Miracle-dz/UniFAR-FTUs huggingface dataset:
Targeting STAT3 Signaling in COL1+ Fibroblasts Controls Colitis-Associated Cancer in Mice

Simple Summary Colitis-associated cancer is a colorectal cancer entity with poor prognosis and limited therapeutic options typically occurring as long-term complications of inflammatory bowel diseases. Connective tissue cells such as cancer-associated fibroblasts are part of the tumor microenvironment that can influence cancer development. The aim of this study was to determine the role of STAT3 activation in a frequent subset of fibroblasts during the development of inflammation-associated colorectal cancer in vivo. Our work highlights the functional role of cancer-associated fibroblasts in colitis-associated cancer, suggesting that strategies targeting the activation of that cell type could evolve as promising therapeutic option in inflammation-associated colorectal cancer and possibly additional entities. Abstract Colorectal cancer (CRC) is a common disease and has limited treatment options. The importance of cancer-associated fibroblasts (CAFs) within the tumor microenvironment (TME) in CRC has been increasingly recognized. However, the role of CAF subsets in CRC is hardly understood and opposing functions of type I (COL1+) vs. type VI (COL6+) collagen-expressing subsets were reported before with respect to NFκB-related signaling. Here, we have focused on COL1+ fibroblasts, which represent a frequent CAF population in CRC and studied their role upon STAT3 activation in vivo. Using a dual strategy with a conditional gain-of-function and a conditional loss-of-function approach in an in vivo model of colitis-associated cancer, tumor development was evaluated by different readouts, including advanced imaging methodologies, e.g., light sheet microscopy and CT-scan. Our data demonstrate that the inhibition of STAT3 activation in COL1+ fibroblasts reduces tumor burden, whereas the constitutive activation of STAT3 promotes the development of inflammation-driven CRC. In addition, our work characterizes the co-expression and distribution of type I and type VI collagen by CAFs in inflammation-associated colorectal cancer using reporter mice. This work indicates a critical contribution of STAT3 signaling in COL1+ CAFs, suggesting that the blockade of STAT3 activation in type I collagen-expressing fibroblasts could serve as promising therapeutic targets in colitis-associated CRC. In combination with previous work by others and us, our current findings highlight the context-dependent roles of COL1+ CAFs and COL6+ CAFs that might be variable according to the specific pathway activated.
Analysis and Design of a Two-Phase Series Capacitor Dual-Path Hybrid DC-DC Converter

Inthis article, a two-phase series capacitor dual-path hybrid dc–dc converter with the step-down ratio of less than 1/6 is proposed for the first time. In this converter, the output current is divided into capacitance- and inductance-path, so the average value and ripple of inductance current are reduced. On the same time, the conduction loss caused by inductance equivalent series resistance (ESR) is also reduced. The addition of series capacitor leads to desirable characteristics, including lower switching stress, switching loss, parasitic output capacitance loss on mosfet, automatic phase current balancing, duty ratio extension, etc. A 120 W prototype has been designed to demonstrate theoretical analysis. Obtained efficiency was up to 93.18% at full load. Experimental results show good agreement with theoretical analysis and high feasibility of proposed converters.
Variations and Arguments of Anti-Vaccine Movement Groups on Facebook

This study examined a social movement in the digitalized world along with its role in the public policy process. The research focused on how the social movement was accessed and spread, and how knowledge was formed on Facebook so that it could influence the success or failure of a certain policy. It is essential to further explore how knowledge is mobilized through social movements in the digitalized world so as to enrich the theories of governance and public policies. In this study, content analysis was ued. The results showed that the group of main actors who criticized the vaccine’s safety was heterogeneous. In terms of vaccine criticism, there were the anti-vaccine movements, the marginally anti-vaccine movements, and the occasionally vaccine-critical movements. This heterogeneity could be found in the type of arguments mobilized to question the vaccine’s safety and in these actors’ likelihood of being involved in any vaccine-related controversies. The religion and conspiracy theory discourses were the two most used discourses to reject the vaccine delivery program in Indonesia. By mobilizing knowledge through a social movement in the digitalized world, the anti-vaccine movement actors had a wider network and had the potential to influence the success of the government program. Keywords: social movement, anti-vaccine, health policy, social media
Uncovering Typologies of Civically Engaged Latina/o College Graduates at 4-Year Institutions of Higher Education

ABSTRACT This study sought to examine how Latina/o1 college graduates engage civically. Through a four-step quantitative design, we found that Latina/o college graduates vote, volunteer, advocate, donate money, serve as cultural and political resources, and run for elected office. We also identified five typologies, or classes, of civically engaged Latina/o college graduates: Activistas, Mentores, Politicos, Votantes, and Indiferentes. Implications for practice and future research are discussed.
Adaptasi dan properti psikometri Parental Stress Scale versi Bahasa Indonesia

Stres pengasuhan adalah ketegangan yang dialami orang tua terkait peran pengasuhan. Parental Stress Scale (PSS) merupakan instrumen yang telah banyak digunakan untuk mengukur stres pengasuhan yang dialami orang tua. Sejumlah studi di beberapa negara telah berusaha mengungkap validitas konstruk dan reliabilitas dari PSS. Penelitian ini bertujuan untuk menguji properti psikometri Skala Stres Pengasuhan (SSP) yang merupakan adaptasi PSS dengan mengombinasikan pendekatan Analisis Faktor Eksploratori (EFA) dan Analisis Faktor Konfirmatori (CFA). Penelitian ini melibatkan 449 orang tua, khususnya ibu di Indonesia yang memiliki anak berusia 3-12 tahun. Sampel dalam penelitian ini dibagi menjadi dua kelompok sampel secara acak, di mana analisis EFA dilakukan pada kelompok sampel pertama (N = 249) dan analisis CFA dilakukan pada kelompok sampel kedua (N = 200). Hasil analisis statistik menunjukkan struktur dua dimensi dari 15 butir SSP memiliki properti psikometri yang memuaskan.
Global sanctions, foreign direct investment, and global linkages: evidence from global data

Using a rich and updated dataset on the Global Sanction Data Base (Felbermayr et al. “The Global Sanctions Data Base,” European Economic Review 2020; 129: 1–23), this study examines the effect of sanctions on FDI flows across 1,717 pairs of 66 countries during the 2000–2012 period and the role played by international linkages such as global value chains and global bank linkages in the sanction-FDI nexus. Results from the gravity model show that sanctions indeed have heterogenous effects on FDI flows when separate types of sanctions are put into consideration. They significantly reduce FDI flows in the pre- and during the crisis period. Both global value chains (GVCs) and global bank linkages (GBLs) play a moderating role in the sanction-FDI nexus, where the consequences of sanctions on FDI flows become more severe in the presence of these two types of international linkages. It is also found that GVCs signify the negative impacts of trade sanctions, while the GBLs can be regarded as a channel through which financial sanctions affect FDI flows more significantly. These findings bridge two strands of literature on sanctions and international linkages, where the latter is on the rise due to the worldwide presence of multinational corporations’ activities and the globalization of the financial markets.
Urinary Phthalate Biomarkers during Pregnancy, and Maternal Endocrine Parameters in Association with Anthropometric Parameters of Newborns

Adverse birth outcomes present risk factors resulting in neonatal morbidity and mortality. Sufficient maternal hormonal concentrations are crucial for normal foetal development. Previous studies have shown a relationship between phthalate exposure and maternal hormonal levels during pregnancy. This study aims to investigate if neonatal anthropometric parameters are associated with maternal endocrine parameters during the ≤15th week of gestation and the third trimester of pregnancy concerning phthalate exposure in pregnant women from Nitra, Slovakia. We used high-performance liquid chromatography, tandem mass spectrometry (HPLC-MS/MS), and electro-chemiluminescence immunoassay to quantify urinary concentrations of phthalates and serum concentrations of hormones and sex hormone-binding globulin (SHBG), respectively. We observed a mostly positive correlation between neonatal anthropometric parameters (gestational age, birth length, birth weight, head circumference) and maternal concentration of phthalate metabolites (p ≤ 0.05). The hierarchical multivariate regression results showed a statistically significant association between Apgar score at 5 min after delivery, gestational age, birth weight, head circumference, and maternal endocrine parameters during pregnancy (p ≤ 0.05), adjusted to phthalate metabolites. To the best of our knowledge, our study is the first to indicate that prenatal exposure to phthalates may also affect birth outcomes through interaction with the maternal endocrine system.
The complete mitochondrial genome of the Amur soft-shelled turtle (Pelodiscus maackii Brandt, 1858), from South Korea

Abstract In this study, we use a specimen from wild-caught individual to determine the complete mitochondrial genome of the Amur soft-shelled turtle (Pelodiscus maackii). The complete mitogenome of P. maackii has 16,258 bp in length and consists of 13 protein-coding genes (PCGs), 22 tRNAs, two rRNAs, and one control region. The arrangement of genes of P. maackii is identical with previously reported mitogenomes in the family Trionychoidea. According to our result, the ML tree for the phylogenetic reconstruction revealed that the individuals used in present study is closely related with the previously reported sequences of P. sinensis (AY962573 and MG431983) in p-distance 0.7% and 2.5%.
Sustainable practices in hospitality pre and amid COVID‐19 pandemic: Looking back for moving forward post‐COVID‐19

Abstract Sustainability issues are becoming increasingly important in the hospitality sector during crisis times such as COVID‐19 and post‐pandemic. In order to synthesize the literature on sustainable practices in hospitality, we developed a systematic literature to illustrate the dominant sustainable practices in hospitality. We present a comprehensive review of the 48 articles on sustainable practices in hospitality through the Web of Science (WoS) and Scopus databases; spanning over 2 years (2020–2021) pre‐and amid the COVID‐19 pandemic and extending the scope in distinctive ways. Our review has demonstrated that sustainable practices in hospitality have made progress in the years 2020 and 2021. However, there are conceptual and empirical overlaps among sustainable practices in hospitality. Additionally, hospitality sustainable practices research is restricted in research contexts. There is a lack of research on antecedents, outcomes, and integrating theories in studies. By following the guidance presented in this review, we expect to advance and maintain sustainable practices research to provide substantive insights over the coming years post‐COVID‐19. The current research is one of the first studies to systematically review sustainable practices in hospitality pre‐and amid the COVID‐19 pandemic. The research ends with a comprehensive research agenda and a framework to apprise future theoretical and empirical advances in the area.
Current Practice of High Flow through Nasal Cannula in Exacerbated COPD Patients

Acute Exacerbation of Chronic Obstructive Pulmonary Disease is a form of severe Acute Respiratory Failure (ARF) requiring Conventional Oxygen Therapy (COT) in the case of absence of acidosis or the application of Non-Invasive Ventilation (NIV) in case of respiratory acidosis. In the last decade, High Flow through Nasal Cannula (HFNC) has been increasingly used, mainly in patients with hypoxemic ARF. However, some studies were also published in AECOPD patients, and some evidence emerged. In this review, after describing the mechanism underlying potential clinical benefits, we analyzed the possible clinical application of HFNC to AECOPD patients. In the case of respiratory acidosis, the gold-standard treatment remains NIV, supported by strong evidence in favor. However, HFNC may be considered as an alternative to NIV if the latter fails for intolerance. HFNC should also be considered and preferred to COT at NIV breaks and weaning. Finally, HFNC should also be preferred to COT as first-line oxygen treatment in AECOPD patients without respiratory acidosis.
Barriers of environmental management accounting practices in developing country

The use of environmental management accounting (EMA) benefits organisations by providing them with different information for decision-making (Burritt, Hahn, & Schaltegger, 2002; Adams & Zutshi, 2004; International Federation of Accountants IFAC, 2005). EMA has received increasing attention since 2000 and is now considered an effective tool for dealing with environmental issues and the economic performance of companies and countries (Elhossade, Abdo, & Mas’ud, 2021). This paper purposes to present an empirical case for research in EMA. The paper provides an analysis of the current status of EMA practices in manufacturing companies operating in Libya and identified the barriers preventing such practices. Data were collected from a sample of companies in Libyan manufacturing industry contexts utilizing a questionnaire survey. To analyse these data, two statistical techniques were employed: factor analysis and descriptive tools analysis. The current level of EMA adoption among manufacturing companies in Libya was found to be low. The findings of the study reveal that institutional barriers constituted the greatest obstacle to the adoption of EMA in manufacturing companies in Libya. This was followed by management barriers, informational barriers, financial barriers, and, lastly, attitudinal barriers. This paper concluded that Libyan universities should include EMA in the management accounting syllabus, provide books, and conduct research into practices related to EMA. Furthermore, the Libyan government and other stakeholders should play an active role in enacting and enforcing further strict environmental regulations and laws. This would be useful, as it would increase the concern of local communities about environmental issues; this would, in turn, make companies more concerned about improving their environmental performance.
Dynamic Psychotherapy as a PTSD Treatment for Firefighters: A Case Study

In Portugal, forest fires are responsible for disasters that tend to be repeated annually, leading to dramatic consequences, such as those that have occurred in 2017, with the destruction of hundreds of houses and the deaths of dozens of people. Firefighters who are exposed to these potentially traumatic events are considered a high-risk group for the development of stress-related disorders. The aim of this study was to monitor the progress of two firefighters with symptoms of post-traumatic stress disorder (PTSD) treated through dynamic psychotherapy (DP) and to assess the feasibility of implementing this intervention within fire departments. A female firefighter and a male firefighter, with similar sociodemographic characteristics and PTSD symptom severity, were selected to verify the treatment applicability for both genders. The symptomatology changes were assessed through a set of instruments (PHQ-15, PCL-5, BSI, DASS, and CALPAS-P) applied every three months over 15 months (including pre-treatment, treatment period, and post-treatment). DP seemed to be an effective treatment for PTSD symptoms, with patients showing a state of increasing improvement even after the end of treatment. The acceptability to firefighters, the treatment adherence, the therapeutic alliance, and the reduction in PTSD symptoms suggest feasibility for implementing this intervention inside the Portuguese fire departments.
Prosopis farcta: Potent Antifungal Activity Against Trichophyton mentagrophytes Strains; A Research Based on an Ethnobotanical Study

Background and Aim: Dermatophytosis is a superficial fungal disease. Prosopis farcta has attracted attention for ethnobotany and medical purposes. The present study aimed to investigate the antifungal properties of Prosopis farcta extracts against Trichophyton mentagrophytes (PTCC 5054) and five archived terbinafine resistant clinical isolates of T. mentagrophyte, based on an ethnobotanical report in Yazd province (Iran). Materials and Methods: In vitro drug susceptibility for methanol extract and amphotericin B was carried out according to the CLSI-M38-A2. A topical solution (1%) was formulated by root extract of P. farcta. The nine male Sprague rats were infected by T. mentagrophytes and assessed for in vivo anti-dermatophytic activity. Results: The MIC value of amphotericin B was ≤ 0.5 μg/mL against all strains. The methanol extract showed the lowest MIC and MFC values on fungal activity (both with 0.00625 mg/mL). The complete cure of 21-day period with terbinafine is reduced to 10 days with methanol 80% root extract of P. farcta solution. Conclusion: Compared with amphotericin B, P. farcta could be considered a potential antifungal agent in terbinafineresistant clinical isolates of dermatophytes.
Incremental Bayesian segmentation for intrusion detection

This thesis describes an attempt to monitor patterns of system calls generated by a Unix host in order to detect potential intrusion attacks. Sequences of system calls generated by privileged processes are analyzed using incremental Bayesian segmentation in order to detect anomalous activity. Theoretical analysis of various aspects of the algorithm and empirical analysis of performance on synthetic data sets are used to tune the algorithm for use as an Intrusion Detection System. Thesis Supervisor: Peter Szolovits Title: Professor
BOVIDS: A deep learning‐based software package for pose estimation to evaluate nightly behavior and its application to common elands (Tragelaphus oryx) in zoos

Abstract Only a few studies on the nocturnal behavior of African ungulates exist so far, with mostly small sample sizes. For a comprehensive understanding of nocturnal behavior, the data basis needs to be expanded. Results obtained by observing zoo animals can provide clues for the study of wild animals and furthermore contribute to a better understanding of animal welfare and better husbandry conditions in zoos. The current contribution reduces the lack of data in two ways. First, we present a stand‐alone open‐source software package based on deep learning techniques, named Behavioral Observations by Videos and Images using Deep‐Learning Software (BOVIDS). It can be used to identify ungulates in their enclosure and to determine the three behavioral poses “Standing,” “Lying—head up,” and “Lying—head down” on 11,411 h of video material with an accuracy of 99.4%. Second, BOVIDS is used to conduct a case study on 25 common elands (Tragelaphus oryx) out of 5 EAZA zoos with a total of 822 nights, yielding the first detailed description of the nightly behavior of common elands. Our results indicate that age and sex are influencing factors on the nocturnal activity budget, the length of behavioral phases as well as the number of phases per behavioral state during the night while the keeping zoo has no significant influence. It is found that males spend more time in REM sleep posture than females while young animals spend more time in this position than adult ones. Finally, the results suggest a rhythm between the Standing and Lying phases among common elands that opens future research directions.
Return to Education Estimation on Self-Employment Entrepreneurs and Their Comparison with Workers in Indonesia

Entrepreneurship in various pieces of literature is mentioned as one aspect that adds value to a country's economy. Using Sakernas August 2019 data and the Mincer income model, this study estimates the educational investment in self-employed entrepreneurs. The results show a positive effect between years of schooling and income earned. Compared to workers, the level of assessment of entrepreneur education looks lower. In addition, this study also looks at how income among entrepreneurs. The Gini coefficient shows 0.47 for self-employed entrepreneurs and 0.41 for workers. There is a sizeable amount of income inequality for self-employed entrepreneurs.
Unraveling the Role of Sex Hormones on Keratinocyte Functions in Human Inflammatory Skin Diseases

The skin exerts several fundamental functions that are the first physical, chemical and immune barriers to the human body. Keratinocytes, the main cell type of the epidermis, provide mechanical defense, support skin integrity and actively endorse cutaneous immune responses. Not surprisingly, considering these crucial activities, alterations in keratinocyte functions are associated with different inflammatory skin diseases. Recent findings indicate that the skin should not only be regarded as a target for hormones but that it should also be considered as an endocrine peripheral organ that is directly involved in the synthesis and metabolism of these chemical messengers. Sex hormones have multiple effects on the skin, attributed to the binding with intracellular receptors expressed by different skin cell populations, including keratinocytes, that activate downstream signaling routes that modulate specific cellular functions and activities. This review is aimed at reorganizing the current knowledge on the role exerted by sex hormones on keratinocyte function in five different inflammatory skin diseases: Hidradenitis suppurativa; Acne vulgaris; Atopic dermatitis; progesterone hypersensitivity; psoriasis. The results of our work aim to provide a deeper insight into common cellular mechanisms and molecular effectors that might constitute putative targets to address for the development of specific therapeutic interventions.