Miracle-dz/UniFAR-FTUs huggingface dataset:
A meta-analysis

Hypoxia-inducible factor-1 (HIF-1), an important component of angiogenesis, is activated as a response to tumor hypoxia and facilitates tumor survival. Several case–control articles stressed the connection between lung cancer danger and HIF-1a gene polymorphism, but the conclusions were conflicting. Thus, this meta-analysis was carried out to assess the connection between HIF-1a gene polymorphisms (rs11549467, rs11549465, and rs2057482) and lung cancer risk. PubMed, Embase, Cochrane Library, and Google Scholar were systematically searched up to November 1, 2018. The study quality was quantified by the c. The odds ratios (ORs) and 95% confidence intervals (CIs) were pooled in 5 genetic models for assessment under a fixedor random-effect model. Subgroup analyses were carried out by ethnicity and genotype method. Sensitivity analysis and publication bias were tested. Five eligible articles were enrolled. The rs11549467 significantly increased the lung cancer risk (OR [95% CI]: A vs G, 1.68 [1.03–2.76]; AA + AG vs GG, 1.70 [1.14– 2.54]; AA vs GG, 1.59 [1.21–2.10]), whereas neither rs11549465 nor rs2057482 was related with the lung cancer risk. Subgroup analysis showed rs11549465 and rs11549467 increased lung cancer risk among Asians, but not whites. HIF-1a rs2057482 was unrelated to the risk of lung cancer in Asians and whites. HIF-1a gene rs11549465 and rs11549467, but not rs2057482, increased the risk of lung cancer among Asians. Abbreviations: CI = confdence interval, HIF-1a = hypoxia-inducible factor-1a, HWE = Hardy–Weinberg equilibrium, NOS = Newcastle–Ottawa Scale, OR = odds ratio, SNP = single-nucleotide polymorphism.
A meta-analysis

Background: Laparoscopic right hepatectomy (LRH) is one of the most challenging procedures. Right liver resections have been always performed in open procedure and open right hepatectomy (ORH) was initially considered as routine way. Moreover, it is unclear how beneficial the minimally invasive technique is to patients; thus, we conducted a meta-analysis to acquire a more reliable conclusion about the feasibility and safety of LRH compared with ORH. Methods:We comprehensively searched the electronic databases of PubMed, Embase, and the Cochrane Library using the key words. Meta-analysis was performed using the ReviewManager, with results expressed as odds ratio and weighted mean difference with 95% confidence intervals. The fixed-effect model was selected initially if high heterogeneity was not present between the studies; otherwise, the randomized-effect model was used. Subgroup analysis was performed based on different surgical methods of pure laparoscopic operation or hand-assisted operation. Results: Seven studies with 467 patients were included. In the overall analysis, less intraoperative blood loss (MD=–155.17; 95% CI, –238.89, –71.45; P= .0003) and a shorter length of stay (MD=–4.45; 95% CI, –5.84, –3.07; P< .00001) were observed in the LRH group compared to the ORH group. There were fewer overall complications (OR=0.30; 95% CI, 0.10, 0.90; P=0.03) and severe complications (OR=0.24; 95% CI, 0.10, 0.58; P= .002;) in the LRH group than in the ORH group. The disadvantage of LRH was the longer operative time (MD=49.39; 95% CI, 5.33, 93.45; P= .03). No significant difference was observed between the 2 groups in portal occlusion, rate of R0 resection, transfusion rate, mild complications, and postoperative mortality. In the subgroup analysis, intraoperative blood loss was significantly lower in the pure LRH group and hand-assist LRH group compared with ORH group. Length of stay was shorter by use of pure LRH and hand-assisted LRH manners than ORH. The incidence rate of complications was lower in the pure LRH group than in the ORH group. In contrast, there was no significant difference between handassisted LRH group and ORH group. Conclusion:Compared to ORH, LRH has short-term surgical advantages and leads to a shorter recovery time in selected patients. We speculate that the operative time of LRH is closer with ORH. Overall, LRH can be considered a feasible choice in routine clinical practice with experienced surgeons, although more evidence is needed to make a definitive conclusion. Abbreviations: CIs = confidence intervals, FDR = false discovery rate, LOS = length of stay, LRH = laparoscopic right hepatectomy, OR = odds ratio, ORH = open right hepatectomy, RCT = randomized controlled trials, WMDs = weighted mean differences.
A meta-analysis

Objective: To explore whether rs4784227 polymorphism of CASC16 is correlated with risk of breast cancer. Methods: Relevant studies up to December 24, 2020 were searched in PubMed, Embase, Web of Science, CNKI, VIP, and WANFANG databases. Data were analyzed by using Stata 12.0. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated, and country-based subgroup analyses were conducted. Sensitivity analysis was conducted to assess the stability of the results. Publication bias was assessed by using the Egger regression asymmetry test and visualization of funnel plots. Results: Seven case-control studies enrolling 4055 breast cancer cases and 4229 controls were included. rs4784227 was found significantly associated with increased risk of breast cancer in a dominant (OR=1.301, 95%CI=1.190–1.423, P< .001), a recessive (OR=1.431, 95% CI=1.216–1.685, P< .001), and an allele model (OR=1.257, 95% CI=1.172–1.348, P< .001), while an overdominant model showed that rs4784227 was correlated with decreased breast cancer risk (OR=0.852, 95% CI=0.778–0.933, P= .001). Conclusion: The rs4784227 polymorphism of CASC16 gene is correlated with breast cancer susceptibility. Abbreviations: FOXA1 = forkhead box O1, TOX3 = TOX high-mobility box protein group family member 3.
A meta-analysis

Theobjective of this review is to systematically evaluate the short-termefficacy ofmud therapy in the treatment of knee osteoarthritis (KOA). Randomized controlled trials, in which treatment of KOA is mud therapy, were included by systematically searching the PubMed, Embase, and the Cochrane Library databases. According to inclusion criteria and searching method, 11 articles, containing a total of 1106 patients, were included in the study. Our results showed significant differences in visual analog scale pain score and Western Ontario and McMaster Universities Osteoarthritis Index (pain, stiffness, function). In addition, the heterogeneity of study included is lower (I<25%). According to the results of this meta-analysis, mud therapy can effectively alleviate the pain and improve joint function for KOA. Abbreviations: KOA = knee osteoarthritis, RCT = randomized controlled trial, VAS = visual analog scale, WOMAC = Western Ontario and McMaster Universities.
Cross-cultural adaptation and psychometric testing of the Arabic version of the Modified Low Back Pain Disability Questionnaire

Background The Modified Low Back Pain Disability Questionnaire (MLBPDQ) is used for evaluating the functional disability in patients with low back pain (LBP). However, the measurement characteristics of the MLBPDQ among Arab patients are unknown. In this study, we aimed to translate and cross-culturally adapt the MLBPDQ into Arabic and evaluate its psychometric properties. An Arabic version of the MLBPDQ was developed through forward translation, translation synthesis, and backward translation. Sixty-eight patients (55 males and 13 females) with a mean age 37.01 Aˆ 7.57 years were recruited to assess its psychometric properties. Reliability was evaluated using internal consistency (Cronbachaˆs Iˆ), test retest reliability (utilizing intraclass correlation coefficient [ICC]), standard error of measurement (SEM), minimal detectable change at 95% confidence level (MDC 95% ), and 95% limits of agreement (LOA). The construct validity was investigated by correlating the new translation with four other measures of LBP (using Spearmanaˆs rho). Finally, receiver operating characteristic curve was constructed to compute the sensitivity, using the area under the curve (AUC), and the minimum important change (MIC). An alpha level of 0.05 was set for statistical tests and all the psychometric values were tested against a priori hypotheses. The Arabic version of the MLBPDQ demonstrates adequate psychometric properties and can be used to assess disability level in patients with LBP in Arabic-speaking communities.
Integrated weed management and its effect on the seed cotton yield in cotton (Gossypium hirsutum L.) crop.

Integrated weed control comprising the use of herbicide and cultural operation was carried out against major weed communities belonging to broad leaf, narrow leaf and sedges infested in cotton crop during the year 2004-05 at the Plant Protection Institute, Faisalabad. The treatments viz., Stomp 455 G/L CS @ 1.875 L ha1 at pre-emergence of crop, Grip-up 48% SL @ 3.00 L ha1 as post-em at 45 days, Two Hoeing (25 and 45 days after crop emergence), Stomp 455 G/L CS @ 1.875 L ha1 at pre-em + Grip-up 48% SL @ 3.00 L ha1 as post-em at 45 days, Stomp 455 G/L CS @ 1.875 L ha1 at pre-em + Hoeing at 45 days after crop emergence and Hoeing at 25 days of crop emergence + Grip-up 48% SL @ 3.00 L ha1 as post-em at 45 days were compared with the untreated check (UTC). The best weed control of 96.8 % was recorded in the integration of the pre and post-em herbicide treatment of Stomp 455 G/L CS and Grip-up 48% followed by Grip-up 48% with 90.25% weed control as compared with the UTC. The lowest weed control of 74.14% was recorded from Two Hoeings. As a consequence of the weed control, the highest seed cotton yield of 2671 kg ha1 was obtained from integrated treatment of pre and post-em application of Stomp 455 G/L CS and Grip-up 48% SL followed by the integrated treatment of Hoeing and Grip-up 48% SL with 2629 kg ha1 yield. All other treatments although comparatively gave lower performance towards weed control and seed cotton yield, but were significantly better than UTC which produced the lowest yield of 1932 kg ha1 because of weed suppression. Results showed that all the weed control measures were effective and enhanced the seed cotton yield from 22.98 to 38.25 % over UTC. The study concluded that integrated weed management in cotton crop can significantly reduced the weed infestation and improve the seed cotton yield.
UvA-DARE ( Digital Academic Repository ) Advances in diagnosis and treatment of cerebral arterial gas embolism

Disclaimer/Complaints regulations If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. Please Ask the Library: https://uba.uva. nl/en/contact, or a letter to: Library of the University of Amsterdam, Secretariat, Singel 425, 1012 WP Amsterdam, The Netherlands. You will be contacted as soon as possible.
Landscape template of New York City's drinking-water-supply watersheds

Abstract New York City (NYC) receives >99% of its drinking-water supply from streams, rivers, and reservoirs north and northwest of the city (east or west of Hudson River [EOH or WOH, respectively]). As part of a large-scale enhanced water-quality monitoring project (the Project) in NYC's drinking-water-supply watersheds, 60 stream and 8 reservoir sampling sites were established in the water-supply area (30 WOH and 30 EOH) and sampled from 2000 to 2002. Our study describes watershed characteristics (including climate and hydrology, land use, human population, and known point-source discharges) at each study site and provides an analysis of differences in land use quantified at 3 scales: 1) watershed, 2) riparian (30 m on each side of entire stream network upstream of a site), and 3) reach (same as riparian, but truncated 1 km upstream of the study site). Regression analysis was used to determine relationships among scales, and principal components analysis was used to describe spatial differences in watershed characteristics across the study region. EOH sites are on smaller streams than WOH sites because the WOH region is much larger than the EOH region. EOH sites had smaller mean annual area-specific discharges than WOH sites, reflecting differences in precipitation and in watershed hydrologic retention that were related to surficial geology and the presence of wetlands, lakes, and reservoirs. Population densities, point-source discharges, and flows from those discharges were higher in EOH watersheds than in WOH watersheds. Landuse values in the EOH watersheds ranged from 87% forest to 57% urban. Agricultural land use exceeded 16% in only one watershed. Landuse values in WOH watersheds indicated either largely forest (several sites near 98%) or agriculture and grassland (many near 25%, largely in pasture). Urban landuse values were never >11%. Values for most landuse categories were strongly correlated (most R2 > 0.75) between the watershed and riparian scales. In WOH watersheds, values for categories indicating human land use (e.g., agriculture, urban) were greater at the riparian than at the watershed scale, indicating that human land use was concentrated along the stream network. In EOH watersheds, values for categories indicating human land use were lower at the riparian than at the watershed scale. Values for most landuse categories were not correlated (typically R2 < 0.50 or not significant) between the reach and watershed scales, indicating that local landuse values described statistically different conditions than watershed- or riparian-scale landuse values.
The Relationship Between Environmental Technology Patenting and Environmental Performance Index in Countries: What Does It Mean and How Can We Measure It

National governments need to make informed decisions to ensure sustainable development and the use of new technologies. Thus, two major problems emerge: how to evaluate governments’ success in encouraging companies to invest in environmental technologies, and how to measure the efficiency of technology diffusion in terms of environmental well-being. The knowledge about the relationship between environmental performance and environmental technologies at the country level enables decision-makers in the field of sustainable development to more rationally plan the costs of developing new technologies, as well as track the return on their implementation. As a result, society and industry will receive signals about the effectiveness of the implemented sustainable development policy. The main goal of the research was to overcome the gap in the field of environmental wellbeing: how to measure at the macro level the dependence of countries’ success in environmental performance on how developed they are in environmental technologies. The specific objective of the study was to quantify the relationship between the integral indicator of environmental well-being Environmental Performance Index (EPI) and innovative activity in the field of environmental technology at the cross-country level. To evaluate the development of environmental technologies, the platform solution Orbit Intelligence was used, specifically, the FamPat worldwide patent database. It was confirmed that the more developed the economy, the higher EPI and the level of development of environmental technology. At the same time, no relationship was found between the 10-year change in EPI and the 10-year change in the patent activity index. The hypothesis about the statistical significance of the relationship between the integral indicators of patent activity in the field of environmental technology and the current value of EPI was confirmed. A regression dependence was determined, which was well approximated by the linear regression of EPI on the logarithm of the country’s patent activity index in the field of environmental technology. The dependence can be interpreted as a slowdown in the growth of EPI when a certain level of patenting is reached. The novelty of the research lies in the fact that a framework has been proposed and implemented for assessing the relationship between environmental well-being and environmental technology. This framework can be used to study individual environmental problems in countries in more detail and to identify the level of available technologies for solving these problems.
Temporal Variation in the Hydrobiology of Vembanad Lake at Panangad- Kumbalam Mangrove Patches of Kochi, Kerala

The present investigation scrutinized the hydrobiological status of Vembanad Lake at Panangad-Kumbalam mangrove patches of Kochi. Distinct variations of hydrographic state and its influence on zooplankton abundance were observed. Study area revealed presence of 13 mangrove species belonging to 7 family and 9 genera. Salinity showed wide fluctuation (1.70‰ to 30.5‰). Average salinity was 19.74‰ indicated mesohaline nature. The average annual temperature was comparatively normal (28.94°C). Transparency showed lowest value during July (39.3 cm). The average pH during the study period was (7.38) on alkaline side. Dissolved oxygen was high (7.7 mg/l) during October compared March (3.9 mg/l). The average alkalinity was 95.83 mg/l. Nitrate values ranged from 2.40 µg/l to 35.90 µg/l. The phosphate value ranged between 0.90 µg/l and 9.0 µg/l with an average of 3.0 µg/l. Primary productivity showed an average of 1337.08 mg C/m 3 /day productive nature indicated backwater. Total number of copepods ranged from 2013 numbers/m 3 to 5347 numbers/m 3 . Total number of cladocerans ranged from 8 numbers/m 3 to 471 numbers/m 3 . Total number of rotifers ranged from 306 numbers/m 3 to 1263 numbers/m 3 . Onset of monsoon appeared to be major factor influencing the hydrography,
Needs of Farmers for Guidance Publication to the Development of Agricultural Extension in Anbar, Iraq

Guidance publication one of the most important sources of information for farmers about crop techniques,knowledge, and cropping information to get high productivity. Targeted research to asses the relationship between the wheat grower information level and recommendations of the Scientific pamphlet of wheat and some independent variables studied, as well as identify social characteristics, and functional for extension workers, and determine the reasons for non-use of the indicative releases from the point of view of agricultural workers. Iraq determines the research community in all extension agents to maintain a (92 Advisor) and sample farmer b (145 farms) of village farmers discussed (414) farms, selected a random sample of 35% of the province's villages and all of the following villages: ( Qusaiba village, Parwana and sons Hassan and corner Walnhih , Znkorh and the village of Black Hill). Data were collected by personal interview from 3 January to 28 March 2014 through the resolution, analysis of research data on the frequencies, percentages and arithmetic mean, standard deviation, range, as any simple correlation coefficient. The most significant results show that (18.6%) are small and that the information category (31, 7%), them with the information medium, and that (49.6%) They are with high information. Moral relationship at 0.01 level (0.05) between the level of agricultural information and (Gender, age, cultural openness, sources of information), and non-moral moral level 0, 05 for each of the following independent variables (marital status, Farming, engagement, agricultural property type, participate in outreach activities, the trend towards agricultural innovations). Keywords : Guidance Publication, Farmers, Field crops, Agricultural Extension, and Iraq.
Regulation of matrix metalloproteinases ( MMPs ) and their tissue inhibitors in human myometrial smooth muscle cells by TGF-β 1

The objective of the present study was to determine whether transforming growth factor β (TGF-β) regulates the expression of matrix metalloproteinases (MMP) and the tissue inhibitor of MMP (TIMP) in myometrial smooth muscle cells. Using primary cultures of human myometrial smooth muscle cells we found that these cells express MMP-1, MMP-3, TIMP-1 and TIMP-2 mRNA and protein, with significantly higher values of TIMP than MMP. We also found that TGF-β1 (1 ng/ml) increased the expression of TIMP-1 mRNA, while it reduced the expression of MMP-1 and MMP-3 mRNA, compared with untreated controls. In addition, TGF-β1 slightly increased the production of TIMP-1, but not TIMP-2. Production of MMP-1 and MMP-3 was reduced by treatment with TGF-β1, compared with the untreated control. A major portion of MMP-1 released into the culture-conditioned media was in complex with TIMP-1, and the levels of this complex were reduced by treatment with TGF-β1. In conclusion, the data indicate that myometrial smooth muscle cells express MMP and TIMP mRNA and protein, and their expression is differentially regulated by TGF-β1. Such a differential regulation of MMP and TIMP by TGF-β may influence the rate of extracellular matrix (ECM) turnover following tissue injury, induced during myomectomy and Caesarean section, or in leiomyomas during growth.
Derivation and verification of soil hydrodynamic parameters in cinnamon soil

Soil dynamic parameters are essential in guiding agriculture production,engineering design for soil and water conservation and irrigation works.In this paper,RETC software is used to deduce the soil water retention equations and soil hydraulic conductivity of van Genuchten model based on soil mechanical composition and bulk density in cinnamon soil.The soil specific water capacities are obtained form differential coefficients of the equations for soil water retention.The result is verified by field measurement using EQ15 equilibrium tensiometers and Trime-IT soil moisture sensors.It is concluded that the relative error of soil water retention is less than 10% and that of soil hydraulic conductivity is in the range of 18%～39%,both of them tends to decrease with the decrease of soil water potential.Therefore,it is feasible to use RETC software to derive soil hydrodynamic parameters.
Themed Issue : Resurrection of old antibiotics Old antibiotics for emerging multidrug-resistant / extensively drug-resistant tuberculosis ( MDR / XDR-TB )

Recently, multidrug-resistant tuberculosis (MDR-TB) has become a therapeutic challenge. In addition to drug resistance, drug adverse events, intravenous delivery, cost and availability of some antibiotics in low-income countries have led to a look back to old drugs, especially those efficient against closely related organisms such as Mycobacterium leprae. Here we review the available drugs that respect the conditions above and could be upgraded to first-line therapy for treating MDR-TB and extensively drugresistant tuberculosis (XDR-TB). © 2017 Published by Elsevier B.V.
THEMED ISSUE: CANNABINOIDS RESEARCH PAPER A cannabinoid receptor, sensitive to O-1918, is involved in the delayed hypotension induced by anandamide in anaesthetized rats

-3-[2-hydroxy-4-(1,1-dimethylheptyl)phenyl]-trans-4-(3-hydroxypropyl)cyclohexanol; DBP, diastolic blood pressure; DMSO, dimethyl sulphoxide; HR, heart rate; MBF, mesentericblood ﬂow; MBP, mean blood pressure; O-1918, 1,3-dimethoxy-5-2-[(1R,6R)-3-methyl-6-(1-methylethenyl)-2-cyclohexen-1-yl]-benzene; RBF, renal blood ﬂow; SBP, systolic blood pressure
Genome Sequence of Azotobacter vinelandii , an Obligate Aerobe Specialized To Support Diverse Anaerobic Metabolic Processes †

Published Ahead of Print 8 May 2009. 2009, 191(14):4534. DOI: 10.1128/JB.00504-09. J. Bacteriol. Ray Dixon and Derek Wood Baomin Wang, Cathy Wheeler, Huijun Zhu, Dennis R. Dean, David J. Studholme, Jian Sun, Carlos J. Viana, Erik Wallin, Rosser, Daniel Segura, Steve Slater, Shawn L. Stricklin, Ian Paulsen, Estella C. Raulfs, Rebecca Roemer, James Mali Mærk, Nancy M. Miller, Stacie Norton, Ina P. O'Carroll, Timothy J. Larson, Phil Latreille, Lauren S. Ligon, Jing Lu, Katherine Houmiel, Juan Imperial, Christina Kennedy, Goodner, Kaitlyn Hellner-Burris, José A. Hernandez, Cromes, Leonardo Curatti, Zijin Du, Eric Godsy, Brad Valla, Nalvo F. Almeida, Divya Balasubramanian, Lindsey Helga Ertesvåg, Guadelupe Espin, Luis M. Rubio, Svein João C. Setubal, Patricia dos Santos, Barry S. Goldman, Processes To Support Diverse Anaerobic Metabolic , an Obligate Aerobe Specialized vinelandii Azotobacter Genome Sequence of