Miracle-dz/UniFAR-FTUs huggingface dataset:
ournal of C osmology and A stroparticle hysics J Eﬀect of clustering on primordial black hole microlensing constraints

Stellar microlensing observations tightly constrain compact object dark matter in the mass range (10 − 11 –10 3 ) M (cid:12) . Primordial Black Holes (PBHs) form clusters, and it has been argued that these microlensing constraints are consequently weakened or evaded. For the most commonly studied PBH formation mechanism, the collapse of large gaussian curvature perturbations generated by inﬂation, the clusters are suﬃciently extended that the PBHs within them act as individual lenses. We ﬁnd that if the typical mass of the clusters is suﬃciently large, (cid:38) 10 6 M (cid:12) , then the event duration distribution can deviate signiﬁcantly from that produced by a smooth dark matter distribution, in particular at the shortest durations. As a consequence of this, the probability distribution of the number of observed events is non-Poissonian, peaking at a lower value, with an extended tail to large numbers of events. However, for PBHs formed from the collapse of large inﬂationary perturbations, the typical cluster is expected to contain ∼ 10 3 PBHs. In this case the eﬀect of clustering is negligibly small, apart from for the most massive PBHs probed by decade-long stellar microlensing surveys ( M PBH ∼ 10 3 M (cid:12) ).
When Will Arctic Sea Ice Disappear? Projections of Area, Extent, Thickness, and Volume

Rapidly diminishing Arctic summer sea ice is a strong signal of the pace of global climate change. We provide point, interval, and density forecasts for four measures of Arctic sea ice: area, extent, thickness, and volume. Importantly, we enforce the joint constraint that these measures must simultaneously arrive at an ice-free Arctic. We apply this constrained joint forecast procedure to models relating sea ice to atmospheric carbon dioxide concentration and models relating sea ice directly to time. The resulting"carbon-trend"and"time-trend"projections are mutually consistent and predict a nearly ice-free summer Arctic Ocean by the mid-2030s with an 80% probability. Moreover, the carbon-trend projections show that global adoption of a lower carbon path would likely delay the arrival of a seasonally ice-free Arctic by only a few years.
Small-time local controllability of the bilinear Schr\"odinger equation, despite a quadratic obstruction, thanks to a cubic term

We consider a 1D linear Schr{\"o}dinger equation, on a bounded interval, with Dirichlet boundary conditions and bilinear control. We study its controllability around the ground state when the linearized system is not controllable. More precisely, we study to what extent the nonlinear terms of the expansion can recover the directions lost at the first order.In previous works, for any positive integer $n$, assumptions have been formulated under which the quadratic term induces a drift in the nonlinear dynamics, quantified by the $H^{-n}$ norm of the control. This drift is an obstruction to the small-time local controllability (STLC) under a smallness assumption on the controls in regular spaces. In this paper, we prove that for controls small in less regular spaces, the cubic term can recover the controllability lost at the linear level, despite the quadratic drift. The proof is inspired by Sussman's method to prove the sufficiency of the $\mathcal{S}(\theta)$ condition for STLC of ODEs. However, it uses a different global strategy relying on a new concept of tangent vector, better adapted to the infinite-dimensional setting of PDEs. Given a target, we first realize the expected motion along the lost direction by using control variations for which the cubic term dominates the quadratic one. Then, we correct the other components exactly, by using a STLC in projection result, with simultaneous estimates of weak norms of the control. These estimates ensure that the new error along the lost direction is negligible, and we conclude with the Brouwer fixed point theorem.
Quadruped Guidance Robot for the Visually Impaired: A Comfort-Based Approach

Guidance robots that can guide people and avoid various obstacles, could potentially be owned by more visually impaired people at a fairly low cost. Most of the previous guidance robots for the visually impaired ignored the human response behavior and comfort, treating the human as an appendage dragged by the robot, which can lead to imprecise guidance of the human and sudden changes in the traction force experienced by the human. In this paper, we propose a novel quadruped guidance robot system with a comfort-based concept. We design a controllable traction device that can adjust the length and force between human and robot to ensure comfort. To allow the human to be guided safely and comfortably to the target position in complex environments, our proposed human motion planner can plan the traction force with the force-based human motion model. To track the planned force, we also propose a robot motion planner that can generate the specific robot motion command and design the force control device. Our system has been deployed on Unitree Laikago quadrupedal platform and validated in real-world scenarios. (Video11Video demonstration: https://youtu.be/gd-RcYOqGuo.)
Incorporating Hierarchy into Text Encoder: a Contrastive Learning Approach for Hierarchical Text Classification

Hierarchical text classification is a challenging subtask of multi-label classification due to its complex label hierarchy. Existing methods encode text and label hierarchy separately and mix their representations for classification, where the hierarchy remains unchanged for all input text. Instead of modeling them separately, in this work, we propose Hierarchy-guided Contrastive Learning (HGCLR) to directly embed the hierarchy into a text encoder. During training, HGCLR constructs positive samples for input text under the guidance of the label hierarchy. By pulling together the input text and its positive sample, the text encoder can learn to generate the hierarchy-aware text representation independently. Therefore, after training, the HGCLR enhanced text encoder can dispense with the redundant hierarchy. Extensive experiments on three benchmark datasets verify the effectiveness of HGCLR.
The Dangers of Underclaiming: Reasons for Caution When Reporting How NLP Systems Fail

Researchers in NLP often frame and discuss research results in ways that serve to deemphasize the field’s successes, often in response to the field’s widespread hype. Though well-meaning, this has yielded many misleading or false claims about the limits of our best technology. This is a problem, and it may be more serious than it looks: It harms our credibility in ways that can make it harder to mitigate present-day harms, like those involving biased systems for content moderation or resume screening. It also limits our ability to prepare for the potentially enormous impacts of more distant future advances. This paper urges researchers to be careful about these claims and suggests some research directions and communication strategies that will make it easier to avoid or rebut them.
Clinical improvement after surgery for degenerative cervical myelopathy; A comparison of Patient-Reported Outcome Measures during 12-month follow-up

Object Although many patients report clinical improvement after surgery due to degenerative cervical myelopathy, the aim of intervention is to stop progression of spinal cord dysfunction. We wanted to provide estimates and assess achievement rates of Minimal Clinically Important Difference (MCID) at 3- and 12-month follow-up for Neck Disability Index (NDI), Numeric Rating Scale for arm pain (NRS-AP) and neck pain (NRS-NP), Euro-Qol (EQ-5D-3L), and European Myelopathy Score (EMS). Methods 614 degenerative cervical myelopathy patients undergoing surgery responded to Patient-Reported Outcome Measures (PROMs) prior to, 3 and 12 months after surgery. External criterion was the Global Perceived Effect Scale (1–7), defining MCID as “slightly better”, “much better” and “completely recovered”. MCID estimates with highest sensitivity and specificity were calculated by Receiver Operating Curves for change and percentage change scores in the whole sample and in anterior and posterior procedural groups. Results The NDI and NRS-NP percentage change scores were the most accurate PROMs with a MCID of 16%. The change score for NDI and percentage change scores for NDI, NRS-AP and NRS-NP were slightly higher in the anterior procedure group compared to the posterior procedure group, while remaining PROM estimates were similar across procedure type. The MCID achievement rates at 12-month follow-up ranged from 51% in EMS to 62% in NRS-NP. Conclusion The NDI and NRS-NP percentage change scores were the most accurate PROMs to measure clinical improvement after surgery for degenerative cervical myelopathy. We recommend using different cut-off estimates for anterior and posterior approach procedures. A MCID achievement rate of 60% or less must be interpreted in the perspective that the main goal of surgery for degenerative cervical myelopathy is to prevent worsening of the condition.
What are we learning about HIV testing in informal settlements in KwaZulu-Natal, South Africa? Results from a randomized controlled trial

Background Recent evidence highlighting high HIV incidence and prevalence in informal settlements suggests that they are environments that foster HIV risk. Given growing urbanization in sub-Saharan Africa, there is a critical need to assess the successes and challenges of implementing HIV testing, prevention and treatment interventions in these contexts. Methods We randomly selected a household-based sample of 1528 adult men (18–35) and women (18–24) living in 18 randomly selected communities in KZN, South Africa. After the baseline interview, communities were randomized to one of three intervention rollout arms in a stepped wedge design. At approximately 8-month intervals, the Asibonisane Community Responses Program (and in particular the implementation of Stepping Stones, a participatory HIV prevention program focused on strengthening relationships and communication) was rolled at by intervention phase. Using data from this evaluation, we describe levels and trends in HIV testing and treatment during follow-up, and we use fixed effects models to estimate the effects of participation in the program on testing. Results Study respondents reported high levels of economic insecurity and mobility, and men report various HIV risk behaviors including about 50% reporting multiple partnerships. About two-thirds of respondents (73% of women, 63% of men) had been tested for HIV in the last six months. Among those living with HIV, treatment levels were high at baseline, and almost universal by endline in 2019. Program participation led to a 17% increase in the probability of testing for women (p<0.05) but had no effect on testing for men due, in part, to the fact that the program did not reach men who were least likely to be tested, including those who had migrated recently, and those who had never been tested at baseline. Conclusions Near universal HIV treatment use demonstrates positive trends in access to some HIV services (including treatment as prevention) in these communities. Stepping Stones had positive effects on HIV testing for women, yet barriers to HIV testing remain, especially for men. Redoubled efforts to reach men with testing are vital for improving HIV outcomes for both men and their partners.
Filarids (Spirurida: Onchocercidae) in wild carnivores and domestic dogs from the Brazilian Atlantic forest

Onchocercidae nematodes are heteroxenous parasites with worldwide distribution, and some of the species associated to animals may present zoonotic potential. Climatic changes and anthropic influences on the environment may result in vectors’ proliferation, facilitating the spillover to humans and/or non-typical animal hosts. The Iguaçu National Park (PARNA Iguaçu), one of the most important Brazilian natural remanescents of Atlantic rainforest, is strongly affected by human activities such as tourism and agriculture. The complexity of this area is especially characterized by the close nexus between the rich wildlife, humans, and domestic animals, especially domestic dogs. Based on this, this research aimed to diagnose the Onchocercidae nematodes in wild carnivores and domestic dogs in the PARNA Iguaçu and the surrounding areas. For this, we collected 162 samples of seven species of wild carnivores and 225 samples of domestic dogs. The presence of microfilariae in the blood samples was diagnosed by the modified Knott’s test and molecular screening, and the specific identification was based on sequencing of the myoHC and hsp70 genes. Microfilariae were detected only in ring-tailed coatis, in which we found five species: Mansonella sp. 1, Mansonela sp. 2, Onchocercidade gen. sp. 1, Onchocercidade gen. sp. 2, and Dirofilaria immitis. The morphological analysis supported the molecular findings. The domestic dogs were parasitized by Acanthocheilonema reconditum, representing a new locality record for this species. Phylogenetic analysis showed high genetic similarity among the four undetermined species and Mansonella spp. , Brugia spp. , and Wuchereria bancrofti. The presence of D. immitis in ring-tailed coatis may be result of spillover from dogs, even though the parasite was not diagnosed in the sampled dogs. The presence of several undetermined Onchocercidae species indicates the necessity of continuous investigations on wild and domestic animals from Neotropical area, especially considering the growing anthropic influence on forest remnants.
Cost-effectiveness and budget impact analysis of siponimod in the treatment of secondary progressive multiple sclerosis in Italy

Background Siponimod is an effective treatment for patients with secondary progressive multiple sclerosis (SPMS), with active disease evidenced by relapses or imaging features characteristic of multiple sclerosis inflammatory activity, however there is a need to evaluate its economic value and sustainability compared to other disease modifying-therapies (DMTs). Objective To estimate the siponimod cost-effectiveness profile and its relative budget impact compared with other DMTs, by using the Italian National Healthcare System perspective. Methods We performed: 1) a cost-effectiveness analysis (CEA) vs interferon beta-1b using an analytical Markov model and a life time-horizon, and 2) a budget impact analysis by using 3-years time-horizon. The results were reported as incremental cost-effectiveness ratio (ICER) and net-monetary benefit (NMB) for CEA, using a willingness to pay threshold of €40,000 per QALY gained, and as difference in the overall budget (Euro) between the scenario with and without siponimod for budget impact. Results In the base case scenario siponimod resulted cost-effective compared with interferon beta-1b 28,891€ per QALY. Overall, the market access of siponimod was associated to an increased budget of about 3€ millions (+0.9%) in the next 3 years simulated. Conclusion Compared to interferon beta-1b, siponimod seems to be cost-effective in SPMS patients and sustainable, with less than 1% overall budget increased in the next 3 years. Future studies need to confirm our results in the real word setting and in other countries.
SARM1 participates in axonal degeneration and mitochondrial dysfunction in prion disease

Prion disease represents a group of fatal neurogenerative diseases in humans and animals that are associated with energy loss, axonal degeneration, and mitochondrial dysfunction. Axonal degeneration is an early hallmark of neurodegeneration and is triggered by SARM1. We found that depletion or dysfunctional mutation of SARM1 protected against NAD+ loss, axonal degeneration, and mitochondrial functional disorder induced by the neurotoxic peptide PrP106–126. NAD+ supplementation rescued prion-triggered axonal degeneration and mitochondrial dysfunction and SARM1 overexpression suppressed this protective effect. NAD+ supplementation in PrP106–126-incubated N2a cells, SARM1 depletion, and SARM1 dysfunctional mutation each blocked neuronal apoptosis and increased cell survival. Our results indicate that the axonal degeneration and mitochondrial dysfunction triggered by PrP106–126 are partially dependent on SARM1 NADase activity. This pathway has potential as a therapeutic target in the early stages of prion disease.
Precarious Employment and Self-Rated Health in Young Adults

This longitudinal study revealed a significant association between precarious employment (PE) and poor self-rated health (SRH), especially in young male adults. There is an urgent need to consider improving the health of young workers in PE and the quality of employment for young people who are vulnerable to PE. Objective To investigate the relationship between employment changes including sustained precarious employment (PE) and poor self-rated health (SRH) in young Korean adults. Methods: A longitudinal study was performed using follow-up data from the Korea Youth Panel Survey 2007 (3rd–12th). Overall, 1265 young adults were included. Multiple logistic regression analyses estimated the poor SRH risk according to employment changes. Results Poor SRH risk was significantly higher in sustained PE than in fulltime permanent employment in young male adults and overall. However, in young female adults, PE was not clearly associated with poor SRH risk. Conclusions The proportion of new cases of poor SRH was increased by PE, particularly in young male workers. This finding emphasizes the importance of improving the health of young workers with PE and employment quality for young people vulnerable to PE.
Noise Reduction Learning Based on XLNet-CRF for Biomedical Named Entity Recognition

In recent years, Biomedical Named Entity Recognition (BioNER) systems have mainly been based on deep neural networks, which are used to extract information from the rapidly expanding biomedical literature. Long-distance context autoencoding language models based on transformers have recently been employed for BioNER with great success. However, noise interference exists in the process of pre-training and fine-tuning, and there is no effective decoder for label dependency. Current models have many aspects in need of improvement for better performance. We propose two kinds of noise reduction models, Shared Labels and Dynamic Splicing, based on XLNet encoding which is a permutation language pre-training model and decoding by Conditional Random Field (CRF). By testing 15 biomedical named entity recognition datasets, the two models improved the average F1-score by 1.504 and 1.48, respectively, and state-of-the-art performance was achieved on 7 of them. Further analysis proves the effectiveness of the two models and the improvement of the recognition effect of CRF, and suggests the applicable scope of the models according to different data characteristics.
Comprehensive mouse microbiota genome catalog reveals major difference to its human counterpart

Mouse is the most used model for studying the impact of microbiota on its host, but the repertoire of species from the mouse gut microbiome remains largely unknown. Accordingly, the similarity between human and mouse microbiomes at a low taxonomic level is not clear. We construct a comprehensive mouse microbiota genome (CMMG) catalog by assembling all currently available mouse gut metagenomes and combining them with published reference and metagenome-assembled genomes. The 41’798 genomes cluster into 1’573 species, of which 78.1% are uncultured, and we discovered 226 new genera, seven new families, and one new order. CMMG enables an unprecedented coverage of the mouse gut microbiome exceeding 86%, increases the mapping rate over four-fold, and allows functional microbiota analyses of human and mouse linking them to the driver species. Comparing CMMG to microbiota from the unified human gastrointestinal genomes shows an overlap of 62% at the genus but only 10% at the species level, demonstrating that human and mouse gut microbiota are largely distinct. CMMG contains the most comprehensive collection of consistently functionally annotated species of the mouse and human microbiome to date, setting the ground for analysis of new and reanalysis of existing datasets at an unprecedented depth.
Cranial irradiation impairs intrinsic excitability and synaptic plasticity of hippocampal CA1 pyramidal neurons with implications for cognitive function

Radiation therapy is a standard treatment for head and neck tumors. However, patients often exhibit cognitive impairments following radiation therapy. Previous studies have revealed that hippocampal dysfunction, specifically abnormal hippocampal neurogenesis or neuroinflammation, plays a key role in radiation-induced cognitive impairment. However, the long-term effects of radiation with respect to the electrophysiological adaptation of hippocampal neurons remain poorly characterized. We found that mice exhibited cognitive impairment 3 months after undergoing 10 minutes of cranial irradiation at a dose rate of 3 Gy/min. Furthermore, we observed a remarkable reduction in spike firing and excitatory synaptic input, as well as greatly enhanced inhibitory inputs, in hippocampal CA1 pyramidal neurons. Corresponding to the electrophysiological adaptation, we found reduced expression of synaptic plasticity marker VGLUT1 and increased expression of VGAT. Furthermore, in irradiated mice, long-term potentiation in the hippocampus was weakened and GluR1 expression was inhibited. These findings suggest that radiation can impair intrinsic excitability and synaptic plasticity in hippocampal CA1 pyramidal neurons.
Cyphoderia ampulla (Cyphoderiidae: Rhizaria), a tale of freshwater sailors: The causes and consequences of ecological transitions through the salinity barrier in a family of benthic protists

The salinity barrier that separates marine and freshwater biomes is probably the most important division in biodiversity on Earth. Those organisms that successfully performed this transition had access to new ecosystems while undergoing changes in selective pressure, which often led to major shifts in diversification rates. While these transitions have been extensively investigated in animals, the tempo, mode, and outcome of crossing the salinity barrier have been scarcely studied in other eukaryotes. Here, we reconstructed the evolutionary history of the species complex Cyphoderia ampulla (Euglyphida: Cercozoa: Rhizaria) based on DNA sequences from the nuclear SSU rRNA gene and the mitochondrial cytochrome oxidase subunit I gene, obtained from publicly available environmental DNA data (GeneBank, EukBank) and isolated organisms. A tree calibrated with euglyphid fossils showed that four independent transitions towards freshwater systems occurred from the mid‐Miocene onwards, coincident with important fluctuations in sea level. Ancestral trait reconstructions indicated that the whole family Cyphoderiidae had a marine origin and suggest that ancestors of the freshwater forms were euryhaline and lived in environments with fluctuating salinity. Diversification rates did not show any obvious increase concomitant with ecological transitions, but morphometric analyses indicated that species increased in size and homogenized their morphology after colonizing the new environments. This suggests adaptation to changes in selective pressure exerted by life in freshwater sediments.