Miracle-dz/UniFAR-FTUs huggingface dataset:
An Explorative Investigation of Intraday Trading on the German Stock Market

The paper contains an intraday study of the German stock market. Using descriptive statistics for interval and transaction returns, volatilities, and transaction frequencies we try to identify the impact of market structure, information (cid:13)ow, and the overnight trading halt on the behavior of prices and volumes. A very interesting feature of the German stock market in this context is that there are two parallel trading systems ((cid:13)oor trading and computer trading) for the group of the most liquid stocks. The results of the analysis for the (cid:13)oor market are consistent with the (cid:12)ndings of previous studies for other markets in that we also (cid:12)nd a U-shaped pattern for transaction frequency and volatility. Intraday return volatility does not seem to be related to the mechanism of price determination (batch trading or continuous trading). However, there seems to be an e(cid:11)ect of the noon auction on the direction of price changes. For the computerized market we do not observe such clear patterns. Furthermore, the (cid:12)ndings indicate that volatility around the (cid:13)oor opening is mostly induced by information that has accumulated overnight. Although there is computerized trading for two hours before the (cid:13)oor market opens market participants do not seem to consider prices from the computerized system as informative as prices from the (cid:13)oor. Finally, auction prices from the (cid:13)oor seem to contain valuable information for IBIS traders.
Enhancement of the protective e⁄cacy of an oprF DNA vaccine against Pseudomonas aeruginosa

The outer membrane protein F gene ( oprF ) of Pseudomonas aeruginosa was recently shown by us to protect mice from P. aeruginosa chronic pulmonary infection when used as a DNA vaccine administered by three biolistic (gene gun) intradermal inoculations given at 2-week intervals. In the present study, we used two different strategies to improve the protective efficacy of the DNA vaccine. In the first strategy, mice were primed with two biolistic intradermal inoculations with the oprF vaccine and then were given a final intramuscular booster immunization containing either a synthetic peptide^keyhole limpet hemocyanin (KLH) conjugate or a chimeric influenza virus. Both the synthetic peptide conjugate and the chimeric virus contained peptide 10, a previously identified immunoprotective epitope of protein F. The second strategy involved the addition of a second outer membrane protein to the vaccine. DNA encoding a fusion protein comprised of the C-terminal half of protein F fused to OprI was administered by three biolistic intradermal inoculations. Challenge with P. aeruginosa in a chronic pulmonary infection model demonstrated that boosting with the chimeric virus (but not with peptide^KLH) or adding oprI to the DNA vaccine significantly enhanced protection as compared to that afforded by the oprF vaccine given alone. Thus, both strategies appear to augment the protection afforded by an oprF -only DNA vaccine. 9 2002 Federation of European Microbiological Societies. Published by Elsevier Science B.V. All rights reserved.
Phonological processing in children with speech disorders

This study investigates the output phonological processing of children with phonological disorder and delay and asks whether different processing deficits underlie different speech disorders. The study compares the speech errors of two groups of children on four tasks: naming, repetition of sentence, repetition of non-words and words. These tasks arguably tap different levels of output processing. Result indicates a significantly higher percentage of phonemic errans for the phonological disorder group than the delay group. Both groups performed similarly across the four tasks. The implications for the levels of impairment in the two groups are discussed in terms of Hewlett's (1990) model of phonological processing and future therapeutic intervention is considered.
dynamics and real marginal costs: new evidence from manufacturing industries

This paper deals with the analysis of price-setting in U.S. manufacturing industries. Recent studies have heavily criticized the ability of the New Keynesian Phillips curve (NKPC) to (cid:133)t aggregate in(cid:135)ation [see, e.g., Rudd and Whelan, 2006, Can Rational Expectations Sticky-Price Models Explain In(cid:135)ation Dynamics? , American Economic Review, vol. 96(1), pp. 303-320 ]. We challenge this evidence, showing that forward-looking behavior as implied by the New Keynesian model of price-setting is widely supported at the sectoral level. In fact, current and expected future values of the income share of intermediate goods emerge as an e⁄ective driver of in(cid:135)ation dynamics. Unlike alternative proxies for the forcing variable, the cost of intermediate goods presents dynamic properties in line with the predictions of the New Keynesian theory. we also report the number of sectors for which the sectoral estimates are signi(cid:133)cant and present the sign predicted by the theory. This means that for the purely forward-looking speci(cid:133)cation we report the number of sectors for which ^ (cid:13) i is positive and signi(cid:133)cant. For the hybrid version of the model with ’ (cid:20) 1 = 2 we report the number of sectors for which both ^ (cid:21) 1 i and ^ (cid:21) 2 i are positive and statistically signi(cid:133)cant. Finally, for the hybrid version with ’ > 1 = 2 we report the number of sectors for which ^ (cid:22) 1 i is signi(cid:133)cant and positive, while for ^ (cid:22) 2 i we report the number of cases in which it is signi(cid:133)cantly di⁄erent from zero, regardless of its sign. The total number of sectors is 458, with 187 sectors producing non-durables and 253 sectors involved in the production of durables.
Affect of child factors on the sibling relationship of normal child with mentally challenged sibling

Ninety siblings of children with mental retardation and their parents from urban and rural areas of selected districts of Northern Karnataka and special schools for mentally retarded located in Hubblli- Dharwad city comprised the population for the study. Sibling relationship Questionnaire (SRQ) (Furman Buhrmester, 1990) was used to assess the typical sibling’s perceptions of the relationship and behaviors towards their sibling with related child factors. Results reveled that among children with 13-18 year age group almost all had moderate level of sibling relationship. In case of 5-12 years age group majority of them were in moderate level of sibling relation and some were in low level of sibling relation. All first borns had moderate level of sibling relation and in case of second and later born, majority were in moderate level of sibling relation followed by low level of sibling relation. In case of children with mild and moderate level of retardation, had moderate and low level of sibling relationship. In case of profound mental retardation half of the children had low level of sibling relation. Level of retardation showed non-significant association in rural area. In case of urban area the level of retardation showed significant association with sibling relationship.
Title : RAPTOR controls developmental growth transitions by altering 7 the hormonal and metabolic balance 8 9

the hormonal and metabolic balance 8 9 Mohamed A. Salem, Yan Li, Krzysztof Bajdzienko, Joachim Fisahn, Mutsumi 10 Watanabe, Rainer Hoefgen, Mark Aurel Schöttler and Patrick Giavalisco * 11 Max Planck Institute of Molecular Plant Physiology, Am Mühlenberg 1, 14476 Potsdam12 Golm, Germany. 13 Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, 14 Cairo 11562, Egypt. 15 * Current address: Max Planck Institute for Biology of Ageing, Joseph Stelzmann Str. 9b, 16 50931 Cologne, Germany 17 18 Mohamed A. Salem (Salem@mpimp-golm.mpg.de) 19 Yan Li (Li@metasysx.eu) 20 Krzysztof Bajdzienko (Bajdzienko@mpimp-golm.mpg.de) 21 Joachim Fisahn (Fisahn@mpimp-golm.mpg.de) 22 Mutsumi Watanabe (Watanabe@mpimp-golm.mpg.de) 23 Rainer Hoefgen (Hoefgen@mpimp-golm.mpg.de) 24 Mark Aurel Schöttler (Schoettler@mpimp-golm.mpg.de) 25 Patrick Giavalisco (Giavalisco@age.mpg.de) 26 27
Transcriptional regulation of the human cytochrome P450 2A6 ( CYP2A6 ) gene 1

Nicotine C -oxidation is primarily catalysed by cytochrome P450 2A6 in humans. This enzymatic activity exhibits a large interindividual variability, which to a great extent is caused by genetic polymorphisms in the CYP2A6 gene. There are large interindividual differences in CYP2A6 mRNA and protein levels but little is known about the transcriptional regulation of CYP2A6 which can e.g. explain such differences. Using transient transfections of 5’-deleted CYP2A6 promoter constructs in human hepatoma B16A2 cells, we show that maximal promoter activity was harboured in the sequence spanning from − 112 to − 61. Putative response elements for the transcription factors HNF-4 α , C/EBP α , C/EBP β and Oct-1 were identified in this region, and electrophoretic mobility shift assays showed that these transcription factors bind to the predicted elements. To determine the relevance of these sites, expression vectors for these transcription factors were co-transfected with CYP2A6 promoter constructs in HepG2 cells. HNF-4 α , C/EBP α and Oct-1 exerted an activating effect, whereas overexpression of C/EBP β reduced CYP2A6 promoter activity. To confirm the importance of these sites in vivo , mutated CYP2A6 reporter constructs were injected into mouse liver. Mutation of either HNF-4 or C/EBP-Oct-1 motifs significantly decreased promoter activity, 52 and 26% of wild-type, respectively, whereas when both motifs were mutated the activity in mice decreased to 14% of wild-type. In conclusion, the data indicate that the constitutive hepatic expression of CYP2A6 is governed by an interplay between the transcription factors HNF4- α , C/EBP α , C/EBP β and Oct-1. These results will be important for the identification of new polymorphisms affecting CYP2A6 gene expression. activity, the identified is not to a great extent, in CYP2A6 induction and CYP2A6
THE EFFECT OF THE ENVIRONMENT ON PROBLEM BEHAVIOUR The effect of the environment on problem behaviour: The role of school culture in secondary schools in The Hague Master thesis

According to the socio-ecological theory the environment has an impact on student’s problem behaviour. Research demonstrates that on individual level, the socioeconomic status of the student is of profound influence. It has also been suggested that for European students, the neighbourhood surrounding the school could be important and consequently meaningful in explaining problem behaviour. Furthermore the social context, in which these factors are experienced, influences its impact on student’s behaviour. Therefore present study proposes a mediation model linking the socioeconomic status of the student and the school environment to problem behaviour and examining the role of school culture to this relation. To test this model, students from three different schools in The Hague were asked to fill in questionnaires and information about the school environment was collected. The results did not support the mediation model. Although negative school culture was related to more problem behaviour, differences in problem behaviour outcome between students were not explained by socioeconomic status or school environment. Moreover, differences between schools were of incremental value when taking into account school culture. Explanations and implications of these results are discussed.
Cholesterol-lowering effect of (cid:2) -glucan from oat bran in mildly hypercholesterolemic subjects may decrease when (cid:2) -glucan is incorporated into bread and cookies 1–3

Background: Findings about the effects of (cid:2) -glucan on serum lipoproteins are conflicting. Objective: The study investigated the effects of (cid:2) -glucan from oat bran in bread and cookies (study 1) and in orange juice (study 2) on serum lipoproteins in mildly hypercholesterolemic subjects. Design: In study 1, 48 subjects (21 men, 27 women) received for 3 wk control bread and cookies rich in wheat ﬁber. For the next 4 wk, by random assignment, 23 subjects continued to consume the control products, and 25 received bread and cookies rich in (cid:2) -glucan. Mean daily intake of (cid:2) -glucan was 5.9 g. Total dietary ﬁber intake did not differ signiﬁcantly between the groups. In study 2, the same sources of control ﬁber and (cid:2) -glucan (5 g/d) as in study 1 were provided. For 2 wk, 25 of the original 48 subjects (10 men, 15 women) were randomly assigned to consume orange juice containing either wheat ﬁber ( n = 13) or (cid:2) -glucan from oat bran ( n = 12). After a washout period of 1 wk, dietary regimens were crossed over. Results: In study 1, the change in LDL cholesterol did not differ significantly ( (cid:3) 0.12 mmol/L; P = 0.173) between the 2 groups. In study 2, the drink rich in (cid:2) -glucan decreased LDL cholesterol by 0.26 ± 0.07 mmol/L (6.7 ± 1.8%; P = 0.001) and the ratio of total to HDL cholesterol by 0.26 ± 0.11 (5.4 ± 2.1%; P = 0.029) compared with the other drink. HDL-cholesterol and triacylglycerol concentrations did not change significantly. Conclusions: The food matrix or the food processing, or both, could have adverse effects on the hypocholesterolemic properties of oat (cid:2) -glucan. Am J Clin Nutr 2003;78:221–7.
LIPID ABNORMALITIES IN NON-DIABETIC, NON-OBESE AND PATIENTS OF HYPERTENSION

: Background: Dyslipidemia and hypertension are among the main contributors to the pathogenesis of coronary artery disease, and their coexistence does not increase the risk, but rather increases it. OBJECTIVE: The aim of this study was to determine the frequency of dyslipidemia in non-obese, non-diabetic hypertensive patients and to compare it with the same frequency in non-obese, non-diabetic, normotensive patients. Methods: This case-control study was conducted in the Department of Medicine, Khyber Teaching Hospital Peshawar for six months duration from January 2021 to June 2021. 120 adults of both sexes were included in the study; 40 non-obese, non-diabetic, hypertensive patients and 80 non-obese, non-diabetic, normotensive individuals. Demographic data and eating habits of each subject were recorded using a questionnaire. Fasting lipid profile and blood glucose of all subjects were evaluated. All data were compared between the two groups. Results: The hypertensive group showed higher total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and triglycerides (TG), and lower high-density lipoprotein cholesterol (HDL-C) values compared to the hypertensive group. Normo-tensive group. In males only, TC, LDL-C, HDL-C abnormalities and TG were more common in the hypertensive group (odds ratio = 2.96, 2.67, 4.28 and 4.57), respectively. HDL-C abnormality in women was similar in both groups (odds ratio = 1.47). Conclusion: Hypertensive individuals are more likely to have various lipid abnormalities such as total cholesterol, LDL-C, HDL-C (men), and triglycerides compared to the normotensive population.
Intramedullary Nailing of Femur Fractures in the Obese: A Retrospective Comparison of Patients with Normal Weight versus the Obese

Objectives: To compare retrograde and antegrade intramedullary nailing in obese patients at a single level one trauma center relative to normal and overweight patients with respect to perioperative variables. Design: Single center retrospective review. Setting: University medical center (level one trauma center). Patients/Participants: A total of 121 consecutive patients were studied (84 in the antegrade group and 37 in the retrograde group) with breakdown of 46 normal weight, 39 overweight, and 36 obese. Intervention: Antegrade and retrograde intramedullary nailing of femoral shaft fracture. Main Outcome Measurements: Patient and fracture characteristics, prep time, operative time, fluoroscopy time, and estimated blood loss were evaluated. Results: Statistical differences were only in the antegrade group where increasing body mass index was related to average increase in prep time (10 minutes; P = 0.08), operative time (56 minutes; P = 0.0003), and estimated blood loss (80 mL; P = 0.08). An increase in body mass index of 2 kg/m 2 for the antegrade group was associated with a mean increase of 1.2 minutes prep time, 5.9 minutes operative time, and 7.5 mL estimated blood loss. Retrograde group values were 1.9 minutes, 1.2 minutes, and 7.4 mL, respectively. Conclusion: Obese patients had statistically higher operative times for antegrade intramedullary nailing while retrograde intramedullary nailing permits easier percutaneous execution and indirect reduction resulting in a decreased operative time.
No effect of 25 mg oxazepam on physiological and self-rated responses to pain in others: a randomized controlled experiment

Background: Benzodiazepines have been proposed to inhibit empathic responding to others’ pain. Aims: We aimed to investigate the effect of 25 mg oxazepam on self-rated experience, skin conductance, heart rate, and superciliary corrugator muscle activity when observing another person in pain. Methods: In a double-blind randomized controlled experiment, participants were given 25 mg oxazepam or placebo and then pain stimulated with electrical shocks, alternately with another person whom they thought was a fellow experimental participant. Results: Oxazepam did not cause increased responses to others’ pain, compared to participants’ own pain, on any of the measures used. Oxazepam did cause increased ratings of unpleasantness and increased skin conductance responses across conditions. Empathic responses were predicted by self-rated empathy using the interpersonal reactivity index and inversely predicted by self-rated alexithymia using the Toronto Alexithymia Scale-20. Conclusions: Oxazepam did not inhibit empathic responding in this experiment. Oxazepam did cause a general increase in self-rated unpleasantness and skin conductance responses.
CMAR_A_255817 6149..6163

1Guangdong Provincial Institute of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, People’s Republic of China; 2Department of Urology, Guangdong Key Laboratory of Clinical Molecular Medicine and Diagnostics, Guangzhou First People’s Hospital, Guangzhou Medical University, Guangzhou 510180, People’s Republic of China; 3Department of Urology, Guangdong Key Laboratory of Clinical Molecular Medicine and Diagnostics, Guangzhou First People’s Hospital, School of Medicine, South China University of Technology, Guangzhou 510180, People’s Republic of China; 4Urology Key Laboratory of Guangdong Province, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou 510230, People’s Republic of China; 5Department of Urology, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong 510632, People’s Republic of China; 6School of Medicine, Jinan University, Guangzhou, Guangdong 510632, People’s Republic of China
LETTERS TO THE EDITOR Atrial Natriuretic Factor and Digoxin-Like Immunoreactive Factor in Diabetic Patients: Their Interrelation and the Influence of the Autonomic Nervous System

In a paper published in JCEM, Straub et al. (1) reported on the interrelations in diabetics between atrial natriuretic factor (ANF), endogenous digoxin-like immunoreactive factors (DLIF), and autonomic abnormalities. The authors state that “a group of natriuretic hormones such as ouabain or DLIF play an important role in the hormonal feedback system to control volume expansion” and that “DLIF is secreted from the adrenal glands and hypothalamus,” and they conclude that their results “demonstrate close interactions between the autonomic nervous system and the two natriuretic hormones” (DLIF and ANF) and that in diabetics with autonomic dysfunction “higher levels of ANF may possibly compensate for the lack of the natriuretic DLIF” (1). We think that the paper conveys an unjustified impression of established knowledge in an area that still requires great caution, and we feel compelled to comment and amend a few imprecisions in the article.
Plasma Glucose Levels of Asthma Patients Using Inhaled Fluticasone

Md. Atikur Rahman Bangabandhu Sheikh Mujib Medical University Md. Nazmul Hasan Bangabandhu Sheikh Mujib Medical University Md. Abdur Rahim Bangabandhu Sheikh Mujib Medical University Shamim Ahmed Bangabandhu Sheikh Mujib Medical University Salina Parvin Munni Bangabandhu Sheikh Mujib Medical University Mihir Kanti Adhikari General Hospital, Habiganj Muhammad Jamal Uddin General Hospital, Noakhali KM Saif-Ur-Rahman (  s.rahman2312@yahoo.com ) International Centre for Diarrhoeal Disease Research Bangladesh https://orcid.org/0000-0001-87027094
The Relationship Between Human Papillomavirus, OFD1 and Primary Ciliogenesis in the Progression of Oropharyngeal Cancer: A Retrospective Cohort Study

Purpose: Infection with human papillomavirus (HPV) has been indicated to be a important risk factor for oropharyngeal squamous cell carcinoma (OPSCC). Primary ciliogenesis defects contribute to tumorigenesis, and OFD1 at centriolar satellites is a crucial suppressor of primary ciliogenesis. To identify novel markers associated with HPV-induced carcinogenesis, the interactions between HPV infection and primary ciliogenesis in the tumorigenesis and progression of OPSCC were investigated in this study. Patients and Methods: The 1530 OPSCC patients recruited in this research were treated from 2000 to 2017. Immunohistochemistry and RT-PCR were performed on tissue samples to compare the expression of p16, TSLP, TGFβ1, IFNγ, OFD1, and their relationship with clinical characteristics of patients. Results: We speculate that the positive expression of p16 is related to early primary OPSCC, and the survival rate of p16 positive patients after radiotherapy and surgery is higher. Expression of TSLP on dendritic cells in HPV-positive OPSCC correlated with the expression of OFD1. HPV-positive OPSCC showed increased expression of OFD1 combined with reduced ciliogenesis. Hence, TSLP induced by HPV infection may reduce the invasive potential of OPSCC cells by promoting OFD1 expression, thereby inhibiting primary ciliogenesis. Conclusion: Our study demonstrated that HPV may be related to the progression of OPSCC by regulating OFD1 expression and primary ciliogenesis, making this protein a potential therapeutic target.
Diagnostics as a Hybrid Reasoning Processes: from Logic Model to Software design

Diagnostic tests are used to determine anomalies in complex systems such as organisms or built structures. Once a set of tests is performed, the experts interpret their results and make decisions based on them. This process is named diagnostic reasoning . It is a process in which a decision is established that uses rules and general knowledge on the tests and the domain. The artificial intelligence community has focused on devising and automating different methods of diagnosis for medicine and engineering, but, to the best of our knowledge, the decision process in logical terms hasn’t yet been investigated thoroughly. The automation of the diagnostic process would be helpful in a number of contexts, in particular when the number of test sets to make decision is too wide to be dealt with manually. To tackle such challenges, we shall study logical frameworks for diagnostic reasoning, automation methods and their computational properties and technologies implementing these methods. In this paper, we present the formalization of a hybrid reasoning framework T L that hosts tests and deduction rules on tests, and an algorithm that transforms a T L theory into defeasible logic, for which an implemented automated deduction technology (called Spindle) exists. We evaluate the methodology by means of a real-world example related to the Open Web Application Security Project requisites. The full diagnostic process is driven from the definition of the issue to the decision.