Miracle-dz/UniFAR-FTUs huggingface dataset:
Risk of Coronary Artery Disease Associated With Polymorphism of the Cytochrome P450 Epoxygenase CYP2J2

Background—Cytochrome P450 (CYP) 2J2 is expressed in the vascular endothelium and metabolizes arachidonic acid to biologically active epoxyeicosatrienoic acids (EETs). The EETs are potent endogenous vasodilators and inhibitors of vascular inflammation. However, it is not known whether genetic polymorphisms of CYP2J2 are associated with increased cardiovascular risks. Methods and Results—All 9 exons of the CYP2J2 gene and its proximal promoter were sequenced in 132 patients to identify potential variants. Functional consequence of a single nucleotide polymorphism (SNP) in the promoter of CYP2J2 was further evaluated by use of transcription factor-binding and reporter assays. A total of 17 polymorphisms were identified. One of the most relevant polymorphisms in terms of frequency and functional importance is located at −50 (G-50T) in the proximal promoter of CYP2J2. Screening of 289 patients with coronary artery disease and 255 control subjects revealed 77 individuals with the G-50T SNP (17.3% of coronary artery disease patients, 10.6% of control subjects; P=0.026). The association of the G-50T polymorphism remained significant after adjustment for age, gender, and conventional cardiovascular risk factors (OR, 2.23; 95% CI, 1.04 to 4.79). The G-50T mutation resulted in the loss of binding of the Sp1 transcription factor to the CYP2J2 promoter and resulted in a 48.1±2.4% decrease in CYP2J2 promoter activity (P<0.01). Plasma concentrations of stable EET metabolites were significantly lower in individuals with the G-50T SNP. Conclusions—A functionally relevant polymorphism of the CYP2J2 gene is independently associated with an increased risk of coronary artery disease.
Congenital Retinal Fold, in Association with Pseudopapillitis

Iridoschisis. -P. McG. MOFFATT, F.R. C.S. W. H. , male, aged 59. No relevant previous history except that he did a lot of boxing during first World War and received several blows on and about the eyes and after one particularly severe blow in 1916, he states that the appearance of the right eye was altered but he still retained useful vision. No relevant family history. First attended Royal Westminster Hospital in 1943 for asthenopia and a disturbance of the pigment of the right eye was noted. Corrected vision was 6/6 R.E. , 6/9 L.E. The left eye showed early lens changes. Attended 1948 with mature cataract of left eye and post-central opacities of the right eye. The left lens was removed in 1948. In January 1949 the right cataract was mature and the left had 6/6 vision after capsulotomy. At this time fibres from the periphery of the iris were seen to be adherent to the posterior surface of the cornea in both eyes. He has now been admitted for right extraction and the condition was found to have progressed to its present state, which is shown in the photographs.
Minuet: Rethinking Concurrency Control in Storage Area Networks

Clustered applications in storage area networks (SANs), widely adopted in enterprise datacenters, have traditionally relied on distributed locking protocols to coordinate concurrent access to shared storage devices. We examine the semantics of traditional lock services for SAN environments and ask whether they are sufficient to guarantee data safety at the application level. We argue that a traditional lock service design that enforces strict mutual exclusion via a globally-consistent view of locking state is neither sufficient nor strictly necessary to ensure application-level correctness in the presence of asynchrony and failures. We also argue that in many cases, strongly-consistent locking imposes an additional and unnecessary constraint on application availability. Armed with these observations, we develop a set of novel concurrency control and recovery protocols for clustered SAN applications that achieve safety and liveness in the face of arbitrary asynchrony, crash failures, and network partitions. Finally, we present and evaluate Minuet- a new synchronization primitive based on these protocols that can serve as a foundational building block for safe and highly-available SAN applications.
Categorizing Children: Automated Text Classification of CHILDES files

In this paper we present the application of machine learning text classification methods to two tasks: categorization of children’s speech in the CHILDES Database according to gender and age. Both tasks are binary. For age, we distinguish two age groups between the age of 1.9 and 3.0 years old. The boundary between the groups lies at the age of 2.4 which is both the mean and the median of the age in our data set. We show that the machine learning approach, based on a bag of words, can achieve much better results than features such as average utterance length or Type-Token Ratio, which are methods traditionally used by linguists. We have achieved 80.5% and 70.5% classification accuracy for the age and gender task respectively.
Mutation of the Diamond-Blackfan Anemia Gene Rps7 in Mouse Results in Morphological and Neuroanatomical Phenotypes

The ribosome is an evolutionarily conserved organelle essential for cellular function. Ribosome construction requires assembly of approximately 80 different ribosomal proteins (RPs) and four different species of rRNA. As RPs co-assemble into one multi-subunit complex, mutation of the genes that encode RPs might be expected to give rise to phenocopies, in which the same phenotype is associated with loss-of-function of each individual gene. However, a more complex picture is emerging in which, in addition to a group of shared phenotypes, diverse RP gene-specific phenotypes are observed. Here we report the first two mouse mutations (Rps7Mtu and Rps7Zma) of ribosomal protein S7 (Rps7), a gene that has been implicated in Diamond-Blackfan anemia. Rps7 disruption results in decreased body size, abnormal skeletal morphology, mid-ventral white spotting, and eye malformations. These phenotypes are reported in other murine RP mutants and, as demonstrated for some other RP mutations, are ameliorated by Trp53 deficiency. Interestingly, Rps7 mutants have additional overt malformations of the developing central nervous system and deficits in working memory, phenotypes that are not reported in murine or human RP gene mutants. Conversely, Rps7 mouse mutants show no anemia or hyperpigmentation, phenotypes associated with mutation of human RPS7 and other murine RPs, respectively. We provide two novel RP mouse models and expand the repertoire of potential phenotypes that should be examined in RP mutants to further explore the concept of RP gene-specific phenotypes.
CHARTING A STRATEGIC MODEL FOR POST-COVID-19 TOURISM DESTINATION DEVELOPMENT: INSIGHTS FROM RIAU ISLANDS' TOP FOREIGN-TOURIST CITIES, INDONESIA

Purpose: The purpose of the research is to evaluate the impact of the COVID-19 pandemic on the tourism industry in the Riau Islands Province, Indonesia, and to reformulate a strategic model for developing tourist destinations, focusing on Batam City and Bintan Island. Theoretical framework: This study examines the impact of the COVID-19 pandemic on the Riau Islands, Indonesia, focusing on revitalizing the tourism sector. It aims to formulate a strategic model for tourism development by considering market analysis, infrastructure, and government policies to attract more foreign tourists and boost post-pandemic economic recovery. Design/methodology/approach: This study utilized a Mixed-Methods approach, Concurrent Triangulation Design, and the IFAS EFAS analysis. Data collection methods included questionnaires, interviews, focus group discussions, and observations. Quantitative data analysis involved percentage techniques, while qualitative data analysis followed Miles and Huberman's approach. Findings: This study identified Asian tourists as the most promising market for tourism in the Riau Islands Province, then highlighted the need for infrastructure improvement, enhancements in government policies to support tourism development, and the formulation of an aggressive growth-focused strategic model. Research, Practical & Social implications: The research compared Batam City and Bintan Island to develop post-COVID-19 tourism strategies, offering practical insights for policymakers to guide sustainable tourism development, benefiting local communities economically and socially by identifying key market opportunities and strategic directions. Originality/value: The study enhances existing literature by exploring challenges and opportunities in the tourism industry post-COVID-19 and offers a unique methodological approach, combining quantitative and qualitative methods to analyze the situation comprehensively.
Brownfield Redevelopment Evaluation Based on Fuzzy Real Options

There are a great amount of brownfield in Chinese mining cities. In order to promote mining cities sustainable development, it is necessary to redevelop brownfield. There is a great deal of uncertainty in the process of brownfield redevelopment owing to the influences of pollution. Normal fuzzy numbers were used to describe the fuzziness of the expected DCF (discounted cash flow) value of brownfield redevelopment projects. In view of experts’ preferences, the weight of fuzzed estimation intervals of the expected DCF value was determined by means of the lattice closeness degree to find the volatility of the expected DCF value. Combining the results with the B-S (Black-Scholes) real option model, we built a fuzzy real option model which could be applied to the brownfield redevelopment projects. The empirical results showed that the valuation results of the fuzzy real option model, considering the experts’ risk preferences, were relatively objective and accurate.
The GI–CDF module of Arabidopsis affects freezing tolerance and growth as well as flowering

Summary Plants monitor and integrate temperature, photoperiod and light quality signals to respond to continuous changes in their environment. The GIGANTEA (GI) protein is central in diverse signaling pathways, including photoperiodic, sugar and light signaling pathways, stress responses and circadian clock regulation. Previously, GI was shown to activate expression of the key floral regulators CONSTANS (CO) and FLOWERING LOCUS T (FT) by facilitating degradation of a family of CYCLING DOF FACTOR (CDF) transcriptional repressors. However, whether CDFs are implicated in other processes affected by GI remains unclear. We investigated the contribution of the GI–CDF module to traits that depend on GI. Transcriptome profiling indicated that mutations in GI and the CDF genes have antagonistic effects on expression of a wider set of genes than CO and FT, whilst other genes are regulated by GI independently of the CDFs. Detailed expression studies followed by phenotypic assays showed that the CDFs function downstream of GI, influencing responses to freezing temperatures and growth, but are not necessary for proper clock function. Thus GI‐mediated regulation of CDFs contributes to several processes in addition to flowering, but is not implicated in all of the traits influenced by GI.
Lessons from lensed Lyman break galaxies: can dusty Lyman break galaxies produce the submillimetre counts and background?

Can the submillimetre counts and background be produced by applying a locally derived extinction correction to the population of Lyman break galaxies? We investigate the submillimetre emission of two strongly lensed Lyman break galaxies (MS1512+36-cB58 and MS1358+62-G1) and find that the procedure that is used to predict the submillimetre emission of the Lyman break galaxy population overpredicts the observed 850 micron fluxes by a factor of up to 14. This result calls for caution in applying local correlations to distant galaxies. It also shows that large extinction corrections on Lyman break galaxies should be viewed with skepticism. It is concluded that the Lyman break galaxies may contribute to the submillimetre background at the 25 to 50% level. The brighter submillimetre galaxies making up the rest of the background are either not detected in optical surveys, or if they are detected, their submillimetre emission cannot be reliably estimated from their rest-frame ultraviolet properties.
A Systematic Review of School-Based Alcohol and other Drug Prevention Programs

Background: Alcohol use in adolescents constitutes a major public health concern. Europe is the heaviest drinking region of the world. Several school-based alcohol prevention programs have been developed but it is not clear whether they are really effective. The present study was aimed at identifying the typology with the best evidence of effectiveness in European studies. Methods: A systematic search of meta-analyses and/or randomized controlled trials (RCTs) on interventions school-based prevention programs aimed at preventing alcohol consumption or changing the attitudes to consume alcohol. Results: A meta-analysis published in 2011 and 12 RCTs more recently published were identified. The meta-analysis evaluated 53 RCTs but only 11.3% of them were conducted in Europe. Globally, 23 RCTs (43.4%) showed some evidence of effectiveness, and 30 RCTs (56.6%) did not find significant difference between the groups. According to the conclusions of the meta-analysis, the Unplugged program should be considered as a practice option in Europe. Among the other 12 RCTs, 42% were conducted in Europe. Globally, 7 studies (58.3%) achieved positive results, and 5 studies (41.7%) did not find significant differences or produced a mixed pattern of results. Three of the 5 European trials (60%) used the Unplugged program with positive results. Conclusion: Even if further studies should be conducted to confirm these results, Unplugged appears to be the prevention project with the best evidence of effectiveness in European studies.
Transcriptional and Functional Adaptations of Human Endothelial Cells to Physiological Chronic Low Oxygen1

ABSTRACT Endothelial cells chronically reside in low-O2 environments in vivo (2%–13% O2), which are believed to be critical for cell homeostasis. To elucidate the roles of this physiological chronic normoxia in human endothelial cells, we examined transcriptomes of human umbilical vein endothelial cells (HUVECs), proliferation and migration of HUVECs in response to fibroblast growth factor 2 (FGF2) and vascular endothelial growth factor A (VEGFA), and underlying signaling mechanisms under physiological chronic normoxia. Immediately after isolation, HUVECs were cultured steadily under standard cell culture normoxia (SCN; 21% O2) or physiological chronic normoxia (PCN; 3% O2) up to 25 days. We found that PCN up-regulated 41 genes and down-regulated 21 genes, 90% of which differed from those previously reported from HUVECs cultured under SCN and exposed to acute low O2. Gene ontology analysis indicated that PCN-regulated genes were highly related to cell proliferation and migration, consistent with the results from benchtop assays that showed that PCN significantly enhanced FGF2- and VEGFA-stimulated cell proliferation and migration. Interestingly, preexposing the PCN cells to 21% O2 up to 5 days did not completely diminish PCN-enhanced cell proliferation and migration. These PCN-enhanced cell proliferations and migrations were mediated via augmented activation of MEK1/MEK2/ERK1/ERK2 and/or PI3K/AKT1. Importantly, these PCN-enhanced cellular responses were associated with an increase in activation of VEGFR2 but not FGFR1, without altering their expression. Thus, PCN programs endothelial cells to undergo dramatic changes in transcriptomes and sensitizes cellular proliferative and migratory responses to FGF2 and VEGFA. These PCN cells may offer a unique endothelial model, more closely mimicking the in vivo states.
Managing Long-Lived COTS Based Systems

Managing long-lived computer systems containing a large number of Commercial Off-The-Shelf (COTS) software components requires a significant investment of effort. This effort is spent on a number of activities, including adding, replacing and deleting components, integrating and customizing components, and monitoring and troubleshooting the system. Organizations can reduce the time and cost required for these system management activities and increase the usability and reliability of a system, by planning for system management during acquisition. This paper describes how organizations can use software architecture, software instrumentation, and component-based configuration management to support the ongoing system management activities.
Bim 1 p / Yeb 1 p Mediates the Kar 9 p-dependent Cortical Attachment of Cytoplasmic Microtubules

In Saccharomyces cerevisiae, positioning of the mitotic spindle depends on the interaction of cytoplasmic microtubules with the cell cortex. In this process, cortical Kar9p in the bud acts as a link between the actin and microtubule cytoskeletons. To identify Kar9p-interacting proteins, a two-hybrid screen was conducted with the use of full-length Kar9p as bait, and three genes were identified: BIM1, STU2, and KAR9 itself. STU2 encodes a component of the spindle pole body. Bim1p is the yeast homologue of the human microtubule-binding protein EB1, which is a binding partner to the adenomatous polyposis coli protein involved in colon cancer. Eighty-nine amino acids within the third quarter of Bim1p was sufficient to confer interaction with Kar9p. The two-hybrid interactions were confirmed with the use of coimmunoprecipitation experiments. Genetic analysis placed Bim1p in the Kar9p pathway for nuclear migration. Bim1p was not required for Kar9p’s cortical or spindle pole body localization. However, deletion of BIM1 eliminated Kar9p localization along cytoplasmic microtubules. Furthermore, in the bim1 mutants, the cytoplasmic microtubules no longer intersected the cortical dot of Green Fluorescent Protein– Kar9p. These experiments demonstrate that the interaction of cytoplasmic microtubules with the Kar9p cortical attachment site requires the microtubule-binding protein Bim1p.
Pleistocene deep-sea ostracods from the Oki Ridge, Sea of Japan (IODP Site U1426) and condition of the intermediate water

Abstract The Sea of Japan (also termed the East Sea) has a circulation system isolated from the Pacific Ocean and East China Sea. The East Asian winter monsoon drives the circulation system and cools the Tsushima Warm Current (TWC) to form the Japan Sea Intermediate–Proper Water (JSIPW). The intermediate water conveys oxygen to deep-sea floors, which is available for benthic animals. During the Pliocene (3.5–2.8 Ma), Temperate Intermediate Water (TIW) was formed under the weak winter monsoon, and extinct ostracod TIW taxa were found. Little is known about early Pleistocene intermediate water and the extinction mode of benthic ostracods. We studied radiolarians and ostracods from deep-sea sediments between 2.0 and 1.3 Ma (Marine Oxygen Isotope Stage [MIS] 77 to MIS 41) at Integrated Ocean Drilling Program Site U1426, Sea of Japan. The ostracod faunas contained TIW and JSIPW taxa. The radiolarian subtropical-water taxa and the JSIPW ostracods indicate a small influx of the TWC and the JSIPW. The TIW occasionally expanded to the middle bathyal zone. By analogy with the relationship between the modern JSIPW and winter monsoon, weak winter monsoon possibly caused gentle temperature gradients in the water column and the expansion of the TIW. The JSIPW taxa expanded their ranges into the deep sea during interglacial periods.
AERONET Remotely Sensed Measurements and Retrievals of Biomass Burning Aerosol Optical Properties During the 2015 Indonesian Burning Season

An extreme biomass burning event occurred in Indonesia from September through October 2015 due to severe drought conditions, partially caused by a major El Niño event, thereby allowing for significant burning of peatland that had been previously drained. This event had the highest sustained aerosol optical depths (AODs) ever monitored by the global Aerosol Robotic Network (AERONET). The newly developed AERONET Version 3 algorithms retain high AOD at the longer wavelengths when associated with high Ångström exponents (AEs), which thereby allowed for measurements of AOD at 675 nm as high as approximately 7, the upper limit of Sun photometry. Measured AEs at the highest monitored AOD levels were subsequently utilized to estimate instantaneous values of AOD at 550 nm in the range of 11 to 13, well beyond the upper measurement limit. Additionally, retrievals of complex refractive indices, size distributions, and single scattering albedos (SSAs) were obtained at much higher AOD levels than possible from almucantar scans due to the ability to perform retrievals at smaller solar zenith angles with new hybrid sky radiance scans. For retrievals made at the highest AOD levels the fine‐mode volume median radii were ~0.25–0.30 micron, which are very large particles for biomass burning. Very high SSA values (~0.975 from 440 to 1,020 nm) are consistent with the domination by smoldering combustion of peat burning. Estimates of the percentage peat contribution to total biomass burning aerosol based on retrieved SSA and laboratory measured peat SSA were ~80–85%, in excellent agreement with independent estimates.
The Empirical Relationship between Average Asset Correlation, Firm Probability of Default and Asset Size

The asymptotic single risk factor (ASRF) approach is a simplified framework for determining regulatory capital charges for credit risk and has become an integral part of how credit risk capital requirements are to be determined under the second Basel Accord. Within this approach, a key regulatory parameter is the average asset correlation. In this paper, we examine the empirical relationship between the average asset correlation, firm probability of default and firm asset size measured by the book value of assets by imposing the ASRF approach within the KMV methodology for determining credit risk capital requirements. Using data from year-end 2000, credit portfolios consisting of U.S., Japanese and European firms are analyzed. The empirical results suggest that average asset correlation is a decreasing function of probability of default and an increasing function of asset size. When compared with the average asset correlations proposed by the Basel Committee on Banking Supervision in November 2001, the empirical average asset correlations further suggest that accounting for firm asset size, especially for larger firms, may be important. In conclusion, the empirical results suggest that a variety of factors may impact average asset correlations within an ASRF framework, and these factors may need to be accounted for in the final calculation of regulatory capital requirements for credit risk.
Acceptability Assessment of Ugali Made from Blends of High Quality Cassava Flour and Cereal Flours in the Lake Zone, Tanzania

Cassava is the most known hunger fighter crop in sub-Saharan African countries during drought and severe famine, its production has been limited to household’s consumption and not to commercialization. The aim of this study was to assess consumer acceptability and willingness to pay for blends of high quality cassava flour (HQCF) and refined maize ( sembe ) or unrefined maize ( dona ) or sorghum in Lake Zone. The HQCF was mixed with either sembe flour (20:80) or dona flour (80:20) or sorghum flour (80:20) separately. Ugali made at these ratios of the blends were fed to 129 people (Mwanza n = 60 and Bunda n = 69) and descriptively evaluated sensory properties. It was found that 65.9% of the consumers preferred ugali made from blends of HQCF. About 51.2% consumer preferred ugali made from blends of HQCF and Sorghum flour and for blends of HQCF and dona at (80:20). Consumers willing to pay price between TZS 1000/kg and TZS1500/kg for blends of HQCF: sembe was 62%, HQCF: sorghum was 61% and HQCF: dona was 46%. Marketing expansion opportunities for blends of HQCF and cereal flours are high suggesting the needs for interventions at production, processing and supply to the market.