Miracle-dz/UniFAR-FTUs huggingface dataset:
Hypothermia-Associated Coagulopathy: A Comparison of Viscoelastic Monitoring, Platelet Function, and Real Time Live Confocal Microscopy at Low Blood Temperatures, an in vitro Experimental Study

Introduction Hypothermia has notable effects on platelets, platelet function, fibrinogen, and coagulation factors. Common laboratory techniques cannot identify those effects, because blood samples are usually warmed to 37°C before analysis and do not fully reflect the in vivo situation. Multiple aspects of the pathophysiological changes in humoral and cellular coagulation remain obscure. This in vitro experimental study aimed to compare the measurements of thromboelastometry (TEM), multiple-electrode aggregometry (MEA) and Real Time Live Confocal Imaging for the purpose of identifying and characterizing hypothermia-associated coagulopathy. Methods Blood samples were drawn from 18 healthy volunteers and incubated for 30 min before being analyzed at the target temperatures (37, 32, 24, 18, and 13.7°C). At each temperature thromboelastometry and multiple-electrode aggregometry were measured. Real Time Live Confocal Imaging was performed at 4, 24, and 37°C. The images obtained by Real Time Live Confocal Imaging were compared with the functional results of thromboelastometry and multiple-electrode aggregometry. Results Thromboelastometry standard parameters were impaired at temperatures below baseline 37°C (ANOVA overall effect, p < 0.001): clotting time was prolonged by 27% at 13.7°C and by 60% at 18°C (p < 0.044); clot formation time was prolonged by 157% (p < 0.001). A reduction in platelet function with decreasing temperatures was observed (p < 0.001); the area under the curve at 13.7°C was reduced by 96% (ADP test), 92% (ASPI test), and 91% (TRAP test) of the baseline values. Temperature-associated changes in coagulation were visualized with Real Time Live Confocal Imaging. Molecular changes such as the temperature-associated decrease in the fibrin network are paralleled by cellular effects like the lesser activity of the platelets as a result of decreased temperature. The maximum clot firmness (MCF) in TEM only changed slightly within the temperature range tested. Conclusion The inhibitory effects of temperature on clot formation were visualized with Real Time Live Confocal Microscopy and compared with standard point-of-care testing. Inhibition of clotting factors and impaired platelet function are probably a result of hypothermia-induced impairment of thrombin. Measurement of MCF in TEM does not fully concur with Real Time Live Confocal Microscopy or MEA in hypothermia.
MIXTURES OF ANNUAL CROPS FOR FORAGE IN CENTRAL ALBERTA

ing on both soils. Barley yielded less and was less competitive than oats. nailey-pea mrxtures produced higher yields than pure barley on Grey-wooded soil. Triticale and wheat were least competitive and produced low yields in mixtures. Average yields of sunflowers on Black soil were 3"3 times greater than on Grey-wooded soil, and yields were extremely variable over years. The effect of the relatively high fiber content of sunflowers at42% was reflected in their lower yields of aigesiiblJenergy. Legumes and their mixtures produced the highest yields of protein, with faba beans more pioductive on Black soil and peas better on Grey-Wooded soil. Usuatly the yields of mixtures were between or below the yields of components in pure stands.
PPARδ Attenuates Alcohol-Mediated Insulin Resistance by Enhancing Fatty Acid-Induced Mitochondrial Uncoupling and Antioxidant Defense in Skeletal Muscle

Alcohol consumption leads to the dysfunction of multiple organs including liver, heart, and skeletal muscle. Alcohol effects on insulin resistance in liver are well evidenced, whereas its effects in skeletal muscle remain controversial. Emerging evidence indicates that alcohol promotes adipose tissue dysfunction, which may induce organ dysregulation. We show that consumption of ethanol (EtOH) reduces the activation of 5′AMP-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) as well as the protein of carnitine palmitoyltransferase 1 (CPT1) and glucose transporter type 4 (GLUT4) in C2C12 myotube. We observed that chronic EtOH consumption increases free fatty acid levels in plasma and triglyceride (TG) accumulation in skeletal muscle and that these increases induce insulin resistance and decrease glucose uptake. Hence, ethanol dysregulates metabolic factors and induces TG accumulation. We found peroxisome proliferator-activated receptor β/δ (PPARδ) activation recovers AMPK activation and increases carnitine-acylcarnitine translocase (CACT) protein. These effects may contribute to enhance mitochondrial activation via uncoupling protein 3 (UCP3) when fatty acids are used as a substrate, thus reduces EtOH-induced increases in TG levels in skeletal muscle. In addition, PPARδ activation recovered EtOH-induced loss of protein kinase B (AKT) phosphorylation at serine 473 via rapamycin-insensitive companion of mammalian target of rapamycin (Rictor) activation. Importantly, PPARδ activation enhanced mitochondrial uncoupling via UCP3. Taken together, the study shows PPARδ enhances fatty acid utilization and uncoupled respiration via UCP3 and protects against EtOH-induced lipotoxicity and insulin resistance in skeletal muscle.
Ski Skating Race Technique—Effect of Long Distance Cross-Country Ski Racing on Choice of Skating Technique in Moderate Uphill Terrain

The aim of this study was to investigate the effect of prolonged ski racing using skating style on technique choice in a transition section among female and male high-level skiers. Fifty three national-to-elite level skiers (20 females: 26.7 ± 4.8 years, 167.0 ± 6.5 m, 61.0 ± 5.1 kg, and 75.5 ± 68.8 FIS points; 33 males: 25.2 ± 3.5 years, 179.0 ± 5.2 cm, 73.1 ± 5.7 kg, and 73.7 ± 63.2 FIS points) were video recorded along a flat-to-uphill transition section of a course during the 30-km (females) and 50-km (males) races at the 2018 Norwegian National Championships. Across laps, section speeds decreased (P < 0.001) in all skiers, with the best-ranked skiers faster than the lowest-ranked (P < 0.001), and males faster than females in the first and middle laps. Section speed within each lap was associated with race performance (r = 0.76–0.86, P < 0.001 in females and r = 0.87–0.89, P < 0.001 in males). The prevalence of Gear 2 (G2) increased, while Gear 3 (G3) use decreased (both P < 0.001) across the subsequent laps, with females preferring G2 more than males in lap one (P = 0.027). In long-distance skate-style skiing, transition performance is representative of race performance and skiers decrease the use of the often-faster G3 technique while increasing the use of the slower G2 technique due to prolonged exercise. Especially female skiers should consider adding some flat-to-uphill G3 practice into established training, specifically early in the session before fatigue may occur.
Phosphate Homeostasis − A Vital Metabolic Equilibrium Maintained Through the INPHORS Signaling Pathway

Cells face major changes in demand for and supply of inorganic phosphate (Pi). Pi is often a limiting nutrient in the environment, particularly for plants and microorganisms. At the same time, the need for phosphate varies, establishing conflicts of goals. Cells experience strong peaks of Pi demand, e.g., during the S-phase, when DNA, a highly abundant and phosphate-rich compound, is duplicated. While cells must satisfy these Pi demands, they must safeguard themselves against an excess of Pi in the cytosol. This is necessary because Pi is a product of all nucleotide-hydrolyzing reactions. An accumulation of Pi shifts the equilibria of these reactions and reduces the free energy that they can provide to drive endergonic metabolic reactions. Thus, while Pi starvation may simply retard growth and division, an elevated cytosolic Pi concentration is potentially dangerous for cells because it might stall metabolism. Accordingly, the consequences of perturbed cellular Pi homeostasis are severe. In eukaryotes, they range from lethality in microorganisms such as yeast (Sethuraman et al., 2001; Hürlimann, 2009), severe growth retardation and dwarfism in plants (Puga et al., 2014; Liu et al., 2015; Wild et al., 2016) to neurodegeneration or renal Fanconi syndrome in humans (Legati et al., 2015; Ansermet et al., 2017). Intracellular Pi homeostasis is thus not only a fundamental topic of cell biology but also of growing interest for medicine and agriculture.
Pretarsus and distal margin of the terminal tarsomere as an unexplored character system for higher‐level classification in Cholevinae (Coleoptera, Leiodidae)

Cholevinae are well founded as a monophylum, but their internal phylogenetic relationships constitute a matter of longstanding dispute. The morphology has been the main source of information in most available phylogenetic studies on the subfamily. Most of the characters used, however, were limited to easily visible external structures and genitalia. Here we investigate the informative power of an unexplored character system for the higher‐level systematics of Cholevinae: the morphology of the pretarsus and distal margin of the terminal tarsomere. We analysed and documented these structures in representatives of the five most species‐rich tribes of Cholevinae (encompassing 13 subtribes) using scanning electron microscopy. We identified several diagnostic features and recognize potential synapomorphies at the tribal, subtribal and generic levels. The architecture of the median and empodial sclerites (including the empodial setae), the shape and composition of the medial projection of the distal margin of the terminal tarsomere, and the armature of the claws were considered a promising source of information for delimiting tribes and subtribes. Our data challenge the traditional view of a close proximity of Eucatopini and Ptomaphagini as well as a previously suggested synapomorphy of Leptodirini, and reinforce the monophyly of Ptomaphagini. This contribution is one of the rare comparative studies on the coleopteran pretarsus and one of very few evaluating the systematic usefulness of the distal margin of the terminal tarsomere in insects.
Phylogenetic analysis indicates transitions from vegetative to sexual reproduction in the Lobaria retigera group (Lecanoromycetidae, Ascomycota)

Abstract Phylogenetic relationships among the hypothetical species pairs Lobaria kurokawae / L. retigera and L. pseudopulmonaria / L. isidiosa were investigated based on TLC techniques and the phylogenetic analysis of the internal transcribed spacers (ITS) nrDNA. Results of TLC demonstrate that L. retigera and L. kurokawae can be chemically distinguished from L. isidiosa and L. pseudopulmonaria by the absence of retigeranic acid. Parsimony analysis of 18 specimens shows two monophyletic clades – a L. retigera lineage and a L. isidiosa lineage—both including their apotheciate counterparts. Unlike the original hypothesis of species pairs, our study reveals transitions from isidiate morphs that have the potential to rarely form apothecia, towards apotheciate morphs that produce no vegetative propagules.
Haematological characteristics of Brazilian Teleosts: III. Parameters of the hybrid tambacu (Piaractus mesopotamicus Holmberg x Colossoma macropomum Cuvier) (Osteichthyes, Characidae)

Fifty six specimens of the hybrid "tambacu" (Piaractus mesopotamicus Holmberg, 1887 male x Colossoma macropomum Cuvier, 1818 female) were collected from fishfarm of Guariba, Sao Paulo, to evaluate their haematology. Fishes presented 400.0 to 3,100.0 g total weight and 20.0 to 52.0 cm total length. Haemoglobin, haematocrit, mean corpuscular haemoglobin content (MCHC) and percentage of defense blood cells including leucocytes and thrombocytes, were studied. Statistical analysis showed positive correlation (P<0.01) between haematocrit, MCHC and haemoglobin rate. Nevertheless, thrombocytes and lymphocytes showed negative correlation (P<0.01).
Past and recent sperm whales sightings in the Azores based on catches and whale watching information

The sperm whale, Physeter macrocephalus, was the most captured great whale in the Azores Archipelago by land-based whaling and nowadays is the most appealing species for whale watching, one of the archipelago’s principal sources of tourism. Our objective was to compare number of sightings during whaling and whale watching activities. Our main question to address the possible impact of past whaling in recent whale watching is: does a present-day eco-tourist sight more or fewer sperm whales than a whaler could sight in the past? For that, a compilation of data resulting both from past whaling records and recent whale watching records was conducted. We obtained a total of 727 independent sightings of sperm whales during a total of 280 different days of sperm whaling between 1947 and 1973. A total of 1767 sperm whale sightings were made during 1133 days of whale watching activities, between 1997 and 2008. The sperm whale sighting per unit of effort average was significantly higher in the past (35.68) than in the present (12.06). In the Azores, captures over the decades greatly decreased the number of sperm whales in the region and twenty years after the end of sperm whaling a reduced number of recent sightings were found.
“Our ladies” versus “our dominators”: Gender differences and nationalist discourse in the Polish Olympic coverage

Abstract The article presents differences in describing sportspeople during the last four Olympic Games in terms of gender and nationality in Polish newspapers. The fundamental goal of the research was to perform the quantitative and qualitative comparison of press materials from four Olympics (Vancouver 2010, London 2012, Sochi 2014, Rio de Janeiro 2016). The content analysis was used for the quantitative part of the study and critical discourse analysis of two newspapers (the broadsheet and tabloid) in Poland for qualitative part. 712 media articles were analyzed. Our analysis has revealed significant underrepresentation of women and also differences in the description of rival competitors as well as overrepresentation of articles about Polish representatives during the Olympics. Those articles dwelt on the issue of nationality much more often and were more emotionally charged. Also, to a great extent, the performance of non-Polish women athletes was left unconsidered. The authors therefore indicate the validity of combining gender analysis and nationality in the context of the Olympic Games.
Achieving innovative firm performance through human capital and the effect of social capital

Abstract For the past decade, human capital has been recognized as one of the crucial assets of any firm’s overall performance. Previous studies widely advocated a linear link between human capital and innovative firm performance, arguing that there are a variety of factors to examine if the relationship between human capital and innovative firm performance is to be properly understood. The focus of this study was to examine the effect of social capital on the relationship between human capital and innovative firm performance. Specifically, it examined the relationship between human capital and social capital and between human capital and innovative firm performance. It also examined the relationship between social capital and innovative firm performance. A total of 294 questionnaires were obtained from managerial staff in automotive companies in Malaysia and the data was analysed using the Partial Least Squares (PLS) test. The results indicated a direct effect between human capital and innovative performance. It was found that human capital is significantly related to social capital and that there is a significant relationship between social capital and innovative firm performance, indicating the ability of social capital to improve innovative firm performance. Finally, it revealed that innovative firm performance could be achieved by human capital through the role of valuable social capital and that good innovative firm performance leads to more prudent and sustainable organisations. The results provide pertinent implications for academia, policymakers and market players while also contributing to the research fields of strategic management, human capital, social capital and performance.
Movements and Resource Selection of the Northern Long-eared Myotis (Myotis septentrionalis) in a Forest–Agriculture Landscape

Abstract The fragmentation of forests by the expansion of agriculture is recognized as an important factor influencing worldwide declines of forest-dependent species. Species that are forest dependent may be especially vulnerable to fragmentation because they have specialized resource requirements and may exhibit lower mobility in an agricultural matrix. We investigated movement patterns and resource selection of forest-dependent northern long-eared myotis (Myotis septentrionalis) in a forest–agricultural landscape on Prince Edward Island, Canada. Radiotelemetry was used to locate day-roosts and to estimate locations of female bats during nightly foraging bouts. Day-roost locations and foraging areas were mapped using a geographic information system to generally characterize the forest cover of foraging and roosting areas. Vegetative structure and insect prey availability were measured in the field and compared between foraging and roosting areas to describe resource selection at these sites. Movements of female northern long-eared myotis were constrained to forest features and foraging areas were concentrated along forest-covered creeks with bats roosting predominantly in deciduous trees within the same forest fragment, although bats at 1 site seemed to exclusively use a barn during late pregnancy and lactation. Differences in prey availability did not explain the spatial segregation of roosting and foraging areas. Relative to roost areas foraging sites were more likely to be close to forested creeks and densely forested areas, whereas roost sites were characterized by the availability of potentially suitable roosts. This study demonstrates the importance of investigating movements and resource selection of individuals in fragmented landscapes because a specialization on forest resources can highly restrict the vagility of forest-dependent species to a local environment.
Changes over time in the adaptation of barley releases in north-eastern Spain

The objective of this study was to characterize grain yield and adaptation of barley cultivars released in recent decades in north-eastern Spain. Ten six-rowed and 10 two-rowed barley genotypes were grown in eight environments. Mean yields varied among environments between 1.7 and 5.8 t.ha -1 . New releases showed higher mean yields and were specifically adapted to nonlimiting growing conditions. The average genetic advances were estimated as 40.7 and 32.9 kg.ha -1 . years -1 for two- and six-rowed genotypes, respectively, in the four most productive environments. Old genotypes, with lower overall grain yields, were specifically adapted to the poorer sites. A negative genetic gain, estimated as - 14.8 kg.ha -1 . years -1 , was recorded for six-rowed cultivars in the four poorest sites. No significant association was observed between heading date and year of release. Variations in carbon isotope discrimination (A) were examined to assess whether changes in adaptation could be partially explained by shifts in the genotypic transpiration efficiency (TE) over time. In the most favourable environments, new releases showed the highest grain yields and carbon isotope discrimination values (A). By contrast, older cultivars had constitutively lower Δs and therefore higher TEs. These results suggest a genetic association between low TE and yield potential and specific adaptation to stress-free conditions so that selection for yield under favourable conditions could have resulted in an indirect downward genetic shift in the TE of modern cultivars.
Demand Forecasting of Retail Sales Using Data Analytics and Statistical Programming

Abstract Forecasting the demand of network of retail sales is a rather challenging task, especially nowadays where integration of online and physical store orders creates an abundance of data that has to be efficiently stored, analyzed, understood and finally, become ready to be acted upon in a very short time frame. The challenge becomes even bigger for added-value third party logistics (3PL) operators, since in most cases and demand forecasting aside, they are also responsible for receiving, storing and breaking inbound quantities from suppliers, consolidating and picking retail orders and finally plan and organize shipments on a daily basis. This paper argues that data analytics can play a critical role in contemporary logistics and especially in demand data management and forecasting of retail distribution networks. The main objective of the research presented in this paper is to showcase how data analytics can support the 3PL decision making process on replenishing the network stores, thus improving inventory management in both Distribution Centre (DC) and retail outlet levels and the workload planning of human resources and DC automations. To do so, this paper presents the case of a Greek 3PL provider fulfilling physical store and online orders on behalf of a large sporting goods importer operating a network of 129 stores in five different countries. The authors utilize the power of ‘R’, a statistical programming language, which is well-equipped with a multitude of libraries for this purpose, to compare demand forecasting methods and identify the one producing the smallest forecast error.
Water Deficit Affects the Accumulation of Capsaicinoids in Fruits of Capsicum chinense Jacq.

The pungency of chili peppers is conferred by compounds called capsaicinoids thatareproducedonlyinthefruitsoftheCapsicumgenus.Accumulationofcapsaicinoids in these fruits may be affected by environmental conditions such as water and nutrient stresses, although these effects may vary even among genotypes within a species. The Habanero pepper (Capsicum chinense Jacq.), grown in the Yucatan, is in especially high demand as a result of its unique flavor, aroma, and pungency and is the second most important commercial crop in the state after the tomato. Although the Habanero pepper is a significant economic resource for the region, few studies have investigated the effects of abiotic stresses on capsaicinoid production. In this study, the effects of water stress on plant growth,capsaicinoid accumulation, andcapsaicinsynthase activitywere evaluated. Habanero pepperplantsunderwater stress hadalowerheight,rootdryweight,androot/ shoot relation than control plants, which were irrigated daily. However, fruit growth and production were unaffected by water stress. Capsaicin and dihydrocapsaicin concentra- tions increased in fruits of stressed plants compared with control plants, and this effect wascorrelatedwithfruitage.However,capsaicinsynthaseactivitywasreducedinresponse to water stress, and this effect depended on both stress severity and fruit age. These results provide new information on the regulation of capsaicinoid metabolism in response to abiotic stress from the fruit of a highly pungent chili pepper.