Miracle-dz/UniFAR-FTUs huggingface dataset:
Investigating the Association Between Fusobacterium nucleatum and Oral Squamous Cell Carcinoma: A Pilot Case-Control Study on Tissue Samples

Background Fusobacterium nucleatum (F. nucleatum) has been increasingly linked to oral squamous cell carcinoma (OSCC), prompting this study to explore its presence using polymerase chain reaction (PCR) and evaluate its clinical significance. Methods In this pilot case-control study, 12 OSCC tissue samples and 12 non-cancerous oral mucosal tissue samples were analyzed. Total RNA extraction and complementary DNA (cDNA) synthesis were performed using Trizol-based methods, followed by PCR amplification and gel electrophoresis. The clinical characteristics of participants and PCR results were recorded. Results Among the OSCC tissue samples, three out of 12 tested positive for F. nucleatum, while none of the control samples showed its presence. The detection rate of F. nucleatum in OSCC was 25%. Gel analysis confirmed specific amplicon amplification, and ImageJ software enabled copy number quantification. Discussion Our findings support previous research indicating a potential association between F. nucleatum and OSCC. Understanding the etiological significance of F. nucleatum in OSCC has clinical implications, including early detection, risk stratification, and prognostication. However, the limited sample size and the need for further research to elucidate underlying mechanisms are acknowledged. Conclusion This pilot study provides initial evidence of F. nucleatum’s presence in a subset of OSCC samples, supporting its potential association with oral cancer. Detecting F. nucleatum in OSCC tissues holds promise for future research and clinical applications as a diagnostic and prognostic biomarker. Understanding its role in oral carcinogenesis will facilitate the development of targeted therapeutic strategies. Larger studies are warranted to validate these findings and investigate the precise mechanisms involved.
Experimental and Theoretical Studies for the Behavior of Strip Footing on Oil-Contaminated Sand

This paper presents the results of a series of plain-strain model tests carried out on both clean sand and oil-contaminated sand loaded with a rigid strip footing. The objectives of this study are to determine the influence of oil-contaminated sand on the bearing capacity characteristics and the settlement of the footing. Contaminated sand layers were prepared by mixing the sand with an oil content of 0–5% with respect to dry soil to match the field conditions. The investigations are carried out by varying the depth and the length of the contaminated sand layer and the type of oil contamination. A plain-strain elastoplastic theoretical model with an interface gap element between footing and the soil is carried out to verify the test results of the model. It is shown that the load-settlement behavior and ultimate bearing capacity of the footing can be drastically reduced by oil contamination. The bearing capacity is decreased and the settlement of the footing is increased with increasing the depth and the .
The undrained strength - liquidity index relationship

A database of 641 fall cone tests on 101 soil samples from twelve countries has been analysed to determine the best mathematical relationship linking undrained shear strength with liquidity index. From the database, it is shown that the use of a linear relationship linking liquidity index and the logarithm of undrained shear strength that uses the commonly assumed 100-fold factor increase in strength from liquid to plastic limit over-predicts the measured data of soil strength. The use of a factor of about 35 for the ratio between the strength at liquid limit and that extrapolated to plastic limit is shown to be more realistic. Logarithmic liquidity index is examined and found to also correlate strongly with the logarithm of undrained shear strength, however it is shown that no great statistical improvement is present compared with the semilogarithmic formulation. When considering data of individual soils a power law fitting is shown statistically to be the preferred mathematical function.
Effects of reactive phosphate rock and superphosphate on sheep and pasture production in hill country

Arad reactive phosphate rock (RPR) and single superphosphate(SSP) werecomparedasphosphate fertilisers in a sheep farmlet grazing trial and in two mowing trials over 3 years. The trials were on a volcanic ash soil at the MAF Te Kuiti Research Area on a site with limited fertiliser addition in the previous 2 years (Olsen P soil test averaged 10 in the grazing trial). Soil sulphur levels were high and there was no requirement for added sqlphu_r over the -3 years of the trial. Pasture and animal measurements showed responses to SSP in all years, with RPR being initially less effective than SSP. By year 3, responses from RPR were near those from SSP. Economicassessmentof thegrazing trial corresponded with production data, except in year 1 when there was little benefit from either fertiliser. SSP was more cost-effective than RPR in year2 whereas they were similarin year 3. Over the 3 years, both fertilisers were profitable and there was an apparent cumulative net benefit from SSP over RPR. It was estimated that by year 4 the cumulative net benefit would be similar for both fertilisers or would be reversed in favour of RPR.
Construction of mid-crustal sheeted plutons: Examples from the North Cascades, Washington

Large parts of many orogenic belts consist of highly elongate plutons constructed by the injection of multiple sheets of magma. We describe in detail two such intrusions, the deep (∼20–25 km), mid-crustal Cardinal Peak and Entiat plutons, and emphasize the dynamic nature of these magma chambers. These ca. 72–73 Ma plutons consist of heterogeneous mafic complexes in their margins and tips that give way inward to thicker, but still abundant, sheets of tonalite. Intrusive and petrologic relationships provide evidence for injection of early mafic (mantle? ) and crustal melts, development of heated pathways utilized by larger batches of more felsic magma, and potentially a filtering mechanism in which conduits represented by the plutons fed larger, more homogenized magma bodies at shallower crustal levels. Well-developed, gently to moderately dipping magmatic and subsolidus foliations in these plutons are commonly discordant to sheet contacts, internal layering, and pluton contacts, but are continuous with host- rock foliation. They define small to map- scale magmatic folds, which have orientations and geometries similar to those of regional host-rock folds. These magmatic structures thus primarily record regional contractional tectonism during chamber construction. Host rocks also record complex processes during chamber evolution with narrow structural aureoles displaying remarkable lateral variability. Deflection of gently to moderately dipping host-rock markers toward parallelism with steep pluton contacts indicates vertical and largely downward ductile material transfer along sheet margins during emplacement. Several sharply discordant segments of pluton contacts imply late stoping. Regional ductile flow and folding also played a role, but regional faulting did not. Further evidence for chamber construction is provided by host- rock rafts, which are abundant along sheet contacts in the Cardinal Peak pluton and particularly between marginal sheets of the Entiat pluton, but are sparse elsewhere in the latter pluton. We interpret these relationships to indicate a temporal sequence in which magmatic sheets initially intruded host rock, then wedged aside this rock and coalesced, preserving pieces of the host along margins, and eventually formed large, relatively inclusion-free chambers as host rock was detached and transported vertically downward through the chamber.
EPIGEAL INSECT COMMUNITIES & NOVEL PEST MANAGEMENT STRATEGIES IN PACIFIC NORTHWEST HYBRID POPLAR PLANTATIONS

By Robert Andrew Rodstrom, Ph.D. Washington State University May 2013 Chair: John J. Brown Hybrid poplars are a short rotation woody crop grown for a variety of target markets including paper pulp, saw timber, and biofuels in the Pacific Northwest. Development of pest control strategies within hybrid poplar plantations over the last several decades has focused on controlling foliar feeding herbivores and wood boring pests, and has overlooked the epigeal arthropod community. Understanding this unstudied suite of organisms would allow pest managers to better evaluate the impact their management strategies have on the poplar agroecosystem. Qualitative surveys of the arthropod communities in hybrid poplar plantations and nearby native habitats demonstrated that a greater arthropod diversity persists in the surrounding native areas. Additionally, the poplar plantation’s epigeal arthropod community was composed of species found within sampled native areas.
Review of Phytochemical Potency as a Natural Anti-Helicobacter pylori and Neuroprotective Agent

Phytochemicals are plant secondary metabolites that show health benefits for humans due to their bioactivity. There is a huge variety of phytochemicals that have already been identified, and these compounds can act as antimicrobial and neuroprotection agents. Due to their anti-microbial activity and neuroprotection, several phytochemicals might have the potency to be used as natural therapeutic agents, especially for Helicobacter pylori infection and neurodegenerative disease, which have become a global health concern nowadays. According to previous research, there are some connections between H. pylori infection and neurodegenerative diseases, especially Alzheimer’s disease. Hence, this comprehensive review examines different kinds of phytochemicals from natural sources as potential therapeutic agents to reduce H. pylori infection and improve neurodegenerative disease. An additional large-scale study is needed to establish the connection between H. pylori infection and neurodegenerative disease and how phytochemicals could improve this condition.
Physicochemical Characterization of Dextran HE29 Produced by the Leuconostoc citreum HE29 Isolated from Traditional Fermented Pickle

In this study, lactic acid bacteria (LAB) strains were isolated from traditional fermented pickles, and among the identified strains, Leuconostoc citreum HE29 with a strong slimy colony profile was further selected to determine the physicochemical and techno-functional properties of its exopolysaccharide (EPS). Glucose was the only sugar monomer in the core unit of EPS HE29 detected by HPLC analysis, and glucan HE29 revealed 7.3 kDa of molecular weight. Structural characterization of glucan HE29 by 1H and 13C NMR spectroscopy analysis demonstrated that EPS HE29 was a dextran-type EPS containing 5.3% levels of (1 → 3)-linked α-D-glucose units. This structural configuration was also supported by FT-IR analysis, which also demonstrated the functional groups within the dextran HE29 structure. In terms of thermal properties detected by TGA and DSC analysis, dextran HE29 demonstrated a degradation temperature of around 280 °C, showing its strong thermal features. A semi-crystalline nature was observed for dextran HE29 detected by XRD analysis. Finally, AFM and SEM analysis revealed tangled network-like properties and web-like branched structures for dextran HE29, respectively. These findings suggest the importance of plant-based fermented products as LAB sources in obtaining novel EPS structures with potential techno-functional roles.
CLASSIFICATION OF WATER BODIES BASED ON BIOTIC AND ABIOTIC PARAMETERS AT THE VÁRZEAS OF MAMIRAUÁ RESERVE, CENTRAL AMAZON.

In order to describe and better understand the aquatic environment of the varzea lakes at Mamiraua Reserve throughout the Amazonian hydrologic cycle, a sample of 11 of those lakes were chosen mainly for their accessibility and diversity. They were visited every season, for 2 consecutive years and morphological, limnological and biodiversity data was recorded. The aquatic macrophytes and the invertebrates (specially molluscs, crustaceans, arachnids, and the insect orders) found in its root zone were the taxonomic groups aimed. All information was used to group and ordinate the samples, to generate broad categories of lakes for Mamiraua Reserve. All sampled lakes proved to present high similarity with others, with the exception of one, more similar with the closest main river. However, two distinct groups were identified, mainly due to differences in conductivity of the water, its temperature and the presence or relative abundance of particular groups of invertebrates. These groups were consistent with the morphology of the lakes, the types of banks and levees, the type of riparian forest and the geomorphologic origin of the lake. This conclusion is useful for the evaluation of significance levels of aquatic environment at protected zones for the management of the reserve, and for the design of further ecologic research on the aquatic environment at the area.
A Randomized Sparsity Preserving Projection and its Exponential Approach for Image Recognition

To preserve the sparse representation of the original high-dimensional data, sparsity preserving projection (SPP) is proposed which involves solving a series of <inline-formula> <tex-math notation="LaTeX">$\ell _{1}$ </tex-math></inline-formula> minimization problems and a large-scale generalized eigenvalue problem. Compared to many other dimensionality reduction techniques, SPP does not contain any model parameters. Besides, it may have some discriminative abilities even though no class labels are provided. However, SPP tends to show signs of fatigue when encountering with the large-scale high-dimensional data sets since the process of solving the <inline-formula> <tex-math notation="LaTeX">$\ell _{1}$ </tex-math></inline-formula> minimization problems is quite time-consuming. To manage this problem, this paper proposes a randomized SPP (RSPP) via random sketching where the <inline-formula> <tex-math notation="LaTeX">$\ell _{1}$ </tex-math></inline-formula> minimization problems can be solved efficiently. Furthermore, a preprocessed approach and an exponential approach with a bit of extra efforts are presented to handle the small-sample-size problem which may be occurred in RSPP. Finally, some experiments on image recognition for four authentic data sets are implemented and the corresponding results demonstrate the superiority of the proposed methods.
A pulmonary rehabilitation program reduces hospitalizations in chronic obstructive pulmonary disease patients: A cost-effectiveness study

BACKGROUND: Although pulmonary rehabilitation (PR) is recommended in patients with chronic obstructive pulmonary disease (COPD), there is a scarcity of data demonstrating the cost-effectiveness and effectiveness of PR in reducing exacerbations. METHODS: A quasi-experimental study in 200 patients with COPD was conducted to determine the number of exacerbations 1 year before and after their participation in a PR program. Quality of life was measured using the COPD assessment test and EuroQol-5D. The costs of the program and exacerbations were assessed the year before and after participation in the PR program. The incremental cost-effectiveness ratio (ICER) was estimated in terms of quality-adjusted life years (QALYs). RESULTS: The number of admissions, length of hospital stay, and admissions to the emergency department decreased after participation in the PR program by 48.2%, 46.6%, and 42.5%, respectively (P < 0.001 for all). Results on quality of life tests improved significantly (P < 0.001 for the two tests). The cost of PR per patient and the cost of pre-PR and post-PR exacerbations were €1867.7 and €7895.2 and €4201.9, respectively. The PR resulted in a cost saving of €1826 (total, €365,200) per patient/year, and the gain in QALYs was+0.107. ICER was −€17,056. The total cost was <€20,000/QALY in 78% of patients. Conclusions: PR contributes to reducing the number of exacerbations in patients with COPD, thereby slowing clinical deterioration. In addition, it is cost-effective in terms of QALYs.
Latitudinal gradients of solar wind speed around the ecliptic: Systematic displacement of the streamer belt

We study the effective latitudinal gradients of the solar wind (SW) speed in the two magnetic hemispheres around the heliographic equator by comparing observations at the Earth's orbit in Spring and Fall since 1964. We find that there is a large, statistically significant effective gradient of about 10 km/s/deg in the southern magnetic hemisphere around each solar minimum. However, no statistically significant effective gradient is found in the northern magnetic hemisphere. This difference implies a systematic displacement of the minimum speed locus of the streamer belt toward the northern magnetic hemisphere. We note that at least during one minimum the streamer belt and the heliospheric current sheet seem to have been oppositely displaced. We also show that the average SW speeds from the two magnetic hemispheres are roughly equal. Therefore, the earlier reported annual variation in SW speed at 1 AU is due to the displacement of the streamer belt and not due to different speeds from coronal holes of opposite polarity. The displacement of the streamer belt implies a new, persistent north‐south asymmetry related to the solar magnetic cycle which needs to be explained by realistic solar dynamo models.
Depositional Environment Characteristic of The Late Miocene Kerek Formation in Kendeng Basin: A Case from Cipluk Area, Kendal Regency, Central Java

This study focused on the Late Miocene Kerek Formation in Cipluk, Kendal Regency, Central Java, which belongs to the Kerek Formation, a lithostratigraphy unit characterized by Early Miocene - Late Miocene turbidite deposits. The research aims to comprehensively interpret the depositional environment characteristics of the Late Miocene Kerek Formation based on lithofacies, thin section analysis, and micropaleontological analysis. Gaining insights into facies characteristics and the depositional environment will offer novel perspectives for the exploration and development of oil and gas resources in the Kendeng basin. The methodology consists of data collection, analysis, and synthesis. Results indicate that the study area is dominated by classical turbidite facies, suggesting a distal zone with slow sediment settling. The analysis reveals that the Late Miocene Kerek Formation was deposited in a deep marine environment within the inner bathyal—outer bathyal bathymetry zone, specifically in the lower fan section of a submarine fan system. Based on the characteristics of existing deposits and facies, the deposition environment is identified as a fine-grained, mud-rich complex in an elongated submarine fan. These findings contribute to a better understanding of the Late Miocene depositional environment in the Kendeng Basin, Central Java.
Origin of Dolomite in the Eocene Castle Hayne Limestone, North Carolina

ABSTRACT A locally dolomitized 11.0-m section of the Castle Hayne Limestone is exposed in the Martin Marietta Aggregates Quarry in New Hanover County. A 1.0-m zone, 6.4 m below the overlying unconformity, consists entirely of sucrose-textured dolomite with intercrystalline and moldic porosity with vague outlines of the original allothems. The dolomite is nonstoichiometric (48 mole % MgCO3), nonferroan, and occurs as very fine to fine, anhedral to subhedral crystals, commonly with cloudy centers. The percentage of dolomite decreases fairly uniformly above and below this zone, and 3.6 m below the upper unconformity, the unit is undolomitized. Above and below the zone of maximum dolomitization, the dolomite selectively replaces the micrite matrix, and calcite allochems are unaffected. s dolomitization increases towards a maximum, calcite allochems are replaced. The lack of sabkha-type sedimentary structures, evaporite minerals, and the presence of a stenohaline marine-shelf fauna suggest hyposaline dolomitization consistent with the mixing-zone model. Analyses of the Na, Sr, and Cl content in acid-soluble material from a core drilled at this locality reveal that the Sr content systematically increases from 302 ppm at the top of the core to 524 ppm at the base. The Sr data suggest that the calcite and dolomite phases have been depleted in Sr, perhaps by hyposaline fluids. The strong positive correlation between Sr content and depth suggests a "memory" of a stratified (mixing-zone) fluid. Sodium ranges from a low of 252 ppm in calcite to a high of 1,500 ppm in dolomite, and a strong positive correlation exists between percentage of dolomite and Na concentration. The molar ratio of Na:Cl ranges from greater than 2:1 to 11:1; thus, the high Na values cannot be attributed to high salinity fluid inclusions in the dolomite. Although the high Na values associated with the dolomite suggest saline/hypersaline dolomitization, the acid-soluble Na was derived from a heulandite group zeolite which is present in the dolomites. The interlocking nature of the dolomite and zeolite crystals, the euhedral morphology of the zeolite and the strong correlation between percentage of dolomite to Na concentration suggest that both mineral phases are authigenic and formed penecontemporaneously. Unless the Na distribution can be documented, these data suggest that whole-rock Na concentrations in ancient dolomites may not be an accurate indicator for hyposaline versus hypersaline dolomitization. The laterally equivalent, undolomitized biomicrudite facies of the Castle Hayne Limestone has essentially no matrix porosity and little secondary moldic porosity. Thus, dolomitization has greatly enhanced the porosity and permeability of the biomicrudite facies in this area. Mixing-zone dolomitization caused by a lowering of eustatic sea level in conjunction with favorable hydrologic and geologic conditions can have a profound effect on reservoir properties and distribution.
Unraveling quench dynamics and real-time continuous detection in HTS tapes through distributed fiber optic sensing

High-temperature superconducting (HTS) tapes, coils, and magnets often experiences intricate quench instabilities and failures during high current-carrying operations, posing challenges to their practical applications. This study addresses the need for a measurement approach capable of monitoring multi-field signals in superconducting structures within cryogenic and extreme electromagnetic environments. We explore the application of distributed fiber optic sensing (DFOS) technology, specifically employing the optical frequency domain reflectometry scheme, which offers distinct advantages over traditional point-type electrical testing methods, particularly for superconducting materials and magnets. In this experimental study, we continuously track the quench evolution process in superconducting tapes using both bonded and stress-free fibers for real-time monitoring. A comprehensive analysis of the acquired temperature and thermoelastic strain profiles provides essential insights into the dynamic behavior of quench events. The findings demonstrate the effectiveness of DFOS in identifying and characterizing the onset and propagation of quenches. By arranging bonded and stress-free fibers in parallel on the HTS tape’s surface, we successfully decouple the effects of strain-temperature cross-sensitivity, enabling the extraction of temperature and train profiles. The bonded fiber optic sensor demonstrates rapid sensitivity to the thermally quenched events. Temporal derivatives of voltage and thermal strain exhibit characteristic plateaus and slope changes during quenches, respectively. The voltage rate displays two plateaus corresponding to superconducting-to-normal transitions, while strain rates exhibit potential as criteria for identifying quench events in HTS materials. Moreover, DFOS outperforms traditional terminal average voltage measurement, capturing quench evolution tails from the initial point of quench until the complete transition of the segment into the normal state. This experiment provides a solid foundation for further exploration of the underlying quench mechanism.