Miracle-dz/UniFAR-FTUs huggingface dataset:
Comparison of neoadjuvant therapy and upfront surgery in resectable pancreatic cancer: a meta-analysis and systematic review

Objective: The role of neoadjuvant therapy (NAT) in resectable pancreatic cancer (RPC) remains controversial. Therefore, this meta-analysis was performed to compare the clinical differences between NAT and upfront surgery in RPC. Materials and methods: A systematic literature search was performed in PubMed, Embase, Web of Science, and the Cochrane Register of Controlled Trials databases. Only patients with RPC who underwent tumor resection and received adjuvant or neoadjuvant treatment were enrolled. The OR or HR and 95% CIs were calculated employing fixed-effects or random-effects models. The HR and its 95% CI were extracted from each article that provided survival curve. Publication bias was estimated using funnel plots and Egger’s regression test. Results: In total, eleven studies were included with 9,386 patients. Of these patients, 2,508 (26.7%) received NAT. For patients with RPC, NAT resulted in an increased R0 resection rate (OR = 1.89; 95% CI = 1.26–2.83) and a reduced positive lymph node rate (OR = 0.34; 95% CI = 0.31–0.37) compared with upfront surgery. Nevertheless, patients receiving NAT did not exhibit a significantly increased overall survival (OS) time (HR = 0.91; 95% CI = 0.79–1.05). Conclusion: In patients with RPC, R0 resection rate and positive lymph node rate after NAT were superior to those of patients with upfront surgery. The NAT group exhibited no significant effect on OS time when compared with the upfront surgery group. However, this conclusion requires more clinical evidence to improve its credibility.
New investigations into macular pigment optical density

Macular pigment (MP) is the collective name for three carotenoids, lutein, zeaxanthin and meso-zeaxanthin, which are found at high concentrations in the central macula. The macular carotenoids, like all carotenoids, are entirely of dietary origin. The term ‘macular pigment optical density’ (MPOD) refers to the peak concentration of MP in the retina, which varies from one individual to the next and is measurable in vivo. On account of its blue-light-filtering and antioxidant properties, MP has become a subject of interest with respect to age-related macular degeneration (AMD), the hypothesis being that MP helps to protect against AMD; the higher the MPOD, the lower the risk for AMD. Recently, a new MPOD-measuring device, the MPS 9000 (MPS), entered the ophthalmic market. Using this device, the research described here aimed to contribute new information to the MP literature. A second MPOD instrument, the Macular Pigment Reflectometer, was also used at times, but a reliability study (included in the thesis) demonstrated that it was unsuitable for use on its own. First, a series of exploratory investigations were undertaken to maximize the accuracy and consistency of MPOD measurements taken with the MPS; a protocol was established that substantially improved repeatability. Subsequently, a series of MPOD-based studies were conducted on anisometropia, South Asian race, blue-light-filtering contact lenses, and dietary modification with kale. The principle findings were as follows: interocular MPOD differences were not attributable to interocular refractive error differences; young adults of South Asian origin had significant gender-related MPOD differences (males>females, p<0.01), and they also had significantly higher MPOD than Caucasians (p<0.0005); wearing blue-light-filtering contact lenses for eight months did not affect MPOD; and dietary modification with kale for 16 weeks did not increase MPOD. This body of research adds new insights to MP knowledge, which in turn may contribute to MP knowledge in the context of AMD.
Studying Programmer Behavior Experimentally : The Problems of Proper Methodology

This category includes software-based critical tools for implementing military systems, the CAD/CAM systems, the critical software development tools described in subsection 3.2, and the many commercial application packages that have absolutely no military significance. Therefore, the CNCTEG recommends that this category be controlled initially, and that a high priority effort be placed on further subdividing it so that many of the products in the category may be freed from control, thus reducing the administrative workload related to export licenses for software having no military significance.
Phenotypic and transcriptomic analysis reveals early stress responses in transgenic rice expressing Arabidopsis DREB1a

Overexpression of Arabidopsis Dehydration Response Element Binding 1a (DREB1a) is a well-known approach for developing salinity, cold and/or drought stress tolerance. However, understanding of the genetic mechanisms associated with DREB1a expression in rice is generally limited. In this study, DREB1a associated early responses were investigated in a transgenic rice line harboring cold-inducible DREB1a at a gene stacked locus. While the function of other genes in the stacked locus was not relevant to stress tolerance, this study demonstrates DREB1a can be colocalized with other genes for multigenic trait enhancement. As expected, the transgenic lines displayed improved tolerance to salinity stress and water withholding when compared to non-transgenic controls. RNA sequencing and transcriptome analysis showed upregulation of complex transcriptional networks and metabolic reprogramming as DREB1a expression led to the upregulation of multiple transcription factor gene families, suppression of photosynthesis and induction of secondary metabolism. In addition to the detection of previously described mechanisms such as production of protective molecules, potentially novel pathways were also revealed. These include jasmonate, auxin, and ethylene signaling, induction of JAZ and WRKY regulons, trehalose synthesis and polyamine catabolism. These genes regulate various stress responses and ensure timely attenuation of the stress signal. Furthermore, genes associated with heat stress response were downregulated in DREB1a overexpressing lines, suggesting antagonism between heat and dehydration stress pathways. In summary, through a complex transcriptional network, multiple stress signaling pathways are induced by DREB1a that presumably lead to early perception and rapid response towards stress tolerance as well as attenuation of the signal to prevent deleterious effects of the runoff response.
How Effective are Lateral Wedge Orthotics in Treating Medial Compartment Osteoarthritis of the Knee? A Systematic Review of the Recent Literature

Lateral wedges were originally proposed to manage medial compartment osteoarthritis of the knee but recent reviews suggest that lateral wedges do not affect disease progression. We performed a systematic review to analyse the recent literature and define how effective, if at all, lateral wedges are in the management of medial compartment osteoarthritis of the knee. The inclusion criteria were defined as any study published within the last decade, using a sample size of at least twenty patients, and investigating the effect of insoles or wedges on either unilateral or bilateral knee varus osteoarthritis. The standardised keyword term ‘lateral*wedge*OR insole*OR orthotic* OR medial compartment OR varus OR osteoarthri* OR knee*’ was used. We identified 10 studies that fitted our inclusion criteria. Although there is not enough evidence in the literature to prove that lateral wedge orthotics are an effective treatment for varus osteoarthritis of the knee, there is some evidence to suggest that they do have some symptomatic effect. Patients with early osteoarthritis and higher BMI may benefit to a greater extent than those with a greater extent of degenerative changes and lower BMI. The literature is unclear as to what the optimal duration for the use of lateral wedges is, but does support the prolonged use of the wedges as the benefits at one month are maintained at one year. Future studies should be randomised controlled trials with a large sample size with long follow-up, and use objective clinical, biomechanical and radiological outcome measures.
Assessing Stages of Team Development in a Summer Enrichment Program

v Chapter 1: Nature and Scope of the Study 1 Stages of Group Development 1 Teams: Definition and Stages 3 Marshall University Summer Enrichment Program and Teams 5 Evaluating Teams in the MUSEP 7 Purpose of this Study 11 Chapter 2: Method 13 Participants 13 Instruments 13 Procedure 14 Data Analysis 14 Chapter 3: Results 16 Chapter 4: Discussion 20
Abatacept inhibits radiographic progression in patients with rheumatoid arthritis: a retrospective analysis of 6 months of abatacept treatment in routine clinical practice. The ALTAIR study

ObjectivesOur objectives in this study were to determine the inhibitory effects of abatacept on joint damage and its clinical efficacy and safety in patients with rheumatoid arthritis (RA). MethodsFifty Japanese patients with RA were treated with abatacept for 24 weeks in routine clinical practice.ResultsAt week 24, 20 % of patients achieved clinical remission [Simplified Disease Activity Index (SDAI) ≤3.3], whereas 50 % were in remission or had a low disease activity. Structural remission [progression of modified total Sharp score (ΔmTSS) ≤0.5] was achieved in 76 % of patients. The ΔmTSS decreased significantly from 7.1 ± 7.3 at baseline to 1.8 ± 5.7 at week 24. C-reactive protein (CRP) was the only independent prognostic factor for joint damage progression at week 24, whereas SDAI and matrix metalloproteinase-3 levels were not. A very high proportion of patients with CRP levels <1.5 mg/dl (88 %) achieved structural remission. In terms of safety, the retention rate for all patients was favorable (80 %), and stomatitis was the only adverse event observed. No patient withdrew from the study because of infections.ConclusionsAbatacept has favorable clinical and structural effects, inhibits radiographic progression, and has a good safety profile in routine clinical practice.
Computers in Human Behavior

In this paper, we propose a novel approach to the analysis of collaborative learning. The approach posits that di ﬀ erent dimensions of collaborative learning emerging from social ties and content analysis of discourse can be modeled as networks. As such, the combination of social network analysis (SNA) and epistemic network analysis (ENA) analysis can detect information about a learner's enactment of what the literature on collaborative learning has described as a role: an ensemble of cognitive and social dimensions that is marked by interacting with the appropriate people about appropriate content. The proposed approach is named social epistemic network signature (SENS) and is de ﬁ ned as a combination of these two complementary network analytic techniques. The proposed SENS approach is examined on data produced in collaborative activities performed in a massive open online course (MOOC) delivered via a major MOOC platform. The results of a study conducted on a data set collected in a MOOC suggest SNA and ENA produce complementary results which can i) explain collaboration processes that shaped the creation of social ties and that were associated with di ﬀ erent network roles; ii) describe di ﬀ erences between low and high performing groups of learners; and iii) show how combined properties derived from SNA and ENA predict academic performance.
Communication in personal relationships across cultures

This innovative book contains studies of personal relationships from a variety of non-western cultures, and leaves behind the western biases that are typical of most research and theorizing done in this expanding area. Chapters focus on personal communication practices in countries including Iran, Brazil, Mexico, China, Japan and Korea. The editors cover the major theories that explain communication across cultures through both emic and etic approaches, by examining how members of a culture understand their own communication, and by comparing specific aspects of communication across cultures. They also suggest areas for future research.
How often is Employee Anger an Insider Risk I? Detecting and Measuring Negative Sentiment versus Insider Risk in Digital Communications

This research introduced two new scales for the identification and measurement of negative sentiment and insider risk in communications in order to examine the unexplored relationship between these two constructs. The inter-rater reliability and criterion validity of the Scale of Negativity in Texts (SNIT) and the Scale of Insider Risk in Digital Communications (SIRDC) were established with a random sample of email from the Enron archive and criterion measures from established insiders, disgruntled employees, suicidal, depressed, angry, anxious, and other sampled groups. In addition, the sensitivity of the scales to changes over time as the risk of digital attack increased and transitioned to a physical attack was also examined in an actual case study. Inter-rater reliability for the SNIT was extremely high across groups while the SIRDC produced lower, but acceptable levels of agreement. Both measures also significantly distinguished the criterion groups from the overall Enron sample. The scales were then used to measure the frequency of negative sentiment and insider risk indicators in the random Enron sample and the relationship between the two constructs. While low levels of negative sentiment were found in 20% of the sample, moderate and high levels of negative sentiment were extremely rare, occurring in less than 1% of communications. Less than 4% of the sampled emails displayed indicators of insider risk on the SIRDC. Emails containing high levels of insider risk comprised less than one percent or the sample. Of the emails containing negative sentiment in the sample, only 16.3%, also displayed Journal of Digital Forensics, Security and Law, Vol. 8(1) 40 indicators of insider risk. The odds of a communication containing insider risk increased with the level of negative sentiment and only low levels of insider risk were found at low levels of negative sentiment. All of the emails found to contain insider risk indicators on the SIRDC also displayed some level of negative sentiment. The implications of these findings for insider risk detection were then examined.
sleep problems in children with autism spectrum disorder: clinical correlates and the impact of attention deficit hyperactivity disorder

Purpose: High prevalence of sleep problems has been reported in children with autism spectrum disorder (ASD). However, there is limited literature about the types and clinical correlates of sleep problems. This study aims to compare sleep disturbances between children with ASD and healthy children and investigate the relationship between sleep difficulties and clinical symptoms of ASD. Materials and methods: The sample consisted of 112 children in ASD patient group and 112 healthy controls, with an age range of 2–18 years. The Children’s Sleep Habits Questionnaire (CSHQ) was used for sleep problems; Turgay DSM-IV Disruptive Behavior Disorders Rating Scale parent form (T-DSM-IV-S) was used to assess hyperactivity/impulsivity and inattentiveness; Childhood Autism Rating Scale (CARS), Autism Behavior Checklist, and Aberrant Behavior Checklist were used to evaluate the severity of autistic symptoms and behavioral problems. Results: Total score, bedtime resistance, and sleep anxiety subscores of CSHQ were significantly higher in children with ASD than the control group. Among ASD children, intellectual capacity was not found to be associated with CSHQ scores. Bedtime resistance and night waking subscores of CSHQ were found to be positively correlated with CARS total score. Inattentiveness subscore of Parent T-DSM-IV-S was significantly higher in children with moderate-to-severe sleep problems. Conclusion: Sleep difficulties in ASD patients may occur independently of intellectual disability. Bedtime resistance and night waking appear to be linked with ASD symptoms. Inattentiveness in ASD children may be associated with moderate-to-severe sleep problems.
Information Management & Computer Security E-commerce assurance models and trustworthiness issues : an empirical study

Purpose – The internet provides a mechanism by which buyers and sellers meet in order to exchange goods and services online with the utmost convenience. However, there are many risks associated with the internet which, if left unattended, could continue deterring the adoption of e-commerce. These risks ultimately diminish online consumer trust in e-commerce. Web assurance models have been designed in an attempt to encourage online consumer trust through assurance. Unfortunately, many of these models have been inadequate in certain areas and this research aims to improve on them. Design/methodology/approach – It presents a comprehensive empirical survey on trustworthiness issues and e-commerce assurance models and proposes a new compliance-based e-commerce assurance model that integrates adaptive legislation, adaptive e-commerce-related standards and cooperative rating. The intelligent cooperative rating is based on the analytic hierarchy process and page-ranking techniques. Findings – Some findings of this research study influence the thinking that some of the untrustworthy sites are posing as trustworthy sites because they display web seals. The findings can be used as a reference guide to understand e-commerce assurance models, as well as the effectiveness of ensuring the trustworthiness of these models. Practical implications – The research presents deployment analysis on the use of the proposed compliance model through real life scenarios categorized as trustworthy and untrustworthy e-commerce web sites. Originality/value – This research is relevant to information management and computer security in e-commerce as a development of a newly proposed e-commerce assurance model for trustworthiness safety inspections and knowledge generation as a reference guide to understand e-commerce trustworthiness in general and e-commerce assurance models in particular detail.
CMAR_A_256219 7797..7803

1Department of General Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, People’s Republic of China; 2Department of Clinical Nutrition, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, People’s Republic of China; 3Ninth School of Clinical Medicine, Peking University, Beijing 100038, People’s Republic of China; 4Department of Nursing, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, People’s Republic of China
Video Summarization Using R-Sequences

In this paper, we propose a new method of temporal summarization of digital video. First, we address the problem of extracting a fixed number of representative frames to summarize a given digital video. To solve it, we have devised an algorithm called content-based adaptive clustering (CBAC). In our algorithm, shot boundary detection is not needed. Video frames are treated as points in the multi-dimensional feature space corresponding to a low-level feature such as color, motion, shape and texture. The changes of their distances are compared globally for extraction of representative frames. Second, we address how to use the representative frames to comprise representative sequences (R - Sequence) which can be used for temporal summarization of video. A video player based on our devised algorithm is developed which has functions of content-based browsing and content-based video summary. Experiments are also shown in the paper.
Hubungan Derajat Miopia Dengan Kejadian Degenerasi Lattice

Degenerasi lattice merupakan degenerasi retina perifer yang terjadi akibat peregangan pada retina dan koroid sehingga terjadi penurunan sirkulasi darah serta penipisan pada retina, terutama retina perifer. Degenerasi lattice lebih sering terjadi pada mata miopia daripada mata non-miopia. Mata miopia yang disertai dengan lesi degenerasi lattice merupakan faktor risiko penting dalam terjadinya ablasio retina yang jika tidak ditangani dapat menyebabkan kebutaan. Penelitian ini bertujuan untuk mengetahui presentase derajat miopia yang mengalami degenerasi lattice dan mengetahui hubungan antara derajat miopia dengan kejadian degenerasi lattice. Metode penelitian ini menggunakan penelitian observasional analitik dengan desain cross-sectional. Penelitian dilakukan di klinik mata SMEC Samarinda dari bulan April - Juni 2016 dengan responden penelitian sebanyak 66 mata miopia dari 35 pasien berusia 20-40 tahun. Miopia terbagi menjadi derajat ringan ( 6 D). Seluruh responden penelitian dilakukan pemeriksaan koreksi refraksi dan pemeriksaan oftalmoskopi indirek oleh dokter spesialis mata. Penelitian ini didapatkan kejadian degenerasi lattice pada mata miopia sebesar 36,4% (24 mata dari 66 mata). Degenerasi lattice pada mata miopia derajat ringan ditemukan sebesar 15,6% (5 mata dari 32 mata). Pada mata miopia derajat sedang sebesar 47,6% (10 mata dari 21 mata ), dan sebesar 69,2% (9 mata dari 13 mata) degenerasi lattice pada miopia derajat berat. Hasil analisis menunjukkan adanya hubungan antara derajat miopia dan kejadian degenerasi lattice dengan nilai p=0,001 (p<0,05). Dapat disimpulkan bahwa terdapat hubungan antara derajat miopia dengan degenerasi lattice. Kata Kunci : Degenerasi Lattice, Miopia.
Fluorinated synthetic anion carriers: experimental and computational insights into transmembrane chloride transport. Chemical

A series of ﬂ uorinated tripodal tris-thioureas function as highly active anion transporters across lipid bilayers and cell membranes. Here, we investigate their mechanism of action using anion transport assays in cells and synthetic vesicles and molecular modelling of transporter – lipid interactions. When compared with non- ﬂ uorinated analogues, ﬂ uorinated compounds demonstrate a di ﬀ erent mechanism of membrane transport because the free transporter cannot e ﬀ ectively di ﬀ use through the membrane. As a result, in H + /Cl (cid:1) cotransport assays, ﬂ uorinated transporters require the presence of oleic acid to form anionic oleate complexes for recycling of the transporter, whereas non- ﬂ uorinated analogues readily di ﬀ use through the membrane as free transporters and show synergistic transport with the proton transporter gramicidin. Molecular dynamics simulations revealed markedly stronger transporter – lipid interactions for ﬂ uorinated compounds compared with non- ﬂ uorinated analogues and hence, higher energy barriers for ﬂ uorinated compounds to cross the membrane as free transporters. With use of appropriate proton transporters to ensure measurement of the correct rate-limiting steps, the transport rates determined in synthetic vesicle assays show excellent agreement with the anion transport rates determined in cell-based assays. We conclude that integration of computational and experimental methods provides a strategy to optimise transmembrane anion transporter design for biomedical applications.
Resourceful Actors, Not Weak Victims: Reframing Refugees’ Stigmatized Identity Enhances Long-Term Academic Engagement

Refugees suffer from a stigmatized identity portraying them as weak, unskilled victims. We developed a brief (~10-min) intervention that reframed refugees’ identity as being, by its very nature, a source of strength and skills. Reading and writing exercises, provided by a university, highlighted how refugees’ experiences helped them acquire skills such as perseverance and the ability to cope with adversity, which could help them succeed in a new country. In Experiment 1 (N = 93), the intervention boosted refugees’ (a) confidence in their ability to succeed at an imagined university and (b) challenge seeking: Participants were 70% more likely to take on an academic exercise labeled as difficult. In Experiment 2, the intervention, delivered to refugees entering an online university (N = 533), increased engagement in the online-learning environment by 23% over the subsequent year. There was also evidence of greater course completion. It is possible to reframe stigmatized individuals’ identity as inherently strong and resourceful, helping them put their strengths to use.