Miracle-dz/UniFAR-FTUs huggingface dataset:
Gene by Extracellular Cyclic AMP

The signal transduction pathways that lead to gene induction are being intensively investigated in Dictyostelium discoideum. We have identified by deletion and transformation analysis a sequence element necessary for induction of a gene coding for uridine diphosphoglucose pyrophosphorylase (UDPGP1) of D. discoideum in response to extracellular cyclic AMP (cAMP). This regulatory element is located 380 base pairs upstream of the transcription start site and contains a G+C-rich partially palindromic sequence. It is not required for transcription per se but is required for induction of the gene in response to the stimulus of extracellular cAMP. The cAMP response sequence is also required for induction of the gene during normal development. A second A+T-rich cis-acting region located immediately downstream of the cAMP response sequence appears to be essential for the basal level of expression of the UDPGP1 gene. The position of the cAMP response element coincides with a DNase I-hypersensitive site that is observed when the UDPGP1 gene is actively transcribed.
A study of the impact dynamics of loosely supported heat exchanger tubes

Etude theorique de l'usure d'un tube non ajuste au support: analyse dimensionnelle, modele physique, simulation numerique du comportement du tube, developpement d'une formule simple montrant l'influence du niveau d'excitation et de la clairance tube-support sur la reponse du tube
Laboratory Characterization of Reclaimed Asphalt Pavement for Road Construction in Egypt

This paper presents the engineering characteristics of reclaimed asphalt pavement (RAP), blended with virgin aggregate for unbound base and subbase layers. The proportions of RAP were 0%, 20%, 60%, 80%, and 100% by total mass of the blend. The experimental laboratory testing included index properties such as gradation, modified Proctor compaction, California Bearing Ratio, and hydraulic conductivity. Repeated load resilient modulus testing was conducted on the blends. The impact of load duration on resilient modulus was also investigated. A strong inverse trend was found between resilient modulus and California Bearing Ratio. An accurate model was proposed for the prediction of the resilient modulus as a function of stress state and reclaimed asphalt pavement percentage with coefficient of determination of 0.94. Finally, multilayer elastic analysis of typical pavement sections with the base layer constructed of virgin aggregate and reclaimed asphalt pavement blends showed good performance.
A case report on phenobarbitone induced stevens-johnson syndrome: an alarming hypersensitivity reaction

Stevens-Johnson syndrome (SJS) is an Ig E mediated hyper sensitivity reaction, sometimes complicated by ocular manifestations. Antiepileptics induced SJS is common with carbamazepine. Phenobarbitone is known to cause hypersensitivity reactions like mild to moderate rashes but not life-threatening reactions like SJS. We present a case report of an 18 years old female patient who presented with chief complaints of multiple, fluid-filled lesions associated with itching all over the body for 20 days and inability to open her eyes for 18 days. It had developed following ingestion of Tab. Phenobarbitone 30 mg orally BD for 15 days. She was diagnosed as a case of SJS and treated with parenteral followed by oral corticosteroids and antihistaminics and recovered over a span of 20 days. Causality was assessed as per WHO-UMC Causality Assessment criteria and Naranjo Scale. Main pathogenesis is apoptosis through an interaction between cell-surface death receptor like Fas and its receptive ligand or due to genetic deficiency. In case of aromatic anticonvulsants, cross reactivity is also suspected. Genetic studies and cross reactivity testing can help prevent further incidences in few. Key-words: Apoptosis, Causality Assessment, Corticosteroids, Phenobarbitone, Stevens-Johnson Syndrome .
Fatty acid composition and total lipid content of the seed oil of Leucaena leucocephala

The common name for L. leucocephala are Lamtoro or Petai Cina (Indonesian), White lead tree (English) is one of the fastest growing leguminous trees in semi arid area. It is planted as a shade tree for cash crops, soil fertility improvement and a variety of other purposes. The seed oil of L. leucocephala (Lam) de Wit was investigated for its fatty acid composition and total lipid content. The main aims of the work were to determine the total lipid content and the fatty acid composition of L. leucocephala. The oil was obtained by n-hexane soxhlet extraction from the pulverized dried seeds of L. leucocephala, followed by the separation process of the oil by using silica gel column chromatography with different solvents then classified into different lipid classes (neutral lipids /NL, glycolipids/GL, and phospholipids/PL). The result showed that linoleic acid and ricinoleic acid dominated NL and GL whereas palmitic acid dominated in PL. NL, GL and PL fractions content unsaturated fatty acid 86.81%, 89.34% and 34.75% respectively. PL fraction was dominated by saturated fatty acid (65.25%).
Transmission expansion planning using nonlinear programming

A modified formulation of the transmission expansion planning (TEP) problem is proposed by revising the objective function and operating constraints to include the corona power loss term. Consequently, the objective function includes the cost of investment of transmission lines, the ohmic power loss as well as the corona power loss, which reveals a highly nonlinear objective function. Hence, the nonlinear programming or the non-convex optimization techniques are utilized to solve such large-scale practical problems. The new formulation has been applied to the well-known Garver's 6-bus system. It has been found that for a range of tariffs of kWh, the total cost of the expanded network (when including the corona power loss) is less than that when excluding this new term. Comparison with previously reported work is also included.
BEHAVIOR PROBLEMS AND PROSOCIAL RESOURCaE IN THE EVALUATION OF MOTHER AND TEACHERS

Children’s behavior problems can be internalizing or externalizing, with the latter being most commonly mentioned by parents and teachers as a nuisance factor. The aim is to compare assessments on indicators of behavior problems and prosocial resources in schoolchildren, based on the report of mothers and teachers, considering sex and level of school education as variables. In the present study, 100 teachers, 200 students and 200 mothers participated. For data collection, a characterization questionnaire and the Strengths and Difficulties Questionnaire - (SDQ) were used. Mothers and teachers found significant statistical differences in the assessment of prosocial resources and behavior problems in all scales and in the total SDQ score. Mothers surpassed teachers in the identification of problems for boys, of more prosocial resources for girls, and of more emotional symptoms in the early years of schooling. The simultaneous assessment of prosocial resources and problems leads to preventive practices. un cuestionario de caracterización y el Cuestionario de Capacidades y Dificultades – (SDQ). Se evidenció diferencias estadísticas significativas en la evaluación de los recursos adaptativos y problemas de comportamiento, por madres y profesoras, en todas las escalas y escore total del SDQ. Las madres identificaron más problemas que las profesoras, para los niños, más recursos de socialización para niñas, y más síntomas emocionales en los curos iniciales de escolarización. La evaluación simultánea de recursos adaptativos y problemas favorece prácticas preventivas.
Instructional design models—framework for innovative teaching and learning methodologies

Effective instructional design is essential for efficient teaching and learning outcomes in all disciplines, particularly in the nursing content-laden curriculum. Instructional design model steps and processes enable faculty to determine the scope of the course contents, sequence of instructions, innovative presentation, and evaluation strategies. The generic instructional model of analysis, design, development, implementation, and evaluation (ADDIE) underlies every instructional design process. This paper compares and contrasts the characteristic features, processes, and steps involved in the design of the Dick and Carey instructional design model with the Morrison, Ross and Kemp model using the underlying framework of ADDIE. Each model, with varying degrees of ease of use, employs a nine-step system and procedural processes to provide strategies for creating course instructions. Learner perspective is the focus of each model and the models both have an appeal to course design and specific learning activities within a course. While the Dick and Carey model requires the use of all the components in order to create an instruction, the Morrison, Ross and Kemp model, with its independent or simultaneous use of the elements in any order, and the knowledge that there are cases where not all the nine elements are applied, make the model more flexible and easier to use. Integration of the elements of the Morrison, Ross and Kemp model into the blood transfusion learning activity for the learners in a medical-surgical nursing course validates the model and demonstrates its effective application to real-world instructional design process. I declare that this paper is my own original work and has not been published elsewhere.
An Examination of the Implementation Fidelity of the Risk, Need, Responsivity Model of Rehabilitation in Ontario’s Direct Operated Youth Justice Facilities by Lori Walls A thesis submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy

Youth Justice Services in Ontario, Canada utilizes the Risk Need Responsivity Model of Rehabilitation (RNR model) as the evidence supporting their case management practices. The use of the RNR model has been substantiated through research that has suggested that when all components of the model are adhered to significant reductions in recidivism are possible. Since achieving reductions in recidivism is a primary goal of Ontario’s youth justice systems, fidelity to the RNR model is essential to assist in reaching the desired outcomes. The aim of this research project was to test fidelity to the RNR model in the direct operated youth justice system in Ontario, as well as to examine the contention that the principle of responsivity is the least understood and therefore least utilized component of the model. A retrospective chart review design that examined the files of all male youth meeting the study criteria between the fiscal years of 2001 and 2014 in the direct operated facilities was used to address three research questions. The first research question sought to understand what information was collected in the case management process that aligned with the model components. The second question examined how the information collected was applied to case management goals for youth. The third question compared the identification and utilization of RNR information between the case management plans created in the community with those created in the direct operated facilities. The key findings from this study suggest that fidelity to the RNR model can be achieved in respect to the identification of information that aligns with each of the model components. However, operationalization of the information into case management goals has proven to be less successful. Study results indicate that neither identification nor utilization of responsivity factors in case management plans is occurring in either the community or the facility setting.
Effect of Nutritional Composition of Diets on Chemical Components of Red Sea Bream Broodstock and Eggs Produced*1

A study was conducted to obtain some basic data necessary for biochemical evaluation of egg quality by investigating a relationship between composition of diets for broodstock and chemical components of eggs produced. Both broodstock and eggs produced by broodstock, which had been fed on various diets with different nutritional quality for more than 5 months, were analysed for fatty acids, minerals, and proximate composition. There was no marked difference in proximate composition due to the difference of the nutritional quality of diets in both male and female muscles and livers except for the male broodstock fed on either the low-protein or the EFA-deficient diet where the protein content decreased and the lipid content increased. The protein and lipid contents were higher and the water content was lower in the ovary from broodstock given the cuttlefish meal diet. Mineral composition in both broodstock tissues and eggs showed no difference, in general, even in the phosphorus content of vertebrae and eggs from the broodstock given the phosphorus-deficient diet. In the eggs produduced by the broodstock fed on the low-protein diet a slightly high moisture content and a low
Measurements and Numerical Modelling of High Rise Building Foundations on Frankfurt Clay

Many high rise buildings were founded on Frankfurt clay on rafts applying average contact stresses in the order of 0.4 MPa. Beside rafts now piled-rafts are often used to reduce total and differential settlements. An extensive research program was conducted to measure the foundation behaviour. Numerical models were developed to simulate the raft and piled raft behaviour. Comparisons between measurements and numerical results are presented.
Climate for Computer-Mediated Communication Technology Implementation and Implementation Success

MEYER, DAVID CHARLES. Climate for Computer-Mediated Communication Technology Implementation and Implementation Success. Electronic mail and the world-wide web may be particularly helpful to university faculty members as they implement these technologies into their teaching. However, effective implementation depends on a host of social, technical, and historical factors. This study creates and tests a "climate for computer-mediated communication technology implementation" survey. This quantitative climate measure correlates specific departmentlevel policies and practices with implementation success. The implementation climate at a large state university based on 420 faculty members representing 58 different academic departments suggests that a climate for computermediated communication (CMC) technology implementation does exist at the department level within the university. In addition, the climate for CMC technology implementation accounts for variance in implementation success over and above more traditional implementation correlates measured in prior MIS research (i.e., individual expectations, task urgency, technical expertise). The research results demonstrate the applicability of MIS research findings to educational settings and quantitatively confirm the existence of a department-level climate for implementation. ii BIOGRAPHY David Meyer studied history, English, and education at the University of Minnesota and received his bachelor’s degree (cum laude) in Secondary Education. His career path has included teaching secondary school, facilitating teamwork within management teams, organizing community service programs for at-risk youth, and coaching collegiate alpine ski racing. David’s career activities are dedicated to the belief that the solutions to complex social and business problems require interpersonal communication skills and team-based problem solving approaches. This applied experience coupled with an academic background in organizational psychology, management of information science, and research methods provides the foundation of this dissertation. iii ACKNOWLEDGEMENTS I am grateful for the financial support that I received from the Division of Undergraduate Affairs at North Carolina State University. This work also received partial support from the National Science Foundation’s Science and Technology Center (STC) under Agreement Number CHE-9876674. Any opinions, findings, conclusions, or recommendations expressed in this material are those of the author and do not necessarily reflect the views of the National Science Foundation. I owe my friends and faculty advisors at North Carolina State University, Duke University, and Boise State University many thanks for their guidance and support. I’m also grateful for all the good advice Dr. Denis Gray, my committee chair, has given me over the years. Research involves choices—it is good to have wise counsel. Watching someone write a dissertation may be more work than actually writing one. This dissertation is dedicated to my best friend, Jill Galanter. Thanks for being my biggest fan.
A New Concept of using Transverse Loading to Characterize Environmental Stress Cracking Resistance (ESCR) of Polyethylene (PE)

Environmental stress cracking (ESC) is a phenomenon that has seriously limited semi-crystalline polymers such as polyethylene (PE) for load-bearing applications [2]. PE is known for its excellent chemical resistance and reasonable mechanical strength, and is widely used in low-stress applications such as food containers, plastic pipes, and liner for steel pipes and tanks. Although PE has good chemical resistance, it suffers from cracking in an environment that contains soaps, wetting agents, oils, or detergents. As a result, ESC resistance (ESCR) is an important property for evaluating suitability of PE for load-bearing applications.
Subcutaneous (SC) absorption of biotherapeutics – knowns and unknowns

Subcutaneous (SC) administration of biotherapeutics offers several potential advantages compared to intravenous (IV) administration. Many biotherapeutics, both marketed or in development, are administered via the SC route. This minireview provides an overview on the presystemic absorption processes following SC administration, the resulting pharmacokinetics after SC administration and provides recent case examples on the development of SC administered drugs with a focus on monoclonal antibodies (mAbs). SC absorption of biotherapeutics is relatively slow and mostly incomplete. Knowledge on the SC tissue is important to understand the absorption kinetics after SC administration. Transport in the subcutis to the absorbing blood or lymph capillaries appears to be a major contributor to the slow SC absorption. Larger proteins (>20 kDa) are mostly absorbed via the lymphatic system, though potential species differences are not fully understood yet. Also the presystemic catabolism leading to incomplete bioavailability is little understood, both the involved enzymes and its translation across species. For IgGs, binding to neonatal Fc receptor (FcRn) is important to obtain a high bioavailability. Overall, several aspects of SC absorption are still poorly understood yet, which hampers e.g. translation across species. Further research in this area is warranted.
CUTANEOUS LEISHMANIASIS IN BASRAH VILLAGES, SOUTH IRAQ By HIND

597 CUTANEOUS LEISHMANIASIS IN BASRAH VILLAGES, SOUTH IRAQ By HIND MAHDI JARALLAH Marine Science Center, University of Basrah, Basrah, Iraq Abstract CL in Iraq is caused by both Leishmania major and Leishmania tropica. Marshes Villages of Basrah province south Iraq are regarded as a rural area. A total of 35 cutaneous leishmaniasis cases 12 (34.28%) females and 23(65.71%) males were clinically registered from April 2013 to March 2014 in Health Care Center of Basrah Marshes Villages, South of Iraq are reported and investigated. All patients were parasitologically confirmed by stained smears and culture, the main clinical features were ulcerations. Number of cutaneous lesions per patients ranged from 1 to 5 with different lesions’ size from 3×3 mm to 25×25 mm in diameter. Amastigotes form were detected in all cases 35 (100%), while promastigotes from were found in culture sample of 29 (82.8%) cases. The results were analyzed and evaluated. Cutaneous leishmaniasis in Basrah marshes villages may differ from other regions because of the difference of the Leishmania strains, people life style, behaviors and difference in vectors and reservoir hosts.
Exploring the experiences of tourists at heritage sites: the case of Liliesleaf Farm Museum and the Hector Pieterson Memorial & Museum

iii Acknowledgements . iv List of Figures . viii List of Tables. viii List of Acronyms . ix CHAPTER ONE – INTRODUCTION . 1 1.1 What is Heritage Tourism? 1 1.2 The Importance of Visiting Struggle Heritage Sites . 2 1.3 Study Rationale . 3 1.4 Research Structure. 4 1.5 Theoretical Framework . 4 CHAPTER TWO: INTERNATIONAL LITERATURE REVIEW ON HERITAGE TOURISM . 6 2.
Designing for Conversational System Trustworthiness: The Designing for Conversational System Trustworthiness: The Impact of Model Transparency on Trust and Task Performance Impact of Model Transparency on Trust and Task Performance

Designing for system trustworthiness promises to address challenges of opaqueness and uncertainty introduced through Machine Learning (ML)-based systems by allowing users to understand and interpret systems’ underlying working mechanisms. However, empirical exploration of trustworthiness measures and their effectiveness is scarce and inconclusive. We investigated how varying model confidence (70% versus 90%) and making confidence levels transparent to the user (explanatory statement versus no explanatory statement) may influence perceptions of trust and performance in an information retrieval task assisted by a conversational system. In a field experiment with 104 users, our findings indicate that neither model confidence nor transparency seem to impact trust in the conversational system. However, users’ task performance is positively influenced by both transparency and trust in the system. While this study considers the complex interplay of system trustworthiness, trust, and subsequent behavioral outcomes, our results call into question the relation between system trustworthiness and user trust.
In-beam γ -ray spectroscopy of 35 Mg via knockout reactions at intermediate energies

The isotope 35 Mg was spectroscopically studied via nucleon-removal reactions from 36 Mg and 37 Al secondary beams at intermediate energies. The experiment’s aim was to clarify the level structure of this nucleus located in between the N = 20 and 28 shell quenchings. De-excitation γ -ray energies, exclusive cross sections, and parallel momentum of outgoing 35 Mg for several ﬁnal states were measured and compared to structure calculations in the shell model and antisymmetrized molecular dynamics framework and the eikonal reaction calculation, further developing the level scheme of 35 Mg. It was found that a large fraction of the one-neutron knockout reaction goes into unbound states of 35 Mg, which may explain missing f -wave strength.