Miracle-dz/UniFAR-FTUs huggingface dataset:
Immunotherapy and Immune Infiltration in Patients with Clear Cell Renal Cell Carcinoma: A Comprehensive Analysis

On a global scale, renal cell carcinoma (RCC) is the second most common form of cancer and the 10th leading cause of cancer-related deaths. There are about 70% of cases of RCC that are clear cell renal cell carcinomas (ccRCCs). This study explores possible targets for immune therapy in patients with RCC. In the recent years, immunotherapy has been applied to RCC patients. In order to identify genes that are closely associated with immune cells, a weighted gene coexpression network analysis (WGCNA) was conducted. A close association was found between genes involved in MEred and M0 macrophages, M1 macrophages, and M2 macrophages. A prognostic prediction model is subsequently developed by incorporating the OS and the expression level of key genes from the RCC cohort into a univariate COX regression analysis, a multivariate COX regression analysis, and a combined COX regression analysis. We finally discovered that 6 genes are closely associated with the prognosis of RCC patients, including SLC16A12, SLC2A9, IGF2BP2, EMX2, ANK3, and METTL7A. The survival analysis proved the prognostic prediction value of the model. The 1-year, 3-year, and 5-year AUC of ROC curves are 0.759, 0.723, and 0.733, respectively. For clinical ROC curves, the AUC score for risk score, stage, grade, and T stage is 0.759, 0.824, 0722, and 0.736, respectively. The nomogram was constructed for better prognosis prediction of RCC patients. In addition, GSVA and GO enrichment analysis was performed to explore the potential pathways that are closely associated with genes involved in the prognostic prediction model. Accordingly, our study demonstrates that immune cells play a crucial role in RCC infiltration. The development of a prognostic prediction model is a potential new prognostic biomarker and potential immunotherapy target for tumors.
The Relationship between Total Precipitable Water and Surface Dew Point

Abstract Mean monthly and annual values of total precipitable water are compared with mean monthly and annual values of surface dew point for each 5° latitude circle from the equator to 85°S. The correlation coefficients are lower for latitudes 0–20°S than for latitudes 25–85°S. The degree of relationship between mean monthly values of total precipitable water and mean monthly values of surface dew point is good in winter for all latitudes but much weaker in warmer months for latitudes 0–20°S. The computed regression equations give excellent estimates of monthly mean zonally averaged precipitable water from surface dew point for middle and higher latitudes in cooler seasons. Zonally averaged values of the moisture profile power index λ for the Southern Hemisphere are presented. This power index is highly variable (−0.26 to +4.57) even for mean monthly moisture profiles. These results are useful for the zonally averaged climatic models.
Chemical composition and energy potential of woody species in dry forest: subsidies for sustainable forest management

: Energy demand, especially in developing countries, is partly supplied by firewood and charcoal from natural forests. However, there are not always previous studies of energy quality, with implications for forest management. This study aimed to characterize the energy potential of the wood of six shrub-tree species from the Caatinga and the influence of the circumference class on their chemical properties and energy potential to subsidize forest management. Thus, Anadenanthera colubrina var. cebil (Angico), Cenostigma bracteosum (Catingueira), Cnidoscolus quercifolius (Faveleira), Mimosa ophthalmocentra (Jurema branca), Mimosa tenuiflora (Jurema preta) and Aspidosperma pyrifolium (Pereiro) from an area of Dry Forest (Caatinga) in Floresta, Pernambuco state, Brazil, were analyzed. Each species had three individuals sampled in five circumference classes (I a V) at 1.30 m from the ground. Carbon, hydrogen, nitrogen, insoluble lignin, and ash contents, as well as higher and lower calorific values, apparent and energetic densities and energy production were evaluated. Then, a completely randomized design in a factorial arrangement (species x circumference classes) with three replications, and comparison of means (Tukey’s test, p < 0.05) were considered in the statistical analysis. A Cluster analysis was also performed aiming at joint analysis of variables. The results showed that the biomass of M. ophthalmocentra and M. tenuiflora have the highest energy density and amount of energy per unit of mass. C. quercifolius and A. pyrifolium were lower when compared to the other species. In addition, M. ophthalmocentra , M. tenuiflora , A. colubrina and C. bracteosum stood out for energy generation. Classes IV and V can be indicated as biomass for combustion, while class I has disadvantages due to higher nitrogen content and lower upper and lower calorific values .
Prevalence, Genetic Homogeneity, and Antibiotic Resistance of Pathogenic Yersinia enterocolitica Strains Isolated from Slaughtered Pigs in Bulgaria

Yersiniosis is the third most commonly reported foodborne zoonosis in the European Union. Here, we evaluated the prevalence of pathogenic Yersinia enterocolitica among healthy pigs (as a major reservoir) in a slaughterhouse in Bulgaria. A total of 790 tonsils and feces from 601 pigs were examined. Isolation and pathogenicity characterization was carried out by the ISO 10273:2003 protocol and Polymerase Chain Reaction (PCR), detecting the 16S rRNA gene, attachment and invasion locus (ail), Yersinia heat-stable enterotoxin (ystA), and Yersinia adhesion (yadA) genes. Genetic diversity was assessed by pulsed-field gel electrophoresis (PFGE), and antimicrobial resistance by the standard disk diffusion method. Of all the pigs tested, 6.7% were positive for Y. enterocolitica. All isolates belonged to Y. enterocolitica bioserotype 4/O:3. ail, and ystA genes were detected in all positive strains (n = 43), while the plasmid Yersinia virulence plasmid (pYV) was detected in 41. High homogeneity was observed among the strains, with all strains susceptible to ceftriaxone, amikacin and ciprofloxacin, and resistant to ampicillin. In conclusion, a low prevalence of Y. enterocolitica 4/O:3 was found in healthy pigs slaughtered in Bulgaria, not underestimating possible contamination of pork as a potential risk to consumer health.
Applications of Deep Learning and Machine Learning in Computational Medicine

Computational medicine has emerged due to the advances in medical technology in parallel with big data and artificial intelligence. A new way of treating complex diseases is evolving called 'Precision Medicine' fueled by big data extracting meaningful information from individual variability. At the forefront is biomedical research aiming to promote the area of precision medicine. Though traditional machine learning methods have built successful models for cancer diagnosis to sars-cov2 pulmonary infection, the advent of modern deep learning methods has had phenomenal growth in genomics, electronic health records, and drug development. The challenges in Deep learning applications in medicine include lack of data, privacy, heterogeneity of data, and interpretability. Analysis and discussion on these problems provide a reference to improve the application of deep learning in medical health.
Metric and Non-Metric Dental Traits of Premolars with Root Canals Configuration among the Egyptians

Objective: To evaluate and compare metric, non-metric dental traits with root canals configuration in Egyptian premolars. Materials and methods: 200 extracted premolars were assorted in four groups; maxillary 1 st (UP1), maxillary 2 nd (UP2), mandibular 1 st (LP1) and mandibular 2 nd (LP2). Assessment of metric and non-metric dental traits with root canals configuration were performed. Metric data were statistically analyzed using F-one-way analysis of variance and Tukey’s Post Hoc test, while Chi-square test for non-metric data and canals configuration. Results: Root length/Crown height mean was significantly higher in 2 nd than 1 st premolars. Mesio-distal mean of UP1 was the highest, then mandibular premolars, then UP2. Bucco-lingual and inter-cuspal distance means of maxillary were larger than mandibular premolars. Distal accessory ridges occurrence was higher than mesial ridges, and showed higher values in 1 st than 2 nd premolars. Odontome only expressed in LP1. Mesial accessory cusps occurrence was lower than distal ones in UP1, while the UP2 showed only mesial cusps. The most common pattern was one lingual cusp and two lingual cusps in LP1 and LP2 respectively. The frequency of one-rooted maxillary premolars was higher than two-rooted ones. The occurrence of radicular groove was significantly higher in LP1 than LP2. The most common root canal anatomy was type IV in maxillary premolars. UP2 showed types XIII, XVI and XIX. Most of mandibular premolars exhibited type I. LP1 showed types IX and 1-3-2 canals. Conclusion: There were differences in metric/non-metric dental traits and canals configuration between Egyptian premolars with difference in their expression amongst populations.
Fabrication of Hydrogel-Based Composite Fibers and Computer Simulation of the Filler Dynamics in the Composite Flow

Fibrous structures with anisotropic fillers as composites have found increasing interest in the field of biofabrication since they can mimic the extracellular matrix of anisotropic tissues such as skeletal muscle or nerve tissue. In the present work, the inclusion of anisotropic fillers in hydrogel-based filaments with an interpenetrating polymeric network (IPN) was evaluated and the dynamics of such fillers in the composite flow were analyzed using computational simulations. In the experimental part, microfabricated rods (200 and 400 μm length, 50 μm width) were used as anisotropic fillers in extrusion of composite filaments using two techniques of wet spinning and 3D printing. Hydrogels such as oxidized alginate (ADA) and methacrylated gelatin (GelMA) were used as matrices. In the computational simulation, a combination of computational fluid dynamics and coarse-grained molecular dynamics was used to study the dynamics of rod-like fillers in the flow field of a syringe. It showed that, during the extrusion process, microrods are far from being well aligned. Instead, many of them tumble on their way through the needle leading to a random orientation in the fiber which was confirmed experimentally.
Kisspeptin Suppresses Inflammasome-NLRP3 Activation and Pyroptosis Caused by Hypothyroidism at the Maternal-Fetal Interface of Rats

Gestational diseases such as preeclampsia and gestational diabetes cause inflammasome activation and pyroptosis in the placenta and changes in placental kisspeptin levels. Although maternal hypothyroidism also reduces the kisspeptin/Kiss1R system at the maternal-fetal interface, there is still no information on whether this dysfunction causes inflammasome activation and pyroptosis in the placenta or influences the modulatory role of kisspeptin in these processes. This study aimed to evaluate whether hypothyroidism activates the inflammasome-NLRP3 pathway and pyroptosis at the maternal-fetal interface of rats and whether kisspeptin can modulate these processes. Hypothyroidism was induced in Wistar rats by the administration of propylthiouracil. Kisspeptin-10 (Kp10) treatment began on the 8th day of gestation (DG). Gene and/or protein expressions of NLRP3, Caspase 1, IL-1β, IL-18, and Gasdermin D (Gsmd) were evaluated in the deciduae and placentae at the 18th DG. Hypothyroidism increased the decidual and placental stainings of NLRP3, IL-1β, and Gasdermin D, and increased the gene expressions of Nlrp3, Ilβ, and Il18 in the placenta and of Gsmd in the decidua. Treatment with Kp10 suppressed the increase in NLRP3/Nlrp3, IL-1β, Il18, and Gasdermin D/Gsmd caused by hypothyroidism at the maternal-fetal interface. However, Kp10 increased the placental gene expressions of Casp1 and Il1β. The findings demonstrated that maternal hypothyroidism activated the inflammasome-NLRP3 pathway and pyroptosis at the maternal-fetal interface of rats and that treatment with Kp10 was able to block these processes, thus suggesting that kisspeptin analogues may be promising in the treatment of gestational diseases that involve inflammasome activation and pyroptosis.
Three-wave coupling coefficients for MHD plasmas

By reconsidering the general theory for the resonant interaction of three waves in a plasma, we find explicit expressions for the coupling coefficients for three MHD waves. In particular we demonstrate that the interaction between two magnetosonic waves and one Alfvén wave, as well as the interaction between two Alfvén waves and one magnetosonic wave, can be described by very simple formulae for the coupling coefficients.
A Variational Method and Approximations of a Cauchy Problem for Elliptic Equations

A Cauchy problem for general elliptic second-order linear partial differential equations in which the Dirichlet data in H1/2(Γ1 U Γ3) is assumed available on a larger part of the boundary Γ of the bounded domain Ω than the boundary portion Γ1 on which the Neumann data is is investigated using a conjugate gradient method. We obtain an approximation to the solution of the Cauchy problem by minimizing a certain discrete functional and interpolating using the finite diference or boundary element method. The minimization involves solving equations obtained by discretising mixed boundary value problems for the same operator and its adjoint. It is proved that the solution of the discretised optimization problem converges to the continuous one, as the mesh size tends to zero. Numerical results are presented and discussed.
Effect of varieties and harvesting time on yield, chemical composition, and quality of a product similar to chips produced from Jerusalem artichoke

Jerusalem artichoke is grown in different regions and is widely consumed as food. It has a distinct flavor, and, it is an excellent source of inulin, plant, phytochemicals, and some functional nutritional ingredients including dietary fiber and minerals. This study was conducted to assess the effect of varieties and harvest time at 240 and 270 days after planting (December 15 and January 15) respectively, on the total yield of tubers ton /fed as well as kg/plant, average tubers weight, and chemical composition. Also, to test the possibility of producing chips from two varieties of Jerusalem artichoke at two harvest times, frying at different temperatures degrees (170°C, 180°C) and using some technological treatments. The chemical composition of raw materials, processed chips, organoleptic changes, color parameters, and hardness values of the final product were studied. The obtained results showed that the Fuseau variety and the second harvest time were better in terms of the total yield of tubers, the average tuber weight, chemical components, and the production of chips than the Balady variety. It can also be concluded that treatment No. 4 (in which the slices were soaked in a solution containing 2% acetic acid and 1% citric acid), especially, at a temperature of 180 °C, was the best in preserving many important components, as well as imparting distinctive color properties. In addition, this treatment led to improve sensory quality characteristics based on the sensory evaluation of the majority of panelists. Hence, Jerusalem artichoke chips are recommended as snack foods.
Convexité, complête monotonie et inégalités sur les fonctions zêta et gamma, sur les fonctions des opérateurs de Baskakov et sur des fonctions arithmétiques

Résumé Nous prouvons un encadrement optimal pour la quantité $H\left( x,\,s \right)\,=\,\sum{_{n\ge 1}\,\frac{1}{{{\left( x+n \right)}^{s}}}}$ pour $x\,\ge \,0$ et $s\,>\,1$ , qui améliore l'encadrement standard par des intégrales. Cet encadrement entraîne des inégalités sur la fonction $\zeta $ de Riemann, et amène à conjecturer la monotonie de la fonction $s\,\mapsto \,{{[(s\,-\,1)\text{ }\! \! \zeta\! \! \text{ (}s\text{)}]}^{\frac{1}{S-1}}}$ . On donne des applications à l'étude de la convexité de fonctions liées à la fonction $\Gamma $ d'Euler et à la majoration optimale des fonctions élémentaires intervenant dans les opérateurs de Baskakov. Puis, nous étendons aux fonctions complètement monotones sur ] $0,\,+\infty $ [ les résultats établis pour la fonction $x\,\mapsto \,{{x}^{-s}}$ , et nous en déduisons des preuves élémentaires du comportement, quand $z$ tend vers 1, des séries génératrices de certaines fonctions arithmétiques. Enfin, nous prouvons qu'une partie du résultat se généralise à une classe de fonctions convexes positives décroissantes.
Genetic Variability, Principle Components and Cluster Analysis of Twenty-eight Egyptian Wheat Genotypes

Wheat is Egypt's main cereal crop and the foundation of its food security. During two consecutive seasons (2018/2019 and 2019/2020), twenty-eight wheat landraces were cultivated on the farm of Bahteem Research Station, Giza, Egypt, to evaluate their genetic variability and to determine genetic relationships among these evaluated genotypes using cluster analysis and principal components analysis. Across the two seasons, the genotypes investigated differed significantly (P≤0.0.01) for all agronomic characteristics and high assessments of the broad sense heritability were noted for all traits. The data were classified into three major components using principal components analysis. The eigenvalues of the first two were greater than one. These three major components described 76.21% of the total variability in wheat genotypes, while the other five components described only 23.79% of the variation. The cluster analysis divided all genotypes into six groups. The first cluster had three genotypes, accounting for 10.71% of all genotypes. Six genotypes, accounting for 21.43% of all genotypes, were categorized as belonging to the second cluster. The third cluster was also assigned six genotypes, accounting for 21.43 percent of all genotypes. Only one genotype (G5), accounting for 3.57 percent of all genotypes, was identified as belonging to the fourth cluster. Seven genotypes were found in the fifth cluster whereas five genotypes were found in the sixth cluster. Clusters II and IV had the greatest distance between them, followed by Clusters III and IV. Crossing between these clusters may lead to more efficient and superior recombinant wheat improvement programs.
A dawn‐dusk density asymmetry in Earth's magnetosheath

Magnetosheath data from IMP 8 and solar wind data from ISEE 1, ISEE 3, and WIND are used to investigate Earth's magnetosheath structure. Magnetosheath data are transformed into a coordinate system which allows data from regions with similar physical histories to be binned together. The results show a significant dawn-dusk asymmetry in Earth's magnetosheath near solar maximum but not near solar minimum, with larger densities on the dawnside than on the duskside. We use a magnetohydrodynamic (MHD) simulation to model the Parker spiral interplanetary magnetic field (IMF) case; an asymmetry does develop in the same sense as observed in the data but with a somewhat smaller magnitude. Near solar minimum the observed density asymmetry is dependent on the IMF orientation, but this is not true near solar maximum, apparently ruling out both foreshock effects and different compressions/deflections by parallel and perpendicular shocks as causes. Earth's magnetosphere thus could be a contributor to this effect.
Impact of pharmacist‐led discharge medication reconciliation at an Academic Medical Center

Prior studies evaluating the impact of pharmacist‐led discharge medication reconciliation have demonstrated higher rates of medication discrepancy detection and intervention with variable effects on hospital readmission. The purpose of this study was to evaluate the impact of a newly developed pharmacist‐led hospital discharge medication reconciliation process implemented with an interdisciplinary Internal Medicine Service. This was a retrospective, single‐center, pre‐post observational cohort study. Institutional review board approval was obtained. The primary end point was quantification and categorization of medication discrepancies identified on the hospital discharge medication list. Secondary end points included characterization of interventions made during the discharge medication reconciliation process, and 30‐day hospital readmission rates that were adjusted using a multivariable logistic regression model. A total of 144 patients were included in the pharmacist‐led discharge medication reconciliation intervention group and 144 patients were included in the historical control. There was a statistically significant four‐fold reduction in the number of medication discrepancies identified on discharge medication lists in the intervention group (77 vs. 18 in the historical control vs. intervention groups, respectively; p < 0.0001). When adjusted for length of stay (L), acuity of the admission (A), comorbidity of the patient (C), and emergency department use in the last 6 months (E) (LACE) index and age, the adjusted odds ratio (aOR) for 30‐day readmission was 0.51 (95% confidence interval: 0.27–0.95) in the intervention versus the historical control group. Implementation of an interdisciplinary pharmacist‐led discharge medication reconciliation program was associated with a significant reduction in medication discrepancies on the discharge medication list, as well as a reduction in the adjusted odds of 30‐day hospital readmission.
Families of Thue Inequalities with Transitive Automorphisms

A family of parameterized Thue equations is defined as F{t,s,. }(X, Y ) = m, m ∈ Z where F{t,s,. }(X, Y ) is a form in X and Y with degree greater than or equal to 3 and integer coefficients that are parameterized by t, s, . ∈ Z. A variety of these families have been studied by different authors. In this thesis, we study the following families of Thue inequalities |sx − txy − (t+ 3s)xy − sy| ≤ 2t+ 3s, |sx − txy − 6sxy + txy + sy| ≤ 6t+ 7s, |sx − 2txy − (5t+ 15s)xy − 20sxy + 5txy +(2t+ 6s)xy + sy| ≤ 120t+ 323s, where s and t are integers. The forms in question are “simple”, in the sense that the roots of the underlying polynomials can be permuted transitively by automorphisms. With this nice property and the hypergeometric functions, we construct sequences of good approximations to the roots of the underlying polynomials. We can then prove that under certain conditions on s and t there are upper bounds for the number of integer solutions to the above Thue inequalities.
A Network Formation Game with Private Information

In this paper, we introduce private information about link values in the basic network formation game based on link announcements from Myerson (1991) and CalvoArmengol and Ilkilic (2009). We characterize a family of symmetric cut-o equilibria that provides a microfundation for Erdfis-Renyi random networks. We also look at dierent distributional assumptions and asymmetric equilibria that give rise to random networks with dierent probability distributions. Finally, we advance extensions of the concepts of strong eciency and pairwise stability to random networks.
STABILITY OF HALF-LINEAR NEUTRAL STOCHASTIC DIFFERENTIAL EQUATIONS WITH DELAYS

Abstract In this paper, we study the mean square asymptotic stability of a generalized half-linear neutral stochastic differential equation with variable delays applying fixed point theory. An asymptotic mean square stability theorem with a necessary and sufficient condition is proved, which improves and generalizes some results due to Burton, Zhang and Luo. Two examples are given to illustrate our results.