Miracle-dz/UniFAR-FTUs huggingface dataset:
Primary Cilium Identifies a Quiescent Cell Population in the Human Intestinal Crypt

Primary cilia are sensory antennae located at the cell surface which mediate a variety of extracellular signals involved in development, tissue homeostasis, stem cells and cancer. Primary cilia are found in an extensive array of vertebrae cells but can only be generated when cells become quiescent. The small intestinal epithelium is a rapidly self-renewing tissue organized into a functional unit called the crypt–villus axis, containing progenitor and differentiated cells, respectively. Terminally differentiated villus cells are notoriously devoid of primary cilia. We sought to determine if intestinal crypts contain a quiescent cell population that could be identified by the presence of primary cilia. Here we show that primary cilia are detected in a subset of cells located deep in the crypts slightly above a Paneth cell population. Using a normal epithelial proliferative crypt cell model, we show that primary cilia assembly and activity correlate with a quiescent state. These results provide further evidence for the existence of a quiescent cell population in the human small intestine and suggest the potential for new modes of regulation in stem cell dynamics.
Evaluation of the susceptibility to green stem disorder in soybeans [Glycine max (L.) Merr.] with vegetative storage protein accumulation

ABSTRACT Green stem disorder (GSD) is an important agronomical problem in soybean production because it delays leaf and stem senescence and complicates the harvest. However, a rapid and precise diagnosis of GSD has not yet been established. In this study, the effect of depodding on GSD and vegetative storage protein (VSP) accumulation was investigated in GSD-susceptible cultivar ‘Tachinagaha (Tc)’ and GSD-resistant experimental line ‘Touhoku 129 (Th)’ under two different (early and late) sowing dates in 2020 and 2021. Intact Tc plants showed relatively severe GSD at early sowing in 2020 and late sowing in 2021, whereas intact Th plants showed little GSD at both sowing dates and in both years. Meanwhile, depodding reproducibly induced GSD and increased stem weight for both Tc and Th. The relative VSP content peaked 14–21 days after R3 (DAR3) in intact plants and increased afterward in depodded plants. The relative VSP content differed at 28 DAR3 between intact and depodded plants, which was earlier than the timing when SPAD (soil plant analysis development) values differed, suggesting that VSP accumulation might be a better indicator of GSD than the SPAD value. The present study will contribute to the development of tools for diagnosing GSD. GRAPHICAL ABSTRACT
Medical Professionals’ Knowledge, Sensitivity, and Attitudes Towards Social and Ethical Aspects of Stem-Cell Donation, Therapy, and Research: Implications for Healthcare Risk Management

Background Knowledge, sensitivity, and acceptance attitudes towards social, moral and ethical aspects of stem-cell donation and treatment are important factors in preventing professional negligence and improving healthcare risk management and health justice in this specialized area of health services. Objective To assess knowledge, sensitivity, acceptance and rejection attitudes towards stem-cell transplantation and research and its associated factors among medical professionals in Saudi Arabia. Methods A quantitative and cross-sectional study was conducted in December 2022. Data were collected from 260 medical workers from various regions in Saudi Arabia. T-tests, ANOVA, and multiple linear regression were applied to find variations and associations of gender, age, profession, nationality, religious orientation, and work experiences of professionals with knowledge, sensitivity, acceptance and rejection attitude towards stem-cell donation, therapy, and research. A confidence interval (CI) of 95% and a significance level of p≤ 0.05 was chosen for testing statistical models. Results A total of (n=260) medical professionals, among which clinicians (n=98;38%), pharmacists (n=78;30%), and nurses (n=84;32%) completed the survey questionnaire. Findings show that (n=27; 10%) participants have work experience in stem-cell donation, (n=67; 26%) in stem-cell therapy, and (n=124; 48%) in stem-cell research. Clinicians and pharmacists, in comparison to nurses, had better knowledge (p<0.01 and p<0.05); pharmacists had higher sensitivity (p<0.05) than nurses. Compared to those who do not have work experience in stem-cell research, those who had work experience had higher levels of knowledge, sensitivity, and acceptance attitudes at (p<0.001) and (p<0.01). Acceptance attitudes are considerably higher among male participants than females and similarly higher among older participants than younger participants (p<0.05). Compared to non-Saudi nationals, Saudi nationals scored higher on rejection attitudes (p<0.01). Compared to those having work experience in stem-cell donation and research, those without work experience are more likely to hold rejection attitudes (p<0.01). Conclusion Findings suggest female professionals, Saudi nationals and those who do not have prior work experience in stem-cell donation, therapy, or research had low levels of knowledge, less sensitivity, and less acceptance attitude and are more likely to hold rejection attitude, signifying the need to address them to improve healthcare risk management.
Dynamic behavior of earth dams under different kinematic impacts

The paper provides a detailed analysis of the current state of the problem. A mathematical model is presented to determine the dynamic behavior of earth dams, considering the viscoelastic properties of soil, using the hereditary Boltzmann-Volterra theory with the A.R. Rzhanitsyn kernel under periodic kinematic impacts. To solve the problems considered, the finite element method and complex arithmetics were used to reduce integrodifferential equations to a high-order complex algebraic equation. The accuracy of the methods was verified by solving test problems. Steadystate forced vibrations of the Pskem earth dam 195 m high are studied considering the real geometry and soil properties under resonant vibration modes. It was stated that the largest stress amplitudes in the body of the dam occur not only under the first resonance, but they can occur under other dense spectra of the eigenfrequencies of the dam, due to the interaction between close natural modes of vibration. The strength of various sections of the dam body was tested under kinematic impact using the Coulomb- Mohr theory of strength; the most dangerous sections of the dam were identified in terms of the highest stress.
Use of Continuous Glucose Monitors to Manage Type 1 Diabetes Mellitus: Progress, Challenges, and Recommendations

Abstract Type 1 diabetes (T1D) management has been revolutionized with the development and routine utilization of continuous glucose monitoring (CGM). CGM technology has allowed for the ability to track dynamic glycemic fluctuations and trends over time allowing for optimization of medical therapy and the prevention of dangerous hypoglycemic events. This review details currently-available real-time and intermittently-scanned CGM devices, clinical benefits, and challenges of CGM use, and current guidelines supporting its use in the clinical care of patients with T1D. We additionally describe future issues that will need to be addressed as CGM technology continues to evolve.
The decay power law in grid-generated turbulence

The effect of initial conditions on the decay exponent and coefficient and virtual origin in the decay power-law form for the variation of the variance of the turbulent velocity downstream of biplane grids constructed of rods of both round and square cross-section is determined. This effect is determined for data obtained as part of the present study as well as from previous studies. These studies cover a Reynolds number range from 6000 to 68000, mesh sizes of 2.54 and 5.08 cm, and solidities of 0.34 and 0.44. It is shown that the choice of the virtual origin and the use of data in the non-homogeneous portion of the flow can have a significant influence on the value of the parameters in the decay power-law. Criteria are developed to identify the nearly homogeneous and isotropic portion of the flow. These criteria include low values of the velocity skewness, constancy of the skewness of the velocity derivative and balance of the turbulent kinetic energy equation. Results based on data selected by means of these criteria show that the decay exponent and virtual origin are independent of initial conditions such as Reynolds number, mesh size, solidity, and rod shape and surface roughness with values of respectively 1.30 and 0. In contrast and as expected, the decay coefficient is found to be a function of these initial conditions. Thus, the downstream variation of the variance of the turbulent velocity is universally self-similar.
Description of a Cohort with a New Truncating MYBPC3 Variant for Hypertrophic Cardiomyopathy in Northern Spain

Background: The pathogenicity of the different genetic variants causing hypertrophic cardiomyopathy (HCM) and the genotype/phenotype correlations are difficult to assess in clinical practice, as most mutations are unique or identified in non-informative families. Pathogenic variants in the sarcomeric gene MYBPC3 inherited with an autosomal dominant pattern, whereas incomplete and age-dependent penetrance are the most common causes of HCM. Methods: We describe the clinical characteristics of a new truncating MYBPC3 variant, p.Val931Glyfs*120, in 75 subjects from 18 different families from northern Spain with the p.Val931Glyfs*120 variant. Results: Our cohort allows us to estimate the penetrance and prognosis of this variant. The penetrance of the disease increases with age, whereas 50% of males in our sample developed HCM by the age of 36 years old, and 50% of women developed the disease by the time they reached 48 years of age (p = 0.104). Men have more documented arrhythmias with potential risk of sudden death (p = 0.018), requiring implantation of cardioverter defibrillators (p = 0.024). Semi-professional/competitive sport among males is related to earlier onset of HCM (p = 0.004). Conclusions: The p.Val931Glyfs*120 truncating variant in MYBPC3 is associated with a moderate phenotype of HCM, with a high penetrance, onset in middle age, and a worse outcome in males due to higher risk of sudden death due to arrhythmias.
Evaluating the Effect of Descriptive Norms on Political Tolerance

Recent scholarship has documented changing norms toward political tolerance and an increase in intolerant beliefs in the United States. Descriptive norm theory attributes attitudinal and behavioral changes to beliefs about how we perceive other people think and act. Applied to political tolerance, increasing the perception that society is more or less tolerant should result in corresponding changes among individuals. Neglected from this discussion, however, is the distinction between norms that are applied universally and norms that are applied to specific targets. Four studies show mixed support for descriptive norm theory with norms altering individual tolerance judgments mostly when applied universally. Norms aimed at a particularistic group fail to change tolerance judgments suggesting an important limitation to norm influence. Contrary to expectations, we uncover a reversal effect among Democrats whereby exposure to universalistic norms of intolerance leads to higher levels of tolerance.
Increasing Vehicular Visible Light Communications Range Based on LED Current Overdriving and Variable Pulse Position Modulation: Concept and Experimental Validation

Due to its unique advantages, the integration of Visible Light Communications (VLC) in vehicle safety applications has become a major research topic. Nevertheless, as this is an emergent technology, several challenges must be addressed. One of the most important of these challenges is oriented toward increasing vehicular VLC systems’ communication range. In this context, this article proposes a novel approach that provides a significant communication distance enhancement. Different from most existing works on this topic, which are based on refining the VLC receiver, this new article is focused on improving the VLC system based on the benefits that can be achieved through the VLC transmitter. The concept is based on Light-Emitting Diode (LED) current overdriving and a modified Variable Pulse Position Modulation (VPPM). Therefore, LED current overdriving provides the VLC receiver higher instantaneous received optical power and improved Signal-to-Noise Ratio (SNR), whereas the use of the VPPM ensures that the VLC transmitter respects eye regulation norms and offers LED protection against overheating. The concept has been experimentally tested in laboratory conditions. The experimental results confirmed the viability of the concept, showing an increase of the communication range by up to 370%, while maintaining the same overall optical irradiance at the VLC transmitter level. Therefore, this new approach has the potential to enable vehicular VLC ranges that cover the requirements of communication-based vehicle safety applications. To the best of our knowledge, this concept has not been previously exploited in vehicular VLC applications.
Physicochemical, Nutritional, and Medicinal Properties of Opuntia ficus-indica (L.) Mill. and Its Main Agro-Industrial Use: A Review

The cactus, Opuntia ficus-indica (L.) Mill. (OFI) belongs to the Cactaceae family, which contains about 130 genera and nearly 1600 species. This review aims to evaluate this plant from several perspectives, namely, botanic, physicochemical, nutritional, and medicinal properties, as well as agro-industrial use. The botanical aspects and morphological characteristics of OFI enable genetic variability, ecological adaptation, and broad geographic distribution. Due to its physicochemical and nutritional composition, it has several medicinal properties appropriate (or suitable) for several industries, such as pharmaceutical, food, and cosmetics. Its fruit, the prickly pear (PP), has potential agro-industrial expansion through the application of different conservation and transformation methods, making it possible to obtain a variety of products. The PP is a source of several nutrients and is an effective system to produce varied foods, which have several advantages from a nutritional, sensory, economic, and shelf-life point of view.
Simulation of storm surges using a three‐dimensional numerical model: An application to the 1977 Andhra cyclone

A three-dimensional numerical model is developed for the simulation of storm surges generated by tropical cyclones off the east coast of India. Experiments are performed using wind-stress forcing data representative of the 1977 Andhra cyclone and the results are compared with earlier simulations using a depth-averaged model. The three-dimensional model incorporates a turbulence energy closure scheme and is fairly sophisticated in comparison with the depth-averaged approach. Even with the apparently more refined treatment of the frictional processes, there is no substantial difference between simulations performed with the two models.
Transfer-Path-Based Hardware-Reuse Strong PUF Achieving Modeling Attack Resilience With200 Million Training CRPs

This paper presents a hardware-reuse strong physical unclonable function (PUF) based on the intrinsic transfer paths (TPs) of a conventional digital multiplier to achieve a strong modeling attack resilience. With the multiplier input employed as the PUF challenge and the path delay as the entropy source, all the possible valid propagation paths from distinct input/output pairs can serve as PUF primitives. We can quantize the path delay using a time-to-digital converter (TDC), and select the suitable TDC output bits as the PUF response. We further propose a lightweight dynamic obfuscation algorithm (DOA) and a secure mutual authentication protocol to counteract modeling attacks. The proposed strong PUF using a <inline-formula> <tex-math notation="LaTeX">$32\times 32$ </tex-math></inline-formula> multiplier as implemented in the Xilinx ZYNQ-7000 SoC features a total of 2048 intrinsic PUF primitives, while achieving a response stream (RS) with an average of 1024 responses per TDC output bit per challenge. With <inline-formula> <tex-math notation="LaTeX">$Bit(5)$ </tex-math></inline-formula> and <inline-formula> <tex-math notation="LaTeX">$Bit(6)$ </tex-math></inline-formula> of the TDC output selected for PUF response generation, they demonstrate a measured reliability and uniqueness of up to 98.31% and 49.34%, respectively, with their excellent randomness performance as validated by the NIST SP800-22 tests. Under machine learning (ML)-based modeling attack with artificial neural network (ANN), the measured prediction accuracy of both <inline-formula> <tex-math notation="LaTeX">$Bit(5)$ </tex-math></inline-formula> and <inline-formula> <tex-math notation="LaTeX">$Bit(6)$ </tex-math></inline-formula> can still be maintained at <inline-formula> <tex-math notation="LaTeX">$\sim 50\%$ </tex-math></inline-formula> with a total of >200 million CRPs as the training set.
The surface brightness test for the expansion of the universe. I - Properties of Petrosian metric diameters

The surface brightness (SB) properties of E and S0 galaxies are presently studied over a range of absolute magnitudes in order to determine the intrinsic variation of SB at given M(B sub t) values. This would establish the basis for an observational test of Tolman's (1930, 1940) prediction of a bolometric SB decrease as (1 + z) to the 4th in an expanding universe and 1 + z if redshifting is not due to expansion. The definition of the Petrosian (1976) eta parameter is set out as a practical operational procedure; the properties of the eta(r) function are illustrated for the Hubble, Oemler, de Vaucouleurs, and King SB-fitting templates for E-galaxies. 39 refs.
Climate Warming Does Not Override Eutrophication, but Facilitates Nutrient Release from Sediment and Motivates Eutrophic Process

The climate is changing. The average temperature in Wuhan, China, is forecast to increase by at least 4.5 °C over the next century. Shallow lakes are important components of the biosphere, but they are sensitive to climate change and nutrient pollution. We hypothesized that nutrient concentration is the key determinant of nutrient fluxes at the water-sediment interface, and that increased temperature increases nutrient movement to the water column because warming stimulates shifts in microbial composition and function. Here, twenty-four mesocosms, mimicking shallow lake ecosystems, were used to study the effects of warming by 4.5 °C above ambient temperature at two levels of nutrients relevant to current degrees of lake eutrophication levels. This study lasted for 7 months (April–October) under conditions of near-natural light. Intact sediments from two different trophic lakes (hypertrophic and mesotrophic) were used, separately. Environmental factors and bacterial community compositions of overlying water and sediment were measured at monthly intervals (including nutrient fluxes, chlorophyll a [chl a], water conductivity, pH, sediment characteristics, and sediment-water et al.). In low nutrient treatment, warming significantly increased chl a in the overlying waters and bottom water conductivity, it also drives a shift in microbial functional composition towards more conducive sediment carbon and nitrogen emissions. In addition, summer warming significantly accelerates the release of inorganic nutrients from the sediment, to which microorganisms make an important contribution. In high nutrient treatment, by contrast, the chl a was significantly decreased by warming, and the nutrient fluxes of sediment were significantly enhanced, warming had considerably smaller effects on benthic nutrient fluxes. Our results suggest that the process of eutrophication could be significantly accelerated in current projections of global warming, especially in shallow unstratified clear-water lakes dominated by macrophytes.
Effects of Methylone Pre-Exposure on Fluoxetine-Induced Conditioned Taste Avoidance in Male and Female Sprague-Dawley Rats

Background: Prior work has reported that a drug’s aversive effects (as indexed by taste avoidance conditioning) are attenuated when the pre-exposure and conditioning drugs are the same or different. The latter, otherwise known as cross-drug pre-exposure, is especially interesting as it has been used as a tool to assess mechanisms underlying the aversive effects of drugs. We previously reported that methylone pre-exposure differentially impacted the aversive effects of MDPV and MDMA (MDPV > MDMA), a difference consistent with the dopaminergic mediation of methylone’s aversive effects. To examine the possible role of serotonin (5-HT) in methylone’s aversive effects, the present study assessed the effects of methylone pre-exposure on taste avoidance induced by the 5-HT reuptake inhibitor fluoxetine. Methods: Male and female Sprague-Dawley rats were exposed to 10 mg/kg of methylone every 4th day (for a total of 5 injections) prior to taste avoidance training with 10 mg/kg of fluoxetine. Results: Fluoxetine induced significant taste avoidance (each p < 0.05) that was independent of sex. Methylone pre-exposure had no impact on avoidance produced by fluoxetine in either males or females (each p > 0.05). Conclusions: Methylone pre-exposure had no impact on fluoxetine-induced avoidance. These findings suggest that it is unlikely that 5-HT mediates the aversive effects of methylone. The implications of the present results for the mechanisms mediating methylone’s aversive effects were discussed. Understanding such mechanisms is important in predictions relevant to drug history and abuse liability as a variety of subject and experiential factors known to affect (reduce) a drug’s aversive effects may increase its use and potential for abuse.
On d-inversion in interruptive timed discrete-event systems

The authors consider the problem of extracting event lifetimes from partial observations of an interruptive timed discrete-event system. The extraction of the lifetime of an occurring event is based on observations of all previous transitions and d-subsequent transitions. We refer to this notion as d-inversion. We give necessary and sufficient structural conditions for an event to be d-invertible in a given system.
Climate Defaults and Financial Adaptation

We analyze the relationship between climate-related disasters and sovereign debt crises using a model with capital accumulation, sovereign default, and disaster risk. We ﬁnd that disaster risk and default risk together lead to slow post-disaster recovery and heightened borrowing costs. Calibrating the model to Mexico, we ﬁnd that the increase in cyclone risk due to climate change leads to a welfare loss equivalent to a permanent 1% consumption drop. However, ﬁnancial adaptation via catastrophe bonds and disaster insurance can reduce these losses by about 25%. Our study highlights the importance of ﬁnancial frictions in analyzing climate change impacts.