Miracle-dz/UniFAR-FTUs huggingface dataset:
Distributed optimization for cognitive radio networks using Stackelberg game

This paper considers frequency-division spatial spectrum sharing (FD-SSS) based cognitive radio (CR) networks. In this network, the spectrum of primary users (PU) can be divided into a number of sub-bands each of which can only be accessed by one secondary user (SU). This setting combines both advantages of spatial spectrum sharing and temporal spectrum sharing methods. However, there are three major problems for this system: 1) how to optimally allocate the available subbands to all SUs, 2) how to distributively optimize the transmit powers for SUs to maintain the received interference power of PUs, 3) how to control the accessibility of SUs in the licensed spectrum. In this paper, we introduce a Stackelberg game based hierarchical framework to optimize the performance of FD-SSS based CR networks. More importantly, we show that, by using a simple pricing function for PUs, the above three problems can be solved simultaneously. We prove that the proposed game has a unique Stackelberg equilibrium (SE) and then introduce a simple distributed algorithm to let SUs and PUs converge to the SE. Comparing to the existing results, our setting does not require SUs to communicate with each other or to know the interference temperature of PUs.
A novel inhibitory nucleo-cortical circuit controls cerebellar Golgi cell activity

The cerebellum, a crucial center for motor coordination, is composed of a cortex and several nuclei. The main mode of interaction between these two parts is considered to be formed by the inhibitory control of the nuclei by cortical Purkinje neurons. We now amend this view by showing that inhibitory GABA-glycinergic neurons of the cerebellar nuclei (CN) project profusely into the cerebellar cortex, where they make synaptic contacts on a GABAergic subpopulation of cerebellar Golgi cells. These spontaneously firing Golgi cells are inhibited by optogenetic activation of the inhibitory nucleo-cortical fibers both in vitro and in vivo. Our data suggest that the CN may contribute to the functional recruitment of the cerebellar cortex by decreasing Golgi cell inhibition onto granule cells. DOI: http://dx.doi. org/10.7554/eLife.06262. 001
Auditory Hallucinations and the Brain’s Resting-State Networks: Findings and Methodological Observations

© The Author 2016. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. Auditory Hallucinations and the Brain’s Resting-State Networks: Findings and Methodological Observations
No evidence that preferences for facial masculinity track changes in women's hormonal status

Although widely cited as strong evidence that sexual selection has shaped human facial attractiveness judgments, evidence that preferences for masculine characteristics in men's faces are related to women's hormonal status is equivocal and controversial. Consequently, we conducted the largest ever longitudinal study of the hormonal correlates of women's preferences for facial masculinity (N=584). Analyses showed no evidence that preferences for facial masculinity were related to changes in women's salivary steroid hormone levels. Furthermore, both within-subject and between-subject comparisons showed no evidence that oral contraceptive use decreased masculinity preferences. However, women generally preferred masculinized over feminized versions of men's faces, particularly when assessing men's attractiveness for short-term, rather than long-term, relationships. Our results do not support the hypothesized link between women's preferences for facial masculinity and their hormonal status.
Intra-arterial transplantation of allogeneic mesenchymal stem cells mounts 1 neuroprotective effects in a transient ischemic stroke model in rats : Analyses of 2 therapeutic time window and its mechanisms 3 4

Intra-arterial transplantation of allogeneic mesenchymal stem cells mounts 1 neuroprotective effects in a transient ischemic stroke model in rats: Analyses of 2 therapeutic time window and its mechanisms 3 4 Atsuhiko Toyoshima, Takao Yasuhara, Masahiro Kameda, Jun Morimoto, Hayato 5 Takeuchi, Feifei Wang, Tatsuya Sasaki, Susumu Sasada, Aiko Shinko, Takaaki 6 Wakamori, Mihoko Okazaki, Akihiko Kondo, Takashi Agari, Cesario V. Borlongan, 7 Isao Date 8 1) Department of Neurological Surgery, Okayama University Graduate School of Medicine, 9 Dentistry and Pharmaceutical Sciences 10 Address: 2-5-1, Shikata-cho, Kita-ku, Okayama, 700-8558, JAPAN 11 2) Center for Innovative and Translational Medicine, Kochi University Medical School 12 Address: Kohasu, Oko-cho, Nankoku, Kochi 783-8505, JAPAN 13 3) Department of Neurosurgery, University of South Florida College of Medicine 14 Address: 12901 Bruce B Downs Blvd, Tampa, Florida 33612, United States of America 15 16 Corresponding author 17
Real space and represented space: Cross-cultural perspectives

Abstract This paper examines the contribution of cross-cultural studies to our understanding of the perception and representation of space. A cross-cultural survey of the basic difficulties in understanding pictures—ranging from the failure to recognise a picture as a representation to the inability to recognise the object represented in the picture— indicates that similar difficulties occur in pictorial and nonpictorial cultrues. The experimental work on pictorial space derives from two distinct traditions: the study of picture perception in “remote” populations and the study of the perceptual illusions. A comprison of the findings on pictorial space perception with those on real space perceptual illusions. A comparison of findings on pictorial space perception with those on real space perception and perceptual constancy suggersts that cross-cultural differences in the perception of both real and representational space involve two different types of skills: those related exclusively to either real space or representational space, and those related to both. Different cultural groups use different skills to perform the same perceptual tasks.
Chromatin-associated RNA sequencing (ChAR-seq) maps genome-wide RNA-to-DNA contacts

RNA is a critical component of chromatin in eukaryotes, both as a product of transcription, and as an essential constituent of ribonucleoprotein complexes that regulate both local and global chromatin states. Here we present a proximity ligation and sequencing method called Chromatin-Associated RNA sequencing (ChAR-seq) that maps all RNA-to-DNA contacts across the genome. ChAR-seq provides unbiased, de novo identification of targets of chromatin-bound RNAs including nascent transcripts, chromosome-specific dosage compensation ncRNAs, and genome-wide trans-associated RNAs involved in co-transcriptional RNA processing.
Machine Learning in International Trade Research (cid:150) Evaluating the Impact of Trade Agreements (cid:3)

Modern trade agreements contain a large number of provisions besides tari⁄ reductions, in areas as diverse as services trade, competition policy, trade-related investment measures, or public procurement. Existing research has struggled with over(cid:133)tting and severe multicollinearity problems when trying to estimate the e⁄ects of these provisions on trade (cid:135)ows. In this paper, we build on recent developments in the machine learning and variable selection literature to propose novel data-driven methods for selecting the most important provisions and quantifying their impact on trade (cid:135)ows. The proposed methods have the advantage of not requiring ad hoc assumptions on how to aggregate individual provisions and o⁄er improved selection accuracy over the standard lasso. We (cid:133)nd that provisions related to technical barriers to trade, antidumping, trade facilitation, subsidies, and competition policy are associated with enhancing the trade-increasing e⁄ect of trade agreements.
Barrier Systems for Waste Disposal Facilities

1. Basic Concepts. 2. Leachate Characteristics and Collection. 3. Clay Liners: Compaction, Hydraulic Conductivity and Clay Mineralogy. 4. Clay/Leachate Compatibility by Measurement of Hydraulic Conductivity. 5. Flow Modelling. 6. Chemical Transfer by Diffusion. 7. Contaminant Transport Modelling. 8. Evaluation of Diffusion and Distribution Coefficients. 9. Field Studies of Diffusion and Hydraulic Conductivity. 10. Contaminant Migration in Intact Porous Media: Analysis and Design Considerations. 11. Migration in Fractured Media: Analysis and Design Considerations. 12. Geosynthetic Clay Liners (GCLs). 13. Geomembrane Liners. 14. Covers. 15. Geotechnical and Related Design Issues. 16. Integration of Hydrogeology and Engineering in Barrier Design and Impact Assessment. Index.
Closing wilderness campsites| Visitor use problems and ecological recovery in the Selway-Bitterroot Wilderness, Montana

Ranz, Beth, M.S., March, 1979 Resource Conservation Closing Wilderness Campsites; V is itor Use Problems and Ecological Recovery in the Selway-Bitterroot Wilderness, Montana (123 pp) Director: Sidney S. Frissell The purpose of this study was to describe the effects of closing Wilderness campsites to v is ito r use by 1 ) surveying Wilderness managers in the Northern Rocky Mountains, 2) studying v is ito r use, and 3) measuring the amount of ground cover recovery on closed camp­ sites at Big Creek Lake in the Selway-Bitterroot Wilderness of Western Montana. Questionnaires were sent to 41 Forest Service managers and nine National Park Service managers. Thirty percent of the managers re­ ported having closed campsites, while an additional 10 percent reported planning to close campsites in the future. V is itor use was observed around Big Creek Lake during the summer of 1977. Sixteen percent of the v is ito r groups camped in closed areas. Twenty-two campsites were identified around Big Creek Lake, including seven campsites that developed as a result of closing the other camp­ sites. Ground cover ( i . e . , percent cover of vegetation, natural l i t t e r , bare s o il, and individual plant species) was sampled on the campsites and six natural areas. A comparison was made between ground cover on closed campsites, and open established campsites. The closed campsites had 14.7 percent more vegetation cover, and had a d ifferent plant composition than open campsites. A trend study was done on the campsite vegetation using Forest Service vertical photographs taken in 1975 and 1977. Vegetation cover in­ creased an average 8.8 percent on closed campsites, while vegetation cover on open campsites averaged a zero change. Closing Wilderness campsites has the following problems, 1) a ll vis itors do not comply with the closures, 2) ecological damage occurs elsewhere with the formation of new campsites, and 3) recovery is slow re lative to the time i t takes for damage to occur.
Reconstituted high density lipoprotein inhibits physiologic and tumor necrosis factor alpha responses to lipopolysaccharide in rabbits.

OBJECTIVE To determine the effect of reconstituted human high density lipoprotein (rHDL) on physiologic and cytokine responses to infusion of lipopolysaccharide. DESIGN A blinded, randomized trial of three preparations of a purified human rHDL with apolipoprotein A-I-phosphatidyl choline-cholesterol molar ratios of 1:100:10, 1:150:10, and 1:200:0 and placebo in a rabbit lipopolysaccharide intravenous infusion model. INTERVENTIONS Groups of six New Zealand white rabbits received either placebo or one of the three human rHDL preparations above as a single, 75-mg/kg (apolipoprotein A-I equivalent) dose intravenously over 10 minutes ending 5 minutes before the start of a 3-hour infusion of lipopolysaccharide. MAIN OUTCOME MEASURES Mean arterial pressure, base excess, and plasma tumor necrosis factor alpha (TNF-alpha) production were determined. RESULTS The human rHDL suppressed TNF-alpha production with the products having the highest fraction of phosphatidyl choline producing the greatest suppression of TNF-alpha production. The human rHDL 1:200:0 group maintained a low, near-baseline TNF-alpha concentration and minimal decline in mean arterial pressure and base excess throughout the lipopolysaccharide infusion in contrast to the placebo group. CONCLUSION Reconstituted human high density lipoprotein appears to be useful in inhibiting the physiologic effects and cytokine release associated with endotoxemia and may provide adjunctive treatment for patients with gram-negative sepsis.
apathy and intrinsic functional connectivity networks in amnestic mild cognitive impairment

Background: Although several prior works reported that apathy is associated with conversion to Alzheimer’s disease in individuals with amnestic mild cognitive impairment (aMCI), effects of apathy on the functional connectivity (FC) of the brain remain unclear. In this study, we assessed the pattern of association between apathy and default mode network (DMN), salience network and central executive network (CEN) in aMCI subjects. Methods: Fifty subjects with aMCI and 50 controls (CONs) participated in this study. They underwent clinical assessments and magnetic resonance imaging for the structural and resting-state scan. We explored the patterns of association between apathy inventory (IA) total score and the whole-brain voxel-wise FCs of the DMN, salience network and CEN in aMCI subjects. Results: We observed that the FCs of the DMN were less and those of CEN were more in the aMCI group than the CON group. Total IA score was negatively correlated with FCs of the anterior cingulate within the DMN, and positively correlated with FCs of the middle frontal, inferior frontal, and supramarginal gyrus within the CEN in the aMCI group. Conclusion: Our findings suggest that distinctive patterns of association between apathy and FCs in the DMN and CEN in the aMCI group might reflect the putative role of functional network change in the development of apathy in aMCI.
Living with cystic fibrosis – a qualitative study of a life coaching intervention

Background: Cystic fibrosis (CF) is a chronic, life-shortening disease with a significant treatment burden. To support young adults with CF in their everyday life, we previously conducted a life coaching feasibility trial (published elsewhere). The aim of the current study was to explore how life coaching was experienced by study participants within the context of their lives with CF. Methods: A qualitative study using individual interviews. Respondents (n = 14) were recruited from the intervention group after participation in life coaching. Data were analyzed from a phenomenologic-hermeneutical perspective, inspired by Ricoeur’s theory. Findings: Periodic exacerbations of CF led to worry about disease progression, and interrupted the respondents’ ability to fulfill daily life roles satisfactory. The treatment burden demanded self-discipline and this was sometimes at the expense of social life or career. The young adults rarely spoke to others about their situation; therefore, they valued opening up to a professional coach about life and concerns. We identified three themes: 1) living an unpredictable life; 2) the conflict between freedom and the constraints of illness; and 3) the value of telling one’s story. In relation to all three themes, coaching promoted reflection over life situations, reframed thoughts, and facilitated finding new ways to manage everyday life. Conclusion: Life coaching is an intervention that is valued for those who feel challenged by their CF disease. Coaching programs should be designed to include the participants, when they feel a need for coaching and are open for change. Screening parameters to identify persons who will most likely benefit from life coaching are needed. to increase risk of
Towards Automated Evaluation of the Quality of Educational Services in HEIs

—The provision of educational services with high quality is a matter of concern to all stakeholders in higher education (academic staff, administration, students, etc.). According to many researchers, student satisfaction is an indicator of service quality in higher education institutions (HEIs), and evaluating the quality of educational and administrative services from students is an effective tool for improving the quality of HEIs. To ensure a competitive benefit over other educational institutions, HEIs leadership should take measures leading to improved student feedback on the quality of the provided administrative and education services, seek ways to exceed student expectations and provide high-quality services. Due to the great importance of the opinion of students on the quality of the services offered, many HEIs develop and use tools to assess student satisfaction with the quality of the services in the HEI. Little researched in the literature is the issue regarding the need to develop tools for HEIs leadership allowing survey results analysis, tracking trends over the years and comparing HEIs results. Based on a detailed analysis of developed questionnaires for evaluating the quality of services, this paper explores the possibilities of automation of the overall process for conducting questionnaire surveys of student’s satisfaction with the quality of services. As a result, a software prototype of a tool to automate the entire process for assessing student satisfaction is proposed - from questionnaire modelling, survey organizing and conducting to the analysis of the collected data. The developed tool allows governing bodies in HEIs to make informed decisions to improve the quality of services and to compare the results with those of competing universities.
Review of the safety and efficacy of imiglucerase treatment of Gaucher disease

: Most patients who suffer from symptomatic Gaucher disease will benefit from enzyme replacement therapy (ERT) with imiglucerase. The safety profile is excellent, only a small percentage of those exposed developing antibodies; similarly, very few patients require pre-medication for allergic reactions. Within 3 to 5 years of imiglucerase therapy, best docu-mented at doses of 30 to 60 units/kg/infusion, hepatosplenomegaly can be expected to be reduced so that the liver volume will be maintained at 1 to 1.5 times normal (30% to 40% reduction from advent of ERT) and spleen volume to  2 to 8 times normal (50% to 60% reduction from advent of ERT). For anemic and thrombocytopenic patients, with 2 to 5 years of imiglucerase, hemoglobin levels are expected to be  11 g/dL for women and children and  12 g/dL for men; and platelet counts in patients with an intact spleen, depending on the baseline value, should approximately be doubled. Bone crises and bone pain but not irreversible skeletal dam-age will improve in most patients. Nonetheless, some features and some symptomatic patients apparently do not respond equally well and/or perhaps inadequately. The benefit for patients with the neuronopathic forms is primarily in improved visceral and hematological signs and symptoms. There are still several unresolved issues, the high per-unit cost being an important one, which have spurred the development of biosimilar enzymes as well as chaperone therapies currently
Cryo-EM structure of the benzodiazepine-sensitive α1β1γ2S tri-heteromeric GABAA receptor in complex with GABA

Fast inhibitory neurotransmission in the mammalian nervous system is largely mediated by GABAA receptors, chloride-selective members of the superfamily of pentameric Cys-loop receptors. Native GABAA receptors are heteromeric assemblies sensitive to many important drugs, from sedatives to anesthetics and anticonvulsant agents, with mutant forms of GABAA receptors implicated in multiple neurological diseases. Despite the profound importance of heteromeric GABAA receptors in neuroscience and medicine, they have proven recalcitrant to structure determination. Here we present the structure of a tri-heteromeric α1β1γ2SEM GABAA receptor in complex with GABA, determined by single particle cryo-EM at 3.1–3.8 Å resolution, elucidating molecular principles of receptor assembly and agonist binding. Remarkable N-linked glycosylation on the α1 subunit occludes the extracellular vestibule of the ion channel and is poised to modulate receptor assembly and perhaps ion channel gating. Our work provides a pathway to structural studies of heteromeric GABAA receptors and a framework for rational design of novel therapeutic agents.
A scoping review of biopsychosocial risk factors and co-morbidities for common spinal disorders

Objective The purpose of this review was to identify risk factors, prognostic factors, and comorbidities associated with common spinal disorders. Methods A scoping review of the literature of common spinal disorders was performed through September 2016. To identify search terms, we developed 3 terminology groups for case definitions: 1) spinal pain of unknown origin, 2) spinal syndromes, and 3) spinal pathology. We used a comprehensive strategy to search PubMed for meta-analyses and systematic reviews of case-control studies, cohort studies, and randomized controlled trials for risk and prognostic factors and cross-sectional studies describing associations and comorbidities. Results Of 3,453 candidate papers, 145 met study criteria and were included in this review. Risk factors were reported for group 1: non-specific low back pain (smoking, overweight/obesity, negative recovery expectations), non-specific neck pain (high job demands, monotonous work); group 2: degenerative spinal disease (workers’ compensation claim, degenerative scoliosis), and group 3: spinal tuberculosis (age, imprisonment, previous history of tuberculosis), spinal cord injury (age, accidental injury), vertebral fracture from osteoporosis (type 1 diabetes, certain medications, smoking), and neural tube defects (folic acid deficit, anti-convulsant medications, chlorine, influenza, maternal obesity). A range of comorbidities was identified for spinal disorders. Conclusion Many associated factors for common spinal disorders identified in this study are modifiable. The most common spinal disorders are co-morbid with general health conditions, but there is a lack of clarity in the literature differentiating which conditions are merely comorbid versus ones that are risk factors. Modifiable risk factors present opportunities for policy, research, and public health prevention efforts on both the individual patient and community levels. Further research into prevention interventions for spinal disorders is needed to address this gap in the literature.