Miracle-dz/UniFAR-FTUs huggingface dataset:
Numerical Assessment of Downward Incoming Solar Irradiance in Smoke Influenced Regions - A Case Study in Brazilian Amazon and Cerrado

Smoke aerosol plumes generated during the biomass burning season in Brazil suffer long-range transport, resulting in large aerosol optical depths over an extensive domain. As a consequence, downward surface solar irradiance, and in particular the direct component, can be significantly reduced. Accurate solar energy assessments considering the radiative contribution of biomass burning aerosols are required to support Brazil’s solar power sector. This work presents the 2nd generation of the radiative transfer model BRASIL-SR, developed to improve the aerosol representation and reduce the uncertainties in surface solar irradiance estimates in cloudless hazy conditions and clean conditions. Two numerical experiments allowed to assess the model’s skill using observational or regional MERRA-2 reanalysis AOD data in a region frequently affected by smoke. Four ground measurement sites provided data for the model output validation. Results for DNI obtained using δ-Eddington scaling and without scaling are compared, with the latter presenting the best skill in all sites and for both experiments. An increase in the relative error of DNI results obtained with δ-Eddington optical depth scaling as AOD increases is evidenced. For DNI, MBD deviations ranged from −2.3 to −0.5%, RMSD between 2.3 and 4.7% and OVER between 0 and 5.3% when using in-situ AOD data. Overall, our results indicate a good skill of BRASIL-SR for the estimation of both GHI and DNI.
Determinants of Nanomedicine Performance for the Treatment of Solid Tumors: Whole Tumor and Intratumoral Assessment of Liposome Distribution

The treatment and diagnosis of cancer have advanced with the use of novel formulation strategies for the delivery of chemotherapy and contrast agents for imaging applications. Nanoparticles, in particular, have emerged as a viable modality in the management of cancer, enabling a reduction in chemotherapy-associated toxicities. The ability to label and image nanoparticles further enables a longitudinal assessment of their performance in vivo and at the tumor site. Owing to the unique pathophysiology of tumors, an enhanced tumor accumulation of nanoparticles relative to conventional chemotherapeutic agents has long been a hallmark of nanoparticle-based therapy. However, significant challenges hamper the potential of existing nanomedicines and, in particular, the clinical translation of emerging candidates. Namely, poor tumor penetration and bioavailability of drug at the tumor site may limit the potency of nanomedicines. Furthermore, heterogeneity in the intratumoral distribution of nanomedicines, as well as that of tumor characteristics, challenge conventional paradigms and practices in the development of nanoparticle-based technologies.
The Tax Cuts and Jobs Act: Searching for Supply-Side Effects

The Tax Cuts and Jobs Act of 2017 (TCJA) instituted the most substantial changes in taxation in decades and was designed to boost the economy via supply-side incentives. This paper reviews these changes and examines the impacts on economic aggregates through 2019. The act clearly reduced revenue. The effect on gross domestic product is difficult to tease out of the data. Investment growth rose after the TCJA was enacted, but it was driven by trends in aggregate demand, oil prices, and intellectual capital that were unrelated to the TCJA’s supply-side incentives. Growth in business formation, employment, and median wages slowed after the TCJA was enacted. International profit shifting fell only slightly, and the boost in repatriated profits primarily led to increased share repurchases rather than new investment.
Efficient Uncertainty Quantification and Exploration for Reinforcement Learning

Yi Zhu Department of Industrial Engineering and Management Sciences, Northwestern University, Evanston, IL 60208, yizhu2020@u.northwestern. edu Jing Dong Division, Risk and Operations Division, Columbia Business School, New York, NY 10027, jing.dong@gsb.columbia.edu Henry Lam Department of Industrial Engineering and Operations Research, Columbia University, New York, NY 10027, henry.lam@columbia.edu
Impact of environmental management system implementation on financial performance: A comparison of two corporate strategies

Environmental management systems (EMS) seek to make companies simultaneously more competitive and environmentally responsible. Improved environmental performance can be sought from the adaptation of techniques that emphasize reduction of waste and process/product redesign in the quest of reducing environmental impact. However, EMS lacks a framework to quantify improvements and much of the evidence of EMS's impact on financial performance is anecdotal. This lack of theoretical development has served to diminish corporate support, thus reducing the likelihood of EMS implementation due to a perceived cost disadvantage. This paper proposes, and tests, a framework to quantify EMS improvements to determine the impact of EMS strategies on financial performance. Our findings suggest that implementation of an EMS strategy does not negatively impact a firm's financial performance.
Analysis of hollow conducting waveguides using superquadric functions-A unified representation

Waveguides of various geometries have found many applications. The analysis of the wave modes inside these waveguides are usually subject to cross sections of the waveguides and specific, but convenient, coordinate systems have to be chosen in the analysis. In this paper, the boundary geometries of waveguides (which include rectangular, circular, elliptical, triangular, coaxial, etc.) are represented in a unified manner by a superquadric function. In this paper, with the Rayleigh-Ritz method, the wave propagation characteristics in a hollow conducting waveguide of the superquadric cross section are analyzed in a unified manner. From the analysis, it is realized that the superquadric function can be utilized to accurately model the boundary of various waveguide structures through variation of the shape parameters. The comparisons between the analytical and computational results show this method is accurate and efficient.
Influence of the Use of a Collagen Membrane Placed on the Bone Window after Sinus Floor Augmentation—An Experimental Study in Rabbits

Background: We studied the influence on healing of a resorbable membrane covering the osteotomy site after maxillary sinus grafting, evaluated in different regions of the augmented area. Methods: Maxillary sinus augmentation was performed in 24 New Zealand rabbits. Osteotomy, 4 × 6 mm, were performed bilaterally. A collagenated cortico-cancellous porcine bone was used to fill the elevated region. A collagen membrane was randomly placed over the osteotomy site on one side (MG), and the other side was left uncovered (NMG). The animals were euthanized after 2, 4, and 8 weeks; and histomorphometric analysis was performed in eight different regions. Results: New bone percentages were similar in both groups. There were no statistically significant differences. In MG, the overall percentages were 15.6 ± 7.3%, 22.9 ± 6.1%, and 24.9 ± 12.0% after 2, 4, and 8 weeks, respectively. In NMG, the percentages were 11.2 ± 4.5%, 24.1 ± 5.7%, and 24.5 ± 15.7%, respectively. The proportions of new bone in the various regions after 8 weeks were 31 ± 8.9% and 29.9 ± 9.1% in the bone walls region, 25 ± 10.1% and 32.8 ± 9.1% in the submucosa region, 22.6 ± 21.6% and 10.9 ± 11.5 in the middle region, 17.3 ± 14% and 13.4 ± 9.8% in the close-to-window region, and 21.8 ± 11.6%, 19.1 ± 6.4% in the osteotomy region—for MG and NMG, respectively. Conclusions: In both groups the greatest amounts of bone formation occurred near to the pre-existing bone walls, followed by the sub-mucosa region. The smallest amounts were found in the close-to-window region, followed by the central region. The placement of a collagen membrane to cover the osteotomy site did not influence the amount of new bone formation after sinus grafting.
Road Vehicle Following System With Adaptive Controller Gain Using Model Reference Adaptive Control Method

In order to maintain stability and satisfy operating constraints, the control system on the following vehicle needs information about the motion of preceding vehicle. A one-vehicle look-ahead control strategy is proposed and will be investigated for this operation. A mathematical model for this control strategy is obtained and simulated. This paper describes the process of designing an adaptive controller gain for a road vehicle following system. This is done through simulations and is further discussed to find the effectiveness of the method.
Relationship between Sea Surface Drag Coefficient and Wave State

The sea surface drag coefficient plays an important role in momentum transmission between the atmosphere and the ocean, which is affected by ocean waves. The total air–sea momentum flux consists of effective momentum flux and sea spray momentum flux. Sea spray momentum flux involves sea surface drag, which is largely affected by the ocean wave state. Under strong winds, the sea surface drag coefficient (CD) does not increase linearly with the increasing wind speed, namely, the increase of CD is inhibited by strong winds. In this study, a sea surface drag coefficient is constructed that can be applied to the calculation of the air–sea momentum flux under high wind speed. The sea surface drag coefficient also considers the influence of wave state and sea spray droplets generated by wave breaking. Specially, the wave-dependent sea spray generation function is employed to calculate sea spray momentum flux. This facilitates the analysis not only on the sensitivity of the sea spray momentum flux to wave age, but also on the effect of wave state on the effective CD (CD, eff) under strong winds. Our results indicate that wave age plays an important role in determining CD. When the wave age is >0.4, CD decreases with the wave age. However, when the wave age is ≤0.4, CD increases with the wave age at low and moderate wind speeds but tends to decrease with the wave age at high wind speeds.
Cognitive and Behavior Deficits in Parkinson’s Disease with Alteration of FDG-PET Irrespective of Age

Significant progress has been made in our understanding of the neurobiology of Parkinson’s disease (PD). Post-mortem studies are an important step and could help to comprehend not only the progression of motor symptoms, but also the involvement of other clinical domains, including cognition, behavior and impulse control disorders (ICDs). The correlation of neuropathological extension of the disease with the clinical stages remains challenging. Molecular imaging, including positron emission tomography (PET) and single photon computed tomography (SPECT), could allow for bridging the gap by providing in vivo evidence of disease extension. In the last decade, we have observed a plethora of reports describing improvements in the sensitivity of neuroimaging techniques. These data contribute to increasing the accuracy of PD diagnosis, differentiating PD from other causes of parkinsonism and also obtaining a surrogate marker of disease progression. FDG-PET has been used to measure cerebral metabolic rates of glucose, a proxy for neuronal activity, in PD. Many studies have shown that this technique could be used in early PD, where reduced metabolic activity correlates with disease progression and could predict histopathological diagnosis. The aim of this work is to report two particular cases of PD in which the assessment of brain metabolic activity (from FDG-PET) has been combined with clinical aspects of non-motor symptoms. Integration of information on neuropsychological and metabolic imaging allows us to improve the treatment of PD patients irrespective of age.
AGTR1 Inhibits the Progression of Lung Adenocarcinoma

Purpose The occurrence and development of lung adenocarcinoma (LUAD) are related to many factors. Multiple researches showed that the renin-angiotensin system (RAS) plays an important role in lung cancer. This research mainly focuses on angiotensin II receptor 1 (AT1R) encoding gene AGTR1, an important part of the RAS. Methods We comprehensively evaluated the expression of AGTR1 in pan-cancer based on RNA sequencing data obtained from The Cancer Genome Atlas (TCGA). We explored the correlation of AGTR1 with clinicopathological features, prognosis and tumor microenvironment in LUAD. We also explored the mechanism through enrichment analysis and verified it with cell lines and tissue samples. Results We found that AGTR1 was less expressed in most tumors and related to prognosis based on the TCGA database. To further explore its mechanism, we mainly focused on LUAD. Combined with the verification results in the GEO database, AGTR1 was associated with a better prognosis in LUAD. High expression of AGTR1 was associated with less lymph node metastasis (P=0.007) and MET mutation (P=0.019). High expression of AGTR1 was related to the anti-tumor immune microenvironment with high infiltration of B cells, myeloid dendritic cells, monocytes, and low infiltration of myeloid-derived suppressor cells (all P<0.05). Enrichment analysis and in vitro verification results showed that AGTR1 was likely to play a role in LUAD through the PI3K/AKT3 pathway. Finally, we verified the above results through tissue samples and the construction of AGTR1 overexpressing cells. Conclusion AGTR1 inhibits the progression of lung adenocarcinoma through the PI3K/AKT3 pathway.
Glypican-1 drives unconventional secretion of fibroblast growth factor 2

Fibroblast Growth Factor 2 (FGF2) is a tumor cell survival factor that is transported into the extracellular space by an unconventional secretory mechanism. Cell surface heparan sulfate proteoglycans are known to play an essential role in this process. Unexpectedly, we found that among the diverse sub-classes consisting of syndecans, perlecans, glypicans and others, Glypican-1 (GPC1) is both the principle and rate-limiting factor that drives unconventional secretion of FGF2. By contrast, we demonstrate GPC1 to be dispensable for FGF2 signaling into cells. We provide first insights into the structural basis for GPC1-dependent FGF2 secretion, identifying disaccharides with N-linked sulfate groups to be enriched in the heparan sulfate chains of GPC1 to which FGF2 binds with high affinity. Our findings have broad implications for the role of GPC1 as a key molecule in tumor progression.
Adopting Measures to Increase Alumni Donations at Prestigious Universities

This research uniquely aims to identify the key factors that current students at prestigious universities indicate have influence upon their likelihood of making donations to their alma mater in the future. Using data and examples from both the UK and the USA we show the importance of voluntary donations to prestigious universities and suggest that UK universities have much to learn from their American counterparts. A novel questionnaire was administered to students studying at a number of prestigious UK universities which resulted in a large number of responses being accepted for inferential statistical analysis. The robust results provide new insight into the significance of student centred pedagogy and students' career and financial aspirations as major determinants of intention to donate and also confirm the importance of overall student satisfaction, acquisition of transferable skills and the social experiences of university as additional determining factors. It is intended that this research should have practical implications and so we emphasise elements of the student and pedagogical experience upon which universities and alumni departments should focus their resources in order to increase the likelihood of obtaining future alumni donations from their current students.
The abiotic and biotic environment together predict plant, mammal, and bird diversity and turnover across the United States

The distribution of taxonomic, phylogenetic, and functional biodiversity results from a combination of abiotic and biotic drivers which are scale dependent. Parsing the relative influence of these drivers is critical to understanding the processes underlying species assembly and generating predictions of biodiversity across taxonomic groups and for novel sites. However, doing so requires data that capture a spatial extent large enough to reflect broad-scale dynamics such as speciation and biogeography, and a spatial grain fine enough to detect local-scale dynamics like environmental filtering and biotic interactions. We used species inventories of vascular plants, birds, and mammals collected by the U.S. National Ecological Observatory Network (NEON) at 38 terrestrial field sites, to explore the processes underlying taxonomic, phylogenetic, and functional diversity and turnover. We found that, for both species richness (alpha-diversity) and turnover (beta-diversity), taxonomic, phylogenetic, and functional diversity are weak proxies for one-another, and thus may capture different species assembly processes. All diversity metrics were best predicted by a combination of abiotic and biotic variables. Taxonomic and phylogenetic richness tended to be higher at warmer, wetter sites, reflecting the role energy inputs play in driving broad-scale diversity. However, plant diversity was negatively correlated with bird phylogenetic and mammal functional diversity, implying trait conservation in plant communities may limit niche availability for consumer species. Equally, turnover in bird and mammal species across sites were associated with plant turnover. That the biodiversity of one taxon is predictive of another across these North American sites, even when controlling for environment, supports a role for the cross-clade biotic environment in driving species assembly.
Biophysical and Architectural Mechanisms of Subthalamic Theta under Response Conflict

The cortico-basal ganglia circuit is needed to suppress prepotent actions and to facilitate controlled behavior. Under conditions of response conflict, the frontal cortex and subthalamic nucleus (STN) exhibit increased spiking and theta band power, which are linked to adaptive regulation of behavioral output. The electrophysiological mechanisms underlying these neural signatures of impulse control remain poorly understood. To address this lacuna, we constructed a novel large-scale, biophysically principled model of the subthalamopallidal (STN-globus pallidus externus) network and examined the mechanisms that modulate theta power and spiking in response to cortical input. Simulations confirmed that theta power does not emerge from intrinsic network dynamics but is robustly elicited in response to cortical input as burst events representing action selection dynamics. Rhythmic burst events of multiple cortical populations, representing a state of conflict where cortical motor plans vacillate in the theta range, led to prolonged STN theta and increased spiking, consistent with empirical literature. Notably, theta band signaling required NMDA, but not AMPA, currents, which were in turn related to a triphasic STN response characterized by spiking, silence, and bursting periods. Finally, theta band resonance was also strongly modulated by architectural connectivity, with maximal theta arising when multiple cortical populations project to individual STN “conflict detector” units because of an NMDA-dependent supralinear response. Our results provide insights into the biophysical principles and architectural constraints that give rise to STN dynamics during response conflict, and how their disruption can lead to impulsivity and compulsivity. SIGNIFICANCE STATEMENT The subthalamic nucleus exhibits theta band power modulation related to cognitive control over motor actions during conditions of response conflict. However, the mechanisms of such dynamics are not understood. Here we developed a novel biophysically detailed and data-constrained large-scale model of the subthalamopallidal network, and examined the impacts of cellular and network architectural properties that give rise to theta dynamics. Our investigations implicate an important role for NMDA receptors and cortico-subthalamic nucleus topographical connectivities in theta power modulation.
Health-Related Quality of Life following Cytoreductive Radical Prostatectomy in Patients with De-Novo Oligometastatic Prostate Cancer

Simple Summary Recent retrospective data indicate a survival benefit of surgical removal of the prostate in patients with oligometastatic prostate cancer as part of a multimodal therapeutic regime. However, the impact of radical prostatectomy (RP) on patient’s health-related quality of life (HRQOL) in this scenario has not been evaluated yet. In a contemporary and well-balanced cohort, we compared the self-assessed HRQOL of patients with oligometastatic prostate cancer with patients with locally confined prostate cancer two years postoperatively. In multivariate analysis, we found no significant difference in postoperative HRQOL and urinary continence recovery in patients with de-novo oligo-metastatic compared to patients with locally confined prostate cancer. Abstract (1) Background: local treatment of the primary tumor has become a valid therapeutic option in de-novo oligo-metastatic prostate cancer (PC). However, evidence regarding radical prostatectomy (RP) in this setting is still subpar, and the effect of cytoreductive RP on postoperative health-related quality of life (HRQOL) is still unclear. (2) Methods: for the current study, patients with de-novo oligo-metastatic PC (cM1-oligo), defined as ≤5 bone lesions in the preoperative staging, were included, and matched cohorts using the variables age, body-mass index (BMI), and pT-stage were generated. Patient-reported outcome measures (PROMS) were assessed pre- and postoperatively using the validated EORTC-QLQ-C30, IIEF-5, and ICIQ-SF questionnaires. The primary endpoint for univariate and multivariable analysis was good general HRQOL defined by previously validated cut-off values. (3) Results: in total, 1268 patients (n = 84 (7%) cM1-oligo) underwent RP between 2012 and 2020 at one tertiary care center. A matched cohort of 411 patients (n = 79 with oligo-metastatic bone disease (cM1-oligo) and n = 332 patients without clinical indication of metastatic disease (cM0)) was created. The median follow-up was 25mo. There was no significant difference in good general HRQOL rates between cM1-oligo-patients and cM0-patients before RP (45.6% vs. 55.2%, p = 0.186), and at time of follow-up (44% vs. 56%, p = 0.811). Global health status (GHS) worsened significantly in cM0-patients compared to baseline (−5, p = 0.001), whereas GHS did not change significantly in cM1-oligo-patients (+3.2, p = 0.381). In multivariate analysis stratified for good erectile function (IIEF5 > 18; OR 5.722, 95% CI 1.89–17.36, p = 0.002) and continence recovery (OR 1.671, 95% CI 1.03–2.70, p = 0.036), cM1-oligo was not an independent predictive feature for general HRQOL (OR 0.821, 95% CI 0.44–1.53, p = 0.536). (4) Conclusions: in this large contemporary retrospective analysis, we observed no significant difference in HRQOL in patients with the oligometastatic bone disease after cytoreductive radical prostatectomy, when compared to patients with localized disease at time of surgery.