Miracle-dz/UniFAR-FTUs huggingface dataset:
Practicality Analysis of PBL-Based Mathematics in Circle Material

This study aims to analyze the practicality level of the PBL-based mathematics module on circle material. The practicality analysis of the developed mathematics module aimed to determine the ease of use of the module according to teachers and students. This research is a qualitative descriptive study. A practicality questionnaire was used to collect the data. The subjects in this study were 2 mathematics teachers and 13 grade VIII students at SMPN 2 Jumapolo. The results of the analysis showed that the average of total score of the teacher practicality questionnaire was 78.15 and could be stated as practical. The average score of the student practicality questionnaire was 74.87, could be stated as practical. Based on the results of the analysis of the teacher and student practicality questionnaires, it can be concluded that the mathematics module based on problem-based learning on circle material is considered practical and can be used in mathematics learning.
Incidence of avian malaria in hummingbirds in humid premontane forests of Pichincha Province, Ecuador: A pilot study

Background and Aim: Avian malaria is a tropical disease caused by protozoans of the genera Plasmodium and Haemoproteus. As a nonlethal disease, avian malaria can affect the lifespan and reproductive rate of birds. If there is a differential effect depending on bird species, then this disease might have a significant effect on avian biodiversity. The current study aimed to determine the incidence of Plasmodium in hummingbirds in humid premontane forest areas. Materials and Methods: Blood samples (n=60) were collected from hummingbirds from two areas (Santuario de Aves Milpe and Hacienda Puyucunapi) of Pichincha Province, Ecuador. Prevalence and parasitemia were determined by microscopic examination of blood smears stained with Giemsa reagent. Both study sites are part of a 1000 m elevational gradient; hence, elevation was used as a predictor variable for prevalence and parasitemia levels in a Mann–Whitney U-test. This test was also used to test for a sex bias. Results: This study reports on a total of 12 bird species that inhabit both study sites. At Milpe, the lower elevation site, a prevalence of 100% was recorded, whereas at Puyucunapi, the prevalence was 96%. The combined prevalence was 97%. Elevation and sex did not influence prevalence nor parasitemia in hummingbirds. Conclusion: This study does not suggest a significant elevation or sex bias on prevalence and parasitemia in hummingbirds.
Waist circumference relates to blood pressure among adults

Introduction: Approximately 7 million people die every year worldwide due to the deleterious effects of high blood pressure. Increased body weight is a significant risk factor for cardiovascular diseases and their association has been the subject of many studies. The present study was undertaken to examine the presence of obesity on the basis of BMI and to see how different parameters relate with the blood pressure readings in healthy individuals. The parameters measured included body mass index, waist to hip ratio, percentage of total body fat and waist circumference. The correlation of theses parameters with the high blood pressure was studied. We aimed to find out the parameter that would relate more closely to the high blood pressure readings. Materials and Methods: A cross sectional non-interventional study was conducted after the approval of the ethical committee of the institute. Two hundred subjects of age group 18-20 years were included in the study. Correlation analysis was done using Primer of Biostatistics version 7software. Results: A total of 80 males and 120 females took part in the study. The mean age was 18.18 years for males and 18.7 years for females. SBP showed positive and statistically significant correlation with height (r=0.5), weight (r=0.5), WC (r=0.3), WHR (r=0.22). DBP showed positive and statistically significant correlation with weight (r=0.3), BF% (r=0.26) and BMI (r=0.24). Conclusion: Obesity and high BP are positively correlated. Waist circumference can be better predictor of obesity related risk than waist hip ratio, body mass index and body fat percentage.
Miswak starch-based gel as topical preparation for potential management of infective ulceration

Salvadora persica or Miswak is known for its antibacterial activities towards various bacteria species, including several oral pathogens. Although Miswak has many therapeutic potentials, the delivery medium is vital to ensure that the desired effects can be delivered to the target site. Ideally, starch is a biopolymer that exhibits muco-adhesive property, suitable as topical delivery material. Hence, this study was done to develop starch-based gel for Miswak antibacterial compound delivery system. In this study, Miswak hexane extract was incorporated into starch-based gels and stored at 4⁰C and room temperature. Miswak gel was tested for its antibacterial activity, and its stability was monitored by visual observation. As a result, the mean inhibitory zones of Miswak gels were found to be 22.67 ± 3.79 mm (4°C) and 20.67 ± 2.08 mm (room temperature) at day-1. The inhibitory zone decreased after 30 days with 13.00 ± 2.52 mm (4°C), and 12.00 ± 1.00 mm (room temperature). It was observed that the gels were stable where there were no colour changes, no phase separation and degradation, visualised up to day-60. In conclusion, the starch-based gel is a suitable delivery system for Miswak extract, thus as potential management for infective ulceration.
University of Groningen Noninvasive pulse pressure variation and stroke volume variation to predict fluid responsiveness at multiple thresholds Vos,

Background Pulse pressure variation (PPV) and stroke volume variation (SVV) are dynamic preload variables that can be measured noninvasively to assess fluid responsiveness (FR) in anesthetized patients with mechanical ventilation. Few studies have examined the effectiveness of predicting FR according to the definition of FR, and assessment of inconclusive values of PPV and SVV around the cut-off value (the ‘‘grey zone’’) might improve individual FR prediction. We explored the ability of noninvasive volume clamp derived measurements of PPV and SVV to predict FR using the grey zone approach, and we assessed the influence of multiple thresholds on the predictive ability of the numerical definition of FR. Methods Ninety patients undergoing general surgery were included in this prospective observational study and received a 500 mL fluid bolus as deemed clinically required by the attending anesthesiologist. A minimal relative increase in stroke volume index (:SVI) was used to define FR with different thresholds from 10-25%. The PPV, SVV, and SVI were measured using the Nexfin device that employs noninvasive volume clamp plethysmography. Results The area under the receiver operator characteristic curve gradually increased for PPV / SVV with higher threshold values (from 0.818 / 0.760 at 10% :SVI to 0.928 / 0.944 at 25% :SVI). The grey zone limits of both PPV and SVV changed from 9–16% (PPV) and 5– 13% (SVV) at the 10% :SVI threshold to 18–21% (PPV) and 14–16% (SVV) at the 25% :SVI threshold. Conclusion Noninvasive PPV and SVV measurements allow an acceptable FR prediction, although the reliability of both variables is dependent on the intended increase in SVI, which improves substantially with concomitant smaller grey zones at higher :SVI thresholds. Author contributions Jaap Jan Vos, Michel M.R. F. Struys, Thomas W.L. Scheeren, and Alain F. Kalmar were involved in data interpretation. Marieke Poterman, Pieternel Papineau Salm, and Alain F. Kalmar were involved in data recording. Jaap Jan Vos, Kai van Amsterdam, and Alain F. Kalmar were involved in data analysis. Alain F. Kalmar was involved in patient inclusion and care. All authors were involved in writing the manuscript. This article is accompanied by an editorial. Please see Can J Anesth 2015; 62: this issue. Electronic supplementary material The online version of this article (doi:10.1007/s12630-015-0464-2) contains supplementary material, which is available to authorized users. J. J. Vos, MD, PhD (&) M. Poterman, MD P. P. Salm, MD K. Van Amsterdam, MSc M. M. R. F. Struys, MD, PhD T. W. L. Scheeren, MD, PhD A. F. Kalmar, MD, PhD Department of Anesthesiology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, PO BOX 30 001, 9700 RB Groningen, The Netherlands e-mail: j.j.vos@umcg.nl A. F. Kalmar, MD, PhD Department of Anesthesiology and Intensive Care Medicine, Maria Middelares Hospital, Ghent, Belgium 123 Can J Anesth/J Can Anesth (2015) 62:1153–1160 DOI 10.1007/s12630-015-0464-2
Kinematic evolution of the Pan-African shear zones of South Maradi, southern Niger

The Pan-African Province (PAP) of south Maradi (Niger) corresponds to the northeastern part of the Benin-Nigerian Shield, which is part of the Pan-African Mobile Belt, located to the East of the West African Craton. This study focuses on the microstructural study supported by geochronological data of the South Maradi Pan-African shear zones. The structural analysis of the Pan-African shear bands, combined with the previous radiometric data allowed to highlight a polyphase history of this northeastern part of the Benin-Nigerian Shield. Two major tectonic periods are highlighted: A ductile to brittle Pan-African deformation stage (D1) relayed by a brittle post-Pan-African deformation stage (D2). The first phase D1 consists of two episodes noted D1a and D1b: (1) the D1a episode was a ductile pan-African deformation stage with a strong coaxial component, which favoured the development of symmetric fabrics of foliation. The tectonic regime was characterized, first by a NW-SE (~N140°) trending pure-shear-dominated shortening episode, which prevailed between 617.9 ± 2.8 to 589 ± 1.9 Ma. Then during episode D1a, the shortening direction evolved gradually from NW-SE to ~E-W (N90°-N70°). This change of direction is due to the constraint coming from the Pan-African orogeny. The deformation had progressively a rotational component and this is how D1b episode began. This latter was characterized by a brittle-ductile deformation, associated with the formation of mylonitic gneiss and micaschist. So, the counter clockwise sinistral rotation of the shortening axis Z (from N140° to N90°- N70°) reveals a Pan-African continuum of deformation between D1a and D1b episode. (2). Subsequently, a stage of brittle deformation D2 affected all the previous structures. This D2 stage is marked by a continental-scale system of conjugated strike-slip faults, NE-SW and NW-SE trending. This investigation contribute to knowledge of Pan-African kinematic evolution of Benin-Nigerian Shield, particularly its northeastern part (South Maradi).
University of Birmingham Familiality and SNP heritability of age at onset and episodicity in major depressive disorder

Citation for published version (Harvard): Ferentinos, P, Koukounari, A, Power, R, Rivera, M, Uher, R, Craddock, N, Owen, MJ, Korszun, A, Jones, L, Jones, I, Gill, M, Rice, JP, Ising, M, Maier, W, Mors, O, Rietschel, M, Preisig, M, Binder, EB, Aitchison, KJ, Mendlewicz, J, Souery, D, Hauser, J, Henigsberg, N, Breen, G, Craig, IW, Farmer, AE, Müller-myhsok, B, Mcguffin, P & Lewis, CM 2015, 'Familiality and SNP heritability of age at onset and episodicity in major depressive disorder', Psychological Medicine, vol. 45, no. 10, pp. 2215-2225. https://doi.org/10.1017/S0033291715000215
A Review of the Role of Cross-Language Similarity in L2 (Morpho)Syntactic Processing as Revealed by fMRI and ERP Methods

This review examines whether similarity between the fi rst language (L1) and second language (L2) infl uences the (morpho)syntactic processing of the L2, using both neural location and temporal processing information. Results from functional magnetic resonance imaging (fMRI) and event-related potential (ERP) studies show that nonnative speakers can exhibit nativelike online L2 (morpho)syntactic processing behavior and neural patterns. These fi ndings are contrary to predictions of the shallow structure hypothesis for syntactic processing (Clahsen & Felser, 2006a, 2006b). The data are in line with predictions of the (morpho)syntactic domain of the unifi ed competition model of L2 acquisition (MacWhinney, 2005): Differences in L2 processing as compared to the L1 (or to native speakers of the L2) were generally associated with constructions that were crosslinguistically dissimilar or unique to the L2. The processing of crosslinguistically similar constructions generally produced no differences in brain activity between the L1 and L2. Overall, the available data suggest that cross-language similarity is an important factor that infl uences L2 (morpho)syntactic processing.
The Effect of Using E-Learning Based Guided Discovery Learning Model Based on Self-Efficacy Towards Student Learning Outcomes In Biology Class in Reproductive System Subject in High School

Guided Discovery Learning is a learning model that is considered capable of improving student learning outcomes while Self-efficacy is self-confidence in an individual’s abilities. This study aims to determine the effect of guided discovery learning model and self-efficacy towards student learning outcomes in biology class. The method used in this research is quasi-experimental. This study has a sample of 200 students from 256 students. The technique used is Cluster random sampling. The instruments used are multiple choices and questionnaire. Data from the three variables are analysed using the Two-Way ANOVA Test and the Tukey Test, at a significance level of 0.005. Based on data analysis, it can be concluded that Guided Discovery Learning model and an individual’s self-efficacy can improve student learning outcomes. Both Guided Discovery Learning model and self-efficacy can improve student learning outcomes and have positive interactions between the two variables. The implications of this study are as a basis for increasing the use of learning models using technology, and teachers as educators are able to encourage students to improve self-efficacy.
Taste-aroma Interactions in Lemon-flavored Model Beverages: Influence of Sweeteners on Aroma Perception and In Vivo Aroma Release

The aim of this study was to investigate the relationship between the influence of sweeteners on the in vivo aroma release from beverages and aroma perceptions. Equi-sweet and lemon-flavored model beverages were prepared using sucrose, acesulfame potassium (ACK), aspartame (ASP) and sucralose. The amounts of in-mouth odorants exhaled through the nostrils during the consumption of the model beverages were compared using the Retronasal Flavor Impression Screening System (R-FISS) by 4 trained panelists, and the relationship between the in vivo aroma release and their aroma perceptions was evaluated. As a result of the sensory evaluation using quantitative descriptive analysis, the lemon-like aroma of the beverage containing ACK was perceived to be significantly weaker, while the green aroma of the beverage containing sucralose and the spicy aroma of the beverages containing ASP and sucralose were perceived as significantly stronger than the other beverages. In contrast, there were no in-mouth odorants showing significant differences in their amounts that were common to the 4 panelists. Therefore, it was found that the sweeteners could have a small impact on the in vivo aroma release from the model beverages. These results suggested that differences in aroma quality of the model beverages by the types of sweeteners could result from factors other than the in vivo aroma release. Furthermore, it is highly likely that the taste-aroma interactions caused by the aroma and taste compounds would be one of the factors having a significant impact on the different aroma perceptions of the beverages containing the different sweeteners.
An Analysis of the Red Giant Bump

The red giant branch bump is a phenomenon that consists of a decrease in luminosity for a given time during the red giant branch phase and has been known for some time. Nevertheless, discrepancies between models and observations show that it is not yet fully understood. It is therefore interesting to try to understand the influence of various parameters that are part of the structure of the star on the bump. We have used the stellar evolution code called Clés to study the influence of the total mass of the star, its overshooting parameter, its undershooting parameter, its metallicity, and the microscopic and turbulent diffusion. To study the effects of changing these parameters, the attention was given to the track of the star in the Hertzsprung-Russell diagram during its evolution and on the hydrogen abundance profile of the star, the discontinuity in the latter being the key element for the appearance of the bump. Effects can be seen on the bump for each of the parameters studied, which can be summarized in two categories: a change in the luminosity at which the bump occurs and a change in the size of the bump, thus the importance of the observed decrease in luminosity.
A STUDY ON L2 RHYTHM ACQUISITION BY DUTCH LEARNERS OF SPANISH AND SPANISH LEARNERS OF DUTCH

This study examines the acquisition process of speech rhythm in Dutch learners of Spanish (DLS) and Spanish learners of Dutch (SLD) at different proficiency levels to determine whether learning direction This research was made possible through grants from the Prins Bernhard Cultuurfonds (40005750/HEV/ILE), the Jo Kolk fund, the Grup de Recerca Consolidat 2017 (SGR _ 971) and Spanish Ministry of Economy and Competitiveness (FFI2015-6653). We thank Gerdientje Oggel, Johanna Sattler, Arthur Verbiest, and Astrid van Winden for their help during data collection. We gratefully acknowledge Joan Borràs-Comes, Elena Kireva, Mart Lubbers, and Paolo Mairano for their help with data analyses, and Núria Esteve-Gibert and Constantijn Kaland for coding part of the data to test coding reliability. Finally, thanks are due to three anonymous reviewers for their helpful input and feedback on the content of this manuscript. Any errors that remain are our own. Preliminary versions of the first two studies of this paper were presented at the Speech Prosody conference in May 2016 in Boston and at the New Sounds conference in June 2016 in Aarhus, Denmark, respectively. The current paper includes a more detailed theoretical background and description of the experimental methods, more extensive discussions of the results, and more advanced statistical analyses over the complete dataset. *Correspondence concerning this article should be addressed to Lieke van Maastricht, Radboud University, Postbus 9102, 6500 HC Nijmegen, Netherlands. E-mail: l.vanmaastricht@let.ru. nl Copyright © Cambridge University Press 2018. This is an Open Access article, distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives licence (http://creativecommons.org/ licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is unaltered and is properly cited. The written permission of Cambridge University Press must be obtained for commercial re-use or in order to create a derivative work. affects the success of rhythm acquisition in a foreign language (L2). Analyses of lengthening effects showed that the two learner groups followed different developmental paths in their acquisition of accentual and final lengthening: Both groups showed transfer effects from the L1, but while the DLS systematically approached their target until attainment, the SLD showed more variability in their development. In addition, syllable structure complexity affected L2 rhythm acquisition, and to a substantially larger extent for the SLD compared to the DLS. The results support a model of L2 rhythm acquisition in which learning direction is included as a factor, and that allows for the interaction of various language-specific properties that contribute to speech rhythm, like syllable structure complexity.
Optimizing Chemotherapy of Pancreatic Acinar Cell Carcinoma: Our Experiences and Pooled Analysis of Literature

Background: Pancreatic acinar cell carcinoma (PACC) is rare, and its appropriate treatment remains unknown. We aim to explore the characteristics and optimal treatment of it. Methods: The data on clinicopathologic characteristics, molecular alteration, treatment, and survival of patients diagnosed with PACC at the Sun Yat-sen University Cancer Center from 2005 to 2020 were collected. The optimal treatment was explored by co-analyzing our results and published literatures. Results: Twenty-two PACC patients were enrolled. Eight of 17 non-metastatic patients received adjuvant chemotherapy. The patients receiving fluoropyrimidine-based regimen (n = 3) had a better median disease-free survival (mDFS) than those with gemcitabine-based regimen (n = 5) (unreached vs 27 months). Eight metastatic patients received first-line chemotherapy. Four patients received second-line chemotherapy. The objective response rate (ORR) of the fluoropyrimidine-based regimen was 85.7% (6/7), much better than that of the gemcitabine-based regimen (0/5). One patient who had responded to the first-line FOLFIRINOX (5-fluorouracil + oxaliplatin + leucovorin + irinotecan) regimen received olaparib as maintenance treatment for 5 months with good tolerance. Thirty-one published literatures, with a total of 86 cases, were included in the co-analysis. The ORR of the first-line fluoropyrimidine-based regimen (n = 47) was higher than that of gemcitabine-based regimen (n = 39) (59.6% vs 15.3%, P < .001). Eight of 11 patients treated with the FOLFIRINOX regimen achieved partial response (PR). Conclusions: For patients with metastasis, a fluorouracil-based regimen such as FOLFIRINOX may be preferred, and maintenance treatment of poly ADP-ribose polymerase (﻿PARP) inhibitors after effective platinum-containing treatment for breast cancer susceptibility gene (BRCA) mutation patients must be assessed.
Elevated Temperature Effects on the Behavior of One-Way Fi-brous Reinforced Concrete Slabs

In this research, the effect of elevated temperature on the flexural behavior of one-way reinforced concrete slabs under service static loads contain different volume fraction (0.25% , 0.75% and 1.25%) of steel fibers and different addition ratios (15%, 20% and 25%) of fly ash in addition to the reference slabs with not any additives was studied. For this purpose, thirty cylinders (150 *300)mm , thirty prisms (100 * 100 * 500)mm and forty one-way slabs (900 * 350 * 70) mm were cast and tested. The one-way tested slabs were divided into two groups. The first group (of twenty slabs) were tested to determine the ultimate flexural strength under static loads at normal temperature. While the second group (of twenty slabs) were tested to determine the flexural behavior of slabs under static service loads at elevated temperature (using burning furnace). In this test, the samples are exposed to rising temperature reached 850℃. From these tests, the relationships between the load and mid-span deflection as well as the relations between the fire-time and mid-span deflection are measured. The results showed that the addition of steel fibers and fly ash particles will enhance the flexural behavior of concrete slabs. The highest increase in ultimate load compared to the reference slab was (28.31%) at the volume ratio 1.25% of the steel fibers and 25% of the fly ash at normal temperatures , And the rate of increase of the deflection with fire time was the lowest increase rate is 14.1% at the volume of 1.25% of steel fibers and the proportion of weight 20% of fly ash at high temperature.