Miracle-dz/UniFAR-FTUs huggingface dataset:
Endocannabinoid Metabolome Characterization of Milk from Guatemalan Women Living in the Western Highlands

ABSTRACT Background Recognized as the gold-standard ideal fare, human milk has a unique composition that meets infants’ needs throughout development. Endocannabinoids and endocannabinoid-like compounds [endocannabinoid metabolome (ECM)] are endogenous lipid mediators derived from long-chain polyunsaturated fatty acids. Based on animal models, it has been proposed that endocannabinoid arachidonoyl glycerol (AG) plays a role in establishing the suckling response during lactation. In addition, endocannabinoid ethanolamides have been shown to stimulate food intake. The mechanisms of action and the role of the ECM in human milk are not fully understood. Objectives The present study aimed to characterize and quantify the ECM in human milk samples from an underserved population in Guatemala. Methods Human milk samples were collected from lactating women (n = 26) for ECM characterization and quantification. Samples were taken at 3 different time points between 4 and 6 mo of lactation during maternal fasting. Human milk samples were analyzed by liquid chromatography-mass spectrometry. Identified members of the ECM were: arachidonoyl ethanolamide, palmitoyl ethanolamide (PEA), oleoyl ethanolamide, docosahexaenoyl ethanolamide, eicoapentaenoyl ethanolamide, eicosenoyl ethanolamide, AG, palmitoyl glycerol, oleoyl glycerol, docosahexaenoyl glycerol, eicosapentaenoyl glycerol, eicosenoyl glycerol, arachidonic acid (ARA), docosahexaenoic acid (DHA), and eicosapentaenoic acid (EPA). Results Overall, concentrations in the ethanolamide group were lower than the glycerols. A time effect was observed for ARA, DHA, EPA, and PEA across the 3 time points (P ≤ 0.05). Conclusions Our study identified the ECM in mature human milk and provides the first report for a population with health disparities within a developing country. The few studies available have been conducted in developed countries. Hypotheses for future studies can be developed based on this study's data to help elucidate specific roles for members of the ECM and how this biological system modulates infant health and development.
Guided Navigation Impairs Spatial Knowledge: Using Aids to Improve Spatial Representations

Successful navigation generally requires an accurate spatial representation of the environment. However, under guided navigation (i.e. route directions are provided by a GPS system or car passenger) no detailed representation of space is necessary because one only needs to follow directions. The first experiment separated components of navigation, spatial decision-making (planning and selection of routes) and navigational control (executing complex actions such as stopping and steering) for environmental learning. Spatial knowledge was assessed using multiple measures (spatial updating using immersive, head-mounted virtual reality and map construction). More accurate environmental knowledge was acquired when spatial decision-making was present at learning, ps < . 001, ds > . 81. No difference in spatial knowledge was found between active navigation and spatial decision-making by itself, ps > . 83, ds < . 07. This finding indicates that the weakened spatial knowledge with control alone (guided navigation) can be explained by the absence of spatial decision-making. Experiments 2 and 3 investigated the use of aids for ameliorating the loss of spatial knowledge for guided navigation with auditory directions. In Experiment 2, guided navigation was augmented using visual aids (primarily egocentric) which reinforced the locations of landmarks. In Experiment 3, guided navigation was augmented by adding cardinal directions (e.g. north), which are exocentric, to the auditory guidance, presented either with monaural sound or stereo sound which corresponded to environmental headings. Spatial knowledge in Experiments 2 and 3 was assessed using route replication, novel route execution, and map construction. Contrary to the hypotheses, the aids did not improve all measures of environmental knowledge. Instead, there was a match between the particular reference frame reinforced by the aid and the relevant frame of reference for the measure of spatial knowledge. In Experiment 2, the visual aids improved accuracy for replicating routes, p = . 01, d = . 75, this measure is egocentric. In Experiment 3, the stereo and monaural cardinal directions improved accuracy for executing a novel route, a directional measure of survey knowledge, ps < . 06, ds > . 52, which is egocentric and exocentric.
Converting LPG Stoves To Use Biomethane

This article presents a study on using portable biomethane for domestic cooking in Thailand in domestic stoves. Thailand presently uses approximately 20,000 tonnes of LPG every day. It is estimated that Thailand has the potential to produce the equivalent of 3,000 tonnes of LPG equivalent energy from compressed biomethane gas (CBG) per day. This assumes full conversion of all agricultural, industrial and mu-nicipal wastes into CBG. Since CBG is a form of renewable energy, the use of it for domestic cooking purposes will help to reduce Thailand’s dependence on imported energy and have a positive impact on the en-vironment. The difficulty arises when a cylinder of biomethane, which is processed biogas comprising of at least 85% methane, is used instead of LPG, which is comprised of propane and butane, in a cooking stove. The Wobbe index for LPG is approximately double that of biomethane indicating that they are not interchangeable gases. The density of LPG is also 2 - 3 times that of biomethane which results in incompatible calorific or heating values and flow rates, assuming constant pressure, in domestic stoves. Without modification to the stove or the supply conditions the biomethane will not properly combust. Two domestic stoves types were selected and modified to allow biomethane to be used. An experiment was setup to measure the fuel flow rates, pressure and combustion efficiency in these modified stoves. The results of these experiments point to an optimal design modifications for converting an LPG to a biomethane stove.
Difference between Location of Soil with Risk of Contamination of Soil-transmitted Helmints Eggs and Larvae (Observational Study of Coffee Plantation Area in Silo District, Jember Regency)

Soil-transmitted Helminths (STH) is a group of worms whose life cycle through the soil. The species of STH are roundworm (Ascaris lumbricoides), whipworm (Trichuris trichiura), hookworms (Necator americanus and Ancylostoma duodenale), and Strongyloides stercoralis. STH causes helminthiasis that infects more than 1.5 billion people or 24% of the world's population. Jember has many plantation areas. One of the plantations in Jember is Garahan Kidul plantation located in Sidomulyo village, Silo Sub-district, Jember. Soil on plantations tends to be moist and loose. This condition is ideal for the development of STH eggs and larvae. The general purpose of this study was to differentiate the numbers of soil contamination by STH eggs and larvae in soil samples in the garden area, riverside, and worker housing taken in the coffee plantation area in Silo District, Jember. This type of research is observational analytic with cross sectional research design. Soil samples are taken in the garden area, riverside, and worker housing that has a loose or not hard and moist soil texture. The results of the observation found that there were 4 eggs of Ascaris lumbricoides, 6 eggs and larvae of hookworm, and 2 eggs and larvae of Strongyloides stercoralis. There is the same amount of soil contamination at the location of the garden and riverside, which are 2 positive samples or 5.71% with a density of 0.02 eggs and larvae / gram of soil, while the number of soil contamination at the workers housing location is 8 positive samples or 25.71 % with a density of 0.11 eggs and larvae / gram of soil. Data were analyzed using Fisher's test. The results of data analysis showed a value of p = 0.0693 (p> 0.05) so that there were no differences in the number of soil contamination by STH eggs and larvae in the garden and river bank locations and p = 0.042 (p <0.05) so that there were differences the number of soil contamination by STH eggs and larvae at the location of worker housing with the location of garden and riverside. Keywords: STH, garden, riverside, wooker housing
Multi-Drug Resistant, Extended Spectrum beta-Lactamase and Carbapenemase Producing Bacterial Isolates among Septicemia Suspected under Five Children in Tikur Anbesa Specialized Hospital, Addis Ababa Ethiopia: Cross-sectional study

Background: Bloodstream infections due to bacterial pathogens are a major cause of morbidity and mortality among pediatric patients. Emergence of drug resistance in high classes of antibiotics among the bacterial pathogens is another issue of the public health concern. Therefore this study aimed to determine Multi-drug resistant, extended spectrum β-lactamase and carbapenemase producing bacterial isolates among septicemia suspected under five Children in Tikur Anbesa Specialized Hospital, Addis Ababa Ethiopia. Methods: Across-sectional study was conducted from September 2017 to June 2018 among pediatric patients with febrile illness aged under five in Tikur Anbesa Specialized Hospital. Three hundred forty blood samples were collected and processed following standard microbiological techniques and culture was performed using BacT/Alert machine in combination with conventional method. AST of the isolates was performed by Kirby-Bauer disc diffusion method and MIC technique Result: A total of 137(40.2%) bacterial pathogens were isolated from 340 pediatric patients suspected of BSI with febrile illness. Of these isolates 54% were Gram negative bacteria. Of the isolates 43 (31.4%) Klebsiella pneumoniae and Acinitiobactor species were the most frequently isolated pathogens. Klebsiella pneumoniae isolates were 95.6% MDR, 23.7% ESBL, and 27.1% CRE in children. Conclusion: In this study, Klebsiella pneumoniae and S. aureus are common pathogens associated with BSI in pediatrics with high antimicrobial resistance. The prevalence of MDR 51.1%, CRE 30.5% and ESBL 25.4% were alarmingly high in bacterial isolates. ESBL producing organisms were common in Klebsiella species and Escherichia coli isolates. Since most of isolates exhibit multidrug resistant, invitro- susceptibility of antimicrobials is mandatory. Strengthen antimicrobial surveillance system and antimicrobial stewardship are necessary for better management of antibiotics in addition to infection prevention practice in TASH settings. Key words: Blood stream infection, BacT/Alert, multi-drug resistance, Extended spectrum beta-lactamase, Carbapenem resistance entrobacteriaciae.
Prediction of shear strength in high-strength concrete beams considering size effect

Recent research has indicated that the current American Concrete Institute (ACI) shear provisions provide nonconservative prediction for large slender beams with a low level of longitudinal reinforcement, but conservative predictions for deep beams. In the present paper, to modify these problems in the ACI shear provisions, the ultimate shear strength equation, considering size effect and arch action, is presented for computing the shear strength in high-strength concrete beams without stirrups. Three basic equations, namely those for the size reduction factor, ρ factor and arch action factor, are derived from the crack band model of fracture mechanics, analysis of previous shear equations for longitudinal reinforcement ratio and concrete strut described as a linear function in deep beams. Constants of basic equations were determined by using statistical analysis of previous shear testing data. To verify the proposed shear strength equation for each variable, about 300 experimental data were used and the .
Structured-specified robust-multivariable-controller design for practical applications using genetic algorithms

In the conventional /spl mu/-synthesis control design, the order of the controller is higher than that of the plant and it is difficult to implement. Therefore a control design based on simple elements such as PIDs and first-order systems is desirable. A synthesis technique, blended with multiobjective characteristics, for the design of structured specified /spl mu/-suboptimal controllers is presented. The design is based on a genetic-algorithm-optimisation approach and the resulting controllers ensure stability and high performance for the entire operating region. A multivariable example involving a supermanoeuverable HIMAT aircraft is used to illustrate the applicability of the design.
Multi-user downlink beamforming with multiple transmit and receive antennas

Downlink multiple-input, multiple-output (MIMO) systems assuming a large number of base station antennas, a small number of mobile station antennas, and rich-scattering, quasi-stationary, and flat-fading channel environments are considered. A MIMO space-division multiple access (SDMA) technique is proposed which enables concurrent transmission of multiple data streams to each multiple mobile station. The proposed method can achieve much higher downlink channel capacity than conventional MIMO techniques.
Tensile Tests and Failure Analysis of Concrete

The tensile strength of concrete is receiving an increasing amount of attention since the loading capacity and durability of structures are being studied more thoroughly, and since nonlinear fracture mechanics and numerical methods require a complete stress deformation relation. The theoretical background of the application of the tensile strength of concrete in fracture analysis is given. Test results are presented that were obtained from deformation‐controlled uniaxial tensile tests under static and cyclic loading of lightweight and normalweight concrete. The results have been used to establish material models for finite element calculations. Numerical examples show the usefulness of these models for static and cyclic loading conditions.
Hydrodynamic ram analysis of aircraft fuel tanks with different composite T-joint designs

Three different composite T-joint designs were investigated experimentally and numerically for application in fuel-filled wing tanks under hydrodynamic ram (HRAM) loads. The test campaigns covering 0° T-pull and 30° T-bending tests were conducted under quasi-static and high-rate dynamic conditions in order to assess potential strain rate effects on the failure behaviour. In addition to the experimental test campaign, numerical modelling with the explicit finite element code LS-Dyna was conducted with the models being validated against the test results and being applied to ballistic impact simulations of a composite fuelfilled tank structure. While the unreinforced baseline design showed a rather brittle behaviour and poor performance, significant residual strength improvements and structural integrity under HRAM loads could be obtained with a hybrid design with metallic, arrow-shaped z-reinforcements between the composite laminates of skin and spar. A promising macro modelling approach for an efficient representation of the T-joint failure behaviour in large models was derived and successfully applied to structural HRAM simulations.
Autoantibodies Detected in MIS-C Patients due to Administration of Intravenous Immunoglobulin

The autoantibody profile associated with known autoimmune diseases in patients with COVID-19 or multisystem inflammatory syndrome in children (MIS-C) remains poorly defined. Here we show that adults with COVID-19 had a moderate prevalence of autoantibodies against the lung antigen KCNRG, and SLE-associated Smith autoantigen. Children with COVID-19 rarely had autoantibodies; one of 59 children had GAD65 autoantibodies associated with acute insulin-dependent diabetes. While autoantibodies associated with SLE/Sjogren syndrome (Ro52, Ro60, and La) and/or autoimmune gastritis (gastric ATPase) were detected in 74% (40/54) of MIS-C patients, further analysis of these patients and of children with Kawasaki disease (KD), showed that the administration of intravenous immunoglobulin (IVIG) was largely responsible for detection of these autoantibodies in both groups of patients. Monitoring in vivo decay of the autoantibodies in MIS-C children showed that the IVIG-derived Ro52, Ro60, and La autoantibodies declined to undetectable levels by 45-60 days, but gastric ATPase autoantibodies declined more slowly requiring >100 days until undetectable. Together these findings demonstrate that administration of high-dose IVIG is responsible for the detection of several autoantibodies in MIS-C and KD. Further studies are needed to investigate autoantibody production in MIS-C patients, independently from IVIG administration.
Safety and immunogenicity of heterologous and homologous inactivated and adenoviral-vectored COVID-19 vaccines in healthy adults

In light of intermittent supply shortages of individual vaccines and evidence of rare but serious adverse events after vaccination, heterologous regimens for COVID-19 vaccines have gained significant interest. This study aims to assess the reactogenicity and immunogenicity of the heterologous adenoviral vector vaccine regimen (ChAdOx1-S, AstraZeneca; hereafter referred to as AZ) and the inactivated vaccine regimen (CoronaVac; hereafter referred to as CV) regimen in healthy Thai adults immunized between June and September 2021. Our study showed that adverse events following homologous CV-CV and AZ-AZ, and heterologous CV-AZ and AZ-CV combinations, were mild and well tolerated overall. Receptor-binding domain (RBD)-specific antibody responses and neutralizing activities against wild-type and variants of concern after two-dose vaccination were higher in the heterologous CV-AZ and homologous AZ-AZ groups compared to the CV-CV and AZ-CV groups. Conversely, the spike-specific IgA response was detected only in the CV-AZ group after two doses of vaccination. The total interferon gamma response was detected in both the CV-AZ and AZ-CV groups after the two-dose vaccination. Given the shorter completion time of two doses, heterologous CoronaVac followed by ChAdOx1-S can be considered as an alternative regimen to homologous efficacy-proven ChAdOx1-S in countries with circulating variants. Additional studies on the efficacy and durability of immune responses induced by heterologous vaccine regimens are warranted.
Analyzing Surgical Volumes, Rates, and Need in Rural India

Background: Globally, 5 billion people lack timely access to safe and affordable surgical care, with over a fifth of them living in India. Solving India's surgical access issues can have high returns on investment. While healthcare access and unaffordability problems are well-known in India particularly among its rural people, research on surgical volumes and need is scant. This study attempts to fill the research gap through high-resolution nationwide estimates that have direct implications for India's national surgical plan. Methods: Secondary data analysis with a diverse geospatial and statistical toolbox was used to create the national, state, and district-level estimates for surgical rates and c-section proportions and their corresponding met need w.r. t. to the globally prescribed thresholds: 5000 major surgeries (those requiring anesthesia) per 100,000 (Lancet Commission on Global Surgery) and 10-15% of all institutional deliveries (World Health Organization). Results: Nationally, only 6.81% of need for major surgical operations was met for rural India. 13.6% of the institutional deliveries were c-sections falling within the WHO-prescribed range of 10-15%. There were marked variations at state and district-levels and significant rural-urban differences for surgical rates and c-section proportions. We validate our estimates based on data from Health Management and Information System against existing sources that are commonly used in academic and policy research. Conclusions: Our methodological workflow has high translational value for global surgery research in low-and-middle-income countries. For India, these are the first such nationwide findings that can direct the development of a National Surgical, Obstetric, and Anesthesia Plan (NSOAP).
Clinical Predictors of Liver Fibrosis Presence and Progression in Human Immunodeficiency Virus–Associated Nonalcoholic Fatty Liver Disease

Background. Nonalcoholic fatty liver disease (NAFLD) affects more than one-third of people living with human immunodeficiency virus (HIV). Nonetheless, its natural history is poorly understood, including which patients are most likely to have a progres-sive disease course. Methods. We leveraged a randomized trial of the growth hormone–releasing hormone analogue tesamorelin to treat NAFLD in HIV. Sixty-one participants with HIV-associated NAFLD were randomized to tesamorelin or placebo for 12 months with serial biopsies. Results. In all participants with baseline biopsies (n = 58), 43% had hepatic fibrosis. Individuals with fibrosis had higher NAFLD Activity Score (NAS) (mean ± standard deviation [SD], 3.6 ± 2.0 vs 2.0 ± 0.8; P < .0001) and visceral fat content (mean ± SD, 284 ± 91 cm 2 vs 212 ± 95 cm 2 ; P = .005), but no difference in hepatic fat or body mass index. Among placebo-treated participants with paired biopsies (n = 24), 38% had hepatic fibrosis progression over 12 months. For each 25 cm 2 higher visceral fat at baseline, odds of fibrosis progression increased by 37% (odds ratio, 1.37 [95% confidence interval, 1.03–2.07]). There was no difference in baseline NAS between fibrosis progressors and nonprogressors, though NAS rose over time in the progressor group (mean ± SD, 1.1 ± 0.8 vs −0.5 ± 0.6; P < .0001). Conclusions. In this longitudinal study of HIV-associated NAFLD, high rates of hepatic fibrosis and progression were observed. Visceral adiposity was identified as a novel predictor of worsening fibrosis. In contrast, baseline histologic characteristics did not relate to fibrosis progression.
Reappraising Treatment Effect Heterogeneity in Schizophrenia: A Meta-analysis

Objective Determining whether individual patients differ in response to treatment ('treatment effect heterogeneity') is important as it is a prerequisite to developing personalised treatment approaches. Previous variability meta-analyses of response to antipsychotics in schizophrenia found no evidence for treatment effect heterogeneity. Conversely, individual patient data meta-analyses suggest treatment effect heterogeneity does exist. In the current paper we combine individual patient data with study level data to resolve this apparent contradiction and quantitively characterise antipsychotic treatment effect heterogeneity in schizophrenia. Method Individual patient data (IPD) was obtained from the Yale University Open Data Access (YODA) project. Clinical trials were identified in EMBASE, PsycInfo, and PubMed. Treatment effect heterogeneity was estimated from variability ratios derived from study-level data from 66 RCTs of antipsychotics in schizophrenia (N=17,202). This estimation required a correlation coefficient between placebo response and treatment effects to be estimated. We estimated this from both study level estimates of the 66 trials, and individual patient data (N=560). Results Both individual patient (r=-0.32, p=0.002) and study level (r=-0.38, p<0.001) analyses yielded a negative correlation between placebo response and treatment effect. Using these estimates we found evidence of clinically significant treatment effect heterogeneity for total symptoms (our most conservative estimate was SD = 13.5 Positive and Negative Syndrome Scale (PANSS) points). Mean treatment effects were 8.6 points which, given the estimated SD, suggests the top quartile of patients experienced beneficial treatment effects of at least 17.7 PANSS points, while the bottom quartile received no benefit as compared to placebo. Conclusions We found evidence of clinically meaningful treatment effect heterogeneity for antipsychotic treatment of schizophrenia. This suggests efforts to personalise treatment have potential for success, and demonstrates that variability meta-analyses of RCTs need to account for relationships between placebo response and treatment effects.