Miracle-dz/UniFAR-FTUs huggingface dataset:
ATOMS (Adjustable Trans-Obturator Male System) in Patients with Post-Prostatectomy Incontinence and Previously Treated Urethral Stricture or Bladder Neck Contracture

(1) Background: Male stress incontinence in patients with previously treated urethral or bladder neck stricture is a therapeutic challenge. The efficacy and safety of the adjustable trans-obturator male system (ATOMS) in these patients is unknown. (2) Methods: All patients with primary ATOMS implants in our institution between 2014 and 2021 were included. The outcomes of patients with previously treated urethral or bladder neck stricture (≥6 months before ATOMS implant) and stable 16Ch urethral caliber were compared to those without a history of stricture. The primary endpoint was the dry patient rate, defined as the pad test ≤ 20 mL/day, and complication rate, including device removal. The secondary variable was self-perceived satisfaction using the Patient Global Impression of Improvement (PGI-I) scale. Wilcoxon rank sum test, Fisher’s exact test and logistic regression were performed. (3) Results: One hundred and forty-nine consecutive patients were included, twenty-one (14%) previously treated for urethral or bladder neck stricture (seven urethroplasty, nine internal urethrotomy and five bladder neck incision). After ATOMS adjustment, 38% of the patients with treated stricture were continent compared to 83% of those without (p < 0.0001). After weighted matched observations using propensity score pairing, the proportion of continent patients without a previous stricture was 56% (p = 0.236). Complications occurred in 29% of the patients with stricture and in 20% of those without (p = 0.34). The severity of the complications was distributed evenly among the groups (p = 0.42). Regarding self-perceived satisfaction with the implant, 90% of the patients with stricture perceived the results satisfactorily (PGI-I 1–3) compared to 97% of the rest (p = 0.167). Stricture was associated with radiotherapy (p < 0.0001) and time from prostatectomy to implantation (p = 0.012). There was a moderate correlation between previous stricture and the severity of incontinence, both evaluated according to the 24-h pad test (Rho = 0.378; p < 0.0001) and the ICIQ-SF questionnaire (Rho = 0.351; p < 0.0001). Multivariate analysis for the factors predictive of failure after ATOMS adjustment revealed previous stricture (OR 4.66; 95% CI 1.2–18.87), baseline 24-h pad test (per 100 mL, OR 1.28; 95% CI 1.09–1.52) and final cushion volume (per mL, OR 1.34; 95% CI 1.19–1.55). This model predicted dryness with an AUC of 92%. After the PSMATCH procedure using a propensity score, the model remained unchanged, with the previous stricture (OR 8.05; 95% CI 1.08–110.83), baseline 24-h pad test (per 100 mL, OR 1.53; 95% CI 1.15–2.26) and final cushion volume (per mL, OR 1.45; 95% CI 1.17–2) being independent predictors and an AUC of 93%. (4) Conclusions: ATOMS can be used to treat male stress incontinence in patients with a history of stricture, although the effectiveness of the device is reduced. On the other hand, the security and perceived satisfaction were equivalent for both groups.
Sequential expression of miR-221-3p and miR-338-3p in Schwann cells as a therapeutic strategy to promote nerve regeneration and functional recovery

The functional properties of endogenous Schwann cells (SCs) during nerve repair are dynamic. Optimizing the functional properties of SCs at different stages of nerve repair may have therapeutic benefit in improving the repair of damaged nerves. Previous studies showed that miR-221-3p promotes the proliferation and migration of SCs, and miR-338-3p promotes the myelination of SCs. In this study, we established rat models of sciatic nerve injury by bridging the transected sciatic nerve with a silicone tube. We injected a miR-221 lentiviral vector system together with a doxycycline-inducible Tet-On miR-338 lentiviral vector system into the cavity of nerve conduits of nerve stumps to sequentially regulate the biological function of endogenous SCs at different stages of nerve regeneration. We found that the biological function of SCs was sequentially regulated, the diameter and density of myelinated axons were increased, the expression levels of NF200 and myelin basic protein were increased, and the function of injured peripheral nerve was improved using this system. miRNA Target Prediction Database prediction, Nanopore whole transcriptome sequencing, quantitative PCR, and dual luciferase reporter gene assay results predicted and verified Cdkn1b and Nrp1 as target genes of miR-221-3p and miR-338-3p, respectively, and their regulatory effects on SCs were confirmed in vitro. In conclusion, here we established a new method to enhance nerve regeneration through sequential regulation of biological functions of endogenous SCs, which establishes a new concept and model for the treatment of peripheral nerve injury. The findings from this study will provide direct guiding significance for clinical treatment of sciatic nerve injury.
Vorticity and Incompressible Flow: Index

This book is a comprehensive introduction to the mathematical theory of vorticity and incompressible flow ranging from elementary introductory material to current research topics. Although the contents center on mathematical theory, many parts of the book showcase the interactions among rigorous mathematical theory, numerical, asymptotic, and qualitative simplified modeling, and physical phenomena. The first half forms an introductory graduate course on vorticity and incompressible flow. The second half comprises a modern applied mathematics graduate course on the weak solution theory for incompressible flow.
How Metagenomics Has Transformed Our Understanding of Bacteriophages in Microbiome Research

The microbiome is an essential part of most ecosystems. It was originally studied mostly through culturing but relatively few microbes can be cultured, so much of the microbiome was left unexplored. The emergence of metagenomic sequencing techniques changed that and allowed the study of microbiomes from all sorts of habitats. Metagenomic sequencing also allowed for a more thorough exploration of prophages, viruses that integrate into bacterial genomes, and how they benefit their hosts. One issue with using open-access metagenomic data is that sequences added to databases often have little to no metadata to work with, so finding enough sequences can be difficult. Many metagenomes have been manually curated but this is a time-consuming process and relies heavily on the uploader to be accurate and thorough when filling in metadata fields and the curators to be working with the same ontologies. Using algorithms to automatically sort metagenomes based on either the taxonomic profile or the functional profile may be a viable solution to the issues with manually curated metagenomes, but it requires that the algorithm is trained on carefully curated datasets and using the most informative profile possible in order to minimize errors.
Spillover Effects of Recruiting Teachers for School Turnaround: Evidence From Tennessee

Many districts and states have implemented incentives to recruit teachers to low-performing schools, and previous research has found evidence that these incentives are effective at attracting teachers. However, effects on the schools and students these teachers leave behind have not been examined. This study focuses on the spillover effects of recruiting effective teachers to Tennessee’s Innovation Zone (iZone) schools. We find the short-term effects of losing these teachers range from −0.04 to −0.12 SDs in student test score gains, with larger negative effects when more effective teachers leave. However, combining both these negative effects in schools teachers leave and the positive effects in iZone schools yields overall net positive effects.
The Personal Pronouns of The Mehri Language as Spoken in Saudi Arabia

Mehri is one of six Modern South Arabian languages spoken in southern Arabia. These languages have been noted for their retention of Semitic phonological and grammatical features that have disappeared from other Semitic languages. Mehri is spoken in Oman, Yemen, in parts of southern and eastern Saudi Arabia, and in some of Gulf States. Mehri is classified by UNESCO as “definitely endangered”. Previous studies of Omani and Yemeni Mehri exist, but there have been no studies on Mehri that are used in Saudi Arabia. Morphologically, the dialect groups of Mehri differ in that eastern Yemeni Mehri, also known as Mahriyōt, distinguishes gender in the second person singular independent pronouns, whereas Omani Mehri, Mehreyyet, and western Yemeni Mehri do not. However, Mahriyōt and Mehreyyet differ from western Yemeni Mehri in that they exhibit dual pronouns and dual verb inflections. This study examines number/gender marking in the dependent and independent pronouns of the Mehri spoken in Dammam in the eastern region of Saudi Arabia. Twelve hours of recordings were made during interviewing eleven Mehri speakers (seven males and 4 females) who are living in Dammam. Some of the informants were born in Dammam and others had moved there in different years.
Risk Factors for Intimate Partner Femicide–Suicide in Italy: An Ecological Approach

The present study investigated the intimate partner femicide (IPF) and intimate partner femicide–suicide (IPFS) perpetrators’ individual, relational, and contextual characteristics by analyzing, within the ecological approach, femicide cases that occurred in Italy from 2010 to 2019. On the topic, to date, scant studies examined possible differences between IPF and IPFS risk factors, and no studies have analyzed these factors by adopting an ecological systems model perspective. To this aim, archival research was carried out. Of a total of 1.207 femicides, 409 were IPF, and 227 were IPFS. Perpetrators’ age, level of employment, law enforcement membership, mental and/or physical illnesses, use of psychoactive substances, previous crimes, previous violent relationships, presence of children, previous violence in the couple, inability to accept the end of the relationship, quarrels and conflict, jealousy and the psychophysical illnesses of both authors and victims, as well as the use of firearms and victim’s request for help were analyzed. The results underlined the existence of different risk factors contributing to the IPF perpetrators’ decision to commit suicide such as perpetrators’ age, law enforcement membership, and firearm availability. These findings stress the need for specific risk assessment and management strategies for IPFS perpetrators.
Protein Supplementation as a Nutritional Strategy to Reduce Gastrointestinal Nematodiasis in Periparturient and Lactating Pelibuey Ewes in a Tropical Environment

The study was carried out to evaluate the effect of energy and protein supplementation on parasitological and hematological response during peripartum and lactation of productive and non-productive Pelibuey ewes in a tropical environment. Forty-eight Pelibuey ewes aged 3–5 years and with a body weight of 31 ± 5 kg were used. Four groups of 12 ewes, including non-pregnant and productive ewes, were formed. A factorial treatment design was formulated, where two levels of energy (low, 9.6 MJ/kg, n = 24; and high, 10.1 MJ/kg, n = 24) and two levels of protein (high, 15% crude protein in diet, n = 24; and low, 8% crude protein in diet, n = 24) were studied. Fecal and blood samples were collected to determine the fecal egg count (FEC) of gastrointestinal nematodes (GIN), packed cell volume (PCV) and peripheral eosinophil (EOS) count. These variables were rearranged with respect to the lambing date in a retrospective study. The high dietary protein level had a significant effect on reducing the FEC and increasing the PCV of ewes during lactation, in comparison with animals fed with the low protein level. Differences in the study variables were attributed to physiological stage. Lactating ewes showed the highest FEC values (2709 ± 359 EPG), the lowest PCV values (21.9 ± 0.7%) and the lowest EOS (0.59 ± 0.6 Cells × 103 µL). It is concluded that high levels of dietary protein improve the hematological response and reduce the FEC in Pelibuey ewes under grazing conditions. The non-pregnant ewes maintained some resilience and resistance to GIN infection compared to productive ewes.
Attitudes towards the death penalty: An assessment of individual and country-level differences

Research on public attitudes to the death penalty has been predominantly understood through single nation-states, especially within the USA. Examinations of international differences in citizens’ support for the death penalty have been scarce, particularly among continents with a high volume of retentionist nations (e.g. Asia). In this paper, we draw on a dataset of 135,000 people from across 81 nations to examine differences in death penalty support. We find that residents of retentionist nations are generally more supportive of the death penalty than those from abolitionist nations. But this general difference masks important differences both within and between countries. At the country-level, residents of abolitionist nations with autocratic political systems and those with higher homicide levels were more likely to support the death penalty than residents of other abolitionist nations. At the individual level, greater support for a strong dictatorial-type leader and perceptions of political corruption are associated with increased support for the death penalty, but only in abolitionist nations. By contrast, more frequent religious worship, perceived egalitarianism in a nation, and support for the political performance of government reduced death penalty support in abolitionist nations but increased support in retentionist nations, while belief in individual responsibility and critical views towards ethnic minorities increased support for the death penalty across both abolitionist and retentionist nations.
Determinants of Suicide Ideation in the Romanian Population

Background: Suicide ideation and behaviors are directly linked to the risk of death by suicide. In Romania, as well as worldwide, increased suicide rates were observed in the recent past, more so in the context of the COVID-19 pandemic. The purpose of this study was to investigate the influence of psychosocial factors, quality of life (QOL), and loneliness dimensions and adverse life antecedents on suicide ideation (SI) and prolonged sadness (PS). Methods: This cross-sectional quantitative research study used a CATI data gathering method to investigate 1102 randomly selected individuals over 18 years of age regarding various determinants of SI and PS. Data were collected in June 2021. Descriptive, inferential, and multivariate statistics were used for data analysis. Results: SI was negatively correlated with all the assessed psychosocial factors, more significantly with family relationships, wealth, health, social relationships, and affective life. Stronger correlations were observed when investigating the state of prolonged sadness, sex, and affective lives along with health and income, which were more influential. SI was negatively correlated with QOL and positively correlated with adverse life events and total loneliness scores. Lesser educated youngsters with reduced overall happiness and a history of depression, self-harm, and trauma were at greater risk of developing SI. Conclusions: This is the first national study exploring the suicide ideation and prolonged sadness in relation to psychosocial factors, quality of life, and adverse life events. These results have important implications for suicide prevention programs, which should be designed in accordance with similar studies.
The Verbal Phrase in Paraguayan Guarani: A Case Study on the Role of Prosody in Linearization

This paper examines in detail the morpho-syntax of the verbal phrase in Paraguayan Guarani, in root and complement clauses, and argues that while the ordering relation between the verb and its associated functional morphemes is congruent with the syntax (cf. the Mirror Principle), the ordering of post-verbal arguments is best understood in terms of phonological linearization. More specifically, it is argued that there are language-particular prosodic requirements that force the post-verbal arguments to be phonologically linearized outside the accentual domain defined by the verb and its associated functional morphemes.
Compressive Strength Properties Perpendicular to the Grain of Hollow Glue-Laminated Timber Elements

Timber is one of the fundamental materials of human civilization, it is very useful and ecologically acceptable in its natural environment, and it fits very well with modern trends in green construction. The paper presents innovative hollow glued laminated (GL) timber elements intended for log-house construction. Due to the lack of data on the behavior of the hollow timber section in compression perpendicular to the grain, the paper presented involves testing the compression strength of elliptical hollow cross-section glue-laminated timber specimens made of softwood and hardwood, as well as full cross-section glue-laminated softwood timber specimens. The experimental research was carried out on a total of 120 specimens. With the maximal reduction of 26% compared to the full cross-section, regardless of the type of wood and direction of load, the compression strength perpendicular to the grain of hollow specimens decreases by about 55% compared to the full cross-section, with the coefficient kc,90 equal to 1.0. For load actions at the edge and the middle of the element, kc,90 factors were obtained with a value closer to those obtained for full cross-section, which indicates the same phenomenology, regardless of cross-sectional weakening. At the same time, the factors in the stronger axis are lower by about 10%, and in the weaker axis by about 30% compared to those prescribed by the Eurocode. Experimental research was confirmed by FEM analysis. Comparative finite element analysis was performed in order to provide recommendations for future research and, consequently, to determine the optimal cross-section form of the hollow GL timber element. By removing the holes in the central part of the cross-section, the stress is reduced. The distance of the holes from the edges defines the local cracking. Finally, if the holes are present only in the central part of the element, the behavior of the element is more favorable.
Perspectives in analysis, geometry, and topology : on the occasion of the 60th birthday of Oleg Viro

Preface. - 1 Selman Akbulut, Exotic structures on smooth 4-manifolds. - 2 Kenneth Baker, John Etnyre, Rational linking and contact geometry. - 3 Robert Berman, Jean-Pierre Demailly, Regularity of plurisubharmonic upper envelopes in big cohomology classes. - 4 Alex Degtarev, Towards the generalized Shapiro and Shapiro conjecture. -5 Alex Degtarev, Ilia Itenberg, Viatcheslav Kharlamov, On the number of components of a complete intersection of real quadrics. - 6 Tobias Ekholm, Rational Symplectic Field Theory and linearized Legendrian contact homology. - 7 Yakov Eliashberg, N. Mishachev, Wrinkling IV: Mappings with prescribed singularities. - 8 Michael Entov, Leonid Polterovich, Pierre Py, On continuity of quasimorphisms for symplectic maps. With an appendix by Michael Khanevsky. - 9 David Gay, Andras Stipsicz, On symplectic caps. - 10 Gennadi Henkin, Cauchy-Pompeiu type formulas for a on affine algebraic Riemann surfaces and some applications. -11 Kiumars Kaveh, A. G. Khovanskii, Algebraic equations and convex bodies. - 12 Louis Kauffman, Graphical Bracket Invariants of Virtual Links. - 13 Ciprian Manolescu, Christopher Woodward, Floer homology on the extended moduli space. - 14 Ngaiming Mok, Projective-algebraicity of minimal compactifications of complex-hyperbolic space forms of finite volume. - 15 Stepan Orevkov, Some examples of real algebraic and real pseudoholomorphic curves. - 16 Nicolai Reshetikhin, Topological invariants related to quantum groups at roots of unity. - 17 Alexander Shumakovitch: Khovanov Homology Theories and Their Applications. - 18 Eugenii Shustin, Patchworking theorem for tropical curves with multiple points.
Cyclophilin A/CD147 Interaction: A Promising Target for Anticancer Therapy

Cyclophilin A (CypA), which has peptidyl–prolyl cis-trans isomerase (PPIase) activity, regulates multiple functions of cells by binding to its extracellular receptor CD147. The CypA/CD147 interaction plays a crucial role in the progression of several diseases, including inflammatory diseases, coronavirus infection, and cancer, by activating CD147-mediated intracellular downstream signaling pathways. Many studies have identified CypA and CD147 as potential therapeutic targets for cancer. Their overexpression promotes growth, metastasis, therapeutic resistance, and the stem-like properties of cancer cells and is related to the poor prognosis of patients with cancer. This review aims to understand the biology and interaction of CypA and CD147 and to review the roles of the CypA/CD147 interaction in cancer pathology and the therapeutic potential of targeting the CypA/CD147 axis. To validate the clinical significance of the CypA/CD147 interaction, we analyzed the expression levels of PPIA and BSG genes encoding CypA and CD147, respectively, in a wide range of tumor types using The Cancer Genome Atlas (TCGA) database. We observed a significant association between PPIA/BSG overexpression and poor prognosis, such as a low survival rate and high cancer stage, in several tumor types. Furthermore, the expression of PPIA and BSG was positively correlated in many cancers. Therefore, this review supports the hypothesis that targeting the CypA/CD147 interaction may improve treatment outcomes for patients with cancer.
Dual Diagnosis in Adolescents with Problematic Use of Video Games: Beyond Substances

The technological revolution has led to the birth of new diagnoses, such as gaming disorder. When any addiction, including this one, is associated with other mental disorders, it is considered a dual diagnosis. The objectives of this current work were to estimate the prevalence of dual diagnoses in the adolescent general population while also considering the problematic use of video games and substance addiction and assessing its psychosocial risk factors. Thus, we carried out a cross-sectional study with a sample of 397 adolescents; 16.4% presented problematic videogame use and 3% presented a dual diagnosis. Male gender increased the probability of both a dual diagnosis (OR [95% CI] = 7.119 [1.132, 44.785]; p = 0.036) and problematic video game use (OR [95% CI] = 9.85 [4.08, 23.77]; p < 0.001). Regarding personality, low conscientiousness, openness, and agreeableness scores were predictors of a dual diagnosis and problematic videogame use, while emotional stability predicted a dual diagnosis (OR [95% CI] = 1.116 [1.030, 1.209]; p = 0.008). Regarding family dynamics, low affection and communication increased both the probability of a dual diagnosis (OR [95% CI] = 0.927 [0.891, 0.965]; p < 0.001) and problematic video game use (OR [95% CI] = 0.968 [0.945, 0.992]; p = 0.009). Regarding academic performance, bad school grades increased the probability of a dual diagnosis. In summary, male gender, certain personality traits, poor communication, and poor affective family dynamics should be interpreted as red flags that indicate an increased risk of a dual diagnosis in adolescents, which could require early intervention through specific detection programs.