Miracle-dz/UniFAR-FTUs huggingface dataset:
The multifaceted role of lemur tyrosine kinase 3 in health and disease

In the last decade, LMTK3 (lemur tyrosine kinase 3) has emerged as an important player in breast cancer, contributing to the advancement of disease and the acquisition of resistance to therapy through a strikingly complex set of mechanisms. Although the knowledge of its physiological function is largely limited to receptor trafficking in neurons, there is mounting evidence that LMTK3 promotes oncogenesis in a wide variety of cancers. Recent studies have broadened our understanding of LMTK3 and demonstrated its importance in numerous signalling pathways, culminating in the identification of a potent and selective LMTK3 inhibitor. Here, we review the roles of LMTK3 in health and disease and discuss how this research may be used to develop novel therapeutics to advance cancer treatment.
Species ecology explains the spatial components of genetic diversity in tropical reef fishes

Generating genomic data for 19 tropical reef fish species of the Western Indian Ocean, we investigate how species ecology influences genetic diversity patterns from local to regional scales. We distinguish between the α, β and γ components of genetic diversity, which we subsequently link to six ecological traits. We find that the α and γ components of genetic diversity are strongly correlated so that species with a high total regional genetic diversity display systematically high local diversity. The α and γ diversity components are negatively associated with species abundance recorded using underwater visual surveys and positively associated with body size. Pelagic larval duration is found to be negatively related to genetic β diversity supporting its role as a dispersal trait in marine fishes. Deviation from the neutral theory of molecular evolution motivates further effort to understand the processes shaping genetic diversity and ultimately the diversification of the exceptional diversity of tropical reef fishes.
COELOMIC STEATITIS IN TENTACLED SNAKES (ERPETON TENTACULATUM)

Abstract: A retrospective study revealed seven cases of coelomic steatitis in adult tentacled snakes (Erpeton tentaculatum), including two males and five females, between May 2014 and August 2020. Common clinical signs included death after unusual floating, generalized weakness, inappetence, reduced body condition, coelomic distension, and reproductive pathology in females. Hematology of one specimen revealed marked monocytosis and lymphocytosis with mild heterophilia (chronic and active inflammation). Gross examination identified variable degrees of intracoelomic fat necrosis in all snakes. Consistent histopathologic features included necrotic adipocytes, lipid saponification, lipofuscin/ceroid deposition, granulomatous inflammation, and multinucleated giant cells (Langhans type). Three females exhibited intralesional yolk fluid associated with periovarian steatitis. Hepatic lipidosis was the second most frequent pathologic finding. Thawed frozen lesser sand eels (Ammodytes tobianus) were fed during this period, stored in vacuum-sealed or opened packets at –18°C (frozen). After the death of the last specimen, vitamin E concentrations and peroxide values of the diet were analyzed. For the sealed and opened frozen batches, respectively, vitamin E concentrations were 0.71 and 0.49 mg/100 g (compared with 4 to 8 mg/100 g in average, fresh, raw mixed eel species samples) and peroxide values were 62.5 and 48.6 meq/kg (exceeding the acceptable peroxide values of 8 meq/kg for fish oils). This case study represents the first report of coelomic steatitis in tentacled snakes of unconfirmed etiology but with a putative association with feeding a long-term frozen-stored sand eel diet containing low vitamin E concentrations and fish oils with high peroxide values at time of analysis.
PREVALENCE AND ANTIMICROBIAL RESISTANCE PATTERNS OF SALMONELLA SPP. IN TWO FREE-RANGING POPULATIONS OF EASTERN BOX TURTLES (TERRAPENE CAROLINA CAROLINA)

Abstract: Salmonellosis is an important zoonotic infection, and exposure to pet reptiles has been implicated in several human outbreaks. Although several studies report a low prevalence of salmonellae in free-ranging chelonians, they may serve as a reservoir. In spring and summer of 2013 and 2019, free-ranging eastern box turtles (Terrapene carolina carolina) from populations in Illinois (rural) and Tennessee (urban) were collected through canine and visual search. Cloacal swab samples were collected from each turtle, selectively enriched with tetrathionate broth, then plated on selective and differential media to isolate Salmonella spp. Genus was confirmed via MALDI-TOF MS and antibiotic sensitivities were performed. Isolates were serotyped by the National Veterinary Services Laboratory. Of the 341 turtles sampled, Salmonella spp. were detected in nine individuals (2.64%; 95% CI: 1.2–5.0%). The isolates included five different serovars: Anatum (n = 2), Newport (n = 2), Thompson (n = 1), Bareilly (n = 2), and Hartford (n = 2). Salmonella spp. were detected from six animals in 2013 (3.19%, 95% CI: 1.2–6.8%) and three in 2019 (1.96%, 95% CI: 0.4–5.6%). There was no significant difference in prevalence between state, (P = 0.115), Illinois locations (P = 0.224), season (P = 0.525), year (P = 0.297), sex (P = 0.435), or age class (P = 0.549). The health of Salmonella-positive and -negative turtles was not significantly different, as assessed through hematology and plasma biochemistry (P > 0.05), indicating asymptomatic carrier status. The low prevalence detected in this study likely concludes that free-ranging eastern box turtles play a minimal role in the spread of salmonellae. However, the identified serotypes are potentially human- and animal-pathogenic. Documenting the prevalence of Salmonella serotypes in animal indicators furthers our understanding of their spread between humans, animal agriculture, and the environment.
A REVIEW OF MORTALITY IN TENTACLED SNAKES (ERPETON TENTACULATUM) IN A MULTI-INSTITUTION ZOOLOGICAL COLLECTION BETWEEN 1966 AND 2017

Abstract: The tentacled snake (Erpeton tentaculatum) is a viviparous aquatic snake that is a desirable species to exhibit in zoological collections because of its unique appearance and feeding strategies. Despite its presence in zoo collections over the past 50 yr, a comprehensive review of mortality and morbidity in the species has not been published. This study retrospectively reviewed 125 pathology reports from tentacled snakes in a multi-institution zoological collection in New York (The Wildlife Conservation Society's Bronx and Central Park zoos) between 1966 and 2017. Just over half of the deaths were due to infectious disease (n = 67; 53.6%), and of these, over half (n = 40; 59.7%) were due to fungal dermatitis. Fungal histomorphology was consistent with Paranannizziopsis spp. in most cases. Death due to bacterial infection was also relatively common (n = 21; 16.8%), and one-third had intralesional bacilli consistent with Mycobacterium spp. (n = 7; 5.6%). The most common comorbidities included gastrointestinal parasitism (n = 44; 35.2%), renal pathology (n = 31; 24.8%), and lipid accumulation of hepatocytes (n = 13; 10.4%). This retrospective review suggests that managing infectious diseases plays a role in the long-term care and survival of captive tentacled snakes.
Messenger RNA Expression of Albumin, Transferrin, Transthyretin, Asialoglycoprotein Receptor, Cytochrome P450 Isoform, Uptake Transporter, and Efflux Transporter Genes as a Function of Culture Duration in Prolonged Cultured Cryopreserved Human Hepatocytes as Collagen-Matrigel Sandwich Cultures: Evid

Hepatic gene expression as a function of culture duration was evaluated in prolonged cultured human hepatocytes. Human hepatocytes from seven donors were maintained as near-confluent collagen-Matrigelsandwich cultures, with messenger RNA expression for genes responsible for key hepatic functions quantified by real-time polymerase chain reaction at culture durations of 0 (day of plating), 2, 7, 9, 16, 23, 26, 29, 36, and 43 days. Key hepatocyte genes were evaluated, including the differentiation markers albumin, transferrin, and transthyretin; the hepatocyte-specific asialoglycoprotein receptor 1 cytochrome P450 isoforms CYP1A2, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP3A4, and CYP3A7; uptake transporter isoforms SLC10A1, SLC22A1, SLC22A7, SLCO1B1, SLCO1B3, and SLCO2B1; efflux transporter isoforms ATP binding cassette (ABC)B1, ABCB11, ABCC2, ABCC3, ABCC4, and ABCG2; and the nonspecific housekeeping gene hypoxanthine ribosyl transferase 1 (HPRT1). The well established dedifferentiation phenomenon was observed on day 2, with substantial (>80%) decreases in gene expression in day 2 cultures observed for all genes evaluated except HPRT1 and efflux transporters ABCB1, ABCC2, ABCC3 (<50% decrease in expression), ABCC4 (>400% increase in expression), and ABCG2 (no decrease in expression). All genes with a >80% decrease in expression were found to have increased levels of expression on day 7, with peak expression observed on either day 7 or day 9, followed by a gradual decrease in expression up to the longest duration evaluated of 43 days. Our results provide evidence that cultured human hepatocytes undergo redifferentiation upon prolonged culturing. SIGNIFICANCE STATEMENT This study reports that although human hepatocytes underwent dedifferentiation upon 2 days of culture, prolonged culturing resulted in redifferentiation based on gene expression of differentiation markers, uptake and efflux transporters, and cytochrome P450 isoforms. The observed redifferentiation suggests that prolonged (>7 days) culturing of human hepatocyte cultures may represent an experimental approach to overcome the initial dedifferentiation process, resulting in “stabilized” hepatocytes that can be applied toward the evaluation of drug properties requiring an extended period of treatment and evaluation.
An overview of young chemists’ expectations towards the sustainable development of the chemical sector. Opinions that matter

Abstract Young chemists play an important role in the transformation of the chemical sector in the next couple of years. They will have to do the heavy lifting and find the solutions needed for a sustainable tomorrow. Therefore, it is important to give them a voice in what their expectations are, how they believe they should be educated and prepared, and what opportunities they see for implementation levels in different areas to promote sustainable development. To shed light on these often under-represented opinions, young chemists across the globe were asked to express their views on the role and responsibilities of the chemical sector anonymously. The result is a snapshot of how young chemists perceive the future of chemistry and the immediate actions that need to be taken to get there. Throughout all answers, their hopes are expressed that the chemical sector will realize its great role and responsibility in leading and promoting sustainable development, thus limiting global warming, through cooperation with authorities, other sectors, and civil society. In this regard, young chemists do have numerous specific ideas about appropriate measures and are eager to take part in shaping a sustainable future.
Study Regarding the Development of Jumping Ability in Basketball Game

Abstract Modern basketball game is becoming more and more physical, and coaches have reoriented their view on building strong athletes with speed, strength, and accuracy. Jumping ability is used in many moves in basketball, from rebounding, defending, jump shoot, blocking till interception and offensive game. The vertical jump is the primary and essential skill in the jumping ability of a basketball player. Our research focused on the result of a questionnaire with 20 respondents that were coaches at different levels regarding the importance of vertical jump in the basketball game. The conclusions highlighted that vertical jump is considered necessary also for small players (point guard, shooting guard) and tall players (short forward, power forward, center), with emphasis on small players who have to compensate for their height with an excellent vertical jump; also the contribution of coordination and endurance, nutrition and appropriate rest periods can contribute decisively to the jumping ability. Also, between the methods of developing vertical jump was underlined the plyometric and circuit training.
Oil Price and Macroeconomic Fundamentals in African Net Oil-Exporting Countries: Evidence from Toda–Yamamoto and Homogeneous Causality Tests

Abstract Despite the wealth of literature on the oil price growth examinations, there is a shortage of research on the causality between oil prices and various macroeconomic fundamentals with regard to the group of net oil-exporting countries in Africa. This study examines the causality between oil price volatility and macroeconomic fundamentals in net oil-exporting countries in Africa using the Toda–Yamamoto and homogeneous causality techniques to gauge the nexus in the selected countries from 1995 to 2019. Our findings from the panel causality test suggest that oil price volatility significantly Granger causes the economic growth of the selected net oil-exporting countries in Africa. However, a mixed outcome was observed for the cross-sectional analyses using the Toda–Yamamoto causality test. Hence, the study offers the need for a policy framework that would drive the output growth as oil price changes continue to threaten macroeconomic variables.
Social Transparency in Rural Areas in Norway: Promoting or Restraining the Desire to Stay?

Abstract “Everyone knows everyone” is a recurring characteristic in descriptions of rural communities, one that has been interpreted as both a benefit and a drawback in research on such localities. In response to that discrepancy, this paper investigates the overall statistical effect of social transparency on residents’ desire to continue living in their rural communities. As revealed by analyses of survey data representing a national sample of Norway’s rural population in 2016, social transparency did significantly increase respondents’ desire to maintain residency in their rural communities. In providing and explaining such results, the paper contributes to current understandings of social conditions that influence rural (non-)migration and rural resilience.
Effect of corporate ethics and social responsibility on OCB: the role of employee identification and perceived CSR significance

Abstract The objective of this study is to examine the nature of the association that corporate ethics and CSR have with the two dimensions of organizational citizenship behavior (OCB), OCB toward other individuals in the company (OCBI) and OCB toward the organization’s strategies and objectives (OCBO). Based on a framework involving the resource-based view of the firm and the social identity theory, the CSR-OCB relationship is investigated with regard to employees’ perceived significance of CSR practices as well as their identification (association level) with the organization. The proposed model depicting the relationships is tested empirically based on data collected from a survey instrument distributed to alumni from one of the leading universities in Lebanon employed in various companies belonging to different sectors in Lebanon and the region. Partial least square structural equation modeling (PLS-SEM) is used to analyze the data and multi-group analysis is conducted to investigate the role of perceived CSR significance. Based on the data analysis results, the model is validated and the stated hypotheses are supported. Moreover, the moderating role of the perceived CSR significance in the relationship between CSR and OCB is highlighted. Theoretical and practical implications, study limitations, and further research recommendations are provided.
Employing industry experts as casual academics: value-adding or undervalued?

ABSTRACT Universities often employ industry experts in teaching roles to help bridge the theory – practice gap. As practitioners, they have the potential to make significant contributions to learning outcomes and to help prepare students for future employment. Using a case study approach based on qualitative data from the Business School in an Australian university, the study explores the reasons why industry experts take on an adjunct role, their experiences in that role, and the extent to which they perceive their contribution is valued within the university. The findings highlight the frustrations experienced by industry experts in their academic role. Participants were often frustrated by remuneration, lack of support, lack of communication and isolation from the wider university community. Drawing on human and social capital theory, the article shows how industry experts can add value by supporting students to develop their own human and social capital and by strengthening links between universities and industry. The paper concludes with suggestions for more effective people management practices ensuring that human and social capital contributions by industry experts are maximised for the benefit of all stakeholders.
Health and Employment Experiences of Chinese International Students in Australia

Abstract Chinese international students represent a significant social, economic and cultural force in Australian society. Research has demonstrated that Chinese students enrich Australia not only through their economic contribution, but through soft diplomacy and cultural links. Despite this, and the recent rapid growth in the number of Chinese international students to the country, only a small number of studies have focused specifically on understanding the health and employment experiences of Chinese students in Australia. This paper examines interview data from an ethnographic study involving ten Chinese international students pursuing higher education in New South Wales, Australia. Topics concerning work rights and exploitation, migration, and cultural differences are touched upon within their health and employment experiences. This paper provides insights for those working with Chinese international students in the areas of health education and promotion, diversity and inclusion, employment and mobility studies. The results contribute to broader insights into the inward/outward mobility of higher education students and Australia’s National Strategy for International Education 2025.
Intercultural competence as an important attribute for the graduates in the context of globalisation: the case of young Vietnamese working for INGOs

ABSTRACT Many workplaces in Vietnam, such as international non-government organisations (INGOs), where Vietnamese staff collaborate with people from different cultures, have become increasingly culturally diverse and interdisciplinary. This paper is based on the findings of broader qualitative research conducted between December 2010 and November 2012 that explored young Vietnamese graduates’ experiences of working at the intersection of different cultural worlds in the context of development projects at INGOs in Vietnam. Interviewees were nineteen young Vietnamese graduates and six international directors or deputy directors. This paper discusses their experiences of working for INGOs. Young graduates developed intercultural communication skills, became empathetic with others, and reconciled disparate cultural practices. While helping local communities adapt to development projects, graduates harmoniously combined the cultural values and customs of both sides. They disseminated information, promoted mutual understanding, formed culturally relativistic attitudes, promoted cross-cultural empathy, spread international goodwill and reconciled disparate cultural practices, facilitated communication, and interacted with persons or groups of different cultures.
Developing Critical Thinking: Experiences of Chinese International Students in a Post-1992 University in England

Abstract Critical thinking is a key attribute for students in British higher education, but there has been little research on how Chinese students develop critical thinking during their studies at British universities. Based on interviews with sixteen Chinese students at a university in England, this paper reports their experiences of developing critical thinking during their one-year Master’s programmes. Developing critical thinking was not always an easy task for these students. In addition to cultural background, other factors that played important roles in influencing how these students developed critical thinking included the teachers’ questioning approaches, group discussions in the classes, English language proficiency, and the criteria for assessing critical thinking in writing practices. The findings suggest that it is time to shift the ‘deficit’ conceptualization in which Chinese students are seen as lacking critical thinking and reexamine the ways that lecturers can facilitate the development of critical thinking of these students.
Differences in the concentrations of trace elements among different hard structures and their potential application in species identification: a case study on Loliginidae cryptic species

ABSTRACT It is a challenge to identify Uroteuthis chinensis and Uroteuthis edulis, which widely distributed in the coast of China, due to their morphological similarity. Trace elements in cephalopod hard structures may indicate species difference. In this study, with the laser ablation–inductively coupled plasma–mass spectrometry (LA-ICP-MS), we analysed trace elements in three kinds of hard structures (statolith, beak and eye lens), determined the differences in the concentrations of trace elements among different hard structures and identified U. chinensis and U. edulis caught from northern South China Sea with the determined elemental signatures in different ontogenetic stages. Nine elements were detected from the squid's statolith and beak, eight elements were detected from eye lens. Calcium (Ca) was the most abundant element in both statolith and beak, whereas phosphorus (P) was the most abundant element in eye lens. The significant differences in some trace elements were determined among different ontogenetic stages in both species. Discriminant analysis results showed that the correct classification rate based on trace elements in the late life stages (sub-adult and adult) was higher than that based on trace elements in the early life stages (embryonic, paralarval and juvenile). All three hard structures yielded a similar classification rate.