Miracle-dz/UniFAR-FTUs huggingface dataset:
Sex differences in acute cannabis effects revisited: Results from two randomized, controlled trials

Some evidence suggests that males and females may differ in their responses to acute cannabis effects, including subjective drug effects and behavioural effects, and cannabinoid pharmacokinetics. This is significant given current changes to cannabis‐related policies and, in consequence, increased cannabis accessibility. The present study combines data from two randomized controlled trials to investigate possible differences among males (n = 21) and females (n = 19) in the acute effects of vaporized cannabis containing 13.75 mg Δ9‐tetrahydrocannabinol (THC), with and without cannabidiol (CBD; 13.75 mg). To control for differences in the timing of assessments, peak (or peak change from baseline) scores were calculated for a range of measures including subjective drug effects, cognitive performance, cardiovascular effects, and plasma concentrations of THC, CBD, and their respective primary metabolites. While THC elicited robust and significant changes in all but one outcome measure relative to placebo, relatively few sex differences were observed after controlling for BMI and plasma THC concentrations. Relative to females, males performed better overall on a divided attention task (DAT) and had higher peak plasma concentrations of 11‐nor‐9‐carboxy‐THC (11‐COOH‐THC). Males and females did not differ with respect to plasma concentrations of any other analyte, subjective drug effects, or cardiovascular measures. These data indicate an absence of systematic sex differences in acute cannabis effects given a moderate dose of vaporized cannabis. They do not preclude the possibility that sex differences may emerge with higher THC doses or with other commonly used routes of administration (e.g., orally administered oils or edibles).
REL-1017 (Esmethadone) as Adjunctive Treatment in Patients With Major Depressive Disorder: A Phase 2a Randomized Double-Blind Trial.

OBJECTIVE The purpose of this study was to examine the effects of REL-1017 (esmethadone), a novel N-methyl-d-aspartate receptor (NMDAR) channel blocker, in patients with major depressive disorder who failed to benefit from one to three standard antidepressant treatments in their current major depressive episode. METHODS A 7-day phase 2 multicenter randomized double-blind placebo-controlled trial, comprising three arms, was conducted to assess the safety, tolerability, pharmacokinetics, and efficacy of two dosages of REL-1017 (25 mg or 50 mg orally once a day). Patients were randomly assigned in a 1:1:1 ratio to placebo (N=22), REL-1017 25 mg/day (N=19), or REL-1017 50 mg/day (N=21). Safety scales included the 4-item Positive Symptom Rating Scale for psychotomimetic symptoms, the Clinician-Administered Dissociative States Scale for dissociative symptoms, the Clinical Opiate Withdrawal Scale for withdrawal signs and symptoms, and the Columbia-Suicide Severity Rating Scale for suicidality. The primary efficacy endpoint was the Montgomery-Åsberg Depression Scale (MADRS) score. All 62 randomly assigned patients were included in the full analysis set population analysis. RESULTS Patients experienced mild or moderate transient adverse events and no evidence of dissociative or psychotomimetic effects, opioid effects, or withdrawal signs and symptoms. The improvement in MADRS score shown on day 4 in both of the REL-1017 dosage groups was sustained through day 7 (last dose) and day 14 (7 days after the last dose), with effect sizes from 0.7 to 1.0. CONCLUSIONS This trial showed favorable safety, tolerability, and pharmacokinetic profiles and suggests that REL-1017 may have rapid and sustained antidepressant effects compared with placebo in patients with inadequate responses to antidepressant treatments. These results will need confirmation in larger and longer trials.
Structure of Green Supply Chain Management for Sustainability of Small and Medium Enterprises

Today’s manufacturing-based small and medium enterprises (SME) face the need to implement green supply chains more efficiently in order to overcome environmental barriers in increasingly competitive markets and to improve financial performance. This study examines the structural relationship between environmental collaboration, green innovation capacity, and performance based on the findings of previous studies in order to identify the factors affecting the green supply chain management (GSCM) performance of Korean manufacturing-based SMEs. The study finds that environmental collaboration in the green supply chain environment is an important driver of green innovation capacity for manufacturing-based Korean SMEs. It also finds that green innovation capacity has a positive effect on financial performance through environmental performance. This study establishes a theoretical basis for the systematic study of the structural mechanisms of green supply chains and suggests strategic directions for manufacturing-based SMEs’ successful GSCM implementation.
Regular Aerobic Exercise Attenuates Pain and Anxiety in Mice by Restoring Serotonin-Modulated Synaptic Plasticity in the Anterior Cingulate Cortex

ABSTRACT Purpose Clinical studies found that regular aerobic exercise has analgesic and antianxiety effects; however, the underlying neural mechanisms remain unclear. Multiple studies have suggested that regular aerobic exercise may exert brain-protective effects by promoting the release of serotonin, which may be a pain modulator. Anterior cingulate cortex (ACC) is a key brain area for pain information processing, receiving dense serotonergic innervation. As a result, we hypothesized that exercise may increase the release of serotonin in the ACC, thus improving pain and anxiety behaviors. Methods Integrative methods were used, including behavioral, electrophysiological, pharmacological, biochemical, and genetic approaches, to explore the effects of regular aerobic exercise and the underlying neural mechanisms. Results Regular aerobic exercise in the form of voluntary wheel running for 30 min daily for 15 d showed significant effectiveness in relieving pain and concomitant anxiety in complete Freund’s adjuvant–induced chronic inflammation pain models. c-Fos staining and multielectrode array recordings revealed alterations in neuronal activities and synaptic plasticity in the ACC. Moreover, systemic pharmacological treatment with 4-chloro-dl-phenylalanine (PCPA) to deplete endogenous serotonin and local delivery of serotonin to the ACC revealed that exercise-related serotonin release in the ACC bidirectionally modulates pain sensitization and anxiety behaviors by modulating synaptic plasticity in the ACC. Furthermore, we found that 5-HT1A and 5-HT7 receptors mediated the serotonin modulation effects under conditions of regular aerobic exercise through local infusion of a selective antagonist and shRNA in the ACC. Conclusions Our results reveal that regular aerobic exercise can increase serotonin release and modulate synaptic plasticity in the ACC, ultimately improving pain and concomitant anxiety behaviors through the functions of the 5-HT1A and 5-HT7 receptors.
Writing Center Visitors: Influence of L1 Writing Skills on Students’ Exophonic Writings

This study investigated the influence of acquired L1 writing skills on exophonic writings of students (N = 147) from diverse majors, who visited an English writing center for assistance. Affective differences revealed students with L1 writing tutelage (WL1) had lower avoidance behavior and higher extrinsic motivation and writing self-efficacy. Self-perceived L2 writing ability was found to be a principal factor for WL1. Writing self-efficacy appeared essential for students without L1 writing tutelage (WOL1). Regression analysis found learner self-beliefs and somatic anxiety (negative) influenced self-perceived L2 writing ability for WL1, and holistic self-beliefs on English writing (HSE) and cognitive ability (negative) for WOL1. Acquired L1 writing skills did not tangibly influence L2 performance. No large impact factors were found for WL1, but HSE and attitudes & reaction (negative) impacted WOL1 performance. Implications such as performance may not be a main concern among exophonic writers, and the need for English writing centers in non-L1 (English) countries are discussed.
Coupled Effect of Elevated Temperature and Cooling Conditions on the Properties of Ground Clay Brick Mortars

Abstract When a concrete structure is exposed to fire and cooling, some deterioration in its chemical resistivity and mechanical properties takes place. This deterioration can reach a level at which the structure may have to be thoroughly renovated or completely replaced. In this investigation, four types of cement mortars, ground clay bricks (GCB)/sand namely 0/3, 1/2, 2/1 and 3/0, were used. Three different cement contents were used: 350, 400 and 450 kg/m3. All the mortars were prepared and cured in tap water for 3 months and then kept in laboratory atmospheric conditions up to 6 months. The specimens were subjected to elevated temperatures up to 700°C for 3h and then cooled by three different conditions: water, furnace, and air cooling. The results show that all the mortars subjected to fire, irrespective of cooling mode, suffered a significant reduction in compressive strength. However, the mortars cooled in air exhibited a relativity higher reduction in compressive strength rather than those water or furnace cooled. The mortars containing GCB/sand (3/0) and GCB/sand (1/2) exhibited a relatively higher thermal stability than the others.
Adapted Protocol for Saccharibacteria Cocultivation: Two New Members Join the Club of Candidate Phyla Radiation

In this study, the first TaqMan real-time quantitative PCR (qPCR) system has been developed. This technique can specifically quantify Saccharibacteria members in any sample of interest in order to investigate their prevalence. ABSTRACT The growing application of metagenomics to different ecological and microbiome niches in recent years has enhanced our knowledge of global microbial biodiversity. Among these abundant and widespread microbes, the candidate phyla radiation (CPR) group has been recognized as representing a large proportion of the microbial kingdom (>26%). CPR are characterized by their obligate symbiotic or exoparasitic activity with other microbial hosts, mainly bacteria. Currently, isolating CPR is still considered challenging for microbiologists. The idea of this study was to develop an adapted protocol for the coculture of CPR with a suitable bacterial host. Based on various sputum samples, we tried to enrich CPR (Saccharibacteria members) and to cocultivate them with pure hosts (Schaalia odontolytica). This protocol was monitored by TaqMan real-time quantitative PCR (qPCR) using a system specific for Saccharibacteria designed in this study, as well as by electron microscopy and sequencing. We succeeded in coculturing and sequencing the complete genomes of two new Saccharibacteria species, “Candidatus Minimicrobia naudis” and “Candidatus Minimicrobia vallesae. ” In addition, we noticed a decrease in the CT values of Saccharibacteria and a significant multiplication through their physical association with Schaalia odontolytica strains in the enriched medium that we developed. This work may help bridge gaps in the genomic database by providing new CPR members, and in the future, their currently unknown characteristics may be revealed. IMPORTANCE In this study, the first TaqMan real-time quantitative PCR (qPCR) system, targeting Saccharibacteria phylum, has been developed. This technique can specifically quantify Saccharibacteria members in any sample of interest in order to investigate their prevalence. In addition, another easy, specific, and sensitive protocol has been developed to maintain the viability of Saccharibacteria cells in an enriched medium with their bacterial host. The use of this protocol facilitates subsequent studies of the phenotypic characteristics of CPR and their physical interactions with bacterial species, as well as the sequencing of new genomes to improve the current database.
In-Situ Monitoring of Photoresist Thickness Contour

In microelectronics processing, coating of photoresist is a common process. It is important to ensure the uniformity of the photoresist thickness across the wafer. In this paper, we propose an in-situ monitoring system. In the setup, a spectrometer is used to measure the photoresist thickness contour on the wafer after the spin-coat step or edge-bead removal step. The experimental results are compared with off-line ellipsometer measurements. The worst-case error is experimentally found to be less than 2%.
How Can Buddhist Education Help Adolescents Develop Moral Behavior?

Abstract Although Buddhist education has been widely used all over the world, Vietnamese students cannot currently access it at school. Recently, some Truc Lam (Bamboo Forest) Zen monasteries have offered religious education to adolescents in the hope of improving their moral behavior. However, no empirical studies have evaluated the effectiveness of these efforts. As a result, this study examined whether Buddhism helps teenagers develop moral behaviors. The findings showed that Buddhist religious education can enhance adolescents’ understanding of Buddhist doctrines, increase their faith, and promote Buddhist practices. As a result, they committed antisocial behaviors less often.
The influence of obesity on biological agents treatment response in psoriatic arthritis: HUR-BIO real life results

107 Atıf / Cite this article as: Farisoğulları B, Yardımcı GK, Sarı A, Armağan B, Bilgin E, Bölek EÇ, Duran E, Ayan G, Özsoy Z, Sandal Uzun G, Kılıç L, Akdoğan A, Karadağ Ö, Apraş Bilgen Ş, Ertenli Aİ, Kiraz S, Kalyoncu U. The influence of obesity on biological agents treatment response in psoriatic arthritis: HUR-BIO real life results. Ulus Romatol Derg 2021;13(3):107-115 İletişim / Cor res pon den ce: Bayram Farisoğulları MD, Hacettepe University Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Ankara, Turkey Tel. : +90 506 504 20 17 E-posta: bayramfarisogullari@gmail.com ORCID ID: orcid.org/0000-0002-9394-1103 Ge liş Ta ri hi/Re cei ved: 05.08. 2021 Ka bul Ta ri hi/Ac cep ted: 18.10. 2021 Öz
Treponema pallidum genome sequencing from six continents reveals variability in vaccine candidate genes and dominance of Nichols clade strains in Madagascar

In spite of its immutable susceptibility to penicillin, Treponema pallidum (T. pallidum) subsp. pallidum continues to cause millions of cases of syphilis each year worldwide, resulting in significant morbidity and mortality and underscoring the urgency of developing an effective vaccine to curtail the spread of the infection. Several technical challenges, including absence of an in vitro culture system until very recently, have hampered efforts to catalog the diversity of strains collected worldwide. Here, we provide near-complete genomes from 196 T. pallidum strains–including 191 T. pallidum subsp. pallidum–sequenced directly from patient samples collected from 8 countries and 6 continents. Maximum likelihood phylogeny revealed that samples from most sites were predominantly SS14 clade. However, 99% (84/85) of the samples from Madagascar formed two of the five distinct Nichols subclades. Although recombination was uncommon in the evolution of modern circulating strains, we found multiple putative recombination events between T. pallidum subsp. pallidum and subsp. endemicum, shaping the genomes of several subclades. Temporal analysis dated the most recent common ancestor of Nichols and SS14 clades to 1717 (95% HPD: 1543–1869), in agreement with other recent studies. Rates of SNP accumulation varied significantly among subclades, particularly among different Nichols subclades, and was associated in the Nichols A subclade with a C394F substitution in TP0380, a ERCC3-like DNA repair helicase. Our data highlight the role played by variation in genes encoding putative surface-exposed outer membrane proteins in defining separate lineages, and provide a critical resource for the design of broadly protective syphilis vaccines targeting surface antigens.
"Oral Manifestations of Behcet’s Syndrome: Case Report"

Behcet’s syndrome is an autoimmune disease of the seronegative vasculitic type, with a disease of vessels of variable caliber. It is mainly characterized by oral ulcers, genital ulcers and uveitis. The purpose of this case is to describe the oral manifestations and therapeutic behavior to be followed before a patient with Behcet syndrome. For our purpose, the case of a 20-year-old patient, female, black race, urban origin, who goes to the emergency departments of Maxillofacial Surgery of the body of guard of the Provincial Hospital Dr. Gustavo Aldereguía Lima in the province of Cienfuegos, referred by the specialist in Comprehensive General Stomatology who provided services in the area of health corresponding to the patient for presenting multiple ulcerated lesions throughout the oral cavity and lips. It was concluded that oral ulcers in Behcet’s disease are the first clinical manifestation, which in most cases, lead the patient to seek medical help and are considered by countless authors as the cornerstone to reach the diagnosis of this disease. A total of 14 bibliographies were consulted.
Exploring Online Teachers’ Pedagogical Content Knowledge in Business English Teaching: A Hermeneutic Study

This study explored the online Business English teachers’ pedagogical content knowledge (PCK) to understand its essence in Business English teaching. It sought to uncover what they thought about PCK in Business English lessons and how they developed their PCK as they engaged themselves in the everyday teaching of Business English. Hermeneutic phenomenology was employed since the purpose of the study concerns the reflection and interpretation of the online Business English teachers' experiences. The participants of the study were six online Business English teachers from one ESL Company in the Philippines catering to business professionals. They were chosen through homogeneous purposive sampling. The data collection included in-depth interviewing following semi-structured interviews and observations to gather rich descriptions of the participants' reflection and interpretation of their experiences. The data were analyzed using the six-step data analysis of Smith et al. (2021) due to the interpretive nature of the study. The results of the analysis revealed that the online Business English teachers thought of PCK as knowledge of strategizing, knowledge of Business English as the language in the workplace, and knowledge of Business English being distinct from General English. Additionally, the findings reported that teachers developed their PCK through several sources such as their encounter in the field, growth processes, and perceived need for further PCK development in Business English teaching. A creative synthesis captures the essential themes. Despite the online Business English teachers’ patent consciousness of their PCK in Business English, they still demonstrated the need to be exposed more to the business field and broaden their knowledge of business phrases and expressions. Teacher interaction with various types of students, and feedback from senior colleagues helped develop and widen their PCK in Business English.
Unraveling the adaptive significance of mitochondrial genome variability of Drosophila obscura

: Drosophila obscura is a very common fruit fly inhabiting European forests. This species has a large number of mitochondrial haplotypes of Cyt b gene. We used experimental lines of D. obscura to test the adaptive significance of intra-population variability of the mitochondrial genome (mtDNA) and selective forces that maintain it. We chose three isofemale lines with distinct mitochondrial haplotypes of Cyt b gene from each of the two populations sampled in Serbia. Using back-crossing, we created nine experimental lines for each population with all combinations of mtDNA haplotypes and nuclear genetic backgrounds (nuDNA). Individuals of both sexes were tested separately for desiccation resistance at two temperatures. Cox proportional hazards model, with four factors: mtDNA, nuDNA, sex and temperature was used to analyze the survival data. In some comparisons we noticed significant effect of mtDNA on desiccation resistance, while all of them showed significant effect of interaction between mitochondrial and nuclear genome. Temperature in interaction with mtDNA or mito-nuclear genotype more frequently showed significant effect on desic-cation resistance compared to sex in interaction with mtDNA or mito-nuclear genotype. Our result show adaptive significance of intra-population variation of mtDNA and importance of interactions between mitochondrial and nuclear genome on fitness. Temperature specific mito-nuclear interaction rather than sex-specific selection on mito-nuclear genotypes maintains mtDNA variability in this model species.
Using BBC Learning English Podcasts to develop university students’ listening skills

The emergence of podcasts in an English foreign language (EFL) setting is seen as a helpful aid to foreign language learning. Using podcasts might help improve language learning efficiency. This research addresses how podcasts can be an alternative means of improving English listening comprehension for university students. The study was carried out at Nizhyn Gogol State University, Ukraine, using quantitative and qualitative methods of analyzing data. To collect the data, research tools such as a questionnaire, initial and final testing, and observation were used. The procedure was introduced for a group of first-year students and implemented for six weeks. Special BBC Learning English podcast activities were designed and offered to the students. The main stages have been specified in the process of developing students’ listening skills. In the pre-listening stage, students do preparation activities to prepare for the podcast using their background knowledge. The while-listening stage is aimed at listening for gist, listening for details, making inferences, and summarizing. In the post-listening stage, the listeners are taken beyond the podcast content and set tasks which contribute to integrating other language skills. Samples of activities which correspond to these three stages are provided. A balanced approach to choosing top-down or bottom-up processing within the stages improves the process of forming competencies in listening of first-year students. Hence, based on the positive results of this study, BBC Learning English podcasts with meaningful, appropriate, and interesting activities attract the students’ attention, increase their motivation, and improve their listening comprehension.