Miracle-dz/UniFAR-FTUs huggingface dataset:
Functional and Structural Outcomes at the Foveal Avascular Zone with Optical Coherence Tomography Following Macula off Retinal Detachment Repair

Background Visual recovery following macula involving rhegmatogenous retinal detachment remains poorly understood. The aim of this work is to correlate the functional and the anatomical changes in retinal vasculature in the foveal avascular zone using optical coherence tomography angiography (OCTA) after successful retinal reattachment repair and correlate this data with retinal thickness and post-operative visual recovery. Methods A prospective, comparative observational study of 28 eyes of 14 patients with 14 eyes undergoing macula off retinal detachment repair with pars plana vitrectomy, endo-laser and silicone oil-based tamponade compared with 14 fellow healthy eyes at 1, 6 and 12 weeks post-operative period. The study was conducted at the Research Institute of Ophthalmology, Giza, Egypt between February 2018 and August 2018. Results The foveal avascular zone (FAZ) area in the patients group was not significantly different compared to the control group and was found to be negatively correlated with the central retinal thickness in both the study and control group. The superficial capillary plexus (SCP) area at the FAZ was significantly larger than the deep capillary plexus (DCP) area at the FAZ in both the study and control group over the follow-up period. The DCP area at the FAZ was significantly larger at the 3rd follow-up than the 1st follow-up. The SCP FAZ area was significantly larger than the DCP FAZ area in both the study and control group over the follow-up period. BCVA was found to be negatively correlated to the retinal thickness of the temporal 3 mm paracentral quadrant with no correlation with central foveal thickness (CFT) and the FAZ area. Conclusion Optical coherence tomography (OCT) and OCTA are valuable noninvasive imaging tools to monitor and predict the structural changes at the foveal avascular zone during the recovery phase after successful retinal reattachment involving macula.
Stars and gas in the most metal-poor galaxies – I. COS and MUSE observations of SBS 0335−052E

Among the nearest most metal-poor starburst-dwarf galaxies known, SBS 0335−052E is the most luminous in integrated nebular He ii λ4686 emission. This makes it a unique target to test spectral synthesis models and spectral interpretation tools of the kind that will be used to interpret future rest-frame UV observations of primeval galaxies. Previous attempts to reproduce its He ii λ4686 luminosity found that X-ray sources, shocks, and single Wolf–Rayet stars are not main contributors to the He ii-ionizing budget; and that only metal-free single rotating stars or binary stars with a top-heavy IMF and an unphysically low metallicity can reproduce it. We present new UV (COS) and optical (MUSE) spectra that integrate the light of four super star clusters in SBS 0335−052E. Nebular He ii, [C iii], C iii], C iv, and O iii] UV emission lines with equivalent widths between 1.7 and 5 Å and a C iv λλ1548, 1551 P-Cygni like profile are detected. Recent extremely metal-poor shock + precursor models and binary models fail to reproduce the observed optical emission-line ratios. We use different sets of UV and optical observables to test models of constant star formation with single non-rotating stars that account for very massive stars as blueshifted O v λ1371 absorption is present. Simultaneously fitting the fluxes of all high-ionization UV lines requires an unphysically low metallicity. Fitting the P-Cygni like + nebular components of C iv λλ1548, 1551 does not constrain the stellar metallicity and time since the beginning of star formation. We obtain 12+log(O/H)$\, = 7.45\pm 0.04$ and log(C/O)$\, = -0.45^{+0.03}_{-0.04}$ for the galaxy. Model testing would benefit from higher spatial resolution UV and optical spectroscopy of the galaxy.
Effects of Anisodine Hydrobromide on the Cardiovascular and Respiratory Functions in Conscious Dogs

Purpose Anisodine hydrobromide (Ani) is isolated from the medicinal plant Anisodus tanguticus (Maxim.) Pascher for clinical use. Although considerable research regarding Ani has been reported, the safety profiles of Ani are currently unknown. This study investigated the cardiorespiratory effects of Ani in conscious dogs to provide clinicians a detailed safety profile of Ani on the cardiorespiratory system. Materials and Methods Using the Latin square design, the study was divided into six phases, where in each phase, six telemetered beagle dogs received one dose of normal saline or sotalol hydrochloride or Ani (0.1, 0.4, 1.6, or 6.4 mg/kg). Electrocardiogram, blood pressure (BP) and respiratory parameters were collected before and after administration for 24 hours. Statistical comparisons were performed at scheduled time-points. Results The heart rate was significantly increased, PR and QTCV intervals were significantly shortened in Ani 0.4, 1.6, 6.4 mg/kg treatment group after drug administration. Compared with the saline group, a significant increase in heart rate and shortening of PR, QTCV intervals were observed in the Ani 1.6, 6.4 mg/kg treatment groups from 5 min to 4 h time-points. Diastolic and mean BP were significantly increased in Ani 1.6, 6.4 mg/kg from 1 h to 2 h time-points compared to those of the saline control. Accelerated breathing was observed in the first 20 min after Ani 0.4, 1.6, and 6.4 mg/kg treatment, although not statistically significant. Furthermore, no significant differences were observed in any of the corresponding indexes of Ani 0.1 mg/kg treatment group at different time-points compared to those of the saline group. Conclusion Ani may have adverse effects on the cardio-respiratory systems of dogs at doses above 0.4 mg/kg, whereas Ani 0.1 mg/kg was devoid of potentially deleterious effects on cardiorespiratory function.
Profiles of Vertebral Artery Dissection with Congenital Craniovertebral Junction Malformation: Four New Cases and a Literature Review

Objective Vertebral artery dissection (VAD) combined with congenital craniovertebral junction malformation (CVJM) is rare. This study aimed to analyze the etiology, clinical and imaging features, treatment, and prognosis of VAD with CVJM. Methods Four new cases of VAD with congenital CVJM and 28 similar cases found in the literature were included. Detailed clinical data from all cases were retrospectively analyzed. Results A total of 32 patients (28 men, four women; mean age 19.01±12.53 years) were included. Seventeen of 32 cases (53.1%) had had multiple ischemic episodes. The most common neurological symptoms were limb numbness/weakness (20/32), ataxia (15/32), and dizziness/vertigo (12/32). In sum, 31 of 32 cases had multiple infarcts scattered throughout the posterior circulation area on cranial computed tomography or resonance imaging. Dissection had occurred in the V3 segment of the VA in 29/31 cases (93.5%). The most common congenital CVJMs were atlantoaxial dislocation and atlantoaxial subluxation (found in 20/32 cases [62.5%]), while 27/32 cases (84.3%) had multiple combined abnormalities. Seven of eleven cases (63.6%) with initial antiplatelet treatment and one of eleven (9.1%) with initial anticoagulation treatment experienced stoke recurrence. Fusion or vertebral fixation was performed in 16 patients and aneurysm resection in one patient. There was no reported recurrence after surgery in 13 patients with follow-up data. Conclusion Underlying CVJM is a rare but overlooked etiology in VAD, and is prone to induce recurrent ischemic stroke. Patients with VAD, especially that localized in the V3 segment, should be examined for CVJM. Timely assessment is critical for determining the specific cause and to provide targeted intervention.
Tuberculosis Treatment Outcomes and Associated Factors Among Patients Treated at Woldia General Hospital in Northeast Ethiopia: An Institution-Based Cross-Sectional Study

Background Tuberculosis remains a major global health problem. It causes ill-health among millions of people each year and ranks alongside the human immunodeficiency virus (HIV) as a leading cause of death worldwide. For effective tuberculosis control, it is a prerequisite to detect the cases as early as possible and to ensure that the tuberculosis patients complete their treatment and get cured. However, the burden of the problem is still a national issue, and there is a scarcity of research to show treatment outcomes and associated factors of tuberculosis at the North Wollo Zone, specifically Woldia. Methods Institution-based, retrospective register-based data were collected from medical records of tuberculosis patients from 2015 up to 2018 at Woldia General Hospital. The data were analyzed using SPSS version 24, and multiple logistic regression methods were used to investigate the association between independent and dependent variables. A P-value of less than 5% was considered statistically significant in the final model. Results The prevalence of successful tuberculosis treatment outcomes was 80.7%. Among all patients, 73% were pulmonary tuberculosis cases. This study results show that age less than 24 years old [AOR: 4.7; 95% CI (1.3–10.1)], male sex [AOR: 2.8; 95% CI (2.1–4.8)], year of registration in 2018 [AOR: 4.8; 95% CI (3.9–7.4)], and HIV negative status [AOR: 3.9; 95% CI (1.4–10.7)] were found to be significantly associated factors with the treatment outcomes of tuberculosis. Conclusion The study showed that nearly 20% of tuberculosis patients had an unsuccessful treatment outcome. Older age, female sex, year of registration in 2015, and being HIV positive were found significantly associated with poor tuberculosis treatment outcomes. Therefore, targeted measures should be considered to decrease poor TB treatment outcomes among high-risk patients through careful monitoring, making the DOTs program more accessible, counseling, and linking HIV patients.
Assessment of Chronic Respiratory Health Symptoms and Associated Factors Among Flour Mill Factory Workers in Addis Ababa, Ethiopia, 2019: A Cross-Sectional Study

Background Flour mill workers are at high risk of developing respiratory symptoms due to exposure to flour dust in their working environment. Exposure to flour dust linked with the development of chronic respiratory disorders. However, very little evidence has been available on the respiratory symptoms of exposed workers in large-scale flour mill factories. Therefore, the aim of this study was to assess chronic respiratory health symptoms and associated factors among flour mill workers in Addis Ababa, Ethiopia. Methods Cross-sectional study was conducted among a sample of 424 randomly selected workers from Addis Ababa flour mill factories. Respiratory health symptoms were assessed using an American Thoracic Society standard questionnaire customized with local context. Data were checked for completeness and Epi-Info V. 7.2 and SPSS V.21 statistical software were used for data entry and analysis, respectively. Multivariable logistic regression model was used to identify variables associated with chronic respiratory health symptoms. Variables that had significant association were identified based on adjusted odds ratio (AOR) with 95% confidence interval (CI) and p <0.05. Data were presented using tables, texts and figures. Results The prevalence of chronic respiratory health symptoms among flour mill factory workers was 58.3% (95% CI: 53.7–63.4). Chronic respiratory health symptoms were significantly associated with age group (AOR=1.95, 95% CI; 1.17–2.79 and AOR=12.3, 95% CI; 4.39–34.6), monthly income (AOR=1.68, 95% CI; 1–2.79), work experience (AOR=2.58, 95% CI; 1–6.62), past dust exposure (AOR=1.86, 95% CI; 1.08–3.2) and utilization of respiratory protective equipment (AOR=2.29, 95% CI; 1.27–4.13). Conclusion and Recommendation Chronic respiratory health symptoms were highly prevalent among flour mill factory workers. Supportive supervision and cooperation between Ministry of Labour and Social Affairs, flour mill managers and workers are needed to reduce exposure and improve working environment.
Cancer-Derived Exosomes: Their Role in Cancer Biology and Biomarker Development

Abstract Exosomes are a subset of tiny extracellular vesicles manufactured by all cells and are present in all body fluids. They are produced actively in tumor cells, which are released and utilized to facilitate tumor growth. Their characteristics enable them to assist major cancer hallmarks, leveraged by cancer cells in fostering cancer growth and spread while implementing ways to escape elimination from the host environment. This review updates on the latest progress on the roles of cancer-derived exosomes, of 30–100 nm in size, in deregulating paracrine trafficking in the tumor microenvironment and circulation. Thus, exosomes are being exploited in diagnostic biomarker development, with its potential in clinical applications as therapeutic targets utilized in exosome‐based nanoparticle drug delivery strategies for cancer therapy. Ongoing studies were retrieved from PubMed® and Scopus database and ClinicalTrials.gov registry for review, highlighting how cancer cells from entirely different cell lines rely on genetic information carried by their exosomes for homotypic and heterotypic intercellular communications in the microenvironment to favor proliferation and invasion, while establishing a pre-metastatic niche in welcoming cancer cells’ arrival. We will elaborate on the trafficking of tumor-derived exosomes in fostering cancer proliferation, invasion, and metastasis in hematopoietic (leukemia and myeloma), epithelial (breast cancer), and mesenchymal (soft tissue sarcoma and osteosarcoma) cancers. Cancer-derived exosomal trafficking is observed in several types of liquid or solid tumors, confirming their role as cancer hallmark enabler. Their enriched genetic signals arising from their characteristic DNA, RNA, microRNA, and lncRNA, along with specific gene expression profiles, protein, or lipid composition carried by the exosomal cargo shed into blood, saliva, urine, ascites, and cervicovaginal lavage, are being studied as a diagnostic, prognostic, or predictive cancer biomarker. We reveal the latest research efforts in exploiting the use of nanoparticles to improve the overall cancer diagnostic capability in the clinic.
Two-Parametric Nyquist Pulses with Better Performance Based on Inverse Hyperbolic Functions

In this article, three new inter-symbol interference (ISI)-free pulses with enhanced performance compared to the state-of-the-art are proposed and studied in terms of frequency and time domain characteristics. They are based on inverse hyperbolic functions and on the concept of inner and outer functions, which was first introduced by the authors. New pulses are two-parametric, i.e., their design depends only on the roll-off factor and the timing jitter parameter, and they outperform most of the well-known pulses reported in the literature, since they present lower error probability, smaller maximum distortion and wider eye-diagram.
Demography, Risk Factors, and Clinical and Microbiological Features of Microbial Keratitis at a Tertiary Eye Hospital in Nepal

Background Infective keratitis is the most common corneal pathology in developing countries. Updated knowledge is needed for its control and proper management. Methodology All cases of presumed microbial keratitis that presented in an 18-month period from October 2013 to March 2015 were enrolled. Data collected were demographic profile, risk factors, clinical features, and organisms isolated and their sensitivities. Results A total of 602 cases of microbial keratitis were enrolled. Mean age of subjects (598 patients) was 47.9 years with 53.8% male. 64.1% worked in agriculture. 38.3% gave history of trauma followed by history of herpetic eye diseases (17.9%) and topical steroid use (14.2%). A total of 473 who were referred came at an average of 21.5 days of symptoms. 14.9% (n=90) of cases were either perforated or impending to perforate at presentation. 69.6% had infiltrate in the visual axis. A total of 516 (85.7%) underwent diagnostic corneal culture. A total of 256 (49.6%) yielded a positive result. Pure bacterial growth was seen in 111 (43.4%), pure fungal growth in 138 (53.9%), and mixed microbial growth was present in 7 (2.7%) cases. Out of 121 bacterial isolates, 95.0% were Gram positive. Streptococcus pneumoniae (45.5%, n=55) was the most common bacterial isolate followed by Staphylococcus aureus (20.6%, n=25). Out of 145 fungal isolates, Aspergillus and Fusarium species were found in equal numbers (n=41, 28.3% each). Over 85% of Gram-positive organisms isolated in the study were sensitive to vancomycin, cefazolin, moxifloxacin, and gatifloxacin. Over 80% of Gram-negative organisms were sensitive to gentamicin, tobramycin, and amikacin. Conclusion Microbial keratitis and associated risk factors occurring in farmers implies a lack of awareness and prevention programs. Delay in reaching tertiary care is resulting in complicated cases. Training of local health workers for prophylaxis, updated guidelines for treating keratitis, and timely referral to higher centers are all important in a chain to decrease the incidence of microbial keratitis.
Non-thermal filaments from the tidal destruction of clouds in the Galactic centre

Synchrotron-emitting, nonthermal filaments (NTFs) have been observed near the Galactic center for nearly four decades, yet their physical origin remains unclear. Here we investigate the possibility that NTFs are produced by the destruction of molecular clouds by the gravitational potential of the Galactic center. We show that this model predicts the formation of a filamentary structure with length on the order of tens to hundreds of pc, a highly ordered magnetic field along the axis of the filament, and conditions conducive to magnetic reconnection that result in particle acceleration. This model therefore yields the observed magnetic properties of NTFs and a population of relativistic electrons, without the need to appeal to a dipolar, $\sim$ mG, Galactic magnetic field. As the clouds can be both completely or partially disrupted, this model provides a means of establishing the connection between filamentary structures and molecular clouds that is observed in some, but not all, cases.
Detection of the LMC-induced sloshing of the Galactic halo

A wealth of recent studies have shown that the LMC is likely massive, with a halo mass >1011 M⊙. One consequence of having such a nearby and massive neighbour is that the inner Milky Way is expected to be accelerated with respect to our Galaxy’s outskirts (beyond ∼30 kpc). In this work, we compile a sample of ∼500 stars with radial velocities in the distant stellar halo, rGC > 50 kpc, to test this hypothesis. These stars span a large fraction of the sky and thus give a global view of the stellar halo. We find that stars in the Southern hemisphere are on average blueshifted, while stars in the North are redshifted, consistent with the expected, mostly downwards acceleration of the inner halo due to the LMC. We compare these results with simulations and find the signal is consistent with the infall of a 1.5 × 1011 M⊙ LMC. We cross-match our stellar sample with Gaia DR2 and find that the mean proper motions are not yet precise enough to discern the LMC’s effect. Our results show that the Milky Way is significantly out of equilibrium and that the LMC has a substantial effect on our Galaxy.
High Tongue Position is a Risk Factor for Upper Airway Concentric Collapse in Obstructive Sleep Apnea: Observation Through Sleep Endoscopy

Purpose Identification of upper airway (UA) obstruction based on pharyngeal factors is important for obstructive sleep apnea (OSA) evaluation. This study is to assess the association between UA collapse characteristics and Friedman tongue position (FTP) in patients with OSA through drug-induced sleep endoscopy (DISE). Patients and Methods Retrospective study in individuals with OSA who were intolerant to continuous positive airway pressure (CPAP) treatment, submitted to DISE between June 1, 2013, and July 31, 2017. All subjects were classified as having an FTP grade of I to IV, and the velum, oropharynx, tongue base, epiglottis (VOTE) classification was used to analyze the DISE findings. UA collapse characteristics by DISE and FTP grading were compared between groups. The associations between specific DISE findings and FTP were analyzed. Results In total, 205 patients were assessed. A positive and significant correlation was identified between the presence of retropalatal complete concentric collapse (CCC) and FTP grade, according to the following distributions: I, 17.4%; II, 22.9%; III, 33.7%; and IV, 48.7% (P = 0.014). A logistic regression model revealed that CCC was associated with FTP grade IV. After adjusting for age, sex, body mass index (BMI), and tonsil size (TS), the grade IV individuals had a 4.4-fold higher risk of having CCC than grade I individuals (P = 0.026). Multiple collapse sites and palatopharyngeal or combined (palatopharyngeal and hypopharyngeal) collapse were more prevalent in grade IV individuals. Conclusion OSA patients intolerant to CPAP have a strong positive correlation between the FTP grade and presence of retropalatal CCC. FTP grade IV is an independent risk factor for velum-CCC, controlling for sex, age, BMI, and TS grade.
VEGF TrapR1R2 Suspended in the Semifluorinated Alkane F6H8 Inhibits Inflammatory Corneal Hem- and Lymphangiogenesis

Purpose Semifluorinated alkanes (SFAs) are used at the ocular surface as lubricants or vehicles for drugs. The purpose of this study was to test the effect of vascular endothelial growth factor (VEGF) TrapR1R2 suspended in the SFA perfluorohexyloctane (Trap/F6H8) on corneal neovascularization. Methods Suture placement was used to induce inflammatory corneal neovascularization in mice. Treatment groups were: Trap/F6H8, VEGF TrapR1R2 as aqueous formulation dissolved in phosphate buffer (Trap), F6H8, and phosphate buffer (controls). Eye drops were applied 3×/daily for 2 weeks. Afterward, corneas were stained with CD31 and LYVE-1 to analyze corneal hem- and lymphangiogenesis. To investigate the effect of on inflammatory cell recruitment, corneal CD45+ cells were quantified. In addition, epithelial wound closure after debridement was assessed by corneal fluorescein staining. Results Trap/F6H8 was as effective as Trap in inhibiting corneal hemangiogenesis and lymphangiogenesis after 2 weeks of treatment. After 3 days of treatment, Trap/F6H8 was even more effective than Trap in inhibiting corneal hemangiogenesis. Both treatment groups (Trap/F6H8 and Trap) significantly reduced corneal CD45+ cell recruitment. Epithelial closure after debridement was unaffected by Trap/F6H8 or Trap. Conclusions In this study, we demonstrate that F6H8 is a potential carrier for VEGF TrapR1R2 to topically treat corneal neovascularization. Our findings might open new treatment avenues for local anti-angiogenic therapy at the cornea, as F6H8 is already approved for the usage at the ocular surface. Translational Relevance With this study we show for the first time that SFAs can serve as carriers for anti-angiogenic drugs at the ocular surface.