Miracle-dz/UniFAR-FTUs huggingface dataset:
Using Accelerometer Equipped GPS Devices in Place of Paper Travel Diaries to Reduce Respondent Burden in a National Travel Survey

Abstract Purpose — The Department for Transport's 2011 GPS National Travel Survey (NTS) pilot study investigated whether personal GPS devices and automated data processing could be used in place of the 7-day paper diary. Using GPS technology could reduce the relatively high burden that the diary places upon respondents, reduce costs and improve data quality. Design/methodology/approach — Data was collected from c.900 respondents. Practical changes were made to the existing methodology where necessary, including the collection of information to support data processing. Processing was undertaken using the University of Eindhoven's Trace Annotator. Results from the GPS pilot were then compared to those from the main NTS diaries for the same period. Findings — There were no insurmountable problems using GPS devices to collect data; however, the processed GPS data did not resemble the diary outputs, making GPS unsuitable for the NTS. The GPS data produced fewer and longer trips than the diary data. The purpose of a quarter of the GPS trips was unclear, and a disproportionate share started and ended at home. Research limitations — Further work to manually inspect trips identified via validation as unfeasible and subsequently refine the processing algorithms would have been desirable had time permitted. GPS data processing may have been hindered by missing GPS data, particularly in the case of rail travel. Originality/value — This research used an accelerometer-equipped GPS device to better predict the method of travel. It also combined addresses that respondents reported having visited during the travel week with GIS data to code the purpose of trips without using a post-processing prompted-recall survey.
GLIM criteria represent a more suitable tool to evaluate the nutritional status and predict postoperative motor functional recovery of older patients with hip fracture: A retrospective study

Early recognition of malnutrition is essential to improve the prognosis of older patients with hip fracture. The Nutritional Risk Screening 2002 (NRS-2002), the Short-Form Mini Nutritional Assessment (MNA-SF) and the Global Leadership Initiative on Malnutrition (GLIM) are widely used in malnutrition diagnosis. However, criteria for predicting postoperative hip joint motor function in older patients with hip fractures are still necessary. The objective of this study was to select the most appropriate criteria from the NRS-2002, the MNA-SF and the GLIM in predicting the postoperative hip joint motor function recovery 1 year after surgery. This retrospective observational study included 161 patients aged ≥ 65 years with hip fractures. The nutritional status of patients was determined by the NRS-2002, MNA-SF and GLIM. The Harris hip joint score (HHS), the primary outcome of this study, was used to evaluate hip joint motor function. HHS was classified as excellent (HHS > 75) or non-excellent outcomes (HHS ≤ 75). Logistic regression models for hip joint motor function recovery were constructed. Both the receiver operating characteristic curve and the decision curve analysis were used to select the most predictive criteria. The overall mean age of the 161 patients was 77.90 ± 8.17. As a result, NRS-2002 (OR:0.06, 95%CI [0.01, 0.17]), MNA-SF (OR:0.05, 95%CI [0.00, 0.23]) and GLIM (OR of moderate: 0.03, 95%CI [0.01, 0.11]; OR of severe: 0.02 [0.00, 0.07]) were predictive for recovery of hip joint motor function. Additionally, both the area under curve of the receiver operating characteristic curve (NRS-2002: 81.2 [73.8, 88.6], MNA-SF: 76.3 [68.5, 84.2], GLIM: 86.2 [79.6,92.8]) and the decision curve analysis showed the GLIM was better than others. Compared with NRS-2002 and MNA-SF, GLIM was a more suitable nutritional assessment criteria to predict the postoperative recovery of hip joint motor function for older patients with hip fracture 1 year after surgery.
Distribution and origin of ground ice in University Valley, McMurdo Dry Valleys, Antarctica

Abstract Ground ice is one of the most important and dynamic geologic components of permafrost; however, few studies have investigated the distribution and origin of ground ice in the McMurdo Dry Valleys of Antarctica. In this study, ice-bearing permafrost cores were collected from 18 sites in University Valley, a small hanging glacial valley in the Quartermain Mountains. Ground ice was found to be ubiquitous in the upper 2 m of permafrost soils, with excess ice contents reaching 93%, but ground ice conditions were not homogeneous. Ground ice content was variable within polygons and along the valley floor, decreasing in the centres of polygons and increasing in the shoulders of polygons towards the mouth of the valley. Ground ice also had different origins: vapour deposition, freezing of partially evaporated snow meltwater and buried glacier ice. The variability in the distribution and origin of ground ice can be attributed to ground surface temperature and moisture conditions, which separate the valley into distinct zones. Ground ice of vapour-deposition origin was predominantly situated in perennially cryotic zones, whereas ground ice formed by the freezing of evaporated snow meltwater was predominantly found in seasonally non-cryotic zones.
Reply to comment by Remya et al. on “Effects of electron temperature anisotropy on proton mirror instability evolution”

In the comment to our paper, Remya et al. (2017) state that we conclude that their theory is incorrect; however, no such conclusion is in our paper. In fact, as stated in their paper, we agree with their theory that shows the impact of heavy ions and electron temperature anisotropy on the competition of the ion anisotropy instabilities. While their linear theory is correct, our paper focused on the nonlinear evolution, where one needs to be careful in assuming a given electron anisotropy, because electrons themselves can be unstable to the electron whistler instability, which quickly lowers the anisotropy to levels where, in the absence of heavy ions, it is not sufficient to significantly change the balance between proton cyclotron and mirror mode. We agree that the electron whistler instability will not lead to complete isotropization of the electrons but only lower it to the instability threshold. In the parameter regime addressed, this limited isotropization will still eliminate the dominance of mirror mode and restore the usual dominance of the proton cyclotron mode, so our point still stands. Our simulations showed an isotropization of the electrons beyond the electron whistler threshold. In this reply, we will show that there are two contributing reasons: The nonlinear evolution of the mirror instability affects the electron anisotropy, as does unphysical numerical heating due to the limited resolution of a particle‐in‐cell simulation. We further discuss the coexistence of electron whistler instability and mirror instability, and we agree that both instabilities can be present in the magnetosheath.
A computational model predicts sex-specific responses to calcium channel blockers in mammalian mesenteric vascular smooth muscle

The function of the smooth muscle cells lining the walls of mammalian systemic arteries and arterioles is to regulate the diameter of the vessels to control blood flow and blood pressure. Here, we describe an in silico model, which we call the ‘Hernandez–Hernandez model’, of electrical and Ca2+ signaling in arterial myocytes based on new experimental data indicating sex-specific differences in male and female arterial myocytes from murine resistance arteries. The model suggests the fundamental ionic mechanisms underlying membrane potential and intracellular Ca2+ signaling during the development of myogenic tone in arterial blood vessels. Although experimental data suggest that KV1.5 channel currents have similar amplitudes, kinetics, and voltage dependencies in male and female myocytes, simulations suggest that the KV1.5 current is the dominant current regulating membrane potential in male myocytes. In female cells, which have larger KV2.1 channel expression and longer time constants for activation than male myocytes, predictions from simulated female myocytes suggest that KV2.1 plays a primary role in the control of membrane potential. Over the physiological range of membrane potentials, the gating of a small number of voltage-gated K+ channels and L-type Ca2+ channels are predicted to drive sex-specific differences in intracellular Ca2+ and excitability. We also show that in an idealized computational model of a vessel, female arterial smooth muscle exhibits heightened sensitivity to commonly used Ca2+ channel blockers compared to male. In summary, we present a new model framework to investigate the potential sex-specific impact of antihypertensive drugs.
SHRIMP U-Pb Geochronology of the Closepet Granite and Peninsular Gneiss, Karnataka, South India

Zircons separated from a sample of Peninsular gneiss (82-KD 14) from Kabbaldurga quarry, and a homogeneous Closepet granite (KO84-13) from near Ramnagaram have been dated with the ion microprobe SHRIMP. The Peninsular gneiss sample, a metatexite, contains an arrested charnockite transition and constitutes an amphibolite-granulite close pair. It was split into amphibolite facies, transitional and granulite facies (charnockite) domains prior to zircon separation. Zircon populations separated from each domain are morphologically similar and have the same U-Pb isotopic systematics suggesting that they record events common to both the amphibolite facies and granulite facies domains. The pooled data yield a U-Pb age of 2963 ± 4 Ma (20σ) for the gneiss protolith at Kabbaldurga, with a few older inherited zircons found as cores in magmatic zircon. A concordant U-Pb age of 2528 ± 5 Ma was obtained for newly grown zircon and overgrowths, interpreted to have formed during a migmatisation event which led to the formation of the Closepet granite. Zircons separated from the Closepet granite sample gave a concordant age of 2513 ± 5 Ma, interpreted as the time of crystallisation of the granite. This age was obtained from both zircon cores and overgrowths which are indistinguishable in age and arc both interpreted to have formed during the melting event. In preserved cores no indication of any inherited grains with a significantly older history was found. This is the first precise age on the Closepet granite. The slight age difference between the metatexite event (2528 ± 5 Ma) and the granite age 2513 ±5 Ma) may indicate the length of time of the event during which the Closepet granite formed. The data provide a minimum constraint on the age of the charnockite event in the region.
Primary and secondary care service use and costs associated with frailty in an ageing population: longitudinal analysis of an English primary care cohort of adults aged 50 and over, 2006–2017

Abstract Background Frailty becomes more prevalent and healthcare needs increase with age. Information on the impact of frailty on population level use of health services and associated costs is needed to plan for ageing populations. Aim To describe primary and secondary care service use and associated costs by electronic Frailty Index (eFI) category. Design and Setting Retrospective cohort using electronic health records. Participants aged ≥50 registered in primary care practices contributing to the Oxford Royal College of General Practitioners Research and Surveillance Centre, 2006–2017. Methods Primary and secondary care use (totals and means) were stratified by eFI category and age group. Standardised 2017 costs were used to calculate primary, secondary and overall costs. Generalised linear models explored associations between frailty, sociodemographic characteristics. Adjusted mean costs and cost ratios were produced. Results Individual mean annual use of primary and secondary care services increased with increasing frailty severity. Overall cohort care costs for were highest in mild frailty in all 12 years, followed by moderate and severe, although the proportion of the population with severe frailty can be expected to increase over time. After adjusting for sociodemographic factors, compared to the fit category, individual annual costs doubled in mild frailty, tripled in moderate and quadrupled in severe. Conclusions Increasing levels of frailty are associated with an additional burden of individual service use. However, individuals with mild and moderate frailty contribute to higher overall costs. Earlier intervention may have the most potential to reduce service use and costs at population level.
Investigating the Roles of the Visual and Parietal Cortex in Representing Content versus Context in Visual Working Memory

Content-to-context binding is crucial for working memory performance. Using a dual-serial retrocueing (DSR) task on oriented gratings, Yu et al. (2020) found that content (orientation) of both prioritized and unprioritized memory items (PMI; UMI) was represented simultaneously in visual cortex, while their context (location) was represented in intraparietal sulcus (IPS), with a priority-based remapping of the representation of content and context of the UMI in each region, respectively. This registered report acquired fMRI of 24 healthy adults while they performed a DSR task with location as the to-be-reported content and orientation as the task-relevant context. We contrasted three accounts: domain-dependent, the engagement of visual and parietal regions depends on the feature domain (orientation vs location); functional, the engagement of these regions depends on their function (content vs context); and hybrid—a combination of the domain-dependent account and the additional stipulation that IPS encodes context regardless of domain. Delay-period activity in early visual cortex conformed most closely with functional predictions: robust priority-sensitive representation of stimulus location (content), but no evidence for the active representation of stimulus orientation (context). Delay-period activity in IPS, in contrast, conformed most closely to predictions of the hybrid account: active representation of content (location) and of prioritized context (orientation). Exploratory analyses further supported the hybrid account of IPS, revealing univariate sensitivity to variation in both content and context load, the latter in a manner that predicted individual differences in behavior. The representation of visual information in working memory is highly dependent on behavioral context.
Longitudinal changes in anthropometric, physiological, and physical qualities of international womens rugby league players

This is the first study to assess longitudinal changes in anthropometric, physiological, and physical qualities of international womens rugby league players. Thirteen forwards and 11 backs were tested three times over a 10-month period. Assessments included: standing height and body mass, body composition measured by dual x-ray absorptiometry (DXA), a blood panel, resting metabolic rate (RMR) assessed by indirect calorimetry, aerobic capacity (i.e., VLO2max) evaluated by an incremental treadmill test, and isometric force production measured by a force plate. During the pre-season phase, lean mass increased significantly by [~]2% for backs (testing point 1: 47 kg; testing point 2: 48 kg) and forwards (testing point 1: 50 kg; testing point 2: 51 kg) (p = [≤] 0.05). Backs significantly increased their VLO2max by 22% from testing point 1 (40 ml{middle dot}kg-1{middle dot}min-1) to testing point 3 (49 ml{middle dot}kg-1{middle dot}min-1) (p = [≤] 0.04). The VLO2max of forwards increased by 10% from testing point 1 (41 ml{middle dot}kg-1{middle dot}min-1) to testing point 3 (45 ml{middle dot}kg-1{middle dot}min-1), however this change was not significant (p = [≥] 0.05). Body mass (values represent the range of means across the three testing points) (backs: 68 kg; forwards: 77-78 kg), fat mass percentage (backs: 25-26%; forwards: 30-31%), resting metabolic rate (backs: 7 MJ{middle dot}day-1; forwards: 7 MJ{middle dot}day-1), isometric mid-thigh pull (backs: 2106-2180 N; forwards: 2155-2241 N), isometric bench press (backs: 799-822 N; forwards: 999-1024 N), isometric prone row (backs: 625-628 N; forwards: 667-678 N) and bloods (backs: ferritin 21-29 ug/L, haemoglobin 137-140 g/L, iron 17-21 umol/L, transferrin 3 g/L, transferring saturation 23-28%; forwards: ferritin 31-33 ug/L, haemoglobin 141-145 g/L, iron 20-23 umol/L, transferrin 3 g/L, transferrin saturation 26-31%) did not change (p = [≥] 0.05). This study provides novel longitudinal data which can be used to better prepare women rugby league players for the unique demands of their sport, underpinning female athlete health.
Self-regulation of the DNA N6-adenine methyltransferase AMT1 in the unicellular eukaryote Tetrahymena thermophila

DNA N6-adenine methylation (6mA) is involved in gene transcription as a potential epigenetic mark in eukaryotes. Despite the reported methyltransferase (MTase) for 6mA methylation in several eukaryotes, the regulatory mechanisms that govern the activity of 6mA MTase remain elusive. Here, we exploited the 6mA MTase AMT1 to elucidate its self-regulation in the unicellular eukaryote Tetrahymena thermophila. Firstly, detailed endogenous localization of AMT1 was delineated both in vegetative and sexual stages, revealing a correlation between the 6mA reestablishment in the new MAC and the occurrence of zygotically expressed AMT1. Catalytically inactive AMT1 reduced 6mA level on the AMT1 gene and its expression level, suggesting that AMT1 modulated its own transcription via 6mA. Furthermore, AMT1-dependent 6mA regulated the transcription of its target genes thus affecting the cell fitness, as demonstrated by manipulating the dosage of AMT1 using AMT1-RNAi strains. Our findings unveil a positive feedback loop of transcriptional activation on the AMT1 gene and highlight the crucial role of AMT1-dependent 6mA for gene transcription.
Channel models for ultrawideband personal area networks

This article describes the modeling of ultrawideband wireless propagation channels, especially for the simulation of personal area networks. The IEEE 802.15. 3a standards task group has established a standard channel model to be used for the evaluation of PAN physical layer proposals. We discuss the standard model, the measurements that form its basis, and the possibilities for future improvements. This article points out the important differences between UWB channels and narrowband wireless channels, especially with respect to fading statistics and time of arrival of multipath components. The impacts on the different propagation conditions on system design, like RAKE receiver performance, are elaborated.
Starting and Sustaining Digital Humanities/Digital Scholarships Centers: Lessons from the Trenches

Along with the growth in Digital Humanities (DH) and Digital Scholarship (DS) as digital methods, resources, and tools for research, teaching and dissemination, interest in starting DH/DS centers as a means to support and sustain researchers and projects is fast increasing. For those leading these initiatives, it raises questions about the ways to engage possible stakeholders to develop support for a centre, apply existing models, secure funding sources, and many others. This article contributes to this discussion by examining the experiences of ten DH/DS centers in North America and discerning smart practices for those wishing to start a similar center. Often started by faculty or administrative champions, the interviewed centers have a long history of operations. They offer a suite of activities and services, ranging from consulting, training, access to technology, project support, and others, with staff drawn from libraries, faculties, student ranks, and other locations. These efforts support teachers, researchers, and students in their efforts to undertake DH/DS projects. The centers are often funded through a combination of base budgets and soft money and may be based in a library or faculty. The paper concludes with implications for practice for those wishing to start their own DH/DS center.
Categorial Relations in (Re)constructing Topoi and in (Re)modeling Topology as a Methodology: Vertical, horizontal, heuristic and epistemological interdependencies

The article reflects on the process of category development and category application that was relevant for the analysis of topoi in a specific corpus of travelogues. In this process, the investigation of the corpus and the (re)modeling of topology as a methodology were closely intertwined. This includes the interconnected modeling of the category topos and the (re)construction of concrete topos concepts. The paper proposes a methodological framework that represents categorial relations understood as relations between different types of categories, different concepts as instantiations of the same category as well as relations between categories and different heuristic levels. In addition to the definition and spatial representation of these relations, the iterative dimension of research processes in the digital humanities is discussed with regard to categorial interdependencies. Against the background of this (meta)model and the discussion of concrete examples from the study of travelogues, perspectives on possible follow-up differentiations and conceivable future work are touched upon.
Using satellite-based soil moisture to detect and monitor spatiotemporal traces of agricultural drought over Bundelkhand region of India

Detection and monitoring of seasonal agricultural drought at sub-regional scale is a complex theme due to inefficient spatiotemporal indicators. This study presents a new time-based function of spaceborne soil moisture as an efficient indicator. Bundelkhand of Central India, a frequently agricultural drought affected region, was used as the study area. Rabi agricultural season (October–May) being the dominant agricultural return period, was chosen as the study period. Coarse resolution soil moisture (SMc) obtained from European space agency under climate change initiative program was spatially downscaled (SMd) to meet spatial scale at sub-regional level with overall root-mean-square error under 0.065 cm3/cm3. Indirect validation of SMd was done using temporal impact of rainfall/dry spell on SMd and spatiotemporal impact of SMd on vegetation condition. SMd was found to agree with phenomenon as expected in natural processes and hence it was assumed to be validated. The time-based function derived from spatiotemporal SMd (FSMs) was found to be better related with fluctuations in seasonal crop yield (Ys) at district level as compared to a similar function (FVCIs) derived using vegetation condition index (VCI) from Moderate Resolution Imaging Spectroradiometer. FSMs outperformed FVCIs having better correlation coefficient (R ≥0.8) and Nash–Sutcliffe efficiency coefficient (NSE) than FVCIs for most of the districts. Unlike FVCIs, it also efficiently detected the lowest and highest Ys for majority of the districts representing better association with agricultural drought. Subsequently, frequent soil moisture deficit areas were mapped by using FSMs to visualize the spatiotemporal severity of agricultural drought in the region during Rabi season.
An Extension Of The Drift-flux Model For Submarine Granular Flows

To model submarine flows of granular materials we propose an extension of the drift-flux approach. The extended model is able to represent dilute suspensions as well as dense granular flows. The dense granwular flow is modelled as a Herschel–Bulkley fluid, with a yield stress that depends on the dispersed phase pressure. Qualitative numerical experiments show that the model is able to correctly reproduce the stability of submerged sand heaps with different internal angles of friction and initial slopes. When initially starting with heaps with an angle smaller than the internal angle of friction, the heaps are stable. When starting with heaps with angles larger than the internal angle of friction, a flow of solid material is initiated. The flow later stops when the bed is at an angle smaller than the internal angle of friction.