Miracle-dz/UniFAR-FTUs huggingface dataset:
Return to School Outcomes among Adults with TBI One Year After Rehabilitation Discharge: A TBIMS Study

ABSTRACT Objective To examine return to school outcomes 1 year after traumatic brain injury (TBI) rehabilitation discharge. Design Longitudinal observational study using Traumatic Brain Injury Model Systems National Database (TBIMS-NDB) data at 1-year post-TBI. Setting Inpatient rehabilitation centers using follow-up telephone calls. Individuals Individuals (n = 237) enrolled in the TBIMS-NDB since 2001 between the ages of 18 and 59 years who were engaged in postsecondary education (full or part-time) before recorded TBI. Main Measures Return to school, categorized as in a postsecondary setting at first follow-up (reported hours in school greater than zero at one-year follow-up). Results Using an alpha level of 0.05 binary logistic regression analysis identified four predictive variables. Significant predictors of return to school include being of lower age, possessing a higher level of functioning at discharge, reporting lower ratings of disability at discharge, and being able to use a vehicle independently for transportation. Conclusion Pursuit of higher education is a viable means of community reintegration after TBI. Some individuals with TBI face a myriad of barriers and challenges when returning to school. Study findings may facilitate understanding of how TBI affects return to school and community reintegration outcomes.
Bilateral Alterations in Isokinetic Strength and Knee Biomechanics During Side-Cutting 1 Year After Unilateral ACL Reconstruction

Background: Individuals with anterior cruciate ligament (ACL) reconstruction (ACLR) are a population that has a higher risk for ACL injury compared with the general population. To reduce the reinjury rate and improve the rehabilitation outcome after ACLR, risk factors for ACL injury have to be addressed. Purpose: To compare the knee biomechanics during side-cutting and isokinetic strength of the thigh muscle of the reconstructed leg with those of the contralateral leg and healthy controls and investigate the knee movement asymmetries in individuals with ACLR. Study Design: Controlled laboratory study. Methods: A total of 16 participants with ACLR (ACLR group; 11.8 ± 1.1 months after reconstruction) and 16 healthy controls (control group) were recruited. Landmark coordinates and ground-reaction forces during side-cutting and isokinetic strength of hamstring and quadriceps were collected. Two-way analysis of variance with the mixed design was performed to compare each dependent variable between groups and across legs. Results: The reconstructed leg had a significantly smaller knee flexion angle (P = .004) and less quadriceps strength (P = .003) than the contralateral leg. The knee extension moment and knee external rotation angle were decreased compared with both the contralateral leg (P = .001, P = .003, respectively) and the healthy control leg (P = .001, P = .001, respectively). The ACLR group showed greater knee abduction angles (P = .004) and smaller knee external rotation moments (P = .006) than the control group. The ACLR group also demonstrated greater asymmetries of knee flexion angle (P = .015), knee external rotation angle (P = .001), knee extension moment (P = .013), knee abduction moment (P = .001), and quadriceps strength (P = .046) than the control group. Conclusion: Knee biomechanics in the leg with ACLR were altered mainly in the sagittal plane during side-cutting compared with the contralateral leg. The altered movement patterns between the ACLR and control groups were primarily observed in the frontal and transverse planes. The ACLR group also demonstrated greater asymmetries of sagittal knee movement and concentric quadriceps strength than the control group. Clinical Relevance: Individuals with ACLR showed different alterations in the reconstructed and contralateral leg compared with healthy controls. These results suggest that rehabilitation programs after ACLR should further focus on restoring the knee flexion angle and quadriceps strength. Injury prevention programs need to be further targeted in the altered movement patterns observed between the ACLR and the healthy groups.
Timing and Predictors of Incident Cardiovascular Disease in Systemic Lupus Erythematosus: Risk Occurs Early and Highlights Racial Disparities

Objective Systemic lupus erythematosus (SLE) affects Black people 2 to 3 times more frequently than non-Black people and is associated with higher morbidity and mortality. In total, 4 studies with predominantly non-Black SLE cohorts highlighted that cardiovascular disease (CVD) is no longer primarily a late complication of SLE. This study assessed the timing and predictors of incident CVD in a predominantly Black population-based SLE cohort. Methods Incident SLE cases from the population-based Georgia Lupus Registry were validated as having a CVD event through review of medical records and matching with the Georgia Hospital Discharge Database and the National Death Index. The surveillance period for an incident CVD event spanned a 15-year period, starting from 2 years prior to SLE diagnosis. Results Among 336 people with SLE, 253 (75%) were Black and 56 (17%) had an incident CVD event. The frequency of CVD events peaked in years 2 and 11 after SLE diagnosis. There was a 7-fold higher risk of incident CVD over the entire 15-year period; this risk was 19-fold higher in the first 12 years in Black people as compared to non-Black people with SLE. Black people with SLE (P < 0.001) and those with discoid rash (hazard ratio 3.2, 95% CI 1.4-7.1) had a higher risk of incident CVD events. Conclusion The frequency of incident CVD events peaked in years 2 and 11 after SLE diagnosis. Being Black or having a discoid rash were strong predictors of an incident CVD event. Surveillance for CVD and preventive interventions, directed particularly toward Black people with recent SLE diagnoses, are needed to reduce racial disparities.
Risk of conversion to bipolar disorder in patients with late-onset major depression

To evaluate the impact of age at onset on late-life depression course and on risk of conversion to bipolar disorder (BD). A retrospective chart review of 100 elderly patients (age ≥ 65 years) diagnosed with a moderate-to-severe depressive episode and followed up for at least 18 months was conducted. Among patients affected by major depressive disorder (N = 57), follow-up morbidity differences between those with typical onset depression (TOD) (<60 years) and those with late-onset depression (LOD) (≥60 years) were investigated using Wilcoxon rank-sum test and Cox proportional hazard model. Patients belonging to the LOD group had a significantly lower percentage of follow-up time spent with depressive symptoms compared with patients with TOD (r = 0.36; P = 0.006), but significantly more time spent with (hypo)manic episodes (r = −0.31; P = 0.021). Moreover, LOD was significantly associated with a faster conversion to BD (hazard ratio = 3.05; P = 0.037). Depression first emerging in late life may represent an unstable condition with a high risk to convert to BD. Given the potential clinical implications, further studies on the course of LOD are required.
Coming Out to Family and Friends in the Trans and Gender Diverse Context

ABSTRACT Despite the risks of rejection and discrimination, “coming out” can be an important psychological milestone for transgender (trans) and gender diverse people (TGD). We evaluated the dimensions of identity that predict coming out to family and friends, and the role of social support in explaining the psychosocial benefits associated with coming out. An online survey was completed by 951 TGD adults, 516 (54.3%) who identify as gender binary (164 transwomen and 352 transmen) and 435 (45.7%) who identify as nonbinary. Overall, gender binary TGD people were more likely than nonbinary people to disclose their identity to family and friends. Hierarchical binary logistic regressions further revealed that appearance congruence and strength of TGD identity are associated with disclosure to family, whereas positive TGD identity is associated with disclosure to friends. Path analyses confirmed that coming out is associated with improved resilience, psychological adjustment, and wellbeing, and that social support is a partial mediator of these associations. The results highlight the importance of coming out in the TGD context and suggest that greater access to social support may account for some of these benefits.
Reclaiming Family, Reimaging Queer Relationality

ABSTRACT Family is an important issue in imagining queer modes of existence. In this essay, I argue for a queer relationality that is structured around biogenetic family, a site that is often marginalized and negated in dominant Euro-American queer discourse. Informed by queer of color critique and postcolonial feminism, this essay affirms the relational framework in understanding the everyday struggles of queer subjects. Situated in the context of Chinese society, I investigate a queer relationality that centers ambivalence and inbetweenness as queer modes of positioning, challenging the teleological narrative of queerness that is characterized by oppositionality, singularity, and anti-relationality.
Sulfur and methane oxidation by a single microorganism

Significance Wetlands are the major natural source of methane, an important greenhouse gas. The sulfur and methane cycles in wetlands are linked—e.g., a strong sulfur cycle can inhibit methanogenesis. Although there has historically been a clear distinction drawn between methane and sulfur oxidizers, here, we isolated a methanotroph that also performed respiratory oxidization of sulfur compounds. We experimentally demonstrated that thiotrophy and methanotrophy are metabolically compatible, and both metabolisms could be expressed simultaneously in a single microorganism. These findings suggest that mixotrophic methane/sulfur-oxidizing bacteria are a previously overlooked component of environmental methane and sulfur cycles. This creates a framework for a better understanding of these redox cycles in natural and engineered wetlands.
Changes in Onchocerciasis Ov16 IgG4 Rapid Diagnostic Test Results Over One-Month Follow-up: Lessons for Reading Timeframe and Decision-Making

ABSTRACT. The SD Bioline® IgG4 rapid diagnostic test (RDT) detects IgG4 antibodies induced by the Onchocerca volvulus-specific antigen Ov16. We evaluated the stability of the RDT results over 1 month, at different time points after completion of each assay, using eluted dried blood spots collected in central Cameroon. Agreement coefficients regarding positivity between 30 minutes and 24 hours, 1, 2, 3, and 4 weeks were, 96.4%, 93.4%, 93.3%, 93.2%, and 93.2%, respectively. Between 30 minutes and 24 hours, 3.6% of the 15,444 tests showed inconsistent results with 81.2% of these tests changing from negative to positive, increasing O. volvulus antibody prevalence from 23.9% to 26.2% (P < 0.0001). This change from negative to positive outcome was confirmed at the subsequent timepoints. Depending on the desired accuracy of prevalence estimates, reading time may have to be redefined more strictly.
Comparison of Factors Associated with Myopia among Middle School Students in Urban and Rural Regions of Anhui, China

SIGNIFICANCE The prevention and control of myopia have become a major public health task throughout the world. The analysis of the modifiable factors associated with myopia will help in planning concrete strategies that can be widely implemented by schools and families. PURPOSE This study assessed the modifiable factors associated with myopia and compared them between rural and urban regions. METHODS Data were collected from December 2020 to March 2021. A multistage stratified cluster sampling method was used to select 6154 middle school students. All children underwent an eye examination, including visual acuity and cycloplegic refraction. Data on near work, sleep, and outdoor activities were collected in questionnaires. RESULTS The myopia prevalence values in urban and rural regions were 68.1 and 63.7%, respectively (χ2 = 15.57, P < .001). More than 3 hours of homework per day (odds ratio [OR] in urban and rural regions, 1.36 [95% confidence interval {CI}, 1.07 to 1.75] vs. 1.72 [95% CI, 1.43 to 2.07]), 36 to 40 core subjects per week (OR, 1.30 [95% CI, 1.04 to 1.57] vs. 1.42 [95% CI, 1.24 to 1.64]), and going to sleep before 10 o'clock (OR, 0.56 [95% CI, 0.32 to 0.93] vs. 0.50 [95% CI, 0.28 to 0.90]) were significantly associated with myopia in both regions. In contrast, taking breaks during near work was a significant factor in the rural region (<1 hour: OR, 0.57 [95% CI, 0.42 to 0.76]; 1 to 2 hours: OR, 0.63 [95% CI, 0.46 to 0.86]) but not in the urban region. More time outdoors per day was associated with a reduced prevalence of myopia only for urban children (2 to 3 hours: OR, 0.55 [95% CI, 0.31 to 0.97]; >3 hours: OR, 0.38 [95% CI, 0.19 to 0.75]). CONCLUSIONS Homework loads and the time of going to sleep were associated with myopia for children in both urban and rural regions. However, time outdoors was only associated with myopia in urban regions, and taking breaks during near work was only associated with myopia in rural regions.
Knots and Links

Introduction Codimension one and other matters The fundamental group Three-dimensional PL geometry Seifert surfaces Finite cyclic coverings and the torsion invariants Infinite cyclic coverings and the Alexander invariant Matrix invariants 3-manifolds and surgery on links Foliations, branched covers, fibrations and so on A higher-dimensional sampler Covering spaces and some algebra in a nutshell Dehn's lemma and the loop theorem Table of knots and links References Index.
Lower Preoperative Verbal Memory Performance Is Associated with Delirium after Coronary Artery Bypass Graft Surgery: A Prospective Cohort Study

Abstract Objective Cognitive impairment constitutes one of the major risk factors of delirium after coronary artery bypass graft (CABG) surgery; however, it is unclear whether only patients with global cognitive decline are at increased risk for delirium or if individuals with preserved global cognitive functions but impairments in specific cognitive domains are also more vulnerable to developing delirium. Thus, this study aimed to analyze the neurocognitive status of patients scheduled for CABG surgery with the use of an advanced computerized cognitive battery (CNS Vital Signs) and to investigate possible associations between impaired performance in selective cognitive areas and the risk of postoperative delirium development. Methods The study enrolled 127 participants with a median age of 67 years (IQR: 63–71). Postoperative delirium developed in 32 (25%) patients. Before surgery, the patients were screened for global cognitive impairment with the use of the Mini-Mental State Examination Test, and the individuals were asked to perform the CNS Vital Signs battery to investigate 12 specific cognitive domains. The Confusion Assessment Method and the Memorial Delirium Assessment Scale were used to screen for a diagnosis of delirium postoperatively. Results In multivariate models, a lower score of verbal memory-assessed preoperatively was independently associated with the risk of postoperative delirium development. Other independent predictors of delirium included more advanced age, gender female, depression, postoperative pyrexia, and the presence of extracorporeal circulation. Conclusions As decreased verbal memory constitutes an independent risk factor for postoperative delirium, a verbal memory test may be a useful predictor of postoperative delirium development.
The Art of Progressive Censoring: Applications to Reliability and Quality

Part I: Distribution Theory and Models. - Progressive censoring: Data and models. - Progressive Type-II censoring: Distribution theory. - Further distributional results on progressive Type-II censoring. - Progressive Type-I censoring: Basic properties. - Progressive hybrid censoring: Distributions and properties. - Adaptive progressive Type-II censoring and related models. - Moments of progressively Type-II censored order statistics. - Simulation of progressively censored order statistics. - Information Measures. - Progressive Type-II censoring under non-standard conditions. - Part II: Inference. - Linear estimation in progressive Type-II censoring. - Maximum likelihood estimation in progressive Type-II censoring. - Point estimation in progressive Type-I censoring. - Progressive hybrid and adaptive censoring and related inference. - Bayesian inference for progressively Type-II censored data. - Point prediction from progressively Type-II censored samples. - Statistical intervals for progressively Type-II censored data. - Progressive Type-I interval censored data. - Goodness-of-fit-tests in progressive Type-II censoring. - Counting and quantile processes and progressive censoring. - Nonparametric inferential issues in progressive Type-II censoring. - Part III: Applications in Survival Analysis and Reliability. - Acceptance sampling plans. - Accelerated life-testing. - Stress-strength models with progressively censored data. - Multi-sample models. - Optimal experimental designs. - Part IV: Appendices. - Appendix A: Distributions. - Appendix B: Additional demonstrative datasets. - Notation. - References. - Author index. - Subject index.
Accuracy and reliability of forensic handwriting comparisons

Significance Forensic handwriting examinations are a critical part of the criminal justice system, seeking to determine whether handwritten documents can be attributed to specific writers by comparison to known exemplars. This paper summarizes a 5-y research study designed to assess the accuracy and reliability of forensic handwriting comparison decisions, which is important in assessing scientific validity for admissibility in court. Here we report the results of the largest-scale study yet conducted to measure the accuracy, reproducibility, and repeatability of conclusions made by practicing forensic document examiners when comparing samples selected to span a range of quality, quantity, and attributes found in casework.
Murine CAR19 Tregs suppress acute graft-versus-host disease and maintain graft-versus-tumor responses

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) efficacy is complicated by graft-versus-host disease (GVHD), a leading cause of morbidity and mortality. Regulatory T cells (Tregs) have shown efficacy in preventing GVHD. However, high Treg doses are often required, necessitating substantial ex vivo or in vivo expansion that may diminish suppressor function. To enhance in vivo suppressor function, murine Tregs were transduced to express an anti–human CD19 chimeric antigen receptor (hCAR19) and infused into lethally irradiated, hCD19-transgenic recipients for allo-HSCT. Compared with recipients receiving control transduced Tregs, those receiving hCAR19 Tregs had a marked decrease in acute GVHD lethality. Recipient hCD19 B cells and murine hCD19 TBL12-luciferase (TBL12luc) lymphoma cells were both cleared by allogeneic hCAR19 Tregs, which was indicative of graft-versus-tumor (GVT) maintenance and potentiation. Mechanistically, hCAR19 Tregs killed syngeneic hCD19+ but not hCD19– murine TBL12luc cells in vitro in a perforin-dependent, granzyme B–independent manner. Importantly, cyclophosphamide-treated, hCD19-transgenic mice given hCAR19 cytotoxic T lymphocytes without allo-HSCT experienced rapid lethality due to systemic toxicity that has been associated with proinflammatory cytokine release; in contrast, hCAR19 Treg suppressor function enabled avoidance of this severe complication. In conclusion, hCAR19 Tregs are a potentially novel and effective strategy to suppress GVHD without loss of GVT responses.
Tide-topography interaction

An analytical method is reviewed that enables the construction of two-dimensional topographies for which tidal conversion is absent. The method employs the analogue of conformal mapping to solve the tide-generation problem exactly. In this problem, a spatial hyperbolic equation governs the streamfunction eld that reaches constant values at bottom and surface, and that is subject to a radiation condition far away from any topographic features present. This problem in principle governs both the trapped, nonhydrostatic (depth-dependent) barotropic, as well as propagating, internal wave response. But, employing the mapping, only the former, trapped eld is obtained. For a particular class of localized ridges, we here verify this by constructing the same nonhydrostatic barotropic eld in an entirely independent manner.
Branching patterns of the vascularization and innervation of the primate forelimb

In this study, we investigate the branching patterns of the vascularization and innervation of the primate forelimb by performing detailed dissections of five unembalmed nonhuman primate specimens belonging to five different species, that is, rhesus macaque (Macaca mulatta), white‐handed gibbon (Hylobates lar), Western gorilla (Gorilla gorilla), chimpanzee (Pan troglodytes), and bonobo (Pan paniscus). Results are compared with five embalmed human specimens (Homo sapiens), and anatomical data of previous studies on nonhuman primates are also included to provide a broader comparative framework. The results show that the overall configuration of the forelimb blood vessels and nerves of the different primate species is similar, although some apparent interspecific differences are found. In all nonhuman primates, in contrast to humans, the superficial vena basilica is absent. Moreover, in gorilla, chimpanzee, and bonobo, the superficial vena cephalica is confined to the forearm. In humans, both an arteria interossea anterior and posterior are present, while in nonhuman primates, only an arteria interossea anterior is present, which migrates to the posterior side at the level of the musculus pronator quadratus. For the innervation, the nervus (n.) medianus and n. ulnaris connect in the forearm of the gorilla and macaque. In the gibbon, the brachial plexus shows some differences in the branching pattern at the fasciculus level compared to the other primates. We conclude that the forelimb innervation branching pattern shows some minor differences between the nonhuman primate species, compared to higher plasticity in the vascularization. However, the exact functional implications of these differences still remain unclear. Therefore, more research on a broader range of primate species and sampling more specimens for each taxon are needed.
On one dimensional Quantum Zakharov system

In this paper, we discuss the properties of one dimensional quantum Zakharov system which describes the nonlinear interaction between the quantum Langmuir and quantum ion-acoustic waves. The system with initial data $(E(0),n(0),\partial_t n(0))\in H^k\bigoplus H^l\bigoplus H^{l-2}$ is local well posedness in low regularity spaces. Especially, the low regularity result for $k$ satisfies $-3/4<k\leq -1/4$ is obtained by using the key observation that the convoluted phase function is convex and careful bilinear analysis. The result can not be obtained by using only Strichartz inequalities for "Schr\"{o}dinger" waves.
The dynamics of the plasmasphere

Dynamical simulations have been developed at the Belgian Institute for Space Aeronomy to study the defornlations of the plasmasphere during geomagnetic substonTIs and other variations in the level of geomagnetic activity. These simulations are based on the mechanism of plasma instability for the formation of the plasmapause and on the E5D empirical electric field model. They show the global behavior of the plasmasphere and its dynamics as influenced by the geomagnetic activity variations. The simulations reproduce the development of the plasmaspheric plumes during geomagnetic substorms and their deformations linked to their differential rotation around the Earth.