Miracle-dz/UniFAR-FTUs huggingface dataset:
TAM Applied for Serious Video Games: A Systematic Literature Review

Since their inception, video games have greatly interested different types of users and organizations, and the academy is not an exception. The principal purpose of serious video games in the academy is to discover new ways to interact with students and strengthen learning and teaching. Video games in education are constantly used in a greater scope to improve the educational process. On the other hand, it is essential to consider the characteristics that must be considered in these types of tools so that they fulfil their purpose without neglecting the interest and motivation of the player. The objective of this work was to perform a systematic review of the topic “technological acceptance models (TAM) applied to serious video games”. The investigation was done by performing searches in 6 scientific libraries to obtain a corpus of papers published between 2015 and 2021. Consequently, a lexical analysis was performed, and 4 clusters were identified about this topic: i) Emotions, social influence, and gratifications; ii) Structural equations; iii) Educational challenges with technology, and iv) The technology acceptance model.
Parental Divorce and Adolescent Drunkenness: Role of Socioeconomic Position, Psychological Well-Being and Social Support

Background: The aim of this cross-sectional study was to explore the association between parental divorce and adolescent drunkenness in the last 4 weeks and the contribution of socioeconomic position, family structure, social support from family and well-being to this association. Methods: We obtained data on 3,694 elementary school students from several cities in Slovakia (mean age 14.3, 49.0% males; response rate 93%). Respondents completed questionnaires on how often they had been drunk in the last 4 weeks, whether their parents were divorced, their socioeconomic position (education of parents, family affluence), the composition of the household (one or two parents/step-parents), social support from the family and their own well-being. Results: Parental divorce was found to have an effect on adolescent drunkenness in the last 4 weeks, as well as high socioeconomic position, low social support from the family and high depression/anxiety. The effect of divorce on drunkenness decreased only slightly after adding social support into the model. Conclusion: Our findings indicate that parental divorce has a persistent influence on risk behavior independent of the influence of socioeconomic position and well-being. Parental divorce may increase the likelihood of drunkenness more than other factors such as low parental support and poor socioeconomic position.
A Deep Learning Approach to Classify and Detect Defects in the Components Manufactured by Laser Directed Energy Deposition Process

This paper presents a deep learning approach to identify and classify various defects in the laser-directed energy manufactured components. It mainly focuses on the Convolutional Neural Network (CNN) architectures, such as VGG16, AlexNet, GoogLeNet and ResNet to perform the automated classification of defects. The main objectives of this research are to manufacture components using the laser-directed energy deposition process, prepare a dataset of horizontal wall structure, vertical wall structure and cuboid structure with three defective classes such as voids, flash formation, and rough textures, and one non-defective class, use this dataset with a deep learning algorithm to classify the defect and use the efficient algorithm to detect defects. The next objective is to compare the performance parameters of VGG16, AlexNet, GoogLeNet and ResNet used for classifying defects. It has been observed that the best results were obtained when the VGG16 architecture was applied to an augmented dataset. With augmentation, the VGG16 architecture gave a test accuracy of 94.7% and a precision of 80.0%. The recall value is 89.3% and an F1-Score is 89.5%. The VGG16 architecture with augmentation is highly reliable for automating the defect detection process and classifying defects in the laser additive manufactured components.
Whole-Exome Sequencing Reveals High Mutational Concordance between Primary and Matched Recurrent Triple-Negative Breast Cancers

Purpose: Triple-negative breast cancer (TNBC) is a molecularly complex and heterogeneous breast cancer subtype with distinct biological features and clinical behavior. Although TNBC is associated with an increased risk of metastasis and recurrence, the molecular mechanisms underlying TNBC metastasis remain unclear. We performed whole-exome sequencing (WES) analysis of primary TNBC and paired recurrent tumors to investigate the genetic profile of TNBC. Methods: Genomic DNA extracted from 35 formalin-fixed paraffin-embedded tissue samples from 26 TNBC patients was subjected to WES. Of these, 15 were primary tumors that did not have recurrence, and 11 were primary tumors that had recurrence (nine paired primary and recurrent tumors). Tumors were analyzed for single-nucleotide variants and insertions/deletions. Results: The tumor mutational burden (TMB) was 7.6 variants/megabase in primary tumors that recurred (n = 9); 8.2 variants/megabase in corresponding recurrent tumors (n = 9); and 7.3 variants/megabase in primary tumors that did not recur (n = 15). MUC3A was the most frequently mutated gene in all groups. Mutations in MAP3K1 and MUC16 were more common in our dataset. No alterations in PI3KCA were detected in our dataset. Conclusions: We found similar mutational profiles between primary and paired recurrent tumors, suggesting that genomic features may be retained during local recurrence.
Análisis del sistema de partición activa del plásmido pSM19035 de "Streptococcus pyogenes"

pSM19035-encoded w protein forms a dimer (w2) that binds to a set of 7-bp repeats with sequence 5¢NATCACN-3¢. Upon binding to its cognate sites, w2 regulates transcription of genes required for copy number control and stable inheritance of plasmids, and promotes accurate plasmid segregation. Protein w2 binds poorly to one heptad but the af®nity to DNA increases with two and more unspaced heptads in direct or inverted orientation. DNA titration of increasing numbers of heptads with w2, monitored by circular dichroism measurements, indicates the binding of one w2 to one heptad (w2:heptad stoichiometry of 1:1). Spacing of two directly or inversely oriented heptads by 1 to 7 bp reduces the af®nity of the protein for its cognate target site. The binding af®nity of w2 for two directly repeated heptads was severely reduced if one of the base pairs of the core 5¢-ATCAC-3¢ sequence of one of the heptads was individually substituted by any other base pair. Hydroxyl radical footprinting shows a protection pattern at the 5¢-ATCAC-3¢ core. These data suggest that each heptad de®nes an operator half-site and that tight binding of the symmetric w2 to the central 5¢-TCA-3¢ core of symmetric or asymmetric targets (differently oriented heptads) is probably achieved by structural changes of DNA and/or protein or both.
Water entry of spheres with various contact angles

It is well known that the water entry of a sphere causes cavity formation above a critical impact velocity as a function of the solid–liquid contact angle; Duez et al. (Nat. Phys., vol. 3 (3), 2007, pp. 180–183). Using a rough sphere with a contact angle of $120^{\circ }$ , Aristoff & Bush (J. Fluid Mech., vol. 619, 2009, pp. 45–78) showed that there are four different cavity shapes dependent on the Bond and Weber numbers (i.e., quasistatic, shallow, deep and surface). We experimentally alter the Bond number, Weber number and contact angle of smooth spheres and find two key additions to the literature: (1) cavity shape also depends on the contact angle; (2) the absence of a splash crown at low Weber number results in cavity formation below the predicted critical velocity. In addition, we use alternate scales in defining the Bond, Weber and Froude numbers to predict the cavity shapes and scale pinch-off times for various impacting bodies (e.g., spheres, multidroplet streams and jets) on the same plots, merging the often separated studies of solid–liquid and liquid–liquid impact in the literature.
How attentional resources of the same or across sensory modalities and task load affect cognitive performance? A multi-sensory integration study

ABSTRACT This study examined how attentional resources of the same or across sensory modalities with varying levels of task load affect cognitive performance. A total of 120 young adults completed an experiment that simultaneously processed either visual–visual (V–V) or visual–auditory (V–A) stimuli. A mixed ANOVA revealed that performance in the V–V experiment was superior to the V–A experiment. Furthermore, performance was significantly better for single tasks relative to dual tasks. The interaction effect showed that increased task load significantly impacted the performance in the V–V experiment but not in the V–A experiment. The findings implied that multi-sensory integration is only more manageable when information processing involves the same type of (visual) sensory modality and with low task load, but less effective for high-level attentional tasks even with the same sensory modality. The effectiveness of cross-modal multi-sensory integration can be compromised potentially due to the inhibitory effect of audio over visual information.
Myocardial Priority Promotes Cardiovascular Recovery for Acute Type A Aortic Dissection Combined with Coronary Artery Disease Undergoing Aortic Arch Surgery

The optimal surgical strategy for acute type A aortic dissection (ATAAD) with coronary artery disease (CAD) remains unclear. The goal of this study was to investigate the cardiovascular protective effects of the myocardial priority (MP) strategy or traditional selective cerebral perfusion (SCP) in ATAAD with CAD. A total of 214 adults were analyzed retrospectively, of which 80 underwent the MP strategy intraoperatively. Seventy-nine pairs were propensity-score-matched and divided into SCP and MP groups. The follow-up period ranged from 6 to 36 months. The MP group had a significantly shorter myocardial ischemic time, higher perfusion flow, higher radial artery pressure, and lower incidence of NIRS decrease >20% of the base value, but a longer lower limb circulatory arrest and bypass time than the SCP group. Although similar adverse cardiac and cerebrovascular events were observed in both groups, a shorter posthospital stay, less blood loss and transfusion, higher postoperative hemoglobin, lower creatinine, and higher PaO2/FiO2 were observed in the MP group. Subgroup analysis showed that when the TIMI Risk Score was <4, the MP group had a lower incidence of low cardiac output and lower postoperative cTnI level. The follow-up patients had similar morbidities between the two groups. The novel MP strategy is associated with a shortened myocardial ischemic time, better maintained perfusion of vital organs, and postoperative recovery after surgery for ATAAD combined with non-severe CAD.
The Anatomy of a South African Genocide: The Extermination of the Cape San Peoples

In 1998 David Kruiper, the leader of the aKhomani San who today live in the Kalahari Desert in South Africa, lamented, "We have been made into nothing. " His comment applies equally to the fate of all the hunter-gatherer societies of the Cape Colony who were destroyed by the impact of European colonialism. Until relatively recently, the extermination of the Cape San people has been treated as little more than a footnote to South African narratives of colonial conquest. During the eighteenth and nineteenth centuries, Dutch-speaking pastoralists who infiltrated the Cape interior dispossessed its aboriginal inhabitants. In response to indigenous resistance, colonists formed mounted militia units known as commandos with the express purpose of destroying San bands. This ensured the virtual extinction of the Cape San people. In The Anatomy of a South African Genocide, Mohamed Adhikari examines the history of the San and persuasively presents the annihilation of Cape San society as genocide.
Electrospun Rubber Nanofiber Web-Based Dry Electrodes for Biopotential Monitoring

This study aims to find base materials for dry electrode fabrication with high accuracy and without reducing electrode performance for long-term bioelectric potential monitoring after electroless silver plating. Most applications of dry electrodes that have been developed in the past few decades are restricted by low accuracy compared to commercial Ag/AgCl gel electrodes, as in our previous study of PVDF-based dry electrodes. In a recent study, however, nanoweb-based chlorinated polyisoprene (CPI) and poly(styrene-b-butadiene-b-styrene) (SBS) rubber were selected as promising candidates due to their excellent elastic properties, as well as their nanofibril nature, which may improve electrode durability and skin contact. The electroless silver plating technique was employed to coat the nanofiber web with silver, and silver nanoweb(AgNW)-based dry electrodes were fabricated. The key electrode properties (contact impedance, step response, and noise characteristics) for AgNW dry electrodes were investigated thoroughly using agar phantoms. The dry electrodes were subsequently tested on human subjects to establish their realistic performance in terms of ECG, EMG monitoring, and electrical impedance tomography (EIT) measurements. The experimental results demonstrated that the AgNW dry electrodes, particularly the SBS-AgNW dry electrodes, performed similarly to commercial Ag/AgCl gel electrodes and were outperformed in terms of long-term stability.
Neural Differences in Relation to Risk Preferences during Reward Processing: An Event-Related Potential Study

Inter-individual variability in risk preferences can be reflected in reward processing differences, making people risk-seekers or risk-averse. However, the neural correlates of reward processing in individuals with risk preferences remain unknown. Consequently, this event-related potential (ERP) study examined and compared electrophysiological correlates associated with different stages of reward processing in risk-seeking and risk-averse groups. Individuals scoring in the bottom and top 20% on the Balloon Analogue Risk Task (BART) were deemed risk-averse and risk-seeking, respectively. Participants engaged in a gambling task while their electroencephalogram (EEG) was recorded. Risk-seekers tended to choose high-risk options significantly more frequently than low-risk options, whereas risk-averse individuals chose low-risk options significantly more frequently than high-risk ones. All participants selected the low-risk alternative more slowly than the high-risk option. During the anticipation stage, the low-risk option elicited a relatively attenuated stimulus-preceding negativity (SPN) response from risk-seekers compared to risk-averse participants. During the outcome stage, feedback-related negativity (FRN) increased in risk-seekers responding to greater losses but not in risk-averse participants. These results indicate that ERP components can detect differences in reward processing during risky situations. In addition, these results suggest that motivation and cognitive control, along with their associated neural processes, may play a central role in differences in reward-based behavior between the two groups.
Earthquake Swarm Activity Beneath the Tokaanu-Waihi Geothermal System, Lake Taupo, New Zealand

The hypocenters of 4 earthquake swarms (total of 54 events), recorded with a local network between 1986 April and 1987 January, occur within upper crustal rocks of the deeper Tokaanu-Waihi geothermal reservoir; all the events had a magnitude M{sub L} {le} 3.2. Most foci are aligned along two NW-trending basement fault structures along which young rhyodacitic extrusions can be found. The swarm activity has been interpreted in terms of injections into basement fractures of magma from deeper chambers (dyke injection swarm activity).
The Ins and Outs of Clusterin: Its Role in Cancer, Eye Diseases and Wound Healing

Clusterin (CLU) is a glycoprotein originally discovered in 1983 in ram testis fluid. Rapidly observed in other tissues, it was initially given various names based on its function in different tissues. In 1992, it was finally named CLU by consensus. Nearly omnipresent in human tissues, CLU is strongly expressed at fluid–tissue interfaces, including in the eye and in particular the cornea. Recent research has identified different forms of CLU, with the most prominent being a 75–80 kDa heterodimeric protein that is secreted. Another truncated version of CLU (55 kDa) is localized to the nucleus and exerts pro-apoptotic activities. CLU has been reported to be involved in various physiological processes such as sperm maturation, lipid transportation, complement inhibition and chaperone activity. CLU was also reported to exert important functions in tissue remodeling, cell–cell adhesion, cell–substratum interaction, cytoprotection, apoptotic cell death, cell proliferation and migration. Hence, this protein is sparking interest in tissue wound healing. Moreover, CLU gene expression is finely regulated by cytokines, growth factors and stress-inducing agents, leading to abnormally elevated levels of CLU in many states of cellular disturbance, including cancer and neurodegenerative conditions. In the eye, CLU expression has been reported as being severely increased in several pathologies, such as age-related macular degeneration and Fuch’s corneal dystrophy, while it is depleted in others, such as pathologic keratinization. Nevertheless, the precise role of CLU in the development of ocular pathologies has yet to be deciphered. The question of whether CLU expression is influenced by these disorders or contributes to them remains open. In this article, we review the actual knowledge about CLU at both the protein and gene expression level in wound healing, and explore the possibility that CLU is a key factor in cancer and eye diseases. Understanding the expression and regulation of CLU could lead to the development of novel therapeutics for promoting wound healing.
Relationships Between Disease Severity and the C-reactive Protein/Albumin Ratio and Various Hematological Parameters in Patients With Acne Vulgaris

Objective: Acne vulgaris, an inflammatory disease, was investigated in this study with the claim that the C-reactive protein (CRP)/albumin ratio and some hematological parameter ratios have the potential to be used as inflammatory markers to monitor disease severity and prognosis. Methods: A descriptive cross-sectional study was conducted with two groups of patients aged 18-65 years, 61 patients diagnosed with acne vulgaris and 35 healthy control patients, and routine hemogram and biochemical parameters were compared. The Global Acne Severity Index was used to determine the severity of acne vulgaris. Results: The median age of acne patients was 22.0 (IQR=5.0) and the median age of healthy volunteers was 30.0 (IQR=14.0). There were 75.4% (n=46) women in the acne group and 77.1% (n=27) women in the control group. Among the acne patients, 42.6% (n=26) had mild acne, and 41% (n=25) had moderate acne severity. A significant difference was found between the study groups in terms of CRP/albumin ratio, CRP, monocyte/lymphocyte ratio (MLR), lymphocyte/albumin ratio (LAR), and monocyte/CRP ratio (MCR) according to laboratory test results and calculated test ratios (p<0.05). The area under the curve (AUC) value of the CRP/albumin ratio in the receiver operating characteristic (ROC) analysis between the acne and control groups was 0.660, and its cut-off value was found to be 0.236 with 68.6% sensitivity and 68.9% specificity. Conclusion: This study is the first to compare the CRP/albumin ratio with the severity of acne vulgaris in the literature. CRP/albumin ratio and MCR may serve as inflammatory markers that can be used to monitor the severity of acne vulgaris.
Content Biases in the Cultural Transmission and Evolution of Urban Legends

This thesis examines the role of cognitive content biases in cultural transmission. The concept of cognitive content biases suggests that humans preferentially attend to, recall and transmit certain types of information over others, and that this bias influences the transmission and evolution of cultural artefacts. A number of studies are presented which primarily use genuine urban legends as material. In using ‘real world’ material such as urban legends these studies expand our knowledge of how content biases operate and shed light on the cultural success of these legends. Methodology included qualitative analyses, experiments using participants in linear transmission chains and computational phylogenetic techniques. The studies demonstrate that content biases are an effective force in cultural transmission but that different biases may not necessarily operate in exactly the same manner. It is argued that the cultural success of urban legends can be explained by their exploitation of cognitive content biases. The studies also demonstrate the efficacy of using ‘real-world’ material such as urban legends in the examination of the mechanisms of cultural transmission and evolution.
The Impact of Moderate Hypophosphatemia on the Clinical Management of Primary Hyperparathyroidism

Background and objective The impact of moderate hypophosphatemia (hypoP) on primary hyperparathyroidism (PHPT) and its use as an independent surgical criterion has not been adequately evaluated in the literature. In light of this, we conducted this study to address the scarcity of data on this topic. Methods We conducted a retrospective evaluation of data related to 164 (133 females and 31 males) patients with PHPT who met the criteria for inclusion in the study. HypoP, which is indicated by phosphorus (P) levels lower than 2.5 mg/dL, was found in 78 (47.5%) patients, and moderate hypoP (1-1.99 mg/dL) was found in 25 patients (15.2%). Results PHPT severity was worse in hypoP patients than non-hypoP patients, as evidenced by higher levels of mean serum calcium (12.9 ±1.0 mg/dL vs. 11.1 ±0.3 mg/dL respectively, p<0.001), parathormone (PTH) [median (interquartile range, IQR): 455.3 (455.3) ng/L vs. 124.0 (84.0) ng/L respectively, p<0.001] and mean 24-hour urinary calcium (414.6 ±168.5 mg/day vs. 291.5 ±161.4 mg/day respectively, p=0.026) as well as lower levels of mean BMI (25.6 ±3.9 kg/m2 vs. 29.0 ±4.0 kg/m2 respectively, p=0.18) and mean 25-hydroxy vitamin D3 (13.8 ±7.3 µg/L vs. 18.2 ±7.8 µg/L respectively, p=0.001). Among the whole study population as well as among patients with Ca levels <1.0 mg/dL according to the upper limit of normal, P level was determined to be an independent factor affecting the indication for surgical treatment [β: -1.96,p=0.038, odds ratio (OR): 0.14, 95% confidence interval (CI): 0.02-0.89 and β: -2.3, p=0.034, OR: 0.10, 95% CI: 0.12-0.84 respectively]. Conclusion We found a strong correlation between moderate hypoP and the severity of the biochemical manifestations of PHPT. In asymptomatic PHPT patients, moderate hypoP was predictive of surgical indication, independent of age and level of hypercalcemia.