Miracle-dz/UniFAR-FTUs huggingface dataset:
Cowpeas and Sunflower Seed Meal - Available Sources of Methionine for Organic Poultry Diets

Citation: Annie King. , et al. “Cowpeas and Sunflower Seed Meal Available Sources of Methionine for Organic Poultry Diets". EC Agriculture 6.3 (2020): 01-09. Abstract As organic poultry commands larger shares of markets, consumers, producers, and regulatory agencies seek ways to provide dietary methionine, required in production of essential protein for growth. Poultry producers continue to advocate for the use of synthetic methionine in traditional and organic poultry diets as alternative sources of this amino acid are not yet readily available at low cost. Raising broilers on organic pasture or raising slow-growing broiler genotypes with choice feeding are alternatives for niche markets. Other possibilities of methionine-rich feed ingredients for fast growing broilers include algae, probiotics, insects at various stages of development, fishmeal, poultry byproduct meal, pea protein, rapeseed, rapeseed expeller, rice protein, various types of beans/peas, and sunflower seed meal. Two of these possible poultry feed ingredients, cowpeas and sunflower seed meal, are presently available for use on a large commercial scale. These feed ingredients are grown in many parts of the world. Feed formulation show that they, along with reduced amounts of soy and corn, can be used to create organic starter, grower, starter, and finisher diets without added methionine.
Time Series Analysis of Stock Market Volatility in Pakistan

DOI: 10.9734/AJPAS/2020/v6i430166 Editor(s): (1) Dr. Oguntunde, Pelumi Emmanuel, Department of Mathematics, College of Science and Technology, Covenant University, Ota, Ogun State, Nigeria. Reviewers: (1) Lydie Myriam Marcelle Amelot, University of Mauritius, Mauritius. (2) David Adugh Kuhe, Federal University of Agriculture, Makurdi, Nigeria. Complete Peer review History: http://www.sdiarticle4. com/review-history/54416
A GENERAL FIXED POINT THEOREM FOR A PAIR OF MAPPINGS IN PARTIAL METRIC SPACES

In this paper a general fixed point theorem for a pair of mappings satisfying a new type of implicit relation, different than the type from [8], which generalize the results from Theorem 3.5 [4], Theorem 4.5 [4], Theorem 2.3 [2], Corollary 2.4 [2], Corollary 2.8 [2] and other results from [1] is proved. 2010 Mathematics Subject Classification: 54H25, 47H10.
The use of email and text message prompts to engage users of a digital intervention

Background Digital interventions (DIs) provide effective and potentially cost-effective models for improving health behaviour outcomes as they deliver health information and services that are widely disseminated, confidential, and can be tailored to needs of the individual user. DIs have been used successfully for different health behaviours such as smoking cessation and increasing physical activity. However, their effectiveness is limited by low usage rates, with non-engagement a major challenge. Engagement can potentially be optimised through the use of context-specific prompts such as emails and text messages. Aim To inform, develop and assess the potential of using email and text message as prompts to optimise users’ engagement with a DI called HeLP-Diabetes (Healthy Living for People with Diabetes). Context HeLP-Diabetes is a DI targeting self-management for people living with Type 2 diabetes. It aims to provide its users with the tools and support to improve and maintain their health and well-being. Methods The following series of studies with their corresponding objectives were conducted: • A systematic review and meta-analyses to determine the range and effectiveness of technology based engagement prompts, and to identify characteristics of prompts to test in subsequent studies. • Developing, piloting and testing prompts, within the context of HeLP-Diabetes using the Medical Research Council guidance for complex intervention, to identify the methodological and practical challenges of developing engagement prompts and integrating them with HeLP-Diabetes. • A mixed method study to identify the characteristics of prompts, specifically the content and delivery mode, that have the potential to promote engagement with HeLP-Diabetes. The mixed method study used quantitative data from HeLP-Diabetes usage data, and qualitative data from think aloud interviews exploring prompt content with a selected group of users. • Two consecutive randomised controlled trials comparing different prompt content and delivery modes in order to assess the potential impact of prompts on engagement with HeLP-Diabetes and to test the procedures of the pilot trial to identify any potential challenges for future trials.
Nuclear Engineering and Design

Fluid flows through rod bundles are observed in many nuclear applications, such as in the core of Gen IV liquid metal fast breeder nuclear reactors (LMFBR). One of the main features of this configuration is the appearance of flow fluctuations in the rod gaps due to the velocity difference in the sub-channels between the rods. On one side, these pulsations are beneficial as they enhance the heat exchange between the rods and the fluid. On the other side, the fluid pulsations might induce vibrations of the flexible fuel rods, a mechanism generally referred to as Flow Induced Vibrations (FIV). Over time, this might result in mechanical fatigue of the rods and rod fretting, which eventually can compromise their structural integrity. Within the SESAME framework, a joint work between Delft University of Technology (TU Delft), Ghent University (UGent), and NRG has been carried out with the aim of performing experimental measurements of FIV in a 7-rods bundle and validate numerical simulations against the obtained experimental data. The experiments performed by TU Delft consisted of a gravity-driven flow through a 7-rods, hexagonal bundle with a pitch-to-diameter ratio = P/D 1.11. A section of 200mm of the central rod was made out of silicone, of which 100mm were flexible. Flow measurements have been carried out with Laser Doppler Anemometry (LDA) whereas a high-speed camera has measured the vibrations induced on the silicone rod. The numerical simulations made use of the Unsteady Reynolds-averaged Navier-Stokes equations (URANS) approach for the turbulence modelling, and of strongly coupled algorithms for the solution of the fluid-structure interaction (FSI) problems. The measured frequency of the flow pulsations, as well as the mean rod displacement and vibration frequency, have been used to carry out the benchmark.
Effect of lactic acid bacteria on Listeria monocytogenes infection and innate immunity in rabbits

The present study aimed to investigate the effect of probiotic lactic acid bacteria (LAB) addition on Listeria monocytogenes translocation and its toxin listeriolysin O (LLO), proinflammatory factors, immune organ indexes and serum immunoglobulins in farmed rabbits. Five treatments included negative control (NC), positive control (PC) with L. monocytogenes infection and supplemental LAB at 3.0 × 106 (low-LAB, L-LAB), 3.0 × 108 (medium-LAB, M-LAB) and 3.0 × 1010 (high-LAB, H-LAB) CFU/kg of diet, respectively. The LAB was a mixture of equal amounts of Lactobacillus acidophilus (ACCC11073), Lactobacillus plantarum (CICC21863) and Enterococcus faecium (CICC20430). A total of 180 weaned rabbits (negative for L. monocytogenes) were randomly assigned to 5 groups with 6 replicates of 6 rabbits each in response to the 5 treatments. L. monocytogenes infection occurred on the first day of feeding trial and dietary LAB supplementation lasted for 14 days. The results showed that on days 7 and 14 post administration, L. monocytogenes in caecum, liver, spleen and lymph nodes was reduced in M-LAB and H-LAB compared to PC (P < 0.05), and linear and quadratic reducing trends were found in liver on day 7 (P ≤ 0.002). On day 14, mucosa LLO mRNA expression and serum TNFα, IL1β and IFNγ were reduced in the three LAB treatments (P < 0.05), and linear and quadratic trends were found on TNFα and IL1β (P ≤ 0.025); indexes of thymus and spleen, serum IgA and IgG were increased in the LAB treatments (P < 0.05). It is concluded that LAB can be used to alleviate L. monocytogenes infection and to improve the immune function of farmed animals.
POSSIBLE EFFECTS OF FEEDING FISH THE DRIED-TREATED SEWAGE: II- CONCERNING BLOOD PROFILE AND HISTOLOGICAL STRUCTURE OF THE LIVER

In a field study conducted for 102 days at feeding period, using a polyculture system (Nile tilapia, silver carp, common carp, and African catfish at a rate 1: 1: 1: 1) in two Hapas, one for control fish fed a commercial diet and the second one fish were fed a dried sewage sludge (DSS, product of treating sanitary and agricultural drainage of Al-Reiad, Kafr El-Sheikh, Egypt). At the end of the experiment, blood samples were withdrawn and liver samples were taken from each fish species for hematological, biochemical and histological examinations. From the obtained results, it was clear that DSS feeding did not negatively affect the blood picture in general, although the significantly elevated values of transaminases activity and triglycerides concentration. DSS feeding led to some drastic histological alterations in the liver structure. Conclusively, and because of the presence of some pollutants from agricultural and urban drainages whether in the rearing water or in the sewage sludge that can negatively affect fish health, production, and quality as well as could be inter the food chain and threat human health; so, it is recommended to give more concern on food and water quality (environmental friendly) used in aquaculture to offer safe products for human consumption.
ESTIMATION OF GENETIC PARAMETERS FOR MILK PRODUCTION TRAITS IN A HERD OF HOLSTEIN FRIESIAN CATTLE IN EGYPT

Genetic parameters for some milk production traits were estimated in a herd of Holstein Friesian (HF) cattle in Egypt. A total number of 502 lactation records of 300 HF cows sired by 29 bulls form a herd belonging to Alexandria Copenhagen Company for Dairy and Meat Production was used in the present study. Data were collected during 7 years (2005-2011) and analyzed using SAS and WOMBAT. Means of total milk yield (TMY), 305 day milk yield (305-DMY) and lactation period (LP) were 10718 kg, 8805 kg and 397 days, respectively. Parity had no significant effect on all traits, except for 305-DMY (P<0.0001). Season of calving, also, had no significant effect on all traits, except for LP (P<0.0025). Heritability estimates of TMY, 305-DMY and LP were 0.19, 0.25 and 0.15, respectively. The moderate estimate of heritability of 305 milk yield indicated that this trait could be made through selection as well as better managemental practices Repeatability of TMY, 305-DMY and LP were 0.48, 0.39 and 0.34, respectively. Positive genetic and phenotypic correlation coefficients were obtained for all traits and ranged from 0.01 to 0.77 and from 0.12 to 0.75, respectively. Results indicated possibility of genetic improvement of milk yield by selection for 305DMY only due to having higher estimate of heritability compared to TMY, and also because of its reasonably high genetic correlation coefficient with TMY.
USEFULNESS OF CD44 LEVEL AS A BIOMARKER IN DIAGNOSIS OF ACUTE LIVER REJECTION

The incidence of acute and chronic rejection has declined with improvement of immunosuppression regimens in liver transplant recipients. The CD44 protein belongs to a large family of type I Trans membrane glycoproteins and expressed on the surface of most vertebrate cells and is an important receptor for the components of extracellular matrix. The study evaluated if the serum level of CD44 had a value in diagnosis of acute rejection depending on proved rejection by liver biopsy. The patients were recruited from ASCOT from May 2017 to December 2018. They were 20 adults with Post LDLT with elevated liver function tests and were reviewed. The results showed that serum level of CD44 was significantly lower in the rejection group in our study in patient with post liver transplantation. There was highly significant difference between controls & patients as regards serum level of CD44. Negative correlation between serum levels of CD44, WBCs & AST. There was highly significant difference between patients with different pathological findings as regards serum level of CD44. The best cut off point for serum level of CD44 as a marker of rejection was found ≤ 44ng/ml with sensitivity of 85% and specificity of 95% in diagnosis of acute cellular rejection.
Towards an optimal set of initial weights for a Deep Neural Network architecture

: Modern neural network architectures are powerful models. They have been proven eﬃcient in many ﬁelds, such as imaging and acoustic. However, these neural networks involve a long-running and time-consuming process. To accelerate the training process, we propose a two-stage approach based on data analysis and focus on the gravity center concept. The neural network is ﬁrst trained on reduced data represented by a set of centroids of the original data points, and then the learned weights are used to initialize a second training phase of the neural network over the full-blown data. The design of deep neural networks is extremely diﬃcult, and the primary objective is to achieve high performance. In this study, we apply the Taguchi method to select good values for the factors required to build the proposed architecture.
Assessment of lateral femoral wall thickness as a measure to predict postoperative lateral femoral wall fractures in intertrochanteric fractures treated with Dynamic Hip Screw

Background: Intertrochanteric fracture is defined as the fracture in which the main plane of bony separation passes the tip of the greater trochanter obliquely downwards and inwards to or through the lesser trochanter. Interchanteric fractures occur in the area just distal to the capsule of the hip joint, and above the area of isthmus of the medullary canal. Dynamic Hip Screw is the gold standard in the management of intertrochanteric fractures. Aim: To investigate the reliability of lateral femoral will thickness as a measure to predict postoperative lateral femoral will fractures in AO31A1 and AO31A2 intertrochanteric fractures treated with Dynamic Hip Screw. Methods: A retrospective study was conducted. Data was collected for a period of 2 years. Intertrochanteric fractures AO31A1 and AO31A2 who were treated with dynamic Hip screw were included in the study. Results: Thirty, intertrochanteric fractures of AO31A1 and AO31A2 type were enrolled. The mean age group is 64.3 years among which mostly were males (53%). Most of the patients (60%) had fractures on the left side of which (86%) sustained injury due to trivial fall. Out of 30 cases 12 cases (40%) were AO31A1type and 18 cases (60%) were AO31A2 type. The mean thickness was 27.9mm in AO31A1 group and 21.4mm in AO31A2 group. AO31A1 (40%) and AO31A2 (43%) achieved normal radiological union within 6 months postoperatively without any lateral femoral wall fractures in the postoperative period. The lateral femoral wall thickness is significantly thin in AO31A2 group with lateral femoral wall fractures (P<0.008) when compared with those without lateral femoral wall fractures (AO31A1 and AO31A2). Conclusion: Preoperative assessment of lateral femoral wall thickness is a useful measure to predict postoperative lateral femoral wall fractures in intertrochanteric fractures treated with DHS. From this study, it is recommended that a preoperative lateral femoral wall thickness of less than 22.1 mm is the critical value below which the lateral femoral wall fracture can occur when fixed with DHS alone.
Specific Polymorphism 4G/5G Gene for PAI-1 as a Possible Cause of Cerebral Venous Thrombosis: A Case Report

Abstract Thrombosis of veins and venous sinus (CVT) is the rare cerebral vascular disorder which makes less than 1% of all strokes. Thrombosis of veins and venous sinuses is picturesquely called “мајоr neurological forger” since it is characterized by very varied clinical picture. Among the various causes of CVT, which can be of infective or non-infective nature, the congenital hyper coagulations especially stand out, diagnosis is based on highly sophisticated diagnostic tests. We present the case of a female patient, 36 years old, who was hospitalized at the Clinic for Neurology in Clinical Center because of the diffuse headache she had for the last few days, with milder right-sided hemiparesis and one generalized tonic-clonic epileptic seizure. With nuclear magnetic resonance (MR/2D venography) the thrombosis of the upper and lower sagittal sinuses is confirmed. By appropriate laboratory tests, as well as by confirmatory immunological and genetic analyses, the impact of the most of the factors is excluded which can contribute to the occurrence of venous thrombosis. The only pathological findings which indicated the possible congenital thrombophilia as the cause of the sagittal sinus thrombosis was the determination of the specific polymorphism of the 4G/5G gene for plasminogen activator inhibitor 1. According to our knowledge, this is the first decribed case of the possible impact of the specific polymorphism of the 4G/5G gene for plasminogen activator inhibitor of 1 on the development of cerebral venous thrombosis.
Intravenous sedation in dental implant surgeries: A systematic review of hemodynamic effects

Background The main objective of thissystematic review wasto identify the hemodynamic effects of intravenous sedatives used in dental implant surgeries. Methods Embase, PubMed, ProQuest, Scopus, Ovid, and Cochrane databases were searched with no limitations. Of 59 studies obtained, 50 studies were excluded due to incompatibility with the subject. The remaining studies were reviewed in full text and assessed for the risk of bias individually. The included studies were reviewed by the research team, and the necessary data were extracted. Results Four studies were finally included. Two of the studies compared local anesthesia and intravenous sedation, while the other two compared the consequences of different types of intravenous sedation. By comparing the hemodynamic effects, the systolic and diastolic blood pressure and the heart rate data were collated. Midazolam was the most frequently used intravenous sedative, and Dexmedetomidine affected hemodynamics the most. Conclusion Intravenous sedation leads to decreased heart rate and blood pressure. Better hemodynamic outcomes improve the patients’ cooperation by decreasing stress and anxiety. Dexmedetomidine seems to be the first choice for intravenous sedation.
PREPARATION DIFFERENTIAL CULTURE MEDIUM FOR CRYPTOCOCCUS NEOFORMANS FROM AQUEOUS EXTRACT OF LEAVES AND FLOWERS OF CHRYSANTHEMUM CINERARIAEFOLIUM

A new medium was prepared to isolate and diagnose the yeast Cryptococcus neoformans from flower and leaves aqueous extract of chrysanthemum. Methods Prepared differential culture medium for C. neoformans from aqueous extract of leaves and flowers of Chrysanthemum cinerariaefolium and chemical, spectral tests of the extracts were tested, in addition of gas chromatography (GC)–mass was used to diagnose phenolic compounds in both leaves and flowers. Results Showed that the yeast was grow with typical colonies on the new medium compared with other media which using in diagnosed of this yeast such as Staib agar and Sabourauds dextrose agar and unlike the yeast Candida albicans (as a negative control), which appeared in cream to white on this medium. Furthermore, the colonies are dark brown in color on flower chrysanthemum medium and light brown color on leaves chrysanthemum medium.
Percutaneous Cholecystostomy is a Reasonable Alternative for the Treatment of Acute Cholecystitis in Critically Ill Patients: a Single Center Analysis

Background / objective. Laparoscopic cholecystectomy is a safe procedure and the treatment of choice for acute cholecystitis. As an alternative treatment option in critically ill patients percutaneous cholecystostomy (PC) is performed.Methods. Retrospective review of patients who had undergone PC from 2008 to 2017 at the Department of Surgery, Hospital of Lithuanian University of Health Sciences Kaunas Clinics. Patients were reviewed for demographic features, laboratory tests, ASA class, complications, outcomes, hospital stay and mortality rate.Results. Fifty-four patients were included in the study. Forty patients (74%) were ASA III and ten patients (18.5%) – ASA IV. Statistically signi­ficant decrease in white blood cell count (from 14.26±6.61 to 8.65±5.15) and C-reactive protein level (from 226.22±106.60 to 51.91±63.70) following PC was observed. The median hospital stay was 13.06 (range 2–68) days and 30-day mortality rate 13%. There were no deaths directly related to procedure. For eleven patients (20.4%) delayed cholecystectomy was scheduled.Conclusions. PC is a reasonable treatment option for high-risk patients with acute cholecystitis and co-morbidities. It can be used as a temporizing treatment option or as a definitive treatment with a low number of delayed cholecystectomies.
Therapeutic Itinerary of the Patients Followed for Myasthenia Gravis in Dakar

Introduction: Myasthenia gravis is an autoimmune disease caused by specific autoantibodies that induce dysfunction of neuromuscular transmission. The diagnostic procedure is similar regardless of the age of the subject. As in any disease, the management starts with the diagnosis, which is often unduly delayed. The purpose of our study was to evaluate the reasons for this delay. Methodology: This was a retrospective, transversal, and descriptive study on the files of myasthenic subjects followed over a period of four years (2014 to 2017) at the neuroscience clinic of the Univresity National Center of Fann and at the consultation of neurology of the Pikine National Hospital Center where a hetero-administered questionnaire was completed. Results: The study involved 18 myasthenic patients including 13 women and 5 men with a sex ratio of 2.6. The median age of the patients was 32 years [14 - 60 years]. The average time to patient diagnosis was 24 months. The patients had consulted on average four times before the diagnosis of myasthenia gravis. The referral hospital was the facility attended by 78% of patients and the ophthalmology service was the first service consulted by 13 patients, or 72%. The median age at onset of symptoms was 28 years. Ptosis was the first symptom in 56% of the cases. Conclusion: Myasthenia gravis is a disorder little known to the public and to practitioners. The ophthalmologist was the first remedy. It would be wise for any practitioner to know the main manifestations.
Bio-conjugate Approaches for Improved Targeted Toll-like receptor based Immune Adjuvant Vaccines

iii Acknowledgements v Table of contents vii List of figures xii List of tables xiv List of schemes xv List of abbreviations xvi Chapter One Introduction 1 1.1. Cancer 2 1.1.1. Cancer treatment 3 1.2. Immune responses to cancer 3 1.2. 1. Innate immune responses 3 1.2. 2. Antigen uptake and processing 6 1.2. 3. Antigen presentation on MHC-II 8 1.2. 4. Antigen presentation on MHC-I 9 1.2. 5. Cross-presentation of antigen to MHC-I 10 1.2. 6. Acquired immune responses 14 1.2. 7. CD4 T-cells 14 1.2. 8. CD8 T-cells 16 1.2. 9. Effector T-cell function 16 1.2. 10. T-cell memory development 18 1.2. 11. Natural Killer and invariant Natural Killer T cells 19 1.2. 12. Cancer immunoediting 20 1.2. 13. Tumour antigens 21 1.3. Vaccination 22 1.4. Cancer immunotherapy 23 1.5. Vaccine adjuvants 29 1.5. 1.1. Mineral salts 32 1.5. 1.2. Monophosphoryl lipid A (MPL) 32 1.5. 1.3. Emulsions 33