Miracle-dz/UniFAR-FTUs huggingface dataset:
Reply by Elmaleh-Sachs et al. to Townsend and Cowl, and to Miller et al.

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A comparative evaluation of neurophysiological activity, active tactile sensibility and stereognostic ability of complete denture prosthesis, and implant-supported prosthesis wearer-A pilot study.

AIM The study aimed to evaluate the effect of implant-supported prosthesis in completely edentulous participants in terms of osseoperception ability, neural activity, and stereognostic ability in comparison to removable prosthetic options. MATERIALS AND METHODS A total sample of 18 patients, irrespective of gender and age were allocated into three groups according to the three-treatment protocol (upper and lower complete denture, upper complete denture opposing lower implant-retained overdenture, implant-supported fixed prosthesis in both arches). Four weeks after completion of the treatment procedure active tactile sensibility (ATS) was checked by using varying thicknesses (12, 40, 80, 100, 200 μ) of articulating foils and papers. Functional magnetic resonance imaging (fMRI) was performed to record neurophysiological activity in cerebral cortex in all the participants. Various forms of test pieces (heat cure acrylic resin) were used to evaluate stereognostic ability. Data regarding the neurophysiological activity were analyzed by using Krushkal-Wallis test and p ≤ 0.05 was considered to be statistically significant. Data from stereognostic ability test procedure and ATS were compared by using chi-squared test and p ≤ 0.05 was considered to be statistically significant. RESULTS Statistically significant difference was found in between the articulating foils in terms of true negative responses as the foil thickness increased in participants wearing complete denture in both the arches (p = 0.004) and implant-supported fixed prosthesis in both the arches (p = 0.010). Participants in implant-supported fixed prosthesis group showed significantly more activation in primary motor cortex (right side), somatosensory cortex (left side), angular gyrus (both sides), temporal lobe (left) compared to other groups. No significant difference found in thalamus and premotor cortex region in between the participants of different groups. No statistically significant difference found in between the groups in terms of true responses identifying correct shapes. Mean number of correct responses in stereognostic ability test were 4.16 (83.33%), 3.5 (70%), 3.83 (76.66%) for participants of complete denture group, upper complete denture opposing lower implant retained overdenture group, and implant-supported fixed prosthesis group, respectively. CONCLUSION Primary motor cortex, somatosensory cortex, and other regions of brain were diffusely activated in participants wearing implant-supported fixed prosthesis in both the arches. Less number of false responses were recorded in participants of implant-supported fixed prosthesis group and upper complete denture opposing lower implant-retained overdenture group in ATS test compared to participants wearing complete denture in both the arches.
Toward Building Surge Capacity: Potentially Effective Spatial Configurations in Emergency Departments

Background: Emergency departments (EDs) have been struggling with overcrowding issues for years. Some spatial configurations have been proposed to improve ED performance in facing overcrowding. Despite similarities with mass casualty incidents (MCIs), when demand for care exceeds the capacity, little is documented about the application of the proposed configurations during MCIs to improve surge capacity. Objectives: We aimed to explore the potential of spatial configurations that have been proposed to handle ED overcrowding in daily operations so as to improve surge capacity during MCIs. Methods: Using an online Likert-scale survey, 11 spatial design strategies were rated by ED care teams in terms of their potential to improve surge capacity during MCIs. Results: Responses from 72 participants revealed that establishing an in-house lab was perceived as the most potential strategy, followed by rapid care area, internal waiting rooms, and in-house imaging. In contrast, separate entrance and exit doors, as well as decentralized nurse stations, were perceived as the least potential strategies but also exhibited the most variance in response. Respondents’ comments implied that their choice of in-house ancillary services was primarily to improve communication and to reduce turnaround time and risk of errors. Their choice of rapid care and internal waiting areas related to improved flexibility. Conclusions: Understanding clinicians’ perspectives on potentially effective spatial configurations aids in implementing balanced strategies to better equip EDs to handle overcrowding in daily operations and manage surges during MCIs.
Phytobeneficial traits of rhizobacteria under the control of multiple molecular dialogues

Pseudomonads play crucial roles in plant growth promotion and control of plant diseases. However, under natural conditions, other microorganisms competing for the same nutrient resources in the rhizosphere may exert negative control over their phytobeneficial characteristics. We assessed the expression of phytobeneficial genes involved in biocontrol, biostimulation and iron regulation such as, phlD, hcnA, acdS, and iron‐small regulatory RNAs prrF1 and prrF2 in Pseudomonas brassicacearum co‐cultivated with three phytopathogenic fungi, and two rhizobacteria in the presence or absence of Brassica napus, and in relation to iron availability. We found that the antifungal activity of P. brassicacearum depends mostly on the production of DAPG and not on HCN whose production is suppressed by fungi. We have also shown that the two‐competing bacterial strains modulate the plant growth promotion activity of P. brassicacearum by modifying the expression of phlD, hcnA and acdS according to iron availability. Overall, it allows us to better understand the complexity of the multiple molecular dialogues that take place underground between microorganisms and between plants and its rhizosphere microbiota and to show that synergy in favour of phytobeneficial gene expression may exist between different bacterial species.
Perception of Social Workers on the Psychosocial Issues of End-Stage Renal Disease Patients during COVID-19: A Qualitative Study

ABSTRACT The COVID-19 pandemic has a significant impact on the routine care of patients with chronic illnesses. Patients with existing conditions such as diabetes, and cardiovascular disease are more susceptible to COVID-19 and are likely to experience more severe illnesses. COVID-19 infection leads to adverse clinical outcomes, more severe disease, higher mortality, and poor prognosis in patients with chronic kidney disease. The patient and caregiver would be in extreme distress with the fear of getting infected from the frequent exposure. The present study attempts to explore the perception of social workers on the psychosocial issues of persons with End-Stage Renal Disease during the COVID-19 pandemic period by using social cognitive theory and the social-ecological model as theoretical frameworks. Our study followed a qualitative design that employed a thematic analysis approach. We conducted in-depth telephonic interviews with six social workers in the nephrology setting. Three theme categories emerged as per data analysis. The first was the social worker’s perception of psychosocial issues of patients with End-Stage Renal Disease. The second theme was related to the emerging role of the social worker and the skills acquired during this period and the third theme was the challenges experienced and the resilience of social workers in the nephrology setting. The study shows that patients are in extreme distress as they are more vulnerable to COVID-19 infection and it also highlighted the significance of social work practice in the nephrology setting.
If you build it, will they come? A comparative landscape analysis of ocelot roadkill locations and crossing structures

Wildlife-vehicle collisions can have a substantial influence on the mortality rates of many wildlife populations. Crossing structures are designed to mitigate the impact of road mortality by allowing safe passage of wildlife above or below roads, and connect to suitable areas on both sides of the road. Ocelots (Leopardus pardalis) are a federally endangered felid in the United States, with remnant populations of <80 individuals remaining in the Lower Rio Grande Valley of South Texas. Vehicle collisions are the greatest known source of mortality for ocelots in Texas. Crossing structures designed for ocelot use have been implemented throughout South Texas since the 1990s, however, ocelots rarely use them. We compared landscape characteristics between ocelot crossing structures and ocelot-vehicle collision sites. We quantified the spatial distribution of woody and herbaceous cover types surrounding ocelot crossing structures (n = 56) and ocelot-vehicle collision sites (n = 26) at multiple spatial extents and compared landscape metrics between these location types. The landscape surrounding ocelot crossing structures had 17–22% more open herbaceous cover >1,050 m from the road, and 1.2–5.8 ha larger herbaceous patches >450 m from the road compared to ocelot-vehicle collision sites. Additionally, many crossing structures installed during the 1990’s are situated >100 km away from an extant ocelot population. Results from this study can guide conservation planners to place future road crossing structures in areas more likely to be used by ocelots. Our results also emphasize that reliable scientific data must be used for effective mitigation efforts. In the absence of data, post-installation assessments can improve the placement of future structures.
Incontinence outcomes in women undergoing retropubic mid-urethral sling: a retrospective cohort study comparing Safyre™ and handmade sling

ABSTRACT Purpose This study examined and compared efficacy, safety, satisfaction, and complications of the retropubic Safyre™ sling and a retropubic hand-made synthetic sling (HMS) in a short-, mid- and long-term follow-up. Methods We retrospectively reviewed a prospectively maintained database of women who underwent Safyre™ or HMS between March 7ths 2005 and December 27ths, 2017. Patients had first assessment (7-10 days), second (40-45 days), and third (sixth month) postoperatively. Between September and December 2018, patients who completed at least one year of surgery, received a telephone call. Follow-up compared quartiles of follow-up time to determine complications (Clavien-Dindo), success rates (International Consultation on Incontinence Modular Questionnaire for Urinary Incontinence Short Form – ICIQ-UI SF), and patient satisfaction. Results Three hundred fifty-one patients underwent surgery and 221 (63%) were evaluated after a median of 78.47 (± 38.69) months, 125 (55%) in the HMS, and 96 (45%) in the Safyre™ group. Higher intraoperative bladder injury was observed with Safyre™ (0% vs. 4.2%, p=0.034), and a tendency for urinary retention, requiring indwelling urinary catheter over 24 hours (2.4% vs. 8.3%, p=0.061). Both HMS (p<0.001) and Safyre™ (p<0.001) presented improvements on ICIQ-UI SF. There were no differences in satisfaction, subjective cure rates, ICIQ-UI SF, or complications between groups. Conclusions Both HMS and Safyre™ have similar satisfaction and subjective cure rates, with marked ICIQ-UI SF score improvement. Higher rates of intraoperative bladder injury were seen in patients who received Safyre™ retropubic sling.
Expression of Tissue microRNAs in Ascending Aortic Aneurysms and Dissections

Little is known about the role of serum and tissue mediators in the progression of ascending aortic aneurysms and dissections. We examined how the tissue expression of microRNAs and matrix metalloproteinases (MMPs), as well as the serum levels of osteoprotegerin, adiponectin, and high sensitivity C-reactive protein (hsCRP) are associated with these entities. We enrolled 21 patients with ascending aortic aneurysm, 11 with acute Stanford type A aortic dissection and 18 controls. The serum levels of osteoprotegerin, adiponectin, and hsCRP, as well as the tissue expression of MMPs 2 and 9 and tissue microRNAs 29 and 195 were compared among groups. There was no difference regarding serum osteoprotegerin, adiponectin, and tissue MMP2 and MMP9 levels. hsCRP was higher in the dissection group (P = .03). Tissue expression of microRNA 29 was 2.11-fold higher in the dissection (P = .001) and 2.99-fold higher in the aneurysm group (P < .001), compared with the control group. Tissue expression of microRNA 195 was 2.72-fold higher in the dissection (P < .001) and 2.00-fold lower in the aneurysm group (P = .08), compared with to the control group. These findings support the contribution of microRNAs in the progression of aneurysm formation and dissection, suggesting a role as potential biomarkers and future therapeutic targets.
The effect of slab and transverse beams on the behaviour of full-scale pre-1970's RC beam-column joints

Past research and empirical evidence has shown that beam-column joints play a critical role in the cyclic behaviour of reinforced concrete (RC) structures and that a good understanding of the complex mechanical interactions in beam-column connections is necessary to ensure the desired hierarchy of failure is achieved. Development of such understanding requires specifically designed numerical and experimental studies that depict realistic structures. However, reviews of published experimental literature show that most experimental studies on the seismic behaviour pre-1970’s RC beam-column connections focus on the testing of sub-assemblies without slabs or transverse beams, which are unrepresentative of reality. This paper presents the first part of a study being carried out to shed light on how (and by how much) slabs and transverse beams contribute to the seismic performance of gravity-designed interior beam-column connections, and the consequences of ignoring or wrongly representing this contribution. It presents the results of experiments on three full-scale beam-column joints. One of these test specimens is designed to Eurocode 8 and two are of typical pre-1970’s design, with one specimen containing a slab and transverse beams, whilst the other represents the typical cross-shaped specimen tested in many other studies. The paper also presents preliminary nonlinear three-dimensional finite element (FE) models to complement the experiments, and extend them to look at the case of a pre-1970’s specimen with transverse beams and no slab. As expected, the experimental and numerical results clearly demonstrate that the progression of damage and failure mechanisms in beamcolumn connections with and without slabs and transverse beams differ significantly. The experimental findings also generally confirm inferences from the limited published experimental evidence that the contribution of slabs and transverse beams can be underestimated by current guidelines. These observations have implications when considering common simplifications made in the numerical modelling of RC moment resisting frames when assessing their seismic performance.
Clinical update on psychiatric outcome measurement: what is the purpose, what is known and what should be done about it?

Objective To provide a clinical update on the purposes, evidence-base and recommendations for both clinician and patient-rated outcome measures in psychiatric practice. Conclusions Private and public sector funders have implemented outcome measurement systems in Australian mental healthcare, in order to improve cost-effectiveness. It is important to consider the ultimate aims of outcome measurement from various perspectives in evaluating the evidence-base, as there are a number of measurement dimensions to address. For individual clinicians, the purpose may be to guide treatment-planning, as well as to assess treatment and clinician efficacy. For patients, the purpose is to assess outcomes in terms of their goals for recovery, as well as to evaluate their satisfaction with the care provided, and their healthcare providers. The other orthogonal dimensions of measurement comprise, the proximal to illness measures of symptomatic severity, and the distal measures of disability, which apply to both clinician and patient outcomes. In turn, these measures may be used by healthcare funders in public or private sectors as proxy measures of the cost-effectiveness of psychiatric care provided. Clinical registries linked to service-mapping would provide better data for patients, providers and funders to assess the availability and effectiveness of psychiatric care in Australia.
Phenanthrene stress response and phytoremediation potential of free-floating fern Azolla filiculoides Lam.

Abstract In this study, the potential of Azolla filiculoides, a freshwater fern species, on phenanthrene phytoremediation and biodegradation was investigated. Furthermore, the effect of phenanthrene on growth performance, photosynthetic activity and biosynthesis, and accumulation of secondary metabolites of A. filiculodes were evaluated. Plants were grown in a nitrogen-free Hoagland and exposed to different phenanthrene concentrations (0, 1, 5, and 10 mg/L). Exposure to 10 mg/L phenanthrene caused a significant reduction (42%) in Azolla filiculoides growth compared to control on day 14. The photosynthetic pigment content of A. filiculoides treated with 1 and 5 mg/L was almost the same as the control, while 10 mg/L phenanthrene was significantly reduced. In comparison to unplanted controls, the biodegradation percentages obtained from the planted growth medium were found to be 88, 69, and 60%, respectively, for the application of 1, 5, and 10 mg/L phenanthrene. Data on plant growth, photosynthetic pigments, secondary metabolite contents, and biodegradation percentages indicated the tolerance level and the effective phytoremediation potential of A. filiculoides for phenanthrene was <10 mg/L. The results indicated that A. filiculoides is highly effective in phytoremediation of low concentrations of phenanthrene pollution in a short time. NOVELTY STATEMENT We explored the phenanthrene phytoremediation potential of freshwater fern Azolla filiculoides for the first time. Exposure to high phenanthrene induced accumulation of secondary metabolites, while reducing plant growth and photosynthetic pigment content. A. filiculoides is highly effective in phytoremediation of phenanthrene pollution at low concentrations in a short time. Biodegradation (≥60%) promoted by A. filiculoides indicates that this plant is a promising candidate for phenanthrene phytoremediation in aquatic environments.
A critical review of oliceridine injection as an IV opioid analgesic for the management of severe acute pain

ABSTRACT Introduction Oliceridine is a G protein-selective (biased) agonist at the μ-opioid receptor, with less recruitment of β-arrestin-2, a signaling pathway associated with opioid-related adverse events. Nonclinical evidence showed that oliceridine elicits a rapid systemic analgesic effect while attenuating opioid-related adverse events. Areas covered Three pivotal studies in patients with moderate-to-severe acute pain, including two randomized, double-blind, placebo- and morphine-controlled efficacy studies following either orthopedic surgery-bunionectomy or plastic surgery-abdominoplasty; and an open-label safety study following a surgical procedure or due to a medical condition. Expert opinion Poorly controlled acute postoperative pain is associated with poorer recovery, longer hospitalization, increased complications, and worse healthcare outcomes. Recently, oliceridine intravenous injection was approved for use in adults for the management of acute pain severe enough to require an intravenous opioid analgesic and for whom alternative treatments are inadequate. Introduction of this new IV opioid provides a valuable option to manage postoperative pain.
Spirulina therapeutic potentiality in polycystic ovarian syndrome management using DHEA-induced rat model.

OBJECTIVE: The most prevalent endocrinopathy in women is polycystic ovarian syndrome (PCOS). Multiple gene abnormalities like Ar, Cyp19a1, Hsd3b1, Srd5a1, Bcl-2, and Bax genes are associated with PCOS. Herein, the PCOS model was induced by oral administration of dehydroepiandrosterone (DHEA). Metformin (Met) is one of the most common drugs affecting the most relevant genes involved in PCOS development but with unwanted side effects. Natural treatments have been known for their safer effects. Spirulina (SP) is a type of blue-green algae that contains nutrients and compounds that would treat PCOS and lower the possible side effects of Met in combination therapy. We aim to evaluate the clinical effectiveness and safety of SP on PCOS by multi confirmatory tests and to demonstrate its effects on regulating the expression of multiple genes that are responsible for the occurrence of PCOS in comparison to Met. MATERIALS AND METHODS: Herein, sixty adult female Wistar albino rats were subdivided into equal six groups with 10 rats in each group. All drugs were given orally once daily for one month. The expression of Ar, Cyp19a1, Hsd3b1, Srd5a1, Bcl-2, and Bax genes, were examined by quantitative real-time PCR (qRT-PCR). RESULTS: The present study showed that SP has a remarkable effect on the reduction of the development of PCOS by regulating the expression of the examined genes. As a result, it may be a useful therapy alternative for PCOS complications, symptoms, and infertility as well. CONCLUSIONS: Collectively, SP is considered a promising therapeutic drug in the treatment of PCOS-like symptoms induced by DHEA. Graphical Abstract https://www.europeanreview. org/wp/wp-content/uploads/Graphical-Abstract.tif.