Miracle-dz/UniFAR-FTUs huggingface dataset:
Mainstream silicon carbide grains from meteorites

Primitive meteorites contain small quantities (up to several ppm) of presolar silicon carbide (SiC) grains. These grains show highly anomalous isotopic compositions of the major elements C and Si and of the trace elements N, Mg, Ca, Ti, Sr, Zr, Mo, Ba, Nd, Sm, Dy, and the noble gases. The isotopic compositions of most grains (“Mainstream” and the isotopically related minor type A, B, Y, and Z grains; ≈99% of total) show imprints of H burning (enhanced 13C and 14N; production of 26Al). He burning (enhanced 12C and 22Ne), the s-process (enhancements in the s-process isotopes of the heavy trace elements and in the neutron-rich isotopes of Si, Ca, and Ti), the galactic chemical evolution (variations in Si and Ti), and the galactic cosmic-ray activity (production of 21Ne). These grains are believed to have formed in the outflows of low-mass (1–3 M⊙) AGB stars. Although many of the isotopic features are satisfactorily explained by current astrophysical models, several serious problems and shortcomings still exi.
The Prevalence, Risk Factors, and Prognosis of Acute Kidney Injury After Lung Transplantation: A Single-Center Cohort Study in China.

PURPOSE The aim of this study is to evaluate the incidence, risk factors, and prognosis of acute kidney injury (AKI) after lung transplantation (LTx). METHODS Records of patients who underwent LTx in a single center were retrospectively reviewed. The prevalence of post-transplant AKI, the use of continuous renal replacement therapy (CRRT), and the risk factors for AKI were investigated. The effects of AKI and CRRT on short-term outcomes and long-term survival were measured. RESULTS This study included 148 patients, 67 of which developed postoperative AKI. Of these, 31 patients underwent CRRT; the percentage of cases with no AKI was 6.2%, and the percentage of cases with stage 1, 2, and 3 who used CRRT was 0%, 10%, and 86.2%, respectively. Patients with AKI had significantly higher intensive care unit mortality and in-hospital mortality. The 1-year post-LTx survival rate of patients with AKI was 47.8%, significantly lower than those without AKI (74.1%). There was no difference in 1-year survival rate of those with stage 1 and stage 2 AKI, but patients with stage 3 AKI showed the worst survival. Patients who underwent CRRT had an inferior survival outcome (9.7% vs 76.1%, P < .05). We found that higher acute physiologic assessment and chronic health evaluation (APACHE) II scores (odds ratio [OR] 1.082, P = .009) and higher intraoperative fluid balance (OR 1.001, P = .012) were independent risk factors, and female sex (OR 2.539) and pulmonary hypertension (OR 2.869) were potential risk factors for post-LTx AKI. A prediction model integration of the above factors showed a good concordance with actual risks and had a concordance index (C-index) of 0.76 (95% confidence interval [CI], 0.66-0.87). CONCLUSION Severe AKI requiring CRRT had a negative impact on the short-term and long-term outcomes of patients.
A feed-forward regulatory loop in adipose tissue promotes signaling by the hepatokine FGF21

In this study, Han et al. demonstrate that JNK signaling in adipocytes causes an increased circulating concentration of the hepatokine fibroblast growth factor 21 (FGF21) that regulates systemic metabolism. This regulatory loop represents a novel signaling paradigm that connects autocrine and endocrine signaling modes of the same hormone in different tissues.
Incidence of penalty corner injuries in international field hockey

ABSTRACT Field hockey penalty corners (PCs) put players at potential risk for injuries. This study evaluated the incidence of PC-related injuries with special regards to head injuries. Video sequences provided by the Fédération Internationale de Hockey (FIH) of 295 matches in 11 elite field hockey tournaments (2015–2016) were analysed for overall injuries and PC-related injuries in detail. In total, 13.9% of all match injuries (49/352 injuries) occurred in relation to a PC, accounting for 7.1 PC-related injuries per 1000 player match hours (95% CI 4.4–9.9). There were 11 head injuries afflicting six defenders and five attackers. One head injury was related to a direct hit by a ball (drag flick). This study provides the first data on PC-related injuries in elite field hockey. The recorded numbers and mechanisms of PC-related injuries should be used as a baseline for further studies and potential rule adaptations.
T‐wave and its association with myocardial fibrosis on cardiovascular magnetic resonance examination

Risk stratification in non‐ischemic myocardial disease poses a challenge. While cardiovascular magnetic resonance (CMR) is a comprehensive tool, the electrocardiogram (ECG) provides quick impactful clinical information. Studying the relationships between CMR and ECG can provide much‐needed risk stratification. We evaluated the electrocardiographic signature of myocardial fibrosis defined as presence of late gadolinium enhancement (LGE) or extracellular volume fraction (ECV) ≥29%.
Trial sequential analysis: plain and simple

cent times. However, not all readers may be familiar with this statistical technique. This correspondence aims to provide readers with the essentials to understand and interpret TSA. Adequately conducted meta-analyses (MAs) are considered the best evidence in the scientific literature. Nonetheless, MAs are exposed to misleading significant results (type I errors; α) or erroneously insignificant results (type II errors; β) caused by low quality or inadequately powered trials, publication bias, and repeated significance testing [1]. TSA is a cumulative MA method developed [1] to weigh α and β errors while estimating when the effect is large enough to be unlikely to be affected by further studies. TSA is displayed as a Cartesian graph with cumulative z-score on the y-axis and number of patients on the x-axis, subdivided into four zones by four lines: monitoring boundaries for benefit, and harm, and two futility boundaries (Fig. 1). Two lines parallel to the x-axis are usually displayed, showing the conventional statistically significant line at z, corresponding to 1.96. The cumulative z statistic line is constructed adding a study sequentially with chronological criteria. The end of the line corresponds to the lastly added study. It will lie in one of the following zones: “benefit”, “harm”, “inner wedge” or “not statistically significant”, representing a statistically significant result for the first two areas (“benefit” and “harm”) or a strong evidence that further studies will hardly be able to change the no-effect results (“inner wedge” area). Presence in the “not statistically significant” area means that further studies are needed. Control of α and β errors may be managed by decreasing the test statistic using a penalizing factor λ (law of the iterated logarithm) or adjusting the significance threshold. The last described strategy is managed in TSAs using α-and β-spending functions. The α spending function determines both the benefit and harm boundaries, while the beta spending function is displayed on the graph as the futility boundaries. The spending functions used in TSA are based on the O’BrienFleming’s function. Although several examples of such functions have been described, O’BrienFleming’s function is the only function implemented in the TSA software. The spending function is a monotonically increasing function that distributes the α error along the entire analysis for a pre-decided α. The function is defined from 0 to 1, where 0 corresponds to “no patient enrolled” and 1 to the “reached information size” with the information fraction (IF) as the independent variable. The IF is given by the accumulated sample divided by the required sample. The used α-spending function is
Emotional ambiguity and memory.

The emotional ambiguity hypothesis introduced the principle that uncertainty about items' valence determines how emotional content affects memory and other psychological processes. It was formulated to explain why correlations between the perceived valence and arousal of memory items range from weak to unreliable, but it also makes novel predictions. Although data are consistent with those predictions, the hypothesis does not provide a process model of how valence ambiguity causes the valence-arousal relation to fluctuate. We tested 2 such models-a quantitative one, which assumes that increasing ambiguity lowers the reliability of valence judgments, and a categorical/quantitative one, which assumes that increasing ambiguity restricts the range of valence judgments. These models predict different mathematical relations between measures of ambiguity and intensity for valence and other semantic attributes (e.g., arousal, concreteness, familiarity, imagery, meaningfulness). In Experiments 1-3, tests of those predictions favored the categorical/quantitative model-showing that ambiguity is an inverted-U function for valence and other attributes. Experiments 4 and 5 were designed to investigate whether the memory effects of valence ambiguity are similar to the known effects of valence intensity. In both experiments, recall improved when ambiguity was increased, as well as when intensity was increased. A mathematical model revealed that increases in ambiguity produced large increases in items' familiarity, whereas increases in intensity produced smaller increases in both recollection and familiarity. (PsycInfo Database Record (c) 2020 APA, all rights reserved).
Novel Thiosemicarbazones Sensitize Pediatric Solid Tumor Cell-Types to Conventional Chemotherapeutics through Multiple Molecular Mechanisms

Simple Summary Combination of chemotherapeutics for the treatment of childhood cancer can lead to the use of lower cytotoxic drug doses and better therapeutic tolerability (i.e., lower side effects) for patients. We discovered novel molecular targets of two lead thiosemicarbazone agents of the di-2-pyridylketone thiosemicarbazone class. These molecular targets include: cyclooxygenase, the DNA repair protein, O6-methylguanine DNA methyltransferase, mismatch repair proteins, and topoisomerase 2α. This research also identifies promising synergistic interactions of these thiosemicarbazones particularly with the standard chemotherapeutic, celecoxib. Abstract Combining low-dose chemotherapies is a strategy for designing less toxic and more potent childhood cancer treatments. We examined the effects of combining the novel thiosemicarbazones, di-2-pyridylketone 4-cyclohexyl-4-methyl-3-thiosemicarbazone (DpC), or its analog, di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone (Dp44mT), with the standard chemotherapies, celecoxib (CX), etoposide (ETO), or temozolomide (TMZ). These combinations were analyzed for synergism to inhibit proliferation of three pediatric tumor cell-types, namely osteosarcoma (Saos-2), medulloblastoma (Daoy) and neuroblastoma (SH-SY5Y). In terms of mechanistic dissection, this study discovered novel thiosemicarbazone targets not previously identified and which are important for considering possible drug combinations. In this case, DpC and Dp44mT caused: (1) up-regulation of a major protein target of CX, namely cyclooxygenase-2 (COX-2); (2) down-regulation of the DNA repair protein, O6-methylguanine DNA methyltransferase (MGMT), which is known to affect TMZ resistance; (3) down-regulation of mismatch repair (MMR) proteins, MSH2 and MSH6, in Daoy and SH-SY5Y cells; and (4) down-regulation in all three cell-types of the MMR repair protein, MLH1, and also topoisomerase 2α (Topo2α), the latter of which is an ETO target. While thiosemicarbazones up-regulate the metastasis suppressor, NDRG1, in adult cancers, it is demonstrated herein for the first time that they induce NDRG1 in all three pediatric tumor cell-types, validating its role as a potential target. In fact, siRNA studies indicated that NDRG1 was responsible for MGMT down-regulation that may prevent TMZ resistance. Examining the effects of combining thiosemicarbazones with CX, ETO, or TMZ, the most promising synergism was obtained using CX. Of interest, a positive relationship was observed between NDRG1 expression of the cell-type and the synergistic activity observed in the combination of thiosemicarbazones and CX. These studies identify novel thiosemicarbazone targets relevant to childhood cancer combination chemotherapy.
A longitudinal, narrative study of professional socialisation among health students

Interprofessional collaboration (IPC) among health professionals is well‐recognised to enhance care delivery and patient outcomes. Emerging evidence suggests that the early socialisation of students in health professional programmes to teamwork may have a positive impact on their future as collaborative practitioners. With a purpose of contributing to growing evidence on the processes of professional identity construction, and to explore how early expectations and perceptions of IPC develop during professional socialisation and pre‐licensure education, our study examined the early professional socialisation experiences among five groups of health professional students.
Use of Turkey Meat Affected by White Striping Myopathy for the Development of Low-Fat Cooked Sausage Enriched with Chitosan

The main objective of this research was the development of a healthy meat product from turkey meat with white striping myopathy. The effect of adding different proportions of chitosan on the qualitative characteristics, sensory acceptance, and stability of cooked sausages during storage was studied. Three treatments were elaborated (control, 1.5% chitosan, and 3% chitosan), stored for 56 days, and characterized in terms of chemical composition, texture profile analysis, drip and pressure loss analysis, and sensory analysis (after processing; day 0). In the different storage periods (0 and 56 days), the pH value, color, thiobarbituric acid reactive substances (TBARS), and volatile compounds were evaluated. The results showed that the moisture content, lipids, proteins, and weight loss decreased (p < 0.05) and the ash content increased (p < 0.05) with the addition of chitosan. Similarly, the values of texture parameters (hardness, cohesiveness, gumminess, and chewiness) were higher in the sausages reformulated with chitosan than in control samples. The addition of chitosan increased the pH and yellowness (b*) values and reduced (p < 0.05) redness (a*) and lightness (L*) values. The b* values (only in reformulated sausages) and pH increased during storage, while a* showed a significant reduction after 56 storage days. Lipid oxidation (TBARS) was kept below the limits of quantification in all samples and both after processing and 56 storage days. However, when quantifying the lipid-derived volatiles, a clear antioxidant activity of chitosan was observed, which limits the release of these compounds, mainly aldehydes (hexanal and nonanal). Finally, the sensory analysis indicated that, although chitosan treatments received the lowest scores for all attributes, the reformulated samples did not differ from control sausages. Therefore, sausage containing chitosan may represent an interesting alternative for adding value to turkey meats affected by white striping myopathy and, at the same time, develop into a healthy and functional meat product increasing the proportion of fibers in one’s diet.
Effect of the Refrigeration System on In Vitro Quality and In Vivo Fertility of Goat Buck Sperm

Simple Summary Artificial insemination of goats is mostly performed with sperm that has been chilled to 4 °C and stored for up to 12 h. Because the chilling of samples to 4 °C must be done slowly, artificial inseminations have to be performed late in the day, especially in herds located far from artificial insemination centers, which impedes the extensive use of this reproductive technology in goats. In this study, we explored the possibility of chilling sperm doses at a controlled rate (close to −0.18 °C/min) during transportation and compared the quality and fertility of these samples with those chilled in the lab. We observed that the in vitro quality of doses chilled by the prototype procedure developed for transportation was higher than that of samples chilled in the lab, and the fertility of the sperm was similar. Therefore, it is possible to chill doses during transportation without affecting their quality or fertility. Abstract Cooling goat sperm insemination doses to 4 °C causes a delay in their delivery. However, chilling these doses during the transportation period could expedite their delivery and the insemination process. In this study, an economical and simple apparatus for chilling goat semen doses in itinere was developed, and the in vitro quality and in vivo fertility of these doses were compared with those chilled by means of a programmable water bath in the laboratory at a rate of −0.18 °C/min. Of the tested prototypes, the one that provided an optimal combination of the chilling rate (average of −0.09 °C/min) and time required to reach 4 °C (3 h 45 min) was selected for further testing. Immediately after chilling and 24 h later, the doses chilled in the prototype were determined to be of higher quality than the samples chilled in the programmable water bath. Finally, the kidding rate was similar between the doses chilled in the programmable water bath (61.7% ± 7.1%) and in the prototype (56.1% ± 5.9%). In conclusion, successful chilling of goat sperm doses during transport is possible, thereby accelerating the delivery of insemination doses.
Incidence and Risk Factors for Symptomatic Spinal Epidural Hematoma Following Posterior Thoracic Spinal Surgery in a Single Institute

Study Design: Case-control study. Objectives: To investigate the incidence of symptomatic spinal epidural hematoma (SSEH) and recognize its risk factors in a cohort of patients undergoing posterior thoracic surgery in isolation. Methods: From January 2010 to December 2019, patients who developed SSEH after posterior thoracic surgery and underwent hematoma evacuation were enrolled. For each SSEH patient, 2 or 3 controls who did not develop SSEH and underwent the same procedures with similar complexity at the same section of the thoracic spine in the same period were collected. The preoperative and intraoperative factors, blood pressure-related factors and radiographic parameters were collected to identify possible risk factors by comparing between the 2 groups. Results: A total of 24 of 1612 patients (1.49%) were identified as having SSEH after thoracic spinal surgery. Compared to the control group (53 patients), SSEH patients had significant differences in the APTT (p = 0.028), INR (p = 0.009), ratio of previous spinal surgery (p = 0.012), ratio of cerebrospinal fluid leakage (p = 0.004), thoracic kyphosis (p<0.05), local kyphosis angle (p<0.05), epidural fat ratio at T7 (p = 0.003), occupying ratio of the cross-sectional area (p<0.05) and spinal epidural venous plexus grade (p<0.05). Multiple logistic regression analysis revealed 3 risk factors for SSEH: cerebrospinal fluid leakage, the local kyphosis angle (>8.77°) and the occupying ratio of the cross-sectional area (>49.58%). Conclusions: The incidence of SSEH was 1.49% in posterior thoracic spinal surgeries. Large local kyphosis angle (>8.77°), high occupying ratio of cross-sectional area (>49.58%) and cerebrospinal fluid leakage were identified as risk factors for SSEH.
Mechanisms Generating Cancer Genome Complexity: Back to the Future

Simple Summary In the 1990s, fluorescent in situ hybridization approaches made it possible to analyze the early stages of gene amplification in mammalian cells. These studies established breakage-fusion-bridge cycles as a major mechanism of intrachromosomal gene amplification. They also revealed that the amplified DNA perturbed nuclear architecture and led to micronucleation, which suggested a mechanism for the shortening of amplified units. The “interphase breakage model” postulated that the tremendous genomic instability occurring at early stages of gene amplification resulted from the interweaving of an amplification mechanism (breakage-fusion-bridge cycles) and of a deletion mechanism (micronucleation and stitching of DNA fragments retained in the nucleus). This model is strikingly consistent with recent data and conclusions obtained from live-cell imaging and single cell genome sequencing. The comparison of both sets of data suggests new questions to explore. Abstract Understanding the mechanisms underlying cancer genome evolution has been a major goal for decades. A recent study combining live cell imaging and single-cell genome sequencing suggested that interwoven chromosome breakage-fusion-bridge cycles, micronucleation events and chromothripsis episodes drive cancer genome evolution. Here, I discuss the “interphase breakage model,” suggested from prior fluorescent in situ hybridization data that led to a similar conclusion. In this model, the rapid genome evolution observed at early stages of gene amplification was proposed to result from the interweaving of an amplification mechanism (breakage-fusion-bridge cycles) and of a deletion mechanism (micronucleation and stitching of DNA fragments retained in the nucleus).
The Public Health Impact of Implementing a Concentration‐Based Microbiological Criterion for Controlling Salmonella in Ground Turkey

Despite initiatives to improve the safety of poultry products in the United States, progress has stalled, and salmonellosis incidence is still above Healthy People 2020's goal. One strategy to manage Salmonella and verify process control in poultry establishments is to implement microbiological criteria (MC) linked to public health outcomes. Concentration‐based MC have been used by the food industry; however, the public health impact of such approaches is only starting to be assessed. This study evaluated the public health impact of a concentration‐based MC for Salmonella in raw ground turkey consumed in the United States using a quantitative risk assessment modeling approach. The distribution of Salmonella concentration in ground turkey was derived from USDA‐FSIS monitoring surveys. Other variables and parameters were derived from public databases, literature, and expert opinion. Based on considered concentrations, implementing a MC of 1 cell/g led to an estimated 46.1% reduction (preventable fraction, PF) in the mean probability of illness when consumer cooking and cross‐contamination were included. The PF was consistent across scenarios including or excluding cross‐contamination and cooking, with slightly lower mean PF when cross‐contamination was included. The proportion of lots not compliant with the 1 cell/g MC was 1.05% in the main scenarios and increased nonlinearly when higher Salmonella concentrations were assumed. Assumptions on concentration variability across lots and within lots had a large impact, highlighting the benefit of reducing this uncertainty. These approach and results can help inform the development of MC to monitor and control Salmonella in ground turkey products.