Miracle-dz/UniFAR-FTUs huggingface dataset:
Clinical prediction rules in acute appendicitis: which combination of variables is more effective at predicting?

BACKGROUND Clinical prediction rules have been designed to reduce variability and improve the diagnostic process. However, there are no unanimous criteria regarding which of them is the most efficient for the diagnosis of acute appendicitis. AIM The primary aim of this study was to assess the diagnostic efficacy of the most commonly used clinical prediction rules. The second aim was to identify the combination of the smallest number of clinical and analytical variables that would allow a cost-effective diagnostic approach. METHODS A retrospective observational study was conducted of 458 patients who were evaluated for right iliac fossa pain between January 2010 and December 2016. The scores tested were Alvarado, AIR, RIPASA, and AAS. Univariate and multiple regressions were used for validation. RESULTS Alvarado one was the most efficient to establish a positive diagnosis of acute appendicitis. However, the most simplified and predictive combination variables included anorexia, white blood cell count > 8275 leukocytes/mL, neutrophilia (> 75%), abdominal pain < 48 h, migrating pain, and temperature out the range of 37-39ºC. CONCLUSIONS A new and effective CPR (HMC score) for predicting appendicitis in patients presenting with the right iliac fossa pain has been established.
Neuroprotection by hypercapnia in brain ischemic injury followed by persistent hypoxia: an in vivo and in vitro experimental study

Backgrounds: Therapeutic hypercapnia was shown to have a potential neuroprotective role in our previous studies in a rat model of ischemia followed by hypoxia; however, it is unknown how hypercapnia affects blood-brain barrier (BBB) function under hypoxic conditions in cerebral ischemia. We aimed to observe the BBB permeability changes in response to cerebral ischemia followed by acute hypoxia or hypercapnic hypoxia using in vivo and in vitro models.Methods: Adult rats underwent unilateral common carotid artery ligation, at 60 min of ligation, they were exposed to systemic hypoxia with ventilation of 15% oxygen (O2) combined with 8% carbon dioxide (CO2) for 180 min. Cerebral blood flow, BBB integrity, infarct volume and behavior were assessed in this study. In vitro, rat brain microvascular endothelial cells (BMECs) were isolated and cultured under O2 (1% or 21%) with or without 15% CO2 for 6 h. Cell viability and transendothelial electrical resistance (TEER) were measured. The ZO-1 and occludin protein levels were explored in BMECs by Western blotting.Results: Arterial blood O2 (PaO2) tensions averaged 56.1 mmHg during simple hypoxia, and arterial blood CO2 tensions (PaCO2) were maintained at normal values or 60–80 mmHg. Hypercapnia treatment significantly reduced brain infarct volume and pathophysiological changes in hypoxic ischemia rats. Furthermore, in the in vitro experiment, hypercapnia significantly improved the growth condition of BMECs, reduced endothelial cell permeability and attenuated the loss of ZO-1 and occludin protein in BMECs induced by hypoxia. Conclusions: Hypercapnia exerts beneficial effects on the BBB permeability in the rat model of hypoxic-ischemic injury and recovers the neurologic status especially within one week, possibly by preventing the loss of tight junction proteins.
Evolution of N2(A3Σu+) in streamer discharges: influence of oxygen admixtures on formation of low vibrational levels

The formation of N2(A3Σu+) metastable species, produced by cathode-directed streamer discharge, was investigated using the technique of laser-induced fluorescence. A triggered single streamer filament was periodically produced in pure nitrogen (and in nitrogen with admixtures of oxygen) at total pressure of 50 Torr and metastable species were monitored during the streamer channel decay in the centre of the discharge gap. We revealed the dynamics of individual vibrational (v = 0–8) levels of N2(A3Σu+) for various oxygen admixtures (0–20%). In pure nitrogen, the observed evolution of the N2(A3Σu+) during the decaying streamer channel is evidence of initial vibrational relaxation of high vibrational levels towards the v = 2 and 3 levels, followed by a delayed increase of terminal (v = 0, 1) levels. A calibration procedure based on the rate of energy-pooling processes was used to place all detected vibronic levels in pure nitrogen on the absolute scale. Population maxima exceeding 1 × 1014 cm−3 were fixed for the v = 2 and 3 vibrational levels, while the lowest v = 0 level reaches only 3 × 1013 cm−3. Populations of v = 2–5 vibrational levels were also estimated for N2 + O2 mixtures after scaling of laser-induced fluorescence signals obtained at various oxygen admixtures. The total N2(A3Σu+) population in an air-like mixture is formed mainly by v = 3–4 vibronic levels with the population maximum of ~3 × 1013 cm−3 fixed at the shortest analyzed delay. This observation, together with the fact that we were unable to detect v = 0 and 1 levels (fluorescence signals below detection threshold), gives a strong evidence of the inhibition of Δv = 2 vibrational relaxation towards terminal v = 0 and 1 levels, causing much lower populations of the lowest v = 0–1 levels. By analyzing data obtained in pure nitrogen and in nitrogen with three different oxygen admixtures, we have estimated the quenching rate constants of N2(A3Σu+, v) + O2 and N2(A3Σu+, v) + N2 processes for v = 2–6 vibrational levels which are consistent with data from the literature. Quenching rate constants for nitrogen reflect the N2(A3Σu+, v) → N2(A3Σu+, v − 2) relaxation process, however the v = 2 rate constant shows a much larger value compared with the published data.
Research Methodology: Prioritization of New Smartphones Using TOPSIS and MOORA

In today's world purchasing a smart phone has become complicated task for the customers due to range of specifications like Battery, Camera, Screen Size, Cost, Performance, etc. To counter this problem we have number of techniques available with us like the multi-criteria decision-making (MCDM), fuzzy logic, etc. We have used TOPSIS (Technique for Order Preference by Similarity to Ideal Solution) and MOORA (Multi-Objective Optimization on the basis of Ratio Analysis). The objective of this study methodology is to obtain an effective and efficient multi criteria decision making (MCDM) approach to evaluate different smart phone alternatives according to consumer preferences and to find out the best optimal smart phone. Main 12 attributes were identified through many literature reviews and discussion with experts from the Indian smart phone industry and consumers. Integrated TOPSIS-MOORA approach is proposed for prioritizing alternatives based on different selected attributes. Five smart phone brands have been selected for evaluation for this methodology. Battery, Camera, Screen Size, Cost and Performance are the top five prioritized factor taken in this study according to consumers point of views. The results obtained by used methodology will be beneficial for the consumers to differentiate between different smart phones of current industries.
Recent advances in clinical periodontal diagnosis and periodontal treatment procedures: A brief review

Periodontal disease, one of the most common oral diseases, is characterized by gingival inflammation and periodontal tissue destruction. The periodontal disease phase is discontinuous, with periods of exacerbation and remission, making diagnosis, and prevention difficult for clinicians. Newer risk factors have been identified, and environmental and genetic factors may have influenced the pattern of disease. This review article highlights about the recent advances used in the diagnosing and treating the disease and throws light on the various available points of care diagnostic devices.
Prevalence and associated factors of antenatal depression among women attending antenatal care follow up at Michu Clinic in Ayder Comprehensive Specialized Hospital, Mekelle, Tigray, Ethiopia 2019.

Background Antenatal depression is a serious mental health problem that can negatively affect the lives of women. Depressive disorders are not only common and chronic among women throughout the world but also the principal source of disability. The scarce information and limited attention to the problem might aggravate the consequence of the problem and can limit the intervention to be taken. So the purpose of the study is to determine the prevalence and associated factors of antenatal depression among women. Methods An institutional based cross sectional study was conducted by systemic random sampling technique among 203 pregnant women following Antenatal care at Michu clinic in Ayder Comprehensive Specialized Hospital from March to June 2019. An interviewer administered Beck Depression Inventory (II) questionnaire was used to assess individual’s depression condition after consent obtained from participants. Data was entered and analyzed by using statically package for social science version 22. Then bivariate regression with p-value ≤0.25 was entered in to multivariate regression with p-value
Concentration Of Survivin In Children With Juvenile Idiopathic Arthritis (JIA): Diagnostic And Prognostic Value – Single Center Study

BACKGROUND: The goal of the study was to assess the diagnostic and prognostic value of survivin in Juvenile Idiopathic Arthritis (JIA). METHODS: Seventy children with JIA – 59 newly diagnosed and 11 biologically treated (46 girls and 17 boys) aged 1.5-18 years and 29 healthy children as a control group, appropriately matched in terms of sex and age, were included into the study. Concentration of survivin was assessed by an ELISA test in serum and also 18 matched synovial fluid samples collected from JIA patients. RESULTS: Children with JIA were divided according to the subtype of the JIA. In 65.7% of patients oligoarthritis was diagnosed. The disease activity was established on the basis of JADAS-27 criteria, distinguishing three levels of inflammatory process activity: low, medium and high. The largest group comprised children of low activity (62.9%) of the disease. The serum concentration of survivin was significantly higher in JIA compared to the controls (p<0.001). Higher concentration of survivin correlated positively with the presence of anti-cyclic citrullinated peptide autoantibodies (ACPA) (p=0.001). In all synovial fluid samples the concentration of survivin was higher than in matched serum (p=0.003). Serum survivin concentration did not statistically significantly change according to radiological damage status or active synovitis assessed by joint ultrasonography. Survivin level was independent of the disease duration time and treatment with TNF-α inhibitors in DMARD’s non-responders. CONCLUSIONS: On the basis of the conducted study, it could be concluded that survivin seem to be an independent biomarker that may be helpful in the diagnosis of JIA. Nevertheless, the higher concentration of survivin is being associated with ACPA positivity, survivin can act as a unique biomarker that identifies an additional group of patients with JIA negative for autoantibodies, even in the early stage of the disease. We have failed to confirm survivin prognostic potential for the active and destructive course of the rheumatoid process, however it is worth to underline that children have better potential for bone regeneration than adults. Survivin measurement should be considered as aiding tool identifying DMARD’s non-responders.
Yield Potential, Economics and Nutrient Uptake of Rabi Sweet Corn (Zea mays saccharata) as Influenced by Varying Plant Densities and Nitrogen Rates

A field experiment was conducted during rabi, 2013-14 on clay loam soil of Agriculture College Farm, Bapatla, Andhra Pradesh, India to study the influence of plant densities and nitrogen rates on yield, economics and nutrient uptake of sweet corn (Zea mays saccharata). The treatments consisted of combination of three planting densities (P1: 1,11,111 plants ha-1, P2: 83,333 plants ha -1 and P3: 66,666 plants ha -1) and four nitrogen levels (N1: 120 kg N ha -1, N2: 170 kg N ha -1, N3: 220 kg N ha -1 and N4: 270 kg N ha -1). Significantly higher value of yield attributes were noticed with planting density of 66,666 plants ha-1 and nitrogen level of 270 kg ha-1. Significant green cob and green fodder yield of sweet corn were recorded at planting density of 83,333 plants ha-1 and 1,11,111 plants ha-1 respectively with the application of 270 kg N ha-1. The maximum nutrient uptake by sweet corn crop and stover was noticed with planting density of 83,333 plants ha-1and 1,11,111 plants ha-1 respectively with the application of 270 kg N ha-1. The highest net returns and B:C ratio were recorded with application of 270 kg N ha-1 at planting density of 83,333 plants ha-1 over all other treatment combinations. Hence, plant density of 83,333 plants ha-1 with nitrogen level of 270 kg N ha-1 should be adopted to obtain the maximum nutrient uptake, green cob yield and net profit from sweet corn in Krishna Agro-climatic zone of Andhra Pradesh. Art ic le History
A Histological and Histochemical Study on Olfactory Bulbs to Detection Amyloid Protein Depositions by Congo-Red and Routine Staining Techniques

In this study, histological and histochemical techniques were used to examine olfactory bulbs in the albino rat male. Thirty male albino rats were split into three age groups (10 animals each) in the current research: Group I: consider as a control group, including adult animals aged 3 months . Group II: include animals aged 6 months. Group III: include animals aged 12 months. The histological architecture of the layers of olfactory bulbs and their main cells was identified by using H & E staining techniques, meanwhile the composition of each layer in albino rat was evident. In the glomerular and mitral cell layer of group III, olfactory bulbs showed reduced neural density. Modified staining with Congo - red was conducted for histochemical studies. Compacted amyloid cores were found in group III animals’ olfactory bulbs, while dispersed amyloid cores were found in group II&III olfactory bulbs’ cortex. The present study adds to our knowledge of the impact of amyloid protein on olfactory bulbs and their prospective neurodegeneration involvement.
Improvement of deconvolution–convolution treatment of axial-divergence aberration in Bragg–Brentano geometry

An improved method to correct observed shift and asymmetric deformation of diffraction peak profile caused by the axial-divergence aberration in Bragg–Brentano geometry is proposed. The method is based on deconvolution–convolution treatment applying scale transform of abscissa, Fourier transform, and cumulant analysis of an analytical model for the axial-divergence aberration. The method has been applied to the powder diffraction data of a standard LaB6 powder (NIST SRM660a) sample, collected with a one-dimensional Si strip detector. The locations, widths and shape of the peaks in the deconvolved–convolved powder diffraction data have been analyzed. The finally obtained whole powder diffraction pattern ranging from 10° to 145° in diffraction angle has been simulated by the Pawley method applying a symmetric Pearson VII peak profile model to each peak with ten background, two peak-shift, three line-width, and two peak-shape parameters, and the Rp value of the best fit has been estimated at 4.4%.
Mechanical response of a megakaryocyte acoustically coupled with a tethered microbubble

In recent years, a growing interest arised for using cavitation microbubbles oscillating in steady state for purposes of sonoporation [1]. The mechanisms commonly proposed for cell membrane permeabilization are the creation of liquid flows (microstreaming) and induced shear stresses on the cell membrane [2], as well as significant cell membrane deformation through push/pull phenomena [3]. We here propose an experimental investigation of the interaction between a wall-attached microbubble and a biological cell. The experimental setup consists of a tank filled with cell culture medium. A megakaryocyte (MK, bone marrow cell) with a mean radius ranging between 20 and 30 �m is maintained by a glass capillary. By means of a micromanipulator, a single MK is mechanically coupled with a single wall-attached oscillating microbubble of comparable size, driven by an ultrasound field. An ultra-fast camera captures the time- resolved description of the bubble-cell interaction at a micro-scale level, and hence the characterization of the cell membrane deformations and the bubble interface oscillations. Then, a broad parametric study aims the pairing up of the sonoporation success (by particles internalization) with specific regime of bubble oscillation and modal deformations. First observations seem to indicate that strong cell membrane stretching is correlated to bubble nonspherical deformations. References [1] H.J. Vos, B. Dollet, M. Versluis, and N. de Jong, Nonspherical shape oscillations of coated microbubbles in contact with a wall, Ultrasound in Medicine & Biology, Vol. 37, No. 6, 2011, pp. 935-948. [2] J. Collis, R. Manasseh, P. Liovic, P. Tho, A. Ooi, K. Petkovic-Duran, and Y. Zhu, Cavitation microstreaming and stress fields created by microbubbles, Ultrasonics, Vol. 50, No. 2, 2010, pp. 273-279. [3] Z. Fan, R.E. Kumon, and C.X. Deng, Mechanisms of microbubble-facilitated sonoporation for drug and gene delivery, Therapeutic Delivery, Vol. 5, No. 4, 2014, pp. 467-486.
Amyloid-beta Uptake by Peripheral Blood Monocytes is Reduced by Ageing and Alzheimer’s Disease

BackgroundDeficits in the clearance of amyloid β-protein (Aβ) play a pivotal role in the pathogenesis of sporadic Alzheimer’s disease (AD). The roles of blood monocytes, the counterpartsof microglia in the periphery, in the development of AD remain unclear. In this study, we sought to investigate the alterations in the Aβ phagocytosis function of peripheral monocytes during ageing and in AD patients. Methods:A total of104 cognitively normal participants aged 22 to 89 years old, 22 AD patients, 22 age- and sex-matched cognitively normal (CN) subjects, 15 Parkinson’s disease patients (PD) and 15 age- and sex-matched CN subjects were recruited. The Aβ uptake by blood monocytes were measured and its alteration during ageing and in AD were investigated. ResultsAβ1-42 uptake by monocytes was associated with Aβ1-42 levels in the blood. Aβ1-42 uptake by monocytes decreased during ageing, and further decreased in AD but not in PD patients. Among the Aβ uptake-related receptors and enzymes, the expression of Toll‑like receptor 2 (TLR2) was reduced in monocytes from AD patients.ConclusionOur findings suggest that monocytes regulate the blood levels of Aβ and might be involved in the development of AD. The recovery of the Aβ clearance function by blood monocytes represents a potential therapeutic strategy for AD.
Experimental study and analytical modeling of an alkaline water electrolysis cell

A traditional alkaline aqueous electrolyzer is investigated by using a 3‐electode structure that enables the reaction resistance of each individual electrode to be accurately monitored. Combining experimental observations with resistance‐based model analysis, we establish a quantitative relationship between current density and key voltage losses, including losses due to thermodynamics, kinetics, ohmic, and mass transport. These results demonstrate that the oxygen evolution reaction and bubble effects play crucial roles in determining electrolyzer performance. By varying the distance between electrodes, 2 effective OH− conductivities in 0.4M KOH are found to be 0.1333 and 0.9650 second cm−1, depending on bubble formation and release rate at the electrode interface. Moreover, bubble coverage on electrode surface achieves a steady state of 96% when current density is above 0.1 A cm−2. In the study of various electrolyte concentrations, all the model predictions show good agreement with experimental results, confirming its ability to capture actual cell performance. This newly presented empirical resistance‐based model provides a practical framework to simulate complicated electrolysis reactions, serving as a comprehensive guide for continuous improvement of water electrolysis.
A Mobile Sensing App to Monitor Youth Mental Health: Observational Pilot Study

Background Internalizing disorders are the most common psychiatric problems observed among youth in Canada. Sadly, youth with internalizing disorders often avoid seeking clinical help and rarely receive adequate treatment. Current methods of assessing internalizing disorders usually rely on subjective symptom ratings, but internalizing symptoms are frequently underreported, which creates a barrier to the accurate assessment of these symptoms in youth. Therefore, novel assessment tools that use objective data need to be developed to meet the highest standards of reliability, feasibility, scalability, and affordability. Mobile sensing technologies, which unobtrusively record aspects of youth behaviors in their daily lives with the potential to make inferences about their mental health states, offer a possible method of addressing this assessment barrier. Objective This study aims to explore whether passively collected smartphone sensor data can be used to predict internalizing symptoms among youth in Canada. Methods In this study, the youth participants (N=122) completed self-report assessments of symptoms of anxiety, depression, and attention-deficit hyperactivity disorder. Next, the participants installed an app, which passively collected data about their mobility, screen time, sleep, and social interactions over 2 weeks. Then, we tested whether these passive sensor data could be used to predict internalizing symptoms among these youth participants. Results More severe depressive symptoms correlated with more time spent stationary (r=0.293; P=.003), less mobility (r=0.271; P=.006), higher light intensity during the night (r=0.227; P=.02), and fewer outgoing calls (r=−0.244; P=.03). In contrast, more severe anxiety symptoms correlated with less time spent stationary (r=−0.249; P=.01) and greater mobility (r=0.234; P=.02). In addition, youths with higher anxiety scores spent more time on the screen (r=0.203; P=.049). Finally, adding passively collected smartphone sensor data to the prediction models of internalizing symptoms significantly improved their fit. Conclusions Passively collected smartphone sensor data provide a useful way to monitor internalizing symptoms among youth. Although the results replicated findings from adult populations, to ensure clinical utility, they still need to be replicated in larger samples of youth. The work also highlights intervention opportunities via mobile technology to reduce the burden of internalizing symptoms early on.
Collection and Conservation of Local Types of Moringa (Moringa oleifera (L.) Trees for Good Sources of Traditional Vegetable

With an objective to conserve the best local types for future generation and purpose of these trees protected from extinction due to national high ways road expansion by the government and local bodies. The collection was made in and around our college about 15 km radius found small tree uniformly good Moringa types are cultivating as kitchen garden tree in front and backside of the home where tribal areas of Tiruvannamalai district. Continues concentration of tagged trees for three years study related to growth habits, fruiting capacity, taste of fruits and market value of fruits, the green pod yield assessment was recorded from the marked trees. Among the tagged trees over three years study, the Vahavachanur 1. Perunduraipattu3, Michealpuram 5, Moongilduraipattu 1 and Vanapuram 3 trees qualities are better for rganoleptically culinary vegetable purpose and also Vzhavachanur1 tree found offseason bearing than other areas trees inclusing selected trees.