Miracle-dz/UniFAR-FTUs huggingface dataset:
Multidimensional Landscape of SA-AKI Revealed by Integrated Proteomics and Metabolomics Analysis

Sepsis-associated acute kidney injury (SA-AKI) is a severe and life-threatening condition with high morbidity and mortality among emergency patients, and it poses a significant risk of chronic renal failure. Clinical treatments for SA-AKI remain reactive and non-specific, lacking effective diagnostic biomarkers or treatment targets. In this study, we established an SA-AKI mouse model using lipopolysaccharide (LPS) and performed proteomics and metabolomics analyses. A variety of bioinformatic analyses, including gene set enrichment analysis (GSEA), weighted gene co-expression network analysis (WGCNA), protein and protein interactions (PPI), and MetaboAnalyst analysis, were conducted to investigate the key molecules of SA-AKI. Integrated proteomics and metabolomics analysis revealed that sepsis led to impaired renal mitochondrial function and metabolic disorders. Immune-related pathways were found to be activated in kidneys upon septic infection. The catabolic products of polyamines accumulated in septic kidneys. Overall, our integrated analysis provides a multidimensional understanding of SA-AKI and identifies potential pathways for this condition.
Serological Responses and Predictive Factors of Booster COVID-19 Vaccines in Patients with Hematologic Malignancies

Patients with hematologic malignancies are reported to have a more severe course of coronavirus disease 2019 (COVID-19) and be less responsive to vaccination. In this prospective study, we aimed to evaluate the serological responses to booster COVID-19 vaccines of Taiwanese patients with hematologic malignancies and identify potential predictive markers for effective neutralizing immunity. This study enrolled 68 patients with hematologic malignancies and 68 age- and gender-matched healthy control subjects who received three doses of vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from 1 January 2022 to 31 October 2022. The SARS-CoV-2 immunoglobulin G (IgG) spike antibody level was measured with the Abbott assay. The effective neutralization capacity was defined as an anti-spike IgG level of ≥4160 AU/mL. Among the 68 patients with hematologic malignancies, 89.7% achieved seroconversion after booster doses. Seven patients with actively treated lymphoma remained seronegative and had the lowest humoral responses among patients with different types of hematologic malignancies. Despite comparable antibody titers between patients and healthy individuals, rates of effective neutralization (66.2% vs. 86.8%, respectively; p = 0.005) were significantly reduced in patients with hematologic malignancies. In a multivariate analysis, the independent predictors for effective neutralization were a lack of B-cell-targeted agents within six months of vaccination (odds ratio, 15.2; 95% confidence interval, 2.7–84.2; p = 0.002) and higher immunoglobulin levels (odds ratio, 4.4; 95% confidence interval, 1.3–14.7; p = 0.017). In conclusion, the majority of patients with hematologic malignancies achieved seroconversion after booster vaccination. Patients with ongoing B-cell depletion and hypogammaglobinemia were identified as having negative predictive markers for effective neutralization.
Roman fortified farms (qsur) and military sites in the region of the Wadi Al-Kuf, Cyrenaica (Eastern Libya)

Fortified buildings (in Arabic known as qsur, singular qasr) that stand isolated or formed part of wider settlements are a common phenomenon that existed in many regions of Roman Africa, especially in the late Roman and late antique periods. Different interpretations of the defensive appearance of the qsur in Africa (and parallels in different parts of the Roman Empire) have been advanced. In terms of Cyrenaica, this remarkable class of sites, though the most obvious archaeological monuments of the countryside, has not received a great deal of attention in the past. Therefore, the main aim of this thesis was to make a systematic study of the typology, chronology and function of these fortified structures, drawing on archaeological and literary sources and my own fieldwork. I carried out a combination of extensive and intensive archaeological, topographical and landscape survey in the region of Wadi al-Kuf in Cyrenaica. In three different topographical blocks covering a total area of about 1,350 km 2 , a total of 55 sites was documented (42 sites were recorded for the first time by my survey). An attempt is made to distinguish between potential military and civilian sites on the basis of locational and architectural factors. A broad framework is provided by interpreting the limited dating evidence and supported by comparison with similar sites from other regions of the Roman Empire, particularly in Tripolitania. This research has made original contributions to determining the architecture, typology and chronology of qsur in the survey region and overall it has increased our knowledge of rural settlement in the Wadi al-Kuf region.
Benevolent Transgressive Play in Dungeons & Dragons [D&D]

Background Research into transgressive play experiences in games has grown in recent years. In this article, we explore the potential for transgressive play to be constructive in multiplayer settings—something we conceptualize as “benevolent transgression. ” Aim This article describes the presence and appeal of benevolent transgressive play experiences in the tabletop role-playing game Dungeons & Dragons [D&D]. Research Methods In 2021, amid the COVID-19 pandemic, we conducted focus group discussions (3 groups, 14 participants, aged 24–55) and an online survey (354 participants, aged 18–63) with current D&D players to better understand what play experiences were meaningful and appealing for them—in consideration of the game’s contemporary resurgence. Key Finding and Discussion Our qualitative analysis focuses on participant responses that described the presence and appeal of transgressive play that knowingly challenges player boundaries or game boundaries, what we term benevolent transgression. We propose two key factors that we believe enable it—1) player agency and 2) collaborative negotiation—and briefly discuss benevolent transgression in consideration of game-based learning [GBL].
The Relationship Between Family Involvement and Satisfaction Level of The Family of Critical Care Patients in The Sumber Waras Hospital

The average trend of intensive care unit (ICU) patients increases every day across the globe, including in Indonesia. Patients and their families have various needs during intensive care in the ICU. Based on these needs, we classify them into care, hope, information, participation, and assurance. In order to fulfill these needs, support and involvement of family members are needed. If the needs are fulfilled, this will have an effect on the satisfaction of family members. Therefore, this study aims to investigate the relationship between family involvement and family satisfaction of critical patients in Intensive Care Unit of Sumber Waras Hospital, West Jakarta. Descriptive and analytic research design with a quantitative approach is used in this study. Samples were collected using a consecutive sampling method and a questionnaire was used as a data collection instrument. Pearson Chi-Square correlation test was performed to determine the relationship among variables. This study showed the average scores of family involvement and family satisfaction were 4.0-4.3 out of 5 on a Likert scale. From 49 respondents, 29 respondents had a higher level of involvement in information and 34 respondents had a higher level of satisfaction in assurance. Family involvement in care, hope, information, participation, and assurance had a significant positive association with family satisfaction, with the effect exerted at 42%, 56%, 51%, 49%, and 49%, respectively. From this study, we can conclude that the patient’s family members had a moderately to very high level of involvement and satisfaction. There is a significant positive association between family involvement and family satisfaction in the Sumber Waras Hospital, West Jakarta.
Volcanic Eruptions: A Source of Irreducible Uncertainty for Future Climates

Volcanic forcing, a major natural source of climate variability, represents a challenge for current climate modeling because of the unpredictability and specificity of individual eruptions, and because of the complexity of processes linking the eruption to the climate response. Volcanic forcing is largely underrepresented in available future climate projections, which is a critical problem. The study by Man Mei Chim and Colleagues (Chim et al., 2023, https://doi.org/10.1029/2023GL103743) tackles this known unknown and reveals how climatically relevant volcanic activity may be stronger than currently thought in a future warmer climate, enhancing uncertainty of climate projections. The study exemplifies the profound implications of inaccuracies within simplified climate scenarios and motivates new research on volcanically forced climate variability. It also arouses some thoughts on climate uncertainty communication.
Application effect of a Donabedian three-dimensional quality evaluation model in perioperative nursing of early gastric cancer male patients undergoing endoscopic mucosal dissection

The effect of Donabedian three-dimensional quality evaluation model is explored for the high-quality nursing during perioperative period of endoscopic mucosal dissection in early gastric cancer male patients. Seventy-eight early gastric cancer male patients were randomly grouped as 39 cases in control having received routine care, while 39 in the intervention group having received routine care combined with the three-dimensional quality evaluation model. Clinical recovery indicators including anxiety, depression, pain, life quality and complications were compared for the two groups. The intervention group’s clinical nursing recovery indicator scored higher than that of the control. The scores of each the short-form 36 item health survey questionnaire (SF-36) dimension were better than those of control, and the differences were statistically significant (p < 0.05). The incidence of complications in intervention group was 5.12%, and that in the control was 20.5%. The intervention group experienced less complications than the control, and the difference was statistically significant (p < 0.05). Treating early gastric cancer male patients with endoscopic mucosal dissection using three-dimensional quality evaluation model can improve clinical recovery and life quality, and reduce anxiety, depression, pain and complications.
Diet Outcomes from a Randomized Controlled Trial Assessing a Parenting Intervention Simultaneously Targeting Healthy Eating and Substance Use Prevention among Hispanic Middle-School Adolescents

Parents play a significant role in adolescent health behaviors; however, few nutrition interventions for Hispanic adolescents involve parents. This study assessed the effects of a 10-week parenting intervention simultaneously targeting nutrition and substance use prevention. Hispanic parent/6th–8th-grade adolescent dyads (n = 239) were randomized to Families Preparing the New Generation Plus (FPNG+; nutrition/substance use prevention), FPNG (substance use prevention only), or Realizing the American Dream (RAD; academic success control). Surveys assessed diet, alcohol use, substance use intentions, and substance use norms at baseline (T1), immediately post-intervention (T2), and at 16 weeks post-intervention (T3). Latent change modeling assessed diet changes; adolescent substance use outcomes were assessed using effect sizes. Among adolescents, those in FPNG+ increased fruit (+0.32 cup equivalents, p = 0.022) and fiber intake (+1.06 g, p = 0.048) and did not change added sugars intake at T2; those in FPNG and RAD reduced their intake of fruit and fiber (p < 0.05 for both). FPNG+ parents marginally increased fruit/vegetable intake (+0.17 cup equivalents, p = 0.054) and increased whole grains intake (+0.25-ounce equivalents, p < 0.05), in contrast to the reduction among RAD and FPNG parents (p < 0.05). Reductions in added sugar intake at T2 were greater among FPNG and FPNG+ parents relative to RAD parents (p < 0.05). FPNG+ and FPNG had comparable substance use outcomes (i.e., both had lower alcohol use and intentions to use substances relative to RAD). Engaging parents in a nutrition and substance use prevention parenting intervention yielded positive changes in dietary intake and maintained substance use prevention outcomes among their adolescent children.
Planning Approval Process: An Analysis of Property Developers’ Experiences in Southwestern Nigeria

Globally, development control is one of the main activities of the planning agencies aimed at ensuring sustainable development in human settlements. Previous studies primarily explored compliance with planning regulations whereas issues of awareness, satisfaction, and willingness to participate have not been adequately dealt with. This study evaluates the property developers’ experiences with the planning approval process (PAP) in southwestern Nigeria. The specific objectives are to (i) probe property developers’ awareness of the legality of the PAP, (ii) examine property developers’ satisfaction levels regarding the PAP, (iii) determine property developers’ willingness to participate in PAP discourse, and (iv) examine problems associated with the PAP. Purposive and convenience sampling techniques were adopted to elicit data from 96 respondents using a structured questionnaire. Data were analyzed using both descriptive and inferential statistics. Major findings showed that 68.8% of the developers were aware of the legality of PAP, 70.8% expressed satisfaction with the PAP, and 78.1% were willing to participate in public discourse about PAP. Fishers’ Exact test revealed that the location of developers (χ2= 6.907, p=0.025) and gender (χ2= 0.000, p=0.023) were significantly associated with developers’ awareness of the legality of PAP. The Spearman Correlation test indicated a significant association between developers’ satisfaction with PAP and their support for seeking planning approval (r=0.339, p=0.001) as well as planning approval processing time (r=0.250, p=0.026). The study recommends aspects of PAP the planning agencies need to improve upon towards achieving sustainable PAP. The study outcome will be useful for policy formulation in areas of education and awareness creation, planning approval processing time, and procuring documents required by the planning agencies. Addressing these issues will mean property developers will derive greater satisfaction from planning agencies’ services and will be inspired to participate in planning matters.
CALIDAD FISICOQUÍMICA Y MICROBIOLÓGICA DE LECHES CRUDAS EN EMPRESAS GANADERAS DEL SISTEMA DOBLE PROPÓSITO EN MONTERÍA (CÓRDOBA)

Mastitis is the inflammation of the mammary glands in response to neutralize infectious agents and return to normal function. This inflammatory response decreases the synthesis of different components, which reduce the milk quality. The purpose of this study was to determine physicochemical and microbiological quality of tank milk and the udder health in 15 dual-purpose system enterprises in Monteria (Cordoba), chosen by non-probability sampling and a cross-sectional study. A tank milk sample in each of the enterprises involved in the study was collected. The density, acidity percentage, protein, lactose, mesophilic and somatic cell count was determined. Also, the prevalence of mastitis and, by extrapolation, economic losses were calculated. Statistical analysis was executed using SAS software. Physicochemical values were within normal values. Mesophilic count was 160.347 ± 213.354 Cfu/mL and somatic cell count of 345.133 ± 302.241 SC/mL. In all enterprises the prevalence of mastitis varied from 13.8% to 74.7%. Linear regression was found between the prevalence of mastitis and somatic cell count (R2=0,867). In seven of these enterprises, somatic cell count was up to 250.000 SC/mL, which warrants the immediate implementation of prevention and control of bovine mastitis.
Nitrate Trends in Minnesota Rivers

Regular sampling of river and stream water for nitrate began at numerous sites on Minnesota’s rivers during the mid-1970s, and many of these sites continued to be monitored through 2008-2011. A few of these sites were previously assessed for nitrogen (N) load and concentration temporal trends, as is reported in Chapter C2. However, most sites have either not been assessed for nitrate trends or have been studied for trends using a shorter period of time and different statistical methods compared to this study.
The unhomed data subject: negotiating datafication in Latin America

ABSTRACT Critical scholarship about datafication reveals the implications of algorithmically driven digital transformations for both social processes and human experiences of subjectivity. Digital transformations embed ontological beliefs in the information systems that drive new organizational processes and are accompanied by techno-positivist discourses that promote the benefits of these schemes. The dual power of new information systems plus strong discursive influences has led to fears that data subjects will come to be defined by data and information systems – that their subjectivity will be subordinated by the algorithm. However, in this paper, we argue that real experiences of data sharing offer a means to reveal actual experiences with subjectification, and that often these experiences are multiple and complex. Drawing on the results of five digital literacy interventions carried out by partner organizations in Chile, Colombia, Paraguay, Peru, and Uruguay in 2021, we consider participants’ lived experiences with datafication. Our work reveals how people experience, negotiate, reject, and accept data power’s multiple manifestations in ways that strategically mobilize data resources, constituting a fractured data subjectivity that overlaps the bounds of any one information system. This leads us to suggest the idea of the ‘unhomed’ as a useful concept for understanding data subjectification in the contemporary moment.
Plant Diseases Classification based Leaves Image using Convolutional Neural Network

Plant disease is one of the problems in the world of agriculture. Early identification of plant diseases can reduce the risk of loss, so automation is needed to speed up identification. This study proposes a custom-designed convolutional neural network (CNN) model for plant disease recognition. The proposed CNN model is not complex and lightweight, so it can be implemented in model applications. The proposed CNN model consists of 12 CNN layers, which consist of eight layers for feature extraction and four layers as classifiers. Based on the experimental results of a plant disease dataset consisting of 38 classes with a total of 87,867 image records. The proposed model can get high performance and not overfitting, with 97%, 98%, 97% and 97%, respectively, for accuracy, precision, recall and f1-score. The performance of the proposed model is also better than some popular pre-trained models, such as InceptionV3 and MobileNetV2. The proposed model can also work well when implemented in mobile applications.
Agro-Based Spent Mushroom Compost Substrates Improve Soil Properties and Microbial Diversity in Greenhouse Tomatoes

Spent mushroom compost (SMC) substrates are commonly used as growth media for greenhouse crops and horticulture production. This study aimed to investigate the responses of physiochemical soil properties, enzyme activities, and microbial community compositions to different cultivation durations and SMC soil treatments on tomatoes. The experiment included the following treatments: SMC substrate and the surrounding soil after planting at 1, 3, and 7 years and comparing control treatments including non-planting SMC substrates and continuous mono-cropping soil. The results revealed that the SMC substrates had higher contents of total N P and organic C nutrients than the surrounding soil treatments. The physicochemical soil properties and soil enzyme activities of the SMC substrates were significantly decreased with longer cultivation duration. Microbial alpha diversity was higher in the SMC substrates regardless of cultivation duration than in the control treatments. It was observed that many beneficial microbes, such as bacteria of the Deinococcus-Thermus, Halanaerobiaeota, and Nitrospirae phyla, and the fungi of the Basidiomycota, Mortierellomycota, and Chytridiomycota phyla were enriched in the SMC substrates. The SMC substrate and surrounding soil had enriched several potentially beneficial microorganism genera such as the bacterial Saccharimonadales, Gaiella, Bacillus, and the fungal Thermomyces, Kernia, and Mortierella. Therefore, the agro-based SMC substrate grooved cultivation system is recommended as an environmentally compatible practice for tomato growth in the greenhouse.
Facebook-based social media marketing and Facebook-based online purchases: evidence from the Facebook page admins of selected South Asian fashion retailers

PurposeThis study intends to explore the connection between Facebook-based social media marketing (FSMM) and Facebook-based online purchase order (FOPO) for 20 popular online fashion retail brands across three South Asian countries: India, Pakistan and Bangladesh. FSMM was further divided into four components: Perceived trust (PT), Perceived informativeness (PInf), Perceived interactivity (PInt) and Perceived benefit (PB). Design/methodology/approachThe authors selected 20 popular Facebook-based online fashion brands involved in clothing and fashion accessories businesses in those three countries. Later, the authors purposively selected 114 region-based Facebook page administrators (admins) responsible for operating those brands' Facebook pages and taking Facebook-based online orders. The authors collected primary data from those admins as respondents through a structured survey instrument. The authors applied SPSS 25 for descriptive analysis and a covariance-based structural equation modeling (CB-SEM) (through AMOS 25) for testing the hypothesized relations.FindingsBased on the valid responses and application of proper statistical measures, it was revealed that three FSMM components: PT, PInf and PB have significant positive relationships with FOPO, while PInt has an insignificant relationship with FOPO. Originality/valueSouth Asia is a growing business hub and the largest consumer market in terms of population. This study was conducted to identify the relationship between FSMM and FOPO in the three most prominent South Asian countries. As the first study was undertaken ever on customer perceptions of FSMM in a multi-country South Asian context, this paper is expected to be helpful for academics in conducting further empirical investigations on Facebook-based marketing as well as practitioners and policymakers in formulating and implementing Facebook-based marketing strategies.