Miracle-dz/UniFAR-FTUs huggingface dataset:
Pediatric massage therapy for treatment of tic disorders in children: A systematic review and meta-analysis of randomized controlled trials

Background: Tic disorder is a common neurodevelopmental disorder in childhood, characterized primarily by motor or vocal tics. However, there is no systematic evaluation of pediatric massage therapy for children with Tic disorder. This study aims to evaluate the effectiveness and safety of massage therapy for children with tic disorder through a comprehensive meta-analysis and systematic review. Methods: We systematically searched relevant randomized controlled trials from various databases such as CBM, CNKI, VIP, Wanfang database, PubMed, Embase, Web of Science, Cochrane Library, and SINOMED, published up to October 2023. To collect randomized controlled trials on pediatric massage therapy or in combination with other therapies for the treatment of tic disorders in children. The risk of bias in the included articles was assessed using the Cochrane guideline. Meta-analyses were performed using Review Manager 5.4, and publication bias was evaluated by using Begg test and Egger test in Stata SE software. Results: This meta-analysis included 19 randomized controlled trials with 1423 patients. Pediatric massage therapy alone or in combination with conventional medication demonstrated a significant increase in clinical effectiveness rates [risk ratios = 1.15, 95% confidence interval [CI] (1.10, 1.20), Z = 6.54, P < . 001], and reduced Yale Global Tie Severity Scale scores [standardized mean difference = −0.85, 95% CI (−1.50, −0.19), Z = 2.54, P = . 01] and traditional Chinese medicine syndrome scores [standardized mean difference = −1.35, 95%CI (−2.08, −0.63), Z = 3.66, P = . 0002]. In terms of adverse reactions, there was no statistical difference between the experimental and control groups [risk ratios = 0.26, 95% CI (0.14, 0.49), Z = 4.25, P < . 001]. The Begg test and Egger test results indicated no publication bias. Conclusion: Evidence suggests that pediatric massage therapy is effective in improving tic disorders in children.
Digital Biomarker–Based Interventions: Systematic Review of Systematic Reviews

Background The introduction of new medical technologies such as sensors has accelerated the process of collecting patient data for relevant clinical decisions, which has led to the introduction of a new technology known as digital biomarkers. Objective This study aims to assess the methodological quality and quality of evidence from meta-analyses of digital biomarker–based interventions. Methods This study follows the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guideline for reporting systematic reviews, including original English publications of systematic reviews reporting meta-analyses of clinical outcomes (efficacy and safety endpoints) of digital biomarker–based interventions compared with alternative interventions without digital biomarkers. Imaging or other technologies that do not measure objective physiological or behavioral data were excluded from this study. A literature search of PubMed and the Cochrane Library was conducted, limited to 2019-2020. The quality of the methodology and evidence synthesis of the meta-analyses were assessed using AMSTAR-2 (A Measurement Tool to Assess Systematic Reviews 2) and GRADE (Grading of Recommendations, Assessment, Development, and Evaluations), respectively. This study was funded by the National Research, Development and Innovation Fund of Hungary. Results A total of 25 studies with 91 reported outcomes were included in the final analysis; 1 (4%), 1 (4%), and 23 (92%) studies had high, low, and critically low methodologic quality, respectively. As many as 6 clinical outcomes (7%) had high-quality evidence and 80 outcomes (88%) had moderate-quality evidence; 5 outcomes (5%) were rated with a low level of certainty, mainly due to risk of bias (85/91, 93%), inconsistency (27/91, 30%), and imprecision (27/91, 30%). There is high-quality evidence of improvements in mortality, transplant risk, cardiac arrhythmia detection, and stroke incidence with cardiac devices, albeit with low reporting quality. High-quality reviews of pedometers reported moderate-quality evidence, including effects on physical activity and BMI. No reports with high-quality evidence and high methodological quality were found. Conclusions Researchers in this field should consider the AMSTAR-2 criteria and GRADE to produce high-quality studies in the future. In addition, patients, clinicians, and policymakers are advised to consider the results of this study before making clinical decisions regarding digital biomarkers to be informed of the degree of certainty of the various interventions investigated in this study. The results of this study should be considered with its limitations, such as the narrow time frame. International Registered Report Identifier (IRRID) RR2-10.2196/28204
Detecting primitive hematopoietic stem cells in total nucleated and mononuclear cell fractions from umbilical cord blood segments and units Journal of Translational Medicine Sample

Detecting primitive hematopoietic stem cells in total nucleated and mononuclear cell fractions from umbilical cord blood segments and units Journal of Translational Medicine Sample doi:10.1186/s12967-015-0434-z John Patterson (jpatter5@uccs.edu) Cally H Moore (calli.moore@colorado.edu) Emily Palser (epalser@uccs.edu) Jason C Hearn (jhearn@hemogenix.com) Daniela Dumitru (ddumitru@hemogenix.com) Holli A Harper (haharper@hemogenix.com) Ivan N Rich (ivannr@hemogenix.com) Sample
Interactions between stimulus and response types are more strongly represented in the entorhinal cortex than in its upstream regions in rats

Previously we reported results which suggested that response types are critical in dissociating the lateral entorhinal cortex (LEC) from the medial entorhinal cortex (MEC) in a scene memory task (Yoo and Lee, 2017). Here, we investigated whether the perirhinal cortex (PER) and postrhinal cortex (POR), the upstream regions of the LEC and MEC, respectively, could be dissociated similarly. We conducted four tasks by combining different stimulus and response types. Our results suggest that the PER is important whenever object recognition is required and, together with prior findings, imply that PER-LEC networks are essential in goal-directed interactions with objects. The POR appears critical for recognizing visual scenes and may play key roles in scene-based navigation together with the MEC. The relative lack of functional dissociation between stimulus and response types at the PER-POR level suggests that actions conditioned on the recognition of external stimuli may be uniquely represented from the EC.
International Journal of Special Education Teacher Efficacy, Tolerance, Gender, and Years of Experience and Special Education Referrals

Teacher efficacy and teacher tolerance, along with teacher gender, were examined for their relationship with the number of students teachers referred to special education. In a sample of 167 elementary school teachers from an urban school district in the State of Texas, no statistically significant relationships were yielded between teacher tolerance and referrals made to special education; between teacher efficacy and referrals made to special education; and, between teacher years of experience and referrals made to special education. In addition, no differences were found in teacher tolerance and teacher efficacy as a function of gender. Results were not supportive of previous research studies. Implications of these findings are discussed. Teacher efficacy has been defined as the conviction that one can successfully bring about the desired outcome in one's students (Gibson & Dembo, 1984). In a study designed to develop an instrument to measure teacher efficacy, Gibson and Dembo determined that teaching could affect specific outcomes in students (teaching efficacy) and beliefs about one's own ability to bring about student improvement (personal efficacy). They found that efficacy in teachers contributed to methodology and classroom management. Teachers with differing levels of efficacy used different classroom practices such as whole class versus small group instruction and persistence levels in situations where student encounter difficulty in answering questions. Teachers with low efficacy allowed for almost twice as much time for small group instruction than teachers with high efficacy. Further, teachers with low efficacy appeared to reach a point of being flustered easier and more rapidly than their counterparts if their routine was disturbed or ignored. The number of students off-task appeared to be greater within a low-efficacy teacher's classroom than within a high efficacy teacher. In contrast, teachers with high efficacy were more effective in using cognitive and open-ended questioning strategies to probe and lead student to correct responses and reflections than teachers with low efficacy who tended to move on to another student or another question when a student showed signs of difficulty. In one of the first studies, conducted in Europe, to examine the relationship between teacher efficacy and referral to special education, Meijer and Foster (1988) found that teachers who had high personal efficacy were less likely to refer students to special education than were teachers with low personal efficacy. The findings of this study were not explored in the United States until 1993 when Podell and Soodak (1993) gave case …
Determining the hierarchical order by which the variables of sampling season , dust 1 outbreaks occurrence , and sampling location , can shape the airborne bacterial 2 communities in the Mediterranean basin 3 4 5

19 An NGS-based taxonomic analysis was carried out on airborne bacteria sampled at ground 20 level in two periods (May and September) and two opposite localities on the North-South axis 21 of the Sardinia Island. Located in a central position of the Mediterranean basin, Sardinia 22 constitutes a suitable outpost to reveal possible immigration of bacterial taxa during 23 transcontinental particle discharge between Africa and Europe. With the aim of verifying 24 relative effects of dust outbreaks, sampling period and sampling site, on the airborne bacterial 25 https://doi.org/10.5194/bg-2020-324 Preprint. Discussion started: 22 December 2020 c © Author(s) 2020. CC BY 4.0 License.
Web-based survey investigating cardiovascular complications in hypermobile Ehlers-Danlos syndrome after COVID-19 infection and vaccination

Background Hypermobile Ehlers-Danlos syndrome is a heritable connective tissue disorder associated with generalized joint hypermobility but also other multisystem comorbidities, many of which may be exacerbated during a viral illness or after a vaccination. We sought to determine whether individuals with hypermobile Ehlers Danlos syndrome report an increase in adverse events, including cardiovascular events, after COVID-19 illness or vaccination. Methods A cross-sectional web-based survey was made available from November 22, 2021, through March 15, 2022. 368 respondents primarily from the United States self-reported data including diagnosis. We used a Cox proportional hazards model with time varying indicators for COVID-19 illness or vaccination in the previous 30 days. Results We found a significantly increased rate of new abnormal heart rhythms reported in the 30 days following COVID-19 illness. No additional cardiovascular events were reported after COVID-19 illness. 2.5% of respondents with COVID-19 illness were hospitalized. We did not find a statistically significant increased rate of cardiovascular events in the 30 days following any COVID-19 vaccination dose. Post COVID-19 vaccination, 87.2% of hypermobile Ehlers-Danlos syndrome respondents endorsed an expected adverse event (EAE), and 3.1% reported an emergency department visit/hospitalization, of those who received at least one vaccine dose. Events possibly reflecting exacerbation of orthostasis/dysautonomia were common. Conclusion Respondents did not report an increased rate of any cardiovascular events in the 30 days following COVID-19 vaccination; however, those with hypermobile Ehlers-Danlos syndrome experienced a high rate of expected adverse events after vaccination consistent with a high baseline prevalence of similar symptoms. No cardiovascular events other than new abnormal heart rhythms were reported at any point after a COVID-19 illness.
Cost-utility analysis of atezolizumab combined with bevacizumab for unresectable hepatocellular carcinoma in Thailand

Background Clinical trials have proven the efficacy and safety of atezolizumab combined with bevacizumab (A+B) in treating unresectable hepatocellular carcinoma (uHCC). This study aimed to assess the cost-utility of A+B compared to best supportive care (BSC) among uHCC patients in Thailand. Methods We conducted a cost-utility analysis from a societal perspective. We used a three-state Markov model to estimate relevant costs and health outcomes over the lifetime horizon. Local cost and utility data from Thai patients were applied. All costs were adjusted to 2023 values using the consumer price index. We reported results as incremental cost-effectiveness ratios (ICERs) in United States dollars ($) per quality-adjusted life year (QALY) gained. We discounted future costs and outcomes at 3% per annum. We then performed one-way sensitivity analysis and probabilistic sensitivity analysis to assess parameter uncertainty. The budget impact was conducted to estimate the financial burden from the governmental perspective over a five-year period. Results Compared to BSC, A+B provided a better health benefit with 0.8309 QALY gained at an incremental lifetime cost of $45,357. The ICER was $54,589 per QALY gained. The result was sensitive to the hazard ratios for the overall survival and progression-free survival of A+B. At the current Thai willingness-to-pay (WTP) threshold of $4,678 per QALY gained, the ICER of A+B remained above the threshold. The projected budgetary requirements for implementing A+B in the respective first and fifth years would range from 8.2 to 27.9 million USD. Conclusion Although A+B yielded the highest clinical benefit compared with BSC for the treatment of uHCC patients, A+B is not cost-effective in Thailand at the current price and poses budgetary challenges.
Argument Labeling of Explicit Discourse Relations using LSTM Neural Networks

Argument labeling of explicit discourse relations is a challenging task. The state of the art systems achieve slightly above 55% F-measure but require hand-crafted features. In this paper, we propose a Long Short Term Memory (LSTM) based model for argument labeling. We experimented with multiple configurations of our model. Using the PDTB dataset, our best model achieved an F1 measure of 23.05% without any feature engineering. This is significantly higher than the 20.52% achieved by the state of the art RNN approach, but significantly lower than the feature based state of the art systems. On the other hand, because our approach learns only from the raw dataset, it is more widely applicable to multiple textual genres and languages.
Breaking down the cocktail party: Capturing and isolating sources in a soundscape

Spatial scene capture and reproduction requires extracting directional information from captured signals. Our previous work focused on directional coding of a sound scene using a single microphone array. In this paper, we investigate the benefits of using multiple microphone arrays, and extend our previous method by allowing arrays to cooperate during spatial feature extraction. We can thus render the sound scene using both direction and distance information and selectively reproduce specific “spots” of the captured sound scene.
S3 guidelines for intensive care in cardiac surgery patients: hemodynamic monitoring and cardiocirculary system

Hemodynamic monitoring and adequate volume-therapy, as well as the treatment with positive inotropic drugs and vasopressors are the basic principles of the postoperative intensive care treatment of patient after cardiothoracic surgery. The goal of these S3 guidelines is to evaluate the recommendations in regard to evidence based medicine and to define therapy goals for monitoring and therapy. In context with the clinical situation the evaluation of the different hemodynamic parameters allows the development of a therapeutic concept and the definition of goal criteria to evaluate the effect of treatment. Up to now there are only guidelines for subareas of postoperative treatment of cardiothoracic surgical patients, like the use of a pulmonary artery catheter or the transesophageal echocardiography. The German Society for Thoracic and Cardiovascular Surgery (Deutsche Gesellschaft für Thorax-, Herz- und Gefäßchirurgie, DGTHG) and the German Society for Anaesthesiology and Intensive Care Medicine (Deutsche Gesellschaft für Anästhesiologie und lntensivmedizin, DGAI) made an approach to ensure and improve the quality of the postoperative intensive care medicine after cardiothoracic surgery by the development of S3 consensus-based treatment guidelines. Goal of this guideline is to assess the available monitoring methods with regard to indication, procedures, predication, limits, contraindications and risks for use. The differentiated therapy of volume-replacement, positive inotropic support and vasoactive drugs, the therapy with vasodilatators, inodilatators and calcium sensitizers and the use of intra-aortic balloon pumps will also be addressed. The guideline has been developed following the recommendations for the development of guidelines by the Association of the Scientific Medical Societies in Germany (AWMF). The presented key messages of the guidelines were approved after two consensus meetings under the moderation of the Association of the Scientific Medical Societies in Germany (AWMF).
Mottle: Accurate pairwise substitution distance at high divergence through the exploitation of short-read mappers and gradient descent

Current tools for estimating the substitution distance between two related sequences struggle to remain accurate at a high divergence. Difficulties at distant homologies, such as false seeding and over-alignment, create a high barrier for the development of a stable estimator. This is especially true for viral genomes, which carry a high rate of mutation, small size, and sparse taxonomy. Developing an accurate substitution distance measure would help to elucidate the relationship between highly divergent sequences, interrogate their evolutionary history, and better facilitate the discovery of new viral genomes. To tackle these problems, we propose an approach that uses short-read mappers to create whole-genome maps, and gradient descent to isolate the homologous fraction and calculate the final distance value. We implement this approach as Mottle. With the use of simulated and biological sequences, Mottle was able to remain stable to 0.66–0.96 substitutions per base pair and identify viral outgroup genomes with 95% accuracy at the family-order level. Our results indicate that Mottle performs as well as existing programs in identifying taxonomic relationships, with more accurate numerical estimation of genomic distance over greater divergences. By contrast, one limitation is a reduced numerical accuracy at low divergences, and on genomes where insertions and deletions are uncommon, when compared to alternative approaches. We propose that Mottle may therefore be of particular interest in the study of viruses, viral relationships, and notably for viral discovery platforms, helping in benchmarking of homology search tools and defining the limits of taxonomic classification methods. The code for Mottle is available at https://github.com/tphoward/Mottle_Repo.
A Voice in the Room: The Function of State Legislative Bans on Sexual Orientation Change Efforts for Minors

Throughout the history of the mental health profession, many psychotherapists have asserted that homosexuality is a mental condition or defect that may be corrected through treatment. Homosexuality was not officially declassified as a mental illness until 1973, and it was not until recently that mainstream mental health organizations renounced the claim that therapy can alter sexual orientation. Sexual orientation change efforts (SOCE) involve various types of psychotherapy, from the familiar and seemingly benign talk therapy to forms of behavioral therapy that include “masturbatory reconditioning, rest, visits to prostitutes[,] excessive bicycle riding,” and even physical abuse. SOCE are now widely regarded by mainstream mental health practitioners as unscientific, ineffective, and mentally and emotionally harmful. Nevertheless, due to persistent societal disapproval of homosexuality, some mental health providers continue to engage in SOCE, often causing their patients to experience shame and anxiety well into adulthood.
Use Case Based Requirements Verification - Verifying the Consistency between Use Cases and Assertions

Use cases and operations are complementary requirements artefacts. A use case refers to operations and imposes their sequencing. Use cases templates usually include assertions such as preconditions, postconditions and invariants. Similarly operations are specified using contracts consisting in preconditions and postconditions. In this paper, we present an approach aiming at checking the consistency of each description against the other. We attempt to answer questions such as the following. Is the use case postcondition guaranteed by the operations ? Are all operations possible according to their preconditions ? We provide answers to these questions by deriving state predicates corresponding to each step in a use case, and by showing the satisfaction of assertions according to these predicates.
Oversampling Increases the Pre-Log of Noncoherent Rayleigh Fading Channels

We analyze the capacity of a continuous-time, time-selective, Rayleigh block-fading channel in the high signal-to-noise ratio (SNR) regime. The fading process is assumed stationary within each block and to change independently from block to block; furthermore, its realizations are not known a priori to the transmitter and the receiver (noncoherent setting). A common approach to analyzing the capacity of this channel is to assume that the receiver performs matched filtering followed by sampling at symbol rate (symbol matched filtering). This yields a discrete-time channel in which each transmitted symbol corresponds to one output sample. Liang & Veeravalli (2004) showed that the capacity of this discrete-time channel grows logarithmically with the SNR, with a capacity pre-log equal to 1-Q/N. Here, N is the number of symbols transmitted within one fading block, and Q is the rank of the covariance matrix of the discrete-time channel gains within each fading block. In this paper, we show that symbol matched filtering is not a capacity-achieving strategy for the underlying continuous-time channel. Specifically, we analyze the capacity pre-log of the discrete-time channel obtained by oversampling the continuous-time channel output, i.e., by sampling it faster than at symbol rate. We prove that by oversampling by a factor two one gets a capacity pre-log that is at least as large as 1-1/N. Since the capacity pre-log corresponding to symbol-rate sampling is 1-Q/N, our result implies indeed that symbol matched filtering is not capacity achieving at high SNR.