Miracle-dz/UniFAR-FTUs huggingface dataset:
Differentiating Human Pluripotent Stem Cells to Cardiomyocytes Using Purified Extracellular Matrix Proteins

Human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs) can be differentiated into cardiomyocytes (hESC-CMs and iPSC-CMs, respectively), which hold great promise for cardiac regenerative medicine and disease modeling efforts. However, the most widely employed differentiation protocols require undefined substrates that are derived from xenogeneic (animal) products, contaminating resultant hESC- and iPSC-CM cultures with xenogeneic proteins and limiting their clinical applicability. Additionally, typical hESC- and iPSC-CM protocols produce CMs that are significantly contaminated by non-CMs and that are immature, requiring lengthy maturation procedures. In this review, we will summarize recent studies that have investigated the ability of purified extracellular matrix (ECM) proteins to support hESC- and iPSC-CM differentiation, with a focus on commercially available ECM proteins and coatings to make such protocols widely available to researchers. The most promising of the substrates reviewed here include laminin-521 with laminin-221 together or Synthemax (a synthetic vitronectin-based peptide coating), which both resulted in highly pure CM cultures. Future efforts are needed to determine whether combinations of specific purified ECM proteins or derived peptides could further improve CM maturation and culture times, and significantly improve hESC- and iPSC-CM differentiation protocols.
On weak closure of some diffusion equations

We study the closure of approximating sequences of some diffusion equations under certain weak convergence. A specific description of the closure under weak H 1 H^1 -convergence is given, which reduces to the original equation when the equation is parabolic. However, the closure under strong L 2 L^2 -convergence may be much larger, even for parabolic equations.
On the transpose map of matrix algebras

It is shown that for the transpose map 6(n) of the n X n matrix algebra Mn, its kûi multiplicity map 8(n)k has exactly the norm k if A:<«, hence the completely bounded norm of 6(n) written ||9(n)|| ih equals n. Some applications and related results are also proved. Let M„ be the n X n matrix algebra over the complex field. By Mx we mean the algebra of all bounded linear operators on an infinite-dimensional Hilbert space expressed as the algebra of matrices of infinite order. Let 0(n) (n = 1,2,3,.) be the transpose map in M„. The map 8(n) is an anti-*-automorphism of M„. In this note we shall show some further properties of 0(n), which may contribute to the theory of completely bounded maps between C*-algebras. 1. Throughout this paper we consider M„ as the C*-algebra of all bounded linear operators on an «-dimensional Hilbert space. The tensor product M„ ® Mk is then regarded not only as the matrix C*-algebra Mk(M„) over the algebra Mn but also as the matrix C*-algebra M„(Mk) over Mk. The kth multiplicity map 0(n)k on M„ ® Mk — Mk(M„) is defined by O{n)k[au]=[0(n)(a:j)} on Mk(M„). This is also regarded as the transpose map [b¡¡] -» [b¡¡] on the algebra Mn(Mk). The following lemma is more or less known. We omit the proof. Lemma 1.1. Let M„(A) be the n X n matrix algebra over a C*-algebra A and [ai•] be an element of M „(A). Then, we have that \i/2 \[au]\\<\ 2 V '. / = \a,j H2 '. 7=1 We note that the above estimate is attained in some cases. In fact, the norm of the matrix [ j ¡ ] is equal to 2 and equality also can occur for examples of matrices of any order n. Theorem 1.2. The norms of the multiplicity maps 8(n) (n = 1,2,3,., oo) are k, ifk<n, n, ifk > n. \0{n)k Received by the editors July 20, 1982. 1980 Mathematics Subject Classification. Primary 46L05; Secondary 16A42.
Horizon Instability of Extremal Black Holes

We show that axisymmetric extremal horizons are unstable under linear scalar perturbations. Specifically, we show that translation invariant derivatives of generic solutions to the wave equation do not decay along such horizons as advanced time tends to infinity, and in fact, higher order derivatives blow up. This result holds in particular for extremal Kerr-Newman and Majumdar-Papapetrou spacetimes and is in stark contrast with the subextremal case for which decay is known for all derivatives along the event horizon.
Psychometric Properties of the Online International Physical Activity Questionnaire in College Students

Introduction: Due to the restrictions imposed to control the COVID-19 pandemic, there has been an increase in studies based on online surveys. However, there are important concerns about the validity and generalizability of results from online surveys. Thus, we aimed to test the reliability and validity of the online version of the International Physical Activity Questionnaire short form (IPAQ-SF) among college students from low-income regions. Methods: This was a methodological feasibility study with a random stratified sample from a college located in the state of Maranhão in the city of Imperatriz (Brazil). The sample consisted of 195 college students (at least 17 years of age) to evaluate the validity and 117 students to evaluate the reliability. All data were collected in a self-reported online format (via Google Forms) twice, with an interval of 2 weeks. We used Spearman’s correlation analysis for the reliability study. Additionally, we applied exploratory and confirmatory factor analysis to evaluate the structural validity. Results: The questionnaire showed acceptable (rho > 0.30) and significant (p < 0.05) reliability, except for the question about the duration of sitting time on a weekend day. When assessing the construct validity (exploratory analysis), we identified a single factor that explained 88.8% of the variance. The 1-factor model showed acceptable model fit (SRMR = 0.039; CFI = 0.96; TLI = 0.90) in confirmatory analysis. Conclusions: The online version of the IPAQ-SF has acceptable reliability among college students from low-income regions and maintains the structure of the construct regarding to physical activity.
The Functional Outcomes in Treatment of Displaced Extra Articular Distal Radius Fracture by Pop Alone or K-Wire Augmentation

Background & Objective: A distal radius fracture is responsible for one-sixth visit to the orthopedic emergency room. Although these fractures are common, the best treatment for these fractures is still controversial. The objective of the study was to compare the functional outcomes in terms of union in displaced extra articular distal radius fracture by POP alone or k-wire augmentation. Methods: A comparative study was conducted in the department of orthopedic surgery, Pakistan Institute of Medical Science, Islamabad from June to December 2021. A total of sixty (n=60) adult patients irrespective of gender with distal radial fracture were included in the study. Patients allocated in two groups, Group A included patients who were treated with above elbow POP casting after reducing the fracture, under sedation or blockage of hematoma and Group B included the patients in whom surgery was performed with k-wire by closed reduction and internal fixation. The main outcome measure of the study was functional outcomes in terms of excellent, good and fair. The chi square test was used between study groups for comparison of acceptable outcomes (excellent to good). A p value ≤ 0.05 was considered significant. Results: The average age of the patients of both groups was 38.6±15.8 years. Among 60 patients, 70% (n=42) were male and 30% (n=18) were females. In group A (POP) 30% (n=9) patients showed excellent, 23.3% (n=7) showed good and 46.7% (n=14) showed fair outcome as per our study outcomes. In group B (k-wire) 56.7% (n=17) patients showed excellent, 36.7% (n=11) showed good and 6.6% (n=2) showed fair outcome with p value 0.002. Conclusions: The study concluded that the functional outcomes in terms of union of displaced extra articular distal radius fractures, K-wire fixation showed better results than POP cast alone. Keywords: Bone wires; Casts, Surgical; Internal fixators; Radius fractures.
Molecular high-order harmonic generation with more than one active orbital: Quantum interference effects

We investigate quantum interference effects in high-order harmonic generation in N{sub 2} and N{sub 2}{sup +} beyond the single-active-orbital approximation, with particular emphasis on the role of {sigma} and {pi} orbitals in the overall spectra. In the former case, we consider a simplified multielectron wave function which incorporates the 3{sigma}{sub g} and 1{pi}{sub u} orbitals, and, in the latter, we assume that the optically active electron is in a coherent superposition of the 3{sigma}{sub g} and 1{pi}{sub g}{sup *} one-electron states. If the orbitals are energetically close, such as the 3{sigma}{sub g} and the 1{pi}{sub u} orbitals of N{sub 2}, we show that the quantum interference patterns observed in the high-order harmonic spectra are predominantly determined by the 3{sigma}{sub g} orbital. If, on the other hand, there is a significant difference in their binding energies, such as for the 3{sigma}{sub g} and the 1{pi}{sub g}{sup *} orbitals of N{sub 2}{sup +}, the most loosely bound orbital will determine the shape of the spectra. Due, however, to the different cutoffs encountered, the more deeply bound orbital will leave an imprint on the high-energy harmonics. This holds both for the situation in which the dynamics of the electron is restricted to themore » plane p{sub x}p{sub z} and for the full three-dimensional case, if the azimuthal angle is integrated over and the degeneracy of the {pi} orbitals is taken into account. « less
Coherence and entanglement measures based on Rényi relative entropies

We study systematically resource measures of coherence and entanglement based on Rényi relative entropies, which include the logarithmic robustness of coherence, geometric coherence, and conventional relative entropy of coherence together with their entanglement analogues. First, we show that each Rényi relative entropy of coherence is equal to the corresponding Rényi relative entropy of entanglement for any maximally correlated state. By virtue of this observation, we establish a simple operational connection between entanglement measures and coherence measures based on Rényi relative entropies. We then prove that all these coherence measures, including the logarithmic robustness of coherence, are additive. Accordingly, all these entanglement measures are additive for maximally correlated states. In addition, we derive analytical formulas for Rényi relative entropies of entanglement of maximally correlated states and bipartite pure states, which reproduce a number of classic results on the relative entropy of entanglement and logarithmic robustness of entanglement in a unified framework. Several nontrivial bounds for Rényi relative entropies of coherence (entanglement) are further derived, which improve over results known previously. Moreover, we determine all states whose relative entropy of coherence is equal to the logarithmic robustness of coherence. As an application, we provide an upper bound for the exact coherence distillation rate, which is saturated for pure states.
Aperture synthesis of neutral hydrogen in the galaxy M33

Observations of neutral hydrogen in the galaxy M33 with resolutions of 2' and 10 km s/sup -1/ are described. Detailed modeling has revealed weak evidence for spiral density waves with an arm-interarm contrast of 3 to 2 and with a corotation radius in the range 7' to 12'. It has also disclosed substantial evidence for large-scale warping of the outer plane of this galaxy, similar to that found earlier in M83. (AIP)
Domesticating a Halotolerant Bacterium of Vibrio sp. LY1024 with Heterotrophic Nitrification–Aerobic Denitrification Property for Efficient Nitrogen Removal in Mariculture Wastewater Treatment

Dealing with mariculture wastewater that contains high nitrogenous compounds with efficient biological nitrogen removal technology is challenging but meaningful. The key lies in developing an active microorganism that can spontaneously complete the nitrification–denitrification processes in the marine environment. Herein, a halotolerant heterotrophic nitrification–aerobic denitrification (HN-AD) bacterium of Vibrio sp. LY1024 with good nitrogen removal capacity is domesticated to achieve the aforementioned goal. As a result, ammonium (NH4+-N) and nitrate (NO3−-N) removal rates of almost 100% and 98.5% are detected over Vibrio sp. LY1024 at the salinity of 3.5%, even further increasing the salinity of wastewater to 5.5%. Its removal capacity towards both NH4+-N and NO3−-N can still maintain at almost 100% and 94.7%, respectively. Further combining these results with those of intermediate product determination, it can be speculated that the ammonium removal is according to the pathway of NH4+-N → NH2OH → NO3−-N → N2O → N2. Moreover, the influence of wastewater temperature on the nitrogen removal efficiency of Vibrio sp. LY1024 is also considered. The NH4+-N and NO3−-N removal efficiency over Vibrio sp. LY1024 at a relatively low temperature of 15 °C is still up to 97.3% and 76.4%, respectively. Our work provides a promising halotolerant and low-temperature resistance microorganism for the treatment of mariculture wastewater.
Municipal performance management during the covid pandemic

The COVID-19 pandemic brought a major shift in governmental operations, including decision-making processes. In the midst of an unprecedented crisis, public managers had to make rapid decisions within an uncertain landscape and ambiguous timeline. This exploratory study aims to understand how the pandemic impacted public managers’ behavior as they attempted to better cope with the crisis. In particular, we focus on the impact of the pandemic on performance management practices in municipal governments, examining a range of components, including data analysis and use. Our cross-sectional analysis of 103 line managers from North Carolina municipal departments finds that local government managers increased their use of performance management practices during the pandemic compared to the previous (non-pandemic) year. The increased use was amplified when existing performance information practices were established before the pandemic. These exploratory findings contribute to a better understanding of the role of performance information in decision-making during a crisis and to performance management scholarship more broadly.
Existence of small loops in a bifurcation diagram near degenerate eigenvalues

In this paper, we study the global structure of a bifurcation diagram for rotating doubly connected patches near a degenerate case for incompressible Euler equations. We show that branches with the same symmetry merge, forming a small loop, provided that they are close enough. This gives an analytical proof for the numerical observations conducted in the recent work by de la Hoz et al (2016 SIAM J. Math. Anal. 48 1892–928).
ON NUMBERS, GERMS, AND TRANSSERIES

Germs of real-valued functions, surreal numbers, and transseries are three ways to enrich the real continuum by infinitesimal and infinite quantities. Each of these comes with naturally interacting notions of ordering and derivative. The category of $H$-fields provides a common framework for the relevant algebraic structures. We give an exposition of our results on the model theory of $H$-fields, and we report on recent progress in unifying germs, surreal numbers, and transseries from the point of view of asymptotic differential algebra.
An Examination of Audit Report Lag: Company Size As Moderating Variable

Pengguna laporan keuangan menginginkan laporan yang andal dan tepat waktu karena keterlambatan penyampaian keuangan dapat menyebabkan kesalahan dalam mengambil keputusan ekonomi. Tujuan penelitian ini adalah untuk mengetahui pengaruh kinerja keuangan yang diukur melalui profitabilitas, solvabilitas, likuiditas, ukuran perusahaan, dan faktor lainnya yaitu reputasi auditor dan komite audit terhadap audit report lag dan peran ukuran perusahaan sebagai pemoderasi pengaruh tersebut. Data dari laporan keuangan perusahaan non-keuangan yang terdaftar di Bursa Efek Indonesia (BEI) periode 2016 hingga 2020 digunakan dalam penelitian ini dan melalui metode purposive sampling didapatkan 140 perusahaan yang memenuhi kriteria yang telah ditentukan. Data diolah menggunakan moderated regression analysis dengan hasil pengolahan terhadap 700 data menunjukkan bahwa profitabilitas dan likuiditas, berpengaruh terhadap audit report lag dan ukuran perusahaan memoderasi pengaruh likuiditas terhadap audit report lag dan juga memoderasi pengaruh ukuran komite audit terhadap audit report lag.
A local hermitian RBF meshless numerical method for the solution of multi‐zone problems

The local Hermitian interpolation (LHI) method is a strong‐form meshless numerical technique in which the solution domain is covered by a series of small and heavily overlapping radial basis function (RBF) interpolation systems. Aside from its meshless nature and the ability to work on very large scattered datasets, the main strength of the LHI method lies in the formation of local interpolations, which themselves satisfy both boundary and governing PDE operators, leading to an accurate and stable reconstruction of partial derivatives without the need for artificial upwinding or adaptive stencil selection.
Lagrangian quantum field theory in momentum picture. III. Free vector fields

Free vector fields, satisfying the Lorenz condition, are investigated in details in the momentum picture of motion in Lagrangian quantum field theory. The field equations are equivalently written in terms of creation and annihilation operators and on their base the commutation relations are derived. Some problems concerning the vacuum and state vectors of free vector field are discussed. Special attention is paid to peculiarities of the massless case; in particular, the electromagnetic field is explored. Several Lagrangians, describing free vector fields, are considered and the basic consequences of them are pointed and compared.
Long-Term Outcomes following Common Femoral Endarterectomy

Thromboendarterectomy of the common femoral artery (CFA) for occlusive disease is a crucial procedure in vascular surgery. As an outcome reference for emerging endovascular procedures and new devices, we need more robust evidence of the outcome of this gold standard technique. The purpose of this study was to report 10-year results after femoral endarterectomy (FEA). A retrospective review of medical records at our institution identified eighty consecutive patients (91 limbs) who underwent FEA for CFA lesions. Indications for FEA included 50 limbs (55%) for intermittent claudication (IC) and 39 limbs (43%) with chronic limb-threatening ischemia (CLTI). Two limbs (2%) underwent FEA to prevent hemodynamic steal during extra-anatomical bypass. Adjunctive procedures included endovascular therapy in 32%. CFAs were closed with patch angioplasty in 44%. With a mean follow-up period of 39 months, the survival rates at 3 and 8 years were 85% and 77%, respectively. Limb salvage rates were 92% and 87%. Primary patencies were 98% and 84%. Freedom from target lesion revascularization was 95% at 3 years and 91% at 8 years. Our findings support the durability of FEA, with comparable long-term procedural results in CLTI patients as well as IC patients. Since the FEA is a gate maneuver for hybrid revascularization in CLTI patients, our findings support a strategy combining open and endovascular approaches. Femoral endarterectomy remains a durable solution for common femoral occlusive disease in IC and CLTI in the era of endovascular therapy.
Propagation of Localization Optimal Entropy Production and Convergence rates for the Central Limit Theorem

We prove for the rescaled convolution map $f\to f\circledast f$ propagation of polynomial, exponential and gaussian localization. The gaussian localization is then used to prove an optimal bound on the rate of entropy production by this map. As an application we prove the convergence of the CLT to be at the optimal rate $1/\sqrt{n}$ in the entropy (and $L^1$) sense, for distributions with finite 4th moment.
Global regularity for minimal sets near a $\T$ set and counterexamples

We discuss the global regularity for 2 dimensional minimal sets that are near a $\T$ set, that is, whether every global minimal set in $\R^n$ that looks like a $\T$ set at infinity is a $\T$ set or not. The main point is to use the topological properties of a minimal set at large scale to control its topology at smaller scales. This is the idea to prove that all 1-dimensional Almgren-minimal sets in $\R^n$, and all 2-dimensional Mumford-Shah minimal sets in $\R^3$ are cones. In this article we discuss two types of 2-dimensional minimal sets: Almgren-minimal set in $\R^3$ whose blow-in limit is a $\T$ set; topological minimal sets in $\R^4$ whose blow-in limit is a $\T$ set. For the first one we eliminate an existing potential counterexample that was proposed by several people, and show that a real counterexample should have a more complicated topological structure; for the second we construct a potential example using a Klein bottle.
Ecological regression analysis of environmental benzene exposure and childhood leukaemia: sensitivity to data inaccuracies, geographical scale and ecological bias

Benzene is classified as a group 1 human carcinogen by the International Agency for Research on Cancer, and it is now accepted that occupational exposure is associated with an increased risk of various leukaemias. However, occupational exposure accounts for less than 1% of all benzene exposures, the major sources being cigarette smoking and vehicle exhaust emissions. Whether such low level exposures to environmental benzene are also associated with the risk of leukaemia is currently not known. In this study, we investigate the relationship between benzene emissions arising from outdoor sources (predominantly road traffic and petrol stations) and the incidence of childhood leukaemia in Greater London. An ecological design was used because of the rarity of the disease, the difficulty of obtaining individual level measurements of benzene exposure and the availability of data. However, some methodological difficulties were encountered, including problems of case registration errors, the choice of geographical areas for analysis, exposure measurement errors and ecological bias. We use a Bayesian hierarchical modelling framework to address these issues, and we investigate the sensitivity of our inference to various modelling assumptions.
New Vehiculation Systems of Mometasone Furoate for the Treatment of Inflammatory Skin Diseases

A pre-formulation study was carried out to obtain liposomal formulations of mometasone furoate as an alternative system to marketed forms of corticosteroid for the treatment of inflammatory skin lesions. Mometasone furoate was loaded in glycerosomes and glyceroethosomes, which were also modified with hyaluronic acid (glyceroethohyalurosomes). Vesicles were designed, elaborated, and characterized, and their biocompatibility, efficacy against oxidative stress and skin lesions were assessed in vitro, in human epidermal cells, and in vivo, in a mouse skin epidermal hyperplasia model. All formulations tested showed great encapsulation efficiency, nanometric size, formed monodispersed systems and a highly negative Z potential. Similar values were obtained over nine months storage at 4 °C, which indicates the great stability of the three types of nanoliposomes at least during the time tested. Among them, 0.1% mometasone furoate glyceroethohyalurosomes were the best formulation to protect cells against oxidative stress and their anti-inflammatory efficacy was confirmed in vivo, being even more effective than the marketed form (Elocom®), as the reduction in the inflammation was even ~15% higher than that achieved with the commercial cream. Selected formulations could be potential candidates as new vehiculation systems for mometasone furoate. The presence of hyaluronic acid in glyceroethohyalurosomes makes them the best candidates in preventing/treating skin inflammatory lesions.