Miracle-dz/UniFAR-FTUs huggingface dataset:
Mri-Based Assessment Of Cortical Bone Matrix And Mineral Properties In A Clinical Setting

As a pathological condition primarily afflicting the elderly, osteoporosis is becoming more prevalent with today’s lengthened life expectancy. Osteoporosis-associated fractures are dangerous, often associated with lethal complications, and impose a huge economic burden on society. Unfortunately, current techniques used to diagnose the disease cannot provide reliable fracture risk prediction, as they rely upon apparent bone mineral density (BMD) only. Recent advances in short echo time (TE) imaging have made it possible to examine different properties of bone with magnetic resonance imaging (MRI). Water bound to the collagen matrix (bound water, BW), water residing in the pore space (pore water, PW), and phosphorus (31P) in bone mineral crystals have previously been proposed as surrogate markers for bone matrix density, porosity and mineral density, to be quantitatively imaged with either 1H or 31P ultra-short TE (UTE) or zero TE (ZTE) sequence. In this dissertation, an integrated MRI protocol measuring both bone matrix and mineral properties in vivo was first designed and tested with clinical hardware. MRI-derived PW was negatively correlated with high resolution peripheral quantitative computed tomography (HR-pQCT) derived BMD, while bone mineral content based on MRI-derived phosphorus density was positively correlated with that based on HR-pQCT BMD. Second, in vivo bone phosphorus relaxation times were studied in a small cohort of healthy volunteers (aged 29 to 65). The relative invariability of relaxation properties obviated the need for individual measurements in this healthy cohort. Third, gradient imperfections were found to introduce errors in UTE image-based bone water quantification and to undermine measurement agreement across scanners, therefore requiring correction. Finally, the suggested protocol was applied in an ongoing osteoporosis treatment study. Expected observations –– elevated pore water, lowered bound water and phosphorus densities –– were observed in the patient group relative to healthy controls in limited baseline data acquired thus far. In conclusion, this dissertation proves the feasibility of measuring bone matrix and mineral surrogates in a clinical setting, and may aid in better predicting osteoporotic fractures. Degree Type Dissertation Degree Name Doctor of Philosophy (PhD) Graduate Group Bioengineering First Advisor Felix W. Wehrli Second Advisor Hee Kwon Song
Dyadic, Self-Administered Cognitive Intervention for Healthy Older Adults: Participants’ Perspectives

ABSTRACT Dyadic, home-based wellness interventions may reach older adults with transportation, mobility, scheduling, and caregiving barriers. This qualitative study aimed to examine participants’ experiences with dyadic cognitive training. Participants (n = 14; age M = 74.36) completed self-administered, paper-and- pencil cognitive training where they took turns training one another. The dyads included spouses, friends, neighbors, and previously unfamiliar adults. Post- intervention interviews were analyzed. Individuals reported that intervention flexibility overwhelmingly contributed to their ability and willingness to participate in the program. Thus, dyadic format is accessible, flexible, and relatively low cost, and may be applicable to a variety of behavioral interventions in aging.
Methodological issues in the analysis of the socioeconomic determinants of health using EU-SILC data

Health inequalities across socioeconomic groups are a health and public policy concern in all countries. There exist robust methodological tools from the epidemiological and economics disciplines to measure inequalities in health and there is a substantial amount of evidence on the level of inequalities in health across countries. However, there are numerous methodological issues that the study of health inequalities introduces. In this article we discuss the potential reporting bias and the alternative methods included in other health surveys to correct for this issue. Secondly, we distinguish between short-term and long-term concentration index (CI), exploiting the longitudinal data included in EU-SILC. Thirdly, we discuss the corrected CI suggested by Erreygers (2009) to overcome the limitations of the �old� CI. Finally, we conclude with an analysis of unmet needs for medical and dental examination or treatment and their main reasons, using the data available in EU-SILC.
Yield of comparative genomic hybridization microarray in pediatric neurology practice

Objective The present study investigated the diagnostic yield of array comparative genomic hybridization (aCGH) in a large cohort of children with diverse neurologic disorders as seen in child neurology practice to test whether pathogenic copy number variants (CNVs) were more likely to be detected in specific neurologic phenotypes. Methods A retrospective cross-sectional analysis was performed on 555 children in whom a genetic etiology was suspected and who underwent whole-genome aCGH testing between 2006 and 2012. Neurologic phenotyping was performed using hospital medical records. An assessment of pathogenicity was made for each CNV, based on recent developments in the literature. Results Forty-seven patients were found to carry a pathogenic CNV, giving an overall diagnostic yield of 8.59%. Certain phenotypes predicted for the presence of a pathogenic CNV, including developmental delay (odds ratio [OR] 3.69 [1.30–10.51]), cortical visual impairment (OR 2.73 [1.18–6.28]), dysmorphism (OR 2.75 [1.38–5.50]), and microcephaly (OR 2.16 [1.01–4.61]). The combination of developmental delay/intellectual disability with dysmorphism and abnormal head circumference was also predictive for a pathogenic CNV (OR 2.86 [1.02–8.00]). For every additional clinical feature, there was an increased likelihood of detecting a pathogenic CNV (OR 1.18 [1.01–1.38]). Conclusions The use of aCGH led to a pathogenic finding in 8.59% of patients. The results support the use of aCGH as a first tier investigation in children with diverse neurologic disorders, although whole-genome sequencing may replace aCGH as the detection method in the future. In particular, the yield was increased in children with developmental delay, dysmorphism, cortical visual impairment, and microcephaly.
Quadriceps muscle strength after training with a cycloergometer in patients on hemodialysis

Abstract Introduction: Functional disability is common in patients with chronic kidney disease, especially in those on hemodialysis. Muscle strength can be evaluated by a dynamometer; however, no study using this technique on the quadriceps of patients undergoing hemodialysis was found in literature. Objective: To assess the effects of cycloergometer training on the quadriceps muscle strength of patients with chronic kidney disease undergoing hemodialysis. Method: This was a clinical trial including 46 patients, both men and women, over 18 years old who had been undergoing hemodialysis for more than six months and signed an informed consent form. Patients were allocated into two groups: intervention group (n = 22) and control group (n = 20). The intervention group underwent intradialytic training in a physical therapy protocol with the cycloergometer for two months, whereas the control group, in turn, was only reevaluated two months after the initial evaluation. All patients were assessed for demographic data at baseline and, two months later for quadriceps muscle strength by standardized dynamometry and with the use of a rigid belt and suction cups. Results: A significant increase was detected in quadriceps muscle strength in the right and left lower limbs in the intervention group when compared with the control group. Conclusion: Quadriceps muscle strength improved after patients with chronic kidney disease on hemodialysis underwent training with the cycloergometer.
The effect of low dose aspirin intake on gastro-duodenal mucosa, and protective effects of GSH-vitamin C-E

Objectives: Neutrophil-mediated inflammation and oxidative stress may be the important events that lead to gastroduodenal mucosal damage induced by aspirin. It is hypothesized that GSH-vitamin C-E may protect to the upper gastrointestinal mucosa against low dose aspirin’s (L-ASA) adverse effects. Material and methods: Male rats were fed regular diets and maintained for 40 days in the control group (n=8), the L-ASA group (n=8), which was given aspirin (1.44 mg/kg/ day) administered intragastrically by feeding tube to rats, or the L-ASA with antioxidant supplement group (n=8), to whom 1.44 mg of aspirin/kg/day + a solution that contained 50 mg vitamin C, 25 mg vitamin E and 25 mg GSH was administered intragastrically by feeding tube to rats every day. After the treatments, blood, stomach and duodenum were taken for pathological and myeloperoxidase (MPO) activity, heat shock protein (Hsp) 70, lipid and protein oxidation analyses. Results: The stomach and duodenum of the L-ASA group rats had higher scores of pathological findings compared with the control group, whereas the severity of the lesions was found low in the antioxidant-supplemented group according to the L-ASA group. In addition, the gastric mucosal MPO activity and Hsp 70 levels in the L-ASA group were significantly higher than control, but antioxidant supplementation lowered the values of MPO and Hsp 70 in the antioxidant supplemented group (P=0.009, P=0.04). Conclusion: A simultaneous intake of GSH-vitamin C-E along with aspirin attenuated the gastric injury. GSH-vitamin C and E could play a protective role in the stomach against gastric damage resulting from low dose daily long-term aspirin use.
Phrenic nerve injury during cryoballoon ablation for paroxysmal atrial fibrillation originating from the superior vena cava

Cryoballoon (CB) has emerged as a reasonable alternative to radiofrequency for treatment of paroxysmal atrial fibrillation (AF) due to simple operation, short learning curve, less patient discomfort, shorter ablation time, etc., However, the second-generation CB had a higher probability than the first-generation CB in the phrenic nerve injury (PNI) mostly observed in freezing the right superior pulmonary vein. Few reports on the CB ablation for a refractory AF originating from superior vena cava.what's more,It is rare to publish Phrenic Nerve Injury(PNI) is occurred in CB ablation for AF from SVC,the case is about it.
Le medicament du mois. Ivabradine (Procoralan).

L'ivabradine (Procoralan ® ), un nouvel inhibiteur specifique du courant pacemaker I f qui agit en fonction de la dose sur l'activite pacemaker du noeud sino-auriculaire, est un agent bradycardisant pur. Elle ralentit la pente de depolarisation diastolique lente des cellules du noeud sino-auriculaire et diminue la frequence cardiaque au repos et a l'effort. Chez les patients souffrant d'angor stable, l'ivabradine presente des proprietes anti-ischemiques et anti-angineuses aux doses recommandees de 5 et 7,5 mg deux fois par jour. Elle est par ailleurs, chez ces patients, aussi efficace que l'atenolol et l'amlodipine pour empecher ou attenuer l'ischemie induite par l'effort. La prise d'ivabradine est habituellement bien toleree, les symptomes visuels etant les principaux effets indesirables. Ces symptomes sont lies a la presence dans la retine de canaux ioniques semblables aux canaux I f , Ils sont souvent transitoires et n'affectent pas la tolerance au traitement. En Belgique, l'ivabradine est actuellement remboursee chez les patients souffrant d'angor stable qui sont en rythme sinusal et qui ne tolerent pas les beta-bloquants et les antagonistes calciques bradycardisants ou chez qui ces traitements sont contre-indiques.
The Clinical and Radiological Characteristics of Male Patients who Underwent Vertebroplasty Due to Osteoporotic Compression Fracture

Objective: To investigate the clinical characteristics of male population who underwent vertebroplasty for osteoporotic compression fracture and evaluate the clinical, radiological outcomes compared to female group. Methods: The medical records and radiological data were reviewed in total 155 patients who underwent vertebroplasty for osteoporotic vertebral compression fracture from February 2006 to November 2009. We compared 32 male patients with 123 female patients in terms of preoperative factors, intraoperative factors, and clinical and radiologic outcomes. Results: The mean age of male group was 67.8±8.6 years and their mean T-score on bone mineral density (BMD) was -3.2±0.8. The mean age of female group was 71.8±8.9 years and their mean T-score was -3.7±0.7 (p=0.025 for age, p=0.002 for BMD). Male patients (21 out of 32, 65.6%) had more frequent traumatic event than female patients (51 out of 123, 41.5%) (p=0.012). The secondary osteoporosis was more frequently seen in male group than female group (53.1% vs 26.8%, p=0.005). The lump cement distribution pattern was found more frequently in male group than female group (46.9% vs 28.5 %, p=0.040). There was no statistically significant difference between the two groups in clinical outcomes. Conclusion: Male patients had significantly more risk factors for secondary osteoporosis and obvious traumatic event than female group. Clinicians should always be aware of secondary causes of osteoporosis and history of traumatic events in male patients with osteoporotic compression fracture and also pay attention to correct the cause of secondary osteoporosis and recommend anti-osteoporosis management.
Toxicology of Organophosphate Nerve Agents

The organophosphate (OP) anticholinesterases include the chemical warfare nerve agents, a variety of OP pesticides (Ballantyne and Marrs, 1992) and, less well-known, a natural compound, anatoxin-As (Dittmann and Wiegand, 2005). The active ingredients of OP pesticides are used as drugs in human medicine, e.g. malathion to treat head-lice and metrifonate/trichlorfon in tropical medicines. OPs are also used in veterinary medicine notably as ectoparasiticides (Beesley, 1994). The chemical warfare nerve agents have a much higher mammalian acute toxicity, particularly via the percutaneous and inhalation routes, than the OP pesticides. Additionally many chemical warfare agents are phosphonofluoridates and phosphonothioates, while many pesticides are = S type-phosphorothioates. Qualitatively, the anticholinesterase toxicology of the OP nerve agents and pesticides is similar and in general treatment strategies are alike so that much information on OP pesticides is relevant to nerve agent toxicology.
Response of wheat (Triticum aestivum) varieties to sowing dates in Gird region of Madhya Pradesh

Afield experiment was conducted at Gwalior, India during rabi season 2011–12 to assess the response of wheat (Triticum aestivum L.) varieties to sowing dates. Significantly higher grain yield (60.82 q ha−1) was obtained from wheat variety HI 8498 sown on 18th November over other varieties on same date ofsowing. The early sowing (11th November)gave 6.37% less grain yield compared to normal date (18th November). The delayed sowing reduced the grain yield by 13.35% than normal date of sowing. Wheat variety HI 8498 had significantly higher protein content (12.75%) in grain over others. Similarly, early sown crop produced higher protein content compared to normal and delayed sown crop. All wheat varieties sown on 18th November registered the highest gross return, net return and net benefit: cost ratio than the crop sown on 11th and 25th November. Wheat variety HI 8498 when sown on 18th November (D2 V3) produced the highest gross return ( 112324 ha-1), net return ( 95410 ha-1) and benefit: cost ratio (5.64). However, the treatment combination D3V1 (variety GW 366 sown on 25th November) gave the lowest net returns and benefit: cost ratio.
COMPARING CLOBAZAM WITH DIAZEPAM IN PREVENTING FEBRILE SEIZURE IN CHILDREN: A RANDOMIZED CLINICAL TRIAL

Background and purpose: Febrile seizure is a seizure associated with fever without any evidence of intracranial infection or electrolytic disorder. Its treatment includes anticonvulsant medicines administered for preventing recurrence. In this research, treatments with diazepam and clobazam were evaluated in preventing febrile seizure recurrence among patients admitted to Taleghani Hospital. Material and Methods: The study population included 150 patients with simple febrile seizure aged between six months to six years of old. They were randomly assigned into two groups to receive either diazepam or clobazam after control of seizure. The patients received diazepam 0.33 mg/kg/ dose every 8h and clobazam in 2.5, 5, 7.5, and 10 mg/kg every 12 h. The results involving fever episodes in each 3 months, side effects of medicines and recurrence were recorded in a check list and then analyzed. Results: Among the patients 32 were excluded and 118 patients including 61 in diazepam group and 57 in clobazam group were studied. There were 62 males and 56 females in this population. The mean age was 21.05±10.10 months and 21.96±10.74 months in diazepam and clobazam groups, respectively and 21.49±10.39 in total population. There was no significant difference between the two groups in recurrence of febrile seizure (P>0.05). No significant difference was found in incidence of ataxia between the two groups. In the group receiving diazepam 45.9% of the patients had drowsiness compared to 8.8% in clobazm group (P>0.05). No significant difference was found between the studied groups for medicinal side effects including ataxia, vomiting, anorexia, and irritability (P>0.05). Conclusion: Treatment by clobazam caused recurrence and complications less than diazepam. However, more studies including larger sample sizes are required to confirm these results.
Cortical developmental abnormalities in logopenic variant primary progressive aphasia with dyslexia

Abstract An increased prevalence of dyslexia has been observed in individuals diagnosed with primary progressive aphasia, most notably the logopenic variant primary progressive aphasia. The underlying pathology most commonly associated with logopenic variant primary progressive aphasia is Alzheimer’s disease. In this clinical case report series, we describe the neuropathological findings of three patients with logopenic variant primary progressive aphasia and developmental dyslexia, each demonstrating a pattern of cerebrocortical microdysgenesis, reminiscent of findings first reported in dyslexic individuals, alongside expected Alzheimer’s disease pathology. Neurodevelopmental and most severe Alzheimer’s disease pathological changes overlapped within perisylvian brain regions, areas associated with phonological deficits in both logopenic variant primary progressive aphasia and dyslexia. These three cases with pathological findings support the hypothesis that early-life neurodevelopmental changes might influence later-life susceptibility to neurodegenerative disease and could contribute to non-amnestic, early age-of-onset presentations of Alzheimer’s disease. Larger studies investigating neurobiological vulnerability across the lifespan are needed.
Using sensors to estimate intraocular pressure: a review of intraocular pressure telemetry in clinical practice

ABSTRACT Introduction: If intraocular pressure (IOP) is the sole modifiable risk factor for glaucoma progression, glaucoma management should not rely on a vague estimation of its value measured over seconds, out of the 31,536,000 seconds in a year. A technology that would allow continuous and accurate IOP measurement in any situation could drastically enhance the diagnosis, treatment, follow-up and advice we give glaucoma patients. Areas covered: This review covers the development history of IOP telemetry devices, from Green and Gilman’s first 24-hour telemetry concept in 1974 to the two devices commercially available today: Sensimed’s TriggerFish contact lens sensor and Implandata’s implantable monitoring device. Through a systematic review of the articles indexed by the US National Library of Medicine National Institute of Health between November 1969 and July 2019 with the keywords ‘telemetry’, ‘continuous iop’ and ‘24 hour iop’, it details the ongoing contribution of telemetry to glaucoma knowledge. Expert opinion: The usage and purpose of the currently available telemetry devices remain specific and targeted. However, we foresee that this is likely to change in the upcoming years, with the advent of new, more versatile devices and ergonomic modules. The future of telemetry may lie in miniaturization, connectivity and new organic measures.
Several Infra-cranial Non-metric Variations in a Single Neolithic individual: A Common Genetic Underlying Predisposition?

Non-metric variations have been the subject of anatomical and anthropological studies for more than a century. In this study, we present an individual from Sion (Canton of Valais, Southern Switzerland) dated from the Middle Neolithic who shows evidence for four nonmetric variations. This young adult male presents an os acromiale , spondylolysis, a bipartite
Effect of Regular Practicing Bharatnatyam Dancing Exercise on Body Fat of Urban Female Teenagers

Recently for obesity management approach, body fat has got the prime importance as because it has been identified not the body weight but actually the body fat plays the crucial role for predisposition of various metabolic diseases. To address the problem, regular practicing physical activity is a growing choice. On the other hand, dance is a traditional form of recreational activity involving different body movements and requiring body flexibility. From this point of view, present work has been designed to study the impact of receiving training on Bharatnatyam dancing and practicing it regularly as an exercise on body fat in female teenagers of Kolkata. It has been found that individuals receiving Bharatnatyam dancing training for at least a period of five years and practicing it regularly for at least a period of half an hour have significant favorable value of body fat compared to their age and gender matched individuals of similar socioeconomic condition leading otherwise sedentary lifestyle.
Short Term Effect of Low Carbohydrate Diet in Diabetic Male Patients

Background: Low Carbohydrate Diet (LCD) and Calorie Restriction (CR) have been discussed for long. Authors have continued clinical research on LCD, CR and M value. Subjects and Methods: Subjects were 67 male patients with type 2 diabetes mellitus (T2DM). Methods were i) daily profile of blood glucose, average glucose, M value for CR meal, ii) same exam of i) after 2 days of LCD, iii) Delta and AUC ratio for 70g of carbohydrate (0 - 30 minutes) in meal tolerance test (MTT), iv) Triglyceride check for 12 days of LCD, v) analyses of correlation of biomarkers. Results: Obtained data were as follows: average age 61.2 years old, median values are HbA1c 7.8%, fasting glucose 151 mg/dL, IRI 4.4 μU/mL, HOMA-R 2.1, HOMA-β 15.9, respectively. Median values on day 2 vs 14: average glucose 198 vs 151 mg/dL, M value 134 vs 14.4, respectively. AUC ratio for Carbo70 showed more separate distribution as insulin secretion ability than Delta ratio. There were significant correlations among HbA1c, average glucose and M value. Discussion and Conclusion: These results suggested that LCD would have beneficial effects for glucose variability. Furthermore, it would become basal and reference data for the future research development in this field.
Detection and Quantification of Bacterial Flora in Dental Unit Water Systems and the Effect of Flushing on its Reduction

Mansourian A. , Momen Beitollahi J., Jabalameli F. , Tohidast akrad Z. , Basir Shabestari S. , Khorshidian A. , Bahmei Z. a Dept. of Oral Medicine, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran b Dept, of Microbiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran c Dept. of Oral Medicine, School of Dentistry, Qazvin University of Medical Sciences, Qazvin, Iran d Dentist