Miracle-dz/UniFAR-FTUs huggingface dataset:
MOOC on "Ultra-dense Networks for 5G and its Evolution": Challenges and Lessons Learned

Many of the new mobile communication devices will be things that power and monitor our homes, city infrastructure and transport. Controlling drones thousands of miles away, performing remote surgeries or being immersed in video with no latency will also be a huge game changer. Those are some of the few things that make the fifth generation (5G) a revolution expected to be a thrust to the economy. To that end, the design and density of deployment of new networks is also changing becoming more dense, what introduces new challenges into play. What else will it add to previous generations? The MOOC about Ultra-dense networks for 5G and its evolution has been prepared by the researchers of an European MSCA ITN, named TeamUp5G, and introduces the most important technologies that support 5G mobile communications, with an emphasis on increasing capacity and reducing power. The content spans from aspects of communication technologies to use cases, prototyping and the future ahead, not forgetting issues like interference management, energy efficiency or spectrum management. The aim of the MOOC is to fill the gap in graduation and post-graduation learning on content related to emerging 5G technologies and its applications, including the future 6G. The target audience involves engineers, researchers, practitioners and students. This paper describes the content and the learning outcomes of the MOOC, the main tasks and resources involved in its creation, the joint contributions from the academic and non-academic sector, and aspects like copyright compliance, quality assurance, testing and details on communication and enrollment, followed by the discussion of the lessons learned.
Measurement of Company Performance Based on Innovation (Study on Restaurant and Cafe in Padang City)

This study aims to analyze the role of product innovation, process innovation and organizational innovation on company performance in restaurant and cafe businesses in Padang City. This explanatory research uses surveys, explanatory surveys with a quantitative approach. Data collection on 136 restaurant and cafe business actors in the city of Padang was carried out using the purposive sampling technique. The data were then analyzed using Structural Equation Modeling - Partial Least Square (SEM-PLS). The results show that product innovation has a significant effect on company performance, process innovation has a significant effect on product innovation, process innovation has no significant effect on company performance, organizational innovation has a significant effect on process innovation, and organizational innovation has a significant effect on company performance. This study has several important findings for restaurants and cafes in the city of Padang, to pay more attention to the innovations carried out in their business, especially process innovation and organizational innovation, because process innovation significantly affects product innovation of restaurant and cafe business actors in the city of Padang. Furthermore, organizational innovation significantly affects process innovation, and the performance of restaurant and cafe business actors in the city of Padang.
Longevity and rejuvenation effects of cell reprogramming are decoupled from loss of somatic identity

Partial somatic cell reprogramming has been touted as a promising rejuvenation strategy. However, its association with mechanisms of aging and longevity at the molecular level remains unclear. We identified a robust transcriptomic signature of reprogramming in mouse and human cells that revealed co-regulation of genes associated with reprogramming and response to lifespan-extending interventions, including those related to DNA repair and inflammation. We found that age-related gene expression changes were reversed during reprogramming, as confirmed by transcriptomic aging clocks. The longevity and rejuvenation effects induced by reprogramming in the transcriptome were mainly independent of pluripotency gain. Decoupling of these processes allowed predicting interventions mimicking reprogramming-induced rejuvenation (RIR) without affecting somatic cell identity, including an anti-inflammatory compound osthol, ATG5 overexpression, and C6ORF223 knockout. Overall, we revealed specific molecular mechanisms associated with RIR at the gene expression level and developed tools for discovering interventions that support the rejuvenation effect of reprogramming without posing the risk of neoplasia.
Study of Three Potential Diagnostic Biomarkers in Nasopharyngeal Carcinoma Samples from Guilan, North of Iran

Abstract Introduction Finding biomarkers for highly lethal cancers is a priority. Objective The current study was designed to understand the clinical significance of vascular endothelial growth factor (VEGF), latent membrane protein 1 (LMP1), and tumor necrosis factor-α (TNF-α) expression as the biomarkers, and evaluate their correlation with each other, in nasopharyngeal carcinoma (NPC) in the province of Guilan, North of Iran. Methods Gene expression was evaluated in 25 formalin-fixed paraffin-embedded (FFPE) blocks from cases of confirmed NPC and 20 FFPE samples of non-NPC by quantifying messenger ribonucleic acid (mRNA) and protein levels, using real-time polymerase chain reaction (PCR) and immunohistochemistry (IHC) methods, respectively. Furthermore, the correlations among the protein levels of different genes, along with the patients' demographic characteristics were assessed. Results Our findings on mRNA and protein levels demonstrated that the expression of the LMP1 gene in the NPC group was significantly elevated compared with that of the non-NPC group. In addition, the protein levels in the NPC group indicated a positive and significant correlation between LMP1 and VEGF expression. It was noted that both protein and mRNA levels showed no significant differences in the expression of TNF-α and VEGF genes between the NPC and control groups. Furthermore, there was no significant relationship between the expression of these proteins and the demographic characteristics of NPC patients. Conclusion Overall, a significant increase in LMP1 expression was observed in NPC patients, which may serve as a diagnostic biomarker for NPC. Also, LMP1 might be involved in NPC progression by inducing VEGF gene expression.
Anti-Inflammatory and Antioxidant Effects of Carvacrol on N-Methyl-N′-Nitro-N-Nitrosoguanidine (MNNG) Induced Gastric Carcinogenesis in Wistar Rats

Carvacrol is a dietary polyphenol from Lamiaceae plants that has been shown to possess a wide range of biological activities including antioxidant and antitumor effects. This study aimed to investigate its anti-inflammatory and antioxidant effects on N-methyl-N′-nitro-N-nitrosoguanidine (MNNG) induced gastric carcinogenesis in Wistar rats. Forty-nine rats were randomly assigned to four treatment and three control groups. Over 60 days, MNNG (200 mg/kg BW) was orally applied to animals of groups 1–5 while the rats in groups 2–5 also received different doses of carvacrol (10, 25, 50, and 100 mg/kg BW, respectively) until the end of the experiment. Group 6 rats were treated with 100 mg/kg BW carvacrol and no MNNG whereas group 7 was the control group without any treatment. After the euthanasia of all rats, the inflammatory cytokines and oxidative stress parameters were assessed in the blood and tissues. The expression of caspase 9, Bax, and Bcl-2 proteins in the stomach tissues were investigated through histopathological examinations. Statistically significant differences were observed in the body weight, oxidative stress, and inflammation parameters of groups 1 to 6 compared to group 7 (p ≤ 0.001). Animals in MNNG groups 2 and 3 treated with the low dose carvacrol (10 and 25 mg/kg BW) showed significantly reduced oxidative stress, inflammation, and apoptotic effect compared to animals of the MNNG groups receiving increased doses of carvacrol (50 and 100 mg/kg BW) or no carvacrol. Rats exposed to MNNG exhibited gastric cancer cells in several areas. In the MNNG group receiving 100 mg/kg BW carvacrol, the inflammatory cell infiltration was observed in gastric mucosal and submucosal areas whereas MNNG rats supplemented with 10 and 25 mg/kg BW carvacrol showed no pathological alterations of the gastric cells. The results of this study indicate that significant antioxidant and anti-inflammatory effects induced by carvacrol at doses of 10 and 25 mg/kg BW interfered with gastric carcinogenesis induced by MNNG in Wistar rats as well as provide hepatoprotection. However, high doses of carvacrol (50 and 100 mg/kg BW) increased oxidative stress, inflammation, and apoptosis.
Severe Immune-Related Cutaneous Vasculitis Induced by Osimertinib

Osimertinib is a third-generation epidermal growth factor receptor (EGFR)- tyrosine kinase inhibitors (TKIs) which is the current standard of care for first-line treatment of advanced EGFR+ Non-Small Cell Lung Cancer (NSCLC). The most common Osimertinib-related adverse events (AEs) are hematologic toxicity, rash, dry skin, and paronychia which are usually tolerable and manageable. Serious AEs occur infrequently and the etiopathogenesis of some remains unclear. We present a case of grade 3 cutaneous vasculitis induced by osimertinib in a Caucasian woman that required immunosuppressive therapy.
Laboratory Rat Thrombi Lose One-Third of Their Stiffness When Exposed to Large Oscillating Shear Stress Amplitudes: Contrasting Behavior to Human Clots

Rats impress by their high platelet count resulting in hypercoagulability, which protects the animals from severe bleeding. However, platelets also import numerous stiff junction points into the fibrous system of a clot, also enhancing the pre-stress of the fibrin fibers, which lowers their deformability. Clot deformation is clinically important since large strains are present in the arterial tree (caused by the propagation of pressure and pulse waves), and a clot is considered “safe” when it can deform over a long range of strain amplitudes. We tested clot formation and the behavior of fully formed blood clots of laboratory rats at large sinusoidal shear stress amplitudes by rheometry and compared outcomes to human reference data. We found that fiber density (by scanning electron microscopy) and clot stiffness was pronounced compared to humans and differed with sexual dimorphism and with rat strain. Using our large amplitude oscillation (LAOS) protocol, we detected that rat clots yielded with a frustrated attempt to stiffen instead of showing the macroscopic stiffening response that is typical for human clots. We attribute this behavior to the appearance of multiple microfractures until, finally, a few leading fibers uptake the load. Rat clots also failed to align fibers in shear direction to initiate affine deformation. The rat clot phenotype differs substantially from the human one, which must be considered in research and toxicological testing. If microfractures in the fiber meshwork are concentrated in vivo, parts of a clot may break off and be washed away. However, homogenously distributed microfractures may open pores and allow the penetration of plasminogen activators. What occurs in the rat vasculature depends on the on-site clot composition.
Liquefaction potential of reinforced sand with plastic wastes

: Granular soil liquefaction, due to developed pore water pressure during undrained cyclic shear 60 of saturated soils, is regarded as a common phenomenon under earthquakes loading. This phenomenon 61 results in the huge damage to infrastructures. Various reinforcement materials have been successfully 62 implemented with particular attention to use waste materials to satisfy design specifications and also 63 reducing the adverse environmental effects. This paper investigates the possibility of using waste plastic 64 fibers as a reinforcement material to mitigate liquefaction potential and pore pressure generation of 65 reinforced sand under cyclic loading. For this purpose, 42 stress-controlled cyclic triaxial tests were 66 conducted on Babolsar sand, reinforced by polyethylene terephthalate (PET) and polypropylene (PP) 67 fibers with fiber contents of 0.25%, 0.5% and 1%, under confining pressures of 50, 100 and 200 kPa, and 68 with cyclic stress ratios (CSR) of 0.2 and 0.35. Results revealed that the addition of these waste plastic 69 fibers could significantly increase the liquefaction resistance of Babolsar sand, and also, with an increase 70 in the waste content, the number of cycles leading to liquefaction increased. Adding wastes decreased the 71 pore water pressure generation, and this effect was more pronounced with an increase in the waste 72 content. 73
G-Quadruplex Formed by the Promoter Region of the hTERT Gene: Structure-Driven Effects on DNA Mismatch Repair Functions

G-quadruplexes (G4s) are a unique class of noncanonical DNAs that play a key role in cellular processes and neoplastic transformation. Herein, we focused on the promoter region of human TERT oncogene, whose product is responsible for the immortality of cancer cells. It has been shown by chemical probing and spectroscopic methods that synthetic 96-nt DNAs modeling the wild-type G-rich strand of the hTERT promoter and its variants with G>A point substitutions corresponding to somatic driver mutations fold into three stacked parallel G4s with sites of local G4 destabilization caused by G>A substitutions in the G4 motif. These models were used to elucidate how the hTERT multiG4 affects the binding affinity and functional responses of two key proteins, MutS and MutL, involved in the initial stage of DNA mismatch repair (MMR) in Escherichia coli and Neisseria gonorrhoeae with different MMR mechanisms. We have shown for the first time that (i) point substitutions do not affect the effective binding of these proteins to the hTERT G4 structure, and (ii) the endonuclease activity of MutL from N. gonorrhoeae is significantly suppressed by the stable G4 scaffold. It is likely that some of the genomic instability associated with G4 may be related to the blockage of human intrinsic methyl-independent MMR attempting to operate near G4 structures.
Ensemble predictions are essential for accurate bird migration forecasts for conservation and flight safety

1. Accurate predictions of the abundance of migrating birds are important to avoid aerial conflicts of birds, for example, with aviation or wind power installations. 2. Here we develop a predictive model, using bird migration intensity extracted from operational weather data. We compare baseline phenological models to models incorporating both local and remote weather conditions using an ensemble approach. Single models are compared to ensemble models (average prediction of top 10 models). The models were evaluated by omitting single years from our 10-year dataset. 3. In general, we find that wind conditions, in addition to seasonal and diurnal dynamics, are key for accurate predictions. The spring and fall migratory seasons differ, both with respect to the selected environmental variables and the contribution of the environmental model compared to the phenological model. In fall, the accumulation of migrants due to strong headwinds is an important predictor of migration. 4. Because of the lower daily variation in migration intensity in spring, the phenological model performs better compared to fall. In fall, weather conditions contribute more to accurate predictions of migration intensity than in spring. 5. Overall, the ensemble approach produces more accurate predictions outperform-ingspecificenvironmentalmodels.Wethereforerecommendthatensemblemodels be used in operational settings such as flight planning to reduce bird aircraft collisions during intense bird migration.
One-Step Synthesis of Nitrogen/Fluorine Co-Doped Carbon Dots for Use in Ferric Ions and Ascorbic Acid Detection

Carbon dots (CDs) have caught enormous attention owing to their distinctive properties, such as their high water solubility, tunable optical properties, and easy surface modification, which can be generally used for the detection of heavy metals and organic pollutants. Herein, nitrogen and fluorine co-doped carbon dots (NFCDs) were designed via a rapid, low-cost, and one-step microwave-assisted technique using DL-malic acid and levofloxacin. The NFCDs emitted intense green fluorescence under UV lighting, and the optical emission peak at 490 nm was observed upon a 280 nm excitation, with a high quantum yield of 21.03%. Interestingly, the spectral measurements illustrated excitation-independent and concentration-independent single-color fluorescence owing to the presence of nitrogen and fluorine elements in the surface functional groups. Additionally, the NFCDs were applied for the selective detection of Fe3+ and ascorbic acid based on the “turn-off” mode. The detection limits were determined as 1.03 and 4.22 µM, respectively. The quenching mechanisms were explored using the static quenching mechanism and the inner filter effect. Therefore, a NFCDs fluorescent probe with single color emission was successfully developed for the convenient and rapid detection of Fe3+ and ascorbic acid in environments.
RRM2 enhances MYCN-driven neuroblastoma formation and acts as a synergistic target with CHK1 inhibition

High-risk neuroblastoma, a pediatric tumor originating from the sympathetic nervous system, has a low mutation load but highly recurrent somatic DNA copy number variants. Previously, segmental gains and/or amplifications allowed identification of drivers for neuroblastoma development. Using this approach, combined with gene dosage impact on expression and survival, we identified ribonucleotide reductase subunit M2 (RRM2) as a candidate dependency factor further supported by growth inhibition upon in vitro knockdown and accelerated tumor formation in a neuroblastoma zebrafish model coexpressing human RRM2 with MYCN. Forced RRM2 induction alleviates excessive replicative stress induced by CHK1 inhibition, while high RRM2 expression in human neuroblastomas correlates with high CHK1 activity. MYCN-driven zebrafish tumors with RRM2 co-overexpression exhibit differentially expressed DNA repair genes in keeping with enhanced ATR-CHK1 signaling activity. In vitro, RRM2 inhibition enhances intrinsic replication stress checkpoint addiction. Last, combinatorial RRM2-CHK1 inhibition acts synergistic in high-risk neuroblastoma cell lines and patient-derived xenograft models, illustrating the therapeutic potential.
The 21-cm line at high redshift: a diagnostic for the origin of large scale structure

Les observations radio de la raie de l'hydrogene neutre a 21 cm deplacee vers le rouge peuvent etre un diagnostique efficace pour tester les theories cosmologiques. Les parametres observationnels de modeles d'explosion, de matiere sombre froide et baryonique, sont determines dans l'optique du Giant Metre-Wavelengh Radio Telescope qui va etre construit en Inde.
Medical Aspects of mTOR Inhibition in Kidney Transplantation

The advances in transplant immunosuppression have reduced substantially the incidence of kidney graft rejection. In recent years, the focus has moved from preventing rejection to preventing the long-term consequences of long-standing immunosuppression, including nephrotoxicity induced by calcineurin inhibitors (CNI), as well as infectious and neoplastic complications. Since the appearance in the late 1990s of mTOR inhibitors (mTORi), these unmet needs in immunosuppression management could be addressed thanks to their benefits (reduced rate of viral infections and cancer). However, management of side effects can be troublesome and hands-on experience is needed. Here, we review all the available information about them. Thanks to all the basic, translational and clinical research achieved in the last twenty years, we now use mTORi as de novo immunosuppression in association with CNI. Another possibility is represented by the conversion of either CNI or mycophenolate (MPA) to an mTORi later on after transplantation in low-risk kidney transplant recipients.
Wildlife Photos on Social Media: A Quantitative Content Analysis of Conservation Organisations’ Instagram Images

Simple Summary Although images are more effective than words at communicating important conservation ideas, different aspects of these images have been demonstrated to have positive and negative effects on viewers’ views towards wildlife and towards the organisation that posted the image. The most prevalent and engaging characteristics of wildlife photographs posted to Instagram in 2020 and 2021 were assessed using a quantitative content analysis, with Australian organisations as a case study. The findings show that conservation organisations can confidently share and post photographs that promote positive attitudes towards wildlife and the conservation organisation, and that Instagram posts can feature and promote a wide range of currently underrepresented species. Abstract Wildlife populations are vanishing at alarmingly high rates. This issue is being addressed by organisations around the world and when utilizing social media sites like Instagram, images are potentially more powerful than words at conveying crucial conservation messages and garnering public support. However, different elements of these images have been shown to potentially have either positive or negative effects on viewers’ attitudes and behaviours towards wildlife and towards the organisation posting the image. This study used a quantitative content analysis to assess the most common and engaging elements of wildlife images posted to Instagram in 2020 and 2021, using Australian conservation organisations as a case study. A total of 670 wildlife images from the Instagram accounts of 160 conservation organisation Instagram accounts were coded and analysed. Results highlight that the most common image elements used included natural backgrounds, mammals and birds, and no human presence. In addition, it was found that the taxon of the animal featured in a post and the presence of humans did not impact engagement levels. Our findings highlight the potential for Instagram posts to feature and promote a wide range of currently underrepresented species, and for conservation organisations to be able to confidently share and post images that promote positive perceptions of both the animal and the conservation organisation.
Partisan discrimination without explicit partisan cues

Much research has demonstrated that Democrats and Republicans use information about party affiliation to discriminate against one another. However, we know little about how people gain the necessary information about other people’s partisanship to engage in discriminatory behavior. We explore whether people perceive partisanship when shown only images of faces, and whether they then use these perceptions to engage in partisan discrimination. We find that they do. Using two studies we show that the partisan perceptions people derive from seeing images of faces influence discrimination of job applicants, and propensities to engage is a wide range of social interactions. People appear to be making judgements about partisanship using only facial appearance, and are willing act on that perception. The implication of this finding is that partisan discrimination is likely widespread, and does not require the explicit communication of partisan affiliations.