Miracle-dz/UniFAR-FTUs huggingface dataset:
Circ_0007031 Serves as a Sponge of miR-760 to Regulate the Growth and Chemoradiotherapy Resistance of Colorectal Cancer via Regulating DCP1A

Background: Colorectal cancer (CRC) is a kind of malignant tumor, and the development of chemoradiotherapy resistance (CRR) increases the difficulty of its treatment. The role of circular RNAs (circRNAs) in cancer progression has been well documented. Nevertheless, the function of circ_0007031 in the growth and CRR of CRC has not been well elucidated. Methods: CRR cell lines were constructed using 5-Fu and radiation. Cell counting kit 8 (CCK8) assay was employed to measure the 5-Fu resistance and proliferation of cells. Clonogenic assay was used to evaluate the radiation resistance of cells. Also, the expression of circ_0007031 and microRNA-760 (miR-760) was determined using quantitative real-time polymerase chain reaction (qRT-PCR). The cell cycle distribution and apoptosis of cells were assessed by flow cytometry. Besides, the levels of apoptosis-related protein and mRNA-decapping enzyme 1a (DCP1A) protein were measured by Western blot (WB) analysis. Further, dual-luciferase reporter assay and RNA immunoprecipitation (RIP) assay were used to confirm the interaction between miR-760 and circ_0007031 or DCP1A. In addition, animal experiments were performed to evaluate the function of silenced circ_0007031 on the 5-Fu and radiation resistance of CRC tumors. Results: Circ_0007031 expression was markedly increased in CRC tissues and cells, especially in CRC resistant cells. Circ_0007031 knockdown hindered proliferation, induced cell cycle arrest in the G0/G1 phase, enhanced apoptosis, and lowered the CRR of CRC resistant cells. Further, miR-760 could be targeted by circ_0007031, and its inhibitor could reverse the inhibition effect of circ_0007031 knockdown on the growth and CRR of CRC resistant cells. Moreover, DCP1A was a target of miR-760, and its overexpression could invert the suppression effect of miR-760 overexpression on the growth and CRR of CRC resistant cells. Circ_0007031 silencing could enhance the sensitivity of CRC tumors to 5-Fu and radiation to markedly reduce CRC tumor growth in vivo. Conclusion: Circ_0007031 might play a positive role in the CRR of CRC through regulating the miR-760/DCP1A axis, which might provide a new approach for treating the CRR of CRC.
Edinburgh Research Explorer The role of siblings in talent development

of social networks that facilitate or inhibit this the its focus from parents to the role of of Analysis the of the sibling relationship that may or inhibit empirically role that siblings can play in talent development. Thirdly, strategies are proposed to support practitioners identify speciﬁc sibling characteristics, alongside recommendations for how the relationship can be utilized within both the formal and informal environments by coaches and psychologists. Finally, and crucially, important implications of these characteristics are considered to support effective coach and sport psychologist decision making.
Recruitment During Local Inflammation as the Major Mechanism for Leukocyte Resident Cell Chemokine Expression Serves

The mechanistic relationships between initiating stimulus, cellular source and sequence of chemokine expression, and leukocyte recruitment during inﬂammation are not clear. To study these relationships in an acute inﬂammatory process, we challenged a murine air pouch with carrageenan. A time-dependent increase in TNF- (cid:1) , monocyte chemottractant protein-1 (MCP-1), mac-rophage-inﬂammatory protein-1 (cid:1) (MIP-1 (cid:1) ), RANTES, KC, and MIP-2 was found in the exudates preceding cell recruitment, but displaying different kinetic proﬁles. Air pouches generated for 2, 6, or 9 days before initiating inﬂammation demonstrated a proportional increase in the number of cells lining the cavities. Two hours after carrageenan stimulation, the synthesis of TNF- (cid:1) and all chemokines but RANTES increased in proportion to the lining cellularity, although no differences in inﬁltrating leukocytes were found, suggesting that the early source of these mediators is resident cells. To assess the contribution of neutrophils to chemokine synthesis at later time points, we used neutropenic animals. Neutrophil depletion caused a decrease in TNF- (cid:1) (51%), KC (37%), MIP-1 (cid:1) (30%), and RANTES (57%) levels and a 2-fold increase in monocytes 4 h after challenge. No effect on MIP-2 and MCP-1 levels was observed. The selective blockade of CXCR2 or CCR1 inhibited neutrophil recruitment by 74% and 54%, respectively, without a signiﬁcant inhibition of monocytes. A differential effect on TNF- (cid:1) and MCP-1 levels was observed after
Nostalgia’s Place among Self-Relevant Emotions [This manuscript was accepted for publication in Cognition and Emotion ]

How is nostalgia positioned among self-relevant emotions? We tested, in six studies, which self-relevant emotions are perceived as most similar versus least similar to nostalgia, and what underlies these similarities/differences. We used multidimensional scaling to chart the perceived similarities/differences among self-relevant emotions, resulting in two-dimensional models. The results were revealing. Nostalgia is positioned among self-relevant emotions characterized by positive valence, an approach orientation, and low arousal. Nostalgia most resembles pride and self-compassion, and least resembles embarrassment and shame. Our research pioneered the integration of nostalgia among self-relevant emotions.
Nanofios de ZnO Growth, Structural and Optical Characterization of ZnO Nanowires

Zinc oxide nanowires have been grown on alumina substrate by thermal evaporation of zinc powder in the presence of oxygen flow. The growth was performed at ambient pressure and without the use of foreign catalyst. Temperature gradient between the source material and substrate, in the favourable growth temperature region, was identified as key factor determining the yield and size of the nanowires. Scanning electron microscopy (SEM) observation showed that the as-grown sample consists of bulk ZnO crystal on the substrate surface with nanowires growing from this base. Growth mechanism of the observed morphology is suggested to be governed by the change of zinc vapour supersaturation during the growth process. X-ray diffraction (XRD) measurement was used to identify the hexagonal crystalline phase of the nanowires. Optical properties of the nanowires were investigated using Raman scattering and photoluminescence (PL). The appearance of dominant, Raman active E2 (high) phonon mode in the Raman spectrum has confirmed the good cristallinity with wurtzite hexagonal phase of the nanowires. With above bandgap excitation the low temperature PL recombination is dominated by sharp donor bound exciton luminescence at ~3.37 eV. Free exciton emission is also seen at low temperature and can be observed up to room temperature. The optical data indicates that the grown nanowires have high optical quality. Growth, Structural and Optical Characterization of ZnO Nanowires iv Table of contents Acknowledgments . i Abstract . iii List of tables . vi List of figures . vi List of abbreviations. viii CHAPTER 1: Introduction. 1 1.1 Outline of the thesis. 3 CHAPTER 2: ZnO fundamental properties and nanostructures . 4 2.1 Crystal and surface structure . 4 2.2 Lattice vibration modes . 6 2.3 Energy band structure and optical properties of ZnO . 7 2.3. 1 Electronic band structure . 7 2.3. 2 Free excitons in ZnO . 9 2.3. 3 Electronic energy levels of native defects in ZnO. 13 2.4 Nanostructures of ZnO . 14 CHAPTER 3: Thermal evaporation growth of ZnO nanowires. 17 3.
Relationship Between Metabolic Syndrome and the Brazilian Workers’ Food Program in Male and Female Manufacturing Workers

Introduction: Several studies have reported increased cardiometabolic risk among workers assisted by food assistance public policies. The aim of this study was to estimate the prevalence of metabolic syndrome (MetS) and its individual components among manufacturing workers and their relationship to the Brazilian Workers’ Food Program (WFP). Methods: It was a prospective, cross-sectional, two-stage survey comparative of manufacturing workers from companies adherent and non-adherent to the WFP stratified by sector of activity and company size. The workers were interviewed in the workplace, and data on waist circumference (WC), blood pressure, and 12-hours fasting blood glucose (FBG), serum triglycerides (TG), and total and HDL-cholesterol were obtained. Mixed effects multilevel regression was used to compare WFP and non-WFP groups separately in each sex. All subjects gave written informed consent. Results: The survey included 332 workers from 16 WFP companies and 344 workers from 17 non-WFP companies. The general prevalence of MetS, according to IDF/AHA/NHLBI criteria, was high but not statistically different between sexes (39.8% in females versus 28.5% for males, p=0.16). Statistically significant differences were found between sexes in the prevalence of individual components: WC (77.8% in females versus 38.3% in males, p=0.002), TG (27.3% in females versus 40.8% in males, p=0.07), and HDL-C (52.2% in females versus 43.1% in males, p=0.05). Among males, MetS prevalence was significantly higher in the WFP group (33.0% versus 23.9%, p=0.008), and, in the individual components, the WFP group had higher prevalence of increased WC (47.0% versus 29.4%, p<0.001) and elevated FBG (8.9% versus 6.3%, p<0.001), as well as greater average levels of TG, HDL-C and FBG. Among female workers, no statistically significant differences between groups were observed in MetS prevalence and its individual components, but WFP female worker presented lower systolic and diastolic blood pressure. Conclusion: In a low-income population, male manufacturing workers participating in a food assistance program are at increased risk of MetS, an effect that was not identified among female workers.
Determinants of Board Monitoring Effectiveness in Anglo Countries in West Africa: An Empirical Investigation

This paper provides an empirical investigation into the factors influencing board monitoring function effectiveness in Anglo Countries in West Africa using Generalized Methods of Moment and other estimation techniques. Â Introducing new dimension and proxies for key board attributes ignored in prior studies, we find that board skills, independence and size play a dominant role in improving board monitoring effectiveness in these countries. However, no evidence was found for board gender diversity affecting board monitoring effectiveness. Consistent with prior studies board skills and independence by far have the strongest impact on board monitoring function effectiveness.
The Psychophysical Assessment of Hierarchical Magno-, Parvo- and Konio-Cellular Visual Stream Dysregulations in Migraineurs

Introduction: Although conscious, image-forming illusions have been noted in migraine, few studies have speci ﬁ cally sought to collectively evaluate the role of all three parallel visual processing streams in the retinogeniculostriate pathway involved with image-forming vision and their implications in the development of migraine symptoms. Methods: We psychophysically assessed the functionality of the inferred magnocellular (MC), parvocellular (PC), and koniocellular (KC) streams at different hierarchical loci across three clinical groups: individuals who experience migraine with aura (MA; n=13), experience migraine without aura (MWO; n=14), and Controls (n=15). Participants completed four experiments: Experiment 1 designed to assess retinal short-wavelength-sensitive (S-) cone sensitivities; Experiment 2 intended to measure postretinal temporal and spatiochromatic contrast sensitivities; Experiment 3 intended to assess postretinal spatiotemporal achromatic contrast sensitivities; and Experiment 4 designed to measure thalamocortical color discrimi-nations along the three cone-excitation axes. Results: S-cone de ﬁ cits were revealed with greater retinal areas being affected in MA compared to MWO participants. Findings across the four experiments suggest a prominent retinal locus of dysfunction in MA (lesser in MWO) with potential feedforward compensations occurring within the KC visual stream. Conclusion: Complex, integrative network compensations need to be factored in when considering the dysregulating in ﬂ uences of migraine along the visual pathway.
Different Clusters in Patients with Chronic Obstructive Pulmonary Disease (COPD): A Two-Center Study in Brazil

Background: Chronic obstructive pulmonary disease (COPD) has a functional definition. However, differences in clinical characteristics and systemic manifestations make COPD a heterogeneous disease and some manifestations have been associated with different risks of acute exacerbations, hospitalizations, and death. Objective: Therefore, the objective of the study was to evaluate possible clinical clusters in COPD at two study centers in Brazil and identify the associated exacerbation and mortality rate during 1 year of follow-up. Methods: We included patients with COPD and all underwent an evaluation composed of the Charlson Index, body mass index (BMI), current pharmacological treatment, smoking history (packs-year), history of exacerbations/hospitalizations in the last year, spirometry, six-minute walking test (6MWT), quality of life questionnaires, dyspnea, and hospital anxiety and depression scale. Blood samples were also collected for measurements of C-reactive protein (CRP), blood gases, laboratory analysis, and blood count. For the construction of the clusters, 13 continuous variables of clinical importance were considered: hematocrit, CRP, triglycerides, low density lipoprotein, absolute number of peripheral eosinophils, age, pulse oximetry, BMI, forced expiratory volume in the first second, dyspnea, 6MWD, total score of the Saint George Respiratory Questionnaire and packs-year of smoking. We used the Ward and K-means methods and determined the best silhouette value to identify similarities of individuals within the cluster (cohesion) in relation to the other clusters (separation). The number of clusters was determined by the heterogeneity values of the cluster, which in this case was determined as four clusters. Results: We evaluated 301 COPD patients and identified four different groups of COPD patients. The first cluster (203 patients) was characterized by fewer symptoms and lower functional severity of the disease, the second cluster by higher values of peripheral eosinophils, the third cluster by more systemic inflammation and the fourth cluster by greater obstructive severity and worse gas exchange. Cluster 2 had an average of 959±3 peripheral eosinophils, cluster 3 had a higher prevalence of nutritional depletion (46.1%), and cluster 4 had a higher BODE index. Regarding the associated comorbidities, we found that only obstructive sleep apnea syndrome and pulmonary thromboembolism were more prevalent in cluster 4. Almost 50% of all patients presented an exacerbation during 1 year of follow-up. However, it was higher in cluster 4, with 65% of all patients having at least one exacerbation. The mortality rate was statistically higher in cluster 4, with 26.9%, vs 9.6% in cluster 1. Conclusion: We could identify four clinical different clusters in these COPD populations, that were related to different clinical manifestations, comorbidities, exacerbation, and mortality rate. We also identified a specific cluster with higher values of peripheral eosinophils.
CLEP_A_273566 1183..1203

1Department of Dermatology, ChinaJapan Union Hospital of Jilin University, Changchun, Jilin, People’s Republic of China; 2Tissue Bank, China-Japan Union Hospital of Jilin University, Changchun, Jilin, People’s Republic of China Abstract: Epidemiological findings on the effects of hormones on melanoma risk have been inconsistent. We therefore conducted a meta-analysis to examine the relationship between exogenous hormonal and reproductive factors and the risk of melanoma in women. We performed a search of PubMed, Web of Science, and the China National Knowledge Infrastructure (CNKI) database through April 2020 for relevant studies. Based on heterogeneity, we performed the meta-analysis of the risk estimates using either fixed effect or random effect models. We identified 38 studies that met the analytical criteria, involving 3,571,910 participants. The results showed that long-term use of oral contraceptives (OC) may increase the risk of melanoma in women (≥5 years [pooled RR=1.18; 95% CI: 1.07– 1.31; I=0%] and ≥10 years [pooled RR=1.25; 95% CI: 1.06–1.48; I=0%]). Women who first used OC 15–19 years previously were more likely to develop melanoma (pooled RR=1.52; 95% CI: 1.03–2.24; I=0%), while the years since the last use and the age at first use were not associated with the development of melanoma in women. Hormone replacement therapy (HRT) increased the incidence of melanoma in women (pooled RR=1.12, 95% CI: 1.02–1.24; I=50%) and was especially associated with an increased risk of superficial spreading melanoma (SSM) (pooled RR=1.26; 95% CI: 1.17–1.37; I=0%), and estrogen and estradiol may be the main active agents that contribute to the increased risk of melanoma, but these results may be due to a combination of sun exposure factors. With regard to reproductive factors, decreased parity and being aged ≥20 years at first birth may be associated with an increased risk of melanoma in females, while menopausal status and age at menarche are not associated with the incidence of melanoma in females. Further large-scale prospective studies are necessary to reveal new pathophysiological mechanisms and new therapeutic targets for cutaneous melanoma.
Open collaborative innovation and digital platforms

Abstract This study uses contract theory to analyse the relationship between open collaborative innovation strategies and digital platforms. We argue that a collaborative mechanism and governance of the platform affect how operations are run and impact firm ambidexterity. We also explain how the twofold revealing strategy, both selective and free occurs via the platform and how governance positively impacts the coordination mechanism. A case study analysis on TIM OPEN draws a ground-breaking framework for future investigations. The analysis suggests that the combination of digital platform and collaborative innovation can facilitate the creative process and be a driver of operational synergies. Results confirm that the adoption of digital platforms for collaborative innovations reduces transaction costs.
Polymer solar cells: P3HT:PCBM and beyond

For the last two decades, polymer solar cells (PSCs) have been a cynosure of the photovoltaic community, as evidenced by the growing number of patent applications and scientific publications. Efforts to achieve high power conversion efficiency in PSC, propelled by advances in device architecture, material combination, and nanomorphology control, evolved into poly(3-hexylthiophene-2,5-diyl) (P3HT):phenyl-C61-Butyric-Acid-Methyl Ester (PCBM) bulk heterojunction PSCs, which had been the best seller in PSC research for a decade. Subsequently, PSC research was redirected towards the synthesis of low bandgap materials and optimization of tandem cells, which led to a power conversion efficiency of ∼13%. Even though this efficiency may not be sufficient enough to compete with that of inorganic solar cells, unique properties of PSCs, such as mass roll-to-roll production capability, as well as flexibility and lightness, suggest their niche market opportunities. In this review, an overview of developments in PSCs is.
Analysis of Static Narrowband On-Body Channel Polarization Distribution at 2.4 GHz

The polarization of on-body propagation channels has shown significant spatial selectivity and full-space distribution in numerous measurements due to the near-field characteristics and strong body scattering effect. To get a comprehensive image of such polarization distribution, in this work, we measured polarized on-body channels on static body at 2.4 GHz by monopole antennas, where standing and sitting postures are included. The polarization of the measured on-body antennas covers the full-space in Z-, H-, and V-direction relative to the skin of the body. Consequently, an extended cross-polarization discrimination (XPD) is also proposed to describe the depolarization and copolarization in the measurements. In the statistical characteristics of the channels, the V-polarization direction of the receiving antenna is more conducive for receiving signal and reducing the path losses. The results show that strong depolarization of on-body channels is more easily caused in sitting posture due to scattering effects from the legs. Simplified finite-difference-time-domain (FDTD) simulations are conducted to investigate the field polarization distribution of point sources on a static torso in cylindrical shape. The simulation results are in general consistent with the analysis of measured on-body channels.
Is Dextrose Prolotherapy Superior To Corticosteroid Injection In Patients With Chronic Lateral Epicondylitis?: A Randomized Clinical Trial

Purpose: To compare the ef ﬁ cacy of dextrose prolotherapy versus steroid injection in the treatment of patients with chronic lateral epicondylitis. Methods: Thirty subjects with chronic lateral epicondylitis were randomly assigned into two groups of hypertonic dextrose or methylprednisolone injection. Participants were assessed through Quick DASH and VAS scores, once before injection, and then after 1- and 3-months follow-up. Two patients were excluded due to not completing the follow-up timepoints. Results: In both groups VAS scores revealed signi ﬁ cant improvement during the ﬁ rst month follow-up [mean difference (MD) = 1.9±3.3, versus 1.5±1.9 for the prolotherapy and steroid groups, respectively]. This declining trajectory continued at the third month visit in the prolotherapy group and MD reached 4.4±2.9, while it did not change remarkably in the steroid group (MD=1.9±3.4). In fact, comparing VAS scores between the 1st- and 3rd-month time points did not reveal a signi ﬁ cant improvement in the steroid group ( p =0.6). Also, the Quick DASH index showed a similar pattern and improved remarkably in both groups during the ﬁ rst visit. However, only the ef ﬁ cacy in the prolotherapy group persisted after 3-month follow-up (MD = 9.5±21.6, p =0.044). One month after injections no preference between the two interventions was observed ( p =0.74 for VAS and 0.14 for Quick DASH score). However, the 3rd-month follow-up revealed a meaningful superiority ( p =0.03 for VAS and p =0.01 for Quick DASH score) favoring the prolotherapy method. Conclusion: Both methods were proven to be effective in the short-term treatment of chronic lateral epicondylitis, but dextrose prolotherapy seems to be slightly more ef ﬁ cacious than steroid injection over a longer period.