Miracle-dz/UniFAR-FTUs huggingface dataset:
Natural product-induced oxidative stress-synergistic anti-tumor effects of chemotherapeutic agents

Reactive oxygen species are closely related to tumor development. In recent years, reactive oxygen species has become a hot spot in tumor therapy, and many natural substances in nature contain compound components with anti-tumor effects. However, there is a lack of discussion on the synergistic anti-tumor effects of natural products in combination with chemotherapeutic drugs through reactive oxygen species. The terms “natural products”, “reactive oxygen species”, “anti-tumor”, and “chemotherapy” were used to identify the synergistic effects of natural products. We conducted a systematic literature search in PubMed and Web of Science databases for relevant research articles and reviews published in recent years. We systematically summarized the studies related to anti-tumor active ingredients in natural compounds in the field of reactive oxygen species in recent years. A total of 77 relevant literatures were included. Among them, 45 literatures containing various natural products such as terpenoids, flavonoids, alkaloids, etc. exert anti-tumor effects by regulating reactive oxygen species levels, and 32 literatures regarding adjunctive role of natural products in anti-tumor therapy. In this study, we found that natural products exert anti-tumor effects by elevating reactive oxygen species levels. It provides strong theoretical support for future clinical studies.
Features of small scale enterpreneur and access to credit in Nigeria: a microanalysis

This study investigates determinants of access of small-scale enterprises to credit in Nigeria. Three hundred and fifty respondents were selected using stratified sampling techniques. Descriptive statistics such as percentages, frequency distribution and logit regression were employed in analyzing the data. The results showed sex, age, marital status, family size, capital assets, interest rate, and level of education and other dwelling characteristics of small-scale enterprises influence access to use of credit from credit institutions. Key works: Small-scale enterprises, Access to Credit, Credit Markets, Nigeria.
Seamless Crime Scene Reconstruction in Mixed Reality for Investigation Training: A Design and Evaluation Study

Investigation training at the real crime scene is a critical component of forensic science education. However, bringing young investigators to real crime scenes is costly and faces significant challenges. Mixed reality (MR) is one of the most evolving technologies that provides unlimited possibilities for practical activities in the education sector. This article aims to propose and evaluate a novel design of an MR system using Microsoft HoloLens 2.0 that is tailored to work in a spatial 3-D-scanned and reconstructed crime scene. The system was designed to be a cost-effective experience that helps young Kuwaiti police officers enhance their investigation skills. The proposed system has been evaluated through system usability, user interaction, and performance metrics quantitatively via 44 young police officers and qualitatively using the think-aloud protocols via a group of experts. Both groups showed positive levels of usability, user interaction, and overall satisfaction, with minimal negative feedback. Based on the positive feedback, the system will be taken into the commercialization stage in the future. Despite the high cost of the MR device, experts stated that the system is needed as an essential tool for crime scene education and investigation practices.
The Relationship Between Export and Technological Specialisation Profiles Across EU Countries and Regions and the Identification of Development Potentials

The aim of this study is to analyse the development of new industrial specialisations and the process of export diversification both at the country and the regional level for the EU countries over time. It examines to what extent these processes show path dependent properties, whether persistent development trajectories can be shifted in order to avoid structural traps and what role related and unrelated diversification play for the economic performance of regions. Overall, the results of this report and its policy implications underscore that Smart Specialisation policies require a smooth coordination of a larger set of diverse policy measures that take into account both the local context and all the involved players rather than a perfect setup of single policies. In particular, the educational system, specialisation patterns in research and innovation, and foreign direct investments play a key role in diversification processes and should be a constitutive element of Smart Specialisation policies.
Cell Therapy in the Treatment of Coronary Heart Disease

Heart failure is a leading cause of death in patients who have suffered a myocardial infarction. Despite the timely use of modern reperfusion therapies such as thrombolysis, surgical revascularization and balloon angioplasty, they are sometimes unable to prevent the development of significant areas of myocardial damage and subsequent heart failure. Research efforts have focused on developing strategies to improve the functional status of myocardial injury areas. Consequently, the restoration of cardiac function using cell therapy is an exciting prospect. This review describes the characteristics of various cell types relevant to cellular cardiomyoplasty and presents findings from experimental and clinical studies investigating cell therapy for coronary heart disease. Cell delivery methods, optimal dosage and potential treatment mechanisms are discussed.
The influence of bed roughness on the dynamics of gravity currents

To date the influence of bed roughness onl the propagation and dynamics of gravity currents has been largely neglected. A new physical modelling dataset has been compiled, which details the fundamental affects of several bed roughnesses on lock-release gravity currents. Five bed configurations were chosen encompassing 'grain' and 'form' type elements at a range of spacings. 1%, 5% and 10% initial density excesses were studied and the effect of removing the buoyant ambient fluid between the elements examined. Observations due to changing the current depth relative to the element height were also made. Ultrasonic Doppler velocimetry profiling (UDVP) and video capture techniques were used to analyse stream wise and vertical velocity structures and the affects on the front speed and distance travelled by the current. A 10 depth-averaged model solves modified 2-layer shallow water equations using the method of characteristics to obtain temporal velocity and depth evolution for a current under the influence of a general roughness quantity. 2D and 3D depth-resolved CFD simulations use the commercial software FLUENT to solve the RANS equations and transport of a scalar for the dense current with the RNG k - € turbulence model. The CFD predictions were well validated by the new experimental dataset and provide supplementary predictions of concentration, lateral motion and activity in the vicinity of the roughness elements. Comparison of 20 and 30 models resulted in the conclusion that the 3D model is vital for accurate simulation of internal dynamics of gravity current propagation over beam type bed roughness. In general general, the distance that the front travels decreases with any bed roughness present.This reduction increases with element spacing. The stream wise mean velocity profiles show a reduced velocity maximum further from the bed. Decreased entrainment results from breakdown of larger billows. Also observed is a thicker current, a rounder profile and a shorter, diluted head. Areas of increased vertical motion within the current. associated with decreased horizontal motion are observed, indicative of ejections of ambient fluid from between the elements. The presence of this fluid is found to contribute to ~ 50% of the current retardation. There are also similarities with the effects of bed roughness in open channel and pipe flows, most notably there is a critical element spacing (11'/ kr ~ 7) where the effects of roughness are greatest (where w is element spacing and kr is element height). The experimental and numerical results demonstrate that the application of existing models that rely on experimental validation with smooth beds to situations where a rough boundary is present may lead to significant errors.
A Process‐Based Model to Track Water Pollutant Generation at High Resolution and Its Pathway to Discharge

The estimation of water pollutant loads is of crucial importance as it decides data inputs for both subsequent water quality models and watershed pollutant mitigation strategy. However, the generation of water pollutant loads at high resolution and the life‐cycle pathway of them from sources, through pipelines and wastewater treatment plants, finally to recipient water bodies remain unclear. This study aims to establish a process‐based Water Pollutant Loads Tracking model and applies it to a rapidly urbanizing watershed in Taihu Lake Basin, China at the resolution of 5 m × 5 m in 2017, whose terrain is flat, slowly lowing from west to east. Results show that, of 261.55 tons of the total phosphorus (TP) generation, 71.28% is collected, and 64.32% is treated, with only 26.46% discharged to the water bodies and 1.25% to the target ones. The spatial hotspots of TP generation are mainly concentrated in residential and industrial areas. Direct discharges from point sources and nonpoint runoffs, especially in rainy seasons, are recognized as the main challenges for local water pollution control. The main innovation of this study is to quantify the generation of water pollutant loads at high resolution and to trace the subsequent pathway to collection and discharge, and then to identify the potential substantial gap between generation and discharge, demonstrating the efficacy and broader applicability of this model.
Emotional intelligence and work engagement: The Moderating effect of work-related psychological impact due to the COVID-19 pandemic

Although emotional intelligence has been linked to employee engagement in the private sector, there is very little research regarding public sector employees. This study explores how emotional intelligence influences work engagement with work-related psychological impact acting as a moderator. The study adopts the cognitive–motivational–relational theory of emotions, which has a minimal research focus in developing countries. Using stratified random sampling, a self-designed questionnaire and interviews, data was gathered from public servants and analysed. The results showed that Emotional Intelligence (emotional management, emotional evaluation and emotional control) positively influences work engagement. Also, emotional management had the highest (positive) impact on work engagement among the three variables. Additionally, it was discovered that the psychological needs at the workplace negatively moderated emotions having positive effect on work engagement. Therefore, employees are encouraged to utilise their emotions to positively influence work engagement and reduce work-related psychological issues and reduce its negative effect on work engagement. Further, work-related psychological impact moderated the relationship between emotional intelligence and work engagement in this study. Theoretically, the use of the cognitive–motivational–relational in developing countries with regard to public sector frontline employees during and after the COVID-19 pandemic is unique.
Toward variances for X-11 seasonal adjustments

We develop an approach to estimating variances for X-11 seasonal adjustments that recognizes the effects of sampling error and errors from forecast extension. In our approach, seasonal adjustment error in the central values of a sufficiently long series results only from the effect of the X-11 filtering on the sampling errors. Towards either end of the series, we also recognize the contribution to seasonal adjustment error from forecast and backcast errors. We extend the approach to produce variances of errors in X-11 trend estimates, and to recognize error in estimation of regression coefficients used to model, e.g., calendar effects. In empirical results, the contribution of sampling error often dominated the seasonal adjustment variances. Trend estimate variances, however, showed large increases at the ends of series due to the effects of fore/backcast error. Nonstationarities in the sampling errors produced striking patterns in the seasonal adjustment and trend estimate variances.
Endoscopic third ventriculostomy versus ventriculoperitoneal shunt in patients of hydrocephalus in eastern India: A prospective observational study

Background: Hydrocephalus is a disorder of cerebrospinal fluid (CSF) physiology, resulting in an abnormal enlargement of the ventricles due to excessive accumulation of CSF. Although neurosurgical treatment has evolved over time with ventriculoperitoneal shunt (VPS) as the standard of care, procedure-related complications and poor long-term cognitive and motor milestone outcomes are still considerable, justifying the need for safer alternatives. Endoscopic third ventriculostomy (ETV) has emerged as a promising prospect especially in non-communicating hydrocephalus (NCH). Aims and Objectives: To compare the beneficial effects of ETV versus ventriculoperitoneal shunt in patients of NCH. Materials and Methods: The present prospective study was conducted at the Department of Neurosurgery, Bangur Institute of Neurosciences, IPGMER and SSKM Hospital, Kolkata from July 2021 to December 2022 among 60 patients admitted with NCH. Out of 60 patients; 30 patients underwent ETV and the remaining 30 patients VP shunting. All included patients had their history taken and relevant clinical and radiological examination done pre-operatively. They were discharged on the third post-operative day or later depending on their clinical condition and recovery. Results: Aqueductal stenosis was the most common etiology for NCH in both the groups. Post-intervention, complications and reoperation rate were reported more in VP group as compared to ETV group. Overall 3 subjects died, out of which 2 belonged to VP group and 1 to ETV group. Success was found in 70% and 86.67% of the subjects in VP and ETV group respectively. Conclusion: In patients with non-communicating or obstructive hydrocephalus, ETV was reported to be superior to VPS in terms of reoperation and complication rate at 4th, 12th, and 24th weeks after the treatment.
Family-centered approach in Early Childhood Intervention of a vulnerable population from an Ecuadorian rural context

Introduction Studies about the implementation of the Family Centered Practices approach in Early Childhood Intervention refer as outcomes that have an impact on the Quality of Family Life, on children’s development, and also on family empowerment. In Ecuador, despite an absence of Early Childhood Intervention policies and programs, a university has developed training in Family Centered Practices for graduate students. A formative component is to implement a Routines Based Model with families of children with disabilities. The aim of the study is to analyze the impact on the Family Quality of Life, children’s development and self-perceived competence of families after the Routines Based Model has been implemented in their natural environment. Method Eight families from a rural area and their children with disabilities were included in the study. The Family Quality of Life Scale-Early Childhood Intervention and the Screening of the Battelle Developmental Inventory were applied at the beginning and end of the process. A qualitative interview established the family perspective upon the outcomes in their family and their children. Results There is evidence of a significant increase in the families’ Quality of Life and in the children’s development at the end of the process. At the interview the families declared themselves more competent to understand and contribute to the development of their children. Discussion The results provide knowledge of the implementation of a Routine Based Model in vulnerable contexts. Also contributes in the understanding of the family perspective on the outcomes and perceived benefits for the children and the family itself as a measure of quality of the intervention and training. Implications of the results for initial and ongoing training of early care professionals with vulnerable populations are discussed.
FAKTOR-FAKTOR YANG BERHUBUNGAN DENGAN BUANG AIR BESAR DI JAMBAN DI DESA GUNUNGSARI KECAMATAN PULOSARI KABUPATEN PEMALANG

Behavior of using toilet is the most effective, simple, and easy to prevent several kind of disease such as diarrhea, cholera. Pemalang cases of diarrhea in the year 2012 as many as 55.014 unreported cases. The number of cases has increased compared to the year 2011 as many as 11.982 cases. Based on data obtained in the village Gunungsari Pulosari the District Pemalang district that the head of the family who defecation as many as 224 households.Extension healthy latrines as a solution by the Health Department program through methods STBM (Community Based Total Sanitation ) first pillar is Stop Babs. The purpose of this study is to determine the factors associated with bowel movements in the toilet. This type of research is quantitative , using analytic study that examined the relationship between independent variables and the dependent variable, with cross sectional design, study population consisted of 100 head of households. Data analyzed is using univariate and bivariate, analytic bivariate test Chi- Square ( µ = 0.05). Significance is determined if the p-value less than 0.05. The findings showed that of the 100 , 57 % aged ≥ 42 years, 77 % had a job, 53 % have an income < UMR, 61 % had good knowledge, 73 % have a good attitude, 57 % have good manners, 64 % availability of the category of good, 65 % have a good family support, 69 % had good support health workers, 74 % have a good peer support, 57 % have a good support community leaders. Of the Chi - Square test showed that the variable ) job ( p - value = 0.002 ), the level of knowledge ( p - value = 0.002 ) , attitude ( p - value = 0.019) , the availability of means ( p- value = 0.000 ) , family support ( p - value = 0.005) , the support of community leaders ( p - value = 0.040 ) have a relationship significantly with defecation in the toilet. It is suggested to local governments to coordinate with relevant agencies to engage with the community try to get people to defecate in toilet.
Clinical Application of ImmunoPET Targeting Checkpoint Inhibitors

Simple Summary Cancer treatment with immune checkpoint inhibitors (ICIs) has significantly impacted patients’ management and outcomes. To better assess the benefit of ICIs and reduce the risk of treatment-induced side-effects, new predictive biomarkers have been investigated. From a molecular imaging point of view, several PET tracers have been developed to examine the immune checkpoint (IC) status and the characteristics of the tumor microenvironment (TME). Herein, we present the most relevant data on ImmunoPET-targeting ICs and tumor-infiltrating lymphocytes (TILs), with a main focus on the latest developments in clinical molecular imaging studies of solid tumors. Abstract In the last decade, monoclonal antibodies (mAbs) targeting CTLA-4, PD-1, or PD-L1 have been developed and immune checkpoint inhibitors (ICIs) have become the main approach in cancer immunotherapy. However, not all patients benefit from ICI therapy and some are at risk of developing treatment-induced side-effects. These aspects, in parallel with the imaging challenges related to response assessments during immunotherapy, have driven scientific research to the discovery of new predictive biomarkers to individualize patients who could benefit from ICIs. In this context, molecular imaging using PET (positron emission tomography), which allows for whole-body tumor visualization, may be a promising non-invasive method for the determination of patients’ sensitivity to antibody drugs. Several PET tracers, diverse from 2-[18F]FDG (or 2-Deoxy-2-[18F]fluoroglucose), have been developed to image immune checkpoints (ICs) or key elements of the immune system, although most of them are still in preclinical phases. Herein, we present the current state of the ImmunoPET-targeting of IC proteins with mAbs and antibody fragments, with a main focus on the latest developments in clinical molecular imaging studies of solid tumors. Moreover, given the relevance of the immune system and of tumor-infiltrating lymphocytes in particular in the prediction of the benefit of ICIs, we dedicate a portion of this review to ImmunoPET-targeting T cells.
Distribution and Pathogenicity of Fusarium Species Associated with Soybean Root Rot in Northeast China

Fusarium root rot is an increasingly severe problem in soybean cultivation. Although several Fusarium species have been reported to infect soybean roots in Heilongjiang province, their frequency and aggressiveness have not been systematically quantified in the region. This study aimed to investigate the diversity and distribution of Fusarium species that cause soybean root rot in Heilongjiang province over two years. A total of 485 isolates belonging to nine Fusarium species were identified, with F. oxysporum and F. solani being the most prevalent. Pot experiments were conducted to examine the relative aggressiveness of different Fusarium species on soybean roots, revealing that F. oxysporum and F. solani were the most aggressive pathogens, causing the most severe root rot symptoms. The study also assessed the susceptibility of different soybean cultivars to Fusarium root rot caused by F. oxysporum and F. solani. The results indicated that the soybean cultivar DN51 exhibited the most resistance to both pathogens, indicating that it may possess genetic traits that make it less susceptible to Fusarium root rot. These findings provide valuable insights into the diversity and distribution of Fusarium species that cause soybean root rot and could facilitate the development of effective management strategies for this disease.
Internal Tide Observations from the Australian North West Shelf in Summer 1995

Abstract Observations are presented of the internal tide over the continental shelf and slope from a cross section on the Australian North West Shelf. Data collected from moored instruments and repeated profile measurements during the summer months of 1995 show an energetic, large amplitude, shoreward propagating semidiurnal internal tide. Multiple generation sites are suggested, coinciding with near-critical bottom slopes. In water less than approximately 200 m deep, the vertical structure of the internal tide is predominantly a first vertical mode, whereas in deeper water over the slope the vertical structure is more complicated with currents and vertical displacements intensified in the lower part of the water column. The internal tide is largely confined to a region approximately 100 km wide, from water depths between 70 and 1000 m. Strong generation and dissipation of the internal tide energy is observed over this region and there is evidence that the dissipated energy impacts on the vertical mixing .