Miracle-dz/UniFAR-FTUs huggingface dataset:
Failed endometrial metabolite synthesis contributes to subfertility in women with unexplained infertility

DOI: 10.4328/ACAM.20821 Received: 2021-08-18 Accepted: 2021-09-21 Published Online: 2021-09-25 Corresponding Author: Cemil Karakus, Vocational School of Health Services, Beykent University, Istanbul, Turkey. E-mail: drckarakus@gmail.com P: +90 532 348 30 33 Corresponding Author ORCID ID: https://orcid.org/0000-0003-3389-7662 Abstract Aim: This study compares endometrial metabolite signal intensities of patients diagnosed with unexplained infertility (UEI) with those of fertile women. Material and Methods: A total of 20 patients diagnosed with UEI and 20 fertile women with at least two children were included in the study. UEI patients were matched with the fertile group in terms of age and BMI. UEI was defined as the absence of conception despite 12 months of unprotected intercourse, not explained by anovulation. Endometrial spectroscopy was applied to the women in both groups in the mid-luteal phase of the cycle. The endometrial signals of choline (Cho), creatine (Cr), lactate, and lipids were measured in units and denominated in parts per million. Results: All patients in both groups underwent successful spectroscopy and the main metabolites of Cho, Cr, lactate, and lipids were recorded. Cho (2.93±1.03 vs. 3.22±2.04, p<0.05) and Cr (2.33±1.30 vs. 2.76±1.43, p<0.01) metabolite signal intensities were found to be significantly lower in UEI patients compared to fertile controls. Lactate (0.56±0.11 vs. 0.62±0.30, p>0.66) and lipid (0.70±0.02 vs. 0.78±0.61, p>0.54) signal intensities were found to be similar between the groups. Discussion: Decreased Cho and Cr signals, which are physiological indicators of endometrial function, may be the possible cause of subfertility in UEI patients.
Economic Opportunity, Drug Overdose Mortality, and Disability

This study investigates the role of fading economic opportunity in two significant trends faced by working-age adults in the United States: worsening mortality (particularly from drug overdoses) and rising rates of application to the Social Security Disability Insurance (SSDI) and Supplemental Security Insurance (SSI) programs. Specifically, we examine the relationship between commutingzone-level exposure to automation—which has led to reductions in labor-market opportunities in historically important sectors such as manufacturing—and county-level mortality and SSI/SSDI application rates for 18–65-year-olds. Using exogenous variation in automation (as measured by the penetration of industrial robots per 1,000 workers) to support causal inference, we find that increases in automation over the period 1993–2007 led to substantive increases in drug overdose mortality for both men and women, particularly in manufacturing counties. The largest impacts were for 30–44 and 45–54-year-old men living in manufacturing counties, for whom we also find significant increases in mortality from all causes and suicide. We also find strong effects of automation on SSDI and SSI applications, driven by applications that were ultimately denied. Collectively, the average increase in automation exposure can account for 12% of the rise in drug overdose mortality between 1993 and 2007, and 22% and 12% of the rise in SSI and SSDI applications, respectively, between 2000 and 2007. We also find meaningful heterogeneity in the relationship between automation and drug overdose mortality: counties with higher levels of social capital and higher shares of college graduates experienced fewer drug overdose deaths for similar levels of exposure to automation, as did counties in states with more generous Medicaid programs. Counties in states with lower rates of opioid prescriptions also experienced larger increases in mortality from automation. Opportunity, Mortality, and Disability 3
A Prospective Study on the Surgical Management of Closed Lisfranc Injury by Various Modalities

Introduction: The Lisfranc injuries are the injuries of one or more metatarsals that are displaced with respect to the tarsus. The incidence of such injuries is rare as compared to other fractures. However, they carry a high risk of morbidity and economic implications. We in the current study tried to evaluate different treatment modalities for Lisfranc injuries reporting to our Hospital. Methods: This cross-sectional study was conducted in the Department of Orthopedics Mahatma Gandhi Memorial Hospital, Kakatiya medical college, Warangal. The sample size of n=60 patients presented with Lisfranc injury was treated by using K-wires, screws, and plates. Results: A total of n=60 cases were included and studied during the period. The cases were equally K-wire 33.33%, Screw 33.33% cases, and plate fixation in 33.33% cases. The functional outcomes of the study revealed Excellent outcomes in 46.67% of cases out of which plate fixations achieve better outcomes. Poor outcomes were more commonly noted in the Kwire fixations and no case of poor outcome was noted in the plate fixations. Conclusion: Percutaneous screw fixation is an effective and relatively simple method of treating TMT trauma specially Myerson type B (partial incongruous) injuries and fracturedislocation. In our study, we found that both K wire and screw fixation were adequate in allowing an acceptable anatomical reduction until the healing occurred although the overall outcome by dorsal plate was better with lesser complications
Influence of Transversal Acoustic Excitation of the Burner Approach Flow on the Flame Structure

Modern large gas turbines for power generation have multiple burners, which are distributed around the circumference of the engine and which generate flames in combustors of either annular or can-annular geometry. In both cases, considering only the axial modes has proven to be insufficient for the assessment of the thermoacoustic stability. An adequate analysis requires consideration of the circumferential acoustic coupling generated by the acoustic field in the upstream and downstream annuli and the open passages between the cans, respectively. As in annular combustors, the particularly critical eigenmodes with low frequencies are predominantly of circumferential nature; the stability of annular combustors is often governed by the onset of circumferential acoustic oscillations. To determine the influence of these circumferential acoustic modes on the dynamic flame behavior, a new single burner test rig was developed. The unique acoustic properties of the test rig allow the exposure of a single swirl burner to a two-dimensional acoustic field that resembles the circumferential mode in an annular combustor. Measurements were performed for axial as well as transversal excitation of the burner and the combination of both. To investigate the dynamic flame structure, phase-resolved flame images have been evaluated in terms of amplitude and phase distribution. Under transversal excitation, the flame structure becomes highly asymmetrical. A region of higher OH * intensity is generated in the combustion chamber, which rotates with the excitation frequency. From phase-resolved particle image velocimetry (PIV) measurements of the isothermal flow, it is concluded that the transversal excitation modulates the swirl generation leading to an asymmetrical velocity distribution in the burner nozzle and the combustion chamber.
The Filtering Effect of Face Masks in their Detection from Speech

Face masks alter the speakers’ voice, as their intrinsic properties provide them with acoustic absorption capabilities. Hence, face masks act as filters to the human voice. This work focuses on the automatic detection of face masks from speech signals, emphasising on a previous work claiming that face masks attenuate frequencies above 1 kHz. We compare a paralinguistics-based and a spectrograms-based approach for the task at hand. While the former extracts paralinguistic features from filtered versions of the original speech samples, the latter exploits the spectrogram representations of the speech samples containing specific ranges of frequencies. The machine learning techniques investigated for the paralinguistics-based approach include Support Vector Machines (SVM), and a Multi-Layer Perceptron (MLP). For the spectrograms-based approach, we use a Convolutional Neural Network (CNN). Our experiments are conducted on the Mask Augsburg Speech Corpus (MASC), released for the Interspeech 2020 Computational Paralinguistics Challenge (COMPARE). The best performances on the test set from the paralinguistic analysis are obtained using the high-pass filtered versions of the original speech samples. Nonetheless, the highest Unweighted Average Recall (UAR) on the test set is obtained when exploiting the spectrograms with frequency content below 1 kHz.
Gamification: A Tool To Enhance Employee Engagement And Performance

The purpose of this research is to examine the impact of gamification on employee engagement and work performance among employees working in IT Multinationals in Malaysia. And to examine the mediating effect of employee engagement on the relationship between gamification and employee performance. Finally, to test the moderating effect of gamification on the relationship between employee engagement and employee performance. Data was collected using a self-rating Likert-Scale questionnaire with a rating scale from 1-5, denoting 1 is strongly disagree, and 5 denotes strongly agree. A Sample of 220 employees were selected using simple random probability sampling of those employees working in IT Multinationals. Data were analyzed using confirmatory factor analysis and structure equation modelling under bootstrapping methods via AMOS22. The result shows that gamification does not directly affect employee performance among the IT Multinational in Malaysia. However, gamification has a significant and positive effect on employee engagement. Also, the result shows that employee engagement is a full mediator and gamification has a moderating effect on the relationship between employee engagement and performance. This study is useful for Human Resource Development intervention through effective training programs to enhance gamification to boost engagement and performance. Through effective gamification with sensitivity, creativity and implemented it within the organization can cultivate highly competitive culture among the staff, resulting in high employee performance through employee engagement. This finding shows that employee engagement is very important to realize the benefit of gamification to foster employee performance.
Individual Characteristics of Artisan Gold Miners and Their Savings Habits in Rural Zimbabwe: Case of Umzingwane District

Quick Response Code Abstract: The aim of the study was to evaluate the individual characteristics of artisan gold miners and their savings habits in rural Zimbabwe using Umzingwane district as a case study. The study used questionnaires to gather data from 350 artisan gold miners with operations in ward 3, 14 and 20 of Umzingwane district. Purposive sampling technique was adopted. The study revealed that although artisan gold mining in Umzingwane district is dominated by men, women also practice artisan gold mining. The study found that the many artisan gold miners in Umzingwane district have no formal bank accounts and were relying on informal savings methods such as Rotating Saving and Credit Schemes (ROSCAs) and savings from homes . The study revealed that factors such as training and education on savings, diversified sources of income, age of an artisan miner and substance use had no significant impact on savings by artisan gold miners. Income levels of artisan gold miners were found to have a positive impact on savings. Number of dependents, level of education and independent financial decisions among artisan gold miners had a negative impact on savings . The study recommends that artisan gold miners should be encouraged to join savings groups such as Internal Savings and Lending Schemes and be connected with formal banking services. Artisan gold miners should also diversify their sources of income so as to have multiple income sources which will foster their resilience to financial shocks.
Percutaneous Fixation of Distal Radius Fracture using kapandji Technique: A comprehensive Review

Distal radius fracture is a very common injury representing 17.5% of all fractures seen in the emergency room. However, the most effective treatment is still unclear and controversially debated. For ten years, we have been facing a true revolution by the increasing use of open reduction and fixation by volar locking plates as an alternative to previous less invasive treatment such as closed reduction and percutaneous kwire pinning. Several meta-analyses have compared the clinical results after closed reduction and percutaneous pinning and volar locking plate fixation. Volar locking plate fixation achieves better early functional recovery, better radiological outcomes and less minor complications. However, long-term results were similar for both fixation methods. In addition, worse radiological outcomes and more minor complications after closed reduction and percutaneous pinning seem not to be clinically relevant. Interestingly, volar locking plate fixation continues to be a more dominant treatment method compared to percutaneous pinning in operative care of distal radius fractures. Surgeon characteristics such as age, profession as well as location and type of the clinic seem to play a role in the decision for the surgical treatment method. It appears that implant cost plays a minor role in treatment choice between closed reduction and percutaneous pinning and volar locking plate fixation.
The presence of a circadian rhythm in pulse arrival time and its application for classifying blood pressure night-time dip

Circadian rhythms of blood pressure (BP) have key diagnostic significance in the assessment of hypertension. The night-time dip or rise in BP (10-20% decrease or increase compared to daytime BP), for example, has been shown to be a strong indicator for cardiovascular disease. However, current methods for assessing the circadian rhythms of BP can be disruptive to sleep, work, and daily activities. Pulse arrival time (PAT) has been suggested as a surrogate measure of BP. This work investigates the presence of a circadian rhythm in PAT and evaluates its application to classify nocturnal BP dip or rise. 769 patients who were discharged home from the ICU were selected from the MIMIC database. Our results show a clear and observable circadian rhythm of PAT that is strongly inversely correlated with BP (r = −0.89). The ratios between nocturnal and diurnal changes in PAT accurately classifies an individual as a nocturnal BP dipper (AUC = 0.72) or a riser (AUC = 0.71). Clinical Relevance—This work shows that you can accurately assess an individuals’s circadian rhythm of BP using PAT.
Investigating the impact of Covid-19 pandemic on stock markets: Evidence from global equity indices

This paper aims to examine the impact of Covid-19 pandemic on stock markets. This paper also analyses the stock market cointegration of selected global equity indices that performed better and have a quick speed of recovery during the pandemic. This paper also questions how increasing uncertainty and volatility deters investors ' perception of the diversification of equity investments. The dataset for the selected 12 global equity indices has been used from Thompson Reuters's EIKON database in a given period of time between 2010 and 2021. This paper employs Vector Error Correction Models to assess the relationship among the selected global equity indices. Findings demonstrate that (i) there is an adverse impact of Covid-19 on the Global Equity markets, (ii) there is a clear sign of cointegration in global equity indices, (ii) investors can benefit from investing in particular equity indices that have exhibited quick speed of recovery from the pandemic records lows. The findings finally provide a strong foundation for constructing a resilient equity portfolio in a highly uncertain market environment.
Investigation of the Role of Serum Matrix Gla-Protein as a Biomarker of Calcific Aortic Valve Disease

Background: Calcific aortic valve disease (CAVD) is a major contributor to cardiovascular morbidity and mortality. Circulating total uncarboxylated Matrix γ-carboxyglutamate (Gla) protein (t-ucMGP) is a promising biomarker for rapid screening of subjects prone to cardiovascular calcification who may need more invasive vascular diagnostics. Preliminary data show that low t-ucMGP levels are indicative for prevalent vascular calcification. Hence, the aim of our study was to investigate the possible role of circulating t-ucMGP as a biomarker may help in identification patients with CAVD, taking into consideration that CAVD is a form of vascular calcification. Methods & Materials: We analyzed serum t-ucMGP levels by enzyme-linked immunosorbent assay (ELISA) in 50 patients with echocardiographically proven CAVD and 21 control subjects. Results: Serum t-ucMGP levels were significantly lower in patients with CAVD (29.29±12.18 nmol/l) compared to the control group (36.84±21.79 nmol/l, p = 0.003). Conclusion: Serum t-ucMGP may help as a noninvasive biomarker for identification of these patients.
Influence of Mineral Admixtures on Early-Age Autogenous Shrinkage of High-Performance Concrete

The influence rules of the mineral admixtures containing fly ash, ground slag and silica fume on the early-age autogenous shrinkage of high-performance concrete have been discussed in this paper. According to the research results, fly ash mixture can substantially decrease the early-age autogenous shrinkage of high-performance concrete, while the silica fume will increase the autogenous shrinkage. Meanwhile the influence of ground slag on autogenous shrinkage is related to its fineness and admixture amount. Generally, it is believed that when the fineness of the fly ash is higher than 4000cm2/g, the autogenous shrinkage will increase with the increasing admixture amount. The double admixture or multi-admixture of fly ash or ground slag is better for reducing the early-age autogenous shrinkage of concrete than the single-admixture. The early-age autogenous shrinkage of concrete occurs in distinctive linear dependence with the three types of mineral admixtures.
The Modelling of Operational Risk: Experience with the Analysis of the Data Collected by the Basel Committee

Since 2001, the Risk Management Group of the Basel Committee has been performing specific surveys of banks' operational loss data. The second loss data collection was launched in the summer of 2002: The 89 banks participating in the exercise provided the Group with more than 47,000 observations, grouped by eight standardised Business Lines and seven Event Types. The objective of this paper is to increase the level of understanding of operational risk within the financial system, by exploring the statistical behaviour of those data and going on to derive bottom-up capital charge figures and Gross Income related coefficients for the Business Lines envisaged in the revised framework of the Capital Accord. The work aims, first of all, to compare the sensitivity of conventional actuarial distributions and models stemming from the Extreme Value Theory in representing the highest percentiles of the data sets: The exercise shows that the extreme value model, in its Peaks Over Threshold representation, explains the behaviour of the operational risk data in the tail area well. Then, measures of severity and frequency of the large losses are gained and, by a proper combination of these estimates, a bottom-up operational risk capital figure is computed for each Business Line. Finally the contributions of the expected losses to the capital figures are evaluated and the relationships between the Business Lines capital charges and the corresponding average level of Gross Incomes are determined and compared with the current coefficients envisaged in the simplified approaches of the regulatory framework. To the end of promoting the development of a pragmatic and effective dialogue on the operational risk measurement issues between regulators and institutions in the course of the implementation of the new Capital framework, feedback from academics and practitioners on the topics dealt with in the paper is welcome. Specifically, the statistical methodologies implemented to model the data and the outcomes of the analysis, in terms of the capital charges and coefficients of the Business Lines, are the topics on which comments should be focused. For assistance in the feedback process and in order to submit comments, please refer to the procedures set by your country's competent national supervisory authority or central bank. Comments should also be sent, preferably via e-mail, to the author.
Learning Outcomes from Business Simulation Exercises: Challenges for the Implementation of Learning Technologies.

Purpose – High order leadership, problem solving skills, and the capacity for innovation in new markets, and technologically complex and multidimensional contexts, are the new set of skills that are most valued by companies and employers alike. Business simulation exercises are one way of enhancing these skills. This article aims to examine the capacity of business simulations to deliver the learning outcomes they have the potential to achieve, and the challenges faced in implementing these technologies.Design/methodology/approach – A literature of the learning outcomes from business simulations, and critical assessment of the challenges and problems involved in the implementation of learning technologies.Findings – Traditionally, postgraduate business education programs have adopted the functional silos that provide the organizational framework for the design of the curriculum. Business problems rarely present themselves in the compartmentalized silo supply‐driven disciplinary framework. The question of .
Macular Microcirculation after Rhegmatogenous Retinal Detachment Repair Evaluated by OCT-Angiography

In the process of rhegmatogenous retinal detachment (RRD), retinal homeostasis may be adversely affected with resultant modifications in retinal and choroidal tissue. Hypoxia and nutrient deprivation along with inflammation at the detached retina may lead to morphological and microvascularity alterations. These changes imply that the functional status of the macula may not be entirely restored despite anatomical repair [1-8]. OCTAngiography (OCT-A) provides depth-resolved vascular information in a non-invasive procedure producing in situ representation of retinal and choroidal circulation, thus enabling physicians to examine foveal microstructure in detail. Interestingly, microcirculation changes in each capillary network including superficial capillary plexus (SCP), deep capillary plexus (DCP), intermediate capillary plexus (ICP) and choriocapillary plexus (CCP) seem to occur in a distinct way dependent on their location and tolerance to tissue hypoxia. Retinal microvasculature of the two capillary plexuses (SCP and DCP) and choriocapillary network are evaluated in detail, while ICP is not always included in most studies due to projection artifact [911]. Notably, the currently available evidence concerning potential macular alterations as seen on OCT-A after RRD repair has stirred controversy as the results of the studies have not been unequivocally confirmed [12-31].