Miracle-dz/UniFAR-FTUs huggingface dataset:
Studies on pre-harvest application of nutrients on yield, quality and shelf life of mango cv. Dashehari

The experiment was conducted on mango cv. Dashehari in Horticulture Research Centre, Patharchatta, G.B. Pant Univesity of Agriculture and Technology, Pantnagar. The experiment involved the pre-harvest foliar spray of nutrients at ‘marvel stage’ of mango fruits. The treatments include CaCl2 @ 1.2 per cent, Borax @ 0.5 per cent K2SO4 @ 0.5, Ca(NO3)2 @ 1.0 per cent, ZnSO4 @ 0.5 per cent, ZnCl2 @ 0.3 per cent and control. The results obtained indicated that the fruits treated with 0.5% borax showed maximum fruit yield, fruit weight, fruit volume, T.S. S. reducing sugar, non reducing sugar and ascorbic acid content. However, the minimum physiological loss in weight was reported in 1.0% CaN(O3)2 upto the end of 12th day.
Therapy of aphasia

Impairment of language function (aphasia) is one of the most common neurological symptoms. It affects approximately a third of all stroke patients and may also be caused by other neurological disorders, such as traumatic brain injury and brain tumors. Anecdotal observations suggest that spontaneous improvement of language function is common, but usually it is neither universal nor complete. Consequently, therapy interventions that minimize the impact of aphasia on patients and their families are required, and treatment is often needed for long periods of time. Although the mainstay of the rehabilitation of aphasia remains speech and language therapy (which has many aspects), adjunctive drug treatment has also been proposed. In this article, the assessment and treatment of aphasia is reviewed and the rationale for using dopaminergic and other drugs in conjunction with speech and language therapy in the treatment of this disorder is discussed.
A DNA barcode examination of the red algal family Dumontiaceae in Canadian waters reveals substantial cryptic species diversity. 1. The foliose Dilsea - Neodilsea complex and Weeksia

The field of DNA barcoding is working towards generating a genetic system for the quick and accurate identification of eukaryotic species. For the more systematic minded, however, DNA barcoding offers a new approach towards screening and uniting large numbers of biological specimens in genetic groups as a first step towards assigning them to species and genera in an approach best termed “molecular-assisted alpha taxonomy”. This approach is particularly amenable in organisms with simple morphologies, a propensity for convergence, extensive phenotypic plasticity, and life histories with an alternation of heteromorphic generations. It is hard to imagine a group of organisms better defined by all of these traits than the marine macroalgae. In an effort to assess the utility of the DNA barcode (COI-5′) for testing the current concepts of biodiversity of marine macroalgae in Canada, a study to assess species diversity in the red algal family, Dumontiaceae, was initiated. Through this work I confirm the presence.
Interferon- Activates Multiple STAT Proteins and Upregulates Proliferation-Associated IL-2R, c-myc, and pim-1 Genes in Human T Cells

Interferon- (IFN-) is a pleiotropic cytokine that has antiviral, antiproliferative, and immunoregulatory functions. There is increasing evidence that IFN- has an important role in T-cell biology. We have analyzed the expression of IL-2R , c-myc, and pim-1 genes in anti-CD3–activated human T lymphocytes. The induction of these genes is associated with interleukin-2 (IL-2)–induced T-cell proliferation. Treatment of T lymphocytes with IFN-, IL-2, IL-12, and IL-15 upregulated IL-2R , c-myc, and pim-1 gene expression. IFN- also sensitized T cells to IL-2–induced proliferation, further suggesting that IFN- may be involved in the regulation of T-cell mitogenesis. When we analyzed the nature of STAT proteins capable of binding to IL-2R , pim-1 , and IRF-1 GAS elements after cytokine stimulation, we observed IFN-–induced binding of STAT1, STAT3, and STAT4, but not STAT5 to all of these elements. Yet, IFN- was able to activate binding of STAT5 to the high-affinity IFP53 GAS site. IFN- enhanced tyrosine phosphorylation of STAT1, STAT3, STAT4, STAT5a, and STAT5b. IL-12 induced STAT4 and IL-2 and IL-15 induced STAT5 binding to the GAS elements. Taken together, our results suggest that IFN-, IL-2, IL-12, and IL-15 have overlapping activities on human T cells. These findings thus emphasize the importance of IFN- as a T-cell regulatory cytokine.
Comportamento de variedades de alface na semeadura de março no município de Areia-PB

The lettuce (Lactuca sativa L.) is the most important hardwood in vegetable diet of the Brazilian population, due to its nutritional value and is consumed mainly in the form of salad. This study aimed to evaluate the performance of eight varieties of lettuce in the Brejo conditions in Paraiba. Soil samples were collected in the 0-20 cm topsoil of the experimental area for physical. Composite samples were collected from the compost pile for analysis of chemical and fertility. The foundation of fertilization was performed uniformly across the floor area, applying a dose of 40,000 L.ha-1, seven days before transplanting. The seeds for the production of seedlings were purchased in the local market, which are produced in a greenhouse environment and sown in trays (128 cells) using only organic compound as a substrate. The conformation adopted spacing for plants in the field was quiconica spaced 35x35 cm. We used randomized block design with eight treatments of lettuce cultivars in four replications, totaling 32 experimental units. The varieties Rainha de Maio, Crespa Grand Rapids TBR and Americana delicia, have adapted to the environmental conditions of Brejo microregion and was recommended for cultivation in the region. Cultivars Simpson, Mimosa Rubi, Romana de Paris, Regina de Verao and Baba de Verao did not show favorable agronomic characteristics according to the conditions of the study.
Differential expression of Rel/NF-κB and octamer factors is a hallmark of the generation and maturation of dendritic cells

A key feature of maturation of dendritic cells is the down-regulation of antigen-processing and up-regulation of immunostimulatory capacities. To study the differential expression of transcription factors in this process, we investigated the nuclear translocation and DNA binding of Rel/NF-κB and octamer factors during in vitro generation and maturation of dendritic cells compared with macrophage development. RelB was the only factor strongly up-regulated during the generation of both immature dendritic cells and macrophages. Cytokine-induced maturation of dendritic cells resulted in an increase in nuclear RelB, p50, p52, and especially c-Rel, whereas cytokine-treated macrophages responded poorly. This up-regulation of NF-κB factors did not correlate with lower levels of cytosolic NF-κB inhibitors, the IκBs. One IκB, Bcl-3, was strongly expressed only in mature dendritic cells. Furthermore, generation and maturation of dendritic cells led to a continuous down-regulation of the octamer factor Oct-2, whereas monocytes and macrophages displayed high Oct-2 levels. A similar pattern of maturation-induced changes in transcription factor levels was found in cultured murine epidermal Langerhans cells, suggesting a general physiological significance of these findings. Finally, this pattern of differential activation of Rel and octamer factors appears to be suitable in determining the maturation stage of dendritic cells generated by treatment with different cytokine combinations in vitro. (Blood. 2000;95:277-285)
Desempeño productivo y propiedades de la canal en ovinos Pelibuey y sus cruzas con Suffolk o Dorset

To assess the effect of genotype and sex on productive performance, carcass yield and tissue composition, 60 lambs (initial body weight 17.2±3 kg) were allotted to six treatments in a completely randomized design, using a 2 x 3 factorial arrangement, with 2 sexes: female and male, and 3 genotypes: Pelibuey (Pb), Pb*Suffolk (PbxS) and Pelibuey*Dorset (PbxD), having 10 experimental units per treatment. After 5±0.3 months in a feed lot, with body weight averaging 39.5±1.2 kg in females and 45.7±0.9 kg in males, to evaluate carcass and tissue composition four randomly selected animals per treatment were slaughtered. Average daily weight gain was greater in males (203±24 g d-1) than in females (147±17 g d-1). Crossbred males gained 18.2 % more body weight than Pb males while crossbreds females gained 27.8 % more than Pb (P 0.05) in both commercial and real carcass yield by sex or genotype effect. No differences (P>0.05) were observed in muscle content between genotypes, but muscle content was higher in males (62.2±1.2 %) than in females (57.3±3.1 %). No differences were detected in bone content but fat content was lower in the Pb group (12.8 %) than in crossbreds (14.3 %) (P<0-05).
Potential use of cholinesterase activity from tropical green mussel, Perna viridis as a biomarker in effect-based marine monitoring in Indonesia

Green mussels (Perna viridis) play an important economic and ecological role in the coastal areas of Indonesia. P. viridis has been used as an eco-sentinel organism for marine biomonitoring program in Asia regions. To magnify its competency as a relevant organism in biomonitoring, the cholinesterases of P. viridis from a selected coastal area of Indonesia have been charac- terized. Dissected organs which were gill, foot, mantle and posterior adductor muscle were examined for substrate specificity and inhibitors sensitivity using selective and non-selective substrates and inhibitors. The highest level of cholinesterase activity was observed in gill and followed by foot, mantle and posterior adductor muscle. The substrate specificity approach using vari- ous alkylthiocholines indicated that the cholinesterases of P. viridis constitute an acetylcholinesterase (AChE) and a butyryl- cholinesterase (BuChE). Likewise, the inhibitors sensitivity approach using eserine, BW284C51, and iso-OMPA sustained the previous approach which recorded typical AChE and atypical BuChE. The application of cholinesterase activity in three selected areas of Indonesian waters suggested that the gill of P. viridis is the most suitable organ for employing the ChE activity as a bio- marker in effect-based marine monitoring.
Le pecore e il lupo: indagine sul punto di vista degli allevatori nella provincia di Pisa

RIASSUNTO La presente indagine ha come obiettivo quello di mettere a fuoco la percezione del lupo da parte degli allevatori della Val di Cecina, raccogliere suggerimenti riguardo alle possibili soluzioni, valutare il livello di conoscenza e il giudizio degli allevatori sulla normativa vigente. Il lupo è percepito come un problema dall’86,3% dei soggetti intervistati, che gli attribuiscono la responsabilità degli eventi di predazione nel 91% degli episodi riportati, nonostante che questa sia stata accertata solo nel 31% dei casi. Il 72,6% degli intervistati ha dichiarato di non conoscere l’attuale legge regionale sulla tutela del patrimonio zootecnico soggetto a predazione; tuttavia, il 61,9% di essi ritiene opportuno rivederla. Solo il 28,6% degli intervistati ritiene opportuno sostenere finanziariamente la messa in opera di misure difensive antilupo. Il 42,9% dei soggetti ritiene necessario catturare i lupi presenti e traslocarli in aree non interessate da attività zootecniche, mentre il 49,2% si è espresso a favore dell’abbattimento del lupo, ritenuto frutto di interventi di immissione. La denuncia degli attacchi, laddove non solo non comporta un risarcimento adeguato ma addirittura una perdita economica per l’allevatore, non viene più effettuata, con conseguente difficoltà di monitoraggio del reale impatto del fenomeno. La partecipazione attiva, l’informazione sui metodi di prevenzione e la sensibilizzazione delle popolazioni locali, unitamente ad una maggior attenzione da parte del legislatore, rappresentano presupposti fondamentali per garantire la tolleranza e l’accettazione del predatore e per l’attenuazione del conflitto tra lupo e zootecnia. La figura del medico veterinario gioca un ruolo essenziale per la divulgazione delle informazioni necessarie.
Bacteriology and Antimicrobial Susceptibility Patterns of Childhood Acute Bacterial Conjunctivitis in Western Greece

Acute bacterial conjunctivitis is a common, highly contagious infection in children and is usually treated empirically with broad spectrum topical antibiotics. In the current study we investigated bacteriology and antibiotic susceptibility patterns in childhood acute bacterial conjunctivitis in Western Greece. We conducted a retrospective analysis of presumed acute bacterial conjunctivitis cases in ''Karamandaneio'' Pediatric General Hospital of Patras, Western Greece, between February 1, 2013 and January 31, 2018. Specimens from the lower conjunctiva fornix were isolated from 191 cases and outcomes were analyzed to identify the pathogenic bacteria of acute bacterial conjunctivitis and their corresponding antibiotic susceptibility patterns. Patients were divided into 3 groups; Group A included neonates under 28 days of life, Group B children from 1 month to 2 years and Group C from 2 years to 14 years. Results revealed that Staphylococcus spp. , Haemophilus spp. and Streptococcus spp. were the most prevalent pathogens. No significant differences in isolated pathogens were found between the age groups. Antibiotic resistance rates were higher against ampicillin, ceftriaxone, ceftazidime and sulfamethoxazole. Resistance rates to Ciprofloxacin were low while none of the evaluated isolates were resistant to vancomycin. We concluded that predominant pathogens of childhood acute bacterial conjunctivitis in Western Greece were Staphylococcus spp. , Haemophilus spp. and Streptococcus spp. Continuous surveillance, focused in distinct geographic areas, is encouraged to prepare more precise protocols of empirical treatment.
Frailty Predicts an Increased Risk of End-Stage Renal Disease with Risk Competition by Mortality among 165,461 Diabetic Kidney Disease Patients

To examine the effect of frailty on diabetic kidney disease patients’ risk of progression to end-stage renal disease (ESRD), mortality, and adverse episodes, as whether frailty modifies their risk of developing ESRD and other adverse outcomes remains unclear. We identified 165,461 DKD patients from the Longitudinal Cohort of Diabetes Patients in Taiwan (n=840,000) between 2004 and 2010, classifying them into those without frailty or with 1, 2 and ≥3 frailty components based on a modified version of FRAIL scale. Using Cox proportional hazard regression analysis, we examined the long-term risk of developing ESRD along with their risk of mortality, supplemented by a competing risk analysis against mortality. Among all participants, 66.2% (n=109,586), 27.2% (n=44,986), 5.9% (n=9,799), and 0.7% (n=1090) patients did not have or had 1, 2, and ≥3 frailty components, respectively. After a 4.1-year follow-up, 4.2% patients developed ESRD and 18.5% died. Cox proportional hazard modeling revealed that patients with 1, 2, and ≥3 frailty components had increased risks of developing ESRD (for 1, 2, and ≥3 components, hazard ratio [HR] 1.13, 1.18, and 1.2, respectively) and mortality (HR 1.25, 1.41, and 1.34, respectively), with. 9% and 16% risk elevations for ESRD and mortality per component increase. Competing risk analysis showed that frailty-induced ESRD risk was attenuated partially by mortality in those with moderate frailty. The receipt of palliative care did not attenuate this risk. Frailty increased the risk of ESRD based on a dose-response relationship among DKD patients with risk competition by mortality.
Relationship Between Legal Blindness and Depression

The higher prevalence rates of depression in visually-impaired individuals than the general population indicates that the condition per se increases the risk of depression. A person that is aware of the progressive loss of visual acuteness may have feelings of insecurity, anxiety, loss of independence and changes in social functioning, leading to depression. Several studies assessing the association between depressive symptoms and severity of vision loss have yielded inconsistent results. Some do not show any association, whereas others reported that depression severity is higher in those with substantial vision loss. The general aim of this manuscript was to determine the prevalence of depression in patients diagnosed with legal blindness in the Eye Care Service at the Hospital Córdoba between June 2016 and June 2017. The study sample consisted of 41 patients. The level of depression was assessed using the Zung scale and the degree of dependence in daily life activities was defined using the Barthel index. Data was anonymized for inclusion in a computer database and statistical confidentiality was protected. Data was analyzed using InfoStat statistical software. The results revealed a relation between legal blindness, degrees of dependency and depressive symptoms in patients of the Eye Care Service of the Hospital Córdoba. It is very important for health professionals to be trained to detect early signs and symptoms of depression and have the necessary tools for such an approach.
Pharmaceutical care in a long-stay psychiatric hospital

Objectives The aim of this study was to evaluate implementation of services provided by a clinical pharmacist for long-term-hospitalised patients with schizophrenia in a pharmaceutical-care-naive developing country. Method This was a prospective, healthcare-system, interventional, ‘before-and-after’ study. Long-term (≥6 months) inpatients with schizophrenia were included. A clinical pharmacist reviewed the full patient notes, identified drug-related problems (DRPs), and proposed interventions using a DRP Registration Form (PCNE classification V6.2). Acceptance rate and outcomes of interventions were assessed. Results For 49 patients, 71 DRPs were identified, ranging from one to four problems/patient (1.43±0.68), predominantly related to tolerability and treatment effectiveness. The DRPs were mostly caused (N=184) by inappropriate drug selection (64%) or dose (23.4%): too many drugs for indication (N=33); a non-cost-effective choice (N=29); inappropriate combination (N=27); an inappropriate drug (N=23); lack of therapeutic drug monitoring (N=14); subtherapeutic (N=13) or supratherapeutic (N=11) dosing. Excessive treatment duration was observed for 14 DRPs. The clinical pharmacist proposed 182 interventions (70% at the drug level): discontinuation of medication (N=58); dosage change (N=35); other interventions (monitoring) (N=35); a change of drug (N=18) or instructions for use (N=9); and/or introduction of a new drug (N=7). Physicians accepted 91 interventions and refused 36. Finally, 38 DRPs were solved (25 completely and 13 partially), for 25 a solution was either not needed or not possible, and, for eight, the outcome was not known. Conclusions The study underlines the high potential for pharmaceutical care to improve prescribing practices in developing countries without shared pharmacist–physician decision-making.
SPECIAL CONSIDERATIONS IN THE MANAGEMENT OF HIV/HCV COINFECTION

Liver disease has emerged as a major cause of morbidity and mortality in patients infected with the human immunodeficiency virus (HIV). The introduction of pegylated interferon α (PEGIFN α) and ribavirin (RBV) combination therapy has greatly improved treatment options for patients coinfected with HIV/hepatitis C virus (HCV). However, management of HCV in HIV coinfected patients is complicated by the myelosuppressive effects of anti-HCV therapy, potential hepatotoxicity of antiretroviral therapy, and accelerated progression of liver fibrosis. Patient selection, timing of anti-HCV therapy, and evaluation of the potential drug interactions between HCV and antiretroviral therapy are important factors in the management of HCV infection in this patient population. Current evidence from large randomized studies of PEG-IFN α plus RBV indicates that coinfected patients should be treated earlier in the course of HCV infection, and the duration of therapy should potentially be longer to maximize the likelihood of sustained virologic response. Several questions remain regarding optimal timing of treatment, length of treatment, and the role of HIV/HCV virus-specific interactions on prognosis and response to treatment. (Adv Stud Med. 2005;5(4C):S356-S360) C hronic infection with hepatitis C virus (HCV) has become a leading cause of morbidity and mortality among patients infected with human immunodeficiency virus (HIV)-1 and a major challenge in the management of such patients. In the United States, approximately 25% of HIV-infected patients are also infected with HCV. 1 Although the natural progression of HCV-related hepatic fibrosis is relatively slow in monoinfected patients, interaction between HIV and HCV viruses accelerates progression of HCV liver disease, particularly in patients with advanced stages of immunodeficiency. 2,3
EVALUATION OF THE CORRELATION OF DIFFERENT METHODS IN DETERMINING SKELETAL MATURATION UTILIZING CERVICAL VERTEBRAE IN LATERAL CEPHALOGRAM

Introduction: It is necessary to evaluate skeletal maturation in functional orthodontic treatments. The most common method for determining skeletal maturation is made upon assessing hand-wrist radiographs. Recently, different methods use cervical vertebrae on lateral cephalogram to determine skeletal maturation. The aim of this study was to evaluate the correlation between different methods of assessing skeletal maturation using cervical vertebrae and to compare them with hand-wrist radiograph. Materials & Methods: In this descriptive-analytical study, hand-wrist radiographs and lateral cephalograms in NHP were obtained from for 47 patients aged from 10 to 15 whom were admitted to the department of orthodontics of Mashhad dental school. On hand-wrist radiographs, skeletal maturation was assessed by means of TW3 method. Cervical vertebrae maturation was evaluated on lateral cephalogram using the methods described by Lamparski, Mito, Roman and Hassel & Farman. Correlation coefficient was determined between skeletal maturation values based on cervical vertebrae and hand-wrist radiographs by Pearson and Spearman analysis. Results: Correlation coefficient between cervical vertebral age (using Lamparski, s method) and skeletal age(using TW3 method) was 0.81. For Mito, s, Roman, s and Hassel & Farman, s methods the correlation coefficient was 0.80, 0.997 and 0.995 respectively. No significant correlation was revealed between cervical vertebral bone age (using Mito, s & Lamparski, s methods) in 10-13 year old boys and that of hand-wrist base (P>0.05). Conclusion: In all groups using, Roman, s and Hassel & Farman, s methods had a high correlation between cervical vertebrae and hand-wrist skeletal maturation. So, these two methods can be used as relable alternatives for hand-wrist radiograph in skeletal maturation evaluation. Key words: Skeletal maturation, hand-wrist radiograph, lateral cepharogram, cervical vertebrae.