Miracle-dz/UniFAR-FTUs huggingface dataset:
Medical and psychological aspects of safety and adaptation of military personnel to extreme conditions.

OBJECTIVE The aim: To determine the dynamics of adaptation resources and the level of psychological safety of the personality in service members of the National Guard of Ukraine who participated in combat operations in the East of Ukraine. PATIENTS AND METHODS Materials and methods: To determine the peculiarities of military personnel adaptation to the combat activity, the "Adaptability-200" and "Disdaptability-45" methodologies were used. To determine the level of psychological safety of combatants we used "Diagnosis of psychological safety personality" and "Express diagnosis of psychological safety personality" Methodologies. The study was carried out during 2017, with 163 military participating. RESULTS Results: Being 2-3 weeks in combat conditions, 54% service members revealed high, 32% - average level of adaptability, and in 14% of them signs of non-adaptability were detected. The data of adaptation resources of combatants correlates with the results of diagnostics of psychological safety of personality: in 43% of them high level, 42% - average and 15% - low level of psychological safety were revealed. CONCLUSION Conclusions: The data obtained in the absolute majority of service members (86%) shows a good adaptability to combat conditions, and allows predicting adequate response to extreme conditions, high probability of preserving of the mental health and disability after the influence of vital factors.
Chemical composition and nutritional characteristics of several cereal grain

An analysis chemical composition of 33 samples of five cereal grains harvested in one- year led to a conclusion that the greatest variations and statistically significant differences (P≤0.01) among cereals existed in their content of crude protein, crude fibre and the following fractions of dietary fibre: NDF, ADF, TDF, IDF and SDF. Analyzed winter wheat and winter rye varieties differ significantly (P≤ 0.01) from other cereal grains in their content of magnesium, potassium, sodium, phosphorus, manganese, zinc and show a statistically significant difference (P≤0.05) in the content of calcium and copper. The average total content of amino acids was highest in wheat and lowest in winter barley. Lysine was found to be the first amino acid limiting (CS) the qual - ity of protein in all analyzed varieties of cereal grains, with the exception of rye, while trypto - phan was found to be such an amino acid for animals (WE). The high content of essential amino acids (EAA) was reflected in EAAI, which for WH ranged from 71% (spring barley) to 84% (winter triticale), and for WE from 51% (winter barley) to 60% (winter triticale).
Linking Risk Perception to Breast Cancer Examination Intention in China: Examining an Adapted Cognitive Mediation Model

ABSTRACT Drawn upon the cognitive mediation model, this study proposes an adapted model and examines the mechanisms by which Chinese women’s risk perception of breast cancer becomes associated with their breast cancer examination intention. Our hypothesized model was largely supported by an online survey with a nationwide sample of 458 Chinese women. The results indicated that a person’s perceived risk for breast cancer motivated information seeking and scanning using various mass media and online channels, which then positively predicted the person’s quest for greater elaboration and more interpersonal discussion. In addition, elaboration was positively associated with breast cancer-related factual knowledge and subjective norms, whereas interpersonal discussion only exerted a positive relationship with subjective norms but not factual knowledge. As predicted, knowledge and subjective norms were positively associated with people’s intentions to pursue breast cancer examination. Future research should consider both information seeking and scanning in the process of media learning and reflection. In addition to intrapersonal factors like knowledge, the interpersonal reasoning process that cultivates a favorable social influence is pivotal in promoting breast cancer examination in China.
Characteristics and outcomes of paediatric patients admitted to a Danish level-1 trauma centre.

INTRODUCTION This study sought to expand the very limited data on Scandinavian paediatric poly-trauma patients by charactering patients from this population admitted to a Danish level-1 trauma centre. METHODS This retrospective cohort study included all patients 15 years or younger who were admitted to the trauma centre at Aarhus University Hospital, Denmark from January 2000 to May 2014. Injury severity was calculated using the Injury Severity Score (ISS). The Wilcoxon rank-sum test was used to determine significant differences between sexes. RESULTS A total of 880 children (499 boys and 391 girls) were included. No significant sex-related differences were observed in the numbers admitted during the study period, age at admission or severity of injuries. Overall, 30% of the paediatric patients were admitted in the afternoon (3-6 p.m.). The crude death rate was 2.7% of all admissions. Traffic accidents accounted for 48% of all admissions and two-thirds of all deaths. All non-survivors received ISSs of 16 or higher, and 20% of deaths in this group and 42% of overall deaths occurred within the first 24 hours. CONCLUSIONS Our study suggests that in Denmark, children admitted to a trauma centre are most likely to have been injured in traffic accidents and/or in the afternoon. Deaths were few and limited to the severely injured children; many survived despite severe injuries. FUNDING none. TRIAL REGISTRATION not relevant.
Anterograde trafficking of ciliary MAP kinase–like ICK/CILK1 by the intraflagellar transport machinery is required for intraciliary retrograde protein trafficking

ICK (also known as CILK1) is a mitogen-activated protein kinase–like kinase localized at the ciliary tip. Its deficiency is known to result in the elongation of cilia and causes ciliopathies in humans. However, little is known about how ICK is transported to the ciliary tip. We here show that the C-terminal noncatalytic region of ICK interacts with the intraflagellar transport (IFT)–B complex of the IFT machinery and participates in its transport to the ciliary tip. Furthermore, total internal reflection fluorescence microscopy demonstrated that ICK undergoes bidirectional movement within cilia, similarly to IFT particles. Analysis of ICK knockout cells demonstrated that ICK deficiency severely impairs the retrograde trafficking of IFT particles and ciliary G protein–coupled receptors. In addition, we found that in ICK knockout cells, ciliary proteins are accumulated at the bulged ciliary tip, which appeared to be torn off and released into the environment as an extracellular vesicle. The exogenous expression of various ICK constructs in ICK knockout cells indicated that the IFT-dependent transport of ICK, as well as its kinase activity and phosphorylation at the canonical TDY motif, is essential for ICK function. Thus, we unequivocally show that ICK transported to the ciliary tip is required for retrograde ciliary protein trafficking and consequently for normal ciliary function.
Mouse Sertoli cells isolation by lineage tracing and sorting

Sertoli cells play a key role in spermatogenesis by supporting the germ cells throughout differentiation. The isolation of Sertoli cells is essential to study their functions. However, the close contact of Sertoli cells with other testicular cell types and the high proliferation of contaminating cells are obstacles to obtain pure primary cultures. Current rodent Sertoli cell isolation protocols result in enriched, rather than pure Sertoli cells. Therefore, novel approaches are necessary to improve the purity of Sertoli cell primary cultures. The goal of this study is to obtain pure mouse Sertoli cells using lineage tracing and fluorescence‐activated cell sorting (FACS). We bred the Amh‐Cre mouse line with tdTomato line to generate mice constitutively expressing red fluorescence specifically in Sertoli cells. Primary cultures of Sertoli cells isolated from prepubertal mice showed that 79% of cells expressed tdTomato, as evaluated by fluorescence microscopy and flow cytometry; however, nearly all adherent cells were positive for vimentin. Most of the tomato‐negative cells expressed α‐smooth muscle actin (α‐SMA), a peritubular myoid cell marker, but double‐negative populations were also present. These findings suggest that vimentin lacks Sertoli cell‐specificity and that α‐SMA is not adequate to identify all of the contaminating cells. Upon FACS sorting; however, virtually 100% of the cells were tdTomato positive, expressed vimentin, but not α‐SMA. Prepubertal mice yielded a higher number of Sertoli cells compared to adults, but both could be adequately sorted. In conclusion, our study shows that lineage tracing and sorting is an efficient strategy for acquiring pure populations of murine Sertoli cells.
POTENTIAL OF FOUR SPECIES OF PREDATORY MITES AS BIOLOGICALCONTROL AGENTS OF THE TOMATO RUSSET MITE, ACULOPS LYCOPERSICI (MASSEE) (ERIOPHYIDAE)

Abstract Predation experiments were conducted to identify a predator with the capacity to control the tomato russet mite, Aculops lycopersici (Massee) (Eriophyidae), in greenhouse tomato crops. The efficiency of four predatory mites species was evaluated at the individual level in the laboratory: the tydeid Homeopronematus anconai (Baker) and the phytoseiids Phytoseiulus persimilis Athias-Henriot, Amblyseius cucumeris Oudemans, and A. fallacis Garman. The first three species had already been suggested as potential control agents. Predation by P. persimilis was essentially zero on tomato russet mite, whereas H. homeopronematus failed to develop to the adult stage when fed solely with this prey. Amblyseius cucumeris developed successfully on tomato russet mite but failed to reproduce. Only A. fallacis appears to possess several of the biological attributes required to control the tomato russet mite. This species attacks all stages of the pest and displays excellent survival (.92%), adequate rate of development (6.3 days at 22 °C), and good reproductive capacity in the presence of A. lycopersici. Résumé Des expériences sur la prédation ont permis d’identifier un prédateur efficace de l’ériophyide de la tomate, Aculops lycopersici (Massee) (Eriophyidae), dans les cultures de tomates en serre. L’efficacité de quatre espèces prédatrices d’acariens a été évaluée en laboratoire sur une base individuelle : le tydéide Homeopronematus anconai (Baker) et les phytoséiides Phytoseiulus persimilis Athias-Henriot, Amblyseius cucumeris Oudemans, et A. fallacis Garman. Les trois premières espèces ont déjà été suggérées comme agents possibles de lutte. La prédation exercée par P. persimilis sur A. lycopersici s’est avérée à peu près nulle, et H. homeopronematus ne réussissait pas à atteindre le stade adulte en se nourrissant exclusivement de cette proie. Amblyseius cucumeris se développait normalement en consommant l’ériophyide, mais ne parvenait pas à se reproduire. Seulement A. fallacis semble posséder toutes les propriétés nécessaires à la lutte contre l’ériophyide de la tomate : cette espèce s’attaque à tous les stades de l’espèce cible, a un excellent taux de survie (.92%), un taux convenable de développement (6,3 jours à 22 °C) et une capacité de reproduction adéquate en présence d’A. lycopersici. [Traduit par la Rédaction]
COVID-19: a wreak havoc across the globe

Abstract Coronavirus disease (COVID-19) is an infectious airborne viral pneumonia caused by a novel virus belonging to the family coronaviridae. On February 11, 2019, the Internal Committee on Taxonomy of Virus (ICTV) announced the name of the novel virus as “severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). One of the proteins present on its membrane i.e. the Spike protein is responsible for the attachment of the virus to the host. It spreads through the salivary droplets released when an infected person sneezes or coughs. The best way to slow down the disease is by protecting self by washing hands and using the disinfectant. Most of the infected people experience mild to moderate breathing issues. Serious illness might develop in people with underlying cardiovascular problems, diabetes and other immuno-compromised diseases. To date, there is no effective medicine available in the market which is effective in COVID-19. However, healthcare professionals are using ritonavir, flavipiravir, lopinavir, hydroxychloroquine and remdesivir. Along with the medicines, some countries are using convalescent plasma and mesenchymal stem cells for treatment. Till date, it has claimed millions of death worldwide. In this detailed review, we have discussed the structure of SARS-CoV-2, essential proteins, its lifecycle, transmission, symptoms, pathology, clinical features, diagnosis, prevention, treatment and epidemiology of the disease.
The Changing Paradigm for the Treatment of HER2-Positive Breast Cancer

For decades, HER2-positive breast cancer was associated with poor outcomes and higher mortality rates than other breast cancer subtypes. However, the advent of Trastuzumab (Herceptin) has significantly changed the treatment paradigm of patients afflicted with HER2-positive breast cancer. The discovery of newer HER2-targeted therapies, such as Pertuzumab (Perjeta), has further added to the armamentarium of treating HER2-positive breast cancers. This review highlights recent advancements in the treatment of HER2-positive diseases, including the newer HER2-targeted therapies and immunotherapies in clinical trials, which have paved (and will further update) the way for clinical practice, and become part of the standard of care in the neoadjuvant, adjuvant or metastatic setting.
Some Behaviour Traits Observed on The Kıvırcık and Crossbred Lambs Raised in Intensive Conditions

In this study, the behaviour responses of the crossbred lambs (F2 (German Black-Headed Mutton x Merino) x F1 (Chios x K›v›rc›k)) were compared with the K›v›rc›k lambs in intensive conditions and the effects of genotype, sex and observation period on the behaviours displayed were investigated. The data were collected from 10 (5 male + 5 female) K›v›rc›k and 10 (5 male + 5 female) crossbred lambs, which were weaned at the age of 2-2.5 months. The effect of genotype was found significant on the behaviours of feed consumption (P < 0.01), activities towards the bedding material (P < 0.05), rumination (P < 0.01), lying (P < 0.01), oral stereotypic behaviours (OSB) (P < 0.01) and behaviours towards animal (BTA) (P < 0.01). Behaviours towards other animals and oral stereotypic behaviours in the crossbred lambs were 50% and 27% more than the K›v›rc›k lambs, respectively. Significant differences in terms of the activities towards the bedding material (P < 0.05), rumination (P < 0.01) and lying (P < 0.01) behaviours were determined between the male and female lambs. It was seen that the male lambs were more active in the breeding area. The effects of observation period were found significant on feeding (P < 0.01), drinking (P < 0.01), rumination (P < 0.01), lying (P < 0.01), standing (P < 0.01), oral stereotypic behaviours (P < 0.01) and behaviours towards animals (P < 0.05). Although the crossbred lambs were more superior for fattening program in terms of live weight gains, they showed more abnormal behaviours (OSB and BTA), which are the signs of stress, in the limited breeding area, depend on the lessening of the area by the rise in their live weights. Genotipin yem tuketme (P < 0,01), altl›¤a yonelim (P < 0,05), ruminasyon (P < 0,01), yatma (P < 0,01), oral sterotipik davran›fllar (OSD) (P < 0,01) ve hayvana yonelik davran›fllar (HYD) (P < 0,01) uzerine etkisi onemli bulunmufltur. Melez kesim kuzular›nda hayvana yonelik ve oral sterotipik davran›fllar K›v›rc›k kuzulara gore s›ras›yla % 50 ve % 27 oran›nda daha fazla gercekleflmifltir. Erkek kuzularla difli kuzular aras›nda altl›¤a yonelim (P < 0,05), ruminasyon (P < 0,01) ve yatma (P < 0,01) davran›fllar› bak›m›ndan istatistiksel olarak onemli farkl›l›klar belirlenmifltir. Erkek kuzular›n yetifltirme ortam›nda daha aktif olduklar› saptanm›flt›r. Gozlem periyodunun, yem tuketme (P < 0,01), su icme (P < 0,01), ruminasyon (P < 0,01), yatma (P < 0,01), dikilme (P < 0,01), oral sterotipik davran›fllar (P < 0,01) ve hayvana yonelik davran›fllar (P < 0,05) uzerine etkisi onemli bulunmufltur. Bu cal›flma, melez kesim kuzular›n›n, beside canl› a¤›rl›k art›fl› bak›m›ndan daha ustun olmalar›na ramen, canl› a¤›rl›klar›n›n artmas› ve buna bal› olarak yaflama alanlar›n›n azalmas› sonucu, stres belirtisi olan anormal davran›flsal tepkileri (OSD ve HYD) daha youn olarak ortaya koyduklar›n› gostermektedir.
Lateral oblique approach for internal jugular vein catheterization: Randomized comparison of oblique and short-axis view of ultrasound-guided technique

OBJECTIVE: The lateral oblique approach is a novel needle-in-plane technique for ultrasound-guided catheterization of the internal jugular vein. In this study, we aimed to compare the oblique approach with the classical short-axis technique for facilitating the procedure and reduction of mechanical complications. METHODS: This research was planned as a prospective study. Eighty-four open-heart surgery patients requiring a central venous catheter were randomly allocated into two groups: Oblique approach group (n=42) and short-axis group (n=42). Time to cannulate, the number of necessary puncture attempts, and frequency of carotid artery puncture, hematoma, puncture site bleeding, pneumothorax, and hemothorax in each group were recorded. Visualization of the vein and the needle using ultrasound were also evaluated by a subjective scale. RESULTS: The patient’s characteristics were comparable between the two groups. The mean time of catheterization was 52.00±70.18 seconds in the oblique approach group and 40.76±49.30 seconds in short-axis group. The mean number of needle puncture attempts was 1.21±0.61 in oblique approach and 1.12±0.50 in short-axis group. The results did not differ significantly. There was an improved visualization of the needle in the oblique approach group, but this was not proved as statistically significant. CONCLUSION: The results of our study suggest that the lateral oblique approach is a safe and effective technique, which can be a strong alternative to the classical short-axis technique for ultrasound-guided catheterization of the internal jugular vein.
Effect of unplanned excision of soft tissue sarcomas on skin defects and reconstructive procedures

Abstract Unplanned excision (UE) is defined as a procedure wherein a surgeon operates a tumor resection without appropriate preoperative diagnostic modalities and without the intent to achieve tumor-free margins. Generally, the reconstruction rate after UE is higher than that after planned excision (PE). The present study aimed to investigate how the reconstructive procedure and size of skin defect could be influenced. We reviewed the cases of 442 patients who underwent the resection of soft tissue sarcoma. Patients were stratified into two groups (UE vs. PE). We compared the histologic grade, skin defect, reconstructive procedures, depth of the reconstruction layer. For superficial reconstructions, we also compared procedures involving skin graft-only or flap. 105 cases (23.8%) were UE. Histologic grade in PE was significantly higher (p = .024). The reconstruction rate and size of skin defect in UE was significantly higher (76.2% vs. 27.3%, p < .001) and larger (124.5 cm2 vs. 65.7 cm2, p < .001). The rate of deep layer reconstruction was significantly higher in PE (7.5% vs. 26.1%, p = .001). In superficial reconstructions, 18 (24.3%) skin graft-only procedures were performed in UE and 15 (22.1%) in PE, all other superficial reconstructive procedures involved flap, and there was no significant difference (p = .45). Skin defects were 1.9 times larger after UE than PE. UE did not affect the superficial reconstructive procedure.
ScalpEye: A Deep Learning-Based Scalp Hair Inspection and Diagnosis System for Scalp Health

Many people suffer from scalp hair problems such as dandruff, folliculitis, hair loss, and oily hair due to poor daily habits, imbalanced nutritional intake, high stress, and toxic substances in their environment. To treat these scalp problems, dedicated services such as scalp hair physiotherapy have emerged in recent years. This article proposes a deep learning-based intelligent scalp inspection and diagnosis system, named ScalpEye, as an efficient inspection and diagnosis system for scalp hair physiotherapy as part of scalp healthcare. The proposed ScalpEye system consists of a portable scalp hair imaging microscope, a mobile device app, a cloud-based artificial intelligence (AI) training server, and a cloud-based management platform. The ScalpEye system can detect and diagnose four common scalp hair symptoms (dandruff, folliculitis, hair loss, and oily hair). In this study, we tested several popular object detection models and adopted a Faster R-CNN with the Inception ResNet_v2_Atrous model in the ScalpEye system for image recognition when inspecting and diagnosing scalp hair symptoms. The experimental results show that the ScalpEye system can diagnose four common scalp hair symptoms with an average precision (AP) ranging from 97.41% to 99.09%.
Correlation-Aware Ordered Transmissions Scheme for Energy-Efficient Detection

Ordered transmissions is an energy-efficient scheme that improves the lifetime of a wireless sensor network (WSN) and yet achieves the same performance as the conventional unordered transmissions scheme (UTS) in which all nodes transmit. We present a novel scheme for the binary hypothesis testing problem that exploits ordered transmissions to reduce the number of transmissions for the general and practically important scenario in which the measurements of the sensor nodes are correlated. It differs from the literature that assumes that, conditioned on the hypotheses, the measurements of different nodes are statistically independent or that the covariance matrix has a special structure. In our scheme, the nodes transmit their measurements in the decreasing order of the magnitudes of the measurements. We present two novel approaches to design the decision rules. These address the presence of crossterms between the measurements of different nodes that now arise in the decision statistic due to correlation and make a distributed implementation challenging. Both our approaches markedly reduce the average number of transmissions compared to UTS and ensure that the error probability remains the same.