Miracle-dz/UniFAR-FTUs huggingface dataset:
MEMS-based microheaters integrated gas sensors

Abstract In the present work efforts have been made to develop microheater integrated gas sensors with low power consumption. The design and simulation of a single-cell microheater is carried out using ANSYS. Low power consumption (<35 mW) platinum micro-heater has been fabricated using bulk micromachining technique on silicon dioxide membrane (1.5 μm thin), which provided improved thermal isolation of the active area of 250 × 250 μm2. The micro-heater has achieved a maximum temperature of ∼950 °C at an applied dc voltage of 2.5 V. Fabricated mircro-heater has been integrated with SnO2 based gas sensors for the efficient detection of H2 and NO2 gases. The developed sensors were found to yield the maximum sensing response of ∼184 and ∼2.1 with low power consumption of 29.18 and 34.53 mW towards the detection of 1 ppm of NO2 gas and 500 ppm of H2 gas, respectively.
Hubungan Budaya Organisasi dengan Penerapan keselamatan Pasien Oleh Perawat di RSUD dr Rasidin Padang Tahun 2015

Keselamatan pasien menjadi isu prioritas dalam perawatan kesehatan dan merupakan komponen penting dari mutu layanan kesehatan. Budaya organisasi merupakan salah satu faktor dalam penerapan keselamatan pasien. Berdasarkan pengamatan di RSUD dr Rasidin Padang ditemukan bahwa penerapan keselamatan pasien oleh perawat belum optimal. Tujuan penelitian ini adalah untuk mengetahui hubungan budaya organisasi dengan penerapan keselamatan pasien oleh perawat di ruang rawat RSUD drRasidin Padang. Jenis penelitian ini bersifat analitik dengan menggunakan metode pendekatan cross sectional study. Populasi penelitian ini adalah perawat di RSUD dr Rasidin Padang yang berjumlah 45 perawat. Teknik pengambilan sampel purposive sampling sebanyak 42 perawat. Pengumpulan data dilakukan menggunakan kuesionerdan lembar observasi. Penelitian menunjukkan lebih dari separuh (54,8%) perawat menerapkan keselamatan pasien kurang baik dan lebih dari separuh (52,4%) perawat mempersepsikan budayaorganisasikurangbaik. Hasil analisis dengan chi-square menunjukkan bahwa terdapat hubungan yang bermakna antara budaya organisasi dengan penerapan keselamatan pasien (p value = 0,032). Diharapkan agarperawatdapatmeningkatkankeselamatanpasienterutamadalamhalmengidentifikasipasiendandalamhalpenguranganresikoinfeksi. Bagi instansi dapat meningkatkan budaya organisasi dengan cara surat keputusan tentang uraian tugas bagi perawat, meningkatkan lingkungan fisik yang mengacu pada keselamatan pasien.
A Bioactive Diterpene from Entada Abyssinica

Three clerodane diterpenoids, 8S-kolavic acid 18-methyl ester (1), 8S-kolavic acid 15-methyl ester (2) and 8S-kolavenol (3) were isolated from the acetone extract of the stem bark of Entada abyssinica along with trans-communic acid (4) and 1-octacosanol. Their structures were established mainly based on 1D (1H, 13C and DEPT) and 2D (1H-1H COSY, HSQC and HMBC) NMR experiments. Compound 1, described here for the first time, showed strong antimicrobial and moderate antileishmanial activities.
Subnational Diversity in Sub-Saharan Africa: Insights from a New Dataset

This paper presents a new dataset on subnational ethnolinguistic diversity in Sub-Saharan Africa covering 36 countries and almost 400 first-level administrative units. We compile detailed data on the ethnolinguistic composition of each region using population censuses and large-scale household surveys and match all reported ethnicities to Ethnologue, the most complete classifier of world languages. This matching allows to standardize the notion of an ethnolinguistic group and account for the relatedness between language pairs when calculating diversity indices. We exploit this high-quality dataset to investigate the connection between diversity, as captured by fractionalization and polarization indices, and development indicators at the subnational level. Educational and health outcomes, electricity access, and nighttime luminosity are all negatively related to diversity, even after controlling for country fixed effects and a rich set of regional characteristics, but only if the underlying ethnolinguistic groups are sufficiently aggregated into more basic language families or if linguistic similarities between them are taken into account. In other words, only deep-rooted diversity based on cleavages formed in the distant past is strongly inversely associated with regional development. Furthermore, we show that subnational diversity is remarkably persistent over time implying that reverse causality is unlikely to bias our main findings.
Enhancing Primary School Students’ Analogical Reasoning in Solving Open-ended Word Problems

This study aims to identify primary school students' analogical reasoning in solving open-ended word problems. This is qualitative research with a case study approach. The participants in this study were 25 fifth-grade primary school students selected using the purposive sampling technique to represent each category of analogical reasoning based on analogical reasoning tasks. Research instruments comprised of tests in analogical reasoning tasks and interview guidelines. Data analysis techniques included data reduction, presentation
A review of the systematic position of the dinosauriform archosaur Eucoelophysis baldwini sullivan & lucas, 1999 from the upper triassic of New Mexico, USA

Eucoelophysis batdwini Sullivan & Lucas, 1999 is represented by several postcranial elements from the Petrified Forest Formation (Norian), New Mexico, USA. Eucoelophysis Sullivan & Lucas, 1999 was widely considered as a coelophysoid dinosaur by several authors, but the hindlimb anatomy of this genus clearly indicates that it belongs to neither of these groups. The following features exclude Eucoelophysis from Neotheropoda: absence of oblique ligament groove on caudal surface of femoral head, femoral medial epicondyle small and smoothly rounded, absence of caudal cleft between medial part of the proximal end of the tibia and fibular condyles, cnemial crest low, and fibular crest absent. Moreover, Eucoelophysis lacks dinosaurian synapomorphic characters, but has a plesiomorphic slightly inturned femoral head that prevents its assignment to Dinosauria. Interestingly, the morphology of the femur of Eucoelophysis is extremely similar to that of the basal dinosauriform Silesaurus opolensis Dzik, 2003 from the Late Triassic of Poland. In order to determine the phylogenetic position of Eucoelophysis, a cladistic analysis was carried out, which depicts Eucoelophysis as a non-dinosaurian dinosauriform. Thus reinterpreted, Eucoelophysis constitutes the youngest record of a non-dinosaurian dinosauriform, indicating their survival into the Norian, being co-eval with early dinosaurs.
Dangerous Interference with the Climate System: An Economic Assessment

This paper combines uncertainty about the impact of climate change on human welfare with the distribution of impacts over space and time. The best guess of world average impacts shows a relatively small impact, but with an uncertainty is large and skewed towards negative surprises. Poorer countries are more vulnerable to climate change. There is a 1% chance of a total loss in some countries at warming above 3°C. Generally, economic growth would reduce vulnerability, but this may not be true for the tail of the distribution for warming above 3°C. Thus, 3°C global warming appears as a critical threshold above which climate change is dangerous.
Identification of a β-Carboline Alkaloid from Chemoselectively Derived Vanilla Bean Extract and Its Prevention of Lipid Droplet Accumulation in Human Hepatocytes (HepG2)

Targeting bioactive compounds to prevent lipid droplet accumulation in the liver, we explored an antioxidative extract from vanilla bean (Vainilla planifolia) after chemo-selective derivatization through heating and acid modification. The chemical analysis of vanilla bean extract through chemoselective derivatization resulted in the identification of sixteen compounds (34–50) using LC-MS/MS analysis. A β-carboline alkaloid with a piperidine C-ring and a vanillin moiety at C-1 (34) was identified by molecular networking and diagnostic fragmentation filtering approaches. β-carboline alkaloid 34 exhibited significant inhibitory activity of lipid droplet accumulation (LDAI) in oleic acid-loaded hepatocellular carcinoma HepG2 cells. The LDAI activity was associated with both activation of lipolysis and suppression of lipogenesis in the cells. The study indicates that crude plant extracts, following chemoselective derivatization, may contain bioactive compounds that could be beneficial in preventing hepatosteatosis and could serve as a source of lead compounds for drug development. This approach may be useful to investigate other mixtures of natural products and food resources.
KLF17 is an important regulatory component of the transcriptomic response of Atlantic salmon macrophages to Piscirickettsia salmonis infection

Piscirickettsia salmonis is the most important health problem facing Chilean Aquaculture. Previous reports suggest that P. salmonis can survive in salmonid macrophages by interfering with the host immune response. However, the relevant aspects of the molecular pathogenesis of P. salmonis have been poorly characterized. In this work, we evaluated the transcriptomic changes in macrophage-like cell line SHK-1 infected with P. salmonis at 24- and 48-hours post-infection (hpi) and generated network models of the macrophage response to the infection using co-expression analysis and regulatory transcription factor-target gene information. Transcriptomic analysis showed that 635 genes were differentially expressed after 24- and/or 48-hpi. The pattern of expression of these genes was analyzed by weighted co-expression network analysis (WGCNA), which classified genes into 4 modules of expression, comprising early responses to the bacterium. Induced genes included genes involved in metabolism and cell differentiation, intracellular transportation, and cytoskeleton reorganization, while repressed genes included genes involved in extracellular matrix organization and RNA metabolism. To understand how these expression changes are orchestrated and to pinpoint relevant transcription factors (TFs) controlling the response, we established a curated database of TF-target gene regulatory interactions in Salmo salar, SalSaDB. Using this resource, together with co-expression module data, we generated infection context-specific networks that were analyzed to determine highly connected TF nodes. We found that the most connected TF of the 24- and 48-hpi response networks is KLF17, an ortholog of the KLF4 TF involved in the polarization of macrophages to an M2-phenotype in mammals. Interestingly, while KLF17 is induced by P. salmonis infection, other TFs, such as NOTCH3 and NFATC1, whose orthologs in mammals are related to M1-like macrophages, are repressed. In sum, our results suggest the induction of early regulatory events associated with an M2-like phenotype of macrophages that drives effectors related to the lysosome, RNA metabolism, cytoskeleton organization, and extracellular matrix remodeling. Moreover, the M1-like response seems delayed in generating an effective response, suggesting a polarization towards M2-like macrophages that allows the survival of P. salmonis. This work also contributes to SalSaDB, a curated database of TF-target gene interactions that is freely available for the Atlantic salmon community.
Preparation of 18F-Labeled Tracers Targeting Fibroblast Activation Protein via Sulfur [18F]Fluoride Exchange Reaction

Early detection and treatment of cancers can significantly increase patient prognosis and enhance the quality of life of affected patients. The emerging significance of the tumor microenvironment (TME) as a new frontier for cancer diagnosis and therapy may be exploited by radiolabeled tracers for diagnostic imaging techniques such as positron emission tomography (PET). Cancer-associated fibroblasts (CAFs) within the TME are identified by biomarkers such as fibroblast activation protein alpha (FAPα), which are expressed on their surfaces. Targeting FAPα using small-molecule 18F-labeled inhibitors (FAPIs) has recently garnered significant attention for non-invasive tumor visualization using PET. Herein, two potent aryl-fluorosulfate-based FAPIs, 12 and 13, were synthetically prepared, and their inhibition potency was determined using a fluorimetric FAP assay to be IC50 9.63 and 4.17 nM, respectively. Radiofluorination was performed via the sulfur [18F]fluoride exchange ([18F]SuFEx) reaction to furnish [18F]12 and [18F]13 in high activity yields (AY) of 39–56% and molar activities (Am) between 20–55 GBq/µmol. In vitro experiments focused on the stability of the radiolabeled FAPIs after incubation with human serum, liver microsomes and liver cytosol. Preliminary PET studies of the radioligands were performed in healthy mice to investigate the in vivo biodistribution and 18F defluorination rate. Fast pharmacokinetics for the FAP-targeting tracers were retained and considerable bone uptake, caused by either 18F defluorination or radioligand accumulation, was observed. In summary, our findings demonstrate the efficiency of [18F]SuFEx as a radiolabeling method as well as its advantages and limitations with respect to PET tracer development.
Characterising deep vadose zone water movement and solute transport under typical irrigated cropland in the North China Plain

Understanding the dynamics and mechanisms of soil water movement and solute transport is essential for accurately estimating recharge rates and evaluating the impacts of agricultural activities on groundwater resources. In a thick vadose zone (0–15 m) under irrigated cropland in the piedmont region of the North China Plain, soil water content, matric potential, and solute concentrations were measured. Based on these data, the dynamics of soil water and solutes were analysed to investigate the mechanisms of soil water and solute transport. The study showed that the 0–15‐m vadose zone can be divided into three layers: an infiltration and evaporation layer (0–2 m), an unsteady infiltration layer (2–6 m), and a quasi‐steady infiltration layer (6–15 m). The chloride, nitrate, and sulphate concentrations all showed greater variations in the upper soil layer (0–1 m) compared to values in the deep vadose zone (below 2 m). The average concentrations of these three anions in the deep vadose zone varied insignificantly with depth and approached values of 125, 242, and 116 mg/L. The accumulated chloride, sulphate, and nitrate were 2,179 ± 113, 1,760 ± 383, and 4,074 ± 421 kg/ha, respectively. The soil water potential and solute concentrations indicated that uniform flow and preferential flow both occurred in the deep vadose zone, and uniform flow was the dominant mechanism of soil water movement in this study. The piston‐like flow velocity of solute transport was 1.14 m per year, and the average value of calculated leached nitrate nitrogen was 107 kg/ha∙year below the root zone. The results can be used to better understand recharge processes and improve groundwater resources management.
Density and P‐wave velocity structure beneath the Paraná Magmatic Province: Refertilization of an ancient lithospheric mantle

We estimate density and P‐wave velocity perturbations in the mantle beneath the southeastern South America plate from geoid anomalies and P‐wave traveltime residuals to constrain the structure of the lithosphere underneath the Paraná Magmatic Province (PMP) and conterminous geological provinces. Our analysis shows a consistent correlation between density and velocity anomalies. The P‐wave speed and density are 1% and 15 kg/m3 lower, respectively, in the upper mantle under the Late Cretaceous to Cenozoic alkaline provinces, except beneath the Goiás Alkaline Province (GAP), where density (+20 kg/m3) and velocity (+0.5%) are relatively high. Underneath the PMP, the density is higher by about 50 kg/m3 in the north and 25 kg/m3 in the south, to a depth of 250 − 300 km. These values correlate with high‐velocity perturbations of +0.5% and +0.3%, respectively. Profiles of density perturbation versus depth in the upper mantle are different for the PMP and the adjacent Archean São Francisco (SFC) and Amazonian (AC) cratons. The Paleoproterozoic PMP basement has a high‐density root. The density is relatively low in the SFC and AC lithospheres. A reduction of density is a typical characteristic of chemically depleted Archean cratons. A more fertile Proterozoic and Phanerozoic subcontinental lithospheric mantle has a higher density, as deduced from density estimates of mantle xenoliths of different ages and composition. In conjunction with Re‐Os isotopic studies of the PMP basalts, chemical and isotopic analyses of peridodite xenoliths from the GAP in the northern PMP, and electromagnetic induction experiments of the PMP lithosphere, our density and P‐wave speed models suggest that the densification of the PMP lithosphere and flood basalt generation are related to mantle refertilization. Metasomatic refertilization resulted from the introduction of asthenospheric components from the mantle wedge above Proterozoic subduction zones, which surrounded the Paraná lithosphere. The high‐density PMP lithosphere is presently gravitationally unstable and prone to delamination.
Induction of Synthetic Polyploids of Porang (Amorphophallus muelerri Blume) and Assessment of Its Genetic Variability Using Morphological Data and RAPD Molecular Marker

This study uses morphological characteristics and RAPD markers to evaluate the polyploidization of synthetic porang. Seeds of triploid porang (2n=2x=26) were soaked in the different colchicine concentrations for 24 hours. After colchicine treatment, the porang seeds were planted to an MS medium that contained 2.2 µM of 6-benzylaminopurine (BAP), then, 40 days after planting in the MS media, the morphology and molecular of synthetic polyploid porang were characterized. For DNA extraction, a total of 100 mg of young leaves of porang plantlet was collected. One way Anova followed by the Duncan test (95%) was performed for phenotypic characterization. The number of different alleles, number of effective alleles, Shannon's information index, diversity, and unbiased diversity were assessed for genetic diversity. Synthetic polyploid porang has a higher total shoot, root, and wider leaves than normal porang. Polyploidy induction also successfully increased the genetic diversity of porang, and the genetic diversity will increase porang adaptability and sustainability of porang cultivation.
"Story Time!": Coping with Low-Motivated Students using Big Book

Background: Reading the picture book provides students with numerous positive effects, especially young students, such as attracting students' interest, boosting creativity, providing a pleasant, relaxed vibe, and creating fun and meaningful learning. This research seeks to investigate whether the reading comprehension of low-motivated students who are taught with the big book or with the daily storybook varies significantly. Methodology: This study used quasi-experiments, and each group received treatment eight times. The participants were 44 students recruited to become the sample of this study, consisting of experiment and control groups. Findings: This study revealed that students with low motivation who taught with Big Book as a platform are better than students with low motivation taught on traditional media. Several factors have made a big book an instrument that has a more significant impact on students' perception of reading than conventional media. Secondly, students engaged more in-class reading than in conventional media. Thirdly, the book sparked the interest of students and inspired them to learn more. Fourthly, the Big Book helped students create the meaning of the text and appreciate the text more thoroughly. Conclusion: English oral books such as Big-Book are more effective than traditional content in the second year. This study and published data support this conclusion that using large books as a tool for second years' reading understanding affects students' understanding of lectures significantly. The statistical study has found that the total student readership in the test group is higher than the average student score in the control group. Keywords: reading comprehension; low motivation; pupils; picture book.
Evidence for the evolutionary history and diversity of fossil sweetgums: leaves and associated capitate reproductive structures of Liquidambar from the Eocene of Hainan Island, South China

Extant species of Liquidambar L. exhibit a disjunct distribution between western and eastern Asia and eastern North America to Central America, with the highest species diversity being in China. In this study, two new species of Liquidambar are described from the Eocene of Hainan Island, South China: L. hainanensis on basis of the leaf fossils, and L. ovoidea based on compressions of infructescences. The co‐occurrences of L. hainanensis leaves, associated infructescences of L. ovoidea and dispersed pantoporate pollen grains have the combination of morphological features peculiar to the genera Liquidambar and former Semiliquidambar and Altingia. This is considered further palaeobotanical justification for the placement of these three genera into a single genus, Liquidambar, proposed earlier based on molecular markers. Our data provide evidence for the occurrence of an ancestral polymorphic group of Liquidambar species (L. maomingensis with associated capitate infructescences, L. bella, L. hainanensis and L. ovoidea) during the Eocene in South China, and corroborate the view that South China could have been a centre of Liquidambar speciation during the Eocene. The morphological similarity of L. hainanensis leaves to those of the extant species L. orientalis from Western Asia and the North American L. styraciflua may support the importance of both the North Atlantic Land Bridge and the Bering Land Bridge for the dispersal of Liquidambar. Analysis of fossil species of Liquidambar from eastern Asia also contributes to further understanding of patterns in the taxonomic diversity and evolutionary history of this genus.
The Seattle Heart Failure Model in Kidney Transplant Recipients

Cardiovascular disease is the leading cause of mortality following kidney transplantation. Heart failure affects 17–21% of patients with chronic kidney disease and increases along with time receiving dialysis. The Seattle Heart Failure Model (SHFM) is a validated mortality risk model for heart failure patients that incorporates clinical, therapeutic, and laboratory parameters but does not include measures of kidney function. We applied the SHFM to patients with end-stage renal disease (ESRD) who were being evaluated for kidney transplantation to determine if the model was associated with post-transplant mortality. This retrospective single-center study analyzed survival among 360 adult deceased-donor kidney transplant recipients. Cox regression was used to model post-transplant patient survival. Our findings indicated that a 1.0-point increase in the adapted SHFM score was significantly associated with post-transplant mortality (HR 1.76, 95% CI = 1.10–2.83, p = 0.02), independently of the Kidney Donor Profile Index and Estimated Post-Transplant Survival. Individual covariates of the SHFM were evaluated in univariate analyses, and age, sodium, cholesterol, and lymphocyte count were significantly related to mortality. This study provides preliminary evidence that an adapted SHFM score could be a useful tool in evaluating mortality risk post-transplant in patients with ESRD.