Miracle-dz/UniFAR-FTUs huggingface dataset:
Mesenchymal stem cells promote infiltration of myeloid-derived suppressor cells after acute myocardial infarction via up-regulation of multiple cytokines

: Mesenchymal stem cell (MSC) therapy improves cardiac function after myocardial infarction (MI) in part via immune modulation. Myeloid-derived suppressor cells (MDSCs), defined as cells expressing the myeloid lineage markers cluster of differentiation CD11b and granulocyte-differentiation antigen Gr-1, are presumed to be recruited to sites of inflammation. However, it is not known whether the beneficial effects of MSC therapy for MI treatment are mediated by infiltrated MDSCs in infarcted hearts. Bone marrow-derived MSCs were injected into the peri-ischemic region of the myocardium after ligation of the proximal left coronary artery in a mouse model of MI. On days 1, 3, and 7, MDSC populations in blood and infarcted myocardium were examined by flow cytometry. At 1 day after MI, the number of CD11b + Gr-1 + MDSCs was increased in the ischemic myocardium of MSC-injected as compared to saline-injected mice (P < 0.001), whereas no differences were observed between the two groups on days 3 and 7. Histological analysis confirmed that MDSC recruitment to the myocardium was higher in the MSC-injected group than in the control group 1 day after MI. MSC treatment increased mRNA levels of chemokine (C-C motif) ligand 2 (CCL2), C-X-C motif chemokine (CXCL5) macrophage colony-stimulating factor (M-CSF), and cyclooxygenase 2 (COX2) in infarcted hearts. These results indicate that MSC treatment increases MDSC infiltration into the infarcted heart in the early period after MI via modulation of CCL2, CXCL5, M-CSF, and COX2 expression.
Conservation biology of bottlenose dolphins in Fiordland, New Zealand

The bottlenose dolphins of Fiordland, New Zealand, live at the southern limit of the species’ worldwide range. They are exposed to impacts from tourism and habitat modification, particularly in Doubtful Sound, and their conservation requirements are presently unclear. Dolphin abundance was estimated in Doubtful Sound using photoidentification census and capture-recapture techniques (56 individuals; 95% CI: 5557), detecting a decline of 34-39% over 12 years among adults and sub-adults (>3 years old). The cause of this decline was investigated via demographic modelling in Doubtful Sound and a comparative assessment of population status in Dusky Sound. Capture-recapture modelling of photo-identification data compiled since 1990 yielded a constant adult survival rate marginally lower than prior estimates for wild bottlenose dolphins (! a(1990–2008) = 0.9374; 95% CI: 0.9170-0.9530). Survival of calves (<1 year old) declined to an unsustainable level that is thought to be the lowest recorded for wild bottlenose dolphins (! c(2002–2008) = 0.3750; 95% CI: 0.2080-0.5782) coincident with the opening of a second tailrace tunnel for a hydroelectric power station. Reverse-time capture-recapture modelling detected declines in recruitment (f(1994–2008) = 0.0249; 95% CI: 0.0174-0.0324) and population growth (! (1994–2008) = 0.9650; 95% CI: 0.95540. 9746) over time consistent with the decline in calf survival (<1 year old) and a separate reduction in juvenile survival (1 to 3 years old) reflecting cumulative impacts. Dolphin abundance was estimated in Dusky Sound using photo-identification census and capture-recapture techniques (102 individuals; 95% CI: 100-104) providing no evidence of interchange with Doubtful Sound. A comparative assessment of health status between Doubtful and Dusky Sounds revealed skin lesioning was more severe in Doubtful Sound, particularly among females, and newborn calves appeared to be smaller and were born over a shorter period: factors that may contribute to the low levels of calf survival in Doubtful Sound. The Fiordland bottlenose dolphins were assessed under IUCN Red List regional criteria. The small size of the population (205 individuals; 95% CI: 192-219) combined with the projected rate of decline in stochastic matrix models (average decline: 31.4% over one generation) resulted in a recommended classification of Critically Endangered.
Midlatitude atmospheric circulation responses under 1.5C and 2.0C warming and implications for regional impacts Midlatitude atmospheric circulation responses under 1.5C and 2.0C

This study investigates the global response of the midlatitude atmospheric circulation to 1.5 and 2.0 ◦ C of warming using the HAPPI (Half a degree Additional warming, Prognosis and Projected Impacts) ensemble, with a focus on the winter season. this for regional of multi-model mean response of midlatitudes; Case explore the implications of possible the tails of the response
11 βHSD 1 deficiency or inhibition enhances hepatic myofibroblast activation in murine liver fibrosis

Financial Support. This work was funded by the British Heart Foundation (BRW), a Henry Wellcome Postdoctoral Fellowship (ZM; 085458/Z/08/Z) and a British Heart Foundation/University of Edinburgh Centre of Research Excellence Transition Award Fellowship (ZM). Mice were generated under a Wellcome Trust Programme Grant 08318/4/Z/07/Z (to JR Seckl, JS Savill, KE Chapman, JJ Mullins and BRW). UE2316 was
Multiple scaling behaviour and nonlinear traits in music scores

We present a statistical analysis of music scores from different composers using detrended fluctuation analysis (DFA). We find different fluctuation profiles that correspond to distinct autocorrelation structures of the musical pieces. Further, we reveal evidence for the presence of nonlinear autocorrelations by estimating the DFA of the magnitude series, a result validated by a corresponding study of appropriate surrogate data. The amount and the character of nonlinear correlations vary from one composer to another. Finally, we performed a simple experiment in order to evaluate the pleasantness of the musical surrogate pieces in comparison with the original music and find that nonlinear correlations could play an important role in the aesthetic perception of a musical piece.
Pulmonary Pleomorphic Carcinoma: A Clinicopathological Study Including EGFR Mutation Analysis

Background: Pulmonary pleomorphic carcinoma is a rare epithelial tumor and has an aggressive clinical course. As few studies of pulmonary pleomorphic carcinoma have been described, the clinicopathological characteristics of the disease remain unclear. Especially, the information on the epidermal growth factor receptor (EGFR) mutation status of pulmonary pleomorphic carcinoma is sparse. Methods: We retrospectively examined 17 patients with pulmonary pleomorphic carcinoma. EGFR mutation and Ki-67 labeling index were investigated in these patients. Results: The median age of the patients was 72 years (range, 47–84 years). Thirteen patients were men and four were women. EGFR mutation was observed in 3 (18%) of 17 patients. The median value of Ki-67 labeling index was 62% (range, 20–87%). Positron emission tomography with 18-fluorodeoxy-glucose was performed in 16 patients, and the standardized uptake value tended to be high (median 19.3). The survival of patients without surgery demonstrated a significantly poor prognosis compared with those with surgery (P = 0.0096). Palliative chemotherapy was almost poor response in advanced pulmonary pleomorphic carcinoma. The response to gefitinib in a patient with EGFR mutation was small and transient. Conclusion: EGFR mutation was recognized in approximately 20% of patients with pulmonary pleomorphic carcinoma. It is necessary to investigate whether the use of a molecular targeting drug improves outcome for pulmonary pleomorphic carcinoma.
OcT4, sOX2, and nanOg positive expression correlates with poor differentiation, advanced disease stages, and worse overall survival in her2 + breast cancer patients

Objective: This study aimed to evaluate the correlations of expression of OCT4, SOX2, and NANOG with clinicopathological features and overall survival (OS) in human epidermal growth factor receptor 2-positive (HER2 + ) breast cancer (BC) patients. Methods: One hundred and thirty-four surgical HER2 + BC patients who received doxorubicin and cyclophosphamide followed by paclitaxel and trastuzumab adjuvant therapy were enrolled in this study. Immunofluorescence assay was used to detect OCT4, SOX2, and NANOG expressions. The median follow-up duration was 104 months, and the last follow-up date was December 31, 2017. Results: The expressions of OCT4 ( P = 0.001), SOX2 ( P = 0.003), and NANOG ( P = 0.005) were higher in tumor tissues compared with paired adjacent tissues. OCT4 positive expression was associated with poor pathological differentiation ( P = 0.028), larger tumor size ( P = 0.022), advanced N stage ( P , 0.001), and higher TNM stage ( P , 0.001). SOX2 positive expression was correlated with poor pathological differentiation ( P = 0.005), larger tumor size ( P = 0.013), and increased T stage ( P = 0.024). NANOG positive expression was associated with poor pathological differentiation ( P = 0.028), higher N stage ( P = 0.001), and elevated TNM stage ( P = 0.001). Kaplan–Meier curves disclosed that OCT4 ( P = 0.001) and NANOG ( P = 0.001) positive expressions were associated with worse OS, while SOX2 ( P = 0.058) positive expression was only numerically correlated with poor OS, but without statistical significance. Further analyses revealed that co-expression of these three biomarkers disclosed even better predictive value for shorter OS. Conclusion: OCT4, SOX2, and NANOG positive expressions correlate with poor differentiation and advanced disease stage, and OCT4 and NANOG present with predictive values for poor OS in HER2 + BC patients. present with more aggressive disease, greater likelihood of lymph node
Digital Citizenship: The Internet, Society, and Participation

Just as education has promoted democracy and economic growth, the Internet has the potential to benefit society as a whole. Digital citizenship, or the ability to participate in society online, promotes social inclusion. But statistics show that significant segments of the population are still excluded from digital citizenship. The authors of this book define digital citizens as those who are online daily. By focusing on frequent use, they reconceptualize debates about the digital divide to include both the means and the skills to participate online. They offer new evidence (drawn from recent national opinion surveys and Current Population Surveys) that technology use matters for wages and income, and for civic engagement and voting. Digital Citizenship examines three aspects of participation in society online: economic opportunity, democratic participation, and inclusion in prevailing forms of communication. The authors find that Internet use at work increases wages, with less-educated and minority workers receiving the greatest benefit, and that Internet use is significantly related to political participation, especially among the young. The authors examine in detail the gaps in technological access among minorities and the poor and predict that this digital inequality is not likely to disappear in the near future. Public policy, they argue, must address educational and technological disparities if we are to achieve full participation and citizenship in the twenty-first century.
Dyadic effects of perceived social support on family health and family functioning in patients with heart failure and their nearest relatives: Using the Actor#_#x2013;Partner Interdependence Mediation Model

• You may download this work for personal use only. • You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying this open access version If you believe that this document breaches copyright please contact us providing details and we will investigate your claim. Please direct all enquiries to puresupport@bib.sdu. dk
Physiological and Histological Effects of Fennel Seeds (Foeniculum Vulgare) on Kidneys in Male Rats

The present study aims to investigate the side effects of fennel seeds Foeniculum vulgare in male rats on the weights, histological changes and some of the physiological parameters of the kidney. The end of each experiment was followed by weighing the animals. Blood sample of each animal was collected by heart puncture then directly centrifuged, and the serum was kept at -80 oC for biochemical analysis and some histological standards, the animals were dissected, then the kidney was excised and fixed in neutral buffered 10% formalin for histological preparation. The increment in Urea, Total Protein and Creatinine. The result could be related to the high dose of fennel and duration of the study, which caused degeneration and necrosis of kidney cells and damage to peri tubules that led to prevention of secretion which raised Urea levels in the blood. Keyword: Foeniculum vulgare; urea; total protein; creatinine; necrosis The work is licensed under
2D-Dige as a strategy to identify serum protein biomarkers to monitor pharmacological efficacy in dopamine-dictated states of Parkinson’s disease and schizophrenia

Objectives: Parkinson’s disease and schizophrenia are clinical scenarios that occur due to dopaminergic deficit and hyperactivity in the midbrain, respectively. Current pharmacological interventions for these two diseases therefore aim to restore normal dopamine levels in the midbrain. But during therapy, there is a overshooting of dopamine concentrations that result in hallucinations in Parkinson’s disease patients and extra-pyramidal symptoms in schizophrenic patients. This causes a lot of inconvenience to the patents and the clinicians. There are no tests currently available to monitor drug efficacy in these two neuropsychiatric diseases. Materials and methods: Parkinson’s disease and schizophrenic naïve patients were recruited. Serum proteins isolated from these two clinical phenotypes were labeled with fluorescent cyanine dyes and analyzed by two-dimensional difference in gel electrophoresis proteomic experiment. Differentially expressed spots that had consistent expression pattern across five sets of biological replicate gels were trypsin digested and subjected to mass spectrometric analysis for protein identification. Validation experiments were done for the identified proteins using antibody-based assay on a patient cohort that included naïve, treated, and those who had side effects. Results: Serum α - and β -globin chains were identified as differentially expressed proteins having threefold higher expressions in Parkinson’s patients as compared to schizophrenia. Interestingly, concentrations of these two proteins had an inverse correlation across clinical phenotypes in the dopaminergic spectrum. RBC contamination as a source for these proteins was ruled out. Conclusion: There is a clear association of free serum globin with dopaminergic clinical states. This lays a platform for protein biomarker–based monitoring of pharmacological efficacy in Parkinson’s disease and schizophrenia.
Plasmodium vivax Readiness to Transmit : Implication for Malaria Eradication S 1 Text : Mathematical Models for P . falciparum and P . vivax

The model put forward for P. falciparum is based upon the Ross-MacDonald model [8, 9, 11] 5 developed specifically for malaria but has since been used for many vector-borne diseases. It is a 6 compartmental model of differential equations, i.e. both hosts (humans) and vectors (mosquitoes) 7 are split into different compartments determined by their infection status and we analyze how the 8 dynamics of each compartment changes over time. For P. falciparum humans are either Suscep9 tible, S(t), Exposed, E(t), Asymptomatic, A(t), Infected, I(t), or Removed, R(t). A proportion 10 of hosts will show symptoms and are labeled as Infected; the remaining proportion are Asymp11 tomatic but are still able to transmit the disease. Removed hosts are those which have temporary 12 immunity after a recent bout of infection. However, they lose this immunity and move back to 13 being Susceptible to P. falciparum after a number of days. Mosquitoes are classified as being 14 Susceptible, SM(t), Exposed, EM(t), or Infected, IM(T ). In both cases, Exposed implies that the 15 host or vector has been infected with the disease but is not able to transmit yet. That is, the 16 pathogen is currently proceeding through the internal stages within the host or mosquito. 17 All hosts are born Susceptible. These Susceptible hosts progress to the Exposed class (Figure 18 S1.1), due to a bite from an Infected vector (with some probability of successful transmission, see 19 Equations (1)-(8)). Once Exposed, a host becomes either Asymptomatic or Infected after a fixed 20 delay to account for the intrinsic incubation period, that is the number of days it takes for P. 21 falciparum to reach the blood stage. Whilst all hosts have a natural death rate which includes 22 death by natural causes and other factors unrelated to malaria infection, Infected hosts can also 23 die due to P. falciparum. Otherwise, Asymptomatic and Infected hosts clear the infection and 24 move to a Removed class, which indicates temporary immunity from P. falciparum. However, this 25 lasts only for a short time, at which point they move back to the Susceptible class. 26 Similarly, all vectors are born Susceptible. These Susceptible vectors progress to the Exposed 27 class after successful contact with an Infected host. They remain in the Exposed class for the 28 extrinsic incubation period, the duration of time for P. falciparum to move from the mid-gut of 29 the mosquito to the salivary glands. They progress to the Infected class and remain so for the 30
Perceptions of Mental Health among Pakistani Women with Micro-Finance Loans: An Interpretive Descriptive Study

Mental health has gained significant recognition and importance as a crucial aspect of overall well-being. An individual's mental health is influenced by the intersection of individual, social, cultural, and systematic sources of stress and resilience. It is important to include subjective conceptualizations of mental health and well-being to develop culturally sensitive approaches to mental health promotion. This qualitative study aimed to understand how urban-dwelling women living in Pakistan who are micro-finance loan recipients conceptualize the meaning of mental health. Using interpretive description methodology, data were collected and analyzed through in-depth, semi-structured interviews conducted in Urdu with a purposeful sample of 32 women. An inductive approach to content analysis was employed to code and categorize the data. Participants conceptualized mental health as the presence of peace and the absence of tension. Chronic sources of tension included a lack of essential resources, safety, and security in their day-to-day living in Karachi, Pakistan. Implementing policies to address women’s basic needs, including access to education, would be a helpful first step towards mental health promotion for Pakistani women. Integrating concepts that reflect women’s understanding of mental health will also be a useful first step in developing culturally sensitive mental health assessment tools.
Noninvasive mechanical ventilation on the ward for severe COPD: still unresolved question of balance among safety and drawbacks?

and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). International Journal of COPD 2016:11 2209–2210 International Journal of COPD Dovepress
Pediatric cataract surgery with hydrophilic acrylic intraocular lens implantation in nepalese children

Purpose: To assess the outcome of cataract surgery with hydrophilic acrylic intraocular lens (IOL) implantation in children with congenital and developmental cataracts. Method: A retrospective review of medical records of children with congenital or developmental cataracts who underwent cataract surgery with hydrophilic IOL implantation, from January 2011 to December 2014 in a tertiary eye hospital in Nepal. Primary posterior capsulotomy, anterior vitrectomy, and IOL implantation was done in children 8 years or younger, while older children underwent only lens aspiration and IOL implantation. Results: A total of 178 eyes of 120 children underwent cataract surgery with primary IOL implantation. Mean age at the time of surgery was 6.9 years (range: 3 months to 15 years). Average follow-up time was 13.7 ( ± 5.9) months. Associated ocular anomalies were present in 84 (47.1%) eyes. Postoperative complications were found in 33 eyes (18.13%) with inflammatory membrane being the most common (10.1%). Two eyes (1.1%) developed endophthalmitis. Second intervention was needed in 12 (6.5%) eyes. Preoperative vision of less than 6/60 was present in 105 eyes (57.69%). Final best corrected visual acuity of 6/12 or better was found in 81 (44.5%) eyes. Conclusion: Our study shows that hydrophilic IOL is suitable for use in children. Results of this study are comparable with other studies on pediatric cataract surgeries using hydrophobic acrylic intraocular lenses. Low cost hydrophilic lens implantation is an effective approach in managing pediatric cataract surgery in developing countries like Nepal. This study is a retrospective review of charts of all the children with congenital and developmental cataracts who underwent in Tilganga Institute of Ophthalmology between 2011 to 2014. Children with traumatic cataract, complicated cataracts, and secondary IOL implantations were excluded. The study was approved by the Institutional Review Board of Tilganga Institute of Ophthalmology and it adheres to the tenets of the Declaration of Helsinki. Informed consent was obtained from parents of the children included in the study. All the information was collected from the charts including demographics, lat-erality of cataract, presenting symptoms, associated ocular abnormalities, preoperative and final best corrected visual acuity, postoperative complications, second surgery, and the follow-up time. Visual acuity in children up to 3 years was determined by the central, steady and maintained fixation method. In children 3–6 years old, visual acuity was determined by E chart at m distance with matching optotype and in older children by the Snellen’s acuity chart. Anterior segment examination was done either by the slit or the operating microscope. Posterior segment examination was done by indirect ophthalmoscope or B scan ultrasound in dense media opacity. Optometry; Pharmacology drug therapy in eye Basic Sciences; Primary eye
The Historical Construction of Southeast Asian Studies: Korea and Beyond

At a time when Southeast Asian Studies is declining in North America and Europe, this book serves to remind us of the fresh, constructive and encouraging view of the field from Asia. On behalf of Taiwan's Southeast Asian research community, I sincerely congratulate Professors Park and King for making such a great and timely contribution to the making of Southeast Asian Studies in Asia.
Elementary Teachers’ Knowledge on Fraction Multiplication: An Anthropological Theory of the Didactic Approach

This study aims to evaluate Indonesian in-service elementary teachers’ knowledge on fraction by their responses to contextual problems on multiplication of a fraction by a whole number (O1) and multiplication of a fraction by a fraction (O2). Fifty Indonesian in-service elementary teachers from Elementary School for Teacher Education study program, University of Riau, participated in this research in 2015. This research is based on anthropological theory of the didactic (ATD), in particular praxeology, as a framework to analyse the data. The result showed that only 22% of Indonesian in-service elementary teachers have a satisfactory relation to O1 and 64% of them have succeeded on the problems related to O2.