Miracle-dz/UniFAR-FTUs huggingface dataset:
AAID White Paper: Management of the Dental Implant Patient During the COVID-19 Pandemic and Beyond

The scientific community's understanding of how the SARS-CoV-2 virus is transmitted and how to best mitigate its spread is improving daily. To help protect patients from acquiring COVID-19 from a dental office nosocomial infection, many state or local governments have classified dental treatments as "nonessential" and have paused routine dental care. Dentists have been instructed to perform only procedures designated as emergencies. Unfortunately, there is not a good understanding of what a dental emergency is among governmental leaders. What a government agency may perceive as an elective procedure may be seen as "essential" by the dental clinician responsible for maintaining the oral health of the patient. Each dental specialty understands the effects delayed care has on a patient's oral and systemic health. Dentistry has made extensive progress in improving oral health through prevention of the dental emergency. The dental profession must work together to prevent the reversal of the progress dentistry and patients have made. This American Academy of Implant Dentistry (AAID) White Paper discusses what COVID-19 is and how it impacts dental treatments, presents guidelines for dentistry in general and for dental implant related treatments, specifically. Recommendations for implant dentistry include the following: (1) what constitutes a dental implant related emergency, (2) how patients should be screened and triaged, (3) what personal protective equipment is necessary, (4) how operatories should be equipped, (5) what equipment should be used, and (6) what, when, and how procedures can be performed. This paper is intended to provide guidance for the dental implant practice so patients and dental health care providers can be safe, and offices can remain open and viable during the pandemic.
Apocrine Gland e Rich Skin Has a Non-Inﬂammatory IL-17 e Related Immune Milieu, that Turns to Inﬂammatory IL-17 e Mediated Disease in Hidradenitis Suppurativa

Takeuchi H, Kantharia J, Sethi MK, Bakker H, Haltiwanger RS. Site-specific O-glucosylation of the epidermal growth factor-like (EGF) repeats of notch: efficiency of glycosylation is affected by proper folding and amino acid sequence of individual EGF repeats. J Biol Chem 2012;287:33934e44. Yasumoto K, Yokoyama K, Shibata K, Tomita Y, Shibahara S. Microphthalmia-associated transcription factor as a regulator for melanocytespecific transcription of the human tyrosinase gene. Mol Cell Biol 1995;15:1833.
Effects of short-term exposure of feeder cattle to calves persistently infected with bovine viral diarrhea virus

Research using 2,954 auction-derived feeder steers and heifers was conducted at a single commercial feedlot in Kansas to determine the effects of testing for cattle persistently infected (PI) with bovine viral diarrhea virus (BVDV) at 10-14 days-on-feed (DOF), and removing them at 13-18 DOF. After removal of test-positive animals, the effect of the short-term exposure (STE) to PI cattle on health, performance and carcass characteristics was determined. The percentage of calves exhibiting signs of illness was increased (P<0.01) in cattle with STE to PI-BVDV. Cattle with no exposure (NE) to PI-BVDV calves had a morbidity rate of 18.8%, while a 29.6% morbidity rate was observed in pens of calves with STE to a PI-BVDV calf. Characterization of the temporal pen morbidity rate of STE and NE calves revealed that 31.7% of all STE and 15.3% of NE illness occurred in the first seven DOF. Additionally, the incidence of cattle treated for bovine respiratory disease in STE calves was 2.17 (95% CI 1.73 to 2.72) initial treatments per 1,000 head-days at risk, whereas the incidence of treatment of calves in NE pens was 1.28 (95% CI 0.98 to 1.68) initial treatments per 1,000 head-days at risk. Short-term exposure to PI-BVDV calves had no effect on retreatment rate, death loss, or performance. There was no evidence of a BVD-PI exposure X sex interaction (P=0.62) for carcasses that graded USDA Choice or better, but there was a main effect of sex (P<0.01). There was evidence of a BVD-PI exposure X sex interaction for Yield Grade 2 or greater carcasses (P=0.03). In this study, testing at 10-14 DOF was too late in the feeding period to eliminate the initial morbidity spike that occurred during 0-7 DOF, and the subsequent morbidity differences between calves with STE or NE to PI calves.
A Study on the Difficulty of Accounting for Data Processing in Functional Size Measures

—The most popular Functional Size Measurement methods adopt a concept of “functionality” that is based mainly on the data involved in functions and data movements. Functional size measures are often used as a basis for estimating the effort required for software development. However, Functional Size Measurement does not take directly into consideration the amount of data processing involved in a process, even though it is well-known that development effort does depend on the amount of data processing code to be written. Thus, it is interesting to investigate to what extent the most popular functional size measures represent the data processing features of requirements and, consequently, the amount of data processing code to be written. To this end, we consider three applications that provide similar functionality, but require different amounts of data processing. These applications are then measured via a few Functional Size Measurement methods and traditional size measures (such as Lines of Code). A comparison of the obtained measures shows that differences among the applications are best represented by differences in Lines of Code. It is likely that the actual size of an application that requires substantial amounts of data processing is not fully represented by functional size measures. In summary, the paper shows that not taking into account data processing dramatically limits the expressiveness of the functional size measures. Practitioners that use size measures for effort estimation should complement functional size measures with measures that quantify data processing, to obtain precise effort estimates.
JPET#52696 1 Reversal of Multiple Drug Resistance in Cholangiocarcinoma by the GST- Specific Inhibitor: O-Hexadecyl γ-glutamyl-S-benzylcysteinyl-D-phenylglycine ethylester

Cholangiocarcinoma is markedly resistant to chemotherapy and has a dismal prognosis, but its mechanism of drug resistance is unknown. This study examines whether Glutathione S-transferase*673 -1) is involved in resistance to anticancer drugs in cholangiocarcinoma and whether GSTP1-1 specific inhibitors can overcome this resistance. First, immunohistochemical examination disclosed strong staining of all our 17 cholangiocarcinoma specimens for GSTP1-1, irrespective of histological type. Transfection of the GSTP1-1 antisense expression vector into a human cholangiocarcinoma cell line (HuCCT1) apparently decreased its intracellular GSTP1-1 concentration, and the sensitivity of transfectants to adriamycin (ADR), cisplatin and alkylating agents such as melphalan and 4-hydroxyperoxycyclophosphamide (4-HC) was increased significantly, compared to that of mock-transfectants. We next synthesized GSTP1-1 specific inhibitors by elongating the carbon chain of the ethylester at the N-terminal of γ-glutamyl-S-benzylcysteinyl-phenylglycyl diethylester and performed a pharmacokinetic study on them. Of six GSTP1-1 inhibitors tested, O-hexadecyl-γ-glutamyl-S-benzylcysteinyl-D-phenylglycine ethylester (C16C2) This article has not been copyedited and formatted. The final version may differ from this version. JPET Fast Forward. Published on June 12, 2003 as DOI: 10.1124/jpet.103. 052696 at A PE T Jornals on A uust 4, 2017 jpet.asjournals. org D ow nladed from
Assessing the impact path of air quality on enterprise R&D investment: Empirical evidence from dual perspectives of investor sentiment and government concern

Based on the data of Shanghai and Shenzhen A-share listed companies from 2015 to 2019, this paper studies the influence of air quality on the R&D investment of listed companies from the perspectives of investor sentiment and government concern. It is found that, on the whole, air quality has a significant inhibitory effect on R&D investment. Air quality significantly promotes investor sentiment, which serves as a path to further restrain the R&D investment of listed companies. Air pollution is an effective concern for the government and serves as a veil between air quality and R&D investment. Furthermore, this paper analyzes the heterogeneity of enterprises from the aspects of regional technology complexity, property right nature, whether it is a polluting enterprise or not, and whether it is a key regulated enterprise or not, and comes to relevant conclusions. This paper expands the research on air quality and enterprise R&D investment decision-making, which helps to clarify and improve the transmission mechanism and implementation effect of environmental protection policies.
OTT_A_256291 7447..7458

1Department of the 2nd Thoracic Surgery, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, People’s Republic of China; 2Hunan Key Laboratory of Translational Radiation Oncology, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, People’s Republic of China; 3Department of Pharmacy, Xiangya Hospital of Xiangya School of Medicine, Central South University, Changsha, People’s Republic of China; 4Department of Pharmacy, The First People’s Hospital of Yue Yang, Yue Yang, People’s Republic of China; 5Department of Pharmacy, The SecondAffiliatedHospital of Hunan University of Chinese Medicine, Changsha, People’s Republic of China Background: Parthenolide (PT), the effective active ingredient of the medicinal plant, feverfew (Tanacetum parthenium), has been used as an anti-inflammatory drug due to its involvement in the inhibition of the NF-кB pathway.Moreover, recent studies have demonstrated the anti-tumor effect of PT in several cancers. However, the effect of PT on esophageal carcinoma remains unclear to date. In this study, we examined the inhibitory effects of PTand its underlyingmechanism of action in human esophageal squamous cell carcinoma (ESCC) cells – Eca109 and KYSE-510. Methods: The proliferation ability of Eca109 and KYSE-510 treated with PT was detected using the Cell Counting Kit-8 and colony forming assay. The Transwell assay and the wound healing assay were used to analyze the cell invasion and migration ability, respectively. The tube formation assay was used to investigate the effect of PT on tube formation of endothelial cells. The expression level of NF-кB, AP-1 and VEGF was analyzed by Western blot. Results: We demonstrated that PT attenuates the proliferation and migration ability of ESCC cells in vitro and also inhibits tumor growth in the mouse xenograft model. In addition, PT exhibited anti-angiogenesis activity by weakening the proliferation, invasion and tube formation of endothelial cells in vitro and reduced microvessel density in the xenograft tumors. Further studies revealed that PT reduced the expression level of NF-кB, AP-1 and VEGF in ESCC cells. Conclusion: Collectively, the results of our study demonstrated that PT exerts anti-tumor and anti-angiogenesis effects possibly by inhibiting the NF-кB/AP-1/VEGF signaling pathway on esophageal carcinoma and might serve as a promising therapeutic agent for ESCC.
The E ﬀ ects of Business Strategy and Inventory on the Relationship between Sales Manipulation and Future Proﬁtability

: Many researchers have found that real activities manipulation undermines future proﬁtability, because it deviates from normal operating activities. We are interested in sales manipulation, which is one type of real activities manipulation relating to corporate sustainability. First, we empirically examine whether the e ﬀ ects of sales manipulation on future proﬁtability di ﬀ er according to the strategies of a ﬁrm. Next, we divide sales manipulation as a type of real activities manipulation and optimal sales manipulation and then examine how the two types of sales manipulation a ﬀ ect future proﬁtability. Finally, we examine how the e ﬀ ects of optimal sales manipulation on future proﬁtability di ﬀ er according to the ﬁrm’s strategies. The empirical ﬁndings show that the association between sales manipulation and future proﬁtability is more negative ( − ) for a product di ﬀ erentiation strategy than for a cost leadership strategy. Further, the sales manipulation performed by ﬁrms with a high proportion of the starting inventory and a decrease in the inventory during the current year has a positive ( + ) impact on future proﬁtability. Our results contribute to the literature on business strategy by presenting evidence that core management activities are related to future ﬁnancial performance, according to the business strategy. In addition, our research shows that sales manipulation can turn into an optimal operating activity, depending on the ﬁrm’s situation. suggests the results indicate that the
Optimal design of implants for magnetically mediated hyperthermia: A wireless power transfer approach

In magnetically mediated hyperthermia (MMH), an externally applied alternating magnetic field interacts with a mediator (such as a magnetic nanoparticle or an implant) inside the body to heat up the tissue in its proximity. Producing heat via induced currents in this manner is strikingly similar to wireless power transfer (WPT) for implants, where power is transferred from a transmitter outside of the body to an implanted receiver, in most cases via magnetic fields as well. Leveraging this analogy, a systematic method to design MMH implants for optimal heating efficiency is introduced, akin to the design of WPT systems for optimal power transfer efficiency. This paper provides analytical formulas for the achievable heating efficiency bounds as well as the optimal operating frequency and the implant material. Multiphysics simulations validate the approach and further demonstrate that optimization with respect to maximum heating efficiency is accompanied by minimizing heat delivery to healthy tissue. This i.
Long-term follow-up of trauma patients before and after implementation of a Physician-Staffed Helicopter

Methods: Prospective, observational study with a maximum follow-up time of 4.5 years. Trauma patients from a 5-month period prior to the implementation of HEMS (pre-HEMS) were compared with patients from the ﬁrst 12 months after implementation (post-HEMS). All analyses were adjusted for sex, age and Injury Severity Score. Results: Of the total 1994 patients, 1790 were eligible for mortality analyses and 1172 ( n = 297 pre- HEMS and n = 875 post-HEMS) for labour market analyses. Incidence rates of involuntary early retirement or death were 2.40 per 100 person-years pre-HEMS and 2.00 post-HEMS; corresponding to a hazard ratio (HR) of 0.72 (95% conﬁdence interval (CI) 0.44–1.17; p = 0.18). The HR of involuntary early retirement was 0.79 (95% CI 0.44–1.43; p = 0.43). The prevalence of reduced work ability after three years were 21.4% vs. 17.7%, odds ratio (OR) = 0.78 (CI 0.53–1.14; p = 0.20). The proportions of patients on social transfer payments at least half the time during the three-year period were 30.5% vs. 23.4%, OR = 0.68 (CI 0.49–0.96; p = 0.03). HR for mortality was 0.92 (CI 0.62–1.35; p = 0.66). Conclusions: The implementation of HEMS was associated with a signiﬁcant reduction in time on social transfer payments. No signiﬁcant differences were found in involuntary early retirement rate, long-term mortality, or work ability. (cid:2)
Level of Knowledge of Obstetric Warning Signs in Pregnant Women of a Primary Care Unit in Tijuana

Background: The causes of maternal morbidity and mortality reported worldwide are preventable conditions, there are multiple factors associated with the occurrence of these events. The knowledge of obstetric warning signs improves the early detection of problems and reduces the delay in emergency obstetric care, reducing the risk of developing complications. Any obstetric warning sign that occurs during pregnancy should be detected. Aim: The purpose of this study is to determinate the level of knowledge of obstetric warning signs in pregnant women in Tijuana, Mexico. Design and Setting: Descriptive cross-sectional study. Methods: In 146 patients in the Family Medicine Unit #27, Tijuana, Mexico, a descriptive cross-sectional study was conducted in pregnant patients. We obtained general data such as age, schooling, marital status, number of consultations, stage of pregnancy, number of pregnancies, attitude towards obstetric warning signs, diffusion way of information and level of knowledge of obstetric warning signs. For statistical analysis, we applied descriptive statistics; for qualitative variables frequencies and percentages were used and for quantitative variables mean and standard deviation. Results: The high level of knowledge among pregnant patients was 52% (n=76), medium level 32% (n=46) and low level 16% (n=23). Conclusion: It is necessary to strengthen prenatal care and involve patients in health care.
Arguing with Behavior In°uence: A Model for Web-Based Group Decision Support Systems

In this work, we propose an argumentation-based dialogue model designed for Web-based Group Decision Support Systems, that considers the decision-makers' intentions. The intentions are modeled as behavior styles which allow agents to interact with each other as humans would in face-to-face meetings. In addition, we propose a set of arguments that can be used by the agents to perform and evaluate requests, while considering the agents' behavior style. The inclusion of decision-makers' intentions intends to create a more reliable and realistic process. Our model proved, in di®erent contexts, that higher levels of consensus and satisfaction are achieved when using agents modeled with behavior styles compared to agents without any features to represent the decision-makers' intentions.
Activating Mutations of the G s a Gene Are Associated with Low Levels of Gs a Protein in Growth Hormone-Secreting Tumors*

Evidence suggests the existence of a direct relationship between cellular G s a content and activation of the adenylyl cyclase system. Data on G s a levels in endocrine tumors that depend on cAMP for growth, particularly pituitary adenomas, are still limited. The levels of G s a protein were evaluated in 11 GH-secreting adenomas with G s a mutations ( gsp 1 ) and 15 without ( gsp ). Complementary DNAs from gsp 1 tumors contained very low amounts of wild-type G s a sequences, indicating a preponderance of the mutant G s a transcripts in these tumors. Immunoblotting of G s a protein showed that the two isoforms werepresentathighlevelsinall gsp 2 ,butwereundetectableorbarely detectable in gsp 1 . The low G s a content in gsp 1 tumors was not due to a reduction in ribonucleic acid synthesis or stability, as G s a messenger ribonucleic acid levels were similar in wild-type and mutant tissues. Treatment of gsp 2 cells with cholera toxin caused a marked reduction of G s a levels. As in other cell systems cholera toxin in- creases G s a degradation, our data are consistent with an accelerated removal of mutant G s a . This may represent an additional mechanism of feedback response to the constitutive activation of cAMP signaling in pituitary tumors with mutations in the G s a gene. ( J Clin Endocrinol Metab 83: 4386–4390, 1998) The study was carried out on 26 GH-secreting tumors surgically removed by the transsphenoidal route from patients affected with active acromegaly. Acromegaly was diagnosed on the basis of clinical features, elevated insulin-like growth factor I plasma levels and elevated GH levelsnotsuppressibleduringoralglucosetolerancetest.Nopatienthadpreviouslyundergonepituitaryirradiation. PatientsdidnotreceivedrugsknowntoinfluenceGproteinexpression,inparticularethanol, opiates, and lithium. Small adenoma fragments were fixed for light and
Phytoplankton Do Not Produce Carbon-Rich Organic Matter in High CO 2 Oceans Geophysical Research Letters

The ocean is a substantial sink for atmospheric carbon dioxide (CO 2 ) released as a result of human activities. Over the coming decades the dissolved inorganic C concentration in the surface ocean is predicted to increase, which is expected to have a direct in ﬂ uence on the ef ﬁ ciency of C utilization (consumption and production) by phytoplankton during photosynthesis. Here we evaluated the generality of C-rich organic matter production by examining the elemental C:N ratio of organic matter produced under conditions of varying pCO 2 . The data used in this analysis were obtained from a series of pelagic in situ pCO 2 perturbation studies that were performed in the diverse ocean regions and involved natural phytoplankton assemblages. The C:N ratio of the resulting particulate and dissolved organic matter did not differ across the range of pCO 2 conditions tested. In particular, the ratio for particulate organic C and N was found to be 6.58 ± 0.05, close to the theoretical value of 6.6. study we evaluated the generality of the negative feedback hypothesis by determining the elemental ratio (C:N) obtained from a series of in situ pCO 2 perturbation studies. Our result showed that the C:N ratio of the organic matter produced did not differ across the range of pCO 2 conditions. This suggests that the proposed feedbacks that were predicted to arise from the production of disproportionally C-rich organic matter are unlikely to occur in future oceans.
The Effectiveness of Shrouding on Reducing Meshed Spur Gear Power Loss Test Results

Gearbox efficiency is reduced at high rotational speeds due to windage drag and viscous effects on rotating, meshed gear components. A goal of NASA aeronautics rotorcraft research is aimed at propulsion technologies that improve efficiency while minimizing vehicle weight. Specifically, reducing power losses to rotorcraft gearboxes would allow gains in areas such as vehicle payload, range, mission type, and fuel consumption. To that end, a gear windage rig has been commissioned at NASA Glenn Research Center to measure windage drag on gears and to test methodologies to mitigate windage power losses. One method used in rotorcraft gearbox design attempts to reduce gear windage power loss by utilizing close clearance walls to enclose the gears in both the axial and radial directions. The close clearance shrouds result in reduced drag on the gear teeth and reduced power loss. For meshed spur gears, the shrouding takes the form of metal side plates and circumferential metal sectors. Variably positioned axial and radial shrouds are incorporated in the NASA rig to study the effect of shroud clearance on gearbox power loss. A number of researchers have given experimental and analytical results for single spur gears, with and without shrouding. Shrouded meshed spur gear test results are sparse in the literature. Windage tests were run at NASA Glenn using meshed spur gears at four shroud configurations: unshrouded, shrouded (max. axial, max. radial), and two intermediate shrouding conditions. Results are compared to available meshed spur gear power loss data/analyses as well as single spur gear data/analyses. Recommendations are made for future work.