Miracle-dz/UniFAR-FTUs huggingface dataset:
THE IMMUNE SYSTEM AS A TARGET FOR ANTIBIOTICS

Grondel, J.L. , Gloudemans, A.G. M. and van Muiswinkel, W.B. , 1985. The influence of antibiotics on the immune system. II. Modulation of fish leukocyte responses in culture. Vet. Immunol. Immunopathol. , 9: 251-260. We report the immunomodulating effect of two tetracycline analogues (Oxytetracycline and doxycycline) on mitogenic and allogeneic stimulation of carp (Cyprinus aarpio) leukocytes in vitro. Both drugs interfered with ^-thymidine incorporation into the DNA of phytohaemagglutinin-stimulated pronephric leukocytes in a dose-dependent manner. Low concentrations of Oxytetracycline delayed the mitogenic response, but did not reduce it. In addition, several other antibiotics were tested for their possible interference with blastogenesis.
Chromatin Compaction by Human MeCP2 ASSEMBLY OF NOVEL SECONDARY CHROMATIN STRUCTURES IN THE ABSENCE OF DNA METHYLATION*

From the ‡Department of Biochemistry, University of Texas Health Science Center, San Antonio, Texas 78229-3900, the §Department of Biological Sciences, Marshall University, Huntington, West Virginia 25755, the ¶Department of Biology, University of Massachusetts, Amherst, Massachusetts 01003, and the Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia 30322
A Novel IkB Protein, IkB-z, Induced by Proinflammatory Stimuli, Negatively Regulates Nuclear Factor-kB in the Nuclei*

The transcription factor nuclear factor-kB (NF-kB) plays crucial roles in a wide variety of cellular functions and its activity is strictly regulated by cytosolic inhibitors known as IkBs. We here report a new member of the IkB protein family, IkB-z, harboring six ankyrin repeats at its carboxyl terminus. IkB-z mRNA is strongly induced after stimulation by lipopolysaccharide. The induction of IkB-z is also observed by stimulation with interleukin-1b but not by tumor necrosis factor-a. In contrast to cytosolic IkB-a, -b, and -e, the induced IkB-z localizes in the nucleus via its amino-terminal region, which shows no homology with other proteins. Transiently expressed IkB-z inhibits the NF-kB activity without affecting the nuclear translocation of NF-kB upon stimulation. The expressed IkB-z preferentially associates with the NF-kB subunit p50 rather than p65 and recombinant IkB-z proteins inhibit the DNA binding of the p65/p50 heterodimer and the p50/p50 homodimer. Thus, IkB-z negatively regulates NF-kB activity in the nucleus, possibly in order to prevent excessive inflammation. Moreover, transfection of IkB-z renders cells more susceptible to apoptosis induced by tumor necrosis factor-a. The proapoptotic activity of IkB-z further suggests that it might be one of key regulators for inflammation and other biologically relevant processes.
Sample taking for identifi cation of papilomavirus DNA: skills and knowledge

Objective: To establish the relationship between the knowledge and skills of health personnel in taking samples for the identifi cation of papillomavirus DNA. Methods: Cross-sectional study, conducted between March and June of 2017. Population of 313 people, the probabilistic sample was calculated considering a r = 0.306 expected, 95% confi dence, and power of 90%, which equated to 90 workers from 23 health centers. A knowledge test and checklist were administered to evaluate sampling skills, with the hybrid capture method (HPV-CH2 test). For data analysis, Pearson’s and the ANOVA correlation were used. Results: A correlation between knowledge and skills was found (r=0.438) (p<0.001). Regarding knowledge, there was no signifi cant difference in the means obtained from the three groups of participants (nurses vs. interns 3.27 p=0.557, physicians vs. nurses 2.17 p=0.852, physicians vs. interns 5.45 p=0.441). Regarding skills, there was no difference between the means obtained between physicians and interns Conclusion: There was a correlation between the knowledge and skills in taking samples for the identifi cation of papillomavirus DNA. There were no signifi cant differences in knowledge between the groups studied; but a difference in means for skills was found between physicians and interns. médicos vs. enfermeros 2,17 p=0,852 y médicos vs. practicantes 5,45 p=0,441). Respecto a las habilidades, no hubo diferencia en los promedios obtenidos entre médicos y enfermeros (4,27 p=0,388), ni entre enfermeros y practicantes (4,54 p=0,179), pero hubo diferencia entre médicos y practicantes (8,81 p=0,041). Conclusión: hubo correlación entre el conocimiento y las habilidades para tomar muestras para identifi car el ADN del papilomavirus. No hubo diferencias signifi cativas en el conocimiento entre los grupos estudiados, pero se encontró una diferencia con relación a las habilidades entre médicos y practicantes.
2016 Ventricular Tachyarrhythmia Onset Prediction Based on HRV and Genetic

3 Abstract Predicting onset of ventricular tachyarrhythmia provides opportunities to reduce casualties due to sudden cardiac death. However, the prediction accuracy still needs improvement. Therefore, we aim to propose a method that can predict the onset of tachyarrhythmia events with improved accuracy based on heart rate variability and Support Vector Machine classifier. Fifty percent of sample data from standard database was used to train the classifier, and the remainder was used to verify the performance. Five minutes RR intervals immediately prior to tachyarrhythmia event from each sample data was cropped for ectopic beat correction and then converted to heart rate. Extraction of time domain, spectral, non-linear and bispectrum features were performed subsequently. Furthermore, genetic algorithm was used to simultaneously optimize the feature subset and classifier parameters. With the optimization, prediction accuracy of our proposed method able to outperform previous works with 77.94%, 80.88% and 79.41 % for sensitivity, specificity and accuracy
VIDEOCONFERENCES. SYSTEMATIZATION AND EXPERIMENTS IN TELEMEDICINE*

Telemedicine refers to the delivery of health care services over a distance. Videoconference is one of the different modalities of telemedicine, allowing real-time interaction. The present study is aimed at describing videoconference systems in a simplified way, focusing on their application in telemedicine. Videoconference involves the necessity of equipment for audio and video capture and reproduction, besides a communication link for connection with similar equipment through ISDN (integrated services digital network) or IP (internet protocol). Video and audio quality is essential for the success of a videoconference. Experiments using videoconferencing equipment in radiology and other fields of medicine are a reality at international level. In Brazil, reports account for some isolated initiatives in this field, most of them involving universities networks. Besides its remarkable impact on costs of medical care delivery for the population, videoconference represents an invaluable tool for physicians in their education and knowledge updating.
Implementasi Algoritma Perturb and Observe untuk Mengoptimasi Daya Keluaran Solar Cell Menggunakan MPPT di Laboratorium Energi Baru Terbarukan

Energi yang dihasilkan oleh sel surya sangat bervariasi dan sangat tergantung pada kondisi cuaca. Untuk mengoptimasinya digunakan maximum power point. Penelitian ini mengimplementasikan algoritma Perturb and Observe pada Maximum Power Point Tracker (MPPT) sebagai kontroller untuk pembangkitan energi surya. Sistem dibangun menggunakan Arduino Uno R3 untuk mengekstraksi daya maksimum panel surya. Microcontroller ini mengontrol DC buck converter dan digunakan untuk charging baterai 6V. Metode ini beroperasi dengan memberi perturbing tegangan atau arus terminal array dan membandingkan daya yang dihasilkan dengan output panel surya. Diperlukan perturbing yang sesuai untuk mendapatkan nilai optimasi yang tepat. Validasi dari panel surya menggunakan metode yang diusulkan pada MPPT-nya memberikan performansi yang lebih baik dibuktikan pada nilai daya dan tegangannya. Menggunakan parameter perturbation 0.1, MPPT mampu mengoptimasi daya ouput panel surya sebesar 24.49 W dengan beban 5 ? dan nilai irradiasi 523 W/m2 dibandingkan dengan metode konvensional dengan beban sama dan nilai irradiasi sebesar 527 W/m2 yang menghasilkan daya keluaran 15.37 W
The spatial distribution of RGD and BMP-2 mimetic peptides at the subcellular scale modulates human mesenchymal stem cells osteogenesis

Engineering artificial extracellular matrices (ECMs), based on the biomimicry of the spatial distribution of proteins and growth factors within their native microenvironment, is of great importance for understanding mechanisms of bone tissue regeneration. Herein, photolithography is used to decorate glass surfaces with subcellular patterns of RGD and BMP-2 ligands; two mimetic peptides recognized to be involved in stem cells osteogenesis. The biological relevance of well-defined RGD and BMP-2 patterned surfaces is evaluated by investigating the differentiation of human mesenchymal stem cells (hMSCs) into osteoblasts, in the absence of induction media. The extent of hMSCs differentiation is revealed to be dependent on both the pattern shape and the ligand type. Indeed, the spatial distribution of BMP-2, but not RGD peptide, significantly enhances the extent of hMSCs differentiation, suggesting that geometric cues guide stem cells specification into specialized cells in a ligand type dependent manner. Such cell culture models provide an interesting tool to investigate how stem cells perceive and respond to their microenvironment and may contribute to the development of next-generation biomaterials capable of producing clinically relevant volume of bone tissue.
The subjective judgm ent of the elastic and plastic properties of soft bodies; the “ differential thresholds” for viscosities and compression moduli

Wallis, E. S. and Fernholz, E . 1936 J . Am er. Chem. 58, 2446. W illstatter, R. and Mieg, W . 1907 Liebigs A nn. 355, 1. W illstatter, R. and Page, H. J. 1914 Liebigs Ann. 404, 237. W illstatter, R. and Stoll 1913 Untersuchungen uber CBerlin: J. Springer. Windaus, A. and H auth, A. 1906 Ber. dtsch. chem. Ges. 39, 4378. Zechmeister, L. 1934 Carotinoide. Berlin: J. Springer. Zechmeister, L. and Tuzson 1938 Biochem. J . 32, 1305. -------1939 Ber. dtsch. chem. Ges. 72, 1340. Zopf, W. 1895 Biol. Zbl. 15, 417.
Food Production Diversity and Diet Diversification in Rural and Urban area of Iran

The food security paradigm shifted from diet quant ity to diet quality and consumption of a satisfactory amount of micronutrie nts around the world. Low dietary diversification and imbalance consumption of food g roups are the main characteristics of Iranian households. Food production diversity ca n be a significant determinant of dietary diversity in developing countries such as I ran. Thus, this research tries to examine the impact of food production diversity alo ngside the socioeconomic and sociodemographic determinants on dietary diversity in rural and urban areas of the country. For this aim, a panel data set is construc ted based on all the available data in rural and urban areas of 31 provinces of Iran from 2011 to 2016 and panel quantile regression applied to investigate the impact of the control variables. The main results indicate that food production diversity, household income, the share of food in household expenditure, literacy rate have a positiv e and significant impact on the dietary diversity in rural and urban regions of the country. Moreover, the food price index has a negative and significant effect on diet ary diversity in both regions. Finally, the age of head of household and family size only h as a negative impact on diet diversification in rural areas. According to these results, encouraging small farmers to change their production patterns to a more diverse pattern in a short time, and pursuing multidimensional approaches such as the pr omotion of agricultural value chain should be considered by policymakers to impro ve the dietary diversity in rural and urban areas. Furthermore, the establishment of rural retirement found and redistribution of current income subsidy can help t he elderly and extended family in rural areas to enhance their diet quality. Finally, design a price monitoring approach alongside a flexible trade strategy to manage the f ood market prices can help households to consume the appropriate diet with eno ugh micronutrients.
HOW DOES THE DIVERSITY OF THE BOARD MEMBERS AFFECT FIRM PERFORMANCE? THE CASE OF BRAZIL

This research investigates the relationship between the diversity on the composition of Board of Directors and the financial performance of Brazilian listed companies in BOVESPA, in a corporate segment called “Novo Mercado”. Despite being an increasingly studied topic abroad, Brazil has limited studies in diversity when compared with other countries. In a global level, most of the studies regarding this topic are focused on the gender composition of the Board. In this article, diversity is measured by four variables: gender, age, education and independence (or not) of the Board members. Analyzing a sample of 119 companies in Brazil, 967 individuals as board members, covering the period of 2013-2015, this quantitative study has as its core method an ordinary least squares (OLS) for estimating the parameters in a linear regression model, using as controls variables board size, industry (economic segment), the types of capital of listed companies, categorizing them as State, Private and Private Holding. In accordance with the theory, the research finds that a more diverse board (in terms of gender) has positive impact in the financial performance, measured by Return over Assets. In the other hand, the results show that diversity in terms of education and age has a negative impact in terms of ROA. In addition to the overall contribution to the discussion of diversity on Boards of Directors, the findings of the research may help shareholders, stakeholders and policy makers using such knowledge to use the Board more efficiently and strategically.
EFFECT OF FEEDING OLIVE BY-PRODUCTS ON CERTAIN BLOOD PARAMETERS AND SERUM ENZYME ACTIVITIES OF FATTENING RABBITS

The effect of feeding different levels (10 and 20%) of dehydrated olive cake pulp on certain blood parameters and on the catalytic activity of serum enzymes was studied in fattening rabbits. A total of 60 rabbits were divided into a control group (C) and two experimental groups (E 1 , E 2 ), each comprising 10 males and 10 females. Rabbits of Group C received no dehydrated olive cake pulp in their diet, while rabbits of Group E 1 and Group E 2 were fed 10% and 20% dehydrated olive cake pulp, respectively. After Day 56 of the experiment, blood samples were obtained by cardiac puncture and certain blood parameters as well as the catalytic activity of serum enzymes were determined. Following the experimental feeding period no significant differences were found between Group C and Groups E 1 and E 2 in red blood cell (RBC) and white blood cell (WBC) count, haemoglobin concentration and haematocrit value. Similarly, after 56 days of experimental fattening no significant differences were found between the control group and the experimental groups in the catalytic activity of the serum enzymes alkaline phosphatase (AP), aspartate aminotransferase (AST), gamma-glutamyltransferase (GGT), and lactate dehydrogenase (LDH). However, Group E 2 rabbits manifested a significantly higher alanine aminotransferase (ALT) activity in the serum than did rabbits of Group E 1 . The results in-dicate that the inclusion of dehydrated olive cake pulp in the diet at the rate of 10% or 20% caused no changes in the investigated blood parameters and serum enzyme activities of fattening rabbits.
High-Frequency Trading and its Impact on Market Liquidity: A Review of Literature 1

High-frequency trading (HFT) has been dominating the activity in developed financial markets in the last two decades. Despite its recent formation, the literature on the impacts of HFT on financial markets and participants is broad. However, there are ongoing debates and unanswered questions within many subtopics. We survey through the research towards HFT effects on liquidity in an attempt to explain the coexistence of evidence regarding both the positive and the negative impacts of HFT. We name two main factors leading to mixed results. Former concerns the negative market conditions such as intraday shocks, through which HFT trading patterns may sharply change. Latter regards the certain characteristics of HFT liquidity provision with the potential to present externalities for the market.
Human Actin Genes Are Single Copy for a-Skeletal and cx-Cardiac Actin but Multicopy for P-and y-Cytoskeletal Genes : 3 ' Untranslated Regions Are Isotype Specific but Are Conserved in Evolution

We have constructed isotype-specific subclones from the 3' untranslated regions of a-skeletal, a-cardiac, p-cytoskeletal, and y-cytoskeletal actin cDNAs. These clones have been used as hybridization probes to assay the number and organization of these actin isotypes in the human genome. Hybridization of these probes to human genomic actin clones (Engel et al., Proc. Natl. Acad. Sci. U.S.A. 78:4674-4678, 1981; Engel et al., Mol. Cell. Biol. 2:674-684, 1982) has allowed the unambiguous assignment of the genomic clones to isotypically defined actin subfamilies. In addition, only one isotype-specific probe hybridizes to each actincontaining gene, with a single exception. This result suggests that the multiple actin genes in the human genome are not closely linked. Genomic DNA blots probed with these subclones under stringent conditions demonstrate that the askeletal and a-cardiac muscle actin genes are single copy, whereas the cytoskeletal actins, Pi and y, are present in multiple copies in the human genome. Most of the actin genes of other mammals are cytoplasmic as well. These observations have important implications for the evolution of multigene families.
Promoción de la efectividad de las Organizaciones de Economía Social: Una propuesta basada en la gestión de la identidad

Resumen. En este artículo, proponemos que las organizaciones de economía social (OES) pueden mejorar su efectividad si sus líderes desarrollan una estrategia dirigida a la gestión de la identidad organizacional, es decir, si consiguen involucrarse en la creación de una identidad laboral. Tras situar esta misión en el centro de la efectividad de las OES, identificamos cuatro funciones de la identidad laboral fundamentales a la hora de mejorar el rendimiento laboral: a) la identidad como lente y brújula; b) la identidad como recurso; c) la gestión de múltiples identidades; y d) la identidad como fuente de identificación. Finalizamos con sugerencias para que los líderes de OES desarrollen prácticas, que enfatizando en las cuatro funciones de la identidad laboral descritas anteriormente, aprovechen la identidad organizacional como un valioso activo que pueda ser utilizado por todos aquellos que sitúan el beneficio colectivo por encima de cualquier otro ingreso obtenido a través de la acción organizada. Abstract. In this article, we propose that social economy organisations (SEOs) can improve their effectiveness if their leaders create a strategy for the management of organisational identity, that is, if they get involved in identity work. After placing the mission at the core of the effectiveness of SEOs, we identified four main focuses of identity work that we see as fundamental to promote the performance of these organisations: a) identity as a lens and as a compass; b) identity as a resource; c) management of multiple identities; d) identity as source of identification. We end with the suggestion of SEOs leaders' development practices that, by emphasizing these four lines of identity work, take advantage of organisational identity, a valuable asset to be used by all those who place the collective benefit above all other income obtained through organised action.
Formation Events in an Urban Environment

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Phenotypic characterization and weight prediction of crossbred Dorper × Santa Inês ewes Caracterização fenotípica e predição do peso de ovelhas mestiças Dorper × Santa Inês

The objective was to determine zoometric indices, correlate, and predict body weight based on the biometric measurements of F1 Dorper × Santa Inês (F1 D × SI) ewes created extensively. Were 25 F1 D × SI sheep monitored, with ages varying from 2 to 9 months. Body weight, thoracic perimeter, belly perimeter, body length, withers height, rump height, rump width, and rump length were measured on a monthly basis and zoometric indices were estimated from them. Descriptive data analysis, Pearson's correlation, and regression analysis were performed. The biometric measurements and zoometric indices of F1 D × SI ewes indicate an animal of aptitude for cutting, with good conformation. In addition, they demonstrate favorable aspects for reproduction, a fundamental characteristic in the selection of matrices. Body weight has a high and positive correlation for all characteristics analyzed, with values ranging from 0.74 of the rump length to 0.88 of the thoracic perimeter. The regressions for all biometric measurements were highly significant (P <0.0001) with an emphasis on the thoracic perimeter that has the highest coefficient of determination (R2 = 0.77), the other measures presented below 0.70. It was concluded that F1 Dorper × Santa Inês ewes have characteristics for meat production and for reproduction. Also, of the biometric measurements, the thoracic perimeter can be used to predict the body weight of F1 Dorper × Santa Inês ewes.
EMBODY MOEMA: THE FEMALE BODY IN THE TIME-SPACE OF (RE) PRODUCTION OF BRAZIL AS A COLONY

Moema is an iconic character in the epic poem “Caramuru” written by José de Santa Rita Durão in 1781. This body that transforms itself continuously in many artistic manifestations, whether in literature, in historical narratives or in its manifestations in painting and sculpture during nineteenth century, has traces of the theme of Indianism, as well as of death in water, romantic death and the theme of the female nude. All of them are related with issues that concern aspects of the brutal process of (re) production of Brazil as a colony. Corporear Moema is an invitation to think about the female body and dynamics proper to the transition to the Modern Era. The critical analysis brings a rereading of the character to debate the role of the female body in the transition to capitalist society.