Miracle-dz/UniFAR-FTUs huggingface dataset:
Non-thermal production of minimal dark matter via right-handed neutrino decay

Minimal Dark Matter (MDM) stands as one of the simplest dark matter scenarios. In MDM models, annihilation and co-annihilation processes among the members of the MDM multiplet are usually very efficient, pushing the dark matter mass above 𝒪(10) TeV in order to reproduce the observed dark matter relic density. Motivated by this little drawback, in this paper we consider an extension of the MDM scenario by three right-handed neutrinos. Two specific choices for the MDM multiplet are studied: a fermionic SU(2)L quintuplet and a scalar SU(2)L septuplet. The lightest right-handed neutrino, with tiny Yukawa couplings, never reaches thermal equilibrium in the early universe and is produced by freeze-in. This creates a link between dark matter and neutrino physics: dark matter can be non-thermally produced by the decay of the lightest right-handed neutrino after freeze-out, allowing to lower significantly the dark matter mass. We discuss the phenomenology of the non-thermally produced MDM and, taking into account significant Sommerfeld corrections, we find that the dark matter mass must have some specific values in order not to be in conflict with the current bounds from gamma-ray observations.
DBI and the Galileon reunited

We derive the relativistic generalization of the Galileon, by studying the brane position modulus of a relativistic probe brane embedded in a five- dimensional bulk. In the appropriate Galilean contraction limit, we recover the complete Galileon generalization of the DGP decoupling theory and its conformal extension. All higher order interactions for the Galileon and its relativistic generalization naturally follow from the brane tension, induced curvature, and the Gibbons-Hawking-York boundary terms associated with all bulk Lovelock invariants. Our approach makes the coupling to gravity straightforward, in particular allowing a simple rederivation of the nonmini- mal couplings required by the Covariant Galileon. The connection with the Lovelock invariants makes the well-defined Cauchy problem manifest, and gives a natural unification of four dimensional effective field theories of the DBI type and the Galileon type.
Behavior Change App for Self-management of Gestational Diabetes: Design and Evaluation of Desirable Features

Background Gestational diabetes (GDM) has considerable and increasing health effects as it raises both the mother’s and the offspring’s risk for short- and long-term health problems. GDM can usually be treated with a healthier lifestyle, such as appropriate dietary modifications and sufficient physical activity. Although telemedicine interventions providing weekly or more frequent feedback from health care professionals have shown the potential to improve glycemic control among women with GDM, apps without extensive input from health care professionals are limited and have not been shown to be effective. Different features in personalization and support have been proposed to increase the efficacy of GDM apps, but the knowledge of how these features should be designed is lacking. Objective The aim of this study is to investigate how GDM apps should be designed, considering the desirable features based on the previous literature. Methods We designed an interactive GDM prototype app that provided example implementations of desirable features, such as providing automatic and personalized suggestions and social support through the app. Women with GDM explored the prototype and provided feedback in semistructured interviews. Results We identified that (1) self-tracking data in GDM apps should be extended with written feedback, (2) habits and goals should be highly customizable to be useful, (3) the app should have different functions to provide social support, and (4) health care professionals should be notified through the app if something unusual occurs. In addition, we found 2 additional themes. First, basic functionalities that are fast to learn by women with GDM who have recently received the diagnosis should be provided, but there should also be deeper features to maintain interest for women with GDM at a later stage of pregnancy. Second, as women with GDM may have feelings of guilt, the app should have a tolerance for and a supporting approach to unfavorable behavior. Conclusions The feedback on the GDM prototype app supported the need for desirable features and provided new insights into how these features should be incorporated into GDM apps. We expect that following the proposed designs and feedback will increase the efficacy of GDM self-management apps. Trial Registration ClinicalTrials.gov NCT03941652; https://clinicaltrials.gov/ct2/show/NCT03941652
Risk for Hemorrhage the First 2 Years After Gamma Knife Surgery for Arteriovenous Malformations: An Update

BACKGROUND: Knowledge about the natural course of brain arteriovenous malformations (AVMs) have increased during the past 20 years, as has the number of AVMs treated, especially larger ones. It is thus timely to again analyze the risk for hemorrhage after Gamma Knife Surgery (GKS). OBJECTIVE: To confirm or contradict conclusions drawn 20 years ago regarding factors that affect the risk for post-GKS hemorrhage. METHODS: The outcome after GKS was studied in 5037 AVM patients followed for up to 2 years. The relation between post-treatment hemorrhage rate and a number of patient, AVM, and treatment parameters was analyzed. The results were also compared with the results from our earlier study. RESULTS: The annual post-treatment hemorrhage rate was 2.4% the first 2 years after GKS. Large size, low treatment dose, and old age were independent risk factors for AVM hemorrhage. After having compensated for the factors above, peripheral AVM location and female sex, at least during their child bearing ages, were factors associated with a lower post-GKS hemorrhage rate. CONCLUSION: Large AVMs (>5 cm3) treated with low doses (≤16 Gy) had higher and small AVMs treated with high doses a lower risk for hemorrhage as compared with untreated AVMs. This was detectable within the first 6 months after GKS. No difference in hemorrhage rate could be detected for the other AVMs. Based on our findings, it is advisable to prescribe >16 Gy to larger AVMs, assuming that the risk for radiation-induced complications can be kept at an acceptable level.
Metric Renormalization in General Relativity

The averaging problem in general relativity concerns the difficulty of defining meaningful averages of tensor quantities and we consider various aspects of the problem. We first address cosmological backreaction which arises because the averaged Einstein tensor is not the same as the Einstein tensor of the averaged metric. It has been suggested that backreaction might account for the dark energy. We show numerically in the Buchert formalism that the corrections from (quasi)linear perturbations are only of the order of 10^-5 and act as a dark matter. We then focus on constructing averaged metrics and present a generally covariant averaging process which decomposes the metric into Vielbeins and parallel transports them with a relativistic Wegner-Wilson operator to a single point where they can then be averaged. The Vielbeins are chosen in a Lagrangian formalism. The functionality of the process is demonstrated in specific examples in two and three space dimensions. This involves the numerical solution of partial differential equations by the aid of the simulation toolkit Gascoigne.
Real-World Outcomes of Glaucoma Filtration Surgery Using Electronic Health Records: An Informatics Study

Précis: Utilizing an automated pipeline for data extraction from electronic health records provides real-world information on the success of various glaucoma procedures, with tube shunt implantation associated with increased failure rates compared with trabeculectomy. Background: We aimed to evaluate the long-term survival of glaucoma surgeries using an automated pipeline for extraction of outcomes from electronic health records. Methods: A retrospective observational study from a single academic center. Patients undergoing trabeculectomy, Ex-PRESS shunt, Baerveldt, and Ahmed tube shunt insertion from 2009 to 2018 were identified from electronic health record procedure codes. Patient characteristics were identified from structured and unstructured fields using a previously validated natural language processing pipeline. Results: Five hundred twelve patients underwent 711 glaucoma surgeries: 287 trabeculectomies, 47 Ex-PRESS shunts, 274 Baerveldt and 103 Ahmed tube implantations. The Median follow-up was 359 days. The mean baseline IOP was 24.4 mm Hg (SD 10.9), and 73.1% were on ≥3 medications. Compared with trabeculectomy, tube shunt surgery had a higher risk of failure (Baerveldt: Hazard Ratio (HR) 1.44, 95% CI 1.02 to 2.02; Ahmed: HR 2.01, 95% CI 1.28 to 3.17). Previous glaucoma surgery was associated with increased failure (≥2 previous surgeries: HR 2.74, 95% CI 1.62 to 4.64), as were fewer baseline medications (<3 medications: HR 2.96, 95% CI 2.12 to 4.13) and male sex (HR 1.40, 95% CI 1.03 to 1.90). At 1 year, tube shunt patients had a 2.53 mm Hg (P=0.002) higher IOP compared with trabeculectomy patients. Conclusions: Baerveldt and Ahmed tube shunt implantation was associated with increased failure compared with trabeculectomy. Fewer baseline medications, previous glaucoma surgeries, and male sex were also risk factors for failure. These results demonstrate the utility of applying an informatics pipeline to electronic health records to investigate key clinical questions using real-world evidence.
Energy Theory of Matter & Cosmology

A new theory ‘Energy Theory of Matter & Cosmology’, as an alternative theory, is proposed which could explain all the problems with different theories of physics, the main cause of which is space–time concept and resultantly the Big Bang Theory fails. Since it is established that the basic building substance of matter is ‘energy’ and it has to be under the influence of the Universal Creator this energy is converted into the matter. Energy is the name given to the basic substance of which the matter is made up of unlike the meaning as applies in the adopted main-stream physics. During the process of conversion of energy into particles, the particles attained high velocities and collisions of the particles started. These particles in the process of fusion emit radiation which finally have taken the form of Cosmic Background Radiation and under the influence of the conditions created by the Universal Creator and electromagnetic forces in different forms atoms, mainly hydrogen, started forming. Then these atoms under the influence of the gravitation force, which also being an electromagnetic force, started clustering and thereby stars and other astronomical bodies came into existence.
Global Crustal Dynamics of Magnetars in Relation to Their Bright X-Ray Outbursts

This paper considers the yielding response of a neutron star crust to smooth, unbalanced Maxwell stresses imposed at the core–crust boundary, and the coupling of the dynamic crust to the external magnetic field. Stress buildup and yielding in a magnetar crust are global phenomena: an elastic distortion radiating from one plastically deforming zone is shown to dramatically increase the creep rate in distant zones. Runaway creep to dynamical rates is shown to be possible, being enhanced by in situ heating and suppressed by thermal conduction and shearing of an embedded magnetic field. A global and time-dependent model of elastic, plastic, magnetic, and thermal evolution is developed. Fault-like structures develop naturally, and a range of outburst timescales is observed. Transient events with time profiles similar to giant magnetar flares (millisecond rise, ∼0.1 s duration, and decaying power-law tails) result from runaway creep that starts in localized sub-kilometer-sized patches and spreads across the crust. A one-dimensional model of stress relaxation in the vertically stratified crust shows that a modest increase in applied stress allows embedded magnetic shear to escape the star over ∼3–10 ms, dissipating greater energy if the exterior field is already sheared. Several such zones coupled to each other naturally yield a burst of duration ∼0.1 s, as is observed over a wide range of burst energies. The collective interaction of many plastic zones forces an overstability of global elastic modes of the crust, consistent with quasi-periodic oscillation (QPO) activity extending over ∼100 s. Giant flares probably involve sudden meltdown in localized zones, with high-frequency (≫100 Hz) QPOs corresponding to standing Alfvén waves within these zones.
Regulatory B cells protect against chronic hypoxia‐induced pulmonary hypertension by modulating the Tfh/Tfr immune balance

Hypoxia‐induced pulmonary hypertension (HPH) is a progressive and lethal disease characterized by the uncontrolled proliferation of pulmonary artery smooth muscle cells (PASMCs) and obstructive vascular remodelling. Previous research demonstrated that Breg cells were involved in the pathogenesis of pulmonary hypertension. This work aimed to evaluate the regulatory function of Breg cells in HPH. HPH mice model were established and induced by exposing to chronic hypoxia for 21 days. Mice with HPH were treated with anti‐CD22 or adoptive transferred of Breg cells. The coculture systems of Breg cells with CD4+ T cells and Breg cells with PASMCs in vitro were constructed. Lung pathology was evaluated by HE staining and immunofluorescence staining. The frequencies of Breg cells, Tfh cells and Tfr cells were analysed by flow cytometry. Serum IL‐21 and IL‐10 levels were determined by ELISA. Protein levels of Blimp‐1, Bcl‐6 and CTLA‐4 were determined by western blot and RT‐PCR. Proliferation rate of PASMCs was measured by EdU. Compared to the control group, mean PAP, RV/(LV + S) ratio, WA% and WT% were significantly increased in the model group. Anti‐CD22 exacerbated abnormal hemodynamics, pulmonary vascular remodelling and right ventricle hypertrophy in HPH, which ameliorated by adoptive transfer of Breg cells into HPH mice. The proportion of Breg cells on day 7 induced by chronic hypoxia was significantly higher than control group, which significantly decreased on day 14 and day 21. The percentage of Tfh cells was significantly increased, while percentage of Tfr cells was significantly decreased in HPH than those of control group. Anti‐CD22 treatment increased the percentage of Tfh cells and decreased the percentage of Tfr cells in HPH mice. However, Breg cells restrained the Tfh cells differentiation and expanded Tfr cells differentiation in vivo and in vitro. Additionally, Breg cells inhibited the proliferation of PASMCs under hypoxic condition in vitro. Collectively, these findings suggested that Breg cells may be a new therapeutic target for modulating the Tfh/Tfr immune balance in HPH.
Understanding the Signature of Controversial Wikipedia Articles through Motifs in Editor Revision Networks

Wikipedia serves as a good example of how editors collaborate to form and maintain an article. The relationship between editors, derived from their sequence of editing activity, results in a directed network structure called the revision network, that potentially holds valuable insights into editing activity. In this paper we create revision networks to assess differences between controversial and non-controversial articles, as labelled by Wikipedia. Originating from complex networks, we apply motif analysis, which determines the under or over-representation of induced sub-structures, in this case triads of editors. We analyse 21,631 Wikipedia articles in this way, and use principal component analysis to consider the relationship between their motif subgraph ratio profiles. Results show that a small number of induced triads play an important role in characterising relationships between editors, with controversial articles having a tendency to cluster. This provides useful insight into editing behaviour and interaction capturing counter-narratives, without recourse to semantic analysis. It also provides a potentially useful feature for future prediction of controversial Wikipedia articles.
LITHIUM DEPLETION IS A STRONG TEST OF CORE-ENVELOPE RECOUPLING

Rotational mixing is a prime candidate for explaining the gradual depletion of lithium from the photospheres of cool stars during the main sequence. However, previous mixing calculations have relied primarily on treatments of angular momentum transport in stellar interiors incompatible with solar and stellar data in the sense that they overestimate the internal differential rotation. Instead, recent studies suggest that stars are strongly differentially rotating at young ages but approach a solid body rotation during their lifetimes. We modify our rotating stellar evolution code to include an additional source of angular momentum transport, a necessary ingredient for explaining the open cluster rotation pattern, and examine the consequences for mixing. We confirm that core-envelope recoupling with a ∼20 Myr timescale is required to explain the evolution of the mean rotation pattern along the main sequence, and demonstrate that it also provides a more accurate description of the Li depletion pattern seen in open clusters. Recoupling produces a characteristic pattern of efficient mixing at early ages and little mixing at late ages, thus predicting a flattening of Li depletion at a few Gyr, in agreement with the observed late-time evolution. Using Li abundances we argue that the timescale for core-envelope recoupling during the main sequence decreases sharply with increasing mass. We discuss the implications of this finding for stellar physics, including the viability of gravity waves and magnetic fields as agents of angular momentum transport. We also raise the possibility of intrinsic differences in initial conditions in star clusters using M67 as an example.
THE PECULIAR PROPERTIES OF HORIZONTAL-BRANCH STARS IN ω CENTAURI

We measured temperatures, gravities, and masses for a large sample of blue horizontal-branch stars in ω Centauri, comparing the results with theoretical expectations for canonical and He-enriched stars, and with previous measurements in three other clusters. The measured gravities of ω Cen stars are systematically lower than canonical models, in agreement with expectations for He-enriched stars, and contrary to that observed in the comparison clusters. However, the derived masses are unrealistically too low as well. This cannot be explained by low gravities alone, nor by any of the other parameters entering the calculation. We find that the same stars are not brighter than their analogs in the other clusters, contrary to the expectations of the He-enrichment scenario. The interpretation of the results is thus not straightforward, but they reveal an intrinsic, physical difference between HB stars in ω Cen and in the three comparison clusters.
Secukinumab is effective and safe in the long‐term treatment of plaque psoriasis in a daily practice setting: Multicenter study in 384 Spanish patients

The aim of the study was to assess the long‐term effectiveness and safety of secukinumab in Spanish patients with moderate‐to‐severe psoriasis in a daily practice setting. Nationwide multicenter, observational, retrospective, non‐interventional, single‐cohort study including patients who initiated treatment with secukinumab in daily clinical practice conditions. Subjects were followed for a minimum of 3 months and a maximum of 24 months. Psoriasis Area Severity Index (PASI), Body Surface Area and Physician's Global Assessments were collected at baseline and months 3, 6, 12, 18 and 24 during treatment. Adverse events and reasons for secukinumab withdrawal were collected and classified for analyses. A total of 384 patients were enrolled in the study. Median PASI declined rapidly from 14.3 at baseline to 2.7 at month 3, 2.1 at month 12, and remained low (2.8) at month 24. Within the group of patients with PASI ≥10 at baseline (n = 278), 58.3%, 60.4% and 56.5% achieved a PASI90 response at months 3, 12 and 24, respectively. As for absolute PASI, 86.5%, 69.5%, 42.7% and 37% achieved PASI <5, < 3, < 1 and 0, respectively, at month 3. Secukinumab was more effective in biologic‐naïve patients and in those with lower Body Mass Index. Secukinumab presented a good long‐term safety profile. Secukinumab was effective and safe in a routine clinical setting, in a large cohort of patients with moderate‐to‐severe plaque psoriasis, in the short‐, medium‐ and long‐term (up to 24 months).
Line-of-sight geometrical and instrumental resolution effects on intensity perturbations by sausage modes

Context. Diagnostics of magnetohydrodynamic (MHD) waves in the solar atmosphere is a topic that often encounters interpretation problems, partly because of the high complexity of the solar atmospheric medium. Forward modelling can significantly guide interpretation, bridging the gap between numerical simulations and observations, and increasing the reliability of mode identification for applying MHD seismology. Aims. We determine the characteristics of the fast MHD sausage mode in the corona on the modulation of observable quantities, such as line intensity and spectral line broadening. Effects of the line-of-sight angle and of spatial, temporal, and spectral resolutions are considered. Methods. We take a cylindrical tube that simulates a loop in a low-β coronal environment with an optically thin background and let it oscillate with the fast sausage mode. A parametric study is performed. Results. Longitudinal structuring of the intensity modulation is obtained and set by the nodal structure of the radial velocity. The modulation is strongly dependent on the contribution function of the spectral line. Under the assumption of equilibrium ionisation, the intensity variation can be very low (4% for Fe ix 171) or significant (35% for Fe xii 193). Most of this variation disappears when considering the radiative relaxation times of the ions, due to the fast timescales of the sausage mode in the corona. Regardless of the ionisation state of the plasma, the variation in spectral line broadening can be significant, even for low intensity modulation. The nature of this broadening is not thermal but is mostly turbulent. This places spectrometers in clear advantage over imaging instruments for the detection of the sausage mode. The modulation of all quantities can considerably decrease with the line-of-sight angle with respect to the perpendicular to the tube axis. The spatial and temporal resolution are the main factors affecting modulation, erasing longitudinal structuring when these are on the order of the mode’s wavelength or the mode’s period, placing high constraints on instrumentation. Significant variability in all quantities can still be obtained when viewing at an angle of up to 30 ◦ , with pixel size resolutions up to one-third of the mode’s wavelength, or temporal resolution of one fifth of the mode’s period. Modulation is only weakly dependent on spectral resolution due to the mode’s inherent symmetry.
DISKOSEISMOLOGY AND QPOs CONFRONT BLACK HOLE SPIN

We compare the determinations of the angular momentum of stellar mass black holes via the continuum and line methods with those from diskoseismology. The assumption that is being tested is that one of the quasi-periodic oscillations (QPOs) in each binary X-ray source is produced by the fundamental g-mode. This should be the most robust and visible normal mode of oscillation of the accretion disk, and therefore its absence should rule out diskoseismology as the origin of QPOs. The comparisons are consistent with the second highest frequency QPO being produced by this g-mode, but are not consistent with models in which one QPO frequency is that of the innermost stable circular orbit.