Miracle-dz/UniFAR-FTUs huggingface dataset:
Risk Factors of Patent Ductus Arteriosus in Preterm

Patent Ductus Arteriosus (PDA) is one of acyanotic congenital heart diseases that often occurs in preterm infants and closely related to an increased risk of complications for sufferers. Identification of PDA risk factors in preterm infants is very important, so that the diagnosis and management can be done earlier. In this study we aimed to determine risk factors of PDA in preterm infants. This case-control study was conducted between July 2017 and April 2018, analysed 43 preterm infants with PDA as the case group and 43 preterm infants without PDA as the control group. The basic information related to characteristics, risk of infection and perinatal history in both groups were collected. Bivariate and multivariate analysis with logistic regression were performed to identify risk factors for PDA. We found several factors were identified significantly (P 12 hours (OR 7.25; 95% CI: 2.08 - 25.09) and thrombocytopenia in the first 24 hours (OR 15.11; 95% CI: 3.73 - 61.13). This study concluded premature rupture of membranes >12 hours and thrombocytopenia in the first 24 hours were proven to increase the risk of PDA in preterm infants.
Increases in adipose and total body weight, but not in lean body mass, associated with subcutaneous administration of Sonic hedgehog‐Ig fusion protein to mice

Sonic hedgehog (Shh) is a member of a family of proteins that are involved in embryonic development. The receptor signaling pathways for Shh persist in adults and stimulation of this pathway has shown therapeutic efficacy in animal models of neurodegeneration/regeneration. This study was conducted to evaluate the safety of repeat dose administration of an IgG fusion protein of Shh (Shh‐Ig) in adult mice. Routine toxicology evaluations were performed. In addition, body composition analysis was conducted by densitometry. Shh‐Ig treatment caused a significant increase in body weight gain relative to controls and a slight increase in liver and spleen weights. The increase in body weight could be largely accounted for by an increase in body fat. The treatment‐related increases in body weight were reversible upon cessation of treatment. Shh‐Ig treatment produced no significant changes in clinical chemistry or hematology. There were no gross or histomorphologic findings in any tissue except for skin and spleen. Microscopic findings in the skin were limited to minimal to slight local epidermal hyperplasia at the sc injection site and increased thickness of the fat layer. In the spleen a slight increase in extramedullary hematopoiesis was seen. This finding is possibly a secondary response following inflammation at the injection site in some animals due to the administration of a foreign protein. This study showed that Shh‐Ig administration was well tolerated. The most significant finding was a reversible increase in body weight. Drug Dev. Res. 57:107–114, 2002. © 2002 Wiley‐Liss, Inc.
Average Real Variability of Diastolic Blood Pressure During Acute Phase Could Independently Predict 3-month Functional Outcome for Ischemic Stroke

Background and purpose-Blood pressure variability has a significant effect on stroke. There were controversial reports about its relationship with short term functional outcome remains controversial for ischemic stroke or transient ischemic attack (TIA). There were limited studies about its long-term effect. Our aim was to elucidate the effect of BPV on a 3-month functional outcome in patients with acute ischemic stroke or TIA. Methods—In this prospective observational study, a consecutive series of 400 patients were enrolled with acute ischemic stroke or TIA within 7 days. All patients were referred and monitored for BP at 2-hour intervals in the first 24 hours. Afterward, the BP was recorded every four hours up to the 7th day, with 1-hour deviation the daytime and 2 hours at night. All BP results were recorded into an electronic medical record (EMR) system. Average real variability (ARV) was used to analyze the blood pressure variability (BPV). All patients were followed up as planned for 90 days. The primary outcome was evaluated by the modified Rankin Scale (mRS); an unfavorable outcome was mRS≥2. For comparison, patients were respectively divided into two groups based on systolic blood pressure ARV (SBP ARV) or diastolic blood pressure ARV (DBP ARV). A multivariate logistic regression model was used to estimate the effect of between ARV BPV on functional outcomes. Results-Among the 400 patients, 46 (11.4%) had an unfavorable outcome (mRS>2) at 90 days. Their mean 24h DBP ARV was significantly higher than others (10.42±3.63 vs. 9.83±4.27 mm Hg; p=0.03). The high 24hDBPARV was defined above the median of 7.75 mmHg, which was statistically associated with an unfavorable outcome (64.7% vs. 35.3%; P=0.004). Further stepwise logistic regression analysis indicated that 24h high DBPARV was the independent predictor of an unfavorable outcome (adjusted OR 2.44%, 95% confidence interval: 1.24-4.74, P<0.01). Conclusions—High DBPARV during the acute phase is an independent and significant predictor of 90-day functional outcome for ischemic stroke or TIA.
Structural and functional consequences of switching carboxy terminal domains in mouse CD200 receptors

CD200:CD200R interactions regulate immune responses. Since CD200Rs show extensive homology in their extracellular region, generating anti-CD200R specific antibodies is a challenge. We report below on the generation of mAbs specific for murine (m)R1/R2 and evidence that mR2 is expressed on the cell surface in the absence of the adaptor protein Dap12. Despite homology between mR1 and mR4, the unexpected reduction in the molecular mass (i.e. 90kDa vs 48kDa) between the two receptors suggested that the TM and cytoplasmic region of mR4 regulated glycosylation. Substitution of the TM and cytoplasmic region of mR1 and mR2 with that of mR4 reduced glycosylation of the chimeric receptors mR1r4 and mR2r4 implying that these regions regulated the glycosylation of mCD200Rs. In activation experiments, phosphorylation of Dap12 following interaction with CD200 occurred on cells expressing mR2V5 but not mR4V5. Similar experiments with the chimeric receptors mR1r2 and mR1r4 also produced phosphorylation of Dap12. Our data suggest that the TM and cytoplasmic region of mCD200Rs dictate their state of glycosylation and provide further evidence that both mCD200R1 and mCD200R2 bind CD200 as ligand with functional consequences for down-stream signaling.
Particulate-facilitated leaching of glyphosate and phosphorus from a marine clay soil via tile drains

Abstract Losses of commonly used chemical pesticides from agricultural land may cause serious problems in recipient waters in a similar way to phosphorus (P). Due to analytical challenges concerning determination of glyphosate (Gly), transport behaviour of this widely used herbicide is still not well known. The objective of the present study was to quantify and evaluate leaching of Gly in parallel with P. Leaching losses of autumn-applied Gly (1.06 kg ha−1) via drainage water were examined by flow-proportional sampling of discharge from 20 drained plots in a field experiment in eastern Sweden. Samples were analysed for Gly in particulate-bound (PGly) and dissolved (DGly) form. The first 10 mm water discharge contained no detectable Gly, but the following 70 mm had total Gly (TotGly) concentrations of up to 6 µg L−1, with 62% occurring as PGly. On average, 0.7 g TotGly ha−1 was leached from conventionally ploughed plots, compared with 1.7 g TotGly ha−1 from shallow-tilled plots (cultivator to 12 cm working depth). Higher Gly losses occurred in snowmelt periods in spring, but then with the majority (60%) as DGly. All autumn concentrations of PGly in drainage water were significantly correlated (p<0.001) to the concentrations of particulate-bound phosphorus (PP) lost from the different plots (Pearson correlation coefficient 0.84), while PP concentrations were in turn significantly correlated to water turbidity (Pearson correlation coefficient 0.81). Leaching losses of TotGly were significantly lower (by 1.3 g ha−1; p<0.01) from plots that had been structure-limed three years previously and ploughed thereafter than from shallow-tilled plots. Turbidity and PP concentration also tended to be lowest in discharge from structure-limed plots and highest from shallow-tilled plots. This difference in TotGly leaching between soil management regimes could not be explained by differences in measured pH in drainage water or amount of discharge. However, previously structure-limed plots had significantly better aggregate stability, measured as readily dispersed clay (RDC), than unlimited plots. The effects of building up good soil structure, with strong soil aggregates and an appropriate pore system in the topsoil, on mitigating Gly and P losses in particulate and dissolved form should be further investigated.
Stable isotopic composition of carbon and nitrogen and nitrogen content in vascular epiphytes along an altitudinal transect

The foliar content of nitrogen and the relative abundances of 13C and 15N were analysed in vascular epiphytes collected from six sites along an altitudinal gradient from tropical dry forests to humid montane forests in eastern Mexico. The proportion of epiphyte species showing crassulacean acid metabolism (CAM) (atmospheric bromeliads, thick-leaved orchids, Cactaceae, and Crassulaceae) decreased with increasing elevation and precipitation from 58 to 6%. Atmospheric bromeliads, almost all of which had δ13C values indicating CAM, were more depleted in 15N (x=−10·9‰± 2·11) than the C3 bromeliads which form water-storing tanks (−6·05‰± 2·26). As there was no difference in δ15N values between C3 and CAM orchids, the difference in bromeliads was not related to photosynthetic pathways but to different nitrogen sources. While epiphytes with strong 15N depletion appear to obtain their nitrogen mainly from direct atmospheric deposition, others have access to nitrogen in intercepted water and from organic matter decomposing on branches and in their phytotelmata. Bromeliads and succulent orchids had a lower foliar nitrogen content than thin-leaved orchids, ferns and Piperaceae. Ground-rooted hemi-epiphytes exhibited the highest nitrogen contents and δ15N values.
Genetic Analyses of Chinese Cynodon Accessions by Flow Cytometry and AFLP Markers

Bermudagrass [Cynodon dactylon (L.) Pers. ] is widely distributed in China, but little information exists on genetic diversity within the germplasm pool. This study was conducted to assess variations in ploidy and amplified fragment length polymorphisms (AFLPs) among Cynodon accessions collected from 11 Chinese provinces. Flow cytometryandAFLPanalyses were performedon 132 and119 Chinese accessions, respectively. Four ploidy cytotypes were found among the Chinese accessions. Tetraploid (2n 5 4x 5 36) accessions were most prevalent (88%), with nuclear genome sizes ranging from 1.96 to 2.30 pg/2C nucleus 21 . Seven hexaploid (2n 5 6x 5 54), three pentaploid (2n 5 5x 5 45), and six triploid (2n 5 3x 5 27) accessions had respective nuclear genome size of 2.90 to 3.13, 2.37 to 2.49, and 1.55 to 1.65 pg/2C nucleus 21 . The accessions were grouped into five clusters based on 466 polymorphic AFLP bands. Genetic similarity coefficients (GSCs) of two clusters containing ‘Tifway’ and ‘Tifgreen’ ranged from 0.97 to 0.99, suggesting the triploid plants most probably were introduced cultivars from the USA. Within the Chinese indigenous accessions, GSC ranged from 0.65 to 0.99. Tetraploid genotypes had thegreatest geneticvariationwithGSCranging from0.69to0.99,while pentaploids had the least with GSC ranging from 0.95 to 0.98. Genetic differentiation among the later three ploidy levels is evident. Fully sampling the genetic diversity of Cynodon in China will require more comprehensive collection throughout its distribution.
Occupational Stress and Associated Factors among Nurses working in Public Hospitals of Arsi Zone, Oromia Regional State, Central Ethiopia, 2018

Nursing, by its nature, is an occupation subject to a high degree of stress. This profession involves working with people who are themselves suffering a considerable degree of stress. Occupational stress compromised quality of service delivery and also leads as employees’ burnout, turnover and absenteeism. The Objective of the study is to determine the level of occupational stress and associated factors among nurses. The study employed facility based cross sectional study was conducted from August 13 –September 02, 2018. All nurses who served at least for 6 months in Arsi zone public hospitals were asked using self-administered structured questionnaire. The collected data was checked manually, edited, coded and entered into Epi-data version 3.1 and finally it was exported in to statistical package for social science version 24 for cleaning and analysis. Descriptive statistics were used to estimate frequency percent and mean. Dependent variables (occupational stress) were computed based on the respondents having average score of mean and above in expanded nursing stress scale. Then, associations between independent and dependent variables were analyzed first using bivariate binary logistic regression. Variables that had p<0.25 on bivariate binary logistic regression were entered into multivariable binary logistic regression and adjusted odds ratio (AOR) with 95% CI were reported. The study finding showed that 202 (53%) with (95% CI: 48.2-58.1) of nurses were occupationally stressful. Factors significantly associated with occupational stress among nurses were sex of respondents (female: AOR=2.37, 95% CI: 1.41, 3.97), marital status (ever married: AOR=2.49, 95% CI: 1.35, 4.60), Role ambiguity (nurses who had Role ambiguity: AOR=3.01, 95% CI: 1.79, 5.05) and working hours. (≥8hrs hours per day: AOR=2.85, 95% CI: 1.10, 7.36). In this study, more than half of nurses had occupational stress, Thus, Arsi zone public hospitals collaborative with concerned stakeholders to design stress reduction program for tackling occupational stress among nurses.
The effect of essential oils of Zataria multiflora and Mentha spicata on the in vitro rumen fermentation, and growth and deaminative activity of amino acid-fermenting bacteria isolated from Mehraban sheep

Gas (CO2 and CH4) and ammonia production in the rumen represent major sources of lost carbon and nitrogen, respectively. The essential oils of some plants have been shown to decrease gas and ammonia production by selectively inhibiting rumen microbes. Particularly, those of Zataria multiflora (ZEO; thymol 21%, carvacrol 32%) and Mentha spicata (SEO; carvone 55%) were evaluated in vitro as ruminant-feed additives. The experiments employed mixed rumen microbes and a hyper-ammonia-producing bacterium (HAP) isolated from the rumen of a Mehraban sheep. Both ZEO and SEO decreased in vitro fibre digestibility and also gas production by mixed rumen microbes that were fermenting a typical growing-lamb diet. ZEO decreased ammonia concentration in mixed culture of rumen microbes, but SEO exerted the opposite effect. A bacterial isolate (MT8) was obtained from the rumen of a Mehraban sheep, and the 16S rRNA gene sequence indicated that it was most closely related to Clostridium bifermentans. Isolate MT8 exhibited rapid ammonia production when peptides were the growth substrate, which indicated that MT8 was a HAP. Both oils inhibited the growth and ammonia production of isolate MT8. However, ZEO decreased ammonia production at lower doses, and to a greater degree, than did SEO. These results indicated that both essential oils could potentially be used to modulate rumen fermentation. The detrimental effects on fibre digestion could be problematic in high-forage diets, and this requires further investigation. Isolate MT8 is the first described HAP from the Mehraban sheep rumen. Results on ammonia production by isolate MT8 and mixed rumen microbes indicate differential mode of action of each oil on this parameter.
Depoliticisation, Delegation, Leadership: On the Efficient Management of Late-modern Complexity

Advanced modern societies are experiencing a transformation of their politics and style of policy making that may suitably be described as a paradigm change. Over the past decade or so, established European Democracies, have not just been modernising their economic structures and social systems in order to adapt to the necessities of the increasingly globalized economy, but they have, arguably, been caught up in a comprehensive transformation of late-modern democracy. The ‘continuous decline of effectiveness that undermines the confidence of citizens in the democratic regime’ (Roller 2005: 1) has concerned political elites and academic observers for some time. In ‘nearly all advanced industrial democracies’ and ‘by almost any measure, public confidence and trust in, and support for’ the established structures of democracy ‘has eroded over the past generation’ (Dalton 2004: 191). There is evidence suggesting that ‘adherence to the norms and ideals of the democratic process have apparently increased’ (ibid.: 192), but citizens are becoming ever more ‘sceptical towards politicians, political parties, and political institutions’ (ibid.: 191) which are widely perceived as, to put it bluntly, a waste of time. Public debates about the ‘end of democracy’ or even the ‘end of politics’ (Baumann 1999; Gamble 2000; Furedi 2005), but also about the ‘reinvention’ (Beck 1997) or ‘revival of politics’ (Boggs 2000: 243ff) indicate just how intensely the arrival of a turning point in democratic politics is being perceived.
The New World species of Trichomanes sect. Didymoglossum and Microgonium

From the many misidentifications in herbaria and the contradictions between the descriptions of many authors it became evident that the species of Trichomanes included by Desvaux, Presl, van den Bosch and Copeland under the generic name Didymoglossum and those included by Presl, van den Bosch and Copeland under the name Microgonium were particularly poorly understood. A complete revision of this group has never been undertaken. LINDMAN’s paper (1903) is incomplete, being based only on the study of about 30 herbarium sheets; moreover, his conclusions are based on misinterpretation of several species. The treatments in local floras, as, e.g. STURM’s (1859) and MAXON’s (1926) are very good, but only a small number of species are involved. The name Didymoglossum was used for the first time by DESVAUX (1827); it was taken up by PRESL (1843), and COPELAND (1938), all on the generic level. Microgonium was established as a genus by PRESL (1843). Van den BOSCH (1861) and COPELAND (1938) maintened it as a separate genus.
Is fecundity the ultimate cause of female-biased size dimorphism in a dragon lizard?†

Fecundity selection is one of the most influential underlying driving forces responsible for body size differences between the sexes of a species. Reproductive output is one of the most important aspects of an animal's life-history strategy, and any trait that acts to improve this will be under strong selection. Body size is one potential trait that can influence fecundity and when a species exhibits female-biased size dimorphism, fecundity provides an ideal starting point for understanding why dimorphism in body size exists. Female-biased sexual size dimorphism is uncommon in vertebrates, including lizards. To explore the relationship between female-biased size dimorphism and fecundity, we examined maternal size and clutch data collected over four years from a temperate-zone agamid, Rankinia (Tympanocryptis) diemensis. We measured the following descriptors of reproductive output: clutch size and mass, relative clutch mass (RCM), average egg mass and offspring size. We found a positive relationship between maternal size and clutch size and mass, but no relationship between maternal size and RCM, average egg mass or hatchling size, demonstrating that the relative reproductive output is not influenced by female size, and that the only way to increase reproductive output is for the female to attain a greater body size. There exists an overall strong relationship between maternal body size and fecundity, thereby providing a potential explanation as to why female size is under selection in this species.
The time-course of ion and water transport across decapitated sunflowers for 32 h after detopping

Sunflowers growing in water culture solution containing only six ions (K+, Na+, Ca2+, Mg2+, Cl−, and NO3−) were decapitated and the exudate was allowed to accumulate in vinyl tubes. Measurements of biopotential, exudation rate, and ion concentration in the exudate and the nutrient medium were made at 4-h intervals during the 32-h period after detopping. The exudation rate, fluxes for each ion, biopotentials, and Δ E values for each ion were plotted on a time axis. With the fluxratio equation, chloride, nitrate, and potassium were observed to be entering actively, whereas for the other cations the gradient inward was passive. The active or passive movement for each ion and the diurnal cycles in exudation and ion fluxes changed as time after detopping increased. These changes might be accounted for in terms of the effects of detopping which remove the supply of energy compounds necessary for the normal functioning of the root.
Resource use and coexistence of two syntopic hylid frogs (Anura, Hylidae)

Os objetivos deste trabalho foram medir e comparar a amplitude e a sobreposicao de nicho de Hyla nana e Hyla sanborni em tres pocas vizinhas. As dimensoes de nicho medidas foram a ocorrencia sazonal, o sitio de vocalizacao e a dieta, alem da sobreposicao multidimensional. Machos de H. nana sao maiores que os de H. sanborni. A ocorrencia sazonal de H. sanborni foi maior nos corpos d'agua permanentes, enquanto H. nana apresentou maior periodo de ocorrencia no corpo d'agua temporario. O sitio de vocalizacao foi similar para ambas as especies; no entanto, H. sanborni ocupou poleiros mais altos do que H. nana. Diptera (Nematocera) foi o item mais consumido por ambas as especies nos tres corpos d'agua, mas, em geral, H. nana consumiu presas maiores que H. sanborni. O consumo de presas foi relacionado a sua disponibilidade no ambiente para ambas as especies. A sobreposicao multidimensional entre H. nana e H. sanborni foi mais alta nos corpos d'agua permanentes do que no corpo d'agua temporario, onde H. sanborni foi rara. Estas especies ocorreram em abundâncias diferentes nos tres corpos d'agua, consumiram presas de tamanhos diferentes e provavelmente possuem diferenca no periodo de alimentacao. Alem disso, os dados obtidos sugerem que diferencas estruturais nos corpos d'agua podem modificar a dinâmica de partilha de recursos entre estas especies. Apesar da grande sobreposicao encontrada nos sitios de vocalizacao e categoria de presas ingeridas, diferencas detectadas em outras dimensoes (ocorrencia sazonal e volume de presas consumidas) podem ser suficientes para permitir a coexistencia destas especies.