Miracle-dz/UniFAR-FTUs huggingface dataset:
Blood order and collection problems with two demand classes and emergency replenishment

Abstract Matching blood supply and demand in an efficient manner is the key to minimize the shortage and waste in blood supply chain management. Blood heterogeneous demand further increases the difficulty and brings much challenges to blood supply chain management. To alleviate above problems, we build blood ordering and collection models in blood supply chain under two emergency replenishment strategies by considering blood heterogeneous demand. The blood heterogeneous demand is modelled as two demand classes, i.e., high-priority stochastic emergency demand and low-priority regular deterministic demand. We examine the optimal ordering policy of the hospital and optimal collection policy of the blood center. The effect of different emergency replenishment strategies and high-priority stochastic emergency demand fluctuation are analysed. Through numerical analysis, we find that facing a low demand fluctuation, the hospital prefers to order enough blood instead of replenishing during the period, while the blood center prefers to provide emergency replenishment for both demands. In the situation of high fluctuation, emergency replenishment for both demands is the best for the hospital while the blood center would not like to provide replenishment and hope the hospital to order for once. However, emergency replenishment for both demands is always better off for the entire blood supply chain. The hospital and blood center can be coordinated to agree on the emergency replenishment for both demands and a Pareto improvement can be achieved.
The role of extra and intra vascular cells and theirmolecules in modulating glomerular inflammationduring health and disease

Endothelium forms an interface between vasculature and cellular sub endothelial environment responding to the changes in the immediate environment in health and disease. During vasculitic glomerulonephritis (VGN), autoantibodies raised against neutrophil serine proteases (SP) activate the neutrophils resulting in the release of neutrophilic products onto the endothelial surface changing its ability to support neutrophil recruitment and leading to its damage. We have hypothesized that endothelial functions are modulated by intra and extracellular environments of the vasculature and that the glomerular epithelial cells (podocytes) regulate glomerular endothelial cell (GEnC) functions. This work investigated the effects of SP (Proteinase-3 (PR3) and human neutrophil elastase (HNE)) in mediating neutrophil recruitment on EnC prior to the development of injury in a concentration and time dependent fashion. Most of the effects were inhibitable by the presence of α1-antitrypsin (α1-AT). Further, using an in vitro static co-culture system, this work demonstrates an endogenous mechanism by which podocytes modulate endothelial response to inflammatory stimuli in the glomerulus under healthy and disease conditions. Overall, these studies elucidate that GEnC presents an adhesive phenotype attracting neutrophils under the influence of inflammatory cytokines. During disease conditions as in VGN, exposure of endothelium to SPs results in a pre-activation stage leading to damage with high and/or prolonged exposures. Podocytes modulate glomerular endothelial responses to cytokine stimulation in health and disease. Thus, endothelial functions are tightly regulated by interacting cells and their molecules and could be an important phenomenon in the disease process of VGN where neutrophil recruitment plays a central pathogenic role.
A Two-stage Deep Domain Adaptation Method for Hyperspectral Image Classification

Deep learning has attracted extensive attention in the field of hyperspectral images (HSIs) classification. However, supervised deep learning methods heavily rely on a large amount of label information. To address this problem, in this paper, we propose a two-stage deep domain adaptation method for hyperspectral image classification, which can minimize the data shift between two domains and learn a more discriminative deep embedding space with very few labeled target samples. A deep embedding space is first learned by minimizing the distance between the source domain and the target domain based on Maximum Mean Discrepancy (MMD) criterion. The Spatial–Spectral Siamese Network is then exploited to reduce the data shift and learn a more discriminative deep embedding space by minimizing the distance between samples from different domains but the same class label and maximizes the distance between samples from different domains and class labels based on pairwise loss. For the classification task, the softmax layer is replaced with a linear support vector machine, in which learning minimizes a margin-based loss instead of the cross-entropy loss. The experimental results on two sets of hyperspectral remote sensing images show that the proposed method can outperform several state-of-the-art methods.
Egg Development and Larvae of the Snailfish, Liparis tanakai (Gilbert et Burke)

Snailfish, Liparis tanakai (Gilbert et Burke) is widely distributed in the coastal waters of Korea and Japan. On December 21, 1985, fertilized eggs of the fish were collected from the coastal waters of Saryang-do island, Kyongsangnam-do, Korea, and the eggs were incubated and the larvae reared at a mean water temperature of in the laboratory. The fertilized eggs of this species are demersal, adhesive and spherical in shape, measuring (mean 1.72mm, n=30) in diameter, containing about 20 oil globules. Hatching took place 21 days after blastula stage. During the incubation period water temperature fluctuated between . The newly hatched larvae were (mean 6.10mm, n=30) in total length with (abdominal) and 36 (caudal) myomeres. Many melanophores were distributed on the large pectoral fin, yolk sac and peritoneum. Twelve days after hatching, the larvae attained in total length, and at this time the larvae absorbed the yolk almost completely. Melanophores appeared on the snout and the posterior part of head.
Repowering Steel Tubular Wind Turbine Towers Enhancing them by Internal Stiffening Rings

This paper presents a robust repowering approach to the structural response of tubular steel wind turbine towers enhanced by internal stiffening rings. First, a structural response simulation model was validated by comparison with the existing experimental data. This was then followed with a mesh density sensitivity analysis to obtain the optimum element size. When the outdated wind turbine system needs to be upgraded, the wall thickness, the mid-section width-to-thickness ratio and the spacing of the stiffening rings of wind turbine tower were considered as the critical design variables for repowering. The efficiency repowering range of these design variables of wind turbine towers of various heights between 50 and 250 m can be provided through the numerical analysis. Finally, the results of efficiency repowering range of design variables can be used to propose a new optimum design of the wind turbine system when repowering a wind farm.
The Impact of Geriatric Assessment on Patient Outcomes in Radiation Oncology: A Pilot Study

Introduction: The objective of this pilot study was to obtain preliminary data on the efficacy and feasibility of incorporating geriatric assessment (GA) into radiation oncology (RO) with regard to patient outcomes and treatment decisions. Materials and Methods: Feasibility was assessed via the percentage of patients able to complete certain aspects of the assessment on their own, or with the assistance of a carer before appointments, was recorded. Consultation times and referrals were also documented. All participants (n=30) underwent GA at baseline, before randomisation to the intervention/control arm and commencement of radiotherapy treatment planning procedures. The results of GA were relayed to the Radiation Oncologist (RO) for the intervention arm only. GA was repeated for each participant three months after the completion of radiotherapy. Results: There was some evidence of increasing dependence, at three month follow-up, in ADLs and IADLs, less mobility (TUG score), higher GDS scores and increased vulnerability. However, these were not statistically significant. All patients underwent their predefined radiotherapy treatment plan, without modification. A number of deficits on GA were identified that may be considered significant for older patients. Conclusion: The impact on decision making may reflect a lack of experience and familiarity with GA and how to interpret it, as well as an obvious gap in the literature as to how it affects radiotherapy patient outcomes.
Shell‐shape variation along the latitudinal range of the Chilean blue mussel Mytilus chilensis (Hupe 1854)

Abs tra ctShell -sh ap e variation in th e C h ilean blue m u sselMyt ilu s chi len sis w as exam ined in eight popu la-tions coverin g th e tota lity of its distribu tion ran ge,which repr esen ts ov er 1800 km of la titu din al gradi-en t in the sou thea ste rn Paci¢c . The sh ell ou tlinesh ap es w ere assessed us in g elliptic Fou rier an alysisfollow ed by can on ica l variates an a lysis. Fou riercoeU cien ts show ed a h igh ly sign i¢ca n t m orpholo gi-cal variation be tw een the popu lations stud ied.Ca n on ica lva riates an alysis show ed a visu alassocia-tion of th e First ca n on ica l w ith con vexity of ven traledge an d u mbo sh ap e,w h ile the second axis w as as-sociated w ith sh ell elon gation . P reviously describe dge net ic pa tterns were m argin ally con gru en t w ithou r m orphomet ric pattern , thou gh ge o graph ic dis-ta n ce h ad a stron ge r eAect on m orphol ogy . Sh apech an ge (elon gation ) w as correlated w ith latitu din alclin alvariation . The m orphomet rica lan alysis provedto be an im portan t to ol for ev alu atin g th e com po -ne n ts of shell -sh ape va riation in m u ssels and todocu me n t association pa tterns w ith ge ogr aph ica lan d ecolo gica lva riables. Such pa tterns a re u sefu ltoestablish a w ide ¢eld ofw ork ,in clu d in g sexin g,sto ckrec og n ition , traceab ility stu dies an d prod uc tivem an age me n t in ge ner al.K e y w ord s: in ter-grou p d iscrim in ation , im agea n a lysis, ou tlin es, elliptic Fou rier a n a lysis, ca n on i-cal va riates an alysis, biog eogr aph y, M ytilus chilen-sis,blu e muss elsIntroductionThe C h ilean blue m u ssel Myt ilu s chilensis (H u pe185 4) is w idely distribu ted on h ard subs trates fromth e low er in tertida lzone to depth s o f25 m alon g theC h il ea nco s(Br rþm & Joh 1983). Ir ang e the S E P c i¢c vrs 4 0 1 f l ude ,f rom A ica ( 18 S)to Cape H n56 (La cellott iV et l .6 ) The if-f e rnt iaion pa tte ws c orel ted ith aph -cal d ista n ce, su gges tin g a steppin g-stone m odel ofth e pop u lation stru ctu re. Th is m odel w a s exp ecteddue to th e large dispersalability o flon g-lived plan kto -troph ic la rvae a n d th e pattern o f ocean cu rren tsalon g the C h i le nco s (Toro et .200 4, 0 6) I ad-d ition , a nly sof hell mrphol gy u lnea or -phomet ic v ab l es on three po u ions w nsou ther nC hile ar g how d oupopu lation (P u n ta A ren a s) w as th e m os t d iverge n t(Toro et al.200 4). In th e presen t study w e exam in ed shell m orphol -ogy variation to see if it follow ed th e sa m e pattern ofge net ic m ark ers alon g the 18 00 -k m grad ien t.To da te,m ost m orpholo gica l an alyses of Myti lus sp. shel lsh ave be en ba sed on she ll linea r m orphomet ric
The Efficacy and Safety of Fecal Microbiota Transplant for Recurrent Clostridiumdifficile Infection: Current Understanding and Gap Analysis

Abstract The leading risk factor for Clostridioides (Clostridium) difficile infection (CDI) is broad-spectrum antibiotics, which lead to low microbial diversity, or dysbiosis. Current therapeutic strategies for CDI are insufficient, as they do not address the key role of the microbiome in preventing C. difficile spore germination into toxin-producing vegetative bacteria, which leads to symptomatic disease. Fecal microbiota transplant (FMT) appears to reduce the risk of recurrent CDI through microbiome restoration. However, a wide range of efficacy rates have been reported, and few placebo-controlled trials have been conducted, limiting our understanding of FMT efficacy and safety. We discuss the current knowledge gaps driven by questions around the quality and consistency of clinical trial results, patient selection, diagnostic methodologies, use of suppressive antibiotic therapy, and methods for adverse event reporting. We provide specific recommendations for future trial designs of FMT to provide improved quality of the clinical evidence to better inform treatment guidelines.
Valuation on financial markets: Calculations of emotions and emotional calculations

How do actors on financial markets transform the plethora of informational signals into concrete valuations of traded assets? How do they make decisions in an environment characterized by fundamental uncertainty? Although there is a rich tradition in economic sociology suggesting that emotions and other subjective factors play a decisive role in this regard, empirical studies of their relevance for economic action have remained rare. The present study seeks to fill this void. It investigates the emotional underpinnings of the practices of financial valuation in the German financial sector. Drawing on in-depth interviews with, and ethnographic observations of day traders and fund managers, the study shows that emotions are essential ingredients of their collective calculative practices. Results of the present study yield three empirically grounded key concepts that advance understanding of emotions in financial valuation: First, subjectively experienced market feelings enable traders and managers to imagine imminent market futures. Second, market sentiments reflect traders’ attributions of specific emotional qualities to financial markets and facilitate their understanding of market behaviour. Third, floor emotions are collective emotions in which traders become involved in organizations and on trading floors that help mitigate situational uncertainty.
Emotional bonds: Bridging the gap between evolutionary and humanistic accounts of religious belief

Recent years have seen a growing willingness in the evolutionary cognitive science of religion (ECSR) to embrace an inclusive, theoretically pluralistic approach and the emergence of a broad consensus around some key themes that collectively constitute a central theoretical core of the field. Nevertheless, ECSR still raises serious problems for some in the humanities. In exploring the reasons for the perception of conflict between humanistic and cognitive evolutionary approaches to religion, I suggest that both ECSR’s default account of the origins of religion and religion’s role in social bonding rely upon notions of culturally unmediated universal cognitive mechanisms that preclude alternative humanistic explanations. I subsequently suggest that the gap between humanistic approaches and the evolutionary study of religion more broadly conceived may be narrowed by further expanding ECSR to include recent research into the brain opioid theory of social attachment (BOTSA), which emphasises the emotional rather than cognitive basis of religion’s social bonding functions. Finally, I outline a possible evolutionary account of the earliest forms of religious ideas and practices, which decouples the origins of religion from the evolution of specialised cognitive machinery and which humanists are likely to find more amenable than mainstream ECSR.
The impact of lean manufacturing practices on operational and financial performance: the mediating role of agile manufacturing

PurposeThis empirical study aims to explore the link between lean manufacturing practices (total quality management, just-in-time production, just-in-time purchasing, total productive/preventive maintenance), agile manufacturing, and operational and financial performance.Design/methodology/approachData were collected from 205 Tunisian manufacturing firms, and the results were analyzed using structural equation modeling.FindingsThe results indicate that (1) lean manufacturing practices have a direct positive relationship with agile manufacturing except for just-in-time production, (2) agile manufacturing has a positive impact on operational performance and (3) lean manufacturing practices did not seem to contribute directly to operational performance. However, this relationship is significant when it is mediated through agile manufacturing.Research limitations/implicationsThis paper shows practitioners the importance of lean manufacturing practices to support agile manufacturing and the key role of agile manufacturing to ensure operational performance.Originality/valueThis paper presents an innovative approach since it studies simultaneously the three dimensions of lean manufacturing and their relationship with agile manufacturing and organizational performance.
Descriptions of Two New Marine Species of Pleuronema, P. czapikae sp. n. and P. wiackowskii sp. n. (Ciliophora: Scuticociliatida), from the Yellow Sea, North China

Pleuronema is a scuticociliate genus that includes more than 20 species, most of which are marine. The majority of these are known from insufficient morphological studies. During a recent survey of sand-dwelling ciliates in coastal waters of the Yellow Sea, China, two undescribed scuticociliates were isolated from a beach at Qingdao. Based on observations in vivo and following silver impregnation, it was found that these represent two new members of the genus Pleuronema, P. czapikae and P. wiackowskii, both of which possess a unique combination of characters relating to the oral ciliature and the nuclear apparatus. Compared with its congeners, P. czapikae can be clearly recognized by having a coronatum-type oral apparatus and 6-16 globular macronuclear nodules, whereas P. wiackowskii is characterized by having a marinum-like oral apparatus and a long, sausage-shaped macronucleus.
Field development of physalis species produced in different shading levels

The objective of this work was to verify the fixation and development in the field and later production of Physalis seedlings species produced in different levels of shading. The treatments were composed by Physalis seedlings formed in different environment with shading and four species. The conduction system adopted was “V”. The seedlings survival rate, number of internodes, flowers number, number of fruit per plant, average fruit biomass per plant, yield and titratable acidity of fruits were evaluated. At the end of the production period, the stem diameter was evaluated. The experimental design was a randomized blocks, 4 x 4 factorial scheme (cultivation environments x species), with four replications. Seedlings produced in an environment of 25% were the ones that presented the highest survival rate when transplanting the field, favoring a greater glue of the seedlings. It was observed an increase of the fruits fresh biomass and the biomass of fruit per plant, and a higher number of fruit per plant in an environment with 25% of shading, and consequently the environment that had the highest fruit yield.
The effect of species composition dissimilarity on plant–herbivore network structure is not consistent over time

The structural organization of several antagonistic networks has been demonstrated to be largely conserved through time and space even when species beta‐diversity is high. This might occur either because species are replaced by others that fulfill similar network roles or because interaction probabilities are given by species relative abundances rather than by their functional traits. Alternatively, if species‐specific traits are important drivers of realized interactions, any change in species composition should promote a certain degree of network structural dissimilarity. Here, we used a spatial‐temporal system comprising asteraceous plants and flower head herbivores from remnants of Brazilian Cerrado to investigate whether the relationship between spatial beta‐diversity of species and network structural dissimilarity changes over time. We measured species beta‐diversity using Sørensen's dissimilarity index (βsor) and its components of species replacement (β‐3) and richness differences (βrich). Network structural dissimilarity was estimated using three different metrics: connectance, modularity, and web asymmetry. We show that, in general, the effect of species beta‐diversity on network structure was time‐dependent: While some periods presented a positive relationship between spatial beta‐diversity and network structural dissimilarity, others presented no significant relationship. This indicates that functionally similar species may present different turnover rates at distinct periods, and different non‐exclusive processes affect plant–herbivore network organization across time.
Localisation and expression of zeaxanthin epoxidase mRNA in Arabidopsis in response to drought stress and during seed development

Abscisic acid (ABA) is involved in seed development and plant adaptation to environmental stresses. ABA is synthesized from cleaved xanthophylls and zeaxanthin epoxidase (ZEP) is the enzyme responsible for the conversion of zeaxanthin to violaxanthin. In this study, we have characterized the ABA1 gene (AtZEP) of Arabidopsis thaliana L. and show that this complements the aba1 mutant, defective in zeaxanthin epoxidation. The molecular basis for two aba1 mutant alleles has been determined and the reduction in their AtZEP transcript levels correlates with the molecular defect identified. As AtZEP mRNA abundance was not affected in two other ABA-deficient mutants (aba2 and aba3) and in two ABA-insensitive mutants (abi1 and abi2), no feedback regulation of ABA biosynthesis seems to occur at the level of ZEP transcription. Steady state transcript levels increased in roots during rapid water stress as well as progressive drought stress, providing evidence that zeaxanthin epoxidation contributed to the regulation of ABA biosynthesis in roots and consequently to the plant adaptive response to hydric stress. In seeds in situ hybridization analysis detected AtZEP mRNA in the embryo cells from the globular stage to desiccation phase. In contrast, expression of AtZEP in maternal tissues was specific to the maturation phase. These results are discussed in relation to the role of ABA both in response to drought stress and in seed development.
Modeling tourism and fear nexus in G4 countries

ABSTRACT In this paper, we examine whether there is a causal relationship between migration-related fear and tourism. To achieve the objective, a lag-augmented vector autoregressive (LA-VAR) model that generates country-specific causality test results is employed. The period covered extends from 1995Q1 to 2016Q4. To control for omitted variable bias, we include real gross domestic product per capita as an additional variable. Empirical results provide evidence of one-way causality running from migration-related fear to tourism, and neutrality hypothesis is confirmed in the relationship between migration-related fear and economic growth, and between tourism and economic growth. Although the study confirms the fear-induced tourism hypothesis, it however further submits that other determinants such as exchange rates and real gross domestic product are much more important than fear in determining the number of arrivals at a destination.