Miracle-dz/UniFAR-FTUs huggingface dataset:
Injection-Type GaInAsP/InP Membrane Buried Heterostructure Distributed Feedback Laser with Wirelike Active Regions

A current-injection-type semiconductor membrane distributed feedback laser consisting of a 470-nm-thick semiconductor core and bonded by a benzocyclobutene polymer on a silicon-on-insulator substrate was demonstrated for the first time by adopting a lateral current-injection structure. Room-temperature pulsed operation was achieved with a threshold current of 83 mA for a stripe width of 3.2 µm and cavity length of 420 µm.
Parametric Evaluation of Microwave–Assisted Extraction of Phenolics from C. domestica Val.

Conventional methods for the extraction of natural products from plant are characterised by the consumption of large volumes of solvent, energy, lengthy extraction procedures and the potentially deleterious degradation of labile compounds. In the last two decades there has been an increasing demand for new extraction techniques, amenable to automation, with shortened extraction times, reduced organic solvent consumption, prevention pollution in analytical laboratories and reducing sample preparation costs. Unmodified domestic microwave oven is used in the extraction of phenolics from C. domestica Val. using water as solvent. The Microwave Assisted Extraction produced a better yield of crude extract of 48 mg compared to Soxhlet extraction methods with only an extraction yield 3.4 mg. Effects of extraction time, microwave power and solvent volume are evaluated on the extraction of phenolic compounds.
Deciphering S-RNase Allele Patterns in Cultivated and Wild Accessions of Italian Pear Germplasm

The genus Pyrus is characterized by an S-RNase-based gametophytic self-incompatibility (GSI) system, a mechanism that promotes outbreeding and prevents self-fertilization. While the S-genotype of the most widely known pear cultivars was already described, little is known on the S-allele variability within local accessions. The study was conducted on 86 accessions encompassing most of the local Sicilian varieties selected for their traits of agronomic interest and complemented with some accessions of related wild species (P. pyrifolia Nakai, P. amygdaliformis Vill.) and some national and international cultivars used as references. The employment of consensus and specific primers enabled the detection of 24 S-alleles combined in 48 S-genotypes. Results shed light on the distribution of the S-alleles among accessions, with wild species and international cultivars characterized by a high diversity and local accessions showing a more heterogeneous distribution of the S-alleles, likely reflecting a more complex history of hybridization. The S-allele distribution was largely in agreement with the genetic structure of the studied collection. In particular, the “wild” genetic background was often characterized by the same S-alleles detected in P. pyrifolia and P. amygdaliformis. The analysis of the S-allele distribution provided novel insight into the contribution of the wild and international cultivars to the genetic background of the local Sicilian or national accessions. Furthermore, these results provide information that can be readily employed by breeders for the set-up of novel mating schemes.
The serological response to SARS corona virus-2 is characterized by frequent incomplete maturation of functional affinity (avidity)

The humoral immune systems controls viral infections through recognition of critical viral target structures, selective proliferation stimulation of IgM-presenting B cells, class switch to IgG-generating B cells and subsequent affinity maturation of IgG. Affinity maturation is achieved through proliferation, hypermutation and clonal selection of IgG-generating B cells (1-4). The establishment of high affinity IgG is essential for sustained protective antiviral effects (5-10). While analyzing the maturation of functional affinity (avidity) of IgG towards SARS CoV-2 nucleoprotein, surface protein and its receptor-binding domain, we realized that avidity maturation was frequently not completed after infection. This finding gives insight into the biological strategy of SARS CoV-2 and is important for serodiagnosis. Incomplete avidity maturation might explain the observed decline of the humoral response (11-14), allow for secondary SARS CoV-2 infections and prevent the establishment of herd immunity. Therefore, future immunization strategies should achieve the goal to induce neutralizing IgG of high avidity.
A case report of somatic symptom disorder as first manifestation of semantic dementia

Semantic dementia (SD) is a progressive neurodegenerative disorder in which patients present a loss of meaning of words, objects, and concepts. SD has been linked with alexisomia, as well as somatic symptom disorder (SSD). A 65 year-old patient with a 2-year history of daily episodes of pulsatile head and chest sensations followed by prostration with maintained awareness was diagnosed with SSD. The patient was subsequently admitted into an epilepsy unit to exclude the diagnosis of epileptic seizures. Clinical, neuropsychological, and neuroimaging assessments were consistent with the diagnosis of probable SD. This case report presents a patient whose first manifestation of SD was SSD, thus highlighting the importance of both careful clinical and neurocognitive enquiry, and caution in diagnosing SSD in later life. This case outlines the association between SD and somatic symptoms, providing insight into the nature of alexisomia and the emergence of SSD in SD.
Reliable Determination of Electron Diffusion Length and Charge Separation Efficiency in Dye-Sensitized Solar Cells

Reliable quantification of parameters influencing the efficiency of dye-sensitized solar cells (DSCs) is essential to guide device optimization and improve the fundamental understanding of device operation. The small-perturbation electron diffusion length (Ln) in DSCs has been determined by electrochemical impedance spectroscopy and by analysis of incident photon-to-collected-electron conversion efficiency (IPCE) spectra. When measurement conditions are chosen so that recombination can be treated as first-order in the free electron concentration, Ln values obtained by the two quite different techniques are found to be in good agreement. This result provides an important experimental validation of the simple diffusion−recombination model that is commonly used to explain DSC operation. Knowledge of Ln facilitates deconvolution of the charge separation efficiency (ηsep) from IPCE. ηsep is found to decrease significantly with increasing VOC for all DSCs studied here. This phenomenon is likely to be caused by .
Metal Schottky barrier contacts to alpha 6H:SiC

Formation of Schottky barrier contacts to n‐type 6H‐SiC for a number of metals chosen to include a variety of physical and chemical properties has been investigated. The metals (Pd, Au, Ag, Tb, Er, Mn, Al, and Mg) were deposited onto room temperature surfaces terminated with a submonolayer coverage of oxygen. The metal/6H‐SiC interface chemistry and Schottky barrier height φB during contact formation were obtained with x‐ray photoemission spectroscopy; the electrical properties of subsequently formed thick contacts were characterized by current‐voltage and capacitance‐voltage techniques. The o/B values for these metals extend over a wide 1.3 eV range. To a varying degree φB depends on the 6H‐SiC crystal face (Si vs C). Mg and Al (Si face of latter) have φB=0.3 eV, a value which is suitable for nonalloyed ohmic contacts.
The conditions for learning musical interpretation in one-to-one piano tuition in higher music education

Research has indicated that one-to-one teaching in higher music education in Western classical music typically favours technical over interpretive aspects of musicianship, and imitation of the teacher’s rather than the student’s explorative interpretation. The aim of the present study is to investigate students’ and teachers’ understandings of how musical interpretation of Western classical music is learned in this context. Semi-structured qualitative interviews with six piano students and four teachers in Sweden were conducted and hermeneutically analysed using haiku poems and poetical condensations. The analysis found that the conditions for learning musical interpretation centred upon students achieving a high level of autonomy, as affected by three key aspects of teaching and learning: (1) the student’s and the teacher’s understandings of what musical interpretation is, (2) the student’s experience of freedom of interpretation as acknowledged by the teacher, and (3) (expectations of) the student’s explorative approach. As none of these aspects were reported as being explicitly addressed during lessons, there might be a need for both teachers and students to verbalise them more clearly to support piano students’ development.
Evaluating Efficacy of Fumagilin-B® Against Nosemosis and Tracking Seasonal Trends of Nosema spp. in Nova Scotia Honey Bee Colonies

Abstract The efficacy of the antimicrobial Fumagilin-B® against nosemosis was evaluated in both spring and autumn feeding treatments following label directions in seventy-two honey bee (Apis mellifera) colonies across three apiaries in Nova Scotia, Canada. The seasonal trend of Nosema spp. spore loads was also tracked in these same colonies throughout a thirteen-month period (February 2018 – March 2019). We found the spring Fumagilin-B® treatment to be effective at significantly suppressing Nosema spp. spore levels below the recommended treatment threshold. There was no effect of Fumagilin-B® treatment in the autumn based on low spore levels at this time. We detected a drastic increase in Nosema spp. spore loads as May progressed but a decline in spores in summer (June–September). By October, there was another increase in spore levels, but this increase did not exceed the economic treatment threshold. Across seventeen collection periods in both control and Fumagilin-B® colonies, 74% (25) of samples tested positive for Nosema ceranae, while 26% (9) contained no Nosema spp. spores. No Nosema apis spores were detected during this trial. Our results indicate that Fumagilin-B® is an effective management practice in the spring, but colonies should still be monitored in the autumn. Our data also support that the Nosema species profile is shifting to be exclusively N. ceranae and the treatment threshold for Fumagilin-B® may need to be updated to reflect this, as the threshold was originally developed for N. apis.
CAREER ADAPTABILITY MEDIATING THE EFFECT OF SELF-EFFICACY ON ENTREPRENEURIAL INTENTION

Entrepreneurial intention is a possibility for someone to create something new by using some available resources and opportunities that exist without ignoring the risks faced. The research objective is to analyze the mediating role of career adaptability on the effect of self-efficacy on entrepreneurial intentions. The research was conducted at the Faculty of Economics and Business, University of Udayana, by taking a sample of 136 respondents from the Faculty of Economics and Business majoring in Management. The data of this study was collected by distributing a number of questionnaires. The collected data was analyzed by using path analysis technique. The results of the analysis show that self-efficacy has a positive and significant effect on entrepreneurial intentions. Furthermore, self-efficacy has a positive and significant effect on career adaptability. Career adaptability has a positive and significant effect on purchase intention. Career adaptability significantly mediates the relationship between self-efficacy and entrepreneurial intention.
RNAi inhibition of angiopoietin-like protein 3 (ANGPTL3) with ARO-ANG3 mimics the lipid and lipoprotein profile of familial combined hypolipidemia

Elevated LDL-C and triglyceride rich lipoproteins (TRLs) are independent risk factors for cardiovascular disease (CVD). Genetic deficiency of angiopoietin-like protein 3 (ANGPTL3) is associated with reduced circulating levels of LDL-C, triglycerides (TGs), VLDL-C, HDL-C and reduced CVD risk, with no described adverse phenotype. ARO-ANG3 is a RNA interference drug designed to silence expression of ANGPTL3. Single doses of ARO-ANG3 have been shown to reduce ANGPTL3, TGs, VLDL-C and LDL-C in healthy volunteers (HVs, AHA 2019). We report the effects of multiple doses of ARO-ANG3 in HVs with a focus on the duration of action. ARO-ANG3 was administered subcutaneously to HVs on days 1 and 29 at doses of 100, 200 or 300 mg (n=4 per group). Measured parameters included ANGPTL3, LDL-C, TGs, VLDL-C and HDL-C. Follow up is ongoing. All HVs have received both doses and follow-up is currently through week 16 (12 weeks after second dose). Mean nadir for ANGPTL3 levels occurred 2 weeks after the second dose (−83–93%) with minimal change for 200 and 300 mg but 16% recovery for 100 mg at week 16. Mean TGs and VLDL-C reached nadir earlier (3 wks, −61–65%) without apparent dose response and minimal change for any dose at wk 16. LDL-C nadir occurred 4–6 wks after the second dose (−45–54%), again with minimal evidence for dose response or change through wk 16. HDL-C was reduced 14–37% at wk 16. ARO-ANG3 was well tolerated without serious or severe adverse events or dropouts related to drug. The most common adverse events have been headache and upper respiratory infections. Genetic deficiency of ANGPTL3 is a cause of familial combined hypolipemia and is associated with a decreased risk of CVD. Using RNAi to selectively suppress ANGPTL3 production reproduces these genetic effects with a duration of at least 12 weeks following a second dose and with good tolerability over 16 wks. ANGPTL3 inhibition results in lowering of LDL-C and TRLs which may confer protection against CVD in patients with atherogenic mixed dyslipidemia. Type of funding source: Private company. Main funding source(s): Arrowhead Pharmaceuticals
Os estudantes leem as mensagens de feedback estendido exibidas em juízes online?

Apesar dos benefícios dos juízes online em relação ao processo de correção automática de códigos, a literatura afirma que o feedback desses sistemas precisa ser aprimorado para gerar um aprendizado mais efetivo para o estudante. Este artigo aprofunda um estudo anterior, do tipo intervenção-controle, e visa identificar se o feedback apresentado aos alunos de programação introdutória foi visualizado, e se houve diferença estatisticamente significante entre o interesse dos diferentes grupos pelo conteúdo do feedback. Foi observada diferença entre os alunos dos grupos teste e controle em relação ao tempo de leitura, tempo de leitura por palavra, ocorrências de alguns tipos de erro e em relação à frequência de acesso ao feedback.
Global FDI Inflow and Its Implication across Economic Income Groups

Foreign direct investment (FDI) as a driver of growth is important in today’s globalized economy. It is extremely difficult for economies to grow sustainably without economic interactions outside their borders. However, there has been a debate on the impact of FDI inflow on economic expansion. Hence, this study investigated the influence of FDI on economic growth for a selection of 200 economies around the world for the period 1990–2018. We subdivided the sample into World Bank income group clusters to aid comparison across income blocs. The study employed panel estimation techniques including pooled ordinary least squares (POLS), dynamic panel estimation with fixed-effects and random-effects and generalized method of moments (GMM). The study found that FDI, debt stock and official development assistance are promoters of growth in the selected countries—although debt stock weakly impacts economic growth. In contrast, trade openness and exchange rates had a mixed (negative and positive) influence on economic growth. The study suggests that the creation of a conducive business environment and economic policies will attract FDI inflows. Additionally, borrowing from external sources could be minimized despite its perceived positive influence on growth to achieve financial independence.
Simple, Three-Component, Highly Efficient Green Synthesis of Thiazolo[3,2-a]pyridine Derivatives Under Neat Conditions

Abstract Green, highly efficient, three-component syntheses of thiazolo-[3,2-a]pyridine derivatives via reaction of malononitrile, aromatic aldehydes, and 2-mercaptoacetic acid with a catalytic amount of piperidine without solvent with molar ratios of 2:2:1.2 and 2:2.2:1, respectively, has been reported.
Are emotionally intelligent people happier? A meta‐analysis of the relationship between emotional intelligence and subjective well‐being using Chinese samples

To assess an overall correlation between emotional intelligence (EI) and subjective well-being (SWB) within Chinese culture, accounting for possible moderating factors, we conducted a meta-analysis of 119 correlations obtained from 62 studies with a total sample size of 29,922. The results uncovered a moderately positive correlation, r = . 32, 95% CI [0.29, 0.36], p < . 001, between EI and SWB. The strength of the correlation was moderated by EI stream, SWB component, participant’s age, and participant’s employment status. Specifically, this association was stronger when EI was measured as self-report mixed EI, r = . 49, and self-report ability EI, r = . 32, than when it was measured as performance-based ability EI, r = . 08. In addition, EI was more strongly associated with the cognitive components of SWB, r = . 32, than with the affective component of SWB, r = . 29, and the EI–SWB association was stronger in adults, r = . 33, than in adolescents, r = . 25. Furthermore, EI was more closely related to SWB in working adults, r = . 43, compared to students, r = . 29, and EI was almost equally associated with SWB across males and females, b = . 08, p = . 55. The results, as well as their theoretical and practical implications, are discussed in detail with reference to relevant cross-cultural theories and comparative empirical findings.
Recommended parameters for hepatocyte isolation-a review

There is an increasing demand for primary human hepatocytes for toxico-pharmacological studies and for exploring their role in liver cell transplantation. During the whole process of isolation, culture and cryopreservation hepatocytes are subjected to various stress. All these factors will lead to the impairment in the metabolic capability of the hepatocytes post isolation. Hepatocyte isolation is an expensive and resource driven procedure. Thus, it is important to consider all the factors before we subject the specimen for isolation of cells. By considering the factors that influence hepatocyte isolation, hepatocytes of good quality can be obtained. With recommendations on the ideal parameters for isolation being made the researcher shall have a knowledge on what critical factors need to be taken care of during hepatocyte isolation. There will be an opportunity to modify critical factors if possible, during the procurement of specimen by working in tandem with the clinicians. The specimen which shall be deemed un fit when two or more factors have exceeded the critical limits can be rejected.
Detecting the net effect of flooding on infectious diarrheal disease in Anhui Province, China: a quasi-experimental study

Though a number of studies have shown positive relationships between flooding events and infectious diarrhea, there is a paucity of rigorous evidence regarding the net effect of flooding on diarrhea incidence, controlling for existing pre-trends and meteorological confounders. The study treats the 2016 catastrophic flood event in Anhui Province, China as a natural experiment using a difference-in-differences design with propensity score matching to exclude background variations of diarrhea occurrence and meteorological effects, thus isolating the net effect of flooding on diarrhea. A triple-differences analysis was further deployed to identify the potential effect modifiers, including gender, age, occupation and community health resources. By analyzing 359 580 cases of diarrhea that occurred before, during and after the flooding, we show that the 2016 flood event significantly increased the risk of dysentery (RR: 1.29, 95%CI: 1.15–1.46) in during-flood period, and also increased the risk of all-cause diarrhea (RR: 1.21, 95%CI: 1.17–1.26), typhoidal diarrhea, dysentery, and other infectious diarrhea in post-flood period. Children, males and non-farmers were particularly vulnerable to flooding impacts and the density of health professionals was found to be protective against diarrheal risk in both during-flood (RR: 0.81, 95% CI: 0.72–0.92) and post-flood (RR: 0.83, 95% CI: 0.77–0.88) periods. This study employs quasi-experimental design and provides a better understanding on both acute and sustained effects of flooding on diarrhea, which is important for accurate health impact assessments and developing targeted intervention strategies.
Are there gender differences in access to and demand for East Coast fever vaccine? Empirical evidence from rural smallholder dairy farmers in Kenya

Women lag in the adoption of agricultural innovations compared to men, mainly due to gender inequalities in access to complementary inputs, capital, and knowledge/information. The Infection-and-Treatment-Method (ITM) is considered a safe and effective method of controlling East Coast fever. However, since its commercialisation in Kenya differences in demand for this vaccine among smallholder men and women dairy cattle keepers have not been assessed. Using a sample of 448 respondents, we used an Average-Treatment-Effect framework to estimate ITM adoption rates under awareness constraints and the determinants of adoption among smallholder male-headed (MHHs) and femaleheaded (FHHs) households. We found some difference in ITM awareness between MHHs (57 per cent) and FHHs (46 per cent). However, gender adoption gaps in the actual and potential adoption rates were considerable, with actual adoption rates of 41 per cent and potential adoption rate of 62 per cent among MHHs, compared to 19 per cent actual and 31 per cent potential adoption for FHHs. The smaller adoption gap for FHHs indicates that only increasing awareness amongst FHHs will not reduce inequities. ITM adoption in both household headships was mainly determined by education, extension interventions, access to financial services, and social capital. In addition to this, ITM adoption in FHHs was positively influenced by age, land-size, and group membership. To realise adoption beyond the current potential and to reduce inequities at the scale-up stage, gender-specific interventions targeting resource-poor women cattle keepers would be effective, in addition to ensuring that women have access to extension and financial services.