Miracle-dz/UniFAR-FTUs huggingface dataset:
Characterization of Family 17 and Family 28 Carbohydrate-Binding Modules from Clostridium josui Cel5A

The endoglucanase Cel5A from an anaerobic celluloltyic bacterium, Clostridium josui, contains family 17 CBM (CjCBM17) and family 28 CBM (CjCBM28) in tandem. Individual CjCBM17 and CjCBM28 and tandem CjCBM17/28 were constructed to determine the binding characteristics of CjCBM17/28 and to compare the binding affinity of the three CBMs. CjCBM17/28 bound to non-crystalline cellulose, soluble cellulose derivatives, and oat-spelt xylan, but not to birchwood xylan or starch. The thermodynamic parameters for the binding of the CBMs with cellooligosaccharides were determined by isothermal titration calorimetry. The binding of CjCBM28 to cellotetraose and cellopentaose was enthalpically driven (large negative ΔH value), while that of CjCBM17 was entropically driven (positive ΔS value). These two CBMs had different mechanisms for binding to cellooligosaccharides. They showed similar binding constants (K a) for cellopentaose, but in the case of insoluble polysaccharides, the K a of CjCBM17/28 was approximately 3–7 times higher than that of individual CBMs.
Formant manipulations in voice disguise by mimicry

The human voice can be disguised in many ways. The purpose of disguise could either be to impersonate another person, or to conceal the identity of the original speaker, or both. On the other hand, the goal of any biometric analysis on disguised voices could also be twofold: either to find out if the originator of the disguised voice is a given speaker, or to know how a speaker's voice can be manipulated so that the extent and type of disguise that the speaker can perform can be guessed a-priori. Any analysis toward the former goal must rely on the knowledge of what characteristics of a person's voice are least affected or unaffected by attempted disguise. Analysis towards the latter goal must use the knowledge of what sounds are typically most amenable to voluntary variation by the speaker, so that the extent to which given speakers can successfully disguise their voice can be estimated. Our paper attempts to establish a simple methodology for analysis of voice for both goals. We study the voice impersonations performed by an expert mimic, focusing specifically on formants and formant-related measurements, to find out the extent and type of formant manipulations that are performed by the expert at the level of individual phonemes. Expert mimicry is an extreme form of attempted disguise. Our study is presented with the expectation that non-expert attempts at voice disguise by mimicry will fall within the gold standard of manipulation patterns set by an expert mimic, and that it is therefore useful to establish this gold standard.
A Twin Study on Humor Appreciation The Importance of Separating Structure and Content

The present study focused on genetic and environmental influences on appreciation of structure and content of humor. Monozygotic (n = 135) and dizygotic (n = 60) adult twin pairs rated their trait-like humor appreciation using the 3 WD humor test (Ruch, 1992) which assesses three basic humor stimuli (incongruity-resolution humor; nonsense humor; sexual humor), and two basic components of responses to humor (funniness; aversiveness). Additionally, two indices were derived from these scales, namely structure preference and liking of sexual content (i.e., controlled for humor structure). Intraclass correlations and behavior genetic model-fitting analyses indicated a moderate genetic effect for funniness ratings of liking the sexual content. The remaining funniness scales seemed entirely influenced by environmental effects. Aversiveness scales mainly showed environmental effects represented in reduced CE models, although twin similarity coefficients showed hints of genetic influences as well, which needs to b.
Learning Asymmetric Co-Relevance

Several applications in information retrieval rely on asymmetric co-relevance estimation; that is, estimating the relevance of a document to a query under the assumption that another document is relevant. We present a supervised model for learning an asymmetric co-relevance estimate. The model uses different types of similarities with the assumed relevant document and the query, as well as document-quality measures. Empirical evaluation demonstrates the merits of using the co-relevance estimate in various applications, including cluster-based and graph-based document retrieval. Specifically, the resultant performance transcends that of using a wide variety of alternative estimates, mostly symmetric inter-document similarity measures that dominate past work.
Journal of Neuroengineering and Rehabilitation Open Access Ambulatory Measurement of Knee Motion and Physical Activity: Preliminary Evaluation of a Smart Activity Monitor

Background: There is currently a paucity of devices available for continuous, long-term monitoring of human joint motion. Non-invasive, inexpensive devices capable of recording human activity and joint motion have many applications for medical research. Such a device could be used to quantify range of motion outside the gait laboratory. The purpose of this study was to test the accuracy of the modified Intelligent Device for Energy Expenditure and Activity (IDEEA) in measuring knee flexion angles, to detect different physical activities, and to quantify how often healthy subjects use deep knee flexion in the ambulatory setting.
Post Deposition Heat Treatment Effects on Ceramic Superconducting Films Produced by Infrared Nd:YAG Pulsed Laser Deposition

Pulsed laser deposition (PLD) has become a potential method in fabricating highly quality superconducting thin films suitable for electronic applications such as in Josephson junctionbased electronics and in second generation coated conductors [11, 12, 14, 20, 23]. PLD of high Tc superconductors generally utilize excimer lasers in the ultraviolet (UV) range [6, 11] . However, excimer lasers use toxic gases such as Cl and F for excitation. In contrast, flash lamp pumped Nd:YAG laser can provide stable power and better beam profile [14, 20]. Nd: YAG lasers are also easy to operate and have low maintenance costs [2, 14, 20]. To date, the third harmonic (355 nm) and fourth harmonic (266 nm) of the Nd:YAG has been used to grow high quality high-Tc superconducting films [12, 14, 20].
Coordination of Rhythmic Motor Activity by Gradients of Synaptic Strength in a Neural Circuit That Couples Modular Neural Oscillators

Synchronization of distributed neural circuits is required for many behavioral tasks, but the mechanisms that coordinate these circuits are largely unknown. The modular local circuits that control crayfish swimmerets are distributed in four segments of the CNS, but when the swimmeret system is active their outputs are synchronized with a stable intersegmental phase difference of 0.25, an example of metachronal synchronization (Izhikevich, 2007). In each module, coordinating neurons encode detailed information about each cycle of the module's motor output as bursts of spikes, and their axons conduct this information to targets in other segments. This information is both necessary and sufficient for normal intersegmental coordination. In a comprehensive set of recordings, we mapped the synaptic connections of two types of coordinating neurons onto their common target neurons in other segments. Both types of coordinating axons caused large, brief EPSPs in their targets. The shape indices of these EPSPs are tuned to transmit the information from each axon precisely. In each target neuron's own module, these bursts of EPSPs modified the phase of the module's motor output. Each axon made its strongest synapse onto the target neuron in the nearest neighboring segment. Its synapses onto homologous targets in more remote segments were progressively weaker. Each target neuron decodes information from several coordinating axons, and the strengths of their synapses differ systematically. These differences in synaptic strength weight information from each segment differently, which might account for features of the system's characteristic metachronal synchronization.
Assessment transcallosal Diaschisis in a model of focal cerebral ischemia in rats

Objective: To evaluate transcallosal changes after a local ischemic injury in rats by using the monoclonal marker anti-NeuN (Mouse anti-neuronal nuclei). Methods: Twenty-eight adult, male, Wistar rats were subjected to focal injury in the right hemisphere. The technique used was the experimental model of focal ischemic injury through intraluminal suture of the middle cerebral artery. Analyses were made for the five groups: after the lesion (control), at 24 h, 96 h, 10 days and 20 days. Exofocal neuronal damage was inferred from neuronal immunoreactivity changes to NeuN. Results: In the cortex contralateral to the lesion, immunoreactivity was diminished. This finding was most notable in the supra-granular sheets 24 h post ischemia. After 96 h, there was a generalized diminishment of the inmmunoreactivity in the supra and infra-granular sheets. At 10 and 20 days, the tissue recovered some immunoreactivity to NeuN, but there were some changes in the VI layer. Conclusion: The immunoreactive changes to NeuN support the process of inter-hemispheric diaschisis. Changes in immunoreactivity could indicate metabolic stress secondary to the disruption in connectivity to the site of lesion.
A case study on a home-based caregiver-delivered music-with-movement intervention for people with early dementia

Background: Music has been found to improve sleep and reduce anxiety. Purpose: This article reports a 78-year-old Chinese female who had been diagnosed with early dementia underwent an 8-week music-with-movement intervention delivered by her husband at home after being trained in a day care center. Methods: Both the patient and the husband’s data were collected through repeated interviews and regular observations. Conclusion: The results indicated signs of improvement of the patient in terms of sleep quality and depressive symptoms.
The Effects of Variations in Conductivity and Geometrical Parameters on the Electrocardiogram, Using an Eccentric Spheres Model

The effects of variations in the volume conductor properties of the torso on the electrocardiogram were studied by means of a theoretical eccentric spheres model. The model includes a blood cavity, cardiac muscle layer, pericardium, lung region, skeletal muscle layer, and subcutaneous fat. The source of the field is a double-layer spherical cap located within the myocardium. The following effects regarding the electrocardiogram (ECG) potentials were determined: (1) blood augments the potential, but less than predicted by simpler published models; (2) in anemia, high potentials are expected, whereas in polycythemia, voltages are reduced; (3) abnormally low lung conductivity (emphysema) causes low surface potentials whose magnitude is controlled by the low conductivity skeletal muscle layer; (4) low voltages result both from low and high pericardial conductivities; (5) the surface potential increases with increasing myocardial conductivity; (6) low skeletal muscle conductivity (Pompe's disease) causes high surface potentials; (7) obesity lowers the potential only slightly; (8) a thick myocardium, protruding into the lung region, slightly augments the potential; (9) an increase in the thickness of the myocardium at the expense of the blood cavity causes a decrease in potential; (10) the potential increases with increasing heart size; and (11) the location of the heart within the torso has a very significant effect on the surface potential distribution. cire Res 104-111, 1979
A plastic crack in a smectic liquid crystal – a possible model

A plastic crack model for smectic A liquid crystals is suggested in this article. The solution for the crack problem is based on the dislocation pile-up principle and the singular integral equation method. From the solution we can determine the size of the plastic zone at the crack tip and the crack tip opening (sliding) displacement, which are parameters relevant to the stability/instability of materials. The results may be useful in developing soft-matter mechanics.
Practical algorithms for fully decoupled mixed-mode simulation of electronic circuits

Mixed-mode, device and circuit simulation of electronic circuits is an important tool when accurate treatment of nonlinear devices within a circuit is required. The two currently favoured approaches, the two-level and full Newton methods, each require some amendment to the device simulator code. Alternative, purely numerical decoupled techniques have received little attention owing to their relative inefficiency. We examine two approaches-the choice of an alternative nonlinear solution technique, and parallelisation-by which such "Black Box" methods might be rendered feasible.
Sequential Modeling of Topic Dynamics with Multiple Timescales

We propose an online topic model for sequentially analyzing the time evolution of topics in document collections. Topics naturally evolve with multiple timescales. For example, some words may be used consistently over one hundred years, while other words emerge and disappear over periods of a few days. Thus, in the proposed model, current topic-specific distributions over words are assumed to be generated based on the multiscale word distributions of the previous epoch. Considering both the long- and short-timescale dependency yields a more robust model. We derive efficient online inference procedures based on a stochastic EM algorithm, in which the model is sequentially updated using newly obtained data; this means that past data are not required to make the inference. We demonstrate the effectiveness of the proposed method in terms of predictive performance and computational efficiency by examining collections of real documents with timestamps.
Levonorgestrel-releasing intrauterine system (Mirena) in compare to medroxyprogesterone acetate as a therapy for endometrial hyperplasia

Background: This study was designed to evaluate the comparison of insertion of levonorgestrel (LNG)-releasing intrauterine system versus oral medroxyprogesterone acetate on endometrial hyperplasia in a randomized controlled trial. Materials and Methods: A total of 60 women with the initial histopathological diagnosis of endometrial hyperplasia in two groups received LNG or medroxyprogesterone (10 mg/d orally) for 12 days a month for 3 months). Endometrial biopsy was obtained for all patients after 3 months of treatment. Response to treatment was defined based on the histopathology of the post treatment pipelle endometrial specimens in three categories of resolution, persistence and progression. Results: Treatment response rate in patients in the LNG group was 89.3% (25 of 28 patients), versus 70.4% (19 of 27 patients) in patients in the medroxyprogesterone group. The rate of persistence was 10.7% (3 of 28 patients) and 22.2% (6 of 27 patients) in LNG and medroxyprogesterone groups respectively. No progression of endometrial hyperplasia observed in any of the patients in LNG group, but progression of endometrial hyperplasia was observed in 7.4% (2 of 27 patients) in the medroxyprogesterone group. There was no statistically significant difference between groups regarding the response to treatment (P = 0.15). Side effects such as bloating, weight gain, fatigue and hair loss were comparable between the groups (P > 0.05). Hirsutism was significantly more in the medroxyprogesterone group than LNG group (P = 0.013). Conclusion: Results showed that the use of LNG for treating endometrial hyperplasia for 3 months was associated with high-treatment response rate and the low proportion of patients with progression compared to the use of medroxyprogesterone.
PENGARUH PUTARAN DAN KECEPATAN TOOL TERHADAP SIFAT MEKANIK PADA PENGELASAN FRICTION STIR WELDING ALUMINIUM 5052

Aluminium is a metal that has a good resistance against corrosion, this is because the occurrence of the phenomenon of pasivasi. In addition to its resistance to corrosion, aluminium also has a lighter weight compared to steel, so aluminium is frequently used as one of the materials used in the manufacture of ships, especially on the upper deck of the building, insulation, fuel tanks and freshwater tank.Welding is the process of connecting between two or more metal parts by using thermal energy.In general aluminum welding using fusion welding processes such as Metal Inert Gas and Metal Inert Gas, but on both of these methods there is possibility formation of defects are porosity, cracks and prone to occurringdeformationduringcooling processof dan the formation ofmetalwelding. The purpose of this study was to determine the effect of tool rotation and welding speed on the mechanical aspect of Aluminium 5052 with the friction stir welding method.The parameters of the welding process is done on the research this is is the round tool and welding spee is is the round tool and welding speed. Round tool used there are two namely 1800 rpm and 1100 rpm. The speed of welding is also used there are two variations,namely 11.4 mm/min and 19.8 mm/min. As for the mechanical tests conducted there are three, namely testing the hardness, impact test, and tensile testing.The result of this research was the discovery that the round tool and welding speed greatly affect the mechanical properties of aluminium that has been welded. Because the tool is rotating faster increases the tensile strength of aluminium, while the small welding speed will increase the hardness of aluminum that has been welded. Keywords : aluminium, welding, friction stir welding, mechanical aspect of metals
Diabetic neuropathy: an intensive review.

PURPOSE The epidemiology, classification, pathology, and treatment of diabetic neuropathy are reviewed. SUMMARY Diabetic peripheral neuropathy is a common complication of diabetes that can cause significant morbidity and mortality. Some 30% of hospitalized and 20% of community-dwelling diabetes patients have peripheral neuropathy; the annual incidence rate is approximately 2%. The primary risk factor is hyperglycemia. Sensorimotor neuropathy is marked by pain, paresthesia, and sensory loss. Cardiac autonomic neuropathy (CAN) may contribute to myocardial infarction, malignant arrhythmia, and sudden death. Gastroparesis is the most debilitating complication of gastrointestinal autonomic neuropathy. Genitourinary autonomic neuropathy can cause sexual dysfunction and neurogenic bladder. The pathology of diabetic neuropathy involves oxidative stress, advanced glycation end products, polyol pathway flux, and protein kinase C activation; all contribute to microvascular disease and nerve dysfunction. For symptom management current evidence from clinical trials supports the use of desipramine, amitriptyline, capsaicin, tramadol, gabapentin, bupropion, and venlafaxine as preferred medications. Citalopram, nonsteroidal antiinflammatory drugs, and opioid analgesics may be used as adjuvant agents. Lamotrigine, oxcarbazepine, paroxetine, levodopa, and alpha-lipoic acid are alternative considerations. Evidence supporting the use of zonisamide, fluoxetine, mexiletine, dextromethorphan, and phenytoin is considered equivocal. Complementary therapies have also shown efficacy. The symptoms of CAN may be ameliorated with fludrocortisone, clonidine, midodrine, dihydroergotamine or caffeine, octreotide, and beta-blockers. Gastroparesis may be treated with metoclopramide or erythromycin. The most promising disease-modifying therapy is ruboxistaurin, which is in Phase III trials. Glycemic control remains the foundation of prevention and the prerequisite of adequate treatment. CONCLUSION Diabetic neuropathy is a many-faceted complication of diabetes that can be managed symptomatically with an array of drugs.
The systems analyst as a knowledge engineer: can the transition be successfully made?

The general view evident in current expert systems literature is that personnel requirements for development of expert systems are quite different from those for conventional information systems. The necessary knowledge, skills, and personality traits for expert systems development are embodied in a new breed of computer professional called the Knowledge Engineer. The purpose of this paper is to: 1) examine the similarities and differences between the personal characteristics of the systems analyst and knowledge engineer and the work they perform, and 2) define an action plan specifically dealing with the personnel issues for management information systems (MIS) managers introducing expert systems technology into the organization.
Golden Retriever: Question Retrieval System

Duplicate questions get posted on Q&A online forums because users may not be aware of similar questions. Our proposed system, Golden Retriever, can recommend existing questions that are semantically related to incoming questions. Compared with other existing techniques such as Latent Semantic Indexing, Language Model and Semantic Similarity, our approach shows good results for the ICHI Healthcare Data Analytics Challenge dataset using normalized TF-IDF, relevance heuristics, and semantic relatedness.
Revgest: augmenting gestural musical instruments with revealed virtual objects

Gestural interfaces, which make use of physiological signals, hand / body postures or movements, have become widespread for musical expression. While they may increase the transparency and expressiveness of instruments, they may also result in limited agency, for musicians as well as for spectators. This problem becomes especially true when the implemented mappings between gesture and music are subtle or complex. These instruments may also restrict the appropriation possibilities of controls, by comparison to physical interfaces. Most existing solutions to these issues are based on distant and/or limited visual feedback (LEDs, small screens). Our approach is to augment the gestures themselves with revealed virtual objects. Our contributions are, first a novel approach of visual feedback that allow for additional expressiveness, second a software pipeline for pixel-level feedback and control that ensures tight coupling between sound and visuals, and third, a design space for extending gestural control using revealed interfaces. We also demonstrate and evaluate our approach with the augmentation of three existing gestural musical instruments.
Neuropsychiatric disturbances in SLE are associated with antibodies against NMDA receptors

To determine whether neuropsychiatric manifestations in patients with systemic lupus erythematosus (SLE) are influenced by antibodies against the human N‐methyl‐d‐aspartate (NMDA) receptor types NR2a or NR2b. A decapeptide was synthesized containing a sequence motif present in the extracellular ligand‐binding domain of NMDA receptors NR2a and NR2b, bound by the monoclonal murine anti‐DNA antibody R4A. In an ELISA with the murine monoclonal R4v as positive control, plasma samples of 57 patients with SLE were examined for the anti‐peptide (anti‐NR2) antibody after the patients had been subjected to comprehensive psychological and cognitive testing. Poor performance on the Visual Paired Associates test (immediate), the Grooved Pegboard test, as well as high scores on the Beck Depression Inventory, and scales D‐2 (depression), Pd‐4 (psychopathic deviate), Sc‐8 (schizophrenia), and Ma‐9 (hypomania) of the MMPI‐2 were significantly associated with elevated levels of anti‐NR2 antibodies. The findings in several domains indicate an association between anti‐NR2 antibodies and depressed mood in addition to decreased short‐time memory and learning. Antibodies to NMDA receptors thus may represent one of several mechanisms for cerebral dysfunction in patients with SLE.