Miracle-dz/UniFAR-FTUs huggingface dataset:
Transcriptomic and Targeted Metabolomics Analysis of Detached Lycium ruthenicum Leaves Reveals Mechanisms of Anthocyanin Biosynthesis Induction through Light Quality and Sucrose Treatments

Light quality and sucrose-induced osmotic stress are known to cause anthocyanin synthesis in detached Lycium ruthenicum leaves. To identify the mechanisms by which the kind of light quality and sucrose concentration are induced, here, we conducted transcriptome sequencing in detached L. ruthenicum leaves treated with different qualities of light and sucrose concentrations. Leaves treated with blue light or sucrose showed a significantly increased total anthocyanins content compared to those treated with white light. Delphinidin-3-O-rutinoside and delphinidin-3-O-glucoside production were differentially regulated by the BL(−S), BL(+S), and WL(+S) treatments. The structural genes CHS, CHI, F3′H, F3′5′H, ANS, and UFGT were significantly up-regulated in leaves treated with blue light or sucrose. Leaves treated with blue light additionally showed up-regulation of the light photoreceptors CRY1, PIF3, COP1, and HY5. The anthocyanin-related genes NCED1, PYR/PYL, PP2C, SnRK2, and ABI5 were significantly up-regulated in leaves treated with sucrose, promoting adaptability to sucrose osmotic stress. Co-expression and cis-regulatory analyses suggested that HY5 and ABI5 could regulate LrMYB44 and LrMYB48 through binding to the G-box element and ABRE element, respectively, inducing anthocyanin synthesis in response to blue light or sucrose treatment. Candidate genes responsive to blue light or sucrose osmotic stress in the anthocyanin biosynthesis pathway were validated through quantitative reverse transcription PCR. These findings deepen our understanding of the mechanisms by which blue light and sucrose-induced osmotic stress regulate anthocyanin synthesis, providing valuable target genes for the future improvement in anthocyanin production in L. ruthenicum.
I Didn’t Win! An Overlooked Downside of Crowdsourcing?

This research identifies a surprising downside to using crowdsourcing to generate new product ideas: participants who do not win an idea generation contest temporarily disengage from the contest-hosting brand. When people lose a crowdsourcing contest, the experience of losing negatively affects the participants’ word-of-mouth and short-term purchase behaviors. Reframing the contest as a community activity (e.g., “Join the crowd and help us find a name for our new restaurant”) rather than a competition (e.g., “Compete with the crowd to be the one who names our new restaurant”) is found to positively affect a losing customer's subsequent engagement with the contest-hosting brand. Community framing shifts attention away from losing the contest (i.e., it reduces negative affect) and toward collectively creating a superior outcome (i.e., it increases one's perceived contribution), without changing the nature of the contest itself (i.e., participants continue to submit ideas). Community framing positively affects subsequent participant engagement, but it does not influence the effort the participant invests in the contest or the quality of the idea the participant submits. The evidence consists of lab experiments, field experiments, and a large-scale field study that measured actual purchase behavior.
Value co-creation through social innovation: A study of sustainable strategic alliance in telecommunication and financial services sectors in Bangladesh

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ANALISIS FRAUD DIAMOND DALAM MENDETEKSI FINANCIAL STATEMENT FRAUD (STUDI EMPIRIS PADA PERUSAHAAN MANUFAKTUR SEKTOR INDUSTRI BARANG KONSUMSI YANG TERDAFTAR DI BURSA EFEK INDONESIA (BEI) TAHUN 2017-2019)

Penelitian ini bertujuan untuk menganalisis pengaruh financial stability, external pressure, nature of industry, change in auditor dan pergantian direksi dalam mendeteksi financial statement fraud. Penelitian ini menggunakan jenis penelitian deskriptif kuantitatif. Sumber data dalam penelitian ini adalah data sekunder berupa data laporan keuangan tahunan perusahaan manufaktur sektor industri barang konsumsi yang terdaftar di Bursa Efek Indonesia (BEI) selama periode 2017-2019. Pemilihan sampel pada penelitian ini dengan menggunakan purposive sampling. Berdasarkan kriteria yang telah ditentukan diperoleh sampel sebanyak 25 perusahaan sehingga data observasi berjumlah 75. Uji hipotesis yang digunakan adalah analisis regresi model panel menggunakan program Eviews 9.0. Hasil penelitian ini menunjukan bahwa financial stability berpengaruh positif signifikan terhadap financial statement fraud. Sedangkan external pressure, nature of industry, change in auditor dan pergantian direksi tidak berpengaruh terhadap financial statement fraud.
Variation in individual life-history trajectories and its consequence on population dynamics : the case of roe deer

Roe deer give birth each year in May. At each reproductive event, a female can be in different reproductive statuses: breeder or non breeder and can wean a variable number of offspring. The successive transitions between the different statuses of a given female give its individual reproductive trajectory. The performance of a given trajectory is assessed by its fitness which can be approximated by the total number of offspring weaned during the trajectory. Different individual life-history trajectories can exist in a same population and these different trajectories can reach similar or different fitness. This suggests that different strategies can be chosen by different individuals to reach the same fitness but also that individuals of high quality can reach higher fitness than individuals of low quality. The study of a roe deer population located in North-Eastern France allowed analyzing the sources and the consequences of individual heterogeneity on individual life-history trajectories and on population dynamics. This work showed that roe deer individual reproductive trajectories are consistent for a given female such as high quality females have an annual reproductive success higher than low-quality females. Female quality is partly generated by birth condition such as birth date and environmental conditions at birth. Individual life-history trajectories vary also randomly in relation to annual environmental conditions. In particular, climate change led to a decline in annual mean reproductive success and a decrease of the population growth rate in the last decades in relation to an increase of the mismatch between vegetation phenology and roe deer birth period. This work discussed how individual heterogeneity is generated in a long-lived species and how it influences individual life-history strategies and population dynamics
Barriers and Facilitators of Telemedicine Among Physicians at a University Hospital

Background and aims This study explored the perceived barriers and facilitators to the implementation of telemedicine among physicians and estimated and compared the prevalence of telemedicine use among physicians before and during coronavirus disease 2019 (COVID-19). Methods This cross-sectional study was conducted at King Saud University in Riyadh. A convenience sample of 163 physicians working at King Khalid University Hospital (KKUH) completed an online survey. Demographic data, patterns of use, and perceived barriers and facilitators of telemedicine were collected using a 5-point Likert scale. Results Our research showed that 61.3% (n = 100) of the physicians surveyed had used telemedicine in their careers. The prevalence of telemedicine before the onset of COVID-19 was 18.4%, whereas during COVID-19, it increased to 59.5%, which is an increase of 330% (P < .001). Most of the respondents (50.9%; n = 83) used it weekly (27%) or occasionally (23.9%). The most prevalent perceived barrier was technical difficulties (68.7%; n = 112), and the most prevalent perceived facilitator was that telemedicine can reduce unnecessary face-to-face appointments (86.5%; n = 141). Conclusion The use of telemedicine to provide health care is on the rise, especially in the case of emergencies. Different specialties face different facilitators and barriers, and the potential of telemedicine implementation depends on the work environment and the needs of the specialty. Several obstacles need to be overcome before telemedicine becomes a consistently used method for providing health care.
Targeted EGFR Nanotherapy in Non-Small Cell Lung Cancer

Non-small cell lung cancer (NSCLC) remains a leading cause of cancer-related mortality worldwide. Despite advances in treatment, the prognosis remains poor, highlighting the need for novel therapeutic strategies. The present review explores the potential of targeted epidermal growth factor receptor (EGFR) nanotherapy as an alternative treatment for NSCLC, showing that EGFR-targeted nanoparticles are efficiently taken up by NSCLC cells, leading to a significant reduction in tumor growth in mouse models. Consequently, we suggest that targeted EGFR nanotherapy could be an innovative treatment strategy for NSCLC; however, further studies are needed to optimize the nanoparticles and evaluate their safety and efficacy in clinical settings and human trials.
WASP - West Africa Swell Project - Final report and Appendices

The OGP Workshop on the Metocean and Engineering Aspects of Floating Systems which was held at St. Albans in April 2001 identified better discrimination of the low frequency end of the wave spectrum as one of the most pressing problems for the design and analysis of floating systems. The responses of many floating systems have proven to be very sensitive not only to the amplitude and frequency of the swell, but also to the details of the shape of the swell peak in the spectrum. There has been relatively little serious study of the low frequency end of the wave spectrum compared to the effort that has gone into the study of the high frequency tail of the spectrum. Much of the present interest in swell comes from the active deep water developments taking place off West Africa. The West African environment is generally mild, but swell from storms in the Southern Ocean is persistent and can reach fairly high amplitudes with very low periods. Enough data is now available so that a serious study of the characteristics of swell off West Africa can be made. In response to this need and opportunity, Shell Global Solutions, in association with Ifremer and Oceanweather, formed a Joint Industry Project to analyze and compare the available data on swell off West Africa. This report describes the results of that West Africa Swell Project (WASP).
Farewell to Farms

Introduction - de-agrarianization in Sub-Saharan Africa - acknowledging the inevitable. Part 1 Horn of Africa: coping with famine and poverty - the dynamics of non-agricultural rural employment in Darfur, Sudan farmers without land - the return of landlessness to rural Ethiopia. Part 2 West Africa: not by farming alone - the role of non-farm incomes in rural Hausaland winners and losers - household fortunes in the urban peripheries of Northern Nigeria economic activities of the poor in Accra. Part 3 East Africa: Urban trajectories in rural livelihood strategies - household employment patterns in kenya's Coast Province the rural information sector in Tanzania. Part 4 Southern Africa: non-farm activities and gender in Zimbabwe of livestock and deadstock: entrepreneurship and tradition on the South African Highveld. Part 5 Current policy issues: rural industries in Africa - hope and hype labour diversification in rurla Africa - implications for public works programmes. Conclusion - de-agrarianization, blessing or blight?
Interplay of diet and sympatry in the morphological evolution of noctilionoid bats

The remarkable ecomorphological diversity of the bat superfamily Noctilionoidea is the result of a diet‐mediated adaptive radiation. Stemming from a putatively insectivorous ancestor, noctilionoid bats diversified to adapt to the widest range of dietary ecologies among mammals. The high concentration of noctilionoid diversity in the Neotropics raises the question as to whether competitive ecological interactions influenced their diversification. However, patterns of morphological diversification along gradients of coexistence in Noctilionoidea are understudied. Here, we assessed the effect of dietary adaptations on patterns of morphological divergence associated with coexistence in noctilionoid bats.
Real-World Experiences with Taliglucerase Alfa Home Infusions for Patients with Gaucher Disease: A Global Cohort Study

Taliglucerase alfa is an enzyme replacement therapy approved for Gaucher disease. We assessed the duration/compliance/safety of such home infusions in commercial use in four countries where home infusion programs are available. The treatment duration/compliance study included 173 patients (Israel, 58; US, 61; Brazil, 48; Australia, 6) who received ≥1 taliglucerase alfa home infusion through 6/2021. The median age at home therapy initiation was 38 (range, 2–87) years; 58% were females. The median treatment duration (at home) was 2.7 (range, 0.04–9.0) years. The annual compliance rate was stable (≥95%) throughout the study period. A search of the Pfizer global safety database (through 6/2021), identified 19 adverse events (AEs) as related to “definite home use” and 14 to “possible home use” of taliglucerase alfa; 42.4% of these AEs were serious; none were fatal. Twelve serious AEs in five separate case reports were considered treatment related: one case of chest discomfort/pain and hypertension and one case of erythema associated with a toe blister, for which causality could not be excluded; pain in extremity; projectile vomiting and chills, alongside excessive eye blinking; and an infusion-related AE (pruritus). In conclusion, this real-life global study demonstrated that taliglucerase alfa home infusions are safe with high compliance rates.
Structure–Activity Relationships of Low Molecular Weight Alginate Oligosaccharide Therapy against Pseudomonas aeruginosa

Low molecular weight alginate oligosaccharides have been shown to exhibit anti-microbial activity against a range of multi-drug resistant bacteria, including Pseudomonas aeruginosa. Previous studies suggested that the disruption of calcium (Ca2+)–DNA binding within bacterial biofilms and dysregulation of quorum sensing (QS) were key factors in these observed effects. To further investigate the contribution of Ca2+ binding, G-block (OligoG) and M-block alginate oligosaccharides (OligoM) with comparable average size DPn 19 but contrasting Ca2+ binding properties were prepared. Fourier-transform infrared spectroscopy demonstrated prolonged binding of alginate oligosaccharides to the pseudomonal cell membrane even after hydrodynamic shear treatment. Molecular dynamics simulations and isothermal titration calorimetry revealed that OligoG exhibited stronger interactions with bacterial LPS than OligoM, although this difference was not mirrored by differential reductions in bacterial growth. While confocal laser scanning microscopy showed that both agents demonstrated similar dose-dependent reductions in biofilm formation, OligoG exhibited a stronger QS inhibitory effect and increased potentiation of the antibiotic azithromycin in minimum inhibitory concentration and biofilm assays. This study demonstrates that the anti-microbial effects of alginate oligosaccharides are not purely influenced by Ca2+-dependent processes but also by electrostatic interactions that are common to both G-block and M-block structures.
The Urban Challenge in Africa: Growth and Management of Its Large Cities

Scholars from a range of national and disciplinary backgrounds examine the growth of the largest cities in Africa--their characteristics, their dynamism despite economic crisis, and the results of attempts to manage them. The introductory chapters consider the effects of global forces on Africa and its major cities, revealing that the new phase of globalization has reinforced the continent's marginalization, impoverishment, indebtedness, and lack of policy autonomy, rather than leading to economic growth and diversification. Case studies of Cairo, Lagos, Johannesburg, Kinshasa, Abidjan, and Nairobi reflect the experience of the largest urban agglomerations; northern, southern, western, and eastern Africa; anglophone and francophone Africa; cities with an essentially domestic role and those with wider regional or continental roles; and cities on a continuum from relatively tight management to virtual collapse of public sector institutions. Each scholar examines economic and demographic trends; political, social, and physical characteristics; and arrangements for planning and management. The experiences of these and other cities are drawn upon in thematic chapters dealing with the characteristics of city economies, property markets, politics, governance, and social organization, and the lives of urban people; including migration patterns and the effects of impoverishment. The book shows that Africa's largest cities, even those in countries experiencing economic and state breakdown, will continue to grow and have vital economic roles. And while administrative systems have failed to cope and the institutional and financial capacity to deal with future growth is lacking, some more realisticand promising approaches to urban policy, planning, and management have emerged in recent years. The final chapters, therefore, are not entirely pessimistic about the continent's ability to rise to the urban challenge.
Determinan Factor that Affect The Intention to Use Sharia Financing: Piety as a Moderator

This study aims to determine the influence of the social environment, religious Awareness, profit margins, and ease of intention to use Sharia financing by using Piety as a moderation variable. The research method used is the quantitative method. The number of samples in this study was 94.04, rounded up to 100 respondents. Question indicators are measured using the Likert scale, which has five levels of preference, each of which is scored from 1 to 5. The results of the research obtained were processed using Smart-PLS. Based on the results of the analysis of research results using Smart-PLS, it shows that 1) The social environment does not have a positive and insignificant effect on the intention to use Islamic financing; 2) Religious Awareness has a positive and significant effect on the intention to use sharia financing; 3) Profit margins have no positive and insignificant effect on the intention to use financing; 4) Ease has a positive and significant influence with the intention to use Islamic financing that has significant results; 5) Piety has no positive and insignificant effect with the intention of using sharia financing whose results are insignificant; 6) Moderation Effect 1 has no positive and insignificant effect on the intention to use Islamic financing; 7) Moderation Effect 2 has no positive and insignificant influence on the intention to use Islamic financing; 8) Moderation Effect 3 has no positive and insignificant influence on the intention to use Islamic financing; 9) Moderation Effect 4 has no positive and insignificant influence on the intention to use Islamic financing.
Nonrelativistic and nonmagnetic terahertz-wave generation via ultrafast current control in anisotropic conductive heterostructures

Abstract. Precise and ultrafast control over photo-induced charge currents across nanoscale interfaces could lead to important applications in energy harvesting, ultrafast electronics, and coherent terahertz sources. Recent studies have shown that several relativistic mechanisms, including inverse spin-Hall effect, inverse Rashba–Edelstein effect, and inverse spin-orbit-torque effect, can convert longitudinally injected spin-polarized currents from magnetic materials to transverse charge currents, thereby harnessing these currents for terahertz generation. However, these mechanisms typically require external magnetic fields and exhibit limitations in terms of spin-polarization rates and efficiencies of relativistic spin-to-charge conversion. We present a nonrelativistic and nonmagnetic mechanism that directly utilizes the photoexcited high-density charge currents across the interface. We demonstrate that the electrical anisotropy of conductive oxides RuO2 and IrO2 can effectively deflect injected charge currents to the transverse direction, resulting in efficient and broadband terahertz radiation. Importantly, this mechanism has the potential to offer much higher conversion efficiency compared to previous methods, as conductive materials with large electrical anisotropy are readily available, whereas further increasing the spin-Hall angle of heavy-metal materials would be challenging. Our findings offer exciting possibilities for directly utilizing these photoexcited high-density currents across metallic interfaces for ultrafast electronics and terahertz spectroscopy.
Rehabilitation in a tropical secondary rain forest in Malaysian Borneo

Tropisk regnskog i Sydostasien ar ett av de omraden som hyser storst biodiversitet i varlden, av vilken stora ytor ar hotat. On Borneo drabbades av en katastrof aren 1982-1983 efter att vaderfenomenet El Nino orsakat torka med vidstrackta skogsbrander som foljd. Detta lamnade stora ytor av Borneos skogar i ett undermaligt, sekundart tillstand. Pa grund av detta startades INIKEA projektet med syfte att rehabilitera skogar i regionen kring Tawau vid ostkusten av delstaten Sabah i Malaysia. I denna studie undersokte jag resultatet av rehabiliteringsarbetet pa krontaket i tre olika skogstyper genom att ta hemisfariska foton med en digital systemkamera (DSLR). Vidare undersokte jag ytterligare tre metoder for att se deras lamplighet i denna typ av skog. Dessa var en sfarisk densiometer, det sa kallade Crown Illumination Index (CII) och hemisfariska foton tagna av en smartphone-kamera. Resultatet visade att skogstypen hade signifikant effekt pa variablerna visible sky och Leaf Area Index (LAI) medan rehabiliteringsmetoden hade signifikant effekt pa variablerna Direct Site Factor (DSF) och Global Site Factor (GSF). Smartphone fotona hade signifikant korrelation med sina motsvarande DSLR foton samt visade statistisk signifikans pa variablerna visible sky och LAI. Densiometern och CII har sina styrkor i att de ar enkla, snabba och latta att bara, de ar dock foremal for subjektivitet. Densiometern visade storst likhet med DSF och GSF medan CII visade signifikant korrelation med alla variabler forutom LAI.
Structure and tectonics of the southern Gebel Duwi area, Eastern Desert of Egypt

This study examines the Precambrian through.Tertiary tectonic elements of an area of about 350 square km the Red Sea coast utilizing geologic mapping petrofabric work. The resulting data are used to along and test ideas concerning faulting, stress history, and the effects of older anisotropies. The study area, Suez and 10 km inland from the Red Sea, 500 km south of contains the largest preserved remnants of late Cretaceous to early Tertiary cover along the Egyptian Red Sea coast. These 600 meter-thick platform sediments are preserved as outliers downfaulted along trends atypical of the Eastern Desert. Fault trends are most prominent in the northwesttrending, 40 km long Gebel Duwi fault block and appear to be reactivated Precambrian structures: the northwest-. striking, superimposed grain. Eocambrian Najd strike-slip fault zone upon a north-northwest Proterozoic fold Red Sea-related structures began to disrupt the area in Oligocene to early Miocene time; a pattern of small conjugate strike-slip faults of that age suggests N25E compression. The Tertiary faulting hierarchy involves a pattern of northeast-tilted, northwest-trending blocks terminating against older north-south zones with some