Miracle-dz/UniFAR-FTUs huggingface dataset:
Comparative efficacy of various exercise interventions on sleep in patients with cognitive impairment: a systematic review and meta-analysis

Background Sleep disturbances are an early indicator of cognitive impairment and exacerbate its progression. While pharmacological treatments for sleep disorders exist, their side-effect profile includes an increased risk of falls and the potential to exacerbate cognitive impairment. Non-pharmacological treatments such as physical exercise should be considered. However, uncertainties persist. We aimed to assess the potential benefits of exercise interventions on sleep in patients with cognitive impairment and determine the specific effects of various exercise modalities. Materials and methods A systematic search was performed on seven databases for eligible studies published before Nov 2022. Randomized controlled trials of exercise for patients with cognitive impairment (mild cognitive impairment and Alzheimer’s disease) were included. All analyses were conducted using RevMan version 5.4. Meta-analysis and The Grading of Recommendations Assessment Development and Evaluations (GRADE) quality ratings were performed on sleep quality and objective sleep data. Results A total of 8 randomized controlled trials were included with a sample size of 486 subjects. For patients with cognitive impairment, physical exercise had a beneficial effect on sleep quality [MD = −3.55 (−5.57, −1.32), Z = 3.13, p = 0.002] and total sleep time [MD = 33.77 (23.92, 43.62), Z = 6.72, P < 0.00001]. No improvement was found in sleep efficiency and nocturnal awakening time. Subgroup analysis showed that multi-component exercise produced superior results. Conclusion Physical exercise may improve sleep quality and total sleep time for patients with cognitive impairment. Multi-component exercise designed individually is more effective. Large-scale randomized controlled trials with objective sleep outcome measurements are warranted. Clinical trial registration: https://www.crd. york.ac. uk/prospero/, identifier: CRD42022377221.
The Influence of GHRM and Organizational Culture on Environmentally Friendly Companies

The purpose of this study is to analyze the role of organizational commitment as mediating the influence of GHRM & organizational culture on Eco Friendly at Dishub Boyolali. This research method is quantitative. The population in the study were employees of the Boyolali Regency Transportation Office. In sampling this study using non-probability sampling method with purposive sampling. The number of samples of this study were 100 respondents. The data analysis method uses SMART PLS. The results of this study are that GHRM has a negative and insignificant effect on Eco-Friendly at the Boyolali Transportation Office. Organizational Culture has a positive and significant effect on ECO Friendly at the Boyolali Transportation Agency. GHRM has a positive and significant effect on organizational commitment at the Boyolali Transportation Agency. Organizational culture has a positive and significant effect on organizational commitment at the Boyolali Transportation Agency. Organizational commitment has a negative and insignificant effect on mediating the effect of GHRM on eco-friendly. Organizational commitment mediates organizational culture on eco-friendly negatively and insignificantly.
Reducing Anxiety and Enhancing Mindfulness in College Students during COVID-19 through WeActive and WeMindful Interventions

Objective: The purpose of this study was to examine the immediate and short-term, sustained effects of two virtual interventions, WeActive, an aerobic and resistance training program, and WeMindful, a mindful exercise, in reducing anxiety and improving mindfulness among college students during the COVID-19 pandemic. Methods: Participants were 60 students from a large Midwestern university who were randomly assigned to either the WeActive group (n = 36) or the WeMindful group (n = 24). The WeActive group participated in two virtual 30 min aerobic and resistance training sessions per week (WeActive) and the WeMindful group participated in two virtual 30 min mindful exercise sessions per week for eight weeks. All participants completed the Generalized Anxiety Disorder scale and the Five Facet Mindfulness Questionnaire through Qualtrics at three time points: one week prior to (pre-test), one week after (post-test), and six weeks after (follow-up) the intervention. Results: A repeated-measures ANOVA revealed a significant main effect of time on anxiety (F = 7.51, η2 = 0.036, p = 0.001) in both groups. WeActive significantly decreased anxiety scores between the pre-test and follow-up (t = 2.7, p = 0.027) and post-test and follow-up (t = 3.1, p = 0.007), and WeMindful significantly decreased anxiety scores between the post-test and follow-up (t = 0.641, p = 0.028). For mindfulness, there was a significant main effect of time in both groups (F = 3.91, η2 = 0.009, p = 0.025), where only WeMindful significantly increased mindfulness from the pre-test to follow-up (t = −2.7, p = 0.025). Conclusions: Anxiety decreased significantly in both the WeActive and WeMindful groups and mindfulness increased significantly in the WeMindful group. Furthermore, the decrease in anxiety was sustained in a short-term period following the end of the intervention.
Interacting with Obstacles Using a Bio-Inspired, Flexible, Underactuated Multilink Manipulator

With the increasing demand for robotic manipulators to operate in complex environments, it is important to develop designs that work in obstacle-rich environments and can navigate around obstacles. This paper aims to demonstrate the capabilities of a bio-inspired, underactuated multilink manipulator in environments with fixed and/or movable obstacles. To simplify the system design, a single rotational actuator is used at the base of the manipulator. We present a modeling method for flexible, multilink underactuated manipulators, including their interaction with obstacles. We also demonstrate how to plan a trajectory for the manipulator in environments with fixed obstacles. The robustness of the manipulator is examined by analyzing the effects of uncertainty in its initial state and the position of obstacles. Next, we demonstrate the performance of the manipulator in environments with movable obstacles and show the advantages of controlling the obstacles’ radii and positions. Lastly, we showcase the process of picking up an object in workspaces with obstacles. All the findings are supported by simulations as well as hardware experiments.
Efficient and Accurate Indoor Positioning System: A Hybrid Approach Integrating PCA, WKNN, and Linear Regression

—The high-precision Indoor Positioning System (IPS) is a captivating area of research that has made significant advancements in recent years due to the increasing demand for its applications. Our study proposes an innovative approach to improve indoor positioning accuracy by integrating Principal Component Analysis (PCA), weighted k-nearest Neighbors (WKNN), and Linear Regression (PCA-WLR). This hybrid strategy enables the system to leverage the unique characteristics of each model, capturing intricate patterns and correlations in the data. Experimental evaluations on a publicly available dataset demonstrate the superiority of our hybrid approach. The Root Mean Squared Error (RMSE) achieved is 1.97 meters, and the mean distance error is 2.23 meters. Remarkably, the ensemble outperforms individual methods in other studies on the same dataset, showing 10.8% to 17.2% improvement in accuracy. Notably, our proposed hybrid approach significantly reduces training time from 581.3599 seconds to 8.8814 seconds, representing an impressive reduction of approximately 98.47%. Similarly, testing time is reduced from 10.1721 seconds to 0.0176 seconds, indicating a substantial decrease of around 99.82%. These significant reductions in training and testing times underscore the efficiency and effectiveness of our proposed ensemble model, making it highly practical for real-time applications.
The Effectiveness of an Education Intervention based on Self-Care Model on Depressive Symptoms among adolescents with Type 1 Diabetes Mellitus

Introduction: Over the past years, evidence has shown a high prevalence of depression among Type 1 Diabetes Mellitus (T1DM) patients. This interventional study was performed to decrease depressive symptoms using education based on the self-care model in Kiambu County, Kenya. Methodology: The study was conducted from January to August 2021 at diabetic clinics of Thika Level 5 Hospital (TL5H) and Kiambu Level 5 Hospital (KL5H). The study employed a pre-test post-test non-equivalent quasi-experimental study design. There were 96 adolescents with T1DM obtained by stratified random sampling, and assigned into experimental (48 respondents) and control group (48 respondents). Depressive symptoms were evaluated in the first and seventh months using the Center for Epidemiology Studies Short Depression (CES-D) scale. Paired sample T-test and Independent sample T-test were used to analyze data. Results: The results of the Independent sample T-test showed that there was a statistically significant difference in the mean score difference of depressive symptoms at postintervention (t = -2.968, df = 94, p = 0.004), but no statistically significant difference in the mean score difference of depressive symptoms at baseline (t = -1.100, df = 86, p =0.274). The result of the paired sample T-test revealed that there was a statistically significant difference in the mean score difference of depressive symptoms in the intervention group (t = -4.374, df = 47, p = <0.001), but no statistically significant difference in the mean score difference of depressive symptoms in the control group (t= -1.304, df = 47, p =0.199). Conclusions: Education intervention based on the self-care model is an effective program that can improve depressive symptoms. In addition, the education intervention based on the self-care model needs to be implemented continuously to prevent diabetes-related complications and improve depressive symptoms among diabetic patients.
Identification, Expression and Antimicrobial Functional Analysis of Interleukin-8 (IL-8) in Response to Streptococcus iniae and Flavobacterium covae in Asian Seabass (Lates calcarifer Bloch, 1790)

Simple Summary As a proinflammatory cytokine, interleukin-8 (IL-8) plays a crucial function in inflammatory responses by recruiting and regulating monocytes and lymphocytes during the early stages of inflammation. In this study, a cDNA encoding the Asian seabass (Lates calcarifer) IL-8 gene was cloned and referred to as LcIL-8. Moreover, the expression levels of LcIL-8 in various tissues of normal and diseased fish were analyzed by means of qRT–PCR. Additionally, the recombinant LcIL-8 protein (rLcIL-8) was overexpressed in the Escherichia coli system, and its biological functions under various conditions were investigated. LcIL-8 transcripts were expressed in all the tested tissues of normal Asian seabass. The constitutive mRNA expression of LcIL-8 was quantified in six tissues of fish infected with virulent Streptococcus iniae and Flavobacterium covae at three different concentrations. The minimum inhibitory concentration (MIC) and therapeutic effects of the rLcIL-8 protein against S. iniae were also thoroughly investigated. The obtained findings could be used to further develop prophylactic or therapeutic strategies applicable to the Asian seabass farming industry. Abstract In this research, the proinflammatory cytokine interleukin-8 (IL-8) was shown to play a key role in inflammatory responses in fish. This study involved the cloning of the gene that encodes IL-8 in Asian seabass (Lates calcarifer) as well as analyses of its expression and function in this fish. The expression levels of LcIL-8 indicated that it was broadly expressed in most analyzed tissues, with the most predominant expression in the whole blood 6 to 24 h after infection with S. iniae at concentrations of 105 colony-forming units (CFU)/fish (p < 0.05). After fish were immersed in F. covae, the LcIL-8 transcript was upregulated in the gills, liver and intestine, and the highest expression level was observed in the gills. However, LcIL-8 was downregulated in all the tested tissues at 48 and 96 h after infection with the two pathogenic strains, indicating that Lc-IL8 has a short half-life during the early immune responses to pathogens. Moreover, the MIC of the rLcIL-8 protein against S. iniae was 10.42 ± 3.61 µg/mL. Furthermore, functional analyses clearly demonstrated that 10 and 100 µg of the rLcIL-8 protein efficiently enhanced the phagocytic activity of Asian seabass phagocytes in vitro (p < 0.05). Additionally, in vivo injection of S. iniae following the rLcIL-8 protein indicated that 50 and 100 µg of rLc-IL-8 were highly effective in protecting fish from this pathogen (p < 0.001). The obtained results demonstrate that rLcIL-8 possesses a biological function in the defense against bacterial infections in Asian seabass.
Mise au point d'un inoculant biologique pour le blé irrigué du Mali

Because of the high price of imported P-fertilizers in Mali, the Tilemsi rock phosphate (TRP) is a cheaper locally available P source alternative for farmers. In many areas regardless of its good physical and chemical characteristics, crops and particularly wheat showed very slow response to TRP. With the broad aim of biologically improving P uptake by wheat, in this work we describe the use of TRP solubilizing microorganisms in field inoculation trials. In 3 different Malian wheat cultivars, 4 to 12% of the rhizosphere microorganisms were able to dissolve TRP. Six bacterial and two fungal isolates were selected for their high P-solubilizing activity in solid and liquid media, and were tested in a field in Koygour (Diré) in 2000-2001. Two fungal isolates Aspergillus niger (C1) and Penicillium chrysogenum (C13) and Pseudomonas sp. (BR2) significantly increased plant heights after 60 days, and the fresh and dry matter yields and P-uptake after 90 days of growth. Field assays were performed in Koygour (Diré) in 2001-2002. Inoculation treatments included C1, C13, BR2, C1+BR2, C13BR2, and a control in the presence or absence of the AM fungus Glomus intraradices. P treatments included Tilemsi rock phosphate (TRP), phosphate biammoniacal (DAP) and an unfertilized control. The colonization of wheat root with AM was significantly higher following inoculation with G. intraradices, and when TRP was the P source used. The presence of Pseudomonas strain (BR2) improved root colonization by the AM fungus. In general, straw and grain yield improved significantly following inoculation with AM and phosphate solubilizing microorganisms. The highest P concentration in wheat grain and straw was recorded in treatment including a combinaison of AM, BR2 and C1 in the presence of TRP.
Ossicular joint histopathology in cases of age‐related hearing loss

Abstract Objectives Age‐related hearing loss (presbycusis) is a prevalent condition traditionally attributed to inner ear dysfunction. Little is known about age‐related changes in the ossicular joints or their contribution to presbycusis. Herein, we performed an otopathologic evaluation of the ossicular joints in cases of presbycusis without a clear sensorineural explanation. Methods Histopathologic analysis of the incudomallear (IM) and incudostapedial (IS) joints was performed in specimens from the National Temporal Bone Registry with audiometrically confirmed presbycusis but without histologically observed sensorineural, strial, or mixed features; deemed cases of “indeterminate” presbycusis. Specimens identified as “indeterminate” presbycusis (IP, n = 18) were compared to specimens with histologically confirmed sensorineural presbycusis (n = 16) and strial presbycusis (n = 11). Presbycutic specimens were also compared to age‐matched controls (n = 9) and young controls (n = 14). Results The synovial space at the center of the IM joint was wider in the IP group (194 ± 36.8 μm) compared to age‐matched controls (138 ± 36.5 μm), young controls (149 ± 32.2 μm), and ears with sensorineural presbycusis (148 ± 52.7 μm) (p < .05). The synovial space within the IS joint was wider in the IP group (105 ± 33.0 μm) when compared to age‐matched controls (57.9 ± 13.1 μm) and ears with sensorineural presbycusis (62.3 ± 31.2 μm) (p < .05). Conclusion IP ears have wider IM and IS joints when compared to ears with sensorineural presbycusis and age‐matched controls. Findings point to a potential middle ear source of high frequency conductive hearing loss in a subset of presbycutic ears. Level of Evidence Retrospective study.
Molecular and anatomical analyses reveal that Peronia verruculata (Gastropoda: Onchidiidae) is a cryptic species complex

Recent years have seen an increase in the number of studies that use DNA sequence information in addition to morphological methods, as the latter alone can be inadequate for morphologically similar, cryptic species. Marine onchidiid slugs (Mollusca: Gastropoda: Onchidiidae), which commonly inhabit intertidal environments and have a near-global distribution, comprise 11 genera and 86 described species. Singapore has 19 recorded species of onchidiids with Peronia verruculata (Cuvier, 1830) being the most abundant. Here we present mitochondrial DNA sequence data from 63 P. verruculata-like specimens to show that they constitute two closely-related clades with distinct sequence signatures and a clear barcode gap. Intraclade distances are 0–1.8% while interclade distances range from 4.7 to 6.0%. Scanning electron microscopy of internal copulation organs reveals that the two clades have distinct penial and accessory gland spine structures, which also differ in size. Using an integrative taxonomic approach, we propose that what was initially thought to be P. verruculata in Singapore, actually are two different species of Peronia.
Personalized Approach to Chronic Antibiotic-Refractory Pouchitis: A Case Report and Review of the Literature

Patients who undergo restorative proctocolectomy and ileoanal anastomosis can develop pouchitis as a common chronic complication. A rare subset of patients fails to respond to multiple antibiotic therapies and develop chronic antibiotic-refractory pouchitis (CARP). We present a case of a 45-year-old male with pouchitis refractory to chronic antibiotic therapy and histology demonstrating chronic inflammatory changes. Management involved mesalamine and probiotics, resulting in a positive clinical response and symptom absence on follow-up. This case highlights the intricacies of treating chronic pouchitis post ileoanal anastomosis, showcasing the efficacy of a personalized approach using mesalamine and probiotics. CARP is emerging as an entity associated with poor quality of life and increased healthcare costs. CARP fails to respond to multiple courses of antibiotic therapy. Therefore, the management of CARP is difficult and limited. Current literature on the management of CARP is scarce and mainly involves immunomodulatory therapy and probiotics. It is essential to keep this differential diagnosis in mind in patients with recurrent pouchitis episodes and start them on immunomodulator treatment and probiotics rather than repeated courses of antibiotics.
RNF213 inhibits migration via mediating KRT16 ubiquitination in lung adenocarcinoma cell

Background Non-small cell lung cancer (NSCLC) is one of the most common malignant tumors, and lung adenocarcinoma (LUAD) accounts for 40% of NSCLC. Ring �nger protein 213(RNF213) has been shown to inhibit the progression of many different cancers including glioblastoma and breast cancer. However, the role of RNF213 in LUAD has not been reported. The aim of this study was to investigate the effect of RNF213 on the progression of LUAD. Methods The expression of RNF213 in LUAD tissues was analyzed by western blot, TCGA (The Cancer Genome Atlas) and GTEx (Genotype_Tissue Expression Project) databases. Kaplan-Meier Plotter database was used to predict the clinical signi�cance of RNF213 in LUAD. We determined the role of RNF213 in LUAD cell lines through CCK-8 assay, migration and invasion assay. The relationship of RNF213 and KRT16 were demonstrated via co-immunoprecipitation, ubiquitination, protein degradation assay and immunoblotting. We next con�rmed the oncogenetic role of KRT16 using migration and rescue assay. The clinical roles of RNF213 and KRT16 were explored by immunohistochemical staining assay (IHC) and Kaplan-Meier survival analysis.
Interrelate Training and Clustering for Online Speaker Diarization

In clustering-based speaker diarization systems, the embedding clusters for distinctive speakers exhibit wide variability in size and density, posing difficulty for clustering accuracy. In spite of this, with the assistance of the overall distance relationships among speaker embeddings, most of the embeddings can be grouped to the correct cluster by sophisticated offline clustering algorithms. However, in online scenarios, such a complete distance relationships of the embeddings can not be obtained due to the incremental arrival of embeddings. Consequently, determining the number of clusters and then correctly grouping the embeddings become challenging in an online fashion. Furthermore, errors would accumulate quickly over time if the online clustering algorithm assigns the embeddings into clusters erroneously in the beginning. To address these problems, we designed a novel framework for online clustering. To reduce the high variability of speaker embeddings, we proposed the clustering guided embedding extractor training (CGEET) algorithm to encourage similarity between the size of the embedding space for different speakers in attempt to simplify the distance relationships of embeddings. The CGEET algorithm can grasp the distance information of the entire speaker embedding space and provide it to the online clustering algorithm. With this preliminary information, the distance thresholds guided online clustering (DTGOC) algorithm then processes incoming embeddings using a divide-and-conquer approach. It first handles the embeddings with explicit distance relationships and then searches for possible path combination they have with remaining embeddings in an online fashion. Moreover, in order to utilize the distance relationships of embeddings that are far apart in time, an online re-clustering strategy is incorporated in our DTGOC algorithm, which can alleviate error accumulation during online clustering. By implementing the above innovations, our proposed online clustering system achieves 14.00% DER with collar 0.25 at 2.5 s latency on the AISHELL-4, while the DER of the offline agglomerative hierarchical clustering system is 14.54%.