Miracle-dz/UniFAR-FTUs huggingface dataset:
Prediction of Mortality in Older Hospitalized Patients after Discharge as Determined by Comprehensive Geriatric Assessment

Several dimensional impairments regarding Comprehensive Geriatric Assessment (CGA) have been shown to be associated with the prognosis of older patients. The purpose of this study is to investigate mortality prediction factors based upon clinical characteristics and test in CGA, and then subsequently develop a prediction model to classify both short- and long-term mortality risk in hospitalized older patients after discharge. A total of 1565 older patients with a median age of 81 years (74.0–86.0) were consecutively enrolled. The CGA, which included assessment of clinical, cognitive, functional, nutritional, and social parameters during hospitalization, as well as clinical information on each patient was recorded. Within the one-year follow up period, 110 patients (7.0%) had died. Using simple Cox regression analysis, it was shown that a patient’s Length of Stay (LOS), previous hospitalization history, admission Barthel Index (BI) score, Instrumental Activity of Daily Living (IADL) score, Mini Nutritional Assessment (MNA) score, and Charlson’s Comorbidity Index (CCI) score were all associated with one-year mortality after discharge. When these parameters were dichotomized, we discovered that those who were aged ≥90 years, had a LOS ≥ 12 days, an MNA score < 17, a CCI ≥ 2, and a previous admission history were all independently associated with one-year mortality using multiple cox regression analyses. By applying individual scores to these risk factors, the area under the receiver operating characteristics curve (AUC) was 0.691 with a cut-off value score ≧ 3 for one year mortality, 0.801 for within 30-day mortality, and 0.748 for within 90-day mortality. It is suggested that older hospitalized patients with varying risks of mortality may be stratified by a prediction model, with tailored planning being subsequently implemented.
The Effect of Climate Change on Environmental-Based Diseases in Palu City in 2015-2020

The purpose of this study was to determine the effect of climate change (temperature, humidity, wind speed, rainfall, and rainy days) on environmental-based diseases (DHF and ARI) in Palu City in 2015-2020. This study uses a quantitative method with an ecological study design. The sampling technique used total sampling where the samples were all cases of DHF and ARI from the Palu City Health Office and climate data from the Mutiara Palu Meteorological Station from 2015-2020. Data analysis using multiple linear regression test. The results of the study for the incidence of DHF showed, partially temperature (0.384 > 0.05), wind speed (0.873 > 0.05), rainfall (0.868 > 0.05). 0.05) and rainy days (0.608 > 0.05) had no effect on the incidence of DHF because the significance value was greater than 0.05. Simultaneously the test results obtained are (0.628 > 0.05), meaning that there is no significant effect between climate change and the incidence of DHF in Palu City because the F test results show a significance value greater than 0.05. The incidence of ARI shows that part there is a significant effect of temperature and humidity on the incidence of ARI with the same significant value (0.00 < 0.05) and positive (+) pattern, and there is a significant effect of wind speed and rainfall on the incidence of ARI with the same significant value (0.00 < 0.05) but with a negative pattern. The conclusion is that there is a significant effect of climate change on the incidence of ARI.
Representações sociais de pessoas com diabetes acerca do apoio familiar percebido em relação ao tratamento

The objective of this qualitative study was to identify the social representations that people with diabetes have on their perception of family support for the treatment. The Theory of Social Representations was used as the theoretical and methodological framework. Participants were 41 people with diabetes assisted at a university in the state of Sao Paulo in 2007. The focal group strategy was used for data collection, and thematic content analysis was performed. Results revealed three categories: family support is present in the everyday life of people with diabetes; the family does not always support the person with diabetes in his or her needs; the person with diabetes assumes the responsibility to trigger family support. Participants see family support as a relevant factor for the treatment, but they also point out that excessive control from relatives limits their autonomy and originates ambiguous feelings. The multiprofessional team must take into consideration that knowing social representations helps improve the health care delivered to people with diabetes.
Evaluating the levels of interleukin-6 and interleukin-10 as potential biomarkers for the severity and mortality in COVID-19 patients

Objective: Evaluating the levels of pro-inflammatory cytokine (IL-6) and anti-inflammatory cytokine (IL-10) among patients with COVID-19. Methodology: A study is conducted during the period from 1st November 2021 to 1 st April 2022 , 110 patients were diagnosed as COVID-19. Their ages range between 20-81 and more years old, Who attended to AL-Amal Specialized Hospital for Communicable Diseases at first week of infection with symptoms (fever, Headache, cough, shortness of breath, diarrhea, loss of taste and smell), and compared with 50 apparently healthy individuals as control group. The diagnosis of each case was established using clinical diagnosis and confirmed by reverse transcriptase polymerase chain reaction (rt-PCR), 5 ml of fresh venous blood samples were collected from COVID-19 infected patients by sterile syringes and saved in serum separator tube (SST) with specific gel to easy sorting the serum, then left for 20 minutes at room temperature. After coagulation, sera were separated by centrifuge 4000xg for 15 minutes and directly stored at -20 ºC to be analyzed later for IL-6 and IL-10 assay.
A REVIEW ON ANALOGUES OF BETA ODAP IN TREATMENT OF NEUROLATHYRISM SHOWING DOCKING AFFINITY

L athyrism or neurolathyrism is a neurological disease of humans and domestic animals, caused by eating certain legumes like Lathyrus sativus also known as Grass pea, containing the toxin β-oxalyl-L-α,β-diaminopropionic acid (ODAP). This consumption containing high concentrations of the glutamate analogue neurotoxin beta ODAP causes paralysis by binding at AMPA selective ionotropic glutamate receptors and blocking glutamate transport in the neural milieu and triggering excitotoxic degeneration of neurons, and may involve pyramidal tracts producing signs of upper motor neuron damage. The toxin may also cause aortic aneurysm. ODAP is a poison of mitochondria, leading to excess cell death, especially in motor neurons Children can additionally develop bone deformity and reduced brain development. Recent research suggests that sulfur amino acids have a protective effect against the toxicity of ODAP by applying docking property some researchers have proved to minimise the effect of toxic by developing analogues of beta ODAP with competitively binding to the respective receptor and decrease the neurotoxicity Carboxymethyl alpha, beta-diaminopropanoic acid (CMDAP) N-acetyl-alpha, beta- diaminopropanoic acid (ADAP), Carboxymethylcysteine (CMC). Ligand binding studies demonstrated that all the three compounds were effective to in displacing glutamate. The maximum inhibition was 92% for CMDAP, 61% for ADAP, 65% for CMC. These data indicate that analogues of beta-ODAP may interact with glutamate receptors without producing neurotoxicity.
The Additional Medical Expenditure Caused by Depressive Symptoms among Middle-Aged and Elderly Patients with Chronic Lung Diseases in China

Depression is one of the most common comorbidities in patients with chronic lung diseases (CLDs). Depressive symptoms have an obvious influence on the health function, treatment, and management of CLD patients. In order to investigate the additional medical expenditure caused by depressive symptoms among middle-aged and elderly patients with CLDs in China, and to estimate urban–rural differences in additional medical expenditure, our study used data from the 2018 China Health and Retirement Longitudinal Study (CHARLS) investigation. A total of 1834 middle-aged and elderly CLD patients were included in this study. A generalized linear regression model was used to analyze the additional medical expenditure on depressive symptoms in CLD patients. The results show that depressive symptoms were associated with an increase in medical costs in patients with CLDs. Nevertheless, the incremental medical costs differed between urban and rural patients. In urban and rural patients with more severe comorbid CLD and depressive symptoms (co-MCDs), the total additional medical costs reached 4704.00 Chinese Yuan (CNY) (USD 711.60) and CNY 2140.20 (USD 323.80), respectively. Likewise, for patients with lower severity co-MCDs, the total additional medical costs of urban patients were higher than those of rural patients (CNY 4908.10 vs. CNY 1169.90) (USD 742.50 vs. USD 176.90). Depressive symptoms were associated with increased medical utilization and expenditure among CLD patients, which varies between urban and rural areas. This study highlights the importance of mental health care for patients with CLDs.
Epstein-Barr Virus-Positive Not Otherwise Specified (EBV+ NOS) Lymphoma Presentation of Primary Bone Tumor Underlying a Pathological Fracture

Diffuse large B-cell lymphoma (DLBCL) is the most common non-Hodgkin's lymphoma (NHL) and accounts for approximately 25% of all NHLs in developed countries. The patients usually present with constitutional symptoms and rapidly enlarging lymphadenopathy and symptomatic mass typically located in the neck or abdomen, along with an aggressive disease course. Most of the patients present with advanced disease with 60% presenting with stage 3 or 4, and those who present with extranodal involvement are usually seen at an earlier stage. Different conditions are associated with non-Hodgkin’s lymphoma ranging from hereditary immunodeficiency disorders, autoimmune disorders, infections such as HIV, Epstein-Barr virus (EBV), hepatitis C virus (HCV), Helicobacter pylori, and drugs such as immunosuppressants and chemotherapeutic agents. Epstein-Barr virus (EBV) is the main etiology of DLBCLs with an identified cause and it accounts for 10% of all DLBCLs. We report a case of a 51-year-old woman who came with a non-traumatic left femur fracture and was subsequently found to have EBV-positive DLBCL. Lymphoma commonly presents as a lymph node swelling and it’s uncommon to present as primary bone disease.
The Frequency of Primary Healthcare Contacts Preceding the Diagnosis of Lower-Extremity Arterial Disease: Do Women Consult General Practice Differently?

Background. Women with lower-extremity arterial disease (LEAD) are often underdiagnosed, present themselves with more advanced disease at diagnosis, and fare worse than men. Objective. To investigate to what extent potential gender differences exist in the frequency and reasons for general practitioner (GP) consultation six months prior to the diagnosis of LEAD, as potential indicators of diagnostic delay. Methods. Individuals older than 18 years diagnosed with LEAD, sampled from the Julius General Practitioner’s Network (JGPN), were included and compared with a reference population, matched (1:2.6 ratio) in terms of age, sex, and general practice. We applied a zero-inflated negative binomial (ZINB) regression model. Results. The study population comprised 4044 patients with LEAD (43.5% women) and 10,486 subjects in the reference population (46.3% women). In the LEAD cohort, the number of GP contacts was 2.70 (95% CI: 2.42, 3.02) in women and 2.54 (2.29, 2.82) in men. In the reference cohort, 1.77 (95% CI: 1.62, 1.94) in women and 1.63 (95% CI: 1.50, 1.78) in men. In the LEAD cohort, 21.9% of GP contacts occurred one month prior to diagnosis. In both cohorts and both sexes, the most common cause of consultation during the last month before the index date was cardiovascular problems. Conclusions. Six months preceding the initial diagnosis of LEAD, patients visit the GP more often than a similar population without LEAD, regardless of gender. Reported gender differences in the severity of LEAD at diagnosis do not seem to be explained by a delay in presentation to the GP.
Authentication of Harpullia arborea (Blanco) Radlk. - a traditional medicinal plant from India using microscopic techniques

Harpullia arborea (Blanco) Radlk. , Sapindaceae, known as “black doll’s eyes” or “tulip tree” is a rainforest tree distributed in the tropical forests of peninsular India. Out of the 26 species of the genus, H. arborea is therapeutically more studied and widely used in folk and ayurvedic medicine. In this work, anatomical study of the leaves and stem of H. arborea was performed to provide a microscopical diagnosis for its characterization due to its increasing use in folk and ayurvedic medicine and its differentiation from other species with the same popular name. Standard light and scanning electron microscopy procedures were carried out using paradermal sections of leaf surfaces and transverse sections of lamina, midrib, and petiole. Stem preparations include longitudinal, radial and transverse sections of tertiary branches. The leaf epidermis with stellate non-glandular trichomes, cyclocytic stomata, mucilaginous cells and mesophyll without secretory sclereids, and the stem with confluent axial parenchyma, biseriate xylem rays, and the presence of rhomboidal prismatic crystals in the axial cells are the diagnostic microscopic features of the species. This structural characterization of the stem and leaf allows the identification of H.arborea, allowing certification of the authenticity of raw material.
Psychological Benefits of Purchasing Home Meal Replacement in the Context of Eco-Friendly TV Home Shopping Broadcast: The Moderating Role of Personal Norm

This study observed the relationship between psychological benefits and the theory of planned behavior (TPB) in the context of an eco-friendly TV home shopping broadcasts. The theoretical framework was enhanced even further by examining the moderating role of personal norm on proenvironmental attitudes in the TV home shopping context. An online survey was conducted with Korean customers who had purchased home meal replacement (HMR) products from a TV home shopping broadcast within the past 6 months. A total of 305 samples were collected and used for the data analysis. All six of the hypotheses in the psychological benefits and TPB model were supported, meaning all constructs of psychological benefits, including warm glow, self-expressive benefits, and nature experiences, impacted TPB and behavioral intentions. Furthermore, personal norm had a moderating role in the relationship between warm glow and attitude. This research provides significant theoretical and managerial implications for the home shopping industry.
Correlation coefficient calculations for MIMO antenna systems: a comparative study

The correlation coefficient (ρ) is an important metric for the evaluation of multiple-input–multiple-output (MIMO) antenna systems because it describes the relationship between the channels in a particular propagation environment. Highly correlated channels will degrade the MIMO system performance. Various methods to calculate ρ are analyzed in this work using three different types of antennas with different efficiencies and radiating properties. While the field-based method for finding ρ gives the most accurate results and should be used all the time. It is independent of antenna efficiency. The the S-parameter-based method might give reasonable results only when the antenna efficiency is very high and the patterns are separated in space, but in most cases, it underestimates ρ values and thus is not a reliable method and should be avoided. Incorporating the antenna efficiency can improve the ρ estimates using the S-parameters method under some specific conditions. The equivalent circuit method provides reasonable results for symmetric antenna structures only, and is the most complex in formulation. As part of the evaluation, two existing methods incorporating the radiation efficiency of the antennas are generalized to N-ports for the first time. Although less accurate than the field-based method, these extensions allow the evaluation of ρ for N-port antennas using only the radiation efficiency and the S-parameters of the antenna. The effect of the beam tilts on ρ estimation is investigated for the first time.
Investigating the Factors Causing Price Differences from Country to Country

This study investigated the factors causing differences in the prices of MNC operating in different countries that affect the pricing in different regions and deviating from the law of one price and influencing factors by comparing prices of both India and Pakistan being developing countries. The study focused on some specific variables such as GDP, exchange rate, purchasing power parity, and price in the dollar that have been analyzed from January 2016 to January 2021 based on biannual data. The quantitative approach has been applied and the study is based on secondary data, Statistics are taken from the “Big Mac Index” which is used as a benchmark for the comparison of the prices to have a deep insight about prices. The product taken for comparison between 2 countries is “The Big Mac” which is a product of McDonald’s (A multinational corporation) that operates more than 36,000 restaurants in more than 100 countries around the world. The tool used for the analysis of the collected data is Microfit software. Results show currency value, Dollar exchange, and Dollar GDP is statistically not significant, in the case of India analysis shows that dollar exchange, dollar GDP, and dollar PPP having values 0.047, 0.004, and 0.011 respectively are significant and currency value 0.458 & dollar price 0.11 are not significant.
Catalytic effect of acetate (C2H3O2) on coulombic efficiency and bio-electricity generation from wastewater sample prepared from domestic kitchen waste using dual chamber microbial fuel cell technology

In recent times, the use of energy resources, particularly non-renewable resources, have increased manifolds due to the ever-increasing global demands. This has led to an increase in depletion of the resources and environmental pollution. Microbial Fuel Cells (MFC) are a new concept that has proved to be the solution to the problem as a green energy resource. The paper focuses on generating electricity from wastewater prepared from kitchen wet waste kept for about 168 hours in an attempt to address the energy crisis while also treating it. A comparative analysis of the sample as prepared and with acetate has been studied and power generation, coulombic efficiency and change in chemical oxygen demand (COD) for wastewater were calculated and also the catalytic effect of acetate was analyzed. It was observed that there was a substantial increase in coulombic efficiency and COD content . A coulombic Efficiency efficiency of 25.29% was obtained for the sample with acetate, whereas, without acetate it was calculated as 9.71%. The maximum power density was obtained from the polarization curves. It was observed that the maximum power density of pure kitchen wastewater was found to be 0.017 mW/m2; however, for kitchen wastewater with acetate, the power density increased considerably to 0.546 mW/m2 at an external resistance of 1Kῼ. Further, the maximum current densities observed were 2.239 mA/m2 and 8.771 mA/m2, respectively. The internal resistance of the constructed prototypes was also determined using the maximum power transfer theorem. In this study, a prototype was constructed and it was found that kitchen waste can be used as a source of electricity generation and leads to a green energy initiative.
On the dynamic analysis of rotating shafts using nonlinear superelement and absolute nodal coordinate formulations

In this article, a superelement formulation and a quadratic beam element based on the absolute nodal coordinate formulation are applied to the simulation of high-speed rotating structures. To this end, these formulations are briefly reviewed by highlighting their distinctive features. The performance of the studied formulations is examined using two numerical examples. The first test is a spinning beam example in which the transient response is examined. An unbalanced rotating shaft is studied in the second example, in which both transient and modal analyses are performed. The results produced using both formulations are compared against those produced in the commercial finite element software ANSYS and those available in literature. The article tests in a rotating machine dynamics context two element types which have not been formulated primarily with rotating applications in mind. This is useful in investigating the versatility of these elements.
Photorhabdus luminescens TccC3 Toxin Targets the Dynamic Population of F-Actin and Impairs Cell Cortex Integrity

Due to its essential role in cellular processes, actin is a common target for bacterial toxins. One such toxin, TccC3, is an effector domain of the ABC-toxin produced by entomopathogenic bacteria of Photorhabdus spp. Unlike other actin-targeting toxins, TccC3 uniquely ADP-ribosylates actin at Thr-148, resulting in the formation of actin aggregates and inhibition of phagocytosis. It has been shown that the fully modified F-actin is resistant to depolymerization by cofilin and gelsolin, but their effects on partially modified actin were not explored. We found that only F-actin unprotected by tropomyosin is the physiological TccC3 substrate. Yet, ADP-ribosylated G-actin can be produced upon cofilin-accelerated F-actin depolymerization, which was only mildly inhibited in partially modified actin. The affinity of TccC3-ADP-ribosylated G-actin for profilin and thymosin-β4 was weakened moderately but sufficiently to potentiate spontaneous polymerization in their presence. Interestingly, the Arp2/3-mediated nucleation was also potentiated by T148-ADP-ribosylation. Notably, even partially modified actin showed reduced bundling by plastins and α-actinin. In agreement with the role of these and other tandem calponin-homology domain actin organizers in the assembly of the cortical actin network, TccC3 induced intense membrane blebbing in cultured cells. Overall, our data suggest that TccC3 imposes a complex action on the cytoskeleton by affecting F-actin nucleation, recycling, and interaction with actin-binding proteins involved in the integration of actin filaments with each other and cellular elements.