Miracle-dz/UniFAR-FTUs huggingface dataset:
Small domain estimation of business statistics by using multivariate skew normal models

Small domain business statistics are becoming important for better planning business policies. We focus on the estimation of the averages of value added and labour cost in small domains. To take into account the positive skewness in the distribution of outcomes and the correlation between them, we propose a bivariate skew normal small area model. Estimates are obtained from real survey data. The performance of the estimator proposed is evaluated on the basis of both survey data and a synthetic firm population. Results show that the model proposed increases the estimates’ reliability and that the estimates obtained make it possible to perform detailed regional economic studies.
Sharper Bounds for Uniformly Stable Algorithms with Stationary Mixing Process

Generalization analysis of learning algorithms often builds on a critical assumption that training examples are independently and identically distributed, which is often violated in practical problems such as time series prediction. In this paper, we use algorithmic stability to study the generalization performance of learning algorithms with ψ -mixing data, where the dependency between observations weakens over time. We show uniformly stable algorithms guarantee high-probability generalization bounds of the order O (1 / √ n ) (within a logarithmic factor), where n is the sample size. We apply our general result to speciﬁc algorithms including regularization schemes, stochastic gradient descent and localized iterative regularization, and develop excess population risk bounds for learning with ψ -mixing data. Our analysis builds on a novel moment bound for weakly-dependent random variables on a ϕ -mixing sequence and a novel error decomposition of generalization error
Preliminary Test of Typhoon Forecast with a Moving Multi-Nested Grid (MNG)

Based on the grid-nesting method proposed by the present author (1974), a Movable, multi-Nested Grid scheme (hereafter, MNG) is formulated to apply to a three-level primitive equation model in the a-coordinate system. The outermost grid size is 381 km at 6*N and the mesh ratio for each inner subdomain is one half. The interface condition between different nets is the so called "two-way" interaction. The Euler-backward scheme is adopted for the time integration. The heating due to cumulus ensemble is represented in the same way as the circular symmetric heating function proposed by Harrison (1973). Several preliminary tests have been carried out to examine the computational characteristics of the scheme and to see how the present MNG method works with real data (T7609, T7617, T7709 and T7711) produced by the JMA operational objective analysis system. The grid values of the finer grid net are calculated by a cubic interpolation formula step by step, and analyzed values on the innermost grid are modified as a results of the superposition of the symmetric model typhoon which is specified by the observed diameter of typhoon, the central surface pressure, the maximum surface wind and the temperature anomaly. The scheme has been tested with the 3and 4-step MNG's. The predicted trajectories of the typhoon with these MNG's show the trend of improvement compared with those obtained by the JMA operational numerical weather prediction models. In addition, the three-dimensional structure simulated by the proposed 4-step MNG scheme is also discussed.
Influence of stratification on the groups of conformal transformations of pseudo-Riemannian orbifolds

We study the groups of conformal transformations of n-dimensional pseudoRiemannian orbifolds (N , g) as n > 3. We extend the Alekseevskii method for studying conformal transformation groups of Riemannian manifolds to pseudo-Riemannian orbifolds. We show that a conformal pseudo-Riemannian geometry is induced on each stratum of such orbifold. Due to this, for k ∈ {0, 1}∪ {3, . , n− 1}, we obtain exact estimates for the dimensions of the conformal transformation groups of n-dimensional pseudo-Riemannian orbifolds admitting k-dimensional stratum with essential groups of conformal transforms. A key fact in obtaining these estimates is that each connected transformation group of an orbifold preserves every connected component of each its stratum. The influence of stratification of n-dimensional pseudo-Riemann orbifold to the similarity transformation group of this orbifold is also studied for n > 2. We prove that the obtained estimates for the dimension of the complete essential groups of conformal transformations and the similarity transformation groups of n-dimensional pseudo-Riemann orbifolds are sharp; this is done by adducing corresponding examples of locally flat pseudo-Riemannian orbifolds.
Socioeconomic Inequalities in Alcohol and Tobacco Consumption: A National Ecological Study in Mexican Adolescents

Alcohol and cigarettes are the psychoactive substances that adolescents use most frequently. When both addictions are combined, they carry the worst burden of disease globally. The objective of this study was to identify whether socioeconomic factors correlate with alcohol and tobacco consumption in Mexican adolescents aged 10 years or more and to establish the relationship in the consumption between the two substances. This ecological study utilized data describing alcohol and tobacco consumption among adolescents aged 10–16 years (n = 48,837 ≈ N = 11,621,100). Having ever consumed any alcohol-containing beverage constituted alcohol consumption. Smoking a cigarette within 30 days constituted cigarette consumption. For both variables, the state-level percentages reported in the survey were used. Diverse socioeconomic variables were collected from official sources. Data on the prevalence of tobacco use and alcohol consumption were entered into an Excel database estimated for each of the states of the Mexican Republic, as well as the socioeconomic variables. We performed the analysis using Stata 14. Consumption prevalence was 15.0% for alcohol and 4.2% for tobacco. Alcohol consumption was not correlated with any studied socioeconomic variable (p > 0.05). The prevalence of tobacco consumption among elementary school students correlated (p < 0.05) with the portion of the population living in private dwellings without sewage, drainage, or sanitation (r = 0.3853). The prevalence of tobacco consumption among middle-school adolescents correlated with the portion of the employed population that earned up to two minimum wages (r = 0.3960), the percentage in poverty by income 2008 (r = 0.4754) and 2010 (r = 0.4531), and the percentage in extreme poverty by income 2008 (r = 0.4612) and 2010 (r = 0.4291). Positive correlations were found between tobacco consumption and alcohol consumption among both elementary (r = 0.5762, p=0.0006) and middle-school children (r = 0.7016, p=0.0000). These results suggest that certain socioeconomic factors correlate with tobacco consumption but not alcohol consumption. A correlation between alcohol consumption and tobacco consumption was observed. The results can be used for developing interventions in adolescents.
Searching for the Best Treatment for Ramp Lesions: A Systematic Review and Network Meta-Analysis

Ramp lesions are a common occurrence in patients with anterior cruciate ligament (ACL) tears. These lesions can be difficult to diagnose due to their concealed nature, and their treatment is crucial due to the stabilizing function of the medial meniscocapsular region. The optimal treatment option for ramp lesions varies depending on the size and stability of the lesion. The purpose of this study was to evaluate the best treatment option for ramp lesions based on the stability of the lesion, including no treatment, biological treatment, and arthroscopic repair. We hypothesize that stable lesions have a favorable prognosis with techniques that do not require the use of meniscal sutures. In contrast, unstable lesions require appropriate fixation, either through an anterior or posteromedial portal. This study is a systematic review and meta-analysis with a level of evidence IV. The study used Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines for a systematic review of clinical studies reporting outcomes of ramp lesion treatment. The PubMed/MEDLINE database was searched using Mesh and non-Mesh terms related to ramp lesions, medial meniscus ramp lesions, and meniscocapsular injuries. The inclusion criteria encompassed clinical studies in English or Spanish that reported the treatment of ramp meniscal lesions, with a follow-up of at least six months and inclusion of functional results, clinical stability tests, radiological evaluation, or arthroscopic second look. The analysis included 13 studies with 1614 patients. Five studies distinguished between stable and unstable ramp lesions using different criteria (displacement or size) for assessment. Of the stable lesions, 90 cases received no treatment, 64 cases were treated biologically (debridement, edge-curettage, or trephination), and 728 lesions were repaired. There were 221 repaired unstable lesions. All different methods of repair were registered. In stable lesions, three studies were included in a network meta-analysis. The best-estimated treatment for stable lesions was biological (SUCRA 0.9), followed by repair (SUCRA 0.6), and no treatment (SUCRA 0). In unstable lesions, seven studies using International Knee Documentation Committee Subjective Knee Form (IKDC) and 10 studies using Lysholm for functional outcomes showed significant improvement from preoperative to postoperative scores after repair, with no differences between repairing methods. We recommend simplifying the classification of ramp lesions as stable or unstable to determine treatment. Biological treatment is preferred for stable lesions rather than leaving them in situ. Unstable lesions, on the other hand, require repair, which has been associated with excellent functional outcomes and healing rates.
Economic value in the Brain: A meta-analysis of willingness-to-pay using the Becker-DeGroot-Marschak auction

Forming and comparing subjective values (SVs) of choice options is a critical stage of decision-making. Previous studies have highlighted a complex network of brain regions involved in this process by utilising a diverse range of tasks and stimuli, varying in economic, hedonic and sensory qualities. However, the heterogeneity of tasks and sensory modalities may systematically confound the set of regions mediating the SVs of goods. To identify and delineate the core brain valuation system involved in processing SV, we utilised the Becker-DeGroot-Marschak (BDM) auction, an incentivised demand-revealing mechanism which quantifies SV through the economic metric of willingness-to-pay (WTP). A coordinate-based activation likelihood estimation meta-analysis analysed twenty-four fMRI studies employing a BDM task (731 participants; 190 foci). Using an additional contrast analysis, we also investigated whether this encoding of SV would be invariant to the concurrency of auction task and fMRI recordings. A fail-safe number analysis was conducted to explore potential publication bias. WTP positively correlated with fMRI-BOLD activations in the left ventromedial prefrontal cortex with a sub-cluster extending into anterior cingulate cortex, bilateral ventral striatum, right dorsolateral prefrontal cortex, right inferior frontal gyrus, and right anterior insula. Contrast analysis identified preferential engagement of the mentalizing-related structures in response to concurrent scanning. Together, our findings offer succinct empirical support for the core structures participating in the formation of SV, separate from the hedonic aspects of reward and evaluated in terms of WTP using BDM, and show the selective involvement of inhibition-related brain structures during active valuation.
Adaptive optimal fault-tolerant control scheme for a class of strict-feedback nonlinear systems

An active optimal fault-tolerant control (FTC) scheme for a class of nonlinear systems in strict-feedback form in the presence of partial loss of actuator effectiveness faults is proposed, using backstepping design technique and adaptive dynamic programming (ADP) algorithm to compensate the effects of failure. The proposed FTC scheme consists of feedforward controller that achieve the objective of fault-tolerant and feedback optimal controller, which can guarantee the performance index function is minimized. Since fault estimation and control law parameters are updated online, the control system has an adaptive failure compensation capability so as to reconfigure the control law in real time in response to failure indications. Based on Lyapunov stability theory, the whole closed-loop system is guaranteed to be ultimately uniformly bounded. Finally, the effectiveness of the proposed method is demonstrated by simulation.
Categorical consistency facilitates implicit learning of color-number associations

In making sense of the environment, we implicitly learn to associate stimulus attributes that frequently occur together. Is such learning favored for categories over individual items? Here, we introduce a novel paradigm for directly comparing category- to item-level learning. In a category-level experiment, even numbers (2,4,6,8) had a high-probability of appearing in blue, and odd numbers (3,5,7,9) in yellow. Associative learning was measured by the relative performance on trials with low-probability (p = .09) to high-probability (p = .91) number colors. There was strong evidence for associative learning: low-probability performance was impaired (40ms RT increase and 8.3% accuracy decrease relative to high-probability). This was not the case in an item-level experiment with a different group of participants, in which high-probability colors were non-categorically assigned (blue: 2,3,6,7; yellow: 4,5,8,9; 9ms RT increase and 1.5% accuracy increase). The categorical advantage was upheld in an explicit color association report (83% accuracy vs. 43% at the item-level). These results support a conceptual view of perception and suggest empirical bases of categorical, not item-level, color labeling of learning materials.
Recurrent Catatonia and Demyelinating Disorders

Catatonia, a neuropsychiatric syndrome characterized by psychomotor and behavioral symptoms, can be associated with various underlying conditions, including demyelinating diseases such as multiple sclerosis. This paper presents a case study of a 47-year-old female with recurrent catatonic relapses and an underlying demyelinating disease. The patient exhibited symptoms of confusion, decreased oral intake, and difficulty with movement and speech. Neurological examinations, brain imaging, and laboratory tests were conducted to evaluate the etiology and guide treatment. The patient showed improvement with lorazepam and electroconvulsive therapy (ECT). However, relapses occurred after the abrupt withdrawal of medication. The case study highlights the potential connection between demyelinating diseases and catatonia and emphasizes the importance of considering demyelinating diseases in the workup, treatment, and relapse prevention of catatonia. Further research is needed to explore the mechanisms underlying the relationship between demyelination and catatonia and to investigate how different etiologies may impact the recurrence rates of catatonic episodes.
TP53-Mutated Myelodysplasia and Acute Myeloid Leukemia

TP53-mutated myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) form a distinct and heterogeneous group of myeloid malignancies associated with poor outcomes. Studies carried out in the last years have in part elucidated the complex role played by TP53 mutations in the pathogenesis of these myeloid disorders and in the mechanisms of drug resistance. A consistent number of studies has shown that some molecular parameters, such as the presence of a single or multiple TP53 mutations, the presence of concomitant TP53 deletions, the association with co-occurring mutations, the clonal size of TP53 mutations, the involvement of a single (monoallelic) or of both TP53 alleles (biallelic) and the cytogenetic architecture of concomitant chromosome abnormalities are major determinants of outcomes of patients. The limited response of these patients to standard treatments, including induction chemotherapy, hypomethylating agents and venetoclax-based therapies and the discovery of an immune dysregulation have induced a shift to new emerging therapies, some of which being associated with promising efficacy. The main aim of these novel immune and nonimmune strategies consists in improving survival and in increasing the number of TP53-mutated MDS/AML patients in remission amenable to allogeneic stem cell transplantation.
Multimorbidity and Quality of Life: The Mediating Role of ADL, IADL, Loneliness, and Depressive Symptoms

Abstract Background and Objectives The ubiquity of multimorbidity makes it crucial to examine the intermediary factors linking it with quality of life (QoL). The objective was to examine to what extent the association between multimorbidity and QoL was mediated by functional and emotional/mental health and how these mediation pathways differed by sociodemographic factors (age, gender, education, and financial strain). Research Design and Methods Data from Waves 4 to 8 of 36,908 individuals from the Survey of Health, Aging, and Retirement in Europe (SHARE) were included. Multimorbidity (exposure) was defined as having 2 or more chronic conditions. Mediators included limitations with (instrumental) activities of daily living (ADL and IADL), loneliness, and depressive symptoms. QoL (outcome) was assessed with the CASP-12 scale. Longitudinal model-based causal mediation analyses were performed to decompose the total association between multimorbidity and QoL into direct and indirect effects. Moderated mediation analyses tested for differences in mediation pathways by sociodemographic factors. Results Multimorbidity was significantly associated with lower QoL (direct effect: b = −0.66). This association was mediated by ADL limitations (percentage mediated 0.97%), IADL limitations (3.24%), and depressive symptoms (16.70%), but not by loneliness. The mediation pathways were moderated by age, education, financial strain, and gender. Discussion and Implications ADL, IADL, and depressive symptoms are crucial intermediary factors between multimorbidity and QoL in older European adults, with changing importance according to age, education, financial strain, and gender. The findings may help to increase the QoL of individuals with multimorbidity and redirect care efforts to these factors.
Are people really less moral in their foreign language? Proficiency and comprehension matter for the moral foreign language effect in Russian speakers

Previous work has demonstrated that people are more willing to sacrifice one person to save five in a foreign language (FL) than in their native tongue. This may be due to the FL either reducing concerns about sacrificial harm (deontological inclinations) or increasing concerns about overall outcomes (utilitarian inclinations). Moreover, proficiency in a foreign language (FL) may moderate results. To test these possibilities, we investigated the moral foreign language effect (MFLE) in a novel sample of Russian L1/English FL speakers. We employed process dissociation (PD)—a technique that independently assesses concerns about rejecting harm and maximizing outcomes in sacrificial dilemmas, and we assessed measures of objective and subjective foreign language proficiency and of dilemma comprehension. Results replicated the pattern of increased acceptance of sacrificial harm in FL demonstrated in earlier studies, but a PD analysis showed no evidence of increased concerns for utilitarian outcomes in a FL; instead, this pattern was driven by reduced concerns regarding sacrificial harm. However, people who reported better dilemma comprehension in the FL demonstrated both stronger deontological and utilitarian responding, and people with higher objective proficiency displayed stronger utilitarian responding in the FL than those with lower proficiency. These findings show that utilitarian inclinations are affected by reading dilemmas in a foreign language mainly in low-proficiency speakers, and that while emotional concerns for sacrifice are reduced in FL, better comprehension can increase such concerns as well as concern for outcomes.
How informed is informed consent?—Evaluating the quality of informed consent among surgical patients in a tertiary care hospital in Nepal

Background Informed consent-taking is a part of clinical practice that has ethical and legal aspects attached to it. This protects the autonomy of the patients by providing complete information regarding the rationale, modality, potential risks, benefits, and alternatives of the planned procedure to the patients. This enables the patients to make the right decision for themselves and their care. This study aims to find out if the informed consent-taking process has ensured the active participation of the patients or the next of kin in the decision-making. Materials and methods This is a prospective cross-sectional study conducted in a military healthcare institution among patients undergoing major surgical procedures from July 2022 to October 2022. Ethical clearance was obtained before the commencement of this study. A structured questionnaire was prepared, and the collected data was refined in Excel and imported into SPSS for analysis. Results A total of 350 individuals of mean age 47.95 ± 16.057 years were part of this study. The majority of the respondents were married, literate, and family by beneficiary category. All of the respondents received and signed the consent form. About 77% of the respondents read it completely, and 95.4% of them reported that it was understandable. The majority of the patients did not know who was going to perform the surgery, the alternatives to the planned treatment, the benefits of the surgery, or the outcome of non-treatment. On the patient satisfaction scale, 16.28% of the participants agreed that they were satisfied with the informed consent-taking process. Conclusion Deficiencies in the informed consent-taking process were the lack of dissemination of adequate information on the nature, duration, pros and cons, post-operative state, and alternative of the planned procedure. A well-structured format of the consent form that is specific to a particular procedure should be adopted, and various alternatives to it must be disseminated to the patient or the next of kin to improve the quality of the informed consent-taking process.