Miracle-dz/UniFAR-FTUs huggingface dataset:
Bax Targeted by miR-29a Regulates Chondrocyte Apoptosis in Osteoarthritis

Osteoarthritis (OA) is a chronic degenerative joint disease, where chondrocyte apoptosis is responsible for cartilage degeneration. Bax is a well-known proapoptotic protein of the Bcl-2 family, involved in a large number of physiological and pathological processes. However, the regulation mechanisms of Bax underlying chondrocyte apoptosis in OA remain unknown. In the present study, we determined the role of Bax in human OA and chondrocyte apoptosis. The results showed that Bax was upregulated in chondrocytes from the articular cartilage of OA patients and in cultured chondrocyte-like ATDC5 cells treated by IL-1β. Bax was identified to be the direct target of miR-29a by luciferase reporter assay and by western blotting. Inhibition of miR-29a by the mimics protested and overexpression by miR-29a inhibitors aggravated ATDC5 apoptosis induced by IL-1β. These data reveal that miR-29a/Bax axis plays an important role in regulating chondrocyte apoptosis and suggest that targeting the proapoptotic protein Bax and increasing expression levels of miR-29a emerge as potential approach for protection against the development of OA.
Hunting Practices Among the Indigenous “Truká” in the Semiarid Region of Brazil

This paper aims to provide information on hunting in the Semi-arid Northeast counting the hunting practices of the Truká Indigenous people. These pieces of information were obtained through interviews, using semistructured questionnaires with fifty-five Indigenous hunters, distributed in four Truká villages located in the states of Bahia and Pernambuco. Thirty-nine poultries, thirteen mammals, and seven reptiles commonly captured the Truká have been cited. Out of the total number, forty-five (42.3%) were used for feeding. Species used as pets (n=20), in magic rituals (n=1), in traditional medicine (n=11), in local handicraft (n=23) and in control hunting (n=6) have also been quoted. Among those species, only one is listed as endangered, to say, Anodorhynchus leari, and one vulnerable, Leopardus tigrinus. Among the interviewees, the common hunting techniques are trap, hatch, pitfall, lasso, hunting net, rifle, slingshot, hook, besides handgrip and dog hunting. The awareness of local perception in the usage of wild fauna is fundamental for decision making in the elaboration of projects for the conservation and management of local fauna, aiming both the maintenance and the continuity of access to this natural resource.
Prevention and management of respiratory disease in young people with cerebral palsy: consensus statement

Respiratory illness is the leading cause of mortality in children with cerebral palsy (CP). Although risk factors for developing chronic respiratory illness have been identified, comprehensive clinical care recommendations for the prevention and management of respiratory illness do not currently exist. We invited over 200 clinicians and researchers from multiple disciplines with expertise in the management of respiratory illness in children with CP to develop care recommendations using a modified Delphi method on the basis of the RAND Corporation–University of California Los Angeles Appropriateness Method. These recommendations are intended for use by the wide range of practitioners who care for individuals living with CP. They provide a framework for recognizing multifactorial primary and secondary potentially modifiable risk factors and for providing coordinated multidisciplinary care. We describe the methods used to generate the consensus recommendations, and the overall perspective on assessment, prevention, and treatment of respiratory illness in children with CP.
The role of corporate environmental commitment and STP on technological talent recruitment in service firms

ABSTRACT In the era of “war for talent” companies should develop effective mechanisms to attract and retain talented workers. In this research, we study how two complimentary company’s mechanisms –firms belonging science and technology parks and corporate environmental commitment –can improve talent recruitment in the field of R&D. Then, a longitudinal study has been carried out from the Spanish Panel of Technological Innovation database (PITEC). Our empirical results show positive individual effects of both firm’s belonging to a science and technology park, as well as corporate environmental practices on technological talent recruitment. Nevertheless, results show an unexpected substitutive effect of both variables on technological talent recruitment.
Effectiveness of cognitive behavioural therapy in reinforcing positive adaption among patients with substance use disorders in the Gaza Strip

ABSTRACT Background: Substance use disorders (SUDs) are a serious threat to health and society, Focusing on the positive personality traits of the addict and reinforcing them through the CBT program is an important factor in addiction treatment. Objectives: The study aims to evaluate the effectiveness of Cognitive Behavioral Therapy (CBT) in reinforcing positive adaption among patients with SUBs in Gaza Strip. Methods: The experimental design was used, 30 male Participants were distributed randomly into two groups: experimental and control (n = 15) per group. Both groups received the standard treatment, while only the experimental group undergoes the CBT program consisting of (16) sessions over 2 months. All of the subjects completed a positive adaption questionnaire before and after the intervention, and 2 months later (follow-up). The required data were collected and analyzed. Results: a statistically significant difference between the two groups in favor of the experimental group in the level of positive adaption. There are statistically significant differences between the grades ranking averages of the experimental group regarding the post and follow-up measurements on the positive adaption scale after 2 months, the p-value < 0.05 in positive-Adaption in posttest and follow-up measurement. Results indicated that CBT was effective in reinforcing positive adaption among patients with SUDs. Conclusions: The study concludes that CBT sessions have been effective and successful in reinforcing the positive adaption among patients with SUD.
Forecasting Disastrous Characteristics of Highway Landslides Using the Material Point Method: A Surcharge-Induced Perspective

Precisely forecasting the disastrous characteristics of landslides can address the optimized preliminary design of the highway landslide stabilization. In this paper, taking the surcharge-induced landslides as an example, we developed the models of the material point method (MPM), a novel meshless numerical method, to calculate the large deformation of the highway landslides, with the affordable computing power. After convincing verification of the MPM model to simulate a surcharge-induced soil landslide, 32 typical postfailure scenarios were analyzed to obtain the highway landslide run-out processes and disastrous characteristics, such as the sliding distance and speed of the leading edge and sliding body morphology. Moreover, linear regression equations of the maximal sliding distance and speed were deduced after verification, to forecast the reasonable avoiding distance. The maximal sliding distance and speed were found to be negatively linearly correlated with the internal frictional angle and cohesion of the soil, and positively linearly correlated with the surcharge and the slope angle, respectively. Optimized preliminary design, of the highways in the mountainous and hilly areas, can be performed based on those insights.
The Effect of Organizational Culture in the Organizational Commitment towards the Development of Talent Management Strategy in the Business Process Outsourcing (BPO) Industry

This study examined the effect of Organizational Culture in the Organizational Commitment of the 298 rank and file employees from the BPOs within the Bonifacio Global City (BGC) and Makati Central Business District. The mixed-method approach was applied in this study which means that both quantitative and qualitative research methods were utilized. On the quantitative approach, the researchers adopted Allen and Meyer’s ThreeComponent Model (TCM) questionnaires in the assessment of the Organizational Commitment while the Cameron and Quinn’s Organizational Culture Assessment Index (OCAI) was utilized in the examination of the Organizational Culture. On the qualitative approach, the researchers constructed structured interview questions as a supplementary to the quantitative results, gauging both the Organizational Culture and OrganizationalCommitment. Results showed that 70.8% of the respondents belong to the youngest age group of 18 to 25 years old. OCAI revealed that the most prevalent Organizational Culture stood in between the Market and Adhocracy.Meanwhile, the respondents’ Affective Commitment varies on the age group. Specifically, those in between 31 to 35 years old exhibited the highest Affective Commitment. Furthermore, respondents with 1-5 years length of stay showed the highest Affective Commitment. Among the three forms of Organizational Commitment, Continuance was found to be the most prevalent among the respondents. Given the results, the two null hypotheses stated were rejected, concluding that the Organizational Culture has a significant effect on the Organizational Commitment, and; there is a significant difference between the demographic profiles of the respondents in terms of the Organizational Commitment.
Developing Indonesian language learning assessments: Strengthening the personal competence and Islamic psychosocial of teachers

Research on the assessment of learning has been carried out by many other researchers, but putting Islamic psychosocial and personal competence as a solution has not been found. This study aimed to develop an assessment of Indonesian Language learning for high school teachers by strengthening Islamic psycosocial and personality competencies. Using the ex post facto approach, by distributing questionnaires to 213 Indonesian Language teachers and analyzed using descriptive and regression. This research results in the mastery of teachers about personality competence, Islamic psychosocial, and the assessment of Indonesian Language is the same as medium mastery. Personality competence and Islamic psychosocial as together are very strong in developing the ability to assessment Indonesian Language learning in high school teachers. Islamic psychosocial is predicted to be able to improve the assessment of Indonesian Language high school teacher learning as well as personality competence. This study concludes that personality’s competences and Islamic psychosocial are very significant in developing the assessment of Indonesian Language high school teacher's in learning. This research contribution strengthens the development of the theory of "teacher performance assesment" in the world of education. For the Department of Education to develop policies to improve the assessment of Indonesian Language learning by conducting Islamic psychosocial and personality competency training for all teachers in Indonesia.
Numerical Analysis of the Detailed Balance of Multiple Exciton Generation Solar Cells with Nonradiative Recombination

In this study, we analyzed the nonradiative recombination impact of multiple exciton generation solar cells (MEGSCs) with a revised detailed balance (DB) limit. The nonideal quantum yield (QY) of a material depends on the surface defects or the status of the material. Thus, its QY shape deviates from the ideal QY because of carrier losses. We used the ideal reverse saturation current variation in the DB of MEGSCs to explain the impact of nonradiative recombination. We compared ideal and nonideal QYs with the nonradiative recombination into the DB of MEGSCs under one-sun and full-light concentration. Through this research, we seek to develop a strategy to maintain MEGSC performance.
Fewer students are benefiting from doing their homework: an eleven-year study

Abstract Performance on homework questions was compared with performance on related exam questions querying the same fact or principle, was used to assess the effect of answering online homework questions on subsequent exam performance. A distinctive pattern of performance was found for some students in which superior performance on online homework questions resulted in poorer exam performance. When assessed over an eleven-year period, for 2433 students in 12 different college lecture courses, the percent of students who did not benefit from correctly answering homework questions increased from 14% in 2008 to 55% in 2017. During the most recent two years of the study, when students were asked how they did their homework, students who benefitted from homework reported generating their own answers and students who reported copying the answers from another source did not benefit from homework.
Reducing work-related burnout among police officers: The impact of job rewards and health-oriented leadership

The aim of the present study was to examine if work effort is associated with burnout among police officers and if job rewards and healthoriented leadership can mitigate the potential adverse effects of high work effort on officers’ mental health. Data were collected in a German police department (n = 573). The results indicated that high work effort was associated with higher levels of burnout while job rewards and health-oriented leadership were associated with lower levels of burnout. Additionally, health-oriented leadership buffered the effects of work effort on police officers’ burnout levels while job rewards showed no buffering effect. The results emphasize the importance of leadership for health promotion in policing.
Precision measurement of the Newtonian gravitational constant

Abstract The Newtonian gravitational constant G, which is one of the most important fundamental physical constants in nature, plays a significant role in the fields of theoretical physics, geophysics, astrophysics and astronomy. Although G was the first physical constant to be introduced in the history of science, it is considered to be one of the most difficult to measure accurately so far. Over the past two decades, eleven precision measurements of the gravitational constant have been performed, and the latest recommended value for G published by the Committee on Data for Science and Technology (CODATA) is (6.674 08 ± 0.000 31) × 10−11 m3 kg−1 s−2 with a relative uncertainty of 47 parts per million. This uncertainty is the smallest compared with previous CODATA recommended values of G; however, it remains a relatively large uncertainty among other fundamental physical constants. In this paper we briefly review the history of the G measurement, and introduce eleven values of G adopted in CODATA 2014 after 2000 and our latest two values published in 2018 using two independent methods.
Is receiving Dislikes in social media still better than being ignored? The effects of ostracism and rejection on need threat and coping responses online

ABSTRACT When posting content in social media, users can feel excluded due to lacking (cyber-ostracism) or negative (cyber-rejection) feedback. Referring to the temporal need-threat model, this study examined the impact that both exclusion experiences have on social media users’ need threat and on their online coping behavior to fortify threatened needs. For this purpose, a pre-registered between-subjects experiment (N = 211) was conducted by manipulating the type of social exclusion on three levels (ostracism; rejection; inclusion). Results indicated that both types of exclusion threatened media users’ needs for belonging, self-esteem, meaningful existence, and control. Compared to ostracized users, rejected ones were more threatened in their needs for belonging and self-esteem, but equally threatened in their needs for meaningful existence and control. Regarding social media users’ coping behavior, ostracized users showed more prosocial behavior, whereas rejected ones rather withdrew from social interactions. Material, code, and data can be found at https://osf.io/3daxq/.
Effects of Interior Color Schemes on Emotion, Task Performance, and Heart Rate in Immersive Virtual Environments

The purpose of this study was to investigate the effects of interior color schemes in immersive virtual environments (IVEs) on emotion, task performance, and heart rate to examine IVEs’ potential for interior color research. Fifty–five (n = 55) student participants were recruited to experience four different colored IVE models (i.e., red, green, blue, and white), and their emotions, heart rate change, and proofreading performances during the immersion were measured. Participants were also asked about their sense of presence after the experience. The findings support the following three hypotheses: (1) IVE interior color schemes affect subject emotion, (2) IVE interior color schemes affect subject task performance as measured through a proofreading exercise, and (3) IVE interior color schemes affect subject heart rate. Specifically, red was perceived as significantly heavier, warmer, more exciting, tenser, and unpleasant. Significantly fewer errors occurred during the white immersion versus the green color scheme when completing the task performance exercise. While heart rate was reduced for each color, significant decreases were detected in the blue, white, and green color scenarios. The majority of participants felt a sense of being there when experiencing the four colored IVE spaces. Based on these results, we conclude that IVE has potential for interior color research to overcome the limitations of traditional color research tools.
Power and Politics in the World-System

While various researchers and practitioners agree that it will be hard to restructure our current global and local systems to adapt to and mitigate climate change, there is unsurprisingly great disagreement in how and if this can be accomplished and on what level(s), or if this is even what needs to be accomplished. These conversations have continued with the introduction of the “Anthropocene. ” The dominant interpretation of the concept poses several solutions, one being national government restructuring to support environmental efforts and encouraging behavioral change. To join conversations that critically evaluate the conceptualization and implications of the Anthropocene with the world-systems perspective, we consider how the effectiveness of national environmental governance in reducing CO2 emissions varies by a country’s position in the global hierarchy. Using two-way fixed effects regression, this article tests how one aspect of this environmental governance, environmentally related taxes as a percentage of total tax revenue impacts CO2 emissions for 75 countries from 2000 to 2011. Given inequities in the global division of labor, which reinforce the dominance of higher-income countries and the exploitation of lower-income countries, we expect the effectiveness of environmental governance to vary tremendously by global position. Our results support the idea that the impact of environmental governance on CO2 emissions varies across countries at different income levels in the world-system, and this is due to external constraints. Such external influence is unsurprisingly neglected in dominant interpretations of the Anthropocene. In line with previous critical research, we argue that these external constraints undermine climate change solutions because they fail to address mutually reinforcing global, political, economic, and environmental inequalities.
The tone at the top: a trickle-down model of how manager anger relates to employee moral behaviour

ABSTRACT The question of how leaders’ expressions of anger influence employees have been the subject of considerable scholarly debate. So far, however, research on the consequences of angry leadership has predominantly focused on the effects of supervisor expressions of anger, neglecting the potential influence of higher-level managerial anger. In this study, we integrate the emotions as social information theory with the adapted elaboration likelihood model to examine how manager anger trickles down across organizational hierarchical levels (i.e., managers, supervisors, and employees) to affect employee moral behaviour. Results of a multi-source field study conducted in Chile demonstrate that perceptions of manager moral behaviour and supervisor servant leadership serially mediate a negative relationship between manager anger and employee moral behaviour. Furthermore, counter to our predictions, trait negative affectivity of supervisors did not moderate the trickle-down relation of manager anger on employee moral behaviour. Our research elucidates the process by which manager anger can “set the tone” in an organization and trickle down across hierarchical levels to predict the moral behaviour of employees.
Inquiry-Based Science Teaching under Construction: Possibilities of Articulations Between Conceptual, Epistemic and Social Domains Within Scientific Knowledge in the Classroom

In this paper, we analyse how a class discursively constructed articulations between the conceptual, epistemic and social domains of scientific knowledge. The first-grade class studied biological aspects of an insect. For data collection and analysis, we use Ethnography in Education as logic of inquiry. Our results indicate that the use of instructional resources, organised around questions, generated different ways of articulation between the three domains, evidenced in the participants’ oral speech. The emphasis on the [epistemic+social] pair has given a more investigative character to the instructional context under construction. We also discuss implications for pedagogical practice and research in science education.
Coherent and incoherent space-charge effects in high-intensity hadron rings

A brief overview is given of the recent work done by the beam-physics group of Hiroshima University on resonant beam instabilities in high-intensity hadron rings. Emphasis is placed upon two essentially different instability mechanisms, namely, coherent and incoherent resonances that occur respectively in the beam core and in the beam tail. On the basis of a semi-empirical coherent resonance condition, a simple rule is introduced to construct a new type of stability map. The proposed diagram enables one to find the optimum operating region of any circular machine in the betatron tune space very easily and quickly.