Miracle-dz/UniFAR-FTUs huggingface dataset:
WoM Role on The Tourist Attraction Image and Re-visit Intention

As an educational tourist attraction, the Zoology Museum can give visitors memorable experiences and help managers evaluate and improve their operations. This study aims to analyze the direct impact of word-of-mouth into tourist attraction image and re-visit intention. This study used the purposive sampling method and quantitative approach to evaluate reflective indicators and the relationship between variables. Google Forms and surveys were used to get data from a sample of 258 respondents and 30 were first tested for validity and reliability to ensure the analysis was continued. Data processing used SEM PLS 3.0 software. The result indicates that word-of-mouth significantly increases re-visit intention. The results show that tourist attraction images significantly increase re-visit intention, including word-of-mouth as a mediator. Word-of-mouth is pivotal in the tourism industry, and this study underscores its merits for visitors and management. By incorporating sustainable practices into the marketing process, the management of the Zoology Museum can distinguish its services and products and cultivate a robust brand identity. The findings of this study indicate a positive and substantial impact of the tourist attraction's image on re-visit intention. At the same time, word-of-mouth also significantly influences re-visit intention
Eating Habits and Nutritional Status of Adolescents and Young Adults in Tertiary Institutions in Port Harcourt Metropolis

University students tend to have poor eating practices which are related to nutritional status. The objective of this study was to assess the eating habits and nutritional status of adolescents and young adults in tertiary institutions in Port Harcourt metropolis. The study adopted a cross-sectional descriptive design. The population consisted of adolescents and young adults in tertiary institutions in Port Harcourt aged 17-25 years. A multistage sampling technique was used to draw a sample size of 296 respondents from the study. Data were obtained using a three-part questionnaire (socio-demographic profile, eating habits, and anthropometric parameters). The data were statistically analyzed using frequency and percentage and findings were presented on charts and tables. Females constituted 64.86% of respondents with about 83.78% of the respondents within the ages of 21-25. Most students (78.38%) reported taking one meal a day with breakfast being the most skipped meal. Most students (56.76%) eat in the cafeteria and 72.97% ate late. Snacking was common among these students as 75.67% admitted consuming snacks 1-3 times, 3-5 times or more than 5 times weekly. Weekly intake of fish and meat, and fruits and vegetables were high (83.49% and 81.09% respectively). Among the respondents, 20(6.76%) were underweight and 99(33.49%) were obese. About half (147) of the respondents (49.54%) had normal weight while 30(10.21%) were overweight. Frequency of consumption, fruit and vegetable consumption, meat and fish intake, fast food consumption, and breakfast skipping were related to nutritional status. Overall, the results revealed that the majority of the students had poor eating habits. This suggests the need to increase nutritional counselling on healthy eating habits in universities and to take appropriate interventions to improve nutritional status among university students.
Widening of the Hadley Cell from Last Glacial Maximum to Future Climate

AbstractThe Hadley cell (HC) change from paleoclimate to future climate is examined by comparing coupled model simulations archived for the Paleoclimate Modeling Intercomparison Project phase 3 (PMIP3) and phase 5 of the Coupled Model Intercomparison Project (CMIP5). Specifically, HC width and strength are evaluated using 100-yr equilibrium simulations for the Last Glacial Maximum (LGM), preindustrial (PI), and extended concentration pathway 4.5 (ECP4.5) conditions. Where available, ECP8.5 simulations are also examined to increase the sample size. All models show a systematic widening of the HC from the LGM to the PI and to the ECP4.5 and ECP8.5 simulations. Such widening, which is found in both hemispheres with more robust change in the Southern Hemisphere (SH) than in the Northern Hemisphere (NH), is significantly correlated with global-mean surface air temperature change and the associated static stability change in the subtropics. Based on the zero-crossing latitude of 500-hPa mass streamfunction, abo.
Tumor cell stemness in gastrointestinal cancer: regulation and targeted therapy

The cancer stem cells are a rare group of self-renewable cancer cells capable of the initiation, progression, metastasis and recurrence of tumors, and also a key contributor to the therapeutic resistance. Thus, understanding the molecular mechanism of tumor stemness regulation, especially in the gastrointestinal (GI) cancers, is of great importance for targeting CSC and designing novel therapeutic strategies. This review aims to elucidate current advancements in the understanding of CSC regulation, including CSC biomarkers, signaling pathways, and non-coding RNAs. We will also provide a comprehensive view on how the tumor microenvironment (TME) display an overall tumor-promoting effect, including the recruitment and impact of cancer-associated fibroblasts (CAFs), the establishment of an immunosuppressive milieu, and the induction of angiogenesis and hypoxia. Lastly, this review consolidates mainstream novel therapeutic interventions targeting CSC stemness regulation.
Dual E × B flow responses in the dayside ionosphere to a sudden IMF By rotation

We report for the first time a dual transition state in the dayside ionosphere following a sudden rotation of the interplanetary magnetic field (IMF) in the upstream magnetosheath from IMF By < 0 to By > 0 during Bz < 0. E × B drifts respond with different time delays in the dayside auroral zone and high‐latitude polar cap with an initial 11 min transition state of oppositely directed E × B drifts coexisting at these locations. This is followed by a 6–8 min rotation of lower latitude E × B flow from dusk to dawn. We propose that this sequence of events is consistent with two separate X lines coexisting on the subsolar and lobe magnetopause. Time delays are proposed for merged flux of the draped preceding IMF to exit the subsolar region before the new IMF may be processed along a newly reconfigured component reconnection X line. Finally, a strong direct correlation is observed between magnetosheath plasma density and auroral zone E × B speeds.
Lung lymphatic endothelial cells undergo inflammatory and prothrombotic changes in a model of chronic obstructive pulmonary disease

The lymphatic vasculature regulates lung homeostasis through drainage of fluid and trafficking of immune cells and plays a key role in the response to lung injury in several disease states. We have previously shown that lymphatic dysfunction occurs early in the pathogenesis of chronic obstructive pulmonary disease (COPD) caused by cigarette smoke (CS) and that this is associated with increased thrombin and fibrin clots in lung lymph. However, the direct effects of CS and thrombin on lymphatic endothelial cells (LECs) in COPD are not entirely clear. Studies of the blood vasculature have shown that COPD is associated with increased thrombin after CS exposure that causes endothelial dysfunction characterized by changes in the expression of coagulation factors and leukocyte adhesion proteins. Here, we determined whether similar changes occur in LECs. We used an in vitro cell culture system and treated human lung microvascular lymphatic endothelial cells with cigarette smoke extract (CSE) and/or thrombin. We found that CSE treatment led to decreased fibrinolytic activity in LECs, which was associated with increased expression of plasminogen activator inhibitor 1 (PAI-1). LECs treated with both CSE and thrombin together had a decreased expression of tissue factor pathway inhibitor (TFPI) and increased expression of adhesion molecules. RNA sequencing of lung LECs isolated from mice exposed to CS also showed upregulation of prothrombotic and inflammatory pathways at both acute and chronic exposure time points. Analysis of publicly available single-cell RNA sequencing of LECs as well as immunohistochemical staining of lung tissue from COPD patients supported these data and showed increased expression of inflammatory markers in LECs from COPD patients compared to those from controls. These studies suggest that in parallel with blood vessels, the lymphatic endothelium undergoes inflammatory changes associated with CS exposure and increased thrombin in COPD. Further research is needed to unravel the mechanisms by which these changes affect lymphatic function and drive tissue injury in COPD.
Statistical modelling of co-seismic knickpoint formation and river response to fault slip

Abstract. Most landscape evolution models adopt the paradigm of constant and uniform uplift. It results that the role of fault activity and earthquakes on landscape building is understood under simplistic boundary conditions. Here, we develop a numerical model to investigate river profile development subjected to fault displacement by earthquakes and erosion. The model generates earthquakes, including mainshocks and aftershocks, that respect the classical scaling laws observed for earthquakes. The distribution of seismic and aseismic slip can be partitioned following a spatial distribution of mainshocks along the fault plane. Slope patches, such as knickpoints, induced by fault slip are then migrated at a constant rate upstream a river crossing the fault. A major result is that this new model predicts a uniform distribution of earthquake magnitude rupturing a river that crosses a fault trace and in turn a negative exponential distribution of knickpoint height for a fully coupled fault, i.e. with only co-seismic slip. Increasing aseismic slip at shallow depths, and decreasing shallow seismicity, censors the magnitude range of earthquakes cutting the river towards large magnitudes and leads to less frequent but higher-amplitude knickpoints, on average. Inter-knickpoint distance or time between successive knickpoints follows an exponential decay law. Using classical rates for fault slip (15 mm year−1) and knickpoint retreat (0.1 m year−1) leads to high spatial densities of knickpoints. We find that knickpoint detectability, relatively to the resolution of topographic data, decreases with river slope that is equal to the ratio between fault slip rate and knickpoint retreat rate. Vertical detectability is only defined by the precision of the topographic data that sets the lower magnitude leading to a discernible offset. Considering a retreat rate with a dependency on knickpoint height leads to the merging of small knickpoints into larger ones and larger than the maximum offset produced by individual earthquakes. Moreover, considering simple scenarios of fault burial by intermittent sediment cover, driven by climatic changes or linked to earthquake occurrence, leads to knickpoint distributions and river profiles markedly different from the case with no sediment cover. This highlights the potential role of sediments in modulating and potentially altering the expression of tectonic activity in river profiles and surface topography. The correlation between the topographic profiles of successive parallel rivers cutting the fault remains positive for distance along the fault of less than half the maximum earthquake rupture length. This suggests that river topography can be used for paleo-seismological analysis and to assess fault slip partitioning between aseismic and seismic slip. Lastly, the developed model can be coupled to more sophisticated landscape evolution models to investigate the role of earthquakes on landscape dynamics.
Mangrove Response to Land Use Change in Estuaries along the Semiarid Coast of Ceará, Brazil

ABSTRACT Godoy, M.D.P.; Meireles, A.J.A. , and Lacerda, L.D. , 2018. Mangrove response to land use change in estuaries along the semiarid coast of Ceará, Brazil. Mangroves cover an estimated area of approximately 12 to 20 million ha worldwide and serve as protection for the coastline from erosion and flooding. Nearly 70 mangrove species are considered endangered and could disappear in the next decade, which would have devastating economic and environmental consequences for coastal communities because of their ecological and economic importance. The annual rate of disappearance of coastal ecosystems is four times greater than the rate of the disappearance of rain forests. Mangroves suffer great pressure from the rapid conversion of forests into agricultural and urban areas, and, in these scenarios, climate change promotes specific pressures on mangroves and may increase the effects of anthropogenic activities. The focus of this study was to map the changes in mangrove areas in six river estuaries in Ceará, northeastern Brazil, between the years 1992 and 2011 and identify the main drivers of these changes. The results showed an increase in mangrove areas of five estuaries, while one estuary showed a decrease in mangrove area. Changes in river output capacity and sediment accumulation in the estuaries were associated with dam construction in the watersheds and can be responsible for new upstream mangrove areas in newly formed islands and along river banks. Abandoned saltpans also contributed to expansion of the mangrove areas. Deforestation for the construction of shrimp farms was the main cause of decreases in mangrove area, especially in the Pirangi estuary.
El Niño-Induced Drought Impacts on Reservoir Water Resources in South Africa

The ENSO phenomenon is associated with below average rainfall and influences the climate regime of southern Africa. With the advent of climate change, drought frequencies and magnitudes have worsened in the developing world and this in turn negatively impacts the natural environment and communities’ livelihoods. This study evaluated the relationship between El Niño-induced drought and reservoir water levels over the Albasini Dam Catchment (ADC) areas in Limpopo Province, South Africa. Standardised indices (i.e., SPI and SSI) were used to define drought events over the study area. Mann–Kendall and Sequential Mann–Kendall were used for trends analysis as well as correlation and wavelet coherence to evaluate the relationship between variables of interest. There exists a relationship between El Niño-induced drought event and reservoir water levels. This was shown by the correlation between drought indices and reservoir water levels with the coefficient of determination being stronger at the 12th timescale (i.e., 0.743 and 0.59) compared to the 6th timescale (i.e., 0.07 and 0.44) for both precipitation and streamflow indices, respectively. Wavelet analysis further showed that there existed a phased relationship between the two variables. Although there are other factors that may affect reservoir water resources, these study findings show that El Niño-induced drought also negatively affect water resources. Therefore, this study recommends the development of multidimensional and multiscale management strategies to minimise drought impacts and adaptation in the region.
Unveiling the Wrath of Erosion: Assessing the Impacts of Soil Erosion on the Coastal Region of Bangladesh

Study on soil erosion in the coastal region of Bangladesh is crucial due to its severe environmental and socio-economic impacts. Understanding erosion patterns, identifying vulnerable areas, and developing effective conservation strategies are essential to safeguard agricultural productivity, preserve coastal ecosystems, and protect the livelihoods of coastal communities. This study focuses on soil erosion in the low-lying, flood-prone coastal regions of Bangladesh. The Revised Universal Soil Loss Equation (RUSLE) technique was used to calculate soil erosion rates. The southern section of the study area, characterized by high rainfall erosivity (R) and soil erodibility (K), exhibited the highest erosion rates at 1446 t/ha/year. The region experiences significantly higher rainfall erosivity than other parts of the world. Cox’s Bazar, Chittagong, Feni, and Patuakhali receive over 3000 mm/yr of precipitation, while Teknaf and Hatiya surpass 4000 mm/yr. The vulnerability of the soft, sand-rich topsoil to water-driven gully and rill erosion contributes to the high erodibility factor. Conversely, the northwest and low-lying marshy areas exhibit low erosion rates due to the flat terrain and deposition of eroded soil mass from the hinterland. The hilly areas of Chittagong, Teknaf, and Cox’s Bazar experience above-average erosion rates. Effective soil conservation and management strategies are essential for reducing soil erosion in Bangladesh’s coastal regions, considering local environmental conditions such as precipitation and soil type. The findings of this research provide valuable insights for future studies and policies on soil erosion management in the coastal districts of Bangladesh. By guiding efficient conservation efforts, this information can help mitigate the adverse impacts of soil erosion on the environment and economy. IUBAT Review, 6(2): 1-24
Genetic Variants Linked to Myocardial Infarction in Individuals with Non-Alcoholic Fatty Liver Disease and Their Potential Interaction with Dietary Patterns

In recent studies, non-alcoholic fatty liver disease (NAFLD) has been associated with a high risk of ischemic heart disease. This study aimed to investigate a genetic variant within a specific gene associated with myocardial infarction (MI) among patients with NAFLD. We included 57,205 participants from a Korean genome and epidemiology study. The baseline population consisted of 45,400 individuals, with 11,805 identified as patients with NAFLD. Genome-wide association studies were conducted for three groups: the entire sample, the healthy population, and patients with NAFLD. We defined the p-value < 1 × 10−5 as the nominal significance and the p-value < 5 × 10−2 as statistically significant for the gene-by-nutrient interaction. Among the significant single-nucleotide polymorphisms (SNPs), the lead SNP of each locus was further analyzed. In this cross-sectional study, a total of 1529 participants (2.8%) had experienced MI. Multivariable logistic regression was performed to evaluate the association of 102 SNPs across nine loci. Nine SNPs (rs11891202, rs2278549, rs13146480, rs17293047, rs184257317, rs183081683, rs1887427, rs146939423, and rs76662689) demonstrated an association with MI in the group with NAFLD Notably, the MI-associated SNP, rs134146480, located within the SORCS2 gene, known for its role in secreting insulin in islet cells, showed the most significant association with MI (p-value = 2.55 × 10−7). Our study identifies candidate genetic polymorphisms associated with NAFLD-related MI. These findings may serve as valuable indicators for estimating MI risk and for conducting future investigations into the underlying mechanisms of NAFLD-related MI.
Possible Etiological Factors for the Development of Molar Incisor Hypomineralization (MIH) in Austrian Children

Background: Molar incisor hypomineralization (MIH) is a developmental enamel defect that primarily affects the first permanent molars and sometimes the incisors. Its increasing prevalence worldwide has raised clinical concerns, yet its exact cause remains unknown. This study aimed to assess potential factors influencing MIH development by analyzing the medical history of children aged 6 to 12 years using a questionnaire. Methods: This study included 100 children aged 6–12 years diagnosed with MIH during dental examination, and 100 age-matched children in the non-MIH (healthy) group from the Department of Pediatric Dentistry, University Clinic of Dentistry, Medical University of Vienna. The parents of the participants completed a two-page questionnaire regarding possible etiological factors of MIH. Results: The data analysis involved 100 children with MIH (mean age 8.5; ±1.3; 52% female) and 100 children in the healthy group (mean age 9.2; ±1.3; 42% female). The optimized binary logistic regression analysis revealed a significant association between MIH development and cesarean-section delivery (OR = 3; CI = [1.5–6.2]) and sixth disease (roseola) (OR = 3.5; CI = [1.5–8.0]). Conclusions: This study suggests that cesarean-section delivery and sixth disease (roseola) might increase the likelihood of MIH development in children.
The SST–Wind Coupling Pattern in the East China Sea Based on a Regional Coupled Ocean–Atmosphere Model

ABSTRACT To study the interaction between sea surface temperature (SST) and surface wind in the East China Sea (ECS), the Coupled Ocean–Atmosphere–Wave–Sediment Transport (COAWST) modelling system is used to downscale a global atmospheric reanalysis product over the study area in 2013. A singular value decomposition (SVD) method is applied to SST and surface wind speed to study their coupling relationship in the ECS. The heterogeneous correlation map indicates that the surface wind has a negative correlation with the SST, especially in the Kuroshio Current. From lead-lag correlations between the first principal component of SST and surface wind SVD (filtered using a Lanczos high-pass filter with a 90-day cut-off), a correlation of about 0.1 is found at lag −6, and a negative correlation of about −0.3 is also found around lag 1. The results indicate a negative feedback between SST and wind fluctuations at short time-scales. Air–sea heat ﬂuxes contribute little to the SST variability in the ECS section of the Kuroshio and the analysis of the mixed-layer heat budget shows that the contribution of horizontal advection is dominant in determining the intraseasonal SST signals.
North American Drought and Links to Northern Eurasia

This chapter provides an overview of the role of stationary Rossby waves in the subseasonal development of warm season drought over North America and subsequent downstream development of climate anomalies over northern Eurasia. The results are based on a case study of a stationary Rossby wave event that developed during 20 May – 15 June 1988. Simulations with the NASA Goddard Earth Observing System (GEOS-5) atmospheric general circulation model highlight the importance of the mean jet streams in guiding and constraining the path and speed of wave energy propagation. In particular, convective anomalies that developed over the western Pacific in late May (in the presence of the strong North Pacific jet) produce a predilection for persistent upper-level high anomalies over central North America about ten days later, leading to the rapid development of severe dry conditions there. There are indications of continued downstream wave energy propagation that reaches northern Eurasia about two weeks later, leading to the development of dry conditions over eastern Europe and western Russia, and cool and wet conditions over western Europe and central northern Eurasia. The results suggest that stationary Rossby waves can serve as a source of predictability for subseasonal development of droughts over North America and northern Eurasia.