Miracle-dz/UniFAR-FTUs huggingface dataset:
One size does not fit all: Variation in anatomical traits associated with emersion behavior in mudskippers (Gobiidae: Oxudercinae)

Life histories involving transitions between differing habitats (i.e., aquatic to terrestrial or marine to freshwater) require numerous anatomical, physiological, and behavioral changes. Often, the traits associated with these changes are thought to come in suites, but all traits thought to be associated with particular life histories may not be required. While some traits are found in all species with a particular habitat transition, a grab bag approach may apply to other traits in that any trait may be sufficient for successful habitat transitions. We examine patterns of morphological traits associated with prolonged emersion in mudskipper, an amphibious fishes clade, where prolonged emersion appears twice. We test the evolutionary history of multiple characteristics associated with cutaneous respiration. We find most traits thought to be key for prolonged emersion show no phylogenetic signal and no tight correlation with prolonged emersion. Such traits appear in species with prolonged emersion but also non-emerging species. Only capillary density, which, when increased, allows for increased oxygen absorption, shows strong phylogenetic signal and correlation with prolonged emersion. Further experimental, functional genomics, and observational studies are needed to fully understand the mechanisms associated with each of these traits. With respect to traits associated with other particular behaviors, a comparative framework can be helpful in identifying evolutionary correlates.
QTL analysis identified two major all-internodes solidness loci from a completely solid-stemmed spring wheat line

The culms of solid-stemmed wheat cultivars are filled with “pith” – a parenchymatous tissue largely composed of soft, spongy, and compact parenchyma cells. Breeding solid-stemmed cultivars is the most effective way to decrease the detrimental impact of wheat stem sawfly (WSS), Cephus cinctus Norton (Hymenoptera: Cephidae) on wheat production. Although a major solid stem gene has been previously identified from durum wheat, it produces an intermediate level of stem solidness in common wheat which is insufficient to provide the required level of WSS resistance. The maximum resistance is achieved when stems are totally filled with pith. Thus, to identify a secondary source of solidness in common wheat, we developed three mapping populations from wheat cvs. Sadash, ‘AAC Innova’ and ‘AAC Cameron’, each crossed separately with P2711, a completely solid-stemmed hexaploid wheat breeding line. All populations were genotyped using either wheat 15K or 90K Infinium iSelect SNP Assay and high-density linkage maps were generated from individual populations along with consensus maps for chromosomes 3B and 3D from all populations. ‘Sadash/P2711’ and ‘AAC Innova/P2711’ populations were subjected to extensive phenotyping in ≥3 environments followed by quantitative trait loci (QTL) analyses using population-specific and consensus linkage maps. We identified two major solid stem QTLs in the distal regions of chromosome arms 3BL and 3DL in both populations in addition to several population-specific or common minor QTLs. Internode-specific QTL analyses detected both major QTLs of chromosomes 3B and 3D across internodes, from top to bottom of the stalk, but minor QTLs were largely detected in upper or middle internodes. Our results suggest that both major QTLs are sufficient to develop highly solid-stemmed cvs; however, the minor loci, which additively enhance the pith expression, can be coupled with major genes to achieve a complete solid stem phenotype in common wheat. Comparative and haplotype analyses showed that the 3B locus is homoeologous to 3D, the former being mapped to a 1.1 Mb genomic region. Major QTLs identified in this study can be incorporated in modern wheat cultivars to achieve maximum WSS resistance from high pith expression.
Environmental sustainability through green HRM: Measuring the perception of university managers

Environmental sustainability has gained great momentum worldwide especially in the United Nations (UN), governments, and corporations, and by those who promote global awareness of environmental challenges and are engaged in environmental management. Even as these stakeholders struggle hard, academia has actively engaged in an ongoing debate to make “green human resource management” an independent field of research and teaching. From the large body of academic literature, it has been observed that the field is yet in its embryonic stage in many developing countries such as Pakistan and there is insufficient knowledge on how universities face and manage environmental challenges. Hence, this study addressed this gap in the literature and measured the perception of public and private sector university managers regarding environmental sustainability by using a multi-respondent multi-wave design and collected data from academic heads/supervisors and university faculty in three-time intervals. The data found support for all the hypothetical relationships. The study revealed that the green human resource management (GHRM) practices of public and private universities have a positive impact on environmental sustainability through the mediation of innovative work behavior of employees.
Effects of caffeinated beverage ingestion on salivary antimicrobial proteins responses to acute exercise in the heat

Caffeine is commonly used by athletes as an energy supplement, but studies on its effects on salivary antimicrobial proteins (sAMPs) in humans during exercise are rare with ambiguous findings. It is also still controversial whether hot environments affect sAMPs. Using a double-blind, randomized crossover design, we examined 12 endurance-trained male collegiate athletes who completed the following two experiments: a caffeine experiment (CAF) and a placebo experiment (PLA). The participants acutely consumed caffeine-containing (6 mg/kg body weight) sports drink (3 ml/kg body weight) or an equivalent amount of placebo sports drink and subsequently performed cycling exercise for 40 min in the heat (33 ± 0.24°C, 64 ± 2.50% relative humidity) at 50% of maximum output power, maintaining a pedal frequency of 60 rpm. Saliva was collected at 60 min pre-exercise (T–60), the start of exercise (T0), 20 min of exercise (T20), and the end of the exercise (T40), and salivary α-amylase (sAA) and lactoferrin (sLac) were tested. The rating of perceived exertion (RPE) was measured at T0–T40, while core body temperature (Tre) and heart rate (HR) were monitored continuously. Tre, HR, and RPE increased with time during the exercise (p < 0.01), with no difference in Tre and HR between the CAF and PLA (p > 0.05), but RPE was higher in the PLA than in the CAF (p < 0.05). sLac concentrations were significantly higher at T20 and T40 than at T–60 (p < 0.01) and higher at T40 than at T0 and T20 (p < 0.01), with no difference between the CAF and PLA (p > 0.05). Compared with T–60, sAA activity was significantly increased at T0, T20, and T40 (p < 0.01). sAA activity was significantly higher at T40 than at T0 and T20 (p < 0.01), at T20 than at T0 (p < 0.05), and in the CAF than in the PLA (p < 0.01). Heat stress caused by acute exercise in hot environments did not impair the sAMPs parameters of the participants. Instead, the participants showed transient increase in sAA activity and unchanged sLac concentrations. Caffeine may increase salivary markers related to immune response during exercise.
Influence of multiple global change drivers on plant invasion: Additive effects are uncommon

Invasive plants threaten biodiversity and cause huge economic losses. It is thought that global change factors (GCFs) associated with climate change (including shifts in temperature, precipitation, nitrogen, and atmospheric CO2) will amplify their impacts. However, only few studies assessed mixed factors on plant invasion. We collated the literature on plant responses to GCFs to explore independent, combined, and interactive effects on performance and competitiveness of native and invasive plants. From 176 plant species, our results showed that: (1) when native and invasive plants are affected by both independent and multiple GCFs, there is an overall positive effect on plant performance, but a negative effect on plant competitiveness; (2) under increased precipitation or in combination with temperature, most invasive plants gain advantages over natives; and (3) interactions between GCFs on plant performance and competitiveness were mostly synergistic or antagonistic. Our results indicate that native and invasive plants may be affected by independent or combined GCFs, and invasive plants likely gain advantages over native plants. The interactive effects of factors on plants were non-additive, but the advantages of invasive plants may not increase indefinitely. Our findings show that inferring the impacts of climate change on plant invasion from factors individually could be misleading. More mixed factor studies are needed to predict plant invasions under global change.
Exel's crossed product and crossed products by completely positive maps

We introduce crossed products of a $C^*$-algebra $A$ by a completely positive map $\varrho:A\to A$ relative to an ideal in $A$. They generalize various crossed products by endomorphisms when $\varrho$ is multiplicative. When $A$ is commutative they include $C^*$-algebras associated to Markov operators by Ionescu, Muhly, Vega, and to topological relations by Brenken, but in general they are not modeled by topological quivers popularized by Muhly and Tomforde. We show that Exel's crossed product $A\rtimes_{\alpha,L} \mathbb{N}$, generalized to the case where $A$ is not necessarily unital, is the crossed product of $A$ by the transfer operator $L$ relative to the ideal generated by $\alpha(A)$. We give natural conditions under which $\alpha(A)$ is uniquely determined by $L$, and hence $A\rtimes_{\alpha,L} \mathbb{N}$ depends only on $L$. Moreover, the $C^*$-algebra $\mathcal{O}(A,\alpha,L)$ associated to $(A,\alpha,L)$ by Exel and Royer always coincides with our unrelative crossed product by $L$. As another non-trivial application of our construction we extend a result of Brownlowe, Raeburn and Vittadello, by showing that the $C^*$-algebra of an arbitrary infinite graph $E$ can be realized as a crossed product of the diagonal algebra $\mathcal{D}_E$ by a `Perron-Frobenious' operator $L$. The important difference is that in general there is no endomorphism $\alpha$ of $\mathcal{D}_E$ making $(\mathcal{D}_E,\alpha,L)$ an Exel system.
The geriatric nutritional risk index is an effective tool to detect GLIM-defined malnutrition in rectal cancer patients

Background This study aimed to investigate the value of the Geriatric Nutritional Risk Index (GNRI), prognostic nutritional index (PNI), and advanced lung cancer inflammation index (ALI) scores in detecting malnutrition in patients with rectal cancer; the Global Leadership Initiative on Malnutrition (GLIM) was used as the reference criterion. Materials and methods This study included patients with rectal cancer who underwent proctectomy. GNRI, PNI, and ALI were calculated to detect the GLIM-defined malnutrition using the Receiver operating characteristic (ROC) curves. Univariate and multivariate logistic regression analyses were used to evaluate the association between the nutritional tools and postoperative complications. Kaplan-Meier survival curves, log-rank tests, and univariate and multivariate Cox regression analyses were used to clarify the relationship between nutritional tools and overall survival (OS). Results This study enrolled 636 patients with rectal cancer. The GNRI demonstrated the highest sensitivity (77.8%), pretty specificity (69.0%), and the largest AUC (0.734). The GNRI showed good property in predicting major postoperative complications. All three nutritional tools were independent predictors of OS. Conclusion The GNRI can be used as a promising alternative to the GLIM and is optimal in perioperative management of patients with rectal cancer.
Cotton leaf curl Multan virus differentially regulates innate antiviral immunity of whitefly (Bemisia tabaci) vector to promote cryptic species-dependent virus acquisition

Begomoviruses represent the largest group of economically important, highly pathogenic, DNA plant viruses that contribute a substantial amount of global crop disease burden. The exclusive transmission of begomoviruses by whiteflies (Bemisia tabaci) requires them to interact and efficiently manipulate host responses at physiological, biological and molecular scales. However, the molecular mechanisms underlying complex begomovirus-whitefly interactions that consequently substantiate efficient virus transmission largely remain unknown. Previously, we found that whitefly Asia II 7 cryptic species can efficiently transmit cotton leaf curl Multan virus (CLCuMuV) while MEAM1 cryptic species is a poor carrier and incompetent vector of CLCuMuV. To investigate the potential mechanism/s that facilitate the higher acquisition of CLCuMuV by its whitefly vector (Asia II 7) and to identify novel whitefly proteins that putatively interact with CLCuMuV-AV1 (coat protein), we employed yeast two-hybrid system, bioinformatics, bimolecular fluorescence complementation, RNA interference, RT-qPCR and bioassays. We identified a total of 21 Asia II 7 proteins putatively interacting with CLCuMuV-AV1. Further analyses by molecular docking, Y2H and BiFC experiments validated the interaction between a whitefly innate immunity-related protein (BTB/POZ) and viral AV1 (coat protein). Gene transcription analysis showed that the viral infection significantly suppressed the transcription of BTB/POZ and enhanced the accumulation of CLCuMuV in Asia II 7, but not in MEAM1 cryptic species. In contrast to MEAM1, the targeted knock-down of BTB/POZ substantially reduced the ability of Asia II 7 to acquire and accumulate CLCuMuV. Additionally, antiviral immune signaling pathways (Toll, Imd, Jnk and Jak/STAT) were significantly suppressed following viral infection of Asia II 7 whiteflies. Taken together, the begomovirus CLCuMuV potentiates efficient virus accumulation in its vector B. tabaci Asia II 7 by targeting and suppressing the transcription of an innate immunity-related BTB/POZ gene and other antiviral immune responses in a cryptic species-specific manner.
A systematic review of the effect of university positive psychology courses on student psychological wellbeing

Educational courses that teach positive psychology interventions as part of university degree programs are becoming increasingly popular, and could potentially form part of university-wide strategies to respond to the student mental health crisis. To determine whether such courses are effective in promoting student wellbeing, we conducted a systematic review of studies across the globe investigating the effects of positive psychology courses taught within university degree programs on quantitative measures of psychological wellbeing. We searched Embase, PsychInfo, PubMed, and Web of Science electronic databases from 1998 to 2021, identifying 27 relevant studies. Most studies (85%) reported positive effects on measures of psychological wellbeing, including increased life satisfaction and happiness. However, risk of bias, assessed using the ROBINS-I tool, was moderate or serious for all studies. We tentatively suggest that university positive psychology courses could be a promising avenue for promoting student wellbeing. However, further research implementing rigorous research practices is necessary to validate reported benefits, and confirm whether such courses should form part of an evidence-based response to student wellbeing. Systematic review registration [https://www.crd. york.ac. uk/prospero/display_record. php? RecordID=224202], identifier [CRD42020224202].
Under the sword of Damocles: Exploring the well-being of university academics during a crisis

Prompted by the wide-spread impact of the global pandemic on the higher education sector in Australia, this study explores the wellbeing and mental health of university academics who were caught in this altering landscape. This mixed-methods study has three objectives. Firstly, the study involved the design and development of an instrument to measure the wellbeing of university teachers. Secondly, the new instrument was administered to a randomly drawn sample of university academics, in order to validate its use. Thirdly, the study sought to identify possible strategies utilized by participants during times of high pressure, conflict and stress. As an initial validation study, the project involved scale design, generating a tool which measures the wellbeing of university academics, especially during times of crisis. The measurement tool was constructed in four parts drawing on the established formula of academic workload: Teaching, Research, Service/Engagement, with Part 4 seeking out demographic variables for analysis. Findings suggested that most academics were concerned about the maintenance of their research output and teaching workloads. Maintaining responsibilities as care-givers and parents of school-going children proved challenging. Many conceded that maintaining equilibrium was complex. It is anticipated that the scale will be an effective means of quantifying academic wellbeing especially during a crisis, thereby offering a valid instrument to university leaders, when considering staff security and comfort, in the contemporary context.
Efficacy and safety of belantamab-mafodotin in triple-refractory multiple myeloma patients: A multicentric real-life experience

Belantamab-mafodotin is an innovative and selective treatment for multi-refractory/relapsed multiple myeloma (MM) patients; however, available real-life experiences on efficacy and safety are limited. In this real-world multicentric retrospective study, we enrolled 28 MM patients treated in four Hematology units of Campania region, Italy, who received a median of six treatment lines prior to belantamab-mafodotin. The overall response rate (ORR) was 40% (complete remission, CR, 11%; very good partial remission, VGPR, 11%; and partial remission, PR, 18%), with a median progression-free survival (PFS) and overall survival (OS) of 3 and 8 months, respectively. One of the most frequent drug-related adverse events was keratopathy observed in nine (32%) patients, leading to therapy discontinuation in only three (11%) of them. Moreover, 22 out of 28 total patients who were treated with at least two administrations achieved an ORR of 50% (CR, 14%; VGPR, 14%; and PR, 22%) with a median PFS and OS of 5 and 11 months, respectively. In conclusion, our multicentric study confirmed efficacy and safety of belantamab-mafodotin in triple-refractory MM patients even in the real-life setting.
The prevalence, comorbidities, influencing factors, and identifying factors of non-obese fatty liver disease

Objective To analyze the prevalence, associated comorbidities, influencing factors, and identifying factors of non-obese fatty liver disease and to provide a reference for its prevention and treatment. Materials and methods Firstly, to screen data obtained from the physical examinations of individuals conducted in the Second Affiliated Hospital of Xi’an Jiaotong University in 2021, subjects with complete data of abdominal ultrasonography, body mass index, age and sex were selected to analyze the prevalence of fatty liver disease and non-obese fatty liver disease. Secondly, to screen non-obese subjects who had data for triglycerides, fasting blood glucose, and so on, to analyze the complications, influencing factors, and identifying factors of non-obese fatty liver disease. Results The prevalence of fatty liver disease was 27.8% (18,416/66,221), including 33.9% (11,921/35,131) in males and 20.9% (6,495/31,090) in females, revealing that the prevalence was significantly higher in males than in females (P < 0.001). There were 40,673 non-obese subjects screened in total, and the prevalence of non-obese fatty liver disease was 13.0% (5,307/40,673). The prevalence of non-obese fatty liver disease was 13.3% (2,208/16,572) in males and 12.9% (3,099/24,101) in females; the difference was not statistically significant (P = 0.17). The serum triglycerides level was elevated in 54.2% of subjects with non-obese fatty liver disease, and this was the most common abnormal metabolic index accompanying the disease. Logistic regression analysis showed that gender, age, body mass index, blood pressure, alanine aminotransferase, aspartate aminotransferase, fasting blood glucose, triglycerides, total cholesterol, and serum uric acid were independent risk factors for non-obese fatty liver disease (P < 0.001). For triglycerides, the area under the receiver operating characteristic curve in predicting non-obese fatty liver disease was the greatest (0.806). Conclusion The prevalence of fatty liver disease and non-obese fatty liver disease determined by the physical examination of individuals was high, and the triglycerides is likely to be useful for the extensive screening of non-obese fatty liver disease.
Analyses on safety and efficacy of non-standard dose of r-tPA in intravenous thrombolysis-treated AIS patients

Background Intravenous 0.9 mg/kg recombinant tissue plasminogen activator (r-tPA) is one of the most effective treatments in acute ischemic stroke patients. Practically, the dose of r-tPA is still a topic that is constantly being discussed. Methods For this observational study, data were obtained from 537 patients who received r-tPA thrombolysis at Shanghai Sixth People's Hospital stroke center over 5 years (2014–2019). Patients were divided into two groups: a non-standard dose group (0.6 mg/kg ≤ dose < 0.9 mg/kg) and a standard dose group (0.9 mg/kg). Different outcomes were observed: efficacy: 3 months mRS 0-1 (3m-mRS0-1); safety: symptomatic intracranial hemorrhage within 24 h (24h-sICH) and 3 months mortality (3m-death). We also observed the effect of r-tPA dose coefficient on outcomes in different age groups and baseline National Institute of Health stroke scale (NIHSS) score subgroups. Results There were 265 patients who gave the standard dose treatment and 272 gave the nonstandard dose. There was no significant difference between the non-standard dose group and the standard dose group in 3m-mRS0-1, 3m-death, and 24h-sICH (p = 0.567, 0.327, and 0.415, respectively). The dose coefficient presents a significant negative correlation (p = 0.034, B = −4.290) with 3m-death in NIHSS < 16 sub-group. Door-to-needle time (DNT) is the most important independent outcome-influential factor (MIOIF) in the NIHSS ≥16 sub-group. The diabetes history and baseline NIHSS score were the MIOIF in the age ≥80-year sub-group. Conclusions The non-standard dose group (0.6 mg/kg ≤ dose < 0.9 mg/kg) shows no difference in safety and effectiveness than the standard dose group (0.9 mg/kg) in our study. The standard dose should be considered first according to current evidence and Guidelines, but the non-standard dose (0.6 mg/kg ≤ dose < 0.9 mg/kg) might be an option in the actual diagnosis and treatment process considering the patient's clinical profile and financial condition.