Miracle-dz/UniFAR-FTUs huggingface dataset:
Evaluation of vitamin D levels in children hospitalized with symptoms suggesting metabolism disorders in skeleton system

Introduction. Commonly occurring vitamin D deficiency in children can significantly influence the development of their skeleton. Objectives. Aim of the study is to evaluate the relationship between serum vitamin D levels and the occurrence of the skeleton system disorders in children at different developmental periods. Material and methods. The study included 1007 children aged 0-18 years (471 girls and 538 boys) who were hospitalized in the Department of PropedeuticsPaediatrics and Metabolic Bone Diseases, Medical University of Lodz in 2011–2015. Patients were divided into 6 groups: group I – 0–12 months, group II – 1–3 years, group III – 4–6 years, group IV – 7–10 years, group V – 11–14 years and group VI – 15–18 years. For each patient, the concentration of hydroksycholekacyferolu (25OHD) in serum was measured with chemiluminiscent immunoassay technology. Vitamin D deficiency was diagnosed at a concentration 25OHD ≤ 30 ng/ml. Results. 721 of children (71.59%) had vitamin D deficiency, more often boys. There was an increased incidence of vitamin D deficiency with age. Average concentrations of 25OHD reaches ≥ 30 ng/ml only in August Klinika Propedeutyki Pediatrii i Chorób Metabolicznych Kości Uniwersytetu Medycznego w Łodzi 1Centralny Szpital Kliniczny Uniwersytetu Medycznego w Łodzi, Ośrodek Pediatryczny im. M. Konopnickiej Evaluation of vitamin D levels in children hospitalized with symptoms suggesting metabolism disorders in skeleton system Department of Paediatric Propedeutics and Bone Metabolic Diseases Medical University of Lodz 1M. Konopnicka Pediatric Centre, Central Hospital of the Medical University od Lodz
Comparative Evaluation of Sucralfate and Honey in Oral Mucositis amongst Patients of Head and Neck Cancers Receiving Radiotherapy and Concurrent Chemotherapy

Head and neck cancer (HNC) is a term used to describe malignant tumours originating in the upper aerodigestive tract, including the oral cavity, larynx, pharynx and nasopharynx. Majority (90%) of cancers are squamous cell carcinomas arising from epithelial mucus membrane. 1 HNCs are among the ten most frequent cancers and are the sixth most common cancers worldwide. They constitute five percent of all cancers accounting for more than 550,000 cases annually. 2,3
Rescue Ebola Patients in silico

Ebola, one of the most pathogenic and lethal viruses, repeatedly leads to severe outbreaks with large numbers of casualties. By integration of data of fatal, non-fatal and asymptomatic cases, we developed a mathematical model of the immune response to Ebola infections and found that TNF-α can explain subsequent cytokine responses and allows to quantitatively stratify patients into survivors and fatal cases. The model further suggests that antibodies provide the key resolving mechanism in survivors while IFN-γ is the key defense mechanism in fatal cases. Exogenous IFN-γ and inhibition of excessive inflammation have the potential to rescue fatal Ebola infections in silico. In view of the high mortality of this disease, limited real life studies, and the unforeseeable next outbreak, our in silico analysis is meant as a guide for future research by the determination of the most efficient strategies for Ebola treatment.
Influence of relative humidity on the non-linear failure and stability of gypsum mines

Abstract A cusp catastrophic model was developed for the pillar-and-roof support system based on the simplified mechanical model of the support system and the improved stress-strain relationship for gypsum. Then, the catastrophic failure mechanism was investigated for the gypsum support system by considering the influence of relative humidity (RH). Meanwhile, the failure criterion for catastrophic instability in the gypsum support system was deduced, and the expression for the safety factor of the pillars was improved by considering the shape and size effects on the strength of gypsum. The results indicate that the RH exerts a significant influence on the catastrophic control parameters for the gypsum support system: with the increase of the RH, the catastrophic control parameters are more prone to cross the bifurcation set and meet the conditions of catastrophic instability for this system. For the input parameters used in the failure criterion, the RH mainly degrades the uniaxial compression strength and then causes catastrophic instability. According to the stability analysis for the mined-out area of the Jingmen Gypsum mines, the lower limit (about 1.60) of the value of factor relating the size effect to the uniaxial compression strength was obtained.
ANALISIS CASH HOLDING BERBASIS KEKUATAN KAS DAN MODAL KERJA BERSIH

This study aims to determine the effect of cash flow, cash conversion cycle, and networking capital on cash holding both partially and simultaneously. The population used in this study were 21 food and beverages sub-sector companies listed on the Indonesia Stock Exchange in the 2014-2018 period. The sample used uses the purposive sampling method. The data analysis technique used is the method of multiple regression analysis with a significant level and hypothesis testing using the F test and t-test. From the results of the study, it can be concluded that cash flow has no effect on cash holding. Cash conversion cycle variable has a significant negative effect on cash holding. The variable net working capital has a significant positive effect on cash holding. While simultaneous variables of cash flow, cash conversion cycle, and networking capital affect the cash holding of food and beverages sub-sector companies listed on the Indonesia Stock Exchange in the 2014-2018 period.
Nitel Araştırma Dersinin Lisansüstü Öğrenciler ve Öğretim Elemanlarınca Bütüncül Olarak Değerlendirilmesi

Bu calisma ile bir devlet universitesi egitim fakultesinde Egitim Bilimleri Bolumunde verilen Nitel Arastirma Yontemleri dersini alan lisansustu ogrenciler ile bolumde bu dersi veren ogretim uyelerinin bakis acisindan nitel arastirma derslerinin farkli degiskenlere gore derinlemesine degerlendirilmesi amaclanmistir. Calismaya, ilgili universitenin Egitim Bilimleri Ana Bilim Dalinda, gonulluluk esasina dayali olarak 18 lisansustu ogrenci ile bu dersi veren 3 ogretim uyesi katilmistir. Veri cesitlemesi saglanmasi bakimindan veriler gorusme, gozlem ve dokumanlar yoluyla elde edilmistir ve verilerin analizinde icerik analizinden yararlanilmistir. Arastirma sonucunda lisansustu ogrencilerin nitel arastirma yontemlerini egitim bilimlerin alaninda onemli gordukleri; dersin islendigi fiziksel ortama yonelik olumsuz goruslerin yer aldigi; dersin islenisinde arac-gerec ve materyal olarak en cok bilgisayar, projeksiyon, tez, makale ve kitaplarin kullanildigi; dersin bir izlencesinin var olmasinin olumlu bulundugu; gozlem konusuna daha fazla agirlik verilmesi gerektigi; degerlendirilmede ogrenci sunumlarina, urun odakli calismalarina, okul disi odevlendirmelere ve sinavlara yer verildigi sonucuna ulasilmistir.
θω−Connectedness and ω−R1 properties

We use the theta omega closure operator to define theta omega connectedness as a property which is weaker than connectedness and stronger than θ-connectedness. We give several sufficient conditions for the equivalence between θω-connectedness and connectedness, and between θω-connectedness and θ-connectedness. We give two results regarding the union of θω-connected sets and also we show that the weakly θω-continuous image of a connected set is θω-connected. We define and investigate V -θω-connectedness as a strong form of V - θ-connectedness, and we show that the θω-connectedness and V -θω-connectedness are independent. We continue the study of R1 as a known topological property by giving several results regarding it. We introduce ω-R1 (I), ω-R1 (II), ω-R1 (III) and weakly ω-R1 as four weaker forms of R1 by utilizing ω-open sets, we give several relationships regarding them and we raise two open questions.
Is the recent increase in national homicide abnormal? Testing the application of fan charts in monitoring national homicide trends over time

Purpose: The goal of this study is to compare the increase in the 2015 national homicide rate to the historical data series and other violent crime rate changes. Methods: We use ARIMA models and a one-step ahead forecasting technique to predict national homicide, rape, robbery, and aggravated assault rates in the United States. Annual Uniform Crime Report data published by the Federal Bureau of Investigation are used in our analysis. Results: The 2015 homicide rate increased above the 90% prediction interval for our model, but not more conservative intervals. Predictions intervals for other national level crime rates consistently produced correct coverage using our forecasting approach.Conclusions: Our findings provide weak evidence that the national homicide rate spiked in 2015, though data for 2016 – 2018 do not show a continued anomalous increase in the U.S. homicide rate. Data and code to replicate the findings can be downloaded from https://www.dropbox. com/sh/3086vtoqly5qho6/AABq_weh2LTMtBp426vhZ0EHa? dl=0
PENGARUH PENGGANTIAN TEPUNG IKAN DENGAN TEPUNG LARVA Hermetia illucens dan Azolla sp. TERHADAP KUALITAS PAKAN IKAN TERAPUNG

Saat ini harga tepung ikan yang merupakan sumber protein utama terus mengalami kenaikan sehingga dibutuhkan sumber protein lainnya yang bisa mengganti peran tepung ikan dalam pakan ikan terapung. Tujuan dari penelitian ini adalah untuk mengetahui pengaruh bahan pengganti tepung ikan terhadap kualitas fisik pakan. Bahan yang digunakan ialah tepung larva Hermetia illucens dan tepung Azolla sp. Metode penelitian menggunakan rancangan acak lengkap (RAL) dengan formula pakan yang berbeda yaitu perbandingan tepung ikan dengan tepung larva H. illucens atau Azolla sp. berturut-turut 100%:0%; 75%:25%; 50%:50%; dan 25%:75%. Parameter yang diamati meliputi kadar protein, rasio pengembangan, unit density, daya apung, dan kekerasan pakan. Hasil penelitian menunjukkan penggantian tepung ikan dengan tepung larva dalam formula menghasilkan kadar protein yang tidak berbeda nyata, berkurangnya rasio pengembangan, meningkatnya unit density, turunnya daya apung, dan meningkatkan kekerasan pakan. Sedangkan penggantian dengan tepung Azolla sp. memberikan efek terhadap turunnya kadar protein, turunnya rasio pengembangan dan kekerasan pakan namun tidak berpengaruh terhadap unit density dan daya apung pakan. Berdasarkan hasil ini tepung Azolla memiliki potensi sebagai pengganti sebagian tepung ikan dalam pembuatan pakan ikan terapung. Fish meal prices continue to increase, which has led to research efforts of finding other protein sources to replace fish meal in floating fish feed. The purpose of this study was to determine the effects of alternative fish meal replacements on the physical quality of feed. Alternative replacement ingredients were Hermetia illucens larval meal and Azolla meal. The research method used a completely randomized design (CRD) consisted of different ratios of fish meal with H. illucens larval meal and Azolla meal combination of 100%:0%, 75%:25%, 50%:50%, and 25%:75%, respectively. The parameters observed included protein content, expansion ratio, unit density, floatability, and hardness of feed. The study found that the larval meal produced similar protein content, reduced expansion ratios, increased unit density, decreased floatability and increased hardness of feed. The replacement of fish meal with Azolla meal had decreased the protein content, expansion ratio, and hardness of the feed. However, the substitution did not affect the unit density and floatability of feed. Based on this result Azolla meal has potential as replacement of fish meal partially in producing floating fish meal.
Nonlinear analysis of unreinforced beam-column joints

Introduction- Reinforced Concrete Frames (RCF) constitute a significant portion of the building stock in areas with seismic hazard. Many older buildings of this type were designed and constructed with little or no consideration of lateral load effects. When not properly designed, the Beam-Column Joints (BCJ) can be the weak links in the RCF. Unreinforced BCJ are still quite prevalent in older-type construction especially in Asia and Latin America. The unreinforced BCJ are key components that have a significant impact on the structure’s behavior of RCF. Regarding the analytical approaches applicable to BCJ, the approaches range from simplified to more elaborate and phenomenological-oriented. Unfortunately, most of them lack of simplicity, numerical stability and practicality to robustly evaluate the performance of unreinforced BCJ. This paper presents an analytical approach to modeling unreinforced BCJ. Objective- The aim of this paper is to present a modified modeling approach to simulate the nonlinear behavior of unreinforced BCJ in RCF structures. Method- The approach presented is based on the model presented in [1]. The model was modified to follow the same nomenclature of the [2]. In the proposed approach, the BCJ subassembly is represented by (1) a set of rigid links placed in cross-shape are used to represent the joint geometry, (2) a zero-length element with an empirical quad-backbone curve, placed at the middle point of the rigid links, to represent the joint shear behavior, and (3) columns and beams elements modeled with fiber formulation and five integration points to capture the material nonlinearity of the elements that frame into the joint. The approach was implemented in the OpenSEES platform, and this was validated with 13 test results of unreinforced BCJ documented in the literature. Results- The proposed modelling approach can satisfactorily predict the joint shear capacity. A 2% difference and a standard deviation of about 11% were obtained when compared to 13 test results of unreinforced BCJ documented in the literature. In terms of cyclic behavior, the proposed modelling approach shown to adequately capture the initial stiffness, strength degradation, reloading stiffness, pre-capping, and post-capping capacity. Conclusions- The method proposed presents satisfactory agreement with the test results analyzed. Taking into account the minor modifications applied to the proposed method and the uncertainties associated with the materials, test measurements, test setup, and the tolerances, the proposed method can satisfactorily predict the unreinforced BCJ shear capacity in RCF structures. It is assumed that the procedures presented here will contribute in the incorporation of the unreinforced BCJ flexibility when modeling older-type RCF construction in a pragmatic manner.
Mechanism by which Metformin Influence Metabolic Changes in Human:A Systematic-Review

Metformin is the most widely used oral antihyperglycemic agent for the improvement of type 2 diabetes mellitus (T2DM). In patients with T2DM, metformin increases insulin sensitivity and reduces glucose production. In this systematic review, we identified and compared metabolic changes induced by metformin administration. We searched articles published within the past 5 years on Pubmed.gov by using the keywords “metformin and metabolomics. ” No restrictions were placed on the languages, species, or gender during the selection of articles. From the 29 identified articles, we excluded non-human in vivo or in vitro studies, studies in cancer patients, and studies in which the focus was not on variation in the levels of metabolites after administration of medication such as pharmacogenetic studies. Finally, we selected 8 articles and compared their results. In the selected study results, a treatment with metformin and a combination of metformin and other anti-diabetic agents decreased the levels of phenylalanine, tyrosine, lysine, and glutamate to 5.58 ± 2.23%, 11.50 ± 2.12%, 25.28 ± 27.90%, and 35.49 ± 26.18% (mean ± SD), respectively, but increased the levels of alanine to 16.00% in 3 months-5 years of follow-up after metformin treatment compared to the control. The levels of total cholesterol and low-density lipoprotein (LDL) cholesterol (5.28%) decreased, whereas those of high-density lipoprotein (HDL) cholesterol increased by 34.65% in 18–30 months of follow-up after administration of metformin. Metformin administration in human alters the blood concentration of phenylalanine, tyrosine, glutamate and lysine. Further confirmatory studies are required to understand how these metabolites related to the drug mechanism and also drug response, and to develop the biomarkers for predicting metformin response in humans.
Bulimia psychiczna – rozpowszechnienie, objawy i leczenie z uwzględnieniem aspektu stomatologicznego

Agata Osińska1, Marta Mozol-Jursza1, Marta Tyszkiewicz-Nwafor1, Agnieszka Słopień1, Elżbieta Paszyńska2 © Pediatr Med Rodz 2016, 12 (3), p. 276–284 © Medical Communications Sp. z o.o. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (CC BY-NC-ND). Reproduction is permitted for personal, educational, non-commercial use, provided that the original article is in whole, unmodified, and properly cited. DOI: 10.15557/PiMR.2016. 0028 Received: 10.11. 2015 Accepted: 17.03. 2016 Published: 30.09. 2016 Bulimia psychiczna – rozpowszechnienie, objawy i leczenie z uwzględnieniem aspektu stomatologicznego Bulimia nervosa – its prevalence, symptoms and treatment with special attention to oral health
Employees’ Physical Exercise, Resources, Engagement, and Performance: A Cross-sectional Study from HERO Model

The purpose of this study is to analyze the mediating role of work engagement in the relationship between resources and performance, and the invariance of the HEalthy & Resilient Organizations model (HERO) depending on physical exercise. Moreover, the study examines whether there are differences in the perception of these variables based on workout and gender. The sample consisted of 319 employees (156 sedentary and 163 non-sedentary employees). The results show that engagement mediates between resources and performance in both groups, which demonstrates the invariance of the model. Additionally, the findings revealed that, generally speaking, non-sedentary people are more empathetic and more absorbed in their job tasks and, specifically, that non-sedentary men are more empathetic and more vigorous at work than sedentary men. No differences were found between sedentary and non-sedentary women. Finally, regarding gender differences in variables, women are more empathetic and have better performance than men.
A single-arm phase II study of afatinib treatment for advanced EGFR-mutant non-small cell lung cancer (mNSCLC) patients (pts) with EGFR-tyrosine kinase inhibitor (TKI) resistance.

e19031 Background: mNSCLC pts benefit from EGFR TKI treatment. However, resistance inevitably occurs and is difficult to treat. We wanted to evaluate the efficacy of an ErbB-family inhibitor, afatinib, for patients with EGFR TKI resistance. Methods: Advanced mNSCLC pts or NSCLC pts with 6 months or longer benefit from EGFR TKI that failed on EGFR TKI as well as on chemotherapy were eligible. Afatinib was started at a dose determined by patients’ performance status, body mass index (BMI) and estimated glomerular filtration rate (eGFR). Primary endpoint was progression free survival (PFS), secondary endpoint was overall survival (OS). Data was analyzed for potential prognostic factors. Results: A total of 41 patients were recruited to this study since January 2013 till closure of recruitment at the end of June 2014. 29% were with performance status (PS) of 3-4, 68% with eGFR ≤ 80 cc/h, 15% with BMI of ≤ 20 kg/m2, 76% with prior treatment lines ≥ 2. At a median follow up of 7.9 months, median PFS was 2.9 mon.
Community Natural Forest Resource Dependency and its Degradation in Dembiya Woreda, Amhara National Regional State, Ethiopia

Even though forests are among the precious natural resources of the world, they are degraded from time to time at an alarming rate in many countries, including Ethiopia. Thus, this study was intended to explore community natural forest resource dependency and its causes of degradation in Dembiya woreda, using questionnaire, key informant interview, focus group discussion and analyzed using SPSS software. It was obtained as agriculture was the life of the sample household heads in the study kebeles and most others were engaged in selling of forest products (i.e., fuel wood and charcoal) so as to earn income for their livelihood. Some of the survey respondents didn’t rely on the forest resource in the area. The forest resources that are close to settlements are usually more degraded than those far away. Respondents replied that Dembiya woreda natural forest is the main source of fodder for rearing animals. Even their relationship and dependency on community forestry has been largely determined by the size and number of their livestock holdings. Many of the respondents argue as there was forest cover loss in the study area. The survey results also showed that the respondents identified decline of forest products, disappearance of wild animals and soil erosion respectively as sign of forest destruction in the study area. In line with this, many of the respondents agreed that fire wood collection was the major cause of forest degradation in the study area. On the other hand, the respondents identified expansion of agricultural land and population growth, demand for charcoal making, livestock raring, lack of community awareness, inadequate forest legislation, cutting trees for house construction and unintentional bush firing were the causes of forest degradation respectively.
Hamiltonian Perturbation Theory on a Poisson Algebra. Application to a Throbbing Top and to Magnetically Confined Particles

The Hamiltonian formulation of classical mechanics reveals an underlying Lie algebraic structure which is a key element for developing an efficient perturbation theory. But Lie structures are met in a wider class of dynamical systems, called Poisson systems; some examples are, among others, fluid dynamics, electrodynamics, kinetic theory. In the first part of this thesis, we propose a purely algebraic approach to classical perturbation theory to extend its scope to any Poisson system. In this method, introduced in [Vittot, 2004], a (Lie) transform allows to split the perturbation into a term preserving the unperturbed flow, and a smaller correction, quadratic in the original perturbation strength. The second part of the dissertation is about the dynamics of a Throbbing Top (a non-autonomous Rigid Body). Being probably the most basic example of Poisson system, the Top was a natural choice for an application of our theory. We consider first a symmetric Top with periodically dependent momenta of inertia; by introducing a suitable set of coordinates, the system is reduced to a nearly classical description; indeed we show that our theorem applies and reproduce the KAM theorem of classical mechanics. Then we switch to a non symmetric Top with non-periodically fluctuating momenta of inertia: in this case we study for which conditions the static trajectories give a good approximation to those of the non-autonomous system. In the third part of this work we study the dynamics of a magnetically confined particle. In this case the unperturbed flow is the dynamics in an arbitrary given electromagnetic field; then by perturbation theory one may reduce the dimensionality of the dynamics, or study the retroaction of the particle on the field. However, providing an efficient description of the unperturbed flow is a formidable task, related to the long-standing issue of Guiding Centre Theory in plasma physics. Recently a novel relativistic and non-perturbative approach to Guiding Centre theory has been proposed [Di Troia, 2018]. We derive the equations of motion and their Poisson structure in this description.