Miracle-dz/UniFAR-FTUs huggingface dataset:
Activation of Antioxidant and Proteolytic Pathways in the Nigrostriatal Dopaminergic System After 3,4-Methylenedioxymethamphetamine Administration: Sex-Related Differences

3,4-Methylenedioxymethamphetamine (MDMA, “ecstasy”) is an amphetamine-related drug that may damage the dopaminergic nigrostriatal system. To investigate the mechanisms that sustain this toxic effect and ascertain their sex-dependence, we evaluated in the nigrostriatal system of MDMA-treated (4 × 20 mg/kg, 2 h apart) male and female mice the activity of superoxide dismutase (SOD), the gene expression of SOD type 1 and 2, together with SOD1/2 co-localization with tyrosine hydroxylase (TH)-positive neurons. In the same mice and brain areas, activity of glutathione peroxidase (GPx) and of β2/β5 subunits of the ubiquitin-proteasome system (UPS) were also evaluated. After MDMA, SOD1 increased in striatal TH-positive terminals, but not nigral neurons, of males and females, while SOD2 increased in striatal TH-positive terminals and nigral neurons of males only. Moreover, after MDMA, SOD1 gene expression increased in the midbrain of males and females, whereas SOD2 increased only in males. Finally, MDMA increased the SOD activity in the midbrain of females, without affecting GPx activity, decreased the β2/β5 activities in the striatum of males and the β2 activity in the midbrain of females. These results suggest that the mechanisms of MDMA-induced neurotoxic effects are sex-dependent and dopaminergic neurons of males could be more sensitive to SOD2- and UPS-mediated toxic effects.
Biomechanical Response of the Lower Extremity to Running-Induced Acute Fatigue: A Systematic Review

Objective: To investigate (i) typical protocols used in research on biomechanical response to running-induced fatigue, (ii) the effect of sport-induced acute fatigue on the biomechanics of running and functional tests, and (iii) the consistency of analyzed parameter trends across different protocols. Methods: Scopus, Web of Science, Pubmed, and IEEE databases were searched using terms identified with the Population, Interest and Context (PiCo) framework. Studies were screened following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and appraised using the methodological index for non-randomized studies MINORS scale. Only experimental studies with at least 10 participants, which evaluated fatigue during and immediately after the fatiguing run were included. Each study was summarized to record information about the protocol and parameter trends. Summary trends were computed for each parameter based on the results found in individual studies. Results: Of the 68 included studies, most were based on in-lab (77.9%) protocols, endpoint measurements (75%), stationary measurement systems (76.5%), and treadmill environment (54.4%) for running. From the 42 parameters identified in response to acute fatigue, flight time, contact time, knee flexion angle at initial contact, trunk flexion angle, peak tibial acceleration, CoP velocity during balance test showed an increasing behavior and cadence, vertical stiffness, knee extension force during MVC, maximum vertical ground reaction forces, and CMJ height showed a decreasing trend across different fatigue protocols. Conclusion: This review presents evidence that running-induced acute fatigue influences almost all the included biomechanical parameters, with crucial influence from the exercise intensity and the testing environment. Results indicate an important gap in literature caused by the lack of field studies with continuous measurement during outdoor running activities. To address this gap, we propose recommendations for the use of wearable inertial sensors.
Human Taeniasis and Cysticercosis and Related Factors in Phu Tho Province, Northern Vietnam

Several factors presumed to facilitate the transmission of Taenia spp. were reported in Vietnam. We conducted a cross-sectional study taking questionnaires from 1,185 participants, and collecting 1,151 sera and 1,036 stool samples in northern Vietnam. Sera were examined for circulating antigens of Taenia solium cysticerci using ELISA, stools for Taenia eggs by Kato-Katz smear, and copro-antigens by ELISA. Ag-ELISA revealed 4.6% antigen positivity, indicating infection with viable cysticerci. Taenia eggs were detected in 1.5% of participants. Copro-antigens were found in 2.8% of participants. Eating raw meat and/or vegetables was significantly associated with the presence of copro-antigen (OR=8.6, 95% CI: 1.16–63.9, P=0.01). Considering the high taeniasis prevalence and the associated threat, public health attention should be given to treat the tapeworm carriers in the projected areas.
Optimal Operating Conditions for Adsorption of Heavy Metals from an Aqueous Solution by an Agriculture Waste

The aim of this work is to detect the best operating conditions that effect on the removal of Cu, Zn, and Ni ions from aqueous solution using date pits in the batch adsorption experiments. The results have shown that the Al-zahdi Iraqi date pits demonstrated more efficient at certain values of operating conditions of adsorbent doses of 0.12 g/ml of aqueous solution, adsorption time 72 h, pH solution 5.5 ±0.2, shaking speed 300 rpm, and smallest adsorbent particle size needed for removal of metals. At the same time the particle size of date pits has a little effect on the adsorption at low initial concentration of heavy metals. The adsorption of metals increases with increasing the initial of metal concentration while above the 85 ppm, the removal efficiency was decreased. The phenomenon of adsorption of heavy metals on to Al-Zahdi Iraqi Date pits is exothermic process. The maximum adsorption capacity according to the Langmuir equation was 0.21, 0.149, and 0.132 mmol/g for Cu, Zn, and Ni respectively. The adsorption equilibrium was well described by the Freundlich model. The results of Freundlich constants indicated that the adsorption capacity and adsorption intensity of Copper is larger than the Zinc and Nickel. The intraparticle diffusion was involved is this process but it is not the controlling step. The results of this study may inspire to find the optimal operating conditions for adsorption and develop that with large-scale production to clean the polluted water with heavy metals.
A Time-Lag Study on Perceived Threat of COVID-19 in Hindu Religious Community: Moderating Role of Hindu Religious Coping

The COVID-19 pandemic had a serious impact on developing various psychological stressors in society. Grounded in cognitive appraisal theory, the current study has been conducted to investigate the moderating role of Hindu religious coping in mitigating the impact of the perceived threat of COVID-19 in developing perceived stress, insomnia, anxiety, and depression among the Hindu residents in Bali, Indonesia. The current study contributed to the body of knowledge regarding religious practices acting as a coping mechanism to help the community cope with crises scenario such as COVID-19. Using a longitudinal field survey, data were collected at two different times from 423 Hinduism believers who actively practiced religion and lived in Bali, Indonesia. Data were analyzed using measurement and structural models in SmartPLS. Results revealed that the perceived threat of COVID-19 impacted a higher level of stress, insomnia, anxiety, and depression among the target sample. Results further depicted that the intensity of the perceived threat of COVID-19 to develop negative stressors among those individuals is low who believe in Hinduism and practice religious obligations on a regular basis. This reflects the moderating role of Hindu religious coping in decreasing stress, insomnia, anxiety, and depression among Hindu believers aimed at COVID-19. © 2021.
Biodiversity of white grub, (Coleoptera: Scaraeidae) in semi arid agro-ecosystem of Rajasthan

White grubs are the major insect pests of cultivated plants in semi arid agro-ecosystem of Rajasthan. It is important to understand diversity, abundance and distribution of scarabaeid beetles for planning effective pest management programme. The experimental data were collected from9nine locations in 3three different ecosystems inKharif season of year 2019. Species identification revealed that there was total 9nine species were recorded from 18885 specimens collected. The identified species were belongs under 2two subfamilies of Scarabaeidae family. Maximum specimens were collected in the month of July from selected sites. When species diversitywas compared amongdifferent locations, itwas found that ShannonWiener diversity index varied from 1.235 to 1.095 which1.095, which indicates that species were less diverse but frequently present. The present study can be used to formulate the integrated pest management strategies based onmost abundance anddiverse scarabaeids in semi-arid agro-ecosystem of Rajasthan.
THEMATIC CONTENT FOR THE DEVELOPMENT OF A MOBILE APPLICATION ABOUT COVID-19

Objective: to analyze thematic content about covid-19 for the development of a mobile application for the population, from the perspective of health professionals. Method: qualitative research, developed in the state of Rio de Janeiro, between August and October 2020, through an electronic form with health professionals, whose data were processed in IRAMUTEQ software by the methods: Descending Hierarchical Classification, Correspondence Factor Analysis and Similarity Analysis. Results: the thematic contents identified for the development of the mobile application were protective and behavioral measures, accurate and reliable information on the facts surrounding covid-19, contagion, transmission, as well as information on care locations for the population. Conclusion: it is concluded that the availability of these contents in a mobile app is more than a facilitator for nurses; it presents itself as a critical component to transform nursing practice and education. DESCRIPTORS: Mobile Devices; Health Personnel; Coronavirus Infections; Pandemics; Health Education. dx.doi. org/10.5380/ce.v26i0. 78637 Cogitare enferm. 2021, v26:e78637 Michelly Cristynne Souza Bonifácio1 Aline Cerqueira Santos Santana da Silva1 Fernanda Garcia Bezerra Góes1 Andressa Silva Torres dos Santos1 Layanne Fonseca Pinto1 Yasminn Canella Cabral Banjar Coelho1 1Universidade Federal Fluminense. Rio das Ostras, RJ, Brasil. CONTENIDO TEMÁTICO PARA EL DESARROLLO DE UNA APLICACIÓN MÓVIL SOBRE COVID-19 RESUMEN: Objetivo: analizar los contenidos temáticos sobre el covid-19 para el desarrollo de una aplicación móvil para la población, desde la perspectiva de los profesionales de la salud. Método: investigación cualitativa, desarrollada en el estado de Río de Janeiro, entre agosto y octubre de 2020, a través de un formulario electrónico con profesionales de la salud, cuyos datos fueron procesados en el software IRAMUTEQ por los métodos: Clasificación Jerárquica Descendente, Análisis Factorial de Correspondencia y Análisis de Similitud. Resultados: los contenidos temáticos identificados para el desarrollo de la aplicación móvil fueron: medidas de protección y comportamiento, información precisa y fiable de los hechos que rodean al covid-19, el contagio, la transmisión, además de información sobre los lugares de atención a la población. Conclusión: se concluye que la disponibilidad de estos contenidos en una aplicación móvil es más que un facilitador para las enfermeras; se presenta como un componente crítico para transformar la práctica y la educación de la enfermería. DESCRIPTORES: Dispositivos Móviles; Personal de Salud; Infecciones por Coronavirus; Pandemias; Educación en Salud. Cogitare enferm. 2021, v26:e78637
Awareness and utilization of personal protective equipment among small-scale welders in Cross River State, Nigeria: a descriptive cross-sectional study

Objective: Rapid urbanization and industrialization in the many lowand middle-income countries means that there is a growing demand for the welding industry. Previous studies in Nigeria, and other lowand middle-income countries have reported a significant discrepancy between awareness and consistent and appropriate use of personal protective equipment (PPE). This study assessed the awareness and utilization of PPE among small scale welders in Calabar South, Cross River State, Nigeria. Methods: This study was conducted in Calabar South Local Government Area using a descriptive cross-sectional design. Data collection was with an interviewer-administered semi-structured questionnaire, and an observation checklist was used to monitor the use of PPE among small-scale welders. Results: One hundred and sixteen small-scale welders were surveyed with a mean age of 34.9 ±9.1 years. Almost 90% of respondents had completed at least primary education. Eighty-one respondents (69.8%) were aware of PPE. Three-quarters of respondents (61/81) knew PPE protected the user from injury. The most frequently identified type of welding PPE among the respondents aware of PPE, were safety goggles (38.3%), hand gloves (25.9%), safety boots (19.8%), and coveralls (9.9%). 83.6% had access to PPE at work. However, only 14.4% reported using PPE consistently. Observation revealed that the PPE most frequently used, sunglasses, were not the recommended welding goggles. Conclusion: The low utilization of PPE calls for stricter enforcement of occupational health and safety regulations among welders in the informal sector, including implementing PPE awareness programs.
Response of Broiler Chicks to Low-Energy Diet Supplemented With Lecithin or Xylanase Enzyme

Two experiments were conducted to study the effect of adding soy-lecithin or xylanase to low-energy diet on broilers growth performance, nutrient digestibility, intestinal lipase enzyme activity and economical efficiency. A total number of 256 unsexed Cobb500 broiler chicks, a day old, were classified into two equal experiments, 128 chicks each (4 treatments × 4 replicates × 8chicks). In each experiment, chicks were divided into 4 groups as follows: the 1 group fed basal diet and served as control which fed recommended energy diet, the 2 group fed diet low (100 Kcal / kg diet) than recommendation (LED), the 3 and 4 groups were fed 2 diet added with 0.5g lecithin / kg diet or 1.0g lecithin / kg diet, respectively (EXP.1). While, chicks were fed 2 diet supplemented with 0.1g xylanase / kg diet or 0.2g xylanase / kg diet, respectively (EXP.2). The growth trail was lasted at 35 days of age. The results revealed that, groups of LED + 0.5g lecithin (EXP.1) and LED + 0.2g xylanase (EXP.2) recorded significantly higher BWG and better FCR during overall period than control and LED groups. In both experiments, there is a gradual increase in EE% digestibility coefficient, intestinal lipase activity and economical efficiency by increasing the addition level of either soy-lecithin or xylanase. It could be concluded that enriching low-energy diet with either 0.5g lecithin / kg diet or 0.2g xylanase / kg diet can improve broilers growth performance, intestinal lipase activity and enhanced economical net profit.
ANALYSIS OF THE RECURRENCE OF STROKE: A CROSS-SECTIONAL STUDY IN THE UNIVERSITY OF MUHAMMADIYAH MALANG HOSPITAL

Background: a recurrence of stroke, is a matter of concern because it can worsen the situation, increase the treatment costs, and increase death risk. Stroke recurrence caused by multifactorial cases. The objective of this study is to analyze the factors associated with stroke recurrence in the university of muhammadiyah malang hospital. Methods: This study used a cross-sectional observation analytic study. A total sample of 64 people was collected using the purposive sampling technique. The dependent variable in this study was stroke recurrence. The independent variables were the factors that cause stroke recurrence (family history of the disease, comorbidities, physical activity, stress, and knowledge). This study used the Global Physical Activity Questionnaire(GPAQ), the International Stress Management Association(ISMA), and socio-demographic questionnaire to collect the data. The data were analyzed using the Chi-Square test. Results: a total of 47 patients (73.43%) had stroke recurrence, the majority of the second recurrence. Most types of stroke were ischemic stroke (81.25%). The risk factor significantly associated with stroke recurrence was hypertension (sig 0.026 <0.05). Conclusion: Uncontrolled hypertension increases the process of atherosclerosis that can lead to bleeding and brain infarction.
Prevalence and risk factors for menopausal symptoms in middle-aged Chinese women: a community-based cross-sectional study

Supplemental Digital Content is available in the text Abstract Objectives: To examine the prevalence and risk factors of menopausal symptoms in middle-aged Chinese women. Methods: A cross-sectional, community-based study recruited 6,745 women aged 40 to 55 years in the eastern, central, and western regions of China during 2018. Menopausal status was categorized into reproductive stage (defined as regular menstruation or subtle changes in menstrual cycle characteristics), menopausal transition (the beginning of a persistent difference of 7 d in the length of consecutive cycles, or the last menstruation having occurred no more than 12 mo), or postmenpause (the end of the 12 mo period of amenorrhea) according to the Stages of Reproductive Aging Workshop classification. Menopausal symptoms were determined by the modified Kupperman Menopausal Index (KMI) questionnaire and considered nonmenopausal symptoms (total KMI score<15) and menopausal symptoms (total KMI score≥15). Demographic, lifestyle, physical, and menopausal characteristics were collected by face-to-face interviews. Logistic regression models were used to identify factors associated with the risk of menopausal symptoms. Results: Among all participants, the mean age was 46.9 years, and 15.7% (1,001/6,364) of participants reported experiencing menopausal symptoms. The prevalence of menopausal symptoms was 9.3% (303/3,256), 23.9% (293/1,227), and 21.5% (405/1,881) in the reproductive stage, menopausal transition, and postmenopausal stage, respectively. Overall, the three most prevalent menopausal symptoms were insomnia (44.7%), fatigue (40.4%), and mood swings (37.2%). The multivariable logistic regression model showed that menopausal status, residence, nulliparity, and chronic diseases were associated with the risk of menopausal symptoms (all P < 0.05). Women during menopausal transition (OR = 2.66, 95% CI: 2.21-3.20) or postmenopause (OR = 2.26, 95% CI: 1.82-2.80) had significantly increased risk of menopausal symptoms compared with those in the reproductive stage. Conclusions: Menopausal status, residence, nulliparity, and chronic diseases were associated with menopausal symptoms in middle-aged Chinese women.
Reminiscence-Focused Music Therapy to Promote Positive Mood and Engagement and Shared Interaction for People Living With Dementia

Although there is a growing body of evidence suggesting that combining music therapy and reminiscence in a structured and complementary way may yield positive well-being outcomes for people with dementia, there is a gap in the literature combining both in equal measure. Furthermore, there are no known studies exploring the use of ‘associative items’ as part of the combined intervention and no known standardised protocol or method currently exists. This mixed methods study aims to explore whether combining music therapy and reminiscence with associative items for people with dementia may promote positive mood and engagement levels and shared interaction through (a) musical expression, (b) reminiscence and (c) verbal interaction. Five weekly reminiscence-focused music therapy (RFMT) sessions with associative items were conducted with a group of five people with dementia living in a residential care unit. Results from the Dementia Care Mapping (DCM) revealed that the RFMT intervention was highly effective in promoting positive mood and engagement levels and shared interaction. Participants exhibited considerable positive mood and engagement (+3) 51.6%, and high positive mood and engagement (+5) 38.2%, of the total time observed. The three most frequent behaviours across the five RFMT sessions included musical expression, which was observed 53.2% of the time, reminiscence, observed 23% of the time, and verbal interaction, observed 34% of the total time observed. Data from the music therapist’s reflective journal and session summaries revealed that the associative items prompted reality orientation, verbal interaction, and cognitive stimulation. The music elements were found to increase group cohesion, stimulate cognition, and act as an anchor, re-orientatVOICES: A WORLD FORUM FOR MUSIC THERAPY | VOL 21 | NO 2 | 2021 Publisher: GAMUT Grieg Academy Music Therapy Research Centre (NORCE & University of Bergen) Copyright: 2021 The Author(s). This is an open-access article distributed under the terms of the http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. DOI: https://doi.org/10.15845/voices.v21i2. 3139 ing group members intermittently. Implications of practice are considered, and future recommendations of practice are outlined.
Gut Microbiota: Novel Therapeutic Target of Ginsenosides for the Treatment of Obesity and Its Complications

Obesity, generally characterized by excessive lipid accumulation, is a metabolic threat worldwide due to its rapid growth in global prevalence. Ginsenosides are crucial components derived from natural plants that can confer metabolic benefits for obese patients. Considering the low bioavailability and degradable properties of ginsenosides in vivo, it should be admitted that the mechanism of ginsenosides on anti-obesity contribution is still obscure. Recently, studies have indicated that ginsenoside intervention has beneficial metabolic effects on obesity and its complications because it allows for the correction of gut microbiota dysbiosis and regulates the secretion of related endogenous metabolites. In this review, we summarize the role of gut microbiota in the pathogenetic process of obesity, and explore the mechanism of ginsenosides for ameliorating obesity, which can modulate the composition of gut microbiota by improving the metabolism of intestinal endogenous substances and alleviating the level of inflammation. Ginsenosides are expected to become a promising anti-obesity medical intervention in the foreseeable clinical settings.