Miracle-dz/UniFAR-FTUs huggingface dataset:
Extensive Primary Orbital Malignant Melanoma Associated with Nevus of Ota

Primary orbital malignant melanoma is an extremely rare condition to present alone without previous extension of choroidal or conjunctival involvement. We reported the first case of malignant orbital melanoma without ocular involvement in a patient with nevus of Ota. A 52-year-old man presented with left proptosis and extensive bluish black pigmentation on left side of the face classified as Tanino type II of nevus of Ota and left ocular melanocytosis from birth. CT scan imaging showed extensive orbital mass occupying most of the orbital space. Transconjunctival biopsy was performed and a very pigmented mass was discovered, confirming the histopathology result of malignant melanoma. The patient was given up to five cycles of chemotherapy regimen. On serial orbital CT Scan, 33% of the tumor mass has disappeared after completing three cycles.
Fire Dynamics in Boreal Forests Over the 20th Century: A Data-Model Comparison

Fire regimes across the world are expected to be altered by continuing variations in socio-economic conditions and climate. Current global fire-vegetation models are able to represent the present-day fire activity, but it is unclear how well they can simulate past or future scenarios. Here we use sedimentary charcoal-based biomass burning reconstructions to evaluate fire probability and total carbon flux emitted to the atmosphere per year simulated by the dynamic global vegetation model LPJ-GUESS with its incorporated fire model SIMFIRE-BLAZE across the boreal region during the last century. The analyses were run for the whole time period (1900–2000 CE), as well as for the intervals 1900–1950 CE and 1950–2000 CE. The data–model comparison for the 20th century reveals a general disagreement in trends between charcoal reconstructions (with decreasing or stable trends) and simulations (showing an overall increase) at both global (boreal forests) and continental scales (North America and Fennoscandia), as well as for most of the regional sub-areas (Canada, Norway and Sweden). The only exceptions are Alaska and Finland/Russia Karelia, where all the variables increase. Negative correlations between observations and model outputs are also recorded for the two different sub-periods, except for Alaska and North America during the time interval 1900–1950 CE, and Norway and Finland/Russia Karelia between 1950 and 2000 CE. Despite several uncertainties in charcoal records, main differences between modeled and observed fire activity are probably due to limitations in the representation of the human impact on fire regime (especially connected to forest management and landscape fragmentation) in the model simulations.
The Relationship between Income Inequalities and Economic Growth: New Evidence

Purpose: The study aims to analyze the relationship between the pace of economic development expressed by the GDP index and the level of income inequalities measured by the Gini coefficient. Design/Methodology/Approach: The research hypothesis assumes that the level of income inequalities influences GDP growth. I hypothesize that this relationship is negative – a lower level of income inequalities favor the economic growth. I use the GDP per capita (per adult) year-to-year index to measure the pace of economic development. GDP index is a dependent variable in all estimated models. The explanatory variables are, GINI index, net national saving, public goods spending, country's dummy variables, year dummy variables. Findings: Using data from 43 countries covering the years 1990-2017, I prove that (1) higher income inequality is related to higher economic growth (but only on the level of the sample); (2) a level of savings affects the economic growth positively; (3) a higher level of spending on public goods affects GDP positively (on the level of the whole sample and in the group of more improve rished countries). Practical Implications The analysis confirms the positive relationship between income inequalities and the pace of economic development, but only at the whole sample level. Higher public spending positively affects economic growth. Savings accumulated by the citizens significantly affect economic growth, as a higher level of savings creates greater investment opportunities. Originality/Value: Inequalities are an inherent part of society and the economy. It is often presumed that if the level of income inequality is too high, it negatively affects the economy by lowering the development pace. Although the previous findings are somewhat mixed, I pose the research hypothesis assuming a low level of income inequality is linked to higher GDP growth.
Novel Confinement Possibility for Laser Shock: Use of Flexible Polymer Confinement at 1064 nm Wavelength

Through the years, laser shock peening became a treatment of choice in the aerospace industry to prolong the life of certain critical pieces. Water flow is commonly used as a confinement to improve the process capability but some applications cannot allow for water presence in the area of interest. In a previous article, an alternative to the water confinement was presented, a flexible polymer confinement was used and demonstrated the production of pressures equivalent to the water configuration treatment. However, laser parameters have been restricted to a wavelength in the visible range at 532 nm. In this paper, the study is extended to 1064 nm which is commonly used in LSP applications and with two different pulse durations. A 1064 nm near infra-red laser is used to do pressure characterization of shots with polymer confinement through Velocity Interferometer System for Any Reflector (VISAR) measurements coupled with Finite Element Modelling on Abaqus software. The results show that the pressures produced by the confinement is slightly lower with the 1064 nm wavelength, similar to what is observed with the classic water confined regime when switching from 532 nm to a near infra-red wavelength. Nevertheless, the high level of pressure produced by laser shock under the polymer confinement configuration allows for the treatment of common types of metal alloys used in the aerospace industry. Although the use of such a confinement has yet to be applicable to peening setups, it has already uses in some single shot configurations such as LasAT where it allows the avoidance of the water flow optimization.
Problematic behaviours and flow experiences during screen-based activities as opposite outcomes of the dual process of passion and basic needs

ABSTRACT Drawing on the self-determination theory (SDT) framework and the dualistic model of passion, the current study sought to test a model in which psychological basic needs differently predicted harmonious and obsessive passion, which in turn lead to problematic behaviours and flow experience across two different screen-based activities (gaming and social network use) through two separate studies. Across all studies, the results showed that higher levels of needs frustration in general life are likely to promote higher levels of obsessive passion, which in turn foster higher levels of problematic behaviours. Conversely, higher levels of needs satisfaction are likely to promote higher levels of harmonious passion, which predict higher levels of flow experience. This study contributes to the understanding of the motivational pathways that characterise the engagement in screen-based activities and provides evidence that the psychological experience during the activity could lead to a positive or a negative outcome.
Structural, Optical, and Photocatalytic Properties of ZnSe Nanoparticles Influenced by the Milling Time

ZnSe nanoparticles (NPs) were prepared by combining both hydrothermal and mechanical milling methods. Transmission electron microscopy images show that fabricated ZnSe NPs with a sphere-like shape have an average size (d) in the range of 20–100 nm, affected by changing the milling time from 10 to 60 min. All the samples crystalize in zincblende-type structure without impurities, as confirmed by analyzing X-ray diffraction patterns, Raman spectra, and energy-dispersive X-ray spectroscopy. Carefully checking Raman spectra, we have observed the broadening and redshift of vibration modes as decreasing NP size, which are ascribed to extra appearance of disorder and defects. The photoluminescence study has found a blue emission at 462 nm attributed to the excitonic near-band edge and a broad defect-related emission around 520–555 nm. Increasing milling time leads to the decrease in the exciton-emission intensity, while the defect-related emissions increase gradually. Interestingly, as decreasing d, we have observed an improved photodegradation of Rhodamine B under UV irradiation, proving application potentials of ZnSe NPs in photocatalytic activity.
RHAMM-Target Peptides Inhibit Proliferation and Viability of Cancer Cells

The incidence of cancer in the world is growing exponentially. Therefore, the search for targeted cancer therapy methods is the most urgent and actively developing the biomedicine field. This work is devoted to studying RHAMM-target peptides' effect on the proliferation and viability of ovarian cancer, prostate cancer, breast carcinoma, and adenocarcinoma of the breast duct cells. Cell proliferation was examined by a BrdU-based proliferation assay. Cell viability was assayed by the fluorescence method. It has been established that RHAMM-target peptides at a concentration of 2х10-7 M inhibited on ~ 55 % proliferation of MDA-MB-231 cells, on ~ 85 % proliferation of PC3m-LN4, and ~ 50 % proliferation of SKOV3 cells for 24 h. The results showed that the peptides inhibited the viability of ovarian cancer cells. In particular, peptide EEDFGEEAEEEA inhibited ovarian cancer cells' viability by 54%, peptide VEGEGEEGEEY by 63%, and peptide FTEAESNMNDLV by 57%. RHAMM-target peptides did not affect fibroblasts (non-tumor cells) and fibroblasts RHAMM(-/-). This work showed that RHAMM-target peptides at low concentrations of inhibited cancer cells' proliferation and viability. This effect was RHAMM mediated. RHAMM-target peptides are promising candidates for anti-cancer drugs.
Multiple Correspondence Analysis of Wrong-Way Driving Fatal Crashes on Freeways

The objective of this study is to identify clusters of contributing factors associated with the occurrence of wrong-way driving (WWD) fatal crashes on freeways using the multiple correspondence analysis (MCA) method based on the Burt matrix with an adjustment of inertias. A total of 14 years (2004–2017) of WWD fatal crash data were extracted from the National Highway Traffic Safety Administration (NHTSA) Fatality Analysis Reporting System (FARS) database. A standard procedure was developed to extract the WWD crash information (including a total of 3,817 crashes) on freeways from the FARS. Each crash contains various characteristics of crashes, vehicles, and drivers, for example, crash time, crash location, vehicle type, driver age, and so forth. The MCA analysis used a total of 19 key variables with 67 defined categories. The results of this study indicate that four clusters of factors which, when combined, might contribute to the occurrence of some WWD fatal crashes. These four clusters were: (1) younger drivers, driving under the influence (DUI), midnight/early morning, lower speed limit (45–50 mph), urban areas, and street lighting; (2) older drivers, non-DUI drivers, and daylight; (3) dark/no light, 18:00 to 23:59 p.m. , higher speed limits (65 mph or more), and rural areas; and (4) rain/snow/sleet/hail/fog, and wet road surface.
First-principles study on the chemical decomposition of inorganic perovskites \ce{CsPbI3} and \ce{RbPbI3} at finite temperature and pressure

Inorganic halide perovskite \ce{Cs(Rb)PbI3} has attracted significant research interest in the application of light-absorbing material of perovskite solar cells (PSCs). Although there have been extensive studies on structural and electronic properties of inorganic halide perovskites, the investigation on their thermodynamic stability is lack. Thus, we investigate the effect of substituting Rb for Cs in \ce{CsPbI3} on the chemical decomposition and thermodynamic stability using first-principles thermodynamics. By calculating the formation energies of solid solutions \ce{Cs$_{1-x}$Rb$_x$PbI3} from their ingredients \ce{Cs$_{1-x}$Rb$_x$I} and \ce{PbI2}, we find that the best match between efficiency and stability can be achieved at the Rb content $x\approx$ 0.7. The calculated Helmholtz free energy of solid solutions indicates that \ce{Cs$_{1-x}$Rb$_x$PbI3} has a good thermodynamic stability at room temperature due to a good miscibility of \ce{CsPbI3} and \ce{RbPbI3}. Through lattice-dynamics calculations, we further highlight that \ce{RbPbI3} never stabilize in cubic phase at any temperature and pressure due to the chemical decomposition into its ingredients \ce{RbI} and \ce{PbI2}, while \ce{CsPbI3} can be stabilized in the cubic phase at the temperature range of 0$-$600 K and the pressure range of 0$-$4 GPa. Our work reasonably explains the experimental observations, and paves the way for understanding material stability of the inorganic halide perovskites and designing efficient inorganic halide PSCs.
The Gut Microbiota Metabolite Urolithin B Improves Cognitive Deficits by Inhibiting Cyt C-Mediated Apoptosis and Promoting the Survival of Neurons Through the PI3K Pathway in Aging Mice

Background: Despite considerable advances in pharmacotherapy, more effective therapeutic interventions for aging-related neurodegenerative disorders (NDs), such as Alzheimer’s disease (AD), remain limited. Urolithin B (UB), one of the major subcategories of urolithins (microbiota metabolites) found in various tissues after ellagitannin consumption, has been shown to possess antioxidant, anti-inflammatory, and antiapoptotic effects. However, the neuroprotective effect of UB on brain aging in mice and its potential mechanisms were still unknown. Methods: In the current research, we first assessed the ameliorative effects of UB on oxidative injury and apoptosis induced by H2O2 in neuro-2a cells. Then a subcutaneous injection of D-galactose in mice for 8 weeks was used to establish the aging model to evaluate the protective effects of UB. The capacity of memory and learning, alterations of hippocampus histology and corresponding molecular mechanisms were all evaluated. Results: The D-gal-induced accelerated aging model in vivo demonstrated that UB could significantly ameliorate deficits in learning and memory by inhibiting the accumulation of advanced glycation end products (AGEs) and elevating the expression and activity of Cu, Zn-SOD and CAT. Furthermore, UB downregulated the c-Jun N-terminal kinase (JNK) signaling pathway and prevented cytochrome c release from isolated mitochondria, thereby inhibiting neuronal apoptosis during the aging process. More importantly, UB stimulation of aging mice activated ERK and phosphoinositide 3-kinase (PI3K), leading to neuronal survival along with Akt and p44/42 mitogen-activated protein kinase (MAPK) phosphorylation and activation. Conclusion: In summary, UB effectively alleviated cognitive deficits and ameliorated brain aging-related conditions and could be considered a healthcare product to prevent aging-associated NDs such as AD.
The Role of Firm’s Location, Export-Related Resources and Capabilities in Relation to Coffee & Sesame Export Performance in Ethiopia

Exporting has been one of the fastest foreign expansion strategies in the last two decades. The purpose of this study is to investigate the role of an exporter's location in the development of export-related resources and capabilities, which will have an impact on the degree of export performance. The relationship between export-related resources, capabilities, and export performance are examined in this study. A total of 300 questionnaires were sent out to coffee and sesame exporters. However, only 253 surveys were used for analysis. The SmartPLS 3 software was used to analyse the data using the Partial Least Squares (PLS) technique. The study's findings suggest that access to location-specific resources and skills are critical antecedents for a company's ability to build export-related resources and capabilities in order to improve export performance. The geographic location of a company has a considerable and beneficial impact on human resource capability (β =0.67, p=0.001). Information capability was not significantly influenced by human resource capability ((β =0.082, P=0.259). Information capability ((β =0.656, p=0.001) is significantly influenced by organizational planning capability ((β =0.452, p=0.001). Satisfaction Export Performance ((β =0.431, p=0.01) has been significantly and positively influenced by information capability. New Product Development Capability influences strategic export performance significantly and positively ((β =0.330, p=0.001). Strategic export performance ((β =-0.035, P= 0.820) and satisfaction with export performance ((β =0.050, P= 0.625) were not affected by relationship capability. These data suggest that when it comes to exporting, rural businesses face significantly greater obstacles than those in metropolitan areas. The outcomes of this study will assist managers of remote-area businesses in developing equally appealing recruitment and reward practices in order to compete with businesses in urban areas. Furthermore, the outcomes of this study advise that export firm managers think carefully about the resources and capabilities required to improve their export performance.
Health-Related Quality of Life Among Pregnant Women With Pre-pregnancy Smoking and Smoking Cessation During Pregnancy in China: National Cross-sectional Study

Background Previous studies have hardly explored the influence of pre-pregnancy smoking and smoking cessation during pregnancy on the health-related quality of life (HRQoL) of pregnant women, which is a topic that need to be addressed. In addition, pregnant women in China constitute a big population in the largest developing country of the world and cannot be neglected. Objective This study aims to evaluate the HRQoL of pregnant women in China with different smoking statuses and further estimate the association between pre-pregnancy smoking, smoking cessation, and the HRQoL. Methods A nationwide cross-sectional study was conducted to determine the association between different smoking statuses (smoking currently, quit smoking, never smoking) and the HRQoL in pregnant women across mainland China. A web-based questionnaire was delivered through the Banmi Online Maternity School platform, including questions about demographics, smoking status, and the HRQoL. EuroQoL Group’s 5-dimension 5-level (EQ-5D-5L) scale with EuroQoL Group’s visual analog scale (EQ-VAS) was used for measuring the HRQoL. Ethical approval was granted by the institutional review board of the First Affiliated Hospital of Sun Yat-sen University (ICE-2017-296). Results From August to September 2019, a total of 16,483 participants from 31 provinces were included, of which 93 (0.56%) were smokers, 731 (4.43%) were ex-smokers, and 15,659 (95%) were nonsmokers. Nonsmokers had the highest EQ-VAS score (mean 84.49, SD 14.84), smokers had the lowest EQ-VAS score (mean 77.38, SD 21.99), and the EQ-VAS score for ex-smokers was in between (mean 81.04, SD 17.68). A significant difference in EQ-VAS scores was detected between nonsmokers and ex-smokers (P<.001), which indicated that pre-pregnancy smoking does have a negative impact on the HRQoL (EQ-VAS) of pregnant women. Compared with nonsmokers, ex-smokers suffered from more anxiety/depression problems (P=.001, odds ratio [OR] 1.29, 95% CI 1.12-1.50). Among ex-smokers, the increased cigarette consumption was associated with a lower EQ-5D index (P=.007) and EQ-VAS score (P=.01) of pregnant women. Compared to smokers, no significant difference was found in the ex-smokers’ EQ-5D index and EQ-VAS score (P=.33). Conclusions Smoking history is associated with a lower HRQoL in pregnant Chinese women. Pre-pregnancy smoking is related to a lower HRQoL (EQ-VAS) and a higher incidence of depression/anxiety problems. Smoking cessation during pregnancy does not significantly improve the HRQoL of pregnant Chinese women. Among ex-smokers, the more cigarettes they smoke, the lower HRQoL they have during pregnancy. We suggest that the Chinese government should strengthen the education on quitting smoking and avoiding second-hand smoke for women who have pregnancy plans and their family members.
Quality of plant-based ground beef alternatives in comparison to ground beef of various fat levels

The objective of this study was to compare the quality characteristics of current plant-based protein ground beef alternatives (GBA) to ground beef (GB) patties of varying fat percentages. Fifteen different production lots (n = 15 / fat level) of 1.36 kg GB chubs of three different fat levels (10%, 20%, and 27%) were collected from retail markets in the Manhattan, KS area. Additionally, GBA products including a foodservice GBA (FGBA), a retail GBA (RGBA), and a traditional soy-protein based GBA (TGBA) currently available through commercial channels were collected. Consumers (n = 120) evaluated sample appearance, juiciness, tenderness, overall flavor liking, beef flavor liking, texture liking, and overall liking. Additionally, samples were evaluated for color, texture profile, shear force, pressed juiciness percentage (PJP), pH, and fat and moisture percentage. All three GB samples rated higher (P < 0.05) than the three GBA samples for appearance liking, overall flavor liking, beef flavor liking, and overall liking by consumers. Similar results were found with trained sensory panelists, which rated the GBA as less (P < 0.05) juicy, softer (P < 0.05), and lower (P < 0.05) for beef flavor and odor intensity and higher (P < 0.05) for off-flavor intensity than the GB. Moreover, the GBA had less (P < 0.05) change in shape through cooking and a lower (P < 0.05) percentage of cooking loss and cooking time than the GB. Also, the GBA all had lower (P < 0.05) shear force and PJP values than the GB. The color of the GBA differed (P < 0.05) from the GB, with the GB samples being more (P < 0.05) red in the raw state. These results indicate that the GBA provide different eating and quality experiences than GB and should thus be considered as different products by consumers and retailers.
Assessment of the Effects of Newly Fabricated CaO, CuO, ZnO Nanoparticles on Callus Formation Maintainance of Alfalfa (Medicago Sativa L.) Under In Vitro Salt Stress

Nanoparticules plays an important role in plant adaptation to abiotic stress, especially in response to salt stress. In this study, two alfalfa lines (Erzurum, and Muş) were used as the material for the response NaCl to CuO, ZnO and CaO nanoparticules (NPs). CaO is evident to be higher effective than CuO, ZnO in callus induction from leaf explants. The antioxidant enzyme activities were also determined in the callus cultures. The maximum activity in MDA analysis was observed from callus treated of 50 mM NaCl with 0.8 ppm CuO NPs. The callus induction stage without salt treatments indicated a best result in 0.8 ppm CaO NPs for H2O2 value compared to the other NPs. The callus induction stage without salt treatments indicated a best result in 0.8 ppm CaO NPs for POD value compared to the other NPs for POD activity. The best response in protein rate was obtained from callus induction stage and callus formation stage after 50 mM treatment NaCl with 0.8 ppm CuO. LSCM analysis evident that the NPs could migitate the negative effects of NaCl stress by the elimination of stress severity in callus cells. SEM analysis was supported the results obtained by LSCM analysis. Our findings suggest that CuO, CaO and ZnO NPs can offer a simple and effective method to protect alfalfa callus from NaCl stress severity.