Miracle-dz/UniFAR-FTUs huggingface dataset:
COPD_A_276314 2923..2929

1Department of Respiratory Medicine, Japanese Red Cross Ishinomaki Hospital, Ishinomaki, Miyagi, Japan; 2Department of Pulmonary Medicine, Sendai Kosei Hospital, Sendai, Miyagi, Japan Purpose: Asthma–COPD overlap (ACO) has been reported as an association with a lower quality of life, frequent exacerbations, and higher mortality than those with COPD alone. However, clinical characteristics and outcomes of ACO remain controversial. Patients and Methods: We conducted a prospective observational study analyzing data of patients with stable COPD enrolled from the Ishinomaki COPD Network Registry. Patients with features of asthma who had a history of respiratory symptoms that vary over time and intensity, together with documented variable expiratory airflow limitation, were identified, and then defined as having ACO. The characteristics, frequency of exacerbations, and mortality during the 3-year follow-up were compared between patients with ACO and patients with COPD alone. Results: Among 387 patients with COPD, 41 (10.6%) were identified as having ACO. Patients with ACO tended to be younger, have higher BMI, have a shorter smoking history, and use more respiratory medications, especially inhaled corticosteroids. Inflammatory biomarkers including fractional exhaled nitric oxide, blood eosinophil count, total immunoglobulin E (IgE) level, and presence of antigen-specific IgE were significantly higher in patients with ACO than in those with COPD alone. Lung function, mMRC score, CAT score, and comorbidity index were not different between the groups. The annual rate of all exacerbations and severe exacerbations required hospital admission were not different between ACO and COPD alone (0.20 vs 0.14, 0.12 vs 0.10, events per person, respectively). Mortality was significantly higher in patients with COPD alone compared with those with ACO during the study period (P=0.037). Conclusion: The results of our study indicate that ACO is not associated with poor clinical features nor outcomes in an outpatient COPD cohort receiving appropriate treatment.
Determining the influence of information privacy concerns and trust of citizens on the attitude towards the Dutch COVID passport using PLS-SEM.

The covid passport is a new phenomenon introduced in 2021 and used as a tool to curb the spread of COVID-19 virus.This quantitative, confirmatory study aims to test the privacy and trust concerns of individuals in relationship to the attitude towards a COVID passport. The privacy calculus framework forms the foundation of the conceptual model in order to get a grasp of the privacy concerns of individuals. The seven constructs of this model were: perceived effectiveness of technological mechanism, perceived effectiveness of regulatory mechanism, individuals trust, perceived benefits, information privacy concerns, convenience and attitude towards COVID passport. Data was collected through an online survey and spread through convenience sampling. The Partial Least Squares Structural Equation Modeling method is applied to draw inferences from the gathered data. This study concludes that all relationships between the constructs are found to be statistically significant, with the only exception being the relationship between convenience and attitude towards a COVID passport. New research could shed light to further investigate attitudes towards a COVID passport, considering an adequate sample of the population to determine causality. As this study focuses mainly on the Netherlands, it would be important to investigate whether the results in the other countries differ from those in the Netherlands. In short, this would make it possible to see whether attitudes towards a COVID passport are significantly different in other countries.
Disruption to control network function correlates with altered dynamic connectivity in the wider autism spectrum.

Autism is a common developmental condition with a wide, variable range of co-occurring neuropsychiatric symptoms. Contrasting with most extant studies, we explored whole-brain functional organization at multiple levels simultaneously in a large subject group re ﬂ ecting autism's clinical diversity, and present the ﬁ rst network- based analysis of transient brain states, or dynamic connectivity , in autism. Disruption to inter-network and inter-system connectivity, rather than within individual networks, predominated. We identi ﬁ ed coupling disruption in the anterior-posterior default mode axis, and among speci ﬁ c control networks specialized for task start cues and the maintenance of domain-independent task positive status, speci ﬁ cally between the right fronto-parietal and cingulo-opercular networks and default mode network subsystems. These appear to propagate downstream in autism, with signi ﬁ cantly dampened subject oscillations between brain states, and dynamic connectivity con- ﬁ guration di ﬀ erences. Our account proposes speci ﬁ c motifs that may provide candidates for neuroimaging biomarkers within heterogeneous clinical populations in this diverse condition.
Proliferation and Survival The Erk2 MAPK Regulates CD8 T Cell

The magnitude of T cell responses is determined by proliferation and survival decisions made by the responding cells. We now demonstrate that the Erk MAPK pathway plays a critical role in these cell fate decisions within CD8 T cells. While Erk1 is dispensable for all aspects of CD8 T cell activation, Erk2 is required for the proliferation of CD8 T cells activated in the absence of costimulation. Surprisingly, Erk2 is not required for proliferation following the addition of a costimulatory signal in vitro, or upon viral infection in vivo, but regulates the size of the responding population by enhancing cell survival. An important com-ponent of this Erk2-derived signal is the transcriptional regulation of Bcl-2 family members Bcl-x L and Bim, and impaired Erk2-deﬁcient CD8 T cell survival can be rescued by genetic ablation of Bim. These studies ascribe multifaceted functions speciﬁc to Erk2 in CD8 T cell activation, proliferation, and survival. The Journal of Immunology, 2008, 181: 7617–7629.
Sentiment Analysis on Maltese using Machine Learning

—Sentiment analysis refers to the task of analysing a piece of text and classifying it according to the overall sentiment of the opinion being expressed. In this paper, we present a novel, supervised context based, machine learning system capable of performing such a task for text written in Maltese. Our system consists of two components both capable of performing classiﬁcation of Maltese text at a context window level, yet while one follows the more traditional approach where features are hand-crafted and passed on for classiﬁcation, the other performs unsupervised feature extraction and makes use of a deep learning algorithm. Through experimentation we determined that a Random Forest classiﬁer in conjunction with 80% of our dataset for training and a four word context window achieved the best results, and were successful in achieving an accuracy of 62.3%.
Association of Cervical Intraepithelial Lesions in Women with Genital Warts; A Cytological and Molecular Study

Background: Cervical cancer is a major health concern worldwide, according to the World Health Organization. It is now the fourth most common cancer after breast, colorectal and lung cancers in women worldwide. It is also the world's third most common cause of cancer death in women. objective of the study is to clarify association between genital warts & cervical intraepithelial lesions using cervical smear cytology with real time PCR. Methods: The study was carried out at The Department of gynecology & dermatology in Tanta University Hospitals. 50 patients were included started from June 2019 to June 2020. Results: From June 2019 to June 2020, 50 married women with genital warts are include in the study. Ten women out of 50 were married twice. Number of pregnancies ranged from 0 to 4 with a median (IQR) of 2.56. As regard LSIL group; 6 patients were infected by low risk HPV genotypes while only 2 patients had a mixed infection with high risk HPV genotypes. While all HSIL patients were infected by high risk HPV genotypes. Conclusions: The cytological characteristics of HPV on cervical smear appear to be non-specific. Therefore, PCR for HPV should be made use of as an adjunct to cervical smears in high risk patients to diagnose and follow up early cervical intraepithelial lesions.
Microplastics Reduce the Growth of Exposed Marine Invertebrates: A Meta-Analysis

There is a need for a quantitative approach to ascertain whether microplastic pollutants functionally affect exposed organisms. This meta-analysis aimed to determine if microplastics reduce the mean growth of exposed aquatic invertebrates in the marine environment. Twelve studies investigating microplastic exposure were submitted to meta-analytic techniques to obtain the overall combined effect. The random effects model was used. Standardized mean difference in growth was reported as Hedges’ g value. The robustness of the data was confirmed through a leave-one-out method of sensitivity analysis. Results shown by forest plot suggested that overall, the samples exposed to microplastics had lesser mean length after the exposure period as compared to samples not treated with microplastics. Mean difference in growth was equal to -1.324, as given by standardized Hedges’ g. A sensitivity analysis using leave-one-out method further showed that the data were robust, confirming overall reduction in growth. Growth reduction could be attributed to the size-selective ingestion of microplastics by the organisms, whereby they ingest smaller microplastic particles more readily than larger ones. Ingestion and egestion of microplastic particles entail an energetic cost for organisms, consequently reducing energy devoted to growth. The findings showed that microplastics can negatively influence the growth and eventually the overall well-being of marine organisms.
Parameters Aﬀecting Antiradical, Elemental Composition and Microstructural Elucidation in the Heat Reﬂux Extraction of Dried Piper nigrum Seedlings

Background: Black- and white pepper extracts are natural products, which had been extensively used in food industries as a sea-soning agent, and in herbal medicine for the treatment of many free radical-related diseases. Owing to the medicinal and nutritive beneﬁts of this functional spice, the need then arises to ﬁnd a way of extracting its ﬁxed oil at optimum condition. Objectives: Theaimof thisstudywastoinvestigatetheeﬀectof extractionparametersontheextractionyield,antioxidantactivities, microstructure, functional group characteristics, and elemental composition of ﬁxed oils extracted from the two cultivars. Methods: Extraction of ﬁxed oil was carried out using a heat reﬂux extraction technique. The dietary elemental composition was conducted using Energy Dispersive Spectroscopy (EDS). The eﬀect of localized heating on the extracts was evaluated to determine the structural changes in the pepper sample using Brunauer-Emmett-Teller (BET) and Scanning Electron Microscopy (SEM). Results: Theoptimalﬁxedoilyieldsundertheoptimumconditionwere10. 38mg/gfortheblackpepperand15.27forthewhitepep-per. Theantiradicalpowers(ARP)of 0.007985and0. 009046mL/ µ gwereobtainedforblack-andwhitepepperﬁxedoil,respectively. This suggests that the ﬁxed oil from white pepper exhibited higher antiradical characteristics than black pepper ﬁxed oil. The re-sultsof BET-parametersrevealedthepercentageof deformationsrelatedtotheblack-andwhitepepperunderthelocalizedheating was 21.47% and 29.14%, respectively. Conclusions: The results revealed a greater deformation on the microstructure of white pepper than black pepper. Moreover, rich dietaryelementspresentintheextractssuccinctlyunveiledthepotentialof ﬁxedoilextractsincurativeapplicationsandpreventive traditional medicine.
EEG NEUROFEEDBACK AND ADHD IN CHILDREN

: Attention Deficit Hyperactivity Disorder (ADHD) often manifests during childhood, and typically impacts children from the age of four to fifteen. There is a lack of optimum levels of catecholamine’s like dopamine and norepinephrine present. Psychostimulants such as methylphenidate and phenethylamine, modulate these catecholamine’s, which are the primary treatment option for ADHD in children. These drugs remain the treatment of choice, but their long-term effect and safety is still under scrutiny. Non-pharmaceutical treatment options for this complex disorder may be of benefit in this population, with fewer side effects, whose incidence is 8-12% of children worldwide. This preliminary review of the literature is guided by two questions: 1) How electroencephalogram-neurofeedback (EEG-NF) reduces inattention, hyperactivity, and impulsivity in children diagnosed with ADHD and 2) what are some of the limitations of this treatment modality. Hypovolemia of PFC is detected in ADHD and it is associated with the symptoms of inattention. Several studies in this review have suggested that NF training produced microstructural changes in the gray and white matter of the cerebral cortex. Increases in alpha wave and reduction in beta wave brain function are often found on the electroencephalogram in ADHD. Electroencephalogram-neurofeedback (EEG-NF) provides a continuous feedback. The study participants showed improved attention, cognitive functions, reduced distractibility, and improvement in IQ. This treatment modality utilizes operant conditioning and trained children to gain control of their cortical functions. This paper explores the impact of NF on ADHD symptoms, it also provides a brief overview of neuroanatomy and neurotransmitters of this disorder, electroencephalogram, the even related potential, biomarkers of EEG, side effects of medical regimens, and limitations of NF.
STUDY OF COMPARISON OF ENDOSCOPIC VERSUS CONVENTIONAL SEPTOPLASTICY IN THE KOLHAN BELT POPULATION OF JHARKHAND

BACKGROUND: DNS is common problem in all age group of both sexes as DNS is an idiopathic problem and challenge to otolaryngologist hence both methods have been used to compare the pros and cons of both techniques and evaluate the least post-surgical complications. METHODS: Out of 50 patients 25 treated with conventional septoplasty and 25 Endoscopic septoplasty problems associated with various nasal DNS. Right hypertrophied polypoid concha bullosa nasal discharge were operated by both methods and post-surgical complications were Bleeding 0% in Endoscopic septoplasm (ES) and 1 (4%) in conventional septoplasty (CS), synechiae 1 (4%) in ES, 2 (8%) in CS, DNS, 2 (8%) in ES and 4 (16%) in CS Epistaxis was observed in both ES and CS 1 (4%) but crusting was observed only in CS 2 (8%). were observed in conventional septoplasty as comparative Endoplastic CONCLUSION: septoplasty because ES is more illuminative, least incision, precise cutting is an ideal for Nasal disease in all age groups of both sexes.
Machine Learning Classi�cation of Traumatic Brain Injury Patients and Healthy Controls Using Multiple Indices of Diffusion Tensor Imaging

Background: Diffusion tensor imaging (DTI) indices provide quantitative measures of white matter microstructural changes following traumatic brain injury (TBI). However, there is still insu�cient evidence for their use as predictive measures. Recently, there has been growing interest in using machine learning (ML) approaches to aid the diagnosis of many neurological and psychiatric illnesses including TBI. The aim of this study is to examine the potential of using multiple DTI indices in conjunction with ML to automate the classi�cation of healthy subjects and patients with TBI across a spectrum of TBI severity. Methods: Participants were adult patients with chronic TBI (n=26) and age and gender-matched healthy controls (n=26). DTI images were obtained from all the participants. Tract-based spatial statistics (TBSS) analysis was applied to the DTI images. Classi�cation models were built using principle component analysis (PCA) and support vector machines (SVM). Receiver operator characteristic (ROC) curve analysis and area under the curve (AUC) were used to assess the classi�cation performance of the different classi�ers. Results: The whole-brain white matter TBSS analyses showed signi�cantly decreased FA, as well as increased MD, AD, and RD in TBI patients compared with healthy controls (all p-value < 0.01). The PCA and SVM-based ML classi�cation using combined DTI indices classi�ed TBI patients and healthy controls with the accuracy of 90.5% with an area under the curve (AUC) of 93 +/- 0.09. Conclusion: This study demonstrates the potential of a joint DTI and ML approach for objective classi�cation of TBI patients and healthy controls.
SAFE APPROACH TO CONTROL Fusarium oxysporum IN SESAME CROP

: Our study aimed to use antagonistic fungi, bacteria and chemical formulation, to practically control Fusarium oxysporum , the causal of seasame root-rot and wilt diseases. Trichoderma harzianum, Bacillus subtilis , Pseudomonas fluorescens and chemical antifungal agent (Bion) were tested to evaluate thier capabilities to inhibit Fusarium oxysporum growth in vitro and to control the disease in greenhouse and field trials . All evaluated treatments in the present study, significantly decreased the diseases incidence in the greenhouse compared to control. T . harzianum treatment scored as the most effective one in control study, followed by B. subtilis and P. fluorescens while Bion gave the lowest effect in this regard. Field experiments at Assiut Governorate, during 2016 and 2017 growing seasons were tried. Results of field experiments were conformed with those obtained from the greenhouse experiment. All treatments increased plant height, number of fruiting branches, number of bearing capsules, seed yield per sesame plant and influenced percentage of oil content of sesame plants positively.
Role of foxc1a in somitogenesis Zebrafish foxc1a plays a crucial role in early somitogenesis by restricting the expression of aldh1a2

Background: The role of foxc1a in zebrafish somitogenesis remains elusive. Results: Zebrafish foxc1a knockout embryos exhibit defective somites at early development. foxc1a works on the top of the genetic hierarchy of RA, Fgf and Notch signaling network to regulate myod1 expression. Conclusion: Foxc1a controls zebrafish early somitogenesis by directly restricting aldh1a2 expression. Significance: The results reveal the genetic role of foxc1a in zebrafish early somitogenesis. ABSTRACT Foxc1a is a member of forkhead transcription factors. It plays an essential role in zebrafish somitogenesis. However, little is known about the molecular mechanisms underlying its controlling somitogenesis. To uncover how foxc1a
4th Time Around: Do Classes Get Better with Instructor Repetition?

This complete, evidence-based practice paper presents a study that compares student learning outcomes and perceptions of class experience for students enrolled in different sections of a course taught by the same instructor in the same semester. For a variety of reasons, instructors in first-year engineering programs are particularly likely to lead multiple sections of a course each semester. A commonly held perception among instructors is that student grades and student course evaluations improve, on average, in sections that are taught during later repetitions within their daily or weekly schedule. Relatedly, instructors (and students) commonly think of an early morning class as less effective than a class later in the day; however, the cause may be—at least in part—due to the fact that an earlier class is more likely to be the first time this semester that the instructor is teaching that day’s content. In this paper, we describe our findings in a study that compiles data from multiple instructors and multiple years. Final semester grades were used as a metric of student learning outcomes, and responses to quantitative questions in the end-of-semester student course evaluation surveys were used as a metric of student perceptions of their class experience. Contrary to instructor perceptions, only a slight improvement of a few percentage points in the student perceptions was found for the third section in the instructor’s week. This increase was found across multiple metrics and, though small, is found to be statistically significant. A case study of a new instructor teaching new content is included, examining the confounding factors that may be masking the expected impact of improvement with repetition. This paper will answer these as well as other questions by comparing student learning outcomes and perceptions of class experience for students enrolled in different sections of a first-year cornerstone of engineering course taught by the same instructor in the same semester. The data is compiled from the end-of-term course evaluation surveys administered anonymously by the university over a period of several years. Final semester grades are used as a metric of student learning outcomes, and responses to quantitative questions in the end-of-semester student course evaluations are used as a metric of student perceptions of their class experience.
Arrangement of Growing Space in Rows and Application of Liquid Organic Fertilizer to Intercropping Yields of Onions and Soybeans

The research was to obtain optimal rabbit urine POC concentrations and space to grow in rows to provide high yields for intercropping shallots and soybeans. The results showed that the interaction of rabbit urine POC concentration with the growing room and the treatment room had no significant effect (P≥0.05) on all observed variables. The highest yields of shallot bulbs per clump and per hectare were obtained at the concentration of POC rabbit urine 150 ml.l-1, namely 66.87 g and 6.69 tons, increasing 35.28% and 35.42% compared to the lowest yields at POC concentrations. 25 ml.l-1 i.e. 49.43 g and 4.94 tons. The highest yield of soybean per plant and hectare was obtained at the concentration of POC rabbit urine 150 ml.l-1, namely 32.38 g and 4.32 tons, an increase of 56.47% and 57.09% compared to the lowest yield at the concentration of POC. 25 ml.l-1 i.e. 2.75 tons and 20.63 g.
THE EFFECTS OF PROPISCIN (ETOMIDATE) ON THE BEHAVIOUR, HEART RATE, AND VENTILATION OF COMMON CARP, CYPRINUS CARPIO L.

The effects of Propiscin (etomidate) on the behaviour, heart and of 34 (2): Background. The use of anaesthetics in aquaculture requires conducting specific studies of their effects on fish. The objective of this study was to evaluate the effects of Propiscin (Polish agent containing etomidate) on common carp behaviour, heart rate, and ventilation. Material and methods. Carp were anaesthetised with Propiscin at the concentrations of 1 and 2 ml·l -1 . An electrocardiograph was used to record the heart rate and the amplitude and rate of the opercular movements. The effects of atropine and forced water flow over the gill system on the anaesthetised carp’s heart rate were also studied. Results. At either concentration, Propiscin caused general anaesthesia manifesting itself in: a loss of equilibrium, faded responses to external stimuli, gradual ventilation failure, and bradycardia. A high correlation between respiration rate and heart rate was found in the anaesthetised fish. Conclusion. The hypoxia was the direct cause of bradycardia, and the regularity and amplitude of breathing were the most important indicators of the level of Propiscin-evoked anaesthesia.