Miracle-dz/UniFAR-FTUs huggingface dataset:
The Effect of Global DNA Methylation on PDCD5 Expression in the PBMC of Occupational Chromate Exposed Workers

Supplemental Digital Content is available in the text Objectives: To evaluate the alteration of protein of programmed cell death 5 (PDCD5) in peripheral blood mononuclear cells (PBMC) and DNA methylation caused by hexavalent chromium exposure. Methods: There were 112 workers and 56 controls in this study. The chromium in RBC and urine, PBMC with PDCD5+, DNA methylation, urinary 8-hydroxy-2′-deoxyguanosine (8-OHdG) and score of DNA damage were measured. Results: In chromate exposed workers, the percent of PBMC with PDCD5+, urine 8-OHdG, and score of DNA damage were significantly higher, whereas global DNA methylation was significantly lower. The binary logistic regression and generalized linear mixed model analysis showed that the percent of PBMC with PDCD5+ was significantly associated with global DNA hypomethylation. Conclusions: The aberrant DNA hypomethylation plays an important role in PBMC apoptosis of occupational hexavalent chromium exposure.
Impact of multiphysics interactions on the gas flow performances in shale gas reservoirs

I TABLE OF CONTENTS . IV LIST OF TABLES . VIII LIST OF FIGURES . IX ACKNOWLEDGEMENTS . XIII PUBLICATIONS ARISING FROM THIS THESIS . XV STATEMENT OF CANDIDATE CONTRIBUTION (%) . XVI CHAPTER
How does business analytics contribute to organisational performance and business value? A resource-based view

PurposeThe purpose of this article is to identify how the organisations are able to improve their business value through acquisition of business analytics capabilities and by improving their performance.Design/methodology/approachWith the help of literature survey, along with standard resource-based view framework, a conceptual model has been developed. These have been statistically tested by collecting the data using the survey questionnaire from 306 selected respondents from various service sector- and product-based organisations in India. To analyse the data we have used partial least square–based structural equation modelling.FindingsThe study highlights that by the help of data acquisition and tool acquisition as two vital components the acquisition of business analytics capabilities could improve the business value of the organisation by strengthening its organisational performance. The findings of this research also indicated that acquisition of business analytics capabilities has a significant influence on an organisation's business process performance and business decision, which in turn significantly influences organisational performance. And organisational performance eventually positively influences its business value. The model was found to provide an explanative power of 71%. Research limitations/implicationsThe proposed research model can provide effective recommendations to the management of the organisations to realise the importance of acquisition of effective business analytics capabilities to eventually improve the business value of the organisation.Originality/valueNo specific studies, as yet, have analysed the effects of acquisition of business analytics capabilities for improving organisational performance mediated through business process performance and business decision. Therefore, this research has explored the distinctive effort to empirically validate this understanding.
An illustrated catalogue of the type specimens of Lepidoptera (Insecta) housed in the Zoological Museum Hamburg (ZMH): Part I. superfamilies Hepialoidea, Cossoidea, and Zygaenoidea

Zoological collections remain the main archive of animal biodiversity on Earth, and especially in times of large-scale declines of many groups represent important resources for biodiversity and conservation research. The most important individuals of these collections are the type specimens, which represent the original and unique reference for a species. While a full digitization of most museum collections currently remains utopic, lists of types are an essential resource for researchers to perform taxonomic revisions. Here, we provide an updated type catalogue of the lepidopteran superfamilies Hepialoidea, Cossoidea and Zygaenoidea deposited in the Zoological Museum of Hamburg (ZMH). In this paper, we report 259 specimens labelled as “types” belonging to 36 infrasubspecific taxa (invalid under the ICZN codes), 34 subspecies (16 of valid status) and 13 species (all of valid status). We present a full bibliography of the original descriptions and illustrations for all taxa, aiming to provide a comprehensive taxonomic guide to this collection.
THE IMPACT OF BEDTIME COMPULSIVE SOCIAL MEDIA USE ON STUDENTS’ QUALITY OF SLEEP IN THE COPPERBELT COLLEGES OF EDUCATION, ZAMBIA

This study investigated the relationship between bedtime Compulsive Social Media Use (CSMU) on students' sleep quality in the Copperbelt Colleges of Education, Zambia. Mixed method was utilised to solicit data from a sample of five hundred and seventy-nine (579) college students who were drawn from three (3) public and three (3) private colleges. Bergen Social Media Addiction Scale (BSMAS) and Pittsburgh Sleep Quality Index (PSQI) scale were utilised for data collection. Quantitative data were analysed using Statistical Package for the Social Science, whereas qualitative data was analysed using thematic analysis. Findings showed provision of pleasure as motive that compiled students to use social media during bedtime. Besides, it was established that students were spending less than 8 hours of sleep. However, the negative correlation between CSMU and sleep quality was evident. Therefore, the study recommends that college managements should conduct awareness programs to educate students on the negative effects of excessive usage of social media, particularly during bedtime.
Comparative Efficacy of Nonoperative Treatments for Greater Trochanteric Pain Syndrome: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials

Supplemental Digital Content is Available in the Text. Objective: An evolved understanding of the pathophysiology of greater trochanteric pain syndrome has led to a number of proposed nonoperative management strategies. The objective of this review was to compare the efficacy of the various nonoperative treatments for greater trochanteric pain syndrome (GTPS). Design: Systematic review and network meta-analysis. Setting: PubMed, Embase, CENTRAL, SCOPUS, and Web of Science were searched to January 2020. Patients: Patients undergoing nonoperative treatment for GTPS. Interventions: Nonoperative treatment strategies for GTPS including injections of corticosteroids, platelet-rich plasma, hyaluronic acid, dry needling, and structured exercise programs and extracorporeal shockwave therapy. Main Outcome Measures: Pain and functional outcomes. Bayesian random-effects model was performed to assess the direct and indirect comparison of all treatment options. Results: Thirteen randomized controlled trials and 1034 patients were included. For pain scores at 1 to 3 months follow-up, both platelet-rich plasma (PRP) and shockwave therapy demonstrated significantly better pain scores compared with the no treatment control group with PRP having the highest probability of being the best treatment at both 1 to 3 months and 6 to 12 months. No proposed therapies significantly outperformed the no treatment control group for pain scores at 6 to 12 months. Structured exercise had the highest probability of being the best treatment for improvements in functional outcomes and was the only treatment that significantly improved functional outcome scores compared with the no treatment arm at 1 to 3 months. Conclusion: Current evidence suggests that PRP and shockwave therapy may provide short-term (1-3 months) pain relief, and structured exercise leads to short-term (1-3 months) improvements in functional outcomes.
Utilizing the care coordination Atlas as a framework: An integrative review of transitional care models

Introduction Care coordination reduces care fragmentation and costs while improving health care quality. Transitional care programs, guided by tested models are an important component of effective care coordination, and have been found to reduce adverse events and prevent hospital readmissions. Using the Care Coordination Atlas as a framework, this article reports an integrative review of two transitional care models including analysis of model components, implementation factors, and associated 30-day all-cause hospital readmission rates. Methods Integrative review methodology. PubMed and Scopus databases were searched from January 2015 to July 2020. Fourteen studies set in 18 skilled nursing facilities and 50 hospitals were selected for data extraction and analysis. Results The ReEngineered Discharge model had five components and the Better Outcomes by Optimizing Safe Transitions model had eight components in the nine Care Coordination Atlas domains. Communication dominated activities in both models while neither addressed accountability/responsibility. Implementation was influenced by leadership commitment to understanding complexity of the models, culture change, integration of models into workflows, and associated labor costs. Model implementation studies consistently reported improvements in facilities’ 30-day all-cause hospital readmission rates. Discussion The Care Coordination Atlas was a useful framework to guide analysis of transitional care models. Leadership commitment to and participation in model implementation is vital. The models do not focus beyond the immediate post-discharge period limiting the impact on chronic disease management. Frameworks such as the Care Coordination Atlas are useful to help guide development of care coordination activities and associations with readmission rates.
Clubroot resistance in canola and brassica vegetable cultivars in Ontario, Canada

Abstract: Clubroot, caused by the obligate pathogen Plasmodiophora brassicae Woronin, has been present on brassica vegetables in Ontario for decades, but was only recently identified on canola (Brassica napus L.). Once P. brassicae is present in a field, eradication is difficult, but resistant cultivars can provide effective management. Pathotype 6 has been the predominant pathotype on vegetable crops for decades, but pathotype 2 is predominant in canola fields in Ontario. Field trials were used to assess the reaction of selected canola and vegetable Brassica cultivars to pathotype 2, and controlled environment studies were conducted to evaluate the reaction of the same cultivars to pathotypes 2 and 6. Four canola cultivars with putative clubroot resistance were compared with two cultivars that were expected to be susceptible and three susceptible control cultivars. Several brassica vegetables were assessed: cabbage, cauliflower, broccoli, napa cabbage, rutabaga, and Shanghai pak choi (a susceptible control). The canola cultivars marketed as resistant were highly resistant in both the field and growth room trials. The canola cultivars not marketed as resistant were susceptible to pathotype 2, as expected. All of the canola cultivars were resistant to pathotype 6. The vegetable cultivars marketed as resistant or tolerant were resistant to pathotype 6 and most were resistant to pathotype 2. A putative resistant cultivar of cabbage and one of broccoli were resistant to pathotype 6 but susceptible to pathotype 2. Clubroot consistently reduced fresh shoot weight in susceptible cultivars of canola and brassica vegetables relative to resistant cultivars.
A Model for Coupled Belousov-Zhabotinsky Oscillators with Delay

Abstract. The purpose of this work is to introduce time delays in an Oregonator-based model [11] to describe molecular communication in a system of coupled chemical oscillators [5]. With this approach we assume that the molecules responsible for communication (signal molecules) take a non-zero time τ to cross the barrier (phospholipid membrane) which physically separate the oscillators. In particular, here we present numerical results and we discuss and highlight the differences between delayed and non-delayed models.
Has the COVID-19 Pandemic Affected Maritime Connectivity? An Estimation for China and the Polar Silk Road Countries

In light of about 80% of international freight traffic carried by sea, maritime supply chains’ stability is pivotal to global connectivity. For over a year now, the transboundary mobility of vessels and cargoes has been restricted by diverse forms of the COVID-19 containment measures applied by national governments, while the lockdowns of people, businesses, and economic activities have significantly affected the growth prospects of various maritime connectivity initiatives. This study investigates how the pandemic-related public health, trade, and market factors have shifted the connectivity patterns in the Polar Silk Road (PSR) transport corridor between China, South Korea, Japan, Russia, and four economies of Northern Europe. The causality links between the Shipping Connectivity Index (SCI) and the number of COVID-19 cases and deaths, trade volumes with China and the rest of the world, and price indexes of minerals, fuels, food, and agricultural products are revealed separately for eight countries and thirty-five ports. The study algorithm is built on the consecutive application of the Augmented Dickey-Fuller (ADF) and the Phillips-Perron (PP) stationarity tests, the Autoregressive Distributed Lag (ARDL) method, the Fully-Modified Ordinary Least Squares (FMOLS) and the Dynamic Ordinary Least Squares (DOLS) robustness checks, and the Toda-Yamamoto causality test. Tight trade-connectivity links are recorded in all locations along the China-PSR transport corridor in 2015–2019, but in 2020, the relationships weakened. Bidirectional influences between the number of COVID-19 cases and connectivity parameters demonstrate the maritime sector’s sensitivity to safety regulations and bring into focus the role of cargo shipping in the transboundary spread of the virus. The authors’ four-stage approach contributes to the establishment of a methodology framework that may equip stakeholders with insights about potential risks to maritime connectivity in the China-PSR maritime trade in the course of the pandemic.
Influence of Ceramic Lumineers on Inflammatory Periodontal Parameters and Gingival Crevicular Fluid IL-6 and TNF-α Levels—A Clinical Trial

The aim was to evaluate the effect of ceramic lumineers on inflammatory periodontal parameters, gingival crevicular fluid (GCF) flow rate and cytokine profile. Patients were provided with lumineers using standardized technique including minimal to no preparation. Ceramic lumineers were etched with hydrofluoric acid and teeth with phosphoric acid followed by adhesive cementation. Periodontal parameters (Plaque index (PI), bleeding on probing (BOP), periodontal pocket depth (PPD), and clinical attachment loss (CAL)) were recorded at baseline and after 4, 12, and 24 weeks of lumineer cementation. Assessment of GCF flow rate and levels of IL-6 and TNF-α was made using enzyme linked immunosorbent assay (ELISA). The statistical significance was determined by the t-test, analysis of variance and post hoc Tukey’s test. It was found that PI, BOP, PPD, and CAL at baseline and 24 weeks were comparable (p > 0.05). The GCF volume at baseline was comparable to the GCF at week 24 (p > 0.05). The IL-6 levels at baseline (5.4 ± 3.6) were similar to those at 24 week (7.4 ± 5.2) (p > 0.05). The TNF-α at week 4 (65.3 ± 16.2), 12 (25 ± 10.2), and 24 (21.3 ± 7.6) was higher than the baseline (13.7 ± 5.8) (p < 0.05). Clinical periodontal parameters and GCF volume among patients treated with ceramic lumineers at baseline and twenty-four week follow-up were comparable. The GCF TNF-α levels significantly increased after ceramic lumineer cementation at 24-week follow-up.
High-Pressure Injection Injuries to the Foot: A Case Report of 2 Patients

Background: High-pressure injections injuries to the extremities can result in significant disability, including amputation of the affected limb. Proprietary mixtures associated with drill mud and hydraulic fracking leads to frequent encounters with varied materials. The physician needs to be aware of the effect of these materials when inadvertent exposure occurs. Injected toxic materials cause extensive soft tissue inflammation and destruction. This puts the foot at risk not only to the cleaning fluid used, generally water, but any contaminant on the boot at the time of injury. This case report is the first known case report involving injection with drill mud contaminant and describes 2 oil field injuries resulting in the gross deep contamination of the foot from a high-pressure washer injury. Case Report: Two patients, a 46-year-old man (patient 1) and a 29-year-old man (patient 2) sustained high-pressure injection injuries to the foot. These patients underwent treatment with immediate broad-spectrum antibiotics and emergent irrigation and debridement on arrival to the treating facility. Neither patient underwent amputation of the affected extremity as a result of their injuries and achieved a full recovery and return to work. Conclusion: High-pressure injection injuries are operative emergencies. Treatment should include tetanus prophylaxis, neurovascular monitoring, broad-spectrum antibiotic coverage, emergent operative debridement for toxic materials. Despite the toxic nature of the injection injuries, aggressive treatment can improve the chance of salvage in these industrial injuries.
Values and Valuing Across Cultures and Time Zones

Highlights Values and valuing are seen as enhancing pedagogical actions. Throughout the papers, the review of the literature is complemented and each research includes specific theoretical constructs. Regarding research methods, quantitative comparative research projects, which explore students’ values related to mathematics, have been influencing other research about values. A broad and shared theme by the group is the observation of the educational phenomena from a perspective that acknowledges culture and the humanness of the mathematical knowledge. In their research, the collective of authors truly incorporates humaneness in the production and in the teaching and learning of mathematics.
Lower-Extremity Intra-Joint Coordination and Its Variability between Fallers and Non-Fallers during Gait

Falling is one of the most common causes of hip fracture and death in older adults. A comparison of the biomechanics of the gait in fallers and non-fallers older adults, especially joint coordination and coordination variability, enables the understanding of mechanisms that underpin falling. Therefore, we compared lower-extremity intra-joint coordination and its variability between fallers and non-fallers older adults during gait. A total of 26 older adults, comprising 13 fallers, took part in this study. The participants walked barefoot at a self-selected speed on a 10-m walkway. Gait kinematics in the dominant leg during 10 cycles were captured with 10 motion tracking cameras at a sampling rate of 100 Hz. Spatiotemporal gait parameters, namely, cadence, walking speed, double support time, stride time, width, and length, as well as intra-joint coordination and coordination variability in the sagittal plane were compared between the two groups. Results showed that fallers walked with significant lower cadence, walking speed, and stride length but greater double support and stride time than non-fallers. Significant differences in the ankle-to-knee, knee-to-hip, and ankle-to-hip coordination patterns between fallers and non-fallers and less coordination variability in fallers compared to non-fallers in some instants of the gait cycles were observed. The differences in spatiotemporal gait parameters in fallers compared to non-fallers may indicate an adaptation resulting from decreased efficiency to decrease the risk of falling. Moreover, the differences in segment coordination and its variability may indicate an inconsistency in neuromuscular control. It may also indicate reduced ability to control the motion of the leg in preparation for foot contact with the ground and the knee and ankle motions during loading response. Finally, such differences may show less control in generating power during the push-off phase in fallers.
Corporate Governance, Audit Quality, Family Ownership and Earnings Management

This study aimed to obtain empirical evidence regarding the influence of corporate governance and audit quality on earnings management measures, as well as their relationship with the effect of family ownership. Research on earnings management has been widely conducted, but research in family firms is still limited, while based on previous observational data, 95% of companies in Indonesia are family firms. In addition, the difference in the concept of corporate governance in developing countries compared to developed countries is crucial in relation to company supervision patterns. Earnings management practices carried out by company management can be caused by the occurrence of information asymmetry in which management as an agent has more information related to the company than the company owner. This information asymmetry is used by managers to mislead other parties with the aim of increasing their managerial career or compensation. Implementing the corporate governance mechanism is a way to reduce earnings management. Another factor affecting earnings quality is audit quality. This study took a sample of manufacturing companies listed on the Indonesian Stock Exchange during the 2017- 2018 period. 152 sample data were tested. This study used secondary data obtained from annual reports of companies listed on the Indonesian Stock Exchange. Moderated regression analysis (MRA) was used. Corporate governance had no effect on earnings management and audit quality had a significant effect on earnings management behavior. Family ownership was able to strengthen the effect of audit quality in determining earnings management actions. Keywords: corporate governance, audit quality, earnings management, family ownership
Learning Pediatric Point-of-Care Ultrasound

Supplemental digital content is available in the text. Objectives Using an education and assessment tool, we examined the number of cases necessary to achieve a performance benchmark in image interpretation of pediatric soft tissue, cardiac, lung, and focused assessment with sonography for trauma (FAST) point-of-care ultrasound (POCUS) applications. We also determined interpretation difficulty scores to derive which cases provided the greatest diagnostic challenges. Methods Pediatric emergency physicians participated in web-based pediatric POCUS courses sponsored by their institution as a credentialing priority. Participants deliberately practiced cases until they achieved diagnostic interpretation scores of combined 90% accuracy, sensitivity, and specificity. Results Of the 463 who enrolled, 379 (81.9%) completed cases. The median (interquartile range) number of cases required to achieve the performance benchmark for soft tissue was 94 (68–128); cardiac, 128 (86–201); lung, 87 (25–118); and FAST, 93 (68–133) (P < 0001). Specifically, cases completed to achieve benchmark were higher for cardiac relative to other applications (P < 0.0001 for all comparisons). In soft tissue cases, a foreign body was more difficult to diagnose than cobblestoning and hypoechoic collections (P = 0.036). Poor cardiac function and abnormal ventricles were more difficult to interpret with accuracy than normal (P < 0.0001) or pericardial effusion cases (P = 0.01). The absence of lung sliding was significantly more difficult to interpret than normal lung cases (P = 0.028). The interpretation difficulty of various FAST imaging findings was not significantly different. Conclusions There was a significant variation in number of cases required to reach a performance benchmark. We also identified the specific applications and imaging findings that demonstrated the greatest diagnostic challenges. These data may inform future credentialing guidelines and POCUS learning interventions.