Miracle-dz/UniFAR-FTUs huggingface dataset:
The Ins and Outs of RAS Effector Complexes

RAS oncogenes are among the most commonly mutated proteins in human cancers. They regulate a wide range of effector pathways that control cell proliferation, survival, differentiation, migration and metabolic status. Including aberrations in these pathways, RAS-dependent signaling is altered in more than half of human cancers. Targeting mutant RAS proteins and their downstream oncogenic signaling pathways has been elusive. However, recent results comprising detailed molecular studies, large scale omics studies and computational modeling have painted a new and more comprehensive portrait of RAS signaling that helps us to understand the intricacies of RAS, how its physiological and pathophysiological functions are regulated, and how we can target them. Here, we review these efforts particularly trying to relate the detailed mechanistic studies with global functional studies. We highlight the importance of computational modeling and data integration to derive an actionable understanding of RAS signaling that will allow us to design new mechanism-based therapies for RAS mutated cancers.
An Experimental Analysis of Deep Learning Architectures for Supervised Speech Enhancement

Recent speech enhancement research has shown that deep learning techniques are very effective in removing background noise. Many deep neural networks are being proposed, showing promising results for improving overall speech perception. The Deep Multilayer Perceptron, Convolutional Neural Networks, and the Denoising Autoencoder are well-established architectures for speech enhancement; however, choosing between different deep learning models has been mainly empirical. Consequently, a comparative analysis is needed between these three architecture types in order to show the factors affecting their performance. In this paper, this analysis is presented by comparing seven deep learning models that belong to these three categories. The comparison includes evaluating the performance in terms of the overall quality of the output speech using five objective evaluation metrics and a subjective evaluation with 23 listeners; the ability to deal with challenging noise conditions; generalization ability; complexity; and, processing time. Further analysis is then provided while using two different approaches. The first approach investigates how the performance is affected by changing network hyperparameters and the structure of the data, including the Lombard effect. While the second approach interprets the results by visualizing the spectrogram of the output layer of all the investigated models, and the spectrograms of the hidden layers of the convolutional neural network architecture. Finally, a general evaluation is performed for supervised deep learning-based speech enhancement while using SWOC analysis, to discuss the technique’s Strengths, Weaknesses, Opportunities, and Challenges. The results of this paper contribute to the understanding of how different deep neural networks perform the speech enhancement task, highlight the strengths and weaknesses of each architecture, and provide recommendations for achieving better performance. This work facilitates the development of better deep neural networks for speech enhancement in the future.
Could the new COVID-19 mutant strain undermine vaccination efforts? A mathematical modelling approach for estimating the spread of the UK mutant strain using Ontario, Canada, as a case study

Background: Infections represent highly dynamic processes, characterized by evolutionary changes and events that involve both the pathogen and the host. Among infectious agents, viruses, such as the "Severe Acute Respiratory Syndrome-related Coronavirus type 2" (SARS-CoV-2), the infectious agent responsible for the currently ongoing "Coronavirus disease 2019" (COVID-2019) pandemic, have a particularly high mutation rate. Taking into account the mutational landscape of an infectious agent, it is important to shed light on its evolution capability over time. As new, more infectious strains of COVID-19 emerge around the world, it is imperative to estimate when these new strains may overtake the wild-type strain in different populations. Therefore, we developed a general-purpose framework to estimate the time at which a mutant variant is able to takeover a wild-type strain during an emerging infectious diseases outbreak. In this study, we used COVID-19 as a case-study, but the model is adaptable to any emerging pathogens. Methods and findings: We devise a two-strain mathematical framework, to model a wild- and a mutant-type viral population and fit cumulative case data to parameterize the model, using Ontario as a case study. We found that, in the context of under-reporting and the current case levels, a variant strain is unlikely to dominate until March/April 2021. Current non-pharmaceutical interventions in Ontario need to be kept in place longer even with vaccination in order to prevent another outbreak. The spread of a variant strain in Ontario will mostly likely be observed by a widened peak of the daily reported cases. If vaccine efficacy is maintained across strains, then it is still possible to have an immune population by end of 2021. Conclusions: Our findings have important practical implications in terms of public health as policy-and decision-makers are equipped with a mathematical tool that can enable the estimation of the take-over of a mutant strain of an emerging infectious disease.
The Effect of Parenting Patterns on Pre School Age Children Development in South Central Timor

Quick Response Code Abstract: Parenting patterns are the care that is given by the mother or other caregivers in the form of attitudes and behaviors in terms of their closeness to children, feeding, caring for cleanliness, giving love and so on. Good care is very important to ensure optimal growth and development of children, therefore, poor care can cause children to have less nutritional status. This type of research is analytic observational usingdesign cross sectional. The sample in this study was parents and pre-school children aged 4-5 years, so that the number of samples in each region was 73 parents and 73 preschool children aged 4-5 years. Sampling was done by using cluster sampling method, purposive sampling and stratified sampling. The results of thetest chi square showed that the p-value was smaller than α 0.05, so the analysis showed that there was a significant effect of feeding practices on children's development. The results of thetest chi square showed that the p-value was 0.000 smaller than α 0.05, so the analysis showed that there was a significant effect of hygiene and health practices on children's development. The results of thetest chi square showed a p-value of 0.000 smaller α 0.05, so the results of the analysis showed that there was a significant effect of the practice of hygienic affection on child development. The results of thetest chi square showed a p-value of 0.000 smaller α 0.05, so the results of the analysis showed a significant effect of stimulation practice on child development.
The Discrete Vickrey Auction and the Role of Ties

A typical assumption in the auction literature is that bidders can submit any bid within the non-negative part of the real line. Yet, when auctions are used the set of bids is restricted at least to a countably infinite set due to the discrete nature of currency, and often even to a finite set. We study the effects of explicitly modeling a restricted set of allowed bids in a Vickrey auction within the independent values framework. We present a characterization of all pure strategy equilibria of the unrestricted Vickrey auction, obtained by Blume and Heidhues (2004), and analyze how this set changes when we restrict ourselves to the Vickrey auction with a restricted set of bids, although we do not provide a complete description of this set. We discuss the consequences of the change of the equilibria on the seller’s revenue and the consequences of a set of equilibria that is present in both models. We examine a tool that is available for the auctioneer to obtain a positive expected revenue, namely a proper specification ex-ante of a dictatorial tie-breaking rule. We also explore the consequences of introducing of a reservation price in our setup, knowing that it yields a unique equilibrium in the non-restricted allowed bids case, as shown by Blume and Heidhues (2001). Finally, we summarize our contributions and provide a list of the several questions that remain open in the field.
Psychological Well-being among Community-Dwelling Older Adults Living with Chronic Illness

ชนัญชดิาดษุฎ ีทลูศริ1ิ* และ นารรัีตน ์บญุเนตร2 Chanandchidadussadee Toonsiri1* and Nareerat Boonnate2 1 สาขาวชิาการพยาบาลชมุชน 2 สาขาวชิาการพยาบาลมารดา ทารก และการผดงุครรภ ์ 1-2 คณะพยาบาลศาสตร ์มหาวทิยาลยับรูพา อ. เมอืงชลบรุ ีจ. ชลบรุ ี20131 1 Community Nursing Department 2 Maternal-Newborn Nursing and Midwifery Department 1-2 Faculty of Nursing, Burapha University, Muang Chonburi, Chonburi, 20131, Thailand * Corresponding author: stoonsiri@hotmail.com * Corresponding author: stoonsiri@hotmail.com วารสารไทยเภสชัศาสตรแ์ละวทิยาการสขุภาพ2563;15(2):116-123. Thai Pharmaceutical and Health Science Journal 2020;15(2):116-123.
Screening of Sixteen Commonly Consumed Green Leafy Vegetables for Carotenoids

Background and Objective: The epidemiology of central line-associated bloodstream infections in Al Noor Hospital Specialist Hospital has not previously been reported. We sought to describe time-trends in central line-associated bloodstream infections rates, etiology, and responsible pathogens for the period January 1, 2016-December 31, 2018. Materials and Methods: All 120 patients age 18 years and older admitted to all departments of a Tertiary Hospital who had double lumen catheters inserted during the study period were followed up and monitored for central line-associated bloodstream infections. Results: From 120 patients who had a central venous catheter inserted, 20 developed blood infections. The catheterization duration was significantly longer with approximately 11 days among the infected against 6 days in non-infected. The most frequently isolated organism was Klebsiella pneumonieae. The infection rate recorded were 30.67, 23.06, and 16.39 per 1000 catheter days in 2016, 2017, and 2018 respectively. The overall rate for the 2 years of study was 24.06 per 1000 catheter days. Conclusion: Keeping the catheter beyond the period required increases infection rate while avoiding femoral catheter site insertion leads to reduction. If the Line Care Protocol of best practices and education of staff regarding the protocol are implemented infection rates will reduce.
Formation and determination of the individual area of oilseed radish leaves in agrophytocenosises of different technological construction

For the successful control of the production process, determining the leaf area is a basic requirement. In this context, it is important to determine the regularities of leaf formation within the plant, considering technological parameters of agrophytocenosis construction. These are the important issues covered in this paper based on the years of research conducted between 2013 and 2018 on three cultivars of oilseed radish: one of the poorly explored members of the cruciferous family of multipurpose use. The conducted researches allowed to distinguish features of longline leaf formation of oilseed radish cultivars and mathematically describe features of formation of their area, length and width at the early flowering phase according to the Richards growth curve. The peculiarities of formation of individual leaf area depending on the combination of the variations of the stand density and fertilization in the context of the recommended process regulation of oilseed radish cultivation are also determined. It has been proved possible to use a non destructive method of determining the individual leaf area of oilseed radish, basing on the evaluation of 29 models, using the following formula S = 7.9316 2.3613L + 0.6897 (LW)+0.0458L2 0.0005 (LW)2 (under the following test parameters of the model: R2 0.9106; RMSE 9.75; d 0.956; BIAS 0.1523).
Investigation of Chloride Diffusion for High-Performance Concrete Containing Fly Ash, Microsilica, and Chemical Admixtures

This study evaluated the influence of addition of fly ash, microsilica (MS), and calcium nitrite solution (CN) on chloride diffusion of high-performance concrete. The concentrations of chloride ions penetrating specimens through diffusion were measured periodically, up to one year, by using an electronic ion/pH meter. When the diffusion flux reached a steady state, the diffusion coefficients of all mixes were calculated based on Fick's first law. The test results demonstrated that the 25% addition of fly ash by weight of cement improved the mix's resistance to chloride diffusion. The improvement was especially evident when 25% of fly ash and 10% of MS by weight of cement were added into the mix together. However, the addition of CN into the mix resulted in deterioration in improvement of resistance to chloride diffusion enhanced by the incorporation of fly ash and MS. Through the mercury intrusion porosimetry test, the influence of CN on chloride diffusion is studied further. The results showed that the addition of CN leads to the increase of micropore diameter. Therefore, CN should be adopted cautiously in the practical engineering in which higher resistance to chloride diffusion is required.
Exceptional activity of mesoporous β-MnO2 in the catalytic thermal sensitization of ammonium perchlorate

Mesoporous β-MnO2 has been prepared, characterized and demonstrated to possess excellent catalytic activity in the thermal decomposition of ammonium perchlorate. The observed unprecedentedly low decomposition temperatures, fast reaction rates and enhanced heat releases in the catalysed formulations make mesoporous β-MnO2 promising as a high-performing ballistic modifier in AP-based composite solid rocket propellants.
Déjà Vécu: When Groundhog Day Gets Real

Deja vecu is an extremely rare type of identifying paramnesia characterised by the ongoing sensation of having experienced things before. Having the delusional conviction that this sensation is true, patients frequently exhibit recollective confabulation. We here describe an 84-year-old woman with idiopathic, partial deja vecu, where her symptoms were limited to people and events. An extensive psychiatric and somatic work-up ruled out cerebrovascular disease, epilepsy, dementia, psychosis, or intoxication as a potential underlying cause. Proposed to be a functional disturbance of the limbic system with the involvement of a network that comprises at least the hippocampus and entorhinal cortex, the pathophysiology of deja vecu is in need of further elucidation. Our patient and her family were offered psychoeducation, which led to acceptance and improved coping. During the two-year follow-up, the deja vecu sensations continued unaltered, but all involved were less bothered by them, with the patient’s functioning improving both personally and socially.
Evaluate the needs of prosthodontic and orthodontic care among individuals with special needs

Pradeep Subbaiah*1, Dhakshaini MR2, Raghunath N1, Nataraja NP3 1Department of Orthodontics and Dentofacial Orthopaedics, JSS Dental College and Hospital, JSS Academy of Higher Education and Research, Mysuru – 570015, Karnataka, India 2Department of Prosthodontics and Crown and Bridge, JSS Dental College and Hospital, JSS Academy of Higher Education and Research, Mysuru – 570015, Karnataka, India 3JSS Institute of Speech and Hearing, MG Road, Mysuru – 570004, Karnataka, India
Factor Proportion Theory: Evidence from Kenya

This paper examined empirically if Kenya‟s pattern of trade with India is consistent with Heckscher-Ohlin theory, using a fixed-effect panel data model and macroeconomic variables for the period 1970 to 2013. The findings indicate a strong trade relation between Kenya and India, with Kenya specializing in the exportation of primary products to India. Overall, the findings indicate that the Kenya–India trade relation is consistent with the factor proportions theory, which spells out the trade relationship between the North – South poles. The paper recommends that Kenyan government should encourage Indian investors to establish subsidiaries of their manufacturing companies in Kenya in order to reduce the cost of importation of capital intensive goods and create jobs in the domestic economy.
Effect of Bank Financial Intermediation on Agricultural Performance in Nigeria

This study examined the effect of bank financial intermediation on the performance of agricultural sector in Nigeria between 1992 and 2017. Time series data were collected from the Central Bank of Nigeria (CBN) Statistical Bulletin. Agricultural sector output (AGOUT) was proxied as the endogenous variable to measure the performance of agricultural sector, and regressed on Commercial Bank Credits to Agricultural sector (CBCA), Commercial banks’ Gross Saving deposits (CGSD), Microfinance Bank Credits to Agricultural sector (MBCA), Microfinance banks’ Gross Saving Deposits (MGSD) and Deposit Interest Rate (DIR) as the proxies of bank financial intermediation. Autoregressive Distributed Lag (ARDL) Model was employed for data analysis. The results showed that the previous year deviation from long-run equilibrium was corrected in the current period at an adjustment speed of 22%. The result also showed that in the long run, most of the bank financial intermediation variables were positively and insignificantly stimulating agricultural performance in Nigeria. Based on these findings, it was concluded that bank financial intermediation was positive but insignificant determinant of agricultural performance in Nigeria in the long run. It was therefore, recommended that government through the Central Bank of Nigeria (CBN) should moderately increase the deposit interest rate to encourage savings while special directive should be given to banks to give priority to lending request from agricultural sector.
Medical students' views of e-learning-based medical education during COVID-19 pandemic

The number of multimedia courseware developed to assist teaching and learning activities has increased tremendously, following the declaration of schools’ closure during COVID-19 pandemic. This study aimed at e- learning experiences of 550 students of a medical school in Iran during the time Coronavirus pandemic hit Iran. To achieve the objectives of this study, a self-devised questionnaire was used, and the data were analyzed using Independent samples T. test, ANOVA, and MANOVA. Results have demonstrated that university students had a satisfactory e-learning experience during the lockdown with an exception for online synchronous classes. This study also showed that older students are more satisfied with e-learning and that there was a significant difference between the overall mean score of those who had access to PCs and laptops compared to those who had accessed only to mobile phones. Our results also showed a significant difference exists between the e-learning experience of students who had experienced virtual classes prior to Covid-19 pandemic and those who had not; however, no significant difference was seen in terms of the residence of the students and their gender.
The Influence of Entrepreneurship Learning And Individual Commitment Toward Achievement Motivation And Its Impact on The Interest of Business Establishment For Vocational High School Students In Makassar, Indonesia

This study aimed at reviewing attitude and behavior of Vocational High School students in Makassar city by analyzing causal relationships between entrepreneurship learning, individual commitment, achievement motivation and the interest of business establishment. In this study, survey method was used as an approach to 4000 vocational high school students in Makassar city as population. The sample was obtained through Malhotra formula by multiplying all indicators or question items with five and the research sample was 200 students. The questionnaire was used as a technique of data collection, and Structural Equation Model (SEM) was used as an analysis. The result of the analysis showed that there was a significant influence on entrepreneurship learning and individual commitment to the interest of business establishment. The relationship was influenced both directly and indirectly through achievement motivation. It was concluded that entrepreneurship competencies influenced the interest of vocational high school students in Makassar to establish the business. The entrepreneurship competencies were entrepreneurship learning, individual commitment, and achievement motivation.
Evaluation of tear quantity and quality treated with gintonin eye drops in Labrador retrievers and English springer spaniels

The aims of this study were to determine the relationship between tear osmolarity (TO), Schirmer tear test-1 (STT1) and tear film break-up time (TBUT) values in canines and to determine the impact of eye drops containing gintonin a ginseng-derived lysophosphatidic acid (LPA) receptor ligand on these indices. Fourteen canines (four English springer spaniels and ten Labrador retrievers) were randomized into two groups: the control group received only placebo eye drops (carboxymethylcellulose), while the experimental group received carboxymethylcellulose eye drops containing 5 μg of gintonin. Treatment was applied twice per day for a period of four weeks and STT-1, TBUT and TO were evaluated both prior to and following the treatment period; the latter using I-PEN® VET (I-MED Animal Health, QC, Canada). Pearson's correlation coefficients were calculated to investigate potential associations between baseline TO, STT-1 and TBUT values. Within-group statistical significance of value changes induced by treatment was determined using Student’s t-test. Positive correlations exist between TO and STT-1 values, as well as between TO and TBUT values (P = 0.001 and P = 0.032, respectively). Gintonin treatment significantly increased only TBUT (21.0 ± 11.2 s versus 7.5 ± 2.8 s) and TO (317.1 ± 18.1 mOsm/L versus 302.2 ± 19.3 mOsm/L) values (P < 0.01 and P < 0.05, respectively). The results suggest that gintonin improves canine tear film quality, as indicated by increased TBUT and TO values.
Diagnostic Role of Osteopontin in Interstitial Lung Disease

Objective: Early diagnosis of interstitial lung disease (ILD) is desirable not only to better define pathobiological mechanisms, but also to customize treatment protocols. As osteopontin (OPN) expression may be linked to the fibrotic remodelling in ILD, this present study was planned to evaluate the usefulness of its estimation in serum for the diagnosis of ILD. Material and Methods: Serum OPN levels were estimated by enzyme-linked immunosorbent assay in 52 diagnosed cases of ILD, that were then compared with 46 patients with chronic obstructive lung disease and 46 apparently healthy controls. Results: Median levels of serum OPN were found to be significantly higher in patients with ILD, 2.186 nanograms per milliliter (ng/ml), as compared to patients with chronic obstructive lung disease and healthy controls (1.687 and 1.923 ng/ml, respectively). The best cutoff levels of OPN, for diagnosis of ILD, was found to be >1.08 ng/ml; with a sensitivity of 88.4% and specificity of 32.6%. Of the various subtypes, serum OPN levels were found to be highest in patients with idiopathic pulmonary fibrosis and interstitial pneumonia with autoimmune features; although the difference in levels between various subgroups was not found to be statistically significant (p-value=0.495). Conclusion: Serum concentration of OPN was found to be increased in patients with ILD and may be used to aid diagnosis. This opens new avenues for future research in patients with ILD, not only for the validation of the diagnostic abilities of OPN, but also as a potential target in its treatment.