Miracle-dz/UniFAR-FTUs huggingface dataset:
Impact of COVID-19 pandemic on vaccination coverage among children aged 15 to 23 months at Dessie town, Northeast Ethiopia, 2020

ABSTRACT Background: Disturbances are occurring in healthcare, trade, and travel, with countries closing off their borders due to the pandemic of coronavirus disease 2019(COVID-19) in the world. The pandemic has its impact on the delivery of important health services, including vaccinations. This study aimed to assess the impact of COVID-19 on vaccination coverage among children aged 15–23 months. Methods: A community-based cross-sectional study was conducted from July 22 to August 7, 2020, in Dessie town, Ethiopia. 633 children with their mother/caregiver were interviewed. Interviewer administered pre-tested structured questioner was used. Data was entered into EPI data and analyzed by using SPSS (Statistical Package for Social Sciences). Both binary and multivariate logistic regression analyses were tested. In multivariate analysis, a significant association was declared at a p-value of < 0.05. Result: Response rate was 96.4%. Based on the vaccination card plus recall, 350 (57.4%) of children finished all recommended vaccines. Age-eligible vaccination coverage during the COVID-19 outbreak was 12.5% lower than before the outbreak. Being a father main caregiver, mother/caregiver who can write and read, and mother/caregiver who educated from grade 1 to 8 mother/caregiver who is divorced, mother/caregiver who spend more than 30 minutes to reach health institution, and mother/caregiver who aware about the benefit of vaccination, about the campaign, and knowledge of COVID-19 each shows statistically significant association with full vaccination status of children. Conclusion: Full vaccination coverage among children aged 15–23 months remains low in Dessie town, which further decreases after the COVID-19 pandemic. Hence, measures should be taken to increase consciousness about vaccination and the COVID-19 pandemic.
Preclinical pharmacokinetic and pharmacodynamic evaluation of thiazolidinone PG15: an anti‐inflammatory candidate

Objectives Novel 5‐benzilidene thiazolidinones have been synthesized and exhibited anti‐inflammatory activity. In this work one of the compounds of the thiazolidinone chemical series, (5Z,E)‐3‐[2‐(4‐chlorophenyl)‐2‐oxoethyl]‐5‐(1H‐indol‐3‐ ylmethylene)‐thiazolidine‐2,4‐dione (PG15) was investigated aiming to determine the drug's anti‐inflammatory potential in pre‐clinical studies.
Stress and aging: A neurovisceral integration perspective.

Darwin emphasized the intimate relationship between the brain and the heart over 150 years ago. Healthy aging is associated with significant changes in both the brain and the heart. The changes between these, the two most important organs of the body, are linked via the vagus nerve. In this review, we examine the normative changes with aging and the effect that stress may have on how the brain-heart connection changes with age. We provide a framework based on the concept of neurovisceral integration and propose that stress regulation is emotion regulation. As such, studies that have investigated emotion regulation may yield insights into successful stress regulation that helps protect people from age-related decline. In addition, interventions that improve brain health also improve heart health and vice versa. We conclude by noting that significant sex and ethnic differences exist but that future studies are needed to more fully explicate how they may moderate the associations between stress and aging.
Effects of yarn size and blood drop size on wicking and bloodstains in textiles

Bloodstain pattern analysis (BPA) for stains found on non‐porous surfaces has matured into a powerful forensic science tool based on fluid mechanics principles. The same cannot be said when bloodstains are found on porous substrates, such as textiles. This is partially due to the complex nature of textiles with tens of thousands of different materials in addition to unknown wear characteristics. In this study, three single jersey knit fabrics were manufactured from 100% cotton ring‐spun yarns of linear densities of 12, 20, and 30 Ne (492, 295, and 197 dtex, respectively) and nearly identical twist multipliers. Single drops of porcine blood of 2, 10, 30, and 60 µL were allowed to fall 1 cm (to eliminate the impact of blood velocity) onto each fabric to understand the effects of yarn size on wicking and bloodstains. The size of the stain was then measured and compared for different fabrics and blood drop sizes. Wicking of blood into the fabric was fastest for the largest yarn fabrics, but more extensive wicking occurred on finer yarn fabrics resulting in much larger stains. All stains were highly altered due to wicking of blood. The findings from this paper might help the forensic scientists in understanding wicking in textiles and comparing stains on different textiles to gain a better understanding of bloodstains on textiles.
Antiobesity Activity of Aqueous And Ethanol Extracts of Aegle Marmelos Leaves in High Fat Diet Induced Obese Rats

Obesity is a chronic disorder of global prevalence and associated with morbidity and mortality. The presents work evaluates the effect of ethanol (AmEe) and aqueous (AmAe) extracts of Aegle marmelos leaves in high fat diet (HFD) induced obese rats. Male Wistar rats weighing 150-200 g were divided into different groups i.e. Normal control, HFD control, Orlistat (lipase inhibitor), AmEe and AmAe at doses of 200, 400, 250 and 500 mg/kg. Treatment was started after 6 weeks upto 12 weeks along with HFD (except normal control). Oxidative stress was measured by measuring MDA, SOD and GSH level. AmEe and AmAe at 200, 400, 250 and 500 mg/kg/orally significantly attenuated oxidative stress as well as morphological parameters i.e. % body weight gain, BMI, WHR, obesity index, adiposity index respectively as compare to HFD control group . Similarly, serum glucose, triglyceride and total cholesterol were found to be attenuated as compare to HFD control group. Thus AmEe and AmAe exhibited antiobesity activity may due to decrease fat pad mass, by reduced adipocyte differentiation or by decreasing adipocyte hypertrophy in high fat diet induced obese rats.
Empathic responses to social targets: The influence of warmth and competence perceptions, situational valence, and social identification

Accounts of empathy distinguish between cognitive (attribution of mental states to a social target) and emotional (sharing of emotions with a social target) empathy. To date, however, little is known about whether and how (interactions between) person perceptions, situational characteristics, and the observer-target relationship affect these constructs. The current study hence investigated (a) how the perceived warmth and competence of different social targets relate to both types of empathy, (b) whether there are differences in empathic responding to positive vs. negative scenarios, and (c) the impact of identification with the social targets. Eighty-nine participants rated cognitive and emotional empathy regarding four stereotypical target characters (student, elderly person, businessperson, alcoholic person) facing diverse positive and negative events. They also rated how warm and competent these characters appeared to them and how strongly they identified with the social targets. Results for cognitive and emotional empathy were partly overlapping, but demonstrated several significant differences, thereby demonstrating the need to investigate the two concepts separately. Notably, stereotypes of warmth predicted both cognitive and emotional empathic responses more strongly in desirable than in undesirable scenarios, which may relate to greater freedom of response to positive (rather than negative) social outcomes permitted by society. Our data show that scenario valence mattered even more for cognitive (than for emotional) empathy because it additionally moderated the effects of perceived competence and social identification. Finally, both cognitive and emotional empathy increased as a positive function of social identification, and social identification moderated effects exerted by perceived warmth and competence (yet differently for the two types of empathy investigated). Together, these findings speak to empathic responses arising from a complex interplay between perceptions (i.e., warmth and competence), scenario valence, and social identification.
Measuring dysfunctional grief due to a COVID-19 loss: A Turkish validation study of the Pandemic Grief Scale

Abstract The global death toll to date of the COVID-19 pandemic has been enormous, and millions of people are grieving these losses. The aim of the current study is to validate a Turkish version of the Pandemic Grief Scale (PGS), which is a brief English-language mental health screener to identify probable cases of dysfunctional grief associated with a COVID-19 death. Participants were assessed using the PGS, Patient Health Questionnaire-4 (PHQ-4) and Work and Social Adjustment Scale (WSAS). We surveyed 758 Turkish native speakers who participated online. Confirmatory factor analysis showed that the factor structure of the PGS was satisfactory. The scale was internally consistent with a Cronbach's alpha of 0.77 and a composite reliability of 0.90. The PGS demonstrated construct validity with strong correlations with suicidal ideation and substance use coping. Positive correlations of the PGS with the PHQ-4 and the WSAS demonstrated adequate convergent validity. The PGS discriminates well between persons with and without dysfunctional grief using an optimized cut score of ≥ 3 (89% sensitivity and 72% specificity). The PGS also demonstrates incremental validity by explaining most of the variance (43%) in functional impairment due to a COVID-19 loss beyond measures of depression and generalized anxiety. These findings closely replicate the original validation study on the PGS in English and suggest that the current Turkish version of the PGS is a valid and reliable measure to assess the severity of dysfunctional grief associated with a COVID-19 death.
A majority of uninfected adults show preexisting antibody reactivity against SARS-CoV-2

Preexisting cross-reactivity to SARS-CoV-2 occurs in the absence of prior viral exposure. However, this has been difficult to quantify at the population level due to a lack of reliably defined seroreactivity thresholds. Using an orthogonal antibody testing approach, we estimated that about 0.6% of nontriaged adults from the greater Vancouver, Canada, area between May 17 and June 19, 2020, showed clear evidence of a prior SARS-CoV-2 infection, after adjusting for false-positive and false-negative test results. Using a highly sensitive multiplex assay and positive/negative thresholds established in infants in whom maternal antibodies have waned, we determined that more than 90% of uninfected adults showed antibody reactivity against the spike protein, receptor-binding domain (RBD), N-terminal domain (NTD), or the nucleocapsid (N) protein from SARS-CoV-2. This seroreactivity was evenly distributed across age and sex, correlated with circulating coronaviruses’ reactivity, and was partially outcompeted by soluble circulating coronaviruses’ spike. Using a custom SARS-CoV-2 peptide mapping array, we found that this antibody reactivity broadly mapped to spike and to conserved nonstructural viral proteins. We conclude that most adults display preexisting antibody cross-reactivity against SARS-CoV-2, which further supports investigation of how this may impact the clinical severity of COVID-19 or SARS-CoV-2 vaccine responses.
Rationale, Design, and Methodology of a Prospective Cohort Study for Coping with Behavioral and Psychological Symptoms of Dementia: The RECage Project

Background: Behavioral and psychological symptoms of dementia (BPSD) are quite challenging problems during the dementia course. Special Care Units for people with dementia (PwD) and BPSD (SCU-B) are residential medical structures, where BPSD patients are temporarily admitted, in case of unmanageable behavioral disturbances at home. Objective: RECage (REspectful Caring for AGitated Elderly) aspires to assess the short and long-term effectiveness of SCU-Bs toward alleviating BPSD and improving the quality of life (QoL) of PwD and their caregivers. Methods: RECage is a three-year, prospective study enrolling 500 PwD. Particularly, 250 community-dwelling PwDs presenting with severe BPSD will be recruited by five clinical centers across Europe, endowed with a SCU-B, for a short period of time; a second similar group of 250 PwD will be followed by six other no-SCU-B centers solely via outpatient visits. RECage’s endpoints include short and long-term SCU-B clinical efficacy, QoL of patients and caregivers, cost-effectiveness of the SCU-B, psychotropic drug consumption, caregivers’ attitude toward dementia, and time to nursing home placement. Results: PwD admitted in SCU-Bs are expected to have diminished rates of BPSD and better QoL and their caregivers are also expected to have better QoL and improved attitude towards dementia, compared to those followed in no-SCU-Bs. Also, the cost of care and the psychotropic drug consumption are expected to be lower. Finally, PwD followed in no-SCU-Bs are expected to have earlier admission to nursing homes. Conclusion: The cohort study results will refine the SCU-B model, issuing recommendations for implementation of SCU-Bs in the countries where they are scarce or non-existent.
RNA‐Seq analysis of knocking out the neuroprotective proton‐sensitive GPR68 on basal and acute ischemia‐induced transcriptome changes and signaling in mouse brain

Brain acid signaling plays important roles in both physiological and disease conditions. One key neuronal metabotropic proton receptor in the brain is GPR68, which contributes to hippocampal long‐term potentiation (LTP) and mediates neuroprotection in acidotic and ischemic conditions. Here, to gain greater understanding of GPR68 function in the brain, we performed mRNA‐Seq analysis in mice. First, we studied sham‐operated animals to determine baseline expression. Compared to wild type (WT), GPR68−/− (KO) brain downregulated genes that are enriched in Gene Ontology (GO) terms of misfolding protein binding, response to organic cyclic compounds, and endoplasmic reticulum chaperone complex. Next, we examined the expression profile following transient middle cerebral artery occlusion (tMCAO). tMCAO‐upregulated genes cluster to cytokine/chemokine‐related functions and immune responses, while tMCAO‐downregulated genes cluster to channel activities and synaptic signaling. For proton‐sensitive receptors, tMCAO downregulated ASIC1a and upregulated GPR4 and GPR65, but had no effect on ASIC2, PAC, or GPR68. GPR68 deletion did not alter the expression of these proton receptors, either at baseline or after ischemia. Lastly, we performed GeneVenn analysis of differential genes at baseline and post‐tMCAO. Ischemia upregulated the expression of three hemoglobin genes, along with H2‐Aa, Ppbp, Siglece, and Tagln, in WT but not in KO. Immunostaining showed that tMCAO‐induced hemoglobin localized to neurons. Western blot analysis further showed that hemoglobin induction is GPR68‐dependent. Together, these data suggest that GPR68 deletion at baseline disrupts chaperone functions and cellular signaling responses and imply a contribution of hemoglobin‐mediated antioxidant mechanism to GPR68‐dependent neuroprotection in ischemia.
Cooperative feeding in common dolphins as suggested by ontogenetic patterns in δ15 N bulk and amino acids.

Understanding the effect of stage-specific traits on species feeding habits can reveal how natural selection shapes life strategies. Amino acid (AA) nitrogen stable isotopes (δ15 N) provide multiple proxies of habitat baseline values and diet that can improve our understanding of species feeding strategies relative to their animal metabolism. We evaluated the effect of body length as a proxy for life-stage and sex on the feeding habits of the common dolphin (Delphinus delphis delphis) using δ13 C and δ15 N in bulk tissue and AAs δ15 N from skin samples collected for almost two decades. For bulk δ13 C and δ15 N data, we used SIBER analysis to compare isotopic niches by sex and life-stage. For AA δ15 N data, we developed a hierarchical Bayesian model (HBM) to estimate indices of trophic status (Δ15 N and trophic position). The model reflected the natural hierarchical structure of AA data by partitioning variability into 3 sources: between laboratory replicates, within dolphins, and among dolphins. Estimates of Δ15 N based on all trophic and source AAs were more precise for each dolphin, less variable among dolphins, and on average 2.4‰ higher than indices based on single trophic (Glx) and source (Phe) AAs. Precision was further increased when information was shared among individuals through random effects or regression models. Estimates of trophic position showed similar patterns. Both Δ15 N and δ15 Nbulk isotopic niches showed no difference by sex, suggesting that males and females have similar feeding habits and may not segregate. However, lower Δ15N values for weaning calves and smaller juveniles discriminate them from adults, whereas δ15 N bulk isotopic niches do not. A trophic discrimination factor (TDFTro-Src ) of 3.1‰ was required for reasonable estimates of trophic position for these dolphins. Together, the lack of δ15 N differences between sexes, low variation between juveniles and adults, and knowledge of common dolphins' social organization support intraspecific feeding cooperation as an important strategy to feed in the highly dynamic marine environment. Our study also presents an efficient way to analyze complex AA δ15 N data using HBM to investigate foraging behavior in long-lived marine species difficult to study in the wild.
Accuracy of abbreviated protocols for unattended automated office blood pressure measurements, a retrospective study

Background Blood pressure measurement (BPM) is one of the most often performed procedures in clinical practice, but especially office BPM is prone to errors. Unattended automated office BPM (AOBPM) is somewhat standardised and observer-independent, but time and space consuming. We aimed to assess whether an AOBPM protocol can be abbreviated without losing accuracy. Design In our retrospective single centre study, we used all AOBPM (AOBPM protocol of the SPRINT study), collected over 14 months. Three sequential BPM (after 5 minutes of rest, spaced 2 minutes) were automatically recorded with the patient alone in a quiet room resulting in three systolic and diastolic values. We compared the mean of all three (RefProt) with the mean of the first two (ShortProtA) and the single first BPM (ShortProtB). Results We analysed 413 AOBPM sets from 210 patients. Mean age was 52±16 years. Mean values for RefProt were 128.3/81.3 mmHg, for ShortProtA 128.4/81.4 mmHg, for ShortProtB 128.8/81.4 mmHg. Mean difference and limits of agreement for RefProt vs. ShortProtA and ShortProtB were -0.1±4.2/-0.1±2.8 mmHg and -0.5±8.1/-0.1±5.3 mmHg, respectively. With ShortProtA, 83% of systolic and 92% of diastolic measurements were within 2 mmHg from RefProt (67/82% for ShortProtB). ShortProtA or ShortProtB led to no significant hypertensive reclassifications in comparison to RefProt (p-values 0.774/1.000/1.000/0.556). Conclusion Based on our results differences between the RefProt and ShortProtA are minimal and within acceptable limits of agreement. Therefore, the automated procedure may be shorted from 3 to 2 measurements, but a single measurement is insufficient.
Addressing Phantom Pain Through Occupational Participation: A Qualitative Study of Support Group Participants

The purpose of this qualitative phenomenological study was to explore the adaptation process of support group participants who are survivors of lower limb amputation (LLA) experiencing phantom limb pain (PLP). The study followed a qualitative, descriptive phenomenological design. Ten adult participants with LLA met inclusion criteria and through semi-structured interviews shared their lived experience. A qualitative descriptive methodology was used to analyze the data collected from interview transcriptions. Analysis involved coding and theme development. Three themes emerged: PLP interrupted but does not prevent participation, adapting to PLP allowed for continued participation in meaningful occupations, and education to promote self-management of PLP. Themes identified highlight the importance of social support and early education on PLP to facilitate the adaption process and promote occupational participation. The finding underscores the value of empowering survivors to self-manage pain through their own personal and unique ways.
Palliative endoscopic retrograde biliary drainage for malignant biliary obstruction in Korea: A nationwide assessment

Background: Malignant biliary obstruction (MBO) is usually caused by biliary tract cancer or pancreatic cancer. This study was performed to summarize the current situation regarding palliative endoscopic retrograde biliary drainage (ERBD) for MBO in Korea and to determine its clinical significance by analyzing representative nationwide data. Methods: Patients that underwent palliative ERBD for MBO between 2012 and 2015 were identified using the Health Insurance Review and Assessment database, which covers the entire Korean population. We assessed clinical characteristics and complications and compared the clinical impacts of initial metal and plastic stenting in these patients. Results: A total of 9,728 subjects (mean age, 65 ± 11.4 years; male, 61.4%) were identified and analyzed. The most common diagnosis was malignant neoplasm of liver and intrahepatic bile ducts (32.1%) and this was followed by extrahepatic or Ampulla of Vater cancer and pancreatic cancer. Initial plastic stent(s) placement was performed in 52.9% of the study subjects, and metal stent(s) placement was performed in 23.3%. The number of sessions of endoscopic retrograde cholangiopancreatography (ERCP) or percutaneous transhepatic biliary drainage (PTBD) was significantly higher in patients that underwent initial plastic stenting than in patients that underwent metal stenting (2.2 ± 1.7 vs 1.8 ± 1.4, P < 0.0001), but rates of post-ERCP pancreatitis, hospital days, and time to second ERCP or PTBD were not significantly different. Conclusion: This nationwide assessment study suggests that initial metal stenting is associated with fewer sessions of total ERCP or PTBD following the initial procedure, despite the preference for initial plastic stenting in Korea.
Epidemiology of coronaviruses, genetics, vaccines, and scenario of current pandemic of coronavirus diseases 2019 (COVID-19): a fuzzy set approach

ABSTRACT Human coronaviruses (HCoVs) are associated with a range of respiratory complications. In the last two decades, three major outbreaks have been reported due to HCoVs including the current pandemic. In December 2019, a newly emerged virus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first reported in Wuhan city, China. This paper presents a detailed review of the literature and discusses the uncertain spread of coronavirus disease 2019 (COVID-19) using fuzzy set as classical set theory logic to measure uncertainty and vagueness of COVID-19 in China. Our findings show that both infection and death rate touched the peak (normal fuzzy sets) and have shown a decline. The graphs are not convex, which shows that there remains much uncertainty in the spread of COVID-19. Effective vaccines are clearly needed to control and prevent the COVID-19 pandemic.