Miracle-dz/UniFAR-FTUs huggingface dataset:
Using Submaximal Exercise Heart Rate for Monitoring Cardiorespiratory Fitness Changes in Professional Soccer Players: A Replication Study.

PURPOSE To assess the value of monitoring changes in fitness in professional soccer players, using changes in heart rate at submaximal intensity (HR12km/h) over the velocity at a lactate concentration of 4 mmol/L (v4mmol/L). The authors reexamined (1) a range of threshold magnitudes, which may improve detecting substantial individual changes and (2) the agreement between changes in these 2 variables. METHODS On at least 2 occasions during different moments of the season, 97 professional soccer players from Germany (first, second, and fourth division) completed an incremental test to determine HR12km/h and v4mmol/L. Optimal thresholds for changes in HR12km/h and v4mmol/L were assessed, using various methods (eg, smallest worthwhile change + typical error [TE], successive reiterations approach). Agreement between both variable changes was examined for the whole sample (225 comparisons), 4 different subgroups (depending on the moment of the season), and in an individual over 6 years (n = 23 tests). RESULTS Changes of 4.5% and 6.0% for HR12km/h and v4mmol/L, respectively, were rated as optimal to indicate substantial changes in fitness. Depending on the (sub)groups analyzed, these thresholds yielded 0% to 2% full mismatches, 22% to 38% partial agreements, and 60% to 78% full agreements in terms of fitness change interpretation between both variables. CONCLUSIONS When lactate sampling during incremental tests is not possible, practitioners willing to monitor adult professional soccer players' (Germany; first, second, and fourth division) training status can confidently implement short, 3-minute submaximal runs, with 4.5% changes in HR12km/h being indicative of true substantial fitness changes, with 60% to 78% accuracy. Future studies should investigate the potential role of confounding factors of HR12km/h to improve changes in fitness prediction.
Evaluation of a Multiethnic Polygenic Risk Score Model for Prostate Cancer

Abstract Polygenic risk scores (PRSs) of common genetic variants have shown promise in prostate cancer risk stratification, but their validity across populations has yet to be confirmed. We evaluated a multiethnic PRS model based on 269 germline genetic risk variants (261 were available for analysis) using an independent population of 13 628 US men. The PRS was strongly associated with prostate cancer but not with any other disease. Comparing men in the top PRS decile with those at average risk (40%-60%), the odds ratio of prostate cancer was 3.89 (95% confidence interval = 3.24 to 4.68) for men of European ancestry and 3.81 (95% confidence interval = 1.48 to 10.19) for men of African ancestry. By age 85 years, the cumulative incidence of prostate cancer for European American men was 7.1% in the bottom decile and 54.1% in the top decile. This suggests that the PRS can be used to identify a substantial proportion of men at high risk for prostate cancer.
The association of mental health with positive behaviours, attitudes and virtues in community-dwelling older adults: Results of a population-based study

Background: Despite major advancements in understanding of the factors associated with mental health in older adults, studies assessing positive behaviours, attitudes and virtues are still scarce in the literature. Aims: This study aims to investigate whether factors related to positive behaviours, attitudes and virtues are associated with mental health (i.e. depression, anxiety and stress) and satisfaction with life in Brazilian community-dwelling older adults. Methods: A population-based, cross-sectional study of Brazilian older adults who were users of the public health system and seen by Family Health teams was conducted in 2017. Instruments were applied to assess cognition, physical activity, sleep, quality of life, social support, religiousness, spirituality, satisfaction with life, resilience, altruism, volunteerism, loneliness, meaning in life and mental health (i.e. depression, anxiety and stress). Analyses were carried out using linear and logistic regression models. Results: A total of 534 (93.5%) older adults were included. Positive behavioural factors and values including volunteerism, meaning in life, resilience, peace, loneliness, faith and religiousness were associated with mental health outcomes (i.e. depression, anxiety and stress), as were traditional factors, such as sleep, gender, social support and cognitive state. Conclusions: Aspects related to positive behaviour, attitudes and virtues can impact the mental health of the older population. These results can serve to alert health professionals on the importance of addressing these factors and help guide the implementation of preventive measures and interventions for this age group.
Chronic peptide-based GIP receptor inhibition exhibits modest glucose metabolic changes in mice when administered either alone or combined with GLP-1 agonism

Combinatorial gut hormone therapy is one of the more promising strategies for identifying improved treatments for metabolic disease. Many approaches combine the established benefits of glucagon-like peptide-1 (GLP-1) agonism with one or more additional molecules with the aim of improving metabolic outcomes. Recent attention has been drawn to the glucose-dependent insulinotropic polypeptide (GIP) system due to compelling pre-clinical evidence describing the metabolic benefits of antagonising the GIP receptor (GIPR). We rationalised that benefit might be accrued from combining GIPR antagonism with GLP-1 agonism. Two GIPR peptide antagonists, GIPA-1 (mouse GIP(3–30)NH2) and GIPA-2 (NαAc-K10[γEγE-C16]-Arg18-hGIP(5–42)), were pharmacologically characterised and both exhibited potent antagonist properties. Acute in vivo administration of GIPA-1 during an oral glucose tolerance test (OGTT) had negligible effects on glucose tolerance and insulin in lean mice. In contrast, GIPA-2 impaired glucose tolerance and attenuated circulating insulin levels. A mouse model of diet-induced obesity (DIO) was used to investigate the potential metabolic benefits of chronic dosing of each antagonist, alone or in combination with liraglutide. Chronic administration studies showed expected effects of liraglutide, lowering food intake, body weight, fasting blood glucose and plasma insulin concentrations while improving glucose sensitivity, whereas delivery of either GIPR antagonist alone had negligible effects on these parameters. Interestingly, chronic dual therapy augmented insulin sensitizing effects and lowered plasma triglycerides and free-fatty acids, with more notable effects observed with GIPA-1 compared to GIPA-2. Thus, the co-administration of both a GIPR antagonist with a GLP1 agonist uncovers interesting beneficial effects on measures of insulin sensitivity, circulating lipids and certain adipose stores that seem influenced by the degree or nature of GIP receptor antagonism.
Statistical profiling reveals correlations between the cell response to and the primary structure of Rho‐GAPs

Rho‐GTPase‐activating proteins (Rho‐GAPs) are essential upstream regulators of the Rho family of GTPases. Currently, it remains unclear if the phenotypic change caused by perturbations to a Rho‐GAP is predictable from its amino acid sequence. Here we analyze the relationship between the morphological response of cells to the silencing of Rho‐GAPs and their primary structure. For all possible pairs of 57 different Rho‐GAPs expressed in MCF10A epithelial cells, the similarity in the Rho‐GAP silencing‐induced morphological change was quantified and compared to the similarity in the primary structure of the corresponding pairs. We found a distinct correlation between the morphological and sequence similarities in a specific group of RhoA‐targeting Rho‐GAPs. Thus, the family‐wide analysis revealed a common feature shared by the specific Rho‐GAPs.
Time and space catch up with restoration programs that ignore ecosystem service trade-offs

Ambitious investments in expanding forest cover globally need more careful analysis to avoid severe unintended consequences. In response to extreme societal consequences of ecosystem degradation and climate change, attention to ecological restoration is increasing globally. In China, investments in restoration exceeded USD 378.5 billion over the past decade. However, restoration programs are experiments that can cause marked unintended consequences, with trade-offs across space and time that have undergone little empirical examination. We quantified the long-term effects of large-scale afforestation for soil erosion and sandstorm prevention in semiarid China. We found that soil erosion was notably reduced by afforestation but surface runoff declined significantly, after a time lag of 18 years, limiting overall benefit. While forest area also increased, forest quality declined, interacting with reduced surface water runoff. Crucially, increased forest water consumption accelerated downstream groundwater depletion, thus intensifying conflicts over water use. The time lags and spatial trade-offs revealed by this case study provide critical lessons for large-scale restoration programs globally.
Phytochemicals in breast milk and their benefits for infants

Abstract Exclusive breastfeeding is widely recommended at least during the first 6 months of life and breast milk (BM) composition depends on maternal diet. Phytochemicals, including polyphenols and carotenoids, are recognized by their powerful antioxidant activities being present in BM. This review provides an overview of BM composition with respect to polyphenols and carotenoids evaluating its possible benefits for the infant. Polyphenols do not have any body deposit and their content in BM depends on regular dietary intake from mothers and bioavailability of them, while carotenoids content in BM changed depending on factors including stages of breastfeeding, maternal diet and maternal health status. Preeclampsia, overweight or obesity are conditions able to reduce polyphenols and carotenoids in BM by using them as antioxidants. For both polyphenols and carotenoids, the supplementation slightly enhances their BM content. Few studies have shown the presence of phytochemicals in infant plasma and still remains unclear the benefits that polyphenols and carotenoids provide for development of infants. Further studies using long-term, randomized and controlled designs are necessary to determine the relation between carotenoids, polyphenols and its potential benefits for early childhood.
Factors that influence performance in Olympic air-rifle and small-bore shooting: A systematic review

Background Air-rifle and small-bore shooting are fascinating Olympic sports due to their unique performance requirements for accuracy and precision. Objective The purpose of our study was to systematically research the literature to determine and summarize performance determinants in both air-rifle and small-bore shooting. Since some athletes participate internationally in both disciplines in competition, the disciplines must have some similarity in the performance structure. Therefore, we further investigated whether performance in air-rifle and small-bore shooting can be explained by the same performance determinants. Methods We systematically searched in four databases using combined keywords relevant to performance in air-rifle and small-bore shooting. The articles included had undergone peer-review and had a) a direct relation to shooting performance, b) an indirect relation by comparing the performance of shooters of different skill levels, and c) a practical relevance (directly controllable through training). After the quality of each article was assessed, the key data were extracted and summarized. Results The fourteen articles included achieved an average of 60 ± 14% (range 30–80%) in quality assessment. Altogether, articles covered 268 subjects (32% female), of which 19% were elite- and 28% were national-level athletes. Sixteen performance determinants were investigated, which were divided into anthropometric, technical-coordinative, physiological and psychological categories. Both in air-rifle and small-bore shooting, rifle stability and body sway were found to differ between elite- and national-level athletes. In both disciplines, body sway seemed to have no influence on shot score in elite- and national-level athletes. Similarly, heart rate did not correlate with shot score at nearly all performance levels in both disciplines. In national-level air-rifle athletes, horizontal rifle stability, aiming accuracy and aiming time were found to affect shot score. Conclusions To be competitive at a national-level in air-rifle shooting, a highly developed aiming process is needed to achieve a high shot score. Lack of data prevented us from drawing evidence-based conclusions in elite-level air-rifle athletes and in small-bore shooting. Future research should investigate possible performance determinants both in air-rifle and in small-bore shooting, especially with elite-level athletes, to confirm or disprove existing findings. Further research should use more complex analyses to investigate the multifaceted processes associated with different performance determinants.
Urban index and lifestyle risk factors for cardiovascular diseases in China: A cross-sectional study

China is at a stage of rapid urbanization over the past decades, and the association of urbanization with cardiovascular disease has been confirmed by previous studies. However, few studies assessed the association of urbanization with cardiovascular risk factors, especially in Chinese population. We conducted a cross-sectional, populational-based study, using data from China Health and Nutrition Survey (CHNS) in 2009. The logistic regression was used to assess the association of urbanization measured by urban index with cardiovascular risk factors (diabetes mellitus, hypertension, dyslipidemia, obesity, smoking, physical activity and fruits and vegetables consumption), varied with sex. The current study included 18,887 participants enrolled (mean age 39.8 ± 19.8 years; 52.2% female) who live in China. In regression model, the urban index was significantly associated with the variations of cardiovascular risk factors for male, including diabetes (OR 1.34, 95% CI: 1.22–1.48), hypercholesterolemia (OR 1.15, 95% CI: 1.09–1.22), never smoking (OR 0.92, 95% CI: 0.89–0.96), higher fruits and vegetables consumptions (OR 0.93, 95% CI: 0.87–0.99), higher body mass index (BMI) (OR 1.16, 95% CI: 1.10–1.22), and higher physical activity (OR 0.69, 95% CI: 0.66–0.73). Compared with the male, the associations of urban index with cardiovascular risk factors for female were similar, but not for BMI (OR 1.00, 95% CI: 0.96–1.05). The present finding emphasizes the changes of cardiovascular risk factors associated with urbanization in China, and indicated that close attention should be paid to the risk of hypercholesterolemia, diabetes and men’s obesity in the process of urbanization.
Psychometric properties of the Turkish version of L'Insalata Shoulder Rating Questionnaire

Abstract Purpose The aim of this study was to examine the psychometric properties of the culturally adapted Turkish version of the L’Insalata Shoulder Rating Questionnaire (TrLSRQ). Materials and methods Comprehensibility and content validity of the TrLSRQ were tested on 14 patients and seven physiotherapists, respectively. Subsequently, 90 volunteer patients with shoulder pain completed the TrLSRQ twice within a week for test–retest analysis. Correlations with Shoulder Pain and Disability Index (SPADI), Oxford Shoulder Score (OSS), Penn Shoulder Score (PSS), and Upper Extremity Functional Index (UEFI) were used to assess convergent validity; and pain intensity and active range of shoulder motions were measured to assess criterion validity. Results Content validity index of the TrLSRQ was 0.99. The internal consistency was high (Cronbach’s α = 0.89); and item-total correlations were 0.37–0.74. In test–retest analysis, ICC values were 0.65–0.95 for all items; and 0.86–0.94 for the subcategories. The TrLSRQ scores were positively correlated with UEFI, and negatively correlated with other scales (p < 0.05). Its correlations with the intensity of pain and shoulder range of motions (p < 0.05) indicated that the questionnaire had good criterion validity. Conclusions The TrLSRQ is a reliable and valid measure to assess pain, activities of daily living, sports/recreation, and work in patients with shoulder pain. Implications for Rehabilitation Patient-reported outcome measures (PROMs) are important tools to assess the impact of health problems on overall well-being of the patients. The Turkish version of the L’Insalata Shoulder Rating Questionnaire (TrLSRQ) is a PROM that evaluates the impact of shoulder problems on patient's pain, daily activities, sportive/recreational activities, and work; as well as overall satisfaction with his/her shoulder, and ranking of areas in which the patient likes to see improvement. The TrLSRQ scores are well correlated with other relevant PROMs, as well as with the intensity of pain and shoulder range of motions. The TrLSRQ is a reliable and valid measure, which can be used for both clinical and research purposes to evaluate symptoms and functional status of patients with shoulder pain.
Significant Pain Reduction in Hospitalized Patients Receiving Integrative Medicine Interventions by Clinical Population and Accounting for Pain Medication.

Background: Prior research has reported that integrative medicine (IM) therapies reduce pain in inpatients, but without controlling for important variables. Here, the authors extend prior research by assessing pain reduction while accounting for each patient's pain medication status and clinical population. Methods: The initial data set consisted of 7,106 inpatient admissions, aged ≥18 years, between July 16, 2012, and December 15, 2014. Patients' electronic health records were used to obtain data on demographic, clinical measures, and pain medication status during IM. Results: The final data set included first IM therapies delivered during 3,635 admissions. Unadjusted average pre-IM pain was 5.33 (95% confidence interval [CI]: 5.26 to 5.41) and post-IM pain was 3.31 (95% CI: 3.23 to 3.40) on a 0-10 scale. Pain change adjusted for severity of illness, clinical population, sex, treatment, and pain medication status during IM was significant and clinically meaningful with an average reduction of -1.97 points (95% CI: -2.06 to -1.86) following IM. Adjusted average pain was reduced in all clinical populations, with largest and smallest pain reductions in maternity care (-2.34 points [95% CI: -2.56 to -2.14]) and orthopedic (-1.71 points [95% CI: -1.98 to -1.44]) populations. Pain medication status did not have a statistically significant association on pain change. Decreases were observed regardless of whether patients were taking narcotic medications and/or nonsteroidal anti-inflammatory drugs versus no pain medications. Conclusions: For the first time, inpatients receiving IM reported significant and clinically meaningful pain reductions during a first IM session while accounting for pain medications and across clinical populations. Future implementation research should be conducted to optimize identification/referral/delivery of IM therapies within hospitals. Clinical Trials.gov #NCT02190240.
Methane production and its fate in paddy fields VII. Electron acceptors responsible for anaerobic methane oxidation

Abstract Effects of electron acceptors on anaerobic methane oxidation in paddy fields were investigated using a soil column. Leachate was collected periodically from the bottom of the soil column and incubated together with electron acceptors (NO3 −, MnO2 , Fe(OH)3, SO4 2−) and methane. Application of N03 − and So4 2− resulted in increase of the inorganic carbon content, indicating that the activities of denitrifiers and sulfate reducers were stimulated. Methane content in the leachate decreased by the addition of MnO2 and SO4 2- after incubation. The amount of methane in the leachate decreased by percolation in the plow layer soil or subsoil treated with sulfurous compounds such as CaSO4, FeSO4 , and elemental sulfur. These results suggested that the anaerobic oxidation of methane was associated with sulfate reduction. Analysis of SO4 2− content in the leachate showed that sufficient amounts of SO4 2− for anaerobic methane oxidation in the subsoil were leached from the plow layer soil.
Sport-to-School Spillover Effects of Passion for Sport: The Role of Identity in Academic Performance

There is a theoretical and empirical basis that suggests that passion and identity are interrelated and that they can cross the achievement domain in influencing outcomes. Using a sample of student-athletes (N = 187), the first purpose of this study was to examine whether academic identity and athletic variables (athletic identity, harmonious and obsessive passion for sport) can predict academic performance and persistence. The second purpose was to determine whether these relationships are invariant across sex and first-generation status. Academic outcomes were positively predicted by academic identity and negatively predicted by athletic identity. Harmonious and obsessive passion for sport were both negatively related to academic performance indirectly through athletic identity. Harmonious passion also was a weak positive predictor of academic persistence. The identified relationships were largely invariant across sex and first-generation status. Findings suggest that both academic and athletic variables can predict academic outcomes.
Size and shape of potato tubers

Potatoes are little known products of Iran; yet they are comparaible in size, shape, and substance to any other potato in the world. They are, moreover, considerably cheaper than those grown in the Western Europe, North America, and Austra- lasia. In this study, physical properties of four common varieties of Iranian grown potatoes were determined. These physical proper- ties included physical dimensions, mass, volume, geometric mean diameter, sphericity, aspect ratio, a/b+c, and projected areas. The aforementioned parameters were obtained from individual varie- ties of potatoes as well as a mixture of varieties. In this study, rela- tionships among these physical attributes were determined and a high correlation was found between volume and the diameters of mixed potatoes with a coefficient of determination, R 2 = 0.98, as shown in the equation ln V= 1.2 ln a + 0.94 ln b + 0.86 ln c - 7.28. Mass and volume of the mixed potatoes had a very high coefficient of determination, R 2 = 0.994, as shown in the equation: M = 0.93V- 0.6. A coefficient of determination, R 2 , between an average projec- ted areas (criterion area, Ac) and the measured volume of potatoes was very high, close to one and a nonlinear regression equation for the mixed varieties of potatoes was determined as: Ac = 1.1V 0.71 with R 2 = 0.993. This trend follows the same trend as shown in