Miracle-dz/UniFAR-FTUs huggingface dataset:
Morpho-anatomical structure and development of fruit in Asyneuma canescens (Саmpanulaceae)

The most usual fruit type in the family Саmpanulaсеае is an inferior multi-seeded capsule. In Саmpanula and related genera, A. Kolakovsky determined a new type of capsule, characterized by a specialized organ, axicorn. Some types of axicorn capsules were determined depending on the way of dehiscence. In Campanula, capsule dehiscence is called axicorn-fissuricidal mode, while in Asyneuma – axicorn-valvate mode with scaliformis valves. The precise differences between slit and valve so far have not been identified. In this connection, we performed the study of the inner fruit structure and dehiscence in Asyneuma canescens intending to compare the results with those for Саmpanula species. Anatomical fruit structure was studied under a light microscope on temporary preparations of transversal and longitudinal sections. For the first time, the obtained data provide precise characteristics of the inner fruit morphology, the anatomy of the fruit wall, and dehiscence mode in A. canescens. The survey revealed predominance in the ovary of a synascidiate zone with axile placentation. In the anatomical structure of the fruit wall, there we found a parenchymatous mesocarpium, non-lignified exo- and endocarpium, and lignified elements of fruit – axicorns, located in the small upper part of the septa. Fruit dehiscence in A. canescens occurs in two steps. First, during early flower development, narrow-oval dips are formed on the septum radii; during the fruiting period, a hippocrepiform slit at the lower margin of each dip develops. At this time axicorns detach from the central column of the ovary following a curved direction, meaning the formation of the septifragal slit. During the second stage, the longitudinal slits are formed from the lowest point of the hippocrepiform slit to the fruit base. These slits facilitate seed release from the capsule. Fruit in A. canescens we define as an inferior trilocular syncarpous capsule with two-stage, hippocrepiform and laminar dehiscence. Our study confirms resemblance of anatomical structure and dehiscence mode of fruit in A. canescens and species of the section Rapunculus of the genus Cаmpanula with erect capsules. We consider it inexpedient to accept the new fruit type for A. canescens, because differences compared with species of Cаmpanula are derivative and concern the small size of the axicorn slit and the appearance of additional slits only.
BOARD ’ S MONITORING IN EMERGING MARKET

The role of monitoring Board of Commissioners is critical in the mechanism of internal corporate governance, especially within inclined family-owned shares of emerging markets. One of such monitoring activities is the supervision of financial statement presentation. The success in monitoring role may be presented by the low earnings management performed by company executives. It is suggested that, the more effective the monitoring role is, the better firm value will be. This study aims to determine the effect of monitoring role of Board of Commissioners on firm value, and to examine whether family control can moderate the effect of monitoring role on firm value. Our population consists of non-financial service companies listed on Indonesia Stock Exchange 2016-2018. We employed purposive sampling and conducted 356 observations. We tested the data using moderated regression analysis. The result shows that monitoring role cannot affect firm value. Likewise, family control cannot moderate the influence of monitoring role on firm value. The result of this study provides evidence that the role of monitoring cannot operate well within companies whose shareholders are dominated by family. The result of the study also proves that internal control in companies from developed countries cannot be applied to companies in emerging market.
Regulation of redox processes in biological systems with the participation of the Keap1/Nrf2/ARE signaling pathway, biogenic selenium nanoparticles as Nrf2 activators

The article is devoted to the mechanisms of regulation of redox processes in cells, a review of the Keap1 / Nrf2 / ARE redox-sensitive signaling system as a fundamental pathway that plays a key role in maintaining cellular redox homeostasis under stressful, inflammatory, carcinogenic and proapoptotic conditions. The structure of the cysteine-rich repressor protein Keap1, which is responsible for sensory perception of electrophiles and reactive oxygen species, the structure and functions of the transcription factor Nrf2, mechanisms of Nrf2 activation through the Keap1 / Nrf2 / ARE signaling system, which regulates the transcription and expression of cellular cytoprotective and antioxidant proteins, are described. Published data on the specificity of the interaction of the components of this cellular signaling pathway, the mechanisms of Keap1 dependent and independent adaptive response to the action of inductors, the role of biogenic selenium nanoparticles synthesized by green chemistry with the participation of bacteria in these processes are analyzed; features of Nrf2 induction depending on the type of bacteria and the stabilizing shell. It has been shown that biogenic selenium nanoparticles (BNSe), synthesized by different types of bacteria, activate the transcription factor Nrf2 using the Keap1-independent activation pathway through mitogen-protein kinases (MAPK): p38, ERK1 / 2 and AKT-mediated phosphorylation of Nrf2, protect the intestinal epithelial barrier function from the effects of oxidative damage, normalize mitochondrial function. A detailed understanding of thiol-dependent and independent redox signaling mechanisms under physiological and pathological conditions will lead to a deeper understanding of the redox component in human and animal diseases. The use of biogenic nanoselen, synthesized with the participation of various bacterial species, has been demonstrated to activate the Keap1 / Nrf2 / ARE signaling pathway, which may be of practical interest as a therapeutic target for many redox-mediated diseases.
Spontaneous Imbibition Investigation of Self-Dispersing Silica Nanofluids for Enhanced Oil Recovery in Low-Permeability Cores

A new kind of self-dispersing silica nanoparticle was prepared and used to enhance oil recovery in spontaneous imbibition tests of low-permeability cores. To avoid the aggregation of silica nanoparticles, a new kind of silica nanoparticle was prepared through the surface modification with vinyltriethoxysilane and 2-mercaptobenzimidazole as modified agents. Transmission electron microscopy, Fourier transform infrared spectroscopy, dynamic light scattering, and ζ potential measurements were employed to characterize the modified silica nanoparticles. Dispersing experiments indicated that modified silica nanoparticles had superior dispersity and stability in alkaline water. To evaluate the performance of silica nanofluids for enhanced oil recovery compared to pH 10 alkaline water and 5 wt % NaCl solution, spontaneous imbibition tests in sandstone cores were conducted. The results indicated that silica nanofluids can evidently improve oil recovery. To investigate the mechanism of nanoparticles for enhanced oil.
Risk Factors Similarity and Mergers and Acquisitions By :

In the M&A process, uncertainty impairs acquirers’ ability to assess targets’ intrinsic value as well as the expected synergy created from business combinations. Consistent with acquirers’ knowledge of potential downsides of targets’ business improving M&A quality, we document that the similarity between merging firms’ potential business downsides, measured with qualitative risk factor disclosures, is positively related to merger announcement returns, especially when acquirers face a greater level of uncertainty. We also find that downside risk similarity improves operating performance and reduces the likelihood of divestiture and incurring high restructuring costs in the post-merger period. Acquirers are more likely to pair with targets with more similar downside risks, more likely to complete deals with such targets, and pay less in equity in such deals, consistent with less uncertainty facilitating target selection and deal negotiation.
Five-factor model and internalizing and externalizing syndromes : 4 A 5-year prospective study

31 The main aim of the present research was to study the prospective relationships of the five-factor model 32 of personality and the internalizing and externalizing suprafactors of psychopathology. A sample of 323 33 young adults completed the NEO-FFI at Time 1 and different scales of symptoms 5 years later. Neuroti34 cism prospectively predicted the internalizing factor, while extraversion, low agreeableness and low con35 scientiousness predicted the externalizing factor. We found additional paths between introversion and 36 social phobia symptoms, and between low agreeableness and psychopathy symptoms. These relation37 ships remained significant, even when controlling for previous symptoms, except for extraversion. Gen38 der had no moderation effect on the interrelationship between personality and psychopathology factors. 39 The present study extends previous research about personality and psychopathology, and suggests differ40 ent ways in which they can be related. 41 ! 2015 Published by Elsevier Ltd. 42
The effect of debt covenant, political cost and IFRS implementation towards the company value

The research is aimed to analyze the influence of debt covenant, political cost and implementation of IFRS toward firm value. The population in this research are non public companies in the period 2016, 2017 and 2018. Non public companies are used as the population in this research to see the level of implementation of IFRS that have been applied by non public companies. The sample selection by using a random method and obtaining a sample of 46 companies or 138 observation data. The analysis used in this research is a Panel Data Regression by using Eviews 10.00. The partial result showed that political cost and implementation of IFRS affect firm value, while the debt covenant does not affect firm value. And the simultaneous result showed that debt covenant, political cost and implementation of IFRS affect firm value.
Cognition and Emotion ] Disillusionment : A Prototype Analysis

Disillusionment is acknowledged to be a painful process with important personal and social consequences. However, scientific conceptualisations of the experience are inconsistent. Across four studies, we examined whether lay conceptions of disillusionment produce a consistent pattern of features. In Study 1 (N = 204), we extracted 19 features of disillusionment from open-ended participant definitions. In Study 2 (N = 131), participants rated the centrality of these features and indicated that features such as discovery, disappointment, and loss, were highly representative, while features such as hopelessness, orientation, and truth, were more peripheral. In two further studies, we used experimental designs to test the diagnosticity of these features. In Study 3 (N = 155), participants rated vignettes descriptions as more disillusioning when they were based on more, rather than less, prototypical disillusionment features. Given that disappointment is a feature of disillusionment, we conducted Study 4 (N = 64) to test whether the extracted features effectively distinguish disillusionment from disappointment. Overall, we found evidence to suggest that disillusionment contains a consistent set of features, and represents a state of negative epistemic affect associated with the violation of core assumptions. These results create avenues for research on disillusionment, its antecedents and its consequences.
Causes , Consequences , and Cures of Clostridium difficile Infection

C. difficile infection (CDI) is distinctly associated with antibiotic use and the foremost cause of healthcare-associated infective diarrhea. The bacterial spores are primarily transmitted through the fecal-oral route. Worldwide, CDI affects about 8/100,000 individuals each year; the hospitalized population affected is about 4–8/1000 people), causing about 29,000 deaths in the United States alone; and affects about half a million people globally in 2011. In hospital settings, the spores are typically transmitted from the hands of healthcare workers to patients and vice versa. Risk factors for acquiring a C. difficile infection include exposure to most antibiotics, old age (although the younger population can be affected), and immunocompromised or hospitalized patients. The clinical presentation of CDI varies, from asymptomatic carriers to patients with life-threatening colitis. Patients with CDI may present with diarrhea, intense abdominal pain, fever, nausea, weakness, and decreased appetite or anorexia. Although active gastrointestinal bleeding is infrequent, fecal occult blood is positive in specific patients. The most severe form of CDI can lead to dehydration, abdominal distention, hypoalbuminemia, toxic megacolon, colon perforation, intestinal paralysis, kidney failure, septicemia, shock, and death. Most CDI cases are self-limiting with antibiotic therapy withdrawal or vancomycin/fidaxomicin/metronidazole therapy. However, in some patients, CDI can lead to complications requiring surgical intervention. In severe recurrent cases, fecal microbiota transplantation (FMT) is a promising treatment option. The preferred approach concerning CDI is contamination prevention rather than treating active CDI. Regular hand hygiene and other proactive sanitary measures are deemed simple yet effective measures in preventing C. difficile infection.
Primary Epiploic Appendagitis: A Case Report

Primary epiploic appendagitis (PEA) is a rather uncommon and self-limiting cause of acute abdomen managed conservatively. Overlapping clinical features with other common causes of acute abdomen usually requiring surgical intervention, and rare occurrences have led to misdiagnosis of the condition and unnecessary surgical intervention. However, with identification of definite characteristic features on imaging (computed tomography [CT] scan) has led to easier diagnosis and avoidance of exploratory laparotomy. Here we present a case of PEA in a 34-year-old otherwise healthy Caucasian male with a chief complaint of acute left-sided abdominal, flank and inguinal pain with diarrhea. Laboratory investigation reports were more or less within normal limits; CT scan confirmed the diagnosis of PEA. The patient was managed successfully with an oral antibiotic and a non-steroidal anti-inflammatory drug. CT scan should be done in cases of acute abdomen (if not absolutely contraindicated) for confirmation of diagnosis, as in our case CT scan helped in confirmation of diagnosis of PEA and thus avoided unnecessary surgical intervention. However, with the current advances in radiological tools, correct diagnosis of acute abdomen has become a lot easier, leading to timely surgical intervention and also at the same time avoidance of unnecessary exploratory laparotomy. Again, with documentation of specific characteristic radiological features of PEA, diagnosis of PEA has become much easier. After careful correlation among clinical, radiological, and laboratory findings, diagnosis of PEA was confirmed. The patient was managed conservatively at home with the advice of plenty of fluid intake and bed rest. Furthermore, he was prescribed an oral antibiotic (ciprofloxacin) and a non-steroidal anti-inflammatory drug (ibuprofen) empirically for seven days to prevent further complications like adhesions, bowel obstruction, intussusception, peritonitis, and local abscess formation. The patient recovered completely (the symptoms and signs resolved clinically) after one week. To conclude, it can be said, although rare in occurrence and lacking in specific presenting features, diagnosis of PEA has become easier with imaging techniques like CT scan and magnetic resonance imaging (MRI); thus, with prior awareness regarding this disease among physicians, unnecessary surgical interventions can be avoided.
Systematic review and meta-analysis of breast cancer brain metastasis and primary tumor receptor expression discordance

Abstract Background Change in hormone receptor (estrogen [ER] and progesterone [PR]) and/or human epidermal growth factor receptor type 2 (HER2) status during the evolutionary course of metastatic breast cancer and the effect of tumor classification subtype switching remain understudied and underappreciated in brain metastasis patients. Methods Using preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines, a systematic review of series published prior to April 2020 obtained from the Medline database of biopsied or resected breast cancer brain metastasis (BCBM) was performed. Weighted random effects models were used to calculate pooled estimates. Results 15 full-text articles were included with receptor expression analyses on 1373 patients who underwent biopsy or resection of at least one intracranial lesion to compare to the primary tumor. Primary tumor receptor expression immunophenotypes were 45.0% ER+, 41.0% ER−, 31.0% PR+, 51.0% PR−, 35% HER2+, and 47.0% HER2−. Corresponding BCBM immunophenotypes were 19.0% ER+, 31.0% ER−, 13.0% PR+, 40.0% PR−, 21.0% HER2+, and 26.0% HER2−. On primary/BCBM comparison, 540 patients (42.6%) exhibited discordance in any receptor with 17.0% (95% CI: 13.0%–23.0%) discordant on ER, 23.0% (95% CI: 18.0%–30.0%) discordant on PR, and 12.0% (95% CI: 8.0%–16.0%) discordant on HER2 status. The most common receptor conversions found in BCBM were ER loss 11.0% (95% CI: 8.0%–16.0%), PR loss 15.0% (95% CI: 11.0%–21.0%), and HER2 gain 9.0% (95% CI: 7.0%–11.0%). Conclusions BCBM exhibits significant receptor expression discordance in comparison to primary tumors in approximately 40% of patients. Classification patterns need to be analyzed to determine factors predictive of BCBM/primary tumor discordance. Overall, tumor subtype switching and its effect on clinical management remains underappreciated.
Why students do not turn on their video cameras during online classes and an equitable and inclusive plan to encourage them to do so

Abstract Enrollment in courses taught remotely in higher education has been on the rise, with a recent surge in response to a global pandemic. While adapting this form of teaching, instructors familiar with traditional face‐to‐face methods are now met with a new set of challenges, including students not turning on their cameras during synchronous class meetings held via videoconferencing. After transitioning to emergency remote instruction in response to the COVID‐19 pandemic, our introductory biology course shifted all in‐person laboratory sections into synchronous class meetings held via the Zoom videoconferencing program. Out of consideration for students, we established a policy that video camera use during class was optional, but encouraged. However, by the end of the semester, several of our instructors and students reported lower than desired camera use that diminished the educational experience. We surveyed students to better understand why they did not turn on their cameras. We confirmed several predicted reasons including the most frequently reported: being concerned about personal appearance. Other reasons included being concerned about other people and the physical location being seen in the background and having a weak internet connection, all of which our exploratory analyses suggest may disproportionately influence underrepresented minorities. Additionally, some students revealed to us that social norms also play a role in camera use. This information was used to develop strategies to encourage—without requiring—camera use while promoting equity and inclusion. Broadly, these strategies are to not require camera use, explicitly encourage usage while establishing norms, address potential distractions, engage students with active learning, and understand your students’ challenges through surveys. While the demographics and needs of students vary by course and institution, our recommendations will likely be directly helpful to many instructors and also serve as a model for gathering data to develop strategies more tailored for other student populations.
Intra-operative ocular ultrasonography of iodine-125 brachytherapy plaques in patients with uveal melanoma

Purpose Brachytherapy with iodine-125 (125I) has been extensively used as a conservative treatment for uveal melanoma (UM). Surgical technique for correct placement of episcleral radioactive plaques (ERP) in UM cases with posterior choroidal location and/or small size can be difficult and inaccurate. In this study, the correct positioning of plaques was assessed by intra-operative ultrasound control. Material and methods This was a longitudinal, retrospective study of consecutive 20 patients with UM (small-medium size and/or posterior location) who received 125I brachytherapy. Location of plaques was adjusted by intra-operative ocular ultrasonography control. To perform ocular intra-operative ultrasonography, a 10 MHz probe was used to longitudinal and transverse bases in corresponding dummy plaques. Results The study included 8 males and 12 females, with a mean age of 66.3 years (SD = 14.53), 5 right eyes (RE) and 15 left eyes (LE). In ultrasound examination, 4 UMs were of mushroom morphology and the rest nodular. Means of the size of UM by ultrasound were (mm): Lb: 10.60 (SD = 2.24) × Tb: 9.88 (SD = 1.54) × H: 4.02 (SD = 1.44) (3 cases corresponding to small size of collaborative ocular melanoma study (COMS), and 17 cases to medium). The plaques used were between 14 and 20 mm in diameter, with an average distance between the edge of greater base of the tumor and the edge of plate of 2.44 mm (SD = 0.34). It was necessary to surgically reposition the plaque in 4 cases (20%). Conclusions Intra-operative ultrasound control improves the accuracy of radioactive plaque placement for the treatment of medium-small UMs in posterior location. Probably, this technique should be applied in all cases of brachytherapy, regardless of the isotope chosen and the location of tumor mass, in order to perfectly adjust therapeutic position.
Two complete mitochondrial genomes of Papilio butterflies obtained from historical specimens (Lepidoptera: Papilionidae)

Abstract Museum specimens are collected for education, exhibition, and various multiple scientific purposes. However, millions of specimens remain in their collection boxes for years without being analyzed. Historical specimens have been known to contain low-quality DNA; hence, it is difficult to utilize their sequence information in phylogenetic studies. However, recent advances in high-throughput sequencing (HTS) make these collections amenable to phylogenomic studies. In this study, two historical specimens (Papilio xuthus Linnaeus, 1767, and Papilio thoas Linnaeus, 1771) were sampled and DNA extracted for HTS via the Miseq platform. Two complete mitogenomes were assembled, even though the DNA quality of those specimens was highly fragmented, below 250 bp in length. The 37 genes of 60 mitogenomes were aligned and used for inferring the phylogenetic relationships of Papilioninae. These two newly sequenced mitogenomes are correctly grouped in the genus Papilio, and this result indicates that historical specimens show great potential for phylogenetic studies with HTS technology.