Miracle-dz/UniFAR-FTUs huggingface dataset:
RNA Sequencing of Primary Cutaneous and Breast-Implant Associated Anaplastic Large Cell Lymphomas Reveals Infrequent Fusion Transcripts and Upregulation of PI3K/AKT Signaling via Neurotrophin Pathway Genes

Simple Summary Cutaneous and breast implant-associated anaplastic large-cell lymphomas are usually localized neoplasms with an indolent clinical course compared to systemic ALCL. However comparative analyses of the molecular features of these two entities have not yet been reported. We performed targeted RNA sequencing, which revealed that fusion transcripts, although infrequent, might represent additional pathogenetic events in both diseases. We also found that these entities display upregulation of the PI3K/Akt pathway and show enrichment in genes of the neurotrophin signaling pathway. These findings advance our knowledge regarding the pathobiology of cALCL and BI-ALCL and point to additional therapeutic targets. Abstract Cutaneous and breast implant-associated anaplastic large-cell lymphomas (cALCLs and BI-ALCLs) are two localized forms of peripheral T-cell lymphomas (PTCLs) that are recognized as distinct entities within the family of ALCL. JAK-STAT signaling is a common feature of all ALCL subtypes, whereas DUSP22/IRF4, TP63 and TYK gene rearrangements have been reported in a proportion of ALK-negative sALCLs and cALCLs. Both cALCLs and BI-ALCLs differ in their gene expression profiles compared to PTCLs; however, a direct comparison of the genomic alterations and transcriptomes of these two entities is lacking. By performing RNA sequencing of 1385 genes (TruSight RNA Pan-Cancer, Illumina) in 12 cALCLs, 10 BI-ALCLs and two anaplastic lymphoma kinase (ALK)-positive sALCLs, we identified the previously reported TYK2-NPM1 fusion in 1 cALCL (1/12, 8%), and four new intrachromosomal gene fusions in 2 BI-ALCLs (2/10, 20%) involving genes on chromosome 1 (EPS15-GNG12 and ARNT-GOLPH3L) and on chromosome 17 (MYO18A-GIT1 and NF1-GOSR1). One of the two BI-ALCL samples showed a complex karyotype, raising the possibility that genomic instability may be responsible for intra-chromosomal fusions in BI-ALCL. Moreover, transcriptional analysis revealed similar upregulation of the PI3K/Akt pathway, associated with enrichment in the expression of neurotrophin signaling genes, which was more conspicuous in BI-ALCL, as well as differences, i.e., over-expression of genes involved in the RNA polymerase II transcription program in BI-ALCL and of the RNA splicing/processing program in cALCL.
Risk assessment and decision-making for residential housing adapting to increasing storm-tide inundation due to sea-level rise in South East Queensland, Australia

The exposures and risks of coastal built as well as natural assets to storm-tide inundation are expected to be more pronounced as a result of the reduced recurrence interval or the increased occurrence frequency of storm tides in Australia due to sea-level rise. This study investigates the distributions of direct damage losses and adaptation benefits for residential buildings considering uncertainties of storm tides under projected sea-level rises in South East Queensland, one of the fastest-growing regions in Australia in the last two decades. The study subsequently indicates that ‘deterministic decision-making’ based on an individual hazard or scenario could be fundamentally flawed for coastal planning and adaptation as a result of uncertain natures in coastal hazards under changing climate. The developed knowledge can eventually facilitate better decision-making processes for adapting coastal residential buildings to future climate change under considerable uncertainties. It is also found that constructing new buildings with higher floor heights is a relatively inexpensive but also a highly effective approach insensitive to uncertainties for reducing future damage losses of storm-tide inundation.
Antioxidant Potentials of Pentaclethra macrophylla Seed (Ugba) on Mercury Toxicity Induced Hepatic, Renal and Testicular Oxidative Stress in Male Albino Rats

Aim: This study aimed to evaluate the antioxidant potentials of Pentaclethra macrophylla seed (Ugba) on mercury-induced hepatic, renal and testicular oxidative stress in male Albino Rats. Study Design: This study is an experimental study. Place and Duration of Study: Department of Animal and Environmental Biology Animal House, Rivers State University, Port Harcourt, Nigeria, between January 2019 and January 2021. Methodology: Thirty-six (36) adult male albino rats weighing approximately 135±1.5g were purchased from the University of Port Harcourt, Rivers State, Nigeria. They were housed in plastic suspended cages, placed in well-ventilated conditions and provided with rat diet and water, and acclimatized for two weeks. Fresh matured seeds of Pentaclethra macrophylla (African oil bean seed) were sourced locally from markets in Imo state, Nigeria. The maceration technique was used to carry out an ethanolic extract of the plant seed. Mercury chloride salt was purchased from Port Harcourt. A standard dose of 3.0mg/kg body weight of mercury chloride obtained from acute toxicity study dose determination was administered to the rats for 30 days after they were divided into six groups of six rats per group. After 30 days, all the animals were weighed, anesthetized using chloroform. Tissue samples of liver, kidney, and testis were collected and homogenized in phosphate-buffered saline and stored at 40C for determination of oxidative stress assessment. Malondialdehyde, Reduced Glutathione (GSH), Catalase Activity, superoxide dismutase (SOD) activity, Glutathione Peroxidase Activity were analyzed using the homogenized sample. Data were expressed as mean ±SD, and the statistical analysis was performed with the SPSS statistics 23.0, and p values less than . 05 were considered statistically significant. Results: The results showed that there were significant increases (P<.05) in the liver, kidney, and testicular MDA and significant decreases (p<.05) in SOD, CAT, GSH, and GPx activities in group 2 rats versus control. However, after treatment with different concentrations of Pentaclethra macrophylla, MDA activity significantly decreased (P<.05), while SOD, CAT, GPx, and GSH significantly increased (P<.05). Conclusion: The results obtained from the study showed that mercury chloride has the potential to cause liver, kidney, and testicular toxicity to adult male albino rats, and this toxicity was exerted majorly through oxidative stress and lipid peroxidation. However, treatment with Pentaclethra macrophylla seed extract ameliorated oxidative stress.
Effect of donkey milk addition on the acceptability of Caprino, a typical goat cheese from Basilicata region, Italy

In this preliminary study we evaluated the effect of different donkeys ’ milk additions in cheese making on the acceptability of fresh Caprino, a typical goat cheese produced in a region of southern Italy. In cheese making three batches were considered: A1 only goats ’ milk, A2 and A3 with the addition of 5% and 10% of donkeys ’ milk, respectively. With the exception of colour, the lowest don-keys ’ milk addition improved the acceptability of Caprino cheese. In particular, signi ﬁ cant highest ratings ( P < 0.05) were observed on odour, ﬂ avour, texture and on overall liking.
A Dual-domain Super-resolution Image Fusion Method with SIRV and GALCA Model for PolSAR and Panchromatic Images

Hyperspectral/multispectral and panchromatic of optical remote sensing images are commonly used for multi-sensor image fusion, which has been applied in various applications of Earth observation. However, the utilization of optical remote sensing data suffers from the limitation of bad weather and cloud contamination. To address aforementioned issue and enhance spatial details of polarimetric synthetic aperture radar (PolSAR) image, a novel dual-domain super-resolution image fusion method is proposed by combining improved spherically invariant random vector (ISIRV) model with generalized adaptive linear combination approximation (GALCA) technology in this study. The proposed method decomposes the task of image fusion into polarimetric and texture domain fusion by integrating polarimetric components of PolSAR image and texture detail component of panchromatic image, which can significantly improve spatial resolutions of PolSAR image while preserving polarimetric information. The data fusion experiment is implemented with three data sets including panchromatic images of Gaofen-1(GF-1)and Gaofen-2(GF-2)and the quad-pol SAR data of Gaofen-3(GF-3)and Radarsat-2. Results show that the proposed dual-domain image fusion method provide a better performance compared with state-of-the-art multi-sensor fusion methods (BT, PCA, GS, Indusion and PRACS) regarding qualitative and quantitative evaluations. Additionally, results of image fusion are applied to image classification over agricultural and urban areas of China, which shows that classification accuracy is significantly improved when compared with the result using only the original image.
Aerodynamics of Cooling Jets Introduced in the Secondary Flow of a Low-Speed Turbine Cascade

The aerodynamic behaviour of cold discrete jets in a cold direction secondary flow is investigated. Configurations including single jets and rows of jets are studied. These jets are introduced through the side wall of a low speed nozzle turbine cascade. The experimental set up and absolute flow respect the axial the jet behaviour are fully described. The effects of location with respect to the blades, mass flow ratio, yaw and incidence angles on the aerodynamics of single jets are investigated. The influence of neighbouring jets is detailed in the case of multiple jet configurations. The interaction with the secondary flow is presented. The local pressure and velocity fields, trajectories and visualizations Subscript are discussed. The measuring apparatus includes a five hole probe and an hot wire for intermittency measurements, This suggests that the jet flow may counterbalance the classical secondary flow effect.
A Case Study of Learners’ Engagement in Mobile Learning Applications

Although mobile learning applications play a crucial role in today’s education and can support learning, the low retention rate is a prevalent challenge in mobile learning. Existing studies have found that interpersonal interaction, high expectations, and supportive environment (from an educational perspective) as well as compatibility, interactivity, and usability (from a marketing perspective) can impact learners’ engagement in learning activities and customers’ engagement in mobile applications. However, comprehensive studies investigating learners’ engagement in mobile learning applications from educational and marketing perspectives are rare. To fill the research gap, we analyzed learners’ reviews on five top-ranked lifelong learning applications (Udemy, LinkedIn Learning, Coursera, edX, and Skillshare). Inductive coding was used to identify critical factors impacting learners’ engagement in mobile learning applications, such as usability, availability of learning experiences, features to facilitate learning, interpersonal interaction, and incentives for completion. We further explored specific engagement strategies displayed in the analyzed applications through an analytical evaluation. Besides, this study expands Hew’s model of learners’ engagement and suggests new conceptual relationships between critical factors impacting learners’ engagement, self-determination theory, and learners’ engagement.
Quality Certification Scheme in the Construction Industry of China

Compared with other industries, the construction industry is characterized by activities, which are discontinuous, dispersed, diverse and distinct. Quality management in the construction setting is, thus, more difficult. This paper aims to study the status of implementation of a quality certification scheme: ISO 9000: 1994 in the construction industry of China and to unveil the motivation factors for contractors to implement the scheme in a planned economy environment. The study will evaluate contractors' experience in developing a quality assurance (QA) system, and collect contractors' views on its benefits, which may be different from findings of research in a market economy setting. An additional finding of the study indicates that most contractors of China in the study describe that the most effective quality management system is ‘ISO 9000 integrated with Total Quality Management (TQM)’.
Antecedents of Student Satisfaction: The Role of Student Perceived Service Quality

There is a lack of attention from past studies on the role of antecedents in the private higher education in Malaysia. Thus, this paper aim to examine the roles of reliable information and past experience on student’s perceived service quality and satisfaction among the undergraduate students of private universities in Malaysia. A self-administered questionnaire was adopted and collected 388 valid data from the 9 private universities in Malaysia. The SERVPERF instrument was adopted to evaluate the perceived service quality among the undergraduate students. The PLS-SEM was applied to analyze the students’ responses in determining the role of antecedents in improving student satisfaction by providing quality tertiary education in the private universities. The findings depicted that reliable information is significantly related with student perceived service quality. However, there is no relationships between past experience and student perceived service quality. Student perceived service quality is found significantly related to student satisfaction. This paper provides a valuable contribution in the body of knowledge of the antecedent and consequence of perceived service quality. The findings of the study help the management of the universities to improve the student satisfaction through the focus on the role of antecedents, particularly reliable information. Several implications are offered which would benefits Malaysia private universities and Ministry of Higher Education.
Oligodendrocyte precursor cell transplantation promotes angiogenesis and remyelination via Wnt/β-catenin pathway in a mouse model of middle cerebral artery occlusion

White matter injury is a critical pathological characteristic during ischemic stroke. Oligodendrocyte precursor cells participate in white matter repairing and remodeling during ischemic brain injury. Since oligodendrocyte precursor cells could promote Wnt-dependent angiogenesis and migrate along vasculature for the myelination during the development in the central nervous system, we explore whether exogenous oligodendrocyte precursor cell transplantation promotes angiogenesis and remyelination after middle cerebral artery occlusion in mice. Here, oligodendrocyte precursor cell transplantation improved motor and cognitive function, and alleviated brain atrophy. Furthermore, oligodendrocyte precursor cell transplantation promoted functional angiogenesis, and increased myelin basic protein expression after ischemic stroke. The further study suggested that white matter repairing after oligodendrocyte precursor cell transplantation depended on angiogenesis induced by Wnt/β-catenin signal pathway. Our results demonstrated a novel pathway that Wnt7a from oligodendrocyte precursor cells acting on endothelial β-catenin promoted angiogenesis and improved neurobehavioral outcomes, which facilitated white matter repair and remodeling during ischemic stroke.
Racial Disparities in Lifer Parole Outcomes: The Hidden Role of Professional Evaluations

One in seven people in prison in the US is serving a life sentence, and most of these people will eventually be eligible for discretionary parole release. Yet parole hearings are notoriously understudied. With only a handful of exceptions, few researchers have considered the ways in which race shapes decision-makers’ perception of parole candidates. We use a data set created from over seven hundred California lifer parole hearing transcripts to examine the factors that predict parole commissioners’ decisions. We find significant racial disparities in outcomes, with Black parole candidates less likely to receive parole grants than white parole candidates, and test two possible indirect mechanisms. First, we find that racial disparity is unassociated with differences in rehabilitative efforts of Black versus white parole candidates, suggesting that differential levels of self-rehabilitation are not responsible for the disparity. Second, we test the hypothesis that racial disparity owes to commissioners’ reliance on other professionals’ determinations: psychological assessments, behavioral judgments, and prosecutors’ recommendations. We find that reliance on these evaluations accounts for a significant portion of the observed racial disparity. These results suggest that inclusion of professional assessments is not race-neutral and may create a veneer of objectivity that masks racial inequality.
Analysis of rapid manufacturing—using layer manufacturing processes for production

Abstract Rapid prototyping (RP) technologies that have emerged over the last 15 years are all based on the principle of creating three-dimensional geometries directly from computer aided design (CAD) by stacking two-dimensional profiles on top of each other. To date most RP parts are used for prototyping or tooling purposes; however, in future the majority may be produced as end-use products. The term ‘rapid manufacturing’ in this context uses RP technologies as processes for the production of end-use products. This paper reports findings from a cost analysis that was performed to compare a traditional manufacturing route (injection moulding) with layer manufacturing processes (stereolithography, fused deposition modelling and laser sintering) in terms of the unit cost for parts made in various quantities. The results show that, for some geometries, it is more economical to use layer manufacturing methods than it is to use traditional approaches for production in the thousands.
Maintenance and Repair Options for Pervious Concrete

While permeable pavements have been applied in limited use in the southeastern United States since the 1970's, only recently have they become a more wide-spread technology for stormwater management. Various industry groups have done well promoting the benefits of permeable pavements, however maintenance issues are rarely discussed in-depth. Maintenance of permeable pavements involves cleaning to restore permeability and the repair of structural and non-structural deficiencies. This paper discusses common causes and identification of common and not so common pavement distresses. Methods to assess surface condition and permeability are presented along with suggestions for cleaning and surface repair. This paper is designed to assist with selection of appropriate remediation techniques for individual levels of pervious concrete distresses.
Turkish partitive constructions and (non-)exhaustivity

Turkish exhibits explicit partitive constructions as hayvan-lar-dan beş fil (animal-pl-abl five elephant ‘five elephants from / of the animals’) with two overt nouns, one for the superset (animal) and one for the subset (elephant). These explicit partitive constructions show optional accusative case marking on the subset denoting noun in direct object position, i.e. Differential Object Marking (DOM). In an earlier paper (von Heusinger, Kornfilt & Kizilkaya 2019), we argue that the results of a grammaticality judgment task described in that paper can be interpreted as showing that accusative case marking of explicit partitives encodes specificity. However, the results are also compatible with an interpretation of the accusative-marked partitives as definite expressions, encoding definiteness, i.e. exhaustivity. In the present paper we present a follow-up acceptability judgment task that shows that these partitives can easily be interpreted as indefinite, i.e. as non-exhaustive expressions. These original results also support the more general assumption of von Heusinger & Kornfilt (2005) that accusative case marking in Turkish encodes specificity rather than definiteness. Europaea 13
Relapsed/Refractory Diffuse Large B-Cell Lymphoma: A Look at the Approved and Emerging Therapies

Approximately 40% of patients with diffuse large B cell lymphoma (DLBCL) do not respond or develop relapsed disease after first-line chemoimmunotherapy. A minority of these patients can be cured with autologous hematopoietic stem cell transplantation (AHCT). Although chimeric antigen receptor (CAR) T cells have transformed the treatment paradigm of relapsed/refractory DLBCL, only 30–40% of patients achieve durable remissions. In addition, many patients with relapsed/refractory DLBCL are ineligible to receive treatment with CAR T cells due to comorbidities or logistical limitations. Since 2019, the following four non-CAR T-cell treatments have been approved in relapsed/refractory DLBCL: polatuzumab in combination with bendamustine and rituximab, selinexor, tafasitamab plus lenalidomide, and loncastuximab. In this article, I review the data behind these four approvals and discuss important considerations on their use in clinical practice. I also review emerging therapies that have shown promising early results in relapsed/refractory DLBCL including the bispecific antibodies, antibody–drug conjugates, Bruton tyrosine kinase inhibitors, BCL2 inhibitors, immune checkpoint inhibitors, and epigenetic modifiers.
Damage Analysis of Hanshin Expressway Viaducts during 1995 Kobe Earthquake. I: Residual Inclination of Reinforced Concrete Piers

The damage suffered by elevated viaducts of the Hanshin Expressway Kobe Route during the 1995 Kobe earthquake is described with emphasis on reinforced concrete (RC) piers. Although many piers were severely damaged, it is also true that the damage to many piers appeared moderate or even mild. On the other hand, a number of piers suffered from large residual inclination in spite of the apparently light damage. By considering that the large residual inclination of piers included severe earthquake-induced damage, it is pointed out that almost all the RC single piers from P35 to P350 received consistently severe damage. The cause of large residual inclination, especially in apparently nondamaged piers, is studied. A dynamic analysis of a single RC pier is conducted to study the relationship between residual inclination and residual deformation of a pier. As a result, we find that the flexural residual deformation of a pier cannot explain the observed large residual inclination, but it is suggested that the pulling out of reinforcing bar from the footing can be a primary cause of the observed large residual inclination.
THE INFLUENCE OF STRUCTURAL FLEXIBILITIES ON THE STRAIGHT-RUNNING STABILITY OF MOTORCYCLES

SUMMARY A new tyre model for studies of motorcycle lateral dynamics, and three new motorcycle models, each incorporating a different form of structural compliance, are developed. The tyre model is based on “taut string” ideas, and includes consideration of tread width and longitudinal tread rubber distortion and tread mass effects, and normal load variation. Parameter values appropriate to a typical motorcycle tyre are employed. The motorcycle models are for small lateral perturbations from straight running at constant speed, and include (a) lateral compliance of the front wheel in the front forks, (b) torsional compliance of the front forks, and (c) torsional compliance in the rear frame at the steering head about an axis perpendicular to the steering axis. Results in the form of eigenvalues, indicating modal damping properties and natural frequencies are presented for each model. The properties of four large production machines for a range of forward speeds, and the practicable range of stiffnesses are .