Miracle-dz/UniFAR-FTUs huggingface dataset:
On graphite and the 2175 Å extinction profile

Classical electromagnetic theory is used to study the constraints placed on interstellar graphite grains by the observations of Fitzpatrick & Massa (who found large variations in FWHM γ of the bump with minimal, and uncorrelated, variations in the central wavelength λ 0 ). Accurate calculations using the discrete dipole approximation are used to test the accuracy of the commonly used 1/3-2/3 approximation for graphite spheres. We show that the 1/3-2/3 approximation is sufficiently accurate for use in studying variations in the extinction profile due to changes in graphite grain size or coatings on the grains. We investigate the effect on the 2175 A extinction profile of (1) changes in size distribution, (2) changes in grain shape, and (3) coatings of ice or other material
Hand Dexterity Is Associated with the Ability to Resolve Perceptual and Cognitive Interference in Older Adults: Pilot Study

The relationship between hand dexterity and inhibitory control across the lifespan is underexplored. In this pilot study, we examined inhibitory control using a modified Simon task. During the task, participants were presented with right- and left-pointing arrows located either on the right or the left parts of the screen. In the congruent trials, the arrow location and direction matched. In the incongruent trials, they mismatched, thus creating cognitive interference. In 50% of trials, the arrow presentation was accompanied by a task-irrelevant but environmentally meaningful sound that created perceptual interference. Hand dexterity was measured with the 9-hole peg test. Significantly faster reaction time (RT) on the modified Simon task (p < 0.001) was observed in younger adults, trials with concurrent sound stimuli, and congruent trials. Older adults who reported recent falls had greater difficulty resolving cognitive interference than older adults without recent falls. Hand dexterity significantly moderated the effect of sound on RT, but only in the group of older individuals. Interestingly, older individuals with reduced hand dexterity benefited from concurrent sounds more than those with better hand dexterity. Our findings suggest that task-irrelevant but environmentally meaningful sounds may increase alertness and enhance stimulus perception and recognition, thus improving motor performance in older individuals.
Using a Smartwatch to Record Precordial Electrocardiograms: A Validation Study

Smartwatches that support the recording of a single-lead electrocardiogram (ECG) are increasingly being used beyond the wrist, by placement on the ankle and on the chest. However, the reliability of frontal and precordial ECGs other than lead I is unknown. This clinical validation study assessed the reliability of an Apple Watch (AW) to obtain conventional frontal and precordial leads as compared to standard 12-lead ECGs in both subjects without known cardiac anomalies and patients with underlying heart disease. In 200 subjects (67% with ECG anomalies), a standard 12-lead ECG was performed, followed by AW recordings of the standard Einthoven leads (leads I, II, and III) and precordial leads V1, V3, and V6. Seven parameters (P, QRS, ST, and T-wave amplitudes, PR, QRS, and QT intervals) were compared through a Bland–Altman analysis, including the bias, absolute offset, and 95% limits of agreement. AW-ECGs recorded on the wrist but also beyond the wrist had similar durations and amplitudes compared to standard 12-lead ECGs. Significantly greater amplitudes were measured by the AW for R-waves in precordial leads V1, V3, and V6 (+0.094 mV, +0.149 mV, +0.129 mV, respectively, all p < 0.001), indicating a positive bias for the AW. AW can be used to record frontal, and precordial ECG leads, paving the way for broader clinical applications.
Stability Properties of Implicit Runge–Kutta Methods

New stability concepts—$BS$-stability and $BSI$-stability (internal $BS$-stability)—are introduced. $BS$-stability is a modification and extension of B-stability and enables the derivation of order results for Runge–Kutta methods applied to general nonlinear stiff initial value problems. These order results (B-consistency, B-convergence) are not affected by stiffness. Several classes of implicit Runge–Kutta methods are shown to be $BS$-stable: Gauss, Radau IA and Radau IIA schemes.
Prevalence of nut allergen sensitization among children in central Poland

Introduction The diagnostics of plant-derived food allergy may be challenging. However, the recognition of sensitization patterns in defined populations, especially in children, is clinically relevant as it enables the use of secondary prophylaxis to prevent life-threatening complications. Aim To investigate the rates and sensitization patterns to nut allergens in children from central Poland. Material and methods The retrospective assessment concerned data of 598 children diagnosed in a single centre due to suspected food allergy. The analysis included the results of component-based multiparametric assay Allergy Explorer2 (ALEX2). Results The sensitization to particular nut allergens varied among patients, depending on their age and nut type. The sensitization to any nut was found in 67% of children, whereas sensitization to hazelnut and peanut was the most common (56% and 55% of all children, respectively). Hazelnut sensitization was predominant in every age, and its prevalence increased with age, while peanut sensitization was detected in more than half of individuals from all groups, except for teenagers (44% of cases). Among hazelnut molecules sensitization to Cor a 1.04 was the most prevalent (74% of sensitized children), and for peanut allergens – Ara h 1 (65% of sensitized patients). The simultaneous sensitization to hazelnut, peanut and walnut (two or all of them) was found in almost half of the entire group. Conclusions Component-based diagnostics enables differentiation between primary and cross-reactive sensitization to nut allergens and detects co-sensitization. The clinical relevance of the latter observation is remarkable as co-sensitization increases the risk of life-threatening reactions even in trace nut contamination.
Introduction to interactive boundary layer theory

One of the major achievements in fluid mechanics in the last quarter of the twentieth century has been the development of an asymptotic description of perturbations to boundary layers known generally as 'triple deck theory'. These developments have had a major impact on our understanding of laminar fluid flow, particularly laminar separation. It is also true that the theory rests on three quarters of a century of development of boundary layer theory which involves analysis, experimentation and computation. All these parts go together, and to understand the triple deck it is necessary to understand which problems the triple deck resolves and which computational techniques have been applied. This book presents a unified account of the development of laminar boundary layer theory as a historical study together with a description of the application of the ideas of triple deck theory to flow past a plate, to separation from a cylinder and to flow in channels. The book is intended to provide a graduate level teaching resource as well as a mathematically oriented account for a general reader in applied mathematics, engineering, physics or scientific computation.
Robust interest points matching based on local description and spatial constraints

Matching of interest points is a key and an essential step in image description and search with local features. In this paper, we present a new matching method based on the prediction validation principle by matching pairs of interest points with their local description and with adding spatial constraints. The proposed method is independent of the detection process in order to obtain robust estimates of matching points under different changes likes scale, orientation, illumination. Our new matching method is based on two main steps: the first step computes local features around interest points. In the second step, we add some spatial constraints in order to enhance the robustness of the matches. The experimental setup shows that the proposed method can produce robust matches with higher repeatability and reasonable computational efficiency compared to some state of the art algorithms.
Association Between Sensitivity to Thyroid Hormone Indices and Diabetic Retinopathy in Euthyroid Patients with Type 2 Diabetes Mellitus

Objective Normal thyroid hormone (TH) levels and their relation to microvascular complications in patients with type 2 diabetes mellitus (T2DM) have been studied. However, the relationship between TH sensitivity and diabetic retinopathy (DR) remains unclear. Thus, this study aimed to investigate the relationship between TH sensitivity and the risk of DR in euthyroid T2DM patients. Methods This retrospective study analyzed 422 T2DM patients and calculated their sensitivity to TH indices. Multivariable logistic regression, generalized additive model, and subgroup analysis were performed to examine the association between sensitivity to TH indices and DR risk. Results After adjusting for covariates, the binary logistic regression model showed no statistically significant association between the sensitivity of TH indices and the risk of DR in euthyroid T2DM patients. However, a non-linear relationship was found between sensitivity to TH indices (thyroid-stimulating hormone index, thyroid feedback quantile index [TFQI]) and the risk of DR in the crude model; TFQI and DR in the adjusted model. The inflection point of the TFQI was 0.23. The effect size (odds ratio) on the left and right of the inflection point were 3.19 (95% confidence interval [CI]: 1.24 to 8.17 p=0.02) and 0.11 (95% CI: 0.01, 0.93 p=0.04), respectively. Moreover, this relationship was maintained by men stratified by sex. In euthyroid patients with T2DM, an approximate inverted U-shaped relationship and a threshold effect were demonstrated between TH index sensitivity and DR risk with sex differences. This study provided an in-depth understanding of the relationship between thyroid function and DR, which has important clinical implications for risk stratification and individual prediction.
A genome–wide CRISPR activation screen identifies SCREEM a novel SNAI1 super-enhancer demarcated by eRNAs

The genome is pervasively transcribed to produce a vast array of non-coding RNAs (ncRNAs). Long non-coding RNAs (lncRNAs) are transcripts of >200 nucleotides and are best known for their ability to regulate gene expression. Enhancer RNAs (eRNAs) are subclass of lncRNAs that are synthesized from enhancer regions and have also been shown to coordinate gene expression. The biological function and significance of most lncRNAs and eRNAs remain to be determined. Epithelial to mesenchymal transition (EMT) is a ubiquitous cellular process that occurs during cellular migration, homeostasis, fibrosis, and cancer-cell metastasis. EMT-transcription factors, such as SNAI1 induce a complex transcriptional program that coordinates the morphological and molecular changes associated with EMT. Such complex transcriptional programs are often subject to coordination by networks of ncRNAs and thus can be leveraged to identify novel functional ncRNA loci. Here, using a genome-wide CRISPR activation (CRISPRa) screen targeting ∼10,000 lncRNA loci we identified ncRNA loci that could either promote or attenuate EMT. We discovered a novel locus that we named SCREEM (SNAI1 cis-regulatory eRNAs expressed in monocytes). The SCREEM locus contained a cluster of eRNAs that when activated using CRISPRa induced expression of the neighboring gene SNAI1, driving concomitant EMT. However, the SCREEM eRNA transcripts themselves appeared dispensable for the induction of SNAI1 expression. Interestingly, the SCREEM eRNAs and SNAI1 were co-expressed in activated monocytes, where the SCREEM locus demarcated a monocyte-specific super-enhancer. These findings suggest a potential role for SNAI1 in monocytes. Exploration of the SCREEM-SNAI axis could reveal novel aspects of monocyte biology.
Genomic Characterization of a Vancomycin-Resistant Strain of Enterococcus faecium Harboring a rep2 Plasmid

Purpose In China, vancomycin-resistant enterococci (VRE) was not a common occurrence, and research on the genetic context and transmission mechanism of vanA-plasmid was scarce. The aim of this study was to molecularly characterise a vancomycin-resistant Enterococcus faecium isolate from a bloodstream infection and determine the genetic environment and delivery pattern of the plasmid carrying vancomycin-resistant gene. Materials and Methods In May 2022, a vancomycin-resistant strain of Enterococci was identified during routine screening for VRE bacteria at the First Affiliated Hospital, Zhejiang University School of Medicine. Utilizing matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS), the isolate was accurately identified. Antimicrobial susceptibility and whole-genome sequencing (WGS) were employed to perform phenotypic and genomic analysis, respectively. Further bioinformatics analyses was carried out to characterize the vanA-bearing plasmid. Results The antimicrobial susceptibility test showed that SJ2 strain was resistant to multiple antimicrobials, including ampicillin, benzylpenicillin, ciprofloxacin, erythromycin, levofloxacin, streptomycin, and vancomycin. Whole-genome analysis revealed that SJ2 strain carries several antimicrobial resistance genes and virulence determinants. MLST analysis found that SJ2 strain belongs to an unknown ST type. Plasmid analysis confirmed that the vanA gene was located on a variant of ~50 kb rep2 plasmid. Conclusion Our study found that vanA-bearing rep2 plasmid is a potential source of dissemination and outbreak, and continuous surveillance is necessary to control its spread in Hangzhou, China.
Life Habits of Healthcare Professionals during the Third Wave of COVID-19: A Cross-Sectional Study in a Spanish Hospital

(1) Background: To describe sleep quality, eating behaviour and alcohol, tobacco and illicit drug use among healthcare staff in a Spanish public hospital. (2) Methods: Cross-sectional descriptive study examining sleep quality (Pittsburg Sleep Quality Index), eating behaviour (Three Factor Eating Questionnaire (R18)), tobacco and drug use (ESTUDES questionnaire) and alcohol use (Cut down, Annoyed, Guilty, Eye-opener). (3) Results: 178 people, of whom 87.1% (155) were women, with an average age of 41.59 ± 10.9 years. A total of 59.6% of the healthcare workers had sleep problems, to a greater or lesser degree. The average daily consumption was 10.56 ± 6.74 cigarettes. The most commonly used drugs included cannabis, occasionally used by 88.37%, cocaine (4.75%), ecstasy (4.65%) and amphetamines (2.33%). A total of 22.73% of participants had increased their drug use, and 22.73% had increased their consumption during the pandemic, with beer and wine accounting for 87.2% of drinks consumed during this period. (4) Conclusions: In addition to the psychological and emotional impact already demonstrated, the COVID-19 crisis has repercussions on sleep quality, eating behaviour and alcohol, tobacco and drug consumption. Psychological disturbances have repercussions on physical and functional aspects of healthcare workers. It is feasible that these alterations are due to stress, and it is necessary to act through treatment and prevention as well as promote healthy habits.
On the persistence of trailing vortices

The short-wave stability properties of a Batchelor vortex are used to explain the intrinsic resistance of vortices to turbulent diffusion. We show that turbulence produced within the vortex core has to overcome a stabilizing ‘dispersion buffer’, where energy of the perturbations is dispersed by inertial waves without interfering with the mean flow, before they can reach the periphery of the vortex. While angular momentum is maintained by this mechanism, the difference in energy extraction by turbulence from the axial and tangential velocity fields due to a lack of alignment between the mean and turbulent strain tensors, a typical effect of flow rotation or curvature, leads to stabilization through a progressive damping of the axial shear in the vortex core. We show that the efficiency of these stabilizing mechanisms depends on the swirl number, the ratio between the maximum tangential velocity and the axial velocity difference. If the swirl parameter is low enough, turbulence is able to reach the vortex periphery and a small circulation overshoot develops, leading to weak diffusion of angular momentum outward.
Vertical electron content from ionograms in real time

A new technique for calculating the vertical total electron content (TEC) from ground‐based ionosonde measurements is introduced. The ionogram provides the information to directly calculate the vertical electron density profile up to the peak of the F2 layer. The profile above the peak is approximated by an α‐Chapman function with a scale height that is derived from the profile shape around the F2 peak. The ionosonde TEC, or ITEC, is then calculated as the integral from 0 to ∞ over the entire profile. ITEC values from Digisonde observations at Millstone Hill, Wallops Island, and Jicamarca are compared with incoherent scatter radar and with Faraday and TOPEX satellite TEC measurements, showing very good agreement at middle latitudes and the magnetic equator.
Organizational Principles of the Centrifugal Projections to the Olfactory Bulb

Centrifugal projections in the olfactory system are critical to both olfactory processing and behavior. The olfactory bulb (OB), the first relay station in odor processing, receives a substantial number of centrifugal inputs from the central brain regions. However, the anatomical organization of these centrifugal connections has not been fully elucidated, especially for the excitatory projection neurons of the OB, the mitral/tufted cells (M/TCs). Using rabies virus-mediated retrograde monosynaptic tracing in Thy1-Cre mice, we identified that the three most prominent inputs of the M/TCs came from the anterior olfactory nucleus (AON), the piriform cortex (PC), and the basal forebrain (BF), similar to the granule cells (GCs), the most abundant population of inhibitory interneurons in the OB. However, M/TCs received proportionally less input from the primary olfactory cortical areas, including the AON and PC, but more input from the BF and contralateral brain regions than GCs. Unlike organizationally distinct inputs from the primary olfactory cortical areas to these two types of OB neurons, inputs from the BF were organized similarly. Furthermore, individual BF cholinergic neurons innervated multiple layers of the OB, forming synapses on both M/TCs and GCs. Taken together, our results indicate that the centrifugal projections to different types of OB neurons may provide complementary and coordinated strategies in olfactory processing and behavior.
Classification Performance of the Ages and Stages Questionnaire: Influence of Maternal Education Level

(1) Background: The Ages and Stages Questionnaire—Third Edition (ASQ-3) is a parental screening questionnaire increasingly being used to evaluate the development of preterm children. We aimed to assess the classification performance of the ASQ-3 in preterm infant follow-up. (2) Methods: In this cross-sectional study, we included 185 children from the SEVE longitudinal cohort born <33 weeks of gestational age between November 2011 and January 2018, who had both an ASQ-3 score at 24 months of corrected age (CA) and a revised Brunet–Lézine (RBL) scale score at 30 months of CA. The ASQ-3 overall score and sub-scores were compared to the RBL developmental quotient (DQ) scores domain by domain. The diagnostic performance of the ASQ-3 was evaluated with the RBL as the reference method by calculating sensitivity, specificity, and positive and negative likelihood ratios. A multivariate analysis assessed the association between low maternal education level and incorrect evaluation with the ASQ-3. (3) Results: The ASQ-3 overall score had a specificity of 91%, a sensitivity of 34%, a positive likelihood ratio of 3.82, and a negative likelihood ratio of 0.72. Low maternal education level was a major risk factor for incorrectly evaluating children with the ASQ-3 (odds ratio 4.16, 95% confidence interval 1.47–12.03; p < 0.01). (4) Conclusions: Regarding the low sensitivity and the impact of a low maternal education level on the classification performance of the ASQ-3, this parental questionnaire should not be used alone to follow the development of preterm children
Multiproxy Reconstructions of Integral Energy Spectra for Extreme Solar Particle Events of 7176 BCE, 660 BCE, 775 CE, and 994 CE

Extreme solar particle events (ESPEs) are rare and the most potent known processes of solar eruptive activity. During ESPEs, a vast amount of cosmogenic isotopes (CIs) 10Be, 36Cl, and 14C can be produced in the Earth's atmosphere and deposited in natural stratified archives. Accordingly, CI measurements in these archives allow us to evaluate particle fluxes during ESPEs. In this work, we present a new method of ESPE fluence (integral flux) reconstruction based on state‐of‐the‐art modeling advances, allowing to fit together different CI data within one model. We represent the ESPE fluence as an ensemble of scaled fluence reconstructions for ground‐level enhancement (GLE) events registered by the neutron monitor network since 1956 coupled with satellite and ionospheric measurements data. Reconstructed ESPE fluences appear softer in its spectral shape than earlier estimates, leading to significantly higher estimates of the low‐energy (E < 100 MeV) fluence. This makes ESPEs even more dangerous for modern technological systems than previously believed. Reconstructed ESPE fluences are fitted with a modified Band function, which eases the use of obtained results in different applications.
Stability and bounds for single server queues in random environment

We consider a single server queue where the speed of the server is a function of a random environment. The only assumptions concerning the arrival process (arrival dates and service requirements) and the speed process are stationarity and ergodicity. A general expression is given for the stability condition. In the case where the two processes are independent, we show that the workload in this queue is larger for convex ordering than the workload in a queue with the same arrival process but fixed deterministic speed taken as the average of the speed process.
The shear Alfvén continuous spectrum of axisymmetric toroidal equilibria in the large aspect ratio limit

Analytic forms for the MHD continuous spectra in axisymmetric tokamak equilibria are derived using an expansion scheme in powers of the small inverse aspect ratio. Resulting formulae for the shear Alfvén continuum have been evaluated for the shear Alfvén wave heating experiment on the Tokapole II device at the University of Wisconsin-Madison. Mode coupling, induced by toroidicity or non-circularity, is shown to occur, in first order, on and near rational surfaces for particular poloidal and toroidal mode numbers. The coupling is shown to produce gaps in the spectrum, analogous to the gaps which appear in the energy spectrum of a single electron in a periodic potential lattice.