Miracle-dz/UniFAR-FTUs huggingface dataset:
Management of Marginal Zone Lymphoma: A Canadian Perspective

Marginal zone lymphomas (MZL) are a rare, heterogenous group of lymphomas, accounting for 5–17% of indolent non-Hodgkin lymphomas in the western world. They can be further divided into three subtypes: extranodal MZL, splenic MZL, and nodal MZL. These subtypes differ in clinical presentation and behavior, which influences how they are managed. There is currently no standard of care for the treatment of MZL, owing to the difficulty in conducting phase 3 randomized trials in MZL, and the fact that there are limited data on the efficacy of therapy in individual subtypes. Treatment practices are thus largely borrowed from other indolent lymphomas and are based on patient and disease characteristics, as well as access to therapy. This review summarizes the Canadian treatment landscape for MZL and how these therapies may be sequenced in practice.
Effects of jet/vortex interaction on contrail formation in supersaturated conditions

The effects of the interaction between a model of aircraft trailing vortex and engine jets on the formation of a contrail in supersaturated ambient air are studied using Eulerian-Lagrangian two-phase flows large-eddy simulations. The three-dimensional structure of the contrail, the mean flow properties, and the statistical correlations between ice and water vapor are analyzed for different jet and vortex parameters and different soot particle numbers. The interaction is characterized by the entrainment of the jets by the trailing vortex. In the four-engines case, particles exhausting the outboard jets are exposed to local higher supersaturation due to the temperature drop in the low-pressure vortex core region. The soot particle number affects both the structure and the global characteristics of the contrail. The increase in soot loading results in stronger vapor depletion – which leads to larger ice production – and to smaller ice particles for a given amount of vapor exhaust. The fraction of activated particles decreases with soot loading because of the increased competition for the vapor available for condensation. Of particular interest is the interaction between the jet/vortex turbulence and ice microphysics (activation, condensation, particle size distribution, and optical depth). It is found that the characteristic timescales of mixing and condensation can be of the same order in the jet regime. For the present high ambient supersaturation conditions, the competition between the entrainment of humid ambient air and vapor depletion plays an important role in determining the initial growth of the contrail and the spatial and size distributions of ice particles.
Etch‐tuned ridged waveguide magneto‐optic isolator

Isolation ratios as large as 3000 to 1 (−35 dB) at wavelengths near 1.55 μm have been measured on ridged waveguide Faraday rotation isolators. These are the best results ever reported for any waveguide isolator. Single‐mode, triple‐layer bismuth yttrium iron garnet films were chemically etched to reduce the linear birefringence of the active top layer to zero at 1.49 μm. Ion implantation enhanced etching was used to create ridges 8 μm wide and 0.5 μm high. Using fiber coupled light from a tunable color center laser, isolation ratios of −25 dB or better were achieved over a wavelength range of ±0.03 μm near 1.5 μm. A silica overlayer was used to increase the effective thickness of the active layer and raise the optimum wavelength from 1.49 to 1.55 μm.
Shape-space smoothing splines for planar landmark data

A method is developed for fitting smooth curves through a series of shapes of landmarks in two dimensions using unrolling and unwrapping procedures in Riemannian manifolds. An explicit method of calculation is given which is analogous to that of Jupp & Kent (1987) for spherical data. The resulting splines are called shape-space smoothing splines. The method resembles that of fitting smoothing splines in real spaces in that, if the smoothing parameter is zero, the resulting curve interpolates the data points, and if it is infinitely large the curve is a geodesic line. The fitted path to the data is defined such that its unrolled version at the tangent space of the starting point is a cubic spline fitted to the unwrapped data with respect to that path. Computation of the fitted path consists of an iterative procedure which converges quickly, and the resulting path is given in a discretised form in terms of a piecewise geodesic path. The procedure is applied to the analysis of some human movement data, and a test for the appropriateness of a mean geodesic curve is given. Copyright 2007, Oxford University Press.
The Joint Associations of Physical Activity and Sedentary Behaviors on Adiposity during Adolescence: The 1993 Pelotas (Brazil) Cohort Study

A prior study conducted in high-income countries demonstrated that specific sedentary behavior, such as TV viewing, is prospectively associated with adiposity in both active and inactive adolescents. The aim of this study was to examine the joint associations of sedentary behaviors and moderate- and vigorous-intensity physical activity (MVPA) with adiposity among Brazilian adolescents. This prospective cohort study included 377 participants of the 1993 Pelotas (Brazil) Study who completed an accelerometry assessment at age 13 years and a dual-energy X-ray absorptiometry (DXA) assessment at age 18 years. Accelerometer-measured MVPA was dichotomized into high (≥60 min/day) and low (<60 min/day). Accelerometer-measured sedentary time (SED) was dichotomized into low (<49 min/h) and high (≥49 min/h) based on the median. Self-reported TV viewing time was also dichotomized into low (<3 h/day) and high (≥3 h/day) based on the median. We combined the two MVPA groups (high and low) and two SED groups (low and high) to form the four MVPA&SED groups: high&low, high&high, low&low, and low&high. We also created four MVPA&TV groups in the same manner. Fat mass index (FMI; kg/m2) was calculated using DXA-derived fat mass. Multivariable linear regression analyses compared FMI at 18 years among the four MVPA&SED groups and among the four MVPA&TV groups, adjusting for socioeconomic status, energy intake, and baseline adiposity. The analysis results showed that SED or TV viewing time was not prospectively associated with adiposity in both active and inactive Brazilian adolescents. This study suggests that the association between specific sedentary behaviors, such as TV viewing, and adiposity may differ across societal settings—in this case, high-income vs. middle-income countries.
In vivo quantification of human dermal skin aging using SHG and autofluorescence

There are visible changes during skin aging. In the extracellular matrix these changes referred to as intrinsic aging (skin areas not exposed to sunlight) and extrinsic aging can be measured using various methods, such as subjective clinical evaluation, histology and molecular analysis. In this study we developed a new parameter for the non-invasive quantitative determination of dermal skin aging utilizing a five-dimensional intravital tomography (5D-IVT). This device, also known as 5D - multi-photon laser scanning microscopy, is a powerful tool to investigate (photo)aging-associated alterations in vivo. Structural alterations in the dermis of extrinsically aged (chronically sun-exposed) and intrinsically aged (sun-protected) human skin were recorded utilizing the collagen-specific second harmonic generation (SHG) signal and the elastin-specific autofluorescence (AF) signal. Recording took place in young and elderly volunteers. The resulting images were processed in order to gain the elastin percentage and the collagen percentage per image. Then, the elastin - to - collagen ratio (ELCOR) was calculated. With respect to volar forearm skin, the ELCOR significantly increased with age. In elderly volunteers, the ELCOR value calculated for the chronically sun-exposed temple area was significantly augmented compared with the sun-protected upper arm area. Based on 5D-IVT we introduce the ELCOR as a new means to quantify age-associated alterations in the extracellular matrix of in vivo human skin. This novel parameter is compared to the currently used "SHG to AF aging index" of the dermis (SAAID).
Relativistic many-body calculations of energies of n = 3 states of Be-like ions

Energies of the 2s3s (), 2s3p (), 2s3d (), 2p3s (), 2p3p () and 2p3d () states for Be-like ions with nuclear charges Z in the range 4 - 30 and for Z = 54 are determined to second order in relativistic many-body perturbation theory starting from a frozen-core Dirac - Fock basis. Second-order Coulomb and second-order Breit - Coulomb correlation energies are evaluated. Corrections for the frequency dependence of the Breit interaction are taken into account in lowest order. Lamb-shift corrections to the energies are also included in lowest order. Comparisons are made with other theoretical calculations and with experimental data. We obtain an excellent agreement with experiment for term splitting, even for low-Z ions. Results for the 2p - 3d excitation energies for are also in very good agreement with experiment.
XIV. The distribution of electrons round impurities in monovalent metals

Summary A theoretical investigation is made of the distribution of electrons round a positively charged impurity dissolved in a monovalent metal. Applications are made to dissolved hydrogen, where the impurity is a proton, and to atoms such as zinc, gallium, etc., which are usually considered to contribute their electrons to the conduction electrons. In all cases the positive charge must be screened; and in many cases this is shown to occur through the formation of bound states below the level of the Fermi distribution. The relation of these results to the Hume-Rothery rule is discussed. The ideas introduced are used to calculate the heats of solution of hydrogen and of polyvalent metals in the noble metals, and to discuss the magnetic properties of these alloys. A detailed discussion is given of x-ray emission and absorption, the vacancy left in the x-ray shell being here treated as the positive impurity. In certain cases quantitative predictions are made about the energies of x-ray absorption edges. Dis.
Strategies to Prevent Early and Late-Onset Group B Streptococcal Infection via Interventions in Pregnancy

Group B Streptococcus is a Gram-positive bacterium that typically colonizes 10–30% of pregnant women, causing chorioamnionitis, preterm birth, and stillbirth, as well as neonatal sepsis and meningitis with early-onset disease (EOD) or late-onset disease (LOD) due to ascending infection or transmission during delivery. While there are some differences between EOD and LOD in terms of route of transmission, risk factors, and serotypes, the only preventive approach currently is maternal intrapartum antibiotic prophylaxis (IAP) which will not be able to fully address the burden of the disease since this has no impact on LOD. Probiotics and immunization in pregnancy may be more effective than IAP for both EOD and LOD. There is mixed evidence of probiotic effects on the prevention of GBS colonization, and the data from completed and ongoing clinical trials investigating different GBS vaccines are promising. Current vaccine candidates target bacterial proteins or the polysaccharide capsule and include trivalent, tetravalent, and hexavalent protein–polysaccharide conjugate vaccines. Some challenges in developing novel GBS vaccines include the lack of a correlate of protection, the potential for serotype switching, a need to understand interactions with other vaccines, and optimal timing of administration in pregnancy to maximize protection for both term and preterm infants.
Pointwise Confidence Intervals in Nonparametric Regression with Heteroscedastic Error Structure

We assume a nonparametric model with heteroscedastic error structure and consider pointwise confidence intervals for the mean. We construct them by using quantiles from a CornishhFisher expansion and from the wild bootstrap distribution, with as well as without a subsequent bias correction. It turns out that pure undersmoothing, where the full smoothness is used by the initial estimator, outperforms the method with a subsequent bias correction.
Growth Performance and Some Serum, Bone and Fecal Parameters of Broilers Fed with Different Levels of Calcium and Phosphorus

Aim of the study was to evaluate the effects of diet non-phytate phosphorus (P) and calcium (Ca) level on growth performance and some blood, bone and faeces parameters of broilers. A total of 480 one-day-old Ross 308 broilers were randomly allocated to 3 dietary treatments with 5 replicates for a 42-d study. Corn-soybean meal based diets were consisted of three different Ca and P concentrations for starter and grower periods. High, medium and low Ca and P levels in starter and grower periods were 1.05-0.49, 0.95-0.44, 0.85-0.41% and 0.87-0.42, 0.78-0.38, 0.69-0.34%, respectively. After the first 21-d feeding period, no differences were observed for feed intake (FI) but body weight (BW) and feed conversion ratio (FCR) were higher (P0.05). Fecal ash, tibia and sternum weight and sternum ash weren’t affected from the Ca and P concentrations but tibia ash were lower (P
Framework for Generation and Removal of Multiple Types of Adverse Weather from Driving Scene Images

Weather variation in the distribution of image data can cause a decline in the performance of existing visual algorithms during evaluation. Adding additional samples of target domain to training data or using pre-trained image restoration methods such as de-hazing, de-raining, and de-snowing, to improve the quality of input images are two promising solutions. In this work, we propose Multiple Weather Translation GAN (MWTG), a CycleGAN-based, dual-purpose framework that simultaneously learns weather generation and its removal from image data. MWTG consists of four GANs constrained using cycle consistency that carry out domain translation tasks between hazy, rainy, snowy, and clear weather, using an asymmetric approach. To increase network capacity, we employ a spatial feature transform (SFT) layer to fuse the features extracted from the weather layer, which contains high-level domain information from the previous generators. Further, we collect an unpaired, real-world driving dataset recorded under various weather conditions called Realistic Driving Scenes under Bad Weather (RDSBW). We qualitatively and quantitatively evaluate MWTG using the RDSBW and the variation of Cityscapes that synthesize weather effects, eg. , FoggyCityscape. Our experimental results suggest that MWTG can generate realistic weather in clear images and also accurately remove noise from weather images. Furthermore, the SOTA pedestrian detector ASCP is shown to achieve an impressive gain in detection precision after image restoration using the proposed MWTG method.
Resistance Switching Induced in BiMnO3 Ceramics

In our study BiMnO3 ceramics has been sintered. The X-ray diffraction test has shown that the crystal lattice symmetry is monoclinic and centrosymmetric. Grain structure and stoichiometry has been determined by scanning electron microscopy whereas local disorder by X-ray photoemission spectroscopy. Leakage currents dominated the D–E hysteresis loop. Electric conductivity has been measured in the 85–770 K range. The studied fresh ceramics shows semiconductor properties. Charge-order transition occurrence has been deduced. The dc resistance switching occurs following the application of electroformation at a high temperature range. This effect is reversible, i.e. the Rdc(T) recovers semiconductor properties after thermal and electric field treatment.
Health Benefits of Coffee Consumption for Cancer and Other Diseases and Mechanisms of Action

Coffee is one of the most widely consumed beverages worldwide, and epidemiology studies associate higher coffee consumption with decreased rates of mortality and decreased rates of neurological and metabolic diseases, including Parkinson’s disease and type 2 diabetes. In addition, there is also evidence that higher coffee consumption is associated with lower rates of colon and rectal cancer, as well as breast, endometrial, and other cancers, although for some of these cancers, the results are conflicting. These studies reflect the chemopreventive effects of coffee; there is also evidence that coffee consumption may be therapeutic for some forms of breast and colon cancer, and this needs to be further investigated. The mechanisms associated with the chemopreventive or chemotherapeutic effects of over 1000 individual compounds in roasted coffee are complex and may vary with different diseases. Some of these mechanisms may be related to nuclear factor erythroid 2 (Nrf2)-regulated pathways that target oxidative stress or pathways that induce reactive oxygen species to kill diseased cells (primarily therapeutic). There is evidence for the involvement of receptors which include the aryl hydrocarbon receptor (AhR) and orphan nuclear receptor 4A1 (NR4A1), as well as contributions from epigenetic pathways and the gut microbiome. Further elucidation of the mechanisms will facilitate the potential future clinical applications of coffee extracts for treating cancer and other inflammatory diseases.
Age-Friendly Community Interventions for Health and Social Outcomes: A Scoping Review

To address the numerous challenges associated with aging, increased attention has been given to the development of age-friendly cities and communities (AFCC) to promote healthy aging and social participation. However, limited evidence exists for addressing both health and social needs through the AFCC framework. We address this gap by conducting a scoping review of the interventions that target both health and social outcomes within the purview of the AFCC framework. The results showed that many of the successful interventions used a partnership model and behavioral change theories to inform the program design and implementation. The results also indicated that social participation and engagement played a key role in making the interventions successful. However, the results revealed that the literature is dominated by person-focused approaches. Future research should focus more on evaluating environmental-focused interventions and develop a holistic framework that combines both person- and environment-based approaches to healthy aging.
Sobrecarga e qualidade de vida dos cuidadores de pessoas acamadas em domicílio

Objective: To associate the sociodemographic profile with the work overload and the quality of life of caregivers of bedridden people. Methods: Cross-sectional study, carried out in 2019, with a total of 240 caregivers who answered three instruments: sociodemographic questionnaire, Zarit Burden Interview and the WHOQOL-bref. For analysis, the Chi-square, Fisher and Binary Logistic Regression tests were used. Results: Most caregivers (86.6%) were found to have moderate or severe overload and the overall quality of life score was 48.9 points. Caregivers that worked at home (OR=52.89), with health affected because of their involvement as a caregiver (OR=22.92) and who have lost control of their lives since the bedridden person’s illness (OR=49.38), were more likely to have poor quality of life. Conclusion: Occupation and period of care were significantly related to the quality of life of caregivers of bedridden people. The occupation “household” and overload factors are significant predictors of poor quality of life.
Validation of Fitness Switching Costs Scale (FSCS): Examining the Factor Structure and Measurement Precision

ABSTRACT The purpose of the study is to validate the 54-item Fitness Switching Costs Scale (FSCS). The FSCS consists of a third-order formative construct with four second-order formative constructs and 11 first-order reflective constructs. Although there was support for the reliability and validity of higher-order constructs, validity of the 11 first-order subscales has not been systematically investigated. Study 1 (n = 441) evaluates the factor structure of the first-order subscales using exploratory factor analysis and ensures the factorial validity of the subscales. Study 2 (n = 415) examines the measurement precision of the 11 first-order subscales using item response theory and shows high levels of measurement precision, while identifying some areas for improvement at the item level. Overall, the findings suggest that health and fitness researchers and practitioners can use the FSCS as a diagnostic tool to identify areas for a potential investment.
Ultra wide band electromagnetic scattering of a fractal profile

The relationship between the fractal dimension of a perfectly conducting bidimensionnal profile and the fractal dimension of the time domain scattered field is investigated. The first part of the paper is dedicated to the profile itself; implementation of the counting box method for fractal dimension estimation is described and improved by the adjunction of an iterative process involving a correlation criterion. The second part is about the field scattered by a fractal profile which is calculated by the method of moments; polarizations, directions of incidence and observation effects are studied. Influence of spectral window and of noise is also investigated. Results show that fractal dimensions of the field and of the profile are linked by a monotonous increasing function which weakly depends on the polarizations and on the directions of incidence and observation. Moreover, the fractal dimension shows robustness to noise.
Collection, evaluation and phenotypic diversity assessment of maize (Zea mays) germplasm from North Eastern Himalayan region

Primitive landraces and traditional cultivars of maize (Zea mays L.) are invaluable resources for the humankind. These need to be collected, evaluated, conserved and utilized for increasing agricultural production and quality enhancement. Based on extensive survey, 75 diverse maize accessions were collected from Nagaland and Manipur states of the North Eastern Himalayan region. These collections were evaluated under two different agro-ecological regions, New Delhi and Shillong during kharif 2012 and 2013 using 12 quantitative variables. There was significant morphological variability among the accessions. Trait specific cultivars were identified based on exploration related knowledge and phenotypic valuation. The cluster analysis was performed to assess the variation among genotypes and grouped them into five clusters based on phenotypic traits. The principal component analysis (PCA) was subjected to quantitative datasets to group the accessions and to study contribution of traits for phenotypic variation. The first two principal components explained more than 50% of the phenotypic variation. Plant height, ear height, grain yield, ear width, number of kernel rows and number of kernels per row were major contributing traits towards phenotypic diversity. The different groups obtained can be useful for deriving the inbred lines with diverse features and diversifying the heterotic pools.
Magnetization reversal induced by in-plane current in Ta/CoFeB/MgO structures with perpendicular magnetic easy axis

We investigate in-plane current-induced magnetization reversal under an in-plane magnetic field in Hall bar shaped devices composed of Ta/CoFeB/MgO structures with perpendicular magnetic easy axis. The observed relationship between the directions of current and magnetization switching and Ta thickness dependence of magnetization switching current are accordance with those for magnetization reversal by spin transfer torque originated from the spin Hall effect in the Ta layer.