Miracle-dz/UniFAR-FTUs huggingface dataset:
Application of SIM, HSPIV, BTM, and BIV Techniques for Evaluations of a Two-Phase Air–Water Chute Aerator Flow

Four image-based techniques—i.e., shadowgraphic image method (SIM), high-speed particle image velocimetry (HSPIV), bubble tracking method (BTM), and bubble image velocimetry (BIV)—are employed to investigate an aerator flow on a chute with a 17° inclination angle. The study focuses on their applications to the following issues: (1) to explore the characteristic positions of three water–air interfaces; (2) to interpret the evolution process of air bubbles shed from the wedged tip of the air cavity; (3) to identify the probabilistic means for characteristic positions near the fluctuating free surface; (4) to explore the probability distribution of intermittent appearance of air bubbles in the flow; (5) to obtain the mean streamwise and transverse velocity distributions of the water stream; (6) to acquire velocity fields, both instantaneous and mean, of air bubbles; (7) to construct a two-phase mean velocity field of both water flow and air-bubbles; and (8) to correlate the relationship among the probability distribution of air bubbles, the mean streamwise and transverse velocity profiles of air bubbles, and water stream. The combination of these techniques contributes to a better understanding of two-phase flow characteristics of the chute aerator.
Virtual reality (VR)-based community living skills training for people with acquired brain injury: A pilot study

Primary objective: The purpose of the present study was to test the usability and effectiveness of a newly-developed virtual reality (VR)-based community living skills training program for people with acquired brain injury (ABI). Method: A small-sample, pre- and post-quasi experimental design was adopted to initially study the efficacy of the VR-based training program. Its usability was also investigated through interviewing subjects. Outcomes were documented in terms of subjects’ skills acquisition, self-efficacy in applying the learnt skills and the transfer ratio of the learnt skills to the real environment. Global cognitive ability and the functional independence level were also assessed. Results: Four subjects with ABI (one traumatic brain injury and three stroke subjects) were successfully recruited and received 10 sessions of VR-based community living skills training. All four subjects showed improvement in skills acquisition and memory performance, while three out of four also showed improvement in self-efficacy and demonstrated transfer of skills to the real environment. Usability was initially supported. Conclusions: Preliminary results suggested positive changes in ABI subjects. The proposed virtual reality (VR) community living skills training software will be further investigated in a randomized controlled trial.
Real-Time Scalable Cortical Computing at 46 Giga-Synaptic OPS/Watt with ~100× Speedup in Time-to-Solution and ~100,000× Reduction in Energy-to-Solution

Drawing on neuroscience, we have developed a parallel, event-driven kernel for neurosynaptic computation, that is efficient with respect to computation, memory, and communication. Building on the previously demonstrated highly optimized software expression of the kernel, here, we demonstrate True North, a co-designed silicon expression of the kernel. True North achieves five orders of magnitude reduction in energy to-solution and two orders of magnitude speedup in time-to solution, when running computer vision applications and complex recurrent neural network simulations. Breaking path with the von Neumann architecture, True North is a 4,096 core, 1 million neuron, and 256 million synapse brain-inspired neurosynaptic processor, that consumes 65mW of power running at real-time and delivers performance of 46 Giga-Synaptic OPS/Watt. We demonstrate seamless tiling of True North chips into arrays, forming a foundation for cortex-like scalability. True North's unprecedented time-to-solution, energy-to-solution, size, scalability, and performance combined with the underlying flexibility of the kernel enable a broad range of cognitive applications.
Low complexity bit parallel architectures for polynomial basis multiplication over GF(2m)

Representing the field elements with respect to the polynomial (or standard) basis, we consider bit parallel architectures for multiplication over the finite field GF(2m). In this effect, first we derive a new formulation for polynomial basis multiplication in terms of the reduction matrix Q. The main advantage of this new formulation is that it can be used with any field defining irreducible polynomial. Using this formulation, we then develop a generalized architecture for the multiplier and analyze the time and gate complexities of the proposed multiplier as a function of degree m and the reduction matrix Q. To the best of our knowledge, this is the first time that these complexities are given in terms of Q. Unlike most other articles on bit parallel finite field multipliers, here we also consider the number of signals to be routed in hardware implementation and we show that, compared to the well-known Mastrovito's multiplier, the proposed architecture has fewer routed signals. The proposed generalized architecture is further optimized for three special types of polynomials, namely, equally spaced polynomials, trinomials, and pentanomials. We have obtained explicit formulas and complexities of the multipliers for these three special irreducible polynomials. This makes it very easy for a designer to implement the proposed multipliers using hardware description languages like VHDL and Verilog with minimum knowledge of finite field arithmetic.
On the design of Robust tube-based MPC for tracking

Abstract This paper deals with the design procedure of the recently presented robust MPC for tracking of constrained linear systems with additive disturbances. This controller is based on nominal predictions and it is capable to steer the nominal predicted trajectory to any target admissible steady state, that is retaining feasibility under any set point change. By means of the notion of tube of trajectories, robust stability and convergence is achieved. The controller formulation has some parameters which provides extra degrees of freedom to the design procedure of the predictive controller. These allow to deal with control objectives such as disturbance rejection, output offset prioritization or enlargement of the domain of attraction. In this paper, output prioritization method, LMI based design procedures and algorithms for the calculation of invariant sets are presented. The proposed enhanced design of the MPC is demonstrated by an illustrative example.
Adenovirus Recruits Dynein by an Evolutionary Novel Mechanism Involving Direct Binding to pH-Primed Hexon

Following receptor-mediated uptake into endocytic vesicles and escape from the endosome, adenovirus is transported by cytoplasmic dynein along microtubules to the perinuclear region of the cell. How motor proteins are recruited to viruses for their own use has begun to be investigated only recently. We review here the evidence for a role for dynein and other motor proteins in adenovirus infectivity. We also discuss the implications of recent studies on the mechanism of dynein recruitment to adenovirus for understanding the relationship between pathogenic and physiological cargo recruitment and for the evolutionary origins of dynein-mediated adenovirus transport.
Preoperative prognostic classification system for hemispheric low-grade gliomas in adults.

OBJECT Hemispheric low-grade gliomas (LGGs) have an unpredictable progression and overall survival (OS) profile. As a result, the objective in the present study was to design a preoperative scoring system to prognosticate long-term outcomes in patients with LGGs. METHODS The authors conducted a retrospective review with long-term follow-up of 281 adults harboring hemispheric LGGs (World Health Organization Grade II lesions). Clinical and radiographic data were collected and analyzed to identify preoperative predictors of OS, progression-free survival (PFS), and extent of resection (EOR). These variables were used to devise a prognostic scoring system. RESULTS The 5-year estimated survival probability was 0.86. Multivariate Cox proportional hazards modeling demonstrated that 4 factors were associated with lower OS: presumed eloquent location (hazard ratio [HR] 4.12, 95% confidence interval [CI] 1.71-10.42), Karnofsky Performance Scale score < or = 80 (HR 3.53, 95% CI 1.56-8.00), patient age > 50 years (HR 1.96, 95% CI 1.47-3.77), and tumor diameter > 4 cm (HR 3.43, 95% CI 1.43-8.06). A scoring system calculated from the sum of these factors (range 0-4) demonstrated risk stratification across study groups, with the following 5-year cumulative survival estimates: Scores 0-1, OS = 0.97, PFS = 0.76; Score 2, OS = 0.81, PFS = 0.49; and Scores 3-4, OS = 0.56, PFS = 0.18 (p < 0.001 for both OS and PFS, log-rank test). This proposed scoring system demonstrated a high degree of interscorer reliability (kappa = 0.86). Four illustrative cases are described. CONCLUSIONS The authors propose a simple and reliable scoring system that can be used to preoperatively prognosticate the degree of lesion resectability, PFS, and OS in patients with LGGs. The application of a standardized scoring system for LGGs should improve clinical decision-making and allow physicians to reliably predict patient outcome at the time of the original imaging-based diagnosis.
Therapy with Bortezomib plus Dexamethasone Induces Osteoblast Activation in Responsive Patients with Multiple Myeloma

Bortezomib is a novel proteasome inhibitor that has shown marked antitumor effects in patients with multiple myeloma (MM). We evaluated the feasibility and efficacy of bortezomib plus dexamethasone (BD) therapy and assessed bone metabolism in relapsed or refractory MM. Fourteen patients received 1.3 mg/m2 bortezomib on days 1, 4, 8, and 11 along with 20 mg/dose of dexamethasone on days 1, 2, 4, 5, 8, 9, 11, and 12 in a 21-day cycle. After 1 to 3 cycles of BD therapy, 9 patients (64%) achieved an objective response (5 very good partial responses and 4 partial responses). Notably, a rapid increase in the serum concentration of alkaline phosphatase (ALP) was observed in 6 of the treatment-responsive patients. Moreover, serum levels of bone-formation markers (bone-specific ALP and osteocalcin) significantly increased in 5 and 2 responsive patients, respectively. Radiographic examination showed improvement in bone lesions, suggesting that BD therapy induces osteoblast activation in responders. Adverse events included thrombocytopenia of grades 1 to 3, peripheral neuropathy of grades 1 to 2, and grade 3 ileus and were transient and manageable. Although severe lung injury has been reported among Japanese patients treated with bortezomib, no pulmonary complications were observed during BD therapy. Our results suggest that BD therapy is a safe and promising therapeutic approach for Japanese patients with MM.
ExploreMaps: Efficient construction and ubiquitous exploration of panoramic view graphs of complex 3D environments

We introduce a novel efficient technique for automatically transforming a generic renderable 3D scene into a simple graph representation named ExploreMaps, where nodes are nicely placed point of views, called probes, and arcs are smooth paths between neighboring probes. Each probe is associated with a panoramic image enriched with preferred viewing orientations, and each path with a panoramic video. Our GPU‐accelerated unattended construction pipeline distributes probes so as to guarantee coverage of the scene while accounting for perceptual criteria before finding smooth, good looking paths between neighboring probes. Images and videos are precomputed at construction time with off‐line photorealistic rendering engines, providing a convincing 3D visualization beyond the limits of current real‐time graphics techniques. At run‐time, the graph is exploited both for creating automatic scene indexes and movie previews of complex scenes and for supporting interactive exploration through a low‐DOF assisted navigation interface and the visual indexing of the scene provided by the selected viewpoints. Due to negligible CPU overhead and very limited use of GPU functionality, real‐time performance is achieved on emerging web‐based environments based on WebGL even on low‐powered mobile devices.
Carbon management and environmental consequences of agricultural biomass in a Danish Renewable Energy strategy

This paper addresses the conversion of Danish agricultural land from food/feed crops to energy crops. To this end, a life cycle inventory, which relates the input and output flows from and to the environment of 528 different crop systems, is built and described. This includes seven crops (annuals and perennials), two soil types (sandy loam and sand), two climate types (wet and dry), three initial soil carbon level (high, average, low), two time horizons for soil carbon changes (20 and 100 years), two residues management practices (removal and incorporation into soil) as well as three soil carbon turnover rate reductions in response to the absence of tillage for some perennial crops (0%, 25%, 50%). For all crop systems, nutrient balances, balances between aboveand below-ground residues, soil carbon changes, biogenic carbon dioxide flows, emissions of nitrogen compounds and losses of macroand micronutrients are presented. The inventory results highlight Miscanthus as a promising energy crop, indicating it presents the lowest emissions of nitrogen compounds, the highest amount of carbon dioxide sequestrated from the atmosphere, a relatively high carbon turnover efficiency and allows to increase soil organic carbon. Results also show that the magnitude of these benefits depends on the harvest season, soil types and climatic conditions. Inventory results further highlight winter wheat as the only annual crop where straw removal for bioenergy may be sustainable, being the only annual crop not involving losses of soil organic carbon as a result of harvesting the straw. This, however, is conditional to manure application, and is only true on sandy soils.
Evaluation of decompression tables by Doppler technique in caisson work in The Netherlands.

INTRODUCTION Hyperbaric work was conducted for constructing an underground tramway in the Netherlands. A total of 11,647 exposures were conducted in 41,957 hours. For these working conditions specifically developed oxygen decompression tables were used. METHODS Fifteen workers were submitted to Doppler monitoring after caisson work at a depth at 12 msw. Measurements were done according to the Canadian DCIEM protocol. For bubble grading the Kisman-Masurel 12-points ordinal scale (0-IV) was used. RESULTS Bubbles were detected in 17 of the 38 examinations. The highest grade (III-) was found in four measurements. At rest the grading was never higher than I+. Two hours after decompression the grading was remarkably higher than after one hour. CONCLUSIONS Bubble scores were relatively low, although the maximum grading probably is not reached within two hours after decompression. It may be concluded that the oxygen decompression tables used, were reliable under these heavy working conditions. At group level, decompression stress can be evaluated by Doppler monitoring. In order to reduce health hazard of employees, use of oxygen during decompression in caisson work should be embodied in the occupational standard.
Modifications in stromal extracellular matrix of aged corneas can be induced by ultraviolet A irradiation

With age, structural and functional changes can be observed in human cornea. Some studies have shown a loss of corneal transparency and an increase in turbidity associated with aging. These changes are caused by modifications in the composition and arrangement of extracellular matrix in the corneal stroma. In human skin, it is well documented that exposure to solar radiation, and mainly to the UVA wavelengths, leads to phenotypes of photoaging characterized by alteration in extracellular matrix of the dermis. Although the cornea is also exposed to solar radiation, the extracellular matrix modifications observed in aging corneas have been mainly attributed to chronological aging and not to solar exposure. To ascertain the real implication of UVA exposure in extracellular matrix changes observed with age in human cornea, we have developed a model of photoaging by chronically exposing corneal stroma keratocytes with a precise UVA irradiation protocol. Using this model, we have analyzed UVA‐induced transcriptomic and proteomic changes in corneal stroma. Our results show that cumulative UVA exposure causes changes in extracellular matrix that are found in corneal stromas of aged individuals, suggesting that solar exposure catalyzes corneal aging. Indeed, we observe a downregulation of collagen and proteoglycan gene expression and a reduction in proteoglycan production and secretion in response to cumulative UVA exposure. This study provides the first evidence that chronic ocular exposure to sunlight affects extracellular matrix composition and thus plays a role in corneal changes observed with age.
Three essays on environmental valuation: the social value of carbon storage in wetlands, the impact of wind turbines on home prices, and the effect of flood risk on home prices

Climate change is a growing threat to socioeconomic systems at all geographic scales, from local to global. Each of the three essays in this paper looks at a different economic aspect of climate change, from the value of a blue carbon sink, the impact of renewable energy technology on property prices, and the effect of changing flood risk and coastal amenities on property prices. The first essay in this work looks at valuing changes in the economic value of carbon stored in tidal wetlands undergoing land cover change. Coastal wetland systems are highly effective at sequestering and storing carbon dioxide, and represent an important “Blue Carbon” sink. This essay first develops an economic model for valuing carbon sequestration and then applies the model to the Delaware Estuary. The annual value of net carbon sequestration is found to be between $5,000 and $44,000, and the Delaware estuary is losing between $165,000 and $7.33 million in sequestration potential each year, depending on discount rate used. The results of this study are useful for land management decisions in Delaware, and the model developed can be applied to valuing carbon sequestration in any ecosystem, provided sequestration rates are known. The second essay investigates the impact of the University of Delaware’s Wind Turbine in Lewes, Delaware, on local property prices. Wind turbine developments are frequently met with fervent local opposition, citing concerns over changing views, noise, and wildlife impacts, which may lead to reduced property prices. Using a hedonic valuation approach and advanced GIS techniques, this study finds no significant impact of the UD Wind Turbine on the majority of local property prices, with the exception of properties that are located closest to the turbine and are in full view. Results of this study are an important addition to the wind energy hedonic literature, contributing a
Computational modeling of beam-customization devices for heavy-charged-particle radiotherapy

A model for beam customization with collimators and a range-compensating filter based on the phase-space theory for beam transport is presented for dose distribution calculation in the treatment planning of radiotherapy with protons and heavier ions. Independent handling of pencil beams in conventional pencil-beam algorithms causes unphysical collimator-height dependence in the middle of large fields, which is resolved by the framework comprised of generation, transport, collimation, regeneration, range-compensation and edge-sharpening processes with a matrix of pencil beams. The model was verified to be consistent with measurement and analytic estimation at a submillimeter level in the penumbra of individual collimators with a combinational-collimated carbon-ion beam. The model computation is fast, accurate and readily applicable to pencil-beam algorithms in treatment planning with the capability of combinational collimation to make the best use of the beam-customization devices.
Building a reliable P2P system out of unreliable P2P clients: the case of KAD

Distributed Hash Tables (DHT) provide a framework for managing information in a large distributed network of nodes. One of the main challenges DHT systems must face is node churn, i.e., nodes can arrive and depart at any time. To assure that information published in a DHT remains available despite node churn is equivalent to building a reliable system out of unreliable components. In this paper we analyze KAD, a widely deployed DHT system. We focus on how to assure that information published in KAD remains available despite churn. We apply reliability theory to understand how the probability of finding an object published in KAD evolves over time. We also evaluate the cost, in terms of message exchanges, associated with the publishing scheme. Once we have identified the main weaknesses of the existing system, we propose an improved publishing scheme that is able to assure the same reliability but at a dramatically reduced cost. By exploiting knowledge about the lifetime of the nodes used to store the information, it is possible to reduce the publishing cost by one order of magnitude.
89Zr-mAb3481 PET for HER3 tumor status assessment during lapatinib treatment

ABSTRACT Treatment of human epidermal growth factor receptor 2 (HER2)-driven breast cancer with tyrosine kinase inhibitor lapatinib can induce a compensatory HER3 increase, which may attenuate antitumor efficacy. Therefore, we explored in vivo HER3 tumor status assessment after lapatinib treatment with zirconium-89 (89Zr)-labeled anti-HER3 antibody mAb3481 positron emission tomography (PET). Lapatinib effects on HER3 cell surface expression and mAb3481 internalization were evaluated in human breast (BT474, SKBR3) and gastric (N87) cancer cell lines using flow cytometry. Next, in vivo effects of daily lapatinib treatment on89Zr-mAb3481 BT474 and N87 xenograft tumor uptake were studied. PET-scans (BT474 only) were made after daily lapatinib treatment for 9 days, starting 3 days prior to 89Zr-mAb3481 administration. Subsequently, ex vivo 89Zr-mAb3481 organ distribution analysis was performed and HER3 tumor levels were measured with Western blot and immunohistochemistry. In vitro, lapatinib increased membranous HER3 in BT474, SKBR3 and N87 cells, and consequently mAb3481 internalization 1.7-fold (BT474), 1.4-fold (SKBR3) and 1.4-fold (N87). 89Zr-mAb3481 BT474 tumor uptake was remarkably high at SUVmean 5.6±0.6 (51.8±7.7%ID/g) using a 10 μg 89Zr-mAb3481 protein dose in vehicle-treated mice. However, compared to vehicle, lapatinib did not affect 89Zr-mAb3481 ex vivo uptake in BT474 and N87 tumors, while HER3 tumor expression remained unchanged. In conclusion, lapatinib increased in vitro HER3 tumor cell expression, but not when these cells were xenografted. 89Zr-mAb3481 PET accurately reflected HER3 tumor status. 89Zr-mAb3481 PET showed high, HER3-specific tumor uptake, and such an approach might sensitively assess HER3 tumor heterogeneity and treatment response in patients.
Environmental Security in P2P Networks

The great impact and growth of P2P networks in recent years make them an interesting target for hackers. But the development of P2P is aimed at improving the behavior of the networks, in computational terms, or to hide the transactions from observers. Security in P2P networks has been usually undervalued and not taken into account. This paper tries to highlight the major topics and challenges regarding P2P security, from a network infrastructure point of view (environmental security), providing some insights in current developments and available techniques that could be used to solve those problems.