Miracle-dz/UniFAR-FTUs huggingface dataset:
Juran on leadership for quality : an executive handbook

The subject of management for quality has undergone rapid and drastic change as a result of competition in the marketplace and the vulnerability of industrialized societies that depend heavily on the quality of goods and services. In this companion volume to his acclaimed 'Juran on Planning for Quality,' J.M. Juran provides top-level managers with the specific, field-tested methods they need to successfully lead their companies on the quest for superior quality. Managers have long recognized that the most sound response to a competitive challenge is to become more competitive. Today, informed managers also realize that quality improvement is the best source of competitive advantage. They know that return on investment in quality improvement projects is among the highest available. Yet, the means by which management can supply the leadership necessary to attain quality goals remains elusive. J.M. Juran has drawn on the experiences of thousands of chief executives in companies around the world to create a clear plan of action applicable to any industry, whether service or manufacturing. The famous "Juran Trilogy," clearly presented step-by-step, shows how to apply the familiar business concepts of planning, control, and improvement to quality leadership. For each concept, Dr. Juran provides a succinct and proven series of actions. He gives criteria for selecting project-by-project improvements and mobilizing a team to carry them out. He also describes a realistic timetable of implementation and directs the formation of an ongoing quality council whose job is to launch, coordinate, and "institutionalize" annual quality improvement. The membership of this council, as Dr. Juran insists, must come from the ranks of senior managersthe stakes are too high for upper managers not to personally become the leaders and members of this vital council. Using real-world case examples of highly profitable quality improvements in such companies as Bethlehem Steel and Florida Power
Stress release process along a crustal fault analogous to the plate boundary: a case study of the 2017 M5.2 Akita-Daisen earthquake, NE Japan

Stress accumulation and release in the crust remains poorly understood compared to that at the plate boundaries. Spatiotemporal variations in foreshock and aftershock activities can provide key constraints on time-dependent stress and deformation processes in the crust. The 2017 M5.2 Akita-Daisen intraplate earthquake in NE Japan was preceded by intense foreshock activity and triggered a strong sequence of aftershocks. We examine the spatiotemporal distributions of foreshocks and aftershocks and determine the coseismic slip distribution of the mainshock. Our results indicate that seismicity both before and after the mainshock was concentrated on a planar structure with N-S strike that dips steeply eastward. We observe a migration of foreshocks towards the mainshock rupture area, suggesting that foreshocks were triggered by aseismic phenomena preceding the mainshock. The mainshock rupture propagated toward the north, showing less slip beneath foreshock regions. The stress drop of the mainshock was 1.4 MPa and the radiation efficiency was 0.72. Aftershocks were intensely triggered near the edge of large coseismic slip regions where shear stress increased. The aftershock region expanded along the fault strike, which is attributed to the post-seismic aseismic slip of the mainshock. The postseismic slip possibly triggered repeating earthquakes with M ̃3. We find that the foreshocks, mainshock, aftershocks, and post-seismic slip released stress at different segments along the fault, which may reflect differences in frictional properties. Obtained results were similar to those observed for interplate earthquakes, which supports the hypothesis that the deformation processes along plate boundaries and crustal faults are fundamentally the same.
Investigation of self-phase modulation limitation on 10-Gbit/s transmission over different types of fiber

Summary form only given. For multichannel systems over various types of fiber infrastructures, one option for increasing the throughput is the increase of the individual channel rate, which imposes an increase in the required signal-to-noise ratio (SNR) at the receiver, hence in the output power of in-line amplifiers. The other option is to increase the number of channels, with the total output power of the amplifiers set for an adequate SNR for all channels. However, should several channels not be transmitted, the power per channel rapidly increases, in absence of gain control, as in present commercially available systems. In both scenarios, self-phase modulation (SPM) can become the limiting factor. The experimental setup for the investigation of SPM-induced limitation at 10 Gbit/s is given. Various types of dispersive fibre are experimented with.
Preliminary Study of Habitat-Related Bat Fauna of Mastouta-Bishshouk Region (Northwest Tunisia)

Abstract In order to define appropriate conservation measures in northern Tunisia we surveyed the bat fauna of Mastouta-Bishshouk region in both roosting sites and foraging areas. A total of 11 species was recorded. We found only three occupied roosts including a maternity colony of Rhinolophus ferrumequinum, Miniopterus schreibersii and Myotis cappacinii in a train abandoned tunnel. A tunnel of water channel hosted Rhinolophus mehelyi, M. schreibersii and M. punicus. Echolocation calls were recorded at a bridge over Beja Wadi, at an artificial basin, and in crop fields. Bat activity was the highest at the bridge in late March, and null in the harvested crop fields in late August. Pipistrellus kuhlii was the most active bat species in the three sites, Pipistrellus pipistrellus was the second most active species, followed by Eptesicus isabellinus. Plecotus gaisleri and Myotis punicus were detected only once at the bridge and the basin respectively. This bat assemblage is representative of the bat fauna of northern Tunisia. Roost and foraging area surveys strongly benefit acoustic recording, even in winter when some bats remain active. The rare local underground roosts should be protected from human disturbance and the water quality of Majerda Wadi should be improved.
Polarized mapping Raman spectroscopy: identification of particle orientation in biominerals

Abstract The identification of the texture of biominerals and the particle orientation in the bivalve shells of Anodonta cygnea was performed using polarized Raman spectroscopy mapping measurements. A single crystal of aragonite served as a reference to disclose orientational information on the mesoscopic scale. The relative intensities of different Raman modes combined with the determination of depolarization ratio of the Ag Raman mode at 1087 cm−1 of an aragonite single crystal was used to indicate the angular variation of aragonite crystallites in biominerals. The imaging technique shows that the a- and b-axis of aragonite crystallites in both, nacreous and prismatic layers do not only have one orientation but they are organized in a domain-type arrangement. The angular divergence in the prismatic layer of the shells is larger and hence, the crystallites in the nacreous layer have a higher degree of co-orientation. Results provide relevant textural information about aragonitic shells and indicate a sensitive technique to evaluate the crystal orientation in biominerals.
An investigation into the use of CCTV footage to improve likeness in facial composites

Facial composites are an important investigative tool and have been used in numerous high-profile cases (e.g. Yorkshire Ripper). Despite this, a great deal of research has indicated that composites often portray very poor facial resemblance to the suspect/target. While some of the difficulties with the older composite systems (e.g. Photofit and Identikit) were due to system design (see e.g. Ellis, Shepherd & Davies, 1975; Davies, Ellis & Shepherd, 1978; Laughery & Fowler (1980), the hit rate for composites constructed with more modern systems (e.g. E-FIT and PROfit) can still be very low (e.g. Frowd et al. 2005). While research has indicated that composite likeness can be improved at test by combining composites from multiple witnesses (e.g. Bennet, Brace, Pike, & Kemp 1999; Bruce, Ness, Hancock, Newman, & Rarity, 2002; Ness, 2003) research on improving composites during construction has produced mixed results.
TINDAK PIDANA CYBER TERRORISM DALAM TRANSAKSI ELEKTRONIK

Transaksi elektronik berkembang sangat cepat seiring dengan kebutuhan manusia modern sekarang yang membutuhkan kecepatan dan ketepatan dalam memperoleh informasi sehingga mendorong manusia untuk menciptakan cara agar dapat mempermudahnya dalam mendapatkan informasi tersebut atau juga biasa disebut internet . Kejahatan komputer perlu di waspadai juga tindakan terorisme yang dilakukan melalui cyberspace ini. Hal ini memungkinkan terjadi di dunia maya hanya saja caranya berbeda dengan tindakan terorisme konvensional yang ada di dunia nyata tetapi efeknya dapat dirasakan juga pada dunia nyata. Penelitian ini merupakan suatu penelitian yang bersifat yuridis-normatif. Untuk menghimpun bahan yang diperlukan, maka penulis telah menggunakan metode penelitian kepustakaan, yaitu dengan cara mempelajari buku-buku hukum, artikel-artikel yang membahas masalah hukum, himpunan peraturan perundang-undangan yang berlaku di Indonesia, serta berbagai sumber tertulis lainnya. Hasil penelitian menunjukkan tentang bagaimana merumuskan delik terhadap tindak pidana cyber terrorism dalam transaksi elektronik sesuai dengan hukum positif yang berlaku di Indonesia serta bagaimana penerapan hukum positif Indonesia terhadap tindak pidana cyber terrorism dalam transaksi elektronik. Pertama, delik pada Undang- Undang No. 15 Tahun 2003 tentang Pemberantasan Tindak Pidana Terorisme dan Undang-Undang Nomor 11 Tahun 2008 tentang ITE untuk menjerat pelaku tindak pidana cyber terrorism yang mana cyber terrorism dapat dijerat menggunakan Undang-Undang Nomor 23 tahun 2003 tentang Pemberantasan Tindak Pidana Terorisme dan Undang-Undang Nomor 11 Tahun 2008 tentang ITE. Kedua, Peraturan perundang-undangan yang masih berlaku dan efektif untuk di hubungkan agar dapat menjerat pelaku tindak pidana cyber terrorism yaitu Undang-Undang Republik Indonesia Nomor 15 Tahun 2003 tentang Tindak Pidana Terorisme dan Undang-Undang Republik Indonesia Nomor 11 Tahun 2008 tentang Informasi dan Transaksi Elektronik. Kedua, Hukum positif di Indonesia cukup efektif digunakan untuk menjerat pelaku tindak pidana cyber terrorism dengan menggabungkan dua peraturan perundang-undangan yaitu Undang-Undang Nomor 15 tahun 2003 tentang Tindak Pidana Terorisme dengan Undang-Undang Nomor 11 Tahun 2008 tentang Informasi dan Transaksi Elektronik. Dari hasil penelitian dapat ditarik kesimpulan bahwa penggunaan Undang-Undang No. 15 Tahun 2003 tentang Pemberantasan Tindak Pidana Terorisme dan Undang-Undang Nomor 11 Tahun 2008 tentang ITE untuk menjerat pelaku tindak pidana cyber terrorism. Dengan menggabungkan dua peraturan perundang-undangan yaitu Undang-Undang Nomor 15 tahun 2003 tentang Tindak Pidana Terorisme dengan Undang-Undang Nomor 11 Tahun 2008 tentang Informasi dan Transaksi Elektronik Hukum positif di Indonesia cukup efektif digunakan untuk menjerat pelaku tindak pidana cyber terrorism.
Minimally Invasive Micro Sclerostomy (MIMS) Procedure: A Novel Glaucoma Filtration Procedure

Précis: Intermediate-term results suggest that ab interno Minimally Invasive Micro Sclerostomy (MIMS) stent-less subconjunctival filtration procedure is a promising treatment option for patients with open-angle glaucoma (OAG). Purpose: MIMS is a novel ab interno, stent-less, subconjunctival filtration procedure. This study set to investigate the safety, performance, and efficacy of MIMS in OAG patients. Methods: Prospective, open-label, single arm clinical trial with intrasubject comparisons. Study participants were adults with OAG who were candidates for a filtration procedure. Patients were operated by a single surgeon (A.A.) in Chennai, India. Following mitomycin-C pretreatment, ab interno MIMS procedure was performed alone or combined with phacoemulsification surgery. Procedure-related complications and adverse events were assessed. Primary outcomes: patients (%) achieving an intraocular pressure (IOP) ≥5 mm Hg and ≤18 mm Hg, and an IOP reduction of >20% as compared with baseline, with or without hypotensive medications, with no need for recurrent surgery. Results: Twenty-one phacoemulsification-MIMS and 10 standalone MIMS procedures were performed. Mean age was 63.94±6.33 years. Mean duration of MIMS was 1:58±0:25 (min:s). Scleral tunnels were achieved in all cases. No device malfunctions, intraoperative complications, or serious adverse events were reported. Five (16.12%) patients presented with iris clogging 1 to 24 weeks following procedure. Two were treated with laser and 3 required trabeculectomy. Mean IOP change from baseline at 24 weeks was 47.4% (31.2 to 16.4 mm Hg, P<0.0001, n=23). The mean difference was −14.8 mm Hg (95% confidence interval: −17.6, −11.9) with no statistically significant differences between groups. Qualified success was achieved in 21 (84%), 17 (74%), and 13 (93%) after 12, 24, and 52 weeks, respectively. Complete success was achieved in 17 (68%), 13 (57%), and 8 (57%) after 12, 24, and 52 weeks, respectively. Conclusions: The interim results suggest that MIMS procedure may be a simple and effective surgical option for early OAG patients requiring target IOP in high teens although iris clogging of incision site is the major concern with this procedure.
Angiotensin receptor-neprilysin inhibition by sacubitril/valsartan attenuates doxorubicin-induced cardiotoxicity in a pretreatment mice model by interfering with oxidative stress, inflammation, and Caspase 3 apoptotic pathway.

OBJECTIVE Doxorubicin (DOX) is a well-known cardiotoxic agent, whereas sacubitril/valsartan (Sac/Val) is an effective treatment option in heart failure. In this study, we aimed to evaluate the effect of Sac/Val on DOX-induced cardiotoxicity in pretreatment mice model. METHODS A total of 24 mice were equally classified into 4 groups; control group, DOX (20 mg/kg; fifth day), Sac/Val (80 mg/kg), and Sac/Val+DOX (Sac/Val was given from day one of the study before doxorubicin administration). Electrocardiography parameters, including durations of QRS, ST, QT, PP segment, and QT/PQ index were measured. Total antioxidant status (TAS), total oxidant status (TOS), tumor necrosis factor-α (TNF-α), interleukin 1β (IL-1β), IL-6, NT-proBNP concentrations, and Caspase 3 activity were evaluated. RESULTS At the end of the 9-day study duration, QRS, ST, QT intervals, QT/PQ index and TAS, TOS, TNF-α, IL-1β, IL-6 levels were significantly higher in the DOX group than in the control group (p<0.001). Moreover, there were significant differences only in the PP interval when comparing the Sac/Val+DOX and control groups (p<0.001). QRS, ST, QT intervals, and QT/PQ index, TAS, TOS, TNF-α, IL-1β, IL-6 levels were significantly lower in the Sac/Val+ DOX group compared with the DOX group (p<0.001). Furthermore, NT-proBNP levels were lower in the Sac/Val+DOX group compared with the DOX group along with less Caspase 3 apoptosis. CONCLUSION Sac/Val seems to be cardioprotective against DOX-induced cardiotoxicity in pretreatment mice model. These findings can be attributed to the antiarrhythmic, anti-inflammatory, antioxidant, and antiapoptotic effects of Sac/Val as shown in this study.
Experimental Investigation of Sand Box Biodiesel Performance in an Internal Combustion Engine

A four stroke single cylinder air cooled direct internal combustion engine was used to investigate engine performance; CO, NOx, smoke opacity, flue gas temperature and brake specific fuel consumption with the Sand box Biodiesel blends Biodiesel. Biodiesel was produced from Sand boxoil by two steps (acidic and basic). The experiment was carried out in triplicate to determine the production conditions with optimum yield. The produced Biodiesel had fuel properties which satisfied both ASTME D6751 and EN 1424 standards. The fatty acid profile of the Biodiesel revealed the dominant fatty acids were linoleic (64.50%), oleic (17.54%) andpalmitic (12.70%). Exhaust emissions from an internal combustion (I.C.) engine revealed that the CO and NOx emissions reduction were 60% and 58% at B20 respectively. Meanwhile, the HC emission reduction was found to be 60% at B20, Smoke opacity emission reduction was found to 64% at B20, BSFC was found to be 42% emission reduction at B20. However, the flue gas temperature and BTE increased by 12% and 45%, respectively. Hence, Sand box Biodiesel is an environmentally friendly engine fuel. Keywords:Sand box, Biodiesel, Fatty acids, Intenal combustion engine, Exhaust emissions.
AXL/MERTK inhibitor ONO-7475 potently synergizes with venetoclax and overcomes venetoclax resistance to kill F LT 3-ITD acute myeloid leukemia

FMS-like Tyrosine Kinase 3 (FLT3) mutation is associated with poor survival in acute myeloid leukemia (AML). The specific Anexelekto/MER Tyrosine Kinase (AXL) inhibitor, ONO-7475, kills FLT3-mutant AML cells with targets including Extracellular-signal Regulated Kinase (ERK) and Myeloid Cell Leukemia 1 (MCL1). ERK and MCL1 are known resistance factors for Venetoclax (ABT-199), a popular drug for AML therapy, prompting the investigation of the efficacy of ONO-7475 in combination with ABT-199 in vitro and in vivo. ONO-7475 synergizes with ABT-199 to potently kill FLT3-mutant acute myeloid leukemia cell lines and primary cells. ONO-7475 is effective against ABT-199-resistant cells including cells that overexpress MCL1. Proteomic analyses revealed that ABT-199-resistant cells expressed elevated levels of pro-growth and anti-apoptotic proteins compared to parental cells, and that ONO-7475 reduced the expression of these proteins in both the parental and ABT-199-resistant cells. ONO-7475 treatment significantly extended survival as a single in vivo agent using acute myeloid leukemia cell lines and PDX models. Compared to ONO-7474 monotherapy, the combination of ONO-7475/ABT-199 was even more potent in reducing leukemic burden and prolonging the survival of mice in both model systems. These results suggest that the ONO-7475/ABT-199 combination may be effective for AML therapy.
Mechanical Thrombectomy Outcomes in COVID-19 Patients With Acute Ischemic Stroke

Background: Coronavirus disease 2019 (COVID-19) has been shown to associate with increased risk of thromboembolic events. Mechanical thrombectomy (MT) has long been used to effectively manage those with large-vessel occlusive (LVO) stroke and has similarly been implemented in the management of stroke in COVID-19 patients. Review Summary: The COVID-19 pandemic took the health care sector by a storm. Thus, less is known about MT outcomes in this population and evidence suggesting poor outcomes postthrombectomy for COVID-19 patients is accumulating. We provide a narrative on some of the published studies on the outcomes of MT in COVID-19 patients with LVO between March 2020 and February 2021. A description of patient characteristics, risk factors, COVID-19 infection severity, stroke features and thrombectomy success in this population is also presented as data from several studies show that LVO in COVID-19 patients may have some distinguishing characteristics that make management more challenging. Conclusions: The effect of COVID-19 on the long-term prognosis of stroke patients after thrombectomy is yet to be determined. The accumulating evidence from current studies indicates a negative impact of COVID-19 on outcomes in acute ischemic stroke patients who receive MT, irrespective of timely, successful angiographic recanalization. This review may help alert clinicians of some of the COVID-19-specific postthrombectomy challenges.
Lived experiences of patients with placenta accreta spectrum in Utah: a qualitative study of semi-structured interviews

Objective To describe the lived experience of patients undergoing diagnosis and treatment of placenta accreta spectrum (PAS). Design Qualitative study of semi-structured interviews. A content analysis was used to analyse interview data using a consistent set of codes to designate data segments that contain similar material. Codes were analysed and grouped based on thematic similarities. Thematic results were systematically reviewed, verified and audited to address trustworthiness and rigour of the data and analysis. Setting A single PAS programme in Utah, USA, from 2017 to 2020. Participants Patients with PAS during the study period were eligible. Those experiencing fetal demise or termination were excluded. Of 25 patients contacted at random, 17 agreed to participate in interviews. Those included were predominantly non-Hispanic white, highly parous, with average age of 34.7 years. Results The lived experiences of patients with PAS emerged across the time continuum from diagnosis, pregnancy, birth, to postpartum care and recovery. Themes common across the care continuum were: the emotional burden of diagnosis and management; fear and uncertainty related to health outcomes; and lack of autonomy and medical helplessness related to medical decision-making. Many patients experienced birth-related trauma, mourned the loss of future fertility and were dissatisfied with the lack of options for treatment for this serious pregnancy complication. Conclusions Patients undergoing diagnosis and treatment for PAS often experienced care that conflicted with their goals for pregnancy and birth. Clinical care for PAS would benefit from interventions aiming to engage patients and providers in shared decision-making and systems designed to address the social, psychological and emotional needs of patients with PAS.
Can In Vitro–In Vivo Extrapolation Be Successful? Recognizing the Incorrect Clearance Assumptions

For a number of years, our laboratory has been investigating the underlying reasons for the published poor in vitro–in vivo extrapolation (IVIVE) predictability of human clearance both from a theoretical and from an experimental perspective. Here, we critically examine clearance concepts and commonly employed IVIVE approaches, concluding that there is no theoretical reason that IVIVE should work, just as it does not. Our analysis, however, has identified 10 misconceptions and/or poorly understood aspects of clearance that are listed in the Conclusion section of this manuscript. Chief among these are that all published human drug clearance values are arterial clearances—clearance calculated as organ blood flow multiplied by the extraction ratio is the arterial clearance of the organ of elimination (and not the published drug clearance value)—and that the well‐stirred model equation taught in all pharmacokinetic courses that relates organ blood flow, fraction unbound in blood, and intrinsic clearance has no validity. We further list 10 conclusions relating to the IVIVE process. The primary IVIVE‐related conclusions are that the intrinsic clearance value determined from an in vitro incubation is an arterial intrinsic clearance, there is no theoretical basis upon which an arterial intrinsic clearance can be related to a whole‐body arterial clearance to accomplish IVIVE, there are no published data demonstrating that in vitro intrinsic metabolic clearance can predict in vivo organ clearance as IVIVE assumes, and the scientific basis for the hypothesized albumin‐mediated hepatic uptake phenomenon is invalid. We further propose three IVIVE process recommendations.