Miracle-dz/UniFAR-FTUs huggingface dataset:
Management of Advanced Peri-Implantitis by Guided Bone Regeneration in Combination with Trabecular Metal Fixtures, Two Months after Removal of the Failed Implants: Two-Year Results of a Single-Cohort Clinical Study

Background: Implant replacement is among the treatment options for severe peri-implantitis. The aim of this single-cohort study was to evaluate the feasibility of replacing compromised implants affected by advanced peri-implantitis with new implants with a porous trabecular metal (TM) structure. Materials and Methods: Patients with one or more implants in the posterior region showing a defect depth >50% of implant length, measured from the residual crest, were consecutively included. Two months after implant removal, patients received a TM implant combined with a xenograft and a resorbable membrane. The implant stability quotient (ISQ) was measured at placement and re-assessed five months later (at uncovering), then after 6, 12, and 24 months of function. Marginal bone loss was radiographically evaluated. Results: Twenty consecutive cases were included. One patient dropped out due to COVID-19 infection, and nineteen cases were evaluated up to 24 months. At placement, the mean ISQ was 53.08 ± 13.65 (standard deviation), which increased significantly to 69.74 ± 9.01 after five months of healing (p < 0.001) and to 78.00 ± 7.29 after six months of loading (p < 0.001). Thereafter, the ISQ remained stable for up to 24 months (80.55 ± 4.73). All implants successfully osseointegrated and were restored as planned. After two years, the average marginal bone level change was −0.41 ± 0.38 mm (95% confidence interval −0.60, −0.21), which was limited yet significantly different from the baseline (p < 0.05). Conclusions: The treatment of advanced peri-implant defects using TM implants inserted two months after explantation in combination with guided bone regeneration may achieve successful outcomes up to two years follow-up, even in the presence of low primary stability.
Oxidative Stress Plays an Important Role in Glutamatergic Excitotoxicity-Induced Cochlear Synaptopathy: Implication for Therapeutic Molecules Screening

The disruption of the synaptic connection between the sensory inner hair cells (IHCs) and the auditory nerve fiber terminals of the type I spiral ganglion neurons (SGN) has been observed early in several auditory pathologies (e.g., noise-induced or ototoxic drug-induced or age-related hearing loss). It has been suggested that glutamate excitotoxicity may be an inciting element in the degenerative cascade observed in these pathological cochlear conditions. Moreover, oxidative damage induced by free hydroxyl radicals and nitric oxide may dramatically enhance cochlear damage induced by glutamate excitotoxicity. To investigate the underlying molecular mechanisms involved in cochlear excitotoxicity, we examined the molecular basis responsible for kainic acid (KA, a full agonist of AMPA/KA-preferring glutamate receptors)-induced IHC synapse loss and degeneration of the terminals of the type I spiral ganglion afferent neurons using a cochlear explant culture from P3 mouse pups. Our results demonstrated that disruption of the synaptic connection between IHCs and SGNs induced increased levels of oxidative stress, as well as altered both mitochondrial function and neurotrophin signaling pathways. Additionally, the application of exogenous antioxidants and neurotrophins (NT3, BDNF, and small molecule TrkB agonists) clearly increases synaptogenesis. These results suggest that understanding the molecular pathways involved in cochlear excitotoxicity is of crucial importance for the future clinical trials of drug interventions for auditory synaptopathies.
Dynamics and Aerodynamic Control of a Cross-Track Tether Satellite System

The objective of this paper is to present and analyze the dynamics and control strategy of a novel type of formation flight architecture, that could enable unprecedented space mission capabilities. In particular we propose and study a tether satellite system composed by two or more satellites, flying in LEO, connected by a linear tether. That tether is maintained in tension along the cross-track direction, with respect to the orbit, i.e., perpendicular to the motion and radial directions, by exploiting the aerodynamic lift acting upon the suitably oriented satellites. Possible applications of this formation are related, in particular, to remote sensing. To carry out the study, a three-dimensional multibody model was developed, introducing the equations of relative dynamics centered in an orbiting reference frame. To simulate the conditions of low Earth orbit, several mathematical models taken from the literature were used, in order to include the Earth’s gravitational potential up to fourth order, solar pressure, third-body perturbations, atmospheric drag and the behavior of aerodynamic surfaces in a free molecular flow. By utilizing this model and verifying that this configuration is intrinsically unstable, it was concluded that the system needs continuous control to be stabilized. As a result, the model of the dynamics was linearized and an optimal LQR controller was introduced to calculate the force required to hold the system in place. Once the linear control law was validated by simulating its application on the full system model, aerodynamic surfaces were next introduced in order to generate the force required for control by taking advantage of the rarefied atmosphere of low Earth orbit. The proposed control strategy is tested by extensive numerical simulations. Finally, the proposed aerodynamic stabilization approach to continuously maintain a linear tether satellite system along the cross-track direction was compared to a gyroscopic stabilization alternative strategy. This strategy consists of putting the system into rotation in a direction perpendicular to the cross-track direction. The centrifugal force generated by the rotation stabilizes the system, maintaining constant oscillations in the cross-track direction throughout the orbit. Both cases have been analyzed as the size of the system and the number of satellites change.
Exploring COVID-19 Vaccination Willingness in Italy: A Focus on Resident Foreigners and Italians Using Data from PASSI and PASSI d’Argento Surveillance Systems

(1) The COVID-19 pandemic exacerbated health disparities, both between foreign and autochthonous populations. Italy was one of the European countries that was the most affected by the COVID-19 pandemic; however, only limited data are available on vaccine willingness. This study aims to assess the propensity of foreign and autochthonous populations residing in Italy to be vaccinated and the relative associated factors. (2) Data were collected and analysed from the two Italian surveillance systems, PASSI and PASSI d’Argento, in the period of August 2020–December 2021. The data include those of the Italian resident adult population over 18 years old. A multinomial logistic regression model, stratified by citizenship, was used to assess the associations of sociodemographic, health, and COVID-19 experience variables with vaccination attitudes. (3) This study encompassed 19,681 eligible subjects. Considering the willingness to be vaccinated, foreign residents were significantly less certain to get vaccinated (49.4% vs. 60.7% among Italians). Sociodemographic characteristics, economic difficulties, and trust in local health units emerged as factors that were significantly associated with vaccine acceptance. Having received the seasonal flu vaccine was identified as a predictor of COVID-19 vaccine acceptance among foreign and Italian residents. (4) This study underscores the significance of tailoring interventions to address vaccine hesitancy based on the diverse characteristics of foreign and Italian residents. This research offers practical insights for public health strategies, highlighting the importance of tailored educational campaigns, improved communication, and nuanced interventions to enhance vaccine acceptance and uptake within both populations.
A Retrospective Analysis of Dynamic Compression Plating Versus Intramedullary Nailing for the Management of Shaft of Humerus Fractures in an Urban Trauma Care Center

Introduction There is constant debate regarding the best surgical technique for the fixation of shaft humerus fractures. Intramedullary nailing and dynamic compression plating are the most popular surgical options. Materials and methods In our study, we retrospectively analyze the results of 27 patients with shaft humerus fractures managed with intramedullary nailing (10) and dynamic compression plating (17) at our institute from September 2021 to October 2022. Preoperative clinical assessment sheets, postoperative follow-up sheets, operative notes, anesthesia sheets, and preoperative and follow-up radiographs were analyzed. Reamed antegrade nailing was done in all cases, while dynamic compression plating was done through a posterior approach. Results The operative time of the nailing group was 82.1 ± 7.61 mins, which was significantly lesser (P value <0.05) than that of the plating group, which was 119.59 ± 10.16 mins. The intraoperative blood loss of the patients who were managed with nailing was 71 ± 7.38 mL, which was significantly lesser (P value <0.05) than that of the plating group, which was 130.59 ± 11.44 mL. The patients in both groups had a statistically nonsignificant difference in terms of functional results, which were assessed using Rodriguez-Merchan criteria. Complications were similar in both groups with infection (17.65%), and postoperative radial nerve palsy (11.76%) was more common among the patients undergoing plating, and shoulder impingement(20%) was common among those undergoing nailing. Conclusion This study concluded that both surgical options are similar in the case of functional results. The selection of the surgical method should be as per the surgeon's surgical familiarity and personalized to individual patients.
Effect of Compost Combination on Methane Emission in Undisturbed Acid Sulphate soil in South Kalimantan of Indonesia

A greenhouse experiment was conducted to examine the cumulative methane (CH4) emission in paddy soils and correlation with soil redox potential (Eh), soil pH and plant growth. The experiment was arranged in two factorial randomized block designs with three replications. The first factor was a kind of of organic matter, i.e. without organic matter (T0), combination of 50% of composted straws and 50% composted rush weed (T1), combination of 30% of composted straws and 30% composted rush weed and 40% composted cattle manure (T2) and the second factor was the management of water that was continuously flooded and leaching. The methane emission was measured in South Kalimantan using the chamber and gas chromatogram technique. The results showed methane emission in undisturbed acid sulphate soil ranged from 0.05 to 0.32 mg CH4.m-2.minute-1 during the rice-growing season. The methane emission from the paddy soil were lower when the paddy was drained than when it was flooded. Correlation analysis showed a negative relation between methane emission and soil redox potential (Eh) and soil pH in both water management. The rice plant height and number of buds has positively correlation with methane emission with coeffecient correlation of r=0.84**(P<0.0001) and r=0.64**(P=0.004), respectively. Normal 0 false false false IN X-NONE X-NONE [ How to Cite : Wahida A and A Maas. 2015. Effect of Compost Combination on Methane Emission in Undisturbed Acid Sulphate soil in South Kalimantan of Indonesia. J Trop Soils 20: 135-141. Doi: 10.5400/jts.2015. 20.3. 135 ]
Multidrug-Resistant Commensal and Infection-Causing Staphylococcus spp. Isolated from Companion Animals in the Valencia Region

Simple Summary The increase in microorganisms resistant to antimicrobials poses a growing risk to the effectiveness of medical treatments, both in humans and animals. This surveillance is essential to understand and address the magnitude of the problem and its impact on public health. Therefore, it is crucial to monitor antimicrobial resistance not only in human medicine but also in veterinary medicine. Companion animals, in particular, play a significant role as they live in close contact with their owners, potentially facilitating the transmission of these antimicrobial resistance between people and animals. Thus, this study aimed to evaluate the epidemiological situation of antimicrobial resistance in dogs and cats to the opportunistic pathogen Staphylococcus spp. The main results showed a high prevalence of antimicrobial resistance in the study population (healthy and diseased dogs and cats), even to the last resort of antibiotics in human medicine, which poses a threat to global public health. Abstract The emergence of antimicrobial resistance (AMR) and multidrug resistance (MDR) among microorganisms to commonly used antibiotics is a growing concern in both human and veterinary medicine. Companion animals play a significant role in the epidemiology of AMR, as their population is continuously increasing, posing a risk of disseminating AMR, particularly to strains of public health importance, such as methicillin-resistant Staphylococcus strains. Thus, this study aimed to investigate the prevalence of AMR and MDR in commensal and infection-causing Staphylococcus spp. in dogs and cats in Valencia region. For this purpose, 271 samples were taken from veterinary centers to assess antimicrobial susceptibility against 20 antibiotics, including some of the most important antibiotics for the treatment of Staphylococcus infections, including the five last resort antibiotics in this list. Of all the samples, 187 Staphylococcus spp. strains were recovered from asymptomatic and skin-diseased dogs and cats, of which S. pseudintermedius (≈60%) was more prevalent in dogs, while S. felis (≈50%) was more prevalent in cats. In the overall analysis of the isolates, AMR was observed for all antibiotics tested, including those crucial in human medicine. Furthermore, over 70% and 30% of the strains in dogs and cats, respectively, exhibited MDR. This study highlights the significance of monitoring the trends in AMR and MDR among companion animals. The potential contribution of these animals to the dissemination of AMR and its resistance genes to humans, other animals, and their shared environment underscores the necessity for adopting a One Health approach.
Increased molecular plasticity along the septotemporal axis of the hippocampus is associated with network functioning

Molecular plasticity crucially supports adaptive cellular and network functioning in the brain. Variations in molecular plasticity may yield important differences in neuronal network dynamics between discrete brain subregions. In the present study we show that the gradual development of sharp waves (SPWs), a spontaneous network activity that is organized under normal in vitro conditions in the CA1 field of ventral but not dorsal hippocampal slices, is associated with region selective molecular reorganization. In particular, increased levels of mRNAs for specific GABAA receptor subunits (α1, β2, γ2) occurred in ventral hippocampal CA1 field during the development of SPWs. These mRNA changes were followed by a clear increase in GABAA receptor number in ventral hippocampus, as shown by [3H]muscimol binding. An increase in mRNAs was also observed in dorsal slices for α2 and α5 subunits, not followed by quantitative GABAA receptor changes. Furthermore, full development of SPWs in the CA1 field (at 3 hours of slice maintenance in vitro) was followed by increased expression of immediate early genes c-fos and zif-268 in ventral hippocampal slices (measured at 5 hours in vitro). No change in c-fos and zif-268 levels is observed in the CA1 field of dorsal slices, which do not develop spontaneous activity. These results suggest that generation of SPWs could trigger specific molecular reorganization in the VH that may be related to the functional roles of SPWs. Correspondingly, the revealed increased potentiality of the ventral hippocampus for molecular reorganization may provide a clue to mechanisms that underlie the regulated emergence of SPWs along the longitudinal axis of the hippocampus. Furthermore, the present evidence suggests that dynamic tuning between spontaneous neuronal activity and molecular organization may importantly contribute to the functional segregation/heterogeneity seen along the hippocampus.
Ranolazine for improving coronary microvascular function in patients with nonobstructive coronary artery disease: a systematic review and meta-analysis with a trial sequential analysis of randomized controlled trials

Background Microvascular dysfunction in patients with nonobstructive coronary artery disease is increasingly being recognized as an important health issue. This systematic review and meta-analysis evaluated the effectiveness of ranolazine, an antianginal agent, in improving coronary microvascular function. Methods We conducted a comprehensive literature search of the Cochrane Library, PubMed, Embase, China National Knowledge Infrastructure, the Chinese BioMedical Literature Database, and gray literature databases until September 30, 2023. The included studies were randomized controlled trials (RCTs) published in the English or Chinese languages that screened for eligibility using two independent investigators. Risk of bias was evaluated with the Cochrane Collaboration tool. Subgroup and sensitivity analyses were used to identify sources of heterogeneity. Meta-analysis was performed using RevMan version 5.4 (Cochrane) and Stata version 16.0 (StataCorp). Results From 1,470 citations, 8 RCTs involving 379 participants were included in this analysis. Our findings showed that ranolazine increased coronary flow reserve (CFR) over an 8 to 12-week follow-up period [standardized mean difference =1.16; 95% confidence interval (CI): 0.4–1.89; P=0.002]. Ranolazine increased the global myocardial perfusion reserve index (MPRI) [weighted mean difference (WMD) =0.18; 95% CI: 0.07–0.29; P=0.002] and the midsubendocardial MPRI (WMD =0.10; 95% CI: 0.02–0.19; P=0.02). Moreover, ranolazine improved 3 of the 5 Seattle Angina Questionnaire scores, namely, physical functioning (WMD =4.89; 95% CI: 0.14 to 9.64; P=0.04), angina stability (WMD =17.31; 95% CI: 7.13–27.49; P=0.0009), and quality of life (WMD =10.11; 95% CI: 3.57–16.65; P=0.0003). Trial sequential analysis showed that the meta-analysis of angina stability and quality of life scores had a sufficient sample size and statistical power. Conclusions Our analysis suggests that ranolazine is associated with improvements in CFR, myocardial perfusion, and the Seattle Angina Questionnaire scores in patients with nonobstructive coronary artery disease. However, further large-scale RCTs with long-term follow-up are recommended to validate these findings and provide a more comprehensive understanding of the effects of ranolazine on coronary microvascular function.
Phytochemical Characterization of Callistemon lanceolatus Leaf Essential Oils and Their Application as Sustainable Stored Grain Protectants against Major Storage Insect Pests

Food storage has been important since the dawn of agriculture and human settlement. Insect pests cause major losses to food grains during storage and production. Essential oils are good alternatives for chemical insecticides for the management of storage pests. Red bottlebrush, Callistemon lanceolatus, is a flowering plant of the Myrtaceae family. This research work aimed to extract the oil from bottlebrush leaves, and chemically characterize and assess their repellent and insecticidal properties against the cowpea seed beetle, Callasobruchus maculatus (F.) (Coleoptera: Chrysomelidae), cigarette beetle, Lasioderma serricorne (F.) (Coleoptera: Ptinidae), and red flour beetle, Tribolium castaneum (Herbst.) (Coleoptera: Tenebrionidae), for the first time. The essential oil yielded by hydro-distillation of bottlebrush leaves was 1.02 ± 0.01%. GC-MS analysis determined the chemical composition of the volatile oil comprised 1,8-cineole (19.17%), α-terpineol (11.51%), α-pinene (10.28%), and α-Phellandrene (9.55%). The C. lanceolatus leaf oil showed potent repellence, contact toxicity, and fumigation toxic effects. In the contact toxicity assay, at 24 h, the LC50 values were 1.35, 0.52, and 0.58 mg/cm2 for the red flour beetle, cigarette beetle, and cowpea seed beetle, respectively. Likewise, in the fumigation assay observed after 24 h, LC50 values of 22.60, 5.48, and 1.43 µL/L air were demonstrated for the red flour beetle, cigarette beetle, and cowpea seed beetle, respectively. Additionally, there was no significance found by a phytotoxicity assay when the paddy seeds were exposed to C. lanceolatus oil. The results show that the volatile oils from red bottlebrush leaves have the potential to be applied as a biopesticide. Therefore, C. lanceolatus leaf oil can be utilized as a bio-insecticide to control stored product insects.
Tracing weathering regimes using the lithium isotope composition of detrital sediments.

Lithium (Li) isotopes are a promising tracer of chemical weathering processes for both modern and ancient times. In order to improve the use of Li isotopes in the sedimentary record, here we calibrate the relationship between weathering intensity and detrital Li isotope composition (δ 7 Li) using the fine fraction of modern large river sediments. Through independent estimates for sediment provenance to calculate the Li isotope signature of the rock from which the sediments derive through weathering, we show that source rock variability (in particular the relative contribution of sedimentary versus igneous rocks) must be corrected for before using Li isotopes as a weathering proxy. We also show that for rivers draining mountain ranges, the contribution to river sediments of particles derived from sedimentary rocks is correlated to their Li/Al ratio, making it possible to use Li contents to estimate the average source rock composition. Once corrected for bedrock variability, the Li isotope signature defines a negative relationship with the weathering intensity (ratio between silicate weathering rate and total denudation rate), with highest Li isotope fractionation for the highest weathering intensity. Altogether, we propose a set of new relationships between weathering, erosion, provenance, and Li isotopes that can be used to quantify present-day and paleo-weathering using detrital sediment.
Factor Analysis of the Application of Patient Safety Target Targets The Risk of Falling in the Emergency Room of the Hospital

Patient safety is a program that aims to reduce the number of unexpected events. Patient safety has become a global issue for hospitals, a top priority to be implemented and is something that is much more important than just service efficiency, it is related to issues of quality and hospital image. Patient safety is a hospital service system that provides safer patient care, to prevent further injuries, namely by setting service standards related to creating an incident reporting system and follow-up. The aim of this research was to determine the relationship between age, education, training, infrastructure and knowledge of nurses on the implementation of patient safety on the risk of falls in the emergency room at Tenriawaru District Hospital. Bone. The research method is a cross sectional approach. In this study the population was nurses in the emergency room at Tenriawaru District Hospital Bone. The sampling technique used total sampling involving all 16 nurses as respondents, using the Chi-Square test. This research was conducted in October 2023