Miracle-dz/UniFAR-FTUs huggingface dataset:
Home-Based Telework and Presenteeism Across Europe

Objective: Flexible work arrangements such as telework are gaining importance. Although telework is accompanied by advantages for employees such as increased flexibility, current research reveals associations between home-based telework and self-endangering behavior such as sickness presenteeism. As empirical evidence is still scarce, we explore the relationship between home-based telework and sickness presenteeism across Europe. Methods: We perform multilevel analyses including 25,465 individuals who responded to the 6th wave of the European Working Conditions Survey 2015. Results: Home-based telework is positively related to sickness presenteeism. The results are quite robust across different measures of sickness presenteeism and to several sensitivity analyses. Conclusion: Although sickness presenteeism can be functional for specific illnesses, organizations should be aware of possible risks related to home-based telework. They should design telework in a way that it reduces triggers for self-endangering behavior.
EH domain binding protein 1-like 1 (EHBP1L1), a protein with calponin homology domain, is expressed in the rat testis

Summary In this paper, with the aim to find new genes involved in mammalian spermatogenesis, we isolated, for the first time in the rat testis, a partial cDNA clone that encoded EH domain binding protein 1-like 1 (Ehbp1l1), a protein that has a single calponin homology domain (CH). Bioinformatic analysis showed that EHBP1l1 contains three domains: the N-terminal C2-like, the CH and the C-terminal bivalent Mical/EHBP Rab binding (bMERB) domains, which are evolutionarily conserved in vertebrates. We found that Ehbp1l1 mRNA was expressed in several rat tissues, including the liver, intestine, kidney and also in the testis during its development, with a higher level in testis from 12-month-old animals. Interestingly, in situ hybridization experiments revealed that Ehbp1l1 is specifically expressed by types I and II spermatocytes, this result was validated by RT-PCR performed on total RNA obtained from enriched fractions of different testicular cell types. As EHBP1l1 has been described as linked to vesicular transport to the actin cytoskeleton and as an effector of the small GTPase Rab8, we hypothesized that it could participate both in cytoskeletal remodelling and in the regulation of vesicle sorting from the trans-Golgi network to the apical plasma membrane. Our findings provide a better understand of the molecular mechanisms of the differentiation process of spermatogenesis; Ehbp1l1 may also be used as a new marker of testicular activity.
Chemotherapy Treatment Modifications During the COVID-19 Outbreak at a Community Cancer Center in New York City

PURPOSE As a result of their immunocompromised status associated with disease and treatment, patients with cancer face a profound threat for higher rates of complications and mortality if they contract the coronavirus disease 2019 infection. Medical oncology communities have developed treatment modifications to balance the risk of contracting the virus with the benefit of improving cancer-related outcomes. METHODS We systemically examined our community cancer center database to display patterns of change and to unveil factors that have been considered with each decision. We studied a cohort of 282 patients receiving treatment and found that 159 patients (56.4%) had treatment modifications. RESULTS The incidence of treatment modification was observed in patients undergoing adjuvant and neoadjuvant (41.4%), palliative (62.9%), or injectable endocrine or bone-modulating only (76.0%) treatments. Modifications were applied to regimens with myelosuppressive (56.5%), immunosuppressive (69.2%), and immunomodulating (61.5%) potentials. These modifications also affected intravenous (54.9%) and subcutaneous injectable treatments (62.5%) more than oral treatments (15.8%). Treatment modifications in 112 patients (70.4%) were recommended by providers, and 47 (29.6%) were initiated by patients. The most common strategy of modification was to skip or postpone a scheduled treatment (49%). Among treatment with no modifications, treatment regimens were maintained in patients who tolerated treatment well (37.0%), in treatments with curative intent (22%), and in symptomatic patients who required treatment (14%). CONCLUSION Our observation and analysis suggested that the primary goal of treatment modification was to decrease potential exposure. The pattern also reflected the negative impact of the pandemic on health care providers who initiated these changes. Providers have to consider individualized recommendations incorporating multiple factors, such as tolerance, potential toxicity, treatment nature and route, and disease severity.
The untimely demise of the TB Free block model in the wake of coronavirus disease 2019 in India

would achieve (TB) by 2025, 5 years ahead of the global targets, which 1 Nonethe-less, this gave an impetus to all sectors to escalate their efforts towards TB control. a unique public–private partnership model by a tertiary hospital by corporate social responsibility (CSR) funds of the hospital. The aim of this project was to develop a model of care to render a block TB free. The block is a contained unit with a few hundred thousand peo-ple, more amenable to an intervention to demonstrate robust methodology and impact and as a proof of concept rather than a district, which can be too large, heterogeneous and unwieldy. In this study, simultaneous house-to-house active case ﬁnding (ACF) and point-of-care (POC) mobile diagnostic services (digi-tal chest X-ray [CXR] and cartridge-based nucleic acid ampliﬁca-tion
Omics Application in Animal Science—A Special Emphasis on Stress Response and Damaging Behaviour in Pigs

Increasing stress resilience of livestock is important for ethical and profitable meat and dairy production. Susceptibility to stress can entail damaging behaviours, a common problem in pig production. Breeding animals with increased stress resilience is difficult for various reasons. First, studies on neuroendocrine and behavioural stress responses in farm animals are scarce, as it is difficult to record adequate phenotypes under field conditions. Second, damaging behaviours and stress susceptibility are complex traits, and their biology is not yet well understood. Dissecting complex traits into biologically better defined, heritable and easily measurable proxy traits and developing biomarkers will facilitate recording these traits in large numbers. High-throughput molecular technologies (“omics”) study the entirety of molecules and their interactions in a single analysis step. They can help to decipher the contributions of different physiological systems and identify candidate molecules that are representative of different physiological pathways. Here, we provide a general overview of different omics approaches and we give examples of how these techniques could be applied to discover biomarkers. We discuss the genetic dissection of the stress response by different omics techniques and we provide examples and outline potential applications of omics tools to understand and prevent outbreaks of damaging behaviours.
Boron-Doped Reduced Graphene Oxide with Tunable Bandgap and Enhanced Surface Plasmon Resonance

Graphene and its hybrids are being employed as potential materials in light-sensing devices due to their high optical and electronic properties. However, the absence of a bandgap in graphene limits the realization of devices with high performance. In this work, a boron-doped reduced graphene oxide (B-rGO) is proposed to overcome the above problems. Boron doping enhances the conductivity of graphene oxide and creates several defect sites during the reduction process, which can play a vital role in achieving high-sensing performance of light-sensing devices. Initially, the B-rGO is synthesized using a modified microwave-assisted hydrothermal method and later analyzed using standard FESEM, FTIR, XPS, Raman, and XRD techniques. The content of boron in doped rGO was found to be 6.51 at. %. The B-rGO showed a tunable optical bandgap from 2.91 to 3.05 eV in the visible spectrum with an electrical conductivity of 0.816 S/cm. The optical constants obtained from UV-Vis absorption spectra suggested an enhanced surface plasmon resonance (SPR) response for B-rGO in the theoretical study, which was further verified by experimental investigations. The B-rGO with tunable bandgap and enhanced SPR could open up the solution for future high-performance optoelectronic and sensing applications.
Subclinical inflammation and adipose tissue lymphocytes in pregnant females with gestational diabetes mellitus.

CONTEXT Gestational diabetes mellitus (GDM) is accompanied by subclinical inflammation; however, little is known about local inflammation in adipose tissue and placenta. OBJECTIVE To analyse systemic and local subclinical inflammation and adipose tissue lymphocyte content and phenotype in pregnant females with and without GDM. DESIGN Observational study. SETTINGS Academic hospital. PATIENTS Twenty-one pregnant females with GDM (GDM group), 16 pregnant women without GDM (non-GDM group) and 15 non-pregnant control females (N group). INTERVENTIONS Serum samples taken at 28-32 (V1) and 36-38 (V2) gestational week and 6-12 months after delivery (V3) in GDM and non-GDM group and before elective gynaecological surgery in N group. Subcutaneous (SAT) and visceral adipose tissue (VAT) obtained during Caesarean delivery or surgery. MAIN OUTCOME MEASURES Serum levels and adipose tissue expression of proinflammatory cytokines, adipose tissue lymphocyte content and phenotype (for a subset of GDM and non-GDM subjects). RESULTS Accented proinflammatory state in GDM was documented by increased circulating TNF-α levels. In both groups of pregnant females total lymphocytes were higher in VAT compared to SAT. In GDM subjects B and NKT cells were higher in SAT compared to VAT and Th cells were increased relative to SAT of non-GDM group, while no intercompartmental adipose tissue differences were seen in non-GDM females. CONCLUSIONS Pregnant females had higher total lymphocyte count in VAT relative to SAT regardless of GDM. In addition to increased systemic subclinical inflammation, GDM was associated with significant differences in lymphocyte composition between subcutaneous and visceral adipose tissue depots.
Implementing Mental Health Promotion Initiatives—Process Evaluation of the ABCs of Mental Health in Denmark

Treatment and prevention alone are unlikely to make a significant difference in reducing the burden of poor mental health and mental illness. Therefore, mental health promotion (MHP) initiatives are advocated. In 2014, the ABCs of mental health (ABCs) partnership was established in Denmark; in the partnership, partner organisations, e.g., municipalities and NGOs, use a research-based framework for MHP, the ABC-framework, to develop and implement MHP initiatives. This paper has two aims: (1) to outline the overall characteristics of these MHP initiatives; and (2) to explore local coordinator and stakeholder perceptions of the implementation processes and the impact of the MHP initiatives. Questionnaire surveys, individual interviews and group interviews were conducted during 2017–2020. The MHP initiatives were grouped according to three strategies: building MHP capacity, campaign activities to promote mental health awareness and knowledge and establishing and promoting opportunities to engage in mentally healthy activities. The ABC-framework was positively received and viewed as providing relevant knowledge for working with MHP as well as fostering intersectoral and interprofessional collaborations. However, using a bottom-up approach to develop and implement MHP initiatives can be time-consuming and resource demanding, and it requires a deliberate balancing of local adaptability and concrete guidance when engaging stakeholders and implementers. Overall, using the ABC-framework to develop and implement MHP initiatives holds great promise for advancing and promoting MHP practice.
Meta-analysis Comparing Celecoxib with Diclofenac Sodium in Patients with Knee Osteoarthritis

Abstract Objective To compare the efficacy and safety of celecoxib and diclofenac sodium in patients with knee osteoarthritis (KOA). Methods Clinical controlled trials (CCTs) and randomized controlled trials (RCTs) from online databases comparing the efficacy of celecoxib and diclofenac sodium in the treatment of KOA were retrieved. The main outcomes included the treatment effect, C-reactive protein (CRP) level, erythrocyte sedimentation rate (ESR), visual analog scale (VAS) score, and complication rate. The Cochrane risk of bias (ROB) tool in Review Manager 5.3. 5 was used to assess methodological quality. Results Twelve studies (N = 2,350) were included in this meta-analysis. The meta-analysis indicated that celecoxib reduced pain more effectively than diclofenac sodium in patients with KOA, as evaluated by the VAS score. In addition, celecoxib has certain advantages in terms of better treatment effects and greater reductions in the ESR, CRP level, and complication rate. Conclusions Celecoxib is superior to diclofenac sodium in the treatment of KOA. However, well-designed and high-quality RCTs are still needed.
The effect of an ultrasound‐activated needle tip tracker needle on the performance of sciatic nerve block on a soft embalmed Thiel cadaver

In this study, we measured the performance of medical students and anaesthetists using a new tracker needle during simulated sciatic nerve block on soft embalmed cadavers. The tracker needle incorporates a piezo element near its tip that generates an electrical signal in response to insonation. A circle, superimposed on the ultrasound image surrounding the needle tip, changes size and colour according to the position of the piezo element within the ultrasound beam. Our primary objective was to compare sciatic block performance with the tracker switched on and off. Our secondary objectives were to record psychometrics, procedure efficiency, participant self‐regulation and focused attention using eye‐tracking technology. Our primary outcome measures were the number of steps successfully performed and the number of errors committed during each block. Videos were scored by trained experts using validated checklists. Sequential tracker activation and deactivation was randomised equally within subjects. With needle activation, steps improved in 10 (25%) subjects and errors reduced in six (15%) subjects. The most important steps were: needle tip identification before injection, OR (95%CI) 2.12 (1.61–2.80; p < 0.001); and needle tip identification before advance of the needle, 1.80 (1.36–2.39; p < 0.001). The most important errors were: failure to identify the needle tip before injection, 2.40 (1.78–3.24; p < 0.001); and failure to quickly regain needle tip position when tip visibility was lost, 2.03 (1.5–2.75; p < 0.001). In conclusion, needle‐tracking technology improved performance in a quarter of subjects.
Efficacy of free-choice feeding of ground wheat or whole grain wheat and protein concentrate to turkeys*

The aim of this study was to determine body weight gains, feed intake and feed consumption patterns in turkeys, when offered a choice of various feed ingredients (protein-fat-mineral-vitamin concentrate pellets, ground-pelleted wheat and whole grain wheat). The experiment started on 264 male Hybrid Converter turkeys aged 4 weeks, divided into four experimental groups with six replicates per treatment and 11 birds per replicate. Group I birds were fed a complete pelleted diet formulated to meet the nutrient requirements of turkeys at 5-8 and 9-12 weeks of age. Turkeys in the other three groups had free access (FCF) to protein concentrate pellets (supplemented with fat, minerals and vitamins), ground-pelleted wheat (group II), ground-pelleted wheat and whole grain wheat (group III), and whole grain wheat (group IV). Throughout the experiment, average feed intake in the FCF groups accounted for 91.8 -93.0% of feed intake in group I. In the control group receiving the complete feed the intake of the components making up the protein concentrate used in the diets of groups II-IV was calculated as 43.2% of total feed intake, whereas the intake of protein concentrate in groups II, II and IV constituted 48.4, 46.2 and 65.6% of total feed intake, respectively. In comparison with group I, daily total protein intake was 6.7 and 5.4% lower in groups II and III, and 26.8% higher in group IV in the first feeding period; the differences between groups were less pronounced in the second feeding period. After 4 and 8 weeks of feeding, body weights (BW) of turkeys in the FCF groups were significantly lower than in group I (P=0.001 in both periods). In both feeding periods, total protein intake per kg weight gain in the experimental groups could be arranged in the following order: IV>III>II>I (P=0.001). FCF had no significant effect on excreta dry matter (DM) content and footpad dermatitis (FPD) incidence in 12-week-old turkeys.
Long-term shift in coastal fish communities before and after the collapse of Atlantic cod (Gadus morhua)

J. Scott P. McCain1*, Deneen J. Cull2‡, David C. Schneider2, and Heike K. Lotze1 Department of Biology, Dalhousie University, Halifax, NS, Canada Department of Ocean Sciences, Memorial University of Newfoundland, St. John’s, Newfoundland, Canada *Corresponding author: tel: +1 902 494 2146; fax: +1 902 494 3736; e-mail: j.scott. mccain@dal.ca Present address: Nalcor Energy, St. John’s, Newfoundland, Canada.
Effect of Job Satisfaction, Employee Engagement, and Organizational Citizenship Behaviour on Turnover Intention (Case Study in PT Iwaindo Internasional)

DOI: 10.21276/sjbms.2018. 3.4. 5 Abstract: This research is purposed to find out the influence of job satisfaction, employee engagement and organizational citizenship behaviour and its impact on turnover intention. Type of quantitative research with survey method. The population of all employees of PT. Iwaindo Internasional is 100 employees, non-probability sampling technique with a Saturated sample. The data analysis technique used is Multiple Regression. The results showed that job satisfaction had the significant effect on turnover intention, employee engagement had the significant effect on turnover intention, and organizational citizenship behaviour significantly influenced turnover intention. The simultaneous test (F test) shows job satisfaction, employee engagement, and organizational citizenship behaviour together have significant effect on turnover intention at PT. Iwaindo Internasional.
Structural Change and Global Trade Flows: Does an Emerging Giant Matter?

In this paper, we develop a novel trade&#8208;accounting framework that is based on a multi&#8208;country, multi&#8208;industry model of trade. The framework links observed changes in wages, sectoral employment shares, total labor force, and bilateral trade costs to changes in bilateral trade values at the sector level. In our application, we quantify the changes in trade patterns from 1995 to 2010 among 15 advanced and emerging market economies attributable to structural change in China, focusing on three manifestations of trade creation and destruction: China&#8217;s replacement of manufactured final goods exports to advanced economies at the expense of other economies; an expansion of China&#8217;s imports of manufactured final goods and commodities; and an expansion of China&#8217;s imports of parts and components that are then processed and exported as manufactured final goods to the advanced economies. Our main findings are: (a) scale effects have more than compensated for the loss of competitiveness due to higher wages in China; (b) China&#8217;s wage growth has been an economically more significant determinant of trade creation and destruction than its reallocation of labor across sectors, and (c) structural change in China has shifted other countries toward more commodity&#8208;intensive production.
Differentially Private Top-k Selection via Stability on Unknown Domain

We propose a new method that satisﬁes approximate differential privacy for top-k selection with unordered output in the unknown data domain setting, not relying on the full knowledge of the domain universe. Our algorithm only requires looking at the top-¯ k elements for any given ¯ k ≥ k , thus, enforcing the principle of minimal privilege. Unlike previous methods, our privacy parameter ε does not scale with k , giving improved applicability for scenarios of very large k . Moreover, our novel construction, which combines the sparse vector technique and stability efﬁciently, can be applied as a general framework to any type of query, thus being of independent interest. We extensively compare our algorithm to previous work of top-k selection on the unknown domain, and show, both analytically and on experiments, settings where we outperform the current state-of-the-art.
Investigating the relationship between how a chief complaint is expressed and the patient workflow

Objective: Emergency departments and hospital emergency departments are important due to their critical role in providing urgent medical care to patients in dire need of medical interventions. Checking bottlenecks in new conditions and planning to reduce bed occupancy and hospitalization is needed. The purpose of this study is to investigate the relationship between the patient’s chief complaint and their departure to the emergency room.Methods: From non-traumatic patients referred to the emergency department of Imam Reza Hospital during 2018, about 57000 patients were selected and enrolled in the study. Then, age, sex, initial diagnosis, time of the final decision, and time of departure from the emergency department as well as hospitalization ward were included in the checklist. Patients whose documentation was incomplete were excluded. Data were entered into SPSS software version 15.0 and descriptive statistics (normal distribution, average of time, minimum time and maximum time, confidence interval, mode, and median, etc.) were used for descriptive analysis and linear regression was used to analyze the correlation among findings.Results: There was a significant relationship between chief complaint and the length of stay in the emergency department (P = 0.046) and patients with dyspnea due to heart disease, bloody vomit, bloody stool, constipation, jaundice, anemia, decreased level of consciousness, diabetes, complications of diabetes, shortness of breath and kidney injury stayed longer in the emergency room compared to other complaints.Conclusion: The patient’s manner of expressing and chief complaint has an impact on the length of time they wait to leave the emergency room. Also, most patients with problems related to internal medicine have the longest time in the emergency room; in particular gastrointestinal patients have the longest stay in the emergency room.