Miracle-dz/UniFAR-FTUs huggingface dataset:
TNF-α and IL-1β Promote Renal Podocyte Injury in T2DM Rats by Decreasing Glomerular VEGF/eNOS Expression Levels and Altering Hemodynamic Parameters

Purpose Diabetic nephropathy (DN) is a serious microvascular complication in those with type 2 diabetes mellitus (T2DM). Evidence confirms that serum tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) in the T2DM stage are proposed as prognostic markers for DN development, but it is unclear how they affect renal podocyte-associated nephrin and WT-1 expression. In the presence of podocyte injury, glomerular vascular endothelial growth factor (VEGF), endothelial nitric oxide synthase (eNOS) and hemodynamic parameters are dysregulated. The current research aimed to clarify the relationship of TNF-α and IL-1β with podocyte injury by altering VEGF/eNOS expression and hemodynamic parameters. Methods A high-fat diet/streptozotocin-induced DN rat model was established. Serum TNF-α and IL-1β levels were tracked in the pre-T2DM, T2DM and DN stages. In the DN stage, the mRNA and protein expression levels of renal TNF-α, IL-1β, VEGF, eNOS, nephrin and WT-1 were studied. Renal hemodynamic parameters, including peak systolic velocity, end-diastolic flow velocity and mean velocity were measured with a color Doppler ultrasound technique. Results Compared to those in the normal control (CTL) group, serum TNF-α and IL-1β levels increased significantly in the pre-T2DM stage (obesity, insulin resistance and hyperlipidemia), T2DM stage (hyperglycemia) and DN stage (abnormal renal functions) (all: P < 0.05) in the DN group. Serum TNF-α and IL-1β levels in the T2DM stage were significantly higher than those in the pre-T2DM stage (two: P < 0.05). Compared to the CTL group, renal nephrin, WT-1, TNF-α, IL-1β, eNOS and VEGF expression and hemodynamic parameters in the DN stage all showed significant differences separately (all: P < 0.05). Conclusion Increased serum and renal TNF-α and IL-1β levels played important roles in reducing renal nephrin and WT-1 expression levels, which may be related to the fact that the former affected renal VEGF/eNOS expression and blood flow parameters in the DN rats.
Clinical characteristics of patients infected with novel coronavirus wild strain, Delta variant strain and Omicron variant strain in Quanzhou: A real‑world study

This study aimed to investigate the clinical features of patients infected with novel coronavirus wild strains, Delta variant strains and Omicron variant strains to provide a reference for early clinical diagnosis and prognostic assessment. The demographic, clinical symptoms and ancillary examination data of 47 patients with novel coronavirus wild type strain infection, 18 with Delta variant infection and 20 with Omicron variant infection admitted to the First Hospital of Quanzhou affiliated with Fujian Medical University were collected and analyzed. The novel coronavirus wild strain and Delta strain were the predominant clinical types; patients infected with the Omicron strain were mainly asymptomatic. Fever and fatigue were the main clinical manifestations in the wild strain and Delta strain groups, whereas dry cough, nasal congestion, sore throat and fever were common clinical manifestations in the Omicron strain group. The Delta strain and Omicron variant groups had fewer comorbidities than the wild-type strain group, but no significant reduction was observed in the negative conversion time of nucleic acids. Significant differences were found in the neutrophil count/lymphocyte count ratio, lymphocyte count, eosinophil count, red blood cell count, hemoglobin level, erythrocyte sedimentation rate, C-reactive protein, prothrombin time, international normalized ratio and plasma D-dimer, PH, PaO2, lactic acid and albumin levels among the three groups. Patients infected with the Omicron strain in Quanzhou presented with mild symptoms of the upper respiratory tract as the primary clinical manifestation and had few comorbidities and a good prognosis; however, the negative conversion time of the new coronavirus nucleic acid was still considerably long.
Settlements along Main Road Axes: Blessing or Curse? Evaluating the Barrier Effect in a Small Greek Settlement

Being the heart of every human settlement, the road network constitutes a significant component of the built environment that serves the accessibility and mobility needs and supports economic activities. Despite its positive role, the road network, in some cases, due to increased geometric and functional characteristics, can act as a barrier to the movement of vulnerable road users, thus fragmenting the urban space and creating the phenomenon of the “barrier effect”. The barrier effect is considered detrimental to the mobility of vulnerable users, causing delays or even cancellation of trips, increasing collision risk, limiting access to services, posing negative impacts on public health, and loosening social ties. In this context, the current paper focuses on a settlement in Greece (Dispilio) developed along two national roads and comprehensively evaluates the barrier effect. More specifically, the presented methodological approach attempts to investigate the actual and the perceived dimension of this phenomenon by applying well-established metrics and landscape indicators, such as the effective mesh size, and conducting a questionnaire survey, respectively. The overall research results highlighted interesting findings regarding the intensity of the barrier effect in the examined area and outlined some critical interventions that could be implemented in similar cases.
Unsupervised Monocular Visual Odometry for Fast-Moving Scenes Based on Optical Flow Network with Feature Point Matching Constraint

Robust and accurate visual feature tracking is essential for good pose estimation in visual odometry. However, in fast-moving scenes, feature point extraction and matching are unstable because of blurred images and large image disparity. In this paper, we propose an unsupervised monocular visual odometry framework based on a fusion of features extracted from two sources, that is, the optical flow network and the traditional point feature extractor. In the training process, point features are generated for scene images and the outliers of matched point pairs are filtered by FlannMatch. Meanwhile, the optical flow network constrained by the principle of forward–backward flow consistency is used to select another group of corresponding point pairs. The Euclidean distance between the matching points found by FlannMatch and the corresponding point pairs by the flow network is added to the loss function of the flow network. Compared with SURF, the trained flow network shows more robust performance in complicated fast-motion scenarios. Furthermore, we propose the AvgFlow estimation module, which selects one group of the matched point pairs generated by the two methods according to the scene motion. The camera pose is then recovered by Perspective-n-Point (PnP) or the epipolar geometry. Experiments conducted on the KITTI Odometry dataset verify the effectiveness of the trajectory estimation of our approach, especially in fast-moving scenarios.
Strain mapping in an InGaN/GaN nanowire using a nano-focused x-ray beam

Strained InGaN/GaN core-shell nanowires (NWs) are promising candidates for solid state lighting applications due to their superior properties compared to planar films. NW based devices consist of multiple functional layers, which sum up to many hundred nanometers in thickness, that can uniquely be accessed in a non-destructive fashion by hard X-rays. Here, we present a detailed nanoscale strain mapping performed on a single, 400 nm thick and 2 μm long core-shell InGaN/GaN nanowire with an x-ray beam focused down to 100 nm. We observe an inhomogeneous strain distribution caused by the asymmetric strain relaxation in the shell. One side of the InGaN shell was fully strained, whereas the other side and the top part were relaxed. Additionally, tilt and strain gradients were determined at the interface with the substrate.
Rational intersection cohomology of projective toric varieties.

Intersection cohomology has been designed to make important topological methods — duality theory and intersection theory — available in the study of Singular spaces. To be able to apply these tools, it is important to know explicitly the intersection cohomology groups for given singular varieties. Torus embeddings provide an interesting class of in general singular varieties, äs they occur in many situations and äs their structure is easily described by means of combinatorial data.
Stellar Population Studies with the SDSS. I. The Vertical Distribution of Stars in the Milky Way

We present star count data from the Sloan Digital Sky Survey for 5.8 × 105 stars brighter than g' = 21 mag over 279 deg2 in two samples north and south of the Galactic plane. Using these high-latitude (49° < |b| < 64°) star counts we determine the Sun's distance from the Galactic midplane to be 27 ± 4 pc and the scale height of the old thin disk to be 330 ± 3 pc. Because of the photometric accuracy and large area sky coverage of these data, the color-magnitude diagram clearly reveals a significant thick-disk population distinct in color from a Galactic halo population. The position of the thick-disk turnoff is at g'-r' ~ 0.33. Several questions about the existence of the thick disk and its origin are addressed through a set of model fits to the star count data. Our best-fit model gives a thick-disk scale height between 580 and 750 pc, below the original proposal of Gilmore and Reid, and the corresponding space number density normalization is 13%-6.5% of the thin disk. The conclusions reached in this paper favor a scenario in which the thick disk formed through the heating of a preexisting thin disk, with the heating mechanism being the merging of a satellite galaxy. The density law for the Galactic halo population is also investigated. We find that the data support a flattened halo with c/a ~ 0.55 ± 0.06 and a relatively flat power-law index (2.5 ± 0.3). The axis ratio of the visible halo found in this paper is compatible with that of dark halo, suggesting that they have the same shape and dynamical origin.
Strengthening Modulus and Softening Strength of Nanoporous Gold in Multiaxial Tension: Insights from Molecular Dynamics

The functionalized applications of nanoporous metals place clear requirements on their basic mechanical properties, yet there is a lack of research on the mechanical response under multiaxial loading conditions. In this work, the mechanical behaviors of nanoporous gold under multiaxial tension are investigated via molecular dynamics simulations. The mechanical properties under different loading conditions are compared and the microstructure evolution is analyzed to clarify the deformation mechanisms of nanoporous gold in biaxial and triaxial tension. It is found that the modulus of nanoporous gold in multiaxial tension is strengthened and the strength is softened compared to uniaxial tension. The failure of nanoporous gold in multiaxial tension is dominated by the progressive yielding, necking, and rupture of ligaments along the multiple uniaxial loading directions. The dislocation activity under multiaxial loads is more intense and more prone to plastic deformation, ultimately resulting in lower strength and smaller failure strain. The findings provide more insight into the understanding of the deformation mechanisms of nanoporous metals under complex stress states.
The exploration of shared genes and molecular mechanisms of systemic lupus erythematosus and atherosclerosis

Objective Despite widespread recognition, the mechanisms underlying the relationship between systemic lupus erythematosus (SLE) and atherosclerosis (AS) are still unclear. Our study aimed to explore the shared genetic signature and molecular mechanisms of SLE and AS using a bioinformatics approach. Methods Gene expression profiles of GSE50772 (contains peripheral blood mononuclear cells from 61 SLE patients and 20 normal samples) and GSE100927 (contains 69 AS plaque tissue samples and 35 control samples) were downloaded from the Gene Expression Database (GEO) before the differentially expressed genes were obtained using the “limma” package in R. The differential genes were then subjected to gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis using the DAVID online platform to annotate their functions. The intersection targets of PPI and WGCNA were used as key shared genes for SLE and AS with their diagnostic value as shared genes being verified through ROC curves. Finally, Cytoscape 3.7. 2 software was used to construct a miRNA-mRNA network map associated with the shared genes. Results A total of 246 DEGs were identified, including 189 upregulated genes and 57 downregulated genes, which were mainly enriched in signaling pathways such as TNF signaling pathway, IL-17 signaling pathway, and NF-kB signaling pathway. The molecular basis for the relationship between SLE and AS may be the aforementioned signaling pathways. Following ROC curve validation, the intersection of PPI and WGCNA, as well as AQP9, CCR1, CD83, CXCL1, and FCGR2A, resulted in the identification of 15 shared genes. Conclusion The study provided a new perspective on the common molecular mechanisms between SLE and AS, and the key genes and pathways that were identified as being part of these pathways may offer fresh perspectives and suggestions for further experimental research.
Risk Factors for Fellow Eye Involvement in Patients with Nonarteritic Anterior Ischemic Optic Neuropathy

Introduction: The aim of the study was to investigate the possible risk factors for fellow eye involvement in patients with nonarteritic anterior ischemic optic neuropathy (NAION). Methods: A total of 113 patients with unilateral NAION attack were included and divided into two groups according to whether fellow eye involvement was present over a mean follow-up period of 2.70 years (P25–P75: 0.77–3.54 years). General characteristics (including age, sex, diabetes, hypertension, hyperlipidemia, and obstructive sleep apnea syndrome [OSAS]) and ocular characteristics (including initial best-corrected visual acuity, initial visual field damage of the first eye, and the presence/absence of a crowded disc) were analyzed and compared between the two groups. Cox regression was used to assess the risk factors for fellow eye involvement. Results: During the follow-up period, 40 patients developed fellow eye involvement. The initial best-corrected visual acuity (p = 0.048) and mean deviation of the visual field (VF) (p = 0.039) of the first eye in patients with fellow eye involvement were worse than those in patients without it. Diabetes (HR = 3.06, 95% CI: 1.50, 6.26, p = 0.002) and increased VF damage (moderate vs. mild, HR = 2.92, 95% CI: 1.03, 8.25, p = 0.043; severe vs. mild, HR = 5.01, 95% CI: 1.65, 15.20, p = 0.004) were associated with a significantly increased risk of fellow eye involvement. In 57 patients with apnea-hypopnea index (AHI) data for further study, an AHI score ≥23.2 was also found to be a risk factor (HR = 3.36, 95% CI: 1.17, 9.69, p = 0.025). Conclusion: Diabetes, severer initial VF damage, and more severe OSAS were risk factors for fellow eye involvement in NAION. For patients with these risk factors, more intensive follow-ups might be warranted.
Opinion on the re‐evaluation of sodium carboxy methyl cellulose (E 466) as a food additive in foods for infants below 16 weeks of age and follow‐up of its re‐evaluation as food additive for uses in foods for all population groups

Abstract Sodium carboxy methyl cellulose (E 466) was re‐evaluated in 2018 by the former EFSA Panel on Food Additives and Nutrient sources added to Food (ANS). As a follow‐up to this assessment, the Panel on Food Additives and Flavourings (FAF) was requested to assess the safety of E 466 for its uses as a food additive in food for infants below 16 weeks of age belonging to food categories (FC) 13.1. 5.1 (Dietary foods for infants for special medical purposes and special formulae for infants) in line with Regulation (EC) No 1333/2008. In addition, the FAF Panel was requested to address the issues already identified during the re‐evaluation of the food additive when used in food for the general population, including the safety assessment for FC 13.1. 5.1 and 13.1. 5.2 (Dietary foods for babies and young children for special medical purposes as defined in directive 1999/21/EC). The process involved the publication of a call for data. Based on the received data, the Panel concluded that the technical data provided by the interested business operator support an amendment of the specifications for sodium carboxy methyl cellulose (E 466) laid down in Commission Regulation (EU) No 231/2012. The interested business operators declared that E 466 is not used in food for infants below 16 weeks of age and in FC 13.1. 5.1. Due to the lack of data, an assessment has not been performed for this FC and age group. The interested business operators did not provide biological and toxicological data to support the uses of E 466 in FC 13.1. 5.2. Due to the almost unchanged database compared to the situation before the call for data, the FAF Panel confirmed the previous EFSA ANS Panel conclusion according to which the available data did not allow for an adequate assessment of the safety of use of sodium carboxy methyl cellulose (E 466) in infants and young children consuming foods belonging to the FC 13.1. 5.2. ©2022 European Food Safety Authority. EFSA Journal published by John Wiley and Sons Ltd on behalf of European Food Safety Authority.
Feasibility and Acceptability of a Telephone-Based Smoking Cessation Intervention for Qatari Residents

The steady increase in smoking rates has led to a call for wide-reaching and scalable interventions for smoking cessation in Qatar. This study examined the feasibility and acceptability of an evidence-based smoking cessation program delivered by telephone for Qatari residents. A total of 248 participants were recruited through primary care centers and received five weekly scheduled proactive behavioral counseling calls from personnel trained in tobacco cessation and navigation to obtain cessation pharmacotherapy from clinics. Outcomes were assessed at end of treatment (EOT), and 1- and-3-month follow up. The Mann–Whitney test was used to compare the average number of participants recruited per month pre- and post-COVID. We recruited 16 participants/month, the majority (85.5%) attended at least one counselling session, and 95.4% used some of pharmacotherapy. Retention rates were 70% at EOT, 64.4% and 71.7% at 1- and 3-month follow up, respectively; 86% reported being ‘extremely satisfied’ by the program. Our ITT 7-day point prevalence abstinence was 41.6% at EOT, 38.4% and 39.3% at 1-and 3-month, respectively. The average number of participants recruited per month was significantly higher for pre vs. post-COVID (18.9 vs. 10.0, p-value = 0.02). Average number of participants retained at EOT per recruitment month showed a slight decrease from 8.6 pre- to 8.2 post-COVID; average number who quit smoking at EOT per recruitment month also showed a decrease from 6 to 4.6. The study results indicated that our telephone-based intervention is feasible and acceptable in this population and presents a new treatment model which can be easily disseminated to a broad population of Qatari smokers.
Diagnosis and Management of Dysgerminomas with a Brief Summary of Primitive Germ Cell Tumors

Dysgerminoma represents a rare malignant tumor composed of germ cells, originally from the embryonic gonads. Regarding its incidence, we do not have precise data due to its rarity. Dysgerminoma occurs at a fertile age. The preferred treatment is the surgical removal of the tumor succeeded by the preservation of fertility. Even if a multidisciplinary team, founded in 2009 by a gynecologist, an oncologist, a pediatric oncologist and a pediatric surgeon, under the guidance of the Malignant Germ Cell International Consortium (MaGIC), studies this type of tumor, issues still remain related to the lack of a randomized study and to both the management and understanding of the concept of OMGCTs (ovarian malignant germ cell tumors). The aim of this review is to present from the literature the various approaches for this type of tumor, and, regarding innovative therapies or possible prevention, which can be applied in clinical practice. Multidisciplinarity and treatment in reference centers have proven their usefulness as well.
High Resistance to Antibiotics Recommended in Standard Treatment Guidelines in Ghana: A Cross-Sectional Study of Antimicrobial Resistance Patterns in Patients with Urinary Tract Infections between 2017–2021

Management of urinary tract infections is challenged by increasing antimicrobial resistance (AMR) worldwide. In this study, we describe the trends in antimicrobial resistance of uropathogens isolated from the largest private sector laboratory in Ghana over a five-year period. We reviewed positive urine cultures at the MDS Lancet Laboratories from 2017 to 2021. The proportions of uropathogens with antimicrobial resistance to oral and parenteral antimicrobials recommended by the Ghana standard treatment guidelines were determined. The proportion of multi-drug resistant isolates, ESBL and carbapenemase-producing phenotypes were determined. Of 94,134 urine specimens submitted for culture, 20,010 (22.1%) were culture positive. Enterobacterales was the most common group of organisms, E. coli (70.6%) being the most common isolate and Enterococcus spp. the most common gram-positive (1.3%) organisms. Among oral antimicrobials, the highest resistance was observed to ciprofloxacin (62.3%) and cefuroxime (60.2%) and the least resistance to fosfomycin (1.9%). The least resistance among parenteral antimicrobials was to meropenem (0.3%). The highest multi-drug resistance levels were observed among Klebsiella spp. (68.6%) and E. coli (64.0%). Extended-spectrum beta-lactamase (ESBL) positivity was highest in Klebsiella spp. (58.6%) and E. coli (50.0%). There may be a need to review the Ghana standard treatment guidelines to reflect increased resistance among uropathogens to recommended antimicrobials.
Programmable Thermo-Responsive Self-Morphing Structures Design and Performance

Additive manufacturing (AM), also known as 3D printing, was introduced to design complicated structures/geometries that overcome the manufacturability limitations of traditional manufacturing processes. However, like any other manufacturing technique, AM also has its limitations, such as the need of support structures for overhangs, long build time etc. To overcome these limitations of 3D printing, 4D printing was introduced, which utilizes smart materials and processes to create shapeshifting structures with the external stimuli, such as temperature, humidity, magnetism, etc. The state-of-the-art 4D printing technology focuses on the “form” of the 4D prints through the multi-material variability. However, the quantitative morphing analysis is largely absent in the existing literature on 4D printing. In this research, the inherited material anisotropic behaviors from the AM processes are utilized to drive the morphing behaviors. In addition, the quantitative morphing analysis is performed for designing and controlling the shapeshifting. A material–process–performance 4D printing prediction framework has been developed through a novel dual-way multi-dimensional machine learning model. The morphing evaluation metrics, bending angle and curvature, are obtained and archived at 99% and 93.5% R2, respectively. Based on the proposed method, the material and production time consumption can be reduced by around 65–90%, which justifies that the proposed method can re-imagine the digital–physical production cycle.