Miracle-dz/UniFAR-FTUs huggingface dataset:
Postoperative Outcomes of “Optic Capture” Technique of IOL Implantation In Pediatric Cataract Surgery

Purpose: To evaluate the efficacy of posterior continuous curvilinear capsulorhexis (PCCC) with optic capture of the posterior chamber intraocular lens (PC IOL) without anterior vitrectomy in preventing secondary opacification of the visual axis following pediatric cataract surgery in age more than 2 years. Methods: In a prospective evaluation, preoperative and postoperative visual acuity and refractive error were recorded. Intraoperative and postoperative complications were observed. The surgical technique was posterior curvilinear capsulorhexis with optic capture with three piece hydrophobic IOL (MA60AC) after cataract extraction. The incidence of posterior capsular opacification and other complications of pediatric cataract surgery were studied. The follow-up period was from 6 to 36 months. Results: In 75 consecutive eyes of 45 children operated with age range 2 to 8 years (mean, 3.3 years), there was no significant opacification of the visual axis at a mean follow-up of 19 months after surgery (range, 6-36 months). Conclusion: The posterior continuous curvilinear capsulorhexis with posterior optic capture with three-piece hydrophobic lens without anterior vitrectomy is safe and effective in the treatment of pediatric cataract in the prevention of secondary opacification of the visual axis.
Recall and Recognition in Alzheimer's Disease and Frontotemporal Dementia.

BACKGROUND It has long been debated whether performance on recall and recognition tests depends on the same or different memory systems and whether performance on these two tasks is dissociated in clinical populations. According to Dual process theories of recall, performance on recall and recognition tests dissociates in the relative reliance on frontal lobe related activities; in fact, the recall test requires more strategic retrieval of memoranda than the recognition task. By contrast, Dual process theories of recognition posit that performance on these tests differs in the relative contribution of recollection and familiarity memory processes in the two tasks: both recollection and familiarity contribute to recognition judgments, but only recollection supports recall performance. OBJECTIVE The aim of this study was to clarify the cognitive processes involved in recall and recognition in patients with dementia. METHODS We administered a 15-word recall task followed by a yes/no recognition paradigm to 28 patients with Alzheimer's disease (AD), 22 patients with the behavioral variant of frontotemporal dementia (bvFTD), and 45 normal controls (NCs). RESULTS Results showed that on the delayed recall task, bvFTD patients performed much better than AD patients but the two groups did not differ on any index of recognition performance. CONCLUSION The present data support the hypothesis that the performance of the two groups is expression of the different reliance on recollection (more impaired in the AD than in the bvFTD group) and familiarity (similarly impaired in the two groups) in performance on recall and recognition tasks.
Age-related fatty infiltration of lumbar paraspinal muscles: a normative reference database study in 516 Chinese females.

Background Fatty infiltration, as a result of aging, is an essential biomarker of muscle degeneration. This research aimed to investigate the age-dependent change of fatty degeneration in the paraspinal muscles of healthy Chinese women. This study also explores the effect of body size on fatty infiltration of paraspinal muscles. Methods Cross-sectional area of paraspinal muscles (CSAmuscle) and intermuscular adipose tissue (CSAIMAT) were measured at the L3 mid-vertebral level of 516 healthy females, who underwent abdomen quantitative computed tomography (QCT) scans. Subsequently, IMAT% [CSAIMAT / (CSAIMAT + CSAmuscle)] were calculated. The relationship between basic information and measurements was evaluated using Spearman correlations. Comparisons of QCT results among different BMI subgroups in different age groups were analyzed with the Kruskal-Wallis H test and LSD, post-hoc correction. Age-related changes were calculated after the adjustment of height and weight. Results The mean CSAIMAT of 20-29 years group (n=69) and 70-79 years group (n=25) were 3.00 cm2 and 11.06 cm2, respectively. While the mean CSAmuscle of 20-29 years group was 38.46 cm2 and 70-79 years group was 30.86 cm2. The mean IMAT% difference between 20-29 years group and 70-79 years group was -18.55%. Strong, positive non-linear associations were observed between ageing and CSAIMAT, along with IMAT% (r=0.656, P<0.01; r=0.714, P<0.01). However, CSAmuscle was shown to decrease with age in a weak, negative linear fashion (r=-0.265, P<0.01). Positive relationships between BMI and CSAIMAT, CSAmuscle, along with IMAT%, were found. Significant differences were observed between obesity and normal BMI subgroup for all variables in three age groups. CSAIMAT showed a larger age-related difference compared to CSAmuscle. Conclusions Fatty infiltration in paraspinal muscles increased with age and BMI, while muscle loss may be associated with aging. The present study provided standardized reference data for the fatty degeneration of paraspinal muscles across the adult lifespan of Chinese females, which will play a critical role in future studies.
Physiologic vasomotor symptoms are associated with verbal memory dysfunction in breast cancer survivors.

OBJECTIVE Vasomotor symptoms (VMS), sleep disturbance, and cognitive complaints are common among women with a history of breast cancer and contribute to decreased quality of life. Studies in healthy women showed an association between verbal memory performance and physiologic VMS measured with ambulatory skin conductance monitors but not with VMS by self-report. We hypothesized that we would find a similar association in women with breast cancer. METHODS Participants included 30 female breast cancer survivors (mean age 52.7 y; 26.7% African-American) with moderate-to-severe VMS enrolled in a larger clinical trial of a nonhormonal intervention for VMS. At baseline, participants completed assessments of physiologic VMS, actigraphy-based assessments of sleep, questionnaires about mood, and two tests of verbal memory - Logical Memory (LM) and the California Verbal Learning Test (CVLT). Using baseline data, we conducted multivariate regression analyses to examine the association between VMS and memory, controlling for sleep and other factors. RESULTS On average, women reported 46% of total physiologic VMS. A higher frequency of physiologic VMS - but not reported VMS - was significantly associated with lower scores on the California Verbal Learning Test short-delay free recall (r[28] = -0.41, P = 0.03), long-delay free recall (r[28] = -0.42, P = 0.03), and total clustering, (r[28] = -0.39, P = 0.04). These associations were independent of sleep, mood, and other factors. CONCLUSIONS Independent of their effect on sleep, VMS may be a modifiable contributor to memory difficulties in women with breast cancer. These findings underscore the importance of objective measurement of VMS in cognitive studies. : Video Summary:http://links.lww. com/MENO/A623.
Variation in Knowledge of Stroke Warning Signs by Age and Presence of Conventional Risk Factors

Background It is important to recognize stroke in the general public. Objectives The purpose of this study was to investigate factors affecting knowledge of stroke warning signs (SWSs) according to age group in the Korean population. Methods This study is a cross-sectional study. Using data from the Korean Community Health Survey conducted in Korea in 2017, 198 403 subjects were analyzed. Knowledge about SWSs was assessed by face-to-face interviews using structured close-ended questionnaires with 5 items about stroke symptoms (sudden unilateral weakness of face, arm or leg; sudden difficulty in speaking, or trouble understanding speech; sudden visual impairment in 1 eye, or double vision; sudden dizziness or loss of balance; and sudden severe headache). Results The overall percentage of subjects with good knowledge of SWSs (>4 correct answers to the SWS questionnaire) was 66.5%. It was highest in the middle-aged subjects (72.6%), followed by the young subjects (63.5%) and the older subjects (61.5%). The youngest of the young subjects and the oldest of the older subjects had the least knowledge. Subjects with conventional risk factors generally had more knowledge about SWSs, except for those with diabetes mellitus. However, in the young subjects, knowledge about SWSs was not increased by the presence of conventional risk factors such as hypertension and dyslipidemia. Conclusion Stoke risk factors are increasing among young people; they still have poor knowledge about SWSs. More education is needed to increase appropriate treatment, especially in young people with stroke-related risk factors.
A Tale of Two Livers.

C hk in D. ‘‘On a point of land, as though projecting into a domain beyond us, I found the star thrower. In the sweet rain-swept morning, that great many-hued rainbow still lurked and wavered tentatively beyond him. Silently I sought and picked up a still-living star, spinning it far out into the waves. I spoke once briefly. ‘‘I understand,’’ I said. ‘‘Call me another thrower. ’’ Only then I allowed myself to think, He is not alone any longer. After us there will be others. ’’ Loren Eiseley, The Unexpected Universe, San Diego, CA, Harcourt, Brace and World; 1969. In 2001, 524 living donor liver transplants (LDLT) were performed in the United States, representing 10.1% of all liver transplants that year. The death of a living donor in January 2002, coupled with expanded use of deceased donors, saw a steady decline in the number of LDLT to a nadir of 219 cases in 2009 (3.5% of all liver transplants). Indeed, the recovery of LDTL has taken as long as the fall, as we once again have reached 524 cases in 2019 (5.9% of all liver transplants). Despite the continued growth of LDLT, this modality still appears to remain an underutilized resource in the United States for those candidates awaiting liver transplantationnotably, in 2019, 2412 patients were removed from the waitlist due to death or being too sick for transplant. Further, of the 145 active liver transplant programs in the United States in 2019, only 58 (40%) performed a LDLT, and importantly only 17 of those 58 programs performed 10 or more in 2019. In contrast, of the 240 active kidney transplant programs, 222 (93%) performed living donor kidney transplants. The evolution of living kidney and living liver donation have shared some similar paths, albeit with kidney having a 35-year head start (1954 vs 1989). The use of a right kidney for donation (the shorter of renal veins) or a kidney with multiple arteries, the application of laparoscopic and then robotic techniques for kidney extraction, and the subsequent concept of kidney paired exchange (ie, a kidney swap) have allowed for the increased adoption of living donor kidney transplants (LDKT). Indeed, 6867 LDKT were performed in the US in 2019, representing 29.3% of all kidney transplants and the highest number to date. This success begs the questiondespite its added technical and logistical complexity, can LDLT achieve similar growth? We have seen the technical evolution from the left lateral segment graft to now the right or left
Large‐bore arterial access in the era of structural cardiovascular disease

Over the last two decades, the medical community witnessed an outstanding and accelerated development on minimally invasive therapies. The definition of what constitutes large bore access is subject to discussion, however within the field it is generally accepted to reflect a catheter diameter exceeding 8‐French. We sought in this review to explore the evolution, characteristics and vascular compatibility of the current commercially available devices, analyze the devices along with access site‐specific complications rates and finally review the present methods for percutaneous vascular closure.
Development of a high-risk neonatal infection control competency scale

The purpose of this study was to develop a scale to measure high-risk neonatal infection control competency among nurses in neonatal intensive care units (NICUs). The study participants included 251 nurses working in NICUs at seven hospitals in South Korea. The scale was designed to measure high-risk neonatal infection control competency in terms of performance (HirNICCS_P) and knowledge (HirNICCS_K), which were addressed by 42 and 54 items, respectively, and was initially subjected to content validity testing by a panel of experts in neonatal nursing. The items were divided into five factors: (1) basic care, (2) skin care, (3) feeding management, (4) medication and invasive procedures, and (5) environment management. After participant completion of the scale, construct validity was examined using exploratory and confirmatory factor analyses, and internal reliability tests were also performed. The total variance of validity was 53.7% for HirNICCS_P, and the Cronbach’s alpha values for reliability were . 95 for HirNICCS_P and . 67 for HirNICCS_K based on a Kuder–Richardson-20 test. We concluded that this scale can be used to assess the performance and knowledge with regard to infection control competency among neonatal nurses and that its application can support strengthening of infection control education for nurses who score low on performance and knowledge competency.
Períodos de semeadura e condições de armazenamento na qualidade de cozimento de grãos de feijão

The objective of the research was to evaluate the effect of sowing periods on cooking quality of common bean grains of the 'Perola' cultivar when stored under different temperatures, moisture content and storage times. A completely randomized design was applied, with three replications. The treatments were combinations of three sowing periods (10/15/2003, 10/29/2003 and 11/21/2003), three storage environment (environment temperature; 12°C of air temperature and 45-50% of moisture content; and 0.5°C of air temperature and 80% of moisture content); and three storage times (0, 3 and 6 months). The percentage of normal and hard grains was influenced by storage environment and storage time. The highest percentage of hard grains was verified in the three sowing period. The water imbibition was decreased after six months of the storage. The cooking time was not varied to storage time when sowings were made in 10/15/2003 and 10/29/2003. Highest time to water uptake and cooking can be necessary in function of the quality grain in moment harvesting or of the temperature and content moisture during storage.
lncRNA SNHG1 Knockdown Alleviates Amyloid-β-Induced Neuronal Injury by Regulating ZNF217 via Sponging miR-361-3p in Alzheimer's Disease.

BACKGROUND Long noncoding RNAs have been proven to play an important role in the progression of Alzheimer's disease (AD). However, the function of small nucleolar RNA host gene 1 (SNHG1) in AD progression remains to be studied. OBJECTIVE To explore the role of SNHG1 in AD progression and clarify its potential mechanism. METHODS Amyloid β-protein (Aβ) was used to construct an AD cell model in vitro. The expression levels of SNHG1 and miR-361-3p were determined by quantitative real-time polymerase chain reaction. Cell viability and apoptosis were measured by cell counting kit 8 assay and flow cytometry. The levels of apoptosis-related proteins and zinc finger gene 217 (ZNF217) protein were evaluated by western blot analysis. Additionally, the contents of inflammatory cytokines and oxidative stress markers were tested by enzyme-linked immunosorbent assay. Furthermore, dual-luciferase reporter and RNA immunoprecipitation assays were used to verify the interaction between miR-361-3p and SNHG1 or ZNF217. RESULTS Aβ could induce cell injury, while resveratrol could reverse this effect. SNHG1 expression was positively regulated by Aβ and negatively regulated by resveratrol. SNHG1 knockdown could reverse the promotion effect of Aβ on cell injury. Moreover, SNHG1 sponged miR-361-3p, and miR-361-3p targeted ZNF217. Additionally, miR-361-3p overexpression reversed the promotion effect of SNHG1 overexpression on cell injury, and ZNF217 silencing also reversed the promotion effect of miR-361-3p inhibitor on cell injury. CONCLUSION SNHG1 promoted cell injury by regulating the miR-361-3p/ZNF217 axis, which might provide a theoretical basis for molecular therapy of AD.
A pragmatic real-life study of flash glucose monitoring versus self-monitoring of blood glucose.

INTRODUCTION The aim of this study was to investigate if the flash glucose level monitoring system (FGM) is better than traditional self-monitoring of blood glucose level (SMBG) in helping patients in the outpatient clinic control their blood glucose and improve glycaemic control measured by the concentration of glycated haemoglobin (HbA1c). METHODS This was an observational real-life study based on data retrieved from a regional diabetes database and conducted in patients with Type 1 diabetes. HbA1c levels at baseline, and at six, nine and 12 months were compared in and between two groups counting 128 patients each. One group included patients who had recently started using the FGM system; the other patients who were using SMBG and otherwise following the routine protocol of the outpatient clinic. RESULTS We found no difference between the FGM group and the SMBG group with respect to age, sex, weight, diabetes duration or HbA1c at baseline. After six months, HbA1c had been reduced from 64 to 60 mmol/mol (p = 0.00) in the FGM group, whereas it remained unchanged in the SMBG group (from 63 to 63 mmol/mol, p = 0.66). According to the ANOVA repeated measures test, HbA1c measures showed a significant trend of reduction from 65 to 60 mmol/mol (p = 0.002) over 12 months in the FGM group and no trend of reduction in the SMBG group (from 63 to 64 mmol/mol, p = 0.386) Conclusions: Changing the blood glucose measuring method from SMBG to FGM helped patients with Type 1 diabetes in an outpatient clinic reduce their HbA1c. FUNDING none. TRIAL REGISTRATION not relevant.
Physical activity, obesity and sedentary behavior in cancer etiology: epidemiologic evidence and biologic mechanisms

An estimated 30–40% of cancers can be prevented through changes in modifiable lifestyle and environmental risk factors known to be associated with cancer incidence. Despite this knowledge, there remains limited awareness that these associations exist. The purpose of this review article was to summarize the epidemiologic evidence concerning the contribution of physical activity, sedentary behavior, and obesity to cancer etiology and to provide an overview of the biologic mechanisms that may be operative between these factors and cancer incidence. Strong and consistent evidence exists that higher levels of physical activity reduce the risk of six different cancer sites (bladder, breast, colon, endometrial, esophageal adenocarcinoma, gastric cardia), whereas moderate evidence inversely associates physical activity with lung, ovarian, pancreatic and renal cancer, and limited evidence inversely correlates physical activity with prostate cancer. Sedentary behavior, independent of physical activity, has been shown to increase the risk of colon, endometrial, and lung cancers. Obesity is an established risk factor for 13 different cancer sites (endometrial, postmenopausal breast, colorectal, esophageal, renal/kidneys, meningioma, pancreatic, gastric cardia, liver, multiple myeloma, ovarian, gallbladder, and thyroid). The main biologic mechanisms whereby physical activity, sedentary behavior, and obesity are related to cancer incidence include an effect on endogenous sex steroids and metabolic hormones, insulin sensitivity, and chronic inflammation. Several emerging pathways related to oxidative stress, DNA methylation, telomere length, immune function, and gut microbiome are presented. Key recommendations for future research in both the epidemiology and biology of the associations between physical activity, sedentary behavior, obesity, and cancer risk are also provided.
Building Emergency Medicine Trainee Competency in Pediatric Musculoskeletal Radiograph Interpretation: A Multicenter Prospective Cohort Study

As residency programs transition from time‐ to performance‐based competency standards, validated tools are needed to measure performance‐based learning outcomes and studies are required to characterize the learning experience for residents. Since pediatric musculoskeletal (MSK) radiograph interpretation can be challenging for emergency medicine trainees, we introduced Web‐based pediatric MSK radiograph learning system with performance endpoints into pediatric emergency medicine (PEM) fellowships and determined the feasibility and effectiveness of implementing this intervention.
Under‐reporting of COVID‐19 cases in Turkey

Summary Having an accurate account of the number of national COVID‐19 cases is essential for understanding the national and global burden of the disease and managing COVID‐19 prevention and control efforts. There is also substantial under‐reporting of COVID‐19 cases and deaths in many countries. In this article, the COVID‐19 under‐reporting problem in Turkey is addressed, and examples and reasons for the under‐reporting are discussed.
PILOT: Practical Privacy-Preserving Indoor Localization Using OuTsourcing

In the last decade, we observed a constantly growing number of Location-Based Services (LBSs) used in indoor environments, such as for targeted advertising in shopping malls or finding nearby friends. Although privacy-preserving LBSs were addressed in the literature, there was a lack of attention to the problem of enhancing privacy of indoor localization, i.e., the process of obtaining the users' locations indoors and, thus, a prerequisite for any indoor LBS. In this work we present PILOT, the first practically efficient solution for Privacy-Preserving Indoor Localization (PPIL) that was obtained by a synergy of the research areas indoor localization and applied cryptography. We design, implement, and evaluate protocols for Wi-Fi fingerprint-based PPIL that rely on 4 different distance metrics. To save energy and network bandwidth for the mobile end devices in PPIL, we securely outsource the computations to two non-colluding semi-honest parties. Our solution mixes different secure two-party computation protocols and we design size-and depth-optimized circuits for PPIL. We construct efficient circuit building blocks that are of independent interest: Single Instruction Multiple Data (SIMD) capable oblivious access to an array with low circuit depth and selection of the k-Nearest Neighbors with small circuit size. Additionally, we reduce Received Signal Strength (RSS) values from 8 bits to 4 bits without any significant accuracy reduction. Our most efficient PPIL protocol is 553x faster than that of Li et al. (INFOCOM'14) and 500x faster than that of Ziegeldorf et al. (WiSec'14). Our implementation on commodity hardware has practical run-times of less than 1 second even for the most accurate distance metrics that we consider, and it can process more than half a million PPIL queries per day.