Miracle-dz/UniFAR-FTUs huggingface dataset:
Multilevel Spine Injuries: A 15-Year Institutional Experience

Methods: Patients with congenital, metabolic, rheumatologic diseases and neoplasms were excluded. Each level of vertebral injury was designated as primary, secondary or tertiary. The pattern of these injuries was plotted and compared with that in Jefferson’s series. Neurological functions were evaluated according to the American Spinal Injury Association (ASIA). Modified Prolo Economic Functional Rating Scale was used to assess the functional outcome. All of the statistical calculations were performed using the Statistical Package for Social Sciences and p<0.05 was considered statistically significant.
Difficulties in the diagnosis aetiology of A- β- ketosis-prone diabetes in a North- African adult

Ketosis-prone diabetes (KPD) is a heterogeneous syndrome characterized by patients who present with diabetic ketoacidosis or unprovoked ketosis but do not necessarily have the typical phenotype of autoimmune type 1 diabetes. In this case report, we expose the difficulties in the diagnosis aetiology of Aβketosis-prone diabetes (KPD) in a 22-year-old North-African woman presenting with diabetic ketoacidosis. Her initial glycaemia was at 17.2 mmol/L and glycated haemoglobin (HbA1c) was moderately increased at 7.6% with no clinical evidence of other precipitating illnesses or stressful events. Her baseline and glucagon-stimulated serum C-peptide levels were below the detection limit at the time of admission. All anti-pancreatic antibodies were negative and pancreatic imaging was normal. Direct sequencing of HNF1A, HNF4A, INS, IPF1, NEUROD1 and PAX4 genes were performed and showed three mutations in HNF1A (I27L), NEUROD1 (A45T) and PAX4 (H321P). HLA typing showed the genotype DQB1*03DRB1*11/DQB1*03-DRB1*13. Based on that data, type 1A diabetes mellitus (DM) could be excluded. However, criteria of fulminant type 1 DM are mostly filled but difficult to be confirmed and the MODY (Maturity Onset diabetes of the young) hypothesis could not be ruled out as other genes may be involved. Our observation highlights the difficulties of understanding the aetiology of AβKPD with sudden-onset although clinical, imaging, immunologic and genetic data are available.
Pharmacological inhibition of mTORC1 increases CCKBR-specific tumor uptake of radiolabeled minigastrin analogue [177Lu]Lu-PP-F11N

Rationale: A high tumor-to-healthy-tissue uptake ratio of radiolabeled ligands is an essential prerequisite for safe and effective peptide receptor radionuclide therapy (PRRT). In the present study, we searched for novel opportunities to increase tumor-specific uptake of the radiolabeled minigastrin analogue [177Lu]Lu-DOTA-(DGlu)6-Ala-Tyr-Gly-Trp-Nle-Asp-Phe-NH2 ([177Lu]Lu-PP-F11N), that targets the cholecystokinin B receptor (CCKBR) in human cancers. Methods: A kinase inhibitor library screen followed by proliferation and internalization assays were employed to identify compounds which can increase uptake of [177Lu]Lu-PP-F11N in CCKBR-transfected human epidermoid carcinoma A431 cells and natural CCKBR-expressing rat pancreatic acinar AR42J cells. Western blot (WB) analysis verified the inhibition of the signaling pathways and the CCKBR level, whereas the cell-based assay analyzed arrestin recruitment. Biodistribution and SPECT imaging of the A431/CCKBR xenograft mouse model as well as histological analysis of the dissected tumors were used for in vivo validation. Results: Our screen identified the inhibitors of mammalian target of rapamycin complex 1 (mTORC1), which increased cell uptake of [177Lu]Lu-PP-F11N. Pharmacological mTORC1 inhibition by RAD001 and metformin increased internalization of [177Lu]Lu-PP-F11N in A431/CCKBR and in AR42J cells. Analysis of protein lysates from RAD001-treated cells revealed increased levels of CCKBR (2.2-fold) and inhibition of S6 phosphorylation. PP-F11N induced recruitment of β-arrestin1/2 and ERK1/2 phosphorylation. In A431/CCKBR-tumor bearing nude mice, 3 or 5 days of RAD001 pretreatment significantly enhanced tumor-specific uptake of [177Lu]Lu-PP-F11N (ratio [RAD001/Control] of 1.56 or 1.79, respectively), whereas metformin treatment did not show a significant difference. Quantification of SPECT/CT images confirmed higher uptake of [177Lu]Lu-PP-F11N in RAD001-treated tumors with ratios [RAD001/Control] of average and maximum concentration reaching 3.11 and 3.17, respectively. HE staining and IHC of RAD001-treated tumors showed a significant increase in necrosis (1.4% control vs.10.6% of necrotic area) and the reduction of proliferative (80% control vs. 61% of Ki67 positive cells) and mitotically active cells (1.08% control vs. 0.75% of mitotic figures). No significant difference in the tumor vascularization was observed after five-day RAD001 or metformin treatment. Conclusions: Our data demonstrates, that increased CCKBR protein level by RAD001 pretreatment has the potential to improve tumor uptake of [177Lu]Lu-PP-F11N and provides proof-of-concept for the development of molecular strategies aimed at enhancing the level of the targeted receptor, to increase the efficacy of PRRT and nuclear imaging.
MiR-218 inhibits malignant phenotypes of glioma by targeting TNC/AKT/AP-1/TGFβ1 feedback signaling loop

Background: Gliomas are the most malignant and common tumors in human brains, and the prognosis of glioma patient is very poor. MicroRNAs (miRNAs) play critical roles in different types of cancer by performing posttranscriptional regulation of gene expression. Although miR-218 has been demonstrated decreased in gliomas, its role in gliomas still remains largely unknown. Methods: MiR-218 expression were analyzed in gliomas and normal brain tissues (control subjects) using TCGA dataset. A series of in vitro and in vivo studies was performed to determine the biological roles of miR-218 in glioma cells. Potential targets of miR-218 were identified using dual-luciferase reporter system. Western blot and dual-luciferase reporter system were performed to evaluate the regulatory effect of miR-218 on TNC/AKT/AP-1/TGFβ1 pathway.Results: We demonstrated miR-218 was significantly downregulated in gliomas compared to control subjects, and played potent tumor suppressor roles in glioma cells by inhibited cell proliferation, colony formation, migration, invasion and tumorigenic potential in nude mice, as well as inducing cell cycle arrest and apoptosis.Mechanistically, miR-218 inhibited malignant phenotypes of glioma cells by binding to the 3’ UTR of its target TNC and subsequently repressing its expression. As a result, it could reduce AKT phosphorylation and subsequently inhibit transcriptional activity of AP-1 by reducing JNK phosphorylation, downregulating the expression of TGFβ1, while TGFβ1 is able to, in turn, activate the TNC/AKT/AP-1 signaling axis.Conclusions: Our data uncover a previously unknown tumor suppressor role of miR-218 by blocking the TNC/AKT/AP-1/TGFβ1 positive feedback loop in glioma.
Effects of Indole-3-carbinol on Inflammatory and Prooncogenic Mediators in Solid Ehrlich Carcinoma Induced Mice

Indole-3-carbinol (I3C) and its metabolites were proven to suppress the proliferation of various cancer cell lines by targeting a wide spectrum of signaling pathways that regulate hormonal homeostasis, cell cycle progression, and cell proliferation. Moreover, I3C inhibited tumorigenesis in mammary glands, liver, lung, and gastrointestinal tract in different animal models. These preclinical findings demonstrate the value of I3C in cancer prevention and therapy, which has led to its trial in cervical dysplasia, breast cancer, leukemia and recurrent respiratory papillomatosis. This study aimed to investigate the effects of different doses of I3C on inflammatory mediators, IL-6 and TNF-α levels and prooncogenic mediator, SphK1 activity, in tumor tissue in Solid Ehrlich Carcinoma (SEC) Tumor Model. Eighty BALB/c male mice were used in this study. Except for mice in the control group, each mouse was implanted subcutaneously with 0.2 ml of the ascites fluid containing 1x10 6 Ehrlich carcinoma cells (ECCs) into the thigh of the hind limb. Mice were divided into four groups (20 mice per group) as follow: Control group, Solid Ehrlich carcinoma (SEC) control group, Indole-3-carbinol (I3C 1000 ppm) group, in which mice were put on a diet containing 1000 ppm I3C starting seven days before and continued for 42 days after tumor inoculation, Indole-3-carbinol (I3C 2000 ppm) group, in which mice were put on a diet containing 2000 ppm I3C starting seven days before and continued for 42 days after tumor inoculation. Administration of I3C (1000 and 2000 ppm) to ECCs-bearing mice resulted in significant decrease in tumor volume and increased survival rate. Subcutaneous implantation of ECCs resulted in significant increase in tumor tissue SphK1 activity, TNF-α and IL-6 levels and administration of I3C (1000 and 2000 ppm) to ECCs-bearing mice resulted in significant decrease in all of these oncogenic and inflammatory mediators.
Explosive Bubbles and Cyclical Linkages of the Asia Pacific Housing Prices

This study assesses the housing bubbles and cyclical linkages of housing prices across ten APE, the US and UK from1990Q1-to2013Q4. The sequential unit root tests (SADF and GSADF) have detected multiple and periodically collapsing bubbles for most economies (except Japan and Thailand), which occurred before the Asia Financial Crisis, during the 2000s boom and after the 2008 subprime crisis. Analysis also reveals that APE housing prices are characterized by comparable cyclical pattern and the cycles are closely linked. Domestic markets are vulnerable to regional and global shocks. The finding may contradict the efficient market hypothesis but the real time feature of the bubble tests makes it appealing to policy makers for early detection and correction of market failure. As for stakeholders, new investment strategies are essential in portfolio diversification. Overall, our study offers adequate instruments for future diagnosis of housing prices. The outcome provides fundamental elements of an early warning system against economic instability.
ABS Braking Control Enhancement Via Fractional Order Extremum Seeking Method

This paper focuses on the development of a robust Fractional Order Extremum-Seeking (FOES) scheme for controlling the ABS of vehicle motion system by continuously adjusting the brake torque. Extremum Seeking (ES) known for its properties to seek the maximum of unknown function and Fractional Order (FO) control for its robustness in the presence of parameter variations and the disturbances are employed to control the wheel slip rate in emergency braking maneuver. The aim of an ABS is to minimize brake distance while steer ability is retained even under hard braking, to understand the fundamental physical effect, which leads to wheel blocking during braking. Simulations under various road conditions are performed to demonstrate the effectiveness of the proposed control scheme.
Intellectual Capital, Capital Structure And Growth Of The Company And Its Implications On Value Index Formers Lq-45

The purposes of this study is to investigate the effect of intellectual capital, capital structure and growth of the company and its implications on value index formers LQ-45. The population of this study is all companies forming the LQ-45 index of the 2012 to 2018 period. Then, the sample of this study is only the companies that recorded consistent over the study period. This study uses regression analysis. The results indicate that intellectual capital proxied by variables VACA, VAHU and STVA partially have no significant effect on the capital structure, but have significant effect on the company's growth. Intellectual capital proxied by variables VACA, VAHU and STVA has significant effect on the value of the company; nevertheless, intellectual capital proxied by variables VAIC TM has no significant effect on the company’s capital structure, but has significant positive effect on the company's growth. On the other hand, the company's growth significantly influence the company’s capital structure, and the company’s capital structure significantly influence the company’s firm value, but the effect of company's growth is not significant
Relationship between Visual Impairment of Elderly and Their Quality of Life

Visual function is the most important sensory function of the human body; visual impairment is a common and debilitating health problem among elderly. It is affected elderly s’ daily life and leads to functional disabilities and other health problems. Thus: The aim of the current study was to assess relationship between visual impairment of elderly and their quality of life. Design: A descriptive correlational research design was adopted in this study. Setting: The study was conducted at outpatient clinics in Governmental Ophthalmic Hospital in Kafer El-Sheikh governorate, Egypt. Tools: Data were collected through interviewing elderly using two tools: I) Elderly Client Interviewing Questionnaire Tool which divided into two parts, 1st part: the demographic characteristics of the elderly and 2 nd part: medical history and chronic disease. II) An Arabic Version of National Eye Institution Visual Function Questionnaires Tool (ARB-VFQ-25). Results: results revealed that, the main cause for visual impairment was cataract (84%). The highest mean score of subscale were vision health and color vision (66.13±34.67). A statistically significance correlation was found between visual impairment and quality of life among elderly (p= 0.012). Conclusion: Visual impairment is associated with significant reduction in different quality of life domains for the elderly. Quality of life becomes poor with increasing severity of visual impairment. Recommendations: the study recommended conducting a health education programs for elderly with visual impairment to promote their quality of life.
Corporate Reputation and CSR- Oriented Personal Factors Affecting Consumer Loyalty and Purchase Satisfaction towards Green Products in Thailand

This research aimed to (1) examine the corporate reputation and CSRoriented personal factors affecting consumer loyalty in Thai people who purchase green products, and (2) investigate the influence of corporate reputation, CSR-oriented personal factors, and consumer loyalty on consumer purchase satisfaction in Thai people. A total of 389 usable questionnaires were analysed in this research. The purposive and convenience sampling method was performed. Descriptive statistics, exploratory factor analysis, correlation analysis, and multiple regression analyses have been employed. The results found that (1) the averages of organisational reputation, personal factors, consumer loyalty, and purchase satisfaction were at a high level, (2) corporate reputation and personal factor had a significant positive influence on consumer loyalty, (3) four key variables affect consumer loyalty in green purchasing, including: the organisation has a credible reputation, the organisation has conducted socially responsible activities, the organisation offers accurate and complete information, and consumers live in accordance with environmental conservation, and (4) two key variables of corporate reputation, including: the organisation has a credible reputation and the organisation discloses information for easy access, which had a positive effect on the purchase satisfaction of consumers.
Family Control, Profitability, Dividend Payment Rate, and Foreign Ownership Moderation

This study aims to determine the relationship of family control to profitability and the level of dividend payments, with foreign ownership as a moderating variable. 399 observations of manufacturing companies listed on the IDX from 2013-2017 are used. This study uses multiple linear regression methods to determine the effect of family control on profitability and the level of dividend payments moderated by foreign ownership. This study shows that family control negatively effects the level of profitability and dividend payments inside a company. Furthermore, a foreign ownership fund is proven to be able to mitigate the negative influence of family control both regarding the profitability of a company and its level of dividend payments.
The efficacy of group counselling on perceived stress among infertile women undergoing in vitro fertilization treatment: An RCT

Abstract Background One of the stressful and critical experiences that threat the individual, family, marital, and social stability is infertility. Objective To identify the effects of midwifery-led counselling programs on the perceived stress of the women undergoing assisted reproductive treatment. Materials and Methods In this randomized clinical trial, 50 infertile women who underwent in vitro fertilization treatment for the first time were enrolled in two groups. The intervention group received six sessions of group counselling by M.Sc. midwifery of counseling student and the control group received only the routine care. All participants filled Newton's standard questionnaire before and at the time of puncture, embryo transfer and the pregnancy test. Results The mean ± SD scores for the perceived infertility stress before the intervention in the control and the intervention groups were 167.92 ± 12.14 and 166.75 ± 13.27, respectively. The mean of perceived stress after intervention at the time of oocyte puncture in the control and case group were 177.12 ± 19.37 and 115.75 ± 13.88, at the time of embryo transfer were 179.40 ± 18.34 and 118.08 ± 15.37, and at the time of pregnancy test was 183.76 ± 14.97 and 120.50 ± 16.24, respectively. The perceived stress of infertility after intervention were statistically significant in the two group (p ≤ 0.001). Conclusion Group counselling is one of the effective methods for reducing the perceived stress in the women undergoing assisted reproductive treatment.
Expression of Hypoxic Inducible Factor-1α Induced by Ginkgolides in PC12 Cells

OBJECTIVE To study the effects of ginkgolides(Gin) on the expression of hypoxia inducible factor-1α(HIF-1α) in differentiated PC12 cells induced by NGF and the involved signal pathways.METHODS The viability of PC12 cells treated with different concentration of Gin was determined by MTT assay.The expressions of HIF-1α and ERK induced by Gin were detected by Western Blot and the expression of HIF-1α mRNA was checked by RT-PCR.RESULTS Gin enhanced the viability of PC12 cells in some concentration ranges and reached the peak effect at 37.5 mg·L~(-1). Both of the mRNA and the protein level of HIF-1α were induced by the treatment with 37.5 mg·L~(-1)for 24 h.Gin induced the expression of phosphorylation of ERK(p-ERK). Further,Gin enhanced the stability of HIF-1α expression in a time-and dose-dependent manner.This enhancement was partially inhibited by the pretreatment with PD98059,a mitogen-activated protein kinase-1(MEK1) inhibitor and completely blocked by genistein,a tyrosine kinase inhibitor.Meanwhile,the activation of p-ERK was increased in a time and dose-dependent manner by Gin and completely blocked by the pretreatment of PD98059 and genistein in PC12 cells.CONCLUSION Gin can induce the expression of HIF-1α in PC12 cells,which may be mediated through the activation of MAPK signal pathway.
A MATHEMATICAL MODEL FOR HUMAN AND ANIMAL LEPTOSPIROSIS

In this paper, we propose a SI model for the study of human and animal leptospirosis. Unlike other models for leptospirosis which consider only rodents as infection vectors, we consider that humans can be infected not only through contact with rodents, but also through any other animal that serves as a reservoir for the bacteria, and through contact with bacteria that are free in the environment. We calculate the basic reproductive number for this model, which is given in terms of the basic reproductive numbers of simpler subsystems of the original model, and propose some intervention techniques for controlling the disease based on our results.
Response of hybrid rice to scheduling of nitrogen and irrigation during dry season

Field experiment were conducted to study the performance of hybrid rice to scheduling of irrigation and nitrogen level. Nitrogen scheduling of 40+20+30+10 percent at basal, active tillering, panicle initiation and flowering reduced the sterility percentage and increased effective tillers and grain yield of hybrid rice. Irrigation, one day after disappearance of water proved as good as continuous submergence for yield components, grain yield and N content in stem and leaf at early stages, flag leaf, grain and straw. The irrigation schedule of one day after disappearance of ponded water required 604 mm less irrigation water than that of maintaining continuous submergence.
Field survey on evaluation of seed quality traits and storage methods used in the legume crops by the house hold farmers in jhansi district of Uttar Pradesh, India

The present investigation was conducted to assess the seed quality and storage methods of seeds of legume crops (Green gram. Black gram, Chickpea and Pea) by famers in Jhansi district of Uttar Pradesh during 2008. A survey was carried out in 51 rural households of nine villages viz, Karari, Rudra Karari, Peetampura, Hatanapur, Ambabvay, Padari, Mathanpura, Keshavpur and Bhooda located within a range of 20 km Jhansi district of Uttar Pradesh. Seeds of different legume crops which were stored for sowing purpose were sampled using standard sampling procedures from farmers’ household to estimate the seed moisture(%), purity(%), germination(%) and health status. Seventy nine seed samples were collected for crops representing the routine cropping pattern practiced by the farmers. Seed storage as well as the quantity of the storage decided the type of the container and their storage methods. The commonly used methods and containers are Polythene lined urea bag, Jute bag, Room storage, Bunnda, Metal container, Plastic container and Mud pot. Analysis of the physiological seed quality of farmers saved seeds of indicated that 80% samples could meet out the IMSCS of 75 per cent germination and maximum damage due to insect pests was about 6%. The current evidence on farmer’s seed samples indicated that storage methods and seed quality parameters need to be improved to increase yield.
A comparative review of fisheries management experiences in the European Union and in other countries worldwide: Iceland, Australia, and New Zealand

This study compares the details and performance of fisheries management between the EU and a selection of other countries worldwide: Iceland, New Zealand, and Australia, which are considered in many respects to be among the most advanced in the world in fisheries management. Fisheries management in the EU, Iceland, Australia, and New Zealand has developed following different paths, despite being based on similar instruments and principles. Iceland, Australia, and New Zealand have been at the forefront of developing management practices such as stakeholder involvement, legally binding management targets (Australia, New Zealand), individual transferable quotas, and discard bans (Iceland, New Zealand). The EU has since the beginning of the 21st century taken significant steps to better involve stakeholders and establish quantitative targets through management plans, and a landing obligation is gradually being implemented from 2015 onward. The management of domestic fisheries resources in Australia, New Zealand, and Iceland has, overall, performed better than in the EU, in terms of conservation and economic efficiency. It should, however, be stressed that, compared to Australia, New Zealand, and Iceland, (i) initial over-capacity was more of an issue in the EU when management measures became legally binding and also that (ii) EU has been progressive in developing common enforcement standards, on stocks shared by sovereign nations. The situation of EU fisheries has substantially improved over the period 2004–2013 in the northeast Atlantic, with fishery status getting close to that in the other jurisdictions, but the lack of recovery for Mediterranean fish stocks remains a concern.