Miracle-dz/UniFAR-FTUs huggingface dataset:
Reduction of Dipeptidyl Peptidase 4 Activity in Patients with Type 2 Diabetes Mellitus Who Consumed Fruits Before Meals

Objectives Some patients with type 2 diabetes mellitus (T2DM) have high expression of dipeptidyl peptidase 4 (DPP4) enzymes that breaks down glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide 1 (GLP1) hormones. In the process of eating carbohydrates, K and L cells in the human small intestine produce GIP and GLP1 respectively that stimulate pancreatic β cells to release insulin. Recent evidence has revealed that fruit consumption before meals reduces fasting blood glucose level in patients with T2DM. Therefore, this study aimed to investigate the effect of fruit consumption before meals on DPP4 activity among patients with T2DM. MethodsA randomized control trial study with pre-posttest control group design was performed in 18 T2DM patients. They were randomly divided into 2 groups: 10 in the control (C) group eating a standardized diet and the other in the treatment (T) group eating fruit before consumption of standardized diet. Fasting and postprandial serum DPP4 activities in 30 min were measured using an H-Gly-Pro-pNA substrate in the 1st and 7th day’s intervention. Paired Sample t-Tests and Wilcoxon were used to analyze mean DPP4 activity in both groups with p value < 0.05. Results In 1st day intervention, mean fasting DPP4 activity in the C group (189.42+116.27 nmol/ min/ mg protein) was higher than mean fasting DPP4 activity in the T group (121.75±74.86 nmol/ min/ mg protein). Reduced postprandial DPP4 activity was found in the T group (116,86+61.44) and increased in the C group (287,15+146.72). After 7 days intervention, reduction of fasting and postprandial DPP4 activities was observed in the C and T groups respectively. Meanwhile, mean fasting DPP4 activity in the T group remained unchanged but followed by increasing postprandial DPP4activity. Conclusions Fruit consumption before meals reduces fasting and increases postprandial DPP4 activities in patients with T2DM.
The influence of perceptions of sleep on wellbeing in youth athletes Running Influence of sleep on wellbeing in youth athletes

21 To date, the majority of research considering wellbeing questionnaires has only considered the 22 training stress imposed on the athlete, without evaluating the questionnaire's relationship with a 23 measure of recovery (e.g. sleep). This study aimed to assess the influence of sleep duration (S duration ), 24 sleep quality (S quality ) and sleep index (S index ; S duration x S quality ) on wellbeing in youth athletes, whilst 25 accounting for the known training stressors of training load and exposure to match play. Forty-eight 26 youth athletes (age 17.3 ± 0.5 years) completed a daily questionnaire including wellbeing (DWB no- 27 sleep ; fatigue, muscle soreness, stress and mood) measures, Perceived Recovery Scale (PRS), the 28 previous day's training loads, S duration and S quality every day for 13 weeks. Linear mixed models 29 assessed the impact of S duration , S quality and S index on DWB no-sleep , its individual subscales, and PRS. 30 S duration had a small effect on DWB no-sleep ( d =0.31; ±0.09), fatigue ( d =0.42; ±0.11) and PRS ( d =0.25; 31 ±0.09). S quality had a small effect on DWB no-sleep ( d =0.47; ±0.08), fatigue ( d =0.53; ±0.11), stress 32 ( d =0.35; ±0.07), mood ( d =0.41; ±0.09) and PRS ( d =0.37; ±0.08). S index had a small effect on DWB no- 33 sleep ( d =0.44; ±0.08), fatigue ( d =0.55; ±0.11), stress ( d =0.29; ±0.07), mood ( d =0.37; ±0.09) and PRS 34 ( d =0.36; ±0.09). The results indicate that an athlete's perceptions of sleep are associated with 35 deviations in wellbeing measures and should be used as an input to the monitoring process rather than 36 as part of the outcome wellbeing score. The sleep index is suggested as a potential input as it provides 37 information on both the duration and quality of the sleep experienced. of self-reported quality sleep while training stressors of training load DWB four DWB, sleep quality subscales muscle soreness, stress and mood) and PRS as wellbeing self-reported sleep match
Proximate and Sensory Evaluation of Fermented Seasonings from Soybean and Fluted Pumpkin Seeds

Specialty condiment (ogiri) was produced from seeds of soybean (Glycine max) and fluted pumpkin (Telfairia occidentalis) by spontaneous moist solid substrate fermentation of their preprocessed mash. The two samples coded FSBM and FFPM respectively were evaluated for nutritional quality. Effects of fermentation on proximate values of the seeds were also analyzed. The two samples were further subjected to sensory analysis using commercial brand made from castor bean (Ricinus communis) seeds coded FCBM as a control. Results show that FFPM was significantly (p < 0.05) higher in ash, crude fiber and protein, but significantly lower in moisture and fat than the FSBM. There was no significant (p > 0.05) difference in carbohydrate content of the two samples. The FFPM recorded significant (p < 0.05) increase in crude fiber, fat and protein, and significant (p < 0.05) decrease in moisture, ash and carbohydrate compared to the values in the fluted pumpkin seeds. The FSBM recorded significant (p < 0.05) rise in fat and protein, but significant drop in moisture, ash, crude fiber and carbohydrate compared to the values in soybean seeds. Sensory results show that FFPM was significantly (p < 0.05) higher than FSBM in flavor and Original Research Article Ifediba and Egbuna; AFSJ, 14(2): 27-35, 2020; Article no.AFSJ. 54044 28 marginally (p > 0.05) different in color, texture, taste and general acceptability. Baring the marginal (p < 0.05) superiority in taste, the FCBM was significantly (p<0.05) lower in every other attributes considered. It follows that good quality fermented condiments can be obtained from cheaper and underutilized oil seeds.
A New Formulation of Methylphenidate: Phase 3 Study of the Efficacy and Tolerability of an Extended-Release Orally Disintegrating Tablet in Children 6-12 Years of Age With ADHD

This study was funded by Neos Therapeutics, Inc (Grand Prairie, TX). Statistical expertise was provided by John Perrett, MSc. Editorial support was provided by Liqing Xiao, PhD, of AlphaBioCom, LLC (King of Prussia, PA). ■ In this phase 3 classroom study, the postdose SKAMP-Combined scores averaged over the classroom testing day were significantly lower in the MPH XR-ODT group than in the placebo group
MODERATING EFFECTS OF TIME SPENT PER ONLINE SHOPPING TRANSACTION ON THE RELATIONSHIP BETWEEN ETHICAL SALES BEHAVIOR BRAND TRUST AND POSITIVE WORD OF MOUTH

Social media has turned out to be an instrument of the cutting-edge way of life, as well as an essential channel for business. While numerous studies have demonstrated how customers assess their positive word-of-mouth communication with ethical sales behavior and customer’s trust in brand, little is known as a moderating factor effect a positive wordof-mouth communication of online shoppers. This study aims to demonstrate the causal effects of ethical sales behavior, and customer’s trust in brand on positive word-of-mouth communication and investigate the moderating effects of average shopping time on the relationship of perceived ethical sales behavior, customer trust in brand, and positive word of mouth in online shopping context. The data was collected from 332 online buyers and analyzed by Structural Equation Modeling analysis (SEM). The research results and findings might contribute to online entrepreneurs in all size of business for establishing the ethical sales behavior to foster the sustainable relationships with their customers.
Intrathecal nalbuphine versus intrathecal fentanyl as adjuvant to 0.5% hyperbaric bupivacaine for orthopedic surgery of lower limbs under subarachnoid block: A comparative evaluation

Background: Subarachnoid block (SAB) possesses many benefits with a drawback of short duration of anesthetic action. Intrathecal opioids have been used to enhance the clinical efficiency and duration of action of local anesthetic drugs. The present study was aimed to compare the clinical efficiency of intrathecal fentanyl with nalbuphine as adjuvant to 0.5% hyperbaric bupivacaine for orthopedic surgery of lower limbs. Patients and Methods: Sixty-eight adult patients of American Society of Anesthesiologist physical status I and II of both gender aged 25-65 years were randomized into two groups of 34 each to receive either fentanyl 25 μg (Group I) or nalbuphine 2 mg (Group II) with 3.5 mL 0.5% hyperbaric bupivacaine, making intrathecal drug volume to 4 mL in each group. Sensory and motor block characteristics and time to first rescue analgesic (intravenous tramadol 100 mg) were recorded as the primary end points. Drug-related side effects of pruritus, nausea/vomiting, and respiratory depression were recorded as the secondary outcomes. Results: Both groups were comparable regarding the onset and cephalic extension of block. The time to two dermatome regressions and time for complete motor recovery were significantly prolonged in patients of Group II with statistical significant difference (P < 0.05). Duration of analgesia was also extended in patients of Group II (378.0 ± 35.72 min) as compared to Group I (234.0 ± 24.10 min) with highly significant difference (P < 0.001). No drug-related side effects were observed in either group. Conclusion: Intrathecal nalbuphine 2 mg as adjuvant to 0.5% bupivacaine was clinically more efficient than fentanyl for enhancing the postoperative analgesia.
Interleukin 1β-mediated HOXC10 Overexpression Promotes Hepatocellular Carcinoma Metastasis by Upregulating PDPK1 and VASP

Rationale: Metastasis and recurrence are the primary reasons for the high mortality rate of human hepatocellular carcinoma (HCC) patients. However, the exact mechanism underlying HCC metastasis remains unclear. The Homeobox (HOX) family proteins, which are a highly conserved transcription factor superfamily, play important roles in cancer metastasis. Here, we report a novel role of HOXC10, one of the most upregulated HOX genes in human HCC tissues, in promoting HCC metastasis. Methods: The expression of HOXC10 and its functional targets was detected by immunohistochemistry in two independent human HCC cohorts. Luciferase reporter and chromatin immunoprecipitation assays were used to measure the transcriptional regulation of target genes by HOXC10. The effect of HOXC10-mediated invasion and metastasis were analyzed by Transwell assays and by an orthotopic metastasis model. Results: Elevated expression of HOXC10 was positively correlated with the loss of tumor encapsulation and with higher tumor-nodule-metastasis (TNM) stage and poor prognosis in human HCC. Overexpression of HOXC10 promoted HCC metastasis by upregulating metastasis-related genes, including 3-phosphoinositide-dependent protein kinase 1 (PDPK1) and vasodilator-stimulated phosphoprotein (VASP). Knockdown of PDPK1 and VASP inhibited HOXC10-enhanced HCC metastasis, whereas upregulation of PDPK1 and VASP rescued the decreased metastasis induced by HOXC10 knockdown. Interleukin-1β (IL-1β), which is the ligand of IL-1R1, upregulated HOXC10 expression through the c-Jun NH2-terminal kinase (JNK)/c-Jun pathway. HOXC10 knockdown significantly reduced IL-1β-mediated HCC metastasis. Furthermore, Anakinra, a specific antagonist of IL-1R1, inhibited IL-1β-induced HOXC10 upregulation and HCC metastasis. In human HCC tissues, HOXC10 expression was positively correlated with PDPK1, VASP and IL-1R1 expression, and patients with positive coexpression of HOXC10/PDPK1, HOXC10/VASP or IL-1R1/HOXC10 exhibited the poorest prognosis. Conclusions: Upregulated HOXC10 induced by IL-1β promotes HCC metastasis by transactivating PDPK1 and VASP expression. Thus, our study implicates HOXC10 as a prognostic biomarker, and targeting this pathway may be a promising therapeutic option for the clinical prevention of HCC metastasis.
Host Mesh Fitting of a Generic Musculoskeletal Model of the Lower Limbs to Subject-Specific Body Surface Data: A Validation Study

The Filter Inlet for Gases and AEROsols (FIGAERO) is an inlet specifically designed to be coupled with the Aerodyne High-Resolution Time-of-Flight Chemical Ionization Mass Spectrometer (HR-ToF-CIMS). The FIGAERO-HR-ToF-CIMS provides simultaneous molecular information relating to both the gasand particle-phase samples and has been used to extract vapour pressures (VPs) of the compounds desorbing from the filter whilst giving quantitative concentrations in the particle phase. However, such extraction of vapour pressures of the measured particle-phase components requires use of appropriate, well-defined, reference compounds. Vapour pressures for the homologous series of polyethylene glycols (PEG) ((H−(O−CH2−CH2)n−OH) for n= 3 to n= 8), covering a range of vapour pressures (VP) (10−1 to 10−7 Pa) that are atmospherically relevant, have been shown to be reproduced well by a range of different techniques, including Knudsen Effusion Mass Spectrometry (KEMS). This is the first homologous series of compounds for which a number of vapour pressure measurement techniques have been found to be in agreement, indicating the utility as a calibration standard, providing an ideal set of benchmark compounds for accurate characterization of the FIGAERO for extracting vapour pressure of measured compounds in chambers and the real atmosphere. To demonstrate this, single-component and mixture vapour pressure measurements are made using two FIGAERO-HR-ToF-CIMS instruments based on a new calibration determined from the PEG series. VP values extracted from both instruments agree well with those measured by KEMS and reported values from literature, validating this approach for extracting VP data from the FIGAERO. This method is then applied to chamber measurements, and the vapour pressures of known products are estimated.
Estimation of Anti-thyroglobulin and Anti-Thyroid peroxidase among thalassemia major patients

Introduction: Hypothyroidism the most common thyroid dysfunction appears in thalassemia. The current study aimed to estimate thyroid function through detecting the presence of anti-thyroid peroxidase, anti-Thyroglobulin, T3, T4 and TSH.Material and Subject: Cross sectional study carried out on 100 patients with thalassemia major (52 male and 48 female) with average age (13.9 ± 10.0) years. Tests of thyroid function (TSH, T4, and T3) were estimate via using an automated quantitative COBAS e411. While, Anti-thyroglobulin and Anti-Thyroid peroxidase were estimated by using ELISA technique. Results: Euthyroid was enrolled in 67 (67%) of 100 patients who suffer from thalassemia major. While, 31 (31%) have subclinical of hypothyroidism and only 2 patients (2%) patients were overt hypothyroidism. Among these 100 patients, Anti-thyroid peroxidase was detected in 26 patients (26%) and anti-thyroglobulin test was positive in 18 patients (18%). Conclusion: Thyroid dysfunction is frequent in thalassemia patients. The main thyroid dysfunction hypothyroidism and autoimmune disease also frequents in thalassemia patients.
Classification of cucumber germplasm based on agronomic traits under natural climatic conditions

Vegetables have been known from ancient times as fresh and edible parts of herbaceous plants. They play vital role in maintenance of health and help in prevention from a number of diseases. Vegetables have been main source of carbohydrates, vitamin and mineral. Vegetables can be available in different edible forms such as roots, stems, leaves, fruits and seeds. Each edible group have its own contribution. Cucumber is cultivated all around the world and held an important position in cucurbitaceous crops. Seeds of cucumber have cooling, tonic, diuretic and anthelmintic effect. There were total 12 different varieties and central devoutness of the study was to compare all these varieties and to know about the best variety among all. After comparing means from data it was conducted that in terms of days of germination, the fastest germination rate was observed that three varieties C-571, Cucumber Vega and Desi cucumber respectively followed by C-3429 and remaining varieties showed almost same trend, but the variety which took highest number of days to germinate was C-574. All the varieties showed almost similar trend in length of stem and days of flowering. C-3479 possessed highest number of fruits and Sialkot local had lowest number of fruits. Three varieties C-571, 574 and C-3429 exhibited highest yield. The biggest size of leaf was variety WANDRI-700. This study revealed the germination rates and the fastest germination rate was observed that three varieties C-571, Cucumber Vega and Desi cucumber. In terms of Numb of leaves C-3479, C-571 and Sialkot local beard highest number of leaves.
Re-Innovation from Failure, Institutional Environmental Differences, and Firm Performance: Evidence from China

Due to an anti-failure bias, theoretical and practical studies have not focused much on the problem of innovation failure. The literature does not include studies on how the effect of re-innovation input on firm performance can still be explained by existing theories, especially in the case of previous innovation failures. To explore the intrinsic relationship between the re-innovation from failure and firm performance, as well as the influencing mechanism of the institutional environment differences on a firm’s re-innovation activities, using the data of the Listed Companies in China’s pharmaceutical manufacturing industry from 2008 to 2014 and a multiple regression model, the relationships between the re-innovation from failure, institutional environment differences, and firm performance were analyzed from 3 aspects: government intervention, financial development, and legal environment. The results show that the re-innovation input from failure has a significant positive impact on firm performance. The level of government intervention and the level of financial development play significant negative and positive moderating roles in the relationship between the re-innovation input and firm performance, respectively, and the above-mentioned effects are more prominent in eastern China. Moreover, with the improvement of the marketization of the financial industry, the beneficial effect of the re-innovation input from failure on firm performance in state-owned firms will be further strengthened. However, the moderating effect of the legal environment is not obvious.
Occurrence of Gill Monogenean Parasites in Redbelly tilapia, Tilapia zillii (Teleostei: Cichlidae) from Lobo River, Côte d’Ivoire

1 ABSTRACT A study was made on gill monogenean infestation of 231 Tilapia zillii (Redbelly tilapia) collected from Lobo River during August 2004 to July 2005. After recording biometric characteristics, common necropsy and parasitology methods were used. Three species belonging to genus Cichlidogyrus (C. digitatus, C. aegypticus and C. vexus) were recorded. An aggregated dispersion for all monogenean species was observed. There was a positive and significant correlation between the intensity of infection and the relative condition factor. The infestation exhibited seasonal fluctuation; the maximum intensities of parasite infection were recorded in the rainy seasons and the minimum in the dry seasons. The higher value of Shannon based evenness suggests that community structures show consistent distribution of all species during the seasons of the year. As to host size-related incidence, the differences in the number of the three species among the four-host size classes were significant (p < 0.05). No significant differences were found in the infrapopulations of the three parasite species between host sexes and in the distribution of these parasites among the left and right-hand gill sets (p ˃ 0.05). In contrast, parasite species mostly concentrated in the middle arches (p < 0.05). This information is information will allow further researches on protocols for monitoring parasitic infection in intensive fish farming.
Application of widely used fungicides does not necessarily affect grain yield, and incidence of Fusarium spp. and mycotoxins DON, HT-2 and T-2 in spring barley in northern climates

Fungicides are widely used to reduce Fusarium infections and grain contamination by mycotoxins and increase the yield in cereals, but the efficacy of fungicide treatments in varying climates has not been systematically explored. Field experiments with Estonian spring barley (Hordeum vulgare L.) cv. ‘Maali’ were carried out in three successive years 2012–2014 with strongly varying weather conditions to study the effects of three fungicides, Folicur (active ingredient tebuconazole), Falcon Forte (prothioconazole, tebuconazole, spiroxamine) and Archer Top (fenpropidin, propiconazole), on the yield, incidence of Fusarium spp. and on the contamination of grain with mycotoxins DON, HT-2 and T-2. The fungicides were sprayed once a year at spring barley flowering time. The weather conditions during the three years of study were extremely different. The content of cycotoxin DON, HT2 and T2 was low. The spraying with fungicides had not a clear effect on the barley yield and 1 000 kernel weight, and the study year was primarily the main factor that affected barley yield (p<0.05) and 1 000 kernel weight (p<0.05). The impact of year together with fungicide treatment had a significant effect on the incidence of Fusarium spp. (p<0.05) and on the incidence of mycotoxin DON in barley kernels (p<0.001), but did not have a clear effect on the incidence of mycotoxins HT2 and T2.
ToXIC Toy or ToXIC WasTe: old PoPs In neW ProduCTs

This study brings forward evidence about recycling of plastic parts of electronic waste contaminated by POPs-PBDEs as well as by alternatives to PBDEs also raising concern into magic cube toys. The results raise concerns about Low POPs Content Level (LPCL) of PBDEs and E-waste management, including recycling materials containing flame retardants that result in further human and environmental exposure to substances listed in the Stockholm Convention for global elimination, particularly for E-waste workshop operators, recyclers and children. Magic cubes made of black hard plastic purchased in Armenia, Czech Republic, Hungary, Serbia, and China, and the original Rubick ́s cubes® purchased in Hungary and Czech Republic, were screened for bromine using a handheld XRF analyzer and analyzed in the laboratory for polybromodiphenyl ethers (PBDEs) and new, alternative brominated flame retardants (nBFRs). Bromine was not detected at significant levels in samples from Armenia and Czech Republic. Laboratory analysis of 7 samples from Belarus, Hungary, Serbia and China found that six samples of magic cubes contained components of a commercial octaBDE mixture (hexabromodiphenyl and heptabromodiphenyl ethers), which is listed in the Stockholm Convention for global elimination, in concentrations ranging from 3 to 57 ppm and with a median value of 13 ppm. Content of substances resembling commercial octaBDE exceeded the provisional Low POPs Content Level of 50 ppm set for PCBs 1 , in one of the samples. Four samples of magic cubes from Serbia and China exceeded the EU Low POPs Content limit for heptabromodiphenyl ether. Concentrations of the flame retardant decaBDE, which has been proposed for addition to the Convention, ranged from 36 to 153 ppm with the median value of 42 ppm. Only the original Rubick ́s cube® from Hungary did not contain significant levels of the PBDEs or nBFRs, indicating that only this sample was not very likely made of recycled E-waste plastics.