Miracle-dz/UniFAR-FTUs huggingface dataset:
CDIO Course Development for Faculty in Raw Materials Programmes

In Europe, the existing MSc programmes which are linked to the thematic Raw Material content often focus mainly on technical knowledge in itself, and students graduate as professionals who know how to solve pre-defined technical problems. Students in such programmes seldom practice entrepreneurial, communication and innovation skills at a level that is needed in working life. On the other hand, the CDIO Initiative has developed a framework for modernizing engineering education by introducing such skills and thinking into the technical programmes and courses. It is widely discussed in the CDIO community that one of the constraints in implementing CDIO is faculty staff professional development. CDIO standards 9 and 10 focus on the faculty development and competencies both in terms of pedagogic as well as learning methods to deal with personal and interpersonal skills, and product, process, and system building skills. In order to bring a change and implement CDIO into the Raw Materials programmes in Europe, a modular course for training in CDIO was developed and delivered for the faculty member in the Raw Materials sector. This paper accounts for the development of the faculty training course, and provides a unique perspective on the implementation of CDIO into raw materials related programmes capturing the different models of implementation from different universities’ programmes and courses. The various universities involved provide programmes and courses across the entire value chain of raw materials from mining and minerals processing to materials design, sustainability and recycling. This paper will serve as a reference for the educators to develop and implement CDIO education methods in specific disciplines as illustrated here in the field of raw materials related programmes.
OTT_A_235231 3867..3880

Department of Oncology, Luoyang Central Hospital Affiliated toZhengzhouUniversity, Luoyang, People’s Republic of China Purpose: Non-small cell lung cancer (NSCLC) is the largest type of lung cancer (LC) with a higher mortality rate. Circular RNAs (circRNAs) have been shown to play an important role in cancer progression. Therefore, this study was to explore the function of hsa_circ_0043265 in NSCLC. Methods: The expression levels of hsa_circ_0043265, microRNA-25-3p (miR-25-3p) and forkhead box P2 (FOXP2) were determined by quantitative real-time polymerase chain reaction (qRT-PCR). Ribonuclease R (RNase R) and Actinomycin D (ActD) were used to verify the authenticity and stability of hsa_circ_0043265. Cell counting kit-8 (CCK-8), flow cytometry and transwell assays were used to evaluate the abilities of proliferation, apoptosis, migration and invasion of NSCLC cells. Also, Western blot (WB) analysis was performed to assess the levels of apoptosis, epithelial–mesenchymal transition (EMT) and proliferationrelated proteins and FOXP2 protein. RNA immunoprecipitation (RIP) and dual-luciferase reporter assays were used to verify the interaction between miR-25-3p and hsa_circ_0043265 or FOXP2. Besides, mice xenograft models were constructed to confirm the effect of hsa_circ_0043265 on NSCLC tumor growth in vivo. Results: Hsa_circ_0043265 was lowly expressed in NSCLC tissues and cells, and its overexpression inhibited the proliferation, migration, invasion and EMT process, while improved the apoptosis of NSCLC cells. MiR-25-3p could be sponged by hsa_circ_0043265, and its overexpression could invert the suppression effect of overexpressed-hsa _circ_0043265 on NSCLC progression. Moreover, FOXP2 was a target of miR-25-3p, and its silencing also could reverse the inhibition effect of overexpressed-hsa_circ_0043265 on NSCLC progression. In addition, hsa_circ_0043265 overexpression reduced the tumor growth of NSCLC in vivo. Conclusion: Hsa_circ_0043265 could sponge miR-25-3p to improve FOXP2 expression, thereby inhibiting NSCLC progression. This study showed that hsa_circ_0043265 could be a potential biomarker for early diagnosis of NSCLC.
University of Birmingham Blockchain application in remote condition monitoring

—Through advanced sensor technologies, satellite-based authentication, and high bandwidth data networks, Remote Condition Monitoring (RCM) systems are now an essential ‘Internet of Things’ (IoT) resource for efﬁcient operation of railway infrastructure. However, the full potential of this big data has yet to be realized. Data is currently collected and used in siloes, with limited visibility of all possible datasets for exploitation. The RSSB on behalf of the UK Rail Industry established a cross-industry research program, T1010, to build stronger cooperation between stakeholders in sharing RCM data. This research builds upon T1010, to explore the use of blockchain and smart contracts to automate, in an auditable and tamper-proof way, the commercial agreements and payment processes for data trading. By removing the limitations of paper-based agreements, our goal is to enable innovation in shared business processes and an IoT data marketplace. Building on existing smart contract-based schemes for trading and sharing IoT data over blockchain networks, this research identiﬁes novel ways to enforce agreements and ensure fair cost attribution between parties, without a Trusted Third Party. The initial design of a blockchain-based framework is presented, oriented around the data provider, consumer, and smart contracts. Blockchain-hosted data access agreement and accounting models are speciﬁed in detail. The processors in the efﬁcient permissioned blockchain platforms Hyperledger Fabric, Sawtooth, and Iroha have been analyzed for their suitability for implementation. We then outline our future work to evaluate and validate two industrial use cases: monitoring systems for unattended overhead line equipment and axle bearings.
CMAR_A_262567 7813..7826

*These authors contributed equally to this work. Objective: The efficacy of surgery as the primary treatment modality for nasopharyngeal carcinoma (NPC) is yet to be clarified. Therefore, we aimed to explore the shortand longterm efficacy of surgery for early-stage NPC. Methods: We retrospectively evaluated 341 patients diagnosed with early-stage NPC between September 2010 and December 2015. Among them, 58 patients underwent endoscopic nasopharyngectomy combined with chemoradiotherapy, whereas 283 patients underwent conventional chemoradiotherapy. The patients who underwent concurrent chemoradiotherapy or radiotherapy alone were matched to patients who underwent surgery in a 1:2 ratio using propensity score matching to analyze the clinical efficacy of each therapeutic modality. The primary endpoint was survival, and the secondary endpoints were tumor regression rate and reduction in Epstein–Barr virus (EBV)-DNA levels. Results: After matching, 156 patients were enrolled (58 patients in the surgery group; 98 patients in the non-surgery group). The baseline data of the matched patients had good intergroup comparability (All P>0.05). The surgery group had significantly higher 5-year overall survival (98.30% vs. 91.70%), disease-free survival (98.30% vs. 81.40%), and recurrencefree survival (100.00% vs. 90.10%) rates than did the non-surgery group (All P<0.05). In total, 0 and 14 patients in the surgery and non-surgery groups, respectively, had residual cancer at the end of treatment (P=0.001). All patients in the surgery group tested negative for EBV-DNA, whereas two patients in the non-surgery group tested positive. The incidence of hematologic toxicity during treatment was similar between the two groups (All P>0.05). Still, the incidence of severe oral mucositis was lower in the surgery group than in the nonsurgery group (37.9% vs. 54.08%, P=0.051). Conclusion: Surgery can improve the clearance rate of EB virus and reduce tumor residue. Surgery may be a safe and effective treatment for early NPC.
Central Memory T Cells Extensive Replicative Capacity of Human

To characterize the replicative capacity of human central memory (T CM ) CD4 T cells, we have developed a deﬁned culture system optimized for the ex vivo expansion of Ag-speciﬁc CD4 (cid:1) T cells. Artiﬁcial APCs (aAPCs) consisting of magnetic beads coated with Abs to HLA class II and a costimulatory Ab to CD28 were prepared; peptide-charged HLA class II tetramers were then loaded on the beads to provide Ag speciﬁcity. Inﬂuenza-speciﬁc DR*0401 CD4 T CM were isolated from the peripheral blood of normal donors by ﬂow cytometry. Peptide-loaded aAPC were not sufﬁcient to induce resting CD4 T CM to proliferate. In contrast, we found that the beads efﬁciently promoted the growth of previously activated CD4 T CM cells, yielding cultures with > 80% Ag-speciﬁc CD4 cells after two stimulations. Further stimulation with peptide-loaded aAPC increased purity to > 99% Ag-speciﬁc T cells. After in vitro culture for 3–12 wk, the ﬂu-speciﬁc CD4 T CM had surface markers that were generally consistent with an effector phenotype described for CD8 T cells, except for the maintenance of CD28 expression. The T CM were capable of 20–40 mean population doublings in vitro, and the expanded cells produced IFN- (cid:2) , IL-2, and TNF- (cid:3) in response to Ag, and a subset of cells also secreted IL-4 with PMA/ionomycin treatment. In conclusion, aAPCs expand T CM that have extensive replicative capacity, and have potential applications in adoptive immunotherapy as well as for studying the biology of human MHC class II-restricted T cells. The Journal of Immunology, 2004, found of in
THE PHILOSOPHICAL FOUNDATION OF MAINSTREAM MACROECONOMICS

The purpose here is to explore the philosophy implicit in mainstream macroeconomics in terms of how real economic systems are understood and how knowledge about them is built and assessed. Mainstream macroeconomics has evolved in response to policy demands in the wake of the financial crisis. But this evolution has been constrained by the internal methodological requirements of its dominant theoretical approach which are often incompatible with the external requirements of evidence and policy application. The core theoretical approach has persisted, particularly with its emphasis on microfoundations. Yet the notion of internal consistency by which the microfoundations project is justified is challenged by a broader, philosophical, notion of consistency. The long-running expression of opposition in mainstream macroeconomics between logical coherence and empirical coherence (or between rigour and realism) accordingly requires examination at the philosophical level. The case is made on philosophical grounds for considering approaches to macroeconomics which avoid this kind of opposition.
Prevalence and Related Factors of Cyber Addiction among Moroccan University Students

Original Research Article Background: Internet addiction may be a major health problem among students. Indeed, its prevalence is higher than that found in the general population. Aim: to assess the prevalence of cyberaddiction as well as the factors associated with cyberaddiction in a sample of Moroccan university students. Methods: We used an online questionnaire including sociodemographic and clinical data, the Internet Addiction Test (IAT), the Rosenberg Self-Esteem Scale and the Hospital Anxiety and Depression Scale (HADS). Statistical analysis: IBM's Statistical Package for Social Sciences (SPSS) for Windows, version 26. Results: The current prevalence of cyberaddiction among students was 30.9%, with no significant difference according to gender. A younger age, long duration of internet use (p<0.001), activities of social media (p<0.01) and the video game (p<0.03) were the correlated with cyberaddiction. On the other hand, a significant association was found between internet addiction and high levels of depression and anxiety (p<0.001), as well as with low self-esteem (p<0.001). Furthermore, a statistically significant association was found between internet addiction and high levels of depression and anxiety (p<0.001), as well as with low self-esteem (p<0.001). Conclusion: The study suggests an association between young age, long duration of Internet use and the risk for developing cyberaddiction. Depressive and anxiety levels, low self-esteem, are also associated with cyberaddiction. The study suggests that considering the high prevalence of this kind of addiction, an awareness and prevention programme for cyberaddiction is needed among this student population.
NUMBER FIELDS WITH DISCRIMINANT ±2a3b AND GALOIS GROUP An OR Sn

The authors present three-point and four-point covers having bad reduction at 2 and 3 only, with Galois group An or Sn for n equal to 9, 10, 12, 18, 28, and 33. By specializing these covers, they obtain number fields ramified at 2 and 3 only, with Galois group An or Sn for n equal to 9, 10, 11, 12, 17, 18, 25, 28, 30, and 33.
Effect of symbiotic bee fungus on survival of stingless bee Heterotrigona itama larvae

Aims: Symbiotic bee fungus associated with the stingless bee larval food has been revealed to play a major role in performing a mutual relationship with the host. The fungus is believed capable to produce crucial nutrients that are required for larval pupation. However, detailed information on the fungus identification isolated from the larval food of our native Indo-Malaya stingless bee, Heterotrigona itama (Hymenoptera: Apidae), is poorly understood. Hence, this study was conducted to determine the effect of fungus isolated from the stingless bee larval food on the survival of H. itama larvae and identify the isolated fungus using both morphological and molecular analyses. Methodology and results: Elisa plates designed with F-bottom type were used as artificial brood cells in a controlled condition. The eggs transferred to Elisa plates were kept in the incubator with 75%-100% humidity and 25 ± 2.5 °C of temperature. This study carried out in three different treatments: (1) microbes-free larval food, (2) fresh larval food and (3) microbes-free larval food with fungus supplement. Results showed that the survival of H. itama larvae depends on the presence of beneficial fungus with the highest survival rate (Treatment 2 = 85.71%). The absence of the beneficial fungus in the fluid food of H. itama showed the lowest survival rate (Treatment 1 = 37.14%). Microscopy analysis showed that the fungus had various forms, including unconjugated asci, round-shaped ascospore and pseudohyphae. The molecular characterisation of the isolated fungi was performed using 23S rRNA gene sequencing using universal primers ITS1 and ITS4. DNA barcoding of three isolated fungi confirmed all isolated fungi matched Panus lecomtei (Basidiomycetes; Poriales; Polyporaceae) with 99.70% of similarity. Conclusion, significance and impact of study: This study provides information on the importance of whitish fungus in appearance that existed in the brood cell, which is proposed to be the crucial component of in-vitro stingless bee queen rearing protocol.
Shock vs. ice-water passive avoidance learning in wild and domestic <Emphasis Type="Italic">Rattus norvegicus </Emphasis>

Two experiments comparing passive avoidance responses of wild and domestic Norway rats included both shock and ice water as aversive stimuli. Experiment I indicated that wild rats did not exhibit passive avoidance in these situations and that shock was more effective than ice water as an aversive stimulus for domestic rats. Modifications of the ice-water apparatus in Experiment II resulted in improved passive responses in domestic rats, but ice water was still not as effective as shock. Wild rats again showed no passive avoidance. The results of these two experiments were interpreted in terms of stock differences in species-specific defense reactions for these avoidance situations.
THE CONTEMPORANEOUS EFFECT OF UNEMPLOYMENT ON CRIME RATES: THE CASE OF INDIANA

This paper examines the contemporaneous effect of unemployment on crime rates in the State of Indiana. This study uses a fixed-effect model and employs a balanced panel data of 23 sample counties in the State of Indiana from year 20062013. After controlling for population size and demographic, socioeconomic, and county-specific characteristics, results of this paper show that unemployment has a negative contemporaneous effect on violent crime rate and a null influence on property crime rate. This finding is consistent with the criminal opportunity effect of Cantor and Land (1985). Results of this paper also show that male and youth of age group 14-25 positively contribute to both violent crime and property crime in the State of Indiana. JEL Classification: J60, K42
The Short-Run Impacts of Immigration on Native Workers: Evidence from the US Construction Sector

This paper provides new empirical estimates of the short-run impacts of immigration on the employment opportunities of US-born workers. We focus on the constructor sector, a primary employer of immigrant workers in the US and one of the economic sectors with the highest share of immigrants, about 29% in 2016 according to the Bureau of Labor Statistics. Using panel data at the metropolitan area-year level of aggregation constructed from US Census and American Community Survey data, we find that a 10 percentage point increase in the share of immigrant workers reduces annual earnings of US-born construction workers by at least 3.7%, with workers in immigrant-prone trades experiencing earnings reductions in excess of 7.3%. These bounds are derived using a so-called “imperfect instrument approach” (Nevo and Rosen, 2012), whereby the share of immigrant workers is instrumented by the share of immigrants across all sectors of the economy. Our partial identification strategy relies on the assumptions that the share of immigrants across all economic sectors in a market is positively correlated with construction-specific labor demand shocks about location and year effects, but less so than the share of immigrants in construction. Our results further indicate that US-born workers experience lower annual wages through reduced employment (fewer weeks worked per year) rather than lower weekly wages. In immigrant-prone trades, the unemployment rate of natives is predicted to increase by at least 3.7 percentage points for each 10 percentage point increase in the immigrant share.
Mixed Evidence for Name Priming Effects as a Measure of Implicit Self-Esteem: A Conceptual Replication of Krause Et Al. (2012)

Krause et al. (2012) demonstrated that evaluative responses elicited by self-related primes in an affective priming task have incremental validity over explicit self-esteem in predicting self-serving biases in performance estimations and expectations in an anagram task. We conducted a conceptual replication of their experiment in which we added a behavioral and an affective outcome and presented names instead of faces as self-related primes. A heterogeneous sample (N = 96) was recruited for an online data collection. Name primes produced significantly positive and reliable priming effects, which correlated with explicit self-esteem. However, neither these priming effects nor explicit self-esteem predicted the cognitive, affective, or behavioral outcomes. Despite the lack of predictive validity of the implicit measure for affective and behavioral outcomes, the positive and reliable priming effects produced by name primes warrant the further investigation of the validity of the affective priming paradigm as a measure of implicit self-esteem.
TOPOGRAPHY AND VEGETATION COVER INFLUENCE ON URBAN HEAT ISLAND OF ZARAGOZA (SPAIN)

This work analyses the relationships between the spatial patterns of urban heat island and the distribution of topography and vegetation cover in Zaragoza (Northeast of Spain). Two independent variables were considered: Elevation, which was obtained from a Digital Elevation Model (DEM), and Normalized Difference Vegetation Index (NDVI), mapped from a Landsat ETM+ image. Different spatial analysis were applied using GIS. The results indicate a high spatial correlation between the general spatial patterns of urban heat island and elevation (r = -0.57), and temperature patterns and NDVI (r = -0.60), both statistically significant (p < 0.01). The percentage of thermal spatial variance explained by vegetation cover and elevation is very high (54 %), and although the prediction of temperature values is poor in some areas using these independent variables, the results of this work indicate that the physical and environmental attributes within the city can not be neglected in the explanation of the UHI in Zaragoza.
Young leaders and innovation: does SEW evolution across generations matter?

We suppose that the heterogeneous innovative behavior of family firms can be explained by a different salience of socio-emotional wealth factors (SEW), characterizing young family managers with respect to senior ones. Based on this argument, the paper investigates whether some SEW factors are conceived in a different manner by junior and senior generations within the same family firm; and whether such an eventual evolution is related to the firm’ s willingness to innovate. We carry out a quantitative study in a research setting in which the renewal of the leadership is in progress. Results show that some differences in SEW factors exist: young family leaders show a lower emotional attachment as well as a lower renewal of family bonds through generations. Moreover, these factors are related to the willingness to innovate. Lastly, senior generations, still co-involved in the management, exert a moderating action in a likely complex interplay.
Clay and Magnetic Sand Biomass Based Composite for Methylene Blue Adsorption (Effects of Composition Ratios of Functional Materials and Synthesis Conditions)

In recent times, iron oxide based magnetic nanoparticles (mainly magnetite (Fe3O4) or maghemite (γ-Fe2O3)) as well as clay and clay based composites, have become very important in the elimination of persistent organic compounds from waste water systems. This has been carried out by magnetic assisted chemical separation (MACS) process. The feasibility of using two locally sourced materials: magnetic black sand from down beach Limbe and clay from Bamessing Ndop for the removal of methylene blue (MB) dye from aqueous solution have been studied. The effects of contact time, pH, adsorbent dosage, temperature, grinding / length of grinding, composition ratios of the functional materials such as peel, pectin and starch, hydrothermal carbonization and concentration of dye solution were investigated. The test samples have exhibited great potentials for use in waste water purification for the removal of persistent organic compounds such as methylene blue dye. The results revealed that, varying various compositional ratios of the functional materials such as peel, pectin and starch to increase their affinity, selectivity, or degradation capacity towards targeted compounds influenced the activities of the adsorbents. The results also indicated that maximum performance was reached at pH value of 8 for Iron oxide (sand) based adsorbents and 12 for clay based adsorbents. Grinding / increase in grinding time have shown positive effects on the adsorbent properties of the composite from black sand and maximum grinding time varied depending on the compositional ratios of functional materials. Also within a certain threshold, hydrothermal carbonization improved on the adsorbent efficiency of the samples formulated with saccharides. The adsorption kinetic of methylene blue onto the adsorbents could be better fitted by the linear Langmuir isotherm and the pseudo-second-order model was a better model fitting the kinetics of the adsorption in this study.