Miracle-dz/UniFAR-FTUs huggingface dataset:
Cored in the act: the use of models to understand core myopathies

ABSTRACT The core myopathies are a group of congenital myopathies with variable clinical expression – ranging from early-onset skeletal-muscle weakness to later-onset disease of variable severity – that are identified by characteristic ‘core-like’ lesions in myofibers and the presence of hypothonia and slowly or rather non-progressive muscle weakness. The genetic causes are diverse; central core disease is most often caused by mutations in ryanodine receptor 1 (RYR1), whereas multi-minicore disease is linked to pathogenic variants of several genes, including selenoprotein N (SELENON), RYR1 and titin (TTN). Understanding the mechanisms that drive core development and muscle weakness remains challenging due to the diversity of the excitation-contraction coupling (ECC) proteins involved and the differential effects of mutations across proteins. Because of this, the use of representative models expressing a mature ECC apparatus is crucial. Animal models have facilitated the identification of disease progression mechanisms for some mutations and have provided evidence to help explain genotype-phenotype correlations. However, many unanswered questions remain about the common and divergent pathological mechanisms that drive disease progression, and these mechanisms need to be understood in order to identify therapeutic targets. Several new transgenic animals have been described recently, expanding the spectrum of core myopathy models, including mice with patient-specific mutations. Furthermore, recent developments in 3D tissue engineering are expected to enable the study of core myopathy disease progression and the effects of potential therapeutic interventions in the context of human cells. In this Review, we summarize the current landscape of core myopathy models, and assess the hurdles and opportunities of future modeling strategies. Summary: The core myopathies are neuromuscular disorders with no cure. In this Review, we outline our current understanding of pathomechanisms, the advantages and limitations of available models, and discuss emerging modeling technologies.
机器人辅助与电视辅助胸腔镜肺段切除术治疗早期非小细胞肺癌短期效果比较

背景与目的 肺段切除术的开展越来越广泛，在现在的外科技术下，电视辅助胸腔镜手术（video-assisted thoracic surgery, VATS）是广泛采用的手术方式，同时机器人辅助胸腔镜手术（robot-assisted thoracic surgery, RATS）也提供了一种精准高效的手术方式，本研究旨在对比两种手术方式在肺段切除术中的短期效果。 方法 回顾性分析2016年1月-2017年4月在青岛大学附属医院胸外科行VATS及RATS肺段切除术的患者临床资料，比较两组患者基线数据及手术时间、术中失血量、淋巴结切除数、术后胸腔引流管带管天数、术后住院天数、术后房颤及肺部感染发生率等。 结果 共166例患者接受肺段切除术，两组均无中转开胸及围手术期死亡病例。 其中VATS 85例，RATS 81例，术中淋巴结切除数在RATS组多于VATS组，差异具有统计学意义[（13.07±5.08）个vs（10.81±5.74）个，P=0.010）]，两组在手术时间、术中失血量、术后带管时间及住院时间无统计学差异（P > 0.05），术后的房颤、肺漏气（≥6 d）及术后肺炎发生率方面二组差异无统计学意义（P > 0.05）。 结论 相比于VATS，RATS具有相似的安全性及可操作性，淋巴结切除数目较VATS明显为多。
Exploring the Association Between Work–Family Conflict and Job Involvement

Past research among U.S. correctional staff has found that work–family conflict has negative outcomes such as decreasing job satisfaction, decreasing organizational commitment, and increasing job stress. Little empirical research has addressed the association of the specific types of work–family conflict with job involvement. The present study contributes to the literature by separately analyzing the relationship of the four specific major types of work–family conflict (time-based conflict, strain-based conflict, behavior-based conflict, and family-on-work conflict) with job involvement among surveyed staff at two Chinese prisons. Job involvement varied by the type of work–family conflict. Specifically, time-based conflict and strain-based conflict had nonsignificant association with job involvement, but behavior-based and family-based conflicts had significant negative associations.
A Graph Neural Network Assisted Monte Carlo Tree Search Approach to Traveling Salesman Problem

We tackle the classical traveling salesman problem (TSP) by combining a graph neural network and Monte Carlo Tree Search. We adopt a greedy algorithm framework to derive a promising tour by adding the vertices successively. A graph neural network is trained to capture graph motifs and interactions between vertices, and then to give the prior probability of selecting a vertex at every step. Instead of making decisions directly based on the output of graph neural networks, we combine the graph neural network with Monte Carlo Tree Search to provide a more reliable policy as the output of the latter is the feedback information by fusing the prior probability with the scouting exploration. Without much heuristic designing, our approach outperforms recent state-of-the-art learning-based methods on the TSP. Experimental results demonstrate that the proposed method can be generalized to instances with more vertices than those used during the training.
The Effect of an Assertiveness Training Program on Schizophrenic Patients

Chronic schizophrenic patients tend to be excessively compliant, submissive, and socially inhibited. Moreover, deficits in assertiveness skills are important components of social dysfunction in schizophrenia. Aim of the study: Aim of this study was to assess the effect of an assertiveness training program on assertiveness skills and self esteem of schizophrenic patients. Design: A quasi experimental design was used in this study. Setting This study was conducted at the Psychiatric Mental Health Hospital in Benha City, Kaluobia Governorate. Subjects: A convenience sample of chronic schizophrenic patients, study subjects included 60 male patients were recruited for the study, divided into equally two groups (control and study groups). The study group only was received the assertiveness training program. Tools for data collection: The study tools divided into three tools. Tool (1): Structured Interview Questionnaire to assess socio-demographic and clinical characteristics, tool (II): Assertiveness Scale, and tool (III): Self Esteem Scale. Results: The results indicated that the mean scores of assertiveness skills of the study group was improvement at post program implementation (21.16±1.80) comparing to pre program (10.40±3.83), and the results indicated that the mean scores of self esteem of the study group was improvement at post program implementation (19.86± 5.28) comparing to pre program (36.96±5.23), and was found a highly statistically significant negative correlation between self esteem and assertiveness level of the studied sample. Conclusion: The assertiveness training program had positive effect on assertiveness skills and self esteem of the schizophrenic patients after receiving assertiveness training program. Recommendation: Based on the results of this study we recommended, continuous follow-up for schizophrenic patients participating in assertiveness training program to support and boost their learning skills. Further studies, using a larger probability sample and female patients for generalization of the results.
The Relationship Between Customers’ Tendency to Risk Avoidance and Preferring Online Banking Services1

The purpose of this study is to reveal that the relationship between the risk avoidance and the use of the Internet banking. For this reason, data collected by convenience sampling from 394 the Internet banking customers. Data was analyzed by Structural Equation Model in Smart PLS 2.0 program. The main findings of the study are: When the content of the Internet banking sites of banks improves and ease of use of the Internet banking increases, risk aversion is reduced. Besides, when risk avoidance decreases, trust, duration and frequency of the Internet banking increases. Results of this study have some implications for academic, banks managers and other policy makers.
Monetary Policy, R&D and Economic Growth in an Open Economy

This study analyzes the growth and welfare effects of monetary policy in a twocountry Schumpeterian growth model with cash-in-advance constraints on consumption and R&D investment. We find that an increase in the domestic nominal interest rate decreases domestic R&D investment and the growth rate of domestic technology. Given that economic growth in a country depends on both domestic and foreign technologies, an increase in the foreign nominal interest rate also decreases economic growth in the domestic economy. When each government conducts its monetary policy unilaterally to maximize the welfare of only domestic households, the Nash-equilibrium nominal interest rates are generally higher than the optimal nominal interest rates chosen by cooperative governments who maximize the welfare of both domestic and foreign households. This difference is caused by a cross-country spillover effect of monetary policy arising from trade in intermediate goods. Under the CIA constraint on consumption (R&D investment), a larger market power of firms decreases (increases) the wedge between the Nash-equilibrium and optimal nominal interest rates. We also calibrate the two-country model to data in the Euro Area and the UK and find that the cross-country welfare effects of monetary policy are quantitatively significant. JEL classification: O30, O40, E41, F43
Intervention Program for Nurses about Care of Preterm Neonates Undergoing Continuous Positive Airway Pressure

Continuous positive airway pressure (CPAP) is used when the preterm neonate is breathing spontaneously without a mechanical ventilator. Nursing care provided to preterm neonates undergoing CPAP is essential for improvement neonates' condition. The study aimed to improve nursing care provided to preterm neonates undergoing CPAP ventilation. This study was carried out at Neonatal Intensive Care Units of Specialized Pediatric Hospital at Benha city. Sample of the study was a convenient sample for nurses and purposive sample for preterm neonates who consisted of preterm neonates on CPAP and nurses who cared for them at previously mentioned settings. Tools of data collection included three tools, ( ) A structured Interviewing Questionnaire Sheet which composed of personal data of the nurses and Nurses, knowledge regarding nursing care for preterm neonates undergoing CPAP ventilation, ( ) Medical Record of Preterm Neonates undergoing CPAP Ventilation, and ( ) observational checklist for nursing care provided for preterm neonates undergoing CPAP ventilation. The main results of this study revealed that, there was highly statistical significant improvement in the studied nursesʹ total level of knowledge and total performance post program implementation. The main recommendation is conducting an orientation programs for nurses in NICU with regular updates of knowledge and practice regarding continuous positive airway pressure.
Personality of Musicians: Age, Gender, and Instrumental Group Differences

It is clear that much of musical behavior, in general, is mediated by individual characteristics in the domains of cognitive abilities, motivation and structure of personality. The idiosyncratic complex of these features represents a frame of reference through which experiences are processed and outcomes delivered. Its complexity gives a “personal mark” to the processes of perception, cognition and emotional arousal which take place during different musical activities, such as listening, performing, creating and learning music. Knowing more about musical and personal potentials and skills broadens the understanding of the processes of music perception and cognition, giving them the place and the time “in person”. The aim of this paper is to present a research on personality profiles of musicians by applying a newer personality paradigm and, therefore, giving fresh perspectives of the personality of musicians.This study presents a part of the results of a wider research project which is dealing with the structure of musicians’ personality, by using the new paradigm – the Big-Five personality model and inventory (Costa & McCrae, 1995). It creates a possibility to compare these results to the previously established ones based on the Cattel’s theoretical framework and used in the Kemp’s landmark study (Kemp, 1996).
Edilgen Yapıların Edinimi: Anlambilimsel Ve Edimbilimsel Yaklaşım

Bu makale, edilgen yapıların edinilmesi açısından alanyazının genel bir incelemesini sunmanın yanı sıra, edilgen yapıların temel zorluk nedenleri olduğu düşünülen anlambilimi ve edimbilimi göz önünde bulundurularak yeni bir teorik yaklaşım sunmaktadır. Alanyazında edilgen yapıların zor olup olmadığı ve eğer zor ise, bu zorluğun altında yatan nedenlerin ne olabileceği konusunda bir anlaşmazlık vardır. Alanyazında sunulan argümanlara dayanarak, sözdizimsel hipotez (Wexler 2004) ve artımlı işleme hipotezi (Trueswell ve Gleitman 2004) öne çıkmaktadır. Wexler'ın sözdizimsel hipotezi, çocukların tüm küçük eylem öbeklerini ve tümleyici öbeklerini güçlü fazlar olarak görmelerini savunur ve bunun sonucunda çocuklar edilgen yapıları dilbilgisi dışı olarak gördüklerini iddia eder ki bu da Wexler’a göre zorluğun kaynağıdır. Bununla birlikte, her iki durumda da (sözdizimsel hipotez veya artımlı işleme), bu yapıların frekansı büyük rol oynamaktadır. Bu çalışmada son olarak ise edilgen yapıların neden bazı dillerde edinilmesinin zor olduğunu açıklamak için anlambilimsel ve edimbilimsel bakış açıları temel alınarak kuramsal bir analiz sunulmaktadır çünkü alanyazındaki edilgen yapılar ile ilgili çalışmalar anlam bileşenini ihmal etmektedir. Bu çalışmada, edilgen yapıların edinilmesine yeni teorik bir bakış açısı sağlamak için içlemsel anlambilim modeli (Von Fintel ve Heim 2011) kullanılmıştır.
Shoulder resurfacing: is it really as good as total shoulder replacement?

Cementless shoulder resurfacing arthroplasty differs in many aspects from the nonconstrained stemmed shoulder prosthesis. The design concept is replacement only of the damaged joint-bearing surfaces and restoration of normal anatomy with minimal bone resection. Shoulder resurfacing has been developed over the last 25 years with good initial and long-term results. Usage has increased worldwide. The indications are the same as for traditional shoulder replacements in degenerative arthritis. Surface replacement can either be done as humeral surface arthroplasty or total shoulder replacement. The results of shoulder resurfacing are at least comparable with those for stemmed prostheses. However, using shoulder resurfacing reduces the risk of complications involving the humeral shaft. Revision or arthrodesis, if the need arises, can be undertaken easier because the bone stock has been preserved. The long-term follow-up has proven the good outcome and the longevity of the Copeland cementless resurfacing prosthesis that remains a procedure of choice for the treatment of advanced arthritis of the shoulder.
Effect of Educational Program for Health Promoting Lifestyle among Patients with Hypertension

Background: Hypertension is a common health problem among adults, affecting approximately I billion individuals worldwide. Adopting healthy lifestyle behaviors is a vital issue in managing hypertension, since declines in the levels of awareness of hypertension even lower levels of control. Aim of the study: to evaluate the effectiveness of educational program for health promoting lifestyle among patients with hypertension. Aquasi-experimental design was used to conduct the current study in medical, cardiac and neurological outpatient clinics, at Benha University Hospital during the period from beginning of September 2016 till beginning of September 2017. Subjects: A sample of convenience of 104 patients recruited according to the study formula based on the total number of patients who admitted to the study settings during 2015. Tools: Three tools were utilized for data collection, 1) Structured interviewing sheet, 2) Hypertension Knowledge Level Scale (HK-LS) and 3) Health Promoting Lifestyle Profile II. Results: Showed that mean score regarding hypertension knowledge and health promoting lifestyle behavior were significantly higher after than before program with a negative and highly significant association between knowledge and health promoting lifestyle behavior as well as level of systolic blood pressure. Conclusion: Hypertension educational program was effective in promoting knowledge, behavior regarding healthy lifestyle and controlling hypertension among patients with hypertension. Recommendation: Increasing awareness about hypertension and importance of adopting healthy lifestyle in order to control the disease through health education programs to hypertensive patients were needed.
Pharmacologic treatments for generalised anxiety disorder: a systematic review and network meta- analysis

Background: Generalised anxiety disorder (GAD) is a disease associated with significant dysfunction. Pharmacologic treatment is often the first choice for clinicians due to the cost and resource constraints of psychological alternatives, but there is a paucity of comparative information for the multiple available drug choices. Methods: A systematic review and network meta-analysis was performed based on randomised trials in GAD identified from MEDLINE, Web of Science, Cochrane Library, ClinicalTrials.gov, Chinese National Knowledge Infrastructure (CNKI), Wanfang, Drugs@FDA and commercial pharmaceutical registries. Placebo and active control trials were included. Primary outcomes were efficacy (mean difference [MD] in change in Hamilton Anxiety Scale Score) and acceptability (study discontinuations for any cause). We estimated summary mean treatment differences and odds ratios using network meta-analyses with random effects. This study is registered with PROSPERO, number CRD42018087106. Findings: This analysis is based on 89 trials, which included 25,441 patients randomly assigned to 22 different active drugs or placebo. Duloxetine (MD: -3·13; 95% credible interval [CrI]: -4·13, -2·13) pregabalin (MD: -2·79; 95% CrI: -3·69, -1·91), venlafaxine (MD: -2·69; 95% CrI: -3·50, -1·89) and escitalopram (MD: -2·45; 95% CrI: -3·27, -1·63) were more efficacious than placebo with relatively good acceptability. Mirtazapine, sertraline, fluoxetine, buspirone and agomelatine were also found to be efficacious and well tolerated but these findings were limited by small samples. Quetiapine (MD: -3·60; 95% CrI: -4·83, -2·39) had the largest impact on HAM-A but it was poorly tolerated (OR: 1·44; 95% CrI: 1·16, 1·80) when compared to placebo. Likewise, paroxetine and benzodiazepine were effective but also poorly tolerated when compared to placebo. Interpretation: To our knowledge this is the largest contemporary review of pharmacological agents for the treatment of GAD using network analysis. There are several effective treatment choices for GAD across classes of medication. The failure of initial pharmacologic therapy may not be a reason to abandon a pharmacologic treatment strategy. Funding: No funding was received for this research.
Use of shear wave elastography in the evaluation of liver fibrosis

Background and objective: Chronic liver disease promotes hepatic inflammation and fibrosis. When diagnosing and treating hepatic diseases such as chronic hepatitis C, it is important to evaluate the degree of liver fibrosis. We aimed to determine the diagnostic capabilities of shear wave elastography (SWE) in patients with liver disease. Materials and methods: Hepatic stiffness, size of liver and spleen, portal vein flow velocity, portal vein diameter and flow pattern of hepatic veins were evaluated in 24 patients with diagnosed liver disease and 15 healthy subjects. All measurements were performed using the Philips ElastPQ SWE. The hepatic stiffness was expressed in kilopascals (kPa). Results: The mean liver stiffness value was 4.18±1.15 kPa in the control group and 16.19±12.31 kPa inpatient group (p<0.001). An optimal SWE cut-off value of 5.51 kPa had predicted 88% sensitivity and 93% specificity for detecting liver fibrosis. The liver stiffness was positively correlated with the portal vein diameter and the flow pattern of hepatic veins (r=0.4, P<0.008), no significant correlation between liver stiffness and the size of the liver, spleen and portal vein flow velocity was found. Conclusions: The liver is stiffer in subjects with diagnosed liver disease than in those who are healthy. The sensitivity of the SWE is 88%, specificity 93% with a cut-off value of 5.51 kPa. Greater hepatic stiffness is associated with increased portal vein diameter, monophasic and biphasic flow patterns of hepatic veins.
Exploring Short Video Application Users’ Visit Intention: Applying the Stimulus-Organism-Response Model

This paper aims to extend the Stimulus-Organism-Response (S-O-R) model to social media context in China and validate the positive influence between short video, destination image, perceived interactivity, and short video application users’ visit intention. Data were collected through an online survey, a PLS-SEM analysis was used. The results (n=236) show that video quality significantly affects both the cognitive and affective image of the video destination, and the perceived interactivity significantly influences their behavioral intention. This study makes up for the deficiency of the theoretical research of social media and helps tourism departments to develop appropriate promotion strategies to destinations.
Title Wave-Breaking Turbulence in the Ocean Surface Layer Permalink

Observations of winds, waves, and turbulence at the ocean surface are compared with several analytic formulations and a numerical model for the input of turbulent kinetic energy by wave breaking and the subsequent dissipation. The observations are generally consistent with all of the formulations, although some differences are notable at winds greater than 15m s. The depth dependence of the turbulent dissipation rate beneath the waves is fit to a decay scale, which is sensitive to the choice of vertical reference frame. In the surface-following reference frame, the strongest turbulence is isolated within a shallow region of depths much less than one significant wave height. In a fixed reference frame, the strong turbulence penetrates to depths that are at least half of the significant wave height. This occurs because the turbulence of individual breakers persists longer than the dominant period of the waves and thus the strong surface turbulence is carried from crest to trough with the wave orbital motion.
Different contribution of carbon nanotubes and graphene oxide in single nucleotide polymorphism for the diagnosis of human mad-cow disease

Rapid single nucleotide polymorphism (SNP) with 1,1’oxalylimidazole chemiluminescence (ODI-CL) detection was developed for the early diagnosis of human mad-cow disease. Mutated single strand DNA (ssDNA) sequence discovered from patients having human mad-cow disease rapidly hybridize with complementary probe conjugated with chemiluminescent dye. The hybridization between target ssDNA and complementary probe was dependent on four different variables such as pH, temperature, incubation time, and the type of nanoparticles (e.g., multi-walled carbon nanotubes, graphene oxide) capable of capturing mismatched ssDNAs and excess complementary probe. However, three different types of mismatched ssDNAs also slowly hybridize with complementary probe with the increase of incubation time. The problem was solved by using ODI-CL detection instead of fluorescence detection of conventional SNP because ODI-CL is about 100 times more sensitive than fluorescence. In other words, it was possible to reduce the interaction between mismatched ssDNAs and complementary probe with short incubation time (15 minutes) using highly sensitive ODI-CL detection. Based on the results, in conclusion, it is expected that SNP with ODI-CL can be applied as a cost-effective, rapid, and simple analytical method to diagnose and prognose various diseases.