Miracle-dz/UniFAR-FTUs huggingface dataset:
On-Admission Anemia and Survival Rate in COVID-19 Patients

Background: Anemia often worsens the severity of respiratory illnesses, and few studies have so far elucidated the impact of anemia on COVID-19 infection. This study aimed to evaluate the effect of anemia at admission on the overall survival of COVID-19 patients using AFT models. Methods: This registry-based, single-center retrospective cohort study was conducted in a university hospital in Ilam, the southwest of Iran, between March 2020 and September 2021. AFT models were applied to set the data of 2,441 COVID-19 patients. Performance of AFT models was assessed using AIC and Cox-Snell residual. On-admission anemia was defined as Hb concentration <120 g/l in men, <110 g/l in women, and <100 g/l in pregnant women. Results: The median in-hospital survival times for anemic and non-anemic patients were 27 and 31 days, respectively. Based on the AIC and Cox-Snell residual graph, the Weibull model had the lowest AIC and it was the best fitted model to the data set among AFT models. In the adjusted model, the results of the Weibull model suggested that the anemia (adjusted TR: 1.04; 95% CI: 1.00-1.08; p = 0.03) was the accelerated factor for progression to death in COVID-19 patients. Each unit of increase in hemoglobin in COVID-19 patients enhanced the survival rate by 4%. Conclusion: Anemia is an independent risk factor associated with the risk of mortality from COVID-19 infection. Therefore, healthcare professionals should be more sensitive to the Hb level of COVID-19 patients upon admission.
Ginsenoside Rb1 reduces oxidative/carbonyl stress damage and ameliorates inflammation in the lung of streptozotocin-induced diabetic rats

Abstract Context Ginsenoside Rb1 (Rb1) is a biologically active component of ginseng [Panax ginseng C.A. Meyer (Araliaceae)]. Objective This study determined the underlying mechanisms of Rb1 treatment that acted on diabetes-injured lungs in diabetic rats. Materials and methods Streptozotocin (STZ)-induced diabetic rat model was used. Male Sprague-Dawley (SD) rats were divided into four groups (n = 10): control, Rb1 (20 mg/kg), insulin (15 U/kg to attain the euglycaemic state) and diabetic (untreated). After treatment for six weeks, oxidative stress assay; histological and ultrastructure analyses; TNF-α, TGF-β, IL-1 and IL-6 protein expression analyses; and the detection of apoptosis were performed. Results There was decreased activity of SOD (3.53-fold), CAT (2.55-fold) and GSH (1.63-fold) and increased levels of NO (4.47-fold) and MDA (3.86-fold) in the diabetic group from control. Rb1 treatment increased SOD (2.4-fold), CAT (1.9-fold) and GSH (1.29-fold) and decreased the levels of NO (1.76-fold) and MDA (1.51-fold) as compared with diabetic rats. The expression of IL-6 (5.13-fold), IL-1α (2.35-fold), TNF-α (2.35-fold) and TGF-β (2.39-fold) was increased in diabetic rats from control. IL-6 (2.43-fold), IL-1α (2.27-fold), TNF-α (1.68-fold) and TGF-β (2.3-fold) were decreased in the Rb1 treatment group. Diabetes increased the apoptosis rate (2.23-fold vs. control), and Rb1 treatment decreased the apoptosis rate (1.73-fold vs. the diabetic rats). Rb1 and insulin ameliorated lung tissue injury. Discussion and conclusions These findings indicate that Rb1 could be useful for mitigating oxidative damage and inflammatory infiltration in the diabetic lung.
Diabetic cardiomyopathy: a brief summary on lipid toxicity

Diabetes mellitus (DM) is a serious epidemic around the globe, and cardiovascular diseases account for the majority of deaths in patients with DM. Diabetic cardiomyopathy (DCM) is defined as a cardiac dysfunction derived from DM without the presence of coronary artery diseases and hypertension. Patients with either type 1 or type 2 DM are at high risk of developing DCM and even heart failure. Metabolic disorders of obesity and insulin resistance in type 2 diabetic environments result in dyslipidaemia and subsequent lipid‐induced toxicity (lipotoxicity) in organs including the heart. Although various mechanisms have been proposed underlying DCM, it remains incompletely understood how lipotoxicity alters cardiac function and how DM induces clinical heart syndrome. With recent progress, we here summarize the latest discoveries on lipid‐induced cardiac toxicity in diabetic hearts and discuss the underlying therapies and controversies in clinical DCM.
THE FERMI/LAT SKY AS SEEN BY INTEGRAL/IBIS

In this Letter we present the result of the cross correlation between the fourth INTEGRAL/IBIS soft gamma-ray catalog, in the range 20–100 keV, and the Fermi LAT bright source list of objects emitting in the 100 MeV–100 GeV range. The main result is that only a minuscule part of the more than 720 sources detected by INTEGRAL and the population of 205 Fermi LAT sources are detected in both spectral regimes. This is in spite of the mCrab INTEGRAL sensitivity for both galactic and extragalactic sources and the breakthrough, in terms of sensitivity, achieved by Fermi at MeV–GeV energies. The majority of the 14 Fermi LAT sources clearly detected in the fourth INTEGRAL/IBIS catalog are optically identified active galactic nuclei (10) complemented by two isolated pulsars (Crab and Vela) and two high-mass X-ray binaries (LS I +61°303 and LS 5039). Two more possible associations have been found: one is 0FGL J1045.6-5937, possibly the counterpart at high energy of the massive colliding wind binary system Eta Carinae, discovered to be a soft gamma ray emitter by recent INTEGRAL observations and 0FGL J1746.0-2900 coincident with IGR J17459-2902, but still not identified with any known object at lower energy. For the remaining 189 Fermi LAT sources no INTEGRAL counterpart was found and we report the 2σ upper limit in the energy band 20–40 keV.
POPULATION III HYPERNOVAE

Population III supernovae have been of growing interest of late for their potential to directly probe the properties of the first stars, particularly the most energetic events that are visible near the edge of the observable universe. Until now, hypernovae, the unusually energetic Type Ib/c supernovae that are sometimes associated with gamma-ray bursts, have been overlooked as cosmic beacons at the highest redshifts. In this, the latest of a series of studies on Population III supernovae, we present numerical simulations of 25–50 M☉ hypernovae and their light curves done with the Los Alamos RAGE and SPECTRUM codes. We find that they will be visible at z = 10–15 to the James Webb Space Telescope and z = 4–5 to the Wide-Field Infrared Survey Telescope, tracing star formation rates in the first galaxies and at the end of cosmological reionization. If, however, the hypernova crashes into a dense shell ejected by its progenitor, it is expected that a superluminous event will occur that may be seen at z ∼ 20 in the first generation of stars.
Planar defect–free pure red perovskite light-emitting diodes via metastable phase crystallization

Solution-processable all-inorganic CsPbI3−xBrx perovskite holds great potential for pure red light-emitting diodes. However, the widely existing defects in this mixed halide perovskite markedly limit the efficiency and stability of present light-emitting diode devices. We here identify that intragrain Ruddlesden-Popper planar defects are primary forms of such defects in the CsPbI3−xBrx thin film owing to the lattice strain caused by inhomogeneous halogen ion distribution. To eliminate these defects, we develop a stepwise metastable phase crystallization strategy to minimize the CsPbI3−xBrx perovskite lattice strain, which brings planar defect–free CsPbI3−xBrx thin film with improved radiative recombination, narrowed emission band, and enhanced spectral stability. Using these high-quality thin films, we fabricate spectrally stable pure red perovskite light-emitting diodes, showing 17.8% external quantum efficiency and 9000 candela meter−2 brightness with color coordinates required by Rec. 2020.
Effectiveness of remote physiotherapeutic e-Health interventions on pain in patients with musculoskeletal disorders: a systematic review

Abstract Purpose To systematically review the literature on effectiveness of remote physiotherapeutic e-Health interventions on pain in patients with musculoskeletal disorders. Materials and methods Using online data sources PubMed, Embase, and Cochrane in adults with musculoskeletal disorders with a pain-related complaint. Remote physiotherapeutic e-Health interventions were analysed. Control interventions were not specified. Outcomes on effect of remote e-Health interventions in terms of pain intensity. Results From 11,811 studies identified, 27 studies were included. There is limited evidence for the effectiveness for remote e-Health for patients with back pain based on five articles. Twelve articles studied chronic pain and the effectiveness was dependent on the control group and involvement of healthcare providers. In patients with osteoarthritis (five articles), total knee surgery (two articles), and knee pain (three articles) no significant effects were found for remote e-Health compared to control groups. Conclusions There is limited evidence for the effectiveness of remote physiotherapeutic e-Health interventions to decrease pain intensity in patients with back pain. There is some evidence for effectiveness of remote e-Health in patients with chronic pain. For patients with osteoarthritis, after total knee surgery and knee pain, there appears to be no effect of e-Health when solely looking at reduction of pain. Implications for rehabilitation This review shows that e-Health can be an effective way of reducing pain in some populations. Remote physiotherapeutic e-Health interventions may decrease pain intensity in patients with back pain. Autonomous e-Health is more effective than no treatment in patients with chronic pain. There is no effect of e-Health in reduction of pain for patients with osteoarthritis, after total knee surgery and knee pain.
Validation of case definition algorithms for the ascertainment of congenital anomalies

Congenital anomalies (CA) are one of the leading causes of infant mortality and long‐term disability. Many jurisdictions rely on health administrative data to monitor these conditions. Case definition algorithms can be used to monitor CA; however, validation of these algorithms is needed to understand the strengths and limitations of the data. This study aimed to validate case definition algorithms used in a CA surveillance system in British Columbia (BC), Canada.
Ellipticity of Structures in CMB Sky Maps

We study the ellipticity of contour lines in the sky maps of the cosmic microwave background (CMB) as well as other measures of elongation. The sensitivity of the elongation on the resolution of the CMB maps, which depends on the pixelization and the beam profile of the detector, is investigated. It is shown that the current experimental accuracy does not allow one to discriminate between cosmological models which differ in curvature by ΔΩtot = 0.05. Analytical expressions are given for the case that the statistical properties of the CMB are those of two-dimensional Gaussian random fields.
HOW ELSE CAN WE DETECT FAST RADIO BURSTS?

We discuss possible electromagnetic signals accompanying Fast Radio Bursts (FRBs) that are expected in the scenario where FRBs originate in neutron star magnetospheres. For models involving Crab-like giant pulses, no appreciable contemporaneous emission is expected at other wavelengths. However, magnetar giant flares, driven by the reconfiguration of the magnetosphere, can produce both contemporaneous bursts at other wavelengths as well as afterglow-like emission. We conclude that the best chances are: (i) prompt short GRB-like emission, (ii) a contemporaneous optical flash that can reach naked eye peak luminosity (but only for a few milliseconds), and (iii) a high-energy afterglow emission. Case (i) could be tested by coordinated radio and high-energy experiments. Case (ii) could be seen in a coordinated radio-optical surveys, e.g., by the Palomar Transient Factory in a 60 s frame as a transient object of m = 15–20 mag with an expected optical detection rate of about 0.1 hr−1, an order of magnitude higher than in radio. Shallow, but large-area sky surveys such as ASAS-SN and EVRYSCOPE could also detect prompt optical flashes from the more powerful Lorimer-burst clones. The best constraints on the optical to radio power for this kind of emission could be provided by future observations with facilities like Large Synoptic Survey Telescope. Case (iii) might be seen in relatively rare cases that the relativistically ejected magnetic blob is moving along the line of sight.
An accretion disc-irradiation hybrid model for the optical/UV variability in radio-quiet quasars

The optical/ultraviolet (UV) variability of quasars has been discovered to be correlated with other quasar properties, such as luminosity, black hole mass and rest-frame wavelength. However,the origin of variability has been a puzzle so far. In this work, we upgrade the accretion disc model (Li & Cao 2008), which assumed the variability is caused by the change of global mass accretion rate, by constraining the disc size to match the viscous timescale of accretion disc to the variability timescale observed and by including the irradiation/X-ray reprocessing to make the emitted spectrum become steeper. We find this hybrid model can reproduce the observed bluer-when-brighter trend quite well, which is used to validate the theoretical model by several works recently. The traditional correlation between the variability amplitude and rest-frame wavelength can also be well fitted by our model. In addition, a weak positive correlation between variability amplitude and black hole mass is present, qualitatively consistent with recent observations.
Hiding its age: the case for a younger bulge

The determination of the age of the bulge has led to two contradictory results. On the one side, the color-magnitude diagrams in different bulge fields seem to indicate a uniformly old ($>$10 Gyr) population. On the other side, individual ages derived from dwarfs observed through microlensing events seem to indicate a large spread, from $\sim$ 2 to $\sim$ 13 Gyr. Because the bulge is now recognised as being mainly a boxy peanut-shaped bar, it is suggested that disk stars are one of its main constituents, and therefore also stars with ages significantly younger than 10 Gyr. Other arguments as well point to the fact that the bulge cannot be exclusively old, and in particular cannot be a burst population, as it is usually expected if the bulge was the fossil remnant of a merger phase in the early Galaxy. In the present study, we show that given the range of metallicities observed in the bulge, a uniformly old population would be reflected into a significant spread in color at the turn-off which is not observed. Inversely, we demonstrate that the correlation between age and metallicity expected to hold for the inner disk would conspire to form a color-magnitude diagram with a remarkably small spread in color, thus mimicking the color-magnitude diagram of a uniformly old population. If stars younger than 10 Gyr are part of the bulge, as must be the case if the bulge has been mainly formed through dynamical instabilities in the disk, then a very small spread at the turn-off is expected, as seen in the observations.
Prevalence of vascular disruption anomalies and association with young maternal age: A EUROCAT study to compare the United Kingdom with other European countries

Younger mothers are at a greater risk of having a pregnancy with gastroschisis and the risk is higher in the United Kingdom than other European countries. Gastroschisis is thought to be a vascular disruption anomaly and the aim of this study was to analyze the prevalence of other possible vascular disruption anomalies to determine whether both the younger maternal age and the UK associations also occur with these anomalies.
Anisotropy and directional pinning in YBa2Cu3O7−x with BaZrO3 nanorods

Measurements of anisotropic transport properties (dc and high-frequency regime) of driven vortex matter in YBa2Cu3O7−x with elongated strong-pinning sites (c-axis aligned, self-assembled BaZrO3 nanorods) are used to demonstrate that the effective-mass angular scaling takes place only in intrinsic physical quantities (flux-flow resistivity), and not in pinning-related Labusch parameter and critical currents. Comparison of the dynamics at different time scales shows evidence for a transition of the vortex matter toward a Mott phase, driven by the presence of nanorods. The strong pinning in dc arises partially from a dynamic effect.
SPECTRAL LINE SURVEY TOWARD THE SPIRAL ARM OF M51 IN THE 3 AND 2 mm BANDS

We have conducted a spectral line survey in the 3 and 2 mm bands toward two positions in a spiral arm of M51 (NGC 5194) with the Institut de Radioastronomie Millimétrique 30 m telescope. In this survey, we have identified 13 molecular species, including CN, CCH, N2H+, HNCO, and CH3OH. Furthermore, six isotopologues of the major species have been detected. On the other hand, SiO, HC3N, CH3CN, and deuterated species such as DCN and DCO+ were not detected. The deuterium fractionation ratios are evaluated to be less than 0.8% and 1.2% for DCN/HCN and DCO+/HCO+, respectively. By comparing the results of the two positions with different star formation activities, we have found that the observed chemical compositions do not strongly depend on star formation activities. They seem to reflect a chemical composition averaged over the 1 kpc scale region including many giant molecular clouds. Among the detected molecules CN, CCH, and CH3OH are found to be abundant. High abundances of CN and CCH are consistent with the above picture of a widespread distribution of molecules because they can be produced by photodissociation. On the other hand, it seems likely that CH3OH is liberated in the gas phase by shocks associated with large-scale phenomena such as cloud–cloud collisions and/or by nonthermal desorption processes such as photoevaporation due to cosmic-ray-induced UV photons. The present result demonstrates a characteristic chemical composition of a giant molecular cloud complex in the spiral arm, which can be used as a standard reference for studying chemistry in active galactic nuclei and starbursts.
Offspring affected with in utero Zika virus infection retain molecular footprints in the bone marrow and blood cells

ABSTRACT Congenital virus infections, for example cytomegalovirus and rubella virus infections, commonly affect the central nervous and hematological systems in fetuses and offspring. However, interactions between emerging congenital Zika virus and hematological system—bone marrow and blood—in fetuses and offspring are mainly unknown. Our overall goal was to determine whether silent in utero Zika virus infection can cause functional and molecular footprints in the bone marrow and blood of fetuses and offspring. We specifically focused on silent fetal infection because delayed health complications in initially asymptomatic offspring were previously demonstrated in animal and human studies. Using a well-established porcine model for Zika virus infection and a set of cellular and molecular experimental tools, we showed that silent in utero infection causes multi-organ inflammation in fetuses and local inflammation in the fetal bone marrow. In utero infection also caused footprints in the offspring bone marrow and PBMCs. These findings should be considered in a broader clinical context because of growing concerns about health sequelae in cohorts of children affected with congenital Zika virus infection in the Americas. Understanding virus-induced molecular mechanisms of immune activation and inflammation in fetuses may provide targets for early in utero interventions. Also, identifying early biomarkers of in utero-acquired immunopathology in offspring may help to alleviate long-term sequelae.
Bias in C iv-based quasar black hole mass scaling relationships from reverberation mapped samples

The masses of the black holes powering quasars represent a fundamental parameter of active galaxies. Estimates of quasar black hole masses using single-epoch spectra are quite uncertain, and require quantitative improvement. We recently identified a correction for C IV $\lambda$1549-based scaling relationships used to estimate quasar black hole masses that relies on the continuum-subtracted peak flux ratio of the ultraviolet emission-line blend Si IV + OIV] (the $\lambda$1400 feature) to that of C IV. This parameter correlates with the suite of associated quasar spectral properties collectively known as "Eigenvector 1" (EV1). Here we use a sample of 85 quasars with quasi-simultaneous optical-ultraviolet spectrophotometry to demonstrate how biases in the average EV1 properties can create systematic biases in C IV-based black hole mass scaling relationships. This effect results in nearly an order of magnitude moving from objects with small $ $, which have overestimated black hole masses, to objects with large $ $, which have underestimated values. We show that existing reverberation-mapped samples of quasars with ultraviolet spectra -- used to calibrate C IV-based scaling relationships -- have significant EV1 biases that result in predictions of black hole masses nearly 50\% too high for the average quasar. We offer corrections and suggestions to account for this bias.
Human vaccines & immunotherapeutics: News October 2022

The European Medicines Agency’s advisory committee has recommended the authorization of the COVID-19 mRNA vaccines BNT162b2 (Pfizer & BioNTech) and mRNA-1273 (Moderna) for use in children aged ≥6 months. Clinical trials have demonstrated the safety and immunogenicity of low-dose formulations in this age group. The US Food and Drug Administration (FDA) has extended the emergency-use authorization of the bivalent Omicron BA.4/BA.5-adapted version of the BNT162b2 vaccine to include children 5–11 y old. The BA.4/BA.5 strains of SARSCoV-2 currently dominate in circulation worldwide. The FDA has also approved a booster dose of the adjuvanted protein subunit vaccine NVX-CoV2373 (Novavax) for adults ≥6 months after the primary course, based on Phase 3 Prevent-19 trial data showing robust immunogenicity. Other COVID-19 vaccines in development include PTXCOVID19-B (Providence Therapeutics), which demonstrated safety and neutralizing antibody immunogenicity non-inferior to BNT162b2 in >500 healthy adults enrolled in the Phase 2 PRO-CL-002 trial, and the VLP vaccine ABNCoV2 (Bavarian Nordic), which restored strong protective immunity lasting at least 6 months as a booster dose following primary vaccination with an mRNA vaccine.
Elevated plasma miR‐210 expression is associated with atypical genitalia in patients with 46,XY differences in sex development

Differences of sex development (DSD) is a term used for conditions in which the chromosomal, gonadal or phenotypical sex is atypical. 46,XY DSD patients frequently present undervirilized external genitalia. The expression of different miRNAs in many organs of the male genital system has been reported, and these miRNAs have been associated with testicular function and its disorders, but no description has been related to DSD conditions. This study aimed to evaluate the plasma expression of miR‐210 in 46,XY DSD patients who presented atypical genitalia at birth.