Miracle-dz/UniFAR-FTUs huggingface dataset:
The Health Effects of Real-World Dual Use of Electronic and Conventional Cigarettes versus the Health Effects of Exclusive Smoking of Conventional Cigarettes: A Systematic Review

Background: A high prevalence of dual use of e-cigarettes and conventional cigarettes has been reported across the world. Methods: A systematic search was carried out. We included original articles on any topic relevant to health, excluding mental health, in all languages. The PRISMA guidelines were followed. Both reviewers independently screened and read all publications. We compared dual use with exclusive smoking of conventional cigarettes (ESCC). Results: Fifty-two publications (49 studies) were included. Thirteen papers/10 studies were prospective. There was great heterogeneity across studies. Many methodological weaknesses, such as inaccurate exposure measurement, lack of adjustment for former tobacco consumption, and lack of significance testing were identified. Most prospective studies found dual use to be at least as harmful as ESCC. The longest follow-up was six years. Most of the best available cross-sectional studies found dual use associated with the same and, in several studies, significantly higher risk of self-reported symptoms/disease than in ESCC. The intensity of cigarette smoking seems associated with worse health. Conclusion: Existing studies indicate that dual use is at least as, or probably even more, harmful than ESCC. Due to the predominance of cross-sectional studies and the methodological weaknesses we judged the overall certainty of the evidence as “low certainty”.
The Sym2Int program: going from symmetries to interactions

Model builders often need to find the most general Lagrangian which can be constructed from a given list of fields. These fields are actually representations of the Lorentz and gauge groups (and maybe of some discrete symmetry group as well). I will describe a simple program (Sym2Int) which helps to automate this task by listing all possible interactions between Lorentz/gauge group representations.
Prevalence of Toxoplasma gondii Antibodies and Risk Factor Investigation in Portuguese Veterinarians: A Matched Case–Control Study

(1) Background: Toxoplasma gondii is a widespread zoonotic agent that greatly impacts Public Health, being responsible for one of the most important parasitic zoonosis worldwide. T. gondii has a heteroxenous life cycle, with cats being the definitive hosts and all warm-blooded animals, including humans, being intermediate hosts. Veterinary practitioners (VP) may be at a higher risk than the general population for T. gondii infection, as they have direct and daily contact with many animal species. The aim of the present study was to ascertain if VP were more likely to be anti-T. gondii IgG seropositive than the general population, as well as to understand if age, accidents with blood-contaminated sharps (cross-blood contamination), gender, working years, and geographic regions play a role as risk factors for T. gondii infection. For this purpose, a case–control study using archived samples was performed. (2) Methods: A total of 350 veterinary practitioners were tested using a commercial semiquantitative enzyme immunoassay for anti-T. gondii IgG. From the general population, 175 anonymous volunteers (matched with cases by region, age, and gender) were studied for anti-T. gondii IgG. (3) Results: There was no statistical difference found between the presence of anti-T. gondii IgG in practitioners (26%; CI = 21.40–30.60%) and the general population (33.14%; CI = 26.17–40.12%) (p = 0.108). Univariate and multivariate analysis showed that only age (older groups) was found to be associated with a higher prevalence of anti-T. gondii IgG, with significant p values (p < 0.05) for both univariate and multivariate analysis. (4) Conclusions: To the best of our knowledge, this is the first case–control study fully focused on the prevalence of anti-T. gondii IgG in VP in Portugal, showing that there was no significant risk for T. gondii infection in veterinarians exposed daily and repeatedly to different species of animals.
Integrable viscous conservation laws

We propose an extension of the Dubrovin–Zhang perturbative approach to the study of normal forms for non-Hamiltonian integrable scalar conservation laws. The explicit computation of the first few corrections leads to the conjecture that such normal forms are parameterized by one single functional parameter, named the viscous central invariant. A constant valued viscous central invariant corresponds to the well-known Burgers hierarchy. The case of a linear viscous central invariant provides a viscous analog of the Camassa–Holm equation, that formerly appeared as a reduction of two-component Hamiltonian integrable systems. We write explicitly the negative and positive hierarchy associated with this equation and prove the integrability showing that they can be mapped respectively into the heat hierarchy and its negative counterpart, named the Klein–Gordon hierarchy. A local well-posedness theorem for periodic initial data is also proven. We show how transport equations can be used to effectively construct asymptotic solutions via an extension of the quasi-Miura map that preserves the initial datum. The method is alternative to the method of the string equation for Hamiltonian conservation laws and naturally extends to the viscous case. Using these tools we derive the viscous analog of the Painlevé I2 equation that describes the universal behaviour of the solution at the critical point of gradient catastrophe.
Soy Isoflavones and Bone Health: Focus on the RANKL/RANK/OPG Pathway

Bone remodels via resorption and formation, two phenomena that continuously occur in bone turnover. The RANKL/RANK/OPG pathway is one of the several mechanisms that affect bone turnover. The RANKL/OPG ratio has a substantial role in bone resorption. An imbalance between formation and resorption is related to an increased RANKL/OPG balance. OPG, a member of this system, can bind to RANKL and suppress RANK-RANKL interaction, and subsequently, inhibit further osteoclastogenesis. The serum levels of RANKL and OPG in the bone microenvironment are vital for osteoclasts formation. The RANK/RANKL/OPG system plays a role in the pathogenesis of bone disorders. This system can be considered a new treatment target for bone disorders. Soy isoflavones affect the RANK/RANKL/OPG system through numerous mechanisms. Soy isoflavones decrease RANKL levels and increase OPG levels. Therefore, isoflavones improve bone metabolism and decrease bone resorption. Soy isoflavones decrease serum markers of bone resorption and improve bone metabolism. However, while the available data are promising, the results of several studies reported no change in RANKL and OPG levels with isoflavones supplementation. In this regard, current evidence is insufficient for conclusive approval of the efficacy of isoflavones on RANKL/RANK/OPG and further research, including animal and human studies, are needed to confirm the effect of soy isoflavones on the RANKL/RANK/OPG pathway. This study was a review of available evidence to determine the role of isoflavones in bone hemostasis and the RANK/RANKL/OPG pathway. The identification of the effects of isoflavones on the RANKL/RANK/OPG pathway directs future studies and leads to the development of effective treatment strategies for bone disorders.
A Model of Dark Matter, Leptogenesis, and Neutrino Mass from the $B-L$ Violation just above the Electroweak Scale

I suggest an extension of the SM by introducing a dark sector with the local $U(1)_{D}$ symmetry. The particles in the dark sector bring about the new physics beyond the SM. In particular the global $B-L$ symmetry is violated just above the electroweak scale, this becomes a common origin of the tiny neutrino mass, the cold dark mater and the baryon asymmetry. The model can not only account for the tiny neutrino mass and the "WIMP Miracle", but also achieve the leptogenesis around the electroweak scale. Finally, it is very possible that the model predictions are tested in near future experiments.
Revealing the nebular properties and Wolf-Rayet population of IC10 with Gemini/GMOS

We present a deep imaging and spectroscopic survey of the Local Group irregular galaxy IC10 using Gemini North and GMOS to unveil its global Wolf-Rayet (WR) population. We obtain a star formation rate (SFR) of 0.045 +/- 0.023 Msun/yr, for IC10 from the nebular Halpha luminosity, which is comparable to the SMC. We also present a revised nebular oxygen abundance of log(O/H) + 12 = 8.40 +/- 0.04, comparable to the LMC. It has previously been suggested that for IC10 to follow the WR subtype-metallicity dependance seen in other Local Group galaxies, a large WN population awaits discovery. Our search revealed 3 new WN stars, and 6 candidates awaiting confirmation, providing little evidence to support this claim. The new global WR star total of 29 stars is consistent with the LMC population when scaled to the reduced SFR of IC10. For spectroscopically confirmed WR stars, the WC/WN ratio is lowered to 1.0, however including all potential candidates, and assuming those unconfirmed to be WN stars, would reduce the ratio to ~0.7. We attribute the high WC/WN ratio to the high star formation surface density of IC10 relative to the Magellanic Clouds, which enhances the frequency of high mass stars capable of producing WC stars.
Strength of Zerodur® for mirror applications

Zerodur® is a well-known glass-ceramic used for optical components because of its unequalled dimensional stability under thermal environment. In particular it has been used since decades in Thales Alenia Space’s optical payloads for space telescopes, especially for mirrors. The drawback of Zerodur® is however its quite low strength, but the relatively small size of mirrors in the past had made it unnecessary to further investigate this aspect, although elementary tests have always shown higher failure strength. As performance of space telescopes is increasing, the size of mirrors increases accordingly, and an optimization of the design is necessary, mainly for mass saving. Therefore the question of the effective strength of Zerodur® has become a real issue. Thales Alenia Space has investigated the application of the Weibull law and associated size effects on Zerodur® in 2014, under CNES funding, through a thorough test campaign with a high number of samples (300) of various types. The purpose was to accurately determine the parameters of the Weibull law for Zerodur® when machined in the same conditions as mirrors. The proposed paper will discuss the obtained results, in the light of the Weibull theory. The applicability of the 2-parameter and 3-parameter (with threshold strength) laws will be compared. The expected size effect has not been evidenced therefore some investigations are led to determine the reasons of this result, from the test implementation quality to the data post-processing methodology. However this test campaign has already provided enough data to safely increase the allowable value for mirrors sizing.
Observational Evidence of Magnetic Reconnection for Brightenings and Transition Region Arcades in IRIS Observations

By using a new method of forced-field extrapolation, we study the emerging flux region AR11850 observed by the Interface Region Imaging Spectrograph and Solar Dynamical Observatory. Our results suggest that the bright points (BPs) in this emerging region exhibit responses in lines formed from the upper photosphere to the transition region, which have relatively similar morphologies. They have an oscillation of several minutes according to the Atmospheric Imaging Assembly data at 1600 and 1700 Å. The ratio between the BP intensities measured in 1600 and 1700 Å filtergrams reveals that these BPs are heated differently. Our analysis of the Helioseismic and Magnetic Imager vector magnetic field and the corresponding topology in AR11850 indicates that the BPs are located at the polarity inversion line and most of them are related to magnetic reconnection or cancelation. The heating of the BPs might be different due to different magnetic topology. We find that the heating due to the magnetic cancelation would be stronger than the case of bald patch reconnection. The plasma density rather than the magnetic field strength could play a dominant role in this process. Based on physical conditions in the lower atmosphere, our forced-field extrapolation shows consistent results between the bright arcades visible in slit-jaw image 1400 Å and the extrapolated field lines that pass through the bald patches. It provides reliable observational evidence for testing the mechanism of magnetic reconnection for the BPs and arcades in the emerging flux region, as proposed in simulation studies.
Children’s Early Acquisition of Syntactic Category: A Corpus-Based Analysis of English Determiner-Noun Combinational Flexibility

While the generativist account posits that an abstract specification of syntactic categories is innate and children show adult-like performance from an early stage, the constructivist account postulates that children’s early acquisition of grammatical categories is item-based and reflects limited rules later. The present study tests these assumptions in a specific category, the English determiners. More specifically, we took the controlled measures of overlap (e.g., the use of definite article the and indefinite articles a/an before the same noun type) in 16 children and their mothers’ spontaneous speech as an indicator of determiner-noun combinational flexibility. A series of three studies were conducted, in which we strictly controlled the impact of differences between children and adults in lexical knowledge. In Study 1 and Study 2, we find that children’s use of determiners shows a significant difference from adults but this difference disappeared later. Furthermore, Study 3 investigates the influence of external environment with birth order and family’s social class as factors and emphasizes that the input factor is worthy of further investigation in future studies. These findings are consistent with one of the constructivist claims, namely that children’s early acquisition of determiners is not category-based and their flexibility in using determiners gradually approximates that of adults with development.
C-reactive protein–to–albumin ratio is a predictor of 1-year mortality following liver transplantation

Background Considering the importance of the inflammatory status of recipients on outcomes following liver transplantation (LT), we investigated the association between C-reactive protein–to–albumin ratio (CAR) and one-year mortality following LT and compared it with other parameters reflecting patients’ underlying inflammatory status. Methods A total of 3,614 consecutive adult LT recipients were retrospectively evaluated. Prognostic parameters were analyzed using area under the receiver operating characteristic curve (AUROC) analysis, and subsequent cutoffs were derived. For survival analysis, Cox proportional hazards and Kaplan–Meier analyses were performed. Results The AUROC for CAR to predict one-year mortality after LT was 0.68 (0.65–0.72), which was the highest compared with other inflammatory parameters, with the best cutoff of 0.34. A CAR ≥ 0.34 was associated with a significantly higher one-year mortality rate (13.3% vs. 5.8 %, log-rank P < 0.001) and overall mortality rate (24.5% vs. 12.9%, log-rank P = 0.039). A CAR ≥ 0.34 was an independent predictor of one-year mortality (hazard ratio, 1.40 [1.03–1.90], P = 0.031) and overall mortality (hazard ratio 1.39 [1.13–1.71], P = 0.002) after multivariable adjustment. Conclusions Preoperative CAR (≥ 0.34) was independently associated with a higher risk of one-year and overall mortality after LT. This may suggest that CAR, a simple and readily available biomarker, maybe a practical index that may assist in the risk stratification of liver transplantation outcomes.
Bandstructure effects in ultra-thin-body double-gate field effect transistor : A fullband analysis

The properties of an n-channel ultra-thin-body (UTB) double-gate field effect transistor (DGFET),resulting from the bandstructure of the thin film Si channel, are discussed in this paper. The bandstructure has been calculated using a ten-orbital $sp^3d^5s^*$ tight-binding method. A number of intrinsic properties including band gap, density of states, intrinsic carrier concentration, and parabolic effective mass have been derived from the calculated bandstructure. The spatial distributions of intrinsic carrier concentration and (100) effective mass, resulting from the wave functions of different contributing subbands, are analyzed. A self-consistent solution of coupled Poisson-Schrodinger equations is obtained taking the full bandstructure into account, which is then applied to analyze volume inversion. The spatial distribution of carriers over the channel of a DGFET has been calculated and its effect on effective mass and channel capacitance is discussed.
Cryptococcal antigen prevalence in HIV patients from a tertiary care centre in South India

Background and Objectives: Cryptococcosis is an opportunistic mycosis, caused by Cryptococcus neoformans. Cryptococcal meningitis is one of the most fatal opportunistic infections associated with human immunodeficiency virus (HIV) infection. The aim of this study was to find the prevalence of cryptococcal antigenemia in people living with HIV (PLHA) and also to find the prevalence of opportunistic infections among these patients. Materials and Methods: A total of 204 non duplicate samples were collected from people with HIV aged above 18 years. Samples with CD4 count less than 300 were included in the study. Cryptococcal antigen detection was done by CrAg Lateral flow assay. Results: None of the patients in our study were positive for cryptococcal antigen. Opportunistic infections were observed in 82 (40.2%) HIV positive patients. Candidiasis, tuberculosis and Pneumocystis jiroveci pneumonia were the most common opportunistic infections. Conclusion: This is the first study from the southern state of Kerala on the prevalence of Cryptococcal antigenemia among HIV positive individuals. The study showed that routine screening for cryptococcal antigen will not be cost effective in our population. Similar to other studies, eventhough candidiasis, tuberculosis and PCP were more commonly seen among people with CD4 count < 200 cells/mm3, there was no statistically significant association.
Estimation in partial linear EV models with replicated observations

The aim of this work is to construct the parameter estimators in the partial linear errors-in-variables (EV) models and explore their asymptotic properties. Unlike other related references, the assumption of known error covariance matrix is removed when the sample can be repeatedly drawn at each designed point from the model. The estimators of interested regression parameters, and the model error variance, as well as the nonparametric function, are constructed. Under some regular conditions, all of the estimators prove strongly consistent. Meanwhile, the asymptotic normality for the estimator of regression parameter is also presented. A simulation study is reported to illustrate our asymptotic results.
Three-velocity hydrodynamics of superfluid solutions

The equations of three-velocity hydrodynamics, which describe the properties of solutions of He3 in liquid He' below the point of the transition of the Fermi component to the superfluid state, are determined by specifying the thermodynamic functions and symmetric 2 X 2 matrix playing the role of the density of "the superfluid part. A calculation of the elements of this matrix is carried out on the basis of BCS theory. As a result it is shown that each of the two superfluid flows is accompanied by transport of both components of the solution. The velocities of three types of sound vibrations are calculated.
Determinants Of Treatment Adherence In Drug-Sensitive Tuberculosis Patients During The Covid-19 Pandemic

Background: During the COVID-19 pandemic in Surakarta, there were patients who were absent, failed, and dropped out of treatment. This study aims to analyze factors associated with treatment adherence of drug-sensitive tuberculosis patients (TB-SO) during the COVID-19 pandemic at the Surakarta City Public Health Center. Methods: This research method combines quantitative research with cross-sectional research. A sample of 105 patients from 10 Public Health Center (Puskesmas) in Surakarta City was obtained using a total population sampling based on inclusion and exclusion criteria. This research was conducted from April to June 2022. The research instrument used was a questionnaire, and the data was analyzed univariate and bivariate with the chi-square. Results: This study showed that more patients were adherere (79%) than non-adherent (21%). Factors related to treatment adherence were the role of health professionals (p = 0.045) and Treatment Supervisors (Pengawas Menelan Obat/PMO) support (p = 0.035). Conclusion: The role of health workers and the support provided by the PMO to patients related to adherence to treatment for TB-SO patients Therefore, it is expected that health professionals need to keep a good relationship with patients through personal counseling and need to provide socialization to PMOs.
Prevalence of DNA Mismatch Repair Deficiency in Endometrial Cancer Using Immunohistochemistry

Background: Endometrial cancer (EC) is known as the most common malignancy of the female reproductive system, suggested to be associated with hereditary nonpolyposis colorectal cancer (HNPCC) or Lynch syndrome (LS). Objectives: Therefore, the aim of the present study was to screen for LS in patients with EC using immunohistochemistry (IHC). Methods: In this retrospective cross-sectional study, the patients with EC, referred to Qaem Hospital, Mashhad, Iran, from 2015 - 2019, were enrolled. Paraffin-embedded tissue blocks were then examined via IHC for the expression of four mismatch repair (MMR) proteins, including MLH1, MSH2, MSH6, and PMS2. The demographic and tumor-related data were also extracted from medical records and pathology reports. The data were consequently analyzed at the significance level of P < 0.05. Results: A total number of 100 patients with EC were evaluated using IHC, and 12 (12%) cases were found suspected. As well, no significant relationship was observed between LS and age, tumor site, tumor histology, tumor size, tumor grade, tumor-infiltrating lymphocytes (TILs), and a family/personal history of malignancies. Conclusions: The prevalence of LS based on the IHC expression of the MMR proteins (MLH1, MSH2, MSH6, and PMS2) was 12% in the patients with EC. There was also no significant relationship between the cases suspected and the demographic and tumor-related data.
Residential Proximity to Urban Play Spaces and Childhood Overweight and Obesity in Barcelona, Spain: A Population-Based Longitudinal Study

Findings on the relationship between play spaces and childhood overweight and obesity are mixed and scarce. This study aimed to investigate the associations between residential proximity to play spaces and the risk of childhood overweight or obesity and potential effect modifiers. This longitudinal study included children living in the city of Barcelona identified in an electronic primary healthcare record database between 2011 and 2018 (N = 75,608). Overweight and obesity were defined according to the WHO standards and we used 300 m network buffers to assess residential proximity to play spaces. We calculated the risk of developing overweight or obesity using Cox proportional hazard models. A share of 29.4% of the study population developed overweight or obesity, but we did not find consistent associations between play space indicators and overweight or obesity. We did not find any consistent sign of effect modification by sex, and only some indications of the modifying role of area socioeconomic status and level of exposure. Although it is not possible to draw clear conclusions from our study, we call for cities to continue increasing and improving urban play spaces with an equitable, healthy, and child-friendly perspective.