Miracle-dz/UniFAR-FTUs huggingface dataset:
Open Conjunctival Approach for Sub-Tenon’s Xen Gel Stent Placement and Bleb Morphology by Anterior Segment Optical Coherence Tomography

Précis: Sub-Tenon’s implantation of the Xen Gel stent resulted in significant intraocular pressure (IOP) lowering along with a low rate of postoperative bleb needling, and a favorable bleb morphology on anterior segment optical coherence tomography (AS-OCT). Purpose: The aim was to assess clinical outcomes and bleb morphology following sub-Tenon’s implantation of the Xen Gel Stent. Methods: The medical records of patients who underwent sub-Tenon’s Xen Gel Stent implantation with intraoperative mitomycin-C through an open conjunctival approach were reviewed. Postoperative IOP and number of glaucoma medications at 1, 3, 6, 9, and 12 months were assessed. Bleb morphology was analyzed at various timepoints using AS-OCT (Topcon DRI OCT version 1.1.1). Results: Twenty-six eyes were included in the study. Mean age was 69.4±8.0 years. Mean preoperative IOP was 28.1±7.8 mm Hg on an average of 3.5±0.9 glaucoma medications. Mean IOP at postoperative month 12 (n=23 eyes) was 12.9±4.0 mm Hg (P<0.01) on an average of 0.3±0.6 (P<0.01) glaucoma medications. Three eyes (12%) required postoperative needle revision. Bleb morphology in the early postoperative period (≤3 mo) was characterized by multiple small subconjunctival microcysts on AS-OCT. At the intermediate (6 to 12 mo) and long-term (>12 mo) timepoints, reduction in microcysts with multiple internal parallel layers of aqueous flow and a uniform pattern were more frequently noted. All functional blebs were characterized by the presence of a posterior episcleral fluid lake. Failed blebs showed absence of aqueous humor around the distal end of the microshunt. Conclusion: Following an open conjunctival approach, sub-Tenon’s placement of the Xen Gel Stent with significant IOP lowering was achieved. In eyes with good shunt function, bleb morphology by AS-OCT showed a posterior episcleral fluid lake similar to findings following trabeculectomy.
Severe Acute Respiratory Syndrome Coronavirus 2 Transmission in Georgia, USA, February 1–July 13, 2020

The serial interval and effective reproduction number for coronavirus disease (COVID-19) are heterogenous, varying by demographic characteristics, region, and period. During February 1–July 13, 2020, we identified 4,080 transmission pairs in Georgia, USA, by using contact tracing information from COVID-19 cases reported to the Georgia Department of Public Health. We examined how various transmission characteristics were affected by symptoms, demographics, and period (during shelter-in-place and after subsequent reopening) and estimated the time course of reproduction numbers for all 159 Georgia counties. Transmission varied by time and place but also by persons’ sex and race. The mean serial interval decreased from 5.97 days in February–April to 4.40 days in June–July. Younger adults (20–50 years of age) were involved in most transmission events occurring during or after reopening. The shelter-in-place period was not long enough to prevent sustained virus transmission in densely populated urban areas connected by major transportation links.
Risk factors for HIV virological non‐suppression among adolescents with common mental disorder symptoms in Zimbabwe: a cross‐sectional study

Adolescents are at increased risk of HIV virological non‐suppression compared to adults and younger children. Common mental disorders such as anxiety and depression are a barrier to adherence and virological suppression. The aim of this study was to identify factors associated with virological non‐suppression among adolescents living with HIV (ALWH) in Zimbabwe who had symptoms of common mental disorders.
Oryza sativa as a Tool for Assessing Arsenic Efficacy of Arsenic Remediation of Agricultural Soils by Sulfidated Zerovalent Iron Nanoparticles

Arsenic (As) is highly toxic in its inorganic form. It is naturally presented at elevated levels in the groundwater of a number of countries and contaminates drinking water sources, generating numerous health and environmental problems. Current methodologies for its remediation have deficiencies which fuel the constant exploration of new alternatives. Therefore, the development of robust methodologies for the evaluation of potential remediation technologies are not only timely but also highly needed. In this study we have investigated the use of a rice plant species as a means to evaluate the efficacy of As remediation using sulfidated zerovalent iron nanoparticles (S-nZVI). The obtained results show that addition of S-nZVI to soils had a beneficial impact to plant growth in the presence of As(V) and As(III) concentrations between 10 and 50 ppm. Positive effects were also found for plant biomass and chlorophyll content in the plants. Moreover, evaluation of As uptake by plants showed that the application of S-nZVI reduced the amount of both As(V) and As(III) in shoots and increased the amount of As in the roots. Studies on the Fe and P content in shoot and root after exposure to As with and without the nanoparticles demonstrated that nanoparticles remain mainly in the roots and that P uptake by plants was not significantly affected, suggesting that S-nZVI treatment is safe for plants at the assayed doses. These results overall confirm the method as robust and reliable for demonstrating the reduction of the bioavailability of As in soil by S-nZVI sequestration.
Improving delirium detection in intensive care units: Multicomponent education and training program

Delirium is a common, devastating, and underrecognized syndrome in the intensive care unit (ICU). The study aimed to describe and evaluate a multicomponent education and training program utilizing a “Train‐The‐Trainer” (TTT) model, to improve delirium detection across a large health system.
The Impact of TiO 2 Nanoparticle Exposure on Transmembrane Cholesterol Transport and Enhanced Bacterial Infectivity

We have previously shown that exposure to TiO2 nanoparticles (NPs) reduces the resistance of HeLa cells to bacterial infection. Here we demonstrate that the increased infectivity is associated with enhanced asymmetry in the cholesterol distribution. We applied a new live cell imaging method which uses tunable orthogonal cholesterol sensors to visualize and quantify in-situ cholesterol distribution between the two leaflets of the plasma membrane (PM). In the control culture, we found marked transbilayer asymmetry of cholesterol, with the concentration in the outer plasma membrane (OPM) being 13 ± 2-fold higher than that in the inner plasma membrane (IPM). Exposure of the culture to 0.1 mg/mL of rutile TiO2 NPs increased the asymmetry such that the concentration in the OPM was 51 ± 10 times higher, while the total cholesterol content increased only 21 ± 2 percent. This change in cholesterol gradient may explain the increase in bacterial infectivity in HeLa cells exposed to TiO2 NPs since many pathogens, including Staphylococcus aureus used in the present study, require cholesterol for proper membrane attachment and virulence. RT-PCR indicated that exposure to TiO2 was responsible for upregulation of the ABCA1 and ABCG1 mRNAs, which are responsible for the production of the cholesterol transporter proteins that facilitate cholesterol transport across cellular membranes. This was confirmed by the observation of an overall decrease in bacterial infection in ABCA1 knockout or methyl-β-cyclodextrin-treated HeLa cells, as regardless of TiO2 NP exposure. Hence rather than preventing bacterial infection, TiO2 nanoparticles upregulate genes associated with membrane cholesterol production and distribution, hence increasing infectivity.
A novel physical unclonable function (PUF) using 16 × 16 pure-HfO x ferroelectric tunnel junction array for security applications

As the computing paradigm has shifted toward edge computing, improving the security of edge devices is attracting significant attention. However, because edge devices have limited resources in terms of power and area, it is difficult to apply a conventional cryptography system to protect them. On the other hand, as a simple security application, a physical unclonable function (PUF) can be implemented without power and area problems because it provides a security key by utilizing process variations without additional external circuits. Ferroelectric tunnel junctions (FTJs) are 2-terminal devices that store information by changing the resistance of a ferroelectric material, where the resistance is determined by the polarization states of the ferroelectric domains. Because polycrystalline ferroelectric materials have a multi-domain nature, domain variation can also be used as a randomness source to induce cell-to-cell variations along with process variations. In this paper, we demonstrate PUF operations of a low-power, small area 16 × 16 hafnium oxide (pure-HfO x )-based FTJ array using certain metrics. It is clear that the proposed array consisting of scaled FTJs has adequate randomness for security applications such that the array-level PUF operations are robust against model-based machine learning attacks.
The present and future of intrapartum computerized cardiotocography: role of pattern recognition incorporating single vs. multiple parameters

Abstract Computer assisted cardiotocography holds a great promise in minimizing human errors thereby improving perinatal outcome. Despite exponential growth (Moore’s law) in computing power for decades, this promise remains unrealized. The systematic analyses of studies on computerized cardiotocography offer little guide to future. This analytical review presents a more qualitative discussion of available evidence as well as concepts regarding the development and acceptance of computerized cardiotocography. To begin with, a workable approach would be for computer algorithms to follow the most scientific visual cardiotocography interpretation frameworks incorporating multiple fetal heart rate parameters and uterine contractions. This ability could be studied and form the basis for regulation of computer algorithms. Addition of background risk factors would be another step. This may take form of familiar multi-tier systems or new alternative strategies like the fetal reserve index. “Machine learning” will remain challenging because of complex variability in fetal-maternal conditions, labor characteristics and clinical intervention changing the outcomes. Randomized controlled trials of adequate size may remain very rare. However, prospective and retrospective testing of computer algorithms with careful qualitative and comparative approach would help clinicians and hospital managers in their decisions. Singular parameters like the popular “deceleration area” and “deceleration capacity” have poor predictive value for fetal acidemia or hypoxic injury. Scientific pattern-recognition of important fetal heart rate parameters like decelerations seems crucial for visual as well as computerized cardiotocography. Success of computerizedcardiotocography depends on team effort by the obstetricians with in-depth practical knowledge/experience and skilled artificial intelligence (AI) specialists.
Direct, indirect and total effect of HIV coinfection on the risk of non‐liver‐related cancer in hepatitis C virus‐infected patients treated by direct‐acting antivirals: a mediation analysis

HIV‐coinfected patients experience higher incidences of non‐liver‐related cancers than HCV‐monoinfected patients. Chronic inflammation, immunosuppression, but also higher tobacco or alcohol consumption and metabolic dysregulation could explain this higher risk. We aimed to estimate the direct, indirect and total effects of HIV coinfection on the risk of non‐liver‐related cancers in HCV participants treated with direct‐acting antivirals (DAAs).
Pilot study of functional circuit exercise in older adults

ABSTRACT Sustainable exercise strategies are needed for older adults to maintain aerobic capacity and strength. The objective of this pilot in 6 adults ≥ 65 years of age was to determine the feasibility and preliminary efficacy of high-intensity functional circuit training which does not require stationary equipment. Instructor-led small group exercise classes were held 3x/week for 12 weeks using weight-bearing exercises performed in a circuit format at ratings of perceived exertion (RPE) of 6–8/10. All 6 participants completed the pilot and showed significant improvements by the Wilcoxon signed-rank test. The six-minute walk distance increased 10.5%. Timed arm curl and chair stands increased 26.8% and 30.3% (all p ≤ 0.03). These preliminary findings suggest that high-intensity functional circuit exercise is feasible in older adults and increases functional measures of aerobic capacity and strength. Further research is warranted to develop this strategy which has the potential for broad dissemination without the need for a traditional exercise facility.
Active targeted dual-modal CT/MR imaging of VX2 tumors using PEGylated BaGdF5 nanoparticles conjugated with RGD

Multimodal imaging can improve the accuracy of cancer diagnosis by combining two or more imaging modalities into one system. In this study, PEGylated BaGdF5 nanoparticles (NPs) were synthesized by a hydrothermal method, and the formed PEG-BaGdF5 NPs showed good X-ray attenuation properties and positive MR contrast effects in vitro. Considering that the overexpression of integrin αvβ3 in the endothelial cells of angiogenic tumor vasculature is universal, RGD peptide, which can recognize and bind integrin αvβ3 specifically, was connected to the surface of PEG-BaGdF5 NPs. The resulting RGD-PEG-BaGdF5 NPs had good biocompatibility and a long half-life in vivo. In VX2 tumor-bearing mice, the HU values and MR signal enhancement of tumor sites in the targeted group were both higher than that in the non-targeted group after intravenous injection of RGD-PEG-BaGdF5 NPs or PEG-BaGdF5 NPs, respectively. Therefore, the RGD-PEG-BaGdF5 NPs may be used as dual-modal CT/MR contrast agents of different types of solid tumors via an active RGD-mediated vasculature targeting pathway.
Predicting brain function status changes in critically ill patients via Machine learning

OBJECTIVE In intensive care units (ICUs), a patient's brain function status can shift from a state of acute brain dysfunction (ABD) to one that is ABD-free and vice versa, which is challenging to forecast and, in turn, hampers the allocation of hospital resources. We aim to develop a machine learning model to predict next-day brain function status changes. MATERIALS AND METHODS Using multicenter prospective adult cohorts involving medical and surgical ICU patients from 2 civilian and 3 Veteran Affairs hospitals, we trained and externally validated a light gradient boosting machine to predict brain function status changes. We compared the performances of the boosting model against state-of-the-art models-an ABD predictive model and its variants. We applied Shapley additive explanations to identify influential factors to develop a compact model. RESULTS There were 1026 critically ill patients without evidence of prior major dementia, or structural brain diseases, from whom 12 295 daily transitions (ABD: 5847 days; ABD-free: 6448 days) were observed. The boosting model achieved an area under the receiver-operating characteristic curve (AUROC) of 0.824 (95% confidence interval [CI], 0.821-0.827), compared with the state-of-the-art models of 0.697 (95% CI, 0.693-0.701) with P < . 001. Using 13 identified top influential factors, the compact model achieved 99.4% of the boosting model on AUROC. The boosting and the compact models demonstrated high generalizability in external validation by achieving an AUROC of 0.812 (95% CI, 0.812-0.813). CONCLUSION The inputs of the compact model are based on several simple questions that clinicians can quickly answer in practice, which demonstrates the model has direct prospective deployment potential into clinical practice, aiding in critical hospital resource allocation.
Leptin receptor expression in GABAergic cells is not sufficient to normalize metabolism and reproduction in mice.

Previous studies indicate that leptin receptor (LepR) expression in GABAergic neurons is necessary for the biological effects of leptin. However, it is not clear whether LepR expression only in GABAergic neurons is sufficient to prevent the metabolic and neuroendocrine imbalances caused by LepR deficiency. In the present study, we produced mice that express the LepR exclusively in GABAergic cells (LepR VGAT mice) and compared them to wild-type (LepR +/+) and LepR-deficient (LepR Null/Null) mice. Although LepR VGAT mice showed a pronounced reduction in body weight and fat mass, as compared to LepR Null/Null mice, male and female LepR VGAT mice exhibited an obese phenotype in comparison to LepR +/+ mice. Food intake was normalized in LepR VGAT mice; however, LepR VGAT mice still exhibited lower energy expenditure in both sexes and reduced ambulatory activity in the females, compared to LepR +/+ mice. The acute anorexigenic effect of leptin and hedonic feeding were normalized in LepR VGAT mice despite the hyperleptinemia they present. Although LepR VGAT mice showed improved glucose homeostasis, as compared to LepR Null/Null mice, both male and female LepR VGAT mice exhibited insulin resistance. In contrast, LepR expression only in GABAergic cells was sufficient to normalize the density of AgRP and α-MSH immunoreactive fibers in the paraventricular nucleus of the hypothalamus. However, LepR VGAT mice exhibited reproductive dysfunctions, including subfertility in males and alterations in the estrous cycle of females. Taken together, our findings indicate that LepR expression in GABAergic cells, although critical to the physiology of leptin, is insufficient to normalize several metabolic aspects and the reproductive function in mice.
Medicinal Cannabis in Children and Adolescents with Autism Spectrum Disorder: A Scoping Review.

BACKGROUND Autism spectrum disorder (ASD) is a neurodevelopmental condition estimated to affect 1 in 66 children in Canada, and 1 in 270 individuals worldwide. As effective therapies for the management of ASD core and associated symptoms are limited, parents are increasingly turning to clinicians for advice regarding the use of medicinal cannabis to manage behavioural disturbances. OBJECTIVE The objective of this scoping review was to identify and map symptoms, outcomes and adverse events related to medicinal cannabis treatment for ASD-related behaviours. METHODS Ovid MEDLINE, Embase, CINAHL, PsycInfo, Web of Science Core Collection, Google Scholar, and grey literature sources were searched up to January 5, 2020 for studies. Included studies met the following criteria: 1) investigate the use of medicinal cannabis, 2) at least 50% participants had ASD, 3) at least 50% of the study population was 0-18 years old, and 4) any study design (published or unpublished). RESULTS We identified eight completed and five ongoing studies meeting the inclusion criteria. All studies reported substantial behaviour and symptom improvement on medicinal cannabis, with 61-93% of subjects showing benefit. In the three studies reporting on concomitant psychotropic medication usage and with cannabis use, up to 80% of participants observed a reduction in concurrent medication use. Adverse events related to cannabis use were reported in up to 27% of participants related, and two participants had psychotic events. CONCLUSIONS Early reports regarding medicinal cannabis in pediatric ASD symptom management are presented as positive; the evidence, however, is limited to very few retrospective cohort and observational studies. Evidence of safety and efficacy from prospective clinical trials is needed.
Does the Fear of Missing Out Moderate the Relationship Between Social Networking Use and Affect? A Daily Diary Study

Social networking site (SNS) use is common and speculation about the negative impact of SNS use on mental health and psychological well-being is a recurring theme in scientific debates. The evidence for this link, however, is inconclusive. The Fear of Missing Out (FoMO) may assist in understanding the mixed evidence, as individuals who experience FoMO are more driven to keep up with what is happening to avoid missing out. We used a 2-week daily diary study of 408 university students to measure the daily associations between SNS use and negative and positive affect and whether FoMO moderated these associations. Multi-level Bayesian regression analyses revealed that 1) greater SNS use was associated with reductions in successive positive affect, but not increases in negative affect and 2) FoMO moderated the influence of SNS use such that increases in successive negative affect occurred only in those individuals high in trait FoMO.
Parenting stress, self‐efficacy and COVID‐19 health risks as predictors of general stress among nurses

Abstract Aim The purpose of the study was to examine the influence of parenting stress, self‐efficacy and COVID‐19 health risks on general stress among nurses in the Midwest, United States, during the pandemic. Background As frontline workers amidst the coronavirus disease 2019 (COVID‐19) pandemic, nurses have been subject to stressors at home and at work. Method This quantitative, cross‐sectional study included 896 nurses with at least one child below 18 years of age. Using purposive sampling, participants answered an online survey composed of demographic questions, perception of COVID‐19 health risks, measures of self‐efficacy, general stress and parenting stress. Bivariate correlation and multiple regression were conducted. Data were collected from July 13 to August 13, 2020. Results The four predictors, along with eight demographic covariates, accounted for 40% of the variance in general stress. Parenting stress and COVID‐19 health risks were positively related to general stress, while self‐efficacy was negatively associated with general stress. Conclusions Results highlight the negative influence of parenting stress on nurses' general stress and the importance of self‐efficacy in reducing stress. Findings suggest that support services for nurses should focus not only on work‐related stressors but also consider parenting stressors, work‐home imbalances and self‐efficacy.
Safety and efficacy of botulinum toxin type A in preventing and treating scars in animal models: A systematic review and meta‐analysis

Previous studies have used botulinum toxin type A (BTXA) to improve postoperative and hypertrophic scars; however, there is lack of detailed verification on the safety and effectiveness of this approach. This study aimed to evaluate the therapeutic effect of BTXA on postoperative hypertrophic scars and its influence on cytokine expression in animal models. A computerised search of different databases was performed, including PubMed, Web of Science, Scopus, Cochrane, Embase, CNKI, and Wanfang, up to 10 March 2021. A meta‐analysis was performed using R 4.0. 0 based on hypertrophic index, epithelialisation time, wound area, and vascular endothelial growth factor (VEGF) expression. Eleven studies were included. The meta‐analysis showed a significant difference in hypertrophic index (standardised mean difference [SMD] = −2.63, 95% confidence interval [CI]: −3.50 to −1.76, P < .01), wound area (SMD = −0.54, 95% CI: −1.24 to 0.16, P < .01), and VEGF expression (SMD = −2.56, 95% CI: −3.50 to −1.62, P < .01). This study shows that BTXA is safe and effective in preventing and treating scar hypertrophy in animal models, but excessive doses of BTXA and BTXA to treat large areas should be avoided.