Miracle-dz/UniFAR-FTUs huggingface dataset:
Physiological and Psychological Responses of Viewing a Waterfall Image: A Crossover Study

Growing interest in the relaxation effect of nature has elicited demands for scientific verification of the various natural elements. This study investigated the physiological and psychological responses of 27 females in their 20 s to viewing a waterfall and urban images (control) presented via a large, high-resolution display for 90 s. High-frequency [HF] for parasympathetic nervous activity and the ratio of low-frequency (LF)/[LF + HF] for sympathetic nervous activity by heart rate variability and heart rate were recorded. Simultaneous changes in oxyhemoglobin concentration in the prefrontal cortex were recorded by near-infrared time-resolved spectroscopy. The modified semantic differential method and Profile of Mood States Second Edition were used to assess the psychological effects on the participants after viewing each image. The results showed that viewing the waterfall image, compared with viewing the urban image, (1) increased sympathetic nervous activity; (2) provided comfortable, relaxed, and natural impressions; (3) improved mood states. In conclusion, visual contact with a waterfall image physiologically activated sympathetic nervous activity and psychologically evoked positive moods and feelings.
Synthesis and Cytotoxicity Evaluation of Novel Coumarin–Palladium(II) Complexes against Human Cancer Cell Lines

Two newly synthesized coumarin–palladium(II) complexes (C1 and C2) were characterized using elemental analysis, spectroscopy (IR and 1H-13C NMR), and DFT methods at the B3LYP-D3BJ/6-311+G(d,p) level of theory. The in vitro and in silico cytotoxicity of coumarin ligands and their corresponding Pd(II) complexes was examined. For in vitro testing, five cell lines were selected, namely human cervical adenocarcinoma (HeLa), the melanoma cell line (FemX), epithelial lung carcinoma (A549), the somatic umbilical vein endothelial cell line (EA.hi926), and pancreatic ductal adenocarcinoma (Panc-1). In order to examine the in silico inhibitory potential and estimate inhibitory constants and binding energies, molecular docking studies were performed. The inhibitory activity of C1 and C2 was investigated towards epidermal growth factor receptor (EGFR), receptor tyrosine kinase (RTK), and B-cell lymphoma 2 (BCL-2). According to the results obtained from the molecular docking simulations, the inhibitory activity of the investigated complexes towards all the investigated proteins is equivalent or superior in comparison with current therapeutical options. Moreover, because of the low binding energies and the high correlation rate with experimentally obtained results, it was shown that, out of the three, the inhibition of RTK is the most probable mechanism of the cytotoxic activity of the investigated compounds.
Accuracy of high definition near infrared transillumination camera in detection of hidden proximal caries

Background Early caries detection became mandatory in modern dentistry. However, the traditional methods in caries detection had many limitations. Hence,a novel approach based on Near Infrared technology was introduced to overcome such limitations. Material and Methods Proximal surfaces of 102 posterior teeth from 36 adult participants who fulfilled the eligibility criteria were assessed by two examiners using three diagnostic methods. Teeth were examined visually according to the criteria of the International Caries Detection and Assessment System (ICDAS-II) then examined by bitewing digital radiograph (BW) and near infrared light transillumination (NIRT) camera (Vista Proxi iX HD smart). Inter and intra observer agreements were assessed using Kappa test.Dignostic accuracy parameters and Area Under the ROC curve (AUROC) with 95% confidence interval (95% CI) were evaluated for the different caries assessment methods. Results The results of inter-observer agreement showed an excellent agreement in the different groups. There was a statistically significant difference in the score distribution between ICDASII and VistaCam modalities (P-value <0.05). While there was no statistically significant difference in the score distribution between bitewing radiography and VistaCam modalities (P-value >0.05). ROC curve analysis revealed that VistaCam when compared with ICDASII had sensitivity (99.0%), specificity (50.0 %), diagnostic accuracy (98.0%) and Area under the ROC curve (AUC) was 0.745 with 95% Confidence Interval (0.649 – 0.826). When VistaCam compared with bitewing radiography, it showed sensitivity (100.0%); specificity (40.0%), diagnostic accuracy (97.1%) and AUC (0.700) with 95% confidence interval (0.601 – 0.787). Conclusions NIRT based diagnostic modality is a promising method for detection of hidden proximal lesions overcoming the hazards of radiograph. Key words:Bitewing radiography , ICDAS II , Near-infrared transillumination, proximal caries, VistaCam® iX Proxi.
CARMENES. I: instrument and survey overview

CARMENES (Calar Alto high-Resolution search for M dwarfs with Exo-earths with Near-infrared and optical Echelle Spectrographs) is a next-generation instrument for the 3.5m telescope at the Calar Alto Observatory, built by a consortium of eleven Spanish and German institutions. The CARMENES instrument consists of two separate échelle spectrographs covering the wavelength range from 0.55 μm to 1.7 μm at a spectral resolution of R = 82, 000, fed by fibers from the Cassegrain focus of the telescope. Both spectrographs are housed in temperature-stabilized vacuum tanks, to enable a long-term 1 m/s radial velocity precision employing a simultaneous calibration with Th-Ne and U-Ne emission line lamps. CARMENES has been optimized for a search for terrestrial planets in the habitable zones (HZs) of low-mass stars, which may well provide our first chance to study environments capable of supporting the development of life outside the Solar System. With its unique combination of optical and near-infrared ´echelle spectrographs, CARMENES will provide better sensitivity for the detection of low-mass planets than any comparable instrument, and a powerful tool for discriminating between genuine planet detections and false positives caused by stellar activity. The CARMENES survey will target 300 M dwarfs in the 2014 to 2018 time frame.
Research on Co-Opetition Mechanism between Pharmaceutical Enterprises and Third-Party Logistics in Drug Distribution of Medical Community

Third-party logistics (3PL) has a relatively perfect distribution system in solving the drug distribution of the medical community and optimizing the distribution efficiency of pharmaceutical enterprises, and it has gradually become an indispensable component of drug distribution. By constructing the co-opetition model of “Pharmaceutical Enterprises—3PL”, this paper explores the game strategy choice between pharmaceutical enterprises and 3PL for the solution of drug distribution under the condition of information asymmetry, and it puts forward some suggestions to improve the competition and cooperation mechanism between pharmaceutical enterprises and 3PL in drug distribution in the medical community.
Physical Therapy Management of Postacute Sequelae of COVID-19 in Outpatient Settings: A Scoping Review

Purpose: The devasting effects of the coronavirus disease 2019 (COVID-19) pandemic have warranted the rapid development of evidence surrounding the physical therapy (PT) management of the disease within inpatient settings. However, the medical community is still working to define the long-term effects of COVID-19, referred to as Postacute Sequalae of SARS-CoV-2 (PASC), and ways for physical therapists to manage them in outpatient settings. The primary objective of this review was to summarize the available evidence related to the PT management of PASC in outpatient settings. Methods: A systematic search in PubMed, Cumulative Index to Nursing and Allied Health Literature, Cochrane CENTRAL, Academic Search Complete, and MedLine yielded systematic and scoping reviews and randomized controlled trials, among others. Data extraction was performed independently by 2 reviewers with 8 studies included. Results: Only 3 publications were specific to the outpatient setting area, with 5 more studies that focused on outpatient practice as part of a multisetting study, or the postacute setting. Although the limited number and quality of publications creates challenges applying the interventions provided across a population, each were specific to PASC. Conclusions: This review supports the need for further research focused on the PT management of patients who are experiencing PASC in outpatient settings.
The Effect of the VAKVID E-Booklet (Electronic Booklet of the Covid-19 Vaccine) on Knowledge and Attitude of Understanding the Covid-19 Vaccine

There are many pros and cons to the government's policy regarding the Covid-19 Vaccine for students in schools. Low knowledge and understanding of the Covid-19 vaccine are one of the causes. Socialization and education related to the Covid-19 Vaccine are one of the efforts to support this vaccination program. The purpose of this study is to determine the influence of education using the E-Booklet VAKVID (Electronic Covid-19 Vaccine Booklet) on knowledge and attitudes of Understanding the Covid-19 Vaccine. Pre-Experimental Research with the design of One group pretest-posttest used a purposive sampling technique in sampling as many as 230 students of Madrasah Tsanawiyah (Junior Hogh School) Lhokseumawe City, knowledge and attitudes of understanding the Covid-19 vaccine were measured using questionnaires, analyzed through statistical tests Shapiro Wilk continued with the Wilcoxon test. The data from the study showed that there were differences in knowledge and attitudes of understanding the COVID-19 vaccine before and after education using the VAKVID e-Booklet. The average knowledge pretest score is 5.34±1.398 and the post-test score is 6.93±0.960, while the Attitude pretest score is 15.00±1.884 and the post-test score is 16.33±0.923. The influence of education using the VAKVID E-Booklet method provides a significant difference in knowledge (p = 0.000) and attitudes (p = 0.000) regarding Understanding the Covid-19 Vaccine. Education using the e-Booklet VAKVID method can increase knowledge and attitudes of understanding the Covid-19 vaccine in students. Abstrak: anyak pro dan kontra terhadap kebijakan pemerintah terkait Vaksin Covid-19 untuk siswa di sekolah. Pengetahuan dan sikap pemahaman vaksin Covid-19 yang rendah merupakan salah satu penyebabnya. Sosialisasi dan edukasi terkait Vaksin Covid -19 merupakan salah satu upaya dalam mendukung program vaksinasi ini . Tujuan penelitian ini untuk mengetahui pengaruh edukasi menggunakan metode E-Booklet VAKVID (Elektronik Booklet Vaksin Covid-19) terhadap pengetahuan dan sikap Pemahaman Vaksin Covid-19. Penelitian Pre Eksperimental dengan desain One group pretest-posttest ini menggunakan teknik purposive sampling dalam pengambilan sample sebanyak 230 siswa Madrasah Tsanawiyah Kota Lhokseumawe, pengetahuan dan sikap pemahaman vaksin Covid-19 diukur menggunakan kuesioner, dianalisis melalui uji statistik Shapiro Wilk dilanjutkan uji Wilcoxon.Data hasil penelitian menunjukkan terjadi perbedaan pengetahuan dan sikap pemahaman vaksin Covid-19 sebelum dan sesudah edukasi menggunakan metode e-Booklet VAKVID. Rerata skor pretest pengetahuan adalah 5,34±1,398 dan skor posstest 6.93±0,960, sedangkan skor pretest Sikap adalah 15,00±1,884 dan skor posttest 16,33±0,923. Pengaruh edukasi menggunakan metode E-Booklet VAKVID memberikan perbedaan yang signifikan terhadap pengetahuan (p=0,000) dan sikap (p=0,000) Pemahaman Vaksin Covid-19. Edukasi menggunakan metode e-Booklet VAKVID dapat meningkatkan pengetahuan dan sikap pemahaman vaksin Covid-19 pada siswa.
Disparities in survival outcomes among Black patients with HPV‐associated oropharyngeal cancer

Patients with human papillomavirus‐associated oropharyngeal squamous cell carcinoma (HPV‐OPSCC) have a favorable prognosis and excellent overall survival (OS), and studies have demonstrated these findings in cohorts of predominantly White patients. Racial/ethnic (R/E) minorities, particularly Black patients, with head and neck squamous cell carcinoma (HNSCC) have worse survival outcomes compared with White patients. In this study, we aimed to determine if Black patients with HPV‐OPSCC have a similar favorable prognosis to the White population. This was a population‐based retrospective cohort study that analyzed HNSCC patients using the National Cancer Database from 2010 to 2016. We identified patients with Stage I–IV HPV‐ OPSCC who were treated with radiation, surgery, chemotherapy, or a combination of modalities. Patient outcomes were stratified by R/E groups including White Versus Black patients. The main outcome in this study was OS. Analyses for proportions of categorical variables were performed using a χ2 or Fisher's exact test. Univariate and multivariate time‐to‐event survival analyses were performed using Kaplan–Meier product limit estimates and log‐rank test to test the differences between strata. A Cox proportional hazards regression model was used to assess the association between covariates and risk of death (OS). We identified 9256 OPSCC patients who met inclusion criteria and were treated between 2010 and 2016, of which 7912 were White (85.5%) and 1344 were Black (14.5%). A total of 1727 were HPV‐OPSCC, of which 1598 were White (92.5%) and 129 (7.5%) were Black. By race, the 5‐year OS for White versus Black OPSCC patients was 42% versus 23%, respectively (log‐rank, p < 0.0001). Among HPV‐positive OPSCC patients, the 5‐year OS for White versus Black patients was 65% versus 39% (log‐rank, p < 0.0001). Among HPV‐negative patients, the 5‐year OS for White versus Black patients was 36% versus 13% (log‐rank, p < 0.0001). On multivariate analysis, after accounting for age, sex, insurance status, income, Charlson–Deyo score, receipt of surgery, distance from facility, and total treatment time, Black race trended toward, but was not associated with worse survival. Hazard ratio (HR:1.24, 95% confidence interval [CI] 0.85–1.81, p = 0.255). This national cohort study of OPSCC patients demonstrates that Black patients with HPV‐OPSCC have a poor prognosis and OS similar to HPV‐negative White patients. This may be partly due to socioeconomic barriers such as insurance and income. Further work is needed to better understand the specific drivers of inferior survival outcomes in this specific patient population.
Imaging patterns of wall thickening type of gallbladder cancer

Gallbladder cancer (GBC) has a high incidence in certain geographical regions. Morphologically, GBC presents as a mass replacing the gallbladder, a polypoidal lesion, or wall thickening. The incidence of preoperative diagnosis of wall thickening type of GBC is less well studied. The patterns of mural involvement and extramural spread are not well described in the literature. Additionally, wall thickening in the gallbladder does not always indicate malignancy and can be secondary to inflammatory or benign gallbladder diseases and extracholecystic causes and systemic pathologies. Objective reporting of gallbladder wall thickening will help us appreciate GBC’s early features. In this review, we illustrate the imaging patterns of wall thickening type of GBC.
The Operational Recognition of Supercell Thunderstorm Environments and Storm Structures

Abstract Supercell thunderstorm forecasting and detection is discussed, in light of the disastrous weather events that often accompany supercells. The emphasis is placed on using a scientific approach to evaluate supercell potential and to recognize their presence rather than the more empirical methodologies (e.g., “rules of thumb”) that have been used in the past. Operational forecasters in the National Weather Service (NWS) can employ conceptual models of the supercell, and of the meteorological environments that produce supercells, to make operational decisions scientifically. The presence of a mesocyclone is common to all supercells, but operational recognition of supercells is clouded by the various radar and visual characteristics they exhibit. The notion of a supercell spectrum is introduced in an effort to guide improved operational detection of supercells. An important part of recognition is the anticipation of what potential exists for supercells in the prestorm environment. Current scientific u.
The Effect of Added Moringa Leaves (Moringa oleifera L.) and Quail Eggs (Coturnix-coturnix japonica) on Wingko as A Snack for Anemia

This study aims to (1) determine the effect of adding moringa leaves and quail eggs to the preference level for wingko, which includes color, aroma, texture, and taste as snacks for anemia patients; (2) determine the nutritional value of the best product through wingko organoleptic test by examining the influence of adding moringa leaves and quail eggs. The research employed a pure experimental design using a 3x2 factorial design with 6 treatments. In this study, the K factor was used as the addition of moringa leaves with level 3, and the P factor was the addition of quail eggs with 2 levels. The results showed that: (1) wingko with the addition of 20% moringa leaves and 20% quail eggs was favored by the panelists based on the De Garmo test, with a productivity value of 0.88. By employing the Kruskal-Wallis test and Mann-Whitney test, this study has confirmed that the proportion of added moringa leaves and quail eggs affects the aroma, color, and taste of wingko; (2) the nutritional value of the best wingko contains 7.63% protein based on Kjeldah test, 43.97% carbohydrates based on Luff Schriool test, 12.45% fat based on direct extraction test, and 4.37 mg iron(Fe) as identified in atomic absorption spectrometer test; (3) the addition of 20% moringa leaf wingko and 20% quail eggs in 100 grams could meet the requirement of protein, carbohydrates, fat, and iron.
COMPARATIVE WATER VAPOR MEASUREMENTS FOR INFRARED SITES

Water-vapor measurements are reported for Chacaltaya north of La Paz, Bolivia, and for Mount Lemmon Infrared Ohservatory. Comparisons are presented for Mauna Kea, Cerro Tololo, and the Wyoming site. All hut Cerro Tololo are at least class-B sites (13 mm 1120) most of the year. CTIO is a class-C site ( 3mm 1120) approximately one-half of the , while Mount Lemmon is a classic-C site two months of the year. Wyoming is seen as the hest class-A site ( 1 mm 1120) followed hy Mauna Kea. It is concluded that Chacaltaya could serve as a good high-altitude infrared site in the Southern Hemisphere. Key words: water-vapor measurements-infrared sites
Do We Abuse Drugs? Reports of Social Studies and Early Childhood Education Student-Teachers in two Nigerian Colleges of Education

The study investigated the incidence of drug abuse among student-teachers in two Nigerian colleges of education. The study’s population comprised all NCE II and III Social Studies and Early Childhood Education student-teachers in two colleges located in Oyo State, Nigeria. Data was analysed using frequency counts, percentage, mean and standard deviation. Of the 400 student-teachers, 213(53.3%) were male while 187(46.8%) were female. Only 148(37%) were from Early Childhood Education while 252(63%) were from Social Studies. The student-teachers may exert negative influence on young children when they eventually take up appointment as teachers in pre-primary and primary schools. Departments of Social Studies and Early Childhood Education together with the colleges counseling centers should organize regular counseling activities and services to educate the pre-service teachers about the danger and implications that could result from their involvement in abuse of drugs.
Microbiota-Based Live Biotherapeutic RBX2660 for the Reduction of Recurrent Clostridioides difficile Infection in Older Adults With Underlying Comorbidities

Abstract Background Advanced age and underlying comorbidities are associated with greater rates of recurrence in patients with Clostridioides difficile infection (CDI). Reducing the likelihood of recurrence through treatment with an antimicrobial followed by a microbiota replacement therapy can decrease the burden of this infection and improve patient outcomes. We report the efficacy and safety of RBX2660, a microbiota-based live biotherapeutic, in older adults with recurrent CDI, grouped by comorbidities. Methods In this post hoc subgroup analysis of the PUNCH CD3 trial, we assessed outcomes in older adults (age ≥65 years) grouped by Charlson Comorbidity Index severity scores at screening (moderate [3–4] and severe [≥5]) and by the presence of underlying cardiac, renal, or gastrointestinal disorders. Results RBX2660 treatment success rates in older adults with comorbidities were consistent across subgroups and similar to those in the total RBX2660-treated population. A greater percentage of RBX2660-treated older adults remained free of CDI recurrence through 8 weeks following treatment compared with placebo-treated participants in all but 2 subgroups assessed. Across all subgroups, most treatment-emergent adverse events (TEAEs) were mild or moderate in severity and related to a preexisting condition. None of the serious or life-threatening TEAEs that occurred were related to RBX2660 or its administration. Occurrence of TEAEs did not cluster in any subgroup. Conclusions RBX2660 is efficacious and safe in older adults with recurrent CDI and underlying comorbidities.
A parameter estimation approach to time-delay estimation and signal detection

Present techniques that estimate the difference in arrival time between two signals corrupted by noise, received at two separate sensors, are based on the determination of the peak of the generalized cross correlation between the signals. To achieve good resolution and stability in the estimates, the input sequences are first weighted. Invariably, the weights are dependent on input spectra which are generally unknown and hence have to be estimated. By approximating the time shift as a finite impulse response filter, estimation of time delay becomes one of determination of the filter coefficients. With this formulation, a host of techniques in the well-developed area of parameter estimation is available to the time-delay estimation problem-with the possibilities of reduced computation time as compared with present methods. In particular, it is shown that the least squares estimation of the filter coefficients is equivalent to estimating the Roth processor. However, the parameter estimation approach is expected to have a smaller variance since it avoids the need for spectra estimation. Indeed, experimental results from two examples show that the Roth processor, found by least squares parameter estimation, has a smaller variance than the approximate maximum likelihood estimator of Hannan-Thomson where spectral estimation is required. A detector that uses the sum of the estimated parameters as a test statistic is also given, together with its receiver operating characteristics.