Miracle-dz/UniFAR-FTUs huggingface dataset:
S0950268822001650jra 1..8

We developed an agent-based model using a trial emulation approach to quantify effect measure modification of spillover effects of pre-exposure prophylaxis (PrEP) for HIV among men who have sex with men (MSM) in the Atlanta-Sandy Springs-Roswell metropolitan area, Georgia. PrEP may impact not only the individual prescribed, but also their partners and beyond, known as spillover. We simulated a two-stage randomised trial with eligible components (≥3 agents with ≥1 HIV+ agent) first randomised to intervention or control (no PrEP). Within intervention components, agents were randomised to PrEP with coverage of 70%, providing insight into a high PrEP coverage strategy. We evaluated effect modification by component-level characteristics and estimated spillover effects on HIV incidence using an extension of randomisation-based estimators. We observed an attenuation of the spillover effect when agents were in components with a higher prevalence of either drug use or bridging potential (if an agent acts as a mediator between ≥2 connected groups of agents). The estimated spillover effects were larger in magnitude among components with either higher HIV prevalence or greater density (number of existing partnerships compared to all possible partnerships). Consideration of effect modification is important when evaluating the spillover of PrEP among MSM.
SkinMixer

We propose a novel technique to compose new 3D animated models, such as videogame characters, by combining pieces from existing ones. Our method works on production-ready rigged, skinned, and animated 3D models to reassemble new ones. We exploit mix-and-match operations on the skeletons to trigger the automatic creation of a new mesh, linked to the new skeleton by a set of skinning weights and complete with a set of animations. The resulting model preserves the quality of the input meshings (which can be quad-dominant and semi-regular), skinning weights (inducing believable deformation), and animations, featuring coherent movements of the new skeleton. Our method enables content creators to reuse valuable, carefully designed assets by assembling new ready-to-use characters while preserving most of the hand-crafted subtleties of models authored by digital artists. As shown in the accompanying video, it allows for drastically cutting the time needed to obtain the final result.
Measurement and calculation of acoustic propagation constants in arrays of small air-filled rectangular tubes

An experimental and theoretical investigation of sound propagation in a porous sample composed of capillary tubes with rectangular cross sections is described in this paper. An experimental technique valid for low flow resistivity and high porosity porous samples was developed to measure the attenuation and phase velocity in the porous material. This technique uses transmission of a short pulse in a large tube through the porous sample and subsequent frequency domain analysis in the range 200–1300 Hz. Good agreement was obtained if an anomalous tortuosity factor of 1.1 is used in the theory. A scaling factor for relating cylindrical and square tube capillary theories, known as the dynamic shape factor, was investigated. Propagation constants computed from use of a near unity dynamic shape factor in the cylindrical pore theory agree favorably with calculations based on the square pore theory for the frequencies and pore radii used in the experiment.
Artificial Neural Network based Power Control in D2D Communication

— As a viable technique for next-generation wireless networks, Device-to-Device (D2D) communication has attracted interest because it encourages the usage of point-to-point communications between User Equipment (UE) without passing over base stations (BS). Device-to-device (D2D) communication has been proposed in cellular networks as a supplementary paradigm to primarily increase network connection. This research takes into account a cellular network where users are trying device-to-device (D2D) connection. A D2D pair is composed of two D2D users (DUEs), a transmitter, and a receiver. To improve spectral efficiency, we use the premise that the D2D pairs only employ one communication channel. In order to minimize interference between D2D pairs and increase capacity, a power control is required. In the scenario where only typical cellular channel gains between base stations and DUEs are known and channel gains among DUEs are completely inaccessible, we address the issue of D2D power control. For each individual D2D pair, we use an artificial neural network (ANN) to calculate the transmission power. We show that the maximum aggregate capacity for the D2D pairs may be reached while anticipating the transmission power setting for D2D pairs using cellular channel gains.
The unexpected versatility of ALP/Enigma family proteins

One of the most intriguing features of multicellular animals is their ability to move. On a cellular level, this is accomplished by the rearrangement and reorganization of the cytoskeleton, a dynamic network of filamentous proteins which provides stability and structure in a stationary context, but also facilitates directed movement by contracting. The ALP/Enigma family proteins are a diverse group of docking proteins found in numerous cellular milieus and facilitate these processes among others. In vertebrates, they are characterized by having a PDZ domain in combination with one or three LIM domains. The family is comprised of CLP-36 (PDLIM1), Mystique (PDLIM2), ALP (PDLIM3), RIL (PDLIM4), ENH (PDLIM5), ZASP (PDLIM6), and Enigma (PDLIM7). In this review, we will outline the evolution and function of their protein domains which confers their versatility. Additionally, we highlight their role in different cellular environments, focusing specifically on recent advances in muscle research using Drosophila as a model organism. Finally, we show the relevance of this protein family to human myopathies and the development of muscle-related diseases.
Resistance to thyroid hormone beta coexisting with papillary thyroid carcinoma—two case reports of a thyroid hormone receptor beta gene mutation and a literature review

Resistance to thyroid hormone beta (RTHβ) is an autosomal dominant hereditary disorder that is difficult to diagnose because of its rarity and variable clinical features, which are caused by mutations in the thyroid hormone receptor beta (THRB) gene. Recent studies have indicated a close association between THRB mutations and human cancers, but the mechanistic role of THRB mutations in carcinogenesis is unknown. Herein, we report two cases of RTHβ coexisting with papillary thyroid carcinoma (PTC) and their follow-up results. Two female patients presented with elevated serum thyroid hormone levels and nonsuppressed thyrotropin (TSH). Genetic analysis showed that each patient had a THRB gene mutation (p.P453T and p. R320H). Based on the results of ultrasound-guided fine-needle aspiration biopsy, the thyroid nodules were suspected to be PTC. Intraoperative pathology confirmed that the two patients had PTC with multifocal carcinoma of both lobes. One patient underwent total thyroidectomy and central lymph node dissection, and the other underwent total thyroidectomy alone. Following surgery, large doses of levothyroxine were administered to suppress TSH levels and prevent recurrent or persistent disease. However, it is difficult to continually suppress TSH levels below the upper limit of the normal range. To date, the two patients have experienced no recurrence of PTC on ultrasound. Graphical Abstract Whole exome sequencing.
Extreme coastal water levels with potential flooding risk at the low-lying Saint Louis historic city, Senegal (West Africa)

In a context of global warming characterized by a mean sea level rise and extreme meteorological events, the study of the causes for coastal flooding is essential to protect communities and ecosystems. Densely urbanized, and rather unprotected cities in developing countries such as the historic Saint Louis city in Senegal are particularly vulnerable to coastal flooding and sea hazards. From satellite-derived high resolution DEM and global ocean reanalyses, here we quantify the extreme coastal water level in order to identify the neighborhoods and places of particular socio-economical interest of Saint-Louis potentially vulnerable to flooding. The results reveal that the most severe levels have the potential to flood up to almost half of this low-lying river mouth plain. Social, economic and heritage stakes are exposed, and the artisanal fisherman district of Gueth Ndar, is particularly vulnerable to coastal flooding because of its low elevation and situation on the sand barrier. The co-occurrence of high tides and wave-induced runup contributes most to ECWL but they do not present a significant trend over the study period. The results show that over the period 1994-2015, potential flood risk increased by nearly one day per year, primarily due to sea level rise, sounding a warning signal to take countermeasures to protect communities and infrastructure.
Invasive assessment of aortic stenosis in contemporary practice

The authors review the current role of cardiac catheterization in the characterization of aortic stenosis, its main clinical applications, its pitfalls, and its additional value to the information provided by echocardiography. Discrepancies that may arise between these two modalities are discussed and further explained. Hemodynamic variables besides transvalvular pressure drop are described, and emphasis is given to an integrative approach to aortic stenosis assessment, that includes invasive and noninvasive evaluation.
Treatment recommendations for non-HIV associated cryptococcal meningoencephalitis including management of post-infectious inflammatory response syndrome

Cryptococcal meningoencephalitis (CM) continues to cause major morbidity and mortality in a range of patients such as those immunosuppressed from HIV and with biologic immunosuppressants, including treatments of autoimmunity, malignancies, and conditioning regimens for transplantation. It is currently the most common cause of non-viral meningitis in the United States. Infections in previously healthy patients also develop with autoantibodies to granulocyte-macrophage colony stimulating factor or with monogenetic defects. In all populations, mortality and significant long-term morbidity occur in 30–50% despite therapy, and immune reconstitution and post-infectious inflammatory response syndromes complicate management. To help with these difficult cases, we present here a practical tutorial of the care of a range of patients with CM in the absence of HIV/AIDS.
Taxonomic diversity and eco-exergy changes in fishery resources associated with artificial reefs over 14 years in Daya Bay, China

Marine habitat degradation resulting from human activities and environmental pollution has led to serious deterioration of marine fishery resources. To address this issue, countries worldwide are exploring sustainable fishery approaches. Installation of artificial reefs (AR) is rapidly increasing. AR have been widely constructed globally to conserve fishery resources and improve marine habitats. As an important biological group of marine fishery resources, nekton are widely evaluated to determine the effects of ecological restoration and resource conservation. In the current study, we compared the dynamic properties of taxonomic diversity and the eco-exergy of nekton community from 2 to 14 years after AR construction in Dalajia, China. The results indicated that the species number and density of nekton significantly increased after AR construction. Siganus oramin became an absolute dominant fish species in the reef area and its surroundings. The species diversity and evenness of the nekton community decreased, whereas species richness increased. The abundance, biomass, and eco-exergy of the nekton community increased over time because of the dominance of fishes. Our results highlight that AR can increase and conserve fishery resources, improve the structure of the nekton community, and increase ecosystem stability. But, at the same time, the dominance of S. oramin can interfere in the reef community. The explosive growth was quantitatively and qualitatively higher than that of other species, the diversity and evenness indices showed a decreasing trend, although the number of nekton species was significantly higher than that in the background survey and CA habitat during the same period.
Alpha retinal ganglion cells in pigmented mice retina: number and distribution

Purpose: To identify and characterize numerically and topographically the population of alpha retinal ganglion cells (αRGCs) and their subtypes, the sustained-response ON-center αRGCs (ONs-αRGCs), which correspond to the type 4 intrinsically photosensitive RGCs (M4-ipRGCs), the transient-response ON-center αRGCs (ONt-αRGCs), the sustained-response OFF-center αRGCs (OFFs-αRGCs), and the transient-response OFF-center αRGCs (OFFt-αRGCs) in the adult pigmented mouse retina. Methods: The αRGC population and its subtypes were studied in flat-mounted retinas and radial sections immunodetected against non-phosphorylated high molecular weight neurofilament subunit (SMI-32) or osteopontin (OPN), two αRGCs pan-markers; Calbindin, expressed in ONs-αRGCs, and amacrines; T-box transcription factor T-brain 2 (Tbr2), a key transcriptional regulator for ipRGC development and maintenance, expressed in ipRGCs and GABA-displaced amacrine cells; OPN4, an anti-melanopsin antibody; or Brn3a and Brn3c, markers of RGCs. The total population of RGCs was counted automatically and αRGCs and its subtypes were counted manually, and color-coded neighborhood maps were used for their topographical representation. Results: The total mean number of αRGCs per retina is 2,252 ± 306 SMI32+αRGCs and 2,315 ± 175 OPN+αRGCs (n = 10), representing 5.08% and 5.22% of the total number of RGCs traced from the optic nerve, respectively. αRGCs are distributed throughout the retina, showing a higher density in the temporal hemiretina. ONs-αRGCs represent ≈36% [841 ± 110 cells (n = 10)] of all αRGCs and are located throughout the retina, with the highest density in the temporal region. ONt-αRGCs represent ≈34% [797 ± 146 cells (n = 10)] of all αRGCs and are mainly located in the central retinal region. OFF-αRGCs represent the remaining 32% of total αRGCs and are divided equally between OFFs-αRGCs and OFFt-αRGCs [363 ± 50 cells (n = 10) and 376 ± 36 cells (n = 10), respectively]. OFFs-αRGCs are mainly located in the supero-temporal peripheral region of the retina and OFFt-αRGCs in the mid-peripheral region of the retina, especially in the infero-temporal region. Conclusions: The combination of specific antibodies is a useful tool to identify and study αRGCs and their subtypes. αRGCs are distributed throughout the retina presenting higher density in the temporal area. The sustained ON and OFF response subtypes are mainly located in the periphery while the transient ON and OFF response subtypes are found in the central regions of the retina.
Spatial differences, distributional dynamics, and driving factors of green total factor productivity in China

Green total factor productivity (GTFP) is a major driver of environmental governance, climate change mitigation, and green transformation in China. This study aims to improve GTFP, reduce regional differences, and promote sustainable development. Herein, the slacks-based measure-global Malmquist–Luenberger index was used for the scientifically rigorous measurement of China’s GTFP from 2000 to 2019. Dagum’s Gini coefficient decomposition and kernel density estimation methods were used to explore GTFP regional differences and distributional dynamics. Finally, spatial GTFP heterogeneity driving factors were analyzed using a geodetector tool. We found that China’s GTFP is on an overall upward trend, driven mainly by technological progress. There were substantial spatial differences in China’s GTFP, primarily caused by transvariation intensity, the average contribution of which is 43.26%. Differences in GTFP between and within regions decreased to varying degrees over time. Spatial heterogeneities in China’s GTFP were primarily caused by driving factors interactions, which were stronger than their individual effects. Thus, we recommend that China should accelerate the establishment of a new coordinated regional development mode, improve its green technology innovation capacity, increase openness, and push for a green model of development. Graphical Abstract Flow chart of China GTFP.
Resilience of hop (Humulus lupulus L.) to salinity, heat and drought stresses: A mini-review

Over recent years, the cultivation of hops (Humulus lupulus L.) has spread widely in the Mediterranean, also affecting the southern regions of Spain and Italy with a typical semi-arid climate. Several and recent studies have investigated the responses of this species to the main abiotic stresses, which is an aspect of absolute relevance to the knowledge of the adaptive capacity of hops to the growing conditions of a new cultivation environment. Moreover, given the fact that hops’ phytochemical composition is determined primarily by genetic and environmental factors, and that the species is perennial, the lack of knowledge on the effects of abiotic stress could be reflected in subsequent years, which means multi-year economic risks. This review work therefore aims to showcase, based on an in-depth investigation of the available literature, the response of hop to the main abiotic stresses, and the effect of these on productive and qualitative crop performances. The data presented will be useful to the understanding of constraints and to the identification of useful coping strategies to the cultivation of hops in semi-arid Mediterranean environments.
A novel approach for quantitative electrogram analysis for driver identification: Implications for ablation in persistent atrial fibrillation

Objective This study sought to study the feasibility, efficacy, and safety of using multiscale entropy (MSE) analysis to guide catheter ablation for persistent atrial fibrillation (PsAF) and predict ablation outcomes. Methods We prospectively enrolled 108 patients undergoing initial ablation for PsAF. MSE was calculated based on bipolar intracardiac electrograms (iEGMs) to measure the dynamical complexity of biological signals. The iEGMs data were exported after pulmonary vein isolation (PVI), then calculated in a customed platform, and finally re-annotated into the CARTO system. After PVI, regions of the highest mean MSE (mMSE) values were ablated in descending order until AF termination, or three areas had been ablated. Results Baseline characteristics were evenly distributed between the AF termination (n = 38, 35.19%) and the non-termination group. The RA-to-LA mean MSE (mMSE) gradient demonstrated a positive gradient in the non-termination group and a negative gradient in the termination group (0.105 ± 0.180 vs. −0.235 ± 0.256, P < 0.001). During a 12-month follow-up, 29 patients (26.9%) had arrhythmia recurrence after single ablation, and 18 of them had AF (62.1%). The termination group had lower rates of arrhythmia recurrence (15.79 vs. 32.86%, Log-Rank P = 0.053) and AF recurrence (10.53 vs. 20%, Log-Rank P = 0.173) after single ablation and a lower rate of arrhythmia recurrence (7.89 vs. 27.14%, Log-Rank P = 0.018) after repeated ablation. Correspondingly, subjects with negative RA-to-LA mMSE gradient had lower incidences of arrhythmia (16.67 vs. 35%, Log-Rank P = 0.028) and AF (16.67 vs. 35%, Log-Rank P = 0.032) recurrence after single ablation and arrhythmia recurrence after repeated ablation (12.5 vs. 26.67%, Log-Rank P = 0.062). Marginal peri-procedural safety outcomes were observed. Conclusion MSE analysis-guided driver ablation in addition to PVI for PsAF could be feasible, efficient, and safe. An RA < LA mMSE gradient before ablation could predict freedom from arrhythmia. The RA-LA MSE gradient could be useful for guiding ablation strategy selection.
Lie theory and separation of variables. 5. The equations iUt + Uxx = 0 and iUt + Uxx −c/x2 U = 0

A detailed study of the group of symmetries of the time‐dependent free particle Schrodinger equation in one space dimension is presented. An orbit analysis of all first order symmetries is seen to correspond in a well‐defined manner to the separation of variables of this equation. The study gives a unified treatment of the harmonic oscillator (both attractive and repulsive), Stark effect, and free particle Hamiltonians in the time dependent formalism. The case of a potential c/x2 is also discussed in the time dependent formalism. Use of representation theory for the symmetry groups permits simple derivation of expansions relating various solutions of the Schrodinger equation, several of which are new.
Integrated investigation of the prognostic role of HLA LOH in advanced lung cancer patients with immunotherapy

Although multiple studies have shown that loss of heterozygosity (LOH) at the human leukocyte antigen (HLA) locus is one of the mechanisms of immune escape, the effect of HLA LOH on the immunotherapy response of patients is still unclear. Based on the data of 425 Chinese lung cancer patients, the genomic characteristics with different HLA LOH statuses were analyzed. The driver genes mutation frequency, oncogenic signaling pathways mutation frequency, tumor mutational burden (TMB) and chromosomal instability (CIN) score in the HLA LOH high group was significantly higher than in the HLA LOH negative group. Transcriptome analyses revealed that pre-existing immunologically active tumor microenvironment (TME) was associated with HLA LOH negative patients. Non-small cell lung cancer (NSCLC) patients, especially for lung squamous cell carcinomas (LUSC), with HLA LOH negative have a longer survival period than those with HLA LOH. In addition, the combination of HLA LOH with TMB or programmed cell death-Ligand 1 (PD-L1) expression can further distinguish responders from non-responders. Furthermore, a comprehensive predictive model including HLA LOH status, TMB, PD-L1 expression and CD8+ T cells was constructed and exhibited a higher predictive value, which may improve clinical decision-making.
Transcriptome and proteome profiling of activated cardiac fibroblasts supports target prioritization in cardiac fibrosis

Background Activated cardiac fibroblasts (CF) play a central role in cardiac fibrosis, a condition associated with most cardiovascular diseases. Conversion of quiescent into activated CF sustains heart integrity upon injury. However, permanence of CF in active state inflicts deleterious heart function effects. Mechanisms underlying this cell state conversion are still not fully disclosed, contributing to a limited target space and lack of effective anti-fibrotic therapies. Materials and methods To prioritize targets for drug development, we studied CF remodeling upon activation at transcriptomic and proteomic levels, using three different cell sources: primary adult CF (aHCF), primary fetal CF (fHCF), and induced pluripotent stem cells derived CF (hiPSC-CF). Results All cell sources showed a convergent response upon activation, with clear morphological and molecular remodeling associated with cell-cell and cell-matrix interactions. Quantitative proteomic analysis identified known cardiac fibrosis markers, such as FN1, CCN2, and Serpine1, but also revealed targets not previously associated with this condition, including MRC2, IGFBP7, and NT5DC2. Conclusion Exploring such targets to modulate CF phenotype represents a valuable opportunity for development of anti-fibrotic therapies. Also, we demonstrate that hiPSC-CF is a suitable cell source for preclinical research, displaying significantly lower basal activation level relative to primary cells, while being able to elicit a convergent response upon stimuli.