Miracle-dz/UniFAR-FTUs huggingface dataset:
Evaluation of cardiovascular autonomic dysfunction according to heart rate turbulence and variability in patients with relapsing remitting multiple sclerosis

Background/aim Multiple sclerosis (MS) is an autoimmune disease characterized by neurodegeneration or demyelination; the relapsing–remitting phase of MS is characterized by acute exacerbation of disease activity. The most commonly used noninvasive approach to assess autonomic function is the determination of heart rate turbulence (HRT) and heart rate variability (HRV). The aim of this study was to evaluate the presence of cardiovascular autonomic dysfunction using HRT and HRV parameters determined via 24-h Holter ECG monitoring in patients with relapsing–remitting MS without known heart disease. Materials and methods The study included 26 patients diagnosed with relapsing–remitting MS and 22 age- and sex-matched healthy controls. HRT and HRV parameters were analyzed via 24-h Holter ECG monitoring. Magnetic resonance imaging findings were reevaluated to identify any demyelinating lesions in the brain stem. Results The HRV parameters of SDNNI (mean of the standard deviations of all normal sinus RR intervals in all 5-min segments), rMSSD (root–mean–square successive difference), and sNN50 (percentage of successive normal sinus RR intervals >50 ms) were significantly lower in the MS group than in the control group (P < 0.05). Conclusion This study revealed that the patients with MS had reduced HRV; this was demonstrated by dysfunction with regard to parasympathetic and sympathetic parameters in HRV analysis.
Group B streptococcus detection in China: comparison of different screening methods and different sampling sites

Objectives: To evaluate the use of real-time polymerase chain reaction (RT-PCR) and bacterial culture methods to detect group B streptococcus (GBS) in Chinese pregnant women in the third trimester; to separately assess the prevalence of rectal and vaginal GBS colonization ; and to determine the antimicrobial susceptibility pattern of the isolates. Methodology: Samples were collected from 505 women at 35 and 37 weeks gestation at the Peking Union Medical College Hospital. Bacterial culture and RT-PCR were performed. Antimicrobial susceptibility to commonly used antibiotics was also analyzed. Results: The overall GBS colonization rate was 7.5%. The colonization rate, sensitivity, and negative predictive value of the bacterial culture method were 2.8%, 36.8%, and 95.1%, respectively, and these values were 7.3%, 97.4%, and 99.8%, respectively, for PCR (p<0.001). The GBS colonization rate of the rectum (6.7%) was higher than that of the vagina (2.8%) (p=0.005). Antimicrobial susceptibility testing showed that 100% were sensitive to penicillin, cephalosporin and vancomycin. Conclusions: RT-PCR was found to be a rapid and sensitive test for the detection of GBS colonization in Chinese pregnant women. Rectal swabbing was also important for detecting GBS colonization. β-lactams are the first-line antibiotics used for the treatment of GBS. J Microbiol Infect Dis 2016;6(4): 179-183 Group B streptococcus, Real-time polymerase chain reaction, Sampling sites,
The genetic association between LMP2 and LMP7 polymorphisms and susceptibility of insulin dependent diabetes mellitus

Abstract Background: Insulin dependent diabetes mellitus (IDDM) is a kind of heterogeneous disease caused by the interaction of polygene inheritance and environmental factors. The LMP2 and LMP7 are 2 loci in LMP gene, and although genetic association between LMP2 and LMP7 polymorphisms were reported, the results are inconclusive. The aim of this study was to investigate the association between LMP2 and LMP7 polymorphisms and IDDM risk. Methods: An exhaustive search was performed out through the electronic databases including PubMed, Embase, and Chinese National Knowledge Infrastructure (CNKI). The pooled odds ratio (OR) and 95% confidence interval (CI) were used to assess the strength association between LMP2 CfoI and LMP7 G37360T polymorphisms and IDDM risk. Results: A total of 7 studies with 707 cases and 821 controls were included in the present study. The results indicated that the dominant model of LMP2 CfoI was significantly associated with IDDM in Asian population (OR = 1.96, 95% CI: 1.24–3.10, P = .004). In addition, the allelic and dominant models of LMP7 G37360T were associated with IDDM in Caucasian population (allelic model: OR = 0.69, 95% CI: 0.56–0.85, P = .0005; dominant model: OR = 0.67, 95% CI: 0.50–0.89, P = .007). Conclusions: The dominant model of LMP2 CfoI might be a risk factor for IDDM in Asian population. Whereas, the allelic and dominant models of LMP7 G37360T might be protective factors for IDDM in Caucasian population.
Effect of Combined Clinical Practice Guideline and Electronic Order Set Implementation on Febrile Infant Evaluation and Management

Supplemental digital content is available in the text. Objective Management of febrile infants 60 days and younger for suspected serious infection varies widely. Clinical practice guidelines (CPGs) are intended to improve clinician adherence to evidence-based practices. In 2011, a CPG for managing febrile infants was implemented in an urban children's hospital with simultaneous release of an electronic order set and algorithm to guide clinician decisions for managing infants for suspected serious bacterial infection. The objective of the present study was to determine the association of CPG implementation with order set use, clinical practices, and clinical outcomes. Methods Records of febrile infants 60 days and younger from February 1, 2009, to January 31, 2013, were retrospectively reviewed. Clinical documentation, order set use, clinical management practices, and outcomes were compared pre-CPG and post-CPG release. Results In total, 1037 infants pre-CPG and 930 infants post-CPG implementation were identified. After CPG release, more infants 29 to 60 days old underwent lumbar puncture (56% vs 62%, P = 0.02). Overall antibiotic use and duration of antibiotic use decreased for infants 29 to 60 days (57% vs 51%, P = 0.02). Blood culture and urine culture obtainment remained unchanged for older infants. Diagnosed infections, hospital readmissions, and length of stay were unchanged. Electronic order sets were used in 80% of patient encounters. Conclusions Antibiotic use and lumbar puncture performance modestly changed in accordance with CPG recommendations provided in the electronic order set and algorithm, suggesting that the presence of embedded prompts may affect clinician decision-making. Our results highlight the potential usefulness of these decision aids to improve adherence to CPG recommendations.
Potentiation of the Antidepressant Effects of Fluoxetine by Administration of Aspirin in a Mouse Model

Background: Previous studies have indicated that major depressive disorder and anxiety disorders are associated with inflammatory progressions. It has also been shown that administrations of anti-inflammatory drugs improve the patient’s psychiatric condition. These facts suggest that NSAIDs may be used as an adjunctive therapy in the management of depression. Herein, we investigated whether a combination of suboptimal dose of the selective serotonin reuptake inhibitor, fluoxetine, with aspirin improves the anti depressive effects of fluoxetine. Methods: Both mouse forced swim and tail-suspended mice, as models of animal depression, displayed respectively, inactive floating position, decreased active swimming and immobility behavior. In these models, mice were treated with single optimal (20mg/kg, ip) or suboptimal (5mg/kg, ip) doses of fluoxetine 30min prior to running experiment. Results: In contrast to fluoxetine treatment using 20mg/kg, a suboptimal dose induced no significant changes in the immobility duration time, active swimming and climbing trials. Interestingly, co-administration of 400mg/kg of aspirin significantly increased the reduction in immobility duration time in both models. This effect coincided with a significant increase in active swimming. In a subsequent experiment, the anti-immobility effect of this combined treatment was not associated with increase mouse general locomotor activity. Conclusion: These findings clearly demonstrate that aspirin potentiates the beneficial effects of fluoxetine and that psychostimulant effect does not contribute to the antidepressant value in this mouse model of depression.
Implications for the Pathogenesis of Atherosclerosis

Introduction Atherosclerosis The term, atherosclerosis, as it was originally coined by Thoma in 1886, was devised to describe a degenerative process involving the progressive hardening of the blood vessel wall. Today we have advanced to the understanding that the ultimate atherosclerotic lesion is a complex and heterogeneous arrangement of rapidly proliferating and migrating cells that produce and support an active connective tissue matrix. Two major forms of atherosclerotic lesions have been described: the fatty streak and the fibrous plaque. Classic fatty streaks are raised, narrow, yellowed lesions that extend in the direction of blood flow. They are nonobstructive and are likely, but yet unproven, precursors of more advanced lesions. The streaks are characterized by subendothelial collections of foam cells, smooth muscle cells (SMC), T-lymphocytes, and an extracellular matrix of lipid, collagen, elastin, and proteoglycan. -Monoclonal antibody studies have shown that foam cells are primarily monocyte-derived macrophages and occasionally SMC that have imbibed cholesterol and cholesterol esters.
Use of probiotics in dentistry

This review aims to describe the progress of the probiotic associated with its use in dentistry to treat various infections outside the oral cavity. Infections of the oral cavity ranks sixth most common infections and are often one of the main causes of consultation in dentistry is why it has been treated most bacteria by mechanical procedures that sometimes must be accompanied by an irrational use of antibiotics which have been shown to be causing bacterial resistance and side effects or allergic reactions which is why we have opted promote a healthy environment in order to prevent the development of these infections through the use of multiple strategies, including the use of probiotics in order to achieve and maintain the ecological balance of the biofilm and the potential benefits of these they have already been studied in other areas of health. Correspondence to: Pablo Alejandro Millones Gomez, PhD Student, Universidad Peruana Cayetano Heredia, Lima; Researcher, Universidad Católica Santo Toribio de Mogrovejo. Chiclayo, Perù, E-mail: pablomillones@gmail.com
The Impact of Target Depth on Pointing Performance

An important visual cue for the distance to a target is its binocular depth, the disparity between the left and right eyes. We examined mid-air pointing on a large screen, varying the physical distances (depths) to targets. Welford’s two-part formulation provided a better model than the one-part Fitts’s Law formulation to predict movement time from movement amplitude and target width. Angular measures suggested by Kopper et al. did not improve the model. Consistent variations of Shoemaker et al.’s k-factor suggest target depth plays a role similar to gain for mid-air pointing. We compared both physical and virtual targets to determine if artiﬁcial binocular depth cues induce the same performance as purely physical binocular depth cues. Variation of the k-factor was different when virtual depth and physical depth were not identical. This has implications for calibrating 3-D virtual environments and for the design of interactive 3-D pointing techniques for those environments.
A nationwide population-based case-control study

Objective We conducted a nationwide case-control study in Sweden to test the hypothesis that specific clinical characteristics are associated with increased risk of sudden unexpected death in epilepsy (SUDEP). Methods The study included 255 SUDEP cases (definite and probable) and 1,148 matched controls. Clinical information was obtained frommedical records and the National Patient Register. The association between SUDEP and potential risk factors was assessed by odds ratios (ORs) and 95% confidence intervals (CIs) and interaction assessed by attributable proportion due to interaction (AP). Results Experiencing generalized tonic-clonic seizures (GTCS) during the preceding year was associated with a 27-fold increased risk (OR 26.81, 95% CI 14.86–48.38), whereas no excess risk was seen in those with exclusively non-GTCS seizures (OR 1.15, 95% CI 0.54–48.38). The presence of nocturnal GTCS during the last year of observation was associated with a 15-fold risk (OR 15.31, 95% CI 9.57–24.47). Living alone was associated with a 5-fold increased risk of SUDEP (OR 5.01, 95% CI 2.93–8.57) and interaction analysis showed that the combination of not sharing a bedroom and having GTCS conferred an OR of 67.10 (95% CI 29.66–151.88), with AP estimated at 0.69 (CI 0.53–0.85). Among comorbid diseases, a previous diagnosis of substance abuse or alcohol dependence was associated with excess risk of SUDEP. Conclusions Individuals with GTCS who sleep alone have a dramatically increased SUDEP risk. Our results indicate that 69% of SUDEP cases in patients who have GTCS and live alone could be prevented if the patients were not unattended at night or were free from GTCS. RELATED ARTICLE Patient Page Sudden unexpected death in epilepsy: Assessing the risk factors Page e436
Physical development of hockey players aged 13-16 years

Цель. Выявить возрастные особенности физического развития хоккеистов 13-16 лет. Материал и методы. Обследовано элитные хоккеисты (n=83, возраст - 13-16 лет). Применялись стандартные антропометрические методы измерения длины и массы тела. Рассчитывался индекс массы тела (BMI). Результаты. Среднее значение длины тела хоккеистов не отличалось относительно сверстников, не занимающихся спортом. Центильное распределение абсолютных значений показателя относительно номограмм было сдвинуто вправо. Большинство хоккеистов имели средние показатели длины тела. Было зафиксировано превышение средней массы тела хоккеистов по сравнению со среднепопуляционными значениями. Центильное распределение абсолютных значений характеризовалось значительным сдвигом вправо (диапазон 3%-90% перцентиль). Большинство хоккеистов имели массу тела «выше среднего» (55-66%). Группа атлетов с массой тела и BMI «ниже среднего» составила 6% (возраст от 13 лет до 15 лет). Выводы. Физическое развитие элитных хоккеистов характеризуется средней длиной тела с тенденцией сдвига к значениям *выше среднего*. Доля хоккеистов со значениями длины тела ниже среднепопуляционных очень мала. Элитные хоккеисты отличаются большими значениями массы тела и BMI по сравнению со сверстниками, не занимающимися спортом. По мере увеличения возраста из морфологических критериев наибольшее значение для успешности хоккеиста в спортивном отборе имеет масса тела и BMI.
δ′-Potentials Supported on Hypersurfaces

Self-adjoint Schrödinger operators with δ and δ′-potentials supported on a smooth compact hypersurface are defined explicitly via boundary conditions. The spectral properties of these operators are investigated, regularity results on the functions in their domains are obtained, and analogues of the Birman–Schwinger principle and a variant of Krein’s formula are shown. Furthermore, Schatten–von Neumann type estimates for the differences of the powers of the resolvents of the Schrödinger operators with δ and δ′-potentials, and the Schrödinger operator without a singular interaction are proved. An immediate consequence of these estimates is the existence and completeness of the wave operators of the corresponding scattering systems, as well as the unitary equivalence of the absolutely continuous parts of the singularly perturbed and unperturbed Schrödinger operators. In the proofs of our main theorems we make use of abstract methods from extension theory of symmetric operators, some algebraic considerations and results on elliptic regularity.
Pre-inversion normal fault geometry controls inversion style and magnitude, Farsund Basin, offshore southern Norway

Abstract. Compressional strains may manifest along pre-existing structures within the lithosphere, far from the plate boundaries along which the causal stress is greatest. The style and magnitude of the related contraction is expressed in different ways, depending on the geometric and mechanical properties of the pre-existing structure. A three-dimensional approach is thus required to understand how compression may be partitioned and expressed along structures in space and time. We here examine how post-rift compressional strains are expressed along the northern margin of the Farsund Basin during Late Cretaceous inversion and Palaeogene–Neogene pulses of uplift. At the largest scale, stress localises along the lithosphere-scale Sorgenfrei-Tornquist Zone, where it is expressed in the upper crust as hangingwall folding, reverse reactivation of the basin-bounding normal fault, and bulk regional uplift. The geometry of the northern margin of the basin varies along strike, with a normal fault system passing eastward into an unfaulted ramp. Late Cretaceous compressive stresses, originating from the convergence between Africa, Iberia, and Europe, selectively reactivated geometrically simple, planar sections of the fault, producing hangingwall anticlines and causing long-wavelength folding of the basin fill. The amplitude of these anticlines decreases upwards due to tightening of pre-existing fault propagation folds at greater depths. In contrast, later Palaeogene–Neogene uplift is accommodated by long-wavelength folding and regional uplift of the entire basin. Subcrop mapping below a major, uplift-related unconformity and borehole-based compaction analysis show that uplift increases to the north and east, with the Sorgenfrei-Tornquist Zone representing a hinge line rather than a focal point to uplift, as was the case during earlier Late Cretaceous compression. We show how compressional stresses may be accommodated by different mechanisms within structurally complex settings. Furthermore, the prior history of a structure may also influence the mechanism and structural style of shortening that it experiences.
Penta-Helix and Quintuple-Helix in the Management of Tourism Villages in Yogyakarta City

Each country is currently focusing on developing tourism, considering its impact on economic growth and people’s welfare. Yogyakarta is one of the regions with diverse tourist destinations. The majority of tourist destinations in Yogyakarta city promote arts and culture as tourism icons, including tourism village destinations. However, tourism villages in the city have not fully received tourist attention. Therefore, solutions are required to be found to optimize tourism management and significantly increase the number of tourist visits. This paper aimed to describe the interaction between the government, the tourism industry, higher education institution, media, society, and environment in the tourism village management in Yogyakarta city. The discussion results describe that tourism village management requires synergistic interaction from some elements covering the government, tourism industry, higher education institution, media, society, and environment. The interaction can at least be a solution in improving the quality of tourism village management. Triple-Helix focuses on interactions among higher education institution, industry, and government on innovation. Quadruple-Helix adds the fourth helix, namely culture and media-based public. Quintuple-Helix is a collaboration of elements contained in the Quadruple-Helix with the addition of the natural environment of society. Penta-Helix adds the media element. With the presence of the government, tourism industry, higher education institution, media, society, and environment that interact with each other, the management of tourism villages in Yogyakarta city becomes more optimal and attract more tourists to visit. 5 JEL classification: L32, Z33
Gross morphometric findings of udder and teat in madras red ewes

The objective of the present study was to assess the morphology and morphometric measurements in lactating and non-lactating (n=15 each) Madras Red ewes. In both the groups, udder was located in the inguinal region. It consisted of two mammary glands (right and left halves) divided by an intermammary groove and each had a single teat. In Madras Red ewes, udder circumference (UC) and inter-teat distance (ITD) showed statistically significant difference between lactating and non-lactating ewes. Udder length (UL), width of right (R-UW) and left (L-UW) quarter, udder thickness (UT), Right and left teat length (TL), teat diameter at base (TDB), teat diameter at tip (TDT), teat to floor distance (TFD), teat end to floor distance (TEFD) does not shown any statistical difference between lactating and non-lactating animals.
Online Consumer Behaviour and Opportunities–A Birds Eye View

The underlying concepts and the basis behaviour of consumers in the Internet market are discussed in this paper, showing that online behaviour does not always follow the traditional behaviour. The current knowledge of online consumers is limited and therefore this research is an attempt to explore this phenomenon. In addition to academia, understanding consumers and their decision-making journey is of importance to e-businesses in order to facilitate and influence consumers’ purchase processes. This knowledge can be used to reach consumers “in the right place at the right time with the right message”. In order to win customers in the online market place, where all the competitors and their products are readily accessible, companies require a comprehensive understanding of their customers. E-businesses have encountered challenges in addressing consumer needs and utilizing the capabilities of this environment to the maximum. Little is yet known about the way consumers make purchase decisions, search, and use information in this environment. Online consumers behave differently and also have more sophisticated needs. They are not only buyers but also Internet users. They perform the purchase-related tasks to fulfill a purchase as they would with a traditional retailer. In addition, they require interacting with the Internet while directing the process on their own. Their behaviour is affected by general purchase-related factors and also their interactions with the Internet environment. It is, therefore, crucial to understand their requirements and concerns due to the nature of the online environment. This knowledge can then be used to enhance the shopping experience and provide instant personalization based on the knowledge of consumer.
General Forms of Solutions for Linear Impulsive Fuzzy Dynamic Equations on Time Scales

A class of linear impulsive fuzzy dynamic equations on time scales is considered by using the generalized differentiability concept on time scales. Some novel criteria and general forms of solutions are established for such models whose significance lies in proposing the possibility to get unifying forms of solutions for discrete and continuous dynamical systems under uncertainty and to unify corresponding problems in the framework of fuzzy dynamic equations on time scales. Finally, some examples show the applicability of our results.