Miracle-dz/UniFAR-FTUs huggingface dataset:
Overoxidation and Oligomerization of Trypanosoma cruzi Cytosolic and Mitochondrial Peroxiredoxins

Peroxiredoxins (Prxs) have been shown to be important enzymes for trypanosomatids, counteracting oxidative stress and promoting cell infection and intracellular survival. In this work, we investigate the in vitro sensitivity to overoxidation and the overoxidation dynamics of Trypanosoma cruzi Prxs in parasites in culture and in the infection context. We showed that recombinant m-TXNPx, in contrast to what was observed for c-TXNPx, exists as low molecular mass forms in the overoxidized state. We observed that T. cruzi Prxs were overoxidized in epimastigotes treated with oxidants, and a significant proportion of the overoxidized forms were still present at least 24 h after treatment suggesting that these forms are not actively reversed. In in vitro infection experiments, we observed that Prxs are overoxidized in amastigotes residing in infected macrophages, demonstrating that inactivation of at least part of the Prxs by overoxidation occurs in a physiological context. We have shown that m-TXNPx has a redox-state-dependent chaperone activity. This function may be related to the increased thermotolerance observed in m-TXNPx-overexpressing parasites. This study suggests that despite the similarity between protozoan and mammalian Prxs, T. cruzi Prxs have different oligomerization dynamics and sensitivities to overoxidation, which may have implications for their function in the parasite life cycle and infection process.
The Role of Guidance and Counseling Teacher in Developing Students’ Religious Moderation Behavior at Madrasah

Abstract: Indonesia is currently facing extremism, radicalism, hate speech, and the breakdown of interfaith relations, which require that teachers fulfill their roles in developing students' religious moderation behavior. This study aims to describe the role of Guidance and Counseling teachers in developing students' religious moderation behavior at MAN Bintan. This research is classified as qualitative research when viewed from the aspect of data. The research activity was conducted at MAN Bintan from January to April 2022. The subjects for data collection in this study were Guidance and Counseling teachers. Data collection was performed through interviews, observation, and documentation. Data analysis was carried out by reducing, presenting, and verifying the data. The findings of this study demonstrate that Guidance and Counseling teachers play a central role in the development of students' religious moderation behavior at MAN Bintan, which is reflected in their roles as informants, facilitators, motivators, and mentors. Abstrak: Bangsa Indonesia sedang menghadapi ekstremisme, radikalisme, ujaran kebencian, hingga retaknya hubungan antarumat beragama sehingga guru dituntut untuk melaksanakan perannya dalam rangka mengembangkan perilaku moderasi beragama siswa. Penelitian ini mempunyai tujuan untuk mendeskripsikan peran guru Bimbingan dan Konseling dalam mengembangkan perilaku moderasi beragama peserta didik di MAN Bintan.Penelitian ini tergolong kepada penelitian kualitatif bila dilihat dari aspek datanya. Kegiatan penelitian ini dilaksanakan di MAN Bintan dari bulan Januari hingga April tahun 2022. Subyek untuk perolehan sumber data dalam penelitian ini ialah guru Bimbingan dan Konseling. Pengumpulan data terlaksana melalui kegiatan wawancara, observasi, dan dokumentasi. Analisis data dilakukan dengan reduksi, display dan verifikasi data. Temuan penelitian ini memperlihatkan bahwa guru Bimbingan dan Konseling memainkan posisi sentral dalam pengembangan perilaku moderasi beragama peserta didik di MAN Bintan yang tercermin dari perannya sebagai informator, fasilitator, motivator, dan pembimbing.
Thermoresponsive Shape Memory Polymer Based on Polylactic Acid/Styrene-Butadiene-Styrene Blends with Different Inorganic Metal Fillers

In this study, polylactic acid (PLA) blended with 30 wt% styrene-butadiene-styrene (SBS) (70PLA/30SBS) was added with different fillers; Erbium Oxide (Er2O3), Halloysite Nanotubes (HNT) and Tungsten Carbide (WC2) to investigate the effect of the filler on the shape fixity (Rf) and shape recovery (Rr) at different deformation and recovery times, rheological and morphological properties. The tubular structure of HNT led to the reduction of Rf when immersed longer during the deformation phase. Meanwhile, the presence of Er2O3 improved the Rr and Rr with longer deformation and recovery times, respectively. The blend with HNT has the highest viscosity while the blend with 70PLA/30SBS-Er2O3 indicated lower viscosity than the unfilled blend. All filled blends indicated the sea-island structure with the SBS droplets in PLA continuous phase. The elements identification made on the surface of the samples illustrates that the fillers were well-distributed in 70PLA/30SBS blends. The insignificant improvement of shape memory in the presence of the thermal conductive fillers due to the dominance of the restriction of chain motion due to the presence of fillers compared with increment of thermal conductivity at low filler loading.
Reproductive-dependent effects of B vitamin deficiency on lifespan and physiology

B vitamins constitute essential micronutrients in animal organisms, executing crucial roles in numerous biological processes. B vitamin deficiency can result in severe health consequences, including the impairment of reproductive functions and increased susceptibility to age-related diseases. However, the understanding of how reproduction alters the requirements of each individual B vitamins for healthy aging and lifespan remains limited. Here, utilizing Drosophila as a model organism, we revealed the substantial impacts of deficiencies in specific B vitamins on lifespan and diverse physiological functions, with the effects being significantly shaped by reproductive status. Notably, the dietary absence of VB1, VB3, VB5, VB6, or VB7 significantly decreased the lifespan of wild-type females, yet demonstrated relatively little effect on ovoD1 infertile mutant females’ lifespan. B vitamin deficiencies also resulted in distinct impacts on the reproduction, starvation tolerance and fat metabolism of wild-type females, though no apparent effects were observed in the infertile mutant females. Moreover, a deficiency in VB1 reshaped the impacts of macronutrient intervention on the physiology and lifespan of fertile females in a reproductive-dependent manner. Overall, our study unravels that the reproductive status of females serves as a critical modulator of the lifespan and physiological alterations elicited by B-vitamin deficiencies.
Results of a CLM4 Land Surface Simulation over China Using a Multisource Integrated Land Cover Dataset

Abstract In this study, the high-accuracy multisource integrated Chinese land cover (MICLCover) dataset was used in version 4 of the Community Land Model (CLM4) to assess how the new land cover information affected land surface simulation over China. Compared to the default land cover dataset in CLM4, the MICL data indicated lower values for bare soil (14.6% reduction), needleleaf tree (3.6%), and broadleaf tree (1.9%); higher values for shrub cover (1.8% increase), grassland (9.9%), cropland (5.0%), glaciers (0.5%), lakes (1.6%), and wetland (1.1%); and unchanged for urban areas. Two comparative CLM4 simulations were conducted for the 33-yr period from 1972 to 2004, one using the MICL dataset and the other using the default dataset. The results revealed that the MICL data produced a 0.3% lower mean annual surface albedo over China than the original data. The largest contributor to the reduced value was semiarid regions (2.1% reduction). The MICL-data albedo value agreed more closely with observations (MODIS broadband black-sky albedo products) over arid and semiarid regions than for the original data to some extent. The simulated average sensible heat flux over China increased by only 0.1 W m-2 owing to the reduced values in arid and semiarid regions, as opposed to increases in humid and semihumid regions, while an increased latent heat flux of 1 W m-2 was reflected in almost identical changes over the whole region. In addition, the mean annual runoff simulated by CLM4 using MICL data decreased by 6.8 mm yr-1, primarily due to large simulated decreases in humid regions.
Parent and teacher perceptions of ESL and non-ESL preschoolers’ school readiness

Abstract In this study, we explore parent and teacher perceptions of school readiness (SR) among 4-year-olds learning English as a second language (ESL) and native English-speaking 4-year-olds and compare these perceptions to child scores. Child assessments focused on letter and numeral knowledge. These data were collected from 387 children (52% boys), including 28% ESL children. Adult perspectives were collected from 141 parents (who rated one child each) and from 30 teachers (who rated 380 children). Findings indicated (a) children’s letter and numeral knowledge did not significantly vary by ESL status; (b) teachers, but not parents, rated ESL children significantly lower on literacy knowledge compared to non-ESL children; (c) teacher and, to a lesser extent, parent perceptions of children’s literacy and numeracy knowledge were positively associated with children’s scores; and (d) teacher perception of numeracy was significantly more aligned with children’s numeral knowledge compared to parent perception. Discussion of these findings is included.
Effects of Lower Dietary Calcium and Phosphorus on Growth Performance and Bone Mineralizatıon of Broilers

This experiment was carried out to investigate the effects of reduced dietary calcium (Ca) and non-phytate-phosphorus (NPP) levels at 2:1 constant ratio on performance, carcase parameters and bone mineralization of Ross-308 broilers. A total of 11400 one-day-old chicks were randomly allocated to five dietary treatments with twelve replicates and were fed starter diets including either recommended (control treatment, T1) or a 6.25% lower level of both Ca and NPP according to breeder’s recommendations during starter period (SP). After SP, control treatment (T1) continued to be provided through diets containing 0.87 and 0.78 % Ca for grower (GP) and finisher periods (FP), respectively, while 6.25 % reduced group was divided into 4 dietary treatments regarding extent of decrease in Ca and NPP levels and provided by diets containing 0.79;0.65 (T2), 0.79;0.60 (T3), 0.75;0.65 (T4), and 0.75;0.60 (T5) % Ca for GP and FP, respectively. After SP, moderate and even substantial reduction of Ca and NPP significantly decreased feed intake (FI) (quadratic, P<0.05), but obtained similar body weight gain (BWG) and FCR compared to the control (P>0.05). On the other hand, reduced dietary Ca through T1 to T5 significantly decreased the total Ca and NPP intake of broilers (linear and quadratic, P<0.01), and accompanied to significant linear and quadratic relationship between Ca intake and FCR and BWG respectively. It can be concluded that reducing Ca level down to 0.75 and 0.60 % in grower and finisher phase, respectively are possible without compromising the growth performance and bone mineralization of modern broilers.
Hydrological and Structural Monitoring for Flood Risk Mitigation in Cosenza Urban Area (Southern Italy)

The evaluation of flood risk in urban areas characterized by high vulnerability indices is a fundamental task in order to undertake any mitigation action. When flood-induced phenomena affect structures (buildings, bridges, river banks, etc.) particularly in areas adjacent to rivers, as for the city of Cosenza, the real time detection of any change in the structural response is crucial for a proper safety level assessment. In the present work, a framework for remote monitoring of hydrological events and related structural behaviour is proposed. Data pertaining to the hydro-meteorological event are collected mainly through a series of ultrasonic hydrometers, different types of rain gauges and webcams, to allow a rough estimate of the expected action on the structures. The structural response is monitored through accelerometers (or other instruments) which allows identifying the evolution of the dynamic behaviour, in order to detect insurgent damage phenomena. The acquired structural measurements are employed to tune both fine structural models or rough simplified models. Moreover, the structural monitoring system allows to estimate damages due to other natural events, such as earthquakes, which well suits current philosophies of multi-risk assessment. This study is carried out within the “Smart integrated monitoring system for safe and resilient communities” action of the NRRP Tech4you project.
CRITICAL SUCCESS FACTORS FOR ACCOUNTING INFORMATION SYSTEM IMPLEMENTATION: EVIDENCE FROM MANUFACTURING COMPANIES

Not all manufacturing companies are successful in implementing an integrated Accounting Information System (AIS), it requires the right combination of technology and humans as the main drivers. This research explored the relationship between organizational commitment from AIS users, knowledge of accounting managers, and data quality on the success of AIS implementation in manufacturing companies. A quantitative approach used the SEM-PLS method on 50 manufacturing companies in Indonesia. Meanwhile, the research results stated that data quality and knowledge of accounting managers had a positive and significant effect on the success of AIS implementation, while organizational commitment did not have a significant effect. This research implied that manufacturing companies could emphasize quality data and increase the knowledge of their managers to provide value to the organization through AIS.
Machine learning-derived cycle length variability metrics predict spontaneously terminating ventricular tachycardia in implantable cardioverter defibrillator recipients

Abstract Aims Implantable cardioverter defibrillator (ICD) therapies have been associated with increased mortality and should be minimized when safe to do so. We hypothesized that machine learning-derived ventricular tachycardia (VT) cycle length (CL) variability metrics could be used to discriminate between sustained and spontaneously terminating VT. Methods and results In this single-centre retrospective study, we analysed data from 69 VT episodes stored on ICDs from 27 patients (36 spontaneously terminating VT, 33 sustained VT). Several VT CL parameters including heart rate variability metrics were calculated. Additionally, a first order auto-regression model was fitted using the first 10 CLs. Using features derived from the first 10 CLs, a random forest classifier was used to predict VT termination. Sustained VT episodes had more stable CLs. Using data from the first 10 CLs only, there was greater CL variability in the spontaneously terminating episodes (mean of standard deviation of first 10 CLs: 20.1 ± 8.9 vs. 11.5 ± 7.8 ms, P < 0.0001). The auto-regression coefficient was significantly greater in spontaneously terminating episodes (mean auto-regression coefficient 0.39 ± 0.32 vs. 0.14 ± 0.39, P < 0.005). A random forest classifier with six features yielded an accuracy of 0.77 (95% confidence interval 0.67 to 0.87) for prediction of VT termination. Conclusion Ventricular tachycardia CL variability and instability are associated with spontaneously terminating VT and can be used to predict spontaneous VT termination. Given the harmful effects of unnecessary ICD shocks, this machine learning model could be incorporated into ICD algorithms to defer therapies for episodes of VT that are likely to self-terminate.
Local roots and global wings: television drama and hybridity in Moroccan cultural identities

OF THE DISSERTATION Local Roots and Global Wings: Television Drama and Hybridity in Moroccan Cultural Identities By JILL G. CAMPAIOLA Dissertation Director: Dr. Deepa Kumar “Local Roots and Global Wings: Television Drama and Hybridity in Moroccan Cultural Identities” provides a snapshot of the Moroccan film and television industry in 2009 and 2010, on the eve of the Arab Uprisings. The dissertation examines how Moroccan state media elites and filmmakers struggle to instill seeds of democratic change within media structures and local media texts. It also shows how the influx of television dramas from Egypt, Syria, Turkey, and the U.S. provides an opportunity for ‘hybrid’ identities to emerge and allows viewers to interrogate the meaning of ‘modernity’ and ‘democracy’ at home and in various cultural contexts. I examine how the process of cultural hybridization occurs through mass media. Specifically, I examine how television series coming from various locations redefine cultural boundaries in Morocco and allow individuals to form hybrid identities. Through a textual analysis of the most popular local and foreign television series shown in Morocco, as well as ethnographic fieldwork focusing on state elites, filmmakers and audiences, my dissertation reveals how local and foreign influences pervade the collective Moroccan imagination through state, production, and audience choices.
Studies on Soil Physical and Chemical Properties of Abandoned Land

The soil physical and chemical properties of natural grassland and abandoned land were studied.The results showed that the organic matter,total N,hydrolytic N increased firstly,then reduced with the increase of abandoned time.The loss of organic C got up to 59.4% in abandoned land.In 0~20cm,the content of 0.25~0.05mm sand increased gradually,the average content of sand in the abandoned land was up to 76.84%. The contents of silt and sand reduced gradually,the soil mechanical composition became coarse.The soil retaining water ability was reduced,top soil bulk density was increased,but soil water content was lower than that in natural grassland.
Aerobic Exercise Ameliorates Liver Injury in Db/Db Mice by Attenuating Oxidative Stress, Apoptosis and Inflammation Through the Nrf2 and JAK2/STAT3 Signalling Pathways

Objective Diabetes mellitus (DM) implicates oxidative stress, apoptosis, and inflammation, all of which may contribute liver injury. Aerobic exercise is assured to positively regulate metabolism in the liver. This project was designed to investigate whether and how aerobic exercise improves DM-induced liver injury. Methods Seven-week-old male db/db mice and age-matched m/m mice were randomly divided into a rest control group or a group that received 12 weeks of aerobic exercise by treadmill training (10 m/min). Haematoxylin and eosin (HE) staining, electron microscopy, Oil Red O staining and TUNEL assays were used to evaluate the histopathological changes in mouse liver. The serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), triglyceride (TRIG), cholesterol (CHOL) were analyzed by serum biochemical analysis. Interleukin-6 (IL-6), tumour necrosis factor-α (TNF-α), and tissue levels of malondialdehyde (MDA) and superoxide dismutase (SOD) were analyzed via ELISA. Nuclear factor E2-associated factor-2 (Nrf2), nuclear factor κB (NF-κB) and JAK2/STAT3 pathway-related proteins were measured by immunofluorescence, Western blotting and q-PCR. F4/80 expression in liver tissues was assessed by immunohistochemistry. Results In diabetic mice, exercise training significantly decreased the levels of serum TRIG, CHOL, IL-6, TNF-α, ALT and AST; prevented weight gain, hyperglycaemia, and impaired glucose and insulin tolerance. Morphologically, exercise mitigated the diabetes-induced increase in liver tissue microvesicles, inflammatory cells, F4/80 (macrophage marker) levels, and TUNEL-positive cells. In addition, exercise reduced the apoptosis index, which is consistent with the results for caspase-3 and Bax. Additionally, exercise significantly increased SOD activity, decreased MDA levels, activated Nrf2 and decreased the expression of NF-kB, phosphorylated JAK2 and STAT3 proteins in the livers of diabetic mice. Conclusion This study demonstrated that aerobic exercise reversed liver dysfunction in db/db mice with T2DM by reducing oxidative stress, apoptosis and inflammation, possibly by enhancing Nrf2 expression and inhibiting the JAK2/STAT3 cascade response.
Unveiling Peripherally Inserted Central Catheter Fractures and Related Complications in the Neonatal Intensive Care Unit: A Concise Review

Peripherally inserted central catheters (PICCs) have become popular over tunneled catheters in neonatal intensive care units (NICUs) due to their ease of use and convenience. Although rare, a PICC fracture can be a severe and potentially fatal complication. This narrative review aims to identify factors predisposing neonates to PICC fracture and related complications, such as catheter jamming, and explore strategies for preventing and detecting this complication. A thorough search of PubMed and Google Scholar was conducted using relevant keywords to identify articles discussing PICC fracture in neonates. The review encompassed English-language literature on PICC fracture in neonates, with additional pertinent publications identified through citation searching. The incidence of PICC fracture in neonates varies from less than 1% to 10%, with a higher risk associated with prolonged catheterization, lower gestational age and lower birth weight, and the use of multi-lumen catheters. PICC fractures can occur during insertion, maintenance, or removal. Factors such as catheter duration, gestational age, birth weight, and catheter type increase the risk of PICC fracture. Excessive syringe pressure, securement failure, and excessive force during removal are contributing factors. Catheter fatigue and thin-walled catheter design are common causes of breakage. Preventive measures include proper training of healthcare providers, regular monitoring, early recognition, and prompt catheter removal upon fracture. Preventing and detecting PICC fractures is crucial for neonatal safety. Vigilance during insertion, maintenance, and removal, along with care to avoid excessive force during removal and high pressure during flushing, can help prevent catheter breakage. More research is required to improve prevention strategies for PICC fractures in neonates.
Piecing Together the Triassic/Jurassic Stratigraphy Along the South Flank of the Uinta Mountains, Northeast Utah: A Preliminary Analysis

Abstract Nomenclature for the Upper Triassic and Lower Jurassic strata along the south flank of the Uinta Mountains has been somewhat confusing because of the position of the area between southern Wyoming, where one set of names is used, and central/southern Utah where a different set of formation names is used. The Nugget Sandstone or Glen Canyon Sandstone of the eastern Uinta Mountains overlies the Upper Triassic Popo Agie or Chinle Formation. The nature of the contact between these two formations is unclear both in stratigraphic location and conformability. The Chinle Formation consists, in ascending order, of the Gartra Member, the purple unit, the ocher unit, and the upper red unit. The overlying Nugget Sandstone consists of two members, the lower Bell Springs Member(? ) and the overlying unnamed cross-bedded member, typically believed to be Navajo Sandstone equivalent. These two units of the Nugget Sandstone are thought to represent the Glen Canyon Group of the Colorado Plateau, although no obvious Wingate or Kayenta Formation equivalents have been recognized. The lower unnamed unit was deposited in a marine tidal flat environment, quite different from the mainly eolian environment of the rest of the Nugget Sandstone. The Bell Springs Member(? ) may be entirely Upper Triassic, based upon dinosaur tracks found within it, while the upper unit’s age is probably Jurassic. In our current mapping efforts in the Donkey Flat, Steinaker Reservoir, Dry Fork, and Lake Mountain quadrangles, we intend to include this lower Nugget member as a separate unit and call it the Bell Springs Member(? ).