Miracle-dz/UniFAR-FTUs huggingface dataset:
Exploring nurses’ experiences of value congruence and the perceived relationship with wellbeing and patient care and safety: a qualitative study

Background Values are of high importance to the nursing profession. Value congruence is the extent to which an individual’s values align with the values of their organisation. Value congruence has important implications for job satisfaction. Aim This study explored nurse values, value congruence and potential implications for individual nurses and organisations in terms of wellbeing and patient care and safety. Method Fifteen nurses who worked in acute hospital settings within the UK participated in semi-structured telephone interviews. Thematic analysis was utilised to analyse the data. Results Four themes were identified: organisational values incongruent with the work environment; personal and professional value alignment; nurse and supervisor values in conflict; nurses’ values at odds with the work environment. Perceived value incongruence was related to poorer wellbeing, increased burnout and poorer perceived patient care and safety. The barriers identified for nurses being able to work in line with their values are described. Conclusions Value congruence is important for nurse wellbeing and patient care and safety. Improving the alignment between the values that organisations state they hold, and the values implied by the work environment may help improve patient care and safety and support nurses in practice.
Reducing educational inequality through research-practice partnerships

Although researchers have done effective work at describing the inequities that plague schools, they have been less successful at making headway in addressing them, largely because their work remains disconnected from the schools that have to try to use the research. Through research-practice partnerships, researchers are able to stay in touch with the educators on the ground, craft research questions with their actual problems in mind, and help them take action in response to the research. Daniel Potter, Erin Baumgartner, and Ruth N. López Turley describe how, through the Houston Education Research Consortium, researchers from Rice University launched an equity project to uncover inequities within Houston-area schools and track their progress in addressing them. And, because of the ongoing relationship, they were able to launch a research project looking into how the COVID-19 pandemic affected students and produce results while schools where they were still relevant.
Tolerance and intolerance: Cultural meanings and discursive usage

The notion of tolerance is widely embraced across many settings and is generally considered critical for the peaceful functioning of culturally diverse societies. However, the concepts of tolerance and intolerance have various meanings and can be used in different ways and for different purposes. The various understandings raise different empirical questions and might have different implications for the subject positions of those who are tolerant and those who are tolerated. In this study, we focus on cultural understandings of tolerance and intolerance and how these terms are used in discourses. We first describe how in an open-ended question in a national survey lay people use a classical and a more modern understanding of tolerance to describe situations of tolerance and intolerance. Second, we analyze how those who tolerate and those who are tolerated can flexibly use these different understandings of (in)tolerance for discursively making particular “us–them” distinctions. It is concluded that the notions of tolerance and intolerance have different cultural meanings which both can be used for progressive or oppressive ends.
Prognostic rules for predicting cognitive syndromes following stroke: A systematic review

Purpose Stroke survivors are at high risk of developing cognitive syndromes, such as delirium and dementia. Accurate prediction of future cognitive outcomes may aid timely diagnosis, intervention planning, and stratification in clinical trials. We aimed to identify, describe and appraise existing multivariable prognostic rules for prediction of post-stroke cognitive status. Method We systematically searched four electronic databases from inception to November 2019 for publications describing a method to estimate individual probability of developing a cognitive syndrome following stroke. We extracted data from selected studies using a pre-specified proforma and applied the Prediction model Risk Of Bias Assessment Tool (PROBAST) for critical appraisal. Findings Of 17,390 titles, we included 10 studies (3143 participants), presenting the development of 11 prognostic rules – 7 for post-stroke cognitive impairment and 4 for delirium. Most commonly incorporated predictors were: demographics, imaging findings, stroke type and symptom severity. Among studies assessing predictive discrimination, the area under the receiver operating characteristic (AUROC) in apparent validation ranged from 0.80 to 0.91. The overall risk of bias for each study was high. Only one prognostic rule had been externally validated. Discussion/conclusion: Research into the prognosis of cognitive outcomes following stroke is an expanding field, still at its early stages. Recommending use of specific prognostic rules is limited by the high risk of bias in all identified studies, and lack of supporting evidence from external validation. To ensure the quality of future research, investigators should adhere to current, endorsed best practice guidelines for conduct of prediction model studies.
Risk of intracerebral haemorrhage from hypertension is greatest at an early age

Introduction The risk of intracerebral haemorrhage (ICH) associated with hypertension (HTN) is well documented. While the prevalence of HTN increases with age, the greatest odds ratio (OR) for HTN as a risk for ischemic stroke is at an early age. We sought to evaluate if the risk for ICH from HTN was higher in the youngest patients of each race. Patients and methods The Ethnic/Racial Variations of ICH (ERICH) study is a prospective multicenter case-control study of ICH among whites, blacks, and Hispanics. Participants were divided into age groups based on race-specific quartiles. Cases in each race/age group were compared to controls using logistic regression (i.e., cases and controls unmatched). The probability of ICH among cases and controls for each race were compared against independent variables of HTN, quartile of age and interaction of quartile and age also using logistic regression. Results Overall, 2033 non-lobar ICH cases and 2060 controls, and 913 lobar ICH cases with 927 controls were included. ORs were highest in the youngest age quartile for non-lobar haemorrhage for blacks and Hispanics and highest in the youngest quartile for lobar haemorrhage for all races. The formal test of interaction between age and HTN was significant in all races for all locations with the exception of lobar ICH in whites (p = 0.2935). Discussion Hypertension is a strong independent risk factor for ICH irrespective of location among persons of younger age, consistent with the hypothesis that first exposure to HTN is a particularly sensitive time for all locations of ICH.
The first diffusion of the Covid-19 outbreak in Northern Italy: an analysis based on a simplified version of the SIR model

Abstract In this paper an analysis of the first diffusion of the Covid-19 outbreak occurred in late February 2020 in Northern Italy is presented. In order to study the time evolution of the epidemic it was decided to analyze in particular as the most relevant variable the number of hospitalized people, considered as the less biased proxy of the real number of infected people. An approximate solution of the infected equation was found from a simplified version of the SIR model. This solution was used as a tool for the calculation of the basic reproduction number R 0 in the early phase of the epidemic for the most affected Northern Italian regions (Piedmont, Lombardy, Veneto and Emilia), giving values of R 0 ranging from 2.2 to 3.1. Finally, a theoretical formulation of the infection rate is proposed, introducing a new parameter, the infection length, characteristic of the disease.
Hydrodynamic and Clouding Behavior of Triton X‐100+SDS Mixed Micellar Systems in the Presence of Sodium Chloride

Surface tension, cloud point, viscosity, dye solublization, and dynamic light scattering (DLS) results on aqueous micellar solutions of nonionic surfactant Triton X‐100 (TX‐100) and anionic surfactant sodium dodecyl sulfate (SDS) in the absence and presence of NaCl are reported. Changes in the critical micelle concentration (CMC) with the composition of the two surfactants so determined were analyzed by applying Rubingh's regular solution theory to obtain the interaction parameter β (−3.81) showing synergism. The cloud point (CP) of TX‐100 solution decreases linearly with NaCl concentration up to 1.0 M but no substantial growth in micelles was observed. On the other hand, addition of a small amount of SDS in TX‐100 solution raised the cloud point above 100°C. In the presence of lower NaCl concentration, TX‐100 shows an initial decrease in CP followed by rapid increase. While at higher NaCl concentrations minima shift to higher concentration and no sharp increased in CP was observed. Here results are discussed in terms of dehydration of polyoxyethylene chain of TX‐100 by NaCl, formation of charged mixed micelles of TX‐100+SDS in water, and the screening effect by the NaCl in the mixed micellar solutions. Results are well supported by viscosity, dye solublization, and DLS measurements. Aggregation number was calculated theoretically by applying the Tenford formula.
Diabetes and COVID-19

Abstract Several factors are linked with a higher risk of mortality from Coronavirus disease-19 (COVID-19), including male gender, increased age, hypertension, diabetes mellitus, obesity, cardiovascular diseases, chronic obstructive pulmonary disease, and cancer. Hyperglycemic COVID-19 patients have severe clinical problems, increased ICU admittance, machine-driven ventilation, and a substantial rise in inflammatory markers. Among all patients, those with diabetes or hyperglycemia have a two- to four-fold increase in mortality and severity of COVID-19 than those without diabetes. The primary cause of mortality in COVID-19 patients with diabetes is compromised immune response to viral infections. Increased blood sugar level probably affects intracellular degradation of bacteria, neutrophil chemotaxis, and phagocytosis, thus improving viral binding affinity and entry and decreasing virus clearance. In addition, it has significant effects on the proteins by inducing glycosylation and altering the composition of complements, and glycosylation renders cells susceptible to viral inflammation and damage. The treatment of COVID-19 in patients with diabetes requires an integrated team approach to minimize the risk of medical complications and mortality. Moreover, physicians should adopt proactive strategies to care for persons with comorbidities. This strategy would help reduce the frequency of complications and mortality among patients and load on the healthcare system.
Farm Profitability as a Driver of Spatial Spillovers: The Case of Somatic Cell Counts on Wisconsin Dairies

Abstract We hypothesize that spatial spillovers among neighboring farms are not only driven by spatial proximity, but also by farm profitability considerations. This hypothesis is tested by examining the role of spatial spillovers in shaping somatic cell counts (SCC) on Wisconsin dairy farms. Results show that neighborhood links defined both in terms of geographic proximity and farm profitability give rise to spatial spillovers that affect SCC. Significant differences in the estimated spatial spillovers are observed when defining the neighborhood space in terms of both farm profitability and geographic proximity as opposed to geographic proximity alone, with the data favoring the former specification.
A new approach for the simultaneous improvement of fire retardancy, tensile strength and melt dripping of poly(ethylene terephthalate)

A kind of synthesized thermotropic liquid crystal copolyester containing phosphorus (PLCP) with high flame retardancy (oxygen index, 70%) has been used to prepare in situ reinforced PET composites that have both good flame retardancy and better mechanical properties than pure PET. The melt dripping behavior of PET was also improved.
Distribution and mitochondrial DNA tracing of the invasive Argentine ants (Linepithema humile) in South Korea

Argentine ants (Linepithema humile) are one of the world's most invasive species and were first reported in South Korea, near Busan Port in 2019. The distribution of their initial spread was investigated here from April to July 2020. In the invasion area, numerous nests and individuals were identified, indicating that they had settled and successfully invaded the habitat. To track the invasion of the Argentine ants we conducted haplotype analysis using COI, COII, and Cytb sequences of their mitochondrial DNA. The invasive ants had the same mitochondrial haplotype (H3) as Argentine ants from America (Chile, Ecuador, Bermuda) and East Asia (Japan). When comparing the import trade volumes at Busan port with the Argentine ant haplotypes from other countries, it was determined that the invasive ants may have originated from the United States or Japan. Numerous ecological and economic impacts due to their invasion and spread in other countries has previously been reported. Therefore, prompt control measures for the Argentine ants found at Busan port, at this relatively early stage of settlement, is required.
Structural Studies on Se and Te with Synchrotron Radiation to Megabar Pressures

By the use of energy dispersive X-ray diffraction with synchrotron radiation, pressure induced structural phase transitions and equations of state were studied on Se and Te in the extended pressure range up to 129 GPa. In contrast to a previous study on Se to 50 GPa, the higher resolution with synchrotron radiation in the present study allowed for an unambiguous identification of the structure for Se IV as rhombohedral (β-Po-type) with one atom in the rhombohedral unit cell, and thus, a close similarity to Te under pressure and Po at higher temperatures is reestablished.
Probiotics, Pre-biotics and Synbiotics in the Treatment of Pre-diabetes: A Systematic Review of Randomized Controlled Trials

Objectives: This study aimed to review the data from randomized controlled trials (RCTs) and identify evidence for microbiota's role and use of probiotics, pre-biotics, or synbiotics in pre-diabetes. Methods: RCTs of pro-, pre-, synbiotics for the treatment of pre-diabetes population will be summarized. We searched for EMBASE, MEDLINE, Web of Science, Cochrane Central, Clinical Trials (ClinicalTrials.gov) from inception to February 2021. Results: The gut microbiota influences host metabolic disorders via the modulation of metabolites, including short-chain fatty acids (SCFAs), the endotoxin lipopolysaccharides (LPS), bile acids (BA) and trimethylamine N-oxide (TMAO), as well as mediating the interaction between the gastrointestinal system and other organs. Due to the limited sources of studies, inconsistent outcomes between included studies. Probiotics can decrease glycated hemoglobin (HbA1c) and have the potential to improve post-load glucose levels. The supplementation of probiotics can suppress the rise of blood cholesterol, but the improvement cannot be verified. Pre-biotics are failed to show an evident improvement in glycemic control, but their use caused the changes in the composition of gut microbiota. A combination of probiotics and pre-biotics in the synbiotics supplementation is more effective than probiotics alone in glycemic control. Conclusion: In the current studies using probiotics, pre-biotics or synbiotics for the treatment of pre-diabetes, the benefits of modulating the abundance of gut microbiota were partially demonstrated. However, there is insufficient evidence to show significant benefits on glucose metabolism, lipid metabolism and body composition.
Increased Gas Production from Hydrates by Combining Depressurization with Heating of the Wellbore

To extract gas from hydrate reservoirs, it has to be dissociated in situ. This endothermic dissociation process absorbs heat energy from the formation and pore fluid. The heat transfer governs the dissociation rate, which is proportional to the difference between the actual temperature and the equilibrium temperature. This study compares three potential gas production schemes from hydrate-bearing soil, where the radial heat transfer is governing. Cylindrical samples with 40% pore-filling hydrate saturation were tested. The production tests were carried out over 90 min by dissociating the hydrate from a centered miniature wellbore, by either lowering the pressure to 6, 4, or 6 MPa with simultaneous heating of the wellbore to 288 K. All tests were replicated by a numerical simulation. With additional heating at the same wellbore pressure, the gas production from hydrates could, on average, be increased by 1.8 and 3.6 times in the simulation and experiments, respectively. If the heat influx from the outer bo.
Lithological and Topographic Impact on Soil Nutrient Distributions in Tectonic Landscapes: Implications for Pleistocene Human-Landscape Interactions in the Southern Kenya Rift

Tectonically active regions are characterized by complex landscapes comprising soils with heterogeneous physicochemical properties. Spatial variability of nutrient sources enhances landscape biodiversity and creates heterogeneous habitats potentially attractive for animals and humans. In this study, we analyze the role of geological processes in the distributions of soil nutrients in the southern Kenya Rift, a key region in the interpretation of early human-landscape interactions. Our aim is to determine how spatial variations in rock chemistry, as well as topographic gradients and localized zones of rock fracturing from tectonic faulting determine the distributions of plant-available soil nutrients in soils. We hypothesize that present-day soil nutrient levels reflect the long-term chemical and geomorphological characteristics of the landscape and underlying parent material, and that regions with high nutrient availability occur along pathways correlating with locations of hominin fossil sites. Analyses of 91 topsoil samples from the main geological units show that Calcium (Ca) deficiencies predominately occur in shallow soils developed on trachytic volcanic rocks and granitic gneisses, while high Ca levels are associated with basaltic parent material and sedimentary deposits of mixed sources. XRF analysis of rock samples confirms that CaO levels in trachyte rocks are significantly lower than those in basalts, and Ca mobilization in basalt is more effective than in trachyte. Along two toposequences in densely faulted basaltic and trachytic rocks, we observed slope dependent soil nutritional gradients and a systematic increase of the concentrations of Ca, Mg and SOC in topsoils of colluvial sediments downslope of active normal faults. Known hominin sites in the region are located either along corridors of long-term Ca availability or at short-term nutrient hotspots potentially related to active CO2 degassing along active fault zones. This implies a strategic advantage of Ca-rich regions for hominin subsistence strategies, such as provision of predictable constraints on the distribution and mobility of grazing animals in complex tectonic landscapes. Our study implies that geological processes impact nutrient distributions in the southern Kenya Rift. Results of this study have further implications for understanding the role of soils in the interpretation of hominin-landscape interactions in the early stages of human evolution.
The Effects of Transcranial Direct Current Stimulation on Dual-Task Interference Depend on the Dual-Task Content

Recently, some studies revealed that transcranial direct current stimulation (tDCS) reduces dual-task interference. Since there are countless combinations of dual-tasks, it remains unclear whether stable effects by tDCS can be observed on dual-task interference. An aim of the present study was to investigate whether the effects of tDCS on dual-task interference change depend on the dual-task content. We adopted two combinations of dual-tasks, i.e., a word task while performing a tandem task (word-tandem dual-task) and a classic Stroop task while performing a tandem task (Stroop-tandem dual-task). We expected that the Stroop task would recruit the dorsolateral prefrontal cortex (DLPFC) and require involvement of executive function to greater extent than the word task. Subsequently, we hypothesized that anodal tDCS over the DLPFC would improve executive function and result in more effective reduction of dual-task interference in the Stroop-tandem dual-task than in the word-tandem dual-task. Anodal or cathodal tDCS was applied over the DLPFC or the supplementary motor area using a constant current of 2.0 mA for 20 min. According to our results, dual-task interference and the task performances of each task under the single-task condition were not changed after applying any settings of tDCS. However, anodal tDCS over the left DLPFC significantly improved the word task performance immediately after tDCS under the dual-task condition. Our findings suggested that the effect of anodal tDCS over the left DLPFC varies on the task performance under the dual-task condition was changed depending on the dual-task content.
lncSAMM50 Enhances Adipogenic Differentiation of Buffalo Adipocytes With No Effect on Its Host Gene

Fat deposition is one of the most important traits that are mediated by a set of complex regulatory factors in meat animals. Several researches have revealed the significant role of long non-coding RNAs (lncRNAs) in fat deposition while the precise regulatory mechanism is still largely elusive. In this study, we investigated the lncRNA profiles of adipose and muscle tissues in buffalo by using the Illumina HiSeq 3000 platform. In total, 43,809 lncRNAs were finally identified based on the computer algorithm. A comparison analysis revealed 241 lncRNAs that are differentially expressed (DE) in adipose and muscle tissues. We focused on lncSAMM50, a DE lncRNA that has a high expression in adipose tissue. Sequence alignment showed that lncSAMM50 is transcribed from the antisense strand of the upstream region of sorting and assembly machinery component 50 homolog (SAMM50), a gene involved in the function of mitochondrion and is subsequently demonstrated to inhibit the adipogenic differentiation of 3T3-L1 adipocyte cells in this study. lncSAMM50 is highly expressed in adipose tissue and upregulated in the mature adipocytes and mainly exists in the nucleus. Gain-of-function experiments demonstrated that lncSAMM50 promotes the adipogenic differentiation by upregulating adipogenic markers but with no effect on its host gene SAMM50 in buffalo adipocytes. These results indicate that lncSAMM50 enhances fat deposition in buffalo and provide a new factor for the regulatory network of adipogenesis.