Miracle-dz/UniFAR-FTUs huggingface dataset:
Rhabdomyolysis and statins: A pharmacovigilance comparative study between statins

Rhabdomyolysis is a serious adverse drug reaction of statins. There are few studies comparing the risk of rhabdomyolysis between the different statins. Using the WHO pharmacovigilance database, VigiBase®, we compared the risk of rhabdomyolysis reporting of seven statins (atorvastatin, fluvastatin, lovastatin, pitavastatin, pravastatin, rosuvastatin and simvastatin, with cerivastatin excluded). All reports of rhabdomyolysis in VigiBase® in adults with statins until 31 December 2022 were included. Results are expressed as reporting odds ratio (ROR, 95% CI). Among 10 657 reports with rhabdomyolysis with statins, simvastatin was the highest risk statin in comparison with others: ROR = 2.20 (2.11–2.29). The risk was higher in men, older than 74 years and in cases of drug interactions.
Prevalence of Dry Eye Disease Among Individuals Scheduled for Cataract Surgery in a Norwegian Cataract Clinic

Purpose To determine the prevalence of dry eye disease (DED) in patients scheduled for cataract surgery in a Norwegian eye clinic. Patients and Methods 218 patients scheduled for cataract surgery were examined for DED in one randomly selected eye and questioned regarding symptoms and risk factors. Patients were diagnosed with DED if they fulfilled the DEWS II criteria with symptom score >12/100 with Ocular Surface Disease Index (OSDI) questionnaire, and the presence of any of the three signs: tear osmolarity >307 mOsm/L in either eye or a difference in osmolarity between the two eyes of >8 mOsm/L, corneal fluorescein staining (CSF) ≥ grade 2 and non-invasive tear film breakup time (NIKBUT) of <10 seconds. Additional tests were the Standard Patient Evaluation of Eye Dryness (SPEED) questionnaire, tear meniscus height (TMH), Schirmer 1, tear film thickness (TFT), corneal sensitivity and meibography (meiboscore). Dry eye test outcomes were correlated with risk factors for DED. Results The prevalence of DED was 55.5% according to the DEWS II criteria. The abnormal osmolarity percentage was 66.5, while 29.8% had shortened NIKBUT and 19.7% exhibited CFS ≥2. 57% had Schirmer 1 ≤ 10 mm/5 min, and 81.1% had a meiboscore of ≥1. 71.2% of subjects scored positive for DED symptoms using the OSDI questionnaire and 69.3% using SPEED. Logistic regression analysis showed that higher age correlated with a lower OSDI symptom score, reduced corneal sensitivity and increased meibomian gland atrophy. Female sex was associated with higher odds of having DED, abnormal NIKBUT and abnormal CFS. Ocular tests for DED did not correlate with OSDI symptom scores when assessed with Spearman`s rank analysis. Conclusion The prevalence of DED in an elderly Norwegian population scheduled for cataract surgery is high and associated with female sex. There was a lack of correlation between signs and symptoms of DED.
Investigating the Intrinsic Anisotropy of VO2(101) Thin Films Using Linearly Polarized Resonant Photoemission Spectroscopy

VO2 is one of the most studied vanadium oxides because it undergoes a reversible metal-insulator transition (MIT) upon heating with a critical temperature of around 340 K. One of the most overlooked aspects of VO2 is the band’s anisotropy in the metallic phase when the Fermi level is crossed by two bands: π* and d||. They are oriented perpendicularly in one respect to the other, hence generating anisotropy. One of the parameters tuning MIT properties is the unbalance of the electron population of π* and d|| bands that arise from their different energy position with respect to the Fermi level. In systems with reduced dimensionality, the electron population disproportion is different with respect to the bulk leading to a different anisotropy. Investigating such a system with a band-selective spectroscopic tool is mandatory. In this manuscript, we show the results of the investigation of a single crystalline 8 nm VO2/TiO2(101) film. We report on the effectiveness of linearly polarized resonant photoemission (ResPES) as a band-selective technique probing the intrinsic anisotropy of VO2.
Numerical investigation for entropy‐based magneto nanofluid flow over non‐linear stretching surface with slip and convective boundary conditions

The nanoliquid flows place a significant role in modern research due to the vast number of applications in the Food industry, manufacturing, thermal management, enhanced oil recovery, biomedical applications, and so on. This article presents the analysis of entropy generation on convective nanofluid flow in a three‐dimensional nonlinear stretching sheet with slip effects. Brownian motion and thermophoresis impacts are adopted by the nanoparticle concentration and temperature profiles. The PDEs are remodeled into ODEs by employing the appropriative simulated alternations, and the ODEs are solved by utilizing the R–K–F scheme along with the shooting technique. The main contributions of physical stream factors on the nanofluid concentration, heat, and speed profiles are displayed and explored via plots. Moreover, the rate of heat transfer and surface drag force are examined through tabular structures. In view of this, the nanofluids have more heat transfer capability and improve thermal properties. The slip factors are used in the boundary conditions of the velocity, and the limit conditions are utilized for the hotness and speed of the nanoparticles. The rate of heat transfer in a non‐linear stretching sheet is 1%–2% more than linear stretching sheet for varying values of Prandtl number Pr and Magnetic field M.
Discrete energy conservation in numerical flow simulations with local grid refinement

The behaviour of fluids is studied through the Navier-Stokes equations. Computer models are used to solve these equations in practical situations. However, for many practically interesting applications, computer simulations still take too much time to be useful. To increase the feasibility of simulations in these situations in the future, the speed of computers and the efficiency of the models and calculation methods can be increased. A way to improve the efficiency of the models is tuning the resolution of a calculation grid in such a way that the number of grid points is minimal. Lately, the so-called method of local grid refinement is receiving a lot of attention in this field. It uses jumps in resolution for the transition from coarse to fine grid parts and vice versa. Implementation of fundamental conservation laws is not trivial on grids with local refinement. Typically, solution methods consider only the laws of conservation of mass and momentum and ignore the law of conservation of energy. But since conservation of energy is crucial to obtain stable simulations without artificial diffusion, extension of local grid refinement with this fundamental law is the main theme of this thesis. The research in this thesis shows how energy conservation can be achieved theoretically and demonstrates through simulation results that the proposed method indeed yields stable solutions without artificial diffusion.
A systematic literature review: assessing the impact of sports events between 2010 and 2022

ABSTRACT The literature on the impact of sport events continues to grow. However, existing systematic reviews have often focused on a specific typology of impact and/or specific events. In this article, we highlight the current state of sport events impact literature through a systematic review using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) method. Following predefined criteria, the authors reviewed 172 review and research articles published in indexed journals between 2010 and 2022 that were collected from four databases. Given the limited consensus around the conceptualisation of legacy in the academic literature, it was agreed to limit the keywords for this study to ‘sports’, ‘event’, and ‘impacts’. The term ‘impacts’ seems more precise as it is inclusive in nature, incorporating both ‘legacies’ and intended ‘outcomes’. Results show that five countries, led by the United States, dominate in terms of publications, focusing more on economic impact assessment, particularly of large and single sport events. While studies still focus on mega-events, new research is increasingly turning to small and medium-sized sporting events, and more intangible impacts are attracting the interest of researchers. In particular, studies of consumer behaviour and destination image, as well as planning and evaluation strategies, are gaining momentum, while there is a lack of studies on the health and educational impacts of sports events, as well as the impact of the development of sports infrastructure built around the events.
In Depth Topological Analysis of Arabidopsis Mid-SUN Proteins and Their Interaction with the Membrane-Bound Transcription Factor MaMYB

Mid-SUN proteins are a neglected family of conserved type III membrane proteins of ancient origin with representatives in plants, animals, and fungi. Previous higher plant studies have associated them with functions at the nuclear envelope and the endoplasmic reticulum (ER). In this study, high-resolution confocal light microscopy is used to explore the localisation of SUN3 and SUN4 in the perinuclear region, to explore topology, and to study the role of mid-SUNs on endoplasmic reticulum morphology. The role of SUN3 in the ER is reinforced by the identification of a protein interaction between SUN3 and the ER membrane-bound transcription factor maMYB. The results highlight the importance of mid-SUNs as functional components of the ER and outer nuclear membrane.
Understanding the Tumor Immune Microenvironment in Renal Cell Carcinoma

Simple Summary Over the last decade there has been a significant increase in the number of therapies that activate the host’s immune system to target and eliminate renal cell carcinoma (RCC) tumors. The superior efficacy of these agents demonstrates that host control of RCC requires a robust and effective immune response. Given the increasing incorporation of immune activating agents into routine clinical practice for the management of RCC, it is important for researchers and clinicians to understand the characteristics of the immune microenvironment in RCC tumors. The purpose of this review is to describe the concepts of the anti-tumor immune response to RCC and to provide a detailed summary of the current understanding of the immune response to RCC tumor development and progression. Additionally, this article explores how components of the immune microenvironment are being used to predict response to therapy and patient survival. Abstract Scientific understanding of how the immune microenvironment interacts with renal cell carcinoma (RCC) has substantially increased over the last decade as a result of research investigations and applying immunotherapies, which modulate how the immune system targets and eliminates RCC tumor cells. Clinically, immune checkpoint inhibitor therapy (ICI) has revolutionized the treatment of advanced clear cell RCC because of improved outcomes compared to targeted molecular therapies. From an immunologic perspective, RCC is particularly interesting because tumors are known to be highly inflamed, but the mechanisms underlying the inflammation of the tumor immune microenvironment are atypical and not well described. While technological advances in gene sequencing and cellular imaging have enabled precise characterization of RCC immune cell phenotypes, multiple theories have been suggested regarding the functional significance of immune infiltration in RCC progression. The purpose of this review is to describe the general concepts of the anti-tumor immune response and to provide a detailed summary of the current understanding of the immune response to RCC tumor development and progression. This article describes immune cell phenotypes that have been reported in the RCC microenvironment and discusses the application of RCC immunophenotyping to predict response to ICI therapy and patient survival.
Shear strength of municipal solid waste rejected from material recovery facilities in the city of São Paulo, Brazil

The mechanical behavior of municipal solid waste (MSW) is a critical issue in environmental geotechnics, given the pollution and public health risks associated with slope failures. In Brazil, waste composition is expected to change due to the hierarchy of sustainable practices established by the National Solid Waste Policy, which aims to improve the recovery of organic and recyclable materials. Not much progress has been made since the implementation of this law; thus, its effects on the design and operation of landfills are not fully clear. This study presents and discusses compaction and shear strength parameters of dry MSW after mechanical sorting of medium and large recyclable items and shredding. The maximum dry unit weight for the standard Proctor compaction test ranged from 6.6 to 10.0 kN/m3 and the optimum moisture content ranged from 20% to 42%. Stress-displacement curves of direct shear tests showed strain hardening and shear strength parameters of Mohr-Coulomb envelopes were displacement-dependent. The friction angle ranged from 3.2° to 42.9° and the cohesion intercept ranged from 1.3 to 31.3 kPa, at a displacement of 9 mm (15% of the specimen length). These results are in line with the literature, since a high content of waste materials that proved to affect geotechnical properties, such as plastic, paper, cardboard, textile, and glass, remained after pre-treatment.
The Roles of Trust and Its Antecedent Variables in Healthcare Consumers’ Acceptance of Online Medical Consultation during the COVID-19 Pandemic in China

Online medical consultation (OMC) is generating considerable interest among researchers and practitioners due to the mandatory quarantine measures implemented during the COVID-19 pandemic in China. However, the acceptance rate of OMC has declined over time. This paper aims to empirically investigate OMC acceptance using a proposed research model by integrating the technology acceptance model (TAM) with trust and its antecedent variables. A quantitative self-administered cross-sectional survey was conducted to collect data from 260 healthcare consumers. A partial least squares structural equation modeling method was used to examine the data. Results revealed that healthcare consumers’ behavioral intention was influenced by attitudes, while perceived usefulness and trust significantly influenced behavioral intention through attitude as a mediator. In addition, perceived risk, perceived privacy protection, network externalities, cognitive reputation, and interactivity directly influenced trust. Overall, the research model explained 50% of the variance in attitude and 71% of the variance in behavioral intention. The study’s findings should provide useful insights into making effective design, development, and implementation decisions for OMC services.
Validation of a French version of the Vancouver Obsessional Compulsive Inventory–Mental Contamination scale (VOCI-MC) and the Contamination Thought–Action Fusion scale (CTAF) in non-clinical and clinical samples

Abstract The Vancouver Obsessional Compulsive Inventory–Mental Contamination scale (VOCI-MC) and the Contamination Thought–Action Fusion scale (CTAF) are two self-report instruments that assess symptoms of mental contamination and fusion between thoughts, and feelings and behaviours associated with contamination, respectively. The aim of this study was to investigate the psychometric properties of the French version of these two scales in non-clinical and clinical samples. We included 79 participants diagnosed with obsessive-compulsive disorder (OCD), 31 diagnosed with anxiety disorders, who were recruited from the University Department of Adult Psychiatry in Montpellier, and 320 non-clinical participants recruited from the general population. Psychometric properties of the French VOCI-MC and CTAF were investigated. Results showed that the French versions of the VOCI-MC and the CTAF had high internal consistency, good convergent and divergent validity, as well as good temporal stability. Exploratory and confirmatory factor analyses showed a one-factor structure for the two scales in both non-clinical and OCD samples. Adequate discriminative validity was established by comparing OCD patients with contamination-related symptoms and OCD patients who did not report contamination-related symptoms. The French VOCI-MC and CTAF are valid and appropriate tools for measuring mental contamination in both clinical and research contexts.
Monomial Algebras

Bringing together several areas of pure and applied mathematics, this book shows how monomial algebras are related to polyhedral geometry, combinatorial optimization, and combinatorics of hypergraphs. It directly links the algebraic properties of monomial algebras to combinatorial structures (such as simplicial complexes, posets, digraphs, graphs, and clutters) and linear optimization problems.
Aflatoxin B1 Degradation by Ery4 Laccase: From In Vitro to Contaminated Corn

Aflatoxins (AFs) are toxic secondary metabolites produced by Aspergillus spp. and are found in food and feed as contaminants worldwide. Due to climate change, AFs occurrence is expected to increase also in western Europe. Therefore, to ensure food and feed safety, it is mandatory to develop green technologies for AFs reduction in contaminated matrices. With this regard, enzymatic degradation is an effective and environmentally friendly approach under mild operational conditions and with minor impact on the food and feed matrix. In this work, Ery4 laccase, acetosyringone, ascorbic acid, and dehydroascorbic acid were investigated in vitro, then applied in artificially contaminated corn for AFB1 reduction. AFB1 (0.1 µg/mL) was completely removed in vitro and reduced by 26% in corn. Several degradation products were detected in vitro by UHPLC-HRMS and likely corresponded to AFQ1, epi-AFQ1, AFB1-diol, or AFB1dialehyde, AFB2a, and AFM1. Protein content was not altered by the enzymatic treatment, while slightly higher levels of lipid peroxidation and H2O2 were detected. Although further studies are needed to improve AFB1 reduction and reduce the impact of this treatment in corn, the results of this study are promising and suggest that Ery4 laccase can be effectively applied for the reduction in AFB1 in corn.
Modeling and Simulation of China C Series Large Aircraft with Microburst

To simulate and analyze a large aircraft with severe wind shear, nonlinear equations for a rigid aircraft under various wind conditions were designed. In this paper, a double-vortex-ring method is adopted to generate a three-dimensional microburst wind field. This model incorporates a flight dynamics module and three flight simulations based on various forms of nonlinear equations. In addition, four primary wind gradients are considered to compute the aerodynamic coefficients. In simulation experiments with a China C series large aircraft, equations using air-relative velocities and inertial velocities are compared and analyzed. Although the nonlinear equations derived using the air-relative velocities should be identical to those using the inertial velocities, the results show that the latter are more accurate in practice because the former bring error into the simulation when estimating the acceleration induced by the wind field.
Thermodynamic Response of a Cylindrical Tunnel in the Theory of Generalized Thermoelastic Diffusion

The theory of generalized thermoelastic diffusion of Sherief is used to investigate the dynamic response of infinite elastic medium with a cylindrical tunnel subjected to a time-dependent thermal shock.Without the customary use of potential functions,the direction method of solution,with the help of Laplace technique,is used to solve the coupling thermal,chemical and mechanical governing equation.The analytical solutions of temperature increment,displacement,stress and chemical potential are obtained in the transform domain,and by using the inverse Laplace transform,the numerical results are obtained and used to analyze the distribution of temperature increment,stress,displacement and chemical potential on the condition of thermo-chemo-mechanical coupling.
Synthesis, Properties, and Application of Small-Molecule Hole-Transporting Materials Based on Acetylene-Linked Thiophene Core

Three small molecule organic compounds based on conjugated acetylene-linked methoxy triphenylamine terminal groups with different substituted thiophene cores were synthesized and firstly applied as hole-transporting materials (HTMs). The electron-deficient acetylene linkers can tune the energy levels of frontier molecular orbitals. The physical property measurements show that the HTMs (CJ-05, CJ-06, and CJ-07) possess good stability, hydrophobicity, and film-forming ability. Further, the HTMs were applied in the MAPbI3-based perovskite solar cells (PSCs), and the best power conversion efficiency (PCE) of 6.04%, 6.77%, and 6.48% was achieved, respectively, which implies that they exhibit great potential in photovoltaic applications.
Detection of H275Y oseltamivir resistance gene mutation among Influenza A(H1N1)pdm09 patients by allelic discrimination real‐time RT‐PCR

Influenza viruses can mutate genetically and cause a range of respiratory ailments. The H275Y mutation in the neuraminidase (NA) gene reduces the effectiveness of oseltamivir, a widely used drug for the treatment of Influenza A and B virus infection. The World Health Organization (WHO) recommends single‐nucleotide polymorphism assays to detect this mutation. The present study aims to estimate the prevalence of H275Y mutation conferring oseltamivir resistance in Influenza A(H1N1)pdm09 virus among hospitalized patients from June 2014 to December 2021. Following the WHO protocol, allelic discrimination real‐time RT‐PCR was performed for 752 samples. Out of the 752 samples, 1 tested positive for Y275 gene mutation by allelic discrimination real‐time RT‐PCR. In samples of years 2020 and 2021, neither the H275 nor Y275 genotype was detected. Sequencing of the NA gene of all negative samples showed a mismatch between the NA sequence and the probes used in the allelic discrimination assay. Also, Y275 mutation was detected in only 1 sample from 2020. The prevalence of oseltamivir resistance was estimated as 0.27% among the Influenza A(H1N1)pdm09 patients during 2014−2021. The study highlights that the WHO‐recommended probes for detecting H275Y mutation may not be useful to detect 2020 and 2021 circulating strains of Influenza A(H1N1)pdm09, emphasizing the need for continuous monitoring of mutations in the influenza virus.