Miracle-dz/UniFAR-FTUs huggingface dataset:
Learning Frameworks for Cooperative Spectrum Sensing and Energy-Efficient Data Protection in Cognitive Radio Networks

: This paper studies learning frameworks for energy-efﬁcient data communications in an energy-harvesting cognitive radio network in which secondary users (SUs) harvest energy from solar power while opportunistically accessing a licensed channel for data transmission. The SUs perform spectrum sensing individually, and send local decisions about the presence of the primary user (PU) on the channel to a fusion center (FC). We ﬁrst design a new cooperative spectrum-sensing technique based on a convolutional neural network in which the FC uses historical sensing data to train the network for classiﬁcation problem. The system is assumed to operate in a time-slotted manner. At the beginning of each time slot, the FC uses the current local decisions as input for the trained network to decide whether the PU is active or not in that time slot. In addition, legitimate transmissions can be vulnerable to a hidden eavesdropper, which always passively listens to the communication. Therefore, we further propose a transfer learning actor–critic algorithm for an SU to decide its operation mode to increase the security level under the constraint of limited energy. In this approach, the SU directly interacts with the environment to learn its dynamics (i.e., an arrival of harvested energy); then, the SU can either stay idle to save energy or transmit to the FC secured data that are encrypted using a suitable private-key encryption method to maximize the long-term effective security level of the network. We ﬁnally present numerical simulation results under various conﬁgurations to evaluate our proposed schemes.
High-order Higdon non-reflecting boundary conditions for the shallow water equations

In this report we document the implementation of high order Higdon nonreflecting boundary conditions. We suggest a way to choose the parameters and demonstrate numerically the efficiency of our choice. The model we used is the shallow water equations and as a special case the Klein-Gordon equation. These equations are solved by the finite difference method. We comment on the use of finite elements and demonstrate a new, more efficient method. The case of curved boundary is discussed. We close with a list of topics for research. 1. Statement of the Problem Consider the shallow water equations (SWEs) in a semi-infinite channel. For simplicity we assume that the channel has a flat bottom and that there is no advection, although these assumptions may be removed in future studies. We do take into account rotation (Coriolis) effects. A Cartesian coordinate system (x, y) is introduced such that the channel is parallel to the x direction, as shown in the figure. The width of the channel is denoted b.
Using Spatial Econometrics to Mitigate Omitted Variables in Stochastic Frontier Models: An Application to Norwegian Electricity Distribution Networks

An important methodological issue in efficiency analysis for incentive-based regulation of utilities is to account for the effect of unobserved cost drivers such as environmental factors. We combine a spatial econometric approach with stochastic frontier analysis to control for unobserved environmental conditions when measuring efficiency of electricity distribution utilities. Our empirical strategy relies on the geographic location of firms as a source of information that has previously not been explored in the literature. The underlying idea is to utilise data from neighbouring firms that can be spatially correlated as proxies for unobserved cost drivers. We illustrate our approach using a dataset of Norwegian distribution utilities for the 2004-2011 period. We find that the lack of information on weather and geographic conditions can be compensated with data from surrounding firms. The methodology can also be used in efficiency analysis and regulation of other utilities sectors where unobservable cost drivers (such as environmental variables) are important, e.g. gas, water, agriculture, fishing. This study combines stochastic frontier and spatial econometric techniques to evaluate a firm’s efficiency in the Norwegian electricity distribution sector, taking into account spatially correlated omitted variables. In doing so, first we propose estimating a spatial econometric model to obtain a proxy for this type of variable by means of the available data for neighbouring utilities. Next we plug the variable generated into a standard SFA model. We illustrate our approach using panel data for the Norwegian distribution utilities for the years 2004 to 2011. In order to implement our empirical strategy, we have matched the information on concession areas of distribution utilities with the data provided by the Norwegian regulator on firms’ costs. We are not aware of other studies that have carried out a similar spatial matching exercise.
Computer-Assisted Speech Perception Assessment (CASPA) Data in Adults with and without HIV

Objective: There is increasing literature on the association of HIV disease with hearing loss in adults, although only very limited research regarding communication, specifically in a background noise condition. The purpose of this study was to first, evaluate computer-assisted speech perception assessment (CASPA) data among adults living with HIV (ALHIV) and adults living without HIV (ALwoHIV). And second, to examine the association of HIV disease variables and HIV treatment with CASPA measures among ALHIV. Methods: A sample of 101 ALHIV (n=57) and ALwoHIV (n=44) participants from the Baltimore-Washington DC site of the Multicenter AIDS Cohort Study (MACS) and the Washington DC site of the Women’s Interagency HIV Study (WIHS) completed CASPA testing. Testing was performed in sound treated rooms using a speaker placed 3 ft away from the listener. Results: ALHIV and ALwoHIV had similar mean thresholds for phoneme and consonant scoring. ALHIV had poorer phoneme and consonant thresholds despite better ear 4 kHz thresholds compared to the ALwoHIV, suggesting difficulty with detecting speech-in-noise not related to diminished pure-tone thresholds. In ALHIV only, after adjusting for age, sex, nadir CD4+ T-cell count, and better ear 4 kHz threshold, total time on protease inhibitors (PIs) was significantly negatively associated with both phoneme threshold and consonant threshold, while total time on non-nucleoside reverse transcriptase inhibitors (NNRTIs) was marginally associated with both threshold measures. Conclusion: CASPA performance appeared to be poorer in ALHIV and these results suggest that HIV treatment (i.e., cumulative PI or NNRTI use) may preserve speech communication abilities in noise.
Increased Transmissibility of SARS-CoV-2 Lineage B.1.1.7 by Age and Viral Load: Evidence from Danish Households

Aim The aim of this study was to estimate the household transmissibility of SARSCoV-2 for lineage B.1. 1.7 compared with other lineages, by age and viral load. Furthermore, we wanted to estimate whether there is a multiplicative or additive effect of the increased transmissibility of B.1. 1.7 compared with other lineages. Background New lineages of SARS-CoV-2 are of potential concern due to higher transmissibility, risk of severe outcomes, and/or escape from neutralizing antibodies. Lineage B.1. 1.7 has been estimated to be more transmissible than other previously known lineages, but the association between transmissibility and risk factors, such as age of primary case and viral load is still unknown. Methods We used comprehensive administrative data from Denmark, comprising the full population, all SARS-CoV-2 RT-PCR tests, and all WGS lineage data (January 11 to February 7, 2021), to estimate household transmissibility stratified by lineage B.1. 1.7 and other lineages. Results We included 5,241 households with primary cases; 808 were infected with SARS-CoV-2 lineage B.1. 1.7 and 4,433 were infected with other lineages. The attack rate was 38% in households with a primary case infected with B.1. 1.7 and 27% in households with a primary case infected with other lineages. Primary cases infected with B.1. 1.7 had an increased transmissibility of 1.5-1.7 times that of primary cases infected with other lineages. The increased transmissibility of B.1. 1.7 was multiplicative across age and viral load. Conclusions The results found in this study add new knowledge that can be used to mitigate the further spread of SARS-CoV-2 lineage B.1. 1.7, which is becoming increasingly widespread in numerous countries. Our results clarify that the transmissibility of B.1. 1.7 should be included as a multiplicative effect in mathematical models used as a tool for decision makers. The results may have important public health implications, as household transmission may serve as a bridge between otherwise separate transmission domains, such as schools and physical workplaces, despite implemented non-pharmaceutical interventions.
Lessons for IT Project Manager Efficacy: A Review of the Literature Associated with Project Success

In the maturing IT project management space, there are still many debates about the skills needed to achieve success. This article presents a review and synthesis of project management literature that highlights the potential conflict in goals and the measurement of “success” from three perspectives: project outcomes, project management processes, and the project manager's influence. Our review indicates that each perspective of success, defined by various stakeholders at various points in time, shifts the focus onto different skills and knowledge. Drawing upon this tri-focal lens, we propose a shift in focus on success to the intersection, or “sweet spot of project manager efficacy. ”
OP-ICVA210150 1..9

OBJECTIVES: The aim of this study was to determine whether the preoperative thoracic muscle mass is associated with postoperative outcomes in patients undergoing lobectomy via thoracotomy for lung cancer. METHODS: Consecutive patients undergoing lobectomy were retrospectively reviewed. The thoracic muscle mass index (TMMI) was obtained at the level of the fifth thoracic vertebra on preoperative thoracic computed tomography (CT). Patients were analysed comparatively by being dividing into low and high muscle index groups by the median of sex-specific TMMI. The primary outcomes were the incidence of any or postoperative pulmonary complications. The secondary outcomes were postoperative intensive care unit (ICU) admission, length of stay (LOS) in the ICU, total hospital LOS, readmission and mortality. TH O R A C IC VC The Author(s) 2021. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved. Interactive Cardiovascular and Thoracic Surgery (2021) 1–9 ORIGINAL ARTICLE doi:10.1093/icvts/ivab150 D ow naded rom http/academ ic.p.com /icvts/advance-art.1093/icvts/ivab150/6318122 by gest on 16 uly 2021 RESULTS: The study population consisted of 120 patients (63.6 ± 9.8 years; 74% male). Each groups included 60 patients. Major complications occurred in 28.3% (34/120) and readmission in 18.3% (22/120) of patients. The adjusted multivariable analysis showed that each unit increase in TMMI (cm/m) was independently associated with the rates of less any complications [odds ratio (OR) 0.92, P = 0.014], pulmonary complications (OR 0.27, P = 0.019), ICU admission (OR 0.76, P = 0.031), hospitalization for >6 days (OR 0.90, P = 0.008) and readmission (OR 0.93, P = 0.029). CONCLUSIONS: Low TMMI obtained from the preoperative thoracic CT is an independent predictor of postoperative adverse outcomes in patients following lobectomy via thoracotomy for lung cancer. TMMI measurements may contribute to the development of preoperative risk stratification studies in the future.
BLOOD SUGAR REDUCING POTENTIALS AND HEAMATOLOGICAL PARAMETERS OF TURMERIC (CURCUMA LONGA) IN ALLOXAN-INDUCED DIABETIC ALBINO RAT (RATTUS NORVEGICUS)

Diabetes mellitus is a chronic metabolic disorder of glucose metabolism characterized by elevated blood sugar concentrations due to a loss of insulin-producing pancreatic β-cells (type 1 diabetes) or through loss of insulin responsiveness in its target tissues like adipose and muscle (type 2 diabetes). This study was undertaken to investigate the blood sugar reducing potential of turmeric. The duration of the study was 5 weeks and the experimental rats were fed standard rabbit pellet feed and water. Rats were grouped into 6 as follows: Group A - normal control, Group B - diabetic and not treated, Group C standard control, and Group D – F were diabetic and treated with different doses of turmeric (0, 100, 200 and 400 mg/kg) respectively. Data obtained were analyzed using One-way Analysis Variance (ANOVA). Oral administration of methanolic extract of turmeric led to a significant reduction in blood glucose levels and normalization of other haematological parameters. The extract helped stabilize blood sugar levels and made diabetes more manageable. Standard drug (Glibenclamide) effectively treated the diabetic condition of the experimental rats .
The risk of colorectal cancer is related to frequent hospitalization of IBD in an Asian population: results from a nationwide study

600 non-IBD subjects were enrolled. Cox proportional hazards regression was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) were used to assess the risk of CRC. Results: The incidence of CRC was slightly lower in the IBD cohort compared with that in the non-IBD cohort (0.94 vs. 1.13 per 1000 person-years), with an adjusted HR of 0.99 (95% CI: 0.71–1.37). More than four hospitalizations were associated with a significantly higher risk of CRC in IBD patients in the Cox model (adjusted HR = 3.48, 95% CI: 1.59–7.63). Conclusions: The risk for CRC was not increased among IBD patients overall, but appeared to be increased with cumulative frequency of hospitalizations for IBD.
1.1 ADOLESCENCE AS AN IMPORTANT PERIOD FOR GAINING MATURE SOCIAL GOALS

situations (bilateral IPL and bilateral STS) and neural activation in response to positive social situations (TPJ and mPFC). The results showed that individual differences in cognitive empathy and tendency to act prosocial were negatively related to activation in the left STS when viewing negative situations. These findings suggest that individuals with high empathy show less activation in the detection node of the brain when
Detection of Minimal Residual Disease in Acute Promyelocytic Leukemia by a Reverse Transcription Polymerase Chain Reaction Assay for the PML/RAR-a Fusion mRNA

The characteristic reciprocal translocation t(l5;17) of acute promyelocytic leukemia (APL) disrupts the PML gene on chromosome 15 and the retinoic acid receptor-a (RAR-a) gene on chromosome 17. PML/RAR-a fusion mRNAs are then transcribed and can be detected by a newly described reverse transcription polymerase chain reaction (RT-PCR) assay. Using RT followed by nested PCR amplification for PML/RAR-a, we serially evaluated bone marrow aspirates from patients with APL who were treated with all-trans retinoic acid (RA) for induction, followed by all-trans RA as maintenance or cytotoxic drugs as consolidation. At diagnosis, PML/RAR-a mRNA was de- tected in all patients. After initial therapy with all-trans RA, the RT-PCR assay remained positive after induction of complete remission in 31 of 32 evaluable patients. Maintenance treatment by all-trans RA alone was associated with persistent assay positivity and subsequent clinical relapse in 13 of 13 patients. By contrast, the test became negative in 19 of 20 newly diagnosed patients who received con-HE
Cytoskeletal Reorganization Complementary Roles in Signaling T Cell TCR, LFA-1, and CD28 Play Unique and

T cells interacting with APCs undergo rearrangement of surface receptors and cytoskeletal elements to face the zone of contact with the APC. This polarization process is thought to affect T cell signaling by organizing a specialized domain on the T cell surface and to direct T cell effector function toward the appropriate APC. We have investigated the contribution of TCR, CD28, and LFA-1 signaling to T cell cytoskeletal polarization by assaying the response of an Ag-speciﬁc Th1 clone toward a panel of transfected APCs expressing MHC class II alone or in combination with ICAM-1 or B7-1. We show that polarization of talin, an actin-binding protein, occurs in response to integrin engagement. In contrast, reorientation of the T cell microtubule-organizing center (MTOC) is dependent on and directed toward the site of TCR signaling, regardless of whether integrins or costimulatory molecules are engaged. MTOC reorientation in response to peptide-MHC complexes is sensitive to the phosphatidylinositol 3-kinase inhibitor wortmannin. CD28 coengagement overcomes this sensitivity, as does activation via Ab cross-linking of the TCR or via covalent peptide-MHC complexes, suggesting that phosphatidylinositol 3-kinase is not required per se but rather plays a role in signal ampliﬁcation. Engagement of TCR in trans with LFA-1 results in separation of MTOC reorientation and cortical cytoskeletal polarization events, indicating that the two processes are not directly mechanistically linked. These studies show that T cells mobilize individual cytoskeletal components in response to distinct and speciﬁc cell surface interactions. The Journal of Immunology, 1999, 162: 1367–1375.
CORRELATION BETWEEN BIOFILM FORMATION AND ANTIBIOTIC RESISTANCE IN UROPATHOGENIC PSEUDOMONAS AERUGINOSA CAUSING CATHETER ASSOCIATED URINARY TRACT INFECTIONS

Background and aim: Catheter associated urinary tract infections (CAUTI) accounts for 40% of nosocomial infections in hospitalized patients. P.aeruginosa is the third most common pathogen causing hospital acquired CAUTI. As there is paucity of literature about the pathogenesis of UTIs caused by P.aeruginosa , this study was undertaken with an aim to assess and correlate biofilm formation with antibiotic resistance in P.aeruginosa isolated from catheterized urine samples. Materials and Methods: 53 isolates of P.aeruginosa obtained from urine of patients with signs and symptoms of CAUTI following semi-quantitative culture on Mac Conkey agar were studied. Bacterial identification was based on colony morphology and standard biochemical tests. Antibiotic sensitivity was tested by Kirby Bauer disc diffusion method. Extended spectrum β-lactamase and metallo-β-lactamase production were detected by phenotypic disc confirmatory test and imipenem-EDTA double disk synergy test respectively. Biofilm formation was studied by microtitre plate assay. Results: Of the 53 isolates, 56.6% and 32.1% of were strong and moderate biofilm producers respectively. Among these 72.3% (24/47) were multidrug resistant which was statistically significant compared to weak/non-biofilm producers (P<0.001). MDR bacteria belonged to 5 different resistotypes. 21 (39.6%) and 11 (20.8%) isolates were ESBL and MBL producers respectively. Conclusion: This is one of the very few studies that has correlated the biofilm formation and antibiotic resistance in uropathogenic P.aeruginosa isolated from cases of CAUTI. Multi drug resistance was found to be significantly higher among the strong biofilm producers than the non-producers which implies that antibiotics should be chosen based on invitro antibiotic resistance patterns.
Pulmonary Epithelial FRA-1 Protooncogene Transcription in -Stimulated, c-Jun-Driven a Regulates TNF A JNK-Independent Signaling Pathway

(cid:2) mong the several effectors that mediate TNF- (cid:1) action is AP-1, which consists of transcription factors belonging to the JUN and FOS families. Although the effects of TNF- (cid:1) in immune cells, such as the induction of NF- (cid:3)(cid:4) , are well known, the mechanisms by which it induces transcriptional activation of AP-1 in pulmonary epithelial cells are not well deﬁned. In this study, we report that TNF- (cid:1) stimulates the expression of the FRA-1 protooncogene in human pulmonary epithelial cells using c-Jun, acting via a 12- O -tetradecanoylphorbol-13 acetate response element located at (cid:5) 318. Although TNF- (cid:1) stimulates phosphorylation of c-Jun, the inhibition of JNK activity had no signiﬁcant effect on FRA-1 induction. Consistent with this result, ectopic expression of a c-Jun mutant lacking JNK phosphorylation sites had no effect on the TNF- (cid:1) -induced expression of the promoter. In contrast, inhibition of the ERK pathway or ectopic expression of an ERK1 mutant strikingly reduced FRA-1 transcription. ERK inhibition not only blocked phosphorylation of Elk1, CREB, and ATF1, which constitutively bind to the FRA-1 promoter, but also suppressed the recruitment of c-Jun to the promoter. We found that short interfering RNA-mediated silencing of FRA-1 enhances TNF- (cid:1) -induced IL-8 expression, whereas overexpression causes an opposite effect. Our ﬁndings collectively indicate that ERK signaling plays key roles in both Elk1, CREB, and ATF-1 activation and the subsequent recruitment of c-Jun to the FRA-1 promoter in response
OTT_A_282933 12515..12519

1Department of Respiratory Oncology, Guangxi Medical University Affiliated Tumor Hospital, Nanning, China; 2Department of Research and Development, Nanjing Geneseeq Technology Inc, Nanjing, Jiangsu, China Abstract: Non-small cell lung cancer (NSCLC) patients with anaplastic lymphoma kinase (ALK) rearrangement benefit from treatment with ALK inhibitors. Therefore, the identification of druggable ALK fusions is necessary for NSCLC treatment. More than 90 fusion partners of ALK have been reported in NSCLC patients, but the striatin gene (STRN)-ALK fusion has rarely been reported. Moreover, the response of STRN-ALK fusion patients treated with ALK inhibitors remains to be explored. A 64-year-old Chinese male with no history of smoking or alcohol consumption was diagnosed as stage IVB lung adenocarcinoma (LADC) (cT4N3M1c) in October 2018. Next-generation sequencing (NGS) targeting 425 cancerrelated genes was performed on the plasma and supernatant of pleural effusion samples and revealed an STRN-ALK fusion. The patient received alectinib (600 mg, twice daily) as the first-line treatment with an excellent response exceeding 19 months. This is the first report of a NSCLC patient harboring an STRN-ALK fusion and exhibiting an excellent response to alectinib treatment. This case provides valuable information for therapeutic decision-making of patients with STRN-ALK fusions. Furthermore, this case also highlighted the advantage of performing targeted NGS on circulating tumor DNA for the identification and analysis of rare, druggable genomic alterations.