Miracle-dz/UniFAR-FTUs huggingface dataset:
The Urinary Glucose Excretion by Sodium–Glucose Cotransporter 2 Inhibitor in Patients With Different Levels of Renal Function: A Systematic Review and Meta-Analysis

Objective Previous evidence suggested that sodium–glucose cotransporter 2 inhibitor (SGLT2i)-mediated urinary glucose excretion (UGE) appeared to be reduced with a decrease in glomerular filtration rate. Thus, we conducted a systematic review and meta‐analysis to compare SGLT2i-mediated UGE among individuals with different levels of renal function. Methods We conducted systematic searches in PubMed, Medline, Embase, Cochrane Central Register of Controlled Trials, and ClinicalTrial.gov from inception to May 2021. Clinical studies of SGLT2i with reports of UGE changes in predefined different levels of renal function were included. The results were expressed as pooled effect sizes with 95% confidence interval (CI). A random-effects model was used to calculate the pooled effect sizes. Results In total, eight eligible studies were included. Significant differences were observed in the post-treatment UGE level among subgroups stratified by renal function (P <0.001 for subgroup difference), which were gradually decreased along with the severity of impaired renal function. Consistently, changes in UGE before and after SGLT2i treatment were also decreased along with the severity of impaired renal function [67.52 g/day (95%CI: 55.58 to 79.47 g/day) for individuals with normal renal function, 52.41 g/day (95%CI: 38.83 to 65.99 g/day) for individuals with mild renal function impairment, 35.11 g/day (95%CI: 19.79 to 50.43 g/day) for individuals with moderate renal function impairment, and 13.53 g/day (95%CI: 7.20 to 19.86 g/day) for individuals with severe renal function impairment; P <0.001 for subgroup differences]. Conclusions SGLT2i-mediated UGE was renal function dependent, which was decreased with the extent of renal function impairment.
Ten Years After SINS: Role of Surgery and Radiotherapy in the Management of Patients With Vertebral Metastases

The objective of the different types of treatments for a spinal metastasis is to provide the best oncological and functional result with the least aggressive side effects. Initially created in 2010 to help clinicians in the management of vertebral metastases, the Spine Instability Neoplastic Score (SINS) has quickly found its place in the decision making and the treatment of patients with metastatic spinal disease. Here we conduct a review of the literature describing the different changes that occurred with the SINS score in the last ten years. After a brief presentation of the spinal metastases’ distribution, with or without spinal cord compression, we present the utility of SINS in the radiological diagnosis and extension of the disease, in addition to its limits, especially for scores ranging between 7 and 12. We take this opportunity to expose the latest advances in surgery and radiotherapy concerning spinal metastases, as well as in palliative care and pain control. We also discuss the reliability of SINS amongst radiologists, radiation oncologists, spine surgeons and spine surgery trainees. Finally, we will present the new SINS-derived predictive scores, biomarkers and artificial intelligence algorithms that allow a multidisciplinary approach for the management of spinal metastases.
Evaluation of Shifts in the Potential Future Distributions of Carcharhinid Sharks Under Different Climate Change Scenarios

Climate change is currently considered one of the main phenomena affecting marine species through expansion or contraction of their distribution. Being ectothermic organisms, sharks of the family Carcharhinidae could be highly susceptible to the effects of climate change. These sharks are of great ecological importance, which is reflected in their role in the integrity of coastal and oceanic ecosystems as top predators that act to maintain the stability of the food chain, as well as providing economic value through fishing, consumption, and ecotourism. Currently, their populations are threatened by fishing pressure and anthropogenic activities, including meeting the demand for shark fins. Despite the ecological and economical importance of carcharhinid sharks, knowledge regarding how they are impacted by climate change remains scarce. Ecological niche modeling is a tool that allows analysis of future potential distributions under different climate change scenarios and could contribute to future planning activities and improved conservation outcomes for sharks. We generated models in Maxent in order to predict the potential geographic distribution of 25 carcharhinid sharks that inhabit Mexican waters, projecting this onto future climate change scenarios (RCP2.6, RCP4.5, RCP6.0, and RCP8.5) to calculate the potential losses and gains in their distribution areas by the year 2050. The greatest shifts in suitable areas were observed for the sharks Triaenodon obesus (gained area) and Carcharhinus porosus (lost area). Overall, under all four RCP future scenarios, six species presented gains in suitable area and 19 species presented losses. The greatest loss of suitable area for carcharhinid sharks was found with RCP8.5; however, under this high-emissions global warming scenario, seven species actually showed an increase in distribution area. Our results therefore indicate that climate change could reduce suitable areas for most of the species by 2050. Assessment of the distribution of shark species under climate change is urgently required in order to prioritize conservation efforts toward the most vulnerable species and to ensure the natural function of marine ecosystems, thus maintaining the important ecosystem services they provide to human society.
Nominal Word Order Typology in Signed Languages

Although spoken language nominal typology has been subject to much scrutiny, research on signed language nominal word order typology is still a burgeoning field. Yet, the structure of signed languages has important implications for the understanding of language as a human faculty, in addition to the types of universals that may exist across the world’s languages and the influence of language modality on linguistic structure. This study examines the order of nouns and attributive modifiers (adjectives, numerals, demonstratives, quantifiers, genitives, and relative clauses) in 41 signed languages, which span national and village signed languages from various lineages and geographic regions. Despite previous typological research on clausal phenomena indicating that the clausal structure of signed languages differs systematically from spoken languages (Napoli and Sutton-Spence, 2014, among others), the results of this survey indicate that signed language nominal word order typology is strikingly similar to spoken languages in several ways: 1) the most common word orders in spoken languages are also common in signed languages, 2) the uncommon word orders in spoken languages are also uncommon in signed languages, but are attested, unlike uncommon major constituent orders, and 3) the relative ranking of word order strategies, particularly relative clauses, is similar across signed and spoken languages.
Do Local Habitat Conditions Affect Estimates of Relative Pollen Productivity and Source Area in Heathlands?

Relative Pollen Productivity is an essential parameter for quantitative reconstruction of past land cover from pollen records, but published studies have produced a range of different values for the same taxa. Heathland habitats have limited plant diversity and strong spatial patterning, therefore are useful case studies to investigate aspects of pollen dispersal and deposition, but the estimated spatial area “sensed” by pollen records in these habitats also varies widely between studies. In this study, we estimate pollen productivity from two different microhabitats in a heathland ecosystem in order to investigate the role of local environmental conditions in any observed differences. Vegetation survey was carried out using the Crackles Bequest Project method, pollen assemblages from moss samples counted using standard methods, and relative pollen productivity and estimated source area derived using Extended R-Value analysis. Analysis of the data suggests that at least two pollen source areas exist at the sites studied, reflecting scales of landscape organisation. Microhabitat does not appear to have a marked effect on estimates of Relative Pollen Productivity in this heathland system. This study confirms earlier findings that the estimates obtained for some taxa from heathlands are substantially different than those from agricultural landscapes, especially Poaceae. The findings suggest that the factors controlling Relative Pollen Productivity are still not fully understood, and that differences between locations may reflect real, habitat-led differences. Further investigation of this parameter, which is central to reconstruction of past land cover from pollen records whether overtly incorporated via an algebraic model or less explicitly present via ecological narrative, biomisation or modern analog approaches, is clearly necessary.
Investigation of Correlations Between Optical Coherence Tomography Biomarkers and Visual Acuity in X-Linked Retinoschisis

Purpose To investigate the imaging biomarkers of spectral-domain optical coherence tomography (SD-OCT) and their correlations with age and best-corrected visual acuity (BCVA) in patients with X-linked retinoschisis (XLRS). Methods OCT images of 72 eyes of 39 patients with confirmed XLRS were obtained to assess imaging biomarkers, including but not limited to the automatic evaluation of foveal thickness, central subfield thickness (CST), macular volume, and the manual measurement of area of macular schisis cavity (AMS). Correlations between age/BCVA and all OCT parameters were computed as well. Results In this study, median age was 10.5 (8–12) years old and median BCVA was 0.90 (0.70–1.00) logarithm of the minimum angle of resolution. Macular retinoschisis was found in all affected eyes, with peripheral retinoschisis (PRS) in 34 (47.2%) eyes. Cystic cavities most frequently affected inner nuclear layer (100%) in the macula. Ellipsoid zone (EZ) defects occurred in 53 (73.6%) eyes. As for correlation, BCVA was significantly correlated with several OCT parameters, including CST, AMS, EZ defect, PRS and vitreomacular adhesion, whereas no correlation was found between age and any OCT parameter. Conclusion Explicable OCT imaging biomarkers such as CST, AMS, and photoreceptor defects were identified and may serve as reference parameters or potential regions of interest for future observational and interventional research design and result interpretation.
The Splenic Marginal Zone in Children Is Characterized by a Subpopulation of CD27-Negative, Lowly IGHV-Mutated B Cells

Young children and older adults suffer from enhanced susceptibility to infections with blood-borne pathogens. An essential step towards immunity is the establishment of a splenic marginal zone (sMZ), which is immature at below 2 years of age. At approximately 5 years of age, an adult level of protection is reached but wanes again in older adults. Although the infant sMZ is thought to contain mostly naïve B cells, memory B cells are recruited to and recirculate from the sMZ throughout life, and class-switched sMZ B cells dominate in older adults. For a better resolution of naïve versus memory B-cell subset accumulation in the sMZ, we performed a single cell-based gene expression analysis of (CD21highIgMhigh) sMZ B cells among five healthy donors (age 3 to 48 years) and validated the sMZ B-cell subset composition by flow cytometry of 147 spleen biopsies (age 0 to 82 years). We identified a major sMZ B-cell subpopulation, which is abundant at birth but decreases with age. These cells lack CD27 expression but carry a weak-to-intermediate memory B-cell signature. These CD27neg sMZ B cells are either IGHV-unmutated or carry only a few IGHV mutations early in life but show average memory B-cell IGHV mutation frequencies (>3%) in adults. The activation and proliferation potential of CD27neg sMZ B cells is significantly above that of non-sMZ B cells already in children. Our study suggests that the human sMZ B-cell pool changes with age, encompassing a major population of lowly Ig-mutated CD27neg but antigen-experienced B cells early in life.
Transforming a Concept in a Tool: Diagnostic and Prognostic Value of Tasks Depleting Cognitive Resources

Converging evidence suggests that cognitive resources are limited and depletable. In this opinion paper we will describe how to exploit these characteristics at the clinical level. By using demanding tasks that require participants to fully engage their attentional resources (e.g., dual-tasks), it is more likely to reveal the presence of subtle motor and cognitive deficits and thus achieve high diagnostic and prognostic power. We will describe the potential this approach has for detecting and predicting cognitive deficits along a continuum from normal to pathological functioning, in apparently healthy aging as well as in neuropsychological cases. In addition, we will highlight that thesemore sensitive tasks are also better suited tomimic those complex everyday life contexts where patients, often unaware of their difficulties, are unable to compensate for their deficit. The case for depletion of cognitive resources as a clinical heuristic/tool is discussed.
Role of ROS-Induced NLRP3 Inflammasome Activation in the Formation of Calcium Oxalate Nephrolithiasis

Calcium oxalate nephrolithiasis is a common and highly recurrent disease in urology; however, its precise pathogenesis is still unknown. Recent research has shown that renal inflammatory injury as a result of the cell-crystal reaction plays a crucial role in the development of calcium oxalate kidney stones. An increasing amount of research have confirmed that inflammation mediated by the cell-crystal reaction can lead to inflammatory injury of renal cells, promote the intracellular expression of NADPH oxidase, induce extensive production of reactive oxygen species, activate NLRP3 inflammasome, discharge a great number of inflammatory factors, trigger inflammatory cascading reactions, promote the aggregation, nucleation and growth process of calcium salt crystals, and ultimately lead to the development of intrarenal crystals and even stones. The renal tubular epithelial cells (RTECs)-crystal reaction, macrophage-crystal reaction, calcifying nanoparticles, endoplasmic reticulum stress, autophagy activation, and other regulatory factors and mechanisms are involved in this process.
Targeting the microRNA-34a as a Novel Therapeutic Strategy for Cardiovascular Diseases

Cardiovascular diseases (CVDs) are still the main cause of morbidity and mortality worldwide and include a group of disorders varying from vasculature, myocardium, arrhythmias and cardiac development. MicroRNAs (miRs) are endogenous non-coding RNAs with 18–23 nucleotides that regulate gene expression. The miR-34 family, including miR-34a/b/c, plays a vital role in the regulation of myocardial physiology and pathophysiological processes. Recently, miR-34a has been implicated in cardiovascular fibrosis, dysfunction and related cardiovascular disorders as an essential regulator. Interestingly, there is a pivotal link among miR-34a, cardiovascular fibrosis, and Smad4/TGF-β1 signaling. Notably, both loss-of-function and gain-of-function approaches identified the critical roles of miR-34a in cardiovascular apoptosis, autophagy, inflammation, senescence and remodeling by modulating multifunctional signaling pathways. In this article, we focus on the current understanding of miR-34a in biogenesis, its biological effects and its implications for cardiac pathologies including myocardial infarction, heart failure, ischaemia reperfusion injury, cardiomyopathy, atherosclerosis, hypertension and atrial fibrillation. Thus, further understanding of the effects of miR-34a on cardiovascular diseases will aid the development of effective interventions. Targeting for miR-34a has emerged as a potential therapeutic target for cardiovascular dysfunction and related diseases.
Changes in Sensorimotor Connectivity to dI3 Interneurons in Relation to the Postnatal Maturation of Grasping

Primitive reflexes are evident shortly after birth. Many of these reflexes disappear during postnatal development as part of the maturation of motor control. This study investigates the changes of connectivity related to sensory integration by spinal dI3 interneurons during the time in which the palmar grasp reflex gradually disappears in postnatal mice pups. Our results reveal an increase in GAD65/67-labeled terminals to perisomatic Vglut1-labeled sensory inputs contacting cervical and lumbar dI3 interneurons between postnatal day 3 and day 25. In contrast, there were no changes in the number of perisomatic Vglut1-labeled sensory inputs to lumbar and cervical dI3 interneurons other than a decrease between postnatal day 15 and day 25. Changes in postsynaptic GAD65/67-labeled inputs to dI3 interneurons were inconsistent with a role in the sustained loss of the grasp reflex. These results suggest a possible link between the maturation of hand grasp during postnatal development and increased presynaptic inhibition of sensory inputs to dI3 interneurons.
Effect of the Seasonal Climatic Variations on the Accumulation of Fruit Volatiles in Four Grape Varieties Under the Double Cropping System

The double cropping system has been widely applied in many subtropical viticultural regions. In the 2-year study of 2014–2015, four grape varieties were selected to analyze their fruit volatile compounds in four consecutive seasons in the Guangxi region of South China, which had a typical subtropical humid monsoon climate. Results showed that berries of winter seasons had higher concentrations of terpenes, norisoprenoids, and C6/C9 compounds in “Riesling,” “Victoria,” and “Muscat Hamburg” grapes in both of the two vintages. However, in the “Cabernet Sauvignon” grapes, only the berries of the 2014 winter season had higher terpene concentrations, but lower norisoprenoid concentrations than those of the corresponding summer season. The Pearson correlation analysis showed the high temperature was the main climate factor that affected volatile compounds between the summer and winter seasons. Hexanal, γ-terpinene, terpinen-4-ol, cis-furan linalool oxide, and trans-pyran linalool oxide were all negatively correlated with the high-temperature hours in all of the four varieties. Transcriptome analysis showed that the upregulated VviDXSs, VviPSYs, and VviCCDs expressions might contribute to the accumulations of terpenes or norisoprenoids in the winter berries of these varieties. Our results provided insights into how climate parameters affected grape volatiles under the double cropping system, which might improve the understanding of the grape berries in response to the climate changes accompanied by extreme weather conditions in the future.
Crosstalk Between the Gut Microbiota and Epithelial Cells Under Physiological and Infectious Conditions

The gastrointestinal tract (GIT) is considered the largest immunological organ, with a diverse gut microbiota, that contributes to combatting pathogens and maintaining human health. Under physiological conditions, the crosstalk between gut microbiota and intestinal epithelial cells (IECs) plays a crucial role in GIT homeostasis. Gut microbiota and derived metabolites can compromise gut barrier integrity by activating some signaling pathways in IECs. Conversely, IECs can separate the gut microbiota from the host immune cells to avoid an excessive immune response and regulate the composition of the gut microbiota by providing an alternative energy source and releasing some molecules, such as hormones and mucus. Infections by various pathogens, such as bacteria, viruses, and parasites, can disturb the diversity of the gut microbiota and influence the structure and metabolism of IECs. However, the interaction between gut microbiota and IECs during infection is still not clear. In this review, we will focus on the existing evidence to elucidate the crosstalk between gut microbiota and IECs during infection and discuss some potential therapeutic methods, including probiotics, fecal microbiota transplantation (FMT), and dietary fiber. Understanding the role of crosstalk during infection may help us to establish novel strategies for prevention and treatment in patients with infectious diseases, such as C. difficile infection, HIV, and COVID-19.
Genome-Wide Association Study of Ustekinumab Response in Psoriasis

Heterogeneous genetic and environmental factors contribute to the psoriasis phenotype, resulting in a wide range of patient response to targeted therapies. Here, we investigate genetic factors associated with response to the IL-12/23 inhibitor ustekinumab in psoriasis. To date, only HLA-C*06:02 has been consistently reported to associate with ustekinumab response in psoriasis. Genome-wide association testing was performed on the continuous outcome of percent change in Psoriasis Area Severity Index (PASI) at 12 weeks of ustekinumab therapy relative to baseline. A total of 439 European ancestry individuals with psoriasis were included [mean age, 46.6 years; 277 men (63.1%)]. 310 (70.6%) of the participants comprised the discovery cohort and the remaining 129 (29.4%) individuals comprised the validation cohort. Chromosome 4 variant rs35569429 was significantly associated with ustekinumab response at 12 weeks at a genome-wide significant level in the discovery cohort and replicated in the validation cohort. Of psoriasis subjects with at least one copy of the deletion allele of rs35569429, 44% achieved PASI75 (75% improvement in PASI from baseline) at week 12 of ustekinumab treatment, while for subjects without the deletion allele, 75% achieved PASI75 at week 12. We found that differences in treatment response increased when rs35569429 was considered alongside HLA-C*06:02. Psoriasis patients with the deletion allele of rs35569429 who were HLA-C*06:02 negative had a PASI75 response rate of 35% at week 12, while those without the deletion allele who were HLA-C*06:02 positive had a PASI75 response rate of 82% at week 12. Through GWAS, we identified a novel SNP that is potentially associated with response to ustekinumab in psoriasis.
Neuroticism as Mediator and Moderator Between War Atrocities and Psychopathology in Syrian Refugee Children and Adolescents

Background Despite the extensive research on war atrocities and risk factors for psychopathology, there is a paucity of research on the potential mediating and moderating effect of neuroticism in refugee children and adolescents. Objective This study aimed to analyze whether neuroticism mediated and/or moderated the relationship between war atrocities and different types of psychopathology in Syrian refugee children and adolescents who resettled in Lebanon and Jordan. Participants and Setting Participants were 1,000 Syrian refugee children and adolescents of both sexes. Methods Questionnaires were administered in an interview format with children at school by two trained psychologists. Descriptive statistics and inter-correlations among variables were used Then the mediator and moderator effect of neuroticism in the relationship between war atrocities and posttraumatic stress, emotion regulation and behavioral and emotional disorders were examined. Results A partial mediating effect of neuroticism on posttraumatic stress disorder (PTSD), emotion dysregulation, and emotional and behavioral disorders was revealed. Findings also indicated full moderating effects of neuroticism on PTSD as well as partial moderating effects on emotion dysregulation, and emotional and behavioral. Conclusions Findings contribute to the neuroticism literature by showing that high-N children develop more problems that are psychopathological and have more severe affective reactions to war atrocities in post- resettlement contexts. Early interventions aimed to reduce neuroticism might contribute to a better prognosis in refugee children at high-risk for psychological disorders.