Miracle-dz/UniFAR-FTUs huggingface dataset:
WEB vs coiling in ruptured aneurysms: A propensity score matched comparison of safety and efficacy

Background We aim to compare the safety and efficacy of WEB with coiling for acutely ruptured aneurysms. METHODS: All consecutive ruptured aneurysms with width suitable for WEB (2–10 mm) treated over 5 years (1/1/2015 to 31/12/2019) were included. We recorded WFNS, Fisher grade, patient demographics and aneurysm characteristics (size, location, D/W and aspect ratio, lobulation). Primary endpoints were mRS status at 3 months, aneurysm occlusion on latest available imaging follow-up, retreatment rate and procedural complications. We applied propensity score matching using aneurysm morphology (size, D/N ratio, ASPECT ratio and lobulation) to optimise matching for WEB versus coil comparison and minimise the effects of confounding. Result A total of 493 patients were identified, 97 treated with the WEB device. 1:1 propensity score matching was used to establish a matched group of 97 patients treated with coiling. The WEB arm showed 3% procedural complication rate, with no haemorrhagic complications and use of adjunctive device in 4%. Satisfactory occlusion on follow-up (mean 14 months) was 79%, with 19% retreatment rate. The coil arm had 8% complication rate, with use of an adjunctive device in 52% of cases (balloon 44%, stent 8%). Satisfactory occlusion on follow-up (mean 22 months) was 90%, with 8% retreatment rate. Conclusion Treatment of ruptured wide-necked bifurcation aneurysms with WEB has a lower complication rate than coiling with high rate of satisfactory occlusion. However, there was a higher retreatment rate when compared with patients treated with coiling. An adjunct device (balloon or stent), was used in over 50% of aneurysms in the coiling group.
Effect of classical and molecular production techniques on physical properties and volatile compounds of berry ice-creams

This study aims to investigate some chemical, physical, textural, and aroma compounds properties of the ice-cream with berry fruits produced using classical and molecular ice-cream production techniques. No significant difference was determined between the pH, dry solid, fat, protein, ash amounts, and overrun of the samples. However, molecular ice-creams, in particular, have a softer structure since they contain tiny ice crystals, and the first dripping and full melting time was realized in less time. The effect of added fruit variety on the viscosity value of the samples was found to be significant. It was observed that the volatile compound profiles of the ice-creams were affected differently by ice-cream production techniques. The octanoic, hexanoic, and dodecanoic acid were high-value prominent compounds in all the ice creams. Furthermore, the 14 volatile compounds that are effective in the difference between the ice-creams and their production techniques were determined, which is more important in the ice cream aroma. This is the first study on the change of the volatile compounds, hence the aroma compound profile, in molecular ice-cream production technique. And, it was presented as an innovative approach. Therefore, it is thought to be shed new light on future studies.
Tafenoquine for the treatment of Plasmodium vivax malaria

ABSTRACT Introduction Plasmodium vivax malaria causes significant disease burden worldwide, especially in Latin America, Southeast Asia, and Oceania. P. vivax is characterized by the production of liver hypnozoites that cause clinical relapses upon periodic activation. Primaquine, an 8-aminoquinoline drug, has been the standard of care for decades to treat liver-stage P. vivax malaria; however, it requires long treatment regimens (one to two weeks) that lead to poor adherence and thus clinical relapses. Tafenoquine (TFQ), a newly available and efficacious single-dose 8-aminoquinoline, aims to address this challenge. Safe administration is possible when paired with the use of glucose-6-phosphate dehydrogenase (G6PD) diagnostics to prevent 8-aminoquinoline-induced hemolysis in patients with underlying G6PD deficiency (G6PDd). Areas covered In this review, the authors present the recent literature regarding the pharmacology, efficacy, safety, and tolerability of TFQ and highlight regional differences in these areas. The authors also discuss the potential for TFQ, complemented with primaquine PQ and effective screening for G6PDd, to improve P. vivax clinical management and facilitate targeted mass drug administration in communities to decrease transmission. Expert opinion Clinical studies show therapeutic efficacy of TFQ as well as a good performance in terms of safety and tolerability. Additional research regarding the effectiveness and safety TFQ in malaria elimination strategies, such as targeted or mass drug administration, are needed.
The relationship between stigma and mental health in a population of individuals with COVID-19.

PURPOSE Illness stigma has been observed across previous outbreaks including Ebola, SARS, HIV/AIDS, and now COVID-19. Although both the stigma of having COVID-19 as well as mental health impacts of COVID-19 have been studied, limited research exists regarding the relationship of stigma and mental health in this population. Thus, the primary purpose of the present study was to examine the relationship between stigma and mental health in adults with COVID-19. METHOD Adult respondents with a diagnosis of COVID-19 (N = 632) completed an online questionnaire distributed between April 17, 2020, and April 18, 2021. The study measures included the Patient Health Questionnaire 8 (PHQ-8), the Generalized Anxiety Disorder 7-item (GAD-7), and the 8-Item Stigma Scale for Chronic Illness (SSCI-8) tailored to measure perceived stigmatization from a COVID-19 diagnosis. RESULTS Participants (mean age = 51) were mostly female (71%), White (73%), married (70%), obese (56%), and had a chronic health condition (56%). Female sex, education status, working from home or not working owing to COVID-19, previous mental health diagnosis, history of chronic illness, and being a current/former smoker were associated with higher stigma scores, whereas older age and Black race were associated with lower stigma scores. CONCLUSIONS Greater stigma and psychological distress was observed in females with a previously diagnosed psychiatric illness and/or chronic health condition. Our findings suggest a disproportionate burden of mental health/psychiatric symptoms/sequelae, including stigma and PTSD, among COVID-19 survivors with a history of mental illness. Further studies are needed to fully characterize COVID-19 related stigma and subsequent mental health experiences. (PsycInfo Database Record (c) 2022 APA, all rights reserved).
Current WHO recommendation to reduce free sugar intake from all sources to below 10% of daily energy intake for supporting overall health is not well supported by available evidence

ABSTRACT Sugar is widely consumed over the world. Although the mainstream view is that high added or free sugar consumption leads to obesity and related metabolic diseases, controversies exist. This narrative review aims to highlight important findings and identify major limitations and gaps in the current body of evidence in relation to the effect of high sugar intakes on health. Previous animal studies have shown that high sucrose or fructose consumption causes insulin resistance in the liver and skeletal muscle and consequent hyperglycemia, mainly because of fructose-induced de novo hepatic lipogenesis. However, evidence from human observational studies and clinical trials has been inconsistent, where most if not all studies linking high sugar intake to obesity focused on sugar-sweetened beverages (SSBs), and studies focusing on sugars from solid foods yielded null findings. In our opinion, the substantial limitations in the current body of evidence, such as short study durations, use of supraphysiological doses of sugar or fructose alone in animal studies, and a lack of direct comparisons of the effects of solid compared with liquid sugars on health outcomes, as well as the lack of appropriate controls, seriously curtail the translatability of the findings to real-world situations. It is quite possible that “high” sugar consumption at normal dietary doses (e.g., 25% daily energy intake) per se—that is, the unique effect of sugar, especially in the solid form—may indeed not pose a health risk for individuals apart from the potential to reduce the overall dietary nutrient density, although newer evidence suggests “low” sugar intake (<5% daily energy intake) is just as likely to be associated with nutrient dilution. We argue the current public health recommendations to encourage the reduction of both solid and liquid forms of free sugar intake (e.g., sugar reformulation programs) should be revised due to the overextrapolation of results from SSBs studies.
Hereditary haemorrhagic telangiectasia with atrial septal defect and pulmonary hypertension during advanced pregnancy: a case report and literature review

Pregnancy complicated with hereditary haemorrhagic telangiectasia (HHT) is a rare condition. This case report presents an extremely rare case with the co-occurrence of HHT and congenital heart disease. In this report, a 43-year-old woman at 36 + 4 weeks of gestation experienced haemoptysis with a volume of approximately 300 ml for the first time. Uncommonly, her transthoracic echocardiogram revealed a previously unrecognized atrial septal defect (ASD) and pulmonary hypertension (PH) for the first time at 36 + 1 weeks of gestation. Chest computed tomography revealed an arteriovenous malformation (AVM) in the right lower lobe of the lung. Due to concerns of rebleeding of ruptured pulmonary arteriovenous malformations (PAVMs), the patient underwent a caesarean section at 36 + 6 weeks of gestation. A healthy male infant weighing 2800 g was delivered. To the best of our knowledge, there have been few reports about HHT with ASDs and PH during advanced pregnancy. This current case report highlights the necessity for clinicians to pay considerable attention to cardiac structural abnormalities, which can worsen PAVM in patients with HHT during pregnancy, for whom terminating the pregnancy in time may reduce the risk of PAVM rupture.
Asynchronous Spatio-Temporal Memory Network for Continuous Event-Based Object Detection

Event cameras, offering extremely high temporal resolution and high dynamic range, have brought a new perspective to addressing common object detection challenges (e.g., motion blur and low light). However, how to learn a better spatio-temporal representation and exploit rich temporal cues from asynchronous events for object detection still remains an open issue. To address this problem, we propose a novel asynchronous spatio-temporal memory network (ASTMNet) that directly consumes asynchronous events instead of event images prior to processing, which can well detect objects in a continuous manner. Technically, ASTMNet learns an asynchronous attention embedding from the continuous event stream by adopting an adaptive temporal sampling strategy and a temporal attention convolutional module. Besides, a spatio-temporal memory module is designed to exploit rich temporal cues via a lightweight yet efficient inter-weaved recurrent-convolutional architecture. Empirically, it shows that our approach outperforms the state-of-the-art methods using the feed-forward frame-based detectors on three datasets by a large margin (i.e., 7.6% in the KITTI Simulated Dataset, 10.8% in the Gen1 Automotive Dataset, and 10.5% in the 1Mpx Detection Dataset). The results demonstrate that event cameras can perform robust object detection even in cases where conventional cameras fail, e.g., fast motion and challenging light conditions.
Mllt11 Regulates Migration and Neurite Outgrowth of Cortical Projection Neurons during Development

The formation of connections within the mammalian neocortex is highly regulated by both extracellular guidance mechanisms and intrinsic gene expression programs. There are two types of cortical projection neurons (CPNs): those that project locally and interhemispherically and those that project to subcerebral structures such as the thalamus, hindbrain, and spinal cord. The regulation of cortical projection morphologies is not yet fully understood at the molecular level. Here, we report a role for Mllt11 (Myeloid/lymphoid or mixed-lineage leukemia; translocated to chromosome 11/All1 Fused Gene From Chromosome 1q) in the migration and neurite outgrowth of callosal projection neurons during mouse brain formation. We show that Mllt11 expression is exclusive to developing neurons and is enriched in the developing cortical plate (CP) during the formation of the superficial cortical layers. In cultured primary cortical neurons, Mllt11 is detected in varicosities and growth cones as well as the soma. Using conditional loss-of-function and gain-of-function analysis we show that Mllt11 is required for neuritogenesis and proper migration of upper layer CPNs. Loss of Mllt11 in the superficial cortex of male and female neonates leads to a severe reduction in fibers crossing the corpus callosum (CC), a progressive loss in the maintenance of upper layer projection neuron gene expression, and reduced complexity of dendritic arborization. Proteomic analysis revealed that Mllt11 associates with stabilized microtubules, and Mllt11 loss affected microtubule staining in callosal axons. Taken together, our findings support a role for Mllt11 in promoting the formation of mature upper-layer neuron morphologies and connectivity in the cerebral cortex. SIGNIFICANCE STATEMENT The regulation of cortical projection neuron (CPN) morphologies is an area of active investigation since the time of Cajal. Yet the molecular mechanisms of how the complex dendritic and axonal morphologies of projection neurons are formed remains incompletely understood. Although conditional mutagenesis analysis in the mouse, coupled with overexpression assays in the developing fetal brain, we show that a novel protein called Mllt11 is sufficient and necessary to regulate the dendritic and axonal characteristics of callosal projection neurons in the developing mammalian neocortex. Furthermore, we show that Mllt11 interacts with microtubules, likely accounting for its role in neuritogenesis.
Developing a model of return to school: A Traumatic Brain Injury Model Systems study

ABSTRACT Objective A common goal for those recovering from moderate to severe brain injury is to reengage in education or employment. There is significant overlap between the skills relevant for successful job and academic performance in high school and college, and many deficits reported after brain injury are consistent across young adults and adults. This study utilized a return to work (RTW) model framework to develop a model of return to school (RTS). Method Days of post-traumatic amnesia (PTA), length of stay (LOS), rehabilitation discharge Disability Rating Scale (DRS) scores, presence of pre-injury learning limitation, and educational level were used to predict RTS one-year post-injury in a student sample (N = 158, 58.8% white, 69.6% male) within the Traumatic Brain Injury Model Systems National Database. Results The overall RTS rate for this sample was 62%. Logistic regression indicated that lower DRS discharge scores and being in high school pre-injury resulted in the best outcome. Conclusion Results showed partial support for the translation of RTW factors to a student sample; however, results may also favor the conceptual distinction in RTS versus RTW, which are elaborated. More outreach for college students may improve awareness of disability services, thereby heightening the future return rate.
Quantifying the contribution of evaporation from Lake Taihu to precipitation with an isotope-based method

ABSTRACT Moisture recycling plays a crucial role in regional hydrological budgets. The isotopic composition of precipitation has long been considered as a good tracer to investigate moisture recycling. This study quantifies the moisture recycling fractions (f r) in the Lake Taihu region using spatial variations of deuterium excess in precipitation (d P) and surface water vapour flux (d E). Results show that d P at a site downwind of the lake was higher than that at an upwind site, indicating the influence of lake moisture recycling. Spatial variations in d P after sub-cloud evaporation corrections were 2.3, 1.4 and 3.2 ‰, and d E values were 27.4, 32.3 and 31.4 ‰ for the first winter monsoon, the summer monsoon and the second winter monsoon, respectively. Moisture recycling fractions were 0.48 ± 0.13, 0.07 ± 0.03 and 0.38 ± 0.05 for the three monsoon periods, respectively. Both using the lake parameterization kinetic fractionation factors or neglecting sub-cloud evaporation would decrease f r, and the former has a larger influence on the f r calculation. The larger f r in the winter monsoon periods was mainly caused by lower specific humidity of airmasses but comparable moisture uptake along their trajectories compared to the summer monsoon period.
Omalizumab for the Treatment of Bullous Pemphigoid: A Systematic Review of Efficacy and Safety

Bullous pemphigoid (BP) is an autoimmune blistering skin disease. Current treatment strategies are limited by their efficacy and/or side effect profile and the need for safer and effective alternatives is undeniable. We aimed to conduct a systematic review focusing on the efficacy and safety of omalizumab in BP patients. Embase, PubMed, Cochrane, and clinicaltrials.gov were searched for English and French articles published from inception to July 1, 2021, using search terms “omalizumab” OR “Xolair” OR “IGE025” OR “olizumab” AND “bullous pemphigoid. ” Screening and data extraction was performed by two raters independently. The primary outcome was complete response (CR), and secondary outcomes were partial response (PR), flare-ups, adverse events/vital status. In total, 22 articles were included, with a total of 56 patients. All patients had a refractory BP with mean disease duration of 13.5 ± 20.2 months (Standard Deviation (SD)) and failed 3.1 ± 1.6 therapies and many remained corticosteroids dependent. Overall, 87.5% of patients responded to treatment (55.4% CR and 32.1% PR), 7.1% discontinued the protocol and only 5.4% were non responders. A third of patients were able to discontinue all other therapies and most others were able to discontinue or taper systemic corticosteroids to <10 mg daily. Flare-ups occurred in 57.7% of patients upon discontinuation of omalizumab and/or steroid tapering, most patients recaptured response thereafter. Omalizumab was well tolerated by most patients. Omalizumab appears to be a promising treatment for BP with a good response rate and safety profile. However, several limitations were identified in current literature, and highlight the need for randomized controlled trials of omalizumab in BP.
Assessment of the relationship between COVID-19 risk perception and vaccine acceptance: a cross-sectional study in Jordan

ABSTRACT Background In the absence of definitive treatment, vaccination against COVID-19 emerged as an effective solution to the spread of the pandemic. This study aimed to investigate the factors impacting the rates of COVID-19 vaccine acceptance in Jordan, in addition to examining the relationship between COVID-19 risk perception and vaccine acceptance among the Jordanian population. Methods This cross-sectional study was conducted among a sample of adults (aged ≥18) residing in Jordan. Data were collected using an online questionnaire disseminated using social media platforms between December 2nd and December 29th, 2020. Results A total of 2,268 (72.3%) participants demonstrated willingness to receive the COVID-19 vaccine. The mean COVID-19 risk perception score among the participants was 4.65 out of 10 (median 5; IQR 3–6). Higher risk perception scores were significantly associated with being female (p = .001), young (p < .001), or a smoker (p = .005). A significant positive correlation was identified between COVID-19 vaccine acceptance and risk perception scores (OR = 1.319, 95%, CI = 1.261–1.380, p < .001). Moreover, male participants (75%, OR = 1.220, 95% CI = 1.007–1.479, p = .043), participants aged 18–24 years (78.1%, OR = 1.635, 95% CI = 1.189–2.246, p = .002), and participants with children aged under 18 years (73.9%, OR = 1.210, 95% CI = 1.010–1.450, p = .039) were more willing than their counterparts to get vaccinated. Conclusion COVID-19 risk perception and certain sociodemographic characteristics (i.e., being male, being young, and having children aged under 18 years) were found to be significantly associated with vaccine acceptance. Policymakers are recommended to develop public educational campaigns to enhance people’s trust in and willingness to take the COVID-19 vaccine.
Reframing communications that encourage individuals to reduce food waste

ABSTRACT The waste of edible food throughout the food chain is recognised as a global issue and academic research focuses on how to encourage reductions in this waste. At the consumer level, governments are investing in communication campaigns that encourage individuals to reduce the amount of edible food discarded in their home-based activities. The specific aims of this paper were to identify causes of food waste and what experts recommend for reducing the problem, to identify gaps between information provided in food waste communication campaigns and the experts recommendations, and finally to empirically identify further gaps between individuals’ knowledge of food waste with a framework of the expert recommendations. In terms of findings, the literature review identified a range of causes and nine relevant expert recommendations for reducing this waste. An evaluation of a number of major consumer-focused communication campaigns available in Australia and New Zealand provided evidence that these campaigns were addressing some of the recommendations from experts. A subsequent qualitative investigation of household members’ knowledge of the issues of food discard showed that individuals’ understandings can be prioritised in terms of the expert recommendations and the communication messages in the campaigns. Further research is identified based on these findings.
Assessing the Effect of Environmental Vibration in Buildings - BS 7385: Part 2 *

A new British Standard on the effect of groundborne vibration on buildings has been developed. Guide values for environmental vibration are given for both transient and continuous vibration at the foundation level of the building. These guide values have been proposed based upon a survey of damage data of UK origin, and a review of both international data and experience. Procedures for both vibration measurement and pre/post exposure building inspections are recommanded to ensure that as far as possible, effects are attributed to the correct cause.
Optimization of spatial sample conflgurations using hybrid genetic algorithm and simulated annealing

The accuracy of results obtained by geostatistical analysis, regarding spatial prediction, depends substantially on determining more e‐cient sampling schemes, with a reduced number of samples. This in the sense that the obtained results are similar to the actual results in the area, thus reducing operational costs. By using simulated data, the present work has laid plans for e‐cient spatial sampling in the prediction of variables with spatial dependence. The simulated annealing and hybrid genetic algorithm (GA) methods of optimization are used, considering the mean of the prediction variance as objective function. In addition, this work allows us to resize a sample conflguration. This has already been applied to an experiment of precision agriculture in the cultivation of soy