Miracle-dz/UniFAR-FTUs huggingface dataset:
Progression-Free Survival, Prognostic Factors, and Surgical Outcome of Spheno-Orbital Meningiomas

Objective Spheno-orbital meningiomas (SOM) are rare intracranial tumors that arise at the sphenoid wing. These tumors can invade important neurovascular structures making radical resection difficult, while residual tumors often lead to recurrence. The purpose of this study was to evaluate prognostic factors influencing the recurrence and progression-free survival (PFS) rates of spheno-orbital meningiomas, with a particular focus on the role of surgery and postoperative radiotherapy. Methods Between 2000 and March 2020, 65 cases of spheno-orbital meningioma were included, of which 50 cases underwent surgical treatment alone, and 15 cases underwent resection and radiotherapy. A Kaplan-Meier analysis was performed to provide median point estimates and PFS rates; further, Cox regression analysis was used to identify significant factors associated with treatment. Results Gross total resection significantly reduced the risk of recurrence (p-value = 0.0062). There was no significant benefit for progression-free survival after postoperative radiotherapy (p-value = 0.42). Additionally, spheno-orbital meningiomas with an invasion of the cavernous sinus and intraconal invasion showed significantly worse PFS compared to other locations (p-value = 0.017). Conclusion The maximal safe resection remains the most important prognostic factor associated with lower recurrence rates and longer PFS in patients with spheno-orbital meningioma. The invasion of the cavernous sinus and intraconal invasion was an independent factor associated with worse PFS. Patients with postoperative high-precision radiotherapy did not show significantly better PFS due to the small number of patients.
Overexpression of Interferon-Inducible Protein 16 Promotes Progression of Human Pancreatic Adenocarcinoma Through Interleukin-1β-Induced Tumor-Associated Macrophage Infiltration in the Tumor Microenvironment

Activation of inflammasomes has been reported in human pancreatic adenocarcinoma (PAAD); however, the expression pattern and functional role of inflammasome-related proteins in PAAD have yet to be identified. In this study, we systemically examined the expression and role of different inflammasome proteins by retrieving human expression data. Several genes were found to be differentially expressed; however, only interferon-inducible protein 16 (IFI16) expression was found to be adversely correlated with the overall survival of PAAD patients. Overexpression of IFI16 significantly promoted tumor growth, increased tumor size and weight in the experimental PAAD model of mice, and specifically increased the population of tumor-associated macrophages (TAMs) in the tumor microenvironment. Depletion of TAMs by injection of liposome clodronate attenuated the IFI16 overexpression-induced tumor growth in PAAD. In vitro treatment of conditioned medium from IFI16-overexpressing PAAD cells induced maturation, proliferation, and migration of bone marrow-derived monocytes, suggesting that IFI16 overexpression resulted in cytokine secretion that favored the TAM population. Further analysis suggested that IFI16 overexpression activated inflammasomes, thereby increasing the release of IL-1β. Neutralization of IL-1β attenuated TAM maturation, proliferation, and migration induced by the conditioned medium from IFI16-overexpressing PAAD cells. Additionally, knockdown of IFI16 could significantly potentiate gemcitabine treatment in PAAD, which may be associated with the reduced infiltration of TAMs in the tumor microenvironment. The findings of our study shed light on the role of IFI16 as a potential therapeutic target for PAAD.
Children’s Pronoun Interpretation Problems Are Related to Theory of Mind and Inhibition, But Not Working Memory

In several languages, including English and Dutch, children’s acquisition of the interpretation of object pronouns (e.g., him) is delayed compared to that of reflexives (e.g., himself). Various syntactic and pragmatic explanations have been proposed to account for this delay in children’s acquisition of pronoun interpretation. This study aims to provide more insight into this delay by investigating potential cognitive mechanisms underlying this delay. Dutch-speaking children between 6 and 12 years old with autism spectrum disorder (ASD; n = 47), attention-deficit/hyperactivity disorder (ADHD; n = 36) or typical development (TD; n = 38) were tested on their interpretation and production of object pronouns and reflexives and on theory of mind, working memory, and response inhibition. It was found that all three groups of children had difficulty with pronoun interpretation and that their performance on pronoun interpretation was associated with theory of mind and inhibition. These findings support an explanation of object pronoun interpretation in terms of perspective taking, according to which listeners need to consider the speaker’s perspective in order to block coreference between the object pronoun and the subject of the same sentence. Unlike what is predicted by alternative theoretical accounts, performance on pronoun interpretation was not associated with working memory, and the children made virtually no errors in their production of object pronouns. As the difficulties with pronoun interpretation were similar for children with ASD, children with ADHD and typically developing children, this suggests that certain types of perspective taking are unaffected in children with ASD and ADHD.
Love Forgiveness and Subjective Well-Being in Chinese College Students: The Mediating Role of Interpersonal Relationships

Love forgiveness is categorized as forgiveness in a specific relationship, which is the tendency of individuals to forgive the objects of their interpersonal relationships. We investigated 831 undergraduate students in China with a love forgiveness questionnaire, a subjective well-being questionnaire and an interpersonal relationship comprehensive diagnostic, including demographic variables. Students of different genders and grades showed significant differences across the three questionnaires. There were significant correlations between love forgiveness, interpersonal relationships, and subjective well-being of Chinese college students. Interpersonal relationships played an intermediary role between love forgiveness and subjective well-being of Chinese college students. Specifically, whereas Chinese college students’ love forgiveness could directly promote the improvement of subjective well-being, love forgiveness could also indirectly improve subjective well-being through interpersonal relationships. The mediating effect of interpersonal relationships between love forgiveness and subjective well-being accounted for 40.52% of the total effect. This provides a new way of thinking for psychological counselors to approach the intimate relationship problems of college students.
Rethinking the Epidemiogenic Power of Modern Western Societies

In less than a year, COVID-19 has imposed itself as one of the major health crises in the history of Western democracies although, as zoonotic diseases go, it is not especially deadly, nor are its symptoms especially terrifying (Harvard Health, 2020; Ioannidis, 2020). Faced with the spread of COVID-19, one of the most noticeable reactions of governments have been to impose lock-downs and important restrictions on freedom of movement and of association. These radical decisions caused such severe negative externalities (unemployment, poverty, inequality, loneliness, anxiety, depression, violence and the loss of schooling for millions of children) that they can only be temporary (Altman, 2020; Arpino et al., 2020; Banks, Karjalainen, and Propper 2020; Benke et al., 2020; Bonaccorsi et al., 2020; Czymara 2020; Green 2020; Grover et al., 2020; Martin et al., 2020; Usher et al., 2020; Fountoulakis et al., 2021). Such unparalleled restraints in peace-time were explicitly conceived as temporary measures to control, or mitigate, the spread of the epidemic while waiting for an effective and safe vaccine to be developed (See for instance Stella Kyriakides, EU commissioner for health and food safety, declaration on April 2020 Day, 2020). Even softer measures, such as social distancing and mask-wearing, were seen as ancillary to the main weapon—vaccination—and the assumption was that they had no relevance to healthcare in “normal” times. Thanks to an unpreceded pharmacological effort, the development and roll-out of a variety of safe, effective vaccines against COVID 19 has occurred, offering concrete means to end this crisis (Zimmer et al., 2020). Nonetheless, these pharmacological solutions should not prevent the consideration of those factors, endogenous to our societies, which helped to catalize this pandemic. Indeed, this paper argues, epidemics reflect a combination of exogenous and endogenous factors. Attention only to the former risks underestimating what we call ’the epidemicogenic’ dimensions of our society, at the risk of leaving us yet more vulnerable to destructive epidemics in future.
Influence of the Extrapallial Fluid of Pinctada fucata on the Crystallization of Calcium Carbonate and Shell Biomineralization

Extrapallial fluid (EPF) is located between the shell and the mantle, and it is believed to play key roles in shell biomineralization in Pinctada fucata. However, few studies have been performed on the biomineralization effect of EPF. In this work, CaCO3 crystallization experiments showed that EPF proteins could not only control the morphology but also regulate the phase transition of calcium carbonate through the different proteins specific binding to calcite or aragonite. In crystal growth inhibition experiments, when the final concentration of CaCl2 and NaHCO3 reduced from 50 to 5 mM, the function of EPF proteins (50 μg/mL) transferred from significantly improving over the number of CaCO3 crystals (448 ± 28) upon the control (128 ± 20) to inhibiting the precipitation of CaCO3. The precipitation rate of CaCO3 was also inhibited by EPF proteins. In vivo, once EPF was extracted daily for 20 days, the nacre platelet in the nacreous layer was disturbed, and calcite deposited randomly due to the reduction of.
The Effect of Different Exercise Training Types on Functionality in Older Fallers

Background: Fall is one of the most common geriatric syndromes in the elderly population. It is important to determine the most effective exercise training in elderly individuals who are at risk of falling. Aim: To investigate the effects of different exercise trainings on functionality in older fallers. Method: A total of 30 older adults, 16 females and 14 males, were enrolled in this randomized controlled trial. The older adults were divided into 3 groups: vestibular exercise (VE), posturography balance exercise (PBE), and square step exercise (SSE) groups. All groups received VE training. Sensory Organization Test (SOT), Adaptation Test (ADT), Fall Efficacy Scale (FES), Montreal Cognitive Assessment (MoCA), Vestibular Disorders Activities of Daily Life Scale (VADL), and the World Health Organization Quality of Life Scale–Older Adults Module (WHOQOL-Old) were administered before and at the end of the 24 training sessions. Results: The MoCA and the composite balance score of the SOT were improved in the PBE and SSE groups and the FES in all groups. According to multiple comparison analyses, toes up in the VE and PBE groups, toes down of the ADT in the PBE group, VADL in the PBE and SSE groups, the WHOQOL-Old in all groups significantly improved (P < .010). Conclusion: VE training alone is not sufficient for older fallers. A combination of PBE and SSE training, which was applied 3 times a week for 8 weeks, was more effective in improving functionality in older fallers.
Social Validity of an Early Intervention Online Professional Development Program

This article presents findings from an online early intervention orientation program developed to provide one state with an economical and systematic means for onboarding new early intervention providers, administrators, and service coordinators. The quantitative findings suggest the courses were a successful method of delivering training to participants, the courses were perceived to achieve their intended objectives, and the courses had high social validity in terms of ease of use and content of the courses. The qualitative findings revealed participants' plans for putting course content into practice. Findings suggest that online course delivery could be a viable and efficient means of providing early intervention orientation to a statewide network. The design of the courses and alignment with adult learning characteristics is discussed. Potential limitations and contributions to the field of early intervention are included.
Modeling Media Exposure, Appearance-Related Social Comaparison, Thin-Ideal Internalization, Body Image Disturbance And Academic Achievement Of Female University Students

There is extensive research where social, economic and interpersonal factors influence was investigated in the relationship of academic achievement. However, the studies where social pressure induces via media exposure on students’ academic achievement are scant. Rare studies investigate the social-cultural, socio-psychological, media and marketing constructs that influence academic achievement. This study investigates the sequential mediating effect of appearance-related social comparison, thin-ideal internalization, and body image disturbance in the relationship between media exposure and female university students’ academic achievement in Punjab, Pakistan. Multistage cluster random sampling technique was used for data collection for sampling frame. It is necessary to develop a sampling frame because the population was unknown. The study based on the cross-sectional survey was conducted with 1322 female students across Punjab to develop the sampling frame. Out of 1322 for the final sample, 504 questionnaires were randomly selected using the SPSS random value selection option. However, 20 questionnaires were removed from the sample because of missing values and outliers and a total of 484 survey questionnaires were used for data analysis. Two-stage structural equation modeling is used to measure the causal relationship among constructs. In the first stage, constructs validity and reliability were measured with confirmatory factor analysis. In the second stage, the structural model measures the causal relationship. All the direct hypotheses are statistically significant. Whereas appearance-related social comparison and thin-ideal internalization fully mediate the relationship between media exposure and body image disturbance. Moreover, body image disturbance partially mediates the relationship between appearance-related social comparison and academic achievement and thin-ideal internalization and academic achievement. Findings revealed that greater exposure to media disturbs body image and eventually, female students affect their academic performance.
Association between Dietary behaviours and Dental Fluorosis- a Retrospective study

Dental fluorosis is considered a major public health problem. Consumption of excess fluoride will lead to conditions like skeletal fluorosis and dental fluorosis. The aim of this study is to determine the association between dietary intake and fluorosis. The present study was conducted among patients who had reported to Saveetha Dental College, from the time period of June 2019 to March 2020. Case records of about 15,000 patients were reviewed and 561 patients were recruited who fulfilled the inclusion and exclusion criteria.Patients with dental fluorosis were included in the study. Patient age ,gender and the diet history and dean fluorosis index score were collected from the case records.Descriptive statistics, cross tabulation and chi-square test were done by SPSS IBM software 20.0. The results of the study showed that 49% of fluorosis patients are with a vegetarian diet and 51% of fluorosis patients are with a mixed diet. In patients with mixed diets the severity of fluorosis was slightly higher compared to vegetarian diet, with a Dean’s fluorosis index score of 4 severe (5.3%). However it is statistically not significant. [Pearson’s Chi Square value: 4.685 df = 4, p value = 0.321 (>0.05)] Within the limits of the study no significant association was found between diet and fluorosis,however severity of fluorosis in mixed diet seems to be higher.
Coordinating If s

Accounting for the behavior of conjoined and disjoined if-clauses is not easy for standard theories of conditionals that treat if as either an operator or restrictor. In this paper, I discuss four observations about coordinated if-clauses, and motivate a semantics for conditionals that reorients the compositional structure of the restrictor theory. On my proposal, if-clauses provide restrictions on modal domains, but they do so by way of a higher type intermediary—a set of propositions—that is collapsed by the modal. I argue that combining this view with an independently plausible type-shifting operation applied to or and and predicts the range of data we find for conditionals with coordinated if-clauses. An overlooked fact about conditional clauses is that they can be coordinated by sentential connectives like and and or: (1) If John draws a gold coin or if John draws a silver coin, he will win. (2) If John draws a gold coin and if John draws a silver coin, he will win. Coordinated if -clauses like these raise problems for standard compositional implementations of operator and restrictor theories of conditionals. I argue instead for a view on which if -clauses provide an element (a set of propositions) that is used to restrict modal domains. In §1, I sketch a pattern of data involving coordinated if s that raises a challenge to standard theories of conditionals. In §2, I show how my compositional reformulation of the restrictor theory predicts the behavior of such conditionals with coordinated if clauses. In §3, I contrast my view with the dynamic theory of Starr (2014) and the plural description theory of Santorio (2018). The latter each make some correct predictions about the meanings of coordinated if -clauses; however, I argue that these theories fail to accommodate the full range of data about such conditionals. © The Author(s) 2021. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com D ow naded rom http/academ ic.p.com /jos/artic/2/341/6279440 by jusdkhoo@ gm a.com on 29 M ay 2021
Prevalence of Root Caries among patients visiting a Private Dental Hospital- A Retrospective study

Dental root caries have received a great deal of attention in the last few years. It can occur as a Primary or Secondary lesion and diagnosis, access and treatment are different than coronal caries. Early detection of root caries may help in tooth retention for longer years. But, there have been too few studies to define it’s natural history, it’s distribution in a population and associated factors. Thus, The aim of the study was to evaluate the prevalence of root caries and their associated factors among patients visiting private dental college. The clinical records of 1911 patients with root caries were evaluated. Date of age, gender, tooth with root caries were obtained from the records of the dental hospitals. The data was analysed using SPSS software. Chi Square Test was performed to compare two proportions. The analysis was done for: age, gender, tooth with root caries in this study. The overall prevalence rate of root caries was found to be 57.9% among males and 42.1% among females. The Prevalence increased for both sexes almost consistently with age. The mean age group of occurance of root caries was found to be 51-65 years (39.1%). The intra oral distribution pattern of root caries revealed that the most frequently affected tooth type was found to be maxillary first and second molar (19.7%) in maxillary arch. The least frequently affected tooth was the mandibular incisor (1.1%). The results of the study shows that the occurrence of root caries increases with increase in age. Hence, older adults deserve attention concerning their actual role in the epidemiology of principal oral diseases and require future caries prevention programs.
How does Emotional Intelligence Impact Employee Performance? Validation of WEIP-S among Indian Professionals

Emotional Intelligence has been linked with many desirable performance outcomes, however the strength and nature of this impact has often been debated. Leading researchers advocate the use of specific, relevant and well established instruments in empirical research to study Emotional Intelligence at the workplace. To this end, the current work validates WEIP-S, a popular Emotional Intelligence measure which has been specifically tailored for use in organizational research for use among Indian respondents. Results of study 1 ( n = 253) and study 2 ( n=852 ) suggest that WEIP-S retains its original four factor structure and shows acceptable reliability when tested among working professionals from diverse economic sectors in India. Results of study 3 ( n=324) provide evidence for significant positive impact of Emotional Intelligence at the workplace, by linking WEIP-S scores to supervisor evaluations of performance. Additionally, results clarify the differential impact of the four dimensions of Emotional Intelligence on various aspects of employee performance.
Prevalence and Physical Environmental Conditions as Risk Factor for Pulmonary Tuberculosis in Indonesia 2015

OBJECTIVE: The number of tuberculosis (TB) cases in Indonesia is currently very high, so the analysis is needed to describe the environmental conditions at risk of TB disease. The aim of the study was to look at the prevalence of pulmonary TB in 2013-2014 in Indonesia based on the area of residence of the respondents and to see the relationship between the environmental conditions of the prevalence of TB in Indonesia. MATERIAL & METHODS: The Prevalence SPTB 2013-2014 was used cross-sectional design with national coverage. Sampling selection used multi-staged cluster sampling in the population aged 15 years and above. The analysis data used SPSS program; first analysis was used bivariate and continuing to multivariate analysis. RESULT: Tb prevalence rate with bacteriological confirmed was 759 [95% CI: 590, 961] per 100,000 population in aged 15 years and above. The bivariable analysis shown those participant who live at house with floor <8m2/person [95% CI:1,053,1,710] and those participant who lived in house with kitchen was not separated from the main living area in the house [95% CI: 1,034,1,669], that was significant related with TB. In the multivariable model, the density characterized by family members with a floor surface <8m2/person [95% CI: 1,017,1,671]is at risk of developing TB. CONCLUSION: This study shows that the effect of the physical environment of living in a crowded household can be a risk factor for TB transmission. The other factor might be influence of infection Tb in the community.