Miracle-dz/UniFAR-FTUs huggingface dataset:
Iron folic acid supplementation adherence level and its associated factors among pregnant women in Ethiopia: a multilevel complex data analysis of 2019 Ethiopian mini demographic and health survey data

Background Iron and folic acid deficiency is a worldwide public health concern, particularly in low and middle-income countries. In Ethiopia, adherence to iron and folic acid supplements is still very low. Despite the fact that a number of studies on IFA supplementation have been conducted in Ethiopia, they do not indicate a nationwide problem and do not use advanced models to demonstrate clustering effects. The purpose of this study was to assess the level of non-adherence to iron folic acid supplementation and predictors among pregnant women in Ethiopia. Objective To assess iron folic acid supplementation adherence level and its associated factors among pregnant women in Ethiopia using data from the 2019 Mini-Ethiopian demographic health survey. Methods The Mini Ethiopian Demographic and Health Survey 2019 data were obtained from the official database website of the Demographic and Health Survey program (http://dhsprogram.com). The analysis included a sample of 2,356 weighted study participants. A multivariable multilevel mixed-effects logistic regression model was used Variables with p-values less than 5%) was reported as statistically significant variables in the multivariable analysis. Results The proportion of mothers who did not adhere to iron and folic acid supplements was 81.03% (95 %CI, 79.39, and 82.56). Birth interval less than 2 years [AOR: 2.03; 95% CI: 1.12, 3.66], women ever born less than six children [AOR: 1.99; 95% CI: 1.09, 3.64], starting ANC visit during first trimester [AOR: 2.74; 95 %CI: 1.03, 7.30], region [AOR = 0.24; 95% CI: 0.10], and having a high no ANC visit in the community [AOR = 1.77; 95% CI: 1.08, 2.88] were statistically significant factors. There was Intra-Custer Correlation (ICC = 17.72%), indicating that 17.72% variability in non-adherence levels was due to clusters. Conclusion and recommendation In Ethiopia, nearly four out of every five pregnant women did not receive iron folic acid supplementation for the recommended periods. Birth intervals, number of children, timing of ANC visits, region, and community level no ANC service were significant factors for non-adherence IFAS. As a result, the community, govern metal and non-governmental sectors enacting on health should focus on reducing non-adherence through tailored interventions on factors that influence it.
Cholangiocarcinoma: Recent Advances in Molecular Pathobiology and Therapeutic Approaches

Simple Summary Cholangiocarcinoma (CCA) manifests as a complex interplay of genetic and environmental factors, necessitating personalized approaches. This review covers the various causes, risk factors, and molecular aspects of CCA in oncology. It explores current diagnostic methods and treatments, such as targeted therapies and immunotherapy. Additionally, it addresses emerging strategies like microbiota modulation and the use of natural compounds. This review paper provides a comprehensive understanding of CCA, offering insights into current and evolving approaches for effective interventions in oncological care. Abstract Cholangiocarcinomas (CCA) pose a complex challenge in oncology due to diverse etiologies, necessitating tailored therapeutic approaches. This review discusses the risk factors, molecular pathology, and current therapeutic options for CCA and explores the emerging strategies encompassing targeted therapies, immunotherapy, novel compounds from natural sources, and modulation of gut microbiota. CCA are driven by an intricate landscape of genetic mutations, epigenetic dysregulation, and post-transcriptional modification, which differs based on geography (e.g., for liver fluke versus non-liver fluke-driven CCA) and exposure to environmental carcinogens (e.g., exposure to aristolochic acid). Liquid biopsy, including circulating cell-free DNA, is a potential diagnostic tool for CCA, which warrants further investigations. Currently, surgical resection is the primary curative treatment for CCA despite the technical challenges. Adjuvant chemotherapy, including cisplatin and gemcitabine, is standard for advanced, unresectable, or recurrent CCA. Second-line therapy options, such as FOLFOX (oxaliplatin and 5-FU), and the significance of radiation therapy in adjuvant, neoadjuvant, and palliative settings are also discussed. This review underscores the need for personalized therapies and demonstrates the shift towards precision medicine in CCA treatment. The development of targeted therapies, including FDA-approved drugs inhibiting FGFR2 gene fusions and IDH1 mutations, is of major research focus. Investigations into immune checkpoint inhibitors have also revealed potential clinical benefits, although improvements in survival remain elusive, especially across patient demographics. Novel compounds from natural sources exhibit anti-CCA activity, while microbiota dysbiosis emerges as a potential contributor to CCA progression, necessitating further exploration of their direct impact and mechanisms through in-depth research and clinical studies. In the future, extensive translational research efforts are imperative to bridge existing gaps and optimize therapeutic strategies to improve therapeutic outcomes for this complex malignancy.
Primary signet ring cell carcinoma of the cervix: case report and literature review

Objective To report an infrequent case of primary signet ring cell carcinoma of the cervix (PSRCC), review the literature and evaluate the clinicopathological characteristics. Material and methods A 51-year-old female patient, with 3 years of disease characterised by gynaecologic bleeding and pelvic pain. On examination, cervix replaced by tumour and infiltrated parametria; with cytology and histology of adenocarcinoma with cells in a signet ring pattern. Disease extension studies were negative. Classified as PSRCC stage IIIB, chemotherapy and radiotherapy were indicated, but the patient died a month later. The bibliographic search included publications up to July 2023. Results 32 cases with a mean age of 47.6 years were identified. The most frequent symptoms were uterine bleeding and abdominal and pelvic pain. The initial stages were treated surgically, some with adjuvant chemotherapy and/or radiotherapy, with favourable responses; a difference from advanced cases. The average survival was 17.6 months. Conclusion PSRCC is rare, with 32 cases reported according to the review. The expression with immunohistochemical and molecular techniques for the human papilloma virus can help confirm the gynaecological primary, but its diagnosis is one of exclusion, since its morphological pattern is related to other primaries, mainly digestive.
Promoting positive youth development and well-being: lesson learned from youth integrated health post in Indonesia

Indonesia is a multicultural country with many indigenous people, including the Tengger tribe, who live in the mountainous area called Tosari. Limited access in rural areas and various risky behavior are the challenges for youth to develop optimally. To fill this gap, Tosari youth, together with midwives and the village office, initiated a youth-integrated health post called posyandu youth (PR), which was adapted to local culture. This study determined outcomes, program quality, and the possibility of PR program development using the positive youth development (PYD) framework. This study employed a qualitative design with a case study approach. From semi-structured interviews with various key stakeholders of PR, findings reveal a connection between the PR program quality and the positive health and well-being outcomes among participants. Based on these findings, several recommendations for maximizing PR as a youth development program to improve PYD and well-being among indigenous youth are provided.
Generation Conditions of Dacite and Rhyodacite via the Crystallization of an Andesitic Magma. Implications for the Plumbing System at Santorini (Greece) and the Origin of Tholeiitic or Calc-alkaline Differentiation Trends in Arc Magmas

Andesitic arc volcanism is the most common type of subduction-related magmatism on Earth. How these melts are generated and under which conditions they evolve towards silica-rich liquids is still a matter of discussion. We have performed crystallization experiments on a representative andesite sample from the Upper Scoriae 1 (USC-1) eruption of Santorini (Greece) with the aim of understanding such processes. Experiments were performed between 1000 and 900 °C, in the pressure range 100–400 MPa, at fO2 from QFM (quartz–fayalite–magnetite) to NNO (nickel–nickel oxide) + 1·5, with H2Omelt contents varying from saturation to nominally dry conditions. The results show that the USC-1 andesitic magma was generated at 1000 °C and 12–15 km depth (400 MPa), migrated to shallower levels (8 km; 200 MPa) and intruded into a partially crystallized dacitic magma body. The magma cooled to 975 °C and generated the phenocryst assemblage and compositional zonations that characterize the products of this eruption. An injection of basaltic magma problably subsequently triggered the eruption. In addition to providing the pre-eruptive conditions of the USC-1 magma, our experiments also shed light on the generation conditions of silica-rich magmas at Santorini. Experimental of runs performed at fO2 ∼ NNO + 1 (± 0·5) closely mimic the compositional evolution of magmas at Santorini whereas those at reduced conditions (QFM) do not. Glasses from runs at 1000–975 °C encompass the magma compositions of intermediate-dominated eruptions, whereas those at 950–900 °C reproduce the silicic-dominated eruptions. Altogether, the comparison between our experimental results and natural data for major recent eruptions from Santorini shows that different magma reservoirs, located at different levels, were involved during highly energetic events. Our results suggest that fractionation in deep reservoirs may give rise to magma series with a tholeiitic signature whereas at shallow levels calc-alkaline trends are produced.
Predicting gestational age at birth in the context of preterm birth from multi-modal fetal MRI

Preterm birth is associated with significant mortality and a risk for lifelong morbidity. The complex multifactorial aetiology hampers accurate prediction and thus optimal care. A pipeline consisting of bespoke machine learning methods for data imputation, feature selection, and regression models to predict gestational age (GA) at birth was developed and evaluated from comprehensive multi-modal morphological and functional fetal MRI data from 176 control cases and 67 preterm birth cases. The GA at birth predictions were classified into term and preterm categories and their accuracy, sensitivity, and specificity were reported. An ablation study was performed to further validate the design of the pipeline. The pipeline achieves an R2 score of 0.51 and a mean absolute error of 2.22 weeks. It also achieves a 0.88 accuracy, 0.86 sensitivity, and 0.89 specificity, outperforming previous classification efforts in the literature. The predominant features selected by the pipeline include cervical length and various placental T2* values. The confluence of fast, motion-robust and multi-modal fetal MRI techniques and machine learning prediction allowed the prediction of the gestation at birth. This information is essential for any pregnancy. To the best of our knowledge, preterm birth had only been addressed as a classification problem in the literature. Therefore, this work provides a proof of concept. Future work will increase the cohort size to allow for finer stratification within the preterm birth cohort.
Nicotinic acetylcholine receptor CHRNA5 is overexpressed in head and neck squamous cell carcinoma patients with a recent tobacco smoking history.

Tobacco smoking is a major driver of head and neck squamous cell carcinoma (HNSCC) occurrence, and previous studies have shed light on the precise molecular alterations in tobacco-related HNSCCs when compared to HNSCCs associated with other risk factors (ex: human papillomavirus/HPV status). In this study, we analyzed the gene expression differences in HNSCC cases with a recent smoking history and revealed that the nicotinic acetylcholine receptor CHRNA5 is differentially overexpressed in smoking-related HNSCCs. CHRNA5 overexpression in these HNSCCs corresponds with a worse prognosis and is inversely correlated with an immune expression signature commonly associated with better prognosis. From these results, our study highlights the potential role of the nicotine-activated CHRNA5 receptor in HNSCC progression and corresponds with other recent reports highlighting the potential role of nicotine induction in promoting cancer progression.
Retroperitoneal paraduodenal unicentric Castleman disease: case report and review of the literature

Abstract Castleman disease is a rare and benign disorder, characterized by enlarged lymph nodes and angiofollicular lymphoid hyperplasia. We report a case of a 57-year-old male, who was admitted to our surgical department because of a retroperitoneal nodular mass measuring about 4 cm in maximum diameter, incidentally discovered on a radiologic exam performed for the onset of vague abdominal pain with posterior irradiation. The patient was subdue to laparoscopic removal of the mass and no intra- and post-operative complications were recorded. Histologic diagnosis of hyaline-vascular variant of the Castleman disease was confirmed. Only two cases have been found in the literature reporting the paraduodenal unicentric Castleman disease localization like our case. Although rare, the Castleman disease must be considered in the differential diagnosis among all the lymph nodes diseases, for avoiding improper therapies.
Impact of penicillin allergy labels on surgical site infections in a large UK cohort of gastrointestinal surgery patients

Abstract Objectives Studies in the USA, Canada and France have reported higher surgical site infection (SSI) risk in patients with a penicillin allergy label (PAL). Here, we investigate the association between PALs and SSI in the UK, a country with distinct epidemiology of infecting pathogens and range of antimicrobial regimens in routine use. Methods Electronic health records and national SSI surveillance data were collated for a retrospective cohort of gastrointestinal surgery patients at Cambridge University Hospitals NHS Foundation Trust from 1 January 2015 to 31 December 2021. Univariable and multivariable logistic regression were used to examine the effects of PALs and the use of non-β-lactam-based prophylaxis on likelihood of SSI, 30 day post-operative mortality, 7 day post-operative acute kidney injury and 60 day post-operative infection/colonization with antimicrobial-resistant bacteria or Clostridioides difficile. Results Our data comprised 3644 patients and 4085 operations; 461 were undertaken in the presence of PALs (11.3%). SSI was detected after 435/4085 (10.7%) operations. Neither the presence of PALs, nor the use of non-β-lactam-based prophylaxis were found to be associated with SSI: adjusted OR (aOR) 0.90 (95% CI 0.65–1.25) and 1.20 (0.88–1.62), respectively. PALs were independently associated with increased odds of newly identified MRSA infection/colonization in the 60 days after surgery: aOR 2.71 (95% CI 1.13–6.49). Negative association was observed for newly identified infection/colonization with third-generation cephalosporin-resistant Gram-negative bacteria: aOR 0.38 (95% CI 0.16–0.89). Conclusions No evidence was found for an association between PALs and the likelihood of SSI in this large UK cohort, suggesting significant international variation in the impact of PALs on surgical patients.
Effects of Soil Water Contents on Nutrient Uptake and Allocation of Baldcypress

One year old seedlings of baldcypress (Taxodium distichum) were grown in pots under greenhouse conditions with varying soil water contents (W_1,flooding;W_2,waterlogging;W_3,75% of field water capacity;W_4,50% of field water capacity;W_5,25% of field water capacity) to study the effects of soil water contents on nutrient uptake and allocation of baldcypress. The treatment lasted 130 days, and the results are as follows: (1)The total N concentration of root, stem and leaf of baldcypress increased with increasing of soil water contents, and the total P concentration of root, stem and leaf of W_3 among five water treatments was the lowest, flooding or drought stress increased the total P concentration, and the total Ca, K, Na, Mg and Fe concentration in root, stem and leaf had different changing tendency; (2) The order of total N, P, Ca, K, Na, Mg and Fe concentration in root, stem and leaf was in the order of leafrootstem; (3) The total accumulation of nutrients in baldcypress decreased with decreasing of soil water contents, and the allocation ratio of root and stem increased with decreasing of soil water contents, while the allocation ratio of leaf decreased significantly with decreasing of soil water contents.
Shallow-water acoustics investigations for underwater detection and seabed imaging

This paper is concerned with the problem of recognition of objects laying on the seabed and presented on echosounder images. Considering that high resolution echosounder system provides acoustic images of high-quality, this research have been interested in shallow water investigations for underwater objects. This work presented recent detection algorithms for coral reef, seagrass, and seabed using signal processing. Acoustic reflectivity and backscatter strength of coral reef were higher than seagrass. The lifeform of coral reef had different acoustic intensity value.
Association between Myometrial Thickness and Assisted Reproductive Technologies Outcomes: A Prospective Cohort Study

Background: Myometrial thickness has been expected to be a prognosticator for lower uterine segment function. An abnormal function of the uterine muscle layer can cause common and important reproductive problems. This study aimed to evaluate the relationship between baseline myometrial thickness and assisted reproductive technologies (ART) outcomes. Materials and Methods: In this prospective cohort study, 453 infertile women undergoing ART cycles without any obvious uterine pathology, participated in this prospective cohort study from February 2013 to May 2015. In order to measure the myometrial thickness in the anterior and posterior of the uterine, trans-vaginal ultrasounds were conducted on days 2-4 of the cycle (menstrual phase) preceding ovarian stimulation and the day of human chorionic gonadotropin (hCG) injection. We defined three groups based on the baseline myometrial thickness in the anterior and posterior, including (A) <25 mm, (B) 25-29.9 mm and (C) ≥30 mm. Ovarian stimulation, oocyte retrieval and luteal phase support were performed in accordance with the standard long protocol. Two weeks after embryo transfer, the patients underwent a pregnancy test by checking their serum β-hCG levels. The primary outcome measure was the clinical pregnancy rate. Secondary outcome measures were, implantation rate, abortion rate and live birth rate. Results: The clinical pregnancy (P=0.013) and implantation (P=0.003) rates were significantly lower in the group A than in two other groups. Although, the live birth rate was lower in group A than two other groups, this decrease was not statistically significant (P=0.058). Conclusion: The findings may be a way for clinicians to draw focus on providing therapeutic strategies and a specific supportive care for women with a baseline myometrial thickness <25 mm in order to improve the reproductive outcome of in vitro fertilization/intracytoplasmic sperm injection (IVF-ICSI).
Detection of subclinical enthesitis by ultrasonography in patients with psoriasis and controls.

INTRODUCTION Psoriasis is a widespread chronic inflammatory skin disease; enthesitis is inflammation of the tendon, ligament, and joint capsule insertion, prevalent in patients with psoriatic arthritis. OBJECTIVES The aim of study to evaluate the utility of the Madrid Sonography Enthesitis Index scoring system for accurate detection of subclinical enthesitis in patients with Psoriasis compared with healthy controls. Another objective was to assess increase in enthesis area and Psoriatic arthritis incidence, in a prospective 1-year follow-up. METHOD Patients aged ≥18 years who were diagnosed with Psoriasis, without musculoskeletal complaints, and who did not have any clinical sign and/or symptom of enthesitis and synovitis were included in the study. The patients and healthy controls were evaluated with ultrasonography. Ultrasonography evaluation consisted of the detection of gray-scale enthesitis and power Doppler signal in the enthesis areas. The Madrid Sonography Enthesitis Index scoring system was used to quantify the extent of the sonographic enthesis abnormalities. RESULTS The mean MASEI score, structure, thickness, erosion, and calcification were significantly higher in the Psoriasis group than in the control group. The mean MASEI score, structure, erosion, and calcification measurements were significantly higher at the last examination when compared to the first examination. The triceps was the most commonly affected tendon in both groups. CONCLUSION Ultrasonography is an important tool for diagnosis and follow-up of subclinical enthesitis in patients with psoriasis. Regardless of disease duration and severity, patients should be screened using ultrasonography at yearly intervals.
Canals vs. Streams: To What Extent Do Water Quality and Proximity Affect Real Estate Values? A Hedonic Approach Analysis

The presence of and proximity to water influences human settlement decisions, because water has been able to characterize the environment and affect human health since prehistoric times. Many scholars have studied the effects of environmental amenities on the real estate market; however, only a few of them have explored the effects of water. This study stresses the role of water with a focus on the dichotomy between artificial and natural waterways (canals vs. streams), which involves managerial and qualitative differences. A hedonic approach, based on a large web scraped and geo-referenced dataset of 10,530 observations, is used to analyze the effect of water proximity and quality on residential housing prices in the province of Milan (Italy). Our main results show a significant but conflicting impact of water proximity on real estate value: reducing the canal distance, we observe an increase in the residential housing sale price, in urban more than peri-urban environments; in contrast, reducing the stream distance, our results show decreases in property value. Moreover, a significant moderating effect of water quality on distance from streams is identifiable.