asymptomatic individuals (control group) were enrolled in the current study. Then, the HPV16 LCR was sequenced to determine the association between LCR variations and cervical cancer. Results: In the current study, HPV16 A1-A3 (19.4%), A4 (78.4%) and D3 (2.2%) variants were found in the case group. However, only A1-A3 (34.5%) and A4 variants (65.5%) were found in the control group. The distribution of the HPV16 variants between the case and control groups was significantly different (P=0.009). Moreover, a total of eleven variations (A7167G, A7173C, C7176T, C7200T, T7269C, C7286A, C7729A, C7763T, A7841G, G7867A and T24C) were significantly different between the case and control groups (P<0.05). For the sub-lineage analysis, only C7873G variations were significantly different between the case and control groups in the A4 (As) variant (P=0.039). Conclusion: Our results showed that specific variations in the HPV16 LCR were associated with cervical cancer. Our study will provide a good reference for further understanding of the relationship between HPV16 LCR variation and cervical cancer.
A THEORETICAL STUDY TO PREDICT THE YOUNG’S MODULUS OF ZIGZAG SINGLE WALLED CARBON NANOTUBES CONTAINING VACANCIES

An analytical molecular structural mechanics model is developed for the prediction of Young’s modulus of zigzag single walled carbon nanotubes with single vacancies by combining continuum mechanics with modified Morse potential function under tensile loading. Defects, especially vacancies, cause a remarkable change in the Young’s modulus, especially when they are numerous. Effects of defect concentration in the axial direction (length of defective section(s) /total length of the tube) and defect concentration in the transverse direction (number of vacancies in circumference) on Young’s modulus have been studied. Defective CNTs have smaller moduli than an intact CNT, but by increasing diameter the effect of defects is decreased and modulus of defective CNTs approaches that of an intact CNT.
CYTOTOXIC EFFECT OF HYDROALCOHOLIC EXTRACT OF CORNUS MAS L.FRUIT ON MCF7, HEPG2 AND CHO CELL LINE BY MTTASSAY

Background and purpose: Today cancer is considered as one of the leading causes of death worldwide. An impressive number of modern drugs used in cancer treatment are isolated or derived from natural sources based on their use in traditional medicine. Cornus mas L. (Cornaceae) has medicinal applications in treating a wide range of diseases such as cancer. This study was designed to evaluate the Cytotoxic effect of Cornus mas L.fruit hydroalcoholic extract on normal and cancer cell lines. Material and Methods: Rip fruit and unripe fruit extract was prepared by soxhlet extraction method. The anticancer activity of different concentrations of the extract (0, 10, 50, 100, 150, 200, 250µg/ml) in three cell lines MCF7 (breast cancer), HepG2 (liver cancer), and CHO (normal hamster ovary) were examined using MTT. Statistical analysis was performed using SPSS V.16. Results: The findings revealed time and dose-dependent inhibition and also significant differences between the levels of IC50 of unripe and ripe fruit in all cell lines (P<0.05). Also, the level of IC50 of unripe and ripe fruit on normal cell lines was significantly different from that of the cancer cell lines (P<0.05). However, cytotoxicity of unripe fruit was found more than ripe fruit. Conclusion: This study showed that hydroalcoholic extract of Cornus mas L. (unripe and ripe), have a considerable cytotoxic effect on cancer and normal cell lines and should be further investigated to find effective compounds present in the fruit extract. Hence, effective steps could be taken towards finding new drugs in treating cancer.