Miracle-dz/UniFAR-FTUs huggingface dataset:
Effect of Different Definitive Impression Techniques for Resorbed Mandibular Ridge on Retention of a Lower Complete Denture.

AIM This study aimed to evaluate the effect of different definitive impression techniques for the resorbed mandibular ridge on the retention of lower complete dentures. MATERIALS AND METHODS Ten completely edentulous male patients with severe atrophic mandibular ridge were selected from the Prosthodontic Department's outpatient clinic, Faculty of Dentistry, Sinai University (Kantara branch). Each patient received four dentures. Dentures were divided into four groups according to the type of final impression, Group I: Conventional impression techniques (open mouth technique), Group II: Cocktail impression techniques, Group III: Modified functional impression technique, and Group IV: Wire impression technique. Each denture was used for one month and at the end of the month the retention test was carried out and the results were tabulated and statistically analyzed. RESULTS There is a statistically significant difference between the groups. The results also showed that the highest mean value was in group IV, whereas the lowest mean value of retention was in group I. CONCLUSION Wire impressions produce lower dentures with higher retention, whereas conventional impressions produce lower dentures with the lowest retention, so it is considered to be more advantageous. CLINICAL SIGNIFICANCE The wire impression technique is superior in the management of resorbed ridges as compared with other techniques.
Time‐Resolved Measurements of PM2.5 Chemical Composition and Brown Carbon Absorption in Nanjing, East China: Diurnal Variations and Organic Tracer‐Based PMF Analysis

To understand diurnal variations in PM2.5 composition and aerosol extract absorption, PM2.5 samples were collected at intervals of 2 hr from 8:00 to 20:00 and 6 hr from 20:00 to 8:00 (the next day) in northern Nanjing, China, during the winter and summer of 2019–2020 and analyzed for bulk components, organic tracers, and light absorption of water and methanol extracts—a proxy measure of brown carbon (BrC). Diurnal patterns of measured species reflected the influences of primary emissions and atmospheric processes. Light absorption coefficients of water (Abs365,w) and methanol extracts (Abs365,m) at 365 nm shared a similar diurnal profile peaking at 18:00–20:00, generally following changes in biomass burning tracers. However, Abs365,w, Abs365,m, and their normalizations to organic aerosols increased at 14:00–16:00, earlier than that of levoglucosan in the late afternoon, which was attributed to secondarily formed BrC. The methanol extracts showed a less drastic decrease in light absorption at night than the water extracts and elevated absorption efficiency during 2:00–8:00. This is due to the fact that the water‐insoluble OC has a longer lifetime and stronger light absorption than the water‐soluble OC. According to the source apportionment results solved by positive matrix factorization (PMF), biomass burning and secondary formation were the major BrC sources in northern Nanjing, with an average total relative contribution of about 90%. Compared to previous studies, diurnal source cycles were added to the PMF simulations in this work by using time‐resolved speciation data, which avoided misclassification of BrC sources.
UTILIZATION OF AGRICULTURAL WASTE AND BIOLOGICAL AGENTS TO INCREASE RICE YIELD

Agricultural waste can be fermented into liquid organic fertilizer to provide nutrition and phytohormon for plants. The application of this liquid organic fertilizer will improve nutrient availability, the root morphology, growth and yield of plants. The objective of this research was to examine the effect of NPK synthetic fertilizers and different types of Liquid Organic Fertilizer (LOF) on plant growth and rice yield. The experiment was conducted at Bener Village, Ngrampal sub-district, Sragen district, Indonesia, from March until November 2011. The experiment was developed according to Randomized Completely Block Design with five replicates. The treatments were: LOF “Double”, LOF “Plus”, LOF “Bacteria”, LOF “Bacteria+Plus”, and NPK fertilizers (Control without LOF). Plant growth was measured weekly on five plant samples and plant yield was assessed at harvest time. The data was subjected to an analysis of variance followed by Duncan’s Multiple Range Test. The results showed that plants treated with synthetic fertilizer (NPK, Control) have the lowest plant growth and rice yield compared to those treated with LOF. The types of fertilizer applied did not affect the number of tillers. Plants treated with LOF “Bacteria+Plus” or LOF "Plus" displayed more leaves and better plant height of than those treated with LOF “Double” or synthetic fertilizer. Plants treated with LOF “Bacteria+Plus” or LOF "Plus" had a significantly higher number of seed/panicles, grain weight per hill, per plot and per hectare than those treated with LOF “Double” or synthetic fertilizer. KEY WORDS: Biological agents, agricultural waste, liquid organic fertilizer, rice
I Like This New Me: Unravelling Population Structure of Mediterranean Electric Rays and Taxonomic Uncertainties within Torpediniformes

Simple Summary Electric rays are currently poorly investigated; therefore, their biological status, species identification and distribution are often hard to assess. The present work, using mitochondrial sequence data, aimed to investigate (1) the genetic diversity of the three species of electric rays reported in the Mediterranean Sea (Torpedo torpedo, Torpedo marmorata and Tetronarce nobiliana); and (2) the possible occurrence of other hidden species in the area. Our results suggest that (1) the Sardinian seas (Western Mediterranean) host populations characterized by high levels of genetic diversity, significantly different from other areas located in the Eastern Mediterranean basin, deserving special attention; (2) only three species occur in the investigated area; (3) inaccuracies exist in the current taxonomy of the three investigated species, such as the possible occurrence of cryptic species outside the Mediterranean Sea, as well as in other genera/families of the order Torpediniformes. Future studies are needed to address these issues and inform effective conservation measures. Abstract The present study focused on the three species of electric rays known to occur in the Mediterranean Sea: Torpedo torpedo, Torpedo marmorata and Tetronarce nobiliana. Correct identification of specimens is needed to properly assess the impact of fisheries on populations and species. Unfortunately, torpedoes share high morphological similarities, boosting episodes of field misidentification. In this context, genetic data was used (1) to identify specimens caught during fishing operations, (2) to measure the diversity among and within these species, and (3) to shed light on the possible occurrence of additional hidden species in the investigated area. New and already published sequences of COI and NADH2 mitochondrial genes were analyzed, both at a small scale along the Sardinian coasts (Western Mediterranean) and at a large scale in the whole Mediterranean Sea. High levels of genetic diversity were found in Sardinian populations, being significantly different from other areas of the Eastern Mediterranean Sea due to the biotic and abiotic factors here discussed. Sardinian torpedoes can hence be indicated as priority populations/areas to be protected within the Mediterranean Sea. Moreover, sequence data confirmed that only the three species occur in the investigated area. The application of several ‘species-delimitation’ methods found evidence of cryptic species in the three species outside the Mediterranean Sea, as well as in other genera/families, suggesting the urgent need for future studies and a comprehensive revision of the order Torpediniformes for its effective conservation.
Motor adaptation and immediate retention to overground gait-slip perturbation training in people with chronic stroke: an experimental trial with a comparison group

Background Perturbation-based training has shown to be effective in reducing fall-risk in people with chronic stroke (PwCS). However, most evidence comes from treadmill-based stance studies, with a lack of research focusing on training overground perturbed walking and exploring the relative contributions of the paretic and non-paretic limbs. This study thus examined whether PwCS could acquire motor adaptation and demonstrate immediate retention of fall-resisting skills following bilateral overground gait-slip perturbation training. Methods 65 PwCS were randomly assigned to either (i) a training group, that received blocks of eight non-paretic (NP-S1 to NP-S8) and paretic (P-S1 to P-S8) overground slips during walking followed by a mixed block (seven non-paretic and paretic slips each interspersed with unperturbed walking trials) (NP-S9/P-S9 to NP-S15/P-S15) or (ii) a control group, that received a single non-paretic and paretic slip in random order. The assessor and training personnel were not blinded. Immediate retention was tested for the training group after a 30-minute rest break. Primary outcomes included laboratory-induced slip outcomes (falls and balance loss) and center of mass (CoM) state stability. Secondary outcomes to understand kinematic contributors to stability included recovery strategies, limb kinematics, slipping kinematics, and recovery stride length. Results PwCS within the training group showed reduced falls (p < 0.01) and improved post-slip stability (p < 0.01) from the first trial to the last trial of both paretic and non-paretic slip blocks (S1 vs. S8). During the mixed block training, there was no further improvement in stability and slipping kinematics (S9 vs. S15) (p > 0.01). On comparing the first and last training trial (S1 vs. S15), post-slip stability improved on both non-paretic and paretic slips, however, pre-slip stability improved only on the non-paretic slip (p < 0.01). On the retention trials, the training group had fewer falls and greater post-slip stability than the control group on both non-paretic and paretic slips (p < 0.01). Post-slip stability on the paretic slip was lower than that on the non-paretic slip for both groups on retention trials (p < 0.01). Conclusion PwCS can reduce laboratory-induced slip falls and backward balance loss outcomes by adapting their post-slip CoM state stability after bilateral overground gait-slip perturbation training. Such reactive adaptations were better acquired and retained post-training in PwCS especially on the non-paretic slips than paretic slips, suggesting a need for higher dosage for paretic slips. Clinical registry number NCT03205527
Bone Density, Geometry, Structure and Strength Estimates in Adolescent and Young Adult Women with Atypical Anorexia Nervosa versus Typical Anorexia Nervosa and Normal-Weight Healthy Controls

Our objective was to characterize bone outcomes in adolescent and young adult women with atypical anorexia nervosa (AAN) compared to typical AN and normal-weight healthy controls (HC) based on DSM-5 criteria. Four hundred thirty-two participants (141 AN, 131 AAN and 160 HC), ages 12–21 years, underwent dual-energy X-ray absorptiometry for areal BMD, and a subset had high-resolution peripheral quantitative CT assessment of the distal radius and tibia for volumetric BMD (vBMD), bone geometry and microarchitecture, and microfinite element analysis for estimated strength. The groups did not differ for age, pubertal stage, menarcheal age or physical activity. BMI and bone outcomes overall were intermediate in AAN compared with AN and HC. This applied to spine, total hip and femoral neck BMD measures and many distal tibial measures. However, the mean whole-body less head BMD Z-score did not differ between AAN and AN, and it was lower in both vs. HC. Similarly, many distal radius measures did not differ between AAN vs. AN or HC but were lower in AN than HC. Lower BMI, lean mass and bone age, older menarcheal age and longer illness duration correlated with greater impairment of bone outcomes. These data indicate that individuals with AAN overall have bone outcomes that are intermediate between AN and HC.
Association Between Musculoskeletal Pain and Studying Hours Among Medical Students in Jeddah, Saudi Arabia

Introduction Musculoskeletal (MSK) disorders are one of the common health issues affecting people of various ages. The main risk factors for musculoskeletal pain are age, obesity, gender, level of education, psychosocial factors, occupational factors, decreased mobility and flexibility, and common factors such as consuming TV and video games. College students, especially medical students, are at a higher risk of these complaints as they have longer hours of studying than most faculties due to the competitiveness of their specialty. The objective of this study was to identify the relationship between musculoskeletal pain and studying hours in medical students in Jeddah, Saudi Arabia, and to increase awareness of this problem. Methods This cross-sectional study was conducted in 2022. Data was collected using an online questionnaire. A total of 314 participants were included in this study. The demographic variables, studying hours, studying locations, and postures were collected and analyzed. Results A total of 314 medical students were included in this study. The majority were males (71.0%) and, the mean age was 22.05±2.13 years. Most of them were sixth-year students, and most of them reported studying between three and four hours (40.1%), with the most common studying location reported being the students' home or residence (79.3%). The number of daily studying hours had no significant effect on the occurrence of musculoskeletal problems. Conclusion There was no significant relationship between the number of studying hours and the MSK pain. Clinical trials could be used to evaluate the most effective approaches to alleviate MSK pain in medical students.
Identifying New Contributors to Brain Metastasis in Lung Adenocarcinoma: A Transcriptomic Meta-Analysis

Simple Summary Lung cancer patients have a high mortality risk due to brain metastases (BM). Understanding the molecular changes that contribute to BM is essential to identify potential therapeutic targets. Previous research has focused on primary tumor alterations, with less attention given to BM. This study examined a unique transcriptomic dataset assembled from previously reported RNA-seq, microarray, and single-cell analyses of BM samples from lung adenocarcinoma (LUAD) patients in pursuit of gaining a better understanding of the molecular landscape of BM. We found that dendritic cells and neutrophils were present in LUAD-BM, which could contribute to an immunosuppressive tumor microenvironment. The expression levels of 102 genes were altered, with CD69 and GZMA identified as ‘hub’ genes, which could play a role in LUAD-BM. BM-specific gene expression was also observed, further supporting the presence of an immunosuppressive tumor microenvironment. Abstract Lung tumors frequently metastasize to the brain. Brain metastasis (BM) is common in advanced cases, and a major cause of patient morbidity and mortality. The precise molecular mechanisms governing BM are still unclear, in part attributed to the rarity of BM specimens. In this work, we compile a unique transcriptomic dataset encompassing RNA-seq, microarray, and single-cell analyses from BM samples obtained from patients with lung adenocarcinoma (LUAD). By integrating this comprehensive dataset, we aimed to enhance understanding of the molecular landscape of BM, thereby facilitating the identification of novel and efficient treatment strategies. We identified 102 genes with significantly deregulated expression levels in BM tissues, and discovered transcriptional alterations affecting the key driver ‘hub’ genes CD69 (a type II C-lectin receptor) and GZMA (Granzyme A), indicating an important role of the immune system in the development of BM from primary LUAD. Our study demonstrated a BM-specific gene expression pattern and revealed the presence of dendritic cells and neutrophils in BM, suggesting an immunosuppressive tumor microenvironment. These findings highlight key drivers of LUAD-BM that may yield therapeutic targets to improve patient outcomes.
Testosterone deficiency impairs cardiac interfibrillar mitochondrial function and myocardial contractility while inducing oxidative stress

Introduction Clinical studies have shown that low levels of endogenous testosterone are associated with cardiovascular diseases. Considering the intimate connection between oxidative metabolism and myocardial contractility, we determined the effects of testosterone deficiency on the two spatially distinct subpopulations of cardiac mitochondria, subsarcolemmal (SSM) and interfibrillar (IFM). Methods We assessed cardiac function and cardiac mitochondria structure of SSM and IFM after 12 weeks of testosterone deficiency in male Wistar rats. Results and Discussion Results show that low testosterone reduced myocardial contractility. Orchidectomy increased total left ventricular mitochondrial protein in the SSM, but not in IFM. The membrane potential, size and internal complexity in the IFM after orchidectomy were higher compared to the SHAM group. However, the rate of oxidative phosphorylation with all substrates in the IFM after orchidectomy was lower compared to the SHAM group. Testosterone replacement restored these changes. In the testosterone-deficient SSM group, oxidative phosphorylation was decreased with palmitoyl-L-carnitine as substrate; however, the mitochondrial calcium retention capacity in IFM was increased. There was no difference in swelling of the mitochondria in either group. These changes in IFM were followed by a reduction in phosphorylated form of AMP-activated protein kinase (p‐AMPK‐α), peroxisome proliferator‐activated receptor gamma coactivator 1‐alpha (PGC‐1α) translocation to mitochondria and decreased mitochondrial transcription factor A (TFAM). Testosterone deficiency increased NADPH oxidase (NOX), angiotensin converting enzyme (ACE) protein expression and reduced mitochondrial antioxidant proteins such as manganese superoxide dismutase (Mn-SOD) and catalase in the IFM. Treatment with apocynin (1.5 mM in drinking water) normalized myocardial contractility and interfibrillar mitochondrial function in the testosterone depleted animals. In conclusion, our findings demonstrate that testosterone deficiency leads to reduced myocardial contractility and impaired cardiac interfibrillar mitochondrial function. Our data suggest the involvement of reactive oxygen species, with a possibility of NOX as an enzymatic source.
Coastal bathymetry using 8-color multispectral satellite observation of wave motion

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Self-reported traumatic brain injury in a sample of impulsive violent offenders: neuropsychiatric correlates and possible “dose effects”

Background Traumatic brain injury (TBI) is a major public health problem that may be associated with numerous behavioral problems, including impulsivity, aggression and violence. Rates of self-reported TBI are high within offender populations, but the extent to which TBI is causally implicated in causing illegal behavior is unclear. This study examined the psychological and functional correlates of histories of traumatic brain injury in a sample of impulsive violent offenders. Methods Study participants, all men, had been recruited to participate in a randomized controlled trial of sertraline to reduce recidivism. Study entry criteria were an age of at least 18 years, a documented history of two or more violent offenses and a score of 70 or above on the Barratt Impulsiveness Scale. An extensive list of standardized questionnaires was administered to obtain information on previous TBI and other neuropsychiatric conditions or symptoms. Results In the sample of 693 men, 66% were aged between 18 and 35 years old, and 55% gave a history of TBI (“TBI+”). Overall, 55% of study participants reported at least one TBI. High levels of neuropsychiatric symptomatology were reported. In 75% of TBI+ individuals, their most severe TBI (by self-report) was associated with loss of consciousness (LOC) < 30 min. Compared to TBI- (those without history of TBI) participants, TBI+ individuals were more impulsive (Eysenck Impulsivity), irritable, angry, and reported higher levels of assaultive behavior, depressive symptomology, alcohol use disorder, suicidal ideation, suicide attempts, and lower quality of life. Potential “dose effects” of TBI severity and frequency in terms of neuropsychiatric symptomatology were identified. Conclusion Like other studies of offender populations, single and multiple TBIs were very common. The associations of TBI, TBI severity, and TBI frequency (i.e., TBI “burden”) with adverse neuropsychiatric phenomena suggest TBI contributes importantly to offender morbidity but the select nature of the sample and cross-sectional study design constrain the interpretation of these findings.
Evaluation of the Bearing Capacity of the Board Pile in Collapsible Soil using A Laboratory Model

The pile’s ultimate capacity or failure load must be computed by some criteria using load-settlement curve data gathered during the pile load test. Many scholars have proposed several approaches for evaluating the pile’s ultimate capacity in the past. This study compared different failure criteria to predict the ultimate load capacity for piles with two different lengths-to-diameter ratios embedded in gypseous soil with gypsum content of 60% under soaked and unsoaked conditions. Two types of piles were used. Floating pile and end-bearing pile. Davisson, Brinch Hansen’s 80 percent, Chin-Kondner, Mazurkiewicz’s, and Brinch Hansen’s 90 methods that were used in this study predict a higher value of the ultimate pile capacity, whereas the Decourt Extrapolation method gave fluctuated value. Fuller and Hoy’s, Butler and Hoy’s methods give far away value from realistic. On the other hand, Shen’s, ASTM, Terzaghi, and DeBeer’s methods predicted an acceptable and realistic value. The failure criterion of (15%D) where (D) is pile diameter according to(ASTM D-1143) was adopted in this type of soil.