Miracle-dz/UniFAR-FTUs huggingface dataset:
Ferromagnetism in the upper branch of the Feshbach resonance and the hard-sphere Fermi gas

We address the question of ferromagnetism in repulsive Fermi gas, a problem of fundamental interest, using quantum Monte Carlo simulations that include backflow corrections. We investigate a two-component Fermi gas on the upper branch of a Feshbach resonance and contrast it with the hard-sphere gas. We find that, in both cases, the Fermi liquid becomes unstable to ferromagnetism at a kFa smaller than the mean field result, where kF is the Fermi wavevector and a is the scattering length. Even though the total energies E(kFa) are similar in the two cases, their pair correlations and kinetic energies are completely different, reflecting the underlying potentials. We discuss the extent to which our calculations shed light on recent experiments.
Evidence for a Saturated Spectrum of Atmospheric Gravity Waves.

Abstract The slope and power spectral density of atmospheric velocity fluctuations versus vertical wavenumber at large wavenumber are observed to be nearly independent of altitude. We suggest that such a universality is due to saturation of short vertical-scale fluctuations. A brief review of linear gravity wave saturation theory indicates a physical basis for such spectra. It is demonstrated that observed saturation spectra are not solely due to individually saturated waves but most likely result from amplitude limiting instabilities arising from wave superposition. We also show that while the spectrum is saturated at large wavenumbers, the total kinetic energy per unit mass and the characteristic vertical wavelength increase with altitude. Both of these predictions are consistent with observations.
Long-Term Changes in the Size of Pituitary Microadenomas

BACKGROUND The estimated prevalence of pituitary lesions is 10% to 38.5% in radiologic studies. However, how frequently these incidental lesions should be monitored by serial pituitary magnetic resonance imaging (MRI) remains unclear. OBJECTIVE To evaluate changes in pituitary microadenomas over time. DESIGN Retrospective, longitudinal cohort study. SETTING Mass General Brigham, Boston, Massachusetts. PATIENTS Evidence of pituitary microadenoma from MRI. MEASUREMENTS Dimensions of pituitary microadenomas. RESULTS During the study period (from 2003 to 2021), 414 patients with pituitary microadenomas were identified. Of the 177 patients who had more than 1 MRI, 78 had no change in the size of the microadenoma over time, 49 had an increase in size, 34 had a decrease in size, and 16 had both an increase and decrease in size. By linear mixed model analysis, the estimated slope was 0.016 mm/y (95% CI, -0.037 to 0.069). In the subgroup analysis, pituitary adenomas with a baseline size of 4 mm or less tended to increase in size. The estimated slope was 0.09 mm/y (CI, 0.020 to 0.161). In contrast, in the subgroup with baseline tumor size greater than 4 mm, the size tended to decrease. The estimated slope was -0.063 mm/y (CI, -0.141 to 0.015). LIMITATION Retrospective cohort, some patients were lost to follow-up for unknown reasons, and data were limited to local large institutions. CONCLUSION During the study period, approximately two thirds of the microadenomas remained unchanged or decreased in size. The growth, if any, was slow. These findings suggest that less frequent pituitary MRI surveillance for patients with incidental pituitary microadenomas may be safe. PRIMARY FUNDING SOURCE None.
The impact of lidocaine plaster prescribing reduction strategies: A comparison of two national health services in Europe

In 2017, two distinct interventions were implemented in Ireland and England to reduce prescribing of lidocaine medicated plasters. In Ireland, restrictions on reimbursement were introduced through implementation of an application system for reimbursement. In England, updated guidance on items which should not be routinely prescribed in primary care, including lidocaine plasters, was published. This study aims to compare how the interventions impacted prescribing of lidocaine plasters in these countries.
An Indonesian Adaption of Visual Aesthetics of Website Inventory (VisAWI) Questionnaire for Evaluating Video Game User Interface

Pixel art is one type of stylized style of the game’s visual appearances. Despite its gaining popularity, only a few studies have worked on analyzing the visual aesthetics of pixel art. While existing questionnaires were frequently used to measure user perceptions toward media products, unfortunately, they do not specifically design to measure visual aesthetics. Therefore, the study adapts the Visual Aesthetics of Website Inventory (VisAWI) designed by Moshagen and Tielsch (2010) to measure how users perceived the graphical interface aesthetics. We perform language adaptation with a cross-cultural adaptation approach to fit the target respondents, i.e., Indonesian, and the context of video games. The adaptation covers the translation process as well as language and culture adjustment for both languages. It consists of forward translation, synthesis, back translation, expert committee review, and pre-testing. Based on the validity and reliability tests, the results show that it is valid and reliable to use.
Parallel Programming in Finite Difference Method to Solve Turing's Model of Spot Pattern

Turing's model is a model contains reaction-diffusion equation that capable to form skin patterns on an animal. In this paper, Turing's model was investigated, with the model improvisation by Barrio et al. [12], in parallel programming to shown its speed up impact. The parallel programming managed to speed up the process up to 8.9 times while retaining the quality of the result, compared to traditional programming.
On propagation of plane fronts of normal zone within superconducting winding of magnet

Normal zone propagation within superconducting winding is studied theoretically in the model of discrete structure with alternating layers of superconductor and insulation. The exact solutions for longitudinal and transverse propagation, in steady regime, are obtained under assumptions that material parameters do not depend on temperature. For low current density j the general expressions for longitudinal v/sub /spl par// and transverse v/sub /spl perp// velocities coincide with known result (v/sub /spl par//, v/sub /spl perp///spl sim/j) in continuum approximation. Noticeable deviations from this linear dependence occur at high enough current density (v/sub /spl perp///spl sim/j/sup 2/3/), when the heating time of metal is much less or of order of the time of transverse thermal diffusion through insulating layer. In dimensionless units, the dependencies v/sub /spl par//(j) and v/sub /spl perp//(j) are described by universal curves for a given ratio of specific heat of superconductor and insulation. >
A Novel Variant in the LIPA Gene Associated with Distinct Phenotype

Abstract Deficiency of lysosomal acid lipase (LAL-D) is caused by biallelic pathogenic variants in the LIPA gene. Spectrum of LAL-D ranges from early onset of hepatosplenomegaly and psychomotor regression (Wolman disease) to a more chronic course (cholesteryl ester storage disease - CESD). The diagnosis is based on lipid and biomarker profiles, specific liver histopathology, enzyme deficiency, and identification of causative genetic variants. Biomarker findings are a useful for diagnostics of LAL-D, including high plasma concentration of chitotriosidase as well as elevated oxysterols. Current treatment options include enzyme replacement therapy (sebelipase-alpha), statins, liver transplantation, and stem cell transplantation. We present two pairs of siblings from Serbia with a distinctive phenotype resembling LAL-D with a novel variant of unknown significance (VUS) detected in the LIPA gene and residual LAL activity. All patients presented with hepatosplenomegaly at early childhood. In siblings from family 1, compound heterozygosity for a pathogenic c.419G>A (p.Trp140Ter) variant and a novel VUS c.851C>T (p.Ser284Phe) was detected. Patients from family 2 were homozygous for c.851C>T VUS and both have typical histopathologic findings for LAL-D in the liver. Enzyme activity of LAL was tested in three patients and reported as sufficient, and therefore enzyme replacement therapy could not be approved. When confronted with a challenge of diagnosing an inherited metabolic disorder, several aspects are taken into consideration: clinical manifestations, specific biomarkers, enzyme assay results, and molecular genetic findings. This report brings cases to light which have a considerable discrepancy between those aspects, namely the preserved LAL enzyme activity in presence of clinical manifestations and rare variants in the LIPA gene.
Temperature and excitation density dependence of the photoluminescence from annealed InAs/GaAs quantum dots

Using rapid thermal annealing, we fabricated a series of InAs/GaAs quantum dot samples with ground-state emission ranging from 1.05 eV to 1.35 eV. This set of annealed samples, all having the same density, allows us to study the influence of the barrier height on the temperature dependence of the photoluminescence (PL). The integrated PL follows an Arrhenius-type behavior, with activation energies matching the barrier heights. However, the quenching occurs at lower temperatures as the barrier height decreases. The modeling of these data enables us to understand the important mechanisms determining the critical temperature where the quenching occurs. We also present a detailed investigation into the excitation density dependence of the photoluminescence at different temperatures. Under relatively low excitation, this dependence is linear at 10 K, and becomes increasingly superlinear and eventually quadratic as the temperature is increased and carriers escape from the dots. However, under high excitation, the dependence remains linear even at high temperatures and the activation energy for quenching is different. We show that all these results can be understood by considering the independent capture and escape of electrons and holes in the dots.
Numerical analysis of a nonlinear double disc rotor-seal system

Based on the finite element method (FEM) and the Lagrange equation, a novel nonlinear model of a double disc rotor-seal system, including the coupled effects of the gravity force of the discs, Muszynska’s nonlinear seal fluid dynamic force, and the mass eccentricity of the discs, is proposed. The fourth order Runge-Kutta method is applied to solve the motion equations of the system and numerically determine the vibration response of the center of the discs. The dynamic behavior of the system is analyzed using bifurcation diagrams, time-history diagrams, axis orbit diagrams, Poincaré maps, and amplitude spectrums. With the rotor speed increasing, the system presents rich forms including periodic, multi-periodic, quasi-periodic, and chaotic motion. We also discuss the effects of the distance between the two discs, the mass of the discs, seal clearance, seal length, and seal drop pressure on the dynamic behavior of the system. The numerical results demonstrate that a symmetrical disc structure, small disc mass, proper seal clearance, long seal length and high seal drop pressure can enhance the stability of a double disc rotor-seal system. The results provide a theoretical foundation for the design of multi-stage sealing systems.
APOE4 Status and Cognitive Function in Middle-aged and Elderly People

Abstract Introduction APOE is one of the prominent genes involved in the increased risk of developing Alzheimer’s disease, but its effect on cognition in patients who are not yet diagnosed with dementia or mild cognitive impairment is relatively understudied. We aimed to examine the effect of ApoE4 on cognitive performance in unimpaired middle-aged and elderly persons. Materials and methods Our study included 51 cognitively unimpaired participants divided into ApoE4 positive patients and controls by APOE genotyping. The following clinical and demographic characteristics were collected: age, gender, education, social status, BMI, history of medical or psychiatric disorders. Patients with current anxiety or depressive disorders were excluded. Cognitive function was evaluated using MMSE, Rey Auditory-Verbal Learning Test, Rey Complex Figure test, TMT A and B and verbal fluency test. The two groups were matched for age, sex, and education. Categorial data was analyzed using Chi-Square and continuous data using Student-T test (parametric variables) or Mann-Whitney test (non-parametric variables). Statistical significance was considered at p≤. 05. Results There were 11 (21.6%) ApoE4 positive patients and 40 (78.4%) controls. There were no significant differences between the groups regarding socio-demographic and clinical characteristics. The ApoE4 positive group performed slightly worse on cognitive evaluations compared to controls but only the mean scores of the Rey Complex Figure Test – Memory reached statistical significance (p=.019). Conclusion Cognitive evaluation generally rendered lower scores in the ApoE4 group compared to the control group. However, only visual memory impairment scores were significantly lower in the ApoE4 positive individuals than in controls.
In Vivo Recovery of Factor VIII Following Transfusion: A Survey of Recent Data and Publications to Assess the Influence of Standards Used for Potency Assignment

Summary In the therapy of factor VIII deficiency, experience has taught the value of achieving a target level of plasma coagulation factor VIII. There is a consensus that an empirical value of 2 iu/dl/iu/kg may be used to estimate recovery, and hence plasma levels, of factor VIII. This may be influenced by the methods used to assign label potency to the products and for assessment of patient post-infusion plasmas. To assess a possible influence of the standard used to assign product potency on in vivo recovery, a survey was undertaken of recent in vivo recovery studies. Analysis of submitted data, in combination with published studies over the last ten years, revealed a significant influence of the standard used to assign potency to products on the measured in vivo recovery. Furthermore, from limited data the potency determined in post-infusion patient plasmas was found not to be influenced by the use of one-stage or chromogenic assay methods.
Protocol for the development of clinical guidelines for the management of chronic primary pain

© Author(s) (or their employer(s)) 2023. Reuse permitted under CC BYNC. No commercial reuse. See rights and permissions. Published by BMJ. InTroduCTIon Pain is an unpleasant sensory and emotional experience associated with actual or potential tissue damage. In 2018, the World Health Organization (WHO) revised the International Classification of Diseases, 11th Revision (ICD11) to include chronic pain as an independent disease for the first time (MG30.0). At the same time, the ICD11 also developed new classifications for chronic pain, including chronic primary pain (CPP), chronic cancerrelated pain, chronic postsurgical or posttraumatic pain, chronic secondary musculoskeletal pain, chronic secondary visceral pain, chronic neuropathic pain and chronic secondary headache or orofacial pain. Among these pain variants, the prevalence of CPP is high, and the course of the disease is prolonged, seriously influencing the life and social function of individuals suffering from it. Most of the current pain guidelines address only cancer pain. The National Institute for Health and Clinical Excellence does offer guidelines for chronic pain as a whole, including primary and secondary pain. But the ICD11 separates primary and secondary chronic pain as independent units,which indicates the necessity of developing different treatment for these two types of chronic pain.Thus, clear clinical practice guidelines for the treatment and management of CPP are lacking. Under the cooperation of the Drug Dependence Group, the psychiatry branch of the Chinese Psychiatrist Association, the pain branch of the Chinese Medical Doctors Association, the mental health branch of the China Narcotics Association and the psychiatry branch of the Shanghai Medical Association, experts from psychiatry, neurology, neurosurgery, pain medicine, anaesthesiology, evidencebased medicine, economics and other disciplines plan to summarise evidencebased recommendations on the treatment and management of CPP and construct clinical management guidelines for clinical decisionmaking. Extensive research has emphasised the importance of guideline protocols. Rigorous protocols can ensure an efficient, smooth guideline development process and guarantee the duties and responsibilities of the working group members. 5 This protocol aims to provide clear guidance for the development of the CPP guidelines and improve transparency. We summarise here the process of recruiting working group members, the collection and selection of clinical problems, the review of published data, and the formation of recommendations. In addition, we add information regarding the external review, publication, dissemination and implementation of these guidelines.
Closing the Gap between Hospitality Industry and Academia Research Agendas: An Exploratory Analysis Case Study

ABSTRACT The research needs, timelines, and priority gaps between the hospitality industry and academia are well documented in the literature, with limited actions taken by either side to bridge this research disparity. By exploratory analysis, we used the novel approach of organizing an academic seminar with research presentations, hosted for approximately 80 senior industry executives – to firstly demonstrate academic research relevance to industry, and secondly to survey attendees on how to create greater academic and industry research collaboration. The findings confirmed a lack of research cooperation and contrasting research agendas, reinforcing previous literature of industry requiring research that was timely, confidential, easy-to-read, and practical – all of which could run contrary to academia research priorities. Importantly, the industry practitioners expressed a wish to engage and work on research with Macao’s hospitality academics. This exploratory analysis is a first in the literature to use a real-life seminar to present hospitality academic research to industry, and act as a stimulus for future research communication and collaboration between academia and industry.
Biophilic cities and health

Biophilic design emerged at the beginning of the twenty-first century as an integral part of restorative environmental design, an approach that seeks to reestablish positive connections between nature and humanity in the built environment by minimizing damage to natural systems and human health (low environmental impact design), and by fostering positive experiences of nature in order to enrich the human mind, body and spirit (biophilic design) (Kellert 2005). Biophilic design is based on the theory that humans have an innate biological affinity for the natural environment (the biophilia hypothesis – Wilson 1984, 1993), and is informed by research on the restorative benefits of nature and psychoevolutionary theories of landscape preference. Kellert identified two basic dimensions of biophilic design: organic (or naturalistic) design involves the use of shapes and forms in buildings and landscapes that directly, indirectly, or symbolically elicit people’s inherent affinity for the natural environment, while vernacular (or place-based) design refers to buildings and landscapes that foster an attachment to place by connecting culture, history, and ecology within a geographic context (Kellert 2005, p. 5). Various frameworks have been developed in order to assist designers with the process of translating biophilia into the built environment by creating spaces that provide a connection to nature in order to enhance mental health and well-being (e.g. Kellert 2008, Browning et al. 2014, Kellert and Calabrese 2015). The frameworks are conceived as tools for understanding design opportunities at the building scale, by incorporating nature (e.g. plants, water) in the design of a space, using design features that evoke some aspects of nature – such as ornamentation, use of natural materials, and biomorphic forms – and using spatial configurations characteristic of the natural environment. The frameworks have been widely used to investigate biophilic design in a variety of different settings, including hospitals (Abdelaal and Soebarto 2019), dementia care homes (Peters and Verderber 2021), childcare facilities (Park and Lee 2019), primary schools (Ghaziani et al. 2021) and universities (Peters and D’Penna 2020), and have recently been incorporated in some of the main green building rating systems – such as LEED, LBC and WELL – as criteria for assessing the positive effect of building design on the health and well-being of the occupants.
A Perspective on the Use of FVIII Concentrates and Cryoprecipitate Prophylactically in Surgery or Therapeutically in Severe Bleeds in Patients with von Willebrand Disease Unresponsive to DDAVP: Results of an International Survey

Summary An international registry was established by the Subcommittee on von Willebrand Factor of the SSC/ISTH on the treatment of patients with types of von Willebrand disease (vWd) unresponsive to DDAVP infusion. Data was collected on 76 surgical events in 64 patients from 19 treatment centers. Thirty-three non-mucosal, 12 mucosal, 10 orthopedic and 21 dental procedures were reported. In the 76 surgical events, 14 cases prophylactically received cryoprecipitate while 62 received factor VIII (FVIII) concentrate. Surgical hemostasis was reported as satisfactory, good, or excellent in 75 of the 76 cases. Post-infusion bleeding times were measured in only three of 14 surgical events treated with cryoprecipitate. All three cases had a reduction but not correction of the bleeding time. The post-infusion bleeding time was measured in 27 of 62 cases in which FVIII concentrates were used. The bleeding time was normalized in 15, reduced but not normalized in eight, and not changed from baseline in four. Data was also collected from 16 treatment centers on 50 serious bleeding events in 35 patients. These included 19 gastrointestinal, 15 other mucosal, four central nervous system, seven orthopedic, and five other bleeds. Eleven cases received cryoprecipitate and 39 received FVIII concentrate as primary therapy. The efficacy of treatment was considered good or excellent in 49 of 50 cases. Post-infusion bleeding times were measured in only 15 of the 50 reported bleeding events. The post-infusion bleeding time was normalized in six, decreased but not normalized in eight, and not changed from baseline in one. In this retrospective survey, FVIII concentrates were subjectively as efficacious as cryoprecipitate in both the surgical setting and for the treatment of severe bleeds in patients with types of vWd unresponsive to DDAVP. Since the bleeding time was monitored during therapy in only a minority of these cases, a definitive relationship between the efficacy of therapy and normalization or reduction of the bleeding time in these two clinical settings cannot be established from this study. A prospective study on the use of FVIII and/or vWf concentrates in these clinical settings is necessary to address this issue.