Miracle-dz/UniFAR-FTUs huggingface dataset:
A comparison of six weeks with six months of oral anticoagulant therapy after a first episode of venous thromboembolism. Duration of Anticoagulation Trial Study Group.

BACKGROUND The optimal duration of oral anticoagulant therapy after a first episode of venous thromboembolism is still a matter of debate. METHODS We performed a multicenter trial comparing six weeks of oral anticoagulant treatment with six months of such therapy in patients who had a first episode of venous thromboembolism. Anticoagulant therapy consisted of warfarin or dicumarol. Of the 902 patients enrolled, 5 were later excluded because they had congenital protein C deficiency; 443 were randomly assigned to receive six weeks of oral anticoagulant therapy with a targeted international normalized ratio (INR) of 2.0 to 2.85, and 454 were randomly assigned to receive six months of such therapy. The initial diagnoses were confirmed by means of venography in cases of deep-vein thromboses (n = 790) and with perfusion-ventilation scanning or angiography in cases of pulmonary embolism (n = 107); recurrences were confirmed in the same way. RESULTS After two years of follow-up, there had been 123 recurrences of venous thromboembolism that met the diagnostic criteria, 80 in the six-week group (18.1 percent; 95 percent confidence interval, 14.5 to 21.6) and 43 in the six-month group (9.5 percent; 95 percent confidence interval, 6.8 to 12.2). The odds ratio for recurrence in the six-week group was 2.1 (95 percent confidence interval, 1.4 to 3.1). There was no difference in mortality or the rate of major hemorrhage between the six-week and six-month groups. CONCLUSIONS Six months of prophylactic oral anticoagulation after a first episode of venous thromboembolism led to a lower recurrence rate than did treatment lasting for six weeks. The difference between the two groups occurred between 6 weeks and 6 months after the start of treatment, and the rates of recurrence remained nearly parallel for 1 1/2 years thereafter.
An analytical assessment of the porbeagle shark (Lamna nasus) population in the northwest Atlantic

1 This series documents the scientific basis for the evaluation of fisheries resources in Canada. As such, it addresses the issues of the day in the time frames required and the documents it contains are not intended as definitive statements on the subjects addressed but rather as progress reports on ongoing investigations. 1 La présente série documente les bases scientifiques des évaluations des ressources halieutiques du Canada. Elle traite des problèmes courants selon les échéanciers dictés. Les documents qu’elle contient ne doivent pas être considérés comme des énoncés définitifs sur les sujets traités, mais plutôt comme des rapports d’étape sur les études en cours.
CARACTERIZAÇÃO MORFOMÉTRICA DA BACIA HIDROGRÁFICA DO RIBEIRÃO SANTO ANTÔNIO - GO

O conhecimento dos aspectos morfometricos de uma bacia hidrografica e indispensavel para o planejamento do uso e ocupacao das terras. O presente trabalho teve como objetivo principal realizar a caracterizacao morfometrica da bacia hidrografica do Ribeirao Santo Antonio – GO, cujo estudo justifica-se devido a grande importância desse ribeirao para a cidade de Ipora e municipios vizinhos, por ser o principal abastecedor de agua. A metodologia de analise deu-se por meio da avaliacao de parâmetros fisicos e morfometricos. Como resultado da pesquisa, destacam-se os valores baixos da Densidade da drenagem (1,30 km²), Relacao do relevo (67,34), entre outros, afirmando ser uma bacia que apresenta suscetibilidade media a enchentes e que necessita de planejamento adequado para utilizacao das terras em atividades antropicas.
Exact asymptotics for fluid queues fed by multiple heavy-tailed on-off flows

• A submitted manuscript is the version of the article upon submission and before peer-review. There can be important differences between the submitted version and the official published version of record. People interested in the research are advised to contact the author for the final version of the publication, or visit the DOI to the publisher's website. • The final author version and the galley proof are versions of the publication after peer review. • The final published version features the final layout of the paper including the volume, issue and page numbers.
CZECH TECHNICAL UNIVERSITY IN PRAGUE Faculty of Nuclear Sciences and Physical Engineering Department of Physics

This thesis is dedicated to the first measurement of the central exclusive production process in proton-proton collisions at RHIC with the STAR detector at √ s = 510 GeV. At this energy, this process is dominated by a Double Pomeron Exchange mechanism. Therefore, it is very promising for the search of gluon bound states, glueballs. The experimental confirmation of their existence would be yet another strong support for the validity of the quantum chromodynamics theory. The diffractively scattered protons, moving intact inside the RHIC beam pipe after the collision, were measured in the Roman Pots system allowing full control of the interaction’s kinematics, and thus verification of the exclusivity. The preliminary results on the invariant mass distributions of centrally exclusively produced π+π−, K+K− and pp̄ pairs measured within the STAR acceptance are presented in this thesis.
Thermal perturbation, mineral assemblages, and rheology variations induced by dyke emplacement in the crust

We constructed a thermomechanical model to examine the changes in rheology caused by the periodic intrusion of basaltic dykes in a two‐layered continental crust. Dyke intrusion can locally change the mineralogical composition of the crust in space and time as a result of temperature‐induced metamorphism. In our models we paid particular attention to determine how different mineral assemblages and reaction kinetics during metamorphism impact on the thermomechanical behavior of the crust, in terms of differential stress values. We investigated several lithologies characteristic for intracontinental crust: (1) a quartz‐feldspathic crust (QF), (2) a crust with a mineralogical assemblage resembling the average chemical composition occurring in literature (CC), and (3) a micaschist crust (MS). Our model shows that temperature profiles are weakly influenced by metamorphism, with negligible variations in the T‐t paths. The results indicate that intrusion‐induced changes in the crustal rheology are strongly dependent on mineralogical assemblage variation. The strength of a dyke aureole in the upper crust increases during dyke emplacement, which may cause migration of later dykes and influence the dyke spacing. In contrast, in the lower crust the strength of a dyke aureole decreases during dyke emplacement. Fast kinetics results in a ductile lower crust in proximity of the dykes, whereas slower kinetics leads to the formation of partial melts and subsequent switch from ductile to brittle behavior. Lithology exerts a dominant role on the quantity of melt produced, with higher volume percentages occurring in the MS case study. Produced melts may migrate and support acidic volcanic activity.
Factors Influencing Career Decision Making in Adolescents and Adults

The structure of the Career Decision-Making Difficulties Questionnaire (CDDQ) was validated and compared across two age cohorts using Structural Equation Modelling. One hundred and twenty-one upper high school students (78 females, 43 males—mean age 15.92 years) participated in Study 1, while 127 adults (86 females, 41 males—mean age 33.44 years) completed the survey for Study 2. The model confirmed the multidimensional structure of the CDDQ, although five first-order factors provided a better fitting model than the three higher-order factors postulated. The model fit both groups, suggesting that a common pattern of difficulties was experienced by people of different ages, although older career deciders reported fewer difficulties on all CDDQ subscales than did students.
Biomass removal and its effect on productivity of an artificially regenerated forest stand in the Missouri ozarks

Intensive harvesting, which removes a greater proportion of the forest biomass than conventional harvesting and the associated nutrients, may cause a decline in forest productivity. Planted seedling response to three biomass removal levels (1. removal of boles only=OM1, 2. all surface organic matter removed, forest floor not removed=OM2, and 3. removal of all surface vegetation plus forest floor = OM3) was examined in one of the Forest Service Long-Term Soil Productivity (LTSP) research studies located in the Missouri Ozarks. Before harvesting, the study area contained a mature upland oak-hickory (Quercus-Carya spp.) forest with some oak-pine (Quercus spp.-Pinus echinata Mill.) communities. Soil nutrient concentrations at one year and eight years later were compared with soil nutrient concentrations in uncut control plots. Survival of red oak, white oak, and shortleaf pine seedlings increased with increasing levels of surface organic matter removal. Mean height for red and white oaks was significantly (p ≤ 0.05) greater for OM1 and OM2 plots than for OM3 plots. Mean diameter at breast height (dbh) was significantly less for OM1 plots than for OM3 plots. Mean height for shortleaf pine was not significantly affected by biomass removal treatments but dbh was. Overall, measurements of tree growth after nine growing seasons and soil and leaf chemistry indicated that site productivity has not been impaired by the removal of surface organic matter.
YOUTH VALUES IN CROATIA

U clanku se analiziraju vrijednosti mladih u Hrvatskoj u socijalistickom i postsocijalistickom razdoblju te uspoređuju s vrijednostima starijih i politicke elite. Komparativna analiza obavljena je na podacima cetiri empirijska istraživanja iz 1986, 1999. i 2004. godine. Rezultati pokazuju da su dominantne vrijednosti mladih ostale stabilne, s blagim oscilacijama u rangovima. Mladi se od starijih razlikuju po svestranijim interesima, vecem prihvacanju postmaterijalistickih i manjem prihvacanju tradicionalnih i politickih vrijednosti. Također je ustanovljeno da je optimizam mladih konstantno na visokoj razini, kao i zadovoljstvo životom, koje je izraženije nego među starijima. U svim ispitivanim segmentima politicka elita se primjetno razlikuje i od mladih i od starijih. Ukupni nalazi potvrđuju da prihvacanje promatranih vrijednosti varira s obzirom na drustveno-politicki kontekst te dob i socijalni status ispitanika. Kako su te varijacije ogranicenog dosega zakljucak je da i ova analiza potvrđuje relativnu stabilnost vrijednosti te da se njihova međugeneracijska transmisija odvija na nacin koji ne ugrožava drustveni kontinuitet.
COST 271 Action - Effects of the upper atmosphere on terrestrial and Earth-space communications: introduction

2) ( 1 ) Istituto Nazionale di Geofisica e Vulcanologia, Roma, Italy ( 2 ) Rutherford Appleton Laboratory, Chilton, Didcot, Oxon, U.K. The COST 271 Action («Effects of the Upper Atmosphere on Terrestrial and Earth-space Communications») within the European ionospheric community has the objectives, embodied in the Memorandum of Understanding (MoU): to study the influence of upper atmospheric conditions on terrestrial and Earth-space communications, to develop methods and techniques to improve ionospheric models over Europe for telecommunication and navigation applications and to transfer the results to the appropriate Radiocommunication Study Groups of the International Telecommunication Union (ITU-R) and other national and international organizations dealing with the modern communication systems. This introductory paper summarises briefly the background and historical context of COST 271 and outlines the main objectives, working methods and structure. It also lists the participating countries and institutions, the Management Committee (MC) Meetings, Workshops and Short-term Scientific Missions. In addition, the paper discusses the dissemination of the results and the collaboration among the participating institutions and researchers, before outlining the content of the Final Report.
ATVB IN FOCUS: Cardiovascular Effects of Anticancer Treatments/Agents

Abnormal expression or function of several classes of kinases contribute to the development of many types of solid and hematologic malignancies. TKs (tyrosine kinases) in particular play a role in tumor growth, metastasis, neovascularization, suppression of immune surveillance, and drug resistance. TKIs (tyrosine kinase inhibitors) targeted to TKs such as BCRABL1, VEGF receptors, PDGF receptors, have transformed therapy of certain forms of cancer by providing excellent efficacy with relatively low adverse event rates. Yet some of these agents have been associated with high rates of vascular events, presumably from prothrombotic complications that result in myocardial infarction, stroke, and critical limb ischemia. This review describes the scope of the problem evidenced by clinical experience with some of the most commonly used TKIs, with a focus on TKIs targeted to the BCR-ABL1 (breakpoint cluster region-Abelson 1) translocation. We also discuss the potential mechanisms responsible for arterial thrombotic complications that could lead to mitigation strategies or unique TK targeting strategies to reduce adverse event rates without compromising efficacy. GRAPHIC ABSTRACT: A graphic abstract is available for this article.
FGF23 is a potential prognostic biomarker in uterine sarcoma

Background: Uterine sarcoma (US) is a highly malignant cancer with poor prognosis and high mortality in women. In this study, we evaluated the expression of human fibroblast growth factor 23 (FGF23) in different US subtypes and the relationship between survival and clinicopathological characteristics. Methods: We conducted a comparative analysis of FGF23 gene expression in different pathological types of US. Utilizing a cohort from The Cancer Genome Atlas (TCGA) of 57 patients, a 50-patient microarray dataset (GSE119043) from the Gene Expression Omnibus (GEO) and a clinical cohort of 44 patients, we analyzed gene expression profiles and corresponding clinicopathological information. Immunohistochemistry (IHC) was used to examine the expression level of FGF23 in four US subtypes. Survival analysis was used to assess the relationship between FGF23 expression and prognosis in US patients. Results: Compared with uterine normal smooth muscle (UNSM) and uterine leiomyoma (ULM), FGF23 expression was significantly upregulated in US and was differentially expressed in four US subtypes. Uterine carcinosarcoma (UCS) exhibited the highest expression of FGF23 among the subtypes. Survival analysis indicated that FGF23 expression was unrelated to overall survival and progression-free survival in US (P>0.05). Similar results were obtained from the validation cohorts. Univariate and multivariate analyses showed no significant correlation between FGF23 expression and the US prognosis. Tumor stage, CA125 and tumor recurrence were independent prognostic factors for survival of US patients. Conclusion: FGF23 was highly expressed in uterine sarcoma and was promising as a novel potential biomarker for the diagnosis and prognosis of uterine sarcoma. Keywords: Human fibroblast growth factor 23, Prognosis, Uterine sarcoma, Biomarker
The impact of Gam-COVID-Vac, an Adv5/Adv26 COVID-19 vaccine, on the biomarkers of endothelial function, coagulation and platelet activation

Background: COVID-19 vaccines have played a critical role in controlling the COVID-19 pandemic. Although generally considered safe, COVID-19 vaccination has been associated with rare but severe thrombotic events, occurring mainly in the context of adenoviral vector vaccines. A better understanding of mechanisms underlying vaccine-induced hypercoagulability and prothrombotic state is needed to improve the vaccine safety profile. Methods: We assessed changes to biomarkers of endothelial function (endothelin, ET-1), coagulation (thrombomodulin, THBD and plasminogen activator inhibitor, PAI) and platelet activation (platelet-activating factor, PAF, and platelet factor 4 IgG antibody, PF4 IgG) within a three-week period after the first (prime) and second (boost) doses of Gam-Covid-Vac, an AdV5/AdV26-vectored COVID-19 vaccine. Blood plasma collected from vaccinees (n=58) was analyzed using ELISA assays. Participants were stratified by prior COVID-19 exposure based on their baseline SARS-CoV-2-specific serology results. Results: We observed a significant post-prime increase in circulating ET-1, with levels sustained after the boost dose compared to baseline. ET-1 elevation following dose-2 was most pronounced in vaccinees without prior COVID-19 exposure. Prior COVID-19 was also associated with a mild increase in PAI post-prime dose. Conclusions: Vaccination was associated with elevated ET-1 up to day 21 after the second vaccine dose, while no marked alterations to other biomarkers, including PF4 IgG, were seen. These findings suggest that a role of persistent endothelial activation following COVID-19 vaccination warrants further investigation.
Reações fisiológicas de caprinos das raças Anglo-Nubiana e Saanen mantidos à sombra, ao sol e em ambiente parcialmente sombreado

The experiment was carried out to measure effects of thermal stress on the rectal temperature (RT) and respiratory frequency (RF), in animals of Anglo-nubian and Saanen breeds, raised in a tropical humid climate. The goats were divided into three groups, each group consisting of four females from each breed group. Each group was submited to three experimental treatment: treatment A, with a sun protected enclosed area; treatment B, a sun exposed area without covering; and treatment C, area with 50% covered section and 50% sun exposed area, which permitted free circulation of the goats. A Balanced Latin Square design was used. The RT and RF of the goats, in the afternoon periods (l4h00), were higher, than in the morning periods (08h00). The animals kept in the sun presented much higher results, especially in the afternoon periods, than the animals in the other two areas. There were no differences in the RT and RF between groups maintained in the shade or in partially covered area but there were differences in the RT and RF measurements between the two breeds, in the morning periods and in the afternoon periods. Independently of treatment and daily (morning and afternoon) surrounding temperature variation, the average of RT and RF in the Anglo-nubian goats were lower than the Saanen goats, which showed to be more sensitive to thermic stress.
Livelihood features of small scale fishing communities : A case from Singkarak Lake, west Sumatra Indonesia

While millions of poor still depend on small scale freshwater fisheries to earn a meager leaving, the sector shows overall decline in catches over recent years throughout South East Asia. Among few other causes, overfishing is often pointed out as a main issue. Little research is done regarding the socio-economic and technical diversity among the fishing communities, being both the victims of the problem and its possible cause. This research aims to characterize fishing communities in Singkarak Lake (West Sumatra, Indonesia) by exploring their socio-economic and fishing characteristics and also identifying the problems, constraints confronted by those communities as the entry point for policy formulation in an effort to support small-scale fishermen and to address fisheries related problem appropriately. Results show that fishing communities in Singkarak Lake have high level of homogeneity in terms of their fishing activities which represents the highest in cash households' income, but extreme diversity in portfolio of livelihood activities. Combination of fishing and farming widely practiced by fishers in addition to other income supplements either seasonal or permanent. Income generating activities employed by the fishers become more diverse in conjunction to the decrease of fish production and some other factors such as degraded environmental condition, construction of Hydro Electric Power Plant (HEPP) and fishing practiced itself. Fishing labor productivity is found to be lower than construction works and nearly same as farming labor productivity. However, fishers keep fishing because it can secure their daily food needs. The choice of diversification strategies is also based on the assets owned by the households and on higher labor productivity offered by alternative activities out of fishing. (Resume d'auteur)
Perceptions, maltreatment and religion as predictors of the psycho-emotional impact on nurses during the COVID-19 pandemic

ABSTRACT Objectives: to analyze the relationship between perceptions, abuse and religion with the psycho-emotional impact on nurses during the COVID-19 pandemic. Methods: descriptive-analytical cross-sectional study. It took place between 2020 and 2021 and a total of 319 clinical nurses in Peru were interviewed using the DASS-21. Associations were assessed using Spearman’s Rho and multiple regression. Results: 18.5% had some degree of stress; 50.2%, anxiety and 29.1%, depression. Experience of abuse, self-perception of mental health and religion were predictors of stress, anxiety and depression. The length of work experience predicts stress and anxiety. In addition, self-perception of information and gender were predictors of depression. Conclusions: peruvian nurses have high levels of stress, anxiety and depression, and this psycho-emotional impact was associated with perceptions, experiences of abuse and religion.
Stay Rates of Foreign Doctorate Recipients from U.S. Universities, 1997

Highlights This study estimated the proportion of foreign recipients of science and engineering (S/E) doctorates from U.S. universities who stayed in the United States after graduation. The primary data used to estimate stay rates were special data tabulations obtained from the Social Security Administration on the proportion of persons in various groups that paid social security taxes. The 53 percent overall stay rate for 1992-1993 doctorates varies by discipline from 32 percent for social sciences/psychology to 62 percent for the physical sciences. Life sciences and engineering stay rates were 54 percent. Within life sciences, the stay rate ranges from agriculture with 30 percent temporary residents staying in the United States; to biochemistry and the other biological sciences where the stay rate was over 60 percent. Stay rates vary dramatically by country of citizenship at the time of the S/E doctorate award. China and India have the highest stay rates; Korea and Brazil the lowest. The variation is so great that doctorate recipients from China are staying in the United States at 10 times the rate of those from Korea. There was a substantial increase in the stay rate of foreign doctorate recipients from U.S. universities in the decade leading up to the 1997 estimates reported here. There was also a substantial increase in doctorate degrees awarded to non-U.S. citizens prior to the mid-1990s. With both the number of degrees and the stay rate increasing, this led to very dramatic increases in the number of foreign doctorate students staying to join the U.S. workforce in the early 1990s. Stay rates of a given cohort are quite stable over time. Temporary residents receiving S/E doctorates in 1987 had a stay rate of 45 percent after 5 years, declining only to 44 percent after 10 years. However, this stability in the total rate masks some movement back and forth between foreign nations and the United States. About 8 percent of those from the 1987 cohort who were here after 10 years were not in the United States after 5 years. An increasing number of foreign students are permanent residents by the time they receive a doctorate in an S/E field. The stay rate for permanent resident doctorate recipients from U.S. universities in 1992-1993 was 78 percent in 1997. As with temporary residents, the stay rate for those with social science doctorates is below this average, and the rate for engineering and physical sciences …