Miracle-dz/UniFAR-FTUs huggingface dataset:
Concordance between the Different Cardiovascular Risk Scores in People with Rheumatoid Arthritis and Psoriasis Arthritis

Aim To determine the cardiovascular risk and the concordance between the different scores in people with rheumatoid arthritis (RA) and psoriatic arthritis (PsA). Methods Observational descriptive study of prevalence. Performed in the Rheumatology Service and the Clinical Epidemiology and Biostatistics Unit of the University Hospital Complex of A Coruña (Spain). Patients diagnosed with RA or PsA, older than 18 years of age were included. Measurements: sociodemographic, anthropometric variables of the disease, comorbidity, cardiovascular risk, and therapeutic management. Results 151 subjects (75 RA and 76 PsA) were studied. The average age was 57.9 ± 12.2 years, 61.6% being women. The average of the Charlson index was 2.8 ± 1.5. 43% were overweight. 46.5% were classified as cardiovascular risk, and the average percentage was 33.3% by Framingham. The best agreement has been between Framingham and Dorica (k = 0.709; p < 0.001), classifying more than 80% of the cases in the same risk categories. Conclusions The most prevalent risk factors were overweight and obesity, followed by smoking and hypertension. The prevalence of patients with moderate/high cardiovascular risk varies according to the score used, the levels of concordance being the scores of Framingham and Dorica.
Short-term forecasts of COVID-19 spread across Indian states until 29 May 2020 under the worst-case scenario

The very first case of corona-virus illness was recorded on 30 January 2020, in India and the number of infected cases, including the death toll, continues to rise. In this paper, we present short-term forecasts of COVID-19 for 28 Indian states and five union territories using realtime data from 30 January to 20 May 2020. Applying Holt’s second-order exponential smoothing method and autoregressive integrated moving average (ARIMA) model, we generated 10-day ahead forecasts of the likely number of infected cases and deaths in India until 29 May 2020. Our results show that the number of cumulative cases in India will rise to169109 [PI 95% (14426, 19455)], concurrently the number of deaths may increase to 4863 [PI 95% (4221, 5551)] by 29 May 2020. Further, we have marked the states (e.g. Delhi, Uttar Pradesh, Rajasthan, Madhya Pradesh, Maharashtra, Gujarat, and Tamil Nadu) where outburst is expected by considering the cases above three standard deviations. Under the worst-case scenario, Maharashtra is likely to be the most affected state with around 62628 [PI 95% (52840, 73555)] cumulative cases by 29 May 2020. However, Kerala and Karnataka are likely to remain in the lesser affected region. The presented results mark the states where lockdown by 1 June 2020, can be loosened.
Dissipation of Pendimethalin and Fluchloralin in Soil and their Residue in Onion

Degradation of dinitroaniline herbicides viz., pendimethalin and fluchloralin is reported in a sandy loam soil in an onion field during rabi 1989–90 and 1990–91 at Gujarat Agricultural University Farm, Anand, Gujarat. The rate of dissipation of both the compounds showed first-order kinetics. Pendimethalin dissipated with half-life varying from 28,1 to 31.7 d when applied @ 0.75, 1.00, 1.25, 1.50 and 2.00 kg ha−1. Fluchloralin @ 1.0 kg ha−1 showed relatively faster rate of dissipation in a biphasic mode. During phase I (0–10 d), fluchloralin dissipated with half-life of 3.9 d whereas in second phase (10–110 d) the herbicide persisted with half-life valuueof0.5 5ays. Low levels of herbicide residue were detected in onion on the 60th day. The residue were absent at harvest.
Sodium-glucose cotransporter inhibitors: beyond glycaemic control

Abstract Diabetes increases the risk of adverse cardiovascular and renal events. Recently, sodium–glucose co-transporter 2 (SGLT2) inhibitors have been demonstrated to reduce cardiovascular complications and slow diabetic kidney disease progression in patients with type 2 diabetes. The glycaemic control exerted by these drugs is not greater than the one achieved with other classical glucose-lowering medications such as sulphonylureas. For that reason, plausible renoprotective mechanisms independent from glycaemic control have been proposed such as blood pressure control, body weight loss, intraglomerular pressure reduction and a decrease in urinary proximal tubular injury biomarkers. Interestingly, the hypothesis that SGLT2 inhibitors have a direct renoprotective effect has been addressed in diabetic and non-diabetic models. In this editorial, we update the different postulated mechanisms involved in the cardiorenal protection afforded by SGLT2 inhibition in chronic kidney disease.
Corrected Anion Gap and Hypernatremia as Predictors of Mortality in Pediatric Intensive Care Unit, Minia University Hospital: A Retrospective Study

Background Hypernatremia commonly occurs in ICUs, mostly developing soon after admission. It has been associated with prolonged ICU stay and has a mortality rate of 40–60%. The aim of our study is to estimate the values of serum anion gap (AG), corrected anion gap (CAG), and hypernatremia for an early prediction of mortality in pediatric intensive care units (PICUs). Materials and Methods This retrospective comparative study used data collected from the records of children admitted to the PICU at Minia University Hospital between June, 2017 and June, 2019. Results Patients were from 1 month to 18 years old. ROC curve analysis for the prediction of mortality showed the cutoff point of Na >154 (64.04% sensitivity and 79.75% specificity) and of cAG > 42.1 (57.37% sensitivity and 70.25% specificity). Conclusion Ventilation, respiratory failure, severe and moderate GCS, PH, CO2, anion gap, high cAG, hypernatremia, K, CL, CRP, PLT, and creatinine were significant predictors of mortality among children admitted to the PICU.
Transforming Schools Through Spiritual Leadership: A Field Experiment

Spiritual Leadership is a causal leadership model for organizational transformation (OT) designed to create an intrinsically motivated, learning organization. Spiritual leadership theory was developed within an intrinsic motivation model that incorporates vision, hope/faith, and altruistic love, theories of workplace spirituality, and spiritual survival through calling and membership. The purpose of spiritual leadership is to create vision and value congruence across the strategic, empowered team, and individual levels and, ultimately, to foster higher levels of organizational commitment and productivity. The purpose of this paper is to test and validate the general casual model for spiritual leadership through an experimental design that initially examined 229 employees from three elementary and one middle school. A one-year longitudinal field experiment was then conducted with two of the original schools by means of an OT visioning/ stakeholder analysis intervention performed in one school with another as a control. Results revealed strong support for the model and the intervention, especially in terms of a significant increase in organizational commitment. An action agenda for future research and teacher and school employee training and development leading to increased teacher retention, organizational commitment and productivity is then offered.
Defining the Role of Antibodies in Protection Against Cytomegalovirus Acquisition and Congenital Disease for Rational Vaccine Design

Defining the Role of Antibodies in Protection Against Cytomegalovirus Acquisition and Congenital Disease for Rational Vaccine Design by Cody S. Nelson Department of Molecular Genetics and Microbiology Duke University Date:_______________________ Approved: ___________________________ Sallie R. Permar, Supervisor ___________________________ Andrew Alspaugh ___________________________ Mary E. Klotman ___________________________ Stacy Horner ___________________________ Guido Ferrari ___________________________ Katharina Koelle An abstract of a dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Department of Molecular Genetics and Microbiology in the Graduate School of Duke University 2018 Copyright by Cody S. Nelson 2018
Health Benefits of Pea Protein Isolate: A Comparative Review

Pea protein isolate, derived from yellow split peas, is an increasingly prevalent additive and supplement in the food and beverage market, commonly found in alternative meats, meal replacements, cereal bars, alternative milks and additional food products. With pea protein isolate being relatively new to the market, there is not extensive research on its health benefits to coincide with its rising popularity. This review aims to cover the existing body of evidence to connect the known potential health benefits of pea protein isolate, as well as compare these health benefits to other protein alternatives that have been comprehensively researched such as soy and whey protein. The health benefits identified include its anabolic properties, high satiety effect, glycaemic-lowering effect, hypolipidemic effect and blood pressure lowering effect involving the renin-angiotensin-aldosterone system.
Marital Satisfaction: An Analysis of Long Distance Marriage Couples

This research aims to describe marital satisfaction of long distance marriage and and the difference marital satisfaction between husband and wife undergoing long-distance marriages(LDM). This research was a comparative research with a sample number of 45 couples who have LDM. Sample collection withdrawal technique using a purposive sampling technique. This research was measured using a Marital Satisfaction Inventory developed from ENRICH Marital Satisfaction Scale with a few adjustments. The research findings reveal that: (1) marital satisfaction of husband undergoing long-distance marriages is generally in medium category with a percentage of 70.25%, (2) marital satisfaction of wives undergoing LDM is generally in the high category with a percentage of 74.65%, and (3) there is no difference in marital satisfaction between husband and wife undergoing LDM with the value F of 4,940 with probability 0.029 smaller than 0.05.
Expression of CLDN6 in tissues of gastric cancer patients: Association with clinical pathology and prognosis

Expression of claudin-6 (CLDN6) in the tissues of gastric cancer patients and its association with clinical pathology and prognosis were investigated. A retrospective analysis was performed on 213 gastric cancer patients diagnosed and surgically treated in the Central Hospital of Zibo from January 2010 to January 2013. Cancer and normal adjacent tissues were obtained from the patients to detect the expression level of CLDN6 using reverse transcription-quantitative PCR (RT-qPCR). The association between the expression level of CLDN6 and the clinical and pathological features, as well as the prognosis of gastric cancer patients was analyzed. The expression level of CLDN6 was significantly lower in gastric cancer tissues than that in adjacent tissues (t=23.350, P<0.001). The expression level of CLDN6 was associated with age, lymph node metastasis, pathological staging, and distant metastasis (P<0.05). In this study, patients were separated into CLDN6 high-expression group (≥1.42) with 107 patients and CLDN6 low-expression group (<1.42) with 106 patients, with the median expression level of CLDN6 as the boundary. The 1-, 2- and 3-year survival rates of patients in the CLDN6 low-expression group were 80.19, 60.38 and 48.11%, respectively, and those in the CLDN6 high-expression group were 87.85, 73.83 and 66.36%, respectively. The survival rate was significantly better in the CLDN6 high-expression group than that in the CLDN6 low-expression group (P=0.009). In conclusion, the expression level of CLDN6 is low in the cancer tissues of gastric cancer patients, and associated with age, lymph node metastasis, pathological staging and distant metastasis. CLDN6 low expression has a certain negative impact on the prognosis of patients, and therefore, shows potential as an important indicator for the prognosis of gastric cancer patients.
Sleep disturbances in patients with Parkinson’s disease: It’s time to wake up!

Patients with Parkinson’s disease (PD) develop a range of non-motor symptoms (NMS). Sleep disturbance is one of the common NMS of PD and the onset of sleep disorders often precede the onset of motor symptoms of PD. Motor symptoms of PD often receive the main clinical focus and the sleep disturbances often go unnoticed in clinical practice. Given that the prevalence of PD is higher in the elderly population, primary care physicians, geriatricians, and gerontologists are usually the first point of contact for a majority of patients with PD. Because of this, it is important that they have a clear understanding about the diagnosis and management of the sleep disturbances in PD. This review provides an overview of the full spectrum of sleep disturbances in PD that includes insomnia, excessive daytime sleepiness, rapid eye movement sleep behavior disorder, restless leg syndrome, periodic limb movements, and obstructive sleep apnea. Although these sleep disorders may be primarily associated with PD, it is crucial to delineate the other treatable causes of sleep disturbances such as side effects of medications and physical symptoms not related to PD. This review highlights the major sleep disorders observed in patients with PD and succinctly discusses their management aspects. In addition, we have briefly described the effect of deep brain stimulation on the natural course of several sleep disorders in PD in this article.
Effects of Paclobutrazol and Pinching on Ornamental Pepper

S UMMARY . Pinching, manual removal of shoot apices, and/or plant growth regulators (PGRs) are used to create commercially preferred compact and well-branched ornamental plants. The inﬂuence of paclobutrazol (PB) with and without pinching on the growth and fruit characteristics of a tall ornamental pepper ( Capsicum annuum ) was assessed 2, 4, 6, and 8 weeks after the initial treatment. PB was sprayed on pinched or nonpinched whole plants at 5, 10, or 15 ppm a.i. Pinching and PB reduced the plant height between 25% and 50% and the canopy diameter up to 8% and 17%, respectively. Height/diameter ratio (H/D) ranged from 1.0 for 10 and 15 ppm PB applied to pinched plants to 2.3 for control plants. Paclobutrazol increased the SPAD chlorophyll value and total fruit number, delayed fruit set, and decreased fruit diameter and dry weight. The relationship between PB and plant height and diameter, SPAD chlorophyll value, dry weight, and fruit number was best explained by a third-order polynomial ( r 2 = 0.83–0.99). Paclobutrazol may substitute costly pinching treatment for height control and may offer an economic advantage for commercial greenhouse operators.
Timing and duration of moult in relation to weather conditions in four montane passerine species at the Gran Sasso, Central Italy

Summer primary and secondary moult were investigated in four species of passerines, Northern Wheatear Oenanthe oenanthe, Black Redstart Phoenicurus ochruros, Linnet Linaria cannabina and Water Pipit Anthus spinoletta, in a mountain environment in central Italy. For each species we determined mean starting date and duration of both primary and secondary moults, and whether factors such as spring precipitation or temperature affected the timing or the duration of each moult. Northern Wheatear, the only long-distance migrant among the study species, was the first to start and to complete its moult. Furthermore, this species was the only one to moult earlier in years with warmer springs and with less snow, as predicted. Black Redstarts, on the other hand, started to moult later in warmer years, possibly because a greater proportion of pairs produced a second brood. In each of the species with distinguishable sexes, moult began later in females than in males. In Linnets, females finished primary moult on average two days earlier than males, due to a shorter moult duration. Similarly, Black Redstart females finished their secondary moult exactly at the same time as males, despite a later start.
Increased circulating CD3+ T cells are associated with early relapse following autologous hematopoietic stem cell transplantation in patients with classical Hodgkin lymphoma

Abstract Non-malignant host immune cells are the main substrate in classical Hodgkin lymphoma (HL) microenvironment. Reconstitution of lymphocyte populations following the high-dose chemotherapy (HDC) with autologous hematopoietic stem cell transplantation (auto-HSCT) can support tumor growth in HL patients. We investigated recovery dynamics of circulating CD3+, CD4+, CD8+, CD16+/CD56+, CD19+, CD4+FOXP3+ lymphocytes following auto-HSCT in 79 HL patients and assessed relationship between these populations and the development of early relapse. Studied populations were not statistically significant between patients with high or standard/intermediate risk of relapse. CD3+ T cells at the time of engraftment were increased in patients with the early relapse of HL compared to non-relapsed patients (PU = 0.0028). Area under the curve was 0.76 (р = .0037). In logistic regression models, CD3+ T cell count was associated with early relapse/progression as a trend. These findings elucidate several interactions between early systemic T cell recovery and tumor progression following HDC with auto-HSCT.
Effect of high temperature and 1-MCP application or dynamic controlled atmosphere on energy savings during apple storage

Summary The aim of this work was to evaluate the energy saving benefits that new storage strategies such as ULO storage + 1-MCP at higher temperatures and DCA may have when compared to standard ULO. The experiment was carried out in three storage rooms (11 tons each) under ULO conditions (1.0 kPa O2 + 2.5 kPa CO2) at 1°C or ULO at 5°C plus 1-MCP or DCA controlled by chlorophyll fluorescence (~0.7 kPa O2 + 1.5 kPa CO2) at 1°C. The apple cultivars ‘Golden Delicious’, ‘Jonagold’ and ‘Pinova’ were stored for 7 months and the energy consumption for each of the three rooms calculated from the refrigeration compressors, ventilation fans, defrosting and CO2 scrubber machinery run-times. Energy use was reduced by 20% in DCA and 70% in ULO + 1-MCP at 5°C when compared to ULO at 1°C. Apples stored at 5°C showed a lower weight loss when compared to 1°C. Despite a higher storage temperature, 1-MCP treated ‘Jonagold’ at 5°C were firmer than fruit under either ULO or DCA at 1°C without 1-MCP. The firmness of ‘Golden Delicious’ and ‘Pinova’ did not differ between treatments. The incidence of fungal rots was slightly increased under ULO + 1-MCP at 5°C for ‘Jonagold’, but strongly reduced for ‘Pinova’. There were no treatment differences in rot incidence for ‘Golden Delicious’. Sensorial analyses conducted after storage plus 7 days shelf-life at 20°C rated the texture of ‘Jonagold’ higher for ULO at 5°C + 1-MCP than for ULO at 1°C without 1-MCP and accordingly, purchase preferences were higher for ‘Jonagold’ under ULO at 5°C + 1-MCP. ‘Pinova’ texture was rated best after DCA at 1°C. There were no differences in the texture preferences between ULO at 5°C + 1-MCP or ULO at 1°C without 1-MCP or any differences in taste preferences between the storage treatments for either ‘Jonagold’ or ‘Pinova’.
Genetic diversity of Colombian landraces of common bean as detected through the use of silver-stained and fluorescently labelled microsatellites

Colombia, situated at the northern end of the Andes mountains of South America and in proximity to Central America, is an important centre of diversity for common bean (Phaseolus vulgaris L.) that has a mix of cultivated germplasm from both major gene pools (Andean and Mesoamerican) for the species. Microsatellites are a useful marker system for analyzing genetic diversity of this crop and can be analyzed with manual (silver-stain) or automated (ABI) detection systems and using unlabelled or fluorescently labelled markers, respectively. The objectives of this research were to evaluate the genetic diversity of 92 Colombian landraces and gene pool controls with 36 fluorescent and 30 non-fluorescent microsatellite markers and to determine the extent of introgression between the Andean and Mesoamerican gene pools for this germplasm. A comparison of fluorescent versus non-fluorescent marker systems was performed with 14 loci, which were evaluated with both methods; the fluorescent markers were found to be more precise than the non-fluorescent markers in determining population structure. A combined analysis of 52 microsatellites using the 36 fluorescent markers and 16 non-overlapping, silver-stained markers produced an accurate population structure for the Andean gene pool that separated race Nueva Granada and race Peru genotypes and clearly identified introgression between these races and the gene pools. The results of this research are important for the application of microsatellite markers to diversity analysis in common bean and for the conservation of landraces in Colombia and neighbouring countries of Latin America, where similar germplasm exists and where gene pool or race mixtures also occur.
Stimulation in Acupoint St-36 and Cognitive Behavior Therapy Reduce Il-6 in Anxiety Disorders

Anxiety disorders in patients with chronic diseases can affect the healing process of the disease. Many cases of anxiety disorders in patients can lead to comorbidity of physical-mental illness. Acupoint stimulation therapy and Cognitive Behavior Therapy (CBT) is a combination of physical and psychological treatment methods to improve the recovery of mental physical comorbidity by improving the value of Interleukin 6 (IL-6). The purpose of the study was to see the effect of stimulation of acupoint ST-36 and CBT in reducing IL-6 levels in anxiety disorders. The research method used was an experiment with a control group and using pre and post test, the number of samples used was 20 people divided into two groups, control and treatment groups. The results showed that the stimulation of ST-36 and CBT points had a significant effect in reducing IL-6 levels in the blood compared to the control group. Based on psychological tests showed that the level of anxiety in the treatment group was better than the control group.