Miracle-dz/UniFAR-FTUs huggingface dataset:
Predicting the Intention to Donate Blood among Blood Donors Using a Decision Tree Algorithm

The blood donation process is essential for health systems. Therefore, the ability to predict donor flow has become relevant for hospitals. Although it is possible to predict this behaviour intention from donor questionnaires, the need to reduce social contact in pandemic settings leads to decreasing the extension of these surveys with the minimum loss of predictivity. In this context, this study aims to predict the intention to give blood again, among donors, based on a limited number of attributes. This research uses data science and learning concepts based on symmetry in a particular classification to predict blood donation intent. We carried out a face-to-face survey of Chilean donors based on the Theory of Planned Behaviour. These data, including control variables, were analysed using the decision tree technique. The results indicate that it is possible to predict the intention to donate blood again with an accuracy of 84.17% and minimal variables. The added scientific value of this article is to propose a more simplified way of measuring a multi-determined social phenomenon, such as the intention to donate blood again and the application of the decision tree technique to achieve this simplification, thereby contributing to the field of data science.
Evaluating the Symmetry in Plantar Pressure Distribution under the Toes during Standing in a Postural Pedobarographic Examination

Pedobarography is a safe, non-invasive diagnostic method that enables estimation of plantar pressure distribution. This article aims to describe the symmetry between right and left toes in the Polish adult population using data obtained during postural pedobarographic examinations. Eighty-two patients, both sexes, with a mean age of 42.12 (range 19–70), without significant pathologies, participated in the study. Plantar pressure was evaluated using a PEL38 pressure plate. The study applies the elements of Cavanagh’s classification to identify the foot sole regions: Hallux, Second Toe and Lateral Toe areas and the entire foot surface. The parameters measured included maximal and average pressures, total support area for each foot, and contact area of the foot with the ground at individual moments of standing. The results showed significantly greater loading under the right Hallux in women. As regards men, higher values in the whole foot pressure distribution were noted on the left side. Plantar pressure distribution does not increase along with the global factors such as age and body mass. The findings suggest that the asymmetry in the morphological structure of the foot does not determine the asymmetry in the plantar pressure distribution. None of the feet studied had full symmetry on the entire surface.
Regio- and Stereoselective Synthesis of a New Series of Spirooxindole Pyrrolidine Grafted Thiochromene Scaffolds as Potential Anticancer Agents

A series of new spiro-heterocycles engrafted spirooxindole/pyrrolidine/thiochromene scaffolds was synthesized by the three-component 1,3-dipolar cycloaddition reactions in a fully controlled regio- and stereo-selective fashion. Condensation of several substituted isatin derivatives with L-proline generated the azomethine ylides which subsequently reacted with chalcones based thiochromene scaffold, and finally afforded the target spiro-compounds. This simple protocol furnished a structurally complex, biologically relevant spiro-heterocycles in good yields through a one-pot process. All synthesized chalcone-based thiochromene, along with the spirooxindole/pyrrolidine/thiochromene scaffolds, were tested for their anticancer activity against four cancer cell lines (PC3, HeLa, MCF-7, and MDA-MB231). Toxicity of these compounds was also evaluated against human fibroblast BJ cell line, and they appeared to be not cytotoxic. For the prostate cancer (PC3) cell line, the most active hybrid, among synthesized series, was compound (7f, IC50 = 8.7 ± 0.7 µM). The most potent spirooxindole/pyrrolidine/thiochromene hybrid against cervical (HeLa) cancer cells was compound (7k, IC50 = 8.4 ± 0.5 µM) having chlorine and p-trifluoromethyl substituents attached to phenyl rings. Finally, against the MCF-7 and MDA-MB231 breast cancer cell lines, compound (7d) was the most active member of this series (IC50 = 7.36 ± 0.37, and 9.44 ± 0.32 µM, respectively).
Effects of Exercise Intensity on Pedal Force Asymmetry during Cycling

The purpose of the current investigation was to examine the effects of exercise intensity and a participant’s cycling experience on asymmetry in pedal forces during cycling. Participants were classified as cycling experienced (CE) or non-cycling experienced (NCE) based on self-reported training history. Participants completed an incremental cycling test via a cycle ergometer with inspired and expired gases, capillary blood lactate and pedaling forces collected throughout the test. Group X exercise intensity comparisons were analyzed at workloads corresponding to 2 mmol/L and 4 mmol/L for the blood lactate accumulation and peak power output, respectively. No Group X exercise intensity interactions for any variables (p > 0.05) were observed. The main effect on the exercise intensity was observed for absolute (p = 0.000, η2 = 0.836) and relative (p = 0.000, η2 = 0.752) power outputs and pedal force effectiveness (PFE) (p = 0.000, η2 = 0.728). The main effect for the group was observed for absolute (p = 0.007, η2 = 0.326) and relative (p = 0.001, η2 = 0.433) power outputs, the absolute difference between the lower limbs in power production (p = 0.047, η2 = 0.191), the peak crank torque asymmetry index (p = 0.031, η2 = 0.222) and the PFE (p = 0.014, η2 = 0.280). The exercise intensity was observed to have no impact on asymmetry in pedaling forces during cycling.
An Entropic Gradient Structure in the Network Dynamics of a Slime Mold

The approach to equilibrium in certain dynamical systems can be usefully described in terms of information-theoretic functionals. Well-studied models of this kind are Markov processes, chemical reaction networks, and replicator dynamics, for all of which it can be proven, under suitable assumptions, that the relative entropy (informational divergence) of the state of the system with respect to an equilibrium is nonincreasing over time. This work reviews another recent result of this type, which emerged in the study of the network optimization dynamics of an acellular slime mold, Physarum polycephalum. In this setting, not only the relative entropy of the state is nonincreasing, but its evolution over time is crucial to the stability of the entire system, and the equilibrium towards which the dynamics is attracted proves to be a global minimizer of the cost of the network.
The Role of β-Arrestin1 in Esophageal Squamous Cell Carcinoma

Introduction Esophageal squamous cell carcinoma (ESCC) is the predominant type of esophageal carcinoma with a low survival rate and a poor prognosis. Therefore, it is of great significance to explore the effective tumor markers in early diagnosis, treatment monitoring and prognosis evaluation of ESCC. The current study was designed to explore the important role of β-arrestin1 in ESCC and the underlying mechanism. Methods The defined effects of β-arrestin1 on cell proliferation, migration, invasion, EMT and tumor growth were investigated both in ESCC cells and in vivo model of ESCC. β-arrestin1 expression was detected using Western blot and immunohistochemistry assay. The cell proliferation ability was determined using CCK-8 assay. Wound healing assay and trans-well invasion assay were performed to determine cell migration and invasion. The key proteins related to cell migration, invasion and EMT were detected by Western blot. Tumor growth in vivo was also monitored by tumor volume and weight. In addition, the effects of β-arrestin1 on AKT/GSK3β/β-catenin pathway were evaluated. Results β-arrestin1 was aberrantly upregulated in human ESCC tissues, ESCC cell lines and animal model of ESCC. β-arrestin1 downregulation inhibited cell proliferation, migration, invasion and EMT of ESCC in vitro and vivo. β-arrestin downregulation also suppressed tumor growth in vivo model of ESCC. In addition, the inhibitory effects of β-arrestin1 downregulation were exerted via AKT/GSK3β/β-catenin signaling pathway. Discussion The results in the present study together confirmed the truth that β-arrestin1 interference may suppress ESCC cell proliferation, migration, invasion, EMT and tumor growth via AKT/GSK3β/β-catenin signaling pathway.
Implementation of chemometrics as a Solution to detecting and preventing falsification of herbal medicines in Southeast Asia: A review

Herbal medicine has been known for centuries as one of the sophisticated traditional medicine systems and is widely used in Southeast Asia. Based on their beneficial and economical values, herbal medicines are sometimes found falsified. Chemometrics is a potential tool be developed to detect and prevent falsification. This review aimed to explore the application of chemometrics using certain chemical and biological responses for detecting the adulteration of herbal medicines in Southeast Asia. The study was carried out as a narrative review to evaluate published papers between 2000 and 2020. A total of 34 papers met the inclusion criteria and were reviewed and evaluated. Reviewed articles reveal that chemometrics successfully detected the falsification of herbal medicine with great accuracy and flexibility. Chemometrics was advantageous, practical, and cost-effective to detect adulteration and prevent falsification of herbal medicines. Nonetheless, the data published still diminish compared to the number of herbal medicines in Southeast Asia. Updated, verified, and integrated data among Southeast Asia researchers may be collected to sharpen the chemometric method. The implementation of chemometrics in Southeast Asia to detect and prevent herbal medicines was fundamental and increased the potency of herbal medicines.
Remarks on Modeling the Oil Film Generation of Rod Seals

The oil film generation of a U-cup rod seal and the oil film thickness on the rod after outstroke were analyzed analytically, numerically, and experimentally. The analyzed sealing system consists of an unmodified, commercially available U-cup, a polished rod, and mineral oil. The inverse theory of hydrodynamic lubrication (IHL) and an elastohydrodynamic lubrication (EHL) model—both based on the Reynolds equation for thin lubricating films—were utilized to simulate the oil film generation. In the EHL analysis, physical parameters and numerical EHL parameters were varied. Both the analytical and numerical results for the varied parameters show that the film thickness follows a square-root function (i.e., with a function exponent of 0.5) with respect to the product of dynamic viscosity and rod speed, also referred to as the duty parameter. In comparison to the analytical and numerical results, the film thickness obtained via ellipsometry measurements is a function of the duty parameter with an exponent of approximately 0.85. Possible causes for the discrepancy between theory and experiments are discussed. A potential remedy for the modeling gap is proposed.
Follicular Helper CD4+ T Cells, Follicular Regulatory CD4+ T Cells, and Inducible Costimulator and Their Roles in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis

Follicular helper CD4+ T (TFH) cells are a specialized subset of effector T cells that play a central role in orchestrating adaptive immunity. TFH cells mainly promote germinal center (GC) formation, provide help to B cells for immunoglobulin affinity maturation and class-switch recombination of B cells, and facilitate production of long-lived plasma cells and memory B cells. TFH cells express the nuclear transcriptional repressor B cell lymphoma 6 (Bcl-6), the chemokine (C-X-C motif) receptor 5 (CXCR5), the CD28 family members programmed cell death protein-1 (PD-1) and inducible costimulator (ICOS) and are also responsible for the secretion of interleukin-21 (IL-21) and IL-4. Follicular regulatory CD4+ T (TFR) cells, as a regulatory counterpart of TFH cells, participate in the regulation of GC reactions. TFR cells not only express markers of TFH cells but also express markers of regulatory T (Treg) cells containing FOXP3, glucocorticoid-induced tumor necrosis factor receptor (GITR), cytotoxic T lymphocyte antigen 4 (CTLA-4), and IL-10, hence owing to the dual characteristic of TFH cells and Treg cells. ICOS, expressed on activated CD4+ effector T cells, participates in T cell activation, differentiation, and effector process. The expression of ICOS is highest on TFH and TFR cells, indicating it as a key regulator of humoral immunity. Multiple sclerosis (MS) is a severe autoimmune disease that affects the central nervous system and results in disability, mediated by autoreactive T cells with evolving evidence of a remarkable contribution from humoral responses. This review summarizes recent advances regarding TFH cells, TFR cells, and ICOS, as well as their functional characteristics in relation to MS.
Journal of Neuroscience and Neurological Surgery

Received date: August 29,2018; Accepted date : September 05, 2018; Published date: September 10, 2018. Citation for this Article: : Adrian Kelly, Cranial injuries secondary to community mob assault, J Neuroscience and Neurological Surgery. Doi: 10.31579/2578-8868/036. Copyright : © 2018 Adrian Kelly. This is an open-access article distributed under the terms of The Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Factors Affecting Hedonic Brand Loyalty on the Fine Dining Indonesian Food Restaurant in Jakarta

Consumers experience of various emotions, simultaneously or successively when interacting with the service providers (Maguire & Geiger, 2015). Recently the findings of Bilgihan et al. (2016) consider the key of the emotional role in services and emphasizes that in the context of service companies have to pay more attentions to the consumer’s emotions to increase the loyalty df customers. The role and effects of emotions attract more attention from the marketing intellectuals in Indonesia in their search for a better understanding of consumers and the consumption experience (Mattila and Enz, 2002; Ladhari, 2007).
Biosorption of bemacid red dye by brewery waste using single and poly-parametric study

Brewery waste is used as a low-cost adsorbent to remove the BemacidRed dye. Effect of parameters: pH solution, initial dye concentration, adsorbent mass and contact time on the dye removal are determined by single parametric kinetic study. Two type forms of equilibrium isotherm are tested Langmuir and Freundlich models. The best fit of equilibrium data with maximum amount removal of 142 mg/g (pH = 2, contact time = 60 min, adsorbent mass = 50 mg) is provided by Langmuir isotherm. The poly-parametric study using the complete factorial design approach is performed. Residual analysis was used to confirm the validity of the linear model with first order interaction obtained by the poly-parametric method. It was observed that the initial pH have an important negative effect equal to –14 on Bemacid Red dye elimination. In contrast, the initial dye concentration has positive effect equal to +11. Furthermore, the results of the poly-parametric study are consistent and significant compared to the results of single-parametric study with a reduced number of experiments. These conclusions available to consider that the brewery waste can be successfully applied for the Bemacid Red dye removal.
Large eddy simulation of the low temperature ignition and combustion processes on spray flame with the linear eddy model

Large eddy simulation coupled with the linear eddy model (LEM) is employed for the simulation of n-heptane spray flames to investigate the low temperature ignition and combustion process in a constant-volume combustion vessel under diesel-engine relevant conditions. Parametric studies are performed to give a comprehensive understanding of the ignition processes. The non-reacting case is firstly carried out to validate the present model by comparing the predicted results with the experimental data from the Engine Combustion Network (ECN). Good agreements are observed in terms of liquid and vapour penetration length, as well as the mixture fraction distributions at different times and different axial locations. For the reacting cases, the flame index was introduced to distinguish between the premixed and non-premixed combustion. A reaction region (RR) parameter is used to investigate the ignition and combustion characteristics, and to distinguish the different combustion stages. Results show that the two-stage combustion process can be identified in spray flames, and different ignition positions in the mixture fraction versus RR space are well described at low and high initial ambient temperatures. At an initial condition of 850 K, the first-stage ignition is initiated at the fuel-lean region, followed by the reactions in fuel-rich regions. Then high-temperature reaction occurs mainly at the places with mixture concentration around stoichiometric mixture fraction. While at an initial temperature of 1000 K, the first-stage ignition occurs at the fuel-rich region first, then it moves towards fuel-richer region. Afterwards, the high-temperature reactions move back to the stoichiometric mixture fraction region. For all of the initial temperatures considered, high-temperature ignition kernels are initiated at the regions richer than stoichiometric mixture fraction. By increasing the initial ambient temperature, the high-temperature ignition kernels move towards richer mixture regions. And after the spray flames gets quasi-steady, most heat is released at the stoichiometric mixture fraction regions. In addition, combustion mode analysis based on key intermediate species illustrates three-mode combustion processes in diesel spray flames.
Spatial Analysis of Citizens’ Environmental Complaints in China: Implications in Environmental Monitoring and Governance

Citizen environmental complaints play a key role in China’s current environmental monitoring network and environmental governance system. Based on 5796 cases of environmental complaints lodged by citizens via hotline and the internet to the MEP of China, we examined the spatial characteristics and influencing factors of citizen complaints for the period of 2013–2017 using spatial analysis methods and spatial econometric models. The roles of citizen complaints in the two systems were then reevaluated. The results show that, among all cases, 75.88% of cases were identified as verified complaints, while nearly a 25% noisy rate directed large amounts of inspection resources to be utilized in response to nonverified cases. Air pollution received the most attention by citizens in China, accounting for 67.22% of total cases. The hotspots of citizen complaints were mostly distributed in the three major national urban agglomerations in China. We found that industrial wastewater and SO2 were positively associated with the likelihood of citizens filing complaints, while the effect of industrial soot/dust emission was insignificant. Citizen complaints might be triggered by certain, but not all, forms of pollutants, even though highly visible particulate pollutants did not necessarily induce corresponding complaints. Moreover, the negative relationship between citizen complaints and per capita GDP revealed the unbalanced geographical pattern between economical development and environmental quality. The proliferation of the internet greatly facilitated citizens lodging complaints through various ways. The synergy mechanism between citizen environmental complaints and other parts in China’s environmental monitoring and governance system should be established in the future.
GMD manuscript #2020-404: replies to the reviews

This study examined performance of various MPDATA variants in solving drop size distribution evolution by condensation. The authors reviewed many previous studies in the context of improving MPDATA and showed that MPDATA with three anti-diﬀusive iterations, third order term, inﬁnite gauge, and the non-oscillatory option reduces the numerical diﬀusion to roughly a tenth compared to that of the upwind scheme, although it requires ∼ 10 times longer than the upwind scheme.
Separation Axioms ( T 1 ) on Fuzzy Bitopological Spaces in Quasi-Coincidence Sense

: In this paper, we introduce some new deﬁnitions of T 1 separation on fuzzy bitopological space in quasi-coincidence sense and establish relations among them and their counterparts. We show that the notions satisfy good extension, hereditary, productive and projective properties. We present their one-one, onto, fuzzy open and fuzzy continuous mappings. In addition, we also discuss the initial and ﬁnal fuzzy bitopological spaces in quasi-coincidence sense.
Self-Aligned Thin-Film Patterning by Area-Selective Etching of Polymers

Patterning of thin films with lithography techniques for making semiconductor devices has been facing increasing difficulties with feature sizes shrinking to the sub-10 nm range, and alternatives have been actively sought from area-selective thin film deposition processes. Here, an entirely new method is introduced to self-aligned thin-film patterning: area-selective gas-phase etching of polymers. The etching reactions are selective to the materials underneath the polymers. Either O2 or H2 can be used as an etchant gas. After diffusing through the polymer film to the catalytic surfaces, the etchant gas molecules are dissociated into their respective atoms, which then readily react with the polymer, etching it away. On noncatalytic surfaces, the polymer film remains. For example, polyimide and poly(methyl methacrylate) (PMMA) were selectively oxidatively removed at 300 °C from Pt and Ru, while on SiO2 they stayed. CeO2 also showed a clear catalytic effect for the oxidative removal of PMMA. In H2, the most active surfaces catalysing the hydrogenolysis of PMMA were Cu and Ti. The area-selective etching of polyimide from Pt was followed by area-selective atomic layer deposition of iridium using the patterned polymer as a growth-inhibiting layer on SiO2, eventually resulting in dual side-by-side self-aligned formation of metal-on-metal and insulator (polymer)-on-insulator. This demonstrates that when innovatively combined with area-selective thin film deposition and, for example, lift-off patterning processes, self-aligned etching processes will open entirely new possibilities for the fabrication of the most advanced and challenging semiconductor devices.