Miracle-dz/UniFAR-FTUs huggingface dataset:
P-localization of some classes of groups

The aim for the present paper is to study the theory of P-localization of a group in a category C such that it contains the category of the nilpotent groups as a full sub-category. In the second section we present a number of results on P-localization of a group G, which is the semi-direct product of an abelian group A with a group X, in the category G of all groups. It turns out that the P-localized (GP) is completely described by the P-localized XP of X, A and the action w of X on A. In the third section, we present the construction of the theory of P-localization in the category of all groups which are extensions of nilpotent groups by finite abelian groups. Our proof follows rather closely the one presented in [2, chapter I], and is based on the classical interpretation of the second cohomology group of a group.
Evaluation of Cyclin D1 and Human Epidermal Growth Factor Receptor 2 Neu Protein Expression in Head and Neck Squamous Cell Carcinoma

Background Head and neck cancers are highly aggressive, frequently occurring cancers that are prevalent worldwide. The mainstay of their treatment is surgery, followed by adjuvant therapy. Various studies have documented the usefulness of molecular markers in carcinogenesis and have proven helpful in the diagnosis and treatment of head and neck cancers. Cyclin D1 is a proto‑oncogene, overexpression of which leads to the accelerated entry of cells in the S phase of the cell cycle, causing uncontrolled proliferation of the cells. The dysregulation of human epidermal growth factor receptor 2 (HER2) neu is also related to multiple features of malignancy, including loss of cell cycle control, induction of angiogenesis, and resistance to apoptotic stimuli. This study seeks to identify a subset of patients with a bad prognosis who may require aggressive treatment strategies. Aim This study aims to determine the proportion of the expression of cyclin D1 and HER2 neu in head and neck squamous cell carcinoma (HNSCC) and analyze the association between the expression of cyclin D1 and HER2 neu using histological grading, tumor, node, and metastasis (TNM) staging, and nodal status of the tumor. Furthermore, this study also aims to document clinical outcomes, such as locoregional control, depth of invasion (DOI), and regional metastasis regarding the expression of cyclin D1 and HER2 neu in HNSCC. Setting and design This study is a laboratory-based observational study. Materials and methods Seventy histologically proven cases of HNSCC were studied for various histopathological parameters, and further immunohistochemistry (IHC) was performed for cyclin D1 and HER2 neu. The expression and intensity of cyclin D1 were multiplied, and the total score was derived. The College of American Pathologists/American Society of Clinical Oncology (CAP/ASCO) guidelines for HER2 neu testing in breast cancer were used for scoring. Result Out of 70 cases, 52 (75%) demonstrated strong and moderate positivity for cyclin D1, and the p-values were 0.017, 0.001, and 0.032 for depth of invasion, TNM stage, and lymph node metastases, respectively, for cyclin D1, which was considered statistically significant. For HER2 neu, five out of 70 cases were positive, and the p-value was significant for depth of invasion (0.008). Conclusion The expression of the above marker cyclin D1 increases with stage, DOI, and positive lymph node status. Hence, cyclin D1 immunoexpression can be helpful in the early assessment of HNSCC behavior and can serve as an independent prognostic marker. Furthermore, it was observed that HER2 neu was significant with an increase in depth of invasion of tumor, which, in the American Joint Committee on Cancer (AJCC) eighth edition, is considered an important factor for determining the stage of the tumor. Further research is needed to examine whether HER2 neu can act as a prognostic factor for HNSCC and if it can be targeted for treatment options.
Description of the Three Complete Mitochondrial Genomes of Sitta (S. himalayensis, S. nagaensis, and S. yunnanensis) and Phylogenetic Relationship (Aves: Sittidae)

Nuthatches (genus Sitta; family Sittidae) are a passerine genus with a predominantly Nearctic and Eurasian distribution. To understand the phylogenetic position of Sitta and phylogenetic relations within this genus, we sequenced the complete mitochondrial genomes of three Sitta species (S. himalayensis, S. nagaensis, and S. yunnanensis), which were 16,822–16,830 bp in length and consisted of 37 genes and a control region. This study recovered the same gene arrangement found in the mitogenomes of Gallus gallus, which is considered the typical ancestral avian gene order. All tRNAs were predicted to form the typical cloverleaf secondary structures. Bayesian inference and maximum likelihood phylogenetic analyses of sequences of 18 species obtained a well-supported topology. The family Sittidae is the sister group of Troglodytidae, and the genus Sitta can be divided into three major clades. We demonstrated the phylogenetic relationships within the genus Sitta (S. carolinensis + ((S. villosa + S. yunnanensis) + (S. himalayensis + (S. europaea + S. nagaensis)))).
Probiotic-Fermented Camel Milk Attenuates Neurodegenerative Symptoms via SOX5/miR-218 Axis Orchestration in Mouse Models

Multiple sclerosis is an autoimmune-mediated myelin damage disorder in the central nervous system that is widespread among neurological patients. It has been demonstrated that several genetic and epigenetic factors control autoimmune encephalomyelitis (EAE), a murine model of MS, through CD4+ T-cell population quantity. Alterations in the gut microbiota influence neuroprotectiveness via unexplored mechanisms. In this study, the ameliorative effect of Bacillus amyloliquefaciens fermented in camel milk (BEY) on an autoimmune-mediated neurodegenerative model using myelin oligodendrocyte glycoprotein/complete fraud adjuvant/pertussis toxin (MCP)-immunized C57BL6j mice is investigated. Anti-inflammatory activity was confirmed in the in vitro cell model, and inflammatory cytokines interleukins IL17 (from EAE 311 to BEY 227 pg/mL), IL6 (from EAE 103 to BEY 65 pg/mL), IFNγ (from EAE 423 to BEY 243 pg/mL) and TGFβ (from EAE 74 to BEY 133 pg/mL) were significantly reduced in BEY-treated mice. The epigenetic factor miR-218-5P was identified and confirmed its mRNA target SOX-5 using in silico tools and expression techniques, suggesting SOX5/miR-218-5p could serve as an exclusive diagnostic marker for MS. Furthermore, BEY improved the short-chain fatty acids, in particular butyrate (from 0.57 to 0.85 µM) and caproic (from 0.64 to 1.33 µM) acids, in the MCP mouse group. BEY treatment significantly regulated the expression of inflammatory transcripts in EAE mice and upregulated neuroprotective markers such as neurexin (from 0.65- to 1.22-fold) (p < 0.05), vascular endothelial adhesion molecules (from 0.41- to 0.76-fold) and myelin-binding protein (from 0.46- to 0.89-fold) (p < 0.03). These findings suggest that BEY could be a promising clinical approach for the curative treatment of neurodegenerative diseases and could promote the use of probiotic food as medicine.
Career sailboat: a model for enhancing career decision-making self-efficacy among job-seekers

ABSTRACT We examined the effects of a five-week psychoeducational programme based on the Career Sailboat model on career decision-making self-efficacy levels of Turkish university students in their job-seeking phase. Twenty-six university students were assigned to one of three groups: experimental group (EG) (n = 9), the placebo group (PG) (n = 7) and the control group (CG) (n = 10). The EG post-test scores were higher than that of the CG but not higher than that of the PG. Pre-test vs. post-test paired comparisons indicated a significant increase in career decision-making self-efficacy level only for the EG group. The use of a quantitative paradigm, specifically an experimental design, was supplemented by soliciting qualitative data as well. The findings based on the qualitative data support the quantitative findings.
Affine parameter-dependent Lyapunov functions and real parametric uncertainty

This paper presents new tests to analyze the robust stability and/or performance of linear systems with uncertain real parameters. These tests are extensions of the notions of quadratic stability and performance where the fixed quadratic Lyapunov function is replaced by a Lyapunov function with affine dependence on the uncertain parameters. Admittedly with some conservatism, the construction of such parameter-dependent Lyapunov functions can be reduced to a linear matrix inequality (LMI) problem and hence is numerically tractable. These LMI-based tests are applicable to constant or time-varying uncertain parameters and are less conservative than quadratic stability in the case of slow parametric variations. They also avoid the frequency sweep needed in real-/spl mu/ analysis, and numerical experiments indicate that they often compare favorably with /spl mu/ analysis for time-invariant parameter uncertainty.
A 220-294 GHz Power Amplifier with 10-dBm Psat and 2.2% PAE in 250-nm InP DHBT

We designed and fabricated a 300-GHz-band power amplifier (PA) with a wide bandwidth, high output power, and high power-added efficiency (PAE) in in-house 250-nm indium phosphide (InP) double heterojunction bipolar transistor (DHBT) technology having an fmax of 480 GHz. To obtain high PAE, we investigated an optimization method for designing the PA at an optimum point in the trade-off between the output power and DC power consumption (PDC). We proposed a low-loss T-junction power combiner with impedance convertors to maximize the output power and the PAE. Furthermore, we used dense through substrate vias (TSVs) to stabilize the ground and to suppress the oscillation to ensure a high gain and high PAE. The fabricated PA achieved a -3 dB bandwidth of 74 GHz from 220 GHz to 294 GHz, saturation power (Psat) of 10.6 dBm, and PAE of 2.24%.
Parameter identification with weightless regularization

Although the regularization increased the popularity of parameter identification due to its capability of deriving a stable solution, the significant problem is that the solution depends upon the regularization parameters chosen. This paper presents a technique for deriving solutions without the use of the parameters and, further, an optimization method, which can work efficiently for problems of concern. Numerical examples show that the technique can efficiently search for appropriate solutions. Copyright © 2001 John Wiley & Sons, Ltd.
Progranulin Deficiency Induces Mitochondrial Dysfunction in Frontotemporal Lobar Degeneration with TDP-43 Inclusions

Loss-of-function (LOF) mutations in GRN gene, which encodes progranulin (PGRN), cause frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP). FTLD-TDP is one of the most common forms of early onset dementia, but its pathogenesis is not fully understood. Mitochondrial dysfunction has been associated with several neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD) and amyotrophic lateral sclerosis (ALS). Here, we have investigated whether mitochondrial alterations could also contribute to the pathogenesis of PGRN deficiency-associated FTLD-TDP. Our results showed that PGRN deficiency induced mitochondrial depolarization, increased ROS production and lowered ATP levels in GRN KD SH-SY5Y neuroblastoma cells. Interestingly, lymphoblasts from FTLD-TDP patients carrying a LOF mutation in the GRN gene (c.709-1G > A) also demonstrated mitochondrial depolarization and lower ATP levels. Such mitochondrial damage increased mitochondrial fission to remove dysfunctional mitochondria by mitophagy. Interestingly, PGRN-deficient cells showed elevated mitochondrial mass together with autophagy dysfunction, implying that PGRN deficiency induced the accumulation of damaged mitochondria by blocking its degradation in the lysosomes. Importantly, the treatment with two brain-penetrant CK-1δ inhibitors (IGS-2.7 and IGS-3.27), known for preventing the phosphorylation and cytosolic accumulation of TDP-43, rescued mitochondrial function in PGRN-deficient cells. Taken together, these results suggest that mitochondrial function is impaired in FTLD-TDP associated with LOF GRN mutations and that the TDP-43 pathology linked to PGRN deficiency might be a key mechanism contributing to such mitochondrial dysfunction. Furthermore, our results point to the use of drugs targeting TDP-43 pathology as a promising therapeutic strategy for restoring mitochondrial function in FTLD-TDP and other TDP-43-related diseases.
The core content framework and the ‘new science’ of educational research

ABSTRACT This paper unpacks the assumptions underpinning England’s new Core Content Framework (CCF) in respect of the educational research required for teacher expertise, with particular attention to the sources referenced in the final part of the CCF and claims that these constitute the ‘best available educational research’. Drawing on sociological studies of educational knowledge, and assessments of the quality of educational research in England, in addition to the philosophy of expertise as related to teaching, it is argued that the CCF is currently orientated towards a scientism that (i) marginalises longstanding traditions of educational thought, and (ii) technicises and instrumentalises teaching practice. The predominance of a scientistic model of educational knowledge is demonstrated through a profile of the sources identified in the CCF, with a focus on the journals in which referenced material is published and an overview of subject matter via an analysis of keywords and titles. With an overwhelming preference for this ‘New Science’ as opposed to other traditions of educational knowledge, the CCF encourages an image of teaching as a decontextualised series of interventions with narrow objectives, and thus implicitly marginalises wider educational goods and purposes and deprofessionalises teachers work.
A fast algorithm for half-cyclic convolution

The definition of half-cyclic convolution is introduced. It is shown that the computation for cyclic convolution can be carried out based on the half-cyclic convolution, which is more general. The algorithm for half-cyclic convolution then can be used to build an algorithm for cyclic convolution and the fast Fourier transform (FFT), so that some problems in the algorithms for cyclic convolution and the FFT can be solved. An efficient and well-structured algorithm for half-cyclic convolution has been designed, called the Winograd-like algorithm. <<ETX>>
Behcet’s disease in a patient with primary sclerosing cholangitis: a case report and literature review

Behçet’s disease (BD) is a rare, chronic multisystem disease of unknown aetiology. Clinically, it presents with ulceration located on the oral and genital mucosa, skin, uveitis, arthritis and neurological disorders. Most commonly, the disease affects men in the second and third decades of life and occurs endemically. The vast majority of cases have been reported in Asia and the Mediterranean area. The diagnosis of this disease is difficult, especially because of its rare occurrence in Central Europe. In this report, we present the case of BD in a 56-year-old man with primary sclerosing cholangitis, followed by a literature review covering current insights into BD aetiology, diagnostics and treatment.
Entropy and Cross-Level Orderliness in Light of the Interconnection between the Neural System and Consciousness

Despite recent advances, the origin and utility of consciousness remains under debate. Using an evolutionary perspective on the origin of consciousness, this review elaborates on the promising theoretical background suggested in the temporospatial theory of consciousness, which outlines world-brain alignment as a critical predisposition for controlling behavior and adaptation. Such a system can be evolutionarily effective only if it can provide instant cohesion between the subsystems, which is possible only if it performs an intrinsic activity modified in light of the incoming stimulation. One can assume that the world-brain interaction results in a particular interference pattern predetermined by connectome complexity. This is what organisms experience as their exclusive subjective state, allowing the anticipation of regularities in the environment. Thus, an anticipative system can emerge only in a regular environment, which guides natural selection by reinforcing corresponding reactions and decreasing the system entropy. Subsequent evolution requires complicated, layered structures and can be traced from simple organisms to human consciousness and society. This allows us to consider the mode of entropy as a subject of natural evolution rather than an individual entity.
Diagnosis of Dengue Virus Infections Imported to Hungary and Phylogenetic Analysis of Virus Isolates

Background: Dengue virus is one of the most important arbovirus infections of public health concern. Between 2017 and June 2022, 75 imported dengue infections were confirmed by laboratory diagnostic methods in Hungary. Our study aimed to isolate the imported Dengue strains and characterize them by whole-genome sequencing. Methods: Laboratory diagnosis of imported infections was carried out using both serological and molecular methods. Virus isolation was attempted on Vero E6 cell lines. An in-house amplicon-based whole-genome sequencing method was applied for the detailed molecular characterization of the isolated virus strains. Results: From 75 confirmed Dengue infected patients, 68 samples were used for virus isolation. Isolation and whole-genome sequencing were successful in the case of eleven specimens. Isolated strains belonged to Dengue-1,-2,-3 serotypes. Discussion: The isolated strains corresponded to the circulating genotypes of the visited geographic area, and some of the genotypes were linked with more severe DENV cases in the literature. We found that multiple factors, including viral load, specimen type, and patient antibody status, influence the isolation efficacy. Conclusions: Analysis of imported DENV strains can help estimate the outcomes of a possible local DENV transmission in Hungary, a threat from the near future.
Nonlinear ekman suction and ageostrophic effects in rapidly rotating flows

Abstract A model is formulated to study the underlying dynamics of observed asymmetries in laboratory experiments on sidewall boundary layer separation and vertical shear layer instability in rapidly rotating fluids. These experiments show differences in transition behavior depending on the nature, cyclonic or anticyclonic, of the gyre forcing. Such qualitative signatures cannot be explained by the standard f-plane quasi-geostrophic model that is unaffected, apart from a switching of the flow direction, under changes of the sign of the forcing. An important ingredient of the intermediate model derived here is a nonlinear Ekman suction condition, which includes products of the interior velocity and its derivatives. The potential vorticity equation is closed using this nonlinear suction condition and other ageostrophic advections. For the case of a cylindrical, f-plane, barotropic ocean bounded by a vertical wall at r = L, and with a weak bottom slope, the nonlinear Ekman layers inhibit sidewall boundary la.
NORTH AMERICAN REGIONAL REANALYSIS

In 1997, during the late stages of production of NCEP–NCAR Global Reanalysis (GR), exploration of a regional reanalysis project was suggested by the GR project's Advisory Committee, “particularly if the RDAS [Regional Data Assimilation System] is significantly better than the global reanalysis at capturing the regional hydrological cycle, the diurnal cycle and other important features of weather and climate variability. ” Following a 6-yr development and production effort, NCEP's North American Regional Reanalysis (NARR) project was completed in 2004, and data are now available to the scientific community. Along with the use of the NCEP Eta model and its Data Assimilation System (at 32-km–45-layer resolution with 3-hourly output), the hallmarks of the NARR are the incorporation of hourly assimilation of precipitation, which leverages a comprehensive precipitation analysis effort, the use of a recent version of the Noah land surface model, and the use of numerous other datasets that are additional or improv.
Accuracy of Resting Metabolic Rate Prediction Equations in Sport Climbers

Resting metabolic rate (RMR) represents the energy required to maintain vital body functions. In dietary practice, RMR is determined by predictive equations on the basis of using body weight or fat-free mass. Our study aimed to assess whether predictive equations used to estimate RMR are reliable tools for estimating the energy requirements of sport climbers. The study included 114 sport climbers whose RMR was measured with a Fitmate WM. Anthropometric measurements were performed with X-CONTACT 356. The resting metabolic rate was measured by indirect calorimetry and was compared with the RMR estimated by 14 predictive equations on the basis of using body weight/fat-free mass. All equations underestimated RMR in male and female climbers, except for De Lorenzo’s equation in the group of women. The De Lorenzo equation demonstrated the highest correlation with RMR in both groups. The results of the Bland–Altman tests revealed an increasing measurement error with increasing metabolism for most of the predictive equations in male and female climbers. All equations had low measurement reliability according to the intraclass correlation coefficient. Compared with the indirect calorimetry measurement results, none of the studied predictive equations demonstrated high reliability. There is a need to develop a highly reliable predictive equation to estimate RMR in sport climbers.
Test of the NbAl insert and ITER central solenoid model coil

The Central Solenoid Model Coil (CSMC) was designed and built by an ITER collaboration in 1993-2001. Three heavily instrumented Inserts have been also built for testing in the background field of the CSMC. The Nb/sub 3/Al Insert was designed and built by Japan to explore the feasibility of an alternative to Nb/sub 3/Sn superconductor for fusion magnets. The Nb/sub 3/Al Insert coil was tested in the CSMC Test Facility at the Japan Atomic Energy Research Institute, Naka, Japan in March-May 2002. It was the third Insert tested in this facility under this program. The Nb/sub 3/Al Insert coil was charged successfully without training in the background field of the CSMC to the design current of 46 kA at 13 T peak field and later was successfully charged up to 60 kA in 12.5 T field. This paper presents the test results overview.