Miracle-dz/UniFAR-FTUs huggingface dataset:
Sensory Analysis of Pliek U Using the Analytical Hierarchy Process (AHP) Method

The people of Aceh usually use coconut flesh to produce three derivative products, namely Pliek u oil, Simplah oil, and Pliek u oil. Pliek u is made from coconut flesh (Cocos nucifera L.) that has been fermented, dried, and oil-extracted without the addition of microbes. It has developed into a traditional recipe for cooking spices, chili sauce, and salad. Therefore, this study aims to perform sensory analysis on various forms of Pliek u based on its thickness and fermentation time using the Analytical Hierarchy Process (AHP). The product was assessed for certain sensory parameters, such as color, aroma, and taste. According to the preference of the panelists for product acceptance, the sensory criteria with the highest priority weight were taste, aroma, and color at 0.550, 0.230, and 0.219, respectively. The result showed that the highest alternative weight was observed in the Pliek u with a thickness of 30 cm and a fermentation time of 7 days (K3F2) at 0.212, while a thickness of 10 cm and a fermentation time of 3 days (K1F1) were obtained the lowest alternative weight of 0.042. Also, the overall consistency value of Pliek u sensory taste was 0.02, which was acceptable since it was less than the pairwise consistency level of 0.1. According to the descriptive test, the best result was obtained by processing Pliek u at a thickness of 30 cm and a fermentation time of 7 days (K3F2), with a light brown color, no rancid odor, and a slightly sour taste.
The partition of unity finite element method

Abstract : A new finite element method is presented that features the ability to include in the finite element space knowledge about the partial differential equation being solved. This new method can therefore be more efficient than the usual finite element methods. An additional feature of the partition-of-unity finite element method is that finite element spaces of any desired regularity can be constructed very easily. Moreover the method is of "meshless" type. This paper includes a convergence proof of this method and illustrates its efficiency by an application to the Helmholtz equation for high wave numbers. The basic estimates for a-posteriori error estimation for this new method are also proved. (AN)
Intelligent Reflecting Surface-Assisted Low-Latency Federated Learning Over Wireless Networks

Federated learning (FL) is an emerging technique to support privacy-aware and resource-constrained machine learning, where a base station (BS) will coordinate a set of distributed Internet of Things (IoT) devices to train a shared machine learning model with their local data sets. Nevertheless, due to the frequent interactions between BS and distributed IoT devices for the aggregating/distributing learning model parameters, the performance of FL is fundamentally restricted by the randomness of channel condition. To address this issue, we utilize the intelligent reflecting surface (IRS) to improve the efficiency of learning model aggregation/distribution. In addition, we consider two transmission protocols to enable the model aggregation from IoT devices to BS, i.e., frequency division multiple access (FDMA) and nonorthogonal multiple access (NOMA). For both protocols, we formulate the total training latency minimization problem under the available energy constraints of IoT devices, to jointly optimize the phase shifts of IRS, communication resource scheduling, and transmit power and local computing frequencies of IoT devices. Moreover, we further develop the efficient multidimensional resource management algorithms to solve the formulated training latency minimization problems. Numerical results demonstrate that the proposed IRS-assisted FL systems can achieve significant latency reduction as compared with other benchmark methods, and the NOMA-based model aggregation method exhibits a lower total training latency than the FDMA-based counterpart.
Do grateful employees take charge more in China? A joint moderating effect model

ABSTRACT Taking charge plays a vital role in the survival and development of an organization, but the inherent voluntary and risky characteristics of this action may prevent employees from engaging in this proactive work behaviour. To identify employees who are willing to take charge and to understand why they do so, this research focuses on the influence of trait gratitude on taking charge while incorporating a joint moderator that combines supervisor-subordinate guanxi and role breadth self-efficacy. Data concerning 255 employees working in Jiangsu Province in China were analysed, and the results show that gratitude is positively related to taking charge and that this relationship is jointly moderated by supervisor-subordinate guanxi and role breadth self-efficacy. In other words, the relationship between gratitude and taking charge is stronger among employees who exhibit strong guanxi with supervisors and exhibit high role breadth self-efficacy. Theoretical and practical implications are discussed.
The Genetic Basis of Gene Expression Divergence in Antennae of Two Closely Related Moth Species, Helicoverpa armigera and Helicoverpa assulta

The closely related species Helicoverpa armigera (H. armigera) and Helicoverpa assulta (H. assulta) have different host plant ranges and share two principal components of sex pheromones but with reversed ratios. The antennae are the main olfactory organ of insects and play a crucial role in host plant selection and mate seeking. However, the genetic basis for gene expression divergence in the antennae of the two species is unclear. We performed an allele-specific expression (ASE) analysis in the antennal transcriptomes of the two species and their F1 hybrids, examining the connection between gene expression divergence and phenotypic differences. The results show that the proportion of genes classified as all cis was higher than that of all trans in males and reversed in females. The contribution of regulatory patterns to gene expression divergence in males was less than that in females, which explained the functional differentiation of male and female antennae. Among the five groups of F1 hybrids, the fertile males from the cross of H. armigera female and H. assulta male had the lowest proportion of misexpressed genes, and the inferred regulatory patterns were more accurate. By using this group of F1 hybrids, we discovered that cis-related regulations play a crucial role in gene expression divergence of sex pheromone perception-related proteins. These results are helpful for understanding how specific changes in the gene expression of olfactory-related genes can contribute to rapid evolutionary changes in important olfactory traits in closely related moths.
Dilute Silver Diamine Fluoride (1:10) Versus Light Cure Calcium Hydroxide as Indirect Pulp Capping Agents in Primary Molars - A Randomized Clinical Trial.

AIM To evaluate the clinical and radiographic outcomes of diluted silver diamine fluoride (1:10) and light cure calcium hydroxide as indirect pulp capping agents in primary molars. STUDY DESIGN Fifty-six primary molars requiring indirect pulp treatment were randomly allocated to two groups: Dilute SDF (one drop of SDF mixed with 9 drops of distilled water giving a 1:10 dilution) and light cure calcium hydroxide. The indirect pulp treatment was followed by glass ionomer cement restoration and all primary molars received stainless steel crown as full coverage restoration. The teeth were followed up both clinically and radiographically at 1,6- and 12-months' time interval using a pre-determined criterion. The results were statistically analyzed using Chi square analysis. The significance level was set at p ≤0.05. RESULTS Overall clinical and radiographic success rate of indirect pulp treatment with SDF was 96% and with light cure calcium hydroxide was 91.6% respectively at the end of 12 months but the difference was not statistically significant (p>0.05). CONCLUSION Dilute silver diamine fluoride (1:10) can be advocated as potential indirect pulp capping agent in primary molars with deep carious lesions.
Pharmacological Inhibition of S100A4 Attenuates Fibroblast Activation and Renal Fibrosis

The TGF-β/Smad3 signaling pathway is an important process in the pathogenesis of kidney fibrosis. However, the molecular mechanisms are not completely elucidated. The current study examined the functional role of S100A4 in regulating TGF-β/Smad3 signaling in fibroblast activation and kidney fibrosis development. S100A4 was upregulated in the kidney in a murine model of renal fibrosis induced by folic acid nephropathy. Further, S100A4 was predominant in the tubulointerstitial cells of the kidney. Pharmacological inhibition of S100A4 with niclosamide significantly attenuated fibroblast activation, decreased collagen content, and reduced extracellular matrix protein expression in folic acid nephropathy. Overexpression of S100A4 in cultured renal fibroblasts significantly facilitated TGF-β1-induced activation of fibroblasts by increasing the expression of α-SMA, collagen-1 and fibronectin. In contrast, S100A4 knockdown prevented TGF-β1-induced activation of fibroblast and transcriptional activity of Smad3. Mechanistically, S100A4 interacts with Smad3 to stabilize the Smad3/Smad4 complex and promotes their translocation to the nucleus. In conclusion, S100A4 facilitates TGF-β signaling via interaction with Smad3 and promotes kidney fibrosis development. Manipulating S100A4 may provide a beneficial therapeutic strategy for chronic kidney disease.
Average Case Analysis of Algorithms on Sequences

From the Publisher: While most algorithm designs are finalized toward worst case scenarios where they have to cope efficiently with unrealistic inputs, the average case solution is a probabilistic approach that allows for the possibility that a simple algorithm would suffice. This book provides a unique overview of the tools and techniques used in average case analysis of algorithms.
Memory-Enhancing Effect of 8-Week Consumption of the Quercetin-Enriched Culinary Herbs-Derived Functional Ingredients: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

Due to great demand for memory enhancers, the memory-enhancing effects and the possible underlying mechanisms of the functional ingredients derived from the combined extract of Polygonum odoratum and Morus alba were investigated. A total of 45 participants randomly received either a placebo or the developed herbal supplement at a dose of 50 or 1500 mg/day. The consumption was done once daily for 8 weeks. Working memory was assessed via both an event-related potential and computerized battery tests at baseline and at the end of the 8-week study period. Acetylcholinesterase (AChE) and monoamine oxidase type A and type B (MAO-A, MAO-B) levels were also measured at the end of the study. The subjects who consumed the supplement containing a developed functional ingredient at a dose of 1500 mg/day showed reduced latencies but increased amplitudes of N100 and P300. An improvement in working memory and the suppression of AChE, MAO-A, and MAO-B activities were also observed. Therefore, this study clearly demonstrates the cognitive enhancing effect of the developed herbal congee, which may be associated with the suppressions of AChE and both types of MAO.
Optimization of the X ( 3872 ) → J / ψπ + π − selection at LHCb Annabelle

3 Optimized selection 8 3.1 Manual independent cuts . 8 3.1. 1 Settings . 8 3.1. 2 Results . 8 3.1. 3 Application . 9 3.2 Fisher discriminant method for optimization . 11 3.2. 1 Theory . 11 3.2. 2 Settings . 12 3.2. 3 Application . 17 3.3 Rectangular cuts with TMVA . 19 3.3.1 Operational principles . 19 3.3.2 Results . 19 3.3.3 Application . 20
Downward Wage Rigidity and Recession Dynamics in Advanced and Emerging Economies

Downward wage rigidity limits the downward adjustment of wages, especially during recessions. Although macroeconomic models generally suggest that wage rigidity exacerbates employment losses and generates asymmetric business cycles, direct empirical evidence for this effect is scarce. In this paper, we construct a data set covering 53 countries, including both emerging markets and advanced economies, to measure and compare downward wage rigidities across countries. We find that wage rigidities are widespread, but higher in emerging markets overall. In addition, we provide empirical evidence that countries with higher downward wage rigidities are subject to more sizable contractions in employment and real GDP per capita during recessions. We also explore possible determinants of downward wage rigidity and show that our measure is tied to minimum wage growth and de jure labor market rigidity.
The next generation of sinus stents for chronic rhinosinusitis: A systematic review

Characterized by impaired mucociliary clearance with subsequent compromised microbial elimination, chronic rhinosinusitis (CRS) is known as a multifactorial disease process in which bacterial infection or colonization could play a role in the initiation or propagation of the inflammatory response. Various non-systemic, topical therapies have recently emerged as an alternative to conventional oral regimens in managing CRS. A topical sinonasal drug delivery system using a bioabsorbable stent represents one of the most attractive methods among multiple topical delivery options. This review discusses the commercially available topical drug delivery platform (sinus stents) for CRS and its shortcomings. Based on the current drawbacks of sinus stents, this article has also highlighted the future developmental perspectives to create the next generation of a sinus stent, thereby harnessing the full potential of the sinus stent as efficient topical drug delivery for recalcitrant CRS.
Plasmons and the spectral function of graphene

We report a theoretical study of the influence of electron-electron interactions on the one-particle Green's function of a doped graphene sheet based on the random-phase approximation and on graphene's massless Dirac equation continuum model. We find that states near the Dirac point interact strongly with plasmons with a characteristic frequency ${\ensuremath{\omega}}_{\mathrm{pl}}^{\ensuremath{\star}}$ that scales with the sheet's Fermi energy and depends on its interaction coupling constant ${\ensuremath{\alpha}}_{\mathrm{gr}}$, partially explaining prominent features of recent angle-resolved photoemission spectroscopy data.
Loss to Follow-Up Risk among HIV Patients on ART in Zimbabwe, 2009–2016: Hierarchical Bayesian Spatio-Temporal Modeling

Loss to follow-up (LTFU) is a risk factor for poor outcomes in HIV patients. The spatio-temporal risk of LTFU is useful to identify hotspots and guide policy. Secondary data on adult HIV patients attending a clinic in provinces of Zimbabwe between 2009 and 2016 were used to estimate the LTFU risk in each of the 10 provinces. A hierarchical Bayesian spatio-temporal Poisson regression model was fitted using the Integrated Nested Laplace Approximation (INLA) package with LTFU as counts adjusting for age, gender, WHO clinical stage, tuberculosis coinfection and duration on ART. The structured random effects were modelled using the conditional autoregression technique and the temporal random effects were modelled using first-order random walk Gaussian priors. The overall rate of LTFU was 22.7% (95%CI: 22.6/22.8) with Harare (50.28%) and Bulawayo (31.11%) having the highest rates. A one-year increase in the average number of years on ART reduced the risk of LTFU by 35% (relative risk (RR) = 0.651; 95%CI: 0.592–0.712). In general, the provinces with the highest exceedance LTFU risk were Matabeleland South and Matabeleland North. LTFU is one of the drawbacks of HIV prevention. Interventions targeting high-risk regions in the southern and northern regions of Zimbabwe are a priority. Community-based interventions and programmes which mitigate LTFU risk remain essential in the global HIV prevention campaign.
“We’re Lucky to Have Doctors at All”; A Qualitative Exploration of Australian Farmers’ Barriers and Facilitators to Health-Related Help-Seeking

This study aimed to explore barriers and facilitators that impact on farmers’ help-seeking behaviours for health and mental health concerns. Fifteen semi-structured interviews were conducted with farmers (12 male; age 51.7 ± 12.6 years) from three rural regions in South Australia. Interviews explored demographic and farm-related characteristics, perceptions of individual (and where relevant family) health and mental health concerns and experiences, and perceived barriers of health support-seeking. Thematic analysis was used to identify key themes. Four key themes were identified relating to help-seeking; personal attitudes and beliefs, farm-related barriers, health system barriers and the provision of support from family and friends. Dominant personal attitudes included valuing independence, strength and privacy. Farm related barriers included the ‘farm comes first’ and the fact that ‘farm work is never done’. Health system barriers included issues relating to availability of choice and access, professionals (lack of) understanding of farm life, and time and financial costs of accessing care. Provision of support from family and friends involved informal help and advice, including facilitating access to professional support. Multiple attitudinal, structural, and farm-related issues affect farmers’ help-seeking. Professionals who understand farm work practices and routines are valued by farmers and this is likely to facilitate access to care. Workforce development programs and community programs that involve farmers’ perspectives as consumers and co-designers, using evidence-based strategies, may assist in strengthening these relationships.
NADPH Oxidase Mediates Oxidative Stress and Ventricular Remodeling through SIRT3/FOXO3a Pathway in Diabetic Mice

Oxidative stress and mitochondrial dysfunction are important mechanisms of ventricular remodeling, predisposed to the development of diabetic cardiomyopathy (DCM) in type 2 diabetes mellitus. In this study, we have successfully established a model of type 2 diabetes using a high-fat diet (HFD) in combination with streptozotocin (STZ). The mice were divided into three groups of six at random: control, diabetes, and diabetes with apocynin and the H9c2 cell line was used as an in vitro model for investigation. We examined the molecular mechanisms of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activation on mitochondrial dysfunction and ventricular remodeling in the diabetic mouse model. Hyperglycemia-induced oxidative stress led to a reduced expression of sirtuin 3 (SIRT3), thereby promoting forkhead box class O 3a (FOXO3a) acetylation in ventricular tissue and H9c2 cells. Reactive oxygen species (ROS) overproduction promoted ventricular structural modeling and conduction defects. These alterations were mitigated by inhibiting NADPH oxidase with the pharmaceutical drug apocynin (APO). Apocynin improved SIRT3 and Mn-SOD expression in H9c2 cells transfected with SIRT3 siRNA. In our diabetic mouse model, apocynin improved myocardial mitochondrial function and ROS overproduction through the recovery of the SIRT3/FOXO3a pathway, thereby reducing ventricular remodeling and the incidence of DCM.
Potential Roles of Teamwork and Unmet Needs on Surgical Learning Curves of Spinal Robotic Screw Placement

Background The aim of this study was to investigate the learning curve of robotic spine surgery quantitatively with the well-described power law of practice. Methods Kaohsiung Medical University Hospital set up a robotic spine surgery team by the neurosurgery department in 2013 and the orthopedic department joined the well-established team in 2014. A total of consecutive 150 cases received robotic assisted spinal surgery. The 150 cases, with 841 transpedicular screws were enrolled into 3 groups: the first 50 cases performed by neurosurgeons, the first 50 cases by orthopedic surgeons, and 50 cases by neurosurgeons after the orthopedic surgeons joined the team. The time per screw and accuracy by each group and individual surgeon were analyzed. Results The time per screw for each group was 9.56 ± 4.19, 7.29 ± 3.64, and 8.74 ± 5.77 minutes, respectively, with p-value 0.0017. The accuracy was 99.6% (253/254), 99.5% (361/363), and 99.1% (222/224), respectively, with p-value 0.77. Though the first group took time significantly more on per screw placement but without significance on the nonlinear parallelism F-test. Analysis of 5 surgeons and their first 10 cases of short segment surgery showed the time per screw by each surgeon was 12.28 ± 5.21, 6.38 ± 1.54, 8.68 ± 3.10, 6.33 ± 1.90, and 6.73 ± 1.81 minutes. The first surgeon who initiated the robotic spine surgery took significantly more time per screw, and the nonlinear parallelism test also revealed only the first surgeon had a steeper learning curve. Conclusion This is the first study to demonstrate that differences of learning curves between individual surgeons and teams. The roles of teamwork and the unmet needs due to lack of active perception are discussed.
Dichrocephala integrifolia Aqueous Extract Antagonises Chronic and Binges Ethanol Feeding-Induced Memory Dysfunctions: Insights into Antioxidant and Anti-Inflammatory Mechanisms

Ethanol consumption is widely accepted despite its addictive properties and its mind-altering effects. This study aimed to assess the effects of Dichrocephala integrifolia against, memory impairment, on a mouse model of chronic and binges ethanol feeding. Mice were divided, into groups of 8 animals each, and received distilled water, Dichrocephala integrifolia aqueous extract (25; 50; 100; or 200 mg/kg) or memantine (200 mg/kg) once a day, while fe, with Lieber-DeCarli control (sham group only) or Lieber-DeCarli ethanol diet ad libitum for 28 days. The Y maze and the novel object recognition (NOR) tests were used to evaluate spatial short-term and recognition memory, respectively. Malondialdehyde, nitric oxide, glutathione levels, and proinflammatory cytokines (Il-1β, TNF-α, and Il-6) were evaluated in brain homogenates following behavioral assessments. The results showed that chronic ethanol administration in mice was associated with a significant (p < 0.001) reduction in the spontaneous alternation percentage and the discrimination index, in the Y maze and the NOR tests, respectively. It significantly (p < 0.01) increased oxidative stress and inflammation markers levels in the brain. Dichrocephala integrifolia (100 and 200 mg/kg) as well as memantine (200 mg/kg) significantly (p < 0.001) increased the percentage of spontaneous alternation and the discrimination index, in the Y maze and NOR tests, respectively. Dichrocephala integrifolia (100 and 200 mg/kg) likewise memantine (200 mg/kg) significantly (p < 0.01) alleviated ethanol-induced increase, in the brain malondialdehyde level, nitric oxide, Il-1β, TNF-α, and Il-6. From these findings, it can be concluded that Dichrocephala integrifolia counteracted memory impairment, oxidative stress, and neuroinflammation induced by chronic ethanol consumption in mice.