Miracle-dz/UniFAR-FTUs huggingface dataset:
Heparin dosing in uninterrupted anticoagulation with dabigatran vs. warfarin in atrial fibrillation ablation: RE-CIRCUIT study

Abstract Aims To describe heparin dosing requirements in patients who underwent catheter ablation of atrial fibrillation with uninterrupted anticoagulation using dabigatran etexilate (dabigatran) or warfarin to attain therapeutic activated clotting time (ACT) in the RE-CIRCUIT® study. The RE-CIRCUIT study showed significantly fewer major bleeding events in the dabigatran vs. warfarin treatment group. Unfractionated heparin was administered during the procedure to maintain ACT >300 s. Methods and results Patients were randomly assigned to dabigatran 150 mg bid or international normalized ratio-adjusted warfarin. Ablation was performed with uninterrupted anticoagulation and continued for 8 weeks after the procedure. Heparin was administered after placement of femoral sheaths before or immediately after transseptal puncture. Ablation was performed in 635 patients (dabigatran, 317; warfarin, 318); data were available from 396 patients administered heparin (dabigatran, 191; warfarin, 205). Most frequent time window from last dose of study drug to septal puncture was 0 to <4 h in the dabigatran (41.3%) and 16 to <24 h in the warfarin arms (44.7%). Overall mean (standard deviation) heparin dose was similar between the dabigatran and warfarin groups [12 402 (10 721) vs. 11 910 (8359) IU, respectively]. Heparin dosing requirement to reach therapeutic ACT was lowest when time from last dose of dabigatran to septal puncture was 0 to <4 h. Conclusion Patients treated with dabigatran required a similar amount of unfractionated heparin as those treated with warfarin to achieve an ACT of >300 s during ablation. More heparin units were required when the time from the last dose of dabigatran to septal puncture increased.
The influence of additive manufacturing on the configuration of make-to-order spare parts supply chain under heterogeneous demand

Additive manufacturing (AM), alongside technological developments, has been used in the production of spare parts with positive results for spare parts supply chains. In this study, we investigate spare parts supply chains serving heterogeneous demands from multiple service locations under the mode of make-to-order. We aim to compare different configurations (i.e. centralised and distributed) of spare parts supply chains in terms of their performance (e.g. sojourn time and cost) and to further propose suggestions to better configure AM-based spare parts supply chains by effectively allocating AM machines at service locations (SLs) or regional distribution centres (RDCs). In order to realise these research objectives, the simulation approach is used as the main research method. Different from the existing perception, our results illustrate that the distributed deployment of AM machines does not always guarantee a quick response, and that centralised configuration is desirable when the demand rate is relatively high due to the pooling effect. The distributed configuration, however, can still be suitable, considering the development of AM technology. Our results also indicate the possibility of a mixed configuration of AM-based supply chains with the potential for outperforming the purely centralised/distributed configuration. The criteria to design such a mixed configuration are also offered.
Benzo(a)pyrene facilitates dermatophagoides group 1 (Der f 1)‐induced epithelial cytokine release through aryl hydrocarbon receptor in asthma

Environmental pollutants, which coexist with allergens, have been associated with the exacerbation of asthma. However, the underlying molecular mechanisms remain elusive. We sought to determine whether benzo(a)pyrene (BaP) co‐exposure with dermatophagoides group 1 allergen (Der f 1) can potentiate Der f 1‐induced asthma and its underlying mechanisms.
Inflammatory cytokines associated with cancer growth induce mitochondria and cytoskeleton alterations in cardiomyocytes

Cardiac dysfunction is often observed in patients with cancer also representing a serious problem limiting chemotherapeutic intervention and even patient survival. In view of the recently established role of the immune system in the control of cancer growth, the present work has been undertaken to investigate the effects of a panel of the most important inflammatory cytokines on the integrity and function of mitochondria, as well as of the cytoskeleton, two key elements in the functioning of cardiomyocytes. Either mitochondria features or actomyosin cytoskeleton organization of in vitro‐cultured cardiomyocytes treated with different inflammatory cytokines were analyzed. In addition, to investigate the interplay between tumor growth and cardiac function in an in vivo system, immunocompetent female mice were inoculated with cancer cells and treated with the chemotherapeutic drug doxorubicin at a dosing schedule able to suppress tumor growth without inducing cardiac alterations. Analyses carried out in cardiomyocytes treated with the inflammatory cytokines, such as tumor necrosis factor α (TNF‐α), interferon γ (IFN‐γ), interleukin 6 (IL‐6), IL‐8, and IL‐1β revealed severe phenotypic changes, for example, of contractile cytoskeletal elements, mitochondrial membrane potential, mitochondrial reactive oxygen species production and mitochondria network organization. Accordingly, in immunocompetent mice, the tumor growth was accompanied by increased levels of the inflammatory cytokines TNF‐α, IFN‐γ, IL‐6, and IL‐8, either in serum or in the heart tissue, together with a significant reduction of ventricular systolic function. The alterations of mitochondria and of microfilament system of cardiomyocytes, due to the systemic inflammation associated with cancer growth, could be responsible for remote cardiac injury and impairment of systolic function observed in vivo.
Durational Evidence That Tokyo Japanese Vowel Devoicing Is Not Gradient Reduction

A central question in the Japanese high vowel devoicing literature concerns whether vowels are devoiced through a categorical process or via gradient reduction. Examining how vowel height and consonantal voicing condition phrase-internal CV duration in a corpus of spontaneous Tokyo Japanese, it was found that CVs containing high vowels are substantially shorter before voiceless consonants, whilst non-high vowels do not exhibit comparable shortening. This quantitative difference between CV durations suggests a controlled temporal compression of the CV, consistent with views that Japanese vowel devoicing is produced through a categorical process targeting high vowels preceding voiceless consonants, and supports previous observations made of elicited productions.
Tracking forest dynamic trends in Belize: the role of protected areas, agriculture, and fire in the South Eastern Selva Maya

ABSTRACT The Selva Maya represents the largest expanse of tropical forest in Mesoamerica, encompassing parts of Belize, northern Guatemala, and south-eastern Mexico. Patterns and processes of forest loss in Belize are less comprehensively studied than other regions in the Selva Maya. Hence, this research tracks twenty years of forest loss in relation to Protected Areas (PAs) and transborder activity in the country. Results show that since 2000, Belize lost 11% of its forest cover. In that same period, 39.7% of this loss has seen forest recovery, predominantly in southern portion of the country, and within PAs. Ongoing forest loss in the north has expanded towards central and southern Belize. Forest loss in PAs account for 14.3% of overall loss nationwide, with fires and agricultural expansion playing a prominent role in the encroachment on forestland. A better understanding of forest loss in Belize reinforces distinctions between forest loss in the north and the south of the country and demonstrates the need for enhanced forest protection. This research provides new information to conservation planners to better understand the dynamics and drivers of forest loss and regrowth in the Selva Maya region.
Lower creatinine concentration values and lower inter-laboratory variation among Swedish hospital laboratories in 2014 compared to 1996: results from the Equalis external quality assessment program

Abstract Background Creatinine measurement for estimation of glomerular filtration rate (GFR) is a frequently used laboratory test. Differences in analytic creatinine methods have caused large inter-laboratory variation. International and national standardization efforts have been made in the last decade. Methods This study describes the results of the standardization efforts in Sweden by summarizing data for creatinine concentration in blood plasma in the Equalis quality assessment program during 1996–2014. Results Non-compensated Jaffe methods dominated in 1996–2001 (91 of 103 laboratories; 90%) and were then gradually replaced by either compensated Jaffe methods or enzymatic creatinine methods. In 2014 a majority of Swedish hospital laboratories (139 of 159; 87%) used enzymatic methods. The reported mean creatinine value by the Swedish laboratories was about 10 μmol/L higher than the isotope dilution mass spectrometry (IDMS) assured reference value in 2003, but consistent with the reference value from 2009 to 2014. The inter-laboratory CV was 7%–9% for creatinine values until 2007, and thereafter gradually decreased to about 4%–5% in 2014. Conclusions The introduction of enzymatic methods in Swedish laboratories has contributed to achieving a low inter-laboratory variation. Also, the reported values are lower for enzymatic methods compared to Jaffe methods, and the values obtained with enzymatic methods were consistent with IDMS certified values established at reference laboratories. Thus, many Swedish hospital laboratories reported 10 μmol/L lower, and more true, creatinine concentrations in 2012 than in 2003, which may cause bias in longitudinal studies.
Residential energy demand elasticity in Ghana: an application of the quadratic almost ideal demand systems (QUAIDS) model

Abstract The paper seeks to analyze residential energy use patterns and the price and energy expenditure responsiveness of household demand for residential energy in Ghana, using GLSS 7 data, the multivariate probit model, and the Quadratic Almost Ideal Demand System (QUAIDS) model. The study focuses on four main fuels; firewood, charcoal, and others (FCO), LPG, electricity, and kerosene. The results show that the demand for all household energy fuels in Ghana was significantly influenced by price, income, and social demographic factors. Household demand for electricity and LPG fuels are income elastic with values greater than 1, while FCO and kerosene fuels are income inelastic. The own-price elasticity also shows modern fuel (LPG and electricity) as the most responsive fuel to a price increase, even though all energy fuels are price inelastic and negative. The complementary cross-price elasticity of all fuels estimated must be carefully interpreted in the context of the cultural factors, socioeconomic factors, and the unique purposes of each fuel. After a robustness check was done in correcting for bias arising from zero energy expenditure, the study finds that the own-price elasticity for modern energy fuel (LGP and ECG) reduced slightly, even though the demand for all energy fuel remains negative and price inelastic. The study includes implications for policies geared towards reducing the price of residential energy fuels and policies to ensure clean and efficient residential energy fuels are readily accessible for consumption.
Load Flow Analysis of IEEE 14 Bus System Using ANN Technique

Load flow studies are introduced to acquire voltage, active and reactive power and load angle at every bus of power system to dissect its steady state conditions. Distinctive artificial neural network are produced for estimation of bus voltages and other obscure parameters of the system. A feed-forward back propagation network with sundry learning algorithms are created to acquire bus parameters. The proposed method is authenticated through a MATLAB simulation.
Prognostic value of lateral spread response during microvascular decompression for hemifacial spasm

Objective This study aimed to investigate the prognostic value of the lateral spread response (LSR) for predicting surgical outcomes following microvascular decompression (MVD) in patients with hemifacial spasm. Methods Seventy-three patients with hemifacial spasm underwent MVD with intraoperative LSR monitoring. Surgical outcomes were evaluated 1 week and 1 year after MVD and correlations between LSR characteristics and surgical outcomes were analyzed. Results The LSR disappeared completely in 61 patients during surgery (Group A; prior to insertion of Teflon felt pledgets in 11, after insertion of pledgets in 50), disappeared partially in nine patients (Group B), and remained unchanged in three patients (Group C). Fifty-five patients showed short-term and 61 patients showed long-term clinical cures during the follow-up period. The short-term and long-term cure rates were significantly higher in Group A than in Group C. There was no correlation between the time of complete LSR disappearance and surgical outcomes. Conclusions Disappearance of the LSR during MVD is correlated with the surgical outcomes. Intraoperative LSR monitoring is a reliable approach for predicting the prognosis of hemifacial spasm following MVD, but the time at which LSR disappears is not a prognostic indicator.
Recall intervals in children are individualized and extended

Abstract Objective: The aim of this study was to follow attendance patterns longitudinally by exploring length of intervals between routine dental examinations in children at the ages of 5 and 12 years, and study associations between length of recall intervals and caries prevalence, controlled for gender, parent’s background and parent’s education. Materials and methods: The study included 2960 children in one Norwegian county monitored from 5 to 12 years of age. Data were collected at clinical examinations, from dental records and by parental questionnaires. Length of recall intervals was dichotomized into short (shorter than 18 months) and long (18 months and longer). Data were analysed and tested using Chi-square statistics, correlation coefficient and multivariate regression. The study was ethically approved. Results: Recall intervals were individualized and varied from 4 to 30 months. The most frequent used recall intervals were 12, 18, 20 and 24 months. A majority of children at both ages were given long recall intervals. Multivariate logistic regression showed that the probability of having short interval was higher in children having caries experience than in caries-free children at both 5 years (OR 12.6 CI 9.9–16.0) and 12 years (OR 2.7 CI 2.3–3.1). At 5 years of age, length of recall intervals was associated with parents’ background (OR 1.8 CI 1.4–2.4) and parents’ education (OR 1.3 CI 1.0–1.5). Conclusions: The results showed that routine intervals were individualized and extended, indicating that more resources were spent on children with the highest need of dental care, aiming at reducing health inequalities.
C-terminal truncated HBx reduces doxorubicin cytotoxicity via ABCB1 upregulation in Huh-7 hepatocellular carcinoma cells

Hepatitis B virus (HBV) encoding the HBV x protein (HBx) is a known causative agent of hepatocellular carcinoma (HCC). Its pathogenic activities in HCC include interference with several signaling pathways associated with cell proliferation and apoptosis. Mutant C-terminal-truncated HBx isoforms are frequently found in human HCC and have been shown to enhance proliferation and invasiveness leading to HCC malignancy. We investigated the molecular mechanism of the reduced doxorubicin cytotoxicity by C-terminal truncated HBx. Cells transfected with C-terminal truncated HBx exhibited reduced cytotoxicity to doxorubicin compared to those transfected with full-length HBx. The doxorubicin resistance of cells expressing C-terminal truncated HBx correlated with upregulation of the ATP binding cassette subfamily B member 1(ABCB1) transporter, resulting in the enhanced efflux of doxorubicin. Inhibiting the activity of ABCB1 and silencing ABCB1 expression by small interfering ribonucleic acid (siRNA) increased the cytotoxicity of doxorubicin. These results indicate that elevated ABCB1 expression induced by C-terminal truncation of HBx was responsible for doxorubicin resistance in HCC. Hence, co-treatment with an ABCB1 inhibitor and an anticancer agent may be effective for the treatment of patients with liver cancer containing the C-terminal truncated HBx.
Second Language Development of Dialect Awareness in Spanish

Abstract:The objective of the current study is to investigate the development of awareness of dialectal differences in Spanish by second language learners in a formal language learning classroom setting in the United States. Sensitivity toward different regional varieties of a language forms part of socio-linguistic—and ultimately, communicative—competence (Bachman, 1990; Canale and Swain 1980; Canale 1983), a primary objective of language learning. However, the role of dialect awareness in second language learning is largely not understood. 229 American English-speaking learners of Spanish across five proficiency levels of university study completed a questionnaire that elicited knowledge of dialectal phonetic variation in Spanish. Results found that, while a variety of dialectal pronunciation features and regions were identified, learners were most aware of dialectal features of Peninsular (Spain) Spanish. However, as proficiency level increased, learners became more knowledgeable of dialectal differences in pronunciation throughout the Spanish-speaking world and reported explicit knowledge of a greater variety of dialectal structures and regions. Patterns in the development of dialect awareness in a second language are identified, and implications of dialect awareness for language learning and teaching are explored.
Microwave-Assisted Solvothermal Synthesis of Nanocrystallite-Derived Magnetite Spheres

The synthesis of magnetic particles triggers the interest of many scientists due to their relevant properties and wide range of applications in the catalysis, nanomedicine, biosensing and magnetic separation fields. A fast synthesis of iron oxide magnetic particles using an eco-friendly and facile microwave-assisted solvothermal method is presented in this study. Submicron Fe3O4 spheres were prepared using FeCl3 as an iron source, ethylene glycol as a solvent and reductor and sodium acetate as a precipitating and nucleating agent. The influence of the presence of polyethylene glycol as an additional reductor and heat absorbent was also evaluated. We reduce the synthesis time to 1 min by increasing the reaction temperature using the microwave-assisted solvothermal synthesis method under pressure or by adding PEG at lower temperatures. The obtained magnetite spheres are 200–300 nm in size and are composed of 10–30 nm sized crystallites. The synthesized particles were investigated using the XRD, TGA, pulsed-field magnetometry, Raman and FTIR methods. It was determined that adding PEG results in spheres with mixed magnetite and maghemite compositions, and the synthesis time increases the size of the crystallites. The presented results provide insights into the microwave-assisted solvothermal synthesis method and ensure a fast route to obtaining spherical magnetic particles composed of different sized nanocrystallites.
Motivation Of Fraud: Internal Control System, Organizational Justice, Compensation, And Information Asymmetry

The purpose of this research is to analyze the elements that cause an employee or a leader to be motivated so that fraud occurs. The elements in question are compensation, information asymmetry, internal control, and organizational justice. The data for the research was obtained from the collection of questionnaires from a number of 102 resource persons who were employees of BPR Primaesa Sejahtera located in North Sulawesi. For the hypothesis that is tested with multiple regression model (multiple regression model) through SPSS software. The results obtained from the research is that compensation adjustment does not have an effect on the encouragement of fraud asymmetry has a significant positive effect on encouraging organizational control and internal control has a negative effect on the occurrence of incentives. To prevent someone from being compelled to commit fraud within the organization, organizational leaders are required to apply the principles of fairness and effective continuous evaluation in internal control and monitoring of information systems by providing correct information directions in line with organizational needs.
An Adaptive High Order Direct Solution Technique for Elliptic Boundary Value Problems

This manuscript presents an adaptive high order discretization technique for elliptic boundary value problems. The technique is applied to an update version of the Hierarchical Poincare-Steklov (HPS) method. Roughly speaking, the HPS method is based local pseudospectral discretizations glued together with Poincare-Steklov operators. The new version a modified tensor product basis which is more efficient and stable than previous versions. The adaptive technique exploits the tensor product nature of the basis functions to create a criterion for determining the parts of the domain that require additional refinement. The resulting discretization achieves the user prescribed accuracy and comes with an efficient direct solver. The direct solver increases the range of applicability to time dependent problems where the cost of solving elliptic problems previously limited the use of implicit time stepping schemes.
Predictors for COVID-19 Complete Remission with HRCT Pattern Evolution: A Monocentric, Prospective Study

There are growing concerns that some COVID-19 survivors may acquire fibrosis and other irreversible lung abnormalities. The purpose of this prospective study was to assess the rate and predictors of complete resolution of COVID-19 pneumonia by pursuing a hypothetical relation between time and imaging pattern evolution using HRCT findings. A monocentric prospective cohort study with a consecutive-case enrolment design was implemented during a five-month period, having a total of 683 post-COVID patients eligible for inclusion and 635 evaluations with complete follow-up for chest HRCT. The target for post-COVID evaluations consisted of performing HRCT 90 days after a confirmed SARS-CoV-2 infection. The studied patients had an average age of 54 years, ranging between 18 and 85 years old, and an average duration from the first symptoms until HRCT was performed of 74 days. At the post-COVID follow-up, 25.8% had a complete imagistic remission. The most common appearance with HRCT was “ground glass” in 86.6% in patients with persistent COVID-19, followed by reticulations, present in 78.8%, and respectively pleural thickening in 41.2% of cases. The mean total HRCT scores were statistically significantly higher in patients older than 65 years (10.6 ± 6.0) compared to the 40–65 group (6.1 ± 6.1) and the 18–40 age group (2.7 ± 4.8) (p < 0.001). Chest HRCT is a “time window” in documenting temporal persistent radiologic features of lung injury 90 days after SARS-CoV-2 infection, determining the pathologic basis of so-called “long COVID”. The complete remission was associated with a significantly higher average follow-up period and a significantly lower average patient age. Persistent HRCT features of ground glass, reticulation, and pleural thickening are associated with a higher total CT score and older age.