Miracle-dz/UniFAR-FTUs huggingface dataset:
Signi cance of accurate hilar and intrapulmonary lymph node examination and prognostication in stage IA-IIA non-small cell lung cancer, a retrospective cohort study

Wenyu Zhai Sun Yat-sen University Cancer Center Fangfang Duan Sun Yat-sen University Cancer Center Yuzhen Zheng A liated Cancer Hospital & Institute of Guangzhou Medical University Qihang Yan Sun Yat-sen University Cancer Center Shuqin Dai Sun Yat-sen University Cancer Center Tao Chen The People's Hospital of Chaozhou Jianlong Chen The Second People's Hospital of Shantou Junye Wang (  jywangmed@163.com ) Sun Yat-sen University Cancer Center
Hierarchical Learning of Reactive Behaviors in an Autonomous Mobile Robot Using Stochastic Hillclimbing

Traditionally, the task of developing a sensorimotor control architecture for a situated autonomous robot was left to the human programmer of the robot. Prewiring robot behaviors by hand however becomes increasingly complex for robots with large number of sensors and e ectors, especially when they are performing sophisticated tasks that involve continuous interaction with the encompassing environment. In such cases, it is our belief that considerable simpli cation can be achieved by employing a hierarchical behavior-based decomposition of the control architecture as originally suggested by Brooks [2]. In addition, it is desirable in many cases to endow the robot with the ability to adapt its constituent behaviors on-line in response to environmental stimuli by allowing it to autonomously learn the transfer function mapping sensory input into motor commands. For even moderately complex tasks and/or robots, the high dimensionality of the sensorimotor space makes learning di cult. One commonly used approach to make robot learning feasible despite the high dimensionality of the sensory space is to run the learning algorithm on a simulated environment (for example, [8]). However, in many situations, it is di cult or impossible to gather enough knowledge about the robot and its environment to build an accurate simulation. Moreover, some physical events, such as collisions, are extremely di cult to simulate even when there is complete knowledge. For these reasons, we believe that in order for the learned skills to be applicable by the physical robot in its environment, all the learning and experimentation has to be carried out by the embodied physical robot itself. However, using a real robot has some drawbacks: given the slowness of real world experimentation and the limited computing power typically available in autonomous mobile robots, for the learning algorithms to be successfully applied, it is crucial that they converge within a reasonable number of trials and that they don't require large amounts of memory. The technique we present in this paper satis es both requirements. This paper describes an autonomous mobile robot that employs a simple sensorimotor learning algorithm at three di erent behavioral levels to achieve coherent goal-directed behavior. In particular, the robot solves the task of navigating to a goal destination (indicated by an infrared beacon) within an obstacle-ridden environment by using a set of learned behaviors for obstacle detection, obstacle avoidance, and beacon following. The behaviors themselves are learned individually by using a simple stochastic hillclimbing strategy that has recently been shown [4] to yield results that are comparable to those obtained by using more complicated techniques such as genetic algorithms [3].
Boundary of a Gaussian process

: We study the boundary behavior of a Gaussian process. There is essentially no diﬀerence in maximal displacement between a Gaussian process and its reﬂected counterpart. We provide two proofs of this fact, one via a soft argument on the dependence of two-sided extremal particles in a Gaussian process and the other based on direct computations. The asymptotics of minimal displacement is also given
eTryOn – Virtual try-ons of garments enabling novel human fashion interactions Core functionalities of the mobile application and software for the self-scanning application

This deliverable presents the work done to increase the attractiveness and accuracy of the 3D body models. This is achieved by implementing a new body space, evaluating different matching approaches and developing an improved segmentation algorithm to extract body silhouettes. In addition, a texturing approach has been presented. The base SDK modules are laid out, explaining how QuantaCorp integrates with the eTryOn applications.
PROBLEMS AND CHALLENGES OF SCHOOL HEALTH NURSING IN AKWA IBOM AND CROSS RIVER STATES , NIGERIA

Purpose: This study evaluated the problems and chal lenges associated with school nursing in Cross River and Akwa Ibom States of Nigeria in term s of coverage, services rendered, adequacy of equipments and supplies, and involvemen t of other relevant professionals in school health programmes. Materials and methods: A descriptive design was ado pted, and sixty schools were randomly selected from the two states. In each school, one n urse was conveniently selected to give a total of sixty respondents from a population of 171 schoo l nurses from both states. Rustia’s school health promotion model guided the study. Validated questionnaire, interviews and review of records were the instruments for data collection. R esearch questions were analyzed using frequencies and percentages while the Pearson Momen t Correlation Coefficient Statistics was used to test the hypotheses determined at a signifi ca t level of 0.05. Results: Results showed low coverage of school heal th programme in Cross River (3%) and Akwa Ibom (7.2%) states. The scopes of the practice were limited to treatment of minor ailments (100%), referral services (81.7%) health e ducation (41.7%) and first aid (16.7%). Only (18.3%) of the respondents were satisfied with equipments available for school health programme. Furthermore, health services provided by the nurses were positively and significantly related to their knowledge of roles ( r=.532; df=59; p<0.05) but not on availability of material resources r=. 023; df=59; p>0.05). Recommendations: It was recommended that school nur ses should be well educated on the roles expected of them.
OP-SCAN130031 638..645

Much work in the field of social cognition shows that adopting an abstract (vs concrete) mindset alters the way people construe the world, thereby exerting substantial effects across innumerable aspects of human behavior. In order to investigate the cognitive and neural basis of these effects, we scanned participants as they performed two widely used tasks that induce an abstracting vs concretizing mindsets. Specifically, participants: (i) indicated why perform certain activities (a task that involves abstraction) or how the same activities are performed (a task that involves concretization) and (ii) generated superordinate categories for certain objects (a task that involves abstraction) or subordinate exemplars for the same objects (a task that involves concretization). We conducted a conjunction analysis of the two tasks, in order to uncover the neural activity associated with abstraction and concretization. The results showed that concretization was associated with activation in fronto-parietal regions implicated in goal-directed action; abstraction was associated with activity within posterior regions implicated in visual perception. We discuss these findings in light of construal-level theory s notion of abstraction.
CIA_A_268118 1599..1609

1Department of Orthopaedic Surgery, Third Hospital of Hebei Medical University, Shijiazhuang 050051, Hebei, People’s Republic of China; 2Key Laboratory of Biomechanics of Hebei Province, Shijiazhuang 050051, Hebei, People’s Republic of China; 3Orthopaedic Research Institution of Hebei Province, Shijiazhuang 050051, Hebei, People’s Republic of China Purpose: The in-hospital death rate in cases of hip fracture ranges from 6% to 10%. Pneumonia is a serious complication for hip fracture patients that contributes to longer hospital stays and higher mortality rates; however, the prevalence and risk factors are not well established. To address this issue, the present study investigated the incidence of and risk factors for in-hospital postoperative pneumonia (IHPOP) following geriatric intertrochanteric fracture surgery. Patients and Methods: Information on 1495 geriatric patients (>65 years) who underwent intertrochanteric fracture surgery at our hospital between October 2014 and December 2018 was extracted from a prospective hip fracture database and reviewed. Demographic information, clinical variables including surgical data, and preoperative laboratory indices that could potentially influence IHPOP were analyzed. Receiver operating characteristic curve analysis was performed and the optimum cutoff value for quantitative data was determined. Univariate and multivariate analyses were carried out to identify risk factors for IHPOP. Results: The incidence of IHPOP following geriatric intertrochanteric fracture surgery was 3.5% (53/1495 cases). The multivariate analysis showed that age >82 years (odds ratio [OR]=2.54, p=0.004), male sex (OR=2.13, p=0.017), chronic respiratory disease (OR=5.02, p<0.001), liver disease (OR=3.39, p=0.037), urinary tract infection (OR=8.46, p=0.005), creatine kinase (CK) MB>20 U/l (OR=2.31, p=0.020), B-type natriuretic peptide (BNP) ≥75 ng/l (OR=4.02, p=0.001), and D-dimer >2.26 mg/l (OR=2.69, p=0.002) were independent risks factor for the incidence of IHPOP following geriatric intertrochanteric fracture surgery. Conclusion: The incidence of IHPOP was 3.5% following geriatric intertrochanteric fracture surgery; age, male sex, chronic respiratory disease, liver disease, urinary tract infection, CKMB, BNP, and D-dimer were significant risk factors. Targeted preoperative management based on these factors could reduce the risk of IHPOP and mortality in these patients.
EFFECT OF SULPHUR AND SILICON FERTILIZATION ON GROWTH AND YIELD OF RICE

Field experiment was conducted at Experimental Farm, Annamalai university, Annamalai Nagar,Tamil Nadu, India during 2008-2009 to study the effect of sulphur and silicon fertilization on growth and yield of rice. The treatments comprised four levels of sulphur (0, 15, 30 and 45 kg ha -1 ) and four levels of silicon (0, 40, 80 and 120 kg ha -1 ) and were laid out in factorial randomized block design with three replications. Among the different levels of sulphur and silicon, sulphur @ 45kg ha -1 and 120 kg Si ha
Clinical burden of illness among patients with severe eosinophilic COPD

Background: There are currently limited real-world data on the clinical burden of illness in patients with COPD who continue to exacerbate despite receiving triple therapy. The aim of this study was to compare the burden of COPD in patients with and without a phenotype characterized by a high blood eosinophil count and high risk of exacerbations while receiving triple therapy. Methods: This retrospective cohort study (GSK ID: 207323/PRJ2647) used UK Clinical Practice Research Datalink records linked with Hospital Episode Statistics. Eligible patients had a COPD medical diagnosis code recorded between January 1, 2004 and December 31, 2014, and a blood eosinophil count recorded on/after that date. Patients were followed from index date ( ﬁ rst qualifying blood eosinophil count) until December 31, 2015. The study phenotype was de ﬁ ned as ≥ 2 moderate/ ≥ 1 severe acute exacerbation of COPD (AECOPD) in the year prior to the index date, current use of multiple-inhaler triple therapy (MITT), and blood eosinophil count ≥ 150 cells/µL on the index date. Outcomes measured during follow-up included moderate/severe AECOPDs, severe AECOPDs, all-cause mortality, primary care (GP) clinical consultations, and non-AECOPD-related unscheduled hospitalizations. Results: Of 46,814 patients eligible for inclusion, 2512 (5.4%) met the de ﬁ nition of the study phenotype. Adjusted rate ratios (95% CI) of moderate/severe AECOPDs and all-cause mortality in patients with the study phenotype versus those without were 2.32 (2.22, 2.43) and 1.26 (1.16, 1.37), respectively. For GP visits and non-AECOPD-related unscheduled hospitalizations, adjusted rate ratios (95% CI), in patients with the study phenotype versus those without, were 1.09 (1.05, 1.12) and 1.31 (1.18, 1.46), respectively. Conclusion: Patients with COPD and raised blood eosinophil counts who continue to exacerbate despite MITT represent a distinct subgroup who experience substantial clinical burden and account for high healthcare expenditure. There is a need for more effective management and therapeutic options for these patients. This study used de-identi ﬁ ed electronic medical records to describe patients with COPD and ≥ 1 recorded blood eosinophil count. We described the proportion of patients with COPD who had: (1) prescriptions for inhaled triple therapy, (2) blood eosinophil count ≥ 150 cells/µL, and (3) ≥ 2 moderate/ ≥ 1 severe exacerbation in the previous year. Patients who met these criteria were referred to as having the study phenotype. These patients had an increased rate of exacerbations, GP visits and non-COPD-related unscheduled hospitalizations, and death compared with those who did not have the study phenotype. receiving multiple-inhaler triple therapy at the index date, and who had a peripheral blood eosinophil count ≥ 150 cells/µL recorded on the index date.
Edinburgh Research Explorer ‘Just be there’

Purpose – In B2B settings, research on social media sites (SMS) has primarily examined the benefits and challenges relating to their use as well as factors driving their adoption. Recently, attention has turned to the consequences of using SMS in B2B markets. This paper extends this line of research by investigating the impact of B2B brands’ social media presence, interactivity, and responsiveness on customers’ perceptions of four indicators of brand relationship strength (commitment, intimacy, satisfaction, partner quality). Design/methodology/approach – Data from an online survey (N=200) with customers of UK-based B2B firms were analysed using structural equation modelling. Findings – The study reveals that a supplier’s presence on Twitter, LinkedIn and Facebook has a positive impact on all four brand relationship strength indicators; interactivity enhances perceived partner quality, while responsiveness positively influences commitment. Differences across the three SMS are also observed. Research limitations – The research was conducted on a sample of UK-based firms with varied degrees SMS impact brand relationship strength. Practical implications study however, B2B brands should be active in responding to customers’ queries on SMS as well as interacting with them to enhance commitment and perceived partner quality, respectively. Originality/value – This study contributes to the digital marketing and B2B relationships interface, and is the first to examine the role of B2B brands’ presence, interactivity, and responsiveness on SMS in enhancing relationships with customers.
Profiling of lysophosphatidylethanolamine molecular species in human serum and in silico prediction of the binding site on albumin

Lysophosphatidylethanolamine (LPE) is a major lysophospholipid produced by phospholipids and binds to human serum albumin (HSA). LPEs may play various roles in vivo depending on the differences in their acyl chains. However, only few reports have been published on the biological functions of LPEs. Hence, we determined the exact relative abundance of the major LPEs in the serum of healthy participants (n = 8) using liquid chromatography–tandem mass spectrometry. Consequently, LPE 18:2 (24.1 ± 5.2%) was found to be the most abundant in serum. To understand the distribution of LPEs, the serum separated via gel‐filtration high‐performance liquid chromatography was subjected to quantitative measurement. LPEs were more observed in the albumin fraction than the lipoprotein fraction. We also performed a fluorescence displacement assay and an in silico molecular docking experiment using AutoDock to confirm the affinity and binding sites of the LPEs on HSA. The binding affinities of the LPEs for drug sites 1 and 2 on HSA were relatively low, with Ki values of approximately 11 and 3.8 μM, respectively. AutoDock analysis revealed the conformation of the LPEs bound to drug sites and the possibility of LPEs binding to other HSA sites. These findings could help to elucidate the biological and pathological functions of LPEs.
Molecular Analysis With 16S rRNA PCR/Sanger Sequencing and Molecular Antibiogram Performed on DNA Extracted From Valve Improve Diagnosis and Targeted Therapy of Infective Endocarditis: A Prospective Study

Abstract Background Molecular analysis (MA) on heart valve (HV) improves the microbiologic diagnosis of infectious endocarditis (IE). The main drawback of MA is the lack of antimicrobial susceptibility information. Methods We conducted a prospective cohort observational study of consecutive adult patients from April 2012 to May 2021 who underwent valve surgery at our hospital. The performance of MA, blood cultures (BC) and valve cultures (VC), and the diagnostic and therapeutic impact of MA were evaluated. Molecular antibiogram results were compared to culture-based antimicrobial susceptibility testing (AST). Results A total of 137 patients with definite IE and 52 patients with no IE were enrolled in the study. Among IE cases BC, VC, and MA were positive in 75 (55%), 30 (22%), and 120 (88%) of IE cases, respectively. Among 62 cases of BC-negative IE (BCNE), 57 achieved diagnosis with MA. MA led to a change of antimicrobial therapy in 92% of BCNE. MA was negative in 100% of patients with no IE. Molecular antibiogram performed on 17 valve specimens that resulted positive for pathogens potential carrier of genes encoding for multidrug resistant mechanisms showed 100% concordance with AST. Conclusions MA showed a high specificity and sensitivity in etiological diagnosis of IE. Molecular antibiogram could overcome the major limitation of MA that is the lack of susceptibility testing. We advocate for the inclusion of MA among diagnostic criteria for IE and for a more extensive use of molecular antibiogram when the culture result is negative, and MA is the only positive test.
Health Literacy Profiles of Early Intervention Providers: Use of the Health Literacy Questionnaire

Background: Early intervention (EI) providers work with parents of children with or who have risk factors of developmental delay or disability through Part C of the Individuals with Disabilities Education Act. Many parents in the United States have low health literacy; therefore, EI providers should be aware of and address families' health literacy needs. EI providers need to be health literate themselves to implement evidence-based recommended practices. Objective: This study aimed to measure health literacy levels of interdisciplinary EI providers and investigate associations between health literacy levels and demographic variables. Methods: A survey containing the Health Literacy Questionnaire (HLQ) was completed by EI providers working at 10 EI centers in Massachusetts. Scale scores were calculated and compared across demographic variables, including EI job role, age, years of EI experience, and highest education level. Key Results: Of 715 EI providers invited to participate, 376 surveys were completed (52.6% response rate). Most participants were women (92.6%, n = 348), reported race as White (85.4%, n = 321), had a mean age of 43.1 years (standard deviation [SD] 12.9) ranging from 20 to 74 years, and English as their primary language (89.6%, n = 337). EI providers scored the lowest on HLQ Scale 5 “Appraisal of health information” (mean [M] = 2.99 (SD 0.50) [confidence interval (CI) 2.93, 3.04]), and Scale 7 “Navigating the healthcare system” (M = 3.83 (SD 0.58) [CI 3.77, 3.89]). EI providers having stronger health literacy profiles were generally older, with a higher education level, were licensed providers, or had more years of EI work experience. Conclusions: EI providers require adequate health literacy to manage their health needs and to effectively provide services to EI families. Study results may inform future targeted professional development to support improvement of EI providers' health literacy skills, including appraisal of health information and navigation of the health care system. [HLRP: Health Literacy Research and Practice. 2022;6(2):e128–e136. ] Plain Language Summary: EI providers' health literacy profiles have not been previously investigated. Study results reveal EI providers struggled with health literacy skills of appraising health information and navigating the health care system, which are vital for EI practice. Health Literacy Questionnaire results can inform targeted professional development to improve EI providers' health literacy levels and their clinical practice.
Sterols of Testudodinium testudo (formerly Amphidinium testudo): Production of the Δ8(14) sterol gymnodinosterol and chemotaxonomic relationship to the Kareniaceae

Testudodinium testudo is a peridinin‐containing dinoflagellate recently renamed from Amphidinium testudo. While T. testudo has been shown via phylogenetic analysis of small subunit ribosomal RNA genes to reside in a clade separate from the genus Amphidinium, it does possess morphological features similar to Amphidinium sensu stricto. Previous studies of Amphidinium carterae and Amphidinium corpulentum have found the sterols to be enriched in Δ8(14) sterols, such as 4α‐methyl‐5α‐ergosta‐8(14),24(28)‐dien‐3β‐ol (amphisterol), uncommon to most other dinoflagellate taxa and thus considered possible biomarkers for the genus Amphidinium. Here, we provide an examination of the sterols of T. testudo and show they are dominated not by amphisterol, but rather by a different Δ8(14) sterol, (24R)‐4α‐methyl‐5α‐ergosta‐8(14),22‐dien‐3β‐ol (gymnodinosterol), previously thought to be a major sterol only within the Kareniaceae genera Karenia, Karlodinium, and Takayama. Also found to be present at low levels were 4α‐methyl‐5α‐ergosta‐8,14,22‐trien‐3β‐ol, a sterol previously observed in Karenia brevis to be an intermediate in the production of gymnodinosterol, and cholesterol, a sterol common to many other dinoflagellates. The presence of gymnodinosterol in T. testudo is the first report of this sterol as the sole major sterol in a dinoflagellate outside of the Kareniaceae. The implication of this chemotaxonomic relationship to the Kareniaceae is discussed.