Miracle-dz/UniFAR-FTUs huggingface dataset:
Chapter Impact of Clinical Pilates on Satisfaction With Life of Women With Urinary Incontinence

The high prevalence of urinary incontinence is a problem of public health due to its physical, psychological, social and economic effects. It affects predominantly all age female gender and may influ-ence satisfaction with life. Clinical Pilates has been studied in healthy subjects and seems to have positive effects on the psychological and general well-being. However, this method lacks evidence upon its effect on women with urinary incontinence. This study aims to assess the impact of a Clinical Pilates exercise-based program on the perception of contraction of pelvic floor muscles and in satisfaction with life of women with urinary incontinence. A quasi-experimental investigation has been carried out with a 60 women sample distributed by an Experimental Group (EG; n=30) and a Control Group (CG; n=30). Participants were aged ≥ 50 years, diagnosed with stress and mixed urinary incontinence, grade ≥ 3 in the Modified Oxford Grading Scale. EG performed 60 minutes classes of Clinical Pilates based exercises twice a week for ten weeks. CG had no intervention. Pelvic floor efficacy was assessed through Broome’s Self-Efficacy Scale and satisfaction with life through Satisfaction with Life Scale. Descriptive statistics and the Inferential Statistics were used. The T-Student test, the Wilcoxon and the Mann-Whitney tests were used in case of ab-normality with α = 0.05). The results showed that the Clinical Pilates exercise-based program had positive effects on the contraction of pelvic floor muscles, total score [79(10.48) vs 35.9(11.44); p < 0.001] in both Broome’s sub-scales, A [80.71(9.29) vs 35.36(18.57); p < 0.001] and B [77.6(11.06) vs 35.36(18.57); p = 0.02] and in satisfaction with life [24.00(8.00) vs 16.00 (8.00); p < 0.001]. In conclusion, Clinical Pilates
Monotone Smoothing Spline Curves Using Normalized Uniform Cubic B-splines (Special Issue on the 44th ISCIE International Symposium on Stochastic Systems Theory and Its Applications(1))

This paper considers a problem on the non-negative derivative constraints on the cubic smoothing spline curves using normalized uniform B-splines as the basis functions. In particular, we derive a condition for monotonic constraints over interval along the line of Fritsch and Carlon’s works in [1]. Moreover, we present how these results are incorporated in the optimal smoothing spline problems. The performance is examined by some numerical examples.
EVALUATION OF ANTIDEPRESSANT ACTIVITY OF ETHANOLIC EXTRACT OF OCIMUM SANCTUM (TULSI) LEAF IN WISTAR ALBINO RATS AFTER SUB-ACUTE ADMINISTRATION

Background: Allopathic antidepressants are ineffective in many patients causing treatment failure and addition of adjuvant and/or substitutions. Moreover, they have adverse effects causing decreased compliance. Hence there is potential for effective herbal alternatives with fewer adverse effects like Ocimum sanctum . Aim: To evaluate the antidepressant activity of ethanolic leaf extract of Ocimum sanctum after subacute administration. Materials and Methods: 24 wistar albino rats of either sex were randomly divided into four groups (n=6) and administered normal saline, Ocimum sanctum ethanolic extract (OSEE), Fluoxetine and OSEE + half dose Fluoxetine respectively for 30 days. Forced swim test (FST) and modified tail suspension test (TST) for depression were performed on days 1, 7, 15 and 30. Results were expressed as Mean ± SEM. One way ANOVA ( P<0.05 regarded as significant at 95% C.I.), followed by Tukey’s post hoc test were used for statistical analysis. Results: Animals receiving OSEE and OSEE + half dose Fluoxetine demonstrated significant antidepressant effect by reduction in the duration of immobility in FST and TST on days 7, 15, 30, but not on day 1. The combination showed antidepressant effect which was comparable to that of full dose of fluoxetine. Conclusion: OSEE alone and its combination with half dose standard drug fluoxetine showed significant antidepressant activity with the combination demonstrating activity comparable to that of full dose standard drug on sub-acute administration.
Effects of postoperative diclofenac on anastomotic healing in rabbit small intestine.

In this experimental study, we investigated the effects of a 5-day postoperative treatment with the nonsteroidal anti-inﬂammatory drug (NSAID) diclofenac on anastomotic healing in rabbits. NSAIDs are widely used analgesics in today’s ‘‘ fast-track surgery, ’’ raising concerns about their potential negative effects on healing in humans. A total of 33 New Zealand White female rabbits underwent laparotomy and 2 separate end-to-end anastomoses of the ileum. The animals were randomized to receive subcutaneous diclofenac 4 mg/kg/d (17 experimental rabbits) or subcutaneous isotonic saline 0.1 mL/kg/ d (16 control rabbits) postoperatively. On the ﬁfth postoperative day, the animals were humanely killed, and anastomotic leakage, anastomotic breaking strength, and histopathologic changes were evaluated. Breaking strength in the diclofenac group was 21% lower than in the placebo group ( P ¼ 0.027). Anastomotic leakage was found in 4 rabbits in the diclofenac group (26.7%). The rabbits treated with diclofenac demonstrated a 16% lower collagen deposition compared with the placebo group ( P ¼ 0.008). In our study, postoperative treatment with diclofenac had a negative effect on the anastomotic healing and strength in the ileum of rabbits. Caution should be taken in the use of diclofenac after gastrointestinal surgery. con-ﬂicting results regarding the correlation between anastomotic breaking strength and peri-anastomotic collagen concentration. Effects of cyclooxygenase inhibition on anastomotic healing following large bowel resection in a rabbit model—a random-EFFECT
Wave Propagation in Infinite Domains: With Applications to Structure Interaction

Wave propagation in infinite or unbounded domains is often encountered in scientific and engineering applications. Theoretical fundamentals and applications of a new numerical model which has the ability to simulate such wave propagation are presented. Attention is focused on linear waves in ideal fluids and elastic domains. Wave propagation based on scalar and vector wave equations, as well as fluid-structure interaction and soil-structure interaction is numerical simulated. The model is based on a coupled finite element/scaled boundary finite element method (FEM/SBFEM). While the FEM maps the near-field, under the immense variety of non-reflecting boundary conditions the SBFEM, developed by Wolf and Song, was chosen. It has some unique features: reduction of the spatial dimension by one without requiring a fundamental solution, no discretisation of free and fixed boundaries and interfaces between different materials, and influence of the infinite far-field could be stored in the form of matrices for further simulations (e.g., different load cases). Benchmark examples show the efficiency and accuracy of the proposed algorithm. Finally, covered fields of applications are: acoustics, dynamic behaviour of offshore wind turbines, and seismic analysis of buildings including soil-structure interaction.
4 Activation of tumor-promoting type 2 macrophages by the EGFR-targeting antibody cetuximab

In a recent randomized phase III clinical trial in metastatic colorectal cancer patients, the addition of the anti-epidermal growth factor receptor (EGFR) monoclonal antibody (MAb) cetuximab to bevacizumab and chemotherapy resulted in decreased efficacy. In order to explain this unexpected clinical observation, we undertook the current hypothesis driven study. Antibody-dependent cell-mediated cytotoxicity (ADCC) by natural killer (NK) cells is generally proposed as one of the anti-tumor mechanisms of MAbs. However, we found that CD163-positive, type 2 macrophages (M2s) are much more abundant in colorectal carcinomas. In vitro analysis of M2 macrophages revealed high levels of Fc-gamma receptors (FcγRs) and PD-L1, and production of IL-10 and VEGF, but not IL-12. These anti-inflammatory and tumor-promoting mediators were released upon co-culture with EGFR-positive tumor cells that were pulsed with low concentrations of cetuximab. Macrophage activation depended on EGFR expression on the tumor cells, FcγRs, target specificity of the MAb and mobility of antibody complexes. Cetuximab-mediated macrophage responses seemed more pronounced for FCGR3A 158-valine carriers, which is the high affinity variant. These results suggest that tumor-promoting type 2 macrophages are activated by this therapeutic MAb in the local tumor microenvironment and argue that this immune mechanism should be taken into account for the application of therapeutic antibodies.
An Interoperability Service for Autonomic Systems

- Interoperability support is a key outstanding requirement for autonomic computing systems, and this need stems from the very success of these systems. Autonomic computing is increasingly popular; soon autonomic control components will be commonplace and present in almost every large or complex application. Interoperability between autonomic managers is an increasingly urgent concern, as the proliferation of autonomic systems inevitably leads to situations where multiple autonomic components coexist and interact either directly or indirectly within the same application or system. Problems can arise when numerous independently designed autonomic components interact, potentially destabilising systems. We advocate a service-based approach to interoperability and present a set of requirements for such an approach as well as a suitable architecture. A key component of this architecture is the Interoperability Service with which Autonomic Managers register their management interests and capabilities, using a management description language. The Interoperability Service automatically discovers and manages potential conflicts between manager components. Developers integrate Autonomic Managers with the Interoperability Service by importing its interfaces. This allows the Interoperability Service to automatically suspend and resume managers, or specific management functions as necessary, driven by the automated conflict detection. We illustrate the use of the Interoperability Service in a data-centre scenario in which independently developed power management and performance management autonomic components operate.
A study on swine management practices in Telangana state

A study was carried out to ﬁnd out socio-economic profile of piggery farmers and various swine management practices adopted by them covering 48 respondents from 12 urban areas and 96 respondents from 24 rural areas from six districts of Telangana state. In urban and rural sectors, maximum respondents (62.50% and 53.13%) were middle aged, illiterate (62.50% and 54.17%), landless farmers (93.75% and 71.88%) with a family size of less than 5 members (87.50% and 89.58%) and majority (80.56%) belonged to Scheduled Tribes. Semi-intensive system (39.58%) of rearing method was the most adopted one followed by extensive (37.50%) and intensive (22.92%) systems in urban sector, while in rural, extensive (52.08%), semi-intensive (38.54%) and intensive (9.38%) were recorded. Supplementation of ration in the form of swill along with scavenging was the widely practiced feeding system in urban (62.50%) and rural (54.17%) areas. Swill feed was procured directly (97.22%) consisting mixture of hostel and hotel waste (91.04%), fed twice a day without measuring (94.03%) and without any processing. Majority of farmers (53.47%) reared Non-descript swine, whereas 39.58% reared Crossbreds and 6.94% reared Yorkshire breeds in both urban and rural areas and natural service was the only practice adopted. Almost all the respondents castrated their boars except the one meant for breeding. Deworming of pigs was irregular by 37.50% and never by 35.42% respondents, whereas in rural areas, 54.17% never practice deworming in pigs. Vaccination was not a practice in pigs by 100% respondents in rural sector, while only 8.33% respondents of urban sector practicing vaccination against foot and mouth disease in pigs. Most of the farmers (89.58%) will not supplement iron to the piglets and do not cut needle teeth. Majority of the farmers (80.56%) have reported a market weight of < 50 kg recorded by 5-7 months of age. The present study revealed that, the piggery sector in Telangana state has not come up well, despite of advantages, benefits and huge demand for pork in the country, hence suitable policies and capacity building of stake holders are to be framed and conducted to educate and create awareness for doubling the farmers income.
1 Cues to the sex ratio of the local population influence women’s preferences for 2 facial symmetry

27 In non-human species, increasing the proportion of potential mates in the 28 local population often increases preferences for high quality mates, while increasing the proportion of potential competitors for mates intensifies within-sex competition. In 30 two experiments, we tested for analogous effects in humans by manipulating pictorial 31 cues to the sex ratio of the local population and assessing women’s preferences for 32 facial symmetry, a putative cue of mate quality in humans. In both experiments, 33 viewing slideshows with varied sex ratios tended to increase preferences for 34 symmetry in the sex that was depicted as being in the majority and tended to 35 decrease preferences for symmetry in the sex that was depicted as being in the 36 minority. In other words, increasing the apparent proportion of a given sex in the 37 local population increased the salience of facial cues of quality in that sex, which 38 may support adaptive appraisals of both potential mates’ and competitors’ quality. This effect of sex ratio was independent of (i.e. did not interact with) an effect of cues to the degree of variation in the attractiveness of individuals in the local population, whereby the degree of variation in men’s, but not women’s, attractiveness modulated symmetry preferences. These findings demonstrate that symmetry preferences in are influenced by cues to the sex ratio of the local population in ways that complement both the facultative responses that have been observed in many other species and theories of both inter-sexual and intra-sexual selection.
Description of the vessel traf ﬁ c within the north Pelagos Sanctuary: Inputs for Marine Spatial Planning and management implications within an existing international Marine Protected Area

kn). Ha- zardous cargo transits accounted for 435,116 km. Vessels within the sanctuary navigated under the ﬂ ags of 90 different states, in variable proportion depending on vessel type (X 2 ¼ 1231, d.f. ¼ 10, p - value o 0.0001). The data presented in this study on high density shipping corridors and hazardous cargo supplies information for the identi ﬁ cation of areas at higher risk from shipping. This data once integrated with available ecological data, can be used to inform ecosystem based management within a Marine Spatial Planning framework. & 2016 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Discovery and Involvement for an Efficient Universal Learning Object Interface

— This paper presents a work in progress whose objective is to develop design criteria for the interface of a Universal Learning Object , based on an open, free web service. The main purpose of this website is to display different technologies and techniques for discovery learning about architecture and heritage sites. It is central to consider usability and accessibility factors so that this website can target a wide diversity of users. Previously, criteria about the learning method were established. The contents to provide a hands-on pedagogical framework were also defined using 3D production and representation tools. This short paper presents the part of the project pertaining to the definition of a graphic interface for this website, which has to combine contents based on the use of tools and technologies, such as 3D printing or Laser cutting. The main result of the project will be an efficient set of learning tools for learning by making, reaching success through involvement.
Predictors of Behavioural Intentions of Teachers to Adopt and Use Information and Communication Technologies in Secondary Schools in Zimbabwe

The use of information and communication technologies (ICTs) also known as educational technology in the teaching and learning context, has become a new normal in all sectors of education world-wide. The most important driver of the use of ICT in education has been the rapid advances in technology and to some extent, natural disasters such as COVID-19 that has affected access to education across all sectors of the education system. As a result, it has become very important that teachers in secondary schools adopt ICT for their teaching. This study therefore seeks to establish factors influencing the behavioural intentions of secondary school teachers to adopt ICT in Zimbabwe. A sample of 251 teachers were selected using stratified random sampling strategy from 10 secondary schools to participate in the study. A structured questionnaire adapted from the Oscarson Scale for Measuring Adoption-proneness (OSMA) was used for data collection. Results of the study showed that the use of technology in teaching, professional development, attitudes toward ICT, gender and ICT support services have a significant influence on the behavioural intentions of secondary school teachers to adopt ICT. A number of challenges that affected the adoption of ICT in secondary schools were also identified. The study has implications on both policy and practice with regard to the adoption of ICT in secondary schools.
Sperm aneuploidy in faroese men with lifetime exposure to dichlorodiphenyldichloroethylenchandigarhe(P,p´-DDE) and polychlorinated biphenyl (PCB) pollutants

Denmark, who provided instrumental support and guidance with the semen quality analysis. This study was supported by the National Institute of Environmental Health Sciences, National Institutes of Health (ES009718, ES017457, ES000002, ES014460); the European Commission through its Sixth Framework Programme for Research and Technological Development [contract no. FOOD-CT-2006–016253, Impact of long-term, low-level mixed element exposure (PHIME)]; and the Faroese Research Council. The authors of this paper declare they have no actual or potential competing financial interest and that their freedom to design, conduct, interpret, and publish research was not compromised by any controlling sponsor as a condition of review or publication. B ackground : Although it is known that sperm aneuploidy contributes to early pregnancy losses and congenital abnormalities, the causes are unknown and environmental contaminants are suspected. o Bjectives : Our goal was to evaluate associations between lifetime exposure to organochlorines, specifically dichlorodiphenyldicholorethylene ( p,p ´-DDE) and polychlorinated biphenyls (PCBs), and sperm aneuploidy in men from for chromosomes X, used to determine rates of XX18, YY18, and total used to estimate relationship between organochlorine exposure and disomy outcomes. and PCB concentrations were both associated with signifi- cantly increased rates of XX18, XY18, and total disomy. Age-14 p,p ´-DDE and PCB concentrations were both associated with significantly increased rates of XX, XY, and total disomy in adulthood. Associations between cord blood concentrations of p,p ´-DDE and PCBs and sperm disomy in adulthood were not consistently significant.
A role for PKC- (cid:2) in Fc (cid:3) R-mediated phagocytosis by RAW 264.7 cells

rotein kinase C (PKC) plays a prominent role in immune signaling, and the paradigms for isoform selective signaling are beginning to be elucidated. Real-time microscopy was combined with molecular and biochemical approaches to demonstrate a role for PKC- (cid:2) in Fc (cid:3) receptor (Fc (cid:3) R)–dependent phagocytosis. RAW 264.7 macrophages were transfected with GFP-conjugated PKC isoforms, and GFP movement was followed during phagocytosis of ﬂuorescent IgG–opsonized beads. PKC- (cid:2) , but not PKC- (cid:4) , concentrated around the beads. PKC- (cid:2) accumulation was transient; apparent as a “ﬂash” on target ingestion. Similarly, endogenous PKC- (cid:2) was speciﬁcally recruited to the nascent phagosomes in a time-dependent manner. Overexpression of PKC- (cid:2) , but not PKC- (cid:5) , PKC- (cid:4) , or PKC- (cid:3) enhanced bead uptake 1.8-fold. Additionally, the rate of phagocytosis in GFP PKC- (cid:2) expressors was twice that of cells expressing GFP PKC- (cid:4) . Expression of the regulatory domain ( (cid:2) RD) and the ﬁrst variable region ( (cid:2) V1) of PKC- (cid:2) inhibited uptake, whereas the corresponding PKC- (cid:4) region had no effect. Actin polymerization was enhanced on expression of GFP PKC- (cid:2) and (cid:2) RD, but decreased in cells expressing (cid:2) V1, suggesting that the (cid:2) RD and (cid:2) V1 inhibition of phagocytosis is not due to effects on actin polymerization. These results demonstrate a role for PKC- (cid:2) in Fc (cid:3) R-mediated phagocytosis that is independent of its effects on actin assembly. IgG-opsonized erythrocytes; (cid:2) RD, regulatory domain of PKC- (cid:2) ; (cid:4) V1, first region fragment of PKC- (cid:4) ; (cid:2) V1, first variable region of PKC- (cid:2) .
Colitis and Colitis-Associated Cancer Are Exacerbated in Mice Deﬁcient for Tumor Protein 53-Induced Nuclear Protein 1 (cid:1)

Tumor protein 53-induced nuclear protein 1 (TP53INP1) is an antiproliferative and proapoptotic protein involved in cell stress response. To address its physiological roles in colorectal cancer and colitis, we generated and tested the susceptibility of Trp53inp1 -deﬁcient mice to the development of colorectal tumors induced by injection of the carcinogen azoxymethane followed by dextran sulfate sodium (DSS)-induced chronic colitis. Trp53inp1 -deﬁcient mice showed an increased incidence and multiplicity of tumors compared to those of wild-type (WT) mice. Furthermore, acute colitis induced by DSS treatment was more severe in Trp53inp1 deﬁcient mice than in WT mice. Treatment with the antioxidant N -acetylcysteine prevented colitis and colitis-associated tumorigenesis more efﬁciently in WT mice than in Trp53inp1 -deﬁcient mice, suggesting a higher oxidative load in the latter. Consistently, we demonstrated by electron spin resonance and spin trapping that colons derived from deﬁcient mice produced more free radicals than those of the WT during colitis and that the basal blood level of the antioxidant ascorbate was decreased in Trp53inp1 -deﬁcient mice. Collectively, these results indicate that the oxidative load is higher in Trp53inp1 -deﬁcient mice than in WT mice, generating a more-severe DSS-induced colitis, which favors development of colorectal tumors in Trp53inp1 -deﬁcient mice. Therefore, TP53INP1 potential for the prevention of colorectal cancer in patients with inﬂammatory bowel disease.