Miracle-dz/UniFAR-FTUs huggingface dataset:
Poor Survival and Differential Impact of Genetic Features of Black Patients with Acute Myeloid Leukemia.

Clinical outcome of patients with acute myeloid leukemia (AML) is associated with cytogenetic and molecular factors and patient demographics (e.g., age and race). We compared survival of 25,523 Non-Hispanic Black and White adults with AML using Surveillance Epidemiology and End Results (SEER) Program data, and performed mutational profiling of 1,339 AML patients treated on frontline Alliance for Clinical Trials in Oncology (Alliance) protocols. Black patients had shorter survival than White patients, both in SEER and in the setting of Alliance clinical trials. The disparity was especially pronounced in Black patients <60 years, after adjustment for socioeconomic (SEER) and molecular (Alliance) factors. Black race was an independent prognosticator of poor survival. Gene mutation profiles showed fewer NPM1 and more IDH2 mutations in younger Black patients. Overall survival of younger Black patients was adversely affected by IDH2 mutations and FLT3-ITD, but, in contrast to White patients, was not improved by NPM1 mutations.
Mineral Trioxide Aggregate-induced AMPK Activation Stimulates Odontoblastic Differentiation of Human Dental Pulp Cells.

AIM To investigate the role of autophagy in MTA-induced odontoblastic differentiation of human dental pulp cells (HDPCs). METHODOLOGY In MTA-treated HDPCs, odontoblastic differentiation was assessed based on expression levels of dentine sialophosphoprotein (DSPP) and dentine matrix protein 1 (DMP1), alkaline phosphatase activity (ALP) activity by ALP staining and the formation of mineralized nodule by Alizarin red S staining. Expression of microtubule-associated protein 1A/1B-light chain3 (LC3), adenosine monophosphate-activated protein kinase (AMPK)/mammalian target of rapamycin (mTOR) signaling molecules and autophagy-related genes, were analyzed by Western blot analysis and Acridine orange staining was used to detect autophagic lysosome. For in vivo experiments, tooth cavity preparation models on rat molars was established and the expression of proteins related odontogenesis and autophagy markers were observed by Immunohistochemistry and Western blot analysis. Kruskal-Wallis with Dunn's multiple comparison was used for statistical analysis. RESULTS MTA promoted odontoblastic differentiation of HDPCs, accompanied by autophagy induction, including formation of autophagic lysosome and cleavage of LC3 to LC3II (P < 0.05). Conversely, inhibition of autophagy through 3MA significantly attenuated the expression level of DSPP (P < 0.05) and DMP1 (P < 0.05) as well as formation of mineralized nodules (P < 0.05), indicating the functional significance of autophagy in MTA-induced odontoblastic differentiation. Also, MTA increased the activity of AMPK (P < 0.01), whereas inhibition of AMPK by compound C downregulated DSPP (P < 0.01) and DMP1 (P < 0.05), but increased the phosphorylation of mTOR (P < 0.05), p70S6 (P < 0.01) and Unc-51-like kinases 1 (ULK1)(ser757) (P < 0.01), explaining the involvement of AMPK pathway in MTA-induced odontoblast differentiation. In vivo study, MTA treatment after tooth cavity preparation on rat molars upregulated DMP-1 and DSPP as well as autophagy-related proteins LC3II and p62, and enhanced the phosphorylation of AMPK. CONCLUSION MTA induced odontoblastic differentiation and mineralization by modulating autophagy with AMPK activation in HDPCs. Autophagy regulation is a new insight on regenerative endodontic therapy using MTA treatment.
Tritordeum Breads are well Tolerated with Preference over Gluten-Free Breads in Non-Celiac Wheat-Sensitive (NCWS) Patients and its Consumption Induce Changes in Gut Bacteria.

BACKGROUND The ingestion of wheat and other cereals are related to several gut disorders. The specific components responsible for NCWS may include gluten and other compounds. Tritordeum is a new cereal derived from crossing durum wheat with a wild barley species, which differs from bread wheat in its gluten composition. In the present work, we examined the response of NCWS patients to tritordeum bread Gastrointestinal symptoms as well as tritordeum acceptability, Gluten Immunogenic Peptides excretion, and the composition and structure of the intestinal microbiota were evaluated. RESULTS Gastrointestinal symptoms of the subjects showed no significant change between the gluten-free bread and the tritordeum bread. Participating subjects rated tritordeum bread higher than the gluten-free bread. Analysis of the bacterial gut microbiota indicated that tritordeum consumption does not alter the global structure and composition of the intestinal microbiota, and only a few changes in some butyrate-producing bacteria were observed. CONCLUSIONS All the results derived from acceptability, biochemical and microbiological tests suggest that tritordeum may be tolerated by a sub-set of NCWS sufferers who do not require strict exclusion of gluten from their diet. This article is protected by copyright. All rights reserved.
Neighborhood racial demographics predict infants' neural responses to people of different races.

Early in life, greater exposure to diverse people can change the tendency to prefer one's own social group. For instance, infants from racially diverse environments show less preference for their own-race (ingroup) over other-race (outgroup) faces than infants from racially homogeneous environments. Yet how social environment changes ingroup versus outgroup demarcation in infancy is unclear. A commonly held assumption is that early emerging ingroup preference is based on an affective process: feeling more comfortable with familiar ingroup than unfamiliar outgroup members. However, other processes may also underlie ingroup preference: Infants may attend more to ingroup than outgroup members and/or mirror the actions of ingroup over outgroup individuals. By aggregating 7- to 12-month-old infants' electroencephalography (EEG) activity across three studies, we disambiguate these different processes in the EEG oscillations of preverbal infants according to social environment. White infants from more racially diverse neighborhoods exhibited greater frontal theta oscillation (an index of top-down attention) and more mu rhythm desynchronization (an index of motor system activation and potentially neural mirroring) to racial outgroup individuals than White infants from less racially diverse neighborhoods. Neighborhood racial demographics did not relate to White infants' frontal alpha asymmetry (a measure of approach-withdrawal motivation) toward racial outgroup individuals. Racial minority infants showed no effects of neighborhood racial demographics in their neural responses to racial outgroup individuals. These results indicate that neural mechanisms that may underlie social bias and prejudices are related to neighborhood racial demographics in the first year of life.
Improving Polyphenolic Compounds: Antioxidant Activity in Chickpea Sprouts through Elicitation with Hydrogen Peroxide

Elicitation appears to be a promising alternative to enhance the bioactive compound content and biological activities of legume sprouts. Multi-response optimization by response surface methodology (RSM) with desirability function (DF) was used to optimize the elicitor concentration (hydrogen peroxide (H2O2)) and germination time in order to maximize total phenolic content (TPC), total flavonoids content (TFC), and antioxidant activity (AOX) of chickpea sprouts. Chemical, antinutritional, and nutraceutical properties of optimized chickpea sprouts (OCS) were also determined. The predicted regression models developed were efficiently fitted to the experimental data. The results of the desirability function revealed that optimum attributes in chickpea sprouts can be achieved by the application of 30 mM H2O2 and 72 h of germination time, with global desirability value D = 0.893. These OCS had higher (p < 0.05) TPC (7.4%), total iso-flavonoids (16.5%), AOX (14.8%), and lower phytic acid (16.1%) and saponins (21.8%) compared to H2O2 non-treated chickpea sprouts. Optimized germination conditions slightly modified the flavonoid profile in chickpea; eight iso-flavonoids were identified in OCS, including formononetin and biochanin A, which were identified as the major compounds. Results from this study support elicitation with H2O2 as an effective approach to improve phytochemical content and antioxidant activity in chickpea sprouts.
Survival features, prognostic factors, and determinants of diagnosis and treatment among Iranian patients with pancreatic cancer, a prospective study

Objectives Investigating the survival features, and determinants of treatment and stage at presentation in Iran Methods 461 patients with pancreatic ductal adenocarcinoma (PC) were prospectively enrolled from Shariati hospital, Tehran, Iran, between 2011–2018. All patients underwent endoscopic ultrasonography, computed tomography scanning, and physical examination. Validated questionnaire was completed for the participants and all were actively followed on monthly basis. Results Median survival time was 6.5 months, and 1-, and 5-year survival rates were 26.2%, and 1.5%. Patients who were older (p<0.001), illiterate (p = 0.004), unmarried (p = 0.003), rural inhabitant (p = 0.013), opium user (p = 0.039), and had lower body mass index (BMI) (p = 0.002) had lower overall survival. Tumors located in the head of pancreas were more commonly diagnosed at lower stages (p<0.001). Only 10.4% of patients underwent surgery who were more commonly educated (p<0.001), married (p = 0.005), had a tumor located in the head of pancreas (p = 0.016), and were diagnosed at lower stages (p<0.001). After adjustment for potential confounders and risk factors, rural inhabitance (HR: 1.33 (95% CI: 1.01–1.74)), having more symptoms (HR for each increasing symptom: 1.06 (1.02–1.11)), using opium (HR: 1.51 (1.04–2.20)), having a tumor located in the body of pancreas (HR: 1.33 (1.02–1.75)), and having an advanced tumor stage (HR: 2.07 (1.34–3.19)) remained significantly associated with increased risk of mortality. After the adjusting for potential confounders, we did not find significant relationships between smoking, alcohol intake, and BMI with the risk of death among patients with pancreatic cancer. Conclusions Iranian patients with PC have very poor long-term survival. Besides tumor’s stage and location, socioeconomic disparities could affect the probabilities of receiving treatment and/or survival in these patients. Opium use is an independent risk factor for mortality among PC patients in Iran.
Induction of Lactation After Adoption in a Muslim Mother With History of Breast Cancer: A Case Study

Introduction With the prevalence of infertility increasing worldwide, many are seeking adoption to fulfill the need to start or expand their family. However, one of the challenges mothers face is the lack of the early maternal bond with the adopted infant, which typically starts during pregnancy, and then continues after birth, while providing care and nourishment to the infant. Breastfeeding is proven to strengthen the maternal–infant bond and provides numerous benefits to the dyad. Reports of induced lactation in non-biological mothers are uncommon, they are even more uncommon to find in women with a history of breast cancer. Main issue The induction of lactation in a Muslim adoptive mother who had a history of breast cancer. Management Pharmacologic methods, which included galactagogues Domperidone and fenugreek, in addition to non-pharmacologic methods that included breast stimulation by using a breast pump. The participant was able to provide her own milk for her adopted infant. Conclusion When provided with proper support, an adopting mother with a history of breast radiation was able to breastfeed. The participant’s need to provide her own expressed milk was met; although, she was counseled on the possibility that her milk production will most likely not be sufficient to entirely meet the infant’s needs. Determination and support definitely have a role in cases where the influence of past treatment on human milk production is not known.
The Burden of Spinal Muscular Atrophy on Informal Caregivers

Spinal muscular atrophy (SMA) is one of the most common severe hereditary diseases of infancy and early childhood. The progression of this illness causes a high degree of disability; hence, a significant burden is experienced by individuals with this disease and their families. We analyzed the time taken to care for patients suffering from SMA in European countries and the burden on their informal caregivers. We designed a cross-sectional study recording data from France, Germany, Spain and the United Kingdom. The primary caregivers completed a self-administered questionnaire that included questions about the time of care, The Zarit Burden Interview, type of SMA and socio-demographic characteristics. Multivariate analyses were used to study the associations between the type of SMA, time of care and burden supported by informal caregivers. The caregivers provided 10.0 h (SD = 6.7) per day of care (the principal caregivers provided 6.9 h, SD = 4.6). The informal caregivers of patients with type I SMA had a 36.3 point higher likelihood (p < 0.05) of providing more than 10 h of care per day in comparison with caregivers of patients with type III SMA. The severity of the disease was associated with more time of care and a higher burden on the caregivers.
The Bulk Modulus-Volume Relationship for Oxides

The relationship KV_0 = constant is shown to hold for oxides as well as for alkali halides. The product of bulk modulus and volume depends on the crystal structure, valance product, and a repulsive parameter. The exponential repulsive parameter ρ is calculated for oxides in the halite, wurtzite, corundum, spinel, perovskite, and rutile structures for which elastic constant data are available. This parameter satisfies the relationship ρ = 0.05 (1 + R + 3ΔR where R is the cube root of the molecular volume and ΔR is the difference between R and the radius of the small cation. The reduced Madelung constant α = A/mz_1z_2 (where A is the conventional Madelung constant, z_1z_2 is the valence product, and m is the number of ions in the chemical formula) satisfies the relation α = 0.20 + 0. 45ΔR. The calculated values for the bulk modulus and the repulsive parameter can be used to estimate densities at pressures of a megabar with an accuracy of about 1%.
Structural, Optical, Electrical, and Magnetic Properties of PVA:Gd3+ and PVA:Ho3+ Polymer Films

Polymer films of PVA:Gd3+ and PVA:Ho3+ have been synthesized by a solution casting method in order to study their structural, optical, electrical, and magnetic properties. The semicrystalline nature of the polymer films has been confirmed from XRD analysis. The FTIR analysis confirms the complex formation of the polymer with the metal ions. Dielectric studies of these films have also been carried out at various set temperatures in the frequency from 100 Hz to 1 MHz for carrying out impedance spectroscopy analysis to evaluate the electrical conductivity which arises due to a single conduction mechanism and thus to have a single semicircle pattern from these polymer films. The DC electrical conductivity increases with an increase in the temperature and it could be due to high mobility of free charges (polarons and free ions) at higher temperatures. The conductivity trend follows the Arrhenius equation for PVA:Gd3+ and for PVA:Ho3+ polymer films. PVA:Gd3+ polymer films show ferromagnetic nature, and PVA:Ho3+ polymer films have revealed paramagnetic nature based on the trends noticed in the magnetic characteristic profiles.
Bridging particle deformability and collective response in soft solids

Soft, amorphous solids such as tissues, foams, and emulsions are composed of deformable particles. However, the effect of single-particle deformability on the collective behavior of soft solids is still poorly understood. We perform numerical simulations of two-dimensional jammed packings of explicitly deformable particles to study the mechanical response of model soft solids. We find that jammed packings of deformable particles with excess shape degrees of freedom possess low-frequency quartic vibrational modes that stabilize the packings even though they possess fewer interparticle contacts than the nominal isostatic value. Adding intra-particle constraints can rigidify the particles, but these particles undergo a buckling transition and gain an effective shape degree of freedom when their preferred perimeter is above a threshold value. We find that the mechanical response of jammed packings of deformable particles with shape degrees of freedom differs significantly from that of jammed packings of rigid particles even when they are compressed well above jamming onset, which emphasizes the importance of particle deformability in modelling soft solids.
NUTRITIONAL AND MEDICAL IMPORTANCE OF CITRULLUS COLOCYNTHIS-A REVIEW

For ages, plants are used for medication purpose to treat various disorders to improve health and wellness. Now a day, consumption of synthetic drugs has increased which further cause side effects and adversely affect health of the population. However, health consciousness and increase in knowledge about side effects of synthetic drugs tends to further enhancing the interest towards traditional medicines. Medicinal plants help to cure diseased condition for further improved living, so that importance of ‘ethno-medicine’ study was realized by population and more use of herb based medicines was come in demand for further use. India is a country with diversification in culture as well as in botanical geography. The use of botanical knowledge for medication of different ailments and diseases is the cohesive part of Indian rural population. Citrullus colocynthis is herbaceous plant packed with abundance of nutrients which plays key role in improvement of wellbeing. This is an underutilized and less known fruit crop of arid region. Almost all parts of such fruit crop used for health benefits. Seeds are rich source of oil and protein with superior fatty acid and amino acid profile. Other than nutrients, there are number of bioactive compounds such as cucurbitacin, flavonoids and polyphenols are present in Citrullus colocynthis which are further responsible for medicinal properties. Although, consumption of such plant is common in rural population but further investigations are required to improve the utilization of this super food.
Ordinary least squared linear regression model for estimation of zinc in wild edible mushroom (Suillus luteus (L.) Roussel)

Ivanova, M. T. , Radoukova, Tz. I. , Dospatliev, L. K. & Lacheva, M. N. (2020). Ordinary least squared linear regression model for estimation of zinc in wild edible mushroom (Suillus luteus (L.) Roussel). Bulg. J. Agric. Sci., 26 (4), 863–869 Suillus luteus (L.) Roussel is a basidial fungus, and the type species of the genus Suillus. A common fungus native to Eurasia, from the British Isles to Korea, it has been introduced widely elsewhere, including North and South America, southern Africa, Australia and New Zealand.The aims of this work were to determine trace elements (Pb, Cd, Co, Cu, Mn, Zn and Fe) contents in the wild edible mushroom S. luteus growing in the Batak Mountain, Bulgaria and to identify the relationship between Zn and the other elements using ordinary least squares multiple linear regression model. Quantitative determination of the concentration of the studied trace elements was carried out in mineralized samples by Perkin Elmer A Analyst 800 atomic absorption spectrometer with deuterium background corrector. All statistical computing, analysis and all charts were performed with the statistical software R program. The ordinary least squares linear regression model was obtained for Zn. Based on the obtained model, the following interpretations for Zn contents in the wild edible mushroom S. luteus growing in the Batak Mountain, Bulgaria could be made: if Fe and Cd increase by 1%, the effect of this increase would result in an increase in Zn by 15.245% on the average; if Mn, Cu, Co and Pb decreases by 1%, the effect of this decrease would result in an decrease in Zn by 3.582% on the average.
THE EFFECT OF SOME PLANT GROWTH RETARDANTS AND WATER STRESS ON SOME TRAITS OF SORGHUM (SORGHUM BICOLOR L. MOENCH) STEM

A field experiment was conducted in the research farm of Field Crops Department College of Agricultural Engineering Sciences University of Baghdad (Jadiriya) in the spring season of 2019, in order to try shortening the height of the sorghum (bohooth70). As well as, increasing the stem diameter to reduce lodging, using some growth retardants and water stress according to Randomized Complete Block Design (RCBD) using the split-plot design arrangement with three replicates. The water stress treatments were distributed over the main plots at two levels, full irrigation (irrigation at depletion 50-60% of the available water), and irrigation with half water quantity of the full irrigation treatment. As for the sub plots, it includes the plant growth retardants, including comparison and grafting with calcium carbide (CaC2) 2 g.plant , spraying with Cycocel (CCC) 750 mg.L, spraying with Salicylic (SA) 250 mg.L, in addition to the treatments of combining treatments with the same concentrations, CCC + SA, CCC + CaC, SA + CaC2, and CCC + SA + CaC2.The results showed a significant decrease in the characteristics of vegetative growth in irrigation with the treatment 50%, such as plant height, stem height at the middle of the lower internodes number, number of internodes, stem diameter, stem dry weight and lodging percentage. The growth retardants was significantly increased the stem diameter, while it decreased the lodging percentage, stem dry weight and number of internodes. The treatment of combining the growth retardants treatments (CaC2+CCC+SA) was significantly superior in reducing plant height and stem dry weight significantly. The interaction between irrigation treatments with growth retardants achieved significant differences in plant height, stem dry weight and lodging percentage.
2020 Constitutional Reform and Center-Region Relations in Russia

This article examines 2020 constitutional reform in Russia. The amendments recently were approved on July, 1st by nation-vide vote. The purpose of the article is to analyze center-region trends in Russia and how they are reflected in the proposed constitutional amendments. The prospective changes in regional representation in the federal decision-making process shall also be discussed. The article shows how chaotic decentralization during the 90-s was replaced by a trend of centralization. The 2020 constitutional reform reflects a further strengthening of this centralization trend. The problems faced by the Russian regions are left unresolved. It is becoming an overcentralized country. The amended Russian Constitution envisages a reformed role for the Russian State Council. It is supposed to be defined in the Constitution as a consultative body by the President and is expected to be formed of regional leaders. At the same time, the Federal Council of the Federal Assembly (the upper chamber of the Russian parliament), which represents the different constituencies, is also set to be reformed. However, after the reform some of its powers shall be restricted. The changes to regional representation in the federal decision-making process has a controversial and inconsistent character and inevitably supports the general trend towards centralization.