Miracle-dz/UniFAR-FTUs huggingface dataset:
PERCEPTION, KNOWLEDGE AND ATTITUDE TOWARDS PATIENT SAFETY AMONG NURSING STUDENTS IN A PRIVATE COLLEGE IN MALAYSIA

Background: Patient safety is defined as the absence of preventable harm to a patient while providing health care, as well as the reduction of unnecessary harm associated with health care. The delivery of better healthcare requires the protection of patients. It is crucial to evaluate nursing students' knowledge and attitudes toward patient safety to identify deficiencies in the educational curriculum and encourage students in patient safety activities. Given the importance of patient safety today, the purpose of this study was to appraise nursing students' expectations, attitudes, and awareness regarding patient safety. Methods: This cross-sectional study was conducted in 2020 at one of the private university colleges in Malaysia. Ninety-two nursing students were recruited using the purposive sampling method. A self-administered questionnaire on patient safety was adapted. The data were analyzed using descriptive analysis and the Chi-square test. Results: The findings show that the nursing students had a positive perception of the importance of patient safety in both education and the need for adequate skills. Moreover, 90.3% of students demonstrated a positive attitude toward the importance of patient safety. The majority (98.9%) of the nursing students also demonstrated good knowledge about patient safety. The minimum desirable rates of positive responses (Likert 4 or 5) of 60% were exceeded among nursing students in all three aspects. Conclusion: Our findings can contribute to the growing knowledge base about students' patient safety competencies from various perspectives. A better understanding of these interconnected factors can help new graduates feel more confident in their patient safety skills. High patient safety skills can help nursing students provide safe patient care.
Electroanatomic substrate of atrial fibrillation in patients after COVID-19

Aim. To determine the features of left atrial electroanatomic structure and the arrhythmia substrate in patients with atrial fibrillation (AF) after coronavirus disease 2019 (COVID-19). Material and methods. The pilot study included 20 patients with AF who underwent catheter radiofrequency ablation. Ten patients had COVID-19 and 10 patients were included as a control group. AF substrate was identified using anatomic and bipolar mapping. Zones with following amplitudes were analyzed: <0,25 mV, <0,5 mV, from 0,5 to 0,75 mV inclusive, and >0,75 mV. Left atrial volume was determined based on anatomic map. Results. The groups were homogeneous in AF type, number of patients after prior pulmonary vein isolation, and heart rate during mapping. In the COVID-19 group, there was a higher area of fibrous zones with an amplitude of <0,25 mV (51,5±16,6% vs 29,1±16,1% in the control group, p=0,007), <0,5 mV (76,7±11,5% vs 45,6±22,7% in the control group, p=0,001) and a lower area of intact myocardium with an amplitude >0,75 mV (11,6±8,0% vs 45,0±25,0% in the control group, p=0,001). In 7 COVID-19 patients, the posterior wall was isolated due to low-amplitude zones. Of these, three patients underwent surgery for the first time. According to ROC analysis, in patients after COVID-19, fibrous tissue (<0,5 mV) occupies more than half of the area, while normal tissue (>0,75 mV) — ~30% or less. Conclusion. This study atrial remodeling in the form of diffuse fibrosis. The arrhythmia substrate in patients after COVID-19 can be localized not only in pulmonary vein mouths, but also in other left atrial areas. This must be taken into account before ablation, even if the procedure is being performed for the first time. It is recommended to perform amplitude mapping for all patients who have had SARS-CoV-2 infection in order to identify fibrous zones and plan the operation extent.
Diosgenin induces HIF-1 activation and angiogenesis through estrogen receptor-related PI3K/Akt and p38 MAPK pathways in osteoblasts

1 Diosgenin induces HIF-1 activation and angiogenesis through estrogen receptor-related PI3K/Akt and p38 MAPK pathways in osteoblasts Men Luh Yen, Jen Liang Su, Chung Liang Chien, Kuang Wen Tseng, Ching Yao Yang, Wei Fang Chen, Chiao Chia Chang and Min Liang Kuo Department of Primary Care Medicine, National Taiwan University and Department of Obstetrics and Gynecology, National Taiwan University Hospital (M.L.Y.); Institute of Toxicology, College of Medicine, National Taiwan University (J.L.S., C.Y.Y., W.F.C., C.C.C., M.L.K.); Department of Traumatology and Surgery, National Taiwan University Hospital (C.Y.Y.); Department of Anatomy and Cell Biology, College of Medicine, National Taiwan University (C.L.C., K.W.T)
Imaging phenotyping of perivascular fat by computerised tomography detects human coronary inflammation

Alexios S. Antonopoulos†, Fabio Sanna†, Nikant Sabharwal, Sheena Thomas, Evangelos K Oikonomou, Laura Herdman, Marios Margaritis, Cheerag Shirodaria, Anna-Maria Kampoli, Ioannis Akoumianakis, Mario Petrou, Rana Sayeed, George Krasopoulos, Constantinos Psarros, Patricia Ciccone, Carl M. Brophy, Janet Digby, Andrew Kelion, Raman Uberoi, Suzan Anthony, Nikolaos Alexopoulos, Dimitris Tousoulis, Stephan Achenbach, Stefan Neubauer, Keith M Channon, Charalambos Antoniades*
Validation of a simpli®ed medication adherence questionnaire in a large cohort of HIV-infected patients: the GEEMA

ow naded rom http:urnals.lw w om /aionline by hD M fePH bH 4TIm qVAH xkFJpPk1L/H vM G w qM xG jw O deJPG +b4D lKuA44qu/vw zm c= on 070/2018 Downloadedfromhttp://journals.lww. com/aidsonlinebyBhDMf5ePHKbH4TTImqenVAHxkFJp/XpPk1L/H3vMGwqMxG9jwOd8eJPG+b4DlKuAX44qu/vwzmc=on07/30/2018 Validation of a simpli®ed medication adherence questionnaire in a large cohort of HIV-infected patients: the GEEMA StudyHernando Knobel
This magnetic resonance imaging (MRI)-based morphometric analysis of cortical topography in the human brain is based upon the segmentation and parcellation of volumetric T1-weighted MRI data

This magnetic resonance imaging (MRI)-based morphometric analysis of cortical topography in the human brain is based upon the segmentation and parcellation of volumetric T1-weighted MRI data for a set of 20 young adult brains including 10 males and 10 females. For the most part, each parcellation unit (PU) of the neocortex corresponds to a single or a portion of a single gyrus. The volumes of each PU were computed for each brain. Subsets of PUs were also grouped so as to represent the neocortex for the frontal, temporal, parietal and occipital lobes. The coefficient of variation of the mean volume of total neocortex and that of the neocortex assigned to individual lobes cluster around 10%, whereas that of neocortex assigned to the individual gyri (PU) is more than twice that value. Approximately 80% of the total variance in gyral volume arises from determinants interactive for individual and specific gyri, while only ~ 10% of the total variance appears to be a reflection of uniform scaling to total neocortical volume. Sexual dimorphism contributes a pervasive though relatively small component of this variance. These results have implications for the study of structure–function correlation, and the proper statistical methods of handling volumetric data in morphometric studies. In addition, the nature of the covariance structure of the data will lead to future hypotheses regarding the relationships between the various potential genetic and epigenetic gyral influencing factors.
Two Etomidate Sites in (cid:1) 1 (cid:2) 2 (cid:3) 2 (cid:3) -Aminobutyric Acid Type A Receptors Contribute Equally and Noncooperatively to Modulation of Channel Gating

Background: Etomidate is a potent hypnotic agent that acts via (cid:1) -aminobutyric acid receptor type A (GABA A ) receptors. Evidence supports the presence of two etomidate sites per GABA A receptor, and current models assume that each site contributes equally and noncooperatively to drug effects. These assumptions remain untested. Methods: We used concatenated dimer ( (cid:2) 2- (cid:3) 1) and trimer ( (cid:1) 2- (cid:2) 2- (cid:3) 1) GABA A subunit assemblies that form functional (cid:3) 1 (cid:2) 2 (cid:1) 2 channels, and inserted (cid:3) 1M236W etomidate site mutations into both dimers ( (cid:2) 2- (cid:3) 1M236W) and trimers ( (cid:1) 2- (cid:2) 2- (cid:3) 1M236W). Wild-type or mutant dimers (D wt or D (cid:3) M236W ) and trimers (T wt or T (cid:3) M236W ) were coexpressed in Xenopus oocytes to produce four types of channels: D wt T wt , D (cid:3) M236W T wt , D wt T (cid:3) M236W , and D (cid:3) M236W T (cid:3) M236W . For each channel type, two-electrode voltage clamp was performed to quantitatively assess GABA EC 50 , etomidate modulation (left shift), etomidate direct activation, and other functional parameters affected by (cid:3) M236W mutations. Results: Concatenated
HORMONAL PROFILE IN EARLY MENOPAUSE

Early cessation of the cycle in the reproductive age is harsh for women. The aim of this study was to evaluate the hormonal profile in infertile Sudanese women complaining of premenopausal amenorrhea, including serum luteinizing hormone (LH), follicle stimulating hormone (FSH), thyroid stimulating hormone (TSH), prolactin and estradiol (E2). This case control- cross sectional study was done in the 5 clinics of infertility in tertiary care hospitals in Khartoum-Sudan, from: May 2012 to December 2014. The study included 323 infertile premenopausal amenorrheic women and 198 ages matched women with proven fertility as control. ELISA method was used to measure serum levels of FSH, LH, TSH, prolactin and E2. Data was analyzed by IBM, SPSS version 20. The mean of the prolactin in the amenorrheic women was (121.5±1 265.12)ng/ml versus (15.09± 6.07)ng/ml in the control group; with P. value (0.000), FSH (50.33 ± 34.04) IU/ml versus (8.71 ± 31.29) IU/ml; with P.value (0.000), LH (34.89± 22.71) IU/ml versus (6.27± 2.55) IU/ml; with P.value (0.000), TSH (1.75± 2.02)IU/ml) versus (1.27± 0.76) IU/ml; with P.value (0.004) and E2 (40.16± 34.30)pg/ml versus (50.68± 16.74)pg/ml ;with P value (0.029). The prevalence of secondary amenorrhea among the study group was 315 (97.5%). In premenopausal amenorrheic Sudanese; secondary amenorrheic is most common. Serum prolactin, FSH, LH, and TSH significantly increase; while estradiol significantly decreases.
A systematic phylogenetic approach to study the interaction of HIV-1 with coinfections, non-communicable and opportunistic diseases

To systematically test whether coinfections spread along the HIV-1 transmission network and whether similarities of HIV-1 genomes predict AIDS-defining illnesses and comorbidities, we analyzed the distribution of these variables on the HIV-phylogeny of the densely sampled Swiss HIV Cohort Study. By combining different statistical methods, we could detect, quantify and explain the clustering of diseases: Infectious conditions such as hepatitis C, but also Kaposi’s sarcoma, clustered significantly, suggesting transmission of these infections along the HIV-1 transmission network. The clustering of patients with neurocognitive complaints, however, could not be completely explained by the clustering of patients with similar demographic risk factors, which suggests a potential impact of viral genetics. In summary, the consistent and robust signal for infectious conditions highlights the strong interaction of HIV-1 and other infections and shows the potential of combining phylogenetic methods to identify disease traits that are likely to be related to virus genetic factors.
Cutaneous Sarcoidosis in African Americans

Background: Though African Americans are known to be at greater risk of acquiring sarcoidosis and developing more severe disease, few studies have analyzed the racial differences in cutaneous sarcoidosis. Aim: Our study sought to characterize patients’ cutaneous disease in terms of color and morphology, and to establish whether race, presence of cutaneous sarcoidosis, or specific lesion characteristics were associated with the age at diagnosis. Methods: Sarcoidosis patients’ charts were reviewed retrospectively for sex, race, and age at diagnosis. If present, cutaneous lesions were further characterized by color and morphology. Results: 491 patients had sarcoidosis, and 122 (25.3%) patients had cutaneous involvement. Black patients were more likely to have cutaneous involvement than white patients ( p <0.001). There was no difference in color or morphology of cutaneous lesions between black and white patients. Conclusions: Blacks are at higher risk for developing cutaneous disease, but, aside from lupus pernio, color and morphology of cutaneous sarcoidosis lesions are no different between black and white patients.
Special Section: Moving from Citizen to Civic Science to Address Wicked Conservation Problems Contributions of paraecologists and parataxonomists to research, conservation, and social development

Citizen science has been gaining momentum in the United States and Europe, where citizens are literate and often interested in science. However, in developing countries, which have a dire need for environmental data, such programs are slow to emerge, despite the large and untapped human resources in close proximity to areas of high biodiversity and poorly known floras and faunas. Thus, we propose that the parataxonomist and paraecologist approach, which originates from citizen-based science, is well suited to rural areas in developing countries. Being a paraecologist or a parataxonomist is a vocation and entails full-time employment underpinned by extensive training, whereas citizen science involves the temporary engagement of volunteers. Both approaches have their merits depending on the context and objectives of the research. We examined 4 ongoing paraecologist or parataxonomist programs in Costa Rica, India, Papua New Guinea, and southern Africa and compared their origins, long-term objectives, implementation strategies, activities, key challenges, achievements, and implications for resident communities. The programs supported ongoing research on biodiversity assessment, monitoring, and management, and participants engaged in nonacademic capacity development in these fields. The programs in Southern Africa related to specific projects, whereas the programs in Costa Rica, India, and Papua New Guinea were designed for the long term, provided sufficient funding was available. The main focus of the paraecologists’ and parataxonomists’ activities ranged from collection and processing of specimens (Costa Rica and Papua New Guinea) or of socioeconomic and natural science data (India and Southern Africa) to communication between scientists and residents (India and Southern Africa). As members of both the local land user and research communities, paraecologists and parataxonomists can greatly improve the flow of biodiversity information to all users, from local stakeholders to international academia. ¶email ute.schmiedel@uni-hamburg.de Paper submitted March 1, 2015; revised manuscript accepted August 19, 2015. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
Technology impacts on area, production and productivity of cashew in Dakshina Kannada district, Karnataka

The study analyses the technology impacts on area, production and productivity of cashew in the Dakshina Kannada district of Karnataka state, for combating low productivity and profitability from cashew cultivation. Results revealed that highest area under cashew is occupied by the variety Ullal-3 followed by Bhaskara with similar trend in adoption levels. The ‘Ullal-3 + Bhaskara’ combination emerged to be the most popular one among farmers in the study area. Farmers realized highest yield from cashew varieties such as Bhaskara and Madakkathara-2 followed by Ullal-1 and Ullal-3. Productivity under normal density (8 x 8 m) as well as high density (5 x 5 m) planting was highest for Bhaskara and Madakkathara-2. Correlation analysis showed that four technologies; soil and water conservation, pruning and training, plant protection and harvesting and post-harvest technologies had highly significant relation with the cashew production achieved by farmers. Increased adoption of soil and water conservation techniques, development and popularization of user friendly plant protection measures and adoption of viable intercrops can contribute largely to increase cashew production while increased adoption of pruning and training in cashew orchards can significantly increase the per unit productivity of cashew orchards. The study concludes that socio-economic and bio-physical factors along with policy environment have a larger contribution in explaining cashew production and productivity and technology component alone cannot be expected to bring a positive impact. Understanding the above dynamics in technology impact can help researchers and extension agencies working in cashew sector to design better innovations and effective outreach strategies.
How can we integrate students’ use of mobile devices within the lecture lesson plan and improve engagement?

It is becoming increasingly apparent that technology is ‘rewiring students’ brains’ (Briggs, 2014) and educators increasingly find mobile devices ‘impossible to ignore’ (Gerson, 2015). With the premise that the more time students spend as active participants in learning activities, the more they learn, this article considers how mobile phones can be used to benefit ‘digital native’ (Levy, 2014) students in the classroom. It explores the need to harness mobile technology as well as the distraction that these devices cause. In this new world of constant connectivity it is critical to engage students and integrate mobile phone use into the lesson plan, fully exploiting the technology to hand (Herlong, 2015).
Fiscal Policy and Non-Oil Output in Nigeria

: - The study examined fiscal policy and non-oil output in Nigeria from 1970-2017. Secondary data on government capital and recurrent expenditure for the study was collected from CBN statistical bulletin and the econometrics methods of ADF unit root test, Johansen co-integrated test and ECM technique were used for the analysis. The results of the output model showed that all the variables were stationarity at order one and have long run relationship. The parsimonious ECM result showed that a percentage increase government capital expenditure increases the non-oil sector output sector by about 29%. The coefficient of government recurrent expenditure showed that a percentage increase government recurrent expenditure will increase the non-oil sector output sector by about 2.0%. Given the scenario above, it was concluded that there is a direct relationship between government expenditure and non-oil output in Nigeria during the period of study. Based on these findings, it was recommended that the percentage of government capital budget should be more than recurrent as former play more vital role in the development of the non-oil output in Nigeria.
Cloning and Characterization of the (cid:98) Subunit of Human Proximal Sequence Element-Binding Transcription Factor and Its Involvement in Transcription of Small Nuclear RNA Genes by RNA Polymerases II and III

The proximal sequence element (PSE)-binding transcription factor (PTF), which binds the PSE of both RNA polymerase II- and RNA polymerase III-transcribed mammalian small nuclear RNA (snRNA) genes, is essential for their transcription. We previously reported the puriﬁcation of human PTF, a complex of four subunits, and the molecular cloning and characterization of PTF (cid:103) and (cid:100) subunits. Here we describe the isolation and expression of a cDNA encoding PTF (cid:98) , as well as functional studies using anti-PTF (cid:98) antibodies. Native PTF (cid:98) , in either protein fractions or a PTF–Oct-1–DNA complex, can be recognized by polyclonal antibodies raised against recombinant PTF (cid:98) . Immunodepletion studies show that PTF (cid:98) is required for transcription of both classes of snRNA genes in vitro. In addition, immunoprecipitation analyses demonstrate that substantial and similar molar amounts of TATA-binding protein (TBP) and TFIIIB90 can weakly associate with PTF at low salt conditions, but this association is dramatically reduced at high salt concentra- tions. Along with our previous demonstration of both physical interactions between PTF (cid:103) /PTF (cid:100) and TBP and the involvement of TFIIIB90 in the transcription of class III snRNA genes, these results are consistent with the notion that a TBP-containing substantial (and stoichiometric) TFIIIB90 PTF low-salt (100 conditions in associa- tions a free form TFIIIB90-containing free
in Computer Science and Software Engineering A Survey of the use of Genetic Algorithms in Structural Testing

— This is a survey paper of the user of Genetic Algorithms in Structural Testing. Structural testing like statement coverage or branch coverage can be automated through a variety of algorithms. Genetic Algorithms can be very useful in discovering test cases and test data to implement structural testing. A variety of algorithms are described in different categories of structural testing.
A cluster of 11 CBFtranscription factors is located at the frost tolerance locus Fr-A m 2in Triticummonococcum

Due to the adverse eﬀects of cold temperatures on winter wheat, frost tolerance is an important trait for breeding programs in regions with severe winters. Frost tolerance locus Fr-A m 2 was recently discovered in diploid wheat ( Triticum monococcum L.). This locus was mapped as a QTL on chromosome 5A m in the same region as a QTL for the level of transcription of the cold-regulated gene COR14b at 15 (cid:2) C. A CBF transcription factor was mapped in the center of these two overlapping QTLs. However, since the CBF gene family in wheat has numerous members, it was possible that multiple CBF genes were present at Fr-A m 2 . To inves-tigate this possibility we initiated a systematic characterization of the CBF family in T. monococcum . Here we report the molecular characterization of thirteen TmCBF genes. Nine of them were numbered according to the closest barley HvCBF gene, and the other four that have no clear barley orthologues were assigned numbers TmCBF15 to TmCBF18 . TmCBF5 and TmCBF18 were mapped on T. monococcum chromosomes 7A m and 6A m , respectively, and are thus not candidates for the Fr-A m 2 gene. The remaining eleven TmCBF genes are clustered at the Fr-A m 2 locus within ﬁve diﬀerent Bacterial Artiﬁcial Chromosome (BAC) clones. These BACs were mapped using a high-density map and recombination events were found between most BACs. Lines carrying these recombination events will be useful to identify which of the CBF genes is responsible for the diﬀerences in frost tolerance between the T. monococcum parental lines at the Fr-A m 2 locus.