Miracle-dz/UniFAR-FTUs huggingface dataset:
The Effects of Peptide Receptor Radionuclide Therapy on the Neoplastic and Normal Pituitary

Simple Summary Few therapies are available for patients with aggressive or metastatic pituitary neuroendocrine tumours (PitNETs). Peptide receptor radionuclide therapy (PRRT), widely used to treat gastroenteropancreatic neuroendocrine tumours, has been emerging as a potential option for aggressive or metastatic PitNETs if other treatment approaches are not feasible or failed in controlling the disease progression. However, the data regarding the use of PRRT in this setting is scarce, and mainly derives from few case reports or small series of cases. Here, we review the published data regarding the effectiveness and safety of PRRT in the management of aggressive or metastatic PitNETs, as well as the effects of PRRT on the pituitary function in other cancer patients. Abstract Pituitary neuroendocrine tumours (PitNETs) are usually benign and slow-growing; however, in some cases, they may behave aggressively and become resistant to conventional treatments. Therapeutic options for aggressive or metastatic PitNETs are limited, and currently mainly consist of temozolomide, with little experience of other emerging approaches, including peptide receptor radionuclide therapy (PRRT). Somatostatin receptor expression in PitNETs explains the effectiveness of somatostatin analogues for treating PitNETs, particularly those hypersecreting pituitary hormones, such as growth hormone or adrenocorticotropic hormone. The expression of such receptors in pituitary tumour cells has provided the rationale for using PRRT to treat patients with aggressive or metastatic PitNETs. However, the PRRT efficacy in this setting remains unestablished, as knowledge on this today is based only on few case reports and small series of cases, which are reviewed here. A total of 30 PRRT-treated patients have been thus far reported: 23 aggressive PitNETs, 5 carcinomas, and 2 of malignancy status unspecified. Of the 27 published cases with information regarding the response to PRRT, 5 (18%) showed a partial response, 8 (30%) had stable disease, and 14 (52%) had progressive disease. No major adverse effects have been reported, and there is also no increased risk of clinically relevant hypopituitarism in patients with pituitary or non-pituitary neuroendocrine tumours following PRRT. PRRT may be regarded as a safe option for patients with aggressive or metastatic PitNETs if other treatment approaches are not feasible or have failed in controlling the disease progression, with tumour shrinkage occurring in up to a fifth of cases, while about a third of aggressive pituitary tumours may achieve stable disease. Here, the data on PRRT in the management of patients with aggressive pituitary tumours are reviewed, as well as the effects of PRRT on the pituitary function in other PRRT-treated cancer patients.
“Blinks in the Dark”: Blink Estimation With Domain Adversarial Training (BEAT) Network

Blink detection plays an important role in many human-computer interaction applications for consumers. Unfortunately, deep neural network-based blink detection methods are not only susceptible to poor lighting conditions, but also the deep learning model is prone to bias due to the imbalance in the dataset distribution. To solve these problems, we propose Blink Estimation with Domain Adversarial Training (BEAT) network, which robustly detects blinks in unseen out-of-sample images captured even under poor lighting conditions by extracting domain-invariant features. BEAT network is inspired by the domain-adversarial neural network (DANN) but improved with several improvements including a lambda scheduler to stabilize adversarial training and a gradient decay layer to prevent the discriminative loss from overwhelming the classification loss. As a result, BEAT achieves faster and more accurate blink detection performances than other domain generalization methods for unseen target domains. In particular, BEAT’s feature extractor model achieves state-of-the-art performance in terms of AUPR on popular benchmark datasets. Also, we suggest a practical optimal threshold for blink detection based on our insights gained from our experiments for consumer applications.
Effect of Different Levels of Phosphorus on Yield and Quality of Fodder Ricebean

A field experiment (kharif 2012) was conducted at the Central Research Farm (Gayeshpur), Bidhan Chandra Krishi Viswavidyalaya with two varieties [JRBJ-05-4 and Bidhan Ricebean-1] and four phosphorus levels [0, 30, 60 and 90 kg ha−1]. The results revealed that highest green fodder yield (367.20 q ha−1), dry matter yield (49.60 q ha−1) and crude protein yield (5.59 q ha−1) were obtained with variety Bidhan Ricebean-1. Application of phosphorus had a significant effect on both green fodder and dry matter yield. Application of phosphorus at the rate of 90 kg ha−1 gave the maximum green fodder yield (385.20 q ha−1) and application of phosphorus at the rate of 60 kg ha−1 gave the maximum dry matter yield (51.54 q ha−1). There was no significant difference between these two levels of phosphorus for green fodder and dry matter yield, while application of phosphorus at the rate of 90 kg ha−1 showed a positive effect on increasing crude protein yield.
Management of Intracranial Hemorrhage in the Setting of Mechanical Heart Valve Replacement Therapy

The management of an intracranial hemorrhage in patients receiving anticoagulant therapy presents a significant challenge for medical professionals. Anticoagulant treatment is intended to prevent blood clotting, but it can worsen active brain bleeds. Despite this risk, avoiding the prothrombotic state caused by mechanical heart valves remains crucial. Guidelines on managing this issue are currently lacking, prompting a review that delves into embryonic development and anatomical functions of heart valves, valve replacement therapy for diseased valves, and the need for anticoagulants. Ultimately, recent literature and cases inform discussion regarding how best to manage intracranial hemorrhages in patients with mechanical heart valves. The expectation is that this examination will offer valuable perspectives on the handling of intracranial bleeding among individuals with mechanical heart valves and stimulate additional investigations in this intricate domain, particularly through the lens of applied mechanics.
Fabrication of a curcumin encapsulated bioengineered nano-cocktail formulation for stimuli-responsive targeted therapeutic delivery to enhance anti-inflammatory, anti-oxidant, and anti-bacterial properties in sepsis management

Abstract This study aimed to fabricate an eco-friendly functionalized chitosan (CS) nanocarrier to establish a pH-responsive drug delivery system for the treatment of sepsis. Curcumin (Cur) and cerium oxide (CeO2) were loaded onto an octenylsuccinic anhydride (OSA)-functionalized CS nanoformulation (Cur@Ce/OCS) to achieve an effective nanocarrier (NC) for sepsis treatment. The physicochemical characteristics of the developed nanocarriers were determined using various characterization techniques. The developed CeO2-OCS nanoformulation has been showed effective anti-bacterial activity (∼97%) against G+ and G− bacterial pathogens, and also have improved drug loading (94% ± 2), and encapsulation efficiency (89.8% ± 1.5), with uniform spherical particles having an average diameter of between 100 and 150 nm. The in vivo experimental results establish that Cur-loaded Ce/OCS NPs could have enhanced therapeutic potential against lung infection model by reducing bacterial burden and extensively decreasing inflammatory responses in sepsis model. Additionally, we determined the in vivo biosafety of the nanoformulations by histological observation of different mouse organs (heart, liver, spleen, and kidney), and observed no signs of toxicity in the treatment groups. The findings of this study clearly demonstrate the therapeutic potential of pH-sensitive nanoplatforms in the management of infectious sepsis. Graphical Abstract
On the interchangeability and stochastic ordering of ·/M/1 queues in tandem

A probabilistic proof is given of the fact that the departure process from two initially empty. ·/M/1 queues in tandem is unaffected when the service rates are interchanged. As a consequence of this, we show that when the sum of the service rates at the two queues is held constant the departure process stochastically increases as the service rates become equal. The proofs are based on coupling of reflected random walks.
Exploring the Effects of Multiple Dimensions of Organizational Justice on Correctional Staff Job Stress

The primary purpose of the current study was to assess the role of organizational justice in understanding prison staff job stress. Specifically, the authors surveyed 322 correctional employees across two prisons located in Guangzhou, China to explore the effects of distributive, procedural, informational, and interpersonal justice on work stress. Results from ordinary least squares analysis revealed significant contributions from three dimensions of organizational justice in explaining stress from work among prison workers. Prison personnel who had higher perceptions of interpersonal, distributive, and procedural justice in the organization were less likely to report being stressed. In addition, men were more likely to report higher levels of work tension than women.
Microclimate Refugia: Comparing Modeled to Empirical Near-Surface Temperatures on Rangeland

Microhabitats can provide thermal niches that affect geographic range shifts of species as the climate changes and provide refuges for pest and beneficial insect populations in agricultural regions. The spatial distribution of microhabitats is influenced by topography that can influence local extinction and recolonization by animal populations. Scaling local temperature-dependent processes to a regional scale of population expansion, and contraction requires the validation of biophysical models of near surface temperatures. We measured temperature at 2.5 cm above and below ground at 25 sites in each of the two regions: southern and northern Utah, USA. Using NichMapR version 3.2. 0, we modeled the temperature at these same sites with local slopes and aspects for four years for the former and eight years for the latter region. Empirical and modeled air temperatures differed by 7.4 °C, on average, and soil temperatures differed less (4.4 °C, on average). Site-specific additions of hill shading at 25 m distance or soil parameters did not improve the agreement of the empirical and modeled temperatures. A hybrid model for air temperature that incorporated soil temperature at 0 cm depth when snow depth exceeded 3 cm resulted in an average improvement of 8% that was as great as 31%. Understanding biological processes at the regional scale and in projected future climates will continue to require biophysical modeling. To achieve the widest applications possible, biophysical models such as NichMapR need to be validated with empirical data from as wide a variety of altitudes, latitudes, soil types, and topographies wherein organisms currently inhabit and where their ranges might expand to in the future.
A comparison among strategies for interpolating maximum and minimum daily air temperatures. Part II: The interaction between number of guiding variables and the type of interpolation method

Abstract In a comparative experiment, the sequence of daily maximum and minimum temperatures for 1976 was interpolated over England and Wales to a resolution of 1 km using partial thin plate splines, ordinary kriging, trend surface, and an automatic inverse-distance-weighted method of interpolation. A “level playing field” for comparing the estimation accuracies was established through the incorporation of a consistent set of guiding variables in all interpolators. Once variables were included to guide the interpolators, differences in estimation accuracy among partial thin plate splines, ordinary kriging, and inverse distance weighting results were not significant although the performance of trend surface analysis was poorer. Best accuracies were achieved using partial thin plate splines, with jackknife cross-validation root-mean-square errors of 0.8°C for an annual series of daily maximum temperatures and 1.14°C for daily minimum temperatures. The results from this study suggest that sole reliance on th.
Tuning the Site-to-Site Interaction of Heteronuclear Diatom Catalysts MoTM/C2N (TM = 3d Transition Metal) for Electrochemical Ammonia Synthesis

Ammonia (NH3) synthesis is one of the most important catalytic reactions in energy and chemical fertilizer production, which is of great significance to the sustainable development of society and the economy. The electrochemical nitrogen reduction reaction (eNRR), especially when driven by renewable energy, is generally regarded as an energy-efficient and sustainable process to synthesize NH3 in ambient conditions. However, the performance of the electrocatalyst is far below expectations, with the lack of a high-efficiency catalyst being the main obstacle. Herein, by means of comprehensive spin-polarized density functional theory (DFT) computations, the catalytic performance of MoTM/C2N (TM = 3d transition metal) for use in eNRR was systematically evaluated. Among the results, MoFe/C2N can be considered the most promising catalyst due to its having the lowest limiting potential (−0.26 V) and high selectivity in the context of eNRR. Compared with its homonuclear counterparts, MoMo/C2N and FeFe/C2N, MoFe/C2N can balance the first protonation step and the sixth protonation step synergistically, showing outstanding activity regarding eNRR. Our work not only opens a new door to advancing sustainable NH3 production by tailoring the active sites of heteronuclear diatom catalysts but also promotes the design and production of novel low-cost and efficient nanocatalysts.
Stress‐strain characteristics of the Taipei silty clay at small strain

Abstract This study first developed a triaxial apparatus with the capability of small‐strain measurement. Then a series of undrained triaxial tests were carried out to investigate the stress‐strain behavior of the reconstituted Taipei silty clay at small strain. Test results show that the non‐linear behavior of the normally consolidated Taipei silty clay at small strain (ϵ=10–5∼10–3) is significant irrespective of the initial effective stress state and the shearing rate. The peak deviator stress occurs at strain of 10–3∼4×10–3. The normalized initial elastic stiffness at strain of 10–5 can reach 1600∼2450, which is much higher than that measured by conventional triaxial tests.
Prevalence and treatment patterns of adult atopic dermatitis in the UK Clinical Practice Research Datalink

Abstract The prevalence of active atopic dermatitis (AD) in adults in the UK according to disease severity shows variability. This study evaluated disease prevalence and treatment patterns among the adult UK population with AD. Data were obtained from the Clinical Practice Research Datalink (CPRD) database. Adults with active AD were identified by an AD‐related prescription or general practitioner visit within the same calendar year. Prevalence was defined as the number of patients with active AD on 1 January of each year as a percentage of the number of adults in the CPRD population on that date. Moderate‐to‐severe disease was classified as either referral to a specialist or prescription(s) for topical calcineurin inhibitors, phototherapy, or systemic treatment. Patient characteristics and treatment and referral patterns were analysed for patients with active AD in 2019. The overall prevalence of AD was stable at 2.4% per year during the period 2015–2019. In 2019, mean patient age (± standard deviation) was 52.6 ± 21.0 years, 58.2% of patients were female and mean disease duration was 9.4 ± 5.9 years. The most prescribed treatment was topical corticosteroids, in 78.5% of patients. 36.7% of patients with moderate‐to‐severe AD were prescribed systemic agents and 59.8% (vs. 32.3% of patients with mild AD) were referred to any secondary care or specialist treatment. The prevalence of active AD in the adult UK population was stable over the 5‐year period (2015–2019) and was comparable to estimates from similar studies based on UK primary healthcare records.
Feed Conversion Ratio (FCR) and Performance Group Estimation Based on Predicted Feed Intake for the Optimisation of Beef Production

This paper reports on the use of estimates of individual animal feed intake (made using time spent feeding measurements) to predict the Feed Conversion Ratio (FCR), a measure of the amount of feed consumed to produce 1 kg of body mass, for an individual animal. Reported research to date has evaluated the ability of statistical methods to predict daily feed intake based on measurements of time spent feeding measured using electronic feeding systems. The study collated data of the time spent eating for 80 beef animals over a 56-day period as the basis for the prediction of feed intake. A Support Vector Regression (SVR) model was trained to predict feed intake and the performance of the approach was quantified. Here, feed intake predictions are used to estimate individual FCR and use this information to categorise animals into three groups based on the estimated Feed Conversion Ratio value. Results provide evidence of the feasibility of utilising the ‘time spent eating’ data to estimate feed intake and in turn Feed Conversion Ratio (FCR), the latter providing insights that guide farmer decisions on the optimisation of production costs.
UBVI charge-coupled device photometry of two old open clusters NGC 1798 and 2192

We present UBVI charge-coupled device (CCD) photometry of two open clusters NGC 1798 and 2192, which have been little studied before. Colour--magnitude diagrams of these clusters show several features that are typical of old open clusters: a well-defined main sequence, a red giant clump, and a small number of red giants. The main sequence of NGC 1798 shows a distinct gap at V≈ 16.2 mag. From the surface number density distribution we have measured the size of the clusters, obtaining 8.3 arcmin (= 10.2 pc) for NGC 1798 and 7.3 arcmin (= 7.5 pc) for NGC 2192. Then we have determined the reddening, metallicity, and distance of these clusters using the colour--colour diagrams and colour--magnitude diagrams: E(B-V)=0.51 ± 0.04, [Fe/H] = -0.47 ± 0.15 dex and (m-M)0=13.1 ± 0.2 (d=4.2 ± 0.3 kpc) for NGC 1798, and E(B-V)=0.20 ± 0.03, [Fe/H] = -0.31 ± 0.15 dex and (m-M)0=12.7 ± 0.2 (d=3.5 ± 0.3 kpc) for NGC 2192. The ages of these clusters have been estimated using the morphological age indicators and the isochrone fitting with the Padova isochrones: 1.4 ± 0.2 Gyr for NGC 1798 and 1.1 ± 0.1 Gyr for NGC 2192. The luminosity functions of the main-sequence stars in these clusters are found to be similar to other old open clusters. The metallicity and distance of these clusters are consistent with the relation between the metallicity and the Galactocentric distance of other old open clusters.
Statistical spatial series modelling

A random spatial series is a collection of random variables F(xi , · · ·, xn ) depending on several spatial coordinates (x 1, · · ·, xn ). An attempt is made to construct a statistical second-order theory of such series when (x 1, · · ·, xn ) varies over a regular cartesian lattice. Using the properties of the linear (Hilbert) space associated with the series, the concepts of innovation and purely non-deterministic (p.n.d.) series are introduced. For a p.n. d. series F(x 1, · · ·, xn ) a unilateral representation is obtained in terms of a white innovations series Z(y 1, · · ·, yn ) where The representatation is specialized to the homogeneous case and we discuss spectral conditions for p.n. d. The familiar time-series condition ∫ log f(λ) dλ > –∞ on the spectral density f is necessary but not sufficient. A sufficient condition is stated. Motivated by the p.n. d. unilateral representation results we define unilateral arma (autoregressive-moving average) spatial series models. Stability and invertibility conditions are formulated in terms of the location of zero sets of polynomials relative to the unit polydisc in Cn , and a rigorous shift operator formalism is established. For autoregressive spatial series a Yule–Walker-type matrix equation is formulated and it is shown how this can be used to obtain estimates of the autoregressive parameters. It is demonstrated that under mild conditions the estimates are consistent and asymptotically normal.
Cerebral Circulation and Brain Temperature during an Ultra-Short Session of Dry Immersion in Young Subjects

The primary aim of the study was to assess cerebral circulation in healthy young subjects during an ultra-short (45 min) session of ground-based microgravity modeled by “dry” immersion (DI), with the help of a multifunctional Laser Doppler Flowmetry (LDF) analyzer. In addition, we tested a hypothesis that cerebral temperature would grow during a DI session. The supraorbital area of the forehead and forearm area were tested before, within, and after a DI session. Average perfusion, five oscillation ranges of the LDF spectrum, and brain temperature were assessed. Within a DI session, in the supraorbital area most of LDF parameters remained unchanged except for a 30% increase in respiratory associated (venular) rhythm. The temperature of the supraorbital area increased by up to 38.5 °C within the DI session. In the forearm area, the average value of perfusion and its nutritive component increased, presumably due to thermoregulation. In conclusion, the results suggest that a 45 min DI session does not exert a substantial effect on cerebral blood perfusion and systemic hemodynamics in young healthy subjects. Moderate signs of venous stasis were observed, and brain temperature increased during a DI session. These findings must be thoroughly validated in future studies because elevated brain temperature during a DI session can contribute to some reactions to DI.
Hubungan Kecenderungan Perilaku Narsistik dengan Penerimaan Diri Remaja Pengguna Media Sosial Instagram di SMAN 2 Kota Tasikmalaya

Background. : Narcissistic behavioral tendencies are self-loving behaviors and have a need to be adored or appreciated. The tendency of this narcissistic behavior can unwittingly affect the self-acceptance of a teenager. This study aims to determine the relationship between narcissistic behavior tendencies and self-acceptance in adolescents who use Instagram social media. Methods. The design of this research is correlational analysis and quantitative research approach cross sectional. Sampling using purposive sampling with research respondents totaling 93 respondents. The research instrument is a questionnaire that uses a Likert scale and uses an ordinal measuring scale. Bivariate analysis using Somers'd test. Results. The results of the univariate characteristics of the respondents obtained a median of 17 years and the majority were female as much as 63.4%. The majority of respondents had a tendency to narcissistic behavior in the less narcissistic category of 52.7% and high self-acceptance of 53.8%. The results of the correlation hypothesis obtained a p-value of 0.000 (P<0.05) and r=0.936. Conclusion. There is a negative relationship between narcissistic behavior tendencies and self-acceptance of social media users instagram with very strong power. The higher the tendency of narcissistic behavior, the lower the self-acceptance of adolescents who use social media instagram.