Miracle-dz/UniFAR-FTUs huggingface dataset:
Rituximab use as induction therapy for lupus nephritis: a systematic review

Objective Rituximab (RTX) has important usage in rheumatoid arthritis and vasculitis. There remains a need for more, better, and safer treatments for patients with lupus nephritis (LN). RTX has been trialed in such patients without definitive conclusions about its effectiveness. As a role for RTX has not been clearly established for LN, we carried out a systematic review and analysis. Methods We identified 31 studies of RTX for class I–VI LN, and assessed complete renal response (CRR) and partial renal response (PRR) using criteria including serum creatinine, proteinuria, and urinary sediment. Due to differences in the pediatric presentation of the disease, studies focusing on pediatric patients were excluded. Results One randomized controlled trial (RCT) showed superiority of RTX+cyclophosphamide (CYC) versus CYC alone (64% vs. 21% CRR and 19% vs. 36% PRR). Six prospective and retrospective studies utilizing RTX monotherapy found 66% CRR or PRR in all patients. Eleven studies that investigated RTX in combination with CYC or mycophenolate mofetil (MMF) also found 66% CRR or PRR in all patients. In total, the CRR for Caucasian, East Asian, and Hispanic patients were 77%, 38%, and 28%, respectively. Conclusions RTX appeared to benefit certain LN patients, but most studies were not randomized or properly controlled, were heterogeneous in design, subjects, and LN types, and were not comparable, and must therefore be interpreted cautiously. RTX alone may not deplete B cells sufficiently for the perturbations of LN. In addition, RTX may induce responses differently among patients of different ethnic and racial backgrounds. Furthermore, there were wide variations in the baseline characteristics of the patients, namely LN class, time course of disease, age, and prior immunosuppressive use. We suggest a prospective RCT in patients aged 18–65 years with class IV LN. Ideally, the patients would not have received prior immunosuppression and would better represent different ethnicities. The treatment groups would be RTX, RTX+belimumab, CYC, and MMF groups, with pulse-dose steroids during induction followed by maintenance steroids and MMF. The CRR and PRR would be assessed at 12 and 24 months. This or a similar study might clarify RTX’s role in the treatment of LN.
Age Dependent Modification of the Metabolic Profile of the Tibialis Anterior Muscle Fibers in C57BL/6J Mice

Skeletal muscle aging is accompanied by mass reduction and functional decline, as a result of multiple factors, such as protein expression, morphology of organelles, metabolic equilibria, and neural communication. Skeletal muscles are formed by multiple fibers that express different Myosin Heavy Chains (MyHCs) and have different metabolic properties and different blood supply, with the purpose to adapt their contraction to the functional need. The fine interplay between the different fibers composing a muscle and its architectural organization determine its functional properties. Immunohistochemical and histochemical analyses of the skeletal muscle tissue, besides evidencing morphological characteristics, allow for the precise determination of protein expression and metabolic properties, providing essential information at the single-fiber level. Aiming to gain further knowledge on the influence of aging on skeletal muscles, we investigated the expression of the MyHCs, the Succinate Dehydrogenase (SDH) activity, and the presence of capillaries and Tubular Aggregates (TAs) in the tibialis anterior muscles of physiologically aging C57BL/6J mice aged 8 (adult), 18 (middle aged), and 24 months (old). We observed an increase of type-IIB fast-contracting fibers, an increase of the oxidative capacity of type-IIX and -IIA fibers, a general decrease of the capillarization, and the onset of TAs in type-IIB fibers. These data suggest that aging entails a selective modification of the muscle fiber profiles.
Validation of the Slovak version of the Wijma Delivery Expectancy/Experience Questionnaire (W-DEQ), version A.

AIM This study aimed to assess the psychometric characteristics of the Slovak translation of the version A of Wijma Delivery Expectancy/Experience Questionnaire (SW-DEQ) among healthy Slovak pregnant women. METHOD Exploratory factor analysis (EFA) of the SW-DEQ was performed. Several coefficients of internal consistency were employed for the whole scale as well as for separate factors. Concurrent/convergent validity was assessed by correlation analysis of the overall SW-DEQ score with State-Trait Anxiety Inventory, Eysenck Personality Inventory - subscales Neuroticism and Extraversion, as well as with adjusted versions of Beck Depression Inventory and Internal-External Locus of Control Scale. EFA yielded seven factors: 'lack of composure', 'negative appraisal', 'lack of self-efficacy', 'lack of positive anticipation', 'fear and hopelessness', 'loneliness', and 'concern for the child'. RESULTS The Cronbach's α of the whole scale was . 93, while for the separate factors, it ranged between . 68 and . 87. The sum score of SW-DEQ correlated weakest with extraversion (in nulliparous women) and locus of control (in multiparous women), and strongest with trait anxiety (in both groups). CONCLUSIONS The Slovak version could be considered a valid and reliable measure of fear of childbirth among pregnant Slovak women. However, the dimensional structure of the measure warrants further confirmation (Tab. 7, Ref. 33).
N-Fertilizer (Urea) Enhances the Phytoextraction of Cadmium through Solanum nigrum L.

Heavy metal contamination is currently a major environmental concern, as most agricultural land is being polluted from municipal discharge. Among various other pollutants, cadmium (Cd), one of the most harmful heavy metals, enters into the food chain through the irrigation of crops with an industrial effluent. In the present study, a pot experiment was designed to assess the effect of different nitrogen (N)-fertilizer forms in the phytoremediation of Cd through Solanum nigrum L. Two types of N fertilizers (NH4NO3 and urea) were applied to the soil in different ratios (0:0, 100:0, 0:100, and 50:50 of NH4NO3 and urea, individually) along with different Cd levels (0, 25, and 50 mg kg−1). The plants were harvested 70 days after sowing the seeds in pots. Cadmium contamination significantly inhibited the growth of leaves and roots of S. nigrum plants. Cadmium contamination also induced oxidative stress; however, the application of N-fertilizers increased the plant biomass by inhibiting oxidative stress and enhancing antioxidants’ enzymatic activities. The greatest plant growth was observed in the urea-treated plants compared with the NH4NO3-treated plants. In addition, urea-fed plants also accumulated higher Cd concentrations than NH4NO3-fed plants. It is concluded that urea is helpful for better growth of S. nigrum under Cd stress. Thus, an optimum concentration of N-fertilizers might be effective in the phytoremediation of heavy metals through S. nigrum.
Efficacy and biomarker analysis of nivolumab plus gemcitabine and cisplatin in patients with unresectable or metastatic biliary tract cancers: results from a phase II study

Background The prognosis of patients with unresectable or metastatic biliary tract cancer (BTC) is unacceptably low. This study aimed to determine the efficacy, safety and predictive biomarkers of the immune checkpoint inhibitor nivolumab in combination with chemotherapy in advanced BTCs. Methods In this open-label, single-arm, phase II trial, a chemotherapy and immunotherapy combination consisting of gemcitabine 1000 mg/m2, cisplatin 75 mg/m2 and nivolumab 3 mg/kg was administered every 3 weeks for up to six cycles. Maintenance treatment with gemcitabine plus nivolumab was administered to patients achieving disease control following the combination therapy. The primary outcome was the objective response rate. Secondary outcomes included safety, disease control rate (DCR), progression-free survival (PFS) and overall survival (OS). The exploratory objective was to assess biomarkers for predicting clinical response and prognosis. Results Thirty-two patients with a median age of 60 (range 27–69) years were enrolled. As of September 31, 2019, the median follow-up was 12.8 (95% CI 10.8 to 14.8) months. Twenty-seven response-evaluable patients received a median of 4 (IQR, 3–6) cycles of combination therapy, of whom 15 (55.6%) patients achieved an objective response, including 5 (18.6%) with a complete response (CR), and the DCR was 92.6%. Of the six patients in cohort A who were resistant to gemcitabine-based or cisplatin-based chemotherapy, one achieved CR and one achieved partial response. Thirteen of 21 chemotherapy-naive patients (61.9%) in cohort B achieved an objective response. The median PFS of all patients in cohorts A+B was 6.1 months. The median OS was 8.5 months, with a 33.3% 12-month OS rate. The most frequent grade 3 or higher adverse events were thrombocytopenia (56%) and neutropenia (22%). Fitness might be a biomarker for predicting clinical response. On-therapy changes in serum soluble FasL, MCP-1 and interferon-γ were correlated with prognosis. Conclusions Nivolumab in combination with gemcitabine and cisplatin offers promising efficacy and a manageable safety profile for patients with advanced BTCs. Trial registration number NCT03311789
A Method for Correcting the Relative Weight (Wr) Index for Seasonal Patterns in Relative Condition (Kn) with Length as Applied to Walleye in Wisconsin

Abstract We determined whether the relative weight (W r) model for walleye Sander vitreus was representative of populations in Wisconsin and if relative weight varied with length seasonally. We then developed standard condition (K n) models that correct for seasonal variation in body condition. We compiled data from 54,657 walleyes sampled during 640 surveys of 202 lakes in 30 Wisconsin counties. Weight–length relationships and mean relative weight varied more widely for Wisconsin populations than for North American populations overall. Weight–length relationships and mean relative weight varied significantly among seasons, with the highest slope (lowest intercept) and mean relative weight in spring, lowest slope (highest intercept) and mean relative weight in early summer, and intermediate slopes (and intercepts) and mean relative weights in late summer and autumn. Mean relative weight increased with length in spring, decreased with length in early summer, and did not change with length in late summer, a.
Transition to Employment Program (SUPER) for Youth at Risk: A Conceptual and Practical Model

This article describes the development, implementation, and evaluation of the transdisciplinary “Successful Pathways to Employment for youth at Risk” (SUPER) program to raise the transition readiness of youth at risk (YAR) from school into participation in adults’ responsibilities and employment. More than 10% of adolescents are at risk of dropping out of school following poor academic attainments. Schools appraise academic merit but do not develop relevant educational programs to prepare youth to transition into adult working life. The SUPER program addresses a range of knowledge and skills required for this transition. Sixty YAR from three high schools participated in the 18-week SUPER program. Comparing the pre- and postintervention results revealed that the students’ engagement with responsibilities, objective knowledge about the work world, and self-rated self-advocacy skills improved as did their supervisor-rated work performance capacity. This study confirms the contribution of the SUPER model. Its concepts, tools, principles, and community labor-market involvement through workplace internships were effective and could apply in other contexts. The SUPER model provides evidence-based knowledge translation that can bring conceptual and practical changes towards successful transition and participation of YAR in adult working roles.
Effects of feeding fodder beet and concentrates with different protein contents on dairy cows offered silage ad libitum

In two changeover design experiments, fifteen early- and sixteen late-lactation cows were used to investigate the effects of offering food beet with ad libitum grass silage and concentrates with different CP content on milk yield and quality. In Experiment 1 (early lactation) cows were offered no fodder beet (0) or 4 kg DM d−1 (4) in conjunction with one of three concentrates containing 159, 191 or 244g CP kg−1 DM (L.M.H.). Treatments were therefore 1L/0, 1L/4, 1M/0, 1M/4, 1H/0 and 1H/4. In Experiment 2 (late lactation) cows were offered the same level of fodder beet in conjunction with two concentrates containing 129 and 229 (L,H) g CP kg−1 DM. Treatments were therefore 2L/0, 2L/4, 2H/0 and 2H/4. In both experiments feeding fodder beet reduced silage DM intakes (P < 0·001) and increased total DM intake (P < 0·05 to P < 0·001). The substitution rate (r) ranged from 0·46 to 0·59kg of silage DM (kg−1 fodder beet DM). In Experiment 1, fodder beet tended to increase milk yield, composition and yield of constituents, but the effect was statistically significant for milk protein content only (P < 0·01). In Experiment 2, milk yields for 2L/0, 2L/4, 2H/0 and 2H/4 were 11·3, 12·1, 11·7 and 12·5 kg d−1 respectively (s.e.d. 0·43, non-significant), fat contents were 44·4, 47·3, 44·3 and 46·8g fat kg−1 respectively (s.e.d. 0·73, P < 0·001), protein contents were 34·3, 35·6, 35·3 and 36·2 g protein kg−1 respectively (s.e.d. 0·28, P < 0·001), fat yields were 494, 574, 512 and 579 g fat d−1 respectively (s.e.d. 20, P < 0·001) and protein yields were 385, 426, 407 and 442 g protein d−1 (s.e.d. 13, P < 0·01) respectively. Increasing CP in the concentrate significantly increased milk yield in Experiment 1 (23·9, 22·5, 23·5, 23·8, 26·2, 26·5kg d−1 for 1L/0, 1L/4, 1M/0, 1M/4, 1H/0 and 1H/4 respectively, P < 0·05). Higher CP in concentrate also resulted in significantly increased milk protein yield in early-lactation (P < 0·001) and milk protein content in late-lactation (P < 0·01) cows. There was a significant interaction between fodder beet and concentrate CP content for milk protein yield (P < 0·001) in Experiment 1.
Genetic parameters from a clonally replicated test of black spruce (Piceamariana)

A clonally replicated field test of full-sib black spruce (Piceamariana (Mill.) B.S.P.) progeny was established at four locations in Nova Scotia. Estimated variance components for 5-year height growth and survival were interpreted according to an additive–dominance–epistasis genetic model and used to derive estimates of gain from various selection and deployment strategies. Five years after striking, 64% of the total genetic variance for height growth was due to additive variance. Virtually all of the remaining nonadditive variance was composed of epistatic variances; dominance variance was negligible. Narrow-sense heritability for 5-year height growth was low at 0.059. Substantial nonadditive variance contributed to a somewhat higher estimate of broad-sense heritability at 0.093. Family-mean heritabilities were much higher: 0.823 and 0.697 for half-sib and full-sib family means, respectively. Comparable heritabilities for survival were estimated with high standard errors and were considered unreliable. R.
A Fully Mechanized Method for the Manufacture of Cheddar Cheese

Summary A fully mechanized new method for the manufacture of Cheddar cheese, based on rapid drainage of curds in a special rotary drum, formation of large curd block, pressed hydraulically in the absence of surface whey, and automatic milling, salting, and hooping, is presented. This method, called Ched-O-Matic, has undergone extensive and large scale research investigation. The finished cheese has become fully acceptable to the trade. A matured cheese has a flavor typical of good Cheddar and displays a firm, waxy body and texture showing a few mechanical holes. The latter characteristic, if not excessive, is a desirable trait of natural Cheddar cheese. Advantages in the method lie in its easy lineflow principles of materials passing through automatic machinery. Total personnel can be reduced and peak intensity of remaining labor can be coordinated so that handling of materials is less laborious. Cheese-making is shortened by almost 1 hr. , saved mainly during salting and hooping, and a more favorable environment is created for the cutting of unit costs. In addition, easier and more effective control over product quality and sanitation are possible with the Ched-OMatic method.
WHAT IS PROPORTIONAL REASONING?

Almost all mathematics educators consider proportional reasoning as one of the most important components of middle school mathematics curriculum. It is a necessity for success not only in further mathematics topics but also in other areas of knowledge. Although its importance is commonly accepted, there is not a consensus on what proportional reasoning is. This study is based on two inspirers; the first one is the need for a crystal clear definition of proportional reasoning and the second one is the necessity for using the same terms by referring the same phenomena in order to make progress in a research area. The aim of this content analysis is to investigate proportional reasoning research articles published in five prominent mathematics education journals between the years 2007-2016. These articles were investigated in two respects; whether a definition of proportional reasoning is given or not and how proportional reasoning is defined. The results indicated that in some research articles no definition of proportional reasoning was given, some of them mentioned about only the importance of it, and others defined it as a skill, knowledge of rate and ratio, or a kind of reasoning.
Spatial organization of the North Island Brown Kiwi Apteryx australis mantelli: sex, pairing status and territoriality

In Waitangi State Forest, 51 North Island Brown Kiwi Apteryx australis mantelli were tagged with radio transmitters and observed for an average of 2.3 months. All females and the majority of males were paired and maintained territories of 6.7 and 5.5 ha, respectively. Territories overlapped widely between partners but only narrowly with those of paired neighbours. Unpaired males had territories of 12.8 ha and extensively overlapped those of paired males. Territories were maintained by long distance calls and rare aggressive encounters. Males were more territorial than females. Within pairs, males called 1.5 times more often than females and initiated most pair calls. 60% of female calls were responses to their mates. Observers could often induce aggressive behaviour (calling, fast approach) in male kiwi (by playback, for example) but hardly ever in females. Kiwi territoriality cannot be explained by the distribution and availability of food and shelter sites, but seems to serve mainly a reproductive function.
CAR-T Cell Therapies: An Overview of Clinical Studies Supporting Their Approved Use against Acute Lymphoblastic Leukemia and Large B-Cell Lymphomas

Chimeric Antigen Receptor (CAR)-T cell therapy is an exciting development in the field of cancer immunology, wherein immune T-cells from patients are collected, engineered to create ‘CAR’-T cells, and infused back into the same patient. Currently, two CAR-T-cell-based therapies, Tisagenlecleucel and Axicabtagene ciloleucel, are approved by FDA for the treatment of hematological malignancies, acute lymphoblastic leukemia and large B-cell lymphomas. Their approval has been a culmination of several phase I and II clinical studies, which are the subject of discussion in this review article. Over the years, CAR-T cells have evolved to be significantly more persistent in patients’ blood, resulting in a much-improved clinical response and disease remission. This is particularly significant given that the target patient populations of these therapies are those with relapsed and refractory disease who have often progressed on multiple therapies. Despite the promising clinical results, there are still several challenges that need to be addressed. Of particular note are the associated toxicities exemplified by cytokine release syndrome (CRS) and the neurotoxicity. CRS has been addressed by an FDA-approved therapy of its own—tocilizumab. This article focuses on the progress related to CAR-T therapy: the pertinent clinical studies and their major findings, their associated adverse effects, and future perspective.
Simulation of Shape Memory Alloy (SMA)-Bias Spring Actuation for Self-Shaping Architecture: Investigation of Parametric Sensitivity

Parametric complexity of the thermomechanical shape memory alloy (SMA) model is one of the major barriers to advanced application of the SMA actuation in adaptive architecture. This article seeks to provide architectural practitioners with decision-making information about SMA actuator design parameters. Simulation-based global sensitivity analysis of an SMA-bias spring actuation model reveals that the SMA spring index (a spring’s outer diameter divided by its wire diameter) and stiffness of the bias spring are significant factors in both displacement and force exertion. Among all parameters, maximum output stroke and force largely depend on the temperature range at which the SMA spring operates. These findings also indicate a trade-off between the spring diameter and wire thickness, demonstrating that the output stroke and force tend to counter one another. Appropriate preloading and choice of an optimal spring index should be considered for desirable SMA motion.
Efficiency of a novel gametocide amidosulfuron on rapeseed (Brassica napus)

The efficiency of a novel gametocide amidosulfuron, 1-(4, 6-dimeth-oxypyrimidin- 2-yl) -3-mesyl (methyl) sulfamoylurea, was evaluated on rapeseed (Brassica napus L.). Double application of 0.09-0.12 g/ha amidosulfuron at the uni-nucleate stage of longest buds and 12 days later, made 97.4-100% plants male-sterile in seventeen out of 20 cultivars tested. The shrunken anthers could not release pollen or produced only dysfunctional pollen grains that could not be stained by aceto carmine. The treatment also caused 10-30% reduction on seed setting in comparison to the controls. The purity of hybrid seed from crosses of'C161 x Huaye' and 'Zhongshuang No.2 x Huaye' based on amidosulfuron was 99.8% and 100.0%, respectively. The results suggested that amidosulfuron is an eflicient gametocide for B. napus.
HSV-1-Specific IgG3 Titers Correlate with Brain Cortical Thinning in Individuals with Mild Cognitive Impairment and Alzheimer’s Disease

Repeated reactivations of latent herpes simplex virus type-1 (HSV-1) in the central nervous system (CNS) may contribute to neurodegeneration in Alzheimer’s disease (AD) patients. Immune response is a key element for the control of viral reactivation. HSV-1 uses a number of strategies to evade immune recognition, Immunoglobulin G 3 (IgG3) alone counteracts humoral immunoevasion, as it is the only IgG subclass that is not blocked by the HSV-1 Fc receptor, a protein that protects virion and infected cells from antibody-mediated effector mechanisms. We examined HSV-1-specific IgG3 titers in serum of AD (n = 70) and mild cognitive impairment (MCI) (n = 61) subjects comparing the results to those of 67 age- and sex-matched healthy controls (HC); associations between MRI-determined brain cortical health and HSV-1-specific IgG3 were analyzed in a subgroup of AD and MCI subjects. HSV-1-specific IgG3 were more frequently detected in MCI compared to AD and HC subjects. Significant inverse correlations were found between IgG3 titers and brain cortical thickness in areas typically involved in dementia and HSV-1 encephalitis in AD patients; interestingly, this negative correlation was much less important in MCI subjects. All together these results suggest that in AD an inefficient IgG3 humoral immune response, failing to block viral replication, contributes to progressive neurodegeneration.