Miracle-dz/UniFAR-FTUs huggingface dataset:
Characterizing the performance of intel optane persistent memory: a close look at its on-DIMM buffering

We present a comprehensive and in-depth study of Intel Optane DC persistent memory (DCPMM). Our focus is on exploring the internal design of Optane's on-DIMM read-write buffering and its impacts on application-perceived performance, read and write amplifications, the overhead of different types of persists, and the tradeoffs between persistency models. While our measurements confirm the results of the existing profiling studies, we have new discoveries and offer new insights. Notably, we find that read and write are managed differently in separate on-DIMM read and write buffers. Comparable in size, the two buffers serve distinct purposes. The read buffer offers higher concurrency and effective on-DIMM prefetching, leading to high read bandwidth and superior sequential performance. However, it does not help hide media access latency. In contrast, the write buffer offers limited concurrency but is a critical stage in a pipeline that supports asynchronous write in the DDR-T protocol. Surprisingly, in addition to write coalescing, the write buffer delivers lower than read and consistent write latency regardless of the working set size, the type of write, the access pattern, or the persistency model. Furthermore, we discover that the mismatch between cacheline access granularity and the 3D-Xpoint media access granularity negatively impacts the effectiveness of CPU cache prefetching and leads to wasted persistent memory bandwidth. Our proposition is to decouple read and write in the performance analysis and optimization of persistent programs. We present three case studies based on this insight and demonstrate considerable performance improvements. We verify the results on two generations of Optane DCPMM.
Predictive Modeling and Simulation to Identify the Prenatal, Natal, and Postnatal Risk Factors of Autism Spectrum Disorder: A Case Study from the Philippines

Perhaps the most crucial life skill is the ability to communicate effectively. Social interaction also shows positive feedback in our life. However, not everyone is capable of doing effective communication and social engagement. People have autism spectrum disorder or ASD having challenges in both communication and social interaction. This study intends to find the contributing factors that lead to ASD in the Philippines. The dataset has been collected by interviewing 400 pregnant women in Metro Manila, Philippines. Further, it has been divided into prenatal, natal, and postnatal period categories. Thereafter, various machine learning algorithms such as Linear Regression, Bayesian Ridge, Ridge Regression, Least Angle Regression, and Gradient Boosting Regressor are applied to identify the risk factors that are contributing to ASD. Linear Regression and Bayesian Regression show exceptional performance. This study has implications to practical implications towards further understanding the how technology can arrest the negative effects of ASD.
Engineering and evaluation of thermostable IsPETase variants for PET degradation

Polyethylene terephthalate (PET) is a mass‐produced petroleum‐based synthetic polymer. Enzymatic PET degradation using, for example, Ideonella sakaiensis PETase (IsPETase) can be a more environmentally friendly and energy‐saving alternative to the chemical recycling of PET. However, IsPETase is a mesophilic enzyme with an optimal reaction temperature lower than the glass transition temperature (Tg) of PET, where the amorphous polymers can be readily accessed for enzymatic breakdown. In this study, we used error‐prone PCR to generate a mutant library based on a thermostable triple mutant (TM) of IsPETase. The library was screened against the commercially available polyester‐polyurethane Impranil DLN W 50 for more thermostable IsPETase variants, yielding four variants with higher melting points. The most promising IsPETaseTMK95N/F201I variant had a 5.0°C higher melting point than IsPETaseTM. Although this variant showed a slightly lower activity on PET at lower incubation temperatures, its increased thermostability makes it a more active PET hydrolase at higher reaction temperatures up to 60°C. Several other variants were compared and combined with selected previously published IsPETase mutants in terms of thermostability and hydrolytic activity against PET nanoparticles and amorphous PET films. Our findings indicate that thermostability is one of the most important characteristics of an effective PET hydrolase.
Clusters for life or life cycles of clusters: in search of the critical factors of clusters' resilience

This article investigates the driving forces behind the life cycles and resilience of technological clusters. It concentrates, in particular, on the combination of critical parameters which allows clusters to succeed in disconnecting their cycle from the cycle of the technologies they produce, in order to maintain stability and growth in unstable economic environments. Three propositions on location decision externalities, the life cycle of composite technologies and the structural properties of knowledge networks are developed and introduced in an inclusive study of cluster trajectories. Discussions show that resilient clusters are those that combine network and external audience effects in location decision-making and evolve towards a specific core/periphery and disassortative structure of knowledge interactions along the knowledge and market phases. Understanding these pathways could be at the heart of the renewal of cluster and regional policy in a macro-economic context characterized by high instability and new growing consumer paradigms.
Hypomorphism of a novel long ERα isoform causes severe reproductive dysfunctions in female mice

Estrogen receptor alpha (ERα)-mediated estrogen signaling play a pivotal role in both reproductive and non-reproductive functions. Transcriptional regulation of ERα gene is highly complex, with multiple transcript variants being differentially produced across the tissues. However, tissue-specific variation and physiological specificity of the ERα variants are not yet fully understood. In an attempt to generate a Cre-dependently restorable ERα-null mice for functional investigation of the genetic sufficiency, we unexpectedly produced ERα hypomorphic mice with biased downregulation of a previously unappreciated long ERα isoform that is enriched in the female reproductive organs (uterus and ovaries) and the pituitary but minimally expressed in the brain. Female homozygous mutant mice were capable of pregnancy but displayed irregular estrus cycle and rarely maintained alive newborns without significant morphological and pathological changes in reproductive system and the disruption of body weight homeostasis, indicating the vital role of this long isoform in female reproductive function. Collectively, our results define a tissue-specifically enriched long ERα isoform and its preferential role in female reproductive function over body weight homeostasis.
Chemical inhibition of prolyl hydroxylases impairs angiogenic competence of human vascular endothelium through metabolic reprogramming

Endothelial cell (EC) metabolism has emerged as a driver of angiogenesis. While hypoxia inactivates prolyl-4 hydroxylase domain containing proteins 1-3 (PHD1-3) and stabilizes hypoxia inducible factors (HIFs) stimulating angiogenesis, the effects of PHDs on EC functions remain unclear. Here, we investigated the impact of PHD inhibition by dimethyloxalylglycine (DMOG) on angiogenic competence and metabolism of human vascular ECs. PHD inhibition reduced EC proliferation, migration, and tube formation capacities. Furthermore, transcriptomic and metabolomic analyses revealed an unfavorable metabolic reprogramming for angiogenesis following treatment with DMOG. Despite the induction of glycolytic genes and high levels of lactate, multiple genes encoding sub-units of mitochondrial complex I were suppressed with concurrent decline in nicotinamide adenine dinucleotide (NAD+) levels. Importantly, defective EC migration due to DMOG could be partially restored by augmenting NAD+ levels. Combined, our data provide metabolic insights into the mechanism by which chemical PHD inhibition impairs angiogenic competence of human vascular ECs.
Reciprocity and interaction effectiveness in generalised mutualisms among free‐living species

Mutualistic interactions among free-living species generally involve weak links and highly asymmetric dependence among partners, yet our understanding of factors beyond their emergence is still limited. Using individual-based interactions of a super-generalist fleshy-fruited plant with its frugivore assemblage we estimate the Resource Provisioning Effectiveness (RPE) and Seed Dispersal Effectiveness (SDE) to assess the balance in the exchange of resources. Plants were highly dependent on a few super-generalist frugivore species, while these interacted with most individual plants, resulting in strong asymmetries in mutual dependence. Both RPE and SDE were mainly driven by interaction frequency. Despite highly asymmetric dependences, the strong reliance on quantity largely determined high reciprocity in rewards between partners (i.e., higher energy provided, more seedlings recruited), not obscured by minor variations in the quality of animal or plant service. We anticipate reciprocity will emerge in low-intimacy mutualisms where the mutualistic outcome largely relies upon interaction frequency.
Factors Influencing Faculty Members’ Learning Management Systems Adoption Behavior: An Analysis Using The Technology Acceptance Model

Faculty members underutilize the Learning Management System (LMS), a web-based based technology intended to facilitate student learning, despite the ubiquitous presence of the system at many universities. Drawing from Davis’s (1989) Technology Acceptance Model (TAM), this study identifies how faculty attitudes toward the LMS impact their adoption of this technology. The study focuses on a specific LMS, Blackboard. Thirty-six faculty members were invited to complete a web-based survey. Directive content analysis was utilized to analyze and interpret the survey responses. The study reveals that specific challenges including system problems and design flaws reduce the overall utilization of the LMS by faculty. Recommendations about how to increase the utilization of Blackboard among faculty members are included.
The attitudes of students towards the use of ICT during their studies

The purpose of this study was to examine attitudes of students towards the use of ICT during their studies. The survey included 285 students from Girne American University, Turkey. The sample consists of the students from first to fourth grade. The scale consists of 45 claims and is intended for determining students’ attitudes towards the use of ICT during their studies. Questionnaires were utilized to gather information on the attitudes of students towards the use of ICT during their studies. Information was broke down using SPSS statistical package (IBM SPS Statistics Version 20) and with Monte Carlo program for the parallel examination. The study established that students towards the utilization of ICT made the significant commitment to the students' academic performance. It is advanced that the discoveries of this study will be valuable to students to acquire knowledge into the ICT variables that influence students' scholastic execution and consequently enhance their academic performance.Results indicate that after one year of the intervention, there were statistically significant differences between the two groups only in sight vocabulary (at kindergarten and grade 1) and in alphabet (kindergarten). In all other areas of language development, there were no statistically significant differences between the achievement scores of the two groups. Results show that students appear to react to the prerequisites of their courses, programs, and universities. In all cases, there is a reasonable relationship between the students' view of handiness on certain ICT assets the critical quantities of understudies are quick to see ICT misused in the educating and learning process. There is positively scope for further research to examine how ICT interfaces crosswise over various areas and how the cross-connection application impacts its utilization.
Performance of some Safflower (Carthamus tinctorius L.) Varieties Sown in Late-autumn and Late-spring

This study was conducted to evaluate the effects of late-spring and late-autumn sowing times on oil content, seed yield and some yield components of three safflower (Carthamus tinctorius L.) varieties at Field Crops Department, Agricultural Faculty of Ankara University. Yenice, Dincer and Remzibey-05 safflower varieties were sown on 19 November 2004 and 20 May 2005. According to results of this research; plant height 111.47 and 59.93 cm, capitula number per plant 15.57 and 8.58, secondary branch number per plant 6.26 and 5.07, seed number per capitula 30.18 and 28.67, a thousand seed weight 35.62 and 38.24 g, seed yield 200.74 and 112.30 kg/da, harvest index 30.09 and 30.46 %, oil content 26.75 and 22.14 % and oil yield 53.87 kg/da and 23.03 kg/da were recorded in late-autumn and late-spring sowing, respectively. The highest seed yield and, oil content and yield were obtained from cv. Dincer and cv. Dincer and cv. Remzibey-05, respectively. The effect of late-autumn sowing on plant height, capitula number, secondary branch number, seed yield, oil content and oil yield were positive and significant statistically. The increasing ratio of these characters in late-autumn sowing according to late-spring sowing was 86.14%, 81.38%, 5.68%, 80.00% , 21.03% and 119.10%, respectively.
Advantages of Sentinel Lymph Node Mapping by Single Photon Emission Computed Tomography/Computed Tomography in Early-Stage Malignant Head-and-Neck Skin Tumors

Background: The aim of this study was to determine the advantages of preoperative sentinel lymph node mapping (SLNM) by single photon emission computed tomography/computed tomography (SPECT / CT) in patients with early-stage cutaneous head-and-neck malignancies. Materials and Methods: We conduct a 7-year and 6 months retrospective, cross-sectional study. Patients with early-stage malignant head-and-neck skin tumors and cutaneous adnexa who underwent SLNM by SPECT/CT from March 2012 and December 2019, were included in the study. Results: We retrospectively analyzed 28 patients: Melanoma was the most frequent tumor (64.2%), followed by squamous cell carcinoma (25%). The anterior cheek was the most common functional subsite (25%). Twenty-seven patients (96.4%) had a successful SLN detection with SPECT/CT. Neck lymph node dissection was performed in 23 patients (82.1%). According to the pathological specimen, lymph nodes were found in all of them; hence, the efficacy of the SPECT/CT for SLNM was 100%. At 7-year follow-up, systemic recurrence was found in one patient (3.6%), another had locoregional recurrence (3.6%), and the mortality rate was 3.6%. Conclusions: In early-stage malignant head-and-neck skin tumors, there is a high concordance between SLN found by SPECT/CT and the histopathological results. Preoperative SPECT/CT accurately detects the SLN, assesses unexpected lymph nodes and their drainage pathways, and facilitates their location by reliably showing the relationships between sentinel nodes and important anatomic structures. This allows to perform a clear preoperative evaluation, an accurate staging for all patients and to avoid excessive dissections that could result in cosmetic and functional deformities.
Outcomes in Temporary ICUs Versus Conventional ICUs: An Observational Cohort of Mechanically Ventilated Patients With COVID-19–Induced Acute Respiratory Distress Syndrome

IMPORTANCE: Throughout the COVID-19 pandemic, thousands of temporary ICUs have been established worldwide. The outcomes and management of mechanically ventilated patients in these areas remain unknown. OBJECTIVES: To investigate mortality and management of mechanically ventilated patients in temporary ICUs. DESIGN, SETTING, AND PARTICIPANTS: Observational cohort study in a single-institution academic center. We included all adult patients with severe COVID-19 hospitalized in temporary and conventional ICUs for invasive mechanical ventilation due to acute respiratory distress syndrome from March 23, 2020, to April 5, 2021. MAIN OUTCOMES AND MEASURES: To determine if management in temporary ICUs increased 30-day in-hospital mortality compared with conventional ICUs. Ventilator-free days, ICU-free days (both at 28 d), hospital length of stay, and ICU readmission were also assessed. RESULTS: We included 776 patients (326 conventional and 450 temporary ICUs). Thirty-day in-hospital unadjusted mortality (28.8% conventional vs 36.0% temporary, log-rank test p = 0.023) was higher in temporary ICUs. After controlling for potential confounders, hospitalization in temporary ICUs was an independent risk factor associated with mortality (hazard ratio, 1.4; CI, 1.06–1.83; p = 0.016). There were no differences in ICU-free days at 28 days (6; IQR, 0–16 vs 2; IQR, 0–15; p = 0.5) or ventilator-free days at 28 days (8; IQR, 0–16 vs 5; IQR, 0–15; p = 0.6). We observed higher reintubation (18% vs 12%; p = 0.029) and readmission (5% vs 1.6%; p = 0.004) rates in conventional ICUs despite higher use of postextubation noninvasive mechanical ventilation (13% vs 8%; p = 0.025). Use of lung-protective ventilation (87% vs 85%; p = 0.5), prone positioning (76% vs 79%; p = 0.4), neuromuscular blockade (96% vs 98%; p = 0.4), and COVID-19 pharmacologic treatment was similar. CONCLUSIONS AND RELEVANCE: We observed a higher 30-day in-hospital mortality in temporary ICUs. Although both areas had high adherence to evidence-based management, hospitalization in temporary ICUs was an independent risk factor associated with mortality.
Post immunization COVID-19 disease

One hundred and two patients reported to peripheral hospital, of these 73 (77%) and 23 (95%) suffered from COVID-19 disease, were immunized as per availability of Covishield 78 (77%) and Covaxin 24 (23%), respectively. Of these, three died (3%). Inflammatory markers were raised in Covishield vs. Covaxin 26 (36%) vs. 7 (31%), 46 (63%) vs. 8 (35%), 57 (78%) vs. 14 (61%), 29 (40%) vs. (73%), C-reactive proteins and serum ferritin, and positive for COVID-19 antigen and RTPCR and COVID-19 pneumonia, respectively. Irrespective of immunization status of victim with symptoms should be investigated for possibility of severe acute respiratory syndrome COVID-beta 2 (SARS-CoV-2) virus infection. These findings confirmed the need for a Booster dose of COVID-19 vaccination.
Perceptions and attitudes toward unusual complications following breast implant surgeries among Saudi female patients: How knowledgeable are our patients?

Background: The number of breast implant-related procedures has rapidly increased. Given the current increase in social media coverage and its influence on the decision to undergo breast implant surgeries, it is critical to identify patients' misinformation about unusual complications related to breast implants. Therefore, the present study aimed to assess the perceptions and attitudes toward unusual complications related to breast implants among patients who underwent breast implant surgeries. Methods: In the present cross-sectional study, a questionnaire was distributed between April 2021 and May 2021 among patients who had undergone breast implant surgeries between 2016 and 2021 at King Saud University Medical City in Riyadh, Saudi Arabia. The 26-item questionnaire was distributed online to assess the participants' perceptions about breast implant illness (BII), capsular contracture, and breast implant-associated anaplastic large-cell lymphoma (BIA-ALCL). Data were analyzed using Statistical Package for the Social Sciences (SPSS), version 23.0. Results: In total, 106 patients who underwent breast implant surgeries were included in the present study (response rate: 73.6%). Their mean age was 43.68 ± 10.69 years. The reason for undergoing breast implant surgery was cosmetic in 41.5% of the participants and reconstructive in 58.5%. Moreover, 22.6%, 23.6%, and 24.5% of the participants had knowledge about BIA-ALCL, BII, and capsular contracture, respectively. Conclusions: The present findings indicate that it is important for plastic surgeons to discuss unusual complications related to breast implants with patients on a regular basis. Despite the obscurity of these complications, such discussions are important to provide best available information to patients.
Different diets and their effect on tuberculosis prevention in HIV patients

Introduction: The relationship between nutrition and human immunodeficiency virus (HIV) infection, tuberculosis, and other infectious diseases is logically proven. Nutrition affects the immune system and the health of the organs. Inadequate dietary intake endangers the immune system, which itself increases susceptibility to disease and often culminates in active disease. The disease then reduces the body's appetite and ability to absorb nutrients, and the cycle continues. Considering the importance of the role of nutrition in the health of acquired immune deficiency syndrome (AIDS) patients, this current review aimed to discuss the different diets and their effects on tuberculosis (TB) prevention in HIV patients. Method and Materials: The present study evaluates the important points related to AIDS and the prevention and treatment of this disease by considering the diet and known scientific cases during the last 10 years, in simple terms, the prevalence of this disease. Result: Articles were searched by valid databases in May 2021. The findings showed that in addition to malnutrition, the high prevalence of infectious diseases can have serious consequences for public health. Many people will be safe from getting infections if there are safe and effective interventions for many of these infectious diseases. Conclusion: Based on the information presented herein, it is clear that TB affects the nutritional status. Many patients with active TB experience severe weight loss, and many people with the symptoms show a lack of vitamins and minerals.
Medical and nonmedical use of psychiatric medications among medical students in Riyadh, Saudi Arabia

Introduction: Psychiatric medication use has increased recently among college students. This includes antidepressants, opioids, stimulants, analgesics, sedatives, and anxiolytics, which could be self-administered without medical supervision. Objectives: To determine the prevalence of medical and nonmedical use of psychiatric prescription medications and its correlation with academic performance, demographic data as well as the motives for the nonmedical use. Methods: A cross-sectional study aims to assess the psychiatric medication use with or without prescription with the motives behind it, and demographic data of the students at medical colleges in Riyadh, Saudi Arabia. Results: A total of 1268 responded to the questionnaire. 251 (20%) of the participants reported using some psychiatric medications in their lifetime, while 191 (15%) participants used some psychiatric medications in the last 12 months. Antidepressants were most used in the surveyed population 144 (57%), followed by opioids/pain relief medications 62 (24%) and anxiolytics 39 (15%). Only 44 surveyed students (3.5%) reported nonmedical use of these psychiatric medications. As for the motives of nonmedical use, the greatest portion reported to use it for “relax or relieve tension” 12 (29%), followed by “relieve pain caused by other health problems” 8 (20%), and “medication to get through the day” 6 (15%). Conclusion: Nonmedical use of psychiatric medications among medical students in Riyadh is several times lower than reports by other researchers. Future research should focus on collecting more participants who are using medications without prescription and conduct cross-cultural studies to examine factors contributing to such low rates of illicit psychiatric medication use.