Miracle-dz/UniFAR-FTUs huggingface dataset:
Application Progress of Bevacizumab in Neoadjuvant Therapy for Locally Advanced Rectal Cancer

: Rectal cancer is a common malignant tumor of the digestive tract, and most patients with locally advanced stage cannot be directly surgically removed. Neoadjuvant therapy can reduce the tumor staging of patients, and then accept surgical treatment, improve the quality of life and the prognosis. Bevacizumab can inhibit the formation of tumor angiogenesis, in recent years, it has been used in neoadjuvant therapy for locally advanced rectal cancer, and has achieved certain clinical efficacy. In this summary, we have reviewed the recent literatures on bevacizumab in neoadjuvant therapy for locally advanced rectal cancer, and summarized them to provide some references for clinical application.
Cost Efficiency Through the use of the EOQ Method

This study aims to analyze and show how to calculate EOQ and prove that the use of the EOQ method can make inventory costs efficient because the number of purchases is not excessive and not lacking, the frequency of purchases and the exact time of reordering. The theory underlying this research is the theory of inventory management, especially the EOQ Single Item Method. The analysis technique used is descriptive analysis using the EOQ Single Item method to calculate Optimalization EOQ , purchase frequency (N), and Reorder Point (ROP) The results showed that inventory cost efficiency can be achieved through the use of the EOQ method which is indicated by the optimalization EOQ, smaller purchase frequency and cheaper inventory costs compared to determining the amount of inventory, purchase frequency, time of order and inventory costs POX’Tempe Business
Business intelligence, management control systems and startup performance: Empirical study from Indonesia

This study aimed to examine the relationship between business intelligence and management control systems and how they impact company performance. It used 209 startup companies recorded in the database of the Ministry of Tourism and Creative Economy Republic of Indonesia. The sample consists of startups less than ten years old and experiencing a period of growth. The partial least squares SEM (PLS-SEM) is used to estimate cause-effect relationship models. The finding shows that the management control system positively contributes to the company's performance. The moderation analysis concludes that business intelligence is not able to moderate the relationship between management control systems and company performance. This finding supports the contingency theory, which claims the need to evaluate conditional factors in creating effective management control. Also, the theory emphasizes the alignment between management control and company performance to support performance improvement. This research provides practical implications for startups about the importance of creating a more contextual management control system to improve company performance.
Effects of Adapted Mindfulness Training on Interoception and Adherence to the Dietary Approaches to Stop Hypertension (DASH) Diet: The MB-BP Randomized Clinical Trial

Background: Hypertension is a major cause of cardiovascular disease. The Dietary Approaches to Stop Hypertension (DASH) diet lowers blood pressure (BP). However, adherence is typically low. Mindfulness training adapted to improving health behaviors that lower BP could improve DASH adherence, in part through improved interoceptive awareness relevant to dietary consumption. The primary objective of the MB-BP trial was to evaluate effects of the Mindfulness-Based Blood Pressure Reduction (MB-BP) program on interoceptive awareness. Secondary objectives assessed whether MB-BP impacts DASH adherence, and explored whether interoceptive awareness mediates DASH dietary changes. Methods: Parallel-group phase 2 randomized clinical trial conducted from June 2017-November 2020 with 6 months follow-up. Data analyst was blinded to group allocation. Participants had elevated unattended office BP (120/80 mmHg). We randomized 201 participants to MB-BP (n=101) or enhanced usual care control (n=100). Loss-to-follow-up was 11.9%. Outcomes were the Multidimensional Assessment of Interoceptive Awareness (MAIA; range 0-5) score, and the DASH adherence score (range 0-11) assessed via a 163-item Food Frequency Questionnaire. Results: Participants were 58.7% female, 81.1% non-Hispanic white, with mean age 59.5 years. Regression ana lyses demonstrated that MB-BP increased the MAIA score by 0.54 (95% CI: 0.35,0.74; p<.0001) at 6 months follow-up vs. control. MB-BP increased the DASH score by 0.62 (95% CI: 0.13,1.11; p=0.01) at 6 months vs. control, in participants with poor DASH adherence at baseline. Conclusions: A mindfulness training program adapted to improving health behaviors that lower BP improved interoceptive awareness and DASH adherence. MB-BP could support DASH dietary adherence in adults with elevated BP.
Valve Sparing Aortic Root Replacement: long term predictors of outcomes and mortality

Introduction In aortic root surgery, Valve Sparing Aortic Root Replacement (VSARR) is an attractive alternative by mitigating the risks inherent to prosthetic valves, however little is known about the variables that impact its performance and durability. We have reviewed our mid to long-term outcomes following VSARR and describe factors that impact patient survival and aortic valve reintervention and insufficiency. Methods A retrospective review of 284 consecutive patients undergoing VSARR between November 1999 and January 2022 at Austin Health, Melbourne, Australia, was undertaken, with median follow up of 6.43 ? 4.83 years, but up to 22.0 years. Results The median age at intervention was 60.0 years (IQR 48.0-67.0), of which 68 (23.9%) had bicuspid aortic valve (BAV) disease, 27 (9.5%) Marfan? s disease, 119 (41.9%) severe aortic root dilation (>50mm), and 155 (54.6%) severe aortic insufficiency at the time of intervention. The 30-day mortality was 1.8%, with freedom from mortality of 96.0% (95% CI 92.6-97.8%) at 5 years, 88.2% (95% CI 81.4-92.6%) at 10 years and 78.6% (66.2-86.9%) at 15 years. Freedom from aortic re-intervention was 92.2% (95% CI 87.7-95.2%) at 5 years, 79.8% (95% CI 71.8-85.8%) at 10 years, and 74.1% (63.5-82.0%) at 15 years. Predictors of re-intervention were concomitant leaflet repair (HR 8.13, 95%CI 1.07-61.7) and bicuspid valvulopathy (HR 2.23, 95% CI 1.07-4.68). The freedom from aortic insufficiency was 89.1% (95% CI 83.5-92.9%), 84.9% (95% CI 77.8-89.9%) and 80.7% (71.0-87.4%) at 5-, 10- and 15- years respectively. Conclusion VSARR has excellent long-term outcomes, with low mortality and re-intervention rates. Concomitant Leaflet repair and Bicuspid Aortopathy are the only long-term predictors of re-intervention.
Deep Convection and Column Water Vapor over Tropical Land versus Tropical Ocean: A Comparison between the Amazon and the Tropical Western Pacific

AbstractThe relationships between the onset of tropical deep convection, column water vapor (CWV), and other measures of conditional instability are analyzed with 2 yr of data from the DOE Atmospheric Radiation Measurement (ARM) Mobile Facility in Manacapuru, Brazil, as part of the Green Ocean Amazon (GOAmazon) campaign, and with 3.5 yr of CWV derived from global positioning system meteorology at a nearby site in Manaus, Brazil. Important features seen previously in observations over tropical oceans—precipitation conditionally averaged by CWV exhibiting a sharp pickup at high CWV, and the overall shape of the CWV distribution for both precipitating and nonprecipitating points—are also found for this tropical continental region. The relationship between rainfall and CWV reflects the impact of lower-free-tropospheric moisture variability on convection. Specifically, CWV over land, as over ocean, is a proxy for the effect of free-tropospheric moisture on conditional instability as indicated by entraining plu.
Predictors of the 6-year outcome of obsessive-compulsive disorder: Findings from the Netherlands Obsessive-Compulsive Disorder Association study

Objective: Obsessive-compulsive disorder is characterized by a chronic course that can vary between patients. The knowledge on the naturalistic long-term outcome of obsessive-compulsive disorder and its predictors is surprisingly limited. The present research was designed to identify clinical and psychosocial predictors of the long-term outcome of obsessive-compulsive disorder. Methods: We included 377 individuals with a current diagnosis of obsessive-compulsive disorder, who participated in the Netherlands Obsessive Compulsive Disorder Association study, a multicenter naturalistic cohort study. Predictors were measured at baseline using self-report questionnaires and clinical interviews. Outcome was assessed using the Yale-Brown Obsessive Compulsive Scale at 2-, 4- and 6-year follow-up. Results: The overall course of obsessive-compulsive disorder was characterized by two prominent trends: the first reflected an improvement in symptom severity, which was mitigated by the second, worsening trend in the long term. Several determinants affected the course variations of obsessive-compulsive disorder, namely, increased baseline symptom severity, late age of onset, history of childhood trauma and autism traits. Conclusion: The long-term outcome of obsessive-compulsive disorder in naturalistic settings was characterized by an overall improvement in symptom severity, which was gradually halted to the point of increased worsening. However, after 6 years, the severity of symptoms remained below the baseline level. While certain determinants predicted a more favorable course, their effect diminished over time in correspondence to the general worsening trend. The results highlight the importance of a regular and continuous monitoring for symptom exacerbations as part of the management of the obsessive-compulsive disorder, regardless of the presence of putative predictors.
A bespoke sleep monitoring and sleep hygiene intervention improves sleep in an U18 professional football player: A case study

ABSTRACT This case study reports on a professional football player (age: 17.6 years) who was referred for sleep monitoring and intervention after reporting excessive night-time awakenings. The player undertook a series of subjective sleep assessments and objective sleep monitoring (activity monitor). Based on the data presented, a sleep hygiene intervention was prescribed. Numerical comparisons were made between pre-intervention (Pre) and post-intervention (Post) values. Objective values were also compared to reference data from a similarly aged professional cohort from the same club (n = 11). Wake episodes per night (Pre: 7.9 ± 3, Post: 4.5 ± 1.9; −43%) and wake after sleep onset (WASO; Pre: 74.3 ± 31.8 mins, Post: 50.0 ± 22.8 mins, −33%) were improved from Pre to Post. Compared to the reference data, mean wake episodes per night (Pre: 7.9 ± 3.0, reference: 4.6 ± 2.6; −42%) and WASO (Pre: 74.3 ± 31.8 mins, reference: 44.3 ± 36.5 mins; −40%) were all lower compared to Pre levels. Whilst causality cannot be proven, we observed multiple sleep metrics improving following an intervention. This provides a potential framework for practitioners looking to provide targeted sleep assessment and intervention.
Evaluation of Archival HIV DNA in Brain and Lymphoid Tissues

HIV infection of the brain is associated with adverse neuropsychiatric outcomes, despite efficient antiretroviral treatment. HIV may persist in reservoirs in the brain and other tissues, which can seed virus replication if treatment is interrupted, representing a major challenge to cure HIV. ABSTRACT HIV reservoirs persist in anatomic compartments despite antiretroviral therapy (ART). Characterizing archival HIV DNA in the central nervous system (CNS) and other tissues is crucial to inform cure strategies. We evaluated paired autopsy brain—frontal cortex (FC), occipital cortex (OCC), and basal ganglia (BG)—and peripheral lymphoid tissues from 63 people with HIV. Participants passed away while virally suppressed on ART at the last visit and without evidence of CNS opportunistic disease. We quantified total HIV DNA in all participants and obtained full-length HIV-envelope (FL HIV-env) sequences from a subset of 14 participants. We detected HIV DNA (gag) in most brain (65.1%) and all lymphoid tissues. Lymphoid tissues had higher HIV DNA levels than the brain (P < 0.01). Levels of HIV gag between BG and FC were similar (P > 0.2), while OCC had the lowest levels (P = 0.01). Females had higher HIV DNA levels in tissues than males (gag, P = 0.03; 2-LTR, P = 0.05), suggesting possible sex-associated mechanisms for HIV reservoir persistence. Most FL HIV-env sequences (n = 143) were intact, while 42 were defective. Clonal sequences were found in 8 out of 14 participants, and 1 participant had clonal defective sequences in the brain and spleen, suggestive of cell migration. From 10 donors with paired brain and lymphoid sequences, we observed evidence of compartmentalized sequences in 2 donors. Our data further the idea that the brain is a site for archival HIV DNA during ART where compartmentalized provirus may occur in a subset of people. Future studies assessing FL HIV-provirus and replication competence are needed to further evaluate the HIV reservoirs in tissues. IMPORTANCE HIV infection of the brain is associated with adverse neuropsychiatric outcomes, despite efficient antiretroviral treatment. HIV may persist in reservoirs in the brain and other tissues, which can seed virus replication if treatment is interrupted, representing a major challenge to cure HIV. We evaluated reservoirs and genetic features in postmortem brain and lymphoid tissues from people with HIV who passed away during suppressed HIV replication. We found a differential distribution of HIV reservoirs across brain regions which was lower than that in lymphoid tissues. We observed that most HIV reservoirs in tissues had intact envelope sequences, suggesting they could potentially generate replicative viruses. We found that women had higher HIV reservoir levels in brain and lymphoid tissues than men, suggesting possible sex-based mechanisms of maintenance of HIV reservoirs in tissues, warranting further investigation. Characterizing the archival HIV DNA in tissues is important to inform future HIV cure strategies.
What if we have too many models of worry and GAD?

It is now almost 40 years since Borkovec and colleagues provided this definition in their seminal paper and so launched the modern psychological study of worry, and by extension generalized anxiety disorder (GAD). Their classic definition has inspired and guided the developments of models and treatments since, and within this definition we can find some of the differences in emphasis between the models as well as the ongoing debates. These include the role of thoughts versus images, the function of worry, the role of affect or emotion, the degree to which worry is controllable, the role of uncertainty, and how worry may relate to fear. Interestingly, this definition appeared in 1983, soon after the arrival of GAD as a diagnostic category in the third edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-III; American Psychiatric Association, 1980), following the decision to split the DSM-II (American Psychiatric Association, 1968) category of anxiety neurosis into GAD and panic disorder (see Crocq, 2022, for a historical overview). However, worry as a defining feature did not arrive until DSM-III-R (American Psychiatric Association, 1987). DSM-IV (American Psychiatric Association, 1994) reduced the list of associated symptoms, and the definition of GAD was relatively unaffected by DSM-5 (American Psychiatric Association, 2013). Therefore, we have had a reasonably stable definition of GAD with worry as a defining feature for almost 30 years, and now the 11th edition of the International Statistical Classification of Diseases and Related Health Problems (ICD-11; World Health Organization, 2022) broadly aligns with DSM-5. Despite definitional and diagnostic stability, our understanding of GAD in psychological terms is far from stable.
Application of Breathing Blunt Nose Concept to Lifting Body Configuration

Breathing blunt nose concept study, proposed for drag reduction, has been investigated for practical feasibility and application on lifting body configurations with the help of wind tunnel experiments carried out at Mach 7 on a 70° swept-back lifting body shape, and using shallow water channel visualization technique. The visualization results highlights the similarity between the flow field estimated by the two methods, and the latter provides an insight into the flow physics of inside the channel with an assumption of quasi one-dimensionality. The aerodynamic measurements at the wind tunnel demonstrate that with the breathing blunt nose, the drag can be reduced without adversely affecting the stability of the basic body, proving it worthy of practical utility, and underlines the existence of limit of bleeding from the nose.
Exploring the associations between the Morningness-Eveningness-Stability-Scale improved (MESSi) and the higher-order personality factors

ABSTRACT Morningness-eveningness refers to individual differences in the sleep-wake cycle. Research indicates that morningness-eveningness is associated with the Big Five (neuroticism, extraversion, openness to experience, agreeableness, conscientiousness) and the Big Two (alpha-stability, beta-plasticity) personality factors. However, the latter has not yet been tested within the multidimensional approach to morningness-eveningness. In the present study, we have adapted the Morningness-Eveningness-Stability-Scale improved (MESSi) to Polish (https://osf.io/rcxb5) to explore the associations between its subscales (morning affect, eveningness, distinctness) and the Big Two personality traits in a sample of 1106 participants (559 women and 547 men) aged 18 to 55 (M = 36.26, SD = 9.90). In bivariate correlations, morning affect was positively related to alpha-stability and beta-plasticity, distinctness was correlated negatively with alpha-stability and beta-plasticity, while eveningness was positively correlated only with beta-plasticity. Furthermore, the confirmatory factor analysis supported the original three-factor structure of the Polish version of MESSi, while the associations with affect and the symptoms of depression and anxiety attested to its validity. Overall, the present study provides the first evidence for the associations between MESSi subscales and the Big Two personality traits, as well as shows a good fit of the three-factor structure of MESSi in the Polish population.
Biomechanical Comparison of Distal Biceps Tendon Repair Techniques: Extracortical Single-Button Inlay Fixation Versus Intracortical Double-Button Onlay Anatomic Footprint Fixation

Background: Extracortical single-button (SB) inlay repair is a commonly used distal biceps tendon technique. However, complications (eg, neurovascular injury) and nonanatomic repairs have led to the development of intracortical fixation techniques. Purpose: To compare the biomechanical stability of extracortical SB repair with an anatomic intracortical double-button (DB) repair technique. Study Design: Controlled laboratory study. Methods: The distal biceps tendon was transected in 18 cadaveric elbows from 9 donors. One elbow of each donor was randomly assigned to the extracortical SB or anatomic DB group. Both groups were cyclically loaded with 60 N over 1000 cycles between 90° of flexion and full extension. The elbow was then fixed in 90° of flexion and the repair construct loaded to failure. Gap formation and construct stiffness during cyclic loading and ultimate load to failure were analyzed. Results: When compared with the extracortical SB technique after 1000 cycles, the anatomic DB technique showed significantly less gap formation (mean ± SD, 2.7 ± 0.8 vs 1.5 ± 0.9 mm; P = .017) and significantly more construct stiffness (87.4 ± 32.7 vs 119.9 ± 31.6 N/mm; P = .023). Ultimate load to failure was not significantly different between the groups (277 ± 93 vs 285 ± 135 N; P = .859). The failure mode in the anatomic DB group was significantly different from that of the extracortical SB technique (P = .002) and was due to fracture avulsion of the cortical button in 7 of 9 specimens (vs none in the SB group). Conclusion: Our study shows that the intracortical DB technique produces equivalent or superior biomechanical performance to that of the SB technique. The DB technique may offer a clinically viable alternative to the SB repair technique. Clinical Relevance: This study suggests, at worst, an equivalent and, at best, a superior biomechanical performance of intracortical anatomic DB footprint repair at the time of surgery. However, the mode of failure suggests that this technique should not be used in patients with poor bone quality.
Three-Dimensional Spheroid Culture of Human Mesenchymal Stem Cells: Offering Therapeutic Advantages and In Vitro Glimpses of the In Vivo State

Abstract As invaluable as the standard 2-dimensional (2D) monolayer in vitro cell culture system has been, there is increasing evidence that 3-dimensional (3D) non-adherent conditions are more relevant to the in vivo condition. While one of the criteria for human mesenchymal stem cells (MSCs) has been in vitro plastic adherence, such 2D culture conditions are not representative of in vivo cell-cell and cell-extracellular matrix (ECM) interactions, which may be especially important for this progenitor/stem cell of skeletal and connective tissues. The 3D spheroid, a multicellular aggregate formed under non-adherent 3D in vitro conditions, may be particularly suited as an in vitro method to better understand MSC physiological processes, since expression of ECM and other adhesion proteins are upregulated in such a cell culture system. First used in embryonic stem cell in vitro culture to recapitulate in vivo developmental processes, 3D spheroid culture has grown in popularity as an in vitro method to mimic the 3-dimensionality of the native niche for MSCs within tissues/organs. In this review, we discuss the relevance of the 3D spheroid culture for understanding MSC biology, summarize the biological outcomes reported in the literature based on such this culture condition, as well as contemplate limitations and future considerations in this rapidly evolving and exciting area.
Bottom-Up and Top-Down Approaches for the Design of Neuromorphic Processing Systems: Tradeoffs and Synergies Between Natural and Artificial Intelligence

While Moore’s law has driven exponential computing power expectations, its nearing end calls for new avenues for improving the overall system performance. One of these avenues is the exploration of alternative brain-inspired computing architectures that aim at achieving the flexibility and computational efficiency of biological neural processing systems. Within this context, neuromorphic engineering represents a paradigm shift in computing based on the implementation of spiking neural network architectures in which processing and memory are tightly colocated. In this article, we provide a comprehensive overview of the field, highlighting the different levels of granularity at which this paradigm shift is realized and comparing design approaches that focus on replicating natural intelligence (bottom-up) versus those that aim at solving practical artificial intelligence applications (top-down). First, we present the analog, mixed-signal, and digital circuit design styles, identifying the boundary between processing and memory through time multiplexing, in-memory computation, and novel devices. Then, we highlight the key tradeoffs for each of the bottom-up and top-down design approaches, survey their silicon implementations, and carry out detailed comparative analyses to extract design guidelines. Finally, we identify necessary synergies and missing elements required to achieve a competitive advantage for neuromorphic systems over conventional machine-learning accelerators in edge computing applications and outline the key ingredients for a framework toward neuromorphic intelligence.