Miracle-dz/UniFAR-FTUs huggingface dataset:
Melanoma-reactive TCR-modified T Cells Generated in the Absence of Activation Retain a Less-differentiated Phenotype and Have Increased Therapeutic Potential.

Adoptive T cell therapy with T cell receptor (TCR)-modified T cells has shown promise in treating metastatic melanoma and other malignancies. However, studies are needed to improve the efficacy and durability of responses of TCR-modified T cells. Standard protocols for generating TCR-modified T cells involve activating T cells through CD3 stimulation to allow for the efficient transfer of tumor-reactive receptors with viral vectors. T cell activation results in terminal differentiation and shortening of telomeres, which are likely suboptimal for therapy. In these studies, we demonstrate efficient T cell transduction with the melanoma-reactive TIL1383I TCR through culturing with interleukin 7 (IL-7) in the absence of CD3 activation. The TIL1383I TCR-modified T cells generated following IL-7 culture were enriched with naïve (TN) and memory stem cell populations (TSCM) while maintaining longer telomere lengths. Furthermore, we demonstrated melanoma-reactivity of TIL1383I TCR-modified cells generated following IL-7 culture using in vitro assays and a superior response in an in vivo melanoma model. These results suggest that utilizing IL-7 to generate TCR-modified T cells in the absence of activation is a feasible strategy to improve adoptive T cell therapies for melanoma and other malignancies.
Seed Germination Response of Penstemon spp. To Gibberellic Acid

Treatment of seed with gibberellic acid (GA) resulted in significant increases in germination percent for Penstemon «mbiguus. P. jwarbatus P. catoni, P. palmeri. P. panyi. P. pseudospectabilis. P. secund{florus. and P. strictus in one or both of two experiments which were conducted. Germination of several other species increased with GA treatment, but differences were not significant. INTRODUCTION The genus Penstemon contains hundreds of species which produce very attractive flowers. In Arizona alone, about 40 species of Penstemon occur, at sites ranging from less than 1,500 feet to more than 10,000 feet in elevation. For such an attractive and widely adapted group of plants, the genus Penstemon is surprisingly little used in landscapes. One problem limiting use of these plants is seed germination. Germination may be poor (low final percent), slow or erratic. For P. parryi, a common lowelevation species in Arizona, Raeber (1) found that seed germination is greatly stimulated by treatment with gibberellic acid (GA). GA has also been reported to stimulate germination of many other species. The objective of this study was to determine whether seed germination of Penstemon species of the Western U.S. other than P. parryi could be stimulated with GA. MATERIALS AND METHODS The effect of gibberellic acid on seed germination of the 15 Penstemon species listed in Table I was studied. For each species, 25 seeds were placed on top of two layers of Whatman #1 filter paper in a 9 cm plastic petri dish, and then 4 ml of either distilled water or a 100 ppm solution of gibberellic acid (GA) was added. Three dishes were prepared for each of the two treatments for each of the species. The petri dishes were randomized on trays and enclosed in a polyethylene bag to prevent drying. Seeds were incubated in the dark at 20°C in a germinator. Germination counts were made starting day 4 and made approximately every 2 days thereafter. Results for day 8 are given in Table 1. The entire study was repeated. In the repetition, only 10 seeds were used for each replicate of P. cobaea, 25 seeds were used for all other species. Germination results for day 7 are given in Table 1.
AGARD standard aeroelastic configurations for dynamic response

Since emphasis is on the transonic speed range, special importance is placed on configurations for which available data are sufficient to define accurately a transonic flutter boundary. Only configurations with clean, smooth surfaces are considered suitable. Segmented models or models with surface-slope discontinuities are inappropriate. Excluded also, in general, are configurations and data sets that involve behavior that is uncertain or not well understood, uncertain model properties, or know sensitivities to small variations in model properties. In order to assess the suitability of configurations already tested and the associated data for designation as standard, a survey of AGARD member countries was conducted to seek candidates for the prospective set. The results of that survey are given and summarized along with the initial selection of a standard configuration.
Methods for In-Flight Wing Shape Predictions of Highly Flexible Unmanned Aerial Vehicles: Formulation of Ko Displacement Theory

The Ko displacement theory is formulated for a cantilever tubular wing spar under bending, torsion, and combined bending and torsion loading. The Ko displacement equations are expressed in terms of strains measured at multiple sensing stations equally spaced on the surface of the wing spar. The bending and distortion strain data can then be input to the displacement equations to calculate slopes, deflections, and cross-sectional twist angles of the wing spar at the strain-sensing stations for generating the deformed shapes of flexible aircraft wing spars. The displacement equations have been successfully validated for accuracy by finite-element analysis. The Ko displacement theory that has been formulated could also be applied to calculate the deformed shape of simple and tapered beams, plates, and tapered cantilever wing boxes. The Ko displacement theory and associated strain-sensing system (such as fiber optic sensors) form a powerful tool for in-flight deformation monitoring of flexible wings and tails, such as those often employed on unmanned aerial vehicles. Ultimately, the calculated displacement data can be visually displayed in real time to the ground-based pilot for monitoring the deformed shape of unmanned aerial vehicles during flight.
Development of a Multiple Contact Haptic Display with Texture-Enhanced Graphics

: This dissertation presents work towards the development of a multiple finger, worn, dynamic display device, which utilizes a method of texture encoded information to haptically render graphical images for individuals who are blind or visually impaired. The device interacts directly with the computer screen, using the colors and patterns displayed by the image as a means to encode complex patterns of vibrotactile output, generating the texture feedback to render the image. In turn, the texture feedback was methodically designed to enable parallel processing of certain coarse information, speeding up the exploration of the diagram and improving user performance. The design choices were validated when individuals who are blind or visually impaired, using the multi-fingered display system, performed three-times better using textured image representations versus outline representations. Furthermore, in an open-ended object identification task, the display device saw on average two-times better performance accuracy than that previously observed for raised-line diagrams, the current standard for tactile diagrams.
Timetable management technique in railway capacity analysis: Development of the Hybrid Optimization of Train Schedules (HOTS) model

xxiv Introduction . xxv Research Background. xxv Timetable Management . xxvi Research Objectives and Methodology . xxxi 1Railroad Capacity Tools and Methodologies in the U.S. and Europe . 1 1-1Abstract . 2 1-2Introduction . 3 1-3What is Capacity? 4 1-3-1Capacity Concept and Definitions. 4 1-3-2Capacity Metrics . 8 1-4Differences between the U.S. and European Rail Systems . 8 1-4-1Infrastructure Characteristics . 9 1-4-2Signaling Characteristics . 10 iv 1-4-3Operation Characteristics . 10 1-4-4Rolling Stock Characteristics . 11 1-5Capacity Measurement, Analytical, Simulation and Combined Approaches . 12 1-5-1Analytical Approach . 13 1-5-2Simulation Approach . 15 1-5-3Combined Analytical-Simulation Approach . 21 1-6Review of Capacity Studies in the U.S. and Europe . 22 1-6-1Studies with Analytical Approach . 22 1-6-2Studies with Simulation and Combined Approach . 24 1-6-3Detailed Assessment of Selected Studies . 28 1-7Summary and Conclusions . 30 1-8References . 32 2. Hybrid Simulation Approach for Improving Railway Capacity and Train Schedules . 38 2-1Abstract . 39 2-2Introduction . 40 2-3Capacity Analysis . 41 2-4Hybrid Simulation Approach . 45 2-5Case Study . 48 2-6Outcomes and Discussion . 51 2-6-1Replicating Initial Timetable . 51 2-6-2Timetable Improvement . 55 2-6-3Additional Capacity Provided by Compression Technique . 60 2-6-4Validation of Improved Timetable . 62 v 2-7Summary and Conclusions . 65 2-8Acknowledgments . 66 2-9References . 66 3. Evaluating Two Capacity Simulation Tools on Shared-use U.S. Rail Corridor . 69 3-1Abstract . 70 3-2Introduction . 71 3-3Review of Capacity Methodologies and Tools . 73 3-4Case Study of the U.S. Shared-Use Corridor. 74 3-4-1Objective. 74 3-4-2Review of Case Study Characteristics . 75 3-5Capacity Analysis, Review of Train Timetable . 78 3-5-1Brief Introduction of Applied Tools . 78 3-5-2Outcomes of RTC Simulation . 81 3-5-3Outcomes of RailSys Simulation . 82 3-6Capacity Analysis and Applying Timetable Compression Technique on the Case Study 84 3-6-1Scenario 1: New Freight Train . 85 3-6-2Scenario 2: Timetable Compression Technique . 87 3-7Conclusions and Next Steps of Research . 90 3-8Acknowledgments . 93 3-9References . 93 4. Capacity Evaluation of Directional and Non-directional Operational Scenarios along a Multiple-Track U.S. Corridor . 96
Does Facebook ‘threaten’ romantic relationships? Online surveillance and couple visibility behaviours in romantic jealousy and couple relationship quality in a sample of Italian women

ABSTRACT Facebook has been identified as one of the most influential social network site (SNS) in the formation, maintenance and interruption of romantic relationships. Over the last decade, several studies have been carried out on Facebook and romantic relationships; however, there is still lack of evidence on how the reciprocal perceptions of partners’ behaviours on Facebook relate with couple relationship quality. This study aimed to fill this gap examing whether and to what extent participants’ surveillance and visibility behaviour related with the perception of their partner’s surveillance and visibility behaviour, and to what extent this perception related with both romantic jealousy and relationship quality. A sample of 635 heterosexual women having a romantic relationship participated in a study, which consisted of answering an online questionnaire with items on both the participants’ and their partner’s online behaviour. Path analyses were used for testing the hypotheses. Results showed that Facebook supported behaviours that can affect the quality of romantic relationship. Contrary to what expected, both online surveillance and couple visibility positively related with romantic jealousy, which in turn mediated the relation between surveillance and relationship quality, thereby worsening the participants’ perception of couple relationship quality.
INFLUENCING DRIVER BEHAVIOUR AND SAFETY BY ROAD SYSTEM IMPROVEMENTS

On the basis of a literature survey, the issue of influencing driver behavior by a user based approach to road design and driver information is discussed. The importance of considering driver information needs and cognitive capacities and limitations is focused. Road layout, signs and markings should be in accordance with driver expectations, to avoid errors and increased crash risk. Special topics discussed include effects of road design on speed, the risk of wrong way driving, criteria for optimal direction signing, and how the road system should better accommodate the information needs of elderly drivers.
NONDESTRUCTIVE EVALUATION FOR BRIDGE MANAGEMENT IN THE NEXT CENTURY

This article describes the Federal Highway Administration's (FHWA's) program of research and development in nondestructive evaluation of the nation's bridges. The program is currently focusing on developing technologies to address a wide range of problems. One focus area is the detection and evaluation of fatigue cracks in steel highway bridges. Another area is developing technologies for the rapid and quantitative evaluation of reinforced concrete bridge decks covered with bituminous concrete. This article summarizes FHWA's current research and development program, highlighting the program objectives, background, advanced bridge deck inspection technology, advanced-bridge-testing and health-monitoring projects, advanced fatigue-crack detection and evaluation projects, advanced corrosion detection and evaluation projects, and other advanced nondestructive evaluation projects. The program of research and development is helping to ensure the safety of the nation's bridges and providing more accurate and complete information about the condition of the nation's highway bridges.
Detection capability of Actinic Blank Inspection tool

A high volume manufacturing (HVM) model of EUV Actinic Blank Inspection (ABI) tool has been developed for the purpose of detecting phase defects on EUV masks. Simulation has been carried out as to how defect aspect ratio (height/width) and illumination numerical aperture (NA) affect defect signal intensity (DSI). It shows that a higher illumination NA leads to a higher DSI for defects with low-aspect ratios. For example, if the illumination NA is changed from 0.07 to 0.1, DSI is expected to increase 20% or more for defects with an aspect ratio lower than 0.015. The ABI tool has shown an enhanced sensitivity, especially for low-aspect ratio defects, after its NA illumination is raised from its original 0.07 NA to 0.1 NA. Actual inspection results using programmed-defect masks show that DSI has increased significantly for defects with low aspect ratios while the signal intensities for defects with high aspect ratios remain the same.
Interim noise correlation for some OTW configurations using external jet-flow deflectors. [engine Over The Wing

Jet flap interaction acoustic data obtained statically from a model-scale study of STOL-OTW configurations with a conical nozzle mounted above the wing and using various external deflectors to provide jet-flow attachment are correlated. The acoustic data are correlated in terms that consider the jet/flap interaction noise contributions associated primarily with fluctuating lift, trailing edge, and configuration wake noise sources. Variables considered include deflector geometry, flap setting and wing size. Finally, the configuration overall noise levels are related to static lift and thrust measurements in order to provide insight into possible acoustic/aerodynamic performance trade-off benefits.
Load Sharing Mechanism of Piled-Raft Foundation in Sand

The application of piled raft foundations for supporting high rise buildings has significantly increased over the last few years. The economic benefits of piled raft foundations in comparison with alternative approaches have encouraged this popularity, but this comes with additional complexity for load sharing calculations in a multi-parameter problem. These parameters are, but not limited to: soil density, pile length, pile spacing, raft geometry, and pile installation technique. The complexity of piled raft foundation design demands further research in a range of different engineering aspects. In this study, the load sharing mechanism of a piled raft foundation in sandy soil was investigated through small scale tests and three dimensional numerical analyses. The effects of density in homogeneous and layered soil, sand particle size distribution, pile installation method, and raft width were studied through experimental analyses. Experimental tests were performed on a shallow footing, single pile and single piled raft unit in clean Silica sand. The results of small scale tests reveal that soil density changes the load sharing mechanism of a displacement piled raft—the pile share increases in denser soil. However, this result does not hold in non-displacement piled rafts where load sharing is independent of soil density. Furthermore, it is observed that particle size distribution has inconsiderable effects on piled raft behavior. One of the experimental tests on non-displacement piled rafts was employed to calibrate the 3D numerical model, which was further expanded into 2x2 and 3x3 piled raft foundations. The load sharing outputs of the aforementioned models were compared for a given settlement ratio. This comparison reveals that the number of piles has an inconsiderable impact on the load sharing of non-displacement piled raft given that the piles are identical in size and a minimum spacing among them is respected. The numerical analysis confirms that the conducted experimental tests on non-displacement piled rafts are applicable to predict the load sharing in practical cases. Therefore, an empirical model was developed to achieve this goal under various settlement ratio and pile spacing. The proposed empirical models were validated against the available centrifuge and field test results in the literature. A widely accepted analytical model in the literature was modified based on the previously conducted experimental results. The proposed model calculates the load sharing as a function of settlement and pile spacing ratio in homogeneous and layers soils.
Post-Transplant Diarrhea is Associated with Increased Rejection in Lung Transplant Recipients: A Retrospective Review

Background Diarrhea causes significant morbidity among solid organ transplant recipients. It is described in liver and kidney transplant recipients, but not in lung transplant (LTx) recipients. The primary aim of this study was to characterize diarrhea in LTx recipients. Methods Retrospective review was performed for all patients undergoing LTx at our tertiary care hospital between 01/2011 and 02/2019. Electronic medical records were reviewed for the development of diarrhea. Results A total of 564 patients (66.3% male, mean age 64.4 ± 8.8 years) underwent LTx during the 8-year study period, with 289 patients (51.2%) experiencing post-LTx diarrhea. The most common etiologies of diarrhea were medication-induced (33.6%) and CDI (15.6%). Mycophenolate mofetil (MMF) was the most common cause of medication induced diarrhea (33.3%). Diarrhea and age were significantly associated with increased LTx rejection rates in multivariate analysis (Diarrhea OR = 2.26, 95% CI = 1.48–3.45; Age OR = 0.98, 95% CI = 0.95-1.0). Conclusions Diarrhea is common in LTx recipients, with medication-induced diarrhea being the most common etiology. Diarrhea and younger age were associated with an increased risk of LTx rejection. Recognizing the causes of diarrhea in LTx recipients is important for early diagnosis and treatment, leading to greater quality of life and improved graft function.
Comparing risk maps and star ratings

The AusRAP Star Ratings initiative was launched by the Australian Automobile Association in October 2006 following over two years of research, development and assessment. The Star Rating results are based on an assessment of the engineering features of the road network and the calculation of a Road Protection Score (RPS). This report details an investigation into the relationship between the Star Ratings/RPS and the crash costs on the road network. While the AusRAP model is not a crash prediction tool a link between the Star Ratings/RPS and crash outcomes is expected. The study involved the comparison of crash data and Star Rating/RPS results on the Queensland AusLink network assessed as part of the 2006 report. The analysis provides a strong indication of the improvement in crash costs that can be expected as a road network improves from two star to three star to four star and ultimately a five star road. These results are expected to assist in further work being undertaken during 2007/2008 to investigate the expected economic costs and benefits of raising the AusLink network to a four star standard.
An Analysis of Scientific Articles on Science Misconceptions: A Bibliometric Research

The aim of the study is to conduct a bibliometric analysis of the published articles related to science misconceptions. For this purpose, bibliometric analyses have been carried out with 859 articles published in physics, chemistry, and biology education between 1986 and 2019. The articles have been obtained through Web of Science Core Collection database using “science misconceptions” keyword and the tendencies in the last 33 years are presented. The selected articles were put through bibliometric analysis to identify the results for the annual distributions of the articles; the average citation scores; the list of the journals that published the highest number of related articles; the list of the authors that had published the highest number of related articles; the citation burst scores of the authors; the scientific productivity of the countries of the authors; the articles that were cited at the highest rates; collaboration networks; and their patterns that were obtained through text mining methods of word cloud and word tree. The results indicate that there has been an increase in the interest in science misconceptions after 2010. The journal that has the highest number of publications on the issue is found to be Journal of Science Education while David F. Treagust is identified to have the highest number of articles published on the topic so far. The article that has been cited the highest is Furtak’s article published in 2012. The findings also show that Korea and China are the countries that are open to collaboration the most and that the most frequently used keywords are determined to be “science” and “students”. The results are meant to guide researchers in the field in their future studies.
EXPERIMENTAL INVESTIGATION TO INFORM OPTIMAL CONFIGURATIONS FOR DYNAMIC NEAR-FIELD PASSIVE UHF RFID SYSTEMS

OF THESIS EXPERIMENTAL INVESTIGATION TO INFORM OPTIMAL CONFIGURATIONS FOR DYNAMIC NEAR-FIELD PASSIVE UHF RFID SYSTEMS RFID has been characterized as a “disruptive technology” that has the potential to revolutionize numerous key sectors. A key advantage of passive RFID applications is the ability to wirelessly transmit automatic identification and related information using very little power. This paper presents an experimental investigation to inform the optimal configuration for programming passive ultra-high frequency (UHF) RFID media in dynamic applications. Dynamic programming solutions must be designed around the tag’s functionality, the physical programming configuration and environment. In this investigation, we present a methodology to determine an optimal configuration to maximize the systems programming efficiency for dynamic applications.
Effect of Sawdust Particle Size on Physical, Mechanical, and Energetic Properties of Pinus durangensis Briquettes

Particle size is a physical property that sometimes limits the quality of briquettes, so it is recommended to use different sizes in mixtures for their manufacture. The objective of this research was to evaluate the effect of different particle sizes of sawdust in mixtures on some physical, mechanical, and energetic properties of briquettes made from Pinus durangensis sawdust, as well as set the ranges within the appropriate values found to obtain desired values. Three particle sizes were established (large, medium, and small), and 10 mixtures were prepared using different percentages of each particle classification. The particle density, volumetric swelling, compressive strength, impact resistance index (IRI), and gross calorific value of the briquettes were evaluated. For the determination of optimal mixtures, the surface response methodology was used under a three-factor simplex-lattice model. The particle density values were in the range 0.92 to 1.02 g cm−3 and the volumetric swelling was 0.96 to 3.9%. The highest resistance to compression was 37.01 N mm−1, and the IRI was found in the range of 53 to 107%. The gross calorific values were from 19.35 to 21.63 MJ kg−1. The selection of different particle sizes for the mixtures increases the quality of the briquettes.