Miracle-dz/UniFAR-FTUs huggingface dataset:
Association of common mental disorders and related multimorbidity with subsequent labor market marginalization among refugee and Swedish-born young adults

Background Common mental disorders (CMDs), multimorbidity, and refugee status are associated with poor labor market outcome. Little is known about how these factors interact in young adults. Objective We aimed to i) investigate whether the association of CMDs and multimorbidity with labor market marginalization (LMM) differs between refugee and Swedish-born young adults and ii) identify diagnostic groups with particularly high risk for LMM. Methods This longitudinal registry-based study included individuals aged 20–25 years followed from 2012 to 2016 in Sweden (41,516 refugees and 207,729 age and sex-matched Swedish-born individuals). LMM was defined as granted disability pension (DP) or > 180 days of unemployment (UE). A disease co-occurrence network was constructed for all diagnostic groups from 2009 to 2011 to derive a personalized multimorbidity score for LMM. Multivariate logistic regression was used to estimate odds ratios of LMM in refugee and Swedish-born youth as a function of their multimorbidity score. The relative risk (RR, 95% CI) of LMM for refugees with CMDs compared to Swedish-born with CMDs was computed in each diagnostic group. Results In total, 5.5% of refugees and 7.2% of Swedish-born with CMDs were granted DP; 22.2 and 9.4%, respectively received UE benefit during follow-up. While both CMDs and multimorbidity independently elevated the risk of DP considerably in Swedish-born, CMDs but not multimorbidity elevated the risk of UE. Regarding UE in refugees, multimorbidity with the presence of CMDs showed stronger estimates. Multimorbidity interacted with refugee status toward UE (p < 0.0001) and with CMDs toward DP (p = 0.0049). Two diagnostic groups that demonstrated particularly high RR of UE were schizophrenia, schizotypal and delusional disorders (RR [95% CI]: 3.46 [1.77, 6.75]), and behavioral syndromes (RR [95% CI]: 3.41 [1.90, 6.10]). Conclusion To combat LMM, public health measures and intervention strategies need to be tailored to young adults based on their CMDs, multimorbidity, and refugee status.
Enhanced electromechanical properties in all-polymer percolative composites

In this letter, we discuss the enhanced electrostriction and dielectric constant in an all-polymer percolative composite consisting of poly(vinylidene fluoride-trifluoroethylenechlorotrifluoroethylene) [P(VDF–TrFE–CTFE)] terpolymer matrix and polyaniline (PANI) conductive particles. Using a self-consistent approach, we calculate the dielectric constant and dielectric loss tangent of the composite in excellent agreement with experiments, and demonstrate that the electrostriction enhancement is due to the electric field fluctuation in P(VDF–TrFE–CTFE) matrix, which becomes dominant when the dielectric constant of the second phase is much larger than that of the matrix. The inhomogeneous field distribution in the matrix has also been used to estimate the breakdown field of the composite, which agrees well with experimental measurement. The study could be used to design and optimize electrostrictive composites with optimal electromechanical properties.
Electron backscattering from thin films

The basic principles of electron backscattering from atoms and solids in the energy range 10 to 100 keV are reviewed. The total backscattering from thin self‐supporting films, from bulk solids, and from thin surface films on supporting bulk solids is discussed as well as the angular distribution of the backscattered electron intensity for normal and for oblique incidence of the primary beam. The results of theoretical models are compared with experimental results. Contrast mechanisms in scanning electron microscopy based on electron backscattering and the influence of diffraction effects are described. Finally the thickness determination of thin films by electron backscattering and by other methods is reviewed.
Comparative Gut Microbiome Differences between High and Low Aortic Arch Calcification Score in Patients with Chronic Diseases

Gut dysbiosis can induce chronic inflammation and contribute to atherosclerosis and vascular calcification. The aortic arch calcification (AoAC) score is a simple, noninvasive, and semiquantitative assessment tool to evaluate vascular calcification on chest radiographs. Few studies have discussed the relationship between gut microbiota and AoAC. Therefore, this study aimed to compare the microbiota composition between patients with chronic diseases and high or low AoAC scores. A total of 186 patients (118 males and 68 females) with chronic diseases, including diabetes mellitus (80.6%), hypertension (75.3%), and chronic kidney disease (48.9%), were enrolled. Gut microbiota in fecal samples were analyzed by sequencing of the 16S rRNA gene, and differences in microbial function were examined. The patients were divided into three groups according to AoAC score, including 103 patients in the low AoAC group (AoAC ≤ 3), 40 patients in the medium AoAC group (3 < AoAC ≤ 6), and 43 patients in the high AoAC group (AoAC > 6). Compared to the low AoAC group, the high AoAC group had a significantly lower microbial species diversity (Chao1 index and Shannon index) and increased microbial dysbiosis index. Beta diversity showed that the microbial community composition was significantly different among the three groups (p = 0.041, weighted UniFrac PCoA). A distinct microbial community structure was found in the patients with a low AoAC, with an increased abundance at the genus level of Agathobacter, Eubacterium coprostanoligenes group, Ruminococcaceae UCG-002, Barnesiella, Butyricimonas, Oscillibacter, Ruminococcaceae DTU089, and Oxalobacter. In addition, there was an increased relative abundance of class Bacilli in the high AoAC group. Our findings support the association between gut dysbiosis and the severity of AoAC in patients with chronic diseases.
Incidence of SARS-CoV-2 Co-infections During the Second Wave in Sub-Himalayan Region, India

Introduction The second wave of the coronavirus disease 2019 (COVID-19) pandemic in India, which started from April 2021, has been more severe and deadly than the first wave. The aim of this prospective study was to determine the possibility of other respiratory pathogens contributing towards the severity and hospitalization in the current second wave. Materials and methods Nasopharyngeal and oropharyngeal swab samples were collected and processed for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by reverse transcription polymerase chain reaction (RT-PCR). These samples were further processed for detection of co-infection in SARS CoV-2 patients by BioFire® Filmarray® 2.0 (bioMérieux, USA). Results We screened 77 COVID-19-positive patients admitted to All India Institute of Medical Sciences (AIIMS), Rishikesh and found cases of co-infections in five (6.49 %) patients. Conclusion Our finding suggests that co-infections had no or minimal role in augmenting the second wave of the COVID-19 pandemic in India, and the emergence of new variants may be the probable cause.
Audio quantization from a receding horizon control perspective

By introducing psycho-acoustical aspects, the audio quantization problem is translated into a finite horizon optimal control problem with a finite input constraint set. An explicit solution is obtained. Its receding horizon implementation gives rise to the receding horizon quantizer (RHQ). The RHQ corresponds to a closed loop, which embeds the widely-adopted noise shaping quantizer in a broader framework and allows for enhanced performance. Furthermore, suboptimal algorithms are described and their behaviour illustrated by means of an example.
Evaluation of Depth-Limited Wave Breaking Criteria

Numerous criteria exists for predicting incipient wave breaking. These criteria were verified with a limited number of data sets or under limited number of data sets or under limited beach and wave conditions, and confusion exists as to which of the many criteria to use. In the present study, a large database of wave breaking parameters from 17 laboratory experiments with plane slopes was complied to yield 416 data points, of which 409 were used in empirical correlations to develop predective breaking criteria covering the widest possible range available of beach and wave conditions. Selected criteria were evaluated and empirical coefficients adjusted by iterative best-fit procedures involving bin averaging of widely scattered parameter values to reveal functional dependencies. High-predictive capability was obtained using simple criteria expressed in terms of beach slope and wave steepness, and new criteria were developed for three breaking wave ratios or breaker indices: wave height to water depth at incipient breaking; incipient breaking wave height to deep-water wave height; and water depth at incipient breaking to deep-water wave height.
Sighting Dominance, Biometric Parameters, and Refractive Status Analyzing the Role of Ocular Dominance

Objectives: The purpose was to study the association between ocular dominance, refractive status, and biometric parameters. Methods: Ocular dominance was assessed on consenting participants with non-pathological eyes using “hole-in-the-card test. ” The participants were then examined for visual acuity, biometric measurements, and refraction. Data were analyzed using IBM SPSS software. Results: Among a total of 660 participants in our study, right eye dominance was found in 508 (76.97%) participants. We found that horizontal keratometry readings (K1) were greater in the dominant eye compared to the non-dominant eye, showing a statistically significant difference in emmetropes (p<0.001) and hyperopes (p<0.001). The axial length was found to be longer but not significantly greater in dominant eye among while it was significant among myopes (p<0.001) and hyperopes (p<0.001). In myopic anisometropes, the axial length was significantly longer and more myopic in the dominant eye (24.0±0.7 mm) than non-dominant eye (23.9±0.4 mm) while the non-dominant eye was more hyperopic in anisometropic hyperopes. Conclusion: Right eye was dominant in majority of participants. The dominant eye was more myopic and had greater axial length in anisometropes. The dominant eye was more astigmatic than the non-dominant eye. Visual acuity was not affected by ocular dominance. The mean difference in biometric measurements was significantly greater in hyperopic eyes. The assessment of ocular dominance could improve patient satisfaction in refractive surgeries and monovision treatments. Treatment protocols could be fine-tuned based on ocular dominance. Normative data in various biometric measurements could take into consideration laterality in terms of dominance.
On the eigenvalues of Redheffer's matrix, II

Abstract The Redheffer matrix An = (aij)n×n defined by aij = 1 when i|j or j = 1 and aij = 0 otherwise has many interesting number theoretic properties. In this paper we give fairly precise estimates for its eigenvalues in punctured discs of small radius centred at 1.
Multivariate Linear Regression Model with Elliptically Contoured Distributed Errors and Monotone Missing Dependent Variables

In this article, the multivariate linear regression model is studied under the assumptions that the error term of this model is described by the elliptically contoured distribution and the observations on the response variables are of a monotone missing pattern. It is primarily concerned with estimation of the model parameters, as well as with the development of the likelihood ratio test in order to examine the existence of linear constraints on the regression coefficients. An illustrative example is presented for the explanation of the results.
Does Physical Exercise Enhance the Immune Response after Vaccination? A Systematic Review for Clinical Indications of COVID-19 Vaccine

Background: Stimulating protective immunity with vaccines appears to be the most promising option for providing widespread moderate to high protection against COVID-19 in people over the age of 18. Regular exercise improves the immune response, transmitting possible benefits against virus infections. The aim of this review is to study the effects of physical activity on vaccine injections, helping to develop new recommendations for COVID-19 vaccination campaigns. Methods: A comprehensive review of the existing literature was undertaken using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The internal quality of the studies was assessed according to the Physiotherapy Evidence Database (PEDro) scale. The outcomes analyzed were antibody titer, the level of lymphocytes CD4, CD8, InterLeukin 6 (IL6), leukocytes level, the visual analogue scale (VAS) for overall pain rating, arm and forearm circumferences and volume of oxygen (VO2) peak. Results: Fourteen articles were selected for the analysis. The majority of studies were randomized controlled trials (RCT) (n = 8) and controlled trials (CT) (n = 6). According to PEDro, the ‘fair’ category (n = 7) was the most represented, followed by ‘good’ (n = 6) and ‘excellent’ (n = 1). Physical training showed a positive effect on antibody titers of the vaccine; yet, different variables seem to influence antibody titers: higher new vs. old antigen in the vaccine, higher in younger vs. older individuals, and higher in females vs. males. After exercise, when analyzing variables of direct response to the vaccine, such as the amount of CD4, IL-6 and leukocytes, higher levels were observed in the patients who performed physical exercise compared to the control group. In the same way, better results were observed in physiological variables such as VO2 and limb circumferences, or subjective variables such as pain, which showed better results than the control group. Conclusions: The immune response (antibody titers) depends on age, gender and the intensity of physical activity: long-term protocols at moderate intensity are the most recommended. All of these aspects also have to be carefully considered for the COVID-19 vaccination.
Disrupted structural connectivity and less efficient network system in patients with the treatment-naive adult attention-deficit/hyperactivity disorder

Introduction Attention-deficit/hyperactivity disorder (ADHD) is a neuropsychiatric disorder whose primary symptoms are hyperactivity, impulsivity, and inattention. Historically, ADHD was recognized as a disease of childhood and adolescence. However, many patients are known to have persistent symptoms into adulthood. Many researchers consider the neuropathology of ADHD to be based on abnormalities in multiple parallel and intersecting pathways rather than a single anatomical area, but such alterations remain to be clarified. Methods Using diffusion tensor imaging, we investigated differences in the global network metrics estimated by graph theory and the degree of connectivity between adjacent voxels within a white matter (WM) fascicle defined by the density of the diffusing spins (connectometry) between 19 drug-naive Japanese patients with adult ADHD and 19 matched healthy controls (HCs). In adult patients with ADHD, we examined the relationships between the symptomatology of ADHD and global network metrics and WM abnormalities. Results Compared with HCs, adult patients with ADHD showed a reduced rich-club coefficient and decreased connectivity in widely distributed WMs such as the corpus callosum, the forceps, and the cingulum bundle. Correlational analyses demonstrated that the general severity of ADHD symptoms was associated with several global network metrics, such as lower global efficiency, clustering coefficient, small worldness, and longer characteristic path length. The connectometry revealed that the severity of hyperactive/impulsive symptoms was associated with overconnectivity in the corticostriatal, corticospinal, and corticopontine tracts, the inferior fronto-occipital fasciculus, and the extreme capsule but dysconnectivity in the cerebellum. The severity of inattentive symptoms was associated with dysconnectivity in the intracerebellar circuit and some other fibers. Conclusion The results of the present study indicated that patients with treatment-naive adult ADHD showed disrupted structural connectivity, which contributes to less efficient information transfer in the ADHD brain and pathophysiology of ADHD. Trial registration UMIN Clinical Trials Registry (UMIN-CTR) UMIN000025183, Registered: 5 January 2017.
Some aspects of the convective boundary layer over the Bay of Bengal

SE HA LLEVADO A CABO UN ESTUDIO PARA INVESTIGAR LAS CARACTERISTICAS REMODINAMICAS DE LA CAPA LIMITE (CBL) SOBRE LA REGION DE LA BAHIA DE BENGALA. CON TAL FIN HAN SIDO CONSIDERADAS UNAS OBSERVACIONES AEROLOGICAS COLECTADAS DEL MONZON 77 EMPLEANDO LAS NAVES DE INVESTIGACION DE LA, EN OTRO TIEMPO, UNION DE REPUBLICAS SOCIALISTAS SOVIETICAS (URSS) (ES DECIR, SHIRSHOV, PROBOY, SHOKALSKY Y OKEAN) EN LA REGION 15-19°N, 87-91°E DURANTE 11 A 18 DE AGOSTO DE 1977 Y BOBMEX-98 A BORDO DE SAGAR KANYA EN 13°N, 87°E. LOS RESULTADOS DEL ANALISIS DE CUATRO BARCOS MOSTRARON QUE NO SE ENCUENTRAN DIFERENCIAS MARCADAS EN LAS CARACTERISTICAS DE LA CAPA LIMITE CONVECTIVA DURANTE LE PERIODO EN CUESTION, PERFILES VERTICALES SEIS HORARIOS DE LOS PARAMETROS TERMODINAMICOS MOSTRARON UNA EVOLUCION DE LA ESTRUCTURA DE LA CAPA LIMITE CONVECTIVA (CBL) DURANTE EL DIA EN TODOS LOS SITIOS, LA CIMA DE LA CBL SE ENCUENTRA ENTRE LOS 700-580 HPA Y VARIA CON EL TIEMPO CRONOLOGICO. LOS VALORES SEIS HORARIOS DE LOS PARAMETROS METEOROLOGICOS, A SABER: P, T Y TD MOSTRARON VARIACIONES. ES EVIDENTE TAMBIEN QUE LOS PARAMETROS METEOROLOGICOS EN SUPERFICIE, ASI COMO LA ESTRUCTURA DE LA CBL SOBRE LA REGION MENCIONADA ARRIBA ESTA INFLUENCIADA POR LAS CONDICIONES METEOROLOGICAS PREDOMINANTES Y LAS PERTURBACIONES ASOCIADAS CON LAS PERTURBACIONES A ESCALA SINOPTICA TRANSITORIAS.
Unsteady Performance of a Double Entry Turbocharger Turbine With a Comparison to Steady Flow Conditions

Circumferentially divided, double entry turbocharger turbines are designed with a dividing wall parallel to the machine axis such that each entry feeds a separate 180 deg section of the nozzle circumference prior to entry into the rotor. This allows the exhaust pulses originating from the internal combustion exhaust to be preserved. Since the turbine is fed by two separate unsteady flows, the phase difference between the exhaust pulses entering the turbine rotor will produce a momentary imbalance in the flow conditions around the periphery of the turbine rotor. This research seeks to provide new insight into the impact of unsteadiness on turbine performance. The discrepancy between the pulsed flow behavior and that predicted by a typical steady flow performance map is a central issue considered in this work. In order to assess the performance deficit attributable to unequal admission, the steady flow conditions introduced in one inlet were varied with respect to the other. The results from these tests were then compared with unsteady, in-phase and out-of-phase pulsed flows most representative of the actual engine operating condition.
Response of GaAs displacement damage monitors to protons, electrons, and gamma radiation

The need to characterize the radiation hardness of certain classes of devices in terms of atomic displacement damage rather than total absorbed dose is addressed. Resistive-network displacement damage monitors irradiated with 1.0-MeV protons and 7.3-MeV electrons indicate that these radiations are both about twenty times as damaging as /sup 60/Co gamma radiation for the same total absorbed dose. Preliminary results are presented on an alternative monitor consisting of a GaAs LED (light-emitting diode) that offers a two-order-of-magnitude increase in sensitivity over the resistive network monitors. Other characteristics of the two monitors, such as range, linearity, annealing and reuse, and neutron sensitivity, are compared. >
Pan-cancer analysis identifies PD-L2 as a tumor promotor in the tumor microenvironment

Background Programmed cell death protein 1 (PD-1) receptor has two ligands,programmed death-ligand 1 (PD-L1) and PD-L2. When compared with PD-L1, PD-L2 has not received much attention, and its role remains unclear. Methods The expression profiles of pdcd1lg2 (PD-L2-encoding gene) mRNA and PD-L2 protein were analyzed using TCGA, ICGC, and HPA databases. Kaplan-Meier and Cox regression analyses were used to assess the prognostic significance of PD-L2. We used GSEA, Spearman’s correlation analysis and PPI network to explore the biological functions of PD-L2. PD-L2-associated immune cell infiltration was evaluated using the ESTIMATE algorithm and TIMER 2.0. The expressions of PD-L2 in tumor-associated macrophages (TAMs) in human colon cancer samples, and in mice in an immunocompetent syngeneic setting were verified using scRNA-seq datasets, multiplex immunofluorescence staining, and flow cytometry. After fluorescence-activated cell sorting, flow cytometry and qRT-PCR and transwell and colony formation assays were used to evaluate the phenotype and functions of PD-L2+TAMs. Immune checkpoint inhibitors (ICIs) therapy prediction analysis was performed using TIDE and TISMO. Last, a series of targeted small-molecule drugs with promising therapeutic effects were predicted using the GSCA platform. Results PD-L2 was expressed in all the common human cancer types and deteriorated outcomes in multiple cancers. PPI network and Spearman’s correlation analysis revealed that PD-L2 was closely associated with many immune molecules. Moreover, both GSEA results of KEGG pathways and GSEA results for Reactome analysis indicated that PD-L2 expression played an important role in cancer immune response. Further analysis showed that PD-L2 expression was strongly associated with the infiltration of immune cells in tumor tissue in almost all cancer types, among which macrophages were the most positively associated with PD-L2 in colon cancer. According to the results mentioned above, we verified the expression of PD-L2 in TAMs in colon cancer and found that PD-L2+TAMs population was not static. Additionally, PD-L2+TAMs exhibited protumor M2 phenotype and increased the migration, invasion, and proliferative capacity of colon cancer cells. Furthermore, PD-L2 had a substantial predictive value for ICIs therapy cohorts. Conclusion PD-L2 in the TME, especially expressed on TAMs, could be applied as a potential therapeutic target.