Miracle-dz/UniFAR-FTUs huggingface dataset:
The role of the primary motor cortex in motor imagery: A theta burst stimulation study

Abstract While mentally simulated actions activate similar neural structures to overt movement, the role of the primary motor cortex (PMC) in motor imagery remains disputed. The aim of the study was to use continuous theta burst stimulation (cTBS) to modulate corticospinal activity to investigate the putative role of the PMC in implicit motor imagery in young adults with typical and atypical motor ability. A randomized, double blind, sham‐controlled, crossover, offline cTBS protocol was applied to 35 young adults. During three separate sessions, adults with typical and low motor ability (developmental coordination disorder [DCD]), received active cTBS to the PMC and supplementary motor area (SMA), and sham stimulation to either the PMC or SMA. Following stimulation, participants completed measures of motor imagery (i.e., hand rotation task) and visual imagery (i.e., letter number rotation task). Although active cTBS significantly reduced corticospinal excitability in adults with typical motor ability, neither task performance was altered following active cTBS to the PMC or SMA, compared to performance after sham cTBS. These results did not differ across motor status (i.e., typical motor ability and DCD). These findings are not consistent with our hypothesis that the PMC (and SMA) is directly involved in motor imagery. Instead, previous motor cortical activation observed during motor imagery may be an epiphenomenon of other neurophysiological processes and/or activity within brain regions involved in motor imagery. This study highlights the need to consider multi‐session theta burst stimulation application and its neural effects when probing the putative role of motor cortices in motor imagery.
Validation of host cerebrospinal fluid protein biomarkers for early diagnosis of tuberculous meningitis in children: a replication and new biosignature discovery study

Abstract Purpose: The diagnosis of tuberculous meningitis (TBM) in children is often delayed due to diagnostic difficulties. New tools are urgently needed to improve the diagnosis of the disease in this vulnerable group. The present study aimed to validate the accuracy of recently identified host cerebrospinal (CSF) biomarkers as candidates for the diagnosis of TBM in children. Materials and methods: We collected CSF samples from 87 children aged 3 months to 13 years, that were consecutively admitted at a tertiary hospital in Cape Town, South Africa, on suspicion of having TBM. We evaluated the concentrations of 67 selected host protein biomarkers using a multiplex platform. Results: Previously identified 3-marker (VEGF-A + IFN-γ + MPO) and 4-marker (IFN-γ + MPO + ICAM-1 + IL-8) signatures diagnosed TBM with AUCs of 0.89 (95% CI, 0.81–0.97) and 0.87 (95% CI, 0.79–0.95) respectively; sensitivities of 80.6% (95% CI, 62.5–92.5%) and 81.6% (95% CI, 65.7–92.3%), and specificities of 86.8% (71.9–95.6%) and 83.7% (70.4–92.7%) respectively. Furthermore, a new combination between the analytes (CC4b + CC4 + procalcitonin + CCL1) showed promise, with an AUC of 0.98 (95% CI, 0.94–1.00). Conclusions: We have shown that the accuracies of previously identified candidate CSF biomarkers for childhood TBM was reproducible. Our findings augur well for the future development of a simple bedside test for the rapid diagnosis of TBM in children.
Something’s Gotta Give: The Relationship Between Time in Eldercare, Time in Childcare, and Employee Wellbeing

While existing research indicates that “sandwiched” employees (those with both childcare and eldercare demands) have lower wellbeing than employees with only eldercare demands, there is little understanding how childcare and eldercare demands interact to create those differences. Drawing on two studies, we hypothesize childcare demands amplify the negative impact of eldercare demands on wellbeing. Study 1 operationalizes childcare as a dichotomous variable (i.e., has childcare or not), and examines the relationship between hours per week in eldercare and wellbeing for two groups of employees: those with eldercare and those in the sandwich generation. Study 2, which operationalizes childcare as a continuous variable (i.e., hours in childcare per week), explores how time in childcare moderates the relationship between time in eldercare and wellbeing. Findings show time in eldercare is negatively associated with wellbeing, and the impact of childcare on the relationship between time in eldercare and wellbeing is dependent on how one operationalizes wellbeing and childcare constructs.
How Parents’ Ideals are Offset by Uncertainty and Fears: A Systematic Review of the Experiences of European Parents regarding the Sexual Education of Their Children

ABSTRACT Parents have a critical role to play in the sexual education of their children. We conducted a systematic review of studies assessing the experiences of parents regarding the role they play in the sexual education of their children. We included qualitative, quantitative, and mixed methods studies conducted among parents in Europe. We searched PubMed, Web of Science and Scopus, and screened 20,244 unique records. Forty-nine studies enrolling 18,083 unique parents met inclusion criteria. The studies show that parents have ideals regarding the sexual education of their children that center around the importance of trust, open conversations, and honesty. However, challenges and concerns, related to parents’ and children’s gender, children’s age, children’s specific situations, and limited parental knowledge and communication skills prevented them from living up to these ideals. Parents pointed to the role of other institutions as ways to support and strengthen parents’ contributions to the sexual development of their children. We conclude that parents may require guidance and support to identify what is appropriate sexual education for their children, based on age, gender, and other characteristics, how to provide appropriate sexual education, and to strengthen their sexual communication skills and knowledge of contemporary sexual health issues.
Immunogenicity and Safety of Standard and Third‐Dose SARS–CoV‐2 Vaccination in Patients Receiving Immunosuppressive Therapy

Immunogenicity and safety following receipt of the standard SARS–CoV‐2 vaccination regimen in patients with immune‐mediated inflammatory diseases (IMIDs) are poorly characterized, and data after receipt of the third vaccine dose are lacking. The aim of the study was to evaluate serologic responses and adverse events following the standard 2‐dose regimen and a third dose of SARS–CoV‐2 vaccine in IMID patients receiving immunosuppressive therapy.
Social disparities in students’ intention to enter higher education during the COVID-19 pandemic

Research consistently shows that students from academic households are more likely to enter higher education than students from non-academic households. These inequalities are only secondarily due to differences in performance (i.e., primary effects), but mostly due to students’ decision making behavior (i.e., secondary effects). The relative share to which primary effects and secondary effects mediate the effect of students’ educational background on their intention to enter higher education is affected by external conditions. One significant external influence that may have had an impact on social disparities in students’ educational choices is the COVID-19 pandemic. Herein, we present data from N = 596 upper secondary students (41.6% from non-academic households) that were collected in Germany in April 2021. Building on rational choice theory, we scrutinized students’ expected benefits (i.e., employment prospects and personal significance), costs (i.e., direct costs and opportunity costs), and subjective probability of success in pursuing higher education as important psychological pillars for their intention to enter higher education. Results show that about 14% of social differences in students’ intention to enter higher education were due to primary effects, whereas almost 77% were explained by secondary effects. Specifically, we found that differences in the evaluation of benefits most strongly contributed to social inequalities in students’ intention to enroll in higher education. Compared to research on pre- COVID-19 cohorts, our results point to shifts in existing patterns of inequalities in the wake of the COVID-19 pandemic.
The Presence of Clonal Hematopoiesis Is Negatively Associated with Diabetic Peripheral Neuropathy in Type 2 Diabetes

Background Clonal hematopoiesis of indeterminate potential (CHIP) has been reported to be associated with increased cardiovascular disease, aging and insulin resistance. Despite the debate of causal contribution of CHIP on metabolic diseases, we want to explore whether CHIP is related to diabetic peripheral neuropathy (DPN). Methods This study analyzed the prevalence of CHIP in patients with type 2 diabetes classified according to DPN status. Logistic regression analysis was used to evaluate the association between CHIP and DPN. Results CHIP was more prevalent in subjects without DPN than those with DPN (19.9% vs. 8.8%, respectively; P=0.013). Individuals having any CHIP, or DNA methyltransferase 3A (DNMT3A) CHIP were less likely to have any abnormality shown in DPN test; the adjusted odds ratio were 0.85 (95% confidence interval [CI], 0.73 to 1.00) and 0.70 (95% CI, 0.56 to 0.89), respectively. Interestingly, DNMT3A CHIP showed the negative association, but Tet methylcytosine dioxygenase 2 (TET2) CHIP showed the positive association with abnormal feet electrochemical skin conductance level. Conclusion On the contrary to expectations, CHIP was negatively associated with DPN. Functional linking between the mutation in hematopoietic cells and DPN, and the opposite role of DNMT3A and TET2 should be investigated.
The Level of Application of Total Quality Management (TQM)Requirements in Algerian Higher Education Institutions Case Study of University El Hadjlakhdar Batna in Algeria

The study aimed to identify the extent of the application of total quality management requirements from the viewpoint of teachers at the university of batna in Algeria, and to identify differences in attitudes resulting in a number of demographic changes, and thus develop a questionnaire distributed to a targeted sample of teachers, has been analyzing data using statistical analysis package (SPSS) and based on appropriate statistical indicators and tests. We have concluded that the application of total quality management requirements at the university of batna as members of the Teachers is a medium was also a substantial differences in attitudes of teachers, so they must work continuously on the development of the climate that fosters positive direction and senior management commitment to the participatory processes and continuous improvement.
THE WIENER INTEGRAL OVER PATHS IN ABSTRACT WIENER SPACE

We snmmarize the properties of Wiener measure on the space of continuous functions y on [a, b] which values in an abstract Wiener space B such that y(a) = o. Such properties are very briefly in the literature [6] with the exception of scaling properties. Since the scaling properties will be especially impotant to us, we consider them in some detail. The main results of this paper is in section 3 where we study the operator-valued function space integral of functionals on Co(B). Our results are related to works of Johnson and Lapidus (see section 2 and 3 of [4]) except that we work in more complicated Wiener space Co(B) instead of ordinary Wiener space. On the other hand, our results are restrict to real . \ > 0 whereas the results of [4] are not. We express the operator which are the values of the function space integrals as generalized Dyson series much as in [4]. And these series can be viewed as disentangling the operator's involved. For a discussion of disentangling, see [4}.
Multi-dimensional Transcriptional Remodeling by Physiological Multi-dimensional Transcriptional Remodeling by Physiological Insulin In Vivo Insulin In Vivo Let us know how access to this document benefits you.

pre-complexed fatty acid-free bovine serum albumin (FAF-BSA) BSA-only for h. Total intracellular triglycerides were measured by an enzymatic plate-based assay (Pointe Scientiﬁc) normalized to For FAO, were serum-starved of FAF-BSA for followed by with media (FAIM) m M palmitic conjugated with FAF-BSA plus in the presence of 0.1 14 C palmitic (Perkin FAO as the fraction 14 2 ﬁlter protein Before 14 assayed for b -hydroxybutyrate levels ﬂuorimetric method according serum-starved for and incubated with FAIM containing 200 m M palmitic acid conjugated FAF-BSA plus 30 min in the presence of 0.1 m Ci 14 C palmitic acid. Fatty acid uptake was interpreted as pro-tein-normalized counts from cell lysates.
Dual Frequency Ultrasound-Assisted Esterification of Palm Empty Fruit Bunch Oil with Zeolite Heterogeneous Acid Catalyst

Biodiesel production from waste-or by-product oils having high free fatty acid (FFA) contents is required oil pretreatment. Esterification has been used to reduce FFA contents of crude oils prior to transesterification. In this present work, palm empty fruit bunch (EFB) oil which is a by-product from the palm oil industry was used as feedstock for biodiesel production. The EFB oil has very high FFA contents. Thus, esterification of the oil was carried out. The esterification was enhanced by dual frequency ultrasound waves (28 kHz + 40 kHz). Zeolite was used as a heterogenous acid catalyst. Methanol to oil (M:O) molar ratio, catalyst loading, and reaction were main factors affecting on the process and were investigated using central composite design (CCD) of experiment. Response surface methodology (RSM) was used to optimise these parameters. The results showed that at the optimised condition of 12:1 M:O molar ratio, 11.36 %wt catalyst loading and 60 min of reaction time, the FFA conversion was highest at 91.69% compared with the predicted value of 93.56% which was only 1.99% difference between tested and predicted values.
Assessing Improvised Equipment in Physics Laboratory and its Implications for Utilization and Management of Teaching and Learning Resources

The focus of the paper was on assessing improvised equipment in physics laboratory and its implications for utilization and management of teaching and learning resources. A total of 45 teachers teaching in secondary and tertiary schools in Kogi State took part in the survey study. A Likert scale type of questionnaire based on the 10 identified Suitability Assessment Factors (SAF) grouped into 5 lower orders and 5 higher orders SAF was used for data collection. It was face validated and trial tested with a test retest reliability coefficient of 0.76. Data were analyzed using percentage, t-test and chi square (x2) statistical techniques and the result showed that: (1) Ten SAF was identified with percentage suitability rating range of 60 to 100. These (SAF) were grouped into 5 lower orders and 5 higher orders SAF. (2) There was a significant difference between the teachers rating of some improvised physics equipment in the lower order SAF and the higher order SAF. (3) The teachers’ total rating for lower and higher order SAF was contingent upon the areas or fields of improvisation in physics. Recommendations were advanced for effective assessment, utilization and management of improvised teaching and learning resources in physics.
Adsorption and Inhibition Performance of Arachis hypogaea Extracts on 316L Steel in H2SO4 Solution

The inhibitive properties of Arachis hypogaea (AH) on 316L steel in 5 M H2SO4 solution was analysed with weight loss method. The results obtained reveal the inhibitive nature of AH protection with optimum inhibition efficiency of 82.58%, after 504 h. The adsorption behaviour shows the performance of AH is due to the active bonds and functional groups. The regression values obtained was close to unity at 0.9656, obeying Langmuir adsorption isotherm. It also confirms the strong adsorption nature of organic inhibitor compounds as discussed in this research by showing excellent performance of inhibition efficiencies.
Entropy Generation Minimization for Radiative Casson Fluid Flow through Permeable Walls and Convective Heating: A Comprehensive Numerical Investigation

Entropy generation minimization is a method that helps to improve the efficiency of real processes and devices. This study investigates the heat transfer in an electrically conducting Casson fluid flow between parallel plates under the influence of thermal radiation and convective boundary conditions. The thermodynamics first and second laws were employed to examine the problem. The present study provides a fast convergent method on the finite parallel plates, namely the Optimal Homotopy Analysis method (OHAM) and Collocation Method (CM) are used to analyzes the fluid flow, heat, transport. The impacts of governing parameters on Casson flow velocity, temperature profile, local skin friction, and Nusselt number were analysed. The obtained solutions were used to determine the heat transfer irreversibility and bejan number of the model. The method employed in this paper offers excellently convergence solutions with good accuracy. The results of the computation show that the effect of thermophysical properties such as thermal radiation parameter, suction/injection parameter, magnetic field parameter, radiation parameter, and Eckert number has a significant influence on Skin friction coefficient (Cf) and local Nusselt number (Nu) when compared to the Newtonian fluid. The application of this work can be found in polymer synthesis, metallic processing, and electromagnetic crucible systems.
The Effect of the Calcined Dam’s Mud as Supplementary Cementitious Materials on Thermal Insulation

In Algeria, the calcined dam's mud is a local renewable waste that proved its use as a supplementary cementitious material (SCMs) with similar mechanical performances and better resistance to several physical and chemical attacks than Portland cement. In the same context, the main objective of the work is to evaluate the effect of this calcined mud on thermal conductivity, which was never tested. To concretize this goal, one mortar based on control cement (CEMI) and three others based on modified cement by replacing CEMI by 10% to 30% Wt rates with the calcined mud of Chorfa dam have been prepared and cured before being put to the test procedure. Compressive strength, apparent density, water absorption after immersion, and thermal conductivity at three degrees of saturation state (saturated, outdoors, and dried state) were tested. The results show that using 10% to 20% replacement rate is characterized by good free lime and calcium hydroxide consumption that produces C-S-H gel, fills pores, decreases porosity, and increases density. The thermal conductivity of mortars based on the calcined mud in all states was lower compared than the control mortar, at saturated state by 16.28%, 17.83%, and 18.60% for the mortars 10%, 20%, and 30% (of cement replacement) respectively, at outdoors state by 5.5%, 4%, and 17.5% and dry state with 8.39%, 20.65%, and 38.07%. 10% to 20% mud replacement is beneficial for use in masonry and plastering wall applications of a building's envelope. 30% replacement rate can be developed and used in environments with minimal class expositions.
Atraumatic spontaneous splenic rupture in a female COVID-19 patient

Abstract Coronavirus disease (COVID-19), an infection caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has severely ravaged the world since the end of 2019. Although most cases range from mild to severe with primarily respiratory symptoms, there have been some unusual clinical presentations, one of which is described in this case report. A 30 year-old woman with no significant medical history presented to the emergency department (ED) in October 2020 with sudden onset of severe left upper and lower abdominal pain. Her initial triaged blood pressure was 70 mmHg systolic, associated with mild tachycardia. Her beta human chorionic gonadotropin (beta-hCG) was negative, and her initial hemoglobin was 9.3 g/dL. A bedside ultrasound (US) was immediately performed, which showed moderate free fluid in the pelvis as well as in the right and left upper quadrants of the abdomen. She was stabilized with a fluid bolus and later underwent a CT scan of the abdomen and pelvis, which showed an apparent grade III splenic laceration without active extravasation. The patient underwent a successful embolization procedure by interventional radiology (IR) and was discharged from the hospital 2 days later. The initial medical workup included a positive polymerase chain reaction (PCR) COVID-19 test but included no other findings that could serve as a cause for her spleen to spontaneously rupture. The purpose of this case report is to illustrate and make other clinicians aware of unusual potential complications and clinical presentations of COVID-19. The condition of spontaneous splenic rupture (SSR) is an uncommon but an emergent differential diagnosis in an otherwise healthy person with potential drastic outcomes. A careful approach in the management and care of these patients is warranted. This is one of a handful of case reports on SSR secondary to COVID-19 to the best of our knowledge.
STRATEGIC PRODUCTION LINE SYNCHRONISATION

A study was conducted at the sole global producer of suspension struts for a particular vehicle manufacturer. This supplier is currently able to meet customer demand. However, it does so because of a large finished goods and work-in-progress (WIP) inventory. The plant operates two production processes that are separated by a large buffer of WIP, which essentially decouples the production processes. This study aimed to reduce this WIP buffer; this would require the processes to become synchronised, bearing in mind that the reliability of delivery should not decrease. A tool that considers time, quality, and machine capacity was developed to assess the impact of line synchronisation on company performance figures. It was found that line synchronisation produced several benefits for the supplier, including batch size reduction, lower inventory levels, and associated shorter lead times. This further allowed the supplier to improve flow in the plant by introducing a pull system. Improved visual oversight could lead to further improved problem-solving and innovation.