Miracle-dz/UniFAR-FTUs huggingface dataset:
Global and national influenza-associated hospitalisation rates: Estimates for 40 countries and administrative regions

Background WHO estimates that seasonal influenza epidemics result in three to five million cases of severe illness (hospitalisations) every year. We aimed to improve the understanding of influenza-associated hospitalisation estimates at a national and global level. Methods We performed a systematic literature review of English- and Chinese-language studies published between 1995 and 2020 estimating influenza-associated hospitalisation. We included a total of 127 studies (seven in Chinese) in the meta-analysis and analyzed their data using a logit-logistic regression model to understand the influence of five study factors and produce national and global estimates by age groups. The five study factors assessed were: 1) the method used to calculate the influenza-associated hospitalisation estimates (rate- or time series regression-based), 2) the outcome measure (divided into three envelopes: narrow, medium, or wide), 3) whether every case was laboratory-confirmed or not, 4) whether the estimates were national or sub-national, 5) whether the rates were based on a single year or multiple years. Results The overall pooled influenza-associated hospitalisation rate was 40.5 (95% confidence interval (CI) = 24.3-67.4) per 100 000 persons, with rates varying substantially by age: 224.0 (95% CI = 118.8-420.0) in children aged 0-4 years and 96.8 (95% CI = 57.0-164.3) in the elderly aged >65 years. The overall pooled hospitalisation rates varied by calculation method; for all ages, the rates were significantly higher when they were based on rate-based methods or calculated on a single season and significantly lower when cases were laboratory-confirmed. The national hospitalisation rates (all ages) varied considerably, ranging from 11.7 (95% CI = 3.8-36.3) per 100 000 in New Zealand to 122.1 (95% CI = 41.5-358.4) per 100 000 in India (all age estimates). Conclusions Using the pooled global influenza-associated hospitalisation rate, we estimate that seasonal influenza epidemics result in 3.2 million cases of severe illness (hospitalisations) per annum. More extensive analyses are required to assess the influence of other factors on the estimates (e.g. vaccination and dominant virus (sub)types) and efforts to harmonize the methods should be encouraged. Our study highlights the high rates of influenza-associated hospitalisations in children aged 0-4 years and the elderly aged 65+ years.
Improvements in disability and function in people with lower-limb amputation one year after prosthesis osseointegration

Background: People with lower-limb amputation (LLA) are routinely prescribed a socket prosthesis; however, many socket prosthesis users experience severe complications with the fit of their prosthesis including residual limb wounds and pain. Osseointegration is a procedure that creates a direct connection between the bone and prosthetic limb through a bone-anchored prosthesis, eliminating the need for a socket interface. It is offered as a secondary procedure to people with LLA who experience significant complications with socket prostheses. Objectives: To evaluate change in disability and function 1 year postosseointegration compared with preosseointegration in people with LLA. Study design: Single group, pretest, and post-test. Methods: Twelve participants (9 transfemoral and 3 transtibial amputations, age: 44 ± 10 years, 7 female participants, 14 ± 12 years since amputation) with unilateral LLA underwent osseointegration with press-fit implants. Disability was measured with the World Health Organization Disability Assessment Schedule 2.0, and function was measured with both Prosthetic Limb Users Mobility Survey and the Activities-Specific Balance Confidence Scale. Questionnaires were administered preosseointegration and 1 year postosseointegration. Paired t tests assessed change in outcomes between time points. Results: Postosseointegration, participants demonstrated reduced disability measured with World Health Organization Disability Assessment Schedule 2.0 (%Δ = −52.6, p = 0.01), improved mobility measured with Prosthetic Limb Users Mobility Survey (%Δ = 21.8, P < 0.01), and improved balance confidence measured with the Activities-Specific Balance Confidence Scale (%Δ = 28.4, P < 0.01). Conclusions: Participants report less disability and greater function in their prosthesis postosseointegration. Osseointegration is a novel procedure for people experiencing complications with their socket prosthesis, and this study is the first to show improvements in disability postosseointegration.
On the Poincaré Problem

Abstract We derive some restrictions on the possible degrees of algebraic invariant curves and on the possible form of algebraic integrating factors, for plane polynomial vector fields whose stationary points at infinity satisfy a certain genericity condition. The method is elementary, and we show by example that it also yields strong results for certain non-generic vector fields.
Similar Presynaptic Action Potential-Calcium Influx Coupling in Two Types of Large Mossy Fiber Terminals Innervating CA3 Pyramidal Cells and Hilar Mossy Cells

Abstract Morphologically similar axon boutons form synaptic contacts with diverse types of postsynaptic cells. However, it is less known to what extent the local axonal excitability, presynaptic action potentials (APs), and AP-evoked calcium influx contribute to the functional diversity of synapses and neuronal activity. This is particularly interesting in synapses that contact cell types that show only subtle cellular differences but fulfill completely different physiological functions. Here, we tested these questions in two synapses that are formed by rat hippocampal granule cells (GCs) onto hilar mossy cells (MCs) and CA3 pyramidal cells, which albeit share several morphologic and synaptic properties but contribute to distinct physiological functions. We were interested in the deterministic steps of the action potential-calcium ion influx coupling as these complex modules may underlie the functional segregation between and within the two cell types. Our systematic comparison using direct axonal recordings showed that AP shapes, Ca2+ currents and their plasticity are indistinguishable in synapses onto these two cell types. These suggest that the complete module that couples granule cell activity to synaptic release is shared by hilar mossy cells and CA3 pyramidal cells. Thus, our findings present an outstanding example for the modular composition of distinct cell types, by which cells employ different components only for those functions that are deterministic for their specialized functions, while many of their main properties are shared.
Harm Avoidance is Correlated with the Reward System in Adult Patients with Attention Deficit Hyperactivity Disorder: A Functional Magnetic Resonance Imaging Study

Objective Hypoactivity in the reward system among patients with attention deficit hyperactivity disorder (ADHD) is a well-known phenomenon. Whether the activity in the reward pathway is related to harm avoidance, such as in sensitivity to punishment, is unclear. Evidence regarding the potential difference between ADHD patients and controls in terms of this association is scarce. Methods Event-related functional magnetic resonance imaging was conducted on subjects performing the Iowa gambling test. Fourteen adults with ADHD and 14 controls were enrolled in the study. Results Harm avoidance was found to be positively correlated with the activities of the bilateral orbitofrontal cortex and right insula in individuals with ADHD. A group difference was also confirmed. Conclusion Understanding the roles of harm avoidance and brain activation during risk tasks is important.
Mammalian forelimb evolution is driven by uneven proximal-to-distal morphological diversity

Vertebrate limb morphology often reflects the environment due to variation in locomotor requirements. However, proximal and distal limb segments may evolve differently from one another, reflecting an anatomical gradient of functional specialization that has been suggested to be impacted by the timing of development. Here, we explore whether the temporal sequence of bone condensation predicts variation in the capacity of evolution to generate morphological diversity in proximal and distal forelimb segments across more than 600 species of mammals. Distal elements not only exhibit greater shape diversity, but also show stronger within-element integration and, on average, faster evolutionary responses than intermediate and upper limb segments. Results are consistent with the hypothesis that late developing distal bones display greater morphological variation than more proximal limb elements. However, the higher integration observed within the autopod deviates from such developmental predictions, suggesting that functional specialization plays an important role in driving within-element covariation. Proximal and distal limb segments also show different macroevolutionary patterns, albeit not showing a perfect proximo-distal gradient. The high disparity of the mammalian autopod, reported here, is consistent with the higher potential of development to generate variation in more distal limb structures, as well as functional specialization of the distal elements.
Airborne transmission of SARS‐Cov2: What consequences for digestive endoscopy?

Abstract The SARS‐Cov‐2 disease disrupted essential hospital procedures, such as gastrointestinal (GI) endoscopy, due to concerns about air transmission and the risk of exposing health care workers. With the spread of the pandemic, air transmission was considered as the main source of SARS‐Cov2 transmission. This raised the problem of transmission by aerosolization of viral particles in operating rooms as well as endoscopy units. This is in line with the known airborne transmission of many other respiratory viruses. The risk of SARS‐Cov‐2 transmission during GI endoscopy was initially reduced by controlled measures, involving personal protections (mask…), restricted access to endoscopy rooms, and detection of infected patients. Gastrointestinal endoscopy generates aerosols, which may carry viruses. In addition, the endoscopy system may facilitate the diffusion of virus particles or fomites considering the forced‐air cooling system used to maintain a stable temperature inside the box (25°C). The volume of air that goes through the light source box is high (240–300 m3 for a 1‐h period). Moreover, the light system contains an air pump to inflate air inside the gut lumen. In order to isolate people from hazard, different levels of protection and solutions to avoid airborne transmission of microorganisms should be proposed, such as the reinforcement of personal protective equipment, the change in the way people work and engineering control of the risk.
A study on tuberculosis disease disclosure patterns and its associated factors: Findings from a prospective observational study in Chennai

Background Disclosure of tuberculosis (TB) status by patients is a critical step in their treatment cascade of care. There is a lack of systematic assessment of TB disclosure patterns and its positive outcomes which happens dynamically over the disease period of individual patients with their family and wider social network relations. Methods This prospective observational study was conducted in Chennai Corporation treatment units during 2019–2021. TB patients were recruited and followed-up from treatment initiation to completion. Information on disease disclosures made to different social members at different time points, and outcomes were collected and compared. Bivariate and multi variate analysis were used to identify the patients and contact characteristics predictive of TB disclosure status. Results A total of 466 TB patients were followed-up, who listed a total of 4039 family, extra familial and social network contacts of them. Maximum disclosures were made with family members (93%) and half of the relatives, occupational contacts and friendship contacts (44–58%) were disclosed within 15 days of treatment initiation. Incremental disclosures made during the 150–180 days of treatment were highest among neighbourhood contacts (12%), and was significantly different between treatment initiation and completion period. Middle aged TB patients (31 years and 46–55 years) were found less likely to disclose (AOR 0.56 and 0.46 respectively; p<0.05) and illiterates were found more likely to disclose their TB status (AOR 3.91; p<0.05). Post the disclosure, family contacts have mostly provided resource support (44.90%) and two third of all disclosed contacts have provided emotional support for TB patients (>71%). Conclusion Findings explain that family level disclosures were predominant and disclosures made to extra familial network contacts significantly increased during the latter part of treatment. Emotional support was predominantly received by TB patients from all their contacts post disclosure. Findings could inform in developing interventions to facilitate disclosure of disease status in a beneficial way for TB patients.
Effects of the menstrual cycle phase on anterior cruciate ligament neuromuscular and biomechanical injury risk surrogates in eumenorrheic and naturally menstruating women: A systematic review

Background Eumenorrheic women experience cyclic variations in sex hormones attributed to the menstrual cycle (MC) which can impact anterior cruciate ligament (ACL) properties, knee laxity, and neuromuscular function. This systematic review aimed to examine the effects of the MC on ACL neuromuscular and biomechanical injury risk surrogates during dynamic tasks, to establish whether a particular MC phase predisposes women to greater ACL injury risk. Methods PubMed, Medline, SPORTDiscus, and Web of Science were searched (May-July 2021) for studies that investigated the effects of the MC on ACL neuromuscular and biomechanical injury risk surrogates. Inclusion criteria were: 1) injury-free women (18–40 years); 2) verified MC phases via biochemical analysis and/or ovulation kits; 3) examined neuromuscular and/or biomechanical injury risk surrogates during dynamic tasks; 4) compared ≥1 outcome measure across ≥2 defined MC phases. Results Seven of 418 articles were included. Four studies reported no significant differences in ACL injury risk surrogates between MC phases. Two studies showed evidence the mid-luteal phase may predispose women to greater risk of non-contact ACL injury. Three studies reported knee laxity fluctuated across the MC; two of which demonstrated MC attributed changes in knee laxity were associated with changes in knee joint loading (KJL). Study quality (Modified Downs and Black Checklist score: 7–9) and quality of evidence were low to very low (Grading of Recommendations Assessment Development and Evaluation: very low). Conclusion It is inconclusive whether a particular MC phase predisposes women to greater non-contact ACL injury risk based on neuromuscular and biomechanical surrogates. Practitioners should be cautious manipulating their physical preparation, injury mitigation, and screening practises based on current evidence. Although variable (i.e., magnitude and direction), MC attributed changes in knee laxity were associated with changes in potentially hazardous KJLs. Monitoring knee laxity could therefore be a viable strategy to infer possible ACL injury risk.
Radiation belt dynamics during solar minimum

Two types of temporal variation in the radiation belts are studied using low-altitude data taken onboard the DMSP F7 satellite: those associated with the solar cycle and those associated with large magnetic storm effects. Over a three-year period from 1984 to 1987 and encompassing solar minimum, the protons in the heart of the inner belt increased at a rate of approximately 6% per hear. Over the same period, outer zone electron enhancements declined both in number and peak intensity. During the large magnetic storm of February 1986, following the period of peak ring current intensity, a second proton belt with energies up to 50 MeV was found at magnetic latitudes between 45 degrees and 55 degrees . The belt lasted for more than 100 days. The slot region between the inner and outer electron belts collapsed by the merging of the two populations and did not reform for 40 days. >
Endurance degradation mechanisms in TiN\Ta2O5\Ta resistive random-access memory cells

Impact of set/reset pulse duration and amplitude on the endurance failure modes of TiN\Ta2O5\Ta cells is investigated and is related to interaction between Oxygen and TiN bottom electrode during reset. Hourglass electrical switching simulation of conductive filament temperature during reset transient and ab-initio calculation of reaction energy further support this degradation mechanism. Based on this understanding, endurance improvement is achieved by using shorter reset pulse and/or using inert Ru bottom electrode.
Scoping review of cytolytic vaginosis literature

Background Cytolytic vaginosis (CV) is a little-known, controversial condition that is typically not considered for women presenting with vulvovaginitis symptoms. Objective: The objective of this scoping review was to identify and compile the global evidence on CV. Methods A medical librarian searched Prospero, Wiley Cochrane Library, Ovid Embase, Ovid Medline, EBSCO CINAHL, ProQuest Dissertations and Theses Global, and Scopus, from inception to April 4, 2019 and updated to October 17, 2021. Studies were eligible if they discussed CV. Two independent reviewers conducted study selection and data extraction. Results Sixty-four studies were identified, with 67% of studies (n = 43) published since 2007. Studies were from around the world, including the United States (28%, n = 18), Brazil (11%, n = 7), Portugal (11%, n = 7), and China (11%, n = 7). Fifty percent of studies (n = 32) were reviews; the remainder were observational; and of these, 78% (n = 25) were cross-sectional. The most frequent topics included: diagnosis (19%, n = 12), prevalence (17%, n = 11), and overview of CV (50%, n = 32). Evidence for prevalence in symptomatic women (median prevalence of 5%, interquartile range 3%-8%) was based only on 16% of studies (n = 10) with minimal evidence on prevalence in asymptomatic women and across different geographic regions. Microbiological findings, including abundant lactobacilli and fragmented epithelial cells, were found useful to distinguish between CV and vulvovaginal candidiasis, and Lactobacillus crispatus was noted to dominate the vaginal flora in women with CV. Most studies used subjective criteria to diagnose CV as the condition lacks gold-standard microscopic criteria. The suggested primary treatment (baking soda irrigations) was largely based on expert opinion, and there was minimal evidence on associations between CV and other conditions. Conclusion Knowledge gaps currently exist in all realms of CV research. Additional research is needed to confirm the validity of CV and ensure that women are diagnosed and treated effectively.
Impact of updated trial data on the cost-effectiveness of percutaneous mitral repair

When updated clinical trial data becomes available reassessing the cost-effectiveness of technologies may modify estimates and influence decision-making. We investigated the impact of updated trial outcomes on the cost-effectiveness of percutaneous mitral repair (PR) for secondary mitral regurgitation. We updated our previous three-state time-varying Markov model to assess the cost-effectiveness of PR + guideline directed medical treatment (GDMT) versus GDMT alone. Key clinical inputs (overall survival (OS) and heart failure hospitalisations (HFH)) were obtained using the 3-year trial findings from the COAPT (Cardiovascular Outcomes Assessment of the MitraClip Percutaneous Therapy) RCT. We calculated incremental cost-effectiveness ratios (ICER) and report how these differ between analyses based on early (2-year) and updated (3-year) evidence. Updated trial data showed an increase in mortality in the intervention arm between two and three years follow-up that was not seen in the control arm. Deterministic and multivariate cost-effectiveness modelling yielded incremental cost effectiveness ratios ICERs of €38,123 and €31,227 /QALY. Compared to our 2-year based estimate (€21,918 / QALY) these results imply an approximate 1.5-fold increase in ICER. The availability of updated survival analyses from the COAPT pivotal trial suggests previous estimates based on 2-year trial findings were over optimistic for the intervention.
A Dynamical Core for Topological Directed Graphs

A topological graph, or quiver, is a directed graph where the edge and vertex spaces are topological spaces. The C*-algebra associated with the graph is a Cuntz-Pimsner algebra of an associated C*-correspondence over an abelian C*-algebra. For a given graph satisfying a properness hypothesis we construct and abstractly characterize a subgraph con- taining the iterative dynamical core of the original graph. The C*-algebra of this subgraph is a quotient of the C*-algebra of the graph, and under some additional assumptions is a crossed product C*-algebra by a shift endomorphism. This is accomplished using a compo- sition product of topological graphs.
Far Ultraviolet Spectroscopic Explorer ($\it FUSE$) observations of emitting and absorbing gas in the Local Interstellar Chimney

We present Far Ultraviolet Spectroscopic Explorer ($\it FUSE$) satellite measurements of the absorption and emission characteristics of interstellar gas associated with the Local Interstellar Chimney, which is an extension of the rarefied Local Bubble cavity that extends outward from the galactic disk towards the lower galactic halo. Far ultraviolet (FUV) diffuse background emission has been detected in the high ionization line of O VI ( λ 1032 A) for two lines-of-sight ($l = 162.7^{\circ}$, $b = +57.0^{\circ}$) and ($l = 156.3^{\circ}$, $b = +57.8^{\circ}$) at emission levels of $2500\pm700$ photons cm -2 s -1 sr -1 (LU) and $3300\pm1100$ LU respectively. These levels of O VI emission are very similar to those found for four other lines-of-sight sampled thus far by the $\it FUSE$ satellite, implying a fairly constant level of average O VI surface brightness emission at high galactic latitudes of about 2700 LU with a standard deviation of 450 LU. These emission-line data are supplemented by FUV interstellar absorption line measurements taken towards the hot DA white dwarf star, REJ 1032+532 ($l = 157.5^{\circ}$, $ b = +53.2^{\circ}$), whose distance of 116 pc places it within the Local Bubble region. No high ionization interstellar O VI λ 1032 A absorption has been detected $(N({\rm O~VI}) -2 ), which is consistent with the non-detections of interstellar C IV and Si IV absorption reported towards this star by Holberg et al. ([CITE]). Taken together, our FUV absorption and emission data may be explained by a scenario in which the O VI emission and absorption lines are $\it both$ formed at the conductive interface of the neutral boundary to the Local Bubble. For the presently sampled sight-lines we have found no correlation between the OVI emission line intensity and the associated 0.25 keV soft X-ray background flux as measured in the R1 and R2 bands by the $\it ROSAT$ satellite. The OVI line intensities also show no correlation with the soft X-ray background flux attributable to emission from the million degree K gas of the Local Hot Bubble as modeled by Kuntz & Snowden ([CITE]). Any (new) model of the Local Bubble must now be able to explain (i) the low levels of variability in both the O VI emission-line intensity and the associated soft X-ray background flux for galactic sight-lines > $|40|$°, (ii) the observed pressure of $P/k\sim 10\,000$ cm -3 K for the local hot interstellar gas, and (iii) the paucity of high ionization absorption lines observed within the local ISM and the sudden increase in their measured column density for distances beyond the Local Bubble neutral boundary.