Miracle-dz/UniFAR-FTUs huggingface dataset:
SEMIONOTIDAE (PISCES, HOLOSTEI, SEMIONOTIFORMES) DE LA FORMACION LAGARCITO (JURASICO SUPERIOR?), SAN LUIS, ARGENTINA

"Dans cet travail nous decrivons Neosemionotus nov. gen. interrnediaire entre Semionotus et Lepidotes, et un exemplaire juvenile du genre Lepidotes. L'age geologique correspond probablement au Jurassic superieur deduite de la presence des reptiles de l'ordre Pterosauria, mais il est possible que les depouilles soient du Cretacique"
Stem cell topography splits growth and homeostatic functions in the fish gill

While lower vertebrates contain adult stem cells (aSCs) that maintain homeostasis and drive un-exhaustive organismal growth, mammalian aSCs display mainly the homeostatic function. Here, we use lineage analysis in the medaka fish gill to address aSCs and report separate stem cell populations for homeostasis and growth. These aSCs are fate-restricted during the entire post-embryonic life and even during re-generation paradigms. We use chimeric animals to demonstrate that p53 mediates growth coordination among fate-restricted aSCs, suggesting a hierarchical organisation among lineages in composite organs like the fish gill. Homeostatic and growth aSCs are clonal but differ in their topology; modifications in tissue architecture can convert the homeostatic zone into a growth zone, indicating a leading role for the physical niche defining stem cell output. We hypothesise that physical niches are main players to restrict aSCs to a homeostatic function in animals with fixed adult size.
REFLECTOR USE AND THE EFFECT THEY HAVE ON THE NUMBER OF MULE DEER KILLED ON CALIFORNIA HIGHWAYS. FINAL REPORT

The "Swareflex" wildlife warning system was tested to determine if it would reduce the number of mule deer killed on the highway. The test area was located on a four-mile section of State Route 36 east of Chester in Plumas County, California. This section of highway was chosen due to a history of extremely high deer kill. After three seasons, it has been determined there is no statistical difference in the mean of the deer killed when the reflectors were in operation and when they were not operating.
Endothelin receptor Aa regulates proliferation and differentiation of Erb-dependant 1 pigment progenitors in zebrafish 2

17 Skin pigment patterns are important, being under strong selection for multiple roles 18 including camouflage and UV protection. Pigment cells underlying these patterns form 19 from adult pigment stem cells (APSCs). In zebrafish, APSCs derive from embryonic neural 20 crest cells, but sit dormant until activated to produce pigment cells during metamorphosis. 21 The APSCs are set-aside in an ErbB signaling dependent manner, but the mechanism 22 maintaining quiescence until metamorphosis remains unknown. Mutants for a pigment 23 pattern gene, parade, exhibit ectopic pigment cells localised to the ventral trunk. We show 24 that parade encodes Endothelin receptor Aa, expressed in the blood vessels. Using 25 chemical genetics, coupled with analysis of cell fate studies, we show that the ectopic 26 pigment cells derive from APSCs. We propose that a novel population of APSCs exists in 27 association with medial blood vessels, and that their quiescence is dependent upon 28 Endothelin-dependent factors expressed by the blood vessels. 29 . CC-BY-NC-ND 4.0 International license It is made available under a (which was not peer-reviewed) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. The copyright holder for this preprint . http://dx.doi. org/10.1101/308221 doi: bioRxiv preprint first posted online Apr. 25, 2018;
The characterization of hybrid PLC-wireless and PLC channels in the frequency band between 1.7 and 100 MHz for data communication

Essa tese de doutorado apresenta, inicialmente, uma metodologia a ser empregada para a caracterizacao de redes de energia eletrica para fins de comunicacao de dados. Esta metodologia engloba todos os procedimentos e ferramentas de processamento de sinais necessarias para a estimacao de caracteristicas importantes para a avaliacao de canais de comunicacao de dados. Em seguida, sao apresentados resultados da aplicacao de tal metodologia em dados provenientes de uma campanha de medicao realizada em ambientes internos em residencias brasileiras. Algumas caracteristicas importantes desses canais, tais como ganho medio, banda de coerencia, tempo de coerencia, o valor quadratico medio do espalhamento de atraso, capacidade do canal e densidade espectral de potencia do ruido, sao analizadas considerando tres bandas de frequencia: de 1,7 ate 30 MHz, de 1,7 ate 50 MHz e de 1,7 ate 100 MHz. Comparando os resultados de canais power line communication (PLC) em ambientes residenciais brasileiros com aqueles medidos em outros paises, tais como Espanha, Estados Unidos, Franca e Italia, podemos notar que canais PLC brasileiros apresentam, em geral, menores atenuacoes, sao menos seletivos em frequencia e possuem menores espalhamentos de atraso. Por fim, um novo meio de comunicacao baseada nas tecnologias PLC e sem fio e apresentada e definida como hibrido PLC-sem fio o qual permite a comunicacao fisica e a distância com a rede de energia eletrica para fins de comunicacao de dados. Tal canal de comunicacao e avaliado em residencias brasileiras e importantes caracteristicas sao extraidas e discutidas. Embora o canal hibrido PLC-sem fio tenha se mostrado mais adverso que o canal PLC para a comunicacao de dados, a introducao da mobilidade, de uma forma que e impossivel de se obter em sistemas puramente PLC, constitui sua principal vantagem. Essa mobilidade e um importante atrativo que coloca sistemas hibridos em uma posicao privilegiada dentre os candidatos para compor a infraestrutura de telecomunicacoes em redes inteligentes (smart grids), ou para ser usada como uma ferramenta para promover a inclusao digital da populacao carente de paises pobres ou em desenvolvimento.
Oxidative/antioxidative status, lymphocyte DNa damage, and urotensin-2 receptor level in patients with migraine attacks

Background: The present study investigated the potential roles of plasma lymphocyte DNA damage, the urotensin-2 receptor (UTS2R), and oxidative changes in patients with varying degrees of migraine-related disability who were in the ictal phase and presented to our emergency department. Methods: This study enrolled 40 consecutive adult patients with migraine attack and 40 age- and sex-matched healthy controls. The same health care professional determined the headache-related disability of each patient’s migraine attack using the Migraine Disability Assessment Scale (MIDAS); patients were divided into three groups based on MIDAS score. Plasma lymphocyte DNA damage; UTS2R, malondialdehyde (MDA), and catalase (CAT) levels; total oxidant status (TOS); total antioxidant status (TAS); and the oxidative stress index (OSI) were used as predictors of early oxidative changes. Results: Plasma lymphocyte DNA damage, TOS, MDA levels, and OSI values were significantly higher in patients with migraine compared to controls. Conversely, TAS and CAT and UTS2R levels were markedly lower in patients with migraine compared to controls. Comparisons of the patient groups by MIDAS score revealed significant differences in plasma lymphocyte DNA damage and CAT levels but no differences in TOS, MDA levels, OSI, TAS, or UTS2R levels. MIDAS scores were positively correlated with the degree of lymphocyte DNA damage, but neither of these factors was significantly related to CAT levels. Conclusion: The present data suggest that lymphocyte DNA damage and changes in oxidative/ antioxidative status may reflect an enhanced oxidative damage and an ineffective antioxidant defense system in migraineurs during headache attacks. In addition, lymphocyte DNA damage levels may be an indicator of the degree of migraine-related disability as assessed by MIDAS score.
Citrate versus heparin anticoagulation in chronic haemodialysis patients.

Anticoagulation with citrate at a rate of 0.68 mM/min in combination with a calcium and magnesium-free dialysate and i.v. supplementation of calcium and magnesium at rates of 0.18 mM/min and 0.08 mM/min respectively, was compared with low-dose heparin. The heparin dose was a loading dose of 2500 IU and a sustaining infusion of 750-1250 IU/h; or a loading dose of 1250 IU and a sustaining infusion of 500-750 IU/h until 1 h before the end of the dialysis if the patient was taking concomitantly coumarin anticoagulation for a Goretex shunt. Six chronic haemodialysis patients changed from heparin to citrate anticoagulation because they reported bleeding between dialyses. Heparin, after 2 h dialysis, induced a significant 10% prolongation of each patient's whole-blood activated clotting time (WBACT) as compared to the predialysis value; while the WBACT at the dialyser outlet was less than 3% prolonged as compared to the patient's WBACT. However, after 2 h citrate the patient's WBACT was not prolonged but the WBACT at the dialyser outlet was 20-100% longer, indicating a better anticoagulation of the extracorporeal system without systemic effects. With heparin the shunt pressure time (SPT), i.e. the time needed to stop bleeding from the puncture sites of the Goretex shunts, was 12 of 28 times 20 min or more. Citrate reduced these episodes by 75%. Thus citrate should be considered for chronic haemodialysis patients who are at risk of bleeding because of the concomitant use of anticoagulants. (ABSTRACT TRUNCATED AT 250 WORDS)
Metagenomic analysis reveals the impact of wastewater treatment plants on the 1 dispersal of microorganisms and genes in aquatic sediments 2

28 Wastewater treatment plants (WWTPs) release treated effluent containing mobile genetic 29 elements (MGEs), antibiotic resistance genes (ARGs) and microorganisms into the 30 environment, yet little is known about their influence on nearby microbial communities and 31 the retention of these factors in receiving water bodies. Our research aimed to characterize 32 the genes and organisms from two different WWTPs that discharge into Lake Michigan, as 33 well as from surrounding lake sediments to determine the dispersal and fate of these factors 34 with respect to distance from the effluent outfall. Shotgun metagenomics coupled to distance- 35 decay analyses showed a higher abundance of genes identical to those in WWTP effluent 36 genes in sediments closer to outfall sites than in sediments farther away, indicating their 37 possible WWTP origin. We also found genes attributed to organisms such as 38 Helicobacteraceae , Legionellaceae , Moraxellaceae , and Neisseriaceae in effluent from both 39 WWTPs and decreasing in abundance in lake sediments with increased distance from 40 WWTPs. Moreover, our results showed that the WWTPs likely influence the ARG 41 composition in lake sediments close to the effluent discharge. Many of these ARGs were 42 located on MGEs in both the effluent and sediment samples, indicating relatively broad 43 propensity for horizontal gene transfer (HGT). Our approach allowed us to specifically link 44 genes to organisms and their genetic context, providing insight into WWTP impacts on 45 natural microbial communities. Overall, our results suggest a substantial influence of 46 wastewater effluent on gene content and microbial community structure in sediments of 47 receiving water bodies. Although treated, effluent retains many genes and microorganisms that have the potential to influence the receiving water in ways that are poorly understood. Here, we tracked the genetic footprint, including genes specific to antibiotic resistance and mobile genetic 53 elements and their associated organisms, from WWTPs to lake sediments. Our work is novel in that we used metagenomic datasets to comprehensively evaluate total gene content and the genetic and taxonomic context of specific genes in environmental samples putatively 56 impacted by WWTP inputs. Based on two different WWTPs with different treatment processes, our findings point to an influence of WWTPs on the presence, abundance, and 58 composition of these factors in the environment. metagenomes of WWTP to which Our results corroborate previous studies showing a higher abundance of specific ARGs in sites around WWTPs than in sediment or water from sites farther away 26, 27) and significantly extend our knowledge of WWTPs on gene content and organisms beyond just ARGs.
Comparison of arterial pressure and plethysmographic waveform-based dynamic preload variables in assessing fluid responsiveness and dynamic arterial tone in patients undergoing major hepatic resection.

BACKGROUND Dynamic preload variables to predict fluid responsiveness are based either on the arterial pressure waveform (APW) or on the plethysmographic waveform (PW). We compared the ability of APW-based variations in stroke volume (SVV) and pulse pressure (PPV) and of PW-based plethysmographic variability index (PVI) to predict fluid responsiveness and to track fluid changes in patients undergoing major hepatic resection. Furthermore, we assessed whether the PPV/SVV ratio, as a measure of dynamic arterial elastance (Eadyn), could predict a reduction in norepinephrine requirement after fluid administration. METHODS Thirty patients received i.v. fluid (15 ml kg(-1) in 30 min) after hepatic resection and were considered responders when stroke volume index (SVI) increased ≥20% after fluid administration. SVV and SVI were measured by the FloTrac-Vigileo(®) device, and PVI was measured by the Masimo Radical 7 pulse co-oximeter(®). RESULTS The areas under a receiver operating characteristic curve for SVV, PPV, and PVI were 0.81, 0.77, and 0.78, respectively. In responders, all dynamic variables, except PVI, decreased after fluid administration. Eadyn predicted a reduced norepinephrine requirement (AUC = 0.81). CONCLUSIONS In patients undergoing major hepatic resection, both APW- and PW-based dynamic preload variables predict fluid responsiveness (preload) to a similar extent. Most variables (except PVI) also tracked fluid changes. Eadyn, as a measure of arterial elastance (afterload), might be helpful to distinguish the origin of hypotension. CLINICAL TRIAL REGISTRATION ClinicalTrials.gov, NCT01060683.
Outbreak of Seoul Virus Among Rats and Rat Owners — United States and Canada, 2017

In December 2016, the Wisconsin Department of Health Services (WDHS) notified CDC of a patient hospitalized with fever, leukopenia, elevated transaminases, and proteinuria. The patient owned and operated an in-home rattery, or rat-breeding facility, with approximately 100 Norway rats, primarily bred as pets. A family member developed similar symptoms 4 weeks later, but was not hospitalized. Because both patients were known to have rodent contact, they were tested for hantavirus infections. In January 2017, CDC confirmed recent, acute Seoul virus infection in both patients. An investigation was conducted to identify additional human and rat infections and prevent further transmission. Ultimately, the investigation identified 31 facilities in 11 states with human and/or rat Seoul virus infections; six facilities also reported exchanging rats with Canadian ratteries. Testing of serum samples from 183 persons in the United States and Canada identified 24 (13.1%) with Seoul virus antibodies; three (12.5%) were hospitalized and no deaths occurred. This investigation, including cases described in a previously published report from Tennessee (1), identified the first known transmission of Seoul virus from pet rats to humans in the United States and Canada. Pet rat owners should practice safe rodent handling to prevent Seoul virus infection (2).
Stereotactic Radiosurgery and Stereotactic Body Radiation Therapy for Tumors Outside of Intracranial , Skull Base , or Orbital Sites Effective : August 1 , 2019

PLEASE NOTE: Contracts exclude from coverage, among other things, services or procedures that are considered investigational or cosmetic. Providers may bill members for services or procedures that are considered investigational or cosmetic. Providers are encouraged to inform members before rendering such services that the members are likely to be financially responsible for the cost of these services.
short-term outcomes of combined pars plana vitrectomy for epiretinal membrane and phacoemulsification surgery with multifocal intraocular lens implantation

Purpose: The purpose of this study was to evaluate the functional and anatomical outcomes of combined phacovitrectomy with multifocal intraocular lens (mfIOL) implantation. Methods: Retrospective, interventional, non-comparative case series of six eyes that received a combined phacoemulsification surgery with apodized, diffractive mfIOL implantation for cataract and pars plana vitrectomy (PPV) with membrane peeling for epiretinal membrane (ERM). Outcome measures included distance and near visual acuities (DVA and NVA), central macular thickness (CMT), intraocular pressure (IOP), and disruption of external limiting membrane (ELM) or inner-segment outer-segment (IS/OS) junction. Results: Mean logMAR glare DVA improved from 0.40 (Snellen 20/50) preoperatively to a mean uncorrected DVA of 0.038 (Snellen 20/22) ( P = 0.004) at 6 months after surgery. All eyes achieved NVA of J2 or better by 12 months postoperatively. Median CMT improved by 10 µ m and mean IOP increased by 1 mmHg at 12 months postoperatively. Percentage of patients with ELM or IS/OS disruptions decreased from 66.7% to 33.3%. Two eyes demonstrated residual metamorphopsia on Amsler grid testing postoperatively. Postoperatively, four eyes required laser capsulotomy and one required LASEK for refractive correction. Conclusion: Combined phacovitrectomy, membrane peeling, and mfIOL implantation improved VA in patients with idiopathic ERM. Multifocality was achieved, but final visual outcome was delayed due to posterior capsular opacification and macular healing.
Structural characterization of human milk oligosaccharides (HMOs) using ultra-high performance liquid chromatography-helium charge transfer dissociation mass spectrometry (UHPLC-he-CTD-MS).

The combination of helium charge transfer dissociation mass spectrometry (He-CTD-MS) with ultra-high performance liquid chromatography (UHPLC) is presented for the analysis of a complex mixture of acidic and neutral human milk oligosaccharides (HMOs). The research focuses on the identification of the monosaccharide sequence, the branching patterns, sialylation/fucosylation arrangements, and the differentiation of isomeric oligosaccharides in the mixture. Initial studies first optimized the conditions for the UHPLC separation and the He-CTD-MS conditions. Results demonstrate that He-CTD is compatible with UHPLC timescales and provides unambiguous glycosidic and cross-ring cleavages from both the reducing and the non-reducing ends, which is not typically possible using collision-induced dissociation (CID). He-CTD produces informative fragments, including 0,3An and 0,4An ions, which have been observed with electron transfer dissociation (ETD), electron detachment dissociation (EDD), and ultraviolet photodissociation (UVPD) and are crucial for differentiating the α-2,3- vs α-2,6-linked sialic acid (Neu5Ac) residues present among sialyllacto-N-tetraose HMOs. In addition to the linkage positions, He-CTD is able to differentiate structural isomers for both sialyllacto-N-tetraoses and lacto-N-fucopentaoses structures by providing unique, unambiguous cross ring cleavages of types 0,2An, 0,2Xn and 1,5An while preserving most of the labile Neu5Ac and fucose groups.
Globus pharyngeus

Globus pharyngeus is a very common problem to confront the ENT surgeon, comprising some 3 per cent of all new clinic referrals (Moloy and Charter, 1982; Flores et al., 1981). It was recognised by Hippocrates, but was first well described in 1707 by John Purcell. Of the condition he said: 'These symptoms are not the vain imaginations and groundless fancies occasioned by the disturbance of the spirits of the brain, but are real sensations actually felt by the patient. '
Analysis the pathogenic gene of 60 Chinese children with congenital hyperinsulinemia Running title : Analysis of congenital hyperinsulinemia

This study aims to summarize and analyze the clinical manifestations, genetic characteristics, treatment modalities and long-term prognosis of congenital hyperinsulinemia (CHI) in Chinese children. Sixty children with CHI, who were treated at Beijing Children's Hospital from January 2014 to August 2017, and their families, were selected as subjects. The CHI-related causative genes in children were sequenced and analyzed using second-generation sequencing technology. Furthermore, the genetic pathogenesis and clinical characteristics of Chinese children with CHI were explored. Among the 60 CHI children, 27 children (27/60, 45%) carried known CHI-related gene mutations: 16 children (26.7%) carried ABCC8 gene mutations, seven children (11.7%) carried GLUD1 gene mutations, one child carried GCK gene mutations, two children carried HNF4α gene mutations and one child carried HADH gene mutations. In these 60 patients, 8 patients underwent 18F-L-DOPA PET scan for the pancreas, and five children were found to be focal type. The treatment of diazoxide was ineffective in these five patients, and hypoglycemia could be controlled after receiving partial pancreatectomy. Conclusions: ABCC8 gene mutation is the most common cause of CHI in Chinese children. The early genetic analysis of children's families has an important guiding significance for treatment planning and Page 2 of 36 Accepted Manuscript published as EC-18-0240.R1. Accepted for publication: 05-Oct-2018 Copyright © 2018 the authors Downloaded from Bioscientifica.com at 10/15/2018 09:51:37PM via free access prognosis assessment.
cytoprotective effects of molsidomine against methotrexate-induced hepatotoxicity: an experimental rat study

Introduction aim: Methotrexate (Mtx) is an antineoplastic and immunosuppressive drug that may cause hepatotoxicity, whereas molsidomine (Mol) is a vasodilating and antioxidant agent. This study aimed to investigate the potential protective effects of Mol in Mtx-induced liver toxicity in rats. Materials and methods: Forty Wistar albino rats were equally divided into five groups: control, Mol, Mtx, Mol–Mtx, and Mtx–Mol. Following treatment, the animals were sacrificed, and liver tissue samples were histopathologically evaluated using Roening grading and Bcl-2 antibody staining. Tissue oxidants, antioxidants, and serum transaminases were measured and statistically compared across all groups. Results: No hepatic fibrosis or steatosis was observed in any of the groups. In the Mtx group, grade 2 liver injury and score 2 Bcl-2 antibody staining were observed; however, in the Mol–Mtx group, these were lower (grade 1, score 1). There were no statistically significant differences in serum transaminase levels among groups. Malondialdehyde levels were higher in all rats that received Mtx, but no differences in myeloperoxidase levels were observed among the groups. Levels of tissue antioxidants, including superoxide dismutase, glutathione (GSH) peroxidase (GSH-Px), and reduced GSH, were significantly higher in the Mol-treated and Mol pre-treated groups. Catalase (CAT) levels were elevated in all Mol-treated groups, but only in that group were CAT levels statistically significantly higher than in the control group. Conclusion: Our results suggest that some oxidant levels could increase following Mtx administration in the liver, possibly contributing to liver damage, whereas Mol could mitigate the histopathological and biochemical effects of hepatotoxicity. However, molecular studies are required to understand the exact mechanisms of these alterations.