Miracle-dz/UniFAR-FTUs huggingface dataset:
Expression of Several Gene Sets

Genetic studies using Arabidopsis offer a promising approach to investigate the mechanisms of light signal transduction during seedling development. Several mutants, called detlcop, have been isolated based on their deetiolated/constitutive photomorphogenic phenotypes in the dark. This study examines the specificity of the deUcop mutations with respect to their effects on genes regulated by other signal transduction pathways. Steady state mRNA levels of a number of differently regulated gene sets were compared between mutants and the wild type. We found that det2, cop2, COp3, and cop4 mutants displayed a gene expression pattern similar to that of the wild type. By contrast, det7, copl, and cop9 mutations exhibited pleiotropic effects. In addition to light-responsive genes, genes normally inducible by plant pathogens, hypoxia, and developmental programs were inappropriately expressed in these mutants. Our data provide evidence that DET1, COPl, and COP9 most likely act as negative regulators of severa1 sets of genes, not just those involved in light-regulated seedling development.
Colour M-mode velocity propagation: a glance at intra-ventricular pressure gradients and early diastolic ventricular performance

The physiology of early-diastolic filling comprises ventricular performance and fluid dynamical principles. Elastic recoil and myocardial relaxation rate determine left ventricular early diastolic performance. The integrity of left ventricular synchrony and geometry is essential to maintain the effect of their timely action on early diastolic left ventricular filling. These factors not only are prime determinants of left ventricular pressure decay during isovolumic relaxation and immediately after mitral valve opening; they also instigate the generation of a sufficient intra-ventricular pressure gradient, which enhances efficient early diastolic left ventricular filling. Accurate assessment of diastolic (dys)function by non-invasive techniques has important therapeutic and prognostic implications but remains a challenge to the cardiologist. The evaluation of left ventricular relaxation by the standard Doppler echocardiographic parameters is hindered by their preload dependency. The colour M-mode velocity propagation of early diastolic inflow (Vp) correlates with intra-ventricular pressure gradients and is a largely preload independent index of ventricular diastolic performance. In this article, the physiologic background, utility and limitations of this promising new tool for the study of early diastolic filling are reviewed. D 2004 European Society of Cardiology. Published by Elsevier B.V. All rights reserved.
Identi�cation of a Glycolysis-Related Gene Signature for Survival Prediction of Ovarian Cancer Patients

Background: Ovarian cancer (OV) is deemed as the most lethal gynecological cancer in women. The aim of this study was construct an effective gene prognostic model for OV patients. Methods: The expression pro�les of glycolysis-related genes (GRGs) and clinical data of patients with OV were extracted from The Cancer Genome Atlas (TCGA) database. Univariate, multivariate, and least absolute shrinkage and selection operator Cox regression analyses were conducted, and a prognostic signature based on GRGs was constructed. The predictive ability of the signature was analyzed in training and test sets. Results: Based on nine GRGs (ISG20, CITED2, PYGB, IRS2, ANGPTL4, TGFBI, LHX9, PC, and DDIT4), a gene risk signature was identi�ed to predict the outcome of patients with OV. The signature showed a good prognostic ability for OV, particularly high-grade OV, in the TCGA dataset, with areas under the curve of 0.709, 0.762, and 0.808 for 3-, 5-and 10-year survival, respectively. Similar results were found in the test sets, and the signature was also an independent prognostic factor. Moreover, a nomogram combining the prediction model and clinical factors was constructed. Conclusion: Our study established a nine-GRG risk model and a nomogram to better perform on OV patients’ survival prediction. The risk model represents a promising and independent prognostic predictor for OV patients. Moreover, our study of GRGs could offer guidances for underlying mechanisms explorations in the future.
Business Sustainability and Innovation DETERMINANTS OF INSURANCE AGENTS BEHAVIOURAL INTENTION TO USE MOBILE TECHNOLOGIES

In today's dynamic digital era, critical functions in businesses are being affected by mobile technologies with the ability to collect instant data thus providing valuable insights to managers towards achieving business sustainability. This study examined the determinants of behavioural intention to use mobile technologies in business among insurance agents in Malaysia based on a modified Unified Theory of Acceptance and Use of Technology 2. In addition, this study investigated the impact of age, voluntariness and experience on associations between the determinants and behavioural intention to use mobile technologies. Utilizing online questionnaires survey, a total of 208 usable responses were collected. The results suggested that performance expectancy, facilitating conditions, social influence, hedonic motivation, personal innovativeness and habit are significant in determining the behavioural intention. Nevertheless, effort expectancy and price value do not have any impact. Experience in using mobile technologies moderates the relationship between personal innovativeness and behavioural intention; but age only moderates the relationship between habit and behavioural intention. Interestingly, the effect of habit on behavioural intention to use was found to be influenced by voluntariness. Findings from this study contribute in enhancing the utilisation of mobile technologies at work which subsequently increases the efficacy and business sustainability of insurance industry in emerging economies such as Malaysia
OP-SCAN140045 209..218

This functional magnetic resonance imaging study examined the neural correlates of punishment and forgiveness of initiators of social exclusion (i.e. excluders ). Participants divided money in a modified Dictator Game between themselves and people who previously either included or excluded them during a virtual ball-tossing game (Cyberball). Participants selectively punished the excluders by decreasing their outcomes; even when this required participants to give up monetary rewards. Punishment of excluders was associated with increased activation in the pre-supplementary motor area (preSMA) and bilateral anterior insula. Costly punishment was accompanied by higher activity in the pre-SMA compared with punishment that resulted in gains or was non-costly. Refraining from punishment (i.e. forgiveness) was associated with self-reported perspective-taking and increased activation in the bilateral temporoparietal junction, dorsomedial prefrontal cortex, dorsal anterior cingulate cortex, and ventrolateral and dorsolateral prefrontal cortex. These findings show that social exclusion can result in punishment as well as forgiveness of excluders and that separable neural networks implicated in social cognition and cognitive control are recruited when people choose either to punish or to forgive those who excluded them.
A Comparative Analysis based approach for Bitcoin Price Forecasting

— Bitcoin, one of the most famous and high- in-demand cryptocurrencies, is a type of digital asset that is extremely difficult to track and make predictions upon. In addition, Bitcoin price does not correlate with market-movements, therefore, predicting its price action and its locus is an ordeal. In this paper, we have followed a comparative analysis approach, wherein we are using four different models to predict the trend of BTC Time series data. The results justify that the models have achieved accurate forecasting trends. During the period of 16th to 31st December 2020, Bitcoin prices experienced considerably high swings, due to the increased demand for it. In quantitative terms, the prices experienced fluctuations to the tune of 8000 USD. Despite these enormous price changes, we were able to achieve a model, that helped us attain a Mean Absolute Error (MAE) of 153.55 USD and Mean Square Error (MSE) of 43231.80 USD. Conventional Bitcoin price predicting researches follow a single to two model approach. However, for a highly volatile asset like Bitcoin, making long-term predictions and generalizing them based on limited number of models results in low accuracy outputs. This gap has been bridged in our research, we have worked with different models, as well as fragmented the time intervals into smaller portions, post which the prediction was made for only 2 days. Using this approach, we attained results with least error rates. The results obtained clearly show that ARIMA is the best model for predicting the future trends for BTC time series data. It takes into account the different types of decompositions like Regular Trend, Sessional and Residual Trend making the model give the best results.
Non genetic factors affecting lactation milk yield and estimation of genetic, environmental and phenotypic trends in Surti buffalo

The records of 457 Surti buffaloes covering 1346lactations sired by 35 sires maintained at Livestock Research Station, Navsari Agricultural University, Navsari born during 1987 to 2012 were collected and analysed to examine the effect of nongenetic factors viz. season of birth, period of birth and parity on lactation milk yield.The least squares mean forlactation milk yield in Surti buffaloes was 1140.55 ± 38.33 kg. The analysis of variance revealed highly significant effects of period of birth and parity on lactation milk yield. Lactation milk yield significantly increased from 1044.77 ± 37.70 kg in 1 parity and recorded to be highest during 3 to 7 parities (1164.98 to 1220.72 kg). Highest lactation milk yield in 5 parity and significant increase in milk yield up to 7 parity indicates potential of breed for long day yielder without any seasonal effect. Genetic trend for lactation yieldwas found to be positive (20.14 ± 58.23 kg) by LSMBL method and it was negative (-13.15 ± 1.89 kg) by BLUP method.The environmental trends for lactation yield were 44.37 ± 61.30 kgand 77.66 ± 19.27 kgrespectively by LSMBL and BLUP methods. The phenotypic trend was also found positive (64.51 ± 19.18 kg) for lactation yield in the present study. Negative genetic trend by BLUP method stressed the need to use proven sires for attaining desired genetic improvement. Positive environmental trend indicated good managemental practises followed by the farm which also contribute to positive phenotypic trend.
AHEART April 47/4

McNulty, Patrick H. , Dinesh Jagasia, Jennifer M. Whiting, and Teresa Caulin-Glaser. Effect of 6-wk estrogen withdrawal or replacement on myocardial ischemic tolerance in rats. Am J Physiol Heart Circ Physiol 278: H1030– H1034, 2000. —Menopausal status is a risk factor for coronary artery disease death, but the mechanism underlying this association is uncertain. To test whether estrogen ameliorates the effects of acute myocardial ischemia in ways likely to translate into a mortality difference, we compared the response to brief (6-min) and prolonged (45-min) coronary occlusion in vivo in five groups (each n 5 16) of rats: ovariectomized females; ovariectomized females after 6 wk 17b-estradiol replacement; male rats supplemented with estradiol for 6 wk; normal males; and normal females. Coronary occlusion produced a uniform ischemic risk area averaging 53 6 3% of left ventricular volume. After a brief occlusion, reperfusion ventricular tachycardia/fibrillation occurred with . 85% frequency in all groups. During a prolonged occlusion, ischemic ventricular tachycardia occurred in 100% and sustained tachycardia requiring cardioversion in . 75% of rats in all groups. Myocardial infarct size averaged 52 6 4% of the ischemic risk area and was similarly unaffected by gender or estrogen status. We conclude that neither short-term estrogen withdrawal, replacement, nor supplementation significantly affects the potentially lethal outcomes from acute coronary occlusion in this species.
PRBM_A_318657 1223..1234

1Center for Mental Health Research in School of Management, Zunyi Medical University, Zunyi, People’s Republic of China; 2School of Criminal Justice, China University of Political Science and Law, Beijing, People’s Republic of China Background: Empathy is shown to affect the attentional processing of painful stimuli and emotional stimuli. However, whether the attentional effects on emotional stimuli depend on emotional valence and the nature of the relationship between the attentional effects on different stimuli are still unknown. Methods: In the present study, 25 high-empathy (HE) participants and 25 low-empathy (LE) participants were recruited to perform dot-probe tasks on painful stimuli and emotional stimuli. Results: The results showed that HE individuals had weak attentional disengagement to painful pictures. More importantly, regarding emotional pictures, HE individuals showed attentional avoidance to negative emotion pictures, while LE individuals showed attentional bias to positive emotion pictures. Correlation analysis showed that the attentional bias score and attentional disengagement score were only associated with each other within the same category of stimuli (painful, positive or negative stimuli). Conclusion: These results revealed that HE individuals mainly showed attentional avoidance to negative stimuli, while LE individuals mainly showed attentional bias to positive stimuli.
COPD_A_312190 2039..2047

1State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Diseases, National Clinical Research Center for Respiratory Disease Guangzhou, First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, Guangdong Province, People’s Republic of China; 2Department of Respiratory and Critical Care Medicine, First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, People’s Republic of China; 3The People’s Hospital of Hubei Province, Wuhan, Hubei Province, People’s Republic of China; 4The First People’s Hospital of Guangzhou City, Guangzhou, Guangdong Province, People’s Republic of China
Insights from mercury stable isotopes into factors a"ecting the internal body burden of methylmercury in frequent #sh consumersMercury stable isotopes in frequent #sh consumers

Methylmercury (MeHg) exposure can cause adverse health e1ects in children and adults and is predominantly from seafood consumption in the United States (U.S.). Here we examine evidence for di1erences in MeHg uptake and metabolism in U.S. individuals who consume three or more 2sh meals per week. We hypothesized based on prior research that some individuals have enhanced capacity to demethylate ingested MeHg and this will be re3ected by a greater than typically observed δHg o1set in their hair relative to consumed 2sh (∼2 ‰). We used self-reported seafood intake data to identify individuals with hair Hg concentrations that agree extremely well with reported ingestion and those that do not. Approximately one-third of individuals in our survey population had hair Hg levels below the lower bound of probabilistic exposure modeling based on dietary intake data. 6e ΔHg values measured in the hair of a subset of individuals with the highest and lowest discrepancies between modeled and measured exposures are consistent with self-reported 2sh intake, validating the reliability of their dietary recall information. 6e δHg o1set between 2sh and human hair is similar for lowand high-discrepancy individuals, suggesting enhanced in vivo demethylation does not explain some individuals with hair Hg levels equivalent to non-2sh consumers (0.10 ug/g). Using the probabilistic exposure model, we 2nd dietary MeHg absorption e9ciencies required to explain hair Hg levels in these high-discrepancy individuals are on average lower than 14% (range: 1%–72%). Exposure modeling for MeHg typically assumes a range of 91–97% and our results emphasize much greater inter-individual variability in this value.
Risk Factors of Childbirth Complication at Koya Barat Public Health Center, Jayapura City

Background: Labor complications are a sign of danger that occurs in a pregnant woman at the time of delivery. The incidence of childbirth complications needs to have a good health protection to save the health status of mothers and children according to the standard of delivery assistance that is covered by health workers. Objective: The aim of the study was to determine the risk factors for childbirth complications in mothers who gave birth at the Koya Barat Health Center. Methods: This research is a type of analytical survey research with a cross sectional approach using secondary data from the 2020 Maternal and Child Health Report (KIA). The population of this study was all mothers giving birth at the Koya Barat Puskesmas from January to December 2020, totaling 261 mothers giving birth. The sampling technique used in this study was total sampling. The data were processed using analysis, Frequency Distribution, Chi-square, Prevalence Ratio Test, Logistic Regression. Results: The results of the bivariate analysis found that variables age (p < 0.01; RP=1.862; 95%CI: 1.4322.423), parity (p = 0.045; RP=1.385; 95%CI: 1.043-1.841), and Hb level (p = 0.024; RP=1.422; 95%CI: 1.0591.908) has a significant relationship with the childbirth complication at Koya Barat Public Health Center. Meanwhile, education (p = 0.095; RP=1.306; 95%CI: 0.984-1.733) has no significant relationship with the childbirth complication at Koya Barat Public Health Center. Based on the results of multiple logistic regression analysis, the most dominant risk factors for childbirth complication at Koya Barat Public Health Center is age (p < 0.01; OR = 3.507; 95%CI: 1.922 – 6.401).
Small-molecular virulence inhibitors show divergent and immunomodulatory effects in infection models of serovar Typhimurium

HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignement et de recherche français ou étrangers, des laboratoires publics ou privés. Small-molecular virulence inhibitors show divergent and immunomodulatory effects in infection models of serovar Typhimurium Speranta Puiac, Xiaohui Sem, Aurel Negrea, Mikael Rhen
OTT_A_214905 7039..7044

Introduction T-lymphoblastic leukemia/lymphoma (T-ALL/LBL) is a precursor lymphoid neoplasm that occurs in bone marrow and blood (T-ALL) or involves the thymus, lymph nodes, or extranodal sites (T-LBL). The thymus is the most common site involved by T-LBL, which is located in the anterior mediastinum and holds the key to T-cell development. There are four stages of intrathymic differentiation related to T-ALL/LBL according to the antigens expressed: 1) pro-T/T-I, 2) pre-T/T-II, 3) cortical T/T-III, and 4) medullary T/T-IV. Early T-cell precursors (ETPs) usually belong to pro-T and pre-T cells and retain multiple potentials for T-cells and natural killer cells as well as myeloid lineage and dendritic cell differentiation. ETP-ALL, as a neoplasm from ETP, has been defined to be a new subtype of T-ALL/LBL in 2016 WHO classification. The diagnosis of ETP-ALL is mainly based on a set of unique immunophenotypes: expresses CD7, cytoplasmic CD3 (cCD3), and one or more of the myeloid/stem cell markers CD34, CD117, Correspondence: Yanyan Liu Department of Internal Medicine, Affiliated Cancer Hospital of Zhengzhou University, 127 Dong Ming Road, Zhengzhou, Henan 450008, People’s Republic of China Email yyliu@zzu.edu. cn
Characterization of InO of Pseudomonas aeruginosa Plasmid pVS 1 , an Ancestor of Integrons of Multiresistance Plasmids and Transposons of Gram-Negative Bacteria

Many multiresistance plasmids and transposons of gram-negative bacteria carry related DNA elements that appear to have evolved from a common ancestor by site-specific integration of discrete cassettes containing antibiotic resistance genes or sequences of unknown function. The site of integration is flanked by conserved segments coding for an integraselike protein and for sulfonamide resistance, respectively. These segments, together with the antibiotic resistance genes between them, have been termed integrons (H. W. Stokes and R. M. Hall, Mol. Microbiol. 3:1669-1683, 1989). We report here the characterization of an integron, InO, from Pseudomonas aeruginosa plasmid pVSI, which has an unoccupied integration site and hence may be an ancestor of more complex integrons. Codon usage of the integrase (int) and sulfonamide resistance (sull) genes carried by this integron suggests a common origin. This contrasts with the codon usage of other antibiotic resistance genes that were presumably integrated later as cassettes during the evolution and spread of these DNA elements. We propose evolutionary schemes for (i) the genesis of the integrons by the site-specific integration of antibiotic resistance genes and (ii) the evolution of the integrons of multiresistance plasmids and transposons, in relation to the evolution of transposons related to Tn2l.
Expression of native and mutant extracellular lipases from<i><fc>Y</fc>arrowia lipolytica</i> in <i><fc>S</fc>accharomyces cerevisiae</i>

Saccharomyces cerevisiae cannot produce extracellular lipase and utilize low-cost lipid substrates. This study aimed to express extracellular lipase from Yarrowia lipolytica in S. cerevisiae, construct recombinant oily substrate consumer strains, and compare the roles of native and mutant Y. lipolytica extracellular lipases in S. cerevisiae. The LIP2 gene of Y. lipolytica DSM3286 and its mutant Y. lipolytica U6 were isolated and cloned by expression vector in S. cerevisiae. New recombinant S. cerevisiae strains FDS100 containing the native LIP2 gene, and FDS101 containing the mutant LIP2 gene were produced 10 and 15 U ml-1 extracellular lipase respectively, on a production medium containing olive oil. New recombinant S. cerevisiae strains produce acceptable amount of extracellular lipase in comparison with Y. lipolytica wild-type strains. These strains can utilize olive oil and lipids as low-cost substrates to produce bioethanol, single cell protein and other biotechnologically valuable products. The recombinant S. cerevisiae strain with mutant LIP2 produced lipase with 1.5-fold higher activity. The LIP2 gene of Y. lipolytica was expressed in S. cerevisiae as a heterologous protein without any modifications. Strong components of the Y. lipolytica expression/secretion system could be used for high-level production of recombinant proteins in S. cerevisiae.