Miracle-dz/UniFAR-FTUs huggingface dataset:
Mediating Effect of Supply Chain Capabilities on the Relationship of Data Driven Supply Chain Management and Business Performance: A Study of the Manufacturing Industry

Despite the data driven supply chain (DDSC) significance, the extant researches have a limited attention on how the DDSC effects to supply chain capabilities (SCC) to enhance the business performance (BP). Based on this gap, the main objective of the study is to investigate how DDSC effect to BP through the SCC in the manufacturing industries of the Indonesia. To achieve this objective, data has been collected from the 600 supply chain managers who were working in the food industry of Indonesia by using a simple random sampling technique which yield a 55% response rate. To analyze the results Smart PLS 3 software and structural equation modeling (SEM) was employed. The SEM findings has shown that in the direct effect DDSC has a significant and positive association with the BP, DDSC also have a significant and positive association with the SCC and SCC also has a positive and significant association with the BP. On the other hand, the indirect effect also shows that SCC is partially mediates in the relationship of DDSC and BP of the manufacturing industry of Indonesia. These findings show that SCC is considered to be a significant mediator in the relationship of DDSC and BP. Based on these findings, it could be considered that SCC is an important contribution which added a body of literature in the extant empirical studies. The findings of the current study could also be helped to supply chain managers to provide guideline to the supply chain mangers to know about the importance of the DDSC to increase the BP of the organization. The research limitations and future directions of the study also explained at the end of the study.
Analysis of the genomic architecture of a complex trait locus in hypertensive rat models links Tmem63c to kidney damage

Unraveling the genetic susceptibility of complex diseases such as chronic kidney disease remains challenging. Here, we used inbred rat models of kidney damage associated with elevated blood pressure for the comprehensive analysis of a major albuminuria susceptibility locus detected in these models. We characterized its genomic architecture by congenic substitution mapping, targeted next-generation sequencing, and compartment-specific RNA sequencing analysis in isolated glomeruli. This led to prioritization of transmembrane protein Tmem63c as a novel potential target. Tmem63c is differentially expressed in glomeruli of allele-specific rat models during onset of albuminuria. Patients with focal segmental glomerulosclerosis exhibited specific TMEM63C loss in podocytes. Functional analysis in zebrafish revealed a role for tmem63c in mediating the glomerular filtration barrier function. Our data demonstrate that integrative analysis of the genomic architecture of a complex trait locus is a powerful tool for identification of new targets such as Tmem63c for further translational investigation.
The Coronavirus Pandemic and Europe’s Undeclared Economy: Impacts and a Policy Proposal

Abstract The coronavirus pandemic has led to a loss of revenues for enterprises and workers due to workplace closures and restrictions on movement to ‘flatten the curve’. In response, governments have made available temporary financial support to enterprises and workers affected. This paper evaluates a group currently excluded from this support, namely enterprises and workers in the undeclared economy, and a possible government policy response. To identify those involved, a 2019 Eurobarometer survey of undeclared work in Europe is reported. This reveals that one in every 132 European citizens relies wholly on undeclared earnings and the sectors and population groups involved. Given their reduced revenues and inability to access the temporary financial support, a voluntary disclosure initiative is recommended which brings undeclared enterprises and workers into the declared economy and onto the radar of state authorities by offering access to this temporary financial support if they disclose their previous undeclared work.
Rapid micro-induction of buprenorphine/naloxone for opioid use disorder in an inpatient setting: A case series.

BACKGROUND AND OBJECTIVES Buprenorphine/naloxone has been shown to be effective in the treatment of opioid use disorder. Due to its pharmacological properties, induction can be challenging, time-consuming, and result in sudden onset of withdrawal symptoms. METHODS Retrospective case series (n = 2). RESULTS Two patients with opioid use disorder were successfully started on buprenorphine/naloxone using a rapid micro-induction technique that did not cause precipitated withdrawal or require preceding cessation of other opioids. DISCUSSION AND CONCLUSIONS These cases provide an alternative method for starting buprenorphine/naloxone that offers unique benefits compared to protocols previously described in the literature. SCIENTIFIC SIGNIFICANCE This method can be used to minimize barriers to opioid agonist therapy. (Am J Addict 2019;28:262-265).
Species of Contracaecum Parasitizing the Magellanic Penguin Spheniscus Magellanicus (Spheniscidae) from the Argentinean Coast

ABSTRACT Anisakid nematodes have a worldwide distribution and are associated with fishes, birds, and marine mammals from freshwater, brackish, and marine systems. The aims of this work are to report for the first time Contracaecum mirounga parasitizing the Magellanic penguin Spheniscus magellanicus, to report another Contracaecum species in the same host species, and to discuss the validity of Contracaeceum spheniscus. Several dead chicks, juveniles, and adults of S. magellanicus were collected along the Argentinean coast from 2002 to 2009. Nematodes were removed from digestive tracts and studied using both light and scanning electron microscopy. Nematode prevalences were 2.38% for C. mirounga and 12.5% for Contracaecum sp. Contracaecum mirounga was found in 1 penguin from Península Valdés, Chubut. This species is known as a specific parasite of marine mammals such as Pinnipedia, thereby suggesting that this nematode is not as specific as believed. Another species of Contracaecum sp. was found parasitizing 1 penguin from the Río de la Plata coast. It possessed an unusual interlabial morphology and arrangement of male caudal papillae. Despite the low prevalence, the distinct morphological features are convincing and support the presence of a new Contracaecum species. However, a formal description is not presented because sufficient male specimens are lacking. Finally, C. spheniscus is considered a junior synonym of Contracaecum pelagicum. Future molecular studies might be helpful to determine the real diversity of Contracaecum species parasitizing S. magellanicus considering the number of sibling species recognized among the anisakids.
Connectivity properties in the prefrontal cortex during working memory: a near-infrared spectroscopy study

Abstract. Working memory (WM) plays a crucial role in human brain functions. The application of brain connectivity analysis helps to understand the brain network properties in WM. Combination of functional and effective connectivity can provide new insights for exploring network attributes. Nevertheless, few studies have combined these two modes in WM. Near-infrared spectroscopy was used to investigate the connectivity properties in the prefrontal cortex (PFC) during n-back (0-back and 2-back) tasks by combining functional and effective connectivity analysis. Our results demonstrated that the PFC network showed small-world properties in both WM tasks. The characteristic path length was significantly longer in the 2-back task than in the 0-back task, while there was no obvious difference in the clustering coefficient between two tasks. Regarding the effective connectivity, the Granger causality (GC) was higher for right PFC→left PFC than for left PFC→right PFC in the 2-back task. Compared with the 0-back task, GC of right PFC→left PFC was higher in the 2-back task. Our findings show that, along with memory load increase, long range connections in PFC are enhanced and this enhancement might be associated with the stronger information flow from right PFC to left PFC.
Acute macular neuroretinopathy after blunt ocular trauma: A rare association

Acute macular neuroretinopathy (AMN) is a deep retinal ischemic manifestation. It has been reported after the use of sympathomimetics, childbirth, bee sting, oral contraceptives, flu-like illness, intravenous contrast agents and bodily trauma not directly involving the eyes. We report a case of AMN following blunt ocular trauma. An 18-year-old male presented with an acute history of blurring of vision following blunt trauma to the right eye. Spectral domain optical coherence tomography (SD-OCT) showed hyperreflectivity of the outer nuclear layer with ellipsoid layer disruption. This report highlights AMN as a manifestation of blunt trauma, presence of which may be an indicator of poor visual prognosis.
The role of relationship marketing to building loyalty on bank customers

This study aims to test the role of relationship marketing on customer loyalty. The research used quantitative approach with the survey method. Population of the research is all customer of BRI Bank in Kendari City Indonesia, where the respondent in this research are 77 customer. The cross sectional data was collect to measure of each variable research. Analysis research used Partial Least Squared (PLS) to test of the role of each relationship marketing variable to building customer loyalty. The results explained that;(a) communication has a significant role on trust; (b) handling problem has a non-significant role on trust; (c) communication has a significant role on commitment; (d) handling problem has non-significant role to commitment; (e)trust has a significant role on commitment; (f) communication has a non-significant role on loyalty; (g) handling problem has a non-significant role on loyalty; (h)trust has a significant role to customer loyalty; and (i) commitment has a significant role on loyalty. This study also found that the problem handling variable has no role in building customer loyalty. This study concludes that the BRI Bank is still not good in handling problems with their customers and the variables of trust and commitment play a significant role in mediating the role of communication in building customer loyalty. © 2020 by the authors. Licensee SSBFNET, Istanbul, Turkey. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Attitude and awareness of general population towards radiation hazards and safety: An institutional study

Context: Radiological investigations play a pivotal role in the diagnosis and treatment of a wide range of procedures. Aim: To assess the knowledge regarding adverse consequences of radiological examination and encourage awareness regarding radiation protection amongst general public. Settings and Design: A questionnaire-based cross-sectional study conducted amongst patients visiting the dental outpatient department. Materials and Methods: 1,000 adult male and female patients within the age of 20–70 years who visited the outpatient department during May–July 2017 were included in the study. Statistical Analysis: Comparison of frequencies of responses to each item with age and gender was done using chi square test. For all statistical tests, P < 0.05 was considered to be statistically significant, keeping α error at 5% and β error at 20%. Results: 85.3% participants had visited a hospital earlier and 69.3% had undergone the procedure of an X-ray earlier. Out of those patients, only 24.7% of the participants had any knowledge about the equipment or the procedure while taking a radiograph. 5.2% of the participants were given any safety measures during the radiological procedure. 14.4% had knowledge of the risks and hazards associated with radiation. Conclusions: This short study showed that there is a need for educating the general population about the hazards and risks associated with radiation exposure.
Functional mimetic of the G-protein coupled receptor CXCR4 on a soluble antibody scaffold

ABSTRACT G-protein coupled receptors (GPCRs) constitute major drug targets due to their involvement in critical biological functions and pathophysiological disorders. The leading challenge in their structural and functional characterization has been the need for a lipid environment to accommodate their hydrophobic cores. Here, we report an antibody scaffold mimetic (ASM) platform where we have recapitulated the extracellular functional domains of the GPCR, C-X-C chemokine receptor 4 (CXCR4) on a soluble antibody framework. The engineered ASM molecule can accommodate the N-terminal loop and all three extracellular loops of CXCR4. These extracellular features are important players in ligand recruitment and interaction for allostery and signal transduction. Our study shows that ASMCXCR4 can be recognized by the anti-CXCR4 antibodies, MEDI3185, 2B11, and 12G5, and that ASMCXCR4 can bind the HIV-1 glycoprotein ligand gp120, and the natural chemokine ligand SDF-1α. Further, we show that ASMCXCR4 can competitively inhibit the SDF-1α signaling pathway, and be used as an immunogen to generate CXCR4-specific antibodies. This platform will be useful in the study of GPCR biology in a soluble receptor context for evaluating its extracellular ligand interactions.
Subcutaneous Immunotherapy in Patients with Fagales Pollen-Induced Oral Allergy Syndrome

Oral allergy syndrome (OAS) is the most common food allergy-related condition in adults. This study aimed to investigate whether subcutaneous immunotherapy (SCIT) with Fagales pollen-containing extracts can improve the clinical symptoms of OAS in Korea. In total, 56 OAS patients were included: 19 subjects treated with SCIT, which included Fagales pollen extracts, and 37 not treated with immunotherapy (IT). We reviewed the patients' medical records and administered a telephone questionnaire at one point to assess baseline OAS features and changes in the patients' OAS and allergic rhinoconjunctivitis (ARC) symptoms after treatment. Only 12 patients who received SCIT and 15 patients that did not receive SCIT could report on changes in OAS symptoms after treatment because the other patients practiced strict avoidance of their culprit fruits and vegetables, and they could not respond to the status of OAS. SCIT reduced the severity of OAS (p=0.005). Nine of the 12 patients (75%) that received SCIT reported a more than 50% reduction in OAS symptoms. In contrast, only three of the 15 patients (20%) that did not receive IT reported more than a 50% reduction in OAS symptoms. SCIT also reduced the severity of ARC symptoms (p<0.001). The results indicate that SCIT with Fagales pollen-containing extracts is associated with improved OAS symptoms in Korea.
WHAT INNOVATION MEANS FOR THE ADOPTION OF ECO-INNOVATION IN A CHEMICAL COMPANY?

ABSTRACT There are internal and external factors that influence companies on the implementation of eco-innovation. This article aims to analyze what leads a chemical company from an emerging country to adopt eco-innovation. We developed a qualitative case study based on external and internal factors. The results indicate that the company focused mainly on Research and Development (R&D) and product innovation, emphasizing that innovation can bring advantages in the integration of eco-innovation in its processes. In relation to the drivers for adopting eco-innovation, the influence is more external, based on normative pressures, cooperation and technology. The main challenge is to align sustainable concepts with company strategy, while integrating innovation across departments, this did not drive eco-innovation strategies. Background research on eco-innovation can help policymakers guide and predict corporate behavior and develop mechanisms to encourage environmental management. Keywords: Eco-Innovation. Chemical Industry. Sustainability. RESUMO Fatores internos e externos podem influenciar a implementacao de ecoinovacao nas empresas. Este artigo tem como objetivo analisar o que leva uma empresa quimica de um pais emergente a adotar uma ecoinovacao. Por meio de um estudo de caso qualitativo, com base nos fatores externos e internos, observou-se que a empresa e focada principalmente em Pesquisa e Desenvolvimento (P&D) e inovacao de produto, enfatizando que inovacao pode trazer vantagens na integracao da ecoinovacao em seus processos. Em relacao aos direcionadores para adocao da ecoinovacao, a influencia e mais externa, pelas pressoes normativas, cooperacao e tecnologia. O principal desafio e alinhar sustentabilidade a estrategia da empresa. A inovacao e transversalmente integrada nos departamentos, mas isso nao impulsionou estrategias de ecoinovacao. Pesquisas sobre antecedentes da ecoinovacao podem ajudar os formuladores de politicas a orientar e prever o comportamento das empresas e desenvolver mecanismos para estimular uma gestao ambiental. Palavras-chave: Ecoinovacao. Industria Quimica. Sustentabilidade.
Low water access as a gendered physiological stressor: Blood pressure evidence from Nepal

The study aims to test novel proposed biocultural pathways linking the stressful lived experience of water insecurity to elevated blood pressure, a risk factor for chronic disease. Using the case of Nepal, where women have primary responsibility for managing household water, allows testing for potentially gendered mechanisms that exacerbate negative physiological consequences of water insecurity for women relative to men.
Environmental Toxicology and Chemistry

Neonicotinoids are widely used insecticides that are detectable in agricultural waterways. These insecticides are of concern due to their potential impacts on nontarget organisms. Pesticides can affect development of amphibians and suppress the immune system, which could impact disease susceptibility and tolerance. No previous studies on amphibians have examined the effects of these insecticides on differential blood cell proportions or concentrations of corticosterone (a general stress hormone). We investigated the effects of chronic exposure to 2 neonicotinoids, thiamethoxam and clothianidin, on immunometrics of wood frogs (Lithobates sylvaticus). Frogs were exposed to single, chronic treatments of 2.5 or 250 μg/L of clothianidin or thiamethoxam for 7 wk from Gosner stages 25 to 46. The juvenile frogs were then maintained for 3 wk post metamorphosis without exposure to neonicotinoids. We measured water‐borne corticosterone twice: at 6 d and 8 wk after exposure in larval and juvenile frogs, respectively. We assessed differential blood cell profiles from juvenile frogs. Corticosterone was significantly lower in tadpoles exposed to 250 μg/L of thiamethoxam compared with other tadpole treatments, but no significant differences in corticosterone concentrations were found in treatments using juvenile frogs. Anemia was detected in all treatments compared with controls with the exception of tadpoles exposed to 2.5 μg/L of clothianidin. Neutrophil‐ to‐leukocyte and neutrophil‐to‐lymphocyte ratios were elevated in frogs exposed to 250 μg/L of thiamethoxam. Collectively, these results indicate that chronic exposure to neonicotinoids has varied impacts on blood cell profiles and corticosterone concentrations of developing wood frogs, which are indicative of stress. Future studies should investigate whether exposure to neonicotinoids increases susceptibility to infection by parasites in both larval and adult wood frogs. Environ Toxicol Chem 2019;38:1273–1284. © 2019 Crown in the right of Canada. Published by Wiley Periodicals Inc. on behalf of SETAC.
The Combination of Physical Activity and Sedentary Behaviors Modifies the Genetic Predisposition to Obesity

This study aimed to investigate whether the association between a validated genetic profile risk score for BMI (GPRS‐BMI) (based on 93 single‐nucleotide polymorphisms) and phenotypic obesity (BMI) was modified by the combined categories of physical activity (PA) and sedentary behaviors in a large population‐based study.
Оцінка ефективності організаційних стратегій

Постановка проблеми: стаття доповнює попередні дослідження і фокусується на методах оцінки ефективності. Крім того, слід зазначити, що в цьому дослідженні розглядається збалансована система показників. Модель збалансованої системи показників з чотирма вимірами життєво важливих фінансових, внутрішніх процесів, клієнтів, навчання і зростання намагається контролювати короткострокові операції організації з її довгостроковим баченням і стратегіями. Тому організація фокусується на ключових показниках ефективності в рамках цілей. Мета: в статті робиться спроба визначити детермінанти для пошуку оцінки ефективності впливу організації з допомогою методу збалансованих показників в результатах діяльності організації. Вхідні дані: в дослідженні використовувалося анкетування, яке включає в себе 28 питань, і для кожної картки балансу розглядається 7 балів. Також слід вказати, що дані є результатом опитування 60 осіб. Методи: в дослідженні використовувалося програмне забезпечення Mini-Tab для обчислення значень z і p-значення зі значним рівнем 0,05 для 28 питань. Якщо припущення на значущому рівні становить 0,05, ми приймаємо інакше, і страхова організація між 10-30 роками проектує стратегічні цілі. В середньому 6 вважається за перевірку гіпотез. Результати: результати дослідження гіпотези показують, що допущення H1 є прийнятним. Іншими словами, ми можемо сказати, що всі чотири аспекти збалансованої оціночної карти: фінансові, клієнтські, внутрішні процеси та перспективи зростання і навчання призводять до досягнення цілей стратегії організації. Висновок: у відношенні згаданих випадків можна сказати, що страхова компанія досягла своїх цілей, і доречна функція вирівнювання по чотирьох напрямках.
Evaluation of sucrose and GA3 in an in vitro shoot culture of Alpinia purpurata (Zingiberaceae)

Alpinia purpurata is an ornamental plant species native to the Asia-Pacific with commercial potential due to its red inflorescence adapted to the northern Colombian coast; however, the lack of propagation protocols hinders commercial cultivation. To adjust a micropropagation protocol for clonal plant material production, the aim of this study was to evaluate the effect of sucrose and gibberellic acid (GA3) in the culture medium on the number of new shoots per explant, shoot length, root number, root length and number of leaves. Explants were cultured in semisolid MS (Murashige & Skoog) medium with sucrose (30, 45 and 60 mg/L) and GA3 (0.0; 0.25; 0.5; 0.75 and 1.0 mg/L). A factorial experimental design with two factors was employed, with 15 treatments, 10 replicates per treatment and 150 experimental units distributed with a completely randomized design. Cultures were stored five weeks at 25 °C with a 12 h photoperiod (40 μmol m-2 s-1). Anova and Tukey’s test allowed detecting the statistical effects of sucrose and GA3 supply for all variables. An increase in sucrose concentration resulted in a higher number of shoots, while an increase in GA3 induced longer shoots. Root length and leaf number decreased as GA3 and sucrose increased.
Trash to treasure Retcam

Digital fundus imaging is being used in diagnosis, documentation, and sharing of many retinal diseases and hence forms an essential part of ophthalmology. The use of smartphones for the same has been ever increasing. There is a need for simpler devices to couple the 20D lens and smartphone so as to take fundus photographs which can help in fundus documentation. This article describes a simple inexpensive technique of preparing a smartphone fundus photography device (Trash To Treasure (T3) Retcam) from the used materials in the clinics within minutes. This article will also review the optical principles of the T3 Retcam and describe the step–by–step method to record good-quality retinal image/videos. This inexpensive device is made by recycling and modifying the plastic hand sanitizer bottle in the clinics/hospitals which can be used for documenting, diagnosing, screening, and academic purposes.