Miracle-dz/UniFAR-FTUs huggingface dataset:
Sustainability and switching of biologics for psoriasis

Background: The optimal treatment guidelines for psoriasis using biologics are limited. In addition to this, the administration of the original biologic may be terminated or switched to another biologic due to inefficacy, adverse effects, and economic burden. Our objective is to compare demographic characteristics between switched and non-switched groups and to identify the reason for switching among various original biologics in our setup. Methods: We performed a retrospective cohort analysis of psoriatic patients on biologic treatment. Our analysis involved 42 patients, of which 19 were switched to the second biologic. The demographic characteristics and reason for biologic switching were noted and data analyzed between switched and non-switched groups. Results: First line therapies were infliximab (IFX, n=10), etanercept (ETN, n=21), secukinumab (SEC, n=11) and switching required in 3 (30%), 11 (52%), 5 (45%) patients respectively. The reason for switching, in general, in our setup is inefficacy (n=10; 53%), non-availability (n=8; 42%) and adverse event (n=1; 5%). Small number of patients, single-centre study and retrospective design were the limitations. Conclusions: Infliximab showed the least tendency to switch to the second biologic, however, it had adverse reactions. Inefficacy is the primary cause of switching. To the best of our knowledge, our study on Biologics switching is the first of its kind in the Indian scenario.
Growth Inhibition of Selected Aquatic Bacteria by Tannic Acid and Related Compounds

Abstract Tannic acid, propyl gallate, methyl gallate, and gallic acid were tested for their inhibitory effects on selected aquatic microorganisms by the well assay technique. Tannic acid, propyl gallate, and methyl gallate in deionized water inhibited the growth of Aeromonas hydrophila, A. sobria, Edwardsiella iclaluri, E. tarda, Pseudomonas fluorescens, and Escherichia coli, but gallic acid did not. When 500-μg/mL concentrations of these four compounds were tested in sterilized fish pond water at pH 7.0 and with a low bacterial inoculum of 103–104 colony-forming units (CFU) per milliliter, they inhibited the growth of P. fluorescens and (except for tannic acid) E. coli. Pseudomonas fluorescens inoculated at 103–104 CFU/mL in pond water was inhibited by methyl gallate, propyl gallate, and tannic acid concentrations as low as 50 μg/mL, but a gallic acid contration of 100 μg/mL was required for inhibition. Escherichia coli was inhibited by methyl gallate and propyl gallate at 250 μg/mL and by gallic acid at.
Academic leadership: Perceptions of academic leaders and staff in diverse contexts

Universities have been coping with various challenges and pressures over the last decade. Therefore, capacity building for academic leaders is a critical point for universities to survive in this challenging era. Yet, existing studies suffer from several limitations. Among others, they do not consider the examination of academic staff members’ and leaders’ perceptions from diverse contexts, thus capturing insight into current practices. Using a qualitative study, we explored the perceptions of 18 academic staff members and leaders from eight Chinese and European universities, under which the perceived concept, a profile of effective academic leadership, and the motivators to become academic leaders from cross-cultural perspectives were emphasized. The results demonstrated that academic staff and leaders widely perceive the notion of academic leadership in diverse contexts as a complex concept. In addition, the findings provided several insights into understanding the profile of an effective academic leader who possesses a range of capacities and specific leadership styles. Furthermore, significant motivators that stimulate academic staff and leaders to pursue academic leadership positions were also examined and discussed. The results of this study can serve as a stepping stone for designing the framework used in leadership development programs as well as for collaboration in capacity development for university academic leaders.
RETINAL GANGLION CELL SIZE AND DISTRIBUTION PREDICT VISUAL CAPABILITIES OF DALL'S PORPOISE

The structure of the retina, the distribution of ganglion cells, and the extent of the tapetum lucidum were studied in Dall's porpoise (Phocoenoides dalli) with the aim of understanding the role vision plays in this species of cetacean. The basic organization of the retina was similar to that of other vertebrates. Average ganglion cell size was 21.5 μm. The distribution of the ganglion cells in the retina was not even and there were two high-density areas, one in the temporal and one in the rostral part of the retina. Retinal resolving power was estimated using a terrestrial animal model incorporating the density of ganglion cells and other morphological data. The resolving power in the right eyes of two individuals was 2.60 and 2.64 cycles per degree. These values were close to those of other oceanic cetaceans, but inferior to those of terrestrial mammals. On the basis of amino acid analyses, it was shown that the choroid tapetum lucidum in Dali's porpoise contained collagen. The tapetum lucidum was thick at the fundal but thin at the peripheral part of the choroid.
Antioxidant and metabolic responses induced by cadmium and pyrene in the earthworm Eisenia fetida in two different systems: contact and soil tests

The effects of cadmium and the polycyclic aromatic hydrocarbon (PAH) pyrene on the earthworm Eisenia fetida were investigated in contact and soil tests. Metabolic (glutathione-S-transferase, GST) and oxidative (catalase, CAT) stress enzymes were studied as biomarkers in earthworms after 48 hours, 14 days and 28 days. Contact test indicated that cadmium had significant effects on survival and enzyme activities while pyrene influenced neither in the studied concentrations. Induction of CAT and GST in earthworms exposed to cadmium and pyrene in the acute soil test (14 d) revealed the metabolism of these chemicals resulting in the production of reactive oxygen species. After a relatively long period of exposure (28 d), earthworms exposed to pyrene failed to handle the high toxicity and were physiologically damaged, while those exposed to cadmium adapted to the disturbed environment through effective metabolism of the chemical and management of the oxidative stress.
It Takes a Village: Understanding African American High School Students’ Self-Determination in School

Abstract The present study examined African American high school students’ perceptions of their development and use of self-determination skills (e.g., goal setting, choice/decision making, self-advocacy, etc.) in school. The term development refers to the cultivation of self-determination skills through various means (e.g., structured learning opportunities), and the term use refers to students actually employing the skills in school and other settings across time. We conducted four focus group interviews with a predominately African American female sample to examine (a) how various self-determination skills contributed to their success in school and (b) how they developed these skills through community-based support. Key findings indicate that the participants perceived their use of multiple self-determination skills as facilitating their success in school by helping them (a) be independent, (b) remain motivated in school, (c) prioritize their time, and (d) receive support from classroom teachers. Through their involvement in community-based programs, the participants developed the skills through hands-on activities, group discussions, field trips (e.g., college visits), and interacting with peers in their community organization. Findings from this research support calls for educators to promote African American students’ self-determination while taking a culturally responsive approach by collaborating with local community-based organizations that were developed to support these students.
Protein kinase C δ is a critical regulator of CD1d‐mediated antigen presentation

We have recently demonstrated that the p38 and ERK1/2 MAP kinases play reciprocal roles in the control of CD1d‐mediated antigen presentation. Although the use of specific inhibitors for these pathways clearly had an effect, the effects were not complete, leading to speculations that additional pathways were involved. Here, we show that inhibiting protein kinase C δ (PKCδ) substantially impairs antigen presentation by murine CD1d1 to NKT cells. This effect was accompanied by marked changes in the intracellular localization of CD1d. Expression of a dominant‐negative mutant of PKCδ in CD1d+ cells resulted in nearly undetectable endogenous antigen presentation, substantially impaired CD1d recycling, a decrease in MAPK activation, and a decrease in the ability to present low (but not high) concentrations of α‐galactosylceramide at the cell surface. These data strongly suggest that PKCδ is a critical regulator of CD1d‐mediated antigen presentation and is involved in multiple steps of the process.
SEXUAL PREFERENCES OF FEMALE BROWN-HEADED COWBIRDS (MOLOTHRUS ATER) FOR PERCHED SONG REPERTOIRES

Abstract The importance of repertoire size to mate choice by female songbirds has been widely debated but has not been addressed in Brown-headed Cowbirds (Molothrus ater; hereafter ”cowbirds”), despite extensive work on this species' songs. Male cowbirds cycle through repertoires of 2–8 perched song (PS) types in rapid sequences immediately prior to and during copulation, which suggests that repertoire size or content is important in mating contexts. Because male mating success in one well-studied cowbird population is correlated with large PS repertoires, we predicted that repertoire size is a cue in female mate choice. To test that prediction, we played three repetitions of conspecific songs in rapid succession to estradiol-primed female cowbirds (M. a. obscurus), to simulate the rapid song sequences that accompany naturally occurring matings. Females were presented with three different PS types, three repetitions of the same type, and heterospecific control songs of the same duration as the conspecific playbacks. Females gave longer copulation solicitation displays to three different PS types than to three repetitions of a single PS type, regardless of whether the playback songs were local or foreign. This is one of the few experimental studies on songbirds to show greater female responsiveness to a song repertoire presented so as to mimic singing in a natural mating context, and the first to present such a result for cowbirds. We conclude that presentation of multiple PS types is more sexually stimulating to females than a single type, because females prefer larger repertoires or singing patterns with a higher frequency of song-type switching. Preferencias Sexuales de Hembras de Molothrus ater por Repertorios de Canto de Percha
Problematic internet use: Media portrayal across eight countries

The informational age is marked by the Internet and the media as key factors, with complex mutual interactions. However, they are recognized to increasingly produce negative consequences, such as Problematic Internet Use (PIU) and its inadequate media portrayal. This study represents a comprehensive approach on the media portrayal of PIU via content analysis of national daily newspapers in eight countries from the Eurasian continent. The cross-sectional research included predefined intervals in 2014 and 2018. The search retrieved 212 articles with balanced distribution for designated periods, and predominant publishing in the largest countries. The results revealed that the articles with neutral narratives and national scopes are the most frequent, while the coverage on youth risks (like cyberbullying and excessive social media use) is predominant. This study is a pioneer attempt to give multinational and multi-layered portrayal on the stories that grab the media attention, dictate public interest and guide health policies.
Overexpression of Strigolactone-Associated Genes Exerts Fine-Tuning Selection on Soybean Rhizosphere Bacterial and Fungal Microbiome

Strigolactones are a recently discovered class of carotenoid-derived plant hormones with a wide variety of functions, including acting as signaling molecules in the rhizosphere to promote arbuscular mycorrhizal fungi colonization and parasitic seed germination. To determine whether strigolactones influence the recruitment of microbes to the rhizosphere, we characterized both bacterial and fungal communities in response to the overexpression of genes involved in strigolactone biosynthesis (MAX1d) and signaling perception (D14 and MAX2a) in soybean (Glycine max). The amplicon sequencing-based results suggest that strigolactone overexpression lines had altered soybean rhizosphere bacteria composition at both the community level and individual taxa level with genera including Shinella and Bdellovibrio consistently more abundant across all three overexpression constructs. In addition, the responses of the soybean rhizosphere bacteria community differed significantly across the genes, with lines overexpressing genes involved in strigolactone biosynthesis (MAX1d) yielding a divergent bacterial community in comparison with those with altered expression of strigolactone perception genes (D14 and MAX2a). The overexpressed genes did not significantly impact the overall fungal community distribution; however, some individual taxa were altered in abundance. MAX1d and D14 overexpression lines had significantly enriched abundance of Fusarium solani. The mediating role of strigolactone biosynthesis and signaling genes on soybean rhizosphere bacterial and fungal communities confirmed strigolactone’s importance in the rhizosphere host–microbe communication and microbial community structure. [Formula: see text] Copyright © 2020 The Author(s). This is an open access article distributed under the CC BY-NC-ND 4.0 International license .
Sesquiterpenes of the Essential Oil of Pinus sylvestris

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Forecasting Bitcoin using Double Exponential Smoothing Method Based on Mean Absolute Percentage Error

Abstract— After being introduced in 2008, the rise in the price of bitcoin and the popularity of other cryptocurrencies triggered a growing discussion about how much energy was consumed during the production of this currency. Making cryptocurrency the most expensive and most popular, both the business world and the research community have begun to study the devel-opment of bitcoin. In this study bitcoin price predictions are performed using the double exponential smoothing method based on the mean absolute percentage error (MAPE). The MAPE value is used to find the best alpha (α) parameter as the basis for bitcoin price forecasting. The dataset used is the price of bitcoin from 2017 to 2019. The dataset was obtained from www.cryptocompare. com. As for the value of the alpha parameter (α), using a value of 0.1 to 0.9. Based on the test results using the double exponential smoothing method obtained the smallest MAPE value of 2.89%, with the best alpha (α) at 0.9. The prediction is done to see the price of bitcoin on January 1, 2020. The error rate generated on the predicted price of bitcoin uses an amount of 0.0373%. This shows that the system built can be used as a support for decision making when trading bitcoin.
Catch-effort maximum likelihood estimation of important population parameters

The relative ease with which linear regression models are understood explains the popularity of such techniques in estimating population size with catch-effort data. However, the development and use of the regression models require assumptions and approximations that may not accurately reflect reality. We present the model development necessary for maximum likelihood estimation of parameters from catch-effort data using the program SURVIV, the primary intent being to present biologists with a vehicle for producing maximum likelihood estimates in lieu of using the traditional regression techniques. The differences between the regression approaches and maximum likelihood estimation will be illustrated with an example of commercial fishery catch-effort data and through simulation. Our results indicate that maximum likelihood estimation consistently provides less biased and more precise estimates than the regression methods and allows for greater model flexibility necessary in many circumstances. We recommend.
Communicating the experience of chronic pain through social media: patients’ narrative practices on Instagram

ABSTRACT Background: The use of technologies in health is changing the relationship between patients and their conditions. In the case of chronic pain, social media are offering these individuals a new way to talk about their experience. The objective of this paper is to identify how and why patients are using these online platforms for pain communication. Particularly, this study analyses self-expression practices of this disease on Instagram. Method: A sample of posts was selected from the platform following a multistage sampling strategy (n = 350). These publications were examined through a qualitative analysis based on multiple categories related to the experience of chronic pain. Results: Patients are using Instagram to give visibility to illnesses such as fibromyalgia or endometriosis. Moreover, these individuals talk about their condition in terms of chaos and uncertainty, using the narratives to construct a world that gives meaning to their chronic pain. However, men are largely absent from these online practices. Ninety-four percent of the publications included in the sample were shared by women (n = 329). Conclusion: Findings indicate that Instagram is changing the way patients live with their chronic pain. Considering the complexity of this condition, care providers could improve the assessment of chronic pain by paying more attention to the self-expression practices of these individuals.
Imaginal induction of diapause in several ‘adult‐female diapausing’ spider mites

Abstract. The possibility of imaginal induction of diapause in adult female spider mites is suggested in Stigmaeopsis miscanthi. Here, several spider mites are studied to investigate the generality of this phenomenon. The existence of imaginal induction of reproductive diapause is established in Stigmaeopsis longus, two forms of S. miscanthi and Tetranychus kanzawai adult females. The females that develop under diapause‐averting (long days and 18 °C) conditions are induced to diapause under short‐daylength conditions at 18 °C after moulting to the adult stage. However, the adult females of Tetranychus urticae never diapause under these conditions.
Investigation of the relationship between burnout, life satisfaction and quality of life in parents of children with disabilities

ABSTRACT The aim of this study was to investigate the relationship between burnout, life satisfaction and quality of life in parents of disabled children and the mediating role of burnout in the relationship between life satisfaction and quality of life. Relational comparison, which is a quantitative research method, was used. The study sample consisted of 538 parents of students with disabilities of special education schools in the central district of Düzce and parents of children with disabilities receiving services from the Guidance Research Centre. Data were collected using the Maslach Burnout Inventory, the Beach Centre Family Quality of Life Scale and the Satisfaction with Life Scale. Pearson Product Moment Correlation Coefficient and path analysis model were used for analysis. Burnout was negatively correlated with life satisfaction and quality of life while the quality of life was positively correlated with life satisfaction. Quality of life predicted burnout negatively while burnout predicted life satisfaction negatively. However, the quality of life did not predict life satisfaction. According to path analysis, burnout was a mediating variable. Results suggest that parents of children with disabilities should be supported socially and financially and that existing social support should be diversified based on the child’s disability.
THE EFFECT OF OWNERSHIP STRUCTURE ON INVESTMENT EFFICIENCY (CASE STUDY IN NON FINANCIAL FIRMS LISTED ON INDONESIA STOCK EXCHANGE IN 2015-2017)

Histori Artikel : Tgl. Masuk : Tgl. Diterima : Tersedia Online : The objective of this study is to investigate whether ownership structure and corporate governance affecting the efficiency of investment of listed non-financial firms in Indonesia. Ownership concentration, managerial ownership, management stock option, and mutual funds ownership used as independent variables in this study. Meanwhile, the dependent variable in the research is investment efficiency. Regression analysis is used as a method in analyzing secondary data obtained by using purposive sampling method. Secondary data used in research sourced from the financial statements and annual reports of non-financial companies listed on the Indonesia Stock Exchange in 2015-2017. The result of this research indicates that ownership concentration does not have a significant influence towards investment efficiency. This result also shows that each of managerial ownership and management stock options positively influence investment efficiency. Furthermore, mutual funds’ ownership is proven that positively influence the investment efficiency