Miracle-dz/UniFAR-FTUs huggingface dataset:
A Phase 1b clinical trial of LDE225 (Sonidegib) in combination with fluorouracil, leucovorin, oxaliplatin, and irinotecan (FOLFIRINOX) in previously untreated locally advanced or metastatic pancreatic adenocarcinoma

Harvard Medical School, Boston, MA, USA; Massachusetts General Hospital Cancer Center, Boston, MA, USA; Yale Cancer Center, New Haven, CT, USA; Dana Farber Cancer Institute, Boston, MA, USA; Dartmouth-Hitchcock Norris Cotton Cancer Center, One Medical Center Drive, Lebanon, NH, USA Contributions: (I) Conception and design: JW Clark, EL Kwak, TS Hong; (II) Administrative support: None; (III) Provision of study materials or patients: JW Clark, JN Allen, LS Blaszkowsky, JE Murphy, C Fuchs, BM Wolpin, RJ Mayer, JE Farris, JA Chan, K Ng, NJ McCleary, TA Abrams, DP Ryan, EL Kwak; (IV) Collection and assembly of data: JW Clark, N Horick, EL Kwak, TS Hong; (V) Data analysis and interpretation: JW Clark, N Horick, EL Kwak, TS Hong; (VI) Manuscript writing: All authors; (VII) Final approval of manuscript: All authors. These authors contributed equally to this work. Correspondence to: Jeffrey W. Clark, MD. Massachusetts General Hospital Cancer Center, 55 Fruit Street, 223 Bartlett Hall, Boston, MA 02114, USA. Email: clark.jeffrey@mgh.harvard. edu.
Assessing the effectiveness of ketorolac in pain management of traumatic injuries in prehospital emergency care services

Objective: Pain is usually one of the most common symptoms among all traumatic injuries. One of the drugs that has recently entered the Iranian prehospital emergency system is ketorolac. Ketorolac is a non-steroidal anti-inflammatory drug (NSAID) that inhibits prostaglandin synthesis by inhibiting cyclooxygenase activity and reduces pain and inflammation. It can be considered as the strongest analgesic drug in this category. The aim of this study was to evaluate the effectiveness of ketorolac in pain management of traumatic injuries in a prehospital setting. Methods: This descriptive cross-sectional study was undertaken to evaluate the effectiveness of a treatment method in the pain management of traumatic injuries in the prehospital environment of Lorestan province in Iran. We included 134 injured patients from road emergency bases of Lorestan province. In order to control the pain of these injured patients, 30 mg of ketorolac was injected slowly intravenously in one minute. Pain was measured in the time interval of zero minutes (before injection), 15 minutes, 30 minutes, and 45 minutes by visual acuity scale (VAS). The analysis of the obtained data was performed by SPSS software version 23. Results: The mean age of participants was 37.42±23.6. There were 47 female injuries (35.1%) and 87 male injuries (64.9%). In terms of pain intensity, 49 patients (36.6%) had moderate pain (VAS=4-6) and 85 patients (63.4%) had severe pain (VAS=7-10). The average of pain relief in the injured group with severe and moderate pain 15 minutes after the injection was 0.471 and 0.878 (P=0.001), respectively. In addition, the mean of pain relief in the injured group with severe and moderate pain 30 minutes after the injection was 1.124 and 1.796, respectively (P=0.001). Pain reduction in the group of severely injured patients with moderate pain in the first 30 minutes was statistically significant. Conclusion: Findings revealed that ketorolac is a suitable drug in pain management for trauma patients with moderate and severe pain in trauma patients. On the other hand, due to the peak effect (more than 30 minutes), it is not an effective drug for trauma patients with severe pain in a short period transferred to the prehospital environment.
An Analysis of Youth Deradicalization Programs in Northeast Nigeria: A Study on Boko Haram

Using qualitative secondary analysis, the research examine the effects of Operation Safe Corridor (OSC), a home-grown prison-based deradicalization program targeted at low-risk Boko Haram combatants, and Yellow Ribbon Initiative, an education-based recivilization program designed for young adult women associated with Boko Haram. Together with pioneer countries like Saudi Arabia and Indonesia, the structural design and implementation of OSC remain shrouded in utmost secrecy. Even though it claims to have rehabilitated over 2,000 ex-Boko Haram combatants, there is no medium to independently ascertain these claims. Relatedly, the Yellow Ribbon Initiative also claimed to have successfully reintegrated thousands of women, with little to no means to validate their claims independently. Premised on the need to implement context-specific, inclusive and robust counterinsurgency programs, the research takes issues with both programs. Furthermore, the lack of accountability and transparency in the operations of both programs put to question their credibility and objectiveness. Alternatively, the research suggests the need for a paradigm shift from deradicalization to counter-radicalization, as this will put the government on the offensive side against radicalization. If targeted at volatile communities, counter-radicalization could be designed to address underlying causalities such as unequal education opportunities and poor social infrastructure,
Relationship Of Knowledge, Attitude With SADARI Behavior As An Early Detection Of Breast Cancer In Students Of The Faculty Of Public Health, Teuku Umar University Meulaboh

Breast cancer cases are quite high in Indonesia, namely 42 per 100,000 population and are the main cause of death for women in Indonesia. The purpose of this study was to analyze the relationship between knowledge and attitudes with awareness behavior (self-breast examination) in students of the Faculty of Public Health, Teuku Umar University, Meulaboh. The research design was cross sectional with a quantitative approach with univariate and bivariate analysis. The population of this study were female students at the Faculty of Public Health, Teuku Umar University Meulaboh, West Aceh Regency with a sample of 143 female students. The results of the study concluded that most of the respondents had never realized it as many as 84 people (58.7%). The factors of knowledge and attitudes about awareness are related to the behavior of being aware
Innovation competition in horizontal mergers: choosing the framework for Competition Policy assessment

This article discusses the assessment of horizontal mergers and harm to innovation when there is innovation competition. The goal is to build a scheme for the proper choice of the framework of analysis, presenting, for each situation: mechanisms to identify innovation competition, to undertake market definition, to assess the competitive significance of firms, identification of the appropriate theories of harm and evidence. We review the literature on Competition Policy and on Economics of Innovation and take examples from the US and European case law. We also briefly discuss the strategic management literature to provide insights for the assessment. Considering post-merger reductions on innovation incentives as harm to innovation, we find differences of traditional merger procedure adequacy and challenges to build evidence, considering three faces of innovation, including possible combinations of these faces within a same merger case: (i) incremental innovation efforts in the product market, (ii) ongoing efforts for developing new products and (iii) future innovation efforts. When the traditional merger procedure is inadequate, we argue in favor of using a capabilities-based assessment, changing the step-by-step procedure. keywords: Competition Policy, Mergers, Innovation, Capabilities
Implementation of Sustainable Financing in Banking Industry

Abstract This study wants to explore how to implement sustainable finance in the financial services industry, given the objectives of sustainable finance. This is will essential for realizing sustainable economic growth while still paying attention to environmental sustainability and the financial services industry, including industries that already have a concept to participate in sustainable development. This study is expected to contribute to developing concepts and theories related to financial and environmental performance. This research method is a literature study to systematically identify and analyze document documents that contain or relate to problems in the research carried out. The final stage is to find the main concepts based on data to be visualized or presented in the form of data analysis results. Results Until now, few studies in Indonesia have examined sustainable finance implementation in the Financial Services Industry Sector. Many financial industries have not correctly implemented the concept of sustainable development, which has been transformed into the financial services industry sector. Keywords: Implementation, Sustainability, Financing, Banking
Dynamics of plankton in substrate based fish & prawn culture

A study was conducted to evaluate the effect of periphyton substrate on plankton dynamics. Sugarcane bagasse is used as a substrate for periphyton growth. Three experimental treatments were included; T0 (Control), T1 (Substrate + feed) and T2 (substrate only). Indigenous fishes like Labeo fimbriatus (Bloch,1795), Barbodes carnaticus (Jerdon,1849) and freshwater prawn, Macrobrachium rosenbergii were stocked in tanks in 3:3:4 ratio at 10000/ha, for a period of 180 days. Bagasse substrate influenced the water quality parameters viz., pH (6.73 – 8.17), dissolved oxygen (6.70 – 8.50). Low concentration of Ammonia (0.068 – 0.140 mg/l) and Nitrite (0.046 – 0.082) was observed in substrate based ponds. A decreasing trend was observed in periphyton DM, AFDM and ash content value in both the treatment near the termination of experiment, which indicates effective grazing on periphyton by cultured fish species. Also, pigment concentration was also found high in substrate ponds. The result demonstrate that sugarcane bagasse can effectively use as a substrate for enhancing the population of plankton.
An empirical model for understanding the threat responses at the time of COVID-19

Background: The COVID-19 pandemic represents a global challenge which may have pervasive effects in several areas of community and individual life. Consequently, the virus could generate fear and anxiety that must be managed in a new and unknown situation, such as that of lockdown, with potential consequences for mental health outcomes. Therefore, with the theoretical guide of the Polyvagal perspective, this research aimed to analyse the mediation of social support, passive aggression, avoidance and dissociation in the relationship between fear and anxiety during the COVID-19 pandemic. Methods: During the national COVID-19 lockdown phase, a sample of 992 Italian participants with a mean age of 35.07 years ( SD = 12.11) completed the Ten Penn State Worry Questionnaire, State-Trait Anxiety Inventory – Form X3, Coping Orientation to Problems Experienced and Forty Item Defense Style Questionnaire, after providing written informed consent. Results: Results showed that fear affected anxiety, both directly and indirectly, highlighting a serial multiple mediation model with two parallel chain of mediators. Social support coping strategy negatively influenced fear and passive aggression, which instead were positively associated. Furthermore, in the second chain, avoidance directly induced fear in the presence of anxiety, opposite of dissociation defense mechanism. Conclusions: Such findings highlighted some possible answers that could be implemented as a consequence of the fear perception during the COVID-19 lockdown, according to the framework of the Polyvagal Theory. These data could provide an important contribution in shedding light on mechanisms put in place during the pandemic, promoting valuable information for a more effective clinical practice.
In vivo Genotoxicity Assessment of Matrine and the Water Extract of Sophorae Radix Using a Comet Assay

The genotoxic potentials of the water extract of Sophorae Radix (WSR) and matrine as a major compound were investigated in murine hepatocytes and blood cells using single-cell gel electrophoresis. According to the test guidelines of OECD TG 489, an in vivo alkaline Comet assay was performed using male mice. The treatment doses of the WSR were 1,000 and 2,000 mg/kg body weight to include the limiting dose. The three test doses for matrine were 50, 100, and 200 mg/kg, and the maximum dose was estimated from a dose range-finding test. The negative control and test articles were administered three times by oral gavage, and the positive control (ethyl methanesulfonate, EMS) was administered twice. Within 3-4 h after the last treatment, the liver tissue and blood were collected, and single-cell electrophoresis was performed under alkaline conditions. The in vivo Comet assay showed no changes in body weights during the treatments with the test articles. The WSR and matrine did not induce significant DNA damage in the liver and blood cells of mice compared to the vehicle treatment. In conclusion, matrine and the WSR may not have genotoxic potential.
A Numerical Method For Solving Fractional Optimal Control Problems Using The Operational Matrix Of Mott Polynomials

‎This paper presents a numerical method for solving a class of fractional optimal control problems (FOCPs) based on numerical polynomial approximation‎. ‎The fractional derivative in the dynamic system is described in the Caputo sense‎. ‎We used the approach in order to approximate the state and control functions by the Mott polynomials (M-polynomials)‎. ‎We introduced the operational matrix of fractional Riemann-Liouville integration and apply it to approximate the fractional derivative of the basis‎. ‎We investigated the convergence of the new method and some examples are included to demonstrate the validity and applicability of the proposed method‎.
Analyzing German winery adoption of Web 2.0 and social media

ABSTRACT The purpose of this research study was to analyze the adoption of Web 2.0 and social media by German wineries, as well as to determine the impact of winery size on the use of social media and response time to consumer emails. The methodology involved a content analysis of 208 German winery websites and a statistical analysis of how German wineries respond to customer email requests. Results show a relatively low adoption of Web 2.0 (27%) by German wineries with larger wineries adopting more components than smaller wineries, though smaller wineries responded more quickly to customer email requests for wine information. Implications suggest that there is more opportunity for German wineries to integrate social media in their wine marketing strategy.
Seasonal Changes and the Interaction Between the Horse Chestnut Leaf Miner Cameraria ohridella and the Horse Chestnut Leaf Blotch Guignardia aesculi

The horse chestnut leaf miner Cameraria ohridella (Lepidoptera: Gracillariidae) is an invasive pest of horse chestnut and has spread through Europe since 1985. The horse chestnut leaf blotch Guignardia aesculi (Botryosphaeriales: Botryosphaeriaceae) is a fungal disease that also seriously damages horse chestnut trees in Europe. The interaction between the leaf miner and the fungus has not yet been sufficiently described. Therefore, the aim of the present study was to assess leaf damage inflicted to horse chestnut by both C. ohridella and G. aesculi during the vegetation season and to model their interaction. The damage to leaf area was measured monthly from May to September 2013 in České Budějovice, the Czech Republic. A simple phenomenological model describing the expected dynamics of the two species was developed. The study revealed a significant effect of sampling site and sampling period on the damage caused by both the pest and the fungus. The mathematical model indicates that infestation by C. ohridella is more affected by G. aesculi than vice versa. The possible mechanisms affecting the relationship between G. aesculi and C. ohridella are discussed.
Abnormal ST segment in electrocardiograph predicts poor outcome in patients with acute subarachnoid hemorrhage

Background and purpose: There are high occurrences of abnormal electrocardio-graphic (ECG) in patients with acute subarachnoid hemorrhage (SAH). Thus, we want to determine whether any specific characteristics in ECG are associated with poor clinical outcomes in patients with SAH inhospital. Methods: A total of 145 patient who selected from 270 cases with non-traumatic SAH was included in this study. A standard surface ECG was assessed for all patients within 72 hours of SAH onset. All patients were stratified into Good or Poor outcome groups according to the in-hospital mortality or neurological worsening (World Federation of Neurological Surgeons, WFNS class) when they discharge from our hospital. Results: These patients in Poor outcome (n = 29) had significantly high heart rate (93.52± 22.23 bpm vs 78.42 ± 18 bpm, P < 0.01), prolonged QTc (458.17 ± 44.88 ms vs 436.89 ± 43.46 ms, P = 0.027) and corrected Tpeak–Tend interval (cTp-e, 106.19 ± 22.22 ms vs 93.14 ± 21.04 ms, P = 0.007) and high occurrence of ECG abnormalities including ST segment (90% vs 44%, P < 0.01) and left ventricular high voltage (28%vs 10%, P = 0.03). Multivariable logistic regression identified independent variables indicating poor outcome in-hospital including abnormal ST (OR = 2.507, 95% CI, 1.051-5.941, P = 0.037) and WFNS class (OR = 2.280, 95% CI, 1.605-3.240, P < 0.001). Conclusions: Abnormal ST segment of ECG is an independent indicator for poor inhospital outcomes regardless the severity of patients with SAH and warrant to further study their mechanism in the future.
Storage‐discharge characteristics of an active rock glacier catchment in the Innere Ölgrube, Austrian Alps

The active rock glacier “Innere Ölgrube” and its catchment area (Ötztal Alps, Austria) are assessed using various hydro(geo)logical tools to provide a thorough catchment characterization and to quantify temporal variations in recharge and discharge components. During the period from June 2014 to July 2018, an average contribution derived from snowmelt, ice melt and rainfall of 35.8%, 27.6% and 36.6%, respectively, is modelled for the catchment using a rainfall‐runoff model. Discharge components of the rock glacier springs are distinguished using isotopic data as well as other natural and artificial tracer data, when considering the potential sources rainfall, snowmelt, ice melt and longer stored groundwater. Seasonal as well as diurnal variations in runoff are quantified and the importance of shallow groundwater within this rock glacier‐influenced catchment is emphasized. Water derived from ice melt is suggested to be provided mainly by melting of two small cirque glaciers within the catchment and subordinately by melting of permafrost ice of the rock glacier. The active rock glacier is characterized by a layered internal structure with an unfrozen base layer responsible for groundwater storage and retarded runoff, a main permafrost body contributing little to the discharge (at the moment) by permafrost thaw and an active layer responsible for fast lateral flow on top of the permafrost body. Snowmelt contributes at least 1/3rd of the annual recharge. During droughts, meltwater derived from two cirque glaciers provides runoff with diurnal runoff variations; however, this discharge pattern will change as these cirque glaciers will ultimately disappear in the future. The storage‐discharge characteristics of the investigated active rock glacier catchment are an example of a shallow groundwater aquifer in alpine catchments that ought to be considered when analysing (future) river runoff characteristics in alpine catchments as these provide retarded runoff during periods with little or no recharge.
Some morphological aspects of myocardial bridges

Background: Myocardial bridges are variants of the intramyocardial position of the coronary arteries. In the specialty literature, hot topics in cardiovascular field are myocardial infarction and non-obstructive coronary artery disease with frequent connection with myocardial bridges. Material and methods: The morphological study was based on the analysis of 200 human hearts and fragments of coronary arteries. The retrospective study was focused on the analysis of 6168 coronary angiography reports, to identify patients with myocardial bridges, their preferred location, the degree of systolic stenosis, the association between myocardial bridges and proximal to bridge and under the bridge coronary atherosclerosis. Results: The complete myocardial bridges were described in 62% of the analyzed hearts and only in 5.3% of the total number of studied coronarographies. In the majority of cases, the complete myocardial bridges covered the anterior interventricular branch. The degree of subpontine arterial systolic stenosis varied within 10-95%. The comparative study did not determine any correlations between the degree of subpontine vascular compression and the degree of the left ventricular myocardial hypertrophy. In 32% of cases were described proximal to bridge atherosclerotic plaques and only in one case (0.5%) – distal to bridge atherosclerotic plaques, located immediately under the bridge. Conclusions: The research findings underline the differences in anatomical and angiographic incidence of myocardial bridges, and the inability of all bridges to reduce the lumen of under bridged artery. Current study emphasizes attention to the topography of bridges, the correlation with ventricular hypertrophy and coronary atherosclerosis.
Repeated Measure Analysis for the CD4+ Cell Counts of HIV-Positive Patients Initiated to ART: A Case Study at Ambo Hospital

Introduction: HIV is a virus that causes Acquired Immunodeficiency Syndrome (AIDS) by reducing a person's ability to fight the infection. It attacks an immune cell called the CD4 cell which is responsible for the body's immune response to infectious agents. Now a days anti retro viral therapy treatment is avail to elongate the life of patients. The treatment is given for patients to increase the CD4 counts of patients to keep the ability of body preventing the disease. Objectives: This study was aimed to identify the potential associated risk factors with CD4 counts of patients under ART treatment at public hospital in Ethiopia. The other was to fit linear mixed model by handling missing value of the data during follow up time. Method: To see the structure of the data, exploratory data analysis was conducted. Of the familiar variance structures, unstructured variance covariance is selected to be best and to fit the data under study, step-by-step procedure was passed to obtain best model. Results: The descriptive statistics directed that the progressive change in CD4 counts of females seems better than that of males. On the other hand, the output of the fitted model indicated that covariates significant with 5% level of significance is that baseline CD4, time, weight and interaction of Sex, baseline CD4 with time. Allowing the significance level to increase to 25% increases most covariates to be significant that help patients in a better awareness. Conclusion: With this result, full linear mixed with random intercept and slop is found to best model. There was high variability within patients over time and between patients and the interaction of time with covariates was also significant. Generally, the data was fitted by handling the missing value using multiple imputation technique.