Miracle-dz/UniFAR-FTUs huggingface dataset:
A Qualitative Evaluation of the Barriers and Enablers for Implementation of an Asymptomatic SARS-CoV-2 Testing Service at the University of Nottingham: A Multi-Site Higher Education Setting in England

Asymptomatic testing for SARS-CoV-2 RNA has been used to prevent and manage COVID-19 outbreaks in university settings, but few studies have explored their implementation. The aim of the study was to evaluate how an accredited asymptomatic SARS-CoV-2 testing service (ATS) was implemented at the University of Nottingham, a multi-campus university in England, to identify barriers and enablers of implementation and to draw out lessons for implementing pandemic response initiatives in higher education settings. A qualitative interview study was conducted with 25 ATS personnel between May and July 2022. Interviews were conducted online, audio-recorded, and transcribed. Participants were asked about their experience of the ATS, barriers and enablers of implementation. Transcripts were thematically analysed. There were four overarching themes: (1) social responsibility and innovation, (2) when, how and why people accessed testing, (3) impact of the ATS on the spread of COVID-19, and (4) lessons learned for the future. In establishing the service, the institution was seen to be valuing its community and socially responsible. The service was viewed to be broadly successful as a COVID-19 mitigation approach. Challenges to service implementation were the rapidly changing pandemic situation and government advice, delays in service accreditation and rollout to staff, ambivalence towards testing and isolating in the target population, and an inability to provide follow-up support for positive cases within the service. Facilitators included service visibility, reduction in organisational bureaucracy and red tape, inclusive leadership, collaborative working with regular feedback on service status, flexibility in service delivery approaches and simplicity of saliva testing. The ATS instilled a perception of early ‘return to normality’ and impacted positively on staff feelings of safety and wellbeing, with wider benefits for healthcare services and local communities. In conclusion, we identified common themes that have facilitated or hindered the implementation of a SARS-CoV-2 testing service at a university in England. Lessons learned from ATS implementation will inform future pandemic response interventions in higher education settings.
The Psychological Distress and Quality of Life of Breast Cancer Survivors in Sydney, Australia

In Australia, breast cancer is one of the most common cancers affecting women. Between 1987–1991 and 2012–2016, the five-year survival rate improved from 75% to 91%. The increased chance of survival due to early detection and treatment interventions has resulted in more women living with the diagnosis. This qualitative study was designed to analyse the journey of breast cancer survivors, their experience of psychological distress and changes in quality of life (QOL) due to the increased prevalence amongst Australian women. In-depth interviews were conducted; they lasted over 45 min and comprised 15 participants. The main topics discussed were knowledge of breast cancer prior to diagnosis, psychological distress, QOL and experience of use of healthcare services. The results showed that the process of diagnosis, undergoing treatment and isolation post-treatment resulted in high amounts of psychological distress. A reduction in QOL was also experienced due to treatment and medication side effects, fatigue, cognitive changes, and body-image perception. These findings can assist researchers in providing evidence-based frameworks for policy changes and for further investigation into effective healthcare interventions.
Immunization with a Prefusion SARS-CoV-2 Spike Protein Vaccine (RBMRNA-176) Protects against Viral Challenge in Mice and Nonhuman Primates

There is an urgent need for a broad-spectrum and protective vaccine due to the emergence and rapid spreading of more contagious SARS-CoV-2 strains. We report the development of RBMRNA-176, a pseudouridine (Ψ) nucleoside-modified mRNA-LNP vaccine encoding pre-fusion stabilized trimeric SARS-CoV-2 spike protein ectodomain, and evaluate its immunogenicity and protection against virus challenge in mice and nonhuman primates. A prime-boost immunization with RBMRNA-176 at intervals of 21 days resulted in high IgG titers (over 1:819,000 endpoint dilution) and a CD4+ Th1-biased immune response in mice. RBMRNA-176 vaccination induced pseudovirus-neutralizing antibodies with IC50 ranging from 1:1020 to 1:2894 against SARS-CoV-2 spike pseudotyped wild-type and variant viruses, including Alpha, Beta, Gamma, and Kappa. Moreover, significant control of viral replication and histopathology in lungs was observed in vaccinated mice. In nonhuman primates, a boost given by RBMRNA-176 on day 21 after the prime induced a persistent and sustained IgG response. RBMRNA-176 vaccination also protected macaques against upper and lower respiratory tract infection, as well as lung injury. Altogether, these findings support RBMRNA-176 as a vaccine candidate for prevention of COVID-19.
Does the efficiency of working capital management and environmental, social, and governance performance affect a firm’s value? Evidence from the United States

Abstract This study evaluates the efficiency of U.S. firms’ working capital management (WCME) by employing the data envelopment analysis technique (DEA). This study uses regression analysis to examine the impact of WCME and environmental, social, and governance (ESGP) performance on U.S. firm value. This study uses a data sample consisting of 964 firm-year observations from a longitudinal panel collected from 2016 to 2019. Endogeneity issues and the employment of additional analyses for robustness were considered. The results indicated that most firms under investigation were relatively inadequate regarding WCME and required correctional efforts by decision-makers to accomplish most reasonable efficiency, directly related to enhancing firm sales and net income. Additionally, the results reveal significant and positive influences of WCME and ESGP on firm value. The implications of this study would push decision-makers to employ the most reasonable procedures and strategies to improve the activities of a firm’s WCM and ESG to boost its value and excel in the business environment.
Pb-Pb collisions at $\sqrt{s_{NN}}=2.76$ TeV in a multiphase transport model

The multiplicity and elliptic flow of charged particles produced in Pb-Pb collisions at center of mass energy $\sqrt{s_{NN}}=2.76$ TeV from the Large Hadron Collider are studied in a multiphase transport (AMPT) model. With the standard parameters in the HIJING model, which is used as initial conditions for subsequent partonic and hadronic scatterings in the AMPT model, the resulting multiplicity of final charged particles at mid-pseudorapidity is consistent with the experimental data measured by the ALICE Collaboration. This value is, however, increased by about 25% if the final-state partonic and hadronic scatterings are turned off. Because of final-state scatterings, particular those among partons, the final elliptic flow of charged hadrons is also consistent with the ALICE data if a smaller but more isotropic parton scattering cross section than previously used in the AMPT model for describing the charged hadron elliptic flow in heavy ion collisions at the Relativistic Heavy Ion Collider is used. The resulting transverse momentum spectra of charged particles as well as the centrality dependence of their multiplicity density and the elliptic flow are also in reasonable agreement with the ALICE data. Furthermore, the multiplicities, transverse momentum spectra and elliptic flows of identified hadrons such as protons, kaons and pions are predicted.
Institutional Responses to Inclusion from Around the World

In this review, a volume will be presented which presents and supports the understanding and practicality of inclusion and equity. This book was published in the UK, but the authors and the practices presented come from different parts of the world. As this is part of a series, the book begins with the series editor’s introduction. The aim of the series is to present innovative teaching and learning practices around the world, the latest adaptation methods that educators should consider when putting a model into practice, and the relationship between theory and practice to policy and strategic planning. In the editorial foreword to Part 1 of the series, the editors briefly describe the structure of the publication and the concepts and terms included in the studies. In this introduction, there are many connections with the inclusive policies in higher education in Pécs, Hungary (ArAtó &VArgA 2015): • inclusion is a process, and diversity is a state rather than the result of some kind of stand-alone, one-time event • when creating an inclusive campus, it is very important to involve and engage decision-makers • the process of reception affects all actors and participants of the environment and institution • In the 21st century, diversity in higher education is essential for achieving academic success
Turbulent mixing and a generalized phase transition in shear-thickening fluids

This paper presents a new theory of turbulent mixing in stirred reactors. The degree of homogeneity of a mixed fluid may be characterized by the Kolmogorov micro-scale. The smaller its value, the better homogeneity. The micro-scale scales inversely with the fourth root of the energy dissipation rate in the stirring process. The higher this rate, the smaller lambda, and the better the homogeneity in the reactor. This is true for Newtonian fluids. In non-Newtonian fluids the situation is different. For instance, in shear-thickening fluids it is plausible that high shear rates thicken the fluid and might strangle the mixing. The internal interactions between different fluid-mechanical and colloidal variables are subtle, namely due to the (until recently) very limited understanding of turbulence. Starting from a qualitatively new turbulence theory for inviscid fluids [Baumert, 2013], giving e.g. the Karman constant as $(2\pi)^{-1/2} = 0.40$ [the super-pipe in Princeton gave 0.40 p/m 0.02, Bailey et al., 2014], we generalize this approach to the case of viscous fluids and derive equations which in the steady state exhibit two solutions. One solution branch describes a state of good mixing, the other a state of strangled turbulence. The physical system cannot be in two different steady states at the same time. But it is physically admissible to switch between the two steady states by non-stationary transitions, maybe in a chaotic fashion.
On Pumping RP-automata Controlled by Complete LRG(\cent, $)-grammars

We introduce complete LR(0)-grammars with sentinels (called complete LR(¢,$)-grammars) to prepare tools for the study of pumping restarting automata controlled by this type of grammars. A complete LR(¢,$)-grammar generates both a language and the complement of the language with sentinels. Based on a complete LR(¢,$)-grammar, we can construct a deterministic pumping restarting automaton performing pumping analysis by reduction on each word over its input alphabet. A pumping reduction analysis is a method where an input word is stepwise simplified by removing at most two continuous parts of the current word in a way that preserves (in)correctness of the word. Each such simplification corresponds to removing parts of the current word that could be “pumped” in the sense of a pumping lemma for context-free languages. The computation of a pumping restarting automaton ends when the original word is shortened under a given length, and then it is decided about the correctness or incorrectness of the original input word. This means that pumping restarting automata can analyze both correct and incorrect inputs with respect to a deterministic context-free language (DCFL). That gives an excellent formal basis for the error localization and the error recovery of DCFL.
Determinants of the Impact of Fatigue on the Health of Polish Nursing Students during the COVID-19 Pandemic

(1) Lockdown-related fatigue occurring during the COVID-19 pandemic is a complex problem that can be experienced in different social groups. The objective of the current study is to attempt to identify socio-demographic and lifestyle-related factors that determine the impact of fatigue on health in general as well as in physical, cognitive, and psychosocial terms and to determine whether, and to what extent, these were predictors of fatigue in nursing students during the COVID-19 pandemic. (2) The study was conducted by the diagnostic poll method between 20 March and 15 December 2021 among 894 nursing students at six Polish universities. To collect the data, a validated Modified Fatigue Impact Scale (MFIS) was used. (3) Students from the age group of ≤20 experienced a significantly greater impact of fatigue on health in general as well as in physical and cognitive terms. The study demonstrated a significant negative relationship between the year of study and the impact of fatigue on health in general terms (r = −0.12; p < 0.0001) and the analyzed health terms, on physical (r = −0.12; p < 0.0001), cognitive (r = −0.10; p < 0.002), and psychosocial (r = −0.07; p < 0.041). In predicting the impact of fatigue on health in general and physical terms, it was the variable related to a reduction in physical activity during the COVID-19 pandemic that had the greatest contribution, while for the cognitive and psychosocial functions, it was the number of meals consumed per day. (4) It is recognized that action is needed to reduce the impact of fatigue on student health by modifying the predictors related to student lifestyles.
A Review of Omics Studies on Arboviruses: Alphavirus, Orthobunyavirus and Phlebovirus

Since the intricate and complex steps in pathogenesis and host-viral interactions of arthropod-borne viruses or arboviruses are not completely understood, the multi-omics approaches, which encompass proteomics, transcriptomics, genomics and metabolomics network analysis, are of great importance. We have reviewed the omics studies on mosquito-borne viruses of the Togaviridae, Peribuyaviridae and Phenuiviridae families, specifically for Chikungunya, Mayaro, Oropouche and Rift Valley Fever viruses. Omics studies can potentially provide a new perspective on the pathophysiology of arboviruses, contributing to a better comprehension of these diseases and their effects and, hence, provide novel insights for the development of new antiviral drugs or therapies.
The OGLE view of microlensing towards the Magellanic Clouds – IV. OGLE-III SMC data and final conclusions on MACHOs

In this fourth part of the series presenting the Optical Gravitational Lensing Experiment (OGLE) microlensing studies of the dark matter halo compact objects (MACHOs), we describe results of the OGLE-III monitoring of the Small Magellanic Cloud (SMC). Three sound candidates for microlensing events were found and yielded the optical depth τSMC-OIII= 1.30 ± 1.01 × 10−7, consistent with the expected contribution from Galactic disc and SMC self-lensing. We report that event OGLE-SMC-03 is most likely a thick-disc lens candidate, the first of such type found towards the SMC. In this paper we also combined all OGLE Large Magellanic Cloud and SMC microlensing results in order to refine the conclusions on MACHOs. All but one of the OGLE events are most likely caused by the lensing by known populations of stars; therefore, we concluded that there is no need for introducing any special dark matter compact objects in order to explain the observed event rates. Potential black hole event indicates that similar lenses can contribute only about 2 per cent to the total mass of the halo, which is still in agreement with the expected number of such objects.
FOLFIRINOX Pharmacodynamic Interactions in 2D and 3D Pancreatic Cancer Cell Cultures

The multi-drug combination regime, FOLFIRINOX, is a standard of care chemotherapeutic therapy for pancreatic cancer patients. However, systematic evaluation of potential pharmacodynamic interactions among multi-drug therapy has not been reported previously. Here, pharmacodynamic interactions of the FOLFIRINOX agents (5-fluorouracil (5-FU), oxaliplatin (Oxa) and SN-38, the active metabolite of irinotecan) were assessed across a panel of primary and established pancreatic cancer cells. Inhibition of cell proliferation was quantified for each drug, alone and in combination, to obtain quantitative, drug-specific interaction parameters and assess the nature of drug interactions. The experimental data were analysed assuming Bliss independent interactions, and nonlinear regression model fitting was conducted in SAS. Estimates of the drug interaction term, psi (ψ), revealed that the Oxa/SN-38 combination appeared synergistic in PANC-1 (ψ = 0.6, 95% CI = 0.4, 0.9) and modestly synergistic, close to additive, in MIAPaCa-2 (ψ = 0.8, 95% CI = 0.6, 1.0) in 2D assays. The triple combination was strongly synergistic in MIAPaCa-2 (ψ = 0.2, 95% CI = 0.1, 0.3) and modestly synergistic/borderline additive in PANC-1 2D (ψ = 0.8, 95% CI = 0.6, 1.0). The triple combination showed antagonistic interactions in the primary PIN-127 and 3D PANC-1 model (ψ > 1). Quantitative pharmacodynamic interactions have not been described for the FOLFIRINOX regimen; this analysis suggests a complex interplay among the three chemotherapeutic agents. Extension of this pharmacodynamic analysis approach to clinical/translational studies of the FOLFIRINOX combination could reveal additional pharmacodynamic interactions and guide further refinement of this regimen to achieve optimal clinical responses.
Numerical estimates of the accretion rate on to intermediate-mass black holes

The existence of intermediate-mass ($\sim 10^3 M_\odot$) black holes in the center of globular clusters has been suggested by different observations. The X-ray sources observed in NGC 6388 and in G1 in M31 could be interpreted as being powered by the accretion of matter onto such objects. In this work we explore a scenario in which the black hole accretes from the cluster interstellar medium, which is generated by the mass loss of the red giants in the cluster. We estimate the accretion rate onto the black hole and compare it to the values obtained via the traditional Bondi-Hoyle model. Our results show that the accretion rate is no longer solely defined by the black hole mass and the ambient parameters but also by the host cluster itself. Furthermore, we find that the more massive globular clusters with large stellar velocity dispersion are the best candidates in which accretion onto IMBHs could be detected.
The nuclear and integrated far-infrared emission of nearby Seyfert galaxies

We present far-infrared (FIR) $70-500\,\mu$m imaging observations obtained with Herschel/PACS and SPIRE of 33 nearby (median distance of 30 Mpc) Seyfert galaxies from the Revised Shapley-Ames (RSA) catalogue. We obtain the FIR nuclear ($r=1\,$kpc and $r=2\,$kpc) and integrated spectral energy distributions (SEDs). We estimate the unresolved nuclear emission at 70 $\mu$m and we fit the nuclear and integrated FIR SEDs with a grey body model. We find that the integrated FIR emission of the RSA Seyferts in our sample is dominated by emission from the host galaxy, with dust properties similar to those of normal galaxies (non AGN). We use four criteria to select galaxies whose nuclear $70\,\mu$m emission has a significant AGN contribution: (1) elevated 70/160 $\mu$m flux ratios, (2)spatially resolved, high dust temperature gradient, (3) $70\,\mu$m excess emission with respect to the fit of the FIR SEDs with a grey body, and (4) excess of nuclear SFR obtained from $70\,\mu$m over SFR from mid-infrared indicators. 16 galaxies (48 per cent of the initial sample) satisfy at least one of these conditions, whereas 10 satisfy half or more. After careful examination of these, we select six bona fide candidates (18 per cent of the initial sample) and estimate that $\sim 40-70$ per cent of their nuclear ($r=1-2\,$kpc) $70\,\mu$m emission is contributed by dust heated by the AGN.
Iterative Rounding Approximation Algorithms in Network Design

Iterative rounding has been an increasingly popular approach to solving network design optimization problems ever since Jain introduced the concept in his revolutionary 2-approximation for the Survivable Network Design Problem (SNDP) [33]. This paper looks at several important iterative rounding approximation algorithms and makes improvements to some of their proofs. We generalize a matrix restatement of Nagarajan et al.’s token argument from [42] which we can use to simplify the proofs of Jain’s 2-approximation for SNDP and Fleischer et al.’s 2-approximation for the Element Connectivity (ELC) problem. Lau et al. [38] show how one can construct a (2, 2B + 3)approximation for the degree bounded ELC problem, and this thesis provides the proof. We provide some structural results for basic feasible solutions of the Prize-Collecting Steiner Tree problem, and introduce a new problem that arises, which we call the Prize-Collecting Generalized Steiner Tree problem.
Aperiodic optical variability of intermediate polars – cataclysmic variables with truncated accretion disks

We study the power spectra of the variability of seven intermediate polars containing magnetized asynchronous accreting white dwarfs, XSS J00564+4548, IGR J00234+6141, DO Dra, V1223 Sgr, IGR J15094-6649, IGR J16500-3307 and IGR J17195-4100, in the optical band and demonstrate that their variability can be well described by a model based on fluctuations propagating in a truncated accretion disk. The power spectra have breaks at Fourier frequencies, which we associate with the Keplerian frequency of the disk at the boundary of the white dwarfs' magnetospheres. We propose that the properties of the optical power spectra can be used to deduce the geometry of the inner parts of the accretion disk, in particular: 1) truncation radii of the magnetically disrupted accretion disks in intermediate polars, 2) the truncation radii of the accretion disk in quiescent states of dwarf novae.
Optical and Infrared Photometry of the Nearby Type Ia Supernova 2001el

We present well-sampled optical (UBVRI) and infrared (JHK) light curves of the nearby (≈18.0 Mpc) Type Ia supernova SN 2001el, from 11 days before to 142 days after the time of B-band maximum. The data represent one of the best sets of optical and infrared photometry ever obtained for a Type Ia supernova (SN). Based on synthetic photometry using optical spectra of SN 2001el and optical and infrared spectra of SN 1999ee, we were able to devise filter corrections for the BVJHK photometry of SN 2001el, which to some extent resolve systematic differences between SN 2001el data sets obtained with different telescope/filter/instrument combinations. We also calculated V-minus-infrared color curves on the basis of a delayed detonation model and show that the theoretical color curves match the unreddened loci for Type Ia SNe with midrange decline rates to within 0.2 mag. Given the completeness of the light curves and the elimination of filter-oriented systematic errors to some degree, the data presented here will be useful for the construction of photometric templates, especially in the infrared. On the whole the photometric behavior of SN 2001el was quite normal. The second H-band maximum being brighter than the first H-band maximum is in accord with the prediction of Krisciunas et al. for Type Ia SNe with midrange decline rates. The photometry exhibits nonzero host extinction, with total AV = 0.57 ± 0.05 mag along the line of sight. NGC 1448, the host of SN 2001el, would be an excellent target for a distance determination using Cepheids.