Miracle-dz/UniFAR-FTUs huggingface dataset:
Light-controlled elimination of PD-L1+ cells

The programmed death ligand-1 (PD-L1), also known as CD274 or B7-H1, is mainly expressed on cancer cells and/or immunosuppressive cells in the tumor microenvironment (TME) and plays an essential role in tumor progression and immune escape. Immune checkpoint inhibitors (ICIs) of the PD-1/PD-L1 axis have shown impressive clinical success, however, the majority of the patients do not respond to immune checkpoint therapy (ICT). Thus, to overcome ICT resistance there is a high need for potent and novel strategies that simultaneously target both tumor cells and immunosuppressive cells in the TME. In this study, we show that the intracellular light-controlled drug delivery method photochemical internalization (PCI) induce specific and strongly enhanced cytotoxic effects of the PD-L1-targeting immunotoxin, anti-PD-L1-saporin (Anti-PDL1-SAP), in the PD-L1+ triple-negative breast cancer MDA-MB-231 cell line, while no enhanced efficacy was obtained in the PD-L1 negative control cell line MDA-MB-453. Using fluorescence microscopy, we reveal that the anti-PD-L1 antibody binds to PD-L1 on the surface of the MDA-MD-231 cells and overnight accumulates in late endosomes and lysosomes where it co-localizes with the PCI photosensitizer fimaporfin (TPCS2a). Moreover, light-controlled endosomal/lysosomal escape of the anti-PD-L1 antibody and fimaporfin into the cytosol was obtained. We also confirm that the breast MDA-MB-468 and the prostate PC-3 and DU-145 cancer cell lines have subpopulations with PD-L1 expression. In addition, we show that interferon-gamma strongly induce PD-L1 expression in the per se PD-L1 negative CT26.WT cells and enhance the PD-L1 expression in MC-38 cells, of which both are murine colon cancer cell lines. In conclusion, our work provides an in vitro proof-of-concept of PCI-enhanced targeting and eradication of PD-L1 positive immunosuppressive cells. This light-controlled combinatorial strategy has a potential to advance cancer immunotherapy and should be explored in preclinical studies.
Determinant Factors Poverty of Relativity in Banten Province: A Panel Data Analysis

The problem of the poverty of relativity today is still a crucial topic considering the economic conditions in Indonesia are experiencing a slump due to Covid-19. The problem of poverty relativity is one of the main points that must be faced by the government in providing social protection assistance policies as a form of economic recovery during the Covid-19. The poverty of relativity in Banten Province is relatively high even though it has been ranked 10 nationally. Therefore, this study aims to analyze the relationship between unemployment, income inequality, and human capital as well as find out which level is very dominant in the long run on each of the variables that directly affect the relativity of poverty in Banten Province. This study examines how changes in economic indicators occur due to the Covid-19 pandemic in 8 Regencies/Cities of Banten Province. The analysis of this study uses panel data regression using the method Fixed Effect Model (FEM) in 8 regencies/cities in Banten Province in the data range from 2016 to 2020. The results of this study indicate that unemployment due to layoffs has a positive and significant influence on the relativity of poverty in 8 districts/cities of Banten Province. Furthermore, this study shows that income inequality has no significant and positive effect on the relativity of poverty. Meanwhile, human capital appears to be one of the dominant factors that can have a negative and significant impact on economic recovery and reduce the relative impact of poverty during the Covid-19 pandemic.
Co-occurrence and Co-infection of COVID-19 and dengue: A serious public health issue

The prevailing COVID-19 pandemic has created havoc all around the world taking the lives of more than one million people. While the entire world is struggling hard to combat this pandemic; unfortunately, the burden has been further intensified by another fatal mosquito vector borne disease-dengue, particularly in dengue-endemic nations. The shared clinical features like fever, aches, respiratory ailments and so on by both the viral disease has led to the difficulty in their diagnosis and also to distinguish one from the other. In this regard, cases of misdiagnosis due to false positive test result has also been reported in some places. Hence the co-occurrence and co-infection of COVID-19 and dengue is indeed a great threat to public health in dengue endemic nations. This article aims to provide an overview of epidemiology, transmission and shared clinical features of COVID-19 and dengue besides highlighting the issue of misdiagnosis of both under clinical setting. Scientific evidence proving the fact that mosquitoes do not transmit SARS-CoV-2 pathogen has also been discussed. The present scenario of dengue outbreak in India amidst the prevailing COVID-19 pandemic has also been highlighted.
In Vitro Antifungal Screening of UPL-Pn-2 Peanut Seeds (Arachis hypogaea L.) Against Dandruff-Causing fungus, Malassezia globosa

This study aimed to screen the UPL-Pn-2 peanut seed extract for antifungal efficacy against dandruff-causing fungus, Malassezia globosa. Quantitative approach was conducted via in vitro antifungal screening through Kirby-Bauer test with experimental and control groups. Experimental group has 3 set-ups of peanut seed extracts in varying concentrations (25%, 50% and 100%). For control group, 3 set-ups of commercialized tech grade boric acid were also prepared in different concentrations (25%, 50%, 100%). Discs with dried methanol were used for negative control set-up. ANOVA revealed that antifungal effectiveness of peanut seed extract varied with the concentrations, while t-test showed no significant difference between peanut extract vis-à-vis boric acid concentrations. Also, pure boric acid and peanut extract were more effective compared to lower concentrations. The screening revealed antifungal efficacy of UPL-Pn-2 peanut seeds against dandruff-causing fungus, Malassezia globosa, which shows promising results as organic alternative to commercialized antidandruff products.
Recent advances in supercontinuum generation in specialty optical fibers [Invited]

Recent advances in supercontinuum generation in specialty optical fibers [Invited] T. Sylvestre,1,* E. Genier,1,2 A. N. Ghosh,1,3 P. Bowen,4 G. Genty,5 J. Troles,6 A. Mussot,2 A. C. Peacock,3 M. Klimczak,7 A. M. Heidt,8 J. C. Travers,9 O. Bang,4,10 AND J. M. Dudley1 Institut FEMTO-ST, UMR6174CNRS-Université Bourgogne Franche-Comté, 25030 Besançon, France Université de Lille, CNRS, UMR8523-PhLAM-Physique des Lasers Atomes etMolécules, F-59000 Lille, France Optoelectronics Research Centre, University of Southampton, Southampton, SO17 1BJ, UK NKTPhotonics A/S, Blokken 84, DK-3460, Birkerød, Denmark Photonics Laboratory, Tampere University, FI-33104 Tampere, Finland Université de Rennes, CNRS, ISCR-UMR6226, 35000 Rennes, France Faculty of Physics, University ofWarsaw, Pasteura 5, 02-093Warsaw, Poland Institute of Applied Physics, University of Bern, Bern, Switzerland School of Engineering and Physical Sciences, Heriot-Watt University, Edinburgh, EH14 4AS, UK DTUFotonik, Department of Photonics Engineering, Technical University of Denmark, 2800 Kgs. Lyngby, Denmark *Corresponding author: thibaut.sylvestre@univ-fcomte.fr
Investigating the Impact of Internal Communication and Organizational Structure on Employees’ Communication Satisfaction within Moroccan Higher Education Institutions

The study investigates the type of relationship that exists between internal organizational communication and internal organizational structure and the potential effect they might have on the employees’ level of organizational communication satisfaction in two Moroccan institutions of higher education. A mixedmethod case study design is used for the collection, the analysis, and the interpretation of data with concurrent triangulation methodology as a research strategy. The findings indicate that there is a strong negative relationship between internal organizational communication and internal organizational structure. The majority of the respondents are satisfied with communication within the case organizations and use a mixture of formal and informal internal organizational communication as well as an ambidextrous internal organizational structure. The results also show that there are also statistical differences among the employees’ level of organizational communication satisfaction.
Antecedents of continued usage intentions of web-based learning management system in Tanzania

Purpose – The purpose of this paper is to examine factors that predict students’ continued usage intention of web-based learning management systems (LMS) in Tanzania, with a specific focus on the School of Business of Mzumbe University. Specifically, the study investigated major predictors of actual usage and continued usage intentions of e-learning system, and challenges of using the e-learning system. Design/methodology/approach – Data were collected through a questionnaire survey of 300 third year undergraduate students, with a rate of return of 77 per cent. A total of 20 faculty members were also interviewed. The unified theory of acceptance and use of technology (UTAUT) was utilized in the study. Findings – The results show that actual usage was determined by self-efficacy, while continued usage intentions of web-based learning system was predicted by performance expectancy, effort expectancy, social influence, self-efficacy, and actual usage. Challenges for using web-based LMS were related to inform.
Do antiepileptic drugs cause premature atherosclerosis by disturbing lipid metabolism?

Neslihan Eskut1, Cagla Soysuren2, Gulec Mert Dogan3, Gamze Tuna4, Feriha Toksoz5, Nazif Calıs6, Mustafa Cetiner7, Yasar Zorlu8, Guldal Kirkali9 1 Department of Neurology, University of Health Sciences, Izmir Bozyaka Education and Training Hospital, Izmir 2 Department of Neurology, Menemen State Hospital, Izmir 3 Department of Pediatric Radiology, Inonu University, Malatya Educational and Research Hospital, Malatya 4 Department of Moleculer Medicine, Dokuz Eylul University, Institute of Health Sciences, Izmir 5 Department of SACEM Life Tecnologies, Dokuz Eylul University, Technology Development Zone (DEPARK), Izmir 6 Iskenderun Technical University, Faculty of Business and Management Sciences, Hatay 7 Department of Neurology, Kutahya Health Sciences University, Kutahya 8 Department of Neurology, University of Health Sciences, Izmir Tepecik Education and Training Hospital, Izmir 9 Department Biochemistry, Dokuz Eylul University, Faculty of Medicine, Izmir, Turkey Evaluation of premature atherosclerosis in patients with epilepsy Do antiepileptic drugs cause premature atherosclerosis by disturbing lipid metabolism?
Assessment of palliative approach in the pain management in endodontic emergencies during Covid-19 outbreak: Retrospective cohort study

Aim: During the coronavirus disease, a palliative approach was recommended for the management of endodontic emergencies. This retrospective cohort study was conducted to investigate the effectiveness of dexamethasone or ibuprofen-acetaminophen combination for pain management in endodontic emergencies. Material and Methods: One hundred and eight records of patients who presented to the emergency department with dental pain were evaluated retrospectively. Since interventional procedures were not performed during the pandemic period, Specific analgesics/antibiotics for the management of pain were preferred. A follow-up protocol with a questionnaire was developed to observe the effectiveness of palliative treatment and make changes if necessary. All participants received a questionnaire to rate the pain levels 6, 12, 18, 24, 48, and 72 hours after taking the drug. All data were collected from the patient file and assessed. After inclusion and exclusion criteria, 32 patients were included (n = 19, ibuprofen + acetaminophen;n = 13, dexamethasone). Data were analyzed using the chi-square test (P = 0.05). Results: In both groups, a significant decrease in pain was experienced immediately after medication and at 6, 12, and 18 hours, with no significant difference (P > .05). However, dexamethasone (Group II) resulted in lower pain levels than ibuprofen\acetaminophen (Group I) at 24 and 48 hours (P < .05) Discussion: Both dexamethasone and ibuprofen-acetaminophen can be good palliative choices in endodontic emergencies in pandemic conditions. However, at 24 and 48 hours, dexamethasone resulted in lower pain levels.
On supercompactness of $\omega_1$

This paper studies structural consequences of supercompactness of $\omega_1$ under $\sf{ZF}$. We show that the Axiom of Dependent Choice $(\sf{DC})$ follows from "$\omega_1$ is supercompact". "$\omega_1$ is supercompact" also implies that $\sf{AD}^+$, a strengthening of the Axiom of Determinacy $(\sf{AD})$, is equivalent to $\sf{AD}_\mathbb{R}$. It is shown that "$\omega_1$ is supercompact" does not imply $\sf{AD}$. The most one can hope for is Suslin co-Suslin determinacy. We show that this follows from "$\omega_1$ is supercompact" and Hod Pair Capturing $(\sf{HPC})$, an inner-model theoretic hypothesis that imposes certain smallness conditions on the universe of sets. "$\omega_1$ is supercompact" on its own implies that every Suslin co-Suslin set is the projection of a determined (in fact, homogenously Suslin) set. "$\omega_1$ is supercompact" also implies all sets in the Chang model have all the usual regularity properties, like Lebesgue measurability and the Baire property.
A quantitative analysis to evaluate the role of serum total and lipid bound sialic acid level as diagnostic markers in oral potentially malignant condition and oral squamous cell carcinoma

Oral cancer is the sixth most common cancer throughout the world and is a crucial issue in regions where tobacco habits, in the form of chewing and/or smoking, with or without alcohol intake, are common. Squamous cell carcinoma is the cause for 95% of oral cancers and is associated with avoidable aetiological risk factors. The most successful means to enhance the survival and reduce morbidity, damage, duration of treatment and hospital cost is the detection of oral cancer at an early stage. It is essential to study marker levels in patients with oral precancer who are at a high risk of developing oral cancer. The present study was carried out to evaluate usefulness of serum Total Sialic Acid (TSA) and serum Lipid-Bound Sialic Acid (LSA) as markers of oral submucous fibrosis and oral cancer. Study consisted of 60 patients and 30 controls. There were 3 study groups, Group I control, Group II OSMF, and Group III oral cancer consisting of 30 patients each. Serum of all the patients in the control group and study groups were collected and stored at -20 o C until analyzed. Levels of serum TSA and LSA were estimated spectrophotometrically. The results also demonstrated that the assessment of TSA and LSA by simple, in-expensive and reproducible methods can provide significant clinical information about the extent of malignant disease and can differentiate between patients with oral precancer and oral cancer. Keyword:Oral cancer, TSA, LSA, oral submucous fibrosis
A Systematic Review of the Causes Diagnosis and Treatment of Early Childhood Dental Caries

The current study sought to systematically review the existing literature to identify the risk factors, diagnosis, and treatment aspects of early childhood dental caries. A critical literature search was performed to screen and capture those relevant to the topic of study. The methodology used in this study was a systematic design that involved screening 1576 articles from PubMed and Google scholar. Data relating to the study design, setting, definition of outcomes measure, the source population's inclusion and exclusion criteria, and the methodological design quality using the Newcastle Ottawa Scale. Among the identified studies, 1238 articles were excluded based on the limitations and risk factors of early childhood dental caries. Examining reports base on the treatment of dental caries identified 56 studies. Further screening of the references of the identified studies identified three studies that addressed early childhood dental caries. Additional screening of the articles found only 12 articles that discussed three more pieces from the screening reference lists of the identified themes. Data collected from the current study were analyzed using the arithmetic percentage analysis with charts and graphs. The survey results show that cariogenic microorganisms, diet and environmental factors are the significant risk factors for childhood dental caries. The study concludes that pediatric dentists should build a common consensus on encouraging.
Technical efficiency of Islamic and conventional banks: Evidence from the stochastic meta-frontier directional distance function approach

We employ the stochastic meta-frontier directional distance function (SMF-DDF) approach to examine technical inefficiency of Islamic and conventional banks in 28 countries with specific attention to the role of Shariah supervisory board (SSB)—an additional layer of governance in Islamic banks. Islamic banks have lower group-specific inefficiency but higher metainefficiency compared to their conventional counterparts, which is driven by Islamic banks’ failure to adopt the best available banking technology. The SSB is found to be conducive in reducing technical inefficiency of Islamic banks.
Reliability of Pulse Rate Variability in Elderly Men and Women: an Application of Cross-Mapping Approach

Photoplethysmography (PPG) is a completely noninvasive, optical method of assessing blood flow dynamics in peripheral vasculature. Wearable devices for PPG recording are becoming increasingly popular, due to their cost-effectiveness and ease of use. For these reasons, many recent scientific studies have proposed the use of pulse rate variability (PRV) extracted from PPG as a surrogate for heart rate variability (HRV), in monitoring autonomic activity and cardiovascular health.In this work, we used a cross-mapping approach, a methodology based on chaos theory, to compare PRV and HRV dynamics, and investigate their agreement according to age and gender of healthy subjects. We used ECG and PPG data acquired from 57 subjects (41 young and 16 elderly) during resting state in the supine position. Signals were gathered from the publicly available VORTAL dataset. Our results showed a statistically significant decrease of PRV reliability as an HRV surrogate in old participants, which was confirmed as significant when only men subjects were analyzed (p-value<0.01). Our findings, although preliminary, suggest greater caution in the use of PPG devices for monitoring cardiovascular health, especially in elderly men.
STUDY OF FETAL DOPPLER INDICES AND AMNIOTIC FLUID INDEX IN GROWTHLY-RESTRICTED FETUSES

Aim of the study: To evaluate the association between the renal artery (RA) and middle cerebral artery (MCA) resistance indices (RI) and amniotic fluid index as predictors of growthly restricted fetuses and their impact on fetal outcome. Type of the study: Prospective descriptive analytical study. Setting: Department of Obstetrics and Gynecology Menof General Hospital-Egyptian Ministry of Health and Menoufia University Hospital-Menoufia University, Egypt. Methods: Over almost 1.5 years, examination of a total 40 pregnant women between 3438 weeks of gestation. Women were divided into 2 groups; women with normal pregnancy (group I, n=20) and women with IUGR pregnancy (group II, n=20) were recruited and underwent ultrasonography (U/S) for amniotic fluid index (AFI) which was measured using four quadrants technique, and Doppler resistance indices of fetal renal artery (FRA) and middle cerebral artery (MCA), All data collected and correlated to see their impact on fetal outcome. Results: The Doppler index and the artery with highest coefficient were the fetal renal artery and its resistance index. The coefficient for this Doppler index was -0.78. In other word the resistance index of fetal renal artery has the maximum predictive as well as diagnostic value for intrauterine growth restriction. Accordingly the FRA RI had Cut off point 0.96, MCA RI had Cut off point 0.72, In the present study, Both FRA RI and MCA RI were equally sensitive (sensitivity 90%), and AFI had comparably low sensitivity (sensitivity 80%) in predicting adverse outcomes (5 minutes Apgar score < 7, death, meconium aspiration, admission to ICU). FRA RI was more specific (specificity 100%) (PPV 100%) than either MCA RI (specificity 95%) (PPV 94.7%) or AFI (specificity 85%) (PPV 84.2%) alone in predicting any adverse out come. While negative predictive value of FRA RI was 90.9% when compared to 90.5% for MCA RI and 80.6% for AFI. Diagnostic accuracy of FRA RI (accuracy 95%) was better than MCA RI (accuracy 92.5%) and AFI (accuracy 82.5%) in predicting adverse outcomes. Conclusion: This study has shown that abnormal AFI, MCA RI and FRA RI in particular are a strong predictor of adverse perinatal outcome in IUGR. MCA RI is more useful than AFI in prediction IUGR outcome when considered individually. FRA RI was more specific than either MCA RI or AFI alone in predicting any adverse outcomes. Combined sonographic and Doppler parameters such as Low EFW and low AFI as well as low MCA RI and High FRA RI have better sensitive and predictive value for estimation the adverse outcome. Further studies and randomized controlled trials are needed.
New Applications that Come from Extending Seismic Networks into Buildings

This thesis describes engineering applications that come from extending seismic networks into building structures. The proposed applications will benefit the data from the newly developed crowd-sourced seismic networks which are composed of low-cost accelerometers. An overview of the Community Seismic Network and the earthquake detection method are addressed. In the structural array components of crowd-sourced seismic networks, there may be instances in which a single seismometer is the only data source that is available from a building. A simple prismatic Timoshenko beam model with soil-structure interaction (SSI) is developed to approximate mode shapes of buildings using natural frequency ratios. A closed form solution with complete vibration modes is derived. In addition, a new method to rapidly estimate total displacement response of a building based on limited observational data, in some cases from a single seismometer, is presented. The total response of a building is modeled by the combination of the initial vibrating motion due to an upward traveling wave, and the subsequent motion as the low-frequency resonant mode response. Furthermore, the expected shaking intensities in tall buildings will be significantly different from that on the ground during earthquakes. Examples are included to estimate the characteristics of shaking that can be expected in mid-rise to high-rise buildings. Development of engineering applications (e.g., human comfort prediction and automated elevator control) for earthquake early warning system using probabilistic framework and statistical learning technique is addressed.