Miracle-dz/UniFAR-FTUs huggingface dataset:
Effect on MicroRNA-92a in Atherosclerosis along with FlowMediated Vasodilation Study

Atherosclerosis has been regarded as an inflammatory disease. The vascular endothelium is considered as having multiple functions, regulating vascular tone, thrombosis, haematosis, permeability and cell adhesion. The emergence of microRNAs (miRNAs) as significant regulators of pathophysiological processes has indicated novel molecular insights and provided new therapeutic targets in atherosclerotic condition. Many studies have revealed that miRNA are associated with cardiovascular disease (CVD). With respect to miR-92a, miR -92a, a member of the miR-17 to miR-92 cluster, is expressed highly in endothelial cells (ECs) and regulated by shear stress. Both In vitro and vivo, miR-92a expression is highly induced in atheroprone regions compared with atheroresistant regions under disturbed flow (d-flow) condition. The clinical and experimental studies have suggested that inhibition of miR-92a can contribute to the improvement of endothelial dysfunction, inflammation, and oxidative stress in atherosclerosis. Recent reports showed that antimiR-92a as novel therapeutic options can be attributed to the endothelial cell autophagy and cardiomyocyte metabolism and that mechanistically, atherosclerotic status promote the packaging of functional miR-92a-3p into endothelial microvesicles, thereby promoting angiogenic response into recipient endothelial cells. It is strongly suggested that miR-92a-3p, having novel biological function and mechanism is a potent therapeutic target in atherosclerosis-related diseases. It is putative that flow-mediated vasodilation (FMD) study, early surrogate marker of endothelial function may in part reflect miR-92a, multifunctional biomarker
OPTIMAL TENSILE-SHEAR STRENGTH OF GALVANIZED/MILD STEEL (SPCC-SD) DISSIMILAR RESISTANCE SPOT WELDING USING TAGUCHI DOE

This paper demonstrates the optimization of resistance spot welding on different connections of galvanized steel sheets and low carbon steels. The zinc coating on galvanized steel sheets will have an effect to reduce the welding ability in the resistance welding process. The practical Taguchi experimental technics were used by implemented adequately to optimize input factors, namely squeezing time, welding current, welding time and holding time. Statistical software implemented an analysis of variance (ANOVA) and multilinear regression to investigate and evaluate the significant input factors and compare them with the experimental output factors of resistance spot welding. The 'signal to noise ratio' (S/N ratio) results shows that the welding time and the welding current are the most significant factors on the output. The delta values ​​of welding time and welding current are 3.15 and 2.25, respectively. The ANOVA results showed that welding current and welding time are the most contributing factors by 23.5% and 51.4%, respectively. Taguchi recommends an optimal squeezing time of 20 cycles, a welding current of 27 kA, a welding time of 36 cycles, and a hold/cooling time of 15 cycles. The highest output reaches a tensile shear strength of 5762.04 N on the third iteration. The present research has successfully identified significant variable inputs for resistance spot welding, namely welding current and welding time. In the future, the relevant research may use our corresponding results to improve the RSW practical procedure for other significant impacts.
Nutritional Effects of Adding Quinoa to Bread: A Systematic Review

Context: Considering the importance of bread as a staple food in many countries around the world, including Iran, Objectives: This study aimed to assess the nutritional values (i.e., protein content, fat content, carbohydrates, vitamins, minerals, and antioxidant activity) of quinoa-wheat bread compared to simple wheat bread. Methods: A search was conducted in electronic databases, including PubMed, Scopus, and Web of Science, as well as Google Scholar search engine. After screening the title and full-text of the articles, data were extracted by two independent researchers; a third researcher interfered in case of disagreement. Keywords, including “Chenopodium quinoa”, “Quinoa”, and “bread”, were obtained from the MeSh database and the manuscripts of related articles. All papers written in English language, which were published before March 2022, were selected for this review. Results: Among 159 initially extracted articles, 38 were selected by screening the titles and removing duplicates and irrelevant papers. Eleven articles were finally included in this review. Overall, the results showed significantly higher protein, fat, and fiber content in quinoa-wheat bread compared to simple wheat bread. Conclusions: Based on the results, the addition of quinoa flour could promote the health benefits of bread by increasing the protein, lipid, fiber, and micronutrient contents. It is suggested to optimize the nutritional value of the Iranian’s staple food by adding quinoa flour to wheat bread.
pH-Sensitive Poly(acrylic acid)-g-poly(L-lysine) Charge-Driven Self-Assembling Hydrogels with 3D-Printability and Self-Healing Properties

We report the rheological behavior of aqueous solutions of a graft copolymer polyampholyte, constituted of polyacrylic acid (PAA) backbone grafted by Poly(L-lysine) (PAA-b-PLL). The graft copolymer self-assembles in aqueous media, forming a three-dimensional (3D) network through polyelectrolyte complexation of the oppositely charged PAA and PLL segments. Rheological investigations showed that the hydrogel exhibits interesting properties, namely, relatively low critical gel concentration, elastic response with slow dynamics, remarkable extended critical strain to flow, shear responsiveness, injectability, 3D printability and self-healing. Due to the weak nature of the involved polyelectrolyte segments, the hydrogel properties display pH-dependency, and they are affected by the presence of salt. Especially upon varying pH, the PLL secondary structure changes from random coil to α-helix, affecting the crosslinking structural mode and, in turn, the overall network structure as reflected in the rheological properties. Thanks to the biocompatibility of the copolymer constituents and the biodegradability of PLL, the designed gelator seems to exhibit potential for bioapplications.
Effect of noise intensity on vital parameters of newborns in a tertiary care hospital

Objective: To find effect of noise intensity on heart rate, respiratory rate and oxygen saturation in late preterm and term newborns in a tertiary care hospital. Method: A controlled prospective study was carried out on 100 preterm and term newborns in the Surat Municipal Institute of Medical Education and Research during a 3 month period. Newborns were exposed to white noise of different intensities for 5 seconds and vital parameters were recorded. A statistical analysis was performed with SPSS 16.0. Results: Out of the 100 newborns, 65 were term and 35 were late preterm (34-36 weeks). Male to female ratio was 51:49. Heart rate increased significantly (p Conclusions: A 5 second white noise has a variable effect on the vital parameters of newborns; it accelerates heart rate and decreases oxygen saturation but has no effect on respiratory rate and gender. Sri Lanka Journal of Child Health , 2017; 46 : 66-69
Effects of Infertility Drug Exposure on the Risk of Borderline Ovarian Tumors: A Systematic Review and Meta-Analysis

Whether infertility drug exposure increases the risk of borderline ovarian tumors (BOTs) remains controversial. The present study was conducted with a comprehensive search for studies published from January 1990 to December 2021 in the online databases Cochrane Library, PubMed, Web of Science and EMBASE. We considered the first diagnosis of a BOT as the primary outcome. The odds ratio (OR) was calculated with corresponding 95% confidence intervals (CIs) for the risk of BOTs in patients who were treated with infertility drugs. Ten studies, a total of 2,779,511 women, qualified for inclusion in this meta-analysis. The pooled OR of 1.56 (95% CI: 1.09–2.22) revealed a significant positive association between infertility drugs and an increased risk for BOTs, but for specific drugs, only CC plus Gn had statistical significance. No publication bias was detected using the Egger and Begg tests (p > 0.05). A significant difference in BOT incidence was observed among infertile women and nulliparous women who were treated with or without infertility drugs. In conclusion, the use of infertility drugs may increase the risk of BOTs, but a dose-dependent relationship was not observed between the number of assisted reproduction technology cycles and the risk of BOTs, and infertile women who successfully became pregnant might have a reduced risk. Registration: PROSPERO, CRD42022330775.
The Evidence-Base for Psychodynamic Interventions with Children Under 5 Years of Age and Their Caregivers: A Systematic Review and Meta-Analysis

ABSTRACT Experiences in the first years of life can shape a range of outcomes throughout the lifespan. Effective early interventions have the potential to offset negative outcomes associated with early adversity. A broad range of psychodynamic interventions are available to children under five and their caregivers but there is a lack of research synthesizing the current evidence for their effectiveness. This paper presents a systematic review and meta-analysis of the evidence for the effectiveness of psychodynamic interventions for children under 5 years of age and their caregivers. Following a systematic search of 10 databases and screening for eligibility, 77 papers were included in the review. Most studies reported positive outcomes on a range of parent and infant domains. The meta-analyses of controlled studies found significant effects of psychodynamic interventions compared to control conditions on parental reflective functioning, maternal depression, infant behavior, and infant attachment. No significant differences between psychodynamic and control interventions were found for parental stress, and parent-infant interactions. Very few studies were rated as good quality and further high-quality research is needed.
Expressed sequence tag-based prediction of putative genes responsive to drought tolerance in rice (Oryza sativa) using in silico approach

In present genomic era, rapid genetic gains can be achieved by exploitation of novel genes associated with the trait of interest employing molecular breeding and genetic engineering. In the present study genes responsible for drought stress in rice 10746 expressed sequence tags (ESTs), expressed under drought stress condition were retrieved from the NCBI. The downloaded ESTs were clustered and assembled into 1120 contigs and 5559 singletones using CAP3 programme. The contigs were further subjected to identification of transcription factor, a total of 62 putative transcription factors were identified and sorted into 17 putative TF families. The contigs were subjected to BLASTX in NCBI to identify unique sequence which were further aligned to Oryza sativa Indica Group (ASM465v1) in gramene database using BLAT to retrieve the upstream and downstream sequences for putative gene identification. The retrieved sequences were analysed for transcription start site, PolyA tails and coding sequences which are essential features of gene using online tool fsgene. The present study found that, 46 contigs out of 1120 contigs has key gene structure and was considered as putative novel genes which may contribute to the drought tolerance in indica rice. These genes may be useful in development of drought tolerant varieties through smart breeding
Intra-Familial Spread of HBV among HbsAg Positive Parents and their Children in a Defined Rural Community of District Peshawar, Pakistan

Background: HBV horizontal and vertical transmission rate vary among population in different social communities. To know the leading cause of HBV transmission among a community would ease the planning and strategies to minimize the spread. The objectives were to determine the frequency of different mode of intra-familial spread of Hepatitis B among the infected index identified families of rural community of Peshawar. Methods: This was 18 months descriptive cross-sectional study conducted among married couples of a defined rural community of district Peshawar. After taking informed consent from 797 couples of rural community, 3 to 5 ml blood sample was collected from each respondents for HbsAg screening along with the required data collected using predesigned questionnaire using convenient sampling techniques. HbsAg positive cases were considered as HBV index. Index case of both Hbs Ag positive parents were decided based on past history, previous exposure, past diagnosis and treatment record. The spouses and children of index cases were screened for serological determinants like HbsAg, HbeAg and ALT. Data was gathered and analyzed using SPSS version 16.0. Results: A total of 797 couples (1593 parents) were selected with proportion of household from ten different blocks of village Budhni. The prevalence of HBV infection among parents was found 1.5%. Nineteen HBV index families were detected among 797 parents screened for HbsAg. Spouse transmission rate of HBV were found 26.3% on average Transmission of HBV infection rate from index mother to children was 11.8%. About 10.5% index females were HbeAg positive. Conclusion: HBV transmission was high among the spouses followed by vertical transmission in a rural community of district Peshawar.
An operational model for capturing grape ripening dynamics to support harvest decisions

Grape ripening is a critical phenological phase during which many metabolites that impact wine quality accumulate in the berries. Major changes in berry composition include a rapid increase in sugar and a decrease in malic acid content and concentration. Its duration is highly variable depending on grapevine variety, climatic parameters, soil type and management practices. Together with the timing of mid-veraison, this duration determines when grapes can be harvested.Viticulturists and winemakers monitor the sugar-to-total acidity ratio (S/TA) during grape ripening and start harvesting grapes when this ratio reaches the optimum value for the desired wine style. The S/TA ratio evolves linearly as a function of thermal summation during the first four weeks following the onset of ripening. The linearity of the evolution of the S/TA ratio as a function of thermal time during the first four weeks following mid-veraison is applied in this study on two large data sets encompassing (1) 53 varieties studied during 10 years with two to four replicates for each combination of year and cultivar and (2) two varieties, cultivated on three soil types over 13 years. Grape ripening speed is highly variable. The effects of the year impact ripening speed more than the effects of the soil or the variety, although all three effects are highly significant. Grape ripening speed decreases with berry weight and also varies with vine water status. By using this approach, viticulturists and winemakers can assess four weeks after mid-veraison, for each individual vineyard parcel, at what speed grape ripening progresses. Combined with precise mid-veraison scoring, expertise from previous vintages and complementary approaches like sensory assessment of berries, it allows harvest date estimates to be fine-tuned. The results of this study can also be used to identify slow ripening varies, which are better performing in warm climates and, thus, better adapted to climate change.
FACTORS DETERMINING THE USE OF MOBILE BANKING IN INDONESIA

This study was aimed at determining the factors that could influence a person’s decision to use mobile banking. In this study, perceived usefulness, perceived ease of use, and perceived credibility were considered exogenous variables, and social factors as mediators. This research used quantitative methods. The population in this study were Indonesian Sharia Bank customers who used BSI mobile banking services in the Jakarta, Bogor, Depok, Tangerang and Bekasi areas. A sample of 200 people was obtained using the purposive sampling method. The analysis technique used was the inner model, outer model, and hypothesis testing using SmartPLS 3.2. 9. The results obtained in this study showed that perceived usefulness had a significant effect on decisions to use mobile banking, perceived ease of use had no significant effect, and perceived credibility had a significant effect. In addition, this study has also shown that social factors did not succeed in mediating other variables in the decision to use mobile banking.
Tighter Robust Upper Bounds for Options via No-Regret Learning

Classic option pricing models, such as the Black-Scholes formula, often depend on some rigid assumptions on the dynamics of the underlying asset prices. These assumptions are inevitably violated in practice and thus induce the model risk. To mitigate this, robust option pricing that only requires the no-arbitrage principle has attracted a great deal of attention among researchers. In this paper, we give new robust upper bounds for option prices based on a novel η-momentum trading strategy. Our bounds for European options are tighter for most common moneyness, volatility, and expiration date setups than those presented in the existing literature. Our bounds for average strike Asian options are the first closed-form robust upper bounds for those options. Numerical simulations demonstrate that our bounds significantly outperform the benchmarks for both European and Asian options.
Magnetically Modulated Heat Transport in a Global Simulation of Solar Magneto-convection

We present results from a global MHD simulation of solar convection in which the heat transported by convective flows varies in-phase with the total magnetic energy. The purely random initial magnetic field specified in this experiment develops into a well-organized large-scale antisymmetric component undergoing hemispherically synchronized polarity reversals on a 40 year period. A key feature of the simulation is the use of a Newtonian cooling term in the entropy equation to maintain a convectively unstable stratification and drive convection, as opposed to the specification of heating and cooling terms at the bottom and top boundaries. When taken together, the solar-like magnetic cycle and the convective heat flux signature suggest that a cyclic modulation of the large-scale heat-carrying convective flows could be operating inside the real Sun. We carry out an analysis of the entropy and momentum equations to uncover the physical mechanism responsible for the enhanced heat transport. The analysis suggests that the modulation is caused by a magnetic tension imbalance inside upflows and downflows, which perturbs their respective contributions to heat transport in such a way as to enhance the total convective heat flux at cycle maximum. Potential consequences of the heat transport modulation for solar irradiance variability are briefly discussed.
On the Relationship between a Student Association’s Endeavors to Foster a Social–Academic Climate on Campus, Students’ Self-Efficacy, and Academic Motivation

The current study is a case study examining a student association’s endeavors to foster a social–academic climate on campus, grant students a sense of self-efficacy, and even contribute to students’ motivation. The research literature lacks empirical knowledge on the activity of student associations and their contribution to institutions of higher education and their students. Moreover, academic institutions see student associations at times as a burden, a type of labor union to be placated by the faculty and the academic institution. The research sample consisted of 122 students from a university in Israel (38 men and 84 women; mean age 25). Several questionnaires were administered to the respondents: a questionnaire on the social–academic climate on the academic campus, a questionnaire on students’ academic motivation, a questionnaire on students’ self-efficacy, and a sociodemographic questionnaire. From the research findings, it is evident that the activities of the student associations on the academic campus play a meaningful role in fostering students’ academic motivation and self-efficacy. The research findings indicate that the scope of student association activities is positively related to the students’ academic motivation and self-efficacy. Moreover, students living in student dorms were found to evaluate the activities of the student association as higher than did students who were not living in student dorms. These findings constitute a preliminary foundation for future studies on the importance of student associations in academic institutions and their contribution to the students. Furthermore, these findings highlight the need to boost and increase student associations’ activities to provide students with adapted and efficient solutions to their challenges. The student association can be transformed from a burden to an asset for the academic institution.
Advances in nutritional supplementation for sarcopenia management

Sarcopenia is a syndrome characterized by a decline in muscular mass, strength, and function with advancing age. The risk of falls, fragility, hospitalization, and death is considerably increased in the senior population due to sarcopenia. Although there is no conclusive evidence for drug treatment, resistance training has been unanimously recognized as a first-line treatment for managing sarcopenia, and numerous studies have also pointed to the combination of nutritional supplementation and resistance training as a more effective intervention to improve quality of life for people with sarcopenia. People with both malnutrition and sarcopenia have a higher mortality rate, so identifying people at risk of malnutrition and intervening early is extremely important to avoid sarcopenia and its associated problems. This article provides important information for dietary interventions in sarcopenia by summarizing the discoveries and developments of nutritional supplements such as protein, leucine, β-hydroxy-β-methylbutyric acid, vitamin D, vitamin C, vitamin E, omega-3 fatty acids, creatine, inorganic nitrate, probiotics, minerals, collagen peptides, and polyphenols in the management of sarcopenia.