Miracle-dz/UniFAR-FTUs huggingface dataset:
A study of epidemiological factors in antenatal mothers with pregnancy-induced hypertension at the tertiary care hospital

Background: Pregnancy-induced hypertension (PIH) is one of the most common causes of both maternal and neonatal morbidity, affecting about 5%–8% of pregnant women. The risk factors postulated to influence the risk of PIH among the mothers include sociodemographic factors, genetic factors, pregnancy-related complications, or personal factors. Objectives: The objective of this study is to study the sociodemographic profile, prevalence, and epidemiological risk factors of PIH in antenatal patients. Materials and Methods: A cross-sectional study was conducted at GMC Latur, Maharashtra, India, as a part of postgraduation thesis work and was approved by MUHS Nashik. A total of 1600 antenatal care cases were selected. The study variables included mother's age, parity, height, body mass index, socioeconomic profile, and diet. Interviewer administered questionnaires were used to capture the demographic data and obstetric history. PIH prevalence in this study was found to be 6.06%. Primi-parity, age above 30 years, poor socioeconomic status, less education, joint family, >36 weeks of gestation, >5 g of salt intake, and moderate-to-severe anemia are some of the important epidemiological risk factors found to be associated with PIH. Conclusion: Pregnancy in later stages and primigravida's should be monitored carefully for PIH, and it should be prevented. Health education should be given about the consumption of iron tablets and iron rich food items to prevent anemia.
The synergistic effect of tranexamic acid and ethamsylate combination on blood loss in pediatric cardiac surgery

Background: Pediatric patients are at risk for bleeding after cardiac surgery. Administration of antifibrinolytic agents reduces postoperative blood loss. Objective: Evaluation of the efficacy of combined administration of tranexamic acid (TXA) and ethamsylate in the reduction of postoperative blood loss in pediatric cardiac surgery. Methods: This prospective randomized study included 126 children submitted for cardiac surgery, and they were allocated into three groups: control group (n = 42); TXA group (n = 42):- received only TXA; and combined ethamsylate TXA group (n = 42):- received a combination of TXA and ethamsylate. The main collected data included sternal closure time, the needs for intraoperative transfusion of blood and its products, the total amount of blood loss, and the amount of the whole blood and its products transfused to the patients in the first 24 postoperative hours. Results: Blood loss volume in the first 24 postoperative hours was significantly smaller in combined group than the TXA and control groups and was significantly smaller in the TXA group than the control group. The sternal closure time was significantly shorter in the combined group than the other 2 groups and significantly shorter in TXA than the control group. The amount of whole blood transfused to patients in the combined group during surgery and in the first postoperative 24 h was significantly smaller than the other 2 groups and smaller in TXA group than the control group during surgery. Conclusion: Combined administration of ethamsylate and TXA in pediatric cardiac surgery was more effective in reducing postoperative blood loss and whole blood transfusion requirements than the administration of TXA alone.
Synthesis, spectroscopic characterization, and biological activity studies of organotin(IV) derivatives of (E)-3-(3-fluorophenyl)-2-phenyl-2-propenoic acid. Crystal and molecular structure of Et2Sn[OCOC(C6H5)CH(3-FC6H4)]

The complexes Me2SnL2 (I), Me3SnL (II), Et2SnL2 (III), n-Bu2SnL2 (IV), n-Bu3SnL (V), n-Oct2SnL2 (VI), Bz2SnL2 (VII), and Ph3SnL (VIII), where “L” is (E)-3-(3-fluorophenyl)-2-phenyl-2-propenoate, have been prepared and structurally characterized by means of elemental analysis, infrared, mass, and multinuclear (1H, 13C, 119Sn) NMR spectral techniques. The spectroscopic results showed that the geometry around the Sn atom in triorganotin(IV) derivatives is four-coordinated in noncoordinating solvent and behaves as five-coordinated linear polymers with bridging carboxylate groups or five-coordinated monomers, both acquiring trans-R3SnO2 geometry for Sn in the solid state. While all the diorganotin(IV) derivatives may acquire trigonal bipyramidal structures in solution due to collapse of the SnOCO interaction and octahedral geometries in the solid state, which have been confirmed by the X-ray crystallographic data of the compound III. The crystal structure of Et2SnL2 (III) has been determined by X-ray crystallography and is found skew-trapezoidal bipyramidal, which substantiates that the ligand acts as an anisobidentate chelating agent, thus rendering the Sn atom six coordinated. The crystal is monoclinic with space group C21/n. All the investigated compounds have also been screened for biocidal and cytotoxicity data. © 2006 Wiley Periodicals, Inc. Heteroatom Chem 17:420–432, 2006; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20243
Intravenous colistin in the treatment of multidrug-resistant gram-negative organism in tertiary hospital, Jazan, KSA

Background: It was considered that the resistance of drugs such as carbapenems and cephalosporins against severe or high risk gram-negative bacteria became a tremendous confront. This might be attributed to the little amount of these drugs to be used against the multi-resistant bacteria (MRB). Therefore, Colistin, Fosfomycin, Temocillin, and Rifampicin are antibiotics that have been used as multidrug-resistant bacterial infections in the treatment of some species of bacteria such as Acinetobacter, Pseudomonas species, and Enterobacteriaceae. Aim: the present study is aimed to assess the integrity and efficiency of colistin for treating of the multidrug-resistant bacteria (MDR) especially gram-negative one among critical and non-critical patients in tertiary hospital in Jazan city. Ninety four patients who met the selection criteria and received colistimethate sodium (colistin) in the period between Februarys 2017 and March 2018 were recruited and their charts were reviewed retrospectively. Patients' information, medical conditions, and laboratory data were extracted. All patients received IV colistin, and the majority of the patients showed in their culture reports multidrug-resistant bacteria such as Pseudomonas aeruginosa and Acinetobacter baumannii. Patients who had normal renal function received from 2.5 to 5.0 mg of colistin/kg, which was divided in two or three doses intravenously, for duration ranging between 10 and 14 days. Results and conclusion: Approximately half of patients (48.93%) were fully recovered, while 19% of them were partially responded to colistin treatment. In the current study it was showed that IV colistin treatment against the multidrug-resistant bacteria (gram-negative bacteria) was strongly related to mild nephrotoxicity in addition to with a proper response as shown only in three of our patients
Long‐term clinical outcome and mortality risks after paclitaxel‐coated balloon angioplasty in patients with peripheral artery disease: An observational clinical study

Drug‐eluting devices (DEDs) are usually used as a standard therapy for revascularization in femoropopliteal artery disease. Randomized controlled trails have found that DEDs with paclitaxel result in superior patency rates and decreased target lesion revascularization. A meta‐analysis by Katsanos et al indicated an increased long‐term mortality in patients treated with paclitaxel‐coated devices. The aim of this observational clinical study was to assess the long‐term clinical outcomes and mortality risk after paclitaxel‐coated balloon angioplasty in patients with symptomatic peripheral artery disease.
CON: Pulmonary artery catheter use should be forgone in modern clinical practice

The pulmonary artery catheter (PAC) and its role in the practice of modern medicine remains to be questioned and has experienced a substantial decline in its use in the most recent decades. The complications associated to its use, the lack of consistency of the interpretation provided by the PAC among clinicians, the development of new hemodynamic methods, and the deleterious cost profile associated to the PAC are some of the reasons behind the decrease in its use. Since its introduction into clinical practice, the PAC and the data obtained from its use became paramount in the management of critically ill patients as well as for the high-risk/invasive procedures. Initially, many clinicians were under the impression that regardless the clinical setting, acquiring the information provided by the PAC justified its use, until a growing body of evidence demonstrated its lack of mortality and morbidity improvement, as well as several reports of the presence of difficulties—some of them fatal—during its insertion. The authors present an updated review discussing the futility of the PAC in current clinical practice, the complications associated to its insertion, the lack of mortality benefit in critically ill patients and cardiac surgery, as well as present alternative hemodynamic methods to the PAC.
A randomized clinical study to compare implant stability and bone loss using early loading protocol in two implant systems with different design

Aims: The study compared changes in implant stability and bone loss of implants with different designs using early loading at 6 weeks. Setting and Design: In vivo-comparative study. Materials and Methods: Forty subjects were selected and divided randomly by sealed envelope method in Group X and Group A for early loading for missing single posterior tooth in mandible. Implants in Group X had flared crest module and buttress thread design, whereas implants in Group A had parallel crest module and V-shaped thread design. All subjects were evaluated by Ostell for implant stability at the interval of baseline, 6 weeks, 3 months, and 6 months. ImageJ software was used for measurement of crestal bone loss in intraoral periapical radiographs at the interval of 6 weeks, 3 months, and 6 months. Statistical Analysis Used: Unpaired t test, repeated ANOVA, Tukey post hoc test. Results: The mean bone loss values of Group X at predetermined interval were 1.51 ± 0.20 mm, 2.11 ± 0.21 mm and 2.13 ± 0.21 mm. The mean bone loss values of Group A were 1.79 ± 0.16 mm, 2.92 ± 0.23 mm and 2.95 ± 0.23 mm. The mean bone loss was statistical significant (P < 0.05) at 6 weeks, 3 months and 6 months. It was highly significant in Group A at 6 months (P < 0.001). Conclusions: It was concluded that Group X implants design showed better implant stability and less bone loss when compared to Group A implants design.
A study on smartphone addiction and its effects on sleep quality among nursing students in a municipality town of West Bengal

Background: Smartphones are now an important gadget for us, but the many are getting addicted to it. Researchers showed that smartphone addiction and late-night usage affects sleep quality. Indian nurses are already facing a heavy burden of depression and present position of nurses is quite insecure. Very few studies were performed over nursing students and that leads to the selection of this topic for my research. Methodology: It was a cross-sectional, observational, and questionnaire-based study, performed over B.Sc. Nursing students of University College of Nursing, WBUHS. The questionnaire has three parts. The first part was for sociodemographic variables, the second part measures the addictive phenomena associated with smartphone overuse using a Smartphone Addiction Scale (SAS), the last part was intended to measure the sleep quality by using Pittsburgh Sleep Quality Index (PSQI). Collected data was compiled and analyzed with the help of MS-Excel from Microsoft Office Package-2016. Results: Out of 91 students, 46 students were found to be not addicted, while 45 were addicted to smartphone, as measured by SAS. On PSQI, 17.58% students were found to be good sleepers, while 82.42% came out to be poor sleepers. Significant association was found between age and smartphone addiction (p=0.000031) and between daily calls and sleep quality (p=0.025333). Conclusion: It can be finally concluded that increase in smartphone usage is now a serious matter of concern and lower age groups are more susceptible towards it. Broad-spectrum studies involving multiple institutions is needed to reveal the bigger picture
Clinical Features and Outcomes of Neuropsychiatric Systemic Lupus Erythematosus in China

Objective To identify the clinical characteristics, magnetic resonance imaging (MRI) results, and prognostic factors of neuropsychiatric (NP) systemic lupus erythematosus (SLE; NPSLE) in a relatively large patient series in China. Methods Data of patients with NPSLE at Peking Union Medical College Hospital (PUMCH) were collected retrospectively from June 2012 to June 2016. NPSLE patients were compared with 220 non-NPSLE patients. Survival rates were evaluated using the Kaplan-Meier curves, log-rank test, and Cox proportional hazards modeling. Cranial MRI results were also studied. Results Of the 194 included patients, sixteen subtypes of NPSLE were identified, and the most common manifestations were seizure (36.6%), acute confusional state (25.3%), and cerebral vascular disease (15.5%). Compared with the non-NPSLE group, NPSLE patients were significantly more likely to have typical lupus symptoms, higher Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI-2K) scores (P = 0.002), and positive rate of anti-ribosomal P protein antibodies (P = 0.008). Patients with seizure were more likely to have higher SLEDAI-2K scores and positive anti-β2GP1 than non-NPSLE patients. Sixteen patients died during follow-up. The most common cause of death was infection (37.5%). NPSLE significantly decreased survival rates of SLE patients. Patients with elevated serum creatinine (P = 0.001), hypocomplementemia (P = 0.031), and SLEDAI − 2K scores ≥ 15 (P = 0.014) had shorter survival periods. Eighty-two patients underwent detailed cranial MRI analysis; of these, 50 (61.0%) had abnormal results. Small vessel disease was the most common abnormal finding, followed by inflammatory-like lesions and large vessel disease. Conclusions High disease activity and positive rate of anti-ribosomal P protein antibodies may be risk factors for NPSLE. NPSLE decreases survival rates of SLE patients. Renal insufficiency and high disease activity are predictive of poor prognoses for NPSLE patients.
Assessment of Clinical Leadership Training Needs in Senior Pediatric Residents

Introduction: Although clinical leadership in physicians is associated with improved healthcare, leadership training is rarely integrated into residency training. Our objective was to perform a comprehensive needs assessment of our pediatric residents’ existing leadership experiences and knowledge and to identify training gaps within our program. Methods: First, we held focus groups with senior pediatric residents to understand their clinical leadership experiences and identify training needs. Notes were transcribed and independently coded by 2 researchers, with thematic saturation achieved. Next, we focused each session on 1 leadership content area identified from the aforementioned themes to better understand the specific training needs for each topic. Results: Four major themes were identified: (1) Effective and timely communication with supervisors, learners, ancillary staff, and patients is indispensable in promoting safe patient care, avoiding conflict, and preventing misunderstanding. (2) Training in teaching methods is desired, especially gaining the skills needed to teach various levels of learners, in different settings and under time constraints. (3) Time management, availability of resources, and team logistics were often learned through trial-and-error. (4) Self-care, self-acceptance, emotional regulation, and peer debriefing are relied upon to manage negative emotions; rarely are resilience and wellness strategies employed in “real-time. ” Conclusion: Senior residents currently face gaps in clinical leadership training and may benefit from additional instruction in content areas related to these 4 themes. Our next steps are to utilize the identified themes to develop a longitudinal and skills-based clinical leadership curriculum to address the gap in graduate medical education.
COVID-19 and Menstrual Status: Is Menopause an Independent Risk Factor for SARS Cov-2?

Background: COVID-19 has shown a definite association with gender, a predilection for males in terms of morbidity and mortality. The indirect evidence of the protective effect of estrogen has been shown by Channappanavar, in the animal model and Ding T. in a multihospital study from China, suggesting menopause as independent risk factor and estrogen is negatively correlated with severity. Objective: Study the clinical profile and outcomes in premenopausal and menopausal. Covid-19-infected women and analyzed the effect of menstrual status on the outcome. Materials and Methods: A retrospective cohort study conducted on 147 mild and moderate category COVID-19 females admitted between May and August 2020 using hospital records and telephonic follow-up. Two groups formed based on menstrual status: group-1 (premenopausal/estrogenic) and Group-2 (menopausal/hypoestrogenic). Hospital stay duration was considered as primary, while the category of disease on admission, clinical course, the requirement of oxygen, and mortality and residual symptoms were taken as a secondary outcome to compare the groups. Results: Overall Group-1 had significantly more of mild disease, while Group-2 had moderate cases (39 [76.5%] vs. 14 [14.6%] P < 0.01). Menopausal group has significantly more requirement of oxygen (32 [62.7%] vs. 20 [20.8%]), ventilation (14 [27.5%] vs. 1 [1%]) progression-to-severe disease (23.5% vs. 7.3%) and prolonged hospital stay ([14.1 ± 8.9 vs. 8.6 ± 3.9 days] P < 0.01). However, multivariate logistic regression failed to show a significant association between hospital stay and progression with menopause. Ferritin and residual symptoms found significantly higher in menopausal. Conclusions: No definite association was found between menopause and COVID-19 outcome with hospital stay duration or disease progression in our study.
A cross-sectional study to assess acute malnutrition among under-5 children in the field practise area of a teaching hospital in Chennai

Context: Malnutrition is one of the leading problem mainly in childhood, affecting growth and development especially under 5 years of age. According to NFHS-4, under-5 children about 27% are stunted, 20% are wasted and 24% are underweight. Determining acute malnutrition (wasting) and its factors is necessary to prevent complications. Aims: To assess acute malnutrition among under 5 years children and determine associated factors responsible. Settings and Design: Cross-sectional study done at field practice area under a teaching hospital in Chennai. Materials and Methods: Totally, 149 children under 5 years of age were selected and assessed for acute malnutrition using WHO standards (Z-scoring) by calculating weight for height. Questionnaire for checking associated factors was used. Statistical Analysis Used: Data were entered in excel spreadsheet and analyzed using SPSS software version 16 and for inferential statistical analysis was done using Chi square test. Result: Among the study population, 87.2% children were normal, 10% of children had wasting (below -2 S.D.) and 2.8% of children had severe wasting (below -3 S.D.). Wasting was also prevalent among people of low socioeconomic class and was maximum in children of age group 1-3 years. Low birth weight, absence of exclusive breast feeding and complementary feeding practices, partial immunization and other illnesses also had effect, leading to acute malnutrition. Conclusion: Level of acute malnutrition in the field practice area is lesser than the national average and determines few factors associated with malnutrition among under – 5 children.
New data on rasvumite and djerfisherite

Electron microprobe analyses and X-ray diffraction studies have shown the identity of rasvumite from a new occurrence at Coyote Peak, Humboldt County, California, and holotype material from the Khibina massi-f, Kola Peninsula, USSR. The electron microprobe analyses have established that the correct formula is KFe2S3 instead of K3FeeS,a, as originally proposed. We compare new electron microprobe analyses of djerfisherite from the two localities and show that these djerflsherites do not contain magneslum.
Pharmacognostic evaluation of aerial parts of Euphorbia tirucalli

Objectives: This study aimed to establish the pharmacognostic profile of aerial parts of Euphorbia tirucalli (ET) as per World Health Organization guidelines for ensuring the quality and identification of adulteration. Materials and Methods: Standardization parameters such as macroscopic and microscopic characteristics of the study plant were evaluated. Hydroalcoholic and ethyl acetate extracts were prepared and subjected to preliminary phytochemical screening. Further, the extracts were used to analyze total phenol and flavonoid contents, and their antioxidant activities were estimated using 2,2-diphenyl-1-picrylhydrazyl (DPPH) and nitric oxide assay. Results: Shape, size, color, odor, surface characteristics, and microscopic images exhibited useful diagnostic characteristics of aerial parts of plants. Total ash, water-soluble, and acid-insoluble ash were found to be 16.65' ± 1.050', 5.623' ± 1.11', and 2.56' ± 0.706, respectively. The loss on drying was 9.6', and water and alcoholic extractive values were 4.0' and 26', respectively. Phytochemical screening revealed the presence of saponins, steroidal triterpenoids, phenols, and flavonoids. Total flavanoid and phenol content in hydroalcoholic and ethyl acetate extracts of ET was found to be 246 mg rut/g, 120 mg rut/g, 81.36 mg gallic acid equivalent (GAE)/g, and 279.58 mg GAE/g respectively. 2,2-diphenyl-1-picrylhydrazyl and nitric oxide scavenging assay revealed the IC50 values of hydroalcoholic and ethyl acetate extracts as 69.599 μg/ml, 20.454 μg/ml, 17.017 μg/ml, and 17.562, respectively. Conclusion: The findings obtained from the present study help to authenticate and establish the pharmacopeia standards for the ET plant.
Quality of life (QOL) among older persons in an urban and rural area of Bangalore, South India

Introduction: The increasing ageing population of India has unique challenges due to changing social structure, health issues and inaccessible healthcare facilities. These challenges can adversely affect the quality of life (QOL) of older persons. Hence, this study was undertaken with the objective of assessing the QOL among older persons in an urban and rural area of Bangalore. Materials and Methods: Cross-sectional study was done among 977 older persons 60 years and above. Census enumeration blocks in urban areas and villages in rural areas were randomly selected and all older persons meeting the inclusion criteria were administered the WHOQOL-Bref questionnaire. Results: Mean QOL scores (SD) in the physical, psychological, social relationship and environmental domains were 50.5 (5.5), 49.2 (5.5), 49.4 (6.5) and 49.3 (5.1) in rural areas and 57.4 (8.9), 58.6 (8.8), 64.6 (10.8) and 60.0 (9.4) in urban areas, respectively. Compared to urban, rural older persons uniformly have lower QOL irrespective of sex, education or financial dependence. Conclusion: Inequitable health resource distribution and inadequate social support systems must be addressed to improve the QOL of older persons, especially in rural areas. Primary care providing essential services can bridge this urban–rural divide and improve QOL of older persons.