Miracle-dz/UniFAR-FTUs huggingface dataset:
Study of 
N(1440)
 structure via 
γ*p→N(1440)
 transition

A. Kaewsnod, ∗ K. Xu, Z. Zhao, X. Y. Liu, 2 S. Srisuphaphon, A. Limphirat, and Y. Yan † School of Physics and Center of Excellence in High Energy Physics and Astrophysics, Suranaree University of Technology, Nakhon Ratchasima 30000, Thailand School of Physics, Liaoning University, Shenyang 110036, China Department of Physics, Faculty of Science, Burapha University, Chonburi 20131, Thailand (Dated: June 22, 2021)
The role of AGN and its obscuration on the position of the host galaxy relative to Main Sequence

We use X-ray Active Galactic Nuclei (AGN) observed by the Chandra X-ray Observatory within the 9.3 deg$^2$ Bo$\rm \ddot{o}$tes field of the NDWFS to study whether there is a correlation between X-ray luminosity (L$_X$) and star formation rate (SFR) of the host galaxy, at $\rm 0.5<z<2.0$, with respect to the position of the galaxy to the main sequence (SFR$_{norm}$). About half of the sources in the X-ray sample have spectroscopic redshifts. We also construct a reference galaxy catalogue. For both datasets, we use photometric data from optical to the far infrared, compiled by the HELP project and apply spectral energy distribution (SED) fitting, using the X-CIGALE code. We exclude quiescent sources from both the X-ray and the reference samples. We also account for the mass completeness of our dataset, in different redshifts bins. Our analysis highlights the importance of studying the SFR-L$_X$ relation, in a uniform manner, taking into account the systematics and selection effects. Our results suggest that, in less massive galaxies ($\rm log\,[M_*(M_\odot)] \sim 11$), AGN enhances the SFR of the host galaxy by $\sim 50\%$ compared to non AGN systems. A flat relation is observed for the most massive galaxies. SFR$_{norm}$ does not evolve with redshift. The results, although tentative, are consistent with a scenario in which, in less massive systems, both AGN and star formation (SF) are fed by cold gas, supplied by a merger event. In more massive galaxies, the flat relation could be explained by a different SMBH fuelling mechanism that is decoupled from the star formation of the host galaxy (e.g. hot diffuse gas). Finally, we compare the host galaxy properties of X-ray absorbed and unabsorbed sources. Our results show no difference which suggests that X-ray absorption is not linked with the properties of the galaxy.
Explicit Interaction Network for Aspect Sentiment Triplet Extraction

Aspect Sentiment Triplet Extraction (ASTE) aims to recognize targets, their sentiment polarities and opinions explaining the sentiment from a sentence. ASTE could be naturally divided into 3 atom subtasks, namely target detection, opinion detection and sentiment classification. We argue that the proper subtask combination, compositional feature extraction for target-opinion pairs, and interaction between subtasks would be the key to success. Prior work, however, may fail on `one-to-many' or `many-to-one' situations or derive non-existent sentiment triplets due to defective subtask formulation, sub-optimal feature representation or the lack of subtask interaction. In this paper, we divide ASTE into target-opinion joint detection and sentiment classification subtasks, which is in line with human cognition, and correspondingly utilize sequence encoder and table encoder to handle them. Table encoder extracts sentiment at token-pair level, so that the compositional feature between targets and opinions can be easily captured. To establish explicit interaction between subtasks, we utilize the table representation to guide the sequence encoding, and inject the sequence features back into the table encoder. Experiments show that our model outperforms state-of-the-art methods on six popular ASTE datasets.
COVID‐19 and food prices in sub‐Saharan Africa

Abstract This study investigated the impact of the novel coronavirus disease 2019 (COVID‐19) outbreak on prices of maize, sorghum, imported rice and local rice in sub‐Saharan Africa (SSA). We estimated dynamic panel data models with controls for macroeconomic setting using general method of moments estimation. The study found that the COVID‐19 outbreak led to increases in food prices of the sampled countries. Restrictions on movements or lockdowns in the wake of COVID‐19 was associated with an increase in the price of maize only. We also found that exchange rate, inflation and crude oil prices exerted a detrimental effect on food prices. We recommend that governments of SSA countries invest in infrastructure that improves efficiencies in the food supply chain during pandemics. Providing adequate support to industries in the value chain will also improve food availability and food price stability post‐COVID‐19.
Efficacy of Daratumumab-Based Regimens Compared to Standard of Care in Transplant-Eligible Multiple Myeloma: A Meta-Analysis

Daratumumab (dara) belongs to a class of monoclonal antibodies that target CD38 receptors expressed on multiple myeloma (MM) cells. It was first approved for MM treatment in 2015. The efficacy and safety of dara have been reported in many studies. In this analysis, we assessed the outcome of dara addition to standard of care for transplant-eligible newly diagnosed (ND) MM. We conducted a comprehensive search using PubMed, ClinicalTrial.gov, and Embase. Out of 435 articles, we included two randomized clinical trials. We computed the odds ratio (OR) of response rates and risk ratio (RR) of adverse effects using Cochrane RevMan version 5.4. A total of 1,292 patients were enrolled in both trials. The patients were randomized into the control group and the dara group. The dara group included 647 patients and the control group included 645 patients. The CASSIOPEIA trial reported the outcomes using dara, bortezomib (V), thalidomide (T), and dexamethasone (d) versus VTd. The GRIFFIN trial underlined the efficacy of dara, lenalidomide (R), and Vd in the dara group versus RVd in the control group. A pooled analysis of included studies showed an increased overall response rate (OR: 1.60; 95% CI: 1.06-2.41; p = 0.02; I2 = 65%), stringent complete response (OR: 1.59; 95% CI: 1.24-2.05; p = 0.03; I2 = 0%), and negative status for minimal residual disease (OR: 2.47; 95% CI: 1.97-3.10; p < 0.01; I2 = 66%) in the dara group as compared to the control group. However, an increased risk of neutropenia (RR: 1.80; 95% CI: 1.60-2.03; p < 0.01) and decreased risk of peripheral neuropathy (RR: 0.92; 95% CI: 0.86-0.99; p = 0.02; I2 = 52%) were observed in the dara group. Dara addition to the standard of care regimen for transplant-eligible NDMM has promising outcomes with increased efficacy and safety profile and manageable toxicity.
Overall Survival in Patients With Resected Glioblastoma Treated With Adjuvant Therapy: A Retrospective Study in a Public Hospital in Chile

Glioblastoma (GB) is the most frequent and aggressive primary tumor of the central nervous system (CNS) in adults. Standard treatment is complete tumor resection followed by concomitant radiochemotherapy (RCT) and subsequent adjuvant temozolomide (TMZ). Information about brain tumors statistics in Latin American countries is scarce, so we aimed to measure the overall survival (OS) of patients with resected GB in a single institution in Chile. This is a retrospective report of 67 patients treated between 2012 and 2019 with resected GB and who received adjuvant treatment with radiotherapy (RT) with and without TMZ during 2012-2019 in this center (Chilean NCI). Most of them were men (72%), ages > 50 years old (57%), with Karnofsky performance status (KPS) scale ≥ 70% (94%) and recursive partitioning analysis-IV (RPA-IV) (60%). Some 54% received concomitant TMZ and RT. Median OS was 11.4 months, with 1-, 2-, and 5-year OS of 48%,15%, and 3% respectively. In conclusion, in patients with GB treated with RCT at the NCI, OS was the same as expected from international articles. Adjuvant RCT therefore is considered the standard of care at NCI.
Ju l 2 01 4 AN EXTENSION OF HSIUNG-MINKOWSKI FORMULAS AND SOME APPLICATIONS

There has been a number of results in the literature on Minkowskitype formulas, which relate the integrals of different (weighted) k-th mean curvatures for closed oriented hypersurfaces or submanifolds in a Riemannian manifold (see e.g. [2, 7, 13, 24, 27]), under various assumptions. As a typical example, let us recall the classical HsiungMinkowski formulas [13]: if (M, g) is a space form and Σ is a closed oriented hypersurface in M with a unit normal vector field ν, suppose M possesses a conformal vector field X , i.e. the Lie derivative of g satisfies LXg = 2αg for some function α, then we have
Building QA Robustness Through Data Augmentation

While question and answering (QA) models have achieved tremendous results on in-domain queries, recent research has brought into question the ability of these QA models to generalize well to unseen data in other domains. As such, we aim to build a robust question answering system, which trained on a set of in-domain data can then be adapted to unseen domains given few training samples. In doing so, we explore the field of data augmentation. In this work, we conduct a survey of existing data augmentation methods, including backtranslation, synonym replacement, and synonym insertion as well as introduce a mixed data augmentation method (MDA) combining the previous three. In particular, we explore the efficacy of data augmentation in the task of question answering. We find that data augmentation provides moderate gains on our out of domain validation and test sets and that certain methods such as backtranslation and synonym replacement provide larger improvements compared to others. Overall, we confirm that data augmentation is a simple, generalizable technique with a wide variety of different methods that can effectively aid in improving the robustness of QA models in the face of unseen domains with few training examples.
Oculomotor behaviours and integrative memory functions in the Alzheimer’s Clinical Syndrome

Background. Biological information drawn from eye-tracking metrics is providing evidence regarding drivers of cognitive decline in Alzheimer disease. In particular, pupil size has proved useful to investigate cognitive performance during online activities. Objective. To investigate the oculomotor correlates of impaired performance of patients with mild Alzheimer’s Clinical Syndrome (ACS) on a recently developed memory paradigm, namely the Short-Term Memory Binding Test (STMBT). Methods. We assessed a sample of eighteen healthy controls (HC) and eighteen patients with a diagnosis of mild ACS with the STMBT while we recorded their oculomotor behaviours using pupillometry and eye-tracking. The STMBT assessed the ability to detected changes across two consecutive visual arrays, study and test, presenting 2 bicolored objects. In one condition, changes consisted of new colours in test objects replacing colours presented in the study objects (i.e., Unbound Colours - UC). In the other condition, changes consisted of two studied colours swapping between objects at test (i.e., Bound Colours - BC). We assessed recognition of such changes. Results. As expected, a group (healthy controls vs Alzheimer’s Clinical Syndrome) by condition (Unbound Colours vs Bound Colours) interaction was found whereby behavioural group differences were paramount in the Bound Colours condition. Healthy control’s pupil dilated significantly more in the Bound Colours than in the Unbound Colours condition, discrepancy not observed in Alzheimer’s Clinical Syndrome patients. Furthermore, ROC analysis revealed the abnormal pupil behaviours distinguished Alzheimer’s Clinical Syndrome patients from healthy controls with values of sensitivity and specify of 100%, thus outperforming both recognition scores and gaze duration. Conclusions . The biological correlates of Short-Term Memory Binding impairments appear to involve a network much wider than we have thought to date, which expands across cortical and subcortical structures. We discuss these findings focusing on their implications for our understanding of neurocognitive phenotypes in the preclinical stages of Alzheimer Disease and potential development of cognitive biomarkers that can support ongoing initiatives to prevent dementia. 1 presents (a) pupil size data across Memory Stages (Encoding vs. Retrieval) and Task conditions (BC and UC) as function of % of correct recognition. It also presents outcomes from the statistical comparisons including (b) interactions of Condition x Group, and (c) interactions of Condition x Group x Memory Stages.
Primary care use by men with symptoms of possible prostate cancer: A multi-method study with an ethnically diverse sample in London.

OBJECTIVE The objective of this study is to investigate primary care use by men with recent onset of lower urinary tract symptoms (LUTS) to identify differences in presentation and investigation that may explain ethnic inequality in prostate cancer outcomes. METHODS This is a multi-method study of men presenting LUTS to primary care. Two hundred seventy-four men completed a self-administered questionnaire, and 23 participated in face-to-face interviews. Regression analyses investigated ethnic differences in (a) the period between symptom onset and first primary care presentation (patient interval) and (b) the interval between first primary care presentation and investigation with prostate-specific antigen (PSA) and digital rectal examination (DRE). Interview data were analysed using thematic analysis. RESULTS Half (144, 53%) reported a solitary first symptom, although multiple first symptoms were also common, particularly in Asian and Black men. There was no difference between ethnicities in patient interval or time from presentation to investigation. However, Asian men were offered less PSA testing (odds ratio 0.39; 95% confidence interval 0.17-0.92; p = 0.03). Qualitative data revealed ethnic differences in general practitioners' offer of DRE and PSA testing and highlighted limitations in doctor-patient communication and safety netting. CONCLUSION Our study showed only small differences in primary care experiences, insufficient to explain ethnic inequalities in prostate cancer outcomes.
Perspectives on returning to work of multiple myeloma patients: A qualitative interview study

Abstract Objective Multiple myeloma (MM) is a rare and incurable disease. Because new treatments improved survival rates, return to work (RTW) became more relevant to MM patients of working age. Also, (health care) experts may be confronted with specific obstacles in guiding MM patients' RTW. Therefore, we aimed to qualitatively explore perspectives and experiences of MM patients and (health care) experts regarding RTW and participation at work. Methods Semi‐structured interviews were conducted with patients (N = 9) and (health care) experts (N = 15). Interviews were transcribed verbatim and analysed using thematic analysis. Results Four themes resulted from the interviews with patients and (health care) experts: (1) severity of diagnosis and treatment impact RTW, (2) step‐by‐step reintegration facilitates RTW, (3) meaning of work differs between MM patients and experts and (4) lack of tailored counselling by experts. Conclusion Although MM patients' work ability may be limited due to the severity of diagnosis and side effects from treatment, most patients consider RTW important. Both patients and (health care) experts emphasise the benefits from early work ability assessment (in the hospital setting) and specialised RTW counselling, especially in those with physically demanding jobs.
The short- and long-term efficacies of endovascular interventions for the treatment of acute ischemic stroke patients.

OBJECTIVE We aimed to investigate the short- and long-term efficacies of endovascular interventional therapy in acute ischemic stroke (AIS) patients. METHODS In this retrospective study, 94 patients with AIS were recruited and divided into a control group (n=51) that was administered intra-arterial thrombolysis and an observation group (n=43) that was administered Solitaire stent thrombectomies. The postoperative recanalization and overall response rates were recorded in both groups. The hemodynamic parameters (high shear viscosity, low shear viscosity, plasma viscosity, and hematocrit), and the C-reactive protein, interleukin 6, and fibrinogen levels were compared between the two groups before and after the treatment. In addition, the National Institutes of Health Stroke Scale and the modified Rankin Scale scores were analyzed before the treatment and at 1 and 3 months after the treatment in both groups. After a 3-year follow-up, a survival analysis was also performed using the Kaplan-Meier survival method. RESULTS The overall response and recanalization rates were higher in the observation group than they were in the control group (P<0.05). Before the treatment, there were no significant differences in the hemodynamic parameter, C-reactive protein, interleukin, 6 and fibrinogen levels in the two groups (P>0.05). After the treatment, the above levels in both groups decreased compared to their levels before the treatment, and the observation group had significantly lower levels than the control group (P<0.05). Moreover, no significant differences were seen in National Institutes of Health Stroke Scale and modified Rankin Scale scores between the two groups before the treatment (P>0.05). After the treatment, the above scores were decreased in both groups at 1 and 3 months compared to their pre-treatment levels, and the scores were significantly lower in the observation group than they were in the control group at 1 month after the treatment (P<0.05). After a 3-year follow-up, the Kaplan-Meier survival curves demonstrated that the survival times were significantly longer in the observation group than they were in the control group (P<0.05). CONCLUSION Solitaire stent thrombectomy markedly ameliorates neurological deficits in AIS patients, improves their recanalization rated, regulates the inflammatory response and hemodynamics in the lesion areas, thus exerting favorable short- and long-term clinical effects.
Prevalence, service use and clinical correlates of hallucinations and delusions in an out-patient population from India

Abstract Background Despite the persistent public health problem of positive psychotic symptoms, understanding of symptom specific prevalence rates, clinical correlates and service utilisation are sparse. Aims The current study aimed to establish prevalence, clinical and service utilisation correlates of hallucinations and delusions in people accessing outpatient clinics in Tamil Nadu, India. Methods Secondary patient data from outpatient clinics, over a 12-month period, in 2016, was used for analysis (N = 917). Based on the presence of positive psychotic symptoms (PPSx), the sample was divided into four groups for analysis- hallucinations-only (H), delusions-only (D), both hallucinations and delusions (HD) and neither PPSx (N-PPSx). Results Findings indicate that the most prevalent PPSx were hallucinations (10.7%) however, barriers to service utilisation and clinical correlates were associated predominantly with the D and the HD group; as was severe work impairment. Yet, this group was most likely to remain with psychiatric services. Lastly, diagnostic challenges were apparent within the sample. Conclusions The study revealed that despite more barriers to service utilisation, persons with PPSx remain in contact with services. Yet prognosis remains only moderate at best, indicating other mediating and underlying factors impeding recovery may be interplaying and, therefore, a need for enhanced biopsychosocial approaches.
External Validation of a Widely Implemented Proprietary Sepsis Prediction Model in Hospitalized Patients.

Importance The Epic Sepsis Model (ESM), a proprietary sepsis prediction model, is implemented at hundreds of US hospitals. The ESM's ability to identify patients with sepsis has not been adequately evaluated despite widespread use. Objective To externally validate the ESM in the prediction of sepsis and evaluate its potential clinical value compared with usual care. Design, Setting, and Participants This retrospective cohort study was conducted among 27 697 patients aged 18 years or older admitted to Michigan Medicine, the academic health system of the University of Michigan, Ann Arbor, with 38 455 hospitalizations between December 6, 2018, and October 20, 2019. Exposure The ESM score, calculated every 15 minutes. Main Outcomes and Measures Sepsis, as defined by a composite of (1) the Centers for Disease Control and Prevention surveillance criteria and (2) International Statistical Classification of Diseases and Related Health Problems, Tenth Revision diagnostic codes accompanied by 2 systemic inflammatory response syndrome criteria and 1 organ dysfunction criterion within 6 hours of one another. Model discrimination was assessed using the area under the receiver operating characteristic curve at the hospitalization level and with prediction horizons of 4, 8, 12, and 24 hours. Model calibration was evaluated with calibration plots. The potential clinical benefit associated with the ESM was assessed by evaluating the added benefit of the ESM score compared with contemporary clinical practice (based on timely administration of antibiotics). Alert fatigue was evaluated by comparing the clinical value of different alerting strategies. Results We identified 27 697 patients who had 38 455 hospitalizations (21 904 women [57%]; median age, 56 years [interquartile range, 35-69 years]) meeting inclusion criteria, of whom sepsis occurred in 2552 (7%). The ESM had a hospitalization-level area under the receiver operating characteristic curve of 0.63 (95% CI, 0.62-0.64). The ESM identified 183 of 2552 patients with sepsis (7%) who did not receive timely administration of antibiotics, highlighting the low sensitivity of the ESM in comparison with contemporary clinical practice. The ESM also did not identify 1709 patients with sepsis (67%) despite generating alerts for an ESM score of 6 or higher for 6971 of all 38 455 hospitalized patients (18%), thus creating a large burden of alert fatigue. Conclusions and Relevance This external validation cohort study suggests that the ESM has poor discrimination and calibration in predicting the onset of sepsis. The widespread adoption of the ESM despite its poor performance raises fundamental concerns about sepsis management on a national level.
The Effects of Static Stretching On Dynamic Postural Control During Maximum Forward Leaning Task

Abstract The purpose of this study was to determine how the application of static stretching to ankle plantar flexors affects postural control during maximum forward leaning. Twenty-six volunteer males (age 21.4 ± 1.2 years) were randomly assigned to stretching and control conditions. Participants conducted 5-min stretching on a stretch board for the stretching condition and were kept standing for 6-min for the control condition. Before and after intervention, the range of motion (ROM) at ankle dorsiflexion and the center of pressure (COP) excursion during maximal forward leaning were determined. Mean anteroposterior COP position, COP velocity and COP areas were calculated to compare the change in postural control. After stretching, ROM was significantly increased. During maximal forward leaning after stretching, both COP position and velocity showed significant increases compared to before stretching. Moreover, COP position and velocity in the stretching condition were significantly higher than in the control condition after stretching. No significant differences were found in COP area before and after stretching. Five-minute stretching increased not only ROM but also the anterior limit of stability while maintaining posture and led to faster COP shift than before stretching. These results indicate that static stretching would improve dynamic postural control as well.