Miracle-dz/UniFAR-FTUs huggingface dataset:
Functionof Obliterative Bronchiolitis: Regulation and CXCR3 and Its Ligands in a Murine Model

Lung transplantation remains the only effective therapy for patients with end-stage lung disease, but survival is limited by the development of obliterative bronchiolitis (OB). The chemokine receptor CXCR3 and two of its ligands, CXCL9 and CXCL10, have been identiﬁed as important mediators of OB. However, the relative contribution of CXCL9 and CXCL10 to the development of OB and the mechanism of regulation of these chemokines has not been well deﬁned. In this study, we demonstrate that CXCL9 and CXCL10 are up-regulated in unique patterns following tracheal transplantation in mice. In these experiments, CXCL9 expression peaked 7 days posttransplant, while CXCL10 expression peaked at 1 day and then again 7 days posttransplant. Expression of CXCL10 was also up-regulated in a novel murine model of lung ischemia, and in bronchoalveolar lavage ﬂuid taken from human lungs 24 h after lung transplantation. In further analysis, we found that 3 h after transplantation CXCL10 is donor tissue derived and not dependent on IFN- (cid:1) or STAT1, while 24 h after transplantation CXCL10 is from recipient tissue and regulated by IFN- (cid:1) and STAT1. Expression of both CXCL9 and CXCL10 7 days posttransplant is regulated by IFN- (cid:1) and STAT1. Finally, we demonstrate that deletion of CXCR3 in recipients reduces airway obliteration. However, deletion of either CXCL9 or CXCL10 did not affect airway obliteration. These data show that in this murine model of obliterative bronchiolitis, these chemokines are differentially regulated following transplantation, and that
IN VIVO AND IN VITRO

ifir in both rachitic and control animals, sug gesting that the Â°9U'Tclabel conferred specificity and favored the rachitic lesions. Employing the rat tibia in an in vitro system, 9omTcO4 uptake was predominantly in the organic bone matrix; radioactive calcium, 32P-pyrophosphate, or â€œC diphosphonate uptake was mainly in the bone mineral ; and osmTc@pyrophosphate, stmTc@di. phosphonate, and o9mTc@polyphosphate were found in both mineraland organicphases.By removal of both mineral and polysaccharide and by using agents that altered the degree of col lagen fibril cross-linking, evidence was obtained suggesting that s9mT@/J and 9smTc@pyrophos. phate are preferentially bound by immature collagen.
An Investigation into Consumer Switching Behavior from the Online to the Offline Channel

Despite an impressive growth of online sales, the bricks-and-mortar bandwagon still remain high-profile in the realm of consumer channel switching behavior. Different from the existing research exploring the consumer switching behavior from the offline to the online retailer, this study is an effort to investigate why and when do consumers switch from the online to the offline channel by applying the push-pull-mooring framework. Thus, structural equation modeling and SPSS were used to test the established hypotheses. The results, as expected, show that both push factors (i.e., perceived risk and dissatisfaction) and pull factors (alternative attractiveness and perceived ownership) are positively related to a consumer’s intention to switch from the online to the offline channel. Moreover, all of expected interactions between push factors and mooring factors (i.e., switching costs, variety seeking, and subjective norms), and between pull factors and mooring factors are supported, except for the interactions between push factors and switching costs as well as between pull factors and subjective norms. Finally, implications and limitations are discussed.
Leveraging Normative Feedback to Promote Commitment-making and Long-term Water Conservation

Applied social psychology can aid the increasing need to improve water demand management interventions by developing strategies that target impactful behaviors and populations. This study aimed to encourage commitment-making and long-term water reductions using the binding commitment paradigm. Households received normative feedback regarding their water use, followed by feedback regarding their subsequent use of water (i.e., decrease or increase). Thereafter, households were asked to commit to water efficient practices. It was expected that those who reduced their water use after receiving normative feedback would be more likely to make a commitment than those who increased, as well as households who were asked to make a commitment after only receiving water restriction information. Additionally, it was predicted that those who reduced water use and made a commitment would reduce water use immediately after the commitment intervention and in a longer-term follow-up. Finally, it was expected that initially high-using households would be more likely to make a commitment in the normative feedback + commitment condition than the information + commitment condition. Results indicated significant main effects for treatment; households in all normative feedback conditions, as well as the information + commitment group reduced overall water use. Planned comparisons revealed that no treatment group maintained water reductions. The commitment-making rate did not differ between those who increased or decreased usage or between commitment conditions, and baseline water use did not moderate the relationship between commitment condition and commitment-making. The results did not support any of the hypotheses, suggesting that normative feedback does not promote commitment-making.
ITERATIVE REWEIGHTED ALGORITHM FOR NON-CONVEX POISSONIAN IMAGE RESTORATION MODEL

An image restoration problem with Poisson noise arises in many applications of medical imaging, astronomy, and microscopy. To overcome ill-posedness, Total Variation (TV) model is commonly used owing to edge preserving property. Since staircase artifacts are observed in restored smooth regions, higher-order TV regularization is introduced. However, sharpness of edges in the image is also attenuated. To compromise beneﬁts of TV and higher-order TV, the weighted sum of the non-convex TV and non-convex higher order TV is used as a regularizer in the proposed variational model. The proposed model is non-convex and non-smooth, and so it is very challenging to solve the model. We propose an iterative reweighted algorithm with the proximal linearized alternating direction method of multipliers to solve the proposed model and study convergence properties of the algorithm.
Lymphocytic Leukemia B Cells Switch DNA Recombination in Chronic Ongoing In Vivo Immunoglobulin Class

Chronic lymphocytic leukemia (CLL) results from the expansion of malignant CD5 (cid:1) B cells that usually express IgD and IgM. These leukemic cells can give rise in vivo to clonally related IgG (cid:1) or IgA (cid:1) elements. The requirements and modalities of this process remain elusive. Here we show that leukemic B cells from 14 of 20 CLLs contain the hallmarks of ongoing Ig class switch DNA recombination (CSR), including extrachromosomal switch circular DNAs and circle transcripts generated by direct S (cid:2) 3 S (cid:3) , S (cid:2) 3 S (cid:4) , and S (cid:2) 3 S (cid:5) as well as sequential S (cid:3) 3 S (cid:4) and S (cid:3) 3 S (cid:5) CSR. Similar CLL B cells express transcripts for activation-induced cytidine deaminase, a critical component of the CSR machinery, and contain germline I H -C H and mature V H DJ H -C H transcripts encoded by multiple C (cid:3) , C (cid:4) , and C (cid:5) genes. Ongoing CSR occurs in only a fraction of the CLL clone, as only small proportions of CD5 (cid:1) CD19 (cid:1) cells express surface IgG or IgA and lack IgM and IgD. In vivo class-switching CLL B cells down-regulate switch circles and circle transcripts in vitro unless exposed to exogenous CD40 ligand and IL-4. In addition, CLL B cells that do not class switch in vivo activate the CSR machinery and secrete IgG, IgA, or IgE upon in vitro exposure to CD40 ligand and IL-4. These ﬁndings indicate that in CLL
Prevention of common mental disorders among women in the perinatal period: a critical mixed-methods review and meta-analysis

Abstract Perinatal depression and anxiety account for a high burden of perinatal morbidity and poor psychosocial functioning. There is a growing interest among mental health professionals, to devise interventions to prevent this condition. This review synthesizes evidence for the effectiveness of psychological and psychosocial interventions aimed at the prevention of perinatal depression and anxiety. We also explore qualitative evidence to understand the acceptability and feasibility of these interventions. Using a mixed-methods approach, data from a total of 21 studies were collated to inform the evidence for preventive interventions for perinatal depression and anxiety. Based on their theoretical orientations, these interventions were described by authors as cognitive-behavioral (n = 7); psychoeducational (n = 6); mindfulness (n = 2); and interpersonal psychotherapy (n = 2). These also included psychosocial approaches such as social support (n = 1) and multicomponent interventions (n = 3). For depressive symptoms, these interventions yielded moderate to strong effect sizes in favor of the intervention group [standardized mean difference (SMD) = −0.59; 95% confidence interval (CI) −0.95 to −0.23]. For anxiety symptoms, a strong effect size was estimated in favor of the intervention group (SMD = −1.43, 95% CI −2.22 to −0.65). Preventive interventions significantly reduce the severity of perinatal depressive and anxiety symptoms. These interventions are also acceptable and feasible in many settings.
The Role of Islamic Corporate Governance in Preventing Fraud

: This research aims to examine the Sharia banks’ health, registered at Bank Indonesia, towards fraud through the role of Islamic Corporate Governance. The independent variables were Non-Performance Financing (NPF), Operational Efficiency Ratio (BOPO), and Capital Adequacy Ratio (CAR), with Islamic Corporate Governance (ICG) as a moderating variable. The dependent variable in this research was fraud. The population in this research were all Sharia Banks registered at Bank Indonesia year 2015 to 2018. The sample was selected using purposive sampling method. The total sample used in this study were 60 Sharia Banks. The analytical method of this research used moderation regression analysis. The results showed that, NPF has a significant negative influence toward fraud, CAR has a significant positive influence toward fraud, while BOPO has no influence toward fraud. Islamic Corporate Governance (ICG) played a role in strengthening the influence of NPF and CAR toward fraud. However ICG was unable to strengthen the influence of BOPO toward fraud in Sharia Banks registered at Bank Indonesia.
Analyzing Factors Affecting Loyalty and Decisions to Open an Online Store of Indonesian Sellers through Marketplace (Case Study of Fashion Product Sellers in E-Commerce Lazada Indonesia)

: Business actors can now market their items on a variety of channels thanks to technological advancements. Lazada is one of them. The software provides a platform for sellers to connect with their ideal clients. In 2018, Lazada is expected to face a drop. In truth, the e-commerce industry has always grown, particularly since the COVID-19 pandemic. Lazada is a well-known e-commerce company that frequently competes with other major players such as Shopee, Tokopedia, and others. Despite fierce competition, Lazada has managed to stay afloat thus far by focusing on transaction prices and delivery services. Through this, the goal of this study was to see how transaction prices and delivery service affected customer loyalty and sales decisions. A survey is utilized as a quantitative method. Structural equation modeling is the data analysis technique that was used. The findings reveal that transaction prices and service quality have a favorable and considerable impact on customer loyalty and decision to open.Transaction costs and delivery service will be the main factors that are considered by sellers before deciding to open a store at Lazada and give their commitment to be loyal.
DevelopmentTyrosine Phosphorylation during Thymic Tyrosine Phosphatase in Regulating Lck Changes in the Role of the CD45 Protein

† CD45-dependent dephosphorylation of the negative regulatory C-terminal tyrosine of the Src family kinase Lck, promotes efﬁcient TCR signal transduction. However, despite the role of CD45 in positively regulating Lck activity, the distinct phenotypes of CD45 and Lck/Fyn-deﬁcient mice suggest that the role of CD45 in promoting Lck activity may be differentially regulated during thymocyte development. In this study, we have found that the C-terminal tyrosine of Lck (Y505) is markedly hyperphosphorylated in total thymocytes from CD45-deﬁcient mice compared with control animals. In contrast, regulation of the Lck Y505 phosphorylation in puriﬁed, double-negative thymocytes is relatively unaffected in CD45-deﬁcient cells. These changes in the role of CD45 in regulating Lck phosphorylation during thymocyte development correlate with changes in coreceptor expression and the presence of coreceptor-associated Lck. Biochemical analysis of coreceptor-asso-ciated and nonassociated Lck in thymocytes, and in cell lines varying in CD4 and CD45 expression, indicate that CD45-dependent regulation of Lck Y505 phosphorylation is most evident within the fraction of Lck that is coreceptor associated. In contrast, Lck Y505 phosphorylation that is not coreceptor associated is less affected by the absence of CD45. These data deﬁne distinct pools of Lck that are differentially regulated by CD45 during T cell development. The Journal of Immunology, 2007, 178: 2056–2064. cells, whereas pre-TCR signaling and the development of dou-ble-positive (DP) T cells is less severely affected This con-trasts with studies in Lck or Lck/Fyn-deﬁcient mice, where there is a more severe defect in pre-TCR signaling resulting in a failure to transition from the double-negative (DN) to DP stage of thymic development The different phenotypes of Lck and CD45-deﬁcient mice suggest that the role of CD45 in regulating Lck activation may be developmentally regulated during thymocyte development. In this study, we have found that regulation of C-terminal tyrosine phosphorylation of coreceptor-associated Lck in DP cells is CD45-dependent. In contrast, regulation of Lck Y505 phosphorylation in DN thymocytes, as well as nonraft, non-coreceptor-associated Lck, is relatively independent of CD45 expression. In total, these data deﬁne distinct pools of Lck that are differentially regulated by CD45 and coreceptors during thymic development.
Supplementary of “SCARLET-NAS: Bridging the Gap between Stability and Scalability in Weight-sharing Neural Architecture Search”

Proof. First, we prove that Equation 3 (main text) holds for ∀o ∈ {0, 1, . , n − 2}. In this case, it’s sufficient to prove the output of the first convolution Conv(cl,m,k,k) can be exactly matched by adding Conv(cl,cl+1,1,1) before Conv(cl+1,m,k,k). Let W 1 cl,cl+1,1,1 and W 2 cl,m,k,k be the weight tensors of Conv(cl,cl+1,1,1) and Conv(cl+1,m,k,1) respectively. Let W 3 cl,m,k,k be the weight tensors of Conv(cl,m,k,1). Let w be one element of the tensor. We have
On the formal justification of informal proofs

: When modeling the informal proofs of Euclid’s Elements using the sound logical system E , we go from proofs seen as somewhat nonrigorous – even having gaps to be filled – to rigorous proofs. According to the ‘standard view’, the correctness of an informal proof is underwritten by the existence of a corresponding formal derivation. However, metalogic grounds the soundness of the logical system E , and proofs in metalogic are not like formal proofs and look suspiciously like informal proofs. In our view, they are informal proofs. This brings about what we are calling here the groundedness problem: how can we show with certainty that our metalogical proofs are correct and sustain our logical system? According to the ‘standard view’, we cannot. In this way, we would have to doubt the soundness of the formal system E . This in turn might lead us to doubt the justification of Euclidean informal proofs in terms of the corresponding formal proofs in E .
Mobile assisted language learning:

Mobile assisted language learning (MALL) research has been characterized by an overemphasis on technology, while the wide variety of approaches to the uses of mobiles has painted an atomized picture of L2 instruction. This paper discusses various conceptualizations of MALL that favour areas of language learning that are anchored on different theories of learning and language learning. Drawing on the seminal work by Traxler (2018, 2019), as well as on research that has examined self-directed uses, the use of apps and Augmented Reality (AR) in MALL, the authors contend that it is essential to shift our focus away from device-oriented pedagogies to more socially situated practices that take stock of new ecologies of language use. We contend that the research field is in search of a wider theoretical perspective in the context of SLA and language education that explores what we label here as socially contextualized MALL.
Self-esteem in Spanish secondary school students: dimensions and influence of personal and educational variables

Interest in self-esteem during adolescence is essential, because promoting positive self-es-teem and reducing the impact of negative self-esteem enables the optimal development of many school and personal experiences and general well-being. This study aimed to evaluate the validity and reliability evidence of the Rosenberg Self-Esteem Scale in Spanish students and to determine whether gender, age, academic course and type of school are decisive for its development. A total of 698 Compulsory Secondary Education (CSE) students participated, grouped into two random samples (Sample 1: 364 students, M = 12.57, SD = .49, and Sample 2: 334 students, M = 14.62, SD = .48). The results identified a two-factor structure (positive self-esteem and negative self-esteem) (χ 2 /df = 2.938, CFI = .948, NNFI = .924, SRMR = .045, RMSEA = .075), with high internal consistency (α = .853). Multivariate analysis showed that adolescents have higher positive self-esteem if they are male, are in first, second, or third grade CSE, and study in concerted schools, whereas male adolescents who study first grade CSE at ages under 13 present high negative self-esteem. The Rosenberg scale has been shown to have adequate psychometric properties to be used in secondary school students in Spain.
Assessment of the quality of natural childbirth care in hospital setting through the Bologna index

: Objective: To assess the quality of care during natural childbirth in hospital setting through the Bologna Index. Method : This is an observational and cross-sectional study, with a quantitative design, performed in a reference service in obstetric care, located in the Northeast region/Brazil. A form based on the quality indicators of the Bologna Index and guidelines for natural childbirth and puerperal care was used. Data were analyzed through descriptive and inferential statistics. When analyzing the Bologna Index, 1 point was assigned to each variable met; and, after assessing each item, care was classified based on the following sum: “0” for lower quality, “1 to 4” for intermediate quality and “5” for higher quality of care. Results: It was found an average of 3.44 in the Bologna Index, corresponding to intermediate quality care. Among the five variables that make up the Bologna Index, the highest percentages were related to the use of partograph (85.4%), presence of a caregiver at the time of
REGULARITY OF THE GENERALIZED POISSON OPERATOR

Let L = − ∆ + V be a Schr¨odinger operator, where the potential V belongs to the reverse H¨older class. In this paper, by the sub- ordinative formula, we investigate the generalized Poisson operator P Lt,σ , 0 < σ < 1, associated with L . We estimate the gradient and the time- fractional derivatives of the kernel of P Lt,σ , respectively. As an application, we establish a Carleson measure characterization of the Campanato type space C γL ( R n ) via P Lt,σ .
Delivery Efficiency of Technetium-99m DTPA Aerosol TO THE EDITOR: Lung ventilation imaging employing radioaerosols of technetium-99m diethylenetriaminepentaa

TO THE EDITOR: Lung ventilation imaging employing radioaerosols of technetium-99m diethylenetriaminepentaa cetic acid ([99mTCJDTPA)h@ now become established as an alternative to radiogases in the differential diagnosis of pul monaryemboli.However,all the commercialaerosolsystems have low efficiency when the activity retained in the patient's lung is expressed as a percentage of the activity nebulized. As we have been long-time advocates of the use of radioaerosols we were very interested to read the report by Sirr et al. (1) on the increased efficiency obtained by using a solution of 10% ethanol in saline with the [@mTc]DTPA.We hoped that this might enable us to reduced the activity required for nebuli zation. Unfortunatelywe have been unable to document any significant increase in the average delivery efficiency to our patients. The delivery efficiency was measured in I4 consecutive patients in whom the [99mTc]DTPAwas prepared using 10% ethanol and compared to a previous study in 22 patients with the same nebulizer systemâ€• in whom saline alone was used. The activity retained in the lungs from the aerosol was calcu lated by noting the count rate from the posterior view and comparing this to the count rate from the perfusion image for the same patient for whom the perfusion activity was accu rately known. The delivery efficiency in the 22 patients using saline alone ranged from 1.6% to 15.7% with a mean of 7.6%. In the 14 patients in whom 10% ethanol in saline was used, the range of delivery efficiency was 2.4% to 15.2% with a meanof7.8%. Sirr et al. (1) employed a different aerosol systemt although this is unlikely to be the cause ofthe discrepancy in the results. They presented quantitative data in only 2 normal subjects although they state that several hundred patients have been imaged. It is our experience that a much wider variation in delivery efficiency is found in patients than in controls due to greater variation in depth and rate of breathing. Although small increases in efficiency may be achieved in some patients by using 10% ethanol, the average efficiency remains un changed, thereby negating our efforts to reduce the activity.
Field evaluation of some insecticides against white grub, Lepidiota mansueta B. (Coleoptera: Scarabaeidae), on potato (Solanum tuberosum) in Assam (India)

Field studies were conducted to evaluate the efficacy of six insecticides against white grub, Lepidiota mansueta, in potato in 2012 and 2013 at Majuli river island in Assam (India). All the insecticide treatments significantly reduced tuber damage as against untreated control. Of the insecticides tested, fipronil 5 SC @ 150 g a.i.ha−1 showed low tuber damage on weight basis (5.24 and 4.57%) and was at par with fipronil 5 SC @ 100 g a.i.ha−1 (5.91 and 5.09%), chlorpyriphos 20 EC @ 400 g a.i. ha−1 (5.55 and 6.2%) and quinalphos 25 EC @ 400 g a.i.ha−1 (6.14 and 6.72%). On number basis, fipronil 5 SC @ 150 g a.i.ha−1 showed lowest tuber damage (4.2%), followed by chlorpyriphos 20 EC @ 400 g a.i.ha−1 (5.25%) and quinalphos 25 EC @ 400 g a.i.ha−1 (5.66%). All insecticide treatments were at par in tuber yield, except emamectin benzoate 5% SG @ 12.5 g a.i.ha−1. Highest cost benefit ratio was observed in chlorpyriphos 20 EC @ 400 g a.i.ha−1 treatment (2.50 and 2.62), followed by quinalphos 25 EC @ 400 g a.i.ha−1 (2.23 and 1.85). Chlorpyriphos 20 EC @ 400 g a.i.ha−1 and quinalphos 25 EC @ 400 g a.i.ha−1 seem better alternatives than fipronil to reduce infestation of L. mansueta in potato.