Miracle-dz/UniFAR-FTUs huggingface dataset:
Efficacy of Kami Guibi-tang as an Add-On Therapy to Acetylcholinesterase Inhibitor for Cognitive Function in Mild Alzheimer's Disease: A Pilot Study

Background Kami Guibi-tang (KGT), a traditional Korean herbal medicine is mainly used to treat insomnia and nervousness. Acetylcholinesterase inhibitors (AChEIs) are the main treatments for mild Alzheimer's disease (AD), a degenerative brain disease. However, currently no drug can fundamentally treat AD or reverse the advanced cognitive decline. This clinical study explored the efficacy and safety of adding KGT to AChEI for cognitive function in mild AD. Methods This was a pilot study for a larger randomized, double-blind, placebo-controlled trial. Participants between 55–90 years diagnosed with mild AD were recruited from Kyung Hee University Hospital at Gangdong, Seoul, Korea. They were randomized to receive either KGT or placebo for 24 weeks, in addition to their regular AChEI. The primary outcome was treatment efficacy, as assessed by the relative amount of change over the study period in total scores on the Dementia version of the Seoul Neuropsychological Screening Battery (SNSB-D). Changes in SNSB subscores were assessed as secondary outcomes. Safety parameters, including adverse events and abnormalities in blood tests, electrocardiograms, and brain magnetic resonance imaging were also monitored. Results Between March 2018 and November 2020, seven participants each in the KGT group and the placebo group completed the 24-week trial. There were no significant changes in SNSB-D total or subindex scores for either group (p = 0.69 and 0.63, respectively), and no significant differences were observed between them (p=0.71). No adverse events related to KGT were reported. We also compared and analyzed the results of a previous pilot study conducted on amnestic mild cognitive impairment (aMCI) using protocol of this study. The aMCI group showed a significant improvement in the total SNSB-D score, especially in the memory domain, compared to the mild AD group (p = 0.04 and 0.02, respectively). The Korean Mini-Mental State Exam and Korean Instrumental Activities of Daily Living scores also significantly improved in the aMCI group (p = 0.01 and 0.02, respectively). Conclusions Compared to placebo, adding KGT to AChEI did not significantly improve cognitive function in SNSB in patients with mild AD. We suggest that KGT would have a positive effect on patients with early stages of cognitive impairment such as aMCI. The findings could assist design larger, longer-term clinical trials of KGT use in elderly patients with mild AD. This study was registered in the Korean Clinical Trial Registry on December 26, 2017, with the CRIS approval number KCT0002904.
Molecular outflows associated with a flux-limited sample of bright far-infrared sources

Results of a systematic search for high-velocity CO emission from a sample of bright FIR sources from the IRAS Point Source Catalog are presented. This extends the original survey to a complete flux-limited sample. Results of CO mapping toward 22 FIR sources are given, showing that all of the sources are associated with strong CO emission that is peaked close to the FIR sources. Based on their IR colors and positional coincidence with strong CO emission, it is suggested that the sample is composed entirely of luminous, young stellar objects. New detections of molecular outflows were made toward six of the FIR sources. These outflows are relatively energetic, with typical mechanical energies of 10 to the 45th ergs. 30 refs.
Low-Grade Cervical Intraepithelial Neoplasia (CIN1) Evolution: Analysis of Opportunistic Preventive Vaccination Role

Background: Low-grade cervical lesions have a high percentage of clearance in young women, even if 71–82% of low-grade intraepithelial lesion/atypical squamous cells of undetermined significance (LSIL/ASCUS) reported a High-Risk Human Papillomavirus (HR-HPV) infection, which correlates with an increased risk of Cervical Intraepithelial Neoplasia (CIN)2+. The immunogenic effect of the anti-HPV vaccine appears to be significant. The aim of the study is to evaluate the effect, two years after the diagnosis, of the anti-HPV preventive vaccination on patients with low-grade cervical lesions. Methods: We collected clinical, colposcopic, histological, and virological data from patients aged 21–45 years who attended the colposcopy service of the department of Obsetrics and Gynecology of IRCCS Foundation Policlinico San Matteo, Pavia, Italy. In the 2005–2019 period and had a low-grade pap-smear. Results: We enrolled 422 women consecutively, divided into two groups (vaccinated and not vaccinated) for the retrospective analysis. The rate of persistence and progression of CIN were higher in the not-vaccinated group (p = 0.019). The relative risk (RR) to develop CIN2+ during follow-up vs. the the CIN1 persistence was 1.005 (95% Confidence Interval—CI 0.961–1.051) vs. 0.994 (95% CI 0.994–1.018) for age, 3.472 (95% CI 1.066–11.320) vs. 1.266 (95% CI 0.774–2.068) for non-vaccinated, 0.299 (95% CI 0.088–1.018) vs. 0.518 (95% CI 0.242–1.109) for HIV status negative, respectively. Analyzing the time to negativity, the odds ratio (OR) was 1.012 (95% CI 1–1.024) for age and 1.591 (95% CI 1.223–2.069) for vaccination; on the other hand, considering the relationship between the time to negative and the HPV genotypes contained in the 9-valent HPV vaccines, the OR was 1.299 (95% CI 1.026–1.646) for at least one of these at recruitment and 0.631 (95% CI 0.471–0.846) at follow-up. Furthermore, the presence of at least one of the HPV genotypes targeted by the HPV nonavalent vaccine is a key indicator of the risk of progression to CIN2+: OR was 3.443 (95% CI 1.065–11.189) for the presence of at least one HPV genotype at enrollment and 5.011 (95% CI 1.899–13.224) for the presence of at least one HPV genotype at follow-up, respectively. Conclusions: We reported in a retrospective study the benefit of anti-HPV vaccination in promoting negativity and increasing low-grade cervical lesions regression.
In-Situ Deformation of Tungsten Single Crystals with [100] Tensile Axis in an Ultra-High Voltage Electron Microscope

At an early stage of deformation, only one slip system is activated in local region, and very straight screw dislocations are dominant as a whole. These screw dislocations move slowly and make cross-slip frequently. On the other hand, the edge dislocations move flexibly with high speed and escape out from the specimen as soon as they are multiplied from the dislocation sources. As the plastic deformation proceeds, two families of slip systems are activated considerably even in the localized regions, and cross grids of screw dislocations are formed all over the specimen. Each of these composite dislocations move slowly and the spacing of dislocations decreases with increasing strain. After that, dislocation tangles are frequently formed in the cross grids of dislocations by group of moving dislocations. These data are compared with those in the specimens with [110] tensile axis, and deformation mechanism of tungsten was discussed.
Transient thermocapillary flow in thin liquid layers

A spatially varying temperature distribution imposed on the free surface of a liquid leads to an effective tractive force on the surface because of the dependence of surface tension on temperture. A solution for transient flow in infinite thin layers is presented. The layer is thin enough so that inertial forces are negligible. The equations of motion are nondimensionalized by an explicit scaling procedure. Small‐time and large‐time solutions are obtained with variation of surface height as part of the solution.
A numerical scheme for shock propagation in three dimensions

A numerical scheme for shock propagation in three space dimensions is presented. The motion of the leading shock surface is calculated by using Whitham’s theory of geometrical shock dynamics. The numerical scheme is used to examine the focusing of initially curved shock surfaces and the diffraction of shocks in a pipe with a 90° bend. Numerical and experimental results for the corresponding two-dimensional or axi-symmetrical cases are used to compare with the new and more complicated three-dimensional results.
T Cell Energy Metabolism Is a Target of Glucocorticoids in Mice, Healthy Humans, and MS Patients

Glucocorticoids (GCs) are used to treat inflammatory disorders such as multiple sclerosis (MS) by exerting prominent activities in T cells including apoptosis induction and suppression of cytokine production. However, little is known about their impact on energy metabolism, although it is widely accepted that this process is a critical rheostat of T cell activity. We thus tested the hypothesis that GCs control genes and processes involved in nutrient transport and glycolysis. Our experiments revealed that escalating doses of dexamethasone (Dex) repressed energy metabolism in murine and human primary T cells. This effect was mediated by the GC receptor and unrelated to both apoptosis induction and Stat1 activity. In contrast, treatment of human T cells with rapamycin abolished the repression of metabolic gene expression by Dex, unveiling mTOR as a critical target of GC action. A similar phenomenon was observed in MS patients after intravenous methylprednisolon (IVMP) pulse therapy. The expression of metabolic genes was reduced in the peripheral blood T cells of most patients 24 h after GC treatment, an effect that correlated with disease activity. Collectively, our results establish the regulation of T cell energy metabolism by GCs as a new immunomodulatory principle.
Netflix and cringe – affectively watching ‘uncomfortable’ TV

In this study, we conceptualise the phenomenon of cringe watching in order to understand why and how consumers engage with media that make them uncomfortable. We mobilise de-Western feminist thought to analyse our reactions to the Netflix series Indian Matchmaking. We find that ‘cringe’ is a bundle of consumers’ ‘ugly feelings’ belying complicated affect and biases that are often rooted in Western values. By leveraging collaborative autoethnography as our method, we allow space for both ‘visceral’ and ‘rational’ experiences, challenging the role of researchers as subjects by positioning ourselves, additionally, as objects. Our findings reveal that engaging with media artefacts is a recursive process wherein consumers may encounter ‘cringe’, which when subject to introspection reveals unexpected socio-affective states like self-compassion, empathy for others, and understanding their own limitations as well as their place in the world. These findings have implications for marketing and consumer research on media, representation, and affect.
Reduction of Lams-Related Adverse Events with Accumulating Experience in a Large-Volume Tertiary Referral Center

Background and aims: Lumen-apposing metal stents (LAMSs) are increasingly used both for on- and off-label indications. We continuously adapt our step-by-step protocol to optimize the safe deployment of LAMSs for the different indications. The aim of this study was to evaluate the impact of this approach over time. Methods: We conducted a single-center study on consecutive patients who underwent LAMS placement for on- and off-label indications between June 2020 and June 2022. Endpoints included technical success, clinical success and adverse event rates. We compared the results with our previously published early experience with LAMSs (N = 61), between March 2018 and May 2020. Results: This cohort consisted of 168 LAMSs in 153 patients. Almost half of them (47.6%) were placed for off-label indications (gastro-enterostomy, temporary access to the excluded stomach in patients with previous gastric bypass, drainage of postsurgical collections, stenting of short refractory gastrointestinal strictures). While the technical and clinical success rates were similar to those in our previously published cohort (97% and 93.5% versus 93.4% and 88.5%, respectively), the adverse event rate dropped from 21.3% to 8.9%. Conclusions: Our results demonstrate the impact of a learning curve in LAMS placement, with a clinically relevant drop in LAMS-related adverse events over time.
Unsteady three-dimensional marginal separation caused by surface-mounted obstacles and/or local suction

Earlier investigations of steady two-dimensional marginally separated laminar boundary layers have shown that the non-dimensional wall shear (or equivalently the negative non-dimensional perturbation displacement thickness) is governed by a nonlinear integro-differential equation. This equation contains a single controlling parameter $\Gamma$ characterizing, for example, the angle of attack of a slender airfoil and has the important property that (real) solutions exist up to a critical value $\Gamma_c$ of $\Gamma$ only. Here we investigate three-dimensional unsteady perturbations of an incompressible steady two-dimensional marginally separated laminar boundary layer with special emphasis on the flow behaviour near $\Gamma_c$. Specifically, it is shown that the integro–differential equation which governs these disturbances if $\Gamma_c\,{-}\,\Gamma\,{=}\,O(1)$ reduces to a nonlinear partial differential equation – known as the Fisher equation – as $\Gamma$ approaches the critical value $\Gamma_c$. This in turn leads to a significant simplification of the problem allowing, among other things, a systematic study of devices used in boundary-layer control and an analytical investigation of the conditions leading to the formation of finite-time singularities which have been observed in earlier numerical studies of unsteady two-dimensional and three-dimensional flows in the vicinity of a line of symmetry. Also, it is found that it is possible to construct exact solutions which describe waves of constant form travelling in the spanwise direction. These waves may contain singularities which can be interpreted as vortex sheets. The existence of these solutions strongly suggests that solutions of the Fisher equation which lead to finite-time blow-up may be extended beyond the blow-up time, thereby generating moving singularities which can be interpreted as vortical structures qualitatively similar to those emerging in direct numerical simulations of near critical (i.e. transitional) laminar separation bubbles. This is supported by asymptotic analysis.
A Colorimetric Method for the Rapid Estimation of the Total Cannabinoid Content in Cannabis Samples

A colorimetric method for the estimation of the total content of cannabinoids in cannabis samples is proposed. The assay is based on the reaction of these compounds with the reagent Fast Blue B (FBB), which has been immobilized into polydimethylsiloxane (PDMS). The reaction and detection conditions have been established according to the results obtained for the individual cannabinoids Δ9-tetrahydrocannabidiol (THC), cannabidiol (CBD), and cannabinol (CBN), as well as for ethanolic extracts obtained from cannabis samples after ultrasonication. In contact with the extract and under basic conditions, the reagent diffuses from the PDMS device, producing a red-brown solution. The absorbances measured at 500 nm after only 1 min of exposure to the FBB/PDMS composites led to responses proportional to the amounts of the cannabinoids in the reaction media. Those absorbances have been then transformed in total cannabinoid content using CBD as a reference compound. The potential utility of the proposed conditions has been tested by analyzing different cannabis samples. The selectivity towards other plants and drugs has been also evaluated. The present method is proposed as a simple and rapid alternative to chromatographic methods for the estimation of the total content of cannabinoids.
Photocatalytic Activity of CoO/ZnO Nanocrystalline for Dye Wastewater Treatment under UV Light

CoO nanocrystal is well-known photocatalyst for overall water splitting. However it suffers from a very short lifetime of only 1 h. The poor stability is derived from carrier recombination-induced thermal oxidation. This research will provide information about synthesis of CoO/ZnO nanocrystalline that can potentially enhance photocatalysts. CoO has been synthesized first under hydrothermal method, followed by calcination process. Thereafter, CoO has been used to produce CoO/ZnO under precipitation method. The samples were characterized using XRD (X-Ray Diffraction), FTIR (Fourier Transform Infrared Spectroscopy), and UV-VIS (UV–Visible Spectroscopy) to analyze their composition, chemical functional group, optical absorption, and band gap. The XRD spectrum showed that CoO/ZnO had cubic spinel and hexagonal phase structure with crystallite size of 69.0, 46.4, 32.8, and 32,4 nm. The bands in obtained FTIR spectrum at 586.36, 671.23, and 410-429 cm−1 were correlated with vibrations of the Co3+ in octahedral hole, the Co2+ in tetrahedral hole, and Zn-O, respectively. The band gap energy of CoO, CoO/ZnO with variation of 1:1 and 1:3 were 4.39, 4.14, and 3.65 eV, respectively. The photocatalytic activities of CoO/ZnO were confirmed by methylene blue dyes photodegradation of 663 nm under UV light irradiation in aqueous solution. The 22.4% methylene blue can be removed within 3 h. Overall, these findings reveal the potential of CoO/ZnO for practical application.
Kinetic theory boundary conditions for discrete velocity gases

Boundary conditions are investigated for a model gas composed of identical particles with velocities restricted to a given finite set of vectors. A possible model of the gas surface interaction is given and an H theorem for a gas in a vessel is obtained. Then, the steady Couette flow between two parallel plates is studied. The model with four coplanar velocities is used and the velocity set has arbitrary orientation. The exact kinetic solution is compared with the solutions of the associated Navier–Stokes problems.
Lagrangian Transport Calculations Using UARS Data. Part I. Passive Tracers

Abstract The transport of passive tracers observed by the Upper Atmosphere Research Satellite is simulated using computed three-dimensional trajectories of ≈ 100 000 air parcels initialized on a stratosphere grid, with horizontal winds provided by the United Kingdom Meteorological Office data assimilation system, and vertical (cross isentropic) velocities computed using a fast radiation code. The conservative evolution of trace constituent fields is estimated over 20–30-day periods by assigning to each parcel the observed mixing ratio of the long-lived trace gases N20 and CH4 observed by the Cryogenic Limb Army Etalon Spectrometer (CLAES) and H2O observed by the Microwave Limb Sounder (MLS) on the initialization date. Agreement between calculated and observed fields is best inside the polar vortex and is better in the Arctic than in the Antarctic. Although there is not always detailed agreement outside the vortex, the trajectory calculations still reproduce the average large-scale characteristics of passi.
Genetic Diversity and Population Structure of a Wide Pisum spp. Core Collection

Peas (Pisum sativum) are the fourth most cultivated pulses worldwide and a critical source of protein in animal feed and human food. Developing pea core collections improves our understanding of pea evolution and may ease the exploitation of their genetic diversity in breeding programs. We carefully selected a highly diverse pea core collection of 325 accessions and established their genetic diversity and population structure. DArTSeq genotyping provided 35,790 polymorphic DArTseq markers, of which 24,279 were SilicoDArT and 11,511 SNP markers. More than 90% of these markers mapped onto the pea reference genome, with an average of 2787 SilicoDArT and 1644 SNP markers per chromosome, and an average LD50 distance of 0.48 and 1.38 Mbp, respectively. The pea core collection clustered in three or six subpopulations depending on the pea subspecies. Many admixed accessions were also detected, confirming the frequent genetic exchange between populations. Our results support the classification of Pisum genus into two species, P. fulvum and P. sativum (including subsp. sativum, arvense, elatius, humile, jomardii and abyssinicum). In addition, the study showed that wild alleles were incorporated into the cultivated pea through the intermediate P. sativum subsp. jomardii and P. sativum subsp. arvense during pea domestication, which have important implications for breeding programs. The high genetic diversity found in the collection and the high marker coverage are also expected to improve trait discovery and the efficient implementation of advanced breeding approaches.
Two Distinct Ancient Components in the Sculptor Dwarf Spheroidal Galaxy: First Results from the Dwarf Abundances and Radial Velocities Team

We have found evidence for the presence of two distinct ancient stellar components (both ≥10 Gyr old) in the Sculptor dwarf spheroidal galaxy. We used the ESO Wide Field Imager in conjunction with the Very Large Telescope/FLAMES spectrograph to study the properties of the resolved stellar population of Sculptor out to and beyond the tidal radius. We find that two components are discernible in the spatial distribution of horizontal branch stars in our imaging and in the [Fe/H] and vhel distributions for our large sample of spectroscopic measurements. They can be generally described as a "metal-poor" component ([Fe/H] < -1.7) and a "metal-rich" component ([Fe/H] > -1.7). The metal-poor stars are more spatially extended than the metal-rich stars, and they also appear to be kinematically distinct. These results provide insight into the formation processes of small systems in the early universe and the conditions found there. Even this simplest of galaxies appears to have had a surprisingly complex early evolution.
Predictive Value of Red Cell Distribution Width in the Diagnosis of Peripherally Inserted Central Catheter (PICC)-Related Thrombosis Among Cancer Patients

Purpose This study aimed to investigate the predictive value of red cell distribution width (RDW) in patients with peripherally inserted central catheter (PICC)-related thrombosis. Patients and methods This was a case‒control study. A total of 98 cancer patients undergoing PICC placement from January 2017 to December 2019 at the ICU Venous Access Center of Peking University Cancer Hospital were retrospectively analyzed. These included 47 cases in the thrombosis group and 51 cases in the nonthrombosis group according to the occurrence of PICC-related thrombosis within 90 days after the PICC procedure. Results a) RDW was significantly higher in the thrombosis group (15.98±1.93) than in the nonthrombosis group (13.98±1.09). Additionally, the number of smoking histories in the thrombosis group (18, 38.30%) was significantly higher than that in the nonthrombosis group (5, 9.80%). b) Logistic regression analysis indicated that RDW and smoking history were independent risk factors for PICC-related thrombosis (OR: 3.028, P<0.001; OR: 5.640, P=0.023). c) The area under the receiver operating characteristic (ROC) curve of the combination of RDW and smoking history was 86.8%, and the sensitivity and specificity for predicting thrombosis after PICC were 85.1% and 80%, respectively. d) Cox regression analysis revealed that RDW and smoking history were independent risk factors for PICC-related thrombosis (p<0.001). e) Results from Kaplan‒Meier analysis showed that incidence of PICC-related thrombosis in patients with RDW less than 14.75% is significantly lower than those with RDW 14.75% and above (p<0.001). e) Baseline RDW was not different between the two groups (P>0.05), ΔRDW was significantly different between the two groups (p<0.001). Conclusion The combined use of RDW and smoking history has early evaluation and predictive value in the diagnosis of PICC-related thrombosis.