Miracle-dz/UniFAR-FTUs huggingface dataset:
Functionality of retinal vessels in central serous retinopathy: A comparison between eplerenone and photodynamic therapy

Purpose To investigate retinal vessels functionality in patients with acute central serous chorioretinopathy (CSC) undergoing oral eplerenone or photodynamic therapy (PDT) using Retinal Vessel Analyzer (RVA) and Dynamic Vessel Analyzer (DVA), respectively. Methods Treatment naïve acute CSC patients presenting between May 2017 and June 2017 were recruited. A complete ophthalmological examination was performed in all participants before and after oral eplerenone (eplerenone group) or half-dose PDT (PDT group). Results Eighteen eyes of 18 patients affected by acute CSC underwent either oral eplerenone (10 eyes of 10 patients, 47.6 ± 8.9 years old) or half-dose PDT (8 eyes of 8 patients, 57.4 ± 6.2 years old), respectively. After 2 months of treatment, non-significant variations of static retinal vessels analysis, dynamic arterial and venous dilatation were reported in eplerenone group. Similarly, in PDT group non-significant variations of static retinal vessels analysis, dynamic arterial and venous dilatation were found after 2 months of treatment. Conclusions Static and dynamic retinal functionalities in acute CSC may not be significantly improved by oral eplerenone and half-dose PDT. Although their choroidal effects, these treatments could not exert a significant effect on retinal vessels motility. Thus, both local and systemic therapies might not help avoiding the onset of vascular and other retinal known alterations of CSC.
Hyperbolic Metamaterial-Based Optical Biosensor for Detecting Cancer Cells

Study was made of a hyperbolic metamaterial (HMM)-based optical biosensor in view of possible usage to detect early-stage cancerous cells. The effective medium theory was used to determine the constitutive properties of the metasurface. The reflectance was obtained under different conditions to observe shifts in spectral minima, thereby determining the status of the measurand. The sensitivity and figure-of-merit (FoM) of the structure were evaluated. Observations revealed the device showing relatively high FoM, which depends on the thickness of the HMM and sensing medium, and also, the radius of nanoholes (in HMM) and the angle of incidence of light waves.
Unified Lightweight Authenticated Encryption for Resource-Constrained Electronic Control Unit

Electronic control units (ECU) have been widely used in modern resource-constrained automotive systems, com-municating through the controller area network (CAN) bus. However, they are still facing man-in-the-middle attacks in CAN bus due to the absence of a more effective authenti-cation/encryption mechanism. In this paper, to defend against the attacks more effectively, we propose a unified lightweight authenticated encryption that integrates recent prevalent cryp-tography standardization Isap and Ascon.First, we reuse the common permutation block of ISAP and Asconto support authenticated encryption and encryption/decryption. Second, we provide a flexible and independent switch between authenticated encryption and encryption/decryption to support specific application requirements. Third, we adopt standard CAESAR hardware API as the interface standard to support compatibility between different interfaces or platforms. Experimental results show that our proposed unified lightweight authenticated encryption can reduce 26.09% area consumption on Xilinx Artix-7 FPGA board compared with the state-of-the-arts. In addition, the encryption overhead of the proposed design for transferring one CAN data frame is $\mathbf{10.75} \mu s$ using Asconand $\mathbf{72.25} \mu s$ using ISAP at the frequency of 4 MHz on embedded devices.
Physics of climate

Physics of Climate is a suitable text for at least part of a general circulation course. The quantity and quality of information in this book are such that anyone involved in the study of the atmosphere or climate will wish to have it handy. In particular, anyone working with a general circulation model will want to see how his model compares with the observed world. Eight chapters are the core of the text. They cover: data description; observed states of the atmosphere, ocean, and cryosphere; exchanges between the atmosphere and the surface; and the budgets of water, angular momentum, and energy.
An Early Enriched Experience Drives an Activated Microglial Profile at Site of Corrective Neuroplasticity in Ten-m3 Knock-Out Mice

Abstract Environmental enrichment (EE) is beneficial for brain development and function, but our understanding of its capacity to drive circuit repair, the underlying mechanisms, and how this might vary with age remains limited. Ten-m3 knock-out (KO) mice exhibit a dramatic and stereotyped mistargeting of ipsilateral retinal inputs to the thalamus, resulting in visual deficits. We have recently shown a previously unexpected capacity for EE during early postnatal life (from birth for six weeks) to drive the partial elimination of miswired axonal projections, along with a recovery of visually mediated behavior, but the timeline of this repair was unclear. Here, we reveal that with just 3.5 weeks of EE from birth, Ten-m3 KOs exhibit a partial behavioral rescue, accompanied by pruning of the most profoundly miswired retinogeniculate terminals. Analysis suggests that the pruning is underway at this time point, providing an ideal opportunity to probe potential mechanisms. With the shorter EE-period, we found a localized increase in microglial density and activation profile within the identified geniculate region where corrective pruning was observed. No comparable response to EE was found in age-matched wild-type (WT) mice. These findings identify microglia as a potential mechanistic link through which EE drives the elimination of miswired neural circuits during early postnatal development. Activity driven, atypical recruitment of microglia to prune aberrant connectivity and restore function may have important therapeutic implications for neurodevelopmental disorders such as autistic spectrum disorder.
Genetics and epigenetics of CLL

Abstract Chronic lymphocytic leukemia (CLL) has a heterogeneous biological behavior, which is highly influenced by its immunogenetic, epigenetic, and genomic properties. The remarkably variable clinical course of the disease has been associated with genetic features such as chromosomal abnormalities, the presence of either high or low numbers of somatic hypermutations (SHM) in the variable region of the immunoglobulin heavy chain locus (IGHV), and somatic mutations of several specific driver genes. Next-generation sequencing (NGS) technologies have provided a comprehensive characterization of the genomic and epigenomic landscape in CLL, elucidating important underlying mechanisms of the disease’s biology. The scope of this review is to summarize the most recent discoveries about novel genetic and epigenetic alterations, discussing their impact on clinical outcomes and response to currently available therapy.
The Quest for Competitive Advantage: The Role of Technology Depth and Breadth at the Customer Interface

Technology is becoming pivotal for firms while interacting with customers. While extensive research exists on how deployment of firm resources, such as technology, leads to competitive advantage (CA), research on the interaction between technology-led firm capabilities deployed at firm customer interaction and CA is limited. We theorize regarding a more effective approach to manage technology by looking at the effects of firm technology resource and capability deployment by a firm in the context of managing different dimensions of TRU at the firm–customer interface. We do so by considering two firm capabilities, namely, technology resource breadth utilization (TRBU) and technology resource depth utilization (TRDU). We use low involvement purchase (LIP) customer purchase context during three customer purchase stages, namely, pre-purchase, purchase and post-purchase to provide structure to the logic. We then build arguments on the relationship between the level of deployment of TRDU and TRBU and attainment of CA under different conditions. We propose testable propositions between TRBU and TRDU levels with CA attained and posit different kinds of relationship like positive, negative and inverted U-shaped relationships having inflexion points to contribute to the theorization in this area.
Cardiovascular risk factors among patients with acute unilateral inner ear hypofunction: A case–control study

To assess the prevalence of cardiovascular risk factors (CVRFs) and their impact on acute unilateral inner ear hypofunction (AUIEH), including acute unilateral peripheral vestibulopathy (AUPVP), sudden sensorineural hearing loss (SSNHL) and acute unilateral audiovestibular hypofunction (AUAVH).
Preliminary experience of cardiac proton spectroscopy at 0.75 T

Recent work on high‐performance lower‐field MR systems has renewed the interest in assessing relative advantages and disadvantages of magnetic fields less than 1 T. The objective of the present work was to investigate signal‐to‐noise ratio (SNR) scaling of point‐resolved spectroscopy as a function of field strength and to test the feasibility of proton MRS of triglycerides (TGs) in human in vivo myocardium at 0.75 T relative to 1.5 T and 3 T. Measurements at 0.75 T were obtained by temporarily ramping down a clinical 3 T MR scanner. System configurations at 0.75, 1.5 and 3 T featured identical hard‐ and software, except for differences in transmit/receive coil geometries and receive channel count, which were accounted for in SNR comparisons. Proton MRS was performed at 0.75 T, 1.5 T and 3 T in ex vivo tissue and in vivo calf muscle to measure T1 and T2 values as a function of field strength, which in turn served as input to simulations of SNR scaling and field‐dependent TG fit errors. Preliminary in vivo spectra of myocardium were acquired at 0.75 T, 1.5 T and 3 T in healthy subjects. Measurements of both ex vivo tissue and in vivo muscle tissue at 0.75 T versus 1.5 T and 3 T confirmed decreasing T1 and increasing T2* for decreasing field strengths. Using measured T1, T2 and T2* as input and using field‐dependent echo time and bandwidth scaling, simulated Cramér‐Rao lower bounds of TG amplitudes at 0.75 T were 2.3 and 4.5 times larger with respect to 1.5 T and 3 T, respectively. In vivo measurements demonstrate that human proton spectroscopy of TGs in cardiac muscle is feasible at 0.75 T, supporting the potential practical value of lower‐field high‐performance MR systems.
How Characters Are Learned Leaves Its Mark on the Neural Substrates of Chinese Reading

Abstract Understanding how the brain functions differently as one learns to read may shed light on the controversial nature of the reading ability of human being. Logographic writing system such as Chinese has been found to rely on specialized neural substrates beyond the reading network of alphabetic languages. The ability to read in Chinese has also been proposed to rely on writing skills. However, it was unclear whether the learning-related alteration of neural responses was language specific or resulted from the more reliance on writing practice during acquisition. This study investigated whether the emergence of typical logographic-specific regions relied on learning by writing. We taught proficient alphabetic language readers Chinese characters and used pre-test and post-test to identify changes in two critical stages of reading, namely, orthographic processing and orthographic-to-phonological mapping. Two typical left hemispheric areas for logographic reading showed increased responses to characters in the brains of proficient alphabetic readers after learning, regardless of whether the learning strategy involved writing practice. Moreover, learning strategy modulated the response magnitude or multivoxel patterns in the left superior parietal lobule, left middle frontal gyrus, and right fusiform gyrus, some of which were task dependent. The findings corroborated a limited role of writing in the emergence of logographic-specific reading network and suggested the heterogeneous nature of different brain regions in this network.
The Relationship between Perceived Social Support and Life Satisfaction: The Chain Mediating Effect of Resilience and Depression among Chinese Medical Staff

Medical staff are direct providers of medical services and a key element in the development of health services, and their life satisfaction is important to both their work satisfaction and their patients’ satisfaction, subsequently influencing the quality of medical care in general. This cross-sectional study aimed to explore the mechanisms underlying the influence of perceived social support on medical staff’s life satisfaction. Convenience sampling was used to recruit participants from two non-tertiary hospitals in Shaoguan City, Guandong Province, China. A total of 533 medical staff completed the Multidimensional Scale of Perceived Social Support, the Satisfaction with Life Scale, the Connor and Davidson Resilience Scale, and the depression subscale of the Depression, Anxiety, and Stress Scales (DASS-21). The results showed that perceived social support could influence medical staff’s life satisfaction not only through the separate effects of resilience and depression, but also through the chain mediation effect of resilience and depression. This study suggests that reducing the depressive symptoms of medical staff and improving their perceived social support as well as resilience could help to enhance their life satisfaction.
Antioxidant Intervention to Improve Cognition in the Aging Brain: The Example of Hydroxytyrosol and Resveratrol

Both physiological and pathological aging processes induce brain alterations especially affecting the speed of processing, working memory, conceptual reasoning and executive functions. Many therapeutic approaches to reduce the impact of brain aging on cognitive functioning have been tested; unfortunately, there are no satisfactory results as a single therapy. As aging is partly contributed by free radical reactions, it has been proposed that exogenous antioxidants could have a positive impact on both aging and its associated manifestations. The aim of this report is to provide a summary and a subsequent review of the literature evidence on the role of antioxidants in preventing and improving cognition in the aging brain. Manipulation of endogenous cellular defense mechanisms through nutritional antioxidants or pharmacological compounds represents an innovative approach to therapeutic intervention in diseases causing brain tissue damage, such as neurodegeneration. Coherently with this notion, antioxidants, especially those derived from the Mediterranean diet such as hydroxytyrosol and resveratrol, seem to be able to delay and modulate the cognitive brain aging processes and decrease the occurrence of its effects on the brain. The potential preventive activity of antioxidants should be evaluated in long-term exposure clinical trials, using preparations with high bioavailability, able to bypass the blood-brain barrier limitation, and that are well standardized.
Multi-tissue RNA-Seq Analysis and Long-read-based Genome Assembly Reveal Complex Sex-specific Gene Regulation and Molecular Evolution in the Manila Clam

Abstract The molecular factors and gene regulation involved in sex determination and gonad differentiation in bivalve molluscs are unknown. It has been suggested that doubly uniparental inheritance (DUI) of mitochondria may be involved in these processes in species such as the ubiquitous and commercially relevant Manila clam, Ruditapes philippinarum. We present the first long-read-based de novo genome assembly of a Manila clam, and a RNA-Seq multi-tissue analysis of 15 females and 15 males. The highly contiguous genome assembly was used as reference to investigate gene expression, alternative splicing, sequence evolution, tissue-specific co-expression networks, and sexual contrasting SNPs. Differential expression (DE) and differential splicing (DS) analyses revealed sex-specific transcriptional regulation in gonads, but not in somatic tissues. Co-expression networks revealed complex gene regulation in gonads, and genes in gonad-associated modules showed high tissue specificity. However, male gonad-associated modules showed contrasting patterns of sequence evolution and tissue specificity. One gene set was related to the structural organization of male gametes and presented slow sequence evolution but high pleiotropy, whereas another gene set was enriched in reproduction-related processes and characterized by fast sequence evolution and tissue specificity. Sexual contrasting SNPs were found in genes overrepresented in mitochondrial-related functions, providing new candidates for investigating the relationship between mitochondria and sex in DUI species. Together, these results increase our understanding of the role of DE, DS, and sequence evolution of sex-specific genes in an understudied taxon. We also provide resourceful genomic data for studies regarding sex diagnosis and breeding in bivalves.
Turbulent diffusion of large solids in a protoplanetary disc

We study the turbulent diffusion of solids in a protoplanetary disc, in order to discriminate between two existing analytical models of the turbulent diffusion process. These two models predict the same radial turbulent diffusion coefficient D p,x for small particles (τ s > 1, where τ s is the dimensionless particle stopping time, closely related to particle radius). The model given by Youdin & Lithwick (YL) takes into account orbital oscillations of the solids, while the other model given by Cuzzi, Dobrovolskis & Champney (CDC) does not. The CDC model predicts D p,x ∼ τ ―1 s for τ s >> 1, but the YL model gives D p,x ~ τ ―2 s . To investigate, we perform 3D, magnetohydrodynamic (MHD) numerical simulations. Turbulence in the disc is generated by the magnetorotational instability. The ATHENA code is used to solve the equations of ideal MHD in the shearing-box approximation, which allows us to model a local region of the disc with the relevant orbital dynamics. Solids are represented by Lagrangian particles that interact with the gas through drag, and are also subject to orbital forces. The aerodynamic coupling of particles to the gas is parametrized by τ s . In one set of simulations, particle displacements along the radial direction are measured in a shearing box without vertical stratification of the gas density. In another simulation, the vertical component of stellar gravity is included, with a Gaussian gas density vertical profile, but the particle motion is restricted to fixed planes of constant height z. In both cases, the radial diffusion coefficient as a function of stopping time τ s is in very good agreement with the YL model. To study particle vertical diffusion, we use the unstratified shearing box, in which we allow the effects of vertical gravity and turbulence on the particles to balance out, resulting in particle layers whose scaleheight varies approximately as τ ―1/2 s . Based on this result and YL, we calculate a vertical diffusion coefficient D p,z that, in the limit τ s >> 1, varies as τ ―2 s , similarly to radial diffusivity.
Effects of Concurrent Resistance and Endurance Training Using Continuous or Intermittent Protocols on Muscle Hypertrophy: Systematic Review With Meta-Analysis

Abstract Monserdà-Vilaró, A, Balsalobre-Fernández, C, Hoffman, JR, Alix-Fages, C, and Jiménez, SL. Effects of concurrent resistance and endurance training using continuous or intermittent protocols on muscle hypertrophy: Systematic review with meta-analysis. J Strength Cond Res 37(3): 688–709, 2023—The purpose of this systematic review with meta-analysis was to explore the effects of concurrent resistance and endurance training (CT) incorporating continuous or intermittent endurance training (ET) on whole-muscle and type I and II muscle fiber hypertrophy compared with resistance training (RT) alone. Randomized and nonrandomized studies reporting changes in cross-sectional area at muscle fiber and whole-muscle levels after RT compared with CT were included. Searches for such studies were performed in Web of Science, PubMed, Scopus, SPORTDiscus, and CINAHL electronic databases. The data reported in the included studies were pooled in a random-effects meta-analysis of standardized mean differences (SMDs). Twenty-five studies were included. At the whole-muscle level, there were no significant differences for any comparison (SMD < 0.03). By contrast, RT induced greater type I and type II muscle fiber hypertrophy than CT when high-intensity interval training (HIIT) was incorporated alone (SMD > 0.33) or combined with continuous ET (SMD > 0.27), but not compared with CT incorporating only continuous ET (SMD < 0.16). The subgroup analyses of this systematic review and meta-analysis showed that RT induces greater muscle fiber hypertrophy than CT when HIIT is included. However, no CT affected whole-muscle hypertrophy compared with RT.
Tachyplesin I and its derivatives: A pharmaco-chemical perspective on their antimicrobial and antitumor potential

ABSTRACT Introduction Increasing evidence suggests that intratumor microbiota are an intrinsic component in the tumor microenvironment across multiple cancer types, and that there is a close relationship between microbiota and tumor progression. Therefore, how to address the interaction between bacteria and malignances has become a growing concern. Tachyplesin I (TPI), a peptide with dual antimicrobial and antitumor effects, holds great promise as a therapeutic alternative for the aforementioned diseases, with the advantage of broad-spectrum activities, quick killing efficacy, and a low tendency to induce resistance. Areas covered This review comprehensively summarizes the pharmacological mechanisms of TPI with an emphasis on its antimicrobial and antitumor potential. Furthermore, it presents advances in TPI derivatives and gives a perspective on their future development. The article is based on literature searches using PubMed and SciFinder to retrieve the most up-to-date information of TPI. Expert opinion Bacterial infections and cancer both pose a serious threat to health due to their symbiotic interactions and drug resistance. TPI is anticipated to be a novel agent to control pathogenic bacteria and various tumors through multiple mechanisms of action. Indeed, the continuous advancements in chemical modification and innovative applications of TPI give hope for future improvements in therapeutic efficacy.
Transcription Factor–Forced Astrocytic Differentiation Impairs Human Glioblastoma Growth In Vitro and In Vivo

Abstract Direct cellular reprogramming has recently gained attention of cancer researchers for the possibility to convert undifferentiated cancer cells into more differentiated, postmitotic cell types. While a few studies have attempted reprogramming of glioblastoma (GBM) cells toward a neuronal fate, this approach has not yet been used to induce differentiation into other lineages and in vivo data on reduction in tumorigenicity are limited. Here, we employ cellular reprogramming to induce astrocytic differentiation as a therapeutic approach in GBM. To this end, we overexpressed key transcriptional regulators of astroglial development in human GBM and GBM stem cell lines. Treated cells undergo a remarkable shift in structure, acquiring an astrocyte-like morphology with star-shaped bodies and radial branched processes. Differentiated cells express typical glial markers and show a marked decrease in their proliferative state. In addition, forced differentiation induces astrocytic functions such as induced calcium transients and ability to respond to inflammatory stimuli. Most importantly, forced differentiation substantially reduces tumorigenicity of GBM cells in an in vivo xenotransplantation model. The current study capitalizes on cellular plasticity with a novel application in cancer. We take advantage of the similarity between neural developmental processes and cancer hierarchy to mitigate, if not completely abolish, the malignant nature of tumor cells and pave the way for new intervention strategies.