Miracle-dz/UniFAR-FTUs huggingface dataset:
Enhanced antimicrobial properties and bioactivity of 3D-printed titanium scaffolds by multilayer bioceramic coating for large bone defects

The restoration of large bone defects caused by trauma, tumor resection, or infection is a major clinical problem in orthopedics and dentistry because postoperative infections, corrosion, and limited osteointegration of metal implants can lead to loosening of the implant. The aim of this study was to improve the surface properties of a 3D-printed (electron beam melting) Ti6Al4V-based macroporous scaffold by multilayer coating with bioactive silicate glasses (BAGs) and hydroxyapatite doped with a silver (AgHAP) or AgHAP additionally sonochemically modified with ZnO (ZnO-AgHAP). The coated scaffolds AgHAP_BAGs_Ti and ZnO-AgHAP_BAGs_Ti enhanced cytocompatibility in L929 and MRC5 cell lines and expressed bioactivity in simulated body fluid. A lower release of vanadium ions in coated samples compared to bare Ti scaffold indicates decreased dissolution of Ti alloy in coated samples. The coated samples reduced growth of Escherichia coli and Staphylococcus aureus for 4–6 orders of magnitude. Therefore, the 3D-printed Ti-based scaffolds coated with BAGs and (ZnO-)AgHAP have great potential for application as a multifunctional implant with antibacterial properties for the restoration of defects in load-bearing bones.
Effects of Synchronizing Foot Strike and Cardiac Phase on Exercise Hemodynamics in Patients With Cardiac Resynchronization Therapy: A Within-Subjects Pilot Study to Fine-Tune Cardio-Locomotor Coupling for Heart Failure

BACKGROUND: Despite advances in medical and cardiac resynchronization therapy (CRT), individuals with chronic congestive heart failure (CHF) have persistent symptoms, including exercise intolerance. Optimizing cardio-locomotor coupling may increase stroke volume and skeletal muscle perfusion as previously shown in healthy runners. Therefore, we tested the hypothesis that exercise stroke volume and cardiac output would be higher during fixed-paced walking when steps were synchronized with the diastolic compared with systolic portion of the cardiac cycle in patients with CHF and CRT. METHODS: Ten participants (58±17 years of age; 40% female) with CHF and previously implanted CRT pacemakers completed 5-minute bouts of walking on a treadmill (range, 1.5–3 mph). Participants were randomly assigned to first walking to an auditory tone to synchronize their foot strike to either the systolic (0% or 100±15% of the R-R interval) or diastolic phase (45±15% of the R-R interval) of their cardiac cycle and underwent assessments of oxygen uptake (V̇o2; indirect calorimetry) and cardiac output (acetylene rebreathing). Data were compared through paired-samples t tests. RESULTS: V̇o2 was similar between conditions (diastolic 1.02±0.44 versus systolic 1.05±0.42 L/min; P=0.299). Compared with systolic walking, stroke volume (diastolic 80±28 versus systolic 74±26 mL; P=0.003) and cardiac output (8.3±3.5 versus 7.9±3.4 L/min; P=0.004) were higher during diastolic walking; heart rate (paced) was not different between conditions. Mean arterial pressure was significantly lower during diastolic walking (85±12 versus 98±20 mm Hg; P=0.007). CONCLUSIONS: In patients with CHF who have received CRT, diastolic stepping increases stroke volume and oxygen delivery and decreases afterload. We speculate that, if added to pacemakers, this cardio-locomotor coupling technology may maximize CRT efficiency and increase exercise participation and quality of life in patients with CHF.
Cenozoic reactivation of the Great Glen Fault, Scotland: additional evidence and possible causes

The Great Glen Fault trends NNE–SSW across northern Scotland. According to previous studies, the Great Glen Fault developed as a left-lateral strike-slip fault during the Caledonian Orogeny (Ordovician to Early Devonian). However, it then reactivated right-laterally in the Tertiary. We discuss additional evidence for this later phase. At Eathie and Shandwick, minor folds and faults in fossiliferous Jurassic marine strata indicate post-depositional right-lateral slip. In Jurassic shale, we have found bedding-parallel calcite veins (‘beef’ and ‘cone-in-cone’) that may provide evidence for overpressure development and maturation of organic matter at significant depth. Thus, the Jurassic strata at Eathie and Shandwick accumulated deeper offshore in the Moray Firth and were subject to Cenozoic exhumation during right-lateral displacement along the Great Glen Fault, as suggested by previous researchers. Differential sea-floor spreading along the NE Atlantic ridge system generated left-lateral transpressional displacements along the Faroe Fracture Zone from the Early Eocene to the Late Oligocene (c. 47–26 Ma), a period of uplift and exhumation in Scotland. We suggest that such differential spreading was responsible for reactivation of the Great Glen Fault. Indeed, left-lateral slip along the Faroe Fracture Zone is compatible with right-lateral reactivation of the Great Glen Fault.
First record of Seymouria (Vertebrata: Seymouriamorpha) from Early Permian fissure fills at Richards Spur, Oklahoma

Isolated skeletal elements of the amphibian genus Seymouria were recently discovered at the Richards Spur locality near Fort Sill, Oklahoma, a prolific source of Early Permian tetrapod remains. Five of the seven described bones are of juvenile size and include three neural arches, a humerus, and a femur, whereas the other two are partial vertebrae, apparently adult. All seven are morphologically similar to equivalent skeletal elements in Seymouria specimens previously collected in Europe and North America, apart from features reflecting the early developmental stage of the juvenile bones. The femur and humerus are clearly distinct from those of other seymouriamorphs such as Ariekanerpeton and Kotlassia. The rarity of Seymouria at the Richards Spur locality implies that it was not a regular component of the fauna, and it is also associated with the less markedly terrestrial assemblage that consistently occurs at localities in the southwestern United States. However, its skeletal morphology and occurrence a.
The ‘Oldhaven magnetozone’ in East Anglia: a revised interpretation

Abstract A palaeomagnetic study has been carried out on the type Harwich Formation and basal London Clay Formation in the Ispwich area of East Anglia. Both units were deposited during the middle part of geomagnetic Chron C24r. The normal polarity magnetization previously identified in the upper part of the Harwich Formation at Wrabness (Townsend & Hailwood 1985, Journal of the Geological Society, London, 142, 1–27), and called the ‘Oldhaven magnetozone’ by these authors, is now regarded as a recent overprint. The new information is critical in linking the Paleocene-Eocene boundary to NW Europe where the internationally recognized early Eocene Ypresian stage stratotype is defined.
Characterization of the pancreas of common pheasant (Phasianus colchicus): A light and transmission electron microscope study

The present work was carried out to investigate the structure and ultra structure of the pancreas in the common pheasant (Phasianus colchicus). Totally, five healthy adult pheasant were used. The pancreas was assessed using histochemistry and transmission electron microscopy (TEM). The pancreas was composed of four lobes: dorsal, ventral, third, and splenic lobes. These lobes emptied into ascending duodenum through three excretory ducts as: ventral duct, splenic duct, and a common duct for dorsal and third lobes. The exocrine pancreas was constituted of pyramidal‐shaped acinar cells with aggregation of zymogen granules at their apical cytoplasm. The endocrine pancreas was identified as large islet of Langerhans as α islets and small islets as β ones. No mixed islet was observed. At the level of TEM, two types of acinar cells were distinguished: Dark cells with electron dense cytoplasm, and indented nucleus, Light cells with electron lucent cytoplasm, and regular nucleus. The α islets were mainly constituted by A and D cells, whereas the β islets principally contained B cells and a few A cells. No D cells were identified in β islets. B cells were characterized by their polymorphic granules which were surrounded by a narrow halo zone. The granules of D cells were quite different. These cells contained large spherical granules with lower density as compared to the A or B granules surrounded by a limiting membrane. In conclusion, the pancreas of the common pheasant has a species‐specific feature which must be considered in phylogenic studies.
Seasonal, Diurnal and Spatial Variations of Environmental Variables in Australian Livestock Buildings

Abstract To identify the most practical and representative sampling locations for air quality and environmental variables inside intensive piggery buildings, the variation in the spatial, diurnal and seasonal concentration of major airborne pollutants, and related environmental parameters, were analysed over a 2.5-day period at several locations within different piggery buildings. Major airborne pollutants including, ammonia, carbon dioxide, and airborne particles were monitored along with environmental parameters of airspeed, temperature and humidity. To determine the air quality within each building, cyclone attachments were installed to measure particles of less than 5 mm along with a seven hole sampler attachment to measure inhalable airborne particles. An Osiris optical particle counter also monitored the concentrations of airborne particles. Ammonia and carbon dioxide were monitored using a multi-gas monitoring machine and airspeed was measured using a hot-wired anemometer. Interesting patterns in the concentration of carbon dioxide, dust and ammonia were observed over time and space. Carbon dioxide, airspeed and dust concentration demonstrated an obvious circadian pattern. The difference in the concentrations of ammonia and carbon dioxide was not statistically significant at alternative sampling locations inside each building. However, the gravimetric measurements indicated that the concentrations of inhalable particles were not uniform throughout the buildings and proved to be higher above the walkways. Ammonia and respirable particle concentrations were significantly higher in summer when compared to winter conditions. These results combined, identified the most appropriate sampling times and sampling places for reliable evaluation of air quality in intensive livestock buildings.
Thin crust, ultramafic exposures, and rugged faulting patterns at the Mid-Atlantic Ridge (22°–24°N)

Off-axis rock sampling in the lat 22°–24° N region of the Mid-Atlantic Ridge shows that the emplacement of mantle-derived rocks in the sea floor has been a common process there for the past few million years. We find a good correlation between domains of positive residual gravity anomalies (inferred to have a thin crust) and the distribution of ultramafic samples. We also find that thin-crust domains have a rugged topography, thought to reflect strong tectonic disruption. We propose that these thin-crust domains are made of tectonically uplifted ultramafic rocks, with gabbroic intrusions and a thin basaltic cover. We also suggest that strong tectonic disruption may be a direct consequence of the lithological and rheological heterogeneity of these thin-crust domains.
Liver impairment associated with disease progression in COVID‐19 patients

Withdrawal: Benhong Zhou, Liver impairment associated with disease progression in COVID‐19 patients, Accepted Articles, (https://onlinelibrary.wiley.com/doi/abs/10.1111/liv.14481). The above article, published online on 15 April 2020 in Wiley Online Library (wileyonlinelibrary.com) as an Accepted Article, has been withdrawn by agreement between the authors, the journal Editor in Chief, and John Wiley & Sons Ltd. The article has been withdrawn at the authors' request because, on reflection, the authors decided that the opinions expressed in the paper were incomplete and not ready for publication.
The problem of the katabatic winds on the coast of Terre Adélie

The cause of the phenomenally high winds recorded by Sir Douglas Mawson's party at Cape Denison during the Australasian Antarctic Expedition, 1911–14 (Mawson, 1939), and by the French expedition to Port Martin in 1950–51 (Boujon, 1954) has never been satisfactorily explained. As indicated in the Table, the annual mean wind recorded at those stations, 71·1 and 64·6 km per h respectively, is about 70 per cent greater than recorded elsewhere around the coast at stations fully exposed to katabatic flow, notably Mirny and Mawson. Admittedly, the total number of coastal stations is small, considering the length of the Antarctic coastline, and one cannot exclude the possibility that similar very strong winds prevail in other places. Nevertheless, the figures for Cape Denison and Port Martin are notable, if not unique, and the question arises why this should occur on the coast of Terre Adélie.
New insights into magma dynamics during last two eruptions of Mount Etna as inferred by geochemical monitoring from 2002 to 2005

Two distinct eruptive events characterize the volcanic activity at Mount Etna during the 2002 to 2005 period. We identified signals of magma ascent preceding these eruptions by geochemical monitoring of both chemical composition and He‐isotope ratio of gas emissions from five locations in the peripheral area of the volcano. The geochemical signals are interpreted using the models proposed by Caracausi et al. (2003a, 2003b) and allow identification of episodes of magma ascent and estimation of the pressures of degassing magma. As observed for the 2001 eruption (Caracausi et al., 2003b), magma ascent probably triggered the onset of the 2002–2003 eruption, and minor events of magma ascent were observed between May and December 2003. In contrast to the previous two eruptions, the 2004–2005 eruption was not preceded by significant geochemical signals of volcanic unrest, suggesting that this eruption was mainly triggered by the failure of the upper portion of the volcanic edifice under the magmatic hydrostatic pressure in the conduits. High 3He/4He ratio revealed new volatile‐rich magma accumulation. The 2002–2003 eruption was preceded by a much shorter period of new magma accumulation from deep levels of the feeding system. Few minor signals of magma migration were detected at some of the sites during the months preceding the 2004–2005 eruption, suggesting that the degassed 3He‐depleted magma resident in the volcanic conduits was not replaced by new volatile‐rich magma. This is in agreement with the lack of explosive activity during the 2004–2005 eruption and with petrologic observations that the parent magma probably erupted in 2000 and 2001. New geochemical signals of magma ascent from the deep reservoir have been identified since June 2005, indicating that the volcanic activity of Mount Etna is evolving toward new pre‐eruptive conditions.
Gravity Waves in the Thermosphere Simulated by a General Circulation Model

[1] By using a general circulation model that contains the region from the ground surface to the upper thermosphere, characteristics of gravity waves in the mesosphere and thermosphere are examined. At 100 km height, the dominant periods of gravity waves for zonal wave number 20 (zonal wavelength λx ≈ 2000 km), 40(λx ≈ 1000 km) and 80 (λx ≈ 500 km) are 6 h, 3 h and 1.5–2 h, respectively. For the individual zonal wave numbers, the corresponding dominant period becomes shorter at higher altitudes due to dissipation processes in the thermosphere, such as molecular viscosity and ion drag force. This means that gravity waves with larger horizontal phase velocity (larger vertical wavelength) can penetrate into the lower thermosphere. The vertical energy flux due to gravity waves indicates that upward propagation from the lower atmosphere to the thermosphere is dominant. Fluctuations of the horizontal wind associated with gravity waves and its relation to the ionospheric variation are discussed. Short-period gravity waves into the thermosphere induce day-to-day variations of the zonal wind in the upper thermosphere. This result suggests that day-to-day variability of the zonal wind caused by gravity waves is expected to contribute to the ionospheric variability.
Notes on the Birds of Central Oaxaca, Part II: Columbidae to Vireonidae

Notas sobre las aves de Oaxaca central, parte II: Columbidae a VireonidaeSe reportan nuevos datos que amplían y clarifican nuestro conocimiento del estatus y distribución de 70 especies de aves en la región central del Estado de Oaxaca. Las observaciones se realizaron abarcando partes de los distritos de Etla, Ixtlan, Tlacolula, y Zaachila, dentro de un círculo de radio de 35 km alrededor de la Ciudad de Oaxaca. El reporte se basa en observaciones tomadas durante 738 días, comprendidos entre diciembre 1996 y marzo 2002. Los hábitats principalmente visitados fueron pino-encino (incluyendo zonas pequeñas de pino-encino-oyamel y pino-encino mezclado con pastizales), matorral de encino, matorral subtropical, vegetación riparia, y vegetación secundaria, campos agrícolas y otros (incluyendo áreas urbanas, como jardines y parques). Las siguientes especies se reportan por primera vez en la zona: Heliomaster constantii, Tilmatura dupontii, Empidonax flaviventris, Empidonax virescens, Myiarchus crinitus, Myiodynastes luteiventris, Vireo philadelphicus, Vireo olivaceus y Vireo flavoviridis. Además, las siguientes diez especies se han reportado anteriormente una sola vez o solamente en los Conteos Navideños: Caprimulgus ridgwayi (residente),Panyptila sanctihieronymi (residente local), Amazilia cyanocephala (residente local), Amazilia viridifrons, Lamprolaima rhami, Momotus mexicanus (residente en la Sierra Juárez), Sayornis phoebe, Myiozetetes similis (residente), Pachyramphus major (residente) y Vireo griseus. Se reportan datos de la reproducción de 25 especies, 18 de las cuales no se habían registrado como reproduciéndose en la zona antes. De estos, 24 se pueden agrupar como reproduciéndose en los meses de abril a julio, y 17 se reproducen en zonas riparias, seis de ellos casi exclusivamente.
What Are the Net Benefits of Reducing the Ozone Standard to 65 ppb? An Alternative Analysis

In October 2015, the United States Environmental Protection Agency (EPA) lowered the level of the ozone National Ambient Air Quality Standard (NAAQS) from 0.075 ppm to 0.070 ppm (annual 4th highest daily maximum 8-h concentration, averaged over three years). The EPA estimated a 2025 annual national non-California net benefit of $1.5 to $4.5 billion (2011$, 7% discount rate) for a 0.070 ppm standard, and a −$1.0 to $14 billion net benefit for an alternative 0.065 ppm standard. The purpose of this work is to present a combined toxicological and economic assessment of the EPA’s benefit-cost analysis of the 2015 ozone NAAQS. Assessing the quality of the epidemiology studies based on considerations of bias, confounding, chance, integration of evidence, and application of the studies for future population risk estimates, we derived several alternative benefits estimates. We also considered the strengths and weaknesses of the EPA’s cost estimates (e.g., marginal abatement costs), as well as estimates completed by other authors, and provided our own alternative cost estimate. Based on our alternative benefits and cost calculations, we estimated an alternative net benefit of between −$0.3 and $1.8 billion for a 0.070 ppm standard (2011 $, 7% discount rate) and between −$23 and −$17 billion for a 0.065 ppm standard. This work demonstrates that alternative reasonable assumptions can generate very difference cost and benefits estimates that may impact how policy makers view the outcomes of a major rule.
Delivery technique plays an important role in determining vessel wall apposition of the Enterprise self-expanding intracranial stent

Background The Enterprise (EN) vascular reconstruction device is a self-expanding nitinol stent used as adjunctive support in wide-necked aneurysm coiling. We sought to evaluate the effect of deployment technique on how well the EN stent conforms to the vessel wall around a curve. Methods A flow model consisting of a 3.5 mm diameter silicone tube forming a 7 mm radius curve was visualized using high-resolution flat-panel CT (FPCT; DynaCT). EN stents (4.5 mm×22 mm) were deployed using three methods: (1) microcatheter pull-back, (2) delivery microwire push and (3) a combination of both methods so as to keep the microcatheter tip centered within the lumen during deployment. FPCT images were visualized using multiplanar reconstruction for evidence of incomplete stent apposition (ISA). Results FPCT revealed a critical role for deployment method in stent–wall apposition as noted by the development of a crescent-shaped gap between the stent and the wall. Specifically, the manufacturer-recommended microcatheter pull-back unsheathing technique (method 1) resulted in outer curve ISA, while the microwire push technique (method 2) led to inner curve ISA. Using method 3 in a dynamic push–pull manner minimized both inner and outer curve ISA. Conclusion The deployment method used to deliver the EN vascular reconstruction device plays a critical role in determining how well its struts appose the vessel wall in vitro. This characteristic must be taken into account when deploying this flexible low-profile stent to avoid ISA in even mildly tortuous anatomy given the possible link between stent malapposition and thromboembolic complications.
Middle and late Holocene sea-levels along the Israel Mediterranean coast — evidence from ancient water wells

During the course of a study of historical water wells along the Israeli shore, which has been in progress since 1984, an innovative method for investigating sea-level fluctuations was developed. Eighteen ancient water wells were re-dug, 14 by the author, and four by archaeologists. Most of the re-dug wells are found at archaeological sites located a very short distance inland from the present shoreline. Evidence of ancient ground-water levels found in the wells directly reflects on historic eustatic sea-level changes, and the rate at which the end of the post-glacial transgression advanced. A critical question concerns the durability and life span of these wells, as the true age is very important for the accurate reconstruction of a sea-level curve. The Pre-Pottery Neolithic well of Atlit-Yam, which is the oldest known well in the world (ca. 8000 yr old), enabled the most accurate sea-level reconstruction for early Holocene times. Sea-level rise during that period of the Atlit-Yam site was of the order of 20 mm yr−1 at the beginning, slowing to 6–8 mm yr−1 at the abandonment of this site at ca. 7.5 ka BP, when it was flooded by the advancing and rising sea. After reaching its present level, sea-level fluctuations for the past 2.5 millennia were not greater than 1.5 to 2 m. © 1997 John Wiley & Sons, Ltd.