Miracle-dz/UniFAR-FTUs huggingface dataset:
Use of Levosimendan in Patients with Advanced Heart Failure: An Update

Levosimendan is an inodilator drug that, given its unique pharmacological actions and safety profile, represents a viable therapeutic option in patients with heart failure with reduced ejection fraction in the advanced stage of the disease (advHFrEF). Pulsed levosimendan infusion in patients with advHFrEF improves symptoms and clinical and hemodynamic status, prevents recurrent hospitalizations, and enables optimization of guidelines-directed medical therapy. Furthermore, considering its proprieties on right ventricular function and pulmonary circulation, levosimendan could be helpful for the prevention and treatment of the right ventricular dysfunction post-implanting a left ventricular assist device. However, to date, evidence on this issue is scarce and has yielded mixed results. Finally, preliminary experiences indicate that treatment with levosimendan at scheduled intervals may serve as a “bridge to transplant” strategy in patients with advHFrEF. In this review, we summarized the clinical pharmacology of levosimendan, the available evidence in the treatment of patients with advHFrEF, as well as a hypothesis for its use in patients with advanced heart failure with preserved ejection fraction.
Spatial-Temporal Changes and Simulation of Land Use in Metropolitan Areas: A Case of the Zhengzhou Metropolitan Area, China

Metropolitan areas are the main spatial units sustaining development. Investigating internal factor changes in metropolitan areas are of great significance for improving the quality of development in these areas. As an emerging national central city of China, Zhengzhou has experienced rapid urban expansion and urbanization. In this study, principal component analysis and the model and Geodetector model were used to comprehensively analyze the influencing factors of land use change in Zhengzhou from 1980 to 2015. Based on the CA–Markov model, we improved the accuracy of multi-criteria evaluation of suitability factors and simulated land use change in 2015. The results show that land use conversions in the study area between 1980 and 2015 were frequent, with the areas of farmland, woodland, grassland, water, and unused land decreasing by 5.00%, 17.12%, 21.59%, 18.31%, and 94.48%, respectively, while construction land increased by 53.61%. The key influences on land use change are the urbanization and growth of residential or non-agricultural populations. In 2035, the area of farmland in the study area will decrease by 11.09% compared with that in 2015 and construction land will increase by 38.94%, while the area of other land use types will not significantly change. Zhengzhou, as the center city, forms a diamond-shaped core development area of Zhengzhou–Kaifeng–Xinxiang–Jiaozuo, while Xuchang is considered an independent sub-center uniting the surrounding cities for expansion. With its radiation power of unipolar core development for many years and the developmental momentum of Zhengzhou–Kaifeng integration, Zhengzhou city jointly drives the economic development of the surrounding cities. The protection of farmland and control of the expansion of construction land are the major challenges for the Zhengzhou metropolitan area to achieve sustainable development.
Type Ib and IIb Supernova Progenitors in Interacting Binary Systems

We explore properties of Type Ib and IIb SN progenitors that are produced by stable mass transfer in binary systems using a new grid of stellar evolution models from an initial primary mass in the range of at solar and Large Magellanic Cloud metallicities. We find that blue and yellow supergiant SN IIb progenitors (e.g., of SN 2008ax, SN 2011dh, and SN 2016gkg) have a hydrogen envelope mass less than about , mostly resulting from early Case B mass transfer with relatively low initial masses and/or low metallicity. Red supergiant (RSG) SN IIb progenitors (e.g., of SN 1993J, SN 2013df) are produced via late Case B mass transfers and have a more massive hydrogen envelope ( ). SN Ib progenitors are predominantly produced by early Case B mass transfers. Our models predict that SN IIb progenitors are systematically more luminous in the optical ( ) than the majority of SN Ib progenitors ( ) for our considered initial mass range. However, the optically bright progenitor of SN Ib iPTF13bvn (i.e., ) can be well explained by a relatively low-mass progenitor with a final mass of . The event rate of blue and yellow SN IIb progenitors would increase as metallicity decreases, while the event rate of SN Ib progenitors would decrease instead. By contrast, the population of RSG SN IIb progenitors would not be significantly affected by metallicity.
Corneal Epithelial Regeneration: Old and New Perspectives

Corneal blindness is the fifth leading cause of blindness worldwide, and therapeutic options are still often limited to corneal transplantation. The corneal epithelium has a strong barrier function, and regeneration is highly dependent on limbal stem cell proliferation and basement membrane remodeling. As a result of the lack of corneal donor tissues, regenerative medicine for corneal diseases affecting the epithelium is an area with quite advanced basic and clinical research. Surgery still plays a prominent role in the treatment of epithelial diseases; indeed, innovative surgical techniques have been developed to transplant corneal and non-corneal stem cells onto diseased corneas for epithelial regeneration applications. The main goal of applying regenerative medicine to clinical practice is to restore function by providing viable cells based on the use of a novel therapeutic approach to generate biological substitutes and improve tissue functions. Interest in corneal epithelium rehabilitation medicine is rapidly growing, given the exposure of the corneal outer layers to external insults. Here, we performed a review of basic, clinical and surgical research reports on regenerative medicine for corneal epithelial disorders, classifying therapeutic approaches according to their macro- or microscopic target, i.e., into cellular or subcellular therapies, respectively.
A weakened cascade model for turbulence in astrophysical plasmas

A refined cascade model for kinetic turbulence in weakly collisional astrophysical plasmas is presented that includes both the transition between weak and strong turbulence and the effect of nonlocal interactions on the nonlinear transfer of energy. The model describes the transition between weak and strong MHD turbulence and the complementary transition from strong kinetic Alfven wave (KAW) turbulence to weak dissipating KAW turbulence, a new regime of weak turbulence in which the effects of shearing by large scale motions and kinetic dissipation play an important role. The inclusion of the effect of nonlocal motions on the nonlinear energy cascade rate in the dissipation range, specifically the shearing by large-scale motions, is proposed to explain the nearly power-law energy spectra observed in the dissipation range of both kinetic numerical simulations and solar wind observations.
Space Weather Environment During the SpaceX Starlink Satellite Loss in February 2022

On 3 February 2022, SpaceX Starlink launched and subsequently lost 38 of 49 satellites due to enhanced neutral density associated with a geomagnetic storm. This study examines the space weather conditions related to the satellite loss, based on observations, forecasts, and numerical simulations from the National Oceanic and Atmospheric Administration Space Weather Prediction Center (SWPC). Working closely with the Starlink team, the thermospheric densities along the satellite orbits were estimated and the neutral density increase leading to the satellite loss was investigated. Simulation results suggest that during the geomagnetic storm, pre‐launch Monte Carlo analyses performed by the Starlink team using empirical neutral density inputs from NRLMSISE‐00 tended to underestimate the impact relative to predictions from the operational coupled Whole Atmosphere Model and Ionosphere Plasmasphere Electrodynamics physics‐based model. The numerical simulation indicated this minor to moderate geomagnetic storm was sufficient to create 50%–125% density enhancement at altitudes ranging between 200 and 400 km. With the increasing solar activity of Solar Cycle 25, satellites in low‐Earth orbit are expected to experience an increasing number of thermospheric expansion events. Currently, no alerts and warnings issued by SWPC are focused on satellite users concerned with atmospheric drag and related applications. Thus, during geomagnetic storms, it is crucial to establish suitable alerts and warnings based on neutral density predictions to provide users guidance for preventing satellite losses due to drag and to aid in collision avoidance calculations.
Glutamate Prevents Altered Mitochondrial Function Following Recurrent Low Glucose in Hypothalamic but Not Cortical Primary Rat Astrocytes

Astrocytes contribute to glutamatergic signalling, which is required for hypoglycaemia counterregulation and is impaired by recurrent insulin-induced hypoglycaemia. This study examined the glutamate response of astrocytes when challenged with acute and recurrent low glucose (RLG) exposure. The metabolic responses of cortical (CRTAS) and hypothalamic (HTAS) primary rat astrocytes were measured in acute and recurrent low glucose using extracellular flux analyses. RLG caused mitochondrial adaptations in both HTAS and CRTAS, many of which were attenuated by glutamate exposure during low glucose (LG) treatments. We observed an increase in capacity of HTAS to metabolise glutamine after RLG exposure. Demonstrating astrocytic heterogeneity in the response to LG, CRTAS increased cellular acidification, a marker of glycolysis in LG, whereas this decreased in HTAS. The directional change in intracellular Ca2+ levels of each cell type, correlated with the change in extracellular acidification rate (ECAR) during LG. Further examination of glutamate-induced Ca2+ responses in low glucose treated CRTAS and HTAS identified sub-populations of glucose-excited- and glucose-inhibited-like cells with differing responses to glutamate. Lastly, release of the gliotransmitter ATP by HTAS was elevated by RLG, both with and without concurrent glutamate exposure. Therefore, hypothalamic astrocytes adapt to RLG by increasing glutamate uptake and oxidation in a manner that prevents RLG-induced mitochondrial adaptations.
Bifurcation and chaos in cellular neural networks

Bifurcation phenomena and chaotic behavior in cellular neural networks are investigated. In a two-cell autonomous system, Hopf-like bifurcation has been found, at which the flow around the origin, an equilibrium point of the system, changes from asymptotically stable to periodic. As the parameter grows further, by reaching another bifurcation value, the generated limit cycle disappears and the network becomes convergent again. Chaos is also presented in a three-cell autonomous system. It is shown that the chaotic attractor found here has properties similar to the famous double scroll attractor. >
Does financial development foster economic globalization in emerging economies? Time series evidence from China and India

This study explores the role of financial development in economic globalization for India and China by controlling economic growth, institutional quality, inflation, government investment, and real interest rate as crucial determinants. Using annual time series data from 1984 to 2018, the long-run estimates from ARDL model reveal that financial development, institutional quality, and government investment significantly drive economic globalization. We also find that the inflation rate offsets economic globalization in India but promotes it in China. Interestingly, while economic growth promotes economic globalization in India, it impedes in China. The varying effects of real interest rates on economic globalization are observed in both economies. These findings offer key macroeconomic policy.
New insights into the petrogenesis of rhyolites and evolution of volcanic‐hosted massive sulphide mineralization from shallow borehole core, Betul Belt, Central India

Shallow borehole drilling has been conducted at the Sarni area of Betul Belt, Central India to understand the subsurface geology and nature of mineralization. The predominant lithounits are ferruginous quartzites, felsic volcanic rocks, and with minor intrusions of amphibolites. The encountered felsic volcanic rocks are rhyolites varying from pink (rich in K‐feldspar) to grey (rich in Na‐feldspar and amphiboles). The rhyolitic rocks have undergone intense hydrothermal alteration. The alteration zones are defined by the presence of biotite‐chlorite‐garnet‐gahnite; biotite‐sericite‐chlorite‐anthophyllite and anthophyllite‐actinolite‐tremolite‐carbonate mineral assemblages. Sulphide pits, highly leached zones with occasional bluish tinges, limonitic patches are present in the felsic volcanic rocks, followed by semi‐massive to disseminated sulphide mineralization indicative of Kuroku‐ type Zn–Cu–Pb volcanic‐hosted Massive Sulphide (VHMS) mineralization. Scanning electron microscope and energy‐dispersive x‐ray spectroscopy studies documented sphalerite, pyrite, chalcophyrite, arsenopyrite, pyrrhotite, and minor Au–Ag phases. The Sarni rhyolites exhibit chalcopyrite disease in sphalerite, replacement, and overgrowth ore‐textures. The high HFSE, low Zr/Y ratio, pronounced negative Eu anomalies characterize the felsic volcanic rocks as FIIIb type with high zircon saturation temperatures of 856–931°C. These rhyolites are formed at a back‐arc rift setting in an ensialic island‐arc tectonic regime. The synvolcanic structures facilitated the magma ascent to the surface. The hydrothermal circulation due to adequate heat flow in the back‐arc rift environment, in an episodic multicyclic process provided sufficient time for accumulation of sulphides from the seafloor, which was later deposited to form a VHMS mineralization. We also report tungsten (W) mineralization in the quartz veins of these felsic volcanic rocks. It is suggested that the felsic magma has interacted with metasedimentary sequences and assimilated W‐ore bearing fluids, and during remobilization in the later stages of tectonic activity enabled the deposition of tungsten in these quartz veins.
Evaluation of Current Evidence on the Use of Oral Antiseptics Against SARS-CoV-2: A Narrative Review

Aims and Objectives: The detection of SARS-COV-2 in the oral cavity has generated endless claims about the efficacy of using oral mouthwashes to reduce viral load. This review aims to assess the current evidence on the use of oral antiseptics against SARS-CoV-2 and to assess the certainty of the evidence according to the GRADE system. The question this study focussed on was what is the efficacy of oral antiseptics against SARS-CoV-2? Materials and Methods: A bibliographic search was performed in Medline databases through PubMed, Science Direct, and Google Scholar (until February 2022), using search terms related to COVID-19 and oral antiseptics. Two independent researchers extracted the information from the articles included in an excel form. The identification and selection of the studies was carried out from August 2021 to February 2022. Results: It was found that oral antiseptics can have a potential beneficial effect on COVID-19, mainly in reducing viral load. However, these potential benefits are mainly based on in-vitro studies or clinical studies with various methodological limitations. At present, the certainty of the evidence is very low due to inconsistency (heterogeneity), moderate-to-high risk of bias, and imprecision of the results. Conclusion: The certainty of the current evidence on the efficacy of oral antiseptics against SARS-CoV-2 is very low, mainly due to the methodological limitations of the studies. Therefore, for evidence-based decision-making about this intervention, clinical studies with greater methodological rigor are required. Oral antiseptics could present potential benefits in patients with COVID-19 mainly by reducing viral load. However, a careful and conscious evaluation of the evidence is required for decision-making in clinical practice.
Pregnancy Outcomes after Frozen Embryo Transfer and Fresh Embryo Transfer in Women of Advanced Maternal Age: Single-Center Experience

Delayed childbearing leads to increased assisted reproductive technology use by women of advanced maternal age (AMA). It is unclear whether fresh or frozen embryo transfer (FET) is the better option. We aimed to assess maternal and neonatal outcomes in patients having their first FET after a freeze-all cycle versus those having their first fresh embryo transfer (ET). We reviewed 720 women of AMA undergoing a first fresh ET (n = 375) or FET (n = 345) between January 2016 and April 2021. No significant difference in the live birth rate was found between FET and fresh ET (19.7% vs. 24.3%, p = 0.141). The clinical pregnancy rate was significantly lower in the FET group than in the fresh ET group (26.4 % (91/345) vs. 33.6% (126/375), p = 0.035), but FET resulted in higher birthweights (3217.16 ± 734.44 vs. 3003.37 ± 635.00, p = 0.037) and was associated with a lower incidence of preterm births (2.6% vs. 5.6%, p = 0.046). The risks of other maternal and neonatal outcomes did not differ significantly between the groups. Among women of AMA, the transfer of frozen embryos did not result in significantly higher rates of live birth than fresh embryos did; however, a freeze-all strategy may not be beneficial for the women of AMA.
Fine asymptotic behavior for eigenvalues of random normal matrices: Ellipse case

We consider the random normal matrices with quadratic external potentials where the associated orthogonal polynomials are Hermite polynomials and the limiting support (called droplet) of the eigenvalues is an ellipse. We calculate the density of the eigenvalues near the boundary of the droplet up to the second subleading corrections and express the subleading corrections in terms of the curvature of the droplet boundary. From this result, we additionally get the expected number of eigenvalues outside the droplet. We also show that a certain Cauchy transform of the orthogonal polynomial vanishes in the bulk of the droplet up to an exponentially small error.
Functional and radiological outcomes of dynamic hip screw with trochanteric stabilizing plate versus short proximal femoral nail in management of unstable trochanteric fractures: A randomized-controlled trial

Objectives This study aims to compare dynamic hip screw (DHS) with trochanteric stabilizing plate (TSP) versus short proximal femoral nail (PFN) in unstable trochanteric fractures in terms of the functional and radiological outcomes. Patients and methods Between June 2019 and March 2020, a total of 68 patients (32 males, 36 females; mean age: 69.7±8.2 years; range, 60 to 88 years) with unstable trochanteric fractures were included in this randomized-controlled trial. Eligible patients were randomized to undergo DHS with TSP (n=34) or short PFN (n=34) and followed for 12 months. The outcome measures including Harris Hip Score (HHS), operating room time, the amount of blood loss and need for intraoperative transfusion, return to activity, time to union, postoperative complications, failure rate, and mortality rate were analyzed. Results The mean operative time in the DHS+TSP group was 105±10 min, while in the PFN group it was 94±8 min (p=0.001). The mean time until union in the DHS+TSP group was 10.1±1.9 weeks, while in the PFN group, it was 8.8±1.8 weeks (p=0.008). The mean time to return to the pre-fracture activity level in the DHS+TSP group was 12.6±2.6 weeks, while in the PFN group, it was 10.8±2.1 weeks (p=0.005). The mean HHS for the DHS+TPS group was 77.9±8.4, while for the PFN group, it was 80.4±8.7 (p=0.26). There was no significant difference in the walking capability between the two groups. One-year mortality rate was 29.4% in the PFN group and 17.6% in the DHS+TSP group (p=0.284), indicating no significant difference. Mechanical failure was recorded in three cases (8.8%) in the DHS+TSP group compared to two cases (5.8%) in the PFN group with no statistically significant difference. These five cases needed later revisions with total hip replacement. Conclusion The use of PFN in unstable trochanteric fractures was associated with a shorter time until union and a faster return to the pre-fracture level of activity than the DHS+TSP group. Postoperative hip function, walking independence, as well as complication and one-year mortality rates were comparable.
Exendin-4 and linagliptin attenuate neuroinflammation in a mouse model of Parkinson’s disease

Use of glucagon-like peptide-1 receptor agonist or dipeptidyl peptidase 4 inhibitor has been shown to lower the incidence of Parkinson's disease in patients with diabetes mellitus. Therefore, using these two treatments may help treat Parkinson's disease. To further investigate the mechanisms of action of these two compounds, we established a model of Parkinson's disease by treating mice with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and then subcutaneously injected them with the glucagon-like peptide-1 receptor agonist exendin-4 or the dipeptidyl peptidase 4 inhibitor linagliptin. We found that both exendin-4 and linagliptin reversed motor dysfunction, glial activation, and dopaminergic neuronal death in this model. In addition, both exendin-4 and linagliptin induced microglial polarization to the anti-inflammatory M2 phenotype and reduced pro-inflammatory cytokine secretion. Moreover, in vitro experiments showed that treatment with exendin-4 and linagliptin inhibited activation of the nucleotide-binding oligomerization domain- and leucine-rich-repeat- and pyrin-domain-containing 3/caspase-1/interleukin-1β pathway and subsequent pyroptosis by decreasing the production of reactive oxygen species. These findings suggest that exendin-4 and linagliptin exert neuroprotective effects by attenuating neuroinflammation through regulation of microglial polarization and the nucleotide-binding oligomerization domain- and leucine-rich-repeat- and pyrin-domain-containing 3/caspase-1/interleukin-1β pathway in a mouse model of Parkinson's disease induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Therefore, these two drugs may serve as novel anti-inflammatory treatments for Parkinson's disease.
When does the inflaton decay?

In order for the inflaton to decay into radiation at the end of inflation, it needs to couple to light matter fields. In this article we determine whether such couplings cause the inflaton to decay during inflation rather than after it. We calculate decay amplitudes during inflation, and determine to what extent such processes have an impact on the mean and variance of the inflaton, as well as on the expected energy density of its decay products. Although the exponential growth of the decay amplitudes with the number of e-folds appears to indicate the rapid decay of the inflaton, cancellations among different amplitudes and probabilities result in corrections to the different expectation values that only grow substantially when the number of e-folds is much larger than the inverse squared inflaton mass in units of the Hubble scale. Otherwise, for typical parameter choices, it is safe to assume that the inflaton does not decay during inflation.