Miracle-dz/UniFAR-FTUs huggingface dataset:
Analysis of the Chemotherapy-Free Interval following Image-Guided Ablation in Sarcoma Patients

One way to enhance quality of life for patients with metastatic sarcoma is to maximize time off chemotherapy—a chemotherapy-free interval. While image-guided ablation of sarcoma metastases may reduce the need for chemotherapy, it remains unknown how long ablation could extend the chemotherapy-free interval. The purpose of our study was to determine the chemotherapy-free interval in comparison to overall survival and progression-free survival in sarcoma patients who undergo ablation procedures. An IRB-approved, single institution, HIPAA compliant database was queried for sarcoma patients who underwent image-guided ablation procedures between 2007 and 2018. Patient demographics, histologic subtype, and other clinical characteristics were recorded. Kaplan-Meier analysis was performed to compute median overall survival, median progression-free survival (local and distant), and the median chemotherapy-free interval (systemic and cytotoxic) after ablation. Univariate and multivariate analyses were performed using the log-rank test and Cox proportional-hazards model, respectively. A total of 100 sarcoma patients were included in the analysis. The most common histologic subtype was leiomyosarcoma (38%). Median overall survival after ablation of sarcoma metastases was 52.4 months (95% CI: 46.9–64.0 months). The median systemic chemotherapy-free interval following ablation of sarcoma metastases was 14.7 months (95% CI: 8.6–34.3 months). The median cytotoxic chemotherapy-free interval following ablation of sarcoma metastases was 81.3 months (95% CI: 34.3-median not reached). In conclusion, ablation of sarcoma metastases can provide an extended systemic chemotherapy-free interval of greater than 1 year. Ablation of sarcoma metastases may improve patient quality of life by extending the chemotherapy-free interval.
Screening and Assessment of Potential Plant Growth-promoting Bacteria Associated with Allium cepa Linn.

Plant growth-promoting bacteria (PGPB) are beneficial microbes that increase plant growth and yield. However, limited information is currently available on PGPB in onion (Allium cepa Linn.). The aims of the present study were to isolate and identify PGPB in onion and examine the effects of isolated PGPB on germination and growth during the vegetative stage in onion, pak choy (Brassica chinensis), and sweet pepper (Capsicum annuum). Twenty-three strains of PGPB were isolated from the roots, bulbs, and rhizosphere soil of onion. All isolated bacterial strains showed one or more PGP traits, including indole acetic acid production, phosphate solubilization ability, and 1-aminocyclopropane-1-carboxylate deaminase and nitrogenase activities; most of these traits were derived from Bacillus sp. , Microbacterium sp. , and Pseudomonas sp. Eight bacteria that exhibited strong abilities to produce indole acetic acid were selected for a Petri dish trial, soil pot test, and vermiculate pot test. The Petri dish trial showed that strains ORE8 and ORTB2 simultaneously increased radicle and hypocotyl lengths in onion, but inhibited growth in sweet pepper after 7 d. The soil pot experiment on onion revealed that strains ORE5, ORE8, and ORTB2 strongly promoted growth during the vegetative stage with only a half dose of chemical fertilizer. The present results indicate that ORE8 (Bacillus megaterium) and ORTB2 (Pantoea sp.) are the most promising biofertilizers of onion and may simultaneously inhibit the seedling growth of other plants.
SABER, VALORAR Y ACTUAR: RELACIONES ENTRE INFORMACIÓN, ACTITUDES Y CONSUMO DE ALCOHOL DURANTE LA GESTACIÓN KNOWING, VALUING AND ACTING: RELATIONSHIPS BETWEEN INFORMATION, ATTITUDES AND DRINKING DURING PREGNANCY

Resumen Drinking alcohol during pregnancy can lead to different problems with different levels of severity, encompassed by the term Fetal Alcohol Spectrum Disorders. Considering that a safe dose of alcohol during pregnancy has not been determined, the official recommendation of various national and international organizations is abstinence. However, the evidence indicates that although many women are aware that alcohol can alter fetal development, most of them believe that some consumption during pregnancy is acceptable. Through this study, we intend to contribute to the understanding of the relationship between knowledge, attitudes and drinking during pregnancy. To achieve this, we analyze semi structured interviews carried on with puerperal women in Argentina (n = 641). 70.4% of women reported having received some information about a potential adverse effect of alcohol consumption during pregnancy, but few of them had accurate information and only 6.1% mentioned a health professional as source. Information and attitudes were strongly linked. Attitudes were significantly associated to some alcohol consumption during pregnancy and to binge drinking during that period.
Self-compassion and responses to health information in middle-aged and older women: An observational cohort study

The aim of this study was to determine whether self-compassion—orientation to care for oneself during challenges—helps people at risk of cardiovascular disease deal with emotional reactions and assist with self-regulating health behaviors. This observational study recruited women (N = 102) who attended three research visits over 3 weeks to gather information on emotions, intentions, and engagement in health behaviors after women received news they were at risk of cardiovascular disease. Self-compassion negatively associated with emotional responses and associated with intentions and engagement in health behaviors after receiving news of their cardiovascular disease risk. Self-compassion was associated with adaptive lifestyle behaviors.
Effect of Competition Frequency on Strength Performance of Powerlifting Athletes.

Pearson, J, Spathis, JG, van den Hoek, DJ, Owen, PJ, Weakley, J, and Latella, C. Effect of competition frequency on strength performance of powerlifting athletes. J Strength Cond Res XX(X): 000-000, 2020-Powerlifting (PL) requires athletes to achieve the highest possible "total" weight lifted across squat, bench press, and deadlift. Athletes compete multiple times per year; however, it is not well understood how often PL athletes should compete to facilitate maximal strength performance. This study investigated the effect of competition frequency on strength (relative and absolute) in PL athletes over a 12-month period. Results across all male (n = 563, mean ± SD; age; 28 ± 10 years, body mass; 89.3 ± 19.3 kg) and female (n = 437, age; 31 ± 11 years, body mass; 70.1 ± 15.8 kg) PL athletes were collated. Total competition scores were used to calculate absolute and relative strength for each competition. Linear mixed models with random effects, and effect sizes ± 95% confidence intervals compared competition frequency and total score for (a) all, (b) male, and (c) female competition entries, respectively. The association between total score at each competition was assessed with Pearson's correlation coefficient for the same independent variables. Results demonstrate greater absolute strength at competition 2 for all athletes (5.1%: p = 0.043: d = 0.16) and males (2.9%: p = 0.049: d = 0.15). For females, absolute strength was greater at competition 5 compared to 1 (12.0%: p = 0.001: d = 0.65) and 2 (9.6%: p = 0.007: d = 0.50). Weak positive correlations for relative strength and number of times competed for males were evident between competitions 1 to 4 (r = 0.070-0.085, p = 0.003-0.043). For females, 3 competitions weakly correlated with absolute strength (r = 0.106, p = 0.016). PL athletes who compete multiple times per year are more likely to achieve higher totals; however, there is an upper limit to the number of competitions (4 per year) that seem to allow a performance increase.
Synchronization Analysis for Complex Dynamical Networks With Coupling Delay via Event-Triggered Delayed Impulsive Control

This article deals with the exponential synchronization problem for complex dynamical networks (CDNs) with coupling delay by means of the event-triggered delayed impulsive control (ETDIC) strategy. This novel ETDIC strategy combining delayed impulsive control with the event-triggering mechanism is formulated based on the quadratic Lyapunov function. Among them, the event-triggering instants are generated whenever the ETDIC strategy is violated and delayed impulsive control is implemented only at event-triggering instants, which allows the existence of some network problems, such as packet loss, misordering, and retransmission. By employing the Lyapunov–Razumikhin (L–R) technique and impulsive control theory, some sufficient conditions with less conservatism are proposed in terms of linear matrix inequalities (LMIs), which indicates that the ETDIC strategy can guarantee the achievement of the exponential synchronization and eliminate the Zeno phenomenon. Finally, a numerical example and its simulations are presented to verify the effectiveness of the proposed ETDIC strategy.
Calf- and herd-level factors associated with dairy-calf reactivity.

A positive relationship between handlers and animals in farm systems is essential because the human-animal relationship has implications for welfare and productivity. For this reason, on-farm animal welfare assessment protocols often include the behavioral response of animals to humans to measure the quality of the human-animal relationship. The existing literature has described this relationship as having a multifactorial nature. In the current study, we aimed to investigate the potential influence of farm management and infrastructure characteristics, calf manager traits, and intrinsic features of dairy calves on the human-animal relationship. To this end, an escape test was conducted with 698 calves on 30 dairy farms in Chile. This test measured the calf's response to the active approach of an unfamiliar human (and was scored from 0 [fearful] to 4 [friendly]). The explanatory variables used to predict calves' response in the escape test were grouped according to the following categories: (1) farm management and infrastructure (e.g., calf-dam separation age, space allowance); (2) calf manager (e.g., attitudes, behavior, and background); and (3) calf (e.g., breed, sex, age). We concluded that calf managers with additional jobs on the farm, no training, low job satisfaction, a greater proportion of negative contacts, and more negative attitudes were predictive of fearfulness in the escape test. Holstein breed (compared with Holstein and Jersey crossbreeds) was associated with greater odds of fearful calves. Our study confirms the association between animals' fear and handlers' features, which can potentially be used to select employees on a farm. Understanding the factors that influence fear responses in calves may highlight ways to improve the relationship between animals and humans.
Rising Incidence of Sporadic Vestibular Schwannoma: True Biological Shift Versus Simply Greater Detection.

OBJECTIVE The incidence of sporadic vestibular schwannoma (VS) has increased significantly over recent decades. The rising incidence of VS has been largely attributed to the increasing use of magnetic resonance imaging (MRI), especially with regard to incidentally diagnosed tumors. However, no study to date has directly investigated this supposed etiology beyond the observation that VS incidence rates have risen in the post-MRI era. Therefore, the primary objective of the current study was to characterize the incidence of head MRIs over the previous two decades in Olmsted County, Minnesota and compare this trend to the incidence of asymptomatic, incidentally diagnosed VS over the same time period. STUDY DESIGN Population-based incidence study. SETTING/PATIENTS Using the unique resources of the Rochester Epidemiology Project, procedure codes for head MRIs and diagnostic codes for VS among residents of Olmsted County, Minnesota between Jan 1, 1995 and Dec 31, 2016 were retrieved. Incidence rates of head MRI and incidentally diagnosed VS were calculated on a per-year basis. RESULTS A total of 43,561 head MRIs among 30,002 distinct persons were identified from 1995 to 2016. The incidence of head MRI significantly increased between 1995 and 2003 (p < 0.001), but remained stable between 2004 and 2016 (p = 0.14). Over the same time interval, 25 cases of incidentally diagnosed VS were identified. The incidence of asymptomatic VS increased over time from 0.72 per 100,000 person-years between 1995 and 1999 to 1.29 between 2012 and 2016 (p = 0.058). No plateauing of incidence rates was observed in incidental tumors over the study period. The size of incidentally diagnosed tumors did not change over the study period (p = 0.93), suggesting that the increasing incidence of asymptomatic tumors is not explained by improved diagnostic capability of more recent MRI studies. CONCLUSIONS Despite the plateauing of head MRI incidence rates after 2004, the incidence of asymptotic, incidentally diagnosed VS continued to increase. Our findings suggest that there may be additional contributory etiologies for the rising incidence of VS beyond greater detection alone.
Preparation and tribological behaviour of poly(methyl methacrylate) (PMMA) microcapsules containing friction modifiers

Abstract Aims: Microcapsules comprising of a poly(methyl methacrylate) (PMMA) shell and friction modifier (FM) core were prepared to reduce the friction and extend the service life of engine lubricating oil. Methods: Microcapsules containing both organic FM and molybdenum FM were produced via solvent evaporation technique. The friction coefficient, thermal stability, and chemical composition of microcapsules were investigated. Results: The incorporation of microcapsules in lubricating oil dramatically reduced the friction coefficient to be lower than that of virgin FM. Organic FM and molybdenum FM are compatible during the encapsulation process. The release of the FM inside the microcapsules was controllable by thermal degradation of polymeric shell at 150 °C or mechanical rupture at room temperature. Conclusions: This study provided a novel approach to improve the tribological properties of lubricating oil with long service life, facile fabrication and low cost and will find potential applications in lubrication industry for internal combustion engines.
The epidemiological and clinical characteristics of hand, foot and mouth disease in Hangzhou, China, 2016-2018

Background Hand, foot and mouth disease (HFMD) is most frequently caused by several serotypes of human enterovirus (EV) including Enterovirus 71 (EV71), Coxsackievirus A16 (CV-A16) or other types of EV. Children under 5 years old are the most susceptible to HFMD. The aim of this study was to determine the epidemiological characteristics and the relationship between severe and mild HFMD. Methods We collected 4760 probable HFMD cases with skin papular or vesicular rashes on the hands, feet, mouth or buttocks in Hangzhou from 2016 to 2018. Specimens of these cases were collected and the pathogen of EV71, CV-A16, CV-A6, CV-A10, CV-A2 and CV-A5 was classified by RT-PCR. Then the pathogen distribution and clinical status of children with HFMD were described. Results From Jan. 1, 2016 to Dec. 31, 2018, the incidence and prevalence of HFMD were seasonal each year. Among the 4760 probable HFMD cases, 3559 cases were confirmed (74.8%, 3559/4760), including 426 cases of EV71 infections (8.9%, 426/4760, 249 cases of CV-A16 infections (5.2%, 249/4760) and 2884 cases of other enteroviruses infections (60.6%, 2884/4760). The percentage of EV positive HFMD cases with non-EV71 and non-CV-A16 was more than 80% (2884/3559), which increased year by year. The percentage of EV71 decreased year by year in the last three years especially in 2018. Among the 1297 cases randomly selected of other EV infections in 2017 and 2018, there were 835 (64.4%) cases of CV-A6 infections, 177 (13.6%) cases of CV-A10 infections, 100 (7.7%) cases of CV-A2 infections, 40 (3.1%) cases of CV-A5 infections, 3 (0.02%) cases of mixed infections and 11.0% untyped enteroviruses infections. Preschool children were still the primary population susceptible to HFMD, and the age of the children infected with other enteroviruses tended to be younger. In severe cases, EV71 infection was the main cause. Conclusions The other EV especially CV-A6 increased obviously and EV71 decreased obviously in the three years. Characterizing the epidemiology and the relationship between severe and common cases of HFMD would provide relevant evidences for the prevention and treatment of HFMD.
Calcium-sorbitol Chelating Technology and Application in Potatoes

Researches on low-molecular organic compounds are concentrated in amino acid and Humic acid chelating fertilizer, but few in sorbitol chelated calcium. In this study, selecting sorbitol as chelating agent, the technological conditions of chelating sorbitol with calcium and the effect of sorbitol chelated calcium on potato were studied. The impact factors on the stability of the fertilizer were investigated, including sorbitol dosage, pH value, chelating time and temperature. Then a field experiment was conducted on potato. Three treatments included water sprayed as a control, calcium nitrate and sorbitol chelated calcium sprayed. Each treatment had three replicates. The results showed that by orthogonal experiments, the sorbitol dosage has the greatest influence on the stability of the chelating system. The optimum conditions for the synthesis were determined as follows: The sorbitol dosage of 12 g, the chelating temperature of 50°C, the pH of 4 and the chelating time of 45 min. Compared with those of potatoes fertilized with inorganic calcium nitrate, the yield of potatoes sprayed with sorbitol chelated calcium increased by 14.23% and their marketable tuber percentage increased by 3.58%; the nitrate nitrogen content in potatoes decreased by 11.89%; the accumulation of phosphorus and potassium in potato tubers increased. Generally, the application effect of our prepared sorbitol chelated calcium on potato was remarkable.
Factors Associated With Potentially Missed Diagnosis of Appendicitis in the Emergency Department

Key Points Question What factors are associated with a potentially missed diagnosis of appendicitis in the emergency department among adults and children? Findings In this cohort study of 123 711 patients diagnosed with appendicitis, insurance claims data indicated that appendicitis was potentially missed in 6.0% of adults and 4.4% of children during the initial emergency department visit. Factors associated with potentially missed appendicitis included female sex, the coexistence of abdominal pain and constipation, and the presence of comorbidities. Meaning Population-based estimates of the rates of potentially missed appendicitis reveal opportunities for improvement and identify factors that may alert clinicians and mitigate the risk of missed diagnosis.
Meat Protein in High Fat Diet Induces Adipogensis and Dyslipidemia by Altering Gut Microbiota and Endocannabinoid Dysregulation in the Adipose Tissue of Mice.

Endocannabinoids modulate insulin and adipokine expression in adipocytes through cannabinoid receptors and their levels are elevated during hyperglycemia and obesity, but little is known about how diets affect them. We assessed the effects of dietary casein, chicken, beef and pork proteins in a high fat diet mode, on endocannabinoids, adipogenesis and biomarkers associated with dyslipemdia. A high fat beef or chicken diet upregulated cannabinoid 1 receptor,N-acylphosphatidylethanolamine-selective phospholipase-D and diacylglycerol lipaseα in adipose tissue, and reduced the immunoreactivity of mitochondrial uncoupling protein 1 in brown adipose tissue. In addition, the high fat diets with beef and chicken protein had a significant impact on adipocyte differentiation and mitochondrial biogenesis in obese mice. A 16S rRNA gene sequencing indicated that high fat diets, regardless of protein source, significantly enhanced the ratio of Firmicutes to Bacteroidetes in colon. Meat proteins in a high fat diet significantly decreased the relative abundances of Akkermansia and Bifidobacteria but enhanced lipopolysaccharides level in the serum, which promoted the adipogenesis process by causing dysregulation in the endocannabinoid receptors. Consumption of meat protein with high fat induced adiposity, visceral obesity, dyslipidemia, reduced the thermogenesis, and had a distinctive effect on the mitochondrial biogenesis compared to casein protein.
Utilizing Electroplex Emission to Achieve External Quantum Efficiency up to 18.1% in Nondoped Blue OLED

For the first time, electroplex emission is utilized to enhance the performance of nondoped blue organic light-emitting diodes (OLEDs). By decorating the twisted blue-emitting platform and adjusting the electronic structure, three molecules of 3Cz-Ph-CN, 3Cz-mPh-CN, and 3Ph-Cz-CN with a donor-acceptor structure are synthesized and investigated. When external voltage is applied, electroplex emission, which contributes to the emission performance of OLED, can be realized at the interface between the emitting layer and the electron-transporting layer. Accordingly, high external quantum efficiency of 18.1% can be achieved, while the emission wavelength of the device can be controlled in the blue region. Our results provide the possibility to enhance the performance of OLED through electroplex emission, in addition to the generally investigated thermally activated delayed fluorescence (TADF). Excitedly, when 3Ph-Cz-CN is used as host material in orange-emitting phosphorous OLEDs (PO-01 as the dopant), unprecedented high external quantum efficiency of 27.4% can also be achieved.
Qualitative Analysis of Knowledge, Attitudes, and Beliefs About Pessary Use Among Spanish-Speaking Women on the US-Mexico Border

Supplemental digital content is available in the text. Objectives To explore the knowledge, attitudes, and beliefs related to pessary use in Spanish-speaking women along the US-Mexico border. Methods Spanish-speaking women with symptoms of vaginal bulge were recruited from the urogynecology/gynecology clinics at Texas Tech University Health Sciences Center El Paso to participate in moderated focus groups. Discussion topics included knowledge of prolapse/pessaries, pros/cons of pessaries, alternatives, and prolapse surgery. Audio-recorded group discussions were transcribed verbatim, and qualitative analysis completed by independent review using grounded theory methodology. Common themes were identified and then aggregated to form consensus concepts, agreed upon by the reviewers. Results Twenty-nine Spanish-speaking women participated in 6 focus group discussions. Approximately half of women reported little or no prior knowledge about pessaries. Three main themes were identified from analysis: knowledge/perceptions, misinformation/misconceptions, and surgery-related concerns. Concepts identified from common themes included limited knowledge of pessaries, confusing “pessary” with “mesh,” willingness to try pessaries in order to avoid surgery, desire to try pessary if it was recommended by physician, limited efficacy or complications of surgery, and mesh-related concerns. Interestingly, some women reported that pessaries appear to be a treatment more often offered in the United States rather than in Mexico. Conclusions Most participants showed a willingness to try a pessary for symptoms of pelvic organ prolapse in an effort to avoid surgery, despite expressing limited knowledge about this treatment. Physician recommendations and risks of pessary use influence their likelihood of trying a pessary. These concepts serve as focus points for effective pessary counseling to help improve education and informed decision making in this patient population.