Miracle-dz/UniFAR-FTUs huggingface dataset:
Morphological Variability and Storage Root Productivity of Some Sweet Potato (Ipomoea Batatas (L.) Lam) Genotypes in An Ultisol

Ten sweet potato (Ipomoea batatas (L.) Lam) genotypes sourced from National Root Crops Research Institute, Umudike were evaluated under rainfed condition in 2020 and 2021 cropping seasons at the Teaching and Research Farm of the University of Uyo, Uyo, Akwa Ibom State to ascertain variability among ten sweet potato genotypes and identify traits which are positively and significantly associated with yield and also identify genotypes with high yield potential for cultivation on an ultisol of Akwa Ibom State, Nigeria. The ten genotypes: TIS87/0087, Naspoy-12, Umuspo-4, Umuspo-1, Naspoy-11, Lourdes, Erica, Delvia, Ex-Igbariam and Umuspo-3 were used as treatments and the experiment was laid out in a randomized complete block design with three replications. Data collected were subjected to analysis of variance, correlation and principal component analysis. The genotype differs significantly (P≤ 0.05) for number of marketable roots, weight of marketable roots and fresh roots yield. UMUSPO-3 was superior over all the other genotypes for the following character; number of marketable roots, weight of marketable root yield and fresh root yield. Umuspo-3 produced the highest storage root yield (28.78t/ha, 27.09t/ha) in 2020 and 2021 cropping seasons, respectively. The result of the correlation analysis also revealed that vine length, number of marketable roots, weight of marketable were highly significantly and positively (P<0.01) correlated with fresh root yield. Principal component analysis (PCA) had four main principal components explaining 81.55% of the total variation with number of marketable roots, weight of marketable tuber and storage root yield contributing the most to the first PCA. Umuspo-3 outperformed the other nine sweet potato genotypes in yield and yield related characters. Therefore, Umuspo-3 been a high yielding genotype adaptable to Uyo agro-ecology, could be recommended to sweet potato growers for fresh storage root production.
The Evolving Role of External Forcing in North Atlantic SST Variability Over the Last Millennium

Atlantic Multidecadal Variability (AMV) impacts temperature, precipitation, and extreme events on both sides of the Atlantic basin. Previous studies with climate models have suggested that when external radiative forcing is held constant, the large-scale ocean and atmosphere circulation are associated with sea-surface temperature anomalies that have similar characteristics to the observed AMV. However, there is an active debate as to whether these internal fluctuations driven by coupled atmosphere-ocean variability remain influential to the AMV on multidecadal timescales in our modern, anthropogenically-forced climate. Here we provide evidence from multiple large ensembles of climate models, paleo reconstructions, and instrumental observations of a growing role for external forcing in the AMV. Prior to 1850, external forcing, primarily from volcanoes, explains about one third of AMV variance. Between 1850 and 1950, there is a transitional period, where external forcing explains half of AMV variance, but volcanic forcing only accounts for about 10% of that. After 1950, external forcing explains three quarters of AMV variance. That is, the role for external forcing in the AMV grows as the variations in external forcing grow, even if the forcing is from different sources. When forcing is relatively stable, as in earlier modeling studies, a higher percentage of AMV variations are internally generated.
Juvenile Polyps in Bangladeshi Children and Their Association with Fecal Calprotectin as a Biomarker

Purpose Colonoscopy is considered the most reliable method for the diagnosis of juvenile polyps. However, colonoscopic screening is an invasive and expensive procedure. Fecal calprotectin (FCP), a marker of intestinal inflammation, has been shown to be elevated in patients with polyps. Therefore, this study aimed to evaluate FCP as a screening biomarker for the diagnosis of juvenile polyps. Methods This cross-sectional, observational study was conducted at the Pediatric Gastroenterology and Nutrition Department, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh. For children with polyps, colonoscopic polypectomy and histopathology were performed. FCP levels were analyzed before and 4 weeks after polypectomy in all patients. Information was recorded in a datasheet and analyzed using the computer-based program SPSS. Results The age of the children was between 2.5 and 12 years. Approximately 93% of the polyps were found in the rectosigmoid region. Children with juvenile polyps had elevated levels of FCP before polypectomy that subsequently normalized after polypectomy. The mean FCP levels before and after polypectomy were 277±247 µg/g (range, 80–1,000 µg/g) and 48.57±38.23 µg/g (range, 29–140 µg/g) (p<0.001), respectively. The FCP levels were significantly higher in patients with multiple polyps than in those with single polyps. Moreover, mean FCP levels in patients with single and multiple polyps were 207.6±172.4 µg/ g and 515.4±320.5 µg/g (p<0.001), respectively. Conclusion Colonic juvenile polyps were found to be associated with elevated levels of FCP that normalized after polypectomy. Therefore, FCP may be recommended as a noninvasive screening biomarker for diagnosis of colonic juvenile polyps.
Fueling Organized Crime: The Mexican War on Drugs and Oil Thefts

We show that the War on Drugs launched by the Mexican President Felipe Calderón in 2007 pushed drug cartels into large-scale oil thefts. Municipalities that the presidential candidate’s party barely won at the local elections in 2007-2009 exhibit a larger increase in illegal oil taps over the following years, compared to municipalities in which the presidential candidate’s party barely lost the elections. Challenger cartels in the drug market leapfrog incumbent drug cartels when entering the new illegal activity, analogous to what is typically observed in legal markets. Since challengers and incumbents specialize in diﬀerent criminal sectors, the expansion of challengers does not increase violence in municipalities traversed by oil pipelines. At the same time, the municipalities traversed by a pipeline witness a decrease in schooling rates. PAN candidates who succeeded in the ﬁrst mayoral elections held after the start of the War on Drugs (2007-2009) favored the coordination of the crackdown on narcotics at the local level. Therefore, she estimates the eﬀect of government crackdowns on drug-related violence and drug-traﬃcking routes by comparing municipalities in which PAN candidates won or lost by a narrow margin. Using the same Regression Discontinuity (RD) design within the sub-sample of municipalities traversed by oil pipelines, we show that municipalities in which the PAN candidate won a local election by a narrow margin in 2007-2009 had more taps over the following period, 2007-2014, compared to municipalities in which the PAN candidate lost by a narrow margin. This suggests that the drug crackdown pushed cartels already active within a municipality towards the new busi-1
Lupins and Health Outcomes: A Systematic Literature Review

Lupins have a unique nutrient profile among legumes and may have beneficial health effects when included in the diet. The aim of this systematic review was to investigate the effects of lupin on a range of health outcome measures. Databases included MEDLINE, Embase and CINAHL, and focused on controlled intervention studies on healthy adults and those with chronic disease such as type 2 diabetes, cardiovascular disease and overweight. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses protocol was followed. Investigated intervention diets utilised whole lupin, lupin protein or lupin fibre, and outcomes were measured by markers of chronic disease, body weight and satiety. Quality assessment of results was performed using the Cochrane revised risk of bias tool. Overall, 21 studies with 998 participants were included: 12 using whole lupin, four used lupin protein and five lupin fibre. Beneficial changes were observed in 71% of studies that measured blood pressure, 83% measuring satiety and 64% measuring serum lipids. Unintended weight loss occurred in 25% of studies. Whole lupin demonstrated more consistent beneficial effects for satiety, glycaemic control and blood pressure than lupin protein or lupin fibre. Heterogeneity, low study numbers and a small participant base indicated further studies are required to strengthen current evidence particularly regarding the protein and dietary fibre components of lupin.
Structure and Function of the ABCD1 Variant Database: 20 Years, 940 Pathogenic Variants, and 3400 Cases of Adrenoleukodystrophy

The progressive neurometabolic disorder X-linked adrenoleukodystrophy (ALD) is caused by pathogenic variants in the ABCD1 gene, which encodes the peroxisomal ATP-binding transporter for very-long-chain fatty acids. The clinical spectrum of ALD includes adrenal insufficiency, myelopathy, and/or leukodystrophy. A complicating factor in disease management is the absence of a genotype–phenotype correlation in ALD. Since 1999, most ABCD1 (likely) pathogenic and benign variants have been reported in the ABCD1 Variant Database. In 2017, following the expansion of ALD newborn screening, the database was rebuilt. To add an additional level of confidence with respect to pathogenicity, for each variant, it now also reports the number of cases identified and, where available, experimental data supporting the pathogenicity of the variant. The website also provides information on a number of ALD-related topics in several languages. Here, we provide an updated analysis of the known variants in ABCD1. The order of pathogenic variant frequency, overall clustering of disease-causing variants in exons 1–2 (transmembrane domain spanning region) and 6–9 (ATP-binding domain), and the most commonly reported pathogenic variant p.Gln472Argfs*83 in exon 5 are consistent with the initial reports of the mutation database. Novel insights include nonrandom clustering of high-density missense variant hotspots within exons 1, 2, 6, 8, and 9. Perhaps more importantly, we illustrate the importance of collaboration and utility of the database as a scientific, clinical, and ALD-community-wide resource.
The Development of a Green Innovative Bioactive Film for Industrial Application as a New Emerging Technology to Protect the Quality of Fruits

Today, the most significant challenge encountered by food manufacturers is degradation in the food quality during storage, which is countered by expensive packing, which causes enormous monetary and environmental costs. Edible packaging is a potential alternative for protecting food quality and improving shelf life by delaying microbial growth and providing moisture and gas barrier properties. For the first time, the current article reports the preparation of the new films from Ditriterpenoids and Secomeliacins isolated from Melia azedarach (Dharek) Azadirachta indica plants to protect the quality of fruits. After evaluating these films, their mechanical, specific respirational, coating crystal elongation, elastic, water vapor transmission rate (WVTR), film thickness, and nanoindentation test properties are applied to apple fruit for several storage periods: 0, 3, 6, 9 days. The fruits were evaluated for postharvest quality by screening several essential phytochemical, physiological responses under film coating and storage conditions. It was observed that prepared films were highly active during storage periods. Coated fruits showed improved quality due to the protection of the film, which lowered the transmission rate and enhanced the diffusion rate, followed by an increase in the shelf life. The coating crystals were higher in Film-5 and lower activity in untreated films. It was observed that the application of films through dipping was a simple technique at a laboratory scale, whereas extrusion and spraying were preferred on a commercial scale. The phytochemicals screening of treated fruits during the storage period showed that a maximum of eight important bioactive compounds were present in fruits after the treatment of films. It was resolved that new active films (1–5) were helpful in the effective maintenance of fruit quality and all essential compounds during storage periods. It was concluded that these films could be helpful for fruits growers and the processing industry to maintain fruit quality during the storage period as a new emerging technology.
Graft Fibrosis Over 10 to 15 Years in Pediatric Liver Transplant Recipients: Multicenter Study of Paired, Longitudinal Surveillance Biopsies

Previous single‐center, cross‐sectional studies have reported a steep increase in the prevalence and severity of fibrosis through 10 to 15 years after pediatric liver transplantation. We report a multicenter study of paired surveillance biopsies in a contemporary cohort. Children who underwent liver transplant when younger than 6 years old and had paired surveillance liver biopsies were enrolled (n = 78, 35% girls, median 1.2 years old at transplant). A central pathologist graded inflammation, assessed rejection activity index, and staged fibrosis in the portal, sinusoidal, and perivenular compartments, allowing for calculation of the Liver Allograft Fibrosis Score (LAFSc). Analysis of variance tested associations between fibrosis progression and clinical parameters. The first biopsy, at a median 8.2 years (interquartile range, 5.9‐11.6 years) after transplantation, showed absent to mild fibrosis (LAFSc 0‐2) in 29%, moderate (LAFSc 3‐5) in 56%, and severe (LAFSc 6‐7) in 14% of patients. The second biopsy, at a median 4.7 years (IQR, 4.3‐5.1 years) later, showed fibrosis progression (LAFSc increased by ≥3) in 10 (13%) and regression (LAFSc decreased by ≥3) in 4 (5%) patients. After adjusting for baseline LAFSc, younger age at transplant was the only risk factor for fibrosis progression. Although fibrosis prevalence and severity 6 to 12 years after transplant was similar to previous reports, fibrosis trajectory during the next 4 to 5 years was stable. Our data may be reassuring for children with consistently normal liver tests. A comprehensive understanding of factors determining allograft health during the very long term is essential to optimizing allograft and patient health.
Flourishing in the Workplace: A One-Year Prospective Study on the Effects of Perceived Organizational Support and Psychological Capital

People working in urban areas often experience various work-related stressors, such as long working hours, high work pressure, and work-life interference, which can lead to severe mental and physical consequences. Identification of the protective factors that enable employees to flourish and thrive is especially important. The present study aims to identify the organizational and personal resources that contribute to employee flourishing. Adopting the conservation of resources theory and organizational support theory, it was hypothesized that perceived organizational support (POS) would promote employee flourishing through increasing psychological capital (PsyCap). A prospective study was conducted on a sample of 400 working adults from the social and personal services industry in Hong Kong. Data were collected at baseline, three months, and one year. Both Diener’s composite model of flourishing and Seligman’s PERMA model of flourishing were tested. Structural equation modeling showed that PsyCap at three months significantly mediated the effects of POS at baseline on flourishing and all dimensions of PERMA (positive emotion, engagement, relationships, meaning, accomplishments) at one year. Findings suggest that PsyCap underlies the process through which POS influences flourishing, whereby the promotion of positive psychological resources in a nurturing and supportive organization contributes to psychosocial functioning in the long run.
Glucose-Lowering Medications and Post-Dementia Survival in Patients with Diabetes and Dementia

Background: The effectiveness of glucose-lowering drugs (GLDs) is unknown among patients with dementia. Objective: To analyze all-cause mortality among users of six GLDs in dementia and dementia-free subjects, respectively. Methods: This was a longitudinal open-cohort registry-based study using data from the Swedish Dementia Registry, Total Population Register, and four supplemental registers providing data on dementia status, drug usage, confounders, and mortality. The cohort comprised 132,402 subjects with diabetes at baseline, of which 11,401 (8.6%) had dementia and 121,001 (91.4%) were dementia-free. Subsequently, comparable dementia – dementia-free pairs were sampled. Then, as-treated and intention-to-treat exposures to metformin, insulin, sulfonylurea, dipeptidyl-peptidase-4 inhibitors, glucagon-like peptide-1 analogues (GLP-1a), and sodium-glucose cotransporter-2 inhibitors (SGLT-2i) were analyzed in the parallel dementia and dementia-free cohorts. Confounding was addressed using inverse-probability weighting and propensity-score matching, and flexible parametric survival models were used to produce hazard ratios (HR) and 95% confidence intervals (CI) of the association between GLDs and all-cause mortality. Results: In the as-treated models, increased mortality was observed among insulin users with dementia (HR 1.34 [95%CI 1.24–1.45]) as well as in dementia-free subjects (1.54 [1.10–1.55]). Conversely, sulfonylurea was associated with higher mortality only in dementia subjects (1.19 [1.01–1.42]). GLP-1a (0.44 [0.25–0.78]) and SGLT-2i users with dementia (0.43 [0.23–0.80]) experienced lower mortality compared to non-users. Conclusion: Insulin and sulfonylurea carried higher mortality risk among dementia patients, while GLP-1a and SGLT-2i were associated with lower risk. GLD-associated mortality varied between dementia and comparable dementia-free subjects. Further studies are needed to optimize GLD use in dementia patients.
Extracellular vesicle‐mediated delivery of circDYM alleviates CUS‐induced depressive‐like behaviours

Abstract Major depressive disorder (MDD) is the most prevalent psychiatric disorder worldwide and severely limits psychosocial function and quality of life, but no effective medication is currently available. Circular RNAs (circRNAs) have been revealed to participate in the MDD pathological process. Targeted delivery of circRNAs without blood‐brain barrier (BBB) restriction for remission of MDD represents a promising approach for antidepressant therapy. In this study, RVG‐circDYM‐extracellular vesicles (RVG‐circDYM‐EVs) were engineered to target and preferentially transfer circDYM to the brain, and the effect on the pathological process in a chronic unpredictable stress (CUS) mouse model of depression was investigated. The results showed that RVG‐circDYM‐EVs were successfully purified by ultracentrifugation from overexpressed circDYM HEK 293T cells, and the characterization of RVG‐circDYM‐EVs was successfully demonstrated in terms of size, morphology and specific markers. Beyond demonstrating proof‐of‐concept for an RNA drug delivery technology, we observed that systemic administration of RVG‐circDYM‐EVs efficiently delivered circDYM to the brain, and alleviated CUS‐induced depressive‐like behaviours, and we discovered that RVG‐circDYM‐EVs notably inhibited microglial activation, BBB leakiness and peripheral immune cells infiltration, and attenuated astrocyte disfunction induced by CUS. CircDYM can bind mechanistically to the transcription factor TAF1 (TATA‐box binding protein associated factor 1), resulting in the decreased expression of its downstream target genes with consequently suppressed neuroinflammation. Taken together, our findings suggest that extracellular vesicle‐mediated delivery of circDYM is effective for MDD treatment and promising for clinical applications.
Intrinsic Exploration as Empowerment in a Richly Structured Online Game

Studies of human exploration frequently cast people as serendipitously stumbling upon good options. Yet these studies may not capture the richness of exploration strategies that people exhibit in more complex environments. We study human behavior in a large data set of 29,493 players of the richly-structured online game "Little Alchemy 2''. In this game, players start with four elements, which they can combine to create up to 720 complex objects. We find that players are driven to create objects that empower them to create even more objects. We find that this drive for empowerment is eliminated when people play a version of the game that lacks recognizable semantics, indicating that they use their knowledge about the world to guide their exploration. Our results suggest that the drive for empowerment may be a potent source of intrinsic motivation in richly structured domains, particularly those that lack explicit reward signals.
Efficacy and Safety of Novel Aspirin Formulations: A Randomized, Double-Blind, Placebo-Controlled Study

Low-dose aspirin represents the best option in the secondary prevention of coronary artery disease, but its extensive use in primary prevention is limited by the occurrence of gastric mucosal lesions and increased risk of bleeding. We investigated the safety profile of a novel sublingual aspirin formulation in 200 healthy volunteers, randomly assigned to ten (n = 20 each) different 7-day once-daily treatment regimens. Gastric mucosal injury based on the modified Lanza score (MLS), the histopathology of gastric mucosa and the serum determination of thromboxane B2 (TXB2) and urinary 11-dehydro-TXB2 levels were evaluated at basal as well as after 7 days of each placebo or aspirin treatment regimen. In Groups A and B (placebo—oral and sublingual, respectively), no changes in MLS and in gastric mucosal micro-vessel diameter were found at day 7. In contrast, in Groups C and D (oral standard aspirin—100 and 50 mg daily, respectively), the median MLS was significantly increased. Very few changes were found in Groups E and F (standard sublingual aspirin—100 and 50 mg, respectively). Groups G and H (oral administration of micronized collagen-cogrinded aspirin) showed gastric protection compared to Groups C and D. Moreover, Groups I and L (sublingual collagen-cogrinded aspirin—100 and 50 mg, respectively) showed a significant reduction (Group I) or total abolition (Group L) of gastric mucosal lesions and no difference compared to the standard one in serum TXB2 and urinary 11-dehydro-TXB2 levels. In conclusion, our data show that the new formulation leads to a better safety profile compared to standard aspirin, representing a better therapeutic option for extended use in primary and secondary prevention of cardiovascular diseases.