Miracle-dz/UniFAR-FTUs huggingface dataset:
Hypolipidemic effect of garlic and thyroid function.

: Male Sprague-Dawley rats were maintained on cholesterol and garlic oil for 12 weeks. Cholesterol induced hyperlipidemia was controlled by garlic feeding. Garlic treatment did not alter the concentrations of circulating thyroid hormones and thyroidal uptake of radioiodine. The results indicate that the hypolipidemic effect of garlic is probably not mediated through the thyroid.
The First Pathogenic A Point h.l(utation Is Discovered Lymphoma

We describe a novel point mutation in the mitochondrial DNA transfer RNA methionine gene, a G-to-A transition at position 4450, in a patient with a splenic lymphoma with villous lymphocytes. The p? tient's lymphocytes were remarkable by, the presence of large cytoplasmic inclusions demonstrated as abnormal mitochondria by electron microscopy and led to the discovery of the mutation using denaturing gradient gel electrophoresis as a screening procedure. The pathogenic potential of the mutation was clearly established by the following criteria. It was absent in a control population. It involves a nucle. otide that is highly conserved along the phylogenetic tree. The mutation was heteroplasmic and, when present in a high proportion, was associated with morphological alterations of the mitochondria, with defects of respiratory chain complexes activities and with a decrease in the mitochondrially encoded cytochrome c oxidase subunit II. Transfer of the mutation in Rho0 cells allowed to demonstrate its association with a severe respiratory chain dysfunction. However, although the pathogenicity of the mutation was clearly demonstrated, its link with the patient disease remained disputable.
Evolution du fardeau génétique et des traits liés à la reproduction au cours d'une invasion biologique

Cette these porte un regard evolutif sur les invasions biologiques qui sont une menace ecologique, economique et sanitaire grandissante.Qu'ils en soient la cause ou la consequence, les invasions sont en effet le theâtre de changements evolutifs rapides et importants.Ces changements peuvent etre lies a une difference de pression de selection entre l'aire d'origine et l'aire envahie, mais peuvent aussi etre inities par des evenements demo-genetiques comme un goulot d'etranglement demographique ou l'admixture (hybridation intra-specifique) entre populations genetiquement differentes.Les changements evolutifs concernent aussi bien des traits d'histoire de vie lies a la reproduction que le fardeau genetique et la depression de consanguinite.La forte derive genetique qui peut se produire au cours d'un goulot d'etranglement peut conduire a la purge ou la fixation rapide d'alleles deleteres responsables du fardeau genetique.Les trais de reproduction peuvent eux aussi influencer directement l'issue d'une invasion, au travers du taux d'accroissement demographique de la population.Ils peuvent aussi avoir un effet indirect sur le succes d'introduction en modifiant l'intensite des effets des evenements demo-genetiques.Au cours de cette these, j'ai etudie l'evolution du fardeau genetique et de traits de reproduction au cours d'une invasion biologique grâce a (i) une serie d'experiences sur l'espece envahissante modele Harmonia axyridis (la coccinelle asiatique) et a (ii) un modele theorique de dynamique de la frequence d'un allele deletere dans une population subissant un goulot d'etranglement.Mes resultats montrent que les populations envahissantes ont des traits de reproduction plus performants que celles de l'aire native.En particulier, les femelles envahissantes presentent une fecondite plus elevee et fecondent leurs œufs avec le sperme d'un plus grand nombre de mâles. Il n'existe pas, chez cette espece, de mecanisme evident d'evitement de la consanguinite, bien que les populations de l'aire native souffrent de depression de consanguinite contrairement a celles de l'aire envahie.La depression de consanguinite peut evoluer tres vite chez cette espece en cas de fort goulot d'etranglement.Dans les conditions experimentales, les alleles deleteres etaient parfois purges, mais ont souvent ete fixes dans la population au cours d'un goulot.Enfin, le modele theorique a montre que les probabilites de perte ou de fixation d'un allele deletere recessif peuvent toutes deux augmenter rapidement par derive au cours d'un goulot d'etranglement d'intensite moderee.Ces resultats soulignent l'importance du hasard sur le succes d'une invasion biologique.Puisque la probabilite d'emergence de combinaisons genomiques favorables a l'invasion augmente avec le nombre d'introduction, limiter le nombre d'evenements d'introduction peut s'averer determinant pour prevenir de futures invasions biologiques.
Kinetics of non enzymatic browning in model systems simulating clarified apple juice

Model food systems containing sugars, organic acids and the amino acids asparagine, aspartic and glutamic acids, condidered to be the major clarified apple juice components, were used to study non enzymatic browning (NEB). The model solutions were prepared to 50 o , 60 o and 70 o Brix, and stored at tempertures ranging from 15 to 37 o C. Colour, pH, acidity and 5-hydroxymethylfurfural (5-HMF) formation were determined periodically over 180 days
Biology and Management of Deepwater Snappers of the Hawaiian Archipelago

Commercial and recreational deepwater (100-400 m) bottom-fishing in Hawaii targets a multispecies group of lutjanid snappers. Relatively little is known about the life history of these species. Research in Hawaii and elsewhere in the tropical Pacific suggests that most of the species are slow growing, long lived, and have a relatively high age at sexual maturity. Stock assessment is difficult because of the multispecies nature of the fishery. However, recent analysis of commercial fishery data indicates that some of the species may currently be overexploited. Research is underway to determine the efficacy of management measures such as minimum-size limit changes or seasonal and spatial fishery closures to maintain optimal spawning biomass.
Expression of DNA Damage Response Molecules PARP1, γH2AX, BRCA1, and BRCA2 Predicts Poor Survival of Breast Carcinoma Patients 1 See-HyoungPark*, SangJaeNoh † ,KyoungMinKim † ,

BACKGROUND: Poly(ADP-ribose) polymerase 1 (PARP1), γH2AX, BRCA1, and BRCA2 are conventional molecular indicators of DNA damage in cells and are often overexpressed in various cancers. In this study, we aimed, using immunohistochemical detection, whether the co-expression of PARP1, γH2AX, BRCA1, and BRCA2 in breast carcinoma (BCA) tissue can provide more reliable prediction of survival of BCA patients. MATERIALS AND METHODS: We investigated immunohistochemical expression and prognostic significance of the expression of
Firms' innovation capabilitybuilding paths and the nature of changes in learning mechanisms : multiple case-study evidence from an emerging economy

Although much has been written about organizational-level learning, there is a dearth of empirical studies that explore the role of changes in the nature of firm-centred learning mechanisms in affecting inter-firm differences and similarities in the accumulation of innovation capabilities, especially among firms from emerging economies, known as latecomers. By examining the relationships between these issues based on fieldwork evidence from 13 natural resource-processing firms in Brazil (1950-2000s), this study found that: (1) firms that combined the use of external and internal learning mechanisms with increased intensity and quality achieved higher innovation capability levels than firms that used these learning mechanisms with limited frequency and unchanged quality over time; (2) the relative importance of both external and internal learning mechanisms changed as firms’ capabilities approached world-leading levels; (3) some combinations of external and internal learning mechanisms were associated with the attainment of particular innovation capability levels. Therefore, if latecomer firms expend limited efforts in using and deliberately changing the intensity and, mainly, the quality of both external and internal learning mechanisms over time, they will deepen their innovation capabilities slowly and will remain innovation ‘followers’ rather than becoming world-leading innovators. Using a novel approach that explores the relationship between latecomer firms’ innovation capability-building and the extent of changes in the underlying learning mechanisms, this paper furthers our understanding of the nature and dynamics of learning and its role as a primary source of firms’ international innovation performance. It also challenges recent approaches that seem to over emphasize open learning processes and post-Chandlerian forms of learning as the leading sources of firms’ innovation capabilities.
Fast Radio Bursts and their possible origin as collisions between stars and cold dark matter in the form of primordial black holes

Fast Radio Bursts (FRBs) are ultra-brief, ultra-powerful bursts of energy of unknown source that seem to be originating in distant galaxies. Here, we propose that they could be produced when primordial black holes, a cold dark matter candidate, collide with stars, via the phenomenon of superradiance occurring in the plasma of the transition region of stars. We calculate the number of such collisions per year, and compare it to the estimates of the rates of FRB events in the Universe. We find that, even with the most generous assumptions, the rate of FRBs cannot be fully accounted for by this source alone. Thus, whilst this is a plausible source of FRBs, it cannot be the only one.
Efficacy and Safety of Stem Cell Therapy for T1DM: An Updated Systematic Review and Meta-Analysis

Background The long-term insulin therapy for type 1 diabetes mellitus (T1DM) fails to achieve optimal glycemic control and avoid adverse events simultaneously. Stem cells have unique immunomodulatory capacities and have been considered as a promising interventional strategy for T1DM. Stem cell therapy in T1DM has been tried in many studies. However, the results were controversial. We thus performed a meta-analysis to update the efficacy and safety of stem cell therapy in patients with T1DM. Methods We systematically searched the Medline, EMBASE, Cochrane Central Register of Controlled Trials, ClinicalTrials.gov, Web of Science, Wan Fang Data, China National Knowledge Infrastructure, VIP database, and the Chinese Biomedical Literature Database (SinoMed) for relevant studies published before March 19, 2019. The outcomes included parameters for glycemic control (i.e., glycosylated hemoglobin (HbA1c) levels and insulin dosages), β cell function (i.e., fasting C-peptide levels and area-under-curve of C-peptide concentration (AUCC)), and relative risk of adverse events. Statistical analysis was conducted by using RevMan 5.3 and Stata 12.0. Results Five randomized controlled trials (RCTs) and eight nonrandomized concurrent control trials (NRCCTs) with a total of 396 individuals were finally included into the meta-analysis. Among RCTs, stem cell therapy could significantly reduce HbA1c levels (MD = −1.20, 95% CI -1.91 to -0.49, P = 0.0009) and increase fasting C-peptide levels (MD = 0.25, 95% CI 0.04 to 0.45, P = 0.02) and AUCC (SMD = 0.66, 95% CI 0.13 to 1.18, P = 0.01). Stem cell therapy could also reduce insulin dosages (SMD = −2.65, 95% CI -4.86 to -0.45, P = 0.02) at 6 months after treatment. NRCCTs also had consistent results. Furthermore, RCTs showed stem cell therapy did not increase relative risk of gastrointestinal symptom (RR = 0.69, 95% CI 0.14 to 3.28, P = 0.64) and infection (RR = 0.97, 95% CI 0.40 to 2.34, P = 0.95). However, NRCCTs showed stem cell therapy increased relative risk of gastrointestinal symptom (RR = 44.49, 95% CI 9.20 to 215.18, P < 0.00001). Conclusion Stem cell therapy for T1DM may improve glycemic control and β cell function without increasing the risk of serious adverse events. Stem cell therapy may also have a short-term (3-6 months) effect on reducing insulin dosages.
Persistence of tick-borne encephalitis virus in monkeys. VII. Some features of the immune response.

: Tick-borne encephalitis (TBE) virus persists in experimentally infected rhesus monkeys in the presence of humoral antibodies. Various dynamics of the humoral response (stable, increasing, decreasing, undulatory titres) have been noted, associated with complete or incomplete set of antibodies. Always present were the virus-neutralizing antibodies, often the complement-fixing antibodies, less frequently precipitating and haemagglutination inhibition (HI) antibodies were found. There was a correlation between the set of antibodies present and the virus-specific antigens expressed; the persisting TBE virus was usually deficient in haemagglutinin synthesis. In cases of asymptomatic infection a more expressed and long-lasting immunity as observed with the persistence of TBE virus in organs of the immune system.
Morphological Observation of Polylactide-b-Poly (Ethylene Glycol)-b- Polylactide Triblock Copolymers Stereocomplex Films

The objectives of this work were to prepare PLLA-PEG-PLLA/PDLA-PEG-PDLA blend films with and without tetracycline by solvent casting method and to observe their morphology drug under the scanning electron microscope (SEM). The results found that film prepared from pure PLLA-PEG-PLLA had smooth surfaces but composed of some small pores with tetracycline. The PLLA-PEG-PLLA/PDLAPEG-PDLA blend films showed varied in surfaces and textures depending on the PDLA-PEG-PDLA ratios used. All blend films had small pores on their surfaces but still had homogeneous texture. The number of pores smooth and dense texture of the blend films were gradually increased when the ratio of PDLA-PEGPDLA increased. This confirmed that stereocomplexation formation between both copolymers. The obtained results indicated the potential of blend films for drug delivery system development.
Sealworms (Pseudoterranova decipiens) in shorthorn sculpin (Myoxocephalus scorpius) from the outer Oslofjord

Sealworms, Pseudoterranova decipiens, are found in several fish species, and generally have a high prevalence in cod (Gadus morhua) and sculpins (Myoxocephalus scorpius). In the outer Oslofjord the final host is common seals (Phoca vitulina Linne, 1758), and here there are two colonies of these seals: a small population of 150 – 400 individuals in the outer Hvaler skerries in Norway and a large population of more than 2000 individuals in the Koster archipelago in Sweden. A feature of the sealworm life cycle in these habitats is that sculpins (Myoxocephalus scorpius) act as an important transmitter from invertebrates to cod. Heavily infested seals have eaten cod which have consumed heavily infected sculpins. The purpose of this project was to compare the sculpins found from Hvaler and Koster in order to investigate the effect of the number of common seals on the infection levels in sculpins. We investigated 107 sculpins from the Hvaler Islands in 2009 and 161 sculpins from the Koster archipelago in the 1990’s. Females constituted slightly less than 70 % of the samples and had a significant different age structure than males. While the females were between 1.5 and 4.5 years old, the males achieved one year less: 1.5 – 3.5 years. All fish were between 12 and 29 cm. Females were approx. 5 cm longer than males. In Hvaler around 25 % of the sculpins were infested by sealworms and the number of sealworms per fish varied between 0 and 4. On average, the number of sealworms per investigated fish (abundance) was 0.4 in Hvaler, and the number of sealworms per infested fish (intensity) was 1.6. In Koster around. 85 % of the sculpins were infested by sealworms and the number of sealworm per fish varied between 0 and 34 with the exception of 102 sealworms in one female. On average, the number of sealworms per investigated fish was 6.4, and the number of sealworms per infested fish (intensity) was 7.5. There was no correlation between the number of sealworm and weight of the fish. In the Hvaler Islands, with few common seals, the number of sealworms per fish followed a Poisson distribution. In the Koster Islands with many common seals, the number of sealworms per fish had a large deviation from the Poisson distribution. In addition to the abundance of seals, the diet of sculpins may contribute to the observed differences in the distribution of sealworms in sculpins in the two areas.
PRIVACY ISSUES IN WIRELESS MOBILE COMPUTING: A REVIEW

: This paper aims to examine privacy issues in mobile computing technology as the main challenge that face businesses operate in such environment, due to the capability of this technology to collect a lot of personal environment consumers may afraid from an invasion of their personal privacy. Based on academic studies we will discuss the privacy challenges in different mobile computing application and how this challenge concerns mobile consumers and influence their perceptions toward accepting mobile computing applications in this environment. Numerous privacy issues are discovered, businesses operate environment should consider these issues and address various privacy issues risk their consumers. Numbers of privacy protection solutions in mobile computing environment will be discussed, businesses should adopt appropriate solutions in order to gain consumers trust and increasing their interesting; and continues compete in such environment successfully; otherwise growth of mobile computing applications will be at the risk.
Cerebral oxygenation as measured by near-infrared spectroscopy in neonatal intensive care: correlation with arterial oxygenation

目的 评估早产新生儿脑氧合(rScO2)和动脉氧合(PaO2)的相关性；通过近红外光谱法(NIRS)测脑氧合，通过动脉血气测动脉氧合。 方法 研究对象为2015年4～8月就诊于澳大利亚Randwick NSW皇家妇女医院留置动脉血管导管未满37周胎龄的早产儿。 在动脉血气采样之前把NIRS的传感器放在头部前外侧处。 利用混合线性模型分析NIRS、血气和其他临床观测数据。 结果 纳入了22名胎龄24～31周(平均胎龄27.6周)的新生儿，获得75个数据。 没有明显发现rScO2和PaO2之间有相关关系(P＝0.37)，也没有发现rScO2和临床相关参数SaO2(P＝0.06)，SpO2(P＝0.44)和PaCO2(P＝0.79)有明显相关性。 结论 此研究并没有发现在临床状态稳定的早产儿其NIRS值和PaO2有明显相关关系。 这些结果突出了在新生儿重症监护病房中NIRS在临床解释中的一些困难。 今后需要更多的研究来确定NIRS对早产儿治疗的适用性。
Social monogamy and egg production in the snapping shrimp Alpheus brasileiro (Caridea: Alpheidae) from the south-eastern coast of Brazil

This study tested for social monogamy in Alpheus brasileiro Anker, 2012. We also analysed egg production in this species. Sampling was conducted bimonthly from March 2013 to January 2014, and specimens were collected manually in the intertidal estuarine zone of Cananéia, São Paulo, Brazil. A total of 186 specimens (92 males and 94 females) were captured, and ~46% of them were found living in heterosexual pairs. The carapace length (CL mm) of paired males and females was positively correlated. We analysed 35 females carrying eggs underneath the abdomen: 28 of these females had eggs in stage I of development, four had eggs in stage II, and three had eggs in stage III. The average (±SD) mean fecundity for females carrying early (stage I) eggs was 149 (±93) eggs. Egg volume differed significantly among developmental stages, with a 35.4% increase in egg volume between stages I and III. The egg volume and size (CL) of females correlated positively. A positive correlation between the number of eggs and carapace length was found, with a proportional increase in the number of eggs according to the size of females. Our results suggest that the studied population of A. brasileiro is socially monogamous and provide the first insights into egg production in this species.
Variability and Genetic Divergence in Vegetable Cowpea

Genetic variability and divergence studies conducted on thirty seven genotypes of vegetable cowpea revealed significant differences for all the twelve characters studied. High phenotypic coefficient of variation and genotypic coefficient of variation were noticed for fruit yield. pods/plant and weight of pod. High heritability coupled with high genetic advance were also observed for the above characters indicating additive gene action and emphasized the effectiveness of selection for the improvement of these traits. The thirty seven genotypes were grouped into eleven clusters using Mahalanobis D 2 statistics. In general, the intercluster distances were higher than intracluster distances. The maximum intercluster distance was between clusters VIII and X followed by clusters VI and X and clusters VIII and IX , respectively. The intracluster distance was maximum in cluster VII.
Effects of Scutellaria baicalensis and Lonicera japonica extract mixture supplementation on growth performance, nutrient digestibility, blood profiles and meat quality in finishing pigs

Abstract A total of 135 [(Landrace × Yorkshire) × Duroc] finishing pigs with initial body weight (BW) of 44.2 ± 2.23 kg were used in this 12-wk trial to evaluate the effects of an herbal extract mixture (Scutellaria baicalensis and Lonicera japonica, HEM) supplementation on growth performance, nutrient digestibility, blood profiles and meat quality. The dietary treatments were supplemented with 0, 0.025% and 0.05% HEM, respectively. There were 9 replications per treatment with 5 pigs per pen. During 1–6 wk, the inclusion of HEM linearly increased (p < 0.05) the final BW and average daily gain (ADG). During 7–12 wk, dietary HEM supplementation led to a greater (linear, p < 0.05) final BW at the end of 12 wk. Throughout the experiment, the overall ADG and gain:feed ratio were increased (linear, p < 0.05) in pigs fed HEM supplemental diet. The administration of HEM improved (linear, p < 0.05) the nutrient digestibility of dry matter, nitrogen and energy. Providing HEM diet also reduced (linear, p < 0.05) the serum cortisol concentration. Furthermore, the inclusion of graded levels of HEM linearly increased (p < 0.01) the pH of meat, and the 2-thiobarbituric acid reactive substances (TBARS) were linearly decreased (p < 0.05) by HEM supplementation. Taken together, administration of HEM (0.025% and 0.05%) could improve growth performance and nutrient digestibility, decrease serum cortisol levels, as well as benefit the meat quality in finishing pigs.
Host stage preference and suitability of Allotropa suasaardi Sarkar & Polaszek (Hymenoptera: Platygasteridae), a newly identified parasitoid of pink cassava mealybug, Phenacoccus manihoti (Homoptera: Pseudococcidae)

Allotropa suasaardi Sarkar & Polaszek (Hymenoptera: Platygasteridae) has been recently reported as a gregarious endoparasitoid of the pink cassava mealybug, Phenacoccus manihoti Matile-Ferrero (Homoptera: Pseudococcidae) in Thailand. With the aim of improving mass production of this parasitoid, laboratory experiments were conducted comparing the parasitoid’s preference on different host stages of mealybug, host suitability and its effect on parasitism, development, progeny fitness and sex ratio. All nymphal stages and adult of P. manihoti were parasitized by the parasitoid. However, host stage preference and suitability tests showed that the parasitoid had a significant preference for the older host stages. Percentage parasitization was higher in the third instar and early adult female stages compared with the first and second instar host. Mean developmental time for male parasitoids was shorter than for the females. Higher percentage emergence of parasitoid was observed from older mealybugs. Sex ratios of the offspring produced by the parasitoid were varied in different host stages and the ratio of female to male was higher in the older host stages. The implication of this host selection behavior for mass rearing of A. suasaardi and for evaluating it in a biological control program of the cassava mealybug are discussed.