Miracle-dz/UniFAR-FTUs huggingface dataset:
Assessment of the ability of dietary yeast-fermented rapeseed
meal to modulate inflammatory and oxidative stress
in piglets after weaning

The ban on the use of antibiotics in feed (EC, 2006) has had a significant impact on the livestock sector, especially for pigs after weaning (Taranu et al., 2015). Consequently, it is necessary to find new sources of antimicrobial compounds, which has opened up many opportunities for animal nutrition research. The processing of plants (oilseeds, cereals, medicinal plants, etc.) for feed or food, or non-food products (e.g. oil, alcohol, kerosene, etc.) generates a wide range of by-products with significant ABSTRACT. The aim of the study was to investigate the potential of a diet containing rapeseed meal fermented by Saccharomyces cerevisiae as a new sustainable feed to reduce transient intestinal inflammation, diarrhoea and oxidative stress in piglets after weaning. In this study, 16 male post-weaning piglets, with an initial weight of 9.04 ± 0.19 kg, were randomly allocated to two dietary treatments: control and 10% fermented rapeseed meal (FRSM) – 8 pigs/treatment. The experiment lasted 21 days. At the end of the trial, the animals were slaughtered and samples of blood and segments of the jejunum, ileum and colon were collected for determination of plasma biochemical, inflammatory and oxidative stress parameters. Pig performance and diarrhoea incidence were also investigated. The results showed that the FRSM diet had no significant effect on piglet performance, weight and average daily weight gain, as well as plasma biochemical parameters. However, the number of piglets with diarrhoea was higher in the control group than in the group receiving the FRSM diet throughout the experimental period. Moreover, a decrease in TNF-α (P = 0.03) and IL-1ß (P < 0.05) cytokine levels was recorded in the colon and jejunum samples from the FRSM group. In addition, IL-8 and IL-6 concentrations were decreased (P = 0.0009 and P = 0.03, respectively) in the ileum of piglets fed FRSM, indicating the modulatory capacity of this feed in reducing weaning-associated intestinal inflammation. The FRSM diet also improved the antioxidant status and significantly reduced lipid peroxidation and thiobarbituric acid reactive substance levels in plasma (P = 0.022) and in the jejunum (P = 0.028) and colon (P = 0.003), suggesting the potential of fermented rapeseed meal to limit oxidative reactions. In conclusion, the present study showed that fermentation of rapeseed meal using S. cerevisiae enriched the nutrient composition and reduced the concentration of anti-nutrients (e.g. glucosinolates). Moreover, the addition of FRSM to diets of pigs after weaning improved their intestinal health status, indicating its beneficial effect. Received: 14 January 2022 Revised: 7 March 2022 Accepted: 5 April 2022
Uncovering a Failed Pediatric Patient Population in Rural America: A Statewide Analysis of Over 1,000 Dog Bite Injuries

Pediatric dog bites are prevalent and often devastating. Population-based data on these injuries can aid public health intervention efforts. However, most existing literature comes from single institutions in urban settings. We assess a statewide cohort to compare injury characteristics in urban and rural regions and find predictors for inter-hospital transfer. Data from 1,007 injuries from 2000 to 2015 were analyzed. Patients in rural areas were younger, more likely to be white and low-income, and more likely to receive delayed patient care. Injuries occurring in public settings as opposed to the private residence were more likely to involve males, occur in low-income areas, and involve non-white patients. Patients who required inter-hospital transfer were more likely to require a surgical subspecialist and operative repair. Our population analysis reveals children living in rural areas as a previously unidentified vulnerable patient population that may be suitable targets for public health interventions.
Effects of geometry and loading on the elastic behavior of a single osteon via analytical structural mechanics approaches

In this study, two analytical approaches for lamella texture at micro-scale including disordered mineralized and organized collagen fibers are employed to provide analytical models of an osteon. A two-step homogenization procedure is also applied to characterize the elastic properties of the osteon. Numerical evaluations are accomplished to explore the effects of loading and geometrical parameters on the behavior of the osteon. Results show the diameter of the Haversian canal is the dominant geometrical parameter influencing the elastic stresses in the osteon. The radial and hoop stresses as well as radial displacement are insensitive to the changes in the number of lamellae. The ordered motif osteon model can also be used to explain circumferential micro-cracks along lamellae leading to irregular profiles of fracture in osteon direct tensile tests. The theoretical model of osteon based on the lamination theory generally indicated better agreement with existing experimental results.
Enabling industrial internet of things-based digital servitization in smart production logistics

ABSTRACT Digital servitization (DS) enabled by the Industrial Internet of Things (IIoT) is essential for securing long-term competitiveness in manufacturing. The literature identifies the need for developing data models for multichannel communications across IIoT devices that fulfil the DS vision. This is crucial for avoiding isolated systems based on proprietary solutions and for promoting data sharing and interoperability across existing and future DS applications. Accordingly, this study proposes a data model for multichannel communication that facilitates IIoT-enabled DS for smart production logistics (SPL). We present three findings from a case study focussing on material handling in a manufacturing company. First, this study provides a model with four modelling profiles, including IIoT devices, databases, and services for multichannel communication. Second, it shows how the proposed modelling profiles transfer information across monitoring, control, optimisation, and autonomous decision services. Third, it presents the operational benefits of applying the proposed data models, including improvements in the delivery, makespan, and energy of material handling. These findings are essential for capturing, processing, and transferring information across products, services, and software databases in IIoT-enabled DS for SPL. They are relevant for manufacturing managers and academics and improve our understanding of IIoT-enabled DS's deployment for SPL in manufacturing.
Antiquity in the history of music: A critical review of the music textbooks for secondary education in Spain

The history of music is shaped through narratives that sometimes contain a number of issues regarding cultural stereotypes, historiographic approaches, Eurocentrism or colonialism. For this reason, its transmission and the way it is taught must be the object of study and careful consideration. The present research analyses – on the basis of narratological and organological premises – the contents that shape the discourses underlying the coverage of the ancient period by music education textbooks used in the Spanish compulsory secondary education stage. To this effect, an ad hoc instrument was designed and implemented on 24 coursebooks. The results confirmed that the chronological narrative is the most widely used strategy and that in more than half of the textbooks under examination the history of music begins to be told after Antiquity. Other findings were that the construct of the ‘foundational’ civilisations of the West is still perpetuated and that an organological narrative is proposed which is inspired by a diffusionist approach. In conclusion, we detect patterns that are controversial and need to be subjected to revision at a time when educational textbooks are a decisive resource that adapts the official curriculum and mediates between the latter and music education teachers.
Tracing the spatial‐temporal evolution dynamics of air traffic systems using graph theories

Air traffic systems are of great significance to our society. However, air traffic systems are extremely complicated since an air traffic system encompasses many components which could evolve over time. It is therefore challenging to analyze the evolution dynamics of air traffic systems. In this paper we propose a graph perspective to trace the spatial‐temporal evolutions of air traffic systems. Different to existing studies which are model‐driven and only focus on certain properties of an air traffic system, in this paper we propose a data‐driven perspective and analyze a couple of properties of an air traffic system. Specifically, we model air traffic systems with both unweighted and weighted graphs with respect to real‐world traffic data. We then analyze the evolution dynamics of the constructed graphs in terms of nodal degrees, degree distributions, traffic delays, causality between graph structures and traffic delays, and system resilience under airport failures. To validate the effectiveness of the proposed approach, a case study on the American air traffic systems with respect to 12‐month traffic data is carried out. It is found that the structures and traffic mobilities of the American air traffic systems do not evolve significantly over time, which leads to the stable distributions of the traffic delays as evidenced by a causality analysis. It is further found that the American air traffic systems are quite robust to random airport failures while, respectively, 20% and 10% failures of the hub airports will lead to the collapse of the entire system with respect to the two proposed cascading failure models.
Situational dynamic implementation intentions of mobile shopping behaviour: Based on the perspective of dual contextual cues

ABSTRACT Contextual cues can stimulate consumers’ memory, increase their attention, and promote their purchase behaviour. Nevertheless, the dynamic mechanism of online shopping behaviour implementation intention in intricate social contexts has not been investigated comprehensively. Based on the theory of implementation intention, this study constructs a research framework from the standpoint of dual contextual cues of businesses and consumers, designs corresponding models by using system dynamics method, and validates its efficacy and sensitivity to elucidate the dynamic implementation intention mechanism of consumers’ social shopping behaviour. The purchase implementation intention of consumers is influenced by not only their psychological changes but also businesses, showing a fluctuating upward trend over time. Consumers’ implementation intention is highly sensitive to quality and safety cues and prospective memory of businesses degree. This study expands the viewpoint of contextual cues theory from the perspective of duality, upgrades the systematic mechanism of contextual cues and implementation intention, and finally offers relevant suggestions for businesses to promote consumer purchase behaviour.
Accumulation of Deleterious Effects in Gastric Epithelial Cells and Vascular Endothelial Cells In Vitro in the Milieu of Helicobacter pylori Components, 7-Ketocholesterol and Acetylsalicylic Acid

The Gastric pathogen Helicobacter pylori (HP) may influence the development of coronary heart disease (CHD). H. pylori induce reactive oxygen species (ROS), which transform cholesterol to 7-ketocholesterol (7-kCh), a CHD risk factor. Acetylsalicylic acid (ASA)—an Anti-aggregation drug used in CHD patients—may increase gastric bleeding and inflammation. We examined whether H. pylori driven ROS effects in the cell cultures of gastric epithelial cells (AGS) and vascular endothelial cells (HUVEC) progress in the milieu of 7-kCh and ASA. Cell cultures, exposed to 7-kCh or ASA alone or pulsed with the H. pylori antigenic complex—Glycine acid extract (GE), urease (UreA), cytotoxin associated gene A (CagA) protein or lipopolysaccharide (LPS), alone or with 7-kCh and ASA—were examined for ROS, apoptosis, cell integrity, interleukin (IL)-8, the activation of signal transducer, the activator of transcription 3 (STAT3), and wound healing. ASA and 7-kCh alone, and particularly in conjunction with H. pylori components, increased the ROS level and the rate of apoptosis, which was followed by cell disintegration, the activation of STAT3, and IL-8 elevation. AGS cells were unable to undergo wound healing. The cell ROS response to H. pylori components may be elevated by 7-kCh and ASA.
Re-envisioning a future in scholarly communication

Scholarly communication is in need of disruption. Commodifying knowledge as is currently done with journals, is not sustainable any longer. An alternative is the commodification of how information is consumed. By focusing on the commodification of consumption instead of commodification of the resource, the problem of access to knowledge can be resolved in a sustainable manner. Additionally, commodification of consumption removes several perverse incentives from the scholarly system that now produce unreliable knowledge. The main tenet underlying the themes of Open Access, Open Data, Open Science, and replication initiatives in scholarly communication is sustainability through transparency of the scholarly process in all facets. The sustainability of any networked system is threatened by single points of failure (i.e., the entire system can be manipulated from one node in the network). The scholarly process is ridden with such single points of failures at all stages. Distributing the scholarly communications system would remove the problems of single points of failure. Distributing and decentralizing the scholarly communications system is achievable with newly developed peer-to-peer (p2p) Internet protocols. Alongside decentralization and distribution of the content, integrity of the scholarly record can also be reformed to transform sections of a paper into different, reusable nodes of knowledge. These nodes can be logged on a blockchain based ledger of which everyone can have a copy. In order to deposit nodes onto the ledger, the depositor needs to agree that the contents are licensed CC 0, in order to maximize legal certainty regarding reuse of the contents. This is key to create a sustainable eco-system where scholars and companies can cooperate instead of compete, as we currently do.
Peculiarities of German World Economic Development Policy

The growth rates and sustainability of the economic development of German-speaking countries in the years 1850-2020 have been investigated. The comparison is made for 18 economic cycles, which are grouped into 4 historical periods: imperial, republican-fascist, division and unity. The proposed method for economic development policies to be studied makes it possible to quantify the proximity of economic development strategies based on the changes in economic growth and risk. The features of progressive, regressive, conservative and aggressive policies of economic development are described. The formula for evaluating the index of similarity of economic development policy is proposed. In accordance with this indicator, a comparison of the economic policy of Germany with more than 30 European countries showed that the similarity of policies depends on the influence of the cultures and institutions of the compared countries on the strategy of their economic development. In the current historical period, 3 cultural and geographical groups of countries have been identified with a policy of economic development that coincides with Germany, with an independent and opposite policy. The results of the research show the area of the German world as a subcivilizational community.
Research progress of signaling pathways of the natural substances intervene dyslipidemia (Review)

Dyslipidemia is an umbrella term for a range of lipid metabolic disorders in the body. This condition has been widely reported to greatly increase the risk of cardiovascular diseases, threatening human health. In recent years, advances in molecular biology have deepened understanding of the dyslipidemia-related signaling pathways and specific mechanisms underlying dyslipidemia. Signaling pathways possess the ability to transmit an extracellular signal to the inside of the cell, leading to specific biological effects. Lipid metabolism disorders and lipid levels in the blood are frequently affected by aberrant alterations in the dyslipidemia-related signaling pathways. Therefore, further investigations into these pathways are required for the prevention and treatment of dyslipidemia. The present review summarizes the characteristics of six dyslipidemia-associated signaling pathways: Peroxisome proliferator-activated receptor, adenosine monophosphate-activated protein kinase, farnesoid X receptor, forkhead box O, adipocytokine and cyclic adenosine monophosphate signaling pathways. In particular, specific focus was placed on previous experimental studies and reports on the intervention effects of natural substances (compounds from animals, plants, marine organisms and microorganisms) on dyslipidemia.
Generating reliable estimates of tropical-cyclone-induced coastal hazards along the Bay of Bengal for current and future climates using synthetic tracks

Abstract. Deriving reliable estimates of design water levels and wave conditions resulting from tropical cyclones is a challenging problem of high relevance for, among other things, coastal and offshore engineering projects and risk assessment studies. Tropical cyclone geometry and wind speeds have been recorded for the past few decades only, thus resulting in poorly reliable estimates of the extremes, especially in regions characterized by a low number of past tropical cyclone events. In this paper, this challenge is overcome by using synthetic tropical cyclone tracks and wind fields generated by the open-source tool TCWiSE (Tropical Cyclone Wind Statistical Estimation Tool) to create thousands of realizations representative of 1000 years of tropical cyclone activity for the Bay of Bengal. Each of these realizations is used to force coupled storm surge and wave simulations by means of the processed-based Delft3D Flexible Mesh Suite. It is shown that the use of synthetic tracks provides reliable estimates of the statistics of the first-order hazard (i.e., wind speed) compared to the statistics derived for historical tropical cyclones. Based on estimated wind fields, second-order hazards (i.e., storm surge and waves) are computed that are generated by the first-order hazard of wind. The estimates of the extreme values derived for wind speed, wave height and storm surge are shown to converge within the 1000 years of simulated cyclone tracks. Comparing second-order hazard estimates based on historical and synthetic tracks shows that, for this case study, the use of historical tracks (a deterministic approach) leads to an underestimation of the mean computed storm surge of up to −30 %. Differences between the use of synthetic versus historical tracks are characterized by a large spatial variability along the Bay of Bengal, where regions with a lower probability of occurrence of tropical cyclones show the largest difference in predicted storm surge and wave heights. In addition, the use of historical tracks leads to much larger uncertainty bands in the estimation of both storm surges and wave heights, with confidence intervals being +80 % larger compared to those estimated by using synthetic tracks (probabilistic approach). Based on the same tropical cyclone realizations, the effect that changes in tropical cyclone frequency and intensity, possibly resulting from climate change, may have on modeled storm surge and wave heights was computed. As a proof of concept, an increase in tropical cyclone frequency of +25.6 % and wind intensity of +1.6 %, based on literature values and without accounting for uncertainties in future climate projection, was estimated to possibly result in an increase in storm surge and wave heights of +11 % and +9 %, respectively. This suggests that climate change could increase tropical-cyclone-induced coastal hazards more than just the actual increase in maximum wind speeds.
Potential Applications of CE-2 Microwave Radiometer Data in Understanding Basaltic Volcanism in Heavily Ejecta-Contaminated Mare Frigoris

Mare Frigoris is the fifth largest and almost northernmost mare located on the near side of the Moon. Mare Frigoris has an elongated shape, with a length of approximately 1500 km and a width of approximately 200 km, which makes it susceptible to becoming contaminated by the impact ejecta from the nearby highlands. Comparatively speaking, microwave radiometer (MRM) data have good penetration capabilities. Therefore, the MRM data from Chang’e-2 satellite were employed to study the volumetric thermal emission features of basaltic deposits in Mare Frigoris. Combining the MRM data with the basaltic units with FeO and TiO2 abundances identified using the small crater rim and ejecta probing (SCREP) methodology and with the gravity from Gravity Recovery and Interior Laboratory (GRAIL), the four potential conclusions that were obtained are as follows: (1) The MRM data are strongly related to the (FeO + TiO2) abundance of pristine basalts and are less influenced by ejecta contamination; (2) in every quadrant of Mare Frigoris, the (FeO + TiO2) abundance of the basalt decreases with an increase in age; (3) at least in Mare Frigoris, the main influencing factor regarding the brightness temperature remains the (FeO + TiO2) abundance of surface deposits; (4) a warm microwave anomaly was revealed in the western-central and eastern-central areas of Mare Frigoris which has a strong relationship with the positive Bouguer gravity anomaly derived from GRAIL data in terms of spatial distribution. The results are significant in the context of improving our understanding the basaltic igneous rock and thermal evolution of the Moon using MRM data.
Prognostic Value of Platelet to Lymphocyte Ratio in Sepsis: A Systematic Review and Meta-analysis

The goal of this study was to conduct a systematic review of the literature on the relationship between peripheral blood platelet to lymphocyte ratio (PLR) and mortality in sepsis and to integrate the findings in a meta-analysis. An electronic search of three main databases was performed: PubMed, Embase, and Scopus on 19 December 2021. Finally, 16 studies comprising 2403 septic patients, including 1249 survivors and 1154 nonsurvivors, were included in this meta-analysis. We found that PLR levels were significantly higher in nonsurvivors than in survivors (random effect model: SMD = 0.72, 95% CI; 0.35–1.10, p < 0.001). However, significant heterogeneity was observed across the studies (I2 = 94.1%, p < 0.01). So, we used random effect model in our meta-analysis. In the subgroup analysis, according to mortality time, patients deceased during one month after sepsis had elevated levels of PLR compared to survivors (SMD = 1.03, 95% CI = 0.15-1.92, p = 0.22). However, in-hospital mortality was not associated with PLR level (SMD = 0.41, 95% CI = −0.18-0.99, p = 0.175). Our findings support PLR to be a promising biomarker that can be readily integrated into clinical settings to aid in the prediction and prevention of sepsis mortality.