Miracle-dz/UniFAR-FTUs huggingface dataset:
The Impact of hemodialysis and continuous peritoneal dialysis on lipoprotein(a) concentration and Apolipoprotein(a) Phenotypes in Patients with End Stage Renal Disease

Back ground: Elevated the concentration of lipoprotein(a) [lp(a)] and apolipoprotein(a) [apo(a)] phenotypes are an independent risk factor for coronary heart disease (CHD). Aim: investigation of lp(a) levels and apo(a) phenotypes in relation to coronary heart disease (CHD) and the effect of dialysis on serum lipoprotein(a) concentration according to apo(a) phenotype in patients with end-stage renal disease (ESRD). Patients and methods: This is a case control study among patients attending hospitals and medical dialysis centers in Khartoum capital of the Sudan in March 2011. There were 60 normal healthy subjects (controls), 34 hemodialysis (HD) patients and 29 continuous peritoneal dialysis (CPD) patients. Lipid profiles, Lp(a), and apo(a) phenotypes were determined. Results: The frequencies of the subjects with apo(a) phenotypes of high molecular weight (HMW) only, including S4, or S5 or null type were 96.3% of control, 98.2% of HD patients, and 93% of CPD patients. The frequent apo(a) phenotypes in patients consisted of S4, S4S5, S5, and S5S5 isoforms. There were significant different when compared mean levels of Lp(a) concentration between HD and CPD patients and controls [36±8.0 mg/dL; 38±9.0 mg/dL and 18±2.0 mg/dL respectively P<0.05]. The levels of total cholesterol and LDL cholesterol and ApoB levels were higher in CPD patients compared to HD patients. The levels of serum albumin was significantly higher in controls than in HD and CPD patients [4.4±0.3g/L; 4.0±0.4g/L 3.2±0.7g/dL respectively, P<0.05]. Conclusion: In (ESRD) patients the levels Lp(a) was increased mainly in CPD patients compared to HD patients and control subjects for common apo(a) phenotypes, which may contribute to the frequent cardiovascular. [Ahmed Mohammed Ahmed, Bader Eldien H. Elabid, Abdelrahman Abdelwahab Rhmtallah, Hussein Yousif Eledum, Akram H. Awadalla Hisham Ali Waggiallah. The Impact of hemodialysis and continuous peritoneal dialysis on lipoprotein(a) concentration and Apolipoprotein(a) Phenotypes in Patients with End Stage Renal Disease. J Am Sci 2014;10(8):40-45]. (ISSN: 1545-1003). http://www.jofamericanscience. org. 5
MANAGEMENT CONTROL SYSTEMS AND PERFORMANCE: ESSAY OF MODELLING

Our objectives through this research are multiple. The first objective is to analyze the evolution of management control concept in the scientific literature. The second objective of this work is to propose a general model of performance, which incorporates not only the traditional model of management control but also an interactive module that aims to shed light on the proper role of management control in the emergence of strategy; thus leading to a superior performance.
NEPHROPROTECTIVE ACTIVITIES OF THE METHANOL LEAF EXTRACT AND FRACTIONS OF MOMORDICA BALSAMINA LINN. IN ALBINO RATS

Background: Previous studies have shown that methanol leaf extract of Momordica balsamina Linn. (Cucurbitaceae) can ameliorate renal diseases and injuries in gentamicin-induced nephrotoxicity albino rats. The aim of the study was to investigate the nephroprotective activities of methanol leaf extract and fractions of Momordica balsamina Linn. (Cucurbitaceae) in albino rats. Methods: Fifty-four male albino rats weighing between 100 ± 10g were randomly divided into nine groups of six rats per group. Group I served as a normal control while the other eight groups were administered intra-peritoneally with gentamicin (80 mg/kg body weight per day) for seven days to induce nephrotoxicity. Group II served as nephrotoxic (experimental) control. Group III was subsequently treated with the standard drug (Furosemide, 80 mg/kg body weight per day). Methanol leaf extract, fractions I and II of the leaf extract of M. balsamina Linn. at a daily dose of 200 and 400 mg/kg body weight respectively were used to treat group IV and V, VI and VII and VIII and IX separately. All treatments were carried out by oral gavages for fourteen (14) consecutive days. Assays of renal function biomarkers such as serum electrolytes profile (Na + , K + , Cl and HCO3 ), Urea, Creatinine, Blood Urea Nitrogen (BUN), as well as Total Protein and histopathological examination were also carried out. Results: Results obtained showed that gentamicin administration induced nephrotoxicity in albino rats which were characterized by significant (P<0.05) elevation of all renal injury biomarkers (Urea, Creatinine and BUN concentrations), increased serum electrolytes (Na + , K + and Cl ) and renal tubular necrosis when compared with the normal control group. However, oral World Journal of Pharmaceutical Research SJIF Impact Factor 8.074 Volume 8, Issue 1, 1522-1544. Research Article ISSN 2277– 7105 Article Received on 22 Nov. 2018, Revised on 12 Dec. 2018, Accepted on 02 Jan. 2019 DOI: 10.20959/wjpr20191-14020 *Corresponding Author
Taguchi based Particle Swarm Optimization of Kerf Taper in Laser Cutting of Inconel-718 Sheet

Now a day’s material science works to research and develops the different advanced material such as super alloy, Ceramics and composite. The application of advanced materials is increasing day by day in the field of Automobile, Aviation, Medical and Defense industries also due to their higher properties. The precision in machining of Advanced material is highly required that cannot be achieved by traditional machining method. To achieve the precision in machining of advanced material, the advanced machining process is required. The Laser beam machining is an advanced machining method, broadly used to machine advanced materials like nickel, titanium and other advanced material. Machining of Inconel-718 is one of the exciting jobs in the earlier due to its higher properties. Selection of process parameters in the laser cutting to harvest the preferred level of achievement measures like Kerf Taper (KT) from the quality and economic viewpoints. In the present work, an effort has been made to examine the effect of Laser cutting process parameters such as Gas Pressure (GP), Standoff distance (SOD), Cutting speed (CS) and Laser Power (LP) on Kerf Taper in the cutting of Inconel-718 sheet. The experiments have been conducted by using well planned orthogonal array L27. The second order regression model has been developed for the Kerf Taper (KT) by using the experimental data. The significance of process parameters are estimated by analysis of variance and these results show that the developed model is reliable for predicting the Kerf Taper. Particle swarm optimization method has been used for the optimization of Kerf Taper. The optimum result obtained by the methodology has been validated with the experimental data. The comparison result shows about 66% improvement in Kerf Taper as compared to initial parameters setting. Keywords— Laser cutting; Top Kerf taper; ANOVA; Regression modeling; Particle swarm optimization;
A Note on Two Different Definitions of Reference Surface of Deformed Rubber-Like Shells

The mid surface of undeformed rubber-like shells undergoing finite rotations and finite strains has been considered to be the reference surface of the undeformed configuration. There have been two different definitions for the reference surface of deformed rubber-like shells, undergoing finite rotations and finite strains, used by several researchers. In this study, some comments on the stress-resultants defined relative to the mentioned two reference surfaces of deformed incompressible rubber-like shells under axisymmetrical effects, considering transverse normal and transverse shear deformations, are presented.
Compensation and Employee Performance of Bank in Port Harcourt, Nigeria

-This study was designed to examine the relationship between compensation and Employee Performance of banks operating in Port Harcourt. Among the statement of the problem is the need to explore how banks could leverage on compensation as a strategy to remain competitive in business by retaining high performing staff. This is at a time when there exist other lucrative industries both locally and globally capable of absorbing such staff, especially with the ongoing advocacy and support programmes aimed at encouraging creative young minds to become their own boss. It was based on this backdrop that the reinforcement and expectation theory was adopted as the theoretical foundation for this study. Then utilized a cross sectional survey design as the research methodology as structured questionnaire was distributed to one hundred and forty nine staff of five selected banks and one hundred and twenty were retrieved from the field. With the aid of mean, standard deviation and Pearson Product Correlation Coefficient were utilized as the analysis technique, aided by statistical package for social sciences. Findings from the research revealed that compensation relates positively and significantly with employee performance, as it has significant impact on job satisfaction, employee productivity and employee efficiency. Therefore, it was recommended that compensation is a strategic tool management can leverage on to enhance employee performance and it should be positively utilized as a veritable tool to improve motivation to work better.
EUGENOL AMELIORATES FREUND’S ADJUVANT INDUCED ARTHRITIS IN MALE RATS

Background: Rheumatoid arthritis (RA) is a chronic relapsing autoimmune disorder. Eugenol, a main component of clove oil, possesses potent anti-inflammatory and antioxidant activity. Present investigation was designed to evaluate anti-arthritic potential of eugenol in Freund’s Complete Adjuvant (FCA) induced arthritis in male albino rats. Materials and Methods: Thirty two male albino rats were used. Eight male rats were used as a normal control group received saline (group 1). Arthritis was induced in the 24 male albino rats by intradermal injection of 0.1 ml of FCA in the right hind paw (arthritic animals). Animals were divided into 3 groups. Arthritic control received sesame oil oral (group 2). Arthritic animals treated with indomethacin, it was used as a standard, 2 mg/kg/day orally (group 3). Arthritic animals treated with eugenol 250 mg/kg/day orally (group 4). Fourteen days after immunization, treatment was started with eugenol till 28 days. Results: arthritic control animals showed significant elevation in serum level of C-reactive protein (CRP), nitric oxide (NO), malondialdehyde (MDA) and tumor necrosis factor-α (TNF-α) compared to normal control group. Treatment with eugenol exhibited significant reduction in serum level of CRP, NO, MDA and TNF-α compared with arthritic control group. Conclusion: Therefore, eugenol ameliorates experimental arthritis and could be useful as a beneficial supplement in treating human arthritis.
Postnatal Follow-Up of Newborns with Prenatal Diagnosis of Isolated Hydronephrosis

Sylvia Foldi1, Rima Krawitsky2, Renata Yakubov3, Erez Nadir1, Amit Hochberg1 and Michael Feldman1 1Department of Neonatology, Hillel Yaffe Medical Center, Israel 2Department of Radiology, Hillel Yaffe Medical Center, Israel 3Department of Pediatrics, Hillel Yaffe Medical Center, Israel Submission: February 06, 2017; Published: March 28, 2017 *Corresponding author: Sylvia Foldi, Department of Neonatology, Hillel Yaffe Medical Center, P.O. Box 169, Hadera , 38100 Israel, Tel: ; Fax: +972-4-6304399; Email:
Influence of maternal nutrition status during pregnancy on developmental outcome in first 30 days of independent neonatal life

Introduction: Birth weight is an important determinant of infant mortality. Two third of all deaths occurring in first twenty eight days of life happen due to low birth weight. LBW infants suffer higher risk of health complications at adult life. Maternal nutrition maybe the major intrauterine environmental, non-genetic, controllable factor which influences the growth of the fetus. Aim: To evaluate the influence of maternal nutritional status on developmental achievement of neonates in the first thirty days of independent life. Objective: 1. To study the nutritional status of mothers during pregnancy. 2. To evaluate birth weight, 5 min Apgar score, developmental outcome of newborn. 3. To correlate birth weight with health and developmental achievement of neonates in the first 30 days of independent life. Materials and Method: 121 mother-neonate pairs formed study population. Serum total protein, Albumin and Hemoglobin were evaluated for mother’s nutritional status. Gestational age, Birth weight, APGAR score and Cord blood Albumin were analyzed for neonates. The overall developmental outcomes were observed for the first 30 days of neonatal life. Results: Mean Birth weight of neonates was in the acceptable range, 39.67% LBW was observed at our hospital. LBW frequency was higher among female infants and small for gestational age. 5min Apgar score was good among ABW, but poor among LBW infants. LBW deliveries were high among mothers having poor nutritional status. LBW babies had low cord albumin levels & had higher frequency of health related problems. Overall developmental growth was poor amongst LBW, low cord albumin level and infants having a low Apgar score. Conclusion: Nutritional status of the mother during pregnancy influences the health and overall development of the newborn observed during first 30days of independent life. Promotion of optimal nutrition may ensure optimal fetal development and reduces the risk of chronic diseases in adulthood.
Surgical management of perilunate dislocations

The purpose of this review was to describe the kinematics of the wrist including a detailed anatomical description of the intrinsic and extrinsic carpal ligamentous supports, carpal instability, the mechanism of injury of perilunate dislocations and surgical treatment options. The surgical treatment options discussed included closed reduction and pinning and open treatment plus or minus ligamentous repair. For open treatment the arguments for and against a dorsal approach, volar approach and a combined approach are all discussed. It is now universally accepted that early surgical intervention gives the best results however the most efficacious approach remains debatable. It does appear however, that the volar only approach with an associated ligamentous repair is gaining acceptance as the most optimal approach.
Nuerobehavioural Investigation of The Role/S of Moringa Oleifera On 3-Nitropropionic Acid Model of Huntington’s Disease

Background: Huntington’s disease (HD) is a neurodegenerative disorder characterized by motor impairment that contribute to the death of striatial neurons and psychiatric symptoms. Systemic administration of 3-Nitropropionic Acid (3-NP) cause selective striatial degeneration similar to that seen in HD. Recent studies clearly demonstrate that increase oxidative stress is one of the major deleterious even in the 3-NP-induced neurodegenerative process. Moringa oleifera (MO) has been studied for the anti-oxidant, anti-inflammatory properties. This study evaluated the Neurobehavioral role of MO following 3-NP model of Huntington's disease. Methodology: Thirty-two adult mice weighting between 25-32g were used and divided into four groups (A, B, C and D), Group A serves as the control (Received food and ad libitum), B (Received MO+3-NP), C (Received only 3-NP) and D (Received 3-NP + MO) 3-Nitropropionic Acid (20mg/kg for 7 days) were induced intraperitoneal to the animals. MO were administer orally (250mg/kg) for a period of 7 days. Weights of the animals were checked periodically using the Acucuscope weighing Balance. Neurobehavioral assessment was carried out after administration. Animals were sacrificed at the end of the experiment NeurotransmittersDopamine and Glutamate were assayed in tissue homogenates and the levels were quantified. Results showed increased tissue levels of glutamate and dopamine and impaired neurobehavioural parameters in the Huntington's group, while the preventive group showed some degree of preservation of the normal parameters. Conclusion: 3-Np induced huntington's disease model in mice as expected with the characteristics of increased tissue levels of glutamate and dopamine and impaired behavioural and locomotive indices.
Efficacy of Prophylactic Oral Levofloxacin to Prevent Infection during Intensive Chemotherapy of Haematological Malignancy in Children

Patients undergoing cytotoxic chemotherapy for hematologic malignancy are at high risk for drug induced myelosuppression leading to neutropenia, which increases the susceptibility to infection, subsequent morbidity and mortality. Febrile neutropenia, with its potential to cause death, remains the most important dose limiting toxicity of anti-cancer treatment, influencing the quality of life and the clinical outcomes. A number of different antibiotic prophylaxis has been tried over several decades in order to prevent the chemotherapy related infections, but most of these studies were done in adults, and very few in children. This study was carried out in children to see the efficacy of prophylactic oral levofloxacin in reducing the bacterial infection which occurs during the cycles of intensive chemotherapy given to bring down the hematologic malignancy into remission.
PITX2 upregulation increases the risk of chronic atrial fibrillation in a dose-dependent manner by modulating IKs and ICaL—insights from human atrial modelling

Background Functional analysis has shown that the paired-like homeodomain transcription factor 2 (PITX2) overexpression associated with atrial fibrillation (AF) leads to the slow delayed rectifier K+ current (IKs) increase and the L-type Ca2+ current (ICaL) reduction observed in isolated right atrial myocytes from chronic AF (CAF) patients. Through multiscale computational models, this study aimed to investigate the functional impact of the PITX2 overexpression on atrial electrical activity. Methods The well-known Courtemanche-Ramirez-Nattel (CRN) model of human atrial action potentials (APs) was updated to incorporate experimental data on alterations in IKs and ICaL due to the PITX2 overexpression. These cell models for sinus rhythm (SR) and CAF were then incorporated into homogeneous multicellular one-dimensional (1D), two-dimensional (2D), and three-dimensional (3D) tissue models. The proarrhythmic effects of the PITX2 overexpression were quantified with ion current profiles, AP morphology, AP duration (APD) restitution, conduction velocity restitution (CVR), wavelength (WL), vulnerable window (VW) for unidirectional conduction block, and minimal substrate size required to induce re-entry. Dynamic behaviors of spiral waves were characterized by measuring lifespan (LS), tip patterns and dominant frequencies. Results The IKs increase and the ICaL decrease arising from the PITX2 overexpression abbreviated APD and flattened APD restitution (APDR) curves in single cells. It reduced WL and increased CV at high excitation rates at the 1D tissue level. Although it had no effects on VW for initiating spiral waves, it decreased the minimal substrate size necessary to sustain re-entry. It also stabilized and accelerated spiral waves in 2D and 3D tissue models. Conclusions Electrical remodeling (IKs and ICaL) due to the PITX2 overexpression increases susceptibility to AF due to increased tissue vulnerability, abbreviated APD, shortened WL and altered CV, which, in combination, facilitate initiation and maintenance of spiral waves.
Oral health knowledge, attitude and practice (KAP) among prison inmates of Ambala District, Haryana (India)

Aim: The study was to assess the oral health knowledge, attitude and practice among prison inmates of Ambala district (Haryana) India. Materials and method: It was a cross sectional study conducted on 570 prisoners after meeting the eligibility criteria. A 23 item closed ended structured questionnaire was used to assess the oral health related knowledge, attitude and practice among prison inmates. Results: the results show that oral health knowledge was poor among prisoner as 51% of the subjects did not know about the meaning of gum bleeding and 83% of subjects have no knowledge of dental plaque. Knowledge about injurious effects tobacco was better. Prisoner shows their negative attitude towards dental treatment as 45.6% of the subjects think, it is necessary to visit a dentist and 62.24% of the subjects had never visit to a dental clinic even before imprisonment. 38.66% of the subjects had their last visit for more than five year ago. Tooth extraction (27.4%) was the most common cause of last visit. Practice among prisoner reveals, 58% of the subjects do brush their teeth at least once a day and most of the subjects 90% use toothbrush and paste for cleaning their teeth. Most of the subjects (79%) brush their teeth in morning and 59% perform brushing for more than 2 minute. Conclusion: Oral health education should be imparted to the prisoner time to time and De-addiction clinics or programs should be establish in the prisons.
Multi-parametric 3-Tesla MRI evaluation of prostate in cases with negative prostatic biopsy with raised PSA levels-A tertiary care hospital study

The incidence of prostate cancer has been gradually increasing in the world. Checking the serum prostate-specific antigen (PSA) level and a digital rectal examination (DRE) are the gold standards for prostate cancer screening. Prostate gland is divided into four zones, the peripheral zone (PZ), transitional zone and central zone and anterior nonglandular fibromuscular stroma. Prostate is divided into minimum 16 and optionally 27 regions of interest as per European consensus meeting. Until recently, most professionals have been skeptical that magnetic resonance imaging (MRI) could be used on a widespread basis to diagnose or stage prostate cancer with any degree of reliability, and therefore help with making treatment decisions. The aim of the present study was to study diagnostic value of mpMRI of prostate in cases of raised PSA but with negative biopsy. The present study was carried out in the post graduate department of Radiodiagnosis and imaging Govt. Medical College Srinagar over a period of one year from May 2016 to April 2017. All patients with negative prostatic biopsy were evaluated on Siemens 3 tesla MRI scanner. All patients underwent initial T1W scanning to look for any evidence of hemorrhage and patients having hemorrhage due to previous biopsy were also excluded from study or their study was deferred until hemorrhagic artifacts disappear. After proper case selection patients were subjected to detail Multiparametric MRI (mpMRI) for prostate 6-8 weeks period was given from previous biopsy time to MRI study and cases with hemorrhage on T1 weighted sequence were either excluded from study or their study was deferred till resolution of Aijaz Ahmad Hakeem, Irshad Mohiuddin, Tanvir Iqbal. Multi-parametric 3-Tesla MRI evaluation of prostate in cases with negative prostatic biopsy with raised PSA levels A tertiary care hospital study. IAIM, 2018; 5(6): 5-13. Page 6 haemorrhage. The conclusion of the present study was that Mp-MRI prior to repeat biopsies can improve the detection rate of clinically significant PCa and allow for a more accuracy in prostate disease diagnosis.