Miracle-dz/UniFAR-FTUs huggingface dataset:
Labor Immobility, Stability Discourse, and LGBQ Young Adults’ Career Plans in Japan

Recent US studies showed that many lesbian, gay, bisexual, and queer (LGBQ) young adults develop hopeful views about their occupational careers by emphasizing future workplaces’ friendly climates and denying their risk of experiencing discrimination. The results may partly reflect American labor market conditions and social discourses that endorse these views, and little is known about how LGBQ young adults may perceive their career chances and make plans in different labor market and discursive conditions. To extend the literature, the present study focuses on LGBQ young adults in Japan and contrast the results to those from a US study based on an equivalent design. Analysis of in-depth interviews highlighted Japanese LGBQ young adults’ anticipation of chilly industry climates. Further, they disengaged sexuality from their career plans by prioritizing career stability over industry climates and by deciding to hide their sexual identities from their future colleagues. They explained these decisions by addressing the importance of labor immobility and by drawing on a social discourse that linked career stability to a better life. Overall, the results underscored that the ways in which people respond to social marginalization greatly depend on what structural resources and constraints exist and what social discourses are present in the national context.
Comprehensive Analysis Identifies PI3K/Akt Pathway Alternations as an Immune-Related Prognostic Biomarker in Colon Adenocarcinoma Patients Receiving Immune Checkpoint Inhibitor Treatment

Introduction In recent years, immune checkpoint inhibitors (ICIs) have attracted widespread attention and made breakthroughs in progress towards the treatment of various cancers. However, ICI therapy is selective, and its effects on many patients are not ideal. It is therefore critical to identify prognostic biomarkers of response to ICI therapy. The PI3K/Akt pathway plays important roles in tumor formation and metastasis. However, there are no published reports clarifying the relationship between PI3K/Akt pathway mutations and prognosis for colon adenocarcinoma (COAD) patients receiving immunotherapy. Methods We collected data from a COAD cohort from The Cancer Genome Atlas (TCGA) database, including whole-exome sequencing (WES) data, RNA-seq data, and clinical data. We also collected data, including clinical prognosis and targeted sequencing data, from a cohort of COAD patients receiving immunotherapy. We collected 50 COAD patients (Local-COAD) from the Zhujiang Hospital of Southern Medical University and performed targeted sequencing. We analyzed the effects of PI3K/Akt pathway mutations on the patients' clinical prognosis, immunogenicity, and immune microenvironments. Gene set enrichment analysis (GSEA) was used to analyze the significantly upregulated and downregulated signaling pathways. We used these results to hypothesize potential mechanisms by which PI3K/Akt mutations could affect the prognosis of COAD patients. Results Univariate and multivariate Cox analyses and Kaplan-Meier (KM) survival curves showed that patients with PI3K-Akt mutations had better overall survival (OS) than those without PI3K-Akt mutations. Genes with significant mutation rates in the two cohorts were screened by panoramic view. CIBERSORT was used to analyze changes in 22 types of immune cells to identify immune activated cells. Similarly, patients in the PI3K/Akt-mutated type (PI3K/Akt-MT) group had significantly increased immunogenicity, including increases in tumor mutation burden (TMB), neoantigen load (NAL), and MANTIS score. Using GSEA, we identified upregulated pathways related to immune response. Conclusion PI3K/Akt pathway mutation status can be used as an independent predictor of response to ICI treatment in COAD patients. PI3K/Akt mutations are correlated with improved OS, higher immunogenicity, greater immune response scores, and increases in activated immune cells.
Circulating microparticles and thrombin generation in patients with Chronic Lymphocytic Leukemia

Chronic Lymphocytic Leukemia (CLL) has shown great biological heterogeneity, with a variable prognosis, and a short survival in some patients. In this light, the present study focused on the prognostic utility of circulating microparticles (MPs) and a Thrombin Generation (TG) Profile for thrombotic risk and disease progression in CLL patients. Circulating microparticles and TG were evaluated in 35 patients with CLL and 35 healthy individuals. For circulating microparticles, significant differences were observed among the following groups: MPs derived from endothelial cells ( p = 0.002), B lymphocytes ( p < 0.001), platelets ( p = 0.003), and Tissue Factor MPs in monocytes ( p < 0.001). In all cases, MP values were higher for the CLL group. When compared to the controls, CLL patients presented a decrease in TG, characterized by a reduced endogen thrombin potential (ETP) ( p = 0.031). When the results were analyzed according to the Binet stage, as compared to the controls, the Binet B+C group also presented lower ETP values ( p = 0.009). No significant differences were observed between the control and the Binet A groups or between the Binet A and the Binet B + C groups. Although hemostatic alterations may occur in patients with CLL, these parameters do not seem to be useful to indicate disease progression.
Evaluation of the Thermophysical, Sensory, and Microstructural Properties of Colombian Coastal Carimañola Obtained by Atmospheric and Vacuum Frying

The quality of fried products affects consumer purchase decisions, and frying is an important stage in the production process. The objective of this research was to evaluate the thermophysical properties, the sensory quality, and microstructure of Colombian coastal Carimañola traditionally manufactured, in atmospheric frying and vacuum frying conditions. Lower moisture and fat content were reported in samples fried under vacuum compared to samples fried under atmospheric conditions, which is associated with the vacuum pressure during the process. Thermophysical properties, related to heat transfer in the samples, showed a correlation between thermal conductivity and moisture content. The micrographs visualized the changes in the porous structure of the coastal Carimañola. A greater effect was evidenced in the samples obtained by atmospheric frying because higher temperatures were used. The sensory evaluation reflected a preference for Carimañolas made with conventional frying. This research provides a basis for consumer purchases of traditionally fried products made with vacuum frying.
Assessing the willingness of patients’ companions to disclose bad news to cancer patients

Breaking bad news to patients is an essential aspect of the physician-patient relationship, but in Iran, this relationship is often disrupted by patients’ families. This study investigates the views of patients' companions on breaking cancer news. In this descriptive-analytic cross-sectional study, we conducted research on 170 cancer patients’ companions and 170 non-cancer patients’ companions. We designed a questionnaire to investigate the subjects’ opinions and used CVI, CVR, Cronbach's alpha and ICC for evaluation. In order to compare groups, we used Mann-Whitney, Kruskal-Wallis, Chi-square tests and Spearman’s correlation. Most participants believed that patients should be informed of their diagnosis. Cancer patients' companions were more willing to learn the bad news in case they were diagnosed with cancer and were less likely to choose “despair” as the reason for non-disclosure (71% vs. 44%). There was no difference between the two groups in willingness to break the cancer news to patients, choosing who should be informed first, and the reasons for non-disclosure. Most participants believed the family should be the first to know the diagnosis. In this study, most participants believed that patients should be informed of their diagnosis. However, they preferred to learn about the diagnosis before the patient, which confirms the importance of educating the families about autonomy.
Endoscopic ultrasound-directed transgastric ERCP (EDGE): A multicenter US study on long-term follow-up and fistula closure

Abstract Background and study aims Endoscopic ultrasound-directed transgastric ERCP (EDGE) is a safe and efficacious procedure to treat pancreaticobiliary diseases in Roux-en-Y gastric bypass (RYGB). This multicenter study aimed to determine the long-term outcomes of EDGE focusing on fistula persistence rates and post-procedure weight change. Patients and methods Information about patients with Roux-en-Y gastric bypass anatomy who underwent EDGE between 2015 and 2021 from 10 institutions was captured in a registry. Patient demographics, procedural details, and clinical outcomes were analyzed. Results One hundred seventy-two patients were included in the study (mean age 60, 25 % male). Technical success of lumen-apposing metal stent (LAMS) placement was 171 of 172 (99.4 %) while clinical success of intervention was 95%. The mean procedure time was 65 minutes. The most commonly reported complication was stent dislodgement/migration (n = 29, 17). Mean length of time of LAMS duration was 69 days. Mean follow-up time was 6 months. Endoscopic fistula closure was performed in 40 % of patients (69/172) at the time of LAMS removal. Persistence of fistula was observed in 19 of 62 patients (31 %) assessed. Length of LAMS indwell time (days) was a predictor of persistent fistula. The average weight gain while the LAMS was in place was 12 lb in 63 patients (36.6 %); 59.4 % of patients gained < 5 lb. Conclusions EDGE is a safe and efficacious procedure for RYGB patients requiring ERCP. Post-procedure evaluation and management of the enteral fistula varies widely among centers currently and would benefit from further standardization. Fistula persistence appears to be uncommon and can be managed endoscopically but may be related to length of indwell times of the LAMS.
RESPONSE OF THE PS II FUNCTION OF MORUS ALBA VAR. ‘QIUYU’ SEEDLING LEAVES TO DIFFERENT NITROGEN FORMS

In order to gain insights into the effect of different nitrogen forms on the photosynthetic ability of Morus alba, we studied chlorophyll fluorescence characteristics of one-year-old M. alba leaves treated with nitrate-nitrogen (NO3-N), ammonium-nitrogen (NH4-N) and ammonium nitrate (NH4NO3). We found that the PSII photochemical activity, electron transport rate and light energy usage of the M. alba leaves were significantly lower in plants treated with NH4-N compared to those treated with NO3-N and NH4NO3. We did not observe a significant difference in photosynthetic parameters between the NO3 -N and NH4NO3 treatments. There was an increase in the relative variable fluorescence values at the J step (VJ) and I step (VI) of M. alba leaves under the NH4-N treatment compared to the NO3-N and NH4NO3 treatments. In addition, the values of Vk and VL in M. alba leaves in plants treated with NH4N were significantly lower than the NO3-N and NH4NO3 treatments, suggesting that the inhibition of the oxygen-evolving complex (OEC) activity and the declined stability of the thylakoid membrane structure in M. alba leaves contributed to the decline of the photochemical activity in the PSII reaction center under the treatment of NH4-N.
Divide to conquer? The Silicon Valley - Boston 128 case revisited

The present paper investigates the role of decentralisation for the adaptability of production networks in clusters. It develops a simulation model able to test to what extent decentralised, networked clusters with many small firms (Silicon Valley) can be more adjustable than those composed of fewer, large companies (Boston 128). The model finds that for limited degrees of product complexity, decentralisation increases cluster adaptability at the expense of greater instability. This increases the risk of firm failure. Moreover, it is shown that agent numbers matter greatly for the competitiveness of decentralised clusters. Only if they host more firms than integrated cluster types is their lead in performance maintained. As a result, an additional condition had to be met to allow the Silicon Valley type to outperform the Boston 128 one: Greater firm numbers and strong startup dynamics.
MADE: A Computational Tool for Predicting Vaccine Effectiveness for the Influenza A(H3N2) Virus Adapted to Embryonated Eggs

Seasonal Influenza H3N2 virus poses a great threat to public health, but its vaccine efficacy remains suboptimal. One critical step in influenza vaccine production is the viral passage in embryonated eggs. Recently, the strength of egg passage adaptation was found to be rapidly increasing with time driven by convergent evolution at a set of functionally important codons in the hemagglutinin (HA1). In this study, we aim to take advantage of the negative correlation between egg passage adaptation and vaccine effectiveness (VE) and develop a computational tool for selecting the best candidate vaccine virus (CVV) for vaccine production. Using a probabilistic approach known as mutational mapping, we characterized the pattern of sequence evolution driven by egg passage adaptation and developed a new metric known as the adaptive distance (AD) which measures the overall strength of egg passage adaptation. We found that AD is negatively correlated with the influenza H3N2 vaccine effectiveness (VE) and ~75% of the variability in VE can be explained by AD. Based on these findings, we developed a computational package that can Measure the Adaptive Distance and predict vaccine Effectiveness (MADE). MADE provides a powerful tool for the community to calibrate the effect of egg passage adaptation and select more reliable strains with minimum egg-passaged changes as the seasonal A/H3N2 influenza vaccine.
The cycle ergometer test is not a reliable alternative to the countermovement jump in the assessment of power output

Background Rugby union is a physically demanding collision sport that requires optimal neuromuscular function for maximal power output, with mechanical power an integral component of performance. Peak power (Pp) and relative Pp are parameters of neuromuscular function commonly assessed through the countermovement jump (CMJ) as a measure of fatigue. The Wattbike cycle ergometer test (CET) is a non-load bearing method of evaluating lower limb power. The cost-effective CET could therefore offer a viable alternative to the CMJ. Objectives This study aimed to determine the concurrent validity of the CMJ and CET. Methods Thirty-eight professional rugby union players performed twelve CMJs on a force platform with four loads (bodyweight: BW-CMJ; 20kg: 20-CMJ; 40kg: 40-CMJ and 60kg: 60-CMJ) and a six second peak power (6PPO) CET assessment on a Wattbike ergometer. Results CMJ power outputs were [BW-CMJ: Pp − 3101±648 W; 20-CMJ: Pp − 2724±513 W; 40-CMJ: Pp − 2490±496 W; 60-CMJ: Pp − 2238±366 W] and CET [Pp – 1310±161 W]. None of the CMJ-Pp values showed relationships with any CET power variables. Large (r = 0.51–0.63; p = 0.000 – 0.001) relationships were found to be between relative CMJ and relative CET power outputs. Bland-Altman plots, which were used to determine the level of agreement between the two assessments, showed the agreement between the tests was poor. Conclusion Though positive relationships existed between relative CMJ and relative CET power variables, analyses of the level of agreement in the Bland-Altman plots suggest that the two power assessment methods are not interchangeable measures of power.
Development and Validation of a Nomogram for Adverse Outcomes of Geriatric Trauma Patients Based on Frailty Syndrome

Purpose Currently, assessing trauma severity alone in geriatric trauma patients (GTPs) cannot accurately predict the risk of serious adverse outcomes during hospitalization. As an emerging concept in recent years, frailty syndrome is closely related to the poor prognosis of many diseases in elderly patients, including trauma. A logistic model for predicting adverse outcomes in elderly trauma patients during hospitalization was constructed in elderly patients, and the predictive efficacy of the model was verified. Patients and Methods Trauma patients aged ≥65 years between June 2020 and September 2021 were selected and randomly divided into a training set and validation set at a ratio of 3:1. Mid arm muscle circumference (MAMC) was measured to determine the degree of frailty. LASSO regression was used to screen appropriate variables for the construction of a prognostic model. The logistic regression model was established and presented in the form of a nomogram. Calibration curves and ROC curves were used to verify the performance of the model. Results A total of 209 patients were enrolled, including 143 (68.4%) males and 66 (31.6%) females, with an average age of 70.8 ± 4.8 years. Ageless Charlson comorbidity index, BT unit, ISS, GCS, MAMC, prealbumin and lactic acid levels were screened by LASSO regression to construct a prognostic model. The AUC of the ROC analysis prediction model was 0.89 (95% CI 0.80–0.97) in the validation set. The results of the Hosmer–Lemeshow test for the validation set were χ2 = 11.23, P = 0.189. Conclusion The prognostic model of adverse outcomes in GTPs has good accuracy and differentiation, which can improve the prediction results of risk stratification of GTPs during hospitalization by medical staff and provide a new idea for prognostic prediction.
Mosquito-inspired Swarming and Pursuit for Autonomous Rotorcraft

Title of dissertation: MOSQUITO-INSPIRED SWARMING AND PURSUIT FOR AUTONOMOUS ROTORCRAFT Daigo Shishika, Doctor of Philosophy, 2017 Dissertation directed by: Professor Derek A. Paley Department of Aerospace Engineering Institute for Systems Research The long-term goal of this research is to design cooperative-control algorithms for autonomous vehicles inspired by the collective behaviors in animal groups. The specific research objectives of this dissertation are twofold: (1) to analyze and model the swarming and pursuit behaviors observed in the mating swarms of mosquitoes, and (2) to design mosquito-inspired control algorithms to perform swarming and pursuit with autonomous rotorcraft. The first part of this dissertation analyzes the reconstructed flight data of the malarial mosquito Anopheles gambiae to characterize the velocity-alignment interaction between male mosquitoes, who aggregate to form mating swarms and subsequently pursue a female mosquito. Both swarming and pursuit behaviors are represented using self-propelled particle models. The model is used together with tools from control theory to investigate the connection between velocity-alignment behavior and success in pursuit. The results of this research have a potential impact on vector-control methods for malaria, and are also utilized in the second part of this dissertation. The second part of this dissertation studies two types of pursuit problems inspired by the collective behavior in mosquito swarms. The first problem considers the strategy for a single pursuer chasing a single target. This problem has been studied extensively for the application to missile guidance and navigation. Here, we tailor the assumptions on the dynamics of the agents as well as the design criteria for the application to small and agile rotorcraft. The second pursuit problem incorporates the swarming behavior by considering a scenario in which multiple guardian vehicles are deployed to protect an area against fast intruders. We derive necessary and sufficient conditions for capturing the intruder. We also present swarming strategies to maximize the performance of the guardians, inspired by the random-oscillatory motion and the velocity-alignment behavior of male mosquitoes. MOSQUITO-INSPIRED SWARMING AND PURSUIT FOR AUTONOMOUS ROTORCRAFT
Growth of Carrot and Tomato from Oxamyl-coated Seed and Control of Meloidogyne hapla

Oxamyl was coated on carrot (Daucus carota L. cv. Spartan Fancy-80) and tomato (Lycopersicon esculentum Mill. cv. Glamour) seeds with a polymer sticker for the control of Meloidogyne hapla. The sticker diluted in water 1:1 delayed carrot seedling emergence. Oxamyl at 40 m g / m l in a 1:5 dilution of sticker lowered the rate of carrot seedling emergence until day 13 and plant growth until day 28. Oxamyl at 20 or 40 m g / m l in a 1:5 dilution of sticker on carrot seeds planted in M. hapla-infested muck soil resulted in fewer galled tap roots and fewer galls per root system 4 weeks after planting. Tap root lengths were greater than those of the control. Tomato seedling emergence was delayed and top and root weights were reduced, relative to the control, at 25 days by the sticker diluted 1:1 to 1:3. Oxamyl at 20 or 40 m g / m l in a 1:5 diluted sticker delayed tomato seedling emergence. Top weights of tomato seedlings from seeds coated with 20 m g / m l of oxamyl in a 1:5 diluted sticker planted in a silt loam were greater than control top weights at 4 and 6 weeks. Root weights were greater than those of the control only at 4 weeks. The re were fewer galls per gram of root on seedlings from oxamyl-coated seeds and fewer juveniles per pot of soil, relative to the controls, only at 4 weeks.
MMP-Dependent Shedding of ICAM-5 Occurs With LTP

Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that can be released or activated in a neuronal activity dependent manner. Although pathologically elevated levels of MMPs may be synaptotoxic, physiologically appropriate levels of MMPs may instead enhance synaptic transmission. MMP inhibitors can block long term potentiation (LTP), and at least one family member can affect an increase in the volume of dendritic spines. While the mechanism by which MMPs affect these changes is not completely understood, one possibility is that the cleavage of specific synaptic cell adhesion molecules plays a role. In the present study, we have examined the ability of neuronal activity to stimulate rapid MMP dependent shedding of the intercellular adhesion molecule-5 (ICAM-5), a synaptic adhesion molecule that is thought to inhibit the maturation and enlargement of dendritic spines. Since such cleavage would likely occur within minutes if it were relevant to a process such as LTP, we focused on post stimulus time points of thirty minutes or less. We show that NMDA can stimulate rapid shedding of ICAM-5 from cortical neurons in dissociated cell cultures and that such shedding is diminished by pretreatment of cultures with inhibitors that target MMP-3 and -9, proteases thought to influence synaptic plasticity. Additional studies suggest that MMP mediated cleavage of ICAM-5 occurs at amino acid 780, so that the major portion of the ectodomain is released. Since reductions in ICAM-5 have been linked to changes in dendritic spine morphology that are associated with LTP, we also examined the possibility that MMP dependent ICAM-5 shedding occurs following high frequency tetanic stimulation of hippocampal slices. Results show that the shedding of ICAM-5 occurs in association with LTP, and that both LTP and the associated ICAM-5 shedding are reduced when slices are pretreated with an MMP inhibitor. Together, these findings suggest that neuronal activity is linked to the shedding of a molecule that may inhibit dendritic spine enlargement and that MMPs can affect this change. While further studies will be necessary to determine the extent to which cleavage of ICAM-5 in particular contributes to MMP dependent LTP, our data support an emerging body of literature suggesting that MMPs are critical mediators of synaptic plasticity.