Miracle-dz/UniFAR-FTUs huggingface dataset:
The effects of camelina sativa oil and high-intensity interval training on liver function and metabolic outcomes in male type 2 diabetic rats

Objectives The purpose of this study was to evaluate the independent and combined effects of camelina sativa oil and high-intensity interval training (HIIT) on liver function, and metabolic outcomes in streptozotocin-induced diabetic rats. Methods Forty male Wistar rats were randomly assigned to five equal groups (8 per group): Normal control (NC), diabetic control (DC), diabetic + camelina sativa oil (300 mg/kg by oral gavage per day; D + CSO), diabetic + HIIT (running on a treadmill 5 days/week for 8 weeks; D + HIIT), diabetic + camelina sativa oil + HIIT (D + CSO + HIIT). Results In all three intervention groups (D + CSO, D + HIIT, and D + CSO + HIIT) compared to the DC, hepatic TNF-α, MDA, and histopathology markers, decreased and hepatic PGC-1α, and PPAR-γ increased (p < 0.05). However, the effect of D + CSO was greater than D + HIIT alone. Hepatic TG decreased significantly in D + HIIT and D + CSO + HIIT compared to other groups (p < 0.001). Fasting plasma glucose in all three intervention groups (D + CSO, D + HIIT, and D + CSO + HIIT) and HOMA-IR in D + CSO and D + CSO + HIIT were decreased compared to DC (p < 0.001). Only hepatic TAC and fasting plasma insulin remained unaffected in the three diabetic groups (p < 0.001). Overall, D + CSO + HIIT had the largest effect on all outcomes. Conclusions At the doses and treatment duration used in the current study, combination of CSO and HIIT was beneficial for reducing liver function and metabolic outcomes other than CSO and HIIT alone.
Microcavity polariton spin quantum beats without a magnetic field: A manifestation of Coulomb exchange in dense and polarized polariton systems

Microcavity polariton spin dynamics is investigated in high-finesse microcavities under resonant excitation using polarization- and time-resolved secondary emission spectroscopy. Using an appropriate calibration procedure, the instantaneous polariton occupation numbers of the modes with $\mathbf{k}\ensuremath{\approx}\mathbf{0}$ wave vectors can be determined. When the phase-matching conditions are achieved, we show that Coulomb scattering dominates the other processes, and that stimulation occurs when the occupation of the $\mathbf{k}\ensuremath{\approx}\mathbf{0}$ final state with a given mode polarization approaches unity. Under elliptically polarized light, we show that the stimulated polariton scattering leads to an increase with time of the circular polarization of the $\mathbf{k}\ensuremath{\approx}\mathbf{0}$ states, while the linear polarization dynamics is characterized first by a fast drop to negative or zero values immediately after the excitation pulse, followed by weak-amplitude nonperiodic oscillations. The latter are interpreted as the manifestation of the pseudospin precession of the pumped polariton modes around the self-induced exchange effective field.
Measurement/computation of effective permittivity of dilute solution in saponification reaction

For better application of microwaves in chemistry, the interaction between microwaves and the chemical reaction needs further study. Since the reactants form a complicated mixture, which changes with time, an effective permittivity can be used to describe the molecular polarization of the mixture in the reaction. The effective permittivity is expected to change with microwave frequency, temperature and reaction time. However, in many cases, the change of effective permittivity in a saponification reaction is too small to be detected using traditional methods. In this paper, we present a hybrid experimental/computational method for determining the effective permittivity in a saponification reaction. We use a resonant coaxial sensor to measure the reflection coefficients. To predict its performance, the electromagnetic-field distribution near the sensor and the reflection coefficient are calculated employing a frequency-dependent finite-difference time-domain method. Next, we develop a genetic-algorithm-based inverse-calculation technique and employ it to determine the complex permittivity of pure water from the measured reflection coefficient and compare the results with those obtained from Debye's equation. Finally, the hybrid experimental/computational method is employed to determine the effective permittivity of a dilute solution in a typical saponification reaction. Results are presented and discussed.
Interpolative BTC image coding

Two interpolative block truncation coding (BTC) schemes with vector quantization (VQ) and median filters as the interpolator are proposed. The first scheme is based on quincunx subsampling and the second one on every-other-row-and-every-other-column subsampling. Compared to the standard BTC, the new schemes yield a significant reduction in bit rate, only a small degradation in quality, and better channel error resisting capabilities. Moreover, the methods are shown to outperform the BTC schemes with pure VQ at the same bit rate and require minimal computations for the interpolation. <<ETX>>
Two-dimensional Ising Field Theory in a Magnetic Field: Breakup of the Cut in the Two Point Function

We demonstrate that the cut which is present as the leading singularity in the two-point function of the Ising field theory for T < T/sub c/ and H not = 0 breaks up into a sequence of poles for H = 0. Both the positions and the residues of the low-lying poles are calculated.
Second‐order optimal control algorithm for complex systems

The solution to large‐scale optimal control problems, characterized by complex dynamics and extended time periods, is often computationally demanding. We present a solution algorithm with favourable local convergence properties as a way to reduce simulation times. This method is based on using a trapezoidal direct collocation to convert the differential equations into algebraic constraints. The resulting constrained minimization problem is then solved with an augmented Lagrangian formulation to accommodate both equality and inequality constraints. In contrast to the prevalent optimal control software implementations, we calculate analytical first and second derivatives. We then apply a generalized Newton method to the augmented Lagrangian formulation, solving for all unknowns simultaneously. The computational costs of the Hessian formation and matrix solution remain manageable as the system size increases due to the sparsity of all tensor quantities. Likewise, the total iterations for convergence scale well due to the local quadratic convergence of the generalized Newton method. We demonstrate the method with an inverted pendulum problem and a neuromuscular control problem with complex dynamics and 18 forcing functions. The optimal control solutions are successfully found. In both examples, we obtain quadratic convergence rates in the neighbourhood of the solution. Copyright © 2002 John Wiley & Sons, Ltd.
On the onset of high-Reynolds-number grid-generated wind tunnel turbulence

Using an active grid devised by Makita (1991), shearless decaying turbulence is studied for the Taylor-microscale Reynolds number, Rλ, varying from 50 to 473 in a small (40 × 40 cm2 cross-section) wind tunnel. The turbulence generator consists of grid bars with triangular wings that rotate and flap in a random way. The value of Rλ is determined by the mean speed of the air (varied from 3 to 14 m s–1) as it passes the rotating grid, and to a lesser extent by the randomness and rotation rate of the grid bars. Our main findings are as follows. A weak, not particularly well-defined scaling range (i.e. a power-law dependence of both the longitudinal (u) and transverse (v) spectra, F11(k1) and F22(k1) respectively, on wavenumber k1) first appears at Rλ ∼ 50, with a slope, n1, (for the u spectrum) of approximately 1.3. As Rλ was increased, n1 increased rapidly until Rλ ∼ 200 where n ∼ 1.5. From there on the increase in n1 was slow, and even by Rλ = 473 it was still significantly below the Kolmogorov value of 1.67. Over the entire range, 50 [les ] Rλ [les ] 473, the data were well described by the empirical fit: $n_1 = \frac{5}{3}(1-3.15R_\lambda^{-2/3})$. Using a modified form of the Kolmogorov similarity law: F11(k1) = C1*ε2/3k1–5/3(k 1η)5/3–n1 where ε is the turbulence energy dissipation rate and η is the Kolmogorov microscale, we determined a linear dependence between n1 and C1*: C1* = 4.5 – 2.4n1. Thus for n1 = 5/3 (which extrapolation of our results suggests will occur in this flow for Rλ ∼ 104), C1* = 0.5, the accepted high-Reynolds-number value of the Kolmogorov constant. Analysis of the p.d. f. of velocity differences Δu(r) and Δv(r) where r is an inertial subrange interval, conditional dissipation, and other statistics showed that there was a qualitative difference between the turbulence for Rλ < 100 (which we call weak turbulence) and that for Rλ > 200 (strong turbulence). For the latter, the p.d. f.s of Δu(r) and Δv(r) had super Gaussian tails and the dissipation (both of the u and v components) conditioned on Δu(r) and Δv(r) was a strong function of the velocity difference. For Rλ < 100, p.d. f.s of Δu(r) and Δv(r) were Gaussian and conditional dissipation statistics were weak. Our results for Rλ > 200 are consistent with the predictions of the Kolmogorov refined similarity hypothesis (and make a distinction between the dynamical and kinematical contributions to the conditional statistics). They have much in common with similar statistics done in shear flows at much higher Rλ, with which they are compared.
Relative intensity noise for laser diodes with arbitrary amounts of optical feedback

A unified study of the noise characteristics of semiconductor lasers with optical feedback and short external cavity length is presented. A new set of nonlinear rate equations that can describe a laser diode with any amount of optical feedback is proposed. The relative intensity noise (RIN) is calculated by using a numerical solution of these equations. This paper concentrates mainly on the moderate and strong feedback regimes. The spectral phenomena observed during the transition from the weak feedback to the "coherence collapse" regime and then to the strong feedback regime are studied and explained. The effect of the variation of some of the laser diode parameters on the RIN characteristics is also investigated.
Intestine microbiota and SCFAs response in naturally Cryptosporidium-infected plateau yaks

Diarrhea is a severe bovine disease, globally prevalent in farm animals with a decrease in milk production and a low fertility rate. Cryptosporidium spp. are important zoonotic agents of bovine diarrhea. However, little is known about microbiota and short-chain fatty acids (SCFAs) changes in yaks infected with Cryptosporidium spp. Therefore, we performed 16S rRNA sequencing and detected the concentrations of SCFAs in Cryptosporidium-infected yaks. Results showed that over 80,000 raw and 70,000 filtered sequences were prevalent in yak samples. Shannon (p<0.01) and Simpson (p<0.01) were both significantly higher in Cryptosporidium-infected yaks. A total of 1072 amplicon sequence variants were shared in healthy and infected yaks. There were 11 phyla and 58 genera that differ significantly between the two yak groups. A total of 235 enzymes with a significant difference in abundance (p<0.001) were found between healthy and infected yaks. KEGG L3 analysis discovered that the abundance of 43 pathways was significantly higher, while 49 pathways were significantly lower in Cryptosporidium-infected yaks. The concentration of acetic acid (p<0.05), propionic acid (p<0.05), isobutyric acid (p<0.05), butyric acid (p<0.05), and isovaleric acid was noticeably lower in infected yaks, respectively. The findings of the study revealed that Cryptosporidium infection causes gut dysbiosis and results in a significant drop in the SCFAs concentrations in yaks with severe diarrhea, which may give new insights regarding the prevention and treatment of diarrhea in livestock.
Antineuroinflammatory Properties of Compounds from Ethyl Acetate Fraction of Marsilea crenata C. Presl. Against Toll-Like Receptor 2 (3A7B) In Silico

Parkinson's disease (PD) can be triggered by overactive TLR2 due to α-synuclein abnormalities and aggregation. Marsilea crenata C. Presl. leaves inhibit neuroinflammatory progression. This study aimed to predict the antineuroinflammatory activity of M. crenata leaves with TLR2 (ID 3A7B) in an in silico study. The list of chemicals was collected through metabolite profiling with UPLC-QToF MS/MS, then analyzed for physicochemical properties using SwissADME and toxicity using the ProTox II online program. This analysis confirmed the molecule's safety for therapeutic use. ChemDraw 12.0 was used to build metabolite-profiled compounds. Avogadro 1.2. 0 was utilized to optimize geometry, while PyRx 0.8 was used for Autodock Vina molecular docking. Agonist-TLR2 interactions were examined using docking results from Biovia Discovery Studio 2021. Tethering is valid; the program can be used because the RMSD is less than 2. The results showed that 6 of the 84 metabolite-profiled compounds were antagonistic to 3A7B and shared similar pharmacophore distances and amino acid linkages with N-acetyl-D-glucosamine, a native ligand of 3A7B. By binding to TLR2, the compounds from the ethyl acetate fraction of M. crenata leaves may potentially inhibit PD progression.
Trends in Incidence and Survival of 1496 Patients with Mucosal Melanoma in The Netherlands (1990–2019)

Simple Summary Mucosal melanoma (MM) is rare and entails a poor prognosis. MM is biologically different from cutaneous melanoma (CM). For advanced CM, overall survival has improved since the introduction of immune and targeted therapy. In contrast, little is known about the effect of their introduction on the survival of MM. This study presents the incidence, clinical characteristics, treatment characteristics, and survival of MM over 30 years (1990–2019) in the Netherlands. We conclude that the incidence of MM remained stable, and survival has slightly improved when comparing the timeframe 2014–2019 with previous years. However, the prognosis of MM remains poor as compared to CM. Future studies addressing the effect of immune and targeted therapy in MM are needed to improve outcomes for patients with MM. Abstract Background: Mucosal melanoma (MM) is a rare tumour with a poor prognosis. Over the years, immune and targeted therapy have become available and have improved overall survival (OS) for patients with advanced cutaneous melanoma (CM). This study aimed to assess trends in the incidence and survival of MM in the Netherlands against the background of new effective treatments that became available for advanced melanoma. Methods: We obtained information on patients diagnosed with MM during 1990–2019 from the Netherlands Cancer Registry. The age-standardized incidence rate and estimated annual percentage change (EAPC) were calculated over the total study period. OS was calculated using the Kaplan–Meier method. Independent predictors for OS were assessed by applying multivariable Cox proportional hazards regression models. Results: In total, 1496 patients were diagnosed with MM during 1990–2019, mostly in the female genital tract (43%) and the head and neck region (34%). The majority presented with local or locally advanced disease (66%). The incidence remained stable over time (EAPC 3.0%, p = 0.4). The 5-year OS was 24% (95%CI: 21.6–26.0%) with a median OS of 1.7 years (95%CI: 1.6–1.8). Age ≥ 70 years at diagnosis, higher stage at diagnosis, and respiratory tract location were independent predictors for worse OS. Diagnosis in the period 2014–2019, MM located in the female genital tract, and treatment with immune or targeted therapy were independent predictors for better OS. Conclusion: Since the introduction of immune and targeted therapies, OS has improved for patients with MM. However, the prognosis of MM patients is still lower compared to CM, and the median OS of patients treated with immune and targeted therapies remains fairly short. Further studies are needed to improve outcomes for patients with MM.
Microbiota alteration of Chinese young male adults with high-status negative cognitive processing bias

Introduction Evidence suggests that negative cognitive processing bias (NCPB) is a significant risk factor for depression. The microbiota–gut–brain axis has been proven to be a contributing factor to cognitive health and disease. However, the connection between microbiota and NCPB remains unknown. This study mainly sought to explore the key microbiota involved in NCPB and the possible pathways through which NCPB affects depressive symptoms. Methods Data in our studies were collected from 735 Chinese young adults through a cross-sectional survey. Fecal samples were collected from 35 young adults with different levels of NCPB (18 individuals were recruited as the high-status NCPB group, and another 17 individuals were matched as the low-status NCPB group) and 60 with different degrees of depressive symptoms (27 individuals were recruited into the depressive symptom group, as D group, and 33 individuals were matched into the control group, as C group) and analyzed by the 16S ribosomal RNA sequencing technique. Results As a result, the level of NCPB correlated with the degree of depressive symptoms as well as anxiety symptoms and sleep quality (p < 0.01). The β-diversity of microbiota in young adults was proven to be significantly different between the high-status NCPB and the low-status NCPB groups. There were several significantly increased bacteria taxa, including Dorea, Christensenellaceae, Christe -senellaceae_R_7_group, Ruminococcaceae_NK4A214_group, Eggerthellaceae, Family-XIII, Family_XIII_AD3011_group, Faecalibaculum, and Oscillibacter. They were mainly involved in pathways including short-chain fatty acid (SCFA) metabolism. Among these variable bacteria taxa, Faecalibaculum was found associated with both NCPB and depressive symptoms. Furthermore, five pathways turned out to be significantly altered in both the high-status NCPB group and the depressive symptom group, including butanoate metabolism, glyoxylate and dicarboxylate metabolism, propanoate metabolism, phenylalanine, tyrosine, and tryptophan biosynthesis, valine, leucine, and isoleucine degradation. These pathways were related to SCFA metabolism. Discussion Fecal microbiota is altered in Chinese young male adults with high status NCPB and may be involved in the biochemical progress that influences depressive symptoms.
Who seeks psychodynamic psychotherapy in community-based practices? Patient characteristics examined in a large sample of applications for reimbursement of psychotherapy in Germany

This study examined the demographic characteristics of patients using outpatient psychodynamic psychotherapy and compared them to the general population. A second aim was to explore clinical and biographical features of the users. We extracted data from a random sample of 983 applications for reimbursement of psychodynamic psychotherapy in community-based practices in Germany. These applications contain information for the health insurer but also additional written reports for an expert reviewer. Census data for comparison were obtained from the Federal Statistical Office of Germany. Men, older people, and migrants were underrepresented, while the unemployed were overrepresented compared to the general population. A third of the reports described a patient’s experience of physical and/or sexual violence. Twenty-six percent of the reports mentioned that the parents had separated, and a third of these patients were younger than 5 years at that time. Suicidal ideation was reported for a fifth of the patients. About 5% were reported to present with self-harming behaviour and 14% with violence towards others. It was mentioned that the patients were consuming dangerous amounts of alcohol in 9%. The most frequent diagnosis group was affective disorders, followed by neurotic disorders, whereas only few had a substance use diagnosis or a psychotic disorder. In summary, men, migrants, older people, and patients with substance abuse and psychotic disorders are likely underrepresented in outpatient psychotherapy in Germany, indicating unequal access to mental health care despite the universal coverage of its costs. Patients in outpatient psychodynamic psychotherapy often present with severe clinical problems.
Oscillator strengths and effective collision strengths for electron excitation of Mg VI

Aims. Electron impact excitation collision strengths and oscillator strengths for the astrophysically important lines in Mg VI are reported. Thermally averaged collision strengths are presented as a function of electron temperature for application to solar and other astrophysical plasmas. Methods. The collision strengths were calculated in a close-coupling approximation using the B-spline Breit-Pauli R-matrix method. The multiconfiguration Hartree-Fock method with term-dependent, non-orthogonal orbitals was employed for an accurate representation of the target wave functions. The close-coupling expansion includes 74 bound levels of Mg VI covering the n = 2a ndn = 3t erms. The present calculations led to a total of 2701 forbidden, intercombination, and allowed transitions between fine-structure levels. The effective collision strengths were obtained by averaging the electron collision strengths over a Maxwellian distribution of velocities. Results. The accuracy of present oscillator strengths is evaluated by the agreement between the length and velocity formulations combined with the agreement between the calculated and measured excitation energies. The calculated excitation energies are in excellent agreement with experiments and other extensive configuration-interaction calculations. The oscillator strengths for all E1 transitions are listed. The effective collision strengths are tabulated for all 2701 transitions among the 74 fine-structure levels at 11 electron temperatures in the range from 10000 to 200000 K. The present results are compared with other close-coupling and distorted-wave calculations. Overall good agrement is generally found with the calculations by Ramsbottom & Bell and by Landi & Bhatia for many transitions, but significant differences are also noted for some transitions.