Miracle-dz/UniFAR-FTUs huggingface dataset:
Early Adverse Events and Immune Response Following Second and Third COVID-19 Vaccination in Pregnancy

(1) Background: The adverse-effect profile and short-term obstetric and neonatal outcomes among pregnant women who were vaccinated with the BNT162b2 vaccine at any stage of pregnancy do not indicate any safety concerns. The vaccine is effective in generating a humoral immune response in pregnant women. (2) Objective: To determine the vaccine-induced immunity and adverse events associated with the third (booster) dose of the BNT162b2 vaccine compared to the first and second dose of the vaccine among pregnant women. (3) Study design: A prospective cohort study in a tertiary referral center comparing pregnant women who were vaccinated by the first and second dose of the BNT162b2 (Pfizer/BioNTech) vaccine to pregnant women vaccinated by a third (booster) dose, between January and November 2021. A digital questionnaire regarding adverse events was filled by both groups 2–4 weeks after vaccination. Blood samples were collected and tested for SARS-COV-2 IgG antibodies 28–32 days after the administration of the second or third BNT162b2 dose. (4) Results: Seventy-eight pregnant women who received the first and second doses of the vaccine were compared to eighty-four pregnant women who received the third dose of the vaccine. In terms of adverse events following vaccination, local rash/pain/swelling (93.6% vs. 72.6%, p < 0.001) was significantly less common after the third vaccination compared to after the second vaccination. Other adverse events, including early obstetric complications, did not differ between the two groups. SARS-CoV-2 IgG serum levels 28–32 days after the vaccination were significantly higher after the third vaccination compared to the second vaccination (1333.75 vs. 2177.93, respectively, p < 0.001). (5) Conclusion: This study confirms the safety regarding early adverse events and immunogenicity, and the lack of early obstetric complications of the BNT162b2 second- and third-dose vaccine in pregnant women. The third (booster) dose is effective in generating a stronger humoral immune response in pregnant women compared with the second dose.
Automatic Classification of Pavement Distress Using 3D Ground-Penetrating Radar and Deep Convolutional Neural Network

The realization of nondestructive detection and classification of pavement distress is of great significance for putting forward a reasonable maintenance scheme and prolonging the service life of the road. In this paper, the advanced air-coupled 3D ground-penetrating radar (3D-GPR) was used to detect Li-Ma Expressway (Jiangsu Province, China) to achieve the purpose of rapid, accurate, and nondestructive testing. Through on-site coring at the corresponding radar anomaly signal, it is verified that the 3D-GPR can identify the characteristics of pavement distress. To address the issue of a large amount of 3D-GPR images required to be processed and low efficiency of current manual classification, VGG16 and ResNet50 models were established based on deep convolutional neural network to classify four pavement distresses automatically. The results showed that the maximum accuracy, precision, and recall obtained from the VGG16 model training results were 98.73%, 97.98%, and 96.17%, respectively. In addition, The overall processing time of VGG16 to identify 2525 radar images with $200 \times 200$ pixels is 232 s. And VGG16 was selected as the automatic classification model of 3D-GPR image for pavement distress of Li-Ma Expressway.
A Hybrid Model Integrating MPSE and IGNN for Events Recognition Along Submarine Cables

The vibration signal is essential for accurate event recognition along submarine cables. However, rapid and concise identification still poses challenges for prompt recognition and classification of events in harsh environments. For such reasons, this article proposes a developed hybrid model combining the modern power spectrum estimation (MPSE) and improved gradient neural networks (IGNNs), to identify and organize events instantaneously. Three different categories of data are selected as data samples, collected using the phase-sensitive optical time-domain reflectometry ( $\Phi $ -OTDR) device. The signal characteristics of the power distribution are extracted in the frequency and time domains. These characteristics together form the eigenvector, used in a multiclass IGNN classifier, to initiate the extent and position of collision events on the cable. The results demonstrate that the proposed hybrid model has a better identification rate, compared to the existing schemes used for the same purposes. It is verified that the accuracy rate of identification has expanded by almost 1%; confirming the validity and reliability of the proposed hybrid model.
Field Emission from Carbon Nanostructures

Field emission electron sources in vacuum electronics are largely considered to achieve faster response, higher efficiency and lower energy consumption in comparison with conventional thermionic emitters. Carbon nanotubes had a leading role in renewing attention to field emission technologies in the early 1990s, due to their exceptional electron emitting properties enabled by their large aspect ratio, high electrical conductivity, and thermal and chemical stability. In the last decade, the search for improved emitters has been extended to several carbon nanostructures, comprising carbon nanotubes, either individual or films, diamond structures, graphitic materials, graphene, etc. Here, we review the main results in the development of carbon-based field emitters.
Breaking the Silence: Therapeutic Uses of Music and the Wellbeing of Adolescents

The author of this review paper critically discusses the Handbook of Music, Adoles­cents, and Wellbeing, edited by Katrina McFerran, Philippa Derrington, and Suvi Saarikallio (2019). The purpose of this paper is to evaluate the strengths and limi­tations of the volume, which, drawing upon empirical, practical, theoretical, and personal perspectives from the fields of music therapy, music psychology, music cognition, and music sociology, explores the therapeutic role of music in the lives of adolescents. Moreover, an attempt is made to highlight the most valuable obser­vations and learnings which a non-clinician might glean from the book in light of the COVID-19 pandemic. The author hopes that future collections on music, ado­lescence, and wellbeing will rebalance their research towards more cultural, socio-economic, and musical diversity to ensure that marginalised voices are heard.
Electrostatic fields in a dusty Martian environment

While there have been several studies suggesting the possibility of electrical activity on Mars, to date there have been no measurements to search for evidence of such activity. In the absence of widespread water clouds and convective storm systems similar to those on the Earth and Jupiter, the most likely candidate for the creation of electrostatic charges and fields is triboelectric charging of dust, i.e., the friction between blown dust and the ground, and of dust particles with each other. Terrestrial experience demonstrates that electric fields 5 to 15 kV-m(exp -1) are not uncommon in dust storms and dust devils in desert regions, where the polarity varies according to the chemical composition and grain size. Simple laboratory experiments have demonstrated that modest electrostatic fields of roughly 5,000 V-m(exp -1) may be produced, along with electrical spark discharges and glow discharges, in a simulation of a dusty, turbulent Martian surface environment. While the Viking landers operated for several years with no apparent deleterious effects from electrostatic charging, this may have been at least partly due to good engineering design utilizing pre-1976 electronic circuitry to minimize the possibility of differential charging among the various system components. However, free roaming rovers, astronauts, and airborne probes may conceivably encounter an environment where electrostatic charging is a frequent occurrence, either by way of induction from a static electric field or friction with the dusty surface and atmosphere. This raises the possibility of spark discharges or current surges when subsequent contact is made with other pieces of electrical equipment, and the possibility of damage to modern microelectronic circuitry. Measurements of electrostatic fields on the surface of Mars could therefore be valuable for assessing this danger. Electric field measurements could also be useful for detecting natural discharges that originate in dust storms. This detection could be performed at distances ranging from 10s of km in the case of J-charge-like discharge signatures, to planetary distances if there exists a global electrical circuit or Schumann resonance spectrum.
Prediction Model for Hypertension and Diabetes Mellitus Using Korean Public Health Examination Data (2002–2017)

Hypertension and diabetes mellitus are major chronic diseases that are important factors in the management of cardiovascular disease. In order to prevent the occurrence of chronic diseases, proper health management through periodic health check-ups is necessary. The purpose of this study is to determine the incidence of hypertension and diabetes mellitus according to the health check-up, and to develop a predictive model for hypertension and diabetes according to the health check-up. We used the National Health Insurance Corporation database of Korea and checked whether hypertension or diabetes occurred from that date according to the number of health check-ups over the past 10 years. Compared to those who underwent five health check-ups, those who participated in the first screening had hypertension (OR = 2.18, 95% CI = 2.14–2.22), diabetes mellitus (OR = 1.33, 95% CI = 1.30–1.35) and both diseases (OR = 2.46, 95% CI = 2.39–2.53); individuals who underwent 10 screenings had hypertension (OR = 0.86, 95% CI = 0.83–0.88), diabetes mellitus (OR = 0.83, 95% CI = 0.81–0.85) and both diseases (OR = 0.83, 95% CI = 0.79–0.87). Individuals who attended fewer than five screenings compared with individuals who attended five or more screenings had hypertension (OR = 1.61, 95% CI = 1.59–1.62; AUC = 0.66), diabetes mellitus (OR = 1.21, 95% CI = 1.20–1.22; AUC = 0.59) and both diseases (OR = 1.75, 95% CI = 1.72–1.78, AUC = 0.63). The machine learning-based prediction model using XGBoost showed higher performance in all datasets than the conventional logistic regression model in predicting hypertension (accuracy, 0.828 vs. 0.628; F1-score, 0.800 vs. 0.633; AUC, 828 vs. 0.630), diabetes mellitus (accuracy, 0.707 vs. 0.575; F1-score, 0.663 vs. 0.576; AUC, 0.710 vs. 0.575) and both diseases (accuracy, 0.950 vs. 0.612; F1-score, 0.950 vs. 0.614; AUC, 0.952 vs. 0.612). It was found that health check-up had a great influence on the occurrence of hypertension and diabetes, and screening frequency was more important than other factors in the variable importances.
Black and Latinx Primary Caregiver Considerations for Developing and Implementing a Machine Learning–Based Model for Detecting Child Abuse and Neglect With Implications for Racial Bias Reduction: Qualitative Interview Study With Primary Caregivers

Background Child abuse and neglect, once viewed as a social problem, is now an epidemic. Moreover, health providers agree that existing stereotypes may link racial and social class issues to child abuse. The broad adoption of electronic health records (EHRs) in clinical settings offers a new avenue for addressing this epidemic. To reduce racial bias and improve the development, implementation, and outcomes of machine learning (ML)–based models that use EHR data, it is crucial to involve marginalized members of the community in the process. Objective This study elicited Black and Latinx primary caregivers' viewpoints regarding child abuse and neglect while living in underserved communities to highlight considerations for designing an ML-based model for detecting child abuse and neglect in emergency departments (EDs) with implications for racial bias reduction and future interventions. Methods We conducted a qualitative study using in-depth interviews with 20 Black and Latinx primary caregivers whose children were cared for at a single pediatric tertiary-care ED to gain insights about child abuse and neglect and their experiences with health providers. Results Three central themes were developed in the coding process: (1) primary caregivers’ perspectives on the definition of child abuse and neglect, (2) primary caregivers’ experiences with health providers and medical documentation, and (3) primary caregivers’ perceptions of child protective services. Conclusions Our findings highlight essential considerations from primary caregivers for developing an ML-based model for detecting child abuse and neglect in ED settings. This includes how to define child abuse and neglect from a primary caregiver lens. Miscommunication between patients and health providers can potentially lead to a misdiagnosis, and therefore, have a negative impact on medical documentation. Additionally, the outcome and application of the ML-based models for detecting abuse and neglect may cause additional harm than expected to the community. Further research is needed to validate these findings and integrate them into creating an ML-based model.
Welding Fume Instillation in Isolated Perfused Mouse Lungs—Effects of Zinc- and Copper-Containing Welding Fumes

Zinc- and copper-containing welding fumes can cause systemic inflammation after exposure in humans. Recent ex vivo studies have shown that the observed inflammation originates from exposed immune cells. In vitro studies identified the soluble fraction of metal particles as the main effectors. Isolated perfused mouse lungs (IPLs) were perfused and ventilated for 270 min. Lungs were instilled with saline solution (control), welding fume particle suspension (WFs) or the soluble fraction of the welding fumes (SF-WFs). Bronchoalveolar lavage fluid (BALF) and perfusate samples were analyzed for cytokine levels and lung tissue mRNA expression levels were analyzed via RT-PCR. All lungs instilled with WFs did not complete the experiments due to a fatal reduction in tidal volume. Accordingly, IL-6 and MPO levels were significantly higher in BALF of WF lungs compared to the control. IL-6 and MPO mRNA expression levels were also increased for WFs. Lungs instilled with SF-WFs only showed mild reactions in tidal volume, with BALF and mRNA expression levels not significantly differing from the control. Zinc- and copper-containing welding fume particles adversely affect IPLs when instilled, as evidenced by the fatal loss in tidal volume and increased cytokine expression and secretion. The effects are mainly caused by the particles, not by the soluble fraction.
Finite Element Analysis of Ship Deck Sandwich Panel

Recently various types of sandwich panel are applied for constructing bridge and ship structures. Sandwich panel is material that consists of lightweight core material and two metal faceplates. The application of sandwich panel in ship structures makes the structure less-complex and ship’s selfweight lighter because of the reduction of secondary stiffeners. This paper discusses sandwich panel that was fabricated using synthetic resin core material and two steel faceplates. This study is aimed to analyze stresses developed in the sandwich panel of 750 GT Ro-Ro ship car deck structure when it was subjected to the deck design load. The finite element analysis was carried out to obtain the stress distribution and maximum deformation on the car deck structures. The stress of the ship car deck constructed using conventional steel structure, i.e. steel plate and stiffener, was compared with the stress of the deck that was built using sandwich panel.
Cerebrospinal fluid level of neurofilament light chain is associated with increased disease activity in neuro-Behçet’s disease

Background/aim Clinical exacerbations characterized with neurological symptoms are observed in around 10% of Behçet’s disease (BD) patients and may culminate in severe disability. Although certain immunological factors have been associated with disease activity in neuro-Behçet’s disease (NBD), biomarkers for monitoring the clinical outcome of NBD have not been properly investigated. Materials and methods Levels of neurofilament light chain (NFL), homeobox protein Hox-B3 (HoxB3), and YKL-40 were measured in cerebrospinal fluid (CSF) samples of 23 parenchymal (n = 16) and nonparenchymal (n = 7) NBD patients obtained during NBD attacks by ELISA. Parameters of clinical progression and outcome were assessed for an average follow-up period of 3.9 ± 1.3 years. Results Parenchymal NBD patients showed elevated CSF levels of NFL, HoxB3, and YKL-40 as compared to nonparenchymal patients. NBD patients showing an increase in modified Rankin score (mRS) values during follow-up had significantly higher CSF NFL levels. Patients with relatively lower CSF NFL levels (<1000 ng/L) did not develop attacks or cognitive impairment interfering with daily life activities during follow-up. NFL levels correlated with disease duration and mRS at the last follow-up visit, while HoxB3 levels correlated with a number of attacks during follow-up. Conclusion CSF level of NFL appears to predict the prospective somatic and cognitive disability in NBD patients and may thus be potentially used as a biomarker of clinical outcome in this disease.
Delayed asymptomatic blunt traumatic diaphragmatic hernia: an unusual case report

IntroductionTraumatic diaphragmatic hernia (TDH) is uncommon, being encountered in around 0.8%-8% of patients with blunt abdominal trauma. Severe comorbidities such as fractures and thoraco-abdominal or head injuries that accompany TDH, are responsible for poor prognosis and often mask diaphragmatic injury itself. Objective of this case report was to highlight rare blunt TDH case to avoid missed diagnosis leading to complications. Case descriptionSixty seven-year old man presenting with right chest pain without difficulty of breathing after falling from stairs 1 hour before hospital admission. On clinical examination, vitals were stable, but with decreased breath sounds on right lower side of chest. Patient had history of trauma from being crushed by elevator 40 years ago without any proven diaphragmatic injury. Initial erect chest X-ray findings were inhomogeneous opacity shadow on lower right hemithorax suspected to be diaphragmatic hernia and 7th right rib fracture with pleural effusion. Thorax CT scan showed herniated right lobe of liver, gall bladder, and mesenteric fat on right hemithorax causing displacement of mediastinal structures. Patient was diagnosed with delayed TDH and hemothorax caused by newly fractured rib. Patient was referred to a better-equipped facility due to the limited surgical facilities in referring hospital. ConclusionDelayed TDHs are not common, but can lead to serious consequences. Blunt TDH occurs more often on left than on right side, in ratio of approximately 3:1. Traumatic diaphragmatic hernia is sometimes diagnosed many years after traumatic event due to latent phase of disease possibly ranging from days to years.
Treatment of Prolactinoma

Prolactinomas are the commonest form of pituitary neuroendocrine tumor (PitNET), representing approximately half of such tumors. Dopamine agonists (DAs) have traditionally been the primary treatment for the majority of prolactinomas, with surgery considered the second line. The aim of this review is to examine the historical and modern management of prolactinomas, including medical therapy with DAs, transsphenoidal surgery, and multimodality therapy for the treatment of aggressive prolactinomas and metastatic PitNETs, with an emphasis on the efficacy, safety, and future directions of current therapeutic modalities. DAs have been the mainstay of prolactinoma management since the 1970s, initially with bromocriptine and more recently with cabergoline. Cabergoline normalizes prolactin in up to 85% of patients and causes tumor shrinkage in up to 80%. Primary surgical resection of microprolactinomas and enclosed macroprolactinomas performed by experienced pituitary neurosurgeons have similar remission rates to cabergoline. Aggressive prolactinomas and metastatic PitNETS should receive multimodality therapy including high dose cabergoline, surgery, radiation therapy (preferably using stereotactic radiosurgery where suitable), and temozolomide. DAs remain a reliable mode of therapy for most prolactinomas but results from transsphenoidal surgery in expert hands have improved considerably over the last one to two decades. Surgery should be strongly considered as primary therapy, particularly in the setting of microprolactinomas, non-invasive macroprolactinomas, or prior to attempting pregnancy, and has an important role in the management of DA resistant and aggressive prolactinomas.
In Vitro Antioxidant and Antiaging Activities of Collagen and Its Hydrolysate from Mackerel Scad Skin (Decapterus macarellus)

The skin of mackerel scad fish (Decapterus macarellus) is a new source for pepsin-soluble collagen and its hydrolysate, both of which have never been explored. This study aims to characterize and determine the in vitro antioxidant, antiglycation, and antityrosinase activity of pepsin-soluble collagen (PSC) and hydrolyzed collagen (HC) from mackerel scad skin. PSC was extracted using 0.5 M acetic acid containing 0.1% pepsin for 48 h at 4 °C. The obtained PSC was then hydrolyzed with collagenase type II (6250 U/g) to produce HC. The PSC yield obtained was 6.39 ± 0.97%, with a pH of 6.76 ± 0.18, while the HC yield was 96% from PSC. SDS-PAGE and Fourier Transform Infrared (FTIR) analysis showed the typical features of type I collagen. HC demonstrated high solubility (66.75–100%) throughout the entire pH range (1–10). The PSC and HC from mackerel scad skin showed antioxidant activity against 2,2-diphenyl-1-picrylhydrazyl (DPPH), with IC50 values of 148.55 ± 3.14 ppm and 34.966 ± 0.518 ppm, respectively. In the antiglycation test, PSC had an IC50 value of 239.29 ± 15.67 ppm, while HC had an IC50 of 68.43 ± 0.44 ppm. PSC also exhibited antityrosinase activity, with IC50 values of 234.66 ± 0.185 ppm (on the L-DOPA substrate), while HC had an IC50 value of 79.35 ± 0.5 ppm. Taken together, these results suggest that the skin of mackerel scad fish has potential antiaging properties and can be further developed for pharmaceutical and cosmetic purposes.
Modelling the cost‐effectiveness of pulse oximetry in primary care management of acute respiratory infection in rural northern Thailand

We aimed to determine the cost‐effectiveness of supplementing standard care with pulse oximetry among children <5 years with acute respiratory infection (ARI) presenting to 32 primary care units in a rural district (total population 241,436) of Chiang Rai province, Thailand, and to assess the economic effects of extending pulse oximetry to older patients with ARI in this setting.
Phantom study of radiotracer concentration quantification in breast scintigraphy

We are developing a breast imaging system that combines digital x-ray mammography and gamma emission scintigraphy in an integrated unit. Here we present results of a phantom study designed to investigate the use of lesion position information from the x-ray images to improve quantification of lesion and background radioactivity concentrations. The preliminary results indicate that the effects of gamma ray attenuation, partial volume averaging, and scatter on lesion image contrast can be modeled.