Miracle-dz/UniFAR-FTUs huggingface dataset:
Wind diagnostics and correlations with the near-infrared excess in Herbig Ae/Be stars ?

Intermediate dispersion spectroscopic observations of 37 Herbig Ae/Be stars reveal that the equivalent widths of their(OI)6300andHemissionlines,arerelatedtotheirnear- infrared colours in the same fashion as the T-Tauri stars. Such a correlation strongly supports the idea that the winds from Herbig Ae/Be stars arise in the same manner as those from T- Tauri stars, i.e. through accretion driven mass-loss. We also nd that the (OI)6300 line luminosity correlates better with excess infrared luminosity than with stellar luminosities, again sup- porting the idea that Herbig Ae/Be winds are accretion driven. If one includes the lower mass analogues of the Herbig Ae/Be starswithforbiddenlineemission,i.e.theclassicalT-Tauristars, thecorrelationbetweenmass-lossrateandinfraredexcessspans 5 orders of magnitude in luminosity and a range of masses from 0.5M to approximately 10M. Our observations therefore ex- tend the ndings of Cohen et al. (1989) and Cabrit et al. (1990) for low mass young stars and, taken in conjunction with other evidence(Corcoran&Ray1997),stronglysupportthepresence of circumstellar disks around intermediate mass stars with for- bidden line emission. An implication of our ndings is that the same outflow model must be applicable to these Herbig Ae/Be stars and the classical T Tauri stars.
The life and times of the Enterococcus

Enterococci are important human pathogens that are increasingly resistant to antimicrobial agents. These organisms were previously considered part of the genus Streptococcus but have recently been reclassified into their own genus, called Enterococcus. To date, 12 species pathogenic for humans have been described, including the most common human isolates, Enterococcus faecalis and E. faecium. Enterococci cause between 5 and 15% of cases of endocarditis, which is best treated by the combination of a cell wall-active agent (such as penicillin or vancomycin, neither of which alone is usually bactericidal) and an aminoglycoside to which the organism is not highly resistant; this characteristically results in a synergistic bactericidal effect. High-level resistance (MIC, greater than or equal to 2,000 micrograms/ml) to the aminoglycoside eliminates the expected bactericidal effect, and such resistance has now been described for all aminoglycosides. Enterococci can also cause urinary tract infections; intraabdominal, pelvic, and wound infections; superinfections (particularly in patients receiving expanded-spectrum cephalosporins); and bacteremias (often together with other organisms). They are now the third most common organism seen in nosocomial infections. For most of these infections, single-drug therapy, most often with penicillin, ampicillin, or vancomycin, is adequate. Enterococci have a large number of both inherent and acquired resistance traits, including resistance to cephalosporins, clindamycin, tetracycline, and penicillinase-resistant penicillins such as oxacillin, among others. The most recent resistance traits reported are penicillinase resistance (apparently acquired from staphylococci) and vancomycin resistance, both of which can be transferred to other enterococci. It appears likely that we will soon be faced with increasing numbers of enterococci for which there is no adequate therapy.
Spatial filtering of the fetal electrocardiogram

One of the basic problems in the analysis of the rhythm and the shape of the fetal ECG (FECG) is the interference caused by the electrical activity of the maternal heart (MECG). Methods devised for suppressing the maternal signals in the abdominally recorded leads obviously have to rely on differences in the characteristics of both kinds of signals. In the past various differences have been employed for this purpose such as differences in wave shape, frequency content and source location. The method presented here is based on the latter principle. The electrical sources of the fetal and maternal heart are clearly separated in space. By employing multiple abdominal leads, a linear combination of the recorded signals can be formed which acts effectively as a spatial filter. As such the filtering characteristics depend exclusively on the separation inside the human body (the electrical volume conductor) and, as such, can be expected to be independent of the temporal aspects of the recorded signals. In particular, the obtained filter is unaffected by the occurrence of ectopic beats in either the fetal or the maternal heart. The determination of the required filter (weighting coefficients) is carried out by using the technique of singular value decomposition (SVD) of the data matrix representing the sampled input signals. The filter effectively suppresses the maternal component in the filter output and optimizes the fetal component. The properties of this filter are demonstrated.
Cyr61 and YB-1 are novel interacting partners of uPAR and elevate the malignancy of triple-negative breast cancer

The triple-negative breast cancer (TNBC) is a very aggressive tumor type often occurring in young women and is associated with a bad prognosis for the patients. TNBC lacks established targets for breast cancer therapy, such as the estrogen receptor (ER), progesterone receptor (PR) and the human epidermal growth factor receptor 2 (HER2). Therefore, novel therapeutic targets and strategies are needed for an improved treatment of this breast cancer subtype. TNBC and respective cell lines often overexpress proteins of the urokinase plasminogen activator system (uPAS) including uPA, its receptor uPAR and inhibitor PAI-1, which together with co-factors contribute to the malignancy of TNBC. Here, two novel interacting partners of uPAR, the cysteine-rich angiogenic inducer 61 (Cyr61) and the Y-box-binding protein 1 (YB-1) were identified and their differential expression demonstrated in TNBC cells as well as in tumors. In the TNBC cohort, both interactors significantly correlated with expression levels of cathepsin B, c-Met and the tumor grade. In addition, expression levels of Cyr61 significantly correlated with cathepsin D (p=0.03), insulin receptor (p≤0.001), insulin-like growth factor receptor 1 (IGF1R, p=0.015) and also with YB-1 (p=0.0004) levels. The interactions of uPAR with Cyr61 significantly correlated with expression levels of tumor-promoting biomarkers including plasminogen (p=0.0014), cathepsin B (p=0.032), c-Met (p=0.0192) as well as with the tumor grade (p=0.02). In multivariate survival analysis, YB-1 showed independent prognostic value (p=0.01). As the novel interacting partners, also together with uPAR, contribute to tumor progression and metastasis, both may be potential therapeutic targets in breast cancer.
Analysis of fine-grained urban temperature collected with a sensor network

Temperature in a metropolitan area exhibits a complicated tendency. Rather than geographical closeness, structures of a group of buildings and streets can affect changes in temperature. To identify the tendency of fine-grained distribution of temperature, we installed a densely-distributed sensor network called UScan. In this paper we describe a system of UScan and effective placement of sensors based on our experiment in downtown Tokyo. We also propose a clustering method to analyze the correlation between the tendency of temperature and the environmental factors.
Finite-State Non-Concatenative Morphotactics

We describe a new technique for constructing finite-state transducers that involves reapplying the regular-expression compiler to its own output. Implemented in an algorithm called compile-replace, this technique has proved useful for handling non-concatenative phenomena; and we demonstrate it on Malay full-stem reduplication and Arabic stem interdigitation.
Molecular Characterization and Phylogenetic Study of Coxsackievirus A24v Causing Outbreaks of Acute Hemorrhagic Conjunctivitis (AHC) in Brazil

Background Coxsackievirus A24 variant (CA24v) is the most prevalent viral pathogen associated with acute hemorrhagic conjunctivitis (AHC) outbreaks. Sixteen years after its first outbreak in Brazil, this agent reemerged in 2003 in Brazil, spread to nearly all states and caused outbreaks until 2005. In 2009, a new outbreak occurred in the northeast region of the country. In this study, we performed a viral isolation in cell culture and characterized clinical samples collected from patients presenting symptoms during the outbreak of 2005 in Vitória, Espírito Santo State (ES) and the outbreak of 2009 in Recife, Pernambuco State (PE). We also performed a phylogenetic analysis of worldwide strains and all meaningful Brazilian isolates since 2003. Methods and Findings Sterile cotton swabs were used to collect eye discharges, and all 210 clinical samples were used to inoculate cell cultures. Cytopathic effects in HEp-2 cells were seen in 58 of 180 (32%) samples from Vitória and 3 of 30 (10%) samples from Recife. Phylogenetic analysis based on a fragment of the VP1 and 3C gene revealed that the CA24v causing outbreaks in Brazil during the years 2003, 2004 and 2005 evolved from Asian isolates that had caused the South Korean outbreak of AHC during the summer of 2002. However, the 2009 outbreak of AHC in Pernambuco was originated from the reintroduction of a new CA24v strain that was circulating during 2007 in Asia, where CA24v outbreaks has been continuously reported since 1970. Conclusions This study is the first phylogenetic analysis of AHC outbreaks caused by CA24v in Brazil. The results showed that Asian strains of CA24v were responsible for the outbreaks since 1987 and were independently introduced to Brazil in 2003 and 2009. Phylogenetic analysis of complete VP1 gene is a useful tool for studying the epidemiology of enteroviruses associated with outbreaks.
Acute Blood Pressure Lowering, Vasoprotective, and Antiplatelet Properties of Dietary Nitrate via Bioconversion to Nitrite

Diets rich in fruits and vegetables reduce blood pressure (BP) and the risk of adverse cardiovascular events. However, the mechanisms of this effect have not been elucidated. Certain vegetables possess a high nitrate content, and we hypothesized that this might represent a source of vasoprotective nitric oxide via bioactivation. In healthy volunteers, approximately 3 hours after ingestion of a dietary nitrate load (beetroot juice 500 mL), BP was substantially reduced (&Dgr;max −10.4/8 mm Hg); an effect that correlated with peak increases in plasma nitrite concentration. The dietary nitrate load also prevented endothelial dysfunction induced by an acute ischemic insult in the human forearm and significantly attenuated ex vivo platelet aggregation in response to collagen and ADP. Interruption of the enterosalivary conversion of nitrate to nitrite (facilitated by bacterial anaerobes situated on the surface of the tongue) prevented the rise in plasma nitrite, blocked the decrease in BP, and abolished the inhibitory effects on platelet aggregation, confirming that these vasoprotective effects were attributable to the activity of nitrite converted from the ingested nitrate. These findings suggest that dietary nitrate underlies the beneficial effects of a vegetable-rich diet and highlights the potential of a “natural” low cost approach for the treatment of cardiovascular disease.
How to add content-based image retrieval capability in a PACS

This paper presents a new picture archiving and communication system (PACS), called cbPACS (content-based PACS), which has content-based image retrieval resources. cbPACS answers similarity (range and nearest-neighbor) queries, taking advantage of a metric access method embedded into the image database manager. The images are compared via their features, which are extracted by an image processing system module. The system works on features based on the color distribution of the images through normalized histograms as well as metric histograms. Metric histograms are invariant with regard to scale, translation and rotation of images and also to brightness transformations. cbPACS is prepared to integrate new image features, based on the texture and shape of the main objects in the image.
Labor Market Changes In Response To Immigration : Evidence From Internal Migration Driven By Weather Shocks

We study the labor market impact of internal migration in Indonesia by instrumenting migrant flows with rainfall shocks at the origin area. Estimates reveal that a one percentage point increase in the share of migrants decreases income by 1.22 percent and reduces employment by 0.26 percentage points. These effects are different across sectors: employment reductions are concentrated in the formal sector, while income reduction occurs in the informal sector. Negative consequences are most pronounced for low-skilled natives, even though migrants are systematically highly skilled. We suggest that the two-sector nature of the labor market may explain this pattern. JEL Classification: J21, J61, O15 Kleemans: Department of Economics, University of Illinois at Urbana-Champaign; Magruder: Department of Agricultural and Resource Economics, University of California at Berkeley. Corresponding email address: kleemans@illinois.edu. We are grateful to Max Auffhammer Michael Anderson, Sam Bazzi, Marshall Burke, David Card, Michael Clemens, Alain de Janvry, Edward Miguel, Sofia Villas-Boas and seminar participants at numerous presentations. We gratefully acknowledge financial support from the U.C. Berkeley Population Center. All errors are our own.
Expression of bradykinin receptors in the left ventricles of rats with pressure overload hypertrophy and heart failure

Objectives Bradykinin exerts cardioprotective effects through bradykinin type-2 receptors (BK-2Rs). After acute myocardial infarction in rat, the heart adapts by increasing its number of BK-2Rs. However, in human chronic end-stage heart failure, the number of BK-2Rs is significantly decreased. Thus, the presence of a cardioprotective BK-2R signaling system may be critical in the prevention of pressure overload-induced heart failure. Design To explain differences in myocardial BK-2R expression during cardiac overload, we studied: (1) spontaneously hypertensive rats (SHRs) of different ages, and (2) normotensive Sprague–Dawley rats subjected to aortic banding or angiotensin II infusion. Methods and results The mRNA levels of BK-2Rs were found to be significantly (P < 0.05) increased in the aging (12 and 20-month-old) SHRs (2.9- and 3-fold, respectively). Similarly, in the Sprague–Dawley rats, the expression of BK-2Rs was increased at 12 h (1.8-fold, P < 0.05) and at 3 days (3.1-fold, P < 0.05) after aortic banding, and at 2 weeks (2.2-fold) after angiotensin II infusion. In the 12-month-old SHRs, with compensated left ventricular hypertrophy (no fibrosis or left ventricular dysfunction), the amount of BK-2Rs was also significantly increased (1.8-fold, P < 0.05). However, in the 20-month-old SHRs, with a dramatic increase in fibrosis and development of diastolic dysfunction and heart failure, the amount of BK-2Rs were significantly decreased (63%, P < 0.05) specifically in the cardiac endothelial cells. Conclusions The present results show that, during pressure overload and compensated left ventricular hypertrophy, the expression of BK-2Rs is increased. However, ongoing pressure overload leads to a loss of BK-2Rs with a dramatic increase in left ventricular fibrosis followed by diastolic dysfunction and heart failure.
Total Correctness of Recursive Functions using JML 4 FSPV

JML4 is a next generation tooling and research platform for JML. JML4, currently in development, aims to support the integrated capabilities of Runtime Assertion Checking (RAC), Extended Static Checking (ESC), and Full Static Program Verification (FSPV). In this paper, we present the JML4 FSPV Theory Generator (TG) that aims to study the adequacy of Isabelle/Simpl as the underlying verification condition language. In particular we study Isabelle/Simpl with respect to proving total correctness of recursive programs. Simpl is a Hoare-based logic for a sequential imperative programming language along with a verification system. It is written in Isabelle/HOL and has been proven sound and relative complete.
The Digital Music Lab

In musicology and music research generally, the increasing availability of digital music, storage capacities, and computing power enable and require new and intelligent systems. In the transition from traditional to digital musicology, many techniques and tools have been developed for the analysis of individual pieces of music, but large-scale music data that are increasingly becoming available require research methods and systems that work on the collection-level and at scale. Although many relevant algorithms have been developed during the past 15 years of research in Music Information Retrieval, an integrated system that supports large-scale digital musicology research has so far been lacking. In the Digital Music Lab (DML) project, a collaboration among music librarians, musicologists, computer scientists, and human-computer interface specialists, the DML software system has been developed that fills this gap by providing intelligent large-scale music analysis with a user-friendly interactive interface supporting musicologists in their exploration and enquiry. The DML system empowers musicologists by addressing several challenges: distributed processing of audio and other music data, management of the data analysis process and results, remote analysis of data under copyright, logical inference on the extracted information and metadata, and visual web-based interfaces for exploring and querying the music collections. The DML system is scalable and based on Semantic Web technology and integrates into Linked Data with the vision of a distributed system that enables music research across archives, libraries, and other providers of music data. A first DML system prototype has been set up in collaboration with the British Library and I Like Music Ltd. This system has been used to analyse a diverse corpus of currently 250,000 music tracks. In this article, we describe the DML system requirements, design, architecture, components, and available data sources, explaining their interaction. We report use cases and applications with initial evaluations of the proposed system.
Adherence of Vibrio cholerae to cultured differentiated human intestinal cells: an in vitro colonization model

Choleragenic vibrios adhered to and multiplied on monolayers of the highly differentiated mucin-secreting cell line HT29-18N2. Their adherence followed first-order kinetics, was dependent on the concentration of vibrios, and was partially inhibited by lipopolysaccharide. Comparison of genetically modified vibrios showed that flagella, an active toxR gene, and the virulence cassette were not essential for initial binding. Inactivation of the hemagglutinin/protease increased binding. This highly differentiated human intestinal cell line provides a versatile new approach for studying major events occurring during intestinal colonization: adherence, multiplication, and detachment.
Arabidopsis DELLA and JAZ Proteins Bind the WD-Repeat/bHLH/MYB Complex to Modulate Gibberellin and Jasmonate Signaling Synergy[C][W]

GA and JA regulate diverse aspects of plant growth, development, and defense. This work reveals a mechanism for GA and JA signaling synergy and identifies a signaling complex for the GA pathway: DELLAs and JAZs interact with and repress the WD-repeat/bHLH/MYB complex to mediate the synergistic action between GA and JA signaling in regulating trichome development. Integration of diverse environmental and endogenous signals to coordinately regulate growth, development, and defense is essential for plants to survive in their natural habitat. The hormonal signals gibberellin (GA) and jasmonate (JA) antagonistically and synergistically regulate diverse aspects of plant growth, development, and defense. GA and JA synergistically induce initiation of trichomes, which assist seed dispersal and act as barriers to protect plants against insect attack, pathogen infection, excessive water loss, and UV irradiation. However, the molecular mechanism underlying such synergism between GA and JA signaling remains unclear. In this study, we revealed a mechanism for GA and JA signaling synergy and identified a signaling complex of the GA pathway in regulation of trichome initiation. Molecular, biochemical, and genetic evidence showed that the WD-repeat/bHLH/MYB complex acts as a direct target of DELLAs in the GA pathway and that both DELLAs and JAZs interacted with the WD-repeat/bHLH/MYB complex to mediate synergism between GA and JA signaling in regulating trichome development. GA and JA induce degradation of DELLAs and JASMONATE ZIM-domain proteins to coordinately activate the WD-repeat/bHLH/MYB complex and synergistically and mutually dependently induce trichome initiation. This study provides deep insights into the molecular mechanisms for integration of different hormonal signals to synergistically regulate plant development.
U.S. Households' Perception of Drinking Water as Unsafe and its Consequences: Examining Alternative Choices to the Tap

Using 2015 American Housing Survey data, this study generates the first national estimates of the use of drinking water alternatives among households who perceive their tap water to be unsafe. Multivariate regression models examine factors influencing both perception of tap water and the choice of tap alternatives. We find that minority households more commonly perceive their tap water to be unsafe and choose bottled water when they perceive the tap as unsafe. While perception of unsafe tap water is most prevalent among Hispanic households, among the population perceiving their tap to be unsafe, Black households more commonly buy bottled water. We estimate the minimum annual expenditure by all U.S. households who perceive the tap as unsafe and buy bottled water to meet necessary consumption standards at $5.65 billion annually. Novel secondary treatment interventions and education campaigns are needed to address the perception of tap water as unsafe and consequent alternative source reliance, while additional research is needed to document the active trade‐offs households make to manage their water sources, and to better understand determinants of the perception of tap water as unsafe within minority groups.
Attachment security moderates the link between adverse childhood experiences and cellular aging

Abstract Exposure to childhood adversity has been linked to accelerated telomere shortening, a marker of cellular aging and an indicator of physical health risk. In the current study, we examined whether adult attachment representation moderated the association between childhood adversity and telomere length. Participants included 78 young adults (M age = 20.46, SD = 1.57), who reported on their exposure to adverse childhood experiences (ACE) and were administered the Adult Attachment Interview, which was coded for attachment state of mind. Relative telomere length was assayed from buccal cells. Multiple regression analyses revealed a significant interaction between attachment state of mind and ACE in predicting telomere length. Whereas the association between number of ACE and telomere length was nonsignificant for secure–autonomous, r (50) = –. 15, p = . 31, and insecure–preoccupied young adults, r (9) = –. 15, p = . 71, there was a strong negative association between number of ACE and telomere length for insecure–dismissing young adults, r (19) = –. 59, p = . 007. This study is novel in demonstrating that attachment may affect biological resilience following childhood adversity, contributing to the growing literature about the role of the quality of early caregiving experiences and their representations in shaping biological processes and physical health.