Miracle-dz/UniFAR-FTUs huggingface dataset:
membrane. PM6

Objectives: To examine erythrocyte membrane functions in mood disorder patients and to establish possible diagnostic marker parameter(s). Design: Collection of blood samples from mood disorder patients and age-matched control volunteers.Preparation of erythrocyte membranes for the proposed studies. Setting: Out patients / in patients, psychiatry ward, Civil Hospital, Ahmedabad, Gujarat, India, Department of Biochemistry, Faculty of Science, M.S.University of Baroda, Vadodara, Gujarat, India. Subjects: Unipolar and bipolar subjects. Control subjects (randomly selected volunteers). Results: The most significant results were a duration dependent decrease in the TPL/CHL ratio (mole:mole),changes in both the substrate and temperature kinetics properties of AChE and elevated plasma BChE activity in the mood disorder patients. Conclusion: The results suggest that the altered lipid profiles and the TPL/CHL (mole: mole) ratio and the altered temperature-dependent activity coefficients of erythrocyte membrane AChE and elevated plasma BChE activities could serve as useful diagnostic pointers for mood
TNFR2 expression on CD25 FOXP3 T cells induced upon TCR stimulation of CD4 T cells identiﬁes maximal cytokine-producing effectors hi +

In this study, we show that CD25 hi TNFR2 + cells can be rapidly generated in vitro from circulating CD4 lymphocytes by polyclonal stimuli anti-CD3 in the presence of anti-CD28.The in vitro induced CD25 hi TNFR2 + T cells express a conventional regulatoryT cells phenotype FOXP3 + CTLA4 + CD127 lo/ − , but produce effector and immunoregulatory cytokines includ-ing IL-2, IL-10, and IFN-g.These induced CD25 hi TNFR2 + T cells do not suppress target cell proliferation, but enhance it instead. Thus the CD25 hi TNFR2 + phenotype induced rapidly following CD3/28 cross linking of CD4T cells identiﬁes cells with maximal proliferative and effector cytokine-producing capability. The in vivo counterpart of this cell population may play an important role in immune response initiation.
ANESTHESIA AND ANALGESIA MANAGEMENT PROFILE FOR AIRWAY SURGERIES AT DR.

Introduction: Ear, Nose, and Throat (ENT) surgeries are commonly performed and very often require the surgeon and anesthesiologist to share the same workspace. Over the years, ENT surgery techniques have evolved from conventional methods to computer-assisted intraoperative navigation. In contrast to the past, a minimally invasive approach to paranasal sinus and petrous bone surgery is now preferred. Bleeding, postoperative nausea, and vomiting are complications often encountered in ENT surgery. In addition, pain management during surgery and patient comfort after a surgical procedure is a challenge for anesthesiologists. Therefore, the choice of anesthetic drugs is important. Objective: This study aims to determine the action profile, anesthetic management, and pain management in ENT surgery at Dr. Soetomo General Academic Hospital Surabaya . Materials and Methods: This is a retrospective descriptive study . A total of 177 patients underwent airway surgery . Data were obtained from the Medical Records of the Integrated Surgery Center of Dr. Soetomo General Academic Hospital recorded from January to December 2021. Results and Discussion: Most of the patients were in the age group of 45 - 65 years (40.1%) and a majority were men (65.5%). Most patients who were ≥ 20 years old had a normal nutritional status (54.2%). The most frequent diagnosis was laryngeal cancer (23%), with micro laryngeal surgery being the most frequently performed (35.8%). Most surgeries also needed less than 60 minutes followed by 60 to 119 minutes (27.1%). The most frequently used induction agents were a combination of propofol, fentanyl, and rocuronium (39.5%), with isoflurane as the most frequent inhalation agent (91.3%). Metamizole (70.1%) was the most postoperative analgesic. Conclusion: In general, intravenous agents were used for anesthesia induction. A combination of different induction agents brings synergistic benefits.
Prototipo formulación la cepa antagonista Pseudomonas fluorescens Ps006 Formulation prototype and atmosphere packaging for the antagonistic strain Pseudomonas fluorescens PS006

The isolation Pseudomonas fluorescens PS006 demonstrated high potential to be used as an active ingredient of a bio- produt, because its capacity to produce biosurfactants, its phosphorus solubilizing activity and its antagonistic activity over different phytopathogens. For this reason, the present work had as objectives to develop and characterize a formulation prototype based on P. fluorescens PS006, stable under storage conditions. Initially the active ingredient was characterize and compatible formulation auxiliaries, were selected evaluating the stability of its mixture with three solid diluents at two different moistures (10% and 20 %) during three months of storage at temperatures of 8, 18 and 28 ± 2 °C. The active ingredient showed in vitro biocontrol activity over four phytopathogens and temperature and humidity affected its stability during storage. Stability of the most stable formulation prototypes in terms of viability and biocontrol activity was evaluated in presence and absence of oxygen and membrane protectors. Support S1 with 20% of moisture mixed with the active ingredient without addition of membrane protectors and stored in presence of oxygen, was selected as the most stable treatment during six months of storage at three temperatures, with viability losses lower than 5%.
Pneumococcal conjugate vaccine-induced regulatory T cells suppress the development of allergic airways disease

Background Infections with some bacteria, including Streptococcus pneumoniae , have been associated with a reduced incidence of asthma. Components of S pneumoniae may have the potential to modulate allergic inﬂammatory responses and suppress the development of asthma. Objectives To determine if human S pneumoniae vaccines have the potential to suppress asthma by elucidating their effect on allergic airways disease (AAD) in mouse models. Methods AAD was induced in BALB/c mice by intraperitoneal sensitisation and intranasal challenge with ovalbumin. Pneumococcal conjugate or polysaccharide vaccines were administered at the time of sensitisation or during established AAD. Hallmark features of AAD were assessed. Levels of regulatory T cells (Tregs) were quantiﬁed by ﬂuorescence-activated cell sorting, and their immunoregulatory capacity was assessed using proliferation assays and anti-CD25 antibody treatment. Results Intranasal administration of the conjugate vaccine, but not the polysaccharide vaccine, suppressed the hallmark features of AAD, including: eosinophilic and T helper 2-mediated inﬂammation; airway hyper-responsiveness; circulating immunoglobulin E (IgE) levels; and mucus hypersecretion. Intramuscular administration of the conjugate vaccine had limited protective effects. The conjugate vaccine increased Tregs in the lung-draining lymph nodes, lung and spleen. Furthermore, conjugate vaccine-induced Tregs had an enhanced capacity to suppress T effector responses. Anti-CD25 administration reversed the suppressive effects of the conjugate vaccine. Conclusions A currently available human conjugate vaccine suppresses the hallmark features of AAD through the induction of Tregs. Thus targeted administration may provide a novel immunoregulatory treatment for asthma. before or after OVA sensitisation (Supplementary ﬁ gure 2). These data suggest that the effects of treatment persist and last for at least 26 days. The backbone components (AlPO 4 +CRM197) of the conjugate vaccine did not suppress the development of AAD (Supplementary ﬁ gure 3).
A Teledentistry Pilot Study on Patient-Initiated Care

COVID-19 has challenged the public dental workforce in their ability to continue providing routine oral health care services. To mitigate the risk of COVID-19 transmission to staff and patients, Teledentistry was implemented in many parts of the world, mainly to provide remote consultations, undertake triage, and offer preventive educational sessions. The aim of this paper is to describe Dental Health Services Victoria’s (DHSV) patient-initiated Teledentistry model of care implemented during peak COVID transmission in Victoria. The Teledentistry model supported patient-centered care involving active collaboration and shared decision making between patients, families, and clinicians in designing and managing remote care plans. DHSV’s eligible patient cohort includes disadvantaged population groups with greater oral health needs. Strong emphasis was placed on the simplicity and user friendliness of the Telehealth platform, as well as the support for patients with low technology literacy. Consumers and dental workforce were consulted and modifications to the use of language and services were undertaken before the launch. A total of 2492 patients accessed Telehealth services between May 2020 and April 2021. Approximately 39% of patients were born in a country other than Australia. A total of 489 patient-reported experience measures (PREMs) were received. Patients agreed or strongly agreed that the care they received met their needs (87%); they received answers to their questions (89%); they left their visit knowing what is next (87%); they felt they were taken care of during their visit (90%); and they felt involved in their treatment (89%). Teledentistry enabled patients to initiate access to care and consult with dental workforce remotely and safely during peak pandemic.
OTT_A_255956 9185..9201

1Department of Colorectal Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, People’s Republic of China; 2Department of Pathology, Fujian Medical University Union Hospital, Fuzhou, People’s Republic of China; 3Department of Radiology, Fujian Medical University Union Hospital, Fuzhou, People’s Republic of China; 4Department of General Surgery, The First Hospital of Fuzhou City Affiliated Fujian Medical University, Fuzhou, People’s Republic of China
Investigating epileptiform activity associated with slow wave sleep

The characteristic EEG trait of patients with nocturnal idiopathic epilepsies during childhood is the spike and wave discharge. Cognitive dysfunction is prevalent among these patients and is thought to be linked to disturbances in memory consolidation processes that normally occur during slow wave sleep. Several genetic mutations of nicotinic receptor subunits have been linked to these disorders. However, there is little known about the underlying mechanisms or the spatiotemporal characteristics of this epileptiform activity within the neocortex. This thesis presents a rat in vitro model of the epileptiform activity synonymous with nocturnal childhood epilepsies, that allows for pharmacological manipulation of receptor subunits linked to these disorders. The application of DTC [10μM], a non-selective, competitive nicotinic acetylcholine receptor antagonist, to an in vitro model of the cortical delta rhythm induced two individual forms of paroxysm events wave discharges and the conventional spike and wave discharges. Pharmacological manipulation of this model suggest that the epileptiform activity is mediated by excitatory currents which is consistent with the use of glutamate antagonists as anticonvulsants. A blanket blockade of inhibition by a GABAA antagonist resulted in severe discharges, hence hugely increasing excitatory response. Only partial disinhibition is suggested to be required to generate epileptiform activity as nicotinic acetylcholine receptors and 5-HT3 receptors are located on dendrite targeting interneurons. Mapping of unit activity revealed the difference between the two paroxysm events was recruitment of superficial layers with simultaneous paroxysm events in delta frequency-generating Layer V pyramidal cells. It is proposed that the hyperexcitability responsible for the generation of the spike component of a spike and wave discharge is mediated by the lack of excitatory tone in 5-HT3 and nicotinic acetylecholine receptor expressing inhibitory interneuron subtypes. The disinhibition, spike generation and disruption of interplay between deep and superficial layers of the neocortex is thought to be associated with synaptic plastic changes.
Intense electrostatic waves near the upper hybrid resonance frequency. Progress report

Plasma wave measurements using instruments on the Imp 6 and Hawkeye 1 satellites are utilized in a study of very intense electrostatic waves near the upper hybrid resonance frequency in the region just outside the plasmapause. These intense plasma wave events have electric field strengths of approx.1--20 mV m/sup -1/ 140 of these intense electrostatic disturbances reveal that the events occur at all local times and at magnetic latitudes varying from the equator to as high as 50/sup 0/. The polarization of these waves is such that the wave electric field vector is oriented perpendicular to the geomagnetic field. In most cases the center frequency of the intense waves appears to correspond to an (n+1/2) f/sub g/ harmonic near the upper hybrid resonance frequency. A survey of plasma measurements made simultaneously using the Hawkeye 1 Lepedea shows that the occurrence of the intense electrostatic waves is not strongly controlled by the intensities of approx.1-to 20-keV electrons but that specific details of the hot electron distribution function are directly related to the wave turbulence. All events at magnetic latitudes less than about 10/sup 0/ show strong pitch angle anisotropy with the greatest intensities at . cap alpha.approx. =90/sup 0/. The hot distributionmore » function f (upsilon/sub perpendicular/, upsilon/sub parallel/) is described for a few events showing two sources of free energy: a temperature anisotropy and a loss cone distribution. One event shown suggests that a bump on tail in upsilon/sub 1/ may also contribute free energy in some cases. A possible mechanism for producing intense waves near the upper hybrid resonance frequency is suggested which draws upon current theories applied to the generation of (n+1/2) f/sub g/ bands. Evidence is given which suggests that the intense electrostatic waves may be a source of nonthermal continuum radiation. « less
ANNALES DE L’INSTITUT FOURIER The polynomial and minimal diagrams of surface links

— We prove a Kauﬀman–Murasugi–Thistlethwaite theorem for al- ternating links in thickened surfaces. It implies that any reduced alternating diagram of a link in a thickened surface has minimal crossing number, and any two reduced alternating diagrams of the same link have the same writhe. This result is proved more generally for link diagrams that are adequate, and the proof involves a two-variable generalization of the Jones polynomial for surface links deﬁned by Krushkal. The main result is used to establish the ﬁrst and second Tait conjectures for links in thickened surfaces and for virtual links. pour dans im-plique que tout diagramme réduit d’entrelacs alternant dans une surface a un nombre minimal de croisements, et que deux diagrammes réduits alternants quel-conques du même entrelacs ont le même nombre d’auto-enlacements. Ce résultat est prouvé plus généralement pour les diagrammes d’entrelacs qui sont adéquats, et sa démonstration utilise une généralisation à deux variables du polynôme de Jones pour les entrelacs sur des surfaces déﬁnies par Krushkal. Le résultat principal est utilisé pour établir la première et la deuxième conjecture de Tait pour les entrelacs dans des voisinages tubulaires d’une surface et pour les entrelacs virtuels.
Random Matrix Theory with Applications in Statistics and Finance

This thesis investigates a technique to estimate the risk of the mean-variance (MV) portfolio optimization problem. We call this technique the Scaling technique. It provides a better estimator of the risk of the MV optimal portfolio. We obtain this result for a general estimator of the covariance matrix of the returns which includes the correlated sampling case as well as the independent sampling case and the exponentially weighted moving average case. This gave rise to the paper, [CMcS]. Our result concerning the Scaling technique relies on the moments of the inverse of compound Wishart matrices. This is an open problem in the theory of random matrices. We actually tackle a much more general setup, where we consider any random matrix provided that its distribution has an appropriate invariance property (orthogonal or unitary) under an appropriate action (by conjugation, or by a left-right action). Our approach is based on Weingarten calculus. As an interesting byproduct of our study and as a preliminary to the solution of our problem of computing the moments of the inverse of a compound Wishart random matrix, we obtain explicit moment formulas for the pseudo-inverse of Ginibre random matrices. These results are also given in the paper, [CMS]. Using the moments of the inverse of compound Wishart matrices, we obtain asymptotically unbiased estimators of the risk and the weights of the MV portfolio. Finally, we have some numerical results which are part of our future work.
Distinguishing Causes of Neighborhood Racial Change: A Nearest Neighbor Design

US neighborhoods remain largely stratiﬁed by race. The role of racial preferences in driving contemporary neighborhood racial change, however, remains surprisingly controversial. While theories of tipping typically emphasize racial preferences as a principal catalyst for neighborhood change, the emergence of gentriﬁcation and related processes in reshaping modern neighborhoods has led some to conclude that race is now of secondary importance. Reconciling these distinct views empirically has proven tough since credibly distinguishing whether households respond directly to the attributes of their neighbors or factors coincidental with the entry of new neighbors is difﬁcult. This paper introduces a novel “nearest neighbor” research design that isolates a component of the household decision to move out of a neighborhood directly attributable to the identities of their neighbors. In particular, we contrast the move rate of homeowners who live immediately nearby a new entrant of a different race to that of homeowners who live further away on the same block . This within-block comparison helps holds constant many other aspects of the neighborhood and its expected future evolution. Combining detailed data on housing transactions and race in North Carolina between 2005 and 2015, we estimate the causal effect of receiving a different race neighbor on the likelihood of moving. The results suggest that Black and white homeowners are signiﬁcantly more likely to move in response to receiving a close neighbor of a different race. How-ever, this effect is heterogeneous across household types: while older white households exhibit the strongest exit responses overall, among Blacks, younger households exhibit relatively high move rates. Move reactions among both Black and white households are stronger for homeowners born in the North or Midwest, where residential segregation is especially high, compared to those born in the South. based on contrasting the move decisions of households within the same Census block group who receive a new Democratic versus Republican neighbors to study political polarization. Bayer et al. (2008), Bayer et al. (2021), and McCartney and Shah (2022) use a related research design based on contrasts between households on the same block versus a block or two away to study the role of neighborhood social interactions on job referrals, household ﬁnance, and investment activity. In these papers, the thinness of the owner-occupied housing market provides the primary basis for the argument that the assignment of neighbors at such ﬁne geographic scales is quasi-random. a of their We present a series of auxiliary analyses related to
REF: Submission of manuscript “Identification of Ankle Sprain Motion from Normal Activities by Dorsal Foot Kinematics Data”

This study presented a method to identify ankle sprain motion from common sporting activities by dorsal foot kinematics data. Six male subjects performed 300 simulated supination sprain trials and 300 non-sprain trials in a laboratory. Eight motion sensors were attached to the right dorsal foot to collect three-dimensional linear acceleration and angular velocity kinematics data, which were used to train up a Support Vector Machine (SVM) model for the identification purpose. Results *Manuscript
From Believing to Sharing: Examining the Effects of Partisan Media’s Correction of COVID-19 Vaccine Misinformation

Drawing on social identity theory and politeness theory, this study tested the effects of partisan media’s correction of COVID-19 vaccine misinformation on individuals’ message credibility perceptions and news engagement intentions. Based on a between-subjects online experiment in the United States, we found that partisans exposed to ingroup media perceived corrective messages as more credible (marginally) and held higher news engagement intentions than those exposed to outgroup media; nonpartisans rated corrective messages on partisan media as less credible and were less likely to engage than partisans. It also revealed that message credibility mediated the effects of exposure condition on news engagement intentions. Further, the results show that types of risk quantifiers moderated the direct effects of exposure condition on message credibility perceptions and the indirect effects on news engagement intentions via message credibility perceptions. We discuss the findings in light of how news media could combat misinformation in a polarized society. exposure condition on news engagement intentions through message credibility perceptions. Based on two pairwise mediation analyses with 5,000 bootstrap resamples, we found that partisans in the ingroup media condition had higher message credibility perceptions, which, in turn, led to greater news engagement intentions as compared to partisans in the outgroup media condition ( b = 0.23, bootstrapped SE = 0.10, 95% CI = [0.04, 0.41]) and nonpartisans ( b = 0.44, bootstrapped SE = 0.13, 95% CI = [0.20, 0.72]). Hence, H3a–b were supported.
Diﬀerent shear regimes in the dense granular ﬂow in a vertical channel

The steady dense granular ﬂow in a vertical channel bounded by ﬂat frictional walls in one horizontal direction and with periodic boundary conditions in the other horizontal and vertical directions is studied using the discrete element method. The shape of the scaled velocity proﬁle is characterized quantitatively by a universal exponential function, and the ratio of the maximum and slip velocities is independent of the average volume fraction ¯ φ and the channel width W . For sufﬁciently wide channels, the maximum and slip velocities increase proportional to √ W , and the thickness of the shearing zones increases proportional to W . There are four zones in the ﬂow, each with distinct dynamical properties. There is no shear in the plug zone at the centre, but there is particle agitation, and the volume fraction φ is lower than the random close packing volume fraction φ rcp . In the adjoining dense shearing zone, φ is greater than the volume fraction for arrested dynamics φ ad = 0 . 587, and the granular temperature and shear rate depend on the particle stiffness. Adjacent to the dense shearing zone is the loose shearing zone where φ < φ ad . Here, the properties do not depend on the particle stiffness, and the constitutive relations are well described by hard-particle models. The rheology in the loose shearing zone is similar to the dense ﬂow down an inclined plane. There is high shear and a sharp decrease in φ in the wall shearing zone of thickness about two particle diameters, where the particle angular velocity is different from the material rotation rate due to the presence of the wall.