Miracle-dz/UniFAR-FTUs huggingface dataset:
A Network Pharmacology-Based Strategy for Predicting Active Ingredients and Potential Targets of Shuilu Erxian Dan in Treating Diabetic Kidney Disease

Background and objective: Recent years, some Chinese scholars have applied Shuilu Erxian Dan (SED) to the treatment of treating diabetic kidney disease (DKD) and achieved well curative effect. However, these studies are mostly limited to clinical observation. This study aimed to explore the molecular mechanisms of SED in treating DKD. Methods The active components of SED were retrieved in TCMSP database and BATMAN-TCM database, and the herbal targets were obtained by drugbank database and SwissTargetPrediction platform. The gene expression data of DKD patients were downloaded from GEO database and analyzed to obtain DKD-related targets. The ingredient-target network and the PPI network were constructed by Cytoscape software. The clusterProfiler package of R software is used for bioinformatic analysis. Molecular docking was further applied to verify the interaction between compounds and targets by Autodock Vina software. Results 610 differential expressed genes of DKD patients were obtained, and 29 potential targets of SED against DKD were screened out (including PPTGS2, FABP3, HSD17B2, FABP1, HSD11B2, CYP27B1, JUN, UGT2B7, VCAM1, CA2, MAOA, MMP2, CXCR1, SLC22A6, EPHX2, SLC47A1, FOS, EGF, CCL2, COL3A1, GSTA1, GSTA2, HSPA1A, DAO, ALDH2, ALB, GPR18, FPR2, and LPL). All the active ingredients in SED can act on the DKD-related targets, among which quercetin, Ellagic acid, and kaempferol may be the key active compounds. SED may play a therapeutic role in DKD by regulating pathways including “Fluid shear stress and atherosclerosis”, “AGE − RAGE signaling pathway in diabetic complications” and “IL-17 signaling pathway”. Conclusion This study suggests that the mechanism of SED treating DKD is a complex network with multi-target and multi-pathway, which provides a reference for future experimental studies.
BIOLOGICAL ASPECTS OF THE TRUE SPIDER KOCHIURA AULICA (ARANEIDA: THERIDIIDAE) REARED ON THE FIRST LARVAL STAGE OF SPODOPTERA LITTORALIS IN EGYPT

Specimens of Kochiura aulica spider were collected from cotton crops in Qalyubia governorate during season 2017. Spiders were associated with the leaf cotton worm, Spodoptera littoralis (Boisduval, 1833) larvae. The spider Kochiura aulica (C.L. Koch, 1838) had 5 spiderlings for female and male. Individuals of the spider K. aulica were reared on the first larval stage of S. littoralis under laboratory conditions at three constant temperatures (20, 25 and 30°C and 60-70% R.H). The first spiderling recorded the longest duration compared to other spiderlings of female and male when fed on 1st larval stage of S. littoralis at three constant temperatures. Results indicate that individuals of K. aulica which were reared at 30 °C developed faster than those reared at 20 and 25 °C. The life cycle of K. aulica was the shortest when the spider reared at 30°C averaged 79.3 and 76.2 days followed by 25°C averaged 103 and 98.3 days and the longest values was 123.7 and 118.2 days at 20°C for female and male, respectively with significant differences among the three constant temperatures. Prey consumption was calculated for different stages. Effect of constant temperatures on longevity, life span and fecundity of the spider were studied. The number of consumed preys was the highest at 30 °C and the lowest at 20 °C. Also, the number of egg sacs per female was the highest at 30 °C and the lowest at 20 °C.
Apprenticeship System of ’’Wayside" Seamstresses From Selected Neighbourhoods in Accra.

The purpose of this study was to investigate the apprenticeship system of fifty seamstresses and fifty apprentices from Achimota, Legon and Madina neighbourhoods of Accra. A stratified sampling technique was used to select the respondents from these neighbourhoods. The respondents were interviewed by the researcher, using two separate structured questionnaires: One for the seamstresses and the other for the apprentices. A non-obtrusive observational guide was also used to evaluate teaching/learning interactions at the workshop. Frequency, percentage distribution and cross-tabulation were used to analyze the data. Fathers with low level of education endorsed apprenticeship for their daughters (Ref. Appendix VI). The study revealed that the seamstresses were aged between 20 and 40. Their educational attainment ranged from primary six to university. Eighty-two percent had their professional training informally in kiosks while the rest either attended formal vocational training schools or had no formal training in sewing. The apprentices were aged between 15 and 33 years. The educational level of 90% of the apprentices ranged from primary to vocational school. Ten percent had had no formal education. An aspirant apprentice ought to be introduced to a seamstress by a respectable member of her family who would be the guarantor. Apprenticeship fees ranging from 020,000 to 0120,000 were paid for a period of two and a half years apprenticeship, in addition to six months service to sew with the trainer without being paid. The apprenticeship system was devoid of theory work, with an average of seven hours each day spent on some sewing activity. Teaching and learning were through demonstration by the seamstress, observation and practice by the apprentices who most of the time taught one another (peer teaching). Eighty-two percent of the
International science and technology conference “Earth science”

Preface D.B. Solovev1,2 1 Far Eastern Federal University, Vladivostok, Russia 2 Vladivostok Branch of Russian Customs Academy, Vladivostok, Russia E-mail: solovev.db@dvfu.ru International science and technology conference “Earth science” (ISTCEarthScience) it is a subsection of a big conference the International Scientific Conference “FarEastCon” took place on October 2-4, 2018 in Vladivostok, Russian Federation. The conference represents an informational platform for accumulation of expert opinion on projects and initiatives that are aimed at implementation of farsighted scientific research and development; it allows to present scientific and practical achievements to a wide circle of researchers. Sections of the conference are of interest for the broad range of experts in the sphere of development of innovative solutions and organizing events that increase the efficiency of economic and innovative activities. The international program committee has selected some papers for publishing in the IOP Conference Series: Earth and Environmental Science. ISTCEarthScience is a high-quality conference with a competitive submission process. For example, in 2018, ISTCEarthScience only accepted 30% of submitted papers. ISTCEarthScience has a rigorous reviewing process that is similar to the processes used by IEEE. Every submitted paper and poster is subjected to this process. The main criterion is a judgment of the degree to which the submitted paper contributes substantial new research. Reviewers rate the paper using a 10-point ranking scale, and provide a written evaluation. The written evaluation needs to support the reasoning behind the numeric ranking. After the review period, there is a discussion period, where all reviewers can see the other reviews. Organizing committee would like to express our sincere appreciation to everybody who has contributed to the conference. Heartfelt thanks are due to authors, reviewers, participants and to all the team of organizers for their support and enthusiasm which granted success to the conference. Conference Char, Denis B. Solovev.
Laboratory assessment of mechanical performanceand fume emissions of LEA® HWMA (90°C) vs. traditional HMA'160°C'

With the current trend in favour of reducing pollutant emissions and energy consumption, the road industry and bitumen manufacturers have also been pursuing a path of sustainable development. A series of new medium temperature coating and mixing technologies, under the label warm and half-warm asphalt mixes have come to the fore. A study, carried out in the laboratory within the framework of a partnership established between EIFFAGE Travaux Publics and IFSTTAR, aimed at correlating potential fume emissions with mixing parameters for asphalt mixes, in relation to the mix mechanical properties and to bitumen ageing. This study demonstrates that a decrease in manufacturing temperature leads to a global emissions reduction as well as slower bitumen ageing. Results obtained highlight the influence of mix parameters and processes, especially regarding fume emissions for both half-warm and hot mix asphalts (hma). As for the mechanical performance and durability of LEA® mixes, their complex modulus and fatigue resistance characteristics are similar to those of traditional hma.
TWO-LANE HIGHWAY CAPACITY AND LEVEL OF SERVICE RESEARCH PROJECT: PHASE III - FINAL REPORT

This document represents the third and last phase of the Transportation Association of Canada's (TAC's) "Two-Lane Highway Capacity and Level of Service Research Project". The project, initiated in 1982, is comprised of three phases: 1) Study design, 2) Data collection, and 3) Data analysis, evaluation of the U.S. Highway Capacity Manual (HCM), and development of a Canadian methodology. Due to insufficient resource availability, one of the original objectives of the third phase, the development of a Canadian level of service (LOS) methodology, was dropped. It was agreed to concentrate on evaluating the applicability of the HCM LOS methodology to Canadian two-lane highways. As well, it was decided to prepare and disseminate the significant traffic/driver perception database (the results of Phase 2 - Data collection). The basic finding of the traffic data analysis project was that the HCM LOS procedure is generally conservative in rating Canadian highway operations. The HCM-predicted platooning levels are generally much higher than observed values, particularly on the rolling and mountainous terrain sections. A supplementary analysis, concentrating on the terrain classification effects, shows that the use of rolling or mountainous designations degrades the accuracy of the platooning predictions and it is recommended that these factors not be used in future HCM applications. The HCM-predicted mean travel speeds are generally, but not exclusively, lower than observed speeds. The platooning and speed results cause the HCM to rate the service levels lower than indicated by the field data. Finally, a number of recommendations are presented concerning areas requiring further research. Also available upon request are two technical supplements (one which presents the 43 data collection sites and the other which describes the traffic and driver perception data) and three accompanying data diskettes.
Describing Bank Equity Returns: The Year-by-Year Record

1. lntroduction The market model of Sharpe [11] is widely embraced by both the professional and academic communities as the premier characterization of the return generating mechanism for common stocks. The present study is focused upon an allegation that appears in the intermediation folklore and literature, namely, that banks' stock returns are produced by a regime different from that of typical listed equities and hence do not subscribe to the market model paradigm. Such a prospect is of critical importance since it impinges upon the equity financing decisions of bankers and supervision of bank capital adequacy by regulators. The conventional wisdom and past empirical investigations are overviewed in section 2. Section 3 includes descriptions of the statistical procedures employed and results of the tests. As a summary of the substantive results, conventional wisdom is for the most part rebutted. The evidence suggests that the market model is consistently a slightly better characterization of bank equity returns than industrials.
Feasibility of static computational fluid dynamics simulations around a specialised delta wing configuration

The goal of this paper was to determine if it was feasible to accurately model the full static angle of attack range in Computational Fluid Dynamics (CFD) applications while determining associated model dependencies. If successful, this would be a step towards CFD being utilised as a more reliable tool in the development of aircraft. This process could reduce the reliance on wind tunnel results with a consequent reduction in development costs. The test bed used for this paper was based on a specialised delta wing configuration. The study was undertaken by comparing simulation parameters such as mesh resolution, Discretisation schemes, turbulence and transition models, time step sizes and the order of the time integration operator. The analysis was completed using specialised meshing software, the flow simulation software (TAU) developed by the German Aerospace Agency (DLR) and the graphical interface Tecplot. Findings indicated that the capabilities to accurately model the flight envelope of the configuration are available but are also limited. Results showed the difficulties in utilising one CFE model to represent the entire angle of attack range and the large effects model dependencies can have on results.
Effect of the COVID-19 pandemic on health facility delivery in Ethiopia; results from PMA Ethiopia’s longitudinal panel

Objectives To examine the effect of COVID-19 on health facility delivery in Ethiopia. Design We used longitudinal data with a pre-post exposure to the pandemic to assess change in facility delivery patterns nationally and by urban and rural strata. We conducted design-based multivariable multinomial logistic regression comparing home, lower-level facility, and hospital delivery with date of birth as a spline term, with a knot indicating births before and on/after April 8, 2020. Setting Six regions in Ethiopia, covering 91% of the population. Participants Women were eligible to participate if they were currently pregnant or less than six weeks postpartum and were recontacted at six weeks, six months, and one year postpartum. 2,889 women were eligible and 2,855 enrolled. Data used in this paper come from the six-week interview, with a follow-up rate of 88.9% (2,537 women). Results In urban areas, women who delivered during the COVID-19 pandemic had a 77% reduced relative risk of delivering in a hospital relative to women who delivered prior to the pandemic (aRRR: 0.23, 95% CI: 0.07–0.71). There were no significant differences between the pre- and COVID-19 periods within rural strata where the majority of women deliver at home (55.6%). Overall, the effect was non-significant at a national level. Among women who delivered during the COVID-19 pandemic, 20.0% of urban women said COVID-19 affected where they delivered relative to 8.7% of rural women (p-value = 0.01). Conclusion We found that delivery patterns in urban areas changed during the early months of the COVID-19 pandemic, but there was no evidence of large-scale declines of hospital delivery at the national level. Concerns about COVID-19 transmission in health facilities and ensuring lower-level facilities are equipped to address obstetric emergencies are critical to address. COVID-19 will likely slow progress towards increasing rates of institutional delivery in urban areas in Ethiopia.
Fejeskáposzta-fajták ellenállósága a dohánytripsszel szemben

2004-ben es 2005-ben 22 fejeskaposzta-fajta dohanytripsz ellenallosagat ertekeltem hazankban ket helyszinen, a fejet alkoto leveleken kialakult kartetel alapjan. Minden fajta eseteben 10 betakaritasra erett kaposztafej valamennyi karositott levelen feljegyeztem a karosodott terulet nagysagat a teljes leveloldal feluletenek aranyaban. A fajtak ellenallosaganak jellemzesere ezeknek a levelenkent fel-jegyzett ertekeknek az osszegekent kepzett merő-szamot hasznaltam, ami a fej belsejeben kialakult osszes kartetelt fejezi ki. Az ertekelesek soran a karositott fejlevek szamat is feljegyeztem, amit szinten felhasznaltam a fajtak ellenallosaganak jellemzesere. Minden fajtan kialakult kisebb-nagyobb kar-tetel. Mindazonaltal, a Balashi F1, a Bloktor F1 es a Bravo F1 fajtak karosodtak a legkisebb mertekben, ezert ezeket a fajtakat a dohanytripsszel szemben rezisztensnek minősitettem. Megallapitottam, hogy az ertekelesek helyszine es evjarata is befolyasolta ugyanazon fajtak eseteben kialakult kartetel merte-ket.
Transcriptome analysis of the sex pheromone gland and pheromone biosynthetic pathway in Eogystia hippophaecolus

Abstract The moth Eogystia hippophaecolus (Hua et al.) is a major threat to sea buckthorn plantations in China. Specific and highly efficient artificial sex pheromone traps have been developed and used to control this pest species. However, the biosynthesis of sex pheromones Z7-14:Ac and E3-14:Ac remains poorly understood.Results We investigated the female pheromone gland transcriptome of E. hippophaecolus and identified two pheromone biosynthesis-activating neuropeptides (PBANs), two pheromone biosynthesis-activating neuropeptide receptors (PBANrs), five acetyl-CoA carboxylases (ACCs), six fatty acid synthases (FASs), 16 Acyl-CoA desaturases (DESs), 26 reductases (REDs), 13 acetyltransferases (ACTs), one fatty acid transport protein (FATP), one acyl-CoA-binding protein (ACBP), and five elongation of very long-chain fatty acid proteins (ELOs) in pheromone biosynthesis pathways. Additionally, we identified 11 odorant-degrading enzymes (ODEs) and 16 odorant-binding proteins (OBPs), 14 chemosensory proteins (CSPs), two sensory neuron membrane proteins (SNMPs), three odorant receptors (ORs), seven ionotropic receptors (IRs), and six gustatory receptors (GRs). Conclusions 77 unigenes involved in female pheromone biosynthesis, 31 chemoreception proteins and 11 odorant degradation enzymes were identified, which provided insight into the regulation of the pheromone components and pheromone recognition in the sex gland, and knowledge pertinent to new integrated pest management strategy of interference pheromone biosynthesis and recognition.
Microcomputer based controller for the Langley 0.3-meter Transonic Cryogenic Tunnel

Flow control of the Langley 0.3-meter Transonic Cryogenic Tunnel (TCT) is a multivariable nonlinear control problem. Globally stable control laws were generated to hold tunnel conditions in the presence of geometrical disturbances in the test section and precisely control the tunnel states for small and large set point changes. The control laws are mechanized as four inner control loops for tunnel pressure, temperature, fan speed, and liquid nitrogen supply pressure, and two outer loops for Mach number and Reynolds number. These integrated control laws have been mechanized on a 16-bit microcomputer working on DOS. This document details the model of the 0.3-m TCT, control laws, microcomputer realization, and its performance. The tunnel closed loop responses to small and large set point changes were presented. The controller incorporates safe thermal management of the tunnel cooldown based on thermal restrictions. The controller was shown to provide control of temperature to + or - 0.2K, pressure to + or - 0.07 psia, and Mach number to + or - 0.002 of a given set point during aerodynamic data acquisition in the presence of intrusive geometrical changes like flexwall movement, angle-of-attack changes, and drag rake traverse. The controller also provides a new feature of Reynolds number control. The controller provides a safe, reliable, and economical control of the 0.3-m TCT.
Mobile Learning Applications in Early Childhood Education

The chapter presents the results of a project in which tablets were used for teaching natural sciences to kindergarten students. The classification of animals depending on certain characteristics was the subject matter. Forty-five students participated, divided into three groups. The first used printed material, the second used computers and webpages, and the third used tablets and AR applications. Bybee’s 5Es provided the teaching framework for all groups. Data were collected using evaluation sheets and structured interviews. The students in the tablets’ group performed better in all the evaluation sheets compared to the ones who were taught using printed material, but there were no statistically significant differences compared to the computers’ group. A positive impact on motivation and enjoyment was noted in the tablets’ group. Thus, it can be concluded that tablets are an interesting alternative teaching tool for very young students. Implications for research and practice are also discussed.
Post-Acute Respiratory Distress Syndrome Pulmonary Fibrosis and Pulmonary Artery Hypertension in Patients Affected by Severe COVID19

Rationale:Many patientswith COVID19 who develop acute respiratory distress syndrome (ARDS) survive the acute phase of the illness ,a substantial proportion die as a result of progressive pulmonary fibrosis.The evaluation of corellation between pulmonary fibrosis after ARDS and development of pulmonary hypertension(PH) in COVID19 patients is very interesting in term on management of pulmonary fibrosis for further prevention of PH.Objective:The aim of this study was to determine the impact of pulmonary fibrosis on development of pulmonary hypertension in COVID19 patients and possibility of use of antifibrotic drugs in such patients.Methods and measurements:It was randomized and controlled study which is included 68 survivors patients with pulmonary fibrosis after ARDS in outpatient settings of Medical University ,Baku city.In all patients have invastigated the 6 minute walk distance(6MWD) ,exersice desaturation,echocariography with further measurement of the pulmonary artery pressure by using RHC,CT scan of the lungs,and pulmonary lung functions(spirometry and DLco). Results:In 41 of 68 (60%)survivors was developed PH and the degree of pulmonary hypertension severity was depneding on the extention of fibrotic and interstitial changes in lung assessing by lung CT scan.In all patients with PH (median range was 40.25+-12.86 mmHg) the 6MWD was significantly less compared to non-PH patients(220+-54m vs 390+-62m;p&lt;0.001);exersice desaturation was significantly lower in patient with PH (10+-4% vs 6+-2 %;p&lt;0.001);lung function although was lower (FVC :43.8+-12.5 vs 60.1+-8.7;p&lt;0.004);diffusing capacity of the lung was markedly lower(DLco:38.54+-10.44 vs 58.65+-11.82;p&lt;0.001). Antifibrotic drug Pifenidone was used to in 14 patients swith pulmonary fibrosis and PH.After three moinths treatment with this drug there was significantly improvement of 6MWD(=0.01),lung function(&lt;0.001),exersice desaturation(=0.01),extention of CT changes(=0.006), and pulmonary artery pressure(=0.004). Conclusion: Pulmonary fibrosis and related to its PH is common in survivors patients with COVID19 complicated with ARDS . After dicharge from hospitals all such patients have to assess regularly for presence of pulmonary hypertension and the level of PH will depends on the severity of extetion of the lung fibrosis. Antifibrotic drug pirfenidone is useful in terms of reducing extention of lung fibrosis ,improving lung function and decreasing pulmonary artery pressure.