Miracle-dz/UniFAR-FTUs huggingface dataset:
Subacute Sclerosing Panencephalitis in Children: The Archetype of Non-Vaccination

Subacute sclerosing panencephalitis (SSPE) is a late complication of measles virus infection that occurs in previously healthy children. This disease has no specific cure and is associated with a high degree of disability and mortality. In recent years, there has been an increase in its incidence in relation to a reduction in vaccination adherence, accentuated by the COVID-19 pandemic. In this article, we take stock of the current evidence on SSPE and report our personal clinical experience. We emphasise that, to date, the only effective protection strategy against this disease is vaccination against the measles virus.
Hot Melt Extrusion-Triggered Amorphization as a Continuous Process for Inducing Extended Supersaturable Drug Immediate-Release from saSMSDs Systems

Hot melt extrusion (HME), a continuous manufacturing process for generating supersaturating amorphous self-micellizing solid dispersion systems (saSMSDs), holds promise for achieving amorphization of many pharmaceutical formulations. For saSMSDs generation, HME-triggered continuous processes offer advantages over traditional non-continuous processes such as fusion/quench cooling (FQC) and co-precipitation (CP). Here we employed HME, FQC, and CP to generate saSMSDs containing the water-insoluble BCS II drug nitrendipine (NIT) and self-micellizing polymer Soluplus®. Scanning electron microscopy, powder X-ray diffraction, and differential scanning calorimetry results revealed that saSMSDs formed when NIT–Soluplus® mixtures were subjected to the abovementioned amorphization methods. All saSMSDs outperformed crystalline NIT preparations and physical mixtures in achieving extended supersaturable immediate release states with superior solubility, “spring-parachute” process characteristics, and dissolution behaviors. Notably, Fourier transform-infrared spectroscopic results obtained for saSMSDs detected hydrogen bonding interactions between the drug and the carrier. Ultimately, our results revealed the advantages of HME-triggered amorphization as a continuous process for significantly improving drug dissolution, increasing solubility, and maintaining supersaturation as compared to traditional amorphization-based techniques.
Discretization-Free Particle-Based Taxi Dispatch Methods With Network Flow Decomposition

The increasing popularity of on-demand ride-hailing services has introduced research problems, including those related to fleet management. Many existing fleet management approaches discretize a spatiotemporal distribution to reduce the problem complexity. Although spatial discretization greatly simplifies the problems, this approximation results in a suboptimal solution. To address this limitation, we present a novel spatial discretization-free, particle-based formulation of fleet management. Our model requires only temporal discretization. The nodes in our spatiotemporal network model represent the positions of the fleet and ride requests over the time horizon. Under this representation, a taxi dispatch problem can be solved by the minimum-cost maximum-flow (MCMF) algorithm. We show some structural properties that disclose a type of monotonicity by applying the MCMF algorithm to our problem. The obtained dispatch solution maximizes the number of served requests from these structural properties at least at the most current time step, regardless of the demand prediction quality. Moreover, these properties enable the decomposition of the MCMF algorithm without sacrificing optimality, and the decomposed multistage maximum-flow algorithm is significantly faster than the MCMF algorithm. Furthermore, we propose an efficient method that alleviates the dearth of input data for service providers who lack sufficient computing power to calculate substantial travel time information. We demonstrate the performance of our method by using data collected in New York City, USA. Our simulation studies indicate that a service provider can fulfill 74–85% of the ride requests within 2 minutes.
Macroeconomic Determinants of Household Debt in OECD Countries

This article investigates the macroeconomic determinants of household debt in developed economies using a sample comprising 26 OECD countries for the period of 2002q1–2020q4. By resorting to the unconditional quantile regression, we find relevant asymmetries in the response of household debt. According to our results, economic growth leads to lower household debt, but the beneficial effect decreases as the level of household debt increases. Inflation lowers household borrowing only if the level of debt is high. Higher house prices lead to higher household debt, with the impact becoming stronger as the level of debt is higher. Investments go hand in hand with household debt, and higher investments lead to higher levels of borrowing, even when household debt is already high. Mortgage credit interest rates are positively linked with household debt, starting with higher debt levels. A rising unemployment rate leads to lower household debt, but the link becomes weaker as the level of debt increases. Higher public expenditures are generally associated with lower household debt. In addition, we find that household debt exhibits very powerful autoregressive behavior, being difficult to reduce rapidly in the case of need.
Prevalence and Associated Factors of Burnout Risk among Emergency Nurses during COVID-19 Pandemic

Introduction: The Emergency Department (ED) nurses are the first health care professionals to treat patients infected during COVID-19 pandemic. The workload of ED nurses is quite heavy because generally patients who are rushed to the ED are emergency patients who need to get health services as quickly and accurately as possible. This study aimed to determine the prevalence and associated factors of burnout risk among Emergency Nurses during COVID-19 pandemic in Bali. Methods: A cross-sectional study was carried out on the risk of burnout among emergency nurses in Bali. This research was conducted in June 2021 involving 85 emergency nurses who are members of the Indonesian emergency and disaster nurse association in Bali. The instrument used to identify the nurses’ burnout is the Maslach Burnout Inventory Indonesian version. Statistical analysis was carried out using the Spearman Rank test with a level of significance (α<0.05). Results: The ED nurses burnouts during the COVID-19 pandemic in Bali have average burnout ranged from 9.8 to 34.58. Most of the respondents (72.9%) were in mild emotional exhaustion, 69.4% experienced moderate depersonalization and 45.9% had low personal accomplishment. Hospital resource have co-morbidities and previous experience of treating patients with infectious diseases statistically correlated with ED nurses burnouts.
Understanding the Anti-Hypertensive Potentials of Natural Resources

Hypertension is a major health problem that may progress to additional heart and circulatory problems. The two most frequent types of hypertension are primary or essential hypertension and secondary hypertension. Hypertension is a prevalent component of coronary heart disease, stroke, and renal vascular disease. Herbal remedies have been used for millions of years to treat and cure hypertension with fewer adverse effects. The overall purpose of this study is to collect data on the anti-hypertensive advantages of natural herbs in animal research and human involvement, as well as to recreate the underlying mechanisms, beginning with cell culture and ex vivo tissue data. According to the World Health Organization, natural herbs/shrubs are increasingly being used to treat almost all human ailments (WHO). Plants are used as immune boosters to increase the body’s natural capacity to tackle numerous health concerns, as well as herbal drugs and diet. Natural plant treatments are used by 80 percent of the world’s population (about 5.6 billion people) for significant health conditions. The historic use, phytochemical components, and pharmacological qualities of medicinal plants used to regulate hypertension are the topic of this research.
Pengaruh Kualitas Layanan Mobile Banking terhadap Kepuasan dan Loyalitas Nasabah Bank BUMN di Makassar

Advances in banking technology provide convenience for customers through operational services in the form of mobile banking that allows customers to perform banking transactions through smartphones. The purpose of this study was to determine the influence of mobile banking service quality on customer satisfaction and loyalty of BUMN Bank (State-Owned Enterprises), namely Bank BRI, Bank BNI, Bank BTN, and Bank Mandiri in Makassar, South Sulawesi. This study uses a quantitative approach. Data was collected by distributing questionnaires to 120 customers using the purposive sampling technique. The data that has been collected were analyzed using SPSS (Statistical Product and Service Solutions) version 23.0. The results of this study indicate that the quality of mobile banking services has a positive and significant effect on customer satisfaction and loyalty, while customer satisfaction has a significant effect on their loyalty. Furthermore, the quality of mobile banking services has a significant effect on loyalty mediated by customer satisfaction.
Nutrition Management for Critically Ill Adult Patients Requiring Non-Invasive Ventilation: A Scoping Review

Nutrition management is a core component of intensive care medicine. Despite the increased use of non-invasive ventilation (NIV) for the critically ill, a paucity of evidence on nutrition management precludes recommendations for clinical practice. A scope of the available literature is required to guide future research on this topic. Database searches of MEDLINE, Embase, Scopus, Web of Science, and Google Scholar were conducted to identify original research articles and available grey literature in English from 1 January 1990 to 17 November 2021 that included adult patients (≥16 years) receiving NIV within an Intensive Care Unit. Data were extracted on: study design, aim, population, nutrition concept, context (ICU type, NIV: use, duration, interface), and outcomes. Of 1730 articles, 16 met eligibility criteria. Articles primarily included single-centre, prospective, observational studies with only 3 randomised controlled trials. Key concepts included route of nutrition (n = 7), nutrition intake (n = 4), energy expenditure (n = 2), nutrition status (n = 1), and nutrition screening (n = 1); 1 unpublished thesis incorporated multiple concepts. Few randomised clinical trials that quantify aspects of nutrition management for critically ill patients requiring NIV have been conducted. Further studies, particularly those focusing on the impact of nutrition during NIV on clinical outcomes, are required to inform clinical practice.
Analysis of Electromagnetic Effects on Vibration of Functionally Graded GPLs Reinforced Piezoelectromagnetic Plates on an Elastic Substrate

A new nanocomposite piezoelectromagnetic plate model is developed for studying free vibration based on a refined shear deformation theory (RDPT). The present model is composed of piezoelectromagnetic material reinforced with functionally graded graphene platelets (FG-GPLs). The nanocomposite panel rests on Winkler–Pasternak foundation and is subjected to external electric and magnetic potentials. It is assumed that the electric and magnetic properties of the GPLs are proportional to those of the electromagnetic materials. The effective material properties of the plate are estimated based on the modified Halpin–Tsai model. A refined graded rule is introduced to govern the variation in the volume fraction of graphene through the thickness of the plate. The basic partial differential equations are provided based on Hamilton’s principle and then solved analytically to obtain the eigenfrequency for different boundary conditions. To check the accuracy of the present formulations, the depicted results are compared with the published ones. Moreover, impacts of the variation in elastic foundation stiffness, plate geometry, electric potential, magnetic potential, boundary conditions and GPLs weight fraction on the vibration of the smart plate are detailed and discussed.
A SECURITY ASPECT IN EMERGENCY DRIVING

The general structure is dependent on the AT89S52 microcontroller. Even the key role of DTMF continues to be implied by the aid of which appropriate user can control the safety options of car if it's thievery. The GPS navigation module offers the place to GSM that will further sent towards the user through message. To be able to retrieve the place of car by hand, the consumer will be sending message particularly format on GSM, that will further allows GPS navigation. It's embedded the idea of wireless communication i.e. zigbee and GSM and lots of other sensors by the aid of which immediate help could be shipped to the one who has met by having an accident. Research content uses we've got the technology of signee for that transmission of message to another vehicle within the duration of necessity of their help and for serving the mark of secure driving the functions like motorists alcohol recognition, vehicle speed slowing down and automatic vehicle lock with collision recognition can be used. These studies is essentially with a digital camera that you can use during the time of emergency while worries. The GPS navigation may also be used for locating the exact vehicle location in order that it is available if lost.
Changes in Organic Carbon in Mineral Topsoil of a Formerly Cultivated Arenosol under Different Land Uses in Lithuania

This study aims to determine the differences in the organic carbon, humic acid (HA), and fulvic acid (FA) concentrations in the A and AB horizons, depending on land use, in order to determine the influence of the land use on the soil organic carbon (SOC) sequestration rate in the A horizon, and to assess the impact of the land use on the quality of the humic substances (HS) (the humification rate (HR) and the HA/FA ratio). On the basis of the data of 1995–2018, it would be expedient to convert cropland (CL) areas to fertilized managed grassland (MGfert) in order to increase the SOC accumulation (28%) in the Arenosol. In the unfertilized managed grassland (MGunfer) areas, the SOC accumulation in the A horizon was similar to that in the MGfert (p > 0.05); however, significantly less (−45.0%) HAs were formed, the HR decreased 2.8%, and the HA/FA ratio was 1.12%. This means that less stable humic substances were formed in the MGunfer soil. In the Arenosol, the fastest SOC sequestration took place in the AL and PP areas, the annual SOC stocks increased by 393 and 504 kg ha−1 year−1, respectively, and the HR increased to 19.1–21.3% (CLfert: 11.9%). However, these types of land use produce more FAs (14.5 and 32.5% more, respectively, compared to the MGfert, and 36.3 and 57.7% more, respectively, compared to the CLfert), which can lead to soil acidification and can accelerate eluvial processes. Because of the faster leaching of the FAs from the upper layers of the A horizon to the AB horizon, the humus type changes from humate–fulvate in the A horizon, to fulvate–humate in the AB horizon.
Linezolid-Resistant Enterococcus spp. Isolates from Foods of Animal Origin—The Genetic Basis of Acquired Resistance

Enterococci are important opportunistic pathogens with the capacity to acquire and spread antibiotic resistance. At present, linezolid-resistant enterococci (LRE) pose a great challenge. Linezolid is considered as a last resort antibiotic in the treatment of enterococcal infections, so it is important to monitor the occurrence of LRE in various environments. The aim of this study was to define the genetic mechanisms of linezolid resistance in enterococci (E. faecalis, E. faecium, E. hirae, E. casseliflavus) isolated from foods of animal origin (n = 104). Linezolid resistance (LR) was shown by 26.9% of isolates. All of them displayed linezolid MICs of 8–32 µg/mL, and 96.4% of them were multidrug multidrug-resistant. The most common acquired linezolid resistance gene in LR isolates was poxtA (64%), followed by optrA (28%) and cfr (12%). According to the authors’ knowledge, this research is the first to indicate the presence of the cfr gene among isolates from food. In 28.6% of the isolates, the point mutation G2576T in the V domain of the 23S rRNA was responsible for linezolid resistance. All isolates harbored the wild-type rplC, rplD and rplV genes. The obtained results indicate that linezolid resistance among enterococci in animal-derived food may result from various genetic mechanisms. The most worrying is that this resistance is encoded on mobile genetic elements, so there is a risk of its rapid transmission, even despite the lack of selective pressure resulting from the use of antibiotics.
Patient Satisfaction and Its Predictors in the General Hospitals of Southwest Saudi Arabia: A Cross-sectional Survey

Background: Patient satisfaction occupies a central position in measuring the quality of care as it provides information on the provider's success, meeting the patient’s values and expectations. Hence, it is an essential tool for assessing health services outcomes. This study aimed to assess patients' satisfaction level and factors influencing healthcare quality of general hospitals in the Jazan region, Saudi Arabia (SA). Methods: This observational cross-sectional study was conducted on a sample of 423 patients selected through stratified random sampling from general hospitals of the Jazan region. Results: The overall satisfaction rate among the study participants was 80.9%. Satisfaction with food services was the highest (91.15%) followed by doctor services (81.0%), reception and entry procedures (80%), and nursing services (78.15%). The various aspects of satisfaction with doctors and nurses included the treatment prescribed by physicians, clarity in communication with patients, compassion and providing clear explanation of what they were doing. However, about 27.3% of the patients were dissatisfied with the length of waiting period before seeing a doctor. Binary logistic regression analysis suggested that uneducated patients and patients with secondary school education were more likely to have higher satisfaction level than university-educated patients (OR = 3.40, 95% C.I. [1.56–7.45], p = 0.002), (OR = 2.66, 95% C.I. [1.28–5.55], p = 0.009), and (OR = 2.29, 95% C.I. [1.40–3.73], p = 0.001), respectively. Conclusion: The health services satisfaction level was high in the Jazan population. However, some aspects of dissatisfaction were reported, such as the long waiting period before seeing a doctor. These aspects are recommended to be improved to ensure that the services provided by general hospitals are of high quality.
Effects of a ZnCuO-Nanocoated Ti-6Al-4V Surface on Bacterial and Host Cells

This study aims to investigate the effects of a novel ZnCuO nanoparticle coating for dental implants—versus those of conventional titanium surfaces—on bacteria and host cells. A multispecies biofilm composed of Streptococcus sanguinis, Actinomyces naeslundii, Porphyromonas gingivalis, and Fusobacterium nucleatum was grown for 14 days on various titanium discs: machined, sandblasted, sandblasted and acid-etched (SLA), ZnCuO-coated, and hydroxyapatite discs. Bacterial species were quantified with qPCR, and their viability was examined via confocal microscopy. Osteoblast-like and macrophage-like cells grown on the various discs for 48 h were examined for proliferation using an XTT assay, and for activity using ALP and TNF-α assays. The CSLM revealed more dead bacteria in biofilms grown on titanium than on hydroxyapatite, and less on sandblasted than on machined and ZnCuO-coated surfaces, with the latter showing a significant decrease in all four biofilm species. The osteoblast-like cells showed increased proliferation on all of the titanium surfaces, with higher activity on the ZnCuO-coated and sandblasted discs. The macrophage-like cells showed higher proliferation on the hydroxyapatite and sandblasted discs, and lower activity on the SLA and ZnCuO-coated discs. The ZnCuO-coated titanium has anti-biofilm characteristics with desired effects on host cells, thus representing a promising candidate in the complex battle against peri-implantitis.
Long-Term Analysis of Resilience of the Oral Microbiome in Allogeneic Stem Cell Transplant Recipients

Stem cell transplantation (SCT) is associated with oral microbial dysbiosis. However, long-term longitudinal data are lacking. Therefore, this study aimed to longitudinally assess the oral microbiome in SCT patients and to determine if changes are associated with oral mucositis and oral chronic graft-versus-host disease. Fifty allogeneic SCT recipients treated in two Dutch university hospitals were prospectively followed, starting at pre-SCT, weekly during hospitalization, and at 3, 6, 12, and 18 months after SCT. Oral rinsing samples were taken, and oral mucositis (WHO score) and oral chronic graft-versus-host disease (NIH score) were assessed. The oral microbiome diversity (Shannon index) and composition significantly changed after SCT and returned to pre-treatment levels from 3 months after SCT. Oral mucositis was associated with a more pronounced decrease in microbial diversity and with several disease-associated genera, such as Mycobacterium, Staphylococcus, and Enterococcus. On the other hand, microbiome diversity and composition were not associated with oral chronic graft-versus-host disease. To conclude, dysbiosis of the oral microbiome occurred directly after SCT but recovered after 3 months. Diversity and composition were related to oral mucositis but not to oral chronic graft-versus-host disease.