Running Head: Genetic Correlations: Brain & Immune Phenotypes-1 1 Title: Genetic correlations among neuro-behavioral and immune-related phenotypes based on genome-

Author List: Daniel S. Tylee, Jiayin Sun, Jonathan L. Hess, 1 Muhammad A. Tahir, 1 Esha Sharma, Rainer Malik, Bradford B. Worrall,3 Andrew J. Levine, 4 Jeremy J. Martinson, Sergey Nejentsev, Doug Speed, Annegret Fischer, Eric Mick, Brian R. Walker, Andrew Crawford, Struan F.A. Grant, Constantin Polychronakos, Jonathan P. Bradfield, Patrick M. A. Sleiman, Hakon Hakonarson, Eva Ellinghaus, James T. Elder, Lam C. Tsoi, Richard C. Trembath, Jonathan N. Barker, Andre Franke, Abbas Dehghan, The 23andMe Research Team, The Inflammation Working Group of the CHARGE Consortium, The METASTROKE Consortium of the International Stroke Genetics Consortium, The Netherlands Twin Registry, The neuroCHARGE Working Group, The Obsessive Compulsive and Tourette Syndrome Working Group of the Psychiatric Genomics Consortium, Stephen V. Faraone, and Stephen J. Glatt. 1 Psychiatric Genetic Epidemiology & Neurobiology Laboratory (PsychGENe Lab); Departments of Psychiatry and Behavioral Sciences & Neuroscience and Physiology; SUNY Upstate Medical University; Syracuse, NY, U.S.A. 2 Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-University (LMU), Munich, Germany. 3 Departments of Neurology and Public Health Sciences, University of Virginia School of Medicine, Charlottesville, VA, U.S.A. 4 Department of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, U.S.A. 5 Department of Infectious Diseases and Microbiology, Graduate School of Public Health, University of Pittsburgh, PA, U.S.A. 6 Department of Medicine, University of Cambridge, Cambridge, U.K. 7 Genetics Institute, University College London, London, WC1E 6BT, U.K. 8 Institute of Clinical Molecular Biology, Christian Albrechts University of Kiel, Kiel, Germany. 9 Department of Quantitative Health Sciences, University of Massachusetts Medical School, Worcester, MA, U.S.A. 10 BHF Centre for Cardiovascular Science, Queen’s Medical Research Institute, University of Edinburgh, Edinburgh, EH16 4TJ, U.K. 11 School of Social and Community Medicine, MRC Integrated Epidemiology Unit, University of Bristol, Bristol, BS8 2BN, UK 12 Center for Applied Genomics, Division of Human Genetics, The Children’s Hospital of Philadelphia, Philadelphia, PA, U.S.A. 13 Division of Endocrinology and Diabetes, The Children’s Hospital of Philadelphia, Philadelphia, PA, U.S.A. 14 Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, U.S.A. 15 Institute of Diabetes, Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, U.S.A. 16 Endocrine Genetics Laboratory, Department of Pediatrics and the Child Health Program of the Research Institute, McGill University Health Centre, Montreal, Quebec, Canada. 17 Quantinuum Research LLC, San Diego, CA, U.S.A. 18 Department of Dermatology, Veterans Affairs Hospital, University of Michigan, Ann Arbor, Michigan, United States of America 19 Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, United States of America. 20 Division of Genetics and Molecular Medicine, King's College London, London, UK 21 Department of Biostatistics and Epidemiology, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London 22 23andMe, Inc., Mountain View, CA, USA 23 K.G. Jebsen Centre for Research on Neuropsychiatric Disorders, University of Bergen, Bergen, Norway