Miracle-dz/UniFAR-FTUs huggingface dataset:
The effect of two easily-implementable modifications in reducing gender disparities in Door-to-Needle time in acute ischemic stroke

Introduction: Door-to-needle (DTN) time is an important factor in managing stroke for which studies have reported delays in women. We aimed to evaluate the effect of some simple modifications on reducing sex disparities, with a focus on DTN. Methods: This longitudinal cohort study was conducted between September 2019, and August 2021, at a comprehensive stroke center. Previously we utilized the conventional “D’s of stoke care” for timely management. Some simple modifications were implemented in September 2020, with a special focus on the time of the neurologist's evaluation (D4-B) and patients’ transfer to the stroke unit (D6-B). Patients were analyzed in two groups: group 1, before, and group 2, after employing the modifications. Sex as the main variable of interest along with other selected covariates were regressed towards the DTN, using univariable and multivariable logistic regressions. Results: We enrolled 47 and 56 patients who received intravenous thrombolysis in groups 1 and 2, respectively. Although there was a significant difference in DTN≤ 1 hour between women and men in group 1 (36% vs. 52%, p= 0.019), it was not significantly different in group 2 (48% vs. 48.4%, p= 0.97). Furthermore, regression analysis showed being female was a significant predictor of DTN> 1 hour in group 1 (aOR= 6.65, p= 0.02), while after employing the modifications gender was not a predictor of delayed DTN. Conclusion: Although we have a long way to achieve performance measures in developed countries, we seem to have succeeded in reducing gender disparities in DTN using these simple modifications.
The Effect of Geographical Factors on Islamic Banking Sustainability Performance: An Instrumental Variable Quantile Regression Analysis

There is an ongoing debate on how Islamic banks contribute to bank sustainability. Theoretically, Islamic ethics promote sustainability, also called Maqasid al-shari'ah. This paper investigates the effect of geographical factors on Islamic bank sustainability. A theoretical and empirical model was developed to assess this relationship. It was hypothesized that geographical factors affect Islamic bank sustainability. Countries in specific geographical locations that are dominated by Islamic rules, such as the Middle East, have different magnitudes compared to east Asian countries that have fewer Islamic rules. A geographical risk model was developed according to the Maqasid al-Shari'ah concept and was employed based on a microeconomic banking model that portrays a variety of risks for 159 Islamic banks in ten countries. We constructed variables from macroeconomic databases, such as the World Development Indicators, and microeconomic databases, such as financial indicators and environmental, social, and governance (ESG) data from Thomson Reuters from 2012 to 2019. The analysis was conducted using panel instrumental variable regression to test the hypothesis; however, geographical risk variables produced biased results affecting Maqasid financing. The method was refined with IV quantile regression. It was found that geographical factors are strongly related to the improvement of Maqasid financing in Middle East regions, whereas in eastern regions this is vice versa. The results indicate that geopolitical factors stimulate Maqasid financing for Sustainable Development Goals.
Consumer awareness and consumption pattern of probiotic & sugar free ice creams in Hyderabad & Secunderabad

Zakat is a significant economic and social instrument for the poverty alleviation. The study presented an analytical justification of the how importance of Zakat to humankind. It is a theoretically dominated empirical study that looked into the analytical views of justification about how Zakat can alleviate poverty from the society. The results of the study disclosed with some concrete justifications that Zakat can be considered as a well being program to establish peace, prosperity and socio-economic development for mankind as a whole all times. However, the study could not consider a good number of numerical examples in favour of the main message of the study because of lack of data availability. Zakat funds can be utilized for the development of resources especially concentrates in the area of human capital development for the long-term rather than short-term relief for those in need. We should aim at using Zakat fund as a means of providing assistance that will have a long lasting effect. This study proposes that if Zakat are fully collected and distributed to the deserving people according to Shariah law, we can expect to root out poverty from the society.
The Use of Screening Tools for Cardiovascular Risk Assessment in Psoriasis – A Case- Control Study

Background: Psoriasis is a common, T-cell-mediated disease, affecting 0.44–2.8% of the general population in India. It is associated with a higher risk of cardiovascular disease possibly due to chronic inflammation. Those patients with severe psoriasis are at a higher risk of death due to cardiovascular disease. The use of scoring tools may help the care providers to assess cardiovascular risks in these patients. Aims: The aim of this study was to assess the cardiovascular risks in patients with severe psoriasis using the commonly used risk-assessment tools (Framingham risk score [FRS] and Pooled cohort equations [PCE]) and to understand the utility of these tools in practice. Methods: It is a case-control study performed in the dermatology outpatient department of a tertiary care center during the study period from January to December 2020. Consenting adults with chronic plaque psoriasis and psoriasis area and severity index (PASI) more than 10 were included in the study. The FRS and PCE risk scores were calculated for the patients and age- and sex-matched healthy controls. Results: A total of 213 patients were assessed and 30 patients were excluded. Of the 183 patients, 152 patients were assessed using FRS and 135 patients using PCE. Equal number of age- and sex-matched healthy controls were also assessed. The mean age of the patients assessed using the FRS and PCE was 47 ± 10.9 and 52.84 ± 8.9 years, respectively. The mean age of the controls was 45.52 ± 8.7 and 51.76 ± 8.1 years in the FRS and PCE groups, respectively. The male to female ratio was 1.92:1 and 2:1 in the FRS and PCE risk-score groups, respectively. The mean PASI score was 16.45 ± 7.88 and 15.6 ± 7.6 in the two groups, respectively. The 10-year risk estimate using FRS in the patients ranged from 0 to 26.9%. The mean and median estimates were 4.95 ± 5.7 and 2.8%, respectively, while 2.65 ± 4.7 and 0.8% in the controls (P = 0.001). The 10-year risk estimate in the patients using the PCE risk score ranged from 0.3 to 39.6%. The mean and median estimate in the patients was 8.17 ± 9.9 and 5.2%, respectively while they were 5.68 ± 7.5% and 2.6% in the controls (P = 0.024). The agreement between the FRS and PCE was found to be poor (Ϗ, 0.049). There was no statistically significant correlation of PASI to either the PCE risk score (P = 0.498) or FRS (P = 0.630). Limitations: A small sample size, and study in a tertiary care center may have resulted in sampling bias. Conclusion: Psoriasis is associated with a higher risk of cardiovascular disease. These tools may help a dermatologist in the primary prevention of cardiovascular disease. It can also help in the awareness of the increased risk of cardiovascular disease in patients.
Uncovering the Burden of Dengue in Africa: Considerations on Magnitude, Misdiagnosis, and Ancestry

Dengue is a re-emerging neglected disease of major public health importance. This review highlights important considerations for dengue disease in Africa, including epidemiology and underestimation of disease burden in African countries, issues with malaria misdiagnosis and co-infections, and potential evidence of genetic protection from severe dengue disease in populations of African descent. The findings indicate that dengue virus prevalence in African countries and populations may be more widespread than reported data suggests, and that the Aedes mosquito vectors appear to be increasing in dissemination and number. Changes in climate, population, and plastic pollution are expected to worsen the dengue situation in Africa. Dengue misdiagnosis is also a problem in Africa, especially due to the typical non-specific clinical presentation of dengue leading to misdiagnosis as malaria. Finally, research suggests that a protective genetic component against severe dengue exists in African descent populations, but further studies should be conducted to strengthen this association in various populations, taking into consideration socioeconomic factors that may contribute to these findings. The main takeaway is that Africa should not be overlooked when it comes to dengue, and more attention and resources should be devoted to this disease in Africa.
Assessing the Effects of Nature on Physiological States Using Wearable Technologies

Nature therapy and forest bathing (FB) have been shown to have quantifiable positive effects on human health, but the physiological effects of a guided interactive nature activity remain unexplored. Autonomic nervous system responses to a guided nature walk (Nature Break) were assessed through the continuous measurement of the electrodermal activity (EDA), fingertip temperature, and heart rate (HR) of n = 48 participants, using a wearable sensor. Psychological distress was assessed before and after the activity using the Profile of Mood States (POMS) for n = 38 (24 females, 14 males, mean age = 43.55 ± 11.61 years) participants. The negative dimensions of POMS decreased and the positive (vigor) dimensions increased following a Nature Break. Significant differences were found across all of the physiological features, with some differences occurring between the morning and afternoon groups and between different days. The participants’ mean HR decreased throughout the Nature Break. Our results suggest that interactive nature activities have positive psychological benefits and demonstrate the feasibility of using wearable sensors to monitor physiological responses in a naturalistic forest bathing activity.
Weighted Multi-Parameter Mixed Hardy Spaces and Their Applications

Applying discrete Calderón’s identity, we study weighted multi-parameter mixed Hardy space Hmixp(ω,ℝn1×ℝn2)\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$H_{{\rm{mix}}}^p(\omega ,{\mathbb{R}^{{n_1}}} \times {\mathbb{R}^{{n_2}}})$$\end{document}. Different from classical multi-parameter Hardy space, this space has characteristics of local Hardy space and Hardy space in different directions, respectively. As applications, we discuss the boundedness on Hmixp(ω,ℝn1×ℝn2)\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$H_{{\rm{mix}}}^p(\omega ,{\mathbb{R}^{{n_1}}} \times {\mathbb{R}^{{n_2}}})$$\end{document} of operators in mixed Journé’s class.
Perception Bias Effects on Healthcare Management in COVID-19 Pandemic: An Application of Cumulative Prospect Theory

Coronavirus disease 2019 (COVID-19) has posed severe threats to human safety in the healthcare sector, particularly in residents in long-term care facilities (LTCFs) at a higher risk of morbidity and mortality. This study aims to draw on cumulative prospect theory (CPT) to develop a decision model to explore LTCF administrators’ risk perceptions and management decisions toward this pandemic. This study employed the policy Delphi method and survey data to examine managers’ perceptions and attitudes and explore the effects of sociodemographic characteristics on healthcare decisions. The findings show that participants exhibited risk aversion for small losses but became risk-neutral when considering devastating damages. LTCF managers exhibited perception bias that led to over- and under-estimation of the occurrence of infection risk. The contextual determinants, including LTCF type, scale, and strategy, simultaneously affect leaders’ risk perception toward consequences and probabilities. Specifically, cost-leadership facilities behave in a loss-averse way, whereas hybrid-strategy LTCFs appear biased in measuring probabilities. This study is the first research that proposes a CPT model to predict administrators’ risk perception under varying mixed gain–loss circumstances involving considerations of healthcare and society in the pandemic context. This study extends the application of CPT into organizational-level decisions. The results highlight that managers counteract their perception bias and subjective estimation to avoid inappropriate decisions in healthcare operations and risk governance for a future health emergency.
Expression Characterization of AtPDI11 and Functional Analysis of AtPDI11 D Domain in Oxidative Protein Folding

The formation and isomerization of disulfide bonds mediated by protein disulfide isomerase (PDI) in the endoplasmic reticulum (ER) is of fundamental importance in eukaryotes. Canonical PDI structure comprises four domains with the order of a-b-b′-a′. In Arabidopsis thaliana, the PDI-S subgroup contains only one member, AtPDI11, with an a-a′-D organization, which has no orthologs in mammals or yeast. However, the expression pattern of AtPDI11 and the functioning mechanism of AtPDI11 D domain are currently unclear. In this work, we found that PDI-S is evolutionarily conserved between land plants and algal organisms. AtPDI11 is expressed in various tissues and its induction by ER stress is disrupted in bzip28/60 and ire1a/b mutants that are null mutants of key components in the unfolded protein response (UPR) signal transduction pathway, suggesting that the induction of AtPDI11 by ER stress is mediated by the UPR signaling pathway. Furthermore, enzymatic activity assays and genetic evidence showed that the D domain is crucially important for the activities of AtPDI11. Overall, this work will help to further understand the working mechanism of AtPDI11 in catalyzing disulfide formation in plants.
Recent Analytical Approaches for the Study of Bioavailability and Metabolism of Bioactive Phenolic Compounds

The study of the bioavailability of bioactive compounds is a fundamental step for the development of applications based on them, such as nutraceuticals, functional foods or cosmeceuticals. It is well-known that these compounds can undergo metabolic reactions before reaching therapeutic targets, which may also affect their bioactivity and possible applications. All recent studies that have focused on bioavailability and metabolism of phenolic and terpenoid compounds have been developed because of the advances in analytical chemistry and metabolomics approaches. The purpose of this review is to show the role of analytical chemistry and metabolomics in this field of knowledge. In this context, the different steps of the analytical chemistry workflow (design study, sample treatment, analytical techniques and data processing) applied in bioavailability and metabolism in vivo studies are detailed, as well as the most relevant results obtained from them.
Surgical Site Cytology to Diagnose Spinal Lesions

Patients with new-onset malignant spinal lesions often have an urgent need for local spine intervention and systemic therapy. For optimal management, it is crucial to diagnose the underlying disease as quickly and reliably as possible. The aim of our current study was to determine the feasibility, sensitivity, specificity, and diagnostic certainty of complementary cytological evaluation of spinal lesions suspected of malignancy. In 44 patients, we performed histopathological biopsies and in parallel cytologic preparations from the malignant site. Cytological smears were prepared and stained for May-Grunwald and Giemsa. Bone biopsies were histopathologically analyzed according to the existing standard-of-care practices. In 42 of 44 cases (95%), a cytological sample was successfully obtained. In 40 cases (95.2%, Cohen’s kappa: 0.77), the cytological diagnosis agreed with the histological diagnosis regarding the identification of a malignant lesion. This resulted in a sensitivity of 97% and a specificity of 80% as well as a diagnostic safety of 95%. Cytological analysis in the context of spinal surgery proved sufficient to establish a diagnosis of malignancy or its exclusion, expanding the existing diagnostic spectrum. Furthermore, implementation of this process as a routine clinical diagnostic might shorten the time to diagnosis and improve the treatment of this vulnerable patient group.
Lysyl oxidase promotes anaplastic thyroid carcinoma cell proliferation and metastasis mediated via BMP1.

Background Anaplastic thyroid carcinoma (ATC) is an extremely aggressive solid tumor with no effective treatment at present. Because of the rapid growth and aggressiveness, nearly all patients die within six months after developing ATC. Hence, more research regarding novel therapeutic targets for ATC is urgently needed. Methods Single-cell RNA sequencing data and microarray data of ATC were retrieved from the Gene Expression Omnibus (GEO) database. Cell clustering was performed using the Seurat package. Then, differential expression and functional enrichment analyses were performed. Gene set enrichment analysis (GSEA) was further used to investigate the functional enrichment of lysyl oxidase (LOX) and bone morphogenetic protein-1 (BMP1). The expression levels of LOX and BMP1 were measured using quantitative real-time PCR and Western blot. LOX and BMP1 were knocked down using si-RNAs. Cell proliferation was evaluated by the CCK-8 and clone formation assays. Cell migration and invasion were assessed by the wound healing assay and Transwell assay, respectively. Results LOX was upregulated at the single-cell level, as well as in ATC tissues and cell lines. LOX knockdown significantly inhibited ATC cell proliferation. Furthermore, the migration and invasion of ATC cells were remarkably inhibited after LOX inhibition. In addition, BMP1 regulated LOX expression in 8505C cells, while BMP1 overexpression restored the LOX activity blocked by the LOX inhibitor BAPN. BMP1 could also induce the cell proliferation and metastasis of ATC. Conclusions LOX/BMP1 mediates the malignant progression of ATC, highlighting the potential application of LOX/BMP1 in the treatment of ATC. This study provides new insights for efficient therapeutic agents based on the LOX/BMP1 axis.
Burnout Assessment Tool (BAT): Validity Evidence from Brazil and Portugal

The Burnout Assessment Tool (BAT) has been gaining increased attention as a sound and innovative instrument in its conceptualization of burnout. BAT has been adapted for several countries, revealing promising validity evidence. This paper aims to present the psychometric properties of the Brazilian and Portuguese versions of the BAT in both the 23-item and 12-item versions. BAT’s validity evidence based on the internal structure (dimensionality, reliability, and measurement invariance) and validity evidence based on the relations to other variables are the focus of research. A cross-sectional study was conducted with two non-probabilistic convenience samples from two countries (N = 3103) one from Brazil (nBrazil = 2217) and one from Portugal (nPortugal = 886). BAT’s original structure was confirmed, and it achieved measurement invariance across countries. Using both classic test theory and item response theory as frameworks, the BAT presented good validity evidence based on the internal structure. Furthermore, the BAT showed good convergent evidence (i.e., work engagement, co-worker support, role clarity, work overload, and negative change). In conclusion, the psychometric properties of the BAT make this freely available instrument a promising way to measure and compare burnout levels of Portuguese and Brazilian workers.
The Retrievability of Calcium Silicate-Based Sealer during Retreatment and the Effectiveness of Additional Passive Ultrasonic Irrigation: A Microcomputed Tomographic Study

This study investigated the retreatability of EndoSeal MTA (Maruch, Wonju, Korea) according to the presence or absence of a canal isthmus and the additional use of passive ultrasonic irrigation (PUI) through microcomputed tomography (micro-CT) imaging. An epoxy resin sealer (AH Plus (Dentsply DeTrey, Konstanz, Germany)) was used as a reference for comparison. Forty-five artificial mandibular molars (TRUETOOTH #19, DELABS, Santa Barbara, CA) with a mesial canal with an isthmus and a distal canal without an isthmus were obturated using gutta-percha and one of the following sealers (n = 15 each): AH Plus, EndoSeal MTA, and EndoSeal MTA + PUI. Micro-CT scanning was performed to assess the void volume (as a percentage) at three root levels. After the root fillings were removed, second micro-CT scanning was conducted to evaluate the amount of remaining root filling material. The Kruskal-Wallis H test and post hoc analysis were used for between-group comparisons. The Mann–Whitney U test was used for comparisons between canals with and without an isthmus (p < 0.05). In the EndoSeal MTA group, the void volume and remaining filling materials were higher irrespective of the presence or absence of an isthmus. In apical lesions in the EndoSeal MTA group, the void ratio was significantly lower, and there was a significantly higher amount of remaining filling material. Regardless of the presence of an isthmus, the amount of remaining filling material of the EndoSeal + PUI group was reduced to a similar degree as the AH plus group. When performing retreatment for root canals filled with EndoSeal MTA, removal of the filling material can be more difficult in the apical region. The additional use of PUI can improve the efficacy of removal.
Experimental Investigation on Turbulent Flow Width around Bridge Pier

For lack of method calculating turbulent flow width around bridge pier in the recent "Inland river navigation Standard"(GB50139-2004) of China,bridge designers usually increase the spans of bridge for navigation safety,which will increases both of structure design difficulty and project investment.So,it is extremely essential to do the research on turbulent flow width around bridge pier.Through fixed bed and mobile bed experiments in water tank,the factors such as approaching flow speed,approaching water depth,flow angle of incidence,sizes of bridge pier,shape of bridge pier,scouring around bridge pier etc.that influence the turbulent flow width around bridge pier are analyzed.Dimensional analysis method is used for data processing and the formula calculating the turbulent flow width around bridge pier is obtained.