Miracle-dz/UniFAR-FTUs huggingface dataset:
Conversion of Unmodified Stem Cells to Pacemaker Cells by Overexpression of Key Developmental Genes

Arrhythmias of the heart are currently treated by implanting electronic pacemakers and defibrillators. Unmodified adipose tissue-derived stem cells (ASCs) have the potential to differentiate into all three germ layers but have not yet been tested for the generation of pacemaker and Purkinje cells. We investigated if—based on overexpression of dominant conduction cell-specific genes in ASCs—biological pacemaker cells could be induced. Here we show that by overexpression of certain genes that are active during the natural development of the conduction system, the differentiation of ASCs to pacemaker and Purkinje-like cells is feasible. Our study revealed that the most effective procedure consisted of short-term upregulation of gene combinations SHOX2-TBX5-HCN2, and to a lesser extent SHOX2-TBX3-HCN2. Single-gene expression protocols were ineffective. Future clinical implantation of such pacemaker and Purkinje cells, derived from unmodified ASCs of the same patient, could open up new horizons for the treatment of arrythmias.
New records and observations of marine algae from Morocco (Eastern Atlantic Ocean)

ABSTRACT In the present paper, three algal species are recorded for the first time from Morocco: the two red algae Antithamnion villosum and Antithamnionella ternifolia and the green alga Lychaete rhodolithicola. Furthermore, two other red algae species are recorded for the first time from the Moroccan Atlantic coast and this part of the eastern Atlantic Ocean: Antithamnion amphigeneum and Antithamnionella boergesenii. Descriptions of these newly reported species are provided accompanied by photographs for each species. In addition, new observations and taxonomic remarks for some species are also provided. The green alga Lychaete rhodolithicola has a limited distribution in the North-eastern Atlantic Ocean of Europe, and the report of this species from Morocco extends the distribution of this species, because it is the first record of this species in Africa and outside Europe. This is one of the rare documentations with description and illustrations of L. rhodolithicola. The foliose species Grateloupia turuturu is studied in detail; it has been widely misidentified as G. doryphora. An examination of all specimens going under the name G. doryphora in the Moroccan herbaria has determined these specimens to be Grateloupia turuturu. An identification key for all Moroccan species of Antithamnion, Antithamnionella and Lychaete is presented.
Perceived intrusiveness, consumer attention, and intent to purchase: The moderating effect of celebrity preferences

This study aims to investigate the moderating effect of celebrity preferences on the relationship between perceived intrusiveness, consumer attention, and intent to purchase by applying Stimulus-Organism-Responds (SOR) Theory as a foundation. A total of 310 questionnaires were used in this study. This study uses the Structural Equation Modelling (SEM) Analysis approach by dividing a sample into two groups: (1) preference and (2) non-preference. A total of 155 samples filled out advertisements that matched respondents’ preferences and 155 samples filled out advertisements that did not match respondents’ preferences. The finding of this study are: (a) perceived intrusiveness is negatively affects consumer attention, (b) consumer attention positively affect intent to purchase, (c) celebrity preference moderates the effect of perceived intrusiveness on consumer attention, in a way that the higher celebrity preference will reduce the effect of perceived intrusiveness on consumer attention, and (d) celebrity preference moderates the influence of consumer attention on intent to purchase, in a way that the higher celebrity preference will strengthen the influence of consumer attention on intent to purchase. This finding could indicate the presence of intrusive advertising if the ad matches the preferences of the audience, then the ad will still get the attention of the audience and even affect the consumer's intention to buy.
Development of an Epidemic‐Type Aftershock‐Sequence Model Explicitly Incorporating the Seismicity‐Triggering Effects of Slow Slip Events

Slow slip events (SSEs) at subduction zone plate boundaries sometimes trigger earthquake swarms and megathrust earthquakes. The causal relationship between SSEs and seismicity has been studied worldwide, but the epidemic‐type aftershock‐sequence (ETAS) model, which is a standard statistical model of seismicity, does not explicitly consider the seismicity‐triggering effect of SSEs. Therefore, if an SSE occurs at a plate boundary, probabilistic earthquake forecasts based on the ETAS model fail to predict observed seismicity. Here, we constructed a statistical model named the SSE‐modulated ETAS model by incorporating SSE moment rates estimated from observation data from the global navigation satellite system into the original ETAS model. Our model assumes a linear or power‐law relationship between the SSE moment rates and seismicity rates and estimates its proportionality constant as a new ETAS parameter. We applied this new model to three SSEs and M 2.5 or greater earthquakes in the shallow part of the Hikurangi Trench, New Zealand. The results show that it is better than the original ETAS model, giving a significant reduction in the Akaike information criterion. In addition, we examined the functional forms (e.g., lag time and power exponent) of the equation relating the moment rate of the SSEs to the seismicity rate. We also examine the influence of SSEs on aftershock productivity. Our model can improve short‐term forecasts of seismicity associated with SSEs if the detection and characterization of SSEs can be done in near real time. Our model is also useful for quantifying characteristics of SSE‐induced seismicity.
Planned parathyroidectomy: the new standard in hypercalcemic crisis

ABSTRACT Objective: The study sought to determine the clinical features of hyperparathyroid-induced hypercalcemic crisis (HIHC) along with treatment options and outcomes. Subjects and methods: This is a retrospective analysis of our historical cohort of patients with primary hyperparathyroidism (PHPT). Patients were divided in groups according to their calcium levels and clinical presentation. HIHC (group 1) was assumed when patients had high calcium levels and needed emergency hospitalization. Group 2 was composed of patients with calcium levels above 16 mg/dL or patients who needed hospitalization for classical PHPT symptoms. Group 3 was composed of clinically stable patients with calcium levels between 14 and 16 mg/dL, who were electively treated. Results: Twenty-nine patients had calcium levels above 14 mg/dL. HIHC group had seven patients, and initial clinical measures had good response in two patients, moderate response in one patient, and poor response in four patients. All poor responders underwent immediate surgery, and one of them died due to HIHC complications. Group 2 had nine patients, and all were successfully treated during hospitalization. Group 3 had 13 patients, and all had a successful elective surgery. Conclusion: HIHC is a life-threatening condition that requires fast clinical intervention. Surgery is the only definitive treatment and should be planned for all patients. Poor response to initial clinical measures should direct treatment toward surgery to avoid disease progression and clinical deterioration.
Monotonicity of certain functionals under rearrangement

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Evaluation and Comparison of Reversible Water Electrolysis as a Means for Pneumatic Actuation

This work presents an evaluation of reversible water electrolysis as a method for pneumatic actuation via the electrochemical decomposition of water into hydrogen and oxygen gas. In addition to a theoretical evaluation of the performance of electrochemically-driven pressurized hydrogen generation, pneumatic generation methods were experimentally tested across two axes: performance and compatibility. Through these experiments, the achievable pressure was shown to be at least 0.75 MPa gauge with a flow rate of 0.06 [L/min]. It was also determined that negligible losses were incurred due to switching from air to hydrogen. Despite low experimental round-trip efficiencies of 0.005%, the reversible electrolysis of water reaction was shown to be a feasible method for pneumatic actuation of soft robots, especially under scenarios where actuator bandwidth is not of concern.
Generational differences in values and patterns of thinking in the workplace

The aim of this article is to empirically identify and analyse the differences between generations X, Y and Z in terms of values and patterns of thinking in the workplace. For the purposes of achieving the set objective, quantitative studies were performed. Data were obtained with the use of the MindSonar psychometric test. The results were subjected to a statistical analysis, and 435 economically active respondents took part in the study. The study shows that there are numerous statistically significant differences in preferred values and patterns of thinking among representatives of various generations (the differences occur in 2 out of the 7 measured levels of existence and their corresponding values, and in 9 out of the 32 measured patterns of thinking, or metaprograms). The obtained results may help HR managers and specialists focus on real, diagnosed differences in employees, which may be used for determining and communicating organisational priorities for current and future employees.
Giant magnetoresistance due to magnetoelectric currents in Sr3Co2Fe24O41 hexaferrites

The giant magnetoresistance and magnetoelectric (ME) effects of Z-type hexaferrite Sr3Co2Fe24O41 were investigated. The present experiments indicated that an induced magnetoelectric current in a transverse conical spin structure not only presented a nonlinear behavior with magnetic field and electric field but also depended upon a sweep rate of the applied magnetic field. More interestingly, the ME current induced magnetoresistance was measured, yielding a giant room temperature magnetoresistance of 32.2% measured at low magnetic fields (∼125 Oe). These results reveal great potential for emerging applications of multifunctional magnetoelectric ferrite materials.
Evaluating the Coverage and Depth of Latent Dirichlet Allocation Topic Model in Comparison with Human Coding of Qualitative Data: The Case of Education Research

Fields in the social sciences, such as education research, have started to expand the use of computer-based research methods to supplement traditional research approaches. Natural language processing techniques, such as topic modeling, may support qualitative data analysis by providing early categories that researchers may interpret and refine. This study contributes to this body of research and answers the following research questions: (RQ1) What is the relative coverage of the latent Dirichlet allocation (LDA) topic model and human coding in terms of the breadth of the topics/themes extracted from the text collection? (RQ2) What is the relative depth or level of detail among identified topics using LDA topic models and human coding approaches? A dataset of student reflections was qualitatively analyzed using LDA topic modeling and human coding approaches, and the results were compared. The findings suggest that topic models can provide reliable coverage and depth of themes present in a textual collection comparable to human coding but require manual interpretation of topics. The breadth and depth of human coding output is heavily dependent on the expertise of coders and the size of the collection; these factors are better handled in the topic modeling approach.
Transcending the ‘End of War’ Debate: Toward a Mechanism-Centered View on the ‘War on War'

Has war become obsolete? Some argue that macro-historical social processes are leading war into obsolescence, while for others that pattern is explained by the fact that war is a lingering potential outcome of international politics. I argue that both answers reveal a fundamental problem with the debate about the ‘end of war’. The focus on securing predictions about the end of war keeps analyses trapped in either a teleological or nomothetical linearity and overshadows the varied set of contingent mechanisms that allow for non-violent outcomes to prevail in contentious political episodes. The ‘War on War’ could benefit from analyses that asses shifting configurations of mechanisms in power politics.
Improving Collaboration with Culturally and Linguistically Diverse Parents of Students with Extensive Support Needs

The purpose of this research is to understand how to improve collaboration between schools and culturally and linguistically diverse parents of students with extensive support needs who receive special education services. Previous research defined collaboration as a conceptual construct in which principles of shared respect and responsibility are applied to practice (Emmons & Zager, 2018). The collaboration between families and schools is legally mandated but not explicitly explained to teachers or parents how to succeed in engaging respectfully with all families (Cheatham & Lim-Mullins, 2018). The increased complication of supporting nondominant, culturally and linguistically diverse families in addition to the complexity of extensive support needs of many students in special education add additional barriers to successful and balanced collaboration (Harry, 2008). The reviewed research does not address the multifaceted aspects of collaboration and how CLD parents struggle to feel like an integral part of the team, especially those parents of students with extensive support needs (Olivos, Gallagher, & Aguilar, 2010). The goal for this study was to understand how to achieve equitable collaboration that improves student outcomes. This qualitative study surveyed five Spanish speaking parents (four women and one man) and eleven teachers (four men and seven women) and included interviews with two parents (one man and one woman), all from the same non-public school. The findings document how collaboration is defined by parents and teachers and that communication is a building block for collaboration. Findings also highlight barriers to collaboration and effective strategies for equitable collaboration. This project’s findings are significant in that there are implications for equity of collaboration between parents and schools with a concentrated focus on the CLD parents of students with extensive support needs.
Online Extensive Reading: A Friend or Foe

The study looked into the perceptions of EFL instructors working at schools of foreign languages at various universities throughout Turkey in order to better understand the effects of Online Extensive Reading (OER) on language learning and the difficulties regarding its implementation. A mixed-type descriptive study design was used to achieve the aim of the study, and the data were collected through semi-structured interviews and an online questionnaire. The questionnaire was completed by 181 EFL instructors, and 10 of them took part in the interviews. The quantitative data analysis was performed via SPSS.23 and frequencies and percentages were calculated. The qualitative data analysis which resulted in the formation of various themes and codes was carried out via MAXQDA. The results revealed that while the instructors held favourable perceptions towards the effects of OER on language learning including its benefits on reading, writing, and vocabulary, they were worried about certain difficulties including hectic schedules, student motivation, school curriculums, exams, and their technical expertise. Overall, it was concluded that despite the instructors' favourable perceptions of OER, it is not a practice that is frequently used in higher education in Turkey due to the instructors' lack of knowledge of OER and the difficulties they mentioned.
Results on SARS-CoV-2 mRNA Vaccine Booster from an Open-Label Multicenter Study in Ofatumumab-Treated Participants with Relapsing Multiple Sclerosis

Background: Few data exist on how ofatumumab treatment impacts SARS-CoV-2 booster vaccination response. Methods: KYRIOS is an ongoing prospective open-label multicenter study on the response to initial and booster SARS-CoV-2 mRNA vaccination before or during ofatumumab treatment in relapsing MS patients. The results on the initial vaccination cohort have been published previously. Here, we describe 23 patients who received their initial vaccination outside of the study but booster vaccination during the study. Additionally, we report the booster results of two patients in the initial vaccination cohort. The primary endpoint was SARS-CoV-2-specific T-cell response at month 1. Furthermore, serum total and neutralizing antibodies were measured. Results: The primary endpoint was reached by 87.5% of patients with booster before (booster cohort 1, N = 8) and 46.7% of patients with booster during ofatumumab treatment (booster cohort 2, N = 15). Seroconversion rates for neutralizing antibodies increased from 87.5% at baseline to 100.0% at month 1 in booster cohort 1 and from 71.4% to 93.3% in booster cohort 2. Of note, 3 of 4 initially seronegative patients in booster cohort 2 and one seronegative patient in the initial vaccination cohort seroconverted after the booster during ofatumumab treatment. Conclusions: Booster vaccinations increase neutralizing antibody titers in ofatumumab-treated patients. A booster is recommended in ofatumumab-treated patients.
THE MEDIATING ROLE OF INFORMATION LEAKAGE ON THE RELATIONSHIP BETWEEN SUPPLY CHAIN INFORMATION INTEGRATION AND OPERATIONAL PERFORMANCE

This existing study aimed at investigating indirect effects of leakage of information on supply chain and operational performance. Nature of this study is quantitative and nature of data was cross-sectional. Primary data was collected through questionnaire. Population of this study comprised of organizations’ directors, managers. Snow ball sampling technique was used to select sample. Total 250 questionnaires were distributed and total 152 questionnaires were received which were then used in the analysis of data inSPSS. The response rate was 60.8%. Cronbach alpha and exploratory factor analysis (EFA) was used to test reliability and validity of the questionnaire. Mediation analysis was run in process file using resample rate of 5000 bootstrapping at 95% confidence interval. Cronbach alpha and factors loadings met the threshold. Information leakage mediated between supply chain and operational performance. It was also evident from the indirect effects that information leak could have worse effects on supply chain and operational performance. It is concluded that leak of information whether intentional or accidental both have effect on operational performance. It is therefore mandatory for professionals to take great care while dealing with supply chain partners so that it may not affect their performance. Managers have to raise awareness to secure the information confidential and to maintain secrecy. Doors for further research are open for professionals, scholars and academicians. They may add other variables in this model and extend the body of knowledge of supply chain, operational performance and leak of information.
On subgrid-scale physics in the convective atmospheric surface layer

The dynamics of the subgrid-scale (SGS) stress and scalar flux in the convective atmospheric surface layer are studied using field measurements from the Advection Horizontal Array Turbulence Study (AHATS). We extend the array technique previously used to evaluate the SGS velocity and temperature to include measurements of the fluctuating pressure, enabling separation of the resolvableand subgrid-scale pressure and allowing for the first-ever observations of the pressure covariance terms and the full SGS budgets. Non-dimensional forms of the budget terms are analysed as functions of the surface-layer stability parameter, z/L, and the ratio of the wavelength of the spectral peak of the vertical velocity to the filter width, Λw/∆f , a measure of the largeeddy simulation (LES) fidelity. Analyses of the mean SGS turbulence kinetic energy budget show a balance among the production, transport, and dissipation. The mean SGS shear stress and SGS temperature flux budgets, meanwhile, are dominated by the production and pressure destruction, with the latter causing return to isotropy. The budgets of the normal components of the SGS stress are more complex. Most notably the pressure–rate-of-strain includes two competing processes, return to isotropy and generation of anisotropy, the latter due to ground blockage of the large-scale convective eddies. For neutral surface layers, return to isotropy dominates. For unstable surface layers return to isotropy dominates for small filter widths, whereas for large filter widths the ground blockage effect dominates, resulting in strong anisotropy. Analyses of the terms in the budgets of the conditional mean SGS stress and SGS scalar flux, which must be correctly predicted by the SGS model in order for LES to reproduce the resolvablescale velocity and temperature probability density functions, further reveal the complex dependence of the SGS pressure–rate-of-strain on the updrafts generated by buoyancy, downdrafts associated with the returning flow, and wall blocking effects. Under conditions of strong convective instability, the results most notably show conditional pressure redistribution from the (smaller) vertical to the
Teamwork Management and Benefit of Telemedicine in COVID-19 Outbreak Control on an Offshore Vessel in the Gulf of Thailand, Songkhla Province, Thailand: A Case Report

In May 2021, there was a COVID-19 outbreak on board a construction support ship traveling from India to Thailand. Controlling the outbreak on this offshore vessel from 11 May to 2 June 2021 was applied. This case report describes the teamwork management of COVID-19 control on the vessel in the Gulf of Thailand. We summarized the COVID-19 outbreak control process on board, including active COVID-19-infected cases (CoIC) and close contacts (CoCC) identification, isolation, quarantine, treatment, and clinical monitoring using telemedicine to report their health measurements twice daily, including emergency conditions if they occurred. Active COVID-19 cases were identified by two rounds of reverse transcription polymerase chain reaction (RT-PCR) tests in all crew members, in which 7 of 29 (24.1%) showed positive results. Both the CoIC and CoCC were strictly and absolutely isolated and quarantined on the vessel. No serious medical conditions were reported during the monitoring. The third-round RT-PCR tests were conducted, and all tested negative one week later. Teamwork management in proactive COVID-19 case identification, isolation, comprehensive treatment, and close monitoring of health conditions using telemedicine devices is beneficial for controlling the COVID-19 outbreak on board.