Miracle-dz/UniFAR-FTUs huggingface dataset:
Hyperarousal-state of Insomnia Disorder in Wake-resting State Quantitative Electroencephalography

Objective Insomnia is associated with elevated high-frequency electroencephalogram power in the waking state. Although affective symptoms (e.g., depression and anxiety) are commonly comorbid with insomnia, few reports distinguished objective sleep disturbance from affective symptoms. In this study, we investigated whether daytime electroencephalographic activity explains insomnia, even after controlling for the effects of affective symptoms. Methods A total of 107 participants were divided into the insomnia disorder (n = 58) and healthy control (n = 49) groups using the Mini-International Neuropsychiatric Interview and diagnostic criteria for insomnia disorder. The participants underwent daytime resting-state electroencephalography sessions (64 channels, eye-closed). Results The insomnia group showed higher levels of anxiety, depression, and insomnia than the healthy group, as well as increased beta [t(105) = −2.56, p = 0.012] and gamma [t(105) = −2.44, p = 0.016] spectra. Among all participants, insomnia symptoms positively correlated with the intensity of beta (r = 0.28, p < 0.01) and gamma (r = 0.25, p < 0.05) spectra. Through hierarchical multiple regression, the beta power showed the additional ability to predict insomnia symptoms beyond the effect of anxiety (ΔR2 = 0.041, p = 0.018). Conclusion Our results showed a significant relationship between beta electroencephalographic activity and insomnia symptoms, after adjusting for other clinical correlates, and serve as further evidence for the hyperarousal theory of insomnia. Moreover, resting-state quantitative electroencephalography may be a supplementary tool to assess insomnia.
Congenital Central Hypoventilation Syndrome: Diagnosis and Long-Term Ventilatory Outcomes

Background: Congenital central hypoventilation syndrome (CCHS), a rare disease caused by variants in the paired-like homeobox 2B (PHOX2B) gene, affects regulation of respiration necessitating lifelong assisted ventilation (AV). Most patients require full-time AV during infancy and some patients may sustain adequate spontaneous ventilation during wakefulness and change AV modalities at a later age. The aims of this study were to assess the changes in duration and modalities of AV, long-term respiratory outcomes, and to correlate them with PHOX2B genotypes. Methods: We conducted a retrospective study of patients with CCHS treated at our institution between January 1997 and May 2022. Results analyzed included: clinical presentation, PHOX2B genotype, modality and duration of AV at diagnosis and follow-up, survival, and transition to adult care. Results: We identified 30 patients with CCHS—8 with PHOX2B nonpolyalanine repeat mutations (NPARMs), 21 with polyalanine repeat mutations (PARMs), and 1 with unknown PHOX2B genotype. The median age at presentation was 0.25 months (IQR 0.1-0.7 months). At diagnosis of CCHS, 24 (80%) patients required continuous AV and 28 (93%) received AV via tracheostomy. Twenty-six patients required sleep-only AV at a median age of 9 months (IQR 6-14 months). Nine patients requiring sleep-only AV underwent tracheostomy decannulation at a median age of 11.2 years (IQR 5.9-15.7 years) and used noninvasive positive pressure ventilation or diaphragm pacing. There was insufficient evidence to conclude that patients with PARMs and NPARMs differed by age at presentation (P = .39), tracheostomy (P = .06), and transition to sleep-only AV (P = .9). Six patients transitioned to adult care, 23 continued receiving pediatric care, and 1 patient died due to complications from Hirschsprung’s disease. Conclusion: Our study demonstrates prolonged survival and good long-term respiratory outcomes possibly related to the early diagnosis of CCHS, optimizing AV strategies, and multidisciplinary care. The increasing number of patients attaining adulthood highlights the necessity for multidisciplinary care for adults with CCHS.
Influence of the Planting Material and Spacing on the Growth and Yield of Garlic

Trials were conducted at Chaubattia to assess the practical utility of aerial bulbils of garlic. A considerable yield (96.10 q/ha) was obtained from the aerial bulbils when planted at closer distance (10 x 20 cm) which is the minimum spacing for weeding and hoeing. This was in comparison to the maximum (129.06 q/ha) obtained under the plantings with cloves at the same spacing. It, therefore, clearly indicated that the aerial bulbils can also be used as a planting material for garlic. Maximum net return was obtained from cloves followed by aerial bulbils when planted at closer spacing.
Unraveling the Influential Mechanisms of Social Commerce Overloads on User Disengagement: The Buffer Effect of Guanxi

Purpose Although user engagement has been paid increasing attention, the work on user disengagement is scarce, and little is understood about how overloads elicited by excessive social commerce activities affect user disengagement. Based on the stimulus-organism-response (SOR) framework and psychological reactance theory (PRT), the authors aimed to investigate the effects of social commerce overloads (SCOs) on user disengagement, its influential mechanism, and the buffer effect of guanxi. Participants and Methods The authors conducted an online survey to collect the data and then examined our theoretical model and hypotheses. This study employed SPSS 20.0 software and Amos 24.0 software to examine the hypothesized relationships and the model. Results Social commerce overloads (ie, information overload (IO), social overload (SO), and communication overload (CO)) positively impact reactance via inferences of manipulative intent (IMI) and compulsive perception (CP); IMI and CP positively influence reactance; IMI, CP, and reactance positively affect user disengagement (ie, neglecting behavior and blocking behavior); guanxi has the buffer effect on the relationship between IMI (CP) and user disengagement, negatively moderates the impacts of IMI on user disengagement (ie, neglecting behavior and blocking behavior), and negatively moderates the effects of CP on blocking behavior but not neglecting behavior. Conclusion The findings of this study contribute to the literature on PRT and user disengagement by displaying the effects of excessive social commerce activities on user disengagement and uncovering the buffer effect of guanxi, which can help social e-commerce practitioners better reduce the negative effect of social commerce overloads.
Modern Management and Diagnostics in HER2+ Breast Cancer with CNS Metastasis

Simple Summary HER2-positive breast cancer has an affinity for the central nervous system (CNS) manifested by metastases in both the brain parenchyma and the leptomeninges. The authors review the epidemiology of HER2-positive CNS metastases, risk factor, and prognosis herein. They also discuss available treatment options for these patients as well as treatments on the horizon. Abstract Patients with HER2-positive breast cancer have seen improved survival and outcomes over the past two decades. As patients live longer, the incidence of CNS metastases has increased in this population. The authors’ review outlines the most current data in HER2-positive brain and leptomeningeal metastases and discuss the current treatment paradigm in this disease. Up to 55% of HER2-positive breast cancer patients go on to experience CNS metastases. They may present with a variety of focal neurologic symptoms, such as speech changes or weakness, and may also have more diffuse symptoms related to high intracranial pressure, such as headaches, nausea, or vomiting. Treatment can include focal treatments, such as surgical resection or radiation (focal or whole-brain radiation), as well as systemic therapy options or even intrathecal therapy in the case of leptomeningeal disease. There have been multiple advancements in systemic therapy for these patients over the past few years, including the availability of tucatinib and trastuzumab-deruxtecan. Hope remains high as clinical trials for CNS metastases receive greater attention and as other HER2-directed methods are being studied in clinical trials with the goal of better outcomes for these patients.
Epidemiology and SARS-CoV-2 Infection Patterns among Youth Followed at a Large Los Angeles Health Network during 2020–2022: Clinical Presentation, Prevalent Strains, and Correlates of Disease Severity

Background: Outcomes of SARS CoV-2 infection in infants, children and young adults are reported less frequently than in older populations. The evolution of SARS-CoV-2 cases in LA County youths followed at a large health network in southern California over two years was evaluated. Methods: A prospective cohort study of patients aged 0–24 years diagnosed with COVID-19 was conducted. Demographics, age distribution, disease severity, circulating variants of concern (VOCs), and immunization rates were compared between first and second pandemic years. Logistic regression estimated odds ratios (OR) and 95% confidence intervals (CI) of factors associated with severe/critical COVID-19. Results: In total, 61,208 patients 0–24 years of age were tested for SARS-CoV-2 by polymerase chain reaction (PCR); 5263 positive patients (8.6%) with available data were identified between March 2020 and March 2022. In Year 1, 5.8% (1622/28,088) of youths tested positive, compared to 11% (3641/33,120) in Year 2 (p < 0.001). Most youths had mild/asymptomatic illness over two years. SARS-CoV-2 positivity was >12% across all age groups in the second half of Year 2, when Omicron prevailed. Pulmonary disease was associated with higher risk of severe COVID-19 in both years (OR: 2.4, 95% CI: 1.4–4.3, p = 0.002, Year 1; OR: 11.3, 95% CI: 4.3–29.6, Year 2, p < 0.001). Receipt of at least one COVID-19 vaccine dose was protective against severe COVID-19 (OR: 0.3, 95% CI: 0.11–0.80, p < 0.05). Conclusions: Despite different VOCs and higher rates of test positivity in Year 2 compared to Year 1, most youths with COVID-19 had asymptomatic/mild disease. Underlying pulmonary conditions increased the risk of severe COVID-19, while vaccination was highly protective against severe disease in youths.
The Uniformization Theorem

1 Harmonic functions 1.1. Throughout this section X denotes a connected Riemann surface, possibly noncompact. The open unit disk in C is denoted by D. A conformal disk in X centered at p ∈ X is a pair (z,D) where z is a holomorphic coordinate on X whose image contains the closed disk of radius r about the origin in C, z(p) = 0, and D = {q ∈ X : |z(q)| < r}. For a conformal disk (z,D) we abbreviate the average value of a function u on the boundary of D by by
ESTIMATION OF THE LARGER OF TWO NORMAL MEANS

Let Xi1, Xi2, …, Xin, i = 1, 2, be a pair of random samples from populations which are normally distributed with means θi, and common known variance τ2. The problem is to estimate the function φ(θ1, θ2) = maximum (θ1, θ2). In this paper we consider five different estimators (or sets of estimators) for φ(θ1, θ2) and evaluate their biases and mean square errors. The estimators are (i) φ(X1, X2), where Xi is the sample mean of the ith sample; (ii) the analogue of the Pitman estimator, i.e. the a posteriori expected value of φ(θ1, θ2) when the generalized prior distribution is the uniform distribution on two dimensional space; (iii) a class of estimators which are generalized Bayes with respect to generalized priors which are products of uniform and normal priors; (iv) hybrid estimators, i.e. those which estimate by (X1 + X2)/2 when |X1 – X2| is small, and estimate by φ(X1, X2) when |X1 − X2| is large; (v) maximum likelihood estimator. The bias and mean square errors for these estimators are tabled, graphed, .
Relevant components in regression

This paper treats definitions of "relevant components" in regression. A component is defined as a linear combination of the independent variables, and different requirements for such components to be "relevant" for the prediction problem are discussed. The relationship between the definitions is investigated and their relationship to various regression methods is discussed. A new regression method is proposed: restricted principal component regression, which is based on the concept of "relevant components". The theory is illustrated by examples.
Analgesic effect of adding calcitonin to bupivacaine in erector spine plane block for breast surgery, a double blind randomised study

ABSTRACT Background Surgery for breast malignancy is linked to severe perioperative discomfort. Pain management reduces the need for opioids and general anesthesia. The “erector spinae plane block” (ESPB) recently became an effective choice in this concern. Our trial assessed the effectiveness of calcitonin as an LA adjuvant in ESPB for pain control in patients underwent cancer breast surgery. Patients and Methods One hundred and thirty patients were randomly allocated into two groups, BC and B. BC group received ESPB with 20 mL of bupivacaine 0.25% in addition to 50 IU of calcitonin in 2 mL of saline, while the other group received the same bupivacaine dose in addition to saline (2 ml). Main outcome was time for first rescue analgesia. Secondary outcomes included 24-h total morphine consumption postoperatively, postoperative VAS scores, levels of inflammatory cytokines, total intraoperative fentanyl consumption, and side effects. Results The period before the first-time analgesia was required was extended (12.18 ± 4.969 h vs 6.60 ± 3.116 h, P < 0.001), with less postoperative opioid consumption in the BC group (6.40 ± 1.876 mg vs 7.74 ± 2.117 mg, P < 0.001). Pain scores and the number of patients who asked for painkillers after surgery were less in the BC group. Patients in the BC group had a significant decline in serum inflammatory cytokines (TNF-α, IL-6), while IL-10 showed a significant increase in the BC group (P < 0.001). Intraoperative fentanyl and postoperative adverse effects recorded were statistically comparable in the two studied groups. Conclusion The addition of calcitonin to bupivacaine in the ESPB block can give an extended analgesic effect with lower inflammatory cytokine indicators.
Morphological and Phylogenetic Characterisations Reveal Four New Species in Leptosphaeriaceae (Pleosporales, Dothideomycetes)

Leptosphaeriaceae is a widely distributed fungal family with diverse lifestyles. The family includes several genera that can be distinguished by morphology and molecular phylogenetic analysis. During our investigation of saprobic fungi on grasslands in Yunnan Province, China, four fungal taxa belonging to Leptosphaeriaceae associated with grasses were collected. Morphological observations and phylogenetic analyses of the combined SSU, LSU, ITS, tub2, and rpb2 loci based on maximum likelihood and Bayesian inference were used to reveal the taxonomic placement of these fungal taxa. This study introduces four new taxa, viz. Leptosphaeria yunnanensis, L. zhaotongensis, Paraleptosphaeria kunmingensis, and Plenodomus zhaotongensis. Colour photo plates, full descriptions, and a phylogenetic tree to show the placement of the new taxa are provided.
The Effect of Using Concept Mapping as a Pre-Writing Stage Strategy on Iraqi EFL College Students’ Achievement in Essay Writing

This study is an attempt to investigate the effect of using concept mapping as a prewriting strategy on Iraqi EFL college students’ achievement in essay writing. To fulfill the aims of the study, the researcher has adopted two null hypotheses. The first states that there is no statistically significant difference between the achievement mean scores of the students who are taught essay writing through concept mapping as a pre-writing strategy and those who are taught essay writing through the conventional way. The second hypothesis states that there is no statistically significant difference between the experimental group students’ achievement mean scores in the organization, content and quality of expressions in the pre and posttests. To achieve the aim of the study, a ten-week experiment was conducted using the pretest-posttest non-equivalent groups design. Two groups of 105 students were selected from the population of third year students/College of Education for Women-Department of English during the academic year (2013-2014). One group was selected as the experimental group (namely section B) and another group was selected as the control group (namely section C). Both students of the experimental and control groups were exposed to pre and posttests. Using the t-test for two independent samples, it is found that there is a statistically significant difference in favour of the experimental group; whereas, by using t-test for two dependent samples, it is found out that there is a significant development in the experimental group students’ achievement in organization, content and style and quality of expression. This indicates that using concept mapping as a prewriting strategy is more effective than the presentation- practice- production teaching or the Lecture Method teaching. Conclusions, recommendations and suggestions for further studies are put forward.
Associations between Green Space Surrounding Kindergartens and Hyperactivity Behaviors among Chinese Preschool Children

Background: Attention deficit hyperactivity disorder (ADHD) affects approximately 2–7% of children worldwide and has become a global public health concern. The health effects of green space on ADHD in young children are unclear. We investigated associations between school-surrounding greenness and hyperactivity behaviors in preschool children. Methods: We performed a cross-sectional analysis using data of 66,678 preschool children (mean age: 3.53 years) from an on-going cohort in Shenzhen, China. The greenness surrounding kindergartens was measured using satellite-derived Normalized Difference Vegetation Index (NDVI) values at buffers of 250 m, 500 m, and 1000 m. Children’s hyperactivity behaviors were measured using the validated Conners’ Parent Rating Scale-Revised. We used generalized linear mixed models to assess the associations of greenness exposure with hyperactivity behaviors with adjustment for a variety of covariates. Results: Exposure to higher school-surrounding greenness was associated with lower prevalence of hyperactivity behaviors. In fully adjusted models, the odds ratio of hyperactivity behaviors in relation to an IQR (0.1) increase in NDVI at the 250 m buffer was 0.91 [confidence interval (CI): 0.84,0.98]. Consistent results were observed for greenness at the 500 m and 1000 m buffers. The negative association between greenness and hyperactivity behaviors was more pronounced in boys than in girls. Conclusions: Our findings suggest that higher levels of school-surrounding green spaces are associated with a lower risk of hyperactivity behaviors in preschool children.
Algorithms for Mixture Models

Mixture models form one of the most fundamental classes of generative models for clustered data. Specific application examples include text classification problems, image segmentation and motion detection, collaborative filtering and many others. However, quite surprisingly, very little had been known about algorithms which have provable performance guarantees within the framework of mixture models. This is the topic we study in this work. Our contribution is twofold. First, for the canonical problem of separating mixtures of continuous distributions in the high-dimensional Euclidean space, we provide the first algorithm that can learn distributions with heavy tails, including those with infinite variance and expectation. We formulate necessary conditions and provide an algorithm which guarantees that the underlying mixture model can be learned by observing only polynomially many samples. We also show that for many classes of distributions, our separation conditions are necessary for any algorithm which guarantees accurate reconstruction. Second for the case of discrete mixture models we give an efficient polynomial time algorithm with provable performance guarantees. Recasting of our algorithm for the text classification problem immediately results in a very fast unsupervised learning method, with an excellent classification accuracy.
Children with Disabilities in Canada during the COVID-19 Pandemic: An Analysis of COVID-19 Policies through a Disability Rights Lens

Children with disabilities were especially vulnerable during the COVID-19 pandemic, and policies designed to mitigate its effects were limited in addressing their needs. We analyzed Canadian policies related to children with disabilities and their families during the COVID-19 pandemic to identify the extent to which these policies aligned with the United Nations Convention on the Rights of Persons with Disabilities (UN CRPD) and responded to their mental health needs by conducting a systematic collection of Canadian provincial/territorial policies produced during the pandemic, building a categorization dictionary based on the UN CRPD, using text mining, and thematic analysis to identify policies’ alignment with the UN CRPD and mental health supports. Mental health was addressed as a factor of importance in many policy documents, but specific interventions to promote or treat mental health were scarce. Most public health policies and recommendations are related to educational settings, demonstrating how public health for children with disabilities relies on education and community that may be out of the healthcare system and unavailable during extended periods of the pandemic. Policies often acknowledged the challenges faced by children with disabilities and their families but offered few mitigation strategies with limited considerations for human rights protection.
THE ORBITAL DYNAMICS ENVIRONMENT OF 433 EROS

The dynamical environment experienced by the NEARShoemaker spacecraft at Asteroid 433 Eros is discussed. From an orbital dynamics point of view the spacecraft was navigated in the most severely perturbed orbital environment (relative to the standard 2-body problem) ever experienced by a spacecraft. We discuss the regions relatively far from the asteroid, where solar effects are the dominant perturbation, and close to the asteroid, where the gravity field and rotation of Eros are most important. Analytical and numerical stability criterion and a qualitative approach to the description of orbital dynamics perturbations are derived and discussed. 1N avigation Model of Eros Environment During the course of its mission, the NEAR spacecraft was used as a probe to determine the force environment about Eros. This determination arose naturally from the navigation of the spacecraft, as precision estimates of the force environment are needed to predict, guide, and reconstruct the spacecraft trajectory [8]. There was also a strong scientifi ci nterest in the Eros force environment, as its gravity field and shape can be used to infer the distribution of mass density within the body [19]. The estimation of the asteroid’s force parameters involved the simultaneous processing of radiometric Doppler data and optical images of the asteroid’s surface. Altimetry measurements from the spacecraft to the asteroid were used in a post-processing mode to determine the asteroid’s shape. A complete and detailed description of the determination of the shape, gravity, and rotational state of Eros is provided in Miller et al. [10]. Af ew items of interest related to the measured models should be noted. First is that the internal mass density distribution of Eros seems remarkably homogenous. The main observed deviations from this homogeneity lie at the resolution limit of the gravity field determination, and