Miracle-dz/UniFAR-FTUs huggingface dataset:
Brown fat-associated postprandial thermogenesis in humans: Different effects of isocaloric meals rich in carbohydrate, fat, and protein

The increase of whole-body energy expenditure seen after a single meal ingestion, referred to as diet-induced thermogenesis (DIT), substantially varies depending on the meal’s macronutrient composition. Brown adipose tissue (BAT), a site of non-shivering thermogenesis, was reported to be involved in DIT. To examine the effects of meal composition on BAT-associated DIT in humans, healthy male participants underwent fluorodeoxyglucose–positron emission tomography to assess BAT activity, and respiratory gas analysis for 2 h after ingestion of a carbohydrate-, protein-, or fat-rich meal (C-meal, P-meal, and F-meal, respectively). The calculated DIT at 2 h was 6.44 ± 2.01%, 3.49 ± 2.00%, and 2.32 ± 0.90% of the ingested energy after the P-meal, C-meal, and F-meal, respectively. The DIT after C-meal ingestion correlated positively with BAT activity (P = 0.011), and was approximately twice greater in the group with high-BAT activity than in the group with low-BAT activity (4.35 ± 1.74% vs. 2.12 ± 1.76%, P < 0.035). Conversely, the DIT after F-meal or P-meal ingestion did not correlate with BAT activity, with no difference between the two groups. Thus, BAT has a significant role in DIT after ingestion of a carbohydrate-rich meal, but hardly after ingestion either protein- or fat-rich meal.
Oral antibiotics relieve allergic asthma in post-weaning mice via reducing iNKT cells and function of ADRB2

The role of normal gut microbiota in asthma or ovalbumin (OVA)-induced asthma tolerance (OT) remains unclear. Here, we established mouse models of asthma and OT followed by 2 weeks of antibiotic treatment, to clear the gut microbiota. Antibiotic treatment was found to alleviate allergic asthma accompanied with a reduction of invariant natural killer (iNKT) cells. By RNA-seq analysis, we found that β-adrenergic receptor (ADRB) genes, including Adrb1, Adrb2, and Adrb3, were downregulated in asthmatic lungs, but these changes were reversed in OT lungs. Moreover, Adrb2 and Adrb3 were significantly upregulated in asthmatic lungs after antibiotic treatment. Surprisingly, blocking ADRB with propranolol relieved allergic asthma while reducing T helper 2 (Th2) and Treg cell numbers. Further analyses using flow cytometry and immunofluorescence showed that the protein expression level of ADRB2 was higher in asthmatic lungs than that in the control and OT lungs. Notably, dendritic cells (DCs), especially the ADRB2+ DCs, were increased in asthmatic lungs compared to that in the control and OT lungs. In addition, ADRB2+ DCs were significantly reduced following the administration of the ADRB2-specific antagonist ICI118551. Our findings suggest that antibiotic treatment can alleviate OVA-induced allergic asthma via reducing the frequency of iNKT cells and function of ADRB2.
Neuromuscular and acute symptoms responses to progressive elastic resistance exercise in patients with chronic obstructive pulmonary disease: Cross-sectional study

Background Quadriceps muscle training is a key part in the rehabilitation of chronic obstructive pulmonary disease (COPD) patients. However, exercise intensity prescription and progression with the typically used elastic bands is challenging. We aimed to evaluate neuromuscular, acute symptoms and cardiorespiratory responses (heart rate and dyspnea) during progressive elastic resistance exercise in patients with COPD. Methods Fourteen patients diagnosed with moderate-very severe COPD performed knee extensions at different elastic resistance levels (i.e., colors). The neuromuscular activity was recorded using surface electromyography for the rectus femoris, vastus lateralis and vastus medialis, together with rate of perceived exertion, perceived quadriceps fatigue, dyspnea, oxygen saturation and heart rate. Results For the vastus lateralis and rectus femoris, increase of muscle activity was evident from a two-level increment when using the red color. For the vastus medialis, there were no muscle activity progressions. Dyspnea, quadriceps fatigue and especially rate of perceived exertion increased in a dose-response fashion and were correlated with the resistance level and muscle activity at the three muscles. Conclusion Heavy elastic resistance exercise is feasible in COPD patients without excessive dyspnea and a stable cardiorespiratory response. In general, at least two elastic resistance increments are needed to enhance muscle activity for the vastus lateralis and rectus femoris, while there is no increase for the vastus medialis. These results may help to individualize exercise dosing during elastic resistance training in patients with COPD.
Environmental fate of cefquinome: Adsorption and degradation

Cefquinome (CEQ), the fourth generation of cephalosporins, has been widely used in practice for the treatment of bacterial infections due to its broad antimicrobial spectrum, stability, and stronger antibacterial activity. However, the wide use of CEQ can cause an environmental risk via animal excretion. In the current study, the environmental fate of CEQ was investigated. The migration rate of CEQ from soil to the aquatic environment was approximately 60%. The half-life (T1/2) of CEQ degradation in the water ranged from 0.96 to 13.75 d. Our results showed that the temperature, illumination, and pH had an effect on the degradation rate, and the rate of CEQ degradation was significantly accelerated under high temperatures. CEQ was more stable in acidic environments than in alkaline. E-isomer of CEQ and △3-isomer of CEQ were the major degradation metabolites identified by UPLC-Q-Orbitrap MS. The product ion m/z 293.041 was the typical fragment ion for E-isomer of CEQ, and m/z 201.044 and m/z 152.016 were the typical fragment ion for △3-isomer of CEQ. The degradation metabolites exhibited lower antibacterial activity, simultaneously, the toxicity of the E-isomer of CEQ should pay more attention to.
Laparoscopic surgery versus robot-assisted surgery for choledochal cyst excision: A systematic review and meta-analysis

The aim of this following study is to systematically review and analyze the published data comparing laparoscopic surgery and robotic assisted surgery for choledochal cyst excisions through the metrics of operative time, length of hospital stay and postoperative outcome. PubMed, Web of Science, Embase, Ovid, and the Cochrane Library databases were combed through and data was retrieved from the timespan between January 1995 and October 2021. The primary measures included operative time, intraoperative bleeding, hospital stay, and postoperative complications. Quality and risk of bias were assessed using the Newcastle-Ottawa Quality Assessment Scale. Making use of random-effects models, we pooled the odds ratios (ORs) and mean differences (MDs) with 95% confidence intervals (95% CIs). Six studies comprising a total 484 patients who had undergone either laparoscopic surgery [307 (63.43%) patients] or robot-assisted surgery [177 (36.57%) patients] were included in this analysis. Three of the articles involved adults while the other three involved children. All of the studies were published after 2018 and were retrospective case–control studies. Patients undergoing robotic surgery had a shorter hospital stay (MD, 0.95; 95% CI, 0.56 to 1.35; p < 0.00001) and a longer operative time (MD, −57.52; 95% CI, −67.17 to −47.87; p < 0.00001). And there was no significant discrepancy in complications between the two groups. Compared to laparoscopic surgery, robot-assisted surgery is associated with a shorter hospital stay, scores highly in terms of both safety and feasibility, however it also results in a longer operative time. And the two procedures have the same short- and long-term results.
Th1, Th2, and Th17 cells and their corresponding cytokines are associated with anxiety, depression, and cognitive impairment in elderly gastric cancer patients

Objective T helper (Th) cells modulate the stress response, oxidative stress, and neuroinflammation to mediate anxiety, depression, and cognitive impairment. This study intended to explore the association between Th cells and anxiety, depression, and cognitive impairment in elderly gastric cancer patients. Methods Totally, 176 elderly gastric cancer patients were enrolled in this study. Peripheral blood samples were collected. Th1, Th2, and Th17 cells were detected by flow cytometry; their corresponding cytokines were examined by ELISA. The Hospital Anxiety and Depression Scale (HADS) and Mini-Mental State Examination (MMSE) were assessed. Results In total, 42.0%, 33.0%, and 19.9% of elderly gastric cancer patients presented anxiety, depression, and cognitive impairment, respectively. Th1 (P = 0.016), Th17 (P = 0.009), and IL-17A (P = 0.001) were positively associated with the HADS-A score. Th17 (P = 0.003) and IL-17A (P = 0.009) levels were increased in patients with anxiety compared with those without anxiety. Concurrently, a positive association was observed for Th1 (P = 0.027), Th17 (P = 0.014), and IFN-γ (P = 0.049) with the HADS-D score. Th1 (P = 0.017) and Th17 (P = 0.049) levels were increased in patients with depression than in those without depression. Moreover, Th1 (P = 0.003), Th17 (P < 0.001), IFN-γ (P = 0.014), and IL-17A (P < 0.001) were inversely related to MMSE scores, but only Th17 (P < 0.001) and IL-17A (P < 0.001) were increased in patients with cognitive impairment compared with those without cognitive impairment. Conclusion Th1 and Th17 cells reflect anxiety, depression, and cognitive impairment risk to a certain extent in elderly gastric cancer patients, implying their involvement in the pathology of the abovementioned psychological and cognitive issues. However, further validation is needed.
Bloody fluids located between the temporal muscle and targeted cerebral cortex affect the establishment of indirect collaterals in Moyamoya disease with surgical bypass: A case-control study

Objective Bypass yields favorable outcomes in the treatment of Moyamoya disease (MMD). Bloody fluids accumulate between the targeted cortex and the temporal muscle after surgical bypass. These fluids are handled empirically via subcutaneous tubes or conservative treatments. However, substances located in certain positions may adversely affect the establishment of indirect collaterals (ICs) from muscular grafts. Methods Patients in our hospital from January 2014 to December 2019 were eligible for inclusion. Digital subtraction angiography (DSA) and radiological examinations were used during the perioperative and follow-up periods. Bloody fluid volumes were calculated using computed tomography- (CT-) based 3D Slicer software. The characteristics of bloody fluids, patient demographics, and clinical data were retrospectively analyzed. Results In total, 110 patients underwent indirect or combined bypass with follow-up DSA. The mean age of the enrolled patients was 42.4 ± 11.8 years. Previous ischemia (p = 0.001), previous hemorrhage (p = 0.013), bloody fluid volume (p = 0.049), and the time of imaging (p = 0.081) were associated with indirect outcomes. Ordinal regression analysis confirmed that good indirect outcomes were associated with previous ischemia (p < 0.001) and a large bloody fluid volume (p = 0.013). Further subgroups based on fluid volume were significantly correlated with IC establishment (p = 0.030). Conclusions A large bloody fluid volume and previous ischemic history were associated with good indirect outcomes. The presence of bloody fluids may reflect impaired degrees of muscular donors due to bipolar electrocoagulation, thus highlighting the importance of appropriate application of bipolar forceps.
Naturalizing Gravity of the Quantum Fields, and the Hierarchy Problem

It is shown that gravity can be incorporated into the Standard Model (SM) in a way solving the hierarchy problem. For this, the SM effective action in flat spacetime is adapted to curved spacetime via not only the general covariance but also the gauge invariance. For the latter, gauge field hard masses, induced by loops at the UV scale $\Lambda$, are dispelled by construing $\Lambda$ as the constant value assigned to curvature. This gives way to an unprecedented mechanism for incorporating gravity into the SM in that the hierarchy problem is solved by transmutation of the Higgs boson $\Lambda^2$--mass into the Higgs-curvature coupling, and the cosmological constant problem is alleviated by metamorphosis of the vacuum $\Lambda^4$--energy into the Einstein-Hilbert term. Gravity emerges correctly if the SM is accompanied by a secluded dark sector sourcing non-interacting dark matter, dark energy and dark radiation. Physics beyond the SM, containing Higgs-phobic scalars that resolve the strong CP problem, flavor problem, baryogenesis and inflation, respects the hierarchy. Majorana neutrinos are naturally incorporated if $\Lambda$ lies at the see-saw scale. This mechanism, in general, leaves no compelling reason to anticipate new particles at the LHC or higher-energy colliders.
Construction of prognostic signature of breast cancer based on N7-Methylguanosine-Related LncRNAs and prediction of immune response

Background: Long non-coding RNA (LncRNA) is a prognostic factor for malignancies, and N7-Methylguanosine (m7G) is crucial in the occurrence and progression of tumors. However, it has not been documented how well m7G-related LncRNAs predict the development of breast cancer (BC). This study aims to develop a predictive signature based on long non-coding RNAs (LncRNAs) associated with m7G to predict the prognosis of breast cancer patients. Methods: The Cancer Genome Atlas (TCGA) database provided us with the RNA-seq data and matching clinical information of individuals with breast cancer. To identify the signature of N7-Methylguanosine-Related LncRNAs and create a prognostic model, we employed co-expression network analysis, least absolute shrinkage selection operator (LASSO) regression analysis, univariate Cox regression analysis, and multivariate Cox regression analysis. The signature was assessed using the Kaplan-Meier analysis and Receiver Operating Characteristic (ROC) curve. A nomogram and principal component analysis (PCA) were employed to confirm the predictive signature’s usefulness. Then, we examined the drug sensitivity between the two risk groups and utilized single-sample gene set enrichment analysis (ssGSEA) to investigate the association between predictive factors and the tumor immune microenvironment in high-risk and low-risk groups. Results: Nine m7G-related LncRNAs (LINC01871, AP003469.4, Z68871.1, AC245297.3, EGOT, TFAP2A-AS1, AL136531.1, SEMA3B-AS1, AL606834.2) that are independently associated with the overall survival time (OS) of BC patients make up the signature we developed. For predicting 1-, 3-, and 5-year survival rates, the areas under the ROC curve (AUC) were 0.715, 0.724, and 0.726, respectively. The Kaplan-Meier analysis revealed that the prognosis of BC patients in the high-risk group was worse than that of those in the low-risk group. When compared to clinicopathological variables, multiple regression analysis demonstrated that risk score was a significant independent predictive factor for BC patients. The results of the ssGSEA study revealed a substantial correlation between the predictive traits and the BC patients’ immunological status, low-risk BC patients had more active immune systems, and they responded better to PD1/L1 immunotherapy. Conclusion: The prognostic signature, which is based on m7G-related LncRNAs, can be utilized to inform patients’ customized treatment plans by independently predicting their prognosis and how well they would respond to immunotherapy.
Association of egg intake with risks of cardiometabolic factors among adults in China

Objective To explore the association between egg intake and cardiometabolic factors (CMFs) in Chinese adults. Method The subjects were 6,182 adults aged 18–64 who had complete survey data and had no CMFs at baseline. Egg intake was assessed with 3 days−24 h dietary recalls in all waves of the China Health and Nutrition Survey (CHNS). Multivariate Cox proportional risk regression model and restricted cubic spline (RCS) model were used to analyze the association and dose-response relationship between egg intake and CMFs. Results Of the 6,182 participants who did not have metabolic syndrome (MetS) at baseline, 1,921 developed this disease during an average follow-up of 5.71 years, with an incidence of 31.07%. Central obesity, elevated TG, decreased HDL-C, elevated blood pressure and elevated plasma glucose were 38.65, 26.74, 30.21, 40.64, and 30.64%, respectively. After adjusting for demographic characteristics, lifestyle, energy and BMI, using the lowest quintile (Q1) as a reference, the risk of central obesity, elevated TG, decreased HDL-C, and elevated plasma glucose in the highest quintile (Q5) were reduced by 15% (HR = 0.85, 95% CI = 0.73–0.98, P = 0.16), 33% (HR = 0.67, 95% CI = 0.57–0.78), 25% (HR = 0.75, 95% CI = 0.63 0.90, p = 0.05), and 28% (HR = 0.72, 95% CI = 0.63–0.83, p < 0.05), respectively. The risk of elevated blood pressure was reduced by 26% in the fourth quintile (HR = 0.74, 95% CI = 0.64–0.85, P = 0.85). RCS analysis show that the overall correlation and nonlinear relationship between egg intake and CMFs were statistically significant (P < 0.05). When the intake was lower than 20 g/days, the risk of MetS, central obesity, elevated blood pressure and elevated plasma glucose were negatively correlated with egg intake, while elevated TG was negatively correlated with eggs when the intake was lower than 60 g/days. There was no statistically significant association between egg intake and CMFs at higher egg intake. Conclusion There was a U-shaped association between egg intake and CMFs in Chinese adults.
Gaussian concentration bounds for stochastic chains of unbounded memory

Stochastic chains of unbounded memory (SCUMs) are also known in the literature as “chains with complete connections” or “ g -measures”. We obtain Gaussian concentration bounds (GCB) in this large class of models, under two different conditions on the kernel: (1) when the sum of its oscillations is less than one, or (2) when the sum of its variations is ﬁnite, i.e. , belongs to (cid:96) 1 ( N ) . We also obtain explicit constants as functions of the parameters of the model. Our conditions are sharp in the sense that we exhibit examples of SCUMs that do not have GCB and for which the sum of oscillations is 1 + (cid:15) , or the variation belongs to (cid:96) 1+ (cid:15) ( N ) for any (cid:15) > 0 . These examples are based on the existence of phase transitions. We illustrate our results with four applications. First, we derive a Dvoretzky-Kiefer-Wolfowitz type inequality which gives a uniform control on the ﬂuctuations of the empirical measure. Second, in the ﬁnite-alphabet case, we obtain an upper bound on the ¯ d -distance between two stationary SCUMs and, as a by-product, we obtain new explicit bounds on the speed of Markovian approximation in ¯ d . Third, we derive new bounds on the ﬂuctuations of the “plug-in" estimator for entropy. Fourth, we obtain new rate of convergence for the maximum likelihood estimator of conditional probability.
Weighing the Cosmological Energy Contents with Weak Gravitational Lensing

Using perturbation theory, Bernardeau, Van Waerbeke, & Mellier show that the skewness of the large-scale lensing convergence, or projected mass density, could be used to constrain Ωm, the matter content of the universe. However, deep weak-lensing field surveys in the near future will likely measure the convergence on small angular scales (≲10'), where the signal will be dominated by highly nonlinear fluctuations. We develop a method for computing the small-scale convergence skewness that gives predictions that agree well with existing results from ray-tracing N-body simulations but is significantly faster. We demonstrate that the small-scale convergence skewness is insensitive to the shape and normalization of the primordial (cold dark matter-type) power spectrum, making it dependent almost entirely on the cosmological energy contents. Moreover, nonlinear clustering appears to enhance the differences between predictions of the convergence skewness for a range of models. Hence, in addition to constraining Ωm, the small-scale convergence skewness from future deep and several degrees wide surveys can be used to differentiate between curvature-dominated and cosmological constant (Λ)-dominated models, as well as to constrain the equation of state of a quintessence component, thereby distinguishing Λ from quintessence. Finally, our method can be easily generalized to other measures such as the aperture mass statistics.
ON THE ORIGINS OF THE HIGH-LATITUDE Hα BACKGROUND

The diffuse high-latitude Hα background is widely believed to be predominantly the result of in situ recombination of ionized hydrogen in the warm interstellar medium of the Galaxy. Instead, we show that both a substantial fraction of the diffuse high-latitude Hα intensity in regions dominated by Galactic cirrus dust and much of the variance in the high-latitude Hα background are the result of scattering by interstellar dust of Hα photons originating elsewhere in the Galaxy. We provide an empirical relation, which relates the expected scattered Hα intensity to the IRAS 100 μm diffuse background intensity, applicable to about 81% of the entire sky. The assumption commonly made in reductions of cosmic microwave background observations, namely that the observed all-sky map of diffuse Hα light is a suitable template for Galactic free–free foreground emission, is found to be in need of reexamination.
RLS BENCH : A Large-Scale Empirical Study of Domain Adaptation Under Relaxed Label Shift

Despite the emergence of principled methods for domain adaptation under label 1 shift (where only the class balance changes), the sensitivity of these methods to 2 natural-seeming covariate shifts remains precariously underexplored. Meanwhile, 3 popular deep domain adaptation heuristics, despite showing promise on benchmark 4 datasets, tend to falter when faced with shifts in the class balance. Moreover, it’s 5 difficult to assess the state of the field owing to inconsistencies among relevant 6 papers in evaluation criteria, datasets, and baselines. In this paper, we introduce 7 RLS BENCH , a large-scale benchmark for such relaxed label shift settings, consist-8 ing of 11 vision datasets spanning ą 200 distribution shift pairs with different class 9 proportions. We evaluate 12 popular domain adaptation methods, demonstrating a 10 more widespread susceptibility to failure under extreme shifts in the class propor-11
Greener and Efficient Epoxidation of 1,5-Hexadiene with tert-Butyl Hydroperoxide (TBHP) as an Oxidising Reagent in the Presence of Polybenzimidazole Supported Mo(VI) Catalyst

Alkene epoxidation with TBHP as an oxidising reagent using heterogeneous Mo(VI) catalyst is an environmentally friendly process since it eliminates acid waste and chlorinated by-products often associated with the conventional industrial method that uses stoichiometric peracid such as peracetic acid and m-chloroperbenzoic acid. Polybenzimidazole supported Mo(VI) complex, i.e., PBI.Mo has been successfully prepared, characterised and assessed for the epoxidation of 1,5-hexadiene in the presence of tert-butyl hydroperoxide (TBHP) as an oxidising reagent. A quadratic polynomial model has been developed, demonstrating the yield of 1,2-epoxy-5-hexene in four independent variables. The effects of different parameters such as reaction temperature, feed mole ratio of 1,5-hexadiene to TBHP, catalyst loading, and reaction time were studied. Response surface methodology (RSM) using Box-Behnken Design (BBD) was employed to study the interaction effect of different variables on the reaction response. This study presents the optimization of 1,5-hexadiene epoxidation in a batch reactor using TBHP as an oxidant and a polymer-supported Mo(VI) catalyst.