Miracle-dz/UniFAR-FTUs huggingface dataset:
Who sells to whom in the suburbs? Home price inflation and the dynamics of sellers and buyers in the metropolitan region of Paris, 1996–2012

Price inflation has outbalanced the income of residents and buyers in major post-industrial city-regions, and real estate has become an important driver of these inequalities. In a context of a resilient inflation of home values during the last two decades in the greater Paris Region, it is critical to examine housing price dynamics to get a better understanding of socioeconomic segregation. This paper aims at presenting spatial analysis of the dynamics of segregation pertaining to inflation, analyzing price and sellers and buyers data. Using interpolation techniques and multivariate analysis, the paper presents a spatial analysis of property-level data from the Paris Chamber of Notaries (1996-2012) in a GIS (159,000 transactions in suburban areas, single family homes only). Multivariate analysis capture price change and local trajectories of occupational status, i.e. changes in balance between inward and outward flows of sellers and buyers. We adopt a method that fits the fragmented spatial patterns of suburbanization. To do so, we remove the spatial bias by means of a regular 1-km spatial grid, interpolating the variables within it, using a time-distance matrix. The main results are threefold. We document the spatial patterns of professionalization (a rise of executives, intermediate occupation and employees) to describe the main trends of inward mobility in property ownership in suburbs, offsetting the outward mobility of retired persons. Second, neighborhood trajectories are related the diverging patterns of appreciation, between local contexts of accumulation with a growth of residential prices, and suburbs with declining trends. The maturity of suburbanization yields a diversified structure of segregation between the social groups, that do not simply oppose executives vs. blue collar suburbs. A follow-up research agenda is finally outlined.
Requirement for YAP1 signaling in myxoid liposarcoma

Myxoid liposarcomas (MLS), malignant tumors of adipocyte origin, are driven by the FUS‐DDIT3 fusion gene encoding an aberrant transcription factor. The mechanisms whereby FUS‐DDIT3 mediates sarcomagenesis are incompletely understood, and strategies to selectively target MLS cells remain elusive. Here we show, using an unbiased functional genomic approach, that FUS‐DDIT3‐expressing mesenchymal stem cells and MLS cell lines are dependent on YAP1, a transcriptional co‐activator and central effector of the Hippo pathway involved in tissue growth and tumorigenesis, and that increased YAP1 activity is a hallmark of human MLS. Mechanistically, FUS‐DDIT3 promotes YAP1 expression, nuclear localization, and transcriptional activity and physically associates with YAP1 in the nucleus of MLS cells. Pharmacologic inhibition of YAP1 activity impairs the growth of MLS cells in vitro and in vivo. These findings identify overactive YAP1 signaling as unifying feature of MLS development that could represent a novel target for therapeutic intervention.
Nutritional Characteristics of Four Underutilized Edible Wild Fruits of Dietary Interest in Ghana

Malnutrition has been a serious issue in Ghana and Africa as a whole. However, the potential of many indigenous fruits to combat it has not yet been tested. Therefore, this study aimed to determine the nutritional characteristics of four underutilized wild fruits (Gardenia erubescens, Sclerocarya birrea, Diospyros mespiliformis, and Balanites aegyptiaca) of dietary interest in Ghana. The nutritional and antinutritional characteristics of the fruits were analyzed according to standard methods (laid down by the Association of Official Analytical Chemists and other well-known researchers) on a dry weight (dw) basis. The nutritional value of the fruits was high enough to contribute to the nutrient requirements of humans, with their iron (0.34–1.46 mg/100 g), zinc (0.81–2.97 mg/100 g), vitamin A (0.84–2.03 mg/100 g), and β-carotene (64.84–176.89 mg/100 g) contents worth special mention. The antinutrient content also ranged between 0.06–1.82 mg/g. Therefore, it is evident from the study that the fruits, although containing some levels of antinutrients, are nutrient-dense, suggesting their potency in fighting malnutrition in humans.
Impact of jasmonic acid on lignification in the hemp hypocotyl

ABSTRACT Phytohormones are crucial molecules regulating plant development and responses to environmental challenges, including abiotic stresses, microbial and insect attacks. Most notably, phytohormones play important roles in the biosynthesis of lignocellulosics. Jasmonates are involved in secondary growth and secondary metabolism, such as phenylpropanoids and lignin biosyntheses. At the physiological and molecular levels, the actions of phytohormones depend on subtle concentration changes, as well as antagonistic equilibria between two or more of these molecules. In this article, we investigate the consequences of jasmonic acid (JA) spraying on young hemp hypocotyls. First, we show that JA application results in changes in the monomeric composition of lignin. Second, we highlight that, five days after application, JA leads to an increase in salicylic acid (SA) content in hemp hypocotyls. These results are discussed in the light of the known antagonism between JA and SA at both the physiological and molecular levels.
Space Trumps Time When Talking About Objects

Abstract The nature of the relationship between the concepts of space and time in the human mind is much debated. Some claim that space is primary and that it structures time (cf. Lakoff & Johnson, 1980) while others (cf. Walsh, 2003) maintain no difference in status between them. Using fully immersive virtual reality (VR), we examined the influence of object distance and time of appearance on choice of demonstratives (this and that) to refer to objects. Critically, demonstratives can be used spatially (this/that red triangle) and temporally (this/that month). Experiment 1 showed a pattern of demonstrative usage in VR that is consistent with results found in real‐world studies. Experiments 2, 3, and 4 manipulated both when and where objects appeared, providing scenarios where participants were free to use demonstratives in either a temporal or spatial sense. Although we find evidence for time of presentation affecting object mention, the experiments found that demonstrative choice was affected only by distance. These results support the view that spatial uses of demonstratives are privileged over temporal uses.
Clinical significance of β-catenin, hTERT, p53, and Wnt7A as biomarkers for ovarian cancer

Ovarian cancer is the fifth leading overall cause of death from cancer in women and the most common cause of gynaecologic mortality according to WHO cancer statistics, 2015. Approximately 75% of women with ovarian carcinoma present with Stage III or IV disease as early diagnosis is frequently difficult because of vague abdominal symptoms at presentation (abdominal pain, bloating, gastrointestinal or urinary tract complaints). In India, the North East (NE) region is seeing a marked increase in cancer incidence and deaths. The NE tribes and the genome pool of the region are quite distinct from the rest of India. The potential risk factors may be due to the diversity in genome pool, food habits, genetic susceptibility or role of some other factor associated with it. The age adjusted incidence rate (AAR) of ovarian cancer in NE India ranged from 1.5 to 10.7 per one Lakh populations according to the National Cancer Registry Programme, 2013. The World Health Organization (WHO) classifies ovarian neoplasms according to their histological differentiation, namely epithelial, sex cord-stromal, and germ cell neoplasms [1]. Epithelial ovarian cancer (EOC) represent the largest group and are basically subdivided into serous, mucinous, endometrioid, clear cell, and transitional cell tumors [1]. β-catenin, encoded by β-catenin gene (CTNNB1), is a component of the Wnt signalling pathway and plays a welldefined role in cellular adhesion [2]. Wnts are secreted glycoproteins that bind to the members of the seven transmembrane family of proteins called Frizzleds (Fzds) [3]. The levels of β-catenin are regulated by a protein complex that promotes its degradation by the ubiquitin–proteasome pathway via glycogen synthase kinase-3β (GSK-3β) mediated phosphorylation of amino-terminal β-catenin sequences [4, 5]. When the Wnt pathway is activated, degradation of β-catenin is inhibited, resulting in accumulation of β-catenin, and transcriptional activation of target genes such as c-myc, cyclin D, matrix metalloproteinase-7 (MMP-7), and cyclooxygenase-2 [5]. The present study focused on WNT7A as it is exclusively expressed in epithelial cells in the female reproductive tract [6]. Furthermore, WNT7A increases cell proliferation via activation of the canonical WNT/β-catenin pathway [7]. Mutation and deregulation of the components of Wnt/βcatenin pathway in many human cancers are known to be the cause for tumorigenesis [4]. Human telomerase reverse transcriptase (hTERT) is an important factor during tumourigenesis and its level is elevated during an early stage of tumourigenesis [8]. In most normal human somatic cells telomerase is repressed, and without new synthesis of telomeres, with progressive cell division the chromosomes shorten, eventually triggering
Dietary changes during the Great Recession in Portugal: comparing the 2005/2006 and the 2014 health surveys

Abstract Objective We aimed at analysing changes in consumption of selected food groups in the Portuguese population before and after the Great Recession, which hit the country between 2008 and 2013. Design We used pooled cross-sectional data from the Portuguese National Health Interview Surveys of 2005/2006 and 2014. We modelled the probability of consumption of soup, fish, meat, potatoes/rice/pasta, bread, legumes, fruit, vegetables and sweets/desserts, as a function of the year, controlling for age, sex and education, using logistic regressions. Then, we stratified the analysis by age group and education level. Analyses were adjusted for survey weights. Setting Portugal (2005/2006 to 2014). Participants Adults (n 43273) aged 25–79 years. Results From 2005/2006 to 2014, there was a significantly lower consumption of fish, soup, fruit and vegetables. Conversely, the consumption of legumes and sweets/desserts was significantly higher in 2014. The changes in the selected food groups were consistent across most education levels. Among people aged 65 years or above, there were no significant changes in most foods, except an increase in the consumption of legumes and sweets/desserts. In contrast, people aged 25–39 and 40–64 years significantly decreased their intakes of fish and soup and increased their consumption of sweets/desserts. Conclusions The consistent results across education levels suggest that changes in dietary habits are not linked to the economic downturn. By contrast, our findings suggest a shift away from foods commonly linked to the Mediterranean diet, particularly among younger people.
Pyometra in Cats: Medical Versus Surgical Treatment

Pyometra is not a common disease in cats however in Egyptian veterinary clinics where owners do not usually go for elective neutering become a more common affection. It is an acute or chronic purulent endometritis, a sequel to progesterone stimulation. The traditional therapy for pyometra is ovariohysterectomy however medical treatment may be requested by owners or cat condition may not permit surgical treatment. The aim of the present study is to characterize the pyometra in cats and compare between ovariohysterectomy and medical treatment using PGF2α alone or PGF2α in combination with dopamine agonist. 45 cats were diagnosed with pyometra. Cats divided into 3 groups. Group 1 (n= 23): animals received PGF2α, Group 2 (n= 15): cats received PGF2α plus oral administration of Bromocriptine. Group 3 (n=7): went for ovariohysterectomy. Survival analysis of cats was performed in this study for 2 years after diagnosis. In G1 we censored 14 animals, eight of them returned with recurrent pyometra. The first recurrent case was recorded 3 months post-treatment. In G2 we censored 12 cats, four of them were returned with recurrent pyometra, the first recurrent case was met 8 months post-treatment. After 24 months, both G1 and G2 have no difference in the survival rate which reach for both treatment about 60% success in both groups. However, G3 survival rate was 100% success. Using dopamine agonist in medical treatment my delay the recurrences of pyometra for a short term however ovariohysterectomy whenever possible may be the best choice for treatment of pyometra.
Preexisting musculoskeletal burden and its development under letrozole treatment in early breast cancer patients

One of the most common adverse events (AEs) occurring during treatment with aromatase inhibitors (AIs) is musculoskeletal pain. The aim of our study was to analyze the influence of preexisting muscle/limb pain and joint pain on the development of AI‐induced musculoskeletal AEs. Women eligible for upfront adjuvant endocrine therapy with letrozole were included in the PreFace study, a multicenter phase IV trial. During the first treatment year, they were asked to record musculoskeletal AEs monthly by answering questions regarding pain symptoms and rating the pain intensity on a numeric rating scale from 0 (no pain) to 10 (very strong pain). Pain values were compared using nonparametric statistical tests. Overall, 1,416 patients were evaluable. The average pain value over all time points in women with preexisting muscle/limb pain was 4.3 (median 4.3); in those without preexisting pain, it was 2.0 (median 1.7). In patients without preexisting muscle/limb pain, pain levels increased relatively strongly within the first 6 months (mean increase +0.9, p < 0.00001) in comparison with those with preexisting pain (mean increase +0.3, p < 0.001), resulting in a statistically significant difference (p < 0.00001) between the two groups. The development of joint pain was similar in the two groups. Women without preexisting muscle/limb pain or joint pain have the greatest increase in pain after the start of adjuvant AI therapy. Women with preexisting pain have significantly higher pain values. The main increase in pain values takes place during the first 6 months of treatment.
The impact of instruction- and experience-based evaluative learning on IAT performance: a Quad model perspective

ABSTRACT Learning procedures such as mere exposure, evaluative conditioning, and approach/avoidance training have been used to establish evaluative responses as measured by the Implicit Association Test (IAT). In this paper, we used the Quad model to disentangle the processes driving IAT responses instantiated by these evaluative learning procedures. Half of the participants experienced one of these three procedures whereas the other half only received instructions about how the procedure would work. Across three experiments (total n = 4231), we examined the extent to which instruction-based versus experience-based evaluative learning impacted Quad estimates of the Activation of evaluative information in IAT responses. Relative to a control condition, both instruction- and experience-based evaluative learning procedures influenced Activation. Moreover, and contrary to what prevailing models of implicit evaluations would predict, in no instance did experience-based procedures influence (positive or negative) Activation more strongly than instruction-based procedures. This was true for analyses which combined procedures and also when testing all three procedures individually. Implications for the processes that mediate evaluative learning effects and the conditions under which those processes operate are discussed.
The Relationship of Religiosity and Marital Satisfaction: The Role of Religious Commitment and Practices on Marital Satisfaction Among Pakistani Respondents

The sociology of religion focuses on an individual’s social and married life. This research performed the first focalized examination of the influence of spirituality and religiosity on the marital satisfaction of Pakistani Muslim couples and how religious commitment and religious practice strengthens the relationship of married couples. This study incorporates the Kansas Marital Satisfaction scale (KMSS), the Religious Commitment Inventory (RCI-10) and the Religious Practice scale to measure marital satisfaction. Survey questionnaires, including a survey invitation letter and an informed consent form, were sent to married couples residing in five urban areas of Pakistan. The sample consisted of 508 valid responses, 254 males and 254 females, exploring the respondent’s perception of their marital satisfaction. The data received were screened and tested through SPSS version 25. The first step of the data analysis was to examine the impact of religiosity variables (religious commitment, religious practice) on marital satisfaction. Findings indicated that religious commitment and religious practice are vital for a happy married life. The findings help explain the social dynamics of marital satisfaction in Pakistani culture. The results also indicated that religious commitment and religious practice strengthened and promoted marital satisfaction. This study is novel in the context of Pakistani culture and conclusions cannot be generalized to the whole population. Other religious factors may provide further research directions. The results of this study may help practitioners and decision-makers focusing on marital satisfaction issues.
New insights into a spectrum of developmental malformations related to mTOR dysregulations: challenges and perspectives

In recent years the role of the mammalian target of rapamycin (mTOR) pathway has emerged as crucial for normal cortical development. Therefore, it is not surprising that aberrant activation of mTOR is associated with developmental malformations and epileptogenesis. A broad spectrum of malformations of cortical development, such as focal cortical dysplasia (FCD) and tuberous sclerosis complex (TSC), have been linked to either germline or somatic mutations in mTOR pathway‐related genes, commonly summarised under the umbrella term ‘mTORopathies’. However, there are still a number of unanswered questions regarding the involvement of mTOR in the pathophysiology of these abnormalities. Therefore, a monogenetic disease, such as TSC, can be more easily applied as a model to study the mechanisms of epileptogenesis and identify potential new targets of therapy. Developmental neuropathology and genetics demonstrate that FCD IIb and hemimegalencephaly are the same diseases. Constitutive activation of mTOR signalling represents a shared pathogenic mechanism in a group of developmental malformations that have histopathological and clinical features in common, such as epilepsy, autism and other comorbidities. We seek to understand the effect of mTOR dysregulation in a developing cortex with the propensity to generate seizures as well as the aftermath of the surrounding environment, including the white matter.
Early detection of electromechanical dysfunction in patients with idiopathic premature ventricular contractions

Premature ventricular contractions (PVCs) induced by subtle cardiac dysfunction are missed by echocardiography. We evaluated acoustic cardiography for detection of early electromechanical dysfunction in patients with idiopathic PVCs and normal left ventricular ejection fraction (LVEF), and investigated the impact of radiofrequency ablation (RFA) in reversing this adverse effect.
Triterpene Acid and Phenolics from Ancient Apples of Friuli Venezia Giulia as Nutraceutical Ingredients: LC-MS Study and In Vitro Activities

Triterpene acid and phenolic constituents from nine ancient varieties of apple (Malus domestica) fruits cultivated in Fanna, Friuli Venezia Giulia region, northeast Italy, were analyzed and compared with four commercial apples (‘Golden Delicious’, ‘Red Delicious’, ‘Granny Smith’ and ‘Royal Gala’). Total phenolic and flavonoid contents were measured by spectrophotometric assays. The quali-quantitative fingerprint of secondary metabolites including triterpene acid was obtained by LC-DAD-(ESI)-MS and LC-(APCI)-MS, respectively. Based on the two LC-MS datasets, multivariate analysis was used to compare the composition of ancient fruit varieties with those of four commercial apples. Significant differences related mainly to the pattern of triterpene acids were found. Pomolic, euscaphyc, maslinic and ursolic acids are the most abundant triterpene in ancient varieties pulps and peels, while ursolic and oleanolic acids were prevalent in the commercial fruits. Also, the content of the phenolic compounds phloretin-2-O-xyloglucoside and quercetin-3-O-arabinoside was greater in ancient apple varieties. The antioxidant (radical scavenging, reducing power, metal chelating and phosphomolybdenum assays) and enzyme inhibitory effects (against cholinesterase, tyrosinase, amylase and glucosidase) of the samples were investigated in vitro. Antioxidant assays showed that the peels were more active than pulps. However, all the samples exhibited similar enzyme inhibitory effects. Ancient Friuli Venezia Giulia apple cultivars can be a source of chlorogenic acid and various triterpene acids, which are known for their potential anti-inflammatory activity and beneficial effects on lipid and glucose metabolism. Our results make these ancient varieties suitable for the development of new nutraceutical ingredients.
PLASMABLASTIC MYELOMA: CASE REPORT

……………………. Plasmablastic myeloma is an atypical variant of multiple myeloma with a poor prognosis. We report a case of a 59-year-old-male, who was diagnosed to have plasmablastic myeloma. We emphasize the diagnostic difficulty of this type of myeloma and the therapeutic options.
Do Gender and Age of bank clients have an impact on Bank Card usage?

This paper attempts to investigate the ownership and usability of debit and credit cards in Kosovo focusing on two demographic variables: the gender and age of the bank's clients. For research purposes, the Central Bank of Kosovo (CBK) data are used for two consecutive years: 2015 and 2016. The comparative method is used to compare the clients’ behavior on the choice of the method to conduct payment and the usage of credit and debit cards in Kosovo banks for two consecutive years 2015 and 2016 based on the gender and age of bank clients. The results show that there is a gender gap, as debit and credit cards are owned and used more by males than females in all age groups and payment types. Whereas, for the variable age, the results show that both debit and credit cards are mostly used by customers aged 25-35 years followed by those 18-25 years. Based on the results of the paper, conclusions were drawn and some suggestions were given. We suggest that banks should do more to enhance the ownership and usage of debit and credit cards by females and elderly clients. Regarding the variable gender, we suggest that banks should offer credit and bonus cards with preferential rates to female entrepreneurs considering the very small number of female entrepreneurs to boost female entrepreneurship and decrease female unemployment in Kosovo.