Miracle-dz/UniFAR-FTUs huggingface dataset:
The Future Perspectives of Redefining the Resection Margin Status in Different Cancers of Pancreas

Background: The interest towards the assessment of circumferential resection margins(CRM) in pancreatic cancers has been evolving over last years. Whilst several studies investigated the influence of R1-resections on survival, not many studies evaluated the prognostic value of each resection margin. In this study, we examined the different resection margins to better understand their prognostic implications on overall survival. Methods: This prospective study included a cohort of patients who had pancreaticoduodenectomy for cancer purposes at our institution from 2008 till 2013. Median follow-up was 6 years. Involved margins in R1-resections were further classified into anatomical margins (anterior, posterior and circumferential margins) and surgical margins (vascular/medial margins and transection margins). Overall survival was assessed for each specific resection margin. Results: 134 patients were included with median age 66 years. R1-resection was done in 54% of patients(n=72/134). Median survival of R0-resection group was 6.3 years, compared to 1.9 years for R1-resection group(p-value 0.001). Vascular (surgical) margins had the lowest survival rate (1.7years) compared to anatomical margins (anterior, posterior and circumferential margins) with 3.6, 2.2 and 2.1 years respectively (p-value 0.02). On multivariate analysis; lymph node involvement and vascular resection were the only factors to correlate significantly with poor survival. Conclusion: Whilst the new pathological protocols advised to perform rigorous margin assessment of CRM, the prognostic value of each resection margin is still unclear. This study showed variation of survival across different resection margins with inferiority towards vascular (surgical) margins. This supported the need of redefining R1-margins in the future pathological classifications according to their different prognostic impacts.
Quantitative analysis of loss of anesthesia management opportunities and procedural skills due to COVID-19 pandemic lockdown: An experience of six months from a tertiary care cancer teaching institute

Background and Aims: COVID-19 has necessitated restrictions on elective surgical workload, which could adversely affect the learning of the core clinical competencies of the postgraduate anesthesiology trainees. The aim was to assess and compare the loss of elective cases requiring anesthesia management and associated procedural skills in six months since lockdown compared to the same duration in 2019. Material and Methods: We compared the data, obtained from electronic medical records, of the total number of elective surgeries requiring anesthesia management and the following procedural skills in both adults and pediatric patients in 6 months duration in 2019 and 2020: 1) Laryngoscopy and Intubation 2) Laryngeal mask airway 3) Arterial and central line cannulations and 4) Spinal, Epidural, Other Regional blocks. Results: A total of 8458 and 3561 elective procedures were performed in the six-month period in 2019 and 2020 respectively, reflecting a 57.9% reduction due to lockdown. There was a proportionate reduction in the adult and pediatric procedures, operating room and non-operating room procedures, and surgeries performed under general anesthesia and monitored anesthesia care. There was a significant increase in the number of surgeries performed under regional anesthesia (486%). Epidurals blocks and other regional blocks also showed a proportionate reduction respectively. Although the total number of video-laryngoscopy assisted intubations show an absolute reduction, when compared to the total number of cases performed in the respective years, we found an increase (2.06% in 2019 vs 3.8% in 2020). The arterial cannulations reduced by 43.29% but the central line cannulations reduced by only 12.28%. Conclusion: There was a significant reduction in both the anesthesia management opportunities and in the total number of associated procedural skills due to COVID-19 lockdown which could adversely affect the learning of core clinical competencies of postgraduate trainees.
Work-from-home adjustment in the US and Europe: the role of psychological climate for face time and perceived availability expectations

Abstract The COVID-19 pandemic has precipitated a massive adoption of high-intensity work-from-home (WFH), a form of work organization that is expected to persist. Yet, little is known about the predictors and mechanisms underlying employees’ successful adjustment to high-intensity WFH. Drawing on signaling theory, we identify psychological climate for face time (i.e., an employee’s perception that their organization values physical presence in the office) as an antecedent of WFH adjustment. We argue that when WFH employees perceive that their organization encourages face time, they may view availability as a signal of their dedication to work, replacing visibility. Consequently, they feel expected to be extensively available (e.g., check emails outside of regular working hours). In turn, these perceived expectations predict lower adjustment to WFH. We further explore whether this process differs in the US and two European countries, France and Spain, given different employment protection and right to disconnect legislations, and different meanings attached to work ethics. In a two-wave study on a sample of 532 full-time WFH employees, structural equation modeling analyses show that perceptions of availability expectations mediate the negative relationship between psychological climate for face time and WFH adjustment, and that this process is accentuated in the US.
The normal electrocardiographic studies in healthy Assam hill goats

The aim of this study was to determine the normal electrocardiographic (ECG) values for standard lead II in Assam hill goats. The mean heart rate in the goats studied was 103.65±4.91 beat per minute and ranged between 90 and 130 bpm. The P voltage in lead II was oriented in the positive direction. No negative P wave was found. The lead II P wave amplitude was 0.1 mV±0.009 and P wave duration was 0.03s±0.001. The T wave amplitude and duration were 0.13mV±0.010 and 0.04s±0.001. The QRS complex amplitude and duration were 0.32mV±0.02 and 0.04s±0.001. The duration of PR interval, ST interval and QT in lead II recorded are 0.07±0.003, 0.14s±0.003 and 0.22s±0.001 respectively.
Transplantation of the Horseshoe Kidneys: A Model for Dual Adult Kidney Transplantation

Background: The shortage of organs has called for the use of two marginal adult kidneys (MAKs) with a low nephron mass as dual adult kidneys transplanted to a single recipient. The operative techniques of the transplantation of these kidneys are still debated. Since the horseshoe kidneys have been transplanted as early as 1975, it is theorized that the technique of the en bloc transplantation of the horseshoe kidney may be applied to the MAKs. Material and Methods: The world literature search during the period 1975–2021 on the use of deceased-donor horseshoe kidneys was reviewed. The selection of the donors, the anatomy of the kidneys, the principles of organ recovery, the transplantation procedure, and the results were discussed. Finally, this technique of en bloc transplantation was applied successfully to seven pairs of MAKs and is described herein. The dual adult kidneys were simultaneously vascularized by the donor aorta and vena cava, which were anastomosed, respectively, to the recipient iliac artery and vein. Results: A total of 131 case reports of deceased horseshoe kidney donors were reviewed, of which 53 en bloc kidneys were transplanted successfully to a single recipient, and the remaining 78 were divided and transplanted as single units to 131 recipients. Twenty-five single kidneys were discarded. At the time of publication, all horseshoe kidneys had a good renal function. In the series of seven pairs of MAKs transplanted en bloc, the operative time was 3 h. There were no primary nonfunctions, no vascular thromboses, no urinary leakages, and no wound infections. Only two patients required temporary dialysis despite an average of 28.4 h of cold ischemia time. No hydronephrosis and lymphocele was experienced. Both patient and graft survival were 100%. At the time of follow-up at 36 months, serum creatinine levels averaged 1.8 mg/dL (range 1.4–1.9). Conclusions: This technique of en bloc renal transplantation using the donor aorta and vena cava for revascularization can be applied to both the horseshoe kidneys and the MAK, and improve organ utilization.
Intimate partner violence incidents reporting by female minorities in the United States

Abstract The study assessed differences in intimate partner violence (IPV) incident reporting to police by minority and non-minority IPV survivors. Data originated from U.S. Census Bureau’s National Crime Victimization Survey from 2010 to 2020. Of 240,000 interviews, 2,255 female respondents (750 female minorities) answered questions regarding violence perpetrated by a current/former intimate partner. Female minorities were less likely to report their IPV incident than non-Hispanic White females. Non-Hispanic Blacks were more likely to report their IPV incident to the police than Hispanics when the incident was near home. Disparities in reporting may obstruct efforts to protect the rights of the accused and victims. Findings help victim services providers ensure victims are provided support, resources, and care to overcome reporting barriers of IPV.
Skillful Long‐Lead Prediction of Summertime Heavy Rainfall in the US Midwest From Sea Surface Salinity

Summertime heavy rainfall and its resultant floods are among the most harmful natural hazards in the US Midwest, one of the world's primary crop production areas. However, seasonal forecasts of heavy rain, currently based on preseason sea surface temperature anomalies (SSTAs), remain unsatisfactory. Here, we present evidence that sea surface salinity anomalies (SSSAs) over the tropical western Pacific and subtropical North Atlantic are skillful predictors of summer time heavy rainfall one season ahead. A one standard deviation change in tropical western Pacific SSSA is associated with a 1.8 mm day−1 increase in local precipitation, which excites a teleconnection pattern to extratropical North Pacific. Via extratropical air‐sea interaction and long memory of midlatitude SSTA, a wave train favorable for US Midwest heavy rain is induced. Combined with soil moisture feedbacks bridging the springtime North Atlantic salinity, the SSSA‐based statistical prediction model improves Midwest heavy rainfall forecasts by 92%, complementing existing SSTA‐based frameworks.
Bearing Fault Diagnosis Based on Multi-scale Neural Networks

In this paper, a framework using multi-scale neural networks for bearing fault diagnosis is proposed. This framework consists of two stages. The first stage decomposes raw bearing signal into multiple multi-scale signals by signal decomposition and transform. The second stage applies the multi-scale signals to the corresponding input channels designated for the multi-scale neural network and concatenates outputs of all parallel sub-neural networks into a single channel which is further used as the input to a fully connected layer for classification. In comparison with the other bearing fault diagnosis methods, our proposed method can achieve high classification accuracy of 98.7% using one-dimensional convolutional neural networks (1D-CNN) with less computation based on Case Western Reserve University Dataset (CWRU).
Preparing undergraduate students for career success through case study writing and implementation in real job contexts

The objective of this study was to test the effectiveness of a procedure to train undergraduate students to write and implement case studies for improving their learning experiences, adapt to the labor environment and be better prepared for career success. Method . Undergraduate students in social service internships at the Higher State Auditing Office in the states of Yucatan, Campeche and Q. Roo, in the Southeast of Mexico, under the guidance of Government Auditors, designed case studies to be implemented with their classmates following the procedure studied in this document, prepared by the author of this research. Results. Results showed that after this experience, implementer students were more motivated for learning, more interested in case studies, more confident at working with others and were satisfied with learning. This was compared to the learning through traditional methods, according to their perception. Conclusion. This case study procedure is effective for preparing students for improving their technical and socio-emotional competencies in their preparation for career success, but also a professional development opportunity for the Auditors. Learning to write and implement cases help learning and adaptation to work environment. It is learning how to learn and be prepared for career success through experiences such as this in real job contexts.
THE EFFECT OF MODERATING CREDIT RISK ON THE INFLUENCE OF FIRM SIZE, LIQUIDITY, AND OPERATIONAL EFFICIENCY ON THE FINANCIAL PERFORMANCE OF REGIONAL DEVELOPMENT BANKS OF INDONESIA 2010- 2020

This study examines the credit risk moderating effect on the effect of firm size, liquidity, and operational efficiency on the financial performance of Regional Development Banks (BPDs) in Indonesia from 2010 to 2020. The population was BPDs in Indonesia. The sample was taken using the purposive sampling method, provides 18 banks. Data were analyzed through the panel data regression using the Eviews 12 application and MRA (Moderate Regression Analysis) tests. The results of hypothesis testing show that firm Size and LDR positively impact ROA, while Operational Efficiency has a negative impact, and NPL cannot moderate the impact of company size on ROA but can moderate the effect of LDR and Operational Efficiency on ROA. From these findings, it reveals that the model of increasing ROA at BPD in Indonesia is a function of increasing firm size and LDR and decreasing Operational Efficiency whereas NPL can strengthen the role of LDR and weaken the role of Operational Efficiency.
A Sensor Network Utilizing Consumer Wearables for Telerehabilitation of Post-Acute COVID-19 Patients

A considerable number of patients with COVID-19 suffer from respiratory problems in the post-acute phase of the disease (the second–third month after disease onset). Individual telerehabilitation and telecoaching are viable, effective options for treating these patients. To treat patients individually, medical staff must have detailed knowledge of their physical activity and condition. A sensor network that utilizes medical-grade devices can be created to collect these data, but the price and availability of these devices might limit such a network’s scalability to larger groups of patients. Hence, the use of low-cost commercial fitness wearables is an option worth exploring. This article presents the concept and technical infrastructure of such a telerehabilitation program that started in April 2021 in the Czech Republic. A pilot controlled study with 14 patients with COVID-19 indicated the program’s potential to improve patients’ physical activity, (85.7% of patients in telerehabilitation versus 41.9% educational group) and exercise tolerance (71.4% of patients in telerehabilitation versus 42.8% of the educational group). Regarding the accuracy of collected data, the used commercial wristband was compared with the medical-grade device in a separate test. Evaluating $z$ -scores of the intensity of participants’ physical activity in this test, the difference in data is not statistically significant at level $p=0.05$ . Hence, the used infrastructure can be considered sufficiently accurate for the telerehabilitation program examined in this study. The technical and medical aspects of the problem are discussed, as well as the technical details of the solution and the lessons learned, regarding using this approach to treat COVID-19 patients in the post-acute phase.
A Micromodeling Approach To Investigate The Advertising-Sales Relationship

AbstractThe purpose of this paper is to derive a model of advertising effects on the firm's sales. A micromodel is postulated and aggregated across individuals and over time to produce a macromodel of the aggregate sales-advertising relationship for a single product. The micromodel postulated is very simple. It incorporates two factors: reach of the ads and rate of decay of their effectiveness over time.This approach to modeling advertising effects is shown to be fruitful in several respects: (1) the coefficients of the aggregate equation are easily interpretable—in terms of the reach and decay parameters; (2) the model derived is nonlinear yet estimable; (3) a special case of the model is very similar to lag models that have been in use; (4) the model can be used whatever the unit of time is; (5) the carryover effect of advertising (as commonly defined) is not constant, but depends upon the previous spending levels; and (6) the model helps illustrate that the duration of advertising may be greatly overstated if aggregate lagged dependent variable models are simplistically interpreted.
Contribution of Brain Cortical Features to the Psychological Risk Profile of Juvenile Offenders

Objectives: This study contributes to the neuroscience of offending behavior by addressing two aims: a) to examine differences in the cortical features in a group of male serious juvenile offenders (21 OG), versus controls (28 CG), both ranging from 18 to 21 years old; and b) to determine to what extent the differential cortical features and the risk psychological profile discriminate between the two groups. Method: Besides cortical measures, demographics, executive functioning, childhood trauma, psychopathic traits, psychopathological symptoms, and antisocial and delinquent behavior were assessed. Results: Whole-brain analysis of the cortical mantle identified increased cortical thickness in the cluster comprising the right middle temporal gyrus and a smaller surface area in the lateral orbitofrontal cortex for the OG compared to the CG. The discriminant function correctly classified 100% of cases of the CG and 94.7% of the OG. Right temporal cluster, childhood trauma, callousness and symptoms of interpersonal sensitivity, psychoticism, depression, phobic anxiety, and obsessive-compulsive behavior contributed to the OG. In turn, the lateral orbitofrontal cluster, psychopathic traits of grandiosity, unemotionality, and thrill seeking, and working memory contributed to the CG. Conclusions: The increased right middle temporal gyrus of the OG could be indicative of impaired brain development in social cognition processes since it appeared in combination with the higher risk profile. The reduced orbitofrontal cortex could be indicative of immature brain development in emotional control processes since it appeared in combination with the normative psychological profile in adolescence. Based on these novel findings, areas of potential improvement for research and intervention are suggested. de grandiosidad, impasibilidad y búsqueda de emociones y la memoria de trabajo contribuyeron al GC. Conclusiones: La alteración temporal media derecha del GD podría ser indicativa de un desarrollo cerebral alterado en los procesos de cognición social, ya que este rasgo cortical apareció en combinación con el perfil de mayor riesgo. La reducción en el área orbitofrontal podría ser indicativa de un desarrollo cerebral inmaduro en los procesos de control emocional, ya que apareció en combinación con el perfil psicológico normativo en la adolescencia. A partir de estos hallazgos novedosos, se proponen áreas posibles de mejora para la investigación y la intervención.
Effects of Different Types of Chronic Training on Bioenergetic Profile and Reactive Oxygen Species Production in LHCN-M2 Human Myoblast Cells

Human skeletal muscle contains three different types of fibers, each with a different metabolism. Exercise differently contributes to differentiation and metabolism in human myoblast cells. The aims of the present study were to investigate the effects of different types of chronic training on the human LHCN-M2 myoblast cell bioenergetic profile during differentiation in real time and on the ROS overproduction consequent to H2O2 injury. We demonstrated that exercise differently affects the myoblast bioenergetics: aerobic exercise induced the most efficient glycolytic and oxidative capacity and proton leak reduction compared to untrained or anaerobic trained sera-treated cells. Similarly, ROS overproduction after H2O2 stress was lower in cells treated with differently trained sera compared to untrained sera, indicating a cytoprotective effect of training on the reduction of oxidative stress, and thus the promotion of longevity. In conclusion, for the first time, this study has provided knowledge regarding the modifications induced by different types of chronic training on human myoblast cell bioenergetics during the differentiation process in real time, and on ROS overproduction due to stress, with positive implications in terms of longevity.
Economic Evaluation of Multiple-Pharmacogenes Testing for the Prevention of Adverse Drug Reactions in People Living with HIV

Purpose Pharmacogenetics (PGx) testing is one of the methods for determining whether individuals are at risk of adverse drug reactions (ADRs). It has been reported that multiple-PGx testing, a sequencing technology, has a higher predictive value than single-PGx testing. Therefore, this study aimed to determine the most cost-effective PGx testing strategies for preventing drug-induced serious ADRs in human immunodeficiency virus (HIV)-infected patients. Patients and Methods Potential strategies, including 1) single-PGx esting (ie, HLA-B*57:01 testing before prescribing abacavir, HLA-B*13:01 testing before prescribing co-trimoxazole and dapsone, and NAT2 testing before prescribing isoniazid) and 2) multiple-PGx testing as a combination of four single-gene PGx tests in one panel, were all compared to no PGx testing (current practice). To evaluate total cost in Thai baht (THB) and quality-adjusted life years (QALYs) for each strategy-based approach to a societal perspective, a hybrid decision tree and Markov model was constructed. Incremental cost-effectiveness ratios (ICERs) were estimated. Uncertainty, threshold, and scenario analyses were all performed. Results Before prescribing HIV therapy, providing single or multiple-PGx testing might save roughly 68 serious ADRs per year, and the number needed to screen (NNS) to avoid one serious ADR was 40. Consequently, approximately 35% and 40% of the cost of ADR treatment could be avoided by the implementation of single- and multiple-PGx testing, respectively. Compared with no PGx testing strategy, the ICERs were 146,319 THB/QALY gained for single-PGx testing and 152,014 THB/QALY gained for multiple-PGx testing. Moreover, the probability of multiple-PGx testing being cost-effective was 45% at the Thai willingness to pay threshold of 160,000 THB per QALY. Threshold analyses showed that multiple-PGx testing remained cost-effective under the range of cost, sensitivity at 0.95–1.00 and specificity at 0.98–1.00. Conclusion Single and multiple-PGx testing might be cost-effective options for reducing the incidence of drug-induced serious ADRs in people living with HIV.