Miracle-dz/UniFAR-FTUs huggingface dataset:
The macho project first-year large magellanic cloud results: The microlensing rate and the nature of the galactic dark halo

Since July 1992, the MACHO project has been carrying out long-term photometric monitoring of over 20 million stars in the Magellanic Clouds and Galactic bulge. Our aim is to search for the very rare gravitational microlensing events predicted if the dark halo of our Galaxy is comprised of massive compact halo objects (hereafter MACHOs). We have now analyzed most of the first year{close_quote}s LMC data, comprising 9.5 million light curves of stars with an average of 235 observations each. Automated selection procedures applied to this sample show three events consistent with microlensing; the first detected is very striking (Alcock and coworkers), and two are of modest amplitude. We have evaluated our experimental detection efficiency using a range of detailed Monte Carlo simulations, including the addition of artificial stars to real data frames. Using a ``standard`` halo density profile, we find that a halo comprised entirely of MACHOs in the mass range 3{times}10{sup {minus}4} to 0.06 {ital M}{sub {circle_dot}} would predict more than 15 detected events in this data set, and objects around 3{times}10{sup {minus}3} {ital M}{sub {circle_dot}} would predict 25 events; thus a standard spherical halo cannot be dominated by objects in this mass range. Assuming all three events aremore » microlensing by halo objects, and fitting a naive spherical halo model to our data yields a MACHO halo fraction {ital f}=0.19{sup +0.16}{sub -0.10}, a total mass in MACHOs (inside 50 kpc) of 7.6{sup +6}{sub -4}{times}10{sup 10} {ital M}{sub {circle_dot}}, and a microlensing optical depth 8.8{sup +7}{sub -5}{times}10{sup -8} (68% confidence level). Should only one of these events be microlensing, this could be explained in terms of previously known populations. We have explored a wide range of halo models and find that, while our constraints on the MACHO fraction are quite model dependent, constraints on the total mass in MACHOs within 50 kpc are quite secure. « less
Mental Illness and Police Interactions in a Mid-Sized Canadian City: What the Data Do and Do Not Say

This study examines the quantity and nature of police interactions for people with mental illness in London, Ontario, Canada, in 2001. An algorithm designed for a police services administrative database was used to identify 817 people with mental illness and 111,095 people without mental illness. Charges and arrests were examined using 100 randomly selected records. People with mental illness had 3.1 more police interactions on average than the general population, and they were more frequently charged and arrested. As police officers became more familiar with the individuals, they were not much more likely to identify them as violent even when a person with mental illness had been a violent perpetrator.
Challenges and barriers to services for immigrant seniors in Canada: “you are among others but you feel alone”

Purpose – This paper seeks to explore varied interrelated challenges and barriers experienced by immigrant seniors.Design/methodology/approach – Senior immigrants representing diverse ethnicities (Chinese, Afro Caribbean, Former Yugoslavian, Spanish) described their challenges, support needs, and barriers to service access. Service providers and policy makers from organizations serving immigrant seniors were interviewed to elicit their views on barriers to access and appropriateness of services for immigrant seniors. Qualitative methods were employed to enhance understanding of meanings, perceptions, beliefs, values, and behaviors of immigrant seniors, and investigate sensitive issues experienced by vulnerable groups. The qualitative data were subjected to thematic content analysis.Findings – Seniors reported financial and language difficulties, health problems, discrimination, family conflicts, and social isolation. Although most immigrant seniors appreciated the standard of living in Canada and the serv.
Drug Utilization Patterns of Antimicrobial agents in the Outpatient department of ENT in a tertiary care teaching hospital of North India.

Abstract : Objective : To study the pattern of antimicrobial prescription in OPD of the department Otolaryngology in a tertiary care teaching hospital of North India. Materials and 32 00 patients, who visited the ENT OPD over a period of 12 months. Results : Out of 32were males and 40% (n=1035 years 60% (n=1560) while the geriatric group 76(n=50). 55% (n=1430) of patients were diagnosed with ear, 30% (n=764) with throat and 15% (n=296) with n 74.58 % (n= 2148) followed by Aminoglycosides agent in penicillins was a combination of amoxicillin and Clavulanic acid (11.97%), in Cephalos porins was Cefixime (41.59%) and in Aminoglycosides was Neomycin (9.72 %) respectively. Further, 69.11% of the patients received single antibacterial drug and the average number of antibacterial agents prescribed per patient per course was found to be 1.10concomitant medications antihistaminic were prescribed in 11.53%, Proton Pump Inhibitors in 20.38 % cases and NSAIDS in 7.26% cases. The average number of drugs used in each prescription was 2.70. None of the drugs were prescribed by generic name.prescription per day in OPD was Rs.45. Out of 2600 patients; culture sensitivity tests were performed for only 71 patients. Of which only 43 patients depicted a positive culture sensitivity tests. All the drugs were prescribed by theiadherence with the prescribed therapy.
Study of Fusion of Ischial Tuberosity in Gujarati Population by using Digital X-Ray Method

Forensic Medicine experts have to evaluate age in different medico legal situations, especially when the identity is not known, when the liability and punishment are related to the maturity. The study of epiphysial union of bones is considered a reasonable scientific and accepted method for estimation of age by the courts of law all over the world. The present study was carried out on 150 persons of age group between 17–21 years by using digital X-ray method in the Department of Forensic medicine and Toxicology at Govt. Medical College & New Civil Hospital, Surat.The present study possibly may generate the data giving shorter age intervals of fusion of centers of Ischial tuberosity (as compared to the standard text books or on the other end, may even positively reconfirm the evidential value of current data by using modern technique of digital X-ray). Anyhow, it will contribute to the better procurement and application of justice.
ANTI-ARTHRITIC POTENTIAL OF HELIANTHUS ANNUUS IN LABORATORY ANIMALS

Objective: The present study was carried out to investigate the anti-arthritic potential of ethanolic extract of Helianthus annuus leaves (HA). Methods: The effect of HA was evaluated for chronic inflammation by complete Freud’s adjuvant (CFA) induced arthritis in rats. Results: The paw edema was measured along with biochemical, hematological, histopathological, radiographic parameters, and ulcerogenic potential. In this study, pre-treatment with HA significantly decreased paw volume, arthritic index, spleen and thymus weight, ulcerogenic index; and inhibited histopathological changes in joint cavity and inhibited destruction of the knee joints induced by CFA in radiographic examination. Treatment of HA also restored significantly the hematological parameters such as hemoglobin level, total red blood cell, total white blood cell, and erythrocytsedimentation rate along with antioxidant parameters such as superoxide dismutase, catalase glutathione, and lipid peroxide. The serum marker of arthritis such as C-reactive protein (CRP) and rheumatoid factor were also reduced in the HA-treated arthritic rats. Conclusion: The results of the present study demonstrate the anti-arthritic potential of HA leaves in the anti-arthritic activity. Keywords: Anti-arthritic, C-reactive protein, Complete Freud’s adjuvant, Helianthus annuus, Paw volume, Rheumatoid factor.
I. IMPACT OF A GENETICS EDUCATION WORKSHOP ON FACULTY PARTICIPANTS II. INVESTIGATIONS OF UNDERGRADUATE GENETIC LITERACY

This research extends previous studies of undergraduate genetic literacy in two ways: (1) we assessed a 2006 undergraduate genetics education workshop for college faculty teaching genetics using three different measures. Based on participants’ feedback from immediate and long-term evaluations, we determined that the workshop was effective at meeting its objectives. However, meaningful conclusions regarding the workshops’ impact on course modifications and student learning could not be established due to limited data. (2) At one university, genetic literacy of biology majors was assessed, and compared with that of non-science majors, using two different instruments. The observed trendline was that increased biology experience yields increased genetic literacy; however the level of genetic literacy attained was lower than expected. Assuming the goals of these courses are consistent with our definition of genetic literacy, and how we measured it, the results suggest a need to modify both the content and pedagogy in these courses.
HIV in Asia: the way forward

The HIV epidemic in Asia and the rest of the world has continued unabated since it was confirmed as the cause of AIDS in 1981. While the continuous development of new and potent drugs has turned HIV into a chronic manageable disease, at least in the developed world, there is still work to be done. In resource-limited settings such as Thailand and most of Asia, key issues for the future include the appropriate use of the immunological and virological monitoring tools for patients on antiretroviral therapy and improved interventions for the prevention of mother to child transmission of HIV. This review examines the future challenges faced by physicians, researchers, HIV program managers and people living with and affected by HIV in the context of the Asian region.
The Current Molecular Site of the Myeloproliferative Neoplasms - TET-ÃÂ -tÃÂªte with the JAKpot but no LNK so far to Resolve Complexity

The myeloproliferative neoplasms essential thrombocythemia (ET), polycythemia vera (PV) and primary myelofibrosis (PMF) are clonal haematological stem cell disorders with different clinical courses and prognosis. The predominant feature in these entities is the overproduction of at least one cellular lineage in the bone marrow. Peripheral blood cells are terminally differentiated and functional but may affect e.g. blood viscosity with a high hematocrit in PV leading to the risk for thrombotic events or bleeding. PMF, preceded by a hypercellular pre-fibrotic stage, has the highest risk to develop manifest bone marrow fibrosis with consecutive bone marrow failure. The risk for a blast crisis and transformation into secondary acute leukemia is also particularly high in PMF and PV but rather uncommon in ET. Even though distinguishable from each other by clinical and histopathological criteria ET, PV and PMF may show overlaps, i.e. in early stages. Moreover, reactive hypercellular states in the bone marrow may mimic a myeloproliferative neoplasm (MPN) making definite molecular markers very useful. ET, PV and PMF currently share a number of molecular defects which are detectable by accurate technologies and, in a diagnostic sense, subsequently allow a clear-cut discriminationfrom reactive states. Some of these molecular defects are frequent in the stage of secondary acute leukemia; others were proposed to be potential predictors for a progression of the disease course. At best, the protagonist of molecular defects in Ph- MPN, the Janus Kinase 2 with its V617F mutation, became a therapeutic target by using small molecule inhibitors. This review focuses on the hitherto discovered molecular defects in ET, PV and PMF in chronic phase and disease progression, highlights some of the current and upcoming therapies and proposes a disease model.
Comparison of the effects of lecture and team based learning (TBL) on oral and maxillofacial pathology learning in dental students

Abstract The aim of this study was to compare the effects of lecture and team based learning (TBL) on oral and maxillofacial pathology learning in dental students. This quasi-experimental study was conducted in 30 dental students who applied for oral and maxillofacial pathology course in the School of Dentistry affiliated to Qazvin University of Medical Sciences during the first semester in 2013. The course was consisted of 10 one-hour sessions. Firstly, TBL was used in 5 continuous sessions. Then lecture was used in the remained sessions. In two sessions, multiple choices test was taken for both methods before and after the teaching and without prior notice. The mean difference of pre-test and post-test was 10.28 and 8 in the TBL and lecture, respectively and the difference was not statistically significant. With regards to the results, the effects of lecture and TBL on students’ learning are not significantly different.
The Impact of Continuous Patient Monitoring at Various Times of Day on In-hospital Cardiac Arrest Mortality

The Impact of Continuous Patient Monitoring at Various Times of Day on In-hospital Cardiac Arrest Mortality It is estimated that around 200000 treated in-hospital cardiac arrests occur annually in the United States, and this incidence may be increasing. Despite advances in management, unfavorable neurological outcomes and mortality remain high. Overall survival to hospital discharge is highly variable between studies, ranging from 0% to 42% with an estimated average in larger studies around 20% . Prior studies have demonstrated the association between criteria-defined abnormal vital signs on continuous monitoring and the incidence of cardiac arrest. The clinical benefit of monitoring on arrest outcomes was studied in a single-center study, with rates of survival to discharge in monitored wards arrests of 43.2% vs. 31.1% for non-monitored wards (p = 0.004).
Stress among Medical Students in the Deep South of Thailand

Medicine has been widely known as a high stress profession and medical school is often where stress begins. Identifying the common stressors among the medical students in our Medical Education Center, would help the supervisors to develop the suitable curriculum structure. This study aims to investigate the perceived sources of stress among 4th and 5th year medical student at Medical Education Center, Yala Hospital, Thailand, and to compare if the student with different gender, religion and study year perceives the source of stress differently. A descriptive cross sectional quantitative study was conducted using a 40 items self administered questionnaire adapted from the Medical Student Stressor Questionnaire (MSSQ). The determinants are gender, religion and the study year. T-test was used for analyzing the difference in group. A 92.73% response rate was obtained. The results indicated that falling behind in reading schedule, test and examination, large amount of content to be learnt, national test exam, and lack of time to review what have been learnt were the first five commonest stressors for students. Interestingly, the Muslim students had significantly higher total stress scores than Buddhist students, and the fifth year students had significantly higher stress than the fourth year students. In contrast, gender did not associated with the total stress scores. Medical instructor should design and develop a curriculum structure which is enhancing the student? s well being and focus on academic and clinical performance for producing graduates with a positive professional attitude.
Efficacy of preprocedural mouth rinse containing chlorine dioxide in reduction of viable bacterial count in dental aerosols during ultrasonic scaling: A double-blind, placebo-controlled clinical trial

Background: The risk to dentists, dental assistants, and patients of infectious diseases through aerosols has long been recognized. The aim of this study was to evaluate and compare the efficacy of commercially available preprocedural mouthrinses containing 0.2% chlorhexidine (CHX) gluconate, chlorine dioxide (ClO 2 ) mouthwash, and water in reducing the levels of viable bacteria in aerosols. Materials and Methods: This single-center, double-blind, placebo-controlled, three-group parallel-designed study was conducted over a period of 4 months. One hundred twenty patients with chronic periodontitis were divided randomly into three groups (A, B, and C) of 40 patients each to receive the ClO 2 mouthwash, water, and 0.2% CHX gluconate respectively as preprocedural rinse. The aerosol produced by the ultrasonic unit was collected at five standardized locations with respect to the reference point, i.e., the mouth of the patient. The blood agar plates were incubated at 37°C for 48 h, and the total number of colony-forming units (CFUs) was counted and statistically analyzed. Results: The results showed that CFUs in groups A and C were significantly reduced compared to group B, and P 0.05). The numbers of CFUs were the highest at the patient's chest area and lowest at the patient's front i.e., the 6 o'clock position. Conclusion: This study proves that a regular preprocedural mouthrinse could significantly eliminate the majority of aerosols generated by the use of an ultrasonic unit, and that ClO 2 mouthrinse was found to be statistically equally effective in reducing the aerosol contamination to 0.2% CHX gluconate.
Emotional Intelligence: An Empirical Study of Indian Managers in IT Industry

The present study is an assessment of gender difference in Emotional Intelligence (EI) among Indian managers in IT sector. The study was conducted in major IT hubs of India that include NCR (Noida, Delhi and Gurgaon), Pune & Bangaluru. The Emotional Intelligence (EI) of participants was evaluated through a structured questionnaire based on emotional intelligence competencies. The findings in this research study support the existence of a relationship between gender and emotional intelligence at leadership position.
Ultraviolet photometry from the orbiting astronomical observatory. 8: The blue Ap stars

The filter photometers in the Wisconsin Experiment Package on OAO-2 were used to obtain data for a carefully selected set of 24 blue Ap stars and 31 comparison standard B and A dwarfs and giants for a program of relative photometry. Observations were made in seven bandpasses over the effective wavelength range 1430A-4250A. The Ap stars observed include members of the Si, Hg-Mn and Sr-Cr-Eu peculiarity classes. Most of them are too blue in B-V for their published MK spectral classes. The blue Ap stars are markedly deficient in emitted ultraviolet flux and are underluminous as compared to normal stars with the same UBV colors. The Hg-Mn stars appear less flux deficient in the ultraviolet for their UBV colors than do Si or Sr-cr-Eu stars. Most of the Ap stars observed possess ultraviolet flux distributions, or ultraviolet color temperatures, consistent with their published MK spectral classes to well within the classification uncertainties.
Phase II of trastuzumab and cisplatin in patients (pts) with advanced gastric cancer (AGC) with HER2/neu overexpression/amplification

4613 Background: Trastuzumab(T) exhibits activity in human gastric cancer cells that overexpress HER2/neu. We previously reported a 13.5% HER2/neu overexpression/amplification in AGC or gastroesofageal junction (GEJ) cancers (Gravalos C, et al. J Clin Oncol 24, 18S, 200s, abstr # 4089). We designed a phase II trial to determine the efficacy and tolerability of T and cisplatin(C) in pts with ACG with HER2/neu overexpression/amplification. Exploratory objectives include analysis of c-erbB-2 extracellular domain and correlation of the results with histological erB-2/neu overexpression and with clinical response Methods: Chemo-naive pts with adenocarcinoma histopatologically confirmed, HER2/neu overexpression/amplification, measurable, no operable, locally advanced or metastatic AGC, age ≥ 18, ECOG ≤ 2, FEVI ≥ 50% and adequate organ function were eligible. Prior adjuvant radiotherapy or/and chemotherapy were allowed. Immunohistochemistry (IHC) was performed using herceptest. A fluorescence in situ hybridizati.
Palliative/end-of-life care in the newborn intensive care unit;

Advances in neonatal critical care in the past 3 decades have dramatically improved the life-saving capability of medical providers in the care of critically ill infants. However, a population of infants exists whose lives cannot be saved despite the most advanced medical therapies. Neonatal palliative/end-of-life care protocols provide guidance for medical providers in giving care to infants and their families at the end of life. This descriptive study deternlined the presence of palliative/end-of-life care protocols in two newborn intensive care units (NICUs). The study also explored the experiences and attitudes of NICU registered nurses (RNs) and neonatal nurse practitioners (NNPs) in providing care to infants at the end of life. This study served as a basis for exploring the current practices and attitudes of RN sand NNPs about neonatal end-of-life care in order to assess the need for the institution of a formalized palliative/end-of-life care protocol in these particular NICUs. An absence of palliative/end-of-life care protocols was found in both NICUs in this study. The majority of RNs and NNPs indicated that they believed the addition of a palliative/end-of-life care protocol would be at least sonlewhat helpful to them in providing care to infants and their families at the end of an infant's life. The respondents reported that providing palliative/end-of-life care was a positive experience overall. RNs with more years of NICU experience reported being more comfortable than RNs with fewer years of NICU experience in providing care to infants at the end of life. Comfort in providing care at the end of life was also increased with higher numbers of infants cared for at the end of life. Several common themes regarding RN and NNP perceptions of skills, concerns, and rewards in providing neonatal palliative/end-of-life care were found.
The effects of the selective estrogen receptor modulators MPP and raloxifene in normal and cancerous human and murine uterine tissue

The goal of this research was to determine the in vitro and in vivo effects of the Selective Estrogen Receptor Modulators (SERMs), methyl-piperidino-pyrazole (MPP), raloxifene, ICI 182,780 and 17β-estradiol on endometrial carcinoma cells in culture and on murine uterine tissue. These SERMs have been developed to target and understand the role of estrogen receptor action in estrogen-responsive organs. Based on their antagonistic actions, SERMs have both real and potential value in treating estrogenresponsive cancers, including endometrial cancer. The studies described herein verify that the SERMs MPP and raloxifene demonstrate partial agonistic effects in ovariectomized wild-type and ER-β knockout (ERβKO) mice but also induce apoptosis and proliferation in vitro in cultured endometrial cell lines, Ishikawa and RL-95. Thus, MPP and raloxifene exert apparently contrasting in vitro and in vivo effects due to their mixed agonist/antagonist action on murine uterine estrogen receptor in vivo. In addition to these data, I report gene expression changes in the uterus of mice treated individually or with the combination of 17β-estradiol and the SERMs, MPP, raloxifene, ICI 182,780 are