Miracle-dz/UniFAR-FTUs huggingface dataset:
Developing a collaboration system for pancreatic cancer research: a clinical design science study

ABSTRACT Great potential exists for the use of information systems (IS) in medical research, as they already form the backbone of several long-term medical research projects. IS can potentially support practitioner-researchers (practitioners who conduct research in their areas of practice) by enabling collaboration, particularly when the number of cases is low and the treatment strategy is centralised. However, practitioner-researchers and academic researchers differ in their research approaches. In this clinical IS research effort, we designed an IS, together with a local hospital, for supporting research on pancreatic cancer by applying a design science research (DSR) approach. We also observed how DSR is accepted and used by practitioner-researchers in this context. Consequently, we not only developed an IS but also gained insights into the benefits of DSR in projects with heterogeneous participants, namely those from various fields with different experiences and requirements. The results show that DSR contributes to mutual understanding, transparency in the design process and long-term benefits for all parties involved, which was further confirmed by post-hoc interviews.
Pesquisa Nascer no Brasil: perfil da mortalidade neonatal e avaliação da assistência à gestante e ao recém-nascido

Estudo de coorte sobre a mortalidade neonatal na pesquisa Nascer no Brasil, com entrevista e avaliacao de prontuarios de 23.940 puerperas entre fevereiro de 2011 e outubro de 2012. Utilizou-se modelagem hierarquizada para analise dos potenciais fatores de risco para o obito neonatal. A taxa de mortalidade foi 11,1 por mil; maior nas regioes Norte e Nordeste e nas classes sociais mais baixas. O baixo peso ao nascer, o risco gestacional e condicoes do recem-nascido foram os principais fatores associados ao obito neonatal. A inadequacao do pre-natal e da atencao ao parto indicaram qualidade nao satisfatoria da assistencia. A peregrinacao de gestantes para o parto e o nascimento de criancas com peso < 1.500g em hospital sem UTI neonatal demonstraram lacunas na organizacao da rede de saude. Obitos de recem-nascidos a termo por asfixia intraparto e por prematuridade tardia expressam a evitabilidade dos obitos. A qualificacao da atencao, em especial da assistencia hospitalar ao parto se configura como foco prioritario para maiores avancos nas politicas publicas de reducao das taxas e das desigualdades na mortalidade infantil no Brasil.
Role of Brachytherapy Boost in Clinically Localized Intermediate and High-Risk Prostate Cancer: Lack of Benefit in Patients with Very High-Risk Factors T3b–4 and/or Gleason 9–10

Simple Summary In general, brachytherapy (BT) improves biochemical control in intermediate-to high-risk prostate cancer. We previously reported that importance of very high-risk factors (VHR: T3b–4 or Gleason score 9–10) and patients with double VHR (VHR-2) showed the worst prognosis among high-risk groups. We explored the role of BT-boost in patients with VHR and compared it to intermediate- and other high-risk groups. We confirmed that BT-boost improved prostate-specific antigen (PSA) control but resulted in equivalent overall survival rates for the intermediate- and high-risk groups, except for the patients with VHR. In the VHR-1 group (single VHR), BT-boost showed superior PSA control to conventional-dose RT (EQD2 ≤ 72 Gy) but not to the dose-escalated radiotherapy group (EQD2 ≥ 74 Gy). In the VHR-2 group, BT-boost did not improve the biochemical control rate of either Conv RT or DeRT. BT-boost showed no benefit over modern DeRT in the patients with VHR. Abstract This study examined the role of brachytherapy boost (BT-boost) and external beam radiotherapy (EBRT) in intermediate- to high-risk prostate cancer, especially in patients with very high-risk factors (VHR: T3b–4 or Gleason score 9–10) as patients with double very high-risk factors (VHR-2: T3b–4 and Gleason score 9–10) previously showed worst prognosis in localized prostate cancer. We retrospectively reviewed multi-institutional data of 1961 patients that were administered radiotherapy (1091 BT-boost and 872 EBRT: 593 conventional-dose RT (Conv RT: equivalent to doses of 2 Gy per fraction = EQD2 ≤ 72 Gy) and 216 dose-escalating RT (DeRT = EQD2 ≥ 74 Gy). We found that BT-boost improved PSA control and provided an equivalent overall survival rate in the intermediate- and high-risk groups, except for patients within the VHR factor group. In the VHR-1 group (single VHR), BT-boost showed a superior biochemical control rate to the Conv RT group but not to the DeRT group. In the VHR-2 group, BT-boost did not improve outcomes of either Conv RT or DeRT groups. In conclusion, BT-boost showed no benefit to modern DeRT in the patients with VHR; therefore, they are not good candidates for BT-boost to improve outcome and may be amenable to clinical trials using multimodal intensified systemic treatments.
Distribution of Pathogenicity Island Markers and Virulence Factors Genes of Extraintestinal Pathogenic Escherichia coli Isolates

Background: Extraintestinal pathogenic Escherichia coli (ExPEC) can colonize the urinary system with various virulence factors. Escaping from the host defense, can lead to serious infections, such as bacteremia and sepsis. Objectives: This study aimed to investigate the presence of phylogenetic groups, various virulence factor genes, and pathogenicity island (PAI) markers of extraintestinal and commensal E. coli isolates. Methods: Within January 2016 and December 2017, 50 E. coli isolates were isolated from simultaneous blood and urine samples of 25 patients hospitalized in Mersin University Faculty of Medicine, Turkey, and 50 commensal E. coli isolates were isolated from fecal 18 samples of healthy volunteers as the control group was included in the study. Phylogenetic groups, virulence factors genes, and PAI markers were determined by the multiplex polymerase chain reaction method. Results: The majority of ExPEC isolates were observed to be in phylogenetic group B2. All of the commensal E. coli isolates were detected in phylogenetic group A. The most predominant virulence factor gene was traT (80%). The most prevalent PAI marker was PAI IV536 (86%). However, the PAI I536, IJ96, and IIJ96 markers were not detected in any isolates. Only PAI IV536 was detected in commensal E. coli isolates. Conclusions: It was determined that E. coli isolates that cause uropathogenic and bloodstream infections contain a higher frequency of PAI than commensal isolates.
On a conjecture about the -permanent

Let A=(a ij ) be an n-by-n matrix. For any real μ, define the polynomial where l (σ) is the number of inversions of the permutation σ in the symmetric group Sn . We prove that P μ (A) is a strictly increasing function of μ ∈ [−1,1], for a Hermitian positive definite nondiagonal matrix A, whose graph is a tree.
Methods for shrinkage measurement considering stress development of curing structural adhesives

Joint strength and methods for their determination play a crucial role for component design within the development phase of adhesively bonded components. Shrinkage-induced stresses due to adhesive’s curing may reduce the maximum strength of the bonded components; conversely, ignoring their effects may overestimate the design value thereof. Accordingly, the accurate prediction of residual stresses is of high importance, and so is determination of relevant material parameters. Adhesive properties, such as Young’s modulus and shrinkage, change significantly throughout curing. These have to be determined according to various material models, which are tributary to the experimental determination of corresponding material parameters. In this paper, the effects of shrinkage and residual stresses on simple joint geometries are transiently determined using the extended rheometer (ExRheo). The ExRheo proved to be a reliable method to determine volume shrinkage through successful validation by mercury dilatometry. Furthermore, shrinkage of constrained specimens can be measured using ExRheo and showed to be lower compared to specimens that could shrink freely. Material-specific properties like onset of vitrification could also be detected with the presented method. Based upon these experimental results of thermo-analytical characterisation of structural adhesives during curing, data for finite element analysis (FEA) is gathered. Aforementioned results will lead to improvements of stress prediction for industrial applications.
Teachers Readiness towards Reproductive and Social Health Education

Sexual education has become a big issue in Malaysia over time since the country faces the highest number of sexually active teenagers. This sensitive issue causes the teaching process to become incomplete, lack of depth and insufficient. Teachers' readiness is essential in acknowledging curriculum reform, such as the Reproductive and Social Health Education (PEERS) curriculum. In general, the purpose of this study is to determine the level and correlation between Health Education (HE) teacher readiness in teaching PEERS curriculum in terms of content knowledge, pedagogical knowledge, and teacher attitudes. A quantitative approach with a survey method was used in this study. The selection sample was conducted by proportionate stratified random sampling involving a total of 354 HE teachers in Selangor secondary schools. The readiness of teachers in teaching the PEERS curriculum showed that the level of attitude is the highest value with a mean score of 4.05 followed by the level of content knowledge with a mean score of 4.00 and the last is the level of pedagogical knowledge with a mean score of 3.96. In addition, there is a significant positive and high-impact correlation between the level of content knowledge, pedagogical knowledge and attitudes toward teacher readiness. The study on teachers' willingness to teach the PEERS curriculum is expected to benefit teachers teaching HE in the Malaysia Education system. This study gives the impression that teachers should be prepared mentally and physically to face challenges in implementing the new curriculum. This study can be used as a reference by the Ministry of Education Malaysia (MOE) to improve the quality of education and improve existing programs.
Star Formation History from Radio Observations: A New Look at an Important Cosmological Parameter

The radio wavelength luminosity of starburst galaxies correlates well with their star formation rates (Condon, 1992). Using this connection and three deep radio surveys, Haarsma and I constructed the global star formation history. Our results (see Haarsma et al., Ap. J., 2000 for details) show a steep increase from z == 0 to z == 1, matching calculations of the global SFR based on optical observations, when those observations have been corrected for the obscuration caused by dust. We note that our method requires no corrections for dust obscuration. We do, however, need to correct our results for radio emission from AGN. We do so using the extensive optical identifications available in these three fields.
BIG Modulates Stem Cell Niche and Meristem Development via SCR/SHR Pathway in Arabidopsis Roots

BIG, a regulator of polar auxin transport, is necessary to regulate the growth and development of Arabidopsis. Although mutations in the BIG gene cause severe root developmental defects, the exact mechanism remains unclear. Here, we report that disruption of the BIG gene resulted in decreased quiescent center (QC) activity and columella cell numbers, which was accompanied by the downregulation of WUSCHEL-RELATED HOMEOBOX5 (WOX5) gene expression. BIG affected auxin distribution by regulating the expression of PIN-FORMED proteins (PINs), but the root morphological defects of big mutants could not be rescued solely by increasing auxin transport. Although the loss of BIG gene function resulted in decreased expression of the PLT1 and PLT2 genes, genetic interaction assays indicate that this is not the main reason for the root morphological defects of big mutants. Furthermore, genetic interaction assays suggest that BIG affects the stem cell niche (SCN) activity through the SCRSCARECROW (SCR)/SHORT ROOT (SHR) pathway and BIG disruption reduces the expression of SCR and SHR genes. In conclusion, our findings reveal that the BIG gene maintains root meristem activity and SCN integrity mainly through the SCR/SHR pathway.
An integrative literature review of menstruation patterns in people with congenital adrenal hyperplasia

Abstract:Congenital adrenal hyperplasia (CAH) encompasses a range of inherited autosomal recessive enzyme conditions that impact steroid hormone production. This lifelong condition has associated health risks for some individuals, including adrenal crisis, and menstruation and fertility issues. Health literacy materials focused on the physical and pharmacological aspects of managing menstruation (i.e., treatment to initiate or maintain menses for those with CAH) are scarce. This article addresses this gap by exploring menses patterns in people with CAH. An integrative literature review searched articles published between 2005 and 2020, and 30 articles met inclusion criteria. Study findings indicated that while menarche seems to occur at an average age for people with CAH, menstruation is commonly disrupted and irregular. Several studies reported individuals achieving regular menses and pregnancy, while others noted individuals consistently showing poor control, irregular menses, and infertility despite ongoing treatment. A few studies reported such individuals as “non-adherent” or worse “non-compliant” with their medication regimens when health outcomes were lower than expected. We emphasize that such fault finding by health service providers around adherence acts as a barrier to communication with people with CAH. We argue that a sustained and coordinated person-centred approach focusing on communication and education across situational, developmental, and organizational transitions, can promote health literacy, foregrounding individuals’ health and bodily autonomy across their life span. Future research needs to address gaps in knowledge translation that supports menstrual education for individuals with CAH. Studies should also address how medication management is assessed and adherence negotiated with individuals with CAH.
Représentations p-adiques potentiellement cristallines

Ce travail fait suite a un article paru il y a quelques annees, dans lequel J.-M. Fontaine proposait une nouvelle description, en termes de (φ,Γ)-modules, des representations p-adiques du groupe de Galois d'un corps local dont le corps residuel est parfait de caracteristique p. On s'interesse ici plus particulierement aux representations cristallines et on etablit un critere, qui se lit sur le (φ,Γ)-module, permettant de reconnaitre si une representation p-adique est cristalline ou potentiellement cristalline, dans un cas particulier.
Insights into a Recovery Community Center Model: Results from Qualitative Interviews with Staff and Member Facilitators from Recovery Cafe in Seattle, Washington

ABSTRACT Many people living with substance use disorder require multiple types of support to reduce use and mitigate harms. Recovery community centers have emerged alongside formal substance use treatment and mutual self-help groups as another option to support peoples’ recovery. Research on the helpfulness of recovery community centers is limited. The purpose of this paper was to describe what Staff and Member Facilitators perceived as helpful components of a recovery community center. Semi-structured interviews were conducted with 10 Staff and six Member Facilitators of a recovery community center, Recovery Café, in Seattle, Washington. Qualitative interviews were analyzed via grounded theory approach. Eleven themes emerged on the helpful components of Recovery Café, including tangible/infrastructure and intangible/experiential strengths. Three themes related to opportunities for program improvement. Many themes on the helpful components were consistent with prior research on recovery community centers and other supports for recovery. Findings provide insight into potential active ingredients and mechanisms of recovery community centers and highlight the potential role of recovery capital. Additional research is needed to test these components to improve the understanding of if and how recovery community centers work to support people with substance use disorders in recovery.
Effect of Processing on the Antinutrient Content of Extruded Snacks from Cocoyam –Bambara Groundnut Flour Blends

Snacks from the blends of cocoyam and Bambara groundnut composite flour blends were developed through extrusion cooking Technology. Response Surface Methodology (RSM), formulations, and optimization of the process variables. The objective was to establish the optimum level of the effects of feed blend composition (X1), barrel temperature (X2), and feed moisture contents (X3) processing on the antinutrients composition of the composite flour blends. The responses were tannin, oxalate, phytates, and trypsin inhibitor. From the results, the tannin content ranged from 0.00 mg/100 g to 0.03 mg/100 g, oxalate 0.18 mg/100 g to 0.25 mg/100 g, phytate 0.23 mg/100 g to 0.69 mg/100 g and trypsin inhibitor 0.12mg/100g to 0.19mg/100g. These studies showed a significant difference (P≤ 0.05) for all the processing variables on all the responses. The studies show that high temperatures and low moisture content have the optimum effects on the antinutrient content.
Using L1 in the teaching of English as a foreign language

The recent discussion of the use of L1 in teaching English as a foreign language (EFL) has now focused on how to use the L1 effectively. Most researchers and advocates agree that L1 use is inevitable because it is a natural part of language teaching activities. Although many have suggested that language educators should be able to use L1 in the classroom wisely and judiciously, not many researchers have done investigated the ideal way to use L1. Employing a qualitative approach, this research focuses on investigating the factors encouraging three English lecturers to use L1 during their teaching activities in an Indonesian university. A semi-structured interview was employed to collect the data and, then, the data was analyzed using the narrative analysis approach. The findings reveal that the three English lecturers use L1 in their teaching activities in the classroom depending on some basic factors. The factors encompass the students’ mood, English proficiency level of the students, level of subject difficulty, students’ motivation, and classroom atmosphere. The result of the study challenges the advocates who support the use of full English instruction in the classroom activity to reconsider their theory. It is suggested that a future study should be conducted in the same field by involving a bigger number of participants from different universities and employing more than one data collection method. In addition, a future investigation about the effect of L1 use on the students’ achievement is also worth conducting.
Discrete conformal approximation of complex earthquake maps

Abstract : Using the techniques of circle packing, we construct discrete conformal approximations for complex earthquake maps on the Teichmueller spaces of compact, hyperbolic Riemann surfaces developed by William Thurston and Curtis McMullen, and we show that these approximations are convergent. We then describe earthquake maps on the Teichmueller spaces of compact, Euclidean Riemann surfaces, extending the work of Thurston and McMullen. Using the discrete conformal approximations developed for hyperbolic surfaces, we approximate the action of these new maps with circle packing.
Solid Digestate—Mathematical Modeling of Combustion Process

The combustion of waste biomass is becoming a key challenge for the energy sector, especially in times of growing energy demand and increasing environmental awareness of society. Processing such fuels is usually demanding. Mathematical modeling makes it possible to adapt the course of the process. The best option is to use appropriate fuel mixtures. The aim of this work was to develop a simple model that would allow the pre-selection of the mixture of two types of digestate. Residues from methane fermentation of maize and apple pomace were used in the study. The paper presents both a mathematical model and laboratory tests. The practical part was to check the validity of the model estimates. The model works on the basic data from physicochemical analysis. Laboratory tests included combustion of the samples of different mixtures. We used image analysis of thermograms to determine changes during combustion, which allowed us to determine when and where the main combustion occurs. Results show that a simple mathematical model is able to estimate the course of the combustion of a fuel particle.
effect of training models and flexibilities on the performance of service in sepaktakraw game

ABSTRACT This study aimed to look at the differences in the effect of exercise models and leg flexibility on service performance in sepaktakraw games. This research was conducted at FIKK UNG Gorontalo. The method used was an experimental method with a 2x2 simple factorial design. Through simple random sampling, this study involved a number of 40 samples. The results showed that: 1) The gradual training model had a better influence on the performance of upper service in a sepaktakraw game than that of the actual service training model (p <0.05), 2) For the group of high limb flexibility, the gradual training model had a better effect on performance top service in sepaktakraw games than the actual service training model (p <0.05), 3) For low flexibility, the actual service training model has a better effect on the performance of top service in sepaktakraw games than the gradual service training model (p <0.05), 4) There is an interaction between the training model and the flexibility of top service performance in sepaktakraw play (p <0.05).
Time to healthcare seeking following the onset of symptoms among men and women attending a sexual health clinic in Melbourne, Australia

Background Timely diagnosis and treatment of sexually transmitted infections (STIs) underpin their control by reducing the duration of infectiousness. There are currently limited data exploring healthcare seeking among individuals with STI symptoms. Methods We analyzed data on individuals reporting STI symptoms at the Melbourne Sexual Health Centre (MSHC) between August 2017 and December 2020. We calculated the time between symptom onset and clinic attendance by risk group for 13 STI diagnoses. We performed univariable and multivariable logistic regression analyses to explore factors associated with delayed healthcare seeking (greater than 7 days). Results Among 7,032 symptomatic clinic attendances, the shortest time to healthcare seeking was among individuals diagnosed with gonococcal urethritis (median 3 days), and the longest was among individuals diagnosed with genital warts (median 60 days). Individuals diagnosed with gonococcal urethritis sought care earlier than individuals diagnosed with non-gonococcal urethritis (median 3 vs. 6 days, p < 0.001), and individuals diagnosed with genital herpes sought care earlier than individuals diagnosed with primary syphilis (median 4 vs. 14 days, p < 0.001). Men who have sex with men, and men taking human immunodeficiency virus pre-exposure prophylaxis (PrEP), were least likely to delay healthcare seeking. Both men and women who delayed healthcare seeking were more likely to live further from the clinic than those who did not delay their presentation [ptrend < 0.001 (men) and ptrend = 0.049 (women)]. Conclusion Improved local access to healthcare alongside targeted strategies to encourage early healthcare seeking among groups at increased likelihood of delay may reduce STI-associated morbidity and transmission.