Miracle-dz/UniFAR-FTUs huggingface dataset:
Assisted reproductive technologies (ART) and placental abnormalities

Abstract Objectives Assisted reproductive technologies (ART) may be associated with placental abnormalities including placenta previa, umbilical cord abnormalities, and placental abruption. Our study evaluates the relationship between ART and placental abnormalities compared with spontaneously conceived controls. Methods An IRB-approved cohort study was conducted including women who delivered between January 2013 and December 2018. We excluded delivery prior to 23 weeks and known fetal anomalies. Patients were matched with controls (2:1) for parity, age, and mode of delivery. Controls were women who had spontaneously conceived and delivered immediately preceding and following the index delivery. The primary outcome was placental abnormalities found on both antenatal ultrasound and pathology in ART gestations compared with spontaneously conceived gestations. Results There were 120 ART pregnancies and 240 matched control pregnancies identified. The groups were similar for parity, BMI, comorbidities, number of multiples, mode of delivery, and female newborns. The ART group had a higher maternal age (37.1±5 y vs. 30.0±5 y; p<0.001), greater preterm birth (29 vs. 6%; p<0.001), and lower BW (2,928±803 g vs. 3,273±586 g; p<0.001). The ART group had a higher incidence of placenta previa on ultrasound (4.0 vs. 0.4%, p=0.01), adherent placentas at delivery (3 vs. 0% p=0.014), placental abruption (2 vs. 0%; p=0.04), as well as an increased rate of velamentous cord insertion (12 vs. 3%, p<0.001) and marginal cord insertion (28 vs. 15%, p=0.002). ART demonstrated a two-fold likelihood of abnormal placental pathology. Conclusions ART is associated with increased rate of placental abnormalities, including abnormal umbilical cord insertion and increased rates of adherent placentation. This information may be beneficial in planning and surveillance in patients with ART pregnancies.
Personality Types and Student Performance in an Introductory Physics Course.

We measured the personality type of the students in a large introductory physics course of mostly life science students using the True Colors instrument. We found large correlations of personality type with performance on the precourse Force Concept Inventory (FCI), both term tests, the postcourse FCI, and the final examination. We also saw correlations with the normalized gain on the FCI. The personality profile of the students in this course is very different from the profile of the physics faculty and graduate students, and also very different from the profile of students taking the introductory physics course intended for physics majors and specialists.
Use of a Servo-Controlled Cooling Gel Pad System to Regulate Body Temperature in Critically Ill Children

Objectives: To assess the efficacy and safety of a servo-controlled cooling pad system for target temperature management in critically ill pediatric patients. Design: A prospective, single-center, observational study. Setting: PICU of a tertiary hospital from September 2018 to September 2019. Patients: Children from 28 days to 16 years old subjected to servo-controlled body temperature control. Methods: The Arctic Sun 5000 system (Bard Medical, Covington, GA) and Arctic Gel Hydrogel pads were used for the purposes of the study. Data collected included demographics, indication of therapy, patient’s body temperature, target temperature, time-to-target temperature, duration of therapy, and need to start or increase sedation and/or muscle relaxants. Measurements and Main Results: A total of 16 patients were included, of whom 68.8% were male; mean age was 4.7 years. The most frequent indication was fever associated with hemodynamic instability (62.5%). The target temperature was normothermia (36 or 36.5°C) in 81% of cases. Mean baseline body temperature was 37.6°C (± 1.2°C), and 50% of patients had fever (> 38°C). The mean speed of cooling was 1.2°C/hr (± 1°C/hr). Mean time to target temperature was 118 minutes (± 98.8 min). Mean duration of therapy was 68.7 hours (± 58.3 hr). Two patients had fever related to device disconnection during the treatment. At the start of the therapy, 15 patients were receiving sedative and analgesic drugs, and four received muscle relaxants. A patient required increased sedation, whereas another patient needed to start muscle relaxants. One of the patients developed a skin lesion in the axilla, no other adverse events were registered. Conclusions: Despite the small sample size, the results of the study showed that target temperature management by the servo-controlled gel pad system in critically ill pediatric patients was effective in achieving satisfactory temperature control and it was well-tolerated.
Activation of glucagon‐like peptide‐1 receptors and skilled reach foraging

Glucagon‐like peptide‐1 receptor (GLP‐1R) agonists, such as exendin‐4 (Ex4), liraglutide and dulaglutide, regulate glucose homeostasis and are thus used to treat diabetes type II. GLP‐1 also contributes towards a variety of additional physiological functions, including suppression of reward and improvement of learning. Acute activation of GLP‐1R in the nucleus accumbens (NAc) shell, an area essential for motivation, reduces the motivation to consume sucrose or alcohol when assessed in a simple motor task. However, the effects of repeated administration of the different GLP‐1R agonists on behaviours in a more complex motor task are unknown. The aim was therefore to investigate the effects of repeated Ex4, liraglutide or dulaglutide on the motivation and learning of a complex motor tasks such as skilled reach foraging in the Montoya staircase test. To explore the neurophysiological correlates of the different GLP‐1R agonists on motivation, ex vivo electrophysiological recordings were conducted. In rats with an acquired skilled reach performance, Ex4 or liraglutide but not dulaglutide reduced the motivation of skilled reach foraging. In trained rats, Ex4 infusion into NAc shell decreased this motivated behaviour, and both Ex4 and liraglutide supressed the evoked field potentials in NAc shell. In rats without prior Montoya experience, dulaglutide but not Ex4 or liraglutide enhanced the learning of skilled reach foraging. Taken together, these findings indicate that the tested GLP‐1R agonists have different behavioural outcomes depending on the context.
Some φ-Fixed Point Results for (F,φ,α-ψ)-Contractive Type Mappings with Applications

In this paper, we introduce the notions of (F, φ , α - ψ )-contractions and (F, φ , α - ψ )-weak contractions in metric spaces and utilize the same to prove some existence and uniqueness φ -fixed point results. Some illustrative examples are given to demonstrate the usefulness and effectiveness of our results. As applications, we deduce some fixed point theorems in partial metric spaces besides proving an existence result on the solution of nonlinear differential equations. Our results extend, generalize and improve some relevant results of the existing literature.
The Effect of Infrared Light’s Power on the Infrared Spectra of Thin Films

There are numerous evidences that a relationship exists between the average power P of electromagnetic waves and the mechanical motion of the objects interacting with them. We investigate the effects of infrared (IR) light’s average power P on the transmission Fourier transform infrared (FTIR) spectra of thin cubic Yb2O3 and rhombohedral LaAlO3 films deposited on silicon via atomic layer deposition. We find that different values of P of the IR light displace the minima of the absorption bands. This effect is reproducible in different sets of experiments and in different spectrometers. To interpret the experimental findings, we use the law of conservation of energy. We find a correlation among the energy of the IR waves and the number, moment of inertia, and vibrational/rotational frequency of the bonds involved in the vibrational or rotational motion. The law of conservation of energy unveils that larger values of P of the IR light and lower wavenumbers of the resonances involve a larger number of crystal bonds. One practical application of our approach is that it suggests a way to improve the sensitivity of the FTIR spectra of thin crystalline films in the far IR region.
Investigating primary preservice teachers’ ultraviolet radiation awareness and perceived ability to teach sun safety

Abstract Issue addressed Sun protection practices in Australian primary schools remain inconsistent. Therefore, this study investigates primary PSTs sun protective sun behaviours, ultraviolet (UV) radiation awareness and perceived ability to teach sun safety. Methods A convenience sample of undergraduate PSTs (N = 275; mean age = 23.13 years) enrolled at one Western Australian university completed an online survey. Descriptive analyses provided features of the data. Factors associated with sun protection behaviours and perceived knowledge and skill to teach sun safety were explored using multivariable logistic regression models. Results Lesser than 10% of participants reported using sun protective measures daily (midday shade use: 6.5%; sunscreen: 7.6%; hat: 4.4%). Only 56.3% reported they understand the UV index, with 68.0% rarely/never using it to aid sun protection. Under half the participants reported they felt they had the knowledge (38.5%) or skills (40%) to effectively teach sun safety in primary schools. Regression analysis revealed gender, undergraduate, year and skin sensitivity were not predictors of UV index use (P > .05) or perceived knowledge of sun safety (P > .05). Skin sensitivity was the strongest predictor for shade usage (P = .02), hat usage (P = .05) and perceived skill to teach sun safety (P = .02). Conclusions Survey data indicate UV radiation is inconsistently understood by PSTs. Many felt that they did not have the required knowledge or skill to teach sun safety effectively. So what? Improving PSTs UV radiation knowledge while at university is a potential opportunity to improve sun safety delivery in primary schools. A targeted intervention for PSTs is warranted.
Sex Hormones and Incident Heart Failure in Men and Post-Menopausal Women: The Atherosclerosis Risk in Communities Study.

CONTEXT Sex differences exist in heart failure (HF) phenotypes, but there is limited research on the role of sex hormones in HF and its subtypes. OBJECTIVE To examine the associations of total testosterone, dehydroepiandrosterone sulfate (DHEA-S), and sex hormone binding globulin (SHBG) with incident HF, HF with preserved ejection fraction (HFpEF), and HF with reduced ejection fraction (HFrEF). DESIGN Atherosclerosis Risk in Communities (ARIC) study (prospective cohort study). Median follow-up is 19.2 years. SETTING General community. PARTICIPANTS 4,107 men and 4,839 post-menopausal women, with mean age of 63.2 (SD 5.7) and 62.8 (5.5) years, respectively. EXPOSURE Plasma sex hormone levels were measured at Visit 4 (1996-1998). MAIN OUTCOME MEASURES Incident HF events were identified through hospital discharge codes and death certificates. RESULTS The HRs for HF associated with 1 SD decrease in log-transformed total testosterone, DHEA-S, and SHBG were 1.10 (95% CI 1.03, 1.17), 1.07 (1.00, 1.15), and 1.04 (0.96, 1.11) in men, and 1.05 (0.99, 1.13), 1.17 (1.09, 1.24), and 0.93 (0.85, 1.01) in women, respectively. The associations between sex hormones with subtypes of HF had similar patterns but were attenuated and became statistically insignificant. CONCLUSION In this prospective cohort, lower levels of endogenous testosterone and DHEA-S in men, and DHEA-S in post-menopausal women, were associated with the development of HF. Similar directions of association in both sexes and both HF subtypes suggest that sex hormones play a role in the development of HF through common pathways regardless of sex.
The Effect of Age on Short- and Long-Term Outcomes in Patients With Pancreatic Ductal Adenocarcinoma Undergoing Laparoscopic Pancreaticoduodenectomy

Objective The aim of the study was to evaluate the effect of age on outcomes with pancreatic ductal adenocarcinoma (PDAC) undergoing laparoscopic pancreaticoduodenectomy (LPD). Methods We retrospectively collected clinical data of consecutive patients with PDAC undergoing LPD from January 2012 to April 2019. The patients were divided into 2 groups according to age at admission for LPD: younger than 70 and 70 years or older. Results A total of 147 patients were included (<70 years, n = 96; ≥70 years, n = 51). The elderly LPD patients had lower serum albumin levels (mean, 37.9 [standard deviation, 4.8] g/L vs 40.7 [standard deviation, 6.8] g/L, P = 0.004) and a larger frequency of comorbidities (62.7% vs 36.5%, P = 0.002) than younger patients. The short-term outcomes showed no significant differences. The median overall survival time of the younger patients was not significantly greater than that of the elderly patients (20.0 [95% confidence interval, 16.1–23.9] months vs 19.0 [95% confidence interval, 13.8–24.2] months, P = 0.902). Conclusions The short- and long-term outcomes of elderly patients with PDAC after LPD were similar to those of younger patients, despite a higher prevalence of multiple chronic illnesses and poorer nutritional conditioning among the elderly patients. These results show that LPD can be applied safely to elderly patients.
Quantitative Results of Perfusion Utilising Hyperspectral Imaging on Non‐diabetics and Diabetics: A Pilot Study

There is a paucity of quantitative measures of microvascular perfusion values in the skin. Newly developed, handheld hyperspectral imaging devices identify unique spectral fingerprints of oxygenated and deoxygenated haemoglobin in the superficial microvasculature. Establishing value ranges for healthy patients without vascular complications will subsequently help standardise assessments for perfusion defects. In particular, diabetics who are prone to vascular calcifications and lower extremity wounds may benefit. A total of 73 subjects were enrolled in the study and split in two cohorts: 36 ‘non‐diabetic’ non‐vascularly compromised patients and 37 ‘diabetic’ patients with a formal diagnosis of diabetes but without history of pedal ulceration. Values of oxygenated haemoglobin (HT‐Oxy) and deoxygenated haemoglobin (HT‐DeOxy) from both devices are analysed.
The Relativistic Geometry of the Complex Matter Space

Duality behavior of photons in wave-particle property has posed challenges and opportunities to discover other frontiers of fundamental particles leading to the relativistic and quantum description of matter. The speed of particles faster than the speed of light could not be recognized, and matter was always described as a real number. A new fundamental view on matter as a complex value has been introduced by many authors who present a paradigm that is shifted from real or pure imaginary particles to Complex Matter Space. A new assumption will be imposed that matter has two intrinsic components: i) mass, and ii) charge. The mass will be measured by real number systems and charged by an imaginary unit. The relativistic concept of Complex Matter Space on energy and momentum is investigated and we can conclude that the new Complex Matter Space (CMS) theory will help get one step closer to a better understanding toward: 1) Un-Euclidean description of Minkowski Geometry in the context of the Complex Matter Space, 2) transformation from Euclidean to Minkowski space and its relativistic interpretation. Finally, geometrical foundations are essential to have a real picture of space, matter, and the universe.
Precarious Employment as Compared to Unemployment Reduces the Risk of Depression in the Elderly in Korea.

OBJECTIVE To compare how depression develops in precarious employment and in unemployment, as how precarious jobs impact unemployment-related depression is relatively unknown. METHODS Using the 1st-4th Korean Longitudinal Study of Aging survey data, 5,638 older people were analyzed to measure depression incidence in relation to employment status. A Center for Epidemiological Studies-Depression Scale form was chosen to identify depression. Hazard ratios (HRs) and 95% confidence intervals (CIs) were derived from Cox proportional hazards models adjusted for a number of variables. RESULTS Unemployment-related depression risk was significantly higher than for precarious employment. Depression risk was significantly lower for male full-time permanent workers than precarious workers, but was not significantly different in women. CONCLUSIONS To prevent the deterioration of mental health in the elderly, an extensive job promotion campaign including precarious work is required.
Integrated omics analysis reveals the alteration of gut microbe-metabolites in obese adults

Obesity, a risk to health, is a global problem in modern society. The prevalence of obesity was approximately 13% among world's adult population. Recently, several reports suggested that the interference of gut microbiota composition and function is associated with metabolic disorders, including obesity. Gut microbiota produce a board range of metabolites involved in energy and glucose homeostasis, leading to the alteration in host metabolism. However, systematic evaluation of the relationship between gut microbiota, gut metabolite and host metabolite profiles in obese adults is still lacking. In this study, we used comparative metagenomics and metabolomics analysis to determine the gut microbiota and gut-host metabolite profiles in six normal and obese adults of Chinese origin, respectively. Following the functional and pathway analysis, we aimed to understand the possible impact of gut microbiota on the host metabolites via the change in gut metabolites. The result showed that the change in gut microbiota may result in the modulation of gut metabolites contributing to glycolysis, tricarboxylic acid cycle and homolactic fermentation. Furthermore, integrated metabolomic analysis demonstrated a possible positive correlation of dysregulated metabolites in the gut and host, including l-phenylalanine, l-tyrosine, uric acid, kynurenic acid, cholesterol sulfate and glucosamine, which were reported to contribute to metabolic disorders such as obesity and diabetes. The findings of this study provide the possible association between gut microbiota-metabolites and host metabolism in obese adults. The identified metabolite changes could serve as biomarkers for the evaluation of obesity and metabolic disorders.
Prevalence, antibiotic susceptibility and characterization of Vibrio parahaemolyticus isolates in China.

Vibrio parahaemolyticus is a marine and estuarine bacterium that poses a major threat to human health worldwide. In this study, from 2017 to 2019, we evaluated 900 food samples collected from China in 2017, with an aimed to determine the incidence and features of V.parahaemolyticus in ready-to-eat (RTE) foods, shrimp and fish in China. The contamination rates in these were 3.67%, 19.33%, and 10.67%, respectively. and the prevalence of V.parahaemolyticus was higher in summer than in winter. In addition, 101 V.parahaemolyticus strains were isolated. Our results suggested that most of the isolates were resistant to aminoglycosides base on the antimicrobial resistance patterns of these aquatic product isolates against 14 antimicrobial agents. Furthermore, most of the isolates were multidrug-resistant. Serotyping showed that the isolates of the O2 serotype comprised the maximum proportion. ERIC-PCR results indicated that the isolates (n = 101) could be classified into 12 clusters. There were 82 STs suggesting genetic variation and relatedness among these isolates. Our findings demonstrated the presence of V.parahaemolyticus in foods from Chinese retail markets, and show that this methodology can be used for microbiological risk assessment in China.
Concentration, ellipsoidal collapse, and the densest dark matter haloes

The smallest dark matter haloes are the first objects to form in the hierarchical structure formation of cold dark matter (CDM) cosmology and are expected to be the densest and most fundamental building blocks of CDM structures in our universe. Nevertheless, the physical characteristics of these haloes have stayed illusive, as they remain well beyond the current resolution of N-body simulations (at redshift zero). However, they dominate the predictions (and uncertainty) in expected dark matter annihilation signal, amongst other astrophysical observables. Using the conservation of total energy and the ellipsoidal collapse framework, we can analytically find the mean and scatter of concentration $c$ and 1-D velocity dispersion $\sigma_{\rm 1d}$ for haloes of different virial mass $M_{200}$. Both $c$ and $\sigma_{\rm 1d}/M_{200}^{1/3}$ are in good agreement with numerical results within the regime probed by simulations -- slowly decreasing functions of mass that approach constant values at large masses. In particular, the predictions for the 1-D velocity dispersion of cluster mass haloes are surprisingly robust as the inverse heat capacity of cosmological haloes crosses zero at $M_{200} \sim 10^{14} M_\odot$. However, we find that current extrapolations from simulations to smallest CDM haloes dramatically depend on the assumed profile (e.g. NFW vs. Einasto) and fitting function, which is why theoretical considerations, such as the one presented here, can significantly constrain the range of feasible predictions.
Growth hormone stimulates ad ipogenesis of 3 T 3L 1 cells through activation of the Stat 5 A / 5 B-PPAR g pathway

Growthhormone-deficient (GHD)patients showadecreasednumber of adipocytes,which isnormalizedbyGHreplacement, indicating an adipogenic effect of GH. However, the precise mechanisms underlying this effect remain to be clarified. In this study, we investigated the adipogenic effect of GH. GH stimulated MDI (3-isobutyl-1-methylxanthine, dexamethasone, and insulin)-induced adipogenesis of 3T3-L1 cells with early induction of peroxisome proliferator-activated receptors (PPAR)g2 expression. This adipogenic effect of GH was suppressed by overexpression of Stat5A mutant (Stat5A-Y694F), a transcriptional suppressor for the GH–Stat5A/5B signaling pathway, with the reduction of PPARg2 expression. Next, we investigated the relationshipbetweenStat5A/5BandCCAAT/enhancerbindingprotein (C/EBP)b/dorPPARg in3T3-L1cells. Stat5A/5B stimulated C/EBPband C/EBPd-induced adipogenesis with enhancement of PPARg2 expression. In addition, Stat5A/5B enhanced the transcriptional activity of C/EBPb/d in the PPARg gene promoter. Furthermore, Stat5A/5B stimulatedPPARg-inducedadipogenesis and enhanced the transcriptional activity ofPPARg. These results suggest that the GH–Stat5A/5B signaling pathway stimulates adipogenesis in cooperation with C/EBPb/d and PPARg. To completely understand the effect of GH, cDNAmicroarray analysis was performed to screen genes affected byGH duringMDI-induced adipogenesis. Among 4277 genes, 18 and 19 genes were upand down-regulated respectively. cDNA microarray analysis also indicated the up-regulation of PPARg and the modulation of expression of genes coding for growth factors or growth factor receptors, suggesting thatGHstimulatesadipogenesis inassociationwith themodulationof cell growth. Thus, theGH– Stat5A/Bsignaling pathwaystimulatesadipogenesis through twodistinct steps. In addition, cDNAmicroarray dataprovide us the further insights underlying the adipogenic effect of GH. Journal of Molecular Endocrinology (2007) 38, 19–34