Miracle-dz/UniFAR-FTUs huggingface dataset:
Detection of Circulating Tumor Cells Using the Attune NxT

Circulating tumor cells (CTCs) have been detected in many patients with different solid malignancies. It has been reported that presence of CTCs correlates with worse survival in patients with multiple types of cancer. Several techniques have been developed to detect CTCs in liquid biopsies. Currently, the only method for CTC detection that is approved by the Food and Drug Administration is CellSearch. Due to low abundance of CTCs in certain cancer types and in early stages of disease, its clinical application is currently limited to metastatic colorectal cancer, breast cancer and prostate cancer. Therefore, we aimed to develop a new method for the detection of CTCs using the Attune NxT—a flow cytometry-based application that was specifically developed to detect rare events in biological samples without the need for enrichment. When healthy donor blood samples were spiked with variable amounts of different EpCAM+EGFR+ tumor cell lines, recovery yield was on average 75%. The detection range was between 1000 and 10 cells per sample. Cell morphology was confirmed with the Attune CytPix. Analysis of blood samples from metastatic colorectal cancer patients, as well as lung cancer patients, demonstrated that increased EpCAM+EGFR+ events were detected in more than half of the patient samples. However, most of these cells showed no (tumor) cell-like morphology. Notably, CellSearch analysis of blood samples from a subset of colorectal cancer patients did not detect CTCs either, suggesting that these blood samples were negative for CTCs. Therefore, we anticipate that the Attune NxT is not superior to CellSearch in detection of low amounts of CTCs, although handling and analysis of samples is easier. Moreover, morphological confirmation is essential to distinguish between CTCs and false positive events.
Pemahaman Konsep Matematika Siswa Berdasarkan Jenis Kelamin

Penelitian ini bertujuan untuk mengetahui pemahaman konsep matematika siswa berdasarkan jenis kelamin. Metode penelitian yang digunakan adalah deskriptif kuantitatif. Subjek pada penelitian ini adalah siswa kelas X IPA SMA N 1 Kecamatan Mungka yang terdiri dari 8 siswa laki-laki dan 13 siswa perempuan. Pengumpulan data dilakukan dengan tes. Hasil penelitian dari 8 siswa laki-laki sebanyak 5 siswa memperoleh kriteria pemahaman konsep sangat rendah dengan presentase sebesar 62%, 2 siswa berkriteria pemahaman konsep rendah dengan presentase sebesar 25%, dan 1 siswa memperoleh kriteria pemahaman konsep cukup dengan presentase sebesar 13%. Sedangkan kemampuan pemahaman konsep siswa perempuan dari 13 siswa adalah sebagai berikut: 5 siswa memperoleh kriteria pemahaman konsep sangat baik dengan presentase sebesar 38.46%, 5 siswa memperoleh kriteria pemahaman konsep baik dengan presentase sebesar 38.46%, 2 siswa memperoleh kriteria pemahaman konsep cukup dengan presentase sebesar 15.38%, dan 1 siswa memiliki kriteria pemahaman konsep sangat rendah dengan presentase sebesar 7.7%. Berdasarkan hasil penelitian terdapat perbedaan pemahaman konsep antara siswa laki-laki dan perempuan, dimana pemahaman konsep siswa perempuan lebih unggul dari siswa laki-laki. Hal ini dapat dilihat dari kriteria presentase pemahaman konsep siswa. Rendahnya pemahaman konsep sebagian siswa disebakan karena adanya kesulitan yang dihadapi siswa dalam memahami konsep
Acoustical design of Turkish Religious Affairs Mosque

The new Turkish Religious Affairs Mosque(DIB) with its prayer capacity and outstanding volume is the largest neo-classic mosque project of the past decade built in Ankara, Turkey. The Mosque is also one of unique examples of its scale for which the room acoustic design is applied in its design phase. Acoustical design of DIB Mosque is critical considering speech and music related activity patterns held in such religious spaces. Interior surface forms and materials of walls, floor, flat ceilings and dome are studied simultaneously with the architectural design as early as in the concept phase. Impedance tube is used for testing alternative materials for specifying sound absorption characteristics of reliefs and perforations. Computer simulation is applied as an acoustical design tool and estimations are held by ODEON v.11. 23. Objective acoustical parameters including reverberation time, speech transmission index and A-weighted sound levels are assessed with and without sound reinforcement systems for fully.
Eye-lens dose rate conversion factors due to hot particles and surface contaminations on the cornea

In 2012, the International Commission on Radiological Protection issued new recommendations, in publication 118, regarding the dose limits to the eye-lens. New analyses of historical exposure data had indicated that radiation-induced cataracts may appear at lower doses than previously assumed. This spurred largescale efforts in a variety of fields including dosimetry, radiation effects simulations, and the review of national regulatory limits. On the simulation side, much work led to the publication of dose rate conversion factors (DRCFs), to calculate the dose to the radiosensitive part of the eye-lens, and to the whole eye-lens as functions of the incident fluence of electron, photon, positron, and neutron radiation. The standard, ISO-15382 (2015 Radiological Protection—Procedures for Monitoring the Dose to the Lens of the Eye, the Skin and the Extremities), from the International Organization for Standardization (ISO), stated that the direct contact of a hot radioactive particle on the eye-lens represents a special contamination condition that must be considered. The aim of this work was to produce tabulated data of eye-lens dose rates, per activity (MBq), for a variety of radionuclides. In this work, the dose to the eye-lens from contamination directly in contact with the cornea, expressed in terms of DRCFs for eye-lens, in units of Gy h−1 MBq−1, are presented for 102 radionuclides of interest. These radionuclides were selected as they had been considered by the International Atomic Energy Agency of importance for skin dose. The method consisted of two steps. The first was the determination of the DRCFs for mono-energetic electrons and photons for a hot particle in contact with the eye-lens, followed by the folding of these quantities with the emissions of the radionuclides of interest. Contributions from spontaneous fission neutrons were considered separately. Exposure geometries for spherical hot particles of different dimensions, materials and locations on the cornea were considered. In addition, partial surface coverage of the cornea, consistent with an accidental exposure to a contaminated liquid, was also modelled. Resulting radionuclide DRCFs were verified, for a few specific geometries and radionuclides with dedicated Monte Carlo simulations. The final data are presented in several tables included in this paper.
Molecular glass positive i-line photoresist materials containing 2,1,4-DNQ and acid labile group

Recent years increasing attention has been given to molecular glass resist materials. In this paper, maleopimaric acid, cycloaddition reaction product of rosin with maleic anhydride, was reacted with hydroxylamine and then further esterified with 2-diazo-1-naphthoquinone-4-sulfonyl chloride to give N-hydroxy maleopimarimide sulfonate. The carboxylic acid group of the compound was then protected by the reaction of this compound with vinyl ethyl ether or dihydropyran. Thus obtained compounds were amorphous. When irradiated with i-line light, the 2,1,4-DNQ group undergo photolysis not only to give off nitrogen gas but also generate sulfonic acid which can result in the decomposition of the acid labile group. So, a novel chemically amplified positive i-line molecular glass photoresists can be formed by the compound and other acidolytic molecular glass compounds. The lithographic performance of the resist materials is evaluated.
Association Between ABCG2, ABCB1, ABCC2 Efflux Transporter Single‐Nucleotide Variants and Irinotecan Adverse Effects in Patients With Colorectal Cancer: A Real‐Life Study

Among patients treated with irinotecan, homozygous carriers of the UGT1A1*28 allele are at increased risk for neutropenia, but UGT1A1 genotype alone does not account for irinotecan‐induced toxicity. Our aim was to study the association between single‐nucleotide variants in genes encoding for efflux transporters of irinotecan (ABCG2, ABCB1, and ABCC2) and toxicity in real life. The source population was a cohort of patients with colorectal cancer (CRC) in Northern Israel, who had undergone genome‐wide association study. From the source population we chose the patients with CRC prescribed irinotecan, and a comparative cohort of patients with CRC treated with other anticancer systemic therapies. Using Clalit Health Services electronic medical records (including laboratory results) we ascertained hematological and gastrointestinal adverse effects and mortality, within 90 days of the first dose, as a composite outcome. There were 601 patients with CRC who received irinotecan, and 756 patients with CRC treated with other anticancer regimens. The minor allele in rs2231142 (ABCG2) was associated with lower incidence of the composite outcome (odds ratio (OR) = 0.54 (0.33, 0.91); P = 0.02) in irinotecan‐treated patients with CRC, but not in patients with CRC treated with other regimens. ABCB1 rs1045642 and ABCC2 rs3740066 were not associated with the composite outcome. In a sensitivity analysis, adjusted for UGT1A1 status and for possible demographic and clinical confounders, adjusted OR was 0.56 (0.33, 0.94) for the association between rs2231142 (ABCG2) and the composite outcome. In conclusion, we describe a novel association between the minor allele of rs2231142 in the efflux transporter gene ABCG2 and protection against severe side effects in CRC patients treating with irinotecan.
Correlation between residual stress and geometric tolerances in ultrasonic assisted turning

High accuracy in production parts and manufacturing quality are the requirements of production. Residual stress affects the surface quality and dimensional accuracy of manufactured parts. Production of parts with geometric tolerance, optimal residual stress, and suitable surface quality is always required by manufacturing industries. When machining parts, tensile residual stresses are created in them, which is one of the main reasons for the loss of geometric tolerances and distortion in the workpiece. This study investigated the effect of the ultrasonic-assisted vibration compared with conventional machining in various conditions of a 2024 aluminum workpiece on the surface quality, runout, straightness, and tensile residual stresses. In this article, the effects of geometric tolerance parameters, tensile residual stress, and surface roughness have been investigated simultaneously. A total of 18 experiments in different cutting speeds and feed rates in two machining states of conventional and ultrasonic vibration states were performed. The results showed that ultrasonic vibrations could be used to achieve 31% lower run out and 36% lower straightness in the parts. Also, the values of tensile residual stress in the ultrasonic vibration machining were 11% lower compared to conventional machining. Ultrasonic vibrations can also be used in most cases to achieve better surface quality, tolerance, and tensile residual stress according to machining parameters compared to conventional machining. The experimental results show that ultrasonic-assisted turning is a reliable method for machining, which can obtain lower tensile residual stress and improve the machined surface integrity and better tolerances.
Two steps generalized maximum entropy estimation procedure for fitting linear regression when both covariates are subject to error

This paper presents a procedure utilizing the generalized maximum entropy (GME) estimation method in two steps to quantify the uncertainty of the simple linear structural measurement error model parameters exactly. The first step estimates the unknowns from the horizontal line, and then the estimates were used in a second step to estimate the unknowns from the vertical line. The proposed estimation procedure has the ability to minimize the number of unknown parameters in formulating the GME system within each step, and hence reduce variability of the estimates. Analytical and illustrative Monte Carlo simulation comparison experiments with the maximum likelihood estimators and a one-step GME estimation procedure were presented. Simulation experiments demonstrated that the two steps estimation procedure produced parameter estimates that are more accurate and more efficient than the classical estimation methods. An application of the proposed method is illustrated using a data set gathered from the Centre for Integrated Government Services in Delma Island – UAE to predict the association between perceived quality and the customer satisfaction.
Particle dynamics in corrugated rectangular billiard

The particle dynamics in one side corrugated rectangular billiard system is investigated with the help of numerical analysis. The dependence of chaotic behavior in particle dynamics on the corrugation height h is shown. The focusing mechanism of the corrugated billiard is investigated by analyzing the dependence of the total path on particle incident angle.
Ideality factor of GaN-based light-emitting diodes determined by the measurement of photovoltaic characteristics

We present a method for determining the ideality factor of GaN-based light-emitting diodes (LEDs) by using the measured photovoltaic characteristics. The relation between the short-circuit current and the open-circuit voltage is obtained as the incident power of a laser diode emitting at 405 nm is varied, which is used to determine the ideality factor of the LED. From the photovoltaic measurements, the ideality factors of a blue and a green LED are determined to be 1.16 and 1.78, respectively. The ideality factors obtained by using the photovoltaic measurement are found to be much smaller than those obtained by using the I–V curve without illumination, which is believed to result from the different carrier generation and transport mechanisms. Investigating the photovoltaic characteristics of GaN-based LEDs is expected to provide insight into the origin of the high diode ideality factor in GaN-based devices.
Robust rank tests of the unit root hypothesis

The authors consider a family of rank tests based on the regression rank score process introduced by C. Gutenbrunner and J. Jureckova (1992) to test the unit root hypothesis in economic time series. In contrast to tests based on least-squares methods, the rank tests are asymptotically Gaussian under the null hypothesis, and have excellent power--particularly under innovation exhibiting heavy tails. These regression rank scores arise as a vector of solutions of the dual form of the linear program required to compute the regression quantile statistics of R. W. Koenker and G. Bassett (1978). For location model, they are simple ranks of the sample observations.
A Novel Ultrasonic Fatigue Test and Application in Bending Fatigue of TC4 Titanium Alloy

The very high cycle fatigue (VHCF) problems of thin-plate structures are usually caused by high-frequency vibrations. This paper proposes an accelerated fatigue test method based on ultrasonic loading technology in order to develop a feasible bending testing method and explore the bending fatigue characteristics of thin-plate structures in the VHCF regime. A new bending fatigue specimen with an intrinsic frequency of 20 kHz was designed based on cantilever bending through finite element simulation. It was verified by the axial load test with R = −1. The results showed that the method could effectively transfer the dangerous cross-section at the first-order cantilever bending restraint to the internal part of the specimen, thereby making the fracture location independent of the complex stresses. The linear relationship between the vibration amplitude and the maximum stress was also verified using strain measurements. Furthermore, the S-N curves and fracture morphology for different loading types were consistent with conventional studies to a certain extent, which indicated that the design of the bending test model was reasonable.
Literature review: the Effect of Company Size, Company Growth, and Company Liquidity on Going Concern Audit Opinion

Factors affecting going concern audit opinions have always been the focus of academic research. This article categorizes relevant previous research in Indonesia and analyzes several variables affecting audit opinion. This article examines the relationship or effect of company size, company growth, and company liquidity on going concern audit opinions, a study of auditing literature. This article aims to build a hypothesis of the effect between variables to be used in further research. This literature study shows the following results: 1) Company size has a negative effect on going concern audit opinion; 2) Company growth has a negative effect on going concern audit opinion; 3) Company liquidity has a negative effect on going concern audit opinion. This article provides a reference for more in-depth research on the factors affecting going concern audit opinions.
Study on the level of operational reliability of diesel engines for backhoe loaders

In the present study the main numerical characteristics of the reliability indicators for the Komatsu SAA4D104E-1 engines of the KOMATSU WB93R-5 backhoe loader have been determined, and the laws of resource allocation have been established. To study the level of reliability of machines, a methodology for experimental research has been developed, where the complex, comparative and formal methods, as well as the systematic, cybernetic and statistical approach have been used. It has been found that increasing the level of reliability of the engine elements can be improved by increasing the quality and timeliness of the repair and maintenance activities and compliance with the rules of operation. This study is a continuation of a study conducted by the author.
Downregulation of the Astroglial Connexin Expression and Neurodegeneration after Pilocarpine-Induced Status Epilepticus

Astrocytic networks and gap junctional communication mediated by connexins (Cxs) have been repeatedly implicated in seizures, epileptogenesis, and epilepsy. However, the effect of seizures on Cx expression is controversial. The present study focused on the response of Cxs to status epilepticus (SE), which is in turn an epileptogenic insult. The expression of neuronal Cx36 and astrocytic Cx30 and Cx43 mRNAs was investigated in the brain of rats in the first day after pilocarpine-induced SE. In situ hybridization revealed a progressive decrease in Cx43 and Cx30 mRNA levels, significantly marked 24 h after SE onset in neocortical areas and the hippocampus, and in most thalamic domains, whereas Cx36 mRNA did not exhibit obvious changes. Regional evaluation with quantitative real-time-RT-PCR confirmed Cx43 and Cx30 mRNA downregulation 24 h after SE, when ongoing neuronal cell death was found in the same brain regions. Immunolabeling showed at the same time point marked a decrease in Cx43, microglia activation, and interleukin-1β induction in some microglial cells. The data showed a transient downregulation of astroglial Cxs in the cortical and thalamic areas in which SE triggers neurodegenerative events in concomitance with microglia activation and cytokine expression. This could potentially represent a protective response of neuroglial networks to SE-induced acute damage.
In rabbits with cheyletiellosis is topical selamectin or injectable ivermectin a more effective treatment?

PICO question In rabbits with cheyletiellosis is topical selamectin or injectable ivermectin a more effective treatment? Clinical bottom line Category of research Treatment. Number and type of study designs reviewed One paper directly answered the PICO question, a retrospective clinical design study, and was critically reviewed. Strength of evidence. Strong. Outcomes reported Both topical selamectin and injectable ivermectin are safe and effective in treating cheyletiellosis. There is no significant difference in the effectiveness of both drugs in treating the infestation. Conclusion In pet rabbits with Cheyletiella parasitivorax infestations both topical selamectin and injectable ivermectin have been recognised to be a safe and effective treatment. There is currently insufficient evidence that one is more effective than the other and therefore veterinarians should consider their own clinical experience, client preference and use the licensed product first (in the UK, ivermectin (Xeno, Dechra) spot-on). However, this Knowledge Summary does not comment on the effectiveness of topical ivermectin in treating cheyletiellosis. If injectable ivermectin is , topical selamectin can be used under the cascade as an alternative treatment, as it is licensed for the same indication in dogs and cats. How to apply this evidence in practice The application of evidence into practice should take into account multiple factors, not limited to: individual clinical expertise, patient’s circumstances and owners’ values, country, location or clinic where you work, the individual case in front of you, the availability of therapies and resources. Knowledge Summaries are a resource to help reinforce or inform decision making. They do not override the responsibility or judgement of the practitioner to do what is best for the animal in their care.
Multi-Level Analysis of Health Care Demand in Uganda: Empirical Evidence from the National Household Survey – 2016/17

This study examines determinants of health-care demand in Uganda, by estimating mixed-effects logistic regressions using data from the Uganda National Household Survey (UNHS) - 2016/17. The study firstly compares the 2012/13 and 2016/17 UNHS data and finds that the demand for health care in Uganda has decreased, except for the sub-regions of Busoga, Central I, and Kigezi. Secondly, the results from a mixed-effects regression on the entire sample show that health-care demand at an individual level is associated with individual’s age, smoking habits, and non-communicable disease (NCD) status, whereas household size and poverty status determine health-care demand at the household level. Running separate models for each region to investigate regional peculiarities, the results show disparities in health-care demand among regions in Uganda. Therefore, to improve efficacy and health-care seeking behaviours of Ugandans, policies should recognize and be tailored to address individual, household as well as regional peculiarities. JEL Codes: A10, I11, I19