Miracle-dz/UniFAR-FTUs huggingface dataset:
Global X-Ray Properties of the Vela and Puppis A Supernova Remnants

The Vela and Puppis A supernova remnants (SNRs) comprise a large emission region of ∼8° diameter in the soft X-ray sky. The HaloSat CubeSat mission provides the first soft X-ray (0.4–7 keV) observation of the entire Vela SNR and Puppis A SNR region with a single pointing and moderate spectral resolution. HaloSat observations of the Vela SNR are best fit with a two-temperature thermal plasma model consisting of a cooler component with keV in collisional ionization equilibrium and a hotter component with keV in nonequilibrium ionization. Observations of the Puppis A SNR are best fit with a single-component plane-parallel shocked plasma model with keV in nonequilibrium ionization. For the first time, we find the total X-ray luminosities of both components of the Vela SNR spectrum in the 0.5–7 keV energy band to be erg s−1 for the cooler component and erg s−1 for the hotter component. We find the total X-ray luminosities of the Vela and Puppis A SNRs to be erg s−1 and erg s−1.
Fair Policy Targeting

One of the major concerns of targeting interventions on individuals in social welfare programs is discrimination: individualized treatments may induce disparities on sensitive attributes such as age, gender, or race. This paper addresses the question of the design of fair and efficient treatment allocation rules. We adopt the non-maleficence perspective of "first do no harm": we propose to select the fairest allocation within the Pareto frontier. We provide envy-freeness justifications to novel counterfactual notions of fairness. We discuss easy-to-implement estimators of the policy function, by casting the optimization into a mixed-integer linear program formulation. We derive regret bounds on the unfairness of the estimated policy function, and small sample guarantees on the Pareto frontier. Finally, we illustrate our method using an application from education economics.
Larval Herring (Clupea harengus) Dispersion, Growth, and Survival in the St, Lawrence Estuary: Match/Mismatch or Membership/Vagrancy?

The relative success of the 1985 spring and fall cohorts of Atlantic herring (Clupea harengus) in the St. Lawrence estuary was studied in relation to food availability (match/mismatch hypothesis) and hydrography (member/vagrant hypothesis). The development of the spring cohort (early June) matched remarkably well the development of suitable prey and larval abundance within the estuary decreased slowly (7.8%∙d−1). The fall cohort (mid-September) hatched in a period of low food availability and dwindled rapidly (28.9%∙d−1). The initial growth of both cohorts appeared limited by food. The stratification front limiting seaward drift was strong in the spring (0–80 j∙m−3) and weak in the fall (0–20 J∙m−3), suggesting that advection out of the estuary could also have contributed to the observed differences in the fate of the two cohorts. We conclude from this case study that spawning times and locations may have evolved to favor the initial cohesion of larval fish cohorts by limiting dispersion and that both tra.
Evaluating epidemic forecasts in an interval format

For practical reasons, many forecasts of case, hospitalization, and death counts in the context of the current Coronavirus Disease 2019 (COVID-19) pandemic are issued in the form of central predictive intervals at various levels. This is also the case for the forecasts collected in the COVID-19 Forecast Hub (https://covid19forecasthub.org/). Forecast evaluation metrics like the logarithmic score, which has been applied in several infectious disease forecasting challenges, are then not available as they require full predictive distributions. This article provides an overview of how established methods for the evaluation of quantile and interval forecasts can be applied to epidemic forecasts in this format. Specifically, we discuss the computation and interpretation of the weighted interval score, which is a proper score that approximates the continuous ranked probability score. It can be interpreted as a generalization of the absolute error to probabilistic forecasts and allows for a decomposition into a measure of sharpness and penalties for over- and underprediction.
Higgs chameleon

The existing constraints from particle colliders reveal a suspicious but nonlethal meta-stability for our current electroweak vacuum of Higgs potential in the standard model of particle physics, which is, however, disfavored in the early Universe if the inflationary Hubble scale is larger than the instability scale when Higgs quartic self-coupling runs into negative value. Alternative to previous trials of acquiring a positive effective mass-squared from Higgs quadratic couplings to Ricci scalar or inflaton field, we propose a third approach to stabilize the Higgs potential in the early Universe by regarding Higgs as chameleon coupled to inflaton alone without conflicting to the present constraints on either Higgs or chameleon.
On the spider parasitoids Polysphincta longa Kasparyan and P. boops Tschek (Hymenoptera, Ichneumonidae, Pimplinae), with the first host records of P. longa

The rarely recorded Polysphincta longa is probably widely overlooked in Europe as a result of confusion with the morphologically similar P. boops. Characters for the separation of these species are given, and host and distribution records, largely based on recent fieldwork, are presented. Araneus angulatus is shown to be the hitherto unknown host of P. longa, while all rearing records for P. boops are from Araniella species. P. longa is reported as new to the fauna of the United Kingdom and P. boops as new to Estonia.
Expression of a moderately anionic peroxidase is induced by aluminum treatment in tobacco cells: Possible involvement of peroxidase isozymes in aluminum ion stress

To clarify the mechanism of aluminum (Al) toxicity and Al tolerance, we isolated a new clone (pAL201) from a tobacco cDNA library. Northern blot hybridization analysis indicated that the expression of pAL201 is induced by Al treatment and phosphate (P i ) starvation. The complete cDNA sequence suggested that this clone encodes a moderately anionic peroxidase (EC 1.11.1.7). Analysis by isoelectric focussing indicated that a moderately anionic peroxidase (approximately pI 6.7) and two cationic peroxidases (pI 9.2 and 9.7) in the soluble fraction are activated by Al treatment and P i starvation, while two moderately anionic isozymes are repressed by these stresses. We suppose that Al ion stress can control the activity of some peroxidase isozymes, one of which is probably induced by enhanced gene expression of pAL201. There is a possibility that some of these isozymes have some functions in Al ion stress.
Stein’s method of exchangeable pairs in multivariate functional approximations

In this paper we develop a framework for multivariate functional approximation by a suitable Gaussian process via an exchangeable pairs coupling that satisfies a suitable approximate linear regression property, thereby building on work by Barbour (1990) and Kasprzak (2020). We demonstrate the applicability of our results by applying it to joint subgraph counts in an Erdős-Renyi random graph model on the one hand and to vectors of weighted, degenerate $U$-processes on the other hand. As a concrete instance of the latter class of examples, we provide a bound for the functional approximation of a vector of success runs of different lengths by a suitable Gaussian process which, even in the situation of just a single run, would be outside the scope of the existing theory.
On the origin of the weak equivalence principle in a theory of emergent quantum mechanics

We argue that in a framework for emergent quantum mechanics, the weak equivalence principle is a consequence of concentration of measure in large dimensional spaces of $1$-Lipshitz functions. Furthermore, as a consequence of the emergent framework and the properties that we assume for the fundamental dynamics, it is argued that gravity must be a classical, emergent interaction.
Minimally Invasive Distal Pancreatectomy Is Associated with Decreased Postoperative Neutrophil to Lymphocyte Ratio

Purpose: The neutrophil-to-lymphocyte ratio (NLR) is a marker of inflammation that has been investigated as a prognostic factor in many diseases. We hypothesized that NLR would be lower in patients undergoing minimally invasive distal pancreatectomy (MIDP). Methods: Using a prospective database, we identified patients who underwent open or minimally invasive (laparoscopic/robotic) distal pancreatectomy and splenectomy from 2006 to 2018. Patients were grouped according to their type of surgery and matched by age, gender, and benign or malignant pathology. The NLR was calculated from a complete blood count with differential on the second postoperative day. Statistical calculations were performed in Stata (v13.0). Results: A total of 106 patients were included, with 53 MIDP and 53 open cases. MIDP was associated with a significantly lower postoperative NLR than open surgery (13.3 vs. 17.2, p = 0.01). NLR did not vary significantly between patients who developed complications and those who did not (15.4 vs. 15.3, p = 0.95). Patients undergoing MIDP had decreased length of postoperative hospital stay (4 days vs. 5 days, p = 0.003). Multivariable linear regression failed to find a significant decrease in NLR with the use of laparoscopy (p = 0.14) when accounting for age, body mass index, surgical blood loss, pathology, and operative time as covariates. Conclusion: The NLR is significantly decreased when performing MIDP versus open distal pancreatectomy, but correlation with clinical outcomes has yet to be proven.
Diet of sardine Sardinops sagax in the southern Benguela upwelling ecosystem

The diet of sardine Sardinops sagax in the southern Benguela was investigated by microscopic examination of stomach contents. The relative dietary importance of prey size and prey type was assessed by calculating the carbon content of prey items. Sardine is an omnivorous clupeoid, ingesting both phytoplankton and zooplankton, with the relative importance of these two food types varying both spatially and temporally. Stomach contents were numerically dominated by small prey items, principally dinoflagellates, followed by crustacean eggs, cyclopoid copepods, calanoid copepods and diatoms. Virtually all prey items ingested by sardine were <1.2 mm maximum dimension, the particle size below which sardine only filter-feed. Despite the numerical dominance by phytoplankton, zooplankton contributed the major portion to sardine dietary carbon, small calanoid and cyclopoid copepods, anchovy eggs and crustacean eggs being the primary prey types. These results indicate that, like anchovy Engraulis capensis, sardine in the southern Benguela are primarily zoophagous, and contrast with earlier dietary studies on sardine in the region. However, the two species appear to partition their prey on the basis of size; sardine consume small zooplankton, whereas anchovy consume large zooplankton. This difference has been observed in other upwelling ecosystems where the two genera co-exist and is likely to contribute to the regime shifts observed between sardine and anchovy.
The Prevalence of Dental Caries in Primary Dentition in 3- to 5-Year-Old Preschool Children in Northern China

Objectives To investigate the prevalence and factors promoting caries in primary dentition of 3-5-year-old children in Northeast China. Materials and Methods Data of 1,229 children aged 3 to 5 years were randomly selected. The caries prevalence and other indicators were assessed, and the results analyzed by SPSS. A questionnaire was also given to the children's guardians to ascertain the potential risk factors associated with caries. Results The decayed, missing, and filled teeth (dmft) index in children aged 3, 4, and 5 years old was 3.17, 5.13, and 6.07, respectively, while the caries prevalence rate was 62.16%, 75.89%, and 87.28% accordingly. The incidence of caries among rural children was higher than that in urban areas. Regarding oral health awareness, it was found that parents in urban areas had more accurate perceptions of oral health problems. It was also noted that the children's brushing habits were worrying. Family economic and medical resources are not the main causes of serious dental caries in rural areas. Conclusions The oral health status of children aged 3-5 years is not optimistic. Many parents have a low awareness of oral health. Strengthening the promotion of oral health knowledge is an effective way to change the situation.
The Effect of Different Treatment Regimens and Multiple Risk Factors on Adverse Pregnancy Outcomes among Syphilis-Seropositive Women in Guangzhou: A Retrospective Cohort Study

Background To eliminate mother-to-child transmission of syphilis, the Chinese government recommends a treatment regimen that slightly differs from the World Health Organization- (WHO-) recommended treatment. However, little is known about their difference in efficacy. This study is aimed at comparing the effect of China-recommended and WHO-recommend treatment regimens on adverse pregnancy outcomes (APOs) and at examining associated risk factors of APOs among syphilis-seropositive women. Methods Using the syphilis registry data, we retrospectively collected data from 4488 syphilis-infected pregnant women in Guangzhou during 2011-2018. Multivariate analyses were used to investigate the association between treatment regimens and APOs (ectopic pregnancy, spontaneous abortion, stillbirth, preterm birth or low birth weight, newborn smaller than gestational age, congenital syphilis, and infant death) and the association between risk factors and APOs. Results Of 3474 participants, 27.3% had at least one APO. Compared to those receiving WHO-recommended treatment, women who received China-recommended treatment were less likely to have APOs (odds ratio (OR) 0.47, 95% confidence interval (CI) 0.38-0.57), whereas those who received no treatment had 1.6 times higher odds of experiencing APOs. One common risk factor across different APOs was high levels of log2-transformed toluidine red unheated serum test (TRUST) titers before treatment (OR 1.14, 95% CI 1.10-1.19). China-recommended treatment was effective in reducing APOs for those with TRUST ≥ 1 : 8 (OR 0.21, 95% CI 0.14-0.29) and those with TRUST < 1 : 8 (OR 0.62, 95% CI 0.50-0.77). Conclusions Syphilis-seropositive women receiving China-recommended treatment had lower odds of APOs, especially when TRUST titers before treatment were high. Findings can be used to guide health professionals to reduce APOs among syphilis-infected mothers and promote nationwide use of China-recommended treatment.
α 1-Adrenergic Receptor Blockade by Prazosin Synergistically Stabilizes Rat Peritoneal Mast Cells

Background Adrenaline quickly inhibits the release of histamine from mast cells. Besides β2-adrenergic receptors, several in vitro studies also indicate the involvement of α-adrenergic receptors in the process of exocytosis. Since exocytosis in mast cells can be detected electrophysiologically by the changes in the membrane capacitance (Cm), its continuous monitoring in the presence of drugs would determine their mast cell-stabilizing properties. Methods Employing the whole-cell patch-clamp technique in rat peritoneal mast cells, we examined the effects of adrenaline on the degranulation of mast cells and the increase in the Cm during exocytosis. We also examined the degranulation of mast cells in the presence or absence of α-adrenergic receptor agonists or antagonists. Results Adrenaline dose-dependently suppressed the GTP-γ-S-induced increase in the Cm and inhibited the degranulation from mast cells, which was almost completely erased in the presence of butoxamine, a β2-adrenergic receptor antagonist. Among α-adrenergic receptor agonists or antagonists, high-dose prazosin, a selective α1-adrenergic receptor antagonist, significantly reduced the ratio of degranulating mast cells and suppressed the increase in the Cm. Additionally, prazosin augmented the inhibitory effects of adrenaline on the degranulation of mast cells. Conclusions This study provided electrophysiological evidence for the first time that adrenaline dose-dependently inhibited the process of exocytosis, confirming its usefulness as a potent mast cell stabilizer. The pharmacological blockade of α1-adrenergic receptor by prazosin synergistically potentiated such mast cell-stabilizing property of adrenaline, which is primarily mediated by β2-adrenergic receptors.
Population dynamics of Western corn rootworm beetles on different varieties of maize identified using pheromone and floral baited traps

SUMMARY The present paper presents details of the population dynamics of Diabrotica v. virgifera LeConte beetles on six maize varieties of three different maturity classes, i.e. early (FAO 190), medium-early (FAO 250) and medium-late (FAO 280–300), grown in Central and Eastern Europe. The study was conducted in 2009/10 in the south-eastern part of Poland. The D. virgifera beetles were captured using two types of trap: pheromone (PTs) and floral-baited (FTs). Significant differences in beetle counts were found between: (i) the first and second year of the study (higher in 2009 than in 2010); (ii) the varieties of maize and their different growth stages; (iii) early and medium-late varieties of maize. Initially, depending on the availability of maize silk and pollen, the most numerous D. virgifera beetles were found on the early varieties followed by the medium-late varieties. The study also revealed a significant difference in the performance of the two types of trap used to monitor the number of adults, particularly during the initial period when arrival rates were high. Pheromone traps were more effective in catching D. virgifera beetles, especially during the flowering stage of maize. Floral-baited traps were most effective at the end of the active growth of maize, when the preferred food of D. virgifera was unavailable.
Weed suppression by annual legume cover crops in no-tillage corn

Cover crops often reduce density and biomass of annual weeds in no-till cropping systems. However, cover crops that over-winter also have the potential to reduce crop yield. Currently, there is an interest in annual medics (Medicago spp.) and other annual legumes that winter-kill for use as cover crops in midwestern grain cropping systems. A 2-yr study was conducted at East Lansing and the Kellogg Biological Station, Michigan, to investigate the influence of annual legume cover crops on weed populations. Two annual medic species [burr medic (M. polymorpha cv. Santiago) and barrel medic (M. truncatula Gaertn. cv. Mogul)], berseem clover (Trifolium alexandrinum L. cv. Bigbee), and medium red clover (Trifolium pratense L.) were no-till seeded as cover crops into winter wheat (Triticum aestivum L.) stubble in a winter wheat/corn (Zea nays L.) rotation system. Density of winter annual weeds were between 41 and 78% lower following most cover crops when compared with no cover control in 2 out of 4 site years, while dry weight was between 26 and 80% lower in all 4 site years. Impact of cover crops on the density of summer annual weeds was infrequent; however, weed dry weights were reduced by 70% in 1995 following burr medic and barrel medic. Dry weight of perennial weeds before corn planting were 35 to 75% lower following annual legumes compared with the control, while weed density was not affected. This study indicated a potential for annual legumes to reduce weed density and growth in no-till corn grain systems.
Sorafenib-Loaded Long-Circulating Nanoliposomes for Liver Cancer Therapy

A type of sorafenib- (SOR-) loaded long-circulating nanoliposome was constructed, and the targeting performance and antitumor effects of the prepared liposome were evaluated in the present study. Polyethylene glycol- (PEG-) modified long-circulating nanoliposomes (LC-NPs) were designed and prepared using reverse evaporation, and the LC-NPs were used for delivering sorafenib (LC-PEG-SOR-NPs). Then, the anti-VEGFR antibody as a targeting moiety was chemically coupled with LC-PEG-SOR-NPs to form liver cancer-targeted nanoliposomes (anti-VEGFR-LC-PEG-SOR-NPs). The drug entrapment and loading efficiency were measured. And the cancer-targeting performance and therapeutic efficiency were evaluated both in vitro and in vivo. The anti-VEGFR-LC-PEG-SOR-NPs with an average of 119.8 ± 4.2 nm showed a uniform spherical structure. The drug entrapment and loading efficiency were 92.5% and 18.5%, respectively. The killing efficiency of anti-VEGFR-LC-PEG-SOR-NPs was up to 18% after incubating with liver cancer cells for 72 h. Furthermore, the anti-VEGFR-LC-PEG-SOR-NPs could actively target at the tumor region and could efficiently inhibit tumor growth with negligible side effects. This newly designed nanoliposomes had desirable dispersibility, high drug entrapment efficiency, tumor targeting and therapeutic efficiency, and good safety. As a biocompatible nanocomposite, it was promising to become a novel and useful tumor-targeting nanodrug for liver cancer therapy.
Autophagy Suppresses Toll-Like Receptor 3-Mediated Inflammatory Reaction in Human Epidermal Keratinocytes

Autophagy, one mechanism of programmed cell death, is fundamental to cellular homeostasis. Previous studies have identified autophagy as a novel mechanism by which cytokines control the immune response. However, its precise role in immune-related inflammatory skin diseases such as psoriasis remains unclear. Thus, this study explored the functional role of autophagy in psoriatic inflammation of epidermal keratinocytes. Strong light chain 3 immunoreactivity was observed in epidermal keratinocytes of both human psoriatic lesions and imiquimod-induced mice psoriatic model, and it was readily induced by polycytidylic acid (poly (I:C)), which stimulates Toll-like receptor 3 (TLR3), in human epidermal keratinocytes in vitro. Rapamycin-induced activation of autophagy significantly reduced poly (I:C)-induced inflammatory reaction, whereas, inhibition of autophagy by 3-methyladeine increased that. Our results indicate that the induction of autophagy may attenuate TLR3-mediated immune responses in human epidermal keratinocytes, thus providing novel insights into the mechanisms underlying the development of inflammatory skin diseases including psoriasis.
ADAPTIVENESS OF CATTLE EGRET'S (BUBULCUS IBIS) FORAGING

Cattle Egrets (Bubulcus ibis) feeding in close association with cattle catch insect prey at a significantly higher rate and expend less energy than do those foraging alone. Cattle Egrets once had a strong association with grazing cattle, but have now shifted themselves behind tractors specially in inundated agricultural fields. Captures per minute were 2.06 for the egrets feeding near the head, 0.85 while sharing with a cow and lowest when the egrets were feeding alone. The egrets with exclusive access to a cow always foraged better and caught significantly more number of prey than the others. A comparison between cattle and tractor in terms of capture per minute reveals the tractor to be more efficient in exposing the prey. Probably it wont be unfair to rename a Cattle Egret a Tractor Egret looking at its adaptiveness in foraging efficiently with tractors!