Miracle-dz/UniFAR-FTUs huggingface dataset:
Extraovarian juvenile granulosa cell tumor in a prepubertal child: novel location of a rare tumor

Abstract Juvenile granulosa cell tumor (JGCT) is the most common type of sex cord stromal tumor arising from gonadal structures of children and young adults. We present a 3.5-year-old girl with JGCT located in retroperitoneum without ovarian involvement. Extragonadal occurrences of other sex cord stromal tumors have been rarely reported, but this is the first case of JGCT in an extragonadal location. We speculate the possible underlying mechanism of sex cord stromal tumor formation in extragonadal locations. Furthermore, clinical presentation, differential diagnosis and management of this tumor in childhood are discussed.
The commissura anterior compensates asymmetries of visual representation in pigeons

ABSTRACT This study was undertaken to understand what is transferred between hemispheres through the commissura anterior during a colour discrimination task in pigeons. We transiently blocked neuronal activity of the arcopallium of one hemisphere to interrupt interhemispheric communication. Before and during this intervention, we recorded from arcopallial neurons of the non-anaesthetized side while the animals discriminated stimuli ipsilateral to the recorded neurons. Due to the complete crossover of optic nerves in birds, we assumed that these neurons were at least in part requiring information from the other hemisphere to properly run the task. While lidocaine injections in both hemispheres caused some performance reductions, deficits of right arcopallial neurons were much larger when blocking interhemispheric transfer. Our results make it likely that visual information is exchanged through the commissura anterior in an asymmetrical manner with the left hemisphere providing the other side more information about the right visual half-field than vice versa.
Determinants of Frequency and Contents of Postnatal Care Among Women in Ezha District, Southern Ethiopia, 2020: Based on WHO Recommendation

Background Postnatal care is a constellation of preventive care, practices, and assessments intended to detect and treat complications for both the mother and the newborn in the first six following birth. Monitoring of the content and frequency of the PNC is required to make the service provision more successful. However, several studies centered on the general PNC visits, and pieces of evidence were limited at the country level on the core content of the PNC, including the current study area. Therefore, this study aimed to identify determinants of the frequency and content of PNC visits among women who gave birth in the last 12 months in Ezha district, Southern Ethiopia. Methods and Materials A community-based cross-sectional survey was conducted in the Ezha district to collect data from 568 respondents by using pre-tested, interviewer-administered questionnaires. Data were entered into EpiData3.1 and exported to SPSS version 23 for analysis. To determine the wealth status of the respondents, the Principal Component Analysis was undertaken. To evaluate the determinants of frequency and the content of PNC, both binary logistic regression and generalized linear regression with Poisson type were applied respectively. Results Nearly a quarter (23.9%) of respondents received three or more postnatal visits, and only 81 (14.6%) respondents received all the PNC service contents suggested by WHO. Identified predictors of the core content of PNC were, frequencies of ANC (AOR: 1.25, 95% CI: 1.15–1.35), enrollment in community-based health insurance scheme (AOR: 0.69 (95% CI: 0.64–0.75), and PNC frequency (AOR: 0.64, (95% CI (0.57–0.73). Conclusion A low level of WHO-recommended frequency and content of the PNC were identified in the study area. To achieve better utilization, strengthening efforts to improve adequate ANC uptake, enrollment in the CBHI scheme, and working on a model household creation were, therefore, should be crucial measures.
Influence of digoxin on mortality in patients with atrial fibrillation: Overview of systematic reviews

Once a routine part of atrial fibrillation (AF) management, digoxin use has declined. Likely hastening this decline are findings from several studies and systematic reviews identifying a potential association between digoxin use and all‐cause mortality in AF populations. However, inconsistency exists within some of these studies potentially leading to confusion among clinicians. To critically evaluate the current literature to contextualize the associations between digoxin and mortality risk in patients with AF by performing an overview of systematic reviews. We searched MEDLINE, Cochrane Central Database of Systematic Reviews, and SCOPUS from their earliest date through October 12, 2020, to identify systematic reviews (SRs) that included studies enrolling patients with AF or atrial flutter and evaluated the association between digoxin use and all‐cause mortality. We used the AMSTAR 2 tool to assess the risk of bias for each included SR. Results from reviews are qualitatively synthesized. Our search identified 10 SRs that met our inclusion criteria. Of the 41 unique AF studies included in these SRs, 41% were cohort studies, 29% were post hoc analyses of randomized controlled trials (RCTs), 15% were RCTs, and 15% were registry studies. Based on our AMSTAR 2 assessment, the overall confidence in the results of the 10 reviews was rated as “moderate” in three SRs, “low” in three SRs, and “critically low” in the rest. Except for one review, each included SR shows that digoxin use in AF is associated with a 15 to 38% higher risk of all‐cause mortality. This association may be greater when AF‐only populations are considered compared with a mix of AF and heart failure populations. Serum digoxin concentration (SDC) data were infrequently considered, but available data suggested a greater association between increasing SDC and all‐cause mortality. This overview of reviews found general consistency regarding the association between digoxin use and higher all‐cause mortality in AF populations. However, heterogeneity exists among and between SRs and an unmet need exists for additional study in a RCT setting with close monitoring and reporting of SDC to better inform clinical practice.
Experiences of stakeholder collaboration when promoting participation in physical activity among adolescents with autism spectrum disorder

Abstract Purpose Various stakeholders contribute to the development of healthy physical activity habits in adolescents with autism spectrum disorder (ASD). Parents and stakeholders seek collaborative actions but little is still known about such efforts. The purpose of this study was thus to explore how professionals from different services experience stakeholder collaboration when promoting participation in physical activity for these adolescents. Method Five focus group discussions were held with 17 professionals from education, health care, community, and sports organizations, engaged in the promotion of physical activity in adolescents with ASD. The data were analyzed with qualitative content analysis. Results The discussions revolved around a central theme: Collaboration is needed to promote physical literacy among adolescents with ASD. The professionals though experienced that this collaboration was hampered by the low priority given to physical activity issues within different organizations, by limited resources, lack of knowledge, and unclear roles. Conclusions Notwithstanding the professionals’ different roles, all agreed that physical activity issues need to be prioritized and that each stakeholder needs to acknowledge the shared responsibility of collaboration. However, more clear routines for collaboration that include joined efforts but also highlight the organization-specific responsibilities might enhance the collaborative efforts. IMPLICATIONS FOR REHABILITATION In-depth understanding of both the adolescents’ needs and the environments in which physical activity is promoted is required if participation in physical activity among adolescents with ASD is to be enhanced. Families and professionals within different organizations need to be supported to collaborate when mapping and meeting the adolescents’ physical activity needs. Issues regarding developing physical activity habits need to be prioritized. Professionals, such as education, health, and community professionals who are important for the promotion of healthy physical activity habits need to be included in multi-stakeholder meetings.
Dorsal anterior cingulate cortex intrinsic functional connectivity linked to electrocortical measures of error-monitoring

The error-related negativity (ERN) is a response-locked event-related potential, occurring approximately 50 ms following an erroneous response at frontocentral electrode sites. Source localization and functional magnetic resonance imaging (fMRI) research indicate that the ERN is likely generated by activity in the dorsal anterior cingulate cortex (dACC). The dACC is thought to be a part of a broader network of brain regions that collectively comprise an error-monitoring network. However, little is known about how intrinsic connectivity within the dACC-based error-monitoring network contributes to variability in ERN amplitude. The purpose of this study was to assess the relationship between dACC functional connectivity and ERN amplitude. In a sample of 53 highly trait-anxious individuals, the ERN was elicited in a flanker task and functional connectivity was assessed in a 10-minute resting-state fMRI scan. Results suggest that the strength of dACC seeded functional connectivity with the supplementary motor area is correlated with the ΔERN (i.e., incorrect – correct responses) amplitude such that greater ΔERN amplitude was accompanied by greater functional coupling between these regions. In addition to the dACC, exploratory analyses found that functional connectivity in the caudate, cerebellum, and a number of regions in the error-monitoring network were linked to variability in ΔERN amplitude. In sum, ERN amplitude appears to be related to the strength of functional connectivity between error-monitoring and motor control regions of the brain.
Processing of facial expressions of same-race and other-race faces: distinct and shared neural underpinnings

Abstract People understand others’ emotions quickly from their facial expressions. However, facial expressions of ingroup and outgroup members may signal different social information and thus be mediated by distinct neural activities. We investigated whether there are distinct neuronal responses to fearful and happy expressions of same-race (SR) and other-race (OR) faces. We recorded electroencephalogram from Chinese adults when viewing an adaptor face (with fearful/neutral expressions in Experiment 1 but happy/neutral expressions in Experiment 2) and a target face (with fearful expressions in Experiment 1 but happy expressions in Experiment 2) presented in rapid succession. We found that both fearful and happy (vs neutral) adaptor faces increased the amplitude of a frontocentral positivity (P2). However, a fearful but not happy (vs neutral) adaptor face decreased the P2 amplitudes to target faces, and this repetition suppression (RS) effect occurred when adaptor and target faces were of the same race but not when of different races. RS was observed on two late parietal/central positive activities to fearful/happy target faces, which, however, occurred regardless of whether adaptor and target faces were of the same or different races. Our findings suggest that early affective processing of fearful expressions may engage distinct neural activities for SR and OR faces.
Classification of multiple sclerosis based on patterns of CNS regional atrophy covariance

There is evidence that multiple sclerosis (MS) pathology leads to distinct patterns of volume loss over time (VLOT) in different central nervous system (CNS) structures. We aimed to use such patterns to identify patient subgroups. MS patients of all classical disease phenotypes underwent annual clinical, blood, and MRI examinations over 6 years. Spinal, striatal, pallidal, thalamic, cortical, white matter, and T2‐weighted lesion volumes as well as serum neurofilament light chain (sNfL) were quantified. CNS VLOT patterns were identified using principal component analysis and patients were classified using hierarchical cluster analysis. 225 MS patients were classified into four distinct Groups A, B, C, and D including 14, 59, 141, and 11 patients, respectively). These groups did not differ in baseline demographics, disease duration, disease phenotype distribution, and lesion‐load expansion. Interestingly, Group A showed pronounced spinothalamic VLOT, Group B marked pallidal VLOT, Group C small between‐structure VLOT differences, and Group D myelocortical volume increase and pronounced white matter VLOT. Neurologic deficits were more severe and progressed faster in Group A that also had higher mean sNfL levels than all other groups. Group B experienced more frequent relapses than Group C. In conclusion, there are distinct patterns of VLOT across the CNS in MS patients, which do not overlap with clinical MS subtypes and are independent of disease duration and lesion‐load but are partially associated to sNfL levels, relapse rates, and clinical worsening. Our findings support the need for a more biologic classification of MS subtypes including volumetric and body‐fluid markers.
Effect of polymer coated urea, irrigation, and drainage on nitrogen utilization and yield of corn in a claypan soil.

Slow-release N fertilizers, such as polymer-coated urea (PCU), may increase crop N use and reduce NO 3 -N leaching. Research was conducted to evaluate NO 3 ―N concentrations of soil water samples in noncoated urea (NCU) and PCU treated plots under different water management systems, and to determine differences in crop yields and N utilization among water and urea management systems. Water management treatments included: no irrigation or drainage (NIN), no irrigation and drainage with subsurface drain tiles 6.1 m apart (NID), subirrigation and drainage with tiles 6.1 m apart (SUB), and overhead irrigation with no drainage (OND), which were split into preplant-applied NCU or PCU at 0, 140, and 280 kg N ha ―1 . Water samples from suction lysimeters at a 45-cm depth in soil treated with PCU had 51 to 63% lower NO 3 ―N concentration than NCU 59 d after application (DAA), while NCU had 85 to 92% lower N concentration than PCU 153 DAA. In 2005, N uptake was ranked OND > SUB ≥ NID = NIN for PCU and NCU treatments. Grain yield for water management systems was ranked NID = SUB ≥ OND ≥ NIN in 2004 and OND > SUB > NID ≥ NIN in 2005. No grain or silage yield differences between PCU and NCU treatments when applied at similar rates were observed in either year. This study showed no increase in N uptake by the crop with PCU compared with NCU; however, PCU reduced subsoil NO 3 ―N concentration early in the season, which may reduce NO 3 ―N leaching.
Time course of changes in V̇O2peak and O2 extraction during ramp cycle exercise following HIIT vs moderate-intensity continuous training in type 2 diabetes.

In the present study we assessed the time course of adaptations in peak oxygen uptake (V̇O2peak) and muscle fractional oxygen (O2) extraction (using near-infrared spectroscopy) following 12 weeks of low-volume high-intensity interval training (HIIT) vs. moderate-intensity continuous endurance training (MICT) in adults with uncomplicated type 2 diabetes (T2D). Participants with T2D were randomly assigned to MICT (n = 12, 50 min of moderate-intensity cycling), HIIT (n = 9, 10 x 1 min at ~90% maximal heart rate) or to a non-exercising control group (n = 9). Exercising groups trained 3 times per week and measurements were taken every 3 weeks. The rate of muscle deoxygenation (i.e. deoxygenated haemoglobin and myoglobin concentration, Δ[HHb+Mb]) profiles of the vastus lateralis muscle were normalised to 100% of the response, plotted against % power output (PO) and fitted with a double linear regression model. V̇O2peak increased (P<0.05) by week 3 of MICT (+17%) and HIIT (+8%), with no further significant changes thereafter. Total increases in V̇O2peak posttraining (P<0.05) were 27% and 14% respectively. The %∆[HHb+Mb] vs %PO slope of the first linear segment (slope1) was reduced (P<0.05) beyond 3 weeks of HIIT and MICT with no further significant changes thereafter. No changes in V̇O2peak or slope1 were observed in the control group. Low-volume HIIT and MICT induced improvements in V̇O2peak following a similar time course and these improvements were likely, at least in part, due to an improved microvascular O2 delivery.
O-Ring Attachments on One-Piece Mini Dental Implants: In-Vitro Analysis of Retention Force Reproducibility Using Different Pristine Matrix-O-Ring Combinations.

PURPOSE To analyze the influence of pristine matrix and O-ring dimensions on retention force and reproducibility in single one-piece mini dental implants (MDIs) with ball patrices under in vitro conditions. MATERIALS AND METHODS Three different matrix and O-ring combinations (MH1-MH3) were evaluated (n = 50 per group) on 1.8-mm-diameter implants. The matrices were manually mounted on the implants and were subsequently removed in a vertical linear manner using a metal pin with two strain gauges, recording the maximum force during disconnection. After five disconnections, the O-rings were exchanged, and the mean retention force was calculated, resulting in 50 values for each matrix and O-ring combination. Mean retention forces, SDs, and 95% CI were calculated. Analysis of variance was used to test the global differences, and post hoc pairwise comparisons were subsequently applied. The level of significance was set to P < . 05. RESULTS ANOVA (global P < .0001) and pairwise comparisons (all P < .0001) demonstrated statistically significant differences among the three different matrix and O-ring combinations, with mean values of 5.18 N (MH 1), 6.73 (MH 2), and 9.08 (MH 3). Within each combination, retention force variations of > 1 N could not be demonstrated; ie, by exchanging O-rings, a similar retention force can be reestablished. CONCLUSION Matrix and O-ring dimensions have a significant influence on retention forces in one-piece MDIs. Pristine O-rings demonstrated highly reproducible initial retention forces in all matrices.
Distribution of IgG subclass anti-nuclear antibodies (ANAs) in systemic lupus erythematosus

Objectives Our study purpose was to detect the distribution of anti-nuclear antibody (ANA) IgG subclasses in patients with systemic lupus erythematosus (SLE) and to evaluate their influence on the inflammatory process in SLE. Methods We determined the serum levels of ANA IgG subclasses from 70 SLE patients, 25 patients with other autoimmune diseases (OAD), and 25 healthy controls using ELISA. The serum level of total ANA IgG and the avidity of ANA IgG, dsDNA IgG, and dsDNA IgG subclasses were analysed by ELISA. Results The results indicated that levels of four ANA IgG subclasses (IgG1, IgG2, IgG3 and IgG4) and total IgG were significantly higher in SLE patients than in OAD patients and healthy controls (p < 0.001). Moreover, the level of each ANA IgG subclass and the prevalence of high-avidity IgG ANAs (HA IgG ANAs) were significantly higher in the active cases than in the inactive cases of SLE and LN. Furthermore, level of ANA IgG subclasses decreased as level of dsDNA IgG subclasses decreased in 30 patients with SLE. In comparison, ANA IgG3 was significantly effective in high-dose prednisone combined with hydroxychloroquine (p = 0.025). Additionally, it revealed that level of dsDNA IgG had a significant influence on four ANA IgG subclasses, especially on ANA IgG3 (β coefficient = 0.649, p < 0.001). Level of ANA IgG3 was also positively related to the serum level of dsDNA IgG (r = 0.729, p < 0.001) and RAI of HA IgG ANAs (r = 0.504, p < 0.001). However, the level of ANA IgG4 was positively related to the serum level of albumin (r = 0.572, p < 0.001) and RAI of HA IgG ANAs (r = 0.549, p < 0.001). Moreover, the results revealed that cutaneous and renal involvement were mainly associated with the ANA IgG1 and IgG4 subclasses. Although, arthritic involvement was mainly associated with ANA IgG3. Conclusions First, we demonstrated that the ANA IgG subclasses were diagnostic tools in SLE patients. Furthermore, HA IgG ANAs might affect the distribution of ANA IgG3 and IgG4. Moreover, ANA IgG3 might play a particular role in the activity of SLE disease and therapy. Therefore, an altered ANA IgG subclass distribution might be a risk factor influencing the inflammatory process in SLE.
Cerebral amyloid angiopathy-related inflammation: current status and future implications

Abstract Cerebral amyloid angiopathy-related inflammation (CAA-RI) is a rare but increasingly recognized subtype of CAA. CAA-RI consists of two subtypes: inflammatory cerebral amyloid angiopathy and amyloid β (Aβ)-related angiitis. Acute or subacute onset of cognitive decline or behavioral changes is the most common symptom of CAA-RI. Rapid progressive dementia, headache, seizures, or focal neurological deficits, with patchy or confluent hyperintensity on T2 or fluid-attenuated inversion recovery sequences and evidence of strictly lobar microbleeds or cortical superficial siderosis on susceptibility-weighted imaging imply CAA-RI. The gold standard for diagnosis is autopsy or brain biopsy. However, biopsy is invasive; consequently, most clinically diagnosed cases have been based on clinical and radiological data. Other diagnostic indexes include the apolipoprotein E ε4 allele, Aβ and anti-Aβ antibodies in cerebral spinal fluid and amyloid positron emission tomography. Many diseases with similar clinical manifestations should be carefully ruled out. Immunosuppressive therapy is effective both during initial presentation and in relapses. The use of glucocorticoids and immunosuppressants improves prognosis. This article reviews the pathology and pathogenesis, clinical and imaging manifestations, diagnostic criteria, treatment, and prognosis of CAA-RI, and highlights unsolved problems in the existing research.
An Evaluation of the Genotoxic Effects of Electromagnetic Radiation at 900 MHz, 1800 MHz, and 2100 MHz Frequencies with a SMART Assay in Drosophila melanogaster

ABSTRACT With the development of today’s technology, the electromagnetic radiation spread by mobile phones and base stations is also rapidly increasing, and this causes serious concerns about the environment and human health. The Drosophila model organism is widely used in genetic toxicology studies because its genome is highly similar to the genes identified in human diseases. In this study, the genotoxic effects of radiofrequency electromagnetic radiation were evaluated by the wing Somatic Mutation and Recombination Test (SMART) in Drosophila melanogaster at 900 MHz, 1800 MHz, and 2100 MHz. The SMART method is based on the observation of genetic changes occurring in the trichomes of the Drosophila wings appearing as mutant clones under the microscope. Throughout the study, total clone parameters were evaluated by exposing the Drosophila larvae to electromagnetic fields for two, four, and six hours per day for two days. As a result of the study, it was observed that the number of mutant clones was statistically increased according to the negative control group in all applications except for the six-hour application at 1800 MHz.