Miracle-dz/UniFAR-FTUs huggingface dataset:
Analyzing and Forecasting Lightning Flashes and the Related Wind Gusts at a Wind Energy Power Plant in a Hilly Region of Western Greece

Wind energy power plants are vulnerable, among others, to abrupt weather changes caused especially by thunderstorms associated with lightning activity and the accompanying severe wind gusts and rapid wind direction changes. Due to a range of damages such phenomena may cause, the knowledge of the relationship between the storm systems and the produced wind field is essential to establish a wind power plant during the construction and operation phase as well. In first part of this study, the relationship of severe wind gusts in regard to lightning activity in a wind farm in a hilly region of western Greece is investigated. Wind data come from wind turbines covering a period of three years (2012-2014), while the corresponding lightning data from the ZEUS lighting detection network. The analysis shows that wind gusts are well correlated to lightning strikes. Furthermore, correlation maximizes during winter when well organized weather systems affect the area and minimum in summer as a result of local storms due to thermal instability. In the second part the study focuses on the development of an ANN model in order to forecast these two parameters in a horizon of 1-h ahead by using except for the wind data, four variables namely CAPE, TTI, wind speed at the 500 hPa isobaric level and the 0-6 km vertical wind shear. The results revealed that proposed model could be considered as a promising tool in simulating the occurrence both of wind gusts and lightning flashes providing a relatively good evidence of the possibility of occurrence of such events.
Regional spillovers of knowledge in Brazil: evidence from science and technology municipal indicators

ABSTRACT This paper evaluates the role of regional spillovers of knowledge in Brazilian municipalities. The main hypothesis here is that regional inequalities restrict the knowledge spillovers in developing economies. We use a random-effects spatial panel model with data for two years, 2010 and 2015. Estimations indicate that regional spillovers of knowledge are important for innovation in Brazilian municipalities. The local scientific structure and economic specialization are also relevant for municipal innovativeness. The findings herein also provide evidence suggesting that spillovers are spatially restricted and will tend to reinforce the long-term regional imbalances in the Brazilian innovation system in the foreseeable future.
EFFECT OF MOISTURE ON NITROGEN DIOXIDE FORMATION IN LAMINAR FLAME OF NATURAL GAS

The paper contains the results of experimental studies of the effect of moisture on nitrogen dioxide formation and on oxidation of NO to NO2 in laminar premixed flame of natural gas. The water vapor is shown to be the third very influential participant, along with fuel and oxidizer, in the combustion process. Injection of moisture into the combustion zone has an effect due to the insertion of additional quantities of HO2- and OH– radicals into the process, which contributes to the intensification of the oxidation of NO to NO2. Introduction of the concept of the “excess moisture ratio” in the combustion process is proposed. The studies were executed at the laboratory installation in conditions of formation of the V-shaped laminar flame of natural gas behind a transverse cylindrical steel stabilizer, with determining the concentrations of flue gas components.
Analysis of Work Posture with Complaints of Musculoskeletal Disorder on Stack Emission Sampling Activities

Objective and Background: The process of sampling the air quality of chimney emissions is a job that has the risk of causing work-related disorders and diseases. This study examines the relationship between the risk of ergonomics in work postures with material safety data sheet complaints on sampling activities. Methods: Analytical observational method with cross sectional approach. using the Nordic Body Map questionnaire and the Rapid Entire Body Assessment (REBA) assessment sheet. Primary data and secondary data were analyzed using Rank Spearman statistical test. Results: The level of risk of ergonomics in work postures at each stage of activity varies from low risk (value 2-3), medium (value is 4-7), and high (value 8 -10). Meanwhile, the level of MSDscomplaints was low (score 28-49) 11.1%, moderate complaints (score 50-70) were 44.4% and high complaints (score 71-91) were 44.4%. The results of the analysis test showed that there was a relationship between the level of ergonomics risk of working postures at 6 stages of activity, namely pre sampling, side preparation, climbing stairs, raising equipment, lowering equipment, and descending stairs (p-value < 0.05). Conclusion: Based on the other 4 stages of activity, namely sampling with a probe, sampling with a gas analyzer, measuring water content, and measuring particulate levels, there is no relationship between the level of ergonomics in work posture and complaints of MSDs, to reduce the risk of M.S.D.s complaints, efforts can be made through redesigning work stations that are not ergonomic with the use of tools to reduce workload.
Feasibility and efficacy of transthoracic single-port assisted laparoscopic esophagogastrectomy for Siewert type II adenocarcinoma of the esophagogastric junction

Background The surgical treatment of Siewert type II adenocarcinoma of the esophagogastric junction (AEG) is controversial, and no systematic technology has been established. The aim of this retrospective study is to introduce the technology of transthoracic single-port assisted laparoscopic esophagogastrectomy. Methods Data from patients with Siewert type II AEG who underwent transthoracic single-port assisted laparoscopic esophagogastrectomy in Guangdong Provincial Hospital of Chinese Medicine from May 2017 to December 2020 were analyzed. Results A total of 35 patients, including 30 males and 5 females, were enrolled in this study. Eight patients underwent proximal gastrectomy while the other 27 patients underwent total gastrectomy. The median operative times were 247.5 (195.0–275.0) min and 290.0 (173.0–530.0) min for proximal and total gastrectomy, respectively. The median lower mediastinal lymph node dissection (LMLD) time was 41.5 (20.0–57.0) min and the median estimated blood loss was 100.0 (20.0–200.0) mL. The median number of harvested mediastinal lymph nodes was 5 [2–13]. Lower mediastinal lymph node metastasis occurred in 9 patients (25.7%). The lower mediastinal lymph node metastasis rate was significantly higher in patients with esophageal involvement exceeding 2 cm [>2 vs. ≤2 cm: 55.6% (5/9) vs. 15.4% (4/26), P=0.03]. The median postoperative hospital stay was 10 [6–73] days. Overall morbidity was 11.8% (4 patients), including 2 cases of pleural effusion, 1 case of pancreatic fistula, and 1 case of anastomotic leakage. Conclusions Transthoracic single-port assisted laparoscopic esophagogastrectomy is safe and feasible. It has the advantages of reducing the difficulty of LMLD and digestive tract reconstruction.
A Link between Chronic Kidney Disease and Gut Microbiota in Immunological and Nutritional Aspects

Chronic kidney disease (CKD) is generally progressive and irreversible, structural or functional renal impairment for 3 or more months affecting multiple metabolic pathways. Recently, the composition, dynamics, and stability of a patient’s microbiota has been noted to play a significant role during disease onset or progression. Increasing urea concentration during CKD can lead to an acceleration of the process of kidney injury leading to alterations in the intestinal microbiota that can increase the production of gut-derived toxins and alter the intestinal epithelial barrier. A detailed analysis of the relationship between the role of intestinal microbiota and the development of inflammation within the symbiotic and dysbiotic intestinal microbiota showed significant changes in kidney dysfunction. Several recent studies have determined that dietary factors can significantly influence the activation of immune cells and their mediators. Moreover, dietary changes can profoundly affect the balance of gut microbiota. The aim of this review is to present the importance and factors influencing the differentiation of the human microbiota in the progression of kidney diseases, such as CKD, IgA nephropathy, idiopatic nephropathy, and diabetic kidney disease, with particular emphasis on the role of the immune system. Moreover, the effects of nutrients, bioactive compounds on the immune system in development of chronic kidney disease were reviewed.
Crystal structure and vibrational spectra of bis(2-isobutyrylamidophenyl)amine: a redox noninnocent ligand

The molecular structure of bis(2-isobutyrylamidophenyl)amine (H3LNNN) has been determined from single-crystal X-ray diffraction data. The crystal packing of H3LNNN is governed by the N–H···O and C–H···O hydrogen-bonding and C–H···π stacking interactions between the vicinal molecules. The intermolecular interactions in the crystal structure of H3LNNN have been also examined via Hirshfeld surface analysis and fingerprint plots. The Hirshfeld surface analysis showed that the important role of N–H···O and C–H···π interactions in the solid-state structure of H3LNNN. The molecular structure, vibrational frequencies, and infrared intensities of H3LNNN were computed by ab initio HF and DFT (B3LYP, B3PW91, and BLYP) methods using the 6–31G(d,p) basis set. The computed theoretical geometric parameters were compared with the corresponding single crystal structure of H3LNNN. The harmonic vibrations calculated for the title compound by the B3LYP method are in good agreement with the experimental IR spectral data. The theoretical vibrational spectrum of the H3LNNN compound was interpreted through potential energy distributions using the SQM Version 2.0 program. The performance of the used methods and the scaling factor values were calculated with PAVF Version 1.0 program.
Left Atrial Remodeling after Mitral Valve Repair for Primary Mitral Regurgitation: Evolution over Time and Prognostic Significance

Left atrial (LA) dilatation is associated with worse outcomes in primary mitral regurgitation (MR). However, the effects of mitral valve repair on LA size and its prognostic implications are not well known. In the current study, LA volume index (LAVi) and LA reservoir strain (LASr) were evaluated immediately before and after surgery, and during long-term follow-up in 226 patients undergoing mitral valve repair for primary MR (age 62 ± 13 years, 66% male). Mean LAVi was reduced significantly after surgery and at long-term follow-up (from 56 ± 28 to 38 ± 21 to 32 ± 17 mL/m2; p < 0.001). LASr reduced significantly after surgery but increased again during the long-term (from 23.6 ± 9.4 to 11.5 ± 5.0 to 17.3 ± 7.5%; p < 0.001). Age, pre-operative LAVi, MR severity, and postoperative transmitral pressure gradient were associated with LA reverse remodeling by the long-term check-up. During a median follow-up of 72 (40–114) months, 43 (19%) patients died. Patients with LAVi ≥ 42 mL/m2 at long-term follow-up showed significant higher mortality rates compared to patients with LAVI < 42 mL/m2 (p < 0.001), even after adjusting for clinical covariates. In conclusion, significant LA reverse remodeling was observed both immediately and at long-term follow-up after mitral valve repair. LA dilatation at long term follow-up after surgery was still associated with all-cause mortality.
Evaluation of the Effect of Different Concentrations of Spirotetramat on the Diaspine Scale Parlatoria ziziphi in Citrus Orchards

The control of Parlatoria ziziphi (Lucas, 1853) was studied in citrus orchards at Mechraa Belksiri in the Gharb area of Morocco. Three concentrations of spirotetramat T0 = 0 L/Ha as a control experiment, T1 = 0.625 L/Ha, T2 = 0.755 L/Ha, and T3 = 1 L/Ha, were applied on 4 ha of Valencia late orchard (each dose for 1 ha of Valencia late). The effect of spirotetramat was evaluated on the mortalities and survival rates of P. ziziphin during the stages of larvae (first instar and second instar) and females (F1, F2, and F3). Results showed that the spirotetramat was effective on larvae and females of P. ziziphi. Among the 11,229 females recorded, 93% were inhibited, while only 7% were intact after the treatment period. Finally, our study highlights that all concentrations tested were effective on the P. ziziphi population; besides, all three concentrations of this product tested were equally effective on larvae and females of P. ziziphi. Thus, during the spread period, spraying a low concentration of this product (0.625 L/Ha) will better control this pest and reduce the environmental impact.
From Bench to Field: A Guide to Formulating and Evaluating Anti-Tick Vaccines Delving beyond Efficacy to Effectiveness

Ticks are ubiquitous blood-sucking ectoparasites capable of transmitting a wide range of pathogens such as bacteria, viruses, protozoa, and fungi to animals and humans. Although the use of chemicals (acaricides) is the predominant method of tick-control, there are increasing incidents of acaricide tick resistance. Furthermore, there are concerns over accumulation of acaricide residues in meat, milk and in the environment. Therefore, alternative methods of tick-control have been proposed, of which anti-tick cattle vaccination is regarded as sustainable and user-friendly. Over the years, tremendous progress has been made in identifying and evaluating novel candidate tick vaccines, yet none of them have reached the global market. Until now, Bm86-based vaccines (Gavac™ in Cuba and TickGARDPLUS™ Australia-ceased in 2010) are still the only globally commercialized anti-tick vaccines. In contrast to Bm86, often, the novel candidate anti-tick vaccines show a lower protection efficacy. Why is this so? In response, herein, the potential bottlenecks to formulating efficacious anti-tick vaccines are examined. Aside from Bm86, the effectiveness of other anti-tick vaccines is rarely assessed. So, how can the researchers assess anti-tick vaccine effectiveness before field application? The approaches that are currently used to determine anti-tick vaccine efficacy are re-examined in this review. In addition, a model is proposed to aid in assessing anti-tick vaccine effectiveness. Finally, based on the principles for the development of general veterinary vaccines, a pipeline is proposed to guide in the development of anti-tick vaccines.
Consumers Acceptance and Intention to Forward EWOM Messages: The Influences of Volume, Valence, Content Quality, Source Credibility and Homophily

The emergence of online communities and social media has gradually transformed the way society works. It has motivated people to generate and spread electronic word of mouth (EWOM) intentionally and unintentionally. Today, people and consumers move from passive information receivers to more active experiencers. This research aims at understanding the nature of customer acceptance, intention to forward EWOM messages, and the impacts of volume, valence, source credibility, and homophily on these mentioned behaviors. An online structured questionnaire and PLS-SEM statistical technique were used to test. The results from the data analysis of 367 respondents showed significance and positivity in all examined relationships. The acceptance of the EWOM message has a substantial impact on the intention to forward it. The EWOM acceptance was influenced by all proposed independent factors, whereas the forwarding intention was determined by three factors of source credibility, homophily, and acceptance of EWOM.
Molecular Characterization and Taxonomic Assignment of Three Phage Isolates from a Collection Infecting Pseudomonas syringae pv. actinidiae and P. syringae pv. phaseolicola from Northern Italy

Bacterial kiwifruit vine disease (Pseudomonas syringae pv. actinidiae, Psa) and halo blight of bean (P. syringae pv. phaseolicola, Pph) are routinely treated with copper, leading to environmental pollution and bacterial copper resistance. An alternative sustainable control method could be based on bacteriophages, as phage biocontrol offers high specificity and does not result in the spread of toxic residues into the environment or the food chain. In this research, specific phages suitable for phage-based biocontrol strategies effective against Psa and Pph were isolated and characterized. In total, sixteen lytic Pph phage isolates and seven lytic Psa phage isolates were isolated from soil in Piedmont and Veneto in northern Italy. Genome characterization of fifteen selected phages revealed that the isolated Pph phages were highly similar and could be considered as isolates of a novel species, whereas the isolated Psa phages grouped into four distinct clades, two of which represent putative novel species. No lysogeny-, virulence- or toxin-related genes were found in four phages, making them suitable for potential biocontrol purposes. A partial biological characterization including a host range analysis was performed on a representative subset of these isolates. This analysis was a prerequisite to assess their efficacy in greenhouse and in field trials, using different delivery strategies.
Diploid genome assembly of Kluyveromyces marxianus NRRL Y-50883 (SLP1)

Abstract The yeast Kluyveromyces marxianus SLP1 has the potential for application in biotechnological processes because it can metabolize several sugars and produce high-value metabolites. K. marxianus SLP1 is a thermotolerant yeast isolated from the mezcal process, and it is tolerant to several cell growth inhibitors such as saponins, furan aldehydes, weak acids, and phenolics compounds. The genomic differences between dairy and nondairy strains related to K. marxianus variability are a focus of research attention, particularly the pathways leading this species toward polyploidy. We report the diploid genome assembly of K. marxianus SLP1 nonlactide strain into 32 contigs to reach a size of ∼12 Mb (N50 = 1.3 Mb) and a ∼39% GC content. Genome size is consistent with the k-mer frequency results. Genome annotation by Funannotate estimated 5000 genes in haplotype A and 4910 in haplotype B. The enriched annotated genes by ontology show differences between alleles in biological processes and cellular component. The analysis of variants related to DMKU3 and between haplotypes shows changes in LAC12 and INU1, which we hypothesize can impact carbon source performance. This report presents the first polyploid K. marxianus strain recovered from nonlactic fermenting medium.
Studies on Aggregated Nanoparticles Steering during Deep Brain Membrane Crossing

Many central nervous system (CNS) diseases, such as Alzheimer’s disease (AD), affect the deep brain region, which hinders their effective treatment. The hippocampus, a deep brain area critical for learning and memory, is especially vulnerable to damage during early stages of AD. Magnetic drug targeting has shown high potential in delivering drugs to a targeted disease site effectively by applying a strong electromagnetic force. This study illustrates a nanotechnology-based scheme for delivering magnetic nanoparticles (MNP) to the deep brain region. First, we developed a mathematical model and a molecular dynamic simulation to analyze membrane crossing, and to study the effects of particle size, aggregation, and crossing velocities. Then, using in vitro experiments, we studied effective parameters in aggregation. We have also studied the process and environmental parameters. We have demonstrated that aggregation size can be controlled when particles are subjected to external electromagnetic fields. Our simulations and experimental studies can be used for capturing MNPs in brain, the transport of particles across the intact BBB and deep region targeting. These results are in line with previous in vivo studies and establish an effective strategy for deep brain region targeting with drug loaded MNPs through the application of an external electromagnetic field.
Implications of Endothelial Cell-Mediated Dysfunctions in Vasomotor Tone Regulation

Cardiovascular diseases (CVD) constitute the major cause of death worldwide and show a higher prevalence in the adult population. The human umbilical cord consistsof two arteries and one vein, both composed of three tunics. The tunica intima, lined with endothelial cells, regulates vascular tone through the production/release of vasoregulatory substances. These substances can be vasoactive factors released by endothelial cells (ECs) that cause vasodilation (NO, PGI2, EDHF, and Bradykinin) or vasoconstriction (ET1, TXA2, and Ang II) depending on the cell type (ECs or SMC) that reacts to the stimulus. Vascular studies using ECs are important for the analysis of cardiovascular diseases since endothelial dysfunction is an important CVD risk factor. In this paper, we will address the morphological characteristics of the human umbilical cord and its component vessels. the constitution of the vascular endothelium, and the evolution of human umbilical cord-derived endothelial cells when isolated. Moreover, the role played by the endothelium in the vasomotor tone regulation, and how it may be associated with the existence of CVD, were discussed.
A Position-Aware Transformer for Image Captioning

: Image captioning aims to generate a corresponding description of an image. In recent years, neural encoder-decoder models have been the dominant approaches, in which the Convolutional Neural Network (CNN) and Long Short Term Memory (LSTM) are used to translate an image into a natural language description. Among these approaches, the visual attention mechanisms are widely used to enable deeper image understanding through fine-grained analysis and even multiple steps of reasoning. However, most conventional visual attention mechanisms are based on high-level image features, ignoring the effects of other image features, and giving insufficient consideration to the relative positions between image features. In this work, we propose a Position-Aware Transformer model with image-feature attention and position-aware attention mechanisms for the above problems. The image-feature attention firstly extracts multi-level features by using Feature Pyramid Network (FPN), then utilizes the scaled-dot-product to fuse these features, which enables our model to detect objects of different scales in the image more effectively without increasing parameters. In the position-aware attention mechanism, the relative positions between image features are obtained at first, afterwards the relative positions are incorporated into the originalimage features to generate captions more accurately. Experiments are carried out on the MSCOCO dataset and our approach achieves competitive BLEU-4, METEOR, ROUGE-L, CIDEr scores compared with some state-of-the-art approaches, demonstrating the effectiveness of our approach.