Miracle-dz/UniFAR-FTUs huggingface dataset:
Cardiac and Kidney Adverse Effects of HIF Prolyl-Hydroxylase Inhibitors for Anemia in Patients With CKD Not Receiving Dialysis: A Systematic Review and Meta-analysis.

RATIONALE & OBJECTIVE Hypoxia-inducible factor prolyl hydroxylase inhibitors (HIF-PHIs) are novel, orally administered agents for anemia management in chronic kidney disease (CKD). We evaluated the cardiac and kidney-related adverse effects of HIF-PHIs among patients with CKD. STUDY DESIGN Systematic review and meta-analysis of randomized controlled trials (RCTs). SETTING & STUDY POPULATIONS Patients with anemia and CKD not receiving maintenance dialysis. SELECTION CRITERIA FOR STUDIES RCTs comparing HIF-PHIs to placebo or an erythropoiesis-stimulating agent (ESA) with primary outcomes of cardiac and kidney-related adverse events. DATA EXTRACTION Two independent reviewers evaluated RCTs for eligibility and extracted relevant data. ANALYTICAL APPROACH Dichotomous variables were pooled using the Mantel-Haenszel method and presented as risk ratios (RRs) with 95% confidence intervals (CI). Subgroup analyses evaluated different intervention times and HIF-PHIs, as well as phase 2 vs. phase 3 trials. The certainty of findings was rated according to GRADE criteria. RESULTS Twenty-three studies with 15,144 participants were included. No significant difference in the risk of cardiac disorders was observed between the HIF-PHIs group and the placebo (RR=1.02; 95% CI, [0.89 to 1.16]; moderate certainty) or ESA groups (RR=1.06; 95% CI, [0.98 to 1.14]; low certainty). No significant difference in the risk of kidney-related adverse events was observed between the HIF-PHIs group and the placebo (RR=1.09; 95% CI, [0.98 to 1.20]; moderate certainty) or ESA groups (RR=1.00; 95% CI, [0.94 to 1.06]; low certainty). The occurrence of hypertension and hyperkalemia was higher in the HIF-PHIs group than in the placebo group (RR=1.35; 95% CI, [1.14 to 1.60]; high certainty and RR=1.25; 95% CI, [1.03 to 1.51]; high certainty, respectively). The occurrence of hypertension was lower in the HIF-PHIs group than in the ESA group (RR=0.89; 95% CI, [0.81 to 0.98]; moderate certainty). LIMITATIONS The reporting criteria of cardiac and kidney-related events and dosage of HIF-PHIs were inconsistent across trials. CONCLUSIONS The occurrence of cardiac or kidney-related adverse events in the HIF-PHI groups were not different compared with placebo or ESA groups. REGISTRATION Registered at PROSPERO with record number CRD42021228243.
Hydrodynamical models of cometary H II regions

We have modelled the evolution of cometary H ii regions produced by zero-age main-sequence stars of O and B spectral types, which are driving strong winds and are born off-centre from spherically symmetric cores with power-law (α = 2) density slopes. A model parameter grid was produced that spans stellar mass, age and core density. Exploring this parameter space, we investigated limb-brightening, a feature commonly seen in cometary H ii regions. We found that stars with mass M⋆ ≥ 12 M⊙ produce this feature. Our models have a cavity bounded by a contact discontinuity separating hot shocked wind and ionized ambient gas that is similar in size to the surrounding H ii region. Because of early pressure confinement, we did not see shocks outside of the contact discontinuity for stars with M⋆ ≤ 40 M⊙, but the cavities were found to continue to grow. The cavity size in each model plateaus as the H ii region stagnates. The spectral energy distributions of our models are similar to those from identical stars evolving in uniform density fields. The turn-over frequency is slightly lower in our power-law models as a result of a higher proportion of low-density gas covered by the H ii regions.
Fabrication of Low Loss Lithium Niobate Rib Waveguides Through Photoresist Reflow

We present lithography and argon plasma etching of lithium niobate on insulator (LNOI) rib waveguides using reflowed photoresist etch masks and 405 nm photolithography. Melting the photoresist at temperatures greatly exceeding its glass transition temperature while minimizing feature distortion through photoresist adhesion control reduces sidewall surface roughness and allows the photoresist to be used both as the pattern mask and the hard etch mask. Waveguide sidewall surfaces exhibiting sub-nm root mean square roughness are fabricated. Dependence of sidewall roughness and angle on feature width, and propagation loss on thermal annealing of the fabricated devices is characterized. Measured quality factors on fabricated microresonators exceed one million. LNOI rib waveguides and resonators with low propagation loss increase nonlinear optical conversion efficiencies and are useful for efficient electro-optic modulation. Photolithography compatible fabrication of low loss LNOI photonic integrated circuits facilitates scalable commercialization.
Dynamical histories of the IC 348 and NGC 1333 star-forming regions in Perseus

We present analyses of the spatial distributions of stars in the young (1–3 Myr) star-forming regions IC 348 and NGC 1333 in the Perseus giant molecular cloud. We quantify the spatial structure using the Q-parameter and find that both IC 348 and NGC 1333 are smooth and centrally concentrated with Q-parameters of 0.98 and 0.89, respectively. Neither region exhibits mass segregation (MSR = 1.1+0.2 −0.3 for IC 348 and MSR = 1.2+0.4 −0.3 for NGC 1333, where MSR ∼ 1 corresponds to no mass segregation) nor do the most massive stars reside in areas of enhanced stellar surface density compared to the average surface density, according to the LDR method. We then constrain the dynamical histories and hence initial conditions of both regions by comparing the observed values to N-body simulations at appropriate ages. Stars in both regions likely formed with subvirial velocities that contributed to merging of substructure and the formation of smooth clusters. The initial stellar densities were no higher than ρ ∼ 100–500 M pc−3 for IC 348 and ρ ∼ 500–2000 M pc−3 for NGC 1333. These initial densities, in particular that of NGC 1333, are high enough to facilitate dynamical interactions that would likely affect ∼10 per cent of protoplanetary discs and binary stars. Key
Variability Timescale and Spectral Index of Sgr A* in the Near Infrared: Approximate Bayesian Computation Analysis of the Variability of the Closest Supermassive Black Hole

Sagittarius A* (Sgr A*) is the variable radio, near-infrared (NIR), and X-ray source associated with accretion onto the Galactic center black hole. We present an analysis of the most comprehensive NIR variability data set of Sgr A* to date: eight 24 hr epochs of continuous monitoring of Sgr A* at 4.5 μm with the IRAC instrument on the Spitzer Space Telescope, 93 epochs of 2.18 μm data from Naos Conica at the Very Large Telescope, and 30 epochs of 2.12 μm data from the NIRC2 camera at the Keck Observatory, in total 94,929 measurements. A new approximate Bayesian computation method for fitting the first-order structure function extracts information beyond current fast Fourier transformation (FFT) methods of power spectral density (PSD) estimation. With a combined fit of the data of all three observatories, the characteristic coherence timescale of Sgr A* is minutes (90% credible interval). The PSD has no detectable features on timescales down to 8.5 minutes (95% credible level), which is the ISCO orbital frequency for a dimensionless spin parameter a = 0.92. One light curve measured simultaneously at 2.12 and 4.5 μm during a low flux-density phase gave a spectral index αs = 1.6 ± 0.1 ( ). This value implies that the Sgr A* NIR color becomes bluer during higher flux-density phases. The probability densities of flux densities of the combined data sets are best fit by log-normal distributions. Based on these distributions, the Sgr A* spectral energy distribution is consistent with synchrotron radiation from a non-thermal electron population from below 20 GHz through the NIR.
Mirror World at the Large Hadron Collider

A mirror world can modify in a striking way the LHC signals of the Higgs sector. An exact or approximate Z2 symmetry between the mirror world and our world allows large mixing between the Higgs bosons of these worlds, leading to production rates and branching ratios for these states that are markedly different from the standard model and are characteristic of a mirror world. The constraints on these Higgs boson masses from precision electroweak data differ from the standard model bound, so that the new physics that cancels the quadratic divergence induced by the top quark may appear at a larger scale, possibly beyond the reach of the LHC. However, the scale of new physics needed to cancel the quadratic divergence induced by the Higgs boson is not significantly changed. With small breakings of the Z2 parity, the lightest mirror quarks (and possibly charged mirror leptons) could be the dark matter in the universe, forming galactic halos that are stable to cooling. A possible signal from the relic radiation density of the mirror world is also discussed.
The Effect of Spiritual Leadership and Psychological Empowerment on Employee Performance

This article aimed to examine and analyze the effect of Spiritual Leadership and Psychological Empowerment on Employee Performance. Respondents were leaders or employees at YPPBU (Bahrul Ulum Islamic Boarding School Foundation) Jombang, totalling 64 respondents. Data were analyzed using Partial Least Square (PLS) with SmartPLS software version 3.0 and the relationship between variables. The results showed that Spiritual Leadership had no significant effect on Employee Performance (T Statistics: 0.925, P Values: 0.355). Psychological Empowerment has a considerable impact on Employee Performance (T statistic: 7,790, P Values: 0.000). Spiritual Leadership has a significant effect on Psychological Empowerment (T Statistics: 6,531, P Values: 0.000). Furthermore, Spiritual Leadership and Psychological Empowerment have no specific considerable impact on Employee Performance (T Statistics: 3,966, P Values: 0.000). Psychological Empowerment has a mediating role on Spiritual Leadership to Employee performance. The Spiritual Leadership and Psychological Empowerment felt by YPPBU's Leaders or Employees are directly proportional to the resulting performance. Changes in Spiritual Leadership and Psychological Empowerment will also affect Employee Performance.
Adverbial, Descriptive Reciprocals

Reciprocity was a topic very much on the minds of New Yorkers in the mid­ seventies. Fiengo & Lasnik, Dougherty, Katz, and Langendoen worried, for example, that the state of mutual respect asserted in ( 1 ) implies warm feelings between any two family members, but the actions that these feelings lead to can­ and, in this example, mustfall short of every family member kneeling at every other family member 's grave.
Suzaku Observations of Heavily Obscured (Compton-thick) Active Galactic Nuclei Selected by the Swift/BAT Hard X-Ray Survey

We present a uniform broadband X-ray (0.5–100.0 keV) spectral analysis of 12 Swift/Burst Alert Telescope selected Compton-thick ( ) active galactic nuclei (CTAGNs) observed with Suzaku. The Suzaku data of three objects are published here for the first time. We fit the Suzaku and Swift spectra with models utilizing an analytic reflection code and those utilizing the Monte-Carlo-based model from an AGN torus by Ikeda et al. The main results are as follows: (1) The estimated intrinsic luminosity of a CTAGN strongly depends on the model; applying Compton scattering to the transmitted component in an analytic model may largely overestimate the intrinsic luminosity at large column densities. (2) Unabsorbed reflection components are commonly observed, suggesting that the tori are clumpy. (3) Most of CTAGNs show small scattering fractions (<0.5%), implying a buried AGN nature. (4) Comparison with the results obtained for Compton-thin AGNs suggests that the properties of these CTAGNs can be understood as a smooth extension from Compton-thin AGNs with heavier obscuration; we find no evidence that the bulk of the population of hard-X-ray-selected CTAGNs are different from less obscured objects.
Blood vessel segmentation using deep learning architectures for aid diagnosis of diabetic retinopathy

ABSTRACT Diabetes mellitus is a metabolic disorder that causes a variety of vascular issues in the body. When the condition coexists with other general problems (high blood pressure, obesity, excessive cholesterol), the risk of ocular complications increases. Diabetes can damage the small blood vessels in the retina. This is referred to as diabetic retinopathy (DR). Therefore, the segmentation of the vascular network may assist in the automatic and early recognition and screening of DR. Since, manual vessel extraction is time-consuming, automation of this procedure is critical. In this paper, we focus on the implementation of different deep learning networks for accurate retinal vasculature semantic segmentation. We used three distinct models: SegNet, U-Net, and the convolutional neural network (CNN). These approaches were evaluated on three publicly available annotated databases: DRIVE, HRF, and CHASE-DB1. To compare the three proposed models with the previous methodologies, various metrics are calculated. The produced results were good and encouraging in terms of the quality of the visual diagnosis.
An examination of the early literacy skills of five- to six-year-old children who are deaf and hard of hearing

ABSTRACT Children’s early literacy skills (ELS) are closely related to literacy learning and reading comprehension performance. Children who cannot acquire early literacy skills face significant difficulties in doing so in the following years. Although it is widely known that children who are deaf and hard of hearing (DHH) perform less well in early literacy skills than their typically developing peers, there is not enough information about the magnitude of the performance differences and in which skills these occur in Turkish-speaking children who are DHH. In this study, the early literacy skills (language, vocabulary, phonological awareness and letter knowledge) of 30 Turkish-speaking DHH children and 30 with typical development (TD) attending kindergarten were compared. The Coloured Progressive Matrices Test, as well as the Turkish early language development and Turkish expressive and receptive language tests, in addition to the early literacy one, were used to determine the children’s skill levels. The results of the analysis showed that the DHH children performed at significantly lower levels in language, vocabulary and phonological awareness skills than their peers with TD, while there was no major difference between the two groups in letter knowledge. The outcomes also revealed that there were a higher number of significant relationships among the early literacy skills of the DHH children than those with TD. The findings of are further discussed in regard to their contribution to current research and practice relating to the early literacy skills of Turkish-speaking children who are DHH.
Growth performance and feed utilization of Hubbard Classic chickens fed on boiled and sundried mango (Mangifera indica Linn.) seed kernel

An investigation was undertaken to study the effects of feeding boiled mango seed kernel (BMSK) on the growth performance and feed utilization parameters of Hubbard broiler chicks with the objective of recommending the optimum level of mango seed kernel inclusion in broiler feed. The experiment was arranged in a completely randomized design with four treatments, each replicated three times with 13 birds each. One-hundred fifty-six-day-old chicks with uniform body weight (BW) were used and were distributed randomly to the four diets. The four treatment diets were control (T1) (100% maize + 0% BMSK), T2 (95% maize + 5% BMSK), T3 (90% maize + 10% BMSK) and T4 (85% maize + 15% BMSK). All the experimental chickens were weighted initially (initial BW) and lasted for 49 days during which growth performance traits were recorded. After 49 days, two birds from each replication were randomly selected and slaughtered to evaluate the effect of BMSK on the final body weight of the chicks. The results on average daily feed intake per bird for T1 and T2 were not significantly different, i.e., 71.4 and 70.8 g (P>0.05) but it was significantly higher than that of T3 and T4 which was 68.13 and 68.23 g. At the end of 7 weeks, the final BW of chicks fed on T1 and T2 were 2657 and 2644, not significantly different, but were significantly higher than that of T3 and T4 which were 2610 and 2603 g per bird, respectively. The Average daily BW gain (ADG) for the respective T1 and T2 was 53.4, 53.2 g and was significantly (P<0.05) higher than that of T3 and T4 which were 52.44 and 52.31 g per bird. The feed conversion ratio (g feed/g gain) for T1 and T2 was 1.36, 1.36 and was significantly higher than that of T3 and T4 which were 1.33 and 1.33 g per bird, respectively. Inclusion of mango seed kernel up to 15% in broiler nutrition has no detrimental effect, profitable and can be best alternative feed sources in broiler feed if treated well by using the best technical methods of anti-nutritional factors like boiling.
Interaction of AcMADS68 with transcription factors regulates anthocyanin biosynthesis in red-fleshed kiwifruit

Abstract In red-fleshed kiwifruit, anthocyanin pigmentation is a crucial commercial trait. The MYB-bHLH-WD40 (MBW) complex and other transcription factors regulate its accumulation. Herein, a new SEP gene, AcMADS68, was identified as a regulatory candidate for anthocyanin biosynthesis in the kiwifruit by transcriptome data and bioinformatic analyses. AcMADS68 alone could not induce the accumulation of anthocyanin both in Actinidia arguta fruit and tobacco leaves. However, in combination with AcMYBF110, AcMYB123, and AcbHLH1, AcMADS68 co-overexpression increased anthocyanin biosynthesis, whereas its silencing reduced anthocyanin accumulation. The results of the dual-luciferase reporter, firefly luciferase complementation, yeast two-hybrid and co-immunoprecipitation assays showed that AcMADS68 could interact with both AcMYBF110 and AcMYB123 but not with AcbHLH1, thereby co-regulating anthocyanin biosynthesis by promoting the activation of the target genes, including AcANS, AcF3GT1, and AcGST1. Moreover, AcMADS68 also could activate the promoter of AcbHLH1 surported by dual-luciferase reporter and yeast one-hybrid assays, thereby further amplifying the regulation signals from the MBW complex, thus resulting in enhanced anthocyanin accumulation in the kiwifruit. These findings may facilitate better elucidation of various regulatory mechanisms underlying anthocyanin accumulation and contribute to the quality enhancement of red-fleshed kiwifruit.
A Survey for Infall Motions toward Starless Cores. II. CS (2-1) and N2H+ (1-0) Mapping Observations

We present the results of an extensive mapping survey of "starless" cores in the optically thick line of CS (2-1) and the optically thin lines of N2H+ (1-0) and C18O (1-0). The purpose of this survey was to search for signatures of extended inward motions. A total of 53 targets were observed in the three lines with the FCRAO 14 m telescope. Thirty-three regions were mapped in both CS and N2H+, and thirty seven well-defined N2H+ cores have been identified. The N2H+ emission is generally compact enough to find a peak, while the CS and C18O emissions are more diffuse. For each core, we have derived the normalized velocity difference (δVCS) between the thick CS and thin N2H+ peak velocities. We define 10 "strong" and nine "probable" infall candidates, based on δVCS analysis and on the spectral shapes of CS lines. From our analysis of the blue-skewed CS spectra and the δVCS parameter, we find typical infall radii of 0.06-0.14 pc. Also, using a simple two-layer radiative transfer model to fit the profiles, we derive one-dimensional infall speeds, the values of half of which lie in the range of 0.05-0.09 km s-1. These values are similar to those found in L1544 by Tafalla et al., and this result confirms that infall speeds in starless cores are generally faster than expected from ambipolar diffusion in a strongly subcritical core. In addition, the observed infall regions are too extended to be consistent with the "inside-out" collapse model applied to a very low mass star. In the largest cores, the spatial extent of the CS spectra with infall asymmetry is larger than the extent of the N2H+ core by a factor of 2-3. All these results suggest that extended inward motions are a common feature in starless cores, and that they could represent a necessary stage in the condensation of a star-forming dense core.
Anaerobic Digestion of Chicken Manure Assisted by Carbon Nanotubes: Promotion of Volatile Fatty Acids Consumption and Methane Production

In this study, the effect of different concentrations of carbon nanotubes (Taunit-M; 0.5–6.5 g L−1) on the efficiency of anaerobic digestion of chicken manure is investigated. The highest positive effect on the specific production of methane is obtained when 5.0 g L−1 of carbon nanotubes are added to the anaerobic reactors. In addition, carbon nanotubes at these concentrations stimulate the biodegradation of volatile fatty acids, mainly acetate, butyrate, and finally propionate. The maximum production rate of methane increases by 15–16% in the presence of carbon nanotubes (5.0–6.5 g L−1). Also, addition of carbon nanotubes at certain concentrations increases total methane production. Finally, the addition of carbon nanotubes to the anaerobic reactors is found to the favor consumption of volatile fatty acids and improve the methane production kinetics and productivity during the anaerobic digestion of chicken manure.
Assessing the determinants of Myanmar government employees’ job satisfaction through Herzberg’s two-factor theory

Studies on Myanmar public employees’ job satisfaction are very limited. To understand which factors affect these employees’ job satisfaction, this study adopted Herzberg’s two-factor theory and tested its applicability in assessing self-administered survey data (N = 1,225). Results showed that Herzberg’s original sets of motivators and hygiene factors can measure government employees’ job satisfaction and that both motivators and factors are important in explaining job satisfaction. Specifically, public service motivation and religiosity contribute to job satisfaction, and family orientation’s negative effect on job satisfaction is statistically significant. Formulating flexible work schedules and dependent care programs can reduce employees’ work-family conflicts.
Effect of one-dimensional superlattice potentials on the band gap of two-dimensional materials

Using the tight-binding approach, we analyze the effect of a one-dimensional superlattice (1DSL) potential on the electronic structure of black phosphorene and transition metal dichalcogenides. We observe that the 1DSL potential results in a decrease of the energy band gap of the two-dimensional (2D) materials. An analytical model is presented to relate the decrease in the direct-band gap to the different orbital characters between the valence band top and conduction band bottom of the 2D materials. The direct-to-indirect gap transition, which occurs under a 1DSL potential with an unequal barrier width, is also discussed.