Miracle-dz/UniFAR-FTUs huggingface dataset:
Diagnosis of Bovine Digital Dermatitis: Exploring the Usefulness of Indirect ELISA

The precision by which animal diseases are diagnosed affects our ability to make informed decisions with regards to animal health management, from a clinical and economic perspective. Lameness is a major health condition in dairy cattle. The underlying causes of lameness include bovine digital dermatitis (BDD), which is reported as one of the main causes of infectious lameness in dairy cattle. Presently, the gold standard for BDD diagnosis in dairy cattle is visual inspection of lifted hooves—a labour intensive and subjective method. Research has suggested that Treponema spp. are the main pathogens associated with the establishment of BDD. We explored the potential of indirect enzyme-linked immunosorbent assay (ELISA) as a diagnostic serological tool in the identification of cows at different stages of BDD. Additionally, we evaluated the predictive power of this diagnostic tool on the future occurrence of BDD lesions. A total of 232 cows from three farms were used in the study. Serum samples and hoof health data were collected at three time points: ~ 30 days pre-calving, around calving, and approximately 30 days post-calving. The mean absorbance from the ELISA test was compared across different clinical presentations of BDD as assessed by visual inspection of the hooves according to the M-stage classification system. A transition model was developed to estimate the probability of lesion occurrence in time t + 1 based on the spectrophotometer (absorbance) reading in time t. The mean absorbance reading for both IgG1 and IgG2 anti-Treponema antibodies was associated with disease presence—apart from M4.1 lesions, animals with no lesions had a lower mean when compared to animals with lesions regardless of the score. Additionally, the mean absorbance reading of animals with active lesions was higher when compared to animals with no lesions. However, the anti-Treponema antibody assays failed to identify disease presence in a consistent manner. Moreover, indirect ELISA readings were not a predictor of the future occurrence of BDD lesions. In conclusion, although the levels anti-Treponema antibodies were associated with disease presence, the ELISA test failed to detect disease unequivocally and had no predictive value in the future occurrence of BDD lesions.
Influence of Emojis on Online Trust Among College Students

Emojis are increasingly used in online communication and expression, however, most previous studies have focused on describing this phenomenon, but less on how it affects interpersonal trust relationships. Therefore, this study examines the effect of emojis on online interpersonal trust among college students through three experiments. A total of 62 college students were recruited for Experiment 1. The results demonstrated that positive emoji () improved the level of trust of trustors in the trust game [t(60) = –2.79, p = 0.007], whereas that of the control group exerted no effect on the initial level of online trust among college students. Then, 74 college students were selected for Experiment 2. The results indicated no significant differences between the experiment and control groups in terms of the influence of negative emojis () on initial online trust using. A joint analysis (via ANOVA) of Experiments 1 and 2 illustrated that the type of emoji exerted a significant effect [F(2,96) = 3.96, p = 0.02, η2 = 0.08] on college students’ online trust. Finally, we recruited 111 participants for Experiment 3 to explore the role of emojis on online trust among acquaintances. The results suggested that the individual propensity to trust plays a moderate role in the relationship between emojis and online trust among acquaintances. That is, emojis influenced interpersonal trust among acquaintances only if the level of propensity to trust, is low.
Low Serum Testosterone Concentrations Are Associated With Poor Cognitive Performance in Older Men but Not Women

Objective: Current evidence on the association between serum testosterone and cognitive performance has been inconsistent, especially in older adults. To investigate the associations between serum testosterone and cognitive performance in a nationally representative sample of older men and women. Methods: We used data from the National Health and Nutrition Examination Survey (NHANES) 2011–2014. 1,303 men and 1,349 women aged 60 years or older were included in the study. Serum total testosterone was preformed via isotope dilution liquid chromatography tandem mass spectrometry (ID-LC-MS/MS) method. Free testosterone was calculated by Vermeulen’s formula. Cognitive performance was evaluated by the Consortium to Establish a Registry for Alzheimer’s Disease (CERAD) test, Animal Fluency test, and Digit Symbol Substitution Test (DSST). Binary logistic regression and restricted cubic spline models were applied to evaluate the association of testosterone and cognitive performance. Results: In men, higher concentrations of total testosterone were associated with better performance on CERAD test (OR = 0.51; 95%CI = 0.27–0.95) and DSST (OR = 0.54; 95%CI = 0.30–0.99) in adjusted group. Similarly, higher concentrations of free testosterone were associated with better performance on CERAD test (OR = 0.32; 95%CI = 0.17–0.61) and DSST (OR = 0.41; 95%CI = 0.17–0.96) in men. These associations were not seen in women. Conclusion: Serum testosterone concentrations were inversely associated with cognitive performance in older men but not women in the United States.
Integrating Oceanographic Data and Benthic Community Structure Temporal Series to Assess the Dynamics of a Marginal Reef

Reefs are the richest marine ecosystems. Their benthic communities generate structural complexity and participate in nutrient cycles, providing habitat and food for many marine species. These ecosystems have been threatened by local and global anthropogenic impacts and changes in community structure have led to loss of biodiversity, ecosystem function and services worldwide. Most studies about these structural changes have been conducted in Caribbean and Indo-Pacific coral reefs. In the Southwestern Atlantic, where reefs are naturally algae-dominated, these efforts are incipient, especially at oceanic islands where local anthropic impacts tend to be lower, and natural and climate-induced fluctuations might be easily detected. We conducted the first temporal assessment of benthic communities and the influence of oceanographic parameters between 2013 and 2019 in Fernando de Noronha (FNA), the largest Brazilian oceanic archipelago. We annually sampled benthic communities in FNA’s shallow reefs (2–21 m) using photoquadrats, quantified and gathered organisms in major groups according to their functional roles. We also characterized and tested “sea surface temperature,” “marine heatwaves,” “diffuse attenuation coefficient,” and “wave energy” influence for the same period. The most abundant groups were epilithic algal matrix (EAM; mean annual coverage: 23–60%), macroalgae (15–35%) and calcifiers (15–29%), followed by cyanobacteria (1–37%), suspension/filter-feeders (<2%), zoanthids (<1%) and other invertebrates (<0.1%). EAM was negatively correlated with “marine heatwaves” and positively correlated with “wave energy,” while macroalgae and calcifiers showed opposite responses to “marine heatwaves” and “wave energy,” respectively. Cyanobacteria was positively correlated with “marine heatwaves. ” The dominance of EAM and macroalgae was already described for reefs along the Brazilian Province and we demonstrated the persistence of this structure over the years in FNA, with the exception of 2019 when there was a substantial increase of cyanobacteria after a strong marine heatwave. Our results suggest a flickering dynamic between EAM and macroalgae, which vary according to the oceanographic conditions, reinforcing its distinct dynamics from most tropical coral reefs. However, the increase of cyanobacteria added to projections of more frequent and stronger marine heatwaves worldwide indicate possible structural changes in this community. Continued monitoring of community and oceanographic drivers is key for better understanding and predicting changes in important marginal reefs.
The Role of HLA Antigens and Steroid Dose on the Course of COVID-19 of Patients After Kidney Transplantation

Background: Kidney transplant recipients appear to be at higher risk for critical COVID-19. Our analysis aimed to identify the possible risk factors for a severe course of the COVID-19 disease and to determine the influence of selected human leukocyte antigens (HLAs) on the course of the disease. Methods: This is a retrospective, multicenter analysis that included patients that were confirmed to be severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) positive after kidney transplantation (KT). The group of patients was divided into two subgroups according to the course of the infection, as follows: non-hospitalized and hospitalized. Results: A total of 186 patients (men, 69.4%) with confirmed SARS-CoV-2 positivity were included in the group. The following independent risk factors for the outcome of hospitalization were identified: the age at the time of infection [odds ratio (OR) = 1.19, P < 0.0001], a body mass index (BMI) >29.9 kg/m2 (OR = 7.21, P < 0.0001), <7.5-mg prednisone dose/day (OR = 2.29, P = 0.0008), and HLA-DQ2 with a protective nature (OR = 0.05, P = 0.0034). Conclusions: Higher doses of corticosteroids (>7.5 mg/kg) in standard immunosuppressive regimes and HLA-DQ2 appear to be protective factors in our analysis.
The Role of Perceived Organizational Support in Mental Health of Healthcare Workers During the COVID-19 Pandemic: A Cross-Sectional Study

Background: Data support the link between the coronavirus disease 2019 (COVID-19) pandemic and mental distress in healthcare workers (HCWs). Although previous studies have documented the association between organizational policies and employees' psychological and mental status, there is still scant evidence regarding the effect of perceived organizational support (POS) on mental distress in HCWs during the pandemic. Aims: The present study aimed to assess the association between POS and mental distress in HCWs during the COVID-19 pandemic. The role of POS in stress, depressive and trauma symptoms in HCWs was investigated. Methods: This was an online cross-sectional study in 424 HCWs. Data were collected during the first wave of the pandemic, and included demographics, a 7-item questionnaire assessing POS, the “Patient Health Questionnaire” assessing depressive symptoms, the “Impact of Events Scale Revised,” measuring post-traumatic stress disorder (PTSD) symptoms and the “Perceived Stress Scale” assessing perceived stress. Results: The mean POS score was 3.33 [standard deviation:1.85; range 0–7]. Younger (p < 0.001), less experienced (p < 0.001), female (p = 0.002), and non-physician HCWs (p = 0.031) were more likely to report lower self-perceived organizational support than older, male, more experienced physicians. Self-perceived organizational support was significantly and negatively associated with and self-assessed intensity of stress, depressive and traumatic symptoms, after adjusting for putative confounders (p < 0.001). Discussion: Self-perceived organizational support was significantly associated with HCWs' self-assessed mental status during the pandemic. Organizational support and mental distress should be addressed simultaneously in HCWs during the COVID-19 pandemic to increase resilience among them.
Dapagliflozin has No Protective Effect on Experimental Pulmonary Arterial Hypertension and Pulmonary Trunk Banding Rat Models

Sodium-glucose cotransporter-2 (SGLT2) inhibitors, a novel class of hypoglycemic drugs, show excellent cardiovascular benefits, and have further improved heart failure outcomes, significantly reducing cardiovascular and all-cause mortality irrespective of diabetes status. However, the efficacy of SGLT2 inhibitors in pulmonary arterial hypertension (PAH) and right ventricular (RV) dysfunction remains unknown. This study aimed to evaluate the effects of dapagliflozin in rats with PAH and RV dysfunction. PAH was induced in rats by monocrotaline (MCT) subcutaneous injection (60 mg/kg). Isolated RV dysfunction was induced in another group of rats by pulmonary trunk banding (PTB). Dapagliflozin (1.5 mg/kg) was administered daily via oral gavage one day (prevention groups) or two weeks (reversal groups) after modeling. Echocardiography and hemodynamic assessments were used to observe pulmonary vascular resistance and RV function. Histological staining was used to observe pulmonary vascular and RV remodeling. As compared with MCT group, dapagliflozin treatment did not significantly improve the survival of rats. Pulmonary arterial media wall thickness in MCT group was significantly increased, but dapagliflozin did not significantly improved vascular remodeling both in the prevention group and reversal group. In MCT group, RV hypertrophy index, RV area, the fibrosis of RV increased significantly, and RV function decreased significantly. Consistently, dapagliflozin did not show protective effect on the RV remodeling and function. In the PTB model, we also did not find the direct effect of dapagliflozin on the RV. This is a negative therapeutic experiment, suggesting human trials with dapagliflozin for PAH or RV failure should be cautious.
Determinants of Recent HIV Self-Testing Uptake Among Men Who Have Sex With Men in Jiangsu Province, China: An Online Cross-Sectional Survey

Background: To help inform regarding HIV self-testing (HIVST) upscale, we assessed the determinants of recent HIVST uptake among men who have sex with men (MSM) in Jiangsu province, China. Methods: We conducted a convenience online survey from March to April, 2020 among men aged ≥16 years, who had ever had sex with other men. Statistical analysis included Pearson's chi-square test, bivariate correlation, and multivariable logistic regression. p < 0.05 was considered statistically significant. Results: Of the total 692 participants, 69.5% (481) were aged between 18 and 40 years, and 65.9% (456) had reportedly ever self-tested. Using HIVST for first HIV test (aOR = 1.98, 95% CI: 1.21–3.26), perceiving HIVST as more private (aOR = 1.41, 95% CI: 0.85–2.35), and users not needing to go to a health facility (aOR = 1.68, 95% CI: 1.20–2.34) were associated with recent HIVST as facilitating factors. Conclusion: HIVST uptake rate has increased among Jiangsu MSM and can be further promoted by healthcare workers routinely recommending HIVST to their clients.
Staying “One Step Ahead of a Racist”: Expanding Understandings of the Experiences of the Covid-19 Pandemic Among People From Minoritized Ethnic Groups Living in Britain

Covid-19 has had a disproportionate impact on those in minoritized ethnic groups. Considerable attention has been given to evidence of ethnic inequalities in rates of infection, hospitalisation, and death. But other ways in which the pandemic experience has been affected by ethnicity have received less consideration. This paper explores the lived experiences of people in different minoritized ethnic groups living in South West England, during the United Kingdom’s first pandemic lockdown, using qualitative data collected from interviews and comments provided on a survey. Perceived positive opportunities for growth were offset by anxiety and stress, which were themselves compounded by an awareness of the additional risks they experienced as members of racialised groups, and a sense that this was being ignored—or intentionally exacerbated—by the British authorities. Frustration with an incompetent and corrupt national Government was intensified by concerns regarding their racist motives. Racism in wider society undermined confidence in key public institutions, such as the NHS and the police, while also producing barriers to informal local-community pandemic responses. Only through recognition of the particular ways in which the pandemic affected those in minoritized ethnic groups, including the multiple and compounding effects of current and historical racism, will it be possible to identify avenues for transformative systemic policy change and opportunities to rebuild trust and a better post-pandemic society for all.
Assessment of pharmacists’ perception toward continuing education

Continuing education (CE) is a structured educational activity. Pharmacists must actively participate in CE and is an important part of developing the professional competency of pharmacists. This research focuses on measuring Saudi pharmacists' perception in CE, its impact on professional performance, and the barriers in CE. This was a cross-sectional study, conducted in 2020, using random sample of Saudi pharmacists working in all workplaces from different cities in Saudi Arabia using a questionnaire. The questionnaire consists of 15 questions that assess the perception of Saudi pharmacists toward CE and barriers that prevent them from CE. A total of 409 pharmacists participated in the study. Majority of pharmacists were working in government hospitals (48.4%) and have <2 years of practice experience (44.5%). More than 70% of respondents acknowledged that CE helps to increase their knowledge. The pharmacists mentioned that getting a certificate (23.37%) was the major reason for attending a CE event. The reasons that prevent respondents from attending live CE were cost and work responsibilities (23.59% and 24.57%, respectively). This study reported a subjective assessment of pharmacists' perception toward CE, their lifelong learning experience. Saudi pharmacists showed a great desire for CE because they believed that it greatly affects their professional performance.
Can I trust my ears in VR? Literature review of head-related transfer functions and valuation methods with descriptive attributes in virtual reality

In this article, we present the current state of the art in binaural audio with the focus on head-related transfer functions (HRTFs) and valuation methods of virtual acoustics with descriptive attributes. This combination provides a methodology, which delivers the basis for research studies in virtual reality (VR) on individual and non-individual head-related transfer functions. Based on the largely explored localization perception of static audio signals, this review offers an overview of the directional hearing during head and sound source movement and multimodality in audiovisual virtual environments. Perceptual quality characteristics provide evaluation methods from which future HRTF VR experiments and virtual environments studies on binaural acoustics could benefit.
CIES e-Working Paper N.o 230/2020 Social Media disinformation in the pre-electoral period in Portugal

Since the North American presidential election of 2016, the role of social media on the propagation of misleading news and its instrumentalization by partisan groups has raised concerns. In this article we analyse the contents of 47 Facebook pages and 39 Facebook groups prior to the Portuguese parliamentary election of 6th of October of 2019 to track disinformation. Groups and pages to monitor were selected through a process that combined the number of fans or members, the proportion of political content, and the number of posts per week. We concluded that disinformative content was prevalent in the pages and groups monitored, that several political actors had a relevant influence on the debate and that most disinformation stemmed from the spinning of both mainstream and non-mainstream news to serve a political purpose.
IDENTIFICATION AND ANTIFUNGAL SUSCEPTIBILITY TESTING FOR INFECTED PATIENTS WITH CANDIDA SPECIES USING THE BIOMERIEUX VITEK 2 SYSTEM

Background: Candidiasis is a disease caused by genus Candida, it is more serious in the immunocompromised patients with leukemia, lymphoma, renal failure, autoimmune diseases. Candidiasis diagnosed by many tests like culturing, VITEK identifying and VITEK Antifungal susceptibility testing. These tests assist in the diagnosis and choosing the effective antifungal treatment for the infected patients. Objective: To identify the antifungal susceptibility for Candida species in immunocompromised patients from samples collected at Baghdad Teaching Hospital in the Medical City, Iraq. Patients and Methods: This is a cross-sectional study carried out on (38) patients, (28 female and 10 male), They were critically ill with suspected fungal infection and a positive sputum or blood culture for Candida referred by the attending physicians from units of ( Hemato-oncology department, internal medicine wards, respiratory care unit, out patients, cardiac intensive care, surgical unit, Emergency department and urogenital unit ). Results: By using VITEK 2 system, YST identification the report of identification for (38) patients was Candida albicans (26.31 % ), Candida ciferrii (15.78% ) while for Candida dublinensis (13.15%), whereas (7.89 %) Candida tropicalis and Candida parapsilosis, Beside that (5.26%) Candida lipolytica, Candida famata and Candida lusitaniae, otherwise (2.36%) Candida rugosa and Candida krusei, other yeasts appear (5.26%) Cryptococcus laurentii, and (2.63%) Rhodotorula glutinis / mucilaginosa, Cryptococcus neoformans, and Saprochaete capitata, Meanwhile( 15.78 %) were unidentified organism. Regarding the antifungal drug sensitivity test, the antifungal susceptibility test report showed Candida albicans, Candida tropicalis, Candida parapsilosis, Candida famata were sensitive to all six drugs (Amphotericine B, Caspofungin, Fluconazole, Flucytosine, Micafungin, Voriconazole), Although Candida ciferrii was sensitive to ( FLU,VRC,MCF, AB,FCT) with unknown result to (CAS), Whereas Candida dublinensis was sensitive to all six drug except one isolate resistant to (FCT), Beside that Candida lipolytica was sensitive to (FLU,VRC,MCF,AB), intermediate to (FCT) with unknown result to (CAS), Meanwhile Candida lusitaniae was sensitive to ( VRC,AB, FCT) and other isolate was resistant to (AB) with unknown result to(FLU,CAS,MCF), Besdide that Candida rugosa was sensitive to (VRC,AB) and intermediate (FCT) with unknown result to (FLU,CAS, MCF), Although Candida krusei was resistant to (CAS,AB,FCT) with unknown result to (FLU, VRC, MCF), The other yeast Rhodotorula glutinis, Rhodotorula mucilaginosa, Cryptococcus neoformans, Cryptococcus laurnettii was sensitive to(AB) and unknown result to other drugs, Meanwhile Saprochaete capitata was sensitive to (FLU,MCF,AB) with unknown result to (VRC, CAS, FCT) Meanwhile Unidentified organisms were sensitive to all six drugs except one isolate was resistant to (CAS,MCF,FCT) and intermediate to (FLU ).