Miracle-dz/UniFAR-FTUs huggingface dataset:
Some Further Results on the Exact Small Sample Properties of the Instrumental Variable Estimator

New results on the exact small sample distribution of the instrumental variable estimator are presented by studying an important special case. The exact closed forms for the probability density and cumulative distribution functions are given. There are a number of surprising findings. The small sample distribution is bimodal. with a point of zero probability mass. As the asymptotic variance grows large, the true distribution becomes concentrated around this point of zero mass. The central tendency of the estimator may be closer to the biased least squares estimator than it is to the true parameter value. The first and second moments of the IV estimator are both infinite. In the case in which least squares is biased upwards, and most of the mass of the IV estimator lies to the right of the true parameter, the mean of the IV estimator is infinitely negative. The difference between the true distribution and the normal asymptotic approximation depends on the ratio of the asymptotic variance to a parameter related to the correlation between the regressor and the regression, error. In particular, when the instrument is poorly correlated with the regressor, the asymptotic approximation to the distribution of the instrumental variable estimator will not be very accurate.
Geochemistry and Sources Apportionment of Major Ions and Dissolved Heavy Metals in a Small Watershed on the Tibetan Plateau

Due to environmental sensibility and fragility, the water chemistry revolution and heavy metals accumulation influenced by natural and anthropogenic processes in the rivers on the Tibetan Plateau have recently become a global concern. However, targeted studies in small watersheds on the Tibetan Plateau are relatively limited. A study of surface waters in Duilong Qu (DLQ), a small watershed located on the Tibetan Plateau, have been conducted to assess the impact of natural and anthropogenic activities on the water environment of the DLQ by analyzing the major ions and heavy metals (Cd, Cr, Mn, Fe, Ni, Cu, Zn, Pb, and As) in the river waters. The results of the analysis of major ions showed that SO42− and HCO3− were the dominant anions and Ca2+ was the dominant cation, indicating that the water chemistry of the river waters was mainly of the HCO3-Ca type. The results of Piper diagram and Gibbs diagram analysis indicate that the water solute is mainly controlled by the weathering of carbonate rocks, followed by the influence of geothermal water confluence. Compared to the world river average, the concentrations of Cr, Pb, and As in the studied rivers were relatively high. The heavy metal concentrations satisfy the standards of WHO and GB (Chinese national standard) guidelines. The PCA-APCS-MLR model has been employed and evidenced as a reliable tool to identify the sources of the heavy metals in this study. The results revealed that the heavy metals in the DLQ are caused by natural sources, geothermal water, and mining operations. The primary sources of As (93.63%), Cr (93.07%), Mn (73.53%), Fe (59.54%), and Pb (58.28%) in the DLQ were geothermal water, while Zn (91.41%), Mn (20.67%), Fe (40.46%), and Pb (26.15%) originated mainly from natural sources. Additionally, Cu (91.41%) was primarily influenced by mining operations, and Ni originated from mining (53.61%) and geothermal water sources (46.39%), while Cd (97.88%) originated from unknown sources. In the high-flow season periods from 1992 to 2017, the As concentrations in the DLQ decreased significantly, which might result from increasing precipitation and runoff. Overall, the results of this study suggest that both natural and anthropogenic activities have jointly affected the solutes in small rivers on the Tibetan Plateau, and heavy metal pollution should be emphasized in the future.
Role of Liver CD38 in the Regulation of Metabolic Pathways during Cold-Induced Thermogenesis in Mice

Boosting NAD+ levels are considered a promising means to promote healthy aging and ameliorate dysfunctional metabolism. The expression of CD38, the major NAD+-consuming enzyme, is downregulated during thermogenesis in both brown and white adipose tissues (BAT and WAT). Moreover, BAT activation and WAT “browning” were enhanced in Cd38−/− mice. In this study, the role of CD38 in the liver during thermogenesis was investigated, with the liver being the central organ controlling systemic energy metabolism. Wild-type mice and Cd38−/− mice were exposed to cold temperatures, and levels of metabolites and enzymes were measured in the livers and plasma. During cold exposure, CD38 expression was downregulated in the liver, as in BAT and WAT, with a concomitant increase in NAD(H) and a marked decrease in NADPH levels. Glucose-6-phosphate dehydrogenase and the malic enzyme, along with enzymes in the glycolytic pathway, were downregulated, which is in line with glucose-6-P being re-directed towards glucose release. In Cd38−/− mice, the cross-regulation between glycolysis and glucose release was lost, although this did not impair the glucose release from glycogen. Glycerol levels were decreased in the liver from Cd38−/− animals upon cold exposure, suggesting that glyceroneogenesis, as gluconeogenesis, was not properly activated in the absence of CD38. SIRT3 activity, regulating mitochondrial metabolism, was enhanced by cold exposure, whereas its activity was already high at a warm temperature in Cd38−/− mice and was not further increased by the cold. Notably, FGF21 and bile acid release was enhanced in the liver of Cd38−/− mice, which might contribute to enhanced BAT activation in Cd38−/− mice. These results demonstrate that CD38 inhibition can be suggested as a strategy to boost NAD+ and would not negatively affect hepatic functions during thermogenesis.
Validation of Wearable Device Consisting of a Smart Shirt with Built-In Bioelectrodes and a Wireless Transmitter for Heart Rate Monitoring in Light to Moderate Physical Work

Real-time monitoring of heart rate is useful for monitoring workers. Wearable heart rate monitors worn on the upper body are less susceptible to artefacts caused by arm and wrist movements than popular wristband-type sensors using the photoplethysmography method. Therefore, they are considered suitable for stable and accurate measurement for various movements. In this study, we conducted an experiment to verify the accuracy of our developed and commercially available wearable heart rate monitor consisting of a smart shirt with bioelectrodes and a transmitter, assuming a real-world work environment with physical loads. An exercise protocol was designed to light to moderate intensity according to international standards because no standard exercise protocol for the validation simulating these works has been reported. This protocol includes worker-specific movements such as applying external vibration and lifting and lowering loads. In the experiment, we simultaneously measured the instantaneous heart rate with the above wearable device and a Holter monitor as a reference to evaluate mean absolute percentage error (MAPE). The MAPE was 0.92% or less for all exercise protocols conducted. This value indicates that the accuracy of the wearable device is high enough for use in real-world cases of physical load in light to moderate intensity tasks such as those in our experimental protocol. In addition, the experimental protocol and measurement data devised in this study can be used as a benchmark for other wearable heart rate monitors for use for similar purposes.
Correlates of Cancer-Related Fatigue among Colorectal Cancer Patients Undergoing Postoperative Adjuvant Therapy Based on the Theory of Unpleasant Symptoms

Background: Cancer-related fatigue (CRF) is a common and burdensome symptom in cancer patients that is influenced by multiple factors. Identifying factors associated with CRF may help in developing tailored interventions for fatigue management. This study aimed to examine the correlates of CRF among colorectal cancer patients undergoing postoperative adjuvant therapy based on the theory of unpleasant symptoms. Methods: A cross-sectional study was implemented, and finally, a sample of 363 participants from one tertiary general hospital and one tertiary cancer hospital was purposively recruited. Data were collected using the general information questionnaire, cancer fatigue scale, the distress disclosure index, Herth hope index, and perceived social support scale. Univariate analysis and multiple linear regression analysis were performed to determine the correlates of CRF. Results: The mean score of CRF among colorectal cancer patients was 21.61 (SD = 6.16, 95% CI 20.98–22.25), and the fatigue degree rating was “moderate”. The multiple linear regression model revealed that 49.1% of the variance in CRF was explained by hope, sleep disorder, internal family support, self-disclosure, pain, and time since operation. Conclusions: Our study identified several significant, modifiable factors (self-disclosure, hope, internal family support, pain, and sleep disorder) associated with CRF. Understanding these correlates and developing targeted psychosocial interventions may be associated with the improvement of CRF in patients with colorectal cancer.
Edible Flowers Used in Some Countries of the Mediterranean Basin: An Ethnobotanical Overview

Edible flowers are becoming an essential component of people’s nutrition in the Mediterranean basin. In the last decades, many researchers also have focused their attention on the nutritional composition of the edible flowers, as well as their antioxidant and antimicrobial properties, including studies on their safety issues. Despite the growing interest in the use of flowers in human nutrition, the ethnobotanical literature is lacking coverage of some important issues, particularly those which concern the use of flowers in the folk tradition. Only recently, a review regarding the contribution of 32 edible flowers to the Mediterranean diet was published. The aim of the present review is to document the plant lore regarding the wild and cultivated edible flowers consumed in the Mediterranean basin. Based on the 112 studies reviewed, we documented 251 taxa as being used in the Mediterranean basin as edible flowers. The plant species belong to 45 families and 141 genera. Asteraceae (54 taxa) is the most frequently cited family. Sambucus nigra L. is the most cited species. This study can be the basis for future research on the supposed bioactivity and toxicity of wild and cultivated flowers.
Drug Repositioning in Response to COVID-19 and other Challenging Diseases

Coronavirus disease is a highly contagious infection that is majorly associated with upper respiratory tract illnesses. The World Health Organization (WHO) label the novel coronavirus disease COVID-19 after an epidemic of the disease in Wuhan, Hubei province (China). Over 90 clinical trials, including drug repositioning, have been initiated to get COVID-19 treatment/management. Antibiotic resistance, drug tolerance, mutation, and adverse drug effects possess a lot of setbacks during therapy, especially with emerging infectious diseases. This necessitates the need for research into getting newer drugs or repositioning the available ones to meet up with the treatment of both infectious and non-infectious diseases affecting humanity. Drug repositioning is a stepwise process that aids in discovering new indications and therapeutic targets of drugs and it usually takes 3-12 years on average to be completed whereas, in drug discovery, an average of 10-17 years is needed for the whole process. This is because, in repositioning, the research process goes straight to preclinical and clinical trials since both the toxicological and pharmacological profiles of the drug to be repositioned are known, thus reducing time, risk, and costs. Based on 2009 statistics, 30% of all drugs sold in that year are products of repositioning while only one out of one million potential drug candidates have the possibility of entry into clinical studies with a tendency of significant failures. Hence the need to discover additional uses for already established drugs, especially with the emergence of COVID-19. Drug repositioning is therefore considered an alternative way to new drug development as it entails the discovery of newer therapeutic uses of established drugs. Copyright © 2022 Hyellavala Joseph Fomnya, Saidu Ibrahim Ngulde, Sarah Malgwi Gana, Garleya Bilbonga, Kazabu Ahmed Amshi, Chahari Alfred Midala and Kabiru Alhaji Garba.
Attention and Emotion Recovery Effects of Urban Parks during COVID-19—Psychological Symptoms as Moderators

Previous research that compared the restorative effects of natural settings with poor-quality urban settings may have exaggerated the restorative benefits of greenspace. Few studies have been conducted to examine the restorative benefits of green streets and other types of park landscapes on attention and emotion. In addition, it is not clear how negative psychological symptoms (e.g., stress, depression) affect natural’s restorative benefits, especially as the current COVID-19 pandemic has added to people’s psychological burden. In this study, 125 participants were randomly assigned to view one of five videos (green street, lawn, plaza, forest, waterside) for a break after completing an emotion and attention fatigue induction task. Attention function and emotion were measured using the backward digit span test and the Self-Assessment Manikin scale. Stress and depressive symptoms experienced over the last month were measured using the Perceived Stress Scale(PSS-10) and the Patient Health Questionnaire(PHQ-9). Our results indicate that the four park settings showed significant attention function recovery and valence improvement compared to the green streets, while subjects’ arousal changed only over time. Hardscapes (plazas) could provide the same attentional and emotional restorative benefits as natural landscapes (forests, watersides, lawns). In addition, we also found that the mood-improving benefits of natural environments may decrease with increasing depressive symptoms, although chronic stress symptoms did not show the same trend.
Comparison of Different Extraction Techniques and Conditions for Optimizing an HPLC-DAD Method for the Routine Determination of the Content of Chlorogenic Acids in Green Coffee Beans

Chlorogenic acids (CGAs) are the main phenolic compounds found in green coffee beans. They are receiving more attention recently due to the proven health and nutrition benefits they offer, in addition to their role as markers for coffee quality. A relatively large number of studies are reported in the literature that are based on the analysis of these compounds. However, very limited research is dedicated to the evaluation of the performance of the analytical methods used, particularly the extraction procedures. Therefore, this work was dedicated to the comparison of different extraction techniques and conditions in order to evaluate their influence on the measured content of the three main CGAs in green coffee beans, namely, chlorogenic acid (5-CQA), neochlorogenic acid (3-CQA) and cryptochlorogenic acid (4-CQA). Five simple extraction techniques with affordable equipment were compared in order to develop a routine method suitable for most analytical and food analysis laboratories. The compared extraction techniques provided relatively similar extraction efficiency for the three compounds. However, due to the merits of ultrasonic-assisted extraction as a fast, effective, green, and economical technique, this was selected for comparing the extraction variables and developing an optimized routine method. The extraction solvent, temperature, time, solid-to-solvent ratio, and grinding treatments were the variables that were investigated. The extraction solvent and the solid-to-solvent ratio were found to be the most influencing variables that may improve the extraction efficiency to up to 50%. Based on this thorough investigation, an optimized method for the routine determination of the content of chlorogenic acids in green coffee beans was developed. The developed method is simple, fast, and efficient in the extraction of the three main CGAs.
Formulation, Characterization, Anti-Inflammatory and Cytotoxicity Study of Sesamol-Laden Nanosponges

Sesamol (SES) possesses remarkable chemotherapeutic activity, owing to its anti-inflammatory and antioxidant potential. However, the activity of SES is mainly hampered by its poor physicochemical properties and stability issues. Hence, to improve the efficacy of this natural anti-inflammatory and cytotoxic agent, it was loaded into β-cyclodextrin nanosponges (NS) prepared using different molar ratios of polymer and crosslinker (diphenyl carbonate). The particle size of SES-laden NS (SES-NS) was shown to be in the nano range (200 to 500 nm), with a low polydispersity index, an adequate charge (−17 to −26 mV), and a high payload. Field emission scanning electron microscopy, thermogravimetric analysis, and Fourier transform infrared spectroscopy were used to characterize the bioactive-loaded selected batch (SES-NS6). This batch of nanoformulations showed improved solubilization efficacy (701.88 µg/mL) in comparison to bare SES (244.36 µg/mL), polymer (β-CD) (261.43 µg/mL), and other fabricated batches. The drug release data displayed the controlled release behavior of SES from NS. The findings of the egg albumin denaturation assay revealed the enhanced anti-inflammatory potential of SES-NS as compared to bare SES. Further, the cytotoxicity assay showed that SES-NS was more effective against B16F12 melanoma cell lines than the bioactive alone. The findings of this assay demonstrated a reduction in the IC50 values of SES-NS (67.38 μg/mL) in comparison to SES (106 μg/mL). The present investigation demonstrated the in vitro controlled release pattern and the enhanced anti-inflammatory and cytotoxic activity of SES-NS, suggesting its potential as a promising drug delivery carrier for topical delivery.
Blockade of c-Met-Mediated Signaling Pathways by E7050 Suppresses Growth and Promotes Apoptosis in Multidrug-Resistant Human Uterine Sarcoma Cells

E7050 is a potent inhibitor of c-Met receptor tyrosine kinase and has potential for cancer therapy. However, the underlying molecular mechanism involved in the anti-cancer property of E7050 has not been fully elucidated. The main objective of this study was to investigate the anti-tumor activity of E7050 in multidrug-resistant human uterine sarcoma MES-SA/Dx5 cells in vitro and in vivo, and to define its mechanisms. Our results revealed that E7050 reduced cell viability of MES-SA/Dx5 cells, which was associated with the induction of apoptosis and S phase cell cycle arrest. Additionally, E7050 treatment significantly upregulated the expression of Bax, cleaved PARP, cleaved caspase-3, p21, p53 and cyclin D1, while it downregulated the expression of survivin and cyclin A. On the other hand, the mechanistic study demonstrated that E7050 inhibited the phosphorylation of c-Met, Src, Akt and p38 in HGF-stimulated MES-SA/Dx5 cells. Further in vivo experiments showed that treatment of athymic nude mice carrying MES-SA/Dx5 xenograft tumors with E7050 remarkably suppressed tumor growth. E7050 treatment also decreased the expression of Ki-67 and p-Met, and increased the expression of cleaved caspase-3 in MES-SA/Dx5 tumor sections. Therefore, E7050 is a promising drug that can be developed for the treatment of multidrug-resistant uterine sarcoma.
Earnings quality and the cost of debt: A case study of Vietnam

Abstract This paper examines the impact of earnings quality (EQ) on the Vietnam companies’ cost of debt (COD). We use data from companies listed on the Vietnam stock market from 2010 to 2019. In this paper, we develop a model to investigate the influence of audit quality and foreign ownership on COD. We find that EQ had a negative relationship with COD. However, when firm is in financial distressed, EQ has a positive relationship with COD. As an intermediate variable, EQ also has a negative relationship with COD.
Occupied and unoccupied surface states on the Si(111)√3×√3:B surface

The Si(111)√3×√3:BR30 o surface has been studied with k-resolved inverse photoemission and angle-resolved photoemission. In the unoccupied region of the band structure, one strongly dispersing surface state is observed and in the occupied region, three surface states are observed. The unoccupied surface state is identified as an empty dangling-bond state and two of the occupied surface states are identified as backbond states of the adatom
Topological model of flow regimes in the plane of symmetry of a surface-mounted obstacle

Flow visualization between Reynolds numbers of 2000 and 6500 in the end-wall region of an obstacle mounted on a flat plate revealed presence of a multiple vortex system. Three Reynolds-number dependent regimes were identified. With increasing Reynolds number the vortex system transitioned from a static system to a to-and-fro oscillating system and finally to a shedding-splitting system. These observations have been used to infer flow topologies in the plane of symmetry of the juncture from start-up through all three regimes.
Changes in Rainfall and Temperature and Its Impact on Crop Production in Moyamba District, Southern Sierra Leone

Rainfall and temperature are the important variables that are often used to trace climate variability and change. A Perception study and analysis of climatic data were conducted to assess the changes in rainfall and temperature and their impact on crop production in Moyamba district, Sierra Leone. For the perception study, 400 farmers were randomly selected from Farmer-Based Organizations (FBOs) in 4 chiefdoms and 30 Agricultural Extension Workers (AWEs) in the Moyamba district were purposely selected as respondents. Descriptive statistics and Kendall’s test of concordance was used to analyze the data collected from the farmers and AEWs. Data for the analysis of variability and trends of rainfall and temperature from 1991 to 2020 were obtained from the Sierra Leone Meteorological Agency and Njala University and grouped into monthly, seasonal and annual time series. Regression ana-lyses were used to determine the statistical values and trend lines for the seasonal and annual time series data. The Mann-Kendall test and Sen’s Slope Estimator were used to analyze the significance and magnitude of the trends respectively. The results of both studies show evidence of climate change in the Moyamba district. A substantial number of farmers and AEWs perceived a decrease in the annual rainfall amount, length of the rainy season, a late start and end of the rainy season, an increase in the temperature during the day and night, and a shortened harmattan period over the last 30 years. Analysis of the meteorological data shows evidence of variability in the seasonal