Miracle-dz/UniFAR-FTUs huggingface dataset:
The Delta-Configured Modular Multilevel Converter

The modular multilevel converter (MMC) has become an attractive option for dc/ac conversion in many power system applications, in particular, for HVDC transmission. Due to its parallel arrangement of phase legs, the MMC is known to be a wye-configured architecture. In this paper, the equivalent delta formulation of the conventional wye architecture is introduced. The delta-configured MMC, enabled by series-stacking phase legs, is an alternative realization to the wye-configured MMC and has significantly different operating characteristics. The introduction of the delta MMC enables greater flexibility in converter voltage/current scaling for a given set of submodules, and may be an appealing option for dc/ac applications requiring a power tapoff from a high-voltage dc rail. The single-ended and differential delta topologies are derived, with the latter seen as the preferred topology due to its reduced energy-storage requirements. The principle of operation of the differential delta-configured MMC is described in detail. A dynamic controller is developed that regulates grid power injections while suppressing unwanted circulating ac currents. Comprehensive simulation results validate the differential delta MMC operation and the proposed control scheme.
A Comprehensive Study of the L1551 IRS 5 Binary System

We model the Class I source L1551 IRS 5, adopting a flattened infalling envelope surrounding a binary disk system and a circumbinary disk. With our composite model, we calculate self-consistently the spectral energy distribution of each component of the L1551 IRS 5 system, using additional constraints from recent observations by ISO, the water ice feature from observations with SpeX, the SCUBA extended spatial brightness distribution at submillimeter wavelengths, and the VLA spatial intensity distributions at 7 mm of the binary disks. We analyze the sensitivity of our results to the various parameters involved. Our results show that a flattened-envelope collapse model is required to explain simultaneously the large-scale fluxes and the water ice and silicate features. On the other hand, we find that the circumstellar disks are optically thick in the millimeter range and are inclined so that their outer parts hide the emission along the line of sight from their inner parts. We also find that these disks have lower mass accretion rates than the infall rate of the envelope.
Predicting passenger flow using different influence factors for Taipei MRT system

Nowadays more and more people in the big city rely on public transportations while they go to work or school. MRT (Mass Rapid Transit) is one of the most modern transportations in Taipei. It is a great traffic tool to relieve the pressure of rush hours. According to the statistics, each day there will be over one million of passengers taking the MRT in Taipei. In this paper, we will be predicting MRT passenger flow with random forest, by using different factors collected from the Taipei Main station as input for training. The result shows that some of the influenced factors are important to affect the prediction of the passenger flow.
Illumination Invariant Facial Pose Classification

this paper, we compared the performance of various combinations of edge operators and linear subspace methods to determine the best combination for pose classification. To evaluate the performance, we have carried out experiments on CMU-PIE database which contains images with wide variation in illumination and pose. We found that the performance of pose classification depends on the choice of edge operator and linear subspace method. The best classification accuracy is obtained with Prewitt edge operator and Eigenfeature regularization method. In order to handle illumination variation, we used adaptive histogram equalization as a preprocessing step resulting into significant improvement in performance except for Roberts operator. General Terms Pattern Recognition, Classification. KeywordsClassification, Edge detection, Linear Subspace Methods.
Text string detection for the first grade visually impaired pupils “reading mandarin textbooks”

A text string detection method is proposed to help visually impaired first grade pupils read mandarin textbooks. To detect the actual text in view, and recognizing that a textbook is normally held open with both hands, the proposed method sequentially detects seeing a textbook, and then detects skin colors, index fingers and thumbs, text string region, and text strings. Experimental results show that the proposed method performs better than conventional two frame differencing methods. Furthermore, the proposed method reduces time complexity and has 98.5% text string total detection rate for the experimental videos.
Improving the Power Density of the ZVS-SVM Controlled Three-Phase Boost PFC Converter

The compound active clamping three-phase boost rectifier proposed by authors has a clamp branch composed of an active switch, a resonant inductor and a clamping capacitor. With a novel zero voltage switching space vector modulation (ZVS-SVM) method, the rectifier can realize ZVS operation for all switching devices and effectively suppress the reverse recovery process of the bridge leg switch anti-parallel diode. In addition, both the main switches and the auxiliary switch have the same and fixed switching frequency. In this paper, the soft switching condition of the ZVS-SVM controlled three-phase boost PFC is analyzed. The relationship between the switching loss of the converter and the circuit resonant parameters is studied. The EMI noise between hard switching and soft switching converter is also investigated. The results are verified by a 20 kW prototype.
Preventive zinc supplementation for children, and the effect of additional iron: a systematic review and meta-analysis

Objective Zinc deficiency is widespread, and preventive supplementation may have benefits in young children. Effects for children over 5 years of age, and effects when coadministered with other micronutrients are uncertain. These are obstacles to scale-up. This review seeks to determine if preventive supplementation reduces mortality and morbidity for children aged 6 months to 12 years. Design Systematic review conducted with the Cochrane Developmental, Psychosocial and Learning Problems Group. Two reviewers independently assessed studies. Meta-analyses were performed for mortality, illness and side effects. Data sources We searched multiple databases, including CENTRAL and MEDLINE in January 2013. Authors were contacted for missing information. Eligibility criteria for selecting studies Randomised trials of preventive zinc supplementation. Hospitalised children and children with chronic diseases were excluded. Results 80 randomised trials with 205 401 participants were included. There was a small but non-significant effect on all-cause mortality (risk ratio (RR) 0.95 (95% CI 0.86 to 1.05)). Supplementation may reduce incidence of all-cause diarrhoea (RR 0.87 (0.85 to 0.89)), but there was evidence of reporting bias. There was no evidence of an effect of incidence or prevalence of respiratory infections or malaria. There was moderate quality evidence of a very small effect on linear growth (standardised mean difference 0.09 (0.06 to 0.13)) and an increase in vomiting (RR 1.29 (1.14 to 1.46)). There was no evidence of an effect on iron status. Comparing zinc with and without iron cosupplementation and direct comparisons of zinc plus iron versus zinc administered alone favoured cointervention for some outcomes and zinc alone for other outcomes. Effects may be larger for children over 1 year of age, but most differences were not significant. Conclusions Benefits of preventive zinc supplementation may outweigh any potentially adverse effects in areas where risk of zinc deficiency is high. Further research should determine optimal intervention characteristics and delivery strategies.
Frequency and amplitude dependences of molding accuracy in ultrasonic nanoimprint technology

We use neither a heater nor ultraviolet lights, and are researching and developing an ultrasonic nanoimprint as a new nano-patterning technology. In our ultrasonic nanoimprint technology, ultrasonic vibration is not used as a heat generator instead of the heater. A mold is connected with an ultrasonic generator, and mold patterns are pushed down and pulled up at a high speed into a thermoplastic. Frictional heat is generated by ultrasonic vibration between mold patterns and thermoplastic patterns formed by an initial contact force. However, because frictional heat occurs locally, the whole mold is not heated. Therefore, a molding material can be comprehensively processed at room temperature. A magnetostriction actuator was built into our ultrasonic nanoimprint system as an ultrasonic generator, and the frequency and amplitude can be changed between dc–10 kHz and 0–4 µm, respectively. First, the ultrasonic nanoimprint was experimented by using this system on polyethylene terephthalate (PET, Tg = 69 °C), whose the glass transition temperature (Tg) is comparatively low in engineering plastics, and it was ascertained that the most suitable elastic material for this technique was an ethyl urethane rubber. In addition, we used a changeable frequency of the magnetostriction actuator, and nano-patterns in an electroformed-Ni mold were transferred to a 0.5 mm thick sheet of PET, polymethylmethacrylate (PMMA) and polycarbonate (PC), which are typical engineering plastics, under variable molding conditions. The frequency and amplitude dependence of ultrasonic vibration to the molding accuracy were investigated by measuring depth and width of imprinted patterns. As a result, regardless of the molding material, the imprinted depth was changed drastically when the frequency exceeded 5 kHz. On the other hand, when the amplitude of ultrasonic vibration grew, the imprinted depth gradually deepened. Influence of the frequency and amplitude of ultrasonic vibration was not observed on the width of imprinted patterns. Moreover, the imprinted depth deepened as the Tg of the molding material lowered, and a progressive change according to conditions of ultrasonic vibration also became remarkable. Therefore, it seems that impressing ultrasonic vibration with a high frequency and large amplitude promotes thermal deformation and improves the molding accuracy in the ultrasonic nanoimprint technology.
Efficient mouse transgenesis using Gateway-compatible ROSA26 locus targeting vectors and F1 hybrid ES cells

The ability to rapidly and efficiently generate reliable Cre/loxP conditional transgenic mice would greatly complement global high-throughput gene targeting initiatives aimed at identifying gene function in the mouse. We report here the generation of Cre/loxP conditional ROSA26-targeted ES cells within 3–4 weeks by using Gateway® cloning to build the target vectors. The cDNA of the gene of interest can be expressed either directly by the ROSA26 promoter providing a moderate level of expression or by a CAGG promoter placed in the ROSA26 locus providing higher transgene expression. Utilization of F1 hybrid ES cells with exceptional developmental potential allows the production of germ line transmitting, fully or highly ES cell-derived mice by aggregation of cells with diploid embryos. The presented streamlined procedures accelerate the examination of phenotypical consequences of transgene expression. It also provides a unique tool for comparing the biological activity of polymorphic or splice variants of a gene, or products of different genes functioning in the same or parallel pathways in an overlapping manner.
IGBT spice - An experimentally verified model with parameters extraction by device nondestructive measurements

he insulated-gate bipolar transistor (IGBT) was introduced into the family of power devices to overcome high onstate loss while maintaining the simple gate drive requirements of power metal-oxide semicdonductor field-effect transistors (MOSFETs). IGBTs combine both bipolar and MOSFET structures and possesses the best features of both device types. Because the IGBT has a low-power gate drive requirement, a high-current density capability, and a high switching speed, it is preferable to other devices in many high power applications. A schematic representation of a single cell for an n-channel IGBT is shown in Figure 1(a), and its simplified equivalent circuit is shown in (b) [1]–[3].
Physico-chemical and micromechanical analysis of the interface in a poly(phenylene sulfide)/glass fiber composite : A microbond study

The glass flber/PPS composite has excellent thermal and chemical properties. The main disadvantage of the composite is its poor mechanical resistance to impact. To improve this property, the fibers were coated with a new type of sizing. The required characteristics for this sizing is to create strong interactions between the PPS matrix and the glass fiber surface. The ability of the sizings to improve the glass/PPS adhesion has been assessed by the microbond technique. An inconvenience of this technique is the difficulty in defining a parameter that is characteristic of the interfacial adhesion. The objective of this publication is to demonstrate that a plastic flow of the PPS matrix around the fiber leads to a uniform shear strength. The adhesion between these two materials can therefore be obtained by the mean interfacial shear strength.
Ligation Independent Cloning of Polycistronic, Genetically Modified, HuMAb4D5-8 F (ab') 2, in Bacterial Plasmid

In recent years, recombinant monoclonal antibodies and their derivatives have emerged as important targeted therapy agents. Monoclonal antibodies are extremely difficult to produce. So, the cost of production is very high and many people cannot afford these drugs. In this regard, choosing inexpensive and easy ways to manipulate production systems such as bacterial hosts to reduce the cost of manufacturing these critical components are considered as vital step for developmental issues in recombinant expression systems. We, therefore, attempted to generate a polycistronic construct of anti HER-2 F(ab')2 fragment antibody for insertion in an expression bacterial plasmid. Also some modifications were made in the hinge region to express antibody F(ab')2 fragment in its authentic form preventing from multiple varieties of disulfide bond formation. Finally, synthesized construct was cloned in pET-32 Ek/LIC vector without using restriction enzyme digestion or ligation reactions. The results of this study showed that modified F(ab')2 fragment was simply and successfully inserted in Escherichia coli (E.coli) using the Ligation Independent Cloning technology.
Propagation of embryonic stem cells in stirred suspension without serum

Embryonic stem cells (ESCs) with their unlimited capacity for self‐renewal and ability to differentiate along multiple cell lineages are a superb starting material for biotechnology applications and cellular therapies. However, realization of the potential of ESCs requires the development of scalable systems for their production in large quantities and in a regulated manner. Here, we describe a methodology for the expansion of mouse ESCs (mESCs) as pluripotent aggregates in a stirred suspension bioreactor and in medium without serum. Initially, the culture of feeder cell‐independent mESCs in dishes was adapted to serum‐free conditions. Also, we explored whether spinner flasks equipped with a triangle‐shaped impeller and baffles support the culture of mESC aggregates. Serum‐free culture in these vessels resulted in an almost 20‐fold increase in the live mESC concentration over 4 days without significant loss of cell viability. Even after consecutive passages, mESCs retained high expression of pluripotency markers Oct3/4, Rex1 and SSEA‐1. More importantly, when differentiation was induced these cells adopted fates of all three germ layers namely neuroectoderm, cardiac mesoderm and definitive endoderm. These findings demonstrate that stem cells can be propagated under serum‐free conditions in a scalable stirred‐suspension culture without loss of their pluripotency.
Characterization of a type IV collagen major cell binding site with affinity to the alpha 1 beta 1 and the alpha 2 beta 1 integrins

The aim of this investigation was to identify the domains of type IV collagen participating in cell binding and the cell surface receptor involved. A major cell binding site was found in the trimeric cyanogen bromide-derived fragment CB3, located 100 nm away from the NH2 terminus of the molecule, in which the triple-helical conformation is stabilized by interchain disulfide bridges. Cell attachment assays with type IV collagen and CB3 revealed comparable cell binding activities. Antibodies against CB3 inhibited attachment on fragment CB3 completely and on type IV collagen to 80%. The ability to bind cells was strictly conformation dependent. Four trypsin derived fragments of CB3 allowed a closer investigation of the binding site. The smallest, fully active triple-helical fragment was (150)3-amino acid residues long. It contained segments of 27 and 37 residues, respectively, at the NH2 and COOH terminus, which proved to be essential for cell binding. By affinity chromatography on Sepharose-immobilized CB3, two receptor molecules of the integrin family, alpha 1 beta 1 and alpha 2 beta 1, were isolated. Their subunits were identified by sequencing the NH2 termini or by immunoblotting. The availability of fragment CB3 will allow for a more in-depth study of the molecular interaction of a short, well defined triple-helical ligand with collagen receptors alpha 1 beta 1 and alpha 2 beta 1.
Towards Alzheimer's disease classification through transfer learning

Detection of Alzheimer's Disease (AD) from neuroimaging data such as MRI through machine learning have been a subject of intense research in recent years. Recent success of deep learning in computer vision have progressed such research further. However, common limitations with such algorithms are reliance on a large number of training images, and requirement of careful optimization of the architecture of deep networks. In this paper, we attempt solving these issues with transfer learning, where state-of-the-art architectures such as VGG and Inception are initialized with pre-trained weights from large benchmark datasets consisting of natural images, and the fully-connected layer is re-trained with only a small number of MRI images. We employ image entropy to select the most informative slices for training. Through experimentation on the OASIS MRI dataset, we show that with training size almost 10 times smaller than the state-of-the-art, we reach comparable or even better performance than current deep-learning based methods.
Band-like arrangement of taste-like sensory cells at the gastric groove: evidence for paracrine communication

The discovery of taste-related elements within the gastrointestinal tract has led to a growing interest in the mechanisms and physiological significance of chemosensory monitoring of chymus composition. Previous work suggests that brush cells located in the “gastric groove,” which parallels the “limiting ridge,” a structure in rodents that divides the fundus from the corpus, are candidate sensory cells. A novel sectioning technique revealed that these cells are arranged in a palisade-like manner forming a band which borders the whole length of the corpus epithelium. Using transgenic PLCβ2 promoter-GFP mice and specific antibodies, we have demonstrated that most of these cells express gustducin, PLCβ2, and TRPM5; typical signaling proteins of gustatory sensory “type II” cells. These molecular features strongly suggest that the cells may be capable of sensing nutrient or non-nutrient constituents of the ingested food. Since there is no evidence that brush cells are endocrine cells, attempts were made to explore how such putative chemosensory cells might transmit the information to “effector” cells. It was found that most of the cells express the neuronal nitric oxide synthase (NOS) suggesting some paracrine interaction with adjacent cells. Moreover, they also express choline acetyltransferase (ChAT) as well as the vesicular protein SNAP25, indicating the potential for cholinergic transmission, possibly with subjacent enteric nerve fibers.
Conformational Analysis of the Androgen Receptor Amino-terminal Domain Involved in Transactivation

The androgen receptor (AR) is a member of the nuclear receptor superfamily. Sequences within the large amino-terminal domain of the receptor have been shown to be important for transactivation and protein-protein interactions; however, little is known about the structure and folding of this region. In the present study we show that a 344-amino acid polypeptide representing the main determinants for transactivation has the propensity to form α-helical structure and that mutations which disrupt putative helical regions alter conformation. Folding of the AR was observed in the presence of the helix-stabilizing solvent trifluoroethanol and the natural osmolyte trimethylamine N-oxide (TMAO). TMAO resulted in the movement of two tryptophan residues to a less solvent-exposed environment and the formation of secondary/tertiary structure resistant to protease cleavage. Critically, binding to the RAP74 subunit of the general transcription factor TFIIF resulted in extensive protease resistance, consistent with induced folding of the receptor transactivation domain. These data indicate that this region of the AR is structurally flexible and folds into a stable conformation upon interactions with a component of the general transcription machinery.
Mobility support using SIP

Enabling mobility in IP networks is an important issue for making use of the many light-weight devices appearing at the market. The IP mobility support being standardized in the IETF uses tunnelling of IP packets from a Home Agent to a Foreign Agent to make the mobility transparent to the higher layer. There are a number of problems associated with Mobile IP, such as triangular routing, each host needing a home IP address, tunnelling management, etc. In this paper, we propose to use mobility support in the application layer protocol SIP where applicable, in order to support real-time communication in a more efficient way.