Miracle-dz/UniFAR-FTUs huggingface dataset:
PIM1 inhibitor synergizes the anti-tumor effect of osimertinib via STAT3 dephosphorylation in EGFR-mutant non-small cell lung cancer

Background An increasing amount of evidence has demonstrated that combined or multiple targeted therapies could bring about more durable clinical outcomes, and it is known that epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) resistance is related to bypass activation. This study aims to explore a specific solution for third-generation EGFR-TKI resistance caused by bypass activation, and to examine the antitumor effects of the combination of a novel inhibitor CX-6258 HCl with osimertinib, along with its underlining mechanisms. Methods A bioinformatics analysis was performed to detect the relations between the provirus integration site for Moloney murine leukemia virus 1 (PIM1) expression and prognosis of lung cancer. The EGFR-mutated lung cancer cell lines were treated with the combination of CX-6258 HCl and osimertinib to analyze cell proliferation using the Cell Counting Kit-8, colony formation, and in vivo experiments. Cell migration was analyzed using wound healing and Transwell assays. The apoptosis level was detected using Annexin V–propidium iodide flow cytometry. The expression levels of EGFR and STAT3 were determined using Western blot analysis. Results High expression level of PIM1 was related to the poor prognosis of non-small cell lung cancer (NSCLC). The combined administration of osimertinib and CX-6258 HCl significantly inhibited cell proliferation and migration and effectively induced apoptosis in lung cancer cells. It was more efficient in suppressing EGFR activation and phosphorylation of STAT3 compared with osimertinib treatment alone. Furthermore, it showed a durable efficacy in a xenograft model. Conclusions This study showed that PIM1 is a poor prognostic factor for NSCLC. CX-6258 HCl is a potential molecular inhibitor to sensitize the antitumor effects of osimertinib through the inhibiting of the phosphorylation of STAT3 in NSCLC.
SJIM-V9-N1 MRV.indd

Background: Objectives: To investigate the development of two-cell mouse embryos in vitro at diff erent external environment factors (osmolarity) and demonstrate if the embryo at early stage of development is sensitive to osmotic stress or not. Methods: A total of 173 mouse embryos were collected during the period of January 2018 until July 2018. One NMRI male mouse was caged with the female mice CD1 for natural mating. Th e female mice were fl ushed of the two-cell embryos from the oviduct aft er 24 hours. Th e mating was confi rmed by the presence of a plug in the vagina (whitish gelatine substance in the vagina) next day. Th e osmolarity values were measured by advanced micro-osmometer. One-way ANOVA test was used to compare between diff erent values of osmolarity. Results: Th e fi ndings indicated that the increased osmotic pressure can signifi cantly aff ect the rate of development. Th e developmental rate of two-cell mouse embryos was signifi cantly decreased when cultured in 310 milliosmole and signifi cantly increased in 280 milliosmoles as compared to the 260 milliosmole control group (9.52 ± 16.49, P < 0.001; 83.3 ± 28.7 to 76.29 ± 31.92, P < 0.001). Conclusion: Th e study has concluded that the osmotic pressure can aff ect the rate of development and it depends on the quality of environment. Th e data observed from the mouse embryos might also be helpful in humans and shed light on the eff ect towards human embryos.
Telephone survey of inguinal hernia repair patients older than 5 years for chronic pain

Inguinal hernia is one of the most frequent operations performed in childhood. Frequency of inguinal hernia is 0.8-4.4% in children. Presence of family history increases the frequency to 11.5%. Classical postoperative complications of inguinal hernia in children are spermatic cord/testicle injuries, wound infection, postoperative hematoma, persistent hydrocele and recurrence. There is not much information about postoperative chronic pain and its management.
Business Environment and Dual-Track Private Sector Development: China's Experience in Two Crucial Decades

A void in the literature on the business environment is how it evolves over time. Focusing on China during its crucial two decades of transition (from the early 1990s to the early 2010s), this paper documents how the country's business environment and the characteristics of entrepreneurs evolved, along with the role played by local governments. Relying on multiple comprehensive data sets, the paper shows that many aspects of local business environments improved: infrastructure, development of the court system, and access to external finance. Meanwhile, the share of politically connected private firms remained large, and their advantage in accessing key resources increased. Under this dual-track private sector development, private firms became larger and more innovative and adopted more formal corporate governance mechanisms. Entrepreneurs became much better educated, with more diverse sectoral experience. Market competition increased over time, especially after China's World Trade Organization entry. The paper offers suggestive evidence that this dual track development had negative consequences, such as a lower tendency to innovate by politically connected firms.
Status and trends of dam removal in the United States:

Aging infrastructure coupled with growing interest in river restoration has driven a dramatic increase in the practice of dam removal. With this increase, there has been a proliferation of studies that assess the physical and ecological responses of rivers to these removals. As more dams are considered for removal, scientific information from these dam-removal studies will increasingly be called upon to inform decisions about whether, and how best, to bring down dams. This raises a critical question: what is the current state of dam-removal science in the United States? To explore the status, trends, and characteristics of dam-removal research in the U.S., we searched the scientific literature and extracted basic information from studies on dam removal. Our literature review illustrates that although over 1200 dams have been removed in the U.S., fewer than 10% have been scientifically evaluated, and most of these studies were short in duration (<4 years) and had limited (1–2 years) or no pre-removal monitoring. The majority of studies focused on hydrologic and geomorphic responses to removal rather than biological and water-quality responses, and few studies were published on linkages between physical and ecological components. Our review illustrates the need for long-term, multidisciplinary case studies, with robust study designs, in order to anticipate the effects of dam removal and inform future decision making. Published 2016. This article is a U.S. Government work and is in the public domain in the USA.
Does androgen deprivation therapy impact subjective cognitive function in men with non-metastatic prostate cancer?

Androgen-deprivation therapy is used to treat almost 50% of current prostate cancer patients. Despite slowing disease progression and prolonging survival, androgendeprivation therapy is associated with numerous side effects. However, the impact of androgen-deprivation therapy on subjective cognitive function remains uncertain, as the studies published in this area have assessed objective cognitive function and are limited by small sample sizes and inconsistent findings. The primary objective for this thesis was to determine whether there was a change in subjective cognitive scores over a 12-month period in non-metastatic prostate cancer patients receiving ADT compared to controls. The secondary objectives were to examine the relationship between subjective cognitive function and socio-demographic variables, and change in subjective and objective cognitive function over the 12-month period. Change scores between baseline and 12 months analyzed with adjusted multivariable linear regression models showed no significant change in the prostate cancer patients receiving androgen-deprivation therapy compared to the other control groups.
Study of the Relationship Between Blood Parameters with Skin Mycoses

Corresponding author: Alaa Abdul Hussein Al-Daamy Email: alaa.aldaamy@uokerbala.edu. iq Department of Clinical Laboratories College of Applied Medical Sciences University of Kerbala Kerbala Iraq ABSTRACT Objectives: The aim of the study was to investigate the relationship between some blood parameters and types of infection in patients with skin mycoses. Methods: Blood samples were collected for thirty-seven patients with dermatophytoses and superficial mycoses who visited hospitals and private clinics in the holy cities of Karbala and Babel. Then was done ABO and Rh tests and record all information about them. Results: Thirty-seven patients aged between 8 to 61 years with skin fungi were among them 17 males(46%) and 20 females(54%), there is a significant difference (P<0.05) between males and females and the result indicate to females more likely to these diseases with significant differences. Most patients with mycoses were from the blood group O with 59% , and the patients of Rh + are the most susceptible in mycosis contagion with 95% while the Rh with 5% of patients. It was established that most patients are those who animate in Urban with a percentage 73%. The results showed tinea versicolor is the most clinical manifestation of a patient with 70% of study sample. Patients aged between 17 25 years were the most susceptible to superficial and cutaneous mycosis infections. Conclusion: There is a relationship between factors such as age, sex, blood groups, Rh and housing with skin mycoses.
Comparison of granulated and loose ash in fertilisation of Scots pine on peatland

The effects of wood ash fertilisation on tree nutrition and growth on forested peatlands has been studied using loose ash, but in practice, ash fertilisation is done almost exclusively with granulated ash. In this study, the effects of granulated ash and loose ash (both 5 Mg ha–1) on the growth and nutrition of Scots pine (Pinus sylvestris L.) stands were compared between a nitrogen-poor and a nitrogen-rich site over 15 years. On the nitrogen-rich site, wood ash application was also compared with commercial PK fertilisation. On the nitrogen-rich site, mean stand volume growth increase over unfertilised control treatment during the 15 year study period using granulated ash and commercial PK fertiliser was of the same magnitude (on average, 2.2–2.3 m3 ha–1 a–1). However, when loose ash was used growth increase over control was higher (3.7 m3 ha–1 a–1). On the nitrogenpoor site, the mean growth increase gained by loose or granulated ash (1.4–1.5 m3 ha–1 a–1) over the unfertilised control treatment was not significant. Fertilisation with loose ash or PK increased foliar P, K and B concentrations already in the first or second growing season, following fertilisation on both sites. Granulated ash increased foliar P concentrations on the nitrogen-rich site less than loose ash. After an initial increase, foliar P, K and B concentrations decreased at the end of study period. On the nitrogen-poor site, foliar P concentrations were below the deficiency limit by the end of the study period.
ANALYSIS OF EMPIRICAL LITERATURE OF SAVING DETERMINANTS

This paper deals with the analysis of the empirical literature of the determinants of saving. Capital accumulation in the form of savings is becoming an increasingly significant source of investment financing and economic growth. The review of the empirical literature determines what the statistically significant factors that determine savings are. Empirical works were obtained by proving the direction and strength of the relationship between the observed phenomena, using different methodology, with or without examining the maturity effects of particular saving factors. Statistically significant determinants of savings can be grouped into the following groups: financial determinants (deposit interest rate, financial market development, stock market development), demographic determinants (dependent population rate, life expectancy, urbanization rate), education and employment (education level, form employment), government policy (public revenues and expenditures, public savings / budget deficit, forms of social assistance), income, macroeconomic uncertainty (inflation, CPI changes), external factors (export / import ratio, current account balance, trade balance). The results of this paper provide the basis for building further
The Effectiveness of a 3D-Virtual Reality Learning Environment (3D-VRLE) on the Omani Eighth Grade Students' Achievement and Motivation towards Physics Learning

--This study aimed to examine the effectiveness of a 3D-Virtual Reality Learning Environment the Omani 8th-grade students’ achievement and motivation towards physics learning. To achieve the study objectives, data were collected using two instruments: an achievement test and a motivation questionnaire. The sample consisted of sixty-five female students. They were divided into two groups, (32) students in the experimental group and (33) students in the control group. The findings of this research study indicated a greater improvement in students’ achievement in physics after using the 3D-VRLE compared to their counterparts in the traditional learning environment. Furthermore, the results showed that the 3D-VRLE has a positive effect on students’ motivation towards physics learning. In the light of these findings, the study recommended the importance of using the 3D-VRLE in the Ministry of Education schools. Research areas for future investigation in the field of the 3D-VRLEs were also suggested.
The Impact of Education on Fluid Intelligence

Fluid intelligence, which refers to the ability of a person to solve novel problems independent of previously acquired knowledge, is a highly crucial factor in learning and has a big impact on educational and professional success. However, the impacts of formal education on fluid intelligence has been neglected in the literature. In this paper, we apply an exogenous variation in years of schooling to explore the impacts of education on fluid intelligence. From 1971 to the end of 1973, the global price of crude oil increased over 400%. Such an increase in oil price improved the revenue of the Indonesian government from oil production. Indonesia invested most of the new income on central government’s construction projects famous as “Presidential Instructions” (INPRES), which aimed to improve regional equity in the country. The largest INPRES program, known as Sekolah Dasar INPRES, also remains the largest school construction project in history. The government built over 60 thousand elementary schools all over the country from 1973 to 1978. Duflo (2001) studies the impacts of the program on years of education. We have received INPRES data from Duflo and combined it with the Indonesian Family Life Survey (IFLS), which contains individual cognitive ability tests. This dataset represents 83% of the population of 13 out of 26 Indonesian provinces. The results show positive and statistically significant impacts of years of schooling on the fluid intelligence of both females and males.
Prevalence of Anterior Open bite In Orthodontic patients In Ramadi City

Background: Anterior open bite is vertical dental separation between the upper and lower incisors when the posterior teeth are in full occlusion and lead to malocclusion which effect the esthetic of the patient and need orthodontic treatment. Objectives: To assess the prevalence of anterior open bite in orthodontic patients in Ramadi city and severity of these cases. Patients and Methods: (400) orthodontic patients of ( 15 – 30 ) years old were examined for the presence or absence of anterior open bite then measure the overbite by Results: (16) patients out of the total number have anterior open bite, (6) are males and (10) are females (8) of them are moderate, (5) of them are severe and (3) of them are extreme. Conclusions: We conclude that over all anterior open bite are (4%) of the cases. The patients with anterior open bite are (62.5%) females and (37.5%) males and the females attending orthodontic clinic more than males. Keyword: open bite, orthodontic patient, prevalence, Ramadi city,Iraq.
Toxicological and neurobehavioral effects of chlorpyrifos and deltamethrin insecticides in mice

The aim of the present study was to determine the acute toxicity of chlorpyrifos and deltamethrin in mice separately and to study their toxic and neurobehavioral effects. Median Lethal Doses (LD50) of chlorpyrifos and deltamethrin were determined depending on up and down method. The oral LD50 of chlorpyrifos was 193.05 mg/kg and of deltamethrin was 15.71 mg/kg in mice. The oral administration of chlorpyrifos 155 mg/kg and deltamethrin 12.56 mg/kg represent 80% of LD50 resulted in acute signs of poisoning that manifested by dyspnea, salivation and lacrimation at 100%, piloerection, straub tail, tremors, convulsions and death at 70% for chlorpyrifos and 60% for deltamethrin and writhing reflex at 20% for chlorpyrifos. Oral administration of chlorpyrifos 310 mg/kg and deltamethrin 24 mg/kg increased severity of toxicosis signs as a percentage of piloerection, straub tail, tremors, seizures and death 100%. As well as decrease the onset of tremors, convulsions and death, writhing reflex which appears at 20% for chlorpyrifos and 10% for deltamethrin. After three hours of chlorpyrifos and deltamethrin oral administration at doses represent 20% and 10% of LD50 there are significantly hypoactivation in open-field activity, significantly increased in the duration of negative geotaxis performance, significantly decreased in head pocking and swimming scores compared to control group. In conclusion we found that deltamethrin was more toxic than chlorpyrifos this is based on the LD50 value. However, the signs of toxicosis and neurobehavioral effects produced by both toxicants were not differential and could not be associated with the toxic level.
Isolation and Characterization of Phosphate Solubilizing Bacteria from Phosphate Solid Sludge of the Moroccan Phosphate Mines

The strains isolated from 7 samples of phosphate sludge were tested for their ability to solubilize phosphate in NBRIP medium with Tricalcium Phosphate (TCP) as the sole source of phosphorus, strains with a high solubility index (PSI) were selected. The isolates obtained have been studied for their ability to solubilize TCP quantitatively, and their phosphate solubilizing activity was estimated by the vanadate-molybdate method. The production of Indol-1-Acetic Acid (IAA), Siderophore, and Hydrogen Cyanide (HCN) by the isolates was tested. The best strains have been identified based on 16S rRNA gene sequence comparisons.
The Effect of Corporate Social Responsibility Performance on the Readability of CSR Using Firm Size, Bussiness Complexity, Leverage, Growth, and CEO’S Characteristics as Control Variables

Using a manually collected sample of 49 corporate social responsibility (CSR) reports issued by Indonesian public companies, this study examines the relationship between the CSR performance and the readability of CSR reports. The study adopts the Fog index to measure the readability of CSR reports and standards of GRI to measure CSR performance from economic, environmental and social perspectives. The results show an insignificant relationship between CSR performance and the readability of CSR reports, indicating that companies in Indonesia are less to tend to obfuscate their narrative disclosures which are the main reason for doing the green wash practice. This study helps investors more comprehensively evaluate the CSR information disclosed on CSR reports. Our results also point to the phenomenon that happened in Indonesia that CSR both in quality and quantity improves from time to time.
Seismic force demand on ductile reinforced concrete shear walls subjected to western North American ground motions: Part 1 — parametric study

A parametric study of regular ductile reinforced concrete (RC) cantilever walls designed with the 2010 National building code of Canada and the 2004 Canadian Standards Association (CSA) standard A23.3 for Vancouver is performed to investigate the influence of the following parameters on the higher mode amplification effects, and hence on the seismic force demand: number of storeys, fundamental lateral period (T), site class, wall aspect ratio, wall cross-section, and wall base flexural overstrength (gw). The study is based on inelastic time-history analyses performed with a multilayer beam model and a smeared membrane model accounting for inelastic shear–flexure–axial interaction. The main conclusions are that (i) T and gw are the studied parameters affecting the most dynamic shear amplification and seismic force demand, (ii) the 2004 CSA standard A23.3 capacity design methods are inadequate, and (iii) a single plastic hinge design may be inadequate and unsafe for regular ductile RC walls with gw < 2.0.
From Supply Chain Connectivity (SCC) to Supply Chain agility (SCA), Adaptability and Alignment: Mediating Role of Big Data Analytics Capability

The main aim of the current study is to analyze the effect of SCC on the large information analysis capability and to analyze the impact of this big data analytics capability on the agility, adaptability and alignment of the supply chain. For this purpose, the current study used RBV as supporting the idea because the idea of RBV suggests that a firm can build its capabilities based on its resources. The data for the current study was collected from 300 employees of manufacturing firms of Thailand through questionnaires and the sample was selected through purposive sampling technique. The analysis and results revealed that SCC has a significant positive role in building big data analytics capability of the firm. Furthermore, it has been found that big data analytics capability enhances the SC qualities to cope with external environment and fluctuations because it significantly positively influences the SCA, adaptability and alignment. The current study and its findings have implications in practice as well as theory because they are expected to make value contributions in both fields.