Miracle-dz/UniFAR-FTUs huggingface dataset:
The acceptance of mobile teledermoscopy by primary care nurse practitioners in the state of Arizona

PURPOSE To conduct a pilot survey to assess acceptance of mobile teledermoscopy (MTD) by primary care nurse practitioners (NPs) working in Arizona. DATA SOURCES Sixty-two participants recruited from NP and academic listservs in Arizona completed an online survey prefaced by a MTD definition, device photographs, and a practice case, followed by 33 items measuring Teledermatology Technology Acceptance Model (TeleTAM) constructs. CONCLUSIONS Participants were highly interested in using MTD to assess skin lesions. They perceived MTD utility to greatly improve diagnosis and positively impact their practice. Most participants had never used MTD, but had high mean scores for MTD attitude and moderate scores for MTD perceived ease of use, perceived use, and facilitators of MTD. They had moderate scores for intention to use MTD. The construct facilitators (organizational infrastructure) were most strongly associated with intention to use MTD. Cronbach alphas were 0.70 or higher for all subscales except compatibility and habit. IMPLICATIONS FOR PRACTICE Moderate acceptance of MTD may reflect NPs' knowledge of the technology, self-confidence for using it, or MTD financial constraints. Future research will address these factors to foster use of MTD by NPs, thereby improving patients' access to early skin lesion assessment and diagnosis.
Immunog lobu l in E and T Lymphocyte Reactivity o f Isoforms o f the Major Birch Pollen Allergen Bet v 1 : Potential Use o f Hypoallergenic Isoforms for Immunotherapy

W e dissected the T cell activation potency and the immunoglobul in (Ig) E-binding properties (allergenicity) o f nine isoforms of Bet v 1 (Bet v 1a-Bet v 11), the major birch pollen allergen. Immunoblo t experiments showed that Bet v 1 isoforms differ in their ability to bind IgE from birch pollen-allergic patients. All patients tested displayed similar IgE-binding patterns toward each particular isoform. Based on these experiments, we grouped Bet v 1 isoforms in three classes: molecules with high IgE-binding activity (isoforms a, e, and j), intermediate IgE-binding (isoforms b, c, and 0, and low/no IgE-binding activity (isoforms d, g, and 1). Bet v la, a recombinant isoform selected from a c D N A expression library using IgE immunoscreening, exhibited the highest IgE-binding activity. Isoforms a, b, d, e, and 1 were chosen as representatives from the three classes for experimentation. The potency of each isoallergen to activate T lymphocytes from birch pollen-allergic patients was assayed using peripheral blood mononuclear cells, allergen-specific T cell lines, and pept ide-mapped allergen-specific T cell clones. Among the patients, some displayed a broad range o f T cell-recognition patterns for Bet v 1 isoforms whereas others seemed to be restricted to particular isoforms. In spite o f this variability, the highest scores for T cell proliferative responses were observed with isoform d (low IgE binder), followed by b, 1, e, and a. In vivo (skin prick) tests showed that the potency of isoforms d and 1 to induce typical urticarial type I reactions in Bet v 1-allergic individuals was significantly lower than for isoforms a, b, and e. Taken together, our results indicate that hypoallergenic Bet v 1 isoforms are potent activators of allergen-specific T lymphocytes, and Bet v 1 isoforms with high in vitro IgE-binding activity and in vivo allergenicity can display low T cell antigenicity. Based on these findings, we propose a novel approach for immunotherapy of type I allergies: a treatment with high doses of hypoallergenic isoforms or recombinant variants ofa topic allergens. We proceed on the assumption that this measure would modulate the quality o f the T helper cell response to allergens in vivo. The therapy form would additionally implicate a reduced risk ofanaphylactic side effects.
LSU Digital Commons LSU Digital Commons Within Season Hematological Changes in College Athletes with Within Season Hematological Changes in College Athletes with Sickle Cell Trait Sickle Cell Trait

PURPOSE : To explore the hematological differences in African-American athletes with sickle cell trait (SCT) and healthy controls (CON) before preseason camp and the changes that occur after a full season. METHODS : Sixteen (n=8 SCT; n=8 position matched, CON) NCAA Division 1 athletes (12 football, 2 each women’s soccer and volleyball) had blood drawn before preseason camp, after and at the end of the season, and analyzed for Hb electrophoresis (Hb-A, Hb-A2, Hb-S, and Hb-F), complete blood count with differential, chemistry panel 26, and prothrombin time, activity and international normalized ratio (INR). RESULTS : Baseline total Hb was similar between SCT and CON (mean±SD; 14.2±1.3 vs. 14.1±0.9g/dL, resp; P=0.87), and as expected, Hb-A was lower and Hb-A2 and Hb-S were higher in SCT than CON (P<0.001 for all). Baseline neutrophils were higher (4.43±1.29 vs. 3.28±0.93cellsx10 ^3 /mL, P<0.005) and lymphocytes tended to be lower (1.56±0.45 vs. 1.99±0.39cellsx10 ^3 /mL; P=0.09) amongst SCT compared to CON, respectively. Baseline amylase (99.4±25.4 vs. 72.9±18.8u/L; P=0.03), uric acid (6.8±1.7 vs. 5.5±0.8mg/dL; P=0.08), and creatinine (1.2±0.2 vs. 1.0±0.2mg/dL; P=0.07) were higher in SCT compared to CON. All Hb measures in SCT were similar after camp compared to baseline (P>0.33 for all). Baseline and position adjusted change in neutrophils were similar between SCT and CON (mean, 95%CI; -0.09, -2.06 to similar across all measures (P>0.07 for all) when comparing preseason to postseason. The adjusted change in sodium (-0.44, -1.22 to 0.35 vs. 1.13, 0.38 to 1.87; P<0.006) and GGT (0.95, -2.73 to 4.62 vs. 5.32, 1.77 to 8.88; P<0.02) showed significant difference between SCT and CON, after season compared to baseline. CONCLUSION : Despite major hematological differences due to SCT, very few changes occurred during the exhaustive, preseason camp and regular season at sea level.
Prevalence of Intestinal Helminths Infestation and Associated Risk Factors among Pupils in Basic Schools at Aboshareef Area, Kosti Locality, White Nile State, Sudan, 2019

Intestinal helminths infections are major parasitic diseases causing public health problems in Sudan, especially among children. A cross-sectional school-based study was conducted among pupils to estimate the prevalence of intestinal helminths and associated factors. We enrolled a total of 337 pupils selected in this study. Data were collected using a structured pre-tested questionnaire. Fresh stool samples collected and examined using duplicate Kato-Katz techniques. The presence of eggs considers a positive result. The sample size was distributed proportionally over the schools according to the weight and sampling unit was selected using simple random sampling. Data were collected through trained data collectors and analyzed using SPSS version 25. The prevalence of intestinal helminths among primary school pupils was 39.2%. The types of helminths detected in this study are hookworm with a prevalence of 24%, followed by 11%, Trichuris trichiura 4.2%, Hymenolepis nana 3.3%, Taenia species 3.6% and Entrobius vermicularis 5.9%. A high association was observed between infection with helminths and sex (p <0.001), source of drinking water (p < 0.05), the type of toilet at school (p <0.001), absence of sanitary facilities near or inside latrine in houses (p > 0.05) and educational level of the mother (p <0.001). Therefore, Studying the prevalence of intestinal helminths among primary school pupils with the associated risk factors in developing countries may predict health status. Therefore, help in better diagnosis, the efficacy of medicine and improve public health.
Ca 2 (cid:1) -Independent, Inhibitory Effects of Cyclic Adenosine 5 (cid:2) -Monophosphate on Ca 2 (cid:1) Regulation of Phosphoinositide 3-Kinase C2 (cid:1) , Rho, and Myosin Phosphatase in Vascular Smooth Muscle

We have recently demonstrated in vascular smooth muscle (VSM) that membrane depolarization by high KCl induces Ca 2 (cid:1) -dependent Rho activation and myosin phosphatase (MLCP) inhibition (Ca 2 (cid:1) -induced Ca 2 (cid:1) -sensitization) through the mechanisms involving phosphorylation of myosin-targeting protein 1 (MYPT1) and 17-kDa protein kinase C (PKC)-poten-tiated inhibitory protein of PP1 (CPI-17). In the present study, we investigated whether and how cAMP affected Ca 2 (cid:1) -depen-dent MLCP inhibition by examining the effects of forskolin, cell-permeable dibutyryl cAMP (dbcAMP), and isoproterenol. Forskolin, but not its inactive analog 1,9-dideoxyforskolin, in- hibited KCl-induced contraction and the 20-kDa myosin light chain (MLC) phosphorylation without inhibiting Ca 2 (cid:1) mobilization in rabbit aortic VSM. dbcAMP mimicked these forskolin effects. We recently suggested that Ca 2 (cid:1) -mediated Rho activation is dependent on class II (cid:1) -isoform of phosphoinositide 3-kinase (PI3K-C2 (cid:1) ). Forskolin inhibited KCl-induced stimulation of PI3K-C2 (cid:1) activity. KCl-induced membrane depolarization stimulated Rho in a manner dependent on a PI3K but not PKC and stimulated phosphorylation of MYPT1 at Thr 850 and CPI-17 at Thr 38 in manners dependent on both PI3K and Rho-kinase, but not PKC. Forskolin, dbcAMP, and isoproterenol inhibited KCl-induced Rho activation and phosphorylation of MYPT1 and CPI-17. Consistent with these data, forskolin, iso- proterenol, a PI3K inhibitor, or a Rho kinase inhibitor, but not a PKC inhibitor, abolished KCl-induced diphosphorylation of MLC. These observations indicate that cAMP inhibits Ca 2 (cid:1) mediated activation of the MLCP-regulating signaling pathway comprising PI3K-C2 (cid:1) , Rho, and Rho kinase in a manner independent of Ca 2 (cid:1) and point to the novel mechanism of the cAMP actions in the regulation of vascular smooth muscle contraction.
WIP: What Makes Courses Demanding in Engineering Education? A Combination of Mixed Methods and Grounded Theory Research

Isabel Hilliger is the Associate Director for Assessment and Evaluation at the Engineering Education Division in Pontificia Universidad Católica de Chile (UC). Isabel received a BEng from UC and an MA in Education Policy from Stanford University. She is currently a PhD Candidate in Computer Science at UC-Engineering. Her research theme is the use of methodologies and analytical tools for continuous curriculum improvement in Higher Education. She has created qualitative and quantitative instruments for outcome assessment in enginering education. She has also evaluated policy efforts towards engineering diversity and undergraduate research.
Optimisation and Development of Prunus var dulcis Gum Capsule Film

Prunus amaygdalus var dulcis gum commonly known as almond gum is a polymer. Capsules made up of almond gum was used as a stand-in to gelatin capsule and the fusion of Aegle marmelos was found to help prevent peptic ulcer. Anti-bacterial property of almond gum helps increasing the shelf life of capsules. To standardize and formulate Aegle marmelos incorporated Prunus amaygdalus var dulcis gum capsule and to assess the microbial and solubility properties of Aegle marmelos incorporated Prunus amaygdalus var dulcis gum capsule. The samples were formulated and standardized using five grams of almond gum and one gram of Aegle marmelos . Glycerol and sorbitol were used as plasticizers. Hydroxy Propyl Methyl Cellulose and carrageenan gum were used as a binding agent for the formulation of Aegle marmelos incorporated almond gum capsule and it entails antioxidant, anti-ulcerative and anti-bacterial property. Predominantly, the anti-ulcerative property was due to the tannin content. The microbial content and solubility properties were also determined and compared with gelatin capsules. The swelling property and moisture content of the sample decreased as the concentration increased. The total bacterial count of Aegle marmelos incorporated almond gum capsule of AMV1 was 5.0± 0.042 CFU/g and for AMV2 was 7.0±0.023 CFU/g when compared with standard (98.0 ± 0.05 CFU/g) and is significant at 5% level. The water solubility content of standard was 25% and for AMV1 and AMV2 was 80% and 97% respectively and found to be significant at 5% level. The swelling index of AMV1 was higher at 40 % when compared to standard (20%) and AMV2 (30%) and is due to presence of high volume of water using method I. Using method II, the swelling index of AMV1 was higher at 9.3 compared to other two samples of standard (-6.3) and AMV2 (-3.8) and is because of the medium density of the material. The moisture content of AMV1 was higher at 23% as determined by two methods when compared with standard and AMV2. The tannin content in Aegle marmelos helps to prevent peptic ulcer in individuals and almond gum, a natural polymer is a best vegetarian capsule alternative to gelatin. capsule. The present study proved that anti-bacterial and solubility properties of Aegle marmelos incorporated almond gum and is far better in health perspective as compared to normal commercial capsule.
Myocardial revascularization : factors intervening in the reference and counter-reference in Primary Health Care *

www.ee. usp.br/reeusp Rev Esc Enferm USP · 2016;50(6):963-970 * Extracted from the research project “Paciente Cardíaco Revascularizado: processo de referência e contrarreferência dos Serviços de Saúde de Santa Catarina”, Universidade Federal de Santa Catarina, 2013-2014. 1 Universidade Federal de Santa Catarina. Florianópolis, SC, Brazil. ABSTRACT Objective: Understanding the factors that influence the reference and counter-reference process of people indicated/submitted to Myocardial Revascularization surgery in the Primary Health Care scenario. Method: A qualitative research anchored in the Grounded Theory, totaling 41 participants subdivided into three groups (patients, health professionals and managers) in the Metropolitan and West Region of Santa Catarina. Results: Two categories elucidate the intervening factors found, contrasting the potentialities and obstacles in (creating) the bond between people affected by cardiovascular diseases and primary health care for the reference process, highlighting weaknesses in the primary health care services provided, with failures in the counter-reference for people submitted to myocardial revascularization surgery. Conclusion: Strengthening the potentialities presented in this study is essential for the reference process of people affected by Cardiovascular Disease, as well as strategic actions focused on solving the evidenced obstacles which contribute to deficiencies in the referral and counter-referral process, thus impeding integral care in the health care network.
VIRTUAL REALITY EXPLORATION WITH DIFFERENT HEAD-RELATED TRANSFER FUNCTIONS

One of the main challenges of spatial audio rendering in headphones is the crucial work behind the personalization of the so-called head-related transfer functions (HRTFs). HRTFs capture the listener’s acoustic effects allowing a personal perception of immersion in virtual reality context. This paper aims to investigate the possible beneﬁts of personalized HRTFs that were individually selected based on anthropometric data (pinnae shapes). Personalized audio rendering was compared to a generic HRTF and a stereo sound condition. Two studies were performed; the ﬁrst study consisted of a screening test aiming to evaluate the participants’ localization performance with HRTFs for a non-visible spatialized audio source. The second experiment allowed the participants to freely explore a VR scene with ﬁve audiovisual sources for two minutes each, with both HRTF and stereo conditions. A questionnaire with items for spatial audio quality, presence and attention was used for the evaluation. Results indicate that audio rendering methods made no difference on responses to the questionnaire in the two minutes of a free exploration.
A Mediterranean Diet-Based Lifestyle Intervention in Inflammatory Bowel Disease Patients with Quiescent Disease; A Pilot Study

Aim: Evidence is emerging that a Mediterranean diet (MeD) can modulate the immune system and restore the gut epithelial barrier, thereby ameliorating inflammatory bowel disease (IBD)-related symptoms and quality of life (QoL) in IBD patients. We investigated the effects of a MeD-based lifestyle intervention on tolerance, IBD-related symptoms, QoL and inflammation in IBD patients with quiescent disease. Methods: 39 patients with quiescent IBD were included to follow the MeD-based lifestyle intervention of Voeding Leeft, consisting of three full-day live group sessions and professional guidance during three months. Patients filled in validated questionnaires to evaluate their current diet (Mediterranean Diet Serving Score (MDSS)) and to determine their food-related QoL (FRQoL), disease-related QoL (short IBD questionnaire (sIBDQ)), the severity of fatigue and IBD-related disability (IBD disability index (IBD-DI)). Body Mass Index (BMI) was calculated and the hand grip strength (HGS) was measured, like C-reactive protein (CRP) in the blood and Calprotectin (FCP) in the feces. Results: In quiescent IBD patients, 69% was able to adhere to the MeD-based lifestyle intervention. The improvement in MDSS was correlated to the increase in QoL, but this effect was only observed in patients with Crohn’s disease (CD), not with ulcerative colitis (UC). CRP and BMI decreased during the study period. Conclusion: months patients reported less fatigue, patients had an improved quality of life and a lower BMI with an improved handgrip strength. This study underlines the importance of nutrition in the management of IBD.
Intrathecal Nicardipine for Cerebral Vasospasm Post Subarachnoid Hemorrhage–a Retrospective Propensity-Based Analysis

Objectives : Cerebral vasospasm and delayed cerebral ischemia (DCI) contribute to poor outcome following subarachnoid hemorrhage (SAH). With the paucity of effective treatments, we describe our experience with intrathecal (IT) nicardipine for this indication. Methods : Patients admitted to Emory University Hospital Neuroscience ICU between 2012-2017 with non-traumatic SAH, either aneurysmal or idiopathic, were included in the analysis. This patient cohort was compared using a propensity-score model to patients in the SAH international trialist (SAHIT) repository who did not receive intrathecal nicardipine. The primary outcome was DCI. Secondary outcomes were long-term functional outcome and adverse events. Results : The analysis included 1,351 patients, 422 of whom were diagnosed with cerebral vasospasm and treated with IT nicardipine. When compared with patients with no vasospasm (n=859) the treated group was younger (51.1±12.4 vs. 56.7±14.1, p<0.01), had a higher World Federation of Neurological Surgeons score (WFNS), modified Fisher grade, and more likely to undergo clipping of the ruptured aneurysm as compared to endovascular treatment (30.3% vs. 11.3%, p<0.01). Treatment with IT nicardipine decreased daily mean transcranial Doppler velocities in 77.3% of the treated patients. When compared to patients not receiving IT nicardipine, treatment was not associated with an increase rate of bacterial ventriculitis (3.1% compared with 2.7%, p>0.1) yet higher rates of ventriculoperitoneal shunting were noted (19.9% vs. 8.8%, p<0.01). In a propensity score comparison to the SAHIT database, the odds ratio to develop DCI with IT nicardipine treatment was 0.61 with 95% CI[0.44-0.84], and to have a favorable functional outcome (mRS ≤ 2) was 2.17[1.61-2.91]. The was also associated with increased rate of VPS. The results
Long-term E cacy of GPi DBS for Cranio Facial Dystonia: a Retrospective Report of 13 Cases

Haibo Ren Sichuan University and Nanchong Central Hospital Rong Wen The Second A liated Hospital of Chongqing Medical University Wei Wang (  wcnsww@163.com ) Sichuan University West China Hospital https://orcid.org/0000-0002-3110-5767 Denghui Li West China Hospital, Sichuan University Mengqi Wang West China Hospital, Sichuan University Yuan Gao West China Hospital, Sichuan University Yang Xu West China Hospital, Sichuan University Yang Wu West China Hospital, Sichuan University
Monitoring results after 12 months of provision of heating and cooling at the 8 demonstration buildings of the European project “Ground-Med”

A new generation of high efficiency ground source heat pump systems was developed by the GROUND MED project (1.01.2009 – 31.12.2014). These GSHP systems have been installed and demonstrated in 8 buildings of South Europe. The project was supported by the FP7 program of the European Commission. After two complete seasons of monitoring heating and cooling operation, the project proved that the technological advantage of high efficiency heat pumps can be utilized in its full potential by borehole heat exchangers delivering water at favourable temperature levels (7-20°C in heating and 14-39°C in cooling), low temperature indoor heating system (supplying water of 28-43°C for heating and 7-18°C for cooling) and advanced operation controls synchronizing pumps, fans and compressors while optimizing water supply temperature to the building. Superior seasonal performance factors SPF2 (considering electricity consumption at the compressors and external pump) were achieved, namely 3.63-5.91 in heating, 4.87-6.76 in active cooling and 9.80-16.59 in free cooling modes, well above project objectives and the EU average SPF of ground source heat pumps.
Productive Capabilities: A Framework for Vocational Education

This paper develops the capabilities approach for application to vocational education by intro-ducing the notion of productive capabilities, which we define as what individuals can be and do in work which they have reason to value. The paper outlines productive capabilities and derives seven implications for vocational education: promote agency, develop reason, contribute to common capacity, become institutionalised, have strong organisations, and prepare graduates for occupational and educational advancement. The paper tests two implications of productive capabilities for vocational education in three countries: Côte d’Ivoire, England, and Taiwan. The paper concludes by examining the limitations of the work so far and how these may be addressed in future work.
Women on the board and their joint effect on accruals-based earnings management and real earnings management

Much emphasis has been placed on the composition of women on the board lately. With Norway in the forefront, other countries within Europe have followed their path and implemented gender quotas on the board, and EU member countries are suggested to have 40 percent women on their boards by 2020. This study determines the effect gender-diverse boards has on accruals-based and real earnings management by comparing Norway and Sweden. The study also determines the effect independent women board members have on earnings management. Our samples consist of Norwegian and Swedish publicly listed companies, and the total number of observations amounts to 2165 from 2011 to 2018. After conducting several OLS-regressions we are able to conclude that both women board members and independent women board members have a decreasing effect on primarily accruals-based earnings management in Sweden, and only weak results are found for real earnings management in Sweden. Though, no conclusions can be drawn for the gender quota pioneer Norway, due to insignificant results.