Miracle-dz/UniFAR-FTUs huggingface dataset:
An ABCG-Type Transporter Facilitates ABA Influx and Regulates Camptothecin Biosynthesis in Camptotheca acuminata

Camptothecin (CPT) and its derivatives from Camptotheca acuminata have antitumor effects as a DNA topoisomerase I inhibitor. Previous studies have shown that application of exogenous abscisic acid (ABA) significantly promoted the accumulation level of CPT and induced the expression of CPT biosynthetic genes, which revealed that ABA signaling is effectively involved in regulating CPT biosynthesis in C. acuminata. In this study, an ABA transporter, CaABAT, which encodes a plasma membrane protein belonging to the ABCG subfamily, was identified in C. acuminata, and its ABA import activity was confirmed by transport assay in yeast cells. Real-time PCR analysis showed that CaABAT was predominately expressed in C. acuminata leaves and its expression could be significantly upregulated by exogenous ABA treatment. Silencing of CaABAT down-regulated the expression of ABA response genes, which indicated that translocation of ABA by CaABAT should initiate changes in plant physiological status in response to ABA signaling, thus leading to decreased expression of CPT biosynthesis pathway genes and low accumulation levels of CPT in C. acuminata.
Bullying Victimization and Quality of Life among Chinese Adolescents: An Integrative Analysis of Internet Addiction and Social Withdrawal

Bullying victimization has been proven to be a direct predictor of adolescents’ quality of life, whereas elaborate mechanisms remain inconclusive. This study aims to explore the mediating pathway of Internet addiction and social withdrawal on the relationship between bullying victimization and quality of life among Chinese adolescents. This study used the cross-sectional data collected by self-reported questionnaires, including multidimensional peer-victimization scale, youth quality of life instrument-short form, prolonged social withdrawal questionnaire, and compulsive Internet use scale. A total of 1278 participants from four junior middle schools and two high schools participated in the questionnaire survey. SPSS 25.0 and Amos 25.0 were adopted to analyze the data. The results indicated that bullying victimization was directly and indirectly associated with adolescents’ quality of life. Internet addiction and social withdrawal partially mediated the relationship between bullying victimization and quality of life among adolescents. The current study demonstrated the underlying pathway of how bullying victimization affected adolescents’ quality of life, which could provide an intervention perspective for governments and social workers to improve adolescents’ quality of life by controlling Internet addiction and social withdrawal.
On some topologies which coincide on the unit sphere of the Fourier-Stieltjes algebra $B(G)$ and of the measure algebra $M(G)$

Introduction. Let G be an arbitrary locally compact group [T(G)], 5(G) the [Fourier] Fourier-Stieltjes algebra of G and M(G) the Banach algebra of bounded Radon measures on G (see definitions in what follows). We prove in §1 of this paper that we w*-topology tw* and the multiplier topology tm coincide on the unit sphere A = {we 5(G); ||w|| = 1} of 5(G), where ua -* u in vM if and only if \\(ua — w)v|| -+ 0 for each v e T(G). This result proves a conjecture of McKennon [10, p. 49], It improves a result of Derighetti [1] and McKennon [10] (that tw— vuc on S, where tuc is the topology of uniform convergence on compacta) which in turn improves a theorem of Raikov [13] and Yoshizawa [17] (that = tuc on the positive definite face of 5). Applying this result we show in theorem Bx that for any compact K <= G the Banach space AK(G) = {w e A(G); supp u c K} has the Radon-Nikodym property and consequently a strong Krein-Milman theorem, for closed bounded convex subsets of T^(G), follows. Theorem 52 of this section consists of a long list of topologies which coincide on S. §3 consists of a measure theoretical selfcontained proof of a result of McKennon [10] which states that the w* and the ZAmultiplier topology on 5 = {//e A/(G); ||//|| = 1} coincide {/j.a -> // in the latter if and only if ||(/za — /z)*/|l/> “* 0 f°r each /6 5^). The reader familiar with [10, pp. 21-25 and 32-33] will find, we think, that our proof is simpler, more natural and self-contained. Finally we investigate in §2, subsets of B^(G) (the space of multipliers of zl^(G)) on which the topologies tm and a(B^, L1) coincide. As a consequence a necessary and sufficient condition for a subset of Ap(G) to be norm compact is given (in case G is amenable). In view of [8] the results seem to be of interest even for the nonamenable case.
Plasma structures of Kelvin-Helmholtz billows at the duskside flank of the magnetotail

[1] A multiple magnetopause crossing event on 24 March 1995 is examined to investigate the structures of plasma in the boundary regions of the magnetotail. The event was observed by Geotail crossing the magnetopause at the duskside flank of the near-Earth magnetotail. The interplanetary magnetic field had been sustained northward for more than 6 h before the event. Repeated patterns of variations in the temperature and density of plasma suggest strongly the presence of Kelvin-Helmholtz billows on the magnetopause. In agreement with previous papers, a magnetospheric region, termed the magnetotail low-latitude boundary layer (T-LLBL), is identified where parallel anisotropic ions flow tailward with the speed slower than ∼150 km/s. A new finding is that there is a region, termed the low-latitude interactive region (T-LLIR), filled with isotropic ions flowing tailward with the speed of ∼150 km/s between the magnetopause and the T-LLBL. The T-LLIR was found on the surface of magnetospheric billows but seemed not to exist near the trough between billows. The energy spectrum of the ion momentum (“the momentum spectrum” for simplicity) is first introduced to examine the characteristics of these boundary regions. It is shown that the momentum spectra in different regions show different profiles. The profile in the T-LLIR looks like an intermediate of those obtained in the magnetosheath and the T-LLBL. Using a multivariate Maxwellian mixture model, it is found that the distribution function of ions in the T-LLIR is composed of two cold components and one hot component. A significant feature in this model is that the bulk speed of a hotter component is faster. In contrast, the bulk speeds of the three Maxwellian components are nearly equal to each other in the T-LLBL. These characteristics in the distribution functions are responsible for the differences in the momentum spectra. The role of the T-LLIR in momentum and particle transportation to the magnetosphere from the magnetosheath is discussed.
Simple phase optical elements for narrowing of a focal spot in high-numerical-aperture conditions

Abstract. It is shown that a decrease in the size of the focal spot produced by a high numerical aperture focusing system comes as the result of the spatial redistribution of different electric field components in the focal region. The focal distribution of electric field components can be controlled using vortex or binary phase diffractive elements. Situations for differently polarized incident laser beams are discussed and illustrated.
DACLATASVIR DIHYDROCHLORIDE MICROSPHERES, PROCESS PARAMETERS FOR ENHANCED PERMEABILITY AND LIVER TARGETING

Objectives: Daclatasavir dihydrochloride (DCLD) is used to treat hepatitis C. DCLD can be used to patients with all stages of compensated liver disease including cirrhosis. The aim of the present study was to develop DCLD microspheres to improve the permeation and maximum accumulation in the liver and in vitro evaluation. Methods: DCLD microspheres were prepared with chitosan polymer using emulsion crosslinking technique. Twelve formulations were prepared, that is, F1-F12. The microspheres were evaluated for morphology, particle size, encapsulation efficiency, % yield, and permeability. FTIR studies were conducted on optimized formulation to check the drug-excipient compatibility. Results: The particle size of microspheres was in the range of 11.50±0.08 μm to 98.50±0.05 μm. Encapsulation efficiency of the formulations was observed in the range 47.8–69.2%. The ex vivo permeation studies revealed that 83.3±0.1% of drug was diffused from microspheres in 60 min, whereas from pure drug 49±0.7% of drug was diffused in 60 min. Conclusion: DCLD microspheres were shown good permeability when compared to pure drug which will improve the absorption.
Linear and Nonlinear Susceptibilities in Cu97Co3 Alloy for Ferromagnetic Fine Particles in Metallic Matrix: Comparison with Spin Glass Au96Fe4 Alloy

The ac linear (χ 0 ) and nonlinear (χ 2 ) susceptibilities of ferromagnetic fine cobalt particles, which were precipitated in a Cu 97 Co 3 alloy, have been studied. The linear susceptibility χ 0 has a spin-glass-like maximum at low temperature. The nonlinear susceptibility χ 2 is negative and has a peak around the temperature where χ 0 exhibits the maximum. However, the negative peak in χ 2 is very broad compared with that of spin glasses. Furthermore, χ 2 is proportional to T -3 at high temperatures. This behavior of χ 2 in the Cu 97 Co 3 alloy is essentially different from the divergent behavior of χ 2 in spin glasses.
Knowledge, Attitudes, and Behaviors Regarding Lyme Borreliosis Prevention in the Endemic Area of Northeastern Poland

(1) Background: The incidence of Lyme borreliosis (LB) is increasing in Europe. The new LB vaccine is still in clinical development, thus the dissemination of knowledge about the disease is essential. We assessed the knowledge, attitudes and preventive practices (KAP) against tick-borne diseases (TBDs) of people living in the endemic area in northeastern Poland. (2) Methods: We surveyed 406 adults using a 37-item anonymous paper survey. The data were analyzed with regression models. (3) Results: The two most popular knowledge sources were the Internet and doctors, selected by 77.8% and 53.4%, respectively. Respondents felt moderately knowledgeable about TBDs and tick bite prophylaxis (median scores 5/10, and 6/10, respectively), considered TBDs to be a significant health threat (median 8/10), attributed high risk to tick mouthparts remaining in the skin after tick removal (median 10/10), and shared multiple misconceptions regarding LB transmission, symptoms, and management. General knowledge scores (GKS) about TBDs and tick protection practices scores (TPS) were moderate (65.0%; IQR, 55.8–71.7%, 63.6%; 54.5–72.7%, respectively). Only 48.0% had a positive attitude towards TBE vaccination. A recent tick-bite was associated with higher GKS (OR, 2.55; 95% CI, 1.27–5.10; p = 0.008), higher TPS (OR 4.76, 95% CI, 2.0–11.1; p < 0.001), and a positive attitude towards TBE vaccine (OR 2.10, 1.07–4.10, p = 0.030). A positive vaccine attitude was also associated with obtaining TBD knowledge from doctors and other verified sources (OR, 2.654, 1.66–4.23; p < 0.001). Age, place of residence, and frequent exposure to ticks in green areas were not associated with GKS, TPS, nor vaccine attitude. (4) Conclusions: Increased risk perceptions are associated with adoption of behaviors preventing TBDs. Medical professionals play an important role in communicating knowledge about TBDs. There is a need to revise current communication strategies with respect to tick bites and prevention of LB and other TBDs.
Approach to Contemporary Risk Assessment, Prevention and Management of Thrombotic Complications in Multiple Myeloma

Simple Summary There is a significant risk of thrombotic complications in patients with multiple myeloma. Patient-related, disease-related, and treatment-related risk factors contribute to the observed prothrombotic environment. The prevention of thrombosis requires implementing risk assessment tools and pharmacological thromboprophylaxis. Newer oral anticoagulants are increasingly being used in this setting, but robust data emerging from controlled clinical trials are lacking. Despite the use of multiple myeloma-specific risk-assessment tools and the implementation of thromboprophylaxis based on current guidelines, the risk of thromboembolism remains significant, pointing to the need to understand this common complication further. Abstract Multiple myeloma (MM) is associated with an increased risk of thrombotic complications, which remains substantial despite the implementation of thromboprophylaxis. The procoagulant state that characterizes the disease is multifactorial, and a greater understanding of the underlying pathophysiology is required to inform appropriate thrombosis prevention. Currently, there is a shift towards using direct oral anticoagulants (DOACs) in this setting; head-to-head comparisons in the context of controlled clinical trials between class agents are still missing. MM-specific VTE risk assessment scores have been developed to optimize management and minimize the associated mortality/morbidity. Their clinical utility remains to be evaluated. The value of adding biomarkers to clinical scores to optimize their performance and increase their discriminatory power is also under assessment.
A Hybrid Robotic Network for Maritime Situational Awareness: Results From the INFORE22 Sea Trial

In this paper we describe an integrated system for maritime situational awareness (MSA) applications, built on a cooperative autonomous robotic network, and developed in the maritime use case of the INFORE EU H2020 project. INFORE project developed an interactive, real-time, extreme-scale analytics and forecasting system for handling and analysing massive streams of data. The MSA INFORE system exploits the synergy between global view (AIS data, ESA Sentinel satellite data), which provide contextual information over a wide area, and local view produced by a sensorised hybrid robotic network. Such a network was validated during the INFORE22 sea trial, held off the coast of Portovenere, Italy, in the Gulf of La Spezia, in February-March 2022. It was composed of a thermal camera and of two autonomous underwater vehicles (AUVs) equipped with passive sonars. The robots fused their measurements, and cooperatively adapted their navigation for localising a suspicious vessel, communicating her position to the MSA INFORE platform in real-time. For controlling the robots, we developed a perception layer, based on an occupancy grid map framework, which enabled the fusion of passive sonar bearing-only measurements for target localisation. The perception layer was also the basis for making cooperative decisions to adapt the network spatial configuration for improving mission performance. In this paper we report and discuss results from the INFORE22 trial. These results are one the first demonstrations of how data fusion and cooperative autonomy can increase the performance of a complex robotic network in a passive sonar surveillance mission in a real-world scenario. The INFORE MSA systems paves the way towards the development of complex, integrated MSA systems, which exploit robotic networks, characterised by advanced cooperative autonomy capabilities, for improving the local view picture, and for promptly reacting to the evolving scenario.
Rarefied gas flow simulation based on quasigasdynamic equations

The treatment of rarefied gas flows by means of equations based on the mechanics of continuum media is desirable because solving such equations requires less computational resources than methods based on a molecular description. The present work aims at clarifying the domain of validity of two continuum approaches by comparing their results to a reference given by a direct simulation Monte Carlo method. The first continuum approach is based on the usual Navier-Stokes (NS) equations. The second one is based on the quasigasdynamic (QGD) equations that are derived from the Boltzmann equation. The present paper includes a self-consistent presentation of QGD equations. The flow along a flat plate has been considered for a freestream Mach number varying from 1.5 to 20 and a wall temperature taken successively equal to freestream and stagnation temperatures. The results suggest that the QGD equations are superior to the NS ones. A criterion is proposed for the validity of the continuum approaches.
Relationship between the surface resistance and crystal orientation of YBa/sub 2/Cu/sub 3/O/sub 7-/spl delta// thin film

We have examined the relationship between in-plane orientation, grain size, fluctuation of grain axis and surface resistance of YBa/sub 2/Cu/sub 3/O/sub 7-/spl delta// (YBCO) films, The surface resistance of YBCO films with a mixture of [100] and [110] in-plane grains was larger than that of the films with perfect in-plane orientation. The behavior of surface resistance could be explained by the degree of grain boundaries of [100] and [110] in-plane orientation. The surface resistance of YBCO films was proportion to the fluctuation of grain axis. It was also proven that surface resistance of high-temperature superconductors is affected by the critical current.
Microlensing light curves: a new and efficient numerical method

When a source of constant luminosity moves behind a gravitational lens composed of compact objects, its flux is observed to change due to the varying amplification of the images produced by different components of the lens. A new method is presented to calculate such microlensed light curves for any given field of point masses. The method is sufficiently efficient and fast to allow one to calculate any desired statistical property of the light curves for a large number of models in a reasonable time, with present computers. We compare the light curves generated by this method with those produced by the ray-shooting method, and find good agreement
Intracranial aneurysm wall motion and wall shear stress from 4D computerized tomographic angiography images

It is widely accepted that wall shear stress is associated to aneurysm formation, growth and rupture. Early identification of potential risk factors may contribute to decide the treatment and improve patient care. Previous studies have shown associations between high aneurysm wall shear stress values and both elevated risk of rupture and regions of aneurysm growing. Based on the assumption that damaged regions of the endothelium have different mechanical properties, regions with differentiated wall displacement amplitudes are expected. A previous approach based on the analysis of bidimensional dynamic tomographic angiography had been designed to investigate those correlations, but its main limitation was that wall motion was measured in a selected plane. The purpose of this work is to overcome some of those limitations. High time and spatial resolution 4D computerized tomographic angiography images of cerebral aneurysms were acquired and analyzed in order to identify and characterize wall motion. Images were filtered and segmented at nineteen time points during the cardiac cycle and displacement was estimated within the aneurysm sac and compared to wall shear stress distributions from patient-specific unsteady finite element blood flow simulations.
Patents and R&D: is There a Lag?

This paper extends earlier work on the RID to patents relationship (Pakes-Griliches 1980, and Hausman, Hall, and Griliches,1984) to a larger but shorter panel of firms. The focus of the paper is on solving a number of econometric problems associated with the discreteness of the dependent variable and the shortness of the panel in the time dimension. We compare weighted nonlinear least squares as wellas Poisson-type models as solutions to the former problem. In attempting to estimate a lag structure on R&D in the absence of a sufficient history of the variable, we take two approaches: first, we use the conditional version of the negative binomial model, and second, we estimate the R&D variable itself as a low order stochastic process and use this information to control for unobserved R&D. R&D itself turns out to befairly well approximated by a random walk. Neither approach yields strong evidence of a long lag. The available sample, though numerically large, turns out not to be particularily informative on this question. It does reconfirm, however, a significant effect of R&D on patenting (with most of it occuring in the first year) and the presence of rather wide and semi-permanent differences among firms in their patenting policies.
Safety of Live Immunization in DiGeorge Syndrome: A Retrospective Single-Center Study in Korea, 2005–2021

Live immunization is contraindicated in patients with DiGeorge syndrome (DGS). We retrospectively investigated the occurrence of adverse events after live immunization in patients with DGS in Korea. The data of patients matching the International Classification of Disease-10 code of DGS (D82.1) at Severance Hospital Seoul, Korea, were extracted; patients without genetically diagnosed DGS were excluded. Based on T cell immunity status, the included patients were categorized into group A (CD3 < 500 or CD8 < 200 cells/mm3); group B (CD3 ≥ 500 and CD8 ≥ 200 cells/mm3); or group C (unknown). Among 94 patients, 38 (~40%, group A: 8 [21%]; group B: 30 [79%]) underwent immunological testing and 73 (~80%) received at least one live immunization (measles–mumps–rubella vaccination was most common [66/94, ~70%]). Fifty adverse events (fever [n = 29], upper respiratory infection [n = 9], diarrhea [n = 4], rash [n = 3], thrombocytopenia [n = 3], injection site pus [n = 1], and febrile convulsion [n = 1]) were observed; 13 (26%) occurred in group A, with no significant difference in incidence between groups A and B. Serious adverse events, including intensive care unit hospitalization or death, or diseases due to vaccine strains were not observed. In this study, live immunization was well tolerated by patients with partial DGS.
Aligning the seasonal migration of North Atlantic Right Whales with oceanic features

While baleen whales have been migrating through the oceans for millions of years, more recent human activity has heavily impacted their populations. The population of North Atlantic right whales (NARW) has been in rapid decline compared to other baleen whale species. To counteract this, there has been a recent push in science and conservation to understand how the ocean environment influences the behaviors of whales. The purpose of this study is to see how oceanic features factor in the migratory patterns North Atlantic right whales off the coast of New Jersey. The study was conducted in an offshore wind lease area off the south coast of New Jersey as part of the ECO-PAM Project. Autonomous vehicles equipped with oceanographic and ecological sensors simultaneously mapped whale detections in the context of physical ocean features. Results indicate that the presence of NARW begins near the New Jersey coast in late fall, transitions offshore in the winter, with no detections between mid-spring through mid-fall. Our findings indicate that there was no significant difference in observed temperature, salinity, oxygen concentration, density and chlorophyll in regions with and without NARWs. NARWs were found more often in the vicinity of strong cceanic fronts delineating regions of large gradients in ocean temperature and color. Analysis from the gliders, acoustics, and satellites highlights the potential for oceanic feature mapping to better understand NARW migration pathways and conduct mitigation strategies. This research serves as an example of the new insight gained when integrating concurrent oceanic and ecological data, and demonstrates how dynamic mapping through autonomous systems could support whale-friendly maritime activity in and around planned offshore wind lease areas in the Mid Atlantic Bight.