Miracle-dz/UniFAR-FTUs huggingface dataset:
HLA-Matched Unrelated Donors for Patients with Sickle Cell Disease: Results of International Donor Searches Biology of Blood and Marrow Transplantation

A B S T R A C T Sickle cell disease (SCD) is the most common inherited hemoglobinopathy. Hematopoietic stem cell transplantation (HCT) is the sole curative therapy for SCD, but few patients will have a matched sibling donor. Patients with SCD are mostly of African origin and thus are less likely to ﬁ nd a matched unrelated donor in international registries. Using HaploStats, we estimated HLA haplotypes for 185 patients with SCD (116 from a Brazilian center and 69 from European Society for Blood and Marrow Transplantation [EBMT] centers) and classi ﬁ ed the ethnic origin of haplotypes. Then we assessed the probability of ﬁ nding an HLA-matched unrelated adult donor (MUD), consid- ering loci A, B, and DRB1 (6/6), in international registries. Most haplotypes were African, but Brazilians showed a greater ethnic admixture than EBMT patients. Nevertheless, the chance of ﬁ nding at least one 6/6 potential allelic donor was 47% for both groups. Most potential allelic donors were from the US National Marrow Donor Program registry and from the Brazilian REDOME donor registry. Although the probability of ﬁ nding a donor is higher than previously reported, strategies are needed to improve ethnic diversity in registries. Moreover, predicting the likelihood of having an MUD might in ﬂ uence SCD management. © 2020 American Society for Transplantation and Cellular Therapy. Published by Elsevier Inc.
Requirement of the NF- κ B Subunit p65/RelA for K-Ras – Induced Lung Tumorigenesis

K-Ras – induced lung cancer is a very common disease, for which there are currently no effective therapies. Because therapy directly targeting the activity of oncogenic Ras has been unsuccessful, a different approach for novel therapy design is to identify critical Ras downstream oncogenic targets. Given that oncogenic Ras proteins activate the transcription factor NF- κ B, and the importance of NF- κ B in oncogenesis, we hypothe-sized that NF- κ B would be an important K-Ras target in lung cancer. To address this hypothesis, we generated a NF- κ B-EGFP reporter mouse model of K-Ras – induced lung cancer and determined that K-Ras activates NF- κ B in lung tumors in situ . Furthermore, a mouse model was generated where activation of oncogenic K-Ras in lung cells was coupled with inactivation of the NF- κ B subunit p65/RelA. In this model, deletion of p65/RelA reduces the number of K-Ras – induced lung tumors both in the presence and in the absence of the tumor suppressor p53. Lung tumors with loss of p65/RelA have higher numbers of apoptotic cells, reduced spread, and lower grade. Using lung cell lines expressing oncogenic K-Ras, we show that NF- κ B is activated in these cells in a K-Ras – dependent manner and that NF- κ B activation by K-Ras requires inhibitor of κ B kinase β (IKK β ) kinase activity. Taken together, these results show the importance of the NF- κ B subunit p65/RelA in K-Ras – induced lung transformation and identify IKK β as a potential therapeutic target for K-Ras – induced lung cancer. Cancer Res; 70(9); 3537 – ©2010 AACR.
Site-specific inductive and inhibitory activities of and orchestrate mammary gland branching

During puberty, mouse mammary epithelial ducts invade the stromal mammary fat pad in a wave of branching morphogenesis to form a complex ductal tree. Using pharmacologic and genetic approaches, we find that mammary gland branching morphogenesis requires transient matrix metalloproteinase (MMP) activity for invasion and branch point selection. MMP-2, but not MMP-9, facilitates terminal end bud invasion by inhibiting epithelial cell apoptosis at the start of puberty. Unexpectedly, MMP-2 also represses precocious lateral branching during mid-puberty. In contrast, MMP-3 induces secondary and tertiary lateral branching of ducts during mid-puberty and early pregnancy. Nevertheless, the mammary gland is able to develop lactational competence in MMP mutant mice. Thus, specific MMPs refine the mammary branching pattern by distinct mechanisms during mammary gland branching morphogenesis.
The Complex Relationship between Childhood Sexual Abuse and Chronic Pain

Background: Generally, the literature shows some relationship between childhood sexual abuse and chronic pain (CP). However, the evidence of this relationship is inconsistent. Purpose: 1. To examine the incidence of childhood sexual abuse in individuals with CP assessed at an Interdisciplinary Chronic Pain Management Program (Michael G. DeGroote Pain Clinic, Hamilton, ON Canada); and 2. To investigate the relationship between childhood sexual abuse and CP by comparing scores on pain-related variables of individuals with a history of sexual abuse to those without. Methods: Data were retrospectively analyzed from a database that includes pain-related measures and demographic information from questionnaires completed at initial psychological assessment at an interdisciplinary chronic pain management program. Data from 363 individuals were available for analysis. Two-way ANOVA (presence or absence of sexual abuse) X (male or female) were conducted to compare the psychometric scores across sexual abuse history and gender. Pain-related measures assessed depressed mood, anxiety, catastrophizing, Kinesiophobia, pain interference, pain intensity, stages of change, and acceptance of pain. Results: The overall incidence of childhood sexual abuse among individuals initially assessed at the Michael G. DeGroote Pain Clinic was 16%; 10.7% of males and 20.1% of females. Those with a history of sexual abuse had higher scores on the Activities Engagement subscale of the Chronic Pain Acceptance Questionnaire (CPAQ) (p = 0.042), and on the Contemplation subscale of the Pain Stages of Change Questionnaire (PSOCQ) (p = 0.037). There were also gender differences in terms of the Pre-contemplation subscale of the PSOCQ (p = 0.054) with males obtaining higher scores. Conclusion: The results suggest a relationship between sexual abuse and adaptation to CP as measured by the PSOCQ and CPAQ. Such findings have not been previously reported.
Knowledge, Attitude and Practice of Mothers on Prevention and Control of Intestinal Parasitic Infection in Sekota Town, Wag-Himra Zone, Ethiopia

Background: Intestinal parasites were a major public health problem in many developing countries. It accounts for 1.5 billion infections with one or more causative agents. The national prevalence of helminthiasis in Ethiopia was 29.8% with considerable variability across the different regions. Young children had a high infection rate and suffered with a substantial worm burden of A. lumbricoides, trichuris trichiura and schistosomes . Parasitic infection has also serious consequences on human health, such as hepatomegaly, bleeding, esophageal varices, delay in physical development. It also decreases the immunity system, level of intelligence, and labor productivity. Therefore, this study was intended to assess mothers’ knowledge, attitude and practice on prevention and control of intestinal parasitic infection among their preschool children in Sekota town, Waghimra zone, Ethiopia Methods: A cross sectional study was carried out on 378 mothers who had under six years but over two years old children. Although, 384 mothers were selected using sample size calculation in the year 2019, the data was collected from 378 mother-child pairs. A face to face interview was performed using pretested and structured questionnaire in the urban villages, Sekota town. The level of maternal knowledge, attitude and practice were presented in percentage, frequence and table. In each step standard operational procedures were followed. Results: The overall level of good knowledge or knoledgable, positive attitude and good practice of mothers towards intestinal parasites prevention and control in considering their preschool children in Sekota town was 45.2%, 55.3% and 51.1% respectively. Seventy-seven 77(20.4%) respondents reported that they knew Ascaris Lumbricoids , 62 (16.4%) participants wash vegetables as a means of intestinal prevention, and 252 (66.7%) of participants stated that their children had at least one stool examination previously. Conclusions: The overall level of optimum knowledge, attitude and practice of mothers on prevention and control of intestinal parasites is low. In particular, the level of optimal knowledge is very low in this study. According to the median parameter, 50% and above of mothers had both positive attitude and good practice. But mothers who were knowledgeable placed below 50%. Therefore, community awareness about parasitic infestation would be created.
Masters Thesis: Controlled dosing of femto-litre volume liquids using hollow cantilevers

A hollow cantilever is used in place of a conventional cantilever to dispense and aspirate liquids in the femto-litre (10−15 L) volume range in an atomic force microscope (AFM) set up. Unlike a conventional AFM cantilever, these cantilevers are made hollow with an on-chip reservoir. Fluid is dispensed through a micro/nanometer scale aperture on the AFM tip. Dispensed (or aspirated) liquid volume is a function of tip contact time, applied pressure in the reservoir, surface energy of the substrate, surface energy of the tip, and surface tension of the liquid. In a conventional AFM, these parameters are usually not taken into consideration, but these factors will influence the dispense (aspirate) process of the hollow cantilever. To control the dispensing and aspiration process of a hollow cantilever, the influence of various factors needs to be analyzed and a dynamic model should be developed. In the present thesis, initial experimental results on the dispensing process and an analytical dynamic model describing the process are reported. The model is based on the relation between the Laplace pressure and volume of the liquid bridge connecting the cantilever tip and the substrate. The model developed could describe the dispensing process with variance accounted for (VAF) larger than 90%. Based on the model, four different controllers are designed : series PID controller, parallel PI controller, combination of feedback linearization and iterative learning control and model reference controller. It was found the combination of feedback linearization and iterative learning control can control the system to dispense desired liquid much fast without any overshoot, and model reference controller can control the system without using system identification. Master of Science Thesis Cao Xi vi Table of
Spatial and temporal variability of CO 2 and CH 4 gas transfer velocities and quantification of the CH 4 microbubble flux in mangrove dominated estuaries LIMNOLOGY and OCEANOGRAPHY

Gas transfer velocities ( k ) of CO 2 and CH 4 were determined from 209 deployments of a newly designed ﬂoating chamber in six mangrove dominated estuaries in Australia and the United States to estimate mangrove system speciﬁc k . k 600 - CO 2 and k 600 - CH 4 ( k normalized to the Schmidt number of 600) varied greatly within and between mangrove creeks, ranging from 0.9 cm h 2 1 to 28.3 cm h 2 1 . The gas transfer velocity correlated well with current velocity at all study sites suggesting current generated turbulence was the main driver controlling k . An empirical relationship that accounts for current velocity and a linearly additive contribution of wind speed and water depth was a good predictor of k 600 -CO 2 ( R 2 5 0.67) and k 600 -CH 4 ( R 2 5 0.57) in the mangrove creeks in Australia. In a side-by-side study, good agreement was found between k determined from this new ﬂoating chamber and a 3 He/SF 6 dual tracer release experiment ( (cid:2) 5% discrepancy). k 600 - CH 4 correlated well with k 600 - CO 2 ( R 2 5 0.81), however, k 600 - CH 4 was on average 1.2 times higher than k 600 - CO 2 , most likely reﬂecting a microbubble ﬂux contribution. The microbubble ﬂux contributed up to 73% of the total CH 4 ﬂux and was
A Proof of Principle of Imposed Dynamo Current Drive: Demonstration of Sufficient Confinement

Abstract The conceptual design of an experiment for demonstrating and developing the efficient sustainment of a spheromak with sufficient confinement is presented. “Sufficient” means that the current drive power can heat the plasma to its stability β limit. Previous transient experiments showing sufficient confinement in the kilo-electron-volt temperature range with no external toroidal field coil, recent results on Helicity Injected Torus with Steady Inductive (HIT-SI) showing sustainment with sufficient confinement, the potential of imposed dynamo current drive (IDCD) of solving other fusion issues, and a very attractive reactor concept justify a proof-of-principle experiment for a high-β spheromak sustained by IDCD. A machine with 1-m minor radius with the required density control, wall loading, and neutral shielding for a 10-s pulse is described. Peak temperatures of 3 keV and toroidal currents of 3.2 MA and 16% wall-normalized plasma β are envisioned.
The View from Above: A Survey of the Public’s Perception of Unmanned Aerial Vehicles and Privacy

ABSTRACT Unmanned Aerial Vehicles (UAVs) are becoming increasingly popular, both for hobbyists and within the commercial, industrial, and military sectors. Approximately one million new UAVs have been registered in the United States, with the majority being recreational UAVs. This growth of UAV activity and their increasingly common public presence engenders a wide variety of opinions, perceptions, and concerns among individuals about UAVs, particularly concerning personal privacy. Drawing from the privacy and emerging technology literature, the purpose of this paper is to identify how individuals’ perceptions of privacy explain their attitudes on the use of UAVs and whether this aligns with what we would expect from an emerging technology. Utilizing Amazon’s Mechanical Turk (MTurk) for survey delivery to 2,108 respondents we conducted a descriptive statistical analysis of response frequency and t-tests of group mean differences. The results suggest that individuals who use UAVs, maintain a familiarity with the capabilities of UAVs, and have a basic understanding of UAV regulations, are somewhat less concerned about the growing presence of UAVs as it relates to privacy than individuals who are generally unfamiliar with UAVs, their capabilities, and UAV regulations. Policy implications of these results are discussed.
Corporate Taxation, Tax Administration and Development

This paper analyzes whether corporate tax policies differ between developed and developing countries. I show that the relation between tax policies and development follows a U-shaped pattern when tax policies are coordinated within the country. The predictions of the model are only partially in line with observed tax policies because developing countries usually have the weakest administrative structures. The model is, however, fully consistent with the observed tax policies under the premise that within developing countries tax policies are not coordinated. Thus, the analysis suggests a so far unmentioned difference between developed and developing countries’ tax policy determination. Finally, I show that an intensified fight against tax havens unambiguously increases tax revenues in developed countries but decreases tax revenues in developing countries whenever policies are chosen in isolation or the fight against tax havens is sufficiently successful despite joint tax policy optimization.
A Model Of Antecedents And Consequences Of Employee Social Conformityin Organization

Objective: Due to the importance of employee social conformity in the organization and its negative consequences in organizational behavior, the study aimed to "present a model of the antecedents and consequences of employee social conformity in organizations" to better understand the constructive factors resulting from social conformity in organizations. Method: The qualitative content analysis has been used in this research,and the antecedents and consequences of social conformity of employees have been identified and examined based on 39 sources and a model has been presented among them. Results: In this study, authentic studies on social conformity and its manifestation in organizations were identified and categorized into 22 antecedents and 13 consequences of social conformity of employees and a conceptual model was developed for future research of these antecedents and consequences. Research management applications: This model could be used as a new model in the field of antecedents and consequences of social conformity of employees in This study confirms English insertions in the form of nouns and verbs. Here nouns are switched with highest frequency from EL to ML frame and it confirms what is proposed by Myers-Scotton (2002). This data is aligned with many other studies mentioning nouns as the most common form of the codeswitched constituent in a sentence (see Haugen, 1969; Health, 1981; Myers-Scotton, 1993; Naseh, 2002). Target data sets carry unique adjective-noun combinations where Urdu adjectives are used with English nouns and this is prevalent for the most used element “VIRUS”.
THE INTERNATIONAL JOURNAL OF HUMANITIES & SOCIAL STUDIES Determinant Factors of Access to the Internet among in-School Adolescents in Imo State, South-East, Nigeria

of them include cyber bullying, internet pornography, poor reading habits, internet addiction etc. Some parents are of the view that a child should not have access to internet enabled gadgets until they leave secondary school or at least until they are 18 years which is considered the age of adulthood and accountability in many societies of the world. Also, the buoyancy of the Abstract: There are concerns from several quotas about the dangers of allowing young people especially adolescents have access to the internet. Many vices have been linked to young people’s access to the internet; some of them include cyber bullying, internet pornography, poor reading habits, internet addiction etc. The study therefore set out to find out how the socioeconomic status and beliefs of parents affect their in-school adolescents’ access to the internet. The mixed method approach was adopted to achieve the objectives of the study. Questionnaire and Focus Group Discussion (FGD) were used to gather quantitative and qualitative data respectively. While 500 copies of the questionnaire were administered to respondents, 493 copies were retrieved and valid for the study. Six FGD sessions took place. Multi-stage, simple random and systematic sampling techniques were used for the selection of the respondents for the quantitative method. This was because the population of the study cut across the three educational zones of the state and classes. Purposive sampling technique was employed to select participants in the Focus Group Discussion (FGD). This technique was used to select members for the study based on their relevance to the study. The study was anchored on the Technology Acceptance Model (TAM). Findings show that socioeconomic status affect adolescents’ access to the internet while parental beliefs affect their freedom of use. Findings also show that in-school adolescents in Imo State to a very large extent have access to the internet despite the fears of their parents. Based on these findings, the researchers recommended that parents use both technical and physical strategies to monitor what their adolescent children do on the internet since it is obvious that the internet has great potentials and has come to stay and cannot be stopped.
PRBM_A_310266 877..887

1Shanghai Pudong New Area Mental Health Center, Tongji University School of Medicine, Shanghai, 200122, People’s Republic of China; 2Department of Medical Psychology, Changzheng Hospital, Naval Medical University, Shanghai, 200003, People’s Republic of China Aim: The present study examined the experiences of patients diagnosed with COVID-19 to better understand their concerns and inspiration and provide better care. Methods: Semistructured interviews were performed with 10 COVID-19 patients from the Optical Valley Branch of Maternity and Child Healthcare Hospital of Hubei Province. Interviews were recorded on audiotape and transcribed verbatim. Transcripts were analysed using an interpretative phenomenological analysis. Results: Four superordinate themes emerged: psychological distress caused by COVID-19 uncertainty, ethical dilemmas that will be faced after returning to the family and society, resources to cope with COVID-19, and event-related growth experience. Conclusion: Patients with COVID-19 were generally at high risk of having mental and social health challenges. Although the epidemic obviously affected their overall health, which led to their negative emotions or concerns, it also had a positive effect, such as viewing their relationship with families or others more positively and having more thoughts and outlooks on life. The study prompted medical staff to take their time listening to patients and pay more attention to specific psychological and social health problems in future care.
Null Hypothesis Signiﬁcance Testing, p -values, Effects Sizes and Conﬁdence Intervals

There has been controversy over Null Hypothesis Signiﬁcance Testing (NHST) since the ﬁrst quarter of the 20th century and misconceptions about it still abound. The ﬁrst section of this paper brieﬂy discusses some of the problems and limita- tions of NHST. Overwhelmingly, the ‘holy grail’ of researchers has been to obtain signiﬁcant p -values. In 1999 the American Psychological Association (APA) rec- ommended that if NHST was used in data analysis, then researchers should report effect sizes (ESs) and their conﬁdent intervals (CIs) as well as p -values. The APA recommendations are summarised in the next section of the paper. But as neuropsychological rehabilitation clinicians, the primary interest is (or should be) to determine whether or not the effect of an intervention is clinically important, not just statistically signiﬁcant. In this context, ESs and their CIs provide information relevant to clinicians. The next section of the paper reviews common ESs and worked out examples are provided for the calculation of three commonly used ES (Cohen’s d , Hedge’s g and Glass’ delta ). Web-based resources for calculating other ESs and their CIs are also reviewed.