Miracle-dz/UniFAR-FTUs huggingface dataset:
Energy productivity and environmental quality in Sweden: Evidence from Fourier and non‐linear based approaches

This study aims to examine the asymmetric and long‐run effects of energy productivity on the quality of the environment in Sweden. It covers the time series data from 1990Q1 to 2019Q4. Sweden was the first country in 1972 to host a United Nations conference on the environment. Unlike other countries in Europe, Sweden is cognizant of an innovative environment; it hopes to achieve 100% of its electricity from renewable sources by 2040 and lead the way towards a low‐carbon community. The novelty of this study lies in the thorough analysis of how energy productivity affects the quality of the environment in Sweden while controlling for economic growth, trade openness, and financial development utilizing the non‐linear ARDL approach and other robust econometric techniques. Precisely, (i) results indicate non‐linear and asymmetric effects of the variables over long‐term horizons; (ii) energy productivity benefits the environment by lowering CO2 emissions (CO2E) in the long term; (iii) a growth in trade openness positively impacts CO2E; (iv) an increase in financial development and economic growth without eco‐friendly protocols contribute to an increase in CO2E. The findings of this study support the economic theory that energy productivity can stimulate green living and green economic growth. We recommend that policymakers in Sweden invest in energy productivity, pursue R&D that embraces cleaner technologies, and prioritize cleaner, cross‐cutting eco‐friendly policies to combat climate challenges and achieve the long‐term climate policy goals of the EU.
Gender-Specific Associations between Late-Life Disability and Socioeconomic Status: Findings from the International Mobility and Aging Study (IMIAS)

Disability is a dynamic process and can be influenced by a sociocultural environment. This study aimed to determine whether the associations between socioeconomic status and late-life disability differ by gender in a multi-sociocultural sample from different countries. A cross-sectional study was developed with 1362 older adults from The International Mobility in Aging Study. Late-life disability was measured through the disability component of the Late-Life Function Disability Instrument. Level of education, income sufficiency and lifelong occupation were used as indicators of SES. The results indicated that a low education level β = −3.11 [95% CI −4.70; −1.53] and manual occupation β = −1.79 [95% −3.40; −0.18] were associated with frequency decrease for men, while insufficient income β = −3.55 [95% CI −5.57; −1.52] and manual occupation β = −2.25 [95% CI −3.89; −0.61] played a negative role in frequency for women. For both men β = −2.39 [95% −4.68; −0.10] and women β = −3.39 [95% −5.77; −1.02], insufficient income was the only factor associated with greater perceived limitation during life tasks. This study suggested that men and women had different late-life disability experiences. For men, occupation and education were associated with a decrease in the frequency of participation, while for women this was associated with income and occupation. Income was associated with perceived limitation during daily life tasks for both genders.
A Single Aptamer-Dependent Sandwich-Type Biosensor for the Colorimetric Detection of Cancer Cells via Direct Coordinately Binding of Bare Bimetallic Metal–Organic Framework-Based Nanozymes

A typical colorimetric sandwich-type sensor relies on dual antibodies/aptamers to specifically visualize the targets. The requirement of dual antibodies/aptamers and low signal intensity inevitably increases the design difficulty and compromises the sensing sensitivity. In this work, a novel sandwich-type aptasensor was developed using single aptamer-functionalized magnetic nanoparticles as a specific recognition unit to target cancer cells and a bimetallic metal–organic frameworks (MOFs)-based nanozymes as a colorimetric signal amplification unit. The well-defined crystalline structure of UIO-66 MOFs enabled the introduction of Fe/Zr bimetal nodes, which possessed integrated properties of the peroxidase-like nanozyme activity and direct coordinately binding to the cell surface. Such a novel construction strategy of sandwich-type aptasensors achieved simple, sensitive, and specific detection of the target cancer cells, which will inspire the development of biosensors.
Uranium-doped thallium-1223 superconductors

The effect of incorporating uranium into thallium-based superconducting samples has been investigated. Oxidic precursor material of the formal stoichiometry (Tl0.6Pb0.5)(Sr0.8Ba0.2)2Ca2Cu3UxOy was prepared by a wet chemical route followed by solid-state reactions. x values of 0.005, 0.01 and 0.02 yielded almost the pure Tl-1223 phase with Tc(0) values of 114 K. For x values of 0.08 and 0.2, considerable amounts of the Tl-1212 phase were found, two-step transitions were observed in the resistance-temperature curves and the Tc(0) values dropped to 107 K and 103 K, respectively. Energy dispersive x-ray analysis indicated that uranium was incorporated into the superconducting crystallites. Concentrations of uranium above x = 0.2 did not result in superconducting material. The introduction of uranium into the tetragonal Tl-1223 phase led to a decrease in the c-axis, but did not affect the a-axis.
DEPENDENCE OF THE TURBULENT VELOCITY FIELD ON GAS DENSITY IN L1551

We have carried out mapping observations of the entire L1551 molecular cloud with about 2 pc × 2 pc size in the 12CO(1–0) line with the Nobeyama 45 m radio telescope at the high effective resolution of 22″ (corresponding to 0.017 pc at the distance of 160 pc), and analyzed the 12CO data together with the 13CO(1–0) and C18O(1–0) data from the Nobeyama Radio Observatory database. We derived the new non-thermal line width–size relations, σNT ∝ L γ, for the three molecular lines, corrected for the effect of optical depth and the line-of-sight integration. To investigate the characteristic of the intrinsic turbulence, the effects of the outflows were removed. The derived relations are (σNT/km s−1) = (0.18 ± 0.010)(L/pc)0.45 ± 0.095, (0.20 ± 0.020)(L/pc)0.48 ± 0.091, and (0.22 ± 0.050) (L/pc)0.54 ± 0.21 for the 12CO, 13CO, and C18O lines, respectively, suggesting that the line width–size relation of the turbulence very weakly depends on our observed molecular lines, i.e., the relation does not change between the density ranges of 102–103 and 103–104 cm−3. In addition, the relations indicate that incompressible turbulence is dominant at the scales smaller than 0.6 pc in L1551. The power spectrum indices converted from the relations, however, seem to be larger than that of the Kolmogorov spectrum for incompressible flow. The disagreement could be explained by the anisotropy in the turbulent velocity field in L1551, as expected in MHD turbulence. Actually, the autocorrelation functions of the centroid velocity fluctuations show larger correlation along the direction of the magnetic field measured for the whole Taurus cloud, which is consistent with the results of numerical simulations for incompressible MHD flow.
C-Reactive Protein Levels Are Associated with Complement C4 Deposits and Interstitial Arteritis in ANCA-Associated Renal Vasculitis

Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a potentially life-threatening systemic small-vessel vasculitis that is characterized by pauci-immune glomerulonephritis in case of kidney involvement, representing a major denominator of AAV mortality. Innate immunity with complement system activation is increasingly recognized in the pathogenesis of AAV and as an attractive therapeutic target. Although C-reactive protein (CRP) was thought to be a passive, nonspecific marker of inflammation, recent studies indicate that CRP plays a key role in the innate immune system by recognizing pathogens and altered self-determinants. Elevated baseline CRP at disease onset of AAV has already been described as a determinant of poor long-term outcomes. However, its clinical implications at disease onset of AAV, with respect to vasculitis manifestations and complement system activation that might also affect long-term outcomes, remain elusive. CRP levels were retrospectively analyzed in 53 kidney-biopsy-confirmed cases of ANCA-associated renal vasculitis; a total of 138 disease controls were also evaluated. Univariate and multivariate regression analysis was performed on clinicopathological parameters associated with CRP levels in ANCA-associated renal vasculitis. Results: Compared to disease controls, CRP elevation was common in ANCA-associated renal vasculitis and associated with de novo disease (p = 0.0169), critical illness (p = 0.0346), and severe deterioration of kidney function (p = 0.0167), independent of extrarenal disease manifestations. As confirmed by multiple regression analysis, CRP levels were correlated with active lesions predominated by interstitial arteritis in renal vasculitis, specifically with MPO-ANCA seropositivity (p = 0.0017). Based on analysis of systemic complement system activation and intrarenal complement deposits, CRP elevation was correlated specifically with complement C4 deposits in interstitial arteries in the subgroup with myeloperoxidase (MPO)-ANCA seropositivity (p = 0.039). Finally, this association was independent of systemic complement system activation, as reflected by the consumption of respective complement components. Here, we expand our current understanding of CRP in ANCA-associated renal vasculitis not only as an inflammatory marker, but potentially also as being involved in the pathogenesis of kidney injury by interaction with the complement system.
Potential Biological Markers and Treatment Implications for Binge Eating Disorder and Behavioral Addictions

The reward system is highly relevant to behavioral addictions such as gambling disorder (GD), internet gaming disorder (IGD), and food addiction/binge eating disorder (FA/BED). Among other brain regions, the ventral striatum (VS) has been implicated in reward processing. The main objective of the present state-of-the-art review was to explore in depth the specific role of the VS in GD, IGD and FA/BED, understanding it as a possible biomarker of these conditions. Studies analyzing brain changes following interventions for these disorders, and especially those that had explored possible treatment-related changes in VS, are discussed. More evidence is needed on how existing treatments (both pharmacological and psychobehavioral) for behavioral addictions affect the activation of the VS and related circuitry.
Azimuthal structure of turbulence in high Reynolds number pipe flow

Two-point hot-wire measurements of streamwise velocity were performed in the logarithmic and wake regions of turbulent pipe flow for Reynolds numbers, based on pipe diameter, ranging from 7.6 × 104 to 8.3 × 106 at four wall-normal positions with azimuthal probe separation. The azimuthal correlations were found to be consistent with the presence of very large-scale coherent regions of low-wavenumber, low-momentum fluid observed in previous studies of wall-bounded flows and were found to be independent of changing Reynolds number and surface roughness effects. At the edge of the logarithmic layer the azimuthal scale determined from the correlations was found to be similar to that observed for channel flows but larger than that observed for boundary layers, inconsistent with the concept of a universal logarithmic region. As the wall-normal position increased outside the logarithmic layer, there was a decrease in azimuthal scale relative to that of channel flow. Using cross-spectral analysis, high-wavenumber motion was found to grow azimuthally with wall-normal distance at a faster rate than the low-wavenumber motions.
The Profiles and Functions of RNA Editing Sites Associated with High-Altitude Adaptation in Goats

High-altitude environments dramatically influenced the genetic evolution of vertebrates. However, little is known about the role of RNA editing on high-altitude adaptation in non-model species. Here, we profiled the RNA editing sites (RESs) of heart, lung, kidney, and longissimus dorsi muscle from Tibetan cashmere goats (TBG, 4500 m) and Inner Mongolia cashmere goats (IMG, 1200 m) to reveal RNA editing-related functions of high-altitude adaptation in goats. We identified 84,132 high-quality RESs that were unevenly distributed across the autosomes in TBG and IMG, and more than half of the 10,842 non-redundant editing sites were clustered. The majority (62.61%) were adenosine-to-inosine (A-to-I) sites, followed by cytidine-to-uridine (C-to-U) sites (19.26%), and 32.5% of them had a significant correlation with the expression of catalytic genes. Moreover, A-to-I and C-to-U RNA editing sites had different flanking sequences, amino acid mutations, and alternative splicing activity. TBG had higher editing levels of A-to-I and C-to-U than IMG in the kidney, whereas a lower level was found in the longissimus dorsi muscle. Furthermore, we identified 29 IMG and 41 TBG population-specific editing sites (pSESs) and 53 population-differential editing sites (pDESs) that were functionally involved in altering RNA splicing or recoding protein products. It is worth noting that 73.3% population-differential, 73.2% TBG-specific, and 80% IMG-specific A-to-I sites were nonsynonymous sites. Moreover, the pSESs and pDESs editing-related genes play critical functions in energy metabolisms such as ATP binding molecular function, translation, and adaptive immune response, which may be linked to goat high-altitude adaptation. Our results provide valuable information for understanding the adaptive evolution of goats and studying plateau-related diseases.
Tocotrienol in the Management of Nonalcoholic Fatty Liver Disease: A Systematic Review

The increasing burden of nonalcoholic fatty liver disease (NAFLD) requires innovative management strategies, but an effective pharmacological agent has yet to be found. Apart from weight loss and lifestyle adjustments, one isomer of the vitamin E family—alpha-tocopherol—is currently recommended for nondiabetic steatohepatitis patients. Another member of the vitamin E family, tocotrienol (T3), has anti-inflammatory and antioxidant properties that reach beyond those of alpha-tocopherol, making it a potential agent for use in NAFLD management. This systematic review aimed to provide an overview of the effects of T3 supplementation on NAFLD from both clinical and preclinical perspectives. A literature search was performed in October 2022 using PubMed, Scopus and Web of Science. Original research articles reporting NAFLD outcomes were included in this review. The search located 12 articles (8 animal studies and 4 human studies). The literature reports state that T3 isomers or natural mixtures (derived from palm or annatto) improved NAFLD outcomes (liver histology, ultrasound or liver profile). However, the improvement depended on the severity of NAFLD, study period and type of intervention (isomers/mixture of different compositions). Mechanistically, T3 improved lipid metabolism and prevented liver steatosis, and reduced mitochondrial and endoplasmic reticulum stress, inflammation and ultimately liver fibrosis. In summary, T3 could be a potential agent for use in managing NAFLD, pending more comprehensive preclinical and human studies.
Text-Based Emotion Detection using CNN-BiLSTM

Social media is not only used by the public to convey information but also to express emotions in writing. Text-based emotion detection is needed to find out the emotions contained in the text. This study combines CNN and BiLSTM for text-based emotion detection and compares the use of word embedding such as Word2Vec and GloVe. The data types used in this study are commuter line, transjakarta and commuter line + transjakarta. This study uses two scenarios, namely scenario I which classifies the dataset into emotion and no-emotion classes and scenario II which classifies emotions into five types of emotions, namely happiness, anger, sadness, fear, surprise. This study has two experimental types to emotion detection based on text, namely Word2Vec-CNN-BiLSTM, and GloVe-CNN-BiLSTM. In scenario I, Word2Vec-CNN-BiLSTM outperforms GloVe-CNN-BiLSTM in terms of accuracy. The accuracy values generated by Word2Vec-CNN-BiLSTM on the commuter line, transjakarta and commuter line + transjakarta data are 84.34%,83. %73%, and 83.88%, respectively. Word2Vec-CNN-BiLSTM provides the best overall Precision, Recall and F1-Measure compared with GloVe-CNN-BiLSTM on all data. The same result is also shown in scenario II where accuracy, precision, recall and F1-measure in Word2Vec-CNN-BiLSTM are better than other methods. The results of this study also improve the performance of emotion detection in text compared to the results of previous studies using Word2Vec-BiLSTM.
Does Post-COVID-19 Erectile Dysfunction Improve over Time?

Background: Some studies have shown that there may be an increase in the frequency of erectile dysfunction after COVID-19. However, no long-term study has investigated whether this is permanent or temporary. In this study, we aimed to examine whether there was an increase in the frequency of erectile dysfunction among individuals with a history of COVID-19, and, if there was, whether their condition improved over time. Materials and methods: In this study, a total of 125 healthy male healthcare workers, 95 with and 30 without a history of COVID-19, were evaluated in terms of erectile function. Four study groups were formed. The first three groups consisted of individuals with a history of COVID-19 confirmed by the polymerase chain reaction (PCR) test at different times, who recovered from the disease (time elapsed since COVID-19 positivity: <6 months for Group 1, 6 to 12 months for Group 2, and >12 months for Group 3). The individuals in Group 4 did not have a history of COVID-19 diagnosis. In order to evaluate the erectile function of the participants, they were asked to complete the five-item International Index of Erectile Function questionnaire (IIEF-5). Then, statistical analyses were performed to evaluate whether there was a difference between the groups in terms of the IIEF-5 scores. Results: There was a statistically significant difference between the groups in terms of the IIEF-5 scores (p < 0.001), and this difference was determined to be caused by the significantly higher IIEF-5 scores of Groups 3 and 4 compared to Group 1 (p = 0.004 and p < 0.001, respectively). In addition, the IIEF-5 score of Group 4 was statistically significantly higher than that of Group 2 (p < 0.001). However, the IIEF-5 scores did not statistically significantly differ between Groups 1 and 2, Groups 2 and 3, and Groups 3 and 4 (p > 0.999, p = 0.204, and p = 0.592, respectively). Conclusion: There may be deterioration in erectile function after COVID-19; however, this tends to improve over time, especially from the first year after active infection. Given that vascular, hormonal, and/or psychogenic factors may lead to the development of erectile dysfunction after COVID-19, we consider that in order to easily manage this process, it is important to determine the underlying cause, initiate appropriate treatment, and inform couples that this situation can be temporary.
The Robot-Gender Divide: How and Why Men and Women Differ in Their Attitudes Toward Social Robots

Recent developments foretell that social robots will soon become an integral part of everyday life, offering companionship and intimate closeness of different kinds. While research thus far is limited in scope and data, the current research offers two studies into how and why gender affects social robots’ acceptance among European and American participants. Study 1 (N = 26,344) is used to identify overall patterns, while Study 2 (N = 426), divided into quantitative and qualitative analyses, is used to investigate specific differences in accepting four types of robots: helpers, companions, lovers, and sex partners. Results show that women have significantly less positive attitudes toward social robots as lovers and sex partners than men. The qualitative analyses of Study 2 show that this is due to women seeing such robots more negatively in terms of social norms, psychological health, morality, and functionality. The study further offers an axis system, on which attitudes toward robots can be theorized and examined.
Healthcare Systems across Europe and the US: The Managed Entry Agreements Experience

This systematic study aims at analyzing the differences between the approach of the European healthcare systems to the pharmaceutical market and the American one. This paper highlights the opportunities and the limitations given by the application of managed entry agreements (MEAs) in European countries as opposed to the American market, which does not regulate pharmaceutical prices. Data were collected from the Organisation for Economic Co-operation and Development (OECD), the European Medicines Agency, and the national healthcare agencies of US and European countries. A literature review was undertaken in PubMed, Scopus, MEDLINE, and Google for a period ten years (2010–2019). The period 2020–2021 was considered to compare health expenditure before and after the SARS-CoV-2 pandemic. Scarce information from national agencies has been given in terms of MEAs related to the COVID-19 pandemic. The comparison between the United States approach and the European one shows the importance of a market access regulation to reduce the cost of therapies, increasing the efficiency of national healthcare systems and the advantages in terms of quality and accessibility to the final users: patients. Nevertheless, it seems that the golden age of MEAs for Europe was during the examined period. Except for Italy, countries will move to other forms of reimbursements to obtain higher benefits, reducing the costs of an inefficient implementation and outcomes in the medium term.
Effect of Hydroxyapatite/β-Tricalcium Phosphate on Osseointegration after Implantation into Mouse Maxilla

In our previous study we established an animal model for immediately placed implants using mice and clarified that there were no significant differences in the chronological healing process at the bone-implant interface between immediately and delayed placed implants blasted with hydroxyapatite (HA)/β-tricalcium phosphate (β-TCP) (ratio 1:4). This study aimed to analyze the effects of HA/β-TCP on osseointegration at the bone-implant interface after immediately placed implants in the maxillae of 4-week-old mice. Right maxillary first molars were extracted and cavities were prepared with a drill and titanium implants, blasted with or without HA/β-TCP, were placed. The fixation was followed-up at 1, 5, 7, 14, and 28 days after implantation, and the decalcified samples were embedded in paraffin and prepared sections were processed for immunohistochemistry using anti-osteopontin (OPN) and Ki67 antibodies, and tartrate-resistant acid phosphatase histochemistry. The undecalcified sample elements were quantitatively analyzed by an electron probe microanalyzer. Bone formation occurred on the preexisting bone surface (indirect osteogenesis) and on the implant surface (direct osteogenesis), indicating that osseointegration was achieved until 4 weeks post-operation in both of the groups. In the non-blasted group, the OPN immunoreactivity at the bone-implant interface was significantly decreased compared with the blasted group at week 2 and 4, as well as the rate of direct osteogenesis at week 4. These results suggest that the lack of HA/β-TCP on the implant surface affects the OPN immunoreactivity on the bone-implant interface, resulting in decreased direct osteogenesis following immediately placed titanium implants.