Miracle-dz/UniFAR-FTUs huggingface dataset:
Molecular characterization and incidence of new tospovirus: Soybean Vein Necrosis Virus (SVNV) in Egypt.

Field survey study was conducted season (2017). Soybeans and weeds were weekly sampled randomly. Thrips adults were identified and counted. Detection of the virus isolate and the natural incidence was determined using; Mechanical transmission, host range, DAS-ELISA, RT-PCR. The natural incidence thrips individuals was detected depending on the SVNV% in thrips individuals and weeds hosts. Ten thrips species were associated with soybean plants in the field. The most abundant species was T. tabaci, average 256.5 average no.of individuals, followed by F. occidentalis (142.5 average no. of individuals), then N. variabilis (86.6/ average no. of individuals). Fourteen thrips species occurred on 5 legumes field crops and 41 weed plant species within soybean field. The highest average number 40.6. of individuals were recorded on Ammi majus. While the lowest one 3.3 average no. of individuals were on Urtica urens. Only 21diagnostic plant species were susceptible to infection with SVNV. G. max and Vigna radiate, were the highest percentage of infection 80% followed by V. unguilata & N. benthamiana, 75%. Egyptian isolate of Soybean vein necrosis virus (SVNV) in this study showed a high degree of similarity and it is closely related to TSWV from Egypt (DQ479968) and TCSV from USA (KY820965) with nucleotide sequence identity of 78%. Four thrips species transmitted SVNV (F. fusca 4.0%, F. schultzei 4.3%, F. tritici 3.3% and N. variabilis 68.0% transmission). Both C. phaseoli and M. sjostedti can acquire the virus but unable to transmit it. The following species; T. tabaci, F. occidentalis, S. dorsallis and T. palmi cannot acquire or transmit SVNV. The incidence of SVNV in the field started by the end of July then increased gradualy from 12.7 to 71.3% by the end of the season. In conclusion, few thrips individuals invaded soybean crops are enough to transmit high rate of SVNV within the crop. Furthermore, several vector species are also abundant on weeds, which are the major sources of soybean viruses transmitted to the crops. This information might be important for control and reduce the incidence of SVNV infection.
IN VESTIGATING PROJECTS' WORKING ENVIRONMENT EFFECTS ON LABOUR PRODUCTIVITY: PERCEPTIONS OF IRANIAN ROAD CONTRACTORS' MANAGERS

Delays and budget overruns in construction projects have been a lifelong problem in many developing countries including Iran. Previous studies within Iranian construction context have wholeheartedly acknowledged the contribution of low labour productivity to the foregoing challenges rampant in the Iranian construction industry. In this context, identifying the factors adversely affecting labour productivity seems to be the first step towards resolving the aforementioned issues. Taking into account the crucial role of road construction projects in Iran as a developing country, this paper presents the results of one of the first studies conducted in Iranian road projects aiming at identifying and ranking the major factors influencing the labour productivity of road contractors. The literature review findings established that one of the key aspects of a project affecting labour productivity concerns the project’s nature and working environments. Hence, the impacts levels of 8 overarching factors associated with working environments in road construction projects were investigated through conducting a questionnaire survey eliciting the viewpoints of CEOs of 60 contractor companies active in road construction projects in Iran. The outcomes ascertained the main factors pertaining the projects nature and environment acting as the determinants of labour productivity in road contractor companies. The primary factors were ranked as: (1) procurement policies, (2) weather conditions, (3) technologies deployed, (4) quality auditing procedures, (5) congestion and overcrowding on the site, (6) complexity of the projects, (7) site geographical conditions, and (8) reworks. The findings of the study would contribute to the body of construction management knowledge by highlighting the factors affecting labour productivity as the prerequisite for any attempt geared towards improving labour productivity Proceedings of the 4th International Conference on Engineering, Project, and Production Management (EPPM 2013)
Factors Associated with 90-Day Mortality in Invasively Ventilated Patients with COVID-19 in Marseille, France

Objectives: To describe clinical characteristics and management of intensive care units (ICU) patients with laboratory-confirmed COVID-19 and to determine 90-day mortality after ICU admission and associated risk factors. Methods: This observational retrospective study was conducted in six intensive care units (ICUs) in three university hospitals in Marseille, France. Between 10 March and 10 May 2020, all adult patients admitted in ICU with laboratory-confirmed SARS-CoV-2 and respiratory failure were eligible for inclusion. The statistical analysis was focused on the mechanically ventilated patients. The primary outcome was the 90-day mortality after ICU admission. Results: Included in the study were 172 patients with COVID-19 related respiratory failure, 117 of whom (67%) received invasive mechanical ventilation. 90-day mortality of the invasively ventilated patients was 27.4%. Median duration of ventilation and median length of stay in ICU for these patients were 20 (9–33) days and 29 (17–46) days. Mortality increased with the severity of ARDS at ICU admission. After multivariable analysis was carried out, risk factors associated with 90-day mortality were age, elevated Charlson comorbidity index, chronic statins intake and occurrence of an arterial thrombosis. Conclusion: In this cohort, age and number of comorbidities were the main predictors of mortality in invasively ventilated patients. The only modifiable factor associated with mortality in multivariate analysis was arterial thrombosis.
Botulinum Toxin Therapy: A Series of Clinical Studies on Patients with Spasmodic Dysphonia in Japan

Spasmodic dysphonia (SD) is a rare voice disorder caused by involuntary and intermittent spasms of the laryngeal muscles. Both diagnosis and treatment have been controversial. Therefore, a series of clinical studies has recently been conducted in Japan. A nationwide epidemiological survey revealed that adductor SD predominated (90–95% of all cases; 3.5–7.0/100,000), principally among young women in their 20s and 30s. To facilitate early diagnosis, we created diagnostic criteria for SD and a severity grading system. The diagnostic criteria include the principal and accompanying symptoms, clinical findings during phonation, the treatment response, and the differential diagnoses. The severity grade is determined using a combination of subjective and objective assessments. Botulinum toxin (BT) injection is the treatment of choice; however, there have been few high-quality clinical studies and BT has been used off-label. We conducted a placebo-controlled, randomized, double-blinded clinical trial of BT therapy; this was effective and safe. BT treatment is now funded by the Japanese medical insurance scheme. Studies thus far have facilitated early diagnosis and appropriate therapy; they have fostered patient awareness of SD.
Cardiac safety screens: molecular, cellular, and optical advancements

Identifying cardiac safety is becoming increasingly important for new drugs under development, since it is compulsory for the approval of almost all pharmaceutical drugs. In contrast to conventional electrophysiological in vitro assays that are based on a single entity, the hERG channel, primary cardiomyocytes based readouts seem to be more comprehensive. Such an action potential readout for those cells can be performed with contact-free optical methods. Here we reveal the details of both, the optical arrangement and the procedure to screen cardiac myocytes based on naïve action potentials. Furthermore we evaluate the differences between neonatal and adult cardiac myocytes from rats based on a selection of test substances (quinidine, 4-aminopyridine and E-4031) and relate it to the human situation. Finally the results are discussed in the context of emerging genetically encoded potential sensors and latest development in optical detection technologies.
Efficacy of nanomicelle curcumin, Nigella sativa oil, and their combination on bone turnover markers and their safety in postmenopausal women with primary osteoporosis and osteopenia: A triple‐blind randomized controlled trial

Abstract Literature supports the potential effects of nanomicelle curcumin and Nigella sativa on the amelioration of osteoporosis, a health concern of postmenopausal women. This study aimed to evaluate the impacts of nanomicelle curcumin (CUR), Nigella sativa oil (NS), and their combination on bone turnover biomarkers and assess their safety. This triple‐blind randomized controlled trial was performed on 120 postmenopausal women aged 50–65 with primary osteoporosis or osteopenia. The subjects were randomly allocated to receive microcrystalline cellulose (placebo), 80 mg of CUR, 1000 mg of NS, or their combination (CUR‐NS) for 6 months. All patients were also treated with alendronate (70 mg) and calcium (500 mg), vitamin D (400 IU) supplements. The serum levels of alkaline phosphatase (ALP), osteocalcin (OC), and osteopontin (OP) were measured at the baseline and after the intervention. For safety assessment, the hepatic enzyme levels of aspartate transaminase and alanine transaminase as well as serum urea and creatinine were evaluated. ALP levels were significantly reduced in the NS (p = .029) and CUR‐NS (p = .015) groups compared with those in the placebo. After adjustment for the covariates, this effect was still significant in the CUR‐NS group (p = .004). The OC levels were decreased in the placebo, CUR, and NS groups, and the OP concentration also was attenuated in all groups through the trial. However, the intergroup differences were not significant for both biomarkers. Evaluating the key renal metabolites and hepatic enzyme levels indicated no toxicity of the administered doses. This study reveals the beneficial effects of CUR‐NS on the improvement of some bone turnover biomarkers. These compounds seem to be safe at the current dosage for supplementation in postmenopausal women.
Implementation Cost Comparison of TSN Traffic Control Mechanisms

The IEEE Time-Sensitive Networking (TSN) Task Group specifies a set of standards that enables real-time communication with predictable and bounded delays over the Ethernet. Specifically, TSN introduces a new set of so-called shapers, which regulate traffic arrival and transmission in the networks. Prominent among those are the IEEE 802.1 Qbv Time Aware Shaper (TAS) and IEEE 802.1Qav Credit-Based Shaper (CBS). Another traffic control mechanism is the IEEE 802.1Qbu Frame Preemption. Most works in the literature have focused on the quantitative performance comparison between these mechanisms. However, the discussion on how they compare in terms of implementation cost has received less attention. In this paper, we provide a comprehensive comparison of the implementation cost of the aforementioned TSN traffic control mechanisms. This comparison can help system designers in choosing which of the mechanism(s) to deploy for their applications.
SOCIAL CLASS, CONSUMPTION AND CONFLICTS: A QUALITATIVE RESEARCH ON CONSUMERS IN A WEST AFRICAN CHRISTIAN CONTEXT

The relationships between alcohol consumption and conflicts has been explored in several contexts. Little research has been conducted on the subject in Burkina Faso. The purpose of this research is to deeply investigate the relationship between social class and alcohol consumption on one hand, and alcohol consumption and household conflicts on the other in Burkina Faso where alcohol consumption is on the increase. This exploratory research is focused on the constructivist epistemological posture. A qualitative method research design is used to collect data from both primary and secondary sources for analysis. Semi-structured interview guide was used for data collection. The results show that social class moderates the relationship between alcohol consumption and conflicts, and a high relationship between alcohol consumption and household conflicts. The findings imply that there should be a rigorous segmentation and religious hyper-personalisation of the alcohol beverage market in order to meet the local Christian consumers’ core needs and real expectations. To the best of authors’ knowledge, this is an exploratory research in the West African Christianity context that shows the relationship between different social classes and alcohol consumption and conflicts. Keywords: Social class, Alcohol Consumption, Household Conflicts, Ouagadougou
Relational Health with Peers as a Buffer between Childhood Maltreatment and Trauma Symptoms among College Women: Brief Report

ABSTRACT Despite knowledge of long-term risks associated with child maltreatment among women, relatively less is known about protective factors that buffer against trauma sequelae in young adulthood. Our cross-sectional study investigated relational health with peers as a potential protective factor for women in the relation between child maltreatment (emotional abuse, physical abuse, emotional neglect, physical neglect) and young adult trauma symptoms. An ethnically diverse sample of college women (N = 257, M age = 19.74) completed self-report questionnaires related to childhood maltreatment, current trauma symptoms, and relational peer health. Relational health with peers buffered against the development of trauma symptoms from emotional and physical abuse but not from emotional or physical neglect. Findings demonstrate the importance of fostering healthy peer connections for young adult women exposed to child abuse. Clinical implications for developing interventions to facilitate relational health are discussed.
Drug-Induced Lysosomal Impairment Is Associated with the Release of Extracellular Vesicles Carrying Autophagy Markers

Amiodarone is a cationic amphiphilic drug used as an antiarrhythmic agent. It induces phospholipidosis, i.e., the accumulation of phospholipids within organelles of the endosomal–lysosomal system. Extracellular vesicles (EVs) are membrane-enclosed structures released by any type of cell and retrieved in every fluid of the body. EVs have been initially identified as a system to dispose cell waste, but they are also considered to be an additional manner to transmit intercellular signals. To understand the role of EVs in drug-induced phospholipidosis, we investigated EVs release in amiodarone-treated HEK-293 cells engineered to produce fluorescently labelled EVs. We observed that amiodarone induces the release of a higher number of EVs, mostly of a large/medium size. EVs released upon amiodarone treatment do not display significant morphological changes or altered size distribution, but they show a dose-dependent increase in autophagy associated markers, indicating a higher release of EVs with an autophagosome-like phenotype. Large/medium EVs also show a higher content of phospholipids. Drugs inducing lysosomal impairment such as chloroquine and bafilomycin A1 similarly prompt a higher release of EVs enriched in autophagy markers. This result suggests a mechanism associated with amiodarone-induced lysosomal impairment more than a connection with the accumulation of specific undigested substrates. Moreover, the implementation of the lysosomal function by overexpressing TFEB, a master gene regulator of lysosomal biogenesis, prevents the amiodarone-induced release of EVs, suggesting that this could be a feasible target to attenuate drug-induced abnormalities.
Preliminary evaluation of the materials in Egypt for Superpave implementation

The Egyptian code of practice for the design of asphalt mixtures is based on Marshall mix design methodology. There is a significant shift to Superpave mix design worldwide and Egypt is one of the countries that is expected to follow this shift. For the transition to be smooth and easy for practitioners, an analysis was done to evaluate the compliance of the gradation bands available in the current Egyptian code of practice to Superpave requirements. This showed that only a few of the gradation bands could still be used with Superpave mix design, and these only with some considerations. Four gradations were developed from two of the gradation bands, and these mixes were designed using both Superpave and Marshall mix design methods. The Superpave mix design samples were tested for stability and flow. A comparison was made between both designs. The results showed that Superpave mix design yielded lower optimum binder content and that its samples had higher values of stability and flow.
Palatable Flavoured Fluids without Carbohydrates and Electrolytes Do Not Enhance Voluntary Fluid Consumption in Male Collegiate Basketball Players in the Heat

Using palatable fluids to enhance drinking in athletes who display insufficient compensatory hydration behaviour may mitigate the risks of hypohydration and performance deficits. However, it is unclear whether flavour can independently enhance fluid consumption. This study examined the effects of a colourless, artificially sweetened flavoured water (FW), without carbohydrates and with negligible amounts of sodium, compared to plain water (W) on fluid consumption in male collegiate basketball players in a practical game setting. Eighteen male basketball players (age 23.1 ± 1.3 years) played a 3v3 basketball small-sided game. The players were randomly assigned to consume either FW or W. Pre-game urine-specific gravity, fluid consumption, body mass, and hedonic taste perceptions were assessed. Basketball performance was analysed through notational analysis. Ratings of perceived exertion and thirst were recorded at pre-, post-game, and at each rest period. Heart rate was recorded throughout the gameplay. Despite significantly higher hedonic ratings for FW than W (6.78 ± 0.83 vs. 5.56 ± 1.33, p = 0.033, d = 1.36), there were no significant differences in fluid consumption (1083 ± 32 mL vs. 1421 ± 403 mL, p = 0.068, d = 0.92). Our result highlighted that using palatable fluids as a strategy to increase fluid consumption during high-intensity gameplay in the heat may not be effective if used without carbohydrates and electrolytes. Practitioners could consider both fluid palatability and composition in establishing a hydration plan for athletes.
Destructive Role of COVID-19 Fear on Nurses Performance: Mediating Role of Stress

Given its importance to psychological issues, the COVID-19 pandemic has created numerous challenges for all individuals, but healthcare professionals and particularly nursing staff are at front lines, and their performance is significantly affected. The current study relates COVID-19 fear with psychological strain, i.e., stress amongst the nursing staff. Moreover, the intervening role of COVID-19 stress between COVID-19 fear and the performance of the nursing staff has also been tested. An online survey was conducted to collect data from nurses. A total of 471 responses of nurses were received during the process of online data collection from 16 November 2020 to 30 April 2021. Results revealed the significant effect of COVID-19 fear on COVID-19 stress and the performance of nurses. Additionally, the results substantiate that COVID-19 stress mediates between COVID-19 fear and the health care performance of nurses. COVID-19 fear has become a psychological consequence that increases stress among nursing staffs. This study fills the research gap about the performance of the health care sectors, particularly with respect to COVID-19 fear and COVID-19 stress among nurses. Hence, COVID-19 fear plays a significant role in COVID-19 stress in terms of influencing the health care performance of nurses. Overall, the results give pragmatic insights for the consequences of the COVID-19 pandemic.
Robust wave-feature adaptive heartbeat classification based on self-attention mechanism using a transformer model

Objective. Electrocardiography is a common method for screening cardiovascular diseases. Accurate heartbeat classification assists in diagnosis and has attracted great attention. In this paper, we proposed an automatic heartbeat classification method based on a transformer neural network using a self-attention mechanism. Approach. An adaptive heartbeat segmentation method was designed to selectively focus on the time-dependent representation of heartbeats. A one-dimensional convolution layer was used to embed wave characteristics into symbolic representations, and then, a transformer block using multi-head attention was applied to deal with the dependence of wave-embedding. The model was trained and evaluated using the MIT-BIH arrhythmia database (MIT-DB). To improve the model performance, the model pre-trained on MIT-BIH supraventricular arrhythmia database (MIT-SVDB) was used and fine-tuned on MIT-DB. Main results. The proposed method was verified using the MIT-DB for two groups. In the first group, our method attained F1 scores of 0.86 and 0.96 for the supraventricular ectopic beat class and ventricular ectopic beat class, respectively. In the second group, our method achieved an average F1 value of 99.83% and better results than other state-of-the-art methods. Significance. We proposed a novel heartbeat classification method based on a transformer model. This method provides a new solution for real-time electrocardiogram heartbeat classification, which can be applied to wearable devices
Risk Due to ABO Incompatibility and Donor-Recipient Weight Mismatch in Living Donor Kidney Transplantation: A National Cohort Study

The effect of donor-recipient weight mismatch is not well established in ABO-incompatible living donor kidney transplantation (LDKT). A total of 2584 LDKT patients in the Korean Organ Transplantation Registry were classified into four groups according to the presence or absence of ABO incompatibility and donor-recipient weight mismatch (donor-to-recipient weight ratio (DRWR) < 0.8). In a multivariable Cox analysis, the combination of ABO incompatibility and DRWR incompatibility (n = 124) was an independent risk factor for graft survival (HR = 2.73, 95% CI = 1.11–6.70) and patient survival (HR = 3.55, 95% CI = 1.39–9.04), whereas neither factor alone was a significant risk factor for either outcome. The combination of ABO incompatibility and DRWR incompatibility was not an independent risk factor for biopsy-proven graft rejection (HR = 1.27, 95% CI = 0.88–1.82); however, it was an independent risk factor for pneumonia (HR = 2.94, 95% CI = 1.64–5.57). The mortality rate due to infection was higher among patients with both ABO incompatibility and DRWR incompatibility than among patients with neither factor or with either factor alone. The combination of ABO incompatibility and DRWR incompatibility was an independent risk factor for graft and patient survival after LDKT, whereas neither factor alone significantly affected graft or patient survival. Thus, donor-recipient weight matching should be cautiously considered in LDKT with ABO incompatibility.