Miracle-dz/UniFAR-FTUs huggingface dataset:
Exploring the factors influencing mobile technology integration in higher education

ABSTRACT This study proposed and tested an empirical model to examine the relationships between the factors influencing mobile technology integration in higher education from the students’ and faculty points of view. A sequential mixed method was used to meet the aim of the study. The findings of the qualitative phase were used to develop the quantitative instrument. The participants in the qualitative data collection were 39 students and faculty members. In addition, the participants were 300 graduate students from two large universities in northern Palestine. The findings of the study revealed that the proposed model helps in explaining factors affecting students’ mobile technology integration and exploring relationships between the factors. Furthermore, students’ attitudes and beliefs, the quality of service, patronisation, the cost of service and the instructors had a significant impact on students’ mobile technology integration in higher education.
Situated Visual Alarm Displays Support Machine Fitness Assessment for Nonexplainable Automation

Determine if situated visual alarm displays can support machine fitness assessment (MFA), facilitating improved hazard recognition and alarm accuracy assessment in the presence of inaccurate alarms. Poor performance of opaque automation is more difficult to detect, which increases the likelihood of cascades resulting in overall system failure. MFA reduces the negative impact of poor automation performance. Integrated alarm visualizations were shown to 32 nurses for 10 cases focused on patient outcome and 17 focused on alarm quality, all using real patient data. Five of the ten outcome cases would ultimately result in an emergency (unbeknownst to the nurse). Alarm cases ended with a true, false, or unnecessary alarm. Responses for nurses’ concern, confidence, alarm quality, and intended response were recorded. Qualitative analysis of interviews was performed. Using the situated visual alarm displays, nurses reported less confidence (6.5 vs. 9.1, p < 0.001), more concern (5.4 vs. 1.6, p < 0.001), and more urgent responses for emergency cases. Their alarm event detection was better than the alarms’ detection (0.608 vs. 0.438, p < 0.001), as was their interpretation accuracy (0.453 vs. 0.243, p < 0.001). Nurses showed differentiated concern for emergency cases, nonemergency cases with alarms, and those without alarms (5.4 vs. 3.8 vs. 1.6, p < 0.001). Situated visual alarm displays combining visual trends with alarm signals improves detection of hazardous events and mitigates the negative effects of poor opaque automation performance.
Finite Element Modeling of Vasoreactivity Using COMSOL Multiphysics

Localized calcium events in the endothelial cells (EC) can modulate smooth muscle cell (SMC) calcium (Ca 2+ ) and membrane potential dynamics through release of endothelium derived hyperpolarizing and relaxing factors. Ca 2+ levels in the smooth muscle cell (SMC) determine its contractile state. The underlying complex mechanism regulating the SMC Ca 2+ levels and ultimately vessel tone remains poorly understood. We developed coupled EC-SMC continuum models to describe function at macro-scale level by integrating mechanisms at the subcellular/ molecular level. Cellular models were coupled through diffusion of ions and second messengers. The models allows introduction of spatial distribution of cellular components and micro domains. The model will provide quantification and better understanding of localized events in the EC and its modulation of the vessel tone.
Drug Nanocrystals: Focus on Brain Delivery from Therapeutic to Diagnostic Applications

The development of new drugs is often hindered by low solubility in water, a problem common to nearly 90% of natural and/or synthetic molecules in the discovery pipeline. Nanocrystalline drug technology involves the reduction in the bulk particle size down to the nanosize range, thus modifying its physico-chemical properties with beneficial effects on drug bioavailability. Nanocrystals (NCs) are carrier-free drug particles surrounded by a stabilizer and suspended in an aqueous medium. Due to high drug loading, NCs maintain a potent therapeutic concentration to produce desirable pharmacological action, particularly useful in the treatment of central nervous system (CNS) diseases. In addition to the therapeutic purpose, NC technology can be applied for diagnostic scope. This review aims to provide an overview of NC application by different administration routes, especially focusing on brain targeting, and with a particular attention to therapeutic and diagnostic fields. NC therapeutic applications are analyzed for the most common CNS pathologies (i.e., Parkinson’s disease, psychosis, Alzheimer’s disease, etc.). Recently, a growing interest has emerged from the use of colloidal fluorescent NCs for brain diagnostics. Therefore, the use of NCs in the imaging of brain vessels and tumor cells is also discussed. Finally, the clinical effectiveness of NCs is leading to an increasing number of FDA-approved products, among which the NCs approved for neurological disorders have increased.
Combination of Ascorbic Acid and Menadione Induces Cytotoxic Autophagy in Human Glioblastoma Cells

We investigated the ability of the ascorbic acid (AA) and menadione (MD) combination, the well-known reactive oxidative species- (ROS-) generating system, to induce autophagy in human U251 glioblastoma cells. A combination of AA and MD (AA+MD), in contrast to single treatments, induced necrosis-like cell death mediated by mitochondrial membrane depolarization and extremely high oxidative stress. AA+MD, and to a lesser extent MD alone, prompted the appearance of autophagy markers such as autophagic vacuoles, autophagosome-associated LC3-II protein, degradation of p62, and increased expression of beclin-1. While both MD and AA+MD increased phosphorylation of AMP-activated protein kinase (AMPK), the well-known autophagy promotor, only the combined treatment affected its downstream targets, mechanistic target of rapamycin complex 1 (mTORC1), Unc 51-like kinase 1 (ULK1), and increased the expression of several autophagy-related genes. Antioxidant N-acetyl cysteine reduced both MD- and AA+MD-induced autophagy, as well as changes in AMPK/mTORC1/ULK1 activity and cell death triggered by the drug combination. Pharmacological and genetic autophagy silencing abolished the toxicity of AA+MD, while autophagy upregulation enhanced the toxicity of both AA+MD and MD. Therefore, by upregulating oxidative stress, inhibiting mTORC1, and activating ULK1, AA converts MD-induced AMPK-dependent autophagy from nontoxic to cytotoxic. These results suggest that AA+MD or MD treatment in combination with autophagy inducers could be further investigated as a novel approach for glioblastoma therapy.
Long-Term Risk of Hospitalization for Somatic Diseases Among Survivors of Childhood Acute Lymphoblastic Leukemia

Abstract Background Survivors of childhood acute lymphoblastic leukemia (ALL) may be at increased long-term risk of hospitalization for somatic diseases. However, large population-based cohort studies with risk estimates for survivors successfully cured without experiencing a relapse or requiring hematopoietic stem cell transplantation (HSCT) are lacking. Methods Danish and Swedish patients diagnosed with ALL before age 20 years in 1982-2008 were identified in the national cancer registries. Five-year survivors and matched population comparisons without childhood cancer were followed for hospitalization for 120 somatic disease categories in the national hospital registries from 5 years postdiagnosis until 2017, and disease-specific hospitalization rate ratios (RR) were calculated. The mean cumulative count method was used to estimate the mean number of multiple and recurrent disease-specific hospitalizations per individual. Results A total of 2024 5-year survivors and 9797 population comparisons were included. The overall hospitalization rate was more than twice as high compared with comparisons (RR = 2.30, 95% confidence interval [CI] = 2.09 to 2.52). At 30 years postdiagnosis, the mean cumulative hospitalization count was 1.69 (95% CI = 1.47 to 1.90) per survivor and 0.80 (95% CI = 0.73 to 0.86) per comparison. In the subcohort without relapse or HSCT (n = 1709), the RR was 1.41 (95% CI = 1.27 to 1.58). Conclusions Survivors of childhood ALL were at increased long-term risk for disease-specific hospitalizations; however, in survivors without relapse or HSCT, the rate was only modestly higher than in population comparisons without a childhood cancer. The absolute mean numbers of multiple and recurrent hospitalizations were generally low.
GraphHINGE: Learning Interaction Models of Structured Neighborhood on Heterogeneous Information Network

Heterogeneous information network (HIN) has been widely used to characterize entities of various types and their complex relations. Recent attempts either rely on explicit path reachability to leverage path-based semantic relatedness or graph neighborhood to learn heterogeneous network representations before predictions. These weakly coupled manners overlook the rich interactions among neighbor nodes, which introduces an early summarization issue. In this article, we propose GraphHINGE (Heterogeneous INteract and aggreGatE), which captures and aggregates the interactive patterns between each pair of nodes through their structured neighborhoods. Specifically, we first introduce Neighborhood-based Interaction (NI) module to model the interactive patterns under the same metapaths, and then extend it to Cross Neighborhood-based Interaction (CNI) module to deal with different metapaths. Next, in order to address the complexity issue on large-scale networks, we formulate the interaction modules via a convolutional framework and learn the parameters efficiently with fast Fourier transform. Furthermore, we design a novel neighborhood-based selection (NS) mechanism, a sampling strategy, to filter high-order neighborhood information based on their low-order performance. The extensive experiments on six different types of heterogeneous graphs demonstrate the performance gains by comparing with state-of-the-arts in both click-through rate prediction and top-N recommendation tasks.
A new flat shell finite element for the linear analysis of thin shell structures

Abstract In this paper, a new rectangular flat shell element denoted ‘ACM_RSBE5’ is presented. The new element is obtained by superposition of the new strain-based membrane element ‘RSBE5’ and the well-known plate bending element ‘ACM’. The element can be used for the analysis of any type of thin shell structures, even if the geometry is irregular. Comparison with other types of shell elements is performed using a series of standard test problems. A correlation study with an experimentally tested aluminium shell is also conducted. The new shell element proved to have a fast rate of convergence and to provide accurate results.
Promotion of Ru or Ni on Alumina Catalysts with a Basic Metal for CO2 Hydrogenation: Effect of the Type of Metal (Na, K, Ba)

Ru and Ni on alumina catalysts have been promoted with a 10 wt% of alkali metal (K or Na) or alkaline earth metal (Ba) and tested in CO2 methanation. For the catalyst consisting of Ni and Ba, the variation of Ba loading while keeping Ni loading constant was studied. The promotion in terms of enhanced CH4 yield was found only for the addition of barium to 15 wt% Ni/Al2O3. In contrast, K and Na addition increased the selectivity to CO while decreasing conversion. For the Ru-based catalyst series, no enhancement in conversion or CH4 yield was attained by any of the alkaline metals. CO2 temperature-programed desorption (CO2-TPD) revealed that the amount of chemisorbed CO2 increased significantly after the addition of the base metal. The reactivity of COx ad-species for each catalyst was assessed by temperature-programed surface reaction (TPSR). The characterization revealed that the performance in the Sabatier reaction was a result of the interplay between the amount of chemisorbed CO2 and the reactivity of the COx ad-species, which was maximized for the (10%Ba)15%Ni/Al2O3 catalyst.
Trimethylamine N-Oxide (TMAO) and Trimethylamine (TMA) Determinations of Two Hadal Amphipods

Hadal trenches are a unique habitat with high hydrostatic pressure, low temperature and scarce food supplies. Amphipods are the dominant scavenging metazoan species in this ecosystem. Trimethylamine (TMA) and trimethylamine oxide (TMAO) have been shown to play important roles in regulating osmotic pressure in mammals, hadal dwellers and even microbes. However, the distributions of TMAO and TMA concentrations of hadal animals among different tissues have not been reported so far. Here, the TMAO and TMA contents of eight tissues of two hadal amphipods, Hirondellea gigas and Alicella gigantea from the Mariana Trench and the New Britain Trench, were detected by using the ultrahigh performance liquid chromatography–mass spectrometry (UPLC-MS/MS) method. Compared with the shallow water Decapoda, Penaeus vannamei, the hadal amphipods possessed significantly higher TMAO concentrations and a similar level of TMA in all the detected tissues. A higher level of TMAO was detected in the external organs (such as the eye and exoskeleton) for both of the two hadal amphipods, which indicated that the TMAO concentration was not evenly distributed, although the same hydrostatic pressure existed in the outer and internal organs. Moreover, a strong positive correlation was found between the concentrations of TMAO and TMA in the two hadal amphipods. In addition, evolutionary analysis regarding FMO3, the enzyme to convert TMA into TMAO, was also conducted. Three positive selected sites in the conserved region and two specific mutation sites in two conserved motifs were found in the A. gigantea FMO3 gene. Combined together, this study supports the important role of TMAO for the environmental adaptability of hadal amphipods and speculates on the molecular evolution and protein structure of FMO3 in hadal species.
Numerical Investigation of Fluid Flow and Heat Characteristics of a Roughened Solar Air Heater with Novel V-shaped Ribs

Solar air heaters convert clean solar energy into useful heat and have a wide range of applications. Computational Fluid Dynamics (CFD) can aid in the design and development of solar air heaters with optimized thermal efficiency. A detailed numerical study was conducted to investigate the fluid flow and heat transfer characteristics of a roughened solar air heater with novel V-shaped ribs having staggered elements. Three dimensional steady-state numerical simulations were performed using the k– RNG turbulence model, and results were found in excellent agreement with experimental data. The effect of ribs spacing were studied through varying the rib pitch to rib height ratio P/e= 6 to 14, for Reynolds numbers (Re) in the range of 4000-14,000. A significant enhancement in the ribs-roughened solar air heater’s thermal performance was observed. It was also established that an increment in P/e from 6 to 10 increases the Nusselt number (Nu) for all Re values investigated. About 72.6% Nu enhancement was predicted for P/e=10 at Re = 12,000. It was further observed that an increment in p/e from 10 to 14 decreases Nu for all Re values considered.
Site of Nerve Division Affects Pain-Related Behavior and Spinal Cord Glial Proliferation after C7 Neurotomy in a Rat Stroke Model

Objective This study aimed to evaluate whether the site of C7 neurotomy affects spinal cord glial cell activation and pain-related behavior on the paralyzed side in a rat stroke model. Methods After middle cerebral artery occlusion (MCAO) was induced in male Sprague-Dawley rats, they underwent C7 neurotomy 0, 2, and 4 mm distal to the intervertebral foramen on the paralyzed side. Pain-related behavior and immunofluorescence examination of spinal cord glial cell activation in the ipsilateral C7 dorsal horn were evaluated. Results Mechanical paw withdrawal threshold (MPWT) was lower, and the number of microglia and astrocytes (/mm2) was higher as the distance between the site of C7 neurotomy and the intervertebral foramen decreased from 4 mm to 0. Conclusion The site of C7 neurotomy affects MPWT and spinal cord glial proliferation in rats with MCAO. Nerve division closer to intervertebral foramen resulted in lower MPWT and higher degree of glial proliferation in the spinal cord.
Motivated Engineering Transfer Students/STEP after Six Years

Over six years ago, an experiment was launched: Could two engineering professors from a large university in the West successfully interact with five rural community colleges (CCs) in a winwin partnership? The results were successful enough after a one year experiment with three CCs, that a five year effort was funded by the National Science Foundation STEP program for five CCs in 2009. The effort is still successful and evolving in spite of administrative changes at all five CCs. This paper will describe the results of this program and some of the lessons that have been learned. Major goals of this program are to interest and encourage more CC students to consider engineering and computer science for majors. Next, we seek to facilitate the transfer process for these CC students to a large, Research I university. This also includes encouraging and supporting transfer students after they have transferred. This support includes a center for transfer students, center employees who are transfer students to help other transfer students, scholarships, and a two-credit Academic Success and Professional Development Class. At the same time, we have the goal to help build the engineering program at each of the CCs. This paper will summarize program results for the past six years, including successes and major challenges and barriers.
Reduction of Artificial Tears and Use of Adjunctive Dry Eye Therapies After Lifitegrast Treatment: Evidence from Clinical and Real-World Studies

Purpose To assess the frequency of patients reducing the use of artificial tears (ATs) among patients with dry eye disease (DED) following lifitegrast treatment. Patients and Methods Two independent analyses were performed using the data from the 1-year, randomized, multicenter, Phase 3 SONATA trial and a noninterventional, real-world evidence (RWE) study conducted in patients with DED who were treated with lifitegrast in the United States and Canada. In SONATA, patients who had used ATs in the lifitegrast and placebo groups were included. The RWE study reviewed patients’ electronic medical records, prescribing patterns, and practices of physicians throughout the survey. These data were then used to compare the proportion of patients using ATs in the 6-month pre-index period versus the 12-month post-index period. Results Of 293 patients (lifitegrast, n=195; placebo, n=98) from SONATA, 107 (lifitegrast, n=64; placebo, n=43) used ATs during the on-therapy period while 186 (lifitegrast, n=131; placebo, n=55) did not. Of those not using ATs, the proportion of patients in the lifitegrast group at any time was higher (~67% [n=131]) versus placebo (~56% [n=55]); this was the case at all study time-points (Days 90, 180, 270, and 360). The RWE study included 600 patient charts (US, n=550; Canada, n=50); 75.5% (n=453) reported AT use. There was ~40% decrease in the proportion of patients using ATs as adjunct DED therapy to lifitegrast in the post-index period (n=273) versus those in the pre-index period (n=453). Conclusion The findings show that the reliance on AT use can be gradually reduced with lifitegrast treatment, eventually leading to a reduction in disease burden.
Startle Seizures and Diffuse Leukoencephalopathy After Resolution of Herpes Simplex Virus 1 Encephalitis in a Child

We describe a unique clinical presentation of a child after the acute phase of herpes simplex virus 1 (HSV1) encephalitis. A 17-month-old boy first presented with HSV1 encephalitis and was promptly treated with antiviral medication. Seven months later, he was re-admitted for startle seizures. Magnetic Resonance Imaging of the brain showed diffuse confluent leukoencephalopathy. This constellation of symptoms has not been previously reported in HSV1 encephalitis. In conclusion, we showed that brain injury due to HSV1 encephalitis can be associated with the development of startle seizures and diffuse white matter injury in the post-acute phase.
Genome Wide Differential Expression Profiles in Nevus Sebaceous Uncovered Low Expression of CDKN2AIP and Construction of a ceRNA Network

Background Nevus sebaceous (NS) is a benign hamartoma of the skin, characterized by hyperplasia of the epidermis, in addition to immature hair follicles. The exact mechanisms of folliculo-sebaceous-apocrine defects and adnexal tumorigenesis are unknown in NS, but benign and malignant neoplasms are often due to a complex etiology in NS. Long noncoding RNAs (lncRNAs) have been implicated in various important biological processes and regulate inflammatory diseases and tumors. However, the role of lncRNAs in nevus sebaceous is unclear. Objective To identify NS-associated mRNA and lncRNA profiles and predict their potential roles in the development of the folliculo-sebaceous-apocrine unit and adnexal tumorigenesis. Methods RNA-seq was used to identify NS-associated genes and lncRNAs. Analysis software Illumina NovaSeq 6000 was used to analyze the sequences, and real-time PCR and Western blot were used to validate the differentially expressed genes. Competing endogenous RNAs (ceRNA) networks were constructed by prediction software TargetScan & miRanda. Results Many mRNAs were significantly differentially expressed between nevus sebaceous and adjacent normal scalp tissues. Among them, 72 were upregulated and 18 were downregulated. KEGG pathway analysis further revealed that 32 functional pathways were associated with the upregulated mRNAs, while only 1 pathway was associated with the downregulated mRNAs. Verification by real-time PCR and Western blot indicated that CDKN2AIP gene was downregulated consistently in NS tissue compared to normal scalp skin. Additionally, 7 upregulated and 10 downregulated significantly differentially expressed lncRNAs were detected between NS and adjacent normal scalp tissues. Three downregulated lncRNAs including AL355607.2, RP5-1024G6.8 and AC007780.1 were predicted to consistently associate with CDKN2AIP expression by competing endogenous RNAs(ceRNA) construction. Conclusion Both mRNA and lncRNA profiles were altered in NS scalp tissues. We identified a downregulated gene, CDKN2AIP, as a target of differentially expressed mRNA and predicted a ceRNA network of CDKN2AIP with differentially expressed lncRNA.