Miracle-dz/UniFAR-FTUs huggingface dataset:
Nutrient sensing and cAMP signaling in yeast: G-protein coupled receptor versus transceptor activation of PKA

A major signal transduction pathway regulating cell growth and many associated physiological properties as a function of nutrient availability in the yeast Saccharomyces cerevisiae is the protein kinase A (PKA) pathway. Glucose activation of PKA is mediated by G-protein coupled receptor (GPCR) Gpr1, and secondary messenger cAMP. Other nutrients, including nitrogen, phosphate and sulfate, activate PKA in accordingly-starved cells through nutrient transceptors, but apparently without cAMP signaling. We have now used an optimized EPAC-based fluorescence resonance energy transfer (FRET) sensor to precisely monitor in vivo cAMP levels after nutrient addition. We show that GPCR-mediated glucose activation of PKA is correlated with a rapid transient increase in the cAMP level in vivo, whereas nutrient transceptor-mediated activation by nitrogen, phosphate or sulfate, is not associated with any significant increase in cAMP in vivo. We also demonstrate direct physical interaction between the Gap1 amino acid transceptor and the catalytic subunits of PKA, Tpk1, 2 and 3. In addition, we reveal a conserved consensus motif in the nutrient transceptors that is also present in Bcy1, the regulatory subunit of PKA. This suggests that nutrient transceptor activation of PKA may be mediated by direct release of bound PKA catalytic subunits, triggered by the conformational changes occurring during transport of the substrate by the transceptor. Our results support a model in which nutrient transceptors are evolutionary ancestors of GPCRs, employing a more primitive direct signaling mechanism compared to the indirect cAMP second-messenger signaling mechanism used by GPCRs for activation of PKA.
Leukocyte profile of the helmeted manakin, Antilophia galeata (Passeriformes: Pipridae) in a Cerrado forest fragment

Changes in the amounts and proportions of leukocytes, known as leucocyte profiles, have been documented for several bird species and have been used to measure stress levels in these animals. The present work ascertained the biological and ecological attributes that influence the leukocyte profile of Antilophia galeata (Lichtenstein, 1823), the helmeted manakin. This species has been deemed useful in ecological studies because it responds to environmental changes. Blood samples drawn from 89 individuals of A. galeata captured in a Cerrado forest fragment were subjected to analysis under optical microscopy to identify and quantify leukocytes and micronuclei. The number of lymphocytes was greater for males, non-reproductive individuals and individuals infected with ticks. None of the leukocyte components differed in relation to age, molting or body condition index. The amount of micronuclei was correlated with values for total leukocytes, H/L ratio, heterophils, basophils and monocytes. The results suggest that reproduction may be an immunosuppressive factor for the species, producing sexual differences in lymphocyte availability. In addition, biomarkers of genotoxic damage (micronuclei) were related to the amount of leukocytes, indicating that individuals may be sensitive to environmental disturbances. Leukocyte profiles can be considered a useful tool for addressing ecological questions that are relevant to the conservation of species in degraded environments.
Investment Decisions, Asset Liquidity, and Stock Liquidity

Do managerial investment decisions affect the liquidity of a firm’s stock? We answer this question through a model that links investment decisions to the liquidity of a firm’s assets and the liquidity of its stock. Our model highlights the ambiguous effect of asset liquidity on stock liquidity. While greater asset liquidity reduces uncertainty regarding valuation of assets-in-place, it also increases future investments and the associated uncertainty. The model shows that asset liquidity has a more positive effect on stock liquidity for firms with less growth opportunities and for financially constrained firms. Empirically, we find a positive and economically large correlation between asset liquidity and stock liquidity. After controlling for firm fixed-effects, a one standard deviation increase in asset liquidity increases stock liquidity by 15%. The relation is more positive for firms with low growth opportunities, for financially constrained firms and for poorly governed firms. We find that a dollar of cash is worth seven to ten cents more for firms with less liquid stock. Apart from identifying a new determinant of stock liquidity, our analysis also promotes a new rationale for several empirical regularities such as the commonality in stock liquidity, and the improvement in stock liquidity following firm financing. ∗Radhakrishnan Gopalan (gopalan@wustl.edu) and Ohad Kadan (kadan@wustl.edu) are with the Olin Business School at Washington Universtity in St. Louis. Mikhail Pevzner (mpevzner@gmu.edu) is with the School of Management at George Mason University. We thank Joel Hasbrouck for graciously providing data on stock liquidity measures and Vanderbilt University’s Center for Research on Financial Markets for making available the data on bid-ask spreads. We are also grateful to Viral Acharya, Tarun Chordia, Paolo Fulghieri, Adriano Rampini, Ronnie Sadka, Mark Seasholes, and Avi Wohl and to seminar participants at Barclays Global Investors, Hong Kong University of Science and Technology, George Mason University, Nanyang Technological University, Singapore Management University, and Washington University for very helpful comments; and to Engin Kose and Anirudh Jonnavitula for assistance with data collection.
Modeling Hetero-Homogeneous Hierarchies and Mapping to OWL

The diploma thesis is devoted to a conceptual modeling approach for hetero-homogeneous hierarchies with multiple levels of abstraction. These hierarchies are homogeneous with respect to a common schema, defined by a single root node and prescribed for all sub-hierarchies, and are heterogeneous with respect to refined schemata for sub-hierarchies. In particular, the approach relies on so-called Generalized Multi-Level Objects and Generalized Multi-Level Relationships, which permit to represent objects and relationships among these objects at different levels. Both constructs can be arranged in concretization hierarchies, which compromise different aspects of abstraction hierarchies like e.g. aggregation, classification and generalization. In addition, a semantic-preserving mapping of such hierarchies to the decidable fragment of OWL (Web Ontology Language) is presented to render the approach from conceptual modeling to the semantic web and ontological engineering. By suitably combining closed world assumption and open world assumption, a meta-modeling facility in OWL is obtained, where OWL semantic reasoners allow e.g. consistency checks and respective query executions. Finally, data can be accessed in the semantic web at different abstraction levels of heterohomogeneous hierarchies, while its quality is improved. In the diploma thesis we mainly continue the ideas of Neumayr et al. [2009a,b, 2010], which are partially revised, compared to and complemented with own ideas and results.
Persistent increases of PKMζ in memory-activated neurons trace LTP maintenance during spatial long-term memory storage

PKMζ is an autonomously active PKC isoform crucial for the maintenance of synaptic long-term potentiation (LTP) and long-term memory. Unlike other protein kinases that are transiently stimulated by second messengers, PKMζ is persistently activated through sustained increases in kinase protein expression. Therefore, visualizing increases in PKMζ expression during long-term memory storage might reveal the sites of its persistent action and thus the location of memory-associated LTP maintenance in the brain. Using quantitative immunohistochemistry validated by the lack of staining in PKMζ-null mice, we examined the amount and distribution of PKMζ in subregions of the hippocampal formation of wild-type mice during LTP maintenance and spatial long-term memory storage. During LTP maintenance in hippocampal slices, PKMζ increases in the pyramidal cell body and stimulated dendritic layers of CA1 for at least 2 h. During spatial memory storage, PKMζ increases in CA1 pyramidal cells for at least 1 month, paralleling the persistence of the memory. The subset of CA1 pyramidal cells that are tagged by immediate early gene Arc-driven transcription of fluorescent proteins, whose expression increases during initial memory formation, also expresses the persistent increase of PKMζ during memory storage. In the memory-tagged cells, the increased PKMζ expression persists in dendritic compartments within stratum radiatum for 1 month, indicating the long-term storage of information in the CA3-to-CA1 pathway during remote spatial memory. We conclude that persistent increases in PKMζ trace the molecular mechanism of LTP maintenance and thus the sites of information storage within brain circuitry during long-term memory.
On the Gibbs adsorption equation and diffuse interface models

In this paper we discuss some applications of the classical Gibbs adsorption equation to specific diffuse interface models that are based on conserved and non–conserved order parameters. Such models are natural examples of the general methodology developed by J. W. Gibbs in his treatment of the thermodynamics of surfaces. We employ the methodology of J. W. Cahn, which avoids the use of conventional dividing surfaces to define surface excess quantities. We show that the Gibbs adsorption equation holds for systems with gradient energy coefficients, provided the appropriate definitions of surface excess quantities are used. We consider, in particular, the phase–field model of a binary alloy with gradient energy coefficients for solute and the phase field. We derive a solute surface excess quantity that is independent of a dividing surface convention, and find that the adsorption in this model is influenced by the surface free energies of the pure components of the binary alloy as well as the solute gradient energy coefficient. We present one–dimensional numerical solutions for this model corresponding to a stationary planar interface and show the consistency of the numerical results with the Gibbs adsorption equation. We also discuss the Gibbs adsorption equation in the context of other diffuse interface models that arise in spinodal decomposition and order–disorder transitions.
INFLUENCE OF FOLIAR APPLICATION OF NPK ON GROWTH, ESSENTIAL OIL AND SEED YIELD OF BASIL (OCIMUM

Basil (Ocimum basilicum L.) is an important plant belonging to the Lamiaceae family. Basil is grown in different countries as a medicinal and aromatic plant. Basil production can be influenced by abiotic and biotic stresses including plant nutrition deficiency. Thus, a field experiment was conducted in a completely randomized design during summer 2019 to investigate the effect of foliar application of NPK fertilizer (0.0, 0.5, 1.0, 1.5, 2.0 and 2.5 g/L) on growth, essential oil and seed yield of basil. Applying moderate levels of NPK fertilizer is proposed to be sufficient for high vegetative growth traits and essential oil production. The highest non-reproductive biomass yield was recorded at a dose of 1.0 to 2.0 g/L. The highest amount of essential oil was determined in plants fertilized with NPK dose of 1.5 g/L. Applying NPK fertilizer (1.5 to 2.0 g/L) produced the highest seed yield. Generally, NPK application as foliar fertilizer contributed to the increase of most plant traits compared to control (0 g/L) in basil.
Gas−Liquid Solubility of Hydrogen in n-Alcohols (1 ⩽ n ⩽ 4) at Pressures from 3.6 MPa to 10 MPa and Temperatures from 298.15 K to 525.15 K

The gas−liquid solubility of hydrogen in methanol, ethanol, 1-propanol, and 1-butanol at pressures in the range 3.6 to 10 MPa and at temperatures in the range 298.15 to 525.15 K has been measured in an autoclave type phase equilibrium apparatus using the total pressure method. Pseudo-Henry's law constants, , were calculated. The solubility of hydrogen increases with increasing temperature and pressure for all solvents used, and it also increases as the carbon chain length of the alcohol molecule increases.
RELATIONSHIP BETWEEN POSITIVITY, POSITIVE AND NEGATIVE EFFECTS AMONG CARDIAC PATIENTS: MEDIATING ROLE OF PERCEIVED STRESS

1 Zhongtai Securities, Institute for Financial Studies, School of Mathematics, Shandong University, Jinan, CHINA. 2 Department of Psychology International Islamic University, Islamabad, PAKISTAN. 3 School of Medicine, Shandong University, Jinan, CHINA. 4 School of Psychology, Shaanxi Normal University, Xi’an, CHINA 5 Department of Health Psychology, School of Nursing, Shandong University, Jinan, CHINA.
BlueConnect: Novel Hierarchical All-Reduce on Multi-tired Network for Deep Learning

In this paper, we present BlueConnect, an efﬁcient communication library for distributed deep learning that is highly optimized for popular GPU-based platforms. BlueConnect decomposes a single all-reduce operation into a large number of par-allelizable reduce-scatter and all-gather operations to exploit the trade-off between latency and bandwidth, and adapt to a variety of network conﬁgurations. Therefore, each individual operation can be mapped to a different network fabric and take advantage of the best performing implementation for the corresponding fabric. According to our experimental results, the BlueConnected integrated Caffe2 can signiﬁcantly reduce synchronization overhead by 87% on 192 GPUs for Resnet-50 training over prior schemes.
Association Between Neuromuscular Characteristics of Agility in Jumping Tasks

Association Between Neuromuscular Characteristics of Agility in Jumping Tasks Lara Boman Director: Dr. Talin Louder, PhD This study evaluated the influence of drop height on and the statistical associations between Sheppard & Young’s (2006) three neuromuscular characteristics of agility: reactive strength, concentric strength and power, and bilateral symmetry. Nine NCAA DI women’s volleyball players completed a depthjumping protocol at three different drop heights. Ground reaction force data was used to calculate the reactive strength index (RSI); peak and average power, peak and average force; and percent differences between the right and left lower limbs in peak and average power and force. Each neuromuscular characteristic was statistically associated with drop height, each of the other two neuromuscular characteristics, and rebound jump height. Linear regressions provided association data. The strongest association was between RSI and rebound jump height. Average force was moderately associated with RSI and weakly associated with rebound jump height. Peak power was weakly associated with RSI. This information could be used by health practitioners to better design training programs that improve vertical agility capabilities in athletes.
Proposing a Conceptual Model for Effective Administrative System

Social and economic changes together with increased public costs have forced public organizations to pay much attention to promotion of their performance as a vital issue. Many scholars believe that success or failure of governments and social health and happiness depend on its public management. It is well documented that through the time, the necessity for dealing with new demands in managerial, political, legal and professional fields in public organizations is increasing, and legitimacy and survival of governments depend on their attempts to revise their administrative systems making them proportional to managerial, political, legal and professional aspects and responsive to these four demands in society; and consider a combination of these dimensions in solving the problems. The objective of the present paper is to propose a conceptual model for effective administrative system integrating managerial, political, legal and professional dimensions with an ecological approach. In the other words, administrative system of each country should be studied in the light of value framework dominating the society or native culture.
EVALUATION OF ANGIOTENSIN CONVERTING ENZYME GENE POLYMORPHISM AS A RISK FOR MYOCARDIAL INFARCTION WITH / WITHOUT TYPE 2 DIABETIC IRAQI PATIENTS

Background: Ischemic heart disease (IHD) is the term given to heart problems the lipids in the blood are deposited on the end atrium due to abnormal lipids (metabolism). Due to the higher morbidity rate and mortality rate, IHD has become the most serious cardiovascular disease threatening in Iraqi people. The most common cause of myocardial infarction is atherosclerotic disease of an epicardial coronary artery (or arteries) sufficient to cause a regional reduction in myocardial blood flow and inadequate perfusion of the myocardium supplied by the involved coronary artery. It may affect individuals at any age, the most common risk factors include smoking, family history, hypertension, obesity, diabetes, high alcohol consumption, lack of exercise, stress, and hyperlipidemia. Various studies have shown that the polymorphisms angiotensin-converting enzyme ACE (DD) (rs4646994) associated with various heart diseases. Objective: To study the correlation between ACE (DD) (rs4646994) gene polymorphism with each of lipid profile and troponin I in hypertensive male Iraqi patients of myocardial infarction with / without type 2 diabetes mellitus. Materials and Methods: This case–control study composed of 217 adult males which were classified into three groups: Group I comprised 86 patients with myocardial infarction before catheterization with type 2 diabetes mellitus. Group II comprised 78 patients with myocardial infarction without T2DM which were admitted in Al-Hussein Medical City Teaching Hospitals / Kerbala Health Directorate Iraq during 1 st , Dec. 2018 to 31, July 2019. Group III comprised of 53 apparently healthy individuals as a control group. The risk factors include smoking, family history, hypertension and T2DM. DNA was extracted from whole blood and genotyping was achieved with specific (primers to amplify) the 3 genotypes by using PCR-ARMS techniques. Results: The high frequency of D allele in diabetic group act as independent risk factor. The observed data indicated that ACE-DD homotype was higher in T2DM patients as compared to controls. The genotypes for the ACE (DD)(rs4646994) gene band was observed in (190 pb) which indicate the removal a single nucleotide from gene that called homozygotes. Conclusion: A positive correlation of angiotensin-converting enzyme (DD) (rs4646994) gene polymorphism in myocardial infarction with and without T2DM for in Iraqi patients were observed.
OP-NDTJ200215 1..13

Mineral and bone disorder (MBD) is widely prevalent in children with chronic kidney disease (CKD) and is associated with significant morbidity. CKD may cause disturbances in bone remodelling/modelling, which are more pronounced in the growing skeleton, manifesting as short stature, bone pain and deformities, fractures, slipped epiphyses and ectopic calcifications. Although assessment of bone health is a key element in the clinical care of children with CKD, it remains a major challenge for physicians. On the one hand, bone biopsy with histomorphometry is the gold standard for assessing bone health, but it is expensive, invasive and requires expertise in the interpretation of bone histology. On the other hand, currently available non-invasive measures, including dual-energy X-ray absorptiometry and biomarkers of bone formation/resorption, are affected by growth and pubertal status and have limited sensitivity and specificity in predicting changes in bone turnover and mineralization. In the absence of high-quality evidence, there are wide variations in clinical practice in the diagnosis and management of CKD-MBD in childhood. We present clinical practice points (CPPs) on the assessment of bone disease in children with CKD Stages 2–5 and on dialysis based on the best available evidence and consensus of experts from the CKDMBD and Dialysis working groups of the European Society for Paediatric Nephrology and the CKD-MBD working group of the European Renal Association–European Dialysis and Transplant Association. These CPPs should be carefully considered by treating physicians and adapted to individual patients’ needs as appropriate. Further areas for research are suggested.
The Effectiveness of Orange Essential Oil Aromatherapy on Blood Pressure, Pulse Rate, and Respiratory Rate of Patients Scheduled for Coronary Angiography: A Clinical Trial

Background: Patients scheduled for angiography experience pre-operative anxiety, which affects vital signs. Objectives: The current study aimed to investigate the effectiveness of orange essential oil aromatherapy on blood pressure, pulse rate, and respiratory rate of patients before coronary angiography. Methods: In this clinical trial, 70 patients scheduled for coronary angiography were separated into two groups of intervention and control. For those in the intervention group, two drops of orange essential oil were drip by emitters on a polyethylene handkerchief attached to the collar of the participants. Then, they were asked to breathe normally for 20 minutes. Vital signs were recorded before and after providing the intervention. Data were analyzed using SPSS version 16 using Chi-square, Fisher's exact test, independent ttest, U Mann-Whitney, Paired Wilcoxon, and paired t-test. Results: There was no significant difference between the two groups concerning the mean vital signs before providing the intervention. However, after providing the intervention, a significant difference was found concerning pulse rate (71.3±26.79), respiratory rate (15.2±11.04), and systolic blood pressure (117.9±31.47) between the two groups (P<0.001). In the control group, no significant difference was found concerning the pulse rate (75.3±06.72), respiratory rate (17.2±18.28), and systolic blood pressure (123.8±91.91) before and after providing the intervention (P>0.001), and this difference was significant between the two groups (P<0.001). Also, there was no significant difference between the two groups concerning the diastolic blood pressure (P>0.001). Conclusion: This study demonstrated that orange essential oil, as a complementary method, can reduce pulse rate, respiratory rate, and systolic blood pressure in people undergoing coronary angiography. Therefore, it can be considered as a safe and cheap alternative therapeutic option.
STDP-Induced Periodic Encoding of Static Patterns in Balanced Recurrent Neural Networks

We present learning simulation results on a balanced recurrent neural network of spiking neurons, in a situation where the sensory context is dominated by the internal inﬂuence. Under our settings, the spontaneous responses are random-like and the different input patterns are difﬁcult to discriminate. We present a simple implementation of the classical STDP learning rule : the "balanced STDP" where the potentiation and depression effects compensate. We show that under the application of this rule, the network level of activity is preserved. The only change is qualitative : starting from a near-random activity, the network learns to associate a periodic response in the presence of a particular static input. During the application of the STDP, the activity progressively regularizes and the internal period slightly shrinks. This strong periodic shaping of the response is obtained fore relatively light weight changes. This particular response is moreover found to be speciﬁc to one particular pattern out of the initial set, displaying interesting selectivity properties.