Miracle-dz/UniFAR-FTUs huggingface dataset:
Role of Tau protein in long COVID and potential therapeutic targets

Introduction Long COVID is an emerging public health burden and has been defined as a syndrome with common symptoms of fatigue, shortness of breath, cognitive dysfunction, and others impacting day-to-day life, fluctuating or relapsing over, occurring for at least two months in patients with a history of probable or confirmed SARS CoV-2 infection; usually three months from the onset of illness and cannot be explained by an alternate diagnosis. The actual prevalence of long-term COVID-19 is unknown, but it is believed that more than 17 million patients in Europe may have suffered from it during pandemic. Pathophysiology Currently, there is limited understanding of the pathophysiology of this syndrome, and multiple hypotheses have been proposed. Our literature review has shown studies reporting tau deposits in tissue samples of the brain from autopsies of COVID-19 patients compared to the control group, and the in-vitro human brain organoid model has shown aberrant phosphorylation of tau protein in response to SARS-CoV-2 infection. Tauopathies, a group of neurodegenerative disorders with the salient features of tau deposits, can manifest different symptoms based on the anatomical region of brain involvement and have been shown to affect the peripheral nervous system as well and explained even in rat model studies. Long COVID has more than 203 symptoms, with predominant symptoms of fatigue, dyspnea, and cognitive dysfunction, which tauopathy-induced CNS and peripheral nervous system dysfunction can explain. There have been no studies up till now to reveal the pathophysiology of long COVID. Based on our literature review, aberrant tau phosphorylation is a promising hypothesis that can be explored in future studies. Therapeutic approaches for tauopathies have multidimensional aspects, including targeting post-translational modifications, tau aggregation, and tau clearance through the autophagy process with the help of lysosomes, which can be potential targets for developing therapeutic interventions for the long COVID. In addition, future studies can attempt to find the tau proteins in CSF and use those as biomarkers for the long COVID.
The Impact of Individual Characteristics and Organization Culture on Performance and Career Development of Employees Case studies Five Star Hotel in Surabaya Indonesia

This research examines the impact of individual characteristics, organizational culture implementation toward performance and career improvement of the employees at Five Star Hotels Surabaya in Indonesia. This research was conducted at five star hotels in Surabaya which covered 100 employees as respondent. This research by utilizing Structural Equation Modelling (SEM), the technique was processed with AMOS program to analyze some hypothesis. The result of this research were empirical date of the development of the theoretical of human resources and practice management. The inter-correlations models between these variables in this study revealed that five hypothesis have significant correlation.
Recent Advances in Cancer Immunotherapy with a Focus on FDA-Approved Vaccines and Neoantigen-Based Vaccines

Cancer immunotherapies refer to the concept of retraining the immune system to target malignant cells. Multiple immunotherapeutic options exist including immune modulating antibodies, immune stimulating cytokines, chimeric antigen receptor T cell therapy, and vaccines. Overall, this field has advanced rapidly as knowledge of the tumor microenvironment, immunological pathways, and biotechnology expands. Specifically, advancements in neoantigen identification, characterization, and formulation into a vaccine show promise. This review is focused on previously United States Food and Drug Administration-approved cancer therapeutic vaccines and neoantigen-based vaccine developments along with the associated relevant clinical trials.
Yield and Mineral Composition among Mungbean [Vigna radiata (L.) R. Wilczek] Genotypes Grown in Different Agroecologies in East Africa

Mungbean [Vigna radiata (L.) R. Wilczek var. radiata] also referred to as green gram is a key crop especially in the marginal areas of East Africa. It is rich in micronutrients and protein and thus can help ameliorate malnutrition if incorporated into diets. This study was conducted to evaluate the performance of 26 fixed elite mungbean breeding genotypes for yield and micronutrient composition across different locations in East Africa (Uganda, Kenya, and Tanzania). The genotypes displayed significant variability for nutritional, phenology, and yield-related traits across test environments. Significant genotype effects were observed for most of the traits except for average yield per plant and dry matter content ( P < 0.05). Random effect of environment was significant for all traits, and significant GXE was observed for all traits except for dry matter and iron content ( P < 0.05). Moderate to high broad-sense heritability (H2) was found among traits except for dry matter content which was low (H2 = 10.4%). There was a significant and positive correlation between Fe and Zn (r = 0.58), and Fe and Ca (r = 0.46), indicating the potential to enhance these traits simultaneously through breeding and/or selection. However, the correlation between yield and nutrients (iron, zinc, and calcium) was negative. Environments KAT_SR_2019, KYM_LR_2020, and KYM_LR_2020 were found to be discriminating (informative) and representative of grain yield, calcium, and zinc content, respectively. Genotypes AVMU 1679, AVMU 1685, and AVMU1686 combined both stability and high micronutrient content, while the high yielding and stable genotypes were AVMU 1689, AVMU 1681, and AVMU 16102. The identified genotypes need to be assessed for farmer preference in on-farm trials before they can be recommended for release as new varieties. Additionally, these genotypes will be useful in future breeding efforts as donors aimed at developing nutrient-dense and high yielding mungbean varieties.
capacidad cardio-respiratoria de niños escolares que viven a moderada altitud

cardiorespiratory capacity in children living at moderate altitude objective: t o determine the cardiorespiratory capacity of school children living at moderate altitude. Patients and Method: 795 children (394 children and 401 girls) were selected from urban public schools in arequipa, peru at moderate altitude (2,320 m). anthropometric variables (body mass, height, body fat percentage) and cardiorespiratory capacity were assessed using the course navette test, considering the following categories: deficient, poor, fair, good, very good and excellent. results: The results showed significant differences in all categories (p < 0.05). It was described that the median values of the poor and deficient categories in both gender were lower than what is considered acceptable (p <0.05). it was concluded that 19% of boys and 21% of girls showed low level of cardiorespiratory capacity and a low negative correlation with overweight (r = -0.20 to -0.22) and a moderate negative correlation with obesity (r = -0.39 to -0.42) were described for both genders. conclusions: low levels of cardiorespiratory capacity in boys and girls living at moderate altitude are observed, which is negatively correlated with excess body weight. The results suggest that 1 in 5 children are likely to suffer some type of cardiovascular event. (Key words: cardiorespiratory capacity, kids, school children, moderate altitude). Rev chil pediatr 2014; 85 (2): 188-196
Influence of different water regimes and nutrient management practice for rice production.

Rice is life for major populations of the world and it is deeply embedded in the cultural heritage of societies. Rice is the staple food for more than half of the world populations. India is the one among the countries to develop and commercialize the rice production technology. Scarcity of fresh water resources has threatened the production of the flood-irrigated rice crop. By 2025, 15 out of 75 million hectare of Asia’s flood-irrigated rice crop will experience water shortage (Tuong and Bouman, 2003). To reduce water use of irrigated rice, water saving regimes can be introduced, that aim to reduce non-beneficial water flows from rice field during crop growth namely seepage, percolation and evaporation by alternate wetting and drying (AWD) irrigation and aerobic rice system (Bouman et al., 2005). Nearly 50 per cent gain in food grain productivity seen in recent times has come through adoption of fertilization practices alone. Although the performance of rice was studied under submerged conditions for yield, minimal efforts have been made to study its performance in different soil ecosystems viz., submerged, saturated and aerobic
Cornerstone: A Collection of Scholarly Cornerstone: A Collection of Scholarly and Creative Works for Minnesota and Creative Works for Minnesota

The effect of a distraction-based intervention on positive affect and aggressive and distress-related behaviors during morning activities of daily living in an elderly dementia patient was tested. Concurrently, the effectiveness of distractors chosen by staff and family report as compared to those chosen through a stimulus preference assessment (SPA) was tested. An alternating treatment design was used to implement identified distractors and a direct observation system was used to measure outcomes. Though staff reported increases in positive affect when using an edible chocolate distractor, no significant changes in positive affect or distress related behaviors were noted by the end of the final treatment phase when compared to initial baseline responding. This was likely due, in part, to the participant’s decline in physical health over the course of the study. With regard to the comparison of methods for identifying distractors, data tended to support the usefulness of a SPA for identifying effective distractors over that of family opinion, but was equally as effective as caregiver opinion. Further research is needed to better understand these outcomes.
Oral Molnupiravir and Nirmatrelvir/Ritonavir for the Treatment of COVID-19: A Literature Review with a Focus on Real-World Evidence

Vaccines remain the cornerstone of medical prevention and are highly effective in reducing the risk of severe disease and death due to coronavirus disease 2019 (COVID-19). In the context of expanding the therapeutic armamentarium against COVID-19, molnupiravir (Lagevrio) and ritonavir-boosted nirmatrelvir (Paxlovid) were developed, constituting the first effective oral treatments against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In this narrative review, we retrospectively inquired into the clinical trials and real-world studies investigating the efficacy of these agents. Overall, clinical trials and real-world studies have demonstrated the efficacy of both agents in reducing hospitalization and death rates in COVID-19 patients. As per current recommendations, their use is suggested in patients with mild to moderate symptoms who are at high risk of developing severe disease. Nevertheless, limited data exist regarding their efficacy in specific subpopulations, such as immunocompromised patients, those with severe kidney disease, pregnant women, and children.
Interdecadal changes in snow depth on Arctic sea ice

Snow plays a key role in the growth and decay of Arctic sea ice. In winter, it insulates sea ice from cold air temperatures, slowing sea ice growth. From spring to summer, the albedo of snow determines how much insolation is absorbed by the sea ice and underlying ocean, impacting ice melt processes. Knowledge of the contemporary snow depth distribution is essential for estimating sea ice thickness and volume, and for understanding and modeling sea ice thermodynamics in the changing Arctic. This study assesses spring snow depth distribution on Arctic sea ice using airborne radar observations from Operation IceBridge for 2009–2013. Data were validated using coordinated in situ measurements taken in March 2012 during the Bromine, Ozone, and Mercury Experiment (BROMEX) field campaign. We find a correlation of 0.59 and root-mean-square error of 5.8 cm between the airborne and in situ data. Using this relationship and IceBridge snow thickness products, we compared the recent results with data from the 1937, 1954–1991 Soviet drifting ice stations. The comparison shows thinning of the snowpack, from 35.1 ± 9.4 to 22.2 ± 1.9 cm in the western Arctic, and from 32.8 ± 9.4 to 14.5 ± 1.9 cm in the Beaufort and Chukchi seas. These changes suggest a snow depth decline of 37 ± 29% in the western Arctic and 56 ± 33% in the Beaufort and Chukchi seas. Thinning is negatively correlated with the delayed onset of sea ice freezeup during autumn.
Petrogenesis of the Labrieville Alkalic Anorthosite Massif, Grenville Province, Quebec

The Labrieville massif (>1010 Ma) is an eroded dome consisting mineral—plagioclase feldspar. The circumstances whereby such nearly monomineralic plutons can be produced of three zones: (1) a foliated inner core of pink anorthosite (>An30Or13, >2100 ppm Sr, >1300 ppm Ba) with minor have puzzled geologists for more than a century, and massif anorthosites remain petrologic enigmas. In adleuconorite; (2) a foliated outer core of pink anorthosite (>An35Or10, >1900 ppm Sr, >850 ppm Ba) with more abundant leuconorite; dition to this fundamental aspect of the ‘anorthosite problem’ (see Bowen, 1917; Scoates, 2000), the petro(3) a border of foliated to massive green leucogabbro. Antiperthitic plagioclase, orthopyroxene, hemoilmenite, and small amounts of genesis of massif anorthosites was apparently restricted in time and space. Specifically, virtually all of the world’s biotite are present in all rocks. The border zone contains additional clinopyroxene, magnetite, and apatite. Labrieville is more alkalic supply of massif anorthosite was formed during the Proterozoic, and much of it is found in the Grenville and Srand Ba-rich than almost all other massif anorthosites. The widespread presence of biotite and the high hematite content of Province of Quebec and Labrador (Kranck, 1961; Anderson, 1969; Ashwal, 1993). hemoilmenite suggest crystallization from a relatively oxidizing and water-bearing magma. Collectively, these features imply that Despite their similar plagioclase-rich nature, it is now apparent that massif anorthosites worldwide are minLabrieville originated from a magma that differed considerably from typical tholeiitic liquids. Majorand trace-element variations suggest eralogically and compositionally diverse (see Xue & that all rock types represent mixtures of cumulus minerals, with Morse, 1993), implying involvement of a wide range of negligible trapped melt. The compositionally distinct zones imply parental magma compositions or petrogenetic processes differentiation during crystallization. Although plagioclase comin their formation. However, comprehensive studies on positions become more evolved inward, other indicators (e.g. XMg individual anorthosite complexes that can elucidate their in pyroxene) suggest differentiation outward from core to border. We petrogenesis—combining field and petrographic obfavor the latter interpretation, and suggest that the increase in servations with mineral-chemical data, and with complete plagioclase An content reflects a decline in pressure during crysmajorand trace-element data on a wide range of rock tallization. types—are few in number. Admittedly, the immense size of certain massifs (e.g. Lac St. Jean Complex, Woussen et al., 1988) and the remote or inhospitable locations of
Timing the Hegenshan Suture in the Central Asian Orogenic Belt: New Paleomagnetic and Geochronological Constraints From Southeastern Mongolia

The timing of formation of the Hegenshan suture is crucial to understanding the evolution of the Central Asian Orogenic Belt (CAOB). Here we present a well‐dated paleomagnetic pole (103 samples from 15 sites, 36.7°N/29.2°E, A95 = 3.3°) that passed a positive fold test, a reversal test, and a conglomerate test from the ∼250 Ma upper Gunbayn Formation andesites in the southeastern Mongolia Block (MOB). The high‐quality paleomagnetic database may demonstrate that the MOB drifted rapidly southward and collided with the Xilinhot–Songliao Block between 256 and 250 Ma, resulting in the closure of the Hegenshan Ocean at ∼250 Ma. The Hegenshan suture and the Solonker suture were formed almost simultaneously and marked the final closure of the Paleo‐Asian Ocean.
Security and Reliability Tradeoff of UAV Relays Assisted Cognitive Transmissions With Hardware Impairments

In this article, we analyze the security and reliability tradeoff (SRT) performance of a unmanned aerial vehicle (UAV) relays assisted cognitive network consisting of a cognitive source (S), multiple cognitive UAV relays (Rs), a cognitive destination (D) in the face of an eavesdropper (E). We consider a practical scenario where mutual interference exists between the primary users and cognitive users. In order to protect the wireless transmission against the eavesdropping attack, we propose two UAV relay selection schemes, namely, noninterference aware relay selection (NIARS) scheme and interference aware relay selection (IARS) scheme. Specifically, in the NIARS scheme, a relay having the best instantaneous (R-D) link (spanning from Rs to D) is selected to forward message. By contrast, a relay maximizing the main channel capacity is selected, which relies not only on the channel state informations (CSIs) of main links but also on the CSIs of the interference links. For the purpose of comparison, we present the round robin (RR) scheme as a baseline. To evaluate the SRT performance, we derive the closed-form intercept probability (IP) and outage probability (OP) expressions for RR, NIARS, and IARS schemes under the impact of hardware impairments (HIs) over Nakagami- $m$ fading channels. Numerical results show that the proposed IARS and NIARS schemes perform better than RR scheme in terms of SRT performance. Additionally, the HI at D has a negative impact on SRT performance, while HI at E has a positive impact on SRT performance.
Does Indonesia's High Level of Corruption Affect Its Trade Volume?

This article aims to examine the connection between corruption and the amount of trade in several commodities, including raw materials, capital goods, intermediate products, and consumer goods, with a specific emphasis on the Indonesian situation. Indicators of corruption utilized in this article include the Corruption Perception Index (CPI) and the Control of Corruption (COC). Meanwhile, the sum of Indonesia's exports and imports indicated the country's trade volume. For this issue, this article employs the gravity model and regresses it with either a fixed effect or a random effect model. The empirical findings show that both the CPI and COC levels of corruption in Indonesia have a negative impact on the amount of trade in capital goods. However, only the CPI shows a negative correlation with the prevalence of corruption in Indonesia, whereas consumer products, intermediate goods, and raw materials all show a positive correlation. The impact of COC on Indonesia's trade partners is complicated for the commodities this article looked at. The insights generated from this study hold significant value in shaping a more informed and accurate representation of how corruption permeates and impacts international trade dynamics, thus contributing to a more nuanced understanding of this critical issue.JEL Classification: D73, F10, C01How to Cite:Yunan, Z. Y. (2023). Does Indonesia’s High Level of Corruption Affects Its Trade Volume? Signifikan: Jurnal Ilmu Ekonomi, 12(2), 425-440. https://doi.org/10.15408/sjie.v12i2. 35156.
Regional Convergence within the EU-25: A Spatial Econometric Analysis

study investigates absolute convergence within the EU-25 for the time period 1995-2002. It is shown that growth performance and convergence depend crucially on the development of a region's surrounding. The detected spatial autocorrelation is of substantive form indicating that least squares estimation of the absolute convergence model yields biased results. A yearly convergence rate of 0.7% to 0.9% is estimated by using a spatial autoregressive model specification. Several robustness checks are carried out: First, it is examined whether the functional relationship of the convergence equation is stable over space. Secondly, the sensitivity of the estimation results on the specified weight matrix is investigated. Third, the paper identifies the source of spatial dependence. 1. Introduction the 1990s considerable attention has been drawn to the question of regional income convergence in Europe. A lot of quantitative research has been conducted, and several new theoretical approaches have been proposed. A similarity of most studies is the neglected spatial interaction of the underlying observations. Now, there seems to be wide-spread agreement that spatial dependencies should be taken into account when analyzing growth. Recent studies suggest that geographic location does matter for a region's growth performance and consequently its pace of convergence. Spatial interactions such as technological spillovers 1 or factor mobility, both being important forces for the process of convergence, should not be neglected. There are two ways to deal with this phenomenon using standard econometric techniques: The data can be either nationally weighted or country dummy variables can be incorporated in the regression equation. Indeed, as this study will show, a great extent of spatial correlation is based on country-specific 1 See Lopez-Bazo et al. (2004) for a spatial econometric estimation of technological
Secondary Current of Saline Underflow In A Highly Meandering Channel: Experiments and Theory

The flow of deep-sea turbidity currents in meandering channels has been of considerable recent interest. Here we focus on the secondary flow associated with a subaqueous bottom current in a meandering channel. For simplicity, a saline bottom current may be used as a surrogate for a turbidity current driven by a dilute suspension of fine-grained sediment that does not easily settle out. In the case of open channel flow, i.e. rivers, the classical Rozovskiian paradigm is often invoked to explain secondary flow in meandering channels. This paradigm indicates that the near-bottom secondary flow in a bend is directed inward, i.e. toward the inner bank. It has recently been suggested based on experimental and theoretical considerations, however, that this pattern is reversed in the case of subaqueous bottom flows in meandering channels, so that the near-bottom secondary flow is directed outward (reversed secondary flow), towards the outer bank. Experimental results presented here, on the other hand, indicate near-bottom secondary flows that have the same direction as observed in a river (normal secondary flow). The implication is an apparent contradiction between experimental results. We use theory, experiments and reconstructions of case studies from fieldscale flows to resolve this apparent contradiction based on the densimetric Froude number of the flow. We find three ranges of densimetric Froude number, such that a) in an upper regime, secondary flow is reversed, b) in a middle regime, it is normal and c) in a lower regime, it is reversed. We apply our results at field scale to previous studies on channel-forming turbidity currents in the Amazon submarine canyon-fan system (Amazon Channel) and the Monterey canyon and a saline underflow in the Black Sea flowing from the Bosphorus. Our analysis indicates that secondary flow should be normal throughout most of the Amazon submarine fan reach, lower-regime reversed in the case of the Black Sea underflow, and upperregime reversed in the case of the Monterey canyon. The theoretical analysis predicts both normal and reversed regimes in the Amazon submarine canyon reach.