Miracle-dz/UniFAR-FTUs huggingface dataset:
A binary segmentation method for detecting topological domains in Hi-C data

: The three-dimensional (3D) architecture of chromosomes in nuclear space plays an important role in studying gene expression and regulation in cell biology. In particular, chromosome conformation capture (3C) techniques are used to study the spatial structure of chromosomes. Many such methods have been developed in the last two decades. Among them, Hi-C is a technology that uses a deep sequencing approach to detect the 3D spatial organization of a genome. That is, Hi-C allows us to evaluate spatial proximity between any pair of loci along the genome. This results in an interaction matrix with the frequency of interactions between genomic loci that physically interact in the nucleus. Highly self-interacting regions appear in the contact map of such interaction matrices. These regions are called topological domains and they play an important role in regulating gene expression and other genomic functions. Thus detecting such topological domains will provide new insights on chromosomal conformation in better understanding of cell functioning and various diseases. The topological domains centered along a diagonal region in contact maps are more likely to exist and prominent in data. In this study, we focus on detecting such domains, and we approach this problem as a two-dimensional segmentation problem. To solve this segmentation problem, we propose an algorithm based on the binary segmentation method, a well-known recursive partitioning technique used in change point detection problems. Our numerical experiments illustrate the usefulness of this approach. We obtain estimates for the number of diagonal blocks and their boundaries in an artificially generated data matrix and compare the re-sults of these estimates to those obtained with the HiCSeg R package. We conclude that binary segmentation method works well in identifying such domains with easy implementation and a low computational cost.
Gendered familialism in a Mediterranean context: women’s labor market participation and early childhood education and care in Turkey

Abstract This article explores the relationship between women’s labor market participation and early childhood education and care (ECEC) in Turkey within a broader Mediterranean context. Since the 1990s, there have been significant changes in the familialist models in the Mediterranean region driven by women’s increased labor market participation and the expansion of ECEC services. The transformations in the region have unveiled a significant link between the expansion of preschool education and an increase in women’s labor market participation. Turkey missed this critical juncture in the 1990s, as indicated by the low employment rates of women and below-the-Organisation for Economic Co-operation and Development (OECD)-average preschool enrolment. Through a comparative perspective that examines the slow progress in both areas in Turkey as well as the gendered feature of its familialist model, the article emphasizes the need for closer analysis of the link between ECEC and the low labor force participation of women. Given that the expansion of ECEC in the 2000s has taken place through market-driven services, the article concludes that the link between ECEC and women’s labor market participation exhibits a class dimension. Thereby, women from lower socio-economic groups are increasingly experiencing the impact of the gendered characteristics inherent in the familialist regime in Turkey.
Therapeutic landscapes : the dynamic between place and wellness

chapter 1 Introduction chapter 2 Rehabilitating Middle England: Integrating Ecology, Aesthetics, and Ethics chapter 3 Accessible Wilderness as a Therapeutic Landscape: Experiencing the Nature of Denali National Park, Alaska chapter 4 Summer Camp as a Therapeutic Landscape chapter 5 Place Identity and Therapeutic Landscapes: The Case of Home Care Workers in a Medically Underserviced Area chapter 6 Compromised Space: Contests over the Provision of a Therapeutic Environment for People with Mental Illness chapter 7 Mental Health and the Therapeutic Geographies of the City: Individual and Collective Negotiations chapter 8 The Street Gives and the Street Takes: Designing Housing for the Chronically Homeless chapter 9 Auckland's Starship Enterprise: Placing Metaphor in a Children's Hospital chapter 10 Healing Landscapes: Revolution and Health Care in Post-Socialist Havana chapter 11 Place, Space, and Geographies of Health Care: Historical and Contemporary Perspectives chapter 12 Index
Integration of Local Cultural Values in Forming Student Morale in Learning Islamic Religious Education in Junior High Schools

This study aims to analyze how local (Minangkabau) cultural integration forms in learning Islamic religious education, and its effect on the behavior of students in secondary schools. This study used a qualitative method with a case study approach, data were collected through in-depth interviews with ten informants consisting of school principals, Islamic religious education teachers, culture and arts teachers and students. All data were analyzed using the Miles and Huberman technique. The research findings show four forms of integration of local (Minangkabau) culture with the learning of Islamic religious education conducted by the school. The four integrations are (cultural learning through Islamic religious education subject matter, holding traditional dress days at school, shaping the daily behavior of students according to culture, holding extracurricular activities about cultural and customary teachings. Furthermore, the findings also found that the integration of local (Minangkabau) culture with Islamic religious education has an effect on the attitudes and behavior of students such as (ability to communicate well, growing attitudes of loving culture and customs, liking to dress in traditional clothes that are more polite and neat). This integration model can be used as a reference for other schools in teaching values culture and customs through learning Islamic religious education
The role of moving duck flocks in the spread of Highly Pathogenic Avian Influenza (HPAI) virus in Vietnam and Indonesia

Moving or nomadic duck flocks in SE-Asia are flocks that are frequently transported to areas where they can find suitable feed, in particular in rice paddies after the harvest. Using rapid rural appraisal methods we interviewed moving duck owners in the Mekong Delta of Viet Nam and in Central Java of Indonesia to describe their management system. The characteristics of the moving duck production system appear to be conducive to these ducks spreading and transmitting HPAI virus to other birds: 1) Flocks are moved frequently and quickly over large distances, 2) Flocks use many different scavenging areas, 3) Flocks are exposed to numerous HPAI risk factors, such as having contact with other scavenging ducks, wild birds and domestic animals, and 4) A large number of people are involved in transport and management of these flocks. In Viet Nam, movement of ducks is usually conducted with boats and trucks over long distances (median distance travelled per year: 80km) throughout most of the year (travel duration per year: 30-285 days), while in Indonesia flocks travel shorter distances during just a few months of the year and are transported on motorbikes, cars or herded by foot. Moving duck flocks in Viet Nam are larger than in Indonesia and are usually moved as single flocks owned by only one farmer, whereas in Indonesia, flocks of several owners often share transport. In additional field studies, 48 Vietnamese and 54 Indonesian moving duck flocks were monitored over a period of 6 months with blood samples being collected from individual birds. Overall crude bird-level HPAI H5 antibody prevalence (HI titre≥16) was about 15.5% in Viet Nam and 5.3% in Indonesia.
On plane wave and vortex-like solutions of noncommutative Maxwell-Chern-Simons theory

We investigate the spectrum of the gauge theory with Chern-Simons term on the noncommutative plane, a modification of the description of the Quantum Hall fluid recently proposed by Susskind. We find a series of the noncommutative massive ``plane wave'' solutions with polarization dependent on the magnitude of the wave-vector. The mass of each branch is fixed by the quantization condition imposed on the coefficient of the noncommutative Chern-Simons term. For the radially symmetric ansatz a vortex-like solution is found and investigated. We derive a nonlinear difference equation describing these solutions and we find their asymptotic form. These excitations should be relevant in describing the Quantum Hall transitions between plateaus and the end transition to the Hall Insulator.
Sub-Scalp Implantable Telemetric EEG (SITE) for the Management of Neurological and Behavioral Disorders beyond Epilepsy

Sub-scalp Implantable Telemetric EEG (SITE) devices are under development for the treatment of epilepsy. However, beyond epilepsy, continuous EEG analysis could revolutionize the management of patients suffering from all types of brain disorders. This article reviews decades of foundational EEG research, collected from short-term routine EEG studies of common neurological and behavioral disorders, that may guide future SITE management and research. Established quantitative EEG methods, like spectral EEG power density calculation combined with state-of-the-art machine learning techniques applied to SITE data, can identify new EEG biomarkers of neurological disease. From distinguishing syncopal events from seizures to predicting the risk of dementia, SITE-derived EEG biomarkers can provide clinicians with real-time information about diagnosis, treatment response, and disease progression.
The Effect of Couple Card Media on Elementary School Students’ Science Learning Outcomes in Class IV MIN 8 Medan City

The reason for conducting research is based on several problems in the form of teaching activities whose center is still on the teacher (teacher centered), on the other hand the students' learning outcomes are still low and the teaching process has not been able to fully improve student outcomes in their learning. The aim of the research is to find out the effect of Couple Card media on Elementary School Students’ Science Learning Outcomes in Class IV MIN 8 Medan City. The research method used was in the form of an experiment through a quasi-experimental design in the form of a nonequivalent control group, which acted as research subjects, consisting of 40 students of class IV. In analyzing the data, the researcher conducted a normality test accompanied by the Wilcoxon test due to not normally data distribution. Based on the Wilcoxon signed rank results, it can be seen that Asymp.Sig. (2-tailed) has a value of 0.001. Because the value of 0.000 is smaller than 0.05 (0.000 < 0.05) it is understood that there are differences in learning outcomes with these differences being significant both in the pretest and post-test when learning is not carried out using couple card media. Through the use of media in the form of couple cards it is known that there is an influence on the learning outcomes passed by students so that it was concluded that the media in the form of couple cards provided an increase in student results in their learning.
An assessment of the shore-based and offshore boat-based linefisheries of KwaZulu-Natal, South Africa.

ii PREFACE iv DECLARATIONPLAGIARISM v TABLE OF CONTENTS vi ACKNOWLEDGMENTS ix CHAPTER 1: INTRODUCTION 1 1.1. Rationale 1 1.2. Development of linefish management in KwaZulu-Natal 4 1.3. Study Area 12 1.3. Statistical analysis 15 CHAPTER 2: CATCH AND EFFORT OF THE KWAZULU-NATAL SHORE LINEFISHERY 17 2.
Cyprus Before History: From the Earliest Settlers to the End of the Bronze Age

Cyprus is the third largest island in the Mediterranean, and lies at the nexus of many important ancient trade routes, from Asia Minor to Africa, from Persia, Assyria and other great eastern powers to Italy and Greece. In antiquity the island was famed for its great wealth, not only from trade but also from its natural resources of copper as well as wine and olive oil. Recent excavations in Cyprus have radically altered our understanding of the earliest prehistory of the island. In this new appraisal Louise Steel explores the archaeological evidence for human occupation on Cyprus from the earliest hunter-gatherers and the first farming communities to the end of the Bronze Age. She examines major issues that dominate current research on Cypriot prehistory: island colonisation; population migrations; the interpretation of figured art; the emergence of social complexity; and the shift from isolation in earlier prehistory to a position at the centre of Mediterranean trade. "Cyprus Before History" presents a social history of ancient Cyprus, exploring ways of life and death, changing farming practices and diet, social customs, early belief systems, and interaction with the Cypriot landscape and the wider Mediterranean.
Relationship between fixed capital formation and carbon emissions: Impact of trade liberalization in India

Abstract The liberalization of economies is aimed at boosting domestic growth through foreign investment and trade. The proponents of liberalization argue that opening up markets in developing economies provides access to capital to enhance production. However, proponents of the pollution haven hypothesis (PHH) argue that liberalization and trade agreements have led to the export of carbon-intensive production from wealthier countries to developing economies. The difference between the two outcomes lies in the nature of fixed assets built by developing countries. In this study, we examine the role of fixed capital formation on carbon emissions during two distinct periods of India’s economic development. India liberalized its economy with trade reforms in 1991, thereby providing two distinct time periods of closed and open trade policies. The economic data during 1971–2021 is divided into two parts—before (1971–1990) and after (1991–2021) liberalization. Gross fixed capital formation (GFCF) is used as a measure of capital formation while carbon emissions are used to represent environmental impact. Auto-regressive distributed lag (ARDL) model is used for analysis. Results indicate that GFCF had no significant relationship with carbon emission before liberalization, whereas, there was a significant, positive impact post-liberalization. The study is of significance to policymakers in developing countries as it suggests a change in the capital formation towards low carbon-intensive products and services. It also strengthens the argument for investing capital in cleaner energy and technologies.
Bigels as novel systems for the delivery active compounds from Centella asiatica

ABSTRACT Cosmetic products containing ingredients derived from Centella asiatica show antioxidant, anti-inflammatory and anti-aging effects. To increase the activity of C. asiatica extracts, we developed and checked the multidirectional action of the Centella asiatica extract and macerated oil after introducing it into the physicochemical form, which is bigel. Bigels were prepared by mixing oleogels and hydrogels in different mass ratio. The obtained formulations were analyzed microscopically, for pH, rheological properties, antioxidant capacity, antimicrobial activity. In addition, sensory analysis and instrumental test were performed. Only bigels with a mass ratio hydrogel to oleogel 9:1 were stable and had a correspondingly smooth, creamy consistency. The addition of C. asiatica extract to the recipe had a positive effect on the ability of the preparation to scavenge free radicals, while the addition macerate had negative effect for this ability. The highest increase in skin hydration, and in the mean value of skin smoothing was shown by preparation B3 containing the extract from C. asiatica. Proven properties such as antioxidant capacity, moisturizing, improvement of skin smoothness, and reduction of discoloration indicate the potential of using these preparations in anti-aging, moisturizing cosmetics, which has so far been demonstrated only for physiochemical forms such as emulsion and hydrogels. GRAPHICAL ABSTRACT
Quantification of spinal ataxia in dogs with thoracolumbar spinal cord injury

The clinical sign of ataxia is related to several neurological diseases and is seen in conjunction with paresis in dogs with spinal cord injury (SCI). Endeavours to objectify canine spinal ataxia in SCI remain limited. The aim of this clinical study was to determine and quantify differences between gait characteristics of ataxic dogs with thoracolumbar myelopathy and healthy control dogs using a computer-and treadmill-based gait analysis system. Five dogs with spinal ataxia and six healthy dogs underwent video-and computer-assisted gait analysis while walking on a four-ground reaction force plate treadmill system (maximum speed of 0.7 m/s). Spatio-temporal and kinetic gait characteristics regarding the dogs’ locomotion were analysed with a focus on the individual coefficient of variation (CV), as a potential measure for quantification of the level of ataxia. Ataxic dogs with thoracolumbar SCI showed no effect on symmetry indices but higher variability in spatio-temporal and kinetic gait parameters mainly in the pelvic, but also in the thoracic limbs. Double support phase of the individual limb was prolonged in SCI dogs at the cost of the single support and swing phase. Reduced peaks of ground reaction forces (GRF) could potentially be explained by reduction of muscle strength, as a strategy of avoiding falling by taking enthusiastic steps, or by alteration of the rhythmogenic spinal circuits between the pelvic and thoracic limb pattern generators.
Improved pregnancy rate and sex ratio in fresh/frozen in vivo derived embryo transfer of Hanwoo (Bos taurus coreanae) cows

Abstract This study aimed to assess the effects of embryonic developmental stage, quality grade, and fresh or frozen/thawed conditions on the pregnancy rate and sex ratio of live offspring in Hanwoo (Bos taurus coreanae) cows. The quality and developmental stage of in vivo-derived (IVD) transferred embryos were evaluated using the standard criteria of the International Embryo Technology Society. The recipient cows were synchronized using conventional (estradiol benzoate and progesterone) protocols before embryo transfer. Embryos were transferred to 297 cows, and pregnancy was monitored for 60–70 days after embryo transfer. The pregnancy rates of fresh and frozen/thawed embryos were 56.90% and 52.49%, respectively. Pregnancy rates varied according to embryo quality (56.18% for grade 1 vs. 36.67% for grade 2). Pregnancy rates also varied by developmental stage and cryopreservation (67.86% vs. 63.49% for stage 4-1, 64.00% vs. 54.72% for 5-1, and 50.00% vs. 47.83% for 6-1, in fresh embryos vs. frozen/thawed embryos, respectively). For stage 7-1, the pregnancy rates were 72.73% for fresh embryos and 20.00% for frozen/thawed embryos. In 66 fresh embryos, the sex ratio of live offspring was 5:5, whereas it was 4(female):6(male) for frozen/thawed embryos among the 95 frozen/thawed embryos. The miscarriage rate was approximately 3% higher for frozen/thawed embryos than for fresh embryos (18.1% for fresh vs. 21.1% for frozen). Seasonal fertility rates were 33.3% in spring, 55.67% in summer, 52.8% in autumn, 60.0% in winter. The following male-to-female ratios were observed in different seasons: 6.7:3.3 in spring, 4.0:6.0 in summer, 5.5:4.5 in autumn, and 3.3:6.7 in winter. The current data revealed no significant differences in pregnancy rates between fresh and frozen/thawed IVD embryos. However, there was a lower pregnancy rate with advanced-stage frozen/thawed embryos (stage 7-1). The current study provides comprehensive results for the better optimization of embryo transfer in Hanwoo cattle to obtain the desired fertility rate, pregnancy rate, and sex ratio of calves. These results provide important insights into the factors that influence the viability and success of IVD embryo transfer in Hanwoo cows and may have practical applications for improving breeding programs and reducing production costs.
Personal valuation of Chinese language for social functions among senior high school learners

In recent decades, the Chinese language experienced an increase in educational demand, which calls the academic institutions to integrate basic Chinese language subjects into their curriculum. The spike in Chinese language use resulted in the expansion of language studies focusing on Chinese as a second and foreign language. Given the broad scope of research in Chinese language learning, there was a need to expand the understanding of the personal valuation of the learners in learning the Chinese language. Hence, this study aimed to assess the extent of the subjective valuation of Filipino students in the Chinese language, particularly for social functions. An exploratory approach was carried out to extract narrative data from the study participants. Eight secondary students were interviewed on the personal valuation of the Chinese language within social functions. The findings demonstrated that the Chinese language was commonly used within social instances for specific sociocultural and psycholinguistic patterns. The participants valued the use of the Chinese language because of its instrumentality in their future careers; it enabled them to be culturally sensitive and engaged in sociocultural communication. Theoretical analysis also highlighted that language socialization became a major driving force in language learning. Language socialization encompassed learning beyond academic purposes while underscoring the need for social interaction and interpersonal orientation. Nevertheless, personal valuations reflected learners’ beliefs towards the instrumentality of the Chinese language, especially in social functions.
Craniodental morphology of genus Homo (Africa and Asia)

Preface to Volumes One and Two. PART 1. INTRODUCTION. Descriptive Protocol. Descriptive Format. Anatomical Terminology Figures. Abbreviations. Maps. Layout of Entries. PART 2A. AFRICA. Bodo. Border Cave. Boskop. Cave of Hearths. Chemeron. Dar es Soltane II. Eilye Springs. Eyasi. Fish Hoek. Florisbad. Guomde. Hadar. Haua Fteah. Jebel Irhoud. Kabwe. Klasies River Mouth. Koobi Fora. Laetoli (Ngaloba). Melka Kontoure. Nariokotome. Ndutu. Olduvai Gorge. Omo Kibish. Saldanha. Sale. Singa. Sterkfontein. Swartkrans. Thomas Quarry. Tighenif. Tuinplaas. Uraha. PART 2B. ASIA, WESTERN. Amud. Jebel Qafzeh. Kebara. Shanidar. Skhul. Tabun. Teshik-Tash. Zuttiyeh. PART 2C. ASIA, EASTERN, AND CENTRAL. Dali. Hexian. Jinniushan. Kedungbrubus. Lantian. Liujiang. Longgupo. Maba. Mojokerto. Narmada. Ngandong. Ngawi. Sambungmachan. Sangiran. Trinil. Wajak. Yuanmou. Yunxian. Zhoukoudian Lower Cave. Zhoukoudian Upper-Cave. PART 3. FOSSILS ATTRIBUTED TO GENUS HOMO: SOME GENERAL NOTES. "Early Homo". Homo erectus and Its Putative Relatives in Africa and Asia. Extinct European Homo and Putative Relatives. Homo sapiens and "Archaic Homo sapiens". Conclusion.