Miracle-dz/UniFAR-FTUs huggingface dataset:
Relaxation dynamics of a free elongated liquid ligament

The time-dependent relaxation dynamics of a moderately elongated liquid ligament in air have been numerically studied. The Navier-Stokes equations are solved using a finite-volume formulation with a two-step projection method on a fixed grid. The free surface of the liquid ligament is tracked by a coupled level set and volume-of-fluid method with the surface tension force determined by the continuum surface force model. The relaxation process of the elongated liquid ligament has been simulated and the end-pinching mechanism of the breakup process has been thoroughly examined. It has been found that the formation of a neck is not necessarily a precursor for breakup as inaccurately theorized in the end-pinching mechanism in the literature. The neck may reopen after undergoing an initial development towards pinch-off. In such an instance, droplet pinch-off will not occur. The determining factor for the reopening of a pinching neck has been identified. The experimentally observed restabilization phenomenon, in which further increase of the elongation ratio beyond the critical value would lead to cessation of pinch-off breakup, has also been investigated. Finally, the effects of several parameters on the relaxation mechanism have been examined. The initial end shape and length of the ligament and the Ohnesorge number have been found to play a vital role in the overall relaxation process.
Empirical Likelihood for a Heteroscedastic Partial Linear Errors-in-Variables Model

The purpose of this article is to use the empirical likelihood method to study construction of the confidence region for the parameter of interest in heteroscedastic partially linear errors-in-variables model with martingale difference errors. When the variance functions of the errors are known or unknown, we propose the empirical log-likelihood ratio statistics for the parameter of interest. For each case, a nonparametric version of Wilks’ theorem is derived. The results are then used to construct confidence regions of the parameter. A simulation study is carried out to assess the performance of the empirical likelihood method.
Transmissibility across simply supported thin plates. I. Rectangular and square plates with and without damping layers

The transmissibility across thin, simply supported, rectangular, and square aluminum plates has been determined experimentally and found to agree closely with theoretical prediction through the frequency range of measurement, which extended from 25 to 3025 Hz. Both the rectangular and the square plates considered were uniquely supported by spring‐steel flanges, which were designed to provide, for the first time, true simple supports that simulated almost identically the idealized supports assumed as boundary conditions in theoretical analyses for more than a century. For example, the first 20 resonant frequencies of the rectangular plate with these novel supports differed, with only one exception, by less than 0.55% from their predicted values. One important result obtained for the damped plates considered—which comprised aluminum plates plus applied tiles of high‐damping compound to yield composite plates having damping factors of essentially 0.3—was that the measured transmissibility across the plates c.
March 1987 cyclone (blizzard) over the eastern Mediterranean and Balkan region associated with blocking

Abstract The March 1987 blizzard over the eastern Mediterranean and Balkan regions is investigated. Northern Hemispheric and regional 250- and 850-hPa geopotential heights illustrate the formation of blocking over northern Europe and cyclogenesis over the considered area. The 850-hPa analyses and National Centers for Environmental Prediction Eta model simulations are in good agreement. Temporal analyses of temperature and precipitation fields show that a cold air surge over the region resulted in a decrease in the daily temperatures of up to 15°C and a heavy accumulation of snow in the early days of the storm. Spatial analyses of the precipitation field reveal that the most snowfall-affected regions were northwestern Turkey and the Balkan countries.
The Impact of COVID-19 Regulations on Adherence to Recombinant Human Growth Hormone Therapy: Evidence from Real-World Data

Worldwide regulations during COVID-19 positively and negatively impacted self-management in paediatric patients with chronic medical conditions. We investigated the impact of regulations on adherence to recombinant human growth hormone (r-hGH) therapy in paediatric patients with growth disorders, using real-world adherence data extracted March 2019–February 2020 (before COVID-19) and March 2020–February 2021 (during COVID-19) from the easypod™ connect ecosystem. Data from three measures of regulations were analysed: stringency index (SI), school closure and stay-at-home. The mean SI, and the proportion of days with required school closure or stay-at-home during COVID-19 were categorised as high versus medium/low based on the 75th percentile. Adherence was categorised as optimal (≥85%) versus suboptimal (<85%). Adherence data were available for 8915 patients before and 7606 patients during COVID-19. A high SI (mean ≥68) and a high proportion of required school closure (≥88%) resulted in an increase in the proportion of optimal adherence during COVID-19 versus pre-COVID-19 (p < 0.001). Stay-at-home requirements showed no statistically significant effect (p = 0.13). Stringent COVID-19 regulations resulted in improved adherence to r-hGH therapy in patients with growth disorders, supported by connected digital health technologies. Insights into patient behavior during this time are useful to understand potential influences and strategies to improve long-term adherence to r-hGH.
Intelligent Recommendation for Departments Based on Medical Knowledge Graph

The clinical sub-speciality departments are increasing. It is usually difficult for patients without medical education to choose a suitable department when they need to make an online registration with doctor. A novel approach is presented for departments recommendation in this paper. The ICD codes and symptoms of medical health data are used to describe the patients’ characteristics, diseases, and departments in the quantitative relation. The knowledge graph is built with the relations to automatically recommend departments. The MacBERT-BiLSTM-CRF medical entity recognition model (MacNER) is proposed to identify the patient’s symptoms, parts, treatment methods and drug entities to structure a knowledge graph. The knowledge graph is used to provide knowledge for the intelligent department recommendation. The identified entities are mapped to nodes in the graph with the entity mapping method. Finally, an algorithm named Feature Rate Multiply Converse Disease Rate (FRMCDR) is proposed. The most appropriate department can be recommended by fusing the patient’s chief complaint and past medical history. The experiment shows that our method obtained an 88.77% precision rate in the recommendation.
Diffusion in disordered fractals

Diffusion in disordered media can be modelled by the anomalous diffusion in fractals. Up to now, usually regular fractals were used as models for such disordered systems. Here we study disordered fractals in an attempt to capture the random nature of the disordered material. In particular, we investigate the diffusion in fractals obtained by randomly mixing different Sierpinski carpet generators. We find that the random-walk exponent dw shows strong dependance on the mixture composition. For the mixed system it can be higher or lower than both the pure components. Further, dw may decrease on mixing, indicating faster diffusion in the disordered system.
Metabolic Alterations in Multiple Myeloma: From Oncogenesis to Proteasome Inhibitor Resistance

Simple Summary Multiple myeloma (MM) is a common blood cancer that affects plasma cells, a type of immune cell found in bone marrow. Treatment options for MM have improved in recent years, but most patients eventually become resistant to existing therapies, highlighting the need for better treatments. MM cells alter their cellular metabolism to fuel growth and survival and can further adapt their metabolism to promote drug resistance. Here we review the metabolic changes that occur in MM and in the development of resistance to proteasome inhibitors, a common MM therapy, and discuss opportunities for therapeutic intervention. Abstract Despite significant improvements in treatment strategies over the past couple of decades, multiple myeloma (MM) remains an incurable disease due to the development of drug resistance. Metabolic reprogramming is a key feature of cancer cells, including MM, and acts to fuel increased proliferation, create a permissive tumour microenvironment, and promote drug resistance. This review presents an overview of the key metabolic adaptations that occur in MM pathogenesis and in the development of resistance to proteasome inhibitors, the backbone of current MM therapy, and considers the potential for therapeutic targeting of key metabolic pathways to improve outcomes.
Integrating Einstein Field Equations in Observational Coordinates with Cosmological Data Functions: Nonflat Friedmann-Lemaître-Robertson-Walker Cases

In this paper we use the integration scheme for the exact spherically symmetric Einstein field equations in observational coordinates recently developed by Araújo and Stoeger, and input data functions for area distance and galaxy number counts that would be obtained if the universe were exactly represented by nonflat Friedmann-Lemaître-Robertson-Walker models.
Quantitative Precipitation Forecasts over the United States by the ECMWF Ensemble Prediction System

Abstract The performance of the ECMWF Ensemble Prediction System (EPS) is assessed for probabilistic forecasts of 24-h accumulated precipitation over the eastern United States. Daily forecasts for the period 1 January 1997 to 31 January 1999 are verified for projections of 1–10 days. Verification is performed separately for the cool and warm seasons, and the impact of changes to the EPS that occurred during the study period is assessed. Analyses of rain gauge data from the River Forecast Centers of NOAA are used for verification. Skill is measured relative to long-term climatic frequencies, and the statistical significance of differences in the accuracy and skill among forecasts is estimated. Overall, EPS forecasts are more skillful during the winter than the summer. The EPS produces significantly skillful forecasts to past 1 week for a threshold of 1 mm in both seasons. Accuracy decreases as the threshold increases, until forecasts of 50 mm are not significantly skillful at 1 day. The implementation of e.
Influence mechanism and impacting boundary of workplace isolation on the employee's negative behaviors

Introduction Based on social identity theory, by introducing organizational identification as mediating variable and identification orientation as moderating variable, this paper studies the influence mechanism and impacting boundary of workplace isolation on employee fatigue and turnover intention. Methods Based on logic relationship, seven basic hypotheses are put forward to construct the theoretical model of the problem. Based on the 300 effective questionnaires being obtained from employees in Mainland China, the empirical investigation adopts the three-phase lag time design. By regression analysis and bootstrap test. Results (1) Workplace isolation has a significant positive effect on employee's work fatigue; (2) Workplace isolation has a significant positive effect on employee's turnover intention; (3) Organizational identification plays a partial mediating role between workplace isolation and work fatigue; (4) Organizational identification plays a partial mediating role between workplace isolation and employee's turnover intention; (5) Employee identification orientation negatively moderates the relationship between workplace isolation and organizational identification, that is to say, the higher the degree of identification orientation, the more inhibited the negative impact of workplace isolation on organizational identification; (6) Employee identification orientation has a negative moderating effect, namely, compared with the low degree of employee identification orientation, the higher the employee identification orientation, the positive effect of workplace isolation on work fatigue and turnover intention through organizational identification become weaker. Discussion Understanding these influencing mechanisms will have a great influence on guiding managers to mitigate the negative effects of “workplace isolation” in practice and improve the work efficiency of employees.
Basal Diet Fed to Recipient Mice Was the Driving Factor for Colitis and Colon Tumorigenesis, despite Fecal Microbiota Transfer from Mice with Severe or Mild Disease

Consumption of the total Western diet (TWD) in mice has been shown to increase gut inflammation, promote colon tumorigenesis, and alter fecal microbiome composition when compared to mice fed a healthy diet, i.e., AIN93G (AIN). However, it is unclear whether the gut microbiome contributes directly to colitis-associated CRC in this model. The objective of this study was to determine whether dynamic fecal microbiota transfer (FMT) from donor mice fed either the AIN basal diet or the TWD would alter colitis symptoms or colitis-associated CRC in recipient mice, which were fed either the AIN diet or the TWD, using a 2 × 2 factorial experiment design. Time-matched FMT from the donor mice fed the TWD did not significantly enhance symptoms of colitis, colon epithelial inflammation, mucosal injury, or colon tumor burden in the recipient mice fed the AIN diet. Conversely, FMT from the AIN-fed donors did not impart a protective effect on the recipient mice fed the TWD. Likewise, the composition of fecal microbiomes of the recipient mice was also affected to a much greater extent by the diet they consumed than by the source of FMT. In summary, FMT from the donor mice fed either basal diet with differing colitis or tumor outcomes did not shift colitis symptoms or colon tumorigenesis in the recipient mice, regardless of the basal diet they consumed. These observations suggest that the gut microbiome may not contribute directly to the development of disease in this animal model.
Polymeric prosthetic heart valves: A review of current technologies and future directions

Valvular heart disease is an important source of cardiovascular morbidity and mortality. Current prosthetic valve replacement options, such as bioprosthetic and mechanical heart valves are limited by structural valve degeneration requiring reoperation or the need for lifelong anticoagulation. Several new polymer technologies have been developed in recent years in the hope of creating an ideal polymeric heart valve substitute that overcomes these limitations. These compounds and valve devices are in various stages of research and development and have unique strengths and limitations inherent to their properties. This review summarizes the current literature available for the latest polymer heart valve technologies and compares important characteristics necessary for a successful valve replacement therapy, including hydrodynamic performance, thrombogenicity, hemocompatibility, long-term durability, calcification, and transcatheter application. The latter portion of this review summarizes the currently available clinical outcomes data regarding polymeric heart valves and discusses future directions of research.
Teachers’ Level of Training on ICT and the Implementation of ICT Curriculum in Some Public Primary Schools in Mezam Division, North West Region of Cameroon

Purpose: This paper buttress the importance of training teachers on use of Information and Communication Technology (ICT) as one of the major boosters the government could support implementation of ICT curriculum in Cameroon public primary schools. This study examined teachers’ level of training on ICT and implementation of ICT curriculum in some public primary schools in Mezam Division. Methodology: The study employed a mixed method research design consisting of a cross sectional survey and an interpretive phenomenology. The sample was made up of 375 teachers and 72 head teachers who were teaching in public primary schools in Mezam Division. Data was collected using questionnaires and interview guide. Data obtained was analyzed using descriptive statistical tools and thematic analysis approach. Findings: The study found that teachers’ level of training on ICT has a positive and significant influence on implementation of ICT curriculum. In order to become confident users in the classrooms, teachers require extensive, on-going exposure to ICTs to be able to develop their ICT competences, evlauate and select the most appropriate resources. Not only does training aid teachers in the development of ICT competence, it equally helps teachers to recognise ICT as an essential teaching and an enabler of other teaching and learning practices. Conclusion: This study conclude that teachers’ level of training influences the implementation of ICT curriculum. Recommendations: The study recommend that teacher training colleges should ensure that the period given for practical implementation of ICT curriculum is proportionate to the period spent in class to acquire theory on the implementation of ICT curriculum. The study also recommend Ministry of Education as well as the Regional Pedagogic Inspectors for ICT to organize regular and practical in-service training with demonstration lessons that help teachers develop basic, intermediate and advanced ICT skills.
Legal Struggles: A Social Theory Perspective on Strategic Litigation and Legal Mobilisation

Social movements, NGOs and other political actors often mobilise the law for social change. Strategic litigation and collective legal mobilisation can be key instruments to face current political challenges like the climate crisis, human rights violations against refugees or the exploitation of workers along global supply chains. Although these struggles are framed by a societal context and have impacts on the political and juridical fields, the literature about legal mobilisation still does not decidedly engage with a social-theory-based perspective on such struggles. By developing the concept of legal struggles, the article proposes a conceptual framework to analyse both the ambivalence and the emancipatory potential of progressive struggles in the juridical field. Critical Theory, Materialist Theory and the Theory of Social Fields by Pierre Bourdieu are combined to investigate the specific form of collective legal struggles carried out in this arena. We examine repertoires and strategies of collective actors as well as the emancipatory potential of these mobilisation strategies. Our conclusions point to the structural distinctions and selectivities which define the juridical field in capitalist societies and also the conditions of possibility of political struggles using the law.
The Impact of Affective Destination Image on Domestic Tourist Preferences: A Study of Gaborone City, Botswana

Visitor preferences is a personal choice of a destination for a defined purpose of travel. In most times it is influenced by value for money, intention to re-visit and the intention to recommend the destination to others. The purpose of this study was to assess the influence destinations affective image on visitor preferences in destination Gaborone City, Botswana. Descriptive survey design was used for describing the study population and their characteristics. The target population was 3750 and a sample size of 360 domestic tourists who visited Gaborone departing through SSKIA Structured questionnaires was used to collect quantitative data, and interview schedules was used to collect qualitative data. Quantitative data was analyzed using descriptive and inferential statistics. Results were presented in tables. Thematic analysis was used to analyze qualitative data. The study findings revealed R coefficient of 0.638, implying that destinations affective image as the independent factor had a correlation of 63.8 percent with visitor preferences in Gaborone City. This was supported by coefficient of determination (R-square) of 0.408. This meant that destinations affective image explained 40.8 percent of the variations in tourist preferences in Gaborone City. The study concludes that improving destination affective image has the likelihood of enhancing visitor preferences of destination in Gaborone City, Botswana. Gaborone city has a rich cultural heritage that can be showcased through cultural tourism, including cultural festivals, traditional dance performances, and visits to local museums and historical sites. By promoting cultural tourism, Gaborone can attract a niche market of travelers interested in experiencing local cultures and traditions. The study thus recommends that tourism destinations in Gaborone city needs to have a strong marketing strategy that promotes the city's unique features and attractions, including social media campaigns, collaborations with travel bloggers and influencers, and attending travel shows and exhibitions. Keywords: Affective, Destination image, Domestic tourist, Destination preferences, Gaborone City
In vitro Antibacterial Activities of Selected Medicinal Plants Used by Traditional Healers for Treating Urinary Tract Infection in Haramaya District, Eastern Ethiopia

Background Despite the presence of antibacterial agents for urinary tract infection treatment, most of the uropathogenic bacteria reveal multi-drug resistance. Health and economic loss due to these represent a rising burden worldwide which necessitates serious action at regional, national and global levels. Thus, alternative approaches to overcome this problem by using bioactive compounds from traditional medicinal plants are required. This study was designed to evaluate the in-vitro antibacterial activity of Punica granatum fruit peels, Nigella sativa seeds, and Echinops kebericho used in the traditional treatment of urinary tract infections. Methods An experimental study was employed to evaluate the in vitro antibacterial activity of methanol and ethanol crude extract of Punica granatum fruit peels, Nigella sativa seeds, and Echinops kebericho roots of six dilutions (25, 50, 100, 125, 250, and 500) mg/mL. Disc diffusion and macro broth dilution methods were used to determine antimicrobial activity test and minimum inhibitory concentration respectively against E. coli, P. aeruginosa, K. pneumoniae, P. mirabilis, and S. aureus bacterias. Results Antibacterial activities of ethanol and methanol crude extract of Punica granatum fruit peels against E. coli ATCC25922, P. aeruginosa ATCC27853, S. aureus ATCC25923, K. pneumoniae UK5099 and P. mirabilis UK5999 had highest inhibition zones among tested plants. All tested bacteria were highly sensitive to Punica granatum extract. The second most active plant extract in inhibiting the growth of tested bacteria was Nigella sativa while Echinops kebericho showed the smallest efficacy against tested bacteria. The inhibition zone diameter produced by the methanol extract of each screened plant had higher inhibition zones than ethanol extract. Conclusion The crude extracts of Punica granatum fruit peels, Nigella sativa seeds, and Echinops kebericho roots have promising antibacterial activity against tested uropathogenic bacteria.