Miracle-dz/UniFAR-FTUs huggingface dataset:
Clusters of Dementia Literacy: Implications from a Survey of Older Adults

Clinicians and scientists suggest that up to 40% of dementia cases are potentially preventable. Data on awareness of dementia risk and protective factor among older adults can inform and facilitate designing educational interventions to prevent dementia. We aimed to quantify awareness of dementia risk and protective factors using a telephone survey. The modified Lifestyle for Brain Health scale was used to assess dementia risk and prevention knowledge. A representative sample of 1,005 older adults, mean age 64.02 (standard deviation + 1.4; range: 50–74 years) completed the survey (77% response rate). Under representation of non-European ethnicities was noted. Participants Respondents were all New Zealanders, more women (n=518, 51.5%), mostly European (n=921, 91.6%) and well educated (n=347, 34.5%, university or post-graduate degree). Only 6/14 modifiable risk or protective factors for dementia were adequately identified. Three clusters of dementia literacy were identified: psychosocial, medical and activities. These findings support personalizing dementia prevention efforts via targeted educational packages.
Pengaruh angka harapan hidup, rata-rata lama sekolah dan pengeluaran perkapita terhadap tingkat kemiskinan pada Kabupaten /Kota di Provinsi Jambi

This study aims to analyze the development of life expectancy, the average length of schooling, expenditure per capita, and poverty level in districts/cities in Jambi Province, as well as analyze the effect of life expectancy, the average length of schooling, and expenditure per capita on poverty levels. The analytical method used is panel data regression. The results of this study indicate that. After the Chow and Hausmant test, the best model is the Fixed effect. Partially, the analysis results of the variable life expectancy and expenditure per capita significantly impact the poverty level. At the same time, the average length of school does not have a significant effect. Simultaneously, life expectancy, the average schooling size, and per capita expenditure significantly impact poverty levels in districts/cities in Jambi province Keywords: Poverty, Life expectancy, Length of schooling, Expenditure per capita
Mixed-integer Programming for Centralized Coordination of Connected and Automated Vehicles in Dynamic Environment

Connected and automated vehicles (CAVs) have shown the potential to improve safety, increase throughput, and optimize energy efficiency and emissions in complicated traffic scenarios. This paper presents a mixed-integer linear programming (MILP) method for scheduling and coordination of CAVs in a highly dynamic environment that consists of multiple human-driven vehicles and multiple conflict zones, such as merging points and intersections. The proposed approach ensures safety, high throughput and energy efficiency by solving a centralized high-level decision making problem. The solution provides a feasible and optimal time schedule through road segments and conflict zones for the automated vehicles, by using information from the position, velocity, and destination of the manual vehicles, which cannot be directly controlled. The performance and computational load of the proposed method are assessed in closed-loop simulations on an illustrative scenario. Despite MILP having combinatorial complexity, the proposed formulation appears feasible for real-time implementation, e.g., in mobile edge computers (MECs).
Physical Therapy Following Arthroscopic Rotator Cuff Repair with Graft Augmentation: A Case Report with Magnetic Resonance Imaging

Objective: If non-surgical treatment fails, arthroscopic rotator cuff repair (ARCR) is recommended, and ARCR considers graft augmentation in consideration of size, direction, and re-tear. It is reported to have potential benefits by improving the healing rate as it can fill the gaps that have been left behind. The purpose of this study is to investigate the effect of structural changes observed after ARCR on muscle action through magnetic resonance imaging and to investigate the effect of appropriate physical therapy required for graft augmentation in the general ARCR rehabilitation protocol. Case presentation: A 47-year-old male hospitalized for postoperative rehabilitation following ARCR participated in a 5-week physical therapy intervention. The postoperative day was 6 months, but due to shooting pain and shoulder dysfunction,and the movement of the shoulder was compensatory motion, not normal motion. Physical agents, manual therapy, and supervised exercise for 110 minutes per session were performed 3 times a week, and pain intensity, range of motion, function, and strength were evaluated. Results: As a result of the study, the patient showed positive improvement in pain intensity, range of motion, function, and strength. In addition, normal scapulohumeral rhythm movement was observed. Conclusions: According to the results of this case, appropriate physical therapy according to the compensatory motion shown in the structural changes after ARCR can positively improve the pain intensity, range of motion, function, and strength of ARCR patients.
Early Adolescents’ Social Goals in Peer Conflict Situations: A Mixed Methods Study

Identification of goals is a key social-cognitive process that guides whether adolescents engage in aggressive or nonviolent behavior during social conflicts. This study investigated early adolescents’ goals in response to hypothetical social conflict situations involving close friends and peers. Participants (n = 160; Mage = 12.7, 53% female) were 7th graders from two urban and one rural middle school. On average, participants identified 2.5 goals for each situation. Qualitative analysis using a grounded theory approach identified nine themes representing the goals generated by participants: instrumental-control, relationship maintenance, maintain image and reputation/self-defense, conflict avoidance, seek more information, revenge, tension reduction, moral, and stay out of trouble. Quantitative analysis indicated that female participants identified more goals than male participants, but there were few differences in their types of goals. There were few differences across school sites. The findings highlight the variety of social goals specific to the developmental period of early adolescence.
Improving the Storage Quality of Eggplants (Solanum Aethiopicum L.) Fruit using Aloe Vera Gel Coating

Aloe vera gel has been investigated as possible edible coating to help improve the storage life of fruits after harvest. The study sought to investigate the effect Aloe vera gel coating with or without citric acid pretreatment on the quality of eggplant fruits during low temperature storage and in shelf life. Briefly, eggplants were coated with Aloe vera gel (some fruits were pretreated with citrate prior to the coating) and the changes in physicochemical quality of the fruit measured during storage at 10 °C. After 14 days, however, some fruits were transferred for storage at room temperature until day 18. Coating with Aloe vera decreased moisture loss, and consequently, decreased weight loss and loss of firmness of the fruit. The coating did help maintain the phenolic content, ascorbate levels and antioxidant capacity of the fruit. Pre-treating the fruit with citrate did not improve quality, showing that Aloe vera gel can be applied alone to enhance the storage quality of eggplant fruit. Results obtained from this study shows that Aloe vera gel coating can be useful in extending the postharvest storage life and maintaining the quality of eggplant fruits during low temperature storage.
Problematic Mobile Phone Use Increases with the Fear of Missing Out Among College Students: The Effects of Self-Control, Perceived Social Support and Future Orientation

Introduction Mobile phones bring much convenience to college students’ lives, but they also cause problems. Few studies have explored the effect of the fear of missing out (FoMO) on problematic mobile phone use among college students. This study tested the mediating effect of self-control in the relationship between FoMO and problematic mobile phone use. It also explored the moderating roles of perceived social support and future orientation in the relationship between these variables. Methods A cross-sectional design was used in this study. Materials include the Fear of Missing Out Scale, Perceived Social Support Scale, Self-control Scale (Chinese version), Mobile Phone Addiction Index, and Consideration of Future Consequences Scale. Of 3606 participants, 3189 completed the questionnaire. SPSS 21 was used to analyze the mediation and moderation effects. Results The results showed that problematic mobile phone use was positively predicted by FoMO. The relationship between FoMO and problematic mobile phone use was partially mediated by self-control. When the scores of perceived social support and future orientation were high, the negative effect of FoMO on problematic mobile phone use was reduced. Conclusion The negative effect of FoMO on problematic mobile phone use through self-control was moderated by perceived social support and future orientation.
E-ZAKAT: AN APPROACH FOR ZAKAT MANAGEMENT TO ERADICATE POVERTY

This paper has shown an online-based zakat management system named E-ZAKAT. Zakat is one of the main foundational goals of the world’s second-largest religion, Islam. So, it has indisputable importance for a country as well as the world economy and poverty eradication. During the COVID-19 pandemic, people have become habituated with the online system due to unavoidable situations, such as education and commodity market has now turned into online systems. However, an online base zakat management system for both donors and seekers has not prevailed widely. Here in this proposed system, the donor can calculate, donate their zakat, and the seeker can apply to receive it. Instead of providing cash, business or agricultural help is planned to ensure the economic stability of a low-income family. For this purpose, the expectant can claim support for green farming, agricultural equipment, or money to start a small business after ensuring the required verification and qualification steps. The proposed dynamic web application E-ZAKAT will provide an easier and hassle-free system for zakat donors and seekers with an attractive design. As a result, proper utilization of our system could provide a positive impact to change our society as well as our world.
The Effect of Elections on Capital Expenditure and Social Assistance Expenditure

The purpose of this study is to determine differences in the allocation of capital expenditure and social assistance expenditure before and during the local elections. This study uses Wilcoxon test as non parametric test. The results show that the proportion of capital expenditure and social assistance expenditure at the time of the election is not greater than the proportion of capital expenditure and social assistance expenditure at the prior to the election. But, there is not difference the proportion of capital expenditure at the time of the election is as well as at the prior to the election.
NAFLD and vitamin D: Evidence for intersection of microRNA-regulated pathways

Abstract Non-alcoholic fatty liver disease (NAFLD) is now the most common cause of chronic liver disease, worldwide. The molecular pathogenesis of NAFLD is complex, involving numerous signalling molecules, including microRNAs (miRNAs). Dysregulation of miRNA expression is associated with hepatic inflammation, fibrosis and hepatocellular carcinoma. Although miRNAs are also critical to the cellular response to vitamin D, mediating regulation of the vitamin D receptor and vitamin D’s anti-cancer effects, the role of vitamin-D-regulated miRNAs in NAFLD pathogenesis has been relatively unexplored. Therefore, this review aims to critically assess the evidence for a potential subset of miRNAs that are both dysregulated in NAFLD and modulated by vitamin D. Comprehensive review of eighty-nine human studies identified twenty-five miRNAs found dysregulated in more than one NAFLD study. In contrast, only seventeen studies, including a protocol for a trial in NAFLD, had examined miRNAs in relation to vitamin D status, response to supplementation, or vitamin D in the context of the liver. This paper summarises these data and reviews the biological roles of six miRNAs (miR-21, miR-30, miR-34, miR-122, miR-146, miR-200) found dysregulated in multiple independent NAFLD studies. While modulation of miRNAs by vitamin D has been understudied, integration of the data suggests seven vitamin-D-modulated miRNAs (miR-27, miR-125, miR-155, miR-192, miR-223, miR-375, miR-378) potentially relevant to NAFLD pathogenesis. Our summary tables provide a significant resource to underpin future hypothesis-driven research, and we conclude that the measurement of serum and hepatic miRNAs in response to vitamin D supplementation in larger trials is warranted.
Readiness and Stakeholders Influence for Halal Logistics Practices Implementation towards Supply Chain Performance

Halal industry is expanding worldwide, and it requires strong supply chain management to enhance halal business efficiency and preserve credibility through halal logistics process. However, studies on halal logistics remain limited and isolated. Thus, this study aimed to understand the impact of stakeholders on halal logistics practices among Malaysian halal-certified manufacturers. The primary objectives of this study are to examine the underlying dimensions of halal logistics practices, investigate the level of halal logistics practices, investigate the extent of stakeholders' influence on halal logistics practices, and explore the relationship of halal logistics practices towards supply chain performance. Based on the data collected through a questionnaires survey from 270 managers from halal-certified manufacturers, SPSS and SmartPLS were used to test the hypotheses. The findings of the study indicated that operational dimensions are the most practiced dimensions of halal logistics amongst firms. Meanwhile, competitors, government, NGOs, community media and society, and customers significantly influence the adoption of halal logistics practices. Importantly, halal logistics practices are positively related to supply chain performance. This study has extended the feasibility of stakeholder theory in the sense of halal logistics to the scope and comprehensiveness of stakeholders. The outcome of this study provides important implications to both academics and practitioners, particularly in the halal industry.
Knowledge Transfer through Computer-based Systems in Manufacturing Networks: A Study on Albanian Plants

This study shows a general view about knowledge transfer between manufacturing plants in developing countries like Albania, which are part of multinational companies’ network (MCN). Part of this goal is the study of computer-based systems from conference calls and intranets to more advanced ones like data warehouses, management information systems (MIS) and executive information systems (EIS), as enablers of knowledge flow and absorptive capacity. The paper examines four case studies based on semi-structured interviews, where the data collected highlight a good coverage of computer-based systems in function of knowledge sharing. In half of the cases, this is done internally in the plant and not over the network of plants. We propose to upgrade where possible the systems used in a distributed way to have data and information connections across the network. In some cases, emerge barriers such as lack of time, lack of tolerance for errors, or the need for assistance. Conclusions show that staff training related to computer-based systems in the optics of knowledge enablers is important for the companies, while the incentives are not considered as a key factor for knowledge transfer. Received: 15 July 2021 / Accepted: 23 September 2021 / Published: 3 January 2022
Generation and functional characterization of a multigene-modified NK101 cell line exerting diverse mechanisms of antitumor action

ABSTRACT Clonal cell line-based, multigene-modified, off-the-shelf NK cell therapeutics are emerging as the new frontier of adoptive cellular immunotherapy. Here, we utilized a newly established NK cell line, NK101, as a backbone to derive multifaceted killer cells armored with various antitumor modalities through repeated cycles of genetic modification and clonal selection. First, NK101 cells were transduced with a tricistronic lentiviral vector expressing CD7, CD28, and cytosine deaminase (CD). The resulting cell line demonstrated enhanced cytotoxicity against B7+ tumors and exerted bystander killing effects on neighboring tumor cells upon 5-FC treatment. Second, engineered NK101 cells were again transduced with a bicistronic vector expressing membrane-bound interleukin-15 (mbIL-15) and dominant negative TGFβ type II receptor (DNTβRII). Ectopic expression of mbIL-15 resulted in further augmentation of lytic activities against all tested target cells by inducing upregulation of multiple activating receptors, while that of DNTβRII allowed the cells to maintain heightened cytotoxicity in the presence of TGFβ. Finally, dual-transduced NK101 cells were modified to express chimeric antigen receptors (CARs) targeting either a solid tumor antigen (EpCAM) or a hematologic tumor antigen (FLT3). The final engineered products not only demonstrated antigen-specific killing activities in vitro but also exerted strong tumor-inhibitory effects in preclinical models of metastatic solid tumor and hematologic malignancy. Notably, combined treatment with 5-FC further enhanced antitumor efficacy of engineered NK101 in the solid tumor model. Our results demonstrate successful generation of multigene-modified NK101 cell therapeutics exerting diverse mechanisms of antitumor action – activation receptor-mediated innate killing, antigen-specific killing, and bystander effect-mediated killing.
Comparison of visual acuity measured by ETDRS based smart phone applications I sight pro and Peek acuity versus traditional Snellen\\\'s chart visual acuity in children 6-14 years in a tertiary care institute in India

Covid-19 pandemic has led to children missing schools due to which eye care screening activities at schools have taken a backseat. To mitigate this home based visual acuity estimation smartphone applications are increasingly being used for the purpose of tele-ophthalmology purposes, although with no validation of the same. We aim to fulfil this lacunae. Current study was a cross sectional analysis on 286 eyes of 148 children aged between 6years to 14years attending our OPD from April 2021 to June 2021, with non-acute ocular symptomatology. Snellen’s distant visual acuity was compared against the visual acuity recorded by smart phone based Isight pro app and Peek acuity smart phone app. Statistical analysis was performed by Bland Altmann analysis by using SPSS version 21 and p<0.05 was taken as the level of significance. The mean differences between the smartphone-based test Isight pro and the Snellen’s chart and the smartphone-based test Peek acuity and Snellen’s acuity data were 0.06 (95%CI, 0.04–0.08) and 0.07 (95%CI,0.05–0.09) logMAR, respectively. Time taken to test visual acuity by Snellen’s chart was approximately 118.2±21.38 seconds, whereas with Isight pro and Peek acuity smart phone apps the time for testing was approximately 92±15.88 seconds and 94.03±19.73 seconds respectively. P<0.05. The mean visual acuity was comparable with Snellen’s chart and ETDRS based smart phone apps like Isight pro and Peek acuity. The mean time to assess visual acuity was slightly more in Snellen’s acuity than with smart phone based apps. Inability to access eye care services through screening activities in schools has been mitigated effectively by using these smart phone apps. Hence these smart phone apps can be effectively used in tele-ophthalmologic practice and screening activities in these COVID-19 pandemic times.
Research challenges and future directions towards medical data processing

ABSTRACT Data in the healthcare industry and machine learning techniques is useful to analyse a huge amount of data to identify the hidden patterns in the disease, to give personalised treatment for the patient and also used to predict the disease. The main intent of this paper is to plan for a systematic review on medical storage systems, noise removal techniques for medical images and multi-disease prediction using artificial intelligence. This paper conducts a algorithmic contributions used for medical storage systems, noise removal in medical images and multi-disease prediction that are analysed. Moreover, the performance metrics measured in various contributions adopted tools, and different datasets utilised for solving those problems are surveyed. Finally, a strong research gaps and challenges that will pave the way for creating a room for future research perspective are explored. The suitable research gap is focused with the existing limitations in traditional medical storage systems, noise removal methods and multi-disease prediction models that could motivate the researchers to focus on developing new models. Thus, with a strong integration of biomedical and healthcare data, modern healthcare organisations can possibly revolutionise the medical therapies and personalised medicine
Effect of Dimensionality on The Electronic Properties of SnSe: A Density Functional Theory Study

This study investigated the structural and electronic properties of bulk, bilayer, and monolayer SnSe using the density functional theory (DFT) method. We succeeded in calculating the bandgap and identifying accurately the transformation of the band structure from bulk to monolayer systems using generalized gradient approximation. An increase in the lattice parameter a and a decrease in the lattice parameter b were observed when the bulk dimensions were reduced to a monolayer. The reduction of van der Waals interactions when the dimensions of a system are reduced is the main factor that causes changes in lattice parameters. The indirect bandgap of bulk SnSe (0.56 eV, 0.3∆→0.7Σ) becomes wider in the monolayer system (0.94 eV, 0.2∆→0.8Σ). Bandgap widening is predicted due to the emergence of the quantum confinement effect in low-dimensional systems. Furthermore, we found the formation of a quasi-degenerate minimum conduction band in the monolayer SnSe. With the formation of these bands, we predict the monolayer SnSe will have better thermoelectric properties than the bulk or bilayer system. This study provides an in-depth understanding of the electronic structure of SnSe and its correlation to thermoelectric properties.