Miracle-dz/UniFAR-FTUs huggingface dataset:
Scattering-angle-dependent translational energy spectroscopy for electron capture by doubly charged ions

Translational energy spectra dependent on scattering angle have been measured for single-electron capture in the impact of doubly charged ions (Ar2+, Kr2+, Xe2+, impact energies 0.5-5 keV) on He, Ne or Ar. The projectile kinetic energy resolution was better than 1 eV (FWHM), and identification of the various reaction channels was supported by systematic variation of the metastable fractions in the respective primary-ion beams.
Flare Plasma Dynamics Observed with the Yohkoh Bragg Crystal Spectrometer

Using data from the Bragg crystal spectrometer on the Yohkoh spacecraft we have computed measures of the total intensity, centroid position, and line width for the resonance line of Ca XIX during the rise phase and after maximum for 219 solar flares. The difference between the centroid positions early and late in each flare yields a measure of the line-of-sight velocity shift of the line centroid. We find a trend in the average value of the centroid shift with distance from Sun center suggesting radial mass motions with a characteristic velocity of 58 km s −1 . There is a correlation between the rise-phase line widths and the centroid shift
Mueller-matrix Ellipsometry on Electroformed Rough Surfaces

Abstract Automated Mueller-matrix ellipsometry was used to investigate the optical properties of electroformed standard rough surfaces as a function of r.m.s. surface roughness heights and angle of incidence. The r.m.s. roughness of the specimens examined varied from 50 to 12 500 nm. Six different surface finishes and 22 different specimens were examined and Mueller matrices were obtained at angles of incidence that varied from 30 to 80°. Measurements were conducted at a wavelength of 633 nm with the use of a division-of-amplitude photopolarimeter capable of simultaneously measuring all four Stokes parameters of arbitrarily polarized light. Values of ψ and Δ, the ellipsometric parameters, were derived from the measured Mueller matrices. The results demonstrate firstly the monotonic variations in the derived values of Δ with surface roughness for fixed angles of incidence, which include a ‘resonance’ effect for specimens with r.m.s. roughness heights close to the wavelength of light, secondly a systematic .
The temperature structure in accretion flows onto massive protostars

Radiation transfer problems involved in the infall of dust and gas during star formation are studied. Dust properties are discussed, and modifications of spherical radiative transfer equations are presented that permit forward scattering by dust to be treated for the small size of the star relative to the inner radius of the shell. A procedure for deriving the stellar radiation field incident on the inner edge of the shell is developed. The temperature correction procedure of Cassinelli and Hartmann (1975) for extended stellar atmospheres is modified so that the multitemperature nature of the grains in the cloud may be derived. Temperature distributions for three schematic models in which the density is prespecified are discussed. Radiative acceleration of grains is addressed, showing that the proper mean opacity differs by a large factor from the Rosseland mean opacity that is commonly used. Emergent fluxes for the models are given. 56 references.
Queues for a Vehicle-Actuated Traffic Light

A vehicle-actuated traffic light controls two intersecting traffic streams keeping the light green for lane i, i = 1 or 2 until any existing queue has been discharged and a headway of duration at least βi, is detected in the subsequent arrivals. The object of this paper is to investigate how one should choose the βi so as to minimize the average delay per vehicle at the intersection. A model is considered in which the arrival headways are exponentially distributed random variables, departure headways have any specified distribution, and there is a random lost time for each switch of the traffic light. Formulas are derived for the moments of the cycle times, the average wait per vehicle, and the optimal βi.
Proximal algorithms for solving mixed bifunction variational inequalities

In this paper, we suggest and analyze some proximal methods for solving mixed bifunction variational inequalities using the auxiliary principle technique. Convergence of these methods is considered under some mild suitable conditions on the bifunction and the operators. Several cases are also discussed. Results in this paper include some new and known results as special cases. Key words: Bifunction, variational inequality, auxiliary principle technique, proximal point algorithms, convergence.
Single-cell spatial landscape of immunotherapy response reveals mechanisms of CXCL13 enhanced antitumor immunity

Background Immunotherapy has revolutionized clinical outcomes for patients suffering from lung cancer, yet relatively few patients sustain long-term durable responses. Recent studies have demonstrated that the tumor immune microenvironment fosters tumorous heterogeneity and mediates both disease progression and response to immune checkpoint inhibitors (ICI). As such, there is an unmet need to elucidate the spatially defined single-cell landscape of the lung cancer microenvironment to understand the mechanisms of disease progression and identify biomarkers of response to ICI. Methods Here, in this study, we applied imaging mass cytometry to characterize the tumor and immunological landscape of immunotherapy response in non-small cell lung cancer by describing activated cell states, cellular interactions and neighborhoods associated with improved efficacy. We functionally validated our findings using preclinical mouse models of cancer treated with anti-programmed cell death protein-1 (PD-1) immune checkpoint blockade. Results We resolved 114,524 single cells in 27 patients treated with ICI, enabling spatial resolution of immune lineages and activation states with distinct clinical outcomes. We demonstrated that CXCL13 expression is associated with ICI efficacy in patients, and that recombinant CXCL13 potentiates anti-PD-1 response in vivo in association with increased antigen experienced T cell subsets and reduced CCR2+ monocytes. Discussion Our results provide a high-resolution molecular resource and illustrate the importance of major immune lineages as well as their functional substates in understanding the role of the tumor immune microenvironment in response to ICIs.
Characterising airway obstructive, dysanaptic and PRISm phenotypes of prematurity-associated lung disease

Introduction Although obstructive airway disease has been shown to be associated with prematurity, other spirometry phenotypes are less well described. Objectives We characterised abnormal spirometry phenotypes in preterm-born children, including prematurity-associated obstructive lung disease (POLD, forced expiratory volume in 1 s (FEV1)<lower limit of normal (LLN), FEV1/forced vital capacity (FVC)<LLN), prematurity-associated preserved ratio of impaired spirometry (pPRISm, FEV1<LLN, FEV1/FVC≥LLN) and prematurity-associated dysanapsis (pDysanapsis, FEV1≥LLN, FEV1/FVC<LLN), and associated them with early life factors, bronchodilator responsiveness and fractional exhaled nitric oxide (FENO). Methods 768 children, aged 7–12 years, underwent FENO measurements and spirometry before and after salbutamol. Groups were compared using parametric tests; multinomial regression was used. Results 22.6% of 544 preterm-born (mean gestation: 31 weeks) and 9.2% of 195 term-born children, with satisfactory data available, were classified into one of four abnormal spirometry groups. Each phenotype was generally more prevalent in preterm-born children than in the term-born children. For the preterm group, POLD-reversible (4.4%) was associated with increased FENO, bronchopulmonary dysplasia (BPD) and intrauterine growth restriction. POLD-fixed group (3.3%) did not have increased FENO but was associated with BPD. 41% of the pDysanapsis group (5.9%) had bronchodilator response, 31% had increased FENO and was associated with postnatal weight gain. In the pPRISm group (9%), 13% responded to bronchodilators, FENO was not increased and was non-significantly associated with body mass index (p=0.064). Conclusions Further to airway obstruction, we describe airway dysanapsis and pPRISm spirometry phenotypes in survivors of prematurity, both of which have poor outlook in other disease groups. By identifying specific phenotypes, targeted therapy can be developed to improve long-term outcomes.
Prioritizing choice and assent in the assessment and treatment of food selectivity

Food selectivity affects up to 72% and 45% of individuals with and without disabilities, respectively, and there is a need for interventions that rely on positive, unrestrictive strategies. We evaluated an assessment and treatment package for food selectivity for young children with developmental disabilities that prioritized caregiver collaboration, client autonomy, and did not rely on restrictive procedures (e.g. escape extinction). The process involved: (a) collaborating with caregivers on the selection of foods and design of the children’s functional analyses; (b) indirectly and directly measuring food preferences prior to treatment; (c) evaluating the sensitivity of mealtime problem behavior to environmental variables through an interview-informed synthesized contingency analysis (IISCA); and (c) incorporating the assessment results into a progressive treatment process consisting of choice-making opportunities and differential reinforcement of successive approximations to consumption. Children also had the ability to opt in and out of treatment sessions. The treatment was effective in increasing consumption of nonpreferred foods and successfully extended to caregivers. Practical implications and directions for future research are discussed.
‘Stakeholders are almost always resistant’: Australian behaviour support practitioners’ perceptions of the barriers and enablers to reducing restrictive practices

A restrictive practice (RP) is defined as a practice or intervention that has the effect of restricting the rights or freedom of movement of a person, and includes physical, mechanical, and chemical restraint, and seclusion. If misused or overused, RPs may present serious human rights infringements. In Australia, behaviour support practitioners who deliver behaviour support funded by the National Disability Insurance Scheme are responsible for developing positive behaviour support plans that aim to reduce and eliminate the use of RPs. At present, little is known about the barriers that behaviour support practitioners experience when attempting to reduce and eliminate the use of RPs and, conversely, what helps (or enables) them to reduce and eliminate RPs. To learn more, we conducted an online survey consisting of two open-ended questions with 109 Australian behaviour support practitioners to identify barriers and enablers. We found that fear and reluctance on the part of stakeholders were often barriers to reducing the use of RPs. However, we found that having time, funding, and resources for training, supervision, other implementation activities, care team collaboration, and data-based decision-making helped overcome barriers. We provide specific recommendations for addressing identified barriers for individual behaviour support practitioners, service provider organisations, and government and regulatory agencies.
Computational Aerothermodynamic Simulation Issues on Unstructured Grids

*† The synthesis of physical models for gas chemistry and turbulence from the structured grid codes LAURA and VULCAN into the unstructured grid code FUN3D is described. A directionally Symmetric, Total Variation Diminishing (STVD) algorithm and an entropy fix (eigenvalue limiter) keyed to local cell Reynolds number are introduced to improve solution quality for hypersonic aeroheating applications. A simple grid-adaptation procedure is incorporated within the flow solver. Simulations of flow over an ellipsoid (perfect gas, inviscid), Shuttle Orbiter (viscous, chemical nonequilibrium) and comparisons to the structured grid solvers LAURA (cylinder, Shuttle Orbiter) and VULCAN (flat plate) are presented to show current capabilities. The quality of heating in 3D stagnation regions is very sensitive to algorithm options – in general, high aspect ratio tetrahedral elements complicate the simulation of high Reynolds number, viscous flow as compared to locally structured meshes aligned with the flow.
Human resources and innovation capability: Evidences from Nigeria food and beverage firms

Human resources are recognized as the ultimate and most indispensable resource in economic development. In this study, an inquiry was made to ascertain the determinants of workers’ innovativeness. A survey of 229 respondents in food and beverage processing firms selected through random and snowballing sampling techniques was implemented. Data were analyzed using exploratory factor analysis, confirmatory factor analysis and the structural equation model. Findings reveal that though personal, family, organizational and social factors were hypothesized to be influencing the ability of employees to innovate, only family (β = 0.358; p < 0.001) and organizational (β = 0.213; p < 0.01) factors showed a significant and positive influence on employees’ innovativeness. The paper concludes that the support employees received from their homes and organizations is crucial and contributed significantly to their innovative ability.
Clustering and hotel room prices in Dubai

In this article, we study the influence of the room properties, hotel amenities, hotel location, and, more importantly, the characteristics of hotels in the surrounding area on the prices of hotel rooms. The effects of different determinants are estimated using the hedonic price model for a cross-section of 250 hotels in Dubai. In addition to the typical characteristics of hotels and hotel rooms such as hotel amenities, star rating, and room size, we include location-specific characteristics such as accessibility to public transportation, airport, and, more importantly, clustering variables to capture the effects of local competition and spillovers from surrounding hotels. Our results indicate significant and strong effects of accessibility to attractions, transportation, hotel’s star rating, and room size, as expected. Our estimations also indicate that local competition reduces the room price, and local quality spillover increases the room price, and both effects are predominantly limited to the hotel’s immediate surroundings. Our estimations indicate that having one more hotel in the immediate surroundings decreases the room price by about one percent, and an increase in the average quality of the hotels in the immediate surroundings by one star rating increases the room price by more than 20%.
Compressibility of Osteochondral Autograft Transfer Donor Grafts: A Comparison of Different Donor Regions and How Much Shortening Occurs of Plugs After Impaction

Background: Osteochondral autograft transfer (OAT) is a useful technique for full-thickness cartilage lesions of the distal femur. Various techniques recommend harvesting a plug 2 mm longer than the recipient hole to allow for graft impaction. Grafts with limited compressibility may not sit flush when impacted. Purpose: To compare the compressibility/shortening of OAT donor plug regions from the distal femur of human cadaveric knees after impaction. Study Design: Controlled laboratory study. Methods: A total of 20 cadaveric knees (mean age, 70.3 ± 8.4 years) were divided into 4 donor regions: medial intercondylar (IC) notch, lateral IC notch, medial trochlea, and lateral trochlea. Each region was subdivided into 4 zones: far superior (FSZ), middle superior (MSZ), middle inferior (MIZ), and far inferior (FIZ). A total of 320 grafts (6-mm diameter, 15-mm depth) were extracted, and a custom-built machine was used to strike the graft 5 times using a predetermined energy of 0.11 J. The graft length was measured initially and after each impact. Statistical analysis of the compressibility for each of the 4 regions and all 16 zones was performed utilizing analysis of variance, with post hoc testing using the Fisher’s least significant difference. Results: Compression in the lateral IC notch, medial IC notch, medial trochlea, and lateral trochlea was 2.4 ± 1.5, 2.1 ± 0.7, 3.1 ± 2.2, and 2.1 ± 0.6 mm, respectively, with significant differences between the 4 regions (P < .01) and the most compression in the medial trochlea (P < .01). Subgroup analysis showed that the lateral trochlea had higher compressibility for FIZ versus MIZ (P = .02) and the lateral IC notch had higher compressibility for FSZ versus FIZ and MIZ (P < .05 for both). Conclusion: Compressibility varied between OAT donor sites in the distal femur. OAT donor grafts showed the highest compressibility in the medial trochlea (3.1 mm) and lateral IC notch FSZ (3.0 mm). Clinical Relevance: The lateral trochlea, medial IC notch, and the lower zones of the lateral IC notch grafts should not be oversized more than 2 mm in length, as these grafts may not compress adequately.
Exploring differential bundle functioning in mathematics by gender: the effect of hierarchical modelling

Researchers interested in exploring substantive group differences are increasingly attending to bundles of items (or testlets): the aim is to understand how gender differences, for instance, are explained by differential performances on different types or bundles of items, hence differential bundle functioning (DBF). Some previous work has modelled hierarchies in data in this context or considered item responses within persons, but here we model the bundles themselves as explanatory variables at the item level potentially explaining significant intra-class correlation due to gender differences in item difficulty, and thus explaining variation at the second item level. In this study, we analyse DBF using single- and two-level models (the latter modelling random item effects, which models responses at Level 1 and items at Level 2) in a high-stakes National Mathematics test. The models show comparable regression coefficients but the statistical significances of the two-level models are smaller due to the larger values of the estimated standard errors. We discuss the contrasting relevance of this effect for test developers and gender researchers.
Factors That Affect Return to Sports After an Achilles Tendon Rupture: A Qualitative Content Analysis

Background: Achilles tendon rupture is common among physically active individuals, yet a high percentage fail to return to their former activity after the injury. Quantifiable factors such as type of treatment, hours of rehabilitation, and age have not been associated with return-to-play rates. A factor that influences recovery is the participant’s experience before and throughout the rehabilitation process, which can be explored using a qualitative content analysis. Purpose: To explore and describe what influences the participant to return to physical activity after an Achilles tendon rupture. Study Design: Cross-sectional study; Level of evidence, 3. Methods: Twenty participants (14 men; mean age, 46 years) were interviewed as part of this study. All participants had ruptured their Achilles tendon 4 to 6 years before the interviews. From the interviews, codes were extracted that evolved into 19 subcategories, 6 categories, and 1 theme. Results: The overarching theme that emerged was “Help me and then I can fix this. ” The 6 categories were (1) one’s own drive to succeed, (2) having a supportive social network, (3) trusting the support from the health and social systems, (4) receiving and adapting information from others drives persistence in returning to activity, (5) impact of the injury on psychological factors; and (6) influence of physiological aspects. Conclusion: To be able to recover properly from an Achilles tendon rupture and return to activity, the study participants described the importance of obtaining the support needed to be able to gain optimal rehabilitation. In the participants’ opinion, for a greater chance of successful treatment and rehabilitation, it was vital to be provided with good support.
Duck pan-genome reveals two transposon-derived structural variations caused bodyweight enlarging and white plumage phenotype formation during evolution

Structural variations (SVs) are a major source of domestication and improvement traits, however SV profiles of duck and their phenotypic impacts largely hidden. We present the first duck pan-genome constructed using five genome assemblies capturing ∼40.98 Mb new sequences. This pan-genome together with high-depth sequencing data (∼46.5X) identified 101,041 SVs, of which substantial proportions were derived from transposable element (TE) activity. Many TE-derived SVs anchoring in a gene body or regulatory region are linked to duck’s domestication and improvement. By combining quantitative genetics with molecular experiments, we dissect how TE-derived SVs change gene expression of IGF2BP1 and generate a novel transcript of MITF, shaping bodyweight and white plumage. In the IGF2BP1 locus, the TE-derived SV explains the largest effect on bodyweight among avian species (27.61% of phenotypic variation). Our findings highlight the importance of using a pan-genome as a reference in genomics studies and explore the roles of TE-derived SVs in trait formation and in livestock breeding.
Distribution modeling quantifies collective TH cell decision circuits in chronic inflammation

Immune responses are tightly regulated by a diverse set of interacting immune cell populations. Alongside decision-making processes such as differentiation into specific effector cell types, immune cells initiate proliferation at the beginning of an inflammation, forming two layers of complexity. Here, we developed a general mathematical framework for the data-driven analysis of collective immune-cell dynamics. We identified qualitative and quantitative properties of generic network motifs, and we specified differentiation dynamics by analysis of kinetic transcriptome data. Further, we derived a specific, data-driven mathematical model for Th1 vs. Tfh cell fate-decision dynamics in acute and chronic LCMV infections in mice. The model recapitulates important dynamical properties without model fitting, and solely by employing measured response-time distributions. Model simulations predict different windows of opportunity for perturbation in acute and chronic infection scenarios, with potential implications for optimization of targeted immunotherapy.
Corporate governance, market conditions and investors’ reaction to information signals

We examine and compare the extent to which the reaction of investors to earnings announcements is influenced by a firm’s governance profile and prevailing market conditions. We find that firms with better governance characteristics experience a larger initial reaction to both good and bad earnings announcements regardless of the prevailing sentiment and uncertainty conditions. However, the influence of governance is constrained to the announcement period. We demonstrate that changes in market uncertainty and/or investor sentiment are related to the post-earnings announcement drift. We also find that a major channel through which greater corporate governance influences the market response to unexpected earnings news is by lowering information uncertainty and so providing greater clarity of the implication of the news for firm value. Finally, we establish that two types of uncertainties (market and information) have very different influence on investor’s response to information signals. JEL Classification: D81, G10, G14, G30, G32