Miracle-dz/UniFAR-FTUs huggingface dataset:
Racial Disparities in Acromegaly and Cushing’s Disease: A Referral Center Study in 241 Patients

Abstract Context Acromegaly (ACM) and Cushing’s disease (CD) are caused by functioning pituitary adenomas secreting growth hormone and ACTH respectively. Objective To determine the impact of race on presentation and postoperative outcomes in adults with ACM and CD, which has not yet been evaluated. Methods This is a retrospective study of consecutive patients operated at a large-volume pituitary center. We evaluated (1) racial distribution of patients residing in the metropolitan area (Metro, N = 124) vs 2010 US census data, and(2) presentation and postoperative outcomes in Black vs White for patients from the entire catchment area (N = 241). Results For Metro area (32.4% Black population), Black patients represented 16.75% ACM (P = .006) and 29.2% CD (P = .56). Among the total 112 patients with ACM, presentations with headaches or incidentaloma were more common in Black patients (76.9% vs 31% White, P = .01). Black patients had a higher prevalence of diabetes (54% vs 16% White, P = .005), significantly lower insulin-like growth factor (IGF)-1 deviation from normal (P = .03) and borderline lower median growth hormone levels (P = .09). Mean tumor diameter and proportion of tumors with cavernous sinus invasion were similar. Three-month biochemical remission (46% Black, 55% White, P = .76) and long-term IGF-1 control by multimodality therapy (92.3% Black, 80.5% White, P = .45) were similar. Among the total 129 patients with CD, Black patients had more hypopituitarism (69% vs 45% White, P = .04) and macroadenomas (33% vs 15% White, P = .05). At 3 months, remission rate was borderline higher in White (92% vs 78% Black, P = 0.08), which was attributed to macroadenomas by logistic regression. Conclusion We identified disparities regarding racial distribution, and clinical and biochemical characteristics in ACM, suggesting late or missed diagnosis in Black patients. Large nationwide studies are necessary to confirm our findings.
Zn–Al Layered Double Hydroxides Synthesized on Aluminum Foams for Fluoride Removal from Water

Fluoride excess in water represents an environmental issue and a risk for human health since it can cause several diseases, such as fluorosis, osteoporosis, and damage of the nervous system. Layered double hydroxides (LDHs) can be exploited to remove this contaminant from water by taking advantage of their high ion-exchange capability. LDHs are generally mixed with polluted water in the form of powders, which then cause the problem of uneasy separation of the contaminated LDH sludge from the purified liquid. In this work, Zn–Al LDH films were directly grown in situ on aluminum foams that acted both as the reactant and substrate. This method enabled the removal of fluoride ions by simple immersion, with ensuing withdrawal of the foam from the de-contaminated water. Different LDH synthesis methods and aluminum foam types were investigated to improve the adsorption process. The contact time, initial fluoride concentration, adsorbent dosage, and pH were studied as the parameters that affect the fluoride adsorption capacity and efficiency. The highest absorption efficiency of approximately 70% was obtained by using two separate growth methods after four hours, and it effectively reduced the fluoride concentration from 3 mg/L to 1.1 mg/L, which is below the threshold value set by WHO for drinking water.
Determining COVID-19 Dynamics Using Physics Informed Neural Networks

The Physics Informed Neural Networks framework is applied to the understanding of the dynamics of Coronavirus of 2019. To provide the governing system of equations used by the framework, the Susceptible-Infected-Recovered-Death mathematical model is used. The study focused on finding the patterns of the dynamics of the disease which involves predicting the infection rate, recovery rate and death rate; thus predicting the active infections, total recovered, susceptible and deceased at any required time. The study used data that was collected on the dynamics of COVID-19 from the Kingdom of Eswatini between March 2020 and September 2021. The obtained results showed less errors thus making highly accurate predictions.
Review of the Internal Structure, Psychometric Properties, and Measurement Invariance of the Work-Related Rumination Scale – Spanish Version

Background: The aim of the current study was to examine the internal structure and assess the psychometric properties of the Work-Related Rumination Scale (WRRS) – Spanish version in a Puerto Rican sample of workers. This instrument is a 15-item questionnaire, which has three factors, affective rumination, problem-solving pondering, and detachment. This measure is used in the occupational health psychology context; however, there is little evidence of its psychometric properties. Materials and Methods: A total sample of 4,100 from five different study samples was used in this cross-sectional study design in which the WRRS was used. We conducted confirmatory factor analysis (CFA) and exploratory structural equation modeling (ESEM) to examine the internal structure of the Work-Related Rumination Scale. Measurement invariance across sex and age was examined. Results: The three-factor model was supported; however, four items were eliminated due to their cross-loadings and factorial complexity. This 11-item Spanish version of the WRRS was invariant across sex and age. Reliability of the three-factors of WRRS were within the range of 0.74 to 0.87 using Cronbach’s alpha and McDonald’s omega. Correlations between the three factors were as expected as well as with other established measures. Conclusion: The results suggest that the WRRS-Spanish version appears to be a reliable and valid instrument to measure work-related rumination using its three factors. Comparison across sex and age appear to be useful in occupational health psychology research setting since results suggest that the WRRS is invariant regarding those variables.
Case history: electronically controlled fault current limiters allow inplant switchgear to be interconnected

The growth of industrial plant power systems, through either system interconnection or paralleling of generation, results in the increase of available short-circuit fault current, which can exceed the interrupting capacity of existing plant switchgear. Complete replacement of the switchgear may not be economical. As an alternative, a short-circuit current-limiting device can reduce the magnitude of fault current to an acceptable level. This paper reviews an actual installation of three three-phase electronically controlled fault current limiters (FCLs) in a pulp and paper mill. The FCLs allow three 12.5 kV 500 MVA switchboards to be interconnected with two 12.5 kV 750 MVA switchboards.
Clarifying the dimensions of four concepts of quality

There has long been a relationship between ergonomics and quality, ranging from studies of ergonomics and total quality management to ergonomic studies of service quality. However, quality is a concept that lacks a clear and concise definition and is thus difficult to accurately measure, improve, or even compare across different industries, products and services. To better understand the concept dimensions of quality, a three-phase study was conducted. All participants in the study were native English speakers and over the age of 18. Phase One consisted of a questionnaire, given to 80 participants, which resulted in a list of 254 words/phrases related to the perceptions of: (1) quality, (2) product quality, (3) service quality and (4) quality of life. Phase Two required a new set of 80 participants to rank each word as negatively or positively related to one of the four types of quality tested in Phase One. A smaller set of 30 words was selected for each concept for additional study. Phase Three, given to 40 unique participants, consisted of a pair-wise comparison experiment of all combinations of the subset of words related to each of the four types of quality. Phase Three resulted in groupings of words related to primary factors for each of the four concepts of quality examined. These word groupings can be used to develop definitions and scales for the various quality concepts, so that ergonomists have more user-based measures of this important variable.
Revisiting the Role of Leukocytes in Cystic Fibrosis

Cystic fibrosis in characterized by pulmonary bacterial colonization and hyperinflammation. Lymphocytes, monocytes/macrophages, neutrophils, and dendritic cells of patients with CF express functional CFTR and are directly affected by altered CFTR expression/function, impairing their ability to resolve infections and inflammation. However, the mechanism behind and the contribution of leukocytes in the pathogenesis of CF are still poorly characterized. The recent clinical introduction of specific CFTR modulators added an important tool not only for the clinical management of the disease but also to the investigation of the pathophysiological mechanisms related to CFTR dysfunction and dysregulated immunity. These drugs treat the basic defect in cystic fibrosis (CF) by increasing CFTR function with improvement of lung function and quality of life, and may improve clinical outcomes also by correcting the dysregulated immune function that characterizes CF. Measure of CFTR function, protein expression profiling and several omics methods were used to identify molecular changes in freshly isolated leukocytes of CF patients, highlighting two roles of leukocytes in CF: one more generally related to the mechanism(s) causing immune dysregulation in CF and unresolved inflammation, and another more applicative role, which identifies in myeloid cells, an important tool predictive of the therapeutic response of CF patients. In this review we will summarize available data on CFTR expression and function in leukocyte populations and will discuss potential clinical applications based on available data.
The Shaugh Moor Project: Fourth Report — Environment, Context and Conclusion

For five years from 1976 to 1980 the archaeology and environment of a block of landscape centred around Shaugh Moor on south-west Dartmoor were analysed prior to the destruction of some of the evidence by china clay working. The investigations began in 1976 with a survey of the field monuments and the initiation of soil, vegetation, small mammal and phosphate studies in addition to the search for peat deposits of sufficient antiquity. From 1977 the programme was determined by the encroachment of the quarries and other works, so that early in that year a group of cairns were excavated (site 10) and subsequently the first of two seasons work on a walled enclosure (site 15) was initiated. The excavation of the enclosure was completed in 1978 and in that year it was also necessary to undertake a small investigation near the northern edge of the project area on the Trowlesworthy cross-dyke (site 202) and near its southern edge on Wotter Playground (site 201). Settlements and field systems were surveyed and excavated on Wotter Common in 1979 and these investigations were completed in 1980 when the Saddlesborough Reave, which crosses the centre of the project area from east to west was also surveyed in detail and sampled by excavation. More field work could have been undertaken on threatened areas and indeed a limited operation was undertaken in 1981 on the Saddlesborough Reave to confirm some points of detail. Instead, it was thought best to conclude the project after five years, to complete the publication of the results and to allow mature consideration of these so as to generate a new set of questions. At an early stage the decision was taken to publish the work as a series of annual reports in these Proceedings rather than as a single monograph. The first report (Wainwright et al. 1979) set out the simple research design for the project and contained accounts of the 1976 survey and of the excavation of the cairn group.
Contrasting Hydraulic Efficiency and Photosynthesis Strategy in Differential Successional Stages of a Subtropical Forest in a Karst Region

Understanding the successional process from a disturbed forest to a mature forest is essential for species recovery and conservation initiatives. The resource acquisition and drought tolerance of plants can be instructive to predictions of species abundance and distribution for different forests. However, they have not been adequately tested at different successional stages in karst regions. Here, we selected seven dominant species in an early-succession forest and 17 species in a late-succession forest in a karst region of southwestern China. Resource acquisition-related traits such as hydraulic conductivity and photosynthetic rate, and drought tolerance-related traits, including turgor loss point and wood density, were measured. We found that species in the early-succession forest had a higher hydraulic conductance and photosynthetic rate than those in the late-succession forest, while leaf water potential at turgor loss point and wood density showed nonsignificant differences between the two forests. In addition, we observed a significant negative relationship between photosynthetic rate and drought tolerance in the early-succession forest, which was not identified in late-succession forests. Our study indicates that resource acquisition rather than drought tolerance was the key factor explaining plant distributions in forests at different successional stages in karst regions. We also suggest that the resource acquisition and drought tolerance trade-off hypothesis is not always supported for karst region species. Our study could inform about the design of species replacements in successional forests and provide forest management and restoration guidelines for karst regions.
Transdermal Drug Delivery in the Pig Skin

Transdermal delivery can be accomplished through various mechanisms including formulation optimization, epidermal stratum corneum barrier disruption, or directly by removing the stratum corneum layer. Microneedling, electroporation, a combination of both and also the intradermal injection known as mesotherapy have proved efficacy in epidermal-barrier disruption. Here we analyzed the effects of these methods of epidermal-barrier disruption in the structure of the skin and the absorption of four compounds with different characteristics and properties (ketoprofen, biotin, caffein, and procaine). Swine skin (Pietrain x Durox) was used as a human analogue, both having similar structure and pharmacological release. They were biopsied at different intervals, up to 2 weeks after application. High-pressure liquid chromatography and brightfield microscopy were performed, conducting a biometric analysis and measuring histological structure and vascular status. The performed experiments led to different results in the function of the studied molecules: ketoprofen and biotin had the best concentrations with intradermal injections, while delivery methods for obtaining procaine and caffein maximum concentrations changed on the basis of the lapsed time. The studied techniques did not produce significant histological alterations after their application, except for an observed increase in Langerhans cells and melanocytes after applying electroporation, and an epidermal thinning after using microneedles, with variable results regarding dermal thickness. Although all the studied barrier disruptors can accomplish transdermal delivery, the best disruptor is dependent on the particular molecule.
Structure of the Cell-Wall-Associated Polysaccharides from the Deep-Sea Marine Bacterium Devosia submarina KMM 9415T

Two cell-wall-associated polysaccharides were isolated and purified from the deep-sea marine bacterium Devosia submarina KMM 9415T, purified by ultracentrifugation and enzymatic treatment, separated by chromatographic techniques, and studied by sugar analyses and NMR spectroscopy. The first polysaccharide with a molecular weight of about 20.7 kDa was found to contain d-arabinose, and the following structure of its disaccharide repeating unit was established: →2)-α-d-Araf-(1→5)-α-d-Araf-(1→. The second polysaccharide was shown to consist of d-galactose and a rare component of bacterial glycans-d-xylulose: →3)-α-d-Galp-(1→3)-β-d-Xluf-(1→.
Student Performance in a Large First Year Economics Subject: Which Variables are Significant?

The first year experience at university and issues relating to retention rates continue to attract the attention of educationalists. This article investigates the relative importance of a wide range of variables that may impact student performance at the first year level. The multiyear data set covers 2187 students who are enrolled in an introductory economics subject at a major multicampus university. The significant variables detected may assist those currently trying to raise retention rates and raise some questions about the capacity of universities to successfully increase their enrolment rates significantly in the future. Copyright (c) 2010 The Economic Society of Australia.
Factors Considered When Making Corn Foliar Fungicide Application Decisions in Illinois

Foliar fungicide use on corn in Illinois has increased drastically beginning in 2007. In an effort to better understand the factors considered in corn fungicide application decisions, attendees of a series of meetings in Illinois were surveyed. Results indicate that disease pressure was the most important factor considered by the greatest percentage of survey respondents (38%). Factors not related to disease or disease risk were considered the most important factor for 23% of the respondents. These results indicate that additional Extension programming is needed to teach the importance of considering disease and disease risk when making a fungicide decision.
Optical low coherence method for characterizing silica-based arrayed-waveguide grating multiplexers

We describe a powerful method for the precise measurement of optical path phase errors and power-distribution coefficients in silica-based arrayed-waveguide grating multiplexers through the use of Fourier transform spectroscopy. The theoretical accuracies for measuring these parameters are /spl plusmn/1/spl deg/ and /spl plusmn/5%, respectively, when the geometrical step increment of the arrayed waveguides is greater than 48 /spl mu/m. The method reveals the random distributions of optical path phase errors in two multiplexers with channel spacings of 100 and 10 GHz, and proves that these distributions are the main origins of the channel crosstalk. The method predicts that when optical path phase errors are sufficiently reduced, the channel crosstalk values will decrease to -39 and -29 dB, respectively, and these limits are due to slightly deformed power distributions.
Design of four‐channel diplexer using distributed coupling technique

Distributed coupling technique and two pairs of stepped‐impedance resonators are used to realize a four‐channel diplexer. Due to the low loading effect of distributed coupling technique, the proposed circuit can design many channels without the use of complicated matching network. Each pairs of resonators is designed for a dual‐band performance achieving a compact size. © 2016 Wiley Periodicals, Inc. Microwave Opt Technol Lett 58:166–170, 2016
Transmission efficiency and noise, vibration and harshness refinement of differential hypoid gear pairs

This article presents a combined multi-body dynamics and lubricated contact mechanics model of vehicular differential hypoid gear pairs, demonstrating the transient nature of transmission efficiency and noise, vibration and harshness performance under various driving conditions. The contact of differential hypoid gears is subjected to mixed thermo-elastohydrodynamic regime of lubrication. The coefficient of friction is obtained using an analytical approach for non-Newtonian lubricant shear and supplemented by boundary interactions for thin films. Additionally, road data and aerodynamic effects are used in the form of resisting torque applied to the output side of the gear pair. Sinusoidal engine torque variation is also included to represent engine order torsional input resident on the pinion gear. Analysis results are presented for New European Driving Cycle transience from low-speed city driving condition in second gear to steady-state cruising in fourth gear for a light truck. It is shown that the New European Driving Cycle captures the transmission efficiency characteristics of the differential hypoid gear pair under worst case scenario, with its underlying implications for fuel efficiency and emissions. However, it fails to address the other key attribute, being the noise, vibration and harshness performance. In the case of hypoid gears, the resultant noise, vibration and harshness characteristics can be particularly annoying. It is concluded that broader transient manoeuvres encompassing New European Driving Cycle are required for assessment, in order to obtain a balanced approach for transmission efficiency and noise, vibration and harshness performance. This approach is undertaken in this article, which is not hitherto reported in the literature.
Sensitivity to Emotion Intensity and Recognition of Emotion Expression in Neurotypical Children

This study assessed two components of face emotion processing: emotion recognition and sensitivity to intensity of emotion expressions and their relation in children age 4 to 12 (N = 216). Results indicated a slower development in the accurate decoding of low intensity expressions compared to high intensity. Between age 4 and 12, children discriminated high intensity expressions better than low ones. The intensity of expression had a stronger impact on overall face expression recognition. High intensity happiness was better recognized than low intensity up to age 11, while children 4 to 12 had difficulties discriminating between high and low intensity sadness. Our results suggest that sensitivity to low intensity expressions acts as a complementary mediator between age and emotion expression recognition, while this was not the case for the recognition of high intensity expressions. These results could help in the development of specific interventions for populations presenting socio-cognitive and emotion difficulties.
Lipid signatures reflect the function of the murine primary placentation

Abstract The placenta regulates maternal-fetal communication, and its defect leads to significant pregnancy complications. The maternal and embryonic circulations are primitively connected in early placentation, but the function of the placenta during this developmentally essential period is relatively unknown. We thus performed a comparative proteomic analysis of the placenta before and after primary placentation and found that the metabolism and transport of lipids were characteristically activated in this period. The placental fatty acid (FA) carriers in specific placental compartments were upregulated according to gestational age, and metabolomic analysis also showed that the placental transport of FAs increased in a time-dependent manner. Further analysis of two mutant mice models with embryonic lethality revealed that lipid-related signatures could reflect the functional state of the placenta. Our findings highlight the importance of the nutrient transport function of the primary placenta in the early gestational period and the role of lipids in embryonic development. Summary Sentence The placenta is activated characteristically in terms of lipid transport during primary placentation, and the lipid-related signatures closely reflect the functional state of the placenta.