Miracle-dz/UniFAR-FTUs huggingface dataset:
Multi Epitope Vaccine Candidate against Mycobacterium Tuberculosis

Tuberculosis or TB is a disease caused by a type of bacteria called Mycobacterium tuberculosis that mainly affects the lungs, even though other tissues and organs may be involved. The present study aims to choose and analyze different epitopes of Apa, PstS3, SecA2, and RD1 using bioinformatics analysis and software. After that molecular docking assay was used to recognize the binding energy and affinity of designed epitopes to HLA-A0201. The vaxiJen score of these sequences were 0.5233, 0.8066, 0.5008, and 0.5512 respectively. B-cell epitopes were predicted using IEDB and Vaxign webserver was used to prediction of binding of peptides to MHC class-I. Physicochemical analysis of vaccine showed that the molecular weight of candidate vaccine is 54.331kDa with the half-life of 30 hours in mammalian reticulocytes, greater than 20 hours for yeast, and greater than 10 hours for Escherichia coli . The chemical formula of vaccine was C 2410 H 3750 N 648 O 747 S 18 and theoretical pI of candidate vaccine was 5.85. There are 496 amino acids in the protein structure of which 67 residues with negative charge (Asp + Glu) and 63 (Arg + Lys) residues are negative charge. The instability index, aliphatic index, and grand average of hydropathicity of candidate vaccine were 27.44, 67.46, and -0.521 respectively. According to the result of protparam and pepcalc analysis, the vaccine is soluble in water. Parabi analysis showed that the membrane helices value of vaccine was 25.2%. The vaccine does not have more transmembrane helix, therefore no expression difficulties are predicted in the production of vaccine. 3Drefine was used to minimize and correct the hypothetical structure. Ramachandran plot analysis by procheck showed that 96.3% of residues are in most favored regions, 3.7% of residues are additional allowed regions and 0% of residues is in disallowed regions. Molecular docking result of this research revealed that our designed vaccine can stimulate HLA0210. The vaccine may activate humoral and cellular immune responses against of Mycobacterium tuberculosis . However, the vaccine could be cloned and expressed in different host cells.
Self-control in the monkey Macacafascicularis

Two experiments tested two cynomolgus monkeys' self-control-choice of a longer, more delayed reinforcer over a shorter, less delayed reinforcer. In Experiment 1, subjects exhibited significant self control in a procedure in which reinforcer amounts and delays were held constant throughout a con dition. In Experiment 2, subjects exhibited significantly greater sensitivity to variation in reinforcer amount than to variation in reinforcer delay in a procedure in which the reinforcer delay associated with the self-control alternative was adjusted until each macaque was indifferentbetween the two alter natives. Both experiments indicated that, in laboratory paradigms in which humans show self-control and pigeons and rats show impulsiveness, macaques show self-control. These results are inconsistent with the hypothesis that species differences in self-control are a function of language ability or of spe cific types of prior training. The results are consistent with the hypothesis that species differences in self-control are related to the ratio of brain size to body weight (a possible indicator of general cogni tive ability) or to shared phylogeny.
The First Crystal Structure of Archaeal Aldolase UNIQUE TETRAMERIC STRUCTURE of 2-DEOXY- D -RIBOSE-5-PHOSPHATE ALDOLASE FROM THE HYPERTHERMOPHILIC ARCHAEA Aeropyrum

A gene encoding a 2-deoxy- D -ribose-5-phosphate aldo- lase (DERA) homolog was identified in the hyperthermophilic Archaea Aeropyrum pernix. The gene was over-expressed in Escherichia coli , and the produced enzyme was purified and characterized. The enzyme is an extremely thermostable DERA; its activity was not lost after incubation at 100 °C for 10 min. The enzyme has a molecular mass of (cid:1) 93 kDa and consists of four subunits with an identical molecular mass of 24 kDa. This is the first report of the presence of tetrameric DERA. The three-dimensional structure of the enzyme was determined by x-ray analysis. The subunit folds into an (cid:1) / (cid:2) barrel. The asymmetric unit consists of two homologous subunits, and a crystallographic 2-fold
Evidence from Rice Farmers in Eastern India

provides research-based policy solutions to sustainably reduce poverty and end hunger and malnutrition. IFPRI’s strategic research aims to foster a climate-resilient and sustainable food supply; promote healthy diets and nutrition for all; build inclusive and efficient markets, trade systems, and food industries; transform agricultural and rural economies; and strengthen institutions and governance. Gender is integrated in all the Institute’s work. Partnerships, communications, capacity strengthening, and data and knowledge management are essential components to translate IFPRI’s research from action to impact. The Institute’s regional and country programs play a critical role in responding to demand for food policy research and in delivering holistic support for country-led development. IFPRI collaborates with partners around the world. Abstract The paper explores the spread of crop insurance in India and analyzes the factors affecting the demand for crop insurance. The study also assesses the impact of crop insurance on the rice yields of smallholder rice producers. Using data from a large farm-level survey from eastern India, the study tests for robustness of the findings after controlling for other covariates and endogeneity, using propensity score matching, coarsened exact matching, and endogenous switching regression models. Results indicate a positive and significant impact of crop insurance on rice yields.
A Case of Primary Multiple Myeloma

We report a case of 77-year-old woman who presented with lumbago and hypercalcemia. Multiple myeloma (MM) was first diagnosed by serum protein electrophoresis and bone marrow aspiration, but intact parathyroid hormone (intactPTH) was also found to be high in the presence of persistent hypercalcemia with anorexia and nausea. After lowering serum calcium with bisphosphonate administration, parathyroidectomy was performed. Upon histologic examination, the tumor was determined to be parathyroidal chief-cell hyperplasia and the patient was treated with melphalan and prednisolone. The relationship between MM and primary hyperparathyroidism (I°HPT) remains unknown. Although the co-existence of MM and I°HPT was reported in 12 reports from various parts of the world, there was only 1 report in Japan. The present case is an example of successful treatment for a complicated disorder, and suggests that patients suffering from bone pain or hypercalcemia need to be examined both endocrinologically and hematologically.
First molecular identiFication oF Gerbillus amoenus (rodentia, muridae) in morocco

The taxonomic status of the gerbil Gerbillus amoenus in relation to Gerbillus nanus and the distribution range of these two species in Africa and/or Asia have long been debated and are not yet fully clarified. In our study, we identify two specimens of small gerbils that we captured in two localities of the south of Morocco, using morphometric and/or molecular tools. The body and skull measurements were not able to unambiguously discriminate between three closely related small gerbils ( Gerbillus amoenus , Gerbillus nanus and Gerbillus henleyi ). However, the cytochrome b gene analysis showed that our two specimens cluster unambiguously with haplotypes of G. amoenus . This represents the first genetic characterization of G. amoenus in Morocco. It confirms, based on mitochondrial DNA, that the previously described species living in Africa is indeed G. amoenus and not G. nanus, the latter species being present strictly in Asia.
the and impact of risk scores on long-term outcomes in CKD patients. MitraClip in High- Versus Low-Volume Centers

We thank Lozano and colleagues for their interest in this subject, and agree that the limited use of potent antiplatelet therapies in high-risk patients with chronic kidney disease (CKD) is a concern. In the PROMETHEUS study, prasugrel was not superior to clopidogrel, very likely on account of the selection bias for prescription of potent therapies (1). This bias in observational studies also obscures the ability to detect therapeutic toxicity with respect to bleeding, which contrasts with findings from randomized trials (2,3). In the PLATO (Platelet Inhibition and Patient Outcomes) trial, patients with CrCl <30 ml/min had significantly greater bleeding with ticagrelor than clopidogrel (23.6% vs. 14.1%) (4). We also concur with the commentary from Gurm, especially his views regarding ticagrelor (5). However, cautious interpretation is necessary because although consistent treatment effects were observed with ticagrelor versus clopidogrel in CKD and non-CKD patients when using creatinine clearance, a treatment interaction was noted when using the more robust Modification of Diet in Renal Disease equation definition, both for the primary endpoint as well as for all-cause mortality (6). Whether or not these differences reflect a biological mechanism versus selection of higher-risk patients with renal impairment remains unclear. Although the morbidity of bleeding cannot be underestimated, improved selection for potent therapies is warranted. This may be done with the usage of thrombotic and bleeding risk scores (7), and plausibly with a case-by-case decision for assessment of platelet reactivity for identification of CKD patients at lower risk of bleeding (8), who may then be selected for potent therapies. Future studies are necessary to examine the uptake and impact of risk scores on longterm outcomes in CKD patients.
Autoimmune hepatitis in India: single tertiary referral centre experience

Background and Aims: Autoimmune hepatitis is considered to be rare in Asia-Pacific region. There a few long term studies available. This study was planned to estimate the burden, natural history of AIH and challenges associated with management in a single non-transplant tertiary referral center. Methods: Prospectively maintained data of patients treated as AIH was screened and patients who qualified AIH by retrospective application of simplified criteria's were enrolled. 181 patients qualified. 125 patients with substantial follow up (65 Definite AIH; 81 females; median age 46, range 8 - 79) were included in study. Results: Prevalence of AIH was 1.3% and 8.74% amongst all liver disease patients and chronic liver disease respectively. 89 patients qualified as Type I AIH, 14 as type II AIH and 22 were autoimmune markers negative. Modes of presentation was acute liver failure (n=8), chronic hepatitis (n=17), cirrhosis (n=89), 50 patients were decompensated), ACLF (n=7), while 2 were clinically asymptomatic. 19 patients had preceding history of drug intake. 33 patients didn't undergo pretreatment liver biopsy. Prednisolone alone was the predominant immunosuppressive agent used, especially in decompensated cirrhotics and those with acute liver failure. First remission rates after first immunosuppression course were 60%, 85% and 63% in type I, type II and autoantibody negative groups. After a median follow up of 7 years (range 1 - 17 years), 15 patients died (12 of liver related complications) and 2 underwent liver transplantation. Failure to normalize ALT had a high hazard ratio predicting liver related death or transplantation. 11 patients had improvement on repeat liver biopsy, with 5 showing complete cirrhosis reversal. 40 patients are on long term maintenance immunosuppression. Conclusion: AIH, though uncommon, needs to be kept in mind as early treatment is associated with significantly good long term prognosis.
Respons Tanaman Bawang Merah Asal Biji True Shallot Seeds terhadap Kerapatan Tanaman pada Musim Hujan

Kerapatan tanaman merupakan salah satu faktor yang dapat memengaruhi produksi umbi bawang merah asal true shallots seed (TSS) pada musim hujan (off-season). Tujuan penelitian ialah menentukan kerapatan tanaman yang sesuai untuk produksi umbi beberapa varietas bawang merah dari TSS. Penelitian dilakukan di lahan petani di dataran rendah Cirebon, dari bulan November 2010 sampai dengan Februari 2011. Rancangan percobaan yang digunakan ialah acak kelompok pola faktorial, dengan dua faktor dan empat ulangan. Faktor pertama ialah tanaman asal TSS beberapa varietas bawang merah, yaitu Allium ascalonicum cv. Maja, Bima, dan Tuk-Tuk sebagai pembanding. Faktor kedua ialah kerapatan tanaman, yaitu 100 dan 150 tanaman per m2. Hasil penelitian menunjukkan bahwa tidak terjadi interaksi antara varietas dan kerapatan tanaman terhadap pertumbuhan dan hasil umbi bawang merah asal TSS. Varietas dan kerapatan tanaman tidak berpengaruh terhadap pertumbuhan dan hasil umbi bawang merah asal TSS, tetapi berpengaruh terhadap jumlah tanaman yang dapat dipanen umbinya. Varietas Tuk-Tuk sebagai pembanding dan kerapatan tanaman yang tinggi (150 tanaman per m2) menunjukkan jumlah tanaman yang dapat dipanen paling sedikit. Hasil umbi kering asal TSS paling tinggi diperoleh pada A. ascalonicum cv. varietas Maja dengan kerapatan 100 tanaman/m2, yaitu sebesar 5,15 t/ha. Hasil penelitian ini diharapkan bermanfaat bagi pengguna untuk meningkatkan produktivitas dan kualitas umbi bawang merah pada musim hujan.
Practical ship weather routeing for liquefied natural gas carriers

The research developed a realistic model which encompasses the ship routeing process, weather prediction methods, ship environment interaction and route optimization algorithm. The optimization models were constructed for Tenaga Class Liquefied Natural Gas Carriers (LNGC) using minimum time, minimum fuel consumption or combination of both as objective functions. The ship service performance data which was derived from the analysis of actual records of her past voyages are incorporated in the ship routeing algorithm. The data has enabled a good comparison between simulations and actual results. Ship routeing simulation based on two methods i.e. standard route and simplified shortest path algorithm was performed and the outcomes have demonstrated the economic and safety benefits. The results indicate that potential cost saving is high likely and optimum benefit is not fully acquired by the current standard route practice. Ship routeing may generate savings in terms of both time and fuel consumption. Furthermore, it was found that a shorter distance route is not necessarily an optimal solution. The optimal solution arise from the consideration of all aspects i.e. dynamic weather changes, voyage optimization, model constraints and objective function.
Abant Tıp Dergisi İdiopatik Parkinson Hastalığında Dürtüsellik: Eşleştirilmiş Vaka Kontrol Çalışması Impulsivity in Idiopathic Parkinson Disease: Paired Case Control Study

INTRODUCTION: The aim of the current study was to estimate the frequency of Impulse Control Disorder (ICD) in patients with Idiopathic Parkinson’s Disease (IPD) and to investigate impulsivity in IPD patients. METHODS : 40 IPD patients (24 female, 16 male) treated with dopamine replacement therapy (DRT) and age and sex similar 40 healthy controls (HC) (23 female, 17 male) were included in this paired case-control study. Minnesota Impulsive Disorder Interview (MIDI) and the Turkish version of the Barratt Impulsiveness Scale (BIS-11) were applied to all participants. The patient and control groups were compared in terms of impulsivity and ICD. The effect of dopamine agonist (DA) usage on the presence of impulse control disorder was evaluated in the patient group. RESULTS : 7 patients with IPD (17.5%) and 1 healthy control (2.5%) reported at least one ICD in MIDI. Multiple ICDs were reported in 2 of 7 patients (28.57%) with IPD. group (p=0.002) and DA was found to be a significant risk for ICD. IPD patients had higher scores in total impulsivity, nonplanning, and cognitive impulsivity but interestingly lower scores in motor impulsivity as compared with controls. Except for motor impulsivity, the other domains of impulsivity including nonplanning and cognitive impulsivity were found to be increased in the presence of ICD in patients group. DISCUSSION AND CONCLUSION : Non-motor findings in IPD can be overlooked if they are not questioned. Increased impulsivity should be carefully followed in patients with IPD. It should be kept in mind that even IPD patients who had no ICD have increased tendencies for impulsivity, especially in non-planning and cognitive areas. In addition, the tests which only measures motor impulsivity may not be sufficient.
Comparison of incidence of dental caries in the mandibular (cid:2510)irst molar in teenagers versus adults

The mandibular (cid:977)irst molars are one of the (cid:977)irst permanent teeth to erupt; thus, it remains the longest in terms of exposure to cariogenic pathogens. Also, its anatomical location and structure make it a prime location for dental caries (DC) but hard to access for cleaning. Thus, we aim to compare its incidence in adults and teenagers because the identi(cid:977)ication of the most susceptible age for tooth decay is key in prevention and prophylaxis against the same. A retrospective cross-sectional study was conducted by reviewing and analysing the data of 86,000 patient records from June 2019 to April 2020. Patients with treated mandibular (cid:977)irst molars were selected from the age group of 13 and above. A Microsoft Excel 2016 data spreadsheet was used to collect data and was later exported to the Statistical Package for the Social Sciences for Windows (Version 20.0, SPSS). The number of males with DC in their mandibular (cid:977)irst molar (59%) was higher than that of the females (41%). The highest number of cases were reported to prevail in the ’Young Adults’ group, with 56.7%, followed by the ’Middle Adults’ with 26%. This shows that adults have a higher incidence of DC in their mandibular (cid:977)irst molars than teenagers. Also, there was a clear incidence of 46 having a higher incidence than caries in 36. (52.5% > 47.5%). There is an association between age and incidence of dental DC as proved by our Chi-Square Test, where we obtained a ’p’ value of p<0.05, making it statistically signi(cid:977)icant. Once lost, our teeth cannot be naturally replaced, making prevention imperative. Thus, identifying the age in which we are most prone to decay is a great leap forward. But since the study does present with limitations, further research needs to be done to con(cid:977)irm the same.
The entrepreneur as a relationship builder An exploratory study of the influence of the affective domain during the initiation of early customer relationships in an entrepreneurial B2B setting

Entrepreneurship as method literature aspires to guide the entrepreneur towards successful venture development. While providing the entrepreneur with useful guidelines for venture development, little emphasis has been put on how the entrepreneur get in contact with their early customers. Furthermore, in contrast to other streams of literature, entrepreneurship as method literature makes no distinction between business to business and business to consumer markets. To study how relationships are created becomes especially crucial in a business to business setting where customer contacts are limited and highly valuable. Moreover, the entrepreneurship as method literature has depicted the entrepreneur as an actor making rational choices. Hence, this thesis focus on business to business entrepreneurs and assumes that a potential customer's decision to enter a business relationship with an aspiring entrepreneur is based in the rational domain, as well as the affective domain. It is specifically the influence of the affective domain that this thesis has examined and explored. This thesis has used an abductive research logic in order to develop an understanding of customer engagement in the entrepreneurship as method discourse. A concurrent development of the theoretical and the empirical led to the development of four propositions in relation to initial customer engagement. These are compared to the collected empirical material, which consists of seven interviews with entrepreneurs operating in a business to business environment. The findings highlight the interpersonal relationship between the business to business entrepreneur and its early customers as an important facilitator for the initiation of a relationship. Specifically, the findings showcase that entrepreneurial decision making is also based in the affective domain during initial customer engagement. This is noteworthy as entrepreneurship as method literature have focused on the rational as a basis for decision making. The conclusions of this thesis highlight the interpersonal relationship between an entrepreneur and early customers as important. Hence, the entrepreneur cannot only be viewed as a product or service developer, but must also be viewed as a relationship developer.
The performativity of a management accounting and control system: Exploring the dynamic relational consequences of a design

This paper contributes to the knowledge of the performativity of accounting by exploring the unexpected consequences of a management accounting and control system (MAC) as designed in a large public organization. In an organization in the Dutch sector of Nursing Homes, Homes for the Elderly and Homecare MAC turns from a system into an actor-network. Rather than being a stable answer machine in the context of decision making or a ready-made tool for performance management by which distant (top) managers and controllers aim to measure and manage performance from time-space distances, MAC is grounded in relations and performatively develops. As such, it becomes multiple. The study shows how the performativity of MAC goes beyond its functionality. Though originating from MAC ’ s functional design, MAC ’ s performativity is not simply about the degree to which it realizes the intentions of its designers, but is about its dynamic relational consequences. Controllers should mediate in the dynamics of MAC so that processes of learning are enhanced and the quality and e ﬃ ciency of the care practices develop.
Transgender labour market outcomes: Evidence from the US

Alternative labour market outcomes for men and women have been studied extensively in past literature. However, existing studies fail to directly compare labour market differences between transgender and non-transgender people. We utilise data from the 2015 Behavioral Risk Factor Surveillance System in the US to examine employment and wage differentials between transgender persons and non-transgender people using the Fairlie (2005) decomposition method. Our findings suggest that transgender people are less likely than nontransgender people to be employed, and are more likely than non-transgender people to receive lower wages. While some of the difference in employment and wage gaps is explained by sociodemographic characteristics, part of the gap remains unexplained. Approximately 64 per cent of the employment differential and 43 per cent of the wage differential is unexplained and may be due to discrimination. Therefore, our findings highlight the importance of appropriate anti-discrimination policy.
PROCEEDINGS OF THE AUSTRALIAN SOCIETY FOR REPRODUCTIVE BIOLOGY

Studies of Australian marsupials have shown that glucose rather than fructose is the major sugar of the prostate gland (Rodger & White, 1974a) and that glucose, inositol and N-acetylglucosamine occur in ejaculated seminal plasma (Rodger & White, 1974b). The present paper gives data on the glandular origin of the seminal N-acetylglucosamine and extends the study of the bio¬ chemistry of the prostate to additional marsupial species. The results of analyses of the N-acetylhexosamine levels in the semen of some eutherian species are also