Miracle-dz/UniFAR-FTUs huggingface dataset:
Alternative Social Media and the Complexities of a More Participatory Culture: A View From Scuttlebutt

Recent research has highlighted the emergence of “alternative social media” platforms. Developed by open source communities with non-commercial goals, these platforms can offer more expansive participatory cultures than corporate platforms. However, such platforms also involve new kinds of participatory challenges, such as requiring high technological literacy. This article examines the complexity of enacting participatory cultures by drawing on an ethnographic study of Scuttlebutt, a decentralized social media platform being developed by an open source community. This examination focuses on three key features of participatory culture as enacted on Scuttlebutt: varying modes and sites of participation; reflexivity about who is participating and how; and an evaluation of limits to participation. It also considers the challenges that arise from Scuttlebutt’s approach and how these highlight the profound difficulty of trying to enact fuller models of participatory culture. From these findings, we argue that Scuttlebutt provides an important example of the experimentation that alternative social media platforms are conducting around open, democratic modes of socio-technical organizing, and note that this experimentation raises important questions about how we conceptualize participation and the future of social media.
Heterometallic Europium(III)–Lutetium(III) Terephthalates as Bright Luminescent Antenna MOFs

A new series of luminescent heterometallic europium(III)–lutetium(III) terephthalate metal–organic frameworks, namely (EuxLu1−x)2bdc3·nH2O, was synthesized using a direct reaction in a water solution. At the Eu3+ concentration of 1–40 at %, the MOFs were formed as a binary mixture of the (EuxLu1−x)2bdc3 and (EuxLu1−x)2bdc3·4H2O crystalline phases, where the Ln2bdc3·4H2O crystalline phase was enriched by europium(III) ions. At an Eu3+ concentration of more than 40 at %, only one crystalline phase was formed: (EuxLu1−x)2bdc3·4H2O. All MOFs containing Eu3+ exhibited sensitization of bright Eu3+-centered luminescence upon the 280 nm excitation into a 1ππ* excited state of the terephthalate ion. The fine structure of the emission spectra of Eu3+ 5D0-7FJ (J = 0–4) significantly depended on the Eu3+ concentration. The luminescence quantum yield of Eu3+ was significantly larger for Eu-Lu terephthalates containing a low concentration of Eu3+ due to the absence of Eu-Eu energy migration and the presence of the Ln2bdc3 crystalline phase with a significantly smaller nonradiative decay rate compared to the Ln2bdc3·4H2O.
Design and Analysis of Distributed Optimal Controller for Identical Multiagent Systems

This paper studies the optimal distributed control design problem for both continuous‐time and discrete‐time systems. We consider an identical decoupled dynamical system and a coupled performance index which is described through the Laplacian matrix. It is showed that the optimal feedback gain matrix corresponds to a complete undirected graph for the Laplacian matrix in the cost function. We aim to get the distributed controllers that only use the information of its state and the states of its neighbors. The existence conditions of the optimal distributed control for special cost function are given and the asymptotic stability of the system is discussed. Examples are given to show the efficiency of the proposed results.
Genome-Wide Analysis of the SPL Gene Family and Expression Analysis during Flowering Induction in Prunus × yedoensis ‘Somei-yoshino’

SQUAMOSA Promoter-Binding Protein-Like (SPL) genes encode plant-specific transcription factors which bind to the SQUAMOSA promoter of the MADS-box genes to regulate its expression. It plays important regulatory roles in floral induction and development, fertility, light signals and hormonal transduction, and stress response in plants. In this study, 32 PySPL genes with complete SBP (squamosa promoter binding protein) conserved domain were identified from the genome of Prunus × yedoensis ‘Somei-yoshino’ and analyzed by bioinformatics. 32 PySPLs were distributed on 13 chromosomes, encoding 32 PySPL proteins with different physical and chemical properties. The phylogenetic tree constructed with Arabidopsis thaliana and Oryza sativa can be divided into 10 subtribes, indicating PySPLs of different clusters have different biological functions. The conserved motif prediction showed that the number and distribution of motifs on each PySPL is varied. The gene structure analysis revealed that PySPLs harbored exons ranging from 2 to 10. The predictive analysis of acting elements showed that the promoter of PySPLs contain a large number of light-responsive elements, as well as response elements related to hormone response, growth and development and stress response. The analysis of the PySPLs expressions in flower induction and flower organs based on qRT-PCR showed that PySPL06/22 may be the key genes of flower development, PySPL01/06 and PySPL22 may play a role in the development of sepal and pistil, respectively. The results provide a foundation for the study of SPL transcription factors of Prunus × yedoensis ‘Somei-yoshino’ and provide more reference information of the function of SPL gene in flowering.
Light-responsive transcription factor PpWRKY44 induces anthocyanin accumulation by regulating PpMYB10 expression in pear

Abstract Anthocyanins are a valuable source of antioxidants in the human diet and contribute to fruit coloration. In red-skinned pears, anthocyanin biosynthesis can be induced by light, in which the MYB–bHLH–WDR complex plays a critically important role in transcriptional regulation. However, knowledge of WRKY-mediated transcriptional regulation of light-induced anthocyanin biosynthesis is scarce in red pears. This work identified and functionally characterized a light-inducing WRKY transcription factor, PpWRKY44, in pear. Functional analysis based on overexpressed pear calli showed that PpWRKY44 promoted anthocyanin accumulation. Also, transiently overexpressed PpWRKY44 in pear leaves and fruit peels significantly enhanced the accumulation of anthocyanin, whereas silencing PpWRKY44 in pear fruit peels impaired induction of the accumulation of anthocyanin by light. By chromatin immunoprecipitation and electrophoretic mobility shift assay coupled to a quantitative polymerase chain reaction, we found that PpWRKY44 bound in vivo and in vitro to the PpMYB10 promoter, revealing it as a direct downstream target gene. Moreover, PpWRKY44 was activated by PpBBX18, a light signal transduction pathway component. Our results explained the mechanism mediating the impacts of PpWRKY44 on the transcriptional regulation of anthocyanin accumulation, with potential implications for fine-tuning the fruit peel coloration triggered by light in red pears.
HUBUNGAN ANTARA ESCAPISM DENGAN KECENDERUNGAN KECANDUAN GAME ONLINE PADA ANGGOTA KOMUNITAS ESPORT X SEMARANG

Penelitian ini ditujukan untuk mengetahui hubungan antara escapism dengan kecenderungan kecanduan game online pada anggota komunitas esport X di Semarang. Escapism adalah dorongan dari dalam diri individu untuk melarikan diri dari tekanan ataupun tuntutan yang berasal dari dunia nyata seperti pekerjaan ataupun keluarga dengan cara melakukan kegiatan lain diluar kegiatan yang ingin dihindari. Kecenderungan kecanduan game online adalah perilaku bermain game online pada individu yangwew masih dapat mengontrol perilakunya tersebut, namun perilaku tersebut tetap dapat menyebabkan reaksi psikologis berupa stres, perasaan tidak nyaman ataupun perilaku bermain game online yang berlebihan dan berdampak buruk terhadap orang-orang di sekitarnya. Populasi dalam penelitian ini berjumlah 171 anggota mahasiswa komunitas esport X dengan sampel penelitian berjumlah 74 mahasiswa. Komunitas esport X adalah wadah bagi mahasiswa di Universitas X yang bertujuan untuk mengembangkan kreativitas dan menghadapi disrupsi industri 4.0 dengan standar kompetensi teknologi tinggi dalam konteks industri game online. Teknik sampling pada penelitian ini adalah dengan convenience sampling. Alat ukur yang digunakan adalah Skala Escapism (20 aitem, α = 0,92) dan Skala Kecenderungan Kecanduan Game Online (37 aitem α = 0,94). Analisis data menggunakan analisis regresi sederhana dengan hasil koefisien korelasi sebesar 0,737. Hasil penelitian menunjukkan terdapat hubungan positif antara escapism dengan kecenderungan kecanduan game online pada anggota komunitas esport X. Escapism memberikan sumbangan efektif sebesar 54,3% terhadap kecenderungan kecanduan game online pada anggota komunitas esport X dan 45,7% adalah pengaruh dari faktor-faktor lainnya.
The Effect of Psychological Safety on Innovation Behavior: A Meta-Analysis

This meta-analysis examines the relationship between psychological safety and innovation behavior and explores potential moderators that may moderate the relationship: cultural context and team type. A total of 94 independent samples of 85 articles meet the inclusion criteria (N=19180) through literature screening. The results of this study indicate that psychological safety has a significant effect on employee innovation behavior (r=0.299) and team innovation behavior (r=0.435); in addition, we found that cultural background moderate the relationship between psychological safety and employee innovation behavior; and team type moderate the relationship between psychological safety and team innovation behavior. In summary of the results, this meta-analysis highlights the impact of psychological safety on different contexts of innovation behavior and also provides a reference for future psychological safety research.
Exploring Impacts of a Nutrition-Focused Massive Open Online Course

The nutrition education landscape is changing due to advances in technology. Massive Open Online Courses (MOOCs) are an example of new education opportunities, made possible by advances in online learning environments. This research aimed to evaluate a nutrition-focused MOOC, applying Kirkpatrick’s theoretical model of learning, to comprehensively describe learners’ reactions, knowledge and behaviours. A mixed-methods approach explored learners’ experiences of participating in a global nutrition MOOC. Quantitative survey data, using descriptive statistics, measured pre-course nutrition knowledge, post-course satisfaction and learning, and changes to fruit/vegetable intake. Qualitative data from discussion forums and semi-structured interviews were thematically analysed and explored participant experiences and perceived impacts on dietary behaviours and nutrition knowledge. All results were mapped to Kirkpatrick’s model. Surveys measuring perceived knowledge, satisfaction, and fruit and vegetable intake were completed by 4941, 1003 and 1090 participants, respectively. Overall reactions to the course were positive. Perceived vegetable intake increased for 62% of participants. Twelve interviews and six hundred and forty-seven forum comments were analysed, identifying eight themes highlighting changes to knowledge and dietary behaviours, and the importance of peer-to-peer learning. All results mapped to Levels 1–3 of Kirkpatrick’s model. MOOCs can be an effective platform to communicate evidence-based nutrition information to large, global audiences.
eif4ebp3l—A New Affector of Zebrafish Angiogenesis and Heart Regeneration?

The eukaryotic initiation factor 4E binding protein (4E-BP) family is involved in translational control of cell proliferation and pro-angiogenic factors. The zebrafish eukaryotic initiation factor 4E binding protein 3 like (eif4ebp3l) is a member of the 4E-BPs and responsible for activity-dependent myofibrillogenesis, but whether it affects cardiomyocyte (CM) proliferation or heart regeneration is unclear. We examined eif4ebp3l during zebrafish vascular development and heart regeneration post cryoinjury in adult zebrafish. Using morpholino injections we induced silencing of eif4ebp3l in zebrafish embryos, which led to increased angiogenesis at 94 h post fertilization (hpf). For investigation of eif4ebp3l in cardiac regeneration, zebrafish hearts were subjected to cryoinjury. Regenerating hearts were analyzed at different time points post-cryoinjury for expression of eif4ebp3l by in situ hybridization and showed strongly decreased eif4ebp3l expression in the injured area. We established a transgenic zebrafish strain, which overexpressed eif4ebp3l under the control of a heat-shock dependent promotor. Overexpression of eif4ebp3l during zebrafish heart regeneration caused only macroscopically a reduced amount of fibrin at the site of injury. Overall, these findings demonstrate that silencing of eif4ebp3l has pro-angiogenic properties in zebrafish vascular development and when eif4ebp3l is overexpressed, fibrin deposition tends to be altered in zebrafish cardiac regeneration after cryoinjury.
Galactic hail: the origin of the high-velocity cloud complex C

High-velocity clouds consist of cold gas that appears to be raining down from the halo to the disc of the Milky Way. Over the past 50 years, two competing scenarios have attributed their origin either to gas accretion from outside the Galaxy or to circulation of gas from the Galactic disc powered by supernova feedback (galactic fountain). Here, we show that both mechanisms are simultaneously at work. We use a new galactic fountain model combined with high-resolution hydrodynamical simulations. We focus on the prototypical cloud complex C and show that it was produced by an explosion that occurred in the Cygnus-Outer spiral arm about 150 Myr ago. The ejected material has triggered the condensation of a large portion of the circumgalactic medium and caused its subsequent accretion on to the disc. This fountain-driven cooling of the lower Galactic corona provides the low-metallicity gas required by chemical evolution models of the Milky Way's disc.
The effects of a thermogenic supplement on metabolic and hemodynamic variables and subjective mood states

ABSTRACT Background Thermogenic supplements are widely used in the general population to support attempted fat loss; however, the efficacy and safety of these supplements are questioned. Purpose To determine whether a thermogenic supplement affects metabolic rate, hemodynamic responses, and mood states. Methods In a randomized double-blind crossover design, 23 females (22.2 ± 3.5 years; 164.8 ± 6.4 cm; 73.5 ± 6.9 kg) who were moderate caffeine consumers (<150 mg/day) reported to the lab after a 12 h fast for baseline assessments of resting energy expenditure (REE) via indirect calorimetry, heart rate (HR), blood pressure (SBP and DBP), blood variables, and hunger, satiety, and mood states. Thereafter, subjects ingested the assigned treatment (active treatment containing caffeine, micronutrients, and phytochemicals [TR] or placebo [PL]). All variables were reassessed at 30-, 60-, 120-, and 180 min post-ingestion. Subjects repeated the same protocol with ingestion of the opposite treatment on a separate day. All data were analyzed using a 2 × 5 ANOVA with repeated measures and significance was accepted a priori at p < 0.05. Results In the TR group, mean increases in REE of 121 to 166 kcal/d were observed at 30-, 60-, and 180 min post-ingestion (p < 0.01 for all). PL group mean decreases in REE of 72 to 91 kcal/day were observed at 60-, 120-, and 180 min (p < 0.05 for all). Respiratory quotient decreased at 120 and 180 min in both treatments. Slight increases in SBP of 3–4 mmHg were observed at 30, 120, and 180 min (p < 0.05 for all) post-ingestion of TR, while no effects were observed for DBP. Observed increases in SBP were within normal blood pressure ranges. TR decreased subjective fatigue with no other significant changes in mood states. Glycerol was maintained in TR, while there was a decrease at 30, 60, and 180 min (p < 0.05 for all) post-ingestion of PLA. Free fatty acids increased in TR at 60 and 180 min (p < 0.05) post-ingestion as well as a significant difference between treatments at 30 min post-ingestion indicating greater circulating free fatty acids levels in TR vs. PL (p < 0.01). Conclusion These findings indicate that ingestion of a specific thermogenic supplement formulation produces a sustained increase in metabolic rate and caloric expenditure and reduces fatigue over 3 h without producing adverse hemodynamic responses.
Radiomics Models Based on Magnetic Resonance Imaging for Prediction of the Response to Bortezomib-Based Therapy in Patients with Multiple Myeloma

Purpose To identify significant radiomics features based on MRI and establish effective models for predicting the response to bortezomib-based regimens. Materials and Methods In total, 95 MM patients treated with bortezomib-based therapy were enrolled, including 77 with bortezomib, cyclophosphamide, and dexamethasone (BCD) and 18 with bortezomib, lenalidomide, and dexamethasone (VRD). Based on T1-weighted imaging (T1WI) and T2-weighted imaging with fat suppression (T2WI-fs), radiomics features were extracted and then selected. The random forest (RF), k-nearest neighbor, support vector machine, logistic regression, decision tree, and Bayes models were built using the selected features. The predictive power of six models for response to BCD and VRD regimens were evaluated. The correlation between the selected features and progression-free survival (PFS) was also analyzed. Results Four wavelet features were correlated with BCD treatment response. The six models all showed predictive power for BCD regimen (AUC: 0.84-0.896 in the training set, 0.801-0.885 in the validation set), and RF performed relatively better than others. Nevertheless, all the BCD-based models were incapable of predicting the VRD treatment response. The wavelet-HLH_firstorder_kurtosis was also associated with PFS (log-rank P = 0.019). Conclusion The four wavelet features were valuable biomarkers for predicting the response to BCD regimen. The six models based on these features showed predictive power, and RF was the best. One wavelet feature was also a survival-related biomarker. MRI-based radiomics had the potential to guide clinicians in MM management.
Loss of CD47 alters CD8+ T cell activation in vitro and immunodynamics in mice

ABSTRACT CD47 has established roles in the immune system for regulating macrophage phagocytosis and lymphocyte activation, with growing evidence of its cell-intrinsic regulatory roles in natural killer and CD8+ T cells. CD47 limits antigen-dependent cytotoxic activities of human and murine CD8+ T cells, but its role in T cell activation kinetics remains unclear. Using in vitro and in vivo models, we show here that CD47 differentially regulates CD8+ T cell responses to short- versus long-term activation. Although CD47 was not required for T cell development in mice and early activation in vitro, short-term stimuli elevated pathogen-reactive gene expression and enhanced proliferation and the effector phenotypes of Cd47-deficient relative to Cd47-sufficient CD8+ T cells. In contrast, persistent TCR stimulation limited the effector phenotypes of Cd47 −/− CD8+ T cells and enhanced their apoptosis signature. CD8+ T cell expansion and activation in vivo induced by acute lymphocytic choriomeningitis virus (LCMV) infection did not differ in the absence of CD47. However, the frequency and effector phenotypes of Cd47−/− CD8+ T cells were constrained in chronic LCMV-infected as well as in mice bearing B16 melanoma tumors. Therefore, CD47 regulates CD8+ T cell activation, proliferation, and fitness in a context-dependent manner.
Age-specific oviposition behavior of Trichogramma brassicae on Ephestia kuehniella under laboratory conditions

Biological characteristics especially oviposition behavior of parasitoids are one of the most important factors to determine their efficiency to suppress a pest population. In this study, age-specific oviposition pattern, parasitism rate, hatch rate, and sex ratio of Trichogramma brassicae on Ephestia kuehniella were evaluated at temperature of 25±1ºC, 70±5% relative humidity and a 16 h light: 8 h dark photoperiod. The results showed that younger T. brassicae (1st-4th days) moved throughout the cardboard and often parasitized eggs which placed in the central part, but female parasitoid of T. brassicae moved straight on cardboard and parasitized closer eggs in the end days of life (5th and 6th days). The maximum daily parasitized eggs by T. brassicae was 13.03±0.56 at the beginning of its oviposition period. Then, it decreased significantly with adult female age. The female age influenced hatch rate (%) of T. brassicae eggs. Its values were ranged from 95.07±0.82% (1st day of oviposition period) to 42.78±6.43% (6th day of oviposition period) in different days of adult female age. The highest values for sex ratio were estimated to be in the first 3 days of adult female life. The female-biased sex ratio decreased significantly with increasing adult female age. For efficient mass rearing of T. brassiace on E. kuehniella , parasitoids should not be kept more than three days in cultures because the progeny becomes male-biased and parasitism rate decreased significantly after 3rd days. Results of this study show good potential of T. brassicae and it suggest for mass rearing and to use in augmentative biological control program.
A Perspective on Substorm Dynamics Using 10 Years of Auroral Kilometric Radiation Observations From Wind

We study 10 years (1995–2004 inclusive) of auroral kilometric radiation (AKR) radio emission data from the Wind spacecraft to examine the link between AKR and terrestrial substorms. We use substorm lists based on parameters including ground magnetometer signatures and geosynchronous particle injections as a basis for superposed epoch analyses of the AKR data. The results for each list show a similar, clear response of the AKR power around substorm onset. For nearly all event lists, the average response shows that the AKR power begins to increase around 20 min prior to expansion phase onset, as defined by the respective lists. The analysis of the spectral parameters of AKR bursts show that this increase in power is due to an extension of the source region to higher altitudes, which also precedes expansion phase onset by 20 min. Our observations show that the minimum frequency channel that observes AKR at this time, on average, is 60 kHz. AKR visibility is highly sensitive to observing spacecraft location, and the biggest radio response to substorm onset is seen in the 21:00–03:00 hr local time sector.