Miracle-dz/UniFAR-FTUs huggingface dataset:
Mapping Choice of Healthcare Institutes for Cancer Care: A Study in Northeast India

Objective: To map and identify the sequence of visitation to institutes by patients with common cancers. Methods: This paper used a mixed method to follow a descriptive multiple-embedded case study. Participants selected in phase one were 388 by stratified random sampling, and in phase two, by purposive sampling, a semi-structured interview was conducted for 21 participants (15 participants and six key informants-oncologists: radiation - 2, medical - 2, surgical - 1 and gynaecology - 1). Ethical clearances were received from the study institutes. Informed consent was obtained from the participants. Results: Sparse research exists on mapping and choices of healthcare settings by cancer patients from northeast India. The main finding comprises a vivid overview of the decisions taken by cancer patients to get their necessary treatment based on all factors mitigating and inhibiting. Up to five hospitals for cancer treatment across the country. Private hospitals were preferred on the first visit by 74 percent (287), followed by the government by 26 percent (101); this, however, changes in subsequent hospital choices, with the latter preferred over the other, which could be due to the long duration of cancer treatment that is directly influenced by the paying capacity of the individual. Visitation was not limited to famous cancer hospitals, but few participants reported accessing herbal medicines, Ayurveda and Homoeopathy. Conclusion: Mapping patient choices of cancer institutes by patients from northeast India is essential as the challenges faced are unique to the region. By mapping patient choices of cancer institutes, insights into the preferred healthcare facilities can influence policies to improve the accessibility of cancer facilities. Findings from this study can support improving access to quality healthcare services, promoting cultural sensitivity, enhancing the quality of care, and informing policy planning and resource allocation.
Why in hospital following transoral robotic lingual tonsillectomy?

Abstract Background The reported hospital length of stay (LOS) following transoral robotic surgery lingual tonsillectomy (TORS-L) is variable, with limited understanding of the factors requiring hospitalization and no evidence-based criteria for discharge. Aims/objectives This observational cohort study investigated factors hindering discharge following TORS-L in a well-defined postoperative care program. Methods Patients were included between August 2020 and October 2022. A discharge scheme was filled out twice daily, specifying the factor(s) for hospitalization among patients undergoing TORS-L. This trial was a sub-investigation of a national multicentre randomized clinical trial (RCT) testing the efficiency of high-dose dexamethasone on postoperative pain control. Participation in the RCT demanded admission to the fourth postoperative day as dexamethasone/placebo was given intravenously in repeated dosages till day 4 postoperatively. Results Eighteen patients were included in the analysis. The main factor for hospitalization was nutritional difficulties, while pain was a limiting factor for discharge only on the first postoperative 1-3 days. More than half of the patients could have potentially been discharged on postoperative day 2 when omitting the RCT treatment plan in the analysis. Conclusion The study estimates that the majority of patients may be discharged on postoperative day 2 following TORS-L.
Reduced liver damage and fibrosis with combined SCD Probiotics and intermittent fasting in aged rat

Abstract This study aimed to examine the impact of SCD Probiotics supplementation on liver biomolecule content and histological changes during a 30‐day intermittent fasting (IF) program in 24‐month‐old male Sprague–Dawley rats. Rats underwent 18‐h daily fasting and received 1 × 108 CFU of SCD Probiotics daily. Liver tissue biomolecules were analysed using FTIR Spectroscopy, LDA, and SVM techniques, while histopathological evaluations used Haematoxylin and eosin and Masson trichrome‐stained tissues. Blood samples were collected for biochemical analysis. Gross alterations in the quantity of biomolecules were observed with individual or combined treatments. LDA and SVM analyses demonstrated a high accuracy in differentiating control and treated groups. The combination treatments led to the most significant reduction in cholesterol ester (1740 cm−1) and improved protein phosphorylation (A1239/A2955 and A1080/A1545) and carbonylation (A1740/A1545). Individually, IF and SCD Probiotics were more effective in enhancing membrane dynamics (Bw2922/Bw2955). In treated groups, histological evaluations showed decreased hepatocyte degeneration, lymphocyticinfiltration, steatosis and fibrosis. Serum ALP, LDH and albumin levels significantly increased in the SCD Probiotics and combined treatment groups. This study offers valuable insights into the potential mechanisms behind the beneficial effects of IF and SCD Probiotics on liver biomolecule content, contributing to the development of personalized nutrition and health strategies.
Analysis of urban growth and estimating population density using satellite images of nighttime lights and land-use and population data

We investigated the spatiotemporal dynamics of urban expansion in Japan from 1990 to 2006 by using gridded land-use data, population census data, and satellite images of nighttime lights. First, we mapped Defense Meteorological Satellite Program (DMSP) nighttime lights and land-use data onto the 1 km2 grid cell system of Japan to determine the proportional areas of DMSP and urban land use within each grid cell. Then, we investigated the relationships among population density, DMSP, and urban area. The urban/built-up area was strongly positively correlated with population density, and rapid expansion of the urban/built-up area around megacities was associated with population increases. In contrast, population density dropped steeply in rural areas and in small towns. Statistical analysis showed that correlation coefficients between population density and DMSP increased as the DMSP nighttime lights brightness value increased. We next estimated population density in the Hokkaido region using an ordinary least squares (OLS) regression model. Numerical evaluation of the results showed that the combination of land-use data and DMSP could be used to predict the population density. Finally, we compared OLS and geographically weighted regression (GWR) model for Sapporo city, Hokkaido. Compared with the OLS, the GWR can improve predictions of population density.
Association between seasonal influenza vaccination and antimicrobial use in Japan from the 2015–16 to 2020–21 seasons: from the VENUS study

Abstract Background Seasonal influenza vaccination might be considered an antimicrobial resistance (AMR) countermeasure because it can reduce unnecessary antimicrobial use for acute respiratory infection by mitigating the burden of such diseases. Objectives To examine the association between seasonal influenza vaccination and antimicrobial use (AMU) in Japan at the community level and to examine the impact of influenza vaccination on the frequency of unnecessary antimicrobial prescription for upper respiratory infection. Methods For patients who visited any healthcare facility in one of the 23 wards of Tokyo, Japan, due to upper respiratory infection and who were aged 65 years or older, we extracted data from the Vaccine Effectiveness, Networking, and Universal Safety (VENUS) study database, which includes all claims data and vaccination records from the 2015–16 to 2020–21 seasons. We used the average treatment effect (ATE) with 1:1 propensity score matching to examine the association of vaccination status with frequency of antibiotic prescription, frequency of healthcare facility consultation, risk of admission and risk of death in the follow-up period of the same season (from 1 January to 31 March). Results In total, 244 642 people were enrolled. Matched data included 101 734 people in each of the unvaccinated and vaccinated groups. The ATE of vaccination was −0.004 (95% CI −0.006 to −0.002) for the frequency of antibiotic prescription, −0.005 (−0.007 to −0.004) for the frequency of healthcare facility consultation, −0.001 (−0.002 to −0.001) for the risk of admission and 0.00 (0.00 to 0.00) for the risk of death. Conclusions Our results suggest that seasonal influenza vaccination is associated with lower frequencies of unnecessary antibiotic prescription and of healthcare facility consultation.
Immunohistochemical Study of the Expressed Cluster Differentiation Markers Proteins Type 20 And 56 in Breast Tissues from a Group of Iraqi Patients with Breast Cancers

Background: Tumor-infiltrating lymphocytes (TIL) are important immunological components in response to cancers. Patients with higher numbers of TIL in breast cancerous tissues, comprising T- cytotoxic and T – helper cells along with B- and rare natural killer (NK) cells, have more favorable clinical outcomes. Objective: To analyze the rate of the expressed surface biomarker proteins of CD20-B cells and CD56- NK cells on the infiltrative lymphocytic subpopulations in a group of breast tumorous tissues (invasive and benign) from female patients in Iraq and explore the relations to the grade of the invasive breast cancerous tissues. Patients and methods: One hundred and 75 archived breast tissues were enrolled in this retrospective research: 100 archived breast from female patients with invasive breast cancers (BC) [20 well differentiated BC tissues; 48 moderately differentiated BC and 32 poorly differentiated BC tissues]; 50 tissue biopsies from female patients with benign breast tumors and 25 apparently normal individuals with healthy breast tissues (included as the control group for this study). Immunohistochemistry was achieved for the detection of the expressed surface biomarker proteins related to B cell CD20 and NK cell CD56 present on the infiltrative lymphocytic subpopulations in breast tissues by using specific primary antibodies for these proteins via utilizing an immune-enzymatic antigen detection system. Results: The detection of IHC reactions for the expressed B cell CD20 - cell surface ( CD) biomarker proteins were observed in 53 out of 100 (53.0%) BC tissues, and in 24 out of 50 (48.0%) benign breast tumorous tissues, while CD20- positive cell surface markers was detected in apparently healthy breast tissues of the control group in a percentage of 32.0% (8 out of 25 tissues). Statistical significant differences (P<0.05) between both groups of malignant and benign breast tumors and the control group were found. However, between breast malignant and benign tumor groups, no significant difference was found ( p >0.05). Detection of CD56- IHC reactions revealed in 14% (14 out of 100 BC tissues), in 16% (8 out of 50 benign breast tissues) and none of control breast tissues revealed CD56- IHC reactions. Among all the enrolled groups, no significant differences (P>0.05) were detected. Conclusions: The observed significant rates that showed highly significant differences between both studied groups of breast malignant and benign tumor in comparison to the control group indicate that the CD20- positive infiltrative B cell- lymphocytic subpopulations might contributed in the defense against these subsets of benign and malignant breast tumors. However, the observed rates of NK cell CD56 present on the lymphocytic subpopulations infiltrating the examined malignant and benign breast tumorous tissues seeming to play irrelevant roles in the defense against these studied breast tumor groups.
Assessment of heavy metal stress in the adaptation strategies of Tulipa luanica growing on serpentine soil through some biomarkers in comparison to Tulipa kosovarica

Abstract The aim of this study was to gain a better understanding of how Tulipa luanica adapts to growth in soil with higher concentrations of heavy metals and to assess potential toxic effects using various biomarkers, in comparison to Tulipa kosovarica, a typical serpentine species. For this purpose, we analyzed the concentrations of Al, Ca, Cd, Co, Cr, Cu, Fe, Mg, Mn, Ni, Pb, and Zn in the soil, as well as their accumulation in plants and their associated stress effects. The results indicate that, despite the presence of some metals in very high concentrations in the soil (Al, Fe, Mn, and Ni), they are translocated in minimal amounts within plant organs, particularly in T. luanica. Nearly all metals exhibited significantly higher concentrations in T. kosovarica when compared to T. luanica. Based on the analysis of biomarkers, it is apparent that T. luanica shows greater sensitivity to these conditions. This is evident through the decreased activity of δ-aminolevulinic acid dehydratase and levels of δ-aminolevulinic acid, malondialdehyde, and glutathione observed in T. luanica. It appears that T. luanica effectively restricts the absorption of metals in serpentine soils; however, it experiences oxidative stress induced by these metals, setting it apart from the more resilient T. kosovarica.
Environmental Impacts on the Southern Florida Coastal Waters: A History of Change in Florida Bay

tHUHu. Analyses of four cores located in the northern transitional, eastern, and central portions of Florida Bay reveal histor ical patterns of change in salinity and seagrass distribution. Salinity and the distribution of seagrass beds are two critical issues for the restoration of Florida Bay. The distribution of benthic fauna in Bob Allen 6A and Russell Bank 19B cores illustrates changes in environmental parameters prior to 1900. Natural fluctuations occur in salinity, but the amplitude of those fluctuations was limited to a 15-20 % shift about the mean. Subtle changes occur in the benthic fauna around 1910, but beginning around 1940, the pattern of salinity fluctuation departs substantially from the pre 1900 pattern. Post-1940, the salinity oscillates 40-60 % about the mean. This pattern is seen in all indicators mea sured. Around 1970, a significant but short term decline occurred in salinity. The Taylor Creek T24 core from the northern transitional zone reflects changes in freshwater flow that have occurred during this century. The upper portion of the core records a significant increase in salinity, with a slight decrease occurring in recent years. The Pass Key 37 core represents an area of very high sedimentation rates; an increase in salinity occurs in the upper portion of the core. Natural fluctuations in seagrass distribution are inferred from the shifts in relative abundance of epiphytal species preserved in the cores. All four cores show an increase in epiphytes and therefore in seagrass coverage during this century. An increase also occurs in epiphytal species that can dwell on either Thalassia or macro-algal mats associated with Thalassia beds. These data suggest an increase in algal-mats has occurred during this century. The Bob Allen 6A core records an extensive period during the 1800's of little to no vegetative cover of the substrate based on the near absence of epiphytic species in that segment of the core. Following this period, the epiphytal species increase rapidly in abundance, implying that vegetation may have the ability to disseminate rapidly.
Reservoir capacity estimation using SARAL/AltiKa altimetry data coupled with Resourcesat P6-AWiFS and RISAT 1 microwave data

Abstract Reservoir water levels extracted from SARAL/AltiKa GDR data for the period 2013–2014 and water spread areas delineated from Resourcesat P6-AWiFS sensor and RISAT 1 microwave data corresponding to SARAL/AltiKa cycles were used for assessment of reservoir capacity in the Mayurakshi reservoir, Jharkhand state, India. It was found that the reservoir capacity based on the SARAL is around 474.62 Mm3 in comparison to in situ based estimate i.e. around 486.6 Mm3, indicating variation of <3%. Further, comparison of these estimates computed using SARAL and in situ with original reservoir capacity (547.59 Mm3) indicated loss of reservoir capacity is around 13.33 and 11.14%, respectively, within a span of 59 years. The hydrographic survey in the year 1999–2000 also proved that the storage capacity has reduced from 547.6 Mm3 in 1955 to 474.8 Mm3 indicating loss of nearly 13.3 % of total live capacity over period of 45 years.
Middle Carnian Arc-Type Basalts from the Lycian Nappes, Southwestern Anatolia: Early Late Triassic Subduction in the Northern Branch of Neotethys

The Turunç Unit, which represents one of the tectonic slices within the Lycian Nappes in southwestern Anatolia, preserves the remnants derived from the northern branch of Neotethys. The unit includes basalts intercalated with pelagic limestones of middle Carnian age (early Late Triassic) based on the characteristic radiolarian assemblage of the Tetraporobrachia haeckeli Zone. The Turunç lavas reflect trace element signatures resembling those from subduction zones, displaying selective enrichment of Th and light rare earth elements over high-field strength elements and heavy rare earth elements. Considering the overall geochemical characteristics of the Turunç basalts and given that they are found to be associated with no continent-derived detritus, the Turunç lavas appear to represent fragments of a Late Triassic island arc formed on the Neotethyan oceanic lithosphere. This result is of particular importance, since it reflects the oldest subduction age obtained from the entire Neotethyan realm to date. It may further indicate that the Neotethyan oceanic lithosphere had already been formed by the early Late Triassic, thus suggesting a pre–early Late Triassic oceanization of the northern branch of Neotethys. On the basis of this, we also suggest that the initial rifting leading to the opening of the northern branch of Neotethys should have taken place during the Middle Triassic or earlier.
Bacterial second messenger cyclic di‐AMP in streptococci

Cyclic dimeric adenosine monophosphate (c‐di‐AMP) has been well studied in bacteria, including those of the genus Streptococcus, since the first recognition of this dinucleotide in 2008. Streptococci possess a sole diadenylate cyclase, CdaA, and distinct c‐di‐AMP phosphodiesterases. Interestingly, cdaA is required for viability of some streptococcal species but not all when streptococci are grown in standard laboratory media. Bacteria of this genus also have distinct c‐di‐AMP effector proteins, diverse c‐di‐AMP‐signaling pathways, and subsequent biological outcomes. In streptococci, c‐di‐AMP may influence bacterial growth, morphology, biofilm formation, competence program, drug resistance, and bacterial pathogenesis. c‐di‐AMP secreted by streptococci has also been shown to interact with the mammalian host and induces immune responses including type I interferon production. In this review, we summarize the reported c‐di‐AMP networks in seven species of the genus Streptococcus, which cause diverse clinical manifestations, and propose future perspectives to investigate the signaling molecule in these streptococcal pathogens.
Association between genetically predicted circulating immune cells on periodontitis highlights the prospect of systemic immunomodulation management in periodontal care: a Mendelian randomization study

Background: Periodontitis drives irreparable destruction of periodontal tissue and possesses a tendency to aggravate inflammatory disorders. Systemic immunomodulation management remains an attractive approach in periodontal care within a context of "predictive, preventive, and personalized" periodontics. Leveraging a comprehensive Mendelian randomization (MR), the present study aims to evaluate the causal relationships between circulating immune cells and the risk of periodontitis. Methods: Genetic proxies for circulating immune cells and periodontitis were obtained from genome-wide association studies. We performed a two-sample bidirectional univariable Mendelian Randomization, followed by sensitivity testing, multivariable MR, subgroup analysis, and Bayesian model averaging (MR-BMA) to explore the causal association between them. The transcriptome-wide association study (TWAS) and colocalization analysis were further conducted to identify responsible genes as immunomodulation candidates for periodontal care. Results: MR study indicated that circulating neutrophils, Natural Killer T cells, and plasmacytoid Dendritic Cells were relative to a higher risk of periodontitis, with no evidence of heterogeneity or pleiotropy. The MR-BMA identified neutrophils as the primary factor responsible for periodontitis. The TWAS recognized five cross-trait genes to be involved in their interaction. Two high-confidence genes on 1q21.3, S100A9 and S100A12, could represent immunomodulation targets for neutrophils in periodontitis. Conclusions: The present study suggests the causative association between circulating immune cells and the risk of periodontitis. Our findings highlight the prospect of systemic immunomodulation management in periodontal care, which can be valuable for early diagnostics, risk assessment, targeted prevention, and personalized management of periodontitis. More research is required to comprehend the biological plausibility and clinical applicability of our findings.
Invariants of Vanishing Brauer Classes

A specialization of a K3 surface with Picard rank one to a K3 with rank two defines a vanishing class of order two in the Brauer group of the general K3 surface. We give the B-field invariants of this class. We apply this to the K3 double plane defined by a cubic fourfold with a plane. The specialization of such a cubic fourfold whose group of codimension two cycles has rank two to one which has rank three induces such a specialization of the double planes. We determine the Picard lattice of the specialized double plane as well as the vanishing Brauer class and its relation to the natural"Clifford"Brauer class. This provides more insight in the specializations. It allows us to explicitly determine the K3 surfaces associated to infinitely many of the conjecturally rational cubic fourfolds obtained as such specializations.
OpinSummEval: Revisiting Automated Evaluation for Opinion Summarization

Opinion summarization sets itself apart from other types of summarization tasks due to its distinctive focus on aspects and sentiments. Although certain automated evaluation methods like ROUGE have gained popularity, we have found them to be unreliable measures for assessing the quality of opinion summaries. In this paper, we present OpinSummEval, a dataset comprising human judgments and outputs from 14 opinion summarization models. We further explore the correlation between 24 automatic metrics and human ratings across four dimensions. Our findings indicate that metrics based on neural networks generally outperform non-neural ones. However, even metrics built on powerful backbones, such as BART and GPT-3/3.5, do not consistently correlate well across all dimensions, highlighting the need for advancements in automated evaluation methods for opinion summarization. The code and data are publicly available at https://github.com/A-Chicharito-S/OpinSummEval/tree/main.
On Lieb-Robinson bounds for a class of continuum fermions

We consider the quantum dynamics of a many-fermion system in $\mathbb R^d$ with an ultraviolet regularized pair interaction as previously studied in [M. Gebert, B. Nachtergaele, J. Reschke, and R. Sims, Ann. Henri Poincar\'e 21.11 (2020)]. We provide a Lieb-Robinson bound under substantially relaxed assumptions on the potentials. We also improve the associated one-body Lieb-Robinson bound on $L^2$-overlaps to an almost ballistic one (i.e., an almost linear light cone) under the same relaxed assumptions. Applications include the existence of the infinite-volume dynamics and clustering of ground states in the presence of a spectral gap. We also develop a fermionic continuum notion of conditional expectation and use it to approximate time-evolved fermionic observables by local ones, which opens the door to other applications of the Lieb-Robinson bounds.