Miracle-dz/UniFAR-FTUs huggingface dataset:
DMSO_A_267948 3487..3495

1Department of Cardiology ICoronary and Peripheral Vascular Disease, Heart Failure Medicine, University Hospital Muenster, Cardiol, Muenster 48149, Germany; 2Department of Cardiology, Sector Preventive Medicine, Health Promotion, Faculty of Health, School of Medicine, University Witten/Herdecke, Hagen 58095, Germany; 3Department of Physiotherapy, Chair of Physiotherapy, School of Health Sciences, Medical University of Silesia, Katowice, Poland; 4Department of Medicine B, Gastroenterology and Hepatology, University Hospital Muenster, Muenster 48149, Germany; 5Department of Medicine D, Division of General Internal Medicine, Nephrology and Rheumatology, University Hospital of Muenster, Muenster 48149, Germany Introduction: Increase in the prevalence of metabolic syndrome (MetS) has become a worldwide major health problem. So far, there are limited data about the impact of occupation types and the development of metabolic risks in females. This study aimed to compare the metabolic risk profiles and in two extremely different female occupational groups: police officers (PO) and office workers (OW). Methods: The prospective study included a total number of 97 female subjects (37 POs and 60 OWs) from Germany. Anthropometric characteristics, metabolic risk parameters as well as laboratory parameters were taken. The diagnosis of MetS was based on the criteria of the International Diabetes Federation (IDF). Results: Female OWs presented a high prevalence of obesity, shown in average abdominal waist circumference (85.3 ± 14.5 cm) above the threshold of ≥80 cm recommended by the IDF to define abdominal obesity. Sixty percent of OWs versus 25% of POs had an abnormal abdominal waist circumference. Concerning other metabolic risk factors (HDL, triglycerides, body mass index, blood pressure) no significant differences were found, but a tendency toward a higher prevalence of abnormal values is presented in OWs than POs. MetS was detected in almost 8% of OWs as compared with 5% in POs (p = 0.705). Conclusion: In an international comparison, German female POs showed one of the lowest prevalence of MetS, whereas the prevalence in OWs is equal to results in other countries. In conclusion, especially the occupational type of female OWs presented elevated factors, that are associated with increased metabolic risk. There is a relevant need for further prospective studies with larger sample sizes in female workers to determine the influence between occupational type and metabolic system.
Assessing the Outcomes of Coronary Artery Bypass Graft Surgery: How Many Risk Factors Are Enough? fn1fn2

Objectives. We sought to determine whether more comprehensive risk-adjustment models have a significant impact on hospital risk-adjusted mortality rates after coronary artery bypass graft surgery (CABG) in Ontario, Canada. Background. The Working Group Panel on the Collaborative CABG Database Project has categorized 44 clinical variables into 7 core, 13 level 1 and 24 level 2 variables, to reflect their relative importance in determining short-term mortality after CABG. Methods. Using clinical data for all 5,517 patients undergoing isolated CABG in Ontario in 1993, we developed 12 increasingly comprehensive risk-adjustment models using logistic regression analysis of 6 of the Panel’s core variables and 6 of the Panel’s level 1 variables. We studied how the risk-adjusted mortality rates of the nine cardiac surgery hospitals in Ontario changed as more variables were included in these models. Results. Incorporating six of the core variables in a riskadjustment model led to a model with an area under the receiver operating characteristic (ROC) curve of 0.77. The ROC curve area slightly improved to 0.79 with the inclusion of six additional level 1 variables (p 5 0.063). Hospital risk-adjusted mortality rates and relative rankings stabilized after adjusting for six core variables. Adding an additional six level 1 variables to a risk-adjustment model had minimal impact on overall results. Conclusions. A small number of core variables appear to be sufficient for fairly comparing risk-adjusted mortality rates after CABG across hospitals in Ontario. For efficient interprovider comparisons, risk-adjustment models for CABG could be simplified so that only essential variables are included in these models. (J Am Coll Cardiol 1997;30:1317–23) ©1997 by the American College of Cardiology
New approach in Mahler's method.

One of the most important motivations to write this paper originates the paper [3] by Loxton and van der Poorten in which they study algebraic independence of the values of Mahler functions. The first sentence in the proof of Lemma 5 in [3] is not clear. In this paper we will prove a theorem which includes the theorem for functions of one variable in [3] by Nesterenko's method in [6]. In [6] Nesterenko found an algebraic independence measure of the values of Mahler functions whose algebraic independence has been already known. Here we shall show that his method is applicable even to the algebraic independence of the values of Mahler functions of more general type.
Molecular Mechanisms Underlying the Positive Stringent Response of the Bacillus subtilis ilv-leu Operon, Involved in the Biosynthesis of Branched-Chain Amino Acids (cid:1)

Branched-chain amino acids are the most abundant amino acids in proteins. The Bacillus subtilis ilv-leu operon is involved in the biosynthesis of branched-chain amino acids. This operon exhibits a RelA-dependent positive stringent response to amino acid starvation. We investigated this positive stringent response upon lysine starvation as well as decoyinine treatment. Deletion analysis involving various lacZ fusions revealed two molecular mechanisms underlying the positive stringent response of ilv-leu , i.e., CodY-dependent and -inde-pendent mechanisms. The former is most likely triggered by the decrease in the in vivo concentration of GTP upon lysine starvation, GTP being a corepressor of the CodY protein. So, the GTP decrease derepressed ilv-leu expression through detachment of the CodY protein from its cis elements upstream of the ilv-leu promoter. By means of base substitution and in vitro transcription analyses, the latter (CodY-independent) mechanism was found to comprise the modulation of the transcription initiation frequency, which likely depends on ﬂuctuation of the in vivo RNA polymerase substrate concentrations after stringent treatment, and to involve at least the base species of adenine at the 5 (cid:1) end of the ilv-leu transcript. As discussed, this mechanism is presumably distinct from that for B. subtilis rrn operons, which involves changes in the in vivo concentration of the
BLCTT_A_262592 1..5

Seattle Cancer Care Alliance, Fred Hutchinson Cancer Research Center, Seattle, WA, USA; Division of Hematological Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH, USA; Division of Hematology and Medical Oncology, New York Presbyterian & Weill Cornell, New York, NY, USA; Norris Cotton Cancer Center, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA; Department of Hematologic Oncology and Blood Disorders, Levine Cancer Institute, Charlotte, NC, USA; Novant Health Cancer Institute, Charlotte, NC 28204, USA; Lowell General Hospital, Tufts Medical Center, Boston, MA, USA; Center for Blood Disorders and Stem Cell Transplantation, Swedish Cancer Institute, Seattle, WA, USA; Division of Hematologic Malignancies and Cellular Therapy, Duke University, Durham, NC, USA; Lombardi Comprehensive Cancer Center, Georgetown University Hospital, Washington, DC, USA; Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, NY, USA; Division of Hematology/Oncology, SUNY Upstate Medical University, Syracuse, NY, USA; Division of Hematology & Oncology, Medical College of Wisconsin, Milwaukee, WI, USA; John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, NJ, USA; Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA; Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY, USA; University of Pittsburgh Medical Center, Pittsburgh, PA, USA; Peter McCallum Cancer Centre, University of Melbourne, East Melbourne, VI, Australia Introduction: Recent randomized trials have demonstrated the efficacy of ibrutinib-based therapy in the treatment of patients with CLL. In Alliance A041202, a higher than expected number of unexplained deaths were reported with front-line ibrutinib in a patient population aged at least 65 years compared to ECOG 1912, which included patients up to 70 years of age. Methods: Therefore, we conducted a retrospective analysis to investigate whether ibrutinib was associated with a greater mortality in older patients outside of a clinical trial setting. This multicenter analysis was performed by investigators at 20 academic and community practices. Results: Amongst the 391 patients included, there was no correlation between age and response rate, PFS, or OS. However, there was a trend to higher rate of deaths in patients >65years-old (8.7% vs 3.8%, p=0.097), with an increased number of early deaths (13 vs 4, p=0.3). Conclusion: These data suggest greater intolerance, and possibly mortality, with ibrutinib in an older population. Patients should be educated regarding the potential complications related to ibrutinib and symptoms of concern to report.
CMAR_A_313771 4955..4966

1School of Public Health, Anhui Medical University, Hefei, Anhui, People’s Republic of China; 2School of Health Service Management, Anhui Medical University, Hefei, Anhui, People’s Republic of China Background: Early prevention and diagnosis are key to reducing the huge burden of gastric cancer (GC). Nearly half of the population worldwide are suffering from some form of digestive tract conditions (symptoms/diagnoses, DTCs) but their relations with GC are not well understood. We aim to explore the relationships (especially dose–effect relationships) between GC and DTCs. Methods: This study used data from a community-based case–control study in Anhui, China during 2016–2019 and performed multivariate conditional logistic regression modeling of the associations between GC and DTCs. Results: A total of 2255 participants (451 cases and 1804 controls) completed the study. Statistically significant relations (P<0.05) were found between GC and the presence of gastroesophageal reflux [odds ratio (OR)=1.41], odynophagia (OR=1.87), stomach discomfort (OR=1.86), poor appetite (OR=2.01) and Helicobacter pylori (H. pylori) infection (OR=4.39). When the DTCs were divided into duration grades, all these ORs presented an increasing trend (P<0.05), being 1.89 to 2.45 for gastroesophageal reflux, 1.63 to 3.78 for stomach discomfort, 2.36 to 5.29 for poor appetite, and 3.95 to 10.03 for H. pylori infection. When the DTCs were divided into severity grades, the ORs also witnessed an increasing trend (P<0.05), being 1.69 to 2.52 for gastroesophageal reflux, 2.44 to 3.56 for stomach discomfort, and 2.22 to 2.75 for poor appetite. When the DTCs were divided into durationseverity grades, the ORs displayed a much steeper increasing trend, being 0.49 to 4.96 for gastroesophageal reflux, 1.50 to 6.33 for odynophagia, 0.47 to 3.32 for stomach discomfort, and 0.40 to 10.47 for poor appetite. In contrast, the ORs for the lower DTCs were generally tested without statistical significance. Conclusion: The study revealed consistent dose–effect associations between GC and duration of gastroesophageal reflux, stomach discomfort, poor appetite, and H. pylori infection; severity of gastroesophageal reflux, stomach discomfort and poor appetite; and durationseverity of gastroesophageal reflux, odynophagia, stomach discomfort and poor appetite. These should inform future prevention, diagnosis and further research in patients with GC.
NSS_A_345143 153..163

1Department of Pediatrics, University of Toronto, Toronto, Canada; 2The Hospital for Sick Children, Toronto, Canada; 3Department of Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Canada; 4The Ottawa Hospital Research Institute, Ottawa, Canada; 5UBC, Faculty of Medicine, Vancouver, Canada; 6RCSI University of Medicine and Health Sciences, Dublin, Ireland; 7University Health Network, 8Department of Medicine, University of Toronto, Toronto, Canada; 9Sleep Research laboratory, KITE-UHN
Moist-Heat Resistance, Spore Aging, and Superdormancy in Clostridium difﬁcile (cid:1) †

Clostridium difﬁcile spores can survive extended heating at 71°C (160°F), a minimum temperature commonly recommended for adequate cooking of meats. To determine the extent to which higher temperatures would be more effective at killing C. difﬁcile , we quantiﬁed ( D values) the effect of moist heat at 85°C (145°F, for 0 to 30 min) on C. difﬁcile spores and compared it to the effects at 71 and 63°C. Fresh (1-week-old) and aged ( > 20-week-old) C. difﬁcile spores from food and food animals were tested in multiple experiments. Heating at 85°C markedly reduced spore recovery in all experiments (5 to 6 log 10 within 15 min of heating; P < 0.001), regardless of spore age. In ground beef, the inhibitory effect of 85°C was also reproducible ( P < 0.001), but heating at 96°C reduced 6 log 10 within 1 to 2 min. Mechanistically, optical density and enumeration experiments indicated that 85°C inhibits cell division but not germination, but the inhibitory effect was reversible in some spores. Heating at 63°C reduced counts for fresh spores (1 log 10 , 30 min; P < 0.04) but increased counts of 20-week-old spores by 30% (15 min; P < 0.02), indicating that sublethal heat treatment reactivates superdormant baths the two tested 63 which encompass the thermal spectrum of widely food safety household minimal internal cooking of on pilot trials, timing 10 to 15 s the PCR tubes were immersed the bath, when the temperature inside tested tubes reached target temperatures. Then, at speciﬁc time intervals (0, 15, and 30 min for 63°C and 0, 3, 6, 9, 12, 15, and 30 min for 85°C), aliquots were removed, in icy water, and enumerated using the spread-plating method on blood agar. Colonies were plated in duplicate and counted after 72 h of anaerobic incubation at 37°C. To conﬁrm that survivor colonies corresponded to the strains tested, PCR ribotyping used genotypes the inoculum and heated recovered were identical. The D values (decimal reduction times; i.e., time needed to inhibit 90% of spores) were determined using at least two linear equation ﬁts of the inhibition curves excluding the graph shoulders, i.e., the and ﬁnal time points Because precedent enumeration studies of C. difﬁcile in feces indicate that spore recoverability during storage decreases over time (43), we also determined if refrigeration (4 (cid:3) 2°C) would reduce the recoverability of heated and nonheated spores over time. Thus, replicate aliquots of all nonheated strains and replicate aliquots of heated PCR ribotype 078 strain (85°C) at multiple time points (3, 6, 9, 12 and 15 min) were enumerated after 14 and 18 days of refrigeration. Paired analysis and D values from PCR ribotype 078 aliquots used to variability.
Functional Analysis of Maize RAD51 in Meiosis and DSBs Repair

* Department of Genetics, Development and Cell Biology, Iowa State University, Ames, IA 50011 † Interdepartmental Genetics Program, Iowa State University, Ames, IA 50011 ‡ Department of Molecular and Cell Biology, University of California, Berkeley, California, 94720-3200 § Department of Biological Sciences, Illinois State University, Normal, IL 61790 ** Pioneer Hi-Bred Intl. Inc., Johnston, Iowa 50131 †† Department of Agronomy, Iowa State University, Ames, Iowa 50011 ‡‡ Center for Plant Genomics, Iowa State Unversity, Ames, Iowa 50011
COPD_A_218785 479..486

Okan University, Okan University Chest Diseases, İçmeler, Turkey Purpose: Emphysema is a progressive and irreversible disease, proceeding with the decrease in elastic recoil which is connected to tissue damage caused by chronic inflammation. Lung volume reduction coil (LVRC) method in patients with an advanced level of emphysema and irresponsive to medical treatment is shown to provide increase in lung volumes and exercise capacity, decrease in dyspnea, and increase in quality of life. The purpose of this study is to reveal that LVRC treatment is also efficient in severe COPD patients with hypercapnic respiratory failure. Patients and Methods: Eleven cases with severe COPD and emphysema were included in the study. LVRC treatment method was applied in upper lobes of both lungs in patients with severe COPD (FEV1 < %45) and Type-2 respiratory insufficiency (PCO2 55–80 mmHg) who were having medical treatment and CPAP treatment. The patients were followed up for a period of twelve months using arterial blood gas analysis. Results: Beginning with the first month of the LVRC treatment, PCO2 levels were found to be significantly decreased in all patients using arterial blood gas analysis. Conclusion: LVRC method can provide physiological and functional recovery and progress in quality of life in severe COPD cases. It is demonstrated that LVRC treatment caused significant decreases in carbon dioxide levels as well as causing improvement in life quality and respiratory function tests in the patients with hypercapnic respiratory failure.
CSF Tau Protein in Alzheimer’s Disease and other Neurological and Psychiatric Diseases

Total tau (T-tau) in the Cerebrospinal Fluid (CSF) is among the most reliable markers for the diagnosis of Alzheimer’s disease (AD). However, the high inter-center variation in biomarker concentrations points to the need for setting up specific diagnostic cut-offs for each population. We analyzed the level of T-tau in the CSF of 490 patients affected by AD or other neurological and psychiatric diseases, among the Israeli population. The T-tau levels were significantly higher in the AD group than in the other non-AD diseases, particularly in the other common dementia Fronto Temporal Dementia (FTD), as well as in psychiatric diseases. Receiver-Operating-Characteristic (ROC) analysis provided a ≥240 pg/ml cut-off for discrimination between AD and other non-AD diseases {sensitivity 68%, specificity 60%, negative-PV (predictive-value) 84.4%}, and psychiatric diseases (60%, 80%, positive-PV 93.4%), and from FTD (60%, 61.1%, positive-PV 85.8%), respectively. In spite of low PVs, T-tau levels in the AD patients were also higher than in vascular-dementia, Parkinson’s-disease, epilepsy, with similar trends relative to multiple-system-atrophy, dementia with Lewy-body-disease, autoimmune and other degenerative diseases, while comparable with metabolic and acute neurological diseases. Our previously reported ≥1,000 pg/ml cut-off for Creutzfeldt–Jakob Disease (CJD) diagnosis allows discrimination from AD (sensitivity 75%, specificity 92.7%, PPV 86.56% NPV 85.8%). An inverse correlation was noticed between CSF T-tau levels and Mini-Mental-State-Examination (MMSE) scores in AD and in VD. Using ≥240 pg/ml as a cut-off we showed here that the T-tau level in CSF could be an indicator for differentiation of AD from psychiatric diseases and from FTD in our population. While also informative at ≥1000 pg/ml for CJD, the T-tau level was less informative for discrimination of AD from other neurological diseases. Combining the T-tau level in the CSF with other parameters (additional CSF markers, as well as genetic and clinical, including imaging parameters) may provide a stronger indication for AD. atrophy, cerebellar atrophy, Shy Drager, neuro-axonal sclerotic encephalopaty, CNS degeneration, prog bulbar palsy) (n=8)}, epilepsy (n=16), metabolic diseases {hepatic/pancreatic encephalopathies, mitochondrial encephalomyopathy, lactic acidosis autoimmune diseases (vasculitis, mild cognitive polyneuropathy, ataxia
Do current definitions and methods promote the general 2 application of functional traits and functional diversity?

19 The use of functional traits has increased exponentially in ecology, particularly in 20 attempting to explain ecosystem functioning. This popularity has led to many 21 proposed definitions of functional traits, which in turn has informed recommendations 22 about how to gather, summarize, and analyze trait data. In this paper, we revisit the 23 definition of the functional trait from the perspective of physiological, community and 24 ecosystem ecologists, and reason towards a broad, unrestrictive, and applicable 25 definition. We then demonstrate how a popular technique, ordination, which is used to 26 collapse multivariate trait data into orthogonal axes, undermines this definition and 27 the primary benefit of functional traits. We outline the conceptual pitfalls associated 28 with ordination, and make specific suggestions about alternative methods that 29 progress functional traits as generalizable proxies for how organisms affect ecosystem 30 processes. We hope these suggestions will improve our ability to move towards an 31 ecological synthesis using a trait-based approach. 32
Sex differences in the inhibition of (cid:1) -tocopherol metabolism by a single dose of dietary sesame oil in healthy subjects 1–3

Background: (cid:1) -Tocopherol has unique properties that may be beneficial in sustaining optimal human health, but hepatic vitamin E metabolism enhances (cid:1) -tocopherol turnover. Objective: Our aim was to determine the extent to which dietary sesame lignans alter human (cid:2) - and (cid:1) -tocopherol metabolism and elimination as carboxyethyl hydroxychromanols (CEHCs). Design: Healthy participants ( n (cid:1) 5 women and 5 men) in a ran-domized, crossover study (with 4-wk washout) consumed muffins prepared with either corn oil or unrefined sesame oil (sesamin, 94 mg; sesamolin, 42 mg), along with a capsule containing a 1:1 molar ratio of deuterium-labeled d 6 - (cid:2) - and d 2 - (cid:1) -tocopherol acetates ( (cid:2) 50 mg each). Plasma and urine were collected up to 72 h; unlabeled and labeled tocopherol and CEHC concentrations were determined by liquid chromatography–mass spectrometry. Results: Sesame oil muffin consumption in men, but not in women, decreased( P (cid:3) 0.05)areasunderplasmad 2 - (cid:1) -CEHCconcentration-time curves (area under the curve) and maximum concentrations. However,inbothsexesurinaryd 2 - (cid:1) -CEHCsweredecreasedfor24h following sesame oil muffin consumption. Conclusions: In humans, (cid:1) -tocopherol metabolism can be inhibited by the simultaneous consumption of (cid:1) -tocopherol and sesame lignans. The observed differences between men and women with re-specttovitaminEmetabolismwarrantfurtherinvestigation. (cid:1) -tocopherol concentrations, a randomized, crossover study was carried out in both women and men. The participants consumed deuterium-labeled (cid:2) - and (cid:1) -tocopheryl acetates along with a breakfast containing either sesame or corn oil muffins; after a 4-wk washout, the subjects repeated the study with the opposite muffin.