Miracle-dz/UniFAR-FTUs huggingface dataset:
THE ROMANIAN VERSION OF THE THYROID-RELATED PATIENT-REPORTED OUTCOMES THYPRO AND THYPRO-39. TRANSLATION AND ASSESSMENT OF RELIABILITY AND CROSS-CULTURAL VALIDITY.

Background ThyPRO is a recently developed thyroid-specific quality of life (QoL) questionnaire applicable to patients with benign thyroid disorders(BTD). The aim of the present study was to translate ThyPRO and ThyPRO-39 into Romanian, and to evaluate reliability and cross-cultural validity. Methods Standard methodology for translation and linguistic validation of patient-reported outcomes (PRO) was applied. The questionnaire was completed by 130 patients with benign thyroid diseases seen at Department of Endocrinology in the Emergency County Hospital, Tîrgu Mureş, Romania, between October 2015 and March 2016. Internal reliability of the Romanian version of the ThyPRO (ThyPROro) scales was assessed for multi-item scales using Cronbach's alpha coefficient. An efficient method for testing cross-cultural validity is analysis of differential item functioning (DIF). Uniform DIF between the Romanian and the original Danish sample was investigated using ordinal logistic regression. The translation process proceeded without difficulties, and any disagreements were revised by one of the developers and the language coordinator. Results Internal reliability for ThyPRO was satisfactory. Cronbach`s alpha coefficients for the 13 scales ranged from 0.78 to 0.93 for the ThyPROro and 0.78 to 0.87 for the ThyPROro-39. In the 85-item ThyPRO, nine instances of DIF were found. Most were minor, explaining <3% of the variation in scale score, but DIF in positively worded items were larger, with explained variance (R2's) around 10-15%. Conclusion The ThyPROro questionnaire is ready for assessment of health-related quality of life in Romanian patients with benign thyroid diseases.
Older Adults’ Perspectives on Volunteering in an Activity-Based Social Program for People with Dementia

ABSTRACT This qualitative study explored older adults’ perspectives on volunteering in an activity-based social program for community-dwelling people with dementia (PwD), called Stepping Stones. Individual semi-structured interviews were conducted with eight older adults who had volunteered in the Stepping Stones program. Interpretative phenomenological analysis was used to support in-depth exploration of interviews. Six main themes emerged, including (1) Meaning of volunteering in the program; (2) Benefits of volunteering in the program on themselves; (3) Enjoyment involving satisfaction and social relationships; (4) We are a team; (5) Emotional closeness and relationship; and (6) Volunteers’ other dementia-related experiences and volunteering experiences. The present study found that volunteering in the Stepping Stones program met older volunteers’ desires of helping PwD and in learning about dementia. This desire might be stronger in older adults who were the relatives or friends of PwD. Volunteering in an activity-based social program for community-dwelling PwD also may provide older adults with opportunities to have meaningful social relationships with others while feeling enjoyment and a sense of satisfaction, and may also help older adults have a more positive outlook on and more tolerance for themselves and others when they or their spouses experience memory changes in their daily lives.
INDIKATOR PREDIKTIF IMUNISASI DASAR LENGKAP PADA BAYI DI PUSKESMAS KONANG DAN GEGER KABUPATEN BANGKALAN

Background : Immunization is one of the types of businesses that can provide immunity to the child by putting the vaccine into the body which is to form antibodies to prevent against diseases that can be prevented by immunization include polio, measles, hepatitis B, tetanus, pertussis, diphtheria, pneumonia and meningitis. Objective : The research objective was to formulate indicators of predictive Immunization Basics Complete in Konang and Geger health centers maternal characteristics (education, occupation, family economic status), mother's knowledge, attitudes mother, access to healthcare, schedule posyandu, counseling, family support ,public figure, health workers, as well as the availability of health care facilities. Methode : The research was observational analytic with cross sectional study. The study population was all babies in Konang and Geger District 2015 as 1813 babies. The samples were chosen as 275 infants. Result : The results showed 12 variables studied only 7 variables that can be used as a candidate to proceed to a multivariate analysis that maternal education (p = 0.177), mother knowledge (p = 0.000), the attitude of the mother (p = 0.000), access to health care (p = 0.001), education (p = 0.043), family support (p = 0.000), and support of health workers (p = 0.012). The variable that has become the candidate values (p <0.25). Formula predictive indicators are fully immunized obtained (-4.459+4.602*Family Support (No)+2.834*Attitudes (Poor)+1.438* knowledge (less)). Conclusion : The conclusion of this study is the mother's knowledge, attitudes mother, access to health services, counseling, family support, and the support of health workers is a factor affecting the completeness of basic immunization in infants at Konang and Geger health centers. Keywords: indicators, are fully immunized, the risk factors are fully immunized
Kallikrein Gene Delivery Attenuates Hypertension and Cardiac Hypertrophy and Enhances Renal Function in Goldblatt Hypertensive Rats

Abstract—To demonstrate potential therapeutic effects of kallikrein gene delivery, we delivered adenovirus (Ad.CMV-cHK) carrying the human tissue kallikrein gene into two-kidney, one-clip Goldblatt hypertensive rats. A single intravenous injection of the recombinant adenovirus caused a delay of blood pressure increase that began 1 day after injection and continued for 24 days. A maximal blood pressure reduction was observed in rats receiving kallikrein gene delivery compared with control rats receiving Ad.CMV-LacZ (160±5 versus 186±7 mm Hg, n=6, P<.01). The expression of human tissue kallikrein mRNA was identified in the kidney, heart, aorta, and liver of rats receiving kallikrein gene delivery. Immunoreactive human kallikrein levels were measured in rat serum and urine in a time-dependent manner. Adenovirus-mediated kallikrein gene delivery caused a significant reduction in the left ventricular mass and cardiomyocyte size, as well as an increase in renal blood flow, urine flow, glomerular filtration rate.
PEDIATRIC HOME MECHANICAL VENTILATION: A CANADIAN THORACIC SOCIETY CLINICAL PRACTICE GUIDELINE Section 6: Home ventilation in children with chronic lung diseases

Some children with chronic lung diseases (CLD) may require home mechanical ventilation (HMV). This section will focus on bronchopulmonary dysplasia (BPD) and cystic fibrosis (CF), though other CLDs such as primary ciliary dyskinesia and those that may result in pulmonary hypertension are also addressed. The goals of this section are: (1) to review the literature on the experience in using HMV (invasive and noninvasive) in children with chronic respiratory failure secondary to CLD such as BPD and CF; (2) to review the outcomes of HMV for these populations; (3) to provide Canadian-specific pediatric practice recommendations around long-term home ventilation for children with respiratory failure and hypoventilation secondary to CLD; and (4) to identify areas for further research.
Physical activity and long-term survival in older men and women: A 21 year longitudinal study

ABSTRACT The NLSAA survey was conducted in 1985 with 1,042 participants. As of 31st May 2006 (21 years from baseline), there were 919 recorded deaths (368 men and 551 women). Mortality analyses were from baseline interview to death or censorship (May 2006). Men and women were analysed separately in unadjusted models and adjusting for demographic and health-related variables. In separate unadjusted models, participation in outdoor activities, indoor productive activities, leisure activities, walking, undertaking activities requiring flexibility, and physical effort each were associated with reduced long-term mortality among both men and women. In adjusted models, participation in physical activities had no significant association with mortality risk for men. Among women, participation in outdoor activities and leisure activities remained significantly associated with long-term survival in adjusted models. Among men, the benefits of physical activities for mortality risk were explained through demographic, health, and psychosocial variables. However, participation in outdoor and leisure physical activities was beneficial for women and had a significant association with survival, even when controlling for demographic, health and psychosocial variables. Therefore, encouraging participation in specific physical activities, such as gardening, swimming, and dancing among older women may improve long-term survival.
Anteromedian, Central, and Posterolateral Infarcts of the Thalamus

Background and Purpose— Thalamic infarcts have traditionally been classified into 4 territories: anterior, paramedian, inferolateral, and posterior. The purpose of this study was to review this classical versus variant distribution in patients with thalamic stroke. Methods— We reviewed all patients with a first clinical stroke included in the Lausanne Stroke Registry between 1990 and 2002. Among 71 patients with an acute stroke isolated to the thalamus confirmed by MRI, we selected all patients with lesions outside the classical territories and studied their clinical, etiological, and radiological features. Results— A total of 21 patients (30% of all thalamic stroke patients) showed infarction outside the classical territories, allowing us to delineate 3 variant distributions: (1) Anteromedian territory (9 patients [13%]) involving anterior and paramedian territories, with predominantly cognitive impairment, including executive dysfunction, anterograde amnesia, and aphasia in left-sided or bilateral lesio.
Retrospective Comparison of Moderate and Severe Diaphragmatic Eventration in Children: Efficiency of Radiological Classification

Diaphragmatic eventration (DE) is defined as the elevation of the hemidiaphragm without defects of continuity. The generally accepted concept of its management includes conservative and surgical treatment options for asymptomatic and symptomatic cases respectively. Respiratory symptoms such as pneumonia and dyspnea constitute the common indications for surgical intervention; however, these symptoms do not always correlate with the severity of the pathology and hence the decision for surgery may sometimes be challenging. Thoracoscopic diaphragmatic plication (TDP) has been performed on children for decades and has been shown to be effective and safe previously (1-3). However, no classification or a surgical approach algorithm has been proposed for this anomaly to date. The purpose of this report is to identify the factors for the necessity and the efficiency of TDP in children with DE. Aim: Diaphragmatic eventration (DE) is a congenital or acquired elevation of the hemi-diaphragm. The indications for surgery may be challenging because clinical symptoms do not always correlate with radiological severity. We aim to identify the factors for the necessity and the efficiency of thoracoscopic diaphragmatic plication (TDP) in children with DE. Materials and Methods: A retrospective cross-sectional analysis of patients treated for DE (April 2006-August 2017) was performed. Demographics, type of DE, laterality, associated malformations and clinical symptoms were evaluated. Patients were grouped in two groups (moderate and severe) according to their diaphragmatic elevation levels on X-ray at admission. The severe DE group (SDE, n=14) had a DE of more than 2 vertebral bodies whereas the DE was 2 vertebral bodies or less in the moderate DE group (MDE, n=16). The groups were then compared regarding the necessity of TDP. The efficiency of TDP was analyzed by comparison of the outcome of patients who underwent TDP with that of conservative management. Results: There were 30 DE cases with a median age of 13.75 months. DE was acquired in 5 patients. The right side was the dominant side (21/30). The most common clinical symptoms were pneumonia (21) and respiratory distress (7) while 6 cases were asymptomatic. Acquired DE and respiratory distress were significantly higher in the SDE group. Four patients (25%) in the MDE group and 13 patients (92.9%) in the SDE group required TDP (p=0.000). The total number of cases of pneumonia was significantly higher in the conservatively treated patients in the follow-up (p=0.023). Conclusion: Two vertebral bodies may be an efficient cut-off level to discriminate between MDE and SDE. Absolute indications for TDP are SDE, acquired DE and respiratory distress at admission. Patients that are conservatively treated are more prone to pneumonia.
Comparison of Incidence of Low Back Pain in Women with Normal Vaginal Delivery and Cesarean Section

Objective: To compare the incidence of low back pain between women who underwent caesarean section and those had normal vaginal delivery. Methods: This comparative study was conducted in Dow university hospital from January 2014-December 2017. Total 340 patients coming in Orthopaedics OPD with backache fulfilling the inclusion criteria were enrolled in the study after taking informed consent. Questionnaires were filled by the research team members. Results: Mean age of the respondents was 28 years, with mean parity was 4.2, 170(50%) delivered via normal vaginal delivery, 170(50%) (%) via Caesarean section. 20(5.8) %, out of them got general anesthesia,150 (94.2%) were given regional anesthesia. Out of those 150 who got regional anesthesia,105(70%) got spinal anesthesia and 45(30%)patient got epidural anesthesia. Patients who underwent C-section, 48(28.8%)%) had elective C-section, 122(61.7%%) had emergency C-section. Back pain was started in 15(4.4%) before pregnancy, 50(16.9%) during pregnancy and 266(77.3 %) after delivery. Regarding intensity of pain, 23(6.7 %) respondents mild backache, 175(50.9%) moderate and 140(40.7%) severe backache. Conclusion: Low back pain is a problem in women after delivery either with cesarean section or normal vaginal delivery. There are certain risk factors which are associated with low back ache, those can be avoided needs specific strategies and management plan during pregnancy, at the time of delivery or during the administration of anesthesia
A clinical case study of a psychoanalytic psychotherapy monitored with functional neuroimaging

This case study describes 1 year of the psychoanalytic psychotherapy using clinical data, a standardized instrument of the psychotherapeutic process (Psychotherapy process Q-Set, PQS), and functional neuroimaging (fMRI). A female dysthymic patient with narcissistic traits was assessed at monthly intervals (12 sessions). In the fMRI scans, which took place immediately after therapy hours, the patient looked at pictures of attachment-relevant scenes (from the Adult Attachment Projective Picture System, AAP) divided into two groups: those accompanied by a neutral description, and those accompanied by a description tailored to core conflicts of the patient as assessed in the AAP. Clinically, this patient presented defense mechanisms that influenced the relationship with the therapist and that was characterized by fluctuations of mood that lasted whole days, following a pattern that remained stable during the year of the study. The two modes of functioning associated with the mood shifts strongly affected the interaction with the therapist, whose quality varied accordingly (“easy” and “difficult” hours). The PQS analysis showed the association of “easy” hours with the topic of the involvement in significant relationships and of “difficult hours” with self-distancing, a defensive maneuver common in narcissistic personality structures. In the fMRI data, the modes of functioning visible in the therapy hours were significantly associated with modulation of the signal elicited by personalized attachment-related scenes in the posterior cingulate (p = 0.017 cluster-level, whole-volume corrected). This region has been associated in previous studies to self-distancing from negatively valenced pictures presented during the scan. The present study may provide evidence of the possible involvement of this brain area in spontaneously enacted self-distancing defensive strategies, which may be of relevance in resistant reactions in the course of a psychoanalytic psychotherapy.
Serum values of atherogenic index of plasma and lipid ratios in gestational diabetes mellitus

Introduction: Gestational diabetes mellitus (GDM) can increase the risks for type 2 diabetes, metabolic syndrome and cardiovascular diseases after pregnancy. Lipids are biomarkers that can give valuable information in this aspect. This study was performed with aim to assess serum values of lipids, lipid ratios and atherogenic index of plasma (AIP) and their relationship with maternal age and GDM. Methods: This case-control study was performed on 52 women with GDM and 59 normal pregnant women referred to Asalian hospital of Khorramabad, Iran during 2013-2014. Serum values of cholesterol, total cholesterol (TC), triglyceride (TG), and high-density lipoprotein cholesterol (HDL-C) were measured using commercially available kits and low-density lipoprotein cholesterol (LDL-C) was calculated. Data were analyzed by SPSS software (version 19), and Kolmogorov – Smirnov, Independent t-test, Pearson’s correlation and regression. PResults: Values of TC/HDL-C ratio (P<0.001), LDL-C/HDL-C ratio (P<0.001) and AIP (P<0.001) were significantly increased while values of HDL-C (P<0.001) and HDL ratio (P<0.001) were significantly decreased in GDM group compared with normal pregnancy; the differences remained significant after adjusting for age of the subjects. The results of logistic regression analysis showed that before and after adjusting for age of the subjects, HDL-C and HDL ratio were negative risk factors for GDM and TC/HDL-C ratio, LDL-C/HDL-C ratio and AIP were positive risk factors for GDM. Conclusion: Increased TC/HDL-C ratio, LDL-C/HDL-C ratio, and AIP and decreased HDL-C and HDL ratio could be considered risk factors for GDM. Regularly measurements of lipid ratios and interventions for regulation of them might significantly prevent the prevalence of GDM and caused cardiovascular disease especially at postpartum period. © 2016, Mashhad University of Medical Sciences. All rights reserved.
Excision of traumatic fibroma by diode laser

Irritation fibroma is the most common tumor-like and submucosal reactive lesion in the oral cavity that composed of fibrous or connective tissue causing by traumatic irritants such as calculi, foreign bodies, chronic biting, overhanging margin restoration, sharp spicules of bones, and overextended borders of appliances. It is a well-defined lesion, slow in growth, and can occur in any age group but is more prevalent in the third, fourth, and fifth decades with a female predilection. The tumor may be small or may increase to several centimeters in diameter. The tumor may become irritated and inflamed and sometimes may even show ulcers, which is superficial in nature. The lesions are nonsymptomatic, and the patient usually reports for treatment due to the problem and discomfort during mastication. The fibroma appears as a nodular growth mainly on the buccal mucosa along the occlusal plane. Other common sites are the gingiva, palate, lips, and the tongue. The management of this reactive lesion can be done through conservative surgical approach.
Community College Counselors’ Experiences and Challenges with Postsecondary Students with Mental Health Disorders

Mental health disorders among students are a growing problem in today’s postsecondary institutions. Counselors in many of these institutions are overwhelmed by the increasing demand for their services. This chapter presents findings from a qualitative study that examined the challenges community college counselors face when working with students experiencing mental health disorders. Ten counselors from seven colleges in the province of Alberta in Canada participated in semi-structured individual and telephone interviews that were analyzed thematically. The counselors dealt with a high proportion of minority and ethnically diverse students who experienced multiple barriers to postsecondary study. Two broad themes with several subthemes emerged from the analysis. The two broad themes were (1) challenges for counselors arising from the mind-set of students about their mental health condition and (2) challenges for counselors arising from lack of resources. Implications of these findings for practice and policy are discussed. lot of questions pretty quickly in a way that a student is willing to open up pretty quickly and give us some pretty key information
Habits

troduction of the hypodermic syringe, the enlarged resources of modern pharmacy, and the publicity given to the prevalence of the "habit" in question by various writings, some avowedly of fiction, and others professing to be more or less records of fact, have, no doubt, been to a very large extent responsible for its increase ; but its foundation seems to repose upon a demand which is almost universal among mankind. In every climate, and among every people, experience has taught the lesson that there
A study on effectiveness of lactational amenorrhea as a method of contraception

Background: The lactational amenorrhea method, known as LAM, is part of the World Health Organization’s list of accepted and effective methods of family planning. Studies show LAM to be 98% effective, as effective as the pill and other modern methods, when used according to guidelines. As LAM costs nothing, easy and natural to use, no medication or any devise needed, no interference with natural hormones, no interruption in conjugal life and more over the mother enjoying her motherhood life, it sounds very good as a method of contraception.Methods:This is a prospective non-comparative study. A total of 298 mothers participated in this study. The benefits of exclusive breast feeding with particular emphasis on timely breastfeeding and must feeding during the night hours were explained to the mothers and the physiology of lactational amenorrhea was explained to them. All the mothers were interviewed and followed up on monthly basis. Results:No lactating mothers conceived within the first six months of delivering their baby and only 4% mothers had evidence of pregnancy mainly after the 10th months after delivery.Conclusions:The lactational amenorrhea method is a highly effective method of contraception for 6 months if exclusive breastfeeding practices are followed. In a country like India where use of contraceptive methods are very meager, LAM may prove a boon as it provides dual benefit of exclusive breastfeeding and prevention of pregnancy.